
jink transporter zip12

draavakam vaahaka kutumbam 39 sabhyudu 12 anedi maanavulalo slc39eah12 janyuvu dwara encode cheyabadina protein.
function.
jink anedi vandalaadi enjaimlaku avasaramaina cofactor. idhi protein, nucleic aamlam, carbohydrate mariyu lipid jeevakriyatho paatu janyu pratilekhanam, perugudala, abhivruddhi mariyu bhedam yokka niyantranalo paalgontundi. zip12 anedi jink transporterla nirmaana lakshanaalanu choopinche proteinla upakutumbaaniki chendinadi.
praathamika lakshanaalu.
jink transporter zip12 anedi draavakam vaahaka 39 member 12 (slc39eah12) janyuvu dwara encode cheyabadina protein. zip12 anedi lohalanu ravana chese jerdarti-lanty, irt-lanty proteinla (gyps) kutumbamlo bhaagam. zip 12 anedi janyu rugmata acrodermatitis enteropathicalo utparivartana chendina idhe vidhamaina ravana samstha zip 4 thoo chaalaa daggari sambandham kaligi untundi. maanava zip 12 daani amaino aamlalalo 31 saatam maanava zip 4 thoo vaati rakshita praantaala madhya panchukuntundi. maanavulalo zip 12 yokka rendu pradhana splies rakalu unnaayi, ivi 691 mariyu 654 amaino aamlaala podavu kaligi untaayi. zip12 yokka eee 2 rakaala podavulalo vyatyaasam inn-frame exannu cherchadam ledhaa minahaayinchadam valla vastundi.
zip 12 proteinlo sakasherukaalalo (ksheeradaalu mariyu maanavulato sahaa) itara zip transporterlalo samrakshinchabade aneka muulakaalu untaayi. zip12 enimidi transmembrane domainlanu kaligi undhi mariyu transmembrane praantaalalo hystidine avasheshaalanu kaligi undhi, ivi naalugu mariyu aidu cellular membranela antataa jink ravaanaaku avasaramani nammutaaru. zip 12 plasma pora vadda untundi mariyu jink ayaanlanu kanam velupali nundi lopali bhaagaaniki ravana cheyagaladu.
maanavulu, reasus kothulu, pillulu, kukkalu, elukalu mariyu elukalatho sahaa elukalu, kollu vanti pakshulu mariyu "genopus lavis" mariyu "genopus tropicalis" vanti kappalatho sahaa sakasherukaalalo slc39eah12 janyuvu samrakshinchabadutundi. japanese medaca, nail tilapia mariyu european seabas vanti konni chepalalo slc39eah12 janyuvu untundi, conny gbrafishlo slc39eah12 janyuvu undadu. zip 12 jinknu ravana cheyagaladani choopabadindi, zip 12 jink kakunda itara lohalanu ravana cheyagaladani prastutam etuvanti aadharalu laevu. zip 12 aneka kanajaalaalo vyakteekarinchabadutundi mariyu mukhyamgaa medadu mariyu kantiloo ekkuvagaa untundi. elukalalo, zip 12 mrna clomum loe kanugonabadaledu.
eluka naraala kanaalalo neurite podigimpu mariyu mitochondrialo paatra.
mouse neuro-2eah kanaalu mariyu praadhamika mouse neuronlalo, neurite podigimpuku zip 12 avasaram. neuritelu anevi bhedam samayamlo neural sell yokka sell boddy nundi vachhe anchanaalu, mariyu neuritelu oxanlu ledhaa dendraitlanu suuchimchavachchu. kana sareeram nundi neuritelanu vistarinchadaaniki neural sell kuu zip 12 elaa mukhyamo adhyayanam cheyadaaniki, parisoedhakulu zip 12 mrnnu ksheeninchadaaniki mariyu zip 12 proteinnu tagginchadaaniki rna jokyanni prerepinchadaaniki short hair pinn rna (srna) nuu upayoginchaaru. zip12 nii pratyaekamgaa lakshyamgaa chesukuni shranato sankraminchina neuro-2eah kanaalu mariyu praadhamika eluka neuronlalo, neural kanaalu chinna neuritelanu kaligi untaayi. zip12 nuu daatavesi, cellular poranu daatagala jink ianophore thoo kanaantara jinknu penchadam dwara zip12 ksheenatatoo kanaalalo neurite podigimpunu punaruddharinchavachhu.
tadupari adhyayanamlo, chrisper-madhyavartitva janyuvu savarananu upayoginchi lakshyamgaa zip12 utparivartanalu kaligina neuro-2yea kanaalu kooda bhedam mariyu mitochondrial panicheyakapovadam samayamlo chinna neuritelanu kaligi untaayi. adanamgaa, zip 12-tolaginchina kanaalu cellular swaasakriyanu tagginchaayi, idhi mitochondrial paniteeru yokka kolata. zip12 laeni kanaalalo, mitochondria yokka electron ravana golusuku nirodhakaalu ayina rotinone mariyu sodiyam azide dwara neuro-2eah yokka neurite podigimpu ekkuvagaa prabhaavitamavutundi. zip12-tolaginchina kanaalu kooda superoxide utpattini penchutaayi mariyu adhika aakseekarana nashtanni kaligistaayi, ivi balaheenamaina mitochondrial paniteeruku anugunamgaa untaayi. zip 12-tolaginchina kanaalanu alfa-tocopherol (vitamin ii), mitok ledhaa mitotempo vanti antioxidantlaku bahirgatam cheyadam valla neurite podavunu punaruddharinchavachhu, idhi zip 12 laeni kanaalalo unde aakseekarana nashtam kungubatu neuritelaku daariteestundani suuchistumdi.
genopus tropicalis" yokka prarambha naadii vyavastha abhivruddhilo paatra.
zip 12 naadii vyavastha abhivruddhilo "genopus tropicalis" yokka mundari medadu, madhya medadu mariyu kantiloo untundi. neural tube moosivese samayamlo puurva naraala randhram vadda kooda zip 12 untundi. zip 12 mrna neural tube loe kendrikrutamai untundi, mariyu zip 12 vyakteekarana migilina pindamtho poliste neural tube loe ekkuvagaa untundi. genopus tropicalis" pindam abhivruddhiki zip12 elaa avasaramo adhyayanam cheyadaaniki, parisoedhakulu zip12 pindaalanu ksheeninche antisense marpholino oligonucleotidelo pindaalanu inject chesaaru. zip12 yokka anuvaada prarambha pradaesaanni lakshyamgaa chesukuni marpholinolatho inject cheyabadina pindaalalo, pindaalu puurva naraala randhram vadda asampoorna naadii gottam moosivesi, taruvaata pinda maranam kaligi untaayi. zip12 spliesingnu marche mariyu daani paniteerunu debbatise marpholinolatho inject cheyabadina pindaalu nemmadigaa neural tube moosivetanu kaligi untaayi, tarachugaa kallu undavu (anopia anie pilustaaru), mariyu neural tube moosivesina ventane pinda maranaaniki lonavutaayi.
maanava medadu mri namuunaalapai prabhavam.
yuke biobankloni vishayaala nundi janyu-vistruta anubandha adhyayanalu (zii. vii. eah) mariyu exome sequencing zip 12 looni janyu bahuroopata mariyu utparivartanalu maanava medadulooni marchabadina grahanaseelata baruvutho kuudina imaging teevrata mariyu tii1 faast magnetic resonance imaging (emm. aarr. ii) thoo mudipadi unnayani chuupistunnaayi. slc39eah12 sameepamlo unna polymorphisms (rs10430577, rs10430578) anevi lead single nucleotide polymorphisms (snps), ivi caudate, putamen mariyu polydamlo maarina swamri teevratatoo mariyu putamenlo tii1 faast mritho ekkuvagaa sambandham kaligi untaayi. vislaeshanha cheyabadina kanajaalaalo loha padaarthaaniki grahanaseelata baruvutho kuudina ayaskanta pratidhvani imaging sunnitamgaa untundi. chainees chitteluka andaasaya (choe) kanaalalo kolichinappudu anubandha missense zip12 utparivartanalu (rs10764176, rs72778328) jink ravana karyakalapalanu tagginchaayi. ayithe, zip 12 polymorphisms mariyu utparivartanala valla maanava medadulo maarpula prabhavam prastutam teliyadu.
hypoxia-prerita pulmonary hyper tension loe paatra.
hypoxia ksheerada pulmonary naalaala endotheliumlo zip 12 yokka vyakteekarananu prerepistundi. zip 12 prerana valla pulmonary vascular smooth kandaraala kanaala vistarana mariyu gattipadatam jarugutundi, idhi pulmonary hyper tensionku daariteestundi. jhaavo mariyu itarulu. hypoxia-prerita pulmonary hyper tension kuu nirodhakata kaligina matsyakaara 344 (eff344) elukalu mariyu haani kaliginche wistar kyoto (dablyuke) elukala madhya janyuparamaina santanotpatti dwara zip12 nuu baadhyataayutamaina janyuvugaa gurtinchaaru. nirodhakata laeni vai elukalatho daatina nirodhakata gala eff344 elukalu subcongenic jaatulanu utpatti chestaayi, mariyu pulmonary naalaala hypoxic pratispandanato yea janyuvulu saha-vidipothayo mariyu pulmonary hyper tensionku sunnitatvaanni nirnayinchadaaniki parimaanaatmaka lakshanam loki (qtl) vislaeshanha upayoginchabadindi. eff344 elukalalo zip12 frame shift mutation proteinnu kattiristundi mariyu pulmonary endothelial smooth kandara kanaala dwara cellular jink teesukoovadaanni taggistundi. jink vaeli kendrakaala dwara slc39eah12 (zip12) janyuvunu lakshyamgaa tholaginchadamtho elukalalo hypoxia-prerita pulmonary hyper tensionku idhe vidhamaina nirodhakata gamaninchinappudu baadhyataayutamaina janyuvugaa zip12కii adanapu maddatu choopabadindi. elukalatho paatu, pasuvulu mariyu maanavulu kooda hypoxic vaataavaranamloo unchinappudu perigina zip 12 proteinnu chuuputaaru, idhi hypoxiacu perigina zip 12 protein yokka pratispandana vividha ksheeradaalalo kanipistundi. oka hypoxia pratispandana moolakam (hcre) oka slc39yea12 intron lopala untundi, idhi hypoxic paristhitulalo zip12 vyakteekarananu penchutundi. maanava vascular endothelial mariyu mruduvaina kandara kanaalanu upayoginchi oka pratyeka adhyayanamlo, zip 12 vyakteekarana tepen dwara kanaantara jink chelation tarvaata perigindi.
schizophreniatho anubandham.
zip 12 mariyu schizophrenia madhya anubandhalu nivedinchabaddaayi. zip12లoouu naan-coding polymorphism schizophrenia unna rogulalo ekkuvagaa unnatlu varninchabadindi, ayithe eee kanugonadam itara adhyayanaalalo inca punaraavrutam kaaledu. janyu-vistruta suukshma arrelu mariyu post maartam medadu kanajaalaanni upayoginchi chesina maroka adhyayanamlo, schizophrenic vishayaala nundi medadula mundu lobe, unnata mundu gyrus mariyu takkuva mundati gyrus loe jipa 12 mrna samruddhiga unnatlu parisoedhakulu kanugonnaru. schizophrenia unna rogula medadullo zip12 yokka rendu splies variantla yokka adhika vyakteekarana kanugonabadindi.
aatijaaniki saadhyamaina link.
autism kosam utparivartanalu mariyu slc39eah12 looni coppy number vaividhyaalu nivedinchabaddaayi, ayinappatikee janyu vaividhyam autism pramaadaaniki dohadam chestundo ledho aspashtamgaa undhi. aatijamtho unna hohn chainees subjectlalo coppy number vaividhyaalanu anchanaa vese oka adhyayanamlo, oka vyaktiki slc39eah12లoouu heterozygus tolagimpu undhi. maroka adhyayanamlo, oka autistic subjectuku slc39eah12 yokka oka kaapeelo akaala stop codan kanugonabadindi.
cancertho sambhaavya anubandhalu.
zip 12loe marchabadina vyakteekarana mariyu utparivartanalu vividha cancerlalo kanugonabaddayi. esophagial adenocarcinoma unna 145 mandhi rogulalo, mottam exome sequencing 12 mandhi rogulaku kanitulalo zip 12 missense utparivartanaalu microsatalite asthirataku pratikuulamgaa unnayani kanugonnaru. annavahika adenocarcinomapy pratyeka adhyayanamlo zip12లoouu coding utparivartanalu kooda kanugonabaddayi. vividha cancerlalo zip 12 vyakteekaranalo thedaalu nivedinchabaddaayi. pareekshinchina rogulalo kaneesam sagam mandhi nundi naan-small sell oopiritittula cancer biopseed kanajaalaalo zip 12 mrna penchabadindi. praanaantaka ksheerada kana rekha mcf10a thoo poliste rommu cancer rekhalalo t47d mariyu mda-mb-233loe zip12 protein samruddhi takkuvagaa undhi.
zip 12 yokka itara sanghaalu ledhaa vidhulu.
adanapu vyaadhulu ledhaa saareeraka vidhulatho zip 12 yokka anubandhalu nivedinchabaddaayi. broiler maga kodipillalo, chinna pregu yokka oka praantamaina dudenumlo zip 12 mrna vyakteekarana, salmonellatho noti savaaluku pratispandanagaa taggutundi. zip 12 mrna mariyu protein, assits syndrome tarvaata intravenous cellulose micropartical injection dwara kolla oopiritittulu mariyu kaaleyamlo perigayi. jink-lopam tii-kanaalaku jinknu punaruddharinchadam zip 12 vyakteekarananu prerepistundi, idhi roganirodhaka vyavastha dwara cytokine utpattini prothsahinchavachhu. 2 ververu aavu jaatulalo parimaanaatmaka lakshanam loki (qtl) mappingnu upayoginchi, slc39eah12 (zip12) anedi aada chainees mariyu nordic holstein aavulalo santanotpattini prabhaavitam chese abhyardhi janyuvu kaavacchu. cumulus kanaalatoe poliste zip 12 mrna eluka andakosalalo samruddhiga untundi, idhi zip 12 punarutpatti mariyu santanotpattilo paatra pooshinchavacchani suuchistumdi. gurraalapai janyuparamaina anubandha adhyayanam (zii. vii. eah) slc39eah12లoouu antarleena bahuroopata arabia gurraalalo orpu racing panitiirutoe mudipadi undhi. upavaasam chese glucose anedi slc39eah12 janyuvulooni rendu bahuruupatalatoe mudipadi undani oka adhyayanam nivedinchindi, ayithe eee phalitaalu itara adhyayanaalalo dhruvikarinchabadaledu mariyu clomum loe zip12 vyakteekarana kanugonabadaledu.

