At week @ , the fixed-dose combination @ and @ mg/day group had significantly greater reductions in diastolic blood pressure from baseline than both nebivolol @ mg/day ( least-squares mean difference -@ mm Hg , @ % CI -@ to -@ ; p = @ ) and valsartan @ mg/day ( -@ mm Hg , -@ to -@ ; p < @ ) ; all other comparisons were also significant , favouring the fixed-dose combinations ( all p < @ ) .