High VEGFC was a negative prognostic factor for disease-free survival -LSB- hazard ratio ( HR ) = @ , @ % confidence interval ( CI ) = @-@ @ , Wald 's p = @ -RSB- , with a trend for overall survival ( HR = @ , @ % CI = @-@ @ , p = @ ) in patients treated with E-CMF adjusted for clinicopathological characteristics , while high VEGFR@ was associated with increased risk for death , yet non significantly in patients with HER@-negative disease ( HR = @ , @ % CI = @-@ @ , p = @ ) , regardless of treatment .