receptor correlates with male longevity in the Italian lation: a genetic study and evaluation of circulating from the "Treviso Longeva (TRELONG)" study. BMC iatr

;

;

:

De Benedictis G, Rose G, Carrieri G, De Luca M, Falcone Passarino G, Bonafe M, Monti D, Baggio G, Bertolini S, D, Mattace R, Franceschi C. Mitochondrial DNA variants are associated with successful aging and in humans. FASEB J

;

:

–

Laplana M, Fibla J. Distribution of functional variants of inflammation-related genes RANTES and in long-lived individuals. Cytokine.

;

:

–

Bellizzi D, Rose G, Cavalcante P, Covello G, Dato S, Rango F, Greco V, Maggiolini M, Feraco E, Mari V, ceschi C, Passarino G, De Benedictis G. A novel VNTR hancer within the SIRT

gene, a human homologue of is associated with survival at oldest ages.

;

:

–

De Benedictis G, Carotenuto L, Carrieri G De Luca M, cone E, Rose G, Cavalcanti S, Corsonello F, Feraco E, G, Bertolini S, Mari D, Mattace R, Yashin AI, Bonafe` Franceschi C. Gene/longevity association studies at autosomal loci (REN, THO, PARP, SOD

). Eur J Hum

;

:

–

Cardelli M, Cavallone L, Marchegiani F, Oliveri F, Dato Montesanto A, Lescai F, Lisa R, De Benedictis G, C. A genetic-demographic approach reveals association between survival and tumor necrosis (A/G)-

polymorphism. J. Gerontol. A Biol Sci Med

;

:

–

Di Bona D, Vasto S, Capurso C, Christiansen L, Deiana L, Franceschi C, Hurme M, Mocchegiani E, Rea M, Lio D, Candore G, Caruso C. Effect of interleukin-

polymorphisms on human longevity: A systematic review and meta- analysis. Ageing Res Rev

;

:

–

Lio D, Scola L, Crivello A, Colonna-Romano G, Candore G, Bonafe` M, Cavallone L, Franceschi C, Caruso C. Gender- specific association between -

IL-

promoter poly- morphism and longevity. Genes Immun

;

:

–

Khabour OF, Barnawi JM. Association of longevity with IL-

-

G/A and TNF-alpha -

G/A polymorphisms. Int J Immunogenet.

;

:

–

Bordone L, Guarente L. Calorie restriction, SIRT

and me- tabolism: Understanding longevity. Nat Rev Mol Cell Biol

;

:

–

Abete I, Navas-Carretero S, Marti A, Martinez JA. Nutrigenetics and nutrigenomics of caloric restriction. Prog Mol Biol Transl Sci.

;

:

–

Kinsella KG. Future longevity-demographic concerns and consequences. J Am Geriatr Soc.

;

(

Suppl):S

–S

Napolioni V, Lucarini N. Gender-specific association of ADA genetic polymorphism with human longevity. Biogerontol- ogy

;

:

–

Napolioni V, Carpi FM, Giann`ı P, Sacco R, Di Blasio L, Mignini F, Lucarini N, Persico AM. Age- and gender-specific epistasis between ADA and TNF-a influences human life- expectancy. Cytokine

;

:

–

Khabour OF, Mesmar FS, Alatoum MA, Gharaibeh MY, Alzoubi KH. Associations of polymorphisms in adiponectin and leptin genes with men’s longevity. Aging Male

;

:

–

Nebel A, Flachsbart F, Till A, Caliebe A, Blanche´ H, Arlt A, Ha¨sler R, Jacobs G, Kleindorp R, Franke A, Shen B, Nikolaus S, Krawczak M, Rosenstiel P, Schreiber S. A functional EXO

promoter variant is associated with prolonged life expec- tancy in centenarians. Mech Ageing Dev

;

:

–

Li Y, Wang WJ, Cao H, Lu J, Wu C, Hu FY, Guo J, Zhao L, Yang F, Zhang YX, Li W, Zheng GY, Cui H, Chen X, Zhu Z, He H, Dong B, Mo X, Zeng Y, Tian XL. Genetic association of FOXO

A and FOXO

A with longevity trait in Han Chi- nese populations.Hum Mol Genet

;

:

–

van Heemst D, Beekman M, Mooijaart SP, Heijmans BT, Brandt BW, Zwaan BJ, Slagboom PE, Westendorp RG. Re- duced insulin/IGF-

signalling and human longevity. Aging Cell

;

:

–

Lio D, Scola L, Crivello A, Bonafe` M, Franceschi C, Olivieri F, Colonna-Romano G, Candore G, Caruso C. Allele fre- quencies of +

T/A single nucleotide polymorphism at

Rosa Maria Corbo La Sapienza University Department of Biology and Biotechnology Piazzale A. Moro

Rome

E-mail: rosamaria.corbo@uniroma1.it