f konċentrazzjonijiet terapewtiċi febuxostat ma jinibixxix enżimi oħra involuti fil metaboliżmu ta  purine jew ta  pyrimidine jiġifieri guanine deaminase hypoxanthine guanine phosphoribosyltransferase orotate phosphoribosyltransferase orotidine monophosphate decarboxylase jew purine nucleoside phosphorylase