
nenitzescoo indol samslaeshanha

nenitgesku indol samslaeshanha anedi benzoquinan mariyu β-aminocrotonic esterla nundi 5-hydroxyindol utpannaalanu yerparustundi.
eee praticharyaku daani aavishkarta ayina castin nenitesku paeru pettaru, athanu dheenini 1929loe modatisaarigaa nivedinchaadu. dheenini methyl, methoxy, ethyl, propyl mariyu hetch pratyaamnaayaalato sahaa aneka vibhina aarr-samuuhaala kalayikalatho nirvahinchavacchu. atyanta cross-linked polymer paranjaapai praticharya jarige ghana-sthithi vaividhyam kooda undhi. samslaeshanha mukhyamgaa aasaktikaramgaa untundi endukante neurotransmitterlu mariyu kotta taragati antitumer sammelanaalato sahaa aneka jeevarasaayana mukhyamaina anuvulaku indoles punaadi.
yantraangam.
nenitgesku praticharya yokka yantraangam maikhel jodimpunu kaligi untundi, taruvaata enamine paie bandham dwara nucleophilic daadi, aapai tolagimpu untundi.
eee pratispandananu modatisaarigaa 1929loe nenitgesku prachurinchaaru, appati nundi dheenini allen mariyu itarulu suddhi chesaaru."thana 1996 prachuranalo, allen mariyu sahodyogulu benzoquinan prarambha padaarthampai vividha pratyaamnaayaalu tudi utpatti yokka amarikapai choope prabhavalanu parisoedhimchaaru. eee steric prabhavalu prastuta pratipaadita rendu yantraamgaalalo okati marokati kante ekkuvagaa undataaniki sakshyalanu icchaayi, idhi paina chuupina yantraangam prachuranaku daariteesindi.
paristhitulu.
katkevika mariyu itarulu nirvahinchina praathamika adhyayanam."nenitgesku samslaeshanha kosam pratispandana paristhitulanu parisoedhimchi, vividha dravakalalo jariginappudu pratispandana yokka pravartana gurinchi nivedinchaaru. vaati phalitaalu adhika dhruva draavanamloo praticharya uttamamgaa panichestundani suuchimchaayi, mariyu uparitalam, karakalu, draavakaala vaividhyam mariyu levis aamlalu mariyu kshaaraala unikini kaligi unna marinta gathi adhyayanalu pratipaadinchabaddaayi. rendu samvatsaraala taruvaata, velejeva mariyu itarulu."levis assid utprerakaanni upayoginchi samslaeshanha yokka pratyaamnaaya samskarananu nivedinchaaru. dicotodianamine-gncl2 complexes dwara enamine kriyaaseelata nundi utpreraka prabhavam udbhavinchindani vaaru nivedinchaaru.
ayithe, paristhitulalo merugudalalu unnappatikee, saadhaarana praticharya paristhitulalo saapekshamgaa takkuva digubadi mariyu polymerisation kaaranamgaa saampradaaya nenitgesku samslaeshanha tayari sthaayilo upayoginchadaaniki anukuulamgaa ledhu. modata, eee sthaayilo puurti kaavadaaniki pratispandananu nadapadaniki benzoquinannu 100% adanapu upayoginchaalsi untundani nammutaaru, conny huwang mariyu itarulu. 20-60% adanapu atyanta prabhaavavantamgaa untundani nivedinchaaru. antekakunda, pedda ettuna praticharyaku anuvaina paristhitulaku, benzoquinan mariyu eethail 3-aminocrotonate madhya 1:1.2-1.6 moll nishpatti undaalani, praticharya gadhi ushnograta chuttoo jaragalani vaaru nivedinchaaru. 100 kilolu ledhaa anthakante ekkuva byaachlanu utpatti cheyadaaniki eee paristhitulu saripothayi.
vaividhyaalu mariyu sambandhita praticharyalu.
nenitgesku praticharya yokka atyanta saadhaarana vaividhyaalalo okati ghana dasha roopaantaram. eee praticharyanu modata kecha mariyu itarulu nivedinchaaru.", krinda choopabadindi.
idhi atyanta cross-linked argopore ®-rink-enhetch-efmoke resinpy jarugutundi mariyu rendu reactantlapy vividha rakaala pratyaamnaayaalato panichestundi. itara ghana-dasha indol samshlaeshanhalu kooda nivedinchabaddaayi, veetilo konni puurti kaavadaaniki pratispandananu nadapadaniki vividha paranjaalu mariyu loha utprerakaalanu upayogistaayi.
adhe indol asthipanjaraaniki daariteese aneka itara praticharyalu kooda unnaayi. sameeksha vyaasamlo, tobber "mariyu itarulu."eee praticharyalanu tommidi praathamika rakaala indol samshlaeshanhalugaa vargeekarinchandih fisher, mori, hemetsberger, butchwald, sundberg, madelung, nenitgesku, vaan lusen mariyu kanematsu.
applications.
5-hydroxyindol asthipanjaram aneka jeevarasaayana mukhyamaina anuvulaku punaadi. vaatilo serotonin, oka neurotransmitter; indometacin, oka steroid kaani shotha nirodhaka agent; ell-761,066, oka cox-2 nirodhakam; mariyu lye 311727, sraavam phospholipase nirodhakam. prastutam, nenitgesku samslaeshanha yokka atyanta aasaktikaramaina anuvartanaallo okati antitumer sammelanaalaku puurvagaamini utpatti cheyagala saamarthyam. 2006loe nivedinchabadina eee samshlaeshanhaloo, vividha enaamainlatoe 1,4,9,10-antradiquinone yokka praticharya untundi. eee praticharya yokka utpattulu cancer nirodhaka aushadha roopakalpana kosam kotta taragati seesam nirmaanaalanu kaligi untaayi.

