Hindlimb unloading for @ days resulted in @ % decrease in total bone mineral content ( BMC ) , @ % decrease in trabecular BMD and trabecular microarchitecture and connectivity were significantly deteriorated in the proximal tibia metaphysis in HU group , while rats with ES at DRG showed significant reduced bone loss that there was @ % increase in total BMC , @ % decrease in trabecular BMD , and significant improvement in trabecular microarchitecture .