gosipol

gosipol () anedi patthi mokka ("gosipium" jaathi) nundi udbhavinchina sahaja final. gosaipol anedi kanaalalo vyaapinchae phenolic aldehyde, idhi aneka dehydrogenase enjaimlaku nirodhakam vale panichestundi. idhi pasupu varnadravyam. eee nirmaanam atropisomerizanni pradarsistundi, rendu ananciomerlu ververu jeevarasaayana lakshanaalanu kaligi untaayi.
itara anuvartanaalato paatu, idhi chainaalo maga noti garbhanirodhakamgaa pareekshinchabadindi. daani sambhaavya garbhanirodhaka lakshanaalatoo paatu, gosaipol kooda malaria nirodhaka lakshanaalanu kaligi undani chaalaa kaalamgaa telisindi.
jeevasansleshanha.
gosaipol anedi terpenoid aldehyde, idhi isoprenoid maargam dwara acetate dwara jeevakriya dwara erpadutundi. sesquiterpean diamer gosaipolnu roopondinchadaaniki radikal coupling praticharyaku lonavutundi. geranil pyrophosphate (gpp) mariyu isopentinyl pyrophosphate (ipp) lanu kalipi sesquiterpean puurvagaami fornacel diphosphate (efpipi) nuu tayaaru chesinappudu jeevasansleshanha praarambhamavutundi. cadinyl katayan (1) anedi (+)-δ-cadineen synthase dwara dwara aakseekarana chendutundi. (+)-δ-cadineen (2) anedi aakseekarana dwara praathamika sugandha sesquiterpean unit, homigosaipolnu tayaaru cheyadamlo paalgontundi, idhi (+)-δ-cadineen 8-hydroxylase sahayamtho 3 (8-hydroxy-δ-cadineen) nuu utpatti chestundi. 3va sammelanam vividha aakseekarana prakriyala gundaa velli 4 (dioxyhemigosypol) nuu tayaaru chestundi, idhi oka electron dwara hemigocypol (5,6,7) gaa aakseekarana chendutundi, aapai final samuuhaalaku "ortho" anae phenolic aakseekarana kalayikaku lonavutundi, idhi gosaipol (8) nuu yerparustundi. eee kalayika hydrogen peroxide-aadhaarita peroxidase enjaim dwara utprerakam cheyabadutundi, idhi tudi utpattiki daariteestundi.
parisoedhana.
garbhanirodhakam.
garbhanirodhakam jiangjilo jarigina parisoedhanaloo magavaarilo takkuva santanotpatti mariyu vanta kosam mudi patthi vittanaala noone vadakam madhya paraspara sambandhaanni choopinchindi. garbhanirodhaka prabhaavaaniki kaaranamayye sammelanam gosipol anie nirdhaarinchabadindi.
nirdhaarinchabadindi, chaina prabhutvam garbhanirodhakamgaa gosipol vaadakampai parisoedhana praarambhinchindi. vaari adhyayanalu 10,000 vishayaalaku paiga undevi, mariyu oka dasaabdam paatu konasagayi. gosipol nammadagina garbhanirodhakatanu andinchindani, noti dwara maatragaa teesukovacchani, purushula harmonela samatulyatanu debbateeyaledani vaaru nirdhaarinchaaru.
ayithe, gosipol loe kooda teevramaina lopaalu unnaayi. adhyayanalu vishayaalalo hypocalemia (takkuva raktamlo potassium sthaayilu) asadhaaranamgaa adhika raetu (0.75%) nuu kooda kanugonnayi. hypocalemia alasata, kandaraala balaheenata mariyu daani atyanta teevramaina pakshavaatam lakshanaalanu kaligistundi. adanamgaa, sumaru 7 saatam mandhi tama jeerna vyavasthalapai prabhavalanu nivedinchaaru, sumaru 12 saatam mandhi alasatanu penchaaru, kontamandi napumsakatvaanni anubhavinchaaru ledhaa kaamasaktini tagginchaaru, mariyu 9.9 saatam mandhi kolukoleni vandhyatvaaniki gurayyaru, idhi spashtamgaa ekkuva kaalam chikitsa mariyu gosipol yokka mottam motaadutoe mudipadi undhi. chaalaa mandhi rogulu chikitsanu nilipivesi, potassium supplementlanu teesukunna tarvaata kolukunnaru. gosipol chikitsa samayamlo potassium supplementlanu teesukovadam valla primatelalo hypocalemia nirodhinchaledani adhe adhyayanam choopinchindi. potassium lopam chainees aaharam ledhaa janyu siddhata phalitamgaa kooda undavacchu.
1990la madhyalo, brazilian pharmaceutical company hebran nofertil anae takkuva motaadu gala gosipol maatranu vikrayinche pranaalikalanu prakatinchindi, conny aaa maatra eppuduu marketloki raaledu. shaashwata vandhyatvam yokka aamodayogyam kaani adhika raetla kaaranamgaa daani vidudala niravadhikamgaa vaida padindi. 5 saatam nundi 25 saatam mandhi purushulu chikitsa nilipivesina oka samvatsaram varaku ajospermicga unnaaru. 
shastrachikitsa dwara chese vasectomiki gosipol manchi noninvasive pratyamnaayamgaa undavacchani parisoedhakulu suuchimchaaru.
suuchimchaaru, chaina prajaarogya mantritva saakha mariyu rockfeller foundationlatho kalisi, prapancha aarogya samstha purushula garbhanirodhaka aushadhamgaa gosipol paie parisoedhananu nilipivese nirnayaanni lanchanaprayamga chesindi. itara dushprabhaavaalato paatu, gosipol vishapuuritam gurinchi parisoedhakulu aandolana chendaaru primatelalo garbhanirodhaka motaadu kante 10 retlu takkuva, idhi oka chinna chikitsa vindoonu srushtistundi. eee nivedika taatkaalika garbhanirodhakamgaa gosipol yokka tadupari adhyayanalanu samarthavantamgaa muginchindi, ayithe dheenini vasectomiki pratyamnaayamgaa upayoginchadampai parisoedhana austria, brazil, chilly, chaina, dominican republic mariyu nigerialo konasagutondi.
vishapuuritam.
aahara mariyu janthu vyavasaya parisramalu vishapuuritatanu nivaarinchadaaniki patthi-utpanna utpatti sthaayilanu nirvahinchaali. udaaharanaku, ruminant microflora matrame gosipolnu jeernam cheyagaladu, aapai oka nirdishta sthaayiki matrame, mariyu patthi vittanaala noonenu suddhi cheyali. vittanamlo takkuva gosipol kaligi unna janyuparamgaa injaneering cheyabadina patthi mokkalu ippatikee kaandam mariyu aakulalo sammelanaanni kaligi undavacchu.

