
immunotaxin

immunotaxin anedi oka taxinto mudipadi unna lakshya bhaganni kaligi unna oka krutrima protein. protein aaa kanamtho bandhinchinappudu, adhi endocytosis dwara teesukobadutundi, mariyu vishamu kanaanni champutundi. veetini konni rakaala cancer mariyu konni viral infectionla chikitsa kosam upayogistaaru.
design.
eee chimerick proteins saadhaaranamgaa oka taxin yokka bhaagaaniki jatacheyabadina savarinchina antibody ledhaa antibody sakalamtho tayaaru cheyabadataayi. lakshya bhaagam oka nirdishta kana rakanni lakshyamgaa chesukune antibody yokka fab bhaagamtho koodi untundi. taxin anedi saadhaaranamgaa abb taxin, idhi bacteria ledhaa mokkala protein nundi pondina cytotoxic protein, dheeni nundi sahaja binding domine tolaginchabadindi, tadwara eff. vii. taxinnu lakshya kanamlooni antigenku nirdesistundi.
konnisaarlu taxin mariyu perugudala karakanni kaligi unna recombinant fusion proteinlanu recombinant immunotoxins anie kooda pilustaaru, ayinappatikee avi antibody sakalaanni kaligi undavu. eee taruvaati rakamaina proteinku marinta nirdishta paeru recombinant fusion taxin.
utpatti.
rasayana anusandhanakaanni upayoginchi vishaniki pratirakshakaanni jodinchadam dwara avi modata utpatti cheyabaddaayi. avi ippudu recombinant dna paddhatulanu upayoginchi tayaaru cheyabadataayi, ivi "ii" vanti bacterialo utpatti cheyabadataayi. collis "nuu recombinant immunotoxins antaaru.
function.
antibody (ledhaa itara lakshya bhagalu) lakshya kanampai oka antigentho bandhistundi mariyu aaa vishamu appudu kanamloki pravesinchi champutundi.
clinical application.
vakreebhavana ventrukala kana leukemia unna rogulaku chikitsa cheyadamlo uttama clinical vijayam saadhinchabadindi. eee rogulaku eee luchemic kanaalapai sidi22 kana uparitala grahakanni lakshyamgaa chesukune recombinant immunotoxintho chikitsa andinchaaru. rendu aniyantrita clinical adhyayanaalalo, paalgonevaarilo sagam mandhi bl 22 chikitsa tarvaata puurti pratispandananu saadhinchaaru. eee chikitsanu konchem savarinchina hechae22 dwara bharti chesaaru.
charma tii sell lymphoma unna tommidi mandhi rogula upa samuuhamloo resimmune yokka iteevali modati dasha adhyayanam 89 saatam pratispandana retunu kanugondi. eee upa samuuham 50 kante takkuva emswatt skorlatho dasha aibi-iib. puurti pratispandana raetu 50 saatam (veetilo rendu 72 nelala vyavadhilo unnaayi mariyu nivaaranalanu suuchistaayi).

