At the baseline , compared to healthy controls , CHB patients had a lower circulating CD@ T cell frequency ( @ % @ % vs @ % @ % , P = @ ) and higher frequencies of programmed death @ positive CD@ T cells ( PD-@ + CD@ T ) ( @ % @ % vs @ % @ % , P = @ ) and CD@ + CD@ + FoxP@ + T regulatory cells ( Tregs ) ( @ % @ % vs @ % @ % , P = @ ) .