
kalakarudu

artmether anedi malaria chikitsaku upayoginche aushadham. suudi mandula roopamlo quinine kakunda teevramaina malaria kosam pratyaekamgaa upayogistaaru. peddavaarilo, idhi artesunate vale prabhaavavantamgaa undakapovachhu. idhi kandaraalalo injection dwara ivvabadutundi. idhi artemether/lumefantrine anie piluvabade lumefantrine thoo kalipi noti dwara kooda labhistundi.
artmether saapekshamgaa takkuva dushprabhaavaalanu kaligistundi. kramarahita hridaya spandana arudugaa sambhavinchavachhu. garbhadhaarana samayamlo upayoginchadam jantuvulalo hanikaram kaavacchu anae aadharalu unnappatikee, maanavulalo aandolanaku etuvanti aadharalu laevu. anduvalla prapancha aarogya samstha (evaru) garbhadhaarana samayamlo dheenini upayoginchaalani sifaarsu chestundi. idhi artemisinin taragati mandulalo undhi.
artmether kaneesam 1981 nundi adhyayanam cheyabadindi, mariyu 1987 nundi vaidya upayogamlo undhi. idhi prapancha aarogya samstha yokka avasaramaina aushadhaala jaabitaalo undhi.
vaidya upayogaalu.
artemether anedi "p" valla kalige sanklishtata laeni malariaku malaria nirodhaka aushadham. falsiparum "(mariyu chloroquin-nirodhaka" p. falsiparum ") ledhaa chloroquin-nirodhaka" p. vivax "paraannajeevulu. teevramaina malaria chikitsaku kooda artemethernu upayoginchavacchu.
prapancha aarogya samstha (evaru) saralamaina "p" chikitsanu sifaarsu chestundi. artemisinin aadhaarita kalayika chikitsato falsiparum. lumefantrintho kalipi icchina taruvaata, "p" yokka punahsthitini nivaarinchadaaniki 14 rojula primaquine niyamaavalini anusarinchavacchu. vivax "ledhaa" p. malaria paraannajeevulanu andaasayamloo veyandi mariyu puurti nivaarananu andinchandi.
praajeekvaanteltho kalipi upayoginchinappudu schistosomiasis yokka trematode infectionlaku chikitsa cheyadaaniki mariyu nivaarinchadaaniki kooda artemethernu upayoginchavacchu.
artemisinin utpannaalu pindam nashtam mariyu vaikalyamtho anubandhaanni choopinchina janthu adhyayanala aadhaaramgaa artemetherku fda dwara vargam sii rating ivvabadindi. ayithe, konni adhyayanalu haani kaliginche aadhaaraalanu choopinchavu.
dushprabhaavaalu.
saadhyamayye dushprabhavalalo broadycardia mariyu cuty viramam podigimpu vanti hridaya prabhavalu untaayi. alaage, janthu adhyayanaalalo kendra naadii vyavastha vishapuuritam kaavacchani choopabadindi.
aushadha paraspara charyalu.
lopinavir/ritonavir thoo kalayika utpattini upayoginchinappudu plasma artemether sthaayi takkuvagaa unnatlu kanugonabadindi. effavirange ledhaa neviraapintoe ekakaalamlo upayoginchadamto sambandham unna aushadha bahirgatam kooda taggindi.
artemether/lumefantrinnu saip3eah4nii nirodhinche mandulatho upayoginchakudadu.
artemether/lumefantrintho upayoginchinappudu harmonela garbhanirodhakaalu antha prabhaavavantamgaa undakapovachhu.
aushadha shaastram.
charya yokka yantraangam.
artemether anedi artemisinin utpannam mariyu artemisininla charya yokka yantraangam.
artmether aamla paraannajeevi aahara vaakyuullooni ferriprotoporphirin ikes (heam) ledhaa ferrous ayaanlatho sankarshana chendutundi mariyu cytotoxic radikal jaatulanu utpatti chestundi. 
peroxide kaligi unna aushadham yokka aamodinchabadina charyalo heam (haemoglobin ksheenata yokka upa utpatti) thoo daani paraspara charya untundi, idhi haemoglobin yokka proteolysis nundi teesukobadindi. eee paraspara charya vishapuurita oxygen mariyu carbon kendrikruta radicals erpadataaniki daariteestundi.
pratipaadita yantraamgaalalo okati, anty-accident mariyu metabolic enjaimlanu nirodhinchadam dwara, artemisinin utpannaalu kanampai aakseekarana mariyu jeevakriya ottidini kaligistaayi. prabhaavitamaina konni margalu glutathione mariyu glucose jeevakriyaku sambandhinchinavi kaavacchu. paryavasanamga, paraannajeevi yokka gayalu mariyu taggina perugudala phalitamgaa undavacchu.
arteristinine mandulu pfatp6nii nirodhinchadam dwara tama seedle charyanu nirvahistaayani maroka sambhaavya charya suuchistumdi. pfatp6 anedi cellular calcium saandratanu niyantrinche enjaim kabatti, daani panicheyakapovadam kanaala lopala calcium perukupovadaniki daariteestundi, idhi kramamga kanaala maranaaniki kaaranamavutundi.
pharmacokinetics.
aahaaramto artmether yokka shoshana 2 nundi 3 retlu merugupadutundi. idhi protein (95.4%) thoo chaalaa kattubadi untundi. artmether yokka garishta saandratalu paripalana tarvaata 2 gantala tarvaata kanipistaayi.
artmether maanava sareeramlo kriyaaseela metabolite, dihydroartemisinine, pradhanamgaa hepatic enjaimlu saip3eah4/5 dwara jeevakriya cheyabadutundi. maatru aushadham mariyu kriyaaseela metabolite rendoo sumaru 2 gantala sagam jeevitamto tolaginchabadataayi.
rasayana shaastram.
artemether anedi artemisinin yokka methyl eethar utpannam, idhi malaria nirodhaka mokka "artemisia yanuva" nundi verucheyabadina peroxide kaligina lactone. dheenini dihydroartemisinine methyl eethar anie kooda pilustaaru, conny daani saraina rasayana naamakaranam (+)-(3-alfa, 5-beata, 6-beata, 8-beata, 9-alfa, 12-beata, 12aarr)-decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12h-pyrano (4,3-zhe)-1,2-benzodiaxepine.
idhi saapekshamgaa lipophilic mariyu asthira aushadham, idhi plasmodium jeevi yokka pora ravana vyavasthanu prabhaavitam cheyadamtho paatu reactive free raadikalsnu srushtinchadam dwara panichestundi.

