Diabetes is a syndrome constituting a general public health problem and it’sdifficult fordiabetic individual, their family to adhere to self-management and person with diabetes may face many barriers to perform optimal diabetes self-management. Theaim of the studywas to assess barriers to self-management among patients with type 2diabetes mellitus (T2DM). Materials and method: Descriptive research design was utilized to conduct this study. Sample: convenience sample of 100 adult patients from both sexesdiagnosed with T2DM conducted in diabetic unit and clinicat specialized medical hospital in Mansoura University Hospital. Data were collecting using two tools, first tool was patient’s health relevant information interviewand second tool was patient's barriers to self-management. Result: There are many barriers affecting type 2 diabeticpatientsto participate in self-management and majority of the patients have insufficientor lack of adherence to self – managements and facing many barriers as educational, physical, psychosocial, financial and cultural barriers.