A total of @ patients aged @ years to @ years ( World Health Organization performance status ( WHO PS ) @ ) with untreated , resectable advanced squamous cell carcinoma of the larynx ( tumor classification of T@-T@ ) or hypopharynx ( tumor classification of T@-T@-T@ ) with regional lymph nodes in the neck classified as N@ to N@ with no metastases were randomized in this prospective phase @ trial into either the sequential arm ( control ) or the alternating arm ( experimental ) .