
phytosterol

phytosterols anevi collustroll maadirigaane unde phytosteroids, ivi mokkala jeeva pora yokka nirmaana bhagaluga panicheestaayi. avi mokkala sterols mariyu stanalsnu kaligi untaayi. 250 kante ekkuva sterols mariyu sambandhita sammelanaalu gurtinchabaddaayi. noonela nundi sekarinchina uchita phytosterols neetilo karaganivi, noonelo saapekshamgaa karaganivi mariyu alkahallalo karigevi.
phytosterol-samruddhiga unde aaharaalu mariyu aahara padaardhaalu dasabdaluga vikrayinchabadutunnaayi. phytosterols deerghakaalika viniyogam valla ldl collustroll-tagginche prabhavalu baga namodu cheyabadinappatiki, hridaya sambandha vyaadhulu, upavaasa raktamlo chakkera, glycated haemoglobin ledhaa mottam maranaala retupai prabhaavaaniki tagina aadharalu laevu.
nirmaanam.
avi fused polycyclic nirmaanaanni kaligi untaayi mariyu carbon side chains mariyu/ledhaa double baand (santruptata) uniki ledhaa lekapovadam loe maarutuu untaayi. carbon-4 sthaanam vadda methyl samuuhaala sthaanam aadhaaramgaa avi 4,4-dimethyl phytosterols, 4-monomethyl phytosterols mariyu 4-desmithyl phytosterolsga vibhajinchabaddaayi. stanols anevi santrupta sterols, ivi sterol ring nirmaanamloo dwandwa bandhaalanu kaligi undavu.
artical ledlooni anuvu β-sitosterol. paeru kudivaipuna choopabadindi.
adanamgaah
dietary phytosterols.
sahajamgaa labhinche phytosterols yokka atyanta sampannamaina vanarulu kuuragaayala noonelu mariyu vaati nundi tayaaraina utpattulu. sterols uchita roopamlo mariyu kovvu aamlam estarlu mariyu glycolypidluga undavacchu. bandhinchabadina roopam saadhaaranamgaa chinna pregulalo pancreatic enjaimla dwara jalavisleshanam cheyabadutundi. konni sterols suddhi noonelu mariyu kovvula yokka durgandha tolagimpu dasalo, vaati saapeksha kuurpunu marchakunda tolaginchabadataayi. anduvalla praamaanikatanu tanikhi cheyadamlo sterols upayogakaramaina sadhanam.
phytosterols yokka saadhaarana vanarulugaa, kuuragaayala noonelu phytosterol kantentnu highlight chese margareen utpattulugaa abhivruddhi cheyabaddaayi. phytosterols antagaa laeni trunadhaanyaalu, kuuragaayalu, pandlu mariyu berrylu kooda phytosterols yokka mukhyamaina vanarulugaa undavacchu, endukante vaati adhika viniyogam kaaranamgaa.
sahajamgaa sambhavinche phytosterols teesukovadam aaharapu alavaatlanu batti ~ 200-300 mg/roeju madhya untundi. pratyaekamgaa roopondinchina saakaahaara prayogaatmaka aaharaalu rojuku 700 mii. graa. kante ekkuva digubadini istayi. maanava aahaaramlo saadhaaranamgaa sambhavinche phytosterols beata-sitosterol, campestroll mariyu stigg master, ivi varusaga 65 saatam, 30 saatam mariyu 3 saatam aahara padaarthaalaku kaaranamavutaayi. maanava aahaaramlo atyanta saadhaarana mokka "stanols" sitostanol mariyu campestanol, ivi kalipi aahara phytosterallo 5 saatam varaku untaayi.
aarogya firyadulu.
effsae.
european phud safety authority (efsa) oka vyakti rojuku 1.5 nundi 2.4 graamula mokkala sterols mariyu stanalsnu teesukunte rakta collestraalnu sagatuna 7 nundi 10.5% varaku tagginchavacchani nirdhaarinchindi, eee prabhavam saadhaaranamgaa 2 nundi 3 varalalo sthaapinchabadutundi. 85 vaaraala varaku konasagina deerghakaalika adhyayanalu collustroll-tagginche prabhavanni konasaginchavacchani choopinchaayi. eee mariyu itara samarthatha dayta aadhaaramgaa, efsa shaastreeya panel eee krindi aarogya salahalanu andinchindihi "mokkala sterols rakta collestraalnu tagginchadaaniki/tagginchadaaniki chuupimchabaddaayi. raktamlo collestraalnu tagginchadam valla coronary haart disease vachhe pramaadaanni tagginchavachhu ".
eff. dii. eah.
phytosterols kosam eee krindi vaadananu fda aamodinchindih "plant sterol esterla kosam": (i) plant sterol esterla sevalaku kaneesam 0.65 graamulu kaligina aaharaalu, rojuku rendusaarlu bhojanamtho paatu kaneesam 1.3 graamula rojuvaaree mottam teesukovadam kosam, santrupta kovvu mariyu collustroll takkuvagaa unna aahaaramlo bhaagamgaa, gunde jabbula pramaadaanni tagginchavachhu. [aaharam paeru] yokka seva _ _ _ graamula kuuragaayala noone sterol estarlu sarafara chestundi. "mokkala stanal esterla kosam": (i) mokkala stanal esterla sevalaku kaneesam 1.7 graamulu kaligina aaharaalu, kaneesam 3.4 graamula mottam rojuvaaree teesukovadam kosam bhojanamtho rojuku rendusaarlu tinadam, santrupta kovvu mariyu collustroll takkuvagaa unna aahaaramlo bhaagamgaa, gunde jabbula pramaadaanni tagginchavachhu. [aaharam paeru] yokka seva _ _ _ graamula mokkala stanal estarlu sarafara chestundi.
phytosterol supplementho kuudina clinical trialsnu sameekshinchina fda, susampannamaina aaharalalo 1 nundi 3 graamula paridhiloo teesukunnappudu, phytosterols phalitamgaa placeboku sambandhinchi raktamlo ldl collustroll sthaayilalo ganankaparamga gananeeyamaina (5-15%) taggudala sambhavinchindani nirdhaarinchindi. phytosterol viniyogam mariyu collustroll taggimpu madhya sambandhaanni pradarsinchadaaniki rojuku 2 graamula phytosterols (naan-esterified phytosterolsga vyakteekarinchabadindi) rojuvaaree aahara teesukovadam avasaramani fda nirdhaarinchindi.
aarogya kenada.
1994 mariyu 2007 madhya phytosterol supplementho kuudina prachurinchabadina 84 yaadruchchika niyantrita pareekshala aadhaaraalanu health kenada sameekshinchindi. rojuku 2 graamula sagatu teesukovadam dwara ldl-collustroll sagatuna 8.8 saatam taggudala gamaninchabadindi. phytosterol viniyogam mariyu rakta collustroll taggimpu madhya sambandhaaniki maddatu ivvadaaniki tagina shaastreeya aadharalu unnayani aarogya kenada teelchindi. eee sakshyam aadhaaramgaa, hyper collusterolemic vyaktula kosam uddesinchina arhata kaligina aaharaala kosam aarogya kenada eee krindi prakatanalanu aamodinchindih
praathamika prakatanah
"[utpattiki paeru pettadam] yokka [metrik mariyu saadhaarana gruha kolatalalo poeshakaahaara vaastavaala pattika nundi parimaanaanni andinchadam] peddavaarilo collestraalnu tagginchadaaniki/tagginchadaaniki sahaayapadutundani chuupina rojuvaaree mottamlo * mokkala sterols x% andistundi."
madhyavartitvam chese mudrinchina, vraatapuurvaka ledhaa graphic material lekunda, praadhamika prakatana prakkane, kalayikalo ledhaa ontarigaa upayoginchagala rendu adanapu prakatanalu
"mokkala sterols collestraalnu tagginchadaaniki [ledhaa tagginchadaaniki] sahaayapadataayi."eee prakatana upayoginchinappudu, praathamika prakatana kante rendu retlu parimaanam mariyu praamukhyata varaku aksharaalalo choopabadutundi.
"adhika collustroll anedi gunde jabbulaku pramaada karakam."eee prakatana upayoginchinappudu, praathamika prakatana yokka adhe parimaanam mariyu praamukhyata varaku aksharaalalo choopabadutundi.
collustroll taggistundi.
collustroll sthaayilanu tagginche phytosterols saamarthyam modatisaarigaa 1953loe maanavulalo pradarsinchabadindi. 1954 nundi 1982 varaku, phytosterols taruvaata perigina collustroll chikitsagaa cytelline anae paerutoe aushadhamgaa vikrayinchabaddaayi.
collustroll tagginchadam valla hridaya sambandha vyaadhulu (sii. vii. dii) mariyu mottam maranaala pramaadaanni baga nirvachinchabadina paristhitulalo taggistundani niroopinchabadina stattins maadirigaa kakunda, phytosterol-susampannamaina aaharaalu ledhaa supplementlaku sii. vii. dii pramaadaanni tagginchadaaniki aadharalu asthiramgaa unnaayi, rendu sameekshalu collustroll-tagginche prabhavanni saadhinchadaaniki aahara phytosterols vaadakaaniki aadhaaraalanu chuuputaayi.
phytosterol-susampannamaina aahaaraalato statinsnu saha nirvahana cheyadam valla phytosterols yokka collustroll-tagginche prabhavanni penchutundi, mallii clinical prayojanaaniki etuvanti rujuvu lekunda mariyu sambhaavya pratikuula prabhaavaalaku sambandhinchina vruttaanta aadhaaraalatho. raetu-parimiti hchng-cova reductase enjaimnu nirodhinchadam dwara collustroll samshlaeshanhanu tagginchadam dwara stattins panicheestaayi. phytosterols okati ledhaa aneka saadhyamayye vidhaanaala dwara pegulo collustroll shoshanhatho pootii padatam dwara collustroll sthaayilanu taggistaayi, idhi statinsnu puurti chese prabhavam. phytosterols statin viniyogadaarulalo collustroll sthaayilanu 9 saatam nundi 17 saatam varaku taggistaayi. statin rakam ledhaa motaadu phytosterols yokka collustroll-tagginche saamarthyaanni prabhaavitam cheyadu.
collustroll tagginche lakshanaala kaaranamgaa, kontamandi tayaareedaarulu sterols ledhaa stanalsnu aahara sankalitamgaa upayogistunnaru.
bhadrata.
1954 nundi 1982 varaku samyukta rashtraalalo vikrayinchabadina phytosterols yokka aushadha tayari cytellin nundi phytosterols surakshitamaina upayogam yokka sudeergha charitranu kaligi unnaayi. phytosterol estarlu saadhaaranamgaa samyukta rashtraalalo surakshitamaina (grass) hodaagaa gurtinchabaddaayi. 2000loe european union marketloki pravesapettina tarvaata phytosterol kaligina kriyaatmaka aaharaalu prayogaanantara paryaveekshanhaku lobadi unnaayi, mariyu oohinchani dushprabhaavaalu nivedinchabadaledu.
phytosterol viniyogaaniki sambandhinchi sambhaavya bhadrata aandolana phytosterolamia unna rogulalo undhi, idhi arudaina janyu rugmata, dheeni phalitamgaa rakta mokkala sterol sthaayilu 50 nundi 100 retlu perugutaayi mariyu coronary atherosclerosis yokka vegavantamaina abhivruddhitho mudipadi untundi. phytosterolamia anedi abcg5/zii8 proteinlalo utparivartanaalato mudipadi undhi, ivi mokkala sterolsnu enterocytelu mariyu hepatocytela nundi varusaga lumen mariyu pitta naalaalaloki pamputaayi. raktamlo mokkala sterol sthaayilu sanukoolamgaa, pratikuulamgaa ledhaa sii. vii. dii pramaadamtoe sambandham laenivigaa chuupimchabaddaayi, idhi adhyayanam chesina janabhanu batti untundi.
mokkala sterols mariyu sii. vii. dii ledhaa sii. hetch. dii pramaadaala madhya sambandham sanklishtamgaa untundi endukante phytosterol sthaayilu collustroll shoshananu pratibimbistaayi. (collustroll shoshanaku gurthugaa phytosterols chudandi).
sterol verses stanal.
collestraalnu tagginchadaaniki mokkala sterols mariyu mokkala stanals yokka samaana saamarthyam mariyu bhadrata anedi teevramaina charchaneeyaamsamgaa konasagutondi. clinical trialslo mokkala sterols mariyu stanalsnu talakindulugaa polchinappudu, collustroll sthaayilanu samanamga taggistundani telindi. rojuku 0.6 nundi 2.5 graamula motaadulo neerugaa mokkala sterolsnu mokkala sterolsto polchina 14 yaadruchchika, niyantrita pareekshala meta-vislaeshanha mottam collustroll, ldl collustroll, hcdl collustroll ledhaa triglyzaride sthaayilapai rendu roopaala madhya etuvanti vyatyaasaanni choopinchaledu. mokkala sterols ledhaa stanals yokka adhika motaadulanu (rojuku 4 graamulu kante ekkuva) chuse trials chaalaa parimitam, mariyu mokkala sterol yokka adhe adhika motaadunu mokkala stanaltho polchadam inca puurti kaaledu.
sterol verses sterol gurinchi charcha. stanol bhadrata vaati ververu pregu shoshana mariyu phalitamgaa plasma saandratalapai kendrikrutamai untundi. phytosterols kante phytosterols takkuva pregu shoshana retunu (0.02-0.3%) kaligi untaayi, tatphalitamgaa raktamlo phytosterol gaadata saadhaaranamgaa phytosterol gaadata kante takkuvagaa untundi.
parisoedhana.
oopiritittulu, kadupu, andaasaya mariyu rommu cancerlatho paatu peddapregu mariyu prostate cancerlanu nirodhinche saamarthyam kosam phytosterols praathamika parisoedhanaloo unnaayi.
mokkalalo pani.
anni eukariotlaku sterols avasaram. oke oka pradhana sterolnu kaligi unna janthu mariyu shilindhra kanaalaku viruddhamgaa, mokkala kanaalu sterol mishramaala shrenini samslaeshanha chestaayi, indulo sitosterol mariyu stigmasterol prabalamgaa untaayi. sitosterol ksheerada kana porallo collustroll maadirigaane pora draavakata mariyu paaragamyatanu niyantristundi. mokkala sterols pora-kattubadi unde enjaimla karyakalapalanu kooda savarinchagalavu. phytosterols ushnogrataku mokkala anusarana mariyu vyadhikaaraka kaarakaalaku vyatiraekamgaa mokkala roganirodhaka saktitoe kooda mudipadi untaayi.

