
receiver operating characteristic karv explorer mariyu tester

receiver operating characteristic karv explorer und tester (rasset) anedi jeevakriya dayta setlapai aarosi (receiver operating characteristic) karv vislaeshanhalanu upayoginchi biomarker vislaeshanhanu nirvahinchadaaniki open-access web sarvar. oka praamaanika binary vargeekarana pareeksha (vyaadhi verses vyaadhi) nirvahinchadaaniki mariyu anchanaa vaeyadaaniki rosset pratyaekamgaa roopondinchabadindi. niyantrana). rosset metabolite dayta tablesnu, clinical/observational variables thoo ledhaa lekunda, inputgaa angeekaristundi mariyu eee input daetaanu upayoginchi vistrutamaina biomarker vislaeshanha mariyu biomarker gurtimpunu nirvahistundi. idhi menuu aadhaarita navigation vyavastha dwara panichestundi, idhi garishta roganirdhaarana ledhaa taragati-anchanaa samacharanni kaligi unna clinical variables mariyu/ledhaa metabolitelanu gurtinchadaaniki ledhaa anchanaa vaeyadaaniki viniyogadaarulanu anumatistundi. rasset manueval mariyu semee automated feature empika rendintikee maddatu istundi mariyu biomarker namoonaalo upayoginche biomarkerla sankhyanu taggistune biomarker (la) yokka sunnitatvam mariyu vishishtatanu penche vividha rakaala ganita namuunaalanu svayamchaalakamgaa utpatti cheyagaladu. kramaparivartana pareeksha, hold-avt pareeksha mariyu cross-volidation upayoginchi kottagaa kanugonna biomarkerla naanhyata mariyu drudhatvam yokka kathinamaina anchanaaku kooda rockett maddatu istundi.
nepathyam-biomarker aavishkaranalo aarosi vakratalu.
biomarkerlu saadhaaranamgaa kolichina lakshanaalugaa nirvachinchabadataayi, ivi konni jeeva sthithi ledhaa paristhitiki suuchikalugaa upayoginchabadataayi. avi janyuvulu, rasayanalu, proteins, saareeraka paaraamitulu, imaging dayta ledhaa hystological kolatalu kaavacchu. biomarkerlu oke bhaagaalanu kaligi undavacchu (i.ii. raktamlo glucose) ledhaa bahula bhagalu (asylchornitines vanti biomarker panel). vaidya biomarkerlu 5 pradhana vargaluga vibhajinchabaddaayih 1) roganirdhaarana (meeku vyaadhi ledhaa paristhiti undho ledho gurtinchadaaniki upayogistaaru); 2) rooga niruupana (vyaadhi ledhaa paristhithitho meeru entha baga chestaro nirnayinchadaaniki upayogistaaru); 3) anchanaa (meeku vyaadhi vachindo ledho nirnayinchadaaniki upayogistaaru); 4) samarthatha ledhaa paryaveekshanha (vyaadhitho poradadamlo oka aushadham ledhaa chikitsa entha baga panichestundo nirnayinchadaaniki upayogistaaru) mariyu 5) bahirgatam (meeru oka aushadham, aaharam, visha ledhaa itara rakaala padaarthaaniki gurayyara anie nirnayinchadaaniki upayogistaaru). manchi biomarkerlu manchi sunnitatvaanni (sarigga gurtinchina nijamaina saanukuula amsaala yokka bhinnam) mariyu manchi vishishtatanu (sarigga gurtinchina nijamaina pratikuula amsaala bhinnam) pradarsinchaali. oka paripuurna biomarker ledhaa biomarker panel sunnitamainadi (anaarogya samuuhamlooni prajalandaruu anaarogyamtho unnaarani anchanaa veyandi) mariyu nirdishtamainadi (aarogyakaramaina samuuhamlooni evarainaa anaarogyamtho unnaarani anchanaa veyadam ledhu). ayithe, jeevitamlo konni vishayalu paripuurnamgaa untaayi kabatti, tarachugaa sunnitatvam mariyu vishishtata madhya marpidi untundi. vaidya biomarker adhyayanaalalo receiver operating characteristic (aarosi) karv upayoginchi sunnitatvam mariyu nirdishtatalo eee maarpidini nivedinchadam sarvasaadhaaranam avtondi. aarosi vakrarekhalu x aksham meeda tappudu aavishkarana raetu (1-vishishtata) kuu vyatiraekamgaa, y aksham meeda biomarker yokka sunnitatvaanni chuuputaayi. vividha aarosi vakrarekhala chitram chitram 1loe choopabadindi.
aarosi vakrarekhalu biomarker yokka sarihaddu parimitini (ledhaa vibhajana parimiti) nirnayinchadaaniki ledhaa sunnitatvam mariyu vishishtata yokka saraina kalayika kosam biomarkula kalayikanu nirnayinchadaaniki oka saadhaarana drushya paddhatini andistaayi. aarosi vakrarekha yokka aak (vakrarekha krinda unna praantam) biomarker (ledhaa biomarkerlu) yokka mottam khachitatvam mariyu vibhajana paniteerunu pratibimbistumdi mariyu vividha biomarker kalayikalu ledhaa namuunaalanu poolchadaaniki takshaname upayoginchavacchu. oka niyamam prakaram, aarosi vakrarekha yokka eyusini penchadaaniki evarainaa upayoginche biomarkerlu entha takkuvagaa unte antha manchidi.
metabolomics.
rosset yokka aarosi vakrata utpatti mariyu vislaeshanha pratyaekamgaa metabolomics datasetla kosam roopondinchabadindi. adhika nirgamaamsa vislaeshanhaatmaka rasayana shaastra paddhatula dwara utpatti cheyabadina metabolomics dayta setlu saadhaaranamgaa bahula namuunaalaku bahula viluvalanu kaligi unna pedda maatrikalanu kaligi untaayi. detaloni samuuhaalu ledhaa namuunaala upasamitula madhya polikalo saadhaaranamgaa ekaparivartana vislaeshanha mariyu pakshika kanishta chaturasraalu-vivakshata vislaeshanha (pls-daa) ledhaa maddatu vector yantram (svm) vanti yantra abhyasa vargeekarana vidhanalu vanti bahulaparivartana vislaeshanhanu upayoginche ganaanka vidhanalu untaayi. phalitamgaa, rosset rendu ververu rakaala vislaeshanhaatmaka maadyuullanu andistundi-oka ekaparivartana module mariyu oka bahuparivartana module. yeka-vaividhyamaina moduello oke chararaasulu (tii-pareeksha dwara) moolyaankanam cheyabadataayi mariyu vaati vibhajana paniteeruku (i.ii. aarosi yokka aak), confidences viramalu (ci) mariyu ganinchina optimal threasholdtho sahaa. multivariate moduello moodu ververu paddhatula madhya enchukovachhu-ess. vii. emm (maddatu vector yantram), pii. ell. ess-daa (pakshika kanishta chaturasraala vivakshata vislaeshanha) mariyu yaadruchchika adavulu saraina aarr. oo. sii paniteeru kosam gvakriyalu ledhaa clinical chararaasulanu vargeekarinchadaaniki mariyu enchukoovadaaniki. phalitamgaa vachhe vislaeshanha vaari aarosi vakrata lakshanaala aadhaaramgaa agrashreni paniteeru kaligina bahula-variable modal (lanu) utpatti chestundi. eee module namuunaaku dohadapade mukhyamaina chararaasulanu (clinical chararaasulu mariyu/ledhaa gvakriyalu) kooda andistundi ("aarosi explorer" dwara). icchina biomarker namoonaalo chaerchadaaniki nirdishta chararaasulanu manaveeyamgaa enchukune empikaku kooda rockett maddatu istundi. eee chararaasulanu "aarosi tester" upayoginchi vislaeshimchavachchu. kramaparivartana pareeksha, hold-avt pareeksha mariyu cross-volidation upayoginchi kottagaa kanugonna biomarkerlu ledhaa biomarker panella naanhyata mariyu drudhatvam yokka kathinamaina anchanaaku kooda rockett maddatu istundi.
rasset vividha rakaala rangurangula, journal-siddhamgaa unna graphlu mariyu table utpatti chestundi (sankhyalu 1 mariyu 2 chudandi) mariyu pattikalu (CSV formatt), graphlu (png ledhaa pdf) mariyu prosessing charithratho sahaa anni generate cheyabadina faillanu r filega download cheyadaaniki maddatu istundi (dheenini saadhaarana text filega chadavavacchu). eee krindi suuchanaloe raasetnu upayoginchadaaniki oka tutorial andinchabadindi. saadhanamtho prayogaalu cheyadaaniki sikshana datasetlu rasset websitelo andubaatulo unnaayi.