Arg@Gly ADRB@ alleles were not associated with differences in the effects of tiotropium + ICS vs LABA+ICS ( hazard ratio for time to first exacerbation , @ -LSB- @ % CI , @ to @ -RSB- for Arg/Arg vs @ -LSB- @ % CI , @ to @ -RSB- for Arg/Gly or Gly/Gly , P = @ ) .