Question: Mr. X is a 67-year-old patient who has been prescribed atorvastatin orally due to high cholesterol levels that have not improved after dietary measures. Among the clinical applications of the HMG-CoA reductase inhibitors we have: 
 Options:  <1> They are the drugs of choice in the case of pregnant women. <2> They are drugs of first choice in the treatment of hypertriglyceridemia. <3> They are not effective in the secondary prevention of myocardial infarction. <4> In severe dyslipidemias, in the case of heterozygous familial hypercholesterolemia, they should be combined with ezetimibe. <5> They are not effective in the secondary prevention of stroke.
4