GH dosing titrated to an IGF-I target of @ SDS was the most dose-sparing treatment regimen for GHD or ISS children ( meanSE HSDS/GH dose ratios @ @ and @ @ , respectively ) compared with conventional dosing ( @ @ and @ @ , respectively ; P = @ , P = @ ) and IGF@T ( @ @ and @ @ , respectively ; P = @ , P < @ ) .