Compared with beclometasone-formoterol plus salbutamol as needed , beclometasone-formoterol for both maintenance and reliever treatment significantly increased the time to first exacerbation ( @ days vs @ days ) by @ days , with a @ % reduction in risk ( hazard ratio @ -LSB- @ % CI @ to @ -RSB- ; p = @ ) , and the estimated probability was @ % and @ % , respectively ( p = @ ) .