Alignment variables were obtained using Medicaid® Classic (Hectec GMBH) for all individuals within the cohort. Mechanical alignment measurements included weight-bearing axis (WBA), mechanical lateral proximal femoral angle (mLPFA), mechanical lateral distal femoral angle (mLDFA), medial proximal tibial angle (MPTA), mechanical lateral distal tibial angle (mLDTA) and joint line convergence angle (JLCA). The light blue line indicates the weight-bearing axis expressed as a percentage of the medial–lateral tibial plateau (35.3% in this plan). NB: the outline of the femur and tibia has been highlighted in white to aid interpretation of this figure