γ-Secretase Inhibition (GSI) in MM: this can improve the efficacy of BCMA-targeted therapies (CAR-T, ADC, TCE) in RRMM by increasing BCMA surface expression, reducing soluble BCMA levels, and modulating the tumor microenvironment without impairing T-cell function. This combination strategy appears to mitigate mechanisms of resistance to these therapies and improves overall PFS
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