thiomide

thiomide (kvachitach, thionomide, parantu thioreleans mhanoon dekhil olakhala jaato) haah samanya sanrachanesah eka karyatmak gut aahe, jithe konatehi gut (samanyatah organyl gut kinwa hydrogen) asatat. teey amideshy samaan aahet parantu teey see-aine bandhasah adhik bahuvidh bandh varn pradarshit karatat, parinami eka motha firki adthala nirman hoto. sarvat prasiddha thyomidespacky eka mhanje thioacetamide, jeey sulphide aayancha srot mhanoon vaparale jaate aanee heterocyclic rasayanshastratil eka aadharstambh aahe.
thiomides kinwa anty-thyroid aushadhe dekhil aushadhancha eka varg aahet jyaa thyrotoxicosis niyantrit karnyasathi vaparlya jaatat.
rachana aanee rachana.
thiomides samanyatah phosphorus pentasulfidesarkhya phosphorus sulphides amideswar upchar karoon tayar kele jaatat, hii pratikriya 1870 chya dashakat pahilyanda varnan kelee gelee hotee. paryayi marganmadhye lausenchya abhikarmakacha vapar kinwa hydrogen sulphides nitrilechi pratikriya yancha samavesh hotoh
wilgerodt-kindler pratikriya benzyltheomide dekhil pradan karate.
thiomidescha see (aar) (aine) (ess) gabha samtol aahe. pratinidhi mhanoon thioacetamidecha vaparah see-ess, see-aine aanee see-see antar anukrame 1.68,1.31 aanee 1.50 aahe. qamee see-ess aanee see-aine antar heey anek bandh darshavtat.
jaivarsayanshastra aanee aushadhanmadhye thiomides.
thiomides haah dekhil aushadhancha eka varg aahe joou thyrotoxicosis niyantrit karnyasathi vaparla jaato. 
thiomides peptidesmadhye amide bandhasathi isosteres mhanoon samavisht kele gele aahet. peptidemadhil badal heey mool peptideche pratirup aahet, jeey rachana-kriyakalap sambandh (saar) ughad karoo shakatat. peptidesche pratirup heey maukhik jaivupalabdhatet sudharana karoon aushadh mhanoon dekhil vaparale jaau shakatat. 
thiomides thyroidmadhil thyroid peroxidase yaa enzymela pratibandhit karatat, triodothyronine triodothyronine aanee thyroxin thyroxin chey sanshleshan qamee karatat, jyamule colloidmadhun iodotyrosins grahan rokhate. teey paridhiy samprerkatun iodeenche prakashan dekhil rokhatat. samprerak qamee hone hii qamee sanshleshanamule hote, jee eka santh prakriya aahe, tyamule jastit jaast parinam keval eka mahinyanantarch hotat.
thiomides garbhasth granthichya adthalyat pravesh karoo shakatat, tyamule garbhadharanedarmyan vapartana savadhgiri balganyacha sallah deela jaato. daha takke rugna tvachecha udrek (jase qee mccules aanee papules), artikeriya, dermatities, taap aanee arthralgiachi nond karatat; serve rugnanpaiki 0.03% madhye agranulocytosis vikasit hoto, applastic anaemia dekhil eka durmil pratikool parinam aahe.
thiomide gatachya sadasyanmadhye methimazole, carbimazole ('inn vivo' chey methimazolmadhye rupantar) aanee propyltheoracyl yancha samavesh hoto.

