Change rate of IMT statistical positively related to descent rates of Th@ cells frequency , IL-@ , IL-@ , IL-@ , TNF - , expression of RORt mRNA , Th@/Treg ratio , IL-@ , IL-@ , IFN - , hsCRP , and MCP-@ , and negatively related to increased rates of Treg frequency , IL-@ , TGF-@ , and expression of Foxp@ mRNA , respectively ( all P < @ ) .