
pleakhg2

plextrin homology domine kaligi, kutumbam zii member 2 (pleckg 2) anedi maanavulalo "pleckg 2" janyuvu dwara encode cheyabadina protein. dheenini konnisaarlu arhgef42, flj00018 anie vraayabadutundi.
pleckg2 protein anedi sumaru 1300 amaino aamlaalatoe kuudina bhaarii protein, 130 kda mariyu daani nirmaanam yokka enn terminus sameepamlo dbl homology (dehetch) domine mariyu plextrin homology (pihech) domine kaligi untundi. dehetch domine anedi gwanine nucleotide marpidi kaaryakalaapaalaku baadhyata vahinche domine, idhi roow kutumbamloni chinna gtpace (rhogtpase) paie gdpni gtpga maarustundi, mariyu eee domine unna pleckg2 kooda roow-nirdishta gwanine nucleotide marpidi karakamga (rhogef) panichestundi.
rhogtpase yokka kriyaaseelata actin cytoskeleton nuu punarnirmistundi mariyu kana padanirmaana saastraanni maarustundi, kabatti pleckg 2 anedi rhogtpase mariyu actin punarnirmaanam dwara kana chalanasheelata mariyu neuronla neuronla network abhivruddhiki dohadam chestundi (taruvaata chudandi).
cloning.
retroviral transduction dwara utparivartana chendina recombinant bxh2 mariyu akxd inabrade elukalu adhika frequency vadda myeloid leukemia, b sell mariyu t sell leukemianu abhivruddhi chestaayi.
2002loe, himmel mariyu itarulu., teevramaina milogenous leukemia yokka eee namuunaanu upayoginchindi mariyu oka kotta dbl kutumbam gwanine nucleotide marpidi karakam janyuvu ivi 24 anie piluvabade retroviral up take sait diguva bhaagamlo undani choopinchindi. vaaru eee janyuvuku clg anie paeru pettaru. hemmel mariyu sahacharulu clgni clone chesi, maanava chromosome 19 chromosome 19q13.1 praantamloo unna pleckg2 thoo homologyni chuupimchaaru. eee pariseelanala nundi vaaru teevramaina myeloid leukemiatho anubandhaanni etthi chuupaaru.
vidhulu.
hemmel mariyu itarulu prachurinchina oka patrikalo.2002loe, vaaru clg yokka dehetch-eff domine kaligi unna nirmaanam sidisi42 yokka gwanine nucleotide maarpidini prothsahistundani, ayithe ryaak1 ledhaa rova yokka gwanine nucleotide maarpidini prothsahinchadani chuupimchaaru. adanamgaa, nihta3 kanaalalo dehetch-eff domainlu ledhaa puurti-nidivi clg pravesapettabaddaayi mariyu parivartana jarigindi.
taruvaata, yueda mariyu athani sahacharulu heck 293 kanaalalo puurti-nidivi gala maanava plekh 2 yokka vyakteekarana nirmaanaanni pravesapettaaru. eee kanamlo trimeric zii protein yokka gbtg upaghatakam neerugaa pleckg2 thoo sankarshana chendindi. ueda mariyu sahacharulu pleckg2 gbg dwara sakriyam cheyabadindani mariyu pleckg2 rhogtpase yokka ryaka1, sidisi42 nuu sakriyam chesi kana padanirmaana maarpuku dohadam chestundani kooda chuupimchaaru.
2013loe, ranne mariyu itarulu., jurkat tii kanaalatoe sahaa aneka leukemia kana rekhalalo plekhg 2 paiki edigindani choopinchindi. adanamgaa, ryaak mariyu sidisi42 yokka gpcr signal-aadhaarita kriyaaseelata actin polymerisation dwara lymphocytela chemotoxisnu niyantristundani vaaru chuupimchaaru. eee pariseelana nundi pleakhg2 anedi kana chalanasheelata yokka mukhyamaina niyantrikagaa pariganinchabadindi.
inca, iteevali samvatsaraalalo, vividha kanaantara sankethaala dwara phosphorylation mariyu itara proteinlatho paraspara charya vanti savaranala dwara pleakhg2 niyantranaku lonavutundani spashtamaindi (paraspara charya/protein savaranapai vibhaganni chudandi). ayithe, vivolo function inca aspashtamgaa undhi.
pleakhg2 kuu sambandhinchina vyaadhi.
2016loe, edwardson mariyu itarulu., dystonia ledhaa prasavaanantara microcephaly unna rogulalo pleckg2 janyuvulo arg204trp mutation kosam homozygosityni gurtinchindi.
paraspara charyalu.
pleakhg2 krindi proteinlatho sankarshana chendutundani telisindi.
βg
β-actin
naalugunnara lim domine1 (efhetchl1)
Â gαs
protein savarana.
plekhg2 eee krindi sankethaala dwara phosphorylation vanti maarpulaku lonavutundani telusu.
sirc
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