
maikhel gray

maikhel gray oka american neuro scientist mariyu alabama birmingham vishwavidhyaalayamlo neurology mariyu neurobiologyki assistant professor. gray anedi huntington vyaadhi (hetch. dii) yokka jeevasambandhamaina aadharam yokka adhyayanamlo parisoedhakudu. aame post doctoral paniloo, aame bachd anae transgenic mouse line abhivruddhi chesindi, idhi ippudu prapanchavyaaptamgaa hetch. dii. adhyayanamlo upayoginchabadutondi. gray yokka parisoedhana ippudu hetch. dii loe glial kanaala paatrapai drushti pedutundi. 2020loe sell press dwara americaloni 100 mandhi sphuurtidaayakamaina nallajati saastravettalalo gray okarugaa empikayyaadu. aame vamsapaaramparya vyaadhi foundation yokka shaastreeya bordulo sabhyuralu kooda.
prarambha jeevitam mariyu vidya.
gray paschima madhya alabamalo janminchaadu mariyu graameena samaajamlo perigaadu. aame graameena pempakam aamelo janthu jeevitam patla premanu prerepinchindi mariyu jeevasaastramlo under graduate degreeni konasaaginchadaaniki aamenu prerepinchindi. 1993loe gray, alabaamaaloni montgomeriloni alabama state universitylo kalaasaalanu praarambhinchindi. aneka jaateeya aarogya nidhulatho kuudina samsthala kaaryakramaala dwara, gray asulo mariyu vesavilo wisconsin madison vishwavidhyaalayamlo parisoedhanaloo palgonnadu. minority biomedical research support grant mariyu research kereer prograamku minority access maddatu, under graduate aame parisoedhana anubhavalu, vidyavetta anie dhruveekarinchadaaniki veelu kalpinchaayi.
1997loe bachelor off sainslo pattabhadruraalaina taruvaata, gray ohiyoloni columbus looni ohiyo state universitylo graduate sikshana pondadam dwara parisoedhana patla thana abhiruchini anusarinchindi. gbrafishlo naadii vyavastha abhivruddhini adhyayanam chestu molecular, cellular mariyu development biology vibhaagamlo christin beaty maargadarsakatvamlo gray sikshana pondindi. aame prayogasaalalo modati graduate vidyaarthi mariyu eff 31 national institute off health grant dwara nidhulu samakuurchabadindi. praanaantakamaina seven/naach1eah janyuvulo utparivartanala kaaranamgaa mouthner neuronla supernumary abhivruddhini aame anveshinchindi. utparivartana phalitamgaa erpade adanapu neuronlu gbrafishlo tappinchukune pravartanaku keelakamaina neural circuitlo chaerchabadataayani aame kanugondi. neuronlu tama bhoobhaganni vibhajistaayi kabatti, puraatana escape response neural circuitla yokka plasticity ledhaa vistarana ksheeradaalalo marinta sanklishtamaina escape neural circuitlaku maargam sugamam chesi undavacchani idhi suuchistumdi.
2003loe thana PhD puurti chesina taruvaata, gray california, laas angelsloni california vishwavidhyaalayamlo thana post doctoral panini puurti cheyadaaniki californiaku vellaaru. x maargadarsakatvamlo. vilium yang, gray thana adhyayana drushtini neurodegenerative vyaadhulaku, mukhyamgaa huntington vyaadhiki maarchindi. buudida rangu hetch. dii kosam oka kotta mouse modal abhivruddhiki maargadarsakatvam vahinchindi, idhi ippudu prapanchavyaaptamgaa upayoginche hetch. dii kosam pradhana mouse modal.
prayogasaalalo buudida rangu yokka modati prajectulalo okati janyuparamgaa nirvachinchabadina kana janabhanu kramabaddheekarinchadaaniki mariyu gurtinchadaaniki oka kotta paddhatini abhivruddhi cheyadaaniki oka brundamtho kalisi panicheyadam. aame janyuparamgaa label cheyabadina neuronlaku fluorescence activated sell sarting (facelu) nuu vartimpajesi, aapai vaati janyu vyakteekarana profilenu vargeekarinchindi. vaaru rendu upa rakaala besal neuronlalo vibhinnamgaa vyakteekarinchabadina janyuvula kotta samitini gurtinchaaru, mariyu hdloe chikkukunna striatonigral neuronla bhedaaniki ebf1 yokka vyakteekarana keelakamani kanugonnaru.
2008loe, gray journal off neurosciencelo modati rachayita kaagitaanni prachurinchindi, aame abhivruddhi chesina hetch. dii kosam oka navala transgenic mouse modalnu highlight chesindi. aame puurti-nidivi maanava utparivartana huntingtin janyuvunu vyaktam chese bacterial krutrima chromosomenu choppinchadam dwara elukalalo utparivartana huntingtin protein yokka vyakteekarananu saadhinchindi. batched elukalu pravartanaaparamgaa mariyu naralavyadhi saastraparamgaa hetch. dii. samalakshanaalanu pradarsinchaayi, mariyu idhi hetch. dii. vyadhikaaraka mariyu chikitsa saamarthyaanni adhyayanam cheyadaaniki vivo namoonaalo balamainadigaa maarindi.
vrutti.
2008loe, gray neuro generation und experimental therapeutics (cnet) kosam alabama birmingham vishwavidyaalayam centerlo neurology vibhaagamlo cheraaru. aame dickson scholar ayyindi mariyu 2010loe tenmark-track assistant professorga padoonnati pondadaaniki mundu rendu samvatsaraalu neurologylo bodhakudigaa unnaaru. gray center pharr glial biology inn medicine, evelin eff. thoo kooda anubandhamgaa undhi. mcnite brain institute, mariyu yuu. eah. bii. looni samagra neurosines center. aame parisoedhanaa paatralatho paatu, gray biomedical sciences (sibs) under graduate research prograamlo school off medicines sammarku saha-darsakatvam vahistundi mariyu aame huntington disease society off america yokka dharmakartala mandalilo undhi.
hetch. dii loe austrocytela paatranu anveshinchadampai drushti saarinchina prayogasaala yokka pradhana parisoedhakudu gray. hetch. dii. loe glial kanaala paatranu ardham chesukovadaniki aame thana parisoedhana drushtini glial biologyki maarchaalani nirnayinchukundi. hetch. dii. parisoedhana pradhanamgaa medium spiny neuranlapy drushti saarinchindi, ayinappatikee medadu kanaalalo ekkuva bhaagam glia mariyu avi medadulooni neurodegeneration mariyu vyaadhi prakriyalaku dohadapadevigaa ekkuvagaa gurtinchabaddaayi. gray thana post doctoral paniloo maargadarsakatvam vahinchina eluka namuunaanu utparivartana huntingtin protein yokka kana-rakam nirdishta vyakteekarananu saadhinchadaaniki upayoginchindi, vyaadhi vyaadhikaarakamlo yea kana rakam paatra poeshistumdoe vichhedanam cheyadaaniki mariyu neurodegeneration sambhavinche yantraamgaalanu marinta vichhedanam cheyadaaniki pratyaekamgaa straital medium spiny neuronlu mariyu cartical pyramid neuronlalo. hetch. dii lakshanaalanu meruguparachadaaniki gliotransmitterlanu savarinche saamarthyaanni kooda aame anveshistundi.
2021 eprillo, aame vamsapaaramparya vyaadhi foundation yokka shaastreeya borduku ennikayyaaru, idhi huntington vyaadhiki nivaarananu kanugonadam lakshyamgaa pettukundi.
parisoedhana.
2013loe, buudida rangu uab vadda thana prayogasaalanu praarambhinchina koddikaalaanike, elukalalo hechdi yokka batched namoonaalalo austrocytelu asaadhaaranamaina glutamate vidudalanu pradarsistaayani aame kanugondi. glutamate-madhyavartitva exytotoxicity neuronlanu gaayaparustundani telisinanduna, eee aavishkarana hetch. dii. vyaadhikaarakamlo austrocytelu sambhaavya paatra pooshistunnaayani suuchimchimdi. batched austrocytes loe asaadhaaranamaina glutamate vidudala yokka vidhaanaalanu anveshinchandi, buudida mariyu aame brundam mitochondrial enjaim pairuvet carboxylase sthaayilanu penchinatlu kanugonnaru, ayinappatikee kanamlo glutamatenu glutaminega marche enjaimlo etuvanti maarpulu laevu.
hetch. dii. lakshanaala vyakteekarana kosam austrocyteslo utparivartana huntingtin vyakteekarana avasaramaite buudida rangulo anveshistaaru. vaaru khagola kanaalalo utparivartana huntingtin yokka vyakteekarananu enchukoovadaaniki sharatulatho kuudina nock avutnu upayoginchaaru. austrocytelalo utparivartana huntingtin tolagimpu motaru kadalika mariyu manasika lakshanaalalo gananeeyamaina merugudalalaku daariteesindani vaaru kanugonnaru, idhi austrocytelu hetch. dii. loe vyaadhi pathologyki dohadam chestayani suuchistumdi.
budidarangu prayogasaala hetch. dii. vyaadhikaarakamlo khagola kanaalaku spashtamaina paatranu sthaapinchinanduna, vaaru hetch. dii. loe khagola kanaala paatraku antarleenamgaa unna sambhaavya yantraamgaalanu anveshinchaaru. vaaru modata gliotransmission pariseelinchaaru mariyu austrocytela nundi gliotransmitterla exocytosisnu nivaarinchadaaniki austrocytelaloni ucchu samudaayaanni nirodhinchaaru. khagola kanaalalo vala samudaayam nirodhinchabadinappudu konni panulalo pravartanaa paniteerulo mottam taggudalanu vaaru kanugonnaru, ayinappatikee rotoroid paniteeru 12 nelala vayassu merugupadi, oka praanta nirdishta vidhanam rogakaarakamlo nirdishta khagola kanaala janabha paatranu highlight cheyavachani suuchimchimdi.
empika chesina prachuranalu.
buudida, michel. (2019). huntington vyaadhiloo austrocytelu. 10.1007/978-981-13-9913-8 _ 14.