
clake10aii

see-type lectin domain kutumb 10 sadasya aii (clake10aii) jyala see. dii. 301 mhanoon dekhil olakhale jaate, heey eka prathine aahe jeey manavanmadhye "clake10aii" janukadware encode kele jaate. clake10aii haah see-prakarchya lectin super familicha bhag aahe aanee too 'aine'-acetylgalectosamine (galnack) shhee jodala jaato. heey pramukhyane myeloid peshinvar aanee andakoshanvar aanee bhrunjanan honyachya agadi suruvatichya tappyanvar dekhil vyakt hote. see. dii. see. 2 mhanoon olakhalya jaananya see. dii. 1. see. + dendritic peshi upasamuhache chinhak mhanoon see. ell. see. 10aii. chaa vapar keela jaato. legand aanee vatavarananusar see. ell. see. 10aii. chya kriya vaividhyapurn asatat.
karya.
samanyatah, see-prakarchi lectins samanyatah see. aii. 2 + chya upasthitit karbodkanshachya sandhe bandhatat aanee peshi sanlagnata, peshi-peshi sanket, glycoproteinchi uladhal aanee jaljal aanee rogpratikarak pratisadatil bhoomika yasarkhi vividh karye karatat.
clake10aii heey eka prakar II transmembrane prathine aahe (padadyamadhun ekada jaate aanee aine terminuschya aateel dishene jaate) jeey legandchya bandhananantar endocytosisla pravrutt karate. endosome legand sodanyasathi, sahbhagi see. aii. 2 + aayan pratham unbound asane aavashyak aahe. yamule cytoplasmic see. aii. 2 + sandratet lakshaniy vaadh hote.
clake10aii heey 'aine'-acetylgalectosamine (galnack) laa sarvat adhik ghattapane bandhate, beeta-galnackpecsha α-galnackla pradhanya dete, aparivartit galactose atishay kamkuvatpane bandhala jaato. clake10aii heey manvi rogpratikarak pranalitil ekmev see-prakarche lectin aahe jeey keval antim galnackla olakhate. yamadhye tii. aine. pratijan (galnack oo-baddh serine kinwa threonin) samavisht aahe, jeey karsinomvar thalakpane vyakt kele jaate, jithe teey cylilated dekhil kele jaau shakate. hii gaath-sambandhit pratijan (neuro5aca2,6-tn aanee neuroxia2,6-tn) dekhil bandhaleli aahet.
clake10aii heey staphylococcus aurius peshi bhintichya tekoik aamlamadhye aanee parajivinchya prushthbhagavar galnackla bandhatana dekhil disun aale aahe.
clake10aii heey dendritic peshindware vyakt kele jaate jeey bharati kelelya monocytespasoon dahak vatavarnamadhye vegale karatat.
see. dii. 45 madhye exon bii madhye tii. aine. pratijan asate. see. dii. 45 madhye 3 mahattvache exon (4,5,6) aahet, jyanna aii, bii, see asey naav denyat aale aahe. yaa exonchya upasthitinusar see. dii. 45 chya samarupanna label kele jaate. udaharanarth, clake10aii heey see. dii. 45 aar. bii. kinwa see. dii. 45 aar. laa bandhu shakate, jeey see. dii. 45. aar. bii. see. sathee laghulipi aahe. bandhanamule tii peshi kriyakalap, apoptosis aanee rogpratikarak shakti qamee hote. tathapi, sakriy tii peshi see. dii. 45 (see. dii. 45. aar. oo., see. dii. 45. aar. aii.) chey lahan samaroop vyakt karatat jyat exon beecha abhav asato.
clake10aii signalingamule dendritic peshinmadhye il-10chey utpadan hote, kahee pramanat intracellular ca2 + ekagrata vadhavun. aay. ell.-10 heey manavanmadhye tayar honare mukhya niyamak aanee dahak-virodhi cytokine aahe. yaulat, intracellular see. aii. 2 + chya qamee sandratemule aay. ell.-12 heey eka dahak-samarthak cytokine tayar hote, jyamule tii. etch. 1 dhruvikaran dekhil hote.
karkarog sanshodhanat, clake10aii abhivyakti jagane sudharate aanee bighadavte asey donhi aadhalale.
pranyanchya namunyanmadhye, clake10aii, emm. jee. ell. 1 madhye orthologchi kamatarata sansarg aanee jastichi jaljal yaa white parinamanshi sambandhit aahe.