,

–

Huang,T.T.,Raineri,I.,Eggerding,F.,Epstein,C.J.,

Transgenicandmutantmice for oxygen free radical studies. Methods Enzymol.

,

–

Lastly, other SNPs may be in linkage to the SNPs investigated here, and other SNPs (in genes protecting against ROS) are expected to contribute to the variation in aging and longevity. Therefore, we continue our search of SNPs in such genes and their possible association with aging and longevity.

Acknowledgements

This study was financially supported by the National Institute on Aging (P01 AG08761-18). The Danish Aging Research Center is supported by a grant from the VELUX Foundation (95-103-11419).

References

Ambrosone,C.B.,Freudenheim,J.L.,Thompson,P.A.,Bowman,E.,Vena,J.E.,Marshall, J.R., Graham, S., Laughlin, R., Nemoto, T., Shields, P.G., 1999. Manganese super- oxide dismutase (MnSOD) genetic polymorphisms, dietary antioxidants, and

Ambrosone,C.B.,Freudenheim,J.L.,Thompson,P.A.,Bowman,E.,Vena,J.E.,Marshall, J.R., Graham, S., Laughlin, R., Nemoto, T., Shields, P.G.,

Manganese super- oxide dismutase (M

OD) genetic polymorphisms, dietary antioxidants, and risk of breast cancer. Cancer Res.

,

–

Andersen,H.R.,Jeune,B.,Nybo,H.,Nielsen,J.B.,Andersen-Ranberg,K.,Grandjean,P.,

Low activity of superoxide dismutase and high activity of glutathione reductase in erythrocytes from centenarians. Age Ageing

,

–

Antonella, B., Claudio, C., Anna, C., Palmira, B., Salvatore, C., Roberto, F.,

Oxidative stress and ventricular dysfunction in ischemic heart disease. Heart Fail. Rev.

(

),

–

Bastaki, M., Huen, K., Manzanillo, P., Chande, N., Chen, C., Balmes, J.R., Tager, I.B., Holland,N.,

Genotype-activityrelationshipfo

n-superoxidedismutase,

and Development

(

)

–

Slot, J.W., Geuze, H.J., Freeman, B.A., Crapo, J.D.,

Intracellular localization the copper-zinc and manganese superoxide dismutases in rat liver mal cells. Lab. Invest.

,

–

Stessman, J., Maaravi, Y., Hammerman-Rozenberg, R., Cohen, A., Nemanov, Gritsenko, I., Gruberman, N., Ebstein, R.P.,

Candidate genes with ageing and life expectancy in the Jerusalem longitudinal study. Ageing Dev.

,

–

Stoehlmacher, J., Ingles, S.A., Park, D.J., Zhang, W., Lenz, H.J.,

The polymorphism in the mitochondrial targeting sequence of the superoxide dismutase gene (M

OD) is associated with age among with colorectal carcinoma. Oncol. Rep.

,

–

Sun, J., Folk, D., Bradley, T.J., Tower, J.,

Induced overexpression of drial Mn-superoxide dismutase extends the life span of adult melanogaster. Genetics

,

–

Sutton, A., Khoury, H., Prip-Buus, C., Cepanec, C., Pessayre, D., Degoul, F.,

Ala

Val genetic dimorphism modulates the import of human superoxide dismutase into rat liver mitochondria. Pharmacogenetics

–

The manganese superoxide dismutase Ala

Val dimorphism both mitochondrial import and

NA stability. Pharmacogenet. Genomics

–

Tang, N.P., Wang, L.S., Yang, L., Gu, H.J., Sun, Q.M., Cong, R.H., Zhou, B., Zhu, Wang, B.,

Genetic variant in glutathione peroxidase

gene is with an increased risk of coronary artery disease in a Chinese population. Chim. Acta

,

–

Taufer, M., Peres, A., de, A.V., de, O.G., Sa, G., do Canto, M.E., dos Santos, A.R., M.E., da, C.I.,

Is the Val

Ala manganese superoxide dismutase morphism associated with the aging process? J. Gerontol. A Biol. Sci. Med.

,

–

Valko, M., Izakovic, M., Mazur, M., Rhodes, C.J., Telser, J.,

Role of radicals in DNA damage and cancer incidence. Mol. Cell Biochem.

, Van Landeghem, G.F., Tabatabaie, P., Beckman, G., Beckman, L., Andersen,

Manganese-containing superoxide dismutase signal sequence morphism associated with sporadic motor neuron disease. Eur. J. Neurol.

–

Van Remmen, H., Ikeno, Y., Hamilton, M., Pahlavani, M., Wolf, N., Thorpe, Alderson, N.L., Baynes, J.W., Epstein, C.J., Huang, T.T., Nelson, J., Strong, Richardson, A.,

Life-long reductioni

OD activityresultsin DNA damage and higher incidence of cancer but does not accelerate Physiol. Genomics

,

–

Van Remmen, H., Qi, W., Sabia, M., Freeman, G., Estlack, L., Yang, H., Mao, Huang, T.T., Strong, R., Lee, S., Epstein, C.J., Richardson, A.,

deficiencies in antioxidant enzymes in mice result in a compound in sensitivity to oxidative stress. Free Radic. Biol. Med.

,

–

Vijg, J.,

Somatic mutations and aging: a re-evaluation. Mutat. Res.

,

Wang, L.I., Miller, D.P., Sai, Y., Liu, G., Su, L., Wain, J.C., Lynch, T.J., Christiani,

Manganese superoxide dismutase alanine-to-valine polymorphism codon

and lung cancer risk. J. Natl. Cancer Inst.

,

–

Wiener, H.W., Perry, R.T., Chen, Z., Harrell, L.E., Go, R.C.,

A polymorphism SOD

is associated with development of Alzheimer’s disease. Genes Behav.

,

–

Woodson, K., Tangrea, J.A., Lehman, T.A., Modali, R., Taylor, K.M., Snyder, K., P.R., Virtamo, J., Albanes, D.,

Manganese superoxide dismutase polymorphism, alpha-tocopherol supplementation and prostate cancer risk the alpha-tocopherol, beta-carotene cancer prevention study (Finland). Causes Control

,

–

Ichimura, Y., Habuchi, T., Tsuchiya, N., Wang, L., Oyama, C., Sato, K., Nishiyama, H., Ogawa, O., Kato, T.,

Increased risk of bladder cancer associated with a glutathione peroxidase

codon

variant. J. Urol.

,

–

Kakko, S., Paivansalo, M., Koistinen, P., Kesaniemi, Y.A., Kinnula, V.L., Savolainen, M.J.,

The signalsequence polymorphismofthe M

OD geneisassociated with the degree of carotid atherosclerosis. Atherosclerosis

,

–

Kuzuya, M., Ando, F., Iguchi, A., Shimokata, H.,

Glutathione peroxidase

Pro

Leu variant contributes to the metabolic syndrome in men in a large Japanese cohort. Am. J. Clin. Nutr.

,

–

Lebovitz, R.M., Zhang, H., Vogel, H., Cartwright Jr., J., Dionne, L., Lu, N., Huang, S., Matzuk, M.M.,

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc. Natl. Acad. Sci. USA

,

–