Eligible patients were aged @ years or older , had a history of COPD , a smoking history of @ or more pack-years , a ratio of forced expiratory volume in @ s ( FEV ( @ ) ) to forced vital capacity of @ or less after bronchodilators ( and an FEV ( @ ) of @ % or less of predicted ) , and a documented history of one or more moderate or severe disease exacerbations in the year before screening .