Title: Vinpocetine can cause depression by depleting dopamine and other neurotransmitters
Product review: Vinpocetine inhibits IKK preventing I'B degradation and the following translocation of NF-'B to the cell nucleus. Increases in neuronal levels of DOPAC, a metabolic breakdown product of dopamine, have been shown to occur in striatal isolated nerve endings as a result of exposure to vinpocetine.Such an effect is consistent with the biogenic pharmacology of reserpine, a structural relative of vinpocetine, which depletes catecholamine levels and causes depression as a side effect of the cardiovascular and anti-psychotic effects.[15] However, this effect tends to be reversible upon cessation of Vinpocetine administration, with full remission typically occurring within 3-4 weeks.Anecdotal evidence confirms this dopmaine depletion leading to low energy, difficulty focusing, loss of drive, ambition, etc.I would try gingko or rhodiola for memory or brain enhancement.[...]
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