disk shedding

disk shedding anedi retiinaalooni photoreceptor kanaalu punaruddharinchabade prakriya. photosensitive opsinlanu kaligi unna photoreceptorla bayati vibhaagamlo disk nirmaanaalu prati padhi rojulaku puurtigaa punaruddharinchabadataayi.
photoreceptorlu.
retina rendu rakaala photoreceptorlanu kaligi untundi-raad kanaalu mariyu cone kanaalu. kaanti drushtini madhyavartitvam chese sumaru 6-7 million sankuvulu unnaayi, avi retina madhyalo unna maculalo kendrikrutamai untaayi. sankuvula kante sunnitamaina sumaru 120 million raadlu unnaayi, anduvalla ivi scotopic drushtini madhyavartitvam chestaayi.
sakasherukapu prakaasa graheetalu moodu bhagaluga vibhajinchabaddaayih
diskulu.
prakaasavantamaina bayati vibhaagamlo vivikta pora discla shreni untundi.
raadlo undagaa, eee disclu uparitala poratho etuvanti pratyaksha anusandhanam kaligi undavu (iteevala erpadina konni besal disclu minaha, ivi uparitalamtho konasaagutaayi), cone yokka prakaasavantamaina pora uparitala poratho nirantaramgaa untundi. adhika-sunnitatva kaantini gurtinchadaaniki bayati vibhagam (oes) disclu rhodopsintho nindi untaayi. eee diskulu prati padhi rojulaku okasari puurtigaa bharti cheyabadataayi mariyu eee nirantara punaruddharana kanipinche jantuvu jeevitakaalam antataa konasaagutundi.
opsinlanu samslaeshanha chesina tarvaata, avi plasma poraku kalisipotayi, idhi antargatamgaa molakettutunna disclatho daadi chesi, bayati bhagapu discla yokka gattiga pyaak cheyabadina stacklanu yerparustundi. opsin anuvaadam nundi disclu erpadataaniki kevalam rendu gantalu padutundi.
chitlinchadam.
disk sheddingnu modatisaarigaa modatisaarigaa aarr. doubleu young varninchaaru. disclu vaati dhoora valasatho paatu paripakvam chendutaayi; paatha disclu dhoora kona vadda chedaragottabadataayi mariyu ksheenata kosam poruguna unna retina pigment epithelial (aarr. pii. ii) kanaalatoe kappabadi untaayi.
oka prarambha adhyayanam prakaram, raadlu chese vidhamgaa sankuvulu cone sheddingnu anubhavinchakapovachhu mariyu paramaanu bhaagaalanu vyaktigatamgaa bharti cheyadam dwara punaruddharinchavachhu. ayithe, itara adhyayanalu kaneesam "konni" ksheerada sankuvulu tama disclanu oka saadhaarana konasagutunna prakriyagaa tolagistaayani chuupistunnaayi.
pratiroojuu bayati bhaagam yokka podavulo padava vanthu kolpotundi, tadwara padhi rojula taruvaata mottam bayati bhaagam bharti cheyabadindi. prati dasalo niyantrana karakalu untaayi. disk assembly ekkuvagaa janyuparamgaa niyantrinchabadutundagaa, disk shedding mariyu tadupari aarpi phagocytosis kaanti mariyu ushnograta vanti paryaavarana kaarakaala dwara niyantrinchabadataayi.
naraala modulatorla prakaram, dopamine mariyu melatonin anevi chindinche samayam syrcadian layanu anusaristaayi. melatonin raatri samayamlo photoreceptorla dwara samslaeshanha cheyabadutundi, mariyu kaanti mariyu dopamine dwara nirodhinchabadutundi, kabatti cone disk sheddingnu prerepistundi. dopamine utpatti kaanti dwara prerepinchabadutundi mariyu cheekati mariyu melatonin dwara nirodhinchabadutundi, kabatti cone disk sheddingnu prerepistundi. mukhyamgaa, pagatipuuta raad disclu mariyu raatri samayamlo cone disclu tolaginchabadataayi.
yantraangam.
saampradaaya siddhaantaalu.
bayati bhaagamlo disk shedding yokka mottam yantraamgamlo oka buudida rangu praantam discla nirliptatanu sarigga prerepistundi mariyu avi oes nundi elaa ravana cheyabadataayi mariyu arpy kanaala dwara phagocytos cheyabadataayi.
konni adhyayanalu arpy kanaalu disk nirliptatanu aakraminchadaaniki mundu disk nii cheelchuthaayani, mariyu raad bayati vibhaagamlo churukaina prakriya disknu vaeru chestundani suuchistunnaayi. ayithe, itara adhyayanalu disk nirliptata samayamlo aarpi sell prakriyalu oes loki chorabadataanni gamaninchaayi. eee prakriyalu nirmanatmakamga phagocytosis samayamlo macrophasela dwara erpadina prakriyalanu pooli untaayi mariyu tadanugunamgaa sudopodia anie piluvabadataayi. eee sudopodia phagocytosis yokka kanajaalaalu anie mariyu avi disk nirliptatalo pratyaksha paatra pooshinchavacchani adhyayanam suuchimchimdi.
iteevali parisoedhana.
parisoedhana vacchina oka kaagitam moodava siddhaantaanni andistundi, idhi rhodopsin-lopam unna elukalu ossnu abhivruddhi cheyadamlo viphalamayyaayani soochinche iteevali aadhaaraalapai aadhaarapadindi. carnell parisoedhakulu phototransduction receptorga daani paathratho paatu, oes biogenesislo rhodopsin paatra undani oohinchaaru. oes abhivruddhilo rhodopsin yokka bhaagaswaamyaaniki antarleenamgaa unna paramaanu aadharam teliyakapoyinappatiki, rhodopsin yokka cytoplasmic sii-terminal thoka raad sell baadiilooni samslaeshanha pradaesam nundi oesku daani ravana kosam "chirunama sanketam" kaligi undani udbhavistunna aadharalu suuchistunnaayi.

