After @ months of TMZ treatment , no changes were observed in LVEF ( @ @ % vs @ @ % ; P = @ ) , @MWT ( @ @ m vs @ @ m ; P = @ ) , maximum O@ uptake ( @ @ mL kg ( -@ ) min ( -@ ) vs @ @ mL kg ( -@ ) min ( -@ ) ; P = @ ) , functional class ( percentages of patients in functional classes I/II/III / IV @/@/@ vs @/@/@ / @ ; P = @ ) , or quality of life ( @ @ points vs @ @ points ; P = @ ) in TMZ versus placebo , respectively .