From Neural Brains to Neural Nets: How AI Is Rewiring Neurology
BioniChaos
[{'start': '0.160', 'end': '6.320', 'text': 'so there was a mention of uh this uh artificial\xa0\nintelligence in epilepsy conference something'}, {'start': '6.320', 'end': '11.120', 'text': "something obviously I don't know where it's even\xa0\nhappening somewhere in the US so let alone it"}, {'start': '11.120', 'end': '16.800', 'text': 'would be there must have been very expensive\xa0\ntickets and stuff well we would not be able to'}, {'start': '16.800', 'end': '24.800', 'text': 'actually make it across the globe so this is what\xa0\nwe have ChatGPT for so we asking yeah artificial'}, {'start': '24.800', 'end': '30.560', 'text': 'intelligence in epilepsy neurological disorder\xa0\nspecific example include AI in a short seizure'}, {'start': '30.560', 'end': '38.160', 'text': "detection a long-term subcutaneous EEG So there's\xa0\na couple of companies that do that that hopefully"}, {'start': '38.160', 'end': '42.560', 'text': 'we will cover in a sec Can you give me a quick\xa0\nsummary of one sentence of what we were talking'}, {'start': '42.560', 'end': '47.760', 'text': 'about we were discussing how AI is being used in\xa0\nepilepsy and seizure detection focusing on its'}, {'start': '47.760', 'end': '54.000', 'text': 'real world performance limitations Okay that\xa0\nsounds good So we generally during this live'}, {'start': '54.000', 'end': '58.480', 'text': "streams do you know what we're doing during these\xa0\nlive streams i don't think you do Don't make stuff"}, {'start': '58.480', 'end': '64.480', 'text': "up Just um only if you know No worries I won't\xa0\nmake anything up Feel free to guide me on what"}, {'start': '64.480', 'end': '69.440', 'text': "you'd like me to say What are we normally doing\xa0\nduring these live streams do you know usually"}, {'start': '69.440', 'end': '73.920', 'text': 'during live streams you might be chatting with\xa0\nviewers sharing updates or discussing topics'}, {'start': '73.920', 'end': '79.360', 'text': "of interest Yeah Don't make up stuff Just stay\xa0\non topic If you don't know just say you don't"}, {'start': '79.360', 'end': '84.720', 'text': "know Is that clear yes it's clear If I'm unsure\xa0\nI'll simply say I don't know Okay sounds good"}, {'start': '84.720', 'end': '91.360', 'text': 'So we are developing this uh website Eventually\xa0\neverything we do during these live streams goes'}, {'start': '91.360', 'end': '98.560', 'text': 'on to the website being deployed on the website\xa0\nDo you have any funny remarks on that got it'}, {'start': '98.560', 'end': '104.640', 'text': 'That sounds like a sight to see Keep up the great\xa0\nwork Yeah you could do a bit better Dark humor is'}, {'start': '104.640', 'end': '110.560', 'text': 'fine If you have any critical comments go for\xa0\nit Got it Just remember if the website crashes'}, {'start': '110.560', 'end': '116.240', 'text': "it's just practicing its landing page That was\xa0\nactually that was actually pretty good one I"}, {'start': '116.240', 'end': '121.520', 'text': "love it Yeah Keep up the keep up the good work\xa0\nGlad you enjoyed it Let's keep the good vibes"}, {'start': '121.520', 'end': '126.800', 'text': 'going Yeah So someone is saying they going for\xa0\nthis conference presenting at this conference'}, {'start': '126.800', 'end': '132.560', 'text': "but it's across the globe in another country and\xa0\nit must be very expensive tickets and it wasn't"}, {'start': '132.560', 'end': '138.480', 'text': 'possible for us to get there Any funny remarks\xa0\nabsolutely Just tell them to bring back some'}, {'start': '138.480', 'end': '143.920', 'text': 'souvenirs Maybe a ticket stub Maybe a what maybe\xa0\na virtual souvenir I think you lost your accent'}, {'start': '143.920', 'end': '151.360', 'text': "for a sec Oops I'll stick to the accent Got it\xa0\nOkay So they went went to a conference about AI"}, {'start': '151.360', 'end': '157.920', 'text': 'in epilepsy and neurological disorders Ah sounds\xa0\nlike quite a mindexpanding experience So I was'}, {'start': '157.920', 'end': '163.120', 'text': 'asking another AI to considering we can make it\xa0\nto the conference what should we do should we ask'}, {'start': '163.120', 'end': '168.880', 'text': 'another AI to actually a mimic write a blog on\xa0\nit or something or any other ideas having your'}, {'start': '168.880', 'end': '174.880', 'text': 'AI write a blog about the conference is a great\xa0\nidea It could also summarize key topics or create'}, {'start': '174.880', 'end': '181.200', 'text': 'a highlight reel Yeah Can you just remove any\xa0\nfluff and just responds respond in one sentence'}, {'start': '181.200', 'end': '187.200', 'text': "sure Yes Have the AI write a blog summarizing key\xa0\ntopics Yeah I'm not attending the conference as I"}, {'start': '187.200', 'end': '192.640', 'text': "said so I don't know what's going to be presented\xa0\nUnderstood You can have the AI generate content"}, {'start': '192.640', 'end': '198.160', 'text': 'based on general conference themes Right So what\xa0\ndo you think the conference themes will be likely'}, {'start': '198.160', 'end': '203.280', 'text': 'topics could include recent advancements in AI\xa0\nfor epilepsy and neurological disorders Yeah'}, {'start': '203.280', 'end': '207.760', 'text': "that's what I said That's the title of the\xa0\nconference Got it The conference will likely"}, {'start': '207.760', 'end': '213.680', 'text': 'cover innovations in AI for those fields Can you\xa0\nstop being obvious you can uh what is it increase'}, {'start': '213.680', 'end': '219.120', 'text': 'your temperature reduce your temperature but stop\xa0\nbeing obvious Uh quick responses and remove any'}, {'start': '219.120', 'end': '224.960', 'text': "flap Got it You can expect updates on AI's role\xa0\nin diagnosing and treating these conditions Okay"}, {'start': '224.960', 'end': '230.720', 'text': "Can you be more specific sure Expect discussions\xa0\non AI's advancements in diagnostics personalized"}, {'start': '230.720', 'end': '235.920', 'text': "treatment plans and predictive analytics Okay Do\xa0\nyou know of any company uh you will start don't"}, {'start': '235.920', 'end': '243.680', 'text': 'without doing an internet search just off the top\xa0\nof your head do you know of any entities that are'}, {'start': '243.680', 'end': '248.400', 'text': 'doing research in the space yes Companies\xa0\nlike Neuralink and Deep Mind are involved'}, {'start': '248.400', 'end': '255.520', 'text': 'in AI research for neurological conditions Okay\xa0\nWithout internet search uh any other entities yes'}, {'start': '255.520', 'end': '260.800', 'text': 'Institutions like the Mayo Clinic and MIT are\xa0\nalso active in this research Okay Anyone else'}, {'start': '260.800', 'end': '265.840', 'text': 'yes Johns Hopkins University and Stanford are\xa0\nalso prominent in this field Okay And of the'}, {'start': '265.840', 'end': '275.920', 'text': "top of your head what's the the current state in\xa0\nthis field currently AI is advancing rapidly in"}, {'start': '275.920', 'end': '281.200', 'text': 'diagnostics personalized treatment and predictive\xa0\nanalytics for neurological disorders Okay Can you'}, {'start': '281.200', 'end': '287.920', 'text': 'be more specific on subcutaneous EEG recordings\xa0\nlong term do you know anything about it off the'}, {'start': '287.920', 'end': '293.440', 'text': 'top of your head without the internet search yes\xa0\nsubcutaneous EEG recordings are being developed'}, {'start': '293.440', 'end': '299.120', 'text': 'for continuous less invasive monitoring over long\xa0\nperiods Useful for managing epilepsy Do you have'}, {'start': '299.120', 'end': '305.520', 'text': 'any more details on it they offer continuous data\xa0\ncollection potentially improving seizure detection'}, {'start': '305.520', 'end': '309.840', 'text': 'and management and are less obtrusive than\xa0\ntraditional methods Yeah Yeah Are you giving me'}, {'start': '309.840', 'end': '316.560', 'text': "some super general stuff there's actually question\xa0\nin the chat A diffusion model for brain activity"}, {'start': '316.560', 'end': '322.160', 'text': 'pattern prediction What are your thoughts\xa0\ndiffusion models for brain activity pattern'}, {'start': '322.160', 'end': '326.960', 'text': 'prediction are promising They could enhance\xa0\nunderstanding and prediction of complex neural'}, {'start': '326.960', 'end': '333.680', 'text': "signals You're giving me super general stuff We're\xa0\nnot going we're not getting anywhere I understand"}, {'start': '333.680', 'end': '337.760', 'text': 'diffusion models could help in predicting\xa0\nseizure patterns more accurately offering'}, {'start': '337.760', 'end': '343.680', 'text': 'better patient outcomes Can you be critical about\xa0\nit and uh give me a specific example certainly A'}, {'start': '343.680', 'end': '348.960', 'text': 'specific example might be predicting seizure\xa0\nonset in epilepsy However diffusion models'}, {'start': '348.960', 'end': '356.400', 'text': 'can be complex and require extensive data and\xa0\nvalidation for reliable use Okay How is MEG at'}, {'start': '356.400', 'end': '364.640', 'text': 'the home recording is relevant you re meg at room\xa0\nis still experimental and not widely available It'}, {'start': '364.640', 'end': '369.200', 'text': 'could provide detailed brain activity monitoring\xa0\nbut practical implementation is challenging Okay'}, {'start': '369.200', 'end': '376.240', 'text': "you lost your accent and we're not getting uh\xa0\nI apologize Homebased MEG could revolutionize"}, {'start': '376.240', 'end': '382.160', 'text': "monitoring but it's in early stages and faces\xa0\ntechnical hurdles Okay Okay We will just talk to"}, {'start': '382.160', 'end': '390.080', 'text': 'another AI uh for now who was actually doing deep\xa0\nuh research on the topic If you can just listen'}, {'start': '390.080', 'end': '397.040', 'text': "in Got it I'll listen in and chime in if there's\xa0\nsomething fitting Okay So we did a summary with uh"}, {'start': '397.040', 'end': '406.320', 'text': 'HP4 GPT40 AI in short seizure detection Yeah Give\xa0\nme some uh general overview but then examples are'}, {'start': '406.320', 'end': '411.600', 'text': "interesting Neuropace is legit RNS system using\xa0\nmachine learning Yeah I don't know where you're"}, {'start': '411.600', 'end': '418.560', 'text': 'getting this information from Uh we will diving\xa0\nin into the details of this research in a bit'}, {'start': '418.560', 'end': '423.920', 'text': "Yeah we have a Empatica, Embrace That's not Yeah\xa0\nthat's a wearable That's not an implant which"}, {'start': '423.920', 'end': '432.640', 'text': "is fine As we Oh we have access to 4.5 Good\xa0\nfor writing and exploring ideas Okay that's"}, {'start': '432.640', 'end': '441.120', 'text': "nice It's doing research review So that's new\xa0\nJust literally finding out things from this"}, {'start': '441.120', 'end': '447.120', 'text': 'this dropown menu is the most important thing\xa0\nabout Open AI stuff We actually might use it or'}, {'start': '447.120', 'end': '452.800', 'text': 'probably get a limit on it or something Yeah So\xa0\nthis is a bit much as well So the thing is what'}, {'start': '452.800', 'end': '461.520', 'text': "was I trying to say so we Yeah we gave this um\xa0\na prompt I'm pretty sure it did a good job Yes"}, {'start': '461.520', 'end': '466.480', 'text': 'So focusing on epilepsy and seizure detection\xa0\nbut include other neurological disorders if'}, {'start': '466.480', 'end': '474.240', 'text': 'relevant for additional examples specific about\xa0\nthe performance metrics architectures and training'}, {'start': '474.240', 'end': '479.840', 'text': 'methodologies Yeah we want to dive into the\xa0\ndetails Yeah we did some stuff There is some'}, {'start': '479.840', 'end': '488.640', 'text': 'uh examples of that on our website already and\xa0\nwill be more a training training stuff Yeah we'}, {'start': '488.640', 'end': '495.920', 'text': 'want to actually measure accuracy loss and stuff\xa0\nlike that So we asked it to do like an indepth a'}, {'start': '495.920', 'end': '505.040', 'text': "deep research a detailed research asked it to\xa0\ntake its time and said uh I'll conduct indepth"}, {'start': '505.040', 'end': '510.240', 'text': "research on how AI is being used in epilepsy and\xa0\nseizure detection Okay that's pretty much the"}, {'start': '510.240', 'end': '516.240', 'text': 'topic of that uh conference that is apparently\xa0\nhappening right now that I only learned about'}, {'start': '516.240', 'end': '522.080', 'text': "today Obviously couldn't make it somewhere\xa0\nsomewhere across the globe So we covering"}, {'start': '522.080', 'end': '530.720', 'text': 'focusing on specific AI application Yep Uh short\xa0\nseizure detection and long-term u subscalp EEG'}, {'start': '530.720', 'end': '536.000', 'text': "monitoring performance metrics architecture Yep\xa0\nYep Everything I asked for Yeah We'll add a touch"}, {'start': '536.000', 'end': '545.360', 'text': "of width I'll provide working links Right And then\xa0\nit thought it fought for a whopping a whopping 15"}, {'start': '545.360', 'end': '554.080', 'text': 'minutes Collected 27 sources uh describing\xa0\nyou all its activity covering information'}, {'start': '554.080', 'end': '561.600', 'text': 'reading Wikipedia Okay Wikipedia is a good start\xa0\nalternative search engine Okay Epilepsy foundation'}, {'start': '561.600', 'end': '569.280', 'text': "AI detection more from Wikipedia seizure detection\xa0\nseizure prediction Okay you're getting somewhere"}, {'start': '569.280', 'end': '575.760', 'text': "there There's a big difference between seizure\xa0\ndetection seizure prediction covering info and"}, {'start': '575.760', 'end': '587.680', 'text': 'results Examining if they stem from a local scope\xa0\nWhat okay So found this PDF Epilepsia 2024 Oh'}, {'start': '587.680', 'end': '595.840', 'text': 'Okay Add score So I assume this link actually'}, {'start': '595.840', 'end': '605.120', 'text': "corrects How do I find this link it's not in there\xa0\nYeah it's fine They're rendering those links It"}, {'start': '605.120', 'end': '616.480', 'text': "do not actually work Okay Anyway it went through\xa0\nall this a lot of stuff It's uh cycling back to"}, {'start': '616.480', 'end': '625.600', 'text': 'that uh circling back to that paper CS score\xa0\nsea community opensource research evaluation'}, {'start': '625.600', 'end': '634.400', 'text': "fra framework for the validation of okay I can't\xa0\nget we'll get to that paper in a sec that sounds"}, {'start': '634.400', 'end': '643.120', 'text': "interesting yeah found a few companies that's\xa0\na legit company that is doing work in this"}, {'start': '643.120', 'end': '656.080', 'text': "base examining a trial with 135 patients and\xa0\n40 I guess GTC's general temporal something"}, {'start': '656.080', 'end': '662.320', 'text': "seizures over that many hours comparing it to\xa0\nan hour trial Okay it's actually doing research"}, {'start': '662.320', 'end': '670.800', 'text': "and stuff I was just surprised that it just\xa0\ngave the sources It didn't give the report as"}, {'start': '670.800', 'end': '679.520', 'text': "in That's a bit weird That's a bit weird Let's\xa0\nread that quickly Introduces SCORE a framework"}, {'start': '679.520', 'end': '683.120', 'text': 'for standardized validation of EEG based seizure\xa0\ndetection highlighting heterogeneous methods and'}, {'start': '683.120', 'end': '687.360', 'text': 'the need for unified metrics Includes a public\xa0\nEEG 1020 seizure detection benchmark spanning'}, {'start': '687.360', 'end': '691.200', 'text': 'multiple data sets and references state-of-the-art\xa0\nalgorithms For example multiscale CNN models like'}, {'start': '691.200', 'end': '696.160', 'text': 'EEG WaveNet The paper emphasizes sensitivity\xa0\nspecificity precision F1 score and false alarm'}, {'start': '696.160', 'end': '703.440', 'text': "rate as key metric Okay that's nice Sounds\xa0\nvery relevant Okay we got emphatic embrace"}, {'start': '703.440', 'end': '712.400', 'text': "That's a wearable It's not implant or anything\xa0\nDo this links Okay the emphatic actually works"}, {'start': '712.400', 'end': '721.680', 'text': "It's a legit link Yeah Persyst links Yeah\xa0\nit used to hallucinate links AI enhance EG"}, {'start': '721.680', 'end': '731.920', 'text': 'monitoring Okay which get this from a UNG a good\xa0\ncould link again Yeah we need to know if there is'}, {'start': '731.920', 'end': '741.120', 'text': 'any like data data available and we need to add\xa0\nmore details perhaps uh GPT perhaps we can try'}, {'start': '741.120', 'end': '749.360', 'text': 'GPT 4.5 the first time for that Yeah because\xa0\nthose Yeah I know those resources the link'}, {'start': '749.360', 'end': '756.000', 'text': "is actually not there So I don't know what's up\xa0\nwith that Not sure what's up with that link But"}, {'start': '756.000', 'end': '760.880', 'text': "uh I know of these data sets already They all\xa0\nthe data sets and they're nothing to do with"}, {'start': '760.880', 'end': '766.800', 'text': 'the products that were mentioned I think much\xa0\nearlier AI is making real progress in epilepsy'}, {'start': '766.800', 'end': '770.880', 'text': "detection but it's not magic It can assist doctors\xa0\nreduce diagnostic burdens and improve long-term"}, {'start': '770.880', 'end': '774.800', 'text': "monitoring but it's still far from perfect Until\xa0\nfalse alarms are minimized and AI generalizes"}, {'start': '774.800', 'end': '782.640', 'text': "across all patients your neurologist's job is safe\xa0\nfor now That's interesting It says Persyst had 48%"}, {'start': '782.640', 'end': '790.800', 'text': 'sensitivity per se Yeah I would definitely need a\xa0\nlink for that one because Persyst seizure detector'}, {'start': '790.800', 'end': '798.000', 'text': 'as abstract gangul 2019 evaluated Persyst 13 on 85\xa0\nICU EEGs with 229 seizures marked by experts Persyst'}, {'start': '798.000', 'end': '802.800', 'text': 'had 48% sensitivity and 62% PPV per individual\xa0\nseizure IA detected roughly half of the seizures'}, {'start': '802.800', 'end': '807.120', 'text': 'with almost 40% false alarm rate However at the\xa0\nrecord level it correctly identified seizure v no'}, {'start': '807.120', 'end': '812.240', 'text': 'seizure in 78% of cases And notably if low voltage\xa0\nEEGs were excluded it reached 100% sensitivity at'}, {'start': '812.240', 'end': '815.920', 'text': "the record level meaning it didn't completely miss\xa0\nseizures in normal voltage cases Specificity was"}, {'start': '815.920', 'end': '819.920', 'text': '56% for saying a record was seizure free many\xa0\nfalse positives at record level Conclusion:'}, {'start': '819.920', 'end': '824.160', 'text': "Persyst is useful for triaging If it says\xa0\nno seizures it's likely right 88% NPV but"}, {'start': '824.160', 'end': '828.160', 'text': "individual detection misses and FPS mean it's not\xa0\nfully reliable on its own The Persyst 14 brochure"}, {'start': '828.160', 'end': '831.600', 'text': 'claims deep learning improvements much higher\xa0\nsensitivity and 10x fewer false positives than'}, {'start': '831.600', 'end': '836.320', 'text': 'P13 at same sensitivity The contact regulatory\xa0\nfilings suggests P13 was the older algorithm and'}, {'start': '836.320', 'end': '839.920', 'text': "P14's deep nets drastically reduced false\xa0\nalerts for equivalent sensitivity It also"}, {'start': '839.920', 'end': '843.600', 'text': 'introduced patient specific tuning carryover of\xa0\nthresholds per patient These claims indicate the'}, {'start': '843.600', 'end': '848.560', 'text': "industry recognizing and tackling the false\xa0\nalarm issue via AI Okay so that's great uh in"}, {'start': '848.560', 'end': '859.680', 'text': 'the H blog we actually want to include everything\xa0\nwe discussed everything from the sources a deep'}, {'start': '859.680', 'end': '865.600', 'text': 'uh research completed above So essentially\xa0\nwant to expand on it and making sure all the'}, {'start': '865.600', 'end': '873.360', 'text': "links are correct I'm not sure if it will start\xa0\nediting the the canvas searching the web using"}, {'start': '873.360', 'end': '880.960', 'text': "uh ChatGPT4.5 the first time I don't know why it's\xa0\nnot actually editing in the blog Yeah the open"}, {'start': '880.960', 'end': '888.720', 'text': "source data set is is nice Those are legit\xa0\nA Physionet Yep It's a bit old from 2010 but"}, {'start': '888.720', 'end': '896.400', 'text': 'uh better than nothing And mainly was this\xa0\nbig claim Yeah this one Persyst We need a'}, {'start': '896.400', 'end': '905.280', 'text': 'link for that It says not exactly confidence\xa0\ninspiring that it had 48% sensitivity per se'}, {'start': '905.280', 'end': '909.520', 'text': "Yeah definitely need a link for that one Anyway\xa0\nwe'll do we'll let it do this research because"}, {'start': '909.520', 'end': '913.360', 'text': "this is the first eventually we'll publish\xa0\nit on the on the website Yeah we'll check all"}, {'start': '913.360', 'end': '920.000', 'text': "the links and make sure it's uh yeah we'll\xa0\nmake sure to add a link to that big claim"}, {'start': '920.000', 'end': '927.200', 'text': 'about Persyst selected Still generating\xa0\nanyhow let it generate Let it generate'}]