paatu

cellular retinoic assid-binding protein 1 anedi maanavulalo "crob 1" janyuvu dwara encode cheyabadina protein.
retinoic aamlam-madhyavartitva bhedam mariyu vistarana prakriyalalo kanaalalo mukhyamaina paatra pooshistundani bhaavistaaru. idhi nirmanatmakamga cellular retinol-binding proteinlanu pooli untundi, conny retinoic aamlanni matrame bandhistundi. paatu anedi rajyangaparamga vyakteekarinchabadutundi mariyu sambandhita sambandhita kante kanamlo vibhina vidhulanu kaligi untundani nammutaaru.
function.
paatu retinoid aamlamtho bandhistundi mariyu daanini kendrakamloki ravana cheyadaaniki sahaayapadutundi (chitram 1). kanaalalo mariyu mariyu rendoo eee kaaryaacharananu nirvahistaayi. retinoic aamlam anuvu appudu vidudala cheyabadutundi mariyu retinoic aamlam grahakam (rar) mariyu retinoid x grahakam (rxr) homodymerlu ledhaa heterodymerluga bandhinchabadutundi. eee sanklishtata taruvaata retinoid aamlam aadhaarita shoonya janyuvula pratilekhanaanni niyantrinche dnapy retinoic aamlam pratispandana muulakaalatoe (arudaina) bandhistundi. nuclear localization mariyu retinoic assid binding kosam domainlu chitram chitram chuupabaddaayi.
paatu bahula cancer vistarana margalalo paalgontunnatlu kanugonabadindi. kanaalalo kana chakramlo palgone extracellular signal-regulated kines, kines mariyu mariyu kineslanu sakriyam chestundi. kanaalalo charya tadwara kana chakranni vistarinchagaladu, udhaa.zii. pinda mariyu naadii muula kanaalalo. paatu laeni nakout elukalu neural stem sell vistarananu penchaayi, tadwara hippocompus neurogenesisnu choopinchaayi. antekakunda, morris water maze test mariyu object recognition task dwara kolichinatlugaa, nakout elukalalo abhyasam mariyu ghnaapakasakti meruguparachabaddayi.
paatu cancer sell apoptosislo kooda paalgontundi. trans-retinoic aamlam paatu yokka ligandga [cancerku shoonya chikitsa lakshyamgaa] pariganinchabadindi. paatu niyantrinche kines/2) idhi cancer kanaala apoptosisnu prerepinche mariyu pinda muula kanaala kana chakranni podiginche protein phosphatase 2eah 2eah nuu sakriyam chestundani gamaninchabadindi. pp2a kaaryaacharana bheda prakriya samayamlo muula kanaala punaruddharana saamarthyaanni prothsahistundi. paatu padipoyinappudu apoptotic prerana saamarthyam kooda tolaginchabadindi mariyu kana vistaranaku anumatinchabadindi. kanaalalo shoonya kanaalalo kanaalalo yokka punah vyakteekarana prerita apoptotic charyanu tirigi teesukuvacchindi. anduvalla cancer kanaalalo apoptotic karyakalapala kosam cross-retinoic aamlamtho paatu paatu nuu chikitsa lakshyamgaa upayoginchavacchu. kanaala vistarana mariyu apoptotic karyakalapala kosam peethatho bandhinche retinoic aamlam yokka rendu maargaalanu chitram 2 vivaristundi.

