,

–

Haan, M.N., Shemanski, J., Jagust, W.J., Manolio, T.A., Kuller, L.,

The role of APOE in modulating effects of other risk factors for cognitive decline in elderly persons. J. Am. Assoc.

,

–

Hallman, D.M., Boerwinkle, E., Saha, N., Sandholzer, C., Menzel, H.J., Csazar, A., Utermann,

The apolipoprotein E polymorphism: a comparison of allele frequencies and effects in populations. Am. J. Hum. Genet.

,

–

Henderson, S.A., Easteal, S., Jorm, A.F., Mackinnon, A.J., Korten, A.L., El Christensen, H., Croft, Jacomb, P.A.,

Apoprotein E allele E

, dementia and cognitive decline in a population Lancet

,

–

Jian-Gang, Z., Yong-Xing, M., Chuan-Fu, W., Pei-Fang, L., Song-Bai, Z., Nui-Fan, G., Guo-Yin, Lin, H.,

Apolipoprotein E and longevity among Han Chinese population. Mech. Ageing

,

–

Kervinen, K., Savolainen, M.J., Salokannel, J., Hynninen, A., Heikkinen, J., Ehnholm, C., M.J., Kesaniemi, Y.A.,

Apolipoprotein E and B polymorphism-longevity factors assessed nonagenarians. Atherosclerosis

,

–

Ligthart, G.L., Corberand, K.X., Fournier, C., Galanaud, P., Hijmans, W., Kennes, B.,

sion criteria for immunogerontological studies in man: the Senieur protocol. Mech. Ageing Dev.

–

Louhija, J., Miettinen, H.E., Kontula, K., Tikkanen, M.J., Miettinen, T.A., Tilvas, R.S.,

and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E

phenotype Centenarians. Arterioscl. Thromb.

,

–

References

Alafuzoff, I., Helisalmi, S., Mannermaa, A., Soininen, H., 2000. Severity of cardiovascular disease, apolipoprotein E genotype, and brain pathology in ageing and dementia. Ann. NY Acad. Sci. 903,

Haan, M.N., Shemanski, J., Jagust, W.J., Manolio, T.A., Kuller, L., 1999. The role of APOE epsilon4 in modulating effects of other risk factors for cognitive decline in elderly persons. J. Am. Med.

Z., Yong-Xing, M., Chuan-Fu, W., Pei-Fang, L., Song-Bai, Z., Nui-Fan, G., Guo-Yin, F., Lin, H., 1998. Apolipoprotein E and longevity among Han Chinese population. Mech. Ageing Dev.

Menzel, H.J., Utterman, G.,

Apolipoprotein E phenotyping from serum by Western Electrophoresis

,

–

Nassar, B.A., Dunn, J., Title, L.M., O’Neill, B.J., Kirkland, S.A., Zayed, E., Bata, I.R., Cantrill, Johnson, J., Dempsey, G.I., Tan, M.H., Breckenridge, W.C., Johnston, D.E.,

Relation genetic polymorphism of apolipoprotein E, angiotensin converting enzyme, apoprotein B-

, glycoprotein

a and early-onset coronary heart disease. Clin. Biochem.

,

–

O’Hara, R., Yesavage, J.A., Kraemer, H.C., Mauricio, M., Friedman, L.F., Murphy, G.M.,

APOE epsilon

is associated with decline on delayed recall performance in older adults. J. Am. Geriatr. Soc.

,

–

Rea, I.M., M

aster, D., Woodside, J.V., Young, I.S., Archbold, G.P.R., Linton, T., Lennox, M

ulty, H., Harmon, D.L., Whitehead, A.S.,

Community-living nonagenarians in Ireland have a lower plasma homocysteine but similar methylenetetrahydrofolate reductase labile genotype prevalence compared to

–

year old subjects. Atherosclerosis

,

–

Rulu, G., Cassader, M., Gambino, R., Alemanno, N., Demichieli, F., Pagano, A., Veglia, F., G.,

Apolipoprotein E allele frequencies in Italian populations: relation of age and lipid Aging Clin. Exp. Res.

,

–

Schachter, F., Faure-Delanef, L., Guenot, F., Rouger, H., Froguel, P., Lesueur-Ginot, L., Cohen,

Genetic associations with human longevity at the Ap

and ACE loci. Nat. Genet.

, Smith, J.D.,

Apolipoprotein E

: an allele associated with many diseases. Ann. Med.

, Tunstall-Pedoe, T., Kuulasmaa, K., Amouyel, P., Arveiler, D., Rajakangas, A.M., Pajek, A., WHO MONICA project. Circulation

,

–

Utermann, G.,

Apolipoprotein E polymorphism in health and disease. Am. Heart J.

, Xhignesse, M., Lussier-Cacan, S., Sing, C.F., Kessling, A.M., Davignon, J.,

Influences of variants of apolipoprotein E on measures of lipid metabolism in a sample selected for Arterioscl. Thromb.

,

–

Zehraoui, L., Lagarde, J.P., Raisonnier, A., Gerard, N., Aouizerate, A., Lucotte, G.,

frequency of the apolipoprotein E*

allele in African pygmies and most of the African in sub-saharan Africa. Hum. Biol.

,

–

Schachter, F., Faure-Delanef, L., Guenot, F., Rouger, H., Froguel, P., Lesueur-Ginot, L., Cohen, D., 1994. Genetic associations with human longevity at the ApoE and ACE loci. Nat. Genet. 6, 29–32. Smith, J.D., 2000. Apolipoprotein E4: an allele associated with many diseases. Ann. Med. 32, 119–127. Tunstall-Pedoe, T., Kuulasmaa, K., Amouyel, P., Arveiler, D., Rajakangas, A.M., Pajek, A., 1994.

Zehraoui, L., Lagarde, J.P., Raisonnier, A., Gerard, N., Aouizerate, A., Lucotte, G., 1997. High frequency of the apolipoprotein E*4 allele in African pygmies and most of the African populations in sub-saharan Africa. Hum. Biol. 69, 575–581.