In the low-fat group , as compared to the G allele , the A allele tended to be related to the decrease in TC and LDL cholesterol concentrations -LSB- TC ( SE ) : -@ @ , P = @ ; LDL cholesterol : -@ @ , P = @ -RSB- and a lower increase in HDL cholesterol concentrations ( SE : -@ @ , P = @ ) , whereas an opposite effect in the high-fat diet group was evident -LSB- TC ( SE ) : @ @ , P = @ ; LDL cholesterol : @ @ , P = @ -RSB- , and there was no genetic effect on changes in HDL cholesterol concentrations ( P = @ ) .