Question: A 37-year-old woman with an extensive ulcerative colitis has a severe outbreak where treatment with prednisone is started at a dose of 1 mg / kg. After a week of treatment, the patient does not show improvement. What is the next therapeutic measure to perform? 
 Options:  <1> Subtotal colectomy of urgency and in a second time proctectomy and ileoanal reservoir. <2> Associate an immunosuppressant such as azathioprine. <3> Associate mesalazine in doses of 4 grams per day oral and rectal triamcinolone 1 application every 12 hours <4> Endovenous cyclosporine 2 mg / Kg. <5> Treatment with etanercept (an anti-TNFa antibody) should be assessed.
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