
samyojita estriol

progenon mariyu emenine anae brand paerlatoe vikrayinche conjugated estriol, eastrogen aushadham, idhi gatamlo mahilallo rutukramam aagipoyina lakshanaala chikitsa vanti eastrogen-rakam suuchanala kosam upayoginchabadindi. eee padam pratyaekamgaa garbhinii streela eastrogen adhikamgaa unde moothram nundi tayaaru cheyabadina eestriyol kanjugetla suutreekaranalanu suuchistumdi mariyu 1920luu mariyu 1930laloe mandulugaa upayoginchabadindi. garbhinii gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gurrapu gura vaidyamlo upayoginchina aushadha eastrogen yokka modati roopaalalo samyojita eestriyol okati. idhi noti dwara teesukobadindi.
samyugmita estriol yokka pradhana bhagalu estriol glucuronides mariyu kontavaraku estriol sulphates. eee enjaimnu vyakteekarinchae ksheerada grandhi, kaaleyam mariyu moothrapindaalu vanti kanajaalaalo β-glucuronidase dwara eastrogen glucuronideslanu sambandhita uchita eestrojenlugaa deglucuronidate cheyavachu. adevidhamgaa, eee enjaimnu vyakteekarinchae kanajaalaalo steroid sulfate dwara eastrogen salphetlanu sambandhita uchita eestrojenlugaa desulfate cheyavachu. tatphalitamgaa, eastrogen samyogaalu eestrogenik charyanu kaligi untaayi, avi samyogam kaani eestrojenlugaa marutayi.
proginone.
progenon anedi eastrogen yokka noti churukaina suutreekarana, dheenini adolph beautenand shering vadda abhivruddhi chesi 1928loe germanylo pravesapettaaru. idhi modati laingika harmon utpatti anie nivedinchabadindi, anduvalla vaidya upayogam kosam pravesapettina modati eastrogen utpatti kooda. progenon anedi modata andaasaya ledhaa plaasental saram, conny shering tvaralo aardhika kaaranaala valla garbham chivarilo unna mahilala muutraanni upayoginchadaaniki maarindi. eee rakamaina progenon tappanisarigaa emenine maadirigaane utpatti cheyabadindi, dheenini james collip airst vadda abhivruddhi chesi 1930loe kenadaalo pravesapettaaru (mariyu 1934loe).
progenon tayari kharchulanu marinta tagginchadaaniki, shering chivariki garbhinii gurrapu gurrapu gurrapu gurrapu muutraanni upayoginchadaaniki maarindi mariyu daani kotta utpattini progenon 2 anie pilichindi. 1941loe premarine (conjugated eekwain eestrojenlu) pravesapettadamto irest dheenini anusarinchindi. premarine tvaralo emeninnu adhigaminchindi mariyu appati nundi chaalaa vistrutamgaa upayoginche eestrojengaa matrame kakunda, uttara americalo atyanta vistrutamgaa suuchimchina aushadhaalalo okatigaa maarindi.
progenon mariyu emenine rendintiloonuu neetilo karige eestrojenla misramam untundi, idhi taruvaata ekkuvagaa eestriyol glucuronidega nirdhaarinchabadindi. garbhinii streela moothramlo eestrol glucuronide mariyu eestriyal sulfate vanti eestriyol yokka samyogaalu 90 saataaniki paiga eestrojenlanu kaligi untaayi. eee samyogaalalo, 35 nundi 46 saatam varaku estriol glucuronidelu mariyu 15 nundi 22 saatam varaku garbham chivarilo estriol 3-sulfate; double conjugate estriol sulfate glucuronide (bahusha estriol 3-sulfate 16α-glucuronide) kooda sambhavistundi.
beautenand eee padaardhampai thana modati prachuranalo (1929loe athanu vaeru chesina) eestron nuu icchina paeru kooda proginan (taruvaata dheenini folliculin anie pilustaaru, chivariki eestron anae paerunu 1935 varaku sweekarinchaledu). progenon mariyu progenon 2 kakunda, progenon-bii (estradiol benzoate), progenon-dii (estradiol; "dihydroxystrine"), progenon-dipi (estradiol dipropionate), progenon-sii (ethinylestradiol), projinova (estradiol valerate), mariyu progenon depo (estradiol valerate, estradiol undessilate) vanti shering dwara vikrayinche vividha itara eestrogenik utpattulalo kooda progenon paeru upayoginchabadindi.
emenine.
emenine anedi eastrogen yokka noti churukaina suutreekarana, dheenini james collip airst vadda abhivruddhi chesi 1930loe kenadaalo mariyu 1934loe united stateslo pravesapettaaru. idhi modata maanava maavi nundi pondina saram. edho oka samayamlo, idhi garbham chivarilo unna mahilala moothram yokka saaramgaa maarchabadinatlu telustondi, idhi kuurpuloo samanamga undedi conny muulam kante takkuva khareedainadi, mariyu tappanisarigaa progenon maadirigaane utpatti, idhi shering vadda adolph beautenand abhivruddhi chesina sambandhita eastrogen mariyu germanylo pravesapettabadindi. eastrogen utpattulu vaidya upayogam kosam vikrayinchabadina mottamodati noti churukaina eestrojenlu.
emenine mariyu proginan tayari kharchulanu tagginchadaaniki, irest mariyu shering chivariki garbhinii gurrapu gurrapu muutraanni (indulo samyojita gurrapu eestrojenlu, pradhanamgaa eestron sulfate untaayi) upayoginchadaaniki marai mariyu vaari kotta utpattulanu varusaga premarine mariyu proginan 2 anie pilichevi. premarine 1941loe irest chetha pravesapettabadindi mariyu idhi chaalaa vistrutamgaa upayoginche eastrogen matrame kakunda, uttara americalo atyanta vistrutamgaa suuchimchabadina aushadhaalalo okatigaa maarindi.
emenine mariyu progenon rendintiloonuu neetilo karige samyoga eestrojenla misramam untundi, taruvaata ivi ekkuvagaa eestriyol glucuronidega nirdharinchabaddayi. garbhinii streela moothramlo eestrol glucuronide mariyu eestriyal sulfate vanti eestriyol yokka samyogaalu 90 saataaniki paiga eestrojenlanu kaligi untaayi. eee samyogaalalo, 35 nundi 46 saatam varaku estriol glucuronidelu mariyu 15 nundi 22 saatam varaku garbham chivarilo estriol 3-sulfate; double conjugate estriol sulfate glucuronide (bahusha estriol 3-sulfate 16α-glucuronide) kooda sambhavistundi.<eastradiol mariyu eestron vanti asamyojita eestrojenla maadirigaa kakunda, eestrojenlu noti dwara churukuga undevi.

