Differences associated with pre-analytic factors averaged @ % @ % ; the three largest statistically significant changes ( @ % confidence interval ) were : PCT , +@ % ( +@ % to +@ % , p = @ ) with liver insufficiency ; ProADM , +@ % ( +@ % to +@ % , p < @ ) with age above median ; CRP , -@ % ( -@ % to -@ % , p = @ ) with steroid pretreatment .