Question: In a clinical trial of an antineoplastic drug, a significant increase in plasma levels of LDL (low density lipoproteins) is observed. Indicate among the following statements which is correct in the interpretation and consequences of this fact: 
 Options:  <1> LDL represents the transport mode of cholesterol from the intestine to the liver. Therefore, they reflect a greater incorporation of cholesterol from lipid intake. <2> LDL is involved in the reverse transport of cholesterol from peripheral tissues to the liver. Therefore, high levels are beneficial for lowering plasma cholesterol levels. <3> LDL are rich in triglycerides and low in cholesterol. An increase in plasma LDL reflects an increase in de novo synthesis and / or ingestion of triglycerides. <4> An increase in plasma LDL levels is beneficial because it protects the arteries from the formation of atherosclerotic plaques. <5> LDL transport cholesterol from the liver to peripheral tissues, where they enter the cells through endocytosis processes.
5