
prostin

prestin anedi ksheeradaalalo sunnitamaina vinikidiki keelakamaina protein. idhi "slc26a5" (draavakam vaahaka ayan ravana kutumbam 26, sabhyudu 5) janyuvu dwara encode cheyabadindi.
pristin anedi ksheerada koklia lopali chevi yokka bayati juttu kanaala yokka motaru protein. idhi bayati juttu kanaalalo ekkuvagaa vyakteekarinchabadutundi mariyu chalanaseelamaina lopali juttu kanaalalo vyakteekarinchabadadu. immunolocalisation anedi electromotility sambhavinche praantam, bayati juttu kanaala parshwa plasma poralo pristin vyakteekarinchabadutunda choopistundi. vyakteekarana namuunaa bayati juttu kana vidyudayaskaantata roopamtho sambandham kaligi untundi.
function.
shravana prakriyaloo pristin avasaram. idhi pratyaekamgaa koklia yokka bayati juttu kanaala (ohechsee) parshwa poralo vyakteekarinchabadutundi. puurtigaa abhivruddhi chendina ksheeradaalalo koklia yokka adhika-pounahpunyam mariyu takkuva-pounahpunyam praantaalalo pristin saandrata madhya gananeeyamaina vyatyaasam ledhu. ksheeradaalalo adhika pounahpunya vinikidi samuparjanatho sambandham unna ksheeradaalalo pristin anukuula parinaamaaniki guraindani manchi aadharalu unnaayi. prestin protein gabbilalu, timingalaalu mariyu dolphinlalo aneka samaantara amaino aamlam pratyaamnaayaalanu chooputundi, ivi swatantramgaa ultrasonic vinikidi mariyu ekolokeshannu abhivruddhi chesaayi, ivi kramam sthaayilo convergent parinaamam yokka arudaina kesulanu suuchistaayi.
pristin (mol. doubluty. 80 kda) anedi oka pratyaekamaina ayan ravana samstha, slc26loe sabhyudu. eee kutumbaaniki chendina sabhyulu nirmanatmakamga baga samrakshinchabaddaaru mariyu ksheerada kanaala plasma pora antataa chloride mariyu carbonate yokka electronutral maarpidiki madhyavartitvam cheyagalaru, bayati juttu kana kadalikaku avasaramaina rendu ayanlu. shaastreeya, enjaim aadhaarita motorla maadirigaa kakunda, eee kotta rakam motaru pratyaksha voltage-nundi-sthaanabhramsham marpidi meeda aadharapadi untundi mariyu itara cellular motaru proteinla kante vaegamgaa aneka parimaanaala kramaanni panichestundi. pristin yokka lakshya janyu antaraayam vyuuham shravana sunnitatvam yokka 100 retlu (ledhaa 40 db) nashtanni choopinchindi.
pristin anedi oka transmembrane protein, idhi yaantrikamgaa kudinchi, podavavutundi, idhi bayati juttu kanaala (ohechsi) vidyudayaskaantataku daariteestundi. vidyudayaskaantata anedi coclear amplifier yokka somatic motaru venuka unna chodaka shakti, idhi ksheerada parinaamam, idhi incoming sound wave frequencielaku sunnitatvaanni penchutundi mariyu tadwara signalnu vistaristundi. munupati parisoedhanalu eee modulation oka bahya voltage-sensor (pakshika ayan transporter modal) dwara jarugutundani suuchimchaayi, dheeni dwara chloride pristin yokka kanaantara vaipuku bandhinchi, panicheyani transporterloki pravesistundi, idhi pristin podavuku kaaranamavutundi. ayithe, pristin oka antargata voltage-sensor (IVs) dwara panichestundani kotta aadharalu unnaayi, dheenilo kanaantara chloride aakaraanni savarinchadaaniki pristintho alostericalga bandhistundi.
antargata voltage sensing.
antargata voltage-sensing yokka eee namoonaalo, ayanla kadalika naan leanier capacitance (nlc) nuu utpatti chestundi. utpatti cheyabadina voltage mariyu kanam yokka depolarised ledhaa hyperpolarised sthithi aadhaaramgaa, pristin rendu vibhina dasala dwara maarutundi, idhi pristin modulation yokka moodu-sthithi namuunaanu suuchistumdi. perugutunna vidhvamsam uddeepanalatoo, pristin podavaina sthithi nundi madhyantara sthithiki sankraminchi, daani nlcni penchutundani prayogaalu chuupistunnaayi. hyper polarising paristhitulalo, nlc taggutundi mariyu pristin daani podavaina sthithiki tirigi maarutundi. praamukhyata, pristin podugu dwara vargeekarinchabadina pora udriktata peragadam chloride kosam chloride alosteric binding sait anubandhaanni taggistundi, bahusha pristin modulation niyantranalo paatra poeshistumdi. podugu nundi sankuchita sthithiki modulationpy pristin yokka mottam anchanaa sthaanabhramsham 3-4 nm2. iteevali adhyayanam ivs namuunaaku maddatu istundi, idhi pristin yokka core membrane yokka intracellular vaipu vistarinchi unna 12 avasheshaala utparivartana phalitamgaa nlclo gananeeyamaina taggudala sambhavinchindani choopistundi. 12 avasheshaalalo enimidi sanukoolamgaa charge cheyabaddaayi mariyu pristin yokka allosteric chloride binding saitga tayaarayyaayani oohinchabadindi.
anayan ravana.
gatamlo laenatlu bhaavinchinappatikii, ventrukala kanaala vidyudayaskaantatanu nadipinche pristin saamardhyamlo anayan ravana kooda oka mukhyamaina amsamgaa choopabadindi. eee yantraangam utparivartana prayogaala aadhaaramgaa pristin yokka voltage-sensing saamarthyaala nundi swatantramgaa untundi, vividha utparivartanalu ayan-uptake ledhaa nlclo prabhaavaalaku daariteestaayani choopistundi, conny rendintiloo kaadu. chainees chitteluka andaasaya (choe) kanaalalo yekagratapai aadhaarapadina [14sii] formate up teknu choopinche parisoedhana aadhaaramgaa prestin oka antargata ayan-up take mechanismnu kaligi undani soochinchabadindi. eee phalitaalanu andakosalalo punarutpatti cheyalekapoyaru. anduvalla, andakosalalo ayan teesukoovadaaniki pristinku anubandha cofactor avasaram kaavacchu; ayithe, eee parikalpana ippatikee prasnaarthakam. vividha ayanlu mallet, chloride mariyu alchylsulphonic ayaanlatho sahaa pristin teesukoovadaaniki pootii padagalavani prayogaalu choopinchaayi.
aavishkarana.
2000loe peater dallos brundam pristiinnu kanugoni, protein vegam kaaranamgaa sangeeta sanketam pristo nundi paeru pettindi.
2003loe daani aavishkartalu prestin anuvuku patent pondaaru.
clinical praamukhyata.
slc26eah5 janyuvulo utparivartanalu syndromic kaani vinikidi lopamtho mudipadi unnaayi.
blockers.
ksheeradaala pristin yokka electromotyl paniteeru millimolar saandratala vadda amphiphilic anayan solicilate dwara nirodhinchabadutundi. solicilate yokka application motaadu-aadhaarita mariyu takshaname tirigi marchagala paddhatiloo pristin paniteerunu nirodhistundi.