Replication Samples

Whitehall II: Whitehall II has been supported by grants from the Medical Research Council; Economic and Social Research Council; British Heart Foundation; Health and Safety Executive; Department of Health; National Heart Lung and Blood Institute (HL36310), US NIH National Institute on Aging (AG13196), US NIH Agency for Health Care Policy Research (HS06516); and the John D. and Catherine T. MacArthur Foundation Research Networks on Successful Midlife Development and Socio-economic Sta- tus and Health.

ses were supported by the National Institute of Aging grant number R01AG029451 (PI: JMM). The Framing- ham Heart Study of the National Heart Lung and Blood Institute of the National Institutes of Health and Boston University School of Medicine were supported by the National Heart, Lung and Blood Institute’s Framingham Heart Study Contract No. N01-HC-25195 and its contract with Affymetrix, Inc., for genotyping services (Contract No. N02-HL-6-4278). Analyses reflect intellectual input and resource development from the Framingham Heart Study investigators participating in the SNP Health As- sociation Resource (SHARe) project. A portion of this research was conducted using the Linux Cluster for Ge- netic Analysis (LinGA-II) funded by the Robert Dawson Evans Endowment of the Department of Medicine at Boston University School of Medicine and Boston Med- ical Center. Dr. Kiel’s effort as well as all hip fracture data from the Framingham Osteoporosis Study was sup- ported by a grant from the National Institute of Arthritis, Musculoskeletal and Skin Diseases and the National In- stitute on Aging; R01 AR/AG 41398. This research was additionally supported by the following grants: AG033193, AG081220, NS17950, P30AG013846, 1R01- AG028321.

English Longitudinal Study of Aging: Samples from the English Longitudinal Study of Ageing (ELSA) DNA Re- pository (EDNAR), received support under a grant (AG1764406S1) awarded by the National Institute on Age- ing (NIA). ELSA was developed by a team of researchers based at the National Centre for Social Research, University College London and the Institute of Fiscal Studies. The data were collected by the National Centre for Social Research. Religious Order Study: Grants P30AG10161,

Religious Order Study: Grants P30AG10161, R01AG15819, and R01AG30146 from the National Insti- tute on Aging, and the Translation Genomics Research Institute.

Memory and Aging Project: Grants R01AG17917 and R01AG15819 from the National Instiute on Aging, and the Translation Genomics Research Institute.

The Longevity Consortium, funded by the National In- stitute of Aging, grant number U19 AG023122, provided administrative resources to CHARGE investigators for this phenotype as well as scientific opportunity funds for de novo genotyping of the 5 selected SNPs in the ELSA and Whitehall II replication studies.

Acknowledgements

Rotterdam Study: The Rotterdam Study is supported by Netherlands Genomics Initiative/Netherlands Consortium for Healthy Aging (050-060-810); Netherlands Organisa- tion for Scientific Research (NWO) (904-61-090, 904-61- 193, 480-04-004, 400-05-717, SPI 56-464-1419, 175.010. 2005.011, 911-03-012 and 017.106.370); Netspar—Living longer for a good health; the Erasmus Medical Center, and Erasmus University in Rotterdam; the Netherlands Organi- zation for Health Research and Development, the Nether- lands Research Institute for Diseases in the Elderly; the Dutch Ministry of Education, Culture and Science, and the Ministry for Health, Welfare and Sports; the European Commission; and the Municipality of Rotterdam, the Neth- erlands.

Atherosclerosis Risk in Communities Study: The Ath- erosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01- HC-55021, and N01-HC-55022. The authors thank the staff and participants of the ARIC study for their important contributions.

Age, Gene/Environment Susceptibility -Reykjavik Study: The Age, Gene/Environment Susceptibility-Reykja- vik Study is funded by NIH contract N01-AG-12100, the NIA Intramural Research Program, Hjartavernd (the Icelan- dic Heart Association), and the Althingi (the Icelandic Par- liament). Genotyping was conducted at the NIA IRP Lab- oratory of Neurogenetics.

Cardiovascular Health Study: The CHS research re- ported in this article was supported by contract numbers N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC-55222, N01-HC-75150, N01-HC- 45133, grant numbers U01 HL080295 and R01 HL087652 from the National Heart, Lung, and Blood Institute, the

Invecchiare nel Chianti: The InCHIANTI study baseline (1998–2000) was supported as a “targeted project” (ICS110.1/RF97.71) by the Italian Ministry of Health and in

part by the U.S. National Institute on Aging (Contracts: 263 MD 9164 and 263 MD 821336).

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