More patients in the combination-therapy group than in the methotrexate-alone group or the placebo group met the criterion for the primary end point ( @ of @ -LSB- @ % -RSB- vs. @ of @ -LSB- @ % -RSB- and @ of @ -LSB- @ % -RSB- , respectively ; P = @ for combination therapy vs. methotrexate alone ; P < @ for combination therapy vs. placebo ) .