
vish 3

toxes 3 mhanoonahi olakhale jaanare toxes hye mobility gut boxes kutumbatil sadasya 3 heey manvi januk aahe.
yaa janukadware encode kelele prathine heey pratilekhan ghatakanchya upkutumbatil sadasya aahet jyat "toxes", "toxes 2" aanee "toxes 4" dekhil samavisht aahet jeey jawaljawal samaan etch. emm. jee.-boxes dii. aine. aii.-binding domain samayik karatat jeey dii. aine. aii. laa shithil karoon aanee vakavoon chromatin sanrachanet badal karnyache karya karatat. cag punaravruttimule prathin toxes 3 madhye glutamineukt see-terminus asato. "toxes 3" haah manvi gunasutra pattyavar 16q12.1 sthit aahe. janukamadhye saat exon asatat aanee mendu aanee luminal epithelial stanachya uutinmadhye teey atyant vyakt hote. janukatil utparivartan heey stanachya karkarogachya vadhatya sanvedanshilateshi sambandhit aahet. "toxes 3" calcium-aadharit pratilekhan niyantrit karnyat bhoomika bajavate aanee camp-pratisad-ghatak-bandhan prathine (crabe) aanee crabe-bandhan prathine (see. bii. pii.) yanchyashi sanvad sadhate. heey uddhrut 1 saha-niyantrak, jeey pratilekhan ghatak kriyakalap vadhavate, yachyashi parasparsanvad sadhun pratilekhan dekhil vadhavate.
rogacha sambandh.
toxes 3' janukatil utparivartan stanachya karkarogachya vadhiv jokhamishi sambandhit aahet.
jokhamiche elil aar. ess. 3803662 heey qamee-pravesh karnare ess. aine. pii. (ekal nucleotide bahurupata) aahe jeey 'toxes 3' chya qamee jhalelya abhivyaktishi aanee stanachya karkarogachya jokhamimadhye vadhis karanibhoot aahe. jokhim locus chromatineshee bandhale jaanare "foxa 1" chey aakarshan niyantrit karate, jyamule sambhavyatah "toxes 3" abhivyaktivar parinam hoto. haah sthan jokhim vadhavanyasathi uchch-pravesh utparivartananshi "bii. aar. see. aii. 1" aanee "bii. aar. see. aii. 2" saha dekhil parasparkriya karato. aar. ess. 3803662 prakarachi loksankhyet uchch varanvarta aahe, jyamadhye 0.25 chya kirkol elil varanvartesaha.
toxes 3' chya pratilekhan yantrana aanee prathinanchya parasparsanvadabaddal phaar qamee mahitee aahe. tathapi, 2019 chya eka prakashanane 'toxes 3' laa spasht peshi mootrapind peshi carcinomamadhye (see. see. aar. see.) karkarog dadapavanara januk mhanoon olakhale aanee asey nondavale qee 'toxes 3' chey qamee niyaman 'snay1' aanee 'snay2' chey dadapshahi qamee karoon upakala messenkimal sankraman sulabh karate, parinami gaath vadhate aanee metastasis hote. stanachya karkarogapramanech, 'toxes 3' chey qamee niyaman heey see. see. aar. see. see. rugnanmadhye white purvasuchanashi sambandhit aahe.