C-peptide incremental area under the curve ( AUC ) decreased by @,@ @ pmol/l min for @ h from pre to post Fr + active intervention ( P = @ ) leading to a decrease in plasma insulin total AUC ( pre : @,@ pmol/l ; post : @,@ pmol/l ; P = @ ) resulting in a decrease peak -LSB- Insulin -RSB- ( P = @ ) .