Title: Performance Analysis of MEC Approach for Haplotype Assembly,
Abstract: The Minimum Error Correction (MEC) approach is used as a metric for
reconstruction of haplotypes from NGS reads. In this paper, we show that the
MEC may encounter with imprecise reconstructed haplotypes for some NGS devices.
Specifically, using mathematical derivations, we evaluate this approach for the
SOLiD, Illumina, 454, Ion, Pacific BioSciences, Oxford Nanopore, and 10X
Genomics devices. Our results reveal that the MEC yields inexact haplotypes for
the Illumina MiniSeq, 454 GS Junior+, Ion PGM 314, and Oxford Nanopore MK 1
MinION.