At week @ , the estimated least squares mean trough FEV@ difference between the groups was -@ L ( least squares mean with indacaterol -LSB- n = @ -RSB- @ L -LSB- SE @ -RSB- vs tiotropium -LSB- n = @ -RSB- @ L -LSB- @ -RSB- ; one-sided @ % CI lower limit -@ L ; p < @ ) .