Greater WMH volume at baseline , apolipoprotein E @ status , and smaller ECV at baseline were associated with an increased risk for aggressive decline ( hazard ratio -LSB- HR -RSB- , @ ; @ % CI , @-@ @ ; P = @ for WMH volume ; HR , @ ; @ % CI , @-@ @ ; P = @ for apolipoprotein E @ status ; HR , @ ; @ % CI , @-@ @ ; P < @ for ECV ) .