Patients were randomized ( @:@:@:@ ) to receive standard of care , which consisted of definitive fracture fixation within seventy-two hours of injury with a locked intramedullary nail after reaming ; standard of care and injection with @ mg/mL of rhBMP-@ / CPM ; standard of care and injection with @ mg/mL of rhBMP-@ / CPM ; or standard of care and injection with buffer/CPM , to evaluate the activity of the CPM delivery matrix and provide for sponsor and investigator blinding .