insulin nirodhakata

insulin nirodhakata (ir) anedi oka rogalakshana paristhiti, dheenilo kanaalu insulin harmonku saadhaaranamgaa spandinchadamlo viphalamavutaayi ledhaa hyperinsulinemiaku pratispandanagaa insulin grahakalanu taggistaayi.
insulin anedi raktam nundi kanaalaloki glucosenu ravana cheyadaaniki veelu kalpinche oka harmon, tadwara raktamlo glucose (raktamlo chakkera) nuu taggistundi. aahaaramlo teesukune carbohydratelaku pratispandanagaa clomum insulin vidudala chestundi. insulin nirodhakata unna sthithulalo, adhe mottamlo insulin glucose ravana mariyu raktamlo chakkera sthaayilapai adhe prabhavanni chuupadu. insulin nirodhakataku aneka kaaranaalu unnaayi mariyu antarleena prakriya inca puurtigaa ardham kaaledu. insulin nirodhakataku pramaada karakalu oobakaayam, nischala jeevanasaili, madhumeham yokka kutumba charitra, vividha aarogya paristhitulu mariyu konni mandulu. insulin nirodhakata jeevakriya syndromelo oka bhaagamgaa pariganinchabadutundi. upavaasam insulin sthaayilu ledhaa glucose tolerance pareekshalu vanti insulin nirodhakatanu kolavadaniki aneka margalu unnaayi, conny veetini tarachugaa clinical practicelo upayogincharu. vyayamam mariyu aahaaramlo maarpulu vanti jeevanasaili vidhaanaalatho insulin nirodhakatanu meruguparachavacchu ledhaa tippavacchu.
kaaranam.
pramaada karakalu.
adhika baruvu ledhaa oobakaayam ledhaa nischala jeevanasaili kaligi undatam vanti insulin nirodhakataku aneka pramaada karakalu unnaayi. vividha janyu karakalu pramaadaanni penchutaayi, madhumeham yokka kutumba charitra vantivi, mariyu polycystic ovaree syndrome vanti insulin nirodhakathatho sambandham unna konni nirdishta vaidya paristhitulu unnaayi.
national institute off diabetes und digestive und kidney diseases oka vyakti insulin nirodhakataku gurayye nirdishta pramaadaalu eee krindi vidhamgaa undavacchani perkondih
adanamgaa konni mandulu mariyu itara aarogya paristhitulu pramaadaanni penchutaayi.
jeevanasaili karakalu.
aahara karakalu insulin nirodhakataku dohadam chestaayi, ayithe, poeshakaahaara parisoedhana yokka parimitulanu batti kaarana aaharalanu gurtinchadam kashtam. insulin nirodhakathatho swatantramgaa mudipadi unna aaharalalo adhika glycemic suuchikalatoe chakkera ekkuvagaa, omega-3 mariyu fiber takkuvagaa, mariyu adhika-ruchikaramainavi, ivi atigaa tine pramaadaanni penchutaayi. metabolic syndrome antuvyaadhi venuka kovvu mariyu chakkera adhikamgaa unde aaharaalu mariyu paaneeyaala adhika viniyogam praathamika karakamga pratipaadinchabadindi.
kana porallooni polyunsaturated mariyu santrupta phospholipids nishpattini marchagala saamarthyam kooda aahaaramlo undhi. polyunsaturated kovvu aamlalu (pufas) saatam insulin nirodhakathatho vilomamgaa sambandham kaligi untundi. pufa yekagratanu penchadam dwara kana pora dravatanu penchadam valla insulin graahakaala sankhya peragavacchani, daani graahakaalato insulin yokka anubandham peragavacchani mariyu insulin nirodhakata taggutundani oohinchabadindi.
vitamin dii lopam kooda insulin nirodhakathatho mudipadi undhi.
nischala jeevanasaili insulin nirodhakata abhivruddhi chendhe avakaasaanni penchutundi. epidemiological adhyayanaalalo, adhika sthaayi saareeraka shrama (rojuku 90 nimishala kante ekkuva) madhumeham pramaadaanni 28 saatam taggistundi.
insulin nirodhakata mariyu syrcadian laya madhya sambandham undani adhyayanalu sthiramgaa choopinchaayi, insulin sunnitatvam udayam ekkuvagaa mariyu saayantram takkuvagaa untundi. syrcadian laya mariyu bhojana schedule madhya asamatulyata, syrcadian laya rugmatalalo vantivi, insulin nirodhakatanu penchavacchu.
mandulu.
konni mandulu carticosteroids, protease inhibitors (hechaivi aushadhaala rakam) mariyu asaadhaarana anticycotics vanti insulin nirodhakathatho mudipadi untaayi.
harmonelu.
cartisol, groth harmon mariyu human plaasental lactogenlatho sahaa aneka harmonelu insulin nirodhakatanu prerepinchagalavu.
cartisol insulinnu nirodhistundi mariyu hepatic gluconiogenesis peragadaaniki, glucose yokka paridheeya viniyogam taggadaaniki mariyu insulin nirodhakatanu penchadaaniki daariteestundi. idhi glucose transporterla (mukhyamgaa (mukhyamgaa nuu kana poraku badilee cheyadaanni tagginchadam dwara deenni chestundi.
bariatric shastrachikitsa tarvaata maanavulalo insulin sunnitatvamlo gananeeyamaina merugudala mariyu dudenamnu shastrachikitsa dwara tolaginchina elukala aadhaaramgaa, shareera kanaalu insulin nirodhakatanu kaligi undataaniki soochinche chinna pregu yokka prarambha bhaagam yokka shleshmamlo kontha padaartham utpatti avtundani pratipaadinchabadindi. utpatti chese kanajaalaanni tolaginchinatlayithe, signal aagipotundi mariyu shareera kanaalu saadhaarana insulin sunnitatvaaniki tirigi vastaayi. atuvanti padaardham inca kanugonabadaledu, mariyu atuvanti padaardham uniki oohaajanitamgaa undhi.
leptin anedi obi janyuvu mariyu kovvu kanajaalaala nundi utpatti ayye harmon. aakali nindinappudu sariiraanni apramattam cheyadam dwara akalini niyantrinchadam dheeni saareeraka paatra. leptin lekapovadam teevramaina oobakaayaaniki kaaranamavutundani mariyu insulin nirodhakathatho balamgaa mudipadi undani adhyayanalu chuupistunnaayi.
vyaadhulu.
polycystic ovaree syndrome mariyu naan-alcoholic fatty liver disease (naffled) insulin nirodhakathatho mudipadi untaayi. hepatitis sii valla prajalu type 2 diabetes mariyu insulin nirodhakatanu abhivruddhi chese avakaasam moodu nundi naalugu retlu ekkuva.
mitochondrial panicheyakapovadam.
vividha paddatulatoe kuudina bahula adhyayanalu insulin nirodhakata yokka vyaadhikaarakamlo mitochondria yokka balaheenamaina paniteeru keelaka paatra pooshinchavacchani suuchistunnaayi. pratispandinche praanavaayuvu jaatulu, janyu karakalu, vruddhaapyam mariyu mitochondrial biogenesis taggadam valla mitochondrial panicheyakapovacchu. ayithe, mukhyamaina prasnalu netikee parishkarinchabadaledu. kathinamaina adhyayanala dwara dhruvikarinchabadite, mitochondrial rugmatalu mariyu insulin sunnitatvam taggadam madhya sambandham kotta chikitsa vidhaanaalaku maargam sugamam chestundi.
vaapu.
infectionla vanti teevramaina ledhaa deerghakaalika vaapu, insulin nirodhakataku kaaranamavutundi. tnf-α anedi oka cytokine, idhi lipolysisnu prothsahinchadam dwara, insulin signalingku antaraayam kaliginchadam dwara mariyu mariyu yokka vyakteekarananu tagginchadam dwara insulin nirodhakatanu prothsahistundi.
janyusaastram.
aneka janyu sthaanaalu insulin sunnitatvamto mudipadi unnayani nirdharinchabaddayi. indulo insulin nirodhakathatho sambandham unna unna, gkr mariyu igfi janyuvulaku sameepamlo unna lokilo vaividhyam untundi. janyuvulaku sameepamlo unna lokey insulin nirodhakathatho mudipadi undani tadupari parisoedhanaloo telindi. ayithe, eee lokeelu insulin nirodhakata yokka janyu bhaagamlo 25-44% matrame kaaranamani anchanaa veyabadindi.
pathophysiology.
saadhaarana gvakriyalo, perigina raktamlo glucose raktamloki insulinnu vidudala cheyadaaniki clomum loe unna langerhans dveepaalalooni beata (β) kanaalanu suuchistumdi. insulin sariiramlooni insulin-sensitive kanajalalanu (pradhanamgaa asthipanjara kandara kanaalu, kovvu kanajaalam mariyu kaaleyam) glucosenu grahinchela chestundi, idhi saktini andinchadamtho paatu raktamlo glucosenu taggistundi. raktamlo glucose sthaayi padipovadamtho beata kanaalu insulin utpattini taggistaayi, raktamlo glucose sumaru 5 mmol/ell (90 engy/dl) sthiramgaa sthirapadataaniki veelu kalpistundi. insulin-nirodhaka" vyaktilo, raktamlo glucose sthaayilanu niyantrinchadamlo insulin yokka saadhaarana sthaayilu adhe prabhavanni chuupavu.
insulin nirodhakata paristhitulalo sareeram insulinnu utpatti chesinappudu, kanaalu daanini samarthavantamgaa grahinchalevu ledhaa upayoginchalevu mariyu adhi raktapravaahamlo untundi. kovvu mariyu kandara kanaalu vanti konni kana rakalaku glucosenu grahinchadaaniki insulin avasaram mariyu eee kanaalu insulin prasaranaku taginantagaa spandinchadamlo viphalamainappudu, raktamlo glucose sthaayilu perugutaayi. kaaleyam saadhaaranamgaa insulin samakshamlo daani glucose sraavam tagginchadam dwara glucose sthaayilanu niyantrinchadaaniki sahaayapadutundi. ayithe, insulin nirodhakatalo, kaaleyam yokka glucose utpattilo eee saadhaarana taggimpu sambhavinchakapovachhu, idhi raktamlo glucose perugudalaku marinta dohadam chestundi.
kovvu kanaalalo insulin nirodhakata valana prasarana lipidlu taggutaayi mariyu nilva chesina triglyzaridela jalavisleshana perugutundi. idhi rakta plasmalo perigina uchita kovvu aamlaalaku daariteestundi mariyu insulin nirodhakatanu marinta digajaarchagaladu. kovvu kanaalalo shakti nilva kosam insulin praadhamika harmonela sanketam kabatti, idhi hepatic mariyu asthipanjara kandaraala nirodhakatanu edurkonadamlo vaati sunnitatvaanni nilupukuntundi, insulin nirodhakata kotta kovvu kanajaalam erpadataanni prerepistundi mariyu baruvu perugutanu vegavantam chestundi.
insulin nirodhakata sthithulalo, clomum looni beata kanaalu vaati insulin utpattini penchutaayi. idhi adhika raktamlo glucosenu bharti cheyadaaniki adhika rakta insulin (hyperinsulinemia) kuu kaaranamavutundi. insulin nirodhakata yokka eee bharti dasalo, beata kana paniteeru niyantrinchabadutundi, insulin sthaayilu ekkuvagaa untaayi mariyu raktamlo glucose sthaayilu ippatikee nirvahinchabadataayi. pariharam insulin sraavam viphalamaithe, upavaasam (balaheenamaina upavaasa glucose) ledhaa post praandiyal (balaheenamaina glucose sahanam) glucose saandratalu perugutaayi. chivariki, nirodhakata peragadam mariyu insulin sraavam viphalamavadam valla glucose sthaayilu periginappudu type 2 diabetes sambhavistundi. hyperglycemia paristhitiloo taginanta insulin utpatti cheyalekapovadam anedi insulin nirodhakata nundi type 2 diabetisku parivartananu vargeekaristundi.
insulin nirodhakata anedi insulin-nirodhaka vishayaalalo mariyu type 2 diabetes rogulalo pregula nundi utpannamaina apab-48 utpatti retutho balamgaa mudipadi untundi. insulin nirodhakata tarachugaa viseral kovvu, adhika raktapotu, hyperglycemia mariyu dyslipidemia unnavaarilo kanipistundi, indulo adhika triglyzarides, chinna dattamaina takkuva saandrata kaligina lipoprotein (sdldl) kanaalu mariyu adhika saandrata kaligina lipoprotein (hcdl) collustroll sthaayilu taggutaayi. viseral kovvu kuu sambandhinchi, insulin nirodhakathatho rendu balamaina sambandhaalanu chaalaa aadharalu suuchistunnaayi. modata, subcutaneous kovvu kanajaalam vale kakunda, viseral kovvu kanaalu tumour necrosis phyaaktar-alfa (tnf-eah), mariyu interleukins-1 mariyu-6 modalaina proinflammatory cytokinlanu gananeeyamaina mottamlo utpatti chestaayi. aneka prayogaatmaka namoonaalalo, eee shotha nirodhaka saitokinlu kovvu mariyu kandaraala kanaalalo saadhaarana insulin charyanu debbateestaayi mariyu viseral kovvu unna rogulalo gamaninchina mottam shareera insulin nirodhakataku kaaranamayye pradhana karakamga undavacchu. proinflammatory cytokins utpattipai ekkuva drushti ikk-beata/nf-kappa-bii maargampai kendrikarinchabadindi, idhi insulin nirodhakataku kaaranamayye inflammatory markerlu mariyu madhyavartula transcription penche protein network. rendavadi, viseral kovvu kaaleyamlo kovvu perukupovadaniki sambandhinchinadi, eee paristhitini naan-alcoholic fatty liver disease (naffled) anie pilustaaru. naffled phalitamgaa raktapravaahamloki uchita kovvu aamlalu adhikamgaa vidudala avtayi (perigina lipolysis kaaranamgaa), mariyu glycogen nilvalu hepaticga vichchinnamai glucose (glycogenolysis) gaa maaradam, eee rendoo paridheeya insulin nirodhakatanu teevrataram chese prabhavanni kaligi untaayi mariyu type 2 diabetes mellitus sambhaavyatanu penchutaayi.
nirantara saanukuula shakti samatulyatalo (atigaa tinadam vantidi) sambhavinche kovvu kanajaalam yokka adhika vistarananu insulin nirodhakata mariyu daanitoe paatu vyaadhi sthithulaku kaaranamayye lipotoxic mariyu inflammatory prabhavalanu prerepinchadaaniki vaidal-puig dwara pratipaadinchabadindi.
alaage, insulin nirodhakata tarachugaa hypercogulable sthithi (balaheenamaina fibrinolysis) mariyu perigina inflammatory cytokine sthaayilatho mudipadi untundi. 
paramaanu yantraangam.
paramaanu sthaayilo, oka kanam insulin graahakaala dwara insulinnu grahistundi, signal samishtiga mariyu/eketi/entore signalling maargam anie piluvabade signalling cascade dwara vyaapistundi. iteevali adhyayanalu konni rakaala kanaalaku saareeraka paristhitulalo maargam oka dwaipaakshika marpidiga panichestundani suuchimchaayi, mariyu insulin pratispandana oka pravesha drugvishayam kaavacchu. insulin patla maargam yokka sunnitatvam uchita kovvu aamlaala lipolysis vanti aneka kaarakaala dwara mandaginchavacchu, idhi insulin nirodhakataku kaaranamavutundi. ayithe, vistruta drukpatham nundi, maarutunna vaataavaranam ledhaa jeevakriya paristhitulaku anugunamgaa jeeviki sunnitatva tuning (sunnitatva taggimputoe sahaa) anedi oka saadhaarana paddhati. udaaharanaku, garbham anedi jeevakriya paristhitulalo oka pramukha maarpu, dheeni kinda talli medadulaku (talli medadu mariyu pindam medadu) ekkuva glucosenu migilchadaaniki thana kandaraala insulin sunnitatvaanni tagginchukovali. pratispandana parimitini penchadam dwara dheenini saadhinchavachchu (i.ii.insulin receptor substrate (irs) mariyu mariyu madhya paraspara charyaku aatamkam kaliginchadaaniki plaasental groth factornu sravinchadam dwara, sunnitatvam prarambhanni vaida veyadam), idhi insulin nirodhakata yokka "sardubaatu cheyagala threashold parikalpana" anie pilavabade saaraamsam.
antioxidant rakshana yantraamgaa panichese sell mitochondrialo superoxide dismutase dwara adanapu poeshanhaku pratispandanagaa insulin nirodhakata pratipaadinchabadindi. insulin nirodhakata yokka vividha kaaranaala krinda eee link unnatlu telustondi. mitochondrial ann kaplarlu, electron transport chain inhibitors ledhaa mitochondrial superoxide dismutase mimetics kanaalanu bahirgatam cheyadam dwara insulin nirodhakatanu vaegamgaa tippikottavachani kanugonadam meeda kooda idhi aadharapadi untundi.
rooga nirdhaarana.
upavaasam insulin sthaayilu.
upavaasam seeram insulin sthaayi 29 microiu/ml ledhaa 174 pmol/ell kante ekkuvagaa unte insulin nirodhakatanu suuchistumdi. chivari bhojanam tarvaata moodu gantala tarvaata kooda adhe sthaayilu vartistaayi.
glucose tolerance pareeksha.
diabetes mellitus nirdhaaranaku upayoginche glucose tolerance test (gtt) samayamlo, upavaasa roogi 75 graamula noti motaadu glucose teesukuntaadu. taruvaata rendu gantallo raktamlo glucose sthaayilanu kolustaaru.
vivarana anedi evari maargadarsakaalapai aadharapadi untundi. rendu gantala taruvaata 7.8 mmol/ell (140 engy/dl) kante takkuva glycemia saadhaaranamainadigaa pariganinchabadutundi, 7.8 mariyu 11.0 mmol/ell (140 nundi 197 engy/dl) madhya glycemia balaheenamaina glucose tolerance (igt) gaa pariganinchabadutundi, mariyu 11.1 mmol/ell (200 engy/dl) kante ekkuva ledhaa samaanamaina glycemia diabetes mellitusga pariganinchabadutundi.
noti dwara glucose sahanam pareeksha (ojititi) saadhaarana insulin nirodhakatalo saadhaaranamainadi ledhaa swalpamgaa asaadhaaranamainadi kaavacchu. tarachugaa, prarambha kolatalalo glucose sthaayilu perugutaayi, idhi insulin utpattilo post-praandiyal garishta sthaayini (bhojanam tarvaata) kolpovadaanni pratibimbistumdi. pareeksha podigimpu (marikonni gantalu) hypoglycemic "dip" nuu bahirgatam cheyavachu, idhi physiologic postprandial insulin pratispandana viphalamaina tarvaata insulin utpattilo atigaa peragadam phalitamgaa untundi.
hyperinsulinemic euglycemic bigimpu.
insulin nirodhakatanu parisoedhinchadaaniki mariyu lekkinchadaaniki bangaaru pramaanam "hyper insulinemic euglycemic clamp", dheenini hypoglycemia kaliginchakundaa perigina insulin sthaayini bharti cheyadaaniki avasaramaina glucose mottaanni kolustundi. idhi oka rakamaina glucose clamp technic. eee pareeksha clinical cair loe arudugaa nirvahinchabadutundi, conny vaidya parisoedhanaloo upayogistaaru, udaaharanaku, vividha aushadhaala prabhavalanu anchanaa vaeyadaaniki. saadhaaranamgaa glucose infusion retunu diabetes saahityamlo jinf viluvagaa suuchistaaru.
eee prakriyaku sumaru rendu gantala samayam padutundi. paridheeya sira dwara, insulin nimishaaniki nimishaaniki 10-120 myuu vadda infuse cheyabadutundi. insulin infusionnu bharti cheyadaaniki, raktamlo chakkera sthaayilanu 5 nundi 5.5 mmol/lii madhya nirvahinchadaaniki 20 saatam glucosenu infuse chestaaru. prati aidu nundi padhi nimishaalaku raktamlo chakkera sthaayilanu tanikhi cheyadam dwara glucose infusion raetu nirnayinchabadutundi.
pareeksha chivari muppai nimishaallo glucose infusion raetu insulin sunnitatvaanni nirnayistundi. adhika sthaayilu (7.5 mii. graa./nimisham ledhaa anthakante ekkuva) avasaramaite, roogi insulin-sensitivga untaaru. chaalaa takkuva sthaayilu (4 mii. graa./nimisham ledhaa anthakante takkuva) sareeram insulin charyaku nirodhakatanu kaligi undani suuchistaayi. 4 nundi 7.5 mg/nimisham madhya sthaayilu khachitamainavi kaavu, mariyu insulin nirodhakataku prarambha sanketam ayina "balaheenamaina glucose sahanam" nuu suuchistaayi.
glucose tracerla vadakam dwara eee praathamika saanketikatanu gananeeyamgaa meruguparachavacchu. glucose sthiramaina ledhaa rediyodhaarmika anuvulatho label cheyabadavachhu. saadhaaranamgaa upayoginche tracerlu 3-3h glucose (rediyodhaarmikata), 6,6 2h-glucose (sthiramgaa) mariyu 1-13 c glucose (sthiramgaa). hyperinsulinemic kaalam praarambhaaniki mundu, 3 gantala tracer infusion anedi glucose utpatti yokka besal retunu nirnayinchadaaniki veelu kalpistundi. bigimpu samayamlo, plasma tracer saandratalu mottam shareera insulin-prerepita glucose jeevakriyanu lekkinchadaaniki, alaage sareeram dwara glucose utpattini (i.ii., antarjanita glucose utpatti).
savarinchina insulin anachiveta pareeksha.
insulin nirodhakata yokka maroka kolata stanford vishwavidhyaalayamlo gerald reven abhivruddhi chesina savarinchina insulin anachiveta pareeksha. pareeksha euglycemic bigimputho baga sambandham kaligi untundi, takkuva operator-aadhaarita lopam. metabolic syndromeku sambandhinchina pedda parisoedhananu munduku teesukelladaaniki eee pareeksha upayoginchabadindi.
rogulu praarambhamlo intravenous infusion (IV) dwara 3 nundi 5 nimishaallo 5 millilitres saadhaarana lavanam loe 25 microgram actriotide (sandostatin) nuu prarambha bolus gaa andukuntaaru, aapai, endogenous insulin mariyu glucose sraavamnu anichivesenduku somatostatin (0.27 (0.27 yokka intravenous infusiontho nirantaram infuse cheyabadataayi. taruvaata, insulin mariyu 20 saatam glucose varusaga 32 mariyu 267 mg/m2/nimisham choppuna infuse cheyabadataayi. raktamlo glucose sunna, 30,60,90 mariyu 120 nimishaalalo tanikhi cheyabadutundi, aaa taruvaata, pareeksha yokka chivari aragantaku prati 10 nimishaalaku okasari tanikhi cheyabadutundi. sthiramaina-sthithi plasma glucose sthaayini (sspg) nirnayinchadaaniki eee chivari naalugu viluvalu sagatuna untaayi. 150 mg/dl kante ekkuva sspg unna vyaktulu insulin-nirodhakamgaa pariganinchabadataaru.
pratyaamnaayaalu.
bigimpu" saanketikata yokka sanklishta swabhaavaanni (mariyu kontamandi rogulalo hypoglycemia yokka sambhaavya pramaadaalu) batti, insulin nirodhakata kolatanu saralikrutam cheyadaaniki pratyaamnaayaalu prayatninchabaddaayi. modatidi homeostatic modal assessment (homa), mariyu iteevali paddhatulalo quantitative insulin sensitivity check index (kwikki) mariyu spina-grar, insulin sensitiviteeki kolata unnaayi. eee lekkinchina gurtulannee insulin nirodhakatanu lekkinchadaaniki upavaasa insulin mariyu glucose sthaayilanu upayogistaayi mariyu annee bigimpu adhyayanala phalitaalato sahetukamgaa sambandham kaligi untaayi.
nivaarana mariyu nirvahana.
aarogyakaramaina shareera baruvunu nirvahinchadam mariyu saareerakamgaa churukuga undatam insulin nirodhakatanu abhivruddhi chese pramaadaanni tagginchadamlo sahaayapadutundi.
insulin nirodhakataku praathamika chikitsa vyayamam mariyu baruvu taggadam. metformin mariyu theazolidinadians rendoo insulin sunnitatvaanni meruguparustaayi. prii diabetes mariyu type 2 diabetislaku metformin aamodinchabadindi mariyu insulin nirodhakataku saadhaaranamgaa soochinche mandulalo okatigaa maarindi.
diabetes prevention programme" (dii. pii. pii) type 2 diabetisku perige pramaadaanni tagginchadamlo vyayamam mariyu aaharam metformin kante daadaapu rendu retlu prabhaavavantamgaa unnayani choopinchindi. ayithe, dpp vichaaranalo palgonnavaru 2.8 samvatsaraala chivarilo kolpoyina baruvulo 40 saatam tirigi pondaaru, phalitamgaa jeevanasaili jokyam mariyu vichaarana yokka niyantrana vibhagalalo madhumeham abhivruddhi yokka idhe sanghatana jarigindi. epidemiological adhyayanaalalo, adhika sthaayi saareeraka shrama (rojuku 90 nimishala kante ekkuva) madhumeham pramaadaanni 28 saatam taggistundi.
antekakunda, saareeraka sikshana kooda saadhaaranamgaa oobakaayam ledhaa adhika baruvu unna pillalu mariyu koumaaradasalo (19 samvatsaraala kante takkuva vayassu unnavaaru) insulin nirodhakataku samarthavanthamaina virodhigaa kanipistundi. marson mariyu itarulu nirvahinchina 2016 kramabaddhamaina sameeksha mariyu meta-vislaeshanha prakaram.aerobic vyayamam upavaasam insulin taggimputoe mudipadi untundi; ayithe, nirodhakata mariyu mishrama vyayamam kaadu. pratighatana mariyu mishrama vyayamam yokka praamukhyatanu takkuva cheyavaddani rachayitalu hecharistunnaru, endukante eee rakamaina sikshana saadhaaranamgaa aerobic sikshana kante takkuva parisoedhana cheyabadutundi. mottammeeda, insulin nirodhakata mariyu bhavishyattulo jeevakriya mariyu hridaya sambandha vyaadhula purogatini nivaarinchadaaniki koumaaradasalo mariyu peddalalo saareeraka sikshananu upayoginchavacchu.
adhika-amylose mokkajonna nundi vachhe nirodhaka pindi, amylomise, aarogyakaramaina vyaktulalo, insulin nirodhakata unna vyaktulalo mariyu type 2 diabetes unna vyaktulalo insulin nirodhakatanu taggistundani choopabadindi.
konni rakaala polyunsaturated kovvu aamlalu (omega-3) insulin nirodhakatanu type 2 diabetisloki maarchavacchu, ayithe, omega-3 kovvu aamlalu insulin nirodhakatanu tippikotte parimita saamarthyaanni kaligi unnatlu kanipistaayi, mariyu type 2 diabetes sthaapinchabadina tarvaata avi prabhaavavantamgaa undavu.
charitra.
type 2 diabetisku insulin nirodhakata antarleena kaaranam kaavacchu anae bhavananu professor wilhelm falta modatisaarigaa munduku tecchi tecchi viyannaalo prachurinchaaru, mariyu mariyu landanlooni university college hospital medical centarku chendina surr harrold persival himsworth dwara sahakaramga dhruvikarinchabadindi; ayithe, compensatory insulin sraavam ekakaalamlo viphalamaithe tappa type 2 diabetes sambhavinchadu.
anukuula vivaranalu.
kontamandi panditulu insulin nirodhakata ledhaa oobakaayam nijamgaa jeevakriya rugmatalu kaavu, conny shareera avayavalanu lipotoxicity (raktapravaaham mariyu kanajaalaalo lipidla asurakshita sthaayilu) nundi rakshinchadaaniki uddesinchina nirantara kelareela migulu pratispandanalanu anukulikarinche pratispandanalu anie cheppadaniki chaalaa varaku velataaruh "oobakaayaanni oka pathology ledhaa vyadhiga pariganinchakudadu, conny sthiramaina kelareela migulaku saadhaarana, saareeraka pratispandanagaa pariganinchaali... asthipanjara kandaraalu mariyu kaaleyamtho sahaa insulin lakshya kanajaalaalo adhika sthaayi lipid perukupovadam phalitamgaa, lipid-nindina kanaala nundi glucosenu minahaayinchadam anedi lipogenic uparitalam marinta perukupovadaniki vyatiraekamgaa parihara rakshana anie soochinchabadindi."
insulin nirodhakata anedi parinaamaatmaka anusarana kaavacchane itara prabalamaina aalochanalalo podupu janyu parikalpana unnaayi. insulin nirodhakata mariyu type 2 diabetisku janyuparamaina bhaagam unte, eee samalakshanaalanu enchukoovaali anae amsaanni eee parikalpana levanettutundi. ayinappatikee, saadhaarana glycemic janabha mariyu diabetic janabha rendintiloonuu sagatu insulin nirodhakata perigindi.
zhe.vii. praacheena maanavula puurveekulaloo perigina karuvu samayaallo, perigina glucose nilvaku oka yantraamgaanni andinche janyuvulu prayojanakaramgaa untaayani neel pratipaadinchaaru. ayithe, neti aadhunika vaataavaranamloo, eee paristhiti ledhu.
pima bhaaratheeyula adhyayanaalalo aadharalu neelku viruddhamgaa unnaayi, idhi adhika insulin sunnitatvaalu unna vyaktulu ekkuva baruvu kaligi untaarani mariyu dheeniki viruddhamgaa insulin nirodhakata unna vyaktulu eee janabhalo sagatuna takkuva baruvu kaligi untaarani suuchistumdi.
aadhunika parikalpanalu insulin jeevakriya anedi oka saamaajika-paryaavarana anusarana anie suuchistunnaayi, sariiramlooni vividha bhagalaku shakti ketaayimpunu vaeru cheyadaaniki insulin saadhanamgaa untundi mariyu insulin sunnitatvam anedi saktini ekkada mallinchaalo maarchadaaniki anuvartanam. pravartanaa marpidi parikalpana insulin nirodhakata punarutpatti vyuuhaalu mariyu pravartanaa paddhatulanu maarchadaaniki rendu paddhatulaku daariteestundani perkondi. eee rendu vyuuhaalanu "r nundi k" mariyu "sainikudu nundi doutyavetta" gaa roopondinchaaru.aarr tuu keey vyuuhamloo maavi dwara insulinnu pindaaniki mallinchadam untundi. idhi pindamlo baruvu peragadaanni pradarsinchindi, conny perigina tallidandrula pettubadi (keey vyuuham) paddhatini soochinche talli kaadu. sainikudu nundi doutyavetta" loe insulin kuu asthipanjara kandaraala sunnitatvam glucosenu medaduku mallinchavacchu, dheeniki insulin grahakaalu avasaram ledhu. idhi vividha adhyayanaalalo abhignaa abhivruddhilo perugudalanu choopinchindi.

