Mean improvements in papilledema grade ( acetazolamide : -@ , from @ to @ ; placebo : -@ , from @ to @ ; treatment effect , -@ ; @ % CI , -@ to -@ ; P < @ ) and vision-related quality of life as measured by the National Eye Institute VFQ-@ ( acetazolamide : @ , from @ to @ ; placebo : @ , from @ to @ ; treatment effect , @ ; @ % CI , @ to @ ; P = @ ) and its @-item neuro-ophthalmic supplement ( acetazolamide : @ , from @ to @ ; placebo : @ , from @ to @ ; treatment effect , @ ; @ % CI , @ to @ ; P < @ ) were also observed with acetazolamide .