
neuraguline 3

nrg3 anie kooda piluvabade neuraguline 3, neuraguline protein kutumbaaniki chendina neural-susampannamaina sabhyudu, idhi maanavulalo "nrg3" janyuvu dwara encode cheyabadutundi. nrglu anevi epidermal groth phyaaktar yokka suupar familylo bhaagamaina signalling proteinla samuuham, udaaharanaku polypeptide groth phyaaktar vantivi. eee proteinla samuuhaalu 'egf-lanty domine' nuu kaligi untaayi, indulo aaru systeine avasheshaalu mariyu moodu disulfide vantenalu untaayi, ivi systeine avasheshaala ekaabhipraaya kramam dwara anchanaa vaeyabadataayi.
neuregulinlu anevi oke janyuvu nundi pratyaamnaaya spliesing dwara erpadina proteinla yokka vibhina kutumbam; avi epithelial, glial mariyu kandara kanaala perugudala mariyu bhedaanni niyantrinchadamlo keelaka paatralu poeshistaayi. eee proteinla samuuhaalu rommu, gunde mariyu asthipanjara kandaraalalo kana-kana anubandhaalaku kooda sahaayapadataayi. naalugu ververu rakaala neuraguline janyuvulu gurtinchabaddaayi, avih nrg1 nrg2 nrg3 mariyu nrg4. nrg1 isopharmlu vistrutamgaa adhyayanam cheyabadinappatiki, kutumbamloni itara janyuvula gurinchi chaalaa takkuva samacharam andubaatulo undhi. nrglu erbibi3 mariyu erbibi4 tyrosine kines graahakaalato bandhistaayi; avi homodymerlu ledhaa heterodymerluga erpadataayi, ivi tarachugaa erbibi2thoo koodi untaayi, idhi yea ligaandnu bandhinchadaaniki gamaninchabadani koo-receptorga panichestundani bhaavistaaru. graheeta yokka sii-terminal linkpai nirdishta tyrosine avasheshaala phosphorylation prothsahinchadaaniki mariyu kanaantara signalling proteinla paraspara charyalanu prothsahinchadaaniki nrglu erbibi graahakaalato bandhistaayi.
naadii vyavastha abhivruddhi, nirvahana mariyu marammattulo kooda nrglu mukhyamaina paatra poeshistaayi; endukante nrg1, nrg2 mariyu nrg3 kendra naadii vyavasthalo mariyu ghraana vyavasthalo kooda vistrutamgaa vyakteekarinchabadataayi. elukalalo, nrg3 abhivruddhi chendutunna kendra naadii vyavasthatho paatu vayojana roopaaniki matrame parimitam anie adhyayanalu gamaninchaayi; munupati adhyayanalu gunde abhivruddhilo nrg1, arbb2 mariyu arbb4 paatralanu kooda highlight chestaayi. erbibi2, erbibi4 ledhaa nrg1 lopam unna elukalu jatarikalo myocardial trabecula abhivruddhini muginchadam nundi madhya-embriogenesis dasalo chanipotayi. endocardiumlo nrg1 vyakteekarana anedi myocardiumlo erbibi2 mariyu erbibi4 vyakteekarananu sakriyam cheyadaaniki avasaramaina mukhyamaina ligand anie eee phalitaalu dhruveekaristaayi.
function.
neuregulinlu erbibi-kutumba graahakaala yokka ligandlu, ayithe nrg1 mariyu nrg2 erbibi3 mariyu erbibi4 rendintinee bandhinchagalavu mariyu sakriyam cheyagalavu, nrg3 bandham tyrosine phosphorylation prerepistundi mariyu erbibi4 grahaka tyrosine kines yokka extracellular domaintho matrame bandhinchagalavu, conny erbibi kutumba graahakaalaloni itara sabhyulatho kaadu; erbibi2 mariyu erbibi3.
nrg1, pindam cerebral cartex yokka abhivruddhilo keelaka paatra poeshistumdi, idhi cartical sell yokka valasa mariyu sequencingnu niyantristundi. nrg1కii viruddhamgaa, nrg3 janyuvu yokka prii-mrna splissing gurinchi, daani transcriptional profile mariyu medadulooni panitiirutoe paatu parimita samacharam undhi. maanava pindam medadu nundi nrg3 yokka pratyaamnaaya clone cheyabadina isopharm ayina hcfbnrg3 (maanava pindam medadu nrg3; dqu857894) yokka iteevali aavishkarana, erbibi4/paie3keey/eketi1 maargam sahayamtho oligodendrocyte manugadanu prothsahistundi mariyu neurodevelopment mariyu medadu kaaryaacharanalalo nrg3-erbibi4 signalinglo kooda paalgontundi.
nrg1 mariyu nrg3 samaantaraalu anie adhyayanalu velladinchinappatikii, nrg3 yokka egf domine nrg1తoouu 31 saatam matrame samanamga untundi. nrg3 yokka enn-terminal domine indriya mariyu motaru neuron utpanna karakanni pooli untundi; smdf endukante dheeniki aneka nrg1 isomerlaku aapaadinchabadina aiji-lanty mariyu cringle-vanti domainlu laevu. hydropathy profile adhyayanalu nrg3లoouu sravinche proteinlalo saadhaaranamaina hydrophobic enn-terminal signal sequence ledani choopinchaayi, conny dhruvarahita ledhaa chaarj cheyani amaino aamlaala praantaanni kaligi untundi (doubleu66-vii91). smdf loe kanipinche amaino aamlam praantam nrg3 yokka eee dhruvetara pradaesaanni pooli untundi mariyu endoplasmic reticulum pora antataa translocation agentga panichese antargata, aparisubhramaina signal sequensga panicheyaalani pratipaadinchabadindi.
clinical praamukhyata.
iteevali maanava janyu adhyayanalu neuraguline 3 janyuvu (nrg3) nuu vividha rakaala neuro-developmental desorderlaku kaaranamayye sambhaavya pramaada janyuvugaa velladinchaayi, dheeni phalitamgaa schizophrenia, kungubatu abhivruddhi, shraddha lotu sambandhita rugmatalu mariyu janyuvulo nirmaanaatmaka mariyu janyu vaividhyaalu sambhavinchinappudu bipolar desorderlu erpadataayi.
murry mukhyamgaa, "nrg3" janyuvu yokka vaividhyaalu schizophreniaku gurayye avakaasam kaligi untaayi. schizophrenialo palgonna nrg3 yokka isopharm-nirdishta namoonaalalo perugudala nivedinchabadindi, mariyu rs10748842 thoo paraspara charya kaligi unnatlu gamaninchabadindi; nrg3 risk polymorphism, idhi nrg3 transcriptional disregulation anedi molecular risk mechanism anie suuchistumdi.
eee isopharmlu hirshsprung vyaadhitho kooda mudipadi unnaayi.
schizophrenia.
nrg-erbi signalling maargamloni aneka janyuvulu schizophreniaku janyu siddhatalo chikkukunnayi, neuraguline 3 (nrg 3) daani samaantara nrg 1 maadirigaane oka proteinnu encode chestundi mariyu rendoo naadii vyavastha abhivruddhi chendadamlo mukhyamaina paatralu poeshistaayi. autism mariyu schizophrenia vanti itara rogalakshanhaalato gamaninchinatlugaa, edainaa protein kutumbaaniki chendina chaalaa mandhi sabhyulu oke samalakshanamtho, vyaktigatamgaa ledhaa kalisi anubandham kaligi undataaniki adhika avakaasam untundi.
maanava medadu abhivruddhilo nrg3 isopharm vyakteekarana yokka taatkaalika, roganirdhaarana mariyu kanajaala-nirdishta modulation yokka iteevali adhyayanam, 14 vaaraala nundi 85 samvatsaraala vayassu gala 286 saadhaarana mariyu prabhaavita (bipolar ledhaa teevramaina nispruha rugmata) abhyardhula nundi maanava postmortem dorsolateral prefrontal cartexlo nrg3 yokka 4 taragatulanu lekkinchadaaniki qrt-pcr; quantitative polymerase chain reaction vadakanni upayoginchindi. nrg3 yokka prati 4 isopharm class (ii-aivi) maanava neopalium abhivruddhi mariyu vruddhaapyamlo pratyaekamaina vyakteekarana pathaalanu choopinchindani parisoedhanalu gamaninchaayi.

