
ess 100 protein

ess 100 proteins sakasherukaalalo kanipinche takkuva paramaanu-baruvu proteinla kutumbam, ivi helix-loop-helix ("ef-hanned-type") conformation kaligina rendu calcium-binding saitlatho vargeekarinchabaddaayi. kaneesam 21 ververu ess 100 proteins telisinavi. avi janyuvula kutumbam dwara encode cheyabadataayi, vaati chihnalu "s100" upasarganu upayogistaayi, udaaharanaku, "s100a1", "s100a2", "s100a3".
avi nashtam-sambandhita paramaanu namuunaa anuvulugaa (damps) kooda pariganinchabadataayi, mariyu aaril hydrocarbon grahakam yokka nock down thp-1 kanaalalo s100 proteinla vyakteekarananu taggistundi.
nirmaanam.
chaalaa varaku ess100 proteins rendu saaruupya polypeptides (homodymeric) nuu kaligi untaayi, ivi naan-covalent bandhaala dwara kalisi untaayi. avi nirmaanaparamgaa kaalamodulin nuu pooli untaayi. ayithe, itara lakshanaalalo avi kaalamodulin nundi bhinnamgaa untaayi. udaaharanaku, vaati vyakteekarana namuunaa kana-nirdishtamainadi, i.ii. avi pratyeka kana rakaalalo vyakteekarinchabadataayi. vaati vyakteekarana paryaavarana karakalapai aadharapadi untundi. dheeniki viruddhamgaa, kaalamodulin anedi sarvavyaapta mariyu saarvatrika kanaantara CA2 + grahakam, idhi aneka kanaalalo vistrutamgaa vyakteekarinchabadutundi.
saadhaarana paniteeru.
S100 proteins saadhaaranamgaa neural crest (shwan kanaalu mariyu melanocytelu), kondrosaitlu, adiposaitlu, myopithelial kanaalu, macrophaselu, langerhans kanaalu, dendritic kanaalu mariyu caratinocytela nundi utpannamayye kanaalalo untaayi. avi konni rommu epithelial kanaalalo undavacchu.
protein phosphorylation, transcription karakalu, Ca2 + homeostasis, cytoskeleton bhagala dynamics, enjaim karyakalapalu, kana perugudala mariyu bhedam mariyu inflammatory pratispandana vanti vividha rakaala intracellular mariyu extracellular vidhullo s100 proteins chikkukunnayi. S100a7 (psoriasin) mariyu S100a15 vaapulo, mukhyamgaa psoriasis vanti swayam pratirakshaka charma paristhitulalo cytokinluga panicheestaayani kanugonabadindi.
pathology.
S100 protein kutumbaaniki chendina aneka mandhi sabhyulu konni kanitulu mariyu epidermal bhedaaniki gurtulugaa upayogapadataru. ivi melanomas, shwanomas yokka 100%, neurofibromas yokka 100% (shwanomas kante balaheenamainavi), praanaantaka paridheeya naraala kavacham kanitulalo 50 saatam (balaheenamaina mariyu/ledhaa phokal kaavacchu), paraganglioma stromal kanaalu, hystiocytoma mariyu clear-sell sarcomalalo kanipistaayi. inca, ess 100 proteins inflammatory vyaadhulaku markerlu mariyu vaapuku madhyavartitvam vahinchagalavu mariyu antimicrobialsga panicheestaayi. shareera nirmaana shaastram kosam kana gurtulugaa prayogasaalalo ess 100 proteins upayoginchabaddaayi.
naamakaranam.
s100" chihna upasarga eee proteins 100%, i loe karugutayani suuchistumdi.ii. tatastha pH vadda santrupta, ammonium sulfate. eee chihnam tarachugaa hyphenate cheyabadindi, conny hugo janyu naamakarana kamitee naamakaranamu vanti prastuta janyuvu mariyu protein naamakaranamu, chihnalalo hyphenlanu upayoginchavu.

