Question: The access of drugs to the central Nervous System is conditioned by the existence of the blood-brain barrier (BHE) barrier: 
 Options:  <1> Increases its permeability in case of inflammation. <2> It is homogeneous throughout the encephalon. <3> It is traversed freely by fat-soluble drugs. <4> It is maximum in the chemoreceptor area of ​​the trigger. <5> Decreases its permeability in case of inflammation.
1