haplogroup in EN EER NAINA Icentenarians J peeindicates that the ee REEDJ-specific genetic IIEbackground oycan affect Beep es ee shlongevity, Peek eeepossibly by conferring increased owe Ee eeeresistance ~~ &to >the —— oNdeleterious effects of the AMEN NEST? PMSaccumulation | of | 2 Vy NM“mtDNA | EI NID II IDOmutations , with | age. | Similarly, - it is , important | to point | Out | that any   specific nucleotide, | or  haplogroup |  omdefining, |    repolymorphism |  a pees eeassociated | with ae) SPageing | ; may | not | t be « NE MNdirectly i Pee Peoinvolved | verb ™| but : i —)t simply « oolacting aS; ;al rea| marker { peesfor « other 1 ‘tightly | linked BONO RAO Fapolymorphisms « Oe ODoccurring « !E OO ———, elsewhere | in the 1 Py eee»mtDNA | oe eee. genome 1 that « directly ; Teen Eeaffect | pT OE| longevity. OE FOLIA EECertainly if | “the | EEE EDIEsignificant association | of | “the | & 7 NE ONhaplogroup with | eee Neageing is” NE EEO NEconfirmed in

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pen”Our { r findings « “o~; of < wane Peef age-associated 1 {mtDNA \ . variants i sin t 1 the | - Irish | 1 population « . certain!  the | » theory 1 eethat | the 1 NEE- mitochondrial | genome | > may | ’ play « fas | subtle 1 wee MErole 1 orein t | the ageing | meee J OEE, process < sand ON LINDEtherefore Fe eerequires | more | ENED DD ISDS ES: focussed | NE IIIA EE| gerontological 1 — veoresearch : | attention.

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