A chest X-ray was performed at admission, showing scattered nodular opacities in the left lung upper lobe and right lung lower lobe, which indicated a central area of excavation (arrows). 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has increasingly been used to manage cancers and infections [1,2,3]. Since FDG uptake is directly representative of glucose metabolism, it can increase in inflammatory cells as well as tumor cells. Long-term indwelling central venous catheters are necessary for treating cancer patients due to chemotherapy. They depend on their central venous catheters daily, which could predispose a significant risk of complications such as catheter-related bloodstream infection (CRBSI) [4,5,6]. CRBSI can be complicated by metastatic infectious foci associated with a high morbidity and mortality rate, which should require prolonged systemic antimicrobial treatment [7]. The significant complication of CRBSI is septic thrombosis, with a prevalence of 15~24% [8,9]. The clinical diagnosis of septic foci is critical but may be difficult to establish due to the challenge of determining between sterile catheter-related thrombosis and actual septic thrombosis. Additionally, symptoms are often non-specific, and there is a lack of sensitivity to conventional diagnostic imaging techniques. Only a few studies investigated that 18F-FDG PET/CT can find the infectious foci, demonstrating it as an accurate imaging modality for metastatic foci [10,11,12]. Here, we would like to report a female patient with a Staphylococcus aureus-implantable venous access catheter infection in which 18F-FDG PET/CT determined unsuspected septic pulmonary emboli. A 71-year-old female patient with known ovarian cancer visited our hospital to receive the 4th adjuvant chemotherapy. She was treated with total abdominal hysterectomy, bilateral salpingo-oophrectomy and omentectomy 6 months ago. She also had a history of central venous catheterization by the right internal jugular vein approach, terminating at the junction of the superior vena cava and right atrium. The adjuvant chemotherapy was already performed three times as the regimen of Paclitaxel plus Carboplatine after surgery. At admission, she presented no clinical symptoms such as fever, cough, sputum, dyspnea, or chest pain. However, the chest X-ray showed scattered nodular opacities in the left lung upper lobe and right lung lower lobe, suspicious of metastatic nodules (Figure 1). Her blood test showed unexplained leukocytosis (12.58 × 103/μL), elevated D-dimer (9.46 mg/L), and a tumor marker such as CA-125 (41.89 U/mL). 18F-FDG PET/CT was performed 2 days after admission, observing abnormal FDG uptake in the chemo-port catheter, right pectoralis muscle, and 1st costochondral junction (Figure 2a–d). PET/CT also revealed hypermetabolic nodules scattered throughout both lungs, consistent with septic embolism (Figure 2e). In the evening of the day of the PET/CT examination, the patient presented swelling, redness, and some discomfort at the catheter insertion site. The catheter was removed the next day, isolating methicillin-sensitive Staphylococcus aureus from the catheter tip and peripheral vein. A transthoracic echocardiogram and fundus examination, which were performed to evaluate possible metastatic infections such as infective endocarditis or endophthalmitis, were reported as normal. She was treated with intravenous cefazolin for 4 weeks followed by oral linezolid for 1 week, recovering uneventfully without relapse. She was also treated with rivaroxaban 15 mg for 3 weeks and was diagnosed with pulmonary thromboembolism. After 2 months, a follow-up chest CT showed that the pre-existing multiple nodules in both lungs had disappeared (Figure 3).