phoneutria nigreventor taxin-3

phoneutria nigreventor taxin-3 nuu saadhaaranamgaa Phtx3 anie pilustaaru.
Phtx3 neurotoxin anedi oka vistruta-spectrum calcium chaanal blocker, idhi glutamate vidudala, calcium teesukovadam mariyu sinaptosomlalo glutamate teesukovadam kooda nirodhistundi. prastutam, idhi sahajamgaa saaleedu "phoneutria nigreventor" yokka vishamlo matrame sambhavistundani telisindi, dheenini brazilian alert spider anie kooda pilustaaru.
chaduvulu.
eee neurotoxinpy aneka adhyayanalu jarigaayi, veetilo okati 3 hetch-acetylcholine vidudalapai daani prabhaavaaniki sambandhinchi, mariyu okati "phoneutria nigreventor" upayoginche itara vishapadaarthaalatho prabhavanni polchadam.
maroka adhyayanam eee krindi vaadanalu chesindi neurotoxins neurotransmissionlo palgone yantraamgaalanu ardham chesukovadaniki sahaayapadataayi. saaleedu phoneutria nigreventor yokka visham nundi pondina rendu neurotoxin isopharmlu, yokka mariyu mariyu, teella visham titustoxin dwara prerepinchabadina eluka cartical sinaptosomlalo 45 yokka + pravahanni nirodhinchaayani memu ikkada nivedistunnamu. tx3-3 mariyu tx3-4 kosam IC50 varusaga 0.32 mariyu 7.9 nm. neurotoxins yokka mariyu mariyu 45 yokka + pravahanni nirodhinchadamlo chaalaa prabhaavavantamgaa untaayi mariyu avi yokka +-aadhaarita prakriyalatho kuudina adhyayanaalalo upayogapadataayi.
universidade federal dii minas geroys vadda chesina oka adhyayanam ilaa perkondih vishapuurita bhinnam, phoneutria nigreventor taxin-3 taxin-3, yokka +-aadhaarita glutamate vidudalanu raddu chesindi, conny eluka medadu cartical sinaptosomlanu 33 mm kcl thoo vidhvamsam chesinappudu glutamate yokka yokka +-swatantra sraavamnu maarchaledu. eee prabhavam chaalaa varaku voltage-gated calcium chaanalla dwara calcium pravesamlo jokyam kaaranamgaa undavacchu, endukante PHtx3 pora vidhvamsam dwara prerepinchabadina intracyanaptosomal free calcium perugudalanu 50 saatam tagginchindi mariyu calcium ianophore (ianomycin) dwara prerepinchabadina glutamate vidudalanu prabhaavitam cheyaledu. Phtx3 bhinnamlo unde polypeptide (tx3-3) transmitter vidudalapai Phtx3 bhinnam mariyu takkuva nanomolar paridhiloo intracyanaptosomal free calcium yokka prabhavalanu punarutpatti chesindi. memu yokka dwara utpatti cheyabadina maarpulanu exocytosisto paatu calcium chaanellanu nirodhinche vishapadaardhaala charyalatho polchamu glutamate vidudala mariyu intracyanaptosomal calcium yokka yokka nirodham doubleu-conotoxin emvik thoo gamaninchinatlugaa unnatlu phalitaalu suuchimchaayi. tx3-3 anedi glutamate exocytosisnu nirodhinche calcium-chaanal virodhi anie memu suuchistunnaamu.

