For this international , multicentre , open-label , non-inferiority , phase @ , randomised SIOP WT @ trial , we recruited children aged @ months to @ years at the time of diagnosis of a primary renal tumour from @ hospitals in @ countries who had received @ weeks of preoperative chemotherapy with vincristine and actinomycin D. Children with stage II-III intermediate-risk Wilms ' tumours assessed after delayed nephrectomy were randomly assigned ( @:@ ) by a minimisation technique to receive vincristine @ mg/m ( @ ) at weeks @-@ , @ , @ , @ , @ , @ , @ , @ , @ , @ , @ , @ , and @ , plus actinomycin D @ g/kg every @ weeks from week @ , either with five doses of doxorubicin @ mg/m ( @ ) given every @ weeks from week @ ( standard treatment ) or without doxorubicin ( experimental treatment ) .