A dosimetric simulation study of the SBRT dose-escalation approach with Simultaneous Integrated Boost (SIB) and Simultaneous Integrated Protection (SIP) for LAPC. This example demonstrates excellent coverage of target volumes and respect of OARs (duodenum = black, bowel = light green, and stomach = pink). The PTV40Gy (red) is created by adding 5 mm to the integrated gross target volume (iGTV) structure. The PTV60Gy (blue) is generated to cover the tumor vessel interface (TVI) inside the iGTV, while the PTV33Gy (dark green) corresponds to the overlap area between the PTV40Gy and PRV OARs (luminal OARs + 3 mm).