Women with past PMD who were crossed over from estradiol to placebo experienced a significant increase in depression symptom severity demonstrated using the Center for Epidemiologic Studies-Depression Scale and @-item Hamilton Depression Rating Scale , with mean ( SD ) scores increasing from estradiol ( ie , @ -LSB- @ -RSB- and @ -LSB- @ -RSB- ) to placebo ( @ -LSB- @ -RSB- and @ -LSB- @ -RSB- , respectively -LSB- P = @ for both -RSB- ) .