Question: In relation to Hereditary Spherocytosis it is true that: 
 Options:  <1> It is a congenital hemolytic anemia of inheritance linked to the X chromosome that causes severe anemia. <2> It is characterized by a decrease in osmotic fragility. <3> It manifests as episodes of acute medication anemia. <4> Splenectomy is the treatment of choice when it is symptomatic. <5> It is rarely associated with cholelithiasis.
4