
doubluenty1-inducible-signalling maargam protein 2

doubluenty1-inducible-signalling paath vae protein 2, ledhaa whisp-2 (ccn5 anie kooda pilustaaru) anedi maanavulalo "whisp2" janyuvu dwara encode cheyabadina oka metrixellular protein.
function.
proteinla yokka ccn kutumbam kanaala samslaeshanha, valasalu, vistarana, bhedamto sahaa vibhina cellular vidhulanu niyantristundi.
nirmaanam.
whisp-2 anedi sravinchina, extracellular matricks (ecm)-anubandha signalling matrixellular proteinla ccn kutumbam (ccn intercellular signalling protein) loe sabhyudu. ccn sankshipta namam gurtinchabadina kutumbamloni modati mugguru sabhyula nundi teesukobadindi, avi cr 61 (ccn 1), ctgf (bandhana kanajaala perugudala karakam, ledhaa ccn 2), mariyu nove. eee proteins, whisp1/ccn4, whisp2 (ccn5, eee janyuvu), mariyu whisp3 (ccn6) thoo kalisi sakasherukaalalo aruguru sabhyula ccn kutumbaanni kaligi untaayi. ccn proteins vilakshanamgaa enn-terminal sravinche signal peptidenu kaligi untaayi, taruvaata insulin lanty perugudala karakam binding protein (igfbp), vaan willebrand rakam sii repeats (vidabluesi), thrombospondin rakam 1 repeat (tsr), mariyu sii-terminal (siti) domine lopala systeine nott motifku samanamga naalugu nirmanatmakamga vibhina domainlu untaayi. ayithe, eee proteinla kutumbamlo whisp-2 khachitamgaa siti domine lekapovadam valla pratyekamainadi.
clinical praamukhyata.
vascular smooth kandara kanaalu, maanava garbhasaya myometrial kanaalu mariyu leomyoma kanaala vistarananu whisp-2 (ccn5) nirodhistundi. whisp-2 yokka ectopic vyakteekarana rommu cancer kanaala chalanasheelata mariyu aakramanaseelatanu kooda nirodhistundi. whisp-2 cardiac hypertrophy mariyu fibrosisnu kooda nirodhistundi, idhi siti domine lekapovatamto mudipadi unnatlu kanipinche prabhavam.

