However , riociguat @ mg significantly increased stroke volume ( +@ mL -LSB- @ % CI , @-@ -RSB- ; P = @ ) and decreased systolic BP ( -@ mm Hg -LSB- @ % CI , -@ to -@ -RSB- ; P = @ ) and right ventricular end-diastolic area ( -@ cm@ -LSB- @ % CI , -@ to -@ -RSB- ; P = @ ) , without significantly changing heart rate , PAWP , transpulmonary pressure gradient , or pulmonary vascular resistance .