
aposainin

acetovanillone anie kooda piluvabade aposinin, vanilinku nirmanatmakamga sambandhinchina sahaja sendriya sammelanam. idhi vividha rakaala mokkala vanarula nundi verucheyabadindi mariyu daani vividha aushadha lakshanaala kosam adhyayanam cheyabadutondi.
charitra.
aposainin nuu mottamodata 1883loe german aushadha shaastravetta oswald smeedeberg varninchaaru mariyu 1908loe kenadian janapanara ("aposinum canabinum") yokka muulam nundi horace finnemore dwara modata verucheyabadindi. aaa samayamlo, eee mokka ippatike vaapu mariyu gunde samasyalaku vyatiraekamgaa telisina prabhavam kosam upayoginchabadindi. 1971loe, paschima himalayala adhika ettulo perige "picroriza kurova" anae chinna mokka nundi kooda aposinin vaeru cheyabadindi. "pii. kaaleyam mariyu gunde samasyalu, kaamerlu mariyu ubbasam chikitsagaa kurrova "nuu yugaluga upayoginchaaru. 1990loe simens mariyu itarulu. kriyasilamga maarganirdesam cheyabadina isolation vidhananni upayoginchi aushadhashaastraparamgaa upayogakaramaina sthaayiki isolated aposainin. sareeramlo free radicals, oxygen ayanlu mariyu peroxidela erpaatunu empika cheyagala saamarthyam phalitamgaa aposinin yokka gamaninchina shotha nirodhaka saamarthyaalu niroopinchabaddaayi. aposinin daani vyaadhi-poraata saamarthyaalu mariyu anuvartanaalanu nirnayinchadamlo sahaayapadataaniki vistrutamgaa adhyayanam cheyabadindi.
bhouthika lakshanaalu.
aposinin anedi 115 masim draveebhavana sthaanam mariyu vanilla yokka masaka vaasana kaligina ghanapadaartham. idhi vaedi neeru, alkahal, benzene, chloroform mariyu eetharlalo karugutundi.
charya yokka vidhanam.
nadf accidase anedi oka enjaim, idhi samarthavantamgaa O2 nuu superoxide (O2-β) gaa taggistundi, dheenini roganirodhaka vyavastha bacteria mariyu sileendhraalanu champadaaniki upayoginchavacchu. aposinin anedi nadf accidase charyanu nirodhinchedi, anduvalla maanava tella rakta kanaalu ledhaa neutrophilic granulocytelalo superoxide utpattini nivaarinchadamlo prabhaavavantamgaa untundi. ayithe idhi granulocytela phagocytic ledhaa itara rakshana paatralaku aatamkam kaliginchadu. daani nirodhakata yokka empika kaaranamgaa, roganirodhaka vyavastha yokka itara amsaalalo jokyam chesukokunda nadaf accidase yokka nirodhakam vale aposininnu vistrutamgaa upayoginchavacchu.
moothrapindaala medullah kanaala pora antataa protan fluxes kaaranamgaa ionic kriyaaseelata superoxide yokka nadf oxidase utpattitoe jatacheyabadinda anie nirnayinchadaaniki aposinin upayoginchabadindi. aposinin kanaalaku parichayam cheyabadindi mariyu superoxide utpattini puurtigaa nirodhinchindi, mariyu nadf accidase kriyaaseelataku protan pravaham kaaranamani nirnayinchadamlo idhi oka keelaka bhaagam.
aposinin charya yokka vidhanam ardham kaaledu. prayogaatmaka adhyayanaalalo, aposainin dimerise chesi diaposynine nuu yerparustundani choopabadindi. reactive oxygen jaatulu mariyu shotha nirodhaka lakshanaalanu tagginchadamlo diaposynine prayojanakaramaina prabhavanni chuuputunnatlu kanipinchinappatikii, idhi inca jeevasaastraparamgaa sambandhita anuvugaa choopabadaledu. aposainin yokka jeeva parivartana pradhanamgaa aposainin yokka glycosylated roopaaniki daariteestundi. prayogaatmaka paristhitulalo erpade maroka anuvu nitroaposainin.
parisoedhana.
aposinin kosam chinna taraha prarambha dasha clinical trials 2011loe chronic obstructive pulmonary disease (sii. oo. pii. dii) mariyu 2012loe ubbasam kosam nirvahinchabaddaayi, conny avi marinta munduku saagaledu.
itara praathamika prii-clinical parisoedhanaloo ivi unnaih

