deacetylase. Science

;

:

–

Kuro-o M. Klotho and aging. Biochim Biophys Acta

;

:

–

Canto C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J. AMPK regulates energy expenditure by modulating NADþ metabolism and SIRT

activity. Nature

;

:

–

Xu X, Jhun BS, Ha CH, Jin ZG. Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activa- tion. Endocrinology

;

:

–

Jones SP, Girod WG, Palazzo AJ, Granger DN, Grisham MB, Jourd’Heuil D, Huang PL, Lefer DJ. Myocardial ischemia- reperfusion injury is exacerbated in absence of endothelial cell nitric oxide synthase. Am J Physiol

;

(

Pt

):H

–H

Flachsbart F, Croucher PJ, Nikolaus S, Hampe J, Cordes C, Schreiber S, Nebel A. Sirtuin

(SIRT

) sequence variation is not associated with exceptional human longevity. Exp Ger- ontol

;

:

–

Lescai F, Blanche H, Nebel A, Beekman M, Sahbatou M, Flachsbart F, Slagboom E, Schreiber S, Sorbi S, Passarino G, Franceschi C. Human longevity and

p

: A study in

centenarians. Eur J Hum Genet

;

:

–

L

,L

, Gupt

K,Mohle

J,Anderson ME,Grumbach IM. Calmodulin kinase II is required for angiotensin II-mediated

E-mail: puca@longevita.org; annibale.puca@multimedica.it