Figure 1. Patients 1 (A), 2 (B), 3 (C) and  4 (D). The patients exhibited the physical findings of  3M syndrome: Dolichocephaly, high and broadforehead, upswept posterior hairline (in patients 1 and 2), downward slanting of the eyes, horizontal eyebrows, flat nasal bridge, narrowed and short nasal body, prominent fleshy nasal tip, straight clavicles, high and square shoulders, short, wide and flat thorax with a mild pectus excavatum