Combined unique active lesions were lower in patients treated with subcutaneous IFN -@ a versus placebo ( mean ( SD ) lesions per patient per scan : three times a week @ ( @ ) ; once a week @ ( @ ) ; placebo @ ( @ ) ; reduction versus placebo : three times a week @ % ; once a week @ % ; p < @ ) and with three times a week versus once a week ( @ % reduction ; p = @ ) .