
com keey 2

calcium/kaalamodulin-aadhaarita protein kines kines 2 anedi maanavulalo "kaamk 2" janyuvu dwara encode cheyabadina enjaim.
function.
eee janyuvu yokka utpatti serin/thraeonine-nirdishta protein kines kutumbaaniki chendinadi, mariyu CA + +/kaalamodulin-aadhaarita protein kines upakutumbaaniki chendinadi. eee protein diguva kinases kaamk1 mariyu kaamk4lanu phosphorylate cheyadam dwara calcium/kaalamodulin-aadhaarita (com) kinace cascadelo paatra poeshistumdi, idhi vaati utpreraka charyanu penchutundi. camca 1 mariyu camca 4 varusaga thurr 177 vadda mariyu thurr 196 vadda phosphorylated cheyabaddaayi.
com keey 2 akalini prerepinche harmon neuropeptide vai utpattini niyantristundi mariyu hypothalamuslo ampic kinesga panichestundi. diguva sanketha maargaalanu tagginchadam mariyu myuu opioid grahaka niyantrana tagginchadam dwara hyperalgesia mariyu opioid analgesic aushadhaalaku sahanam abhivruddhilo kooda idhi mukhyamaina paatra poeshistumdi. elukalalo kaamk 2 nirodhinchadam valla aakali taggutundi mariyu baruvu taggadaanni prothsahistundi.
com keey 2 medadulooni vividha praantaalalo aneka vidhulanu kaligi undhi. hippocompuslo, neuronal cytoskelitanlo abhyasa-prerita nirmaana maarpula niyantrana dwara ghnaapakasakti erpadataaniki kaamk 2/kaamk 1 cascade avasaram. hippocompasloni dendritic vennemukalalo padanirmaana maarpulu-ivi ca1 pyramid neuronlalo synaptic plaastisitiini praarambhinchadaaniki mariyu nirvahinchadaaniki avasaram-ghnaapakaalu erpadataaniki pradhana nirmaanaatmaka aadharam.
kaamk 2/comkive/creb cascade anedi prasavaanantara cerebellum abhivruddhilo paalgontundi. com keey 2 tolagimpu anedi bahya kana pora (egl) loe vistarinchadaanni aapi, antargata kana poraku valasa vellae kana kana puurvagaamula (gcps) saamarthyaanni nirodhinchadam dwara-mastishka kanamlo atyanta samruddhiga unde kanaala-cerebellar kana kanaala abhivruddhini balaheenaparustundi. eee samalakshanam taggina bdnf vyakteekarana mariyu taggina creb phosphorylationto kooda mudipadi untundi. anduvalla, sii. zii. sii. abhivruddhi yokka mukhyamaina dasanu puurti cheyadaaniki prasavaanantara cerebellumlo bii. dii. enn. eff (medadu nundi utpannamaina neurotrophic karakam) utpattiki kaamk2/comkive/creb cascade avasaram. neuronal com keey 2 yokka bdnf niyantrana iteevala glioblastoma purogatiki kaaranamaindi.
hypothalamuslo, kaamk2 anedi ampkay/β mariyu ca2 +/com thoo signalling complexenu erpaatu cheyadam dwara kendra madhyavartitva shakti homeostasislo paalgontundi. com keey 2 yokka janyu ablation hypothalamuslo ampic charyanu taggistundi mariyu enn pii ii neuronlalo enn pii ii mariyu aggar pii janyu vyakteekarananu niyantristundi, idhi aaharam-prerita oobakaayam, hyperglycemia mariyu insulin nirodhakata nundi elukalanu rakshistundani choopabadindi. adanamgaa, madhya hypothalamuslo saraina saanubhooti kaaryakalaapaalaku avasaramaina janyuvula janyu niyantranalo kaamk 2 paalgontundi, anduvalla emuka dravyarashi cherutundi, idhi saanubhooti swaramtho pratikuulamgaa mudipadi undani cheppavacchu.
isopharmlu.
eee janyuvu kosam aaru vibhina isopharmlanu encoding chese edu transcript vaeriyantlu gurtinchabaddaayi. adanapu splies vaividhyaalu vivarinchabaddaayi conny vaati puurti-nidivi swabhaavam nirnayinchabadaledu. gurtinchina isopharmlu autophosphorylationku gurayye mariyu diguva kainesesnu phosphorylate chese pratyeka saamarthyaanni pradarsistaayi.