ADC histogram analysis parameters and histopathological findings in a large oral/oropharynx squamous cell carcinoma(A) T1 weighted image after intravenous administration of contrast medium showing a large oral lesion (arrow). (B) ADC map of the tumor with a ROI. (C) ADC histogram. The histogram analysis parameters (× 10-3 mm2s-1) are as follows: ADCmin = 0.45, ADCmean = 0.95, ADCmax = 1.54, P10 = 0.74, P25 = 0.83, P75 = 1.05, P90 = 1.14, median = 0.95, mode = 0.98, and standard deviation = 0.17. Addionally, histogram-based characteristics are as follows: kurtosis = 3.43, skewness = 0.09, and entropy = 3.75. (D) Histopathological investigation after tumor biopsy. Immunohistochemical stain (MIB-1 monoclonal antibody). Ki 67 index is 86%, cell count is 190, total nucleic area = 58127 μm2, and average nucleic area = 310 μm2