Insulin ( LS : -@ U/mg -LSB- not significant -RSB- ; MR : -@ U/mg , P < @ ) and homeostasis model assessment of insulin resistance ( HOMA-IR ; LS -@ , P < @ ; MR : -@ , P < @ ) were also significantly lower following both interventions ; again improvements were more pronounced in the MR group ( insulin : P < @ ; HOMA P < @ ) CONCLUSION : It can be concluded that meal replacement is an effective intervention for rapid improvement of elevated fasting glucose and increased insulin concentrations , these being important biomarkers of the prediabetic state .