,

–

Caruso, C., Candore, G., Romano, G., Lio, D., Bonafe, M., Valensin, S., Franceschi, C.,

HLA, aging, and longevity: a critical reappraisal. Hum. Immunol.

,

–

Clementi, M., Forabosco, P., Amadori, A., Zamarchi, R., De Silvestro, G., Di Gianantonio, E., Chieco-Bianchi, L., Tenconi, R.,

CD

and

E. Naumova et al. / Experimental Gerontology 39 (2004) 637–644

CD

T lymphocyte inheritance: evidence for major autosomal genes. Hum. Genet.

,

–

E., Kay, R., Sillibourne, J., Patel, P., Hutchinson, I., Woo,

Polymorphic haplotypes of the interleukin-

flanking determine variable interleukine-

transcription and are associated particular phenotypes of juvenile rheumatoid arthritis. Arthritis

,

–

R., Leelayuwat, C., Guadieri, S., Tay, G., Hui, J., Cattley, Martinez, P., Kulski, J.,

Genomics of the major complex: haplotypes, duplications, retroviruses and disease. Rev.

,

G., Frasca, D.,

Genes, immunity, and senescence: looking for link. Immunol. Rev.

,

–

R., Boucher, N., Porter, V., Zhu, X., Spaulding, C.C., Walford, Kronenberg, M., Cohen, D., Schachter, F.F.,

Decline in CD

þ T cells in centenarians and in long term T cell cultures: a possible for both in vivo and in vitro immunosenescence. Exp. Gerontol.

, W.B., Keller, E.T.,

Age-associated increase of gene expression, late-life diseases, and frailty. Annu. Rev. Med.

–

F.F., Vescovini, R., Mazzola, M., Bologna, G., Nigro, Lavagetto, G., Franceschi, C., Passeri, M., Sansoni, P.,

of cytotoxic CD

þ CD

- T cells in healthy aging people, centenarians. Immunology

(

),

–

F.G.,

Immune parameters in a longitudinal study in a old population of Swedish people: a comparison between survivors non-survivors. J. Gerontol.

A (

), B

–B

D., Faulds, G., Jeffery, R., Mohamed-Ali, V., Yudkin, Humphires, S., Woo, P.,

Effect of novel polymorphisms in interleukin-

(IL-

) gene on IL-

transcription and plasma IL-

and an association with System-onset juvenile chronic arthritis. J. Invest.

,

–

C., Bonafe, M., Valensin, S., Olivieri, F., De Luca, Ottaviani, E., De Benedictis, G.,

Inflamm-aging. An perspective on immunosenescence. Annu. NY Acad. Sci.

–

M.A., Norman, P.J., Thiel, B., Tiwari, H., Peiffer, A., Vaughan, Prescott, S., Leppert, M., Schork, N.J., Lanchbury, J.S., Quantitative trait loci on chromosomes

,

,

,

,

,

,

,

, and control variation in levels of T and B lymphocyte subpopulations. J. Hum. Genet.

,

–

N., Bidwell, J.L., Smith, A.J.P., Keen, L.J., Gallagher, Kimberly, R., Huizinga, T., M

ermott, M.F., Oksenberg, M

icholl, J., Pociot, F., Hardt, C., D’Alfonso, S.,

gene polymorphism in human disease: on-line databases. Immunity

(Supplement

),

–

D.R., Pirskanen, R., Matell, G., Lefvert, A.K.,

necrosis factor-alpha polymorphism and secretion in myasthenia J. Neuroimmunol.

,

–

R., He´non, N., Lepage, V., Charron, D., Vicaut, E., Scha¨chter,

HLA-DR alleles display sex-dependent effects on survival discriminate between individual and familial longevity. Hum. Genet.

,

–

M., Spassova, P., Michailova, A., Naumova, E., Distribution of HLA class I alleles and haplotypes in contribution to understanding the origin of the population. Antigens

,

–

M., Rozemuller, E., Tyufekchiev, N., Michailova, A., Tilanus, Naumova, E.,

HLA polymorphism in Bulgarians defined high-resolution typing methods in comparison with other Tissue Antigens

,

–

Ivanova, M., Michailova, S., Michailova, A., Nedialkova, A., Naumova, E.,

Moecular model for HLA class II associations in common autoimmune diseases. Genes Immunity

,

Kroeger, K.M., Steer, J.H., Joyce, D.A., Abraham, L.J.,

Effects of stimulus and cell type on the expression of the -

tumor necrosis factor promoter polymorphism. Cytokine

,

–

Lagaay, A.M., D’Amaro, J., Ligthart, G.J., Schreuder, G.M., van Rood, J.J., Hijmans,W.,

Longevityand heredityinhumans.Associationwith the human leucocyte antigen phenotype. Annu. NY Acad. Sci.

,

Lio, D., Scola, L., Crivello, A., Bonafe, M., Franceschi, C., Olivieri, F., Colonna-Romano, G., Candore, G., Caruso, C.,

a. Allele frequencies of þ

T- . A single nucleotide polymorphism at the first intron of interferon-gamma gene in a group of Italian centenarians. Exp. Gerontol.

,

–

Lio, D., Scola, L., Crivello, A., Colonna-Romano, G., Candore, G., Bonafe, M., Cavallone, L., Franceschi, C., Caruso, C.,

b. Gender-specific association between

IL-

promoter polymorphism and long- evity. Genes Immunity

,

–

Maurer, M., Kruse, N., Giess, R., Toyka, K.V., Rieckmann, P.,

Genetic variation at position

of interleukin

(IL

) promotor and the outcome of multiple sclerosis. J. Neuroimmunol.

,

–

Miller, S.A., Dykes, D., Polesky, H.F.,

A simple sating-out procedure for extracting DNA form human nucleated cells. Nucl. Acids Res.

,

Modica, M.A., Cammarata, G., Caruso, C.,

HLA-B

, DR

phenotype and lymphocyte responses to phytohaemagglutinin. J. Immunogenet.

,

–

Nociari, M.M., Telford, W., Russo, C.,

Postthymic development of CD

-CD

þ T cell subsets: age-associated expansion and shift from memory to naive phenotype. J. Immunol.

,

–

Olsson, J., Wikby, A., Johansson, B., Lofgren, S., Nilsson, B.-O., Ferguson, F.G.,

Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech. Ageing Dev.

,

–

Pawelec, G., Adibzadeh, M., Solana, R., Beckman, I.,

The T cell in the aging individual. Mech. Ageing Dev.

,

Proust, J., Moulias, R., Fumeron, F., Bekkhoucha, F., Busson, M., Schmid, M., Hors, J.,

HLA and longevity. Tissue Antigens

,

Rea, I.M., Middleton, D.,

Is the phenotyping combination A

B

Cw

DR

a marker for male longevity? J. Am. Geriatr. Soc.

,

Shneider, S., Kueffer, J.M., Roessli, D., Excoffier, L.,

Arlequin: A Software Environment for the Analysis of Population Genetics Data. Genetics and Biometry Lab, Geneva. Slatkin, M., Excoffier, L.,