The mean ( @ % CI ) decreases versus placebo in nighttime SBP were statistically significant with all @ etamicastat doses ( @ mg , -@ mm Hg -LSB- -@ to -@ ; P < @ -RSB- ; @ mg , -@ mm Hg -LSB- -@ to -@ ; P < @ -RSB- ; and @ mg , -@ mm Hg -LSB- -@ to -@ ; P < @ -RSB- ) .