Response rates were significantly higher with @ mg of naloxegol than with placebo ( intention-to-treat population : study @ , @ % vs. @ % , P = @ ; study @ , @ % vs. @ % , P = @ ; patients with an inadequate response to laxatives : study @ , @ % vs. @ % , P = @ ; study @ , @ % vs. @ % , P = @ ) ; in study @ , response rates were also higher in the group treated with @ mg of naloxegol ( intention-to-treat population , @ % vs. @ % , P = @ ; patients with an inadequate response to laxatives , @ % vs. @ % , P = @ ) .