Dapagliflozin significantly lowered both the fasting and @-hour plasma glucose concentrations and the incremental area under the plasma glucose concentration curve ( G@-@ ) during OGTT by -@ @ mg/dL , -@ @ mg/dL , and -@ @ mg/dL min , respectively , compared to -@ @ , -@ @ , and -@ @ reductions in placebo-treated subjects ( both P < @ ) .