Antiretroviral therapy ( ART ) - naive adults with estimated glomerular filtration rate @ mL/min were randomized @:@ to receive the darunavir/cobicistat/emtricitabine / tenofovir alafenamide ( D/C/F / TAF ) STR ( TAF : N = @ ) or darunavir + cobicistat + emtricitabine/tenofovir disoproxil fumarate ( TDF : N = @ ) once daily with matched placebos for @ weeks .