Mean treatment effects for pain severity ( mean change from baseline in the enzalutamide group -@ , @ % CI -@ to -@ , vs placebo @ , @ to @ ; difference -@ , @ % CI -@ to -@ ; p < @ ) and interference ( -@ , -@ to @ , vs @ , @ to @ ; respectively , difference -@ , @ % -@ to -@ ; p < @ ) were significantly better with enzalutamide than with placebo .