To determine the effects of the herbal fixed-dose combination PRO @/@ ( extracts from saw palmetto fruits and stinging nettle roots ) on nocturnal voiding frequency , as measured by question @ of the IPSS questionnaire , in patients with moderate-to-severe LUTS/BPH after @ weeks of treatment compared to placebo , to the - blocker tamsulosin , or to the @-reductase inhibitor finasteride .