Fifty-eight-year-old woman with 2 cancers: one seen on DBT but not visible with US, and one seen on US but not on DBT. She presented for screening with DBT. (A) Right 2D MLO view was negative, but asymmetry was seen (B) medially on the craniocaudal (CC) view. DBT (C) MLO and (D) CC views show architectural distortion (arrows) in the upper inner quadrant. US was negative in the upper inner quadrant (no image), but showed a suspicious mass in the 9 o’clock position (arrows in (E). (F) The upper inner quadrant mass was biopsied with DBT-guidance (scout view) and was an invasive lobular carcinoma. The 9 o’clock mass was biopsied with US-guidance and was an invasive ductal carcinoma.