susangatata network topologiever aadharit denoising algoridam

prasangikta network topologiever aadharit denoising algoridam (dart) haah eka unsupervised algoridam aahe joou denoising tappyanantar, januk abhivyakti matrixmadhil margasathi kriyakalap gunank andajit karato. dartmadhye, bharit sarasari vaparali jaate jithe vajane chhatani kelelya jaalyatil nodeschee degree pratibimbit karatat. denoisingchi payari deta sanchas visangat asaleli purv mahitee kadhoon takte. heey dhoran vegalya jaivik pranali kinwa sandarbhatun shikalelya purvichya pratimanavar aadharit asalelya marg kriyakalapanchya paryavekshit nasalelya andajanmadhye lakshaniy sudharana karate.
januk sanch sanwardhan vishleshan paddhatisarkhya aadhipasoon astitvat asalelya paddhati andaj lavnyacha prayatna karatat. tathapi, tyane janukanchi sanrachit yadee tayar kelee nahee. spiya (signalling pathve impact analysis) hii eka paddhat aahe jee done phenotypemadhil pathve kriyakalapanche moolyankan karnyasathi phenotype mahitee vaparte. tathapi, teey marg januk upasanch olakhat nahee jyacha vapar vaiyaktik namunyanmadhye farak karnyasathi keela jaau shakato.
corgcha vapar sambandhit januk upasanch olakhanyasathi keela jaato. hii eka paryavekshit paddhat aahe, jee swatantra deta sanch vishleshanat changli kamgiri karat nahee
jokhim moolyankan, vaidyakeey nidan aanee upcharansathi aanvik marg kriyakalap samajoon ghene mahattvache aahe. jatil janukeey mahitiche meta-vishleshan heey heey mothya mahititoon upayukt mahitee kadhane, gondhal ghalanare ghatak door karane aanee adhik vivekpurn arth pradan karane yasarkhya adchaninshi sambandhit asate. 
januk abhivyakticha adhik changla andaj denyasathi sambandhit margachi olakh thalak karnyasathi vividh drushtikon sweekarle gele aahet.
ranniti.
pratilekhan staravar niyamak januke aanee januk abhivyakti deta sanch yanchyat nashpatiche parasparsambandh pratham mojale gele. tyanantar parasparsambandh gunankamadhye machchimaranche parivartan jhaleh 
jethe see. aay. jee. haah januk i aanee jeey yanchyatil parasparsambandh gunank aahe aanee jethe γij haah chull aahe, shoonya gruhitkanusar, tyachi sarasari shoonya aahe aanee manak vichalan 1/aahe, jethe ns hii gaath namunyanchi sankhya aahe. pii-mulyachi maryada 0.0001 varr nishchit kelee gelee hotee. mahattvapoorn parasparsambandh asalelya januk jodya jaalyamadhye sambandhit manalya jaatil. 
jyaa kriyakalapanchya gunankamadhye jawalchya januke dekhil vicharat ghetali jaatat tyacha andaj lavnyasathih
sootra _ 2
jethe qee hii januk i chya shejari lokanchi sankhya aahe, zaay hii samanyikrut zed-gunank aahe aanee σi hii dwaiti chull (i.eae 1 mhanje sakriy kelyavar niyaman kelele aanee-1 mhanje niyaman kelele). hii payari sakriyatechya patalicha andaj lavnyasathi aahe, jyamadhye ess. doubleu. aii. vhee. haah kriyakalap gunank aahe. tyanantar marg sakriyatechya patalicha andaj ghenyasathi eka resheey pratigaman model lagoo kele gele. asha prakare, tij aanee pij heey tii-sankhyiki aanee pii-moolya darshavtat, tarr pii <0.05 heey mahatva darshavtat.
pramanikaran deta sanch dii madheel susangatateche moolyankan karnyasathi, kamgiriche mojmap vij darshavile jaateh
sootra _ 3
jethe ess paribhashit kele jaate
sootra _ 4
ess heey dilelya marganchya jodiche threshold function aahe.
aanee kuthe?
sootra _ 5
σij haah gunank aahe joou parasparsambandhachi disha sangato, jyamadhye viruddha andaj-1 chey moolya deuun panel keela jaeel. tij haah interpathway sahsambandhancha tii-sankhyiki aahe. 
karyapradarshan mojmap vij heey marganmadhil parasparsambandhache mahatva, parasparsambandhachi disha aanee parasparsambandhachya parimanatil vajan darshavate. 
gruhitkanusar vitaranachi tulana karnyasathi done shepatichi jodee asaleli wilcoxon chachani kelee jaate. 
fayade aanee maryadah
dart heey marg detabesesachya purv mahitivarun marg kriyakalapancha andaj lavnyat sudharit kamgiri aanee uchch achookata dete. dart chalvanyasathi aadhipasoon astitvat asaleli mahitee aanee motha databases aavashyak aahe. aahe shabdant, dartla suruvatila purv-sthapit januk abhivyakti mahitichi aavashyakta asate aanee nantar tee susangatateche moolyankan pudhe neuu shakate aanee konatyahi aprasangik mahiticha naash karoo shakate.
arj.
dart haah eka algoridam aahe joou karkarogachya genomixmadhye lagoo hoto aanee yashasviritya vaparla jaato. dart algoridam hii stun aanee fuffusachya karkarogachya januk abhivyakti deta sanchatil marg kriyakalap aanee vikshobh swakshari kriyakalapancha andaj lavnyasathi eka majboot paddhat asalyache darshavile gele aahe.
karkarogachya arbudachya nidanat imaging vaishishtye jase qee mammography (mammography hii manvi stanachya uutinche parikshan karnyasathi qamee-urja ex-reey vaparanyachi prakriya aahe) mahattvachi bhoomika bajavate. abhyasatoon asey disun aale aahe qee, stanadarshanachi vadhati ghanata asalelya mahilanna stanacha karkarog honyacha dhoka jaast asato. istrogen receptor alfa januk 1, istrogen receptor-alfa, joou istrojendware sakriy hoto, tyala sanketikrut karate. eae. ess. aar. 1 madheel bahurupata stanachya ghanatechya vegvegalya patalitil farkandware stanachya karkarogachya jokhamishi sambandhit aahet. dartney dartney signalling aanee emm. emm. dii. yanchyatil ulat parasparsambandhacha yashasvi andaj vartavala.
yacha vapar semulated aanee vastavik bahuayami karkarogachya janukeey detamadhye keela jaau shakato. heey marg sakriy karnyabaddal adhik vishvasarh andaj dete, jeey sanlagn abhyasat upayukt tharel.

