Question: A 29-year-old woman with a history of abundant rules and long-standing iron-deficiency anemia who have required treatment with ferrotherapy since she was 17 years old. Consult because after a tooth extraction you have hemorrhage that has required local hemostatic treatment. He relates that a maternal aunt presents frequent epistaxis. In analytical presents: 8000 leukocytes / uL, Hb 10.7 g / dL, VCM 76 fL, 380,000 platelets / uL; the biochemistry is normal. Prothrombin activity 90%; INR 0.9; Activated Partial Thromboplastin Time (APTT) 48 sec (39 sec) with an APTT ratio of 1.3 and fibrinogen derivative 340 mg / dL. What is the most likely diagnostic suspicion and how would it confirm it? 
 Options:  <1> Hemophilia A and mixtures test. <2> Lupus anticoagulant and ANAS study. <3> Sideroblastic anemia and spinal aspiration. <4> Congenital thrombocytopathy and study of platelet aggregation. <5> Von Willebrand disease and determination of factor vW.
5