Comorbidities are significantly associated with the primary composite of SOLVD time to death or heart failure hospitalization ( SOLVD prevention : HR @ , CI : @-@ @ , P < @ ; SOLVD treatment : HR @ , CI : @-@ @ , P < @ for more than four comorbidities vs. no comorbidities ) , and to death , heart failure hospitalization , and cardiovascular death where the effect of the number of coexisting comorbidities was additive .