Following the study (link in thread) below I am adding 4 medicines to my stack.
* this is by no means health advice - please do your research *

Summary of the four new interventions I am adding, along with their purposes, starting doses, and best times to take them:

1. Dapagliflozin (5 mg)

Purpose:
•SGLT-2 inhibitor that lowers blood glucose by promoting glucose excretion via the kidneys.
•Benefits:
•Improves glucose control.
•Supports weight loss by increasing fat oxidation and promoting mild ketosis.
•Provides cardiovascular and renal protection, even in non-diabetic individuals.

Starting Dose:
•5 mg once daily (starting dose).

Best Time to Take:
•Morning with or without food.
•Taking it in the morning aligns with natural glucose fluctuations and ensures effective daytime glucose control.
•Ensure adequate hydration to avoid dehydration due to increased urination.

2. Risedronate (35 mg)

Purpose:
•Bisphosphonate that inhibits osteoclast activity, reducing bone resorption and preserving bone density.
•Benefits:
•Prevents osteoporosis and fractures.
•May have secondary benefits in reducing systemic inflammation and potentially interacting with longevity pathways.

Starting Dose:
•35 mg once weekly (standard dose for osteoporosis prevention).

Best Time to Take:
•First thing in the morning on an empty stomach.
•Take with a full glass of water (at least 250 mL).
•Remain upright (sitting or standing) for at least 30 minutes after taking to avoid esophageal irritation.
•Avoid eating, drinking (other than water), or taking other medications for at least 30 minutes post-dose.

3. Telmisartan (20 mg)

Purpose:
•ARB (Angiotensin II Receptor Blocker) that lowers blood pressure and has additional metabolic benefits.
•Benefits:
•Improves cardiovascular health and protects against hypertension.
•Activates PPARγ, improving insulin sensitivity and potentially aiding metabolic health and fat loss.
•Reduces inflammation and oxidative stress.

Starting Dose:
•20 mg once daily (standard starting dose for most individuals).

Best Time to Take:
•Morning:
•Telmisartan aligns well with the body’s natural blood pressure rhythms, peaking in the morning.
•Can be taken with or without food.

4. Dasatinib (100 mg) + Quercetin (500 mg)

Purpose:
•Senolytic therapy targeting senescent (aging) cells to promote cellular health and reduce inflammation.
•Benefits:
•Improves tissue repair and reduces chronic inflammation by clearing senescent cells.
•Supports longevity by enhancing metabolic flexibility and cellular turnover.

Starting Dose:
•Dasatinib: 100 mg once daily for 3 consecutive days per week (senolytic protocol).
•Quercetin: 500 mg twice daily for the same 3 days as Dasatinib.

Best Time to Take:
•Morning on an empty stomach:
•Maximizes bioavailability for both Dasatinib and Quercetin.
•Pair with a low-calorie or fasting state for optimal senolytic effects.
•If GI discomfort occurs, take with a small, light meal.

Overall notes:
•Hydration: Dapagliflozin increases urination, so ensure adequate fluid intake.
•Bone Monitoring: With Risedronate, ensure adequate calcium (1,000 mg/day) and Vitamin D (2,000–4,000 IU/day) intake to support bone health.
•Scheduling:
•Space out Dapagliflozin, Risedronate, and Telmisartan to avoid interactions or side effects.
•Align senolytic cycles (Dasatinib + Quercetin) with rest days or lower activity periods to monitor for fatigue or other effects.