References

atherosclerotic heart disease. N Engl J Med

;

:

–

Ridker PM: Inflammation, atherosclerosis, and cardiovascular risk: an epidemiologic view. Blood Coagul Fibrinolysis

;

: S

–S

Cheng S, Grow MA, Pallaud C et al: A multilocus genotyping assay for candidate markers of cardiovascular disease risk. Genome Research

;

:

–

Navab M, Berliner JA, Subbanagounder G et al: HDL and the inflammatory response induced by LDL-derived oxidized phospholipids. Arterioscler Thromb Vasc Biol

;

:

–

Watson AD, Berliner JA, Hama SY et al: Protective effect of high density lipoprotein associated paraoxonase: inhibition of the biological activity of minimally oxidized low density lipopro- tein. J Clin Invest

;

:

–

Ross R: Atherosclerosis – an inflammatory disease. The New Eng J Med

;

:

–

Adkins S, Gan KN, Mody M, La Du BN: Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: glutamine or arginine at position

, for the respective A or B allozymes. Am J Hum Genet

;

:

–

Blatter-Garin MC, James RW, Dussoix P et al: Paraoxonase polymorphism Met-Leu

is associated with modified serum concentrations of the enzyme. J Clin Invest

;

:

–

Durrington PN, Mackness B, Mackness MI: Paraoxonase and atherosclerosis. Arterioscler Thromb Vasc Biol

;

:

–

Ombres D, Pannitteri G, Montali A et al: The gln-Arg

polymorphism of human paraoxonase gene is not associated with coronary artery disease in Italian patients. Arterioscler Thromb Vasc Biol

;

:

–

Paolisso G, Manzella D, Tagliamonte MR et al: The BB- paraoxonase genotype is associated with impaired brachial reactivity after acute hypertriglyceridemia in healthy subjects. J Clin Endocrinol Metab

;

:

–

Heijmans BT, Westendorp RG, Lagaay AM, Knook DL, Kluft C, Slagboom PE: Common paraoxonase gene variants, mortality risk and fatal cardiovascular events in elderly subjects. Athero- sclerosis

;

:

–

Miller SA, Dykes DD, Polesky HF: A simple salting-out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res

;

:

Humbert R, Adler DA, Disteche CM, Hassett C, Omiecinski CJ, Furlong CE: The molecular basis of the human serum para- oxonase activity polymorphism. Nat Genet

;

:

–

Guo SW, Thompson EA: A Monte Carlo method for combined segregation and linkage analysis. Am J Hum Genet

;

:

–

Schneider S, Roessli D, Excoffier L: Arlequin ver

: a software for population genetics data analysis. Genetics and Biometry Laboratory, Switzerland: University of Geneva.

Franceschi C, Bonafe M, Valensin S et al: Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci

;

:

–

De Benedictis G, Qihua Tan, Jeune B et al: Recent advances in human gene/longevity association studies. Mech Ageing Dev

;

:

–

Yashin AI, Ukraintseva SV, De Benedictis G et al: Have the oldest old adults ever been frail in the past? A hypothesis that explains modern trends in survival. J Gerontol A Biol Sci

;

: B

–

Hegele RA: Paraoxonase genes and disease. Ann Med

;

:

–

Dessi M, Gnasso A, Motti C et al: Influence of the human paraoxonase polymorphism (PON

) on the carotid-wall thickening in a healthy population. Coron Artery Dis

;

:

–

Zuliani G, Ble’ A, Zanca R et al: Genetic polymorphisms in older subjects with vascular or Alzheimer’s dementia. Acta Neurol Scand

;

:

–

Herrmann SM, Blanc H, Poirier O et al: The Gln/Arg poly- morphism of human paraoxonase (PON

) is not related to myocardial infarction in the ECTIM Study. Atherosclerosis

;

:

–

Senti M, Aubo C, Tomas M: Differential effects of smoking on myocardial infarction risk according to the Gln/Arg

variants of the human paraoxonase gene. Metabolism

;

:

–

Leus FR, Wittekoek ME, Prins J, Kastelein JJ, Voorbij HA: Paraoxonase gene polymorphisms are associated with carotid arterial wall thickness in subjects with familial hypercholester- olemia. Atherosclerosis

;

:

–

Senti M, Tomas M, Marrugat J, Elosua R: REGICOR Investigators. Paraoxonase

-

polymorphism modulates the nonfatal myo- cardial infarction risk associated with decreased HDLs. Arter- ioscler Thromb Vasc Biol

;

:

–

Mannucci PM, Mari D, Merati G et al: Gene polymorphisms predicting high plasma levels of coagulation and fibrinolysis proteins. A study in centenarians. Arterioscler Thromb Vasc Biol

;

:

–

Robine JM, Forette C, Franceschi C:

The paradoxes of longevity. Allard M (ed): New York: Springer-Verlag.

Rose G, Passarino G, Carrieri G et al: Paradoxes in longevity: sequence analysis of m

NA haplogroup J in centenarians. Eur J Hum Genet

:

–

Bonafe` M, Barbi C, Olivieri F et al:

An allele of HRAS

’ variable number of tandem repeats is a frailty allele: implication for an evolutionary conserved pathway involved in longevity. Gene

:

–

Franceschi C, Valensin S, Bonafe M et al: The network and the remodeling theories of aging: historical background and new perspectives. Exp Gerontol

;

:

–