The DPYD * @A variant statistically significantly associated with the specific AEs nausea/vomiting ( P = @ ) and neutropenia ( P < @ ) , whereas D@V statistically significantly associated with dehydration ( P = @ ) , diarrhea ( P = @ ) , leukopenia ( P = @ ) , neutropenia ( P < @ ) , and thrombocytopenia ( P < @ ) .