
glucose-galactose malabsurption

glucose-galactose malabsurption anedi oka arudaina paristhiti, dheenilo pregulalo unde kanaalu chakkera glucose mariyu galactoselanu teesukolevu, idhi eee anuvulu mariyu vaati nundi tayaaraina pedda anuvula saraina jeernakriyanu nirodhistundi.
glucose mariyu galactoselanu saadhaarana chakkeralu ledhaa monosaccharides antaaru. sukroj mariyu lactoselanu disaccharides anie pilustaaru, endukante avi rendu saadhaarana chakkeralatho tayaaravutaayi mariyu jeernakriya samayamlo eee saadhaarana chakkeralaga vidipotaayi. sukroj glucozga mariyu fructose anie piluvabade maroka saadhaarana chakkeraga vibhajinchabadutundi mariyu lactose glucose mariyu galactosega vibhajinchabadutundi. phalitamgaa, carbohydratelatho tayaaraina lactose, sukroj mariyu itara sammelanaalanu glucose-galactose malabsurption unna vyaktulu jeernam cheyaleru.
janyusaastram.
slc5eah1" janyuvu sglt1 anie piluvabade sodiyam/glucose cottransporter proteinnu utpatti cheyadaaniki suuchanalanu andistundi. eee protein pradhanamgaa pregulalo mariyu kontavaraku moothrapindaalalo kanipistundi, ikkada idhi glucose mariyu nirmanatmakamga saaruupya galactosenu kana porallo ravana cheyadamlo paalgontundi. pregu godalaku varusalo unde kanaalu ayina pegu epithelial kanaala paniteerulo sodiyam/glucose cottransporter protein mukhyamainadi. eee kanaalu microville anie piluvabade velimudrala vanti anchanaalanu kaligi untaayi, ivi pregu gundaa velutunnappudu aaharam nundi poeshakaalanu grahistaayi. vaati roopaanni batti, eee microville samuuhaalanu samishtiga brush sarihaddu anie pilustaaru. sodiyam/glucose cottransporter protein pora antataa sodiyam pravanata kaaranamgaa instessinal kanaalalo glucose teesukune prakriyaloo paalgontundi. idhi dviteeya kriyaaseela ravana endukante sodiyam/calcium exchanger paniteeru kosam utpatti cheyabadina sodiyam pravanata sodiyam/potassium pump dwara srushtinchabadutundi, dheeniki eah. tii. pii avasaram. eee prakriyaloo chakkeralatho paatu sodiyam mariyu neeru brush sarihaddu meedugaa ravana cheyabadataayi.
sodiyam/glucose cottransporter protein eee panini cheyakunda nirodhinche utparivartanalu pregulalo glucose mariyu galactose erpadataaniki daariteestaayi. kriyaaseela ravana yokka eee vaiphalyam glucose mariyu galactose grahinchakundaa mariyu sariiraaniki poeshanhanu andinchakundaa nirodhistundi. adanamgaa, saadhaaranamgaa chakkeratho brush sarihaddu gundaa ravana cheyabade neeru badulugaa malam dwara bahishkarinchadaaniki pregula maargamlo untundi, phalitamgaa shareera kanajaalaalu nirjaleekaranaaniki mariyu teevramaina virechanaalaku daariteestundi.
eee paristhiti autosomal recessive namoonaalo vaarasatvamgaa vastundi, antey prati kanamlooni janyuvu yokka rendu kaapeelu maarchabadataayi. chaalaa tarachugaa, autosomal recessive desorder unna vyakti yokka tallidandrulu prati okkaroo marchabadina janyuvu yokka oka kaapeeni kaligi untaaru, conny rugmata yokka sankethaalu mariyu lakshanaalanu choopincharu. konni sandarbhaallo, oka maarpu chendina janyuvu unna vyaktulu prayogasaala pareekshalalo kolichinatlugaa glucose shoshana saamarthyaanni tagginchaaru, conny idhi saadhaaranamgaa gananeeyamaina aarogya prabhavalanu chuupaleedani telindi.
rooga nirdhaarana.
glucose-galactose malabsurption saadhaaranamgaa sisuvu jeevitamlo modati konni varalalo spashtamgaa kanipistundi. prabhaavita sisuvulu teevramaina atisaaraanni anubhavistaaru, phalitamgaa praanaantakamaina nirjaleekaranam, raktam mariyu kanajaalaala aamlata (acidosis) perugutundi mariyu talli paalu ledhaa saadhaarana sisuvu suutraalanu tinipinchinappudu baruvu taggutundi. ayithe, vaaru glucose ledhaa galactose laeni fructose aadhaarita suutraalanu jeernam cheyagalugutaru. kontamandi prabhaavita pillalu peddayyaaka glucose mariyu galactoselanu baga thattukogaluguthaaru.
moothramlo chinna mottamlo glucose (telikapati glucosuria) eee rugmatalo appudappudu sambhavinchavachhu. prabhaavita vyaktulu moothrapindaallo raallu ledhaa moothrapindaala lopala calcium yokka marinta vistrutamaina nikshaepaalanu kooda abhivruddhi cheyavachu.
glucose-galactose malabsurption anedi arudaina rugmata; prapanchavyaaptamgaa konni vandala kesulu matrame gurtinchabaddaayi. ayithe, janabhalo 10 saatam mandhi sambandhita aarogya samasyalu lekunda glucose shoshana saamarthyam kontavaraku taggavacchu. eee paristhiti glucose-galactose malabsurption yokka telikapati vaividhyam kaavacchu.
chikitsa.
chikitsalo pradhanamgaa fructose aadhaarita suutraalanu mariyu glucose mariyu galactose (mariyu disaccharides sukroj mariyu lactose) utpattulu mariyu padaarthaalalo lopam unna kramam tappakunda aaharam teesukovadam untaayi.