tokens: The up-regulation of TRAIL on IFN-beta -stimulated DCs partially contributed to the increased cytotoxicity of DCS : Pretreatment of TRAIL-sensitive tumor cells with caspase-3 inhibitor could significantly increase their resistance to the cytotoxicity of IFN-beta -stimulated DCS : In contrast , NF-kappaB inhibitor could significantly increase the sensitivity of tumor cells to the killing by nonstimulated or LPS-stimulated DCS : Our studies demonstrate that IFN-beta -stimulated DCs are functionally cytotoxic .