
tirap

tirap (adaptor proteinnu kaligi unna tirr domine) anedi toll-lanty graahakaalato anubandhinchabadina adaptor anuvu. sahaja roganirodhaka vyavastha suukshmajeevula vyadhikaaraka kaarakaalanu toll-lanty graahakaala (tlrs) dwara gurtistundi, ivi vyadhikaaraka-sambandhita paramaanu namuunaalanu gurtistaayi. ververu tlrlu ververu vyadhikaaraka-sambandhita paramaanu namuunaalanu gurtistaayi mariyu anni tlrlu toll-interleukin 1 grahaka (tr) domaine kaligi untaayi, idhi signal transductionku baadhyata vahistundi. eee janyuvu dwara encode cheyabadina protein anedi roganirodhaka vyavastha yokka tlr4 signalling maargamlo palgone tirr adaptor protein. idhi nf-kappa-bii, mapk1, mapk3 mariyu jnkilanu sakriyam chestundi, dheeni phalitamgaa cytokine sraavam mariyu shotha pratispandana vastundi. eee janyuvu yokka pratyaamnaaya vibhajana aneka transcript vaeriyantlaloo phalitaalanu istundi; ayithe, anni vaeriyantlu puurtigaa vivarinchabadaledu. 

