The factors related to adherence when multifactorial intervention was applied were the number of exacerbations ( OR = @ ) , visits to health centre ( OR = @ ) and devices ( OR = @ ) ; illness severity ( OR = @ ) , beta-@-adrenergic ( OR = @ ) and xantine ( OR = @ ) treatment ; activity ( OR = @ ) and impact ( OR = @ ) scales of the Saint George Respiratory Questionnaire .