
pluripotency (jeevasambandhamaina sammelanaalu)

jeeva sammelanaala yokka bahuvachana shakti aneka vibhina jeeva pratispandanalanu utpatti chese konni padaarthaala saamarthyaanni vivaristundi. pluripotent muula kanaala vishayamlo vividha kana rakalaga vaeru cheyagala saamarthyam unnatlugaa, pluripotentnu sthiramaina abhivruddhi saamarthyaanni kaligi laenidigaa kooda varninchaaru.
hematopoietic stem sell anie piluvabade oka rakamaina pluripotent sell, vividha vidhulu kaligina pedda rakaala kanaalugaa vaeru cheyagaladu. eee muula kanam erra rakta kanaalu, plateletlu, maast kanaalu, dendritic kanaalu, macrophaselu, lymphocytelu, neutrophils, basophils mariyu isinophilsnu utpatti cheyagaladu. eee kanaalalo prati okkati ververu vidhulanu kaligi untaayi, conny avanni roganirodhaka vyavasthalo bhaagamgaa kalisi panicheestaayi. 
monocytelu dendritic kanaalu ledhaa macrophaseluga vaeru cheyagalavu. macrophaselu rasayana grahakaalu mariyu phagocytos videshee kanaalatoe kappabadi untaayi, conny roganirodhaka pratispandanala gurinchi nirdishtamgaa untaayi. dendritic kanaalu phagocytos aakramanadaarulu; appudu vaaru pondina roganirodhaka vyavastha (lymphocytelu) nuu backupga prerepinchadaaniki vaari uparitalampai antigennu pradarsistaaru.
maroe udaaharana naiv tii-helper kanaalu anie piluvabade lymphocytelu. dendrites vanti antigen present kanaalu (eah. pii. sii. luu) dwara sakriyam cheyabadina tarvaata eee kanaalu aneka upa rakaluga vaeru cheyagalavu. avi konni paeru pettadaniki, memory sels, th1, th17, mariyu th2 sels gaa vibhajinchabadataayi. memory kanaalu reinfection vishayamlo upayoginchadaaniki oka templetnu kaligi undataaniki matrame tayaaru cheyabadataayi, tadwara sareeram eppuduu sokinatlugaa mallee praarambhinchadaaniki badulugaa jump start kaligi untundi. 17va kanaalu neutrophilsnu niyaminchadam, defencinlanu srushtinchadam mariyu pegu epithelium mariyu charmamlo vaapunu madhyavartitvam cheyadam vanti vividha panulanu chestaayi. th2 kanaalu konni bii kanaalanu prerepinche cytokinlanu utpatti chestaayi. bii kanaalu ghnaapakasakti kanaalu ledhaa plasma kanaalugaa vaeru cheyagalavu. bii plasma kanaalu daadi chese kanaalanu tagg cheyadaaniki upayoginche pratiroedhakaalanu utpatti chestaayi, tadwara vaatini itara vidhulatho paatu daadi cheyavachu. microphaselu mariyu cytotoxic tii lymphocytes (ctls) nuu sakriyam chese interferon gaama vanti cytokinlanu tayaaru cheyadaaniki th1 kanaalu srushtinchabadataayi.
interferon gaama anedi pluripotenseeki oka udaaharana. aneka saitokinlu pluripotent, dheenilo eee sammelanaalalo prati okkati konni kana rakaalalo nirdishta pravartananu sakriyam cheyagalavu mariyu itara kana rakaalalo itara pravartananu nirodhinchagalavu. tii lymphocytelu ledhaa sahaja killer kanaala dwara sakriyam cheyabadina tarvaata, interferon gaama macrophaselu mariyu rendu rakaala pradhana hystocompatability complexes (emhechsi) antigenla vyakteekarananu niyantristundi. bii lymphocytes (bii kanaalu) loe, interferon gaama antibody class switchingnu prerepistundi. eee kanaalannii vibhinnamaina, pratyaekamaina vidhulanu kaligi untaayi, conny avanni oke pluripotent sell nundi vachayi.

