b) Cytokine gene poly- morphisms and atherosclerosis. In: Vandenbroeck K (ed) Cytokine gene polymorphisms in multifactorial conditions. ISBN:

Florida, CRC press Caruso C, Candore G, Cavallone L, Colonna-Romano G, Scola L, Hoffman E, Caruso M, Franceschi C, Lio D (

) Genetic background of centenarians may be protective against cardiovascular diseases. Interna- tional Congress of Immunology

–

ISBN/ISSN:

-

-

-

Caruso C, Candore G, Colonna-Romano G, Lio D, Franceschi C (

) Inflammation and life-span. Sci- ence

:

–

Cox DW (

) Alpha-

antitrypsin deficiency. In: Scriver C, Beaudet A, Sly W, Valle D (eds) The metabolic and molecular bases of inherited disease,

th edn. M

raw-Hill, New York, p

Dahl M, Tybjaerg-Hansen A, Sillesen H, Jensen G, Steffensen R, Nordestgaard BG (

) Blood Pressure, risk of ischemic cerebrovascular and ische- mic heart disease, and longevity in a -antitrypsin

deficiency. Circulation

:

–

SA, Dykes DD, Polesky HF (1998) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acid Res 16:1215

Nieminen MS, Kesaniemi YA, Pasternack A, Humphries SE, Syvanne M (

) Progression of atherosclerosis is associated with variation in the a -antitrypsin gene. Arterioscler Thromb Vasc Biol

:

–

Tazelaar JP, Friedman KJ, Kline RS, Guthrie ML, Farber RA (

). Detection of a -antitrypsin Z

and S mutations by polymerase chain reaction- mediated site-directed mutagenesis. Clin Chem

:

–

Terry DF, Wilcox M, M

ormick MA, Lawler E, Perls TT (

) Cardiovascular advantages among the offspring of centenarians. J Gerontol A Biol Sci Med Sci

:

–

Zureik M, Robert L, Courbon D (

) Serum elastase activity, serum elastase inhibitors, and occurrence of carotid atherosclerotic plaques: the etude sur le vieillissement arteriel (EVA) study. Circulation

:

–

Needham M, Stockley RA (

) a -antitrypsin

: Clinical manifestations and natural history.

:

–

Ooyama T, Sakamato H (

) Elastase in the of arterial ageing and the treatment of In: The molecular biology and patology of tissues. Ciba Found Symp

:

–

Robert L, Robert AM, Jacotot B (

) atherosclerosis revisited. Atherosclerosis Seersholm N (

) P

Z and COPD: will we ever Thorax

:

–

Risk of hospital admission for obstructive disease in a -antitrypsin heterozygotes of

P

Z. Am J Respir Crit Care Med

:

–

St Jean P, Hart B, Webster M, Steed D, Adamson Powell J, Ferrell R (

) Alpha-

-antitrypsin ciency in aneurysmal disease. Hum Hered

:

–

Talmud PJ, Martin S, Steiner G, Flavell DM, DB, Nagl S, Jackson R, Taskinen MR, Frick