Furthermore, we undertook a meta-analysis to explore the significance of the rs2802292 association with longevity byThe text appears to be a mix of random characters, numbers, and scientific jargon. It is difficult to understand the context or intended message. Please provide the original text or a brief summary of the topic to assist in processing.The FOXO3A gene SNP rs2802292, or SNPs in LD, have a protective role by partially increasing the ability of other proteins to activate FOXO3A, or by increasing FOXO3A activity on downstream targets. Resequencing of the FOXO3A locus will clarify the nature of the genetic variation that is tracked by rs2802292. It is possible that the variation does not need to affect coding genes because coding genes are less than one-third of the evolutionarily conserved genome. Furthermore, future population studies on diseases of aging will clarify if FOXO3A associates across diseases, like the longevity gene APOE and Alzheimer's and cardiovascular diseases. From the data obtained in our population, meta-analysis represents a well-established method for summarizing results and drawing conclusions from different studies for a set of common hypotheses. Therefore, we applied this approach to combine our association results for the SNP rs2802292 with the findings coming from Willcox et al.'s study and to achieve more statistical power. The null significance of the Q-statistics (p<0.88) and the inconsistency indicates that the association is strictly linked with male gender. Taking this new evidence into consideration, we suggest a gender-specific analysis for the longevity phenotype. To conclude, the discovery and replication of a convincing association of FOXO3A locus contributes to the hypothesis that the impact of the IGF-I insulin pathway on longevity is a property that has been evolutionarily conserved throughout the animal kingdom.

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