In time-varying Cox analyses , women had a @ % lower rate of ischaemic CV events ( @ % CI @ % to @ % ) , in particular , more than @ % lower rate of stroke and coronary artery bypass grafting , and a @ % lower all-cause mortality ( @ % CI @ % to @ % ) , independent of active study treatment , age and hypertension , as well as time-varying valve area , low systolic function and abnormal LV geometry .