it tneħħija totali ta  paliperidone naqset bi 32 f suġġetti b indeboliment renali ħafif (tneħħija tal kreatinina [crcl] = 50 to < 80 ml/ min) b 64 f indeboliment moderat (crcl = 30 to < 50 ml/ min) u 71 f indeboliment sever (crcl = < 30 ml/ min)