
carbetosin

itara brandla paerlatoe paatu pabal paerutoe vikrayinche carbetosin, prasava tarvaata, mukhyamgaa sijerian vibhagam taruvaata adhika raktasraavam nivaarinchadaaniki upayoginche aushadham. idhi oxytosine thoo paatu panichestundani telustondi. itara empikala kante idhi takkuva podupugaa unnanduna, enhetchs scatland dheenini upayoginchamani sifaarasu cheyaledu. idhi sira ledhaa kandaraalaloki injection dwara ivvabadutundi.
chikitsa ledhaa placebo laeni dushprabhaavaala kante dushprabhaavaalu chaalaa takkuvagaa untaayi. muurcha ledhaa eclampsia unnavaarilo upayogam sifaarsu cheyabadadu. carbetosin anedi oxytosine yokka sudeerghamaina paniteeru roopamgaa tayaaru cheyabadutundi. idhi garbhasayam kudinchadaaniki kaaranamayye oxytosine grahakanni sakriyam cheyadam dwara panichestundi.
carbetosin mottamodata 1974loe varninchabadindi. idhi 1997loe kenada mariyu united kingdamlo vaidya upayogam kosam aamodinchabadindi. idhi prapancha aarogya samstha yokka avasaramaina aushadhaala jaabitaalo undhi. idhi united states ledhaa japaanlo andubaatulo ledhu.
vaidya upayogaalu.
sthaanika ledhaa vennemuka anaesthesia upayoginchinappudu elective sijerian vibhagam taruvaata ventane upayoginchadaaniki carbetosin aamodinchabadindi. sijerian vibhaagamlo kotha tarvaata garbhasayam daani swantadaanipai kudinchaleni kaaranamgaa, garbhasaya tone punaruddharinchadaaniki mariyu raktasraavaanni nivaarinchadaaniki oxytosine ledhaa analog yokka bahya paripalana avasaram.
yoni jananaalu mariyu atyavasara sijerian vibhagala taruvaata carbetosin yokka bhadrata sthaapinchabadaledu, ayinappatikee adhyayanalu yoni jananaala taruvaata tadupari sijerian vibhaagaalaku samarthatanu suuchimchaayi. yoni delivery tarvaata 10-70 ug motaadu sankochaaniki kaaranamai, etuvanti pratikuula dushprabhaavaalu levani konni adhyayanalu choopinchaayi. carbetosin maanavulu, gurralu mariyu aavulalo garbhasaya involution (sisuvu puttina tarvaata garbhasayam daani kudinchina sthithiki tirigi ravadam) nuu kooda penchutundani choopabadindi.
itara mandulatho polchandi.
2018loe, kathinamaina sheetaleekarana avasaram laeni ushna-sthiramaina carbetosin, yoni delivery tarvaata prasavaanantara raktasraavam tagginchadaaniki oxytosine vale manchidani kanugonabadindi. idhi oxytosic raktasraavam niyantrananu marinta vistrutamgaa andubaatulo mariyu takkuva kharchutho kuudukunnadigaa chestundani bhaavistunnaaru, idhi vidyut antaraayaalu ledhaa parikaraala samasyala kaaranamgaa colled chain (aushadha ravana mariyu nilvalo) nammadagani abhivruddhi chendutunna deshaala praantaalalo mukhyamgaa upayogapadutundi.
carbetosin yokka gananeeyamgaa ekkuva ardha-jeevitam kaaranamgaa, daani prabhavalu oxytosine ledhaa barusiban vanti itara oxytosine homologla kante ekkuva kaalam untaayi. yaadruchchika andha adhyayanamlo placebo ledhaa enimidi gantala intravenous drip off oxytosine thoo poliste oke carbetosin motaadu, sijerian vibhagam taruvaata takkuva adanapu oxytosine chikitsa avasaramaindi. barusiban ledhaa autosiban vanti oxytosine grahaka vyatiraekulu, oxytosine grahaka karyakalapalanu nirutsaahapariche vyatiraeka prabhavanni kaligi untaayi mariyu akaala prasavam mariyu garbhasaya sankochaalanu aapadaniki upayoginchavacchu.
pratikuula prabhavalu.
padhi nundi nalabhai saatam mandhi prajalu vikaram, vaantulu, kadupu noppi, charmam durada, shareera ushnograta peragadam, vanuku mariyu balaheenatanu anubhavistaaru. okati nundi aidu saatam mandhi prajalu vennunoppi mariyu chaatii noppi, maikamu, raktaheenata, chali mariyu chemata, lohapu ruchi, tachycardia mariyu swaasakosha badhanu anubhavinchavacchu.
carbetosin vaadakaaniki vyatirekatallo prasava samayamlo mariyu prasava samayamlo (prasavaniki mundu ledhaa prasavaanni prerepinchadam vantivi) ledhaa carbetosin ledhaa itara oxytosine homolaglaku allergy praticharyalu anuchitamaina samayam. adanamgaa, oka vyaktiki adhika raktapotu ledhaa hridaya sambandha samasyalu unte carbetosin vaadakuudadu. carbetosin yokka adhika motaadu ledhaa padepade upayogam, mukhyamgaa garbhadhaarana samayamlo upayoginchinatlayithe, oxytosine graahakaala adhika-utsaaham kaligistundi, phalitamgaa garbhasaya sankochaalu adhika mariyu deerghakaalika uddeepanaku daariteestundi, garbhasaya cheelika, placental antaraayam, pindam swaasakosha baadha mariyu prasavaanantara raktasraavam pramaadaanni penchutundi.
paraspara charyalu.
vasopressinto oxytosine yokka close sequence homology kaaranamgaa, oxytosine analogues tarachugaa garbhasaya lininglo vasopressin grahakaalu v1 mariyu moothrapindaallo v2 thoo chaalaa takkuva anubandhaanni kaligi untaayi mariyu tatphalitamgaa vasopressin circutory mariyu feedback looplatho sankarshana chendavacchu ledhaa antaraayam kaliginchavacchu. garbhaasayaanni pandinche dynoprostone mariyu misoprostole vanti mandulatho carbetosin synergisticga panicheyavacchu. eee aushadhaalanu ekakaalamlo upayoginchadam pramaadakaram, mukhyamgaa garbham mariyu prasavapurva samrakshana samayamlo, bahusha akaala prasava ledhaa garbhasraavaaniki kaaranamavutundi.
aushadha shaastram.
charya yokka yantraangam.
carbetosin paridheeya naadii vyavasthalo oxytosic, antihemorogic mariyu garbhasaya aushadhamgaa panichestundi. prasavaanantara raktasraavam yokka atyanta saadhaarana kaaranaalu garbhaasayamlo atigaa saagadeeyadam ledhaa mattumandu vadakam valla tone lekapovadam.
carbetosin paridheeya oxytosine graahakaala vadda, mukhyamgaa myometriumlo, myopithelial kanaalaku takkuva anubandhaanni kaligi, agonistga panichestundi. oxytosine grahakaalu zii protein-kapul cheyabadataayi mariyu vaati charya yokka yantraamgamlo rendava sandesavaahakulu mariyu innocital phosphatel utpatti untaayi. carbetosin eee yantraamgaanni anukaristundi. carbetosin mariyu itara oxytosine agonistulaku binding anedi extra cellular enn-terminus mariyu loops e2 mariyu e3 vadda naan selectivga choopabadindi. oxytosine receptor oxytosine mariyu carbetosinlaku samaana anubandhaanni chooputundi, carbetosin yokka jeeva prabhavam endogenous ledhaa exogenous oxytosine kante daadaapu 50 saatam untundi. oxytosine kante carbetosin chaalaa ekkuva kaalam konasage prabhavanni kaligi untundi, dheeniki oke motaadu matrame avasaram. carbetosin antarjanita oxytosine vidudalanu nirodhistundi, hypothalamastho garbhasaya pratispandana loopku antaraayam kaligistundi mariyu oxytosine yokka kendra mariyu paridheeya vidudalanu taggistundi. carbetosin anedi oxytosine grahakam yokka pakshapaata agonist.
garbhadhaarana samayamlo, garbhaasayamlo oxytosine graahakaala samslaeshanha baga perugutundi, prasava mariyu prasava samayamlo garishta sthaayiki cherukuntundi. tatphalitamgaa, puttina samayamlo ledhaa ventane carbetosin ledhaa maroka oxytosine analog ivvadam valla garbhasaya mariyu sankocham prabhavam perugutundi. carbetosin yokka anuvartanam takkuva oxytosine grahaka vyakteekaranhatho garbhavati kaani garbhaasayamnu prabhaavitam cheyadu. carbetosin raktam mandamgaa undataaniki kooda panichestundi, prasavaanantara raktasraavamnu marinta nirodhistundi. talli ledhaa sisuvuku gunde ledhaa swaasakosha badhanu kaliginchavacchu kabatti prasavaanni prerepinchadaaniki ledhaa penchadaaniki carbetosinnu upayoginchakudadu.
pharmacokinetics.
aasupatrilo prescription dwara matrame carbetosin upayoginchaali. dheenini intraveenasga ledhaa intramuscular gaa ivvavacchu. rendu sandarbhaallo, sagatu vayojana mahilaku sifaarsu cheyabadina motaadu 100 yuji. garbhasayam yokka sankocham prabhavalu rendu nimishaallo spashtamgaa kanipistaayi mariyu sumaru oka ganta paatu gamaninchavacchu, ayithe intramuscular injection tarvaata garishta bandham 30 nimishalu sambhavistundi. garbhasaya sankochaalanu prerepinchadam, kandaraala tone penchadam mariyu raktaanni gattipadatam dwara prasavaanantara raktasraavam pramaadaanni tagginchadaaniki prasavaanantaram ventane paripalana nirvahinchabadutundi. garbhaasayamlo marinta uddeepana avasaramaite, itara rakaala oxytosic garbhasaya mandulatho chikitsanu upayoginchaali.
antarjanyu mariyu synthetic oxytosine sumaru 3.5minutes sagam jeevitakaalam kaligi untundi. carbetosin, polchi choosthe, 85 nundi 100 nimishala varaku chaalaa ekkuva ardha-jeevitaanni kaligi untundi. jeeva labhyata motaadu daadaapu 80 saatam untundi. intravenous administration taruvaata elemination sagam jeevitam sumaru 40 nimishalu, ayithe elemination mechanism puurtigaa teliyadu. tolagimpu anedi moothrapindaala (0.7%) loe athi takkuva matrame anie adhyayanalu choopinchaayi, conny peptides yokka enzymatic ksheenata dwara kaneesam paakshikamgaa sambhavinchavachhu, pradhanamgaa sii-terminal chivaralo. tolagimpu mariyu pampinhee parimaanam rendoo motaadu meeda aadharapadi undavu.
samajam mariyu samskruti.
chattaparamaina aamodam.
united statesto sahaa 23 deshaalalo eee krindi moodu brand paerlatoe upayoginchadaaniki carbetosin aamodinchabadindih duratosine (argentine, australia, bahrain, kenada, chaina, hankong, italii, malaysia, singapur, newzealand), lonactin (mexico), mariyu pabal (austria, belgium, switzerland, germany, estonia, france, yuke, hangari, lithuvania, luxemben, finland). polland, germany, italii, belgium, luxemberg, france mariyu netherlandslo pasuvaidya upayogam kosam kooda duratosine aamodinchabadindi.
brand paerlu.
duratosine, pabal, lonactin, deposine, comoton mariyu decomoton.