
maanavulalo intragenomic mariyu intravatorine sangharshana

maanavulalo tallulu mariyu vaari santaanam madhya janyuparamaina mariyu garbhasayamloni gharshanalu talettutaayi. tallidandrulu andinche pettubadi yokka saraina mottampai tallidandrulu mariyu vaari santaanam tarachugaa vibhedistaarani tallidandrula pettubadi siddhaantam perkondi. endukante tallidandrula uttama prayojanaalu ellappuduu santaanam yokka uttama prayojanaalato saripoladam ledhu. talli santhaanamlo talli pettubadi teevrata kaaranamgaa talli-sisuvu sangharshana aasakti kaligistundi. maanavulalo, pillalu swayam samruddhi chendadaaniki mundu sudeergha abhivruddhi kaalam kaaranamgaa tallulu tarachugaa tama pillalaku samvatsaraala tarabadi samrakshananu istaaru.  
tallidandrulu mariyu vaari pillalu saadhaaranamgaa oka sahakaara udyamamlo nimagnamai untaaru, dheenilo santaanam manugada mariyu bhavishyat punarutpatti dwara iddaroo prayojanam pondutaaru. ayithe, vaati janyuvulu okela lenanduna vaati aasaktulu okela undavu. tallidandrulu mariyu santaanam iddaroo tamaku taamugaa sambandham kaligi unnappatikee, vaaru tama janyuvulalo 50 saatam matrame okaritho okaru panchukuntaaru, antey tallidandrulu mariyu pillalu iddaroo konnisaarlu okaritho okaru vibhedistaaru. 
garbhaasayamlo sangharshana.
talli-sisuvu sangharshana garbhadhaarana samayamlo praarambhamavutundi, ikkada talli sareeram abhivruddhi chendutunna pindam kosam kooda andistuunee thana aarogyaanni kapadukovali. sthuulamgaa, pindam mariyu talli rendintikee pindam kaalaaniki raavadamlo mariyu aarogyakaramaina puttukaku daariteese parinaamaatmaka aasaktulu oke vidhamgaa untaayi. ayithe, pindam pondadaaniki ishtapade poeshakaala parimaanam mariyu talli ivvadaaniki ishtapade mottam madhya kooda vibhedaalu undavacchu. udaaharanaku, pindam perugudalanu evaru niyantrinchaalanae daanipai talli mariyu pindam madhya vivaadam undavacchu, indulo pindam saraina perugudalanu ishtapadutundi mariyu talli thana vadda unna vanarula sthaayiki sambandhinchi pindam perugudalanu niyantrinchadaaniki ishtapadutundi. 
maavi yokka paatra.
maavi eee sangharshanhalo mukhyamaina paatra poeshistumdi, endukante idhi talli nundi pindaaniki poeshaka pampinheeki muulam, mariyu talli mariyu pindam rendinti nundi sankethaalanu kooda pondutundi. talli mariyu pindam madhya sangharshanhalo maavi samatulya paatra pooshistundani nammutaaru, talli vanarula labhyata yokka abhivruddhi parimitulanu batti pindaaniki saraina fitnessnu andistundi. udaaharanaku, rutherford mariyu tardiff, maarutunna chettha parimaanaalatoe kuudina marmosetlalo, moodu chettalu maavi yokka chinna vaataalato mudipadi unnayani suuchimchaaru, pindam yokka saamarthyaanni penchagaligaayani suuchistumdi, bahusha garbham yokka nirmaanaanni marchadam dwara mariyu adanapu talli vanarulanu abhyardhinchadaaniki, parimita talli vanarula kosam pindaala madhya pootiini edurkontunnappudu. edemaina, vijayavantamaina garbhadhaarana mariyu puurti moodu chettalanu vidichipettadam arudugaa undatam valla pindam saamarthyam kosam oka yantraangam unnappatikee, talli yantraamgaalu saktivantamaina pettubadulanu, mukhyamgaa puttina taruvaata, parimitam cheyavachani suuchistumdani kooda vaaru gamaninchaaru. 
garbhasayamloni mariyu janyusambandhamaina sangharshana rendintikee sambandhinchina oka mukhya aavishkarana emitante pindam janyuroopam talli sareeradharma saastraanni prabhaavitam cheyagaladu. talli endometrium yokka pindam taarumaaru pindam talli dhamani raktaanni pondadaaniki anumatistundi. eee taarumaaru dwara, talli tanaku taanugaa rakta pravahanni parimitam cheyakunda pindaaniki rakta pravahanni parimitam cheyadu. pindam maarpula nundi tallulu rakshinchalekapoyinappudu, garbhadhaarana madhumeham mariyu prii-eclampsia vanti garbhadhaarana sambandhita syndromela abhivruddhi sambhavistundi. pindam-prabhaavita insulin nirodhakataku pratispandanagaa adhika raktamlo glucose insulin utpattini penchinappudu garbhadhaarana madhumeham sambhavistundi. prii-eclampsia anedi garbhadhaarana samayamlo sambhavinche adhika raktapotu, idhi pindam yokka taarumaaru phalitamgaa rakta pravahanni penchutundi.
janyu mudra.
janyu mudra anedi okari talli ledhaa tandri nundi janyuvu vaarasatvamgaa vachinda anae daanipai aadharapadi oke janyuvu yokka vividha prabhavalanu suuchistumdi. chaalaa janyuvulu vaati tallidandrula muulam aadhaaramgaa ververu prabhavalanu kaligi undakapoyina, oka chinna upasamiti chestundi. eee janyuvulanu mudrinchinavigaa suuchistaaru. santhaanamlo janyuvu yokka vyakteekarana prabhavam tallidandrula aarogyampai balamaina prabhavanni choope avakaasam unnappudu mudra erpadutundi. udaaharanaku, talli nundi vanarulanu santaanam pondadamlo chikkukunna janyuvulu tandri aarogyaaniki balamgaa prayojanakaramgaa untaayi, endukante talli vanarulanu pondadamlo atyanta vijayavantamaina janyuvulanu kaligi unna athani santaanam manugada saaginchi punarutpatti chese avakaasam undhi. antekakunda, sisuvuku tallipaalu ivvadaaniki tandri etuvanti pratyaksha kharchunu chellinchadu, ayithe talli kharchu chellistundi. eee sandarbhamlo, eee janyuvula talli coppy kante ekkuva vanarulanu pondadaaniki eee janyuvula tandri kaapeeni enchukoovaali. prastutam, elukalalo sumaru 100 mudrinchina janyuvulu mariyu maanavulalo 50 unnaayi. konni mudrinchina janyuvulu etuvanti prabhavanni chuupadam ledhu, ledhaa janyuvu paniteeruku spashtamgaa sambandhinchinatlayithe janyuvu yokka mudrinchina vyakteekarana undadu. 
garbhasaya sangharshana maadirigaane, janyu mudrana maavi thoo chaalaa sambandham kaligi untundani nammutaaru, endukante janyu mudranaku aadharalu garbhagudi ksheeradaalalo matrame kanipistaayi, idhi janyu mudrana mariyu maavi parinaamatmakamgaa mudipadi unnayane parikalpanaku daariteestundi. mudrinchina janyu vyakteekarana maavi yokka saadhaarana abhivruddhi mariyu paniteerulo antarbhaagamgaa choopabadindi. inca, pindam, maavi mariyu talli hypothalamous madhya vyakteekarinchabade signalling yokka web pindam perugudala mariyu medadu abhivruddhiki sambandhinchina janyu vyakteekarana yokka saha-anusaranala phalitamgaa undavacchu. 
mudrana rugmatalu.
janyu mudrana drugvishayam yokka aavishkarana, praadar-villie/angelman syndromelu, beckwith-wideman syndrome mariyu sylver-russell syndrome vanti aspashtamaina vaarasatva namuunaalatoe aneka rugmatalaku aadharaanni ardham chesukovadaniki parisoedhakulaku sahaayapadindi. mudrinche rugmatalu asaadhaarana dna methylationku sambandhinchinavigaa bhaavistaaru, indulo bahula mudrinchina lokey undavacchu. sahayaka-punarutpaadaka saanketikata mariyu talli aaharam vanti peri-conceptional environmental karakalu mudrana-sambandhita rugmatalalo chikkukunnayani rujuvulu andakosa aarogyam mariyu saraina mudrana abhivruddhi madhya sambandhaanni geestaayi. 
praadar-villie syndrome mariyu angelman syndrome.
praadar-villie mariyu angelman syndromelu anevi janyu rugmatalu, ivi mudrinchina janyuvu yokka ekaika coppy 'nissabda' coppy ayinappudu mariyu kriyaaseela coppy lenappudu, tolagimpu ledhaa yeka parental dsomy kaaranamgaa sambhavistaayi. rendoo 15q11-q13 vadda janyu vyakteekarana lekapovadam valla, indulo praadar-villie pitrutvaparamgaa utpannamaina janyuvu lekapovadaanni pratibimbistumdani nammutaaru, mariyu angelman syndrome talli coppy lekapovadam pratibimbistumdi. 
praadar-villie syndrome vishayamlo, talli 'nissabda' coppy undagaa, tandri coppy undadu. praadar-villie syndrome anedi takkuva janana baruvu, adhika somnolens, takkuva aakali mariyu paelavamaina peelchukovadam dwara vargeekarinchabadutundi. pillavadu saadhaaranamgaa 1 nundi 2 samvatsaraala vayassulo vipareetamaina akalini abhivruddhi chestaadu, idhi saadhaaranamgaa prarambha oobakaayaaniki daariteestundi. praadar-villie syndrome unna pillalu saadhaaranamgaa balyam antataa mariyu yuktavayassu perugudala lenappudu etthu taggutaaru. 
bandhutva siddhaantam.
janyu mudranu adhyayanam cheyadaaniki upayoginche oka namuunaa bandhutva siddhaantam. sisuvulo pitru mariyu maatru janyuvula prayojanaala madhya vibhedaala kaaranamgaa, mukhyamgaa shishu talli vanarulanu upayoginchadaaniki sambandhinchi mudrinchadam parinaamam chendutundani bandhutva siddhaantam vaadistundi. tallulu ververu tandrulanu kaligi unna pillalanu kaligi undavacchu, anduvalla pitrutva-utpanna janyuvulu santaana perugudalaku anukuulamgaa talli vanarulanu dopidi chestayani bhaavistunnaaru, ayithe prasuuti-utpanna janyuvulu bahula santhaanamlo vanarulanu vyaapti cheyadaaniki talli vanarula ketaayimpunu parimitam chestayani bhaavistunnaaru. 
bandhutva siddhaantam dwara, pitrutvam nundi utpannamaina janyuvu lekapovadam valla praadar-villie syndrome sambhavistundani siddhaantam cheyabadindi, mariyu prasuuti 'nissabda' coppy matrame coppy. eee sandarbhamlo, parinaama charitralo talli kharchulanu tagginchina pravartanalanu pillavadu vyaktam cheyaalani bhaavistunnaaru. mukhyamgaa, sisuvu thana talli nundi talli paalapai puurtigaa aadhaarapade samvatsaraalalo sisuvuku aaharam ivvadaaniki pratispandanalu taggadam mariyu takkuva aakali anedi tallulu tama vanarulanu tamalo taamu mariyu bahula santaanam kosam ketaayinchadaaniki veelu kalpistundi. sisuvuku tallipaalu ivvadaaniki rojuku adanamgaa 500 kilola kharchu avtundani anchanaa veyabadindi, chanubalivvadam samayamlo adanapu saktini viniyoginchakapothe, boddy storelanu upayoginchadam valla tallipaalu ivvadam anedi khareedaina talli prayatnamgaa maarutundi. chinna vayassulo takkuva aakali taruvaata akasmaattugaa aakali mariyu tine pravartanalu 2 samvatsaraala vayassulo praarambhamavutaayi. saampradaaya jeevanaadhaara samajalalo, idhi pillalaku talli paalu nundi paalu vidichipetti, anubandha ghana aaharalanu andinche vayassuku anugunamgaa untundi. eee aahara padaarthaalanu sekarinchadam valla tallipaalanu ivvadam kante eee paalu vidichipettadam valla talliki pratyakshamgaa takkuva kharchu ayye avakaasam undhi, endukante eee aahara padaarthaalanu sekarinchadam valla aame sekarinchadaaniki takkuva kharchutho kuudukunnadi, ledhaa aaharaanni sekarinchadamlo aameku sahaayapadataaniki aame saamaajika bhaagaswaamulapai aadhaarapadavachhu. anduvalla, puurveekula tallidandrula ketayimpu sangharshanhalaku sambandhinchi talettina saadhaaranamgaa adrushya mudrinche prabhaavaala paatralanu chuudataaniki praadar-villie maaku anumatistundi. saadhaaranamgaa abhivruddhi chendutunna vyaktulalo, praadar-villie mariyu angelman syndromeku sambandhinchina mudrinchina janyuvulu sahaja empika dwara roopondinchina "rappimpu-yuddhamlo" samatulyata kaligi untaayi. ayithe, eee janyuvulalo okati lenappudu samatulyata debbatintundi mariyu eee rugmatalalo kanipinche samalakshanhaalaku phalitamgaa prabhavalu erpadataayi. 
rutuvirati.
prarambha samayamlo vaividhyam mariyu rutuvirati yokka lakshana vyakteekarana janyuvulalo sangharshananu suuchimchavachchani kontamandi rachayitalu vaadinchaaru. maanava stree punarutpatti saamarthyam 50 samvatsaraala vayassulo mugustundi, idhi vaidya samrakshana andubaatulo laeni samaajaalato sahaa mahilala anchanaa jeevitakaalam kante rendu dasaabdaala mundugaane untundi. rutuvirati enduku udbhavinchindani chaalaa mandhi prasninchaaru, endukante ruthuvirathini anubhavinchani mahilalu tama punarutpatti saamardhyaalanu vistarinchadam dwara mariyu ekkuva mandhi pillalanu kaligi undatam dwara tama aarogyaanni penchukoogalugutaaru. ammamma parikalpana prakaram rutuvirati anedi abhivruddhi chendindi, endukante idhi sammilita fitness dwara stree yokka fitnessnu penche anusarana, idhi aame manumalu vanti aame bandhuvula dwara aame janyuvulanu prothsahistundi. rutuvirati praarambhaaniki sambandhinchina empika saktulu tandri mariyu talli aasaktula madhya bhinnamgaa undavacchu. puurveekula vaataavaranaalaloo stree-pakshapaata chedaragotte namoonaalalo paryaavarana vyatyaasaalu rutuvirati prarambham mariyu rogalakshana shaastram gurinchi janabha madhya prastuta vyatyaasaaniki sambandhinchinavi kaavacchu. alaa ayithe, chedaragottadamlo takkuva stree pakshapaatam unna janabhalo puurveekulu abhivruddhi chendina mahilalu, chedaragottadamlo adhika stree pakshapaatam unna janabhalo puurveekulu abhivruddhi chendina mahilala kante marinta teevramaina lakshanaalanu mariyu mundastu ruthuvirathini anubhavinche avakaasam ekkuvagaa untundi.