Table 2 displays the ApoAIV 360 allelic distribution according to e4-allele presence between AD patients and elderly control groups.

Regarding apoAIV(360:His), it has been suggested that it may modulate aging-associated functions and needs further investigation in longevity studies [24]. Apolipoprotein AIV has various functions such as LCAT activation, binding to lipoprotein receptor sites, promoting cholesterol efflux from adipose cells, etc. [9][11][12][14]. Our results indicate that apoAIV(360:His) may be more hydrophobic, efficient in LCAT activation, and better linked to lipoproteins, which may protect against cardio and cerebrovascular diseases.

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