
seudohypoaldosteronisterone

seudohypoaldosteronisterone (phaa) hii eka ashee sthitee aahe jee hypoaldosteronismchi nakkal karate. tathapi, hii sthitee aldosteronla "pratisad" naan midalyamule aahe aanee pratisad pratibandh naan midalyamule aldosteronchi patali pratyakshat vadhate.
sadarikaran.
uchch raktadab, hyperclemia, chayapachay aamlata aanee mutrapindache samanya karya heey chikitsalayinadrushtya phaa2 chey vaishishtya aahe.
yantrana.
phai2 laa kautumbik hyperclemic hypertension kinwa gorden syndrome asehi mhanatat. antarnihit anuvanshik doshamule mutrapindatil durastha nalikanmadhye soodiyam chlorideche punarshoshan vadhate, jyamule aakarman vadhate, uchch raktadab hoto aanee reninchi patali qamee hote. phaa2 madhye aadhalanara hyperclemia heey cortical sangrahit nalikanmadhye sodiyamche qamee vitaran karnyache karya prastavit kele aahe (potassium utsarjanamadhye mutrapindachya bahya medyukt potassium vahini romakdware madhyasthi kelee jaate jyamadhye sodiyamche punarshoshan bhoomika bajavate). vaikalpikaritya, wnke4 utparivartan jyamule naa-cl saha-vahakache karya vadhate tyamule hyperclemiachya parinami rome kriyakalap rokhata yetat. jyaa phaa1 madhye aldosteron pratirodh asato tyachya ulat, phaa2 madhye aakarmanachya vistaramule aldosteronchi patali tulanene qamee hote.
upchar.
phaa1chya gambhir swarupanchya upcharansathi tulanene mothya pramanat soodiyam chloridechi aavashyakta asate.
yaa paristhitinmadhye hyperclemia dekhil samavisht asato.
yaulat, phaa2 (gorden syndrome) sathee mithache nirbandh aanee soodiyam chlorideche punarshoshan rokhanyasathi aanee raktadab aanee seeram potassium samanya karnyasathi thyzide mutravardhak padarthancha vapar aavashyak aahe.
itihas.
yaa lakshansamuchchayache varnan pahilyanda 1958 madhye gaal aanee peree yanni kele hote.
nantar balrog endocrinologist aaron hanucoglu yanni nondavale qee vegvegalya varshanchya namunyansah fache done swatantra prakar aaheth autosomal prabal varshasah mutrapindache eka swaroop jeey pramukhyane mutrapindatun mithachi haanee darshavate aanee autosomal recessive swarupasah eka bahu-pranali swaroop jeey mootrapind, fuffus aanee gham aanee laale granthitoon mithachi haanee darshavate.
aldosteronla pratisad denyachya aanuvanshik abhavamule kiman done shakyata asoo shakatatah 1. mineralocorticoid receptormadhye utparivartan jeey aldosteronla bandhate kinwa 2. aldosterondware niyantrit kelelya janukatil utparivartan. fachya gambhir swarupachya rugnanvaril jodanichya vishleshanane mineralocorticoid receptor januk kshetrashi rogacha sambandh asanyachi shakyata vagalali. nantar, fache gambhir swaroop anukrame α, β aanee γ yaa upakala soodiyam vahini upaghatkansathichya ess. see. aine. aine. 1aii, ess. see. aine. aine. 1bii aanee ess. see. aine. aine. 1jee yaa janukanmadhil utparivartananmule asalyache aadhalun aale.
ess. see. aine. aine. 1aii. janukatil eka thambanare utparivartan heey stree vandhyatvashi sambandhit asalyache disun aale aahe.