5. Conclusions 
To the best of our knowledge, this is the first study to simultaneously investigate the contribution of CETP and APOE polymorphisms to dyslipidemia in oldest-old females. Besides the traditional understanding of the association between CETP polymorphism and HDL-c, this study provided evidence of its effect on TG, at least in sub-populations. The results provide evidence of strong independent associations between hTG and CETP*V in the oldest-old Chinese females in this study, and APOE*4, as an independently non-significant variant, might interact with another variant resulting in an increased disease risk. Nevertheless, we fully expect that additional variants, some rare, will be added to the list of polymorphisms that influence healthy status and lifespan. It should be noted that this study was conducted based on a limited population because of the rare prevalence of oldest-old in Yongfu (0.0133%). Accordingly, our study is only a first step toward defining a genetic association with hTG in oldest-old Chinese women, and this has to be further replicated by long-term prospective studies with larger samples across genders. Supplementary data to this article can be found online at http://dx.doi.org/10.1016/j