The most common grade @ and @ toxicities were alanine aminotransferase or aspartate aminotransferase increases ( one -LSB- @ % -RSB- in the interruption group vs three -LSB- @ % -RSB- in the continuation group ) , neutropenia ( two -LSB- @ % -RSB- vs two -LSB- @ % -RSB- ) , and intestinal occlusion ( one -LSB- @ % -RSB- vs one -LSB- @ % -RSB- ) .