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Title: Mitochondria is the reason
Review: Mitochondria is the reason there are no prokaryotic mice. If we calculate the actual measured energy per gene in prokaryotes andeukaryotes of similar size, taking into consideration the measured metabolic rates per cell and the known ploidy, then the actual power per gene of both Epulopiscium and Thiomargarita falls in the range of 15,000 to 50,000 times lower than A. proteus. This is in the same order of magnitude as Lane's calculated values, and would be expected to be lower, given that the larger part of the cell volume in these giant prokaryotes is metabolically inert. One might argue that this metabolic inertia is in fact forced upon these giant bacteria by the exorbitant energetic costs of maintaining all those additional genomes.
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