dextromethorphane manoranjak vapar

anek pratyaksh khokala khokala sardichya aushadhanmadhye aadhalanara dextromethorphan kinwa dii. ex. emm. haah eka samanya sakriy ghatak, tyachya vighatankari prabhavansathi eka manoranjak aushadh aanee enthiogen mhanoon vaparla jaato. vaidyakiyadrushtya shifaras kelelya matranvar yache jawaljawal konatehi manoskriy parinam hott naheet. tathapi, khokala dadapun taknyasathi upcharatmak manalya manalya matranpeksha jaast pramanat dilya gelelya dosemadhye dextromethorphane shaktishali vighatankari gunadharm asatat. dii. ex. emm. chya manoranjak vaparala kadhikadhi apshabd swarupat 'robo-tripping' asey sambodhale jaate, jyacha upsarg robitucin brand navavarun aala aahe, kinwa 'tripple see. ess.', joou 'corrisidine' brandpasoon aala aahe, jyachya golya 'corrisidine khokala aanee sardi' sathee 'see. see. + see.' neey chhapalya jaatat. tathapi, chlorpheneramine upasthitimule manoranjanatmak matret vaparlyas haah brand atirikt dhoka nirman karato.
pratyaksh formulationmadhye, vedna qamee karnyasathi dii. ex. emm. laa anekada acetaminophen (paracetamol, aii. pii. aii. pii.) saha jodale jaate; tathapi, dii. ex. emm. chey vighatankari parinam sadhya karnyasathi, aii. pii. aii. pii. chaa 4000 mii. gra. chaa kamal dainandin upcharatmak doses anekada olandla jaato, jyamule yakrut sambhavya tivra kinwa junat nikami hote, jyamule dii. ex. emm. aanee aii. pii. aii. pii. donhi sambhavya pranghatak asalelya utpadanancha gairavapar aanee tyanantarchi sahishnuta hote.
1995 madhye pratham prakashit jhalelya 'daad dii. ex. emm. eff. aii. kyu.' yaa shirshakachya eka online nibandhat dextromethorphane manoranjanatmak vaparachya kshamateche varnan kele gele aanee tyachya parinamanche tathakathit patharanmadhye vargikaran kele gele.
tyachya manoranjanatmak vaparamule, americetil anek kirkol vikretyanni dextromethorphan asaleli utpadane counterchya mage halavali aahet jenekarun ekhadyane pharmacistla tee swikaranyas kinwa 18 varshe (newyork aanee alabamamadhye 19, misisipimadhye 21) kinwa tyahoon adhik vayachi asane aavashyak aahe. kahee kirkol vikrete dextromethorphan asaleli utpadane kharedi kartana durupyogachya sambhavyatebaddal mudrit shifarasi dekhil detat.
vargikaran.
uchch matret, dextromethorphane vargikaran ketamine aanee fencyclidine (pii. see. pii.) yaa niyantrit padarthanpramanech, eka vighatit samanya bhool aanee matibhram mhanoon kele jaate. tyaa aushadhanpramanech, dextromethorphan haah eka aine. emm. dii. aii. receptor virodhi aahe. heey samanyatah sharirik avalambitva-prerit padarthanche vaishishtyapurn lakshan darshavat nahee, parantu mansik avalambitva aanee sharirik avalambitva yaa donhichi prakarane purvi nondavali gelee aahet, jaree sharirik avalambitva sahasa keval mothya durupyogachya prakarananmadhye disun yete. dextromethorphane nivadak serotonin reptech inhibitarsarkhya krutimule, sahishnu vyaktinmadhye manoranjak matrechi achanak thambavanyamule, ssris madhoon maghar ghenyasarkhich mansik aanee sharirik maghar lakshane disu shakatat. heey paise kadhoon ghenyache parinam nairashya, chidchidepana, bhook aanee sharirik parinam, susti, shariratil vedna aanee apriy kalakal yasah, saumya 'vidyut dhakkyachya' ulat, mansik parinam mhanoon prakat houu shakatat.
parinam.
dextromethorphane parinam chaar patharanmadhye vibhagale gele aahet. pahilya patharavar (1.5 teey 2.5 mii. gra. prati kilo sharirachya vajanatil) anand, shravanvishayak badal aanee gurutvakarshanachya aakalanshaktitil badal asey varnan kele aahe. aahe patharamule (2.5 teey 7.5 mii. gra./kilo) tivra utsah, spasht kalpanashakti aanee dolhe bund karoon bhram nirman hoto. tisare aanee chauthe pathar (7.5 mii. gra./kilo aanee tyahoon adhik) chetanet khol badal ghadavun aanatat aanee vaparkarte anekada sharirachya bahereel anubhav kinwa tatpuratya manovikarachya takrari detat. yamule eka prakarcha sanvedi input flang (veg vadhavane aanee/kinwa mand karane) hoto, joou manoranjanatmak vaparacha aanakhi eka vaishishtyapurn parinam aahe.
tasech, bahutek khokala dadapanyachya aushadhanmadhye asalele dextromethorphan hydrobromide aanee brand neem tayari delsimmadhye asalele dextromethorphan polystyrex yanchyat lakshaniy farak disun yeto. polystyrex haah eka polymer aahe joou dextromethorphanshy jodalela asato, jyala pooat pachavanyasathi adhik vel lagato, kaaran tyasathi raktat virghalanyapurvi aayan vinimay pratikriya hone aavashyak asate. yamule, dextromethorphan polystyrex shoshayala barach vel lagato, parinami velechya sutanyachya golyanchi aathvan karoon denare adhik haloohaloo aanee dirghkal tikanare parinam hotat. khokala dadapanyache aushadh mhanoon, polystyrexchi aavrutti 12 tasanparyant tikate. jevha too manoranjanasathi vaparla jaato tevha dekhil haah kalavadhi lagoo hoto.
1981 madhye, goselinchya eka peparne andaj vartavala qee pranghatak matra 50 teey 500 migra/kilo darmyan aahe. kahee manoranjak vaparkarte 15-20 mii. gra./kilo itake uchch doses ghetat. eka cases studiveroon asey soochit hote qee dextromethorphane atimatreche aushadh mhanje naloxone, jeey antahshira paddhatine dile jaate.
pii. see. pii. sarkhe mansik parinam nirman karnyavyatirikt, uchch matremule kahee aushadh chachanyanmadhye pii. see. pii. aanee opietsasathi chukiche-sakaratmak parinam houu shakatat.
vaparashi sambandhit jokhim.
ketamineshy samya asalyamule, asey houu shakate assa prarambhik andaj asoonahi, dextromethorphanemule pranyanmadhye vaculization jhalyache disun aalele nahee, jyala olnichya jakhama asehi mhanatat. undaranmadhye, dextromethorphane tondawate dilelya vaparamule prayogshaletil chachanyanmadhye nirvat hott nahee. tathapi, paugandavasthet varanvar dextromethorphane tondawate sevan kelyane praudhavasthet tyaa undaranche shikshan bighadalele disun aale aahe. tathapi, manavanmadhye olanichya jakhamanchi ghatana siddha kinwa nakarli gelee nahee. william eae. dxm faq' chey lekhak white yanni dextromethorphan vaparkartyansobatchya patravyavaharatun anaupacharik sanshodhan sankalit kele aahe, jeey asey suchavatat qee mothya pramanat durupyog kelyane olnichya jakhmanmule prabhavit jhalelya menduchya bhaganshi sambandhit vividh kamatarata udbhavu shakatat; yamadhye episodic memarichi haanee, shikanyachi kshamata qamee hone, drushya prakriyechya kahee pailunmadhil vikrutee aanee amoort bhasha aakalanshaktichi kamatarata yancha samavesh hoto. matra, 2004 madhye whiteney jyaa lekhat heey dave kele hote too lekh mage ghetala.
dextromethorphan vaparkartyanchya aupcharik sarvekshanat asey disun aale aahe qee ardhyahun adhik vaparkartyanni dirghkal/vyasanadhin dextromethorphane vaparanantar pahilya aathvadyasathi vaiyaktikaritya yaa maghar ghenyachya lakshanancha anubhav nondavalah thakwa, udasinata, flashback aanee baddhakoshthata. eka chaturthanshpeksha jaast lokanni nidranash, duhswapna, enhedonia, ashakt smaranshakti, laksh qamee hone aanee kamvasna qamee hone nondavale. durmil dushparinamadhye panic attack, bighadalele shikshan, comp, kaveel, artikeriya (sheetpitt) aanee myalgia yancha samavesh hota. vaidyakeey dii. ex. emm. chya vaparamule vareel samasya udbhavalyache disun aalele nahee.
khokala dadapun takanare aushadh vaparnyaivaji, jyacha ekmev sakriy ghatak dextromethorphan aahe, bahu-lakshan asalelya sardichya aushadhancha gairavapar kelyane mrutyu kinwa gambhir aajaar honyacha lakshaniy dhoka asato. bahuvidh lakshane asalelya sardichya aushadhanmadhye paracetamol (acetaminophen), chlorpheneramine aanee fenilefrin yasarkhe itar sakriy ghatak asatat, jyapaiki konatihi mootrapind nikami hone kinwa samanyatah swikarlelya dextromethorphane manoranjak matra pramanavar ghetalyas mrutyusarkhe kayamswarupi sharirik nuksan karoo shakate. dextromethorphan asalelya khokalyachya anek sirapmadhye aadhalanare krutrim god padarth sorbitolche nakaratmak dushparinam dekhil houu shakatat, jyamadhye dextromethorphane manoranjak matret ghetalyavar atisar aanee malmal yasah nakaratmak dushparinam houu shakatat. khokalyachya tayareet samanyatah dextromethorphans yenare kafnashak, gwyphenesin, ulatya, malmal, mutrapindatil dagad aanee dokedukhi yasah apriy lakshane nirman karoo shakate.
dextromethorphan itar padarthansah ekatra kelyane jokhim vadhu shakate. amphetamine aanee/kinwa koken sarkhya kendriya majjasansthetil (see. aine. ess.) uttejak padarthanmule raktadab aanee hrudayache thoke dhokadaykaritya vadhu shakatat. ethanol (madyapan) sarkhya see. aine. ess. avasadjantuncha ektrit avasadaj prabhav asel, jyamule shwasan darr qamee houu shakato. dextromethorphan aanee itar itar tharanchya sanyogamule donhi aushadhe raktpravahat dhokadayak pataliparyant vadhu shakatat. dextromethorphan aanee itar serotonergic aushadhanchya sanyogamule serotonin vishaktata, see. aine. ess. aanee paridhiy majjasansthetil serotonergic kriyakalapanchi vaadh houu shakate.
aushadhashastra.
dextromethorphan heey pramukhyane sigma receptor agonist aanee eka snoory aahe aanee disociative halucinogen mhanoon dextromethorphane parinamanche anshatah kaaran dextrorphan (dxo) asey manale jaau shakate, jeey shariradvare dextromethorphane chayapachay kele jaate tevha tayar honare chayapachay aahe. dextrorphan aanee dextromethorphan heey donhi aine. emm. dii. aii. receptor virodhi aahet, tyachpramane ketamine aanee pii. see. pii. sarkhya itar vighatit helucinogence aahet. jaree dextrorphan tyachya "mool renu" dextromethorphanepecsha adhik shaktishali asale, taree dextromethorphane keval thodya takkevariche chayapachay dextrorfenmadhye hott asalyamule teey dextromethorphane sanyogane helucinogenic prabhav nirman karnyasathi karya karate.
aine. emm. dii. aii. receptor antagonist mhanoon, dextrorphan aanee dextromethorphan heey mendutil uttejak amino acid aanee neurotransmitter glutamatela pratibandhit karatat. heey menduchya bhaganna ekmekanshi sanvad sadhanyapasun rokhoon dharoo shakate, kahee majjatantunche marg prabhavipane mand karoo shakate kinwa bund dekhil karoo shakate. yamule vaparkartyala mendutil dhukn kinwa nirjalikaran mhanoon anubhavale jaanare, vegale kinwa disconnect jhalele vatate.
kayadesheerpana.
dextromethorphan asaleli antitucive tayari bahutek deshantil aushadhalayankadun kharedi karane kayadeshir aahe, kahee apavad mhanje yuu. aii. eae., france, sweeden, estonia aanee lavia. russiamadhye, dextromethorphan (samanyatah tussin + aanee glycodine yaa brand navankhali vikala jaanara) haah eka anusuchi III niyantrit padarth aahe aanee too benzodiazepines aanee bahusankhya barbituretschya samaan yadeet thewala jaato. lakshat ghya qee rashiyatil aushadhanche velapatrak united statesmadhil aushadhanchya velapatrakapeksha vegale aahe.
united states.
vaidyakeey aanee karamanukisathicha vapar, vikri kinwa kharedi yanchyat sadhya americet konatahi kayadeshir farak astitvat nahee. kahee rajye aanee dukan sakhalyanni nirbandh lagoo kele aahet, jase qee dii. ex. emm. vikrisathi vikrisathi karane aavashyak aahe, kharedisathi parvanagi asalelya pramanat maryada ghalane aanee kharedidar tyanchya rajyat praudh vayapeksha jaast asane aavashyak aahe. jaree eleanoy vyatirikt, tyachya vikrivar kinwa tabyat ghenyas pratibandh karnara konatahi spasht kayada astitvat nasla taree, dextromethorphane shuddha choorn swarupat vikri kelyas dand aakarla jaau shakato. vaidh aushadhanchya vikrisathi adhik samanya kayadyanche aanushangik ullanghan-jase qee yogya chetavani lableshivay aushadhachi punarvikri-yaa karanastav, yaa swarupat shuddha dextromethorphan vikalyabaddal vyaktinna turungat aanee itar dandanchi shiksha sunavanyat aalyachi prakarane nondavali gelee aahet.
dextromethorphanla 1970 chya niyantrit padarth kayadyatoon (see. ess. aii.) vagalanyat aale aanee madak aushadhanvaril ekach kararatoon tyala visheshtah vagalanyat aale. 2010 paryant, too ajunahi yuu madhoon vagalanyat aala hota.ess. niyantrit padarthanche velapatrak; tathapi, tathapi ishara deela aahe qee durupayogat vaadh jhalyas tyache velapatrak nishchit kele gele taree teey ajunahi jodale jaau shakate. see. ess. aii. madhoon tyala vagalanyamagil prerana ashee hotee qee see. ess. aii. antargat, soochibaddha anusuchi II opiatesche serve optical isomers svayamchalitapane anusuchi II padarth asatat. dextromethorphan haah anusuchi II opiate levomethorphane optical isomer asalyane (parantu opietsarkhe karya karat nahee), too aniyantrit padarth thevanyasathi suut aavashyak hotee. dextromethorphanla federal analogue kayada lagoo hott nahee kaaran tyasathi naveen aushadh arj dakhal karnyat aala aahe.
indoneshiya.
purvi countervar upalabdh jhalyanantar, indoneshiya prajasattakachi aushadh aanee ann niyantranachi rashtriy sanstha (bii. pii. oo. emm.-aar. aay.) aata prescriptions kinwa tyashivay eka-ghatak dextromethorphan aushadh vikrivar bandee ghalate. indoneshiya haah jagatil ekmev desh aahe joou prescriptiondware dekhil eka-ghatak dextromethorphan bekaydeshir banavato aanee ullanghan ullanghan kayadyane khatala chalavala jaau shakato. indonesian rashtriy ammali padarth vibhagane aushadhavikretyanche aanee aushadhanchya dukananche parvane radd karanyachi dhamki dilee aahe, jarr tyanni ajunahi dextromethorphane satha keela tarr teey faujdari khatala chalvanyasathi polisanna soochit kartil. yaa niyamacha parinam mhanoon, 130 aushadhe bajaratoon mage ghenyat aalee aahet, parantu bahu-ghatak dextromethorphan asaleli aushadhe countervar vikali jaau shakatat. aaplya adhikrut prasiddhipatrakat, beurone asehi mhatale aahe qee amali padarthancha durupyog durupyog dextromethorphane vapar anekada ganja, amphetamine aanee heroinecha paryay mhanoon keela jaato aanee aaj tyacha antitucive mhanoon vapar qamee fayadeshir aahe.
ammali padarth, cycotropics aanee vyasanadhin padarth niyantran (napza) bii. pome-rii, dow. daxtromethorphan, morphene aanee heroin ekach zadapasun tayar kele jaatat aanee dextromethorphane prabhav morphene aanee injection kelelya heroinchya 1/100 chya samatulya asalyache danrdy sosrosumihardjo, spkj spasht karate.
yaulat, upcharatmak utpadanache up aanee napza paryavekshan bii. pii. oo. emm.-rii, dra. antonia reto tias utami, yogya. mapid., asey sangate qee dextromethorphan, rasayanikdrushtya morphinsarkhe asalyane, kendriya majjasansthevar adhik dhokadayak aanee thet parinam hoto, jyamule vaparkartyat mansik bighad hoto. konatyahi purvichya vaidnyanik abhyasacha kinwa punravalokanacha hawala naan deta, morphene vaparkartyanpramane, dextromethorphan vaparkartyanche punarvasan kele jaau shakat nahee, assa davahi tine keela. yaa davyala asankhya vaidnyanik abhyasanni virodh keela aahe, jeey darshavtat qee ektech naloxone prabhavi upchar dete aanee dextromethorphan vyasan aanee vishbadhevar upchar karnyasathi aashadayak upchar parinam dete. dra. antonia reto tayas utamine indoneshiyamadhye dextromethorphane durupyogache uchch praman-mrutyunsah-asalyacha dawa keela aanee tyahunahi adhik sanshayaspad, asey suchavale qee kodeen, adhik sharirik vyasankari micro-opioid varg pratijaivik asoonahi, dextromethorphanla paryay mhanoon upalabdh karoon dile jaave.

