The most common serious adverse events were COPD exacerbation resulting in admission to hospital ( eight patients -LSB- @ % -RSB- taking placebo , six -LSB- @ % -RSB- taking losmapimod @ mg , two -LSB- @ % -RSB- taking losmapimod @ mg , and three -LSB- @ % -RSB- taking losmapimod @ mg ) and pneumonia ( four -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) .