myophybroblast

myophybroblast anedi oka sell phenotype, idhi fibroblast mariyu mruduvaina kandaraala kanam madhya unna sthithilo unnatlu modata varninchabadindi.
nirmaanam.
myophybroblastlu anevi sanklishtamaina web lanty fusiform kanaalu, ivi vaati cytoplasmic stress fibers lopala α-smooth kandaraala actin yokka vyakteekarana dwara gurtinchabadataayi.
jeernasayaantara mariyu jananaaliiya margalalo, myophybroblastlu shleshma uparitalaalo upa-upaslaeshmamgaa kanipistaayi. ikkada avi guptapadaalu mariyu villeela aakaraanni niyantrinchevigaa matrame kakunda, pregula guptapadaalalo muula-nick kanaalugaa mariyu vilakshanhamaina antigen-presenting kanaala bhagaluga kooda panicheestaayi. avi chaalaa pradaesaalaloo maddatu mariyu paracrine function rendintinee kaligi untaayi.
sthaanam.
charma gaayam nayam avutunnappudu kanajaalamlo myophybroblastlanu modata gurtinchaaru. saadhaaranamgaa, eee kanaalu granulation kanajaalam, maccha kanajaalam (fibrosis) mariyu kanitula stromalo kanipistaayi. avi jeernasayaantara pregulanu kooda varusalo unchutaayi, indulo avi guptaalu mariyu villeela aakaralanu niyantristaayi.
markerlu.
myophybroblastlu saadhaaranamgaa madhyantara filament vimentin kosam marakalu, idhi saadhaarana messenchimal marker, α-smooth kandaraala actin (maanava janyuvu = sanghatanalu), mariyu palladine kosam, idhi cytoskelital actin paranjaanu protein. konni kanajaalaalo madhyantara filament rakam desmine vanti itara mruduvaina kandaraala gurtulaku avi sanukoolamgaa untaayi, conny itara kanajaalaalo desminku pratikuulamgaa undavacchu. metavinculin mariyu smoothelin vanti mudatalu laeni mruduvaina kandaraalalo matrame sanukoolamgaa unde konni tappa daadaapu prati mruduvaina kandaraala markerku ilanti bhinnamaina saanukuulata undavacchu.
myophybroblastlu fibroblastla nundi vaati bhedam samayamlo mariyu taruvaata fibronectin, kollaajenlu mariyu hyaluronic aamlam yokka vyakteekarananu niyantristaayi. veetilo, fibronectin (edaa-efn) yokka edaa isopharm, mariyu collagen rakam ii ii proo-fibrotic extracellular matricks yokka myophybroblast-aadhaarita samslaeshanha yokka vilakshanhamaina gurtulu.
konni myophybroblastlu (mukhyamgaa avi stellet roopaanni kaligi unte) kooda gfapki sanukoolamgaa undavacchu.
abhivruddhi.
myphybroblast abhivruddhiki aneka margalu unnaih
bahusha myophybroblast erpadataaniki atyanta adhyayanam cheyabadina maargam fibroblast kanaala nundi nundi aadhaarita vyatyaasam. tgf-beata receptor 1 mariyu tgf-beata receptor 2 yokka kriyaaseelata canonical smad 2/smad 3 marganni prerepinchadaaniki daariteestundi. canonical kaani ii. zii. eff. aarr maargam yokka saha-kriyaaseelatatoo kalisi, eee sanghatanalu sanghatanalu janyuvu yokka niyantranaku mariyu tadupari alfa smooth kandaraala actin protein utpattiki daariteestaayi. myophybroblast bhedam maargam yokka aneka niyantrakaalu vivarinchabaddaayi, veetilo haiyaluronan mariyu mariyu koo-receptor activation off egfr unnaayi.
function.
kaaleyam, oopiritittulu mariyu moothrapindaalu vanti aneka avayavaalalo, avi pradhanamgaa fibrosislo palgontayi. gaayam kanajaalamlo avi extracellular collagen fiber nikshepana dwara gaayam balopetam kaavadamlo chikkukuntaayi, aapai collagen kattalaku integrin-madhyavartitvam dwara collagen fibers yokka intracellular sankocham mariyu sahasamyojana amarika dwara gaayam sankocham. perisaitlu mariyu moothrapindaala messangeal kanaalu savarinchina myophybroblast lanty kanaalaku konni udaaharanalu.
myophybroblastlu gunde layanu niyantrinche vidyut sankethaala vyaaptiloo jokyam chesukovacchu, idhi gundepotuto badhapaduthunna rogulalo mariyu pindaalalo arithmiyaaku daariteestundi. eee paristhitiki ursodiol oka aasaajanakamaina aushadham.
gaayam nayam.
alfa-smooth kandaraala actin anie piluvabade actin roopamlo samruddhiga unde smooth kandaraala rakam actin-mayosin complexenu upayoginchadam dwara myophybroblastlu kudinchagalavu. eee kanaalu gaayam anchulanu kudinchadam dwara gaayam marammattunu vegavantam cheyagalavu.
gaayam nayam cheyadampai prarambha pani gaayam nundi teesukunna granulation kanajaalam mruduvaina kandaraalaku samaanamaina paddhatiloo "inn vitrolo" (ledhaa avayava snaanamlo) kudinchagaladani choopinchindi, adrenaline ledhaa angiotensin vanti mruduvaina kandaraala kudurchukovadaniki kaaranamayye padaarthaalaku gurainappudu.
iteevala fibroblastlu photobiomodulationtho myophybroblastluga maragalavani choopabadindi.
nayam ayina tarvaata, eee kanaalu apoptosis dwara kolpotayi mariyu aneka fibrotic vyaadhulalo (udaaharanaku liver syrrosis, moothrapindaala fibrosis, retroperitonial fibrosis) eee vidhanam panicheyadam ledani, idhi myophybroblastla sthirathvaaniki daariteestundani, tatphalitamgaa sankocham thoo extracellular matricks (fibrosis) vistaranaku daariteestundani soochinchabadindi.
adevidhamgaa, parishkarinchadamlo viphalamaina mariyu calloids ledhaa hypertrophic macchalugaa maare gayalalo, myophybroblastlu apoptosis dwara adrushyam kakunda konasaagavacchu.

