
rakam III hypersensitivity

allergy praticharyala zell mariyu combs vargeekaranalo type III hypersensitivity, roganirodhaka sanklishtatalu (antigen-antibody complexelu) perukupoyinappudu sambhavistundi, ivi sahaja roganirodhaka kanaala dwara taginantagaa clear cheyabadavu, idhi inflammatory pratispandana mariyu leukocytela aakarshanhaku daariteestundi. eee pratispandanaku daariteese moodu dasalu unnaayi. modati dasha roganirodhaka sanklishta nirmaanam, indulo pratirakshakaalu mariyu pratirakshakaalu bandhinchi, chalana roganirodhaka sanklishtatalanu yerparustaayi. rendava dasha roganirodhaka sanklishta nikshepana, eee samayamlo sanklishtaalu plaasmaanu vadili kanajaalaalo jama avtayi. chivaraku, moodava dasha taapajanaka praticharya, eee samayamlo shaastreeya maargam sakriyam cheyabadutundi mariyu prabhaavita kanajaalaalaku macrophaselu mariyu neutrophils niyaminchabadataayi. ituvanti praticharyalu roganirodhaka sanklishta vyaadhulaku purogaminchavacchu.
rakalu.
konni clinical udaaharanalu
itara udaaharanalu
vyadhikaaraka.
zell mariyu combs rakam III hypersensitivity praticharyalanu karige roganirodhaka sanklishtatalatoe kuudinavigaa nirvachinchaayi (cytotoxic pratirodhakaala dwara lakshyamgaa cheyagala pora-kattubadi unde antigenlanu kaligi unna rakam II hypersensitivitylaku viruddhamgaa). bahula-sthaayi antigen samakshamlo (ekakaalamlo bahula pratiroedhakaalanu bandhinchagaladi), pratirakshakaalu pratirakshaka samudaayaalu anie piluvabade pratirakshakaalu mariyu antigenla jaalakaalanu roopondinchadaaniki cross link cheyavachu. roganirodhaka sanklishtata yokka parimaanam daani lakshanaalanu nirnayinche mukhyamaina amsamha pedda roganirodhaka sanklishtatalu chinna vaati kante sulabhamgaa phagocytos cheyabadataayi, ivi vasculaturelo chikkukune dhoranini kaligi untaayi, indulo avi vaapunu rekettinchavacchu. ayithe, pedda roganirodhaka sanklishtatalu kooda effsy graahakaalato marinta utsaahamgaa bandhistaayi. roganirodhaka sanklishta parimaanam antigen mariyu antibody parimaanam rendintipai aadharapadi untundi, chinna sanklishtatalu antigen yokka adhika mariyu saapekshamgaa chinna mottamlo sambhavistaayi. roganirodhaka sanklishta lakshanaala yokka maroka nirnayadhikaram daani charge, mariyu mukhyamgaa antigen yokka chaarj. sanukoolamgaa charge cheyabadina antigenlu moothrapindaalu ledhaa charmamloni glomeruli yokka neelamaaliga pora vanti pratikuulamgaa charge cheyabadina uparitalaalato anubandham kaligi untaayi; ayithe idhi roganirodhaka sanklishtata erpadataaniki mundu antigenlu aaa pradaesaalaku akrama ravana cheyadam valla kooda kaavacchu. roganirodhaka sanklishtatalalo igg ledhaa igm marintagaa puuraka cascade yokka shaastreeya marganni niyaminchi, sii1kyooni bandhinchavachhu, dheeni phalitamgaa sii3 kaligi unna roganirodhaka sanklishtatalu erpadataayi. sii3 appudu erythrocytela uparitalampai sidi35 dwara bandhinchabadavachhu, idhi eee roganirodhaka sanklishtatalanu kuper kanaalu mariyu erra pulp macrophaselu vanti phagocytelaku andistundi. idhi mukhyamgaa pedda roganirodhaka sanklishtatalaku upayogapadutundi. edemaina, roganirodhaka sanklishtatalanu phagocytelaku jodinchadaanni paripuurakam prothsahinchinappatiki, eee prakriya effsy graahakaalache madhyavartitvam cheyabadutundi, kabatti eee prakriyaloo paripuurakam yokka paatranu phagocytosis yokka vegavantamainadigaa uttamamgaa chuustaaru. idhi mukhyamgaa gamaninchadaggadi endukante systemic lupus erythematosus, oka canonical rakam III hypersensitivity-nadiche swayam pratirakshaka vyaadhi, roganirodhaka sanklishtatala yokka pattudalanu prothsahinche compliment cascade yokka konni bhagala lopamtho mudipadi undhi.
roganirodhaka sanklishtatalu vyadhikaarakamgaa unde vidhanam sanklishtamainadi mariyu manaku telisina vaatilo chaalaa varaku orthus praticharya mariyu seeram anaaroogyam yokka prayogaatmaka namuunaala nundi teesukobaddaayi. eee namuunaalu pratispandanalo effsy grahakaalu aadhipatya paatra poeshistaayani, veetini anaphylatoxin sii5eah dwara paripuurakaramaina vyavastha dwara penchavacchu. roganirodhaka prabhava kanaala uparitalaalapai effsy graahakaala bandham anedi degranulation (ii.zii.maast kanaalu, histamine vimukti mariyu tadupari artikariyaku kaaranamavutaayi), phagocytosis, proo-inflammatory cytokins mariyu chemokins vidudala, platelet activation phalitamgaa gaddalu erpadataayi modalainavi.
sankethaalu mariyu lakshanaalu.
avakshepinche antigen yokka roganirodhaka ghnaapakasakti undaa ledhaa anae daanipai aadharapadi, pratispandana abhivruddhi chendadaaniki gantalu, rojulu ledhaa vaaralu kooda pattavacchu. saadhaaranamgaa, deposit cheyabadina roganirodhaka samudaayaalu taapajanaka pratispandananu prerepinchinappudu, prarambha antigen savaalu taruvaata oka vaaram clinical lakshanaalu udbhavistaayi. antibody aggregation yokka swabhaavam kaaranamgaa, gananeeyamaina asmotic mariyu hydrostatic gradient vadda rakta vadapotato sambandham unna kanajaalaalu (udhaa.zii. moothra mariyu sinovial dravam erpade pradaesaalu, moothrapindaala glomeruli mariyu ummadi kanajaalaalu) nashtam yokka teevratanu bharistaayi. anduvalla, vasculitis, glomerulonephritis mariyu arthuritis saadhaaranamgaa type III hypersensitivity pratispandanala phalitamgaa anubandhinchabadina paristhitulu.
hystopathology paddhatula krinda gamaninchinatlugaa, prabhaavita kanajaalaalo teevramaina necrotising vasculitis neutrophilic chorabaatuku, gurtinchadagina isinophilic nikshepana (fibrinoid necrosis) thoo patuga untundi. tarachugaa, immunofluorescence microscopyni roganirodhaka sanklishtatalanu drushyamaanam cheyadaaniki upayoginchavacchu. eee rakamaina hypersensitivityki charma pratispandananu orthus praticharyagaa suuchistaaru mariyu sthaanika eritima mariyu kontha inderation dwara vargeekarinchabadutundi. platelet aggregation, mukhyamgaa microvasculacherlo, sthaanika gaddakattadaaniki kaaranamavutundi, idhi blatchy raktasraavaalaku daariteestundi. idhi seeram anaaroogyam paristhitiki daariteese videshee antigen injectionku pratispandananu suuchistumdi.
allergy praticharyala zell mariyu combs vargeekarana yokka auchityam allergy yokka aadhunika avagaahanalo prashninchabadindi, mariyu idhi clinical aacharanalo parimita prayojanaanni kaligi undhi.

