In the last few years, significant progress has been made by the Republic of Bulgaria in relation to combating crime and enforcing the rule of law. As a result of the excellent interaction between the judiciary, presented by the Prosecutor's Office of the Republic of Bulgaria on the one hand, and the executive, presented by the Ministry of Interior Bodies, State Agency for National Security, Commission for Anti-corruption and illegal assets forfeiture (CACIAF), and other institutions, a number of actions have been taken to prosecute a number of persons occupying high state positions for corruption crimes committed by them. The present study tries to make a brief analysis of the factors of current and long-term importance for the effectiveness of the Bulgarian Prosecutor's Office in combating crime and to try to find an answer to the new challenges facing the Bulgarian Prosecutor's Office.