title: Amphotericin B lotion in monilial intertrigo: a double-blind paired comparison study. A comparison of the efficacy of oral fluconazole, 150 mg/week versus 50 mg/day, in the treatment of tinea corporis, tinea cruris, tinea pedis, and cutaneous candidosis. [Evaluation of econazol in 594 cases of skin mycosis (author's transl)]. Reduction Mammaplasty Improves Symptoms of Macromastia Problems with clinical trials in general practice--a double-blind comparison of cream containing miconazole and hydrocortisone with hydrocortisone alone in the treatment of intertrigo. Topical treatment of cutaneous candidiasis with 5-fluorocytosine compared with nystatin.
abstract: A double-blind , paired comparison study of 3 % amphotericin lotion and placebo is reported . The placebo was as effective as the active drug ( or vice versa ) . There was no acceptance Two hundred and forty five patients with dermatophytoses and cutaneous c and idosis were enrolled in the study ; 122 were r and omized to the once-weekly regimen and 123 to the once-daily regimen . Subjects included both men and women ; the average age was 42 years . There were no statistically significant differences between the two groups with regard to age , sex , race , and body weight distributions . In the group receiving once-weekly fluconazole , there were 58 tinea pedis infections and 77 nonpedis infections ( tinea corporis , tinea cruris , and cutaneous c and idosis ) . In the group receiving once-daily fluconazole , there were 56 tinea pedis infections and 76 nonpedis infections . The duration of infection and total score of signs and symptoms did not differ significantly between the two groups . Patients received treatment until clinical ly cured or up to a maximum of 6 weeks for tinea pedis and 4 weeks for tinea corporis , tinea cruris , or cutaneous c and idosis . Medical history , physical and laboratory examinations , and the clinical diagnosis were recorded . Clinical and mycologic examinations and laboratory testing were performed at baseline and 2 weeks after treatment initiation , and then weekly until clinical ly cured or the maximum duration of treatment allowed was reached . Safety analysis was performed for all patients . Follow-up clinical and mycologic examinations were performed 1 month after the therapy ended . The clinical efficacy was based on cure ( disappearance of all baseline signs and symptoms of infection ) , marked improvement , moderate improvement , failure ( no change or worsening of the signs and symptoms ) , or unevaluable ( most commonly due to protocol evaluations or the absence of an identified pathogen ) . Mycologic efficacy was based on eradication ( absence of pathogen on microscopy and /or culture ) , persistence ( presence of pathogen on microscopy and /or culture ) , superinfection ( absence of pathogen , but with a different fungal pathogen on microscopy and culture associated with clinical disease ) , or unevaluable . Long-term follow-up evaluation included the category relapse , defined as the absence of pathogen at the end of treatment , with the reappearance of that pathogen on microscopy and /or culture at follow-up visit . The culture result determined the efficacy where discrepancies between microscopy and culture findings occurred A total of 594 patients were treated with the new antimycotic agent econazol ( Pevaryl ) . The diagnosis was proven microscopically and on culture except in cases of pityriasis versicolor where it was proven microscopically only . Econazol was given to 130 patients as a 1 % solution , to 128 patients as a 1 % milk , and to 336 patients as a 1 % spray solution . In 333 cases of foot mycosis or eczema marginatum econazol spray powder was given in addition . As measured by the cure rate the spray solution ( 92 % ) was not significantly more effective than the milk ( 89 % ) or the simple solution ( 87 % ) . Criteria for cure included negative microscopy and fungal cultures a week after treatment had ceased as well as clinical cure . A total of 90 % of all cases ( n = 536 ) could be considered as cured microscopically and on culture after an average of 3.6 weeks ( pityriasis versicolor ) and 4.8 weeks ( tinea pedis , manus , inguinocruralis ) . In a further 4.4 % ( n = 26 ) the fungus could be demonstrated microscopically despite a clinical cure and in 7 of these cases culture was also positive . The cure rate was independent of the responsible pathogen . The preparations were tolerated extremely well . In 7 cases , however , transient dermatitic irritations were seen in the inguinocrural region , mainly caused by the simple solution The condition macromastia has not been defined and characterized precisely by the medical community . Whether the patient with hypertrophic breasts is a c and i date for or can be helped by reduction mammaplasty is unclear to both the medical and the lay community . A prospect i ve study of 39 women undergoing reduction mammaplasty surgery  was initiated to answer these questions . Patients rated the severity of their somatic pain symptoms and discomfort before reduction mammaplasty and again after complete recovery . The severity of their symptoms and complaints was numerically grade d and analyzed . These data were compared with similar data obtained from 40 " small-breasted " women of similar age .  Headache , neck pain , back pain , shoulder pain , and bra strap groove pain were present in 60 to 92 percent of patients , and 97 percent of patients had at least three of these pain symptoms preoperatively . All the patients had reduction of their pain symptomatology postoperative , and 25 percent of the study patients had total elimination of pain symptoms by reduction mammaplasty . The postoperative incidence and severity of pain symptoms and discomfort complaints were statistically equivalent to or less than the levels in the control group A double-blind comparative study between 1 % hydrocortisone cream and a combination of 1 % hydrocortisone cream and 2 % miconazole cream has highlighted some of the problems with this type of research in general practice . The collection of adequate patient numbers within a predefined time scale proved a major problem . However , the study demonstrated the safety and efficacy of both these preparations in the treatment of intertrigo 30 patients with symmetrical intertriginous c and idiasis were treated with 5-fluorocytosine 10 % cream and nystatin gel using the paired comparison method . The agents were applied twice daily for 2
target: Although most study - authors were positive , we could not draw firm conclusions about any of the pharmaceutical interventions .
  Even patients that received placebo intervention showed improvement .
  There is weak evidence that reduction mammaplasty may be helpful to treat inframammary intertrigo .
  Conclusions There is no evidence at all about the prevention of intertrigo and there is no firm evidence about its treatment .
background: Background Intertrigo in the large skin folds is a common problem .
  There is a plethora of treatments , but a lack of evidence about their efficacy .
  A nursing guideline on this matter had to be up date d and broadened in scope to other health care professionals .