In this double-blind , placebo-controlled trial , we randomly assigned @ hypertensive participants with ADPKD ( @ to @ years of age , with an estimated glomerular filtration rate -LSB- GFR -RSB- > @ ml per minute per @ m ( @ ) of body-surface area ) to either a standard blood-pressure target ( @/@ to @/@ mm Hg ) or a low blood-pressure target ( @/@ to @/@ mm Hg ) and to either an angiotensin-converting-enzyme inhibitor ( lisinopril ) plus an angiotensin-receptor blocker ( telmisartan ) or lisinopril plus placebo .