Compared with ticagrelor alone , the geometric least squares mean ( LSM ) ratio ( @ % confidence interval -LSB- CI -RSB- ) for the ticagrelor area under the plasma concentration-time curve from time zero to infinity ( AUC ( ) ) was @ ( @-@ @ ) , and the maximum plasma concentration ( C ( max ) ) was @ ( @-@ @ ) , in the presence of cyclosporine .