Three mg/kg pioglitazone significantly improved insulin sensitivity ( geometric mean -LSB- @ % CI -RSB- @ -LSB- @-@ @ -RSB- to @ -LSB- @-@ @ -RSB- minpmolL ; P = @ versus change with placebo ) , reduced insulin area under the curve during IVGTT ( geometric mean -LSB- range -RSB- @ -LSB- @-@ -RSB- to @ -LSB- @-@ -RSB- minnmol/L ; P = @ versus change with placebo ) , and lowered serum triglyceride ( geometric mean -LSB- range -RSB- @ -LSB- @-@ -RSB- to @ -LSB- @-@ -RSB- mg/dL ; P = @ versus change with placebo ) and cholesterol ( geometric mean -LSB- range -RSB- @ -LSB- @-@ -RSB- to @ -LSB- @-@ -RSB- mg/dL ; P = @ versus change with placebo ) concentrations in the obese cats .