Question: NOT true about Rheumatoid Arthritis: 
 Options:  <1> Early diagnosis, intensive treatment and close control of the disease are essential. <2> Methotrexate is the drug of first choice to control the activity of the disease. <3> The rheumatoid factor is typical of the disease and is a mandatory criterion for diagnosis. <4> The specificity of citrullinated peptide antibodies is very high and has a prognostic value. <5> Biological drugs, such as anti TNF, have revolutionized the treatment.
3