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Table 1. Anthropometric and metabolic characteristics of the study cohort stratified according to

Table 1. Anthropometric and metabolic characteristics of the study cohort stratified according to

Table 2. Results of robust association tests between SDC4 SNPs and longevity

SNP MAF Z1.add Z.rec Z.dom P2.add P.rec P.dom Theop3 rs2228384 0.38 (C) 1.821 1.276 1.634 0.069 0.202 0.102 0.140 rs2072785 0.40 (T) 1.270 -0.041 1.881 0.204 0.967 0.060 0.124 rs1981429 0.44 (G) -1.385 -2.495 0.018 0.166 0.013 0.986 0.028 rs2267871 0.30 (T) -1.761 -0.589 -2.055 0.078 0.556 0.040 0.082 rs2251252 0.47 (A) 2.245 0.950 2.663 0.025 0.342 0.008 0.018 rs2284277 0.21 (A) -0.530 -0.412 -0.457 0.596 0.680 0.648 0.836 rs6130811 0.31 (G) 2.456 0.994 2.609 0.014 0.320 0.009 0.020 rs2070639 0.49 (T) -1.630 -1.443 -1.209 0.103 0.149 0.227 0.203 rs4599 0.21 (G) -0.690 0.328 -0.985 0.490 0.743 0.325 0.545 rs749111 0.16 (T) -0.854 -0.744 -0.712 0.393 0.457 0.477 0.630 rs11697824 0.16 (A) -0.580 -0.073 -0.644 0.562 0.942 0.519 0.769

1Z-score represents the z-statistics under the additive, recessive and dominant models. 2p-value calculated for each genetic model. 3Theoprefers to the p-value adjusted for multiple comparisons (due to the three different genetic models). In bold, p-value significant after adjusting for multiple comparisons.

bold, p-value significant after adjusting for multiple comparisons. Minor Allele Frequency in our control group.

SNPs rs2228384 rs1981429 Freqa Score P-valueb T G 0.41452 -2.42697 0.01523 T T 0.18413 0.97116 0.33147 C G 0.01198 1.00192 0.31638 C T 0.38937 1.44286 0.14906

4. Results of the RobustSNP association test with the hematological variables (total triglyceride, HDL cholesterol, LDL cholesterol, Fasting glucose and Hemoglobin in the control group.

SNP Z1.add Z.rec Z.dom P2.add P.rec P.dom Theop3 Total cholesterol rs1981429 -1.496 -0.315 -2.091 0.135 0.753 0.036 0.077 rs2251252 1.043 1.948 -0.029 0.297 0.051 0.977 0.108 rs6130811 1.148 1.612 0.566 0.251 0.107 0.572 0.212 Triglyceride rs1981429 2.251 1.779 2.168 0.024 0.075 0.030 0.049 rs2251252 -1.238 -0.716 -1.291 0.216 0.474 0.197 0.356 rs6130811 -1.167 -1.862 -0.659 0.243 0.063 0.510 0.129 HDL cholesterol rs1981429 -0.451 0.461 -1.087 0.652 0.645 0.277 0.463 rs2251252 0.479 0.429 0.372 0.632 0.668 0.710 0.859 rs6130811 0.665 0.709 0.463 0.506 0.478 0.643 0.715 LDL cholesterol rs1981429 -2.318 -1.226 -2.626 0.020 0.220 0.009 0.020 rs2251252 1.397 2.288 0.241 0.162 0.022 0.809 0.049 rs6130811 1.369 1.981 0.675 0.171 0.048 0.499 0.101 Fasting glucose rs1981429 -0.306 -0.098 -0.382 0.760 0.922 0.703 0.907 rs2251252 0.064 0.994 -0.909 0.949 0.320 0.363 0.528 rs6130811 0.294 0.877 -0.400 0.769 0.381 0.689 0.603

Triglyceride

Fasting glucose

Hemoglobin A1c rs1981429 -0.198 -0.190 -0.140 0.843 0.849 0.889 0.975 rs2251252 -0.728 0.524 -1.446 0.467 0.600 0.148 0.274 rs6130811 -0.008 0.855 -0.748 0.993 0.392 0.455 0.614

represents the z-statistics under the additive, recessive and dominant models. 2p-value calculated for each genetic model. 3Theoprefers to the p-value adjusted for multiple comparisons (due to the three different genetic models). In bold, p-value significant after adjusting for multiple comparisons.