
aac/aad nayakudu

eaesi/eaedi 5 'leader anedi oka vivaadaaspada janyu moolakam, idhi bacterial aminoglycosides antibiatic-resistant janyuvula eguvana kanipinche mariyu aminoglycoside-nirdishta riboswichga panichese rakshita rna nirmaanamgaa pratipaadinchabadindi. aminoglycoside acetyl transferes (eaesi) mariyu aminoglycoside adenile transferes (eaedi) janyuvula paiki putative rna untundi.
prarambha nivedika prakaram, idhi resistance janyuvu yokka leader peptidenu eguva bhaagamlo encode chese chinna open reeding frame (orf) nuu kaligi undhi. modati ribozome binding sait nundi coding sequence varaku 75-nucleotide-podavaina sequence regulatory paatranu kaligi unnatlu kanipinchindi, mariyu idhi kaneesa functional rnaga pariganinchabadindi. pratipaadita namuunaa emitante, aminoglycosidelu aac/aad 5 'leader yokka nirdishta praantaalatoo bandhinchi, rna nirmaanamloo maarpunu prerepistaayi, tadwara diguva janyuvu dwara encode cheyabadina nirodhakata protein yokka vyakteekarananu prerepistundi. prarambha nivedikalo phalitaalu emitante leader rna antibiatic-resistant bacteria vyadhikaaraka karakalalo vistrutamgaa pampinhee cheyabadindi.
taruvaati lekha eee vaadanalanu vyatirekinchindi. eee lekha pratipaadita riboswich "atti" saitto saripolutundani perkondi, idhi gatamlo integranlalo telisina bhaagam mariyu integranlalo tarachugaa jarige prakriya ayina punassamyojanaaniki sanketam. itara amsaalatoe paatu, putative riboswich "atti" kosam gatamlo sthaapinchina vatiki minchi adanapu samrakshinchabadina lakshanaalanu kaligi ledani, riboswich/"atti" kooda aminoglycosidelaku sambandham laeni antibioticsku nirodhakatanu andinche janyuvulatho mudipadi unnayani (ledhaa itara sambandham laeni proteinlanu encode chestayani), mariyu asalu kaagitam yokka phalitaalanu rf thoo kuudina gatamlo spashtam chesina yantraangam dwara vivarinchavacchani lekha pratipaadinchindi. asalu patrika rachayitalu eee lekhaku pratispandananu prachurinchaaru.

