<SEC-HEADER>0001532063-17-000004.hdr.sgml : 20170214
<ACCEPTANCE-DATETIME>20170214164146
ACCESSION NUMBER:		0001532063-17-000004
CONFORMED SUBMISSION TYPE:	10-K
PUBLIC DOCUMENT COUNT:		103
CONFORMED PERIOD OF REPORT:	20161231
FILED AS OF DATE:		20170214
DATE AS OF CHANGE:		20170214

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Express Scripts Holding Co.
		CENTRAL INDEX KEY:			0001532063
		STANDARD INDUSTRIAL CLASSIFICATION:	RETAIL-DRUG STORES AND PROPRIETARY STORES [5912]
		IRS NUMBER:				452884094
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		10-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-35490
		FILM NUMBER:		17609708

	BUSINESS ADDRESS:	
		STREET 1:		ONE EXPRESS WAY
		CITY:			ST. LOUIS
		STATE:			MO
		ZIP:			63121
		BUSINESS PHONE:		314-996-0900

	MAIL ADDRESS:	
		STREET 1:		ONE EXPRESS WAY
		CITY:			ST. LOUIS
		STATE:			MO
		ZIP:			63121

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Aristotle Holding, Inc.
		DATE OF NAME CHANGE:	20111005
</SEC-HEADER>