Compared with baseline , the mean VMS frequency at week @ decreased to @ ( @ % CI , @-@ @ ) VMS per day ( @ % reduction ) in the estradiol group , to @ ( @ % CI , @-@ @ ) VMS per day ( @ % reduction ) in the venlafaxine group , and to @ ( @ % CI , @-@ @ ) VMS per day ( @ % reduction ) in the placebo group .