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longevity-associated quantitative modulation of Lp(a) by the polymorphism of apo A-IV.

In conclusion, our analysis of genetic and biochemi- cal parameters has revealed new longevity-associated features. The high frequency of the HinfI((cid:27):(cid:27)) poly- morphism of apo A-IV, the low level of LDL-C and, especially, the high Lp(a) concentration found in cente- narians add further elements to the biological ‘longevity pattern’. We suggest that the combination of genetic factors, such as the apo A-IV alleles with their possible impact on the circulating lipoproteins, the Lp(a) con- centration and, perhaps, the apo(a) isoforms, together with non-genetic factors, characterize some individuals in a population, conferring a biological advantage which selects them for long and healthy survival. Cente- narians represent a unique model to inspect on the basis of longevity. The availability of another homoge- neous group of study has offered to our group an important opportunity to gain better insight into the biological processes of aging.

Acknowledgements

We thank Mr Vito Cataldo for the reproductions. This work was supported by the CNR-Targeted Aging Project grants No. 95.982.PF40, 95.973.PF40, 95.988.PF40 code no. 981740 and by MURST grants. The financial support of Telethon-Italy (G. Pepe-grant No. 951) is also gratefully acknowledged.

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