
eah. tii. pii-sensitive potassium chaanal

eah. tii. pii-sensitive potassium chaanal (ledhaa cotp chaanal) anedi oka rakamaina potassium chaanal, idhi kanaantara nucleotidelu, eah. tii. pii mariyu eah. dii. pii. latho anusandhaaninchabadi untundi. eah. tii. pii-sensitive potassium chaanellu adanapu bhaagaalato paatu <ii. dii. 1> upabhaagaalu mariyu salphoniluria grahaka (surr) upabhaagaalato koodi untaayi. cotp chaanallu plasma poralo kanipistaayi; ayithe konni upa kana porallo kooda kanipinchavacchu. cotp chaanella yokka eee taruvaati taragatulanu sarcolemmal ("sarcotp"), mitochondrial ("mitocotp") ledhaa nuclear ("nakatp") gaa vargeekarinchavachhu.
aavishkarana mariyu nirmaanam.
cotp chaanellanu modata cardiac myocyteslo japaanlooni simoltori noma group gurtinchindi. avi insulin sraavam niyantrinche clomum loe kooda kanugonabaddayi, conny vaastavaaniki plasma porallo vistrutamgaa pampinhee cheyabadataayi. sarcotp enimidi protein upabhaagaalato (octamer) koodi untundi. veetilo naalugu lopali-diddubaatu potassium ayan chaanal kutumbam kir6.x (kir6.1 ledhaa kir6.2) kuu chendinavi, migilina naalugu salphoniluria grahakaalu (surr1, surr2eah, mariyu surr2bii). kirr upabhaagaalu rendu transmembrane spaanlanu kaligi untaayi mariyu chaanal yokka randhraanni yerparustaayi. eee upabhaagaalu moodu adanapu transmembrane domainlanu kaligi untaayi mariyu cytoplasmic vaipu rendu nucleotide-binding domainlanu kaligi untaayi. ivi potassium chaanal yokka nucleotide-madhyavartitva niyantranaku anumatistaayi mariyu jeevakriya sthithini soochinche daani paatralalo keelakam. eee upabhaagaalu sulphonylurias, mgatp (ATP yokka magnitium uppu) mariyu konni itara aushadha chaanal openarlaku kooda sunnitamgaa untaayi. anni saarkaatplu eee 4:4 nishpattilo enimidi upa unitlatho nirminchabadi undagaa, vaati khachitamaina kuurpu kanajaala rakanni batti maarutuu untundi.
mitocotp mottamodata 1991loe lopali mitochondrial pora yokka single-chaanal recordingla dwara gurtinchabadindi. mitocotp yokka paramaanu nirmaanam sarcotp kante takkuvagaa spashtamgaa ardham chesukobadindi. konni nivedikalu cardiac mitocotp kir6.1 mariyu kir6.2 upabhaagaalanu kaligi untundani suuchistunnaayi, conny surr1 ledhaa surr2 rendoo undavu. iteevala, suicinate dehydrogenase kaligi unna konni bahula protein samudaayaalu cotp chaanalla maadirigaane kaaryaacharananu andinchagalavani kanugonabadindi.
anhu pora yokka vivikta patches plasma membrane cotp chhaanals maadirigaane kinetic mariyu pharmacological lakshanaalanu kaligi unnayani kanugonadam dwara nakat yokka uniki nirdhaarinchabadindi.
kana jeevakriya yokka sensor.
janyu vyakteekarana yokka niyantrana.
naalugu janyuvulu cotp janyu kutumbaaniki chendinavigaa gurtinchabaddaayi. surr1" mariyu "kir6.2" janyuvulu chr11p15.1 loe undagaa "kir6.1" mariyu "surr2" janyuvulu chr12p12.1 loe nivasistaayi. "kir6.1" mariyu "kir6.2" janyuvulu cotp chaanal yokka randhraalanu yerparuchukune upabhaagaalanu encode chestaayi, surr upabhaagaalu "surr1" (surr1) janyuvu dwara encode cheyabadataayi ledhaa "surr2" janyuvu (surr2a mariyu surr2b) yokka empika chesina vibhajana dwara encode cheyabadataayi.
eee janyuvula pratilekhanamlo maarpulu, tadwara cotp chaanalla utpatti, jeevakriya vaataavaranamloo maarpulatoe neerugaa mudipadi untaayi. udaaharanaku, adhika glucose sthaayilu, "kir6.2" mrna sthaayilo gananeeyamaina taggudalanu prerepistaayi-eee prabhavanni takkuva glucose gaadata dwara tippikottavachu. adevidhamgaa, 60 nimishala ischemia taruvaata 24 nundi 72 gantala reperfusion edama jatarika eluka mayosaitlalo "kir6.2" transcription perugudalaku daariteestundi.
hypoxia mariyu ischemiaku kanam yokka cotp praticharya kosam oka yantraangam pratipaadinchabadindi. takkuva kanaantara praanavaayuvu sthaayilu mitochondrialo tii. sii. eah. chakranni mandaginchadam dwara jeevakriya retunu taggistaayi. electronlanu samarthavantamgaa badilee cheyaleka, kanaantara naad +/naad nishpatti taggutundi, idhi phosphotidilinosital-3-kines mariyu extra cellular signal-regulated kineslanu sakriyam chestundi. idhi, "sii-juun" transcription niyantristundi, "surr2" pramotartho bandhinche proteinnu srushtistundi.
cellular aakseekarana ottidi mariyu perigina cotp utpatti madhya sambandham yokka oka mukhyamaina chikkulu emitante, mottam potassium ravana paniteeru eee chaanella pora gaadataku neerugaa anulomaanupaatamlo untundi. madhumeham sandarbhaalalo, cotp chaanallu sarigga panicheyavu, mariyu telikapati cardiac ischemia mariyu hypoxiacu gurtinchadagina sunnitatvam pratikuula aakseekarana paristhitulaku anugunamgaa kanaalu asamarthatha phalitamgaa untundi.
metabolite niyantrana.
cotp chaanal teravadaanni nirdishta sammelanaalu niyantrinchagala sthaayi kanajaala rakanni batti maarutuu untundi, inca marinta pratyaekamgaa, kanajaalam yokka praadhamika jeevakriya uparitalamtho maarutuu untundi.
pancreatic beata kanaalalo, eah. tii. pii. anedi praadhamika jeevakriya muulam, mariyu eah. tii. pii/eah. dii. pii nishpatti cotp chaanal kaaryaacharananu nirnayistundi. vishraanti paristhitulalo, pancreatic beata kanaalalo balaheenamgaa lopali sarichese cotp chaanallu aakasmikamgaa churukuga untaayi, idhi potassium ayanlu kanam nundi bayataku pravahinchadaaniki mariyu pratikuula vishraanti pora saamarthyaanni (k + reversal sambhaavyata kante konchem ekkuva saanukuula) nirvahinchadaaniki veelu kalpistundi. adhika glucose jeevakriya samakshamlo, mariyu tatphalitamgaa saapeksha sthaayilanu penchina eah. tii. pii., cotp chaanallu muusivaeyabadataayi, deenivalla kanam yokka pora saamarthyam vidhvamsam chendutundi, voltage-gated calcium chaanellanu sakriyam chestundi, tadwara calcium-aadhaarita insulin vidudalanu prothsahistundi. sameepa cotp chaanal anuvula madhya sii-terminus multimerisation kaaranamgaa oka sthithi nundi maroka sthithiki maarpu twaragaa mariyu samakaaleekaristundi.
marovaipu, cardiomyocytelu, vaati saktilo ekkuva bhaganni podavaina golusu kovvu aamlalu mariyu vaati asail-koo samaanamaina vaati nundi pondutaayi. cardiac ischemia, kovvu aamlaala aakseekarananu nemmadistundi, idhi asail-koo perukupovadaniki kaaranamavutundi mariyu cotp chaanal teravadaaniki prerepistundi, ayithe uchita kovvu aamlalu daani closed conformation sthireekaristaayi. eee vaividhyam transgenic elukalanu pariseelinchadam dwara pradarsinchabadindi, ivi eah. tii. pii-sunnitamaina potassium chaanellanu kaligi undataaniki penchabaddaayi. clomum loe, eee margalu ellappuduu terichi untaayi, conny hridaya kanaalalo muusivaeyabadataayi.
mitochondrial cotp mariyu aerobic jeevakriya yokka niyantrana.
cellular shakti sankshobham praarambhamaina tarvaata, mitochondrial paniteeru ksheenistundi. pratyaamnaaya antargata pora sambhaavyata, asamatulya trans-membrane ayan ravana mariyu free radicals yokka adhika utpatti, itara kaarakaalato paatu dheeniki kaaranam. atuvanti paristhitiloo, antargata ca2 + ekagrata mariyu pora vaapu sthaayi rendintinee niyantrinchadaaniki mitocotp chaanallu teruchukuntaayi mariyu daggaragaa untaayi. idhi saraina pora saamarthyaanni punaruddharinchadaaniki sahaayapadutundi, marinta h + pravahanni anumatistundi, idhi mitochondrial ATP samshlaeshanhaku avasaramaina protan pravanatanu andistuunee undhi. potassium chhaanals nundi sahayam lekunda, adhika shakti fasfate ksheenata pratikuula electrochemical pravanataku vyatiraekamgaa etipini srushtinchagala retunu adhigamistundi.
anhu mariyu sarcolemmal cotp chaanallu kooda jeevakriya ottidi nundi sahanam mariyu punaruddharanaku dohadam chestaayi. saktini aadaa cheyadaaniki, sarcotp open, action potential vyavadhini taggistundi, ayithe nucleus lopala nakatp-madhyavartitva CA2 + ekagrata maarpulu rakshita protein janyuvula vyakteekaranaku anukuulamgaa untaayi.
hridayanaala cotp chaanallu mariyu ischemic gaayam nundi rakshana.
cardiac ischemia, ellappuduu ventane praanaantakam kaanappatikee, tarachugaa necrosis dwara cardiomyocyte maranaaniki daariteestundi, idhi gunde kandaraalaku shaashwata gaayam kaligistundi. 1986loe keeth reimer modatisaarigaa vivarinchina oka paddhatiloo, prabhaavita kanajaalaanni pradhana ischemic avamaanaaniki mundu ischemia yokka kluptamaina, praanaantakamaina kaalaalaku (3-5 nimishalu) guricheyadam untundi. eee prakriyanu ischemic prii conditioning ("ipc") anie pilustaaru, mariyu daani prabhavanni, kaneesam kontavaraku, cotp chaanal uddeepana nundi pondutundi.
ipc daani garishta prabhavalanu kaligi undataaniki sarcotp mariyu mitocotp rendoo avasaram. 5-hydroxydecanoic aamlam ("5-hechdi") ledhaa emsisi-134 thoo empika chesina mitocotp digbandham ipc andinche cardioprotection puurtigaa nirodhistundi, mariyu elukalalo sarcotp janyuvula janyu nock avt adavi rakamaina elukalatho poliste besal sthaayini penchutundani choopabadindi. eee praathamika rakshana anedi kandaraala sankocham samayamlo cellular ca2 + overloading mariyu shakti abhivruddhi yokka maandyaanni nivaarinche sarcotp yokka saamarthyam phalitamgaa untundani nammutaaru, tadwara arudaina shakti vanarulanu parirakshistundi.
sarcotp lekapovadam, ipc yokka prayojanaalanu tagginchadamtho paatu, ca2 + nuu sarigga pampinhee cheyagala myocyte saamarthyaanni gananeeyamgaa balaheenaparustundi, saanubhootigala naraala sankethaalaku sunnitatvaanni taggistundi mariyu arithmia mariyu aakasmika maranaaniki gurayye avakaasam undhi. adevidhamgaa, sarcotp vascular smooth kandaraala tone niyantristundi, mariyu "kir6.2" ledhaa "surr2" janyuvulanu tolaginchadam coronary artary vasospasum mariyu maranaaniki daariteestundi.
cardiac rhythm regulationlo sarcotp paatranu marinta anveshinchina taruvaata, chhaanel yokka utparivartana roopaalu, mukhyamgaa surr2 sub unitloni utparivartanalu, mukhyamgaa ischemia/reperfusion tarvaata, vistarinchina cardiomayopati kii kaaranamani kanugonabadindi. cotp chaanellanu teravadam valla puurtigaa anukuula ledhaa antiarrhythmic prabhavalu untaya anedi inca aspashtamgaa undhi. perigina potassium conductains ischemic avamaanaala samayamlo pora saamarthyaanni sthireekaristundi, inforkt mariyu ectopic pays maker karyakalapalanu taggistundi. marovaipu, potassium chaanal teravadam anedi charya sambhaavyata yokka punahdhruveekarananu vegavantam chestundi, bahusha arithamic reeentreeni prerepistundi.

