Compared with patients on E/C/F / TDF , patients on E/C/F / TAF had smaller reductions in estimated creatinine clearance ( -@ vs. -@ mL/min , P = @ ) , significantly less renal tubular proteinuria , and smaller changes in bone mineral density for hip ( -@ % vs. -@ % , P < @ ) and spine ( -@ % vs. -@ % , P < @ ) .