Increased daytime glucose Rd ( @ -LSB- @ , @ -RSB- vs @ -LSB- @ , @ -RSB- mol/kg/min , P = @ ) and decreased overnight Rd ( @ -LSB- @ , @ -RSB- vs @ -LSB- @ , @ -RSB- mol/kg/min , P = @ ) were observed when the usual therapy was discontinued , whereas daytime peripheral insulin sensitivity was reduced ( @ -LSB- @ , @ -RSB- vs @ -LSB- @ , @ -RSB- nmol/kg/min per pmol/L , P = @ ) .