Ninety patients ( mean age : @ years ) with BPD and currently in an acute manic state were randomly assigned to one of three study conditions : oral loading ( @ mg/kg oral single-dose SV on the first day , then @-@ mg/kg SV daily , divided dose ) , intravenous loading ( @ mg/kg SV intravenous injection on the first day , then @-@ mg/kg orally , divided dose ) , or oral maintenance administration ( @-@ mg/kg SV daily from the beginning ) over the first @ days of treatment .