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Acknowledgements

We thank all participants of the Leiden Longevity Study. The research leading to these results has received funding from the European Union’s Seventh Framework Programme (FP7/2007-2011) under grant agree- ment no. 259679. This study was supported by a grant from the Innovation-Oriented Research Program on Genomics (SenterNovem IGE05007), the Centre for Medical Systems Biology, the Netherlands Consortium for Healthy Ageing (Grant 050-060-810), all in the framework of the Netherlands Genomics Initiative, the Netherlands Organization for Scientific Research (NWO) and by Unilever Colworth. David A. Gunn is employed by Unilever PLC and involved in the design, data collection and analysis as well as the decision to publish.

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Author contributions

WMP, MB and PES designed the experiments, interpreted data and wrote the paper. WMP, JD, RB, BG and ED performed the experiments and analysed data. DH, AJMC and PES generated the study concept and study design. GP contributed to the study concept, interpretation of data and revised the paper.

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