myeloperoxidase

myeloperoxidase (emm. pii. oo.) heey eka peroxidase enzyme aahe jeey manavanmadhye gunasutra 17 vareel "emm. pii. oo." janukadware encode kele jaate. emm. pii. oo. heey neutrophil granulocytesmadhye granulocytesmadhye raktapesheencha eka upprakar) sarvat jaast pramanat vyakt kele jaate aanee hypochlorus acids tyanchi pratijaivik kriya karnyasathi hypohalus acid tayar karate, jyatil soodiyam meeth heey bleachmadheel rasayan aahe. heey neutrophilchya azurophilic granulemadhye sathavalele aanee degranulation darmyan bahya koshikeey jaaget sodale jaanare eka lysosomal prathin aahe. neutrophil myeloperoxidasemadhye heema rangdravya asate, jyamule shleshma aanee thunkisarkhya neutrophilne samruddha asalelya sravanmadhye tyacha hirwa rung hoto. hiravya rangane tyachya junya naav verdoperoxidasemadhye yogdan dile.
rachana.
150-kilo kilo meterche emm. pii. oo. prathin heey eka catanic heterotetrammer aahe jyamadhye done 15-kilo meterchya prakash sakhali aanee done chull-vajanachya glycosylated judd sakhali asatat jyaa calcium ions krutrim heema gut sankulala bandhalya jaatat, jeey heterodimerche samaroop mhanoon mandanyat aale aahet. prakash sakhali glycosylated asatat aanee tyat sudharit loh protoporpherin ix sakriy jaaga asate. ektritpane, halakya aanee judd sakhalya see. aay. ess. 153 yetheel cysteine brijdware jodalelya done samaan 73-keey. dii. aii. monomers tayar karatat. prathine eka khol daree tayar karatat jee heema gatala talashi thevate, tasech durastha heema pokalichya praveshdvaravar hydrophobic pockett tayar karate jee tyachi utprerak kriya karate.
teen samarupata olakhalya gelya aahet, jyaa keval judd sakhalyanchya aakarat bhinn aahet.
legandspacky eka mhanje aii. ess. pii. 96 chaa carbonyl gut. aii. ess. pii. 96 utprerak tyachya 95 bajuchya sakhalichya jawal asalyamule sakriy jagechya sanrachanesathi calcium-bandhan mahatvache aahe.
karya.
emm. pii. oo. haah peroxideceschya ex. pii. oo. upkutumbatil eka sadasya aahe aanee neutrophilchya shwasan sphotadarmyan hydrogen peroxide (etch. 2. oo. 2) aanee chloride aayan (see. ell.-) (kinwa bii. aar.-asalyas hypobromous acid) pasoon hypochlorus acid (etch. oo. see. ell.) tayar karato. tyasathi cofactor mhanoon hemchi aavashyakta asate. yavyatirikt, teey oxidising agent mhanoon hydrogen peroxidecha vapar karoon tyrosineche tyrosyl radicalmadhye oxidization karate. hypochlorus aaml aanee tyrosyl radical heey cytotoxic asatat, mhanoon teey neutrofildware jivanu aanee itar rogjankancha naash karnyasathi vaparale jaatat. tathapi, heey hypochlorus aaml yazman uutinmadhye oxidative nuksan dekhil karoo shakate. shivay, epoa-aayache emm. pii. oo. auxidation apoptosis aanee jaljalicha etch. dii. ell.-madhyasthi pratibandh qamee karate. yavyatirikt, emm. pii. oo. prathinanche nitrocillation aanee 3-chlorotyrosine aanee dietrocene cross links tayar karnyat madhyasthi karate.
vaidyakeey mahatva.
myeloperoxidase kamatarata hii enzymechi aanuvanshik kamatarata aahe, jee rogpratikarakshaktichya kamatarates pravrutt karate.
emm. pii. oo. viruddhachya pratipinde vividh prakarchya vasculitismadhye samavisht kelya gelya aahet, sarvat thalakpane teen vaidyakeey aanee rogshastriy manyataprapt prakarah polyengitis granulomatosis (jee. pii. aii.), microscopic polyengitis (emm. pii. aii.); aanee polyengitis eosynophilic granulomatosis (eae. jee. pii. aii.). pratijaivikanna anty-neutrophil cytoplasmic pratijaivik (aii. aine. see. aii.) mhanoon dekhil olakhale jaate, jaree perinuclear pradeshachya daganmadhye dekhil aii. aine. see. aii. aadhalale aahet.
alikadil abhyasanmadhye myeloperoxidase vadhaleli patali aanee coronary dhamani rogachi tivrata yanchyatil sambandh nondavala gela aahe. aanee heslop aanee itar. emm. pii. oo. chya vadhalelya patalimule 13 varshanchya kalavadhit hriday v raktavahinyansambandhi mrutyucha dhoka duppat jhaala aahe asey nondavale gele. atherosclerotic jakhamechya vikasat aanee plake asthir banavanyat myeloperoxidase mahattvapoorn bhoomika bajavate asehi suchavale gele aahe.
vaidyakeey vapar.
2003 chya suruvatichya abhyasat asey suchavale gele aahe qee chhatichya dukhapatimule grast asalelya rugnanmadhye emm. pii. oo. haah hrudayavikarachya vadhicha sanvedanshil andaj lavnara asoo shakato. tevhapasoon, emm. pii. oo. chachanichya upayuktateche dastaivajikaran karnare 100 hoon adhik prakashit abhyas jhaale aahet. 2010 heslop aanee itar. abhyasat asey nondavale gele aahe qee emm. pii. oo. aanee see. aar. pii. (see-pratikriyashil prathine; jaljaliche samanya aanee hriday-sambandhit chinhak) yaa donhiche mojmap kelyane keval see. aar. pii. mojanyapeksha jokhamichya andajasathi atirikt fayda jhaala.
leukemic peshi myeloid vanshatoon tayar jhalya aahet heey darshavinyasathi tivra myeloid leukemiachya nidanat myeloperoxidasesathy immunohystochemical daag deela jaat asey. myeloperoxidase daag haah myeloid sarkomachya nidanat ajunahi mahattvacha aahe, joou lymphomachya nakaratmak daganchya ulat aahe, jeey anyatha samaan disu shakatat. vasculitischya rugnanchya tapasanichya babatit, pravah cytometric parikshananni rogpratikarak fluorescence chachanyanprati tulanatmak sanvedansheelata darshavili aahe, vasculitisashi sambandhit anek svayampratibandhak ekach velee shodhanyachya atirikt fayadhyasah. tathapi, yaa paddhatisathi ajunahi adhik chachanichi aavashyakta aahe.
myeloperoxidase heey carbon nanotubesche vighatan karnare pahile aanee aataparyantche ekmev manvi enzyme aahe, jyamule aushadhanchya lakshyit vitaranasathi nanotubescha vapar kelyane uutinmadhye nanotubeschi aswasth nirmiti hoil hii doctoranmadhil chinta door hote.
emm. pii. oo. chey avarodhak.
ezidecha vapar paramparikpane emm. pii. oo. avarodhak mhanoon keela jaato, parantu 4-eminobenzoic acid hydrazide (4-aii. etch.) haah emm. pii. oo. chaa adhik vishisht avarodhak aahe.

