
selexipag

uptravi brand paerutoe vikrayinche selexipag, pulmonary arterial hyper tension (paa) chikitsa kosam actillion abhivruddhi chesina aushadham. selexipag mariyu daani kriyaaseela metabolite, act-333679 (ledhaa mre-269, uchita carboxylic aamlam), prostassiclin grahakam yokka agonistlu, ivi pulmonary circulationlo vasodilationku daariteestaayi. idhi noti dwara teesukobadutundi ledhaa sirala dwara ivvabadutundi.
idhi saadhaarana aushadhamgaa andubaatulo undhi.
vyatiraeka suuchanalu.
airopalo, gemphybrogyl vanti kaaleya enjaim saip2sii8 yokka balamaina nirodhakaalatho paatu selexipag vadakam viruddhamgaa untundi, endukante idhi selexipag yokka saandratalanu rettimpu penchutundi mariyu daani kriyaaseela jeevakriyanu 11 retlu penchutundi, idhi marinta pratikuula prabhaavaalaku daariteestundi.
pratikuula prabhavalu.
selexipag yokka pratikuula prabhavalu pulmonary arterial hyper tension kosam upayoginche intravenous prostassiclinlanu pooli untaayi. saadhaarana dushprabhavalalo talanoppi mariyu davada noppi unnaayi. selexipag teesukune vyaktulalo hyper thyroidism pramaadam kooda ekkuvagaa unnatlu gurtinchabadindi.
aushadha shaastram.
charya yokka yantraangam.
selexipag mariyu daani kriyaaseela metabolite chattam-333679 oopiritittula kanajaalam yokka prostassiclin graahakampai panicheestaayi, rendodi 37 retlu ekkuva saktivantamainadi. avi prostassiclin graahakaaniki empika cheyabadataayi. eee graahakamtho bandhinchadam moodu pradhana prabhaavaalaku daariteestundihi dhamanula yokka perigina vasodilation, kanaala vistarana taggadam mariyu platelet aggregation nirodham, ivanni pulmonary arterial hyper tension chikitsalo prayojanakaramgaa untaayi.
pharmacokinetics.
selexipag twaragaa pegu nundi grahinchabadutundi mariyu carboxylesterasela dwara 333679 charya cheyadaaniki pregulu mariyu kaaleyamlo jalavisleshanam cheyabadutundi. sampoorna jeeva labhyata 49 saatam untundi, ekkuvagaa adhika fust-paas prabhavam kaaranamgaa untundi. rakta plasmalo atyadhika saandratalu selexipag kosam okati nundi moodu gantala tarvaata mariyu kriyaaseela metabolite kosam moodu nundi naalugu gantala tarvaata chaerutaayi. prasaranalo unnappudu, rendu padaarthaalalo 99 saatam plasma proteinlaku, antey albumin mariyu alfa-1-assid glycoproteinlaku samaana mottamlo kattubadi untaayi.
kaaleya enjaimlu saip2sii8 mariyu kontavaraku saip3eah4, hydroxylate mariyu kriyaaseela padaarthaanni dealkilate chestaayi, tadwara daanini nishkriyam chestaayi. antekakunda, aakt-333679 anedi yujiti1eah3 mariyu yujiti2bii7 enjaimla dwara glucuronidise cheyabadutundi. selexipag yokka antima ardha-jeevitam 0.8 nundi 2.5 gantalu, kriyaaseela metabolite yokka ardha-jeevitam 6.2 nundi 13.5 gantalu.
charitra.
yuu.ess. phud und drugg administration (fda) selexipag anaadha aushadha hodha manjuru chesindi. dheenini 2015 december 22naa eff. dii. yea. aamodinchindi.
airopalo, eee aushadhaanni 2016 maeloe aamodinchaaru.
samajam mariyu samskruti.
aardhikasaastram.
raayiteelaku mundu USలో eee aushadhaaniki anchanaa dhara rogiki $160,000 nundi $170,000 varaku untundi.

