protofection

protofection anedi ippatike unna sthaanika mitochondrial dnaku anubandhamgaa ledhaa bharti cheyadaaniki kanajaalamloni kanaala mitochondrialoki videshee mitochondrial dna (mtdna) yokka protein-madhyavartitva badilee. polymerase golusu praticharya dwara utpatti cheyabadina puurti mtdna janyuvu ledhaa mtdna sakalaalanu eee saanketikata dwara lakshya mitochondrialoki badilee cheyavachu. 
mitochondrial vyaadhulu unna rogulaku protofection prayojanakaramgaa untundani saastravettalu gatha rendu dasabdaluga oohinchaaru. eee saanketikata iteevali abhivruddhi mariyu nirantaram merugupadutondi. mitochondrial dna vayassutho kramamga marinta debbatinnanduna, idhi paatha kanajaalamlo kaneesam paakshikamgaa punarujjeevimpajese mitochondria paddhatini andinchi, vaatini vaati asalu, yavvana paniteeruku punaruddharinchavachhu.
paddhati.
protofection anedi abhivruddhi chendutunna saanketikata mariyu nirantaram merugupadutondi. mtdnatho sanklishtamgaa unde oka nirdishta protein transduction vyavastha srushtinchabadindi, idhi mtdnnu lakshya kana pora antataa kadaladaaniki mariyu pratyaekamgaa mitochondrianu lakshyamgaa chesukovadaniki veelu kalpistundi. upayoginche transduction vyavasthalo protein transduction domine, mitochondrial localization sequencelu mariyu mitochondrial transcription phyaaktar a untaayi. veetilo prati okkati protofectionlo nirdishta paatra poeshistaayih
eee prakriya lakshya kanaala mitochondrialo unna mtdna parimaanamlo perugudalaku daariteestundi.
protofection modati upayogam nundi, transduction vyavastha sardubaatu cheyabadindi mariyu savarinchabadindi. gatamlo pitidi-mls-tfam complexes anie piluvabade eee complexes paerunu tagginchadaaniki, ippudu dheeniki entidi-tfam anie paeru pettaru. entidi antey mitochondrial transduction domine mariyu indulo protein transduction domine mariyu mitochondrial localization sequencelu untaayi.
saadhyamaina chikitsa upayogaalu.
mitochondrial vyaadhulaku oka parikalpana emitante, mitochondrial nashtam mariyu panicheyakapovadam vruddhaapyamlo mukhyamaina paatra poeshistaayi. lebers heridatory optic neuropathy vanti vaarasatvamgaa vacchina mitochondrial vyaadhulaku janyu chikitsalanu nirminchadaaniki protofection bahusha aacharaneeyamaina prayogasaala saanketikatagaa parisoedhimchabadutoemdi. protofection anedi lakshya kanaalalo merugaina mitochondrial paniteeruku daariteestundani adhyayanalu choopinchaayi.
protofection savarinchina ledhaa krutrima mitochondriaku vartimpajeyavachu. shakti utpattilo rajipadakunda mitochondrianu takkuva ledhaa free radicals utpatti cheyadaaniki savarinchavachhu. iteevali adhyayanalu mitochondrial marpidi anedi gundepotula vanti chanipoyina ledhaa maranistunna kanajaalaanni punarujjeevimpajeyadaaniki upayogapadutundani niroopinchaayi, dheeni kosam mitochondria anedi chanipoye kanamlo modati bhaagam.

