
bufarmin

bufarmin (1-beautilbiguanide) anedi metformin mariyu fenforminlaku rasaayanikamgaa sambandhinchina biguanide taragatiki chendina noti dwara vachhe madhumeham nirodhaka aushadham. bufarmin nuu german aushadha samstha grunenthal silubin gaa vikrayinchindi.
rasayana shaastram mariyu janthu vishashaastram.
bufarmin hydrochloride anedi oka suukshmamaina, telupu nundi koddigaa pasupu, spatikaakaara, vaasana laeni podi, balaheenamaina aamla chedhu ruchitho untundi. dheeni draveebhavana sthaanam 174 nundi 177 masim, idhi oka balamaina punaadi, mariyu neeru, mithanol mariyu ithanaallo swechchagaa karugutundi, conny chloroform mariyu eetharlo karaganidi. vishapuuritam ginia pig eldi50 subcutaneous 18 mii. graa/kejee; mouse eldi50 intraperitonial 140 mii. graa/kejee mariyu 300 mii. graa/kejee noti dwara. logg octainol-water vibhajana gunakam (logg p)-1.20e + 00; daani neetilo karige saamarthyam 25 °C vadda 7.46e + 05 mg/l. aaviri peedanam 25°sii (esty) vadda 1.64e-04 mm hechji; henry yokka chattam sthiraamkam 25°sii (esty) vadda 8.14e-16 atm-emm3/moll. daani vaataavarana-oh raetu sthiraamkam 25 masim vadda 1.60e-10 cm3/anuvu-sekanu.
charya yokka yantraangam.
burmin jeernasayaantara pregu nundi glucose shoshananu alasyam chestundi, insulin sunnitatvaanni mariyu kanaalaloki glucose teesukoovadaanni penchutundi mariyu kaaleyam dwara glucose samshlaeshanhanu nirodhistundi. bufarmin mariyu itara biguanidelu hypoglycemic kaadu, conny antihyperglycemic agentlu. avi hypoglycemianu utpatti cheyavu; badulugaa, avi madhumeham rogulalo besal mariyu postprandial hyperglycemianu taggistaayi. biguanides glucagon charyanu vyatirekinchavachhu, tadwara upavaasam glucose sthaayilanu tagginchavachhu.
pharmacokinetics.
swachchanda sevakulaku 50 mii. graa. bufarmin noti dwara icchina taruvaata, moothramlo upayoginchina parimaanamlo daadaapu 90 saatam tirigi pondabadindi; tolagimpu raetu sthiraamkam gantaku 0.38 gaa kanugonabadindi. bufarmin oka balamaina punaadi (pica = 11.3) mariyu kadupulo grahinchabadadu. sumaru 1 mg/kilola bufarmin-14-c yokka intravenous injection tarvaata, prarambha seeram saandrata 0.2-0.4 μg/ml. seeram sthaayi mariyu moothra tolagimpu raetu saralamgaa paraspara sambandham kaligi untaayi. manishilo, 50 mg 14-c-bufarmin noti dwara icchina taruvaata, seeram yokka garishta saandrata 0.26-0.41 mg/ml. bufarmin sagatu sagam jeevitakaalam 2 gantalatho tolaginchabadindi. icchina motaadulo daadaapu 84 saatam moothramlo marakunda visarjinchinatlu kanugonabadindi. bufarmin maanavulalo jeevakriya cheyabadadu. noti dwara baformin mariyu itara biguanidela yokka jeeva labhyata 40%-60%. plasma proteinlatho bandham lekapovadam ledhaa chaalaa takkuvagaa untundi.
motaadu.
bufarmin yokka rojuvaaree motaadu noti dwara 150-300 mg. silubin retard anae sthiramaina vidudala tayaareeloo kooda bufarmin andubaatulo undhi, idhi ippatikee romanialo vikrayinchabadutundi.
dushprabhaavaalu mariyu vyatiraeka suuchanalu.
anorexia, vikaram, virechanaalu, lohapu ruchi mariyu baruvu taggadam vanti dushprabhaavaalu edurkontunnaayi. daani upayogam viruddhamgaa untundi
diabetic coma, ketoasidosis, teevramaina sankramana, gaayam, hyperglycemianu niyantrinche avakaasam laeni itara paristhitulu, moothrapindaala ledhaa hepatic balaheenata, gunde vaiphalyam, iteevali myocardial infract, nirjaleekaranam, madyapaanam mariyu lactic acidosisku gurayye avakaasam unna paristhitulu.
vishapuuritam.
lactic acidosis kaliginche pramaadam ekkuvagaa unnanduna (us loe kakapoyina, adhi eppuduu vikrayinchabadani chota) aneka deshaalalo bufarmin market nundi upasamharinchabadindi. bufarmin ippatikee andubaatulo undhi mariyu romenia (samayaanukuula vidudala syllabin retard gentiva dwara vikrayinchabadutundi), hangari, taiwan mariyu japan (nichi-aiko pharmaceutical koo dwara vikrayinchabadutundi., prati okkati 50 mg bufarmin hydrochloride kaligi unna "diabetos" maatralugaa). lactic acidosis anedi 0.60 microgram/ml kante ekkuva bufarmin plasma sthaayi unna rogulalo matrame sambhavinchindi mariyu saadhaarana moothrapindaala paniteeru unna rogulalo arudugaa sambhavinchindi.
oka nivedikalo, buforminpy lactic acidosisnu abhivruddhi chesina 24 mandhi rogulalo vishapuurita noti motaadu 329 ± 30 mg/roeju. rojuku 258 ± 25 mg unna 24 mandhi rogula maroka samuuhamloo buforminpy lactic acidosis abhivruddhi chendaledu.
cancer nirodhaka lakshanaalu.
bufarmin, fenformin mariyu metformin thoo paatu, cancer perugudala mariyu abhivruddhini nirodhistundi. eee aushadhaala cancer nirodhaka lakshanam warberg prabhaavaaniki antaraayam kaliginche saamarthyam mariyu cancer kanaala yokka cytosolic glycolysis lakshanaanni mitochondria dwara pairuvet yokka saadhaarana aakseekaranaku tirigi ichhe saamarthyam kaaranamgaa untundi. metformin madhumeham rogulalo kaaleyamlo glucose utpattini taggistundi mariyu emm. tii. aarr marganni aampike kriyaaseelata mariyu nirodhinchadam dwara cancerlo warberg prabhaavaaniki antaraayam kaligistundi. bufarmin rasaayanikamgaa prerepinchabadina eluka ksheerada cancerlo cancer sambhavam, bahulatvam mariyu bharanni tagginchindi, ayithe metformin mariyu fenformin niyantrana samuuhaaniki sambandhinchi carcinogenic prakriyapai ganankaparamga gananeeyamaina prabhavanni chuupaleedu. bufarmin endometrial cancer kanaalu, oopiritittula cancer kanaalu mariyu garbhasaya cancer kanaalalo anty-proliferative mariyu anty-invasive prabhavalanu kooda pradarsistundi.
antiviral lakshanaalu.
1940laloe influenzaaku vyatiraekamgaa biguanides churukuga unnatlu modatisaarigaa gurtinchabadindi. tadupari adhyayanalu vitrolo vaari antiviral charyanu dhruvikarinchayi. bufarmin, mukhyamgaa, vaccinia mariyu influenzaaku vyatiraekamgaa saktivantamaina antiviral. bufarmin anedi jeevakriya antiviral, idhi influenzae mariyu middle eest respiratory syndrome-sambandhita coronavirus upayoginche emm. tii. aarr marganni nirodhistundi.
charitra.
bufarmin 1957loe noti dwara vachhe anty diabeticga samslaeshanha cheyabadindi.
samslaeshanha.
beautilamine mariyu 2-sinoguanidine praticharya dwara bufarmin pondabadutundi.

