garbhasaya sankocham

garbhasaya sankochaalanu ruthu chakram mariyu prasava samayamlo sambhavinche garbhasaya mruduvaina kandaraala kandaraala sankochaalanu garbhasaya sankochaalanu antaaru. garbhasaya sankochaalanu ruthu chakram antataa garbhinii kaani sthithilo mariyu garbham antataa sambhavistaayi.
ruthu chakram antataa.
ruthu chakram antataa sambhavinche garbhasaya sankochaalu, "endometrial taramgaalu" ledhaa "sankocha taramgaalu" anie kooda pilustaaru, ivi myometrium yokka upa-endometrial poranu matrame kaligi unnatlu kanipistaayi.
follicular mariyu luteal dasha.
prarambha follicular dasalo, garbhinii kaani mahilalo garbhasaya sankocham nimishaaniki 1-2 saarlu mariyu saadhaaranamgaa 30 mmhechji ledhaa anthakante takkuva takkuva teevratatoo chivari 10-15 seconlalo sambhavistundi. eee upa-endometrial poralo eastrogen mariyu progesterone grahakaalu samruddhiga untaayi. andotsargamu vaipu sankochaalu nimishaaniki 3 nundi 4 varaku perugutaayi. luteal dasalo, frequency mariyu teevrata taggutundi, bahusha edainaa implantationnu sulabhataram cheyadaaniki.
rutusraavam.
implantation jaragakapothe, sankochaala tarachudanam takkuvagaa untundi; conny rutusraavam samayamlo teevrata natakeeyamgaa 50 mariyu 200 mmhechji madhya perigi prasava-vanti sankochaalanu utpatti chestundi. eee sankochaalanu konnisaarlu "ruthu timmiri" anie pilustaaru, ayithe aaa padaanni saadhaaranamgaa ruthu noppiki kooda upayogistaaru. eee sankochaalu asoukaryamgaa ledhaa badhakaramga kooda undavacchu, conny avi saadhaaranamgaa prasava samayamlo sankochaalu kante gananeeyamgaa takkuva badhakaramga untaayi. baadhaakaramaina sankochaalanu diasmenoria antaaru.
sankochaala disaatmakata.
ruthu chakram samayamlo garbhasaya sunnitamaina kandaraala yokka mayosin vyakteekaranalo maarpu garbhasaya sankochaala disalalo maarpulaku kaaranamani oohinchabadindi.
pani.
garbhasaya sankochaalanu sahaja prasava prakriyaloo bhaagamgaa untaayi (i.ii., sijerian vibhagam dwara kaadu). prasavam samayamlo, garbhasaya sankochaalanu episodic mariyu samanvayarahita nundi adhika samanvayamtho maarchutaaru. eee maarpu saadhaaranamgaa raatri samayamlo sambhavistundi, idhi naadii niyantrananu suuchistumdi mariyu garbhasayamloni ottidini gananeeyamgaa penchutundi. kontamandi mahilalu prasavaniki mundhe sankochaanni anubhavinchavacchu. ivi broxton hicks sankochaala, veetini konnisaarlu "tappudu shrama" anie pilustaaru."
oxytosine.
oxytosine anae harmon garbhasaya sankochaalanu prerepistundi mariyu saadhaaranamgaa prasavaanni prerepistundi. oxytosine sareeram dwara sahajamgaa utpatti cheyabadutundi mariyu 1950la nundi synthetic pharmaceutical roopamlo kooda andubaatulo undhi. yea ruupamloonainaa, oxytosine prasava prakriyanu vegavantam cheyadaaniki garbhasaya sankochaalanu prerepistundi. oxytosine utpatti mariyu sraavam saanukuula pratispandana yantraangam dwara niyantrinchabadutundi, ikkada daani prarambha vidudala, sahajamgaa ledhaa aushadha roopamlo, marinta oxytosine utpatti mariyu vidudalanu prerepistundi. udaaharanaku, prasava praarambhamlo garbhasayam sankochinche samayamlo oxytosine vidudalainappudu, idhi marinta oxytosine utpatti mariyu vidudalanu prerepistundi mariyu sankochaala vyavadhi, teevrata mariyu frequencylo perugudalanu prerepistundi. eee prakriya teevrata mariyu pounahpunyamlo sammelanamavutundi mariyu trigger charya aagipoye varaku konasaagutundi.
prostaglandins.
prasava samayamlo rakta plasma mariyu amneotic dravam loe prostaglandins gaadata perugutundi. eee inflammatory madhyavartulu prasavaanni prerepinchadaaniki myometrial sankochaalanu prothsahistaaru. prostaglandinlu prasavam samayamlo gyap junction nirmaanam mariyu connexin-43 vyakteekaranalo maarpulaku kooda sambandhinchinavi.
udvegamlo.
garbhasaya mariyu yoni sankochaala saadhaaranamgaa stree laingika uddeepana samayamlo, laingika udrekam mariyu udvegamto sahaa jarugutaayi.
monetarlu.
garbhasaya sankochaalanu cardiotocography dwara paryaveekshinchavachchu, dheenilo oka parikaranni talli charmampai ledhaa neerugaa pindam talapai atikistaaru. garbhasaya godaloni oka bhaganni chadunu cheyadaaniki avasaramaina ottidi antargata ottiditoe sambandham kaligi untundi, tadwara daani anchanaanu andistundi.
drexel vishwavidhyaalayamlo abhivruddhi chendutunna oka rakamaina paryaveekshanha saanketikata, belliband yokka allina fabricto vaahaka daaraalanu ponduparachutundi. sankocham pratispandanagaa fibers vistarinchinappudu, threadlu antenna laaga panicheestaayi mariyu avi teesukune sankethaalanu daetaanu nivedinche embeded rfid (radeo-frequency identification device) chipku pamputaayi.
yantraangam.
vishraanti rashtram.
garbhasaya mruduvaina kandaraala vishraanti pora sambhaavyata (vrest) −35 mariyu −80 emvi madhya unnatlu namodu cheyabadindi. itara kana rakaala vishraanti pora sambhaavyata maadirigaane, idhi naa +/keey + pump dwara nirvahinchabadutundi, idhi kanaantara sthalam kante kanaantara pradaesamloe naa + ayanla adhika saandrataku kaaranamavutundi mariyu kanaantara sthalam kante kanaantara pradaesamloe keey + ayanla adhika saandrataku kaaranamavutundi. tadanantaram, k + chaanallu Na + chaanalla kante ekkuva sthaayilo terichi undatam valla mottam saanukuula ayanla pravaham erpadutundi, phalitamgaa pratikuula sambhaavyata erpadutundi.
eee vishraanti sambhaavyata layabaddhamaina dolanalaku lonavutundi, veetini "nemmadigaa taramgaalu" anie pilustaaru mariyu nemmadigaa taranga sambhaavyata yokka antargata charyanu pratibimbistumdi. kanaantara mariyu bahya kana antaraala madhya ca2 +, Na +, k + mariyu cl− ayanla pampinheelo maarpula valla eee nemmadigaa vachhe taramgaalu sambhavistaayi, ivi aaa ayaanlalo pratidaaniki plasma pora yokka paaragamyatanu pratibimbistaayi. ayan fluxlo ituvanti maarpulaku k + pradhana ayan, idhi vividha k + chaanellalo maarpulanu pratibimbistumdi.
uttejakaramaina-sankocham.
garbhadhaarana samayamlo garbhasayam tappanisarigaa vikasistundi kabatti, myometrium yokka samanvaya naadii niyantrana kendramgaa kramabaddhikarinchabadatam asambhavam.
utsaaham.
garbhasaya mruduvaina kandaraala yokka excitation-sankocham kalayika kooda saadhaaranamgaa itara mruduvaina kandaraala maadirigaane untundi, calcium (ca2 +) loe kanaantara perugudala sankochaaniki daariteestundi.
naitrik oxide (ledhu) myometriumnu sadalinchadamlo mukhyamgaa prabhaavavantamgaa untundi mariyu vaastavaaniki ginia pandhi ledhaa maanavetara primate myometrium kante maanavulalo 50 saatam (kii) takkuva nirodhaka saandratanu kaligi untundi.
vishraanti sthithiki punaruddharana.
vishraanti yokka garbhasaya mruduvaina kandaraala vidhanalu itara maanava mruduvaina kandaraala nundi gananeeyamgaa bhinnamgaa untaayi.
sankocham tarvaata Ca2 + nuu tolaginchadam valla mruduvaina kandaraala sadalimpu prerepistundi mariyu tadupari sankocham uddeepana kosam sarcoplasmic reticulum yokka paramaanu nirmaanaanni punaruddharistundi.
garbhasaya sankocham "ex vivo" nuu kolustundi.
naitikamgaa viraalamgaa icchina maanava garbhasaya kanajalalanu garbhasaya sankocham "ex vivo" nuu kolavadaniki upayoginchavacchu. eee prayogaalalo, isometric shakti utpattilo maarpulanu kolavadaniki avayava snaana vyavasthalo myometrium yokka vibhagalu erpaatu cheyabadataayi. kanajaalam saareerakamgaa churukuga undani nirdhaarinchadaaniki kriyaatmaka tanikheelanu anusarinchi, sanchita ekagrata-pratispandana vakrarekha (sii. sii. aarr. sii) nuu srushtinchadaaniki saandratalanu penchutuu avayava snaanaaniki sammelanaalanu jodinchavachhu.
garbhasaya sankocham "ex vivo" nuu kolavadam yokka mukhya prayojanam jaatula vyatyaasaalanu tolaginche saamarthyam. udaaharanaku, magnitium janthu adhyayanaalalo mariyu "inn vitro" loe myometrial sankocham taggistundi, idhi clinical adhyayanaalalo adhe prabhavanni pradarsinchadu. peptide harmon relaxin elukalu, elukalu mariyu pandulalo garbhasaya sankocham nirodhistundani chuupabadinappatikii, idhi maanavulalo garbhasaya sankocham nirodhinchadu.

