
tirapazamine

tirapazamine (sr-4233) anedi oka prayogaatmaka cancer nirodhaka aushadham, idhi chaalaa takkuva sthaayi oxygen (hypoxia) vadda matrame visha radikalga sakriyam cheyabadutundi. maanava ghana kanitulalo ituvanti sthaayilu saadhaaranam, eee drugvishayaanni tumour hypoxia anie pilustaaru. anduvalla, ghana kanitula yokka hypoxic praantaalalo tirapazamine daani vishapuurita roopaaniki pradhaanyatagaa sakriyam cheyabadutundi. eee praantaalalo kanaalu radiotherapy mariyu chaalaa cancer nirodhaka mandula dwara champadaaniki nirodhakatanu kaligi untaayi. anduvalla saampradaaya cancer nirodhaka chikitsalatho tirapazamine kalayika mukhyamgaa prabhaavavantamgaa untundi. thala mariyu meda cancer mariyu gynaecological cancer unna rogulalo tirapazamine moodava dasha pareekshalo undhi, mariyu itara ghana kaniti rakalaku ilanti trials jarugutunnaayi.
rasaayanikamgaa idhi oka sugandha bhinnachakram dye-enn-oxide. dheeni puurti rasayana paeru 3-amaino-1,2,4-benzotriagin-1,4 dioxide. modata dheenini 1972loe kotta kalupu samhaarakaala kosam oka pareeksha karyakramam loe tayaaru chesaaru. dheeni clinical upayogam modata zeman mariyu itarulu varninchaaru."1986loe. clinical trialslo tirapazamine parimita prabhavanni matrame kaligi undagaa, merugaina cancer nirodhaka lakshanaalatoo aneka kotta sammelanaalanu abhivruddhi cheyadaaniki idhi pradhana sammelanamgaa upayoginchabadindi.
dasha III trial yokka naveekarana (tirapazamine, sysplatine, mariyu radiation verses sysplatine mariyu thala mariyu meda yokka adhunaatana polusula kana carcinoma kosam radiation (trogg 02.02, headstart): trans-tasman radiation oncology group yokka dasha III trial) hypoxia uniki kosam empika cheyani adhunaatana thala mariyu meda cancer unna rogulalo, chemoradiotherapyki TPZని jodinchadam, mottam manugadanu meruguparichindani etuvanti aadharalu dorakaledu.
DNA strand vichchinnaaniki kaaranamayye reactive oxygen jaatulanu utpatti cheyadaaniki TPZ yokka rendu sambhaavya paramaanu yantraamgaalu vistrutamgaa pariganinchabaddaayi. hypoxialo, bioreductive paristhitiloo, tii. pii. jedd pradhanamgaa hydroxyl ledhaa benzotriogenil raadikalsnu dii. enn. yea. haanikaramaina reactive jaatulugaa utpatti chestundani gamaninchabadindi.
2014 juun loe kaaleya cancerlo embolisationtho kalipi tirapazamine yokka kotta clinical faze I trial andukundi. eee adhyayanam kaaleya cancerlo embolisationtho icchinappudu, surakshitamgaa sahinchagala motaadunu optimize cheyadaaniki sahaayapadutundi.
ghana kanitula chikitsa sanklishtamgaa untundi, endukante ivi tarachugaa rakta naalaalatoe sarigga andinchabadavu, tadwara cytotoxic agentlaku bahirgatam cheyadaanni parimitam chestaayi. ayithe, phalitamgaa erpade hypoxic vaataavaranaanni sadviniyogam chesukovadaniki, avi praanavaayuvu-lopam kanajaalaalo pratispandinche jaatulugaa taggipoye varaku pratispandinchani aushadhaalanu roopondinchadam dwara prayatnaalu jarigaayi. idhi merugaina empikaku daariteestundani bhaavistunnaaru. udaaharanaku, antinoplastic agent tirapazamainpai azaquinoxaline dioxide function, tagginappudu reactive nitroxide raadikalsnu istundani choopabadindi.
samslaeshanha.
samshlaeshanhaloo modati dasha, sainamaidtho 2-nitroaniline (1) yokka ghaneebhavanam, bahusha 2 vanti gwanidin yokka prarambha nirmaanaanni kaligi untundi. idhi taruvaata heterocycle 3kii cyclise avutundi. hydrogen peroxidetho aakseekarana taruvaata tirapazamine (4) tayaareeni puurti chestundi.

