
ravana 1

transportin-1 (ledhaa import-beata 2) anedi maanavulalo "tnpo1" janyuvu dwara encode cheyabadina protein.
function.
eee protein anedi nucleus kuu nuclear proteinlanu lakshyamgaa chesukovadaniki nuclear localization sequensto sankarshana chendhe caryopherin. import-bii1 (janyu kpnb1 dwara encode cheyabadina) nuu upayoginche complexes vanti classical caryopherin receptor complexes, alfa sub unit yokka heterodymer, idhi nuclear localization signalnu gurtistundi mariyu beata sub unit nucleoporinla vadda complexenu dock chestundi. ayithe, transportin-1 neerugaa cargo proteinlatho bandhinchagaladu mariyu deenni cheyadaaniki import inn alfa sub unit avasaram undakapovachhu.
transportin-1 itara digumatidaarula maadirigaane anhu ravaanaanu nirvahinchadaaniki adhe pradhana yantraamgaanni upayogistundani bhaavistunnaaru. idhi nucleoporintho bandhinchadam dwara anhu randhra samudaayaaniki docking madhyavartitvam chestundi mariyu taruvaata shakti avasaramayye yantraangam dwara randhram dwara badilee cheyabadutundi. appudu, naduputunna nucleuselo transportin-1kii bandhistundi, idhi cargo nundi vidipotundi, mariyu transportin-1 nucleus nundi gtp jalavisleshana vidudalalu nadiche cytoplasmku tirigi egumati cheyabadutundi. appudu transportin-1 kotta sarukunu kattadaniki uchitam.
adanamgaa, transportin-1 praadhamika siliyamloki protein ravaanaaku sahaayapadatamlo chikkukundi. eee sandarbhamlo transportin-1 yokka paniteeru anhu randhram dwara kendrakamloki proteinlanu mosukelle vidhamgaane untundani bhaavistunnaaru. transportin-1 sarukunu bandhistundi, aapai eee sarukunu silium adugubhaagamlo oka randhram gundaa velladaaniki sahaayapadutundi. runn mariyu nucleoporinlu kooda eee yantraamgamlo chikkukunnayi.
eee janyuvu yokka pratyaamnaaya vibhajana phalitamgaa rendu transcript rakalu ververu proteinlanu encoding chestaayi.
lakshyalu.
transportin 1 (trn1) anedi shaasthreeyam kaani anhu digumati maargamlo bhaagam. rangtipi jalavisleshana cascade traan1 thoo kalipi kanaala kendrakaaloki proteinla empikanu digumati chesukovadaniki panichestundi. eee lakshyalu saadhaaranamgaa m9 nuclear localization signal anie piluvabade paie-motifnu kaligi untaayi. baga vivarinchina udaaharanalalo hchnrnp eah1 unnaayi.
1loe ravana cheyagala cargo proteinla rakamlo rna-binding proteins (hchnrnp yea1 mariyu hchnrnpf vantivi) mariyu ribosomal proteins kooda unnaayi.
clinical praamukhyata.
amyotrophic lateral sclerosis mariyu frantotemporal dementia anae rendu neurodegenerative vyaadhula vyaadhikaarakamlo trn1 chikkukundi.
paraspara charyalu.
transportin 1 eee krindi vaatitho sankarshana chendutundani choopabadindihi