There was no statistically significant improvement in risk factor control between the fixed dose combination and usual care groups over @ months : the difference in systolic blood pressure was -@ mm Hg ( -@ v -@ , @ % confidence interval -@ to @ , P = @ ) , in diastolic blood pressure -@ mm Hg ( -@ v -@ , -@ to @ , P = @ ) and in low density lipoprotein cholesterol -@ mmol/L ( -@ v -@ , -@ to @ , P = @ ) .