
pancreatic ilets

pancreatic ilets ledhaa langerhans yokka ilets anevi 1869loe german pathological anatomist paal langerhans kanugonna daani endocrine (harmon utpatti chese) kanaalanu kaligi unna pancreas praantaalu. pancreatic ilets pancreas valuemlo 1-2% nuu kaligi untaayi mariyu daani rakta pravaahamlo 10-15% nuu andukuntaayi. pancreatic ilets maanava clomum antataa saandrata margallo amarchabadi untaayi mariyu glucose yokka gvakriyalo mukhyamainavi.
nirmaanam.
aarogyakaramaina vayojana maanavuni clomum antataa sumaru 1 million dveepaalu pampinhee cheyabaddaayi, veetilo prati okkati sagatuna 0.2 mimi vyaasam kaligi untundi.928 prati dveepam chuttupakkala unna pancreatic kanajaalam nundi oka sannani peechu anusandhaana kanajaala gulika dwara vaeru cheyabadutundi, idhi migilina clomum antataa parasparam allina peechu anusandhaana kanajaalamtho nirantaramgaa untundi.: 928 
microanatomy.
pancreatic iletslo utpatti ayye harmonelu (kaneesam) aidu rakaala kanaala dwara neerugaa rakta pravaahamloki sravistaayi. eluka dveepaalalo, endocrine kana rakalu eee krindi vidhamgaa pampinhee cheyabadataayih
pancreatic ilets yokka cytoarchitecture jaatula madhya bhinnamgaa untundani gurtinchabadindi.
mukhyamgaa, elukala dveepaalu samuuhamlooni pradhana bhaagamlo insulin utpatti chese beata kanaala pradhana nishpatti mariyu chuttupakkala unna arudaina alfa, delta mariyu pipi kanaala dwara vargeekarinchabadinappatiki, maanava dveepaalu samuuhamloo alfa mariyu beata kanaalanu okadaanitoe okati sannihita sambandhamlo pradarsistaayi.
chinna dveepaalalo beata kanaala nishpatti jaatulanu batti maarutuu untundi, maanavulalo idhi 40-50% untundi. endocrine kanaalatoe paatu, stromal kanaalu (fibroblastlu), vascular kanaalu (endothelial kanaalu, perisaitlu), roganirodhaka kanaalu (granulocytelu, lymphocytelu, macrophaselu, dendritic kanaalu) mariyu naadii kanaalu unnaayi.
oka graamu dveepaaniki 5 nundi 6 millilitres/nimishaaniki pedda mottamlo raktam eee dveepaala gundaa pravahistundi. idhi clomum yokka exocrine kanajaalam kante 15 retlu ekkuva.
paracrine mariyu autocrine communication dwara dveepaalu okadaanikokati prabhaavitam cheyagalavu, mariyu beata kanaalu vidyut dwara aaru nundi edu itara beata kanaalatoe jatacheyabadataayi, conny itara kana rakaalato kaadu.
function.
pancreatic ilets yokka paracrine feedback system krindi nirmaanaanni kaligi untundih
pedda sankhyalo zii protein-coupled receptorlu (gpcr) pancreatic ilets nundi insulin, glucagon mariyu somatostatin sraavamnu niyantristaayi, mariyu eee gpcrlalo konni type-2 diabetes (riff glp-1 receptor agonistlu, dppv inhibitorlu) chikitsaku upayoginche aushadhaala lakshyalu.
vidyut karyakalapalu.
pancreatic ilets yokka vidyut karyakalapalu pyaach clamp paddhatulanu upayoginchi adhyayanam cheyabaddaayi. chekkuchedarani dveepaalalooni kanaala pravartana chedaragottabadina kanaala pravartanaku gananeeyamgaa bhinnamgaa untundani telindi.
clinical praamukhyata.
diabetes.
pancreatic ilets yokka beata kanaalu insulin sravistaayi, anduvalla diabetislo mukhyamaina paatra poeshistaayi. roganirodhaka daadula dwara avi naasanam avtayani bhaavistunnaaru.
pancreatic iletsloni beata kanaalu type 1 diabetislo swayam pratirakshaka prakriya dwara empika cheyabadina vidhamgaa naasanam cheyabadataayi kabatti, vaidyulu mariyu parisoedhakulu saareeraka beata kana paniteerunu punaruddharinche maargamgaa ilet maarpidini churukuga konasagistunnaru, idhi puurti clomum marpidi ledhaa krutrima klomanku pratyaamnaayaanni andistundi. 1970la praarambhamlo madhumeham avasaramayye insulin chikitsaku dveepa marpidi anedi oka aacharaneeya empikagaa udbhavinchindi, taruvaati moodu dasaabdaalalo sthiramaina purogati saadhinchindi.<reifer paeru = "".iteevali clinical trials asthiramaina type 1 diabetes rogulalo shavaala daata dveepaalanu naatina tarvaata insulin swaatantryam mariyu merugaina jeevakriya niyantrananu punarutpatti cheyavachani choopinchaayi.
adhika boddy maas index (bmi) unna vyaktulu marpidi samayamlo ekkuva saanketika samasyala kaaranamgaa pancreatic daatalu. ayithe, pedda clomum kaaranamgaa pedda sankhyalo dveepaalanu verucheyadam saadhyamavutundi, anduvalla avi dveepaalaku marinta tagina daatalu.
ilet maarpidilo eee vyaadhiki chikitsagaa avasaramaina beata kanaalatoe kuudina kanajaalam badilee matrame untundi. anduvalla idhi mottam clomum marpidi kante prayojanaanni suuchistumdi, idhi saanketikamgaa marinta demand kaligi untundi mariyu udaaharanaku, avayava nashtaniki daariteese clomum vaapu pramaadaanni kaligistundi. maroe prayojanam emitante rogulaku saadhaarana anaesthesia avasaram ledhu.
type 1 diabetisku ilet maarpidiki prastutam daata ailetla atidheya tiraskarananu nivaarinchadaaniki saktivantamaina roganirodhaka saktini anachiveyadam avasaram.
eee dveepaalu oka portal siraloki naatabadataayi, taruvaata kaaleyamlo naatabadataayi. portal sirala saakha raktam gaddakatte pramaadam mariyu marpidi chesina konni nimishala tarvaata ilet manugada yokka takkuva viluva untundi, endukante eee pradaesamloe vascular saandrata shastrachikitsa tarvaata antarjana dveepaala kante chaalaa nelalu takkuvagaa untundi. anduvalla, dveepam manugadaku neovascularization keelakam, udaaharanaku, dveepaalu mariyu vascular endothelial kanaala dwara utpatti cheyabadina wezf dwara maddatu istundi. ayithe, intraportal transplantationlo konni itara lopaalu unnaayi, anduvalla ilets implantation kosam merugaina suukshma vaataavaranaanni andinche itara pratyaamnaaya pradaesaalu pariseelinchabadutunnaayi. ilet transplant parisoedhana ilet encapsulation, cni-free (calcinurin-inhibitor) immunosuppression, ilet nashtam ledhaa ilet daata korata yokka biomarkerlapy kooda drushti pedutundi.
beata kanaala pratyaamnaaya muulam, vayojana muula kanaalu ledhaa puurveekula kanaala nundi utpannamayye insulin utpatti chese kanaalu marpidi kosam daata avayavaala koratanu adhigaminchadaaniki dohadam chestaayi. punarutpaadaka vaidya rangam vaegamgaa abhivruddhi chendutondi mariyu sameepa bhavishyattu kosam goppa aasanu andistundi. ayithe, type 1 diabetes anedi klomamloni beata kanaala swayam pratirakshaka naasanam phalitamgaa vastundi. anduvalla, samarthavanthamaina nivaaranaku beata sell punarutpaadaka vidhaanaalatho taginanta mariyu surakshitamaina roganirodhaka jokyaalanu militam chese varusa, samagra vidhanam avasaram. beata kanaala punarutpattiki bhavishyat vanarugaa unde aarogyakaramaina mariyu diabetic maanava mariyu eluka pancreatic ilets rendintiloonuu alfa kanaalu yaadrucchikamgaa vidhini maarchagalavani mariyu beata kanaalugaa maragalavani kooda niroopinchabadindi. vaastavaaniki, ilet padanirmaana shaastram mariyu endocrine bhedam neerugaa sambandham kaligi unnayani kanugonabadindi. endocrine progenitor kanaalu samanvayamlo valasa velli mogga lanty ilet puurvagaamulu ledhaa "peninsulas" nuu yerparustaayi, dheenilo alfa kanaalu dveepakalpa bayati poranu yerparustaayi mariyu beata kanaalu vaati krinda taruvaata erpadataayi. cryopreservation merugaina marpidi phalitaala kosam pancreatic ilets yokka sarafara golusunu meruguparustundani vaagdaanam chesindi. 
parisoedhana.
canabinoid grahakaalu langerhans yokka dveepaalalo vistrutamgaa vyakteekarinchabadataayi, mariyu aneka adhyayanalu pancreatic endocrine functionlaku sambandhinchi sibi1 verses sibi2 graahakaala yokka nirdishta pampinhee mariyu yantraamgaalanu parisoedhinchaayi, ikkada avi mukhyamaina homeostatic paatranu poeshistaayi, endukante endoconnabinoids pancreatic β-kanaala paniteeru, vistarana mariyu manugadanu, alaage insulin utpatti, sraavam mariyu nirodhakatanu niyantristaayi.

