
fineron

serendia anae brand paerutoe vikrayinche fineron, moothrapindaala paniteeru ksheenata, moothrapindaala vaiphalyam, hridayanaala maranam, praanaantakamaina gundepotu mariyu type 2 diabetisto sambandham unna deerghakaalika moothrapindaala vyaadhi unna peddalalo gunde vaiphalyam kosam aasupatrilo cheradam vanti pramaadaanni tagginchadaaniki upayoginche aushadham. fineron anedi steroid kaani mineralocarticoid grahaka virodhi (mra).
saadhaarana dushprabhavalalo hypercalemia (adhika potassium sthaayilu), hypotension (takkuva raktapotu) mariyu hyponetramia (takkuva sodiyam sthaayilu) unnaayi.
united stateslo juulai 2021loe, mariyu european unionlo fibravari 2022loe vaidya upayogam kosam fineron aamodinchabadindi.ess. aahara mariyu aushadha paripalana dheenini modati-sthaayi aushadhamgaa pariganistundi.
vaidya upayogaalu.
united stateslo, moothrapindaala paniteeru ksheenata, moothrapindaala vaiphalyam, hridayanaala maranam, praanaantakamaina gundepotu mariyu type 2 diabetisto sambandham unna deerghakaalika moothrapindaala vyaadhi unna peddalalo gunde vaiphalyam kosam aasupatrilo chere pramaadaanni tagginchadaaniki fineron soochinchabadindi.
european unionlo, peddalalo type 2 diabetisto sambandham unna deerghakaalika moothrapindaala vyaadhi (albuminuriyato dasha 3 mariyu 4) chikitsa kosam fineron suuchimchabadutumdi.
aushadha shaastram.
prastutam andubaatulo unna applerenone mariyu spironolactone vanti aldosteron antagonistla kante itara steroid harmon graahakaalato fineron takkuva saapeksha anubandhaanni kaligi undhi, idhi gynecomastia, napumsakatvam mariyu takkuva kaamashakti vanti takkuva pratikuula prabhaavaalaku daari teestundi.
fineron mineralocarticoid grahakalanu nirodhistundi, idhi potassium-rakshinche moothravisarjananu chestundi.
eee pattika moodu antimineralocarticoide yokka inhibitory (blocking) saandratalanu (aisi 50, unit nm) polchi chustundi. mineralocarticoid grahaka nirodham mandula yokka kaavalasina charyaku baadhyata vahistundi, ayithe itara graahakaala nirodham dushprabhaavaalaku daariteestundi. takkuva viluvalu antey balamaina nirodham.
paina perkonna mandulu eastrogen graahakaaniki chaalaa takkuva anubandhaanni kaligi untaayi.
spironolactone mariyu appleronone vanti itara saampradaaya mr inhibitors maadirigaa kakunda, yaadrucchikamgaa agonistulugaa panichese, ess810ell mutationku aasrayam kalpinche mineralocarticoid graahakaalaku finerone oka virodhigaa panichestundi.
edu yaadruchchika niyantrita trials (13,783 mandhi paalgonevaaru) nundi dayta yokka meta-vislaeshanha diabetic moothrapindaala vyaadhi mariyu overt proteinuria unnavaarilo fineron upayoginchadam valla prayojanam undani kanugonnaru.
pratikuula prabhavalu.
fineron electrolyte asamatulyataku kaaranam kaavacchu, dheenini aarogya samrakshana nipunulu parishkarinchaali. potassium vishayamlo, fineron teesukune rogulu raktamlo potassium adhika sthaayini anubhavinchavacchu. eee clinical anveshanhatho sambandham unna lakshanaalu vikaram, balaheenata, chaatii noppi mariyu kadalika kolpovadam. fineron unna rogulaku sambhavinche maroe saadhaarana electrolyte asamatulyata emitante, rogulaku takkuva sodiyam undavacchu, idhi talanoppi, gandaragolam, balaheenata mariyu rogulaku samatulyata laeni anubhootigaa vyaktamavutundi.
charitra.
moothrapindaalu mariyu gunde phalitaalanu meruguparachadaaniki fineron yokka saamarthyaanni type 2 diabetisto sambandham unna deerghakaalika moothrapindaala vyaadhi unna peddalalo yaadruchchika, bahula kendra, double blind, placebo-niyantrita adhyayanamlo anchanaa veyabadindi. eee adhyayanamlo, 5,674 mandhi paalgonevaaru yaadrucchikamgaa fineron ledhaa placeboni sweekarinchadaaniki ketayinchabaddaru.
moothrapindaala paniteerulo kaneesam 40 saatam taggudala, moothrapindaala vaiphalyaaniki purogati ledhaa moothrapindaala maranamtho kuudina mishrama (ledhaa samyukta) mugimpu binduvuku vyaadhi purogaminchina palgonevari sankhya kosam adhyayanam rendu samuuhaalanu polchindi. phalitaala prakaram, finerenone pondina 2,833 mandhi paalgonevaarilo 504 mandhi mishrama mugimpu binduvulo kaneesam oka sanghatananu kaligi unnaarani, placebo pondina 2,841 mandhi paalgonevaarilo 600 mandhi unnaaru.
yuu.ess. phud und drugg administration (fda) finerone praadhaanyata sameeksha mariyu faast track hodaalu kosam darakhaastunu manjuru chesindi. bayer healthcareku kerendia aamodam ivvadaaniki fda aamodam telipindi.
samajam mariyu samskruti.
chattaparamaina sthithi.
16 december 2021naa, european medicines agency (ii. emm. yea) yokka maanava upayogam kosam aushadha utpattula kamitee (ch. emm. pii) saanukuula abhiprayanni sweekarinchindi, peddalalo type 2 diabetisto sambandham unna deerghakaalika moothrapindaala vyaadhi chikitsa kosam uddesinchina aushadha utpatti kerendiaku marketing adhikaram manjuru cheyaalani sifaarasu chesindi. eee aushadha utpattiki darakhaastudaaru bayer ag. fibravari 2022loe european unionlo vaidya upayogam kosam fineron aamodinchabadindi.
parisoedhana.
rendava dasalo arts-dn adhyayanamlo, diabetic moothrapindaala vyaadhi unna rogulalo fineron motaadu-moothramlo albuminnu creatinine nishpattiki tagginchindi. eee phalitaala aadhaaramgaa, deerghakaalika moothrapindaala vyaadhi mariyu type 2 diabetes unna rogulalo sii. keey. dii purogati mariyu pratikuula hridaya sambandha sanghatanala pramaadaanni fineron taggistundaa anie anchanaa vaeyadaaniki roopondinchina pedda dasha III fidelio mariyu figaro phalita adhyayanaalalo fineron adhyayanam cheyabadutondi. eee trials loe 13,000 mandiki paiga rogulanu namodu chesaaru, 2020 loe fidelio mariyu 2021 loe figaro praathamikamgaa puurtavutumdani anchanaa.