Nybo, H., Petersen, H.C., Gaist, D., Jeune, B., Andersen, K., McGue, M., Vaupel, J.W., Christensen, K., 2003. Predictors of mortality in 2,249 nonagenarians – the

Danish

-Cohort Survey. Journal of the American Geriatrics Society

(

),

–

Pedersen, C.B., Gøtzsche, H., Møller, J.O., Mortensen, P.B.,

The Danish Civil Registration System. A cohort of eight million persons. Danish Medical Bulletin

(

),

–

Perneger, T.V.,

What’s wrong with Bonferroni adjustments. British Medical Journal

(

),

–

Rantanen, T., Guralnik, J.M., Foley, D., Masaki, K., Leveille, S., Curb, J.D., White, L.,

Midlife hand grip strength as a predictor of old age disability. Journal of the American Medical Association

(

),

–

Ricquier, D., Miroux, B., Larose, M., Cassard-Doulcier, A.M., Bouillaud, F.,

Endocrine regulation of uncoupling proteins and energy expenditure. Interna- tional Journal of Obesity and Related Metabolic Disorders

,

–

Rose, G., Crocco, P., De Rango, F., Montesanto, A., Passarino, G.,

a. Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity. PL

One

(

), e

Rose, G., Crocco, P., D’Aquila, P., Montesanto, A., Bellizzi, D., Passarino, G.,

b. Two variants located in the upstream enhancer region of human UCP

gene affect gene expression and are correlated with human longevity. Experimental Gerontology

(

),

–

Roth, S.M., Schrager, M.A., Ferrell, R.E., Riechman, S.E., Metter, E.J., Lynch, N.A., Lindle, R.S., Hurley, B.F.,

CNTF genotype is associated with muscular strength and quality in humans across the adult age span. Journal of Applied Physiology

(

),

–

Salopuro, T., Pulkkinen, L., Lindstro¨m, J., Kolehmainen, M., Tolppanen, A.M., Eriks- son, J.G., Valle, T.T., Aunola, S., Ilanne-Parikka, P., Keina¨nen-Kiukaanniemi, S., Tuomilehto, J., Laakso, M., Uusitupa, M.,

Variation in the UCP

and UCP

genesassociateswithabdominalobesityandserumlipids:th

innis

iabetes Prevention Study. BMC Medical Genetics

,

Schaid,D.J.,Rowland,C.M.,Tines,D.E.,Jacobson,R.M.,Poland,G.A.,

Scoretests for association between traits and haplotypes when linkage phase is ambigu- ous. American Journal of Human Genetics

(

),

–

Schoenfeld, D.,

Partial residuals for the proportional hazards regression model. Biometrika

,

–

Schrager, M., Bandinelli, S., Maggi, S., Ferrucci, L.,

Sarcopenia: twenty questions for a research agenda. Basic and Applied Myology

(

), Sinnwell, J.P., Schaid, D.J.,

haplo.stats: Statistical Analysis of with Traits and Covariates when Linkage Phase is Ambiguous. R Version

. Soerensen, M., Dato, S., Tan, Q., Thinggaard, M., Kleindorp, R., Beekman, M., man, H.E.D., Jacobsen, R., M

ue, M., Stevnsner, T., Bohr, V.A., de Craen, Westendorp, R.G.J., Schreiber, S., Slagboom, E., Nebel, A., Christensen, K., tiansen, L.,

Common genetic variation in the GH-IGF-

-insulin DNA damage signalling and repair and pro-antioxidant pathways is with human longevity. Experimental Gerontology

(

),

–

Swindell, W.R.,

Accelerated failure time models provide a useful framework for aging research. Experimental Gerontology

,

–

van Abeelen, A.F., de Krom, M., Hendriks, J., Grobbee, D.E., Adan, R.A., van Schouw, Y.T.,

Variations in the uncoupling protein-

gene are with specific obesity phenotypes. European Journal of Endocrinology

–

(Erratum in: European Journal of Endocrinology

,

(

), T.B., Devaney, J.M., Pescatello, L.S.,

CNTF

G -> A polymorphism the muscle strength response to resistance training. Journal of Applied ology

(

),

–

Weir, B.S.,

Genetic Data Analysis II: Methods for Discrete Population Data. Sinauer Associates, Sunderland. Windelinckx, A., De Mars, G., Huygens, W., Peeters, M.W., Vincent, B., C., Lambrechts, D., Delecluse, C., Roth, S.M., Metter, E.J., Ferrucci, L., J., Vlietinck, R., Beunen, G.P., Thomis, M.A.,

Comprehensive fine ping of chr

q

-

and follow-up replication identify activin receptor (ACVR

B) as a muscle strength gene. European Journal of Human Genetics (

),

–

Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, Cinti, S., Lowell, B., Scarpulla, R.C., Spiegelman, B.M.,

Mechanisms trolling mitochondrial biogenesis and respiration through the coactivator PGC-

Cell

(

),

–