
pitidi-dbm

protein transduction domine-fused disheveld binding motif (pitidi-dbm) anedi maanava nirmita peptide, idhi juttu nashtam anusandhaaninchabadina endogenous protein "cxxc5" yokka yantraamgamtho sankarshana chendutundi, idhi doubluenty/β-catainin maargam yokka pratikuula pratispandana niyantrakam."battatala prayogasaala elukalaku peptidenu upayoginchadam valla kotta juttu kudulla perugudala erpadindi.
ptd-dbm anedi oka peptide, idhi cxxc5 yokka binding yokka jokyam dwara panicheyadam dwara Wnt/β-catainin signalling marganni sakriyam chestundi, idhi Wnt/β-catainin maargamloni upstream bhaagam. samayochita anuvartanam dwara, pitidi-dbm kotta juttu kudulla nirmaanaanni prothsahistundi mariyu juttu raladanni nirodhistundi. valproic aamlam (vpa) thoo pitidi-dbm yokka mishrama chikitsa, doubluenty/β-catainin maargam yokka activator, juttu tirigi perugudalanu alaage gaayam-prerita juttu neogenesis (vihn) nuu marinta prerepistundi. battatala scalps loe cxxc5 yokka perigina vyakteekarana mariyu elukalalo juttu perugudalapai pitidi-dbm yokka adbhutamaina prabhavalu cliniclo juttu perugudalapai eee peptide yokka application kosam aasalanu penchaayi.
pitidi-dbm aavishkarana.
dakshina korealoni yonsi vishwavidhyaalayamlo professor kaang-yael choyi mariyu athani parisoedhanaa brundam androgenetic alopesia anie piluvabade paristhitiloo juttu raaladaaniki kaaranamayye proteinnu kanugonnaru. baadhyataayutamaina proteinnu cxxc-rakam jink finger protein 5 (cxxc5) anie pilustaaru, idhi juttu punarutpatti mariyu gaayam nayam cheyadamlo palgone doubluenty/β-catainin maargaaniki pratikuula niyantrakam vale panichestundi. cxxc5 pratikuulamgaa juttu perugudalanu niyantristundi, mariyu parisoedhakulu cxxc5 yokka paniteerunu niyantrinchadam dwara juttu punarutpattini prothsahinche kotta padaarthaanni abhivruddhi chesaaru. cxxc5 dvl proteintho bandhinchinappudu, idhi Wnt/β-catainin maargam yokka eguvana panichestundi, idhi juttu perugudala mariyu juttu kudulla neogenesisnu anichivestundi. professor choyi brundam battatala talapai cxxc5 atigaa vyaktaparachadaanni gamaninchadam valla pitidi-dbm abhivruddhi chendindi, idhi cxxc5-dvl protein-protein paraspara charya (ppi) loe jokyam chesukuntundi. samayochita anuvartanam dwara, pitidi-dbm juttu perugudalato paatu neogenesisnu penchutundi. saadhaaranamgaa bipolar desorder kosam aushadhamgaa upayoginche mariyu gsk3β nirodhinchadam dwara WNT/β-catainin marganni sakriyam chese vPA vanti WNT/β-catainin signalling activatortho kalipi upayoginchinappudu ptd-dbm yokka juttu perugudalanu prothsahinche prabhavam marinta merugupadutundi. prastutam, juttu raladam chikitsa kosam pitidi-dbm ledhaa vpatho daani kalayika yokka samayochita anuvartanam upayoginchabadindi.

