Although GWAS studies have reported significant associations between rs2075650 and Alzheimer's disease, brain imaging, total cholesterol, and CRP plasma levels (Reiner et al., 2008; Aulchenko et al., 2009; Seshadri et al., 2010; Shen et al., 2010), no analyses were performed to determine whether these associations are APOE independent. We observed no APOE-independent effect on the phenotypes investigated in the LLS offspring and partners except for total and LDL cholesterol.

The strength of this study is that, by using a GWIn the first sentence, "controls" should be "centenarians." In the second sentence, "repli- cated" should be "replicated." The third sentence needs a space between "com-" and "pared." In the fourth sentence, "Alzheimers" should have a possessive apostrophe and be "Alzheimer's." In the fifth sentence, "iden- tified" should be "identified." In the sixth sentence, "and 1989" should be removed. In the seventh sentence, "whole-genomeexome" should be split into "whole-genome" and "exome." In the eighth sentence, "merited" should be "warranted." In the ninth sentence, "Lei- den" should be split into "Leiden." In the tenth sentence, "com- prises" should be "comprises." In the eleventh sentence, there is an unnecessary hyphen in "ophthalmo- logical." In the twelfth sentence, there is a missing space between "RS repli-" and "cation cases." Finally, in the last sentence, there is an unnecessary space after the word "using."