Maximum intensity projection of CXCR4-directed PET/CT with [68Ga]Pentixafor in a 67-year-old patient with acute COVID-19 infection. Beyond bilateral pneumonia with reactive hilar and mediastinal lymph nodes, inflammatory foci in the lymphoid tissue of the neck could be depicted. In addition, the reactive activation of both bone marrow and spleen is visualized. The patient’s condition deteriorated quickly after imaging and he was transferred to the ICU on the day after PET/CT [C. Lapa, unpublished data].