Gyllensten et al (2014) estimated the direct financial impact of ADEs in Sweden. Assuming that at least half of these ADEs originate in primary and ambulatory care, this corresponded to USD10.5 million per 100 000 population in 2008, which equates to approximately 2.5% of Swedish health expenditure in 2008. Hospitalisation accounted for 54% of the direct cost of ADEs.