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environmental factors may be responsible for the variation of unfavorable effect of e4 allele in aged populations.

ACKNOWLEDGMENTS

This study was supported by a grant from the Hellenic Endocrine Society.

Drs. Stakias and Liakos contributed equally.

Address correspondence to George N. Koukoulis, MD, Assistant Professor of Internal Medicine/Endocrinology, University Hospital, De- partment of Internal Medicine, Mezurlo Hill, 41110, Larissa, Greece. E-mail: gnkouk@med.uth.gr

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