
holocarboxylase synthetase

protein-biotine ligase anie kooda piluvabade holocarboxylase synthetase (biotine-(propional-kmjime eah-carboxylase (eah. tii. pii-hydrolysing)) ligase) anedi enjaimla kutumbam (). kaaleyam, guddu pacchasona mariyu paalu vanti aaharalalo kanipinche biotine, eah bii vitamin yokka samarthavanthamaina viniyogaaniki eee enjaim mukhyamainadi. sariiramlooni aneka kanajaalaalo, holocarboxylase synthetase itara nirdishta enjaimlanu (biotine-aadhaarita carboxylase anie pilustaaru) biotine jodinchadam dwara sakriyam chestundi. eee carboxylaselu proteins, kovvulu mariyu carbohydratela utpatti mariyu vichchinnamtho sahaa aneka klishtamaina cellular vidhullo palgontayi.
utpreraka praticharyah
eee enjaim yokka 3 uparitalaalu eah. tii. pii, biotine, mariyu, ayithe daani 3 utpattulu ampere, diphosphate mariyu.
janyuvula karyakalapalanu niyantrinchadamlo holocarboxylase synthetase kooda paatra pooshinchavachchu. kendrakamlo, enjaim bahusha biotine anuvulanu histonelaku jodistundi, ivi dnatho bandhinchi chromosomelaku vaati aakaraanni ichhe nirmaanaatmaka proteins. histonela aakaraanni marchadam valla konni janyuvulu aann ledhaa off cheyabadindo ledho nirnayinchadaaniki sahaayapadavachhu; ayithe, biotine jodinchadam janyu niyantrananu elaa prabhaavitam chestundo teliyadu.
hclcs janyuvu chromosome 21 yokka podavaina (kyuu) bhujampai bays jatha 37,045,059 nundi bays jatha 37,284,372 varaku 22.1 sthaanamlo undhi.
sambandhita paristhitulu.
holocarboxylase synthetase lopamh holocarboxylase synthetase lopam unnavaarilo hclcs janyuvulo sumaru 30 utparivartanalu gurtinchabaddaayi. eee utparivartanallo chaalaa varaku holocarboxylase synthetase enjaimloni maroka amaino aamlaaniki oka amaino aamlam (proteinla building block) nuu pratyamnaayamgaa istayi. telisina aneka utparivartanalu biotine thoo bandhinche enjaim yokka praantamloo sambhavistaayi. eee utparivartanalu carboxylaselu mariyu histonelaku biotine jodinche enjaim saamarthyaanni taggistaayi. biotine lekunda, carboxylaselu kriyaarahitamgaa untaayi mariyu proteins, kovvulu mariyu carbohydratelanu proses cheyalevu. holocarboxylase synthetase charya lekapovadam kooda saadhaarana abhivruddhiki mukhyamaina konni janyuvula niyantrananu maarchavacchu. mukhyamaina cellular vidhullo eee antaraayaalu swaasa samasyalu, charma daddurlu mariyu holocarboxylase synthetase lopam yokka itara lakshana sankethaalu mariyu lakshanaalaku daariteestaayani parisoedhakulu bhaavistunnaaru.

