The most common drug-related adverse events of any grade in the @ mg/kg and @ mg/kg groups were fatigue ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) , pruritus ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) , and rash ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) .