References:
[1] M. McGue, J.W. Vaupel, N. Holm, B. Harvald, Longevity is moderately heritable in a sample of Danish twins born between 1870-1880, J. Gerontol. 48 (1993) B237-B244.
[2] A.M. Herskind, M. McGue, N.V. Holm, T.I. Sorensen, B. Harvald, J.W. Vaupel, The heritability of human longevity: a population-based study of 2872 Danish twin pairs born between 1870 and 1900, Hum. Genet.
[3] T.T. Perls, J.Wilmoth, R.Levenson, M.Drinkwater, M.Cohen,H.Bogan,E.Joyce,S.Brewster,L.Kunkel,A.Puca, Life-long sustained mortality advantage of siblings of centenarians, Proc. Natl. Acad. Sci. U.S.A.
[4] A.Skytthe,N.L.Pedersen,J.Kaprio,M.A.Stazi,J.V.Hjelmborg,I.Iachine,J.W.Vaupel,K.Christensen,Longevity studies in GenomEUtwin,Twin Res.
[5] J.v.B.Hjelmborg,I.Iachine,A.Skytthe,J.W.Vaupel,M.McGue,M.Koskenvuo,J.Kaprio,N.L.Pedersen,K.Christensen,Genetic influence on human lifespan and longevity, Hum.Genet.
[6] F.Schchter,L.Faure-Delanef,F.Guenot,H.Rouger,P.Froguel,L.Lesueur-Ginot,D.Cohen,Genetic associations with human longevity at the APOE and ACE loci, Nat. Genet.
[7] T.Perls,L.M.Kunkel,A.A.Puca,The genetics of exceptional human longevity, J. Am. Geriatr. Soc.
[8] T.B.Kirkwood,S.N.Austad,Why do we age? Nature
[9] L.Partridge,D.Gems,Mechanisms of ageing: public or private? Nat. Rev. Genet.
[10] E.D.Smith,M.Tsuchiya,L.A.Fox,N.Dang,D.Hu,E.O.Kerr,E.D.Johnston,B.N.Tchao,D.N.Pak,K.L.Welton,D.E.L.Promislow,J.H.Thomas,M.Kaeberlein,B.K.Kennedy,Quantitative evidence for conserved longevity pathways between divergent eukaryotic species, Genome Res.
[11] L.Guarente,Aging, What makes us tick? Science
[12] M.Kuningas,S.P.Mooijaart,D.van Heemst,B.J.Zwaan,P.E.Slagboom,R.G.Westendorp,Genes encoding longevity: from model organisms to humans, Aging Cell
[13] S.I.Rattan,Theories of biological aging: genes, proteins, and free radicals, Free Radic. Res.
[14] C.Kenyon,J.Chang,E.Gensch,A.Rudner,R.Tabtiang,A.C.elegans mutant that lives twice as long as wild type, Nature
[15] V.T.Mihaylova,C.Z.Borland,L.Manjarrez,M.J.Stern,H.Sun,The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway, Proc. Natl. Acad. Sci. U.S.A.
[16] D.S.Hwangbo,B.Gershman,M.P.Tu,M.Palmer,M.Tatar,Drosophila FOXO controls lifespan and regulates insulin signaling in brain and fat body, Nature
[17] K.Christensen,T.E.Johnson,J.W.Vaupel,The quest for genetic determinants of human longevity: challenges and insights, Nat. Rev. Genet.
[18] C.V.Anselmi,A.Malovini,R.Roncarati,V.Novelli,F.Villa,G.Condorelli,R.Bellazzi,A.A.Puca,Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study, Rejuvenation Res.
[19] F.Flachsbart,A.Caliebe,R.Kleindorp,H.Blanche,H.von Eller-Eberstein,S.Nikolaus,S.Schreiber,A.Nebel,Association of FOXO3A variation with human longevity confirmed in German centenarians, Proc. Natl. Acad. Sci. U.SBrown, L. Thomas, M.A. Ferreira, D. Bender, J. Maller, P. Sklar, P.I. de Bakker, M.J. Daly, P.C. Sham, PLINK: a tool set for whole-genome association and population-based linkage analyses, Am.J.Hum.Genet. [ ] W.D. Dupont, W.D. Plummer., Power and sample size calculations for studies involving linear regression, Control. Clin. Trials [ ] Y. Benjamini, A.M. Krieger, D. Yekutieli, Adaptive linear step-up procedures that control the false discovery rate, Biometrika [ ] R Development Core Team, A language and environment for statistical computing, R Foundation for Statistical Computing, Vienna, Austria, ISBN - - - ( ) URL http://www.R-project.org. [ ] R.A. Ihrie, E. Reczek, J.S. Horner, L. Khachatrian, J. Sage, T. Jacks, L.D. Attardi, PERP is a mediator of p53-dependent apoptosis in diverse cell types,Curr.Biol.[ ] F. Liu, C.F. Lo, X. Ning, E.M. Kajkowski, M.Jin,C.Chiriac,C.Gonzales,S.Naureckiene,Y.-W.Lock,K.Pong,M.M.Zaleska,J.S.Jacobsen,S.Silverman,B.A.Ozenberger,
Expression of NALP in cerebellar granule neurons stimulates apoptosis,
Cell.Signal.[ ] L.Rossig,J.Haendeler,C.Hermann,P.Malchow,C.Urbich,A.M.Zeiher,S.Dimmeler,Nitric oxide down-regulates MKP-  NA levels,J.Biol.Chem.[ ] L.A.Groom,A.A.Sneddon,D.R.Alessi,S.Dowd,S.M.Keyse,Differential regulation of the MAP, SAP and RK/p kinases by Pyst, a novel cytosolic dual-specificity phosphatase, Embo J. [ ] R. Seger, E. Krebs, The MAPK signaling cascade, FASEB J. [ ] N.A. Zeliadt, L.J. Mauro, E.V. Wattenberg, Reciprocal regulation of extracellular signal-regulated kinase/ and mitogen-activated protein kinase phosphatase- , Toxicol. Appl. Pharmacol.[ ] D.W. Chan, V.W.S. Liu, G.S.W. Tsao, K.-M. Yao, T. Furukawa, K.K.L.Chan,H.Y.S.Ngan,
Loss of KP mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells,Carcinogenesis[ ] K.Okudela,T.Yazawa,T.Woo,M.Sakaeda,J.Ishii,H.Mitsui,H.Shimoyamada,H.Sato,M.Tajiri,N.Ogawa,M.Masuda,T.Takahashi,H.Sugimura,H.Kita-
mura,
Down-regulation of DUSP expression in lung cancer: its mechanism and potential role in carcinogenesis, Am.J.Pathol.[ ] S.Xu,T.Furukawa,N.Kanai,M.Sunamura,A.Horii,
Abrogation of DUSP by hypermethylation in human pancreatic cancer,J.Hum.Genet.[ ] T.Furukawa,M.Sunamura,A.Horii,Molecular mechanisms of pancreatic carcinogenesis,Cancer Sci.[ ] L.D.Attardi,E.E.Reczek,C.Cosmas,E.G.Demicco,M.E.Murrach,S.W.Lowe,T.Jacks,
PERP is an apoptosis-associated target of p53 and is a novel member of the PMP-/gas family,Gen. Dev.[ ] L.Davies,D.Gray,D.Spiller,M.R.H.White,B.Damato,I.Grierson,L.Paraoan,
PERP apoptosis mediator: localization, function and caspase activation in uveal melanoma,J.Cell.Mol.Med.[ ] T.Hildebrandt,J.Preiherr,N.Tarbe,S.Klostermann,G.N.Vaujien,U.H.Weid-
le, Identification of THW, a putative new tumor suppressor gene,Anticancer Res.[ ] L.Paraoan,D.Gray,P.Hiscott,B.Ebrahimi,B.Damato,I.Grierson,