Patients were treated in a randomized , open-labeled , parallel group clinical trial with either a combination of salmeterol xinafoate/fluticasone propionate ( SF ; Seretide , GlaxoSmithKline ) Diskus ( @/@ g twice daily ) or ipratropium bromide/salbutamol ( IS ; Combivent , Boehringer Ingelheim ) MDI ( @ g/@ g quartic daily ) for @ weeks .