A decision tree was developed based on the Clinical Protocol and Therapeutic Guidelines for Ulcerative Colitis , published by the Ministry of Health in the lobby SAS/MS n @ of November @ th , @ and on the algorithms published by the Associao Brasileira de Colite Ulcerativa e Doena de Crohn , aiming to get the cost-effectiveness of mesalazine once daily in granules compared with mesalazine twice daily in tablets .