pemolin

pemolin, silert anae brand paerutoe vikrayinchabadutundi, idhi oka uddeepana aushadham, idhi attension-deficit hyperactivity desorder (ADHD) mariyu narcolepsy chikitsalo upayoginchabadutundi. kaaleya vishapuuritatoe arudaina conny teevramaina samasyala kaaranamgaa idhi chaalaa deshaalalo nilipiveyabadindi. eee aushadhaanni noti dwara teesukunnaru.
pemolin yokka dushprabhavalalo nidralemi, aakali taggadam, kadupu noppi, chiraaku mariyu talanoppi unnaayi. arudugaa, eee mandulu teevramaina kaaleya nashtanni kaligistaayi, idhi kaaleya marpidi ledhaa maranaaniki daariteeyavachchu. pemolin oka psychostimulent mariyu empika chesina dopamine reaptake inhibitor mariyu vidudala agentga panichestundi. anduvalla, idhi dopamine graahakaala paroksha agonistga panichestundi. pemolin norpinefrinepy takkuva prabhavanni chooputundi, anduvalla aneka itara uddeepanalaku bhinnamgaa, hridayanaala ledhaa saanubhooti prabhavalanu takkuvagaa ledhaa yea vidhamgaanuu kaligi undadu.
charitra pemolin samslaeshanha cheyabadindi, conny 1930la varaku uddeepanakaarigaa kanugonabadaledu mariyu 1975 varaku ADHD chikitsalo upayoginchabadaledu. 1997 mariyu 2005 madhya united statesto sahaa aneka deshaalalo kaaleya vishapuuritam kaaranamgaa idhi upasamharinchabadindi. ayithe, idhi japaanlo narcolepsy chikitsa kosam ADHD kosam upayoginchina daanikante takkuva motaadulo andubaatulo undhi. pemolin anedi itara uddeepana mandulatho sambandham mariyu durviniyogaaniki avakaasam unnanduna united stateslo schedule IV niyantrita padaardham. itara uddeepana mandula kante idhi takkuva durviniyoga saamarthyaanni kaligi unnatlu telustondi.
vaidya upayogaalu.
adhd mariyu narcolepsy chikitsalo pemolin upayoginchabadindi. idhi pagatipuuta adhika nidra chikitsalo kooda upayoginchabadindi. eee aushadhaanni saadhaaranamgaa ADhd chikitsalo rojuku okasari 18.75 nundi 112.5mg motaadulalo upayoginchaaru, chaalaa mandiki samarthavanthamaina motaadu 56.25 nundi 75mg paridhiloo untundi. pemolin charya kramamga praarambhamavutundi mariyu chikitsaatmaka prayojanaalu upayogam yokka moodava ledhaa nalgava vaaraala varaku sambhavinchakapovachhu. idhi 37.5mg yokka takkuva prarambha motaadu mariyu aneka vaaraala paatu motaadulo kramamga paiki peragadam valla kaavacchu.
andubaatulo unna faaraalu.
pemolin 18.75,37.5, mariyu 75mg noti takshana-vidudala maatralu (silert) alaage 37.5mg noti takshana-vidudala namalagala maatrala roopamlo andubaatulo undhi. idhi pradhanamgaa free bays roopamlo conny magnitium uppugaa kooda andinchabadindi.
dushprabhaavaalu.
pemolin yokka dushprabhavalalo nidralemi, aakali taggadam, kadupu noppi, chiraaku mariyu talanoppi unnaayi. idhi athi takkuva hridaya sambandha ledhaa saanubhootigala dushprabhaavaalanu kaligi untundi. amphetamines mariyu methylphenidate vanti shaastreeya uddeepanala kante pemolin takkuva-saamarthyam/telikapati uddeepanagaa varninchabadindi mariyu vaati kante takkuva dushprabhaavaalanu kaligi untundani chebutaaru.
kaaleya vishapuuritam.
arudugaa, hepatotoxicityki kaaranamayye pemolin chikkukuntundi. eee kaaranamgaa, daanitoe chikitsa pondina vaariki kramam tappakunda kaaleya pareekshalu nirvahinchaalani fda sifaarsu chesindi. pravesapettinappati nundi, idhi kaneesam 21 kaaleya vaiphalya kesulato mudipadi undhi, veetilo 13 kaaleya marpidi ledhaa maranaaniki daariteesaayi. eee aushadhaanni teesukune rogulalo daadaapu 1-2% kaaleya transominage enjaimla adhika sthaayilanu chooputundi, idhi kaaleya vishapuuritataku oka marker, ayithe teevramaina kesulu chaalaa arudu. united states mariyu kenadaalo matrame sumaru 25 samvatsaraalalo ADHD thoo unna 200,000 mandiki paiga pillalu pemolin suuchimchabaddaaru, inca takkuva sankhyalo peddalu dheenini itara suuchanala kosam suuchimchaaru (mariyu migilina prapanchamlooni prescriptionlatho sahaa kaadu). anduvalla, ganankaparamga kaaleya vaiphalyam kesula sankhya antha peddadi kaadu. ayithe, praticharyalu vilakshanhamainavi mariyu anuuhyamainavigaa niroopinchabaddaayi, rogulu konnisaarlu nelalu ledhaa samvatsaraalu kooda etuvanti samasya lekunda aushadhaanni teesukuntu, akasmaattugaa teevramaina kaaleya vishapuuritatanu abhivruddhi cheyadaaniki mundu. spashtamaina bahirgatam-vishapuurita sambandham ledhu, mariyu kaaleya pathology yokka lakshanaala kanugonabadaledu. kontamandi rogulu modati sariga kanipinchina kaamerlu mariyu puurti kaaleya vaiphalyam madhya oka vaaram kante takkuva samayam unnatlu chuupimchaaru, mariyu kaaleya vaiphalyam abhivruddhi chendina kontamandi rogulu intaku mundu pareekshinchinappudu perigina kaaleya transominess sthaayilanu choopinchaledu. marovaipu, japaanlo pemolin thoo sambandham unna kaaleya vaiphalyam kesulu laevu, ayinappatikee idhi takkuva motaadulo upayoginchabadutundi mariyu eee desamlo narcolepsy yokka samuchita suuchana kosam matrame suuchimchabadutumdi.
adhika motaadu.
pemolin adhika motaadu choreoathetosis lakshanaalatoo undavacchu.
paraspara charyalu.
itara uddeepanalu mariyu monoamine accidase inhibitorlu pemolin thoo viruddhamgaa untaayi.
aushadha shaastram.
pharmacodynamics.
pemolin yokka pharmacodynamics sarigga ardham kaaledu mariyu daani khachitamaina charya yokka vidhanam khachitamgaa nirnayinchabadaledu. ayithe, pemolin itara psychostemulantla maadirigaane kaaryaacharana mariyu prabhavalanu kaligi untundi, mariyu jantuvulalo eee aushadham dopamine reaptake inhibitor mariyu vidudala agentga panichestundi. medadulo dopamine sthaayilanu penchadam dwara, idhi dopamine graahakaala paroksha agonistga panichestundi. chaalaa itara uddeepanalaku bhinnamgaa, pemolin gananeeyamaina kendra ledhaa paridheeya noradrenergic prabhavalanu utpatti cheyadu. phalitamgaa, idhi hridayanaala ledhaa saanubhooti prabhavalanu takkuvagaa ledhaa yea vidhamgaanuu kaligi undadu. pemolin anedi dopamine vidudalanu balaheenamgaa prerepinche empika chesina dopamine reaptake inhibitorga varninchabadindi.
dextroamphatomine mariyu methylphenidate vanti mandulu schedule II gaa vargeekarinchabaddaayi mariyu gananeeyamaina durviniyoga sambhaavyatanu kaligi undagaa, pemolin schedule IV (naan-narcotic) gaa jabita cheyabadindi. praimetlapai nirvahinchina adhyayanaalalo, pemolin sweeya paripalanaku saamarthyaanni pradarsinchadamlo viphalamavutundi. idhi durviniyogam mariyu aadhaarapadataaniki takkuva sambhaavyatanu kaligi undani bhaavistunnaaru. edemaina, itara manasika uddeepana mandulatho saaruupyata kaaranamgaa siddhaantaparamgaa durviniyogam jaragavacchu.
pharmacokinetics.
maanavulalo pemolin yokka pharmacokinetics adhyayanalu chaalaa parimitam. pemolin garishta sthaayiki 2 nundi 4 gantala samayam untundi. garishta sthaayilu 2 nundi 4.5μg/ml paridhiloo unnatlu nivedinchabadindi. pemolin yokka sthiramaina-sthithi sthaayilu 2 nundi 3 rojullo cherukuntaayi.
pemolin gananeeyamaina plasma protein binding ledhaa 50 saatam plasma protein binding kaligi undadani vividha rakaluga nivedinchabadindi.
pemolin kaaleyamlo jeevakriya cheyabadutundi. dheeni gvakriyalo pemolin conjugate, pemolin dione, mandelic aamlam mariyu gurtinchabadani dhruva gvakriyalu unnaayi.
pemolin pradhanamgaa moothrapindaala dwara visarjinchabadutundi, sumaru 50 saatam maarani roopamlo visarjinchabadutundi mariyu jeevakriyagaa chinna mottamlo matrame untundi. pemolin yokka tolagimpu sagam jeevitam 7 nundi 12 gantalu. pillalalo sagam jeevitam 7 gantalu, conny vayassu perige koddi 11 nundi 12 gantalaku peragavacchu. pemolin yokka saapekshamgaa sudeergha ardha-jeevitam rojuku okasari ivvadaaniki anumatistundi.
saampradaaya maatralu, mingagalige namile maatralu ledhaa namile maatralatho pemolin yokka pharmacokineticslo etuvanti thedaalu kanipinchaledu.
rasayana shaastram.
pemolin 4-oxazolidinone taragatilo sabhyuralu mariyu aminorax, 4-methylaminorex, chlominorex, cyclazodone, phenozolone, fluminorex mariyu thozalinone vanti taragatiloni itara sabhyulatho nirmanatmakamga sambandham kaligi untundi.
upayogamlo unna pemolin lavanaalu pemolin magnitium (free bays conversion ratio. 751), pemolin iron (. 578), pemolin copper (. 644), pemolin nickel (. 578), pemolin rubedium, pemolin calcium, pemolin chromium mariyu paina perkonna chelates, ivi baruvulo perkonna upputho samanamga untaayi. pemolin rahita ksharamu mariyu pemolin cobalt, strontium, sylver, barium, lithium, sodiyam, potassium, jink, manganese mariyu seesiyam anevi parisoedhana rasayanalu, veetini prayogaala kosam oke chota utpatti cheyavachu. pemolin serium vanti lanthanide pemolin lavanaalu vanti itara padaarthaalanu tayaaru cheyavachu; pemolin beryllium bahusha vishapuuritam kaavacchu.
charitra.
charitra pemolin mottamodata samslaeshanha cheyabadindi, conny 1930la varaku daani kaaryaacharana kanugonabadaledu. kanugonabadaledu united stateslo ADHD chikitsa kosam pemolin aamodinchabadindi.
pillalu mariyu koumaaradasalo pemolinku sambandhinchina teevramaina kaaleya vishapuuritam mariyu sambandhita maranam yokka kesulu 1977 mariyu 1996 madhya united states phud und drugg administration yokka medwatchku nivedinchabaddaayi. pemolin thoo teevramaina kaaleya vishapuuritam modatisaarigaa 1984 mariyu mariyu vaidya saahityamlo editarku raasina lekhalalo vivarinchabadindi. 1990la varaku pemolin thoo kaaleya vishapuuritam gurinchi vaidyulaku peddagaa teliyadu. pemolin kosam kaaleya vishapuuritam kosam heccharikalu december december united states phud und drugg administration (fda) lebulku jodinchabaddaayi mariyu juun juun vraatapuurvaka sammati mariyu kaaleya enjaimla tarachugaa paryaveekshanha avasaraalatoe paatu block baaks heccharika jodinchabadindi. eee heccharikalu heccharikalu pemolin thoo kaaleya vishapuuritatvampai prachurananu anusarinchaayi. ayithe, vaidyulu pemolin vaadakampai fda aadesaalanu sarigaa paatinchaledani phalitaalu suuchimchaayi. edemaina, united stateslo pemolin ammakalu 1997 varaku perigayi mariyu 1996 mariyu 1999 madhya taggai. united kingdamlo 1997 septembarulo, kenadaalo 1999 septembarulo mariyu united stateslo 2005 septembarulo kaaleya vishapuuritam kaaranamgaa pemolin upasamharinchabadindi. abbat prayogasaalalu 2005 maeloe united states market nundi swachchandamgaa pemolinnu upasamharinchukunnaayi mariyu 2005 novemberlo fda generic pemolin aamodaanni upasamharinchukundi. 2017 natiki narcolepsy chikitsa kosam japaanlo pemolin andubaatulo undhi.
samajam mariyu samskruti.
paerlu.
"pemolin" anedi aushadham yokka saadhaarana paeru mariyu daani, mariyu.
pemolin gatamlo silert, beatonamine, seractive, hyperylex, kethamade, ronil, stimul, tamilan, traden, troposure mariyu valital anae brand paerlatoe vikrayinchabadindi.
labhyata.
pemolin united states, kenada, united kingdom, belgium, luxemberg, speyin, germany, switzerland mariyu argentinalo vikrayinchabadindi. idhi 2017 natiki narcolepsy chikitsa kosam japaanlo andubaatulo undhi. ayithe, eee aushadhaanni japaanlo arudugaa upayogistunnatlu chebutaaru, endukante narcolepsy anedi oka samuchita suuchana mariyu vaidyulu kaaleya vishapuuritam gurinchi jagrattagaa untaaru.
chattaparamaina sthithi.
cycotropic padaarthaalapai sampradaayam prakaram, idhi schedule IV niyantrita padaardham. pemolin anedi 1530 da yea. sii. ess. sii. enn thoo schedule IV naan-narcotic (stimulent) niyantrita padaardham mariyu vaarshika tayari kotalaku lobadi undadu.
parisoedhana.
alasata.
multiple sclerosis mariyu hechaivi-sambandhita vyaadhi kaaranamgaa alasata chikitsalo pemolin prabhaavavantamgaa untundani nivedinchabadindi.

