Compared to placebo patients with mixed episodes , asenapine treatment provided significant improvements ( p < @ ) in Bodily Pain ( asenapine = @ , placebo = @ ) , Social Functioning ( asenapine = @ , placebo = @ ) and Mental Health ( asenapine = @ , placebo = @ ) by Week @ ; by comparison , olanzapine treatment did not lead to significant improvements in any domain of HRQoL compared to placebo .