Metal-free enantioselective hydroxyamination of aldehydes with nitrosocarbonyl compounds catalyzed by an axially chiral amine.
The first example of a highly regio- and enantioselective hydroxyamination of aldehydes with in situ generated nitrosocarbonyl compounds from hydroxamic acid derivatives was realized by combined use of TEMPO and BPO as the oxidant in the presence of a binaphthyl-modified amine catalyst.