Be ENE IIETanaka « oNLet “" PStal. | <+;;:> ) reported | the 1 >mtDNA | . polymorphism ; 1 at t nucleotide | > position 1 (cid:17)(cid:3)%+,:(cid:30)  to  SON RE NE A AMEtransversion, Ppto be at  REE EE NE ™ ODsignificantly aincreased frequency ae peeswithin  sample ao?of Japanese. NE TE NALEYcentenarians | o_o er, compared  7 &*a =control | ad eeegroup | aged (cid:4)*3 Oeyears | old. ' The TEfrequency “reWas | reported | Lat | 3’= in. 4, ‘re NN eecentenarians and - *%= “br Sin| “oo.| the | ’%’ aM Iecontrol | _ samples. ' This | ene poly- ue a peemorphism, 1 (cid:17)(cid:3)%+,:(cid:14)(cid:30) , Was | ; not ¢ t observed 1 lin; 1 any of t the : - samples sof t the | > Irish | ee PT| population ( <’’;> NS OE ODexamined here but fag veewas | observed at ’(= eee dE Ee esfrequency odin “re cohort of Tee PMP| Asian pees” N\Asamples <4(> included i Jin t | this : ; study. ° . The | - Trish | | population i is ; al pie aErelatively « closed | | population eee t. and 1 eee AMM| therefore does 1 ; not « | display | the | “Je eee be- genotypical « rere| diversity ’ that j Is eee NE YN; expressed | aes PSP™| globally. ’ . This | ; polymorphism, (cid:17)(cid:3)%+,:(cid:14)(cid:30) is eelinked to ar ithe ypeAsian NINES FONhaplogroup  and “eeeresults in the ee eeabsence “yanof an eeeAlu ~— eee ENEDrestriction s » awa| site ¢ - and | | has 1 s not % tas \ yet | ee EI| been 1 oat — ees ae| reported i lint \ the | - European | | population | | (Torroni « i et i tal., +;;3>(cid:28)    is therefore | OE EEunderstandable | that   ~~Fr*polymorphism ees Peeassociated ee EE NEwith  the | ee eeeJapanese DMI EEpopulation is not found within the Irish |   CO OE EE OSexamined.   has been eek a wpepostulated that (cid:17)(cid:3)%+,:(cid:14) genotype | decelerates the | EE OID TESaccumulation | of “mtDNA mutations “ORin| somatic | cells with < “Me” oN1 advancing < Age ( > (Tanaka « Let tal., 7 ’(((>(cid:28) Iti tis { s further | r postulated t | that t t this § ; genotype i >is | 3 likely to » confer 1 NEES NEr resistance t e\a®> to os ODy adult-onset « 9 eee aet diseases | s by : 0 EE/ suppressing ¢ r obesity « rand ¢ ne Bees J PM eee| atherosclerosis. * ewe. The    frequency    "the (cid:17)(cid:3)%+,:(cid:14)     ~e Nrpolymorphism oewithin otthe | OF OEJapanese  younger  - population <*%=> “ee) may | be 1 Jeerelevant t to { ) the | oFfact t rea”| that | eeelife « Se a: expectancy i in. Me ee| Japan i | onLis ; One « cy- of t —EF the | >’ PVP- highest j tin | | the EM IMSworld ; FOSland i i1 ity t would | | be « > of i f interest t ( to i BEDELER DDE) investigate t > the { OO IEEE AEE- frequency « oo/ of t f this ] NIE INE III IIE; polymorphism 1 1 in « . other Oriental populations ; with | lower. ‘life. NE- expectancies. | ~Our wT' data | NEES_ however | irules | peesout . (a) role | for this | ee; polymorphism | | in. | successful | a ENageing | re"in | the | Irish | Caucasian | | population.

peThe 1 (cid:17)(cid:3);(%%(cid:14) . polymorphism ' 1 Was ¢ eet —; observed ¢ | at i tat . frequency « ofJ +4(cid:28)’= in t \ the | » French : | study of : ’*: EN NEE OOS} centenarians adsand ; ws| at ¢ 3(cid:28)3= in‘ 1 a i control | | group « “ad) of 7 ’:% aM SSadults ( ; (Ivanova « Let: tal., +;;:>(cid:28) In  ; study 1 ’ the | - polymorphism ' | Was ¢ ; observed t | to | oer °y have :  | frequency « a“of ! %= in t \ the « ph ED DN A- control ; aM ae| group <+(( eee DRE) samples) ; res’) and § ;= eeein | the é aged | | group | <+’; eee DS) samples). ° spe_ These | results « ; confirm 1 the | —— Esser: finding Aa™Mof 1 the | TEE- French § ONE| group ) although t “oo\ the * ~~“ Oe rvalues \  adid 1 | not ; eee eeattain | Wye A a| statistical : | significance. ’ . The : LL- sample numbers ENED IEE_ incorporated | in oothis | study. are | relatively low compared | Coeto the | sample eTnumbers used i | in 1 the | ees Bees: French : | study ; rand 1 | this 1 sz *; may | ‘relate 1 to f way”) the ; NET) apparent ¢ ree RN| discrepancy | OT ES‘ between 1 the 1 two studies. ' _ These results | _—; would : BENE IIIS| suggest 1 ‘J omethat ( the | Me™ SP pee- polymorphic 1 se eee poenucleotide | <(cid:14)> ) at 1 (cid:17)(cid:3);(%% may be ; - associated | | with | | successful ; es ooée’ *| ageing but | 1S | wo pMnot ; wd Jon ee| major | factor | in| . the ; we ay ee *ageing | ; process, | and would 1 | therefore 1 not | be ¢  | good | “oem| predictive 1 - marker | for : “ee eee‘successful ; DAE REE EES| ageing. | It: am Pee| should | | be 1 mor: noted that no strong | se EE &*correlation —_—between this polymorphism and | meee SEEany | of | the. groups | of ‘related haplotypes « MeN NN EEE; displaying { : frequency ¢ NE IIE EDdifferences | odo pees; between t \ the t » two ¢ age | EE OE» grOUPS | > WaS ¢ “Pre Meso; observed. ( . Of the +, ypeemeerespositive JONESsamples for et” Matethis polymorphism, +’ a es SON SD(containing all rPeomsfive control cases) Mee REoccurred | ins Grp. 4 mee”(all | hap2), meeefour pedin| JooGrp - * De DOOD(three vwwith | | hap32 | “Eeand | one with | (cid:6)(cid:10)(cid:15)4*> and one | in |   , <(cid:6)(cid:10)(cid:15)’,>(cid:28)