
c19orf67

upf0575 protein sii19orf67 anedi maanavulalo (homo sapiens) sii19orf67 janyuvu dwara encode cheyabadina protein. sii19orf67 yokka orthologlu aneka ksheeradaalu, konni sareesrupaalu mariyu chaalaa davadagala chepalalo kanipistaayi. vrushanhaalu mariyu rommu kanajaalam minaha sareeram antataa takkuva sthaayilo protein vyakteekarinchabadutundi. idhi vyakteekarinchabadina chota, protein oka function nirvahinchadaaniki nucleuselo sthaanikeekarinchabadutundi anchanaa veyabadindi. atyanta samrakshinchabadina mariyu nemmadigaa abhivruddhi chendutunna duff 3314 praantam aneka alfa helixnu yerparustundani anchanaa veyabadindi mariyu protein paniteeruku keelakam kaavacchu.
janyuvu.
maanavulalo, c19orf67 chromosome 19 yokka mainus strandpy 19p13.12 vadda undhi mariyu 4,163 bays jatala (bp) loe vistarinchi undhi.
eee krindi janyuvulu saanukuula tantuvupai c19orf67 sameepamlo kanipistaayih
eee krindi janyuvulu mainus strandpy c19orf67 sameepamlo kanipistaayih
mrna transcript.
c19orf67 moodu transcript vaeriyantlanu kaligi undhi, ayithe rendava mariyu moodava vaeriyantlu oka encemble vislaeshanha dwara matrame anchanaa veyabaddaayi mariyu prayogaatmakamgaa dhruvikarinchabadaledu. modati rendu rakalu matrame protein-coding transcripts.
modati transcript 1447 bipi kaligi undagaa, rendava mariyu moodava transcript varusaga 751 bipi mariyu 656 bipi kaligi unnaayi. podavaina isopharm yokka paripakva mrna 6 exanlatho roopondinchabadindi.
protein.
maarpu cheyani proteinlo 358 amaino aamlalu untaayi, anchanaa vesina paramaanu baruvu 40kda, chaarj-11, mariyu 5.44 prolinela isoelectric point protein venta kanugonabaddayi, idhi mottam amaino aamlam kramamlo 12.3% gaa untundi. polchadagina maanava proteinlalo 95 saatam kante upf0575loe saatam vaareegaa prolin content ekkuvagaa unnatlu kanugonabadindi. ayithe, maanava proteemotho poliste asparajin protein parimaanam takkuvagaa untundi.
domainlu.
rendu isopharmlu duff3314 nuu kaligi untaayi. function inca baga ardham kaanappatikee, aneka taxalalo parirakshana protein paniteeruku mukhyamainadani suuchistumdi. modati isopharmlo 12 nundi 80 varaku amaino aamlaala nundi punaraavrutam kaani prolin-ritch praantam untundi. eee praantam yokka paniteeru baga ardham kaaledu, conny prolin yokka drudamaina nirmaanam kaaranamgaa helix erpadakunda nirodhinchadamlo idhi paalgontundi.
dviteeya nirmaanam.
oka cross-programme ekaabhipraayam prakaram, upf0575 protein sii19orf67 amaino aamlam kramamlo eee krindi pradaesaalaloo naalugu alfa helix mariyu rendu beata sheetlanu erparustundihi
anuvaadaanantara maarpulu.
sii-terminus savarinchabade avakaasam lenappudu, enn-terminus vadda acetylation sambhavinche avakaasam undhi. amaino aamlalu 18 mariyu 67 vadda oo-glycosylation sambhavistundani anchanaa veyabadindi. anubandha kineslatho paatu aneka sambhaavya phosphorylation pradaesaalu gurtinchabaddaayih
upa kana sthaanikeekarana.
upf0575 protein sii19orf67 kendrakamlo, mukhyamgaa nucleolusnu lakshyamgaa chesukuntundani bhaavistunnaaru.
vyakteekarana mariyu niyantrana.
janyu vyakteekarana yokka niyantrana.
promoter praantam 5 'utr nundi 1,303 bipi eguva bhaagamlo praarambhamai 1,447 bipini kaligi untundani anchanaa veyabadindi, deenivalla 144 bipi 5' utr thoo ativyaapti chendutundi.
foxp1, sokes5, sokes6, sokes4, mariyu enjedf1 vanti aneka transcription karakalu pramotartho bandhinche avakaasam undhi, ivi tarachugaa transcription tagginchadaaniki panicheestaayi. itara janyuvula vyakteekaranaku sambandhinchi, eee transcription karakalu saadhaaranamgaa gunde, oopiritittulu vanti vividha kanajaalaala abhivruddhilo paatra poeshistaayi mariyu prarambha pinda kanaalu mariyu erra rakta kanaala bhedamlo kooda palgontayi.
transcriptional regulation.
c19orf67 yokka paripakva mrna 3 'utr paie oka kaandam loopnu yerparustundani anumaaninchabadindi, idhi transcript yokka 1,296 bipi nundi 1,350 bipi varaku vistarinchi untundi.
kanajaala vyakteekarana.
maanavulalo, upf0575 protein sii19orf67 vrushanhaalu mariyu rommu kanajaalamlo ekkuvagaa vyakteekarinchabadutundi, ayinappatikee idhi kadupu, mastishka valkalam, thyroid grandhi mariyu lalajalam grandhiloo takkuva sthaayilalo kooda vyakteekarinchabadutundi.
aneka kanajaalaalo maanava protemo kante protein utpatti takkuvagaa untundi.
homology.
paralogs.
upf0575 protein sii19orf67 yokka telisina samaantaraalu laevu, ledhaa duf3314 yokka telisina samaantara domainlu kooda kanugonabadaledu.
orthologs.
vividha rakaala ksheeradaalalo upf0575 protein sii19orf67 yokka orthologlu unnatlu kanugonabadindi, ivi mukhyamgaa elukalu mariyu primatelalo baga praatinidhyam vahistaayi. prati sareesrupaala kramamlo orthologlu kooda kanugonabaddayi, conny ksheeradaalato poliste vaati uniki chaalaa takkuvagaa undhi. adhika sankhyalo mariyu vividha rakaala rae-finned chepalaku orthologlu unnatlu kanugonabadindi, ayithe takkuva cartilogenous chepalu aartholaaglanu kaligi unnatlu kanugonabadindi; orthologlatho davada laeni chepalu dorakaledu.
pakshulu ledhaa ubhayacharaalalo orthologlu levani telisindi. akasherukaalu, sileendhraalu, bacteria ledhaa takkuva jaatulaku orthologlu teliyavu.
upf0575 protein sii19orf67 kosam namuunaa artolog sthalamgaa krindi pattikanu roopondinchadaaniki nagnamgaa mariyu paeludu upayoginchabadindi. eee pattika artolagla puurti jabita kaadu, idhi aartolaaglu unna vyavadhini mariyu aaa jaatula vaividhyaanni pradarsinchadaaniki uddesinchabadindi.
paramaanu parinaamam.
upf0575 protein sii19orf67 oka kutumbaanni kaligi untundi mariyu upf0575 protein sii19orf67 yokka parinaamam antataa spashtamaina nakileelu laevu.
janyuvu yokka duff3314 praantam migilina janyuvutho poliste nemmadigaa vidipoyinatlu kanipistundi, idhi aaa praantam proteinlo mukhyamaina paatra pooshinchinanduna aaa praantam suddeekarana empikalo undavacchani suuchistumdi.
clinical praamukhyata.
oka cases studylo, chromosome punarvyavastheekaranala valla tolagimpula kaaranamgaa kolpoyina chromosome 19 looni 29 janyuvulalo sii19orf67 okati. punarvyavastheekaranalu naadii abhivruddhi samasyalu mariyu pravartanaa asaadhaaranatalaku daariteesaayi, ayinappatikee phalitamgaa vachhe samalakshanhaalalo c19orf67 churukaina paatra pooshinchindoo ledho teliyadu. vaerae adhyayanamlo, sii19orf67 thoo sahaa chromosome 19 looni oka bhaagam tolaginchabadinappudu, garbhasaya perugudala parimiti, akaala jananam mariyu kandaraala hypotonia vanti abhivruddhi samasyalu sambhavinchaayi.
c19orf67, aneka itara janyuvulatho paatu, paripakva beata kanaalanu gurtinchadaaniki saadhyamayye markerga upayoginchavacchu.