
prothrambin sakalam 1 + 2

prothrambin fragment 1 + 2 (eff1 + 2), prothrambin fragment 1.2 (eff1.2) gaa kooda vraayabadutundi, idhi prothrambin yokka "inn vivo" cheelika dwara utpatti cheyabadina prothrambin yokka polypeptide sakalam (karakam II) prothrambinase enjaim (karakam xa mariyu karakam va yokka sanklishtata) dwara thrombin (karakam iia) loki. idhi prothrambin yokka enn-terminus nundi vidudala cheyabadutundi. f1 + 2 anedi thrombin generationku marker mariyu anduvalla gaddakattadam kriyaaseelata. idhi "inn vivo" thrombin taraaniki uttama markerga pariganinchabadutundi.
rakta pareekshalatoo eff1 + 2 sthaayilanu lekkinchavacchu mariyu hyper mariyu hypocoagulable sthithula nirdhaaranalo mariyu anticogulant therapy paryaveekshanhaloo upayoginchabadutundi. idhi modatlo radeo immunoassetho nirnayinchabadindi, conny ippudu aneka enjaim-linked immunosarbent vislaeshanhalatoe kolustaaru.
f1 + 2 yokka paramaanu baruvu 41 nundi 43 kda varaku untundi. dheeni jeevasambandhamaina ardha-jeevitam 90 nimishalu mariyu idhi erpadina tarvaata konni gantala paatu raktamlo konasaagutundi. eff1 + 2 yokka ardha-jeevitam saapekshamgaa ekkuva, idhi thrombin-antithrombin complexes mariyu fibrinopeptide eah vanti itara markerla kante konasagutunna gaddakattadanni kolavadaniki marinta nammadaginadigaa chestundi. aarogyakaramaina vyaktulalo eff1 + 2 yokka saandratalu 0.40 nundi 1.11 nm varaku untaayi.
vayassutho paatu eff1 + 2 sthaayilu perugutaayi. sirala thromboembolism, protein sii lopam, proteinla lopam, karnika dada, asthira anjina, teevramaina myocardial infraction, teevramaina stroke, atherosclerosis, paridheeya dhamani vyaadhi mariyu dhumapanam chesevaarilo eff1 + 2 sthaayilu periginatlu nivedinchabadindi. anticoagulants eff1 + 2 sthaayilanu taggistaayani kanugonabadindi. garbhadhaarana samayamlo mariyu ethinylestradiol kaligina janana niyantrana maatrala dwara eff1 + 2 sthaayilu perugutaayi. dheeniki viruddhamgaa, avi estetrol-ledhaa estradiol-kaligina janana niyantrana maatralatho peragadam ledhu. ayithe, noti eastrogen aadhaarita rutukramam aagipoyina harmon chikitsato eff1 + 2 sthaayilu periginatlu nivedinchabadindi, ayithe transdermal estradiol aadhaarita rutukramam aagipoyina harmon chikitsa takkuva ledhaa sthiramaina perugudalaku daariteeyadam ledhu.

