IV tobramycin was associated with a greater urinary protein leak -LSB- mean difference between treatments @ mg/@hr ( @ to @ ) , p = @ -RSB- and higher urinary levels of markers of acute renal tubular injury : N-acetylglucosaminidase -LSB- @ IU/mmol ( @ to @ ) , p = @ -RSB- , alanine aminopeptidase -LSB- @ IU/mmol ( @ to @ ) , p = @ -RSB- , and @-microglobulin -LSB- @ g/mmol ( @ to @ ) , p = @ -RSB- than TNS .