In this double-blind , placebo-controlled trial , we randomly assigned @ patients , @ to @ years of age , with ADPKD ( estimated glomerular filtration rate -LSB- GFR -RSB- , @ to @ ml per minute per @ m ( @ ) of body-surface area ) to receive an ACE inhibitor ( lisinopril ) and placebo or lisinopril and an ARB ( telmisartan ) , with the doses adjusted to achieve a blood pressure of @/@ to @/@ mm Hg .