PANSS total score improvement at Week @ was statistically significant versus placebo for cariprazine @ mg/d , @ mg/d , and @ mg/d ( least squares mean difference -LSB- LSMD -RSB- : -@ , -@ , -@ , respectively ; p < @ ; LOCF ) and risperidone ( -@ , p < @ ; LOCF ) ; significant improvement on CGI-S was demonstrated for all active treatments ( p < @ ) .