[Association research between polymorphism of IFN-gamma and IL-10, environmental risk factors, and susceptibility to esophageal cancer].
To explore the polymorphism of interferon-gamma (IFN-gamma) and interleukin-10 (IL-10) with susceptibility to esophageal cancer (EC), as well as the interaction between the environmental risk factors and the polymorphism of IFN-gamma or IL- 10. To explore the interaction between the polymorphism of IFN-gamma and IL-10. According to the case-control design, 120 EC cases and 122 controls were examined. PCR technology was used to determine the genotypes of IFN-gamma + A874T and IL-10 -A1082G. Indicators of quantitative analysis for interaction between IFN-gamma and IL-10, and parts of environmental factors were calculated by crossover analysis multiplicative mode. Allele frequencies of T of IFN-gamma + A874T was 37.92% in case group higher than 28.7% in control group (chi2 = 4.6414, P = 0.0312). Compared with IFN-gamma + 874AA genotype, OR of IFN-gamma + 874AT genotype was 1.729 (95% CI 1.015-2.947), OR of IFN-gamma + 874TT genotype was 2.923 (95% CI 1.227-5.214) and OR of IFN-gamma + 874AT + TT genotype was 1.821 (95% CI 1.081-3.069). There was synergistic action between IFN-gamma + 874AT + TT and drink index, moldy food and regular diet habit, their S respectively were 1.909, 4.154 and 5.026. The interaction between IFN-gamma + 874AT + TT and IL-10 -1082AG + GG was not increased the risk of EC OR = 2.342 (95% CI 0.975-5.626). The IFN-gamma + 874AT genotype might be a risk factor to EC. T allele gene may be heredity predisposing gene of EC. IFN-gamma + 874 AT + TT genotype as the corresponding reduction of the environmental risk factors can reduce the incidence of esophageal cancer.