Central synaptic neurotransmission: universal self-regulation theory.
A prospective randomized study based on case monitoring and treatment of the patients with chronic tension-type headache was carried out, which revealed the regularities in the effects of basic groups of central neurotropic drugs on clinical manifestations and the EEG data. The patients of control (n=90) and experimental (n=91) groups were followed up for 3 months. The experimental group patients were treated with central neurotropic preparations in addition to the routine medicines having peripheral effects. The control group patients received only the routine preparations. The efficiency was assessed by clinical and EEG criteria. The data obtained were analyzed based on fundamental views of modern experimental neurobiology on the gradual nature of postsynaptic responses and their role in universal process of the central neurotransmission. This analysis led to the views on neurochemical origin of EEG rhythms, which has not been yet defined. A theory is advanced, which is based on clinical experience gained in the process of treatment of various functional CNS disorders in more than 5000 patients. This theory makes it possible to use EEG as an objective criterion of efficiency of neurotropic drugs administered to correct central neurotransmission in the patients with clinical pathological functional disorders of CNS.