We thank all probands for their participation. We are grateful to I. Urbach, T. Henke, B. Petersen, and T. Wesse for technical assistance; R. Vogler for database management; and J. Heinze for help with recruit- ment. This study was funded by the Federal Ministry of Science and Education through an Explorative Project of the National Genome Research Network (NGFN-2). We acknowledge the support of our collaborators in the Genetics of Healthy Aging Consortium (GEHA), 6th Framework Program of the European Commission.

More work will be required to discern which of the above explanations for the lack of replication of an original association

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