Table 4

Metabolism phenotype based on mtDNA haplogroups F in Chuang population.

All Women Men F+ F− p value F+ F− p value F+ F− p value FBG (mmol/l) Long-lived 5.30±1.65 5.35±1.52 0.82 5.40±1.71 5.27±1.48 0.63 4.97±1.39 5.56±1.63 0.22 Younger 4.77±0.55 4.86±0.57 0.20 4.78±0.63 4.81±0.54 0.75 4.77±0.52 4.90±0.60 0.16 TG (mmol/l) Long-lived 1.37±1.03 1.37±0.91 0.99 1.29±0.93 1.45±0.95 0.27 1.67±1.35 1.14±0.75 0.19 Younger 1.53±0.43 1.51±0.45 0.70 1.53±0.43 1.49±0.46 0.70 1.54±0.45 1.53±0.45 0.88 TC (mmol/l) Long-lived 4.88±1.27 5.03±1.14 0.41 4.98±1.25 5.16±1.05 0.38 4.55±1.35 4.61±1.27 0.88 Younger 4.54±0.76 4.62±0.73 0.41 4.39±0.81 4.59±0.70 0.20 4.62±0.74 4.64±0.74 0.86 HDL-c (mmol/l) Long-lived 1.68±0.72 1.48±0.57 0.02 1.74±0.69 1.52±0.59 0.03 1.44±0.81 1.35±0.50 0.62 Younger 1.47±0.25 1.51±0.35 0.44 1.42±0.29 1.50±0.27 0.23 1.50±0.23 1.51±0.40 0.77 LDL-c (mmol/l) Long-lived 2.84±0.76 2.86±0.95 0.86 2.90±0.76 2.90±0.93 0.97 2.60±0.75 2.76±1.00 0.60 Younger 2.22±0.57 2.26±0.61 0.63 2.29±0.67 2.23±0.58 0.93 2.21±0.52 2.28±0.63 0.49

Note: Data in italics indicates pb0.05; F+ indicated subjects with haplogroup F, and F− suggested subjects without haplogroup F. FBG = fasting blood glucose, TG = serum total triglyceride, TC = serum total cholesterol, HDL-c = High density lipoprotein-cholesterol, LDL-c = Low density lipoprotein-cholesterol.

trait expression. Further study of these factors could be important to obtain a clearer relationship of mtDNA variations with longevity. Supplementary materials related to this article can be found online

on successful aging may be explained by decreased production of ROS from mitochondria. Further studies are needed to examine whether the production of superoxides or ROS from cybrids carrying mtDNA of haplogroup F is actually lower than that in cybrid carrying mtDNA of other haplogroups. However, the actual effect of the mtSNP m.13928GNC on mitochondrial function remains to be examined.

doi:10.1016/j.exger.2011.09.001.

Conflict of interest

In the present study, haplogroup F was shown to be with longevity in females, whereas no such significant was found in males. Although the male group is small in size in the gender-stratified analyses, previous studies have that women live longer than men and the effect of genetic on successful aging is different between females and males et al., 2010). The gender difference in the association of the logroup with longevity may be attributable to the difference of iological background such as sex hormones and extrinsic factors as smoking, etc. (Candore et al., 2006; Ordovas, 2007). These ences might explain the present observation that women but men were distinctly influenced by the differences among drial haplogroup. Therefore, our results suggest a possible that the haplogroup F has the protective effect only on women, men. In addition, our analysis indicated subhaplogroup F3 in branch level of haplogroup F was associated with longevity and cessful aging in female subjects. However, in the present study, frequency of subhaplogroup F3 is very low (4.9% in long-lived lations and 3.0% in controls), the power in genetic association would thus fall off for this low frequency. Therefore, the association subhaplogroup F3 with longevity needs to be ascertained by tion in larger sample sizes.

None of the authors has conflict of interest.

Acknowledgments

The authors thank the subjects for donating DNA samples. The study is supported partly by National Scientific Foundation of China (30972709, 30671110) and National Basic Research Program of China (973 Program) (2006CB503901) grants to Z.Y.

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