tokens: CONCLUSION/INTERPRETATION : These results suggest that high glucose can upregulate intercellular adhesion molecule-1 protein and mRNA expression but not vascular adhesion molecule-1 expression in mesangial cells and promote leukocyte adhesion through up-regulation of intercellular adhesion molecule-1 through osmotic effect , possibly depending on the protein kinase C nuclear factor-kappa B ( PKC - NF-kappa B ) pathway .