At the end of the study , the following significant differences -LSB- means ( @ % CIs ) -RSB- were seen between the synbiotic and placebo groups , respectively : ALT -LSB- -@ ( -@ , -@ ) compared with -@ ( -@ , -@ ) IU/L ; P < @ -RSB- , aspartate aminotransferase -LSB- -@ ( -@ , -@ ) compared with -@ ( -@ , -@ ) IU/L ; P < @ -RSB- , - glutamyltransferase -LSB- -@ ( -@ , -@ ) compared with -@ ( -@ , -@ ) IU/L ; P < @ -RSB- , high-sensitivity C-reactive protein -LSB- -@ ( -@ , -@ ) compared with -@ ( -@ , -@ ) mmol/L ; P < @ -RSB- , tumor necrosis factor - -LSB- -@ ( -@ , -@ ) compared with -@ ( -@ , -@ ) mmol/L ; P < @ -RSB- , total nuclear factor - B p@ -LSB- -@ ( -@ , -@ ) compared with @ ( -@ , -@ ) mmol/L ; P < @ -RSB- , and fibrosis score as determined by transient elastography -LSB- - @ ( -@ , -@ ) compared with -@ ( -@ , -@ ) kPa ; P < @ -RSB- .