
tmem 275

tmem 275 (transmembrane protein 275) anedi maanavulalo tmem 275 janyuvu dwara encode cheyabadina protein. tmem275లoouu rendu, atyanta samrakshinchabadina, helical trans-membrane praantaalu unnaayi. idhi plasma pora ledhaa endoplasmic reticulum poralo nivasistundani anchanaa veyabadindi.
janyuvu.
locus.
maanavulalo, janyuvu chromosome byaand 1p33 paie mainus strandlo untundi. idhi pratyaekamgaa chromosome 1 paie chr 1:46,532,166-46,543,969 vadda untundi. tmem275 podavu 11,804bp.
janyu porugu praantam.
tmem275 yokka eguva bhaagamlo, mainus strandpy, maroka janyuvu; kncn.
transcripts.
tmem 275 janyuvu naalugu exanlanu encode chestundi, veetilo moodu matrame tudi mrna transcript loe cherchabaddaayi. aaa moodintilo rendu 5 'utr mariyu 177 amaino aamlaala coding sequence kodlalo unnaayi. tmem275 rendu daani reference transcript velupala rendu sambhaavya isopharmlanu kaligi unnatlu kanugonabadindi. reference isopharmlo exon 1 undadu, ayithe isopharm x1loe 5 'utr mariyu isopharm x2loe 3' utr untundi. ayithe, mrna transcripts yokka anni versionlu oke 177 amaino assid kramaanni istayi.
protein.
saadhaarana lakshanaalu.
tmem 275 proteinlo 177 amaino aamlalu untaayi, anchanaa vesina paramaanu dravyarashi 17.2 kda mariyu 8.13 paie. tmem 275 chaalaa proteinla kante alanine mariyu prolin amaino aamlam avasheshaalu ekkuvagaa unnatlu kanugonabadindi. itara jaatulalo orthologous proteinla shrenulanu chusinappudu, alanine uniki antataa samrakshinchabadindi, conny prolin uniki gurinchi adhe cheppalemu.
praathamika kramam.
tmem275 yokka proteinlo 177 amaino aamlalu untaayi. coding kramam dwara encode cheyabadina protein ledhaa polypeptide golusu, anuvaada prakriya dwara tayaaru cheyabadutundi mariyu aasakti unna itara praantaalalo krinda choopabadindi. 3 'utr chivarilo paalii-eah ledhaa polyadenylation signal kooda untundi.
domainlu.
tmem275లoouu rendu, atyanta samrakshinchabadina, helical trans-membrane praantaalu unnaayi. oodaa rangulo sambhaavita anuvaadamlo paina perkonna amaino aamlam kramamlo praantaalanu chudavachu. parinaamaatmaka vislaeshanha eee trans-membrane domainlu anni ortholog vargeekaranalalo baga samrakshinchabaddaayani choopinchindi.
dviteeya nirmaanam.
tmem275 kosam anchanaa vesina dviteeya nirmaanaanni vislaeshimchadaaniki aneka karyakramalu upayoginchabaddaayi. idhi atyanta vaividhyamaina nirmaanaanni kaligi unnatlu kanugonabadindi. ayithe, prediction dayta rendu transmembrane domainla yokka alfa helical nirmaanaaniki maddatu istundi.
niyantrana.
janyu sthaayi niyantrana.
prothsaahakulu.
anchanaa vesina prothsaahaka praantam 1116 bipi podavu mariyu chromosome 1 paie mainus strandpy undhi mariyu 46535401-46536515 nundi vistarinchi undhi.
transcription phyaaktar binding saitlu.
genomatics dwara eldoradoni promoterloni top 20 transcription phyaaktar binding saitlanu vislaeshimchadaaniki upayoginchaaru.
vyakteekarana namuunaa.
pregulalo garbham daalchina 11 vaaraala samayamlo tmem 275 yokka rna sthaayilu chaalaa ekkuvagaa untaayi. konni itara mukhyamaina sikharaalalo oopiritittulu, moothrapindaalu mariyu adrenal kanajaalaalu varusaga 10,16 mariyu 20 varalalo untaayi. pareekshinchina 20 maanava kanajaalaalo, pindam medadu kanajaalamlo rna mukhyamgaa undani kooda kanugonabadindi. kanajaala rakaalapai tadupari pareeksha anedi vrushanhaalu, medadu mariyu prostate tmem275 kanajaala-nirdishtatanu kaligi undavacchani kanugonadaaniki daariteestundi. thyroid mariyu andaasayaalatoo paatu.
protein sthaayi niyantrana.
upa kana sthaanikeekarana.
tmem 275 plasma pora ledhaa endoplasmic reticulum pora lopala untundani anchanaa veyabadindi.
anuvaadaanantara maarpulu.
tmem275 thoo anubandham kosam vividha ptmlu vislaeshimchabaddaayi. indulo sumo-motif, acetylation saitlu, signal peptides uniki mariyu edainaa oo-glcnac sait mariyu enn-myristillation anchanaalu unnaayi.
homology.
paralogs.
tmem275 kosam telisina peraalaaglu laevu.
homologs.
tmem275loe homolaglu ledhaa homolagus domainlu laevu.
orthologs.
mottam 105 jeevulu maanava tmem 275 janyuvulatho aartholaaglanu kaligi unnatlu kanugonabadindi, ivanni telostomy ledhaa davada sakasherukaalu, clade loe oka bhaagam. orthologus gala 105 jeevulalo tmem275:49 ksheeradaalu, 27 pakshulu, 3 taabellu, 3 ballulu, 3 ubhayacharaalu, 19 emuka chepalu mariyu 1 mosali.
saatam gurtimpu dwara atyanta saaruupya shrenulu kaligina samuuham aascharyakaramgaa ksheeradam. manavulaku sambandhinchi aaa orthologus proteinla saatam gurtimpulu 52.1% nundi 70.9% varaku unnaayi. orthologus timem 275 kaligi unna samuuham, conny kaneesam saaruupyata kaligi unna samuuham octinopterigi ledhaa emuka chepalu. vaati saatam saaruupyatalu 38.5% nundi 47.6% varaku unnaayi. maanava proteinku vyatiraekamgaa prati jaatilooni prati orthologous protein yokka jatha vaareegaa vislaeshanha nirvahinchadam dwara saatam saaruupyatalu kanugonabaddayi.
phylogeny.
janyu roopaanni.
timem 275 emuka chepalu ledhaa octinopterigi lopala 435 miah kanipinchinatlu telustondi. 
paraspara proteins.
tmem275 kosam telisina protein paraspara charyalu laevu.
clinical praamukhyata.
tmem275కii vaidya vyaadhitho etuvanti sambandham ledhu.