
ikzf1

dna-binding protein icaros, dheenini icaros kutumbam jink finger protein 1 anie kooda pilustaaru, idhi maanavulalo "ikzf 1" janyuvu dwara encode cheyabadina protein. 
ikaros-transcription phyaaktar.
icaros anedi icaros kutumbaaniki chendina jink vaeli samuuham yokka "ikzf" janyuvula dwara encode cheyabadina oka transcription karakam. jink vaelu anedi protein yokka oka chinna nirmaanaatmaka muulaamsam, idhi madata sthireekarinchadaaniki okati ledhaa anthakante ekkuva jink ayanla (zn2 +) samanvayamtho vargeekarinchabadina DNA ledhaa rna anuvutho protein bandhinchadaaniki anumatistundi.
ikaros hematopoietic vyavasthalo keelakamaina vidhulanu pradarsistundi mariyu roganirodhaka kanaala abhivruddhiki telisina niyantrakam, pradhanamgaa prarambha bii kanaalalo, sidi4 + tii kanaalalo. daani panicheyakapovadam deerghakaalika lymphocytic leukemia abhivruddhitho mudipadi undhi. mukhyamgaa, iteevali samvatsaraalalo maanava bii-sell acute lymphoblastic leukemia palgonna pradhana kaniti anichivetagaa icaros kanugonabadindi mariyu idhi vyaktigata tii sahayaka kanaala bhedam mariyu paniteerulo kooda oka paatranu kaligi undhi.
antibody isotypes yokka switch class mariyu bii sell receptor yokka vyakteekaranalo vidije punarekeekarana samayamlo bii sell abhivruddhi yokka taruvaati dasalalo icaros kooda paatranu kaligi untundi.
ikaros nakout elukalalo, sambandhita janyuvu iolos (ikzf3) yokka aalasyamaina parihara vyakteekarana kaaranamgaa eluka abhivruddhilo tii kanaalu utpatti avtayi, conny bii kanaalu kaadu. ikaros point utparivartana elukalu raktaheenata kaaranamgaa pinda praanaantakam; avi terminal erythrocyte mariyu granulocyte bhedamlo teevramaina lopaalanu kaligi untaayi mariyu adhika macrophage erpadataayi. maanavulalo ii. keey. zii. eff. 1 yokka 3 'praantaaniki sameepamlo unna snaps baalyamlo teevramaina lymphoblastic leukemia (annee) alaage type 1 diabetisku gurayye avakaasam undhi. rendu prabhavalu vyatiraeka disalalo unnatlu kanipistaayi, yugmavikalpam tii1dii nundi rakshinche annintikee grahanaseelatanu gurtistundi mariyu dheeniki viruddhamgaa untundi.
icaros jink finger kutumba samuuham yokka janyuvulu.
transcription kaarakaala yokka ikaros jink finger (ikjf) kutumbam hematopoietic kanaala abhivruddhi mariyu sidi4 + tii kanaalatoe sahaa aneka roganirodhaka kanaala niyantrakaalu. 
ikzf kutumbamlo aiduguru sabhyulu untaru icaros ("ikzf1" janyuvu dwara encode cheyabadindi), helios ("ikzf2"), iolos ("ikzf3"), eos ("ikzf4"), mariyu pegasus ("ikzf5"). eee karakalu enn-terminal jink finger (jdf) domainlanu kaligi untaayi, ivi dnatho pratyaksha paraspara charyalaku madhyavartitvam vahinchadaaniki baadhyata vahistaayi, mariyu sii-terminal jdfs, ivi ikzf kutumba sabhyula madhya homo-mariyu heterodimyrisation sulabhataram chestaayi. 
ikzf1 granulocytelu, b kanaalu, cd4 mariyu cd8 t kanaalu mariyu nk kanaalalo niyantrinchabadutundi mariyu erythroblastlu, megacaryocytelu mariyu monocytelalo niyantrinchabadutundi. 
ikaros lopam.
ikzf1" janyuvulo utparivartana anedi icaros transcription karakam panicheyakapovadaaniki kaaranam kaavacchu. panicheyakapovadam anedi bii kanaalalo vyakteekarananu prabhaavitam chestundi, idhi bii kanaala abhivruddhi samayamlo bii. sii. aarr signalling yokka niyantrananu tolaginchadaaniki daariteestundi mariyu bii kana parivartanatho mudipadi untundi. niyantrana tolagimpu appudu takkuva vistarana raetu mariyu bii kanaala apoptosis peragadaaniki daariteestundi. niyantrana tolagimpu anedi lymphoproliferative rugmatalu mariyu vividha rakaala leukemiatho sambandham kaligi undavacchu. 
paraspara charyalu.
ikzf1 dheenitho sankarshana chendutundani choopabadindihi

