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The effect of Apo E polymorphism on plasma total Cholesterol, LDL-Cholesterol, and Apo B values (adjusted for sex and age) was evaluated by analysis of covariance [Table 4]. The numbers of 3 and 4 alleles were introduced as explanatory variables. Since the number of the three possible alleles in the genotype is not independent, the effect of more than two cannot be evaluated simultaneously. A significant association was observed between 4 and all the lipid parameters, whereas 3 was significantly associated with LDL-Cholesterol only and more weakly with the other parameters.

Age ≤65 66-70 71-75 >76 p * N=165 N=32 NAt the Apolipoprotein E locus, in relation to the risk of coronary disease. Clin. Genet. : -, Cauley JA, Eichner JE, Kamboh MI, Ferrell RE, Kuller LH: Apo E allele frequencies in younger (age - ) vs older (age - ) women. Genet. Epidemiol. : -, Eggertsen G., Tegelman R., Ericsson S., Angelin B., Berglund L.: Apolipoprotein E polymorphism in a healthy Swedish population: variation of allele frequency with age and relation to serum lipid concentrations. Clin. Chem. : -, Davignon J., Bouthillier D., Nestruck AC, Sing CF: Apolipoprotein E polymorphism and atherosclerosis: from a study in octogenarians. Trans. Am. Clin. Climatol. Assoc. : -, Eto M., Watanabe K., Ishima Y., Morikawa A, Oshima-Sekiguchi M., Ishii K.: Apolipoprotein E phenotypes and plasma lipids in young and middle-aged subjects. Tohoku J. Exp. Med.: -, Warnick GR, Albers JJ: A comprehensive evaluation of the heparin-manganese precipitation procedure for high-density lipoprotein cholesterol. J. Lipid Res.: -, Friedewald WT, Levy RI, Frederickson DS: Estimation of the concentration of low-density lipoprotein cholesterol plasma without the use of the preparative ultracentrifuge. Clin. Chem.: -.