Compared with participants without HA , those with HA had marginally significant less atrophy ( less decrease in TBV ) from baseline to @ months ( -@ -LSB- @ % CI -@ , -@ -RSB- vs. -@ -LSB- @ % CI -@ , -@ -RSB- , P = @ ) , and no significant increase of AWM volume ( @ -LSB- @ % CI @ , @ -RSB- vs. @ -LSB- @ % CI @ , @ -RSB- , P = @ ) .