
taas1aarraa్1

ruchi grahaka rakam 1 member 1 anedi maanavulalo "taas1aarr1" janyuvu dwara encode cheyabadina protein.
nirmaanam.
taas1aarr1" janyuvu dwara encode cheyabadina protein anedi edu trans-membrane domainlatho kuudina zii protein-coupled receptor mariyu idhi heterodymeric amaino assid ruchi receptor tii1aarr1 + 3loe oka bhaagam. eee receptor taas1aarraa్1 mariyu taas1aarraa్3 proteinla diamerga erpadutundi. antekakunda, 1 + 3 heterodymer erpadataaniki velupala taas1aarraa్1 protein panicheyadu. taas1aarraa్1 + 3 grahakam ell-amaino aamlaalaku pratispandistundani choopabadindi, conny vaati dii-ananciomerlu ledhaa itara sammelanaalaku pratispandinchadu. ell-amaino aamlaalanu, mukhyamgaa ell-glutamine nuu bandhinche eee saamarthyam, sariiraaniki umami ledhaa ruchikaramaina ruchini grahinchadaaniki veelu kalpistundi. eee janyuvu kosam aneka vibhina isopharmlanu encoding chese bahula transcript vaividhyaalu kanugonabaddayi, ivi umami ruchiki vyaktula madhya vibhina ruchi parimitulaku kaaranam kaavacchu. taas1aarraa్1 mariyu taas1aarraa్2 proteinla yokka maroka aasaktikaramaina lakshanam extracellular domainlu mariyu binding ligandlu lenappudu vaati aakasmika kaaryaacharana. dheeni ardham, bahya kana domine yaadruchchika charyanu nivaarinchadam dwara alaage ell-glutamine vanti ligaandlanu sakriyam cheyadaaniki bandhinchadam dwara grahakam yokka paniteerunu niyantristundi.
ligands.
umami ruchi monosodium glutamate (msg) sammelanamtho spashtamgaa sambandham kaligi untundi. 1908loe japanese rasayana shaastravetta kikune ikeda samslaeshanha chesina eee ruchini penche sammelanam kotta ruchi naanhyataku "umami" anie paeru pettadaniki daariteesindi, idhi "ruchikaramaina" kosam japanese padam. taas1aarraa్1 + 3 ruchi grahakam msgloni glutamate paatu synergistic ruchi-penche anuvulu inosine monophosphate (imp) mariyu gwanosin monophosphate (gmp) kuu sunnitamgaa untundi. eee ruchi-penche anuvulu grahakanni matrame sakriyam cheyalevu, conny aneka ell-amaino aamlaalaku grahaka pratispandanalanu meruguparachadaaniki upayoginchabadataayi.
signal transduction.
taas1aarraa్1 mariyu taas1aarraa్2 grahakaalu zii proteinlatho bandhinchabadataayani choopabadindi, chaalaa tarachugaa gustducin jimm upaghatakam, ayithe gustducin nock-avt chinna avashesha karyakalapalanu choopinchindi. tas1r1 mariyu tas1r2 kooda gαo mariyu gαi nii sakriyam chestayani chuupabaddaayi. idhi taas1aarraa్1 mariyu taas1aarraa్2 anevi zii protein-coupled grahakaalu anie suuchistumdi, ivi ruchi grahakaalalo chakriya gwanosin monophosphate (cgmp) sthaayilanu tagginchadaaniki adenilyl cyclaselanu nirodhistaayi.
indriya zii-protein rendava sandesha vyavasthala dwara sakriyam cheyabadina saadhaarana chaanella nock-avutlanu srushtinchadam dwara chesina parisoedhana kooda umami ruchi avagahana mariyu phosphatidilinosital (pip2) maargam madhya sambandhaanni choopinchindi. naan selective katayan transient receptor potential chaanal (trpm5) umami mariyu teepi ruchi rendintitho sahasambandham kaligi unnatlu choopabadindi. alaage, phospholipase plcbt2 kooda umami mariyu teepi ruchitho samanamga sambandham kaligi unnatlu choopabadindi. zii-protein marganni sakriyam cheyadam mariyu eee ruchi kanaalalo plc β2 mariyu trpm5 chhaanel yokka tadupari kriyaaseelata kanaanni sakriyam cheyadaaniki panichestundani idhi suuchistumdi.
sthaanam mariyu invitation.
taas1aarraa్1 + 3 vyaktaparichae kanaalu ekkuvagaa naaluka kona mariyu anchula vadda unna shilindhra paapillelo mariyu noti paikappuloni angili ruchi grahaka kanaalalo kanipistaayi. eee kanaalu medaduku tama sankethaalanu pampadaaniki corda timpany naralapai samakaaleekarinchabadindani choopabadindi, ayinappatikee glosopharyngeal naram yokka kontha kriyaaseelata kanugonabadindi. taas1aarr mariyu taas2aarr (chedhu) chaanallu ruchi moggalalo kalisi vyakteekarinchabadavu.

