leukosidine

leukosidine anedi konni rakaala bacteria ("stephylococcus") dwara srushtinchabadina cytotoxin rakam. idhi oka rakamaina randhraalanu yerparuchukune vishamu. randhraala erpadataaniki namuunaa dasala vaareegaa untundi. modata, cytotoxin yokka "s" upa vibhagam nirdishta protein kaligina grahakaalu ledhaa host sell uparitalampai oka integrinnu gurtistundi. S sub unit appudu rendava, "f" sub unitnu niyamistundi mariyu rendu sub unitlu host sell uparitalampai dimerise avtayi. dimerisation tarvaata, oligomerization jarugutundi. chivaraga, pratyaamnaaya s mariyu f upabhaagaalato kuudina oligomerlu, gananeeyamaina nirmaana maarpuku lonavutaayi mariyu beata-byaarelnu yerparustaayi, idhi host sell yokka lipid dvipadaram gundaa kuttutundi.
("-side") leukocytelanu champadam dwara leukosidinlu vaati paerlanu pondutaayi. leukosidines phagocytelu, sahaja killer kanaalu, dendritic kanaalu mariyu tii lymphocytelanu lakshyamgaa chesukuntaayi, anduvalla sahajamaina mariyu anukuula roganirodhaka pratispandanalu rendintinee lakshyamgaa chesukuntaayi. leukosidinlu bacteria invassin vargamloki vastaayi. invaasinulu anevi enzymatic sraavaalu, ivi bacteria avi jatacheyabadina atitheya kanajaalampai daadi cheyadaaniki sahaayapadataayi. exotoxinla maadirigaane unnappatikee, invaasinlu rendu vidhaluga bhinnamgaa untayih avi exotoxinla kante chaalaa takkuva nirdishta vidhaanaala dwara panicheestaayi mariyu vaati charyalu saadhaaranamgaa marinta sthaanikeekarinchabadathaayi.
oka rakam panton-valentin leukosidine.

