Title: Phenotype-based and Self-learning Inter-individual Sleep Apnea Screening with a Level IV Monitoring System,
Abstract: Purpose: We propose a phenotype-based artificial intelligence system that can
self-learn and is accurate for screening purposes, and test it on a Level IV
monitoring system. Methods: Based on the physiological knowledge, we
hypothesize that the phenotype information will allow us to find subjects from
a well-annotated database that share similar sleep apnea patterns. Therefore,
for a new-arriving subject, we can establish a prediction model from the
existing database that is adaptive to the subject. We test the proposed
algorithm on a database consisting of 62 subjects with the signals recorded
from a Level IV wearable device measuring the thoracic and abdominal movements
and the SpO2. Results: With the leave-one cross validation, the accuracy of the
proposed algorithm to screen subjects with an apnea-hypopnea index greater or
equal to 15 is 93.6%, the positive likelihood ratio is 6.8, and the negative
likelihood ratio is 0.03. Conclusion: The results confirm the hypothesis and
show that the proposed algorithm has great potential to screen patients with
SAS.