, Results

The 1 - results « of | f parameter ¢ r estimates > are § > shown i .in | Table ‘ -(cid:30) . The » significance | levels 1 s for risk parameters | eee pee(relative | risks - for | the | genes |  and  | for | " gene—sex | ee EOinteraction) | ) are | - determined |    ree eeetesting 1 the : veyeeseee ve A> statistical « | differences | oe: between 1 | the « aN Ge- estimated 1 | risks ; sand « | one ' anf SAN- with | null | LE DID| hypothesis $   “oO  /(cid:30) . The j p-values s for | r frequency | / parameters > are - obtained | | by 1 testing | $    ‘2  .(cid:30) . The . . SEQ 8 BOhighest | RENt likelihood \ | was eee EDs achieved \ “pee| when } (cid:4)- Ds1S s about ( .(cid:30)D(cid:30) _ There i is 1 Mesno § PD ENO) significant 1 )*t risk { : for « reach TSof | ol“the : - single | gene allele, ' which | Lis | ; consistent ' with | | Bladbjerg « et i tal. | 8/EEE:(cid:30) _ However, | three INE OID OEpolymorphic Oovariations, angiotensinogen "6(cid:26)-,7(cid:27) eee dEFVII (6(cid:25),7,(cid:27) aaa yeand FVII-323ins10, reeseisplay eesignificant eID BODE OEsex-dependent ESeffects that awereduce the rN oShazards of death for male aepes sycarriers coof ee ONangiotensinogen "-,7(cid:27) FVII (cid:25),7,(cid:27) and 9(cid:1)(cid:29)(cid:29)5,-,&/. by factors of

+, _ Tan ¢ 1 et ¢ tal. / - / Experimental ( | Gerontology - ./ 012234 3.2.53.36

Table : -

Parameter ¢ r estimates { : for t r the ¢ *(cid:1)3 ) associated § | genes \ s with | 1 heterogeneity

Gene «  > allele Frequency ((cid:4)(cid:8)% ((cid:4)(cid:8)%  f gene—sex i : interaction Est. p-value Est. p-value "(cid:26)=9((cid:20)(cid:28) .(cid:30)E/ /(cid:30)/7 .(cid:30)DD .(cid:30)FD .(cid:30)DD "(cid:26)=9((cid:20)(cid:1) .(cid:30)7- .(cid:30)EE .(cid:30)E/ .(cid:30)E7 .(cid:30)J7 Angiotens-M .(cid:30)7E /(cid:30)/- .(cid:30),. .(cid:30)1J .(cid:30)..  CN NENAngiotens-T .(cid:30)FE /(cid:30)/. .(cid:30)7E .(cid:30)E/ .(cid:30)1E et — enedACE-I .(cid:30)J7 /(cid:30).7 .(cid:30)J. .(cid:30)E- .(cid:30)1, (cid:28)*!(cid:20)3 .(cid:30)JJ .(cid:30)E7 .(cid:30)1J /(cid:30)/, .(cid:30)7- 9(cid:1)(cid:29)(cid:29)(,7, .(cid:30)EE .(cid:30)F1 .(cid:30)JJ /(cid:30)17 .(cid:30)7D 9(cid:1)(cid:29)(cid:29)(cid:25),7, .(cid:30)-. /(cid:30)-7 .(cid:30)/1 .(cid:30)1F .(cid:30)./ 6atPA-I .(cid:30)F7 /(cid:30)/7 .(cid:30),D .(cid:30)EE .(cid:30)EF t-PA-D .(cid:30)1, /(cid:30).D .(cid:30)J. .(cid:30)E, .(cid:30)1- &(cid:28)(cid:29)(cid:20)1J7(cid:20)D@ .(cid:30)F. /(cid:30)/1 .(cid:30)-J .(cid:30)E1 .(cid:30)F, &(cid:28)(cid:29)(cid:20)1J7(cid:20)7@ .(cid:30)J, /(cid:30).- .(cid:30)FF /(cid:30).D .(cid:30)F/ GPIIbIMa-L .(cid:30)EF /(cid:30)/E .(cid:30)1, .(cid:30)FE .(cid:30)JE GPIIbIIa-P .(cid:30)-E /(cid:30).- .(cid:30)F7 .(cid:30)E1 .(cid:30)JJ 9(cid:1)(cid:29)(cid:29)(cid:20),-,&. .(cid:30)EE .(cid:30)EE .(cid:30)EJ /(cid:30)-/ .(cid:30)J7 9(cid:1)(cid:29)(cid:29)(cid:20),-,&/. .(cid:30)-- /(cid:30)-1 .(cid:30)/, .(cid:30)1E .(cid:30)./ FVIlintron7-H6 .(cid:30)E. /(cid:30)/. .(cid:30)1. /(cid:30)/7 .(cid:30)77 FVIlintron7-H7 .(cid:30)DJ .(cid:30)EE .(cid:30)EE .(cid:30)F7 .(cid:30)-D Fibrinogen-G .(cid:30)EF .(cid:30)EE .(cid:30)EF .(cid:30)-- .(cid:30),, EE EEEFibrinogen-A. .(cid:30),D /(cid:30)/1 .(cid:30)-- .(cid:30)F/ .(cid:30)/D

eee OMfemales is set to one | as Mw aN Peereference. TDThe > see-*result indicates that some   polymorphisms that reduce the hazard of *(cid:1)3  also favourable for male ~~ oe PM,longevity edbut peesnot for female longevity. In Fig. /(cid:27) sex-specific survivals for carriers and ON Ney eeenon-carriers of the IOI IIE II EESangiotensinogen "-,7 Se teallele are Creeplotted. The male carriers have better survival than II IERnon-carriers but for females it is the opposite although the difference in survival between female carriers and REE TEnon-carriers rr’is very eesmall. “OooThe observed and estimated proportions of carriers of the angiotensinogen " allele by age for males and for rerefemales are plotted in Fig. -(cid:30) eM meWhile the oe Aefrequency of ao MF USScarriers >~of the M-allele goes up with age renin males, it ‘omtends to decline in peefemales due to the sex-dependent ou“influ- ence of the gene.

frequencies | for | carriers ( — |of 1 res‘the | gene i meealleles. ° _ The —e ee: p-values | reserfor | * the « - estimated | | initial | | frequen- cies  not shown since a =they are all IIE FOREsignificantly different from Zero. eis ttietProportions of carriers | of 1 the 1 three alleles. , are | PN OEE AE- estimated | ‘on| as | .(cid:30)7E/(cid:27) .(cid:30)/E7 and | .(cid:30)--. ne EE ee) respectively.

 _ Discussions

Incorporation \ of § F gene—sex i interaction in 1 \ the - analysis | ; produces 1 s results 1 ; that | [ were 1 : missed

1.0 0.9 0.8 0.7 (+), male 0.6 (-), male (+), female 0.5 (-), female 0.4 0.3 0.2 0.1 0.0 20 30 40 50 60 70 80 90 100 age lavivruS

Fig. | /(cid:30) . The s > sex-specific s > survivals f s for « r angiotensinogen } " [ allele « > carriers sand 1 | non-carriers.