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Shoenfeld Y, Tincani A, Gershwin ME. Sex gender and autoimmunity.

Downloaded from http://biomedgerontology.oxfordjournals.org/ at Univ of Iowa-Law Library on August 8, 2015

In conclusion, the discrepancies among the results obtained on rs1042522 for longevity in different popula- tions could result from the pleiotropic effects of p53 and the potential ethnic variation of its functional variants. The gen- der-specific association of rs1042522 with life expectancy clearly claims for future investigations. Manipulating p53 expression in mouse models in p53 dose–specific, mouse tissue–specific, developmental stage–specific, and sex-spe- cific manners may further shed light on the role of p53 in aging and longevity in mammals (5). Thus, only a wider analysis of genetic and environmental factors influencing p53 pathway could definitively address the role of p53 pro- tein in human longevity.

Funding

This work was supported by Italian Ministry for University, Scientific Research and Technology (PRIN 2008—prot. 20089MANHH_002).

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