Acknowledgements: The Gruppo di Studio sull'Immunosenescenza coordinated by Professor C Caruso is funded by grants from the Italian Ministry of Education, University and Research (MIUR) (ex40%, to CC and DL; ex60% to CC, DL, GC, and GCR) and from the Italian Ministry of Health Projects Immunological Parameters Age-Related and Pharmacogenomics of Alzheimer's Disease. The collaboration between this group and the Istituto Nazionale di Riposo e Cura per Anziani was enhanced by a cooperation contract (Longevity and Elderly Disability Biological Markers) and by the EU thematic network program ImAginE characterizing the distal flanking region of the human interleukin-gene.

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