
silikolo

jeevasaastram mariyu itara prayogaatmaka saastraalalo, computerlo ledhaa computer anukarana dwara silikolo prayogam nirvahistaaru. eee padabandham 'silicon loe' (sarainadi) kosam suudoe-latin, idhi computer chiplalo silikaannu suuchistumdi. idhi 1987loe latin padabandhaalaku suuchanagaa roopondinchabadindi, mariyu, ivi saadhaaranamgaa jeevasaastramlo (mukhyamgaa vyavasthala jeevasaastram) upayoginchabadataayi. taruvaati padabandhaalu varusaga, jeevulalo, bayati jeevulalo chesina prayogaalanu mariyu avi prakrutilo ekkada kanipistayo suuchistaayi.
charitra.
1987loe laas alamos national laboratorylo naan leanier studies centerlo aaa amsampai varkshaapnu prakatinchina christopher langton krutrima jeevitaanni vivarinchadaaniki eee padabandhaanni mottamodata upayoginchaaru. 1989loe nyuu meksikoolooni laas alamoselo jarigina varkshaaplo "cellular automata theory und applications" loe puurtigaa computerlo nirvahinchina jeevasastra prayogaalanu vargeekarinchadaaniki "siliko" anae vyakteekarananu modatisaarigaa upayoginchaaru, national atanamus university off mexico (unam) kii chendina ganita shaastravetta pedro miramonts "dna und rna physicochemical parimitulu, cellular automata und molecular evalution" anae nivedikanu samarpinchaaru. eee rachananu taruvaata miramontes thana vyasamga samarpinchaaru.
"european community commission dwara bacteria janyuparamaina kaaryakramaala srushtiki maddatugaa vraayabadina swetapatraalalo "siliko" upayoginchabadindi. siliko loe" kanipinche modati suuchimchabadina kaagitam 1991loe oka french brundamchae vraayabadindi. "siliko loe" kanipinche modati suuchimchabadina pustaka adhyayam hohns bii. chae vraayabadindi. 1990loe seaberg, shanta phay institute vadda sanklishta vyavasthalapai vesavi paatasaalalo pradarsinchaaru.
siliko loe" anae padabandham vaastavaaniki sahaja ledhaa prayogasaala prakriyalanu (anni sahaja saastraalalo) roopondinche computer anukaranalaku matrame vartistundi mariyu computer saadhaaranamgaa chese gananalanu suuchimchadu.
virtual screening thoo aushadha aavishkarana.
vaidyamlo siliko adhyayanamlo khareedaina prayogasaala pani mariyu clinical trials avasaranni taggistune aavishkarana retunu vegavantam chese saamarthyam undani bhaavistunnaaru. dheenini saadhinchadaaniki oka maargam aushadha abhyardhulanu marinta samarthavantamgaa utpatti cheyadam mariyu pareekshinchadam. udaaharanaku, 2010loe, protein docking algorithm eedaaknu upayoginchi (protein-ligand docking chudandi), parisoedhakulu "silikolo" cancer kaaryakalaapaalaku sambandhinchina enjaimku sambhaavya nirodhakaalanu kanugonnaru. yaabhai saatam anuvulu taruvaata kriyaaseela nirodhakaalu "inn vitro" gaa chuupabaddaayi. eee vidhanam rojuku vaelaadi vibhina sammelanaalanu bhouthikamgaa pareekshinchadaaniki khareedaina adhika-nirgamaamsa pareeksha (hetch. tii. ess) robotic prayogasaalala vaadakaaniki bhinnamgaa untundi, tarachugaa 1 saatam ledhaa anthakante takkuva kramamlo anchanaa vesina hitt retutho, tadupari pareeksha tarvaata nijamaina leedlu inca takkuvagaa untaayani bhaavistunnaaru (aushadha aavishkarana chudandi).
udaaharanaku, covid-19 (saars-cove-2) kuu sambhaavya nivaaranala kosam vetakadaaniki aushadham yokka punahprayojana adhyayanam kosam eee saanketikatanu upayoginchaaru.
sell namuunaalu.
cellular pravartana yokka computer namuunaalanu sthaapinchadaaniki prayatnaalu jarigaayi. udaaharanaku, 2007loe parisoedhakulu aushadha aavishkaranalo sahaayapadataaniki kshayavyadhi yokka oka siliko namuunaanu abhivruddhi chesaaru, idhi nija samayamlo anukarinchina vruddhi raetla kante vaegamgaa undatam valla pradhana prayojanam, aasaktigala drugvishayaanni nelala kante nimishaallo gamaninchadaaniki veelu kalpistundi. calobacter cresentus" yokka perugudala chakram vanti nirdishta cellular prakriyanu roopondinchadampai drushti saarinche marinta panini kanugonavacchu.
eee prayatnaalu oka kanam yokka mottam pravartana yokka khachitamaina, puurtigaa anchanaa vese computer namuunaa kante chaalaa takkuvagaa untaayi. molecular dynamics mariyu sell biology avagaahanalo parimitulu alaage andubaatulo unna computer prosessing power lekapovadam valla silicon sell namoonaalalo unna vaati upayogaanni parimitam chese pedda saralikruta anchanaalu erpadataayi.
janyusaastram.
dna sequencing nundi pondina digital janyu shrenulanu sequence databaselalo nilva cheyavachu, vislaeshimchavachchu (sequence vislaeshanha chudandi), digitalga maarchavacchu ledhaa krutrima janyu samshlaeshanhanu upayoginchi kotta vaastava dnanu roopondinchadaaniki templetlugaa upayoginchavacchu.
itara udaaharanalu.
silikolo computer aadhaarita modeling saanketikatalu kooda eee krindi vaatilo vartimpajeyabaddaayih

