c9orf50

chromosome 9 open reeding frame 50 anedi maanavulalo "c9orf50" janyuvu dwara encode cheyabadina protein. protein maroka telisina maaruperu, flj35803 undhi. maanavulalo janyu coding kramam 10,051 bays jatala podavu untundi, idhi 431 amaino assid proteinnu encode chese 1,624 bays la yokka mrna nii lipyantareekaristundi.
janyuvu.
sthaanam.
maanavulalo janyuvu pratikuula tantuvu meeda 9q34.11 vadda untundi mariyu coding kramam 8,552 bays jatala podavu untundi. maanava chromosome chromosome, janyuvu c9orf50 sameepamlo "chr 9:132,374,504-132,383,055" bays lanu vistarinchi untundi, idhi pratikuula strandpy c9orf50 kii mundu unna janyuvu mariyu saanukuula strandpy nTMt1, idhi c9orf50 kante rettimpu kante ekkuva parimaanam kaligi untundi.]
protein.
c9orf50 protein 47,639 kd paramaanu baruvunu kaligi untundi mariyu 431 amaino aamlaalanu kaligi untundi, anchanaa vesina isoelectric point 10.38 thoo c9orf50 protein pfam15737-duf4685 loe samrakshinchabadina domaine kaligi untundi, dheeni paniteeru sakasherukaalalo baga ardham kaaledu mariyu samrakshinchabadaledu. protein 7 exanlatho tayaaravutundi.
isopharmlu.
utparivartanalu 9 ververu splies isopharmlu (Si) mariyu 11 ververu transcript vaeriyantlu (TV) unnaayi, veetilo atyanta saadhaaranamainadi isopharm 1 mariyu transcript variant 1.
domainlu.
proteinnu mottamgaa vislaeshimchavachchu alaage 193 avasheshaala enn-terminal domine, 103 avasheshaala dii mariyu 135 avasheshaala sii-terminal domaintho sahaa 3 bhagaluga vibhajinchavachhu. puurti protein paie anedi enn. tii. dii, dii mariyu sitidi yokka sagatu paini pooli untundi. eee vibhagalalo enn. tii. dii.
atyadhika paie mariyu emm. doubleu. conny 431 loe 193 vadda atyadhika avasheshaalanu kooda kaligi undhi.
kuurpu.
c9orf50 protein yokka kuurpu vislaeshanha manavulaku sambandhinchi i, m, y mariyu fikmony takkuva mottamlo mariyu adhika mottamlo r, mariyu kr-ed nuu velladistundi. chaarj clusterlu, adhika scoring chaarj ledhaa chaarj cheyani vibhagalu, chaarj parugulu, namuunaalu, adhika scoring hydrophobic ledhaa transmembrane vibhaagaalaku etuvanti phalitaalu laevu. 161, 190, mariyu 342 sthaanaalalo sii yokka moodu ververu pratyaekamaina antaraalu kanugonabaddayi. kanugonabaddayi kooda 3 punaraavruta nirmaanaalanu kaligi unnatlu kanugonabadindi, modati kramam prilp _ kilt 30 sthaanam nundi praarambhamai 78 sthaanam vadda punaraavrutamavutundi. maroka punaraavruta nirmaanam 99 mariyu 398 sthaanaalalo slp. 250 mariyu 303 vadda chivari punaraavruta nirmaanam kaaltho tayaaru cheyabadindi.
trutheeya nirmaanam.
trutheeya c9orf50 protein nirmaanaalanu i-tasser upayoginchi kanugonavacchu. eee sadhanam 5 visualized structures kii daariteestundi, atyadhika sii skorlu kaligina rendu-3.5 mariyu-1.27.
janyu sthaayi niyantrana.
prothsaahakulu.
c9orf50 kosam prothsaahaka praantam genomatics upayoginchi kanugonabadindi
kanugonabadindi promoter serch injin. dheeni phalitamgaa 6 pravartaka praantaalu erpaddaayi. veetilo 2 matrame transcripts mariyu panjaram tagla dwara maddatu ivvabaddaayi. atyanta maddatugala prothsaahaka praantam 1,962 sthaavaraalalo vistarinchi undhi mariyu 945 panjaram taglatho 8 orthologus lokilalo 6 loe samrakshinchabadindi. 118 panjaram taglatho maddatu ivvabadina 7 exanlatho transcript nundi transcription prarambha sait 1,503 vadda undaalani nirnayinchaaru.
transcription phyaaktar binding saitlu.
prothsaahaka praantaanni bandhinche vandalaadi transcription karakalu anchanaa veyabaddaayi. promoter region transcription factors table veetilo 20 amsaalanu highlight chestundi.
transcript sthaayi niyantrana.
c9orf50 5 'utr intermolecular bays jatha chesina nirmaanam atyadhika delta g thoo-323.4 kcal/mol. idhi 5 'utr praantaaniki anchanaa vesina athi takkuva shakti nirmaanam. 3 'utr kosam, atyadhika digi-127.5 kesili/moll, idhi 5' utr vale sthiramgaa ledani suuchistumdi. 
kanajaala vyakteekarana.
c9orf50 yokka rna-sec dayta anni maanava proteinlatho poliste chaalaa maanava kanajaalaalo takkuva vyakteekarana sthaayi, 25-50 va saataanni kanugondi. ayithe, idhi vrushanhaalu, medadu mariyu pittaasayam loe ekkuvagaa vyakteekarinchabadutundi. c9orf50 protein vyakteekarana c9orf50 rna vyakteekarana kante ekkuvagaa untundi. situ hybridisation daetaanu adhyayanam chesetappudu, mouse c9orf50 ortholog, gurthu 1700001o22rik, beata-actinku vyatiraekamgaa protein vyakteekarananu poolchadaaniki upayoginchabadindi, idhi sarvavyaaptamgaa vyakteekarinchabadutundi mariyu vislaeshanhalu eluka medadulo saaruupya vyakteekarana namuunaalanu chuuputaayi. abhivruddhi samayamlo, pindam dasalalo protein kanugonavacchu.
upakosha vyakteekarana.
protein pradhanamgaa kendrakamlo undhi mariyu mitochondria mariyu cytosollalo takkuvagaa kanipistundi. 
orthologs.
c9orf50 yokka telisina peraalaaglu laevu. 159 million samvatsaraala kritam vaeru cheyabadina infraclass marsupialia yokka atyanta dhoorapu, oposum thoo c9orf50 yokka orthologlu ksheeradaala yokka chaalaa upavargaalalo samrakshinchabaddaayi. eee janyuvu sareesrupaalu, ubhayacharaalu, pakshulu ledhaa ksheeradaalaku mundu udbhavinchina itara jeevulalo kanipinchadu. c9orf50 samrakshinchabadina ksheeradaala jabita krinda choopabadindi. 
parinaamam.
cytochrome sii, haemoglobin beata mariyu fibrinogen alfa chain vanti itara saadhaarana proteinla kante kante marinta vaegamgaa abhivruddhi chendutundani anchanaa veyabadindi. 
amaino aamlam samrakshana.
mukhyamaina amaino aamlalu kathinamaina artolog bahula kramam amarika yokka veekshanhalo srushtinchabadina 100% ekaabhipraaya rekhalo undevi. erupu rangulo unna amaino aamlalu aamlalu samrakshinchabadina amaino aamlaalanu suuchistaayi. 22 atyanta samrakshinchabadina amaino aamlalalo 14 eee domainlo kanipistaayi. kanipistaayi proteinlo atyanta samrakshinchabadina sthaanaalanu lucine aakramistundi.
utparivartanalu.
utparivartanalu saadhaarana vaividhyaalu ncbi ncbi kanugonabaddayi.

