
alox 15

alox 15 (arachidonate 15-lipoxigenase, 15-lipoxigenase-1,15-loe-1,15-locks-1 anie kooda pilustaaru), itara lipoxigenessla maadirigaane, polyunsaturated kovvu aamlaala gvakriyalo oka seminal enjaim, idhi saareerakamgaa mariyu rogalakshanamgaa mukhyamaina utpattula vistruta shreniki.
Â janyu paniteeru
kelavkar mariyu badhar (1999) alox 15 janyu utpatti shotha nirodhaka, pora punarnirmaanam mariyu cancer abhivruddhi/metastasislo chikkukunnatlu paerkonnaaru. kelavkar mariyu badhar (1999) Tp53 janyuvu yokka nashtam, ledhaa daani utparivartana roopaala vyakteekarana phalitamgaa function karyakalapalu, maanavulalo mariyu elukalo alox15 prothsaahaka karyakalapalanu niyantristundi, ayithe disaatmakamgaa vyatiraeka paddhatiloo anae parikalpanaku maddatu ichhe daetaanu ichhe prayogaalanu vivarinchindi. eee adhyayanalu alox15 janyu karyakalapam mariyu chromosome sameepamlo unna sthirapadina kaniti-anachivese janyuvu madhya pratyaksha sambandhaanni nirvachinchaayi. kelavkar und badhar (1999) dheenini 15-lipoxygenes anedi utparivartana janyuvu anie rujuvugaa paerkonnaaru. 
mapping
maanava-hamster somatic hybrid dna panel, funk mariyu itarula pcr vislaeshanha dwara. (1992) 12-lipoxigenase mariyu 15-lipoxigenase janyuvulu maanava chromosome 17loe unnayani niroopinchagaa, atyanta sambandham laeni lipoxigenase (5-lipoxigenase) chromosome 10kii mapp cheyabadindi.
kelavkar mariyu badhar (1999) alox 15 janyu pataalu kaniti-anachivese janyuvu tipi53 (191170) kii daggaragaa 17p13.3 kuu unnayani paerkonnaaru. maanavulalo, idhi chromosome 17p13.3 paie unna alox15 janyuvu dwara encode cheyabadutundi. eee 11 kilobase jatha janyuvulo 662 amaino aamlaalatoe kuudina 75 kilodalton protein kosam 14 exanlu mariyu 13 intraanlu coding untaayi. 15-loe anedi maroka maanava 15-lipoxygenes enjaim, alox 15 bii (15-lipoxygenes-2 anie kooda pilustaaru) nundi vaeru cheyabadutundi. alox15 anie piluvabade alox15 yokka orthologlu, jantuvulu mariyu mokkala jaatulalo vistrutamgaa pampinhee cheyabadataayi, conny saadhaaranamgaa ververu enjaim karyakalapalanu kaligi untaayi mariyu alox15 kante kontha bhinnamaina utpattulanu tayaaru chestaayi.
naamakaranam.
human alox15కii modatlo arachidonate 15-lipoxigenase ledhaa 15-lipoxigenase anie paeru pettaru, ayithe tadupari adhyayanalu 15-lipoxigenase charyatho rendava maanava enjaimnu alaage vividha maanavetara ksheeradaala alox15 enjaimlanu kanugonnayi, ivi maanava alox15 yokka orthologlatho daggari sambandham kaligi untaayi. taruvaati alox15 enjaimlalo chaalaa varaku 15-lipoxigenase charyaku badulugaa pradhanamgaa ledhaa pratyaekamgaa 12-lipoxigenessnu kaligi untaayi. tatphalitamgaa, human alox15 ippudu arachidonate-15-lipoxigenase-1,15-lipoxigenase-1,15-locks-1,15-loe-1, human 12/15-lipoxigenase, leukocyte-rakam arachidonate 12-lipoxigenase ledhaa arachidonate omega-6 lipoxigenase anie pilustaaru. rendava maanava 15-lipoxigenase, alox15బii janyuvu yokka utpatti, dheenini alox15బii, arachidonate 15-lipoxigenase 2,15-lipoxigenase-2,15-locks-2,15-loe-2, arachidonate 15-lipoxigenase rakam II, arachidonate 15-lipoxigenase, rendava rakam, mariyu arachidonate 15-lipoxigenase; mariyu maanava alox15 yokka eluka, eluka mariyu kundelu elukala orthologlu, ivi maanava enjaimtho 74-81% amaino aamlam gurtimpunu panchukuntaayi, veetini saadhaaranamgaa alox15,12/15-lipoxigenase, 12/15-locks, ledhaa <ID2-loe) anie pilustaaru.
maanava alox 15 mariyu alox 15 bii janyuvulu rendoo chromosome 17loe unnaayi; vaati utpatti proteins amaino aamlam kramam gurtimpunu ~38% matrame kaligi untaayi; avi uparitalaalugaa ishtapade bahu asantrupta kovvu aamlalalo kooda bhinnamgaa untaayi mariyu oke uparitalaalapai panichesetappudu ververu utpatti profilenu pradarsistaayi.
kanajaala pampinhee.
maanava alox15 protein raktamlo prasaranalo unna isinophils mariyu reticulocytes, kanaalu, swaasanaala vayumarga epithelial kanaalu, ksheerada epithelial kanaalu, hodgekin yokka lymphoma yokka reed-sternberg kanaalu, corneal epithelial kanaalu mariyu dendritic kanaalalo ekkuvagaa vyakteekarinchabadutundi; idhi alviolar macrophaselu, tissue maast kanaalu, tissue fibroblastlu, prasarana rakta neutrophils, vascular endothelial kanaalu, joint sinovial membrane kanaalu, seminal fluid, prostate epithelium kanaalu mariyu ksheerada ductal epithelial kanaalalo takkuva balamgaa vyakteekarinchabadutundi.
upa-maanava primatelalo alox15 yokka pampinhee mariyu mukhyamgaa, elukalu maanava alox15 nundi gananeeyamgaa bhinnamgaa untaayi; idhi, vaati vibhina pradhana utpatti nirmaanamtho paatu (udhaa.zii. 15-heat kante 12-heat) eluka, eluka ledhaa kundelu namoonaalalo alox 15 vidhula yokka kanugonna vishayalanu maanavulalo alox 15 yokka paniteeruku bahirgatam cheyadam kashtataram chesindi.
enjaim karyakalapalu.
lipoxygenes kaaryaacharana.
alox 15 mariyu alox 15 enjaimlu heam kaanivi, iron kaligina dioxygenaselu. avi saadhaaranamgaa paramaanu praanavaayuvu yokka anubandhaanni polyunsaturated kovvu aamlalu (pufa) kuu peroxy avasheshamgaa utprerakam chestaayi, ivi rendu carbon-carbon double baandlanu kaligi untaayi, ivi maanava alox 15 kosam carbonlu 10 mariyu 9 mariyu 7 mariyu 6 madhya untaayi, ivi chivari ledhaa omega (i.ii. ω) pufa yokka methyl chivaralo carbon (eee carbonlanu ω-10 mariyu ω-9 mariyu ω-7 mariyu ω-6 anie kooda pilustaaru). ω-13 mariyu ω-12 carbonla madhya moodava carbon-carbon double bound laeni puphaslo, human alox 15 ω-6 peroxy intermediatlanu yerparustundi; eee moodava double bound unna puphaslo, human alox 15 ω-6 peroxy intermediatnu chestundi, conny ω-9 peroxy intermediate yokka chinna mottaalanu kooda chestundi. elukalu alox15 enjaimlu, dheeniki viruddhamgaa, daadaapu pratyaekamgaa ω-9 peroxy madhyavartulanu utpatti chestaayi. ekakaalamlo, alox15 mariyu elukalu alox15 enjaimlu carbon-carbon double baandlanu 1 "s"-hydroxy-2 "e", 4 "z"-daine aakruteekaranaloki teesukuraavadaaniki vaatini punarvyavastheekaristaayi. alox15 mariyu alox15 enjaimlu adhika sthaayi stereospeciphysito panichesi hydroperoxy avasheshaalanu stereoisomer aakruteekaranalo unche utpattulanu yerparustaayi.
lipohydroperoxidase charya.
human alox15 peroxy pufa intermediatnu moodu-anuvula valayamtho chakriya eethargaa kooda maarchagaladu, antey.ii. epoxy-hydropoxy pufa utpattulanu roopondinchadaaniki neeti anuvu daadi chese epoxide madhyantaram. eeyaaksinlu ex vivo human vascular endothelial modal systemlo vascular paaragamyatanu prerepistaayi.
leukotrene synthase kaaryaacharana.
alox15-eeoxin eah4 dwara tayaaraina arachidonic aamlam yokka pufa epoxidenu glutathiontho kalipi eeoxin bii4 nuu yerparustundi, eee utpattini eeoxin sii4 mariyu eeoxin dii4 gaa jeevakriya cheyavachu.
uparitalaalu, uparitala gvakriyalu mariyu jeevakriya karyakalapalu.
vaati saareeraka uparitalaalo, maanava mariyu elukala alox15 enjaimlu linoleic aamlam, alfa-linolenic aamlam, gaama-linolenic aamlam, arachidonic aamlam, icosapentenoic aamlam mariyu docosahexenoic aamlam meeda panicheestaayi, ivi uchita aamlalagaa matrame kakunda phospholipids, glycerides ledhaa collustroll esterlalo estarlugaa cherchabadinappudu kooda pradarsinchabadataayi. maanava enjaim mukhyamgaa linoleic aamlam meeda churukuga untundi, arachidonic aamlam kante ishtapadutundi. idhi udaharinchina lipidlalo estarlu ayina pufa meeda takkuva churukuga untundi.
arachidonic aamlam.
arachidonic aamlam (yeae) carbonlu 5-6,8-9,11-12, mariyu 14-15 madhya dwandwa bandhaalanu kaligi untundi; eee dwandwa bandhaalu sis loe untaayi (trans ledhaa "ii" aakruteekaranaku viruddhamgaa sis-trans isomerism ledhaa jedd chudandi). alox15 carbonlu 15 vadda eeki hydroperoxy avasheshaalanu jodistundi mariyu kontavaraku 12 nundi 15 ("luu")-hydroperoxy-5 "jedd", 8 "jedd", 11 "jedd", 13 "ii"-icosatetrenoic aamlam (15 ("luu")-hetch peat) mariyu 12 ("luu")-hydroperoxy-5 "jedd", 8 "jedd", 10 "ii", 14 jedd-icosatetrenoic aamlam (12 ("luu")-hetch peat); suddhi cheyabadina enjaim 15 ("luu")-hetch peat mariyu 12 ("luu")-hetch peat nuu utpatti nishpattilo yerparustundi. rendoo utpattulanu sarvavyaapta cellular glytohydroxy aamlam dwara vaegamgaa tagginchavachhu, vaati sambandhita hydrohydroxy aamlam (12-hydrohydroxy aamlam), 12-hydrohydroxy aamlam (12-hydrohydroxy aamlam), 12-hydrohydroxy aamlam 15 ("luu")-hetch peat mariyu 15 ("luu")-heat leukotrene bii4 receptor 2 thoo bandhinchi, sakriyam chestundi, peroxisome proliferator-activated receptor gamanu sakriyam chestundi mariyu adhika saandratala vadda kanaalu vishapuurita reactive oxygen jaatulanu utpatti chestaayi; eee prabhavalalo okati ledhaa anthakante ekkuva inflammatory pratispandanalanu prothsahinche, maanava cancer kana rekhala yokka vividha samayala perugudalanu marche, vividha rakaala rakta naalaalu kudinchagala, mariyu pulmonary aartareelu mariyu kaaleyamlo pathological fibrosisnu prerepinche vaati saamardhyaaniki paakshikamgaa baadhyata vahinchavachhu (15-hydroxycosatetreno acid#15 (luu)-hetch peat mariyu 15 (luu)-heat chudandi). 15 ("luu")-hpete mariyu 15 ("luu")-heatlu pora phospholipidluga esterify cheyabadataayi, akkada avi nilva cheyabadataayi mariyu taruvaata kana uddeepana samayamlo vidudala cheyabadataayi. eee prakriyaloo oka amsamgaa, erra rakta kanaala paripakvata samayamlo mitochondria pora phospholipidslo rendu utpattulu kramamga esterify cheyabadataayi (erythropoisis chudandi) mariyu tadwara mitochondria ksheenataku mariyu elukalalo erra rakta kanaalaku eee puurvagaamula paripakvataku sanketam ivvadaaniki upayogapadataayi. eee maargam rendu itara mitochondria-tolaginche maargaalato paatu panichestundi, anduvalla eluka erra rakta kanaala paripakvataku idhi avasaram anipinchadu.
15-("luu")-hett mariyu 15 ("luu")-heat vividha bioactive utpattulaku marinta jeevakriya cheyavachu, veetilo
alox15,12 (luu)-hetch peat mariyu 12 (luu)-heat yokka chinna utpattulu vistruta shreni karyakalapalanu kaligi untaayi. eee sammelanaalalo okati ledhaa rendu rendu rendu zii protein-coupled grahakaalu, gpr31 mariyu leukotrene bii4 grahakam 2; 12 "s"-heat kooda thromboxane grahakanni bandhinchadam dwara grahaka virodhigaa panichestundi, conny prerepinchadu, tadwara thromboxane eah2 mariyu prostaglandin hetch2 yokka charyalanu nirodhistundi (12-hydroxycosatetriano lakshyalu mariyu charya yokka yantraamgaalanu chudandi). eee grahaka-nirdesita charyala yokka pakshika paryavasanamga, okati ledhaa rendu alox15 utpattulu janthu namoonaalalo shotha-anukuula, madhumeham-prerepinche mariyu vasodilation karyakalapalanu pradarsistaayi; samskruti chendina maanava cancer kanaalapai cancer-prothsaahaka karyakalapalu; mariyu itara charyalu (12-hydroxycosatetriano acid#activities mariyu saadhyamayye clinical praamukhyata chudandi). eee rendu utpattulu vividha bioactive utpattulaku kooda jeevakriya cheyabadataayi, veetilo
docosahexenoic aamlam.
human alox15 docosahexenoic aamlam (dha) nuu 17 "s"-hydroperoxy-4 "jedd", 7 "jedd", 10 "jedd", 13 "jedd", 15 "ii", 19 "jedd"-docosahexenoic aamlam (17 "s"-hetchpiheche) mariyu 17 "s"-hydroxy-4 "jedd", 7 "jedd", 10 "jedd", 13 "jedd", 15 "ii", 19 "jedd"-docosahexenoic aamlam (17 "s"-hhhh) kuu jeevakriya chestundi. eee utpattulalo okati ledhaa rendoo maanava rommu mariyu prostate kana rekhalanu samskrutilo vistarinchadaaniki prerepistaayi mariyu 17 's-hda saktivantamaina pratyaekamaina parishkarinche madhyavarti karyakalapalanu kaligi untundi (pratyaekamaina parishkarinche mediators#dha-utpannamaina parishkaralanu chudandi). eee utpattulalo okati ledhaa rendintini enjaim dwara marinta jeevakriya cheyavachuhu
icosapentenoic aamlam.
human alox15 icosapentenoic aamlanni 15 "s"-hydroperoxy-5 "z", 8 "z", 11 "z", 13 "e", 17 "e"-icosapentenoic aamlam (15 "s"-hpePA) mariyu 15 "s"-hydroxy-5 "z", 8 "z", 11 "z", 13 "e", 17 "e"-icosapentenoic aamlam (15 "s"-hepa); 15 "s"-hepa proo-inflammatory madhyavarti, eltibi4, kanaalalo alox5-aadhaarita utpattini nirodhistundi, tadwara anty inflammatory functionku upayogapadutundi. eee utpattulanu marinta jeevakriya cheyavachuhu
enn-3 docosyexenoic aamlam.
maanava kanaalu mariyu eluka kanajaalaalu enn-3 docosapentenoic aamlam (i.ii., 7 "z", 10 "z", 13 "z", 16 "z", 19 "-docosapentenoic aamlam, clupanodonic aamlam chudandi) pratyaekamaina proresolvin madhyavartulugaa vargeekarinchabadina utpattula shreniki. dii 'snu parishkarinchadaaniki docosahexenoic assid metabolismtho saaruupyata aadhaaramgaa, 15-lipoxygenes, maanavulalo chaalaa matuku alox 15, eee metabolijaniki dohadam chestundani bhaavistunnaaru. enn-3 resulven dii (arvdn-3) luu anie piluvabade eee utpattuluh
linoleic aamlam.
maanava 15-locks-1 daani praadhamika uparitalamgaa arachidonic aamlam kante linoleic aamlanni ishtapadutundi, carbon 13 vadda oxygenate chesi 13 ("luu")-hydroperoxy-9 "z", 11 "e"-octadesenoic aamlam (13-hpode ledhaa 13 ("s")-hpode) nuu yerparustundi, idhi sambandhita hydroxy utpannam, 13 ("s")-hooad ledhaa 13-hooad (13-hydroxy octadecadianoic aamlam chudandi) kuu tagginchavachhu. 13 ("luu")-hodto paatu, mouse 12/15-locks mariyu soyabean 15-locks vanti maanavetara 15-locks1 orthologlu linoleic aamlanni 9-hydroperoxy-10 "e", 12 "z"-octadesenoic aamlam (9-hpode ledhaa 9 ("s")-hpode) gaa jeevakriya chestaayi, idhi vaegamgaa 9 ("s")-hooad (9-hooad) gaa maarchabadutundi (9-hydroxy octadecadianoic aamlam chudandi). 13 ("luu")-hooad peroxisome proliferator-activated receptorlu mariyu tripivi1 mariyu human gpr132 receptorla dwara monocyte maturation, lipid metabolism mariyu neuron activationku sambandhinchina vividha pratispandanalanu prerepinchadaaniki panichestundi (13-hoads yokka 13-hydroxy octadecadianoic aamlam ##activities chudandi); 9 ("luu")-hooad anedi oxidative stress thoo kuudina vyaadhulaku marker mariyu eee vyaadhiki alaage noppi avagahana mariyu atherosclerosisku dohadam cheyavachu (9-hydroxy octadecadianoic aamlam ##biological mariyu 9-hoads yokka clinical auchityam chudandi). rendu hoads vaati keatonlaku, 13-oxo-9 "z", 11 "e"-octadesenoic aamlam mariyu 9-oxo-10 "e", 12 "z"-octadesenoic aamlam varaku jeevakriya cheyavachu; eee keatonelu atherosclerosis, algimers vyaadhi, steatohepatitis mariyu itara rogalakshana paristhitula yokka shotha bhaagaaniki biomarkerluga mariyu sambhaavya sahakaruluga chikkukunnayi.
dihomo-zii-linolenic aamlam.
maanava neutrophils, bahusha vaati alox 15nii upayoginchi, dihomo-γ-linolenic aamlam (8 "z", 11 "z", 14 "z"-icosatrionic aamlam) nuu 15 "s"-hydroperoxy-8 "z", 11 "z", 13 "e"-icosatrionic aamlam mariyu 15 "s"-hydroxy-8 "z", 11 "z", 13 "e"-icosatrionic aamlam (15 "s"-hetter) gaa jeevakriya chestaayi. 15 "s"-hetter anty inflammatory activityni kaligi untundi.
janyu taarumaaru adhyayanalu.
carnia gaayam, vayumarga vaapu mariyu peritonitis yokka prayogaatmaka namoonaalalo vyaadhisaastraparamgaa merugaina shotha pratispandana yokka vividha itara amsaalatoe paatu vaari 12/15-lipoxygenes janyuvu (alox15) lopam unna elukalu sudeerghamaina shotha pratispandananu pradarsistaayi. eee elukalu atherosclerosis yokka vegavantamaina purogati retunu kooda chuuputaayi, ayithe 12/15-lipoxygenesnu atigaa vyakteekarinchadaaniki tayaaru cheyabadina elukalu atherosclerosis abhivruddhi yokka aalasyamaina retunu pradarsistaayi. alox 15 atigaa vyakteekarinchae kundellu periodontitis namoonaalo kanajaala naasanam mariyu emuka nashtam taggadaanni pradarsinchaayi. chivaraku, elukalanu niyantrinchandi, conny 12/15-lipoxigens lopam laeni elukalu endometriosis namoonaalo gaayaala sankhyanu tagginchadam dwara icospentenoic assid paripalanaku pratispandinchaayi. eee adhyayanalu vaapunu anachiveyadam anedi elukalalo utpatti chese 12/15-lipoxigenase mariyu pratyaekamaina parishkarinche madhyavartula yokka pradhana pani anie suuchistunnaayi; elukalu 12/15-lipoxigenase anedi maanava alox15 nundi bhinnamgaa unnappatikee, adhi utpatti chese pufa metabolites profile alaage vividha itara paaraamitulalo (udhaa.zii. kanajaala pampinhee), eee janyu adhyayanalu maanava alox 15 mariyu adhi utpatti chese pratyaekamaina parishkara madhyavartulu maanavulalo idhe vidhamaina pradhana shotha nirodhaka paniteerunu pooshinchavacchani anumatistaayi.
clinical praamukhyata.
shotha vyaadhulu.
janthu namoonaalalo bhaarii mariyu perugutunna adhyayanalu 15-locks-1 mariyu daani lipoxin, resolvin mariyu protection metabolites (pratyaekamaina proresolving madhyavartulanu chudandi) periodontitis, peritonitis, sepsis mariyu itara vyadhikaaraka-prerita taapajanaka pratispandanalato sahaa vividha taapajanaka vyaadhulanu nirodhinchadaaniki, parimitam cheyadaaniki mariyu parishkarinchadaaniki suuchistunnaayi; taamara, arthuritis, ubbasam, systic fibrosis, atherosclerosis mariyu kovvu kanajaala vaapu; madhumeham mariyu jeevakriya syndromtho sambandham unna oobakaayam loe sambhavinche insulin nirodhakatalo; mariyu algimers vyaadhiloo. eee adhyayanalu inca maanava vyaadhulaku anuvadinchaledani chuupimchinappatikii, modati mariyu rendava taram synthetic resulvinlu mariyu lipaxinlu, vaati sahaja saaruupyaala maadirigaa kakunda, jeevakriya nishkriyaatmakataku saapekshamgaa nirodhakatanu kaligi untaayi, ivi jantuvula namoonaalalo vaapu nirodhakaalagaa tayaaru cheyabaddaayi mariyu pareekshinchabaddaayi. eee synthetic analogues udaharinchina maanava shotha vyaadhula chikitsaku vaidyaparamgaa upayogakaramgaa niroopinchabadavacchu.
ω-3 polyunsaturated kovvu aamlalu, icosapentenoic aamlam mariyu docosahexenoic aamlam, 17-hphdha, 17-hdha, mariyu resulvinlu mariyu protetinlugaa jeevakriya cheyadam dwara, 15-locks-1 yokka jeevakriya charya anedi aahara ω-3 polyunsaturated kovvu aamlalu, mukhyamgaa chepala noone, vaapu, vaapu-sambandhita vyaadhulu mariyu konni cancerlu tagginchadaaniki panichese oka yantraamgaa bhaavinchabadutundi.
ubbasam.
15-locks-1 mariyu daani 5-oxo-15-hydroxy-eet mariyu eaxine metabolitelu maanava allergy-prerita ubbasam, aspirin-prerita ubbasam mariyu bahusha itara allergy vyaadhula yokka bhavishyat adhyayanam mariyu chikitsaku sambhaavya sahakaruluga suuchimchabaddaayi.
cancer.
colorectal, rommu mariyu moothrapindaala cancerlalo, cancerla saadhaarana kanajaala sahacharulatho poliste 15-locks-1 sthaayilu takkuvagaa ledhaa takkuvagaa untaayi mariyu/ledhaa cancerlu perige koddi eee sthaayilu gananeeyamgaa taggutaayi. eee phalitaalu, alaage elukalalo peddapregu concerpy 15-locks-1 transgene adhyayanam suuchistumdi, conny 15-locks-1 anedi kanitini anichivesedi anie niroopinchadu.
ω-3 polyunsaturated kovvu aamlalu, icosapentenoic aamlam mariyu docosahexenoic aamlam, lipaxinlu mariyu rijalvinlugaa jeevakriya cheyadam dwara, 15-locks-1 anedi aahara ω-3 polyunsaturated kovvu aamlalu, mukhyamgaa chepala noone, konni cancerla sambhavam mariyu/ledhaa purogatini tagginchadaaniki panichestundi. vaastavaaniki, samskarinchabadina maanava prostate cancer kanaala perugudalanu nirodhinche docosahexenoic aamlam yokka saamarthyam puurtigaa eee kanaala dwara 15-locks-1 vyakteekaranapai aadharapadi untundi mariyu eee enjaim 17 (luu)-hetch peat, 17 (luu)-heat vanti docosahexenoic aamlam jeevakriya yokka utpatti kaaranamgaa kanipistundi mariyu/ledhaa, bahusha, protection dx (10s, 17s-dihydroxy-4z, 7z, 11e, 13z, 15e, 19z-docosahexenoic aamlam) yokka isomer kaavacchu.
kelavkar mariyu.maanava pcalo, mukhyamgaa hye-grade pcalo, mariyu hye-grade prostatic intrapethylial neoplasia (hechjipin) loe 15-loe-1 yokka asaadhaaranamaina ativyaapti sambhavistundani, mariyu pca yokka esvi40-aadhaarita janyuparamgaa injaneering cheyabadina eluka (zem) namoonaalalo, laedii mariyu eluka prostate yokka transgenic adenocarcinoma vanti vaatilo murine ortholog perugutundani andaruu chuupimchaaru. eluka prostateku hetch15-loe-1 (maanava pca mariyu hechjipinlalo atigaa vyakteekarinchabadina janyuvu) yokka lakshyita athi vyakteekarana epithelial vistarana mariyu empin abhivruddhini prothsahinchadaaniki saripotundi. eee phalitaalu 15-loe-1 prostate kaniti praarambhamlo paatranu kaligi unnayani mariyu aahara ledhaa itara nivaarana vyuuhaalaku prarambha lakshyamgaa unnayani maddatu istayi. pca purogatiki avasaramaina paramaanu maarpula kalayikalanu marinta nirvachinchadaaniki itara ratna namuunaalatoe siluvalalo kooda flimp mouse modal upayogakaramgaa undaali.