The text describes the main progress in depicting the LGBTI topic in the Inter-American area. It begins with the analysis of some conceptual issues that are crossed to the topic and discuss the importance of including political commitments and statements in the resolutions adopted by the General Assembly of OAS (Organization of American States) related to the LGTBI community protection. Even though, a few cases have gone to the Inter-American Commission on Human Rights, some landmark cases have deserved the Inter-American Court of Human Rights opinion. This produces an interesting case law on the matter. Finally, the text covers the latest Inter-American Convention on human rights adopted by the General Assembly of OAS in 2013, which includes the LGBTI community. That Conventionconstitutes the first regional treaty in force on the matter.