Several randomized controlled clinical trials of PTA balloons coated with different formulations of paclitaxel have been conducted in Europe ( N Engl J Med @ ; @:@ -@ ) ( Circulation @ ; @:@ -@ ) ( Circ Cardiovasc Interv @ ; @:@ -@ ) ( JACC Cardiovas Interv @ ; @:@ -@ ) and demonstrated more durable efficacy than PTA with comparable safety .