
grahakam

recepterome anedi janyuvu mariyu proteomku oka bhavana analog, conny protesome mariyu connectome vanti itara nirmaanaatmaka ledhaa kriyaatmaka unitlaku kooda.
janyuvutho saaruupyataloo, janyuvu mottam janyuvula samiti, grahakanni grahakaalu ledhaa grahaka anuvulaku daariteese mottam janyuvula samitigaa pariganinchavacchu. dheenini oka nirdishta jeevilo grahaka proteinla mottam sankhyagaa kooda chudavachu.
maanava janyuvulo maanava grahakam kaneesam 5 saatam untundi. idhi bahya mariyu antarjanita ligandlaku saareeraka, rogalakshana mariyu chikitsa pratispandanalanu madhyavartitvam chese grahakalanu encode chestundi.
grahakanni samarthavantamgaa tavvadaaniki siliko (chippai) mariyu bhouthika pareeksha paddhatulalo anekam roopondinchabaddaayi mariyu prabhavam mariyu paraspara charyanu adhyayanam cheyadaaniki bhaarii graahakaala vaipu "saamuuhika-pareeksha" padaarthaalu roopondinchabaddaayi.
aacharanalo, receptorome ippudu saampradaaya grahakalanu matrame kakunda, sambhaavya aushadha lakshyaluga unna maanava janyuvulooni ayan chaanallu mariyu ravaanaadaarulanu kooda kaligi unnatlu pariganinchabadutundi. aneka aushadhaala lakshyamaina zii protein-coupled receptors (gpcr) atyanta prasiddha rakalu.
graahakaalaku ligandla kosam anveshanhalo atyanta churukaina praantaalalo okati, medadu graahakaala rangamlo undhi. psychopharmacologicalga kriyaaseela padaardhaala vaetaloe, psychoactive mokkala utpattulu grahaka shreni vaipu pareekshinchabadataayi. kotta padaarthaalanu kanugonadamtho paatu, eee padaarthaala charyalaku kaaranamayye paramaanu yantraamgaalanu kanugonadam maanava spruha yokka paramaanu aadhaaraalapai antardrushtulanu istundi.
gpcr-receptoromenu pareekshinchadampai oka vyaasamh "receptoromenu maining cheyadam".

