pratipind-avalambun cellular cytotoxicity

pratipind-aashrit cellular cytotoxicity (aii. dii. see. see.), jyala pratipind-aadharit peshi-madhyasthi cytotoxicity asehi mhanatat, hii peshi-madhyasth rogpratikarak sanrakshanachi eka yantrana aahe jyamadhye rogpratikarak pranalichi prabhavi peshi lakshyit peshi marte, jyachi padada-prushthbhagavaril pratijan vishisht pratipindandware bandhaleli asatat. hii eka ashee yantrana aahe jyadvare pratipinde, hasyamay rogpratikarak pratisadacha bhag mhanoon, sansarg maryadit karnyasathi aanee niyantrit karnyasathi karya karoo shakatat.
aii. dii. see. see. rogpratikarak purak pranalipasoon swatantra aahe jee lakshyanparyant pohochate parantu itar konatyahi peshichi aavashyakta nasate. aii. dii. see. see. laa eka prabhavi peshi aavashyak asate jee shastriyadrushtya naisargik ghatak (aine. keey.) peshi mhanoon olakhali jaate jee samanyatah immunoglobulin jee. (aay. jee. jee.) pratipindanshi sanvad sadhatat. tathapi, macrophage, neutrophils aanee eosynophils dekhil aii. dii. see. see. madhye madhyasthi karoo shakatat, jase qee eosynophils aay. jee. eae. pratipindandware helminth mhanoon olakhalya jaanarya kahee parjivi krumincha naash karatat.
sarvasadharanpane, aii. dii. see. see. chey varnan samanyatah pratipinde-lepit peshinna rogpratikarak pratisad mhanoon kele gele aahe, jyamule shevati sankramit kinwa gair-yazman peshiche astikaran hote. alikadchya sahityat, karkarogachya peshinchya upcharanchya sandarbhat tyache mahatva aanee tyachya fasavya guntaguntichya margambaddal sakhol antardrushti heey vaidyakeey sanshodhkansathi vadhatya ruchiche vishay rahile aahet.
aine. keey. peshi.
vishisht aii. dii. see. see. madhye rogpratikarak niyantranachya bahustareey pragatimadhye pratipindandware aine. keey. peshi sakriy karane samavisht asate. eka aine. keey. peshi eff. see. jee. emm. receptors vyakt karate. heey receptors aay. jee. jee. sarkhya pratipindachya paraspar bhagala olakhatat aanee bandhatat, joou rogjankanchya sankramit lakshya peshinchya prushthbhagala bandhato. aine. keey. peshinchya prushthbhagavaril yaa eff. see. receptorspacky sarvat samanya see. dii. 16 kinwa eff. see. jee. aar. aay. aay. aay. aahe. ekada eff. see. receptor pratipindachya eff. see. kshetrashi jodale gele qee, aine. keey. peshi cytotoxic ghatak sodate jyamule lakshyit peshicha mrutyu hoto.
vishanuchya pratikrutichya darmyan, kahee vishanujanya prathine sankramit peshinchya peshi prushthbhagachya padadyavar vyakt kelee jaatat. tyanantar pratipinde yaa vishanujanya prathinanshi jodali jaau shakatat. pudhe, paraspar eff. see. jee. emm. receptors asalelya aine. keey. peshi tyaa pratipindeshi bandhalya jaatil, jyamule aine. keey. peshila perforin aanee gransimes mhanoon olakhalya jaanarya protease sarkhya prathine sodanyas pravrutt karel, jyamule sankramit peshichya laysisamule vishanucha prasar rokhata yeil.
eosynophils.
helminthsarkhe mothe parjivi itake mothe asatat qee teey phagocytosisne vyapale jaau shakat naheet aanee marle jaau shakat naheet. tyanchi eka bahya rachana kinwa purnank dekhil aahe joou neutrophils aanee macrofagesdware sodanyat aalelya padarthanchya hallyas pratirodhak aahe. yaa parjivinna aay. jee. eae. coat lavlyanantar, eosinophilcha eff. see. receptor (eff. see. reeree.) aay. jee. eae. olakhel. tyanantar, eff. see. eae. aar. aanee helminth-bound aay. jee. eae. chaa eff. see. bhag yanchyatil parasparkriya eosinophilache avakshay honyache sanket dete.
"inn vitro" parikshan.
aii. dii. see. see. baher kadhanyasathi pratipinde kinwa prabhavi peshinchi parinamkarakta nirdharit karnyasathi anek prayogshala paddhati astitvat aahet. samanyatah, prushthbhagavar disanari vishisht pratijan vyakt karnari lakshya peshi resha tyaa pratijanasathi vishisht pratijanansah ubavali jaate. dhuun ghetalyanantar, eff. see. receptor see. dii. 16 vyakt lakshya prabhavak peshi pratipind-label kelelya lakshya pesheensah saha-ushmayit kelya jaatat. prabhavi peshi samanyatah pii. bii. emm. see. (paridhiy rakt mononuclear peshi) asatat, jyapaiki eka lahan takkewari aine. keey. peshi (naisargik ghatak peshi) asatat; qamee vela tyaa swatah shuddha kelelya aine. keey. peshi asatat. kahee tasanchya kalavadhit pratipinde, lakshya peshi aanee parinamak peshi yanchyat eka jatil rachana hote jyamule lakshyit peshichya patalavar astar hoto. jarr lakshyit peshivar kahee prakarche label aadhich bharalele asel, tarr teey label peshi lisisachya pramananusar sodale jaate. nirogi, akhand peshinmadhye rahilelya labelchya pramanachya tulanet dravanatil labelche praman mojoon cytotoxicityche praman mojale jaau shakate.
heey shodhanyachi shastriy paddhat mhanje chromium-51 [51cr] mukti parikshan; sulfur-35 [35s] mukti parikshan haah thoda vaparla jaanara radioisotope-aadharit paryay aahe. lakshya peshi lysis heey gamma counter kinwa cintilation counterchya madhyamatoon peshi sanwardhan madhyamat sodanyat aalelya radiolableche praman mojoon nirdharit kele jaate. vividh prakarchya gair-kiranotsargi paddhati aata mothya pramanavar vaparat aahet. pratidipti-aadharit paddhatinmadhye calcinsarkhya pratidipti rangasah thet labeling kinwa europeums labeling yasarkhya goshtincha samavesh hoto, jeey yuu. yuu. 3 + sodalyavar pratidiptiman banate aanee chillatorshi bandhale jaate. bahu-well fluorometerdware kinwa flow cytometry paddhatindware pratidipti mojali jaau shakate. enzymatic-aadharit parikshan dekhil aahet jyat leased peshinchya samgrimadhye gapped sarkhya cellular enzymescha samavesh asato jeey sakriy rahatat; tyaa enzymesathi thurr puravane asha pratikriyes utprerit karoo shakate jyache utpadan prakashadvare kinwa shoshanadvare shodhale jaau shakate.
vaidyakeey anuprayog.
aine. keey. peshi arbud peshi aanee tyanchya prushthbhagavar emm. etch. see. aay. aay itar peshi nasht karnyat guntalelya asatat, jeey swayam-nasaleli peshi darshavtat. aine. keey. peshi, yazman peshishi sanvad sadhlyanantarach yazman nasalelya peshi nasht karnyasathi pratikriya denyachya tyanchya kshamatemule smrutee peshinpramanech vagatat asey disun aale aahe. aine. keey. peshi rogpratikarak shaktichya vishisht margansathi swatah vishisht naslyamule, tyancha vapar aii. dii. see. see. madhye bahutek vela pratipinde-vishisht apoptosis yantranepeksha qamee bhedbhav karnare peshi vidhvansak mhanoon keela jaato. sakriy 'ex vivo' aine. keey. peshinchi kshamata haah arbudanvaril upcharansathi swarasyapoorn vishay rahila aahe. cytokinesdware sakriyatechya suruvatichya vaidyakeey chachanyanantar kharab parinam aanee gambhir vishakt dushparinam disun aale, alikadil abhyasanni aine. keey. peshi sakriy karnyasathi interleukin prathinancha vapar karoon metastatic tumourche niyaman karnyat yash midavale aahe.
trustuzumab aanee retooksimab monoclonal pratipindanmadhil ghan arbudanvaril parinam undaranchya prayoganmadhye upcharatmak krutichi eka mahattvachi yantrana mhanoon aii. dii. see. see. samavisht karnyasathi darshavile gele aahet. klinikmadhye, eff. see. jee. aar. aay. aay. 158 vhee./eff. bahurupata heey trustuzumab upcharadarmyan aii. dii. see. see. pratisad "inn vitro" nirman karnyachya kshamatet hastakshep karate.
ekadhik myelomacha upchar daratumab (darzalex) monoclonal pratipindesah keela jaau shakato. inn vitro' sahitya aanee rugna samagrisah kelelya abhyasatoon asey soochit hote qee see. dii. see. (purak-avalambun asalelya cytotoxicity) sobat aii. dii. see. see. hii eka mahattvachi yantrana aahe.
rogpratikarak niyantranat vaparale jaanare aii. dii. see. see. heey samanyatah procariotic peshinvar vishanu-sambandhit pratijananshi bandhalelya aay. jee. jee. pratipindanmule pratipindanmule jivanu sansargapeksha vishanujanya sansargasathi adhik upayukt asate. aii. dii. see. see. bahereel vishari padarth kadhoon taknyaivaji, immunoglobulin sansarg lakshya jivanunchya utpadananna nishprabhavi karatat aanee sankramit yazman peshinna vedhatat, jyat jivanu vishari padarth thet peshi pataladvare ghatale gele aahet.
lasichya vaparat aii. dii. see. see. dekhil mahattvache aahe, kaaran pratipinde tayar karane aanee yazman sharirat samavisht kelelya pratijanancha naash haah vishanujanya aanee jivanu prathinanchya chhotya samparkat yeuun pratikarshakti nirman karnyasathi mahattvapoorn aahe. yachya udaharananmadhye vishari padarthanmadhye (aar. tii. ex.) punaravrutti lakshya lakshya lasincha samavesh aahe, jyaa haemolycines mhanoon varnan kelelya vividh prakarchya erythrocyte-lissing jivanunsathi sanrachanatmakdrushtya mahattvapoorn aahet. heey jivanu leukocytes see. dii. 18 bhagala lakshya karatat, jeey aitihasikdrushtya sanlagnata-kamatarata asalelya peshinmadhye aii. dii. see. see. varr parinam karatat asey darshavile gele aahe.

