
tamapin

tamapin anedi bharatiya erra thene ("hatentotta tamulus") nundi vachhe vishapadaartham, idhi sque2 chaanella yokka empika chesina mariyu saktivantamaina blocker.
vyutpatti.
tamapin anedi verucheyabadina teella paeru meeda pettabadindi.
muulaalu.
bharatiya erra thene "hatentotta tamulus" nundi tamapin vaeru cheyabadindi.
rasayana nirmaanam mariyu verucheyadam yokka paddhatulu.
tamapin anedi short-chain scorpion taxin upakutumbam 5kii chendinadi, idhi poe5 mariyu silatoxintho kalisi untundi. apamine yokka bandhinche pradaesamtoe potipade itara vishapadaarthaalatho daani kramam saaruupyata chaalaa takkuvagaa untundi. idhi 31 amaino aamlaala podavu mariyu daani baruvu 3458 daltonlu. dheeni amaino aamlam kramam cys3-cys21, cys8-cys26, mariyu cys12-cys28 (rasayana suutram c146h234n42o42s6) madhya disulfide bandhaalatho kuudina affcnlrcscrslglglgkccigeeeckcvpy. 
sephadex zii-50 saiju exclusion chromatography dwara thene nundi visham yokka apamine-pootii bhaganni gurtinchadam dwara tamapin verucheyabadindi, taruvaata adhika paniteeru gala liquid chromatography (hetch. pii. ell. sii).
tamapin-2 yokka isopharm kanugonabadindi, dheenilo tyrosine histadine dwara bharti cheyabadutundi. sinaptosomlatho bandhinchadaaniki tamapin-2 kooda apaminto chaalaa samarthavantamgaa potipadagaladu.
lakshyam mariyu charya yokka vidhanam.
tamapin yokka lakshyam chinna vaahaka calcium-aadhaarita potassium (ess. keey) chaanal. eee thene vishamu ekkuvagaa tiragagalige paddhatiloo ska 2 verses ska 1 chaanella kosam empikatho ska 2 chaanellanu nirodhistundi. puurtigaa bhinnamaina kramaalu unnappatikee, apamine (theneteega visha visha) mariyu tamapin eluka medadu sinaptosomlapy oke binding saitlanu kaneesam kontha bhaganni panchukuntaayi. clone cheyabadina sque2 binding aselu mariyu saareeraka recordinglalo apaminku atyanta sunnitamainavi. ayithe, tamapin binding pareekshalalo apaaminnu sthaanabhramsham chestundi, anduvalla apaminku sambandhinchi idhi balamaina vishapadaartham. ska 1 mariyu ska 3 adhika saandrata kaligina tapamin thoo matrame prabhaavitamavutaayi, anduvalla eee taxin atyadhika anubandham, ska 3 madhyantara mariyu ska 1 chaanellaku athi takkuva anubandhamtho ska 2 nii nirodhistundi. skaanla madhyavartitva calcium activated potassium chaanal ska4 anedi skaanla madhyavartitvaaniki takkuva daggari sambandham kaligina sabhyudu, dheenini aika1 anie kooda pilustaaru, idhi apaminku sunnitamgaa undadu mariyu tapamin dwara kooda prabhaavitam kaadu. voltage aadhaarita potassium chaanellaku kooda idhe vartistundi; sque2-madhyavartitva pravaahaala block voltage aadhaaritam kaadu. eee nirdishta chaanal block chinna conductains calcium-aadhaarita potassium chhaanals current taggudalanu prerepistundi.
vishapuuritam.
munupati adhyayanalu tamapin prabhavam ekkuvagaa tirigi maarchagaladani mariyu samayam mariyu yekagratapai aadharapadi untundani choopinchaayi. bharatiya erra thene (hatentotta tamulus) etaa mukhyamgaa chinna pillalalo pedda sankhyalo maranaalaku kaaranamavutundi. daani visham adhika vaahakata kaligina calcium activated potassium chaanal yokka atyanta nirdishta blocker ayina iberiotoxin mariyu tamulastoxin vanti atyanta nirdishta potassium chaanal blackerlanu kaligi untundi.

