spielmann h mailtohoffmann s liebsch m botham p fentem j eskes c roguet r cotovio j cole t worth a heylings j jones p robles c kandárová h mailtogamer a remmele m curren r raabe h cockshott a gerner i u zuang v (2007) the ecvam international validation study on in vitro tests for acute skin irritation report on the validity of the episkin and epiderm assays and on the skin integrity function test atla 35 559601