asaadhaarana trophoblast

asaadhaarana trophoblastlu (evts), maavi yokka vibhina trophoblast kanaala yokka oka roopam. avi invasive messenchimal kanaalu, ivi abhivruddhi chendutunna placental-garbhasaya interfacelo klishtamaina kanajaala connectionnu sthaapinchadaaniki panicheestaayi. itara pradhana trophoblast upa rakam, synceteotrophoblast (sinn) maadirigaane, iviteelu progenitor cytotrophoblasts (sites) nundi udbhavistaayi. vaatini konnisaarlu intermediate trophoblast anie pilustaaru.
garbhasaya godatho sambandham unna garbhastha choreonic villi uparitalampai unna sait kanaala nundi utpannamayye ivi-garbhastha sisuvu mancham vadda-hcla-zii antigennu vyakteekarinchadam praarambhistaayi. asaadhaaranamaina trophoblast (iviti) kanaalu langaru villi nundi valasa vacchi deciduva basalis loki daadi chestaayi. vaati pradhana pani garbhasaya sarpila dhamanulanu punarnirminchadam, idhi sarpila dhamani vyasanni naalugu nundi aaru retlu penchutundi. idhi vaatini adhika-nirodhakata kaligina takkuva-pravaaha naalaala nundi pedda vistarinchina nalaluga maarustundi, ivi manchi perfusion mariyu abhivruddhi chendutunna maviki oxygenationnu andistaayi. dandayaatra nissaramga unnappudu adhi saripodu, dhamanulu vaati dwaaraala vadda antara-villus pradaesamlooki irukainavigaa untaayi mariyu prii-eclampsia, pindam perugudala parimiti mariyu inca puttukaku kaaranam.
iviti anedi takkuva-sanghatana (trophoblastlalo <5 saatam), conny maavilo klishtamaina mariyu bahula-kriyaatmaka, trophoblast yokka upa rakam.
function.
maaya erpadatam mariyu cytotrophoblast pora peragadam mariyu vistarinchadam vanti, distal villus sait kana kaalam saitku bhinnamgaa untundi, idhi chivariki vaeru chesi, interstitial evtsga talli desiduvaaku lothugaa daadi chestundi. eee eevits prasuuti desiduvaaku plaasental villini langaru vestaayi. eee. vii. tii yokka nissara amarika paelavamaina maavi mariyu preaclumpsiatho mudipadi untundi. prarambha placental abhivruddhi samayamlo endovascular iviteelu kooda praanavaayuvu yokka pradhana niyantrakaalu. praarambhamlo, avi hypoxianu nirvahinchadaaniki mariyu rakta perfusionnu nivaarinchadaaniki talli sarpila dhamanulanu plug chestaayi. idhi hysteotrophic (grandhi poeshanha) dasalo prarambha abhivruddhi samayamlo pindam mariyu mavini aakseekarana ottidi nundi rakshistundi. pindam poeshanha hemotrophic (raktam nundi pondina poeshanha) dasaku maaradamtho, eee. vii. tii plugs karigipotayi mariyu talli raktam yokka perfusion praarambhamavutundi, idhi pindam mariyu maavi rendinti marinta abhivruddhini anumatistundi.
nirmaanam.
chivariki extraembrionic plaasental trophoblastluga maare kanaalu trophectoderm nundi udbhavistaayi. paeludu samayamlo trophectoderm lopali kana dravyarashi nundi vidipovadamtho, prarambha trophoblastlu mavini yerparustaayi. taruvaata placental abhivruddhilo, antarleena progenitor sell kaalam saitlu epithelial nundi messenchimal transition (emt) loki velladamtho interstitial mariyu endovascular iviteelu rendoo erpadataayi. eee cellular prakriya nirantaram jarugutundi, endukante sait pora vipareetamaina trophoblastlanu bharti chestundi. maavilo ii. vii. tii. kii sait yokka eah. emm. tii. nii doubleu. enn. tii-aadhaaritamaina transcription phyaaktar tii-sell phyaaktar 4 (tii. sii. eff. 4) dwara balamgaa niyantristaaru. canonical doubluenty signalling margalu aneka diguva abhivruddhi-sambandhita transcription phyaaktar janyu lakshyalanu kaligi untaayi, veetilo tii. sii. eff. 4. endukante placental trophoblastlanu abhivruddhi cheyadam tappanisarigaa canonical amtni anusarinchadu, placental trophoblast-nirdishta hybrid amt anedi pratyeka punaraavrutam anie soochinchabadindi.
jeevasambandhamaina gurtulu.
plaasental trophoblast uparakaalanu prati uparakaaniki pratyaekamaina konni gurtula dwara vaeru cheyavachu. epithelial sait nundi messenchimal iviti kii parivartananu ii-caderine nashtam mariyu enn-caderine labham dwara track cheyavachu. itara placental trophoblastla dwara vyakteekarinchani human leukocyte antigen zii (hcla-zii) vyakteekarana dwara kooda ivitsnu vaeru cheyavachu. plaasentallooni itara trophoblast uparakaalu epithelial kabatti, vimentin mariyu fibronectin vanti messenchimal maarkarlanu kooda gurtinchadaaniki upayoginchavacchu. ayithe, eee gurtulu eeviti kii pratyekamainavi kaavu mariyu maavilooni stromal kanaalanu kooda maraka cheyavachu. trophoblastlu abhivruddhi chendutunnappudu, avi ververu integrinlanu vyaktam chestaayi. saitnu saitnu dwara gurtinchagaliginappatiki, evsvs evsvs balamgaa vyaktam chestundi. krinda vivarinchina prastuta "inn vitro" iviti namuunaalu eee gurtulanu mariyu marakanu vividha sthaayilalo khachitatvamto punaraavrutam chestaayi.
"inn vitro" namuunaalu.
eah. vii. tii. ess anedi maavi yokka klishtamaina cellular upa rakam mariyu vaati panicheyakapovadam aneka garbhadhaarana anaarogyaalato mudipadi unnanduna, avi parisoedhanaku aakarshanheeyamaina amsam. sunnitamaina kanajaalaala nundi eee praathamika kana rakanni pondadam kashtam mariyu asthiramgaa untundi. modati mariyu rendava traimaasikamlo garbha kanajaalam saadhaaranamgaa empika cheyabadina garbhasravala nundi pondaali, dheeniki marinta nih documentation mariyu paryaveekshanha avasaram. maayala nundi vachhe kanajaalam marinta sulabhamgaa andubaatulo untundi, conny prarambha abhivruddhi mariyu dynamicsku sambandhinchina prasnalaku samadhanam ivvadaaniki upayoginchabadadu. placental kanajaalamloni itara kana rakaala nundi trophoblastla vibhajana vidhanaparamgaa kashtamgaa untundi mariyu swachchamaina trophoblast uparakam janabhanu pondadaaniki chaalaa samayam padutundi. appudu, phalitamgaa vachhe praadhamika trophoblast kanaalanu konni rojula paatu matrame kalcharlo unchavacchu. anduvalla, praadhamika plaasental trophoblastlanu roopondinchadaaniki khachitamaina kana rekhalaku adhika demand undhi. amaramaina sell line hetch. tii. aarr-8/ess. vii. enn. oo. nii saadhaaranamgaa eah. vii. tii. lanu roopondinchadaaniki upayogistaaru. kotta bahulasakti gala trophoblast muula kana vyavasthalanu sait nundi hcla-zii + iviti gaa vaeru cheyadaaniki prerepinchavacchu. metrigello culture chesinappudu plaasental organides vyavasthalu kooda invasive ivitini penchutaayi. eee empikalalo prati okkati vaati prayojanam mariyu khachitatvamlo praathamika empikalaku maarutuu untundi. parisoedhanaa brundaalu praadhamika kanaalanu "inn vitro" loe punaraavrutam chese merugaina paddhatulanu abhivruddhi chestune unnanduna, plaasental evits yokka saraina namuunaa eee rangam yokka lakshyamgaa migilipoyindi.

