Atp er fremstillet af aldehyd og phosphatforbindelser?
Glycerol 3-phosphate
Glycerol-3-fosfatdehydrogenaser er placeret både i cytosolen og i den indre mitokondriemembranens intermembranflade. Glycerol-3-fosfat (G3P) og dihydroxyacetonphosphat (DHAP) er så små molekyler, at de kan trænge gennem mitokondriernes ydre membran gennem poriner og pendle mellem to dehydrogenaser. Ved hjælp af dette shuttlesystem reoxideres NADH, der genereres af cytosoliske metabolismer, herunder glykolyse, til NAD+, der reducerer DHAP til G3P, og den reducerende ækvivalent kan anvendes til at generere en protonegradient over den indre mitokondriemembran ved at koble og oxidere G3P og reducerende quinon.
Glycerol-3-phosphate dehydrogenases are located both in the cytosol and the intermembrane face of mitochondrial inner membrane. Glycerol 3-phosphate (G3P) and dihydroxyacetone phosphate (DHAP) are molecules so small that they can permeate the mitochondrial outer membrane through porins and shuttle between two dehydrogenases. Using this shuttle system, NADH generated by cytosolic metabolisms including glycolysis is reoxidized to NAD+ reducing DHAP to G3P, and the reducing equivalent can be used for generating a proton gradient across the mitochondrial inner membrane by coupling and oxidizing G3P and reducing quinone.
Glycerol 3-phosphate