transglutaminase

transglutaminagelu anevi prakrutilo pradhanamgaa glutamine avasheshaala side chainla yokka γ-carboxamide samuuhaalu (-(c = o) nh2) mariyu lysine avasheshaala side chainla yokka ε-amaino samuuhaala (-nh2) madhya isopeptide bandham erpadataaniki utprerakam chese enjaimlu, taruvaata ammonia (nh3) vidudala avutundi. lysine mariyu glutamine avasheshaalu peptide ledhaa proteintho kattubadi undaali, tadwara eee cross-linking (ververu anuvula madhya) ledhaa intramolecular (oke anuvu lopala) praticharya jaragavacchu. transglutaminase dwara erpadina bandhaalu proteolytic ksheenata (proteolysis) kuu adhika nirodhakatanu pradarsistaayi. pratispandana emitante
transglutaminagelu protein/peptide kattubadi unna glutamine avasheshaala yokka side chain carboxamide groupulo praadhamika amine amine loe kooda cheravacchu, tadwara isopeptide bandham erpadutundi.
eee enjaimlu neeti samakshamlo glutamine avasheshaalanu glutamic aamlam avasheshaalugaa kooda demidate cheyagalavu.
udaaharanaku, "streptomyces mobarensis"-bacteria nundi verucheyabadina transglutaminase, calcium-swatantra enjaim. itara transglutaminesslo ksheerada transglutaminesslaku cofactorga Ca2 + ayanlu avasaram.
transglutaminagelu mottamodata mottamodata vivarinchabaddaayi. transglutaminagelu yokka khachitamaina jeevarasaayana charya charya raktam gaddakattadam protein karakam karakam kanugonabadindi.
udaaharanalu.
maanavulalo tommidi transglutaminagelu vargeekarinchabaddaayi, veetilo enimidi transamidation praticharyalanu utprerakam chestaayi. eee tigeslu moodu ledhaa naalugu-domine samsthanu kaligi untaayi, immunoglobulin lanty domainlu kendra utpreraka domine chuttoo untaayi. pradhana domine papine-lanty protease suupar family (ca clan) kii chendinadi mariyu sis-hiss-asp utpreraka trayamnu upayogistundi. protein 4.2, byaand 4.2 anie kooda pilustaaru, idhi maanava transglutaminase kutumbaaniki chendina utprerakamgaa kriyaarahita sabhyudu, idhi utpreraka trayam vadda CIS nundi ALA pratyaamnaayaanni kaligi untundi.
bacterial transglutaminagelu oke rakamaina madata core kaligina single-domine proteins. konni bacterialalo kanipinche transglutaminase sis-asp diadpy nadustundi.
jeevasambandhamaina paatra.
transglutaminagelu vistrutamgaa cross-linked, saadhaaranamgaa karagani protein paalimarlanu yerparustaayi. eee jeeva polymerlu oka jeevi addamkulu mariyu sthiramaina nirmaanaalanu srushtinchadaaniki entho avasaram. raktam gaddakattadam (gaddakatte karakam xiii), charmam mariyu juttu udaaharanalu. utpreraka praticharyanu saadhaaranamgaa tirigi pondalenidigaa chuustaaru, mariyu vistrutamaina niyantrana yantraamgaala dwara nisitamgaa paryaveekshinchaali.
vyaadhiloo paatra.
karakam xiii (arudaina janyu paristhiti) lopam raktasraavanku daariteestundi; asaadhaaranatanu saricheyadaaniki mariyu raktasraavam pramaadaanni tagginchadaaniki kendrikruta enjaimnu upayoginchavacchu.
anty-transglutaminase pratiroedhakaalu udarakuhara vyaadhiloo kanipistaayi mariyu eee paristhitini vargeekarinche aahara gliadinku pratispandanagaa chinna pregu debbatinadamlo paatra poeshistaayi. sambandhita paristhitiloo dermatitis herpetiformis, dheenilo chinna pregu maarpulu tarachugaa kanipistaayi mariyu idhi gliadine kaligina godhuma utpattulanu aahaaramlo minahaayinchadaaniki pratispandistundi, epidermal transglutaminase pradhana auto antigen.
huntington mariyu parkinsons vanti naraala vyaadhulatoe baadhapadutunnavaaru asadhaaranamgaa adhika sthaayilo oka rakamaina transglutaminase, tissue transglutaminase kaligi undavacchani iteevali parisoedhanalu suuchistunnaayi. idhi chaalaa matuku avasaram laenappatikee, huntington vyaadhiki kaaranamayye protein aggregates erpadatamlo kanajaala transglutaminase prameyam undavacchani oohinchabadindi.
caratinocyte transglutaminesslo utparivartanalu lamellar ichthiyosislo chikkukunnayi.
nirmaanaatmaka adhyayanalu.
2007 chivari natiki, eee taragati enjaimla kosam 19 nirmaanaalu parishkarinchabaddaayi, pdb accession kodlu,,,,,,,,,,,,,,,,,, mariyu.
paarisraamika mariyu paaka anuvartanaalu.
vaanijya aahara prosessinglo, transglutaminessnu proteinlanu okadaanitoe okati bandhinchadaaniki upayogistaaru. transglutaminase upayoginchi tayaaru chesina aahaaraalaku udaaharanalalo anukarana peetha maamsam mariyu chepala bantulu unnaayi. idhi vaanijya parimaanaalalo () streptomysis mobarensis puliyabettadam dwara utpatti cheyabadutundi ledhaa jantuvula raktam nundi sekarinchabadutundi, mariyu proses chesina maamsam mariyu chepala utpattula utpattitoe sahaa vividha prakriyalalo upayoginchabadutundi.
suurimi ledhaa haam vanti protein adhikamgaa unde aaharaala aakrutini meruguparachadaaniki transglutaminessnu binding agentga upayoginchavacchu.
bovin mariyu porsain muulaala nundi vachhe thrombin-fibrinogen "maamsam jiguru" jiguru" european union antataa aahara sankalitamgaa nishedhinchabadindi. transglutaminase anumatinchabadindi mariyu prakatinchaalsina avasaram ledhu, endukante idhi prosessing sahayamga pariganinchabadutundi mariyu tudi utpattilo unde sankalitam kaadu.
molecular gastronomy.
kotta allikalanu ippatike unna ruchulatho kalapadaniki molecular gastronomylo kooda transglutaminessnu upayogistaaru. eee pradhana sravanti upayogaalato paatu, konni asaadhaarana aaharalanu roopondinchadaaniki transglutaminase upayoginchabadindi. british cheff heston bluementhal aadhunika vantalo transglutaminessnu pravesapettina ghanata pondaadu.
newyorkloni avant-gaard restaurant doubleudy ~ 50 cheff ayina vailee duffressney, bluementhal dwara transglutaminescu parichayam cheyabaddaadu mariyu transglutaminescu krutagnatalu teluputuu 95 saataaniki paiga royyalatho tayaaru chesina "pasta" nuu kanugonnadu.

