
phenylthiocarbomide

phenylthiocarbomide (pii. tii. sii), dheenini phenylthioria (pii. tii. yuu) anie kooda pilustaaru, idhi phenyl valayanni kaligi unna organosulfur theoria.
ruchi yokka janyu alankarananu batti idhi chaalaa chedhu ruchini kaligi untundi ledhaa vaastavamgaa ruchi laeni asaadhaarana lakshanaanni kaligi untundi. eee lakshanam yokka vaarasatvam mariyu vyakteekarana kontha klishtamgaa unnappatikee, pii. tii. sii. ruchini ruchi chuse saamarthyaanni tarachugaa prabalamaina janyu lakshanamgaa pariganistaaru.
pitisi melanogenesisnu kooda nirodhistundi mariyu paaradarsaka chepalanu penchadaaniki upayogistaaru.
70 saatam mandhi prajalu pii. tii. sii ruchini ruchi chudagalaru, idhi nyuu ginia yokka swadeshi australianlu mariyu swadeshi prajalaku 58 saatam nundi americaloni swadeshi prajalaku 98 saatam varaku untundi. dhumapanam cheyani vaaru mariyu coffey ledhaa tii alavaatu laeni vaaru saadhaarana janabha kante ganankaparamga ekkuva saatam ruchini kaligi unnaarani oka adhyayanam kanugondi. aahaaramlo pii. tii. sii. sambhavinchadu, conny sambandhita rasayanalu sambhavistaayi, mariyu aahara empika anedi pii. tii. sii. ruchi chuse vyakti yokka saamardhyaaniki sambandhinchinadi.
charitra.
1931loe dupant rasayana shaastravetta orther faaks anukokunda suukshma spatikaakaara pitisi meghanni vidudala chesinappudu pitisi yokka pareekshinchina janyu ruchi drugvishayam kanugonabadindi. sameepamloni sahodyogi chedhu ruchi gurinchi firyadu cheyagaa, daggaragaa undi, balamaina motaadu pondaalsina nakka aemee ruchi chudaledu. nakka appudu vividha kutumbaalu mariyu snehitula ruchi moggalanu pareekshinchadam konasaaginchindi, bhavishyat janyu adhyayanalaku punaadi vesindi. janyu vyaapti entha balamgaa undho, idhi dna matching raakamundu pitrutva pareekshalalo upayoginchabadindi.
maanava janabhalo mendelian polymorphisionku udaaharanagaa paatasaala mariyu kalaasaala aacharanaatmaka bodhanalo pitisi ruchi pareeksha vistrutamgaa upayoginchabadindi. ruchi pareeksha aadhaaramgaa, saadhaaranamgaa pii. tii. sii. loe naanabettina kaagitam mukka (ledhaa takkuva vishapuuritamaina propyltheuracil (prope)) aadhaaramgaa, vidyaarthulanu ruchigala mariyu ruchi laeni samuhaluga vibhajistaaru. oke autosomal janyuvu vadda oka aadhipatya yugmavikalpam dwara pitisi ruchi nirnayinchabadutundani, mariyu taragati anedi hardy-weinberg samathoulyamlo unna janabha nundi nishpaakshikamaina namuunaa anie bhaavinchadam dwara, vidyaarthulu pedda janabhalo yugmavikalpam mariyu janyuroopa pounahpunyaalanu anchanaa vaestaaru. eee vivarana eee lakshanam yokka aneka adhyayanaalatho vistrutamgaa sthiramgaa unnappatikee, itara janyuvulu, lingam, vayassu mariyu paryaavarana karakalu pitisiki sunnitatvaanni prabhaavitam chestayani gamaninchaali. alaage, mukhyamgaa african janabhalo, pitisi ruchini nirnayinche pradhana janyuvu vadda vaeru cheyabadina aneka yugmavikalpalu unnaayi, mariyu saadhaarana "ruchigala" yugmavikalpam asampuurnamgaa prabalamgaa untundi (eee yugmavikalpam kosam homojaigotlu heterozygotela kante pitisiki marinta sunnitamgaa untaayi). adanamgaa, pitisi vishapuuritamainadi mariyu pratyaamnaaya, prope patla sunnitatvam, pitisini ruchi chuse janyu niyantrana saamardhyamtho balamaina anubandhaanni choopinchadu.
ruchilo paatra.
theoria sammelanaalu mariyu aaharapu alavaatlanu ruchi chuse saamarthyaanni anusandhaaninche pedda aadharalu unnaayi. eee paniloo ekkuva bhaagam 6-propyl-2-theoracyl (prope) paie drushti saarinchindi, idhi takkuva vishapuuritatanu kaligi unna pitisiki sambandhinchina sammelanam. supertasterku pii. tii. sii. ruchi chuse saamarthyam ekkuvagaa untundi. marovaipu, bhaarii sigaret dhumapanam chesevaariki adhika pitisi mariyu prope parimitulu unde avakaasam undhi (antey.ii. avi saapekshamgaa sunnitatvam laenivi).
1976loe, pii. tii. sii. kii ruchi sthithi mariyu chettu yokka "antidesma bunius" panduloo chedhu bhaagam madhya viloma sambandham kanugonabadindi. prabhavalapai parisoedhana inca konasagutondi.
pii. tii. sii ruchini ruchi chuse saamarthyam bahusha rasayana saaruupyatala kaaranamgaa "brassica" jaatilooni mokkala patla ayishtatatho sambandham kaligi undavacchu. ayithe, aafrikaalo adhyayanalu pii. tii. sii ruchi mariyu aahara vyatyaasaala madhya paelavamaina sambandhaanni chuupistunnaayi.
janyusaastram.
pitisi ruchi loe chaalaa vaividhyam taas2aarr38 ruchi grahaka janyuvu vadda polymorphismtho mudipadi untundi. maanavulalo, janyuvu venta moodu Snps (single nucleotide polymorphisms) unnaayi, ivi daani proteinlanu pratispandinchanivigaa chestaayi. eee lakshanam yokka vaarasatvam aadhipatyam kaligi undaa ledhaa asampuurnamgaa aadhipatyam kaligi undaa anedaaniki viruddhamaina aadharalu unnaayi. eee janyuvu yokka oke kriyaatmaka coppy unna yea vyakti ayina proteinnu tayaaru cheyagaladu mariyu pitisiki sunnitamgaa untaadu. konni adhyayanalu bhinnamaina vaati kante sajatiya ruchulu marinta teevramaina chedunu anubhavistaayani choopinchaayi; itara adhyayanalu maroka janyuvu ruchi sunnitatvaanni nirnayinchavacchani suuchimchaayi.
vividha maanava janabhalo pitisi taster mariyu naan-taster yugmavikalpala tarachudanam maarutuu untundi. aneka vivikta janabhalo, janyu vyaadhini andinche tirogamana yugmavikalpala kante chaalaa saadhaaranamaina, madhyantara pounahpunyaala vadda ruchi laeni yugmavikalpala vistrutamaina uniki, eee bahuroopata samatulya empika dwara nirvahinchabadutundani suuchistumdi.
chimpanjilu mariyu orangutanlu kooda maanavulalo maadirigaane ruchulu mariyu ruchileni vaati nishpattitoe, pii. tii. sii ruchi chuse saamardhyamlo maarutuu untaayi. pitisini ruchi chuse saamarthyam anedi hominidla yokka puurveekula lakshanam, idhi maanavulu mariyu chimpanjeelalo swatantramgaa, taas2aarr38 vadda vibhina utparivartanala dwara kolpoyindi.

