Acknowledgments:

D.E.A. is supported by National Institute of Mental Health grant MH070172 and by the Donald W. Reynolds Foundation Clinical Cardiovascular Research Center grant to Johns Hopkins University. G.A. and N.B. are supported by grants from the Paul Beeson physician faculty scholar in aging award, the Ellison Medical Foundation senior scholar award, RO1 (AG-18728-01A1), Aging Einstein Study (P01 AG-03949-01A1), the General Clinical Research Center (MO1-RR12248) and Diabetes Research and Training Center (DK 20541) at the Albert Einstein College of Medicine, and the Baltimore VA Geriatric Research and Education Clinical Center. H.C.D. is supported by the Howard Hughes Medical Institute.

Allele on longevity has been limited to cross-sectional data; the current study incorporates prospective mortality data generated in individuals 95 years of age. As observed in the cross-sectional analyses of CVD risk factors and events, heterozygous individuals had a marked advantage. Wild-type individuals have an increased RR of 2.15 (95% CI, 1.18 to 3.91), and homozygous KL-VS individuals have a 4.49-fold increased RR (95% CI, 1.35 to 14.97) for mortality relative to heterozygous individuals, after adjusting for potential confounders. These data strongly support a role for the KL-VS allele in longevity.

References:

Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI. Mutation of the mouse klotho gene leads to a syndrome resembling aging. Nature.; : 

Saito Y, Yamagishi T, Nakamura T, Ohyama Y, Aizawa H, Suga T, Matsumura Y, Masuda H, Kurabayashi M, Kuro-o M, Nabeshima Y, Nagai R. Klotho protein protects against endothelial dysfunction. Biochem Biophys Res Commun.; : 

Fukino K, Suzuki T, Saito Y, Shindo T, Amaki T, Kurabayashi M, Nagai R. Regulation of angiogenesis by the aging suppressor gene klotho. Biochem Biophys Res Commun.; : 

Arking DE, Krebsova A, Macek M Sr., Macek M Jr., Arking A, Mian IS, Fried L, Hamosh A, Dey S,
McIntosh I, Dietz HC. Association of human aging with a functional variant of klotho. Proc Natl Acad Sci U S A.; : 

Arking DE, Becker DM,
Yanek LR,
Fallin D,
Judge DP,
Moy TF,
Becker LC,
Dietz HC. KLOTHO allele status and the risk of early-onset occult coronary artery disease. Am J Hum Genet.; : 

Tohyama O, Imura A, Iwano A, Freund JN, Henrissat B, Fujimori T, Nabeshima Y. Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides. J Biol Chem.; : 

Xiao NM, Zhang YM, Zheng Q, Gu J. Klotho is a serum factor related to human aging. Chin Med J (Engl).; : 

Takeshita K, Fujimori T, Kurotaki Y, Honjo H, Tsujikawa H, Yasui K, Lee JK, Kamiya K, Kitaichi K, Yamamoto K, Ito M, Kondo T, Iino S, Inden Y,
Hirai M,
Murohara T,
Kodama I,
Nabeshima Y. Sinoatrial node dysfunction and early unexpected death of mice with a defectI'm sorry, but there is no context or sentence for me to correct or improve. Could you please provide me with more information or the full text that needs to be processed?