In multivariate analyses , adjusting for randomization arm , age , baseline IOP , central corneal thickness , pattern standard deviation , and HRT disc area , the following HRT parameters were associated with the development of OAG : the `` outside normal limits '' classification of the Frederick Mikelberg ( FSM ) discriminant function ( hazard ratio -LSB- HR -RSB- @ , @ % confidence interval -LSB- CI -RSB- : @-@ @ ) , larger mean cup depth ( HR @ , @ % CI : @-@ @ ) , cup-to-disc area ratio ( HR @ , @ % CI : @-@ @ ) , linear cup-to-disc ratio ( HR @ , @ % CI : @-@ @ ) , cup area ( HR @ , @ % CI : @-@ @ ) , smaller rim area ( HR @ , @ % CI : @-@ @ ) , larger cup volume ( HR @ , @ % CI : @-@ @ ) , smaller rim volume ( HR @ , @ % CI : @-@ @ ) , larger maximum cup depth ( HR @ , @ % CI : @-@ @ ) , and cup shape measure ( HR @ , @ % CI : @-@ @ ) .