Rates of edema ( @ % and @ % for Asia and other regions , respectively ) , myalgia ( @ % , @ % ) , nail disorder ( @ % , @ % ) , febrile neutropenia ( @ % , @ % ) , upper respiratory tract infection ( @ % , @ % ) , decreased appetite ( @ % , @ % ) , and rash ( @ % , @ % ) were at least twice as high in Asia as in other regions .