Mean highest placebo-matched change from baseline in QTc was -@ -LSB- @ % confidence interval ( CI ) -@ , -@ -RSB- ms. At supratherapeutic axitinib exposures achieved with potent cytochrome P@ @A@/@ inhibition by ketoconazole , the model predicted mean QTc change of @ ( @ % CI @-@ @ ) ms. The slope population mean estimate was -@ ( @ % CI -@ , @ ) msmL/g for ketoconazole alone and @ ( @-@ @ ) msmL/ng for axitinib in the presence of ketoconazole .