Would they make teaching and learning more effective, more relevant, and more enjoyable? The Catalyst Initiative is an education grant programme initiated and supported by Hewlett Packard’s (HP) Sustainability and Social Innovation team. Many education systems increasingly recognise the importance of developing students’ skills and understanding for tomorrow’s innovation societies. Catalyst projects explore how innovative pedagogic models supported by technology might help develop student skills and understanding within science, technology, engineering and mathematics (STEM) subjects. Moreover, the HP Catalyst Initiative is an excellent example of how partners from the industry can help to foster innovation in education. This chapter will discuss some innovative examples of successful technology-supported teaching and learning interventions, based on the OECD/CERI work on the HP Catalyst Initiative.