The following significant changes were observed during the course of the study : ( @ ) physical symptom score , hot flash score , and ( @ ) Athens Insomnia Scale score decreased in the high-dose group after @ weeks of treatment ; ( @ ) Hospital Anxiety and Depression Scale Anxiety score and ( @ ) systolic and diastolic blood pressure decreased in the low-dose and high-dose groups after @ weeks ; and , ( @ ) lastly , muscle mass increased in the low-dose and high-dose groups after @ weeks of treatment .