
lipocallin

lipocallins heey prathinanche eka kutumb aahe jeey steroids, billins, retinoids aanee lipids sarkhya lahan hydrophobic renunchi vahtook karatat aanee bahutek lipocallins dekhil guntaguntichya lohashi (cyderophores kinwa flavonoidsdware) tasech hemshi bandhanyas saksham asatat. teey anukram samarupata aanee samaan trutiyak rachana sanrachaneche maryadit kshetra samayik karatat. hii aath adakaleli samantar beeta baryl aahe, jyat punaravrutti + 1 topology antargat legand bandhanyachya thikanala vedhate.
hii prathine graam negative jivanu, prushthavanshiy peshi aanee aprushthavanshi peshi aanee vanaspatinmadhye aadhaltat. rogpratikarak pratisad, ferromon vahtook, jaivik prostaglandin sanshleshan, retinoid bandhan aanee karkarogachya peshinchya parasparsanvad yasarkhya anek jaivik prakriyanshi lipocallinscha sambandh aahe.
karya.
rogpratikarak pratisad.
sookshm poshakdravye rokhoon aanee vegale karoon lipocallin prathine hii poshanksham pratikarshaktichi mahattvachi ghatak aahet. tyadvare teey sastan pranyanmadhye rogpratikarak pranali sakriy jhalyamule honanya dahak aanee nirvishikaran prakriyanche niyaman karnyas saksham asatat. teey under, manjar, kutre, ghode aanee itar pranyanchya shwasan ellergykarak mhanoon olakhale jaatat. rogpratikarak pranalichya pratisadat samavisht asalelya lipocallin prathinanchya udaharananmadhye alfa-1-microglobulin, alfa-1-acid glycoprotein aanee see8gagaaiimaamaaa yancha samavesh hoto. lipocallin prathinanvar prabhav takna anek rogpratikarak pranalisathi sanrachanatmak mahitee upalabdh aahe, tarr jaivik pranalinmadhye tyanchi achook bhoomika ajunahi kahishi aspasht aahe. lipocalinchi allergykarak dravye tyanchya apo-swarupat (legands nasalela rikama calixs) lavlyas, elarjisanvedanshilatesathi mahattvacha, tii. etch. 2-vichalit rogpratikarak pratisad nirman karatat asey disun aale aahe, tarr hooloo-form rogpratikarak-damankari gunadharm "inn vitro" lavto asey disate.
ferromon vahtook.
sahajpane nirikshan karnyayogya prathine-ferromon parasparsanvadamule lipocallin kutumb sastan pranyanchya ferromonechya vahtukishi jodalele aahe. lipocallins aakarane tulanene lahan asatat aanee tyamule mothya, avjad prathinanchya tulanet abhyas karane qamee klisht asate. teey vegvegalya jaivik karanansathi vividh ligandsna dekhil bandhu shakatat. kruntakanchya anunasik shleshmalamadhye mahattvachya ferromonschi vahak prathine mhanoon lipocallins aadhalali aahet. pramukh mootra prathine, eka lipocallin upkutumb, under aanee undaranchya mutrat aadhaltat aanee swatah prathine ferromon mhanoon karya karoo shakatat.
prostaglandin sanshleshan.
prathinanche heey kutumb antim prostaglandin sanshleshanachya jaivik pranalimadhye bhoomika bajavate.
retinoid bandhan.
retinol (aaa jivansatva) heey eka mahattvache sookshm poshak tatva aahe jeey drushti, peshinche vegalepan, rogpratikarak pranaliche karya, hadanchi vaadh aanee gaath dadpan yavar parinam karate. retinolche shoshan aanee chayapachay heey lipocalinsvar avalambun asate jeey bandhankarta prathine mhanoon kaam karatat. retinyal ester (mansamadhye asalele) aanee beeta-carotene (vanaspatinmadhye asalele) heey aaharatil retinoidche done mukhya srot aahet. sevan kelyanantar, teey retinolmadhye rupantarit hotat, kramakramane chayapachay hotat aanee shevati rakt plazmamadhil retinol bandhan prathinanshi (lipocallins) bandhale jaatat.
karkarog peshinchi parasparkriya.
kaaran lipocallins heey bahyakoshikiy prathine aahet, tyanche antahkoshikiy parinam spasht naheet aanee pudhil abhyasachi magani karatat. tathapi, lipophilic legands, lipocallinsche paryay mhanoon upasthit asatat, peshimadhye pravesh karanyachi kshamata asatat, jithe teey tumour protease avarodhak mhanoon karya karoo shakatat. heey sanshodhan prathine-tumour tapasanicha aanakhi eka sambhavya marg suchavate.
ellergykarak.
yaa kutumbatil kahee prathine ellergykarak asatat. allergy mhanje allergykarak (jase paragkan, dansh, aushadhe kinwa ann) navachya vishisht padarthambaddal rogpratikarak shaktichi atisanvedanshilata pratikriya, jyamule bahutek lokanmadhye konatihi lakshane disun yet naheet. manavanmadhye aay. jee. eae.-madhyasthi atopic allergy nirman karananya pratijanansathi (allergykarak) namkaran pranali sthapit kelee gelee aahe. hii namkaran pranali pahilya teen padnamanni banalelya padnamadware paribhashit kelee jaate.
vanshatil akshare; eka jaaga; prajatichya navache pahile akshar; eka jaaga aanee eka arabi sankhya. done prajatinchya navanmadhye samaan padnam asalyas, pratyek prajatichya padnamat eka kinwa adhik akshare (aavashyak asalyas) jodoon tyanchyat ekmekanpasun bhedbhav keela jaato.
yaa kutumbatil elarjikarkanmadhye khaleel sandnyansah allergykarak ghatak samavisht aaheth blah jee 4, boses dii 2, boses dii 5, cann eff 1, cann eff 2, phela dii 4, ikwal see 1 aanee ikwal see 2.
samprerak.
ell. see. aine. 2 (lipocallin 2) hadanpasoon tayar jhalele samprerak mhanoon karya karate jeey bii. bii. bii. paar karate aanee mendutil hypothalamuschya pii. vhee. aine. paraventricular kendrakavar karya karate.
rachana.
jaree lipocallins heey atyant vaividhyapurn prathinanche eka vistrut kutumb asale, taree tyanchi trimiteey rachana heey eka ekikrut vaishishtya aahe. lipocalinsmadhye aath-stranded, antiparallel, samamiteey β-baryl fold asate, jeey, thodakyat, eka beeta sheet aahe jeey dandgolakar aakarat gundallele aahe. yaa nalichya aat legand bandhanyachi jaaga aahe, jee vahtook prathine mhanoon lipocalinchya vargikaranat mahattvachi bhoomika bajavate. jarr lipocallins tyanchya bandhan gunadharmat badal karnyachya prayatnat anuvanshikdrushtya tayar kele gele asateel tarr tyanna anticallins mhanatat.
kutumbatil sadasya.
yaa prathine kutumbasathi 'lipocallin' heey naav prastavit kele gele aahe, parantu cytosolic fatty acid binding prathine dekhil samavisht aahet. kutumbatil bahutek sadasyanche, coor kinwa curnell lipocallinsche anukram, avasheshanchya teen lahan sanrakshit pattyandware darshavile jaatat, tarr itar, bahya lipocallin gut, yapaiki keval eka kinwa done samayik karatat. yaa kutumbatil asalelya prathinanmadhye alfa-1-microglobulin (prathine etch. see.); pramukh mootra prathine; alfa-1-acid glycoprotein (orosomucoid); afrodicin; apolypoprotein dii; beeta-lactoglobulin; purak ghatak see8 gama sakhali; crustacianin; epididimal-retinoic acid binding protein (eae-rabb); insectacyanin; gandhyukt binding protein (oo. bii. pii.); manvi garbhadharaneshi sambandhit endometrial alfa-2 globulin (pii. eae. pii.); probassin (pii. bii.), eka prostatic protein; prostaglandin dii synthes; purpurin; wonn ebnerchi granthi protein (ways); aanee epidimal livisard protein (gupt datarsandhi) yancha samavesh hoto.
lipocallinche kshetra asalelya manvi prathinanmadhye khaleel goshtincha samavesh hotoh