The region of North America, Latin America and the Caribbean has a number of interregional treaties and bodies that impact older people’s human rights. This chapter explores the human rights instruments adopted in the framework of the Organization of American States, a regional organization comprised of all states of the region, as they apply to older persons. Moreover, it extensively covers the interpretation of the regional bodies that have jurisdiction to apply those human rights treaties and discusses the case law and practice applicable to the protection of human rights of older persons. In addition, this chapter includes the relevant discussions regarding the current negotiations on the adoption of an Inter-American Convention on the Human Rights of Older Persons.