In all participants , pretreatment pain severity increased with every quartile increase in both the HMW : T-ADP ratio ( coefficient of variation -LSB- CV -RSB- @ ; @ % confidence interval -LSB- CI -RSB- : @ , @ ; p = @ ) and resistin levels ( CV @ ; @ % CI : @ , @ ; p = @ ) , but was not associated with quartile changes in leptin levels .