
isrib

isrib (integrated stress response inhibitor) anedi 5 nm yokka aisi 50 thoo if2α phosphorylation yokka prabhavalanu tippikotte oka prayogaatmaka aushadham. shaan franciscoloni california vishwavidhyaalayamloni peater walter prayogasaalalo chinna anuvula pedda libraryni paakshikamgaa svayamchaalakamgaa pareekshinchadam dwara dheenini kanugonnaru, carmela sidrousky daanipai parisoedhana cheyaalani nirnayinchukunnaaru. idhi if2α phosphorylation-prerita ottidi kanajaalam (esgy) erpadataanni nirodhistundani choopabadindi. eif2α phosphorylation ghnaapakasakti nirmaanamloo paalgontundi kabatti, idhi "inn vivo" loe churukuga untundaa anie telusukovadaaniki isrib pareekshinchabadindi mariyu enimidi gantala sagam jeevitamto rakta-medadu addankini sulabhamgaa daatutundani kanugonabadindi.
2013loe jarigina tadupari pareekshalo, praamaanika neeti-chittadavi mariyu conditioned environment pareekshalalo praadaesika mariyu bhayam-sambandhita abhyasanni meruguparachadam dwara kolichinatlugaa, elukalalo gananeeyamaina nootropic prabhavalanu utpatti cheyagaladani kanugonnaru.
eee saanketika parignaanam 2015loe kaalikoku licenses pondindi mariyu isrib aadhaaramgaa saadhyamayye aushadhaalanu kanugonadamlo sahaayapadataaniki sidrouskeeni niyaminchaaru. daanini adhyayanam chestunna prayogasaalaku aame naayakatvam vahistunnaaru.
2017loe jarigina pareekshalo, prayogaatmaka aushadham medadulo gayapadina elukala ghnaapakasakti pareekshalalo ghnaapakasaktini neerchukunee mariyu roopondinche saamarthyaanni meruguparichindani, tadwara baadhaakaramaina medadu gaayam nundi balaheenatalanu tippikottela kanipistundi. isrib chikitsa praadaesika ghnaapakasakti lopaalanu kooda sarichestundi mariyu vruddha elukalalo pani ghnaapakasaktini meruguparustundi.
sidrouski chesina aushadhampai tadupari parisoedhanaloo, baadhaakaramaina medadu gaayaala tarvaata elukalalo ghnaapakasaktini anuvu punaruddharinchindani telindi. idhi algimers, parkinsons mariyu lou gehrig vyaadhi (amyotrophic lateral sclerosis ledhaa alls anie kooda pilustaaru) vanti neurodegenerative vyaadhulaku chikitsa cheyagala saamarthyaanni kooda choopinchindi. elukalalo, idhi vayassu-sambandhita abhignaa ksheenatanu tagginchindi mariyu aarogyakaramaina elukalaku merugaina ghnaapakasaktini ichindi. sidrousky chesina isrib paie parisoedhana kaalikolo konasagutondi.