AAC was significantly superior to IB for pain relief at @ minutes and at one , two , three , and four hours postdose ( p < @ ) ; pain intensity difference from one hour through three hours ( p < @ ) ; headache response at two hours ( p = @ ) ; functional disability reduced to little or none at three hours ( p = @ ) ; freedom from phonophobia at three hours ( p = @ ) and photophobia at @ minutes postdose ( p = @ ) ; and use of rescue medication ( p = @ ) .