
pridnisone

pridnisone anedi roganirodhaka vyavasthanu anachiveyadaaniki mariyu ubbasam, cop, mariyu rheumatologic vyaadhulu vanti paristhitulalo vaapunu tagginchadaaniki ekkuvagaa upayoginche glucocarticoid aushadham. itara steroidlatho paatu cancer mariyu adrenal lopam kaaranamgaa adhika rakta calcium chikitsaku kooda dheenini upayogistaaru. idhi noti dwara teesukobadutundi.
deerghakaalika viniyogamtho saadhaarana dushprabhavalalo kantisuklaalu, emuka nashtam, sulabhamgaa gayapadatam, kandaraala balaheenata mariyu thrush unnaayi. itara dushprabhavalalo baruvu peragadam, vaapu, adhika raktamlo chakkera, sankramana pramaadam mariyu manasika rugmata vantivi untaayi. idhi saadhaaranamgaa garbhadhaarana samayamlo surakshitamgaa pariganinchabadutundi mariyu takkuva motaadulo tallipaalu icchinappudu surakshitamgaa kanipistundi. sudeerghakaalam upayoginchina tarvaata, pridnisone kramamga aapali.
pridnisone oka aushadham mariyu idhi churukuga maaradaaniki mundu kaaleyam dwara prednisolan gaa marchabadali. prednisolone appudu glucocarticoid graahakaalato bandhistundi, vaatini sakriyam chestundi mariyu janyu vyakteekaranalo maarpulanu prerepistundi.
pridnisone 1954loe patent cheyabadindi mariyu 1955loe united stateslo vaidya upayogam kosam aamodinchabadindi. idhi prapancha aarogya samstha yokka avasaramaina aushadhaala jaabitaalo undhi. idhi saadhaarana aushadhamgaa andubaatulo undhi. 2020loe, idhi 19 millionlaku paiga prescriptionlatho united stateslo 30va atyanta saadhaaranamgaa suuchimchabadina aushadham.
vaidya upayogaalu.
prednisone ubbasam, gout, cop, sid, rheumatic rugmatalu, allergy rugmatalu, ulcerative peddapregu shotha mariyu crone 's vyaadhi, paalii angitis thoo granulomatasis, adrenocartical lopam, cancer kaaranamgaa hyper calcemia, thyroid, lauringitis, teevramaina kshayavyadhi, daddurlu, taamara, lipid pneumonitis, pericardities, multiple sclerosis, nephrotic syndrome, sarcoidosis, shingles, lupus, mysthenia gravis, poison ook exposure, swayam pratirakshaka hepatitis, jaint-cellities, herksheimer vanti aneka swayam pratirakshaka vyaadhulu mariyu shotha paristhitulaku upayoginchabadutundi, idhi muscular regen, regen, mariyu orgaon regen, regen, regen, regen, regen, regen, regen, regen, regen, regen, regen, regen
migraine talanoppi mariyu cluster talanoppi chikitsalo mariyu teevramaina afthus alsar kosam kooda pridnisone upayoginchabadindi. pridnisone nuu antitumer aushadhamgaa upayogistaaru. teevramaina lymphoblastic leukemia, naan-hodkin lymphomas, hodgkins lymphoma, multiple myloma mariyu itara harmon-sensitive tumourla chikitsalo, itara cancer nirodhaka mandulatho kalipi idhi mukhyamainadi.
pridnisone tarachugaa aakasmika sensorinural vinikidi nashtam (ssnhechl) chikitsaku oka roopamgaa kooda suuchimchabadutumdi.
moothravisarjanaku moothrapindaala pratispandananu penchadaaniki kullina gunde vaiphalyam chikitsalo pridnisone upayoginchavacchu, mukhyamgaa loop mootravisarjana yokka pedda motaadulatoe vakreebhavana mootravisarjana nirodhakata unna gunde vaiphalyam rogulalo. eee prayojanam kosam charya yokka vidhanam paramgaah pridnisone, oka glucocarticoid, moothrapindaala lopali medullary sekarana naalamloo natriuretic peptide receptor rakam yokka saandratanu penchadam dwara karnika natriuretic peptideku moothrapindaala pratispandananu meruguparustundi, tadwara saktivantamaina moothravisarjananu prerepistundi.
adhika motaadulo, avayava marpidi taruvaata tiraskarananu nivaarinchadaaniki dheenini upayoginchavacchu.
dushprabhaavaalu.
anni glucocarticoids maadirigaane swalpakaalika dushprabhavalalo adhika raktamlo glucose sthaayilu (mukhyamgaa diabetes mellitus unna rogulalo ledhaa raktamlo glucosenu penche itara mandulu, tachrolimus vantivi) mariyu dravam nilupudala vanti mineralocarticoid prabhavalu untaayi. pridnisone yokka mineralocarticoid prabhavalu chinnavi, anduke marinta saktivantamaina mineralocarticoidnu ekakaalamlo nirvahinchakapothe, adrenal lopam nirvahanalo dheenini upayogincharu.
idhi kontamandilo niraasa ledhaa nispruha lakshanaalu mariyu aandolanaku kooda kaaranam kaavacchu.
deerghakaalika dushprabhavalalo cushings syndrome, steroid dementia syndrome, trunkle baruvu peragadam, glaucoma mariyu kantisuklaalu, diabetes mellitus rakam 2 mariyu motaadu taggimpu ledhaa viramanapai niraasa unnaayi. deerghakaalika steroidlu bolu emukala vyaadhi pramaadaanni kooda penchutaayi, ayithe eee vyaktulalo kondaru emukalanu rakshinchadaaniki mandulu teesukuntunnarani parisoedhanaloo telindi. pridnisone kooda leukocytosisku daariteestundi.
akasmaattugaa chevititanam ledhaa akasmaattugaa sensorinural vinikidi lopaniki chikitsagaa upayoginchinappudu, idhi tinnitus ledhaa chevulalo ringingnu kaliginchavacchu ledhaa teevrataram cheyavachu. 
majer.
moolamh
chinnadi.
moolamh
aadharapadatam.
edu rojula kante ekkuva kaalam pridnisone teesukunte adrenal anachiveta sambhavinchadam praarambhamavutundi. chivariki, idhi sareeram sahaja carticosteroids (mukhyamgaa cartisol) nuu tayaaru chese saamarthyaanni tatkalikamga kolpovadaniki kaaranam kaavacchu, dheeni phalitamgaa prednisonpy aadharapadatam jarugutundi. eee kaaranamgaa, edu rojulaku minchi teesukunte pridnisone akasmaattugaa aapakuudadu; badulugaa, motaadu kramamga tagginchaali. pridnisone yokka course takkuvagaa unte eee paalu vidichipettadam prakriya konni rojula paatu undavacchu, conny roogi deerghakaalika chikitsalo unte vaaralu ledhaa nelalu pattavacchu. aakasmika upasamharana anedi oka anubandha sankshobhaaniki daariteeyavachchu. deerghakaalika chikitsalo unnavaariki, pratyaamnaaya-roeju motaadu adrenal paniteerunu kaapaadutundi mariyu tadwara dushprabhaavaalanu taggistundi.
hypothalamous rendinti yokka pratispandananu nirodhinchadaaniki glucocorticoids panicheestaayi, carticotropin-vidudala chese harmon (siarhech) nuu taggistundi mariyu puurva petutory grandhiloo carticotrophes, adrenocarticotropic harmon (octhetch) mottaanni taggistundi. eee kaaranamgaa, prednisone vanti glucocarticoid analog mandulu glucocarticoids yokka sahaja samshlaeshanhanu niyantristaayi. eee vidhanam takkuva samayamlo aadhaarapadataaniki daariteestundi mariyu mandulanu chaalaa twaragaa upasamharinchukunte pramaadakaram kaavacchu. krah mariyu aakt yokka samshlaeshanhanu praarambhinchadaaniki mariyu adrenal grandhulu mallee saadhaaranamgaa panicheyadam praarambhinchadaaniki sariiraaniki samayam undaali.
pridnisone aneka vaaraala paatu 7-10 mg ledhaa anthakante ekkuva motaadulo upayoginchinatlayithe hypotholomic-petutory-adrenal (HPA) aksham anachiveyadaaniki daariteeyavachchu. idhi pratiroojuu sareeram utpatti chese endogenous cartisol mottaaniki daadaapu samanam. anduvalla, hetch. pii. eah. aksham anachiveyabadatam mariyu ksheeninchadam praarambhistundi. idhi sambhavinchinatlayithe, adrenal grandhi daani paniteerunu mariyu steroidla antarjana utpattini tirigi pondadaaniki taginanta samayanni ivvadaaniki rogiki nemmadigaa pridnisone tagginchaali. adhika sthaayi ottidini edurkontunna hetch. pii. eah. aksham anachiveta unnavaarilo anubandha motaadulu ledhaa "ottidi motaadulu" avasaram kaavacchu (udhaa.zii.anaaroogyam, shastrachikitsa, gaayam modalainavi.). atuvanti paristhitulalo alaa cheyadamlo viphalamaithe praanaalaku muppu yerpadavachhu.
upasamharana.
carticosteroid upasamharanalo motaadu taggimpu yokka parimaanam mariyu vegaanni cases-bye-cases praatipadikana nirnayinchaali, chikitsa pondutunna antarleena paristhitini parigananaloki teesukoovaali mariyu punaraavrutamayye sambhaavyata mariyu carticosteroid chikitsa vyavadhi vanti vyaktigata roogi kaarakaalanu parigananaloki teesukoovaali. vyaadhi tirigi vachhe avakaasam laeni mariyu kaligi unnavaarilo systemic carticosteroids yokka kramamga upasamharananu pariganinchaalih
vyaadhi tirigi vachhe avakaasam laeni mariyu moodu vaaralu ledhaa anthakante takkuva kaalam chikitsa pondina mariyu paina vivarinchina roogi samoohaalalo cherchabadani vaarilo systemic carticosteroids akasmaattugaa aagipovachhu.
carticosteroid upasamharana samayamlo, motaadu vaegamgaa saareeraka motaadulaku tagginchavachhu (rojuvaaree prednisolone 7.5 mii. graa. kuu samanam), aapai marinta nemmadigaa tagginchavachhu. tirigi sambhavinchakundaa chusukovadaniki upasamharana samayamlo vyaadhi yokka anchanaa avasaram kaavacchu.
aushadha shaastram.
pridnisone anedi daani shotha nirodhaka mariyu roganirodhaka saktini tagginche lakshanaala kosam upayoginche synthetic glucocarticoid. pridnisone anedi oka prodrug; idhi kaaleyamlo 11-beata-hcsd dwara kriyaaseela aushadhamaina prednisolone varaku jeevakriya cheyabadutundi. hepatic metabolism dwara pridnisolonga marchabade varaku pridnisone gananeeyamaina jeeva prabhavalanu kaligi undadu.
pharmacokinetics.
prednisone jeernasayaantara pregullo soshinchabadutundi mariyu 2 nundi 3 gantala sagam jeevitakaalam kaligi untundi. idhi 0.4-1 l/kilola pampinhee parimaanaanni kaligi undhi. cytochrome pii450 enjaimlanu upayoginchi hepatic metabolism dwara eee aushadhaanni tolagistaaru. upajeevakriyalu pittam mariyu moothramlo visarjinchabadataayi.
lodotra.
"lodotra" anedi noti suutreekarana yokka brand paeru, idhi teesukunna naalugu gantala tarvaata pridnisone vidudala chestundi. idhi udayam drudhatvamtho rheumatoid artharaitisku suuchimchabadutumdi. 10 pii vadda teesukunnaru.emm.idhi sumaru 2 a vadda aushadhaanni vidudala chestundi.emm.. plaasmik garishta sthaayi 4 a vadda cherukuntundi.emm.idhi udayam bigutu nundi upasamanam pondadaaniki saraina samayamgaa pariganinchabadutundi. eee aushadhaanni 2009 janavarilo european unionlo aamodinchaaru.
parisrama.
aushadha parisrama united states pharmacopia (yuu. ess. pii) prakaram raddu pareeksha parikaraala kramaankanam kosam pridnisone maatralanu upayogistundi.
chemistry.
pridnisone anedi cartisone yokka synthetic pregnane carticosteroid mariyu utpannam mariyu dheenini δ1-cartisone ledhaa 1,2-dehydrocartisone ledhaa 17α, 21-dihydroxypregna-1,4-daine-3,11,20-trion anie kooda pilustaaru.
charitra.
pridnisone mariyu prednisolan yokka modati isolation mariyu structure identifications 1950loe orther nobil chetha cheyabaddaayi. 1955loe shering corporation prayogasaalalo prednisone yokka modati vaanijyaparamgaa saadhyamayye samslaeshanha jarigindi, idhi taruvaata orther nobil mariyu sahodyogulache shering-plau corporationga maarindi. cartisone suukshmajeevasaastraparamgaa prednisone gaa "corinabacterium simplexes" anae bacteria dwara aakseekaranam cheyabadutundani vaaru kanugonnaru."hydrocartisone nundi prednisolone tayaareeki adhe prakriyanu upayoginchaaru.
cartisone mariyu hydrocartisone meeda eee sammelanaala merugaina adrenocorticoid charya elukalalo pradarsinchabadindi.
pridnisone mariyu prednisolan 1955loe shering mariyu apjon dwara varusaga meticarten mariyu delta-cartef anae brand paerlatoe pravesapettabaddaayi. eee prescription mandulu ippudu aneka tayaareedaarula nundi generic aushadhaalugaa andubaatulo unnaayi.

