a) Association of the ER

/

EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men. Am J Med

:

–

van Rossum EF, Koper JW, Huizenga NA, Uitterlinden AG, Janssen JA, Brinkmann AO, Grobbee DE, de Jong FH, van Duyn CM, Pols HA, Lamberts SW (

) A poly- morphism in the glucocorticoid receptor gene, which de- creases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels. Dia- betes

:

–

van Rossum EF, Koper JW, Van Den Beld AW, Uitterlinden AG, Arp P, Ester W, Janssen JA, Brinkmann AO, de Jong FH, Grobbee DE, Pols HA, Lamberts SW (

) Identi- fication of the Bc

polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocor- ticoids in vivo and body mass index. Clin Endocrinol (Oxf)

:

–

van Rossum EF, Voorhoeve PG, te Velde SJ, Koper JW, Delemarre-van de Waal HA, Kemper HC, Lamberts SW (

b) The ER

/

EK polymorphism in the glucocor- ticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults. J Clin Endocrinol Metab

:

–

Weverling-Rijnsburger AW, Blauw GJ, Lagaay AM, Knook DL, Meinders AE, Westendorp RG (

) Total choles- terol and risk of mortality in the oldest old. Lancet

:

–

Weverling-Rijnsburger AW, Jonkers IJ, van Exel E, Gussekloo J, Westendorp RG (

) High-density vs low-density lipo- protein cholesterol as the risk factor for coronary artery dis- ease and stroke in old age. Arch Intern Med

:

–

de Kloet ER, Vreugdenhil E, Oitzl MS, Joels M (

) Brain corticosteroid receptor balance in health and disease. Endocr Rev

:

–

de Lange P, Koper JW, Huizenga NA, Brinkmann AO, de Jong FH, Karl M, Chrousos GP, Lamberts SW (

) Differ- ential hormone-dependent transcriptional activation and - repression by naturally occurring human glucocorticoid receptor variants. Mol Endocrinol

:

–

Di Blasio AM, van Rossum EF, Maestrini S, Berselli ME, Tagliaferri M, Podesta F, Koper JW, Liuzzi A, Lamberts SW (

) The relation between two polymorphisms in the glucocorticoid receptor gene and body mass index, blood pressure and cholesterol in obese patients. Clin Endocrinol (Oxf)

:

–

Dobson MG, Redfern CP, Unwin N, Weaver JU (

) The N

S polymorphism of the glucocorticoid receptor: po- tential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus. J Clin Endocrinol Metab

:

–

Echwald SM, Sorensen TI, Andersen T, Pedersen O (

) The Asn

Ser variant of the glucocorticoid receptor gene is not associated with obesity or weight gain in Danish men. Int J Obes Relat Metab Disord

:

–

Friedewald WT, Levy RI, Fredrickson DS (

) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem

:

–

Heijmans BT, Gussekloo J, Kluft C, Droog S, Lagaay AM, Knook DL, Westendorp RG, Slagboom EP (

) Mor- tality risk in men is associated with a common mutation in the methylene-tetrahydrofolate reductase gene (MTHFR). Eur J Hum Genet

:

–

Huizenga NA, Koper JW, de Lange P, Pols HA, Stolk RP, Burger H, Grobbee DE, Brinkmann AO, de Jong FH, Lamberts SW (

a) A polymorphism in the glucocor- ticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo. J Clin Endocrinol Metab

:

–

Huizenga NA, Koper JW, de Lange P, Pols HA, Stolk RP, Grobbee DE, de Jong FH, Lamberts SW (

b) Inter- person variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feed- back sensitivity of the hypothalamo-pituitary-adrenal axis to a low dose of dexamethasone in elderly individ- uals. J Clin Endocrinol Metab

:

–

Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG (

) Replication validity of genetic association studies. Nat Genet

:

–

Koper JW, Stolk RP, de Lange P, Huizenga NA, Molijn GJ, Pols HA, Grobbee DE, Karl M, de Jong FH, Brinkmann AO, Lamberts SW (

) Lack of association between five polymorphisms in the human glucocorticoid recep- tor gene and glucocorticoid resistance. Hum Genet

:

–

Lin RC, Wang WY, Morris BJ (

) High penetrance, overweight, and glucocorticoid receptor variant: case– control study. BMJ

:

–

Lin RC, Wang XL, Morris BJ (

) Association of coronary artery disease with glucocorticoid receptor N

S variant. Hypertension

:

–

parison based on the Minnesota code. J Electrocardiol

(Suppl):

–

M

wen BS (

) Protective and damaging effects of stress mediators. N Engl J Med

:

–

Munck A, Guyre PM, Holbrook NJ (

) Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr Rev

:

–

Panarelli M, Holloway CD, Fraser R, Connell JM, Ingram MC, Anderson NH, Kenyon CJ (

) Glucocorticoid receptor polymorphism, skin vasoconstriction, and other metabolic intermediate phenotypes in normal human subjects. J Clin Endocrinol Metab

:

–

Rosmond R, Bouchard C, Bjorntorp P (

) Tsp

I poly- morphism in exon

of the glucocorticoid receptor gene in relation to obesity and cortisol secretion: cohort study. BMJ

:

–

Russcher H, van Rossum EF, de Jong FH, Brinkmann AO, Lamberts SW, Koper JW (

) Increased expression of the glucocorticoid receptor-A translational isoform as a result of the ER

/

EK polymorphism. Mol Endocrinol

:

–

van Exel E, Gussekloo J, Houx P, de Craen AJM, Macfarlane PW, Bootsma-van der Wiel A, Blauw GJ, Westendorp RGJ (

) Atherosclerosis and cognitive impairment are linked in the elderly. The Leiden

-plus Study. Athero- sclerosis

:

–

van Rossum EF, Feelders RA, Van Den Beld AW, Uitterlinden AG, Janssen JA, Ester W, Brinkmann AO, Grobbee DE, de Jong FH, Pols HA, Koper JW, Lamberts SW (

a) Association of the ER

/

EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men. Am J Med

:

–

van Rossum EF, Koper JW, Huizenga NA, Uitterlinden AG,