MRI performed for a seventy-three-year-old man presented to the emergency department with bilateral muscular weakness members, cognitive disorders and KPS of 60.The T1W sequence with gadolinium injection showed a large bifrontal GBM invading the corpus callosum. Stereotactic biopsy revealed the presence of a glioblastoma multiforme (confirmed by independent reviewing). This patient had almost all factors of poor prognosis (sex, age, low KPS, tumor localization, no surgical treatment) but received concomittant radiochemotherapy with temozolomide and survived 4 years.