bhaagamgaa

bhaagamgaa ledhaa bhaagamgaa cytotoxic granuel-sambandhita rna binding protein anedi 3 'uter marnah binding protein, idhi 5' top mrnla yokka 5 'top kramaanni bandhinchagaladu. idhi kramabaddheekarinchina kana maranam (apoptosis) thoo mudipadi untundi mariyu apoptosis-prothsahinche protein ayina phaas grahakanni encoding chese janyuvu yokka pratyaamnaaya vibajananu niyantristundi. ottidi paristhitulalo, bhaagamgaa ottidi kanikalu anie piluvabade cellular rna-protein sammelanaalaku sthaanikeekaristundi. idhi bhaagamgaa janyuvu dwara encode cheyabadindi.
cheyabadindi janyuvulo utparivartanalu amyotrophic lateral sclerosis, frantotemporal dementia mariyu velander distal mayopathitho mudipadi unnaayi. algimers vyaadhiloo vishapuurita oligomeric tou abhivruddhilo kooda idhi keelaka paatra poeshistumdi.
function.
eee protein transcription mariyu rna translation niyantrinche rna-binding protein kutumbaaniki chendinadi. idhi modata cytotoxic lymphocyte (ctl) lakshya kanaalalo gurtinchabadindi. spliesing mariyu transcription niyantrinchadaaniki bhaagamgaa nucleuselo panichestundi. rna spliesingnu niyantrinchadaaniki splisomnu niyaminchadaaniki bhaagamgaa sahaayapadutundi, mariyu idhi cytokine tumour necrosis phyaaktar alfa vanti bahula janyuvula transcription nirodhistundi. ottidiki pratispandanagaa, bhaagamgaa kendrakam nundi cytoplasmku maarutundi, ikkada idhi ottidi kanika anie piluvabade oka rakamaina rna kanikanu kendrakam chestundi mariyu anuvaada ottidi pratispandanalo paalgontundi. anuvaada ottidi pratispandanalo bhaagamgaa, bhaagamgaa itara rna binding proteinla sahakaaramtho panichestundi, ribozome nundi rna transcriptsnu vaeru cheyadaaniki, idhi kanaanni daani protein samslaeshanha/rna anuvaada yantraamgaanni nirdishta ottidini parishkarinche proteinlanu utpatti cheyadampai drushti pettadaniki anumatistundi. eee protein apoptosis preranalo paalgontunnatlu soochinchabadindi, endukante idhi paalii (eah) homopolymerlanu praadhaanyamutho gurtistundi mariyu ctl lakshyaalalo dna vichchinnatanu prerepistundi. pradhana granuel-sambandhita jaathi 15-kda protein, idhi proteolytic prosessing dwara 40-kda utpatti yokka carboxyl terminus nundi udbhavinchindani bhaavistunnaaru. eee janyu utpatti yokka vividha isopharmlaku daariteese pratyaamnaaya splissing vivarinchabadindi.

