Question: Which of the following statements related to breast cancer is correct ?: 
 Options:  <1> Infiltrative ductal carcinoma is the least frequent histological type (around 510%) <2> If the tumor is located in the nipple, it is called Paget's disease. <3> Total mastectomy involves excision of the breast, the areola-nipple complex, and axillary lymph node dissection. <4> It does not produce metastasis in the bone tissue. <5> When there is metastasis, hormone therapy is contraindicated.
2