large cohorts of younger to long-term coronary, cardiovascular, and all-cause mortality and to JAMA

,

–

Sun,L., Yang, Z., Jin,F., Zhu, X.Q., Qu, Y.C., Shi, X.H., Wang, L.,

The Gly

Ser especially men. Diabet. Med.

,

–

Tagalakis, A.D., Dickson, J.G., Owen, J.S., Simons, J.P.,

Correction of the neuropathogenic human apolipoprotein E

(APOE

) gene to APOE

in using synthetic RNA/DNA oligonucleotides (chimeraplasts). J. Mol.

,

–

Thompson, A., Di Angelantonio, E., Sarwar, N., Erqou, S., Saleheen, D., Dullaart, Keavney, B., Ye, Z., Danesh, J.,

Association of cholesteryl ester transfer genotypes with CETP mass and activity, lipid levels, and coronary risk. JAMA

–

5. Conclusions

Tothebest of our knowledge,this is thefirststudy to simultaneously investigate thecontributionof CETPand APOE polymorphisms to dyslip- idemia in oldest-old females. Besides the traditional understanding of the association between CETP polymorphism and HDL-c, this study pro- videdevidenceofitseffectonTG,atleastinsub-populations.Theresults provide evidence of strong independent associations between hTG and CETP*Vintheoldest-oldChinesefemalesinthisstudy,andAPOE*4,asan independently non-significant variant, might interact with another var- iant resulting in an increased disease risk. Nevertheless, we fully expect that additional variants, some rare, will be added to the list of polymor- phisms that influence healthy status and life span. It should be noted that this study was conducted based on a limited population because of the rare prevalence of oldest-old in Yongfu (0.0133%). Accordingly, our study is only a first step toward defining a genetic association with hTG in oldest-old Chinese women, and this has to be further repli- cated by long-term prospective studies with larger samples across genders.

Supplementary data to this article can be found online at http://dx. doi.org/10.1016/j.exger.2014.04.003.

Role of the funding source

The State Committee for Scientific Research provided funds for the sample collection and for reagents necessary to perform the experi- ments. It has no role in the study design, in the analysis and interpreta- tion of data, in the writing of the report or in the decision to submit the paper for publication.