72-year-old woman with 16 mm adenocarcinoma in left lower lobe. There are four computer-aided detection (CAD) marks among which only mark in left lower lung is true positive. Small calcified nodule in right upper lobe was excluded from analysis. At initial reading, three radiologists and two residents detected true lesion. After review of CAD marks, one radiologist and two residents accepted true CAD mark, while one radiologist and one resident rejected true CAD mark. One resident detected one false positive lesion and added one more false positive lesion after review of CAD marks.