title: Principles of Mimicking and Engineering the Self-organized Structure of Hard Tissues*
abstract: The mechanism of the formation of a self-aligned hydroxyapatite ( HAP ) nanocrystallite structure was examined . It is found that the highly ordered HAP nanocrystallite assembly is attributed to the so-called self-(homo)epitaxial nucleation and growth . On the other h and , according to this mechanism , a high supersaturation will give rise to a r and om assembly of HAP crystallites . The effects of ions , biosubstrate , and supersaturation on the micro/nanostructure correlation between substrate and biominerals as well as their implication s in hard tissue formation were examined . Surprisingly , some biomolecules are found to be able to suppress the supersaturation-driven interfacial structure mismatch and hence promote the well aligned HAP pattern formation
target: Experimental  methacrylate-based adhesives , either when incorporating calcium/sodium phosphate-phyllosilicates or calcium silicate cements , demonstrated to promote therapeutic/protective effects on the micro-mechanical and ultramorphological properties of resin bonded-dentine interfaces associated with mineral deposition over time .
background: The origin of ion-releasing dentine bonding agents lies in a change in attitude regarding the qualities dem and ed of a restorative dental material .