This randomized , double-blind , placebo-controlled study compared the effects of three oral regimens administered for @days , i.e. , placebo ; aspirin ( @mg twice daily ) and simvastatin ( @mg twice daily ) ; aspirin , simvastatin , and the sodium salt of R - - lipoic acid ( NaRLA , @mg three times daily ) on markers of HO-@ activation ( i.e. , plasma HO-@ protein concentration and venous monocyte HO-@ protein activity ) in @ healthy subjects ( @ females ) .