Examples of X-ray pathological changes of an eight-year old KBD boy. A A large defect with cone shaped showed in metaphysis alterations. There is an early closure of epiphysis line; B A large defect in metaphysis; C Cone shaped epiphysis; D Sclerosis in bottom of metacarpal bone; E Irregular marginal with sclerosis in carpal; F A large defect with sclerosis in carpal