The relationship between time to initiation of adjuvant chemotherapy ( TTC ) , calculated in weeks , and disease-free ( DFS ) or overall survival ( OS ) , was assessed in @ EBC patients with rapidly proliferating tumours ( thymidine labelling index > @ % or G@ or Ki@ > @ % ) , randomised in a phase III clinical trial ( NCT@ ) to receive chemotherapy with or without anthracyclines ( epirubicincyclophosphamide , methotrexate and fluorouracil ( CMF ) versus CMFepirubicin versus CMF ) .