Although the R allele has been credited with enhancing LDL oxidation and reducing HDL protective effect, it also produces higher levels of paraxonase activity in serum (Blatter Garin et al., 1994), the effect of which is largely unknown. Interestingly, Europeans tend to have a bimodal paraoxonase activity with high or low activity subjects and a preponderance of low activity subjects. Conversely, Asian and Oriental populations have a preponderance of high paraoxonase activity subjects (Gledmacher et al., 1988), and it is food for thought that Japan currently has the longest life expectancy in the world. Recently, Kuremoto et al. (2003) reported that the RR genotype of PON1 was more protective against lipoprotein oxidation and CHD in Japanese subjects.