ruxolitinib

ruxolitinib, jakafi anae brand paerutoe vikrayinchabadutundi, idhi emuka majjanu prabhaavitam chese oka rakamaina myeloproliferative neoplasm, intermediate ledhaa adhika-pramaada myelophybrosis chikitsa kosam upayoginche aushadham; hydroxyuria yokka taginanta pratispandana ledhaa asahanam lenappudu polycythemia vera; mariyu steroid-vakreebhavana teevramaina graft-verses-host vyaadhi. ruxolitinib anedi jaanas kines inhibitor. dheenini united stateslo insite corp jakafi anae brand paerutoe mariyu prapanchamlooni itara praantaalalo novartis jakavi anae brand paerutoe abhivruddhi chesi vikrayinchindi.
idhi idhi united stateslo mariyu marchi european unionlo vaidya upayogam kosam aamodinchabadindi. kodipilla rogulalo punahroopakalpananu parishkarinchadaaniki ruxolitinib anedi modati fda-aamodinchabadina aushadha chikitsa.
vaidya upayogaalu.
united states mariyu european unionlalo, praathamika myelophybrosis (chronic idiopathic myelophybrosis anie kooda pilustaaru), post-polycethemia-vera myelophybrosis ledhaa post-essential thrombocythemia myelophybrosis unna peddalalo vyaadhi-sambandhita pleehamu ledhaa lakshanaala chikitsa kosam ruxolitinib suuchimchabadutumdi. hydroxyuriaku nirodhakata ledhaa asahanam unna polycythemia vera unna peddala chikitsa kosam kooda idhi suuchimchabadutumdi. pannendu samvatsaraalu mariyu anthakante ekkuva vayassu unnavaarilo steroid-refractory acute graft-verses host vyaadhi chikitsa kosam mariyu pannendu samvatsaraalu mariyu anthakante ekkuva vayassu unnavaarilo okati ledhaa rendu rakaala daihika chikitsa viphalamaina tarvaata chronic graft-verses host vyaadhi (sii. zii. vii. hetch. dii) chikitsa kosam kooda ruxolitinib suuchimchabadutumdi.
united stateslo, ruxolitinib cream telikapati nundi mitamaina autopic dermatitis mariyu kodipillala samayochita chikitsa kosam suuchimchabadutumdi.
european unionlo, 12 samvatsaraala vayassu nundi peddalu mariyu koumaaradasalo unnavaarilo mukha prameyam thoo naan-segmental vitiligo chikitsa kosam ruxolitinib cream suuchimchabadutumdi.
dushprabhaavaalu.
myelophybrosislo, atyanta saadhaarana dushprabhavalalo thrombocytopenia (takkuva rakta platelet gananalu), raktaheenata (takkuva erra rakta kanaala gananalu), neutropenia (neutrophils takkuva sthaayilu), moothra naalaala infections (moothrapindaalu, moothrapindaala pottikadupu, moothra naalaalu, muutraasayam ledhaa muutranaalaala sankramana), raktasraavam, gayalu, baruvu peragadam, hyper collusterolemia (adhika rakta collustroll sthaayilu), maikamu, talanoppi mariyu kaaleya enjaim sthaayilu peragadam unnaayi.
polycythemia veraalo, atyanta saadhaarana dushprabhavalalo raktaheenata (takkuva erra rakta kanaala gananalu) mariyu thrombocytopenia (takkuva rakta plateletla ganana), raktasraavam, gayalu, hyper collusterolemia (adhika rakta collustroll sthaayilu), hypertriglygeridemia (adhika raktamlo kovvu sthaayilu), maikamu, perigina kaaleya enjaim sthaayilu mariyu adhika raktapotu unnaayi.
teevramaina antu-verses host vyaadhiloo, atyanta saadhaarana hematologic pratikuula praticharyalalo raktaheenata, thrombocytopenia mariyu neutropenia unnaayi. atyanta saadhaarana nonhematologic pratikuula praticharyalalo infections mariyu vaapu untaayi.
roganirodhaka dushprabhavalalo herpes joster (shingles) mariyu avakaasavaada infectionla kesu nivedikalu unnaayi. jeevakriya dushprabhavalalo baruvu peragadam kooda undhi. prayogasaala asaadhaaranatalaloo alanine transominage (alt) asaadhaaranatalu, aspartate transominage (esty) asaadhaaranatalu mariyu collustroll sthaayilu swalpamgaa perigayi.
charya yokka yantraangam.
ruxolitinib anedi nirodhistundi mariyu mariyu uparakaala empikatho kuudina jaanas kines inhibitor ("jaak" inhibitor). ruxolitinib myelophybrosisto sambandham unna diseregulated jaak signalingnu nirodhistundi. nirodhistundi mariyu mariyu sanketha sangnaamaanam mariyu pratilekhana (ganaamkaalu) yokka kriyaaseelakaalanu cytokine graahakaalaku niyamistaayi, idhi janyu vyakteekarana yokka modulationku daariteestundi.
charitra.
marchi marchi, moodava dasha niyantrita myelophybrosis adhyayanam oral jaak inhibitor-ii (comfort-ii) mariyu comfort-III trials pleehamu parimaanaanni tagginchadam mariyu balaheenapariche lakshanaalanu upasamanam cheyadam dwara gananeeyamaina prayojanaalanu choopinchaayi.
samajam mariyu samskruti.
chattaparamaina sthithi.
2011 navambarulo, ruxolitinibnu yuu aamodinchindi.ess. comfort-I mariyu comfort-III trials phalitaala aadhaaramgaa intermediate ledhaa hye-risk myelophybrosis chikitsa kosam phud und drugg administration (fda).
(fda), pratispandana vichaarana aadhaaramgaa hydroxyuriaku taginanta pratispandana ledhaa asahanam lenappudu polycythemia veraalo idhi aamodinchabadindi.
2019 maeloe, steroid-vakreebhavana teevramaina graft-verses host vyaadhini chaerchadaaniki uslo ruxolitinib suuchana vistarinchabadindi. 12 samvatsaraalu mariyu anthakante ekkuva vayassu unnavaarilo okati ledhaa rendu rakaala daihika chikitsa viphalamaina taruvaata deerghakaalika graft-verses host vyaadhi (sii. zii. vii. hetch. dii) chikitsa kosam 2021 septemberlo uslo eee suuchana marinta vistarinchabadindi.
septembaru septembaru, telikapati nundi mitamaina autopic dermatitis (AD) chikitsa kosam united stateslo vaidya upayogam kosam ruxolitinib cream (opjelura brand paerutoe vikrayinchabadindi) aamodinchabadindi. idhi united stateslo aamodinchabadina modati samayochita jaanas kines inhibitor.
juulai juulai, ruxolitinib cream (opjelura brand paerutoe vikrayinchabadindi) united stateslo bolli chikitsa kosam vaidya upayogam kosam aamodinchabadindi.
2023 fibravari 23naa, european medicines agency (ii. emm. yea) yokka maanava upayogam kosam aushadha utpattula kamitee (ch. emm. pii) saanukuula abhiprayanni sweekarinchindi, segmental kaani vitiligo chikitsa kosam uddesinchina aushadha utpatti opjelura kosam marketing adhikaranni manjuru cheyaalani sifaarasu chesindi. eee aushadha utpattiki darakhaastudaaru insite biosciences distribution bii.vii.
parisoedhana.
idhi plake psoriasis, alopesia ariata, relopsed diffuse large bii-sell lymphoma mariyu paridheeya tii-sell lymphoma kosam parisoedhimchabadutoemdi.
fibravari fibravari, pancreatic cancer kosam moodava dasha vichaarana taginanta samarthatha lekapovadam valla nilipiveyabadindi.
ruxolitinib blunted senescent sell-madhyavartitva adipogenesis nirodham mariyu 22 nelala elukalalo insulin sunnitatvaanni penchadamtho enimidi vaaraala chikitsa.
september 2019 natiki, "ruxolitinib plus tyrosine kines inhibitorsto kalayika chikitsa tarvaata chikitsa rahita upasamanam" nuu anchanaa vaeyadaaniki clinical trial konasagutondi.

