Question: A patient with a history of excessive alcohol consumption has been diagnosed with pulmonary tuberculosis due to cough, fever, expectoration, and isolation in the Mycobacterium tuberculosis sputum culture. The patient has begun treatment with isoniazid, rifampin, ethambutol and pyrazinamide, with adequate tolerance. A report of resistance to rifampicin of M. tuberculosis isolated in the sputum is received 20 days after the start of treatment. What regime would you select based on this report? 
 Options:  <1> Isoniazid, ethambutol, pyrazinamide for 12 months. <2> Isoniazid, ethambutol, pyrazinamide for 12 months and streptomycin for two months. <3> Isoniazid, ethambutol, pyrazinamide for 12 months and a quinolone for two months. <4> Isoniazid, ethambutol, pyrazinamide and a quinolone for 18 months. <5> Isoniazid, ethambutol, pyrazinamide for 18 months and streptomycin and a quinolone for two months.
4