Acknowledgments: The generous support of Fondazione ART per la Ricerca sui Trapianti ONLUS (Milan, Italy) and Fondazione Aiuti per la Ricerca sulle Malattie Rare, Bergamo, Italy, and Istituto Edizioni ATLAS SpA, Bergamo, Italy is acknowledged. The authors thank the Istituto Italiano Edizioni ATLAS S.p.A for the grant for printing color figures. The authors are indebted to Dr. Rossella Piras, recipient of a fellowship from Fondazione ART, for invaluable help in gene sequencing and to Dr. Antonietta Chianca, Ph.D., for ELRM analysis.

References:
Alba G, El Bekay R, Chacon P, Reyes ME, Ramos E, Olivan J, Jimenez J, Lopez JM, Martin-Nieto J, Pintado E, Sobrino F (2004) Heme oxygenase-1 expression is down-regulated by angiotensin II and under hypertension in human neutrophils. J Leukoc Biol 76(2):427–434. doi: 10.1189/jlb.1103594

Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21(2):263–265. doi: 10.1093/bioinformatics/bth457

Benigni A, Cassis P, Remuzzi G (2010) Angiotensin II revisited: new roles in inflammation, immunology and aging. EMBO Mol Med 2(7):247–257. doi: 10.1002/emmm.201000080

Bilal E, Rabadan R, Alexe G, Fuku N, Ueno H, Nishigaki Y, Fujita Y, Ito M, Arai Y, Hirose N, Ruckenstein A, Bhanot G, Tanaka M (2008) Mitochondrial DNA haplogroup D4a is a marker for extreme longevity in Japan. PLoS One 3(6):e2421. doi: 10.1371/journal.pone.0002421

Corder EH, Lannfelt L, Basun H (1995) Apolipoprotein E genotype and the rate of decline in probable Alzheimer disease. Arch Neurol 52(8):702–708.

de Cavanagh EM, Inserra F, Ferder M, Ferder L (2011) From mitochondria to disease: role of the renin-angiotensin system. Am J Nephrol 34(6):545–553. doi: 10.1159/000334684

Erdmann J, Riedel K, Rohde K, Folgmann I, Wienker T, Fleck E, Regitz-Zagrosek V (1998) Characterization of polymorphisms in the promoter of the human angiotensin II subtype 1 (AT1) receptor gene. Ann Hum Genet 62(Pt 4):293–301.

Gu D, Kelly TN, Hixson JE, Chen J, Liu D, Chen JC, Rao DC, Mu J, Ma J, Jaquish CE, Rice TK, Gu C, Hamm LL, Whelton PK, He J (2010) Genetic variants in the renin-angiotensin-aldosterone system and salt sensitivity of blood pressure. J Hypertens 28(6):1210–1219. doi: 10.1097/HJH.0b013e328338e8d6

Guasti L, Marino F, Cosentino M, Maio RC, Rasini E, Ferrari M, Castiglioni L, Klersy C, Gaudio G, Grandi AM, Lecchini S, Venco A (2008) Prolonged statin-associated reduction in neutrophil reactive oxygen species and angiotensin II type 1 receptor expression: 1-year follow-up. Eur Heart J 29(9):1118–1126. doi:BK () The structure and function of G-protein-coupled receptors. Nature (): doi: /nature
Sethupathy P, Borel C, Gagnebin M, Grant GR, Deutsch S, Elton TS, Hatzigeorgiou AG, Antonarakis SE () Human microRNA on chromosome differentially interacts with its polymorphic target in the AGTR untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes. Am J Hum Genet (): doi: /
Sirtori CR, Calabresi L, Franceschini G, Baldassarre D, Amato M, Johansson J, Salvetti M, Monteduro C, Zulli R, Muiesan ML, Agabiti-Rosei E () Cardiovascular status of carriers of the apolipoprotein A-I(Milano) mutant: the Limone sul Garda study. Circulation (): 
Sunyaev S, Ramensky V, Koch I, Lathe Wrd, Kondrashov AS, Bork P () Prediction of deleterious human alleles. Hum Mol Genet (): 
Willcox BJ, Donlon TA, He Q, Chen R, Grove JS, Yano K, Masaki KH, Willcox DC, Rodriguez B, Curb JD () FOXOA genotype is strongly associated with human longevity. Proc Natl Acad Sci U S A (): doi: /pnas.
Wilson SK () Role of oxygen-derived free radicals in acute angiotensin II-induced hypertensive vascular disease in the rat. Circ Res (): 
Zamar D, Brad Meme y, Graham J () elrm: software implementing exact-like inference for logistic regression models. J Stat Softw ()