
zedasi3etch11bii

zink finger mhanoonahi olakhale jaanare zedasi3etch11bii heey 11bii prathine asalele see. see. see. etch.-prakar manavanmadhil eka prathine aahe jeey zedasi3etch11bii janukadware encode kelele aahe. zedasi3etch11bii januk gunasutra 1 varr, lamb bahuvar, band 4 vibhag 1 madhye sthit aahe. yaa prathinala zedasi3echadisi11bii asehi mhanatat. zed. see. 3etch. 11bii januk ekoon 5,134 kshar jodya lamb asate aanee prathine 805 amino aaml lambichi asatat. zed. see. 3etch. 11bii janukamadhye ekoon 2 exon asatat.
karya.
zed. see. 3etch. 11bii prathine vrushan, hriday, paay aanee adhivrukkasaha vividh uutinmadhye vyakt kelee jaatat. electronic sambandhatun andajit kelyapramane, dhatoo aayan kinwa chillationchya sanyojanacha samavesh asalelya dhatoo aayan bandhanamadhye zedasi3etch11beachaaa samavesh asalyacha andaj vartavala jaato.
rachana.
kshetra.
zed. see. 3etch. 11bii prathinanmadhye teen sanrakshit kshetra aahet. yamadhye zink finger domencha samavesh hoto, jeey bahutekda cellular prakriyanchya niyamanat guntalele sarvat samanya kinwa mubalak prathin gut aahet aanee coil coil domain, jeey sanrachanatmakdrushtya sanrakshit prathin gut aahet jeey jivanachya serve kshetranmadhye asatat, jeey bahutekda aanvik antar, putika tethering aanee dii. aine. aii. olakh aanee phoot yamadhye guntalele asatat. zink boat aanee gundallelya gundalyanchi donhi kshetre eukeriotsmadhye sanrakshit kelee jaatat.
zink finger see3etch1-prakar 1 haah amino acid 2-29 pasoon aadhalato aanee zink finger see3etch1-prakar 2 haah amino acid 31-57 pasoon aadhalato. zink finger see3etch1-prakar prathine anuvadit naan kelelya mrnhya 3 'pradeshashi parasparkriya karnyasathi olakhali gelee aahet. gundalaleli gundali prathinanchya 403-423 amino aesidchya sthananvar sthit asate.
duyyam.
sadhya zedasi3etch11beachii duyyam rachana adnyat aahe.
zedasi3etch11beachii andajit duyyam rachana hii eka loop duyyam rachana rachana aahe, jee aniyamit duyyam sanrachana aahet jee done duyyam sanrachanatmak ghatakanna jodatat aanee polypeptide sakhali prasarachi disha badalanyas saksham aahet. loop bandhanisathi ughad hoil assa andaj vartavala jaato.
anuvadanantarche badal.
zedasi3etch11bii heey bahudha kendrakamadhye aadhalate. zedasi3etch11bii vividh phosphorylation, oo-glackenesilation, glycation aanee oo-glycosylationmadhun jaeel assa andaj vartavala jaato.
phosphorylationsathy andajit sthalanchi udaharane, jyamadhye phosphoril gut jaivik niyaman aanee itar cellular prakriyanmadhye jodala jaato aanee mahattvacha asato, tee yantrana 108,149,196,229,290 aanee 330 roji udbhavate. oo-glackenecillationsathy andajit sthalanchi udaharane, eka yantrana jyamadhye oo-linked aine-acetylglucosamine (oo-glackenack) jodale jaate aanee cellular prakriyanchya niyamanasathi mahatvache aahe, tee 488,744 aanee 732 aahet. glycationsasathi andajit sthalanchi udaharane, eka yantrana jyamadhye glucose prathine aanee lipidshee bandhate, tee 140,359,669 aanee 776 aahet. oo-glycosylationsathy andajit sthalanchi udaharane, eka yantrana jyamadhye sharkara kinwa monosecharides hydroxyl gatanmadhye jodatat, 1796 aanee 386 varr udbhavtat.
samarupata.
vividh sastan prani, keetak aanee ubhaycharansah vividh prajatinmadhye zedasi3etch11bii prathinanche anek olakhale gelele samaroop aahet.
paralog.
sadhya, blast analysisver (aine. see. bii. aay.) aadharit tyach see. see. see. etch.-prakarchya zink finger kutumbat zed. see. 3etch. 11bii. chee eka paralog aahe.
c12orf50 ("h. sapiens) "chaa andaj dekhil zedasi3etch11beachaaa eka paralog mhanoon vartavala gela aahe.
orthologs.
anek prajati aahet jyaa tyanchya genomemadhe zedasi3etch11bii prathinansathi ortholog asalyache blast analysisver (aine. see. bii. aay.) aadharit asalyache aadhalun aale aahe.
zc3h11a ("b. vrushabh "), zc3h11a (" m. musculus), zedasi3etch11aii (aar. norwegicus), zedasi3etch11aii (jee. gallus "), zc3h11a, (" x. ushnakatibandhiy), zedasi3etch11aii (dii. rerio "), 2g02160 (" aaa. thaliana "), zedasi3etch11aii (" mea. domesticia "), zedasi3etch11aii (" aaa. carolinensis), aanee zedasi3etch11aii (ess. scropha ") chaa andaj zc3h11b chey ortholog mhanoon dekhil vartavala gela aahe.
vaidyakeey mahatva.
sadhyachya sanshodhanat zedasi3etch11bii heey eka-nucleotide bahurupata (snps) mhanoon olakhale gele aahe jeey uchch drushti aanee parpatalachya drushtivaishamya asalelya gatanmadhye sarvat samanya anuvanshik bhinnata aahet. april 2020 paryant, zedasi3etch11beela itar attinshi jodanare itar konatehi prakashit association abhyas jhalele naheet.
myopia.
myopia, jyala drushtidosh kinwa nikatadrushti asehi mhanatat, hii eka ashee sthitee aahe jee apavartak trutimule hote jyamadhye dolhyacha aakar ektar lamb asato kinwa parpatalacha aakar khoop vakr asato. vikasit deshanmadhye, hii sthitee purv aashiyatil praudhanmadhye (80-90%) honanya ghatanancha uchch darr asalelya 50 takkyanhun adhik loksankhyemadhye udbhavate aanee americetil andaje 30 takke loksankhyet udbhavate.
myopiyache done gatanmadhye vargikaran kele jaate. jyapaiki pahilya bhagat qamee teey madhyam pramanat myopia kinwa sadhya myopia asalelya lokancha samavesh asato aanee 0 teey-6 diaptersver nidan kele jaate aanee sudharatmak lensney upchar kele jaatat. dusyache uchch drushtibhransh mhanoon vargikaran kele jaate aanee-6 peksha jaast dioptersmadhye tyache nidan kele jaate aanee samanyatah drushtipatalatil vilgikaran, mccular degeneration aanee kachbinduchya prakarananmadhye aadhaltat. jaagtik aarogya sanghatnene andhatva aanee drushtidoshachya jagatil pramukh karananpaiki eka mhanoon myopia manale aahe.
dirgh netra aksheey lambi (all), kinwa agravarti parpatalachya prushthbhagapasun retinal pigment epitheliumparyantche antar, haah myopiyachya vikasacha nirdharak aahe. chiinii praudh aanee mule tasech malay praudhanchya loksankhyemadhye kelelya genome-wide association abhyasat asey aadhalun aale qee zedasi3etch11bii haah all aanee uchch myopiyashi sambandhit aahe. mendu, naal, majjatantuche padade, drushtipatal rangdravya epithelium aanee scleramadhye zedasi3etch11bii emm. aar. aine. aii. abhivyakti patali hotee, jyat myopic nasalelya dolhyanpeksha myopic dolhyanmadhye pramanat jaast ghat jhaali kinwa abhivyakti patali qamee jhaali. yaa olakhichi pushti dusarya genome-wide association abhyasat aar. ess. pii. oo. 1 (doubleu. aine. tii. signalling kinwa netragolakachya aakarachya niyamanat sameel), see. 3. corf. 26, zed. aine. aar. eff. 3 (doubleu. aine. tii. signalingmadhye sameel) aanee ell. pii. ell. 2 sathee atirikt mahattvapoorn sthan olakhanyasah jhaali. asha prakare, samayik sambandh asalelya all janukanchi hii olakh soochit karate qee all aanee apavartan vegvegalya optic marganmule houu shakate. yavyatirikt, chiinii loksankhyetil genome-wide association abhyasane pushti kelee qee zedasi3etch11bii heey uchch aanee atyant myopiyachya vikasasathi eka sanvedanshil januk aahe.
drushtivaishamya.
drushtivaishamya hii eka ashee sthitee aahe jyamadhye parpatalachi kinwa lenschi vakrata asamanya asate. drushtivaishamyala parpatli drushtivaishamya asey vargikrut kele jaau shakate jyamadhye parpatalicha aakar aniyamit asato, lenticular drushtivaishamya jyamadhye lenscha aakar aniyamit asato kinwa apavartak drushtivaishamya. drushtivaishamyavar samanyatah sudharatmak lains kinwa shastrakriyedvare (jase qee lasik) upchar kele jaatat.
apavartak aanee parpatalachya drushtivaishamyamule upchar naan kelyas andhadrushti kinwa aalashi dolha vikasit houu shakato. european vanshachya vyaktinchya genome-wide association abhyasane zedasi3etch11bii januk heey parpatalachya drushtivaishamyasathi mahattvapoorn asalyache olakhale. yavyatirikt, parpatli drushtivaishamyasathi genome-vyapi mahattvapoorn sambandh darshavinyasathi aanakhi done sthanke olakhali gelee, herk 2 aanee teaspan 10/aine. pii. ell. oo. see 4.