Sonomorphological features and histopathological assessment of poorly differentiated hepatocellular carcinoma (HCC). (a) Homogeneous, hyperechoic liver lesion in native B-mode (yellow arrow). (b) The lesion shows peripheral hypervascularization in Doppler mode (yellow arrow). (c) In CEUS, peripheral rim contrast enhancement was detected in the arterial phase (yellow arrow). (d) In the late venous phase, the lesion showed typical rapid wash-out (yellow arrow), thus indicating HCC. (e) Hematoxylin and Eosin staining of the suspicious lesion, 20× magnification. Poorly differentiated hepatocellular carcinoma with concomitant necrosis (black star) and fibrous septa (black arrow) is shown.