Among patients aged @ years , the adjusted hazard ratio ( HR ) for survival without grade @-@ toxicity ( HR @ , @ % confidence interval -LSB- CI -RSB- @-@ @ ) favored pemetrexed + carboplatin ; this was similar to the HRs in patients aged @ years ( HR @ , @ % CI @-@ @ ) , patients aged < @ years ( HR @ , @ % CI @-@ @ ) , and the Q-ITT population ( HR @ , @ % CI @-@ @ ) .