
parvulin lanty peptidile-prolyl isomerase

parvulin-lanty peptidile-prolyl isomerase (prsa), putative proteiness maturation protein eah (ppma) gaa kooda suuchistaaru, bii vanti gram-positive bacterialo molecular chaperonga panichestundi. subtilis, ess. arius, ell. monocytogenlu mariyu ess. payojenlu. prassa proteinlalo atyanta samrakshinchabadina parvulin domine untundi, indulo peptidile-prolyl sis-trans isomerase (pipes) kaaryaacharana untundi, idhi bandham enn-terminalnu sis nundi trans varaku prolineku utprerakam cheyagaladu, ledhaa dheeniki viruddhamgaa, idhi protein madatalo retunu parimitam chese dasha. proteins madata pettadamlo sahaayapadataayani anumaaninchina foldays domine kooda prasa homolaglalo untundi, conny, parvulin domine maadirigaa kakunda, idhi ekkuvagaa samrakshinchabadadu. prassa proteins vivo mariyu inn vitrolo multimersnu yerparuchukune saamarthyaanni kaligi untaayi mariyu, dimerise chesinappudu, ensi domainla dwara anusandhaaninchabadina panjala vanti nirmaanaanni yerparustaayi. chaalaa gram-positive bacterialo oka prasa lanty protein matrame untundi, conny ell vanti konni jeevulu untaayi. monocytogens, bii. anthrasis mariyu ess. piogenlalo rendu praasalu untaayi.
function.
bii loe. itara gram-positive jeevulalo prasa homolaglatho poliste subtilis, prasa saadhaaranamgaa baga vargeekarinchabadutundi. sravinche proteinla digubadini prassa lekapovadam gananeeyamgaa prabhaavitam chestundani mariyu idhi saadhaarana perugudalaku avasaramani sravinche vislaeshanhalu choopinchaayi. ell loe. monocytogenlu, murine mouse namoonaalo rendu prasa janyuvulalo okati matrame tolaginchabadinappudu viralencelo 5-6 logg taggudala untundi. inca, prasa-ksheeninchina bacteria kanaalu antibioticsku nirodhakatanu taggistaayi, kana goda jeevajananamlo daani prameyam kaaranamgaa, mariyu anduvalla prasa antimicrobial lakshyanni cheravacchu.
gram-positive bacterialo sravinche proteinlanu madata pettadaniki mariyu sthireekarinchadaaniki praas homologs vanti paarvulinlu panicheestaayani maddatu ivvadaaniki aadharalu unnaayi. sell wall mariyu bacteria membrane madhya interfacelo panicheyadaaniki avi cytoplasm nundi sravistaayani prastuta dayta suuchistumdi. ikkada, avi lipidation dwara bacteria poraku mudipadi untaayi mariyu bacteria poraku prsaanu kotte avasheshaala mutation monomeric unitlalo phalitaalanu istundi, ayithe idhi mutate kanappudu prsa dimerise avutundi mariyu diamer roopam daani paniteeruku mukhyamainadi.
virus karakalu pradhanamgaa oka bahirgata sthithilo sekanu sthaanaantara maargamlo bayataku sravistaayi mariyu vyaadhikaarakamlo panicheyadaaniki puurtigaa madavali. vairasnu prothsahinchadaaniki sravinche proteinla yokka protein madatalo sahaayapadatamlo prassa proteinla paatra chikkukundi. adanamgaa, puurti biophilm nirmaanam, eetha gathi, ottidi nirodhakathatho paatu itara jeeva prakriyalalo prasa function chikkukundi.

