
robinson-gabriel samslaeshanha

robinson-gabriel samslaeshanha anedi oka sendriya praticharya, dheenilo 2-asilamino-keaton anuvula lopala pratispandistundi, taruvaata nirjaleekaranamtho oxazolnu istundi. 1909 mariyu 1910loe pratispandananu vivarinchina surr robbert robinson mariyu seagmund gabriel paeru meeda dheeniki paeru pettabadina praticharyanu utprerakam cheyadaaniki cyclodideriting agent avasaram.
2-asilamino-keaton prarambha padaarthaanni daakin-west praticharyanu upayoginchi samslaeshanha cheyavachu.
pratispandana yantraangam.
keato bhaagam (1) yokka protonation taruvaata cyclisation (2) mariyu nirjaleekarana (3), oxazole ring prarambha 2-asylamidocatone kante takkuva basic mariyu kabatti takshaname thatastheekarinchavachhu (4). labeling adhyayanalu amide oxygen atyanta levis basic anie nirdharinchaayi, anduvalla idhi oxazole loe cherchabadindi.
maarpulu.
iteevala, robinson-gabriel samslaeshanha yokka ghana-dasha version vivarinchabadindi. eee praticharyaku triphluoroacetic unhydride etherial draavanamloo cyclodideriting agentga upayoginchaali mariyu 2-asylamidocatone natrajani anuvu dwara benzedrylic-rakam linkertho anusandhaaninchaali.
oka saadhaarana oxazolone templetnu upayoginchi friedel-crafts/robinson-gabriel samslaeshanha dwara oka kunda vaividhyam-aadhaarita samslaeshanha abhivruddhi cheyabadindi. friedel-craft levis yasidga aluminium chloride mariyu robinson-gabriel cyclodideriting agentga trifluoromethanesalphonic assid kalayika kaavalasina utpattulanu utpatti cheyadaaniki nirnayinchabadindi.
robinson-gabriel cyclodidration yokka prasiddha podigimpunu wipf mariyu itarulu nivedinchaaru."takshaname labhinche amaino aamlam utpannaala nundi pratyaamnaaya oxazoles samshlaeshanhanu anumatinchadaaniki. dess-martin kaarakamtho β-keato amaidla side-chain aakseekarana dwara idhi saadhinchabadutundi, taruvaata triphenylphosphine, iodine mariyu trithylamine thoo intermediate β-keato amaidla cyclodidration dwara saadhinchabadutundi.
adanamgaa, yuji mariyu robinson-gabriel samslaeshanha nivedinchabadindi, idhi yuji kaarakaalato praarambhamai anuvu lopala oxazole core thoo mugustundi. oxazole yuji madhyantara nundi erpadutundi, idhi sulfuric aamlamtho robinson-gabriel cyclodidrationku anuvainadi.
cyclodideriting agentlu.
robinson-gabriel samshlaeshanhaloo aneka cyclodideriting agentlu upayogapadatayani kanugonabadindi. chaaritraatmakamgaa, nirjaleekarana agent anedi saandrata kaligina sulfuric aamlam. eee roeju varaku, eee praticharya phosphorus pentachloride, phosphorus pentoxide, phosphoryl chloride, theonyl chloride, phosphoric aamlam-acetic unhydride, polyphospheric aamlam mariyu nirjala hydrogen fluoridetho sahaa vividha itara agentlatho konasaagutundani choopabadindi.
applications.
aneka sahajamgaa verucheyabadina sammelanaalalo oxazoles saadhaarana uparitalaalugaa kanugonabaddayi, tadwara rasayana mariyu aushadha samaajamlo drushtini aakarshinchayi. diazonamide eah, diazonamide bii, bis-phosphine platinum (ii) complexelu, micalolide eah, (−)-muscoride eah vanti oxazolnu kaligi unna anuvulatho vyavaharinchae bahula adhyayanaalalo robinson-gabriel samslaeshanha upayoginchabadindi.
eric biran "mariyu itarulu."side-chain aakseekarana dwara dipeptides nundi ghana dasalo 1,3-oxazole-aadhaarita peptidela ghana-dasha samshlaeshanhanu abhivruddhi chesindi, taruvaata wipef mariyu miller yokka β-ketomides yokka cyclodidration paina vivarinchabadindi. 
lillie parisoedhanaa prayogasaalalu type 2 diabetispie prayojanakaramaina prabhavanni choope vivarinchina dual pparα/γ agonist yokka nirmaanaanni velladinchaayi. robinson-gabriel cyclodidration anedi agonist yokka rendu praticharya samshlaeshanhaloo rendava bhaagam. carbon-2thoo anusandhaaninchabadina modati pratyaamnaayaanni vaeru cheyadaaniki aspartic aamlam β esterlatho praarambhinchi, taruvaata rendava pratyaamnaayaanni pravesapettadaaniki daakin-west keto-amaidga marchadam, mariyu robinson-gabriel cyclodidrationtho 30 nimishala paatu 90 masim vadda dmflo phosphorus oxychloride ledhaa acetic unhydridelo utpreraka sulfuric aamlamtho mugustundi.