Adult patients ( @ years of age ) with a first recurrence of a glioblastoma after temozolomide chemoradiotherapy were randomly allocated by a web-based program to treatment with oral lomustine @ mg/m ( @ ) once every @ weeks , intravenous bevacizumab @ mg/kg once every @ weeks , or combination treatment with lomustine @ mg/m ( @ ) every @ weeks and bevacizumab @ mg/kg every @ weeks .