Patients will receive either bivalirudin given as a @ mg/kg bolus followed immediately by a @-mg / kg per hour infusion for @ minutes prior to primary PCI and continued for @ hours after the end of the procedure at the reduced dose of @ mg/kg per hour , or heparins at guideline-recommended doses , with or without routine or bailout glycoprotein IIb/IIIa inhibitor treatment according to local practice .