shamyul charche

shamyul charche (janavari 12,1930-janavari 29,2019) oka american hematologist mariyu zaan hopkins vishwavidhyaalayamlo professor. pradhanamgaa african puurveekulanu prabhaavitam chese baadhaakaramaina mariyu konnisaarlu praanaantakamaina rakta rugmata ayina sikil sell vyaadhiki modati prabhaavavantamaina chikitsanu kanugonna parisoedhanaa brundaaniki ayana naayakatvam vahinchaaru.
vrutti.
athanu athanu oberlin kalaasaala nundi bachelor degreeni pondaadu mariyu athani emm.dii. emm.dii newyork vishwavidyaalayam school off medicine nundi degree. athanu athanu zaan hopkins facultylo cheraadu mariyu mariyu zaan hopkins hospital yokka hematology vibhaagaaniki director ayyadu. athanu pathology mariyu medicine vibhagalalo professorga professorga padavee viramana chesaadu.
sikil sell vyaadhi.
athanu sikil sell vyaadhi chikitsanu kanugonnanduku baga prasiddhi chendaadu, idhi united stateslo 70,000 mandiki paiga prajalanu, pradhanamgaa african americanlanu prabhaavitam chese vamsapaaramparya rakta rugmata. eee vyaadhi erra rakta kanaalapai daani prabhavam nundi daani paerunu pondutundi, ivi peddavaarilo haemoglobin yokka pradhana roopam ayina haemoglobin eah nuu prabhaavitam chese mutation kaaranamgaa vaati saadhaarana gundrani aakaram nundi koona, sikil aakarapu kanaalugaa vakreekarinchabadataayi. kanaalu jabbupadinapudu avi tarachugaa aasupatrilo cheradam, marpidi mariyu balamaina noppi mandulu avasaramayye teevramaina noppi yokka punaraavruta bhaagaalanu kaligistaayi. dheeniki chikitsa ledhu. 1980la praarambhamlo, cancer aushadhamaina hydroxyuria vyaadhi lakshanaalanu tagginchadaaniki sahaayapadutundaa anie chuudataaniki charche netrutvamloni brundam hopkinslo kontamandi rogulanu pareekshinchadam praarambhinchindi. hydroxyuria chikitsa graheetala raktamlo haemoglobin eff sthaayilanu penchutundani vaaru kanugonnaru, idhi pradhanamgaa pindam (mariyu saadhaaranamgaa peddalalo takkuva sthaayilalo matrame) tayaaru chesina haemoglobin yokka oka roopam, idhi sikil sell mutation dwara prabhaavitam kaadu.
phalitaalu prothsaahakaramgaa unnaayi, kabatti kabatti athanu mariyu 20 samvatsaraalugaa sikil sell vyaadhini parisoedhistunna pediatrician georg dover, oka niyantrita clinical trialnu praarambhinchaaru. phalitamgaa pareeksha samuuham yokka paristhitiloo entha naatakeeyamaina merugudala undhi antey vichaarananu mundugaane nilipivesaaru, tadwara niyantrana vishayaala (placebo sweekarinchevaaru) chikitsa nundi prayojanam pondavacchu. sikil sell vyaadhi unnavaarilo prayojanakaramaina prabhaavaala hydroxyuria yokka tadupari parisoedhana bahula vidhaanaalanu (inflammatory white blood sels mariyu plateletla anachivethatho sahaa) velladinchindi, conny haemoglobin eff yokka perigina sthaayilu ippatikee mukhyamaina paatra poeshistaayani bhaavistunnaaru.
vyaktigata jeevitam.
oberlinlo inca under graduatega unnappudu athanu patricia konnamacher chaarchenu kalusukuni vivaham chesukunnadu. aame oka pramukha vaidyuraalu ayyindi, 50 samvatsaraalaku paiga hopkins adhyaapakulalo panichesindi, mariyu pathology, medicine mariyu oncology yokka vishishta professor emeritusga padavee viramana chesindi. vaaru vaaru aame maraninche varaku 64 samvatsaraalu vivaham chesukunnaru, mariyu oka biddanu kaligi unnaaru. ayana 2019 janavari 29naa 89 samvatsaraala vayasulo maraninchaaru.

