
lapcopm4bii

lysosomal-sambandhita transmembrane protein 4bii anedi maanavulalo "LLCPm4b" janyuvu dwara encode cheyabadina protein.
lapcom4bii protein oka lysosome sthaanikeekarana muulaamsaanni kaligi untundi mariyu chivari endosomelu mariyu lysosomlapy sthaanikeekaristundi.
clinical praamukhyata.
rommu, kaaleyam, oopiritittulu, andaasaya, garbhasaya, gastric cancerlalo L. P. P. M. 4b yokka perigina vyakteekarana kanugonabadindi. perigina lapcopm4bii sthaayi rommu cancerlo chemotherapy nirodhakataku dohadam chestundi. LLCPm4b yokka atigaa vyakteekarana anedi cytoplasmlo aushadhaanni nilupukovadam dwara mariyu aushadham mariyu aushadham prerita DNA nashtam yokka nuclear sthaanikeekarananu tagginchadam dwara anthracyclines (doxorubicin, dounorubicin mariyu epirubisin) nirodhakataku kaaranamavutundi.
lapcom4bii autofagini kooda prothsahistundi, idhi lysosomla madhyavartitvam vahistunna kana manugada yantraangam. lapcom4bii autofagini prothsahistundi mariyu kaniti kanaalanu jeevakriya mariyu genotoxic ottidiki nirodhakatanu andistundi mariyu marinta vaegamgaa kaniti perugudalaku daariteestundi. eee phalitaala aadhaaramgaa, chemotherapy nirodhakatanu nivaarinchadaaniki oka chikitsa lakshyamgaa ledhaa anthracyclines nundi prayojanam pondani rogulanu gurtinchadaaniki oka markerga L. P. P. m. 4b nii upayoginchavacchu.
epidermal groth phyaaktar receptor (ii. zii. eff. aarr) dwara cancer anukuula vidhulanu madhyavartitvam chestundi, idhi aneka ghana kanitulalo baga telisina ankogene atigaa vyakteekarinchabadindi mariyu/ledhaa utparivartana chendindi. poeshakaalu samruddhiga unna paristhitulalo, L. P. P. m. 4b anedi intraluminal sarting mariyu activated Egfr yokka lysosomal ksheenatanu nirodhinchadam dwara Egfr signalingnu vistaristundi. poeshakaalu lekapovadam vanti ottidiki guraina paristhitulalo, lapcm4bii pratyamnaayamgaa endosomal complexes vadda kriyaarahitamaina egfrnu vaeru chestundi, idhi autofagi appregulationku dohadam chestundi, idhi egfr tyrosine kines kaaryaacharana nundi swatantramaina pani. seeram aakali dwara gananeeyamgaa prothsahinchabadina kriyaarahita egfr thoo empikalatho lapcm4bii sankarshana chendutundi. anduvalla, LLCPm4b vistarana sankethaalanu penchadame kakunda, idhi cellular ottidi nirodhakatanu kooda penchutundi. eee adhyayanalu L. A. P. M. 4b ledhaa autofaguitoo saha-lakshyeekarana Egfr anedi Egfr positive cancer rogulalo chikitsa pratispandananu meruguparustundani suuchistunnaayi. 

