Induction of squamous cell carcinoma with 3,4-benzo[a]pyrene in the human bronchus transplanted into nude mice.
By the intraluminal injection of 3,4-benzo[a]pyrene into human bronchial grafts in nude mice, squamous cell carcinoma was induced in one bronchial graft out of 17 benzo[a]pyrene-treated grafts. As benzo[a]pyrene is one of the most common carcinogens in the human environment, this experimental system should serve as an excellent model system for studying the process of carcinogenesis in the human respiratory tract.