In a phase @ , multicenter , international , randomized , placebo-controlled , parallel-group , eight-group study , we evaluated the efficacy and safety of romosozumab over a @-month period in @ postmenopausal women , @ to @ years of age , who had low bone mineral density ( a T score of -@ or less at the lumbar spine , total hip , or femoral neck and -@ or more at each of the three sites ) .