apprecitabine

apprecitabine (inn, sanketanamam sanketanamam mariyu sp sp, konnisaarlu etisi anie sankshipteekarinchabadindi) anedi hechaiviki vyatiraekamgaa prayogaatmaka nucleoside riverse transcriptase inhibitor (nrti). idhi nirmanatmakamga lamivudin mariyu emtricitabinelaku sambandhinchinadi, mariyu eee vidhamgaa, cytidine yokka analog.
charitra.
dheenini modata biochem forma abhivruddhi chesindi (ikkada dheenini bii. sii. hetch. 10618 anie pilicheevaaru). biochem formanu shair pharmaceuticals (ikkada aprecitabine spd754 anie pilicheevaaru) kuu vikrayinchaaru. shair aaa aushadhaanni abhivruddhi chese hakkulanu australian pharmaceutical company ayina avexa pharmaceuticalsku vikrayinchindi. apprecitabine daani moodava dasha clinical trialnu moosivesindi mariyu united states phud und drugg administration dwara faast track hodaanu manjuru chesindi.
mae mae apprecitabinepy panini nilipiveyaalane thana nirnayaanni avexa prakatinchindi, idhi $100 millionlaku ($90 millionlu) paiga kharchu chesindi mariyu saadhaaranamgaa yuu kosam avasaramaina roogi adhyayanala yokka moodu dasalalo chivari dasalo undhi.ess. niyantrana aamodam. prapancha licensing kosam vaanijya bhaagaswaamulanu kanugonalekapovadam, us marketlo aushadham yokka chattaparamaina rakshanala gurinchi aandolanalu mariyu itara retroviral mandulu keelaka suuchikalanu musugu chesina rogulalo aushadham yokka prabhavanni nirdhaarinchadamlo ibbandi vantivi moosivetaku karanaluga unnaayi.
marchi marchi australia stock ekschenjeeki company prakatinchina prakaram, 2 vaaraala paatu motaadu teesukunna sumaru 300 mandhi rogulatho sahaa kotta, chinna, single faze III trial design aamodam pondadaaniki mundu avasaramani fda angeekarinchindi. marchi marchi ematho idhe vidhamaina oppandam prakatinchabadindi.
2011 navambarulo company apprecitabine paie thana petentlanu vistarinchadaaniki prayatninchindi mariyu european regulatorlatho vegavantamaina aamodam kosam charchallo undhi. lamivudin anae maroe nrtitho poliste, rendu itara vikrayinchina aushadhaalato paatu ekakaalamlo aushadhaanni andinchadam dwara clinical trials oohinchina daanikante merugaina phalitaalanu chuupaayani kooda company suuchimchimdi.
suuchimchimdi avexa yokka taja naveekarana eee aushadham inca iib trialslo undani mariyu inca moodava dasha praarambhinchaledani nivedinchindi.
motaadu.
monotherapyga, rojuku 1200 mii. graa. apprecitabine oka chinna, 10 rojula yaadruchchika niyantrita trial loe viral lodnu 1.65 laaglu (45 retlu) varaku tagginchindi. taruvaata adhyayanaalalo rojuku rendusaarlu 800 mg motaadu upayoginchabadutondi.
pratikuula prabhavalu.
apprecitabine baga thattukogaladani telustondi. daani vaadakamtho mudipadi unna atyanta saadhaarana dushprabhaavaalu talanoppi (apprecitabine teesukunna paalgonevaariki mariyu placebo icchina vaariki madhya gananeeyamaina vyatyaasam laenappatikee), nasika raddi mariyu kandaraala noppi. aaru nelala vichaaranalo, saadhaarana pratikuula prabhavalu vikaram, atisaaram, triglyzarides yokka perigina rakta sthaayilu mariyu eguva swaasakosha sankramana-lamivudin maadirigaane; apprecitabine asaadhaarana lipace sthaayilu, emuka majja anachiveta ledhaa kaaleyam mariyu moothrapindaala vishapuuritatvamtoe sambandham kaligi ledhu. yea adhyayanamlo kooda yea rogulu dushprabhaavaala kaaranamgaa apprecitabine teesukovadam maaneyaalsina avasaram raaledu.
aushadha nirodhakata.
"inn vitro", apprecitabine nrt-(lamivudin mariyu gdovudin)-nirodhaka virus jaatulaku vyatiraekamgaa prabhaavavantamgaa untundi, veetilo veetilo mariyu bahula thymidine analog utparivartanaalu (toms) unnaayi.
prarambha adhyayanaalalo, aushadha nirodhakataku kaaranamayye utparivartanalu aevee gamaninchabadaledu. kotta trials prakaram apprecitabine k65r utparivartanaalanu prerepinchagaladani, phalitamgaa didanosine mariyu tenofovirku vyatiraekamgaa nirodhakata erpadutundani choopinchindi.
clinical adhyayanaalalo, apprecitabine viral lodlanu tagginchadamlo baga panichestundi, ayithe spashtamgaa takkuva empika ottidini utpatti chestundi, phalitamgaa m184v ledhaa k65r ledhaa toms (m41l, m184v, mariyu t215y) thoo sahaa mundugaa unna saadhaarana utparivartanaalato chikitsalo anubhavam unna rogulalo tadupari utparivartanalu laevu.

