The most common grade @ or worse adverse events were increased lipase ( @ -LSB- @ % -RSB- of @ patients in the orteronel plus prednisone group vs @ -LSB- @ % -RSB- of @ patients in the placebo plus prednisone group ) , increased amylase ( @ -LSB- @ % -RSB- vs nine -LSB- @ % -RSB- ) , fatigue ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) , and pulmonary embolism ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) .