received support under a grant (AG1764406S1) awarded by the National Institute on Aging (NIA). ELSA was developed by a team of researchers based at the National Centre for Social Research, University College London and the Institute of Fiscal Studies. The data were collected by the National Centre for Social Research. Religious Order Study: Grants P30AG10161, R01AG15819, and R01AG30146 from the National Institute on Aging, and the Translation Genomics Research Institute. Memory and Aging Project: Grants R01AG17917 and R01AG15819 from the National Institute on Aging, and the Translation Genomics Research Institute. The Longevity Consortium, funded by the National Institute of Aging, grant number U19 AG023122, provided administrative resources to CHARGE investigators for this phenotype as well as scientific opportunity funds for de novo genotyping of the 5 selected SNPs in the ELSA and Whitehall II replication studies. Acknowledgements Rotterdam Study: The Rotterdam Study is supported by Netherlands Genomics Initiative/Netherlands Consortium for Healthy Aging (050-060-810); Netherlands Organisation for Scientific Research (NWO) (904-61-090, 904-61-193, 480-04-004, 400-05-717, SPI 56-464-1419, 175.010.2005.011, 911-03-012 and 017.106.370); NetsparLiving longer for a good health; the Erasmus Medical Center, and Erasmus University in Rotterdam; the Netherlands Organisation for Health Research and Development, the Netherlands Research Institute for Diseases in the Elderly; the Dutch Ministry of Education, Culture and Science, and the Ministry for Health, Welfare and Sports; the European Commission; and the Municipality of Rotterdam, the Netherlands. Atherosclerosis Risk in Communities Study: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, and N01-HC-55022. The authors thank the staff and participants of the ARIC study for their important contributions. Age, Gene/Environment Susceptibility-Reykjavik Study: The Age, Gene/Environment Susceptibility-Reykjavik Study is funded by NIH contract N01-AG-12100, the NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association), and the Althingi (the Icelandic Parliament). Genotyping was conducted at the NIA IRP Laboratory of Neurogenetics. Cardiovascular Health Study: The CHS research reported in this article was supported by contract numbers N01-HC-85079 through N01-HC-85086, N01 HC-35129, N01 HC-15103, N01 HC-55222, N01-HC-75150, N01-HC-45133, grant numbers U01 HL080295 and R01 HL087652 from the National Heart, Lung, and Blood Institute. Invecchiare nel Chianti: The InCHIANTI study baseline (1998-2000) was supported as a targeted project (ICS110.1/RF97.71) by the Italian Ministry of Health and in part by the U.S. National Institute on Aging (Contracts: 263 MD 9164 and 263 MD 821336). Brack, A.S., Conboy, M.J., Roy, S., Lee, M., Kuo, C.J., Keller, C., Rando, T.A., 2007. Increased Wnt signaling during aging alters muscle stem T.A., Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science, Bradley, S.V., Holland, E.C., Liu, G.Y., Thomas, D., Hyun, T.S., Ross, T.S., Huntingtin interacting protein is a novel brain tumor marker that associates with epidermal growth factor receptor. 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