hepoxylene

 
hepoxylins (hcx) anevi polyunsaturated fatty ausids (pufa) yokka epoxial alkahal metabolites samiti.ii. avi epoxide mariyu alkahal rendintinee kaligi untaayi (i.ii. hydroxyl) avasheshaalu. kanaalapai, mariyu, mariyu vaati naan-enjaimatikga erpadina isomerlu aamla (pufa), arachidonic aamlam nundi udbhavinchina nonclassic icosanoid. takkuva baga adhyayanam cheyabadina hepoxylins, undavu, mariyu, mariyu vaati naan-enjaimatikga erpadina isomerla rendava samuuham, ivi pufa, icosapentenoic aamlam nundi udbhavinchina nonclassical icosanoids. iteevala, aamlanni mariyu mariyu lanu arachidonic aamlam utpannaalugaa nirvachinchaaru, ivi kanaalapai, mariyu, undavu ledhaa ledhaa kante bhinnamaina jeevakriya maargam dwara utpatti cheyabadataayi mariyu vaati hydroxyl mariyu epoxide avasheshaala sthaanaalalo paina perkonna hepoxylinlaku bhinnamgaa untaayi. chivaraku, docosahexenoic aamlam mariyu linoleic aamlam anae rendu itara pufas yokka hepoxylene lanty utpattulu vivarinchabaddaayi. eee epoxial alkahal metabolites annee kaneesam kontavaraku asthiramgaa untaayi mariyu vaati sambandhita trihydroxy pratyardhulaina trioxylins (trx) kuu takshaname enjaim ledhaa naan-enjaimga untaayi. mukhyamgaa kanaalapai mariyu mariyu, vaegamgaa nundi, truxa3 mariyu mariyu jeevakriya cheyabadutunnayi. hepoxylinlu janthu namuunaalu mariyu/ledhaa samskarinchina ksheerada kanajaalaalu (maanavulato sahaa) mariyu kanaalalo vividha jeeva karyakalapalanu kaligi untaayi. kanaalapai mariyu mariyu yokka trx metabolitelu adhyayanam chesina chaalaa vyavasthalalo takkuva ledhaa etuvanti kaaryaacharananu kaligi undavu, conny konni vyavasthalalo vaati puurvagaami hepoxylinla karyakalapalanu nilupukuntaayi. eee adhyayanala aadhaaramgaa, udaaharanaku, praantiiya rakta pravaham mariyu raktapotunu niyantrinchadaaniki vaapu pratispandanalanu prothsahinchadam mariyu dhamanulanu vistarinchadam dwara maanava sareeradharma shaastram mariyu pathologylo hepoxylinlu mariyu trioxylinlu panicheestaayani pratipaadinchabadindi.
charitra.
kanaalapai mariyu mariyu lanu modata gurtinchaaru, paeru pettabadindi, pettabadindi kenadaaloni langerhans yokka samskarinchina eluka pancreatic iletslo insulin sraavamnu prerepinchadamlo jeeva karyakalapalanu kaligi unnatlu pays-asiac mariyu jm martin dwara choopabadindi. aaa taruvaata koddikaalaanike, pays-asiac gurtinchabadindi, paeru pettabadindi, mariyu insulin secretagog activity undavu mariyu mariyu unnatlu choopinchindi.
naamakaranamu.
kanaalapai, mariyu, mariyu vaati isomerlu chaalaa itara icosanoids (i.ii. 20-carbon kovvu aamlaala aakseekarana dwara tayaaraina sankethaala anuvulu) avi epoxide mariyu hydroxyl avasheshaalu rendintinee kaligi untaayi; avi mukhyamgaa arachidonic aamlam-utpannamaina icosanoids, leukotrians mariyu lipoxins yokka rendu itara taragatula nundi nirmanatmakamga bhinnamgaa untaayi, vaatilo avi samyojita double baandlu kaligi undavu. undavu mariyu mariyu moodu dwandwa bandhaalaku badulugaa naalugu bandhaalanu kaligi undatam dwara kanaalapai mariyu mariyu nundi vaeru cheyabadataayi. 14, 14 mariyu mariyu naan-classical icosanoids paina perkonna hepoxylinla nundi vaeru cheyabaddaayi, avi ververu jeevakriya maargam dwara erpadataayi mariyu vaati epoxide mariyu hydroxyl avasheshaala sthaanaalalo bhinnamgaa untaayi. 22-carbon polyunsaturated fatty assid, docosahexenoic assid mariyu 18-carbon fatty assid, linoleic assid nundi udbhavinchina rendu itara epoxial alkahal kovvu aamlalu, paina perkonna hepoxylinla nundi vaati carbon golusu podavu dwara vaeru cheyabadataayi; vaatini hepoxylene kante hepoxylene lantivi anie pilustaaru. linolic aamlam yokka hepoxylene lanty utpannam linolic aamlam meeda erpadutundi, idhi esterified omega-hydroxylacil-sphingosine (eos) anie piluvabade sanklishta lipidlo oka sphingosinku esterify cheyabadutundi.
naamakarana aspashtatalapai gamanika.
chaalaa adhyayanaalalo hepoxylins mariyu hepoxylene lanty sammelanaala puurti nirmaana gurtimpulu rendu mukhyamaina amsaalalo aspashtamgaa unnaayi. modata, prarambha mariyu aaa taruvaata chaalaa adhyayanaalalo vaati hydroxy avasheshaala yokka "r" verses "s" chirality nirvachinchabadaledu mariyu anduvalla, udaaharanaku, hxb3 nuu 10 "r/s"-hydroxy ledhaa kevalam 10-hydroxyga ivvabadindi. rendavadi, eee munupati adhyayanaalalo epoxide avasheshaala yokka "r", "s" verses "s", "r" chirality kooda nirvachinchabadaledu mariyu udaaharanaku, udaaharanaku 11,12-epoxidega ivvabadindi. konni taruvaati adhyayanalu vaaru veruchesina utpattulaku eee avasheshaala chiraalitiini nirvachinchinappatikii, munupati adhyayanalu eee avasheshaala vadda sarigga oke ledhaa bhinnamaina chiraalitiini kaligi unna utpattulato vyavaharinchaayani tarachugaa spashtamgaa teliyadu.
jeevarasaayana shaastram.
utpatti.
maanava kanaalapai mariyu mariyu rendu-dasala praticharyalo erpadataayi. modata, arachidonic aamlam yokka carbon carbon molecular oxygen (o2) jodinchabadutundi.ii. 5z, 8z, 11z, 14z-icosatetrenoic aamlam) mariyu ekakaalamlo eee arachidonetloni 8 "z" double baand 9 "e" sthaanaaniki kadulutundi, 12 "s"-hydroperoxy-5z, 8z, 10e, 14z-icosatetrenoic aamlam (i.ii. 12 "s"-hydroperoxycosaterone aamlam ledhaa 12 "s"-hpete). rendavadi, 12 "s"-hpete anedi hepoxylene utpattulugaa maarchabadutundi, hxa3 (i.ii. 8 "r/s"-hydroxy-11,12-axido-5 "z", 9 "e", 14 "z"-eicosatrienoic aamlam) mariyu hxb3 (i.ii. 10 "r/s"-hydroxy-11,12-axido-5 "z", 8 "z", 14 "z"-ecosatrinoic aamlam). eee rendu-dasala jeevakriya praticharya krinda vivarinchabadindih
eee praticharyalo rendava dasha, 12 ("luu")-hpete nuu hxa3 mariyu hxb3 gaa marchadam, enjaim yokka antargata aastigaa alox 12 dwara utprerakam cheyabadavachhu. janyu nock avt adhyayanala aadhaaramgaa, epidermal lipoxygenes, alox 3, ledhaa marinta sarigga, daani mouse ortholog alox 3, eluka charmam mariyu vennemuka kanajaalamlo 12 ("luu")-hetch peetnu hcxb hcxb maarchadaaniki baadhyata vahistundi. alox 3 anedi charmam vanti kanajaalaala dwara mariyu mariyu bahusha itara hepoxylinla utpattiki kontha ledhaa mottam dohadam chestundani soochinchabadindi. inca, hydroperoxide kaligina asantrupta kovvu aamlalu vividha rakaala epoxial alkahal isomerlanu roopondinchadaaniki naan-enjaimatikga punarvyavastheekarinchavachhu. kanajaalaalo erpadina 12 ("luu")-heppet, idhi soochinchabadindi, kanaalapai mariyu mariyu nuu roopondinchadaaniki naan-enjaimatikga punarvyavastheekarinchavachhu. punarvyavastheekarinchavachhu mariyu adhyayanalu dwara tayaaru cheyabadina utpattula maadirigaa kakunda, ivi kanaalapai mariyu mariyu matrame yerparustaayi, ayithe, hepoxylinla yokka eee naan-enzymatic utpatti vividha rakaala hepoxylene isomerlanu yerparustundi mariyu kanajaala prosessing yokka kalakhandamga sambhavinchavachhu. chivaraku, cellular peroxidaselu takshaname mariyu vaegamgaa 12 (luu)-hpete nuu daani hydroxyl analog, 12 "s"-hydroxy-5z, 8z, 10e, 14z-icosatetrenoic aamlam (12 "s"-heat; 12-hydroxyecosatetriano aamlam chudandi; eee praticharya hepoxylene-erpade praticharyatho pootiipadutumdi mariyu kanaalalo chaalaa ekkuva peroxidase charyanu vyaktam cheyadaaniki hepoxylins erpadataanni nirodhinchadaaniki baadhyata vahistundi.
eee krindi rendu dasala praticharyalo suuchimchina vidhamgaa arachidonic aamlanni aamlanni mariyu mariyu jeevakriya cheyadaaniki 15-hcxb3): baadhyata vahistundi, idhi modata 15 ("luu")-hydroperoxy-5 "z," 8 "z", 11 "z", 13 "e"-eicosatetraenoic aamlam (15 "s"-hpete) mariyu taruvaata 11 "s/r"-hydroxy-14 "s," 15 "s"-epoxy-5 "z", 8 "z", 12 "eicosatrienoic aamlam (i.ii. 14, 15-hxa3) mariyu 13 "s/r)-hydroxy-14" s, "15" s "-epoxy-5" z ", 8" z ", 11" z "-ecosatrinoic aamlam (i.ii. 14, 14
15-hcxb3): eee praticharyalo rendu dasalanu nirvahinchagala saamarthyaanni kaligi unnatlu kanipistundi, ayithe tadupari adhyayanalu adhyayanalu, naan-enzymatic punarvyavastheekaranalu, mariyu 15 "s"-hpete nuu 15 ("s")-hydroxy-5 "z," 8 "z, 11" z, "13" e "-eicosatetreenoic aamlam (i.ii. 15 "s"-heat; chudandi 15-hydroxycosatetreno aamlam) 14,15-hxa3 mariyu 14,15-hxb3 utpattilo paalgonavacchu, endukante avi hxa3 mariyu mariyu untaayi.
docosahexenoic aamlam yokka hepoxylene lanty metabolites utpatti, 7 "r/s"-hydroxy-10,11-epoxy-4 "z", 7 "e", 13 "z", 16 "z", 19 "z"-docosapentenoic aamlam (i.ii. (i.ii mariyu 10-hydroxy-13,14-epoxy-4 "jedd", 7 "eej", 11 "ii", 16 "jedd", 19 "jedd"-docosapentenoic aamlam (i.ii. (i.ii erpadindi (ledhaa vaati tyhydroxy metabolites erpadatam aadhaaramgaa erpadutundani oohinchabadindi (krinda unna trioxylins chudandi), idhi penial grandhiki docosahexenoic aamlanni jodinchadam ledhaa elukala nundi verucheyabadina hippocompus phalitamgaa erpadindi; eee utpattulanu tayaaru chese maargam (luu) vivarinchabadaledu.
maanavulu mariyu elukala charmamlo linolic aamlam yokka hepoxylene lanty metabolite erpadutundi. eee hepoxylene anedi eos (i.ii. esterified omega-hydroxycile-sphingosine, lipoxygenase#biological function mariyu classification#human lipoxygeneses chudandi) indulo chaalaa podavaina golusu kovvu aamlam kooda untundi. eee maargamlo, పునర్వ్యవస్థీకరించవచ్చుబii esterified linolic aamlanni daani 9 "r"-hydroperoxy utpannaaniki jeevakriya chestundi, aapai alox 3 eee madhyantaraanni daani 13 "r"-hydroxy-9 "r", 10 "r"-epoxy utpattiki jeevakriya chestundi. charmam uparitalam yokka carnified lipid envalap kuu chaalaa podavaina golusu kovvu aamlaalanu andinchadaaniki maargam panichestundi.
marinta jeevakriya.
kanaalapai chaalaa asthiramgaa untundi mariyu mariyu mitamgaa asthiramgaa untundi, udaaharanaku, telikapati aamla paddhatulanu upayoginche isolation vidhaanaala samayamlo, vaati trai-hydroxy utpattulaku vaegamgaa kullipotundi; avi kooda adhe trai-hydroxy utpattulaku kanaalalo vaegamgaa enjaimalise cheyabadataayi, veetini trioxylins (trucks) ledhaa trihydroxychoincstroicstorate aamlalu (theta) anie pilustaaru; kanaalapai nuu 8,11,12-trihydroxy-5 "z", 9 "e", 14 "z"-ecosatrinoic aamlam (trioxylene a3 ledhaa ledhaa gaa maarchabadutundi, ayithe ayithe nuu 10,11,12-trihydroxy-5 ", 8", "14", genos-trioxylic aamlam (trioxylic aamlam) gaa maarchabadutundi. moodava trihydroxy aamlam, 8,9,12-trihydroxy-5 "z", 10 "e", 14 "z" icosatrinoic aamlam (trioxylene c3 ledhaa trxc3), kundelu mariyu eluka yokka iorta kanajaalamlo arachidonic aamlamtho podiginatlu kanugonabadindi. eluka kaaleyamlo karige epoxide hydroless dwara kanaalapai nundi nundi mariyu mariyu nundi trucks yokka jeevakriya saadhinchabadutundi; idhi maanavulato sahaa vividha ksheerada jaatula vividha kanajaalaalo vistrutamgaa pampinhee cheyabadinanduna, karige epoxide hydroless veetini mariyu bahusha itara hepoxylene sammelanaalanu jeevakriya cheyadaaniki baadhyata vahinche pradhana enjaim kaavacchu. ayithe, microsomal epoxide hydroless ledhaa epoxide hydroless 2 vanti itara idhe vidhamaina epoxide hydroless hepoxylene hydroless kaaryakalaapaalaku rujuvu kaavacchu. hepoxylene samslaeshanha yokka trihydroxy utpattulu saadhaaranamgaa kriyaarahitamgaa pariganinchabadataayi mariyu anduvalla hepoxylinla charyalanu parimitam cheyadaaniki seh maargam panichestundani pariganinchabadutundi, konni adhyayanalu mundugaa-sanklishtamaina eluka dhamanulanu sadalinchadamlo kanaalapai kante kante, metabolite mariyu mariyu marinta saktivantamainavani kanugonnayi mariyu mariyu kundelu mundu-sanklishtamaina bruhaddhamani yokka saapekshamgaa saktivantamaina sadalimpu.
glutathione badilee dwara utprerakam cheyabadina maikhel adanamgaa daani glutathione conjugate, hxa3-c, hxa3-c hxa3 maarchabadindi.ii., maarchabadindi.ii, sell-free systemlo ledhaa eluka medadu hippocompus kanajaalam yokka homogenatelalo; homogenatelalo; eluka hippocompal hippocompal neuronlalo membrane hyperpolarisation yokka saktivantamaina uddeepanagaa niroopinchabadindi. hepoxylene a3-c yokka eee nirmaanam leukotrione c4 yokka glutathione yokka samyogam dwara leukotrione a4 yokka nirmaanaaniki saruupyamgaa kanipistundi. 14,15-hxa3 mariyu 14,15-hxb3 yokka glutathione samyogaalu kooda maanava hodgkin vyaadhi reed-sternberg sell line, l1236 nuu kanugonnayi.
maanava psoriasis gayalalo phospholipid yokka "sn"-2 sthaanaaniki mariyu maanava psoriatic charmam assilate hetchxbidableu mariyu mariyu namuunaalanu vitrolo eee phospholipidlalo essterify cheyabadinatlu mariyu mariyu mariyu kanugonabaddayi.
saareeraka prabhavalu.
hepoxylinlapy daadaapu anni jeeva adhyayanalu jantuvulalo ledhaa jantuvulu mariyu maanava kanajaalaalapai inn vitrolo nirvahinchabaddaayi, ayithe, eee adhyayanalu jaatula-nirdishta vibhina phalitaalanu istayi, ivi manavulaku vaati sambandhitatanu klishtataram chestaayi. maanava sareeradharma shaastram, pathology, clinical medicine mariyu chikitsalaku eee adhyayanala upayogakaramaina anuvaadaaniki marinta adhyayanam avasaram.
vaapu.
udaaharanaku, maanava neutrophil chemotoxisnu prerepinchadam mariyu charma kesanaalikala paaragamyatanu penchadam vanti vaatilo kanaalapai mariyu mariyu proo-inflammatory charyalanu kaligi untaayi. maanavulalo jarigina adhyayanalu psoriatic gayalalo saadhaarana epidermis kante mariyu mottam 16 retlu ekkuvagaa undani kanugonnayi. idhi psoriatic pramaanaalalo ~ 10 micromolar vadda untundi, idhi jeevasambandhamaina prabhavalanu chuupagala ekagrata; eee kanajaalaalo mariyu kanugonabadaledu, ayithe daani metabolite, metabolite, psoriatic pramaanaalalo saapekshamgaa adhika sthaayilalo undatam dwara balamgaa soochinchabadindi, conny saadhaarana epidermal kanajaalam kaadu. eee phalitaalu Hxa3 mariyu Hxb3 yokka shotha nirodhaka prabhavalu psoriasis mariyu bahusha itara charma paristhithulatho paatu vachhe shotha pratispandanaku dohadam cheyavachani suuchistunnaayi. Hxa3 anedi pregulu mariyu elukala oopiritittulaloni vividha bacteriaku neutrophil aadhaarita taapajanaka pratispandananu prothsahinchadamlo kooda suuchistumdi.idhi eee hepoxylene itara kanajaalaalo, mukhyamgaa shleshmam uparitalam unnavaarilo, charmamtho paatu maanavula taapajanaka pratispandananu kooda prothsahinchadaaniki veelu kalpistundi. adanamgaa, kanaalapai mariyu mariyu, pbt-3 yokka synthetic analog, neutrophil extracellular traplanu utpatti cheyadaaniki maanava neutrophillanu prerepistaayi, antey.ii. dna-adhikamgaa unde extracellular fibrill maatrikalu kanajaalaanni taggistuu extracellular paathogenlanu champagalavu; anduvalla eee hepoxylinlu pathogenla pratyaksha hatyaku baadhyata vahinchadam dwara sahaja roganirodhaka saktiki dohadam cheyavachu.
prasarana.
12 "s"-heat mariyu 12 "r"-heat (12-hete#blood ottidi chudandi), hxa3, trxa3, mariyu trxc3 thoo paatu, conny hxb3 ledhaa trxb3 vantivi kooda thromboxane a2 dwara mundugaa kudinchabadina mouse macentary dhamanulanu sadalinchavu) (txa2). yaantrikamgaa, eee gvakriyalu vascular endotheliumlo erpadataayi, underline cheyabadina mruduvaina kandaraalaku kadulutaayi mariyu grahaka virodhigaa panicheyadam dwara txa2 valla kalige mruduvaina kandaraala sankochaanni tippikodataayi, antey.ii. avi txa2 yokka bandhaanni daani thromboxane grahakam, α isopharmku poteegaa nirodhistaayi. dheeniki viruddhamgaa, 15-lipoxygenes-utpannamaina epoxial alkahal mariyu arachidonic aamlam yokka trihydroxy metabolites.15-hydroxy-11,12-epoxycosatrinoic aamlam, 13-hydroxy-14,15-epoxy-icosatrinoic aamlam aamlam isomer), mariyu 11,12,15-trihydroxyicosatricotrine aamlam kundelu bruhaddhamanini endothelium-utpanna hyperpolarising phyaaktar (edhetchf) mechanism dwara vistaristundi.ii. avi naalaala endotheliumlo erpadataayi, antarleena mruduvaina kandaraalaku kadulutaayi mariyu hyperpolarisation (jeevasaastram)-prerita sadalimpu yokka pratispandananu prerepistaayi, tadwara vaati apamine-sensitive small conductains (ess. keey) calcium-activated potassium <ii. dii. 1> chaanellanu terustaayi. udaharinchina gvakriyalu eee rendu vidhanalalo okati ledhaa marokadaanni ververu vascular padakalalo mariyu ververu janthu jaatulalo praantiiya rakta pravaham mariyu raktapotunu niyantrinchadamlo dohadam cheyadaaniki upayoginchavacchu. maanava vasculaturelo eee metabolitela paatra adhyayanam cheyabadanappatiki, 12 "s"-heat, 12 "r"-heat, hxa3, trxa3, mariyu trxc3 maanava thromboxane graahakaaniki txa2 yokka bandhaanni nirodhistaayi.
noppi avagahana.
charma vaapuku elukala hyperalgesia mariyu sparsha allodynia (saadhaaranamgaa noppi laeni uddeepana valla kalige noppi) pratispandanaku kanaalapai mariyu mariyu kaaranamavutaayi. eee namoonaalo, hepoxylinlu vennupaamulo vidudala cheyabadataayi mariyu noppi yokka avagahananu penchadaaniki neerugaa chestaayi mariyu mariyu grahakalanu sakriyam chestaayi. chestaayi (transient receptor potential cashion chaanal sabfamili vii member 1 1, capsicin receptor ledhaa vanilloid receptor anie kooda pilustaaru) mariyu mariyu (transient receptor potential cashion chaanal, member eah1) kanaalapai plasma membrane ayan chaanallu; eee chaanellu maanavulato sahaa vistruta shreni janthu jaatulalo exogenous mariyu endogenous bhouthika mariyu rasayana uddeepanala valla kalige noppi yokka avagaahanalo paalgontaayani telusu.
aakseekarana ottidi.
aakseekarana ottidiki guraina samskarinchabadina eluka eluka pancreatic ilet kanaalu kanaalu sravistaayi; mariyu (mariyu (mariyu eee ottidini tagginchadaaniki panichese peroxidase enjaimlanu niyantristundi; eee eee accidasela prerana anedi vividha kanaala dwara vaati shakti mariyu kaaryaacharananu rakshinchadaaniki upayoginche saadhaarana parihara rakshana pratispandananu kaligi untundani pratipaadinchabadindi.
insulin sraavam.
elukala pancreatic ilet kanaalapai kanaalapai mariyu mariyu yokka insulin-sravinche charyalalo glucose yokka insulin-sravinche charyanu penche ledhaa saktivantam chese saamarthyam untundi, dheeniki chaalaa ekkuva saandratalu avasaram (udhaa.zii. hepoxylins yokka 2 micromolar), mariyu chekkuchedarakunda unna jantuvulaku ledhaa manavulaku vistarinchabadaledu.
hepoxylinlu kooda medadulo utpatti avtayi.

