Question: A 30-year-old man (index case) affected by Leber's optic atrophy presents the mutation of the mitochondrial genome LHON11778A. In genetic counseling you will be informed of the risks of transmitting the disease to your offspring. What information is correct? 
 Options:  <1> The index case will transmit the disease to all its male descendants (holándrica inheritance). <2> The disease will be transmitted to 50% of the descendants of the index case, regardless of their sex. <3> The disease will be transmitted to all descendants of the index case, as it is of paternal inheritance. <4> The disease will be transmitted to female descendants; but to no man. <5> The disease will not be transmitted to the descendants of the index case, because it is of maternal inheritance.
5