There were no significant differences in the TD-MPI ( HS vs. mannitol : @ vs. @ -LSB- baseline -RSB- , @ vs. @ -LSB- @ min -RSB- , @ vs. @ -LSB- @ min -RSB- , @ vs. @ -LSB- @ min -RSB- , @ vs. @ -LSB- @ min -RSB- ) , E/A ratio , IVCT , and E/E ' either within or between the @ groups at any time point .