The magnitude and timing of peak plasma concentrations of ceftaroline ( active metabolite ) , ceftaroline fosamil ( prodrug ) , and ceftaroline M-@ ( inactive metabolite ) varied according to the ceftaroline fosamil dosing schedule ( q@h or q@h ) and infusion duration ( @ minutes or @ minutes ) , but overall plasma ceftaroline exposures within the respective dosing intervals were broadly similar across cohorts .