cycline-aashrit keynage 4

cycline-dependent kinez 4, jyala peshi vibhajan prathine kinez 4 asehi mhanatat, heey eka enzyme aahe jeey manavanmadhye "see. dii. keey. 4" janukadware encode kele jaate. see. dii. keey. 4 haah cycline-aashrit keynage kutumbatil sadasya aahe.
karya.
yaa janukadware encode kelele prathine heey sair/thra prathine keynage kutumbatil sadasya aahet. hii prathine esachya januk utpadananshi khoop samaan aahet. sereviciae sereviciae aanee ess. pombe "see. dii. see. 2. heey protein keynage complexche utprerak upghatak aahe jeey peshi chakr chakr tappyachya pragatisathi mahatvache aahe. yaa kinezchi kriya kriya tappyaparyant maryadit aahe, jeey niyamak upghatak dii-prakar cyclins aanee see. dii. keey. avarodhak cyclincyiinq4aii. dware niyantrit kele jaate. haah kinage retinoblastoma januk utpadanachya (aar. bii.) phosphorylationsathy jababdar asalyache darshavile gele. cycline cycline (dc) sankulatil sair/thra-keynage ghatak jeey phosphorylate karatat aanee aanee saha retinoblastoma (aarbi) prathine kutumbatil sadasyanna rokhatat aanee aanee sankramanadarmyan peshi-chakr niyantrit karatat. aar. bii. 1 chey phosphorylation aar. bii./eae. 2. eff. sankulanmadhun pratilekhan ghatak eae. 2. eff. chey pruthakkaran aanee tyanantar jee. 1 tappyatil pragatisathi jababdar asalelya eae. 2. eff. lakshya janukanche pratilekhan karnyas anumati dete. chakrachyyaa suruvatichya tappyat hypophosphorylates aar. bii. 1. cycline cycline sankul heey vividh mitogenic aanee antimetogenic sanketanche pramukh samakalak aahet. tasech peshi-chakr-aadharit paddhatine phosphorylates smad 3 karatat aanee tyachya pratilekhan kriyakalapanna dadapatat. tri-stariy sankulacha ghatak, cycline dii/see. dii. keey. 4/see. dii. keey. aine. 1. bii., haah cycline dii-see. dii. keey. 4 sankulachya anoo sthanantar aanee kriyakalapansathi aavashyak aahe.
vaidyakeey mahatva.
yaa janukatil tasech dii-prakarchya cyclins, cyclins pii16, see. dii. aine. aine. 2aii aanee aar. bii. yasah tyachya sambandhit prathinanmadhil utparivartan heey serve vividh prakarchya karkaroganchya tumerginesishi sambandhit asalyache aadhalun aale. see. dii. keey. 4 (aar. 24. see.) chey eka vishisht bindu utparivartan pratham melanomachya rugnanmadhye olakhale gele. heey utparivartan pranyanchya pratikrutinmadhyehi sadar karnyat aale aanee karkarog chalak oncogene mhanoon tyachya bhoomikecha sakhol abhyas karnyat aala. aajkal, kahee karkarog prakaranmadhye aniyantrit see. dii. keey. 4 heey sambhavya upcharatmak lakshya manale jaate aanee vaidyakeey chachanyanmadhye karkarogachya upcharasathi vividh see. dii. keey. 4 avarodhakanchi chachani kelee jaat aahe.
yaa janukachya anek polyadenylication siteschee nond karnyat aalee aahe.
teey cycline dii dware niyantrit kele jaate.
avarodhak.
istrogen receptor receptor negative pragat stanachya karkarogachya upcharasathi ribosiclib heey yuu. ess. eff. dii. aii. neey manyataprapt see. dii. keey. 4 aanee see. dii. keey. 6 avarodhak aahet.
vividh see. dii. keey. chya avarodhkansathi see. dii. keey. avarodhak dekhil pahaa.
parasparsanvad.
cycline-aashrit kinez 4 yachyashi parasparkriya jhalyache disun aale aaheh

