Title: Identification of Key Proteins Involved in Axon Guidance Related Disorders: A Systems Biology Approach,
Abstract: Axon guidance is a crucial process for growth of the central and peripheral
nervous systems. In this study, 3 axon guidance related disorders, namely-
Duane Retraction Syndrome (DRS) , Horizontal Gaze Palsy with Progressive
Scoliosis (HGPPS) and Congenital fibrosis of the extraocular muscles type 3
(CFEOM3) were studied using various Systems Biology tools to identify the genes
and proteins involved with them to get a better idea about the underlying
molecular mechanisms including the regulatory mechanisms. Based on the analyses
carried out, 7 significant modules have been identified from the PPI network.
Five pathways/processes have been found to be significantly associated with
DRS, HGPPS and CFEOM3 associated genes. From the PPI network, 3 have been
identified as hub proteins- DRD2, UBC and CUL3.