In a @-month open-label pilot study , @ adult patients with ADPKD were randomly assigned to low-dose ( LD ) rapamycin ( rapamycin trough blood level , @-@ ng/ml ) ( LD group , n = @ ) , standard-dose ( STD ) rapamycin trough level ( > @-@ ng/ml ) ( STD group , n = @ ) , or standard care ( SC group , n = @ ) .