
methedrone

methedrone ("paaraa"-methoximethcathinone, 4-methoximethcathinone, bii. keey-pii. emm. emm. eah, pii. emm. sii, methoxifedrine, 4-meemk) anedi cathinon rasayana taragatiki chendina oka vinoda aushadham. rasaayanikamgaa, methedrone "paaraa"-methoximethamphatomine (pmm), methylone mariyu mephedronelatho daggari sambandham kaligi untundi. 2009loe iddaru swedish yuvakula maranam taruvaata methedrone media drushtini aakarshinchindi. rendu sandarbhaallo toxicology vislaeshanhaloo adhika motaadu mariyu tadupari maranaala samayamlo purushulalo methedrone matrame unna ekaika aushadham anie telindi.
aavishkarana.
methedrone samslaeshanha modatisaarigaa 1933loe nivedinchabadindi.
nirmaanam mariyu praticharya.
nirmaanam.
methedrone anedi synthetic cathinone. idhi muula sammelanam kaathinoonku sambandhinchinadi. methedrone anedi sii6hetch5 anuvula chakriya samuuham undatam valla phenethylamine kutumbaaniki chendinadi, dheenilo aaru carbonlu aidu hydrogenlatho shatkona valayanni yerparustaayi, prati okkati carbontho bandhistundi mariyu migilina carbon oka anuvutho ledhaa hydrogen kakunda itara anuvula samuuhamtoe bandhinchabadutundi.
pratispandana.
methedrone yokka reactivity gurinchi etuvanti kathanaalu kanugonabadaledu.
samslaeshanha.
methedrone samslaeshanha chitram 1loe vivarinchabadindi. mariyu eee krindi dasalugaa vraayavacchu.
methedrone kante oka takkuva eethar samuuhamtoe nirmanatmakamga saaruupya sammelanam ayina mephedrone samslaeshanha baga namodu cheyabadindi.
labhyata.
airopalo (sweeden minaha) mariyu americaloni chaalaa rashtraallo internetlo methedrone chattabaddhamgaa konugolu cheyavachu, conny idhi pradhana dukaanaalu mariyu itara retailarlalo kooda chudavachu. idhi, itara kotta ledhaa aniyantrita synthetic mandulu mariyu parisoedhanaa rasaayanaalato paatu, saadhaaranamgaa "baath salt" gaa label cheyabadutundi.
paripalana.
methedrone oka parisoedhanaa rasayanamu mariyu daani ullaasabharitamaina mariyu uddeepana lakshanaalanu durviniyogam cheyavachu. mdma maadirigaane dheenini insoflation, injection, smoking, mala mariyu intravenous maargaala dwara nirvahinchavacchu; ayithe, idhi vyavadhi mariyu vishapuuritam rendintiloonuu chaalaa bhinnamgaa untundi mariyu designer aushadhaalalo saadhaarana vaidya saahityam andubaatulo lenanduna upayoginchinappudu chaalaa jaagratta teesukoovaali.
charya yokka yantraangam.
methedrone oka saktivantamaina serotonin transporter (sert) mariyu norpinefrine transporter (nett) inhibitorga kanugonabadindi, conny balaheenamaina dopamine transporter (dott) inhibitor. vaidyaparamgaa, methedrone yokka dott/sert nishpatti okati kante takkuvagaa untundi. itara analog sammelanaalu saadhaaranamgaa sagam kante takkuva dott/sert nishpattini kaligi untaayi, antey itara mdma-lanty sammelanaala maadirigaa kakunda methedrone sert kante nett mariyu dott nirodhaanni ishtapadadu. daani vidudalaku moggu chuupinappatikii nirodham lekapovadam praanaantaka adrenergic tuphaanuku daariteestundi. sert kosam methedrone yokka adhika empika anedi nirmanatmakamga saaruupya sammelanaalato polchinappudu atyadhika empikalo okatigaa unchutundi.
monoamainlatho mundhe load cheyabadina kanaala nundi neey, daa mariyu 5-hetch tii yokka ravana madhyavartitva vidudalanu methedrone prerepistundi, idhi serotonin-norpinefrine-dopamine (ess. dii. aarr) vidudala agentga maarutundi, dheenini triple vidudala agent (tra) anie kooda pilustaaru, idhi durviniyoga mandulalo saadhaarana lakshanam.
monoamine transporter paraspara charyala paramgaa methedrone mdma maadirigaane untundani kanugonabadindi, ayithe aushadham yokka inn vivo adhyayanam phalitamgaa saadhaaranamgaa mdma adhyayanaalalo nivedinchina daanikante balamaina hyperthermic praticharyaku daariteesindi. serotonin transporter, sert paie methedrone yokka prabhavalu, selective serotonin reaptake inhibitors (ssri) vanti serotonin marpidi mandulatho saha-nirvahana chese vyaktulalo jokyam chesukuni samasyalanu kaliginchavacchu.
jeevakriya.
jeeva vyavasthalo methedrone (4-meemk) elaa panichestundo pariseelinchadaaniki, jaleeya draavanamloo sthirathvaanni adhyayanam cheyadam avasaram. endukante, raktam ledhaa moothramlo neerugaa pareekshinchinappudu, jeeva draavanaalaloo labhinche enjaimla dwara sammelanam ksheenistundaa ledhaa Ph ledhaa karigina oxygen vanti rasayana vidhaanaalaku kaaranamavutundo teliyadu. sammelanam yokka ardha-jeevitakaalam yokka podavu pariseelinchabadindi mariyu vividha phcs unna bufferlalo 12 gantala tarvaata migilina saatam. pareekshinchina phcs 4,7,10 mariyu 12.
chaalaa saaruupya padaarthaala maadirigaane, methedrone kooda aamla draavanaalaloo sthiramgaa untundani nirdhaaranalu unnaayi. ayithe, tatastha mariyu praathamika draavanaalaloo idhi kullipotundi, ikkada draavanam marinta praathamikamgaa marinappudu balamaina kullipovadam jarugutundi.
methedrone daani analogsto polchinappudu, vaati sthirathvaanni prabhaavitam chese aneka amsaalu unnayani kanugonabadindih
methedrone mariyu naalugu itara analogues vaati samuuhaalanu meta-ledhaa paaraa-sthaanaalalo pratyamnaayamgaa kaligi untaayi. eee sammelanaala kosam raetu sthiraamkam, k, nirnayinchabadindi mariyu saahityam nundi teesukunna vaati sutthi sthiraamkaalaku vyatiraekamgaa 12 yokka pH loe kullina raetu sthiraamkaanni (0.693/half-life) plaat cheyadam dwara sutthi plaatunu nirminchaaru. praathamika draavanamloo kooda methedrone saapekshamgaa sthiramaina sammelanam anie idhi mallii choopistundi.
saahityam nundi vacchina phalitaala aadhaaramgaa maroka mugimpu emitante, retunu nirnayinche dasalo parivartana sthithilo pratikuula charge erpadutundi. eee tarkam manchi sarala sahasambandham (r = 0.9805) mariyu saanukuula vaalu (1.76 gaa nirnayinchabadutundi) paie aadharapadi untundi.
methedroneku prasiddhi chendina rendu sambhaavya gvakriyalu unnaih
motaadu mariyu dushprabhaavaalu.
motaadu.
methedrone motaadu elaa ivvabadutundane daani gurinchi chaalaa takkuva samacharam andubaatulo undhi. viniyogadaarula abhiprayam prakaram, methedrone yokka oke motaadu 50 nundi 500 mg varaku untundi, dheeni prabhavalu 45 nimishala nundi rendu gantala varaku untaayi. methedrontho praanaantakamaina matthu gurinchi kaneesam rendu kesulu unnaayi. modati sandarbhamlo, roogi yokka postmartem toda rakta namoonaalo 8.4 micrograamulu/graa methedrone gaadata undhi, roogi teesukunna 16 gantala tarvaata maraninchaadu (polysubstense vadakam kanugonabadindi). rendava sareeramlo toda rakta namoonaalo saandrata 9.6 micrograamulu/graa, methedrone matrame vishapuurita sammelanam. eee kesula shaastreeya parisoedhana eee maranaalaku methedrone matrame kaaranamani mariyu toda raktamlooni saandratalu methedrone yokka praanaantaka sthaayilanu suuchistaayani suuchistumdi. amphetamine vanti itara akrama aushadhaalato poliste chikitsa suuchika (ledhaa bhadrata nishpatti) takkuvagaa undani eee adhyayanalu chuupistunnaayi. adhyayanala prakaram praanaantaka motaadu sumaru 8 microgram/graamu untundi, ayithe viniyogadaarulalo motaadu 0.1 nundi 4.8 microgram/graamu raktam varaku untundi.
dushprabhaavaalu.
methedrone vanti "baath lavanaalu" maanava upayogam yokka vruttaanta mariyu cases nivedikalu, eee padaarthaalu saktivantamaina manasika prabhavalanu utpatti chestayani suuchistunnaayi. eee manasika prabhavalalo manasika pravartana, manasika bhranti, bhramalu, bhraantulu mariyu sweeya gaayam kooda unnaayi.
maanavulalo methedrone yokka bhouthika prabhaavaala gurinchi chaalaa takkuva telusu, conny jantuvulalo methedrone yokka prabhavalapai konni adhyayanalu jarigaayi, kabatti memu elukalalo prabhavalapai drushti pettamu.
elukalalo methedrone prabhavalapai adhyayanalu methedrone circling, beam breaks mariyu hyperactivitylo gananeeyamaina perugudalanu utpatti chestundani chuupistunnaayi. inca, elukalu lalajalam, thala netha mariyu uddeepanalo kooda gananeeyamaina perugudalanu choopinchaayi. methedrone prastutam aneka adhikara paridhulalo chattaparamaina aushadham, ayithe adhyayanalu idhi mephdrone mariyu methylone vanti nishedhinchabadina aushadhaalato pradhana aushadha lakshanaalanu panchukuntundani chuupistunnaayi. alaage, methedrone yokka prabhavalu elukalalo nishedhita aushadhaala prabhaavaalato chaalaa pooli untaayi. saadhaaranamgaa kanipinche akrama aushadhaala maadirigaane methedrone kooda hanikaram kaavacchu anie idhi suuchistumdi.
vishapuuritam.
teevramaina vishapuuritam.
methedrone vishapuuritam gurinchi chaalaa takkuva parisoedhanalu unnaayi. elukalapai jantuvulanu pareekshinchadam dwara okasari parisoedhana jarigindi. alaage, rendu swedish methedrone-baadhitulaloo kanipinche praanaantaka motaadulanu idhe paristhitulalo maranistunna maroe iddaru magavaari raktamlo methedrone saandratalatoe poolchaaru.
maraninchina iddari raktamlo methedrone saandratala sagatu 1.3 micrograamulu/graa raktam. eee baadhitulaloo okariki raktamlo methedrone yokka adhika saandrata, sumaru 4.8 micrograamulu/graa raktam undhi. maraninchina baadhitula raktamlo kanipinche saandratala sagatu 8.0 micrograamulu/graa raktam. praanaantaka motaadulu ledhaa praanaantaka motaadulu aevee teliyavu, idhi methedrone yokka praanaantaka mariyu praanaantaka motaadu madhya bhadrata antaram bahusha chaalaa takkuvagaa untundani suuchistumdi, anduvalla eee aushadhaanni upayoginchadam pramaadakaram endukante vishaprayogaalu mariyu adhe samayamlo maranam pramaadavasaattu sambhavistaayi.
baath salts' loe synthetic cathiones prabhaavaala adhyayanamlo elukalapai methedrone prabhavalanu pareekshinchaaru, eee prabhavalanu kokain mariyu methamphetamine prabhaavaalato poolchaaru. motaru samanvayam, samatulyata mariyu mottam pravartanaa prabhavalapai antardrushtini pondadaaniki vividha pareekshalu nirvahinchabaddaayi. elukalu motaru samanvayam ledhaa samatulyatalo etuvanti vyatyaasaanni choopinchaledu (10 mii. graa./kilolu mariyu 30 mii. graa./kilolu ivvabadina motaadulu). ayithe mottam pravartanaa prabhavalalo gananeeyamaina maarpulu chuupabaddaayi. methedrone paripalana dheeniki daariteesindihi
eee prabhavalu vyasanam sambhaavyatatoo sambandham kaligi untaayi. adhika lalajalam anedi saadhaaranamgaa maanavulalo nivedinchabadina prabhavam kaadu. pradhanamgaa swayampratipatti pratispandanalanu niyantrinche medadu vyavasthala dwara methedrone lalajalam penchutundani soochinchabadindi.
mephedrone, methylenedioxypirovelorove (endipivi) mariyu 4-fluoromethcathinone (4-fmc) thoo poliste, methedrone saapekshamgaa nemmadigaa praarambhamavutundi. tadwara pramaadaanni penchutundi; prabhavalu ventane choopabadananduna, idhi pramaadavasaattu adhika motaaduku daariteeyavachchu. idhi aushadhaanni takkuva prajaadarana kaliginchavacchu, endukante maanavulu locomotor karyakalapalalo pedda, vegavantamaina prarambha perugudalaku kaaranamayye aushadhaalanu ishtapadataaru.
deerghakaalika vishapuuritam.
teevramaina vishapuuritatvamtoe polchinappudu kooda, deerghakaalika vishapuuritatvam gurinchi sarigga parisodhinchabadaledu. kevalam postmortem adhyayanam matrame eee amsampai takkuva parisoedhana chesindi. eee adhyayanam yokka phalitaalu maraninchina baadhitula juttulo methedrone undani matrame choopinchaayi, ayithe, eee phalitaalaku sambandhinchi etuvanti nirdhaaranalu teesukoledu.
garbhadhaarana samayamlo ledhaa garbham dalche mundu garbhinii stree pindampai methedrone vadakam yokka prabhavanni yea adhyayanalu pariseelinchaledu, ledhaa cancer janyutatvaanni kooda parisodhinchaledu.
aarogya pramaadaalu.
methedrontho sambandham unna aarogya pramaadaalu chaalaa varaku teliyavu, conny itara kaathinoonula maadirigaane untaayani bhaavistunnaaru. pratikuula aarogya prabhaavaala nivedikala taruvaata prarambha vikretalu methedrone daadaapu ventane ammakam nundi upasamharinchukunnaaru. paaraa"-methoxy samuuhaanni kaligi unna konni amphetamine analogues teevramaina hyperthermia mariyu ekakaala mavoi mariyu monoamine vidudala charya kaaranamgaa maranaaniki kooda kaaranamavutaayi.
adhika motaadu.
2009loe aagneya sweedanlo iddaru yuvakulu maraninchinanduku kaaraname methedrone adhika motaadu. 
kanugonappudu iddaroo coma sthithilo unnaaru. aasupatriki velle maargamlo okaru gundepotuto badhapadaga, marokaru atyavasara vibhaagamlo 16 gantala paatu praanaalatoe bayatapaddaru.
jantuvulapai prabhavam.
elukalu.
elukala mottam pravartanapai methedrone prabhavam chooputundani kanugonabadindi, veetilo ivi unnaih
chattabaddhata.
dheeni ammakam december 9,2009 nundi sweedanlo nishedhinchabadindi.
idhi october 1,2015 nundi chainaalo niyantrita padaardham.