
kadile bays jatha

oka chalinche bays jatha anedi watson-crick bays jatha niyamaalanu anusarinchani rna anuvulalo rendu nucleotidela madhya jatha. naalugu pradhana asthiramaina muula jatalalo gwanin-eurasil (zii-yuu), hypoxanthine-eurasil (ii-yuu), hypoxanthine-adenine (ii-eah), mariyu hypoxanthine-cytosine (ii-sii) unnaayi. nucleic assid naamakarana sthirathvaanni konasaaginchadaaniki, hypoxanthine kosam "i" upayoginchabadutundi endukante hypoxanthine anedi inosine yokka nucleobase;
lekapothe nucleobasela paerlu mariyu vaati sambandhita nucleosidelanu (udhaa.zii.gwanin mariyu gwanosin rendintikee-alaage dioxiguanosine kosam). oka chalinche bays jatha yokka thermodynamic sthirathvam watson-crick bays jatatho polchavachhu. rna dviteeya nirmaanamloo chalinche bays jatala praadhamikamainavi mariyu janyu sanketam yokka saraina anuvaadaaniki keelakamainavi.
sankshipta charitra.
janyu sankethamlo, 43 = 64 saadhyamayye kodaanlu (3 nucleotide shrenulu) unnaayi. anuvaadam kosam, eee kodaanlalo pratidaaniki sthiramgaa puurti cheyagala anticodantho kuudina trana anuvu avasaram. prati trana anuvunu canonical watson-crick bays jatanu upayoginchi daani paripuurakaramaina mrna kodanto jatha chesthe, appudu 64 rakaala trana anuvulu avasaram avtayi. praamaanika janyu sankethamlo, eee 64 mrna kodaanlalo (uaa, yueji mariyu uga) moodu stop kodaanlu. ivi trana anuvula kante vidudala kaarakaalato bandhinchadam dwara anuvaadaanni mugistaayi, kabatti canonical jatha cheyadaaniki 61 jaatula trana avasaram. chaalaa jeevulalo 45 kante takkuva rakaala trana untaayi kabatti, konni trana rakalu bahula, paryaayapada kodanlatho jatha cheyavachu, ivanni oke amaino aamlanni encode chestaayi. 1966loe, frances crick dheeniki kaaranamaina asthira parikalpananu pratipaadinchaadu. mrnapy 3 'bays thoo bandhinche anticodon meeda 5' bays, itara rendu bays la vale praadesikamgaa parimitam kaaledani, anduvalla, praamaanikam kaani bays jatha cheyagaladani ayana pratipaadinchaaru. eee moodava codan sthaanam vadda sambhavinche chinna mottamlo "play" ledhaa chalanam kosam crick srujanaatmakamgaa dheeniki paeru pettadu. 5 'anticodon positionlo bays yokka kadalika ("chalanam") anedi trana yokka anticodanla mottam jatha jyaamitini prabhaavitam chese chinna conformational sardubaatlaku avasaram.
udaaharanaku, eest tranafelo anticodon 5 '-gmaa-3' untundi mariyu 5 '-yuusi-3' mariyu 5 '-yuyu-3' kodaanlanu gurtinchagaladu. anduvalla, watson kaani-crick bays jatha moodava codan sthaanam vadda jarige avakaasam undhi, antey.ii., mrna codan yokka 3 'nucleotide mariyu trna anticodon yokka 5' nucleotide.
kadile parikalpana.
eee bhavanala kaaranamgaa frances crick eee sahajamgaa sambhavinche lakshanaalanu vivarinche naalugu sambandhaala samiti ayina chalinche parikalpananu roopondinchaadu.
trna bays pairing skeemlu.
chalanam jatha niyamaalu. watson-crick bays jatalanu boldga chuupimchaaru. kundaleekaranaalu pani chese conny takkuva anukuulamgaa unde bandhaalanu suuchistaayi. oka pramukha x anedi anusarinche bays yokka utpannaalanu (saadhaaranamgaa) suuchistumdi.
jeevasambandhamaina praamukhyata.
chalanam yokka avasaranni pakkana pedithe, mana kanaalu parimita mottamlo tranalanu kaligi untaayi mariyu chalanam marinta vasyatanu anumatistundi, chalanam yokka bays jatala aneka jeevasambandhamaina vidhulanu sulabhataram chestayani choopabadindi, idhi "escherichia kooli" anae bacterialo, oka namuunaa jeevigaa spashtamgaa pradarsinchabadindi. nijaaniki, "ii" yokka adhyayanamlo. alanine kosam kooli yokka trana trana aminoacylated avtunda anie nirnayinche oka kadile bays jatha undhi. oka trana aminoasile trana synthetesku cherukunnappudu, synthetase yokka pani tii-aakaaramlo unna rnnu daani amaino aamlamtho kalapadam. eee aminoacylated tranalu mrna transcript yokka anuvaadaaniki velataayi mariyu ivi amaino aamlam yokka kodanku anusandhaaninche praathamika amsaalu. gwanine-eurasil jatha daani sahaja gwanine-cytosine jatagaa marchabade prayogam dwara chalinche bays jatha yokka avasaram vivarinchabadindi. oligoribonucleotide janyu kuurpu plus meeda samslaeshanha cheyabaddaayi, aapai alanine kosam oka trinanu code cheyadaaniki telisina dna kramamlo vyaapinchayi, 2dii-nmrs appudu eee kotta tranala utpattulapai amalu cheyabadataayi mariyu kadile tranalatho polchabadataayi. aaa chalinche bays jatha maaradamtho, nirmaanam kooda maarindani mariyu alfa helix ikapai erpadadani phalitaalu suuchistunnaayi. aminoasile trna synthetesku alfa helix gurtinchadagina nirmaanam, anduvalla synthetase amaino aamlam alanynnu alanine kosam tranatho anusandhaaninchadu. eee "e" loe amaino aamlam alanine vaadakaaniki eee chalinche bays jatha avasaram. kooli "mariyu ikkada daani praamukhyata aneka sambandhita jaatulalo praamukhyatanu suuchistumdi. aminoasile trna synthetase mariyu "ii" yokka janyuvulapai marinta samacharanni chudavachu. kolai "bahya linkula vadda trana", aminosyl trana syntheteslapy samacharam "mariyu" genomic trana database ".