Locus SNPs 90110 8089 1079 (n =113) (n =75) (n =125) 
74 W T  	95.58  	88.00  	90.40   
M G  	4.42  	12.00  	9.60   
80 W C  	98.23  	81.33  	88.00   
M1 G  	1.77  	8.00  	4.84   
M2 T  	0.00  	10.67  	7.16   
94 W G  	93.81  	90.67  	94.40   
M A 	6.19 	9.33 	5.60 
103 W G 98.23 98.67 98.40 
M1 A 0.00 1.33 1.60 
M2 Del 1.77 0.00 0.00 
131 W T 98.23 98.67 98.40 
M C 1.77 1.33 1.60 
146 W T 69.03 84.00 85.60 
M1 C 29.20 13.33 12.00 
M2 A 1.77 2.67 2.40 
150 W C 73.45 70.67 80.80 
M T 26.55 29.33 19.20 
151 W C 92 .92  	94 .67  	93 .60   
M T  	7 .08   	5 .33   	6 .40    
152 W T  	76 .11   	81 .33   	81 .60    
M1 C   	8 .85   	16 .00   	15 .20    
M2 A   	15 .04   	2 .67   	3 .20    
185 W G  	90 .27   	88 .00   	88 .80    
M1 A   	4 .42   	5 .33   	4 .80    
M2 C   	5 .31   	6 .67   	6 .40    
189 W A  	95 .58   	97 .33   	98 .40    
M G  	4 .42   	2 .67   	1 .60    
195 W T  	93 .81   	97 .33   	92 .80    
M C  	6 .19   	2 .67   	7 .20    
199 W T  	79 .65   	73 .33   	82 .40    
M C  	20 .35   	26 .67   	17 .60    
204 W T  	92 .04   	89 .33   	92.80   
M C  	7.96   10.67 7.20 
207 W G 89.38 80.00 88.00 
M A 10.62 20.00 12.00 
210 W A 94.69 92.00 93.60 
M G 5.31 8.00Four human populations, including Irish, Finnish, Japanese, and Italian [8, 23, 35], have been studied for the mt150T genotype. This genotype may prolong longevity by conferring a replication advantage to mtDNA, leading to homoplasmic or nearly homoplasmic levels mainly found in cells from centenarians. Additionally, the mt150T polymorphism may provide resistance to oxidative stress and apoptosis [35]. The mt146 is located in the D-loop region and near mt150 of the mtDNA control region. Therefore, it is logical to speculate that mt146C has a similar function to that of mt150T and contributes to prolonged lifespan in Guangxi Bama. Although mt5178A has been shown to be associated with longevity in Japanese and European populations [36], our results show that mt5178A is not significantly associated with Bama longevity. The reason for this discrepancy is unclear. Nevertheless, we found that the mt5178C/A polymorphisms are strongly associated with nationality in the Guangxi Bama population. The Yao have a much higher rate of mt5178A and a much lower rate of mt5178C than the Han and Zhuang nationalities. Aging and longevity are affected by complex factors beyond just mtDNA; the nucleus is also involved in ways critical to human mitochondrial control sites for replication [1-4]. 

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