Postmodern terrorism presents a significant challenge to global security and law enforcement institutions. Non-state actors operating across international borders, engaged in an apparent global insurgency of extremism that transects the traditional boundaries of crime and war, pose significant challenges to both intelligence and law enforcement agencies. These networked global insurgents blend political and religious fanaticism with criminal enterprises to challenge the rule of law and pose an epochal shift in the structures and relations among states. Negotiating this epochal shift requires traditional organs of national security (the diplomatic, military and intelligence services) to forge new partnerships with police and public safety organizations at the state and local (sub-national), as well as transnational levels. Significant operational, policy and cultural challenges must be overcome to forge an effective multi-lateral global network to counter global terrorism and insurgency.