Table 3. Frequency of Minor Allele of Each Tagging SNP of RPToR on Chromosome 17p25.3 in Long-Lived Case vs Control Participants

Total Number of Minor Allele Frequency of SNP ID Position Cases and Controls Cases and Controls, % (95% CI) χ2 p Value rs4889856 78513632 436/366 33.3 and 34.8 (–0.062 to 0.031) 3.70 .16 rs8064502 78562434 440/374 36.4 and 31.7 (0.001 to 0.093) 4.01 .14 rs4890052 78564245 438/371 34.0 and 36.4 (–0.070 to 0.023) 2.68 .26 rs7220588 78598231 437/371 34.3 and 37.1 (–0.074 to 0.019) 2.91 .23 rs901065 78599655 425/360 35.3 and 31.9 (–0.013 to 0.080) 2.89 .24 rs8066867 78620072 430/360 27.3 and 29.0 (–0.062 to 0.027) 1.61 .45 rs4889782 78640510 440/374 30.1 and 32.1 (–0.065 to 0.025) 1.73 .42 rs4889875 78651500 440/374 34.8 and 37.0 (–0.069 to 0.024) 1.29 .53 rs8065598 78678243 438/371 31.4 and 32.6 (–0.058 to 0.033) 0.30 .86 rs4969256 78745643 440/374 52.3 and 49.1 (–0.017 to 0.081) 2.68 .26 rs9898212 78751489 440/374 28.6 and 29.1 (–0.049 to 0.039) 0.89 .64 rs11150745 78757626 440/374 34.9 and 31.1 (–0.008 to 0.083) 2.72 .26 rs11150746 78761389 440/374 28.6 and 29.1 (–0.049 to 0.039) 0.08 .96 rs4969266 78761546 440/374 47.0 and 47.2 (–0.050 to 0.047) 0.51 .77 rs11150747 78761607 439/373 19.0 and 19.5 (–0.043 to 0.034) 0.23 .89 rs4969426 78762808 440/374 20.6 and 23.8 (–0.073 to 0.008) 4.34 .11 rs8069962 78766464 440/374 25.6 and 29.0 (–0.078 to 0.009) 2.44 .30 rs12601434 78767275 438/372 31.4 and 28.2 (–0.013 to 0.076) 1.93 .38 rs11654508 78771947 410/353 35.5 and 32.1 (–0.014 to 0.081) 2.38 .30 rs7225574 78777941 440/374 13.1 and 16.0 (–0.064 to 0.005) 5.13 .03 rs2672886 78781651 426/362 49.8 and 49.7 (–0.049 to 0.050) 0.58 .75 rs734338 78782340 440/374 46.4 and 46.5 (–0.050 to 0.046) 1.86 .51 rs7212127 78787662 440/374 11.5 and 11.4 (–0.030 to 0.032) 0.01 .99 rs2589134 78793593 438/374 34.6 and 34.0 (–0.040 to 0.053) 0.45 .80 rs2672901 78796666 440/373 29.3 and 32.0 (–0.072 to 0.018) 4.97 .08 rs2589143 78810687 437/371 49.7 and 44.7 (–0.000 to 0.098) 6.69 .04 rs2589157 78820023 440/374 30.2 and 28.5 (–0.027 to 0.062) 0.71 .70 rs3751945 78820329 440/374 41.3 and 43.3 (–0.069 to 0.027) 2.41 .30 rs2333988 78821447 439/374 18.9 and 16.2 (–0.011 to 0.063) 2.90 .23 rs2672893 78827863 440/374 39.0 and 36.7 (–0.025 to 0.069) 0.34 .84 rs4969282 78828266 440/377 28.4 and 26.2 (–0.022 to 0.065) 1.00 .61 rs9895380 78829484 440/374 10.2 and 10.4 (–0.032 to 0.028) 1.49 .47 rs2672890 78834207 440/374 36.6 and 39.2 (–0.073 to 0.021) 1.29 .52 rs2589118 78836553 440/374 51.5 and 49.6 (–0.030 to 0.067) 0.66 .72 rs2063785 78836846 440/374 8.3 and 8.8 (–0.033 to 0.022) 1.59 .45 rs2589141 78843139 440/374 42.0 and 44.3 (–0.070 to 0.026) 0.83 .66 rs2289762 78859110 440/374 38.1 and 35.2 (–0.018 to 0.076) 2.21 .33 rs11656061 78864749 440/374 44.7 and 40.8 (–0.009 to 0.087) 3.08 .21 rs2289763 78865491 440/374 16.4 and 17.2 (–0.045 to 0.028) 3.33 .31 rs7217623 78873014 440/374 22.4 and 22.1 (–0.037 to 0.044) 4.03 .13 rs2280146 78875669 440/374 22.8 and 23.5 (–0.048 to 0.034) 2.75 .25 rs868432 78877735 440/374 48.3 and 48.5 (–0.051 to 0.046) 0.52 .77 rs4969301 78885904 440/374 25.5 and 27.5 (–0.064 to 0.022) 1.23 .54 rs12938300 78894022 439/374 49.4 and 45.3 (–0.008 to 0.090) 0.80 .67 rs908236 78898600 440/374 34.1 and 33.7 (–0.042 to 0.050) 0.29 .86

Table 3. (continued)

Total Number of Minor Allele Frequency of SNP ID Position Cases and Controls Cases and Controls, % (95% CI) χ2 p Value rs6565494 78898778 417/357 24.3 and 23.9 (–0.039 to 0.047) 0.20 .90 rs2271608 78899458 440/374 9.8 and 10.2 (–0.033 to 0.025) 0.50 .78 rs4969227 78900598 440/374 15.3 and 16.7 (–0.050 to 0.022) 0.60 .74 rs4969311 78906360 440/374 25.1 and 26.9 (–0.060 to 0.025) 1.12 .57 rs7210742 78912010 440/374 39.8 and 40.9 (–0.059 to 0.036) 0.47 .79 rs1468032 78915387 424/360 49.1 and 48.4 (–0.042 to 0.057) 0.15 .93 rs2292639 78915955 440/374 51.0 and 49.2 (–0.030 to 0.067) 0.64 .73 rs6565500 78916499 440/374 37.7 and 39.4 (–0.065 to 0.030) 1.26 .53 rs4969314 78923007 379/342 13.5 and 13.9 (–0.040 to 0.031) 1.73 .42 rs1468035 78923953 440/374 38.1 and 39.6 (–0.063 to 0.032) 0.47 .79 rs12951778 78930344 440/374 25.1 and 26.3 (–0.055 to 0.030) 0.02 .99 rs3751934 78938498 440/374 44.5 and 43.0 (–0.033 to 0.063) 0.72 .70 rs3751932 78939414 440/374 12.8 and 13.5 (–0.040 to 0.026) 1.86 .39 rs4969322 78944104 440/373 53.3 and 49.5 (–0.010 to 0.087) 2.30 .32 rs7502124 78945137 434/372 24.2 and 26.6 (–0.067 to 0.018) 1.28 .53 rs11653897 78951177 440/374 22.3 and 23.1 (–0.049 to 0.032) 0.48 .79

notes: There were 424 SNPs with minor allele frequency ≥0.10 in the region studied. Eight SNP assays failed, leaving 61 out of 69 tagSNPs. We captured 406 of 424 alleles at r2 ≥ .8, ie, we captured 96% of alleles, and mean of maximum r2 was .92 for the 61 tagSNPs. CI = confidence interval; SNP = single-nucleotide polymorphism.

Table 4. Frequency of Minor Allele of Each Tagging SNP of RicToR on Chromosome 5p13.1 in Long-Lived Case vs Control Participants

Total Number of Minor Allele Frequency of SNP ID Position Cases and Controls Cases and Controls, % (95% CI) χ2 p rs10941413 38938664 438/373 23.3 and 22.5 (–0.033 to 0.049) 0.27 .87 rs10461998 38984797 440/374 46.0 and 45.6 (–0.044 to 0.053) 0.40 .81 rs1239256 38987371 440/374 34.7 and 35.6 (–0.056 to 0.037) 5.84 .05 rs6878291 39030707 438/374 38.6 and 39.7 (–0.059 to 0.036) 4.64 .10 rs7703002 39045342 440/374 13.5 and 14.0 (–0.039 to 0.028) 0.34 .84 rs12233987 39053547 435/369 48.4 and 48.9 (–0.054 to 0.044) 0.93 .63 rs17364997 39054742 440/374 22.7 and 23.0 (–0.044 to 0.038) 2.16 .34

notes: We captured 43 of 43 alleles at r2 ≥ .8, ie, we captured 100% of alleles and mean of maximum r2 was .91 for the seven tagSNPs. CI = confidence interval; SNP = single-nucleotide polymorphism.

notes: We captured 43 of 43 alleles at r2 ≥ .8, ie, we captured 100% of alleles and mean of maximum r2 was .91 for the seven tagSNPs. CI = confidence interval;