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!& , Boitard, ( .!& , Froguel, }

!& , Lathrop, } #!& , Bell, J

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/! . Susceptibility y to insulin ¢

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A! . Sex-specific > quantitative t > trait loci z i affecting | OT MLM NES”: longevity i yin |

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A/

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)!& oon, Toth, ! #!

!& , Ades, |

!>!& OE BIIES PIII RSID IIE WA, Calles-Escandon, J

!& (cid:

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A! . Gender r differences i Sint  | resting

x metabolic r > rate and

! noradrenaline | kinetics i

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older i r individuals. | =(cid:

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! . Clin. | . Invest.

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factor I r II ( [ (IGF I * TT) locus « ON

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)! . Measuring t

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modulating t the | > human |

lifespan: §  Bey ey EET: gene—environment i t interaction <

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ewe> genetic « > effect. | . Biogerontology

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press. Weir, | )!(cid:

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)

@! a ~ eoe. Genetic | > Data / er

Analysis | s II. § mes = '. Sinauer / = APS AMO Oer Associates, §  , Sunderland, | #> . pp. §

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D! Jazwinski, ‘ (cid:

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! ‘ou. Aging ¢ EVrand |

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