Question: The brain alterations that characterize Alzheimer's disease are: 
 Options:  <1> Hyperactivation of the dopaminergic neurons of the basal ganglia, causing neuronal death. <2> Degeneration of the hippocampus, and of the cortex of the frontal and temporal lobes. <3> Deterioration of the serotonergic neurons of the parietal and occipital lobes. <4> Presence of Lewy bodies in all subcortical white matter. <5> Accumulation of denatured prion proteins that cause inflammation in the frontal and parietal lobes.
2