Question: Which statement regarding the substitution treatment with L-thyroxine in a patient with hypothyroidism is correct? 
 Options:  <1> Thyroid function will be determined 48 hours after its initiation to assess efficacy. <2> In elderly patients and in order to improve symptomatology quickly, treatment with L-T4 is started at a dose of 150-200 micrograms per day. <3> In pregnancy, thyroid hormone requirements usually increase by about 50 micrograms per day, over the previous dose. <4> The medication should be taken in the middle of meals. <5> It is advisable to administer a gastric protector simultaneously to avoid gastritis.
3