) Arylamine N-acetyltransferase (NAT

) mutations and their allelic linkage in unrelated Caucasian individuals: cor- relation with phenotypic activity. Am J Hum Genet

:

–

Cholerton S, Daly AK, Idle JR (

) The role of individual human cytochromes P

in drug metabolism and clinical response. Trends Pharmacol Sci

:

–

Daly AK, Thomas DJ, Cooper J, Pearson WR, Neal DE, Idle JR (

) Homozygous deletion of the gene for glutathione S-trans- ferase M

in bladder cancer Br Med J

:

–

Daly AK, Cholerton S, Armstrong M, Iddle JR (

) Genotyping for polymorphism in xenobiotic metabolism as a predictor of disease susceptibility. Environ Health Perspect

:

–

Daly AK, Brockmöller J, Broly F, Eichelbaum M, Evans WE, Gonzalez FJ, Huang JD, Idle JR, Ingelman-Sundberg M, Ishizaki T, Jacqz-Aigrain E, Meyer UA, Nebert DW, Steen VM, Wolf CR, Zanger UM (

) Nomenclature for human CYP

D

alle- les. Pharmacogenesis

:

–

Dausset J, Cann H, Cohen D, Lathrop M, Lalouel JM, White R (

) Centre d’etude du polymorphisme humain (CEPH): col- laborative genetic mapping of the human genome. Genomics

:

–

Heagerty AHM, Fitzgerald D, Smith A, Bowers B, Jones P, Fryer AA, Zhao L, Alldersea J, Strange RC (

) Glutathione S- transferase GSTM

phenotypes and protection against cutaneous tumours. Lancet

:

–

Hickman D, Sim E (

) N-Acetyltransferase polymorphism: com- parison of phenotype and genotype in humans. Biochem Phar- macol

:

–

Hirvonen A (

) Genetic factors in individual responses to envi- ronmental exposures. J Occup Environ Med

:

–

Hirvonen A, Pelin K, Tammilehto L, Karjalainen A, Mattson K, Linnainmaa K (

) Inherited GSTM

and NAT

defects as concurrent risk modifiers in asbestos-related human malignant mesothelioma. Cancer Res

:

–

Johnson TE (

) Genetic influences on aging. Exp Gerontol

:

–

Ketterer B, Harris JM, Talaska G, Meyer DJ, Pemble SE, Taylor JB, Lang NP, Kadlubar FF (

) The human glutathione S-trans- ferase supergene family, its polymorphism and its effects on sus- ceptibility to lung cancer. Environ Health Perspect

:

–

Korrapati MR, Sorkin JD, Andres R, Muller DC, Loi C, Vessel ES, Vestal RE (

) Acetylator phenotype in relation to age and gender in the Baltimore longitudinal study of aging. J Clin Phar- macol

:

–

Laurent-Kenesi MA, Jacqz-Aigrain E, Lejonc JL, Jaillon P, Funck- Brentano C (

) Assessment of CYP

D

activity in very eld- erly healthy subjects. Fundam Clin Pharmacol

:

Lin HJ, Han C, Lin BK, Hardy S (

) Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT

) gene Pharmacogenetics

:

–

Lucotte G, Turpin JC, Gerard N, Panserat S, Krishnamoorthy R (

) Mutation frequencies of the cytochrome CYP

D

gene in Parkinson disease patients and in families. Am J Med Genet

:

–

Mannervik B, Awasthi YC, Board PG, Hayes JD, Di Ilio C, Ketterer B, Listowsky I, Morgenstern R, Muramatsu M, Pearson WP, Pickett CB, Sato K, Widersten M, Wolf CR (

) Nomencla- ture for human glutathione transferases. Biochem J

:

–

M

aren EH, Burden AC, Moorhead PJ (

) Acetylator pheno- type in diabetic neuropathy. Br Med J

:

–

Mrozikiewicz PM, Drakoulis N, Roots I (

) Polymorphic aryl- amine N-acetyltransferase (NAT

) genes in children with insu- lin-dependent diabetes mellitus. Clin Pharmacol Ther

:

–

Olshansky SJ, Carnes BA, Cassel C (

) In search of Methuselah: estimating the upper limits to human longevity. Science

:

–

Cascorbi I, Drakoulis N, Brockmöller J, Maurer A, Sperling K, Roots I (

) Arylamine N-acetyltransferase (NAT

) mutations and their allelic linkage in unrelated Caucasian individuals: cor- relation with phenotypic activity. Am J Hum Genet

:

–

Cholerton S, Daly AK, Idle JR (

) The role of individual human cytochromes P

in drug metabolism and clinical response. Trends Pharmacol Sci

:

–

Daly AK, Thomas DJ, Cooper J, Pearson WR, Neal DE, Idle JR (

) Homozygous deletion of the gene for glutathione S-trans- ferase M

in bladder cancer Br Med J

:

–

Daly AK, Cholerton S, Armstrong M, Iddle JR (

) Genotyping for polymorphism in xenobiotic metabolism as a predictor of disease susceptibility. Environ Health Perspect

:

–

Daly AK, Brockmöller J, Broly F, Eichelbaum M, Evans WE, Gonzalez FJ, Huang JD, Idle JR, Ingelman-Sundberg M, Ishizaki T, Jacqz-Aigrain E, Meyer UA, Nebert DW, Steen VM, Wolf CR, Zanger UM (

) Nomenclature for human CYP

D

alle- les. Pharmacogenesis

:

–

Dausset J, Cann H, Cohen D, Lathrop M, Lalouel JM, White R (

) Centre d’etude du polymorphisme humain (CEPH): col- laborative genetic mapping of the human genome. Genomics

:

–

Heagerty AHM, Fitzgerald D, Smith A, Bowers B, Jones P, Fryer AA, Zhao L, Alldersea J, Strange RC (

) Glutathione S- transferase GSTM

phenotypes and protection against cutaneous tumours. Lancet

:

–

Hickman D, Sim E (

) N-Acetyltransferase polymorphism: com- parison of phenotype and genotype in humans. Biochem Phar- macol

:

–

Pearson WR, Vorachek WR, Xu S, Berger R, Hart I, Vannais Patterson D (

) Identification of class-mu glutathione ferase genes GSTM

–GSTM

on human chromosome

p

J Hum Genet:

:

–

Pirmohamed M, Wild MJ, Kitteringham NR, O’Brien K, Buchan Back DJ, Park BK (

) Lack of association between phrenia and the CYP

D

gene polymorphisms. Am J Med

:

–

Poirier J, Roy M, Campanella G, Cloutier T, Paris S Debrisoquine metabolism in Parkinsonian patients treated antihistamine drugs. Lancet

:

Proust J, Moulias R, Fumeron F, Bekkhoucha F, Busson M, M, Hors J (

) HLA and longevity. Tissue Antigens

–

Rattan SIS (

) Ageing – a biological perspective. Mol Med

:

–

Sachse C, Brockmöller J, Bauer S, Roots I (

) Cytochrome

D

variants in a Caucasian population: allele frequencies phenotypic consequences. Am J Hum Genet

:

–

Sambrook J, Fritsch EF, Maniatis T (

) Molecular cloning: a lab- oratory manual,

nd edn. Cold Spring Harbor Laboratory Cold Spring Harbor, NY Schächter F, Cohen D, Kirkwood TBL (