In this prospective , randomised , clinical trial , patients aged @ months to @ yr undergoing craniosynostosis and scoliosis surgery received fibrinogen concentrate ( @ mg kg ( -@ ) ) at two predefined intraoperative fibrinogen concentrations -LSB- ROTEM ( ) FIBTEM maximum clot firmness ( MCF ) of < @ mm ( conventional ) or < @ mm ( early substitution ) -RSB- .