elastase

molecular biologylo, elastage anedi proteinlanu vichchinnam chese "proteases (peptidages)" taragatiki chendina enjaim. mukhyamgaa, idhi serin protease.
roopaalu mariyu vargeekarana.
elastage kosam enimidi maanava janyuvulu unnaih
konni bacteria ("sudomonas eruginosa" thoo sahaa) kooda elastesnu utpatti chestaayi. bacterialo, elastage anedi virus karakamga pariganinchabadutundi.
function.
elastase elastine anae saage peechuni vichchinnam chestundi, idhi kollajantho kalisi, bandhana kanajaalam yokka yaantrika lakshanaalanu nirnayistundi. neutrophil roopam "e" yokka "bayati pora protein a" (ompa) nuu vichchinnam chestundi. kolai "mariyu itara gram-negative bacteria. shigella virus kaarakaalanu vichchinnam cheyadamlo elastage mukhyamaina roganirodhaka paatranu kooda kaligi undhi. lakshya proteinlalo peptide bandhaala cheelika dwara idhi saadhinchabadutundi. glycine, alanine mariyu valin vanti chinna, hydrophobic amaino aamlaala carboxyl vaipu unnavi vicchinnamaina nirdishta peptide bandhaalu. idhi elaa saadhinchabadutundane daani gurinchi marinta telusukovadaaniki, serin protease chudandi.
vyaadhiloo maanava elastase paatra.
a1at.
elastase anedi acute-faze protein α1-antitrypsin (a1at) dwara nirodhinchabadutundi, idhi elastase mariyu tripsin yokka kriyaaseela pradaesaaniki dadapuga tirigi maarchaleni vidhamgaa bandhistundi. a1at saadhaaranamgaa kaaleya kanaala dwara seeramloki sravistundi. alfa-1 antitrypsin lopam lopam elastase dwara saage peechu yokka nirodhana rahita naasanaaniki daariteestundi; pradhana phalitam emphysema.
chakriya neutropenia.
arudaina vyaadhi chakriya neutropenia ("chakriya hematopoisis" anie kooda pilustaaru) anedi 21 rojula vyavadhilo neutrophil granulocyte lekkala hecchutaggula dwara vargeekarinchabadina autosomal aadhipatya janyu rugmata. neutropenia samayamlo, rogulaku infectionla pramaadam untundi. untundi, eee vyaadhi elaa-2/elane janyuvulooni rugmatalato mudipadi undhi. puttukatho vachhe neutropenia yokka itara roopaalu kooda elaa-2 utparivartanaalato mudipadi unnatlu kanipistaayi.
itara vyaadhulu.
antibodies samakshamlo bullus pemphigoid anae charma paristhitiloo pokkulu raavadaaniki neutrophil elastase baadhyata vahistundi. idhi pottikadupu bruhaddhamani raktanaalaala (aaas) mariyu deerghakaalika obstructive pulmonary disease (siopidi) erpadatamlo kooda paatra poeshistumdi.
vyaadhiloo bacteria elastase paatra.
elastase bigutu kuudalini debbateestundani, kanajaalaaniki proteolytic nashtanni kaligistundani, saitokinlu mariyu alfa proteiness inhibitornu vichchinnam chestundani, immunoglobulin eah mariyu zii (aiga, igg) nuu cheelchivestundani, mariyu c3bi, puuraka vyavasthalo oka bhaagam, mariyu phagocytosislo palgonna maroka puuraka anuvu kosam neutrophils meeda graahakamaina mariyu rendintinee cheelchivestundani choopabadindi. igaa, igg, igg mariyu mariyu cheelika phagocytosis dwara bacterianu champe neutrophils saamarthyaanni tagginchadaaniki dohadam chestundi. eee karakalanni kalisi maanava rogalakshana saastraaniki dohadam chestaayi.

