Analysis of variance for repeated measures showed a significant effect of study treatment in reducing prothrombin fragment @-@ ( p = @ ; interaction with time sample , p = @ ) and plasmin-antiplasmin complex ( p < @ ; interaction with time sample , p < @ ) values but not interleukin @ ( p = @ ; interaction with time sample , p = @ ) and platelet factor @ ( p = @ ; interaction with time sample , p = @ ) .