
gaboxadol

gaboxadol, dheenini 4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridine-3-oll (thip) anie kooda pilustaaru, idhi alcoloid muskimol yokka conformationalga parimitam cheyabadina utpannam, dheenini 1977loe danish rasayana shaastravetta poval crogsgard-larsen modatisaari samslaeshanha chesaaru. 1980la praarambhamlo gaboxadol anedi analgesic mariyu angioliticga daani saamarthyaanni pareekshinchina varusa prayogaatmaka adhyayanalaku sambandhinchina amsamgaa undhi, alaage tardive diaskinisia, huntington vyaadhi, algimers vyaadhi mariyu spaastisitiiki chikitsagaa undhi. nidralemi chikitsa kosam gaboxadol yokka tarachugaa nivedinchabadina upasamanakaari "pratikuula prabhavam" nuu upayoginchadaaniki parisoedhakulu 1996 varaku prayatninchaledu, phalitamgaa lundbeck mariyu merk spaansar chesina clinical trials varusaku daariteesindi. marchi, 2007loe, merk mariyu lundbeck bhadrata aandolanalu mariyu samarthatha pareeksha vaiphalyaanni paerkontuu aushadhampai panini raddu chesaaru. idhi gaba vyavasthapai panichestundi, conny benzodiazipines, jedd-drugs mariyu barbituratela nundi bhinnamaina reetilo panichestundi. gaboxadol kooda gaadha nidranu penchutundani (dasha 4) lundbeck paerkonnaadu. benzodiazipines maadirigaa kakunda, ventral tegmental praantamloo dopaminergic neuronlu kriyaaseelakam ayinappatikee thip elukalu ledhaa baboonlalo upabalaanni pradarsinchadu.
2015loe, lundbeck anuvupai thana hakkulanu ovid therapeuticsku vikrayinchindi, dheenini efxs mariyu angelman syndrome kosam abhivruddhi cheyalane pranaalika undhi. idhi andakaramlo antargatamgaa oo. vii. 101 gaa piluvabadutundi.

