A further point of interest concerning these centenar- ians was their relatively high total HDL cholesterol level. According to cross-sectional and follow-up stud- ies, serum total cholesterol and LDL cholesterol de- crease in the oldest age group, but a corresponding decline is less evident for HDL cholesterol.46-47 The high levels of HDL in all our centenarians support the view that high HDL cholesterol is associated with longevity and that it may exert a protective influence against

Aalto-Setala K, Viikari J, Akerblom H, Kuusela V, Kontula DNA polymorphisms of the apolipoprotein B and AI/CIII genes are associated with variations of serum low density lipoprotein cholesterol level in childhood. J Lipid Res.

;

:

-

Aalto-Setala K, Tikkanen M, Taskinen M-R, Nieminen M, Holmberg P, Kontula K. Xbal and c/g polymorphisms of the lipoprotein B gene locus are associated with serum cholesterol LDL cholesterol levels in Finland. Atherosclerosis.

Aalto-Setala K, Gylling H, Helve E, Kovanen P, Miettinen Kontula K. Genetic polymorphism of the apolipoprotein B locus influences serum LDL cholesterol level in familial lesterolemia. Hum Genet.

;

:

-

Karathanasis SK, M

herson J, Zannis VJ, Breslow JL. Linkage of human apolipoproteins A-I and C-III genes. Nature.

;

:

-

Aalto-Setala K, Kontula K, Sane T, Nieminen M, Nikkila E. DNA polymorphisms of apolipoprotein A-I/C-III and insulin genes in familial hypertriglyceridemia and coronary heart disease. Athero- sclerosis.

;

:

-

Davignon J, Bouthikier D, Nestruck AC, Sing CF. Apolipoprotein E polymorphism and atherosclerosis: insight from a study in genarians. Trans Am Clin Climatol Assoc.

;

:

-

Eggertsen G, Tegelman R, Ericsson S, Angelin B, Berglund Apolipoprotein E polymorphism in healthy Swedish population: variation of allele frequency with age and relation to serum lipid concentrations. Clin Chem.

;

:

-

Bell GI, Karam JH, Rutter WJ. Polymorphic DNA region adjacent to the

' end of the human insulin gene. Proc Nat

cad Sci

;

:

-

Gidez LI, Miller GJ, Burnstein M, Slagle S, Eder HA. Separation and quantitation of subclasses of human plasma high density proteins by a simple precipitation procedure. J Lipid Res.

;

:

-

Friedewald WT, Levy RI, Friedrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem.

;

:

-

Kontula K, Aalto-Setala K, Kuusi T, Hamalainen L, Syvanen A-C. Apolipoprotein E polymorphism determined by restriction enzyme analysis of DNA amplified by polymerase chain reaction: venient alternative to phenotyping by isoelectric focusing. Clin Chem.

;

:

-

Havekes L, De Knijeff P, Beisiegel U, Havinga J, Smit M, E. A rapid micromethod for apolipoprotein E phenotyping directly in serum. J Lipid Res.

;

:

-

Weisgraber KH, Innerarity TL, Mahley RW. Abnormal lipo- protein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site. J Biol Chem.

;

:

-

Syvanen A-C, Aalto-Setala K, Harju L, Kontula K, Soderlund H. A primer-guided nucleotide incorporation assay in the genotyping of apolipoprotein E. Genomics.

;

:

-

Syvanen A-C, Sajantila A, Lukka M Identification of individuals by analysis of biallelic DNA markers using PCR and solid-phase minisequencing. Am J Hum Genet.

;

:

-

Karathanasis SK, Zannis VI, Breslow JL. Isolation and ization of

NA clones corresponding to two different ap

-III alleles. J Lipid Res.

;

:

-

Gardner MJ, Altman DG, eds. Statistics With Confidence: Con- fidence Intervals and Statistical Guidelines. London, UK: British Medical Journal;

Nevanlinna HR. The Finnish population structure: a genetic and genealogical study. Hereditas.

;

:

-

Nieminen M, Mattila KJ, Aalto-Setala K, Kuusi T, Kontula Kauppinen-Makelin R, Ehnholm C, Jauhiainen M, Valle M, Taskinen M-R. Lipoproteins and their genetic variation in with and without angiographically verified coronary artery Arterioscler Thromb.

;

:

-

Laakso M, Kesaniemi A, Kervinen K, Jauhiainen M, Pyorala Relation of coronary heart disease and apolipoprotein E phe- notype in patients with non-insulin dependent diabetes. Br Med J.

;

:

-

Hixson JE, PDAY Research Group. Apolipoprotein E polymor- phisms affect atherosclerosis in young males. Arterioscler

;

:

-

Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science.

;

:

-

Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance Enghild J, Salvesen GS, Roses AD. Apolipoprotein E: binding to /

-amyloid and increased frequency of type

allele late-onset familial Alzheimer disease. Proc Natl Acad Sci

;

:

-

Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance Gene dose of apolipoprotein E type

allele and the risk of heimer's disease in late onset families. Science.

;

:

-

Saunders AM, Strittmatter WJ, Schmechel D, St PH, Pericak-Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper- Ma

achlan DR, Alberts MJ, et al. Association of apolipoprotein E allele e

with late-onset familial and sporadic disease. Neurology.

;

:

-

Hegele RA, Huang L-S, Herbert PN, Blum CB, Buring JE, Hen- nekens CH, Breslow JL. Apolipoprotein B-gene DNA polymor- phisms associated with myocardial infarction. N Eng

Med.

:

-

Monsalve MV, Young R, Jobsis J, Wiseman SA, Dhamu S, JT, Greenhalgh RM, Humphries SE. DNA polymorphisms of the gene for apolipoprotein B in patients with peripheral arterial disease. Atherosclerosis.

;

:

-

Myant NB, Gallagher J, Barbir M, Thompson GR, Wile D, Humphries SE. Restriction fragment polymorphisms in the apo gene in relation to coronary artery disease. Atherosclerosis.

:

-

Lehtimaki T, Moilanen T, Aalto-Setala K, Kontula K, Porkka Akerblom H, Ehnholm C, Ronnemaa T, Viikari J. Association of apolipoprotein E and B polymorphisms with serum lipids. Ann Med.

;

:

-