Of all-grade adverse events that occurred in @ % or more of patients , paraesthesia ( @ -LSB- @ % -RSB- events in @ patients in the FOLFOX group vs three -LSB- @ % -RSB- in @ patients in the cisplatin-fluorouracil group , p < @ ) , sensory neuropathy ( @ -LSB- @ % -RSB- vs one -LSB- @ % -RSB- , p < @ ) , increases in aspartate aminotransferase concentrations ( @ -LSB- @ % -RSB- vs two -LSB- @ % -RSB- , p = @ ) , and increases in alanine aminotransferase concentrations ( @ -LSB- @ % -RSB- vs two -LSB- @ % -RSB- , p = @ ) were more common in the FOLFOX group , whereas serum creatinine increases ( four -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- , p = @ ) , mucositis ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- , p = @ ) , and alopecia ( two -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- , p = @ ) were more common in the fluorouracil and cisplatin group .