
bisphenol eah yokka aarogya prabhavalu

bisphenol anedi bisphenol eah (bpa) yokka biomedical praamukhyata gurinchi aandolanalu mariyu charchalapai kendrikrutamai undhi, idhi konni aahara kantainarlatho sahaa konni viniyogadaaru utpattullo upayoginche paalimarlaku puurvagaami. bpa anedi endocrine distruptor anae parikalpanatho aandolanalu prarambhamayyayi, antey.ii. idhi endocrine harmonelanu anukaristundi mariyu anduvalla rasaayanamtho saareeraka sambandhamlo unna vyaktulapai analochita mariyu bahusha suduura prabhavalanu kaligi untundi.
2008 nundi, aneka prabhutvaalu daani bhadratanu parisoedhinchaayi, idhi kontamandi retailarlu paalii carbonate utpattulanu upasamharinchukovadaaniki prerepinchindi. yuu.ess. phud und drugg administration (fda) baby seesaalu mariyu shishu formula packaginglo bpa vaadakaaniki thana adhikaranni nilipivesindi, idhi market parityaagam aadhaaramgaa, bhadrata aadhaaramgaa kaadu. european union mariyu kenada baby seesaalalo bpa vadakanni nishedhinchaayi.
yuu.ess. 2014 praarambhamlo agency jaarii chesina maroe rendu adhyayanaalatho sahaa vistrutamaina parisoedhana aadhaaramgaa fda "aaharalalo sambhavinche prastuta sthaayilalo bpa surakshitamgaa undhi" anie perkondi. european phud safety authority (efsa) 2008,2009,2010,2011 mariyu 2015loe bpapy kotta shaastreeya samacharanni sameekshinchindih effsae nipunulu prati sandarbhamloonuu bpaku telisina sthaayi surakshitam anie vaari abhiprayanni savarinchadaaniki daariteese kotta aadhaaraalanu gurtinchalekapoyarani nirdhaarinchaaru; ayithe, effsae konni anischitulanu gurtistundi mariyu vaatini daryaaptu chestune untundi.
fibravari 2016loe, france bpnu chaalaa ekkuva aandolana kaliginche (esvihechsi) reach regulation condidate padaarthamgaa pratipaadinchaalani bhaavistunnatlu perkondi. european chemicals agency juun 2017loe eee pratipaadanaku angeekarinchindi.
utpatti.
rasayana parisrama utpatti chese bpa parimaanam kaaranamgaa bpa vivaadam oopandukundi. 1980laloe bpa yokka prapancha utpatti saamarthyam 1 million tannulu, mariyu 2009loe 2.2 million tannulaku paiga undhi. idhi adhika utpatti parimaanamlo unde rasayanamu. 2003loe, yuu.ess. viniyogam 856,000 tannulu, veetilo 72 saatam paalii carbonate plaastik tayaareeki mariyu 21 saatam epoxy resinlaku vellevi. yuu loe.ess.utpatti cheyabadina bpalo 5 saatam kante takkuva aahara samparka anuvartanaallo upayoginchabadutundi, conny tayaarugaa unna aahara parisramalo mariyu ammakaala raseedulu vanti mudrana anuvartanaallo migilipoyindi. 20 fibravari 2018naa, "packaging digest" "kaneesam 90 saatam" aahara dabbaalalo bpa ledani nivedinchindi.
sanghatana.
paarisraamika utpattulalo bpa arudugaa kanipistundihi idhi sthiramgaa polymeric nirmaanamloo bandhinchabadutundi. anduvalla bahirgatam gurinchi aandolanalu pradhanamgaa jalavisleshana dwara eee polymerlu mariyu vaati nundi utpannamayye plaastik vastuvula ksheenatapai drushti pedataayi.
bpa nundi erpadina paalii carbonate plaastik, baby mariyu neeti seesaalu, creeda parikaraalu, vaidya mariyu dantha parikaraalu, dantha puuraka sealantlu, sidi mariyu dvd, gruha electronics, kallajodu katakamulu, foundry castinglu mariyu neeti gottala lining vanti vividha rakaala saadhaarana utpattulanu tayaaru cheyadaaniki upayoginchabadutundi.
polysulphonelu mariyu polyether keatonela samshlaeshanhaloo, konni plasticiserlalo antioxidantga mariyu pvsilo polymerisation inhibitorga kooda bpa upayoginchabadutundi. bisphenol eah nundi utpannamaina epoxy resinlanu daadaapu anni aahara mariyu paaneeyaala dabbala lopali bhaagamlo puutalugaa upayogistaaru; ayithe, bpa aarogya samasyala kaaranamgaa, japaanlo epoxy puutanu ekkuvagaa pempudu jantuvula pora dwara bharti chesaaru.
carbonless coppy paper mariyu thermal point off sael raseedu paperlo bisphenol eah anedi ishtapade rangu developer. thermal paperlo upayoginchinappudu, bpa "free" gaa untundi (i.ii.vivikta, polymerised kaani) bpa, idhi bpa resin ledhaa plasticga polymerise cheyabadina daanikante bahirgatam cheyadaaniki ekkuvagaa andubaatulo untundi. nirvahistunnappudu, thermal peparloni bpnu charmaniki badilee cheyavachu, mariyu chetulapai avasheshaalanu yaadrucchikamgaa chethitho noti sparsha dwara teesukovacchane aandolana undhi. inca, charma shoshana mottam maanava bahirgataaniki kontha chinna bhaganni dohadapadutundani konni adhyayanalu suuchistunnaayi. kaagitamlo bpa vadakam recycle chesina kaagitam pravaahamlo mariyu pallapullo bpa unikiki kooda dohadam cheyavachani european dayta suuchistumdi. united stateslo thermal paperlo upayoginche bpa parimaanaaniki etuvanti anchanaalu laenappatikee, paschima airopalo, 2005/2006 loe thermal paperlo upayoginchina bpa parimaanam samvatsaraaniki 1,890 tannulu, ayithe mottam utpatti samvatsaraaniki 1,150,000 tannulugaa anchanaa veyabadindi. (2012 epa draft paper nundi teesukunna ganaamkaalu.) kaagitam recyclinglo bpa vyaapti mariyu perukupoye sambhaavyatanu adhyayanalu namodu chestaayi, oohaatmaka nishedham tarvaata kooda kaagitam recycling looplo dasabdaluga daani unikini suuchistunnaayi. epoxy resinlo bpa undavacchu ledhaa undakapovachhu, mariyu konni ruut kenal vidhanalalo gutta perchanu bandhinchadaaniki upayoginchabadutundi.
biomedical charitra.
1930la praarambhamlo, british jeevarasaayana shaastravetta edward charless dods bpnu krutrima eestrojengaa pareekshinchaaru, conny idhi estradiol kante 37,000 retlu takkuva prabhaavavantamgaa undani kanugonnaru. dods chivariki nirmanatmakamga saaruupya sammelanam, diethylstillbestrall (dess) nuu abhivruddhi chesindi, idhi cancer kaliginche pramaadam kaaranamgaa nishedhinchabade varaku mahilalu mariyu jantuvulalo synthetic eastrogen aushadhamgaa upayoginchabadindi; maanavulalo dess vaadakampai nishedham 1971loe vachindi mariyu jantuvulalo, 1979loe. bpnu eppuduu aushadhamgaa upayoginchaledu. sahaja eastrogen prabhavalanu anukarinche bpa saamarthyam bpa mariyu estradiol rendintipai final samuuhaala saaruupyata nundi udbhavinchindi, idhi eee synthetic anuvunu sareeramlo eestrogenik maargaalanu prerepinchadaaniki veelu kalpistundi. saadhaaranamgaa bpa maadirigaane final kaligina anuvulu balaheenamaina eestrogenik karyakalapalanu nirvahistaayi, anduvalla idhi endocrine distruptor (edd) mariyu eestrogenik rasayanamga kooda pariganinchabadutundi. genoeestrogenlu anedi maanavulu mariyu jantuvulalo punarutpatti abhivruddhini niyantrinche sankethaalanu niyantrinche netvarkku antaraayam kaliginche saamarthyam kaaranamgaa rasayana bpa kindaki saripoye maroka vargam.
1997loe, prayogasaala jantuvulalo takkuva motaadu bpa bahirgatam yokka pratikuula prabhavalu modata pratipaadinchabaddaayi. aadhunika adhyayanalu garbhadhaarana samayamlo mariyu abhivruddhi samayamlo bpaku gurikavadam valla kalige aarogya samasyalaku sambhaavya sambandhaalanu kanugonadam praarambhinchaayi. united stateslo prajaarogya niyantrana charitra mariyu nishedhaalapai rasayana tayaareedaarula pratispandanalanu chudandi. 2014 natiki, bpnu nishedhinchaalaa vadda anae daanipai parisoedhanalu mariyu charchalu konasagutunnayi.
2007 adhyayanam bisphenol eah mariyu eastrogen-sambandhita grahakam γ (err-γ) madhya paraspara charyanu parisoedhimchimdi. eee anatha grahakam (antarjanita ligand teliyanidi) transcription yokka constitutive activatorga pravartistundi. bPA anedi err-γ (dissociation constant = 5.5 nm) thoo balamgaa bandhinchinatlu anipistundi, conny er kii matrame balaheenamgaa untundi. bPA anedi error-γ thoo bandhinchadam daani besal constitutive activityni samrakshistundi. idhi 4-hydroxytamoxifen (aphymoxiphen) anae serm nundi nishkriyam kakunda kooda rakshinchagaladu. idhi bpa genoeestrogenga panichese yantraangam kaavacchu. sariiramlooni vividha bhagalalo error-gm yokka vibhina vyakteekarana bisphenol eah prabhavalalo vaividhyaalaku kaaranam kaavacchu. udaaharanaku, maayalo adhika saandrataloo error-gm kanugonabadindi, eee kanajaalamlo adhika bisphenol perukupovadam gurinchi nivedikalanu vivaristundi. bpa kooda jiper (gpr30) yokka agonistga panichestundani kanugonabadindi.
bhadrata.
aarogya prabhavalu.
european phud safety authority prakaram "prastuta bahirgata sthaayilalo bpa yea vayasula viniyogadaarulaku (puttaboye pillalu, sisuvulu mariyu koumaaradasalo unna vaaritho sahaa) aarogya pramaadaanni kaliginchadu". conny 2017loe european chemicals agency endocrine distruptorga daani lakshanaala kaaranamgaa bpnu chaalaa ekkuva aandolana kaliginche padaardhamgaa jabita cheyaalani teelchindi.
2012loe, united states phud und drugg administration (fda) 12 nelala kante takkuva vayassu unna pillala kosam uddesinchina baby seesaalalo bpa vadakanni nishedhinchindi. sahaja vanarula rakshana mandali eee charya saripodani, anni aahara packaging nundi bpnu nishedhinchaalsina avasaram undani perkondi. aaharaanni kaligi unna utpattulalo upayogam kosam bpa bhadrataku agency maddatu istundani fda perkondi.
yuu.ess. paryaavarana parirakshana samstha (epa) kooda bpa anedi aarogya samasya kaadani perkondi. 2011loe, united kingdom yokka aahara pramaanaala samstha yokka pradhana shaastravetta andrew wadge, 2011 yuu paie vyakhyaaninchaadu.ess. vayojana maanavulu bpaku aahara bahirgatampai adhyayanam, "idhi itara swatantra adhyayanalanu dhruveekaristundi mariyu bpa vaegamgaa grahinchabadutundani, nirvisheekarana cheyabadindani mariyu maanavula nundi tolaginchabadutundani aadhaaraalanu jodistundi-anduvalla idhi aarogya samasya kaadu."
endocrine society 2015loe matladutu, konasagutunna prayogasaala parisoedhana phalitaalu paryaavaranamloo endocrine-antaraayam kaliginche rasaayanaala yokka sambhaavya pramaadaala gurinchi aandolanaku aadharalu icchaayani-bpatho sahaa-mariyu mundu jaagratta suutram aadhaaramgaa eee padaarthaalanu anchanaa veyadam mariyu kathinamgaa niyantrinchadam konasaaginchaalani chepparu. bii. pii. eah valla kalige sambhaavya haani shaastreeya charchaku sambandhinchina amsamani, bii. pii. eah. bahirgatam mariyu punarutpatti mariyu abhivruddhi prabhavalu mariyu jeevakriya vyaadhulatoe sahaa pratikuula maanava aarogya prabhaavaala madhya sambandham kaaranamgaa tadupari parisoedhanaku praadhaanyata undani saahityam yokka 2016 sameeksha perkondi.
united states nipunula panel teermaanaalu.
2007loe, yuu.ess. bpapy saahityam yokka shaastreeya anchanaa vaeyadaaniki uttara karolinaloni chappel kondaku nipunulanu federal prabhutvam aahvaaninchindi. bisphenol thoo sambandham unna rangaalalo muppai enimidi mandhi nipunulu uttara karolinaloni chappel kondalo bpapy aneka vandala adhyayanalanu sameekshinchadaaniki samavesamayyaru, veetilo chaalaa varaku samuuham sabhyulu nirvahinchaaru. samavesam mugimpulo, samuuham chappel hill ekaabhipraaya prakatnanu vidudala chesindi, idhi "maanava sareeramlo kanipinche saandratala vadda bpa prostate, rommu, vrushanhaalu, ksheerada grandhulu, shareera parimaanam, medadu nirmaanam mariyu rasayana shaastram mariyu prayogasaala jantuvula pravartanalo samsthaagata maarpulatoe mudipadi untundi."chappel hill ekaabhipraaya prakatana prayogasaala prayogaalalo aneka jantuvulaku haani kaliginche vaati kante prajalalo sagatu bpa sthaayilu ekkuvagaa unnayani perkondi. paryaavaranamloo ledhaa maanavulalo bpa sthiramgaa laenappatikee, biomonitoring sarvelu bahirgatam nirantaramgaa untundani suuchistunnaayi. idhi samasyaatmakamainadi endukante teevramaina janthu bahirgata adhyayanalu bpaku rojuvaaree maanava bahirgataanni anchanaa vaeyadaaniki upayoginchabadataayi, mariyu janthu namoonaalalo bpa pharmacokineticsnu pariseelinchina adhyayanalu nirantaram takkuva-sthaayi bahirgataalanu anusarinchaledu. seeram mariyu itara shareera dravaalalo bpa sthaayila kolata bpa teesukovadam lekkinchina daanikante chaalaa ekkuvagaa unde avakaasaalanu suuchistumdani ledhaa bpa konni paristhitulalo (garbham vantivi) bioacumulate cheyagaladani rachayitalu telipaaru. chappel hill prakatnanu anusarinchi, yuu. ess. national toxicology programme-center pharr dhi evaluation off risks tuu human reproduction (entipi-serr), maroka saahitya anchanaanu spaansar chesindi. 2008loe vidudala chesina nivedika, "bisphenol eah maanava abhivruddhini marchagala avakaasaanni tosipuchalemu" anie perkondi. eee nivedika unnappatikee, US phud und drugg administration (FDA) bpa task fores (april 2008loe erpadindi) bpa kaligi unna utpattulu surakshitamainavani nirdhaarinchindi. 2009loe, bisphenol eah paie fda sains boardu upasangham, fda nivedikanu sameekshinchadaaniki ketaayinchina oka bahya kamitee, "fda kathinamaina ledhaa vistrutamaina bahirgata anchanaa veyadamlo viphalamaindani" nirdhaarinchindi, idhi us environmental protection agency (epa) vaari swantha anchanaa vaeyadaaniki daariteesindi.
united states federal intergency working group (efidableu) 2 december 2010 vidudalalo bpa exposurenu tagginche lakshyanni kaligi undhi, idhi americanlandari aarogyaanni meruguparachadaaniki vaari 2020 aarogyakaramaina prajala jaateeya lakshyalu.
jeevakriya vyaadhi.
aneka janthu adhyayanalu endocrine antaraayam kaliginche rasayanalu (bpatho sahaa) mariyu oobakaayam madhya sambandhaanni pradarsinchaayi. ayithe, maanavulalo bisphenol bahirgatam mariyu oobakaayam madhya sambandham aspashtamgaa undhi. cohort adhyayanalu prasavapurva bpa bahirgatam mariyu 7 samvatsaraala vayassulo shareera kovvu saatam peragadam mariyu 9 samvatsaraala vayassulo bmi peragadam anae anubandham undani choopinchaayi. anni adhyayanalu bpa bahirgatam mariyu oobakaayam madhya saanukuula sambandhaanni choopinchaledu, jeevakriya vyaadhulapai bpa prabhavalapai tadupari adhyayanalu phalitampai adhi kaligi unna edainaa prabhavanni tolaginchadaaniki aaharaanni parigananaloki teesukoovaali. oobakaayam pramaadaanni penchadaaniki bpa bahirgatam kosam pratipaadita yantraamgaalalo bpa-prerita thyroid panicheyakapovadam, ppr-gaama grahakanni sakriyam cheyadam mariyu tine pravartananu niyantrinche naadii circuitla antaraayam vantivi unnaayi. bpa sahaja harmon 17bii-estradiolnu anukarinchadam dwara panichestundi. gatamlo bpa eastrogen yokka balaheenamaina anukaranagaa pariganinchabadindi, ayithe kotta aadharalu idhi saktivantamaina anukarana anie suuchistunnaayi. idhi eastrogen graahakaalato bandhinchinappudu, idhi kendrakam velupala praarambhamayye pratyaamnaaya eestrogenik prabhavalanu prerepistundi. bpa dwara prerepinchabadina eee vibhina maargam janthu adhyayanaalalo glucose mariyu lipid jeevakriyanu maarustundani choopabadindi.
abhivruddhi yokka vividha dasalalo bpa bahirgatam yokka vividha prabhavalu unnaayi. yuktavayasulo, bpa bahirgatam baruvunu prabhaavitam cheyakunda insulin sunnitatvaanni mariyu insulin vidudalanu savaristundi.
thyroid paniteeru.
bisphenol-eah thyroid harmon graahakamtho bandhistundani mariyu bahusha daani vidhulapai empika chesina prabhavalanu kaligi untundani 2007 sameeksha teelchindi.
paryaavarana rasayanalu mariyu thyroid paniteeru gurinchi 2009 sameeksha triodothyroninpy bpa prabhaavaala gurinchi aandolanalanu levanettindi mariyu "andubaatulo unna aadharalu paalaka samsthalu thyroid-antaraayam kaliginche rasaayanaala vadakanni niyantrinchaalsina avasaram undani suuchistunnaayi, mukhyamgaa atuvanti upayogaalu garbhinii streelu, navjata sisuvulu mariyu chinna pillala bahirgataaniki sambandhinchinavi" anie teelchindi.
2009 sameeksha thyroid harmon charyapai bpa pratikuula prabhavalanu sangrahinchindi.
2016 cases controll studylo vayojana mahilala samuuhamloo moothra bpa sthaayilu mariyu perigina tshech sthaayilu (thyroid-stimulating harmon) madhya gananeeyamaina sambandham undani kanugonnaru.
naraala prabhavalu.
parimita epidemiological aadharalu garbhaasayamlo mariyu baalyamlo bpaku gurikavadam maanavulalo paelavamaina pravartanaa phalitaalato mudipadi undani suuchistunnaayi. pillalalo adhika sthaayi aandolana, niraasa, hyperactivity mariyu dookudu thoo bahirgatam sambandham kaligi undavacchu. yuu yokka national toxicology programme (entipi) dwara samavesamaina panel.ess. pindam mariyu sisuvu medadu abhivruddhi mariyu pravartanapai bpa prabhaavaala gurinchi "kontha aandolana" undani national institute off health nirnayinchindi. janavari 2010loe, entipi nivedika aadhaaramgaa, fda adhe sthaayi aandolananu vyaktam chesindi.
eastrogen (genoeestrogenlu) nuu anukarinche itara rasaayanaala maadirigaane bpnu naadii vyavasthalooni oka aatagadiga pariganinchaalani, idhi bahula maargaala dwara daani vidhulanu niyantrinchagaladu ledhaa maarchagaladani 2007 saahitya sameeksha teelchindi. 2008loe janthu parisoedhana sameekshalo takkuva motaadu bpa talli bahirgatam elukalalo naraala pravartana abhivruddhiki deerghakaalika parinaamaalanu kaligistundani kanugonnaru.
2009 sameeksha anteroventral periventricular nucleuspie bpa prabhavam gurinchi aandolanalanu levanettindi.
dopaminergic vyavasthaku antaraayam.
maanava palgonevari 2008 sameeksha prakaram bpa eestrogenik charyanu anukaristundi mariyu mesolymbic dopamine charyanu penchadaaniki vividha dopaminergic prakriyalanu prabhaavitam chestundi, phalitamgaa hyperactivity, shraddha lopaalu mariyu durviniyogam chese aushadhaala patla sunnitatvam perugutundi.
cancer.
hoose infosan prakaram, yuu kinda nirvahinchina carcinogenicity adhyayanalu.ess. jaateeya toxicology karyakramam maga elukalalo leukemia mariyu vrushanha madhyantara kana kanitulalo perugudalanu choopinchindi. ayithe, gamanika prakaram, "niyantranala nundi sanghatanalalo chinna vyatyaasaala yokka anumaanaaspada ganaanka praamukhyata kaaranamgaa eee adhyayanalu sambhaavya cancer pramaadaaniki nammadagina saakshyamgaa pariganinchabadaledu."
bisphenol eah cancer pramaadaanni penchutundani 2010 sameeksha teelchindi.
purushulalo prostate cancer erpadatam anedi bpa exposureku neerugaa anulomaanupaatamlo untundani aneka adhyayanalu aadhaaraalanu chuuputunnaayi. prostate cancertho badhapaduthunna maga vyaktilo moothramlo niyantrana samuuhamloo kanipinche saandratalaku viruddhamgaa bpa adhika saandrata unnatlu kanugonabadindi. prostate cancer kanaala kana vistarananu prerepinche bpa saamarthyam kaaranamgaa eee sahasambandham undavacchu.
rommu cancer.
bpaku guraina elukalu mariyu praimetlapai aneka adhyayanaalalo rommu cancerku ekkuva avakaasam unnatlu kanugonabadindi. edemaina, maanavulalo rommu cancer abhivruddhipai bpa choope prabhavam aspashtamgaa undhi, endukante oka vyakti yokka bpa bahirgatam vaari jeevitakaalamlo lekkinchadam kashtam. phenolic nirmaanaanni kaligi unna bpa, rommu mariyu prostate cancer vanti endocrine rugmatalanu sulabhataram chese agonist mariyu antagonistic endocrine graahakaalato anubandhaanni choopinchindi. itara endocrine rugmatalalo vandhyatvam, polycystic ovaree syndrome mariyu akaala yuktavayassu unnaayi.
aneka inn vitro adhyayanaalalo kanugonna vivaraala prakaram rommu cancer kanaalalo ekkuva aakseekarana ottidi bpa exposureku neerugaa anulomaanupaatamlo unnatlu kanugonabadindi. adanamgaa, bii. pii. eah. kii pani sambandhita bahirgatam, mariyu rutukramam aagipoyina mahilalu rommu cancer sambhavam perugutundani suuchimchaaru.
charya yokka yantraangam.
bpa anedi endocrine distruptor, antey bpa eastrogen (ligand) kuu samaanamaina nirmaanaanni kaligi untundi mariyu eastrogen grahakam era mariyu erbitatho bandhinchi daanini sakriyam cheyagaladu.
eastrogen hydrophobic mariyu plasma pora dwara mariyu lakshya kanamloki vyaapinchagaladu. eastrogen graahakaaniki eastradiol bandham anedi grahakam yokka ligand bandham domine nundi heat shock proteinnu vidudala chestundi, idhi dimerisationku kaaranamavutundi. nuclear localization signal ligand-receptor complexenu nucleusku lakshyamgaa chesukuntundi, ikkada idhi dnapy lakshya janyuvula promoter lopala eastrogen pratispandana muulakaalanu bandhinchagaladu. tadanantaram, kanaala vistaranalo palgonna vaatitho sahaa janyuvula pratilekhanaanni anumatinche vividha saha kaarakaalanu niyamistaaru.
bpa adhika ushnogratalu ledhaa ph loe maarpulaku gurainappudu, bpa monomerlanu anusandhaaninche ester bandham hydrolyse cheyabadutundi. free bpa appudu era mariyu erbita binding saitla kosam eestrojentho pootiipadutumdi. bpa grahakanni vijayavantamgaa bandhinchinappudu, idhi eretho sankarshana chendutundi mariyu doubluenty-4 mariyu rankl vanti lakshya janyuvula vyakteekarananu penchutundi; muula kana vistarana mariyu carcinogenesislo rendu keelaka aatagaallu. bpa pii53 nii nishkriyam chestundani kooda choopabadindi, idhi apoptosisnu prerepistundi kabatti kaniti erpadataanni nirodhistundi.
santanotpatti.
2022 natiki, prastuta aadharalu bpa sthaayilu, takkuva veerya naanhyata, taggina chalanasheelata mariyu veerya aparipakvata perugudala madhya saanukuula sahasambandhaanni chuuputaayi. bpa bahirgatam maanava santanotpattipai pratikuula prabhavalanu chooputundane aalochanaku maddatu ivvadaaniki taatkaalika aadharalu unnaayi. punaraavruta garbhasravam bpa sthaayilatho mudipadi undaa anie konni adhyayanalu parisoedhinchaayi. bpaku gurikavadam anedi endometrial hyperplasia yokka adhika retlatho mudipadi unnatlu kanipinchadu. bpaku gurikavadam anedi endometrial hyperplasia yokka adhika retlatho mudipadi unnatlu kanipinchadu. 2009 cohart adhyayanam ivf guddu punaruddharanaku guraina mahilala moothra bpa saandratanu andakosa vidudalaku viloma sahasambandhamtho mudipettindi. 3va roeju efshetch (iu/ell) loe prati unit perugudalaku, tirigi pondina andakosala sankhyalo sagatuna 9 taggudala undani adhyayanam kanugondi. janthu adhyayanaalalo kanipinche saanukuula sahasambandhaalu janta santanotpatti kosam bpa yokka nirantara parisoedhanaku haamii istayi.
punarviniyoga plaastiklu, aahara mariyu paaneeyaala container linerlu, baby seesaalu, neeti nirodhaka dustulu vanti viniyogadaaru utpattula dwara paryaavaranamloo sarvavyaapti chendutundi. idhi moothram, raktam, amneotic dravam, talli paalu mariyu taadu raktamlo kanipinche edisigaa gurtinchabadindi. 20-40 vayassu madhya saaravantamaina mariyu vandhyatvangala mahilala madhya rakta bpa mariyu thalet sthaayilanu polchadam, gyaas chromatographic-maas spectrometrini upayoginchi bpa, thalet mariyu paridheeya sirala raktamlo vaati jeevakriya mottaanni vislaeshimchadam, vandhyatvangala mahilallo, alaage pcos (polycystic ovarian syndrome) unna mahilallo mariyu endometriosis unna mahilallo seeram bpa sthaayini gananeeyamgaa penchindi.
meotic spindlesnu kaligi unna microtubles yokka nirmaana samagratalo maarpula dwara andaasaya paniteerunu lakshyamgaa chesukovadam dwara bpa transgenerational prabhavanni chooputundi. bpa kalushitaalu amneotic dravam gundaa velataayi, ivi pindam abhivruddhilo steroidogenesisnu marchagalavu. andakosa paripakvata vaiphalyam alaage santanotpatti vaiphalyam phalitamgaa idhi transgenerational prabhaavaaniki daariteestundi mariyu moodava taram santaanaanni prabhaavitam chestundi
laingika charya.
adhika bpa bahirgatam anedi purushula laingika paniteeru taggadam gurinchi sweeya-nivedikalanu penchadamtho mudipadi undhi, ayithe eee sambandhaanni pariseelinchae konni adhyayanalu nirvahinchabaddaayi.
ubbasam.
elukalapai adhyayanalu bpa bahirgatam mariyu ubbasam madhya sambandhaanni kanugonnayi; 2010loe elukalapai jaripina oka adhyayanam prakaram traaguneetiloo 10 microgram/ml bpaku prasavaanantara bahirgatam anedi allergy sunnitatvam mariyu swaasanaala vaapu mariyu ubbasam yokka janthu namoonaalo pratispandananu penchutundi. jaamaa pediatricslo prachurinchina oka adhyayanamlo bpaku prasavapurva bahirgatam kooda kontamandi chinna pillalalo oopiritittula saamarthyam taggadamtho mudipadi undani kanugonnaru. eee adhyayanamlo 398 talli-sisuvu jantalu unnaayi mariyu bpa saandratalanu gurtinchadaaniki vaari moothra namuunaalanu pariseelinchaaru. bpalo prati 10 retlu perugudala swaasalo guraka vachhe avakaasaalalo 55 saatam perugudalato mudipadi undani vaaru adhyayanam kanugonnaru. garbhadhaarana samayamlo bpa yokka saandrata ekkuvagaa undatam valla naalugu samvatsaraala kante takkuva vayassu unna pillalalo oopiritittula saamarthyam taggutundi, conny 5 samvatsaraala vayassulo eee sambandham adrusyamaindi. maryland school off medicine vishwavidhyaalayamloni pediatrics associate professor matladutu, "garbhadhaarana samayamlo bahirgatam kavadam, tarvaata kaadu, bpaku klishtamaina samayam anipistundi, bahusha idhi oopiritittula abhivruddhiki sahayapade mukhyamaina maargaalanu prabhaavitam chestondi."
2013loe columbia center pharr childrance environmental healthloni saastravettala parisoedhanaloo kooda eee sammelanam mariyu ubbasam vachhe pramaadam madhya sambandhaanni kanugonnaru. 3, 5 mariyu 7 samvatsaraala vayassulo adhika sthaayi bpa unna pillalu 5 mariyu 12 samvatsaraala madhya vayassulo unnappudu ubbasam abhivruddhi chendhe avakaasaalu perigaayani parisoedhanaa brundam nivedinchindi. eee adhyayanamlo pillalu bpa bahirgatam yokka adhe yekagratanu kaligi unnaaru.bidda. daa. columbia vishwavidyaalaya vaidya kendramlo bodhakudu cathleen donohue matladutu, "vaaru chaalaa saadhaaranamaina, bpa takkuva motaadulo ubbasam pramaadaanni chuusaaru."paryaavarana rasayanalu mariyu pillala aarogyaanni adhyayanam chese kimm harley, shaastreeya american jarnallo vyaakhyaanistuu, bpa ubbasam ledhaa swaasalo gurakku kaaranamavutundani adhyayanam chuupimchanappatikii," idhi oka mukhyamaina adhyayanam endukante bpa roganirodhaka pratispandana mariyu ubbasamnu elaa prabhaavitam chestundane daani gurinchi prastutam manaku peddagaa teliyadu...vaaru vividha vayasulalo bpnu kolicharu, ubbasam mariyu swaasanaalaalanu aneka paayintla vadda kolicharu, inca sthiramaina anubandhaalanu kanugonnaru."
janthu parisoedhana.
bisphenol eah yokka eestrogenisiteeki modati sakshyam 1930laloe elukalapai nirvahinchina prayogaala nundi vachindi, conny 1997 varaku prayogasaala jantuvulapai takkuva motaadu bahirgatam valla pratikuula prabhavalu modata nivedinchabadaledu.
bisphenol eah anedi eestrojennu anukarinchagala endocrine distruptor mariyu idhi janthu adhyayanaalalo pratikuula aarogya prabhavalanu kaligistundani choopabadindi. bisphenol eah sahaja harmon vale adhe eastrogen graahakamtho bandhinchadam mariyu sakriyam cheyadam dwara estradiol harmon yokka nirmaanam mariyu paniteerunu daggaragaa anukaristundi. prarambha abhivruddhi dasalu daani prabhaavaalaku atyadhika sunnitatvam kaligina kaalamgaa kanipistaayi.
2008 nundi jarigina oka adhyayanam navjata elukalalo bisphenol eah yokka rakta sthaayilu inject cheyabadina ledhaa teesukunnappatiki okela untaayani nirdhaarinchindi.
prastuta U.ess. epa dwara nirnayinchabadina maanava bahirgata parimiti 50 microgram/kilolu/roeju.
2010 vyaakhyaanamlo saastravettala brundam "toxicological sciences" loe prachurinchabadina takkuva motaadu bpa exposurenu pareekshinchadaaniki roopondinchina adhyayananni mariyu adhe journal taruvaata sampaadakeeyaanni vimarsinchindi, idhi adhyayanamlo upayoginchina elukalu eestrojenku sunnitamgaa levani mariyu bpa kaligina polycabonate bonula vadakam vanti itara samasyalanu kaligi unnayani, ayithe rachayitalu angeekarinchaledani perkondi.
sariiramlooni vividha bhagalalo error-gm yokka vibhina vyakteekarana bisphenol eah prabhavalalo vaividhyaalaku kaaranam kaavacchu. udaaharanaku, maayalo adhika saandrataloo error-gm kanugonabadindi, eee kanajaalamlo adhika bisphenol perukupovadam gurinchi nivedikalanu vivaristundi.
paryaavarana prabhavalu.
2010loe, yuu.ess. paryaavarana parirakshana samstha etaa oka million poundla bpa paryaavaranamloki vidudalavutundani nivedinchindi. prii-consumer mariyu post-consumer leaching dwara bpa paryaavaranamloki vidudala cheyavachu. paryaavaranamloki viniyogadaarula mundu konam nundi parichayam cheyadaaniki saadhaarana margalu neerugaa rasayana plaastiklu, kotu mariyu maraka tayaareedaarulu, casting isukalo bpnu upayoginche foundrylu ledhaa bpa mariyu bpa kaligina utpattula ravana. munisipal muruguneeti suddhi karmagarala nundi vyardhaalu, vyavasaayamlo upayoginche neetipaarudala gottalu, samudram dwara vachhe plaastik chettha, plaastik, kaagitam mariyu loha vyardhaala nundi parokshamgaa leaching, mariyu kaagitam ledhaa material recycling companyla nundi post-consumer bpa vyardhaalu vastaayi. 4. 5 rojula vegavantamaina matti mariyu neeti ardha-jeevitam mariyu oka roeju kante takkuva gaali ardha-jeevitam unnappatikee, bpa yokka sarvavyaapti dheenini mukhyamaina kalushya karakam chestundi. bpa neeru mariyu matti nundi takkuva aaviri retunu kaligi undhi, idhi jeevaadhokaranam mariyu jeeva-sanchayam gurinchi takkuva aandolana unnappatikee samasyalanu andistundi. bpa vaataavaranamloo takkuva asthiratanu kaligi untundi mariyu 5.00 mariyu 5.32 pascals madhya takkuva aaviri peedanam kaligi untundi. bpa sumaru 120 mii. graa/lii. adhika neetilo karige saamarthyaanni kaligi untundi mariyu paryaavaranamloo daani praticharyalalo ekkuva bhaagam jaleeyamainavi. oka aasaktikaramaina vaastavam emitante, bpa dummu mandithe adhi mandedi, conny gaalilo paeludu padaarthaala saandrata takkuvagaa untundi. alaage, jaleeya draavanaalaloo, bpa 250 nm kante ekkuva tarangadairghyala shoshananu choopinchindi.
bpa yokka sarvavyaapta swabhaavam eee sammelanaanni adhyayanam cheyadaaniki mukhyamaina kalushya karakamga chestundi, endukante idhi bacteria symbiant "sinorhizobium meliloti" thoo anubandhinchabadina kayagura mokkala muulaala vadda natrajani sthireekaranaku antaraayam kaligistundani choopabadindi."2013 adhyayanam kooda bpa bahirgatam kaaranamgaa mokkala aarogyamlo maarpulanu gamaninchindi. eee adhyayanam soyabean molakalanu bpa yokka vividha saandratalaku bahirgatam chesindi mariyu vaerla perugudala, nitrate utpatti, ammonium utpatti mariyu nitrate reductase mariyu nitrite reductase karyakalapalalo maarpulanu chusindi. bpa takkuva motaadulo, muulaala perugudala merugupadindi, moolaalalo nitrate parimaanam perigindi, moolaalalo ammonium parimaanam taggindi mariyu nitrate mariyu nitrite reductase karyakalapalu maaraledu. ayithe, bpa yokka gananeeyamaina adhika saandratala vadda, nitrate saandrata perugudala mariyu nitrite mariyu nitrate reductase karyakalapalalo taggudala minaha annintikee vyatiraeka prabhavalu kanipinchaayi. natrajani anedi mokkala poeshaka padaardham, conny mokkala perugudala mariyu abhivruddhiki kooda aadharam. bpa yokka maarutunna saandratalu paryaavarana vyavastha yokka paryaavarana saastraaniki, alaage mokkalanu viniyoginchadaaniki utpatti chesthe manavulaku hanikaram.
madhya-dakshina chainaalooni jiangjiang nadhi nundi vividha mokkalatho 2006loe jaripina oka adhyayanam prakaram, ushnograta perugudalato avakshepanapai soshinchabadina bpa parimaanam kooda taggadam kanipinchindi. saadhaaranamgaa, ushnograta perige koddi, oka sammelanam yokka neetilo karige saamarthyam perugutundi. anduvalla, ghana dasaloki pravesinche sorbet parimaanam samathoulya binduvu vadda taggutundi. avakshepanapai bpa yokka adhishoshana prakriya exothermic anie, molar formation entholpy, δh°, negative anie, free energy δg°, negative anie, molar entropy, δs°, positive anie kooda gamaninchabadindi. idhi bpa yokka adhishoshanam entholpy dwara nadapabadutundani suuchistumdi. perugutunna pihech thoo bpa yokka adhishoshanam kooda taggutundani gamaninchabadindi.
united stateslo nirvahinchina 2005 adhyayanam prakaram munisipal water treatment plantlalo suddhi chesetappudu bpa yokka 91-98% nuu neeti nundi tolaginchavacchu. bpa yokka jaleeya praticharyala gurinchi marinta vivaranaatmaka vivarana krinda bpa vibhagam yokka ksheenatalo gamaninchavacchu. ayinappatikee, uparitala neeti vyavasthalo bpa yokka 2009 meta-vislaeshanha united states mariyu airopaloni uparitala neeru mariyu avakshepanalo bpa unnatlu choopinchindi. 2011loe kenada paryaavaranam prakaram, "bpa prastutam munisipal muruguneetilo kanipistundi. [...]takkuva sthaayilalo, bisphenol eah kalakramena chepalu mariyu jeevulaku haani kaliginchagaladani praathamika anchanaa choopistundi."
bpa jala jeevulalo perugudala, punarutpatti mariyu abhivruddhini prabhaavitam chestundi. manchineeti jeevulalo, chepalu atyanta sunnitamaina jaatulugaa kanipistaayi. chepalu, jala akasherukaalu, ubhayacharaalu mariyu sareesrupaalalo endocrine-sambandhita prabhaavaalaku aadharalu teevramaina vishapuuritataku avasaramaina vaati kante takkuva paryaavarana sambandhita bahirgata sthaayilalo nivedinchabaddaayi. endocrine-sambandhita prabhaavaala kosam nivedinchabadina viluvalalo vistrutamaina vaividhyam undhi, conny chaalaa varaku 1 microgram/lii nundi 1 mii. graa/lii paridhiloo untaayi.
2009loe raayal society prachurinchina vanyapraanulapai plasticiserla jeeva prabhaavaala sameeksha, jala mariyu bhoogola analyds, molasklu, crustatianlu, keetakaalu, chepalu mariyu ubhayacharaalapai drushti saarinchi, bpa anni adhyayanam chesina janthu samoohaalalo punarutpattini prabhaavitam chestundani, crustatianlu mariyu ubhayacharaalalo abhivruddhini balaheenaparustundani mariyu janyu vairudhyaalanu prerepistundani teelchindi.
sakasherukaalu.
bpnu endocrine distruptor compound (edisi) anie pilustaaru mariyu sakasherukaalapai pradhana naraala prabhavalanu kaligi untundi. adhyayanam chesina sakasheruka jaatulanu batti, teesukovadam mariyu bpaku gurikavadam yokka document prabhavalu bhinnamgaa undavacchu. gbrafish vanti jaatulalo, bpa parshwa rekhanu prabhaavitam chestundi, idhi indriya avagahanaku keelakam mariyu gunde mariyu asthipanjara kandaraala jeevakriyanu niyantrinche janyuvula vyakteekarananu, alaage insulin sraavam niyantrananu prabhaavitam cheyavachu. jala sakasherukaalu mukhyamgaa punarutpattilo bpa dwara prabhaavitamavutaayi. vistruta mukku gala kaiman, kaiman latirostrislo, lingam saadhaaranamgaa guddu podige ushnograta dwara nirnayinchabadutundi. vaari gudlu bpaku guraina chota oka adhyayanam nirvahinchabadindi. modati sett sumaru 1000 microgramula/guddu vadda bahirgatamaindi mariyu santaanam anthaa aadadi. gudlu 90 microgramula/guddu vadda takkuva saandratatoe bahirgatamainappudu, utpatti cheyabadina santaanam magavaaru. eee maga santaanam antaraayam kaliginchina seminiferous gottalanu pradarsinchindi. elukalalo, talli aaharam adhyayanam cheyabadindi mariyu konni abhivruddhi dasalalo bpaku guraina santaanampai pradhana prabhavanni chooputundani kanugonabadindi. maanavulapai pratyaksha adhyayanalu laevu, ayithe, sakasherukaalapai adhyayanalu dheeniki sambhaavya haani kaliginchavacchani suuchistunnaayi.
punarutpatti prabhavalu.
bisphenol eah (bpa) anedi paryaavarana vyavasthaku antaraayam kaliginche paryaavarana kalushyam, sakasherukaalalo atyanta lothaina prabhavalanu gamaninchavacchu. bpa pallapu pradaesaala nundi paaripovadam dwara paryaavaranamloki chorabadutundi, kabatti eee kaaranamgaa, idhi ekkuvagaa neetilo kanipistundi. anduvalla jala sakasherukaalu eee rakamaina kalushyam valla ekkuvagaa prabhaavitamavutaayi. jala sakasherukaalu tama moppalu ledhaa charmam dwara bpnu peelchukunna tarvaata, avi pradhanamgaa cellular sthaayilo bpa dwara prabhaavitamavutaayi, ivi vaati eastrogen sthaayilanu prabhaavitam chestaayi. bpa eastrogen graahakaalato bandhistundi mariyu vyatiraeka prabhavanni kaligi untundi, antey idhi utpatti ayye eastrogen mottaanni taggistundi. punarutpatti vidhulanu niyantrinchadaaniki, gonadotropin vidudala chese harmon (gnrhech) vidudala avutundi. idhi purushulu mariyu streelalo laingika avayavaala paripakvataku sahaayapadutundi. maroe adhyayanamlo barbus ess. pii. anie kanugonnaru., aparipakva barbels, bpa jaadalatho oka nadiloe linga bheda lakshanaalanu vyaktam chesindi. vaariki oogonia, spermatogonia mariyu spermatocytes unna gonads undevi. bpa prerepinchaledani, conny eee lingaantara padanirmaana vyakteekaranalaku dohadapadindani parisoedhakulu nirdhaarinchaaru. 1 microgram/lii bpaku guraina taruvaata, salmo trutta, braun trout, veerya saandrata mariyu chalanaseelatanu tagginchindi. pimephales promelas, fyaat head minolalo, veerya utpatti taggindi. rendu jaatulu kooda 2 microgram/lii mariyu 5 microgram/lii bpaku gurayyayi mariyu dheeni phalitamgaa chepalaku andotsargamu alasyam ledhaa andotsargamu jaragaledu.
arudaina minov ayina vayojana aada gobiocypris raarusnu upayoginchi oka adhyayanam nirvahinchabadindi. chepalu 14 rojulu mariyu 35 rojula paatu 5 microgram/lii, 15 microgram/lii mariyu 50 microgram/lii bpaku gurayyayi. 35 rojula paatu atyadhika mottamlo bpa (50 microgram/lii) kuu guraina samuuham andakosala abhivruddhipai anachiveyabadina prabhavalanu choopinchindani phalitaalu choopinchaayi. anni samuuhaalu hepatic vitrogenin transcription (vtg) paie uddeepana prabhavanni chuupaayani kooda idhi choopinchindi. sakasherukaalu paryaavarana eestrojenlaku gurayyayani vtg suuchistumdi. bpa (5 microgram/ell & 15 microgram/ell) takkuva saandrataku guraina samuuhaalu andaasaya steroidogenic janyuvulalo perugudalanu choopinchaayi. intalo, bpa (50 microgram/lii) adhika saandrataku guraina samuuham andaasaya steroidogenic janyuvulalo taggudalanu choopinchindi. 
sahaja paristhitulalo bpa bahirgatam valla jala sakasherukaalu saadhaaranamgaa prabhaavitamainappatikii, prayogaatmaka eluka namuunaalanu upayoginchi bpa itara sakasherukaalanu elaa prabhaavitam chestundo parisoedhakulu tarachugaa telusukuntaaru. iravai samvatsaraala kritam nirvahinchina oka adhyayanamlo, pramaadavasaattu bpa bahirgatam jarigindi. idhi chromosome asaadhaarana gudla perugudalaku daariteesindi. idhi ksheeradaalapai itara prabhavalanu kaligistundane prasnanu parisoedhakulu adagadaniki daariteesindi. bpa santanotpatti mariyu laingika avayavaala paripakvata vanti meotic maarpulaku daariteestundani idhi choopinchindi. eee rakamaina bahirgatam utparivartanalaku daariteestundani mariyu bahula taraalanu prabhaavitam cheyagaladani saastravettalu grahinchadam praarambhinchaaru. eee kaaranamgaa, "bpa free" utpattulu tayaaru cheyadam praarambhinchaayi, conny deenni cheyadaaniki, bps upayoginchabadutondi. bps kuu gurikavadam valana jaigotic abhivruddhiki mundu utparivartanalu perigaayani, idhi bpa vale pramaadakaramainadani choopistundani oka adhyayanam nirvahinchabadindi.
pravartanaa prabhavalu.
sakasherukaala pravartanapai, mukhyamgaa vaati indriya prosessing vyavasthalalo bpa pradhana prabhavalanu chooputundi. gbrafishlo bpa endocrine vyavasthalo signalingku antaraayam kaligistundi mariyu shravana abhivruddhi mariyu paniteerunu prabhaavitam chestundi. maanava chevi maadirigaane, gbrafish parshwa rekha anie piluvabade indriya avayavam kaligi untundi, idhi vividha rakaala kampanaalanu gurtistundi. parshwa rekhaloni juttu kanaalu bpa yokka vishapuurita prabhaavaalaku chaalaa sunnitamgaa untaayi mariyu saadhaaranamgaa bpa nundi champabadataayi; chepalu juttu kanaalanu tirigi penchagalavu conny bpa vaatini samarthavantamgaa punarutpatti cheyagala saamarthyaanni tagginchindi. puurtigaa panichese parshwa rekha laeni chepalu pravartanaa maarpulanu kaligi untayih vetade pramaadam ekkuvagaa untundi, vaetanu gurtinchadam taggutundi mariyu punarutpatti saamardhyalu taggutaayi. chepala maadirigaa kakunda, ksheeradaalu neerugaa bahirgatamaite chevitivallayye pramaadam undhi.
alaage endocrine distruptor compound (edisi), bpa naraala prasarananu nirodhistundani kanugonabadindi. kappa (raanaa tigrina) yokka sandhivaata naraalalo, bpa vaegamgaa-vaahaka sammelanam charya sambhaavyata (cap) nii nirodhistundi. sciatic naraala yokka plasma poralo kanipinche eastrogen grahakaalu bpa mariyu inhibit cap dwara prabhaavitamavutaayi. ayithe, eastrogen grahakaalu matrame nirodhaaniki kaaranam kaadu, bpa eestrojennu prabhaavitam cheyakunda naraala vidhulanu nirodhinchagaladu. 
elukalapai chesina oka adhyayanam prakaram, edisigaa bpa pravartanaa prabhaavaalaku agonist/virodhigaa panichestundi. bpa abhivruddhi sthithilo bahirgatamaina maga elukalalo anveshanhaatmaka mariyu praadaesika pravartanalalo taggudalaku kaaranamaindi. magavaarini bahirgatam cheyadaaniki, garbhinii streelaku aahaaramlo bpa tinipinchaaru, elukalanu magavaaritho poolchaaru, vaari tallulaku phytoeestrogen rahita ctl aaharam icchaaru. abhivruddhi dasalo bpa bahirgatam ayina maga elukalu itara maga elukalu unnappudu praadesikamgaa unde avakaasam takkuvagaa undedi. bpa bahirgatam lingam mariyu jaatulapai aadhaarapadina pravartana yokka pravartananu maarchindi. eee teermaanaalu bpa laingikamgaa enchukunna lakshanaalaku kaaranamavutundane aalochanaku maddatu ichhe suuchanalu. antekakunda, talli aaharam mariyu abhivruddhi elukalanu bpaku bahirgatam cheyadam, haani kaliginchavacchu mariyu laingika dviruupa pratispandanalaku daariteeyavachchu.
jaateeya mariyu antarjaateeya samsthala sthaanaalu.
prapancha aarogya samstha.
november 2009loe, naadii mariyu pravartanaa vyavastha mariyu chinna pillalaku bahirgatam cheyadampai drushti saarinchi, takkuva motaadu bpa bahirgatam aarogya prabhavalanu anchanaa vaeyadaaniki 2010loe nipunula sampradimpulanu nirvahinchanunnatlu prakatinchaaru. bisphenol-eah vadakanni parimitam cheyadam ledhaa nishedhinchadam vanti kotta nibandhanalu aevee levani 2010loe nipunula brundam sifaarasu chesindi, "prajaarogya charyalanu praarambhinchadam anedi akalamga untundi" anie perkondi."
united states.
2013loe, fda thana websitelo ilaa post chesindi "bpa surakshitamgaa undaa? avunu. shaastreeya aadhaaraala yokka fda yokka konasagutunna bhadrata sameeksha aadhaaramgaa, andubaatulo unna samacharam aahara containerlu mariyu packaginglo aamodinchabadina upayogaala kosam bpa yokka bhadrataku maddatu istundi. prajalu takkuva sthaayi bpaku guravutaaru, endukante, aneka packaging bhagala maadirigaane, chaalaa takkuva mottamlo bpa aahara packaging nundi aaharaalu ledhaa paaneeyaalaloki maaravacchu."2014loe sameekarinchabadina agency nipunula brundam chesina munupati moodu sameekshala aadhaaramgaa fda oka prakatnanu vidudala chesindi," "bpapy saahityam mariyu dayta sameeksha kosam tudi nivedika" "loe, eee kotta vishapuurita dayta mariyu adhyayanala phalitaalu motaadu-prabhavam sthaayini mariyu ippatike unna noel (5 mii. graa/kejee bidablue/roeju; noti bahirgatam) nuu prabhaavitam cheyavu"."
australia mariyu newzealand.
2009loe australia mariyu newzealand aahara bhadrata samstha (aahara pramaanaalu australia newzealand) tayaareedaarula suuchanalanu anusaristhe bisphenol, baby seesaalato etuvanti aarogya pramaadaanni chudaledu, endukante bahirgatam sthaayilu chaalaa takkuvagaa unnaayi mariyu gananeeyamaina aarogya pramaadaanni kaliginchavu. baby seesaalalo bpnu upayoginchadaanni nilipiveyaalani videshee tayaareedaarulu teesukunna charya swachchanda charya, niyantrakaala nirdishta charya phalitamgaa kaadu" anie idhi jodinchindi."tallidandrulaku aandolanalu unte gaaju baby seesaalanu upayoginchaalani 2008loe suuchimchimdi.
2012loe australia prabhutvam paalii carbonate baby seesaalalo bpa vadakam nundi swachchanda dasanu pravesapettindi.
kenada.
april 2008loe, aarogya kenada pratikuula aarogya prabhavalu oohinchabadanappatiki, formula-feed sisuvulaku bhadrata yokka anchu chaalaa takkuvagaa undani nirdhaarinchindi mariyu rasayananni maanava aarogyaaniki mariyu paryaavaranaaniki 'vishapuuritamainadi' gaa vargeekarinchaalani pratipaadinchindi."bhadrata samasyala kaaranamgaa bisphenol eah kaligina polycarbonate baby seesaala digumati, ammakam mariyu prakatanalanu nishedhinchaalane kenada uddesaanni kenada aarogya mantri prakatinchaaru, mariyu lohapu dabbaalalo pyaak chesina baby formula yokka bpa kalushyanni tagginche maargaalanu parisoedhimchaaru. april 2008 nundi vacchina tadupari vaartaa nivedikalu chaalaa mandhi retailarlu tama almarala nundi paalii carbonate madyapaana utpattulanu tolaginchinatlu choopinchaayi.
18 october 2008naa, health kenada "navjata sisuvulu mariyu sisuvulaku bisphenol bahirgatam anedi prabhavalanu kaliginche sthaayila kante takkuvagaa undhi" mariyu "saadhaarana prajalu aandolana chendaalsina avasaram ledhu" anie perkondi.
2010loe kenada paryaavarana vibhagam bpnu "vishapuurita padaardham" gaa prakatinchindi mariyu kenadian paryaavarana parirakshana chattam, 1999looni schedule 1loe cherchindi.
european union.
european commission mariyu european phud safety authority (efsa) prachurinchina 2008 european union risk assessment report, paalii carbonate plaastik mariyu epoxy resinlu vanti aadhaarita utpattulu viniyogadaarulaku mariyu paryaavaranaaniki uddesinchina vidhamgaa upayoginchinappudu surakshitamgaa untaayani teelchindi. october 2008 natiki, laangu adhyayanam prachurinchabadina taruvaata, shareera baruvu yokka bpa kosam prastuta sahinchadagina rojuvaaree teesukovadam (tdi) sthaayini savarinchadaaniki adhyayanam etuvanti aadhaaraalanu andinchaledani nirdhaaristuu ephsa oka prakatana vidudala chesindi.
2009 december 22naa, european union paryaavarana mantrulu endocrine distrupterlaku gurikavadam valla pratikuula prabhavalanu chuuputunna iteevali adhyayanaalapai aandolana vyaktam chestu oka prakatana vidudala chesaaru.
2010 septembarulo, european phud safety authority (efsa) "iteevali vishapuurita dayta yokka samagra moolyaankanam [...] taruvaata muginchindi...] yea kotta adhyayananni gurtinchalekapoyamani, idhi prastuta tdi yokka savaranaku pilupunistundi ". abhivruddhi chendutunna jantuvulapai nirvahinchina konni adhyayanalu, mukhyamgaa medadulo jeevarasaayana maarpulu, roganirodhaka-niyantrana prabhavalu mariyu rommu kanitulaku merugaina grahanaseelata vanti vishapuurita sambandhita prabhavalanu bpa-sambandhita prabhavalanu suuchimchaayani panel perkondi, ayithe aaa adhyayanaalalo aneka lopaalu unnayani bhaavinchindi, kabatti maanava aarogyaaniki eee phalitaala yokka auchityaanni anchanaa veyalekapoyindi.
aarogya mariyu viniyogadaarula vidhaanaaniki baadhyata vahinche commissioner zaan dolly prakaram, 2010 november 25naa, european union executive commission sendriya sammelanaanni kaligi unna polycarbonate baby seesaala tayaareeni nishedhinchaalani mariyu marketing mariyu market placementnu nishedhinchaalani yochistunnatlu telipindi. dheeniki majority european union prabhutvaalu maddatu icchaayi. eee nishedhaanni vaidya parisoedhana mandali yokka maanava punarutpatti shaastra vibhaagaaniki chendina richard sharp atigaa pratispandinchinatlu pilicharu, eee charyanu samarthinche nammadagina aadharalu aevee tamaku teliyavani, shaastreeya praatipadikana kakunda raajakeeya praatipadikana chesinatlu vimarsinchaaru.
2011 janavarilo anni european deshaalalo baby seesaala vadakam nishedhinchabadindi.
iteevali parisoedhanalanu sameekshinchina taruvaata, 2012loe effsae bpaku gurikaavadamtoe kalige maanava pramaadaalanu tirigi anchanaa veyaalani nirnayam teesukundi. vaaru juulai 2013loe bpaku viniyogadaarula bahirgatam gurinchi musaida anchanaanu puurti chesaaru mariyu aaa samayamlo tudi nivedikanu roopondinchadamlo sahaayapadataaniki anni vaataadaarula nundi praja inputnu koraru, idhi 2014loe puurtavutumdani bhaavistunnaaru.
janavari 2014loe, effsae musaida abhiprayam yokka rendava bhaganni samarpinchindi, idhi bpa valla kalige maanava aarogya pramaadaalanu charchinchindi. musaida abhipraayamtho paatu enimidi vaaraala praja sampradimpulu jarigaayi mariyu bpaku sambandhinchina kaaleyam mariyu moothrapindaalapai pratikuula prabhavalanu kooda chaerchaaru. dheeni nundi prastuta tdini savarinchaalani sifaarsu cheyabadindi. janavari 2015loe, jaateeya saasanasabhalu chattalanu roopondistunnanduna, tdini rojuku 50 microgramula/kilola shareera baruvu nundi 4 micrograamulaku tagginchinatlu efsa suuchimchimdi.
12 december 2016naa european union commission thermal paper vaadakaaniki sambandhinchi kotta niyantrananu jaarii chesindi. eee kotta niyantrana prakaram, thermal paper kaligi unna vaatini 2020 janavari 2 tarvaata european union marketlo unchalemu. eee niyantrana 2017 janavari 2 nundi amalloki vachindi, conny moodu samvatsaraala parivartana kaalam undhi.
12 janavari 2017naa, bpnu chaalaa ekkuva aandolana kaliginche padaarthaala (esvihechsi) abhyardhula jaabitaalo chaerchaaru. abhyardhula ess. vii. hetch. sii jabita anedi european unionlo rasaayanaala digumati mariyu viniyogaanni parimitam chese disagaa modati adugu. european chemical agency ess. vii. hetch. sii hodaanu ketayinchinatlayite, oka utpattilo 0.01% kante ekkuva saandratatoe bpa unikini konugoludaarudiki (viniyogadaaru mariyu vyapara konugoludaarulaku ververu niyamaalato) bahirgatam cheyali. fibravari 2016loe, france 8 augustu 2016 natiki bii. pii. eah. nii abhyardhigaa ess. vii. hetch. sii. gaa pratipaadinchaalani bhaavistunnatlu prakatinchindi.
denmark.
2009 maeloe, danish paarlamentu baby seesaalalo bpa vadakanni nishedhinche teermaanaanni aamodinchindi, idhi april 2010 natiki amalu cheyabadaledu. marchi 2010loe, aarogya mantri taatkaalika nishedhaanni prakatinchaaru.
belgium.
marchi 2010loe, senator phillip mahoux aahara contact plaastiklaloo bpnu nishedhinche chattanni pratipaadinchaaru. mae 2011loe, senatorlu dominic tillmans mariyu jackwess brochi thermal paper nundi bpnu nishedhinchadaaniki chattanni pratipaadinchaaru.
france.
2010 fibravari 5naa, french phud safety agency (afsa) bpa yokka aarogya pramaadaala gurinchi munupati anchanaalanu prasninchindi, mukhyamgaa garbhaasayamlo bahirgatam ayina taruvaata mariyu jeevitam yokka modati nelallo eluka kukkalalo gamaninchina pravartanaa prabhaavaalaku sambandhinchi. 2010 eprillo, bpa kaligina aahara utpattulaku merugaina lebullanu sweekarinchaalani afsa suuchimchimdi.
2010 marchi 24naa, french senate baby seesaala nundi bpnu nishedhinche chattam pratipaadananu ekagreevamgaa aamodinchindi. jaateeya assembly (diguva sabha) 23 juun 2010naa eee vachananni aamodinchindi, idhi 2 juulai 2010 nundi vartinche chattamgaa undhi. 12 october 2011naa, french jaateeya assembly 2013loe 3 samvatsaraala kante takkuva vayassu unna pillalanu lakshyamgaa chesukunna utpattulalo bisphenol eah vadakanni nishedhinche chattanni, mariyu 2014loe anni aahara containerla kosam ootu vesindi.
9 october 2012naa, french senate 2015 samvatsaraaniki bisphenol eah thoo sahaa anni aahara containerla tayari, digumati, egumati mariyu marketingnu nilipivese chatta pratipaadananu ekagreevamgaa aamodinchindi. 3 samvatsaraala kante takkuva vayassu unna pillala kosam roopondinchina aahara utpattula kosam 2013loe bisphenol eah nishedham konasaginchabadindi.
germany.
19 september 2008naa, german federal institute pharr risk assessment (bundesinstitute pharr recobevertung, bfr) long adhyayanam aadhaaramgaa bisphenol a kosam prastuta pramaada anchanaanu maarchadaaniki etuvanti kaaranam ledani perkondi.
october 2009loe, german paryaavarana samstha bund pharr umvelt und natureschutz duechland pillala utpattulu, mukhyamgaa pasifierlu mariyu aahaaramto sambandham unna utpattulaku bpapy nishedham vidhinchaalani abhyardhinchindi. dheeniki pratispandanagaa, kontamandi tayaareedaarulu swachchandamgaa samasyaatmaka pasifaiyarlanu market nundi tolaginchaaru.
netherlands.
2016 marchi 3naa, (nvdablue) aarogya, sankshema mariyu creeda mantri mariyu aardhika vyavahaaraala kaaryadarsiki, bpnu bahirangamgaa teesukovadam gurinchi, mukhyamgaa garbhinii ledhaa tallipaalu ichhe mahilalu vanti haani kaliginche samuuhaalaku, mariyu 10 samvatsaraala kante takkuva vayassu unna pillalu vanti roganirodhaka vyavasthalanu abhivruddhi chestunna vaariki heccharika sifaarsulanu jaarii chesindi. idhi iteevala prachurinchina parisoedhanaku pratispandanagaa mariyu european aahara bhadrata adhikaram cherukunna teermaanaalaku pratispandanagaa jarigindi. vaaru sifaarsu chese garishta sahinchadagina viniyogaaniki anugunamgaa, thaaguneetilo bpa saandratanu 0.2 microgram/lii kante takkuvagaa tagginchaalani kooda idhi pilupunicchindi.
switzerland.
fibravari 2009loe, itara aarogya samsthala nivedikala aadhaaramgaa, prajaarogyam kosam swiss federal karyalayam, aaharam nundi bisphenol eah teesukovadam valla navjata sisuvulu mariyu sisuvulatoe sahaa viniyogadaarulaku etuvanti pramaadam ledani perkondi. ayithe, adhe prakatanalo, paalii carbonate baby seesaalanu mariyu jabita cheyabadina pratyaamnaayaalanu sarigga upayoginchaalani salaha ichindi.
sweeden.
1995 mae 26 natiki, swedish chemicals agency baby seesaalapai bpa nishedham vidhinchaalani korindi, ayithe swedish phud safety authority anchanaa vesina european phud safety authority yokka naveekarinchabadina sameeksha kosam vechi undataaniki ishtapadutundi. paryaavarana mantri efsa sameeksha kosam vechi undamani chepparu, conny ekkuva kaalam kaadu.
marchi 2011 nundi bisphenol eah kaligina baby bottlesnu tayaaru cheyadam nishedhinchabadindi mariyu juulai 2011 nundi vaatini dukaanaalaloo konugolu cheyalemu. 2012 april 12naa, swedish prabhutvam moodu samvatsaraala kante takkuva vayassu unna pillalaku aaharaanni kaligi unna dabbaalalo bpnu nishedhinchanunnatlu prakatinchindi.
2020 janavari 2 nundi, european union vistruta nishedham phalitamgaa, bpa thermal receiptlalo nishedhinchabadindi.
septembaru 1,2016 nundi, sipto neeti gottalanu reline chesetappudu bpnu upayoginchadam nishedhinchabadindi.
united kingdom.
2009 decemberulo, eduguru saastravettala brundam nundi vacchina lekhaku pratispandistuu, "pillalalo vikrayinche aahara samparka utpattulalo bpa vadakanni nilipivesina itara prabhutvaalu teesukunna vidhaanaaniki anugunamgaa oka drukpathaanni avalambinchaalani yuke prabhutvaanni korinappudu, yuke aahara pramaanaala samstha, 2009 janavarilo," aahara samparka padaarthaalatho sahaa anni vanarula nundi bpaku UK viniyogadaarulanu bahirgatam cheyadam haanikaramaina sthaayi kante chaalaa takkuvagaa undani "thana abhiprayanni punarudghaatinchindi.
turkey.
10 juun 2011 natiki, turkey baby seesaalu mariyu pillala kosam utpatti cheyabadina itara computer vastuvulalo bpa vadakanni nishedhinchindi.
japan.
1998 mariyu 2003 madhya, canning parisrama swachchandamgaa daani bpa kaligina epoxy resin canlanu bpa-rahita polyethylene terephthalate (pempudu jantuvu) thoo bharti chesindi. itara utpattula kosam, idhi vaerae epoxy liningku maarindi, idhi gatamlo upayoginchina resin kante aahaaramloki bpa yokka chaalaa takkuva olasalanu istundi. adanamgaa, paatasaala bhojanaala kosam paalii carbonate tableware sthaanamlo bpa-rahita plaastiklu bharti cheyabaddaayi.
maanava bahirgata muulaalu.
kalushitamaina aaharam mariyu neetini teesukovadam sahaa aaharam bpaku pradhana maanava bahirgata maargam.
kathinamaina detergentlatho subhram chesinappudu ledhaa vaatilo aamla ledhaa adhika-ushnograta dravaalanu kaligi unnappudu plaastik nundi idhi mukhyamgaa bayataku vachhe avakaasam undhi. neeti gottala epoxy resin puutanu roopondinchadaaniki bpa upayoginchabadutundi; paatha bhavanaalalo, ksheenistunna gottala bharteeni nivaarinchadaaniki ituvanti resin puutalu upayoginchabadataayi. pani pradaesamloe, bpa kaligi unna utpattulanu nirvahinchadam mariyu tayaaru cheyadam, peelchadam mariyu charma bahirgatam cheyadam atyanta sambhaavya margalu. digital media, electrical mariyu electronic parikaraalu, automobiles, creeda bhadrata parikaraalu, printed circuit bordula kosam electrical laminetlu, misramaalu, paintlu mariyu antukune padaarthaalatho sahaa sambandhita sambhaavya exposurelanu puurtigaa anchanaa veyani bpa yokka aneka upayogaalu unnaayi. prajalu rojuvaareegaa upayoginche aneka utpattulalo undatame kakunda, bpaku mukhyamgaa neeti vanarulalo bioacumulate chese saamarthyam undhi. oka sameekshalo, bpa jeevaadhokaranam chendedi ayinappatikee, aneka jalamargalalo muruguneeti suddhi tarvaata sumaru 1 yuji/ell saandratalatoe idhi ippatikee kanugonabadindani kanugonabadindi. eee adhyayanam bpa sambhaavyamgaa bioacumulate cheyagala itara maargaalanu kooda pariseelinchindi mariyu "takkuva-madhyastha saamarthyaanni" kanugondi...suukshmajeevulu, algay, akasherukaalu mariyu paryaavaranamloo chepalu "konni paryaavarana bahirgatamayye avakaasam takkuvagaa undani suuchistunnaayi.
2009 navambarulo, "viniyogadaarula nivedikalu" patrika konni tayaarugaa unna aaharaalu mariyu paneeyalalo bpa content yokka vislaeshanhanu prachurinchindi, ikkada nirdishta sandarbhaallo oka dabbaalo unna aaharam yokka content fda "sanchita bahirgatam rojuvaaree teesukovadam" parimitini minchipovachhu.
1988-1994 loe namoonaga teesukunna 95 saatam mandhi peddala moothramlo bisphenol eah nuu CDC kanugondi mariyu 2003-04 loe pareekshinchina 93 saatam mandhi pillalu mariyu peddalalo kanugonnaru. bpa kosam yousafa reference motaadu (rfd) 50 microgram/kejee/roeju, idhi amalu cheyalenidi conny surakshitamaina bahirgata sthaayi sifaarsu cheyabadindi. atyanta sunnitamaina janthu adhyayanalu chaalaa takkuva motaadulo prabhavalanu chuuputaayi, mariyu atyadhika sthaayilanu kaligi unna pillala yokka aneka adhyayanalu, epa suuchimchina surakshita parimiti sankhya kante sthaayilanu kanugonnayi.
2009loe kenadaalo jarigina oka aarogya adhyayanamlo, adhi pareekshinchina tayaarugaa unna sheetala paneeyalalo ekkuva bhaagam takkuva, conny kolavagala bisphenol eah sthaayilu unnayani kanugonnaru. 2010loe texas vishwavidyaalayam school off public health nirvahinchina oka adhyayanamlo plaastik packaging mariyu tayaarugaa unna shishu formulalo vikrayinche taja turkeytho sahaa taja mariyu tayaarugaa unna aaharaala 105 namoonaalalo 63 namoonaalalo bpa kanugonabadindi. paryaavarana aarogya drukpathaalu" loe prachurinchabadina 2011 adhyayanam, "aahara packaging mariyu bisphenol eah mariyu bis (2-ethyhexyl) thalet exposure aahara jokyam nundi kanugonnavi", bpa adhyayanam cheyadaaniki tayaarugaa unna mariyu pyaak chesina aaharaala sweeya-nivedinchina upayogam aadhaaramgaa 20 mandhi paalgonevaarini empika chesindi. paalgonevaaru vaari saadhaarana aaharaanni tinnaru, taruvaata moodu rojula paatu tayaarugaa ledhaa pyaak cheyani aaharaanni tinnaru. adhyayanam yokka phalitaalalo ivi unnaih 1) taja aaharaalu tine samayamlo palgonevari moothramlo bpa yokka aadharalu 50 saatam nundi 70 saatam varaku taggai; mariyu 2) vaari aahara paddhatula gurinchi palgonevari nivedikalu tayaarugaa unna aaharaalu mariyu paaneeyaalu mariyu restaurant bhojanaala viniyogam vaari saadhaarana aaharalalo bpaku gurayye avakaasam undani suuchimchaayi. eee 20 mandhi paalgonevaariki minchi, bpa bahirgatam vistrutamgaa undani, moothra namoonaalalo gurtinchadagina sthaayilu 90 saatam kante ekkuva yoolo unnayani parisoedhakulu gamaninchaaru.ess. janabha. maroka yuu.ess. soda viniyogam, paatasaala bhojanam mariyu inti velupala tayaaruchesina bhojanam ganankaparamga adhika moothra bpatho gananeeyamgaa mudipadi unnayani adhyayanam kanugondi.
haarvard school off public healthloni parisoedhakulu 2011loe chesina oka prayogam aahara dabbala poralo upayoginche bpa aaharam dwara grahinchabadutundani, aapai viniyogadaarulu teesukuntaarani suuchimchimdi. 75 mandhi paalgonevaarilo, sagam mandhi aidu rojula paatu tayaarugaa unna kuuragaayala suup bhojanam tinnaru, taruvaata aidu rojula taja suup, migilina sagam mandhi adhe prayogaanni vyatiraeka kramamlo chesaaru. "vislaeshanhaloo paalgonevaaru tayaarugaa unna suup tinetappudu, vaaru taja suup meeda bhojanam chesinappudu poliste vaari moothra saandrata bpalo 1,000 saatam kante ekkuva perugudalanu anubhavinchaarani velladaindi."
2009loe jarigina oka adhyayanamlo polycarbonate seesaala nundi taagadam valla muutramlooni bisphenol sthaayilu moodinta rendu vantula varaku perigaayani, 1.2 microgram/gram creatinine nundi 2 microgram/gram creatininku perigindani kanugonnaru. plaastik bisphenol rahitamgaa undani packaging suuchisthee tappa, bisphenol bahirgatam tagginchukovalanukune vyaktulu tayaarugaa unna aaharam mariyu paalii carbonate plaastik kantainarlanu (idhi aneka itara plaastiklatoe resin gurtimpu code 7nii panchukuntundi) nivaarinchaalani viniyogadaarula samuuhaalu sifaarsu chestunnayi. aaharam ledhaa paaneeyaalaloki bpa leaching ayye avakaasaanni nivaarinchadaaniki, national toxicology panel plaastik containerlalo microwave aaharaanni nivaarinchaalani, dishwasherlo plaastiknu unchaalani ledhaa kathinamaina detergentlanu upayoginchavaddani sifaarsu chestundi.
aahaaramto paatu, gaali dwara mariyu charmam shoshana dwara kooda bahirgatam kaavacchu. uchita bpa anedi thermal paper mariyu carbon rahita coppy paperlo adhika saandrataloo kanipistundi, idhi bpa kante resin ledhaa plaastiktoe bandhinchabadina exposureku ekkuvagaa andubaatulo untundani bhaavistunnaaru. thermal paper yokka prajaadarana pondina upayogaalalo raseedulu, eevent mariyu cinema tikketlu, labels mariyu vimanayana tikketlu unnaayi. 13 thermal printing paperlalo 11 paperlalo (bpa) unnayani oka swiss adhyayanam kanugondi. thermal paper raseedutho podi vaelini taakinappudu, sumaruga bpa () nuu nuditi vaelu mariyu madhya vaeliki badilee chesaaru. tadi ledhaa jiddugala vella kosam daadaapu ekkuva badilee cheyabadindi. vella nundi bpa velikiteeta bahirgatam ayina taruvaata varaku saadhyame. inca, 24 gantala paatu parsulo kaagitapu currencytho taakina ushna raseedulu kaagitapu currencylo bpa gaadatalo naatakeeya perugudalaku kaaranamavutaayani, kaagitapu dabbunu bahirgatam cheyadaaniki rendava vanarugaa maarustaayani niroopinchabadindi. vislaeshimchina anni vyardha kaagitam namoonaalalo (vaartaapatrikalu, patrikalu, karyalaya kaagitam modalainavi) bpnu maroka adhyayanam gurtinchindi.), kaagitam recycling dwara kalushyam yokka pratyaksha phalitaalanu suuchistumdi. uchita bpnu charmaniki takshaname badilee cheyavachu, mariyu chetulapai avasheshaalanu teesukovachhu. charma shoshana dwara saareeraka viniyogam (veetilo 99 saatam raseedula nirvahana nundi vastundi) saadhaarana janaabhaaku 0.219 ng/kilograamula bw/roeju (vruttiparamgaa bahirgatamaina vyaktulu 16.3 ng/kilograamula bw/roeju vadda adhika mottaanni grahistaaru) anie choopabadindi, ayithe peddalaku mottam teesukovadam (aaharam/paaneeyam/paryaavaranam) 0.36-0.43 μg/kilograamula bw/roeju (vruttiparamgaa bahirgatamaina peddalaku anchanaa vesina teesukovadam 0.043-100 microgram/kilograamula bw/roeju) gaa anchanaa veyabadindi.
2011 nundi jarigina oka adhyayanamlo anni vayasula americanla sareeramlo kenadiyanla kante rendu retlu ekkuva bpa undani kanugonnaru; asamaanatalaku kaaranaalu teliyavu, endukante uslo bpa adhika mottamlo undani suuchimchadaaniki etuvanti aadharalu laevu.ess. aaharaalu ledhaa uslo andubaatulo unna viniyogadaaru utpattulu.ess. kenadaalo bpa kaligi unnavi bpa rahitamgaa undevi. maroka adhyayanam prakaram, sarvelu elaa, eppudu jarigaayi anedaanilo thedaalu undavacchu, endukante "janabhalo kolichina saandratala poolikalu cheyagaliginappatiki, namoonaalo, upayoginchina vislaeshanhaatmaka paddhatulalo mariyu vislaeshanhala sunnitatvamlo vyatyaasaala kaaranamgaa idhi jagrattagaa cheyali."
2003 mariyu 2012 madhya naalugu kaala vyavadhula nundi jaateeya aarogya mariyu poeshakaahaara pareeksha sarvela (enn. enn. yea. enn) nundi daetaanu polchinappudu, moothra bpa dayta mottam janaabhaaku sagatu rojuvaaree teesukovadam sumaru 25 ng/kilolu/roeju mariyu prastuta aarogya aadhaarita maargadarsakaala kante takkuvagaa undhi. adanamgaa, united stateslo bpa rojuvaaree teesukovadam 2003-2004 loe kolichina motaadutoe poliste gananeeyamgaa taggindi. eee kaalamlo prajala drushti mariyu prabhutva charya bpa bahirgatam kontavaraku tagginchi undavacchu, conny eee adhyayanaalalo aaru samvatsaraala kante takkuva vayassu unna pillalu cherchabadaledu. endocrine society prakaram, endocrine antaraayam kaliginche rasayanalu enthavaraku prabhavam chuputayo nirnayinchadamlo bahirgatam ayye vayassu oka mukhyamaina amsam, mariyu pindam ledhaa sisuvulanu abhivruddhi cheyadampai prabhavalu peddavaari kante chaalaa bhinnamgaa untaayi.
pindam mariyu prarambha baalya bahirgatam.
2009 adhyayanam saadhaarana bahirgata paristhitulalo peddala kante chinna pillalalo moothra saandratalu ekkuvagaa unnayani kanugondi. peddavaarilo, kaaleyamlo nirvisheekarana prakriya dwara bpa sareeram nundi tolaginchabadutundi. sisuvulu mariyu pillalalo, eee maargam puurtigaa abhivruddhi chendaledu kabatti vaaru tama vyavasthala nundi bpnu tolaginche saamarthyam taggutundi. pillalapai iteevala jarigina aneka adhyayanalu suuchimchina surakshita parimiti sankhyanu minchina sthaayilanu kanugonnayi.
drava suutramtoe tinipinche sisuvulu atyanta bahirgatam cheyabadataru, mariyu paalii carbonate seesaala nundi tinipinche suutram rojuku shareera baruvulo kiloku 13 microgramula bisphenol varaku viniyoginchavacchu (microgram/kilolu/roeju; krinda pattikanu chudandi). yuu loe.ess. mariyu kenada, bpa shishu drava suutramloe 0.08 nundi 11 ng/g varaku maarutuu untundi. bpa sisuvu podi suutramloe arudugaa kanipistundi (14 loe 1 matrame). yuu.ess. aarogya mariyu maanava sevala vibhagam (hetchhets) "shishu formula mariyu aaharam nundi manchi poeshakaahaaram yokka sthiramaina muulam yokka prayojanam bpa bahirgatam ayye pramaadaanni adhigamistundi" anie perkondi. maanava rommu paalalo bpa untundi, rommu paala namuunaala 62-75% loe aneka adhyayanalu kanugonnayi. idhi sareeram dwara sahajamgaa utpatti kaananduna tallulu bpaku gurikavadam dheeniki kaaranam kaavacchu.
peddalu kante pillalu bpa exposureku ekkuvagaa gurayye avakaasam undhi (aarogya prabhavalanu chudandi). 
austria, switzerland mariyu germanyloni prajalapai 2010loe jaripina oka adhyayanam sisuvulaku paalii carbonate (pisi) baby seesaalu bahirgatam kaavadamlo atyanta pramukha paatra poeshistaayani, peddalu mariyu yuktavayaskulaku tayaarugaa unna aaharaanni suuchimchimdi. united stateslo, iteevali samvatsaraalalo sisuvulalo bpa exposurepy perugutunna aandolana plaastik baby seesaala tayaareedaarulu tama seesaalalo bpnu upayoginchadam maaneyadaaniki daariteesindi. baby seesaalu mariyu sippy kappulalo (juulai 2012) bpa vadakanni, alaage shishu formula packaginglo epoxy resinla vadakanni fda nishedhinchindi. ayithe, companylu bpnu upayoginchadam manese mundu konugolu chesina paatha ledhaa naaku-chethitho-kindaku teese seesaalanu pillalaku tinipiste, pillalu inca bahirgatam kaavacchu.
garbhinii stree bahirgatam ayinappudu tarachugaa nirlakshyam cheyabadina bahirgatam yokka muulam sambhavistundi, tadwara pindam bahirgatamavutundi. garbhinii elukala maavi mariyu amneotic dravam rendintiloonuu bpa kanugonabadutundani janthu adhyayanalu choopinchaayi. garbhinii streela moothram mariyu seeram mariyu navjata sisuvula seeram, plasma mariyu maavilo kooda bpa kanugonabadinanduna, bpaku prasavapurva bahirgatamto sambandham unna bahya pravartanalanu pariseelinchadaaniki oka adhyayanam nirvahinchabadindi, idhi abhivruddhilo mundu bahirgatam pravartana phalitaalapai ekkuva prabhavanni chooputundani mariyu aada pillalu (2 samvatsaraala vayassu) purushula kante ekkuvagaa prabhaavitamavutaarani suuchistumdi. 244 mandhi tallulapai jaripina oka adhyayanamlo, puttina mundu bpaku gurikavadam 3 samvatsaraala vayassulo unna baalikala pravartananu prabhaavitam chestundani suuchimchimdi. garbhadhaarana samayamlo talli moothramlo bpa adhika sthaayilo unna baalikala aandolana mariyu hyperactivity pareekshalalo marinta adhvaannamgaa score chesindi. eee ammayilu ippatikee saadhaarana paridhiloonae score chesinappatiki, talli bpalo prati 10 retlu perugudalaku, ammayilu pareekshalalo kaneesam aaru paayintlu takkuvagaa score chesaaru. garbhadhaarana samayamlo abbayilu tama talli bpa sthaayilatho prabhaavitam kaaledani telustondi. sisuvu janminchina tarvaata, talli paalu dwara sisuvuku bpa badilee cheyadam dwara talli bahirgatam sisuvunu prabhaavitam chestune untundi. garbhadhaarana samayamlo mariyu taruvaata sambhavinche eee exposures kaaranamgaa, tama bidda bpaku gurikavadanni parimitam cheyalanukune tallulu aaa samayamlo tama sonta exposurelanu parimitam cheyadaaniki prayatninchaali.
ekkuva exposurelu aaharam dwara vastaayani chuupabadinappatikii, pramaadavasaattu teesukovadam kooda exposureku muulamgaa pariganinchavacchu. japaanlo nirvahinchina oka adhyayanamlo plaastik baby pustakaalanu pareekshinchi, pillalu vaatini namilinappudu laalaajalamloki karagala avakaasam undani kanugonnaru. eee adhyayanam yokka phalitaalu inca pratiroopam kaanappatikee, konni pustakaalu ledhaa bommalanu namaladam dwara sisuvulalo kooda bahirgatam avtunda anie prashninchadaaniki idhi kaaranam istundi.
niyantrana.
united stateslo prajaarogya niyantrana charitra.
charless schumer 2008 naati 'bpa-free kids act' nuu usku pravesapettaadu.ess. pillala upayogam kosam roopondinchina edainaa utpattilo bpnu nishedhinchaalani koorutuu senate korutondi mariyu bpa bahirgatam yokka aarogya prabhaavaala gurinchi adhyayanam nirvahinchadaaniki vyaadhi niyantrana kendram avasaram. idhi 2009loe senate mariyu house rendintiloonuu tirigi pravesapettabadindi, conny pratisaaree kamiteelo maraninchindi.
2008loe, prastuta parimitulu surakshitamainavani eff. dii. yea. viniyogadaarulaku bharosa ichindi, conny eee samasyanu sameekshinchadaaniki bayati nipunula brundaanni samavesaparichindi. long adhyayanam vidudala cheyabadindi, mariyu saha rachayita david melzer adhyayanam yokka phalitaalanu fda panel mundu samarpinchaaru. long studdy prachuranatho kuudina oka sampaadakeeyamlo bisphenol eah gurinchi fda anchanaa veyadaanni vimarsinchaaruh "oka praathamika samasya emitante bpa kosam prastuta aadhi [aamodayogyamaina rojuvaaree teesukovadam] 1980la praarambhamlo paatha paddhatulanu upayoginchi nirvahinchina prayogaalapai aadharapadi undhi (chaalaa ekkuva motaadulu matrame pareekshinchabaddaayi) mariyu sunnitamaina vislaeshanhalu. swatantra saastravettala nundi iteevali parisoedhanalanu fda tiraskarinchindi, endukante aaa parisoedhakulu paryaavarana rasaayanaala kosam paatha pariksha maargadarsakaalanu anusarinchaledu, ayithe paatha, sunnitatvam laeni madimpulanu (pradhanamgaa rasayana parisrama dwara nidhulu samakuurchabadina adhyayanaalatho kuudina) upayoginche adhyayanalu prastuta bahirgata sthaayilalo bpa hanikaram kaadani nirdhaaranaku raavadamlo ekkuva praamukhyata istayi."vandalaadi itara adhyayanala phalitaalanu takkuvagaa chuuputuu, rendu adhyayanala aadhaaramgaa thana teermaanaanni istunnamani fda vimarsinchindi."mahilalu mariyu kutumbaala jaateeya parisoedhanaa kendram adhyakshuralu diana jakkarman, aahara samparka anuvartanaallo upayogam kosam bisphenol eah yokka musaida anchanaapai fda bahiranga samavesamlo thana saakshyamlo fdnu vimarsinchaaru," "kaneesam, fdaku bpatho tayaaru chesina utpattulapai pramukha heccharika avasaram".
marchi 2009loe newyorkloni safolk county bisphenol eah thoo tayaaru chesina baby paaneeyaala kantainarlanu nishedhinche chattanni aamodinchina modati kounteegaa nilichindi. marchi 2009 natiki, house mariyu senate rendintiloonuu bisphenol eah nii nishedhinche chattam pratipaadinchabadindi.
adhe nelaloo, augustu 2008loe bpa bhadratanu nokki cheppadaniki fda upayoginchina rendu adhyayanala rachayita ayina rochelle tyle, aaa adhyayanalu bpa surakshitamani cheppaledani, endukante avi rasayana prabhaavaala yokka anni amsaalanu cover cheyadaaniki roopondinchabadaledani chepparu. mae 2009loe, minnesota mariyu chikago modati yuu.ess. bpnu parimitam chese ledhaa nishedhinche nibandhanalanu aamodinche adhikara paridhi. 2009 juunloo, fda bpa bhadrata sthaayilanu punahpariseelinchaalanna thana nirnayaanni prakatinchindi. attadugu sthaayi raajakeeya charya connecticut modati yuga maaradaaniki daariteesindi.ess. shishu formula mariyu baby phud containerla nundi matrame kakunda, edainaa punarviniyogaparachadagina aaharam ledhaa paaneeyaala container nundi kooda bisfenaalnu nishedhinchaalani rashtram perkondi. 2009 joolailo, california paryaavarana parirakshana samstha yokka abhivruddhi mariyu punarutpatti vishapuurita gurtimpu kamitee california office off environmental health hazard assessment loe punarutpatti haani kaligistundani nammutunna rashtra rasaayanaala jaabitaalo bisfenaalnu unchadaaniki vyatiraekamgaa ekagreevamgaa ootu vesindi. jantuvulalo bpa yokka punarutpatti haanini choopinche perugutunna shaastreeya aadhaaraalapai panel aandolana chendindi, maanavulalo prabhaavaala gurinchi taginanta dayta ledani kanugondi. adhe panel 2006 varaku eee jaabitaaku second hanned poganu jodinchadamlo viphalamaindani, gatha moodu samvatsaraalalo eee jaabitaaku oke oka rasayananni matrame jodinchinatlu vimarsakulu etthi chuupaaru. september loe, yuu.ess. kaaryaacharana pranaalika abhivruddhi kosam bpnu moolyaankanam chestunnatlu paryaavarana parirakshana samstha prakatinchindi. octoberlo, bpa yokka aarogya prabhavalanu adhyayanam cheyadaaniki nih $30,000,000 uddeepana nidhulanu prakatinchindi. eee dabbu aneka peer-reviewed prachuranalaku daariteeyaalsi undhi.
2010 janavari 15naa, pindam, sisuvulu mariyu chinna pillalalo medadu, pravartana mariyu prostate grandhi meeda bpa yokka sambhaavya prabhaavaala gurinchi fda "kontha aandolana" vyaktam chesindi, mariyu aahara sarafaraalo bpaku maanava bahirgatam tagginchadaaniki sahetukamaina charyalu teesukuntondani prakatinchindi. ayithe, fda kutumbaalu shishu formula ledhaa aaharaala vadakanni maarchaalani sifaarasu cheyaledu, endukante manchi poeshakaahaaram yokka sthiramaina muulam yokka prayojanam bpa bahirgatam nundi vachhe pramaadaanni adhigamistundani idhi chusindi. adhe teedeena, aarogya mariyu maanava sevala vibhagam pillala bpa exposurenu tagginchadamlo tallidandrulaku sahaayapadataaniki samacharanni vidudala chesindi. 2010 natiki chaalaa mandhi yuu.ess. rashtraalu oka vidhamaina bpa nishedhaanni pariseelistunnaayi.
juun 2010loe president yokka cancer panel yokka vaarshika nivedika 2008-2009 vidudala cheyabadindi mariyu sifaarsu cheyabadindihi "aneka cancerla sudeergha jaapyam kaalam kaaranamgaa, andubaatulo unna aadharalu eee vibhina rasaayanaalaku mundu jaagratta vidhanam kosam vaadistaayi, veetilo (...) bisphenol eah ". augustu 2010loe, maine board off environmental protection janavari 2012 natiki bisphenol eah thoo tayaaru chesina baby seesaalu mariyu itara punarviniyoga aahara mariyu paaneeyaala containerla ammakalanu nishedhinchadaaniki ekagreevamgaa ootu vesindi. fibravari 2011loe, maine kottagaa ennikaina governor paal lepage, sthaanika tv nyuus sholo matladutu, nishedhaanni raddu cheyaalani aasistunnatlu matladutu jaateeya drushtini aakarshincharu, endukante, "samasya undani gurtinche sains edhee ledhu" mariyu jodincharu "neenu vinna ekaika vishayam emitante, meeru plaastik bottle teesukoni microwavelo unchi, meeru daanini vaedi chesthe, adhi eastrogen maadirigaane rasayananni vidudala chestundi. kabatti chettha paristhiti emitante kontamandi mahilalaku takkuva gaddam undavacchu."2011 eprillo, maine saasanasabha baby seesaalu, sippy kappulu mariyu itara punarviniyoga aahara mariyu paaneeyaala containerlalo bpa vadakanni nishedhinche billunu aamodinchindi, idhi 1 janavari 2012 nundi amaluloki vachindi. governor lepage billupai santakam cheyadaaniki niraakarinchaaru.
october 2011loe, california baby seesaalu mariyu pasipillala taguneeti kappula nundi bpnu nishedhinchindi, idhi 1 juulai 2013 nundi amaluloki vachindi. 2011 natiki, 26 rashtraalu bpa yokka konni upayogaalanu nishedhinche chattanni pratipaadinchaayi. kamiteelo aneka billulu chanipoyayi. juulai 2011loe, american medical association (amaa) bpa kaligi unna sisuvulu mariyu sisuvulaku tine utpattulanu nishedhinchaalani prakatinchindi. idhi bpa yokka merugaina samakhya paryaveekshanha mariyu daanini kaligi unna utpattula spashtamaina labelingnu sifaarsu chesindi. aahara mariyu paaneeyaala bpa-kaligina utpattula niyantranalo prastuta saastraanni churukuga cherchadam fda yokka praamukhyatanu idhi nokki cheppindi."
2012loe, fda bpa prabhavalapai shaastreeya parisoedhana yokka anchanaanu muginchindi mariyu marchi 2012 viniyogadaarula naveekaranalo "eee samayamlo shaastreeya aadharalu aaharam dwara bpaku maanava bahirgatam chaalaa takkuva sthaayilu surakshitam kaadani suuchimchavu" anie perkondi, ayithe "adhyayanaalalo upayoginchina bahirgatam yokka maargam mariyu maanava aarogyaaniki janthu namuunaala auchityam sahaa eee adhyayanala mottam vivaranalo sambhaavya anischitulanu gurtinchindi. eee anischitulanu parishkarinchadaaniki eff. dii. eah. adanapu parisoedhananu konasagistondi."inca 2012 juulai 17naa, fda baby seesaalu, sippy kappula nundi bpnu nishedhinchindi. agency charya bhadrata aandolanalapai aadharapadi ledani, "aaharaanni kaligi unna utpattulalo upayogam kosam bpa bhadrataku agency maddatu istundani fda pratinidhi telipaaru."tayaareedaarulu ippatike baby seesaalu mariyu sippy kappulalo rasayananni upayoginchadam maanesinanduna, eee nirnayam american chemistry council, rasayana parisrama yokka pradhana vaanijya sangham abhyardhanaku pratispandanagaa, nishedham viniyogadaarula vishwaasaanni penchutundani nammadu. eee nishedhaanni paryaavarana working group "puurtigaa soundarya" gaa vimarsinchindi, idhi "vividha rakaala teevramaina mariyu deerghakaalika paristhitulaku sambandhinchina eee vishapuurita rasaayanaaniki prajalu gurikakunda agency nijamgaa nirodhinchaalanukunte, adhi shishu formula, aaharam mariyu paaneeyaala dabbaalalo daani vadakanni nishedhinchaali."sahaja vanarula rakshana mandali eee charya saripodani, fda anni aahara packaging nundi bpnu nishedhinchaalsina avasaram undani perkondi.
2014 natiki, 12 rashtraalu pillala seesaalu mariyu feeding containerla nundi bpnu nishedhinchaayi.
united stateslo paryaavarana niyantrana.
2009 december 30naa epa bpatho sahaa naalugu rasaayanaala kosam kaaryaacharana pranaalikanu vidudala chesindi, idhi visha padaarthaala niyantrana chattam kinda niyantrinchabade "aandolana kaliginche rasaayanaala" jaabitaalo cherchabadi undedi. 2010 fibravarilo, rasayana parisramaku chendina lobbyistlu paripalana adhikaarulanu kalisina taruvaata, epa rasayananni cherchakapovadam dwara bpa niyantrananu alasyam chesindi.
29 marchi 2010naa, epa bpa kosam savarinchina kaaryaacharana pranaalikanu "aandolana kaliginche rasayana" gaa prachurinchindi. 2010 octoberulo bpa pareeksha kosam pratipaadita niyamaala tayaareeki sambandhinchina mundastu notice juulai 2011loe federal registerlo prachurinchabadindi. nirvahana mariyu budget (ombi) karyalayamlo bhaagamaina samachara mariyu niyantrana vyavahaaraala (oira) karyalayamlo 3 samvatsaraalaku paiga panichesina taruvaata, 3 nelallopu musaida pratipaadanalanu sameekshinchaalsi untundi, oira alaa cheyaledu.
2013 septembarulo epa thana 2010 musaida bpa niyamanni upasamharinchukundi. eee niyamam "ikapai avasaram ledhu" anie chepparu, endukante epa rasayanalanu chudatamlo vaerae marganni teesukuntondi, pramaada anchanaa mariyu pramaada taggimpu kosam 80 kante ekkuva rasaayanaala "work plaan" anie pilavabadedi. epa upasamharinchukunna maroe pratipaadita niyamam, sameeksha kosam tsca kinda kotta rasayanalanu samarpinchinappudu, avasaramaina aarogya mariyu bhadrata adhyayanala kosam parisrama yokka gopya vyapara samacharam (cbi) yokka parimita daavaalanu kaligi untundi. gopyata yokka anavasaramaina vaadanalanu tagginchadaaniki prayatnistuunae unnamani mariyu naatakeeya phalitaalanu pondina aneka mukhyamaina charyalu teesukunnaanani epa telipindi... sii. bii. ii. claimla kosam vidhaanaalanu kathinataram cheyadam mariyu anavasaramaina gopyata claimlanu bahirgatam cheyadam, ippatike unna sii. bii. ii. claimlu ippatikee chellubaatu ayyela chuudataaniki vaatini sameekshinchamani companylanu savaalu cheyadam mariyu vistruta shreni samaachaaraaniki sulabhamaina mariyu merugaina praapyatanu andinchadam."
rasayana parisrama samuuham american chemistry council "desham yokka praadhamika rasayana nirvahana chattam yokka paniteerunu balopetam chese charyanu enchukunnanduku epnu prasamsimchimdi."paryaavarana rakshana nidhi senior shaastravetta richard denison," "rendu niyamaalu rasayana parisrama nundi teevramaina vyatiraekata mariyu lobbying kuu lobadi unnaayi" "anie vyakhyaaninchaadu mariyu" "[samachara mariyu niyantrana vyavahaaraala karyalayam] epnu ennadoo anumatinchadani anae vaastavaanni bahusha edurkondi"."
29 janavari 2014naa epa paryaavarana karyakramam kosam daani roopakalpanalo bhaagamgaa thermal paperlo bpa kosam tudi pratyaamnaaya anchanaanu vidudala chesindi.
rasayana tayaareedaarulu nishedhaalaku pratispandistaaru.
marchi 2009loe aaru atipedda yuu.ess. baby seesaala utpattidaarulu tama utpattulalo bisphenol eah nuu upayoginchadam maaneyaalani nirnayinchukunnaaru. adhe nelaloo gasoline mariyu rasaayanaala utpattidaaru ayina sanoko, 3 samvatsaraala kante takkuva vayassu unna pillala kosam aaharam mariyu neeti containerlalo upayoginchadaaniki companylaku bpa vikrayinchadaaniki niraakarinchindi, sammelanam yokka bhadrata gurinchi khachitamgaa cheppalemani cheppindi.
2009 maeloe, washington postku chendina lindsay layton aahara mariyu paaneeyaala containerla tayaareedaarulu mariyu vaari atipedda viniyogadaarulalo kondaru praja sambandhaalu mariyu prabhutva bpa nishedhaalanu nirodhinchadaaniki lobbying vyuuham gurinchi aaropinchaaru. prabhutva saastravettalu mariyu vishwavidyaalaya prayogasaalalu rasaayanaala gurinchi aarogya samasyalanu levanettina 100 kii paiga prachurinchina adhyayanalu unnappatikee, aahara mariyu aushadha paripalana pradhanamgaa rendu adhyayanala kaaranamgaa surakshitamgaa bhaavinchindi, rendintikee rasayana parisrama vaanijya samuuham nidhulu samakuurustumdi" anie aame paerkonnaaru. augustu 2009loe bpa mariyu daani prabhavalapai "milwaukey journal sentinel" parisoedhanaatmaka syries bpa mariyu daani prabhavalapai pratikuulamgaa nivedinche ledhaa vyaakhyaaninchae vaaripai daadi chesi, apakeerti chendhe pranaalikalatoe sahaa bpnu prothsahinchadaaniki plaastik parisrama yokka pradhana praja sambandhaala pranaalikalu samaajaaniki choopinchaayi.
bpa uchita, teliyani pratyaamnaayam.
kalakramena rasayana parisrama "bpa-rahita" utpattulanu prothsahinchadam dwara bpa vimarsalaku pratispandinchindi. udaaharanaku, 2010loe, saadhaarana millulu tamotalatho panichese "bpa-free pratyaamnaaya" canlinernu kanugonnatlu prakatinchaayi. aaa samvatsaram tamota pantatho paatu daani sendriya aaharaala anubandha samstha muir glen vikrayinche tamota utpattulalo bpa-rahita pratyaamnaayaanni upayoginchadam praarambhistaamani telipindi. 2014 natiki, saadhaarana millulu yea pratyaamnaaya rasayananni upayogistunnayo, daani itara tayaarugaa unna utpattulapai upayogistunnayo ledho cheppadaniki niraakarinchaayi.
bpa free, epoxy free.
minority companylu taamu yea pratyaamnaaya sammelanam (lanu) upayogistunnam anie perkonnaayi. pratinidhi edward markey (dii-maas) vichaarana taruvaata padihedu companylu camp bell suup company mariyu general mills ink thoo sahaa bpa-freega veltunnaayani samadhanam icchaayi. taamu bisphenol esnu upayogistunnamani ledhaa upayoginchabotunnatlu yea company cheppaledu; kevalam naalugu companylu matrame taamu upayoginchaboye bpaku pratyaamnaayaanni perkonnaayi. 2013loe konagra "tamotalaku pratyaamnaaya linerlu vinail" anie perkondi...kotta aerosol dabbaalu polyester resinto kappabadi untaayi. eden aaharaalu tama beans matrame endocrine distruptor bpa laeni olerosinus sii-enamel linertho tayaarugaa unchabadathaayani perkonnaayi. olerosine anedi paine ledhaa balsum phir vanti mokkala nundi sekarinchina noone mariyu resin misramam. haine khagola samuuham savarinchina polyester mariyu/ledhaa acrylicnu upayogistundi... juun 2014 natiki maa tayaarugaa unna suuplu, beans mariyu kuuragaayala kosam ". heinz 2011loe "mana aahara kantainarlannintilo epoxy lininglanu bharti cheyalanukuntunnamu" anie perkondi.... memu pillala aahaaraalaku praadhaanyata icchaamu, "mariyu 2012 loe" memu upayoginche yea plaastik containerlalo bpa ledhu ".
bpa pratyaamnaaya bps.
konni "bpa rahita" plaastiklu bisphenol ess (bps) anae sammelanaanni kaligi unna epoxy nundi tayaaru cheyabadataayi. bps bpatho samaanamaina nirmaanam mariyu bahumukha pragnanu panchukuntundi mariyu currency nundi thermal raseedu kaagitam varaku aneka utpattullo upayoginchabadindi. yuu loe teesukunna moothra namuunaala vislaeshanhaloo bps kuu vistrutamgaa maanava bahirgatam nirdhaarinchabadindi.ess.japan, chaina mariyu aidu itara asea deshaalu. parisoedhakulu pareekshinchina mottam raseedu kaagitamlo bps, kaagitapu currencylo 87 saatam mariyu recycle chesina kaagitamlo 52 saatam kanugonnaru. prajalu tama charmam dwara 19 retlu ekkuva bpsnu grahistunnarani, bpnu marinta vistrutamgaa upayoginchinappudu vaaru grahinchina daanikante ekkuvagaa grahistunnarani adhyayanam kanugondi.
2011 adhyayanamlo parisoedhakulu 455 saadhaarana plaastik utpattulanu pariseelinchaaru mariyu 70 saatam mandhi eestrogenik charyaku positivga pareekshinchaarani kanugonnaru. utpattulanu kadigina tarvaata ledhaa microwave chesina tarvaata nishpatti 95 saataaniki perigindi. adhyayanam ilaa muginchindih "memu namoonaga teesukunna daadaapu anni vaanijyaparamgaa labhinche plaastik utpattulu, resin, utpatti ledhaa retail muulam nundi swatantramgaa, vishwasaneeyamgaa gurtinchadagina eeae [endocrine activity] kaligi unna leached chemicals, bpa-freega pracharam cheyabadina vaatitho sahaa. konni sandarbhaallo, bpa-rahita utpattulu bpa-kaligina utpattula kante ekkuva ea kaligi unna rasayanalanu vidudala chestaayi."2015loe prachurinchabadina oka kramabaddhamaina sameekshalo" prastuta saahityam aadhaaramgaa, bps mariyu bpf bpa vale harmonela paramgaa churukuga untaayi mariyu endocrine antaraayam kaliginche prabhavalanu kaligi untaayi "."
final aadhaarita pratyaamnaayaalu.
bpaku sambhaavya pratyaamnaayaalo, bpaku daggari sambandham unna final aadhaarita rasayanalu gurtinchabaddaayi. vistrutam kaani jaabitaalo bisphenol ii (bpe), bisphenol bii (bpb), 4-cumyelphenol (hechpipi) mariyu bisphenol eff (bpf) unnaayi, prastutam bps matrame thermal paperlo pradhana pratyamnaayamgaa upayoginchabadutondi.
bpa yokka ksheenata.
suukshmajeevula ksheenata.
sudomonas florescencelo kanipinche enjaim 4-hydroxyacetophenone monooxygenase, (4-hydroxyphenyl) ethan-1-vann, nadf, hetch + mariyu oo2lanu 4-hydroxyphenyl acetate, naad pii + mariyu hetch2oo utpatti cheyadaaniki upayogistundi.
conninghamella elegans" anae fungus bisphenol eah vanti synthetic phenolic sammelanaalanu kooda ksheeninchagaladu.
mokkala ksheenata.
"portulaca oleratia" anedi hydroponic draavanam nundi bisphenol eah nuu samarthavantamgaa tolagistundi. idhi elaa jarugutundo aspashtamgaa undhi.
photodegradation.
photo fraila punarvyavastheekarana dwara paryaavaranamloo sahaja vaataavaranaaniki photodegradation anedi bpa yokka pradhana paddhati. prayogaatmakamgaa, neeti krimisamhaaraka vidhaanaala paddhatulugaa jink oxide, titanium dioxide mariyu tinn dioxide dwara utprerakam cheyabadina praticharyalalo bpa photodegrade cheyabadindani choopabadindi. photo fries ksheenata anedi saktivantamaina ring carbon dioxidenu vidudala cheyadaaniki mundu bpa yokka sugandha carbonate vennemukanu phenyl solicilate mariyu dihydroxybenzophenono utpannaalugaa sanklishtamgaa punarvyavastheekarinchadam. jaleeya draavanamloo, bpa 250 nm mariyu 360 nm madhya tarangadairghyala yuvi shoshananu chooputundi, mariyu photo fries ksheenata 300 nm kante takkuva tarangadairghyala vadda sambhavistundi. carbonate anusandhaanamlo carbonyl carbon mariyu oxygen madhya alfa cheelika dwara praticharya praarambhamavutundi, tadupari photo fries utpattula punarvyavastheekaranatho. photo fries praticharya dwara bpa yokka photodegradation yokka vidhanam kanipistundihi
bpa dahanam.
hydroxyl radicals anevi saktivantamaina aakseekaranalu, ivi bpnu vividha rakaala phenolic samuuha sammelanaalugaa maarustaayi. sodiyam hypochlorite, naocl vanti sammelanaalanu aakseekarana agentga upayoginchi bpa yokka adhunaatana kaanti utpreraka aakseekarana, neetilo oxygennu vidudala cheyadam dwara ksheenata saamarthyaanni vegavantam chestundi. bpa yuvi vikirananku gurainappudu eee kullipovadam jarugutundi. maroka balamaina aakseekarana ayina praanavaayuvu yokka eee vidudala, carbon dioxide mariyu neetini utpatti cheyadaaniki jaleeya paristhitulalo bpa vichchinnaaniki kooda kaaranamavutundi. neetilo karigina carbon dioxide carbonic aamlam perugudalaku daariteestundi, anduvalla neeti aamleekaranaku kaaranamavutundi.
ojon dwara bpa yokka aakseekarana.
neeti suddhi samayamlo, bii. pii. eah. nii ojoneshan dwara tolaginchavacchu. 2008 adhyayanam drava varnapatam mariyu dravyarashi varnapatam yokka upayogam dwara eee praticharya yokka ksheenata utpattulanu gurtinchindi. bpa mariyu ojon yokka praticharya krinda chudavachuhu
ojoneshan prakriya puurtayina tarvaata bpa mariyu neeti draavanaalu pihech loe taggai. 6. 5 nundi 4.5 pH unitla varaku pH drops gamaninchabaddaayi. carboxylic aamlalu erpadatam valla idhi jarigi undavacchu. eee utpattulu draavanam 20 ± 2 masim unnappudu utpatti cheyabaddaayi. eee utpattulu adhika paramaanu baruvunu kaligi untaayi. alaage, ojon electrophilic, kabatti praticharyalu electrophilic pratyaamnaayam dwara ojon mariyu sugandha valayala madhya undevi.
bpa ksheenata yokka gatisastram.
1991loe, ojoneshan dwara bpa ksheenata raetu yokka modati vivarana nirnayinchabadindi.
idhi spashtamaina viyojana sthiraamkam, bpa yokka ekagrata mariyu ojon yokka ekagrata dwara bpa yokka yekagratanu kaalaaniki sambandhinchinadi.

