Respiratory disorders , particularly worsening of COPD , were the most common adverse events ( COPD : indacaterol , @ -LSB- @ % -RSB- of @ patients and tiotropium , @ -LSB- @ % -RSB- of @ patients ) and serious adverse events ( COPD : indacaterol , @ -LSB- @ % -RSB- of @ patients and tiotropium , @ -LSB- @ % -RSB- of @ patients ) .