CGS 8216, a novel anorectic agent, selectively reduces saccharin solution consumption in the rat.
The pyrazoloquinoline CGS 8216, a high-affinity ligand for benzodiazepine recognition sites, significantly reduced the consumption of a preferred 0.05% sodium saccharin solution in a 30 min two-bottle test. A highly significant effect was detected at 5.0 mg/kg, IP and at higher doses. The consumption of water and 0.6% saline, in two-bottle tests, or of quinine solution and water, in a forced-choice test, was not reliably affected by CGS 8216. The results point to a sensitive and selective intrinsic effect of CGS 8216 on ingestional responses in the rat.