
moxidectin

moxidectin anedi kukkalu, pillulu, gurralu, pasuvulu mariyu gorrelalo gunde purugu mariyu pegu purugulu vanti paraannajeevi purugulanu (helminths) nivaarinchadaaniki ledhaa niyantrinchadaaniki jantuvulalo upayoginche anthelmintic aushadham. paraannajeevi yokka glutamate-gated chloride ayan chaanellato empikagaa bandhinchadam dwara moxidectin konni atyanta saadhaarana antargata mariyu bahya paraannajeevulanu champutundi. akasheruka naraalu mariyu kandara kanaala paniteeruku eee margalu chaalaa mukhyamainavi; moxidectin maargaalato bandhinchinappudu, idhi naraala prasaaraaniki antaraayam kaligistundi, phalitamgaa pakshavaatam mariyu paraannajeevi maranam sambhavistundi.
vaidya upayogaalu.
rendu adhyayanala aadhaaramgaa united stateslo 11 ellu paibadina vyaktulaku 2018loe ancosersiasis (nadhi-andhatvam) kosam moxidectin aamodinchabadindi. pillalu mariyu prasava saamarthyam unna mahilallo nematode sankramana chikitsaku moxidectin surakshitamgaa mariyu prabhaavavantamgaa undho ledho anchanaa vaeyadaaniki deerghakaalika phaalo-aptho adanapu trials avasaram. eee vyaadhini nirmoolinche lakshyalanu saadhinchadaaniki moxidectin sahaayapadutundani anchanaa veyabadindi.
nematodlu moxidectin mariyu ivermectin, doramectin mariyu abamectin vanti itara saaruupya paraannajeevula madhya cross-resistancenu abhivruddhi cheyagalavu.
maanavulalo gajjini nirmuulinchadaaniki, mukhyamgaa itara chikitsalaku nirodhakata unnappudu, moxidectin chikitsanu anchanaa vestunnaru.
pratikuula prabhavalu.
moxidectin yokka adhyayanalu dushprabhaavaalu jantuvulanu batti maarutuu untaayani mariyu utpatti yokka suutreekarana, application paddhati mariyu motaadu dwara prabhaavitamavutaayani chuupistunnaayi.
moxidectin adhika motaadu kendra naadii vyavasthalo "gaama"-aminobutric aamlam (gaba) prabhavanni penchutundi. gurraalalo, adhika motaadu depression, diguva pedavi padipovadam, prakampanalu, kadulutunnappudu samanvayam lekapovadam (ataxia), swaasa raetu taggadam (swaasakosha raetu), muurcha mariyu komalaku daariteeyavachchu.
oka kukka "spot-aann" (samayochita) chikitsagaa upayoginchina charmam nundi moxidectin nuu nokkithe, idhi adhika motaadulo adhe prabhavanni kaligi untundi mariyu vaantulu, lalajalam mariyu ataxia, prakampanalu mariyu nistagmus vanti naraala sankethaalaku kaaranam kaavacchu. konni coley kukkalu moxidectinnu thattukogalavu, conny itara vyaktulu sunnitamgaa untaaru mariyu teesukunna tarvaata, vaantulu, lalajalam ledhaa taatkaalika naraala sankethaalanu anubhavistaaru.
aushadha shaastram.
moxidectin chaalaa lipophilic, idhi adhika parimaanamlo pampineeni kaligi undataaniki kaaranamavutundi. moxidectin jantuvu yokka kovvu kanajaalamlo kendrikrutamai untundi, akkada nundi adhi icchina tarvaata rendu nelala varaku vidudala avutundi.
mekallo, moxidectin noti dwara labhinche jeeva labhyata 2.7 retlu takkuvagaa untundi, mariyu sagam jeevitam gorrela kante 1.8 retlu takkuvagaa untundi.
rasayana shaastram.
milbemycin taragatiki chendina macrocyclic lactone ayina moxidectin, nemadectin yokka semisynthetic utpannam, idhi "streptomyces sinogrisus" subsp bacteria yokka puliyabettadam utpatti. "nansinogenous".
charitra.
1980la chivaralo, oka american sinamid company agronomist australia nundi matti namoonaalo moxidectin udbhavinchina "streptomyces" bacterianu kanugonnaru.
rendu companylu moxidectin kosam petentlanu daakhalu cheshai glaxo group mariyu american sinamid company; 1988loe, anni petentlu american sainamidku badilee cheyabaddaayi. 1990loe, modati moxidectin utpatti argentinalo vikrayinchabadindi.
maanava upayogam kosam, 12 mariyu anthakante ekkuva vayassu unna peddalu mariyu koumaaradasalo ancosersiasis chikitsa kosam united states phud und drugg administration 2018 juunloo moxidectinnu aamodinchindi. idhi prapanchavyaaptamgaa modati maanava aamodam. licenses holder anedi prapancha aarogyam kosam laabhaapekshaleni biopharmaceutical company medicines development.

