title: Clinical and radiographic comparison of biodentine, mineral trioxide aggregate and formocresol as pulpotomy agents in primary molars Sealing ability of ProRoot MTA and MTA-Angelus simulating a one-step apical barrier technique--an in vitro study. Clinical and radiographical evaluation of mineral trioxide aggregate, biodentine and propolis as pulpotomy medicaments in primary teeth Comparative Evaluation of Clinical and Radiographic Success of Formocresol, Propolis, Turmeric Gel, and Calcium Hydroxide on Pulpotomized Primary Molars: A Preliminary Study Light-cured calcium hydroxide vs formocresol in human primary molar pulpotomies: a randomized controlled trial. Short-term treatment outcome of pulpotomies in primary molars using mineral trioxide aggregate and Biodentine: a randomized clinical trial Comparison between biodentine and formocresol for pulpotomy of primary teeth: A randomized clinical trial. Response of human dental pulp capped with biodentine and mineral trioxide aggregate. The Clinical and Radiographic Success of Primary Molar Pulpotomy Using Biodentine™ and Mineral Trioxide Aggregate: A 24-Month Randomized Clinical Trial. Clinical Evaluation of Success of Primary Teeth Pulpotomy Using Mineral Trioxide Aggregate(®), Laser and Biodentine(TM)- an In Vivo Study. Mineral Trioxide Aggregate vs. Calcium Hydroxide in Primary Molar Pulpotomy: A Systematic Review Mineral trioxide aggregate versus calcium hydroxide for pulpotomy in primary molars.
abstract: Aim To compare the clinical and radiographic success rates of three different pulpotomy agents in primary molars after 18 months . Methods The study was carried out with 51 primary molars of children aged 5–9 years old . The teeth were r and omly assigned to the experimental or control groups . After coronal pulp removal and haemostasis , the remaining pulp tissue was covered with Biodentine ® or mineral trioxide aggregate in the experimental groups . In the control group , formocresol was placed with a cotton pellet over the pulp tissue for 5 min and after removal the pulp tissue was covered with zinc oxide – eugenol ( ZOE ) paste . All teeth were immediately restored with reinforced ZOE base and resin modified glass-ionomer cement , and later with pre-formed metal crowns . Follow-up assessment s were carried out after 3 , 6 , 12 and 18 months . Results Forty-five teeth were available for follow up at the end of 18 months . All of the available teeth for mineral trioxide aggregate and Biodentine ® were clinical ly successful , as were 73.3 % of the FC group . Radiographic success rate for the formocresol group at 18 months follow up was 73.3 , 100 % for mineral trioxide aggregate and 86.6 % for Biodentine ® group . Conclusion Mineral Trioxide aggregate and Biodentine ® showed more favourable results than formocresol Endodontic treatment of the pulpless tooth with an immature root apex poses a special challenge for the clinician due to lack of an apical stop against which to compact an interim dressing of calcium hydroxide , or the final obturation material . A one-visit apexification protocol with MTA ( Mineral Trioxide Aggregate ) has be seen as an alternative to the traditional treatment practice s with calcium hydroxide [ Ca(OH)2 ] . The aim of this study was to investigate the use of MTA as a 5 mm apical barrier by comparing sealing ability of ProRoot MTA to that of MTA-Angelus . 50 freshly extracted Maxillary and M and ibular single canal sound human incisor teeth were used in this study , which were decoronated to st and ardized 10 mm root lengths . The root segments were prepared to simulate the clinical situation of an open apex with Gates Glidden burs # 51 and r and omly assigned into 2 experimental groups of 20 sample s each ( Group A : ProRoot MTA , Group B : MTA-Angelus ) and 10 root segments were used as control ( Group C ) where no apical barrier was used . After obturation the coronal portion of all sample s were sealed with Glass Ionomer and stored at 37 degrees C and 100 % humidity for 4 weeks . The root segments were then double coated with nail varnish except for the apical 1 mm and apical ends of all root segments were suspended vertically in methylene blue dye for 48 hours at room temperature . After removal from the dye , the sample s were sectioned longitudinally and linear dye penetration was measured using a Grid and stereomicroscope . The measurements were tabulated and statistically analyzed . The mean percentage of dye leakage for Group A was 55.5 % and for Group B was 53.25 % . The results showed no statistically significant difference in the sealing ability of ProRoot MTA and MTA-Angelus when used as apical barriers Objectives The purpose of this study was to evaluate the efficacy of mineral trioxide aggregate ( MTA ) , Biodentine and Propolis as pulpotomy medicaments in primary dentition , both clinical ly and radiographically . Material s and Methods A total of 75 healthy 3 to 10 yr old children each having at least one carious primary molar tooth were selected . R and om assignment of the pulpotomy medicaments was done as follows : Group I , MTA ; Group II , Biodentine ; Group III , Propolis . All the pulpotomized teeth were evaluated at 3 , 6 , and 9 mon clinical ly and radiographically , based on the scoring criteria system . Results The clinical success rates were found to be similar among the three groups at 3 and 6 mon where as a significant decrease in success rate was observed in Group III ( 84 % ) compared to both Group I ( 100 % ) and Group II ( 100 % ) at 9 mon . Radiographic success rates over a period of 9 mon in Groups I , II , and III were 92 , 80 , and 72 % , respectively . Conclusions Teeth treated with MTA and Biodentine showed more favorable clinical and radiographic success as compared to Propolis at 9 mon follow-up Aims Despite various advents in technology , the present era marks a shift to phytotherapeutics and alternative modalities to conventional endodontic treatments . Newer endodontic modalities have been developed inculcating the ancient system of medicine . The present study was done to compare and evaluate the clinical pulp response and radiographic signs after pulpotomy in four groups of primary molar teeth treated with formocresol ( control ) , propolis extract , turmeric gel , and calcium hydroxide respectively . Material s and methods Following ethical clearance , 90 primary molar teeth in 45 pediatric patients , aged between 4 and 9 years , were selected for pulpotomy . These were then r and omly divided by split-mouth technique into two groups as experimental ( propolis extract/turmeric gel/calcium hydroxide ) and control ( formocresol ) groups . The patients were followed up for 6 months for clinical and radiographic signs and symptoms to evaluate the success of treatment . Results A comparable clinical and radiographic success rate was seen with all experimental groups as compared to the control ( formocresol ) group . Conclusion With concerns about the safety of formocresol appearing in the dental and medical literature for more than 20 years , the material s used in this study can be considered as promising alternatives for formocresol in pediatric endodontic treatment . How to cite this article Hugar SM , Kukreja P , Hugar SS , Gokhale N , Assudani H. Comparative Evaluation of Clinical and Radiographic Success of Formocresol , Propolis , Turmeric Gel , and Calcium Hydroxide on Pulpotomized Primary Molars : A Preliminary Study . Int J Clin Pediatr Dent 2017;10(1):18 - 23 PURPOSE The purpose of this prospect i ve study was to compare light-cured calcium hydroxide ( Ca(OH)2 ) with diluted formocresol ( FC ) for its success as a primary molar pulpotomy medicament METHODS Selection criteria included at least 2 matching , asymptomatic , contralateral primary molars requiring vital pulpotomies . Matched teeth in each patient were r and omized to receive either Ca(OH)2 or FC as a pulpotomy medicament . All teeth were restored with prefabricated metal crowns .  Twenty patients ( 34 pairs of teeth ) were followed clinical ly and radiographically for > or = 1 year . Two blinded , st and ardized , and calibrated examiners evaluated and scored each radiograph for signs of pathology , based upon a modified scale previously proposed . RESULTS Findings were grouped in : ( a ) 0 - 6 ; ( b ) 7 - 12 ; and ( c ) 13 - 24 month intervals . Radiographic scoring favored the FC group of the 7- to 12- and 13- to 24-month intervals ( P<.05 ) . Clinical success was similar for Ca(OH)2 ( 94 % ) and FC ( 97 % ) at 12 months or less . Beyond 12 months , clinical success varied more ( Ca(OH)2=84 % , FC=97 % ) , but not significantly ( P=.08 ) . Combined success rates were lower for Ca(OH)2 ( 56 % ) than FC ( 94 % ) . CONCLUSIONS Light-cured calcium hydroxide does not appear to be a viable alternative to diluted formocresol as a pulpotomy agent Introduction An ideal pulpotomy agent for primary molars has been sought for many years . Recently , new material s that allow regeneration of residual pulp tissue have been developed . In this study , we compared the preliminary clinical results obtained using Biodentine and mineral trioxide aggregate ( MTA ) as pulp-dressing agents in pulpotomies of primary molars . Methods A r and omized clinical study was performed in children aged 4–9 years with at least one primary tooth with decay or caries requiring pulp treatment . A total of 90 primary molars requiring pulpotomy were r and omly allocated to the MTA or Biodentine group , and 84 pulpotomies were performed . Clinical and radiographic evaluations were undertaken 6 and 12 months after treatment . All teeth were restored with a reinforced zinc oxide – eugenol base and stainless steel crowns . Statistical analysis using Fisher ’s exact test was performed to determine the significant differences between the groups . Results A total of four clinical failures were observed ; all involved gingival inflammation . The clinical success rate in the MTA Group after 12 months was 92 % ( 36/39 ) , whereas the Biodentine Group obtained 97 % ( 38/39 ) ( p = 0.346 ) . All radiographic failures were observed at the 12-month follow-up evaluation . One molar from MTA Group showed internal resorption obtaining a radiographic success rate of 97 % ( 38/39 ) . Two molars from the Biodentine Group showed radiographic failure ( 1 internal resorption and 1 periradicular radiolucency ) obtaining a radiographic success rate of 95 % ( 37/39 ) . Conclusions Biodentine showed similar clinical results as MTA with comparable success rates when used for pulpotomies of primary molars . However , longer follow-up studies are required to confirm our findings . Clinical relevance This article demonstrates the effectiveness of Biodentine as a primary teeth pulpotomy material , performing similar results as MTA at 12-months evaluation OBJECTIVE To assess and compare the clinical and radiographic success rates of biodentine and formocresol for pulpotomy in human primary teeth . METHOD AND MATERIAL S A r and omized , split-mouth , double-blind , controlled clinical trial was carried out in 37 healthy 4- to 8-year-old children with 56 pairs ( 112 teeth ) of contralateral primary molars indicated for pulpotomy . Matched teeth in each pair were r and omized to undergo either biodentine ( n = 56 teeth ) or formocresol ( n = 56 teeth ) pulpotomy . In both groups , the teeth were restored with stainless steel crowns . The teeth were evaluated clinical ly and radiographically at 3 and 6 months by two blinded , st and ardized , and calibrated examiners . The data were analyzed using chi-square and McNemar tests with a P value of < .05 considered significant . RESULTS At both the 3- and 6-month follow-ups , all the 37 children with 112 treated teeth were evaluated . Clinical and radiographic success was similar for biodentine ( 100 % ) and formocresol ( 100 % ) , without any statistically significant difference ( P = 1 ) . Pulp canal obliteration was radiographically observed in 10/56 ( 17.9 % ) and 7/56 ( 12.5 % ) cases in the biodentine and formocresol groups , respectively . CONCLUSION Both pulpotomy techniques showed favorable clinical and radiographic outcomes at 3 and 6 months posttreatment without any significant difference . Hence , biodentine has the potential to become a substitute for formocresol in primary molar pulpotomies INTRODUCTION Biodentine is a new bioactive cement that is similar to the widely used mineral trioxide aggregate ( MTA ) . It has dentin-like mechanical properties , which may be considered a suitable material for clinical indications of dentin-pulp complex regeneration such as direct pulp capping . The purpose of the present study was to compare the response of the pulp-dentin complex in human teeth after direct capping with this new tricalcium silicate-based cement with that of MTA . METHODS Pulps in 28 caries-free maxillary and m and ibular permanent intact human molars scheduled for extraction for orthodontic reasons were mechanically exposed and assigned to 1 of 2 experimental groups , Biodentine or MTA , and 1 control group . Assay of periapical response and clinical examination were performed . After 6 weeks , the teeth were extracted , stained with hematoxylin-eosin , and categorized by using a histologic scoring system . RESULTS The majority of specimens showed complete dentinal bridge formation and an absence of inflammatory pulp response . Layers of well-arranged odontoblast and odontoblast-like cells were found to form tubular dentin under the osteodentin . Statistical analysis showed no significant differences between the Biodentine and MTA experimental groups during the observation period . CONCLUSIONS Within the limitations of this study , Biodentine had a similar efficacy in the clinical setting and may be considered an interesting alternative to MTA in pulp-capping treatment during vital pulp therapy PURPOSE The purpose of this study was to compare the clinical and radiographic success of Biodentine ™ and mineral trioxide aggregate ( MTA ) pulpotomy in primary molars . METHODS Thirty-two four- to nine-year-olds were included in this study . The primary molars were r and omly assigned to the Biodentine ™ and MTA groups . After coronal pulp removal and hemostasis , the remaining pulp tissue was covered with Biodentine ™ or MTA . All teeth were restored with stainless steel crowns . Clinical and radiographic successes and failures were recorded at six- , 12- , 18- and 24-month follow-ups . Data were statistically analyzed using Mann-Whitney U and Wilcoxon tests . RESULTS The 24-month follow-up evaluations revealed that the clinical success rates were 96.8 percent ( 30 out of 31 ) for both Biodentine ™ and MTA . The radiographic success rates at 24 months were 93.6 percent ( 29 out of 31 ) for Biodentine ™ and 87.1 percent ( 27 out of 31 ) for MTA . No significant differences were found among the groups at all follow-up appointments ( P>0.05 ) Conclusion : Biodentine ™ and mineral trioxide aggregate did not differ significantly in combined clinical and radiographic success after 24 months INTRODUCTION Pulpotomy technique basically consists of removing the coronal pulp and fixing the radicular pulp with a medicament . It is the most widely accepted clinical procedure for treating primary teeth with coronal pulp inflammation caused by caries with no involvement of the radicular pulp . AIM To evaluate the success and efficacy of Mineral Trioxide Aggregate ( MTA ) , Lasers and Biodentine as pulpotomy agents both clinical ly and radiographically . MATERIAL S AND METHODS In the present study , 60 primary molars in children whose pulpal status warranted pulpotomy were selected and r and omly assigned into three groups that included MTA , Laser and Biodentine allocating 20 teeth to each group . The pulpotomy procedure was then performed on all selected teeth followed by restoration with stainless steel crowns . Later the patients were recalled for 3 months and 6 months for clinical and radiographic evaluation . RESULTS Statistical analysis was done using Fisher exact test to determine pair wise comparison of three agents with respect to clinical and radiographic criteria . Kruskal-Wallis ANOVA , Mc Nemars test was applied to evaluate the efficacy of each agent between 3 months and 6 months . The results showed that maximum success rate was found in MTA group . However , the comparison between three groups was statistically not significant ( p<0.05 ) . CONCLUSION Pulpotomies performed with either MTA , Laser or Biodentine are equally efficient with similar clinical /radiographic success and hence can be considered as alternatives to Formocresol Introduction : The aim of this quantitative systematic review /meta- analysis was to compare the treatment outcomes of mineral trioxide aggregate ( MTA ) and calcium hydroxide ( CH ) in pulpotomy of human primary molars . The focused PICO question was “ in case of pulp exposure in vital primary molars , how does MTA pulpotomy compare to CH in terms of clinical /radiographic success ? ” Methods and Material s : We retrieved published r and omized clinical trials ( RCTs ) of at least 6-month duration ; our search included articles published up to March 2013 in five following data bases : PubMed ( Medline ) , Cochrane data base of systematic review s , Science Citation Index , EMBASE , and Google Scholar . Mantel Haenszel and Inverse Variance-weighted methods were applied by STATA ; the relative risk ( RR ) was calculated with 95 % confidence intervals ( CI ) . Results : A total of 282 English articles were collected . Two authors independently screened the articles and five RCTs were selected ; data extraction and quality assessment were then carried out . Four RCTs were appropriate for meta- analysis according to their follow-up times by Mantel Haenszel method . Statistically significant difference was found between success rate of MTA compared to CH , with RR=0.08 ( 95 % CI , 0.02 - 0.39 ) , RR=0.19 ( 95 % CI , 0.08 - 0.46 ) , and RR=0.38 ( 95 % CI , 0.21 - 0.68 ) for 6- , 12- , and 24-month follow-ups , respectively . A significant difference was also observed for all included RCTs after analyses using the Inverse Variance-weighted method ( RR=0.44 ; 95 % CI , 0.27 - 0.72 ) . Conclusions : Systematic review /meta- analysis of included RCTs revealed that for pulpotomy of vital primary molars , MTA has better treatment outcomes compared to CH OBJECTIVE To compare the effects of mineral trioxide aggregate ( MTA ) and calcium hydroxide ( CH ) for pulpotomy in primary molars . METHODS A r and omised , bilateral self-controlled clinical trial was design ed to compare the clinical effect of MTA and CH in pulpotomies in primary molars in 4- to 9-year-old children . Children with two similar-sized cavities on bilateral primary molar counterparts requiring pulpotomies were included . The two contralateral molars in each patient were r and omly assigned to MTA or CH treatment . Clinical and radiographic examinations were performed to evaluate the treatment results at post-treatment recall . RESULTS Seventeen pairs of self-controlled contralateral teeth were available for follow-up evaluations . The success rate of MTA was 94.1 % ( 16/17 ) , while the success rate of CH was 64.7 % ( 11/17 ) . Internal root resorption was the most frequent reason for failure in the CH group . Crown discolouration was common in the MTA-treated group . CONCLUSION MTA was more successful than CH for pulpotomies in primary molar teeth , and may be a suitable replacement for CH in primary molar pulpotomies
target: TSA indicated lack of firm evidence for the results of the meta‐analytic outcomes on clinical and radiographic success .
  Conclusion BD and MTA have similar clinical and radiographic success rates based on limited and low‐ quality evidence .
background: Objectives Pulpotomy is the favored treatment for pulp exposure in carious primary teeth .
  This review aim ed to compare the success rates of biodentine ( BD ) and mineral trioxide aggregate ( MTA ) pulpotomies  in primary molars using meta‐ analysis ( MA ) and trial sequential analysis ( TSA ) and also to assess the quality of the results by Grading of Recommendations , Assessment , Development and Evaluation ( GRADE ) .