At week @ , anacetrapib reduced mean LDL-C concentration from @ mmol/L ( SD @ ) to @ mmol/L ( @ ; percentage change @ % -LSB- @ % CI -@ to -@ -RSB- compared with an increase with placebo from @ mmol/L ( @ ) to @ mmol/L ( @ ; percentage change @ % -LSB- -@ to @ -RSB- , with a difference in percentage change between anacetrapib and placebo of -@ % ( @ % CI -@ to -@ ; p < @ ) .