
skielman loop

skielman loops (skielman motiflu ledhaa paperclips anie kooda pilustaaru) saadhaaranamgaa proteins mariyu polypeptides yokka nirmaana lakshanaalu. pratidaaniloo aaru amaino aamlam avasheshaalu ("i" nundi "i" + 5 varaku label cheyabadina avasheshaalu) rendu nirdishta inter-mainchine hydrogen bandhaalu (diguva chitramlo, i) mariyu oka lakshana pradhana golusu diheadral konam conformation kaligi untaayi. avasheshaala "i" yokka saha samuuham avasheshaala "i" + 5 (eguva chitramlo rangu narinja) yokka nh kii hydrogen-bandham kaligi untundi, mariyu avasheshaala saha samuuham "i" + 1 anedi avasheshaala "i" + 4 (beata malupu, rangu oodaa) yokka nh kii hydrogen-bandham kaligi untundi. avasheshaalu "i" + 1 "," i "+ 2", mariyu "i" + 3 pratikuula φ (phi) konam viluvalanu kaligi untaayi mariyu avasheshaala "i" + 4 yokka phi viluva sanukoolamgaa untundi. skielman looplu moodu amaino aamlam avasheshaalu rl goodu (protein nirmaanaatmaka muulaamsam) nuu kaligi untaayi, dheenilo moodu pradhana golusu enhetch samuuhaalu (skielman loop avasheshaalu "ii" + 3 nundi "ii" + 5 varaku) carbonyl oxygenlaku hydrogen bandham kosam oka avatala bhaganni yerparustaayi. proteinlalo sumaru 2.5% amaino aamlalu skillman looplaku chendinavi. proteinlalo chinna muulaamsaalanu pariseelinchadaaniki rendu websitelu andubaatulo unnaayi, prerepita proteins ledhaa pdbemotif:.
ekkuva bhaagam skillman looplu (82 saatam) alfa-helix yokka sii-terminus vadda sambhavistaayi, antey avasheshaalu "i", "i" + 1 ", i" + 2 mariyu "i" + 3 helixlo bhaagam. naaluginta oka vanthu helix (28 saatam) loe sii-terminal skillman loop untundi.
appudappudu aaru avasheshaalaku badulugaa edu skellman looplu sambhavistaayi. veetilo, avasheshaala saha samuuham "i" anedi avasheshaala "i" + 6 yokka nh kii hydrogen-bandham, mariyu avasheshaala saha samuuham "i" + 1 anedi avasheshaala "i" + 5 yokka nh kii hydrogen-bandham. arudaina "edama chethi" aaru-avasheshaala skillman looplu sambhavistaayi; ivi oke hydrogen bandhaalanu kaligi untaayi, conny avasheshaalu "i" + 1 ", i" + 2, mariyu "i" + 3 saanukuula φ viluvalanu kaligi untaayi, ayithe avasheshaala "i" + 4 yokka φ viluva pratikuulamgaa untundi; goodu anedi rl, rakam kante lr yokka viluva.
saadhaarana rakam skielman loop yokka avasheshaalaku amaino assid propensitylu vivarinchabaddaayi. avasheshaalu "i" + 4 atyanta ekkuvagaa samrakshinchabadinavi; idhi saanukuula φ viluvalanu kaligi untundi; 70 saatam amaino aamlalu glycine mariyu edhee prolin kaadu.
pradhana golusu oxygenlaku kattubadi unna skielman loopla goollalo hydrogen bandham yokka pariseelana rendu pradhana rakaala erpaatlanu velladistundihi 1,3-sankareekrutam ledhaa kaadu. okadaanilo (diguva sankhya, ii) modati mariyu moodava goodu samuuhaalu oka oxygen anuvutho kalupabadataayi. marokadaanilo (diguva sankhya, iv) modati enhetch samuuham hydrogen, oka amaino aamlam yokka saha samuuhamtoe bandhinchabadindi, naalugu avasheshaalu kramamlo venukabadi untaayi, mariyu goodu enhetch samoohaalalo edhee vantena cheyabadavu. oohinchina daanikante skillman looplu takkuva sajaateeyamgaa unnatlu anipistundi.
asalu skielman pramaanaalu ippudu skielman looplugaa pariganinchabadani lakshanaalanu cherchadamlo phalitaanni istayi. modati peraalo kotta pramaanaala samiti ivvabadindi.