pilomatricoma

pilomatricoma anedi juttu maatrika nundi utpannamaina nirapaayamaina charma kaniti. eee neoplasms saapekshamgaa asaadhaaranamainavi mariyu saadhaaranamgaa thala, mukham mariyu eguva chivaralapai sambhavistaayi. vaidyaparamgaa, pilomatricomas anedi subcatanius nodule ledhaa systga untundi, idhi gurtinchaleni overling epidermis thoo 0.50 nundi 3 sem. mea. varaku untundi, conny atipedda kesu 24 sem. mea. gaa namodaindi.
pradarsana.
sanghaalu.
turner syndrome, myotonic dystrophy, rubinstein-toybee syndrome, trisomy 9 mariyu gardner syndrome vanti vividha rakaala janyu rugmatalalo pilomatricomas gamaninchabaddaayi. turner syndromelo pilomatricomas praabalyam 2.6% gaa unnatlu nivedinchabadindi.
epidermal inclusion sists mariyu pylomatricoma lanty maarpulatoe kuudina hybrid sists gardner syndromelo padepade gamaninchabaddaayi. gardner syndrome unna pillalalo charmasambandhamaina phalitaalu saadhaaranamgaa peddapregu polyposis kante mundu unnanduna eee anubandham rooga niruupana praamukhyatanu kaligi undhi.
hystologic lakshanaalu.
pylomatricoma yokka lakshana bhagalalo fibrovascular connective tissue yokka "stroma" untundi.
chuttupakkala kramarahita aakaaramlo, "basaloid kanaalu" kaligina lobulated dheevulu (muduru rangulo, gundramgaa ledhaa podavainavi, aspashtamaina kana sarihaddulu mariyu kaneesa cytoplasmtho, kendrakaalu andaakaaraaniki gundramgaa untaayi, lothaina basophilic mariyu saadhaaranamgaa pramukha nucleoli), ivi akasmaattugaa ledhaa kramamga "deyyam kanaalugaa" marutayi (samruddhiga, laetha, eosynophilic cytoplasm, baga nirvachinchabadina kana sarihaddulu mariyu kendra spashtamaina praantam kaligi untaayi, conny anhu padaartham yokka mandamaina jaadalu matrame untaayi), ivi keratinese nundi nirakara "necrosis" gaa maaravacchu.
kanitulalo videshee-shareera pedda kanaalatoe calcificationla uniki saadhaaranam.
vyadhikaaraka.
pylomatricoma anedi episi janyuvulo mutation ledhaa beata-catainin janyuvulo sthireekarana mutation, mutation valla kalige adhika sthaayi beata-catainintho mudipadi untundi. beata-catainin yokka adhika sthaayi kanaala vistarananu penchutundi, kanaala maranaanni nirodhistundi mariyu chivariki neoplastic perugudalaku daariteestundi.

