[4] Tissenbaum HA, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature ; 410: 227-30.

[5] Chua KF,Mostoslavsky R, Lombard DB, Pang WW, Saito S, Franco S, et al. Mammalian SIRT1 limits replicative lifespan in response to chronic genotoxic stress. Cell Metab; 8:67-76 [1] Huang J, Gan Q, Han L, Li J, Zhang H, Sun Y, et al. SIRT1 overexpression antagonizes cellular senescence with activated ERK/Spk signaling in human diploid fibroblasts. PLoS ONE; 5:e10759 [2] Koo SH, Montminy M. In vino veritas: a tale of two sirtuins? Cell; 131:22-4 [3] Alcendor R, Gao S, Zhai P, Zablocki D, Holle E, Yu X, et al. SIRT1 regulates aging and resistance to oxidative stress in the heart. Circ Res; 100:1512-21 [4] Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, et al. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell; 135:907-18 [5] Mattson MP, Duan W, Guo Z. Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms. J Neurochem; 84:417-31 [6] Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science; 305:390-2 [7] Kuningas M, Putters M, Westendorp RGJ, Slagboom PE, van Heemst D. SIRT1 gene, age-related diseases, and mortality: the Leiden 85-plus study. J Gerontol A Biol Sci Med Sci; 62:960-5 [8] Zillikens MC, van Meurs JB, Sijbrands EJG, Rivadeneira F, Dehghan A, van Leeuwen JP, et al. SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin. Free Radic Biol Med; 50:124-31 [9] Flachsbart F, Croucher PJ, Nikolaus S, Hampe J, Cordesmeyer R, Schreiber S, et al. Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity. Exp Gerontol; 45:683-7 [10] Valdes AM, Andrew T, Gardner JP, Kimura M, Oelsner E, Cherkas LF, et al. Obesity, cigarette smoking, and telomere length in women. Lancet; 366:662-4 [11] http://www.scio.gov.cn/zfbps/ndhf/201108/Document/1123252/1123252.htm; [12] Bai B, Liang YC, Li YH, Shah XQ, Su XD, Li WW, et al. Evaluation of biological aging processes: a population-based study of healthy people in China. Gerontology; 56:513-20 [13] Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics; 21:263-5 [14] Helisalmi S, Vepsäläinen S, Hiltunen M, Koivisto AM, Salminen A, Laakso M, et al. Genetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease. J Neurol; 256:702-6 [15] Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory; 1989. [16] Raymond M, Rousset F. GENEPOP (Version 1.2): population genetics software for exact tests and ecumenicism. J Hered; 86:248-9 [17] Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet; 68:978-89 [18] Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science; 303:Ravussin E. Calorie restriction and aging: review of the literature and implications for studies in humans. Am J Clin Nutr;  :    [  ]
Cru, Valladare, Algad, Garcia, Ros, Edwards, Angele Martinez J, et al. Candidate gene association study conditioning on individual ancestry in patients with type diabetes and metabolic syndrome from Mexico City. Diabetes Metab Res Rev;  :      [  ]
Salminen A, Kauppinen A, Suuronen T, Kaarniranta K. SIRT longevity suppresses NF-kappa-driven immune responses: regulation of aging via kappa acetylation? Bioessays;  :    [  ]
Salminen A, Kaarniranta K. SIRT: regulation of longevity via autophagy. Signal;  :    [  ]
Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, et al. Resveratrol improves mitochondrial function and protects against disease by activating SIRT and PGC-alpha. Cell;  :    [  ]
Chen D, Steele AD, Lindquist S, Guarente L. Increase in activity during restriction requires SIRT. Science;  :  [  ]
Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado De R et al. SIRT promotes fat mobilization in white adipocytes by repressing gamma. Nature;  :