Reaching extreme age without diseases is one aspect of successful aging [23]. In this study, elderly individuals with cardiovascular diseases, diabetes, or cognitive impairments were excluded from the current study. Previous studies have shown that SOD2-9T/C and MTHFR 677C/T polymorphisms were associated with diabetes, cancer, and cardiovascular diseases in other populations [9,10]. Thus, these polymorphisms might also associate with certain diseases in the Jordanian population. Exploring this possibility is a matter of future research.

Conclusion: In this study, we investigated the contribution of the SOD2-9T/C and MTHFR 677C/T gene polymorphisms to the longevity phenotype in the Jordanian population. The Mn-SOD -/- and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet. Van Remmen H, Ikeno Y, Hamilton M, Pahlavani M, Wolf N, Thorpe SR, Alderson NL, Baynes JW, Epstein CJ, Huang TT et al.: Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics. Doonan R, Malin JJ Muller F; Song X; van den Heuvel J; Hutter H; Kacheva S; Stelzer E; Nishimura K; van der Horst A, et al. Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on lifespan in Caenorhabditis elegans. Genes Dev. Paul A, Belton A, Nag S, Martin I, Grotewiel MS, Duttaroy A: Reduced mitochondrial SOD displays mortality characteristics reminiscent of natural aging. Mech Ageing Dev. Soerensen M, Christensen K, Stevnsner T, Christiansen L: The Mn-SOD single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old. Mech Ageing Dev. Dossey L: Longevity. Altern Ther Health Med. Deiana L, Ferrucci L, Pes GM, Carru C, Delitala G, Ganau A, Mariotti S, Nieddu A, Pettinato S, Putzu P et al.: AKEnnnos. The Sardinia Study ofThe link leads to the Biomed Central website's page on publishing advice. No changes needed.