poolika

retroelement silencing phyaaktar 1 anedi maanavulalo resf 1 janyuvu dwara encode cheyabadina protein. poolika vistrutamgaa shosharasa kanupulu, andaasayaalu, appendix mariyu pleehamlo vyakteekarinchabadutundi. poolika oka chinna hystocompatability antigen, alaage kaniti anichivese saamarthyaalu anae lakshanaalanu chooputundi. shosharasa kanupulu mariyu pleehamlo adhika vyakteekarana roganirodhaka vyavasthalo paniteerunu suuchistumdi.
janyuvu.
poolika anedi chromosome chromosome kanipinche protein coding janyuvu mariyu 12p11.21 kuu mapp chestundi. eee janyuvuku pratyaamnaaya paerlaloo gonad expressed transcript (gett), (gett) mariyu mariyu unnaayi. unnaayi 7 exanlu unnaayi, veetilo 3 prarambha kodanku mundu sambhavistaayi.
kanajaala vyakteekarana.
saadhaaranam.
saadhaarana maanava kanajaala vyakteekarana profiling yokka adhyayanam poolika thymus, pleehamu, emuka majja mariyu kaaleyamlo ekkuvagaa vyakteekarinchabadindani choopistundi. idhi roganirodhaka vyavasthaku sambandhinchina saadhaarana avayavalaku sambandhinchinadi kabatti idhi aasaktikaramgaa untundi.
national center pharr biotechnology information dwara kanugonabadina janyu kanajaala vyakteekarana namuunaalu unigene est profile shosharasa kanupulu, garbhasayam, noru, thyroid, swarapetika mariyu raktamlo kooda poolika yokka adhika vyakteekarana undani choopinchindi.
cancer.
aarogya sthithulalo poolika vyakteekarana yokka moolyaankanam enn. sii. bii. ii. unigene yokka est profilenu upayoginchi nirvahinchabadindi. garbhasaya kanitulalo poolika ekkuvagaa vyakteekarinchabadinappatiki, idhi garbhaasayamlo kooda ekkuvagaa vyakteekarinchabadutundi, idhi janyuvu garbhasaya cancertho daggari sambandham kaligi undakapovachani suuchistumdi. ayithe, poolika adrenal kanitulaku sambandhinchinadi kaavacchu, endukante saadhaarana moothrapindaala kanajaalamlo eee janyuvu yokka takkuva vyakteekarana undhi.
transcript.
transcription phyaaktar binding saitlu.
poolika yokka prothsaahakamlo transcription phyaaktar binding saitlalo pradhanamgaa emuka majja kanaalu, antibody utpatti chese kanaalu mariyu rakta kanaalatoe sambandham unna transcription karakalu unnaayi. idhi panichese roganirodhaka vyavasthatho poolika anubandhaaniki maddatu istundi.
protein.
poolika podavu 1747 amaino aamlalu mariyu teliyani function yokka oka domine, duf 4617 kaligi undhi. poolika yokka paramaanu baruvu 194.9 kedal. besal isoelectric point 8.95. oka sthaanikeekarana anchanaa poolika bahusha anhu protein anie suuchistumdi.
protein nirmaanam.
poolika yokka dviteeya nirmaanamloo pradhanamgaa yaadruchchika kaayil nirmaanaalu (sumaruga 59.2%), konni alfa helix (avasheshaalalo 24 saatam) mariyu takkuva podiginchina tantuvulu (avasheshaalalo 15.8%) untaayi.
paina chuupina swiss modal pani sthalaanni upayoginchi anchanaa vesina 3-dii nirmaanam srushtinchabadindi.
protein paraspara charyalu.
poolika nanog, endukante, pratispandanagaa mariyu anie latho sankarshana chendutundi. eee sankarshanhalu poolika anedi anhu protein anie, idhi kaniti-anachivese proteins mariyu roganirodhaka vyavastha proteinlatho sambandham kaligi undavacchani suuchistunnaayi.
schizophrenia pramaada janyuvu (disk 1) nuu protein-protein paraspara charyala netvarkku sambandhinchina schizophrenia adhyayanamlo exoc 1 paalgonnadi. eee adhyayanam poolika mariyu pratispandanagaa madhya protein paraspara charyaku saakshyamgaa rendu-hybrid vislaeshanhanu upayoginchindi. microbial infectionlaku pratispandanagaa pratispandanagaa panichestundi, idhi viral rna samslaeshanha mariyu protein anuvaadaanni taggistundi.
nanog anedi kana chakramtho sambandham unna proteinlatho naanognu anusandhaaninche anubandham sangraha-ms aadhaaramgaa పోలికతoouu sankarshana chendutundani anchanaa veyabadindi. eee adhyayanam nirdishta protein paraspara charyalanu kanugonadaaniki adhika khachitatvam maas spectrometrytho kalipi affinity suddeekarananu upayoginchindi. pinda muula kanaalalo nanog kooda oka mukhyamaina transcription karakamga kanugonabadindi, pratyaekamgaa kana vidhini prabhaavitam cheyadaaniki janyu vyakteekaranalo paalgontundi.
endukante anedi kana chakram mariyu apoptosisnu prabhaavitam cheyadaaniki itarulatoe sankarshana chendhe janyuvu, mariyu garbhasayam mariyu shosharasa grandhi vanti పోలికకii saadhaarana kanajaalaalo untundi. faze display libraryni upayoginchadam dwara endukante పోలికతoouu sankarshana chendutundani kanugonabadindi. eee paraspara charya poolika anedi nuclear protein anie suuchistumdi, endukante endukante mariyu daani splies vaeriyantlu nucleoplasmic pampinhee kosam nuclear localization sankethaalanu kaligi untaayi.
nanog poolika thoo elaa sankarshana chendutundo kanugonnatle, affinity capture-ms aselo aadhaaramgaa poolika thoo sankarshana chendadaaniki anie kanugonabadindi. epidermal abhivruddhilo anie vyakteekaranapai chesina adhyayanamlo anie abhivruddhiki upayogakaramaina marker anie, anie vyakteekarana kolpovadam praanaantaka samalakshanhaalato sambandham kaligi undani choopinchindi.
parinaama sambandha sambandhaala.
orthologs.
పోలికకii atyanta daggaragaa unde orthologlu primatelu, ayithe, rakshita shrenulanu timingalaalu, elugubantlu, pamulu, pakshulu, taabellu mariyu kappalalo chudavachu. poolika yokka orthologlu chaalaa kaalam kritam 35.3 kotla samvatsaraala kritam ("genopus lavis") vaeru cheyabaddaayi, ayithe sameepa parinaamaatmaka ortholog "papeo anubis", idhi sumaru 28.1 kotla samvatsaraala kritam vaeru cheyabadindi.
phylogenetic chettu.
poolika yokka verupadani phylogenetic chettu 20 orthologlu mariyu maanava poolika janyuvutho srushtinchabadindi.
molecular phylogeny.
poolika yokka paramaanu parinaamam krinda chuupina graph, cytochrome sii, nemmadigaa abhivruddhi chendutunna protein mariyu fibrinogen alfa, cytochrome sii kante vaegamgaa abhivruddhi chendina cytochrome sii rendintitho poliste idhi saapekshamgaa vaegamgaa abhivruddhi chendindani choopistundi. eee poolika poolika chaalaa twaragaa vibhedistundani choopistundi, idhi vyadhikaarakaanni pravesapettadam vanti daani paryaavaranaaniki pratispandanagaa twaragaa maare janyuvu kaavacchu anie suuchistumdi. 

