Adherence to regular tablets ( median tablets consumed per participant per day of maximum @ ; @ -LSB- IQR @-@ -RSB- in the regular group , @ -LSB- @-@ -RSB- in the as-needed group , and @ -LSB- @-@ -RSB- in the placebo group ) , and number of participants reporting adverse events ( @ -LSB- @ % -RSB- in the regular group , @ -LSB- @ % -RSB- in the as-needed group , and @ -LSB- @ % -RSB- in the placebo group ) were similar between groups .