Fingolimod @ mg caused more of the following adverse events versus placebo : lymphopenia ( @ -LSB- @ % -RSB- patients vs @ patients ) , increased alanine aminotransferase ( @ -LSB- @ % -RSB- vs six -LSB- @ % -RSB- ) , herpes zoster infection ( nine -LSB- @ % -RSB- vs three -LSB- @ % -RSB- ) , hypertension ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) , first-dose bradycardia ( five -LSB- @ % -RSB- vs one -LSB- < @ % -RSB- ) , and first-degree atrioventricular block ( @ -LSB- @ % -RSB- vs seven -LSB- @ % -RSB- ) .