
platelet membrane glycoprotein

platelet membrane glycoproteins anevi plateletla (thrombocytelu) paie kanipinche uparitala glycoproteins, ivi haemostasislo keelaka paatra poeshistaayi. raktanaala goda debbatinnappudu, platelet membrane glycoproteins extracellular matricks thoo sankarshana chendutaayi.
kollajenku platelet antukovadamlo palgone grahakaalu.
membrane glycoproteinline gpia/iia, gpvlu mariyu bahusha gpvlu kooda collagen grahakaalagaa panicheestaayi, ivi kollajenku platelet antukovadamlo nimagnamai untaayi. adhika ottidi gaayam tolagimpuloo pradhana paatra glycoprotein aibi-ikes-vii complexes dwara teesukobadutundi.
platelet uparitala glycoproteinla paraspara charyalu.
vaan willebrand karakam (vwf) yokka bandham gpb-vii-ikes complexes lopala conformational maarpulaku daariteestundi. paryavasanamga, eee sanklishtata gpba/iii pora glycoproteinlanu sakriyam chestundi, ivi fibrinogennu bandhinchadaaniki veelu kalpistaayi. fibrinogen anuvulu appudu plateletlanu parasparam anusandhaanistaayi, plateletla aggregationku aadhaaramgaa panicheestaayi. fibrinogen lenappudu, sakriyam cheyabadina gpba/iii complexenu bandhinche saamarthyam kaaranamgaa plateletlu vwf thoo kalustaayi.
membrane glycoproteins.
glycoprotein aibi-ikes-vii complexes (gpb-ikes-vii).
eee transmembrane glycoprotein complexes naalugu upabhaagaalato koodi untundih gpba, gpba, gpv mariyu gpics. vaatilo prati okkati lucine adhikamgaa unde punaraavruttula yokka chara sankhyanu kaligi untundi. gpba mariyu gpba disulfide vantenala dwara anusandhaaninchabadi undagaa, gpvlu mariyu gpics sanklishtatatoe samayojaneeyamgaa sambandham kaligi untaayi. gpba upaghatakam vaan willebrand karakam (vwf), α-thrombin, leukocyte integrin αmβ2 mariyu pii-selectin kosam binding saitnu kaligi untundi. gpbia mariyu vwf madhya bandham gayapadina vascular godaku plateletlanu pattukovadamlo madhyavartitvam chestundi. glycoprotein aibi-ikes-vii sanklishta samshlaeshanhaloo lopam bernard-solier syndromeku daariteestundi.
glycoprotein vi (gpv).
glycoprotein vi anedi immunoglobulin suupar family rakam ii transmembrane glycoproteinlalo okati. idhi collagen-prerita platelet kriyaaseelata mariyu samshlaeshanhaloo palgone mukhyamaina collagen grahakam. idhi vaati procagulant charyalo mariyu tadupari thrombin mariyu fibrin erpadatamlo keelaka paatra poeshistumdi. daani procagulant function dhamani ledhaa sirala raktam gaddakattadaaniki dohadam cheyavachu. gpvy kriyaaseelata yokka fcr maargamlo γ golusu (gpvy transmembrane domine associates vith γ chain fcr), src kines fine/linn mariyu lott adaptor protein untaayi, ivanni phospholipase sii kriyaaseelataloo palgontayi.
glycoprotein ii. yea/ii. ii. yea complexes (gpia/ii. ii. yea = integrin α2β1).
idhi collagen rakam I mariyu IV kosam oka grahakam. idhi rendu upabhaagaalanu (α2 mariyu β1) kaligi untundi. α2 upabhaagamlo kollajenku kattubadi vaan willebrand phyaaktar domainku samaanamaina domine untundi. β1 upaghatakam naalugu systeine-samruddhiga unde praantaalanu kaligi untundi mariyu itara β-integrinla maadirigaane oka nirmaanaanni kaligi untundi. collagen thoo paraspara charya plateletla sthireekaranaku daariteestundi. eee sanklishtata yokka uparitala vyakteekarana adhika vaividhyaanni chooputundi, mukhyamgaa gpia sub unit janyuvu yokka polymorphisionku sambandhinchi. 807 sthaanam vadda sii-tii point mutation yokka praamukhyatapai vividha abhiprayalu unnaayi, idhi myocardial inforction ledhaa ischemic stroke pramaadamtoe mudipadi undani nammutaaru.
glycoprotein iib/iia complexes (gpb/iia = integrin αiibβ3).
eee sanklishtata fibrinogentho sankarshana chendutundi, tadwara platelet aggregation mariyu endothelial uparitalaalaku antukovadamlo mukhyamaina paatra poeshistumdi. eee samudaayam yokka kriyaaseelata platelet aggregation mariyu praathamika platelet plug, fibrin gaddakattadam erpadataaniki praarambhistundi. iib/iia complexes anedi oka pradhana platelet pora bhaagam. daadaapu 50,000 kaapeelu unnaayi. αiib (gpiib) anedi disulfide vantenalatho anusandhaaninchabadina rendu upabhaagaalato koodi untundi. β3 (gpia) oke polypeptide golusunu yerparustundi. eee upabhaagaalu 1:1 nishpattilo platelet pora uparitalampai ca2 +-aadhaarita sanklishtatanu yerparustaayi.
glycoprotein iib/iia complexes dwara gurtinchabadina fibrinogen saitlu
eee sanklishtata vii. doubleu. eff, fibronectin mariyu vitronectinlanu kooda bandhistundi. vishraanti sthithilo rendu protein upa unitla madhya sambandham (sanklishta kriyaaseelataku avasaramainadi) agrigin dwara nirodhinchabadutundi, idhi sanklishta kriyaaseelataku avasaramaina vaati sambandhaanni nilipivestundi. sanklishtatanu ADP dwara sakriyam cheyavachu. ADP kii kattubadi unnappudu, agrigin anuvulo conformational maarpulu sambhavistaayi mariyu tatphalitamgaa, idhi rendu upa unitla nundi vidipotundi. antekakunda, complexenu thrombin dwara sakriyam cheyavachu. daani graahakaaniki thrombin bandham protein kines sii nii sakriyam chestundi mariyu innocital trifasphate sthaayini penchutundi. tatphalitamgaa, kalpeyinnu sakriyam chese calcium ayanlu vidudalavutaayi. calpine agriginnu cheelchivestundi, tadwara rendu upabhaagaalanu kalapadaniki anumatistundi. iib/iia complexelo lopaanni glanzmann yokka thrombastenia anie varnistaaru. rogulaku plateletlanu sameekarinche saamarthyam puurtigaa undadu.
gpv/iii (gpv/iia = integrin α5β1).
idhi heterodymer. dheeni α5 upaghatakam gpb upaghatakamtho 36 saatam samanamga untundi. eee samudaayam pradhanamgaa endothelial kanaalapai, conny mruduvaina kandara kanaalu, macrophaselu mariyu plateletlapy kooda undhi. dheeni pradhana pani kanaalanu extracellular matricks bhagalaku antukovadamlo untundi.

