PEARLS , a large scale trial of antiretroviral therapy ( ART ) for HIV ( n = @,@ , @ countries , @ continents ) , found that a once-daily protease inhibitor ( PI ) based regimen ( ATV+DDI+FTC ) , but not a once-daily non-nucleoside reverse transcriptase inhibitor/nucleoside reverse transcriptase inhibitor ( NNRTI/NRTI ) regimen ( EFV+FTC / TDF ) , had inferior efficacy compared to a standard of care twice-daily NNRTI/NRTI regimen ( EFV +@ TC/ZDV ) .