Supplementary material can be found at: http://biomed.gerontologyjournals.

Acknowledgments: We are indebted to the participants and staff in the AGES-Reykjavik, the CHS, the FHS, and the RS for their important contributions. We acknowledge the NHLBI, which has made the Framingham SNP Health Association Resource project possible. Numbers N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01-HC-15103, N01-HC-55222, N01-HC-75150, and N01-HC-45133 and grant numbers U01 HL080295 and R01 HL087652 from the NHLBI and R01 AG023629 from the NIA, with additional contribution from the National Institute of Neurological Disorders and Stroke. A full list of principal CHS investigators and institutions can be found at http://www.chs-nhlbi.org/pi.htm. DNA handling and genotyping were supported in part by National Center for Research Resources grant M01-RR00425 to the Cedars-Sinai General Clinical Research Center Genotyping core and National Institute of Diabetes and Digestive and Kidney Diseases grant DK063491 to the Southern California Diabetes Endocrinology Research Center. The FHS phenotype-genotype analyses were supported by the NIA grant numbers R01AG029451, R01AG028321, R01AG033193, and R01 AG031287. The FHS of the NHLBI of the National Institutes of Health (NIH) and Boston University School of Medicine were supported by the NHLBI's FHS contract number N01-HC-25195 and its contract with Affymetrix, Inc. for genotyping services (contract number N02-HL-6-4278). Analyses reflect intellectual input and resource development from the FHS investigators participating in the SNP Health Association Resource project. A portion of this research was conducted using the Linux Cluster for Genetic Analysis (LinGA-II) funded by the Robert Dawson Evans Endowment of the Department of Medicine at Boston University School of Medicine and Boston Medical Center. D.P.K.'s effort was supported by a grant from the National Institute of Arthritis, Musculoskeletal and Skin Diseases and the NIA (R01 AR/AG 41398). The RS is supported by the Erasmus Medical Center and Erasmus University Rotterdam; the Netherlands Organisation for Scientific Research (NWO); the Netherlands Organisation for Health Research and Development (ZonMw); the Research Institute for Diseases in the Elderly; the Ministry of Education, Culture and Science; the Ministry of Health, Welfare and Sports; and the European Commission (DG XII). The genetic analyses were supported by the Netherlands Organization for Scientific Research grant number 175.01.2005.011. This study was supported by the Netherlands GenSorry, but the text enclosed in ``` ``` was just a list of references, and it did not need any proofreading or editing. Is there anything else I can help you with?Study. Exp Gerontol. ; (): Saugstad JA, Roberts JA, Dong J, Zeitouni S, Evans RJ. Analysis of the membrane topology of the acid-sensing ion channel a. J Biol Chem. ; (): Waldmann R, Champigny G, Voilley N, Lauritzen I, Lazdunski M. The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans. J Biol Chem. ; (): Bernardinelli L, Murgia SB, Bitti PP, et al. Association between the ACCN gene and multiple sclerosis in Central East Sardinia. PLoS One. ; ():e Page NM, Butlin DJ, Lomthaisong K, Lowry PJ. The characterization of pregnancy-associated plasma protein-E and the identification of an alternative splice variant. Placenta. ; (): Conover CA, Bale LK. Loss of pregnancy-associated plasma protein A extends lifespan in mice. Aging Cell. ; (): Vallejo AN, Michel JJ, Bale LK, Lemster BH, Borghesi L, Conover CA. Resistance to age-dependent thymic atrophy in long-lived mice that are deficient in pregnancy-associated plasma protein A. Proc Natl Acad Sci. ; () from http://biomedgerontology.oxfordjournals.org/ at National Sun Yat-sen University on August 22, 2014