beata arterivirus suud 1

beata arterivirus suud 1, saadhaaranamgaa porsain reproductive und respiratory syndrome virus (prrsv), anedi pandula vyaadhiki kaaranamayye virus, dheenini porsain reproductive und respiratory syndrome (prrs) anie pilustaaru, dheenini blue-iyar pig vyaadhi anie kooda pilustaaru (chainees bhaashalo, "juu laner bing"). eee aardhikamgaa mukhyamaina, panjutic vyaadhi chinna pandulalo santanotpatti jaathi mariyu swaasakosha vyaadhiloo punarutpatti vaiphalyaaniki kaaranamavutundi.
charitra.
united states mariyu kenadaalo 1987-1988 samayamlo "mystery swine disease" mariyu "blue iyar disease" anie piluvabade PRRs, swaasakosha sanketaalato kalipi punarutpatti nashtaalato kuudina modati nirdhaarana cheyani vyaaptiki kaaranamaindi. 1990-1991 loe, germany, netherlands, belgium, denmark, france, united kingdom mariyu speyin vanti aneka european deshaalalo ilanti vyaadhi nivedinchabadindi. japan, taiwan mariyu chaina pradhana bhoobhagalalo varusaga 1987,1991 mariyu mariyu prrs aavirbhavam nivedinchabadindi.
voh prakaram, eee vyaadhi ippudu prapanchavyaaptamgaa undhi, mukhyamgaa pedda pandhi utpatti unna deshaalalo. australia, newzealand, norway, sweeden mariyu switzerlandlu swatantra deshaalugaa unnaayi.
prrsv yokka janyu vaividhyam yokka merugaina chitram "asalu" vyaaptiki mundu virus aaa praantamloo undani suuchimchimdi. mahammariki mundu praabalyaaniki sambandhinchi namodu cheyabadina dayta lekapovadam anedi prrs gurinchi teliyakapovadam valla jarigindi.
daggari sambandham unna murine lactate dehydrogenase-elevating virus nundi prrsv udbhavinchindani oka parikalpana pratipaadinchabadindi. sumaru 110-140 samvatsaraala kritam russia mariyu belaaraslo virus pratyaekamaina upa janabhaluga vaividhyabharitamgaa maarindani PRRSV epidemiology yokka phylogeographic vislaeshanha suuchimchimdi. ayithe, prsv elaa, eppudu, ekkada udbhavinchindi anae daanipai ippatikee anischiti undhi.
aneka mukhyamaina amsaalu prrsv marinta vistarinchadaaniki anumatinchaayi. 20va sataabdamloo prapanchavyaaptamgaa pandhi parisramalo maarpu keelaka paatra poeshistumdi. adhika saandrata gala nirbandha nirvahana paddhatula aavirbhavam mariyu krutrima garbhadhaarananu avalambinchadam anedi prsv yokka vistruta vistarana mariyu vaividhyeekarananu sulabhataram chesindi. adavi pandulalo prrsv undani cheppadaniki pushkalamaina aadharalu unnaayi. adavi jantuvulu prsv kosam sahaja jalaasayamgaa panicheestaayi mariyu pempudu pandulalo viral infectionlaku adanapu vanarugaa pariganinchavacchu.
prastuta paristhiti.
prrsv swabhaavamlo chaalaa dynamic. perugutunna janyu vaividhyam teevramaina vyaapti yokka aavirbhaavaaniki veelu kalpistundi, idhi perigina garbhasravam raetu alaage perugutunna pandulu mariyu aavulalo maranaala dwara vargeekarinchabadutundi. idhi 1996,2000 mariyu mariyu americalo mariyu mariyu chainaalo jarigindi. atyanta vyadhikaaraka mariyu vishapuurita "asaadhaarana" praarsvi isolatelu vividha european deshaalalo kramam tappakunda nivedinchabadutunnaayih bellarus, belgium, hangari, austria mariyu itarulu. rendu prsv janyuroopaalato tayaaru chesina ksheeninchina teekaalatho prapanchavyaaptamgaa swine mandala roganirodhakata karyakramalu karyakramalu praarambhamlo aasaajanaka phalitaalanu andinchaayi.
prastutam prrs, swine parisramanu prabhaavitam chese atyanta mukhyamaina antu vyaadhulalo okati. pramaadavasaattu jaatula marpidi prasaram mariyu prapanchavyaaptamgaa pandhi utpattilo gananeeyamaina aardhika nashtaala dwara udbhavinchinanduku dheeniki "pandhi sahayakalu" anie kooda paeru pettaru.
virology.
vargeekarana.
prrsv anedi "artiriviridae" kutumbaaniki chendinadi, mariyu "nedovirals" anie piluvabadutundi. arterviridae" kutumbaaniki chendina itara sabhyulalo eekwin arterities virus (eee. eah. vii), simean hemorrhagic feavour virus (ess hetch. eff. vii), wobley posum disease virus mariyu lactate dehydrogenase elevating virus (eldivi) unnaayi.
nirmaanam mariyu janyuvu.
prrsv anedi oka chinna, oke-stranded, positive-sense, enveloped rna virus. 15 kebi janyuvulo 5 'anuvaadam cheyani praantam (utr), padhi open reeding framelu (rfs (rfs mariyu mariyu taruvaata polyadenylation thokatho kuudina oka sarala, oke chikkukunna rna anuvu untundi.
rendu pedda rfs (1eah mariyu mariyu viral janyuvulo 75 saatam kaligi untaayi. avi naalugu proteages mariyu rna-aadhaarita rna paalimaresto sahaa 14 nirmaanaatmaka kaani proteins anuvadinchabadi proses cheyabadataayi.
oka prrsv kanamlo rfs 2-7 dwara encode cheyabadina enimidi viral structural proteins untaayi. avi envalap proteins proteins, ii, ii, jipi3, jipi4, jipi5 mariyu emm) mariyu nucleocapsid (enn) protein kaligi untaayi. artiriviridae" mariyu prrsv yokka mottam kutumbamlo atyanta samrakshinchabadina proteins, mukhyamgaa, mukhyamgaa (rna-aadhaarita rna polymerase) mariyu nucleocopsid (enn) protein. saaruupyata vislaeshanha anedi anedi mariyu mariyu hyper-variable praantaala unikini pradarsistundi.
oka sameekarinchabadina prsv virian 56 nm sagatu vyaasam kaligina golaakaara kanamgaa kanipistundi. kanaalu rendu pradhana envalap protein complexelu m-gp5 mariyu gp2-gp3-gp4 dwara suchinchabade konni poduchukunna lakshanaalatoo envalap yokka lipid dvipadaram yokka chaalaa mruduvaina roopurekhalanu pradarsistaayi. eee complexelu varusaga baga vargeekarinchabadina grahakaalu cd169 (sialodhesin) mariyu cd163 thoo sankarshana chendutaayi.
janyu vaividhyam.
praarsvi rendu pradhana rakaluga upavibhajana cheyabadindi, european (type 1 anie kooda pilustaaru) mariyu uttara america (type 2 anie kooda pilustaaru). prati prrsv rakaniki namuunaa shrenulu nirvachinchabaddaayi. european prsv kosam, idhi lelistad virus (elvi), ayithe uttara america prsv kosam, idhi vr-2332. european mariyu uttara america prsv jaatulu saaruupya clinical lakshanaalanu kaligistaayi, conny rendu vibhina viral janyuroopaalanu suuchistaayi, veeti janyuvulu sumaru 40 saatam vaerugaa untaayi, tadwara eee virus muulam gurinchi rahasyamaina musugunu srushtistaayi. eee suduura rakaalaina prsv aavirbhavam rendu swatantra parinaamaatmaka sanghatanala phalitamgaa jarigindani soochinchabadindi. rakam 1 mariyu rakam 2 prrsv yokka spashtamaina vyatyaasaaniki anugunamgaa, avi rendu ververu vairaslugaa vibhajinchabaddaayi.
vividha pradaesaala nundi verucheyabadina vairasla madhya janyu vaividhyam daaniki vyatiraekamgaa teekaalanu abhivruddhi cheyadamlo kashtanni penchutundi. adevidhamgaa, eee virus yokka adhika utparivartana raetu kaaranamgaa roganirdhaarana pii. sii. aarr. gurtimpu madimpulanu nirvahinchadam kashtam.
airopalo, diguva (paschima mariyu madhya airopa) mariyu adhika (thoorpu airopa) airopa) vaividhyam madhya bhougolika sarihaddu undhi. open reeding frame (orf) 7 parimaanam aadhaaramgaa prastuta janyu vargeekarana kaani jaatulalo moodu ververu uparakaalu unnayani velladinchindihi uparakam 1, namoonaga lelistad virus thoo, airopa mariyu russialo, uparakam 2 russia mariyu lithuvenialo mariyu uparakam 3 belaaraslo unnaayi. telisina uparakaalato paatu, iteevali adhyayanam uparakam kaani kaani isolatelanu choopinchindi.
prasaram.
prrsv prasaram yokka namuunaa pradhanamgaa contact mariyu airbourne dwara untundi. prrsv prasaram anedi bahirgatam ayye maargam, virus isolate mariyu virus motaadu meeda ekkuvagaa aadharapadi untundi.
intranasal, intramuscular, peroral, intravatorine mariyu yoni vanti aneka maargaala dwara pandulaku prrs virus sokavachani choopabadindi. pandulu intramuscular teaca (50 saatam end point (tii. sii. ii. dii. 50) thoo tissue culture antu motaadu), taruvaata intranasal maargam (<ii. dii. 1> tii. sii. ii. dii. 50) mariyu peroral maargam (<ii. dii. 2> tii. sii. ii. dii. 50) dwara sankramanaku ekkuvagaa guravutaayi.
antu prsv yokka sagam-jeevitakaalampai sthiramgaa) ushnograta goppa prabhavanni chooputundani kanugonabadindi. virus vaedi cheyadam, endabettadam ledhaa teevrataramaina pihech dwara twaragaa nishkriyam cheyabadutundi. aerosolized prsv 41°sii vadda athi takkuva sthiramgaa sthiramgaa = 3.6 nimisham) mariyu 73.0% saapeksha aardrata mariyu 5°sii vadda atyanta sthiramgaa sthiramgaa = 192.7 nimisham) mariyu 17.1% saapeksha aardrata kaligi undani prayogaalu choopinchaayi.
rakam 1 prsv kosam praathamika punarutpatti sankhya sankhya amayaka pandulalo sumaru 2 nundi 5 varaku untundi. rakam 1 prrsv isolatelatho poliste, rakam 2 prrsv jaatulu adhika virus kaligi unnatlu pariganinchabadataayi.
vyadhikaaraka.
pempudu pandulu mariyu itara "suiday" matrame praarsvi yokka sahaja atidheyulu. pii. aarr. aarr. la yokka vilakshanhamaina clinical lakshanaalalo pigletlalo swaasakosha vyaadhi mariyu aavulalo punarutpatti vaiphalyam unnaayi.
monocyte/macrophage vamsaaniki chendina kanaalu (oopiritittulu, shosharasa kanupulu, pleehamu, maavi mariyu itara avayavaalalo macrophaselu, dendritic kanaalu) "inn vivo" viral replicationku praathamika lakshyalu. pratiruupana chakram anedi PRRSV yokka GP5-M complexes mariyu cellular grahakaalu heparon sulfate mariyu cd169 (sialodhesin) madhya paraspara charyatho praarambhamavutundi. bandham mariyu antargateekarana taruvaata, gp2-gp3-gp4 nucleocopsid yokka vibhajana mariyu vidudalaku madhyavartitvam chestu cd163 thoo sankarshana chendutundi.
prrsv sankramana teevramaina sankramanatho praarambhamavutundi, eee samayamlo tansils mariyu oopiritittulu sankramanaku praadhaanyata pradaesaalugaa panicheestaayi, idhi chinna pandulalo swaasakosha samasyalaku daariteestundi. sankramana yokka modati dasha sankramana tarvaata 6-12 h nundi praarambhamayye kana rahita viramiacu daariteestundi mariyu prasarana pratirakshakaalu prerana ayinappatikee aneka vaaraala paatu konasaagutundi. tadanantaram, pandula roganirodhaka sthithini batti, tansils, pleehamu mariyu shosharasa kanupulato sahaa shosharasa avayavaalalo viral replication thoo nirantara dasato teevramaina sankramana konasaagavacchu. sankramana chivari dasalo, host loe virus tolaginchabade varaku prrsv replication kramamga taggutundi. ayithe, virus pandulalo ekkuva kaalam konasaagavacchu. pattudala yokka vidhanam host roganirodhaka nigha nundi tappinchukovadaaniki veelu kalpinche prsv rna janyuvu yokka adhika utparivartana raetu meeda aadharapadi undavacchu.
vistrutamaina viramia taruvaata, virus vividha antargata avayavaalalo macrophaselaku cherukuntundi (udhaa.zii. shosharasa kanajaalaalu mariyu talli endometrium) phalitamgaa aavulalo punarutpatti vaiphalyam vanti rugmatalu erpadataayi. garbhadhaarana chivari dasalo, prrsv garbhanirodhaka addankini daati pindaalaki sokutundi. viral strain mariyu host yokka roganirodhaka sthithini batti, prrsv subclinical mariyu teevramaina punarutpatti mariyu/ledhaa swaasakosha vyaadhi rendintikee kaaranam kaavacchu. prrsv atitheya roganirodhaka rakshana vyavasthanu anachiveyagaladu, idhi dviteeya antuvyaadhulanu sthaapinchadaaniki anumatistundi.
itara vyadhikaaraka kaarakaalato saha-sankramanala dwara prrsv sankramana yokka clinical phalitaanni teevrataram cheyavachu. idhi perugudala panitiirutoe samasyalu mariyu jwaram, daggu, anorexia mariyu dyspnia vanti clinical sanketaalato vargeekarinchabadutundi. prsv thoo paatu, porsain circovirus rakam 2 2, "pasteurella multicida" mariyu porsain mycoplasmalu porsain swaasakosha vyaadhi sanklishta prabhaavita pandulalo tarachugaa kanugonabadina vyadhikaarakaalu. prrsv sankramana pandulalo upayoginche teekaala saamarthyaanni kooda tagginchavachhu. eee samasyala kaaranamgaa, prrs prapanchavyaaptamgaa pandhi parisramaku teevramaina muppuga pariganinchabadutundi.
adhika vyaadhikaarakata" anae padam yokka hodha saapekshamgaa untundi. saadhaaranamgaa, atyanta vyadhikaaraka prr garbhinii aavulalo adhika punarutpatti vaiphalyam raetu, adhika anaarogyata mariyu anni vayasula pandulalo adhika maranaalanu chooputundi. vyaadhi sokina pandulu swaasakosha (dyspnia, tummu, daggu) mariyu daihika clinical sankethaalu (+ 41 masim kante ekkuva deerghakaalika adhika jwaram, niraasa, anorexia, charmam mariyu chevula rangu maaradam), kandlakalakanu pradarsistaayi. konni sandarbhaallo naraala sankethaalu kanipistaayi. necropsy vadda saadhaarana gayalalo oopiritittulu mariyu shosharasa kanupula vaapu, fibrinus pleuro pneumonia mariyu pericardities, peritonitis undavacchu.
niyantrana.
prayogasaala roganirdhaarana.
1980la chivaralo prrs vairasnu praarambhamlo kanugonnappati nundi prayogasaala aadhaarita roganirdhaarana pareekshalu gananeeyamgaa abhivruddhi chendaayi. seeram ledhaa kanajaala namoonaalalo prrsvni nirdhaarinchadaaniki praarambhamlo viral culture upayoginchabadindi. eee prakriyaloo virus inn-vitronu sell linelalo 3-14 rojulu ledhaa anthakante ekkuva kaalam paatu penchadam untundi. culture samayamlo cytopathic prabhavam gamaninchinatlayithe, namuunaanu prrsv unikiki sanukoolamgaa nivedinchadaaniki mundu pratyaksha fluorescent antibody ledhaa itara nirdhaarana paddhati dwara culture prrs vairasga nirdhaarinchabadutundi.
1990la chivaralo, nested pcr vairasnu gurtinchadaaniki upayoginchabadindi, endukante idhi nested kaani pcrpy merugaina sunnitatvaanni choopinchindi. ippudu, parimaanaatmaka pcr vislaeshanhalu nested pcr kante manchi ledhaa merugaina sunnitatvam, prayogasaalalo vegavantamaina turneround samayam mariyu closed-tube amplification dwara cross-kalushyam yokka takkuva retlanu andinchaayi.
prrlanu niyantrinchadaaniki nirvahana vyuuhaalu.
prsv nii niyantrinchadaaniki mariyu tolaginchadaaniki vividha nirvahana vyuuhaalu pratipaadinchabaddaayih
jantuvulaku roganirodhaka shakti.
churukaina roganirodhakata prastutam prapanchavyaaptamgaa swine mandalalo prrs niyantranaku vistrutamgaa andubaatulo unna ekaika maargam. jantuvulaku nirdishta roganirodhakata kosam, aneka rakaala teekaalu mariyu pratyaksha virus teekaalu upayoginchabadataayi.
modati modati pratyaksha teaca, ingelwack prrs mlv (bohringer ingelheim vetmedica, ink.), 1994 nundi prr la nivaarana mariyu niyantrana kosam andubaatulo undhi. idhi maark-145 kanaalalo nirantara maargaala dwara pondabadindi. eee roeju varaku, aneka vaanijyaparamaina prrs teekaalu prapancha marketlo vijayavantamgaa upayoginchabaddaayi. praarsvi yokka goppa janyu vaividhyam mariyu rakshanatho sambandham unna spashtamaina roganirodhaka paaraamitulu lekapovadam kotta prorse teaca abhivruddhiki gananeeyamaina addamkulu.
praarsku nirodhakata kaligina pandulanu janyu savarana saanketika parignaanaanni upayoginchi biotechnology company genus roopondinchindi.

