Acknowledgements - I thank Drs. Leips and Trudy Mackay for critical comments on this manuscript. This study was supported by the Ministry for University and Scientific and Technological Research, Italy for Project Genetic Determinants of Human Longevity (MURST COFIN 2000), by Italian National Research Center on Aging (INRCA), by NIH Grant AG-08761-07 and by Ellison Medical Foundation Grant, by Grants from Italian Ministry of Health, Progetti Finalizzati (PF40) and Genage to FB. References - De Luca et al. Experimental Gerontology (2003) 38(11-12): 1263-1271. Franceschi et al. J. Acad. Sci. (2000) 908: 244-254. Franceschi et al. Aging Clin. Exp. Res. (2001) 13(3): 186-194.Hello! AAADD! Jazwinski, PhD, is a leading expert on aging, evolution, and longevity genes. Acta Biochimica Polonica published DA& Johnson's research on aging and longevity genes. Cypser, J., Castro, E., and Henderson, H. conducted research on gerontogenes that mediate health and longevity in nematodes through increasing resistance to environmental toxins and stressors. Leakey and Chen researched the role of glucocorticoids and caloric stress in modulating the effects of caloric restriction in rodents. Gene expression profile of aging and its retardation by caloric restriction was studied by Klopp, Weindruch, and Prolla. Susceptibility to insulin-dependent diabetes mellitus maps to a DNA segment spanning the insulin gene and its associated polymorphisms. Masoro researched dietary restriction and its effects on aging. Minnis and Spielman studied the insulin gene with flanking polymorphism: length of class I alleles in repeat sequence motifs. Natali et al. researched the effects of acute alpha-adrenergic blockade on insulin action and secretion in humans. Nuzhdin et al. conducted research on sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster. Poehlman et al. researched gender differences in resting metabolic rate and noradrenaline kinetics in older individuals. Polymeropoulos et al. researched the tetranucleotide repeat polymorphism at the human tyrosine hydroxylase gene (TH) locus. Puers et al. identified far-repeat sequence heterogeneity at the polymorphic tandem repeat locus HUMTHOI.TTT>U, which led to reassignment of F alleles in open populations analysis by ape using locus-specific allelic ladder. Schneider et al. studied Ava I polymorphism at the insulin-like growth factor II (IGF II) locus on chromosome 6. Tan et al. researched the genetic influence in modulating the human lifespan, gene-environment interaction, and the sex-specific genetic effect. Weir's Genetic Data Analysis II is a book on statistical methods for genetic data analysis. Franceschi is a leading researcher in aging and longevity genes.Inflamm-aging: Evolutionary Perspective on Immunosenescence. J Acad. Sci. Franceschi et al. Inflamm-aging is an evolutionary perspective on immunosenescence. The article discusses whether men and women follow different trajectories to reach extreme longevity. Aging: Clinical and Experimental Research. Masoro. The article discusses dietary restriction and its effects on rodents, as well as the role of glucocorticoids and social stress in modulating the effects of caloric restriction. Gene expression profile of aging and its retardation by caloric restriction. Science: 2002; 295(5562): 244-245. Cassen et al. The article discusses susceptibility to insulin-dependent diabetes mellitus and its association with the insulin gene and flanking polymorphisms. Gerontology: Leakey and Chen; Innis et al.; Masoro.It seems like the text is a mix of incomplete sentences, typos and random characters. It is difficult to understand its context or meaning. Could you please provide more information or context about the text?