
4-hydroxyphenylpyruvate dioxygenase

4-hydroxyphenylpyruvate dioxygenase (hetch. pii. pii. dii), dheenini α-ketoisocaproate dioxygenase (kick dioxygenase) anie kooda pilustaaru, idhi phii (ii) kaligi unna naan-heam oxygenase, idhi tyrosine yokka catabolismlo rendava praticharyanu utprerakam chestundi-4-hydroxyphenylpyruvate homogentisetga marchadam. hetch. pii. pii. dii. phinylpyruvetnu 2-hydroxyphenilasetagte maarchadaaniki mariyu α-ketoisokaproyetnu β-hydroxy β-methylabutratega maarchadaaniki kooda utprerakam chestundi. hetch. pii. pii. dii anedi daadaapu anni aerobic roopaallo kanipinche enjaim.
enjaim mechanism.
hetch. pii. pii. dii anedi saadhaaranamgaa α-ketogluterate mariyu diatomic oxygennu upayoginchi lakshya anuvunu oxygenate cheyadaaniki ledhaa aakseekaranam cheyadaaniki upayoginche oxygenase enjaimla taragatilo vargeekarinchabadindi. ayithe, hetch. pii. pii. dii. eee taragatiloni chaalaa anuvula nundi bhinnamgaa untundi, endukante idhi α-ketogluterate upayoginchadu, mariyu idhi diatomic oxygen yokka rendu anuvulanu utpattilo, homogentisate loki jodinchetappudu rendu uparitalaalanu matrame upayogistundi. hetch. pii. pii. dii praticharya nih shift dwara sambhavistundi mariyu α-oxo aamlam yokka aakseekarana decorboxylationtho paatu sugandha ring hydroxylation kaligi untundi. isotope-labeling adhyayanala dwara pradarsinchabadina nih-shift, marinta sthiramaina kaarbokaatayaannu roopondinchadaaniki alkyl samuuham yokka valasanu kaligi untundi. shift, c3 anedi 4-hydroxyphenylpyruvate loe c4 thoo bandhinchabadi untundi conny homogentisate loe c5 thoo bandhinchabadi untundi anae pariseelanaku kaaranamavutundi. hetch. pii. pii. dii. yokka anchanaa yantraamgaanni eee krindi chitramlo chudavachuhu
nirmaanam.
hetch. pii. pii. dii anedi saadhaaranamgaa eucariotslo bacterialo tetramerlu mariyu diamerlu yerparuchukune bandham kaligina enjaim mariyu idhi <ii. dii. 1> keey. dii. yea. yokka upa-unit dravyaraasini kaligi untundi. enjaimnu enn-terminus mariyu sii-terminusga vibhajinchadam dwara enn-terminus kuurpuloo maarutuu undagaa sii-terminus saapekshamgaa sthiramgaa untundani gamaninchavacchu (mokkalalo sii-terminus itara jeevulalo sii-terminus nundi koddigaa bhinnamgaa untundi). 1999loe hetch. pii. pii. dii. yokka modati ex-rae sphatika shaastra nirmaanam srushtinchabadindi mariyu appati nundi hetch. pii. pii. dii. yokka kriyaaseela pradaesam enjaim yokka sii-terminus sameepamlo puurtigaa avasheshaalatho koodi undani kanugonabadindi. hetch. pii. pii. dii yokka kriyaaseela pradaesam puurtigaa mapp cheyabadaledu, conny eee sait beata sheetla nundi lopaliki vistarinche amaino aamlaalatoe chuttumuttabadina inupa ayaannu kaligi undani (sii-terminal helix minaha) telusu. enjaim yokka enn-terminus paniteeru gurinchi inca takkuva telisinappatikii, enn-terminal praantamloo oke amaino aamlam maarpu hakinsinuria anie piluvabade vyaadhiki kaaranamavutundani saastravettalu kanugonnaru.
function.
daadaapu anni aerobic jeevulalo, 4-hydroxyphenylpyruvate dioxygenase anedi 4-hydroxyphenylpyruvate homogentisetga maarchadaaniki baadhyata vahistundi. tyrosine acetoacetate mariyu fumaratega vichchinnam cheyadamlo eee marpidi aneka dasallo okati. eee chakram yokka mottam utpattulu saktini srushtinchadaaniki upayoginchabadutundagaa, mokkalu mariyu unnata shreni eukariotlu marinta mukhyamaina kaaranaala valla hetch. pii. pii. dii. nii upayogistaayi. eucariotslo, raktamlo tyrosine sthaayilanu niyantrinchadaaniki hetch. pii. pii. dii. nii upayogistaaru, mariyu mokkalu eee enjaimnu upayoginchi mokka manugadaku avasaramaina cofactors ayina plastoquinone mariyu tokopherolnu utpatti cheyadamlo sahaayapadataayi.
vyaadhi yokka praamukhyata.
raktapravaahamlo adhika sthaayi homogentisate valla kalige alcaptonuria anie piluvabade atyanta puraatanamaina vaarasatvamgaa vacchina jeevakriya rugmatalalo okadaanitoe hetch. pii. pii. dii. nii mudipettavacchu. maanava sareeramlo kriyaaseela hetch. pii. pii. dii enjaim gaadata takkuvagaa unnappudu hetch. pii. pii. dii. type III tyrosynemiatho kooda neerugaa mudipadi untundi, idhi raktamlo adhika sthaayilo tyrosine gaadataku daariteestundi, idhi puttinapudu telikapati manasika mandagamanaaniki kaaranamavutundi mariyu roogi peddayyaaka drushti ksheenistundi.
type I tyrosynemia, vaerae enjaim, fumarylacetoacete hydroless utparivartana chendutundi mariyu panicheyadu, idhi sareeramlo chaalaa haanikaramaina utpattulaku daariteestundi. fumarilacetoasetate hydroless hetch. pii. pii. dii. tarvaata tyrosynpy panichestundi, kabatti hetch. pii. pii. dii inhibitors taragatilo kalupu samhaarakaalanu tayaaru cheyadamlo panichestunna saastravettalu hetch. pii. pii. dii. nii nirodhinchadam mariyu aahaaramlo tyrosine niyantrinchadam eee vyaadhiki chikitsa cheyagaladani oohinchaaru. vaati sammelanaalalo okadaanitoe chinna clinical trials varusa prayatninchabaddaayi, niticinone nirvahinchabadindi mariyu vijayavantamaindi, idhi niticinone nuu anatha aushadhamgaa marketloki teesukuraavadaaniki daariteesindi.
paarisraamika sambandham.
mokkalalo avasaramaina cofactorlanu utpatti cheyadamlo hetch. pii. pii. dii paatra kaaranamgaa, eee enjaim yokka karyakalapalanu nirodhinche aneka vikrayinchabadina hetch. pii. pii. dii inhibitor herbicidelu unnaayi mariyu kotta vaatini kanugonadaaniki parisoedhanalu jarugutunnaayi.

