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JianxinLifortheircontributionsintheChineseLongitudinalHealthyLon- gevitySurveyandtheDNAsamplescollection,andwethankallinter- FengyuZhang,QiushiFengandJessicaSautter.

CompetingInterests:Theauthorshavedeclaredthatnocompetinginter- estsexist.

HumanParticipationProtection:TheResearchEthicsCommitteesof DukeUniversityandPekingUniversitygrantedapprovalfortheProtection ofHumanSubjectsforeachwaveoftheChineseLongitudinalHealthy LongevitySurvey,whichisthedatasourceofthisstudy.Thesurveyre- spondentsgaveinformedconsentbeforeparticipating.

collectionanddataanalysis,andwrotethepaper;L.C.andH.C.ana- lyzeddata;X.L.T.andH.Q.C.ledthelaboratoryworkofDNAextrac- tion and genotyping, Y.L. and Z.X. performed data and article.

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