The effect of doubling the clopidogrel MD on relative change in RPA was neutralized by lansoprazole ( -@ % versus +@ % without and with lansoprazole , respectively , p = @ ) whereas @ mg of prasugrel MD dramatically reduced RPA irrespective of lansoprazole co-administration ( -@ % @ % vs. -@ % @ % without and with lansoprazole , respectively , p = NS ) .