In the ripasudil-latanoprost study , those IOP reductions were -@ and -@ mm Hg at @ am for a difference of @ mm Hg ( @ % CI , -@ to @ mm Hg ; P = @ ) and -@ and -@ mm Hg at @ am for a difference of @ mm Hg ( @ % CI , @-@ @ mm Hg ; P < @ ) , respectively .