(A) Case–control study (initial findings) Longitudinal study (similar directions of effects) Number-of-days-lived variable Pathway Gene SNP OR β-coef. 95% CI P-value GH/IGF-1/INS INS rs3842755 1.789 2.73♂ 0.66–4.80♂ 0.01♂ IGF2R rs9456497 1.424 2.77♂ −0.01–5.56♂ 0.05♂ DNA repair WRN rs13251813 1.840 2.23 0.31–4.15 0.02 Early/late death variable Pathway Gene SNP OR OR 95% CI P-value DNA repair RAD52 rs11571461 2.226 1.30♀ 0.96–1.78♀ 0.10♀ NTHL1 rs3211994 1.994♂ 1.42 1.09–1.86 0.009 (B) Longitudinal study (initial findings) Case–control study (similar direction of effect) Number-of-days-lived variable Pathway Gene SNP β-coef. OR 95% CI PCCA Pro/antioxidants XDH rs207444 4.043 1.42 1.10–1.83 0.005

Notes: OR: odds ratio, β-coef: beta coefficient, 96% CI: 95% confidence interval, ♂: males separately, ♀: females separately, PCCA: allelic case–control comparison P-value.

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