Question: A 62-year-old man with type 2 diabetes mellitus of 10 years of evolution performs treatment with metformin and sitagliptin. Does little physical exercise and performs a proper diet. In the last 6 months he has lost weight and has more asthenia. Their glycemic controls have deteriorated, going from basal glycemia of 110-140 mg / dl to glycemias of 170-200 mg / dl, as well as their glycosylated hemoglobin, which has gone from 7.1 to 8.5%. The most appropriate therapeutic measure to perform is: 
 Options:  <1> Increase the intake of protein and long chain carbohydrates in the diet to improve asthenia and weight loss. <2> Associate a dose of basal insulin with the treatment. <3> Associate acarbose treatment. <4> Replace sitagliptin with pioglitazone. <5> Replace metformin with glimepiride.
2