Title: simode: R Package for statistical inference of ordinary differential equations using separable integral-matching,
Abstract: In this paper we describe simode: Separable Integral Matching for Ordinary
Differential Equations. The statistical methodologies applied in the package
focus on several minimization procedures of an integral-matching criterion
function, taking advantage of the mathematical structure of the differential
equations like separability of parameters from equations. Application of
integral based methods to parameter estimation of ordinary differential
equations was shown to yield more accurate and stable results comparing to
derivative based ones. Linear features such as separability were shown to ease
optimization and inference. We demonstrate the functionalities of the package
using various systems of ordinary differential equations.