+, . Tan ¢ 1 et ¢ tal. / - / Experimental ( | Gerontology - ./ 012234 3.2.53.36

show : CONE DOODstronger « effect « "aS FOn | re Ieee| plasma | pee\ FVIII | level 1 [int AOE NES| male t AMPs> than i 1 in | | female | Italians | 83(cid:4) ~~ — eee a| Castelnuovo et. al., /EEF:(cid:30) The | on ME EEplasma FVII. clotting | activity | has | been | suggested | as- 7~\*a risk marker | of cardiac | OMT?death aaa pee(Meade. et. al., /EE,:(cid:27) mene ™and | also the FVII | OE OD OESpolymorphisms -  predictive | of *(cid:1)3 in | “ese NA| Italian : yee—e—e—e——e—e =| studies | RED A A A,; (Iacoviello « “Fo §yet i tal., /EEF0 - Girelli « “a FEet é peetal., / -...:(cid:30) DEDEDE EDEN ES. However, t the | } putative relation | | between | . FVII | vera| polymorphisms « 7asand ( *(cid:1)3 ) are t ane ee eee» turned « a ees| down 1 wee”1 in « other istudies | 7 pees; (Lane « et al., /EE10 Feng | et "as tTal., -...:(cid:27) we peesand it may be. speculated that this. _ discrepancy is, | ~_at least MOOD AA Apartly, « MT REEcaused | ‘oe ™*| by | an ¢ “eo oreffect « ee| of | " gender. | In 2 VN pe’1 women, | FVII! levels ; are | ENE EEincreased | | by 1 yon’/ menopause res Joe(Scarabin | et | oeal., /EE.(cid:27) /EE1: =eand hormone | REE MAOEY A NAR EDNreplacement therapy OE ILLES(Cushman aoet. al., /EEE0 Ae ee eeMarchien 1 van | eeey aA @| Baal « ca)Let : “9ral., ‘ -...:(cid:27) and « | elderly \ 7 eee- women | have | Ee- higher | PANFVII! [levels 1 than | a| men « “aoof the   age | - (Scarabin | ~*9et. -al., /EE10 ees POINTIshikawa | et. -al., /EEJ:(cid:30) oe”Also, women —  | with « _ coronary artery | mai SENdisease heenhave higher aFVII otlevels than men 27awith ae’ fethe yee”disease (Kalaria | et. al., -...0 OE, NOIOssei-Gerning « et é tal., /EEF:(cid:30) . Perhaps s the ¢ > effect «  t of | f hormones «  sand | ™“| lifestyle 1 » factors « so? <<"; drown 1 —?| the effect | of EIDE OEgenotype ey nAon | *(cid:1)3 isk in women. Although there have we Jobeen many | studies | on disease “S ome TPMassociation, the present study reveals, for the first time, the ND ONE NEEsex-dependent association | of | ‘the | en BEE eee- polymorphisms » | with | J wee eee ®_ longevity.

Eegenetic remodulation |  of | human   span ~~P*in| other | studies”   eaegene | wees Beand  -longevity,   as oestudies | of 1 ‘the | =A(cid:28)(cid:20)3( alleles | 83(cid:6)(cid:3)(cid:2)% et cal., /EED0 joieIvanova «  et cal., /EEF:(cid:27) a —the | =A(cid:28)(cid:20)*2/(cid:27) *2J alleles | (Proust | et cal., /EF-:(cid:27) and the weg nAlarge | “naresallele | group | at | “neothe AA AMI MOtyrosine. “Ae nehydroxylase 8(cid:26)=L: awelocus | 83(cid:15) ee ND A A: Benedictis | et. ty &Mval., | -...0 ~~ EeeTan « SY ™et val., | -../:(cid:30) res”The : ON DO IE- sex-dependent | NEE JOONinfluence vena Fenindicates | “eXthat “Methe | effect. of |  eogene | —_on | a “aa Ne ey memultifactorial | NE Petrait depends | oTon | eeethe | physiological scenario y changes 1 in 3 | males % “Ss S&Ssand | see eee| females « differently, 1 the « effect « “~r™t of 3 a ( | certain | Me Re| gene « wy>on § oes| survival could | | vary | REE TEEbetween | | the : Sexes. | The « existence | of | Po EN" gene—sex | interaction : “es ON| Shows | not | only | the ee EE YO”complexity of the aging process. It also ~—— eeindicates that the two sexes follow ~ eee yeedifferent NET EStrajectories | , toward « Som F*| extreme | longevity | (Franceschi « et 3 cal., ‘ -...:(cid:30)