
anoroctoxin

anoroctoxin (α-ktx 6.12) heey mexican vinchuchya "anoroctonus phyodactylus" chya vishatoon tayar honare peptide aahe. heey neurotoxin heey potasium vahini karyarat peptideschya alfa kutumbatil aahe. haah kv1.3 vahinyancha uchch-aakarshan avarodhak aahe.
srot.
anoroctoxin heey eka peptide aahe jeey vinchu "anoroctonus phyodactylus" pasoon tayar kele gele aahe; haah vinchu vinchu kutumbatil ayurideshi sambandhit aahe.
rasayanshastra.
keey + vahinyanvar (keey. tii. ex.) karya karananya vinchuchya vishari padarthanche teen vegvegalya kutumbanmadhye vargikaran kele jaateh α-, β-aanee γ-vinchuchya vishari padarthanche. anroctoxin peptide haah α-ktx gatashi sambandhit aahe, jeey potassium vahinyanna avarodhit karnare lahan peptides aahet, jyat teen kinwa chaar diasulphide pool asalele 30 teey 40 amino acid asatat. jatijanya vishleshanavar aadharit, α-ktx jatijanya vrukshatil sahavya upkutumbat neuroctoxincha samavesh keela jaato; tyache paddhatshir naav α-ktx 6.12 aahe.
rachana.
anoroctoxinmadhye chaar diasulphide pools 35 amino acid asatat. tyache aanvik vajan 4082.8 daa aahe.
lakshya.
patch-clamp prayoganni asey darshavile aahe qee anoroctoxin haah kv1.3 (keey. dii. = 0.73 nm) potassium vahinyancha eka shaktishali avarodhak aahe. kv1.3/kcna3 vahinyanvyatirikt, anoroctoxin dekhil kv1.2 (kedee = 6 nm) potassium vahinyanna lakshaniyaritya pratibandhit karate. anoroctoxin khalilpaiki konatyahi vahinyanna avarodhit karat naheeh calcium-sakriy kca3.1/kcnn4 potassium vahinya, shekar iir, kv1.1/kcna1 aanee kv2.1/kcnb1 potassium vahinya.
krutichi paddhat.
potassium vahinyanche α-ktx pratibandh eka sadhya bimolecular plugging yantranedvare madhyasthi kelee jaateh bahya koshikeey chhidra, jyachi vishisht receptor site aahe, tyala bandhana ekach vishari renune bund kele aahe. haah block voltagevar avalambun aahe qee nahee, joou vinchuchya vishari padarthanmadhye samanya aahe heey pahane baakee aahe. haah chhidra khand matra purnapane ulat karata yenyajoga aahe, jyacha arth assa aahe qee too eka shaktishali neurotoxin nahee.