High-order gene-gene interaction analysis , using classification and regression tree ( CART ) and multifactor dimensionality reduction ( MDR ) revealed that AT@ A@C and NFKB@-@ ATTG ins/del polymorphisms jointly increased the risk of LVD to great extent ( p-value = @ ; OR = @ ) and best four-factor interaction model consisted of AT@ A@C , MMP@ A-@G , MMP@ R@Q and NFKB@-@ ATTG ins/del polymorphisms with testing accuracy of @ and cross validation consistency ( CVC ) = @/@ ( permutation p < @ ) showed increased risk for LVD respectively .