
monocrotophos

monocrotophos anedi organophosphate purugumandulu. idhi pakshulaku mariyu manavulaku teevramgaa vishapuuritam, kabatti idhi yuu. ess loe nishedhinchabadindi.ess., ii.yuu.bharatadesam mariyu aneka itara deshaalu.
upayoginchandi.
monocrotophos pradhanamgaa vyavasaayamlo saapekshamgaa choukaina purugumandulugaa upayoginchabadutundi. ayithe, idhi tarachugaa aatmahatyaku saadhanamgaa kooda upayoginchabadutundi. dheenini dosakayaku purugumandulugaa upayogistaaru.
bharatadesamloni beehaarloni oka paatasaalalo 23 mandhi paatasaala vidyaarthula maranaaniki kaaranamaina kalushita padaartham monocrotophos anie nammutaaru. vaaru 2013 joolailo bharatadesamloni saran jillaalo prabhutvam andinchina paatasaala bhojanam tinnaru, idhi eee purugumandula containerlo unchina noonelo tayaaru cheyabadindi.
vishapuuritam.
vanyapraanula kosam.
argentinalo swenson hocks pedda sankhyalo champadamtho sahaa vistrutamgaa pakshulanu champadam, monocrotophos vadakam phalitamgaa jarigindi.
diabetes.
genome biologylo prachurinchina oka adhyayanamlo, organophosphate purugumandula yokka gut microbiota madhyavartitva diabetogenic prabhavanni parisoedhakulu pradarsinchaaru. vaaru tama adhyayanamlo monocrotophosenu prototypical organophosphatega upayoginchaaru mariyu deerghakaalika teesukovadam samayamlo, monocrotophos gut microbiota dwara adhokaranam chendutundani mariyu glucose asahananiki kaaranamayye gluconiogenesis dwara tudi utpattulu glucozga maarchabadataayani pradarsinchaaru. eee adhyayanaalannii madurailooni graamaala nundi maanava namoonaalalo dhruvikarinchabaddayi.
cardiotoxicity.
iteevali adhyayanamlo, wistar elukalaku moodu vaaraala paatu pratiroojuu gonthu dwara noti dwara monocrotophos (0.36 mii. graa./kilola shareera baruvu) motaadu yokka <ii. dii. 1> ivvabadindi. monocrotophos icchina jantuvulu raktamlo telikapati hyperglycemia mariyu dyslipidemianu pradarsinchaayi. protein carbonyls, lipid peroxidation mariyu glutathione utpatti cheradam dwara cardiac aakseekarana ottidi erpadindi. cardiac markerlu (ctn-ii, sike-embi mariyu eldehetch) rakta plasmalo adhika sthaayilanu choopinchaayi, idhi cardiac kanajaalam debbatinadaanni suuchistumdi. gunde kanajaalam yokka hystopathology kandaraala fibers madhya anirdishta shotha maarpulu mariyu vaapu sankethaalanu choopinchadam dwara monocrotophos prerita kanajaala nashtam dhruveekarinchindi. anduvalla eee praathamika adhyayanam yokka phalitaalu elukalalo sudeerghakaalam monocrotophos teesukovadam valla kalige cardiotoxic prabhavanni vivaristaayi mariyu emsipi anedi swatantramaina mariyu saktivantamaina paryaavarana hridayanaala pramaada karakamga undavacchani suuchistunnaayi.
teevramaina prabhavalu.
pisi12 kanaalalo naraala perugudala karakam (50 ng/ml) prerepita kriyaatmaka bhedam nivedinchabadindi. monocrotophoscu guraina pisi12 kanaalalo mitochondria madhyavartitva apoptosisnu choopinche adhyayanalu jarigaayi. reactive oxygen jaatulu, lipid peroxidelu mariyu glutathione disulfide/taggina glutathione nishpattini enchukunna motaadula monocrotophoscu guraina kanaalalo gananeeyamaina prerana gamaninchabadindi. pisi12 kanaalu monocrotophoscu guraina taruvaata, cospace-3, cospace-9, baaks, pii53, pii21, puma mariyu cytochrome-sii yokka protein mariyu mrna vyakteekarana sthaayilu gananeeyamgaa niyantrinchabaddaayi, ayithe bcl-2, bcl-doubleu mariyu mcl-1 sthaayilu tagginchabaddaayi. tunel aseh, dna nicchena mariyu micronucleae induction adhika saandrata (10−5 mea) vadda pisi12 kanaalanu deerghakaalikamgaa monocrotophoscu bahirgatam cheyadam valla necrotic kanaala sankhya peragadam valla apoptotic sanghatanala sankhya taggutundani choopistundi. cytoplasm mariyu mitochondria madhya baaks mariyu cytochrome-sii proteinla monocrotophos-prerita sthaanaantaragamanam mitochondrial pora yokka paaragamyatalo monocrotophos paatranu dhruveekarinchindi. mitochondria madhyavartitva apoptosis prerana cospace cascade yokka perigina kaaryaacharana dwara nirdhaarinchabadindi. eee apoptotic maarpulu monocrotophos (10−5 mea) kuu guraina pisi12 kanaalalo enchukunna cytochrome pii450la (saip1eah1/1eah2,2bii1/2bii2,2ii1) yokka vyakteekarana yokka unnata sthaayilatho sahasambandham kaligi undavacchu.

