Appendix A. Supplementary data
Supplementary data associated with this article can be found in the online version at doi:10.1016/j.neurobiolaging.2007.05.003.

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Considering the complexity of the mechanisms leading to transcriptional and translational regulation of VEGF expression, additional polymorphisms (also located within the VEGF coding region) may be responsible for the positive association with long-term aging. Furthermore, this study opens the question about the role of other angiogenic factors strikingly similar to VEGF on successful aging; in fact, angiogenin and progranulin have been recently associated with neurodegenerative disorders and represent molecules with important neuroprotective activities (Baker et al.,