In large follicles , hCG supplementation induced a nearly @-fold increase of estradiol ( nanomoles per liter ) -LSB- D@ : @ ; D@ : @ ; D@ : @ ; D@ : @ ( P < @ ) -RSB- , a significant @-fold increase of androstenedione , and a @-fold increase of T ( nanomoles per liter ) -LSB- D@ : @ ; D@ : @ ; D@ : @ ; D@ : @ ( P < @ ) -RSB- .