In patients untreated with ICS at baseline , Arg@Gly and Arg@Arg genotypes were associated with significantly prolonged time to first exacerbation compared with Gly@Gly ( vs Arg@Gly p = @ ; Arg@Arg p = @ ; proportion of patients with at least one exacerbation was @ % in Arg@Arg , @ % in Arg@Gly , and @ % in Gly@Gly ) , whereas in patients on ICS at baseline , only the Arg@Arg genotype was associated with significantly prolonged time to first exacerbation compared with Gly@Gly ( p = @ ; not Arg@Gly p = @ ; proportion of patients with at least one exacerbation was @ % in Arg@Arg , @ % in Arg@Gly , and @ % in Gly@Gly ) .