
gwa aperon

inosine monophosphate (imp ledhaa innocinate) nundi purin nucleotide ayina gwanosin mono fasfate (zii. emm. pii) samshlaeshanhanu niyantrinchadaaniki gwa operon baadhyata vahistundi. idhi promoter mariyu operator praantam kakunda rendu nirmaanaatmaka janyuvulanu kaligi untundi (imp dehydrogenase kosam encodes ledhaa mariyu gwa (gmp synthetase kosam encodes).
purin biosynthesis.
purin biosynthesis yokka modati kattubadi dasha 5-phosphoribosyl 1 pyrophosphate nundi praarambhamavutundi. idhi maargamlo oka mukhyamaina saakha binduvu ayina impnu roopondinchadaaniki praticharyala shreniki lonavutundi. aaa maargam taruvaata saakhalu adenylosinate yerparustaayi, aapai oka saakhalo adenylate (ampere) mariyu maroka saakhalo janthylate (exmp) mariyu taruvaata gwanilate (gmp) nuu yerparustaayi. imp dehydrogenase impnu exmpga marchadanni utprerakam chestundi mariyu gmp synthetase exmpni gmpga marchadanni utprerakam chestundi.
niyantrana.
kanam yokka jeevakriya sthithilo maarpulaku operon pratispandinchaali. idhi vruddhi raetu aadhaarita niyantrana, kathinamaina niyantrana (kanam edurkone vividha ottilla samayamlo niyantrana) mariyu itara rakaala niyantranalaku lobadi untundi. anduvalla bahya madhyamam nundi gwanine pondagaligite adhi jeevasamshleshananu aaputundi, nucleotidelu avasaramaite daani vyakteekarananu penchutundi (udaaharanaku dna replication samayamlo) mariyu amp mariyu pyrimidine nucleotidelaku sambandhinchi gmp utpattini samatulyam chestundi.
paina perkonna branch point, ampere mariyu zii. emm. pii. la samatulya utpattini kaligi undataaniki kathinamaina node nuu gattiga niyantristundi. gwa operaannu zii. emm. pii. anachivestundi mariyu ampere dwara prerepinchabadutundi. adevidhamgaa ampere samshlaeshanhanu ampere dwara anachiveyabadutundi, ayithe idhi zii. emm. pii dwara sakriyam cheyabadutundi. eee dwandwa niyantrana ampere mariyu zii. emm. pii madhya fluxes samatulyata undela chestundi mariyu fluxes vibhajana kalavaralu edurainappudu kooda saapekshamgaa sthiramgaa untundi. eee niyantrananu saadhinche konni vidhanalu krinda charchinchabaddaayi.
gwa operon yokka niyantrana yokka konni vidhanalu.
dna replicationku gwanine nucleotidela sarafara avasaram kabatti, dna replication mationary mariyu gwa operon madhya kontha samanvayam undaali. idhi jarige oka paddhati DNAa protein. DNAa anedi oka protein, idhi replication yokka muulaanni gurtistundi, oka ritch DNA praantam yokka sthaanika viramanni prothsahistundi mariyu chivaraku helicase DNAB nii daani pravesha pradaesaaniki maarganirdesam chestundi. dna anedi taginanta gaadatalo unte dna pratiruupanaku kaaranamayye pratiruupana prarambha karakam.
replication jariginappudu, replication yokka muulam DNAa proteinla kosam "sink" nuu srushtistundi. kabatti dna dwara pratikuulamgaa modulate cheyabadina janyuvulu, gwa operon maadirigaa derepress cheyabadataayi. rendu sambhaavya dna binding saitlu, okati gwa promoterpy mariyu marokati 200 bipi diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva diguva modati mariyu taruvaati sannivesaalu rendoo oka paatra poeshistaayani bhaavistaaru, taruvaati bhaagam keelakamainadi mariyu eee shrenula vadda DNA binding janyuvu yokka transcription pratikuulamgaa prabhaavitam chestundi.
vruddhi raetlu takkuvagaa unna madhyamalalo perugutunnappudu, shibiram niyantrana lakshanaalanu kaligi unna sanklishtatanu yerparustunna shibira grahaka proteintho bandhistundi. eee samudaayam gwab transcription prarambha sait yokka 100 bipi eguva praanthamtho bandhistundi, idhi taruvaata gwa aaperannu anachivestundi. eee sanklishtata sumaru 100 bitt/seey dhooram nundi rna paalimaresto elaa sankarshana chendutundane daanipai charchaneeyaamsam. oka drukpatham teliyani niyantrana karakam yokka prameyaanni suuchistumdi. edemaina, sanklishtamaina vruddhi raetu aadhaarita niyantrananu aperon yokka promoter praantaaniki andistundi.
pure janyuvula dwara encode cheyabadina repressor pure purin biosynthesislo palgone enjaimla samshlaeshanhanu niyantristundi. gwa promoterlo oka putative 16 bipi purr operator kanugonabadindi. purr repressor itara koo-repressorlatho panichestundi, udaaharanaku gwanine, idhi "ii" loe koo-repressor. kolai ".
transcript yokka modati 37 nucleotidelanu kaluputuu sthiramaina stem-loop secondary structurenu roopondinche saamarthyam gwa marnah leaderku undhi. ribosome binding sait stem looplo vaeru cheyabadinanduna, eee nirmaanam anuvaada niyantranalo paalgonavacchu.
gwa promoter xsea pramotartho kalisi untundi (asamatulya marammattu enjaim exonucles viinii encoding chestundi). prothsaahakulu atuvanti daggari antaraanni niyantrinche praamukhyatanu kaligi undavacchu mariyu rna polymerase anuvulu ekakaalamlo bandhinchadaaniki prayatnistunnanduna steric addanki daariteestundi. oka promoternu nishkriyam cheyadam sahajamgaane maroka promoter yokka ekkuva vyakteekaranaku daariteestundi. itara vidhanalalo phis (inversion stimulation kosam karakam) unnaayi, idhi rna polymerase bindingnu stericalga addukuntundi. conny phis paatra inca sarigga parisodhinchabadaledu.
eucariotslo homolaglu.
jeevakriya maargam jaatula antataa samrakshinchabadinanduna, janyuvulu kooda okela untaayi. sacaromysis serevisia" loe niyantranapai vistrutamaina adhyayanalu jarigaayi. eest looni janyuvulu mariyu guwa1 yokka imd kutumbam guwab mariyu guwa laku anugunamgaa untundi. ikkada mottam operon sunnitamgaa unde prokariyotlalo maadirigaa kakunda, kevalam imd janyuvulu matrame gwanine sunnitamainavi mariyu gwawa1 kaadu. imp dehydrogenase nirodhakam ayina mycophenolic aamlam, imd 2 janyuvu yokka prerakamu (anduvalla imd 2 bahusha antargata aushadha karyakalapalanu kaligi untundi. eucariotic niyantrana chaalaa bhinnamgaa unde maroka amsam emitante, eukariotlu ampere mariyu zii. emm. pii. kii daariteese saakhala yokka bhedaatmaka niyantrananu kaligi untaayi. udaaharanaku, yeastlalo amp samslaeshanha janyuvulu gwanin dwara paelavamgaa anachiveyabadataayi, ayithe zii. emm. pii samslaeshanha janyuvulu adenine dwara prabhaavitam kaavu mariyu maanavulalo implo dehydrogenase samslaeshanha gwanosin samakshamlo anachiveyabadutundi conny adenosine kaadu.