The most common grade @ and @ adverse events were hepatotoxicity ( @ -LSB- @ % -RSB- ) , hypertension ( @ -LSB- @ % -RSB- ) , cardiac disorders ( @ -LSB- @ % -RSB- ) , osteoporosis ( @ -LSB- @ % -RSB- ) , hypokalaemia ( @ -LSB- @ % -RSB- ) , and fluid retention or oedema ( @ -LSB- @ % -RSB- ) .