Prospectively , lower baseline HDL-C and HDL-C/apoA-I levels predicted greater uptake ( per @-SD lower : hazard ratio -LSB- HR -RSB- @ -LSB- CI @-@ @ -RSB- , P < @ ; and HR @ -LSB- CI @-@ @ -RSB- , P < @ , respectively ) and earlier uptake ( median @ and @ months , respectively , for quartile @ vs. quartile @ ; both P < @ ) of OHAs and insulin , with no difference in HbA@c thresholds for initiation ( P = @ and P = @ ) .