Table 1. Association Statistics for 56 SNPs Located in the CYP2C Gene Region (for the centenarian subset)
Position on CHR 10	Gene	SNP (GRCh37/hg19)	Min AF Cases	Min AF Controls	p	Bonferroni-Adjusted p CCA	CCA
CYP2C18	rs10736086	96441650	.489	.503	.45	1
rs12249418	96442917	.242	.215	.08	1
rs1575934	96445609	.464	.448	.36	1
rs7896133	96464730	.059	.069	.24	1
rs11188059	96468899	.106	.131	.04	Bold indicates SNP showed a nominally significant association signal in the analysis of the centenarian sample but did not pass correction for multiple testing.
rs7914753	96486504	.464	.448	.36	1
rs2281891	96493058	.164	.164	.99	1
rs1042192 96495284 .166 .167 .Characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and IL mutant forms. Arch Biochem Biophys.;  :  Rettie AE, Wienkers LC, Gonzalez FJ, Trager WF, Korzekwa KR. Impaired (S)-warfarin metabolism catalyzed by the RC allelic variant of CYP C. Pharmacogenetics.;  :  Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics.;  :  Flachsbart F, Caliebe A, Kleindorp R, et al. Association of FOXO A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci U S A.;  :  Flachsbart F, Caliebe A, Nothnagel M, et al. Depletion of potential AM risk haplotype for Alzheimer's disease in long-lived individuals. Eur J Hum Genet.;  :  Nebel A, Flachsbart F, Till A, et al. A functional EXO promoter variant is associated with prolonged life expectancy in centenarians. Mech Ageing Dev.;  :  Pawlikowska L, Hu D, Huntsman S, et al. Association of common genetic variation in the insulin/IGF signaling pathway with human longevity. Aging Cell.;  :  The effect of rare variants should be statistically detectable as these effects ought to be carried by one of the common background haplotypes (59). Furthermore, common variants can act as significant modifiers of the effects of rare variants (60). Thus, rare variants that are functionally relevant are often identified by common variant associations (61-64). Altogether, it seems unlikely that we have missed such rare variant effects in our comprehensive approach. The possibility that the negative association finding is due to population stratification in our samples is also rather improbable because the validity and efficacy of our large and well-characterized study population for genetic longevity research have already been shown with the identification and validation of previous association findings (26, 32-34). Overall, our results suggest that there is no noteworthy influence of sequence variation in the CYP2C genes on human longevity in Germans. Funding This study was supported by the Faculty of Medicine (intramural research support), Christian-Albrechts-University Kiel; and the DFG Excellence Cluster Inflammation at Interfaces. Acknowledgments We thank all study participants for their cooperation. For excellent technical assistance, we wish to acknowledge the laboratory personnel of the Institute of Clinical Molecular Biology and the members of the Popgen Biobank. Herskind AM, Mue M, Holm NV, Sorensen TI, Harvald B, Vaupel JW. The heritability of human longevity: a population-based study of Danish twin pairs born. Hum Genet.;  :  Finch CE, Tanzi RE. Genetics of aging. Science.;  :  Ljungquist B, Berg S, Lanke J, Mlearn GE, Pedersen NL. The effect of genetic factors for longevity: a comparison of identical and fraternal twins in the Swedish Twin Registry. J Gerontol A Med Sci.;  :  Skytthe A, Pedersen NL, Kaprio J, et al. Longevity studies in GenoUtwin. Twin Res.;  :  Gogele M, Pattaro C, Fuchsberger C, Minelli C, Pramstaller PP, Wjst M. Heritability analysis of life span in a semi-isolated population followed across four centuries reveals the presence of pleiotropy between life span and reproduction. J Gerontol A Biol Sci Med Sci.;  :  Hjelmborg J, Iachine I, Skytthe A, et al. Genetic influence on human lifespan and longevity. Hum Genet.;  :  Franceschi C, Bonaf M. Centenarians as a model for healthy aging. Biochem Soc Trans.;  :  Perls TT. The different paths to. Am J Clin Nutr.;  :  Perls T, Kunkel LM, Puca AA. The genetics of exceptional human longevity. J Am Geriatr Soc.;  :  Johnson TE. Genes, phenes, and dreams of immortality: the Kleemeier Award lecture. J Gerontol A Biol Sci Med Sci.;  :  Guengerich FP. Cytochrome Ps and other enzymes in drug metabolism and toxicity. AAPS J.;  :E  Murray CJ, Lopez AD. Evidence-based health policies-lessons from the Global Burden of Disease Study. Science.;  :  Deelen J, Beekman M, Uh HW, et al. Genome-wide association study identifies a single major locus contributing to survival into old age;I'm sorry, there is no text enclosed in ``` ```. Please provide the text that needs to be proofread and improved.