aine-ethylmelimide

"aine"-ethylmelimide (neem) heey eka sendriya sanyug aahe jeey mallic esidpasoon tayar kele jaate. tyat emide karyatmak gut asato, parantu tyahoon mahattvache mhanje too eka alkin aahe joou thiolschya dishene pratikriyashil asato aanee samanyatah prathine aanee peptidesmadhil cysteine avasheshanmadhye badal karnyasathi vaparla jaato.
sendriya rasayanshastra.
maikal abhikriyemadhye neem haah maykal swikaranara aahe, jyacha arth assa aahe qee too thiolsasarkhya nucleophileschi bharr ghalato. parinami tayar tayar theothermadhye eka majboot see-ess bandh asato aanee pratikriya aksharshah aparivartaniy asate. thiols pratikriya ph shreni 6.5-7.5 madhye hote, neem amines pratikriya deu shakate kinwa adhik alkadharmi phvar jalvichhedan karoo shakate. utsechakshastratil thayol gatanchya karyatmak bhoomikechi tapasani karnyasathi nemcha mothya pramanat vapar keela jaato. neem haah serve cysteine peptidesescha aparivartaniy avarodhak aahe, jyamadhye sakriy site thayol gatavar alkylation hote (yojnabaddha pahaa). 
prakaranancha abhyas.
neem heey putkulya vahtook rokhate. lysis buffersmadhye, western blot vishleshanasathi prathinanche dii-sumoilation rokhanyasathi 20 teey 25 miimii kadunimbicha vapar keela jaato. deubiquitinesche avarodhak mhanoonahi kadunimbicha vapar keela gela aahe.
"arther cornberg aanee tyanchya tyanchya dii. aine. aii. polymerase III baher kadhanyasathi aine.-ethylmelimidecha vapar keela, jenekarun tyachya kriyakalapanchi tulana dii. aine. aii. polymerase I (pole III aanee I, anukrame) shhee kelee jaau shakate. pole aayacha shodh lavlyabaddal cornbergla nobel paritoshik denyat aale hote, jeey nantar jivanu dii. aine. aii. pratikrutichi yantrana manale jaat hote, jaree yaa prayogat tyane dakhavun dile qee pole III hii vastavik pratikruti yantrana hotee.
kodulimbachi qamee patali asalelya mendhya aanee aanee laal raktpeshinmadhye oaben-asanvedanshil see. ell.-dependent keey. efflux sakriy karate. yaa shodhamule 16 varshannantar keey. see. see. 1 isophorm see. dii. aine. aii. dware sankramit jhalelya manvi bhrun peshinmadhil keey-see. ell. cottransportchya (keey. see. see.) aanvik olakheet yogdan midale. tevhapasoon, prani samrajyatil anek prajatinchya peshinmadhye keey-see. ell. cottransportchya padadyachi upasthiti ughad karnyasathi kinwa hatalanyasathi eka nidan sadhan mhanoon nemcha mothya pramanat vapar keela jaat aahe. lakshya theol gut rasayanikdrushtya olakhanyache varanvar ayashasvi prayatna karoonahi, sharirik ph yethe, neem prathinanchya kinesamadhye theols jodani tayar karoo shakate jeey phosphorylate kcc vishisht serine aanee threonin avashesh pramukhyane vahakachya see-terminal domenmadhye asatat. prathine phosphetasdware kesisiche parinami honare defosphorylation kesisichya sakriyatekade netat.

