Mean PRU remained significantly higher in the combined prasugrel groups versus the ticagrelor group ( least-squares mean difference : @ -LSB- @ % confidence interval @ to @ -RSB- ) and did not meet the primary noninferiority endpoint ( upper limit of the confidence interval @ ) , although PRU in the prasugrel cohort was lower at @ days than at @ or @ h. Accordingly , rates of high on-treatment platelet reactivity were higher at @ and @ h in both prasugrel groups .