Title: Fast-slow asymptotics for a Markov chain model of fast sodium current,
Abstract: We explore the feasibility of using fast-slow asymptotic to eliminate the
computational stiffness of the discrete-state, continuous-time deterministic
Markov chain models of ionic channels underlying cardiac excitability. We focus
on a Markov chain model of the fast sodium current, and investigate its
asymptotic behaviour with respect to small parameters identified in different
ways.