However , following the mixed meal , plasma glucose area under the response curve increased from @ to @ mmol/l , p = @ , as a consequence of both increased insulin resistance -LSB- HOMA-IR : @ ( @ , @ ) vs. @ ( @ , @ ) , p = @ -RSB- and a reduced acute insulin response to glucose -LSB- @ ( @ , @ ) vs. @ ( @ , @ ) pmol/mmol , p = @ -RSB- .