
killer sell immunoglobulin lanty receptor 2dl3

kirr2dl3, killer sell immunoglobulin lanty receptor 2dl3 anedi sahaja killer kanaalu mariyu tii kanaala upasamitula dwara vyakteekarinchabadina transmembrane glycoprotein. kirr janyuvulu bahuroopamainavi, antey avi aneka vibhina yugmavikalpalanu kaligi untaayi. kirr janyuvulu kooda chaalaa sajaateeyamainavi, antey avi sthaanam, nirmaanam mariyu parinaamaatmaka moolamlo saruupyamgaa untaayi, conny tappanisarigaa paniteerulo undavu.
sahaja killer (enn. keey) kanaalu sahaja antiviral roganirodhaka pratispandanalo mukhyamaina bhaagam. mundastu sensitization antigen lekunda lakshya kanaalanu lies cheyagala saamarthyam kaligi untaaru mariyu keymokin adaptive mariyu cytokinlanu sravinchadam dwara roganirodhaka pratispandanalanu niyantristaaru. enn. keey. kanaala kriyaaseelata anedi nirodhaka sankethaala ekikarana mariyu vividha graahakaala yokka aneka kutumbaalache jaarii cheyabadina kriyaaseelata dwara nirnayinchabadutundi, veetilo killer sell immunoglobulin-lanty grahakaalu (kirr) unnaayi, ivi pradhanamgaa class I maanava leukocyte antigen (hcla) yokka antigenlanu gurtistaayi.
nirmaanam mariyu sthaanam.
kirr proteinla kodingku baadhyata vahinche janyuvulu 1 embi leukocyte receptor complexes (lrc) lopala 19va chromosome vibhagam 19 kyuu 13.4 venta kanipistaayi. kirr proteinla upasamitulu vaati extra cellular aiji domainla sankhya mariyu avi podavaina (ell) ledhaa chinna (luu) cytoplasmic domine-thokanu kaligi unnaya anae daani dwara vargeekarinchabadataayi. protein paeru chivarilo vachhe sankhya daanini daaniki chendina upasamiti yokka saakhagaa vargeekaristundi.
function.
protein kirr2dl3 podavaina thoka gala cytoplasmic domaine kaligi untundi mariyu immunoreceptor tyrosine-aadhaarita nirodhaka muulaamsam (itim) dwara ligand binding meeda nirodhaka sanketaanni prasaram chestundi. protein yokka ligandlu anedi hcla-sii anuvula upasamitih hcla-sidablue1, hcla-sidablue3, hcla-sidablue7. roganirodhaka pratispandanalanu niyantrinchadamlo protein mukhyamaina paatra pooshistundani bhaavistunnaaru. hcla-sii anuvulu maanava leukocyte antigenlu mariyu maanavulalo pradhana hystocompatibility complexes (emhechsi) proteinlanu encode cheyadaaniki janyu samudaayaalu. hcla anedi bahuroopamainavi, anduvalla maanavula emhechseelu oka vyakti nundi marokariki bhinnamgaa untaayi. kirr2dl3 anedi rendu extracellular domainla protein complexes mariyu podavaina thoka gala endo-cellular cytoplasmatic thoka, idhi sell antataa inhibitory signals pampadaaniki baadhyata vahistundi.
pathology.
protein kirr2dl3 roganirodhaka tyrosine-aadhaarita nirodhaka muulaamsam (itim) dwara ligand binding meeda daani podavaina lopali cytoplasmic thokaku nirodhaka sankethaalanu badilee chestundi. tyrosine kines aadhaarita transductions anevi oka fasfate samuuham yokka enzymatic badileelu, ivi oka eah. tii. pii anuvu nundi kanamlooni proteinku badilee avtayi. eee vidhamgaa aneka cellular functionlalo 'aann' mariyu 'off' switchga panichestundi. tyrosine kineslu protein-kines yokka upa-taragati. cellular karyakalapalanu niyantrinchadaaniki kanamlooni sankethaala badileeloo proteinla phosphorylation anedi avasaramaina dasha. protein kineslu 'off' sthithilo chikkukuni, manchi kosam kana punarutpattini nirodhinchavacchu, ledhaa dheeniki viruddhamgaa 'aann' sthithilo chikkukovacchu, tadwara kanaanni aniyantritamgaa punarutpatti cheyadaaniki veelu kalpistundi, idhi cancer abhivruddhiki avasaramaina dasha.