:

–

Youngma

D,Par

Y,Ame

N(

)Proteinoxidationassociatedwithagingisreduced by dietary restriction of protein or calories. Proc Natl Acad Sci USA

:

–

Heilbronn LK, et al. (

) Effect of

-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: A randomized controlled trial. JAMA

:

–

Selman C, et al. (

) Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate

null mice. FASEB J

:

–

Murph

T,etal.(

)Genesthatactdownstreamo

AF-

toinfluencethelifespan of Caenorhabditis elegans. Nature

:

–

Kuningas M, et al. (

) SIRT

gene, age-related diseases, and mortality: The Leiden

-plus study. J Gerontol A Biol Sci Med Sci

:

–

Kagan A. Ed (

) The Honolulu Heart Program (Harwood Academic, Amsterdam, The Netherlands).

Worth RM, Kagan A (

) Ascertainment of men of Japanese ancestry in Hawaii through World War II Selective Service registration. J Chronic Dis

:

–

Rodriguez BL, Curb JD (

) Cardiovascular risk factors in the elderly: The Honolulu Heart Program. Cardiovasc Risk Factors

:

–

White L, et al. (

) Prevalence of dementia in Japanese-American men living in Hawaii: The Honolulu-Asia Aging Study. JAMA

:

–

Nationa

nstituteso

ealth(NIH),U.S.Departmento

ealthan

uma

ervices,NIH, National Institute on Aging (

) Report of the National Institute on Aging Advisory Panel on Exceptional Longevity (APEL). NIH Pub

–

(NIH, Washington DC).

Arias E (

) United States life tables,

(National Center for Health Statistics, Hyattsville, MD), vol.

, no.

Nordyk

C,Le

,Gardne

W(

)Aprofileo

awaii’selderlypopulation.Papers East West Popul Inst

:

–

Mehta C, Patel N (

) Sta

act

(CYTEL Software Corporation, Cambridge, MA).

SAS Institute, Inc. (

) SAS/STAT user’s guide, version

(SAS Institute, Cary, NC).

study of

Danish twin pairs born

–

Hum Genet

:

–

Yashin AI, Iachine IA, Harris JR (

) Half of variation in susceptibility to mortality genetic: Findings from Swedish twin survival data. Behav Genet

:

–

Christensen K, Johnson TE, Vaupel JW (

) The quest for genetic determinants human longevity: challenges and insights. Nat Rev Genet

:

–

Willcox DC, Willcox BJ, Hsueh WC, Suzuki M (

) Genetic determinants exceptional human longevity. AGE

:

–

Bishop NA, Guarente L (

) Genetic links between diet and lifespan: Shared anisms from yeast to humans. Nat Rev Genet

:

–

in humans. Science

:

–

Gundmundsson H, et al. (

) Inheritance of human longevity in Iceland. Eur J Genet

:

–

Kerber RA, O’Brien E, Smith KR, Cawthon RM (

) Familial excess longevity in genealogies. J Gerontol A Biol Sci Med Sci

:B

–B

Perls TT, et al. (

) Life-long sustained mortality advantage of siblings of ians. Proc Natl Acad Sci USA

:

–

Willcox BJ, Willcox DC, He Q, Curb JD, Suzuki M (

) Siblings of Okinawan narians exhibit lifelong mortality advantages. J Gerontol A Biol Med Sci

Partridge L (

) Some highlights of research on aging with invertebrates,

Aging Cell

:

–

Ghazi A, Henis-Korenblit S, Kenyon C (

) Regulation of Caenorhabditis lifespan by a proteasomal E

ligase complex. Proc Natl Acad Sci USA

Bartke A (

) New findings in gene knockout, mutant and transgenic mice. Gerontol

:

–

that can function to double the life-span of C. elegans. Science

:

–

Brunet A, et al. (

) Stress-dependent regulation of FOXO transcription factors the FOXO deacetylase. Science

:

–

Kenyon C, Murphy CT (

) Enrichment of regulatory motifs upstream of DAF-

targets. Nat Genet

:

–

van der Horst A, Burgering BM (

) Stressing the role of FOXO proteins in and disease. Nat Rev Mol Cell Biol

:

–

Russell SJ, Kahn CR (

) Endocrine regulation of ageing. Nat Rev Mol Cell

:

–

Sauve AA, Wolberger C, Schramm VL, Boeke JD (

) The biochemistry of Annu Rev Biochem

:

–

Caenorhabditis elegans. Nature

:

–

Blu¨her M, Kahn BB, Kahn CR (

) Extended longevity in mice lacking the receptor in adipose tissue. Science

:

–

Bartke A (

) Impact of reduced insulin-like growth factor-

/insulin signaling aging in mammals: novel findings. Aging Cell

:

–

White MF (

) Insulin signaling in health and disease. Science

:

–

Conover CA, Bale LK (

) Loss of pregnancy-associated plasma protein A lifespan in mice. Aging Cell

:

–

Curran SP, Ruvkun G (

) Lifespan regulation by evolutionarily conserved essential for viability. PL

Genet

:e

Greer EL, et al. (

) An AMPK-FOXO pathway mediates the extension of

with

–

-

proteinstoactivat

AF-

andextendlifespan.Cell

:

–

span in C. elegans. Science

:

–

Hsu AL, Murphy CT, Kenyon C (

) Regulation of aging and age-related disease DAF-

and heat-shock factor. Science

:

–

Murphy CT (

) The search for DAF-

/FOXO transcriptional targets: and discoveries. Exp Gerontol

:

–

Wang MC, Bohmann D, Jasper H (

) JNK extends lifespan and limits growth

Giannakou ME, et al. (

) Dynamics of the action of

OXO on adult mortality Drosophila. Aging Cell

:

–

Harman D (

) Aging: A theory based on free radical and radiation Gerontol

:

–

Beckman KB, Ames BN (

) The free radical theory of aging matures. Physiol

:

–

tation on the aging process. Clin Interv Aging

:

–

Bonafe M, et al. (

) Polymorphic variants of IGF-I receptor and

68. Mehta C, Patel N (2001) StatXact 5 (CYTEL Software Corporation, Cambridge, MA). 69. SAS Institute, Inc. (1990) SAS/STAT user’s guide, version 6 (SAS Institute, Cary, NC).