context: Though oxygen anion redox processes remarkably boost the specific capacity of LLOs, they trigger some intractable issues, such as voltage/capacity fade, voltage hysteresis, low initial Coulombic efficiency, and inferior rate capability. It has been demonstrated that the voltage hysteresis is caused by the poor kinetics of anionic redox reactions and grows progressively with overoxidation of lattice oxygen anions. Continuous side reactions between overoxidized oxygen anions and organic electrolytes give rise to a thick cathode electrolyte interphase (CEI) film, which deteriorates the interfacial charge-transfer kinetics. Besides, the oxygen anion redox reactions greatly affect the stability of the cationic redox chemistry of these 3d-TM LLOs. Namely, the oxidation of oxygen anions is usually accompanied by irreversible TM migration into neighboring Li 3a vacancies, resulting in structural transformation from the layered to spinel and/or rock-salt phases, which further leads to capacity/voltage fade. Strategies for mitigation of these issues have focused on surface coating, inactive-ion doping, a composition-graded structure, and optimization of chemical composition. In particular, regulating the anionic redox behaviors by tuning the cation arrangement and oxygen stacking sequence has captured great attention recently. Although some intriguing progress has been made, it is a long way towards their real-world implementation in high energy-density LIBs.