The current study strongly supports the association of APOE alleles with human longevity by demonstrating varia- tion in APOE allele frequencies in older persons and illus- trates the potential confounding effect of age in association studies on APOE. The underlying mechanism behind the association of APOE with age remains to be elucidated.

ACKNOWLEDGMENTS

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for Health Development, Tallinn, Estonia (Mati Rahu); Clin- ique Ophthalmologique, Universitaire de Creteil, Paris, France (Gisele Soubrane); Clinica Oculistica, Unversita` degli Studi di Verona, Verona, Italy (Laura Tomazzoli); Depart- ment of Ophthalmology, School of Medicine, Aristotle Uni- versity of Thessaloniki, Thessaloniki, Greece (Fotis Topouzis); Departamento Salud Publica, University Miguel Hernandez, Alicante, Spain (Jesus Vioque); Consorcio de Investigacio´n Biome´dica en Red Especializado en Epidemio- log´ıa y Salud Pu´blica (CIBERESP), Alicante, Spain (Jesus Vioque); and Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom (Astrid E. Fletcher).