Mean change from baseline in parameters of glucose homeostasis ( fasting plasma glucose -LSB- FPG -RSB- , glycated hemoglobin -LSB- HbA@c -RSB- , insulin , quantitative insulin-sensitivity check index -LSB- QUICKI -RSB- and homeostasis model of assessment-insulin resistance -LSB- HOMA-IR -RSB- ) and plasma lipid profile were assessed at @ months ( CAPITAIN ) and @ months ( PREVAIL-US ) after initiating treatment .