
enn. sii. 1

ectoderm-neural cartex protein 1 anedi maanavulalo "enk 1" janyuvu dwara encode cheyabadina protein.
function.
dna nashtam mariyu/ledhaa hyperproliferative signals wild type pii53 tumour suppressor protein (tipi53; mim 191170) nuu sakriyam chestaayi, idhi sell saikil arrest ledhaa apoptosisnu prerepistundi. p53nii nishkriyam chese utparivartanalu 50 saatam kanitulalo sambhavistaayi. polyac mariyu itarulu. (1997) p53 thoo sankraminchina colorectal cancer kana rekhalo cellular mrna sthaayilanu anchanaa vaeyadaaniki janyu vyakteekarana (sage) yokka krama vislaeshanhanu upayoginchaaru. gurtinchina 7,202 transcriptlalo, 14 matrame niyantrana kanaala kante p53-vyaktaparichae kanaalalo 10 retlu ekkuva sthaayilo vyakteekarinchabaddaayi. polyac mariyu itarulu. (1997) eee janyuvulanu 'p53-prerita janyuvulu' ledhaa pandulu anie pilicharu, veetilo chaalaa varaku redox-niyantrana proteinlanu encode chestayani anchanaa veyabadindi. reactive oxygen jaatulu (rose) apoptosis yokka saktivantamaina prerakaalu anie vaaru gurtinchaaru. pravaaha cytometric vislaeshanhaloo p53 vyakteekarana rose utpattini prerepistundani choopinchindi, idhi konni paristhitulalo apoptosis purogamistunnappudu perugutundi. ensi1 anie kooda piluvabade pig 10 janyuvu, actin-binding proteinnu encode chestundani rachayitalu paerkonnaaru.[omim dwara sarafara cheyabadindi]
paraspara charyalu.
enn. sii. 1 retinoblastoma proteintho sankarshana chendutundani choopabadindi.
jeevula namuunaa.
enn. sii. 1 function adhyayanamlo namuunaa jeevulu upayoginchabaddaayi. welcome trust sangar institutelo "enn. sii. 1tii. emm. 1eah (yucom) doubleu. tii. ess. ii" anae sharatulatho kuudina nakout mouse line roopondinchabadindi. tolagimpu yokka prabhavalanu nirnayinchadaaniki maga mariyu aada jantuvulu praamaanika samalakshana teraku gurayyayi. adanapu teralu pradarsinchabaddaayih-lothaina roganirodhaka drugvishayam 

