
methyl floro acetate

methyl fluoroacetate (mfa) anedi fluoroacetic aamlam yokka atyanta vishapuurita methyl eestar. idhi gadhi ushnograta vadda ranguleni, vaasana laeni dravam. dheenini prayogasaala rasayanamga mariyu elukanaasakamgaa upayogistaaru. daani teevramaina vishapuuritam kaaranamgaa, mfa rasayana aayudhamgaa sambhaavya upayogam kosam adhyayanam cheyabadindi. saadhaarana janabha methyl fluoroacetate baarina padee avakaasam ledhu. ayithe, pani kosam mfnu upayoginche vyaktulu, oopiri peelchukovacchu ledhaa padaarthamthoo neerugaa charma sambandhaanni kaligi undavacchu.
charitra.
1896loe belgian rasayana shaastravetta swart methyl iodoacetate sylver fluoridetho pratispandinchadam dwara mfani modatisaari samslaeshanha chesaaru. methyl chloroacetate potassium fluoridetho pratispandinchadam dwara kooda dheenini samslaeshanha cheyavachu. 
daani vishapuuritam kaaranamgaa, rendava prapancha yuddhamlo rasayana aayudhamgaa sambhaavya upayogam kosam mfa adhyayanam cheyabadindi. idhi rangulenidi mariyu vaasana laenidi kabatti idhi manchi neeti vishamgaa pariganinchabadindi, anduvalla idhi neeti sarafaraanu vishapuuritam chestundi mariyu janabhalo ekkuva bhaganni champutundi. yuddham mugise samayaniki, aneka deshaalu satruvunu balaheenaparachadaaniki ledhaa champadaaniki methyl fluoroacetate tayaaru cheyadam praarambhinchaayi.
samslaeshanha.
methyl floro acetate samslaeshanha rendu dasala prakriyanu kaligi untundih
nirmaanam mariyu praticharya.
methyl floro acetate anedi oka methyl eestar. eee nirmaanamloo carboxylic aamlam oka kriyaatmaka samuuhamgaa mariyu florin anuvu untundi. 
mfa anedi oka dravam, idhi vaasana laenidi ledhaa masaka, falaala vasananu kaligi untundi. mfa yokka marige sthaanam 104.5 masim mariyu draveebhavana sthaanam-35°sii. idhi neetilo karugutundi (1.17x10 + 5 mg/l 25 °C vadda) mariyu petrolium eetharlo koddigaa karugutundi.
nucleophiles dwara florin sthaanabhramsamku mfa nirodhakatanu kaligi untundi, kabatti itara hologenlatho (kl, br) poliste sii-eff bandham yokka adhika sthirathvam untundi. itara haalo asitetlu marinta saktivantamaina alkylating agentlu, ivi-shaa proteinla samuuhamtoe pratispandistaayi. ayithe, idhi mfa vishayamlo jaragadu mariyu dheeniki oka pratyaekamaina vishapuurita charyanu istundi. antekakunda, mfa anedi fluoroacetate (efae) sammelanam nundi utpannam, idhi vishapuuritamainadi mariyu mfa maadirigaane jeeva parivartananu kaligi untundi.
charya mariyu jeevakriya yokka yantraangam.
saadhaaranamgaa, fluoroacetatelu vishapuuritamainavi endukante avi fluoroacetyl kmjime eah nundi fluoresitratega maarchabadataayi. fluoresitrate pootii nirodham dwara citrate maarpidiki avasaramaina aconitate hydratesnu nirodhinchagaladu. idhi citric assid saikil (tii. sii. eah. saikil) kuu antaraayam kaligistundi mariyu citrate kanajaalaalo mariyu chivariki plasmalo perukupovadaniki kooda kaaranamavutundi. mfa pradhanamgaa rendava dasha biotransformation prakriyaloo glutathione transferes enjaim dwara biotransformation cheyabadutundi. gshech-aadhaarita enjaim glutathione mfaku jatachestundi, tadwara mfnu defluorinate chestundi. phalitamgaa, fluoride ayan mariyu ess-carboxymethyl glutathione utpatti avtayi. fluoride yokka vidadeeyadam anedi fluoroacetate-nirdishta defluorinase dwara madhyavartitvam vahistundi. defluorinating charya pradhanamgaa kaaleyamlo untundi, conny moothrapindaalu, oopiritittulu, gunde mariyu vrushanhaalu kooda kaaryaacharananu chuuputaayi. medadulo, defluorination sankethaalu laevu. chivariki, fluoresitrate (effsy) erpadutundi, idhi pradhana vishapuurita sammelanam. idhi aconitase enjaimnu chaalaa ekkuva anubandhamtho bandhistundi mariyu anduvalla tii. sii. eah. chakramlo jokyam chesukuntundi. saadhaarana paristhitulalo citrate suisinatega maarchabadutundi, conny prakriya nirodhinchabadutundi. chakram aagipotundi mariyu aakseekarana phosphorylation nirodhinchabadutundi endukante tii. sii. eah. chakram nundi naad, phaad2 mariyu suicinate avasaram. swaasakriya ventane aagipotundi mariyu visham chaalaa twaragaa panichestundi, dheeniki etuvanti virugudu ledhu. tatphalitamgaa, ksheeradaalu mfa patla asahanam kaligi untaayi. 
ayithe, konni australian jaatulu (udhaa.zii. brush-tailed posum) glutathione-ess-transferes upayoginchi jeevakriya cheyadam dwara fluoroacetate patla sahanam yokka sthaayini chooputundi. fluoresetate ledhaa fluoresitrate nundi fluoridenu tolaginchavacchu. idhi aaril mariyu alkyl samuuhaalanu glutathione samyogaalugaa marchadam dwara nirvisheekaranalo paalgontundi. carbon yokka nucleophilic daadi kaaranamgaa sii-eff bandham cheelipotundi, phalitamgaa ess-carboxymethyl glutathione erpadutundi. dheenini taruvaata ess-carboxymethylsistine roopamlo visarjinchavacchu.
biotransformed mfa yokka tolagimpu sagam jeevitam sumaru 2 rojulu. icchinappudu, mfa pradhanamgaa rakta plasmalo untundi, conny kaaleyam, moothrapindaalu mariyu kandaraala kanajaalamlo kooda gurtinchavacchu.
vishapuuritam.
mfa anedi oka moorchinche visham. idhi vishapuurita baadhitulaloo teevramaina muurchalaku kaaranamavutundi. swaasa vaiphalyam valla maranam sambhavistundi.
vividha rakaala jantuvulaku, methyl fluoroacetate yokka vishapuuritam noti dwara mariyu subcatanius injection dwara nirnayinchabadindi. motaadu kukkalalo 0.01 mii. graa./kilola nundi kotulalo <ii. dii. 1> mii. graa./kilola varaku untundi, idhi gananeeyamaina vaividhyaanni suuchistumdi. eee jantuvulalo taggutunna grahanaseelata yokka kramam nirnayinchabadindi, avih kukka, ginia-pandhi, pilli, kundelu, meka, taruvaata gurram, eluka, eluka mariyu kothi. eluka mariyu elukalaku, itara jantuvula kante peelchadam dwara vishapuuritam gurinchi puurtigaa parisoedhimchabadimdi. eluka mariyu elukalaku eldi50 450 mii. graa./kyuu.emm. mariyu 1,000 mg kante ekkuva./kyuu.emm. varusaga 5 nimishalu. kukkalu, ginia-pandulu, pillulu, kundellu, mekalu, gurralu, elukalu, elukalu mariyu kotulalo eee padaardham yokka aushadha prabhavalanu noti dwara mariyu injection dwara parisoedhimchaaru. methyl floro acetate anedi swaasakriyaloo pragatiseela maandyaaniki kaaranamavutundi mariyu chaalaa jantuvulalo idhi oka moorchinche visham. charmampai aplai chesinappudu idhi vishapuuritam kaadu, ayinappatikee peelchadam, injection mariyu noti dwara idhi untundi. eluka, pilli mariyu reasus kothi kosam, nikotin, stricknin, leptazole, microtoxin mariyu vidyut prerita muurchala maadirigaane methyl floro acetate prabhavalu nirnayinchabaddaayi. muurcha yokka namuunaa leptazole maadirigaane pariganinchabadutundi. eee jantuvulalo swaasalopam yokka sankethaalu kakunda postmortem kooda kanipinchavu. raktamlo chakkera, haemoglobin, plasma proteins, protein kaani natrajani mariyu seeram potassium, calcium, chloride mariyu akarbana fasfate kosam takkuva sankhyalo kundellu, kukkalu mariyu mekallo anchanaalu cheyabaddaayi. rakta maarpulalo haemoglobin 20 nundi 60 saatam perugudala, raktamlo chakkera 90 saatam varaku peragadam, akarbana phosphates 70 nundi 130% perugudala mariyu protein kaani natrajani mariyu potassiumlo antima perugudalato seeram potassiumlo takkuva gananeeyamaina perugudala unnaayi. leptazole maadirigaane mottam kendra naadii vyavastha methyl floro acetate dwara prabhaavitamavutundi, adhika kendraalu diguva vaati kante ekkuva sunnitamgaa untaayi. methyl floro acetate yokka chinna motaadulu raktapotupai takkuva prabhavanni chuuputaayi, ayinappatikee pedda motaadulalo idhi nikotin maadirigaane charyanu kaligi untundi. idhi swaasakriya yokka raetu mariyu parimaanaanni marinta prerepistundi, aapai swaasakriya vaiphalyaaniki kaaranamavutundi, graphic recordula dwara chuusinatlugaa bahusha muulam kendramgaa untundi. monakaalu mudata charya methyl fluoroacetate dwara uddeepanala vikiranam antha sulabhataram kavadam valla muurchalu vachhe varaku teevrataram cheyabadinatlu kanipistundi. naadii prasarana perugutundi mariyu vennemuka pilli yokka reflexes aarklo pravesha uddeepana taggutundi. methyl floro acetate elukalalo vidyut muurcha parimitini 10 retlu taggistundi. methyl floro acetate oka saktivantamaina muurcha mariyu swaasakosha maandyam rendoo ayinanduna chikitsala ibbandulu nokki cheppabadataayi, ayinappatikee manishilo chikitsa kosam suuchanalu cheyabadataayi. methyl floro acetate elukalu mariyu itara krimulaku vyatiraekamgaa vishamgaa upayoginchina sandarbhamlo aaharam mariyu neeti kalushitamgaa teevramaina pramaadaanni andistundi, endukante idhi sulabhamgaa gurtinchabadadu ledhaa naasanam cheyabadadu mariyu noti dwara mariyu injection dwara samanamga vishapuuritam avutundi.
paryaavarana bahirgatam.
methyl floro acetate utpatti cheyabadutundi mariyu rasayana karakamga upayoginchabadutundi mariyu idhi aneka vyardha pravaahaala dwara paryaavaranaaniki vidudala cheyabadutundi. elukanaasakamgaa upayoginchinappudu, idhi neerugaa vaataavaranaaniki vidudala cheyabadindi, akkada adhi gaalilo vichchinnamavutundi. gaaliloki vidudala cheyabadithe, 25 masim vadda 31 mmhechji aaviri peedanam anchanaa veyadam anedi methyl fluoroacetate vaataavaranamloo aaviriga matrame untundani suuchistumdi. aaviri-dasha methyl floro acetate prakaasa rasayana utpatti hydroxyl radicals thoo praticharya dwara vaataavaranamloo ksheenistundi. gaalilo eee praticharyaku sagam jeevitam 98 rojulu untundani anchanaa. 
mFAloe 290 nm kante ekkuva tarangadairghyamlo grahinche chromophores undavu, anduvalla idhi suuryarashmi dwara pratyaksha photolysisku gurayye avakaasam undadu.
jantuvulapai prabhavam.
jantuvulapai prabhavalu chaalaa vaegamgaa mariyu balamgaa jantuvulapai sambhavistaayi, ivanni maranaaniki daariteestaayi. mfa aaviri adhika saandrataku gurikavadam valla 30-60 nimishala varaku jantuvulalo etuvanti lakshanaalu kanipinchavu. adhyayanala prakaram konni gantallo himsaatmaka praticharyalu mariyu maranam jarigaayi. intravenous injection elukalu, elukalu mariyu ginia pandulu 15 nimishala nundi 2 gantala tarvaata lakshanaalanu chuuputaayi. jantuvulu nissabdamgaa mariyu kungubatuga maarataayi. kundellu idhe vidhamaina gupta kaala vyavadhi mariyu kandaraala balaheenatanu chuuputaayi. kukkalu hyperactivity lakshanaalanu chuuputaayi. jeevakriya yokka adhika raetla kaaranamgaa avi marinta sunnitamgaa untaayi, chivariki, avi swaasa teesukovadamlo kooda viphalamavutaayi. nemmadigaa jeevakriya kaaranamgaa chepalu marinta nirodhakatanu kaligi untaayi, anduvalla eee padaardham chepalalo perugutundani oohinchabadadu. alaage, australian saakaahaarulu (udhaa.zii. fluoroacetate jaadalu unna mokkalatho kuudina aavasalalo nivasinche posum mariyu vittanaalu tine pakshi) kontha sahanam kaligi untaayi. idhi gsh samakshamlo fluoroacetate nirvisheekarana cheyadam dwara ledhaa fluoresitrate kuu aconitase yokka ekkuva nirodhakata dwara jaragavacchu. konni keetakaalu vishanni vaculeslo nilva chesi taruvaata upayoginchavacchu. antekakunda, maanava praanaalaku muppu kaliginchakundaa jantuvulanu vishapuuritam cheyadaaniki atyanta pramaadakaramaina mfani upayoginchalemani gamaninchaali.
antidotal therapy.
mfaku vyatiraekamgaa etuvanti virugudu ledhu, conny mfa vishaprayogam chikitsaku sambandhinchi konni suuchanalu unnaayi. vishaprayogam tarvaata neerugaa vaegamgaa panichese anaesthetics yokka intravenous injectionnu upayoginchaalani salaha istaaru. mattumandu pentothal sodiyam ledhaa evipan sodiyam ayi undaali, taruvaata sodiyam phenobarbitone ledhaa rectal avertain vanti deerghakaalika panichese cartical depressants yokka intramuscular injection undaali. aaa taruvaata, blub mask mariyu krutrima swaasakriyatoe patuga praanavaayuvu sarafaraanu jagrattagaa paryaveekshinchadam avasaram. bahusha, muurcha sthithi vale hypertonic glucosenu siralaloki upayoginchadam avasaram. chivaraga, edainaa muurchalanu niyantrinchadaaniki tubocurine chloridenu jagrattagaa upayoginchaali. edainaa vaantulu sambhaviste, gaali maargam terichi unchadaaniki rogini munduku vanchandi.
pratyamnaayamgaa, fluoresitrate samshlaeshanhanu nivaarinchadam, mitochondria lopala aconitasenu nirodhinchadam mariyu tii. sii. eah. chakranni konasaaginchadaaniki mitochondria nundi citrate pravahanni andinchadam lakshyamgaa oka chikitsa undhi. prastutaaniki, eff. sii. erpadataaniki vyatiraekamgaa ethanol atyanta prabhaavavantamgaa niroopinchabadindi. ethanol aakseekarana chendinappudu, idhi raktamlo acetate sthaayilanu penchutundi, idhi effsy utpattini nirodhistundi. maanavulalo, noti motaadu 40-60 ml 96 saatam ethanol, taruvaata modati gantalo 1.0-1.5 g/kilola 5-10% ethanol sirala dwara mariyu taruvaati 6-8 gantallo 0.01 graamulu/kilola sifaarsu cheyabadindi. eee chikitsa fluoresetate (efae) vishaprayogam kosam uddesinchabadindi, idhi mfaku atyanta sambandhita sammelanam, kabatti mfnu lakshyamgaa chesukunna eee chikitsa itara phalitaalaku daariteeyavachchu.
antekakunda, monoesetin chikitsa phaa vishaprayogaaniki vyatiraekamgaa sahaayapadindi. idhi raktam yokka acetate sthaayilanu penchadamlo sahaayapadutundi mariyu gunde, medadu mariyu moothrapindaalalo citrate sthaayilanu taggistundi. ayithe, idhi prayogaatmakamgaa matrame pareekshinchabadutundi. kotulalo, monoasetin kooda efae yokka prabhavalanu tippikodutundih anni jeeva prabhavalu saadhaaraneekarinchabadataayi.
ethanol maadirigaane, monoasetin efae vishaniki vyatiraekamgaa prabhaavavantamgaa untundi. ippati varaku, mfaku vyatiraekamgaa niroopitamaina chikitsa ledhu. ayithe, mundugaa perkonna chikitsalu mfnu lakshyamgaa chesukuni chikitsaku prarambha sthaanaalanu andinchagalavu, endukante efae mariyu mfa daggari sambandham unna sammelanaalu.

