One hundred seventy-three patients ( @ eyes involved ) who were diagnosed as recurrent HSK definitely , including stromal keratitis and corneal endotheliitis , were divided into three groups randomly : negative control ( placebo ) group was topically administered with @ % GCV ophthalmic gel , @ times per day and @ % fluorometholone eye drops , @ times per day until resolution of HSK ; positive control acyclovir ( ACV ) group was topically adopted the same ophthalmic gel and eye drops and additionally received oral ACV @ mg @ times a day for @ weeks and followed by @ mg @ times per day for @ months ; test GCV group was topically adopted the same treatment as negative control group and additionally received oral GCV @ mg @ times per day for @ weeks .