
basimglurant

basimglurant (inn) (developmental code paerlu rg-7090, ro-4917523) anedi mglu5 receptor yokka negative alosteric modulator, idhi chikitsa-nirodhaka maandyam (anubandhamgaa) mariyu pelusugaa unde x syndrome chikitsa kosam roche mariyu chugay pharmaceutical dwara abhivruddhi cheyabadutondi. november 2016 natiki, eee rendu suuchanala kosam idhi rendava dasha clinical trials cheyinchukundi.
maanava mglu5a (jeshke mariyu itarulu) thoo CA21 sameekarana pareeksha aadhaaramgaa oka chinna paramaanu baruvu sammelanam library adhika-nirgamaamsa tera phalitaala nundi praarambhinchi roche vadda nirvahinchina aushadha rasayana shaastra prayatnamlo idhi kanugonabadindi.2015). adhika-nirgamaamsa tera emm. pii. ii. pii, emm. tii. ii. pii mariyu phenobaum vanti aneka emm. zii. ell. yuu. 5 pratyarthulanu gurtinchindi. chugay pharmaceutical bhaagaswaamyamto, basimglurant prastutam november 2016 natiki munupati aushadha pareekshala nundi inca savaranalo undhi.
aushadha shaastram.
charya yokka yantraangam.
preclinical research trials prakaram, basimglurant glutamate receptor emm. zii. ell. yuu. 5kii adhika pratyaekatanu kaligi undani, eee pratyekata paryavasanamga, adhika sthaayi bhadratanu kooda kaligi undani kanugonnaru.
pharmacokinetics.
preclinical drugg trials prakaram, basimglurant elukalalo 7 gantalu mariyu kotulalo 20 gantala tudi ardha-jeevitaanni kaligi undhi, idhi saadhyamayye maanava rogulalo rojuku okasari motaadu niyamaavalini suuchistumdi. elukalu mariyu kothulatho chesina parisoedhanaloo 50 saatam jeeva labhyata undani velladaindi, adanapu adhyayanalu basimglurant 98 nundi 99 saatam plasma protein binding retunu kaligi undani chuupistunnaayi.
clinical trials.
basimglurant kosam modati dasha clinical trials april 2015loe praarambhamai, september 2015loe puurtayyaayi. 4 aarogyakaramaina samuuhaalu, oka pradhana nispruha rugmata samuuhamu mariyu oka placebo samuuhamu madhya 56 mandhi vyaapinchaaru. sambhaavya aushadhamgaa basimglurant yokka bhadratanu adhyayanam cheyadaaniki (mariyu dhruveekarinchadaaniki) eee vichaarananu chepattaru. eee vichaarana puurtayina taruvaata basimglurant rendava dasha aushadha pareekshalanu praarambhinchadaaniki veelu kalpinchindi.
rendava dasha clinical trials chepattabaddaayi, mariyu mottam meeda samarthatha lekapovadam kanugonabadindi. 1.5 mii. graa motaadu unnappatikee merugaina dviteeya mugimpu binduvulu aushadham yokka bhavishyat clinical trialsnu prerepinchaayi.
bhavishyattu.
basimglurant adhika jeeva labhyata, konni bhadrata baadhyatalu mariyu dasha iib trial yokka dviteeya mugimpu binduvulalo vaagdaanam unna aushadham yokka kaavalasina lakshanaalanu choopinchindi. basimglurant bahusha bhavishyattulo punaraavruttulaku lonavutundi mariyu ippativaraku daanini abhivruddhi cheyadaaniki ippatike aushadhamloki pedda pettubadi pettadam valla mallee aushadha pareekshalalo uttiirnata saadhinchadaaniki prayatnistundi.
charitra.
basimglurant modata pelusugaa unde ex syndrome chikitsa kosam abhivruddhi cheyabadindi, conny rendava dasha clinical trials viphalamaina taruvaata roche eee application rangamlo aushadhaanni vidichipetti, depression chikitsalo bhaagamgaa basimglurentnu punaruddharistondi.