NEUROFIBRILLARY TANGLES & AMYLOID PLAQUES ARE DIAGNOSTIC FEATURES OF ALZHEIMER'S DISEASE 
NEUROFIBRILLARY TANGLES  (-NFTs) are intracellular aggregates of hyperphosphorylated tau protein that are most commonly known as a  primary biomarker of 
Alzheimer's disease. Their presence is also found in numerous other diseases known as tauopathies. Little is known about their exact relationship to the different pathologies. Neurofibrillary tangles are formed by hyperphosphorylation of a microtubule-associated protein known as tau, causing it to aggregate, or group, in an insoluble form. (These aggregations of hyperphosphorylated tau protein are also called  PHF, or "paired helical filaments").Precise mechanism of tangle formation is not completely understood, though it is typically recognized that tangles are a primary causative factor in neurodegenerative disease.
AMYLOID PLAQUES -Amyloid plaques are clumps of protein that form between nerve cells in the brain. They are a key feature of Alzheimer's disease.Amyloid precursor protein (APP) breaks down to form beta-amyloid protein.  Beta-amyloid 42 is a form of beta-amyloid that is particularly toxic.  Beta-amyloid misfolds and aggregates into oligomers and polymers, which form plaques. 
Amyloid plaques disrupt cell function. They prevent nutrients and other supplies from moving through cells, which can cause cells to die.
Drugs like lecanemab and donanemab can help reduce amyloid plaques.
These drugs can slow the progress of Alzheimer's-related cognitive decline in some people.
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