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significance levels were nominal and uncorrected for multiple testing.

Since this cohort consisted of two ethnic groups, one homogenous and the second characterized by heterogeneity, it is not surprising that a more consistent pattern of association was observed in the Ashkenazi cohort. We genotyped approximately 400 DNA samples in our older cohort. However, by stratifying this sample by ethnicity as well as gender considerable power was lost. Future studies in this population would gainfully focus solely on the more homogenous Ashkenazi ethnic group. Moreover, since it would be of considerable interest to compare simultaneously the risk for all examined polymorphisms a substantially larger population sample should be targeted.

Acknowledgement

This research was partially supported by the Israel Science Foundation founded by the Israel Academy of Sciences and Humanities (RPE).

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