
mitochondrial shuttle

mitochondrial shuttles anevi biochemical ravana vyavasthalu, ivi lopali mitochondrial pora antataa tagginche agentlanu ravana cheyadaaniki upayogistaaru. naad mariyu naad + poranu daatalevu, conny idhi poranu daatagala vyaamoham mariyu [qh2] vanti maroka anuvunu tagginchagaladu, tadwara daani electronlu electron ravana golusuku cherukogalavu.
maanavulalo rendu pradhana vyavasthalu glycerol fasfate shuttle mariyu mallet-aspertate shuttle. malat/eah-ketogluterate antiporter vidhulu electronlanu kadilistaayi, ayithe aspertate/glutamate antiporter amaino samuuhaalanu kadilistundi. idhi mitochondria daani kaaryaacharanaku avasaramaina uparitalaalanu samarthavantamgaa sweekarinchadaaniki veelu kalpistundi.
shottles.
maanavulalo, glycerol fasfate shuttle pradhanamgaa godhuma kovvu kanajaalamlo kanipistundi, endukante marpidi takkuva samarthavantamgaa untundi, tadwara vaedini utpatti chestundi, idhi godhuma kovvu yokka pradhana prayojanaalalo okati. idhi pradhanamgaa pillalalo kanipistundi, ayithe idhi moothrapindaala chuttoo mariyu mana meda venuka bhaagamlo peddavaarilo chinna mottamlo untundi. malat-aspertate shuttle sariiramlooni migilina bhagalalo chaalaa varaku kanipistundi.
shuttles loe oxaloacetate vanti poralo protein transporter laeni metabolitelanu ravana cheyadaaniki upayoginche yantraamgaala vyavastha untundi.
mallet shuttle.
mallet shuttle mitochondrianu metabolitela viniyogam lekunda naad nundi electronlanu taralinchadaaniki anumatistundi mariyu idhi metabolitelanu ravana cheyadaaniki mariyu mitochondrial matricks mariyu cytoplasm lopala samatulyatanu unchadaaniki rendu antiporterlanu upayogistundi.
cytoplasmic vaipu aspertate nundi oka amaino samuuhaanni tolaginchadaaniki oka transominage enjaim upayoginchabadutundi, idhi oxaloacetatega maarchabadutundi, appudu mallet dehydrogenase enjaim oxaloacetate maletga tagginchadaaniki naad cofactornu upayogistundi, idhi transporter undatam valla pora antataa ravana cheyabadutundi.
mallet maatrika lopaliki vacchina tarvaata adhi tirigi oxaloacetatega maarchabadutundi, idhi aspartatega maarchabadutundi mariyu chakram konasaagadaaniki veelugaa mitochondria velupala tirigi ravana cheyavachu. pora antataa oxaloacetate kadalika electronlanu ravana chestundi mariyu dheenini bayati ring anie pilustaaru. antargata valaya praathamika pani electronlanu kadilinchadam kaadu, jeevakriyanu punarutpatti cheyadam.
glycerol fasfate shuttle.
glutamate vadakam dwara oxaloacetate aspartatega marchadam saadhinchabadutundi. glutamate antiporter dwara aspertate thoo ravana cheyabadutundi, tadwara oka aspertate kanaanni vidichipettinappudu, glutamate pravesistundi. maatrikalooni glutamate oka-ketogluteratega maarchabadutundi, idhi maletto antiporterlo ravana cheyabadutundi. cytoplasmic vaipu eah-ketogluterate aspertatenu tirigi oxaloacetatega marchinappudu tirigi glutamatega maarchabadutundi.
cancerku vyatiraekamgaa upayoginchandi.
chaalaa cancer kanaalu vaegamgaa vistarinchadaaniki glucose jeevakriyanu penchadaaniki shareera jeevakriya karyakalapalalo utparivartanaku kaaranamavutaayi. kanaala jeevakriya karyakalapalanu penche mariyu saadhaarana kanaanni kaniti kanamgaa marche utparivartanaalanu oncogenes antaaru. cancer kanaalu aneka itara kanaalaku bhinnamgaa untaayi. vatiki chaalaa takkuva durbalatvaalu unnaayi, conny glucose yokka jeevakriya mandaginchabadatam valla malat-shuttle yokka transmination nirodham vistarananu mandaginchina prayogaalu.

