
p53 apoptosis yokka appregulated modulator

bii. sii. ell-2-binding component 3 (bbc3) anie kooda piluvabade apoptosis (puma) yokka pii53 appregulated modulator, idhi bii. sii. ell-2 protein kutumbaaniki chendina proo-apoptotic protein. maanavulalo, bii. sii. ell-2-binding bhaagam 3 protein "bii. bii. sii. 3" janyuvu dwara encode cheyabadutundi. pooma yokka vyakteekarana kaniti anichivese p53 dwara niyantrinchabadutundi. pooma vividha sankethaala dwara prerepinchabadina p53-aadhaarita mariyu-swatantra apoptosislo paalgontundi, mariyu transcription kaarakaala dwara niyantrinchabadutundi, anuvaadaanantara maarpula dwara kaadu. kriyaaseelakam chesina tarvaata, puma antiopoptotic bii. sii. ell-2 kutumba sabhyulatho sankarshana chendutundi, tadwara baaks mariyu/ledhaa baaknu vidipistundi, ivi appudu mitochondriaku apoptosisnu suuchimchagalavu. mitochondrial panicheyakapovadam taruvaata, cospace cascade sakriyam cheyabadutundi, idhi chivariki kanaala maranaaniki daariteestundi.
nirmaanam.
pooma protein anedi bii. sii. ell-2 kutumba proteinla yokka bii. hetch. 3-matrame upa samuuhamloo bhaagam. eee proteinla samuuham bii. hetch. 3 domainlo matrame krama saaruupyatanu panchukuntundi, idhi bii. sii. ell-2 mariyu bii. sii. ell-exl vanti bii. sii. ell-2-lanty proteinlatho paraspara charyalaku avasaram. nirmaanaatmaka vislaeshanha prakaram, pooma neerugaa antiapoptotic bii. sii. ell-2 kutumba proteinlatho bii. hetch. 3 domine dwara erpadina amphiphatic α-helical nirmaanam dwara bandhistundi. puma yokka mitochondrial sthaanikeekarana daani sii-terminal bhaagamlo hydrophobic domine dwara nirdesinchabadutundi. puma protein ksheenata 10va sthaanamlo samrakshinchabadina serin avasheshaala vadda phosphorylation dwara niyantrinchabadutundi.]
charya yokka yantraangam.
biochemical adhyayanalu puma bii. sii. ell-ex. ell, bii. sii. ell-2, emm. sii. ell-1, bii. sii. ell-doubleu, mariyu eah1 vanti antiapoptotic bii. sii. ell-2 kutumba sabhyulatho sankarshana chendutundani, propoptotic anuvulu, baaks mariyu baak latho vaati sankarshananu nirodhistundani choopinchaayi. veeti nirodham ettiveyabadinappudu, avi baaks yokka sthaanaantaragamanaaniki mariyu mitochondrial panicheyakapovadam yokka kriyaaseelataku daariteestaayi, phalitamgaa mitochondrial apoptogenic proteins cytochrome sii, smack mariyu apoptosis-inducing phyaaktar (aif) vidudala avtayi, idhi cospace kriyaaseelata mariyu kana maranaaniki daariteestundi.
bii. sii. ell-2 kutumba sabhyulatho bandhinchadaaniki puumaaku adhika anubandham unnanduna, maroka parikalpana emitante, pooma neerugaa baaks mariyu/ledhaa baaknu sakriyam chestundi mariyu baaks multimerisation dwara mitochondrial translocation prerepistundi mariyu daanitoe apoptosisnu prerepistundi. ayithe, apoptosisnu prerepinchadaaniki pooma baaks/buck thoo pratyaksha paraspara charyapai aadhaarapadadani vividha adhyayanalu choopinchaayi.
niyantrana.
prerana.
puma prerepita apoptosis loe ekkuva bhaagam kaniti nirodhaka protein p53 yokka kriyaaseelata dwara sambhavistundi. p53 glucose laemi vanti manugada sankethaala dwara sakriyam cheyabadutundi mariyu puma yokka vyakteekarana sthaayilanu penchutundi. puma sthaayilalo eee perugudala mitochondrial panicheyakapovadam dwara apoptosisnu prerepistundi. p53, mariyu daanitoe paatu pooma, vividha rakaala genotoxic agentla valla kalige DNA nashtam kaaranamgaa sakriyam cheyabadutundi. pii53 dependent apoptosisnu prerepinche itara agentlu neurotoxins, proteasome inhibitors, microtuble vishalu mariyu transcription inhibitors.
ancogenic stress groth phyaaktar mariyu/ledhaa cytokine upasamharana mariyu kines nirodham, err stress, marchabadina redox sthithi, ischemia, roganirodhaka modulation mariyu infection vanti itara uddeepanala dwara p53 kriyaaseelata nundi swatantramgaa puma apoptosis prerepinchabadavachhu.
ksheenata.
cytokine tgfbta, deth effector trial ledhaa anisomycin vanti rasayana aushadhaala vanti sankethaalaku pratispandanagaa, cospace-3 yokka kriyaaseelata dwara puma sthaayilu tagginchabadataayi mariyu serpace inhibitor enn-tossil-ell-phenylalanine chloromethyl keaton dwara nirodhinchabadina protease. puma protein proteazome aadhaarita paddhatiloo ksheenistundi mariyu daani ksheenata 10va sthaanamlo samrakshinchabadina serin avasheshaala vadda phosphorylation dwara niyantrinchabadutundi.
cancerlo paatra.
cancer kanaalalo puma paniteeru prabhaavitamavutundani ledhaa ledani aneka adhyayanalu choopinchaayi. adanamgaa, aneka maanava kanitulu p53 utparivartanalanu kaligi untaayi, ivi vikiranam ledhaa chemotherapy aushadhaala dwara prerepinchabadina DNA nashtam tarvaata kooda pooma preranaku daariteeyavu. itara cancerlu, ivi antiapoptotic bii. sii. ell-2 kutumba proteinla atigaa vyakteekarananu pradarsistaayi, pratighatana mariyu puma-prerita apoptosisnu atigaa prabhaavitam chestaayi. chaalaa cancer kanaalalo pooma paniteeru raajee padinappatikee, pooma yokka janyu nishkriyaatmakata cancerku pratyaksha lakshyamgaa unnatlu kanipinchadam ledhu. aneka cancerlu p53 janyu utparivartanaalanu pradarsistaayi, eee janyuvunu lakshyamgaa chesukune janyu chikitsalanu asadhyam chestaayi, ayithe puemanu lakshyamgaa chesukovadaniki mariyu cancer kanaalalo apoptosisnu prerepinchadaaniki chikitsapai drushti pettadam pratyaamnaaya maargam kaavacchu. kaniti anachivetalo pooma paatra pooshistundani janthu adhyayanalu choopinchaayi, ayithe pooma karyakalapalu lekapovadam valla matrame praanaantakaalu sahajamgaa erpadavu. puma prerita apoptosisnu nirodhinchadam anedi cancer chikitsala yokka dushprabhaavaalanu tagginchadaaniki oka aasaktikaramaina lakshyam kaavacchu, chemotherapy vantivi, ivi cancer kanaalanu vaegamgaa vibhajinchadamtho paatu aarogyakaramaina kanaalanu vaegamgaa vibhajinchadamlo apoptosisnu prerepistaayi.
puma p53 utparivartanalaku suuchikagaa kooda panichestundi. aneka cancerlu p53 janyuvulo utparivartanaalanu pradarsistaayi, conny eee utparivartananu vistrutamaina DNA sequencing dwara matrame gurtinchavacchu. p53 utparivartanalu unna kanaalu gananeeyamgaa takkuva sthaayi puemanu kaligi unnayani adhyayanalu choopinchaayi, idhi p53 utparivartanaala protein markerku manchi abhyardhigaa maarutundi, idhi p53 utparivartanalaku pareekshinchadaaniki saralamaina paddhatini andistundi.
cancer chikitsalu.
cancer rogulaku puemanu lakshyamgaa chesukune chikitsa agentlu udbhavistunnaayi. pooma inducerlu cancer ledhaa kaniti kanaalanu lakshyamgaa chesukuntaayi, ayithe keemo mariyu radiation therapy yokka avaanchaneeya dushprabhaavaalanu tagginchadamlo sahaayapadataaniki pooma inhibitarlanu saadhaarana, aarogyakaramaina kanaalanu lakshyamgaa chesukovacchu.
cancer chikitsalu.
chemotherapy ledhaa vikiranam lekunda ledhaa lekunda perigina pooma vyakteekarana cancer kanaalaku, mukhyamgaa oopiritittulu, thala mariyu meda, annavahika, melanoma, praanaantaka glioma, gastric grandhulu, rommu mariyu prostatelaku atyanta vishapuuritamainadani parisoedhanalu choopinchaayi. adanamgaa, p53 adenovirus kante puma adenovirus apoptosisnu ekkuvagaa prerepistundani adhyayanalu choopinchaayi. p53 kriyaaseelatanu nirodhinche mariyu parokshamgaa puma vyakteekarana sthaayilanu tagginche cancerlatho pooraadataaniki idhi prayojanakaramgaa untundi.
resveratrol, mokka nundi utpannamaina stillbenoid, prastutam cancer chikitsagaa parisoedhanaloo undhi. resveratrol antipoptotic bii. sii. ell-2 kutumba sabhyula vyakteekarananu nirodhinchadaaniki mariyu tagginchadaaniki panichestundi, adhe samayamlo pii53 vyakteekarananu kooda penchutundi. eee rendu vidhaanaala kalayika puma, noxa mariyu itara propoptotic proteinlanu sakriyam cheyadam dwara apoptosisku daariteestundi, phalitamgaa mitochondrial panicheyakapovacchu.
itara vidhanalu puma maadirigaane antiapoptotic bii. sii. ell-2 kutumba sabhyulanu nirodhinchadampai drushti pedataayi, cancer kaaryakalaapaalaku pratispandanagaa kanaalu apoptosis cheyinchukovadaaniki veelu kalpistaayi. eee inhibitorsto kuudina preclinical adhyayanalu, veetini bihech3 mimetics anie kooda pilustaaru, ivi aasaajanaka phalitaalanu icchaayi.
dushprabhava chikitsa.
aarogyakaramaina kanajaalamlo avaanchaneeya dushprabhaavaala dwara radiation therapy motaadu-parimitam cheyabadutundi. γ-vikiranam taruvaata hematopoietic mariyu pegu kanajaalamlo apoptosisnu prerepinchadamlo pooma churukuga unnatlu choopabadindi. pooma nirodham neerugaa aakasmika praanaantaka paristhitulaku kaaranam kaadu kabatti, aarogyakaramaina kanajaalamlo pooma paniteerunu nirodhinche chikitsa vidhanalu saampradaaya cancer chikitsala dushprabhaavaalanu tagginchavachhu ledhaa tolaginchavacchu.