Question: Regarding the Gastrointestinal Stromal Tumors (GIST), it is true that: 
 Options:  <1> These are tumors of epithelial origin, located mainly at the level of the mucosa of the digestive tract. <2> The mutation of the c-kit gene, which codes for a tyrosine kinase receptor, is characteristic of these tumors. <3> The treatment of localized tumors smaller than 2 cm is fundamentally medical, with the use of Imatinib. <4> They are tumors that only exceptionally bleed. <5> The most frequent localization of these tumors is the small intestine.
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