PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet.

,

–

Rosvall, L., Rizzuto, D., Wang, H.X., Winblad, B., Graff, C., Fratiglioni, L.,

APOE-related mortality: effect of dementia, cardiovascular disease and gender. Neurobiol. Aging

,

–

Sebastiani, P., Montano, M., Puca, A., Solovieff, N., Kojima, T., Wang, M.C., Melista, E., Meltzer, M., Fischer, S.E., Andersen, S., Hartley, S.H., Sedgewick, A., Arai, Y., Bergman, A., Barzilai, N., Terry, D.F., Riva, A., Anselmi, C.V., Malovini, A., Kitamoto, A., Sawabe, M., Arai, T., Gondo, Y., Steinberg, M.H., Hirose, N., Atzmon, G., Ruvkun, G., Baldwin, C.T., Perls, T.T.,

RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PL

One

, e

Shi, H., Medway, C., Bullock, J., Brown, K., Kalsheker, N., Morgan, K.,

Analysis of Genome-Wide Association Study (GWAS) data looking for replicating signals in Alzheimer’s disease (AD). Int. J. Mol. Epidemiol. Genet.

,

–

Suh, Y., Atzmon, G., Cho, M.O., Hwang, D., Liu, B., Leahy, D.J., Barzilai, N., Cohen, P.,

Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc. Natl. Acad. Sci. U. S. A.

,

–

Taioli, E., Mari, D., Franceschi, C., Bonafè, M., Monti, D., Bertolini, S., Marinelli, D., Garte, S.,

Polymorphisms of drug-metabolizing enzymes in healthy nonagenarians and centenarians: difference at GSTT

locus. Biochem. Biophys. Res. Commun.

,

–

Tan, Q., Zhao, J.H., Li, S., Kruse, T.A., Christensen, K.,

Power assessment for genetic association study of human longevity using offspring of long-lived subjects. Eur. J. Epidemiol.

,

–

Willcox, B.J., Donlon, T.A., He, Q., Chen, R., Grove, J.S., Yano, K., Masaki, K.H., Willcox, D.C., Rodriguez, B., Curb, J.D.,

FOXO

A genotype is strongly associated with human longevity. Proc. Natl. Acad. Sci. U. S. A.

,

–

Yu, C.E., Seltman, H., Peskind, E.R., Galloway, N., Zhou, P.X., Rosenthal, E., Wijsman, E.M., Tsuang, D.W., Devlin, B., Schellenberg, G.D.,

Comprehensive analysis of APOE and selected proximate mark- ers for late-onset Alzheimer’s disease: patterns of linkage disequilib- rium and disease/marker association. Genomics

,

–

neur, L., Bettens, K., Berr, C., Pasquier, F., Fievet, N., Barberger-Gateau, P., Engelborghs, S., De Deyn, P., Mateo, I., Franck, A., Helisalmi, S., Porcellini, E., Hanon, O., de Pancorbo, M.M., Lendon, C., Dufouil, C., Jaillard, C., Leveillard, T., Alvarez, V., Bosco, P., Mancuso, M., Panza, F., Nacmias, B., Bossu, P., Piccardi, P., Annoni, G., Seripa, D., Galimberti, D., Hannequin, D., Licastro, F., Soininen, H., Ritchie, K., Blanche, H., Dartigues, J.F., Tzourio, C., Gut, I., Van Broeckhoven, C., Alperovitch, A., Lathrop, M., Amouyel, P., 2009. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer’s disease. Nat. Genet. 41, 1094–1099. F., Marchegiani, F., Franceschi, C., 2009. PON1 is a longevity

A., Helisalmi, S., Porcellini, E., Hanon, O., de Pancorbo, M.M., Lendon, C., Dufouil, C., Jaillard, C., Leveillard, T., Alvarez, V., Bosco, P., Mancuso, M., Panza, F., Nacmias, B., Bossu, P., Piccardi, P., Annoni, G., Seripa, D., Galimberti, D., Hannequin, D., Licastro, F., Soininen, H., Ritchie, K., Blanche, H., Dartigues, J.F., Tzourio, C., Gut, I., Van Broeckhoven, C., Alperovitch, A., Lathrop, M., Amouyel, P.,

Genome-wide association study identifies variants at CLU and CR

associated with Alzheimer’s disease. Nat. Genet.

,

–

Lescai, F., Marchegiani, F., Franceschi, C.,

PON

is a longevity gene: results of a meta-analysis. Ageing Res. Rev.

,

–

Lewis, S.J., Brunner, E.J.,

Methodological problems in genetic association studies of longevity—the apolipoprotein E gene as an example. Int. J. Epidemiol.

,

–

Lobo, A., Launer, L.J., Fratiglioni, L., Andersen, K., Di Carlo, A., Breteler, M.M., Copeland, J.R., Dartigues, J.F., Jagger, C., Martinez-Lage, J., Soininen, H., Hofman, A.,

Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology

, S

–S

M

arthy, M.I., Abecasis, G.R., Cardon, L.R., Goldstein, D.B., Little, J., Ioannidis, J.P., Hirschhorn, J.N.,

Genome-wide association stud- ies for complex traits: consensus, uncertainty and challenges. Nat. Rev. Genet.

,

–

M

ue, M., Vaupel, J.W., Holm, N., Harvald, B.,

Longevity is moderately heritable in a sample of Danish twins born

–

J. Gerontol.

, B

–B

Naj, A.C., Jun, G., Beecham, G.W., Wang, L.S., Vardarajan, B.N., Buros, J., Gallins, P.J., Buxbaum, J.D., Jarvik, G.P., Crane, P.K., Larson, E.B., Bird, T.D., Boeve, B.F., Graff-Radford, N.R., De Jager, P.L., Evans, D., Schneider, J.A., Carrasquillo, M.M., Ertekin-Taner, N., Younkin, S.G., Cruchaga, C., Kauwe, J.S., Nowotny, P., Kramer, P., Hardy, J., Huentelman, M.J., Myers, A.J., Barmada, M.M., Demirci, F.Y., Bald- win, C.T., Green, R.C., Rogaeva, E., St. George-Hyslop, P., Arnold, S.E., Barber, R., Beach, T., Bigio, E.H., Bowen, J.D., Boxer, A., Burke, J.R., Cairns, N.J., Carlson, C.S., Carney, R.M., Carroll, S.L., Chui, H.C., Clark, D.G., Corneveaux, J., Cotman, C.W., Cummings, J.L., Decarli, C., Dekosky, S.T., Diaz-Arrastia, R., Dick, M., Dickson, D.W., Ellis, W.G., Faber, K.M., Fallon, K.B., Farlow, M.R., Ferris, S., Fro- sch, M.P., Galasko, D.R., Ganguli, M., Gearing, M., Geschwind, D.H., Ghetti, B., Gilbert, J.R., Gilman, S., Giordani, B., Glass, J.D., Grow- don, J.H., Hamilton, R.L., Harrell, L.E., Head, E., Honig, L.S., Hulette, C.M., Hyman, B.T., Jicha, G.A., Jin, L.W., Johnson, N., Karlawish, J., Karydas, A., Kaye, J.A., Kim, R., Koo, E.H., Kowall, N.W., Lah, J.J., Levey, A.I., Lieberman, A.P., Lopez, O.L., Mack, W.J., Marson, D.C., Martiniuk, F., Mash, D.C., Masliah, E., M

ormick, W.C., M

urry, S.M., M

avid, A.N., M