Table 1. Clinical Characteristics of Study Population (n = 677) (90 percentile, 96-104 years).

|              | Control | Long Lived | All    |
|--------------|---------|------------|--------|
| Sex (male/female) | 289/388 | 239/231   | 50/157*|
| Age (y)      | 62 ± 26 | 48 ± 15     |        |
| BMI (kg/m2)  | 24.5 ± 3.2 | 25.1 ± 2.9   |        |
| Glucose (mmol/dL) | 4.8 ± 0.9 | 4.9 ± 0.8   |        |
| Insulin (mU/mL) | 10.6 ± 4.4 | 11.6 ± 4.2   |        |
| Triglycerides (mg/dL) |107 ±45|108 ±44||
| Total cholesterol (mg/dL) |198 ±42|201 ±41|.020|
| hDL cholesterol (mg/dL) | 51.2 ± 10.6 | 49.6 ± 8.4 |        |

Table 2. Allele and Genotype Distributions of the IRS2 Gene Variant in Control (mean age = 48 ± 15 years, age range = 16-83 years) and Long Lived (mean age = 96 ± 4 years, age range = 85-104 years).

| Genotype | Control (%) | Long Lived (%) | p-value |
|----------|-------------|----------------|---------|
| IRS2 Gly/Gly | 46.1 | 34.7 | c2 = 6.16; p = .04 |
| IRS2 Gly/Asp | 41.9 | 48.6 |        |
| IRS2 Asp/Asp | 12.0 | 16.7 |        |
| Allele frequency | Gly: 88.0, Asp:12.0 | Gly:83.3, Asp:16.7 | Fisher's test: p = |

Table 3. Multinomial Regression of Age in Percentiles as the Ordinal Dependent Variable and Cumulative Logit as the Link Function with hOMA2%B, and BMI and the Serum Concentration of Cholesterol, and hDL at Various Metabolic Parameters as (n = 677, male/female = 289/388, age range: 16-104 years).

| Parameter*   | Odds Ratio   | Lower CI   | Upper CI   | p-value |
|--------------|--------------|------------|------------|---------|
| Genotype     |
| IRS2Asp/Asp     |    2.03      |   1.39     |    2.99    |  .0003  |
| IRS2Gly/Asp     |    1.49      |   1.15     |    1.94    |  .003   |
| IRS2Gly/Gly     |       1      |      -     |       -    |         |
| Sex          |
| Female       |    1.49      |   1.16     |    1.91    |  .002   |
| Male         |       1      |      -     |       -    |         |
| Metabolic Parameters |
| hOMA2 IR     |    0.80      |   0.64     |    1.00    |  .051   |
| %B           |   0.998      |   0.995    |    1.000   |  .034   |
| BMI          |   0.934      |   0.900    |    0.970   | .0004   |
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