Using case/control and relative-risk approaches  clear sex-dependent association ~~ eeebetween | | human longevity | and | | as marker “eeelocalized inside’ the ' TH. sreegene | 6(cid:22)E#(cid:20)(cid:22)0(cid:31)7 ) had been | observed 6$(cid:2) ‘omnes y eeeBenedictis et (cid:17)(cid:10)!& (cid:31)3321 Tan et (cid:17)(cid:10)!& (cid:30)00(cid:31)7! mn —)In the yr eeepresent ana EO”study, we examined two Stiadditional ((cid:29)%9 me RRR A A Amarkers, o> =” en,which lie in 2the ye”INS | and a eeeIGF2 genes mee yOlocated downstream ‘ | TH « fon 11p1s ! . chromosome, | in | order 1 “£0 ( y continue | the « —_——_—— = Eee- exploration « (cid:11)* "such 1 an intriguing ee EEE IEE EE, chromosomal 1 | region. ] . Neither | mag anerINS 1 nor | t IGF2 1 . markers ¢ s did 1 “spo| reveal « | association \ 1 with DEN EEE ES ™longevity. ’ . This 1 ; may | be « “ENSdue « — nseither | “tot ) the | fact | | that t t these | loci « | do 1 ) not affect | | human | | longevity ort r to t pwnd) the { “ye ne> fact t t that t eet the ¢ > diallelic 1 > markers s used i lint 1 the ¢ > analysis < 5 are 1 > not z t able t > tol ) reveal ¢ ee NEN EES| association 6$(cid:2) : Benedictis | et (cid:17)(cid:10)!& (cid:31)33A7! The : : second |   “see; seems | to | be 1 more | likely, | _ taking | - into Aereo—eor—account the data in imodel fe he eeeorganisms ee DSwhich show the pivotal roles ENE DDplayed in eee eeelifespan extension by IED IL ID IL IEDE ED IA ELLISmetabolic-pathways controlling genes. retusa *Indeed, Je peelinkage FE EE OEEdisequilibrium analyses | a Peetrongly |  eeindicate | reethat | the « entire 1 LOregion | eee| considered | here is | ——oNe; involved | mTin | oo"| the | long- eee)evity | yee I OD' phenotype. J eee_ Consider - the | : sex-specific | oe eeefindings « ; obtained | | by « - case/control « IE IN EIEIO| comparisons wre) resrelevant t { to oD eee» TH-INS « > and * | TH-IGF2 | Sehaplotypes. " eee. The s NN LLB> significant « “72 ee eet difference { » found i lin { pe ee eee1 females but 1 Not | ins males | for’ -TH-INS | ee eeallelic ; pe’ J Pes * aNassociations | oe| (Table - D7 ) suggests | that | - female-specific longevity - factors | ; are | enclosed : | in| the ' - TH-INS | weave  <(cid:12) the | fooNNeeother | hand, | the : “Ne eeesignificant aM NaS TD”difference - found | | in males | but | not) in: | females | for’ ~ooe ee» TH-IGF2 | allelic | DONE NRE ROS- associations | en NN(Table | @7 indicates | that 1 male-specific - longevity | factors ; are | - enclosed | | in | | the ' » TH-IGF2 | Nn Neregion. | MSSuch

increased 1 | metabolic | an =)rate Seeand ;  “pee| higher | level « (cid:11)* ‘ sympathetic | nervous : eee; system ; | activity when compared | | with « | elderly | women | AN Eee ee| (Poehlman | et i (cid:17)(cid:10)!& (cid:31)33A7! The : strong | DN ONEdifferences | mJ oo- observed eee eebetween | | male ; and | ees PEM| female | NOE NI NID DIE- centenarians | for | both ' ot rn a. TH-INS | and ' ee SO| TH-IGF2 | systems | ; may | be the « > consequence ¢ (cid:11)* f sex-specific : - survival { | factors ; spanning t r the « - entire > 11p1s ! NED IESE OI) chromosomal region | oehere. - considered.   “re.In| any | case, the | results ; “reeare |   MoMline | with» aN AAOfindings | | observed | | in the ooomodel s | system J | Drosoph hila 1 BO OEE ORONO1 melanogaster \ - where s > sex-specific « NEE LLL: quantitative t - trait | t loci é i affecting DELILE OTlongevity | have | OTP- been | POE EE OOS| shown | OO IEIEIEID EIS| (Nuzhdin « et | (cid:17)(cid:10)!& (cid:31)33A7!