
kshaminchandi 6

vibhajana lopabhuishta 6 homolog alfa anedi maanavulalo "pardy 6 eah" janyuvu dwara encode cheyabadina protein.
function.
eee janyuvu paar6 kutumbaaniki chendinadi mariyu psd95/disclu-peddavi/jooe1 (pdz) domine mariyu semee-cdc42/ryaak interactive binding (crib) domaintho oka proteinnu encode chestundi. eee kana pora protein bahula-protein sanklishtatalo sabhyudiga asamaana kana vibhajana mariyu kana dhruveekarana prakriyalalo paalgontundi. metastatic carcinomatho anubandhinchabadina invasive phenotypenu vargeekarinche epithelial-tuu-messenchimal transition (emt) loe kooda protein paatra undhi. vividha isopharmlanu encoding chese pratyaamnaaya transcriptional splies vaeriyantlu vargeekarinchabaddaayi.
iteevali adhyayanam prakaram paar6 anedi melanomalo pii. keey. sii-ii. thoo anubandham kaligi untundi, conny pii. keey. sii-jetaatho anubandham kaligi undadu. ancogenic pii. keey. sii-ayota, pii. keey. sii-ii/paar6 marganni niyantrinchadam dwara melanoma kana dandayaatranu prothsahistundi. pkc-i nirodham ledhaa nock down phalitamgaa metastatic melanoma kanaalalo mottam vimentin, foforilated vimentin (s39) mariyu paar6 taggutuu ii-caderine mariyu rova sthaayilu perigayi. eee phalitaalu melanomalo emtnu niyantrinche signalling margalalo pkc-i paalgontunnatlu suuchimchaayi.
paraspara charyalu.
kshamaapanalu eee krindi vaatitho sankarshana chendutayani choopabadindihi

