Question: Which of the following clinical situations carries a greater risk of progression of chronic kidney disease and would require more strict control by the nephrologist? 
 Options:  <1> Diabetic patient with a glomerular filtration rate of 46 mL / min and a urine albumin / creatinine ratio of 25 mg / g. <2> Diabetic patient with a glomerular filtration rate of 89 mL / min and urine albumin / creatinine ratio of 475 mg / g. <3> Hypertensive patient with glomerular filtration rate of 65 mL / min and urine albumin / creatinine ratio of 150 mg / g. <4> A 70-year-old hypertensive patient with 1 simple cyst in each kidney, a glomerular filtration rate of 35 mL / min and an albumin / creatinine ratio in urine of 10 mg / g. <5> An 87-year-old hypertensive patient with a glomerular filtration rate of 30 mL / min and a urine albumin / creatinine ratio of 5 mg / g.
2