
rock3

raasku sambandhinchina sii3 botulinum taxin substrate 3 (ryaak3) anedi maanavulalo "ryaak3" janyuvu dwara encode cheyabadina zii protein. idhi intracellular signalling margalalo mukhyamaina bhaagam. rock3 anedi chinna zii proteinla roow kutumbaaniki chendina rock upakutumbamlo sabhyudu. eee suupar family sabhyulu kanaala perugudala, cytoskelital punarvyavastheekarana mariyu protein kinesla kriyaaseelata niyanthranatho sahaa vividha rakaala cellular sanghatanalanu niyantristunnatlu kanipistaaru.
paraspara charyalu.
ryaak3 anedi sib1 mariyu hcnf1eah thoo sankarshana chendutundani choopabadindi. ryaak3 kooda nrf2 proteinlatho sankarshana chendutundi. etter, ilk, mariyu β-arr1 kooda ryaaktho sankarshana chendutaayi.
sthaanam.
rock 3 janyuvu chromosome 17 paie q arm yokka rendava praantamloo aidava byaand yokka moodava upa-bandlo undhi. rock 3 janyuvu chuttoo unna aneka kaniti anichivese janyuvulu unnaayi.
chikitsa upayogam.
carcinoma kanaalalo ryaak3 janyuvu atigaa vyakteekarinchabadinanduna, idhi oopiritittula adenocarcinoma vanti vividha cancer chikitsaku chikitsa lakshyamgaa panichestundi. invasivga maaradaaniki, epithelial kanaalu messenchimal kanaalugaa maaraali mariyu parivartananu ryaka 3 janyuvu niyantristundi. phalitamgaa, ryaak3 janyuvu nissabdam cheyabadithe, oopiritittula adenocarcinoma kanaalu metastasize cheyalevu. adanamgaa, ryaka 3 janyuvunu nissabdam cheyadaaniki roopondinchina mandulu kaniti kanaala apoptosisku daariteestaayi, tadwara kanaalu valasarajyam kakunda nirodhistaayi.
pathological mutationlu.
rock3 janyuvu yokka utparivartanalu structural brain anomalis mariyu diasmorphic phesiistoe neurodevelopmental desorderku daariteeyavachchu, dheenini modata 2018loe white mariyu itarulu varninchaaru.

