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CONFLICT OF INTEREST

The authors declare no conflict of interest.

ACKNOWLEDGEMENTS

study was supported by the Max-Planck Institute for Demographic (Rostock, Germany), the INTERREG 4 A programme Syddanmark– (by EU funds from the European Regional Development the European Union’s Seventh Framework Programme (FP7/2007–2011)

This study was supported by the Max-Planck Institute for Demographic Research, (Rostock, Germany), the INTERREG 4 A programme Syddanmark– Schleswig-K.E.R.N (by EU funds from the European Regional Development Fund), the European Union’s Seventh Framework Programme (FP7/2007–2011) under grant agreement no. 259679, the National Institute on Aging (P01 AG08761), the RESOLVE project (FP7-HEALTH-F4-2008-202047) and the Novo Nordisk, the Aase and Ejnar Danielsen, the Brødrene Hartmann, the King Christian the 10th and the Einer Willumsens Mindelegat Foundations. The Danish Aging Research Center is supported by a grant from the VELUX Foundation, while Mette Soerensen is supported by an individual postdoctoral grant from The Danish Council for Independent Research – Medical Sciences.

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Supplementary Information accompanies this paper on European Journal of Human Genetics website (http://www.nature.com/ejhg)