Point-of-care ultrasonography image demonstrating the “whirlpool sign” (arrows) over the mesenteric vessels as indicated by their presentation in a spiral shape. Abdominal pain is the most common complaint in the emergency department (ED) [1,2]. Acute abdominal pain can be caused by a spectrum of conditions ranging from benign and self-limited diseases to surgical emergencies. Abdominal pain is caused by a variety of gastrointestinal and non-gastrointestinal disorders. Some frequently missed conditions include biliary pathology, appendicitis [3], diverticulitis, urogenital pathology, and even vascular emergency [1]. Therefore, the rapid and early detection of urgent conditions is crucial for managing patients efficiently. The combination of clinical and laboratory evaluation cannot reliably predict or exclude urgent conditions and can result in unnecessary or delayed interventions. Further diagnostic imaging such as point-of-care ultrasonography (POCUS) can help in the early identification of the cause of abdominal pain [4,5] and increase the certainty of the diagnosis [6]. The American College of Emergency Physicians (ACEP) defines clinical ultrasonography as a diagnostic modality that provides clinically significant data that are not obtainable by inspection, palpation, auscultation, or other components of the physical examination [7]. POCUS performed and interpreted by physicians at the bedside has grown rapidly in recent decades [8], as current ultrasound equipment has become less expensive, higher quality and more compact. The use of bedside ultrasonography (or insonation), incorporated with traditional inspection, palpation, percussion, and auscultation have become the five pillars of bedside clinical medicine [9]. As an extension of the physical examination [10], a more generalized concept of an “ultrasound stethoscope” is used to provide directed clinical assessments [11,12]. It could provide immediate, real-time dynamic images that are correlated with a patient’s clinical condition and are easily repeatable. The main goal of POCUS in ED is to rapidly rule in or rule out a dangerous diagnosis and to solve clinical problems, such as evaluating the cause of shock [13]; shortness of breath [14]; chest pain; fever; and muscular, skeleton, or soft tissue swelling and pain [15,16] before laboratory tests. It can also help to guide the procedure [17,18] and allow checking for complications to promote patient safety [19]. Moreover, it can be used as a first-line tool for the evaluation of abdominal pain after taking the patient’s history and conducting a physical examination [4,5,20,21]. The use of ultrasonography can enable the detection of urgent conditions in patients with acute abdominal pain and can decrease unnecessary radiation exposure [6], decrease the need for further examinations, and decrease the frequency with which patients are admitted [22]. Nevertheless, ultrasonography is an extremely operator-dependent modality of testing. Acquiring the skills to properly manipulate and interpret images for safe integration with clinical work takes years to master [20,23]. There are many factors that can affect the quality of POCUS and the decision making involved, such as patient factors, the operator’s skills in image acquisition and interpretation, and machine quality [11]. It is important to be able to identify and differentiate artifacts and false positives and negatives to overcome the pitfalls of POCUS [24,25]. Therefore, POCUS education has been integrated into postgraduate-year training, and emergency resident training is important. It will result in physicians having more self-confidence to overcome the barriers for implementing POCUS in clinical practice. Here, we present an unusual case of abdominal pain after jejunostomy tube insertion with the use of POCUS for diagnosis. A 51-year-old male with a history of esophageal cancer presented to the emergency department due to a jejunostomy tube that had been accidentally dislodged without causing abdominal pain and hemodynamically stable. A few minutes after the introduction of a new tube, the patient complained of diffuse abdominal pain. Upon examination, his body temperature was 36.6 °C, his pulse rate was 79 beats per minute, his blood pressure was 90/45 mmHg, and his respiratory rate was 18 breaths per minute. The physical examination revealed a soft abdomen without rebounding tenderness or muscle guarding. The jejunostomy tube functioned well, and laboratory tests were unremarkable. The source of abdominal pain was considered benign. However, analgesic agents could not relieve abdominal pain. We performed POCUS for persistent abdominal pain to rule out bowel perforation or other dangerous etiology such as vascular emergencies, and it demonstrated mesenteric vessels presenting in a whirlpool sign, namely, in a whirling or spiral shape (Figure 1, Video S1). We tried to remove the tube; however, it could not be moved and induced progressive pain. It prompted the use of computed tomography (CT) (Figure 2, Video S2). This confirmed the presence of a small-bowel volvulus with a whirlpool sign over the jejunal branches of the superior mesenteric vessels. A surgeon was consulted, and this patient underwent surgical correction of the volvulus, without subsequent complications.