
ayaskanta badilee

ayaskanta badilee (enti), nmr mariyu mrilo, nuclear spin dhruveekarana mariyu/ledhaa spin pondikanu nucleus yokka oka janabha nundi nucleus yokka maroka janaabhaaku badilee cheyadaanni mariyu eee drugvishayaanni upayoginche paddhatulanu suuchistumdi. ayaskanta badilee yokka khachitamaina nirvachanaaniki sambandhinchi kontha aspashtata undhi, ayithe paina icchina saadhaarana nirvachanam marinta nirdishta bhaavanalanu kaligi untundi. sunna kaani spin unna nmr kriyaaseela kendrakaalanu konni paristhitulalo saktivantamgaa okadaanitoe okati kalapavacchu. nuclear-spin energy-coupling yokka vidhanalu vistrutamgaa vargeekarinchabaddaayi mariyu eee krindi vyasalalo vivarinchabaddaayih koneeya momentum coupling, magnetic diapol-diapol interaction, zhe-coupling, residual diapolar coupling, nuclear overhouser effect, spin-spin sadalimpu mariyu spin saturation badilee. pratyamnaayamgaa, rasayana vyavasthalooni konni kendrakaalu asthiramgaa untaayi mariyu samanam kaani vaataavaranaala madhya marpidi avtayi. eee kesuku marinta nirdishta udaaharana "chemical exchange magnetisation transfer" vibhaagamlo pradarsinchabadindi.
yea sandarbhamloonainaa, ayaskanta badilee paddhatulu rendu ledhaa anthakante ekkuva pratyaekamaina kendrakaala janabha madhya dynamic sambandhaanni pariseelistaayi, janaabhaala madhya shakti maarpidini prerepinchi, aadarsavantamaina nmr prayogamlo kolavavacchu.
rasayana marpidi ayaskanta badilee.
magnetic resonance imaging ledhaa protein solutions vanti macromolecular namuunaala nmr loe, kaneesam rendu rakaala neeti anuvulu, free (bulk) mariyu bound (hydration) untaayi. bhaarii neeti anuvulu aneka yaantrika sthaayila swechhanu kaligi untaayi, mariyu atuvanti anuvula kadalika ganaanka sagatu pravartananu pradarsistundi. eee ekaruupata kaaranamgaa, chaalaa uchita neeti protaanlu atuvanti protanla sagatu larmer frequenseeki chaalaa daggaragaa resonance frequencilanu kaligi untaayi. sarigga pondina nmr varnapatamlo idhi irukaina lorenz rekhagaa (4.8 ppm, 20 sii vadda) kanipistundi. pedda neeti anuvulu kooda pedda anuvulanu kalavarapette ayaskanta kshetraaniki saapekshamgaa dhooramgaa untaayi, antey uchita neeti protaanlu marinta sajatiya ayaskanta kshetraanni anubhavistaayi, dheeni phalitamgaa nemmadigaa viloma ayaskaanteekarana vibhajana mariyu podavaina "t" 2 * avutundi. dheeniki viruddhamgaa, aardreekarana neeti anuvulu sthaanika sthuula anuvulatho vistrutamaina paraspara charyala dwara yaantrikamgaa parimitam cheyabadataayi, anduvalla ayaskanta kshetra asamaanatala sagatu ledhu, idhi vistruta pratidhvani rekhalaku daariteestundi. dheeni phalitamgaa nmr signalnu utpatti chese ayaskaanteekarana vaegamgaa vidadeeyabadutundi mariyu chaalaa takkuva "t" 2 viluvalu (<200 μs) untaayi. t" 2 viluvalu chaalaa chinnavi kabatti, kattubadi unna neeti protanla nundi vachhe nmr signal saadhaaranamgaa mriloe gamaninchabadadu.
ayithe, bandhinchabadina (aardreekarana) janabhalo protaanlanu vikiranam cheyadaaniki off-resonance santrupta palsnu upayoginchadam mobile (uchita) protan pool yokka nmr signalpai gurtinchadagina prabhavanni chooputundi. sthuula ayaskanta vector parimaanam sunnaki cherukune vidhamgaa, spinla janabha santruptamainappudu, nmr signalnu utpatti cheyadaaniki spin dhruveekarana undadu. rekhansha sadalimpu anedi rekhansha spin dhruvanaanni tirigi suuchistumdi, idhi t1 dwara vivarinchina retutho sambhavistundi. ayithe aardreekarana neeti anuvula sankhya gamaninchadagina sanketaanni utpatti cheyadaaniki saripodu, aardreekarana mariyu bhaarii janabha madhya neeti anuvula marpidi aardreekarana janabha yokka lakshanaalanu anumatistundi mariyu pedda mariyu kattubadi unna pradaesaala madhya anuvulu marpidi avtunna retunu kolustundi. ituvanti prayogaalanu tarachugaa santrupta badilee ledhaa rasayana marpidi santrupta badilee (sest) anie pilustaaru, endukante aardreekarana janabha santruptamainappudu pedda mottamlo neeti sanketam taggutundani gamaninchabadutundi. eee paddhatulanu vyatiraeka konam nundi pariseelisthe, aaa ayaskaanteekarana (i.ii. spin polarization) anedi pedda neeti nundi spin-santrupta aardreekarana janaabhaaku badilee cheyabadutondi, idhi nucleus janabha madhya ayaskaantatvaanni badilee chese itara paddhathulatho rasayana marpidi paddhatulanu sambhaavitamgaa ekikrutam cheyadaaniki anumatistundi. signal kshayam yokka paridhi uchita mariyu aardreekarana neeti madhya marpidi retupai aadharapadi untundi kabatti, "t" 1, "t" 2, mariyu protan saandrata vyatyaasaalato paatu pratyaamnaaya viruddha paddhatini andinchadaaniki mt nii upayoginchavacchu.
enty anedi chithrinchabadutunna kanajaalam yokka nirmaana samagrataku oka anirdishta suuchika anie nammutaaru.
mt yokka podigimpu, ayaskanta badilee nishpatti (mtr) medadu nirmaanaalalo asaadhaaranatalanu highlight cheyadaaniki neuroradiologylo upayoginchabadindi. (mtr anedi ("m" o "-" m "t")/"m" o ".)
santrupta pulls kosam khachitamaina frequency offset yokka kramabaddhamaina modulation "z-spectrum" nuu roopondinchadaaniki free-water signalku vyatiraekamgaa plaat cheyavachu. eee saanketikatanu tarachugaa "jedd-spectroscopy" anie pilustaaru.

