
asaadhaaranamaina protein sraavam

asaadhaaranamaina protein sraavam (err/golgi-swatantra protein sraavam ledhaa naan-classical protein egumati anie pilustaaru) anedi endoplasmic reticulum ledhaa golgi upakaranam nundi swatantramgaa plasma pora ledhaa extracellular matricks uparitalaaniki proteins pampinhee cheyabade vidhananni suuchistumdi. indulo inflammatory response ledhaa tumour-induced angiogenesis vanti sanklishta prakriyalalo keelakamaina paniteeru kaligina saitokinlu mariyu mitogenlu untaayi. eee proteinlalo ekkuva bhaagam adhika eukariotlalo prakriyalalo palgontayi, ayithe takkuva eukariotlalo kooda asaadhaaranamaina egumati vidhanam kanugonabadindi. saraina aakrutilo madathapette proteins kooda plasma poranu eee vidhamgaa daatagalavu, err/golgi maargam dwara ravana cheyabadina proteinla maadirigaa kakunda. rendu rakaala asaadhaarana protein sraavam ivih signal-peptid kaligina proteins mariyu err-signal peptide laeni cytoplasmatic mariyu nuclear proteins (1).
signal-peptide kaligina proteins.
eee proteins oka nirdishta signal-peptide kramaanni kaligi untaayi, idhi endoplasmic retikyulamloki anuvadinchabadutundi, ayithe, avi asadhaaranamgaa kana uparitalaanni cherukogalavu. vaatini coppy-puuta gala vesikil loe pyaak chesi, neerugaa plasma membrantho fuse cheyavachu ledhaa endosomal ledhaa lysosomal compartmentto fuse cheyavachu. pratyamnaayamgaa, vaatini coppy-lepita vesikil loe kooda pyaak cheyavachu mariyu golgeetho fuse cheyavachu (plasma membrane cherukune mundu) ledhaa neerugaa plasma membraneku pampinhee cheyavachu.
cytoplasmatic/nuclear sravinche proteins.
karige proteins naan-vesicular mariyu vesicular mechanisms dwara kana uparitalaanni cherukogalavu. naan-vesicular mechanisms proteinlanu extracellular space loki pondadaaniki carriernu upayogistaayi (udaaharanaku phosphatidilinosital-4,500-bisphosphate). vesicular mechanisms lysosome-aadhaarita maargam, microvasical shedding ledhaa multivasicular baadeela biogenesisnu upayoginchavacchu.