Adalimumab responders demonstrated early downregulation of chemokine ( C-C motif ) ligand @ ( CCL@ ) mRNA ( mean -LSB- SE -RSB- at week @ , -@ -LSB- @ -RSB- , P < @ ; week @ , -@ -LSB- @ -RSB- , P < @ ) compared with late downregulation for methotrexate responders ( week @ , @ -LSB- @ -RSB- , P = @ ; week @ , -@ -LSB- @ -RSB- , P < @ ) .