Vytorin mostly altered the expression levels of genes related to inflammation/oxidative stress ; it downregulated the NF-KappaB and upregulated the expression of anti-inflammatory cytokine , IL-@ , and anti-oxidant enzymes , GPX@ and SOD@ , but also upregulated the expression levels of genes involved in cellular activation , adhesion , and coagulation cascade , including VWF , F@ , PF@ , PF@V@ SELP , ITGB@ , ITGB@ .