
photothermal therapy

kantiushna chikitsa (pititi) anedi cancertho sahaa vividha vaidya paristhitula chikitsa kosam vidyudayaskaanta vikiranaanni (chaalaa tarachugaa paraaruna tarangadairghyalalo) upayoginche prayatnaalanu suuchistumdi. eee vidhanam photodynamic therapy yokka podigimpu, dheenilo photosensitizer nirdishta byaand laittho utsaahamgaa untundi. eee kriyaaseelata sensitizernu uttejita sthithiki teesukuvastundi, akkada adhi kampana saktini (vaedi) vidudala chestundi, idhi lakshyamgaa unna kanaalanu champutundi.
photodynamic therapy vale kakunda, photothermal therapyki lakshya kanaalu ledhaa kanajaalaalato sankarshana chendadaaniki oxygen avasaram ledhu. photothermal therapy ekkuva tarangadairghya kaantini upayoginchagaladani prastuta adhyayanalu chuupistunnaayi, idhi takkuva saktivantamainadi mariyu anduvalla itara kanaalu mariyu kanajaalaalaku takkuva hanikaram.
nanoscale padaarthaalu.
prastutam kantiushna chikitsa kosam parisoedhinchabadutunna aasaktigala chaalaa padaarthaalu nanoscale unnaayi. dheeni venuka unna pradhana kaaranaalalo okati oka nirdishta parimaana paridhiloo (saadhaaranamgaa 20-300 nm) kanaalatoe gamaninchabadina merugaina paaragamyata mariyu nilupudala prabhavam. eee shreniloni anuvulu kaniti kanajaalamlo pradhaanyamgaa paerukupoetaayani gamaninchabadindi. kaniti erpadinappudu, daani perugudalaku indhanamgaa undataaniki kotta rakta naalaalu avasaram; kanitulalo/sameepamlo unna eee kotta rakta naalaalu saadhaarana rakta naalaalatoe poliste, paelavamaina shosharasa paarudala mariyu kramarahita, leaky vasculature vanti vibhina lakshanaalanu kaligi untaayi. eee karakalu sariiramlooni migilina bhaagaalato poliste kanitilo konni kanaala gananeeyamgaa adhika saandrataku daariteestaayi.
goaled nanorodes (aanr).
huwang mariyu itarulu. cancer kana imaging mariyu photothermal therapy rendintikee bangaaru nanorodlanu upayoginche saadhyatanu parisoedhimchaaru. rachayitalu bangaaru nanorodla uparitalaaniki pratiroedhakaalanu (anty-egfr monoclonal antibodies) samyogam chesaaru, idhi bangaaru nanorodlanu konni praanaantaka cancer kanaalatoe (hcsc mariyu hock praanaantaka kanaalu) pratyaekamgaa bandhinchadaaniki veelu kalpistundi. bangaaru nanorodlatho kanaalanu podigina taruvaata, kanaalanu vividha saktulatoe vikiranam cheyadaaniki 800 nm tie neelamani lazer upayoginchabadindi. praanaantaka cancer kanaalu vijayavantamgaa naasanam ayyayani rachayitalu nivedinchaaru, ayithe praanaantaka kanaalu haanicheyabadaledu.
aanarlu nir kaantiki gurainappudu, kaanti yokka dolanam chese vidyudayaskaanta kshetram aanar yokka uchita electronlu samishtiga pondikagaa dolanam cheyadaaniki kaaranamavutundi. attala parimaanam mariyu aakaraanni marchadam valla grahinchabade tarangadairghyam maarutundi. kaavalasina tarangadairghyam 700-1000 nm madhya untundi endukante jeeva kanajaalam eee tarangadairghyala vadda opticalga paaradarsakamgaa untundi. anni attalu vaati aakaram mariyu parimaanamlo maarpuku sunnitamgaa unnappatikee, oo nanorodes lakshanaalu vaati podavu mariyu vedalpu ledhaa vaati kaaraka nishpattiki sambandhinchi vaati kolatalalo edainaa maarpuku chaalaa sunnitamgaa untaayi. oka loha enppai kaanti prakaasinchinappudu, enpe vidyut kshetram disalo dvidhruva dolananni yerparustundi. dolanalu garishta sthaayiki cherukunnappudu, eee pounahpunyaanni uparitala plasmone pratidhvani (spr) antaaru. aanrku rendu spram spectrum byaandlu unnaih okati deergha tarangadairghyamto balamgaa unde daani rekhansha dolanala valla sambhavinche nir praantamloo mariyu okati takkuva tarangadairghyamto balaheenamgaa unde viloma electronic dolanala valla sambhavinche kanipinche praantamloo. spr lakshanaalu kanaaniki kaanti shoshana perugudalaku kaaranamavutaayi. aanr kaaraka nishpatti perige koddi, shoshana tarangadairghyam erupugaa maarutundi mariyu kaanti chedaragotte saamarthyam perugutundi. nir dwara uttejitamayye electronlu electron-electron guddukodam dwara shoshana tarvaata twaragaa saktini kolpotayi, mariyu eee electronlu tirigi vishraanti teesukunnappudu, shakti oka phonanga vidudala cheyabadutundi, adhi cancer chikitsalalo cancer kanaalugaa unde attha yokka vaataavaranaanni vaedi chestundi. lazer attapai nirantara tarangam unnappudu eee prakriya gamaninchabadutundi. pulsed lazer light beams saadhaaranamgaa kanaala yokka anp kariginchadam ledhaa ablationku daariteestaayi. nirantara taranga laejarlu pulsed lazer kosam oke pulls samayam kante nimishalu teesukuntaayi, ala laejarlu okesari pedda praantaalanu vaedi cheyagalavu.
bangaaru naano shellu.
bangaaru suukshma kavachalu, bangaaram yokka sannani poratho puuthathoo kuudina silika suukshmakanaalu. pegg linkerla dwara pratiroedhakaalaku (anty-herr2 ledhaa anty-igg) samyogam cheyabaddaayi. bangaaru nanoshellatho skbr3 cancer kanaalanu podigina taruvaata, kanaalanu vikiranam cheyadaaniki 820 nm laejarnu upayoginchaaru. nirdishta antibody (anty-herr2) thoo kalipina bangaaru nanoshellatho podige kanaalu matrame lazer dwara debbatinnaayi. bangaaru nanoshella yokka maroka vargam mruduvaina templetga liposomulapai bangaaru pora. eee sandarbhamlo, aushadhaanni lopala mariyu/ledhaa dvipadaramlo kooda kappavacchu mariyu lazer kaanti dwara vidudalanu prerepinchavacchu.
thermo naano-architecture (tna).
suukshmakanaala madhyavartitvamtho kuudina pititi yokka clinical anuvaadam vaiphalyam pradhanamgaa sareeramlo vaati sthirathvam gurinchi aandolanalaku kaaranamani cheppavacchu. vaastavaaniki, anisotropic suukshma padaardhaala yokka optical pratispandananu vaati parimaanaanni 150 nm varaku penchadam dwara nir praantamloo tune cheyavachu. marovaipu, 10 nm kante ekkuva biodegradable kaani goppa lohala suukshma padaardhaala shareera visarjana hepatobiliary maargam dwara nemmadigaa mariyu asamarthamaina paddhatiloo jarugutundi. moothrapindaala tolagimpu kosam parimiti kante takkuva suukshmakanaala parimaanaanni tagginchadam anedi loha sthirathvaanni nivaarinchadaaniki oka saadhaarana vidhanam, "antey.ii."ultrassmall nanoparticals (yuu. ess. enn. pii. ess), adhe samayamlo garishta kaanti nundi vaedi badilee <5 enn. emm. nanoparticals kosam untundi. marovaipu, visarjinchadagina bangaaru yuu. ess. enn. pii. la uparitala plasmone yuu. vii/kanipinche praantamloo (modati jeevasambandhamaina kitikeelaku dhooramgaa) untundi, idhi pititi loe vaati sambhaavya anuvartanaanni teevramgaa parimitam chestundi.
jeevaadhokaranam chendhe silika nanocapsules loe ponduparachabadina loha yuu. ess. enn. pii. latho kuurpichina ultrassmall-inn-naano nirmaanaalanu upayoginchadam dwara lohala visarjana nir-prerepinchabadina pititi thoo kalapabadindi. "tii" naas anedi samyuktamgaa kalipe mottamodati nivedinchabadina naar-absorbing plasmonic ultrassmall-inn-naano platformlu i) hyperthermiaku anuvaina kantiushna marpidi saamarthyam, ii) bahula kantiushna kramaalu mariyu iii) chikitsa charya tarvaata building blackla moothrapindaala visarjana. eee rojullo, maanava pancreatic adenocarcinoma yokka viluvaina 3dii namuunaalapai tna chikitsa prabhavam anchanaa veyabadindi.
graphane mariyu graphane oxide.
photothermal therapyki graphane aacharaneeyamainadi. elukalapai kaniti pradaesaalanu 5 nimishala paatu vikiranam cheyadaaniki 2 doubleu/sem. mea. 2 shakti saandratatoe 808 nm laejarnu upayoginchaaru. rachayitalu gamaninchinatlugaa, bangaaru nanorodlanu vaedi cheyadaaniki upayoginche laejarla shakti saandratalu 2 nundi 4 doubleu/sem. mea. 2 varaku untaayi. anduvalla, eee nanoscale graphane sheetlaku bangaaru suukshmakanaalatoe photothermally ablet kanitulaku upayoginche shreni diguva chivara lazer shakti avasaram.
2012loe, yang mariyu itarulu. robinson mariyu itarulu nivedinchina nanoscale taggina graphane oxide gurinchi aasaajanaka phalitaalanu chaerchaaru. maroka inn vivo elukala adhyayanam.< eee adhyayanamlo upayoginchina chikitsa chikitsalo nanoscale taggina graphane oxide sheetla vadakam undhi, idhi robinson mariyu itarulu upayoginchina vaatitho daadaapu samanamga untundi. (conny yea kriyaaseela lakshya kramaalu jodinchabadaledu). lakshya kanitulanu puurtigaa naasanam cheyadaaniki nanoscale taggina graphane oxide sheetlanu vijayavantamgaa vikiranam chesaaru. mukhyamgaa, 808 nm lazer yokka avasaramaina shakti saandrata 0.15 doubleu/sem. mea. 2kii tagginchabadindi, idhi gatamlo avasaramaina shakti saandratala kante takkuva parimaanam. eee adhyayanam nanoscale graphane sheetlu mariyu bangaaru nanoradlatho poliste nanoscale taggina graphane oxide sheetla adhika saamarthyaanni pradarsistundi.
samyugma polymerlu (cps).
pii. tii. tii. kantiushna prasarana agentlanu (pii. tii. eah. ess) upayogistundi, ivi kaanti saktini kantiushna prabhavam dwara vaedigaa marchagalavu, kaniti praantam yokka ushnogratanu penchutaayi mariyu tadwara kaniti kanaala kshayakriyaku kaaranamavutaayi. pratyekinchi, aadarsha ptas adhika kantiushna marpidi saamarthyam (pce), adbhutamaina optical sthirathvam mariyu bio compatibility, mariyu sameepa-infrared (Nir) praantamloo (650-1350 nm) lothaina kanajaala vyaapti mariyu jeeva kanajaalaalo Nir kaanti yokka kaneesa shoshana kaaranamgaa balamaina kaanti adhishoshanam kaligi undaali. pii. tii. yea. laloe pradhanamgaa akarbana padaarthaalu mariyu sendriya padaarthaalu untaayi. goppa loha padaarthaalu, carbon aadhaarita suukshma padaardhaalu mariyu itara 2dii padaarthaalu vanti akarbana pii. tii. eah. luu adhika pii. sii. ii mariyu adbhutamaina photostabilityni kaligi untaayi, conny avi jeevaadhokaranam chendavu mariyu anduvalla vivolo deerghakaalika vishapuurita saamarthyaanni kaligi untaayi. chinna anuvu rangulu mariyu samyojita polymerlu (cps) thoo sahaa sendriya pitas manchi jeeva anukuulata mariyu jeevaadhokaranam kaligi untaayi, conny paelavamaina photostability kaligi untaayi. vaatilo, sainain, porphyrine, thalosainin vanti chinna anuvu rangulu, photobleaching mariyu paelavamaina kaniti susampannata saamardhyaaniki gurayye avakaasam kaaranamgaa cancer chikitsa rangamlo parimitam cheyabaddaayi. pedda π−π samyoga asthipanjaram mariyu adhika electron delocalisation nirmaanamtho kuudina samyoga polymerlu vaati balamaina nir shoshana, adbhutamaina photostability, takkuva cytotoxicity, atyuttama pce, jaleeya maadhyamamlo manchi vyaapti, kaniti unna pradaesamloe perigina perukupovadam mariyu deergha rakta prasarana samayam kaaranamgaa pititi saamarthyaanni chuuputaayi. antekakunda, empika chesina mariyu synergistic cancer therapy kosam bahula-kriyaatmaka suukshma padaardhaalanu nirminchadaaniki samyojita paalimarlanu itara imaging agentlu mariyu aushadhaalato sulabhamgaa kalapavacchu.
tumour pititi kosam upayoginche cps loe pradhanamgaa palianilin (paanii), polypyrol (ppi), polytheopene (pith), polydopamine (pda), donar-acceptor (dii-eah) conjugated polymerlu mariyu paalii (3,4-ethylenedioxithiopine): paalii (4-styrenesulphonate) () unnaayi.
photothermal conversion mechanism.
sendriya ptas yokka ushna utpatti kosam kaani vikiranam prakriya uparitala plasmone pratidhvanitho sambandham unna lohaalu mariyu semikandaktarlu vanti akarbana ptas kante bhinnamgaa untundi. chitramlo chuupina vidhamgaa, samyugmita polymerlu modata kaanti vikiranam kinda uttejita sthithiki (s1) sakriyam cheyabadataayi, aapai uttejita sthithi (s1) moodu prakriyala dwara tirigi bhuu sthithiki (s0) ksheenistundih (i) photan (fluorescence), (ii) intersistem crossing, mariyu (iii) naan-radiative sadalimpu (ushna utpatti). endukante s1 yokka eee moodu margalu s0kii tirigi ksheeninchadam saadhaaranamgaa prakaasa-sunnitamaina padaarthaalalo poteegaa untaayi, vaedi utpattini penchadaaniki mariyu kantiushna marpidi saamarthyaanni meruguparachadaaniki kaanti vidudala mariyu vyavasthala madhya daatadam samarthavantamgaa tagginchabadaali. samyugmita polymerla kosam, oka vaipu, vaati pratyaekamaina nirmaanaalu chaalaa tarachugaa antar molecular guddukovadamto molecular sensitizerla closed stocking kuu daariteestaayi, ivi fluorescence mariyu intersistem crossingnu samarthavantamgaa challarchagalavu, tadwara naan-radiative sadalimpu digubadini penchutaayi. marovaipu, monomeric phototherapetic anuvulatho poliste, samyugmita polymerlu vidadeeyadam mariyu photobleaching, ekkuva rakta prasarana samayam mariyu merugaina paaragamyata mariyu nilupudala (epr) prabhavam kaaranamgaa kaniti pradaesamloe ekkuva perukupovadam vanti vatiki vyatiraekamgaa vivolo adhika sthirathvaanni kaligi untaayi. anduvalla, samyoga polymerlu adhika kantiushna marpidi saamarthyaanni mariyu pedda mottamlo ushna utpattini kaligi untaayi. sendriya ptas yokka kantiushna marpidi saamarthyaanni (η) lekkinchadaaniki vistrutamgaa upayoginche sameekaranaalalo okati eee krindi vidhamgaa undih
η = (haδτmax-qs)/i (1-10-aλ)
ikkada h anedi ushna badilee gunakam, a anedi container uparitala vaisaalyam, δτmax antey draavanamloo garishta ushnograta maarpu, aλ antey kaanti shoshana, i anedi lazer shakti saandrata, mariyu qs anedi draavakam yokka kaanti shoshanhatho anubandhinchabadina vaedi.
antekakunda, vividha samarthavanthamaina paddhatulu, mukhyamgaa daata-graheeta (dii-eah) vyuuham, kantiushna marpidi saamarthyaanni mariyu samyojita polymerla ushna utpattini penchadaaniki roopondinchabaddaayi. samyugmita polymerlalo dii-eah assembly vyavastha daata nundi sweekartaku balamaina intermolecular electron badileeki dohadam chestundi, tadwara samarthavanthamaina fluorescence mariyu intersistem crossing samanaanni teesukuvastundi mariyu merugaina ushna utpattini testundi. adanamgaa, electron daata (edd) mariyu electron sweekarta (ea) moityla empikanu marchadam dwara dii-oka samyojita polymerla yokka homo-lumo gyapnu sulabhamgaa tune cheyavachu, tadwara sii. pii. ess yokka nir shoshana mariyu kantiushna marpidi saamarthyaanni meruguparachadaaniki chaalaa takkuva byaand gapto kuudina nirmaanaatmaka paalimarlanu abhivruddhi cheyavachu.
palianilin (paanii).
kaniti pititi kosam nivedinchabadina mottamodati rakaala samyoga polymerlalo palianilin (paanii) okati.
polypyrol (ppy).
polypyrol (ppi) daani balamaina nir shoshana, pedda pce, sthirathvam mariyu jeeva anukuulata kaaranamgaa pititi anuvartanaalaku anukuulamgaa untundi. 808 nm lazer (1 doubleu sem. mea. − 2,5 nimishalu) vikiranam dwara ppi npsto chikitsa cheyabadina kanitulanu samarthavantamgaa tolaginchavacchani vivo prayogaalu chuupistunnaayi. ppy nanosheetlu lothaina kanajaalam ptt kosam Nir II vindolo cancer kanaala vaipu manchi kantiushna kshaya saamarthyaanni pradarsistaayi.
ppy suukshmakanaalu mariyu daani utpanna suukshma padaardhaalanu imaging contrast agentlu mariyu vibhina aushadhaalato kalapavacchu, imaging-guided ptt mariyu synergistic chikitsalo fluorescent imaging, magnetic resonance imaging (mri), photoacoustic imaging (PA), computed tomography (ct), photodynamic therapy (pdt), chemotherapy modalaina vaatitho sahaa multifunctional theranostic applicationlanu nirminchavacchu. udaaharanaku, ultrassmall iron oxide nanoparticals (ionps) nuu bandhinchadaaniki mariyu chivaraku inn vivo mr mariyu paa imaging-guided pititi kosam ionp@ppy npsnu abhivruddhi cheyadaaniki ppi upayoginchabadindi. siti imaging-guided tumour pititi kosam polypyrol (ii-pippi) nanocomposits parisoedhimchabaddaayi.
polytheopene (pth).
polytheopene (pth) mariyu daani utpannaala aadhaarita polymerlu kooda ptt kosam oka rakamaina samyoga polymerlu. polytheopene aadhaarita polymerlu saadhaaranamgaa adbhutamaina kaanti sthireekarana, pedda kaanti-panta saamarthyam, sulabhamaina samslaeshanha mariyu vividha pratyaamnaayaalato sulabhamaina kaaryaacharananu pradarsistaayi.
2-n, n′-bis (2-(ethyl) hexile)-perileen-3,4,9,10-tetra-carboxylic aamlam bis-imidnu thynilvinilline oligomartho anusandhaaninchadam dwara aasaajanaka kantiushna lakshanaalatoo kuudina samyoga copalimer (c3) nuu tayaaru cheyavachu. oral squamous sell carcinoma (oscc) kuu vyatiraekamgaa fluorescence-guided photothermal/photodynamic therapy kosam pegg-pl-sii3-icg nanoparticalsnu pondadaaniki sii3 pegg-pl mariyu indocyanin green (icg) thoo saha-varshapaatam pondindi. biodegradable plaga-pegilated dii. pii. pii. vii (paalii {2,2′-[(2,5-bis (2-hexildesil)-3,6-dioxo-<ii. dii. 1>, 6-tetrahydropyrolo [3,4-sii]-pyrol-1,4-dyle)-diethiophane]-55′-dyle-alt-vinileen) pce 71% (@808 nm, 0.3 W cm−2) thoo paa-guided ptt kosam samyoga polymer. pradhana golusuloni vinailin bandhaalu cps yokka jeevaadhokaranam, jeeva anukuulata mariyu kantiushna marpidi saamarthyaanni meruguparustaayi.
polydopamine (pda).
dopamine anedi sariiramlooni neurotransmitterlo okati, idhi kanaalu preranalanu pampadaaniki sahaayapadutundi. telikapati alkaleen paristhitulalo melanin lanty padaarthaanni roopondinchadaaniki dopamine sweeya-samaharam dwara polydopamine (pda) pondabadutundi. pda balamaina nir shoshana, manchi kantiushna sthirathvam, adbhutamaina jeeva anukuulata mariyu jeevaadhokaranam mariyu adhika kantiushna marpidi saamarthyaanni kaligi undhi. inca, π samyojita nirmaanam mariyu vividha kriyaaseela samuuhaalatoe, fluorescence imaging, mri, siti, pa, target therapy modalaina bahula paniteerunu saadhinchadaaniki vividha padaarthaalatho pdni sulabhamgaa kalapavacchu. dheenini drushtilo unchukuni, pda mariyu daani mishrama suukshma padaardhaalu biomedical rangamlo vistruta anuvartana avakaasaanni kaligi unnaayi.
dopamine-melanin colloidal nanospheres anedi inn vivo cancer therapyki samarthavanthamaina sameepa-paraaruna kantiushna chikitsa agent. vivo loe kantiushna sthirathvam mariyu saamarthyaanni penchadaaniki bangaaru nanorodes, carbon aadhaarita padaarthaalu vanti itara pii. tii. eah. la uparitalampai kooda pii. dii. eah. nii savarinchavachhu. udaaharanaku, keemo-photothermal therapy kosam pda-modified spike goaled nanoparticals (sgnp@pdas) parisoedhimchabaddaayi.
daata-sweekarta (d−a) cps.
aushadha prayojanaala kosam daata-sweekarta (dii-eah) samyoga paalimarlanu parisoedhimchaaru. naano-pisidipitibiti cps rendu moitylanu kaligi untundih 2-ethylhexyl cyclopentadithiophane mariyu 2,1,3-benzotheadiazole. pisidipitibiti nanopartical draavanam (0.115 enji/ml) 808 nm nir lazer (0.6 doubleu/sem. mea. 2) kuu gurainappudu, ushnogratanu 30°sii kante ekkuva penchavacchu. wang mariyu itarulu. dicatopyrolo-pyrol (dipi) mariyu theophane unitlanu kaligi unna naalugu nir-shoshaka dii-oka nirmaanaatmaka samyoga polymer chukkalu (pidats) nuu 65 saatam varaku pisiitoe prabhaavavantamaina kantiushna padaarthaalugaa roopondinchaaru. jhang mariyu itarulu. isoindigo derivative (bbdf) mariyu bithiophane (biti) lanu varusaga ea mariyu edd gaa upayoginchadam dwara pbbdf-biti dii-eah cps nuu nirminchaaru. pbibdf-bt anedi paalii (ethylene glycol)-block-paalii (hexile ethylene fasfate) (empeg-bii-phep) thoo marinta savarinchabadindi, tadwara pbibdf-bt@np ppe nii 46.7% pce thoo mariyu saareeraka vaataavaranamloo adhika sthirathvamtho pondavacchu. yang yokka samuuham pbtpbf-biti cpsnu roopondinchindi, dheenilo bis (5-oxotheono [3,2-bii] pyrol-6-elidine)-benzodifurandione (btpbf) mariyu 3,3′-dedodesil-2,2′-bthophane (biti) unitlu varusaga ea mariyu edigaa panicheestaayi. dii-eah cps 1107 nm vadda garishta shoshana garishta sthaayini mariyu saapekshamgaa adhika kantiushna marpidi saamarthyaanni (66.4%) kaligi untundi. puu mariyu itarulu. eeae (6,6)-phenyl-sii71-byutarik aamlam methyl ester (pisi70bm) mariyu edd pisipidibiti (ess ps) suukshmaprasaram dwara samslaeshanha cheyabadina pisi70bm-pisipidibiti dii-eah cps. wang mariyu itarulu. theophane-fused benzodifurandione-aadhaarita oligo (pii-phenylene vinileen) (tibidopvi) nuu ea unitga mariyu 2,2′-bithio-pheen (diti) nuu edd unitga kaligi unna dii-eah cps tibidopvi-ditini abhivruddhi chesindi. tbdopv-dt cps 1093 nm vadda balamaina shoshananu kaligi untundi mariyu atyanta samarthavanthamaina nir-III kantiushna maarpidini saadhistundi.
pedot pss.
 (pedot pss) tarachugaa sendriya electronlalo upayoginchabadutundi mariyu balamaina nir shoshananu kaligi untundi. 2012loe, liu yokka brundam mottamodata pegilated pedaatnu nivedinchindihi cancer yokka infrared photothermal therapyki daggaragaa unde pss polymeric nanopartical (pedat pss-pegg). pedot pss-pegg suukshmakanaalu vivolo adhika sthirathvaanni kaligi untaayi mariyu deergha rakta prasarana sagam jeevitam 21.4 ± 3.1 gamm. jantuvulalo pititi pareekshinchina motaaduku etuvanti prasamsaneeyamaina dushprabhaavaalanu mariyu 808 nm lazer vikiranam kinda adbhutamaina chikitsa saamarthyaanni choopinchaledu. kaang mariyu itarulu. synthesized magneto-conjugated polymer core-shell mnp@pedot: multimodal imaging-guided ptt kosam pss nanoparticals. inca, pedat pss nps ptaluga matrame kakunda sn38, chemotherapy mandulu doxes mariyu photodynamic agent chlorin ii6 (ce6) vanti vividha rakaala mandulanu load cheyadaaniki aushadha vahakamga kooda panichestundi, tadwara synergistic cancer chikitsanu saadhistundi.

