Ticagrelor , compared with clopidogrel , reduced the composite of cardiovascular death , myocardial infarction , and stroke in patients with extensive CAD ( @ % vs @ % , hazard ratio -LSB- HR -RSB- @ -LSB- @-@ @ -RSB- ) similar to its reduction in those without extensive CAD ( @ % vs @ % , HR @ -LSB- @-@ @ -RSB- , Pinteraction = @ ) .