
azalide

azithromycin vanti ajalaidlu macrolide antibiatics yokka oka taragati, ivi asalu macrolide (erythromycin) pradarsinchina paelavamaina aamla sthirathvaaniki pratispandanagaa modata tayaaru cheyabaddaayi. macrolide mariyu azalidela clinical mitimeerina upayogam taruvaata, streptocosy jaatulalo uparitala macrolide-azalide nirodhakatanu edurkovataniki ketolydelu abhivruddhi cheyabaddaayi. erythromycin kante ajalaidlu marinta saktivantamaina gram negative antimicrobial activity, assid stability mariyu side effect tolerability vanti aneka prayojanaalanu kaligi unnaayi. ajithromycintho konni aushadha paraspara charyalu unnappatikee, idhi saip4eah4 enjaimnu balaheenamgaa nirodhistundi.
nirmaanam.
ajalaidlu vaati 15-sabhyula macrolide valayamlo natrajani anuvunu kaligi untaayi, phalitamgaa munupati taram macrolydelatho poliste merugaina pharmacokinetic lakshanaalu mariyu ekkuva sthirathvam erpadataayi.saampradaaya macrolydelalo keaton samuuhaanni trutheeya amine samuuhamtoe bharti cheyadam valla ekkuva aamla sthirathvam labhistundi.beckman punarvyavastheekarana chudandi.
charya yokka yantraangam.
azalides bacterial 50 la ribosomal sabyuunittoe bandhistundi mariyu peptidile badilee rna translocationku aatamkam kaliginchadam dwara polypeptide podavunu nirodhistundi.
pharmacokinetics.
vartinche pharmacokinetic suuchikalu avi pradarsinche antibiatic anantara prabhavam kaaranamgaa free azalide auc24/mike, mariyu free azalide concentration/mike.vaati pedda parimaanamlo pampinhee mariyu lipophilic nirmaanam kaaranamgaa, ajalaidlu kanajaalamlo samarthavantamgaa kendrikaristayi.