There is now considerable experience with issues related to the establishment of public-private partnerships in biomedical research and health innovation, and efficiency and effectiveness lessons can be learned from existing partnerships concerned with Alzheimer’s disease. Professional management of partnerships is a prerequisite for the efficient use of limited resources and the generation of value out of collaborative efforts. In order to leverage the full spectmm of advantages of public-private partnerships in Alzheimer’s disease, the issues and needs, ideologies, and objectives of each individual stakeholder need to be addressed upfront.