
lobaplatin

lobaplatin anedi chinna kana oopiritittula cancer, operation cheyaleni metastatic rommu cancer mariyu deerghakaalika milogenous leukemia chikitsa kosam chainaalo pratyaekamgaa aamodinchabadina platinum aadhaarita antinoplastic metalodrug. eee aushadham sysplatine yokka moodava taram analog, idhi prapanchavyaaptamgaa aamodinchabadina mariyu vistrutamgaa upayoginche platinum aadhaarita cancer nirodhaka aushadham.
lobaplatin yokka pharmacodynamics adhyayanalu sysplatine mariyu carboplatin kante ekkuva cancer vyatiraeka charya mariyu takkuva vishapuuritatanu kanugonnayi mariyu sysplatine-nirodhaka cancer kanaalaku vyatiraekamgaa charyanu choopinchaayi. ayithe, lobaplatin yokka prapancha aamodam samarthatha yokka parimita aadhaaraala kaaranamgaa parimitam cheyabadindi.
nirmaanam.
lobaplatin (1,2-diamino-methyl-cyclobutane-platinum (ii) lactate) yokka nirmaanamloo platinum (ii) loha kendram, bidentate amine ligand (1,2-bis (aminomethyl) cyclobutane) mariyu lactic assid vadilivese samuuhamtoe samanvayam cheyabadi untundi. lobaplatin bolus injection ledhaa infusion dwara siralaloki ivvabadutundi mariyu rendu diasterioisomerlu, r, r, s-mariyu s, s, s-aakruteekaranala yokka sumaru 50/50 mishramtho koodi untundi.
charya yokka yantraangam.
lobaplatin kosam antineoplastic charya yokka vidhanam chaalaa vivaramgaa adhyayanam cheyabadaledu. prastuta yaantrika adhyayanala phalitaalu lobaplatin anedi antinoplastic agentnu anusandhaaninche dna cross anie mariyu itara plattin metalodraglatho (i.ii., sysplatine mariyu oxalyplatin).
lobaplatin oka anukuula aushadhamgaa panichestundi, idhi sareeramlo hydrolyse cheyabadi, dnatho sankarshana chendagala kriyaaseela roopaanni yerparustundi. pratyaekamgaa, lobaplatin hydrolyse ayinappudu lactate ligand protonate cheyabadi lactic yasidga vidipotundi, idhi chaarj cheyabadina mariyu atyanta reactive platinum complexenu yerparustundi, idhi DNA bays yokka n-donorlatho samanvayam chestundi mariyu DNA samshlaeshanhanu nirodhistundi. daani reactive (kriyaaseela) roopamlo, platinum loha kendram rendu prakkane unna gwanin-gwanin (jiji) ledhaa rendu gwanin-adenine (gaa) bessto inter-mariyu intra-strand cross-linkla dwara dna-jodimpulanu yerparustundi, idhi apoptosisnu prerepistundi mariyu kana perugudalanu nirodhistundi. lobaplatin apoptosis mariyu kana vistaranatoe sambandham unna sii-mike janyuvu yokka vyakteekarananu prabhaavitam chestundani choopabadindi.
vishapuuritam mariyu dushprabhaavaalu.
platinum aadhaarita aushadhaala vishapuuritam anedi vadilivese samuuham (luu) entha sulabhamgaa jalavisleshanam cheyabadutundane daanipai ekkuvagaa aadharapadi untundi, sulabhamgaa vidipoye samuuhaalu sulabhamgaa vidadeeyani marinta sthiramaina vadilivese samuuhaala kante gananeeyamgaa ekkuva vishapuuritamainavi. lactic assid leaving group yokka manchi sthirathvam kaaranamgaa, lobaplatin marinta sthiramgaa untundi mariyu anduvalla modati mariyu rendava taram platinum aadhaarita aushadhaala kante takkuva vishapuuritam.
bahula clinical trialslo lobaplatin yokka vishapuuritam sarvasaadhaaranam, 3 nundi 4 vaaraalaku 60 mg/m2 (shareera uparitala vaisaalyam) garishtamgaa thattukogala motaadu mariyu motaadu-parimitam chese vishapuuritam thrombocytopenia. saadhaarana dushprabhavalalo agranulocytosis, thrombocytopenia, raktaheenata, leukopenia, vikaram mariyu vaantulu unnaayi.
charitra.
1990loe germanyloni austa forma dwara dii-1966 anae parisoedhanaa paerutoe lobaplatin mottamodata samslaeshanha cheyabadi abhivruddhi cheyabadindi. austa forma dwara lobaplatin abhivruddhini nilipiveyadam gentaris ag (eterna prayogasaalalu) dwara aushadham yokka marinta abhivruddhiki daariteesindi. 2003loe, gentaris ag chainaalo lobaplatin tayari mariyu marketing kosam hainan tianwang international pharmaceutical thoo oppandam kudurchukundi. chaina phud und drugg administration prakaram, 2010loe, chainaalo clinical upayogam kosam lobaplatin aamodinchabadindi.