mrutyu receptor 3

death receptor 3 (dii. aar. 3), jyala tumour necrosis factor receptor super family member 25 (tii. aine. eff. aar. ess. eff. 25) asehi mhanatat, haah tumour necrosis factor receptor super familicha peshi prushthbhag receptor aahe joou apoptotic signalling aanee bhinnatemadhye madhyasthi karato. tii. aine. eff. ess. eff. legand haah tyacha ekmev dnyat tii. aine. eff. ess. eff. legand aahe, joou tii. aine. eff. sarkhe prathine 1aii (tii. ell. 1aii) aahe.
karya.
yaa janukadware encode kelele prathine heey tii. aine. eff.-receptor super familyche sadasya aahet. haah receptor sakriy aanee pratijan-anubhavi tii lymphocytesdware pradhanyane vyakt keela jaato. tii. aine. eff. aar. ess. eff. 25 heey uttejana positive regulatory tii lymphocytesdware dekhil atyant vyakt kele jaate. tii. aine. eff. aar. ess. eff. 25 heey tii. ell. 1 aii. (tii. aine. eff. ess. eff. 15) mhanoon olakhalya olakhalya ekvivahit legandware sakriy kele jaate, jeey toll-sarkhya receptor kinwa eff. see. receptor sakriyatenantar pratijan sadar lakshya peshi aanee kahee endothelial peshinmadhye vegane niyantrit kele jaate. heey receptor aine. eff.-kappa bii kriyakalap uttejit karnyasathi kinwa caspage sakriyakaran uttejit karnyasathi aanee peshi apoptosis niyantrit karnyasathi phaid adaptor renudware donhisathi sanket denare darshavile gele aahe.
yaa januk encodingchya bhinn isophormsche anek paryayi splies transcript prakar nondavale gele aahet, jyapaiki bahutek sambhavyapane stravalele renu aahet. buub aanee tii peshinmadhye yaa janukachya paryayi vibhajanas tii-peshi sakriyakaranavar kramadeshit badalacha samna karava lagato, jeey pramukhyane purn lambiche, puttle baddh samaroop tayar karate aanee tii-peshi sakriyakaranadvare prerit lymphocyte prasar niyantrit karnyat sameel asalyache manale jaate. visheshtah, tii. aine. eff. aar. ess. eff. 25 chey sakriyakaran heey tii. seela receptorchya aadhichya sahbhagavar avalambun asate. tii. ell. 1aii. laa bandhalyanantar, tii. aine. eff. aar. ess. eff. 25 sanketamule tii peshinchi aay. ell.-2 receptordware antarjansheel aay. aay sanvedansheelata vadhate aanee tii peshincha prasar vadhato. receptorchi sakriyata tii seela receptorvar avalambun asalyane, vivomadhye tnfrsf 25 chee kriya tyaa tii peshinsathi vishisht aahe jyanna cognet pratijancha samna karava lagat aahe. vishrantichya velee aanee antarnihit svayampratiraksha nasalelya vyaktinsathi, cognated pratijancha niyamitpane samna lakshya bahutek tii peshi foxpy 3 + niyamak tii peshi asatat. itar konatyahi bahya sanketanchya anupasthitit tii. aine. eff. aar. ess. eff. 25 chee uttejana, uttejana + niyamak tii peshincha tyanchya serve see. dii. 4 + tii peshinchya 8-10% pasoon serve see. dii. 4 + tii peshinchya 35-40% paryant 5 divasanchya aat sakhol aanee atyant vishisht prasar uttejit karate.
upchar.
tii. aine. eff. aar. ess. eff. 25 chey upcharatmak agonist tregg vistarala uttejan denyasathi vaparale jaau shakatat, jeey damaa, allogenic ghan avyav pratyaropan aanee aucular keratayatisachya prayogik modelmadhil jaljal qamee karoo shakatat. tyachpramane, tii. aine. eff. aar. ess. eff. 25 sakriyakaran heey pratijanavar avalambun asalyamule, swayampratijanasaha kinwa lus pratijanasah tii. aine. eff. aar. ess. eff. 25 chey kharch anukaran anukrame rogpratikarak shakti vadhavanyas kinwa lus-uttejit pratikarshakti vadhavanyas karanibhoot tharoo shakate. tyamule tii. aine. eff. aar. ess. eff. 25 uttejana hii tii. peshi madhyasthi rogpratikarak shaktisathi atyant vishisht aahe, jyacha vapar tatpuratya sandarbhanusar aanee paradeshi viruddha swayam pratijan upalabdhatechya gunavattenusar jaljal vadhavanyasathi kinwa qamee karnyasathi keela jaau shakato. manavanmadhye tii. aine. eff. aar. ess. eff. 25 chya uttejanamule see. tii. ell. aii.-4 aanee pii. dii.-1 sarkhya renunna lakshya lakshya sahabhajak receptor nakabandisarkhe samaan, parantu adhik niyantrit parinam houu shakatat.

