The primary endpoint was prostate tumor markers of cancer development and progression determined by tissue immunostaining of proliferation ( Ki@ ) , apoptosis ( Bcl-@ , Bax , Tunel ) , inflammation ( nuclear and cytoplasmic nuclear factor kappa B -LSB- NFB -RSB- ) and oxidation ( @-hydroxydeoxy-guanosine -LSB- @OHdG -RSB- ) .