
interleukin 16

interleukin 16 anedi proo-inflammatory pleotropic cytokine. dheeniki puurvagaami, proo-interleukin-16 anedi maanavulalo "ill16" janyuvu dwara encode cheyabadina protein. eee janyuvunu 1982loe boston vishwavidhyaalayamlo daa. david center mariyu daa. vilium crookshank.
function.
eee janyuvu dwara encode cheyabadina cytokine anedi pleotropic cytokine, idhi chemoatractantga, tii sell activation yokka modulatorga mariyu hechaivi replication yokka inhibitorga panichestundi. eee cytokine yokka sankethaala prakriya cd4 dwara madhyavartitvam cheyabadutundi. eee janyuvu yokka utpatti proteolytic prosessingku lonavutundi, idhi rendu kriyaatmaka proteinlanu istundi. cytokine function sravinche sii-terminal peptideku pratyaekamgaa aapaadinchabadindi, ayithe enn-terminal utpatti kana chakra niyantranalo paatra pooshinchavachchu. eee protein yokka proteolytic prosessinglo cospace 3 paalgontunnatlu nivedinchabadindi. vibhina isopharmlanu encoding chese rendu pratyaamnaaya spliesed transcript vaeriyantlu nivedinchabaddaayi. interleukin 16 (ill-16) vividha kanaala dwara (lymphocytelu mariyu konni epithelial kanaalatoe sahaa) vidudala cheyabadutundi, idhi kana uparitala anuvu sidi4నii vyakteekarinchae konni roganirodhaka kanaalaku chemoatractantga vargeekarinchabadindi. ill-16 modata maanavulalo sakriyaatmaka tii kanaalanu aakarshinchagala karakamga varninchabadindi, dheenini gatamlo lymphocyte chemoatractant phyaaktar (lcf) anie pilicheevaaru. appati nundi, eee interleukin monocytelu, isinophils mariyu dendritic kanaalatoe sahaa sidi4 anuvunu vyakteekarinchae aneka itara kanaalanu niyaminchi, sakriyam chestundani choopabadindi.
1994loe daani cloning taruvaata ill-16 yokka nirmaanam nirnayinchabadindi. eee cytokine puurvagaami peptide (proo-ill-16) gaa utpatti cheyabadutundi, dheeniki cospace-3 anae enjaim dwara prosessing avasaram. cd4 anedi parinati chendina il-16 kosam sell signalling receptor.
paraspara charyalu.
interleukin 16 dheenitho sankarshana chendutundani choopabadindihi