Cariprazine also demonstrated statistically significant superiority over placebo on YMRS response ( @ % improvement : cariprazine , @ % ; placebo , @ % ; P = @ ) and remission ( YMRS total score@ : cariprazine , @ % ; placebo , @ % ; P = @ ) and mean change in CGI-S ( P = @ ) score and Positive and Negative Syndrome Scale ( PANSS ) ( P = @ ) total score .