The purpose of this study was to assess the efficacy and safety of FOLFOX@ , comprising infusional @-fluorouracil ( @-FU ) / leucovorin ( LV ) and oxaliplatin , with cetuximab compared with UFOX , comprising UFT , an oral prodrug of @-FU , LV , and oxaliplatin , with cetuximab as first-line treatment for mCRC .