
prii-metastatic samuchitam

prii-metastatic samuchitam anedi dviteeya avayavamlo oka vaataavaranam, idhi praathamika kaniti yokka metastassisku anukuulamgaa untundi. atuvanti samuchita sthaanam praathamika kaniti kanaalaku videshee mariyu pratikuula vaataavaranamloo perugudalaku anukuulamaina paristhitulanu andistundi, mariyu chivariki metastassisnu andistundi. eee bhavana kaniti perugudala mariyu metastassisnu niyantrinchadamlo suukshma paryaavaranam yokka praathamika paatranu pradarsinchindi. prii-metastatic samuchitam yokka aavishkarana, myeloid nundi utpannamaina nirodhaka kanaalanu lakshyamgaa chesukovadam, mariyu fibroblastlu mariyu perisaitlu mariyu perivascular mruduvaina kandara kanaalatoe sahaa stromal sell plasticity mariyu (praadhamika kanitula nundi dviteeya avayavaalalo prii-metastatic samuchitaalaku mariyu suukshma paryaavarana lakshya chikitsala yokka vividha kalayikalaku vesicles pravahanni aapadaniki prayatnaalu cheyadam vanti metastagela sambhaavya chikitsaku sambandhinchi kotta parisoedhananu prothsahinchindi.
prii-metastatic samuchita nirmaanam.
vaidyaparamgaa sambandhita metastasis erpadataaniki mundu eee pratyeka pradaesaalaku wezfr1 (vascular endothelial groth phyaaktar receptor 1) mariyu stromal kanaalanu vyaktam chese hematopoietic emuka majja kanaala valasala kaaranamgaa kanitulu nirdishta avayavalaku metastasize avtayi. eee kanaalu extracellular matrickslo maarpulatoe paatu prii-metastatic goollanu yerparustaayi, ivi vyaapti chendina kaniti kanaalaku maddatu istayi mariyu eee kanaalu sekarinchadaaniki mariyu avayavam marinta sulabhamgaa valasarajyaluga maaradaaniki veelu kalpistaayi. roganirodhaka vyavasthanu anachiveyadam mariyu saitokinlu mariyu itara perugudala kaarakaala uniki perugudalato sahaa aneka vibhina saareeraka prakriyala dwara prii-metastatic samuchita nirmaanam prabhaavitamavutundi. mariyu extra cellular matricks nikshepana mariyu punarnirmaanam 
praadhamika kanitilo hypoxia mariyu praadhamika kaniti nundi dviteeya avayavaniki exosomla kadalika anedi prii-metastatic goollu erpadataaniki paakshikamgaa baadhyata vahinche adanapu drugvishayaalu.
metastasislo paatra.
metastasize cheyadaaniki, kaniti kanaalu vaati perugudalaku anukuulamaina vaataavaranam unna oka avayavaniki cherukovali, prii-metastatic samuchitam vantivi. eee vaataavaranaanni srushtinchadam anedi praadhamika kaniti nundi kanaalu marinta sulabhamgaa dviteeya avayavanni valasarajyaluga maarchadaaniki veelugaa dviteeya avayavam yokka nirmaanaanni marche praadhamika kaniti nundi karakalu dwara saadhinchabadutundi. kaniti kanaalu emuka kanaalu tirigi grahinchadaaniki kaaranamayye kaarakaalanu vidudala chestaayi, anduvalla metastasis retunu penchutaayi. emuka aneka rakaala kanaala kuurpu mariyu asthipanjara nirmaanaalanu penche saamarthyaanni batti metastatic prakriyaku anukuulamgaa untundi. prii-metastatic samuchita nirmaanam prakriya lekunda, metastases sambhavinche avakaasam takkuvagaa untundi. metastasis laeni avayavaalalo tarachugaa kaniti kana niksheepaalu kanipistaayi, idhi prasarana vyavasthanu vidichipettina tarvaata avi pravesinche kanajaalaalo metastases ellappuduu vistarinchavani suuchistumdi.
roganirodhaka vyavastha yokka paatra.
churukaina roganirodhaka saktini anachiveyadam valla prii-metastatic samuchita nirmaanam saadhyamavutundi. praadhamika kanitulu myeloid utpannamaina nirodhaka kanaalanu niyamistaayi, ivi antigen pradarsananu nirodhinchagala myeloid kanaalu mariyu tii kanaalu madhyavartitva cytotoxicity, kaniti kanaalu roganirodhaka vyavastha dwara gurtinchabadakunda undataaniki veelugaa avi metastasize avtayi, tadwara metastasis vruddhi chendadaaniki veelu kalpistundi. praadhamika kanitulu raktapravaahamloki kaniti kanaalanu vidudala chestaayi kabatti, kaniti dwara niyaminchabadina myeloid kanaalu, cancer kanaalanu anukuula roganirodhaka vyavastha dwara gurtinchakundaa rakshinchagalavu, lekapothe ivi metastassisnu aaputaayi. kanaala abhivruddhilo vividha dasalalo niyaminchabadina myeloid progenitor kanaalu, kaniti kanaalanu praamaanika roganirodhaka pratispandana nundi rakshinchagalavu, endukante avi kaniti kanaalanu puurva-metastatic samuchita sthaanaanni valasarajyamga maarchadaaniki prayatnistaayi. roganirodhaka vyavastha daadula nundi perugutunna metastassisnu rakshinchadamlo matrame kakunda, extravasation praarambhinchadamlo kooda vaati mukhyamaina paatranu batti, prii-metastatic samuchitam abhivruddhilo myeloid kanaalu keelaka karakamga untaayi, tadwara chivariki metastasesnu prothsahistaayi.
sanketha anuvula taragati ayina chemokinlu kooda prii-metastatic goollu mariyu metastasela srushtilo mukhyamaina paatra poeshistaayi. praadhamika kaniti, roganirodhaka vyavastha dwara gurtinchakundaa undataaniki, emuka majja nundi utpannamaina myeloid kanaalanu dviteeya avayavalaku niyaminchadaanni penchadaaniki chemokinlanu upayogistundi. adanamgaa, praadhamika kaniti nundi cancer kanaalanu dviteeya avayavamloni prii-metastatic samuchitam yokka bhavishyat pradaesamloe vaapunu prerepinchadaaniki upayoginchavacchu, idhi sankramana dwara srushtinchabadina roganirodhaka pratispandananu pooli untundi.
anduvalla, roganirodhaka kanaala pedda uniki roganirodhaka vyavastha daadulanu nivaarinchadaaniki prii-metastatic samuchita sthaanaanni anumatistundi, anduvalla kaniti nirodham lekunda metastasize cheyadaaniki anumatistundi. roganirodhaka vyavastha yokka vilakshana pratispandana dwara naasanam kakunda kaniti kanaalu videshee mariyu pratikuula vaataavaranamloo peragadaaniki veelu kalpistaayi kabatti, itara prakriyalatho paatu, hypoxia mariyu ecm thoo kalipi roganirodhaka anachiveta, praadhamika kanitini metastasize cheyadaaniki anumatinchadamlo avasaramaina dasalu. pratyaekamgaa, avasaramaina amaino aamlalu ksheenistaayi mariyu lymphocyte kadalika taggutundi, ayithe roganirodhaka vyavasthanu anichivese niyantrana tii kanaalu mariyu aakseekarana ottidi perugutaayi.
prii-metastatic samuchitam yokka aavishkarana.
metastasis saadhaaranamgaa konni saadhaarana dasalugaa ghaneebhavinchabadindi, avi kaniti kanaalu praadhamika kanitini vadili, prasarana vyavastha dwara dviteeya avayavalaku prayaaninchi, prii-metastatic avayavam yokka videshee vaataavaranampai daadi chese prayatnamlo untaayi. kotta mariyu saapekshamgaa pratikuula vaataavaranamloo kaniti perugudala tarachugaa kashtamgaa untundi kabatti, adhika maranaala raetu unnappatikee, metastassisnu chaalaa mandhi asamarthamaina prakriyagaa bhaavinchaaru. stephen paget yokka gatamlo sthaapinchabadina 'vittana mariyu matti' parikalpana praadhamika kaniti kanaalu prii-metastatic goollaku valasa vellae kotta aalochanatho sambandham kaligi unnappatikee, chaalaa mandhi parisoedhakula drushti praathamika kaniti nundi maarutondi, kaniti samakshamlo metastasis yokka anivaaryatanu oohinchinanduna, metastases sambhavinche dviteeya avayavalaku. metastasis kosam praathamika avayavaalalo exosomla paatra iteevala parisoedhakulaloo charchaneeyaamsamgaa maarindi, endukante metastases laeni avayavaalalo kaniti kanaala nikshaepaalanu kanugonadam valla. prii-metastatic samuchitam yokka bhavananu david lyden prayogasaalalo doctors kanugonnaru. david lyden mariyu stergios jacharaulis, mariyu prii-metastatic samuchitam modata vivarinchabadindi mariyu doctors dwara vargeekarinchabadindi. rosandra cuplan, rebecca riba, stergios jacharaulis mariyu itarulu., 2005loe.
cancer chikitsapai prabhavam.
prii-metastatic samuchitam anae bhavananu gurtinchadam valla parisoedhakulu cancer chikitsaku aneka kotta avakaasaalanu pariseelinchadaaniki veelu kalpistundi. atuvanti oka avakaasam emitante, kanaalalo wezfr1 yokka vyakteekarananu parimitam cheyadaaniki prayatninche paddhatulanu upayoginchadam, tadwara metastassisnu edurkovadam dwara prii-metastatic samuchitam yokka srushtini alasyam cheyadam ledhaa puurtigaa nirmoolinchadam dwara. praadhamika kanitilo hypoxianu lakshyamgaa chesukovadam mariyu roganirodhaka vyavasthanu anachiveyadam kooda prii-metastatic goolla srushtini aapavacchu. kaniti kanaala dwara daani valasarajyanni sulabhataram cheyadaaniki dviteeya avayavanni nirmanatmakamga marche praadhamika kaniti nundi karakalu kooda metastassisnu aapadaniki chese prayatnamlo lakshyamgaa undavacchu.
vividha suukshma vaataavaranaalaloo perige kaniti kanaalu vividha rakaala proteinlanu andistaayi, idhi vibhina pradaesaalaloo kanitulaku vividha rakaala oncological chikitsalu avasaramani suuchistumdi. metastasis yokka taruvaati dasalanu lakshyamgaa chesukovadam sulabham endukante metastasis yokka prarambha dasalu poortayye varaku cancer tarachugaa kanugonabadadu. anduvalla, metastassisnu edurkone praathamika chikitsalu mariyu aushadhaala kalayikanu kaniti kanaala dwara dviteeya avayavam yokka valasarajyalanu nirodhinchadaaniki upayoginchavacchu, endukante idhi kaniti nundi pravahinche kanaalu mariyu prii-metastatic samuchitam erpadataanni aaputundi. pratyamnaayamgaa, kaniti kanaalu prii-metastatic goollaku valasapokunda aapadaniki mandulanu upayoginchadam anedi metastagelanu aapadaniki samarthavanthamaina paddhati kaavacchu.

