First , in an a priori substudy of a multicenter , randomized , double-blind , placebo-controlled trial of hydrocortisone ( @ mg/d for @ d ) in patients with severe trauma , we have measured the blood levels of five cytokines ( tumor necrosis factor - , interleukin-@ , interleukin-@ , interleukin-@ , interleukin-@ ) at day @ and day @ .