) Calorie restriction promotes mito- chondrial biogenesis by inducing the expression of

OS. Science

:

–

Oess S, Icking A, Fulton D, Govers R, Mu¨ller-Esterl W (

) Subcellular targeting and trafficking of nitric oxide syn- thases. Biochem J

:

–

Pacher P, Beckman JS, Liaudet L (

) Nitric oxide and per- oxynitrite in health and disease. Physiol Rev

:

–

Passarino G, Montesanto A, Dato S, Giordano S, Domma F, Mari V, Feraco E, De Benedictis G (

) Sex and age specificity of susceptibility genes modulating survival at old age. Hum Hered

:

–

Paul V, Ekambaram P (

) Involvement of nitric oxide in learning & memory processes. Indian J Med Res

:

–

Reif A, Gru¨nblatt E, Herterich S, Wichart I, Rainer MK, Jung- wirth S, Danielczyk W, Deckert J, Tragl KH, Riederer P,

:

–

Ibarrola-Villava M, Pen˜a-Chilet M, Fernandez LP, Aviles JA, Mayor M, Martin-Gonzalez M, Gomez-Fernandez C, Ca- sado B, Lazaro P, Lluch A, Benitez J, Lozoya R, Boldo E, Pizarro A, Martinez-Cadenas C, Ribas G (

) Genetic polymorphisms in DNA repair and oxidative stress path- ways associated with malignant melanoma susceptibility. Eur J Cancer

:

–

Jung J, Na C, Huh Y (

) Alterations in nitric oxide synthase in the aged CNS. Oxid Med Cell Longev

:

Kader KN, Akella R, Ziats NP, Lakey LA, Harasaki H, Ranieri JP, Bellamkonda RV (

)

OS-overexpressing endo- thelial cells inhibit platelet aggregation and smooth muscle cell proliferation in vitro. Tissue Eng

:

–

Kanski J, Hong SJ, Scho¨neich C (

) Proteomic analysis of protein nitration in aging skeletal muscle and identification of nitrotyrosine-containing sequences in vivo by nano- electrospray ionization tandem mass spectrometry. J Biol Chem

:

–

Katz S, Downs TD, Cash HR, Grotz RC (

) Progress in development of the index of ADL. Gerontologist

:

–

Kawamoto EM, Vasconcelos AR, Degaspari S, Bo¨hmer AE, Scavone C et al (

) Age-related changes in nitric oxide activity, cyclic GMP, and TBARS levels in platelets and erythrocytes reflect the oxidative status in central nervous system. Age (Dordr)

(

):

–

Kim CH, Zou Y, Kim DH, Kim ND, Yu BP, Chung HY (

) Proteomic analysis of nitrated and

-hydroxy-

- nonenal- modified serum proteins during aging. J Gerontol A

:

–

Kirchner L, Weitzdoerfer R, Hoeger H, Url A, Schmidt P, Engelmann M, Villar SR, Fountoulakis M, Lubec G, Lubec B (

) Impaired cognitive performance in neuronal nitric oxide synthase knockout mice is associated with hippocampal protein derangements. Nitric Oxide

:

–

Law A, O’Donnell J, Gauthier S, Quirion R (

) Neuronal and

Fischer P (

a) Association of a functional NOS

pro- moter repeat with Alzheimer’s disease in the VITA cohort. J Alzheimers Dis

:

–

Reif A, Schecklmann M, Eirich E, Jacob CP, Jarczok TA, Kittel- Schneider S, Lesch KP, Fallgatter AJ, Ehlis AC (

b) A functional promoter polymorphism of neuronal nitric oxide synthase moderates prefrontal functioning in schizophre- nia. J Neuropsychopharmacol

:

–

Sheikh JI, Yesavage JA (

) Geriatric Depression Scale (GDS): recent evidence and development of a shorter version. Clinical gerontology: a guide to assessment and intervention. Haworth, New York, pp

–

So HC, Sham PC (

) Robust association tests under different genetic models, allowing for binary or quantitative traits and covariates. Behav Genet

:

–

Strosznajder JB, Jes´ko H, Zambrzycka A, Eckert A, Chal- imoniuk M (

) Age-related alteration of activity and gene expression of endothelial nitric oxide synthase in different parts of the brain in rats. Neurosci Lett

:

–

Taddei S, Virdis A, Ghiadoni L (

) Age-related reduction of NO availability and oxidative stress in humans. Hyper- tension

:

–

Toprakci M, Ozmen D, Mutaf I, Turgan N, Parildar Z, Habif S, Guner I, Bayindir O (

) Age-associated changes in nitric oxide metabolites nitrite and nitrate. Int J Clin Lab Res

:

–

Torregrossa AC, Aranke M, Bryan NS (

) Nitric oxide and geriatrics: implications in diagnostics and treatment of the elderly. J Geriatr Cardiol

:

–

Tsutsui M, Shimokawa H, Otsuji Y, Ueta Y, Sasaguri Y, Yan- agihara N (

) Nitric oxide synthases and cardiovascular diseases: insights from genetically modified mice. Circ J

:

–

van der Loo B, Labugger R, Skepper JN, Bachschmid M, Kilo J, Powell JM, Palacios-Callender M, Erusalimsky JD,

Quaschning T, Malinski T, Gygi D, Ullrich V, Lu¨scher TF (

) Enhanced peroxynitrite formation is associated with vascular aging. JExp Med

:

–

Villanueva C, Giulivi C (

) Subcellular and cellular loca- tions of nitric oxide synthase isoforms as determinants of health and disease. Free Radic Biol Med

:

–

Weitzdoerfer R, Hoeger H, Engidawork E, Engelmann M, Singewald N, Lubec G, Lubec B (

) Neuronal nitric oxide synthase knock-out mice show impaired cognitive performance. Nitric Oxide

:

–

Wigginton JE, Cutler DJ, Abecasis GR (

) A note on exact tests of Hardy–Weinberg equilibrium. Am J Hum Genet

:

–

Wink DA, Hines HB, Cheng RY, Switzer CH, Flores-Santana W, Vitek MP, Ridnour LA, Colton CA (

) Nitric oxide and redox mechanisms in the immune response. J Leukoc Biol

:

–

Yang B, Larson DF, Watson RR (

) Modulation of

OS activity in age-related cardiac dysfunction. Life Sci

:

–

Yoon HJ, Cho SW, Ahn BW, Yang SY (

) Alterations in the activity and expression of endothelial NO synthase in aged human endothelial cells. Mech Ageing Dev

:

–

Zhou QG, Hu Y, Hua Y, Hu M, Luo CX, Han X, Zhu XJ, Wang B, Xu JS, Zhu DY (

) Neuronal nitric oxide synthase contributes to chronic stress-induced depression by sup- pressing hippocampal neurogenesis. J Neurochem

:

–

Zoubovsky SP, Pogorelov VM, Taniguchi Y, Kim SH, Yoon P, Nwulia E, Sawa A, Pletnikov MV, Kamiya A (

) Working memory deficits in neuronal nitric oxide synthase knockout mice: potential impairments in prefrontal cortex mediated cognitive function. Biochem Biophys Res Commun

:

–