
immunoglobulin bhaarii sthiraamkam alfa 1

immunoglobulin bhaarii sthiraamkam alfa 1 anedi "igha 1" chihnamtho kuudina immunoglobulin janyuvu. idhi immunoglobulin yokka sthiramaina (sii) vibhaganni bhaarii golusunu suuchistumdi. immunoglobulin eah anedi shleshma poralo roganirodhaka paniteerulo keelaka paatra poeshinchae antibody. aiga itara antibody taragatula yokka adhe vilakshanhamaina nirmaanaanni chooputundi, rendu bhaarii golusulu mariyu rendu telikapati golusulu mariyu naalugu vibhina domainlu oka chara praantam mariyu moodu chara praantaalu. shareera sravalalo immunoglobulin yokka pradhana taragatigaa, sankramana nundi rakshinchadamlo, alaage roganirodhaka vyavasthaku videshee antigenla praapyatanu nirodhinchadamlo igaa paatra poeshistumdi.
aavishkarana.
igha1 mottamodata 1975loe vivaramgaa vivarinchabadindi, tryptic mariyu chemotryptic peptidela kramam dwara igaa yokka praathamika nirmaanam (amaino assid kramam) spashtam cheyabadindi. adevidhamgaa, 1979loe protein yokka alfa-2 golusu kosam praathamika kramam swatantramgaa nirnayinchabadindi. alfa-1 bhaarii golusu sthiraanka praantam mariyu allelic alfa-2 bhaarii golusu praantaala kosam puurti nucleotide kramaalu 1984loe prachurinchabaddaayi, mariyu janyuvulu moodu exanlalo unnayani choopinchaayi, veetilo prati okkati protein domine yokka oke praantaanni encode chestundi.
janyu sthaanam.
aigha1nii encoding chese janyuvulu maanava chromosome 14loe kanipistaayi. aigha1nii encoding chese kramam 1,497 nucleotidela podavu untundi mariyu idhi lokey 105,707,168 mariyu 105,708,664 madhya kanipistundi. ullekhana chromosome sthaanam kooda 14q32.33 gaa ivvabadutundi.
protein nirmaanam.
aiji alfa-1 golusu sii praantam aiji yokka sthiramaina praantaalalo modatidaanilo untundi mariyu 353 avasheshaala podavaina amaino aamlam shrenitho koodi untundi. eee praantamloo unna dviteeya nirmaanam beata tantuvulache aadhipatyam chelaayistundi, ivi naalugu samaantara beata sheetlanu nirvachistaayi. eee samaantara beata-sheetlanu sandwitch chesi rendu beata-saandvichlugaa yerparustaaru, idhi immunoglobulin madata taragati yokka vilakshanhamaina trutheeya nirmaanam. prati beata-saandvichnu kaligi unna rendu beata sheetlu oka vaipu alfa helix thoo jatacheyabadataayi. eee alfa helix eee protein kosam binding saitnu nirvachistaayi, binding sait helix yokka iruvaipula oka samaantara beata strandnu kaligi untundi. binding saitlatho paatu, beata-sandwitch yokka vyatiraeka vaipu loopla shreni dwara anusandhaaninchabadi untundi, idhi hypervariable loop vyavasthanu nirvachistundi, idhi aiga mariyu antigen madhya paraspara charya yokka pratyaekatanu nirnayinchadamlo paatranu kaligi undavacchu.
rogalakshana samacharam.
"igha1" anedi bahula myloma rekhalalo gurtinchabadina chromosome asaadhaaranataloo chikkukundi. asaadhaaranata oka sthaanaantara sanghatanagaa gurtinchabadindi, ikkada "igha1" (chromosome 14loe kanugonabadindi) mariyu "fcrl4" (chromosome 1loe kanipinche nirodhaka grahakam kosam janyu kramam encoding) madhya sthaanaantaram fusion protein utpattiki daariteestundi.

