In the SPS@ trial , patients with recent ( within @ months ) symptomatic lacunar infarcts from @ centres in North America , Latin America , and Spain were randomly assigned , in a two-by-two factorial design , to target levels of systolic blood pressure ( @:@ ; @-@ mm Hg vs < @ mm Hg ; open-label ) and to a once-daily antiplatelet treatment ( @:@ ; aspirin @ mg plus clopidogrel @ mg vs aspirin @ mg plus placebo ; double-blind ) .