santati dwara gurtimpu

eee vibhaagamlo okela nucleotide shrenulu unte, rendu ledhaa anthakante ekkuva vyaktulalo dna vibhagam sthithi (ibs) dwara okela untundi. oka ibs vibhagam rendu ledhaa anthakante ekkuva vyaktulalo santati (ibd) dwara okela untundi, vaaru daanini punarekeekarana lekunda oka saadhaarana puurveekudi nundi vaarasatvamgaa pondinatlayithe, antey, eee vibhaagamlo eee vyaktulalo oke puurveekula muulam untundi. ibd ayina dna vibhagalu nirvachanam prakaram ibs, conny ibd kaani vibhagalu ippatikee ibs kaavacchu, endukante ververu vyaktulalo oke utparivartanalu ledhaa vibhaganni marchani punassamyojanaalu.
siddhaantam.
parimita janaabhaalooni vyaktulandaruu taginanta kaalam gurtinchinatlayite sambandham kaligi untaaru mariyu anduvalla, vaari janyuvula vibhaagaalanu panchukuntaaru. meosis samayamlo ibd yokka bhagalu punassamyojanam dwara vibhajinchabadataayi. anduvalla, oka ibd vibhagam yokka anchanaa podavu, aaa vibhagam yokka locus vadda atyanta iteevali saadhaarana puurveekudu nundi taraala sankhyapai aadharapadi untundi. gatamlo oka saadhaarana puurveekudu "n" taraala nundi vacchina IBD vibhagala podavu (anduvalla 2 "n" meosis kaligi untundi) sagatu 1/(2 "n") morganlatho (m) ghatankamga pampinhee cheyabadutundi. eee pradaesamloe saadhaarana puurveekula nundi taraala sankhyatho paatu ibd vibhagala sankhya taggutundi. oka nirdishta dna vibhaagaaniki, ibd ayye sambhaavyata 2−2 "enn" gaa taggutundi, endukante prati meosislo eee vibhaganni prasaram chese sambhaavyata 1/2.
applications.
gurtinchina ibd vibhaagaalanu vistruta shreni prayojanaala kosam upayoginchavacchu. paina paerkonnatlugaa ibd bhaagaswaamya mottam (podavu mariyu sankhya) pareekshinchina vyaktula madhya kutumba sambandhaalapai aadharapadi untundi. anduvalla, ibd segment detection yokka oka application sambandhitatanu lekkinchadam. sambandhita kolatanu forensic janyusaastramlo upayoginchavacchu, conny janyu anusandhaana mappinglo samacharanni kooda penchavacchu mariyu praamaanika anubandha adhyayanaalalo namodukani sambandhaala dwara pakshapaataanni tagginchadamlo sahaayapadutundi.
ibd yokka maroka anuvartanam janyuroopa prerana mariyu haplotype dasha anumanam. chinna praantaala dwara vibhajinchabadina ibd yokka podavaina bhagalu faging lopaalanu suuchimchavachchu.
ibd mapping.
ibd mapping anedi anusandhaana vislaeshanha maadirigaane untundi, conny sambandham laeni vyaktula samuuhampai telisina vamsapaaramparyata lekunda nirvahinchavacchu. ibd mappingnu anubandha vislaeshanha yokka kotta roopamgaa chudavachu, idhi aneka arudaina vyaadhi grahanaseelata vaividhyaalanu kaligi unna janyuvulu ledhaa janyu praantaalanu mapp chese saktini penchutundi.
anukarana daetaanu upayoginchi, braun mariyu thampson oka janyuvulo aneka arudaina vaividhyaalu vyaadhi grahanaseelataku dohadapadinappudu anubandha pareeksha kante ibd mapping adhika saktini kaligi undani choopinchindi. ibd mapping dwara, janyuvu-vistruta gananeeyamaina praantaalu vivikta janabhalo alaage bahya jaatula janabhalo kanugonabaddayi, ayithe praamaanika anubandha pareekshalu viphalamayyayi. houven mariyu itarulu. vivikta matsyakaara janabhalo nirapaayamaina punaraavruta intrahepatic collestassisku kaaranamayye janyuvu yokka chromosome sthaanaanni gurtinchadaaniki ibd bhagaswamyanni upayoginchaaru. kennie mariyu itarulu. plasma plant sterol (pps) sthaayila yokka janyuparamaina anubandha adhyayanam (zii. doubleu. ess) dwara kanugonabadina signalnu chakkaga mapp cheyadaaniki oka vivikta janabhanu kooda upayoginchaaru, idhi pregu nundi collustroll shoshana yokka surrogate kolata. franks mariyu itarulu. cases-controll namuunaala janyuroopa detatho schizophrenia mariyu bipolar desorder kosam sambhaavya grahanaseelata sthaanaanni gurtinchagaligindi. linn mariyu itarulu. multiple sclerosis rogula datasetlo janyuvu-vistruta mukhyamaina anusandhaana sanketaanni kanugonnaru. letouse mariyu itarulu. cancer namoonaalalo vyavasthaapaka utparivartanalanu chuudataaniki ibd mappingnu upayoginchaaru.
janabha janyusaastramlo ibd.
maanava janyuvulo sahaja empikanu gurtinchadam kooda gurtinchina ibd vibhagala dwara saadhyamavutundi. empika saadhaaranamgaa janabhalo vyaktulalo ibd vibhagala sankhyanu penchutundi. adhika ibd bhaagaswaamyamto unna praantaalanu scanning cheyadam dwara, maanava janyuvulooni praantaalu balamgaa unnaayi, chaalaa iteevali empikanu gurtinchavacchu.
daaniki adanamgaa, ibd vibhagalu janabha nirmaanampai itara prabhavalanu kolavadaniki mariyu gurtinchadaaniki upayogapadataayi. gusev mariyu itarulu. addamkulu mariyu mishramtho sahaa janabha charitranu anchanaa vaeyadaaniki adanapu modalingtho ibd vibhaagaalanu upayoginchavacchani choopinchindi. ilanti namuunaalanu palamara mariyu itarulanu upayoginchadam. mariyu kaarmi mariyu itarulu. ashkenazi yoodu mariyu kenyon masay vyaktula janabha charitranu punarnirminchaaru. botigu mariyu itarulu. european janabhalo african puurveekulaloo thedaalanu parisoedhimchaaru. vividha european janabha mariyu kankara modalaina vaati saadhaarana puurveekulanu lekkinchadaaniki ralf mariyu cope ibd detection upayoginchaaru. adevidhamgaa americaloni janabha yokka janyu charitrapai nirdhaaranalanu teesukoovadaaniki prayatninchaaru. ringbour mariyu itarulu. gatha sataabdaalaloo thoorpu airopalo chedaragottadaanni anchanaa vaeyadaaniki ibd vibhagala bhougolika nirmaanaanni upayoginchaaru. 1000 janyuvula daetaanu upayoginchi hockriter african, asea mariyu european janabha madhya ibd bhaagaswaamyamlo thedaalanu kanugonnaru, alaage ninderthal ledhaa denisova vanti puraatana janyuvulatho panchukune ibd vibhagalu kooda kanugonnaru.
paddhatulu mariyu software.
sambandham laeni vyaktulalo ibd vibhaagaalanu gurtinchadaaniki karyakramaluhu

