
matiamide

matiamide anedi maroka hetch2 virodhi, burimamide nundi abhivruddhi cheyabadina histamine hetch2 grahaka virodhi. idhi vijayavantamaina anty-alsar drugg cemetidine (tagamet) abhivruddhilo oka madhyantara sammelanam.
burimamide nundi matiamide abhivruddhi.
saareeraka pihech vadda burimamide ekkuvagaa kriyaarahitamgaa undani kanugonna taruvaata, daani electron-daanam chese side chain undatam valla, burimamidenu sthireekarinchadaaniki eee krindi dasalu chepattabaddayi
eee maarpulu jeeva labhyata metiamidenu penchaayi, tadwara gastric aamlam yokka histamine-prerepita vidudalanu nirodhinchadamlo idhi burimamide kante padhi retlu ekkuva saktivantamainadi. 1973loe praarambhamaina clinical trials peptic alsarla vaidyam retunu penchadam dwara vranotpatti rogulaku rogalakshana upasamanaanni andinche matiamide saamarthyaanni pradarsinchaayi. ayithe, eee pareekshala samayamlo, matiamide motaadu teesukunna rogulalo aamodayogyam kaani sankhyalo agranulocytosis (tella rakta kanaala sankhya taggadam) abhivruddhi chendindi.
metiamidenu simetidinga marchadam.
agranulocytosisku theoria samuuham kaaranamani nirdhaarinchabadindi. anduvalla, theoria samuuhamloo theocarbonilnu bharti cheyaalani suuchimchaaru
nitro mariyu syano samuuhaalu porugu nitrogenla pica nuu theoria samuuham yokka adhe aamlataku tagginchadaaniki taginanta electronegativga untaayi, anduvalla saareeraka vaataavaranamloo aushadham yokka kaaryaacharananu kaapaadataayi.
samslaeshanha.
eethail 2-chloroacetoacete (1) nuu formide (2) yokka 2 molar samaanamaina vaatitho pratispandinchadam valla 4-carboethoxy-5-methylimidazole (3) labhistundi. birch taggimpu dwara drava ammonialo sodiyamtho carboxylic eestar (3) tagginchadam sambandhita alkahalnu istundi (4). systemine (mercaptoethylamine) thoo daani hydrochloridega daani praticharya, madhyantara 5kii daariteestundi. balamaina aamla maadhyamamlo, amine puurtigaa protonited avutundi; idhi theol pootii lekunda daani nucleophilicityni vyaktam cheyadaaniki anumatistundi mariyu aamlam kooda sthaanabhramsham vaipu alcoholic functionnu sakriyam chestundi. chivaraga, methyl isotheosynate amine ghaneebhavanam metiamidenu (6) istundi.

