While the authors consider an improvement of @ or more to be clinically meaningful , the changes from baseline in mean SNOT-@ scores of those treated with irrigation ( and the differences with those treated with nasal spray ) at @ , @ , and @ weeks were @ ( difference @ , -LSB- @ % confidence interval -@ to @ -RSB- ) , @ ( difference @ -LSB- @ to @ -RSB- ) , and @ ( difference @ -LSB- @ to @ -RSB- ) , respectively .