tokens: In B6 mice , flow cytometry demonstrated an IL-1-dependent leukocyte infiltration into the synovial compartment and RNase protection assays revealed induction of messenger RNA ( mRNA ) for the chemokines monocyte chemoattractant protein 1 , macrophage inhibitory protein 2 ( MIP-2 ) , RANTES , MIP-1alpha , and MIP-1beta , in vivo and in vitro .