Within @ randomized , double-masked , phase @ clinical trials ( RIDE -LSB- A Study of Ranibizumab Injection in Subjects With Clinically Significant Macular Edema -LCB- ME -RCB- With Center Involvement Secondary to Diabetes Mellitus ; NCT@ -RSB- and RISE -LSB- A Study of Ranibizumab Injection in Subjects With Clinically Significant Macular Edema -LCB- ME -RCB- With Center Involvement Secondary to Diabetes Mellitus ; NCT@ -RSB- ) , the NEI VFQ-@ was administered at baseline and at the @ - , @ - , @ - , and @-month follow-up visits .