
cbs domine

molecular biologylo, sii. bii. ess. domine anedi bacteria nundi maanavula varaku anni jaatulalo proteinla shrenilo kanipinche protein domine. idhi 1997loe mottamodata samrakshinchabadina kramam praantamgaa gurtinchabadindi mariyu systathionine beata synthase paeru pettabadindi, idhi proteinlalo okati. sii. bii. ess. domainlu inosine monophosphate dehydrogenase, voltage gated chloride chhaanals mariyu ampere-activated protein kines (ampere) vanti aneka rakaala itara proteinlalo kooda kanipistaayi. ampere mariyu eah. tii. pii. ledhaa ess-adenosylmethionine vanti adenosyl samuuhaalatoe bandhinche anuvulaku pratispandanagaa anubandha enzymatic mariyu transporter domainla karyakalapalanu sii. bii. ess domainlu niyantristaayi.
nirmaanam.
cbs domine beata-alfa-beata-beata-alfa dviteeya nirmaana namuunaatoe koodi untundi, idhi oka globular trutheeya nirmaanamloo muduchukundi, idhi oka vaipu rendu α-heliklatho moodu-stranded antiperallel β-sheetnu kaligi untundi. cbs domainlu ellappuduu protein shrenulalo jatalalo kanipistaayi mariyu eee domainla yokka prati jatha vaari β-sheetla dwara cbs-jatha ledhaa batman domine anie pilavabade nakilee diameric amarikalo gattiga anubandhinchabadataayi. eee sii. bii. ess domine jatalaku thala-nundi-thala (i.ii. pdb sankethaalu,) ledhaa thala nundi thoka (i.ii. pdb sankethaalu,) disk lanty sanklishta nirmaanaanni yerparustundi. alaa cheyadam dwara, avi canonical ligand binding praantaalanu yerparustaayi. suutrapraayamgaa, canonical binding saitla sankhya anuvu lopala unna sii. bii. ess domainla sankhyatho saripolutundi mariyu saampradayakamgaa sii. bii. ess domine prakaram lekkinchabadutundi, indulo prati rakshita aspartate avasheshaalu nucleotidela ribojto sankarshana chendutaayi. ayithe, eee kuharalanni tappanisarigaa nucleotidelanu bandhinchavu ledhaa kriyaatmakamgaa undakapovachhu. iteevala, ampere kosam oka kaani canonical sait kooda "m" nundi protein mj1225 loe vivarinchabadindi. jannashi, "ayithe daani kriyaatmaka paatra ippatikee teliyadu.
ligand binding.
cbs domainlu ampere mariyu eah. tii. pii, ledhaa ess-adenosylmethionine vanti anuvulalo adenosyl samuuhaalatoe bandhistaayani choopabadindi, conny avi mg2 + vanti loha ayaanlanu kooda bandhinchavachhu. eee vibhina ligandlanu bandhinchina taruvaata cbs domainlu anubandha enzymatic domainla karyakalapalanu niyantristaayi. eee niyantranalo antarleenamgaa unna paramaanu vidhanalu kevalam spashtam cheyabadatam praarambhinchaayi. prastutaaniki, rendu ververu rakaala yantraamgaalu pratipaadinchabaddaayi. modatidi ligand yokka nucleotide bhaagam protein nirmaanamloo etuvanti maarpunu prerepinchadani, binding sait vadda sthiravidyutho kuudina sambhaavyata adenosine nucleotide binding yokka atyanta mukhyamaina aasti anie perkondi. eee "sthira" pratispandana shakti chaarj dwara niyantrana prayojanakaramgaa unde prakriyalalo paalgontundi. dheeniki viruddhamgaa, rendava rakam yantraangam ("dynamic" gaa suuchimchabadutumdi) snayuvu bandhampai protein nirmaanamloo naatakeeya conformational maarpulanu kaligi untundi mariyu "thermus thermophilus" nundi mg2 + transporter mgte yokka cytosolic domine kosam nivedinchabadindi, teliyani function protein mj0100 nundi "m". jannaschi "mariyu" clostridium perfringens "pyrophosphate yokka niyantrana praantam.
anubandha domainlu.
cbs domainlu tarachugaa itara domainlanu kaligi unna proteinlalo kanipistaayi. eee domainlu saadhaaranamgaa enzymatic, membrane transporterlu ledhaa dna-binding domainlu. ayithe, kevalam sii. bii. ess. domainlanu kaligi unna proteins kooda tarachugaa kanipistaayi, mukhyamgaa procariotlalo. eee swatantra sii. bii. ess. domine proteins itara proteinlatho bandhinchinappudu sanklishtatalanu yerparustaayi, avi kineslatho sankarshana chendutaayi mariyu niyantristaayi.
utparivartanalu vyaadhiki daariteestaayi.
konni maanava sii. bii. ess. domine kaligina proteinlalo utparivartanalu janyu vyaadhulaku daariteestaayi. udaaharanaku, systathionine beata synthase proteinlo utparivartanalu homosystinuria () anie piluvabade jeevakriya yokka vaarasatva rugmataku daariteestaayi. ampk enjaim yokka gaama subunitlo utparivartanalu wolf-parkinson-white syndrome () thoo kutumba hypertrophic cardiomayopati kii daariteestaayani choopabadindi. impd enjaim yokka sii. bii. ess domainlalo utparivartanalu kanti paristhiti retinities pigmentosaku () daariteestaayi.
manavulaku aneka voltage-gated chloride chaanal janyuvulu unnaayi, veetilo anekam cbs domainlalo utparivartanalu janyu vyaadhulaku kaaranamani gurtinchabaddaayi. clcn1loe utparivartanalu myotonia () kii daariteestaayi, clcn2loe utparivartanalu idiopathic generalised epilepsy () kii daariteestaayi, clcn5loe utparivartanalu dents vyaadhiki daariteestaayi (), clcn7loe utparivartanalu bolu emukala vyaadhiki () daariteestaayi, mariyu clcnkblo utparivartanalu barter syndrome () kii daariteestaayi.

