stame selcha vruddhatvacha siddhant

vruddhatvacha stame seela siddhant asey gruheet dharato qee vruddhatva prakriya hii vividh prakarchya stame peshinchya tyaa uutinche (kinwa avyavache) mool karya rakhanyas saksham asalelya karyatmak bhinn pesheensah jivanchya uutinchi punha bharr ghalanyat asamarthatecha parinam aahe. vayachi parva naan karata anuvanshik samgrimadhye nuksan aanee truti sanchay hii pranalisathi nehmich eka samasya asate. tarun lokanmadhye stame peshinchi sankhya vruddha lokanpeksha khoop jaast asate aanee asha prakare vruddhanchya ulat tarunanmadhye eka changli aanee adhik karyaksham punarsthapana yantrana tayar hote. hote shabdant, vruddhatva hii haanee vadhavanyachi baab nahee, tarr moolpeshinchi sankhya qamee jhalyamule tee badalanyat ayashasvi honyachi baab aahe. moolpeshinchi sankhya qamee hote aanee tee santati kinwa lasika vansh aanee myeloid vanshanmadhye farak karanyachi kshamata gamavatat.
stame seela poolche gatishil santulan rakhanyasathi anek atinchi aavashyakta asate. prasar aanee shantatesah santulan sadhane aanee hoome ('aala' pahaa) aanee hematopoetic stame peshinche swayam-nutanikaran heey stame seela poolchya dekhbhalichya ghatakanche samarthan kareet aahet, tarr farak, gatishilata aanee vruddhatva heey hanikarak ghatak aahet. yaa hanikarak parinamanmule akheris apoptosis hoil.
stame peshincha upcharatmak vapar aanee avyav aanee ootee punha bharnyachi tyanchi kshamata hyamadhye dekhil anek aavhane aahet. pratham, vegvegalya peshinche ayushya vegvegale asoo shakate, jaree teey ekach mool peshinmadhun udbhavtat (tii-peshi aanee erythrocytes pahaa), yacha arth assa qee qamee ayurman asalelya peshinchya tulanet jyaa peshinche ayurman jaast aahe, tyamadhye vruddhatva bhinn prakare houu shakate. tasech, sharirik peshi badalanyachya satatchya prayatnanmule moolpeshincha thakwa yeu shakato.
sanshodhan.
yaa siddhantache kahee samarthak norman eae aahet. tikshna, ronald aaa. depinho, huber worner, alessandro testori aanee itar. huppinson gilford syndromechya manvi prakarananche aanee vegwan vruddhatvachya undaranchya namunyanche vishleshan kelyanantar worner haah nishkarsh kadhala.
sharirala aavashyakatenusar stame peshi vishisht peshinmadhye rupantarit hotil. stame peshi naun stame peshinpeksha jaast vibhajit hotat tyamule nuksan jamaa karanyachi pravrutti jaast asate. jaree tyanchyakade snrakshak yantrana asali taree, teey ajunahi vayane mothe hotat aanee karya gamavatat. mathyu aar. wallenfang, renuka nayak aanee stephen dinardo yanni tyanchya abhyasat heey dakhavun dile. tyanchya nishkarshannusar, ushmaghatasaha punarsanyojan prerit karoon aanee vruddhatvabarobar jee. ess. see. sankhyet ghat jhalyache nirikshan karoon, 'drosophila' modelmadhye lacz janukasah label kelele purush jee. ess. see. chaa magova ghene shakya aahe. jee. ess. see. laa lacz janukasah chinhankit karnyasathi, sarvavyapi sakriy tubulin pravartak aanee tyanantar eff. aar. tii. (flip recombiness target) sitela eff. aar. tii. sitechya aadhi pravartakvirahit lacz oo. aar. eff. (open reading frame) saha ekatra karnyasathi, flip recombiness (eff. ell. pii.)-madhyasth punarsanyojan vaparale jaate. ushmaghat eff. ell. pii. punarsanyojanasathi vaparla jaato, marker januk abhivyakti punarsanyojanamule vibhajit peshinmadhye sakriy hote. parinami, jee. ess. see. pasoon prapt jhalelya peshinche serve pratirup karyatmak lacz janukane chinhankit kele jaatat. chinhankit peshincha magova gheuun, teey heey dakhavu shakale qee jee. ess. see. chey vay vadhate.
undaranchya pratikrutitil aanakhi eka abhyas darshavito qee stame peshinche vay vadhate aanee tyanche vruddhatva hrudayavikarachya zatkyala karanibhoot tharoo shakate. abhyasache nishkarsh asey soochit karatat qee madhumehamule akali myocyte vruddhatva aanee mrutyu hoto aanee ektritpane snayu vastuman qamee jhalyamule cardiomyopathycha vikas hoto.
alikadil abhyasane asey suchavale aahe qee, jaree praudh ootee mool peshi vruddhatvachya prakriyet pramukh peshi prakar asoo shakatat, taree tyaa thakoon jaanyaivaji tyanche bhinnateche praman qamee karoon yogdan deu shakatat. yaa pratimanantargat, jevha moolpeshi vibhajit hotat parantu vegale karat naheet, tevha tyaa dotter moolpeshi adhik pramanat tayar karatat. jarr heey aanuvanshik epigenetic badal kinwa anuvanshik utparivartananmule jhaale asel aanee nantarchya aayushyat jivanchi akhandata qamee hott asatana peshi sankhyanche homeostatic niyaman qamee karanyachi kshamata asel tarr haah phenotype cellular staravar nivadala jaeel.
pahanare aanee itar. stame peshi aanee stame peshi sookshm vatavaran asalelya peshi yaa donhimadhye vay-avalambun dii. aine. aii. chey nuksan, kiman kahee pramanat, vruddhatvachya velee stame peshichya karyakshamatela jababdar aahe, yaa puravyancha aadhava ghetala aahe.
hematopoetic stame seela vruddhatva.
hematopoetic stame cells (etch. ess. see. ess.) ayushyabhar rakt pranaliche punarutpadan karatat aanee homeostasis rakhatat. vruddhatvachya kalat dirghakalin etch. ess. see. madhye dii. aine. aii. strand break jamaa hotat. heey sanchay dii. aine. aii. durusti aanee pratisad marganchya vyapak kshinateshi sambandhit aahe jeey etch. ess. see. shantatevar avalambun aahe. dii. aine. aii. ligaj 4 (ligg 4) chee naun-homologous end joining (aine. etch. eae. jeey.) dware duheri-strand breakchya durustimadhye atyant vishisht bhoomika aahe. undaratil ligg ligg kamataratemule vruddhatvachya kalat etch. ess. see. chee haloohaloo haanee hote. heey nishkarsh asey suchavatat qee kalantarane swatahla tikavoon thevanyachya etch. ess. see. chya kshamatecha eka pramukh nirdharak mhanje nej aahe.
hematopoetic stame selchi vividhata vruddhatva.
eka abhyasat asey disun aale aahe qee rakt peshi tayar tayar moolpeshinchi clonal vividhata vayachya 70 vya varshi mothya pramanat qamee hote, jyamule vruddhatvacha eka naveen siddhant siddha hoto jyamule nirogi vruddhatva shakya houu shakate.
gunasutra vayache hematopoetic mosack nuksan.
2022 chya abhyasat asey disun aale aahe qee 'gunasutra vaay' (mloy) chey mosack losses 'mhanoon olakhalya olakhalya peshinchya upasanchat vaay gunasutratil rakt peshinchi haanee aanee 70 varshe vayachya kiman 40 takke purushanvar kahee pramanat parinam karane, fibrosis, hrudayachi jokhim aanee mrutyudarat yogdan dete.
kesanchya thipkyachya stame selche vruddhatva.
vayanusar cases galanyacha eka mahattvacha pailu mhanje kesanchya thipkyanche vay vadhane. samanyatah, pratyek thipkeshi sambandhit moolpeshi kesanchya thipakeche nutanikaran karatat. kesanchya thipkyache vruddhatva heey vruddhatvachya darmyan stame peshinchya nutanikaranat jamaa jamaa dii. aine. aii. chya hanila satatchya pesheey pratisadadvare prathamik asalyache disate. yaa hanichya pratisadat kesanchya thipkyachya mulpeshinmadhil dii. aine. aii. nuksanala pratisad mhanoon neutrophil elastesdware ex. vhee. aay. aay. collegen prakarache proteolysis samavisht aahe. kolejanchya proteolysismule kharab jhalelya peshi nasht hotat aanee nantar kesanchya thipkyanche laghukaran hote.
siddhantachya virodhat purava.
alzheimer rog, antim tappyatil mootrapind nikami hone aanee hridayrog yasarkhe rog heey stame peshinshi sambandhit nasalelya vividh yantranemule hotat. tasech, applastic raktakshay aanee sampoorn asthimajja nikami hone yasarkhe hematopoetic pranalishi sambandhit kahee rog visheshtah vayavar avalambun nasatat. applastic raktakshay haah haah vishisht aushadhancha pratikool parinam asato, parantu tyamule too kharokharach stame selchya vruddhatvachya siddhantashi nigadit purava manla jaau shakat nahee. asthimajjyachi peshitva vayanusar qamee hote aanee samanyatah 100-vay yaa sutradvare mojali jaau shakate aanee heey vruddhatvachya moolpeshichya siddhantashi susangat asalyache disate. zaucha jeey. yanni prakashit kelela kutra abhyas.emm, yuu see. aanee mathyudakis jee., aanee itar."stame seela siddhantaviruddhache purave dekhil dakhavate. sastan pranyanchya pratikrutitil tarun aanee aanee majjyachya utkirnan gunadharmanchi prayogik tulana, kutra, vayanusar moolpeshichya karyat konatihi ghat darshavanyat ayashasvi tharala.
vruddhatvache itar siddhant.
vruddhatvachi prakriya vegvegalya siddhantanni spasht kelee jaau shakate. heey utkrantivadi siddhant, aanvik siddhant, pranali siddhant aanee cellular siddhant aahet. vruddhatvacha utkranti siddhant pratham 1940 chya uttaradhat prastavit karnyat aala hota aanee utparivartan (vruddhatvachi utkranti), disposable soma aanee virodhi pleotropy gruhitkadvare thodakyat spasht kele jaau shakate. vruddhatvachya aanvik siddhantanmadhye januk niyaman (januk abhivyakti), coden nirbandh, truti aapatti, sharirik utparivartan, anuvanshik samagriche sanchay (dii. aine. aii.) nuksan (vruddhatvacha dii. aine. aii. nuksan siddhant) aanee bhinnata yasarkhya ghatanancha samavesh hoto. pranalichya siddhantanmadhye vruddhatvacha rogpratikarak drushtikon, rahanyacha darr aanee neuroendocrinal niyantran yantranetil badal yancha samavesh hoto. (homeostasis pahaa). vruddhatvacha cellular siddhant telomere siddhant, mukt muldravyancha siddhant (vruddhatvacha mukt-kattarpanthi siddhant) aanee apoptosis mhanoon vargikrut keela jaau shakato. vruddhatvacha moolpeshi siddhant dekhil pesheey siddhantancha eka upvarg aahe.

