,

–

Menuz V, Howell KS, Gentina S, Epstein S, Riezman I, Fornallaz-Mul- hauser M, Hengartner MO, Gomez M, Riezman H, Martinou JC (

) Protection of C. elegans from anoxia by HYL-

ceramide syn- thase. Science

,

–

Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lan- francone L, Pelicci PG (

) The p

shc adaptor protein controls oxidative stress response and life span in mammals. Nature

,

–

Ogretmen B, Hannun Y (

) Biologically active sphingolipids in can- cer pathogenesis and treatment. Nat. Rev. Cancer

,

–

Pritchard JK, Stephens M, Donnelly P (

) Inference of population structure using multilocus genotype data. Genetics

,

–

Evert J, Lawler E, Bogan H, Perls T (2003) Morbidity profiles of cente- narians: survivors, delayers, and escapers. J. Gerontol. A Biol. Sci.

Ramos KS (1999) Redox regulation of c-Ha-ras and osteopontin signal- ing in vascular smooth muscle cells: implications in chemical athero-

ing in vascular smooth muscle cells: implications in chemical genesis. Annu. Rev. Pharmacol. Toxicol.

,

–

Ray DA, Walker JA, Hall A, Llewellyn B, Ballantyne J, Christian AT, teltaub K, Batzer MA (

) Inference of human geographic using Alu insertion polymorphisms. Forensic Sci. Int.

,

–

Rockwood K, Mitnitski A (

) Frailty in relation to the of deficits. J. Gerontol. A Biol. Sci. Med. Sci.

,

–

Sanchez MS, Basten CJ, Ferrenberg AM, Asmussen MA, Arnold (

) Exact sample sizes needed to detect dependence in

x tables. Theor. Popul. Biol.

,

–

Scha¨chter F, Faure-Delanef L, Gue´not F, Rouger H, Froguel P, Ginot L, Cohen D (

) Genetic associations with human at the APOE and ACE loci. Nat. Genet.

,

–

Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K (

) standard procedure for creating a frailty index. BMC Geriatr.

,

Song Y, Stampfer MJ, Liu S (

) Meta-analysis: apolipoprotein genotypes and risk for coronary heart disease. Ann. Intern.

,

–

Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, J, Salvesen GS, Roses AD (

) Apolipoprotein E: high-avidity ing to beta-amyloid and increased frequency of type

allele in onset Alzheimer disease. Proc. Natl Acad. Sci. USA

,

–

Suh Y, Atzmon G, Cho MO, Hwang D, Liu B, Leahy DJ, Barzilai Cohen P (

) Functionally significant insulin-like growth factor receptor mutations in centenarians. Proc. Natl Acad. Sci. USA

–

Sun J, Kale SP, Childress AM, Pinswasdi C, Jazwinski SM (

) gent roles of RAS

and RAS

in yeast longevity. J. Biol. Chem.

–

Tedesco P, Jiang J, Wang J, Jazwinski SM, Johnson TE (

) analysis of hyl-

, the C. elegans homolog of LAG

⁄LASS

Age

–

Terry DF, Sebastiani P, Andersen SL, Perls TT (

) Disentangling roles of disability and morbidity in survival to exceptional old Arch. Intern. Med.

,

–

Thornton-Wells TA, Moore JJ, Haines JL (

) Genetics, statistics human disease: analytical retooling for complexity. Trends

,

–

Tishkoff SA, Pakstis AJ, Ruano G, Kidd KK (

) The accuracy statistical methods for estimation of haplotype frequencies: example from the CD

locus. Am. J. Hum. Genet.

,

–

Watkins WS, Rogers AR, Ostler CT, Wooding S, Bamshad MJ, sington AM, Carroll ML, Nguyen SV, Walker JA, Prasad BV, PG, Das PK, Batzer MA, Jorde LB (

) Genetic variation world populations: inferences from

Alu insertion phisms. Genome Res.

,

–

Willcox BJ, Donlon TA, He Q, Chen R, Grove JS, Yano K, Masaki Willcox DC, Rodriguez B, Curb JD (

) FOXO

A genotype strongly associated with human longevity. Proc. Natl Acad. Sci.

,

–

Witting SR, Maiorano JN, Davidson WS (

) Ceramide cholesterol efflux to apolipoprotein A-I by increasing the cell presence of ATP-binding cassette transporter A

J. Biol.

,

–

Woo JG, Dolan LM, Deka R, Kaushal RD, Shen Y, Pal P, Daniels Martin LJ (

) Interactions between noncontiguous haplotypes the adiponectin gene ACDC are associated with plasma tin. Diabetes

,

–

Zhao J, Jin L, Xiong M (

) Test for interaction between unlinked loci. Am. J. Hum. Genet.

,

–

Excoffier L, Laval G, Schneider S (

) Arlequin ver.

: an inte- grated software package for population genetics data analysis. Evol. Bioinform. Online

,

–

Finch CE, Ruvkun G (

) The genetics of aging. Annu. Rev. Genom- ics Hum. Genet.

,

–

Flint J, Mackay TF (

) Genetic architecture of quantitative traits in mice, flies, and humans. Genome Res.

,

–

Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, D

elice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D (

) The structure of haplotype blocks in the human genome. Science

,

–

Guillas I, Jiang JC, Vionnet C, Roubaty C, Uldry D, Chuard R, Wang J, Jazwinski SM, Conzelmann A (

) Human homologues of LAG

reconstitute Acyl-C

-dependent ceramide synthesis in yeast. J. Biol. Chem.

,

–

Hong MG, Reynolds C, Gatz M, Johansson B, Palmer JC, Gu HF, Blen- now K, Kehoe PG, de Faire U, Pedersen NL, Prince JA (

) Evidence that the gene encoding insulin degrading enzyme influ- ences human lifespan. Hum. Mol. Genet.

,

–

Jazwinski SM (

) Longevity, genes, and aging. Science

,

–

Jazwinski SM, Conzelmann A (

) LAG

puts the focus on ceramide signaling. Int. J. Biochem. Cell Biol.

,

–

Jiang JC, Kirchman PA, Allen M, Jazwinski SM (

) Suppressor anal- ysis points to the subtle role of the LAG

ceramide synthase gene in determining yeast longevity. Exp. Gerontol.

,

–

Kenyon C (

) The plasticity of aging: insights from long-lived

Scha¨chter F, Faure-Delanef L, Gue´not F, Rouger H, Froguel P, Lesueur- Ginot L, Cohen D (1994) Genetic associations with human longevity

longevity assurance gene

in human head and neck squamous cell carcinomas. J. Biol. Chem.

,

–

Kulminski AM, Ukraintseva SV, Culminskaya IV, Arbeev KG, Land KC, Akushevich L, Yashin AI (

) Cumulative deficits and physiological indices as predictors of mortality and long life. J. Gerontol. A Biol. Sci. Med. Sci.

,

–