
pii. ell. keey. 4

serine/threonin-prathine keynage pii. ell. keey. 4, jyala pooloo-sarkhya keynage 4 mhanoonahi olakhale jaate, heey eka enzyme aahe jeey manavanmadhye "pii. ell. keey. 4" janukadware encode kele jaate. drosophila homolog haah suck aahe, see elegans homolog haah zayag-1 aahe aanee zenopus homolog haah pii. ell. ex. 4 aahe.
karya.
"pii. ell. keey. 4". serine/threonine prathinanchya kaynesesachya pooloo kutumbatil sadasyala sanketikrut karate. prathine centriolsmadhye sthanbaddh hotat-centrosomesmadhe aadhalanaya jatil microtubule-aadharit sanrachana-aanee peshi chakradarmyan centriol duplication niyantrit karatat. pii. ell. keey. 4 chya atiprabhavamule centrosome pravardhan hote aanee pii. ell. keey. 4 chya khalee padalyane centrosome nasht hotat.
rachana.
pii. ell. keey. 4 madhye aine-terminal kinez domain (avashesh 12-284) aanee see-terminal sthanikikaran domain (avashesh 596-898) aahe. polosarkhya itar keynage sadasyanmadhye 2 see-terminal pooloo boxes domain (pii. bii. dii.) asatat. pii. ell. keey. 4 madhye tisya pii. bii. dii. vyatirikt hii 2 kshetre aahet, jee oligomerization, lakshyikaran sulabh karate aanee trans-autophosphorylationla protsahan dete, centriol duplicationla prati peshi chakr ekada maryadit karate.
karkarogachya aushadhache lakshya mhanoon.
enzymatic kriyakalap pii. ell. keey. 4 chya avarodhkanmadhye karkarogachya upcharanmadhye kshamata asate. pii. ell. keey. 4 avarodhak aar. 1530 daun mytotic checkpoint keynage buber 1 chya abhivyaktiche niyaman karato jyamule karkarogachya peshi asthir aanee karkarogachya kemotherapisathi adhik sanvedanshil banatat. yavyatirikt, samanya peshi aar1530 chya polyploidae prerit prabhavanna pratirodhak asatat.
aanakhi eka pii. ell. keey. 4 avarodhak, see. eff. aay.-400945 neey stun aanee andashayachya karkarogachya pranyanchya pratimanmadhye parinamkarakta darshavili aahe.
aanakhi eka pii. ell. keey. 4 avarodhak, centrinon, manvi aanee itar prushthavanshiy peshinchya prakaranmadhil centriol qamee karat asalyache nondavale gele aahe, jyacha parinam jee1 madhye pii53-avalambun asalelya peshi chakr atak honyat jhaala. rasayanik anuvanshik ranniticha vapar karoon pii. ell. keey. 4 chya pratibandhamule jee1 madhye heey pii53-avalambun asalelya peshi chakr atak manya jhaali aahe.
ghatak rabdoid tumour, meduloblastoma aanee bahudha menduchya itar bhrun tumoursathi sambhavya upcharatmak lakshya mhanoon pii. ell. keey. 4 olakhale gele.
parasparsanvad aanee thurr.
dastaivajikaran kelelya pii. ell. keey. 4 tharanmadhye still, jee. see. pii. 6, hand 1, eae. see. tii. 2, eff. bii. ex. doubleu. 5 aanee swatacha (autophosphorylationdware) samavesh aahe. pii. ell. keey. 4 chya autophosphorylationmule sarvavyapita yete aanee tyanantar proteasomecha naash hoto.
pii. ell. keey. 4 haah stratifinshee parasparkriya karato asey disun aale aahe.