kaaleya punarutpatti

kaaleya punarutpatti anedi kaaleyam kolpoyina kaaleya kanajaalaanni bharti cheyagala prakriya. punarutpatti saamarthyam kaligina ekaika viseral orgaon kaaleyam. pakshika shastrachikitsa tolagimpu ledhaa rasayana gaayam tarvaata kaaleyam punarutpatti cheyavachu. avayavam tirigi puurti parimaanaaniki tirigi raavadaaniki asalu kaaleya dravyaraasilo 51 saatam varaku avasaram. ksheeradaalalo punarutpatti prakriya pradhanamgaa parihara perugudala endukante kaaleyam yokka kolpoyina dravyarashi bharti cheyabadinappatiki, adhi daani asalu aakaraanni tirigi pondadu. compensatory hyperplasia samayamlo, migilina kaaleya kanajaalam peddadigaa maarutundi, tadwara avayavam panicheyadam konasaagistundi. chepalu vanti takkuva jaatulalo, kaaleyam daani asalu parimaanam mariyu dravyarashi rendintinee tirigi pondagaladu.
yantraangam.
kaaleyam punarutpatti cheyagala rendu rakaala nashtalu unnaayi, okati pakshika hepatectomy mariyu marokati vishapadaardhaalu ledhaa sankramana dwara kaaleyaaniki nashtam kaliginchadam. pakshika hepatectomy taruvaata punarutpattini eee krindivi vivaristaayi.
pakshika hepatectomy taruvaata, punarutpatti moodu dasallo jarugutundi. modati dasha praathamika dasha. eee bhaagamlo, vandalaadi janyuvulu sakriyam cheyabadataayi mariyu punarutpatti kosam kaaleyaanni siddham chestaayi. eee praathamika dasha hepatectomy jarigina 5 gantallone sambhavistundi mariyu pradhanamgaa kana chakramloki pravesinche mundu jarige sanghatanalatho vyavaharistundi mariyu hepatocytelu vaati homeostatic vidhulanu nirvahinchelaa chusukuntundi. rendava dasalo ii. zii. eff. aarr (epidermal groth phyaaktar receptor) mariyu sii-mett thoo sahaa vividha vruddhi kaarakaalanu sakriyam cheyadam untundi. eee rendu amsaalu kaaleya punarutpattilo pradhana paatra poeshistaayi. chivari dasha tgf-β (vruddhi kaaraka beata) dwara vistarananu raddu cheyadam.
hepatectomy jarigina ventane, aneka sanketha margalu punarutpatti prakriyanu praarambhinchadaaniki sakriyam chestaayi. modatidi eurokiness karyakalapalalo perugudala. eurokiness maatrika punarnirmananni sakriyam chestundi. eee punarnirmaanam hcgf (hepatic groth phyaaktar) vidudalaku kaaranamavutundi mariyu eee vidudala nundi, idhi sii-mett mariyu egfr vruddhi kaarakaala vidudalanu sakriyam chestundi. eee rendu vruddhi karakalu punarutpatti prakriyaloo pradhana paatra poeshistaayi. eee prakriyalu hepatocyte velupala mariyu punarutpatti kosam kaaleyam yokka pradhana bhaagamlo sambhavistaayi. eee prakriyalu puurtayina tarvaata, hepatocytelu kaaleyamloki pravesinchi vistarana prakriyanu praarambhinchagalavu. endukante β-catainin (hepatocyte lopala) mariyu vruddhi karakalu egfr mariyu c-met (hepatocyte velupala) madhya communication undhi. hepatosectomy jarigina sumaru 15-30 nimishala tarvaata hepatocyte yokka kendrakaaniki β-catainin mariyu naach-1 taralimpu kaaranamgaa eee communication sambhavinchavachhu. eee rendu proteinla uniki punarutpaadaka pratispandananu penchutundi mariyu hcgf mariyu egfr pratyaksha mitogenluga panicheestaayi mariyu hepatocytelu vistarinchadaaniki balamaina mitogenic pratispandananu utpatti cheyagalavu.
punarutpatti prakriya puurtayina tarvaata, tgf-bita apoptosisnu prerepinchadam dwara vistaranaku mugimpu palukutundi. palukutundi hcgf nii anachiveyadam dwara hepatocytela vistarananu nirodhistundi. paina paerkonnatlugaa, eurokiness hcgf vidudalanu sakriyam chesindi; anduvalla, anduvalla kooda eurokiness karyakalapalanu anichivestundi. eee prakriya hepatocytelanu vaati prasaanta sthithiloki tirigi teesukuraagaladu.
konnisaarlu, hepatocytelu vistarinche saamarthyaanni kaligi undavu mariyu kaaleyaanni punarnirminchadaaniki punarutpatti yokka pratyaamnaaya roopam jaragavacchu. hepatocytelu peraganipudu, pitta epithelial kanaalu hepatocyteluga maragalavu. pitta kanaalu peraganipudu hepatocytelu pitta kanaalugaa maaradamtho kooda dheeniki viruddhamgaa sambhavinchavachhu. eee vidhamgaa, hepatocytelu mariyu pitta kanaalu okadaanikokati facultative stem sels. facultative stem sels sareeramlo rojuvaaree paniteerunu kaligi untaayi, conny aaa kanaalu debbatinnappudu itara rakaala kanaalaku stem selsga kooda panicheestaayi. kaaleya punarutpatti yokka saadhaarana vidhanam viphalamainappudu kooda eee rendu rakaala kanaalu kaaleya kanajaalaanni saricheyagalavu.
kaaleya nashtam.
lekapothe aarogyakaramaina rogulalo, kaaleyam 30 rojullo daani dravyaraasini sagam varaku punarutpatti cheyagaladu. itara samasyalu unte, kaaleyam macchalu modalavavacchu ledhaa kaaleyam puurtigaa punarutpatti kaavadaaniki mundhe punarutpatti aagipovachhu. kaaleyamlo macchalu chaalaa pramaadakaramainavi mariyu marinta samasyalu mariyu kaaleya vyaadhiki daariteestaayi. kaaleyaaniki nashtam kaliginche prarambha kaaranam ippatikee unnappudu samasyalu perugutaayi. vairaslu, madyam, mandulu mariyu itara kaarakaala valla kaaleya nashtam sambhavinchavachhu.
aneka pratyaksha mandulalo kanipinche acetaminophen, tappugaa teesukunte kaaleyaaniki nashtam kaliginche atyanta saadhaarana aushadham. acetaminophen adhika motaadu kaaranamgaa chaalaa mandhi kaaleya marpidi rogulaku vaari marpidi avasaram.
kaaleya vyaadhi.
sankramana, roganirodhaka vyavastha asaadhaaranata, janyusaastram, cancerlu, madya durviniyogam, kaaleyamlo kovvu perukupovadam, prescription mandulu mariyu mulika sammelanaalato sahaa kaaleya vyaadhini prerepinchadaaniki aneka margalu unnaayi. kaaleya vyaadhulu abhivruddhi chendhe sambhaavyatanu penche karakalu oobakaayam, type 2 diabetes, pachchabotlu ledhaa shareera kutlu, bhaagaswaamya suudulanu upayoginchi mandula injection, itara vyaktula raktam mariyu shareera dravaalaku gurikavadam, asurakshita laingika samparkam mariyu rasayanalu mariyu vishapadaarthaalaku gurikavadam vantivi.
eee vyaadhulalo konnih
hepatitis eah, hepatitis bii, mariyu hepatitis sii
praathamika pitta colangitis mariyu praathamika sclerosing colangitis
kaaleya cancer, pitta vaahika cancer, mariyu kaaleya kana adenoma
haemochromatosis, hyperoxaluria mariyu willson vyaadhi
rooga nirdhaarana.
kaaleya vyaadhi chikitsaku kaaleya nashtam roopaalanu bahirgatam cheyadam chaalaa mukhyam; rooga nirdhaarana samayamlo, mea vaidyudu mea aushadham mariyu madyam durviniyogam charitra gurinchi mariyu debbatinna kaaleyam mariyu kaaleya vyaadhiki dohadapade edainaa janyu paristhitula gurinchi adugutaaru. konni sifaarsu cheyabadina pareekshalalo rakta pareekshalu, imaging pareekshalu mariyu kaaleya biopsy unnaayi. mea raktamlooni vishapadaarthaalanu tanikhi cheyadam dwara mea kaaleyam sarigga panichestundo ledho mea vaidyudiki rakta pareeksha teliyajestundi. imaging pareekshalu mea vaidyudini mea kaaleyam yokka mottam saareeraka paristhitini chuudataaniki anumatistaayi; eee pareekshalalo ultrasoundlu, siti skaanlu mariyu mislaku matrame parimitam kakapovachhu. chivaraku, mea vaidyudu biopsy nirvahinchadam dwara mariyu kanajaala kanaalanu debbatinadaaniki tanikhi cheyadam dwara mea kaaleyam namuunaanu tolaginchavacchu. biopsylo kaaleyam nundi kanajaalaanni velikiteese charmam mariyu pakkatemukala dwara podavaina suudini choppinchadam untundi. kaaleyam ledhaa vyaadhiki jarigina nashtam rakanni batti, eee rooga nirdhaaranaku chikitsa maaravacchu. chaalaa chinna kaaleya samasyalaku chikitsa mea jeevanasaililo saadhaarana maarpulatoe praarambhamavutundi; madyam viniyogam ledhaa baruvu taggadaanni tagginchadam anedi chikitsa prakriyaloo praamaanika bhaagam. marinta sanklishtamaina samasyalaku ablation ledhaa embolisation vanti marinta prameyam ledhaa chorabaatu prakriyalu avasaram kaavacchu. chikitsa anedi rooga nirdhaaranapai aadharapadi untundi, idhi prati kesu praatipadikana untundi. 
function.
kaaleyam chaalaa avayavalaku homeostasis mariyu jeevakriyatho vyavaharistundi, carbohydratela nilvagaa panichestundi mariyu mukhyamgaa aushadha nirvisheekarana yokka pradhana pradaesam, idhi sariiramlooni aneka rasaayanaalaku guravutundi, idhi kanaala maranam mariyu gayanni prerepistundi. kaaleyam debbatinna kanajaalaanni vaegamgaa punarutpatti cheyagaladu, tadwara kaaleya vaiphalyaanni nivaaristundi. ayithe, kaaleya punarutpatti vegam interleukin 6 atigaa vyakteekarinchabadindaa anae daanipai aadharapadi untundi. fibrosis mariyu kanitulu vanti kaaleya vyaadhulu unna rogulaku kaaleya punarutpatti kooda keelakam, endukante kaaleyamloni prabhaavita bhaagaalanu rogiki shaashwata kaaleya lopam lekunda tolaginchavacchu.
puraanamloo.
greeku puraanaalaloo, promatheus mariyu titios devatalaku vyatiraekamgaa atikramana chesevaaru, vaari sikshalalo vaari kaaleyaanni pagatipuuta vaeta pakshulu tintaayi mariyu raatri puuta punarutpatti chestaayi. ayithe maanava kaaleyaalu punarutpatti cheyagalavani puraatana prajalu ardham chesukovadam asambhavam.

