
gennifer lippinkat-swartz

gennifer lippinkat-swartz howard hugs medical institute yokka genelia research campaslo senior group leader mariyu genelia vadda neuronal sell biology prograam vyavasthaapaka sabhyudu. gatamlo, aame 1993 nundi 2016 varaku national institute off healthlo unis kennedy shriver national institute off chiled health und human developmentlo intrameral research vibhaagamlo sell biology mariyu metabolism prograamlo organel biologypy vibhaagaaniki adhipatigaa unnaaru. lippinkat-swartz zaan hopkins vishwavidyaalayam nundi Phd andukunnaru, mariyu maereelaandlooni nihlo richard clousenertho post-doctoral sikshananu nirvahinchaaru.
lippinkat-swartz yokka parisoedhana prakaram, eucariotic kanaala avayavalu dynamic, sweeya-vyavastheekruta nirmaanaalu, ivi sthiramaina nirmaanaala kante intracellular vesical traaphik dwara nirantaram tamanu taamu punarutpatti chesukuntaayi. kanaalalo anuvula dynamic paraspara charyalanu adhyayanam cheyadaaniki live sell imaging paddhatulanu abhivruddhi cheyadamlo kooda aame maargadarsakudu, veetilo photobleaching mariyu photoactivation paddhatulu unnaayi, ivi upa kana sthaanikeekarana, chalanasheelata, ravana margalu mariyu pora akrama ravana mariyu compartmentalisationcu sambandhinchina mukhyamaina cellular proteinla turnovernu parisoedhinchadaaniki anumatistaayi. lippinkat-swartz prayogasaala kinetic modeling mariyu anukarana prayogaala dwara parimaanaatmaka kolatalanu upayoginchadam dwara protein mariyu organel functionlu mariyu dynamicsku sambandhinchina yaantrika parikalpanalanu kooda pareekshistundi. craigg blaxtonetho paatu, lippinkat-swartz paridheeya endoplasmic reticulum elaa nirmanatmakamga undho marinta khachitamaina chitraanni velladinchadaaniki adhunaatana imaging paddhatulanu upayoginchindi. vaari parisoedhanalu endoplasmic reticulamnu roopondinchadamlo sahayapade proteinlanu prabhaavitam chese janyu vyaadhula kosam kotta antardrushtulanu ivvavacchu. adanamgaa, lippinkat-swartz yokka prayogasaala golgi enjaimlu endoplasmic reticulanku tirigi recycle chestayani mariyu ksheerada kanaalalo golgi upakaranam yokka nirvahana, jeevajanana mariyu vaarasatvamlo ituvanti recycling pradhana paatra pooshistundani niroopinchindi.
lippinkat-swartz prayogasaalalo, prastuta prajectulalo aneka kana jeevasambandha praantaalu unnaayi. udaaharanaku, protein ravana mariyu cytoskeleton paraspara charya, organel assembly mariyu disassembly, mariyu sell polarity generation. fluorescentga label cheyabadina proteinla dynamicsnu vislaeshimchae prajectulu kooda unnaayi. eee proteins fraap, fcs mariyu photoactivation vanti aneka live sell imaging paddhatulanu upayoginchi label cheyabadataayi.
lippinkat-swartz thana iteevali prayogasaala parisoedhananu photoactivation localization microscopy (paam) kii ankitam chesindi, idhi naano-scale vadda adhika saandratala paramaanu pampineelanu chuudataaniki anumatistundi.
prarambha jeevitam.
gennifer lippinkat-swartz aktobaru 19,1952naa consasloni manhatonlo janminchaaru. aame tandri maryland vishwavidhyaalayamlo bhouthika rasayana shaastra professorga unnaaru mariyu aame kutumba vantagadilo oka aavartana pattika vaelaadutuu kanipinchindi. lippinkat-swartz thana tandri paniki gurikavadam aame vignaana shaastram patla premanu rekettinchindi. aaa kutumbam uttara varjeeniyaaloni oka polaniki vellindi, akkada aneka gurralu mariyu vividha itara jantuvulu undevi. ikkade lippinkat-swartz jeevasaastram patla thana premanu kanugonnaru.
vidya.
lippinkat-swartz swarthmore kalasalalo chadivi, akkada aame manastatvasaastram mariyu tatvasaastramlo praaveenyam pondhi, 1974loe swarthmore kalaasaala nundi gowravaalatho pattabhadruraalaindi. aame americaku tirigi vacchi stanford vishwavidhyaalayamlo jeevasaastramlo masters prograamloki pravesinche mundu rendu samvatsaraalu kenyaalooni oka baalikala unnata paatasaalalo sains bodhinchindi, akkada aame phillip hanawalt prayogasaalalo dna marammattupai panichesindi. aaa tarvaata aame biochemistry Ph loe pravesinchindi.dii. zaan hopkins vishwavidhyaalayamlo programme, akkada aame carnegie institute off embriologylo douglus fombro yokka prayogasaalalo panichesindi mariyu lysosomal membrane proteinla dynamicsnu adhyayanam chesindi.
vrutti.
post doctoral pani.
1986loe zaan hopkins nundi pattabhadrudaina taruvaata, lippinkat-swartz richard dii. loe cheraadu. national institute off healthlo clousener lyab. pora akrama ravaanaanu addukovadaniki drugg brefeldin eah nuu upayoginchi, endoplasmic reticulum mariyu golgi madhya pora chakram undani aame choopinchindi, idhi cellular organellu dynamic, sweeya-vyavastheekruta nirmaanaalu anie gurtinchadaaniki daariteestundi, ivi nirantaram kanaantara vesikil traaphik dwara tamanu taamu punaruddharinchukuntaayi.
nih.
1990loe nih vadda lippinkat-swartz national institute off chiled health und human developmentlo staff phelo ayyadu. eee samayamlo, lippinkat-swartz jeeva kanaalalo cellular akrama ravana maargaalanu drushyamaanam cheyadaaniki green fluorescent protein (gfp) nuu upayoginche paddhatulanu abhivruddhi cheyadam praarambhinchindi. pora proteinla dynamics adhyayanam cheyadaaniki photobleaching (fraap) tarvaata fluorescence recovery tekniknu aame suddhi chesindi. eee paddhatiloo, gfp-tagg cheyabadina pora proteins kanamlooni oka chinna praantamloo photobleachingku lobadi untaayi, aapai bleach cheyani proteinlanu bleach cheyabadina vaatini bharti cheyadaaniki entha samayam padutundo telusukovadaaniki kanam chithreekarinchabadutundi, antey.ii. fluorescence kolukovadaniki entha samayam padutundi. eee paniki mundu, err, golgi mariyu plasma membrane vanti aargaanelloni membrane proteins aaa sthaanamlo sthiramgaa unnayani bhaavinchaaru. ayithe, kanam lopala anuvulu chaalaa vaegamgaa kadulutayani mariyu swechchagaa vyaapti chendagalavani fraap technic niroopinchindi. lippinkat-swartz taruvaata photoactivate cheyagala zii. eff. pii. nii pravesapettindi, idhi vikiranam tarvaata daani fluorescensenu penchutundi. idhi lippinkat-swartz mariyu aame post-dock georg patterson golgi dwara cargo anuvula ravaanaanu chaalaa khachitatvamto track cheyadaaniki anumatinchindi, idhi cargo ravana anedi kramabaddhamaina krama prakriya kaadani grahinchadaaniki daariteesindi; badulugaa, golgi yokka pratyeka pora stacklu oke nirantara nirmaanam, mariyu poralu dwara proteins vaegamgaa samatulyata chendutaayi.
photoactivate cheyagala zii. eff. pii. paie lippinkat-swartz chesina pani, howard hugs medical institute yokka janelia form research campus yokka eric betzigto sahakaaraaniki daariteesindi, dheenilo zii. eff. pii fluorescensenu aann mariyu off chese saamarthyaanni modati "suupar resolution imaging" saanketikatalalo okataina photoactivation localization microscopy (paam) nuu abhivruddhi cheyadaaniki upayoginchaaru. suupar-resulved fluorescence microscopy" abhivruddhini 2014loe vilium ii thoo paatu eric betzigku rasayana saastramlo nobel bahumati dwara gurtinchabadindi. stanford vishwavidyaalayam yokka morner, mariyu stephan doubleu. jeeva bhouthika rasayana shaastram kosam macs plank institute.
lippinkat-swartz stoichiometry mariyu membrane graahakaala kuurpunu anchanaa vaeyadaaniki arachetini upayoginchindi mariyu rendu-rangu arachetini abhivruddhi cheyadaaniki newyorkloni albert inestein college off medicine yokka vladislav verkhushaatho kalisi panichesindi. endoplasmic reticulum takkuva resolution vadda kanipinche sheetlaku badulugaa dattamaina gottapu maatrukato koodi undani choopinchadaaniki aame aidu suupar-resolution paddhatula kalayikanu upayoginchindi.
janelia parisoedhanaa kendram.
2016loe, lippinkat-swartz, janelialo neuronal sell biology prograamnu praarambhinchadaaniki howard hugs medical institute yokka janelia research campassku vellaaru.

