In a substudy of a randomised , double-blind , phase @b study ( ACT-RAY ) of biologic-nave patients with RA who were methotrexate ( MTX ) - inadequate responders , @ patients were randomised to continue MTX or receive placebo ( PBO ) , both in combination with TCZ @ mg/kg every @ weeks , with optional additional disease-modifying antirheumatic drugs at week @ if Disease Activity Score of @ joints < @ .