
xrcc2

DNA repair protein xrCC2 anedi maanavulalo "xrCC2" janyuvu dwara encode cheyabadina protein.
function.
eee janyuvu chromosome sthirathvaanni nirvahinchadaaniki mariyu DNA nashtanni saricheyadaaniki homolagus recombinationlo palgone rica/raad 51-sambandhita protein kutumbaaniki chendina sabhyudini encode chestundi. eee janyuvu homolagus recombination dwara DNA double-strand viraamaala marammattulo paalgontundi mariyu idhi chainees chitteluka IRS1 nuu panichestundi, idhi marammatu lopam kaligina utparivartana, idhi aneka vibhina DNA-debbatise agentlaku adhika sunnitatvaanni pradarsistundi.
raad51బii (raad51ell1), raad51సii (raad51ell2), raad51డii (raad51ell3), xrCC2 mariyu xrCC3thoo sahaa raad51 yokka aidu maanava samaantaraalalo xrCC2 protein okati. avi prati okkati raad51 mariyu okadaanitoe okati 25 saatam amaino aamlam shreni gurtimpunu panchukuntaayi.
samaroopa punassamyojanam dwara samarthavanthamaina dna double-strand break marammattuku raad 51 paraalaaglu avasaram mariyu edainaa paralog yokka ksheenata phalitamgaa samaroopa punassamyojana pounahpunyamlo gananeeyamaina taggudala untundi.
xrcsc2 moodu sambandhita samaantaraalatoe naalugu bhagala sanklishtatanu erparustundihi bcdx2 (rad51b-rad51c-rad51d-xrcsc2), rendu samaantaraalu rendava sanklishtamaina cx3 (rad51c-xrcsc3) nuu yerparustaayi. eee rendu samudaayaalu homologus recombinational dna marammattu yokka rendu ververu dasalalo panicheestaayi. bcdx2 complexes raad51 niyamakam ledhaa nashtam jarigina pradaesaalaloo sthireekaranaku baadhyata vahistundi. bcdx2 complexes raad51 nucleoprotein filament yokka assembly ledhaa sthirathvaanni sulabhataram cheyadam dwara panichestundi.
cx3 complexes debbatinna pradaesaalaku raad51 niyaamakaaniki diguvaku panichestundi. cx3 complexes holiday junction resulves kaaryakalaapaalato anubandhinchabadindani choopabadindi, bahusha janyu marpidi maargaalanu sthireekarinche paatralo.
paraspara charyalu.
xrcsc2 anedi raad51l3, bloom syndrome protein mariyu raad51c thoo sankarshana chendutundani choopabadindi.
cancerlo epigenetic lopam.
XrCC2 lopaniki rendu telisina epigenetic kaaranaalu unnaayi, ivi cancer pramaadaanni penchutaayi. ivi "xrcsc2" prothsaahaka yokka methylation mariyu ez2 protein yokka athi-vyakteekarana dwara "xrcsc2" yokka epigenetic anachiveta.
garbhasaya cancer 54 kesulalo 52 kesulalo "xrc2" janyuvu prothsaahaka praantamloo hypermethylatedga unnatlu kanugonabadindi. prothsaahaka hypermethylation janyu vyakteekarananu taggistundi, tadwara "xrcs2" dwara maddatu ivvakapothe, homologus recombinational repairnu anachivese kanitini taggistundi.
ezz2 yokka perigina vyakteekarana xrc2 thoo sahaa raad51 paralagla epigenetic anachivetaku daariteestundi, tadwara homologus recombinational marammattunu taggistundi. eee taggimpu rommu cancerku kaaranamani pratipaadinchabadindi. ezz2 anedi palikomb repressor complexes 2 (prc2) yokka utpreraka upa vibhagam, idhi lysine 27 (hetch3keey27mea) vadda histone hetch3 yokka methylation utprerakam chestundi mariyu sthaanika chromatin punarvyavastheekarana dwara lakshya janyuvula janyu nissabdaanni madhyavartitvam chestundi. aneka cancerlalo eej2 protein niyantrinchabadutundi. rommu cancerlo sagatuna, eej2 mrna niyantrinchabadutundi, mariyu 40 saatam nundi 75 saatam rommu cancerlalo atigaa vyakteekarinchabadina eej2 protein untundi.

