tokens: We addressed the role of hyperglycemia in leukocyte-endothelium interaction under flow conditions by exposing human umbilical vein endothelial cells for 24 h to normal ( 5 mM ) , high concentration of glucose ( 30 mM ) , advanced glycosylation end product-albumin ( 100 microg/ml ) , or hyperglycemic ( 174-316 mg/dl ) sera from patients with diabetes and abnormal hemoglobin A1c ( 8.1+/-1.4 % ) .