In patients with a listed medical history of hypertension ( n = @,@ ) , least-squares mean ( LSM -LSB- standard error ( SE ) -RSB- ) changes from baseline to endpoint with placebo , tapentadol ER , and oxycodone HCl controlled release ( CR ) , respectively , were -@ ( @ ) , @ ( @ ) , and -@ ( @ ) beats per minute ( bpm ) for heart rate ; -@ ( @ ) , -@ ( @ ) , and -@ ( @ ) mmHg for SBP ; and -@ ( @ ) , -@ ( @ ) , and -@ ( @ ) mmHg for DBP ; in patients with at least one listed concomitant antihypertensive medication ( n = @,@ ) , the LSM ( SE ) changes from baseline to endpoint were -@ ( @ ) , @ ( @ ) , and -@ ( @ ) bpm for heart rate ; -@ ( @ ) , -@ ( @ ) , and -@ ( @ ) mmHg for SBP ; and -@ ( @ ) , -@ ( @ ) , and -@ ( @ ) mmHg for DBP .