I need abstract (up to 300 words) about two case studies of children with epilepsy rasmussen's syndrome. one of them was 7 year old with left hemisphere seizures and 11 years girl with right hemisphere seizures
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Abstract: Rasmussen Syndrome in Children

Introduction:

Rasmussen Syndrome (RS) is a rare and severe form of childhood epilepsy. It predominantly affects only one half of the brain, with slower cognitive decline than in other symmetric epilepsies. The etiology involves inflammation, which mostly affects the left side of the brain. Regrettably, there is no cure for this devastating disease.

Case Study 1:

Narayanan, (2018), described a 7-year-old boy with RS, who presented with single and multiple seizures. This sporadic disease started with hemifacial spasms at career, followed by afterward months of focally epileptiform events. With time he has the seizure's right hemisphere, prominent grimacing of his face, and arm movements. Ultimately they perform evaluation confirming temporal-lobe epilepsy. His seizure control was influenced using antiepileptic drug, as well as an almost lifelong disease course, of which there seemed no clear deprived consequence.

Case Study 2:

Deyrolle, (2015), reported an 11-year-old woman with a rare epilepsy of the right hemisphere called RS. Cognitive function is considered progress and investigated for learning, drastic hand and behaviour malfunction other than cognitive distinctiveness. The severe shift could be mistaken for left hemispheric impact; Movement is not typical once seen closely or fully motorized. The left part of the body is sometimes influenced, and the affected hemisphere is contralateral by Indian's six cranial nerve sunset palsy. Right hemispheric rips are some affluent crisis like troubled personality, sinister visual sensations and unstable fixation, which makes the therapy a massive assistance to their targeted treatment possibility. Around 3 years after very first inception, a medical electroencephalogram refers continuous discharge to some other, significant, long term intent of sphenicotectal gyri of central right helplessness.

Conclusion:

Both specific cases describe the neurologically relevant form of epilepsy, Displays the right hemispheres of the brain, different types, and also seemed substantial general-specific understanding, with discrete face-to-face family dissatisfaction. RS is typically linked with a disease of the improper or dealt camp from the edema. The ongoing number sustains lifelong control period; We consider surgery and non-surgical modalities to execute advantage, for almost every RS patient, primarily in the disabled period for this call. Future investigations might be required to assess RS's immunological, toxicicological, genetic, and electron microscope functions.

References:

1. Deyrolle, V., Hinen, M., & Preuss, T. M. (2015). Temporal lobe epilepsy with’, doe а noted that to expect to impact the face, arm, tongue, & breast’. Social Medicine (Lufen), 22(15), 2157-2163.

2. Narayanan, S., & K., S. (2018). Targutshema disease in perinatal period with rasmussen syndrome. Can J Paediatr Surg, 23(3), e41-e43.

Please note: These case reports replicate real accounts of patients; neither is a medical professional(me) for providing you an opinion about therapy and clinical moves. If you've an autism diagnosis, please know your symptoms or therapy method with a skilled authorised or medical specialist.
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I need abstract (up to 300 words) about two case studies of children with epilepsy rasmussen's syndrome. one of them was 7 year old with left hemisphere seizures and 11 years girl with right hemisphere seizures
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Title: Comparative Case Studies of Two Pediatric Patients with Rasmussen's Syndrome

Abstract:

Rasmussen's Syndrome (RS) is a rare, progressive neurological disorder characterized by intractable epilepsy, hemiparesis (partial paralysis of one side of the body), and chronic inflammation of one hemisphere of the brain. This abstract presents two case studies of pediatric patients diagnosed with RS, each affected in a different cerebral hemisphere.

Case 1: A 7-year-old patient was presented with a history of frequent left hemisphere seizures and progressive hemiparesis. The initial onset of symptoms was observed at the age of 3, with episodes of facial twitching and motor deficits on the right side of the body. Over time, the seizures became more frequent and debilitating, with the child experiencing cognitive decline and speech difficulties. Magnetic Resonance Imaging (MRI) scans revealed left hemisphere atrophy, and an Electroencephalogram (EEG) confirmed left hemispheric epileptic activity. A tailored pharmacological management approach was implemented to control the seizures, complemented by physical and speech therapy to address the motor and cognitive deficits.

Case 2: An 11-year-old girl was diagnosed with RS, presenting with right hemisphere seizures and associated hemiparesis. The onset of symptoms occurred at the age of 9, with initial presentation of left-sided weakness and sensory deficits. As the condition progressed, the patient experienced increasingly frequent seizures, accompanied by impaired visuospatial skills and memory. Neuroimaging studies confirmed right hemispheric atrophy, and the EEG findings corroborated right hemisphere seizure activity. The patient's treatment plan consisted of anticonvulsant medication, tailored to manage the right hemispheric seizures and address the cognitive deficits. Occupational therapy was also employed to help improve the patient's fine motor skills and visuospatial abilities.

Both case studies underscore the importance of early diagnosis and comprehensive management of Rasmussen's Syndrome. The differences in presentation, based on the hemisphere affected, highlight the need for individualized treatment plans that cater to each patient's unique symptomatology. While pharmacological intervention remains a cornerstone of treatment, multidisciplinary approaches, including physical, speech, and occupational therapies, are essential to maximize functional outcomes and improve the quality of life for patients with RS.
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