Title: Searching for Biophysically Realistic Parameters for Dynamic Neuron Models by Genetic Algorithms from Calcium Imaging Recording,
Abstract: Individual Neurons in the nervous systems exploit various dynamics. To
capture these dynamics for single neurons, we tune the parameters of an
electrophysiological model of nerve cells, to fit experimental data obtained by
calcium imaging. A search for the biophysical parameters of this model is
performed by means of a genetic algorithm, where the model neuron is exposed to
a predefined input current representing overall inputs from other parts of the
nervous system. The algorithm is then constrained for keeping the ion-channel
currents within reasonable ranges, while producing the best fit to a calcium
imaging time series of the AVA interneuron, from the brain of the soil-worm, C.
elegans. Our settings enable us to project a set of biophysical parameters to
the the neuron kinetics observed in neuronal imaging.