
c1orf185

chromosome 1 open reeding frame 185, dheenini c1orf185 anie kooda pilustaaru, idhi maanavulalo "c1orf185" janyuvu dwara encode cheyabadina protein. maanavulalo, c1orf185 anedi takkuva vyaktaparichae protein, idhi appudappudu prasarana vyavasthalo vyakteekarinchabadutunda kanugonabadindi.
janyuvu.
c1orf185 anedi maanavulalo chromosome 1 meeda bays 51,102,221 mariyu 51,148,086 madhya saanukuula strandpy undhi. pradhana splies isopharmlo 5 exanlu unnaayi, ayithe isopharm aadhaaramgaa exanla sankhya mariyu empika maarutuu untundi.
mrna mariyu protein isopharms.
c1orf185 maanavulalo 5 ververu splies isopharmlanu kaligi undhi.
protein.
c1orf185 anedi pfam15842 protein kutumbaaniki chendinadi, idhi teliyani function, duf4718 yokka domaine kaligi undhi. eee proteinla kutumbam 130 mariyu 224 amaino aamlaala madhya podavu untundi mariyu eukariotlalo matrame kanipistundi..
c1orf185 yokka pradhana splies isopharm 22.4 kda paramaanu baruvu mariyu 7.67 isoelectric point kaligi untundi. idhi 15 nundi 37 sthaanaala varaku vistarinchi unna transmembrane domaine kaligi untundi. s123 nundi s142 varaku samrakshinchabadina serin-ritch praantam kooda undhi, idhi bahusha "spliesing activator" gaa pani cheyagaladu.
c1orf185loe 3 praadhamika upakana domainlu unnaih 1 nundi 14 sthaanaala varaku amaino aamlaalanu vistarinchi unna oka baahyakana domine, 15-37 sthaanaala nundi oka transmembrane domine mariyu 38-199 sthaanaala nundi pedda kanaantara domine.
krinda c1orf185 yokka dviteeya mariyu trutheeya nirmaanaalu anchanaa veyabaddaayi, ivi chow-fassman dviteeya nirmaana anchanaa sadhanam mariyu ii-tasser protein nirmaanam mariyu function anchanaa saadhananni upayoginchi roopondinchabaddaayi. chow-fassman α-helix, β-sheetlu mariyu itara nirmaanaatmaka malupulu mariyu coils misramaanni anchanaa vestaadu, veetini ii-tasser anchanaapai namoonaga chudavachu.
vyakteekarana yokka niyantrana.
janyu sthaayi niyantrana.
krinda c1orf185 promoterlo anchanaa vesina transcription phyaaktar binding saitla sthaanaalanu choopinche rekhaachitram undhi, prati vyaktigata binding sait yokka lakshanaalanu vivarinche pattikatho paatu. janyusambandhamaina eldorado saadhananni upayoginchi transcription karakalu kanugonabaddayi mariyu vislaeshimchabaddaayi.
matricks saaruupyata prati okka binding saitla anchanaapai vishwaasamtho sambandham kaligi untundi. +/- anedi saanukuula ledhaa pratikuula strandpy unikitho sambandham kaligi untundi. transcription karakalu pravartakudi prarambham nundi chivari varaku kanipinche kramamlo jabita cheyabaddaayi.
c1orf185 chaalaa takkuva vyakteekarana namuunaanu kaligi undhi, sareeramlo unna ekaika pradaesam vyakteekarana sankethaalu evaina circulatory system anie choopistundi. rendu enn. sii. bii. ii. geo profile rutukramam aagipoyina mahilala samuuhamloo mottam rakta namoonaalalo sii1rf185 sthiramgaa atigaa vyakteekarinchabadindani, alaage niyanthranalatho poliste parkinsons rogula paridheeya raktamlo kontha ekkuvagaa vyakteekarinchabadindani choopinchaayi.
transcript sthaayi niyantrana.
c1orf185 yokka 3 'utr yokka anchanaa vesina mrunaa nirmaanaanni choopinchadam dwara utpatti cheyabadina sankhya krinda undhi.
c1orf185 aneka orthologlalo 7merr-eah1 rakam yokka oka samrakshinchabadina mirna binding saitnu kaligi undhi. 7merr-eah1 binding sait undatam anedi sii1rf185 post-transcriptiontho anachiveyabade avakaasam undani suuchistumdi.
protein sthaayi niyantrana.
c1orf185 kosam anuvaadaanantara maarpu saitlanu anchanaa vesina oka chitram mariyu pattika krinda ivvabadindi.
rakta naalaalaloo protein paniteeru kolpovadamtho glycation mudipadi unnanduna, protein paniteerunu nirodhinchadaaniki margalu undavacchani bahula lucine glycation saitla uniki suuchistumdi.
clinical praamukhyata.
c1orf185 prasarana vyavasthalo oka paatra pooshistundani choopabadindi, idhi aneka jaatulalo takkuvagaa vyakteekarinchabadinanduna, marinta pratispandinche paatralo untundi. idhi karnika dada mariyu asaadhaarana qrs vyavadhi chuttoo unna adhyayanaalalo kanipistundi, idhi aaa prasarana vyaadhulalo paatra pooshinchavacchani suuchistumdi.
homology.
krinda vividha rakaala parirakshita jaatulalo c1orf185 aartolaaglanu choopinche pattika undhi. enn. sii. bii. ii. blast upayoginchi orthologlu kanugonabaddayi, timistryni upayoginchi divergence teedeelu kanugonabaddayi, clustal omega bahula kramam amarika saadhananni upayoginchi prapancha kramam gurtimpulu mariyu saaruupyatalu kanugonabaddayi.
itara janyuvulatho poliste, c1orf185 saapekshamgaa vaegamgaa abhivruddhi chendutunnatlu mariyu maarutunnatlu kanipistundi, endukante idhi ksheeradaalu mariyu konni taabellalo matrame samrakshinchabadutundi, mariyu marinta suduura ksheeradaalu chaalaa suduura saaruupyatalanu kaligi untaayi. maanava shreniki sambandhinchi eee janyuvunu bhaareega samrakshinche ekaika vargeekarana samuuham primatelu, ayithe itara ksheeradaalu mariyu taabellu transmembrane domaine matrame ekkuvagaa samrakshistaayi (sthaanaalu 15-37). primatelu mariyu ksheeradaalu vecchani raktamtho unnanduna, idhi prasarana vyavasthalo saadhyamayye paatranu choopinche aadhaaraalaku marinta maddatu ivvavacchu.