
pensyllamine

pensyllamine, itarulatoe paatu cupremin brand paerutoe vikrayinchabadutundi, idhi pradhanamgaa willson vyaadhi chikitsa kosam upayoginche aushadham. moothramlo systeine sthaayilu, rheumatoid arthuritis mariyu vividha heavy metal vishalu unna moothrapindaallo raallu unnavaariki kooda dheenini upayogistaaru. idhi noti dwara teesukobadutundi.
pensyllamine 1970loe united stateslo vaidya upayogam kosam aamodinchabadindi. idhi prapancha aarogya samstha yokka avasaramaina aushadhaala jaabitaalo undhi.
vaidya upayogaalu.
idhi chelating agentga upayoginchabadutundih
systenurialo, adhika moothra systeine sthaayilu systeine raallu erpadataaniki daariteese vamsapaaramparya rugmata, pensyllamine systeintho bandhinchi systeine kante ekkuva karige mishrama disulfidenu istundi.
scleroderma chikitsaku pensillamine upayoginchaaru.
saampradaaya chikitsa yokka taginanta vichaaranaku spandinchadamlo viphalamaina rogulalo teevramaina kriyaaseela rheumatoid artharaitisku chikitsa cheyadaaniki pensyllamine nuu vyaadhi-savarinche anty rheumatic aushadhamgaa (dmrd) upayoginchavacchu, ayithe tnf inhibitors mariyu tosilizumab mariyu tofacitinib vanti itara agentla labhyata kaaranamgaa eee roeju idhi chaalaa arudugaa upayoginchabadutundi. tii-lymphocytela sankhyanu tagginchadam, macrophage paniteerunu nirodhinchadam, ill-1nii tagginchadam, rheumatoid karakanni tagginchadam mariyu collagen cross-linking nundi nirodhinchadam dwara pensyllamine panichestundi.
pratikuula prabhavalu.
saadhaarana dushprabhavalalo daddurlu, aakali lekapovadam, vikaram, virechanaalu mariyu takkuva rakta tella rakta kanaala sthaayilu unnaayi. itara teevramaina dushprabhavalalo kaaleya samasyalu, oliterative branchiolitis mariyu mayasthenia gravis unnaayi. lupus erythematosus unnavaarilo idhi sifaarsu cheyabadadu. garbhadhaarana samayamlo upayoginchadam valla sisuvuku haani jaragavacchu. pensyllamine bhaarii lohalanu bandhinchadam dwara panichestundi; phalitamgaa pensyllamine-loha samudaayaalu moothramlo sareeram nundi tolaginchabadataayi.
emuka majja anachiveta, diasgetia, anorexia, vaantulu mariyu virechanaalu atyanta saadhaarana dushprabhaavaalu, ivi pensyllamine thoo chikitsa pondina rogulalo ~20-30% loe sambhavistaayi.
itara sambhaavya pratikuula prabhavalu
rasayana shaastram.
pensyllamine anedi oka trividha sendriya sammelanam, indulo theol, amine mariyu carboxylic aamlam untaayi. idhi amaino aamlam nirmaanaparamgaa systeine maadirigaane untundi, conny theolku geminal dimethyl pratyaamnaayaalu α thoo untundi. chaalaa amaino aamlaala maadirigaane, idhi saareeraka ph vadda zvitarionic roopamlo unde ranguleni ghanapadaartham. 
pensyllamine anedi oka stereogenic center kaligina kairal aushadham mariyu idhi oka jatha ananciomersga untundi. pensyllamine ananciomers nirmaanam kosam chitraanni chudandi. (luu)-ananciomer, eutomer, anty arthoritic ayithe distomer (aarr)-pensyllamine chaalaa vishapuuritam. daani rendu ananciomerlalo,-pensyllamine ("r" sampoorna aakruteekarananu kaligi untundi) vishapuuritam endukante idhi pyridoxin (vitamin b6 anie kooda pilustaaru) charyanu nirodhistundi. anantiomer anedi pencillin yokka metabolite, conny antibiatic lakshanaalu laevu. vividha rakaala pensyllamine-raagi sanklishta nirmaanaalu telisinavi.
charitra.
zaan walshey 1956loe willson vyaadhiloo pensyllamine vadakanni modatisaarigaa vivarinchaadu. pencillin teesukunna rogula (thanatho sahaa) moothramlo eee sammelanaanni kanugonnadu, mariyu idhi chelation dwara moothramlo raagi visarjanan penchutundani prayogaatmakamgaa dhruvikarinchaadu. willson vyaadhi pradhanamgaa raagi homeostasis samasya kaadani, amaino assid jeevakriya samasya anie, dimercaprolnu cheletargaa upayoginchaalani vaaru bhaavinchinanduna, aaa kaalamlooni aneka mandhi prapancha nipunulanu (denny braun und cummings) daani samarthatha gurinchi oppinchadamlo aayanaku prarambha ibbandi eduraindi. taruvaata adhyayanalu raagi-kendrikruta siddhaantam mariyu-pensyllamine yokka samarthatha rendintinee dhruvikarinchayi. willson yokka triathylene tetramine mariyu tetratheomolibdate vanti itara cheletarlaku kooda walshey maargadarsakatvam vahinchaaru.
robbert robinson paryaveekshanhaloo zaan cornforth pensillamine modata samslaeshanha chesaaru.
1964loe modati vijayavantamaina kesu nundi rheumatoid artharaitislo pensyllamine upayoginchabadindi.
kharchu.
united stateslo, valient 2016loe aushadhaala dharanu sumaru $500 nundi $24,000 kuu penchaaru.

