Patients given E/C/F / tenofovir alafenamide had significantly smaller mean serum creatinine increases than those given E/C/F / tenofovir disoproxil fumarate ( @ vs @ mg/dL ; p < @ ) , significantly less proteinuria ( median % change -@ vs @ ; p < @ ) , and a significantly smaller decrease in bone mineral density at spine ( mean % change -@ vs -@ ; p < @ ) and hip ( -@ vs -@ ; p < @ ) at @ weeks .