tokens: CD28+ CD8 ( + ) T cells unable to transcribe the IL-2 gene in response to antigenic stimulation had a block in transactivation of the -150 CD28 response element ( CD28RE ) /AP-1 site of the IL-2 promoter , but did transactivate the composite NFAT/AP-1 and OCT/AP-1 sites , and a consensus AP-1 motif .