We conducted a randomized , double-blind , placebo-controlled , dose-ranging , phase @ study to evaluate ISIS @ in untreated patients with fasting triglyceride levels between @ mg per deciliter ( @ mmol per liter ) and @ mg per deciliter ( @ mmol per liter ) ( ISIS @ monotherapy cohort ) , as well as in patients receiving stable fibrate therapy who had fasting triglyceride levels between @ mg per deciliter ( @ mmol per liter ) and @ mg per deciliter ( ISIS @-fibrate cohort ) .