
thromboragulation

raktam gaddakattadam anedi praathamika gaddakattadam elaa niyantrinchabadutundani yantraamgaala shreni. eee vidhanalalo pootii nirodham ledhaa pratikuula pratispandana untaayi. indulo praadhamika haemostasis untundi, idhi rakta plateletlu gayapadina rakta naalaala endothelianiki elaa kattubadi untayane prakriya. raktanaalaala nashtanni saricheyadaaniki mariyu raktam thrumbus erpadataaniki platelet aggregation praadhamikamainadi. gaddalanu tolaginchadam kooda thromboragulationlo bhaagam. platelet gaddakattadam niyantranalo vaiphalyam raktasraavam ledhaa raktam gaddakattadaaniki kaaranam kaavacchu. thromboragulatorlu anie piluvabade padaarthaalu eee sanghatanala yokka prati bhaganni niyantristaayi.
praathamika haemostasis inducerlu.
raktam gaddakattadam yokka oka praathamika pani praathamika haemostasis yokka niyantrana, idhi platelet aggregation prakriya. konni thromboragulatorlu platelet agregationnu meruguparustaayi mariyu marikonni eee prakriyanu nirodhistaayi. phalitamgaa vachhe thrumbus yokka puttukalo platelet aggregation keelaka paatra poeshistumdi. antukune prakriya sthaanikamgaa undaali, conny platelet trumbus erpadataaniki mariyu rakta nashtam nivaarinchadaaniki platelet aggregation vipareetamgaa peragali. platelet aggregation karakalu antukune vidhananni penche niyantrakaalu mariyu plateletlanu daani kanajalalanu sravinchadaaniki prerepistaayi. naalapu endothelial kavarku gaayam ayina tarvaata bahirgatamayye collagen, platelet antukune mariyu daani kriyaaseelataloo agonistga aadutundani choopabadindi. upa-endothelial kollajenku plateletlanu bandhinchadam valla platelet kanajaalaalo unde ADP, txa2 mariyu serotonin sraavam prerepistundi.
ADP-aadhaarita aggregation rendu graahakaala dwara madhyavartitvam cheyabadutundihi purinergic p2y1, gαq thoo jatacheyabadi, plateletla nirmaanamloo aakaraanni madhyavartitvam chestundi mariyu aggregation prakriyanu prerepistundi. raktapotu kriyaaseelataloo thromboxane eah2 (tx2) saanukuula pratispandananu kaligi untundi. idhi rendu enjaimla dwara arachidonic aamlam yokka oxygenation dwara utpatti avtundi cycloxygenase mariyu thromboxane eah2 synthase. tx2 prabhavalu g protein-coupled grahakaalu, uparakaalu tpα mariyu tpβ dwara madhyavartitvam cheyabadataayi. rendu grahakaalu phospholipase sii uddeepanaku madhyavartitvam chestaayi, deenivalla innocital 1,4,5-trifasphate mariyu diasylglycerol yokka kanaantara sthaayilu perugutaayi. innocital 1,4,5-trifasphate anedi CA gaadata perugudalaku kaaranamavutundi mariyu diasylglycerol vidudala pkcని sakriyam chestundi. tpα shibira sthaayilanu prerepistundi, ayithe tpβ kanaantara shibira sthaayini nirodhistundi. serotonin, 5-hetch. tii, anedi pegullo samslaeshanha cheyabadina amine, idhi prii synaptic neuronlu ledhaa enterochromaphine kanaala uddeepananu sakriyam chesina tarvaata raktapravaahamloki vidudala cheyabadutundi. taruvaata, idhi antidepressant-sensitive 5-hetch tii transporterlanu (serts) upayoginchi plateletla dwara vaeru cheyabadutundi mariyu vesicular monoamine transporter (vimat) dwara platelet yokka kanikalaloki vaeru cheyabadutundi. sraavam taruvaata, 5-hetch tii 5-hetch tii 2 graahakaalato bandhinchadam dwara prothrombotic agentla prabhavalanu penchutundi. 
praathamika haemostasis inhibitors.
praathamika haemostasis nirodham anie piluvabade gadda tolagimpu prakriyanu niyantrinche baadhyata kooda thromboragulationku untundi. eee inhibitorlu platelet antukupovadaanni nivaarinchadam dwara gaddakattadanni nirodhinche padaarthaalu. raktam gaddakattadam ledhaa raktam gaddakattadanni nivaarinchadaaniki mariyu tatphalitamgaa gundepotu mariyu strokelanu nivaarinchadaaniki platelet nirodham mukhyam. konni praathamika haemostasis inhibitorlu camp, prostassiclin, pge1 mariyu kistrin. camp, cyclic adenosine monophosphate, protein kines eah (pica) dwara phosphorylate sandesavaahakulu. eee signalling moolakaalalo thromboxane a2, grahaka rakam α, phospholipase cβ3 mariyu ip3 grahakaalu unnaayi. shibira sthaayilalo plateletlalo sanketeekarana chaalaa sunnitamainadi. naitrik oxide (ledhu) cgmp utpattini prerepistundi, anduvalla cgmp-aadhaarita protein kines (zii kines) nuu sakriyam chestundi. eee kines gαq-phospholipase sii-innocital 1,4,5-trifasphate signalingnu nirodhistundi mariyu thromboxane A2 kosam kanam lopala calcium sameekarananu nirodhistundi. pgi2, prostassiclin, shibiram erpadataanni utprerakam chese aipi graahakaalato bandhistundi. eee prakriya gtp-binding protein gs mariyu adenilyl cyclays dwara madhyavartitvam cheyabadutundi. pge1 anedi IP graahakaalato bandhistundi. aipi grahakaalu eah. dii. pii mariyu serotonin sraavam prerepinche ayanophorlatho bandhistaayi. pge1 pootii nirodham dwara platelet agregationnu prerepinche kaarakaala sraavam nirodhistundi. kistrin anedi platelet aggregationku protein inhibitor. idhi glycoprotein aib-aiya antagonistla yokka homolagus kutumbaaniki chendinadi. kistrin jipi aib-III thoo bandhinche oka antukune pradaesaanni kaligi undhi.

