
shock 2

lucine-samruddha punaravrutti (ell. aar. aar.) prathine shock-2 hii eka prathine aahe jee manavanmadhye shock 2 janukadware encode kelee jaate. shock 2 chee sarvottam abhyasaleli bhoomika mhanje bahya koshikeey sanket-niyantrit keynage 1 aanee 2 (ark 1/2) margachya sanketanche modulation karoon, eka holophosphates complexes tayar karane jeey raaf prathine () sakriy karate. heey prathin suruvatila 'synorhabditis elegans' madhye suur-8/ess. oo. see. 2 mhanoon olakhale gele hote aanee teey aii. aar. keey. 1/2 sanket margache eka gambhir sakaratmak niyamak asalyache aadhalun aale jeey aii. aar. keey. 1/2 margachya raas aanee raaf ghatakanna bahuprathine sankulat ektrit karate. visheshtah, shock 2 raas aanee pii. pii. 1. see. prathinanna ekatra aanate aanee mapke signalling saksham karnyasathi rafchya jawal defosphorylate "ess259" chya jawal asate. asey disun aale aahe qee jyaa kriyakalapanmule shock 2 chey lipidation (visheshtah myristoilation) hote, tyamule madhyahn syndrome houu shakato.
parasparsanvad.
shock 2 utprerak phosphates upghatak pii. pii. 1 see. () aanee emm. aar. aii. ess. tasech canonical raas isophorms (etch/keey/aine. aar. aii. ess.) () shhee parasparkriya karat asalyache disun aale aahe. mapke signalling () saksham karnyasathi tri-stariy sankul shock2-raas-peepi1see heey raff kutumbatil prathinanvar avarodhak phosphorylation site ('ess259') defosphorylate karnyasathi karya karate.
mapke signalingache shock2 avalambun gatishil niyaman.
shock2-madhyasthi erke1/2 sanketanche amplitude plazma membrain aanee antargat endosome compartment () yethe raff sakriyatechya vibhedak niyamanadvare tasech anuvadanantarchya badalancha prastav asalelya paryayi modeldware niyantrit karnyacha prastav aahe. hyuve1 dware madhyasthi kelele shock2 sarvyapikaran heey ark1/2 margachya vadhichya ghatak sakriyatemule suru hote aanee shock2 shhee sambandhit raf-1 kinesachya tyanantarchya sarvyapitesathi hii purvat aahe. tathapi, sadhyachi mahitee hii aahe qee heey ubquitin badal raf-ark1/2 sanketanche amplitude qamee karnyasathi soc2 holophosphates karya kase niyantrit karatat.