In comparison to saline administration , tetrastarch administration resulted in significantly decreased R ( P = @ ) in healthy dogs , as well as significantly increased activated partial thromboplastin time ( P @ ) , CL@ % ( P @ ) , and K ( P < @ ) and significantly decreased platelet count ( P = @ ) , ( P @ ) , MA ( P < @ ) , and von Willebrand factor antigen ( P < @ ) and collagen binding activity ( P @ ) in both healthy dogs and dogs with systemic inflammation .