Hara K, Maruki Y, Long X, et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. ; :

Sarbassov DD, Ali SM, Kim DH, et al. Rictor, a novel binding partner of OR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol. ; :

Laplante M, Sabatini DM. OR signaling in growth control and disease. Cell. ; : doi: /j.cell.

Yip CK, Murata K, Walz T, Sabatini DM, Kang SA. Structure of the human OR complex I and its implications for rapamycin inhibition. Mol Cell. ; : doi: /j.molcel.

Magnuson B, Ekim B, Fingar DC. Regulation and function of ribosomal protein S kinase (SK) within OR signaling networks. Biochem J. ; : doi: /BJ

Um SH, DAlessio D, Thomas G. Nutrient overload, insulin resistance, and ribosomal protein S kinase , SK cell Metab. ; :

Selman C, Tullet JM, Wieser D, et al. Ribosomal protein S kinase signaling regulates mammalian lifespan. Science. ; : doi: /science.

Worth RM, Kagan A. Ascertainment of men of Japanese ancestry in Hawaii through World War II Selective Service registration. J Chronic Dis. ; :

Kagan A, ed. The Honolulu Heart Program: an epidemiological Study of coronary Heart Disease and Stroke. Amsterdam, The Netherlands: Harwood Academic Publishers;

Arias E. United States life tables, Hyattsville, MD: National Center for Health Statistics; : ( ).

Nordyke EC, Lee R, Gardner RW. A profile of Hawaii's elderly population. Papers east West Popul Inst. ; :

We thank Maarit Tiirikainen, Randi Chen, and Sayaka Mitsuhashi for their helpful assistance in the research conducted. The authors declared no conflict of interest.

Sebastiani P, Perls TT. The genetics of extreme longevity: lessons from the New England centenarian study. Front Genet. ; : doi: /fgene

Beekman M, Blanch H, Perola M, et al.; GEHA consortium. Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study. Aging Cell. ; : doi: /acel.

Murabito JM, Yuan R, Lunetta KL. The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals. J Gerontol A Biol Sci Med Sci. ; : doi: /gerona/gls

Mair W, Dillin A. Aging and survival: the genetics of life span extension by dietary restriction. Annu Rev Biochem. ; : doi: /annurev.biochem.

Willcox BJ, Donlon TA, He Q, et al. FOXO A genotype is strongly associated with human longevity. Proc Natl Acad Sci U S A. ; : doi: /pnas.

Gems D, Partridge L. Genetics of longevity in model organisms: debates and paradigm shifts. Annu Rev Physiol. ; : doi: /annurev-physiol-

Curran SP, Ruvkun G. Lifespan regulation by evolutionarily conserved genes essential for viability. Pl Genet. ; :e

Pan Y, Nishida Y, Wang M, Verdin E. Metabolic regulation, mitochondria and the life-prolonging effect of rapamycin: a mini-review. Gerontology. ; : doi: /

Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol. ; :

Kaeberlein M, Powers RW rd, Steffen KK, et al. Regulation of yeast replicative life span by TOR and Sch in response to nutrients. Science. ; :

Fadini GP, Ceolotto G, Pagnin E, de Kreutzenberg S, Avogaro A. At the crossroads of longevity and metabolism: the metabolic syndrome and lifespan determinant pathways. Aging Cell. ; : doi: /j.-x

Wu JJ, Liu J, Chen EB, et al. Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of ORThe processed text is already in the correct format and does not require any changes.