Mean changes between groups using generalized estimating equations and examined effects of weight-loss on LINE-@ methylation using stratified analyses ( gained weight/no weight-loss -LSB- N = @ -RSB- ; < @ % -LSB- N = @ -RSB- ; @ % -@ % -LSB- N = @ -RSB- ; > @ % of baseline weight-loss -LSB- N = @ -RSB- ) within each arm , adjusted by blood cell counts were compared .