
kull1

kullin 1, dheenini kull 1 anie kooda pilustaaru, idhi kullin kutumbaaniki chendina maanava protein mariyu janyuvu.
eee protein protein ksheenata mariyu protein sarvavyaaptilo mukhyamaina paatra poeshistumdi.
idhi ess. sii. eff (eskipi1-kull1-eff-baaks protein) ii3 ubiquitin ligase complexelo oka mukhyamaina bhaagam, idhi kana chakram purogati, signal transduction mariyu transcriptionlo palgone proteinla sarvavyaaptiki madhyavartitvam chestundi. scf complexelo, idhi eskipi1-eff-baaks protein mariyu arbx1 upabhaagaalanu nirvahinche drudamaina paranjaga panichestundi. uparitalam mariyu ubiquitin-samyoga enjaim sthaanaanni yerparachadam dwara utpreranaku dohadam cheyavachu.
eee protein kull1, arbx1, eskipi1 mariyu eskipi2 latho kuudina scf complexelo oka bhaagam. idhi rnf7 thoo kooda sankarshana chendutundi. tip120eah/cand1 mariyu arbx1 thoo kuudina complexelo bhaagam. undedilated roopam tip120eah/cand1 thoo sankarshana chendutundi mariyu paraspara charya scf complexeloni eskipi1 thoo anubandhaanni pratikuulamgaa niyantristundi. pooliisulatoe sambhaashistundi.
idhi oopiritittula fibroblastlalo vyakteekarinchabadutundi.
protein neddylated, idhi scf yokka sarvavyaapta karyakalapalanu penchutundi. cop9 signalosome (csn) complexto daani paraspara charya dwara dendylite cheyabadindi.