
epsilon kanam

epsilon kanaalu (ε-kanaalu) ilets off langerhans anie piluvabade clomum yokka praantaalalo kanipinche aidu rakaala endocrine kanaalalo okati. epsilon kanaalu akalini prerepinche grelin anae harmone utpatti chestaayi. ivi modata elukalalo kanugonabaddayi. maanavulalo, eee kanaalu anni ilet kanaalalo 1 saatam kante takkuvagaa untaayi. avi neetilo karige sammelanaalaku abhedyatanu anumatinche gatti koodalla dwara anusandhaaninchabadi untaayi.
aavishkarana.
elukalalo pancreatic ailetlanu parisoedhimchae parisoedhakulu abhivruddhi samayamlo saadhaarana elukala pancreatic kanajaalaanni nakout elukalatho poolchaaru. saadhaarana eluka clomum grelin utpatti chese kanaala janabhanu kaligi untundani vaaru kanugonnaru. tadupari daryaaptu jaragadaniki mundu, "nkx2.2" mariyu "poxes4" janyuvulu β-kanaala kana bhedaanni prothsahistaayani bhaavinchaaru, conny avi lenappudu avi badulugaa ε-kanaalanu yerparustaayi. nkx2.2" mariyu "poxes4" janyuvulu rendoo lenappudu, β-kanaalu erpadatamlo viphalamavutaayani mariyu ε-kanaalu bharti cheyabadatayani kanugonna phalitaala dwara idhi taruvaata dhruvikarinchabadindi. mottammeeda, eluka clomum loe grelin utpatti chese ε-kanaala janabha undani, insulin utpatti chese β-kanaala nock avt apaaramaina mottamlo ε-kanaalaku daariteestundani kanugonnaru. kanaalu gundrani ledhaa andaakaara aakaaramlo untaayi mariyu saadhaaranamgaa dveepaala chuttukolatalo untaayi, konnisaarlu cytoplasmic podigimpulatoe untaayi. ε-kanaalu kooda α-kanaalu mariyu β-kanaalu rendintikee saaruupya kana vamsam nundi unnayani pratipaadinchabaddaayi, conny α-kanaalatoe marinta daggari sambandham kaligi unnatlu kanugonabadindi. genopus kappalu, pilli chepalu mariyu gbrafish vanti itara jantuvula clomum loe ε-kanaalu kanugonabaddayi. eee ilet sell parinaamatmakamgaa samrakshinchabadindani idhi suuchistumdi. grelin marnah kosam situ hybridisationlo upayoginchina oka pratyeka adhyayanam, adevidhamgaa ε-kanaalu anae pratyaekamaina, gatamlo gurtinchabadani, ilet sell janabha undani nirdhaarinchindi. grelin-utpatti chese ε-kanaalapai vaari kotta ghnaanam ε-kanaala erpaatunu nirodhinchadaaniki chikitsa chikitsalo sahaayapadutundani parisoedhakulu aasistunnaaru, idhi type II diabetes chikitsalo sahayapade cellular cascadenu nirodhinchagaladu. eee ilet kanaalu pancreatic cancerlo kooda adhyayanam cheyabadutunnayi, ikkada avi gatamlo nissabda kanitulaku gurtulugaa panicheestaayani bhaavistunnaaru.
abhivruddhi samayamlo epsilon kanaalu.
maanava pindam clomum loe, yeka ε-kanaalu aadima exocrine kanajaalamlo chellacheduruga untaayi mariyu garbhadhaarana vaaram 13 tarvaata samuhaluga kalisipovadam praarambhistaayi. garishta grelin sthaayilu garbhadhaarana 14va vaaramlo gamaninchabadataayi. garbhadhaarana vaaram 21 nundi, ε-kanaalu maanavulalo chinna dveepaalanu abhivruddhi cheyadam chuttoo gamaninchabadataayi, ivi chinna dveepaala anchu vadda daadaapu nirantara poranu yerparustaayi. ε-kanaalu eluka pindam clomum loe kendrikrutamai kanipistaayi, konni kadupulo kooda kanipistaayi. elukala clomum loe eee phalitaalu kanugonabaddayi mariyu confocal microscopyni upayoginchi nirdharinchabaddayi, idhi mandapati namuunaala chitraalanu sekarinchagaladu mariyu phokal plain velupala fluorescent praantaalanu minahaayinchagaladu. eee ilet kanaalu abhivruddhi samayamlo grelinku pradhana vanarugaa untaayi. ε-kanaala nundi vidudalayye grelin kanaala perugudala mariyu vistarananu prothsahistundani, adhe samayamlo maanava klomamloni pancreatic beata kanaala apoptosisnu nirodhistundani kanugonabadindi. konni ε-kanaalu ducta kanaalu mariyu ilet puurvagaami kanaala marker ayina cytocheratin 20nii vyaktam chestaayi, eee ilet kanaalu ductal epithelium nundi udbhavinchaayani suuchistunnaayi. eee kanaala abhivruddhi "ngn3" transcription karakam nundi udbhavistundi. utparivartana chendina nkx2.2 janyuvulatho unna elukalu ε-kanaala perugudalanu chuuputaayi. cellular sthaayilo, ε-kanaalu nkx2-2 mariyu isl1 rendintinee saha-utpatti chestaayi, conny gatamlo oohinchinatlugaa nks6-1 mariyu poxes6 kaadu. inca, eee rakamaina kanam aisl1 nuu saha-utpatti chestundi, idhi dorsal pancreatic moggu yokka messenchime abhivruddhilo mariyu dorsal pancreatic epitheliumnu endocrine kanaalugaa vaeru cheyadamlo paatra poeshistumdi. mottam 36 janyuvulu ε-kanaalalo gananeeyamgaa samruddhiga untaayi, ivi proteinage nirodham, harmonela prosessing, kana valasalu mariyu roganirodhaka charyalo sahaayapadataayi, ivi vaatini α-, β-, δ-mariyu pp-kanaala nundi vaeru chestaayi. adanamgaa, ε-kanaala (110 ±3 nm) sravinche vesicals α-kanaala (185 ±7 nm) kante chaalaa chinnaviga untaayi. itara pancreatic ilet kanaala maadirigaa kakunda, ε-kanaalu itara pancreatic harmonelanu (insulin, glucagon, homeostatic) kooda utpatti cheyavu mariyu avi cart peptidenu vyaktam cheyavu. ε-kanaalanu prabhaavitam chese nirdishta janyuvulaku udaaharanalu asail-kmjime, synthetase long chain family member 1 (ACSL1) mariyu defencin beata 1. grelin prosessinglo ACSL1 paatra pooshistundani bhaavistaaru, ayithe defencin beata 1 roganirodhaka saktini niyantrinchadaaniki bacteria, vairaslu mariyu eestnu champagala proteinnu utpatti chestundi. puttina taruvaata, ε-kanaala sankhya taggutundi mariyu yuktavayassulo arudugaa maarutundi. elukalu, edaari jerbil mariyu african manchu elukalapai chesina adhyayanalu eee amsampai daggari sambandhita phalitaalanu icchaayi.
peddalalo epsilon kanaalu.
clomum loe grelin utpatti chese ε-kanaalanu yuktavayassu varaku unchina ekaika jaathi maanavulu. phalitamgaa, eee kana rakanni peddavaarilo adhyayanam cheyadamlo ibbandulu unnaayi, endukante idhi maanava clomum loe matrame gamaninchavacchu. pindam abhivruddhi chendutunna varalalo, ε-kanaalu ilet kanaalalo 10 saatam kaligi untaayi, conny puttina taruvaata, vaati kuurpu vayojana ilet kanaalalo kevalam 1 saataaniki taggutundi. peddavaarilo prati dveepaaniki ε-kanaala sagatu sankhya yokka anchanaalu ververu phalitaalato sankhyalo maarutuu untaayi. vayojana clomum yokka prati dveepamlo sumaru 3 nundi 5 ε-kanaalu unnayani oka adhyayanam kanugondi, indulo mottam 1,000 dveepaalu unnaayi. maroka adhyayanam oka dveepaaniki sagatuna 12 ± 1.2-ε-kanaalanu gamaninchindi. vayojana clomum namoonaalalo, avi gundrani ledhaa andaakaara aakaaramlo unnatlu gamaninchabadataayi mariyu samuuhaalu ledhaa yeka kanaalalo vividha parimaanaalalo dveepaala aavaranapai sthaanikeekarinchabadathaayi. elukalalo, ε-kanaalu abhivruddhi samayamlo pancreatic ilets mariyu kadupulo untaayi, conny puttina tarvaata kadupulo khachitamgaa kanipistaayi. maanavulu mariyu elukalalo, grelin yuktavayassu ledhaa abhivruddhi dasalalo itara harmonlatho saha-sthaanikeekarinchabadindaa ledhaa anae daanipai phalitaalu maarutuu untaayi. vayojana clomum loe ε-kanaala korata kaaranamgaa, avi sareeram antataa prasarana chese pedda mottamlo grelin nuu utpatti cheyavu anie anchanaa veyabadindi. maanava vayojana clomum sumaru 0.13 graamula ε-kana kuurpunu kaligi untundi. lingam mariyu vayassu dveepaalalo ε-kanaala sagatu sankhyanu prabhaavitam cheyavu. ayithe, bmi mariyu ε-kanaala sankhya madhya viloma sambandham gurtinchabadindih shareera baruvu perige koddi, ε-kanaala sankhya taggutundi. bmi peragadam valla eee kanaala nashtam insulin sraavam peragadaaniki daariteestundi, mariyu pancreatic iletslo apoptosis mariyu vaapu vachhe pramaadam perugutundi. vayojana ε-kanaalalo kana pora grahakaalalo short-chained fatty assid receptor ffar3, g protein-coupled bail assid receptor 1 (gpcr), interferon-α mariyu interferon-β receptor subunit 1, interferon-γ receptor 2, immunoglobulin g up take, plasminogen receptor mariyu cd320 receptor yokka niyantranaku prasiddhi chendina grahakam unnaayi. vividha rakaala grahakaalu harmonelu, poeshakaalu, lipidlu mariyu cytokine ligandlanu bandhinchadaaniki anumatistaayi. ε-kanaalalo unde praadhamika cellular jeevakriya maarga karakam kovvu aamlam jeevakriya marganni roopondinche sabhyulu, ACSL1. ACSL1 anedi kovvu aamlam aakseekarana yokka modati dasalo palgone enjaim, mariyu eee maargam eee ilet kanamlo pratyaekamgaa grelin asail maarpunu savarinchadaaniki panichestundi. avasaramaina ε-kana paripakvata mariyu samrakshana ayina transcription karakalu mottam 366 gaa lekkinchabaddaayi. prati okka transcription karakam yokka vidhulu inca adhyayanam cheyabadaledu.