Title: Unveiled electric profiles within hydrogen bonds suggest DNA base pairs with similar bond strengths,
Abstract: Electrical forces are the background of all the interactions occurring in
biochemical systems. From here and by using a combination of ab-initio and
ad-hoc models, we introduce the first description of electric field profiles
with intrabond resolution to support a characterization of single bond forces
attending to its electrical origin. This fundamental issue has eluded a
physical description so far. Our method is applied to describe hydrogen bonds
(HB) in DNA base pairs. Numerical results reveal that base pairs in DNA could
be equivalent considering HB strength contributions, which challenges previous
interpretations of thermodynamic properties of DNA based on the assumption that
Adenine/Thymine pairs are weaker than Guanine/Cytosine pairs due to the sole
difference in the number of HB. Thus, our methodology provides solid
foundations to support the development of extended models intended to go deeper
into the molecular mechanisms of DNA functioning.