
carfilzomib

kyprolis brand paerutoe vikrayinche carfilzomib, cancer nirodhaka aushadham, idhi empika chesina proteazome inhibitorga panichestundi. rasaayanikamgaa, idhi tetrapeptide epoxicatone mariyu epoxomycin yokka analog. dheenini onix pharmaceuticals abhivruddhi chesindi.
us phud und drugg administration (fda) dheenini juulai 2012loe aamodinchindi.
vaidya upayogaalu.
bortezomib chikitsa mariyu immunomodulatory therapy (lenalydomide vantivi) thoo sahaa kaneesam rendu mundastu chikitsalanu pondina mariyu chivari chikitsa puurtayina 60 rojulalopu ledhaa lopala vyaadhi purogatini pradarsinchina bahula myloma unna vyaktulalo upayogam kosam juulai 2012loe fda carfilzomibnu aamodinchindi.
yantraangam.
carfilzomib samayojaneeyamgaa 20la proteasome yokka chemotrypsin lanty charyatho bandhistundi mariyu nirodhistundi, idhi avaanchita cellular proteinlanu ksheeninche enjaim. carfilzomib protesomal kaani lakshyaalato kaneesa paraspara charyalanu pradarsistundi, tadwara bortezomib meeda bhadrata profilenu meruguparustundi. proteasome-madhyavartitva proteolysis nirodham phalitamgaa polyubiquitated proteins erpadataayi, ivi kana chakram aagipovadaaniki, apoptosis mariyu kaniti perugudalanu nirodhinchadaaniki kaaranam kaavacchu.
charitra.
carfilzomib anedi epoxomycin nundi teesukobadindi, idhi yael vishwavidhyaalayamloni craigg sibbandi prayogasaala dwara proteazomnu nirodhinchadaaniki chuupabadina sahaja utpatti. sibbandi prayogasaala taruvaata yuu 101 anae epoxomycin yokka marinta nirdishta utpannaanni kanugonnadi, idhi proteolics, inkku licenses pondindi. proteolics saastravettalu maanavulalo aushadhamgaa sambhaavya upayogam unna kotta, pratyaekamaina sammelanaanni kanugonnaru, dheenini carfilzomib anie pilustaaru. proteolics carfilzomibnu bahula dasha I mariyu II clinical trials kuu abhivruddhi chesindi, vegavantamaina aamodam pondadaaniki roopondinchina keelakamaina dasha 2 clinical trialtho sahaa. 2009loe proteolicsnu konugolu chesina onix pharmaceuticals kinda carfilzomib kosam clinical trials konasagutunnayi.
janavari 2011loe, fda carfilzomib faast-track hodaanu manjuru chesindi, carfilzomib kosam daani kotta aushadha darakhaastunu rolling samarpananu praarambhinchadaaniki oniksnu anumatinchindi. december 2011loe, fda, onix praamaanika sameeksha hodaanu manjuru chesindi, idhi oka open-label, single-arm faze iib trial ayina, 303-eah1 adhyayanam aadhaaramgaa daani kotta aushadha darakhaastu samarpana kosam. bortezomib mariyu thalidomide ledhaa lenalidomydto sahaa kaneesam rendu mundastu chikitsalanu pondina punaraavruta mariyu vakreebhavana bahula myloma unna 266 mandhi teevramgaa chikitsa pondina rogulanu vichaarana anchanaa vesindi.
pratispandana raetu aadhaaramgaa prarambha aamodam labhinchindi. mottam manugada prayojanaanni pradarsinche dayta prayatna vichaaranalo pradarsinchabadindi mariyu fdhe aamodinchabadindi.
clinical trials & side effects.
puurti chesaaru.
relapsed mariyu refractory multiple myloma unna rogulalo carfilzomib yokka single-arm, faze II trial (303-eah1), oke agent carfilzomib 266 mandhi rogulalo 36 saatam clinical benefit retunu pradarsinchindani mariyu mottam pratispandana raetu 22.9% mariyu pratispandana yokka madhyastha vyavadhi 7.8 nelalu anie choopinchindi. carfilzomib yokka fda aamodam, 303-eah1 vichaarana phalitaalapai aadharapadi undhi.
rendava dasha vichaarana (004) loe, gatamlo bortezomib andukoni relapsed mariyu/ledhaa refractory multiple myloma unna rogulalo carfilzomib mottam 53 saatam pratispandana retunu kaligi undhi. eee adhyayanamlo bortezomib-treat cheyabadina samuuham kooda undhi. phalitaalu vidigaa nivedinchabaddaayi. eee adhyayanam deerghakaalika carfilzomib chikitsa sahinchadaginadani kooda kanugondi, sumaru 22 saatam mandhi rogulu oka samvatsaraaniki minchi chikitsanu konasaaginchaaru. 004 trial anedi takkuva mundastu chikitsa pondina (1-3 mundastu niyamaalu) rogulalo bortezomib chikitsaku sambandhinchi carfilzomib chikitsa yokka prabhavanni parisoedhinchadaaniki modata roopondinchina oka chinna adhyayanam.
bahula myloma mariyu vividha sthaayila moothrapindaala balaheenata unna rogulalo, daadaapu 50 saatam mandhi rogulu bortezomib mariyu lenalydomide rendintikee vakreebhavanam kaligi unna rogulalo, carfilzomib yokka bhadrata, pharmacokinetics, pharmacodynamics mariyu saamarthyaanni anchanaa vesina rendava dasha trial (05), pharmacokinetics mariyu bhadrata baseline moothrapindaala balaheenata sthaayi dwara prabhaavitam kaaledani niroopinchindi. carfilzomib sahinchadaginadi mariyu samarthatanu pradarsinchindi.
maroka dasha II trial (06) loe, relapsed mariyu/ledhaa refractory multiple myloma unna rogulalo, lenalydomide mariyu dexamethasone kalayikatho carfilzomib mottam pratispandana retunu 69 saatam pradarsinchindi.<riff paeru = "neeswizki aarr mariyu itarulu.relopsed ledhaa progressive multiple myloma (aarr/aarr mimi) unna rogulaku lenalydomide mariyu takkuva motaadu dexamethasone (crd) thoo kalipi carfilzomib (cfged) yokka dasha 1bii/2 adhyayanam (px-171-006) nundi tudi phalitaalu >
bahula myloma mariyu ghana kanitula kosam rendava dasha pareeksha (307) aasaajanaka phalitaalanu choopinchindi.
carfilzomib yokka rendava dasha pareekshalalo, atyanta saadhaarana grade 3 ledhaa anthakante ekkuva chikitsa-udbhavinche pratikuula sanghatanalu thrombocytopenia, raktaheenata, lymphopenia, neutropenia, pneumonia, alasata mariyu hyponetramiatho hematologic vishapuuritam.
modati/rendava dasalo, carfilzomib, lenalydomide mariyu takkuva motaadu dexamethasone kalayika chaalaa churukuga mariyu baga thattukogaligindi, kottagaa nirdhaarana cheyabadina bahula myloma rogulalo puurti motaadulanu ekkuva kaalam upayoginchadaaniki veelu kalpinchindi, motaadu savarana parimita avasaramtho. pratispandanalu vaegamgaa mariyu kalakramena merugupaddayi, 100% chaalaa manchi pakshika pratispandanaku cherukunnayi.
antekakunda, atisaaram mariyu vikaram vanti jeernasayaantara aatamkaalu anevi saadhaaranamgaa proteasome inhibitorsto nivedinchabadina hematologic kaani dushprabhaavaala samuuham. adanamgaa, myocardiumloni proteazomelapy prabhaavaala kaaranamgaa carfilzomib chikitsa phalitamgaa hridaya sambandha vishapuuritam kaavacchu. anduvalla, carfilzomibto chikitsanu praarambhinchadaaniki mundu roogi moolyaankanam mariyu pramaada anchanaa keelakam.
vichaarananu korukovadam.
aspire trial anie piluvabade moodava dasha nirdhaarana clinical trial, carfilzomib, lenalydomide mariyu dexamethasone (krd) verses lenalydomide mariyu dexamethasone (rd) thoo polchi, punaraavruta bahula myloma unna rogulalo merugaina purogati-rahita manugada mariyu mottam manugadanu kanugondi. pratikuula prabhaavaala kaaranamgaa chikitsa nilipiveyadam anedi krd chetilo takkuva tarachugaa sambhavinchindi, mariyu sanghatanalalo thrombocytopenia, adhika raktapotu mariyu gunde vaiphalyam unnaayi. 
samajam mariyu samskruti.
aardhikasaastram.
carfilzomib 28 rojula chakraniki sumaruga kharchu avutundi.

