cossegrigation

cossegrigation mhanje ekach gunasutrachya jawal asalelya done kinwa adhik janukanche pudhchya pidhimadhye sankraman. tyanchya jawalik yacha arth teey anuvanshikdrushtya jodalele aahet. heey konatyahi sankhyechya sthananmadhil parasparsanvadachya andaj sambhavyateche pratinidhitva dekhil karoo shakate. 
lakshya janukache (lokee) vishisht bhag aanee anoo profilecha (aine. pii. ess.) gut vaparoon parasparsanvadachi sambhavyata nishchit kelee jaate. ujavikadil chitra kendrakatoon eka tukada (aine. pii.) kassa ghetala jaato aanee aine. pii. madhye lokee kassa shodhala jaato yabaddal drushya sahayya pradan karate. itar ganiteey pratimanmadhye vaparale jaanare cossegrigation (slies aanee samanyikrut linkage asantulan) genome architecture mapping (gamm) chee eka lahan prakriya mhanoon 3-dii visualization sadar karnyat madat karate. heey anuvad janukeey ghanata aanee trijya sthitee nirdharit karnyas madat karatat.
itihas.
genome architecture mappingmadhil (gamm) cossegrigation hii janukeey khidkyanchi sankuchan aanee sanlagnata olakhanyasathi vaparali jaanari aanakhi eka prakriya aahe. 2017 salchya eka abhyasat, gamchya mothya prakriyet sastan pranyanchya kendrakanmadhil genomeche aayojan karnyasathi januk-abhivyakti-vishisht sampark samajoon ghenyasathi cossegrigation vapar karnyat aala. abhyasachya nikalanni jatil jeey sanrachana tayar kelya, jyat chromatin samparkanchya vishisht pradeshankhali parasparsanvad darshavila gela aanee heey siddha kele qee genome jivshastradnyanchya kaushalya sanchamadhye game heey eka upayukt sadhan aahe, jeey jeey chromatin sanrachana, peshinche prakar aanee maulyavan manvi namune bareek vichhedan karanyachi kshamata vadhavate. 2021 madheel eka abhyasat, jevha lamb januke atyant vyakt kelee jaatat aanee/kinwa uchch chromatin sulabhata asate tevha tyanche vyapak 'vitalane' aadhalale. neuron upprakaranpaiki sarvat vishisht samparkanmadhye vyasan aanee synaptic plasticitisarkhya vishesh prakriyanshi sambandhit januke asatat, jee upalabdh chromatin pradeshanmadhye neuronal transcription ghatkansathi anumanit bandhan sthalanna aashray detat."yaa donhi abhyasanmadhye undarancha vapar manavanshi tyanchya sharirik, sharirik aanee anuvanshik samanatemule namuna mhanoon keela gela.
cossegrigation vapar karnare kahee sarvat june dnyat abhyas 1980 chya dashakachya suruvatiche aahet. yaa kalat, chloroplast dnahe adviteey anukram aahet qaa heey pahanyasathi shastradnya vanaspatijanya jivanvar prayog karat hote. yaa prayogachi prakriya mhanje, pratyek pidhitil chloroplast janukacha magova gheuun, nucleoidmadhil janukanchi samoohani karoon, vegale kelelya ekkanchi sankhya qamee karane. haah abhyas pranishastra vibhagatil duke vidyapithat karnyat aala hota, jithe carren pii. vanvinkle-swiftney vanshavali aakrutincha vapar karoon, hii vaishishtye aanee kram palkakadoon mulamadhye kase hastantarit kele gele heey dakhavale.
vapar.
anek ghatakanchya parasparsanvadacha vichar keela jaat asalelya prakaranansathi cossegrigation sarvat yogya aahe. heey vividh ghatak kase jodalele aahet heey darshavu shakate aanee tyanche parasparsanvad aanee sambandh thalakpane dakhavu shakate. udaharanarth, jarr ekhada anuvanshik vikar ekhadya vishisht janukashi sambandhit asalyache olakhale gele, parantu jevha teey januka asate tevha nehmich upasthit nasate, tarr cossegrigation vishleshan itar januke olakhanyas madat karoo shakate jee sanshayit janukashi samanyapeksha jaast vela sanvad sadhatat. yamule sanshodhakanna anuvanshik vikar prakat prakat janukanche sanyojan shodhanyas pravrutt karata yeil. karkarog sanshodhanasarkhya vaidyakeey kshetrat cossegrigation sakriyapane vapar keela jaat aahe. karkarog vikasit hoto asha prakarananmadhye heey janukanmadhil sarvat majboot sambandh adhorekhit karoo shakate. heey upayukt aahe kaaran karkarogas karanibhoot asanari ekahi janukat sahasa nasate. tyaeivaji, karkarog haah anek janukanchya sanyoganmule houu shakato. cossegrigation heey sanyojan tayar karoo karoo janukanmadhil sambandh darshavinyas madat karate.
cossegrigation vaparanyachi udaharane.
cossegrigation vapar karoon kelelya anuprayogache eka udaharan mhanje done sthananmadhil samanyikrut sambandh asamatol (aine. ell.) shodhane. shodhane dataset (pankti = janukeey vindo slies, stambh = nuclear profile (aine. pii.)) dilelya vindomadhye aine. pii. astitvat asalyas kinwa anyatha "0" asalyas eka "1" pradarshit kele gele. yaa mahitivarun, aine. ell. heey moolbhut sootra _ 1 asantulan aanee tyache siddhantit kamal (sootra _ 2) vaparoon shodhale jaau shakate. lokee (genomic vindo) sootra _ 3 aanee sootra _ 4 madhye upasthit asalelya aine. pii. ess. chey praman, nantar sootra _ 5, sootra _ 6 aanee sootra _ 7 aanee saha-vibhajan jeey sootra _ 8 aahe teey shodhanyasathi vaparale jaate. done lokee darmyan aine. ell. sapadlyanantar, nantar teey dusarya detasetmadhye drushyikaranachya drushtine thewale gele aanee nantar lokee kitee ekmekanshi jodaleli aahe heey nirdharit karnyasathi vishleshan kele gele.
dilelya deta aanee parinamanchi ganana aanee drushyikaran karnyasathi aanee aine. ell. shodhanyasathi pythoncha vapar karoon heey udaharan karyanvit kele gele. aine. ell. chaa vapar karoon khidakya "samudayanmadhye" thevanyasathi pudhil vishleshan kele jaau shakate. heey dakhavanyasathi ujavikadil aalekh, khidakichya aine. ell. ess. chee sarasari sarasari sarvoch kendriyatesaha eka khidakicha samuday darshavel.
sootra.
ujavikadil aakrutitil chhadm-kodmadhye disalyapramane heey sootra sahajpane kodmadhye program kele jaau shakate. varr varnan kelelya udaharanache samadhan karnyasathi code lihila gela hota.
fayade.
anoo profilecha motha dataset dilyas, tyachya sopya ganiteey sutranmule cossegrigation sahajpane scalable aahe. pradan kelela deta sanch jitka motha asel, titaki khaleel samikarane adhik achook asateel. khaleel chhayachitrat darshavilyapramane, samikaranat jodalya kelya mahitiche praman mool samikaranat fakt resheey veleche samayojan karate. 
sudaivane, teey keval detasetchya aakarache mojmap karnyas saksham nahee tarr parasparsanvadachi sambhavyata nirdharit karnyasathi aavashyak asalelya fokasache anek sthan ghenyas saksham aahe. pratyek sthan jodalyane samikaranat ekach ganana jodali gelee tarr resheey vel jatilata haah parinam aahe. khalee dilele chitra lokichya pramanamule shodh varanvartechya samikaranavar kassa parinam hoto heey darshavate.
shevati, parinami yenare sankhyatmak moolya, trijya sthitee, sankshepan aanee sarvat prabhavshali sampark yasah anek nishkarsh kadhanyas madat karoo shakate.
maryada.
prabhavi cossegrigation vishleshan heey mukhyatve majboot aadhar denara dataset asanyavar avalambun asate kaaran agadi lahan truti dekhil kosegrigeshandware vadhavalya jaau shakatat. samagrichi sampoorn samaj aavashyak aahe kaaran cossegrigation keval datapoints darmyanche sambandh pradan karate. tyaa jodanyancha arth kinwa paddhatidvare keela jaane aavashyak aahe. udaharanarth, locus cossegrigation samanyatah ekmekanshi sanvad sanvad janukancha gunank deu shakate, parantu teey sambandh kitihi majboot asale taree, parimanatmak cossegrigation parinam ektar parasparsambandhit, parasparvirodhi kinwa swatantra sambandhanna samarthan denare vatoo shakatat. yachee jaaniv asane aanee vishleshanachya dusarya prakarasah cossegrigation vishleshanacha pathpurava karane mahatvache aahe, jase qee sanyugma prabhav durust karnyasathi samanyikrut jodani asantulan cossegrigation detachya shodh varanvartemadhye nagany badal houu shakato.
udaharanarth, karkarogachya eka sadhya swarupachi kalpana qaraa, joou thodya pramanat janukandware trigg keela jaato. yethe aapan eka sanshayit januk aanee itar teen janukanchi tapasani karat aahot, jyaa prakriyanmadhye sameel asalyacha sanshay aahe. haah takta 10 lokancha eka kalpanik deta sanch aanee tyanchi karkarogachi sthitee tasech tyanchyakade swarasya asaleli chaar januke aahet qaa heey darshavito. aalekh pahata, sanshayit januk aanee januk aaa yanchyat spasht sambandh aahe. sanshayit januk aanee januk see yanchyat qamee spasht parasparkriya dekhil aahe jee keval januk bii anupasthit asatana hote. heey purnapane shakya aahe qee saha-vibhajanala teey naate nishchit karnyat katheen vel yeil. buub januk samanyatah aaa janukasah asate aanee tyaa sanyojanamule karkarog hoto. shekado kinwa hajaro janukanchi tapasani kelya kelya vastavik mahitee sanchamadhye, jevha pratyakshat teey karkarogas hatbhar lavat nahee aanee pratyakshat tyala rokhu shakat nahee, tevha buub januk karkarogas hatbhar lavte assa nishkarsh konee chukun kadhu shakato.
yaa tantrachi aanakhi eka maryada ashee aahe qee anek mapping sadhane keval janukanmadhil vishisht sharirik parasparsanvadach navhe tarr yadruchchik sampark dekhil mojatat, nantarche qamee resheey janukeey antar asalelya janukanmadhye adhik samanya asalyane yamule saha-vibhajan guna vadhatat. gemane hii samasya sodavanyas madat kelee aahe kaaran gemmadhye genomic vindo shodhane heey itar pradeshanshi pradeshanshi konatyahi parasparsanvadapasun swatantra aahe. yamule apekshit parasparsanvadache moolya mojata yete aanee yadruchchik jodanyancha aavaj filter karnyasathi saha-vibhajan parinamansah heey ekatra karane heey eka swachchh parinam pradan karel.
drushye.
matricks.
matricks hii sankhyanchi (nondi) aayatakruti sanrachit rachana aahe jithe pramanak ganitachya karyancha vapar karoon nondinchi berries, vaja, gunakar aanee vibhagani kelee jaau shakate. saha-vibhajanachya babatit, aalekh siddhant haah nodeschya jaalyavaril chull eka dharasah kinwa kinwa chalasah shirobindu samayik karato qee nahee heey pahanyasathi vaparla jaato. aalekh siddhant haah jodidar sambandhancha vapar karoon vastooncha ganiteey abhyas aahe joou jodalya gelelya nodesdware darshavila jaato jyala shirobindu mhanatat jeey kadanni itar nodeshey jodalele asatat.
vareel pratima cossegrigation matrixpasoon sanlagnata matrixmadhye honare rupantaran darshavate, genome architecture mappingmadhil matrixcha eka vapar aahe, jithe shastradnya dii. aine. aii. pradesh, genome aanee/kinwa elilmadhil collocalisation shodhanyasathi cryosectioning vapar karat aahet. tyaa udaharanamadhye, genomemadhil vishisht khidkyanmadhil antarachya drushtine detachya ekmekanshi asalelya jodaniche varnan karnyasathi cossegrigation vapar keela jaat aahe. vareel sootra vaparoon cossegrigation matrixmadhil moolye aadhalali. khidkyanchi tulana kartana, sootra sambandhit khidkyanmadhil anoo profileche chhedanbindu shodhanyacha prayatna karate. genomic khidakya nodes asateel aanee sanlagnata aalekh haah pratyek nodala nodala kadache matricks chitran aahe.
ushnateche nakashe.
ushnatecha nakasha heey matrixche drushya pratinidhitva aahe jeey dvi-aayami pramanavar bhinn ghatana darshavu shakate. ushnatechya nakashanmadhye, mahititoon dilelya mulyanvar aanee pramanavar aadharit ranganchya tivratechi shreni asate. kodinganusar, plotly sarkhya granthalayancha vapar karoon ushnateche nakashe tayar kele jaau shakatat.paythanmadhye vyakt qaraa. saha-vibhajan vaparoon, 2 kinwa adhik chalanmadhil samanatanchi kalpana karnyasathi 1 kinwa 0 chee moolye asalelya matrixchi kalpana karnyasathi ushnatechya nakashacha vapar keela jaato. "ushnateche nakashe vaparnyacha prathamik fayda mhanje teey anyatha nistej kinwa abhedya mahitee samajanyayogya banavtat. anek lock ushnateche nakashe antardnyanane samajoon ghetat, heey sanganyachi garajahi nasate qee teey ubdar rung parasparsanvadache ghanata kendra darshavtat."
maryada vibhagat, samanyikrut aanee samanyikrut nasalelya mahitimadhil farak darshavinare done ushnateche nakashe (sahaj pahanyasathi khalee dekhil thewale aahet) darshavile aahet. aalekhatil farak darshavalyane sanshodhkala rung pravanatechya tivratevar tasech deta pointschya samoohavar aadharit vividh namune olakhanyas madat hoil. varr pahilyanusar cossegrigation parinamanchi vegvegali rupe asoo shakatat aanee ushnatechya nakashanmadhye tyanchi kalpana kelyane sanshodhakanna matrixpramanech konate genome jodalele aahet heey samajoon ghenyas madat houu shakate.
garam nakashe tayar karnyasathi eka maryada ashee aahe qee kahee software aalekhavar vishisht bindu shodhanyachi parvanagi dett naheet, visheshtah jarr anek chull asateel tarr. plotlysarkhi coding library aahet.asey vyakt qaraa jeey parasparsanvadi ushnateche nakashe tayar karoo shakate jethe programmer aalekhavar nirdisht bindunvar firu shakato aanee achook aashrit chalanche moolya vachoo shakato. aanakhi eka maryada mhanje ushnateche nakashe vastavik-velecha deta darshavat naheet. ushnateche nakashe kalantarane mahitee ektrit karoon kaam karat asalyane, teey aadhipasunach upasthit asalelya adhik prabhavi namunyanchya tulanet vartanat alikadil badal darshavat nahee.

