
naadii kanaala samslaeshanha anuvu

naadii kanaala samslaeshanha anuvu (enn. keey. emm), dheenini sidi56 anie kooda pilustaaru, idhi neuronlu, glia mariyu asthipanjara kandaraala uparitalampai vyakteekarinchabadina homophilic binding glycoprotein. daani aavishkarana sait kaaranamgaa sidi56 tarachugaa naadii vamsa nibaddhataku chihnamgaa pariganhinchabadinappatiki, sidi56 vyakteekarana itarulatoe paatu, hematopoietic vyavasthalo kooda kanipistundi. ikkada, cd56 yokka vyakteekarana ekkuvagaa sahaja killer kanaalatoe mudipadi untundi, conny veetike parimitam kaadu. gaama delta (γδ) τ kanaalu mariyu sakriyam cheyabadina cd8 + t kanaalatoe paatu dendritic kanaalatoe sahaa itara shosharasa kanaalapai cd56 kanugonabadindi. kana-kana samslaeshanha, neurite perugudala, synaptic plasticity mariyu abhyasam mariyu ghnaapakasaktiloo enn. keey. emm paatra undani soochinchabadindi.
roopaalu, domainlu mariyu homophilic binding.
enn. keey. emm. anedi immunoglobulin (aiji) suupar famileaki chendina glycoprotein.
kaneesam 27 pratyamnaayamgaa spliesed enn. keey. emm. emm. aarr. enn. utpatti cheyabadataayi, ivi enn. keey. emm. isopharmla yokka vistruta vaividhyaanni andistaayi. enn. keey. emm. yokka moodu pradhana isopharmlu vaati cytoplasmic domainlo matrame maarutuu untayih 
enn. keey. emm. yokka extracellular domainlo aidu immunoglobulin lanty (aiji) domainlu untaayi, taruvaata rendu fibronectin rakam III (fnii) domainlu untaayi. aiji domainlu enkaamtho homophilic binding loe palgontunnayi, mariyu fnii domainlu neurite perugudalaku daariteese signalingnu kaligi untaayi, enn com yokka vividha domainlu ververu paatralanu kaligi unnayani choopabadindi.
vyatiraeka uparitalaalapai ("trans-") enn. keey. emm. anuvulu mariyu oke uparitalampai ("sis-") enn. keey. emm. anuvula madhya homophilic binding jarugutundi. enn. keey. emm. homophilic binding trans-mariyu "sis-" rendintiloonuu elaa sarigga amarchabadindane daanipai chaalaa vivaadam undhi. prastuta namuunaalu aidu aiji domainla madhya ledhaa kevalam igi mariyu igi madhya samaantaramgaa bandhinche rendu enn com anuvula madhya "trans-" homophilic binding sambhavistundani suuchistunnaayi. "sis-" homophilic binding anedi igi mariyu igi, mariyu igi mariyu igi rendinti madhya paraspara charyala dwara sambhavistundani bhaavistaaru, idhi adhika arder encom multimernu yerparustundi. neurite perugudalaku daariteese enn. keey. emm. "activation" loe "sis-" mariyu "trans-enn. keey. emm. homophilic binding" rendoo mukhyamainaviga chuupabaddaayi.
chinna exans.
enn. keey. emm. transcript loe itara "chinna" exanlanu choppinchadam dwara sanklishtata yokka maroka pora srushtinchabadutundi. atyanta mukhyamainavi renduh
anuvaadaanantara savarana.
aidava aiji domainku polycial aamlam (psa) nuu jodinchadam dwara anuvaadaanantaramgaa savarinchagalagatam valla enn. keey. emm. glycopharmlanu pradarsistundi, idhi daani homophilic binding lakshanaalanu raddu chestundani mariyu kana valasa mariyu dandayaatralo mukhyamaina kana samshlaeshanhanu tagginchadaaniki daariteestundani bhaavistunnaaru. abhyasam mariyu ghnaapakasaktiloo psa keelakamainadigaa choopabadindi. endoneuraminidase (endon) enjaim dwara enn. keey. emm. nundi pii. ess. yea. nuu tolaginchadam deerghakaalika potentiation (eltipi) mariyu deerghakaalika depression (ltiti) nuu raddu chestundani choopabadindi.
saadhaarana kanaalalo vyakteekarana.
neural sell addession molecule enn. keey. emm. 1 prarambha pinda kanaalapai kanipistundi mariyu marphogenesis pradaesaalaloo kana samuuhaalu mariyu vaati sarihaddula erpaatulo mukhyamainadi.
taruvaata abhivruddhilo, enn. keey. emm. 1 (sii. dii. 56) vyakteekarana vividha vibhina kanajaalaalapai kanipistundi mariyu idhi neuronla madhya mariyu neuronlu mariyu kandaraala madhya madhyavartitvam chese pradhana keey. emm. antukune prakriya.
function.
enn. keey. emm. fibroblast groth phyaaktar receptor (eff. zii. eff. aarr) dwara neurite perugudalanu prerepistundani mariyu pii59fine signalling maargampai panichestundani bhaavistaaru.
naraalalo, enn. keey. emm. 1 neuronla madhya mariyu neuronlu mariyu kandaraala madhya homophilic (lanty) paraspara charyalanu niyantristundi; idhi fibroblast groth phyaaktar receptor (eff. zii. eff. aarr) thoo anubandhistundi mariyu neurite perugudalanu prerepinchadaaniki receptor yokka tyrosine kines charyanu prerepistundi. neural crest kanaalu enn-com mariyu enn-caderine tayaareeni aapi, integrin grahakalanu pradarsinchadam praarambhinchinappudu, kanaalu vidipoyi valasapothayi.
hematopoisis samayamlo, sidi56 anedi enn. keey. kanaala prototypic marker, idhi sidi4 + tii kanaalu mariyu sidi8 + tii kanaala upasamitilo kooda untundi.
kanaala samshlaeshanhaloo, cd56 pindam abhivruddhi samayamlo kana-kanaala samslaeshanha ledhaa kana-maatrika samshlaeshanhaku dohadam chestundi.
pathology.
anatomic pathologylo, pathologistlu konni kanitulanu gurtinchadaaniki sidi56 immunohystochemistry upayogistaaru. 
cancer.
enn. keey. emm. suupar familylo oka sabhyudu, enn. keey. emm. 2 janyuvu vividha sthaayilalo garbhasaya garbhasaya prenoplastic gaayaala nundi utpannamaina maanava papillomavirus-positive neoplastic caratinocyteslo kramamga tagginchabadatam gamaninchabadindi. eee kaaranamgaa, enn. keey. emm. 2 tumerigenesisto mudipadi unde avakaasam undhi mariyu garbhasaya garbhasaya prenoplastic gaayaala purogatiki sambhaavya rooga niruupana marker kaavacchu. 
algimers vyaadhi.
algimers vyaadhi baadhitula hippocompal synapses loe takkuva sthaayilo enn. keey. emm. 2 kanipistundi mariyu beata-amyloid dwara vichchinnam cheyabadindani kanugonabadindi.
rabis.
rabis virus kosam lakshya proteinlalo okatigaa enn. keey. emm gurtinchabadindi, idhi kanamloki pravesinchadaaniki veelu kalpistundi.
anty-enn. keey. emm therapy.
prayogaatmaka antibody aadhaarita immunotherapy kosam enn. keey. emm. nii lakshya anuvugaa upayoginchaaru. neuroblastoma unna pillalaku enn. keey. emm-binding 123zhe-yuje13eah ledhaa 131zhe-yuje13eah radeo-immunoconjugates injections icchina taruvaata metastases yokka vijayavantamaina radeo-immunolocalisation pradarsinchabadindi. chinna kana oopiritittula cancer unna rogulaku rendu ververu clinical adhyayanaalalo anty-enn. keey. emm. immunotaxin hunn901-dii. emm. 1 thoo chikitsa andinchaaru, idhi aamodayogyamaina vishapuuritatvaanni mariyu clinical pratispandana sankethaalanu velladistundi.

