
hcla-drb1

hcla class II hystocompatability antigen, drb1 beata chain anedi maanavulalo "hcla-drb1" janyuvu dwara encode cheyabadina protein. drb1 anedi hcla-dr yokka atyanta prabalamaina beata upabhaagaanni encode chestundi. drb1 yugmavikalpalu, mukhyamgaa 11 mariyu 13 sthaanaalalo amaino aamlam kramam maarpulanu encoding chesevi, rheumatoid arthuritis pramaadaaniki sambandhinchinavi. 
function.
eee janyuvu dwara encode cheyabadina protein hcla class II beata chain paeralaaglaku chendinadi. rendava taragati anuvu anedi alfa (dra) mariyu beata chain (drb) thoo kuudina heterodymer, rendoo poralo langaru vaeyabadataayi. idhi bahya kana proteinla nundi tii sahayaka kanaalaku utpannamaina peptidelanu pradarsinchadam dwara roganirodhaka vyavasthalo pradhana paatra poeshistumdi. class II anuvulu vruttiparamaina antigen-andinche kanaalalo (apc: b lymphocytes, dendritic kanaalu, macrophaselu) rajyangabaddhamga vyakteekarinchabadataayi mariyu vruttiparamaina kaani apcs loe prerepinchabadataayi.
idhi covid-19 vyaadhi teevrata taggadamtho mudipadi undani aadharalu unnaayi.
janyu nirmaanam mariyu polymorphisms.
beata golusu sumaruga 26-28 kda. idhi 6 exanla dwara encode cheyabadutundi, exon okati leader peptidenu encode chestundi, exanlu 2 mariyu 3 rendu extracellular domainlanu encode chestaayi, exon 4 transmembrane domaine encode chestundi mariyu exon 5 cytoplasmic thokanu encode chestundi. daa anuvu lopala beata golusu peptide binding pratyaekatalanu perkone anni polymorphismlanu kaligi untundi. vandalaadi drb1 yugmavikalpalu vivarinchabaddaayi mariyu eee bahuruupatalaku type cheyadam anedi emuka majja mariyu moothrapindaala marpidi kosam mamuluga jarugutundi.
janyu vyakteekarana.
drb1 daani samaantaraalaina drb3, drb4 mariyu drb5 kante aidu retlu ekkuva sthaayilo vyakteekarinchabadutundi. drb1 anedi anni vyaktulalo untundi. drb1 yokka allelic vaividhyaalu drb3, drb4 mariyu drb5 janyuvulalo dhenithonuu ledhaa okadaanitoe mudipadi undavu. 5 sambandhita sudogenlu unnaih drb2, drb6, drb7, drb8 mariyu drb9. 
anty-iglan 5 vyaadhi unnavaarilo hcla-drb1 * 10:01 yugmavikalpam yokka praabalyam baga perigindi.

