Estimated hourly mean interstitial glucose values based on linear mixed models showed an increase of @ -LSB- SE @ -RSB- mmol/L per hour from @ -LSB- @ -RSB- in patients without KDM and followed a quadratic curve from @ -LSB- @ -RSB- mmol/L at midnight to @ -LSB- @ -RSB- mmol/L at @:@ h in patients with KDM during control periods .