Change scores for COT ( P < @ ) , PWT ( P < @ ) , @-minute walk distance ( P = @ ) , daily average cadence ( P = @ ) , time to minimum calf muscle StO@ during exercise ( P = @ ) , large-artery elasticity index ( LAEI ) ( P = @ ) , and high-sensitivity C-reactive protein ( hsCRP ) ( P = @ ) were significantly different among the @ groups .