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No differences were observed in the XbaI polymorphism of apo B gene between the various age groups. This finding is in accordance with the results of Thieszen et al., who studied 41 nona- genarians in Nebraska [27]. In contrast, the R- allele of the EcoRI polymorphism of apo B gene was less prevalent in the nonagenarian group than in the younger age groups. A correlation between the rare allele R- and an increased risk for CHD has been found in many studies [8,28], although no such association was observed in a recent survey of young myocardial infarction survivors [29]. At the moment there is no direct evidence that this DNA mutation is causally related to the pathogenesis of CHD. It may be noteworthy, however, that the prevalence of R- allele in the control groups of our study is higher than in the healthy populations reported from other countries, and approximately at the same level as among CHD patients in other populations [8,28]. Overall, these findings suggest that the R- allele may be a risk factor for CHD. In conclusion, nonagenarians have a low preva-

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