
nuciferrin

nuciferrin anedi "nymphia seeruleya" mariyu "nelumbo neusifera" mokkalalo kanipinche alcoloid.
1978loe praathamika psychopharmacological parisoedhana dopamine-receptor kaaryakalaapaalaku sambandhinchi sammelanam yokka vargeekarananu nischayamgaa nirnayinchalekapoyindi. oka vaipu, parisoedhanaatmaka adhyayanalu saampradayakamgaa "dopamine-receptor" uddeepanatoo sambandham unna pravartanaku aadhaaraalanu kanugonnayi stereotype, aakasmika motaru karyakalapalalo perugudala, conditioned egavetha pratispandananu nirodhinchadam mariyu noppi sunnitatvamlo perugudala phalitamgaa marphin analgesia nirodham. marovaipu, eee prarambha parisoedhanaatmaka adhyayanalu saampradayakamgaa "dopamine-receptor" digbandham "thoo mudipadi unna pravartanaku aadhaaraalanu kooda kanugonnayi sahajamaina motaru karyakalapalu taggadam, chali, catalepsy, spruha yokka trans lanty sthithulu.
nuciferrin kooda marphin analgesianu saktivantam cheyavachu. elukalalo madhyastha praanaantaka motaadu 289 mg/kiloga untundi. idhi nirmanatmakamga apomorphintho sambandham kaligi untundi.
nuciferrin vividha shotha nirodhakaalanu kaligi unnatlu nivedinchabadindi, bahusha paar delta activation dwara nuciferrin janthu namoonaalalo sokes2-aakt/stat3 signalling marganni anichivestundi. nuciferrin thoo maanava namoonaalalo sokes-2 maargaalanu lakshyamgaa chesukovadam cancer chikitsaku oka kotta chikitsa vidhananni andinchavacchu.