
ilana bii. telivigaa

ilana bii. whitten oka american neuro scientist mariyu prinsetton vishwavidhyaalayamlo manastatvasaastram mariyu neurosines professor. reward learning mariyu nirnayam teesukoovadaanni nadipinche straital neural circuit mechanismlapy drushti saarinchi, mesolymbic marganni vitten adhyayanam chestaadu.
prarambha jeevitam mariyu vidya.
whitten newjerseelooni prinsetonlo perigaaru, akkada aame tallidandrulu iddaroo prinsetton vishwavidhyaalayamlo professorlugaa unnaaru. aame tandri edward whitten saiddhaantika bhouthika shaastravetta mariyu prinsetton vishwavidhyaalayamlo ganitasastra professor, mariyu aame talli chiara nappi bhouthika shaastra professor. whitten thana swasthalamaina prinsetton unnata paatasaalalo chadivi, aapai thana under graduate vidya kosam intiki daggaragaa prinsetton vishwavidhyaalayamlo chadivindi. whitten sodari daniela whitten stanford vishwavidhyaalayamlo ganitam mariyu jeevasaastramlo under graduate degreeni abhyasinchaaru.
prinsetton vadda, bhouthika saastramlo praaveenyam sampaadinchindi, conny aame under graduate degree samayamlone aame jeevasaastram, mukhyamgaa neurosines patla aakarshituraalaindi. prinsetonlo thana modati samvatsaramlo, whitten lii merril sylver prayogasaalalo parisoedhanaa sahayakudiga panicheesaaru, molecular biology mariyu janyusaastram adhyayanam chesaaru. taruvaata thana under graduate degreelo, whitten maikhel zhe yokka prayogasaalalo cheraaru. berry, akkada aame ganana naadii saastramlo thana under graduate thesis kosam parisoedhana nirvahinchindi. aame under graduate anners thesis "testing pharr metabolic efficiency inn dhi neural code off dhi retina" anae sheershikato roopondinchabadindi, dheeniki bhouthika shaastra vibhagam avaardu ichindi. whitten eah thoo pattabhadrudayyaadu.bii. 2002loe prinsetton vadda bhouthikashaastramlo patta pondaaru.
thana under graduate parisoedhanaa anubhavaala nundi prerana pondina whitten 2003loe stanford vishwavidhyaalayamlo neurosciencelo thana graduate vidyanu abhyasinchindi. eric nudsen maargadarsakatvamlo, whitten gudlagoobala kendra naadii vyavasthalo neurobiological mechanisms off attension und strategies off information prosessingnu anveshinchindi.
baarn gudlagoobalalo indriya samachara prosessing.
anchanaa anedi maarutunna mariyu anischita vaataavaranaalaku tagina pravartanaa pratispandanalanu madhyavartitvam cheyadaaniki medadu nirvahinche praathamika naadii ganana. whitten yokka prarambha graduate paniloo, baarn gudlagoobaloni oka nirdishta neural circuit chalana shravana uddeepanala sthaanaanni elaa anchanaa vestundo aame anveshinchindi. optical tectum anedi giddangi gudlaguba medadulooni oka praantam, idhi gudlagoobalanu shravana uddeepana vaipu chuudataaniki sahaayapadutundi, mariyu shravana vyavastha nundi samacharanni encoding chese neuronla dwara shravana sthalam yokka sthalaakruthi myapnu roopondinchadaaniki idhi praarambhinchabadutundi. shravana uddeepanalu kadulutunnappudu eee sthalaakruthi patam elaa maarutundo ardham chesukovalanukunnadu. shravana grahana kshetraalu uddeepana sthaanamtho padunugaa mariyu marutayani aame kanugondi, shravana kshetraalu shravana uddeepanala sthaanaanni track cheyadaaniki bhavishyat maarpulanu chestayani choopistundi.
vividha rakaala indriya uddeepanalu mariyu vividha maargaala nundi samacharanni ekikrutam cheyalsinappudu medadu oka yeka vastuvunu elaa gurtistundo anveshinchadaaniki whitten aasakti chuupaadu. hebbian plasticity namuunaanu upayoginchi, medadulo antarleenamgaa unna synaptic plasticity anedi vastuvunu gurtinchadam mariyu praatinidhyam anedi oka rakamaina input yokka praadaesika praatinidhyaalalo vyatyaasam valla marokadaaniki sambandhinchi erpadutundani whitten pratipaadinchaaru. indriya input yokka prati chaanelku plasticity mottam aaa chaanelku grahana kshetram yokka balam mariyu vedalpupai aadharapadi untundani aame kanugondi. plaastisiteeki maarganirdesam chese balamaina inputlatho, idhi medadulo samalekhana indriya praatinidhyaala abhivruddhi mariyu nirvahanaku kaaranamavutundi.
reward circuitlanu vichchinnam cheyadaaniki optogeneticsnu upayoginchadam.
2008loe thana Phdని samarthinchukunna taruvaata, carle diseroth prayogasaalalo post doctoral adhyayanalanu nirvahinchadaaniki whitten stanfordlone undipoyindi. diceroth maargadarsakatvamlo, neural circuitlalo janyuparamgaa nirvachinchina kana rakalanu vichchaedimchae optogenetic saanketika parignaanaanni elaa upayoginchaalo whitten neerchukunnaadu, mariyu medadu yokka reward circutrylo colinergic neuronlu whitten yokka pratyeka aasakti. 2010loe prachurinchabadina sains loe modati rachayita kaagitamlo, nucleus akumbenslo colinergic neuronla paatranu vichchinnam chesaaru, ivi sthaanika neuronlalo kevalam 1 saatam matrame unnappatikee, circuitaryni mariyu driving pravartananu modulate cheyadamlo mukhyamaina paatra poeshistaayi. eee colinergic interneuronelu kokain paripalana dwara sakriyam cheyabaddaayani, ayinappatikee vaatini nissabdam cheyadam valla naclo madhyastha vennemuka neuron karyakalapalu perugutaayani, elukalalo kokain conditioningnu nirodhistundani aame kanugondi. pravartanaa phalitaalanu madhyavartitvam cheyadamlo neuronla yokka intha chinna janabha pooshinchagala keelaka paatranu whitten kanugonnaru.
striatum merugaina aushadha-prerita conditioninglo colinergic interneuronlanu nirodhinchadam valla, whitten mariyu diceroth nac ledhaa striatamloni colinergic interneuronlalo optogenetic saanketika parignaanaanni upayoginchadaaniki petentnu daakhalu chesaayi. elukala namoonaalalo bahumati pravartanalu mariyu vyasananni baga ardham chesukovadaniki modata saanketika parignaanaanni upayoginchaalani, taruvaata stiritamloki opsin encoding polynucleotidelanu ivvadam dwara maanavulalo vyasana rugmatala chikitsalo nirdishta neural circuitlanu lakshyamgaa chesukovalani vaaru pratipaadinchaaru. optical ledhaa electrical stimulation dwara, eee saanketikata vyasanamtho badhapaduthunna vaariki tatkalikamga-khachitamaina chikitsa vyuuhaalanu praarambhistundi.
appudu whitten naraala reward circuitaryni anveshinchadaaniki eluka namuunaalaku optogeneticsnu vartimpajeyaalanukundi, kabatti aame elukalalo th:: cree mariyu chaatah: cree driver linelanu srushtinchindi. eee kotta driver lainlatho, eluka medadulo cree-dependent opsinlanu vyakteekarinchadaaniki, dopamine neuron firing mariyu aame kotta raetu driver linelalo saanukuula upabalaala madhya kaarana sambandhaanni spashtam cheyadaaniki, endipoyina injection vairaslu. crit elukalalo uttejaka jatarika tegmental praantam dopamine neuronlu intracronial sweeya-uddeepananu utpatti chesayani whitten dhruveekarinchaaru, idhi optogeneticsnu upayoginchi elukalalo nirdishta naadii circuitlanu vichchaedimchae aame sadhanam yokka saktini highlight chesindi, idhi gatamlo saadhyam kaadu.
whitten stritumlo colinergic circuitlanu mariyu diceroth lablo thana kalamanta reward pravartanalanu nadapadamlo dopamine neuronla paatranu anveshinchadam konasaaginchindi mariyu prayogasaalalo thana naalugu samvatsaraala padaveekaalamlo aneka patraalapai saha rachayitagaa maarindi.
vrutti mariyu parisoedhana.
diceroth prayogasaalalo post doctoral pani taruvaata, prinsetton neurosines institute mariyu psychology vibhaagamlo psychology mariyu neurosines assistant professorga maaradaaniki 2012loe prinsetton vishwavidhyaalayaaniki whitten niyaminchabaddaadu. whitten prinsetton vadda thana prayogasaalanu praarambhinchindi mariyu elukala namoonaalalo reward learning mariyu nirnayam teesukovadamlo neural circuitlanu anveshinchadaaniki ankitam cheyabadindi. optogenetics, elukala pravartana, electrophysiology, imaging mariyu computational modeling vanti paddhatulanu upayoginchadam dwara, whitten mariyu aame brundam striatal mariyu itara reward circutory drive pravartanalanu andinche kotta vidhaanaalanu kanugonagalugutaru. 2018loe ilana associate professorga padoonnati pondaaru mariyu prinsetton vishwavidhyaalayamlo padaveekaalam manjuru cheyabadindi.
pradhana parisoedhakudigaa thana paathratho paatu, whitten pni graduate vidyaarthi pravaesaala kamiteelo sabhyuralu, pni vesavi karyakramam kosam urmlanu enchukune kamiteelo sabhyuralu, graduate vidyaarthi paatyaamsaalanu punahroopakalpana chese kamiteelo sabhyuralu, alaage aame prinsetton neurosines communityki maddatugaa aneka itara kamitee paatralu.  whitten prinsetton vadda aneka taragatulaku kooda bodhistaadu mariyu nirnayam teesukovadamlo working memory paniteeru elaa aadhaarapadutundo ardham chesukovadaniki 7-lyab nih nidhulatho kuudina project ayina brain cogs (abhignaa vyavasthala circuitlu) loe sabhyudu.
reward circuitaryni vichhedanam cheyadam.
2016loe, prinsetanloni whitten mariyu aame brundam vaari straital target region dwara nirvachinchabadina midbrine dopamine neuronla yokka vividha janabha yokka vibhina vidhulanu pariseelistuu oka kaagitaanni prachurinchaaru. ventral stritumku project chese dopamine neuronlu pratiphala viniyogaaniki balamaina pratispandanalanu kaligi unnayani mariyu dorsomedial stritumku project chese dopamine neuronlu viruddha empikalaku balamgaa spandistaayani vaaru kanugonnaru. rendu upa janabha reward-prediction errarnu pradarsinchinappatikii, whitten yokka anveshanalu vibhina dopamine terminal input sthaanaalu stritumloni function yokka specialisationku maddatu istayani chuupistunnaayi.
reward learninglo chikkukunna straital neuronlanu adhyayanam cheyadam konasaagistuu, colinergic straital interneuranlapy thana post doctoral pani nundi vaari kaaryaacharana profiles, synaptic plasticity mariyu reward learning madhya sambandhaanni parisoedhinchadaaniki whitten tirigi vachindi. colinergic neuronla charya antarinchipovadaanni niyantristundani neerchukunna kokain-sandarbha sambandha sanghaalanu whitten mariyu aame brundam kanugonnaru. inca, colinergic neuronlu striatum yokka medium spiny neuranlaloki presinaptic glutamatergic inputlo nirantara taggimpuku madhyavartitvam chestaayi. eee pani modatisaarigaa, striatumlo colinergic interneuronla modulatory paatranu highlight chesindi.
circuitlu saamaajika mariyu praadaesika samacharanni encoding chestaayi.
saamaajika paraspara charya antargatamgaa bahumatigaa unnanduna, dopaminergic reward vyavasthalo saamaajika samachara prosessingnu ardham chesukovadam chuttoo thana parisoedhanaa kaaryakramamlo kontha bhaganni roopondinchadaaniki whitten aasakti choopindi. 2017loe, whitten mariyu aame brundam nucleus acumbens (nac), amigdala mariyu ventral tegmental praantaaniki project chese saamaajika pravartanalo chikkukunna prelympic (pl) cartical neuronla yokka pratyaekamaina upasamitini anveshinchaaru. aasaktikaramgaa, pl-nock projection kriyaaseelakam saamaajika praadhaanyata taggadaaniki daariteestundi, kabatti aame brundam eee projection yea samacharanni teliyajestundo ardham chesukovadaniki prayatninchindi. saamaajika pravartanaku maarganirdesam cheyadaaniki saamaajika-praadaesika sanghaala erpaatuku veelu kalpinche praadaesika mariyu saamaajika samacharam rendintinee idhi teliyajesindani vaaru kanugonnaru.
vibhina dopamine neuron encoding.
vitten mariyu aame sahacharulu appudu vii. tii. eah looni dopaminergic neuronlanu marinta kathinamgaa pareekshinchaaru. eee neuronlu reward circutrytho pramaanikamgaa sambandham kaligi unnappatikee, avi aneka itara pravartanaa chararaasulaloo chikkukunnayi, kabatti reward, reward predicting suuchanalu, reward charitra, praadaesika sthaanam, kinematics mariyu pravartanaa empikanu encode cheyagala vaati saamarthyaanni chuudataaniki vitten aasakti chuupaaru. inn vivo calcium imaging dwara, whitten mariyu aame brundam reward anubandha mariyu reward kaani anubandha chararaasulatoo anubandhinchabadina vita daa neuronla kriyaatmaka samuuhaalanu kanugonnaru, mariyu eee neuronlu kooda vita lopala praadesikamgaa samuuhimchabaddaayi.

