Patients were hepatitis B e antigen ( HBeAg ) - positive or HBeAg-negative , with levels of HBV DNA @ log@ IU/mL and lamivudine resistance mutations ( HBV polymerase or reverse transcriptase amino acid substitutions rtM@I/V rtL@M by INNO-LiPA Multi-DR v@ ; Innogenetics , Inc , Alpharetta , GA ) .