John is playing a game in which he tries to obtain the highest number possible. He must put the symbols +, $\times$, and - (plus, times, and minus) in the following blanks, using each symbol exactly once:\[2 \underline{\hphantom{8}} 4 \underline{\hphantom{8}} 6 \underline{\hphantom{8}} 8.\] John cannot use parentheses or rearrange the numbers. What is the highest possible number that John could obtain?
(A)22 (B)46 (C)100 (D)99
B