
ctbp2

c-terminal-binding protein 2, ctbp2 anie kooda pilustaaru, idhi maanavulalo "ctbp2" janyuvu dwara encode cheyabadina protein.
function.
ksheeradaalalo ctbps-ctbp1 mariyu ctbp2-uttamamaina transcriptional corpressorlalo okati. avi saadhaaranamgaa tama lakshya janyuvulanu aapivestaayi. vaaru saadhaarana roopam proline-isolucin-aspertate-lucine-serin (pids muulaamsam) yokka chinna muulaamsaanni kaligi unna kramam-nirdishta dna-binding proteinlaku bandhinchadam dwara deenni chestaaru. vaaru appudu histone modifing enjaimlu, histone deacetylases, histone methylases mariyu histone demethylasesnu niyamistaaru. eee enjaimlu kriyaaseelakatanu tolaginchadaaniki mariyu anachiveta histone gurtulanu jodinchadaaniki kalisi panicheestaayani bhaavistaaru. udaaharanaku, histone deasitylase 1 (hcdc1) mariyu hcdc2 sakriyam chese gurtunu histone 3 acetyl lysine 9 (hetch3keey9esi) nuu tolaginchagalavu, appudu histone methylase zii9eah methyl samuuhaalanu jodinchagaladu, ayithe histone demethylase lysine nirdishta demethylase 1 (lsd1) sakriyam chese gurtunu hetch3keey4emeeni tolaginchagaladu.
ctbps aneka vibhina dna-binding proteinlatho bandhistundi mariyu dna-binding proteinlaku kattubadi unna saha-repressorlatho kooda bandhistundi, avi gaata (pogamanchu) snehitulu. pedda transcriptional complexelanu vantena cheyadaaniki ctbps kooda dimerise cheyavachu mariyu multimyrise cheyavachu. avi pradhanamgaa janyu anachiveta sanklishtatalanu sameekarinchadaaniki anumatinche paranjaanu kaligina proteins kanipistaayi.
sii. tii. bii. pii. ess yokka oka aasaktikaramaina amsam emitante, vaati saamarthyam naad mariyu kontavaraku naad + thoo bandhinchagaladu. idhi kana jeevakriya sthithini grahinchadaaniki mariyu naadh/naad + nishpattilo maarpulaku pratispandanagaa janyuvulanu niyantrinchadaaniki veelu kalpistundani pratipaadinchabadindi. tadanugunamgaa, kovvu jeevasaastramlo sii. tii. bii. pii. ess mukhyamainadigaa kanugonabadindi, idhi pii. aarr. dii. emm. 16, enn. aarr. pii. mariyu phaag2 vanti keelaka proteinlaku bandhistundi.
ctbp1 mariyu ctbp2 madhya pakshika anavasarata kaaranamgaa ksheeradaalalo ctbp proteinla puurti kriyaatmaka paatralanu anchanaa veyadam kashtam. adevidhamgaa, ctbp2 nakout mariyu double nakout elukala prarambha ghaatukam eee proteinlanu tolaginchadam valla cellular prabhaavaala yokka vivaranaatmaka vislaeshanhanu minahaayinchindi. oke oka sii. tii. bii. pii janyuvu unna namuunaa jeevula nundi mukhyamaina phalitaalu veluvaddayi. drosophila" loe ctbp anedi abhivruddhilo mariyu syrcadian layallo paalgontundi. purugu "sii. elegans 'sii. tii. bii. pii. jeevitakaalamlo paalgontundi. syrcadian layalu mariyu jeevitakaalam rendoo jeevakriya sensinglo sii. tii. bii. pii. ess paatraku maddatu ichhe jeevakriyatho mudipadi unnatlu kanipistaayi.
ksheerada ctbp2 janyuvu rendu vibhina proteinlanu encoding chese pratyaamnaaya transcriptsnu utpatti chestundi. paina charchinchina transcriptional repressor (corpressor) thoo paatu, synaptic ribbanlu anie piluvabade pratyeka synapses yokka pradhana bhaagam ayina podavaina isopharm undhi. rendu proteinlalo naad + aadhaarita 2-hydroxiacid dehydrogenesses maadirigaane naad + binding domine untundi. 3 '-anuvaadam cheyani praantamloo oka bhaganni eee janyuvunu chromosome 21q21.3 kuu mapp cheyadaaniki upayoginchaaru; ayithe, janyuvulo marekkadaina ilanti sthaanaalu unde avakaasam undani gamaninchabadindi. paeludu vislaeshanha eee janyuvu chromosome 10loe undani choopistundi.
pratyaamnaaya prothsaahaka viniyogam.
sakasheruka reteinalo, sii. tii. bii. pii. 2 janyuvu retina abhivruddhi samayamlo pratyaamnaaya promoterla nundi lipyantareekarinchabadutundi, idhi sii. tii. bii. pii. 2 transcriptional courgulatornu alaage pedda ribbon synaps scaffolding protein ribnu istundi. <reifer paeru = "doi10.1016/s0896-6273 (00) 00159-8"> </reifer> sii. tii. bii. pii2 locus yokka bahula viniyoga kaaryaacharana avian mariyu primate retina madhya samrakshinchabadinatlu kanipistundi, ribi mirna utpatti epigenetic silencing mechanism dwara abhivruddhi chendadamlo alasyam avutundi. abhivruddhi chendutunna maanava reteinalo, reboy marnah isopharm yokka transcription anedi dna methylation dwara epigeneticalga niyantrinchabadutundi. proximal reboy pramotartho kuudina dna shrenulu dna methylation mariyu eee isopharm yokka aalasya transcription kosam susampannam cheyabadataayi, bahusha cone-raad homeobox (crx) transcription factornu bandhinchadaanni nirodhinchadam dwara. maanava pluripotent stem sell (hetch pii ess sii)-nundi pondina 3 dii retina organoids yokka prapancha transcript vislaeshanha ctpb 2 isopharm yokka prarambha mariyu nirantara vyakteekarananu pradarsistundi, taruvaata abhivruddhi chendutunna maanava kantiloo aalasyamaina reboy vyakteekarananu pradarsistundi. <reifer paeru = "10.1038/s41597-022-01853-x"> </reifer>
paraspara charyalu.
ctbp2 thoo sankarshana chendutundani choopabadindihi

