title: Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss. Alpha-lipoic acid reduces body weight and regulates triglycerides in obese patients with diabetes mellitus. A Preliminary Investigation of &agr;-Lipoic Acid Treatment of Antipsychotic Drug-Induced Weight Gain in Patients With Schizophrenia α-Lipoic acid reduced weight gain and improved the lipid profile in rats fed with high fat diet Effects of alpha-lipoic Acid on body weight in obese subjects. The Protective Effects of α-Lipoic Acid on Kidneys in Type 2 Diabetic Goto-Kakisaki Rats via Reducing Oxidative Stress Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial. Quercetin and Vitamin C Supplementation: Effects on Lipid Profile and Muscle Damage in Male Athletes The Delphi list: a criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus. Effects of Cinnamon, Cardamom, Saffron, and Ginger Consumption on Markers of Glycemic Control, Lipid Profile, Oxidative Stress, and Inflammation in Type 2 Diabetes Patients. Effect of (R)-α-Lipoic Acid Supplementation on Serum Lipids and Antioxidative Ability in Patients with Age-Related Macular Degeneration Effects of α-Lipoic Acid on the Plasma Levels of Asymmetric Dimethylarginine in Diabetic End-Stage Renal Disease Patients on Hemodialysis: A Pilot Study Effects of alpha-lipoic acid supplementation on inflammation, oxidative stress, and serum lipid profile levels in patients with end-stage renal disease on hemodialysis. Lipoic acid prevents high-fat diet-induced dyslipidemia and oxidative stress: a microarray analysis. Effect of Probiotic Soy Milk on Serum Levels of Adiponectin, Inflammatory Mediators, Lipid Profile, and Fasting Blood Glucose Among Patients with Type II Diabetes Mellitus Comparison of the effect of alpha-lipoic acid and alpha-tocopherol supplementation on measures of oxidative stress. Impact of therapy with alpha-lipoic acid (ALA) on the oxidative stress in the controlled NIDDM: a possible preventive way against the organ dysfunction?
abstract: OBJECTIVE To evaluate the potential body weight-lowering effects of dietary supplementation with eicosapentaenoic acid ( EPA ) and α-lipoic acid separately or combined in healthy overweight/obese women following a hypocaloric diet . METHODS This is a short-term double-blind placebo-controlled study with parallel design that lasted 10 weeks . Of the r and omized participants , 97 women received the allocated treatment  [ Control , EPA ( 1.3 g/d ) , α-lipoic acid ( 0.3 g/d ) , and EPA+α-lipoic acid ( 1.3 g/d+0.3 g/d ) ] , and 77 volunteers completed the study . All groups followed an energy-restricted diet of 30 % less than total energy expenditure . Body weight , anthropometric measurements , body composition , resting energy expenditure , blood pressure , serum glucose , and insulin and lipid profile , as well as leptin and ghrelin levels , were assessed at baseline and after nutritional intervention . RESULTS Body weight loss was significantly higher ( P<0.05 ) in those groups supplemented with α-lipoic acid . EPA supplementation significantly attenuated ( P<0.001 ) the decrease in leptin levels that occurs during weight loss . Body weight loss improved lipid and glucose metabolism parameters but without significant differences between groups . CONCLUSIONS The intervention suggests that α-lipoic acid supplementation alone or in combination with EPA may help to promote body weight loss in healthy overweight/obese women following energy-restricted diets AIM To determine an influence of alpha-lipoic acid to reduction of body weight and regulation of total cholesterol concentration , triglycerides and glucose serum levels in obese patients with diabetes mellitus type 2 . METHODS A prospect i ve study includes two groups of obese patients with diabetes mellitus and signs of peripheral polyneuropathia : examined group ( 30 patients ; 15 females and 15 males ) , and control group ( 30 patients ; 12 females and 18 males ) . All were treated with metformin ( 850 - 1700 mg/day ) . Examined patients were additionally treated with alpha-lipoic acid 600 mg/day during 20 weeks . Body mass index and concentrations of total cholesterol , triglycerides and glucose in serum were compared before and after the treatment . RESULTS The group treated with 600 mg alpha-lipoic acid lost significantly more weight , and had lower triglyceride level than the control group . There were no significant differences in total cholesterol and glucose serum levels between the groups . CONCLUSION Alpha-lipoic acid of 600 mg/day treatment have influenced weight and triglycerides loss in obese patients with diabetes mellitus type 2 . It should be considered as an important additive therapy in obese patients with diabetes mellitus type 2 Weight gain and other metabolic disturbances have now become discouraging , major side effects of atypical antipsychotic drugs ( AAPDs ) . The novel strategies required to counteract these serious consequences , however , should avoid modulating the activities of the neurotransmitter receptors involved because those receptors are the therapeutic targets of AAPDs . Adenosine monophosphate-activated protein kinase is an enzyme that plays a pivotal role in energy homeostasis . We hypothesized that & agr;-lipoic acid ( ALA ) , which is known to modulate adenosine monophosphate-activated protein kinase activity in the hypothalamus and peripheral tissues , would ameliorate AAPD-induced  weight gain . We describe the case series of a 12-week ALA trial in schizophrenia patients treated with AAPDs . Two of 7 enrolled subjects were dropped from the study because of noncompliance and dem and for new medication to treat depressive symptoms , respectively . The mean ( SD ) weight loss was 3.16 ( 3.20 ) kg ( P = 0.043 , last observation carried forward ; median , 3.03 kg ; range , 0 - 8.85 kg ) . On average , body mass index showed a significant reduction ( P = 0.028 ) over the 12 weeks . During the same period , a statistically significant reduction was also observed in total cholesterol levels ( P = 0.042 ) , and there was a weak trend toward the reduction in insulin resistance ( homeostasis model assessment of insulin resistance ) ( P = 0.080 ) . Three subjects reported increased energy subjectively . The total scores on the Brief Psychiatric Rating Scale and the Montgomery-Asberg Depression Rating Scale did not vary significantly during the study . These preliminary data suggest the possibility that ALA can ameliorate the adverse metabolic effects induced by AAPDs . To confirm the benefits of ALA , more extended study is warranted The purpose of this study was to investigate the effects of α-lipoic acid on body weight and lipid profiles in Sprague-Dawley rats fed a high fat diet ( HFD ) .  After 4 weeks of feeding , rats on the HFD were divided into three groups by r and omized block design ; the first group received the high-fat-diet ( n = 10 ) , and the second group received the HFD administered with 0.25 % α-lipoic acid ( 0.25LA ) , and the third group received the high-fat diet with 0.5 % α-lipoic acid ( 0.5LA ) . The high fat diet with α-lipoic acid supplemented groups had significantly inhibited body weight gain , compared to that in the HFD group ( P < 0.05 ) . Organ weights of rats were also significantly reduced in liver , kidney , spleen , and visible fat tissues in rats supplemented with α-lipoic acid ( P < 0.05 ) . Significant differences in plasma lipid profiles , such as total lipids , total cholesterol , triglycerides , low-density lipoprotein , and high-density lipoprotein , were observed between the HFD and 0.5LA groups . The atherogenic index and the plasma high density lipoprotein-cholesterol/total cholesterol ratio improved significantly with α-lipoic acid supplementation in a dose-dependent manner ( P < 0.05 ) . Total hepatic cholesterol and total lipid concentration decreased significantly in high fat fed rats supplemented with α-lipoic acid in a dose-dependent manner ( P < 0.05 ) , whereas liver triglyceride content was not affected . In conclusion , α-lipoic acid supplementation had a positive effect on weight gain and plasma and liver lipid profiles in rats PURPOSE alpha-lipoic acid is an essential cofactor for mitochondrial respiratory enzymes that improves mitochondrial function . We previously reported that alpha-lipoic acid markedly reduced body weight gain in rodents . The purpose of this study was to determine whether alpha-lipoic acid reduces body weight in obese human subjects . METHODS in this r and omized , double-blind , placebo-controlled , 20-week trial , 360 obese individuals ( body mass index [ BMI ] ≥ 30 kg/m(2 ) or BMI 27 - 30 kg/m(2 ) plus hypertension , diabetes mellitus , or hypercholesterolemia ) were r and omized  to alpha-lipoic acid 1200 or 1800 mg/d or placebo . The primary end point was body weight change from baseline to end point . RESULTS the 1800 mg alpha-lipoic acid group lost significantly more weight than the placebo group ( 2.1 % ; 95 % confidence interval , 1.4 - 2.8 ; P<.05 ) . Urticaria and itching sensation were the most common adverse events in the alpha-lipoic acid groups , but these were generally mild and transient . CONCLUSION alpha-lipoic acid 1800 mg/d led to a modest weight loss in obese subjects . Alpha-lipoic acid may be considered as adjunctive therapy for obesity To evaluate the protective effects of α-lipoic acid on the kidneys of Goto-Kakisaki ( GK ) diabetic rats , ten GK diabetic rats were r and omly divided into a diabetic control group and a lipoic acid-treated diabetic group with α-lipoic acid 35 mg·Kg−1 intraperitoneal injections . Four healthy Wistar rats served as normal controls . Malonaldehyde ( MDA ) , ascorbic acid ( vitamin C ) , vitamin E , glutathione ( GSH ) and superoxide dismutase ( SOD ) levels in renal homogenate , and urine protein excretion were measured . The expression of mRNA for NF-κB , NADPH oxidase subunits p22phox and p47phox in renal tissue was examined by realtime PCR . Pathological changes in renal tissue were evaluated by light and electron microscopy . There were significant increases in urine protein excretion , MDA levels and the expression of mRNA of NF-κB , p22phox and p47phox , and significant decreases in GSH , SOD , vitamin C and vitamin E levels in the diabetic control group compared with the normal control group . Pathological changes of renal tissue were more progressive in the diabetic control group than in the normal control group . All the parameters above were improved in the α-lipoic acid-treated diabetic group . Oxidative stress is increased in the kidney of type 2 diabetic GK rats . It is associated with the progression of diabetic nephropathy . α-lipoic acid can protect renal function in diabetic rats via its antioxidant activity OBJECTIVE The aim of this study was to investigate the effect of alpha-lipoic acid ( ALA ) treatment on endothelium-dependent and -independent vasodilatation , assessed by forearm blood flow ( FBF ) , in patients with type 2 diabetes mellitus . RESEARCH DESIGN AND METHODS A total of 30 subjects with type 2 diabetes were included in this r and omized , controlled , double-blinded , parallel group study . FBF responses to intra-arterial acetylcholine ( ACh ) and glycerol trinitrate ( GTN ) were measured before and after 21 days of intravenous treatment with 600 mg alpha-lipoic acid or placebo . RESULTS FBF responses were comparable at baseline . After treatment , FBF reactivity to ACh and GTN was unchanged in subjects receiving placebo . By contrast , ALA treatment increased endothelium-dependent vasodilatation to ACh ( P < 0.05 ) but not to GTN compared with baseline . CONCLUSIONS Intravenous ALA treatment improves endothelium-dependent vasodilatation in patients with type 2 diabetes , in the absence of effects on forearm vasomotor function . If this salutary action translates into vascular risk reduction remains to be established Background : Quercetin , which is considered as a health-promoting antioxidant , belongs to the broad flavonoids group . Numerous experimental studies have proved that quercetin and vitamin C provide anti-inflammatory and antioxidant properties . The aim of this study is to assess the effects of both quercetin and vitamin C on lipid profile and muscle damage in human subjects . Methods : A r and omized , placebo-controlled , double-blind clinical trial was carried out on 60 males for eight weeks . The subjects were r and omly assigned to one of the four groups : 1 ) quercetin + vitamin C ( 500 mg/day quercetin + 200 mg/day vitamin C ) 2 ) quercetin ( 500 mg/day quercetin + 200 mg/day placebo ) 3 ) vitamin C ( 500 mg/day vitamin C + 200 mg/day placebo ) and 4 ) placebo ( 500 mg/day placebo + 200 mg/day placebo ) . Blood sample s , body weight and percent of body fat were measured before and after intervention . In addition , dietary intake was estimated using 24-h recall . Results : No significant changes occurred in high-density lipoprotein levels between groups and in the four groups before and after supplementation . Low density lipoprotein values decreased significantly ( P = 0.048 ) in the “ Quercetin + Vit C ” group but decrease was not considerable in other groups before and after intervention and among groups . Fat-soluble vitamins ' intake was significantly high among 4 groups . Conclusions : Quercetin and vitamin C supplementation may not be beneficial in lipid profile improvement , although it may reduce induce muscle damage and body fat percent Most systematic review s rely substantially on the assessment of the method ological quality of the individual trials . The aim of this study was to obtain consensus among experts about a set of generic core items for quality assessment of r and omized clinical trials ( RCTs ) . The invited participants were experts in the field of quality assessment of RCTs . The initial item pool contained all items from existing criteria lists . Subsequently , we reduced the number of items by using the Delphi consensus technique . Each Delphi round comprised a question naire , an analysis , and a feedback report . The feedback report included staff team decisions made on the basis of the analysis and their justification . A total of 33 international experts agreed to participate , of whom 21 completed all question naires . The initial item pool of 206 items was reduced to 9 items in three Delphi rounds . The final criteria list ( the Delphi list ) was satisfactory to all participants . It is a starting point on the way to a minimum reference st and ard for RCTs on many different research topics . This list is not intended to replace , but rather to be used alongside , existing criteria lists OBJECTIVES Type 2 diabetes ( T2D ) may be caused by elevated oxidative stress , inflammation , and hyperglycemia . The phytochemicals in several herbal medicines are reported to effectively improve diabetes and to ameliorate diabetic complications . The aim of the present study was to determine the effects of cinnamon , cardamom , saffron , and ginger as supplementary remedies in T2D . METHODS This r and omized controlled , clinical trial included 204 T2D patients . The participants were r and omly assigned to four intervention groups receiving 3 glasses of black tea and either 3 g cardamom , or cinnamon , or ginger , or 1 g saffron and one control group which consumed only 3 tea glasses without any herbal medicine for 8 weeks . Markers of inflammation , oxidative stress , fasting blood sugar , lipid profile , and anthropometric measures were evaluated at baseline and after 8 weeks of intervention . RESULTS After 8 weeks of intervention , cinnamon , cardamom , ginger , and saffron consumption had significant effects on total cholesterol , LDL , and HDL levels ( p < 0.05 ) compared with controls . However , the herbal products did not have significant effects on measures of glycemic control , anthropometry , inflammation , and oxidative stress . In within-group comparisons only , cinnamon intake significantly decreased fasting blood sugar ( FBS ) . CONCLUSIONS The herbal remedies examined had significantly beneficial effects on cholesterol , but not on measures of glycemic control , oxidative stress , and inflammation . Based on the contradictory results reported in the literature , the effects of herbal medicine in diabetic patients should undergo further detailed investigation Background / Aims : Supplementation with antioxidants is of special interest in preventing or delaying the development and progression of age-related macular degeneration ( AMD ) . This investigation aim ed to assess the effect of α- lipoic acid ( LA ) on serum lipids , serum malondialdehyde ( MDA ) and superoxide dismutase ( SOD ) in patients with AMD . Methods : A total of 62 patients ( 50–75 years old ) with early and intermediate dry form of AMD were r and omly assigned to two groups , i.e. LA administration ( n = 32 ) and placebo ( n = 30 ) . The levels of serum lipids and MDA and SOD activity were measured before and after LA and placebo intervention . Results : Compared with the parameters at baseline , serum total cholesterol ( CHO ) , triglyceride and high- and low-density lipoprotein CHO ( HDL and LDL ) levels were not significantly different after LA and placebo intervention . There was a slight but statistically nonsignificant decrease in serum MDA levels and a statistically significant increase in serum SOD activity after LA intervention . There were no statistically significant differences in serum MDA levels or SOD activity after placebo intervention . Conclusion : The apparent increase in SOD activity caused by LA supplementation indicates that LA may have a possible preventive effect in the development of AMD through an antioxidant mechanism Background / Aim : Endothelial dysfunction due to reduced nitric oxide ( NO ) availability precedes the development of atherosclerosis . Asymmetric dimethylarginine ( ADMA ) , an endogenous inhibitor of NO synthase , is not only a cause of endothelial dysfunction , but also a predictor of the cardiovascular outcome in end-stage renal disease ( ESRD ) patients on hemodialysis ( HD ) .  α-Lipoic acid ( ALA ) , a strong antioxidant , increases NO-mediated vasodilation in diabetic patients . We investigated whether ALA could decrease the plasma level of ADMA in diabetic ESRD patients on HD . Methods : Fifty patients undergoing HD three times per week were r and omized to a treatment group receiving ALA 600 mg/day for 12 weeks or a control group . We measured the plasma levels of cholesterol , albumin , high-sensitivity C-reactive protein , oxidized low-density lipoprotein , hemoglobin A1c , and ADMA in both groups at baseline and at 12 weeks . Results : In the control group , the levels of total cholesterol , serum albumin , high-sensitivity C-reactive protein , oxidized low-density lipoprotein , hemoglobin A1c , and ADMA did not change . In the treatment group , the plasma levels of ADMA decreased significantly from a median of 1.68 ( range 0.45–3.78 ) µM to a median of 1.31 ( range 0.25–3.19 ) µM ( p = 0.001 ) . Conclusion : Considering that ADMA is an independent risk factor for cardiovascular outcome in ESRD patients  , ALA may have the potential of a beneficial effect in them , in part by decreasing the plasma level of ADMA OBJECTIVE We examined the effects of alpha-lipoic acid ( ALA ) supplementation on inflammation , oxidative stress , and serum lipid profile levels in hemodialysis ( HD ) patients . DESIGN This was a double-blinded , r and omized , placebo-controlled clinical trial . SETTING The present study involved HD centers in Tabriz , Iran . PATIENTS Participants included 63 patients with end-stage renal disease ( 43 men and 20 women ; age range : 22 - 79 years ) undergoing maintenance HD . INTERVENTION HD patients were r and omly assigned into the supplemented group ( n = 31 ) , receiving a daily dose of ALA ( 600 mg ) , or a control group ( n = 32 ) , receiving placebo for 8 weeks . MAIN OUTCOME MEASURES High sensitivity C-reactive protein ( hsCRP ) , malondialdehyde , total antioxidant status , total cholesterol , triglyceride , high-density lipoprotein cholesterol ( HDL-C ) , and low-density lipoprotein cholesterol ( LDL-C ) were measured at baseline and after 8 weeks of supplementation . RESULTS At the end of intervention , 11 patients were excluded from the study .  HsCRP levels decreased by 18.7 % in the supplemented group after 8 weeks of supplementation , and the reduction was significant in comparison with the placebo group ( P < .05 ) ; this finding was also significant after adjusting for baseline values of hsCRP . The mean malondialdehyde and total antioxidant status levels did not change significantly in the 2 groups during the study . The mean high-density lipoprotein cholesterol concentrations increased significantly in the supplemented group at the end of the study ( P < .05 ) ; however , this improvement was not statistically significant as compared with the placebo group . No significant alterations were observed in the other lipid profile parameters within each group during the study . CONCLUSION ALA supplementation significantly reduced hsCRP levels , which is a risk factor for cardiovascular disease in HD patients OBJECTIVE We previously found that lipoic acid ( LA ) improved high-fat diet (HFD)-induced dyslipidemia in rats . To eluci date the molecular mechanisms of that effect , we carried out experiments aim ed at analyzing biochemical parameters and gene expression profiles . METHODS C57BL/6 mice were r and omly assigned to one of three groups ( n = 8) . The control group consumed an ordinary diet ( 4.89 % fat , w/w ) . The other two experimental groups were fed with an HFD ( 21.45 % fat , w/w ) or an HFD plus 0.1 % LA . After 6 wk , plasma lipid level and antioxidant status were examined . To investigate the molecular mechanisms underlying the effects of LA on lipid metabolism and oxidative stress , we examined gene expression profiles in liver using the GeneChip microarray system . The differential expression of genes of interest identified by microarray technique was vali date d by real-time reverse transcription-polymerase chain reaction . RESULTS HFD result ed in significant alterations in lipid profiles and a depressed antioxidant defense system .  LA supplementation induced decreases in lipid peroxidation , plasma cholesterol , triacylglycerols , and low-density lipoprotein cholesterol and an increase in high-density lipoprotein in HFD-fed mice . DNA microarray analysis of the liver showed that LA ingestion upregulated the expression of genes related to beta-oxidation and free radical scavenger enzymes , whereas those involved in cholesterol synthesis were downregulated . CONCLUSION LA can prevent HFD-induced dyslipidemia by modulating lipid metabolism , especially by increasing beta-oxidation and decreasing cholesterol synthesis , and oxidative stress by increasing those of free radical scavenger enzyme gene expression Probiotic therapies are going to be an effective alternative therapeutic strategy in the treatment and management of diabetes . The mechanism behind the essential effects of probiotic therapies in diabetic patients was not fully understood . The objective of this study was to evaluate the effects of probiotic soy milk containing Lactobacillus planetarum A7 on inflammation , lipid profile , fasting blood glucose , and serum adiponectin among patients with type 2 diabetes mellitus . Forty patients with type 2 diabetes , at the age of 35–68 years old , were assigned to two groups in this r and omized , double-blind , controlled clinical trial . The patients in the intervention group consumed 200 ml/day of probiotic soy milk containing L. planetarum A7 and those in control group consumed 200 ml/day of pure soy milk for 8 weeks  . Serum TNF-α , C reactive protein , adiponectin , lipid profile , and fasting blood glucose were determined before and after intervention . In intervention group , serum adiponectin in pre- and post-treatment did not show any significant changes ( 2.52 ± 0.74 vs 2.84 ± 0.61 , P = 0.658 ) , as well as changes in serum TNF-α and C reactive protein ( 172.44 ± 5.7 vs 172.83 ± 7.6 , P = 0.278 , 4.2 ± 1.4 vs 4.5 ± 1.9 , P = 0.765 , respectively ) . Low-density cholesterol and high-density cholesterol changed significantly ( P = 0.023 , P = 0.017 , respectively ) , but fasting blood glucose did not show any significant changes . The results of this study showed that consumption of probiotic soy milk and soy milk has no effect on serum adiponectin and inflammation , but it can change lipid profile among type 2 diabetic patients In vitro studies have shown that alpha-lipoic acid ( LA ) is an antioxidant . There is a paucity of studies on LA supplementation in humans . Therefore , the aim of this study was to assess the effect of oral supplementation with LA alone and in combination with alpha-tocopherol ( AT ) on measures of oxidative stress . A total of 31 healthy adults were supplemented for 2 months either with LA ( 600 mg/d , n = 16 ) , or with AT ( 400 IU/d , n = 15 ) alone , and then with the combination of both for 2 additional months . At baseline , after 2 and 4 months of supplementation , urine for F2-isoprostanes , plasma for protein carbonyl measurement and low-density lipoprotein ( LDL ) oxidative susceptibility was collected . Plasma oxidizability was assessed after incubation with 100 mM 2,2'-azobis ( 2-amidinopropane ) hydrochloride ( AAPH ) for 4 h at 37 degrees C. LDL was subjected to copper- and AAPH-catalyzed oxidation at 37 degrees C over 5 h and the lag time was computed . LA significantly increased the lag time of LDL lipid peroxide formation for both copper-catalyzed and AAPH-induced LDL oxidalion ( p < .05 ) , decreased urinary F2-isoprostanes levels ( p < .05 ) , and plasma carbonyl levels after AAPH oxidation ( p < .001 ) . AT prolonged LDL lag time of lipid peroxide formation ( p < .01 ) and conjugated dienes ( p < .01 ) after copper-catalyzed LDL oxidation , decreased urinary F2-isoprostanes ( p < .001 ) , but had no effect on plasma carbonyls . The addition of LA to AT did not produce an additional significant improvement in the measures of oxidative stress . In conclusion , LA supplementation functions as an antioxidant , because it decreases plasma- and LDL-oxidation and urinary isoprostanes There is a growing evidence that excess generation of highly reactive free radicals , largely due to hyperglycemia , causes oxidative stress , which further exacerbates the development and progression of diabetes and its complications . The purpose of this study was to evaluate the impact of ALA on lipid profile , oxidative pattern and inflammation in patients with controlled non-insulin dependent diabetes mellitus ( NIDDM ) .  ALA , 400mg/day was investigated in NIDDM patients over a period of 4 weeks using a r and omized , placebo-(PLA)-controlled study with two parallel groups . The marker of oxidative stress was the concentration of reactive oxygen metabolites , evaluated using a commercially available test , called d-ROMs  test  , and the  biological antioxidant potential ( BAP ) ; besides , the lipid profile ( total cholesterol = TC , high-density lipoprotein-cholesterol = HDL-C ; low-density lipoprotein-cholesterol = LDL-C , and triglycerides = TG ) and the C-reactive protein ( CRP ) , marker of inflammation were measured at the beginning and at the end of the treatment . A total of 14 patients were r and omly assigned to the two groups . ALA was safe and well tolerated in the only oral daily administration . The d-ROMs test ( p=0.03 ) and HDL-C ( p=0.04 ) showed a significant difference between the two groups . BAP ( p=0.06 ) tended to be higher in the treated patients , while LDL-C ( p=0.07 ) presented a moderate decline . There were no significant differences in TC ( p=0.65 ) , TG ( p=0.78 ) and CRP ( p=0.96 ) between the ALA and PLA groups . ALA therapy appears to reduce significantly d-ROMs and to improve HDL-C value , especially in men with metabolic syndrome treated with oral hypoglycemic drugs . These findings will be useful in patient selection in future clinical trials with ALA in long term studies
target: The overall  effect of ALA on serum triglyceride did not reveal any significant change , but in subgroup analysis based on health status ( diabetic vs. non‐diabetic ) , ALA decreased serum triglyceride levels in both diabetic and non‐diabetic groups compared with controls .
  This meta‐ analysis revealed that ALA might favorably affect lipid profile especially LDL and TC .
background: ABSTRACT R and omized controlled trials ( RCTs ) have demonstrated that alpha lipoic acid ( ALA ) may change lipid profile , but their results are contradictory .
  The aim of this study is to conduct a meta‐ analysis to assess the effects of ALA on lipid profile .