Question: In the treatment of major depressive disorder, what are the advantages of selective serotonin reuptake inhibitors (SSRIs) compared to tricyclic antidepressants? 
 Options:  <1> They are more effective. <2> They have been used for a longer time, while tricyclic antidepressants are more modern and are not well known. <3> They have fewer side effects. <4> Its efficacy has been proven in controlled studies, while tricyclic antidepressants have not yet been evaluated in controlled studies. <5> They have no clear advantage.
3