A highly sensitive microRNA biosensor based on ruthenium oxide nanoparticle-initiated polymerization of aniline.
Well-defined voltammetric current peaks of polyaniline were observed at biosensors hybridized with ruthenium oxide nanoparticle-tagged microRNAs and incubated in a mixture of aniline/H(2)O(2), which can be used for direct microRNA expression profiling with excellent sensitivity.