
roganirodhaka sambandhita pratispandana pramaanaalu

roganirodhaka-sambandhita pratispandana pramaanaalu (irrc) anedi cancer rogulalo kanitulu merugupadinappudu ("pratispandinchandi"), adhe vidhamgaa unnappudu ("sthireekarinchandi") ledhaa chikitsa samayamlo marinta digajaarinappudu ("purogati") nirvachinche prachurinchina niyamaala samiti, ikkada moolyaankanam cheyabadutunna sammelanam immuno-oncology aushadham. cancer immunotherapy yokka vistruta rangamlo bhaagamaina immuno-oncologylo, cancertho pooraadataaniki sareeram yokka sonta roganirodhaka vyavasthanu upayoginchukune agentlu untaayi. saampradayakamgaa, kotta cancer chikitsalaku roogi pratispandanalu rendu setla pramaanaalanu upayoginchi anchanaa veyabaddaayi, avi ghana kanitulalo (parayana) pratispandana moolyaankanam pramaanaalu mariyu evaru pramaanaalu. roganirodhaka-sambandhita pratispandana pramaanaalu, 2009loe modatisaari prachurinchabaddaayi, roganirodhaka-oncology mandulu clinical trialslo viphalamavutaayani pariseelanalu nundi udbhavinchaayi, ivi pratispandanalanu evaru ledhaa receist pramaanaalanu upayoginchi kolustaayi, endukante eee pramaanaalu chaalaa mandhi rogulalo prarambha chikitsa mariyu kaniti bharanni tagginchadaaniki roganirodhaka vyavastha yokka spashtamaina charya madhya samaya antaraanni lekkinchalevu.
nepathyam.
clinical trialslo cancer nirodhaka agentla prabhavanni nirnayinche prakriyaloo bhaagamgaa atuvanti agentlu utpatti cheyagala kaniti kunchinchukupoye mottaanni kolavadam untundi. cancerku vyatiraekamgaa antarjaateeya union mariyu prapancha aarogya samstha 1970laloe abhivruddhi chesina hoo pramaanaalu, kaniti pratispandana moolyaankanam yokka krodeekarana kosam saadhaaranamgaa angeekarinchina modati nirdishta pramaanaalanu suuchistaayi. eee pramaanaalu modatisaarigaa 1981loe prachurinchabaddaayi. 2000loe modatisaari prachurinchabadina paatha pramaanaalu, parisoedhanaa samuuhaala madhya migili unna thedaalanu spashtam cheyadaaniki pradhanamgaa evaru pramaanaalanu savarinchaayi. receist kaniti parimaanam dvidisagaa kakunda ekadisagaa kolustaaru, takkuva gayalu kolustaaru, mariyu 'purogati' yokka nirvachanam maarchabadindi, tadwara idhi ikapai oke gaayam yokka vivikta perugudalapai aadharapadi undadu. kaniti pratispandana mariyu purogati yokka nirvachanaala kosam receist vaerae sankocham parimitini kooda sweekarinchindi. evarikosam idhi pakshika pratispandana kosam 50 saatam kante ekkuva kaniti kunchinchukupovadam mariyu pragatiseela vyaadhiki 25 saatam kante ekkuva kaniti perugudala anie pramaanam. parayana kosam idhi pakshika pratispandana kosam 30 saatam kante ekkuva kudinchadam mariyu pragatiseela vyaadhiki 20 saatam kante ekkuva perugudala. eee savaranalanninti yokka oka phalitam emitante, paatha pramaanaala prakaram 'purogati' gaa pariganinchabade ekkuva mandhi rogulu kotta pramaanaala prakaram 'pratispandakulu' ledhaa 'sthiramgaa' maararu. 2009 nundi receist mariyu daani varasudu, receist 1.1, ippudu cancer trialslo pratispandananu kolavadaniki praamaanika kolata protocol.
saitokinlu mariyu monoclonal antibodies vanti roganirodhaka vyavastha nundi pondina vividha cancer chikitsala adhyayanaalalo, chudabadina puurti mariyu pakshika pratispandanalato paatu sthiramaina vyaadhi kaniti bhaaram perigina tarvaata matrame sambhavinchindani, sampradaaya parayana pramaanaalu 'pragatiseela vyaadhi' anie pilavabadevi anie IRRC abhivruddhilo keelaka chodaka saktigaa undhi. praathamikamgaa, motaadu mariyu gamaninchina kaniti-nirodhaka tii sell pratispandana madhya alasyanni parigananaloki teesukovadamlo parayana viphalamaindi, tadwara 'vijayavantamaina' mandulu-antey, chivariki jeevitakaalam podiginchina mandulu-clinical trialslo viphalamayyayi. idhi cancer immunotherapy aasakti unna vividha parisoedhakulu mariyu aushadha developerlu, bristol-myers squib (bms) vadda axel hoose vanti roganirodhaka-oncology aushadhaala kosam pratyaekamgaa kotta pratispandana pramaanaalanu abhivruddhi cheyala vadda anae daanipai charchinchadam praarambhinchadaaniki daariteesindi. vaari aalochanalu, "journal off immunotherapy" loe 2007loe oka keelaka kaagitamlo modata flag cheyabaddaayi, roganirodhaka sambandhita pratispandana pramanaluga (irrc) parinaamam chendaayi, idhi 2009 chivarilo "clinical cancer research" jarnallo prachurinchabadindi.
pramaanaalu.
irrc developerlu vaari pramaanaala aadhaaramgaa evaru pramaanaalu aadhaaramgaa conny daanini savarinchaaruh
upayogaaniki rujuvu.
clinical cancer research" paperlo vivarinchina rendu dasalu II melanoma trialslo vaari pramaanaalu upayogakaramgaa unnayani IRRC srushtikartalu udaharinchina prarambha aadharalu unnaayi. pareekshinchabadutunna aushadham ipelimab anae monoclonal antibody, taruvaata vaidya seesamgaa axel hoosto bms vadda abhivruddhi chendutondi. eee aushadham tii sell activity yokka keelaka pratikuula niyantrakam anie piluvabade ctla-4 anae roganirodhaka tanikhi kendraanni lakshyamgaa chesukundi. ctla-4nii nirodhinchadam dwara, ipilimumab antitumer tii-sell pratispandanalanu saktivantam cheyadaaniki roopondinchabadindi. irrcni upayoginchi chikitsa pondina 227 mandhi rogulu mariyu moolyaankanam chesina rogulanu kaligi unna modati dasalo, eee rogulalo sumaru 10 saatam mandhi pragatiseela vyadhiga pariganinchabaddaaru, ayithe vaastavaaniki iplimamab pratispandanaku anugunamgaa irprs ledhaa irsdlanu anubhavinchaaru.
aipilimabto pootii padina pefizer yokka tremelimab anty-acla-4 monoclonal antibody yokka dasha III clinical vaiphalyam, irrc yokka upayogaaniki modati pedda ettuna sakshyalanu andinchindi. pefizer adhyayanam sampradaaya pratispandana pramaanaalanu upayoginchindi, mariyu prarambha madhyantara vislaeshanhaloo chikitsa pondina rogulaku manugada prayojanam ledani kanugonabadindi, idhi april 2008loe vichaarana mugimpuku daariteesindi.
 ayithe eee abhivruddhi jarigina oka samvatsaramlone, chikitsa mariyu niyantrana samuuhaala madhya manugada vakrarekhala vibajananu faizar parisoedhakulu gamaninchadam praarambhinchaaru. ipilimabab yokka pootiidaaru, ipilimabab, idhi irrcni upayoginchi moodava dasalo pareekshinchabadindi, 2011loe fda aamodam pondindi, idhi gurtinchaleni dasha III ledhaa IV melanomaku soochinchabadindi, 676-roogi adhyayanam taruvaata ipilimabab plus jipi 100 anae prayogaatmaka teekaanu teekaatho matrame polchindi. ipilimumab + teaca samuuhaaniki sagatu mottam manugada 10 nelalu kaga, teekaaku kevalam 6,4 nelalu matrame. yervayga vikrayinchabadina ipilimumab taruvaata bmsku blockbuster ayindi.
mukhya vyaktulu.
kotta irrcni vivarinchina 2009 paperlo pannendu mandhi rachayitalu unnaaru, veerandaroo udaaharanalugaa upayoginchina ipilimabab clinical trials thoo sambandham kaligi unnaaru-memorial sloan kettering cancer center yokka jedd volchok, axel hoose mariyu bristol-myers squib yokka rachel humphrey, shanta monika, sii. eah. looni angels clinic yokka steven oo 'day mariyu omid hummied., university off south florida yokka jeffrey webber, paarislooni hospital seyint-luis yokka selest leb, university hospital off siana yokka michel maayo, medical university off vienna yokka maikhel binder, perceptive informatics anie piluvabade berlin aadhaarita clinical informatics samstha yokka olivar bonsack, antibody injaneering company medarex yokka geophrey nikol (idhi modata aipilimabnu abhivruddhi chesindi) mariyu bostanloni danna-forber cancer institute yokka stephen hodi.