IL-10 is considered to mediate potent downregulation of inflammatory responses (32). Serum levels of IL-10 are decreased in patients with unstable angina, in keeping with data from animal studies which indicate that IL-10 plays a protective role in atherosclerosis (33). Some case-control studies do not support the role of IL-10 polymorphisms in CHD (34, 35). However, a recent study suggests that the 1082A allele, associated with low production of cytokine IL-10 and elevated markers of systemic inflammation such as C-reactive protein, is predictive of higher cardiovascular morbidity inMeenagh A, et al. conducted a study on age-related cytokine gene polymorphisms in an elderly Irish population. This study was published in the journal Mech Ageing Dev. Rea IM, Ross OA, Armstrong M, et al. investigated the IL-6 gene C/G polymorphism in nonagenarians and octogenarians participating in the BELFAST study. The study revealed reciprocal effects on IL-6, soluble IL-6 receptor, and IL-10 in serum and monocyte supernatants. This study was also published in Mech Ageing Dev. Lio D, Pes GM, Carru C, et al. conducted research on the association between HLA-DR alleles and longevity among the Sardinian population. The findings were published in Exp Gerontol. Passarino G, Underhill PA, Cavalli-Sforza LL., et al. used Y chromosome binary markers to investigate the high prevalence of males among Sardinian centenarians and the genetic structure of the Sardinian population. This study was published in Hum Hered. Vaupel JW studied mortality trajectories at advanced ages and published his findings in a book chapter titled "Trajectories of mortality at advanced age," which appears in The Biodemography of Longevity edited by Watcher KW and Finch CE and published by the National Academy Press. Scola L, Licastro F, Chiappelli M, et al. studied allele frequencies of +TA single nucleotide polymorphism at the first intron of IFN-gamma gene in Alzheimer's disease patients. Their findings were published in Aging Clin Exp Res. Bidwell J, Keen L, Gallagher G, et al. researched cytokine gene polymorphisms in human diseases and created an online database that was published in Genes Immun. Bruunsgaard H, Pedersen M, Pedersen BK conducted research on aging and proinflammatory cytokines, which was published in Curr Opin Hematol. Bidwell J, Keen L, Gallagher G, et al. conducted research on cytokine gene polymorphisms and their association with immunology and published their findings in Genes Immun. Andreotti F, Porto I, Crea F, Maseri A. reviewed population association studies on inflammatory gene polymorphisms and ischemic heart disease. Their findings were published in Heart. Stephens JW, Humphries SE investigated the molecular genetics of cardiovascular disease and published their findings in J Intern Med. Ershler WB, Keller ET studied age-associated increased gene expression, late-life diseases, and frailty and published their findings in Annu Rev. Ridker PM, Rifai N, Stampfer MJ, Hennekens CH studied the concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Their study was published in Circulation. Fernandez-Real JM, Broch M, Vendrell J, et al. researched the association between the interleukin-6 polymorphism and insulin sensitivity and published their findings in Diabetes. Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V investigated the association between inflammation, obesity, stress and coronary heart disease and published their findings in Atherosclerosis. Rauramaa R, Vaisanen SB, Luong LA et al. researched stromelysin-1 and interleukin-6 gene promoter polymorphisms as determinants of asymptomatic carotid artery atherosclerosis and published their findings in Arterioscler Vasc Biol. Vickers MA, Green FR, Terry C et al. investigated how genotype at a polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein and published their findings in Cardiovasc Res. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. researched interleukin-4 and the interleukin-4 receptor and published their findings in Annu Rev. Smith DA, Irving SD, Sheldon J, Cole D, Kaski JC. studied serum levels of the anti-inflammatory cytokine interleukin-10 in patients with unstable angina and published their findings in Circulation. Donger C, Georges JL, Nicaud V et al. studied new polymorphisms of the interleukin-6 gene and their relationship to myocardial infarction. Their findings were published in J Clin Invest. Koch W, Kastrati A, Bottiger C, Mehilli J, von Beckerath Schomig A. investigated interleukin-6 and tumor necrosis factor gene polymorphisms and their association with coronary artery disease and myocardial infarction. Their study was published in Atherosclerosis. Girndt M, Kaul H, Sester U et al. found that the anti-inflammatory interleukin-10 genotype protects dialysis patients from events and published their findings