
jackwellin barton

jackwellin keey. barton (jananam mae 7,1952, newyork city, envai), oka american rasayana shaastravetta. california institute off technologylo chaeradaaniki mundu aame hunter kalaasaala (1980-82) loe chemistry professorga, mariyu columbia vishwavidhyaalayamlo (1983-89) panicheesaaru. 1997loe aame orther mariyu marian hanis memorial professor off chemistry ayyaru mariyu 2009 nundi 2019 varaku caltechlo chemistry mariyu chemical injaneering vibhaagaaniki norman davidson nayakatva adhyakshuraligaa unnaaru. aame prastutam zaan zii. kirkwood mariyu orther eah. rasayana shaastra professor nois.
barton DNA yokka rasayana mariyu bhouthika lakshanaalanu mariyu jeeva karyakalapalalo vaati paatralanu adhyayanam chestundi. aame parisoedhana yokka praadhamika drushti double-stranded dna venta transverse electron ravana, dna nashtam mariyu marammattu yokka jeevasaastramlo daani chikkulu mariyu cancerku lakshita chemotherapy chikitsalu vanti padaartha shaastra anuvartanaalaku daani sambhaavyata. aneka itara avaardulalo, barton 2011 jaateeya sains patakam mariyu 2015 prestly patakaanni andukunnaru.
prarambha jeevitam mariyu vidya.
jackwellin aann cuppelman mae 7,1952naa newyork nagaramlo janminchaaru. aame tandri daadaapu oka dasaabdam paatu assemblylo panicheesaaru, taruvaata rendu dasaabdaala paatu newyork supreenkortulo trial jadjigaa panicheesaaru. aame tandri saam seeriyal hatya kesulo vichaarana nyaayamuurtulaloo okaru.
jackwellin cuppelman newyorkloni rivardelloni baalikala kosam reverdale country schoollo chadivaaru, akkada aame ganita upadhyayuralu srimati. rosenberg, baalura paatasaalalo calculus teesukoovadaaniki aamenu anumatinchaalani pattubattaru. rasayana saastramlo aame aasakti barnard kalasalalo praarambhamaindi, akkada aame bernis segal thoo bhouthika rasayana saastraanni abhyasinchindi. aame prayogasaala pani mariyu rasayana parivartanalanu ishtapadindi mariyu upadhyayuraliga segalnu preranagaa kanugondi. barnardlo thana chivari samvatsaramlo aame modati samvatsaram vaidya vidyaarthi donald zhe. nuu vivaham chesukundi. barton, aame bii andukundi.eah. 1974loe barnard kalaasaala nundi jackwalin cuppelman barton, summa cuum laad gaa.
aame appudu steffen zhe paryaveekshanhaloo columbia vishwavidhyaalayamlo akarbana rasayana saastraanni abhyasinchindi. lippered. columbialo unnappudu aame parivartana-loha samudaayaalu mariyu chemotherapyki vaati saadhyamayye anuvartanaalanu adhyayanam cheyadam praarambhinchindi. aame 1979loe akarbana rasayana saastramlo PhDని sampaadinchindi, "neelam platinum complexes yokka nirmaanam mariyu rasayana praticharyah nucleic aamlaalatoe antitumer platinum mandulu mariyu metallointercalation karakalu yokka paraspara charya".
vrutti mariyu parisoedhana.
aame Ph sampaadinchina taruvaata.dii. 1979loe columbia nundi, barton bell labs mariyu yael vishwavidhyaalayamlo post-doctoral niyamakalanu nirvahinchaaru, akkada aame robbert zii. thoo kalisi panicheesaaru. shulman. eest kanaala jeevakriyanu pariseelinchadaaniki aame nuclear magnetic resonance imaging technologyni upayoginchindi. barton 1980 nundi 1982 varaku hunter kalasalalo rasayana shaastra professor ayyaru, mariyu aame sonta prayogasaala, barton research groupnu abhivruddhi cheyadam praarambhinchaaru. vetagaadigaa unnappudu, aame dnatho jink ayanla paraspara charyalanu, taruvaata dnatho ruthenium (ii) mariyu cobalt (iii) complexela paraspara charyalanu adhyayanam chesindi. idhi aameku dna helix meeda sumaruga namuunaa samudaayaalanu roopondinchadaaniki mariyu ananciomerlaku sambandhinchina photophysical mariyu photochemical lakshanaalanu adhyayanam cheyadam praarambhinchadaaniki veelu kalpinchindi.
1980laloe, aame columbia vishwavidhyaalayaaniki velli, akkada 1983 nundi 1989 varaku bodhinchindi. aame 1986loe puurti sthaayi professor ayyaru mariyu columbialo rasayana shaastra vibhaagamlo padaveekaalam pondina modati mahila. aame parisoedhana DNA yokka bhouthika nirmaanaanni pariseelinchadaaniki argano-ruthenium complexela vaadakampai drushti pettindi. nicolus turo mariyu vijay kumarto kalisi aame ruthenium phenanthroline complexelu mariyu dna paraspara charyalanu adhyayanam chesindi mariyu nirdishta dna shrenulanu lakshyamgaa chesukuni binding anuvulanu roopondinchagaligindi. photosensitive ruthenium complexelu dna double helix kuu jodinchinappudu prakaasavantamgaa prakaasistaayi. rhodium complexelu dnaku jodinchabadinappudu, avi prakaasaanni kaliginche electronnu aakarshistaayi mariyu prabhavanni "aapivestaayi". columbialo aame unna samayamlo, barton DNA nirmaanaanni vislaeshimchae eee paddhati kosam rendu petentlanu pondindi.
1989loe, barton caltech vellaaru, akkada aame parisoedhana dnalo chaarj ravaanaapai drushti pettindi. pratyaekamgaa roopondinchina kairal metal complexelanu dna yokka probesga upayoginchadam dwara dna elaa debbatintondo mariyu marammatu cheyabadindo aame adhyayanam cheyagaligindi. dna aadhaarita roganirdhaarana pareekshalalo, dna antataa electronlu pravahistaayo ledho nirnayinchadaaniki complexelu upayoginchabadataayi. oka electron DNA venta kadalalekapothe, DNA merustune untundi, idhi DNA janyu anuvulo nashtam undani suuchistumdi.
aaa parisoedhana barton, catherine zhe. marfi, megaon newnies mariyu itarulu caltechlo chesinadi, DNA paie vegavantamaina suduura electron badilee aalochanaku maddatu ichindi, aamodinchabadina shaastreeya abhipraayaalanu savaalu chesindi mariyu gananeeyamaina vivaadaaniki kaaranamaindi. samvatsaraala tarabadi adhyayanala aadhaaramgaa, barton mariyu aame brundam dna wire laaga panichestundani, dnalo tappulanu gurtinchadaaniki mariyu saricheyadaaniki proteinlanu saricheyadaaniki veelu kalpinche oka rakamaina suduura signalingku maddatu istundani siddhaanteekarinchaaru. dna yokka eee drukpatham static libraryga dna yokka munupati drukpathaala kante lotainadi mariyu marinta dynamic.
dna double helix dwara electron-badilee rasayana shaastram yokka madhyavartitvaanni ardham chesukovadam kotta roganirdhaarana saadhanaala abhivruddhiki mariyu kotta chemotherapetics yokka saadhyamaina roopakalpanaku punaadi vesindi. barton, eric holmlin, shaanaa kellie mariyu mike hill dna mismachesnu gurtinchadaaniki sunnitamaina roganirdhaarana abhivruddhini anveshinchadaaniki company genome sainsesnu srushtinchaaru. appati nundi eee samsthanu bidi diagnostics konugolu chesindi.
barton 100 mandiki paiga graduate mariyu post doctoral vidyaarthulaku bodhinchaaru, veerilo chaalaa mandhi mahilalu. yuva mahilalaku matrame kakunda yuva saastravettalandariki adbhutamaina roll modal" gaa gurtinchabadina barton, "vignaana saastramlo mahilalaku neenu cheyagalige uttamamaina pani modata manchi shaastram cheyadame" anie itarulaku salaha istaaru. aame 1997loe orther mariyu marian hanis memorial professor off chemistry ayyaru. juulai 1,2009 nundi amaluloki vacchina california institute off technology yokka chemistry mariyu chemical injaneering vibhaagaaniki aame adhyakshuraligaa empikaindi.
barton 1993 nundi daau chemical bordulo sabhyuraligaa unnaaru. aame gilead sciences scientific advisory boardu (1989-2008) loe kooda panicheesaaru mariyu iteevala gilead directorla bordulo sabhyuraligaa ayyaru.
1990loe, aame thoti rasayana shaastravetta mariyu caltechlo professor ayina peater darvaannu vivaham chesukundi, ayana kooda jaateeya sains pataka vijaeta. aameku iddaru pillalu unnaaru, oka kumarte elizabeth (1991loe janminchindi), mariyu oka savati kumarudu andrew.
parisoedhana saaraamsam.
barton probe gurtimpu mariyu double helical dna yokka praticharyalaku parivartana loha samudaayaala anuvartanaanni pravesapettaadu. aame kairal metal complexelanu roopondinchindi, ivi dna-binding proteinla lakshanaalanu anukaristaayi, itara parisoedhakulaku eee swabhaavamlo prayogaalanu anukarinchadaaniki mariyu vislaeshimchadaaniki veelu kalpistundi. single bays asamatulyatalu ledhaa gaayaala maadirigaa, dna chaarj transport chemistry dna bays stacklo madhyavartitva bhangamlaku chaalaa sunnitamgaa untundani barton sthaapinchaaru. eee aavishkarana dna aadhaarita electrochemical sensorla abhivruddhiki muulastambhamgaa undhi.
avaardulu mariyu gowravaalu.
dna helix, long-range electron badilee yokka kotta lakshanaanni kanugonnanduku mariyu electron badilee bays jatala mariyu dna dynamics yokka stocking meeda aadharapadi undani choopinchinanduku bartonku 2011loe barak obama jaateeya vignaana patakaanni pradaanam chesaaru. aame prayogaalu DNA proteinlanu marammatu cheyadam dwara DNA gayalanu elaa gurtinchaalo mariyu DNA-madhyavartitva chaarj badilee kosam jeevasambandhamaina paatranu elaa pradarsinchaalo oka vyuuhaanni velladistaayi."itara puraskaralu