
cinnorigin

cinnorigin anedi diphenylmethylperagina samuuhaaniki chendina antihistamine mariyu calcium chaanal blocker. chalana anaaroogyam ledhaa chemotherapy, vertigo ledhaa maniers vyaadhi vanti itara vanarula kaaranamgaa vikaram mariyu vaantulaku idhi suuchimchabadutumdi.
cinnorigin mottamodata 1955loe jansen pharmaceutica dwara aarr1575gaa samslaeshanha cheyabadindi. yajamanya rahita paeru natrajani anuvulalo okadaanipai cinnamile pratyaamnaayam nundi teesukobadindi, "antihistaminics/cerebral (ledhaa paridheeya) vasodilators" kosam saadhaarana mugimpu "-rijin" thoo kalipi. idhi united states ledhaa kenadaalo andubaatulo ledhu. british raayal neeveeloo samudrapu vyaadhiki ekkuvagaa upayoginche mandulalo idhi okatigaa kooda perkonabadindi.
vaidya upayogaalu.
cinnorigin pradhanamgaa chalana anaaroogyam, vertigo, maniers vyaadhi ledhaa cogans syndromtho sambandham unna vikaram mariyu vaantulaku chikitsa cheyadaaniki upayogistaaru.
nijaaniki, maniers vyaadhitho sambandham unna vertigo mariyu tinnitus yokka deerghakaalika chikitsalo prayojanakaramaina prabhavanni chuupina konni empika chesina aushadhaalalo idhi okati. ayithe, mandula valla magata sthaayilu peragadam valla, idhi saadhaaranamgaa pailatlu mariyu vimaana sibbandilo parimita upayogam kaligi untundi, vaaru nammadagina apramattamgaa undaali. oka clinical adhyayanamlo (n = 181), cinnerigin thoo chikitsa mitamaina vertigo anubhavanni 65.8% mariyu teevramaina vertigo 89.8% dwara tagginchindi. 
idhi kadalika gurinchi sankethaalanu pampe westibular juttu kanaala karyakalapalanu parimitam cheyadam dwara lopali chevi yokka westibular upakaranam mariyu hypothalamous yokka vaantula kendram madhya signal transmissionku antaraayam kaliginchadam dwara panichestundi. lopali chevi chalana grahakaalu mariyu drushya indriyaala madhya signal prosessing asamaanata raddu cheyabadutundi, tadwara vyakti kadulutunnada ledhaa nilabadi unnada anae medadulooni gandaragolam taggutundi. chalana anaarogyamlo vaantulu anedi vyakti kadalakunda undataaniki medadu yokka saareeraka parihara yantraangam kaavacchu, tadwara idhi signal avagahanaku anugunamgaa untundi, conny eee vyaadhiki nijamaina parinaamaatmaka kaaranam prastutam teliyadu.
santulanam samasyalu mariyu vertigo kosam suuchimchinappudu, prati motaadu mottaanni batti cinnerigin saadhaaranamgaa rojuku rendu ledhaa moodu saarlu teesukobadutundi mariyu chalana anaaroogyaaniki chikitsa cheyadaaniki upayoginchinappudu, maatra prayaanaaniki kaneesam rendu gantala mundu mariyu prayaana samayamlo prati naalugu gantalaku okasari teesukobadutundi. ayithe, samudrapu vyaadhi chikitsa kosam cinnorigin yokka prabhavalanu transdermal skopolamaintho polchina iteevali 2012 adhyayanam, scopolamine gananeeyamgaa marinta prabhaavavantamgaa mariyu cinnorigin kante takkuva pratikuula dushprabhaavaalanu kaligi unnatlu nivedinchabadindi. idhi naavikaadala sibbandi mariyu itara samudra prayaanikulaloo chalana anaaroogyam chikitsaku transdermal scopolamine merugaina empika anae nirdhaaranaku daariteesindi.
anty-vertigo chikitsaku minchi, cinnorigin nuu nootropic aushadhamgaa kooda chudavachu, endukante daani vasoreloxating saamardhyalu (calcium chaanal digbandham kaaranamgaa), ivi ekkuvagaa medadulo jarugutaayi mariyu idhi chikkaina upasamanakaarigaa kooda upayoginchabadutundi. cinnerigin erra rakta kanaalaloki calcium pravahanni nirodhistundi, idhi kana goda yokka sthithisthaapakathanu penchutundi, tadwara vaati vasyatanu penchutundi mariyu raktaanni takkuva jigataga chestundi. debbatinna kanajaalaaniki oxygennu teesukuraavadaaniki irukaina naalaala dwara raktam marinta samarthavantamgaa mariyu samarthavantamgaa prayaaninchadaaniki idhi anumatistundi. idhi itara nootropiklatho kooda samarthavantamgaa militam cheyabadutundi, pradhanamgaa pyrasetum; atuvanti kalayikalo prati aushadham medadu oxygen sarafaraanu penchadamlo marokadaanni saktivantam chestundi. cinnorigin mariyu flunarigin (taatkaalika global cerebral ischemia chikitsaku 2.5-15 retlu balamgaa unde cinnorigin yokka utpannam) yokka prabhavanni polchina oka janthu adhyayanam, cinnorigin ischemia yokka kriyaatmaka asaadhaaranatalanu meruguparachadaaniki sahaayapadindani kanugonabadindi, conny neuronlaku nashtam kaliginchadamlo sahayapadaledu. marovaipu, flunarigin marinta neuronal rakshananu andinchindi, conny tadupari pravartanaa maarpulaku chikitsa cheyadamlo takkuva prabhaavavantamgaa undhi.
adanamgaa, kendra naadii vyavasthalo praanavaayuvu vishapuuritam ayye pramaadam lekunda scooba diverlalo cinnorigin nuu upayoginchavacchu, idhi muurchalaku daariteestundi mariyu closed-circuit praanavaayuvu divinglo adhika pramaadam kaligi untundi. adhika oxygen peedanaanni upayoginche mariyu edainaa cinnerigin-prerita cns oxygen vishapuurita pramaadamtoe kooda prabhaavitamayye hypobaric ottidi taggimpu chikitsa cheyinchukovalsina diverlaku kooda idhi vartistundi. ayithe, cinnorigin vishapuurita pramaadaanni penchadu, vaastavaaniki, kendra naadii vyavasthalo oo2 vishapuuritatanu alasyam cheyadamlo cinnorigin prayojanakaramgaa undavacchani aadharalu suuchistunnaayi.
kramam tappakunda teesukunnappudu cinnorigin nuu samarthavanthamaina astama nirodhaka aushadhamgaa upayoginchavacchani kooda aadharalu unnaayi.
idiopathic articareal vasculitisku cinnerigin kooda viluvaina rendava-varusa chikitsagaa kanugonabadindi.
dushprabhaavaalu.
cinnerigin teesukunnappudu dushprabhaavaalu telikapati nundi chaalaa teevramaina varaku untaayi. magata, chemata pattadam, noru podigaa undatam, talanoppi, charma samasyalu, alasata, jeernasayaantara chikaku, adhika sunnitatva praticharyalu, alaage kadalika samasyalu/kandaraala drudhatvam mariyu prakampanalu vanti dushprabhaavaalu sambhavinchavachhu. cinnerigin magata mariyu aspashtamaina drushtini kaligistundi kabatti, viniyogadaarulu driving, operating mationary ledhaa vaaru puurtigaa apramattamgaa lekunte ledhaa baga chudalekapothe pramaadakaramaina itara panulanu chese mundu vaari praticharyalu saadhaaranamainavani nirdhaarinchukovadam chaalaa mukhyam.
dii2 graahakaala patla daani anubandham kaaranamgaa cinnorigin teevramaina mariyu deerghakaalika parkinsonism kaligistundi, idhi neurohealthnu meruguparachadamlo daani vaastava upayogaanni balamgaa suuchistumdi. stritumlo dii2 dopamine graahakaala yokka cinnerigin yokka vyatiraeka prabhavalu niraasa, prakampanalu, kandaraala drudhatvam, tardive diaskinitia mariyu akatisia lakshanaalaku daariteestaayi, ivi aushadha-prerita parkinsons vyadhiga vargeekarinchabaddaayi mariyu parkinsonsku rendava pradhana kaaranam. aushadha-prerita parkinsons abhivruddhiki dohadapadatamlo churukaina paatra poeshinchae cinnerigin, sii-2 yokka gvakriyalo idhi okati anie aadharalu suuchistunnaayi. 100 kotta parkinsons kesulalo 17 kesulu cinnorigin ledhaa flunarigin paripaalanato mudipadi unnayani, idhi cinnorigin mariyu aushadha-prerita parkinsonsnu teevramaina samasyaga maarustundani kooda gamaninchaali. mukhyamgaa vruddha rogulu, mukhyamgaa mahilalu mariyu ekkuva kaalam nundi eee aushadhaanni teesukuntunna rogulu mukhyamgaa pramaadam unna vyaktulu. parkinsons yokka kutumba charitra ledhaa vyaadhiki janyu siddhata unna rogulu cinnerigin chikitsa phalitamgaa eee vyaadhi yokka aushadha prerita roopaanni abhivruddhi chese avakaasam undani soochinche aadharalu kooda unnaayi.
vyatiraeka dii2 graahakaalato paatu, cinnerigin thoo chikitsa kooda taggina presinaptic dopamine mariyu serotonin kuu daariteestundani, alaage dopamine yokka vesicular ravaanaalo maarpulaku daariteestundani choopabadindi. terland mariyu itarulu. cinnerigin thoo deerghakaalika chikitsa anedi aushadha saandratalanu taginantagaa penchutundani, avi dopamine nuu vesicals loki packaging cheyadaaniki avasaramaina protan electrochemical gradientku antaraayam kaligistaayani choopinchaayi. cinnorigin, pca = 7.4, protonophorga panichestundi, idhi dopamine vesicals loki ravana cheyadaaniki mariyu nilva cheyadaaniki keelakamaina electrochemical gradient yokka mgatp-aadhaarita utpattini nirodhistundi, tadwara besal ganglia neuronlalo dopamine sthaayilanu taggistundi mariyu parkinsons lakshanaalaku daariteestundi.
adanamgaa, pediatric mariyu vayojana cinnorigin adhika motaadu yokka aneka kesulu nivedinchabaddaayi, veetilo somnolens, coma, vaantulu, hypotonia, muurcha mariyu muurcha vanti lakshanaala shreni unnaayi. abhignaa samasyalu cinnorigin yokka antihistaminic prabhaavaala valla sambhavinchavachhu, ayithe motaru prabhavalu antidopaminergic lakshanaala yokka utpatti. adhika motaadu vishayamlo, sambhaavya naraala samasyala kosam rogini aasupatriki teesukuvacchi, gamaninchaali.
pharmacokinetics.
cinnorigin saadhaaranamgaa noti dwara, maatra roopamlo teesukobadutundi, mandulu teesukoovadaaniki kaaranaanni batti frequency mariyu motaadu parimaanam maarutuu untundi. 
okasari teesukunna tarvaata, padaartham chaalaa vaegamgaa grahinchabadutundi mariyu paripalana tarvaata 1 nundi 3 gantallo garishta plasma saandrataku cherukuntundi. pareekshinchina praantamloo (saadhaaranamgaa rakta plasma) aushadham yokka garishta sthaayi ayina CMX, 275 +/- 36 ng/ml gaa kolustaaru, ikkada Tmax, raktamlo garishta mottamlo aushadham unna samayam, 3 +/- 0.5 gantalu. jeeva labhyatanu anchanaa vaeyadaaniki upayoginchagala auc φ, (vakrarekha krinda unna praantam anantam varaku vistarinchabadindi), 4437 +/- 948 (ng.hetch/ml). sagam-jeevita tolagimpu vayassu batti 3.4-60 gantala nundi maarutuu untundi. ayithe, 75 mii. graa. cinnorigin icchina yuva swachchanda sevakulaku sagatu ardha-jeevita tolagimpu 23.6 +/- 3.2 gantalu anie kanugonabadindi.
aarogyakaramaina swachchanda sevakulaku rojuku rendusaarlu pannendu rojula paatu 75 mii. graa. cinnerigin motaadulanu icchina oka adhyayanam, cinnerigin sareeramlo sthiramaina-sthithi perukupoye karakam 2.79 +/- 0.23 thoo perigindani gamaninchindi. ayithe, eee samayaniki (t = 12 rojulu) aakt anedi auc φ nundi gananeeyamgaa bhinnamgaa ledhu, idhi oke motaadu paripalana nundi anchanaa veyabadindi. takkuva jala draavaneeyatatoo chaalaa balaheenamaina praathamika mariyu lipophilic sammelanamgaa, cinnorigin saadhaarana vyaapti dwara rakta medadu addankini daatagaladu. eee lakshanam kaaranamgaa idhi medadulooni mastishka rakta pravaahampai daani prabhavalanu chuupagaladu.
noti dwara ivvabade cinnorigin yokka jeeva labhyata saadhaaranamgaa takkuvagaa untundi mariyu adhika ksheenata kaaranamgaa maarutuu untundi. ayithe, lipid emulsionlo sirala dwara icchinappudu, merugaina pharmacokinetics mariyu kanajaala pampinhee saadhinchinatlu kanugonabadindi. lipid emulsion administration draavanam roopam kante adhika aak mariyu takkuva clearance kaligi undhi, antey cinnorigin yokka jeeva labhyata perigindi, idhi merugaina chikitsa prabhaavaaniki veelu kalpistundi. sirala dwara ivvabade cinnerigin yokka plasma pharmacokinetics moodu-compartment namuunaanu anusaristundi, modata vegavantamaina pampinhee dasha, taruvaata nemmadigaa pampinhee dasha, mariyu chaalaa nemmadigaa tholagimputho mugustundi. lipid emulsion administration kosam verses (sthiramaina sthithi spashtamaina pampinhee parimaanam) draavanamloo icchina cinnerigin (14.018 +/- 5.598 l/kilolu) kante 2 retlu takkuvagaa (6.871 +/- 1.432 l/kilolu) undhi mariyu lipid emulsion sthithilo oopiritittulu mariyu medaduloki gananeeyamgaa takkuva cinnerigin teesukobadindani kanugonabadindi. idhi mukhyamainadi endukante idhi kendra naadii vyavasthalo vishapuurita dushprabhaavaala sambhaavyatanu taggistundi.
pharmacodynamics.
cinnorigin tii-rakam voltage-operated calcium ayan chaanella yokka empika chesina virodhigaa vargeekarinchabadindi, endukante daani binding chaanellanu addukuntundi mariyu vaatini jadamgaa unchutundi. idhi 22nm yokka kii (nirodhaka sthiraamkam) viluvanu kaligi untundi. idhi antihistaminic, antiserotonergic mariyu antidopaminergic prabhavalanu kaligi untundi, ivi hetch1 histamine grahakaalu mariyu dopaminergic (dii2) graahakaalaku bandhistaayi. mruduvaina kandaraala sankocham nirodham kosam cinnerigin yokka aisi 50 (sagam-garishta nirodhaka ekagrata) 60 mimi mariyu eee aushadham moosivesina aakrutiki viruddhamgaa, bahirangamgaa unnappudu daani lakshya calcium chaanellaku praadhaanyatatoo bandhistundani choopabadindi. vikaram mariyu chalana anaaroogyam chikitsalo, lopali chevilooni type II westibular hair selslo voltage gated chaanellalo calcium pravahalanu nirodhinchadam dwara cinnerigin daani prabhavalanu chooputundani gatamlo oohinchabadindi. edemaina, aushadhashaastraparamgaa sambandhita sthaayilalo (0.3μm-0.5μm), cinnorigin calcium chaanellanu nirodhinchadam dwara westibular vertigonu tagginchadam ledani, juttu kanaalapai hydrostatic ottidi dwara sakriyam cheyabadina potassium (k +) pravahalanu nirodhinchadam dwara anae aalochanaku iteevali aadharalu maddatu istayi. cinnerigin westibular hair selslo calcium pravahalanu kooda raddu chestundanedi nijam; idhi aushadham yokka adhika saandratala vadda (3 micromy) matrame sambhavistundi. eee pravahalanu nirodhinchadam anedi westibular hair sels yokka adhika-reactivityni tagginchadam dwara vertigo mariyu chalana-prerita vikaram tagginchadaaniki panichestundi, ivi medaduku samatulyata mariyu kadalika gurinchi samacharanni pamputaayi.
tolagimpu.
icchina taruvaata, cinnorigin sareeramlo puurtigaa jeevakriya cheyabadutundi mariyu moothramlo moodinta oka vanthu mariyu ghana vyardhaalalo moodinta rendu vantula gvakriyalu tolaginchabadataayi.