An excellent review article by @12VRavindran sir. A must read for all the doctors!

🍁Low-dose methotrexate (LD-MTX) is a widely used treatment for various rheumatological and non-rheumatological conditions. 

🍁Despite misconceptions stemming from its high-dose counterpart used in cancer therapy, current evidence supports the safety of LD-MTX. 

🍁It is not associated with liver and lung fibrosis, and major concerns like bone marrow suppression and increased infection risk are rare. 

🍁Hypersensitivity pneumonitis is a rare acute lung toxicity, but LD-MTX does not cause interstitial lung disease and may even be protective against it. 

🍁There is a slight increased risk of skin malignancy, but no association with other cancers. 

🍁LD-MTX is considered an immunomodulator rather than an immunosuppressant, making it safer for long-term use. 

🍁It can cause mild gastrointestinal and hematological side effects, which are manageable. 

🍁LD-MTX is teratogenic, so contraception is advised, but first-trimester exposure may be relatively safe. 

🍁Overall, LD-MTX is a safe and effective treatment for autoimmune diseases, and its safety profile is distinct from high-dose methotrexate.

@IhabFathiSulima #MedTwitter #RheumTwitter #MedX