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The role of sex differences in age trajectories is still unresolved. Our data shows that the RANTES genetic component differs between males and females and could contribute to their differences in aging trajectories. The appropriate regulation of the inflammatory response by a proper balance of pro- and anti-inflammatory cytokines could be an important factor in reaching extreme longevity. Assuming all the limitations previously mentioned, our results encourage further studies to replicate our findings and to search for additional inflammation-related genes that could define an inflammation-related genetic component contributing to