In addition , with colesevelam there was an increase in total high-density lipoprotein ( HDL ) particle concentration versus placebo ( baseline : @mol/L ; LS mean treatment difference : +@ mol/L , p = @ ) , due to increases in the large ( baseline : @mol/L ; LS mean treatment difference : +@ mol/L , p = @ ) and medium ( baseline : @mol/L ; LS mean treatment difference : +@ mol/L , p = @ ) HDL subclasses .