l  alkaline phosphatase (ap) l  aspartate transaminase (ast jew sgot) u l  alanine transaminase (alt jew sgpt) għandhom ikunu ≤ 3 darbiet il limitu massimu tan normal alkaline phosphatase ast u alt ≤ 5 darbiet il limitu massimu tan normal hu aċċettabbli jekk il fwied ikun sit ta  metastasi f każ ta  tumur