Title: Neural correlates of episodic memory in the Memento cohort,
Abstract: IntroductionThe free and cued selective reminding test is used to identify
memory deficits in mild cognitive impairment and demented patients. It allows
assessing three processes: encoding, storage, and recollection of verbal
episodic memory.MethodsWe investigated the neural correlates of these three
memory processes in a large cohort study. The Memento cohort enrolled 2323
outpatients presenting either with subjective cognitive decline or mild
cognitive impairment who underwent cognitive, structural MRI and, for a subset,
fluorodeoxyglucose--positron emission tomography evaluations.ResultsEncoding
was associated with a network including parietal and temporal cortices; storage
was mainly associated with entorhinal and parahippocampal regions, bilaterally;
retrieval was associated with a widespread network encompassing frontal
regions.DiscussionThe neural correlates of episodic memory processes can be
assessed in large and standardized cohorts of patients at risk for Alzheimer's
disease. Their relation to pathophysiological markers of Alzheimer's disease
remains to be studied.