Compared with placebo , teriflunomide @ mg reduced the risk of sustained accumulation of disability ( hazard ratio -LSB- HR -RSB- @ -LSB- @ % CI @-@ @ -RSB- ; log-rank p = @ ) ; however , teriflunomide @ mg had no effect on sustained accumulation of disability ( HR @ -LSB- @-@ @ -RSB- ; log-rank p = @ ) .