61-year-old man with 11 mm adenocarcinoma in right upper lobe. There is one computer-aided detection (CAD) mark in right upper lobe which is true positive. At initial reading, two radiologists and one resident detected true lesion. After review of CAD marks, two radiologists and two residents accepted true CAD mark, while one radiologist and two residents rejected true CAD mark. Two residents detected one false positive lesion each, but rejected false positive lesion after review of CAD marks.