Platelet activation ( - thromboglobulin -LSB- - TG -RSB- ) and thrombin generation ( prothrombin fragment @ + @ -LSB- F@ +@ -RSB- , thrombin-antithrombin complex -LSB- TAT -RSB- ) were studied in an open-label , randomized , parallel group trial in @ healthy male subjects ( n = @ per group ) who received ticagrelor and acetylsalicylic acid ( ASA ) in combination with dabigatran ( @ mg bid ) , rivaroxaban ( @ mg od ) or phenprocoumon ( INR @-@ @ ) .