In the ripasudil-timolol study , the mean IOP reductions from baseline in the ripasudil and placebo groups were -@ and -@ mm Hg at @ am for a difference of @ mm Hg ( @ % CI , @-@ @ mm Hg ; P < @ ) and -@ and -@ mm Hg at @ am for a difference of @ mm Hg ( @ % CI , @-@ @ mm Hg ; P < @ ) , respectively .