pier 1

pier 1 (liminib) heey carbon, hydrogen, auxigen aanee nitrogenne banalele sendriya sanyug aahe jeey liim keynage yaa enzymela pratibandhit karate.
2010 chya dashakat see. aine. aar. ess. aanee see. eae. aii. yaa rognivarak aanee roganu sansthene yacha shodh lavala. inn vitro' aanee pranyanvaril abhyas heey siddha karatat qee yaa renumadhye krutichi eka purnapane naveen yantrana aahe jee chemotherapy pratirodhak peshinviruddha vaparali jaau shakate.
pier 1 microtubulesla ulatya paddhatine sthir karate, actin microphilament dynamicsla avarodhit karate aanee peshinchi gatishilata "inn vitro" pratibandhit karate. hii vaishishtye keval karkarogvirodhi gunadharmach navhe tarr renula metastasis rokhanyachi kshamata dekhil pradan karatat.
varnan aanee gunadharm.
pier 1 heey pyridocarbazolechya gatashi sambandhit eka lahan renu mhanoon vargikrut kele aahe. tyacha lahan aakar tyala vishesh gunadharm detoh eka halka renu mhanoon gatishil jaivik prakriyancha abhyas karnyasathi heey eka maulyavan sadhan aahe. tyamule vaidyakeey aanee jaivik tapasat haah eka mahattvacha shodh aahe. haah eka uchch darjacha prathine tatpurata niyantrak aahe, kaaran too kahee minitant kinwa agadi sekandanmadhye limk 1 sarkhya renunshi sanvad sadhanyas saksham aahe. tyachi ulatta tyala patkan sakriy aanee swatahla rokhanyas saksham karate, jyamule renu "inn vitro" aanee "inn cellulo" donhimadhye eka vishisht avarodhak banato.
pier 1 chey varnan sadhya sanrachanesah tetracyclic renu mhanoon kele jaau shakate. tyachya kahee muldravyancha benzinchya vartulanmadhye mothya pramanavar vistar keela jaato, jyamule navvya karbanmadhye benzoloxy gut aanee carbon paach aanee akra madhye done methyl muldravyanmadhye farak hoto. carbon ekmadhye eka keaton gut aanee carbon done aanee sahaa madhye done hydrogen radicals dekhil aahet.
krutichi yantrana.
pier 1 haah liim kinejacha (visheshtah limk 1) peshi pargamya spardhatmak avarodhak aahe. nantarche heey enzyme aahe jeey aii. tii. pii. chaa vapar phosphoryletsathi karate aanee actin-depolymerising factor coffilin nishkriy karate. jevha coffilin phosphorylated asate, tevha teey actinchi gatishilata niyantrit karate. limk 1 sukshmanalikanche depolymerisation dekhil karate.
pier 1 chya upasthitit, limk 1 pratibandhit kele jaate, jyacha arth assa aahe qee coffilinche phosphorylation qamee hote, jyamule actin microfilamentschya gatishilatechya niyamanat adthala yeto aanee tyamule microfilamentschi avyavastha hote. yamule sukshmanalikanche sthirikaran dekhil hote. haah pratibandh ulat karata yenyajoga aahe.
shevati, pier 1 peshinchi gatishilata rokhate aanee actinchi gatishilata niyantrit karate aanee sukshmanalikanna sthir karate. heey gunadharm karkarogvirodhi upcharanmadhye vaparale jaau shakatat.
vaidyakeey anuprayog.
karkarogachya metastasismadhye asamanya peshinche jalad aanee aniyantrit vibhajan hote. mitosismadhye sukshmanalikanchi mahattvachi bhoomika asateh teey mytotic spindle assembly tayar karatat, jyamule gunasutra vegale karane aanee peshi vibhajan shakya hote. tyanchya sthirikaranamule peshinche punarutpadan karnyat kinwa tyanchya apoptosismadhye asamarthata yete. mhanunach microtubule lakshya karnare ghatak, aajkal, shaktishali karkarogvirodhi aushadhe aahet. tubulin heey aata karkarogachya sarvat pramanit lakshyanpaiki eka qaa manale jaate heey dekhil teey spasht karate.
tathapi, yaa karkarogvirodhi aushadhanchya kahee maryada, pramukhyane myelospression aanee neurotoxicity yaa dushparinamanmule aahet. parantu mukhya gairsoy ashee aahe qee anek karkarog yaa aushadhanna pratirodhak asatat kinwa banatat. adhik prabhavi aanee qamee vishari karkarogvirodhi aushadhanchya vikasasathi anek dhorane prastavit kelee gelee aahet. tyapaiki eka mhanje sukshmanalikanche sthirikaran prerit karoo shakanare renu vaparane aanee pier 1 tyapaiki eka aahe.
karkarogavaril upcharanmadhye pier 1 chaa vapar keela jaau shakato, kaaran tyache mukhya lakshya enzyme (liim keynage) heey microtubule aanee actin dynamicsche niyamak aahe. shivay, asey disun aale aahe qee pier 1 karkarogachya peshinchya reshansathi vishari aahe, agadi jeey paramparik microtubule lakshyikaran agentsna pratirodhak aahet.
shivay, pier 1 chee visharita undaranmadhye abhyasali gelee aahe, heey moolyankan karnyasathi qee too kharokhar chemotherapeutic agent mhanoon kaam karoo shakato qee nahee. parinam heey darshavtat qee, konatyahi visharipanashivay, zenographted tumerviruddha undaranche sampoorn astitva disun aale aahe, kaaran vajan qamee jhalyache disun aale nahee. tyamule, assa nishkarsh kadhala gela aahe qee pier 1 madhye, pranyanni changlya prakare sahan kelelya matret gaath vaadh honyapasoon rokhanari changli upcharatmak parinamkarakta aahe.
mageel mudde lakshat gheuun, aushadh pratirodhak arbudanmadhye manak chemotherapy vyatirikt kinwa paryay mhanoon pier 1 vaparla jaau shakato.

