In Study @ , eligible participants were randomly assigned to treatment with pioglitazone @ mg once daily ( QD ) alone for @ days followed by concomitant pioglitazone and topiramate ( titrated to @ mg BID ) from days @ to @ ( Group @ ) or to topiramate ( titrated to @ mg BID ) alone for @ days followed by concomitant pioglitazone @ mg QD and topiramate @ mg BID from days @ to @ ( Group @ ) .