Materials andThe text appears to be well-written and free of errors. As an AI language model, I do not have the ability to determine the accuracy of the scientific information presented in the text.Screening for the presence of modifier polymorphisms in addition to direct measurements of the plasma levels of IL-10 and TNF-a is warranted in future studies (Makhatadze, 1998; Cacev et al., 2008). In this study, we asked whether cytokine gene polymorphisms could account for one part of the genetic component of longevity in the Jordanian population. The data showed that no statistically significant differences were found between the elderly and controls when comparing genotype distributions and allele frequencies of the 1082 GA IL-10 promoter and the 308 GA TNF-a promoter SNPs. However, when gender is considered, the 1082 GA IL-10 genotype and allele frequencies were significantly associated with longevity in men but not in women. This result is consistent with previous observations by Lio et al. (2003) on the Italian population. Gender has been shown to be a major variable in the genetics of longevity in different populations. For example, Adiponectin, peroxisome proliferator-activated receptor (PPAR)gamma-2, IL-6, and Tyrosine Hydroxylase genes have been associated with longevity in men but not in women (Bonafe et al., 2001; De Luca et al., 2001; Barbieri et al., 2004; Atzmon et al., 2008). On the other hand, haemochromatosis, interferon-gamma, and Apo C-I gene polymorphisms are associated with longevity in women but not in men (Galinsky et al., 1997; Lio et al., 2002a,c, 2003). This indicates that men and women might follow different pathways to longevity. The mechanisms that explain the gender effect on the pathway to longevity are still unknown; however, gender differences in hormonal signalling pathways, immunity response, detoxification mechanisms, and oxidative damage tolerance might account for it. 

Conclusion: This is the first report to investigate the association of genetic loci and longevity in an Arabic population. The results of this study indicate that the IL-10 1082 GA promoter polymorphism plays a role in men but not in women's longevity, whereas TNF-a 308 GA promoter polymorphism plays no significant role in both men and women's longevity in the Jordanian population.

Acknowledgements: This work has been carried out with funds from the Faculty of Scientific Research in Jordan University of Science and Technology grant number 1822007 to O. K. The authors thank Dr M. Al-Omari for his comments on the manuscript and Mr E. S. Abdelhalim and Mr A. Abu-Wardeh for their technical help in the study.

References: Many studies have reported that IL-10 and TNF-a promoter polymorphisms are either associated or not associated with human longevity. Positive association of these polymorphism has been reported in the Italian and Bulgarian populations (Lio et al., 2002a,b; Naumova et al., 2004; Lee et al., 2005; Cardelli et al., 2008) whereas negative association with these polymorphisms has been reported in Finnish populations. Atzmon et al. (2008) found that Adiponectin levels and genotype are a potential regulator of lifespan in humans. Carrieri et al. (2004) found that the GC polymorphism of transforming growth factor beta is associated with human longevity, while Candore et al. (2006) found that inflammation, longevity, and cardiovascular diseases are related to polymorphisms of TLRs.I'm sorry, but the text you provided is a list of references and not a coherent piece of text. Therefore, there is no need for proofreading or improving it. Is there anything else I can help you with?There is no context or text enclosed in ``` ```. Please provide the text for me to proofread and improve.