Increases in IgG binding to insulin , saliva IgA binding to insulin , or CD@ + T-cell proliferative responses to insulin were observed in @ of @ ( @ % -LSB- @ % CI , @ % -@ % -RSB- ) placebo-treated children and in @ of @ ( @ % -LSB- @ % CI , @ % -@ % -RSB- ) children treated with @ mg of insulin , @ of @ ( @ % -LSB- @ % CI , @ % -@ % -RSB- ) treated with @ mg , @ of @ ( @ % -LSB- @ % CI , @ % -@ % -RSB- ) treated with @ mg , and @ of @ ( @ % -LSB- @ % CI , @ % -@ % -RSB- ) treated with @ mg ( P = @ ) .