Compared to the control group , the availability of interactive sections significantly increased patient empowerment ( midterm assessment : mean difference = +@ , P = @ , d = @ ; final assessment : mean difference = +@ , P = @ , d = @ ) and reduced medication misuse ( midterm assessment : mean difference = -@ , P = @ , d = @ ; final assessment : mean difference = -@ , P = @ , d = -@ ) in the intervention group .