
interleukin 23

interleukin 23 (ill-23) anedi oka heterodymeric cytokine, idhi oka ill-12bii (ill-12pii40) upaghatakam (idhi ill-12thoo panchukoobadutundi) mariyu oka ill-23eah (ill-23pii19) upaghatakamtho koodi untundi. ill-23 anedi cytokins yokka ill-12 kutumbamlo bhaagam. ill-23 (ill-23 grahakam) kosam kriyaatmaka grahakam ill-12arbita1 mariyu ill-23aarr madhya heterodymer kaligi untundi. 
aavishkarana.
ill-23nii modata robbert castellin mariyu denox research instituteloni sahacharulu ganana, jeevarasaayana mariyu cellular immunology vidhaanaala kalayikanu upayoginchi vivarinchaaru.
function.
ill-23 anedi inflammatory cytokine. idhi tii helper rakam 17 sell (th17 sell) nirvahana mariyu vistaranaku keelaka cytokine gaa choopabadindi. oka th17 samalakshanaaniki dhruveekarana anedi il-6 mariyu tgf-β dwara prerepinchabadutundi, ivi th17 transcription karakam rorγt nii sakriyam chestaayi. ill-23 rorjetnu sthireekaristundi, tadwara tihech17 kanaalu il-17, il-21, il-22 mariyu gm-csf vanti vaati prabhaavavantamaina cytokinlanu vidudala cheyadaaniki veelu kalpistundi, ivi extracellular fungis mariyu bacteria nundi rakshanaku madhyavartitvam vahistaayi mariyu avarodha roganirodhaka saktilo palgontayi. il-23 maadirigaane tihech 17 kanaalapai prabhavalu type 3 sahaja lymphoid kanaalaku vivarinchabaddaayi, ivi il-23 uddeepanapai tihech 17 cytokinlanu churukuga sravistaayi. sahaja killer kanaalu kooda ill-23 grahakanni vyaktam chestaayi. avi perigina interferon-gm sraavam mariyu merugaina antibody-aadhaarita cellular cytotoxicitytho pratispandistaayi. ill-23 kooda sidi4 memory tii kanaala vistarananu prerepistundi (conny naiv tii kanaalu kaadu). daani shotha nirodhaka prabhaavaalato paatu, ill-23 angiogenesisnu prothsahistundi. 
ill-23 pradhanamgaa kriyaaseela dendritic kanaalu, macrophaselu ledhaa monocytela dwara sravistundi. sahajamaina shosharasa kanaalu mariyu γδt kanaalu kooda ill-23 nuu utpatti chestaayi. bii kanaalu bii kana antigen grahaka sanketam dwara ill-23 nuu utpatti chestaayi. namuunaa gurtimpu graheeta gurtinchina antigen uddeepana dwara sraavam prerepinchabadutundi. ill-23 asamatulyata mariyu perugudala swayam pratirakshaka vyaadhulu mariyu cancertho mudipadi untundi. anduvalla idhi chikitsa parisoedhanaku lakshyam. dendritic kanaala dwara ill-23 vyakteekarana marinta thymic stromal lymphopoitin dwara prerepinchabadutundi, idhi psoriatic gayalalo perigina caratinocytes dwara vyakteekarinchabadina proallurgic cytokine. psoriasis yokka vyaadhikaarakamlo, charma dendritic kanaalu nociseptive neuronla dwara ill-23 nuu vidudala cheyadaaniki prerepinchabadataayi. bacterial meningitis samayamlo kooda ill-23 perugutundi, idhi epithelial disregulation mariyu vaapuku daariteestundi.
"mycobacterium avium" upajaatulu "parateuberculosis"-stimulated monocyte-utpannamaina macrophaselu ill-23kii dohadapade vaatilo okati, anduvalla johns vyaadhi unna pasuvulu ill-23nii penchaayi.
ill-23 aavishkaranaku mundu, ill-12 anedi elukala vaapu namoonaalalo vaapu yokka keelaka madhyavartigaa suuchimchadaaniki pratipaadinchabadindi. edemaina, pharmacological digbandham dwara ill-12 paatranu anchanaa vaeyadaaniki uddesinchina aneka adhyayanalu ill-12bini lakshyamgaa chesukunnayi, anduvalla avi anukunnanta nirdishtamgaa laevu. rendu upabhaagaalu kooda il-12loe bhaagamaite oohinchina vidhamgaa, il-12eah paniteerunu addukunna adhyayanalu il-12bini lakshyamgaa chesukunna phalitaalanu ivvaledu. 
ill-12bii kosam adanapu sambhaavya binding bhaagaswaamini kanugonadam anedi ill-12 kosam eee paatranu tirigi anchanaa vaeyadaaniki daariteesindi. multiple sclerosis yokka eluka namuunaa ayina prayogaatmaka swayam pratirakshaka encephalomyelitislo adhyayanalu, gamaninchina vaapuku ill-23 kaaranamani choopinchaayi, gatamlo bhaavinchinatlugaa ill-12 kaadu. tadanantaram, keellanoppulu, pegu vaapu mariyu psoriasis namuunaalatoe sahaa, gatamlo ill-12 chikkukunna roganirodhaka pathology yokka aneka itara namoonaalalo ill-23 vaapu abhivruddhini sulabhataram chestundani choopabadindi. takkuva saandrata kaligina ill-23 oopiritittula kaniti perugudalaku todpadutundi, ayithe adhika saandrata oopiritittula cancer kanaala vistarananu nirodhistundi. chinna-kaani kana oopiritittula cancer unna rogula nundi seeramlo ill-23 mariyu ill-23aarr gurtinchabaddaayi mariyu rooga niruupana seeram markerluga pratipaadinchabaddaayi. il-23 atherosclerosis, hyper tension, bruhaddhamani vibhajana, cardiac hypertrophy, myocardial inforction mariyu teevramaina cardiac gaayam vanti hridaya sambandha vyaadhula purogatini kooda prothsahistundi. medadulo, ill-23 anedi γδt kanaalanu sakriyam cheyagaladu, vaati ill-17 vyakteekarananu penchutundi, idhi shotha pratispandanaku dohadam chestundi mariyu tadwara aakasmika intracerebral raktasrava tarvaata dviteeya medadu gaayamlo keelaka paatra poeshistumdi.
monoclonal antibody mandulu.
inflammatory vyaadhulaku chikitsa cheyadaaniki chikitsa lakshyaalalo ill-23 okati. eee saitokinku vyatiraekamgaa darsakatvam vahinche monoclonal antibody ayina ustekinamabnu konni swayam pratirakshaka paristhitulaku chikitsa cheyadaaniki upayogistaaru. guselkumab anedi ill-23kii vyatiraekamgaa maroka monoclonal antibody. ill-23nii nirodhinchadam valla psoriasis yokka clinical abhivyaktini mandaginchavacchu, idhi parokshamgaa 17 roganirodhaka pratispandana mariyu ill-17 utpattini prabhaavitam chestundi. ill-17eah virodhi ayina ixechizumab, psoriasis chikitsalo guselkumab, tildrakizumab ledhaa risankizumab kante vaegamgaa charya praarambhinchinatlu nivedinchabadindi, ivi ill-23 yokka pii19 upaghatakam yokka nirodhakaalu. ayithe, itara ill-23 nirodhakaalatho poliste risankizumab piasorisku uttama chikitsa phalitaalanu kaligi unnatlu choopabadindi. adnectin-2 ill-23 thoo bandhistundi mariyu ill-23-ill-23aarr binding thoo pootiipadutumdi. 
sanketam.
ill-23 heterodymer grahaka samudaayaanni bandhistundihi pii19 upaghatakam ill-23aarrnu bandhistundi, ayithe pii40 upaghatakam ill-12arbi1nii bandhistundi. grahaka bandham jaanas kines 2 mariyu tyrosine kines 2 kinesla niyaamakaaniki daariteestundi. jaanas kines 2 mariyu tyrosine kines 2 signal mariyu phosphorylate stat 3 mariyu stat 4 nuu transduce chestaayi. ganaamkaalu nucleusloni lakshya janyuvula transcription dimerise chesi activate chestaayi. rorgit vyakteekarana mariyu th17 cytokinla transcription vanti keelaka th17 abhivruddhi lakshanaalaku stat3 baadhyata vahistundi. 

