
fam163yea

sebelin mariyu neuroblastoma-utpanna sraava protein (enn. dii. ess. pii) anie kooda piluvabade eff. eah. emm. 163eah anedi maanavulalo eff. eah. emm. 163eah janyuvu dwara encode cheyabadina protein. eee protein neuroblastoma cancer kanaala vistarana mariyu langaru-swatantra perugudalanu prothsahinchadamlo chikkukundi. adanamgaa, eee protein deerghakaalika dhumapanam chese vaari oopiritittula kanajaalamlo niyantrinchabadutundani kanugonabadindi. "fam163a" maanava chromosome 1q25.2 loe kanipistundi; daani protein utpatti 167 amaino aamlaala podavu untundi. fam163yea chaalaa ekkuvagaa samrakshinchabadina signal peptide kramaanni kaligi undhi, daani kramamlo modati ~ 37 amaino aamlaala dwara code cheyabadindi; eucariotslo matrame samrakshinchabadinappatiki, veetilo atyanta dhooramlo unna japanese vari chepalu.
janyuvu.
"fam163a" sumaru 2,927 bays jatala podavu, aidu exanlanu kaligi untundi. teliyani function yokka domainlu aevee namodu cheyabadanappatiki, janyuvu yokka coding praantam chaalaa chinnadi (~ 500 bays jatala), anoohyamgaa podavainadi mariyu inca vargeekarinchani 3 'anuvaadam cheyani praantam (utr). "fam163a" "chromosome 1 yokka saanukuula tantuvupai, loki126860loe, moodu itara janyuvulaku sameepamlo undih" "taar1aipi1", "" "taar1aipi2", "mariyu" "tdrd5".
mrna.
45 neuroblastoma kaniti namoonaalalo mrna sthaayilu pareekshinchabaddaayi; veetilo 43 namoonaalalo, endespi yokka adhika sthaayilu kanugonabaddayi, alaage aidu emuka majja namoonaalalo kanugonabaddayi. emuka majja mariyu naadii kanajaalamlo cancer metastasis abhivruddhi chendhe pramaadaanni penchadamtho enn. dii. ess. pii. mudipadi untundi. enn. dii. ess. pii. kii vyatiraekamgaa upayoginchina aarr. enn. yea. nirodha paddhatulu cellular vistarana mariyu cancer sell kaalanee erpadataanni tagginchaayi. inca, eee protein erk-madhyavartitva maargam dwara vruddhi karakamga panicheyaalani nirnayinchaaru.
splies vaeriyantlu.
fam163a" mrna yokka saadhyamayye splies vaeriyantlanu roopondinchadaaniki aneka prograamlanu upayoginchavacchu. eee samuuha database oka saadhyamayye splies roopaantaraanni istundi, idhi fam163yea protein kosam code cheyabadindi. enn. sii. bii. ii yokka aes view 23 saadhyamaina splies vaividhyaalanu andistundi, conny veetitho etuvanti prayogaatmaka aadharalu sambandham kaligi laevu.
protein.
maanava protein 17.6 kilodaltonla (kedi) paramaanu baruvunu kaligi untundi mariyu 5.56 isoelectric point kaligi untundi. orthologllo polchinappudu, eee viluvalu baga samrakshinchabadataayi. chivaraga, expassy programme psortii nucleuselo protein sthaanikeekaranaku 39.1% avakaasaanni anchanaa vestundi; idhi yea pradaesaanikainaa atyadhika sambhaavyata.
homology.
eee krindi dayta enn. sii. bii. ii. paeludu prograamnu upayoginchi roopondinchabadindi. eee srenulannintilo oka aasaktikaramaina muulaamsam signal peptide kramam yokka asaadhaaranamaina parirakshana; vasudevan, mariyu itarulu.'maanavulalo samaantara protein (fam163bii) mariyu elukalalo fam163eah ortholognu polchina bioinformatic vislaeshanha eee adhyayanaalalo unnaayi. vaati phalitaalu krinda samarpinchina orthologla vislaeshanhatoe samalekhanam cheyabaddaayi; jabita cheyani jaatulalo fam163yea kosam aneka, aneka orthologlu unnappatikee, japanese vari chepalu signal peptide kramaanni panchukune chivari orthologus jaatulu, tadupari sameepa phalitam 30 saatam kante takkuva saatam gurtimpunu kaligi untundi mariyu parirakshana yokka sambhaavya domainlu laevu.
paralogs.
fam163eki oke oka peralogue undih fam163bii, chromosome 9q34.2 paie undhi. rendu proteinla madhya poolika signal peptide kramam okela undani velladistundi; sdsc yokka biology workbench dwara clustalve prograamnu upayoginchi, kramaala gurtimpunu drushyamaanam cheyadam saadhyamaindi.
kanajaala pampinhee.
sariiramlooni chaalaa kanajaalaalo chaalaa takkuva sthaayilalo fam163yea sarvavyaaptamgaa vyakteekarinchabadutundi; baalyamlo vyakteekarana ekkuvagaa untundi, mariyu gatamlo chuusinatlugaa, deerghakaalika dhumapanam chesevari oopiritittulu mariyu neuroblastoma kanaalalo.

