,

–

Berthold, H.K., Giannakidou, E., Krone, W., Tregouet, D.A., Gouni-Berthold, I.,

In- fluence of ghrelin gene polymorphisms on hypertension and atherosclerotic dis- ease. Hypertens. Res.

,

–

Kawano, T., Ito, Y., Ishiguro, M., Takuwa, K., Nakajima, T., Kimura, Y., 2000. Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans. Biochem. Biophys. Res. Commun. 273, 431–436. Kenyon, C.J., 2010. The genetics of ageing. Nature 464, 504–512.

(

)

–

Pedersen, C.B., Gotzsche, H., Moller, J.O., Mortensen, P.B.,

The Danish Civil tration System. A cohort of eight million persons. Dan. Med. Bull.

,

–

Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M.A.R., Bender, D., Maller, Sklar, P., de Bakker, P.I.W., Daly, M.J., Sham, P.C.,

PLINK: a toolset for genome association and population-based linkage analysis. Am. J. Hum. Genet. Scarpaci, S., Frasca, D., Barattini, P., Guidi, L., Doria, G.,

DNA damage and repair capacities in human naive and memory T cells from peripheral of young and elderly subjects. Mech. Ageing Dev.

,

–

Schildkraut, J.M., Iversen, E.S., Wilson, M.A., Clyde, M.A., Moorman, P.G., Palmieri, Whitaker, R., Bentley, R.C., Marks, J.R., Berchuck, A.,

Association DNA damage response and repair genes and risk of invasive serous ovarian PL

One

, e

Shih, D.M., Gu, L., Xia, Y.R., Navab, M., Li, W.F., Hama, S., Castellani, L.W., Furlong, Costa, L.G., Fogelman, A.M., Lusis, A.J.,

Mice lacking serum paraoxonase susceptible to organophosphate toxicity and atherosclerosis. Nature

, Skytthe, A., Kyvik, K., Holm, N.V., Vaupel, J.W., Christensen, K.,

The Danish Registry:

birth cohorts of twins. Twin Res.

,

–

Soerensen, M., Dato, S., Christensen, K., M

ue, M., Stevnsner, T., Bohr, Christiansen, L.,

Replication of an association of variation in the gene with human longevity using both case–control and longitudinal data. Cell

,

–

Tyner, S.D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, Soron, G., Cooper, B., Brayton, C., Hee, P.S., Thompson, T., Karsenty, G., Bradley, Donehower, L.A.,

p

mutant mice that display early ageing-associated notypes. Nature

,

–

van der Horst, G.T., van, S.H., Berg, R.J., van Gool, A.J., de, W.J., Weeda, G., Morreau, Beems, R.B., van Kreijl, C.F., de Gruijl, F.R., Bootsma, D., Hoeijmakers, J.H.,

fective transcription-coupled repair in Cockayne syndrome B mice is with skin cancer predisposition. Cell

,

–

van Heemst, D., Beekman, M., Mooijaart, S.P., Heijmans, B.T., Brandt, B.W., Zwaan, Slagboom, P.E., Westendorp, R.G.,

a. Reduced insulin/IGF-

signalling human longevity. Aging Cell

,

–

van Heemst, D., Mooijaart, S.P., Beekman, M., Schreuder, J., de Craen, A.J., Brandt, Slagboom, P.E., Westendorp, R.G.,

b. Variation in the human TP

gene old age survival and cancer mortality. Exp. Gerontol.

,

–

Van Ness, B., Ramos, C., Haznadar, M., Hoering, A., Haessler, J., Crowley, J., Jacobus, Oken, M., Rajkumar, V., Greipp, P., Barlogie, B., Durie, B., Katz, M., Atluri, G., G., Gupta, R., Steinbach, M., Kumar, V., Mushlin, R., Johnson, D., Morgan, G., Genomic variation in myeloma: design, content, and initial application of Bank On A Cure SNP Panel to detect associations with progression-free BMC Med.

,

Willcox, B.J., Donlon, T.A., He, Q., Chen, R., Grove, J.S., Yano, K., Masaki, K.H., D.C., Rodriguez, B., Curb, J.D.,

a. FOXO

A genotype is strongly with human longevity. Proc. Natl. Acad. Sci.

,

–

Yang, X.R., Pfeiffer, R.M., Wheeler, W., Yeager, M., Chanock, S., Tucker, M.A., A.M.,

Identification of modifier genes for cutaneous malignant melanoma melanoma-prone families with and without CDKN

A mutations. Int. J. Cancer

–

Yashin, A.I., De, B.G., Vaupel, J.W., Tan, Q., Andreev, K.F., Iachine, I.A., Bon

e, Valensin, S., De, L.M., Carotenuto, L., Franceschi, C.,

Genes and longevity: sons from studies of centenarians. J. Gerontol. A Biol. Sci. Med. Sci.

, Yashin, A.I., Wu, D., Arbeev, K.G., Ukraintseva, S.V.,

Joint influence of genetic variants on human longevity. Aging (Albany NY)

,

–

M. Soerensen et al. / between the MLH

gene and longevity. Hum. Genet.

,

–

Kuningas, M., Mooijaart, S.P., van, H.D., Zwaan, B.J., Slagboom, P.E., Westendorp,

Genes encoding longevity: from model organisms to humans. Aging Cell

–

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Kurabayashi, M., Kaname, T., Kume, E., Iwasaki, H., Iida, A., Shiraki-Iida, Nishikawa, S., Nagai, R., Nabeshima, Y.I.,

Mutation of the mouse gene leads to a syndrome resembling ageing. Nature

,

–

Kurosu, H., Yamamoto, M., Clark, J.D., Pastor, J.V., Nandi, A., Gurnani, P., O.P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., Shimomura, I., Takayama, Herz, J., Kahn, C.R., Rosenblatt, K.P., Kuro-o, M.,

Suppression of aging mice by the hormone Klotho. Science

,

–

Li, Y., Wang, W.J., Cao, H., Lu, J., Wu, C., Hu, F.Y., Guo, J., Zhao, L., Yang, F., Zhang, Y.X., W., Zheng, G.Y., Cui, H., Chen, X., Zhu, Z., He, H., Dong, B., Mo, X., Zeng, Y., Tian,

Genetic association of FOXO

A and FOXO

A with longevity trait in Han nese populations. Hum. Mol. Genet.

,

–

Lunetta, K.L., D'Agostino Sr., R.B., Karasik, D., Benjamin, E.J., Guo, C.Y., Govindaraju, Kiel, D.P., Kelly-Hayes, M., Massaro, J.M., Pencina, M.J., Seshadri, S., Murabito,

Genetic correlates of longevity and selected age-related phenotypes: genome-wide association study in the Framingham Study. BMC Med.

(Suppl.

), S

Mockett, R.J., Sohal, R.S., Orr, W.C.,

Overexpression of glutathione reductase tends survival in transgenic Drosophila melanogaster under hyperoxia but not moxia. FASEB J.

,

–

Montesanto, A., Latorre, V., Giordano, M., Martino, C., Domma, F., Passarino, G., The genetic component of human longevity: analysis of the survival advantage parents and siblings of Italian nonagenarians. Eur. J. Hum. Genet.

(