At Week @ with last observation carried forward , colesevelam produced a reduction in total low-density lipoprotein ( LDL ) particle concentration ( baseline : @,@ nmol/L ; least-squares -LSB- LS -RSB- mean treatment difference : -@ nmol/L , p < @ ) versus placebo ; reductions were also seen in large , small , and very small LDL particle concentrations ( all p < @ ) .