
plasma pora nirmaanam yokka kanchelu mariyu picketla namuunaa

plasma pora yokka kanchelu mariyu picketla namuunaa anedi kana pora nirmaanam yokka bhavana, idhi dravam plasma pora actin aadhaarita compartmentalise cheyabadindani suuchistumdi.
pora-asthipanjaram "kanchelu" mariyu langaru vesina transmembrane protein "piketlu". eee namuunaa gayakudu-nicholson dravam mosaic namuunaa mariyu salman-delbruck dvi-miteeya nirantara dravam namuunaa vanti paatha kana pora nirmaana bhavanala nundi bhinnamgaa untundi, ivi poranu ekkuva ledhaa takkuva sajaateeyamgaa chustayi. single molecule tracking techniclalo iteevali purogatula kaaranamgaa chesina molecular traaphik pariseelanalanu vivarinchadaaniki kanchelu mariyu picketla namuunaanu pratipaadinchaaru.
pora asthipanjara kanche namuunaa.
actin aadhaarita pora asthipanjaram (msc) mesh work neerugaa plasma pora yokka cytoplasmic uparitalampai untundi. pora asthipanjara kanche ledhaa pora asthipanjara coraling modal, eee meshwork pora anuvula parshwa vyaaptiki sambandhinchi plasma poranu aneka chinna compartmentluga vibhajinche avakaasam undani suuchistumdi. cytoplasmic domainlu actin-aadhaarita pora asthipanjaramtho dheekontaayi, idhi pora asthipanjaram meshlo transmembrane (tm) proteinlanu tatkalikamga nirbandhinchadam ledhaa coralingnu prerepistundi. mesh work mariyu membrane madhya dhooram taginantagaa marinappudu ledhaa mesh work tatkalikamga mariyu sthaanikamgaa vidipoyinappudu tm proteins prakkane unna compartmentla madhya dookagalavu. plasma pora lopali uparitalampai unna cytoplasmic anuvulu kooda actin aadhaarita compartmentlalo nirbandhaanni pradarsistaayi.
langaru vesina transmembrane protein picket modal.
pora yokka bayati karapatramlo unna phospholipidla kadalikanu kooda actin-aadhaarita pora asthipanjara mesh work dwara niyantristaaru. idhi aascharyakaramainadi, endukante pora asthipanjaram plasma pora yokka cytoplasmic uparitalampai undhi, mariyu plasma pora yokka bayati karapatramlo unna phospholipidlatho neerugaa sankarshana chendadu.
phospholipids yokka haap vyaaptini vivarinchadaaniki, tm proteinlatho sthiramgaa, "anker tm-protein picket modal" anae modal pratipaadinchabadindi. eee namoonaalo vividha tm proteins pora asthipanjaram venta langaru veyabadi, samalekhanam cheyabadataayi mariyu phospholipids yokka uchita vyaaptiki vyatiraekamgaa picketla varusalagaa samarthavantamgaa panicheestaayi. idhi eee picket proteinla steric addanki prabhavam valla matrame kakunda, chuttupakkala lipid anuvulapai eee sthiramaina tm protein picketla yokka hydrodynamic-friction vanti prabhaavaala valla kooda sambhavistundi.
oka tm protein pora asthipanjaraaniki langaru vesi, sthireekarinchabadinappudu, sthireekarinchina protein uparitalampai hydrodynamic gharshana prabhaavaala kaaranamgaa daani chuttoo unna dravam yokka snigdhata ekkuvagaa untundi. anduvalla, pora-asthipanjara kanche venta amarchabadina ituvanti aneka langaru vesina tm proteins unnappudu, pora anuvulu gundaa velladaaniki compartment sarihaddu kashtamavutundi.
aneka signal transduction margalalo grahaka puna ist pampinhee mariyu clustering keelaka dasalu. pora anuvula punahpampinii/samuuhaanni nirodhinchadamlo ledhaa praarambhinchadamlo cytoskeleton pooshinchina kriyaaseela paatralanu aneka nivedikalu suuchimchaayi.
grahaka monomerlu antar-compartment sarihaddulanu chaalaa sulabhamgaa daatagalavu, conny avi oligomarlanu yerparachinappudu, vaati parimaanam perugutundi mariyu tatphalitamgaa vaati haap raetu natakeeyamgaa taggutundi. 
aneka grahakaalu mariyu itara pora-sambandhita anuvulu actin tantuvulapai tatkalikamga sthireekarinchabadathaayi. eee sthireekarana tarachugaa grahaka nischitaartham meeda meruguparachabadutundi mariyu diguva sanketha anuvunu niyaminchadaaniki oka keelaka dasha. intalo, nimagnamaina grahaka samuuhaala nirmaanam grahaka samuuhamloo actin tantuvula dii novo polymerisationku daariteeyavachchu. anduvalla, actin-aadhaarita pora asthipanjaram grahakam mariyu actin-bound diguva anuvula madhya paraspara charyalanu penchadaaniki mariyu sthaanikeekarinchina sanketam kosam bays paranjaga panicheyavacchu.
pora asthipanjaram mariyu langaru vesina transmembrane proteinlatho tayaaru chesina "piketlu" mariyu "kanchelu" poralo signal transduction yokka praadaesika samacharanni samrakshinchadaaniki kanaaniki oka yantraamgaanni andistaayi, ekkadainaa piketlu lipidlu mariyu transmembrane proteinlanu prabhaavitam chestaayi.
piketlu lipidlu mariyu transmembrane proteinla traaphik rendintinee prabhaavitam chestaayi, ayithe kanchelu ekkuvagaa transmembrane proteinlanu matrame prabhaavitam chestaayi. anduvalla, transmembrane proteins kanchelu mariyu piketlu rendinti dwara kalisi untaayi. rendu namoonaalalo, pora proteins mariyu lipidlu oka compartment nundi prakkane unnadaaniki dookutaayi, bahusha pora mariyu pora asthipanjaram yokka ushna hecchutaggulu vaati madhya samagra pora proteinla prayaanaanni anumatinchenta pedda khaaliini srushtinchinappudu, actin filament tatkalikamga viriginapudu, mariyu/ledhaa pora anuvulu sarihaddu praantamloo unnappudu addankini daatadaaniki taginanta gathi saktini kaligi unnappudu.

