Grade @ treatment-emergent adverse events in the amrubicin and topotecan arms were : neutropenia ( @ % v @ % ; P = @ ) , thrombocytopenia ( @ % v @ % ; P < @ ) , anemia ( @ % v @ % ; P < @ ) , infections ( @ % v @ % ; P = @ ) , febrile neutropenia ( @ % v @ % ; P = @ ) , and cardiac disorders ( @ % v @ % ; P = @ ) ; transfusion rates were @ % and @ % ( P < @ ) , respectively .