
tardive psychosis

tardive psychosis anedi neuroleptics yokka deerghakaalika upayogam valla kalige psychosis yokka oohaatmaka roopaaniki oka padam. idhi modatisaarigaa 1978loe pratipaadinchabadindi, conny 1980la chivari natiki prashninchabadindi. neuroleptic mandulu taggutuu prabhaavavantamgaa maaradam, adhika motaadulu avasaramavadam ledhaa adhika motaadulaku spandinchanappudu psychosis talettavacchani oohinchabadindi. 
schizophrenia yokka neuroleptic chikitsaku sambandhinchina aneka vibhina mariyu paraspara sambandham laeni drugvishayaala kalayikaga "tardive psychosis" nuu baga varninchinatlu moolyaankanam suuchistumdi." 
konni vyasalu tardive psychosisnu suupar sensitivity saikosisto polchayi. ayithe, rendodi yokka lakshanaala vivaranalu modatidaanitoe saripoladam ledhu. nirdishta suupar sensitivity psychosis vyasalu mandula nirodhakatapai kakunda, closapintho anubandhinchabadina manasika mandula upasamharana nepathyamlo manasika bhagalapai drushti pedataayi. tardive psychosisku sambandhinchina oka oohaatmaka paristhiti, tardive diasmentia kooda prashninchabadindi.
vivarana.
saiddhaantika tardive psychosis schizophrenia nundi bhinnamgaa untundi mariyu dopamine ksheenata dwara prastuta (dopaminergic) anticycotics vadakam dwara prerepinchabadutundi mariyu vaati deerghakaalika upayogam, tardive diaskinesia valla kalige telisina dushprabhaavaaniki sambandhinchinadi.
nigrostriatal margalalo dopaminergic niyanthranatho paatu, chaalaa mandhi parisoedhakulu dopaminergic niyantrana mesolymbic ledhaa mesocartical margalalo sambhavinchavacchani suuchimchaaru, idhi asalu sthaayiki minchi manasika rugmata marinta digajaaradaaniki daariteestundi. eee drugvishayaanni 'tardive psychosis' ledhaa 'suupar sensitivity psychosis' anie pilustaaru.
1978 mariyu 1989loe tardive psychosis paie parisoedhana jarigindi, mariyu appudappudu parisoedhana konasaagutundi. konni adhyayanalu idhi manasika maandyam mariyu sambhaavyamgaa, vibhajanatho mudipadi undani kanugonnayi. edainaa aalasyamaina paristhitulu unnavaariki closapine oka empikagaa migilipoyindi, conny idhi rakta diascressialanu srushtinchagaladu kabatti, dheeniki tarachugaa rakta pani, alaage itara teevramaina dushprabhaavaalu avasaram, idhi clinical practicelo ekkuvagaa takkuvagaa upayoginchabadutundi. tardive psychosis adhyayanam konasaagutunnappatiki, idhi ippatikee oka vaastavamgaa sthaapinchabadaledu, ayithe tardive diaskinitianu srushtinchakapovadam loe nmda receptor modulatorlu (glutamate antagonists) vanti anticycotics yokka adhyayana taragatulu eee paristhitini srushtinchavani telusu.