
aar. aar. tii. 1

mitochondrial roow jee. tii. paces 1 (miro 1) heey eka enzyme aahe jeey manavanmadhye gunasutra 17 vareel "aar. aar. tii. 1" janukadware encode kele jaate. myro prathin isophorm mhanoon, prathine mitochondria motor/adaptor complexeshy jodoon mitochondrial vahtook sulabh karatat. mitochondrial vahatukitil tyachya pramukh bhoomikedware, aar. aar. tii. 1 haah mitochondrial homeostasis aanee apoptosis, tasech parkinson rog (pii. dii.) aanee karkarogamadhye sameel aahe.
rachana.
sastan pranyanmadhye, rott 1 heey done myro samarupanpaiki eka aahe. donhi samarupanmadhye done jee. tii. pii.-bandhan kshetranna jodana done eae. eff.-hand motifschee rachana asate aanee eka see-terminal transmembrane kshetra jeey prathinanna bahya mitochondrial patlala (oo. emm. emm.) jodate. eae. eff.-hand motif heey adaptor prathine milton aanee kinesine judd sakhalisathi bandhan sthal mhanoon kaam karatat. hii kshetre calcium aayanana dekhil bandhu shakatat aanee bandhanimule sanrachanatmak badal hoto jyamule mitochondrial prushthbhag kinesinpasoon vegala hoto.
karya.
aar. aar. tii. 1 haah aar. oo. jee. tii. paces kutumbatil eka sadasya aahe aanee protein mirochya done samarupanpaiki eka aaheh aar. aar. tii. 1 (miro 1) aanee aar. aar. tii. 2 (miro 2). roow jee. tii. paces kutumbatil urvarit lokanchya tulanet, tyanchya bhinn niyamnamule, miro samarupata hii asamanya manali jaate. shivay, myro isophorm keval mitochondriamadhye vyakt kele jaatat.
mitochondrial motor/adaptor complexes tayar karnyasathi miro haah milton (track 1/2) aanee motor prathine kinesin aanee dyninshee jodala jaato. myro heey sankul mitochondrianmadhye pathvanyasathi karya karate tarr complexes peshinmadhil microtubulesdwar mitochondrianchi vahtook karate. jaree mirocha pramukhyane neuronsmadhye abhyas keela gela asala, taree lymphocytesmadhil mitochondria sooj jhalelya endotheliakade nenyat sahbhagi honyasathi prathine dekhil aadhalali aahet.
motor/adaptor complexes calcium aayanchya patalidvare niyantrit kele jaate. uchch sandratemadhye, calcium aayan mitochondrial vahtook mirola bandhun rokhatat, jyamule complexes organelpasoon vegale hote. dendritesmadhil glutamate receptorsche sakriyakaran, akshatantunmadhil krutee kshamata aanee neuromodulator yasarkhe sharirik ghatak calcium aayanchi patali vadhavu shakatat heey lakshat gheta, hii niyamak yantrana calcium aayan buffering aanee sakriy niryat pradan karnyasathi asha bhagat mitochondria rakhanyasathi aanee asha prakare, homeostasis rakhanyasathi kaam karate.
yavyatirikt, mitofucine sanyogane mitochondrial fusion aanee mitophagyche niyaman myro karate. eka pratimananusar, kharab jhalele mitochondria heey nirogi mitochondriapasoon myro aanee mitofucine hasamule vegale kele jaatat. myro degradationmule tyanchi halchal thambate tarr mitofucin degradation tyanna nirogi mitochondriashy misalanyapasun rokhate, asha prakare autofagosomsdware tyanchi safsafai sulabh hote.
jaree achook yantrana spasht karane baakee asale taree, aar. aar. tii. 1 heey caspage-aashrit apoptosisla protsahan denyat guntalele aahe.
vaidyakeey mahatva.
abhyas asey darshavtat qee myro haah pidimadhye samavisht asoo shakato. neuronsmadhye, miro pii. dii. madhye samavisht asalelya done pramukh prathinanshi sanvad sadhato, gulabi 1 aanee parkin. mitochondria vidhruvikaranantar, ess156saha anek thikani gulabi 1 phosphorylates miro aanee parkin sarvavyapi miro, protesomal ksharanasathi lakshya karate. miroche vighatan nantar mitochondrial vahtook thambavate.
jaree roow jee. tii. paces kutumb karkarogachya pragatishi jawalun sambandhit asale, taree asamanya myro prathinanshi assa sambandh darshavinare kahee abhyas aahet. tathapi, mitochondrial homeostasis aanee apoptosischya niyamanadvare tumour suppressor mhanoon aar. aar. tii. 1 haah swadupindachya karkarogamadhye samavisht keela gela aahe. asha prakare, heey prathin karkarogavaril upcharansathi eka upcharatmak lakshya mhanoon kaam karoo shakate.
jivanche pratikruti.
aar. aar. tii. 1 karyachya abhyasat pratikruti jivancha vapar keela gela aahe. rott1tm1a (eucomm) wtsi' navachi sashart baad ferichi maus line, aantarrashtriy baad ferichya mausachya sangh karyakramacha bhag mhanoon tayar karnyat aalee hotee-rus asalelya shastradnyanna rogache prani model tayar karnyasathi aanee vitarit karnyasathi eka uchch-utpadan utparivartan prakalp.
hatavanyache parinam nirdharit karnyasathi narr aanee maadee pranyanna pramanit phenotypic screen dilee gelee. utparivarti undaranvar 26 chachanya karnyat aalya aanee eka lakshaniy vikrutee disun aalih dudh sodanyaparyant konatehi samaroop utparivartak tikale naheet. urvarit chachanya vishamjaivik utparivartit praudh undaranvar karnyat aalya aanee pudhe konatihi vikrutee aadhalali nahee.
parasparsanvad.
rhot1 saha sanvad sadhatana dakhavale gele aaheh