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group of individuals, and no population stratification was detected in our study participants.

Since the cases and controls had an average age differ- ence of 11 years, we cannot completely exclude the possi- bility that differences in birth cohorts were a confounding factor. This seems unlikely since there was only a 19-year difference in birth years from oldest to youngest, and suba- nalyses revealed there were no differences in education and occupation between cases and controls (data not shown). Moreover, those participants who were older at baseline were more likely to have lived to 95 years, whereas most cohort effects show health advantages for younger cohorts. In conclusion, this study has found no association of

genetic variation in ATF4, CBL, CDKN2, EXO1, and JUN with longevity in American men of Japanese ancestry study participants. Studies of these genes in other populations may be of merit.

from http://biomedgerontology.oxfordjournals.org/ at New York University on July 8, 2015

Supplementary material can be found at: http://biomedgerontology. oxfordjournals.org/

Funding

This research was supported by the National Institute on Aging number 5r01AG027060-06 (Kuakini Hawaii Lifespan Study) and number 5r01AG038707-02 (Kuakini Hawaii Healthspan Study), each B.J.W.

Acknowledgments

The authors thank Christine Imamura, Hiromi Nakada, and Sayaka Mitsuhashi for their helpful assistance in the research conducted.

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