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Fig. 2. Protein structural modeling of the PMS2 nsSNP (p.Y318C) associated with longevity. The location of mutated amino acid in the PMS2 is indicated as red spheres in the crystallographic structure of PMS2 (Guarne et al., 2001). Arrows indicate the location of the novel nsSNP identified in centenarians. Blue indicates the bound AMPPNP, marking the ATPase active site.

discover functional regulatory variants (Wray, 2007) of our candidate genes associated with longevity and to investigate the molecular mechanisms underlying the association in future studies.

Acknowledgments

We would like to thank Genomics Shared Facility at Albert Einstein College of Medicine for their assistance with the iPLEX MassArray assay. This work was funded by NIH grant AG024391, AG027734, and AG17242. YS is the recipient of a Glenn Award for Research in Biological Mechanisms of Aging.