
tnf receptor suupar family

tumour necrosis phyaaktar receptor suupar family (tnfrsf) anedi cytokine graahakaala protein suupar family, idhi kaniti necrosis kaarakaalanu (tnfs) extracellular systeine-ritch domine dwara bandhinche saamarthyam kaligi untundi. naraala perugudala karakam (ngf) minaha, anni tnf luu archetipal tnf-alfaku samanamga untaayi. vaati kriyaaseela roopamlo, ekkuva tnf grahakaalu plasma poralo trimeric complexelanu yerparustaayi. tadanugunamgaa, chaalaa tnf grahakaalu transmembrane domainlanu (tmd) kaligi untaayi, ayithe konnintini karige rupaluga vibhajinchavachhu (ii.zii. tnfr1), mariyu kontamandiki puurtigaa tmd ledhu (ii.zii. dcr3). adanamgaa, chaalaa tnf graahakaalaku diguva sankethaalu kosam trade, troff, rip mariyu phaad vanti nirdishta adaptor protein avasaram. tnf grahakaalu pradhanamgaa apoptosis mariyu vaapulo palgontayi, conny avi vistarana, manugada mariyu bhedam vanti itara signal transduction margalalo kooda paalgonavacchu. tnf grahakaalu ksheeradaalalo, mukhyamgaa leukocytelalo, aneka rakaala kanajaalaalo vyakteekarinchabadataayi.
deth receptor anae padam tnf receptor suupar familyloni sabhyulanu suuchistumdi, ivi deth domine kaligi untaayi, udaaharanaku tnfr1, phaas receptor, dr4 mariyu dr5. avi apoptosis (programme cheyabadina sell deth) loe mukhyamaina paatra pooshistunnatlu kanipinchina vaastavam paeru pettabaddayi, ayinappatikee avi ippudu itara paatralanu kooda poeshistaayi.
kathinamaina ardhamlo, tnf grahakam anae padaanni tarachugaa suupar family yokka architipal sabhyulanu suuchimchadaaniki upayogistaaru, avi tnfr1 mariyu tnfr2, ivi tnf-alphanu gurtistaayi.
sabhyulu.
27 mandhi kutumba sabhyulu unnaaru, sankhyaaparamgaa tnfrsf #gaa vargeekarinchabaddaaru, ikkada #anedi sabhyula sankhyanu suuchistumdi, konnisaarlu oka lekhanu anusaristundi.

