
kaardu 9

cospace recruitment domine kaligina protein 9 anedi card-sisi protein kutumbaaniki chendina adaptor protein, idhi maanavulalo "card 9" janyuvu dwara encode cheyabadutundi. idhi proo-inflammatory mariyu anty-inflammatory cytokinlanu sakriyam cheyadaaniki, mantanu niyantrinchadaaniki namuunaa gurtimpu graahakaala nundi sankethaalanu madhyavartitvam chestundi. carda9లoouu homozygus utparivartanalu kandida mariyu dermatophytes vanti eestsku vyatiraekamgaa lopabhuishta sahaja roganirodhaka saktitoe mudipadi untaayi.
function.
card9 anedi card protein kutumbaaniki chendina sabhyudu, idhi oka lakshanamaina cospace-sambandhita niyamaka domine (card) uniki dwara nirvachinchabadutundi. eee protein bcl10 yokka card domine, saanukuula niyantrakam mariyu nf-κb kriyaaseelatatoo daani empika anubandham dwara gurtinchabadindi. idhi nf-κbnii sakriyam chese bcl10 signalling complexes yokka assembleaki molecular paranjaga panichestundani bhaavistunnaaru. aneka pratyamnaayamgaa spliesed transcript vaividhyaalu gamaninchabaddaayi, conny vaati puurti-nidivi swabhaavam spashtamgaa nirvachinchabadaledu.
clinical praamukhyata.
2006loe, eestsku vyatiraekamgaa sahaja roganirodhaka pratispandanalo card9 mukhyamaina paatra pooshistundani spashtamaindi. card9 namuunaa gurtimpu grahakaalu (dectin-1) anie pilavabade vaati nundi nf-kebi vanti diguva sanketha maargaalaku sankethaalanu madhyavartitvam chestundi mariyu dheeni dwara shotha nirodhaka saitokinlu (tnf, ill-23, ill-6, ill-2) mariyu shotha nirodhaka cytokine (ill-10) mariyu taruvaata sankramananu tolaginchadaaniki tagina sahajamaina mariyu anukuula roganirodhaka pratispandananu sakriyam chestundi.
deerghakaalika shleshmam candidiasis kuu gurayye avakaasam yokka autosomal tirogamana roopam 2009loe card 9loe homozygus utparivartanaalato mudipadi unnatlu kanugonabadindi.
iranian kutumbamlo deep dermatophytosis mariyu card 9 lopam nivedinchabadindi, idhi lothaina dermatophytosis unna tunisian, algerian mariyu morocon kutumbaalaku chendina 17 mandiloo kanugonadaaniki daariteesindi.
carda9 utparivartanalu anchylosing spondylitis mariyu inflammatory pregu vyaadhi (crone 's vyaadhi mariyu vranotpatti peddapregu shotha) vanti inflammatory vyaadhulatoe mudipadi unnaayi. oka janyu roopaantaram, sii.IVs 11+1 g> c anedi manuel rivas, maark dolly mariyu sahacharulache crone 's vyaadhi, vranotpatti peddapregu shotha mariyu anchylosing spondilities nundi rakshanagaa unnatlu kanugonabadindi. card9 s12nδ11, oka arudaina splies roopaantaram, dheenilo "card9" looni exon 11 tolaginchabadutundi. eee yugmavikalpam, gawas loki yokka lothaina kramam dwara gurtinchabadutundi, phalitamgaa sii-terminal truncationtho kuudina protein erpadutundi. kriyaatmaka tadupari adhyayanamlo, murain "card9"-/-emuka majja nundi utpannamaina dendritic kanaalu (bmdc) loe tirigi vyakteekarinchabadina maanava card9 isopharmlanu upayoginchi cytokine utpatti kosam anchanaa veyabadindi. wild-type card 9nii vyakteekarinchae bmdclatho poliste, predisposing variant card 9 ess12ennu vyakteekarinchae bmdc luu tnfa mariyu il-6 utpattini penchaayi. dheeniki viruddhamgaa, card 9 δ11 mariyu card 9 ess12endi11, alaage sii-terminal kattirinchina variant card 9 vii6, tnfa mariyu il-6 utpattilo gananeeyamaina balaheenatanu choopinchaayi. maanava mariyu eluka dendritic kanaalalo wild-type card 9 thoo saha-vyakteekarinchinappudu card 9 δ11 card 9 paniteerupai prabalamaina pratikuula prabhavanni chooputundani kanugonabadindi.
jeevula namuunaa.
card 9 function adhyayanamlo namuunaa jeevulu upayoginchabaddaayi. welcome trust sangar institutelo "card9tm1eah (yucom) hamgu" anae sharatulatho kuudina nakout mouse line roopondinchabadindi. tolagimpu yokka prabhavalanu nirnayinchadaaniki maga mariyu aada jantuvulu praamaanika samalakshana teraku gurayyayi. adanapu teralu pradarsinchabaddaayih-lothaina roganirodhaka drugvishayam-lothaina emuka mariyu mrudulaasthi drugvishayam 

