Endoscopic ultrasound picture of a pancreatic solid tumor: the pancreatic tumor appears as a hypoechoic round lesion; the needle biopsy is clearly seen within the tumors (EUS = ultrasonic probe). The scheme illustrates all analyses offered by fine needle biopsy: histology on microbiopsy, DNA and/or RNA extractions on cellular sample obtained after air blushing or rinsing needle after core biopsy reclaim.