erythropherone

erythropherone anedi "erf" janyuvu dwara maanavulalo encode cheyabadina protein harmon. erythropherone erythroblastla dwara utpatti avutundi, kaaleyamlo hepsidine utpattini nirodhistundi, tadwara haemoglobin samshlaeshanhaku andubaatulo unna inumu mottaanni penchutundi. asthipanjara kandaraala sravinchina erf daihika jeevakriya homeostasisnu nirvahistundani choopabadindi.
aavishkarana.
eluka "fam132b" janyuvu dwara encode cheyabadina emuka majjalo transcript kanugonabadina elukalalo idhi idhi gurtinchabadindi. maanavulalo homologus janyuvu janyuvu mariyu eee kramam itara jaatulalo samrakshinchabadutundi. protein erythroblastla dwara samslaeshanha cheyabadi sravistundi. eee kramam gatamlo eluka asthipanjara kandaraalalo vyakteekarinchabadindi, dheenini myonectin (ctrp15) anie pilustaaru mariyu lipid homeostasisto mudipadi undhi.
seldin mariyu athani sahacharulu ilaa vraasaaru "myonectin pradhanamgaa asthipanjara kandaraala dwara vyakteekarinchabadutundi mariyu sravistundi... (maa) phalitaalu myonectin anedi glucose ledhaa kovvu aamlam pravaahaala phalitamgaa cellular shakti sthithilo maarpulaku pratispandanagaa asthipanjara kandaraala dwara sravinche poeshaka-pratispandinche jeevakriya niyantrakam anie suuchistunnaayi. aneka jeevakriya sambandhita sravinche proteins (udhaa.zii. adiponectin, leptin, resistine mariyu aarr. bii. pii) mariyu kanajaalaalo avi niyantrinche sanketha margalu oobakaayam sthithilo kramabaddhikarinchabadavu. oobakaayam unna sthithilo myonectin yokka vyakteekarana mariyu prasarana sthaayilalo taggudala adanapu kelareela teesukovadam dwara niyantrinchabadani sanklishta jeevakriya circutrylo maroka bhaganni suuchimchavachchu. saareeraka insulin sunnitatvam mariyu shakti samatulyatapai vyayamam chaalaa kaalamgaa lothaina saanukuula prabhavalanu chooputundani telisinappatikii, antarleena vidhanalu asampuurnamgaa ardham chesukobaddayi. swachchanda vyayamam natakeeyamgaa myonectin yokka vyakteekarana mariyu prasarana sthaayilanu penchutundi, idhi kanaalaloki kovvu aamlam teesukovadam prothsahinchadaaniki saareeraka vyayamam yokka prayojanakaramaina prabhavalalo okatigaa undavacchu."
iron metabolismlo palgone erythroblastlalo utpatti ayye harmon erythropherontho samanamga myonectin myonectin choopabadindi.>
nirmaanam.
maanavulalo erythropherone 28 amaino aamlaala signal peptidetho 354 amaino aamlaala purvagaamigaa lipyantareekarinchabadindi. eluka janyuvu 340 amaino assid proteinnu encode chestundi, idhi 71 saatam okela untundi. tnf-alfa lanty domine unna sii-terminal vadda homology ekkuvagaa untundi. c1q/tnf-sambandhita protein (ctrp) kutumbamlo sabhyudiga, erythropherone oka pratyaekamaina n-terminasto 4-domine nirmaanaanni kaligi undhi. rendu pedda domainlu protein multimerisation prothsahinche chinna, proline-ritch, collagen linker dwara anusandhaaninchabadi unnaayi. erythropherone rendu rendu gurtimpu pradaesaalanu kaligi untundani anchanaa veyabadindi. protein harmon sumaru 35-40 kda baruvu untundi.
function.
erythropherone anedi hepsidinpy daani charyala dwara inumu jeevakriyanu niyantrinche harmon. elukalu mariyu maanavulalo chuupinatlugaa, idhi erythroblastlalo utpatti avutundi, ivi kotta erra kanaalu samslaeshanha cheyabadinappudu vistaristaayi, udaaharanaku raktasraavam tarvaata ekkuva inumu avasaramainappudu (stress erythropoisis anie pilavabade). eee prakriya moothrapindaala harmon erythropoietin dwara nirvahinchabadutundi.
dheeni charya yokka vidhanam kaaleya harmon, hepsidine yokka vyakteekarananu nirodhinchadam. eee prakriya moothrapindaala harmon erythropoietin dwara nirvahinchabadutundi. hepsidinnu anachiveyadam dwara, erfay cellular iron egumati chaanal, pheroportin yokka paniteerunu penchutundi. idhi pregu nundi inumu shoshananu penchutundi mariyu nilva nundi inumu sameekarinchadaaniki daariteestundi, taruvaata kotta erra rakta kanaalalo haemoglobin samshlaeshanhaloo upayoginchavacchu. erythropherone emuka marphogenetic proteinlanu bandhinchadam dwara hepchidin samshlaeshanhanu nirodhistundi mariyu tadwara hepchidin vyakteekarananu niyantrinche emuka marphogenetic protein marganni nirodhistundi.
janyu encoding erythropherone lopam unna elukalalo taatkaalika paripakvata haemoglobin lopaalu mariyu raktaheenata nundi aalasyamgaa kolukovadamto flebotomiki pratispandanagaa balaheenamaina hepsidine anachiveta untaayi.
myonectin gaa daani paatralo, idhi kovvu kanajaalaalu mariyu hepatocytelaloki lipid teesukoovadaanni kooda prothsahistundi.
niyantrana.
erythropherone samslaeshanha anedi erythropoietin daani graahakaaniki bandhinchadam dwara mariyu mariyu signalling marganni sakriyam cheyadam dwara prerepinchabadutundi.
clinical praamukhyata.
maanavulalo clinical praamukhyata spashtamgaa maarutondi. eluka adhyayanaalalo samaantaraala nundi, daani paniteeru sambandhitamgaa unde vyaadhulu undavacchu. talassemia eluka namoonaalo, daani vyakteekarana perugutundi, phalitamgaa inumu adhika bhaaram erpadutundi, idhi kooda maanava vyaadhi yokka oka lakshanam. elukalalo vaapu yokka raktaheenata nundi kolukovadamlo oka paatra choopabadindi mariyu asamarthamaina erythropoisis, deerghakaalika moothrapindaala vyaadhula raktaheenata mariyu iron-refractory iron-lopam raktaheenatato vaarasatvamgaa vacchina raktaheenatalo prameyam soochinchabadindi.
raktamlo erythropherone sthaayilu rakta nashtam ledhaa erythropoietin paripalana tarvaata immunoasse dwara ekkuvagaa unnatlu chuupimchabaddaayi. beata-talassemia unna rogulalo chaalaa ekkuva sthaayilu untaayi, ivi rakta marpidi tarvaata taggutaayi.

