During long-term , NT-proBNP-guided therapy did not improve hospital-free ( primary end point : hazard ratio , @ ; @ % confidence interval , @-@ @ ; P = @ ) or overall survival ( hazard ratio , @ ; @ % confidence interval , @-@ @ ; P = @ ) but did improve HF hospitalization-free survival ( hazard ratio , @ ; @ % confidence interval , @-@ @ ; P = @ ) .