ell. aar. aar. aine. 3

lucine-samruddha punaravrutti neuronal prathine 3, jyala neuronal lucine-samruddha punaravrutti prathine 3 (aine. ell. aar. aar.-3) asehi mhanatat, heey eka prathine aahe jeey manavanmadhye "ell. aar. aar. aine. 3" janukadware encode kele jaate.
januk.
ell. aar. aar. aine. 3 haah manvi gunasutra 7 varr, 7q31.1 varr sthit aahe. tyat 6 bhinn jee. tii.-aii. jee. intron asatat aanee pratilekhan paach bhinn emm. aar. aine. aii. tayar karate jeey 3 'toke kapoon vegale disatat. ell. aar. aar. aine. 3 prathinansathi pratyakshat encode karnare keval teen mukhya pratilekhan prakar aahet, jyat sarvat lamb pratilekhan prakar 3744 bases jodya lambicha aahe. yaa tinhi pratilekhan prakaranchi lambi aanee exonchi sankhya vegvegali aahe, parantu tyaa sarvanmadhye exon aahe jyamadhye jyamadhye prathinansathi sampoorn coding kram samavisht aahe. ell. aar. aar. aine. 3 janukasathi done samantar dekhil aahet. yamadhye ell. aar. aar. aine. 1 aanee ell. aar. aar. aine. 2 janukancha samavesh aahe, jyaa donhimadhye samaan lucine-samruddha punaravrutti aahet jee janukanchya yaa kutumbache vaishishtya aahe.
prathine.
ell. aar. aar. aine. 3 prathinanchi lambi 708 amino acid asate. yaa prathinanche aanvik vajan 79,424 daltons aahe, jyacha isoelectric bindu 8.02 aahe. heey eka-paas prakarche aay membrain protein mhanoon olakhale jaate kaaran teey padadyala ekada pasarvate, aanee tyache aine-terminal padadyachya bahya koshikeey bajula asate aanee tyacha signal kram kadhoon takala jaato.
ell. aar. aar. aine. 3 prathinanmadhye ell. aar. aar. aine. tii. aanee ell. aar. aar. aar. aay. domens 12 lucine-samruddha punaravrutti asatat. leucinyukt punaravruttimadhye hydrophobic amino acid lucine asamanyapane samruddha asate. teey prathine-prathine parasparsanvadachya rupanmadhye samanya aahet aanee samanyatah 20-29 amino acid lambiche asatat. ell. aar. aar. chya serve pramukh varganmadhye avtal bajula samantar beeta patrak aanee uttal bajula bahutek helical ghatak asaleli vakr ghodyachya nalyachi rachana asalyache dnyat aahe. ell. aar. aar. aine. 3 prathinanmadhye immunoglobulin kshetra, fibronectin prakar III kshetra aanee prathinanchya shevati transmembrane kshetra dekhil asate. yaa prathinanchi rachana khalee darshavili aahe.
januk sanwardhan.
ell. aar. aar. aine. 3 januk atyant sanrakshit asalyache disun aale aahe. zebra mashankade parat parat yaa janukasathi 21 ortholog aanee homolog aahet. heey januk konatyahi aksheruki kinwa vanaspati prajatinmadhye aadhalalele nahee. anek vegvegalya prajatinmadhye ell. aar. aar. aine. 3 janukache heey atishay uchch sanwardhan bahuvidh anukramanchya sanrekhanane darshavile aahe. leukinyukt punaravrutti asalelya serve 12, ell. aar. aar. aar. tii. aanee ell. aar. aar. aar. rii. pradeshansah, serve prushthavanshiy pranyanmadhye atyant sanrakshit aahet jyasathi yaa prathinanche ortholog prapt kele gele aahet. aay. jee. aanee eff. aine. 3 kshetranmadhye sastan prani aanee pakshyansathichya serve orthologous anukramanmadhye uchch sanwardhan dekhil disun yete, parantu urvarit homologous anukramansathi teey titke sanrakshit naheet. lucine-samruddha punaravrutti, aay. jee. domain aanee eff. aine. 3 domenche uchch sanwardhan heey darshavate qee heey pradesh ell. aar. aar. aine. 3 janukanchya karyakshamatesathi mahattvache asale pahijet.
januk abhivyakti.
januk abhivyaktichya aakadevarivarun asey disun aale aahe qee ell. aar. aar. aine. 3 januk manavanmadhye khoop uchch staravar vyakt hote, jeey sarasari janukapeksha sumare 2.3 putt jaast aahe. mendu, hriday aanee vrushananchya uutinmadhye heey sarvadhik vyakt hote. mootrapind, snayu, ghasa, garbhakosh aanee thymus uutinmadhyehi heey kinchit vyakt hote. vikasachya tappyansathi ell. aar. aar. aine. 3 janukachi sarvoch abhivyakti mhanje garbh avastha, parantu tee arbhak, kishore aanee praudh avasthanmadhye dekhil vyakt kelee jaate, jee ist profilemadhye pahili jaau shakate.
ell. aar. aar. aine. 3 janukasathichya abhivyakti mahitivarun asey disun yete qee mendumadhye tyachi abhivyakti sarvadhik aahe. ekandarit, menduchya bahutek uutinmadhye ell. aar. aar. aine. 3 januk uchch teey madhyam abhivyakti asalyache disate. sarvat jaast abhivyakti cerebral cortex, hippocampal nirmiti, cerebeller cortex aanee parafloculusmadhye aadhalate. heey serve pradesh kahee pramukh sandnyanatmak karyat bhoomika bajavtat, jyat bhasha aanee sanvedanatmak uttejana, smaranshakti aanee auculomotor vartanachi prakriya samavisht aahe. menduchya yaa bhaganmadhye ell. aar. aar. aine. 3 janukachi uchch abhivyakti heey darshavu shakate qee ell. aar. aar. aine. 3 janukache yaa sandnyanatmak karyat kahee mahatva aahe.
rachana.
leucinyukt punaravrutti prathinancha vaishishtyapurn aakar mhanje kamani kinwa ghodyachya nalyacha aakar. prathinancha haah ghodyachya nalyacha aakar avtal bajuchya samantar beeta sheetdware aanee bahutek vela bahirmukh bajuchya helical ghatkandware tayar keela jaato. beeta-strand aanee lagatchya loop kshetranshi sambandhit ell. aar. aar. ess. chey akra avashesh bhag ell. aar. aar. prathinanmadhye sanrakshit kele jaatat, tarr punaravruttiche urvarit bhag bhinn asoo shakatat. avtal chehara aanee lagatche loop heey ell. aar. aar. prathinanvaril sarvat samanya prathin parasparsanvad prushthbhag aahet. kahee ell. aar. aar. prathine-legand sankulanchya sankulanchya sanrachananmadhun asey disun yete qee ell. aar. aar. kshetrachi avtal prushthbhagiy rachana hii alfa-helixshee sanvad sadhanyasathi aadarsh aahe, asha prakare, lamb aanee vakr ell. aar. aar. rachana vividh prathine-prathine parasparsanvad sadhya karnyasathi eka chaukat pradan karate yaa nishkarshala samarthan dete.
ell. aar. aar. aine. 3 prathinanchi, lingo 1 ectodomenchya sphatik sanrachanechya sakhali aaa shhee tulana kelyas asey disun yete qee ell. aar. aar. aine. 3 prathin bahutek lucine-samruddha punaravrutti prathinanchya ghodyachya nalyachya vaishishtyapurn aakaravar ghete. lingo 1 ectodomenmadhye lucine-samruddha punaravrutticha khoop lamb vistar dekhil asato joou lrrn 3 prathinanshi sarvottam sanrekhan asalela pradesh aahe. yaa samaan pradeshatoon asey disun yete qee ell. aar. aar. aine. 3 prathinanchi eka rachana aahe jyamadhye bahutek beeta-strands asatat jeey loopsdware jodalele asatat, jyat kahee alfa helices asatat.

