Question: When comparing the characteristics of pragmatic or confirmatory clinical studies with explanatory or exploratory clinical studies, which of the following is an advantage of the former? 
 Options:  <1> Information about subgroups of patients representative of the usual clinical practice. <2> Very homogeneous sample, with little variability. <3> Greater capacity to detect differences in the effectiveness of interventions. <4> Greater internal validity <5> Smaller sample size
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