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Cancer is a disease that rises exponentially with age, and as the populations of many countries age, so cancer- related deaths are likely to become even more prevalent in the twenty-first century. However, centenarians have escaped overt cancer. Our data suggest that maintaining genomic stability contributes to longevity, and that DNA repair has a critical role during the aging process.

Acknowledgements This work was supported by grants from the Korean Research Foundation for Health Science, from the National Research Laboratory Programme for Rheumatic Disease, and from the Aging and Apoptosis Research Center of KOSEF, Korea Ministry of Science and Technology.