–

Depp CA, Jeste DV (

) Definitions and predictors of suc- cessful aging: a comprehensive review of larger quantita- tive studies. Am J Geriatr Psychiatry

:

–

Epstein MP, Duren WL, Boehnke M (

) Improved inference of relationship for pairs of individuals. Am J Hum Genet

:

–

Farrer LA, Conneally PM, Yu PL (

) The natural history of Huntington’s disease: possible role of “aging genes”. Am J Med Genet

:

–

Glatt SJ, Chayavichitsilp P, Depp C, Schork NJ, Jeste DV (

) Successful aging: from phenotype to genotype. Biol Psychiatry

:

–

Hahs DW, M

auley JL, Crunk AE, M

arland LL, Gaskell PC, Jiang L, Slifer SH, Vance JM, Scott WK, Welsh- Bohmer KA, Johnson SR, Jackson CE, Pericak-Vance MA, Haines JL (

) A genome-wide linkage analysis of dementia in the Amish. Am J Med Genet B Neuro- psychiatr Genet

B:

–

Katz S (

) Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. J Am Geriatr Soc

:

–

Kehler J (

) PDE

A inhibitors: novel therapeutic drugs for schizophrenia. Curr Pharm Des

:

–

Khachaturian AS, Gallo JJ, Breitner JC (

) Performance characteristics of a two-stage dementia screen in a popula- tion sample. J Clin Epidemiol

:

–

Kleiman RJ, Kimmel LH, Bove SE, Lanz TA, Harms JF, Romegialli A, Miller KS, Willis A, des Estages S, Kuhn M, Schmidt CJ (

) Chronic suppression of phosphodiester- ase

A alters striatal expression of genes responsible for neurotransmitter synthesis, neurotransmission, and signaling pathways implicated in Huntington’s disease. J Pharmacol Exp Ther

:

–

Kleindorp R, Flachsbart F, Puca AA, Malovini A, Schreiber S, Nebel A (

) Candidate gene study of FOXO

, FOXO

, and FOXO

reveals no association with human longevity in Germans. Aging Cell

:

–

further study in this sample to identify functional variations in genes such as QKI, PDE10A, and other genes in the region that might be responsible for promoting SA in these individuals.

Acknowledgments We acknowledge the of the Vanderbilt CHGR DNA Resources core for processing some of the sam- ples. Some of the samples used in this study were collected while WKS, JRG, and MAP-V were faculty members at Duke University. This work supported by NIH grants AG019085 to Jonathan L. Haines and AG019726 to William K. Scott.

References

References Abecasis GR, Cherny SS, Cookson WO, Cardon LR (

) Merlin—rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet

:

–

Agarwala R, Biesecker LG, Schaffer AA (

) Anabaptist genealogy database. Am J Med Genet C Semin Med Genet

C:

–

Arcos-Burgos M, Muenke M (

) Genetics of population isolates. Clin Genet

:

–

Arking DE, Atzmon G, Arking A, Barzilai N, Dietz HC (

) Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pres- sure, stroke, and longevity. Circ Res

:

–

Arnaud-Lopez L, Usala G, Ceresini G, Mitchell BD, Pilia MG, Piras MG, Sestu N, Maschio A, Busonero F, Albai G, Dei M, Lai S, Mulas A, Crisponi L, Tanaka T, Bandinelli S, Guralnik JM, Loi A, Balaci L, Sole G, Prinzis A, Mariotti S, Shuldiner AR, Cao A, Schlessinger D, Uda M, Abecasis GR, Nagaraja R, Sanna S, Naitza S (

) Phosphodies- terase

B gene variants are associated with serum TSH levels and thyroid function. Am J Hum Genet

:

–

Atzmon G, Barzilai N, Hollowell JG, Surks MI, Gabriely I (

a) Extreme longevity is associated with increased serum thyrotropin. J Clin Endocrinol Metab

:

–

Atzmon G, Barzilai N, Surks MI, Gabriely I (

b) Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity. J Clin Endocrinol Metab

:

–

Banasik K, Ribel-Madsen R, Gjesing AP, Wegner L, Andersson A, Poulsen P, Borglykke A, Witte DR, Pedersen O, Hansen T, Vaag A (

) The FOXO

A rs

G-allele asso- ciates with improved peripheral and hepatic insulin sensi- tivity and increased skeletal muscle-FOXO

A

NA expression in twins. J Clin Endocrinol Metab

:E

– E

Capurso C, Solfrizzi V, D’Introno A, Colacicco AM, Capurso SA, Semeraro C, Capurso A, Panza F (

) Interleukin

-

G/C promoter gene polymorphism in centenarians: no evidence of association with human longevity or interac- tion with apolipoprotein E alleles. Exp Gerontol

:

–

Carmelli D, Kelly-Hayes M, Wolf PA, Swan GE, Jack LM, Reed T, Guralnik JM (

) The contribution of genetic

AGE (

)

:

–

Korn JM, Kuruvilla FG, M

arroll SA, Wysoker A, Nemesh J, Cawley S, Hubbell E, Veitch J, Collins PJ, Darvishi K, Lee C, Nizzari MM, Gabriel SB, Purcell S, Daly MJ, Altshuler D (

) Integrated genotype calling and association anal- ysis of SNPs, common copy number polymorphisms and rare CNVs. Nat Genet

:

–

Lawton MP, Brody EM (

) Assessment of older people: self- maintaining and instrumental activities of daily living. Gerontologist

:

–

Li C, Wu W, Jin H, Zhang X, Xue H, He Y, Xiao S, Jeste DV, Zhang M (

) Successful aging in Shanghai, China: definition, distribution, and related factors. Int Psychoger- iatr

:

–

Li Y, Wang WJ, Cao H, Lu J, Wu C, Hu FY, Guo J, Zhao L, Yang F, Zhang YX, L

, Zheng GY, Cui H, Chen X,Zhu Z, He H, Dong B, Mo X, Zeng Y, Tian XL (

) Genetic association of FOXO

A and FOXO

A with longevity trait in Han Chinese populations. Hum Mol Genet

:

–

Liu F, Kirichenko A, Axenovich TI, van Duijn CM, Aulchenko YS (

) An approach for cutting large and complex ped- igrees for linkage analysis. Eur J Hum Genet

:

–

Lunetta KL, D’Agostino RB Sr, Karasik D, Benjamin EJ, Guo CY, Govindaraju R, Kiel DP, Kelly-Hayes M, Massaro JM, Pencina MJ, Seshadri S, Murabito JM (

) Genetic correlates of longevity and selected age-related pheno- types: a genome-wide association study in the Framingham study. BMC Med Genet

(Suppl

):S

Matise TC, Chen F, Chen W, De La Vega FM, Hansen M, He C, Hyland FC, Kennedy GC, Kong X, Murray SS, Ziegle JS, Stewart WC, Buyske S (

) A second-generation com- bined linkage physical map of the human genome. Genome Res

:

–

M