p

and myocardial infarction is replicated in an Italian population. J Hum Genet

;

:

–

Helgadottir A, Thorleifsson G, Magnusson KP, Gre´tarsdottir S, Steinthorsdottir V, Manolescu A, Jones GT, Rinkel GJ, Blankensteijn JD, Ronkainen A, Ja¨a¨skela¨inen JE, Kyo Y, Lenk GM, Sakalihasan N, Kostulas K, Gottsa¨ter A, Flex A, Ste- fansson H, Hansen T, Andersen G, Weinsheimer S, Borch- Johnsen K, Jorgensen T, Shah SH, Quyyumi AA, Granger CB, Reilly MP, Austin H, Levey AI, Vaccarino V, Palsdottir E, Walters GB, Jonsdottir T, Snorradottir S, Magnusdottir D, Gudmundsson G, Ferrell RE, Sveinbjornsdottir S, Hernes- niemi J, Niemela¨ M, Limet R, Andersen K, Sigurdsson G, Benediktsson R, Verhoeven EL, Teijink JA, Grobbee DE, Rader DJ, Collier DA, Pedersen O, Pola R, Hillert J, Lindblad B, Valdimarsson EM, Magnadottir HB, Wijmenga C, Tromp G, Baas AF, Ruigrok YM, van Rij AM, Kuivaniemi H, Powell JT, Matthiasson SE, Gulcher JR, Thorgeirsson G, Kong A, Thorsteinsdottir U, Stefansson K. The same sequence variant on

p

associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet

;

:

–

Matarin M, Brown WM, Singleton A, Hardy JA, Meschia JF, ISGS investigators. Whole genome analyses suggest ischemic stroke and heart disease share an association with polymor- phisms on chromosome

p

Stroke

;

:

–

Emanuele E, Lista S, Ghidoni R, Binetti G, Cereda C, Benussi L, Maletta R, Bruni AC, Politi P. Chromosome

p

In conclusion, this study shows that the frequency of the C allele of rs1333049 was significantly lower in healthy cente- narians compared to young controls, whereas patients with precocious AMI showed a higher frequency. Our findings suggest that successful human aging is influenced by genetic factors influencing vascular-related events and dementia that each subject experiences as a part of a life-long, genetically determined trajectory of age-related disorders.

Author Disclosure Statement

All authors declare that no competing financial interests exist.

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