Acknowledgements:
Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, UK; Simon Mead, MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; Nick Fox and Martin Rossor, Dementia Research Centre, Department of Neurodegenerative Diseases, University College London, Institute of Neurology, London, UK; John Collinge, MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; Wolfgang Maier, Frank Jessen, Reiner Heun and Heike Klsch from the Department of Psychiatry at the University of Bonn in Bonn Germany; Britta Schrmann from the Department of Psychiatry and Institute for Molecular Psychiatry at the University of Bonn in Bonn Germany; Hendrik van den Bussche from the Institute of Primary Medical Care at the University Medical Center Hamburg-Eppendorf in Germany; Isabella Heuser from the Department of Psychiatry at Charit in Berlin Germany; Johannes Kornhuber from the Department of Psychiatry at the University of Erlangen in Nrnberg Germany; Jens Wiltfang from LVR-Hospital Essen from the Department of Psychiatry and Psychotherapy at the University Duisburg-Essen in Germany; Martin Dichgans from the Institute for Stroke and Dementia Research and Department of Neurology at Klinikum der Universitt Mnchen in Munich Germany; Lutz Frlich from Central Institute of Mental Health Medical Faculty Mannheim at the University of Heidelberg in Germany; Harald Hampel from the Department of Psychiatry Psychosomatic Medicine and Psychotherapy at Goethe University in Frankfurt Germany; Michael Hll from the Centre for Geriatric Medicine and Section of Gerontopsychiatry and Neuropsychology at the Medical School, University of Freiburg in Germany; Dan Rujescu from Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig-Maximilian University, Munich, Germany; Alison Goate from the Departments of Psychiatry, Neurology and Genetics at Washington University School of Medicine in St. Louis, MO, USA; John S.K. Kauwe from the Department of Biology at Brigham Young University in Provo, UT, USA; Carlos Cruchaga, Petra Nowotny, John C. Morris and Kevin Mayo from the Departments of Psychiatry, Neurology and Genetics at Washington University School of Medicine in St. Louis, MO, USA; Gill Livingston, Nicholas J. Bass, Hugh Gurling and Andrew McQuillin from the Department of Mental Health Sciences at University College London in London UK; Rhian Gwilliam and Panagiotis Deloukas from The Wellcome Trust Sanger Institute Wellcome Trust Genome Campus in Hinxton Cambridge UK; Markus M. Nthen from the Department of Genomics at Life and Brain Center at the University of Bonn in Bonn Germany; Peter Trust from Medical Research Council (MRC), Alzheimers Research Trust (ART) and the Welsh Assembly Government. ART supported sample collections at Kings College London, the South West Dementia Bank, Universities of Cambridge, Nottingham, Manchester and Belfast. The Belfast group acknowledges support from the Alzheimers Society Ulster Garden Villages N. Ireland R&D Office and the Royal College of Physicians/Dunhill Medical Trust. The MRC and Mercers Institute for Research on Ageing supported the Trinity College group. The South West Dementia Brain Bank acknowledges support from Bristol Research into Alzheimers and Care of the Elderly. The Charles Wolfson Charitable Trust supported the OPTIMA group. Washington University was funded by NIH grants, Barnes Jewish Foundation and the Charles and Joanne Knight Alzheimers Research Initiative. Patient recruitment for the MRC Prion Unit/UCL Department of Neurodegenerative Disease collection was supported by the UCLH/UCL Biomedical Centre. LASER-AD was funded by Lundbeck SA. The Bonn group was supported by the German Federal Ministry of Education and Research (BMBF), Competence Network Dementia and Competence Network Degenerative Dementia, and by the Alfried Krupp von Bohlen und Halbach-Stiftung. The GERAD1 Consortium also used samples ascertained by the NIMH AD Genetics Initiative.

Disclosure statement:
The authors declare that there are no conflicts of interest. Approval was obtained from the ethics committee or institutional review board of each institution responsible for the ascertainment and collection of samples. Written informed consent was obtained for all individuals who participated in this study.

Acknowledgements:
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