Title: Mathematical model of immune response to hepatitis B,
Abstract: A new detailed mathematical model for dynamics of immune response to
hepatitis B is proposed, which takes into account contributions from innate and
adaptive immune responses, as well as cytokines. Stability analysis of
different steady states is performed to identify parameter regions where the
model exhibits clearance of infection, maintenance of a chronic infection, or
periodic oscillations. Effects of nucleoside analogues and interferon
treatments are analysed, and the critical drug efficiency is determined.