Hepatocellular carcinoma in the non-cirrhotic liver in a 65-year-old male patient. B-mode ultrasound (BMUS) displayed a hyperechoic focal liver lesion in the right lobe of the non-cirrhotic liver, with an ill-defined margin and irregular shape (A). Dotted color flow signals could be detected inside the lesion (B). On Sonazoid-enhanced contrast-enhanced ultrasound (CEUS), the lesion showed heterogeneous hyperenhancement during the arterial phase (C) and relatively early washout (23 s after the injection of Sonazoid). The lesion showed hypoenhancement during the portal venous phase (D), late phase (E), and Kupffer phase (F).