
epitopoitic research corporation

epitopoitic research corporation (erc) anedi belgium aushadha samstha, idhi arc1671 (brand paerlu gliovac, sitoiganap (iyu)) nuu abhivruddhi chestondi, idhi medadu cancer yokka atyanta dookudu roopam ayina glioblastoma multiform chikitsalo pratyekata kaligi undhi. 2019loe, yuu. ess. federal rait-tuu-trai chattam prakaram chikitsa andinchina modati aushadha samsthagaa arc nilichindi.
charitra.
apostolos stathopoulos lease vishwavidhyaalayamlo neurosurgery vidyaarthigaa unnappudu arc1671 yokka puttuka sambhavinchindi. oka shastrachikitsanu gamanistunnappudu, roogi kaniti yokka oka mukka athani kantiki taakindi. eee sanghatana stathopoulosnu aalochinchadaaniki mariyu athani shareera roganirodhaka vyavastha cancer kanaalanu naasanam chestundane aadhaaraalaku prerepinchindi.
2006.
stathopoulose elukalapai proof-off-concept adhyayananni nirvahistundi. perugutunna kanitulato elukalalo inject cheyabadina syngenic mariyu allogenic glioma kanaala kalayika parimaanaanni taggistundani mariyu ippatike unna kanitulanu nirmoolistundani mariyu kotta kanitulu erpadataanni nirodhistundani adhyayanam kanugondi. stathopoulos eee saanketikataku patent pondaadu mariyu manavulaku chikitsanu abhivruddhi cheyadaaniki arc nii kanugonnadu.
2009.
european medicines agency nundi gliovac/arc1671 kosam adhunaatana vaidya chikitsa utpatti hodaanu erc pondutundi. idhi proliferative tumourla kosam oka tissue byaanknu mariyu netherlandsloni shaizklo manchi tayari abhyasa-sammati utpatti sadupaayaanni srushtistundi.
2011.
gliovac us fda nundi anaadha aushadha hodaanu pondindi. peddavaarilo atyanta saadhaaranamaina mariyu praanaantakamaina medadu kaniti glioblastoma multiform, conny idhi USloe 10,000-17,000 mandini matrame prabhaavitam chestundi. nirvachanam prakaram, oka anatha vyaadhi samyukta rashtraallo 200,000 kante takkuva mandini prabhaavitam chestundi.
2012.
modati rogulaku dayagala upayogam anae siddhaantam kinda gliovac/arc1671 thoo chikitsa chestaaru. septembarulo, modati roogi puurti upasamanaaniki cherukunnadu.<reifer paeru = "doi 10.1016/j.vaccine.2015.03.095 "> </rifa>
2013.
gliovac/arc1671 yokka rendava dasha trials irvinlooni california vishwavidyaalayam bhaagaswaamyamto praarambhamavutaayi.
2018.
taatkaalika dasha II trial phalitaalu gliovac/arc1671 mariyu saadhaaranamgaa suuchimchina cancer nirodhaka aushadham bevasizumab (atavan) thoo chikitsa pondina rogulu bevasizumab thoo matrame chikitsa pondina vaari kante sagatuna daadaapu aidu nelala ekkuva kaalam jeevinchi unnaarani chuupistunnaayi.
2019.
roogi abhyardhana meraku, gliovac/arc1671 anedi trump paripalana aamodinchina yuu. ess. federal rait-tuu-trai chattam prakaram suuchimchabadina modati aushadham. samakhya chattam prakaram suuchimchabadinappatikii, chikitsa california rashtra hakku-pareeksha chattaala protokaallanu anusaristundi. arc anedi prayatninchagala rogulaku gliovaknu uchitam ledhaa takkuva kharchutho andubaatulo unchutundi.
2020.
erc sitoiganap brand paerutoe erc1671 kosam european medicines agency marketing application aatharaijeshannu samarpistundi. rendava trial sait haarvard yokka danna forber center pharr immuno-oncologylo praarambhamavutundi. gliovac saanketikata aadhaaramgaa kovidwak anae covid-19 vaccine abhivruddhini arc praarambhistundi.
naayakatvam.
apostolos stathopoulos (saha vyavasthaapakudu, ceo) belgiumlo sikshana pondina neurosurgeon. athanu greesloni ethensloni henry dunant aasupatrilo neurosurgery servies cheefga unnadu; wageningen vishwavidhyaalayamloni sell biology und immunology vibhaagamlo visiting professor mariyu dakshina california vishwavidhyaalayamloni keck school off medisinlo neurological surgery anubandha professor. ayana antarjaateeya immunotherapy cancer centarku saha-directorga panicheestunnaaru. us federal rait-tuu-trai chattaala krinda maargadarsaka chikitsa kosam, stathopoulosnu abigail kootami samvatsarapu maanavataavaadigaa perkondi.
thamus chenn (saha vyavasthaapakudu, sii. emm. oo) neurosurgeon mariyu university off sadaran california loe professor. vennemuka cancerpy drushti saarinchina kontamandi phelowship sikshana pondina vennemuka sarjanlalo ayana okaru. virgil skins (cheef scientific officer) european unionlo gliovac/arc1671 kosam namodu cheyabadina arhata kaligina vyakti. joseph elliot erk-yusa managing director, erk yokka us anubandha samstha.
utpattulu.
sitoiganap (iyu)/gliovac/arc1671 anedi roganirodhaka chikitsa teaca, idhi roogi yokka sonta kaniti nundi teesukunna kanaalanu upayoginchi, mugguru itara daatala nundi kaniti kanaalatoe paatu, glioblastoma (medadu kaniti) paie daadi cheyadaaniki shareera roganirodhaka vyavasthaku sikshana istundi. chaalaa teekaala maadirigaa kakunda, idhi roganirodhakamgaa kakunda, ippatike vyaadhini abhivruddhi chesina rogulaku matrame ivvabadutundi. ververu vyaktula nundi kaniti kanaalanu sweekarinchadam dwara, roogi yokka roganirodhaka vyavastha aneka ververu kaniti-sambandhita antigenlu (taa) ledhaa proteinlaku guravutundi, idhi kaniti kanaalu shareera rakshana nundi tappinchukune avakaasaanni taggistundi. eee vidhanam roogi kanitipai taa kii vyatiraekamgaa balamaina cytotoxic tii-lymphocyte (ctl, ledhaa "sell-killing" tii-sell) pratispandananu prerepistundani kooda nammutaaru. karunamaya viniyoga siddhaantam kinda chikitsa pondina tommidi mandhi rogula modati samuuhamloo, niyantrana samuuhamloo kevalam 33 saatam mandhi matrame aaru nelala paatu jeevinchi undagaa, 100% aaru nelala paatu jeevinchi unnaaru. niyantrana samuuhamloo 10 saatamtoe poliste, padhi nelallo 77 saatam mandhi praanaalatoe bayatapaddaru. arc1671 prastutam uslo rendava dasha trialslo undhi, alaage dayagala viniyoga protocols mariyu prayatninchadaaniki hakku chattaala krinda andubaatulo undhi. yuke yokka jaateeya aarogya seva yokka aavishkarana observatory prakaaram eee pratyeka teaca vidhaanaaniki antarleenamgaa unna mukhya suutram, chikitsa pondutunna roogi nundi matrame kakunda, mugguru swatantra gbm kanajaala daatala nundi chaerchadaaniki vistarinchina, tajaga vaeru cheyabadina mottam kaniti kanajaalam nundi utpannamaina vistruta kaniti antigenlanu upayoginchadam. eee bahula shreni autologus mariyu allogenic antigenlu roganirodhaka saktini kolpoye avakaasaanni taggistaayani bhaavistunnaaru, idhi antigenic nashtam ledhaa kriyaaseela pradhana hystocompatability complexes (emhechsi) down regulation nundi udbhavinchavacchu mariyu single-ledhaa parimita-antigen lakshya immunotherapyni upayogistunnappudu sambhavinche avakaasam undhi. eee chikitsa yokka bhavishyat vaagdaanam dheenini bevasijumabto mariyu roganirodhaka checkpoint inhibitorsto kalipe saamardhyamlo kooda undavacchu-idhi paridheeyamlo marinta saktivantamaina roganirodhaka kriyaaseelatanu alaage marinta dookudugaa unde sthaanika kaniti roganirodhaka lakshyeekarana mariyu vidhvamsamnu anumatinche empika.
april 2020loe, arc 1671 antarleena saanketikata aadhaaramgaa covid-19 kosam teaca ayina kovidwak paie abhivruddhini praarambhinchindi.