References:

Akisaka, M., Suzuki, M., Okinawa Longevity Study. Molecular genetic analysis of HLA genes in the very old. Nippon Ronen Igakkai Zasshi, Amadori, A., Zamarchi, R., De Silvestro, G., Forza, G., Cavatton, G., Danieli, G.A., Clementi, M., Chiecobianchi, L., Genetic control of the CD/CD T-cell ratio in humans. Nat. Med., Awad, M.R., El-Gamel, A., Simm, E., Hasleton, P., Yonan, N., Deiraniya, A.K., Sinnott, P.J., Hutchinson, I.V., Genotype variations in the transforming growth factor-beta gene: an association with TGF-b production, fibrotic lung disease and graft fibrosis after lung transplantation. Transplantation(), Azuma, M., Cayabyab, M., Philips, J.H., Lanier, L.L., Requirements for CD-dependent T cell-mediated cytotoxicity. J. Immunol.(), Bidwell, J., Keen, L., Gallagher, G., Kimberly, R., Huizinga, T., Mermott, M.F., Oksenberg, J., Micholl, J., Pociot, F., Hardt, C., DAlfonso S. Cytokine gene polymorphism in human disease: on-line databases. Genes Immunity(), Bonafé M et al. A gender-dependent genetic predisposition to produce high levels of IL-10 is detrimental for longevity. Eur J Immunol(), Bruunsgaard H. Aging and proinflammatory cytokines. Curr Opin Hematol.(), Caruso, C., Candore, G., Romano, G., Lio, D., Bonafé M., Valensin, S., Franceschi, C., HLA, aging, and longevity: a critical reappraisal. Hum Immunol.(), Clementi, M., Forabosco, P., Amadori, A., Zamarchi, R., De Silvestro, G., Di Gianantonio, E., Chieco-Bianchi, L., Tenconi, R. CD and T lymphocyte inheritance: evidence for major autosomal genes. Hum Genet.(), E. Naumova et al. / Experimental Gerontology 39 (2004) 637644 E et al. Polymorphic haplotypes of the interleukin-10 5 flanking determine variable interleukine-10 transcription and are associated particular phenotypes of juvenile rheumatoid arthritis. Arthritis Rheumrejection. Transplantation, 

Retroviruses and disease. Rev. G., Frasca, D., Genes, immunity, and senescence: looking for a link. Immunol. Rev., 

R., Boucher, N., Porter, V., Zhu, X., Spaulding, C.C., Walford, Kronenberg, M., Cohen, D., Schachter, F.F., Decline in CD4 T cells in centenarians and in long-term T cell cultures: a possible role for both in vivo and in vitro immunosenescence. Exp. Gerontol., 

W.B., Keller, E.T., Age-associated increase in gene expression, late-life diseases, and frailty. Annu. Rev. Med., 

F.F., Vescovini, R., Mazzola, M., Bologna, G., Nigro, Lavagetto, G., Franceschi, C., Passeri, M., Sansoni, P., of cytotoxic CD4+ CD8- T cells in healthy aging people and centenarians. Immunology ( ), 

F.G., Immune parameters in a longitudinal study of an old population of Swedish people: a comparison between survivors and non-survivors. J. Gerontol. A ( ), 

B.D., Faulds, G., Jeffery, R., Mohamed-Ali, V., Yudkin, Humphries, S., Woo, P., Effect of novel polymorphisms in interleukin-1 (IL-1) gene on IL-1 transcription and plasma IL-1 and an association with System-onset juvenile chronic arthritis. J. Invest. , 

C., Bonafe, M., Valensin, S., Olivieri, F., De Luca, Ottaviani, E., De Benedictis G., Inflamm-aging: a perspective on immunosenescence. Annu. NY Acad. Sci., 

M.A., Norman, P.J., Thiel, B., Tiwari, H., Peiffer, A., Vaughan, Prescott, S., Leppert, M., Schork, N.J., Lanchbury, J.S., Quantitative trait loci on chromosomes 6, 8, 9, 14, 15, 19, 20, and 21 control variation in levels of T and B lymphocyte subpopulations. J. Hum. Genet., 

N., Bidwell, J.L., Smith, A.J.P., Keen, L.J., Gallagher, Kimberly R., Huizinga T., Mermott M.F., Oksenberg M icholl J., Pociot F., Hardt C., DAlfonso S., Gene polymorphism in human disease: online databases. Immunity (Supplement ), 

D.R., Pirskanen R., Matell G., Lefvert A.K., Tumor necrosis factor-alpha polymorphism and secretion in myasthenia gravis. J. Neuroimmunol., 

R., Henon N., Lepage V., Charron D., Vicaut E., Schachter HLA-DR alleles display sex-dependent effects on survival and discriminate between individual and familial longevity. Hum. Genet. , 

M., Spassova P., Michailova A., Naumova E.. Distribution of HLA class I alleles and haplotypes in Bulgarians: contribution to understanding the origin of the population. Antigens , 

M.. Rozemuller E.. Tyufekchiev N.. Michailova A.. Tilanus Naumova E.. HLA polymorphism in Bulgarians defined by high-resolution typing methods in comparison with other populations. Tissue Antigens , 

Ivanova M.. Michailova S.. Michailova A.. Nedialkova A.. Naumova E.. Molecular model for HLA class II associations in common autoimmune diseases. Genes Immunity, 

Kroeger K.M., Steer J.H., Joyce D.A., Abraham L.J., Effects of stimulus and cell type on the expression of the -308 tumor necrosis factor promoter polymorphism. Cytokine, 

Lagaay A.M., DAmaro J., Ligthart G.J., Schreuder G.M., van Rood J.J., Hijmans W., Longevity and heredity in humans: association with the human leucocyte antigen phenotype. Annu. NY Acad. Sci., 

Lio D., Scola L., Crivello A., Bonafe M., Franceschi C., Olivieri F., Colonna-Romano G., Candore G., Caruso C.. Allele frequencies of T- . A single nucleotide polymorphism at the first intron of interferon-gamma gene in a group of Italian centenarians. Exp. GerontolRejection. Transplantation, Volpato, S., Gyralink, J.M., Ferrucci, L., Balfour, J., Chaves, P., Fried, L.P., Harris, T.B. Cardiovascular disease, interleukin and the risk of mortality in older women: the Women's Health and Aging study. Circulation. 

Wikby, A., Maxson, P., Olsson, J., Johansson, B., Ferguson, F.G. Changes in CD4 and CD8 lymphocyte subsets, T-cell proliferation responses and non-survival in the very old: The Swedish longitudinal OCTO immune study. Mech. Aging Dev. 

Wikby, A., Johansson, B., Olsson, J., Lofgren, S., Nilsson, B., Ferguson, F. Expansion of peripheral blood CD8 T lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: The Swedish NONA immune study. Exp. Gerontol.