(cid:31)@@2

Table

TH-STR/INS-FokI | I linkage ¢ > disequilibrium z 1 analysis ( 6(cid:1)7 )inr 1 males. 1 . TH-STR a alleles z sare i > indicated a 1 as ¢ @& 3& 2&3&(cid:31)0(cid:1)& (cid:31)0& according | tot ) the 1 ee EINES» repeat | MoM Mme| number. ae10° i is | the i pee FOLD NEA IES- imperfect | | HUMTHO1 | allele (cid:31)0 ) (Puers « et i (cid:17)(cid:10)!& (cid:31)33/7! >B9 indicate IIE IDE DINEabsence/presence ¢ (cid:11)* peerf the 1 > restriction s   aN NE. Haplotypic > frequencies ¢ ; estimated | aNI by ! Cees Ae; Maximum I Abey AAA MPO aM1 Likelihood ( 6#%=7 ) and ISS EESexpected ( 6=I97 ) under t r the 1 > null | EE IIE IN| hypothesis  SI 0

Haplotype (cid:30)0(cid:23)A0 ) year « r old s | subjects (     - 119) (cid:31)00(cid:23)(cid:31)03  ) year « r old s | subjects (   : 72) #%= =I9  #%= =I9  @> 0!(cid:30)// 0!(cid:30)(cid:31)@  0!0(cid:31)A 0!(cid:30)D 0!(cid:30)0/  0!0D(cid:30) @9 0!0(cid:30)@ 0!0D/  0!0(cid:31)A 0!0(cid:31)0 0!0  —( 0!0D(cid:30) A> 0.212 0!(cid:31)AA  0!0/ 0!(cid:31)/@ 0!(cid:31)(cid:31)D  0!0(cid:30)(cid:30) A9 0!000 0!0/  0!0/ 0!00A 0!0(cid:30)3 —( 0!0(cid:30)(cid:30) 2> 0!03 0!0A3  0!0(cid:31)@ 0!03(cid:30) 0!0A/  0!0(cid:31)3 29 0!000 0!0(cid:31)@  0!0(cid:31)@ 0!000 0!0(cid:31)3  0!0(cid:31)3 3> 0!(cid:30)0@ 0!(cid:31)20  0!0(cid:30)@ 0!(cid:31)3(cid:31) 0!(cid:31)   0!0/3 39 0!0(cid:31)0 0!0/@  0!0(cid:30)@ 0!000 0!0/3 —( 0!0/3 (cid:31)0(cid:1)> 0!0A(cid:30) 0!(cid:31)@A  0!03 0!033 0!(cid:30)(cid:30)A  0!(cid:31)(cid:30)2 (cid:31)0(cid:1)9 0!(cid:31)(cid:30)2 0!0//  0!03 0!(cid:31)2@ 0!0 2  0!(cid:31)(cid:30)2 (cid:31)0> 0!0(cid:31)2 0!0(cid:31) + ( 0!00/ 0!0/D 0!0(cid:30)A + ( 0!00A (cid:31)09 0!000 0!00/  0!00/ 0!000 0!00A  0!00A Total (cid:31)!000 (cid:31)!000 0!000 (cid:31)!000 (cid:31)!000 0!000

Table ¢ @

TH-STR/IGF2-Avall | I linkage c > disequilibrium < 1 analysis ( 6(cid:1)7 )inr 1 males. 1 . TH-STR « alleles < S are i > indicated a Jas ¢ @& 3& 2& 3& (cid:31)0(cid:1)& (cid:31)0& , according t   ) the 1 ae Nes> repeat 1 oyet number. | ane10° i ist s the i PROD ODO NEAL- imperfect | JEL OES IDI AEEt HUMTHO1 : | allele | (cid:31)0 ) (Puers «  (cid:17)(cid:10)!& (cid:31)33/7! >B9 > indicate ee IDES ODD BIDSabsence/presence ¢ (cid:11)* carsf the 1 > restriction s  site. I  ae hee eee. Haplotypic > frequencies ¢ ; estimated | I by ! ve OMe; Maximum I hey DA AS o”1 Likelihood ( 6#%=7 ) and NS ANNE Eeexpected ( 6=I97 ) under t r the 1 > null | EE INN AE| hypothesis  ee |= 0

Haplotype (cid:30)0(cid:23)A0  ) year «  r old s | subjects (     - 119) (cid:31)00(cid:23)(cid:31)03  ) year «  r old s | subjects (   : 72) #%= =I9  #%= =I9  @> 0!(cid:30)D/ 0!(cid:31)AD  0!0@3 0!(cid:30)@D 0!(cid:30)(cid:31)3  0!0D @9 0!0(cid:31)@ 0!02  0!0@3 0!0D3 0!03D —( 0!0D A> 0!(cid:31)00 0!(cid:31)0(cid:31)  0!00(cid:31) 0!(cid:31)22 0!(cid:31)/@  0!0  A9 0!0 S1 0!0 0  0!00(cid:31) 0!00@ 0!0 2 —( 0!0  2> 0.122 0!030  0!0/(cid:30) 0!03A 0.112  0!0(cid:31) 29 0!0(cid:31)/ 0!0D  0!0/(cid:30) 0!0@/ 0!0D2  0!0(cid:31) 3> 0!0A@ 0!(cid:31) @  0!020 0!0(cid:30)(cid:31) 0!(cid:31)0(cid:30) —( 0!02(cid:31) 39 0!(cid:31) @ 0!0A@  0!020 0!(cid:31)(cid:30) 0!0DD  0!02(cid:31) (cid:31)0(cid:1)> 0.122 0!(cid:31)(cid:30)A  0!00 0!(cid:31)/(cid:30) 0!(cid:31)/(cid:30) 0!000 (cid:31)0(cid:1)9 0!0@A 0!0@(cid:30)  0!00 0!0 0!0 0!000 (cid:31)0> 0!003 0!0(cid:30)/  0!0(cid:31)D    (cid:31)09 0!0(cid:30) 0!0(cid:31)(cid:31)  0!0(cid:31)D    Total (cid:31)!000 (cid:31)!000 0!000 (cid:31)!000 (cid:31)!000 0!000

Table ° A

TH-STR/IGF2-Avall | [ linkage « > disequilibrium : 1 analysis ( 6(cid:1)7 ) inf   . TH-STR « . alleles < are i > indicated las ¢ @& 3& 2& 3& (cid:31)0(cid:1)& (cid:31)0 ) according t x tot > the r ee> repeat r —— eest number. | we10° i  ist s the i CNN DED NEAR OEM> imperfect t HUMTHO1 z | allele | (cid:31)0 ) (Puers e ete  (cid:17)(cid:10)!& (cid:31)33/7! >B9 > indicate ae EN eNOS *absence/presence « (cid:11)* f the 1 ae ee> restriction s 1 site. ] NN OE. Haplotypic 1 ‘peeihes hae’> frequencies ¢ ; estimated | I by! aye eee; Maximum | he RED A AA Ye 21 Likelihood ( 6#%=7 ) and EI ESexpected ( 6=I97 ) under t r the 1 > null | | hypothesis J sD = we | 0

Haplotype (cid:30)0(cid:23)A0 ) year ¢ r old s | subjects ( s(n   (cid:31)/A(cid:3) (cid:31)00(cid:23)(cid:31)03  ) year ¢ r old s | subjects (    (cid:31)DA(cid:3) #%= =I9  #%= =I9  @> 0!(cid:30)/D 0!(cid:31)A  0!0 3 0!(cid:30)/2 0!(cid:31)@0  0!0A2 @9 0!0(cid:30) 0!02D —( 0!0 3 0!0(cid:31)A 0!03  0!0A2 A> 0!(cid:31)A3 0!(cid:31)D/  0!0/@ 0!(cid:31)(cid:30)@ 0!030  0!0/@ A9 0!0// 0!0@3 —( 0!0/@ 0!0(cid:31)A 0!0 /  0!0/@ 2> 0!0@3 0!0@D  0!00 0!0 2 0!0 2 0!000 29 0!0(cid:30)@ 0!0/(cid:31)  0!00 0!0/D 0!0/D 0!000 3> 0!0// 0!(cid:31)D@  0!(cid:31)(cid:31)/ 0!0(cid:30)0 0!(cid:31)(cid:30)0  0!(cid:31)00 39 0!(cid:31)2/ 0!0A0  0!(cid:31)(cid:31)/ 0!(cid:31)A0 0!0A0  0!(cid:31)00 (cid:31)0(cid:1)> 0!(cid:31) A 0!(cid:31)/@  0!0(cid:30)(cid:31) 0!(cid:31)2D 0!(cid:31)20  0!00D (cid:31)0(cid:1)9 0!0DD 0!0@ —( 0!0(cid:30)(cid:31) 0!(cid:31)0(cid:30) 0!(cid:31)0  0!00D (cid:31)0> 0!00(cid:30) 0!0(cid:31)(cid:31)  0!003 0!00/ 0!0(cid:30)(cid:31)  0!0(cid:31)2 (cid:31)09 0!0(cid:31) 0!00@  0!003 0!0/(cid:31) 0!0(cid:31)/  0!0(cid:31)2 Total (cid:31)!000 (cid:31)!000 0!000 (cid:31)!000 (cid:31)!000 0!000

 | significant « difference ° was | found | | both : for’ -TH-INS |    0(cid:1)00(cid:31)(cid:3) ) and | | for’ * TH-IGF2 |   0(cid:1)0/(cid:30)(cid:3) RRA CALAN MARAE) haplotypes, t ew, thus s “weg ae 8; suggesting : pM AR Ra RRr SeX-Specific  RN> survival { te| factors s wap eae aM; spanning t a4r the ¢ ahaentire 1 ‘region.