Acknowledgments:
We thank all participants of the Leiden Longevity Study and Rotterdam Study. The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2011) under grant agreement no. 259679. This study was supported by a grant from the Innovation-Oriented Research Program on Genomics (SenterNovem IGE05007), the Centre for Medical Systems Biology, and the Netherlands Consortium for Healthy Ageing (grant 050-060-810), all in the framework of the Netherlands Genomics Initiative, Netherlands Organization for Scientific Research (NWO), and by Unilever Colworth. The generation of Blake JA, Bult CJ, Kadin JA, Richardson JE, Eppig JT. The Mouse Genome Database (MGD): premier model organism resource for mammalian genomics and genetics. Nucleic Acids Res.
Bluher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science.
Cawthon RM et al. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet.
Chapman J, Whittaker J. Analysis of multiple SNPs in a candidate gene or region. Genet Epidemiol.
Chen LS et al. Insights into colon cancer etiology via a regularized approach to gene set analysis of GWAS data. Am J Hum Genet.
Clancy DJ et al. Extension of lifespan by loss of CHICO, a Drosophila insulin receptor substrate protein. Science.
Codd V et al. Common variants near TERC are associated with mean telomere length. Nat Genet.
Collins K, Mitchell JR. Telomerase in the human organism. Oncogene.
De Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev.
Deelen J et al. Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell.
Eriksson N et al. Web-based, participant-driven studies yield novel genetic associations for common traits. PLoS Genet.
Flachsbart F et al. Association of FOXO A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci USA.
Fridley BL, Biernacka JM. Gene set analysis of SNP data: benefits, challenges, and future directions. Eur J Hum Genet.
Friedman DB, Johnson TE. A mutation in the age gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics.