Complete clinical clearance at @ weeks occurred in @ of @ patients ( @ % ; @ % CI , @ % -@ % ) with placebo ; @ of @ ( @ % ; @ % CI , @ % -@ % ) with low-dose treatment ; @ of @ ( @ % ; @ % CI , @ % -@ % ) with middle-dose treatment ; and @ of @ ( @ % ; @ % CI , @ % -@ % ) with high-dose treatment ( P = @ ) .