The following correlation analyses were performed : ( @ ) response evaluation criteria in solid tumors-defined tumor response with serum soluble protein levels via two distinct multiplex ( n < @,@ ) platforms ; ( @ ) response and time-to-event outcomes with germ line SNPs in vascular endothelial growth factor ( VEGF ) - A and VEGF receptor ( VEGFR ) @ genes ; and ( @ ) response and time-to-event outcomes with tumor immunohistochemistry status for hypoxia-inducible factor @-alpha ( HIF-@ ) and carbonic anhydrase-IX or tumor Von Hippel-Lindau ( VHL ) gene inactivation status .