
jeey. eff. 3

junctophiline-3 heey manavanmadhil eka prathine aahe jeey "jeey. eff. 3" janukadware encode kelele aahe. januk andaje 97 kilobes lamb aahe aanee 16q24.2 sthiteet sthit aahe. junctophiline prathine heey uttejak peshinmadhil endoplasmic reticulumshi plazma membrainla jodana junctional membrain complexchya nirmitishi sambandhit aahet. junctophiline-3 heey mendusathi vishisht aahe aanee motor samanvay aanee smrutimadhye guntalelya neuronsmadhye tyachi sakriy bhoomika aahe.
prathinanmadhye 748 amino acid avashesh asatat aanee teey endoplasmic/sarcoplasmic reticulum patalavar pasarlelya see-terminal hydrophobic vibhagane banalele asate aanee urvarit cytoplasmic kshetra jeey plazma patalasathi vishisht aakarshan darshavate. prathinanmadhye anek sakalchya (puttle adhibhog aanee olakh jode) punaravrutti asatat jyaa phospholipidschya parasparsanvadvare plazma puttle bandhanimadhye yogdan detat.
junctophiline-3 pramukhyane mendumadhye, visheshtah dorsolateral prefrontal cortexmadhye vyakt kele jaate. prathinanche achook karya jaree nishchit kele gele nasale taree karyaksham calcium aayan signalling aanee neuronal cellular architecturechya sthirikaranadvare motor samanvay aanee smrutimadhye bhoomika bajavanyache teey darshavile gele aahe.
jeey. eff. 3 janukamadhye cag/see. tii. jee. trinucleotide punaravrutti vibhag asato. yaa bhagacha vistar anek polyglutamine roganshi (polycue) sambandhit aahe, jyat spinocerabler attaxia, huntington rog aanee huntington rog-2 (etch. dii. ell. 2) yancha samavesh aahe. cag repeat coding kshetrachya pathological vistaramule vistarit polyck marg tayar hoto, joou degenerated neuronsmadhye ektrit hoto jyamule vishisht neuronal up-loksankhyeche adhahpatan hote.