Question: The main indication for using 4 drugs in the initial treatment of tuberculosis is: 
 Options:  <1> Affectation of the central nervous system. <2> High prevalence of primary resistance to isoniazid. <3> Cavitated and extensive pulmonary tuberculosis with large bacillary load. <4> Disseminated tuberculosis associated with HIV infection. <5> Extrapulmonary tuberculosis in immunodepressed patients of any origin.
2