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The present study aimed to investigate the potential role that KIR diversity may play in immunosenescence and longevity within the Irish population. However, no significant association between successful ageing and KIR gene content was observed. A number of reasons could help explain this lack of association; sample numbers are always a concern when examining regions of extreme genetic diversity and the use of two independent aged sampling cohorts was employed to try and minimize any false-positive findings of association. In the context of the present study (L.D. Maxwell et al. / Experimental Gerontology 39 (2004) 1223-1232), Lio, D., Scola, L., Crivello, A., Colonna-Romano, G., Candore, G., Bonafe, M., Cavallone, L., Franceschi, C., Caruso, C. "Gender-specific association between IL-6 promoter polymorphism and longevity." Genes Immun., Ljunggren, H.G., Karre, K. "In search of the missing self: MHC molecules and NK cell recognition." Immunol. Today, Malaguarnera, L., Ferlito, L., Imbesi, R.M., Gulizia, G.S., Di Mauro, S., Maugeri, D., Malaguarnera, M., Messina, A. "Immunosenescence: a review." Arch. Gerontol. Geriatr.,
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Ljunggren H.G., Karre K. In search of the missing self: MHC molecules and NK cell recognition. Immunol. Today,
Malaguarnera L., Ferlito L., Imbesi R.M., Gulizia G.S., Di Mauro S., Maugeri D.,
Malaguarnera M., Messina A. Immunosenescence: a review. Arch. Gerontol. Geriatr.,
Malnati, M.S., Lusso, P., Ciccone, C., Moretta, A., Moretta, L., Long, E.O. Recognition of virus-infected cells by natural killer cell clones is controlled by polymorphic target cell elements. J. Exp. Med.,
Marsh S.G.E., Parham P., Dupont B., Geraghty D.E., Trowsdale J., Middleton D., Vilches C., Carrington M., Witt C., Guethlein L.A. Shilling H., Garcia C.A., Hsu K.C., Wain H. Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, Hum. Immunol.,
Merlan S.E., Rea I.M., Alexander H.D., Morris T.C. Changes in natural killer cells, the CD CD subset, and related cytokines in healthy aging. J. Clin. Immunol. (),
Martin A.M., Freitas E.M., Witt C.S., Christianssen S.T. The genomic organization and evolution of the natural killer immunoglobulin-like receptor (KIR) gene cluster. Immunogenetics,
Meyaard L., Adema G.J., Chang C., Woolatt E., Sutherland G.R., Lanier L.L.,