:

–

Leibiger IB, Berggren PO (

) Sirt

: a metabolic master switch that modulates lifespan. Nat Med

:

–

Liang F, Kume S, Koya D (

) SIRT

and insulin resistance. Nat Rev Endocrinol

:

–

Li Y, Xu S, Giles A, Nakamura K, Lee JW, et al. (

) Hepatic overexpression of SIRT

in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB J

:

–

Feige JN, Lagouge M, Canto C, Strehle A, Houten SM, et al. (

) Specific SIRT

activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab

:

–

Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, et al. (

) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT

and PGC-

alpha. Cell

:

–

Bluher M, Kahn BB, Kahn CR (

) Extended longevity in mice lacking the insulin receptor in adipose tissue. Science

:

–

Boily G, Seifert EL, Bevilacqua L, He XH, Sabourin G, et al. (

) Si

regulates energy metabolism and response to caloric restriction in mice. PL

One

: e

Clark SJ, Falchi M, Olsson B, Jacobson P, Cauchi S, et al. (

) Association of Sirtuin

(SIRT

) Gene SNPs and Transcript Expression Levels With Severe Obesity. Obesity (Silver Spring)

:

–

Peeters AV, Beckers S, Verrijken A, Mertens I, Roevens P, et al. (

) Association of SIRT

gene variation with visceral obesity. Hum Genet

:

–

Zheng J, Chen LL, Xiao F, Hu X, Deng X, et al. (

) Three single nucleotide variants of the SIRT

gene are associated with overweight in a Chinese population: a case control study. Endocr J

:

–

Zillikens MC, van Meurs JB, Rivadeneira F, Amin N, Hofman A, et al. (

) SIRT

genetic variation is related to BMI and risk of obesity. Diabetes

:

–

Dong Y, Guo T, Traurig M, Mason CC, Kobes S, et al. (

) SIRT

is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type

diabetes in Pima Indians. Mol Genet Metab

:

–

Shimoyama Y, Suzuki K, Hamajima N, Niwa T (

) Sirtuin

gene polymorphisms are associated with body fat and blood pressure in Japanese. Transl Res

:

–

Weyrich P, Machicao F, Reinhardt J, Machann J, Schick F, et al. (

) SIRT

genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention--the TULIP Study. BMC Med Genet

:

Botden IP, Zillikens MC, de Rooij SR, Langendonk JG, Danser AH, et al. (

) Variants in the SIRT

gene may affect diabetes risk in interaction with prenatal exposure to famine. Diabetes Care

:

–

Flachsbart F, Croucher PJ, Nikolaus S, Hampe J, Cordes C, et al. (

) Sirtuin

(SIRT

) sequence variation is not associated with exceptional human longevity. Exp Gerontol

:

–

Kuningas M, Putters M, Westendorp RG, Slagboom PE, van Heemst D (

) SIRT

gene, age-related diseases, and mortality: the Leiden

-plus study. J Gerontol A Biol Sci Med Sci

:

–

Willcox BJ, Donlon TA, He Q, Chen R, Grove JS, et al. (

) FOXO

A genotype is strongly associated with human longevity. Proc Natl Acad Sci U S A

:

–

Zillikens MC, van Meurs JB, Sijbrands EJ, Rivadeneira F, Dehghan A, et al. (

) SIRT

genetic variation and mortality in type

diabetes: interaction with smoking and dietary niacin. Free Radic Biol Med

:

–

Herskind AM, M

ue M, Holm NV, Sorensen TI, Harvald B, et al. (

) The heritability of human longevity: a population-based study of

Danish twin pairs born

–

Hum Genet

:

–

Houtkooper RH, Pirinen E, Auwerx J (

) Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol

:

–

van Diemen CC, Postma DS, Vonk JM, Bruinenberg M, Schouten JP, et al. (

) A disintegrin and metalloprotease

polymorphisms and lung function decline in the general population. Am J Respir Crit Care Med

:

–

Siedlinski M, Boer JM, Smit HA, Postma DS, Boezen HM (

) Dietary factors and lung function in the general population: wine and resveratrol intake. Eur Respir

:

–

Guarente L (

) Franklin H. Epstein Lecture: Sirtuins, aging, and medicine. N Engl J Med

:

–

Chua KF, Mostoslavsky R, Lombard DB, Pang WW, Saito S, et al. (

) Mammalian SIRT

limits replicative life span in response to chronic genotoxic stress. Cell Metab

:

–

Zhang WG, Bai XJ, Chen XM (

) SIRT

variants are associated with aging in a healthy Han Chinese population. Clin Chim Acta

:

–

Bordone L, Cohen D, Robinson A, Motta MC, van Veen E, et al. (

) SIRT

transgenic mice show phenotypes resembling calorie restriction. Aging Cell

:

–

Moynihan KA, Grimm AA, Plueger MM, Bernal-Mizrachi E, Ford E, et al. (

) Increased dosage of mammalian Sir

in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metab

:

–

Baur JA, Ungvari Z, Minor RK, Le Couteur DG, de Cabo R (

) Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov

:

–

Yang TP, Beazley C, Montgomery SB, Dimas AS, Gutierrez-Arcelus M, et al. (

) Genevar: a database and Java application for the analysis and visualization of SNP-gene associations in

TL studies. Bioinformatics

: