Biomarkers of inflammation , immunity , oxidative stress , and cardiac signaling underlying growth and inflammation ( extracellular signal-related kinase @/@ , p@ mitogen-activated protein kinase , mitogen-activated protein kinase kinases -LSB- MEK -RSB- @/@ and @/@ , c-Src ) , and apoptosis and survival ( c-Jun NH@-terminal kinases -LSB- JNK -RSB- , Bax/Bcl@ , Akt ) were assessed at @ , @ , @ , @ , and @ weeks post-CTX .