+, . Tan ¢ 1 et ¢ tal. / - / Experimental ( | Gerontology - ./ 012234 3.2.53.36

Table | / | (continued)

Genotypes Control  | group Centenarian | 1 group (cid:1)- > (p-value) — &number ( © ONEr (frequency) number ( ee PITr (frequency) 363 7/8.(cid:30)-1: DE8.(cid:30)-J: aiAngiotens | "6(cid:26)-,7 .(cid:30)7,8.(cid:30)JJ: "" F/8.(cid:30)D/: JJ8.(cid:30),J: "(cid:26) EF8.(cid:30)DE: F78.(cid:30)D/:  -/8.(cid:30)//: -,8.(cid:30)//:

related | | not | only 1 to yan | | increased | “Pe| risk | of | atherosclerotic « vie Spee bP Pee- cardiovascular | wane It Eeedisease   | Finnish (Kervinen « et: aetal., /EED: ) and | | Danish ( | (Gerdes « set % tal., ‘ -...(cid:2): ) studies | » but : also | to f ) the j - incidence eeof | ’ Alzheimer’s « eg RA ANE; disease | : (Corder « “et i tal., /EE,:(cid:30) oo on_ Further 1 ee pes‘more, | , homozygosity « of f * the « (cid:15)D allele has | been confirmed |   een| show | eeedeleterious eo per”effect | On | EE EEN DE OYEmortality | at  old | | ages | sO ~_(Heijmans |  et.   -...: ) and ; bas | Significant « - depletion | of 1 * the | (cid:2)D allele | has | ee; been | ere| found : ce NSin | “owe es| French | OE OD SOS| (Schachter | ee“et al., /EED:(cid:27) “oe, Finnish ( OLE EE1 (Louhija « Let é tal., /EED:(cid:27) . Danish ( | (Gerdes set tal., : -...(cid:19):(cid:27) ENED NEEChinese ( - (Zhang « ret al., /EEF: and | ENE NII OOOJapanese ee OD(Asada et al., /EE1: me eee eecentenarians. —_— orOther NID AADgenes that ewehave mo”been MO y AA ASstudied cers| for | NE Ne NES‘ polymorphisms ; ————™ eee; associated | | with | *(cid:1)3 and | | longevity | eeeinclude | genes | ; coding | for ENE EE IIEapolipoprotein | # ee Oe| (Hegele « et < tal., | /EF10 ; Myant tet ¢ tal., | /EFE0 oN rey oe; Paulweber « ret é = &*tal., | /EE.0 ~~ N; Kervinen “rTet oneal., /EED0 3(cid:15) Fae SomeBenedictis, /EEJ(cid:27) /EEF:(cid:27) vee ee REN A AMADAapolipoprotein A-I (Hoeg, /EE10 owen”Saha | et | al., /EE7:(cid:27) NESS, apolipoprotein | /C-1 wey AA AED”(Galinsky aeet 3 aMcal., /EEJ:(cid:27) ween EE_ angiotensin « 6 ALE EMN OOD ES| converting | aNenzyme | 8(cid:28)*!: fA eI(Galinsky eeeet i rYr**-al., /EEJ0 — A AeNakata | et cal., /EEJ0 EE ONAlvarez | et: cal., /EEE0 EERE EES SO”Schachter | et. cal., /EED:(cid:27) EN FN OODangiotensinogen | an| (Cong «  tal., /EEF0 aeg naw; Chen ¢ of9 4let tal., /EEF0 me Re A A Ae; Frossard « “eolet i tal., | /EEF:(cid:27) and t “aeo =I the DA AEDtissue EE III AEplasminogen « ore Me| activator | 8(cid:26)&(cid:28): 8"(cid:2)(cid:10)%(cid:6) yet tal., /EEE0 CODE AO; Thogersen « et ¢ tal., /EEF:(cid:30) ee N. Sex-dependent reeeffects ne: on | *(cid:1)3 eee RAE) prevalence : CAP MAN>and : | survival ' 2 ae| were | i rr —: reported i oein: | some ¢ of | eg hawthese : Pees: studies | “Pee; (Galinsky et al., /EEJ0 3(cid:15) Benedictis et al., /EEF:(cid:27) oN aM pMwhich suggests that the wee Oepenetrance of eeeloci RO A A AEinfluencing | *(cid:1)3 )and | survival 1 eee| may) 9 *a"”vary 3 NT NN BESaccording | to: ‘oof) Sex.’ To detect | ~ pee”how | the - CVD-asso- ciated i — aegenetic variations  LEIA TONSrelated “dDto eelongevity >in the Danish population, one study “ee &*focused SNeeson | polymorphisms | of | genes - NN ENE, involved | in | eisregulating | CEE” ESblood» Pree| pressure | weeny MSand | | in _ blood TNE IEEcoagulation ree’wy”| Was ¢ ee OO I; conducted | OE| (Bladbjerg « et 3 cal., /EEE:(cid:30) oe Se_ However, | no: ue pee eRsignificant : | associations ~“—so™were I : reported lint \ the : » study, — eer, which 1 oN IED1 used « > Nh RD NA A AO| conventional : awed| statistical ¢ oan oooee| analysis, 1 , namely, t , the § : gene- ua aN peefrequency - method | oN ee DD| (Table /:(cid:30) In| | this | paper, 2(cid:15) apply al | NEW | EE OSI JOOS- approach | OD| derived | Jom| by | a oe- Vaupel ataand ie| Yashin ‘   . and «  ~~| developed i ~ Fe| in: IE| several 1 rere)?| recent — ~ RE’-t articles | ; (Yashin ¢ | et oe ietal., /EEF(cid:27) /EEE(cid:27) -...0 -Tan et al., -../: on the tebe ae eepreviously published data ae eee(Bladbjerg et al., /EEE:(cid:27) aoeand emscombine both op NE MEERdemographic r*and EEE TDindividual genetic ee eSinformation _—seto a idetermine “erthe relative risks of ‘the | EIS Ee AEEobserved | | genetic variations. | +(cid:15) - incorporate | important : factors | such ; | as | ; sex-depen- dent NNinfluences ooueNeand also individual EEN DE EE OEheterogeneity in unobserved frailty, ——————which was  previously | ignored. ’  | this : strategy, 2(cid:15) Can | ee EI| detect | - polymorphisms |  that : | show ] potential Pew eee 2sex-dependent ¢ effects. | +(cid:15) COE NEI ES J- estimated | mye t*| the 1 relative 1 oe Tisks | of 1 “soe‘the « ee ee ee- observed | | genes > aS "pees; well : Las ¢ of eee peesgene—sex i interaction < 1 and | | present [ sex-specific s - survival z | and t | the ¢ Nee"> estimated | = hi| proportions « sof t f the

 _ Materials : ; and | | methods

1,3, Individual , | genotype « data