2013 The Authors Aging Cell © 2013 Blackwell Publishing Ltd/Anatomical Society of Great and Ireland

Start SNP Rs10484218 Rs2429990 Rs432001 Rs7250748 End SNP Rs977870 Rs1294791 Rs919333 Rs10403760 0 NPL 3.47 2.95 3.76 3.57 NPL_subsets* 3.15 3.26 3.85 3.80 Weighted_NPL_subsets** 2.69 3.71 2.96 1.85 1According to genome build 35

8p11.21- 15q12-q14 19q13.33- q13.1 q13.41 Sex Men Women Women 1 1 1 1LOD-drop interval 64-82 cM 14-28 cM 66-90 cM Start SNP Rs801100 Rs1871009 Rs1236093 End SNP Rs4368961 Rs580839 Rs1661965

NPL 1.14 0.62 4.97 NPL_subsets* 1.96 1.44 3.92 Weighted_NPL_subsets** 3.61 3.16 3.60 1According to genome build 35

2013 The Authors Aging Cell © 2013 Blackwell Publishing Ltd/Anatomical Society of Great and Ireland

Fig. 4 Genome wide linkage graphs of among 1145 female-only sibships and 263 male-only sibships of

C1 vs C2 -0.06-                    # Odensem TampereA BelfastBNewcastLeiden@ Louvainww Kiel= Montpe!Cluster 30.0330.043;0.053Cluster 1

Denmark, The Netherlands, United Kingdom, Belgium and France ; Cluster 3:

2013 The Authors Aging Cell © 2013 Blackwell Publishing Ltd/Anatomical Society of Great and Ireland

NPL LOD scores and the yellow line the age-weighted LOD scores.   ri " Ad i !|T15|  

  |Jnl|Ne  

2013 The Authors Aging Cell © 2013 Blackwell Publishing Ltd/Anatomical Society of Great and Ireland

lod scorelod scoreChromosome 1420 30 40position in cM50~°2Boa22°60 40Chromosome 1960Chromosome 1780 100 120 140position in cM position in cM— NPL all clusters= weigthed with age (all clusters) 

2013 The Authors Aging Cell © 2013 Blackwell Publishing Ltd/Anatomical Society of Great and Ireland

Fig. 4 Genome wide linkage graphs of among 263 male-only sibships and 1145 female-only sibships of the GEHA study. © 2013 The Authors Aging Cell © 2013 Blackwell Publishing Ltd/Anatomical Society of Great LOD score      romosome 

2013 The Authors Aging Cell © 2013 Blackwell Publishing Ltd/Anatomical Society of Great and Ireland