Structure of the human tyrosine hydroxylase gene: alternative splicing from a single gene accounts for generation of four

NA types. J. Biochem.

,

(cid:

)

/ M

ue, M., Vaupel, J.W., Holm, N., Harvald, B.,

Longevity is moderately heritable in a sample of Danish twins born

(cid:

)

J. Gerontol.

, B

(cid:

)B

/ / Meloni, R., Albanese, V., Ravassard, P., Treilhou, F., Mallet, J.,

A tetranucleotide polymorphic microsatellite,

On the whole, the results confirm that the biological background of the aging process is really complex, even if a single locus is considered. With more molecular data becoming available, we hope that the model here presented could help to locate important genes that reside in the genetic realm of human longevity.

Acknowledgements

This work was supported by the Italian Ministry of University and Technological and Scientific Research (COFIN 2000(cid:2)2000, Genetic Determi- / nants in Human Longevity), by the Italian Ministry of Health (IRCCS 2000(cid:2)2002, Marcatori genetici e / biologici di invecchiamento normale e patologico), by Istituto Nazionale Riposo Cura Anziani (IN-

Q. Tan et al. / Mechanisms of Ageing and Development 123 (2002) 1403(cid:2)1410 /

located in the first intron of the tyrosine hydroxylase gene, acts as a trascription regulatory element in vitro. Hum. Mol. Genet.

,

(cid:

)

/ Polymeropoulos, M.H., Xiao, H., Rath, D.S., Merril, C.R.,

Tetranucleotide repeat polymorphism at the human tyrosine hydroxylase gene (TH). Nucl. Acids Res.

,

Puca, A.A., Daly, M.J., Brewster, S.J., Matise, T.C., Barrett, J., Shea-Drinkwater, M., Kang, S., Joyce, E., Nicoli, J., Benson, E., Kunkel, L.M., Perls, T.,

A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome

Proc. Natl. Acad. Sci. USA

,

(cid:

)

/ Rahn, K.H., Barenbrock, M., Hausberg, M.,

The sympathetic nervous system in the pathogenesis of hyper- tension. J. Hypertens.

, S

(cid:

)S

/ Tan, Q., Yashin, A.I., De Benedictis, G., Cintolesi, F., Rose, G., Bonafe, M., Franceschi, C., Vach, W., Vaupel, J.W.,

A logistic regression model for measuring gene- longevity associations. Clin. Genet.

(

),

(cid:

)

/ Tan, Q., De Benedictis, G., Yashin, I.A., Bonafe, M., D

uca, M., Valensin, S., Vaupel, J.W., Franceschi, C.,

Measuring the genetic influence in modulating human life span: gene(cid:

)environment and gene(cid:

)sex interactions. Bioger- / / ontology

,

(cid:

)

/ Tan, Q., Yashin, A.I., Bladbjerg, E.M., de Maat, M.P., Andersen-Ranberg, K., Jeune, B., Christensen, K., Vaupel, J.W.,

Variations of cardiovascular disease associated genes exhibit sex-dependent influence on human longevity. Exp. Gerontol.

(

),

(cid:

)

/ Tan, Q., Yashin, I.A., Bladbjerg, E.M., Maat, P.M., Andersen- Ranberg, K., Jeune, B., Christensen, K., Vaupel, J.W.,

A case-only approach for assessing gene by sex interaction in human longevity. J. Gerontol. Biol. Sci., A Biol. Sci. Med. Sci.

(

), B

(cid:

)B

/ Tan, Q., De Benedictis, G., Ukraintseva, S.V., Franceschi, C., Vaupel, J.W., Yashin, A.I.,

A centenarian-only approach for assessing gene(cid:

)gene interaction in human / longevity. Eur. J. Hum. Genet.

(

),

(cid:

)

/ Vaupel, J.W., Yashin, A.I.,

Heterogeneity’s ruses: some surprising effects of selection on population dynamics. Am. Stat.

,

(cid:

)

/ Yashin, A.I., Vaupel, J.W., Andreev, K.F., Tan, Q., Iachine, I.A., Carotenuto, L., De Benedictis, G., Bonafe, M., Valensin, S., Franceschi, C.,

Combining genetic and demographic information in population studies of aging and longevity. J. Epidemiol. Biostatist.

,

(cid:

)

/ Yashin, A.I., Iachine, I.A., Harris, J.R.,

Half of the variation in susceptibility to mortality is genetic: find- ings from Swedish twin survival data. Behav. Genet.

,

(cid:

) /

Yashin, A.I., De Benedictis, G., Vaupel, J.W., Tan, Q., Andreev, K.F., Iachine, I.A., Bonafe, M., D

uca, M., Valensin, S., Carotenuto, L., Franceschi, C.,

Genes, demography, and life span: the contribution of demographic data in genetic studies on aging and longevity. Am. J. Hum. Genet.

,

(cid:

) /

Yashin, A.I., De Benedictis, G., Vaupel, J.W., Tan, Q., Andreev, K.F., Iachine, I.A., Bonafe, M., D

uca, M., Valensin, S., Carotenuto, L., Franceschi, C.,

Genes and longevity: lessons from studies on centenarians. J. Gerontol.

a, B

(cid:

)B

/