Grade @ or worse adverse events that were more common in the docetaxel plus nintedanib group than in the docetaxel plus placebo group were diarrhoea ( @ -LSB- @ % -RSB- of @ vs @ -LSB- @ % -RSB- of @ ) , reversible increases in alanine aminotransferase ( @ -LSB- @ % -RSB- vs six -LSB- @ % -RSB- ) , and reversible increases in aspartate aminotransferase ( @ -LSB- @ % -RSB- vs three -LSB- @ % -RSB- ) .