
asialoglycoprotein grahakam

asialoglycoprotein grahakaalu (eah. ess. zii. pii. aarr) anevi lectinlu, ivi asialoglycoprotein mariyu glycoproteinlanu bandhistaayi, veeti nundi galactose avasheshaalanu bahirgatam cheyadaaniki sialik aamlam tolaginchabadindi. ksheeradaala hepatocytes (kaaleya kanaalu) paie unna samagra pora proteins ayina grahakaalu, lakshya glycoproteinlanu prasarana nundi tolagistaayi. asialoglycoprotein grahakam hepatocytes uparitalampai adhika vyakteekarananu kaligi undani mariyu aneka maanava carcinoma kana rekhalanu kaligi undani niroopinchabadindi, idhi pittaasayam mariyu kadupu grandhi kanaala dwara kooda balaheenamgaa vyakteekarinchabadutundi. lactobionic aamlam anedi asialoglycoprotein grahakalanu vyakteekarinchae kanaalaku aushadha pampinhee kosam lakshya bhaagamgaa upayoginchabadindi.
asialoglycoprotein graahakamlo rendu upabhaagaalu untaayi, asialoglycoprotein grahakam 1 (eah. ess. zii. aarr. 1) mariyu asialoglycoprotein grahakam 2 (eah. ess. zii. aarr. 2). eee upabhaagaalu nirdishta uparitala bandham ledhaa endocytosisnu anumatinchadaaniki diamerlu, trimmerlu, tetramerlu vanti vividha chatushkona roopaalanu yerparustaayi. ASGR 1 pradhana upa vibhagam mariyu 8 exanlanu kaligi undhi mariyu sumaru 6 kb podavu untundi. asghar 2 anedi chinna upaghatakam mariyu 9 exanlanu kaligi untundi mariyu sumaru 13.5 kebi podavu untundi. 
charitra.
asialoglycoprotein grahakanni modatisaarigaa 1968loe morel mariyu itarulu vargeekarinchaaru. mariyu idhi gurtinchabadina modati ksheerada lectin. parisoedhakulu rediyodhaarmikamgaa-label cheyabadina seruloplasmannu badilee chesaaru, idhi protein yokka terminal sialik aamlanni tolaginchadaaniki neuraminidase enjaim dwara praticharyaku guraindi, idhi oka asialoglycoprotein nuu utpatti chestundi. rediyodhaarmika proteinnu kundellaloki injection icchina taruvaata, mottam asialoglycoprotein (proteinlo oka bhaagam kakunda) yokka rediyodhaarmikata raktam nundi kaaleyamloki twaragaa kadulutundi. protein yokka sialik aamlam tolaginchabadinappudu matrame raktam nundi kaaleyamloki eee vegavantamaina kadalika sambhavistundi; i.ii., protein bahirgatamaina galactose avasheshaanni kaligi unte (adhi saadhaaranamgaa sialik aamlamtho kappabadi untundi). anduvalla, oka grahakam aasiyaaloglaikoproteenlu gurtinchagaladani nirdhaarinchabadindi (i.ii., tama antima sialika aamlaalanu kolpoyina proteins) mariyu vaatini kaaleyaaniki ravana cheyadam dwara prasarana nundi tolaginchadam. 
function.
asialoglycoprotein grahakaalu galactosyl mariyu enn-acetylgalactosaminal kaligina uparitalaalanu utprerakaparachadaaniki panicheestaayi. marinta pratyaekamgaa, chaalaa ksheeradaalalo, asialoglycoprotein grahakam vaati chakkeralalo konnintini kaligi unna glycoproteinlanu, mukhyamgaa protein chivara nundi tolaginchabadina antima sialik aamlanni tolagistundi.
charya yokka yantraangam.
maanava asialoglycoprotein grahakaalu rendu unitlatho koodi untaayi, hetch1 mariyu hetch2. eee unitlalo prati okkati kaaleya kanam yokka cytoplasm lopala vaati enn-terminusnu kaligi untaayi mariyu extra cellular vaipu carbohydrate recognition domine (crd) untundi. calcium ayan-madhyavartitva paraspara charya dwara asialoglycoproteinlotho bandhinchadaaniki crd panichestundi. mukhyamgaa, asialoglycoprotein yokka antima chakkerala hydroxyl samuuhaalu (saadhaaranamgaa galactose) asialoglycoprotein grahakam yokka crd thoo hydrogen bandhaalanu yerparustaayi; eee hydrogen bandhaala saraina sthaanam mariyu soulabhyam ca2 + undatam valla sambhavistundi. 
espipiki sppr yokka anubandham.
espigipi-espigipi paraspara charya yokka anubandham espigipipai unna chakkerala sankhyatho sahaa karakalapai aadharapadi untundi. udaaharanaku, oka galactose unna eah. ess. zii. pii. ess. luu adhika viyojana sthiraamkaanni kaligi untaayi (i.ii., takkuva anubandha paraspara charya) aneka chakkeralatho jatacheyabadina oka eah. ess. zii. pii. thoo polchabadindi. ekkuva chakkerala samakshamlo eee perigina anubandham anedi eah. ess. zii. pii. aarr yokka carbohydrate gurtimpu domine mariyu eah. ess. zii. pii. paie chakkerala madhya marinta paraspara charyala erpadatam valla kaavacchu. paraspara charya yokka anubandham kooda antima galactose yokka maarpula dwara madhyavartitvam cheyabadutundi; udaaharanaku, enn-acetylgalactosamineto unna espigelu galactosto unna espijilatho poliste spgpr kosam adhika anubandha paraspara charyanu kaligi untaayi. 

