In GNB@ TT subjects , FDC I/H improved the CS ( FDC I/H = @ @ ; placebo = -@ @ , p = @ ) , QoL ( FDC I/H = @ @ ; placebo = @ @ , p = @ ) , and event-free survival ( hazard ratio : @ , p = @ ) , but not in subjects with the C allele ( for CS , FDC I/H = -@ @ ; placebo = -@ @ , p = @ ; for QoL , FDC I/H = @ @ ; placebo = @ @ , p = @ ; and for event-free survival , p = @ ) .