,

–

Manolio TA, Brooks LD, Collins FS (

) A Ha

ap harvest of insights into the genetics of common disease. J. Clin. Invest.

,

–

M

arthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, Ioannidis JP, Hir- schhorn JN (

) Genome-wide association studies for complex traits: con- sensus, uncertainty and challenges. Nat. Rev. Genet.

,

–

M

lintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS, Dja- bali K (

) The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin. PL

One

, e

Merideth MA, Gordon LB, Clauss S, Sachdev V, Smith AC, Perry MB, Brewer CC, Zalewski C, Kim HJ, Solomon B, Brooks BP, Gerber LH, Turner ML, Domingo DL, Hart TC, Graf J, Reynolds JC, Gropman A, Yanovski JA, Gerhard-Herman M, Collins FS, Nabel EG, Cannon RO III, Gahl WA, Introne WJ (

) Pheno- type and course of Hutchinson-Gilford progeria syndrome. N. Engl. J. Med.

,

–

Nebel A, Kleindorp R, Caliebe A, Nothnagel M, Blanche H, Junge O, Wittig M, Ellinghaus D, Flachsbart F, Wichmann HE, Meitinger T, Nikolaus S, Franke A, Krawczak M, Lathrop M, Schreiber S (

) A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals. Mech. Ageing Dev.

,

–

Novelli V, Viviani Anselmi C, Roncarati R, Guffanti G, Malovini A, Piluso G, Puca AA (

) Lack of replication of genetic associations with human longevity. Biogerontology

,

–

Park SK, Kim K, Page GP, Allison DB, Weindruch R, Prolla TA (

) Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants. Aging Cell

,

–

Patterson N, Price AL, Reich D (

) Population structure and eigenanalysis. PL

Genet.

, e

Pawlikowska L, Hu D, Huntsman S, Sung A, Chu C, Chen J, Joyner AH, Schork NJ, Hsueh WC, Reiner AP, Psaty BM, Atzmon G, Barzilai N, Cummings SR, Browner WS, Kwok PY, Ziv E (

) Association of common genetic variation in the insulin⁄IGF

signaling pathway with human longevity. Aging Cell

,

–

Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D (

) Principal components analysis corrects for stratification in genome-wide associ- ation studies. Nat. Genet.

,

–

R Development Core Team (

) R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing. Renaud S, de Lorgeril M (

) Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet

,

–

Rodriguez S, Eriksson M (

) Low and high expressing alleles of the LMNA gene: implications for laminopathy disease development. PL

One

, e

Rodriguez S, Coppede F, Sagelius H, Eriksson M (

) Increased expression of the Hutchinson-Gilford progeria syndrome truncated lamin A transcript during cell aging. Eur. J. Hum. Genet.

,

–

Scaffidi P, Misteli T (

) Lamin A-dependent nuclear defects in human aging. Science

,

–

Sebastiani P, Solovieff N, D

an A, Walsh K, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Bald- win CT, Hoh J, Perls TT (

). Genetic signatures of exceptional longevity in humans. PL

One

, e

Skytthe A, Pedersen NL, Kaprio J, Stazi MA, Hjelmborg JV, Iachine I, Vaupel JW, Christensen K (

) Longevity studies in Geno

Utwin. Twin Res.

,

–

Soerensen M, Dato S, Christensen K, M

ue M, Stevnsner T, Bohr VA, Christian- sen L (

) Replication of an association of variation in the FOXO

A gene with human longevity using both case-control and longitudinal data. Aging Cell

,

–

Tan Q, Zhao JH, Zhang D, Kruse TA, Christensen K (

) Power for genetic association study of human longevity using the case-control design. Am. J. Epidemiol.

,

–

Tian C, Plenge RM, Ransom M, Lee A, Villoslada P, Selmi C, Klareskog L, Pulver AE, Qi L, Gregersen PK, Seldin MF (

) Analysis and application of European genetic substructure using

K SNP information. PL

Genet.

, e

Willcox BJ, Donlon TA, He Q, Chen R, Grove JS, Yano K, Masaki KH, Willcox DC, Rodriguez B, Curb JD (

) FOXO

A genotype is strongly associated with

References

Anselmi CV, Malovini A, Roncarati R, Novelli V, Villa F, Condorelli G, Bellazzi R, Puca AA (

) Association of the FOXO

A locus with extreme longevity in a southern Italian centenarian study. Rejuvenation Res.

,

–

Armitage P (

) Tests for linear trends in proportions and frequencies. Biomet- rics

,

–

Cao K, Capell BC, Erdos MR, Djabali K, Collins FS (

) A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells. Proc. Natl Acad. Sci. USA

,

–

Cao K, Blair CD, Faddah DA, Kieckhaefer JE, Olive M, Erdos MR, Nabel EG, Col- lins FS (

) Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts. J. Clin. Invest.

,

–

Capell BC, Collins FS (

) Human laminopathies: nuclei gone genetically awry. Nat. Rev. Genet.

,

–

Capell BC, Collins FS, Nabel EG (

) Mechanisms of cardiovascular disease in accelerated aging syndromes. Circ. Res.

,

–

Castro E, Edland SD, Lee L, Ogburn CE, Deeb SS, Brown G, Panduro A, Riestra R, Tilvis R, Louhija J, Penttinen R, Erkkola R, Wang L, Martin GM, Oshima J (

) Polymorphisms at the Werner locus: II.

Leu⁄Phe,

Cys⁄Arg, longevity, and atherosclerosis. Am. J. Med. Genet.

,

–

Christensen K, Johnson TE, Vaupel JW (

) The quest for genetic determinants of human longevity: challenges and insights. Nat. Rev. Genet.

,

–

Cochran WG (

) Some methods for strengthening the common v

tests. Bio- metrics

,

–

Deelen J, Beekman M, Uh HW, Helmer Q, Kuningas M, Christiansen L, Kremer D, van der Breggen R, Suchiman HE, Lakenberg N, van den Akker EB, Passto- ors WM, Tiemeier H, van Heemst D, de Craen AJ, Rivadeneira F, de Geus EJ, Perola M, van der Ouderaa FJ, Gunn DA, Boomsma DI, Uitterlinden AG, Chris- tensen K, van Duijn CM, Heijmans BT, Houwing-Duistermaat JJ, Westendorp RG, Slagboom PE (