Patients were randomly assigned to receive four cycles of PEB every @ weeks or two cycles of PEB followed by a high-dose sequence ( HDS ) comprising HD-cyclophosphamide ( @ g/m ( @ ) ) , @ courses of cisplatin and HD-etoposide ( @ g/m ( @ ) ) with stem-cell support , and a single course of HD-carboplatin -LSB- area under the curve ( AUC ) @ mg/ml min -RSB- with autologous stem-cell transplant .