Inhalable Lung Cancer Therapy Breakthrough | IL-12 mRNA Exosome Treatment Explained
Capsa
[{'start': '0.160', 'end': '2.160', 'text': "Hello, everyone. Today I've got something"}, {'start': '2.160', 'end': '4.360', 'text': 'truly exciting to share with you. Imagine'}, {'start': '4.360', 'end': '5.960', 'text': 'a world where fighting lung cancer could'}, {'start': '5.960', 'end': '7.760', 'text': 'be as simple as breathing in a mist.'}, {'start': '8.160', 'end': '10.320', 'text': 'Sounds futuristic, right?But thanks to'}, {'start': '10.320', 'end': '11.880', 'text': 'groundbreaking research at Columbia'}, {'start': '11.880', 'end': '14.480', 'text': 'Engineering, this is becoming a reality.'}, {'start': '14.800', 'end': '16.560', 'text': 'Lung cancer remains one of the leading'}, {'start': '16.560', 'end': '18.720', 'text': 'causes of cancer deaths worldwide.'}, {'start': '19.120', 'end': '21.000', 'text': 'Traditional treatments like chemotherapy'}, {'start': '21.000', 'end': '23.120', 'text': 'and radiation can be grueling and often'}, {'start': '23.120', 'end': '25.600', 'text': 'come with severe side effects. But now,'}, {'start': '25.760', 'end': '27.920', 'text': 'researchers are exploring a game-changing'}, {'start': '27.920', 'end': '30.240', 'text': 'approach inhalable therapy. Yes, you'}, {'start': '30.240', 'end': '32.160', 'text': 'heard that right. Instead of systemic'}, {'start': '32.160', 'end': '34.000', 'text': 'injections, patients could soon be'}, {'start': '34.000', 'end': '36.280', 'text': 'inhaling their treatment. So what makes'}, {'start': '36.280', 'end': '38.480', 'text': 'this inhalable therapy so revolutionary?'}, {'start': '38.800', 'end': '41.120', 'text': "Let's dive in. The magic ingredient here"}, {'start': '41.120', 'end': '43.360', 'text': 'is a group of proteins called cytokines.'}, {'start': '43.680', 'end': '46.560', 'text': 'Among them is interleukin-12, or IL-12,'}, {'start': '46.880', 'end': '48.800', 'text': 'renowned for its powerful tumor-fighting'}, {'start': '48.800', 'end': '51.760', 'text': 'abilities. The catch?When IL-12 is'}, {'start': '51.760', 'end': '53.520', 'text': 'injected into the bloodstream, it can'}, {'start': '53.520', 'end': '55.600', 'text': 'cause serious side effects, limiting its'}, {'start': '55.600', 'end': '57.600', 'text': 'use in clinical settings. The challenge'}, {'start': '57.600', 'end': '59.720', 'text': "has always been how to deliver IL-12's"}, {'start': '59.720', 'end': '61.600', 'text': 'benefits without harming healthy tissue.'}, {'start': '61.920', 'end': '63.600', 'text': "Here's where the innovation comes in."}, {'start': '63.840', 'end': '65.280', 'text': 'Scientists have discovered a way to'}, {'start': '65.280', 'end': '67.440', 'text': 'harness the power of IL-12 through a'}, {'start': '67.440', 'end': '69.680', 'text': "brilliant delivery method. They're using"}, {'start': '69.680', 'end': '71.760', 'text': 'tiny, naturally occurring particles'}, {'start': '71.760', 'end': '73.840', 'text': 'called exosomes. Think of them as'}, {'start': '73.840', 'end': '76.720', 'text': 'microscopic mail carriers. These exosomes'}, {'start': '76.720', 'end': '79.520', 'text': 'are loaded with IL-12 mRNA and delivered'}, {'start': '79.520', 'end': '81.520', 'text': 'straight to the lungs via inhalation.'}, {'start': '81.760', 'end': '84.400', 'text': 'This local delivery is key. By targeting'}, {'start': '84.400', 'end': '86.240', 'text': 'the lungs directly, the therapy acts'}, {'start': '86.240', 'end': '88.640', 'text': 'precisely at the tumor site, sparing the'}, {'start': '88.640', 'end': '90.720', 'text': 'rest of the body from harmful exposure.'}, {'start': '91.120', 'end': '93.680', 'text': 'In preclinical trials, inhaled exosomes'}, {'start': '93.680', 'end': '95.600', 'text': 'efficiently reached lung tissue and'}, {'start': '95.600', 'end': '98.480', 'text': 'released IL-12 mRNA. The results'}, {'start': '98.480', 'end': '100.560', 'text': 'were extraordinary. Not only did they'}, {'start': '100.560', 'end': '102.640', 'text': 'suppress tumor growth, but they also'}, {'start': '102.640', 'end': '104.480', 'text': 'stimulated the immune system to fight'}, {'start': '104.480', 'end': '107.320', 'text': 'back, potentially even systemically. The'}, {'start': '107.320', 'end': '109.280', 'text': 'researchers are now collaborating with'}, {'start': '109.280', 'end': '111.520', 'text': "oncologists at Columbia's Medical Center."}, {'start': '111.760', 'end': '113.680', 'text': 'To move this promising therapy into'}, {'start': '113.680', 'end': '116.080', 'text': 'clinical trials, the vision is clear,'}, {'start': '116.080', 'end': '118.400', 'text': 'personalized, inhalable treatments that'}, {'start': '118.400', 'end': '121.000', 'text': 'target lung cancer directly, safely, and'}, {'start': '121.000', 'end': '123.600', 'text': 'effectively. This inhalable IL-12'}, {'start': '123.600', 'end': '125.840', 'text': 'therapy represents a major leap in cancer'}, {'start': '125.840', 'end': '128.400', 'text': 'treatment, combining precision, safety,'}, {'start': '128.480', 'end': '131.000', 'text': 'and effectiveness. If successful in human'}, {'start': '131.000', 'end': '132.840', 'text': 'trials, it could revolutionize the way we'}, {'start': '132.840', 'end': '135.040', 'text': 'treat lung cancer and potentially other'}, {'start': '135.040', 'end': '137.440', 'text': "pulmonary diseases. It's a future filled"}, {'start': '137.440', 'end': '140.080', 'text': 'with hope and new possibilities. So stay'}, {'start': '140.080', 'end': '141.920', 'text': 'tuned and keep your lungs healthy,'}, {'start': '142.080', 'end': '143.480', 'text': 'because the next big breakthrough in'}, {'start': '143.480', 'end': '145.120', 'text': 'cancer treatment could be just a breath'}, {'start': '145.120', 'end': '147.640', 'text': "away. Thanks for watching. Don't forget"}, {'start': '147.640', 'end': '149.680', 'text': 'to like, share, and subscribe for more'}, {'start': '149.680', 'end': '151.760', 'text': 'updates on the latest in medical science.'}, {'start': '152.080', 'end': '154.760', 'text': 'Until next time, breathe easy and take'}, {'start': '154.760', 'end': '155.360', 'text': 'care.'}]