Example of Region of interest (RoI) definition for a bone PET/CT hotspot in InterView FUSION Software. The 2D slice includes the defused PET uptake (kidneys and bone metastasis in dark blue, green, yellow, and red) co-registered with the CT image (in grayscale). The blue contour around the metastatic uptake is defined and named (Bone 11) by the NM expert.