Mineralocorticoid Antagonists @BCNephro
Brian Cronin
[{'start': '0.240', 'end': '5.120', 'text': 'There are three mineralocorticoid\xa0\nantagonist available in the US. The'}, {'start': '5.120', 'end': '12.560', 'text': 'first is spironolactone a first generation\xa0\nsteroidal mineralocorticoid antagonist that'}, {'start': '12.560', 'end': '18.000', 'text': 'is not selective for the mineralocorticoid\xa0\nreceptor, that means it can also block other'}, {'start': '18.000', 'end': '24.720', 'text': 'receptors such as progesterone and androgen\xa0\nreceptors. Second is a eplerenone which is a'}, {'start': '24.720', 'end': '31.280', 'text': 'second generation steroidal mineralocorticoid\xa0\nantagonist and this is more selective for the'}, {'start': '31.280', 'end': '37.120', 'text': 'mineralocorticoid receptor it is however less\xa0\npotent than spironolactone and finally the most'}, {'start': '37.120', 'end': '43.280', 'text': 'recent medication is finerenone. This is a\xa0\nnon-steroidal mineralocorticoid antagonist'}, {'start': '43.280', 'end': '49.440', 'text': 'and for this reason it is the most selective of\xa0\nthe three for the mineralocorticoid receptor.'}]