
tick-borne encephalitis vishanu

tick-borne encephalitis vishanu (tii. bii. eae. vhee.) haah eka positive-strand aar. aine. aii. vishanu aahe joou 'flavivirus' yaa vanshatil tick-borne encephalitis sambandhit aahe. 
vargikaran.
vargikaran.
tii. bii. eae. vhee. haah 'flavivirus' yaa jaaticha sadasya aahe. itar jawalche natevaik, tbev serocomplexchya sadasyanmadhye "omsk raktasravi taap vishanu", "kayasanur vann rog vishanu", "alkhurma vishanu", "roggrast vishanula sparsh karane" aanee "langat vishanu" yancha samavesh aahe.
upprakar.
tii. bii. eae. vhee. chey teen upprakar aaheth
sandarbh taana mhanje sofjin taana.
vishanushastra.
rachana.
tii. bii. eae. vhee. haah eka sakaratmak-sanvedana asalela ekeri-sapadalela aar. aine. aii. vishanu aahe, joou 40-60 nm golakar, aachchhadit capsidmadhye asato. tii. bii. eae. vhee. genome andaje 11keey. bii. aakaracha aahe, jyamadhye 5 'topi, 3' aanee 5 'yuu. tii. aar. saha ekach khulee vachan chaukat aahe aanee polyadenylsionshivay aahe. itar flaviviruspramanach, tii. bii. eae. vhee. genome daha vishanujanya prathinansathi, teen sanrachanatmak aanee saat gair-sanrachanatmak (aine. ess.) code aahe. 
sanrachanatmak prathine see (capsid), pii. aar. emm. (premembrain) aahet, jee antim puttle prathine, (emm) aanee lifafa prathine (eae) tayar karnyasathi vibhajit kelee jaatat. saat gair-sanrachanatmak prathine aaheth aine. ess. 1, aine. ess. 2 aii, aine. ess. 2 bii, aine. ess. 3, aine. ess. 4 aii, aine. ess. 4 bii aanee aine. ess. 5. kahee gair-sanrachanatmak prathinanchi bhoomika dnyat aahe, aine. ess. 5 aar. aine. aii.-aashrit aar. aine. aii. polymerase mhanoon kaam karate, aine. ess. 3 madhye protease (aine. ess. 2 bii. saha jatil) aanee helicase kriyakalap aahe. genome sansargjanya honyasathi sanrachanatmak aanee gair-sanrachanatmak prathinanchi aavashyakta nasate. serve vishanujanya prathine see, pii. aar. emm., eae, aine. ess. 1, aine. ess. 2 aii., aine. ess. 2 bii., aine. ess. 3, aine. ess. 4 aii., aine. ess. 4 bii., aine. ess. 5 yaa kramane ekach mothe polyprotein mhanoon vyakt kelee jaatat.
rogjanaktela vishanujanya anuvanshik nirdharak.
lifafa prathine receptor-binding aanee neurovirulensemadhye samavisht asatat, jithe vadhaleli glycosaminoglycane-binding aatmiyata neuroenvasiveness qamee karate. aine. ess. 5 prathinanmadhye interferon virodhi kriyakalap asato kaaran teey aay. eff. aine. receptor subunitchya abhivyaktiche niyaman qamee karate. gair-sanrachanatmak prathine 5 (aine. ess. 5) neuritechya vadhichya kshinatedvare neuropathogenesisvar parinam karatat. anuvadit nasalela pradesh 3 (yuu. tii. aar. 3) aanee yuu. tii. aar. 5 heey genomic aar. aine. aii. cyclisation aanee pratikrutivar parinam karatat aanee dendritesmadhil vishanujanya aar. aine. aii. vahtook prabhavit karatat, jyamule neurogenesis aanee synaptic sampreshanavar parinam hoto.
jivanchakra.
prasaran.
jevha eka tick sankramit yajmanakadun rakt sevan karate tevha vahakcha sansarg suru hoto. heey tikchya jivanchakrachya konatyahi bhagat houu shakate parantu sankramit apsara aanee ekach yajmanavar saha-aahar ghenanya asankramit alyanmadhil aadvya sankramanamule tbevche parisancharan rakhane mahattvache manale jaate. yajmananchya raktatil tii. bii. eae. vhee. haah madhyagatachya madhyamatoon tikala sankramit karato, jithun too lalechya granthimadhye jaaun pudhil yajmanakade jaau shakato. praudh nasalelya undaranmadhye, moltingchya darmyan nasht naan jhalelya peshinna sankramit karoon tbev transtadically prasarit hoto, asha prakare tee under ayushyabhar sansargjanya rahate. sankramit praudh under sankramit undy ghalanyas saksham asoo shakatat, jyamule vishanucha sankraman vividh patalyanvar hoto.
pratikruti.
manavanmadhye, sansarg jhalelya tikchya danshachya thikani tvachemadhye (annajany prakarane vagalata, sumare 1 takke sansarg) sansarg suru hoto, jithe tvachetil langerhans peshi aanee macrophages pradhanyane lakshya kele jaatat. tii. bii. eae. vhee. lifafa (eae) prathine yazman peshinchya prushthbhagavaril heparan sulfate (aanee sambhavya itar receptors) olakhatat aanee clathryn madhyasthi margadvare endocytos kelee jaatat. usheera endosomeche aamlikaran eae prathinanmadhye sanrachanatmak badal ghadavun aanate, parinami sanlayan hote, tyanantar uncoating hote aanee ekal-stranded aar. aine. aii. genome peshidravyat sodale jaate. 
vishanujanya polyproteinche bhashantar kele jaate aanee teey air patalat ghatale jaate, jithe yazman peptidesesdware cytosolic bajula aanee vishanujanya enzyme kriyadvare lumenmadhye tyavar prakriya kelee jaate. vishanujanya prathine see, aine. ess. 3 aanee aine. ess. 5 hii cytosolmadhye vighatit hotat (jaree aine. ess. 3 proteolytic kinwa helicase kriyakalap karnyasathi aine. ess. 2 bii. kinwa aine. ess. 4aii. saha guntagunticha houu shakato), tarr urvarit gair-sanrachanatmak prathine air puttle rachana badaltat. haah badallela padada pratikruti sankulanchya ektrikaranas parvanagi deto, jithe vishanujanya januksankalanachi pratikruti vishanujanya aar. aine. aii.-aashrit aar. aine. aii. polymerase, aine. ess. 5 dware kelee jaate. 
navyane pratikruti kelelya vishanujanya aar. aine. aii. genome nantar see prathinandware pack kele jaatat, jevha air patalchya cytosolic bajula, aparipakv nucleocapsid tayar hote aanee eae aanee pii. aar. emm. prathine midavatat, jeey heterodimer mhanoon vyavasthit kele jaatat, erchya lumenmadhye ugavatana. paripakv kananchya tulanet aparipakv virian heey tikshna aanee bhaumitik asate. kann, vadhatya aamleey paristhitit, golgi upkaran aanee "trans"-golgi jaalyatun jaato, jyadvare emm prathin aanee nirmiti sanlayan saksham eae prathin homodimarmadhun pii. aar. vibhagachya vichchhedanane virian paripakv hoto. jaree vighatit pii. aar. vibhag baher padnyaparyant prathine sankulashi sambandhit rahato. 
vahak putika aanee yazman peshi puttle yanche mishran jhalyavar yazman peshitoon vishanu sodala jaato, aata vighatit pii. aar. chey vibhag vegale hotat, parinami eka purnapane paripakv, sansargjanya vishanu tayar hoto. tathapi, anshatah paripakv aanee aparipakv vishanu dekhil kadhikadhi sodale jaatat; aparipakv vishanu sansargjanya nasatat kaaran eae prathine sanlayan saksham nasatat, anshatah paripakv vishanu ajunahi sansarg karnyas saksham asatat.
rogjanan aanee rogpratikarak pratisad.
annajany prakarane vagalata, ticks chavnyachya thikani tvachemadhye sansarg suru hoto. tvachechya dendritic (kinwa langerhans) peshi (dii. see. ess.) pradhanyane lakshya kelya jaatat. suruvatila, vishanu sthanik patalivar pratikruti tayar karato aanee jevha vishanu ghatak cytosolic pattern recognition receptorsdware (pii. aar. aar. ess.) olakhale jaatat, jase qee toll-sarkhe receptors (tii. ell. aar. ess.) tevha rogpratikarak pratisad suru hoto. olakhanyamule interferon (aay. eff. aine.) α, β aanee γ aanee chemokins cytokinesche prakashan hote, jeey sthalantarit rogpratikarak peshi danshachya thikani aakarshit karatat. lakshaniy lakshane disanyapurvi, yaa tappyavar sansarg thambavala jaau shakato aanee too door keela jaau shakato. visheshtah, tick laal yazman rogpratikarak pratisadat badal karoon, apoptotic signal qamee karoon sansarg vadhavate. sansarg suru rahilyas, sthalantarit dii. see. ess. aanee macrophages sankramit hotat aanee sthanik nichara karananya lasika nodmadhye jaatat jithe bahuroopi nuclear leukocytes, monocytes aanee purak pranali sakriy hote.
nichara karnari lasika granthi vishanuche pravardhan sthal mhanoon dekhil kaam karoo shakate, jithun tii. bii. eae. vhee. pranaligat pravesh prapt karate. haah viremic tappa tick-borne encephalitischya prototypical biphasic patternmadhil pahilya lakshanyukt tappyashi sambandhit aahe. neuronal uutinsathi tii. bii. eae. vhee. laa prabal pradhanya aahe aanee teey neuroenvasive aahe. prarambhik viremic tappa anek pradhanyachya uutinmadhye pravesh karnyas anumati deto. tathapi, kendriya majjasansthemadhye (see. aine. ess.) tbev konatya tantrachya madhyamatoon pravesh karato heey spasht nahee. rakt-menduchya adthalyache (bbb) ullanghan karnyasathi anek prastavit yantrana aaheth 1) "trojan horse" yantrana, jyamadhye beebeebeemadhun jaananya rogpratikarak peshila sansarg kartana tbev cnsmadhe pravesh midvate; 2) rogpratikarak peshi cytokinesdware bbbchi vyatyay aanee vadhaleli pargamyata; 3) ghran neuronschya sansargadvare; 4) paridhiy majjatantunsaha cnspryant pratigami vahatukidvare; 5) bbbcha bhag asalelya peshincha sansarg.
see. aine. ess. sansarg european upprakarashi sambandhit abhijat biphasic sansarg paddhatimadhye dusya tappyat aanato. see. aine. ess. rog haah rogpratikarak rog aahe; cytotoxic see. dii. 8 + tii. peshi aanee bahudha aine. keey. peshinchya krutisah dahak cytokinesche prakashan, parinami sankramit peshinchi jaljal aanee apoptosis hote jeey see. aine. ess. chya anek lakshanansathi jababdar asate.
vinodi pratisad.
sansargala pratisad mhanoon tii. bii. eae. vhee. vishisht aay. jee. emm. aanee aay. jee. jee. pratipinde tayar kelee jaatat. aay. jee. emm. pratipinde pratham disatat aanee shikharavar pohochatat, tasech uchch pataliparyant pohochatat aanee samanyatah sansarganantar sumare deed mahinyant nasht hotat, jaree pratyek rugnamadhye lakshaniy farak astitvat aahe. see. aine. ess. chee lakshane dislyanantar sumare 6 aathvadyanni aay. jee. jee. chee patali shikharavar pohochate, nantar kinchit qamee hote parantu nasht hott nahee, jyamule rugnala ayushyabhar pratikarshakti milate.
utkranti.
vidyaman prabhedancha purvaj andaje 2750 varshanpurvi anek vanshanmadhye vibhakt jhalyache disate. cyberian aanee sudur purvekadil upprakar sumare 2250 varshanpurvi vegale jhaale. dusare vishleshan, utkrantichi purvichi tarikh (3300 varshanpurvi) suchavate, jyat sumare 300 varshanpurvi suru jhalelya prabhedanchya sankhyet zapatyane vaadh jhaali aahe. vishanuche vegvegale prabhed varshapurvichya 260-430 darmyan japanmadhye kiman teen vela sankramit jhaale aahet. laviamadhye pasarnare prabhed russia aanee paschim europe yaa donhi deshanmadhun udbhavalyache disate, tarr estoniyatil prabhed russiamadhye ugam pavalyache disate. lithuania prabhed paschim europemadhil prabhedanshi sambandhit asalyache disate. jatijanya vishleshan asey soochit karate qee european aanee cyberian tbeve upprakar jawalche sambandhit aahet tarr sudur-purv upprakar looping aajari vishanuchya jawal aahe. tathapi, eae, aine. ess. 3 aanee aine. ess. 5 prathinanvar aadharit pratijan sambandhitatemadhye, tinhi up-prakar atyant samaan aahet aanee roggrast vishanula lauping karane haah samoohik tii. bii. eae. vhee. gatachya bahercha sarvat jawalcha sapeksh aahe.
itihas.
jaree 1700 chya dashakat scandinaviatil nondinmadhye tii. bii. eae. chey pahile varnan disun aale asale, taree 1930 chya dashakat soviet unionmadhye tii. bii. eae. vhee. vishanuchi olakh jhaali. japani samrajyachya (sadhyache peaples republic auph chayana) simevar, sudur purvekadil shahar khabarovskajaval tainat asalelya soviet sainyat, japani encephalitis (unhali encephalitis) asalyache manale jaat asalelya udrekamule tapas suru jhaala. yaa mohimeche netrutva vishanushastradnya lev aii yanni kele hote. zilber yanni accrology, microbiology, neurology aanee epidemiology yasarkhya anek sambandhit kshetranmadhye vees tarun shastradnyancha eka gut tayar keela. hii moheem 15 meey 1937 roji khabarovsk yethe pohochali aanee elizabeth aine. yanchya netrutvakhali uttarekadil tukadyanmadhye vibhagali gelee. levkovich aanee khabrowski kraimadhye kaam karat aahe-aanee dakshinekade alekzandr dii. sheboldeva, primorsky kraimadhye kaam karate. 
meey mahinyachya aat, mohimene sambhavya vahak mhanoon bagaichi olakh patavali hotee, jee gola kelee hotee "i. kitakshastradnya alekzandar vhee. yanni ughadya tvachechya samparkat aalyane persucates 'tick' hoto. gatsevich aanee vishanushastradnya mikhail pii. chumakovne jaanunbujun sankramit undaranna khanari undaranpasun vishanu vegala keela hota. unhalyat, mohimetil paach sadasyanna tbevchi lagan jhaali aanee konatahi mrutyu jhaala nasla taree, pachpaiki teen sadasyanna nukasankarak sequelcha samna karava lagla. 
augustchya madhyat hii moheem parat aalee aanee aktoobar 1937 madhye zilber aanee sheboldovala atak karnyat aalee, tyanchyavar japani encephalitis pasaravalyacha khota aarop karnyat aala. moheem mahamarishastradnya tamara emm. silber aanee sheboldova yanchyaviruddhachya aaropancha nishedh kelyabaddal pudhil jaanevarit safonovla atak karnyat aalee. atakecha parinam mhanoon, mohim acarologist, vasily ess. yanchya lekhanakhali eka mahattvapoorn prarambhik karya prakashit jhaale. mironov. zilber 1939 madhye pradarshit jhaala aanee sheboldovas yaa prarambhik kamache saha-lekhakatva punarsanchayit karnyat yashasvi jhaala; tathapi, safanov aanee sheboldovane (jyanna sodanyat aale navhate) kamgar shibiranmadhye 18 varshe ghalavali.