mycosis burshijanya padarth

mycosis burshijanya rog, jyala elebert-bazin syndrome kinwa granuloma burshijanya rog mhanoonahi olakhale jaate, haah tvachechya tii-seela lymphomacha sarvat samanya prakar aahe. heey samanyatah tvachevar parinam karate, parantu kalantarane antargat pragati karoo shakate. lakshananmadhye pural, gathee, tvachevaril jakhama aanee khajanari tvacha yancha samavesh hoto.
kaaran aspasht asale taree, bahutek prakarane aanuvanshik nasatat. bahutansh prakarane 20 varshanpeksha jaast vayachya lokanmadhye aahet aanee mahilanpeksha purushanmadhye hii adhik samanya aahe. upcharanchya paryayanmadhye suryaprakashacha sampark, atinil prakash, samyik corticosteroids, chemotherapy aanee radiotherapy yancha samavesh hoto.
itihas.
mycosis burshijanya roganche varnan pahilyanda 1806 madhye french tvacharog tadnya jeane-louis-marqa elebert yanni kele hote. mycosis fungoids' heey naav atishay dishabhul karnare aahe-yacha arth 'mashrumsarkha burshijanya rog' assa hoto. tathapi, haah rog burshijanya sansarg nasoon, too naun-hodgkin lymphomacha eka prakar aahe. yache naav asey thevanyat aale kaaran elebertne gambhir rugna asalelya tvachechya gathiche varnan mashrumsarkhe swaroop asalyache kele aahe.
chinhe aanee lakshane.
mycosis burshijanya roganchi lakshane teen vaidyakeey tappyat vargikrut kelee jaatatah patch tappa, plake tappa aanee tumour tappa. patch stagechi vyakhya vegvegalya aakaranchya sapat, lalsar patchesdware kelee jaate jyat surkutya disu shakatat. gadad tvacha asalelya lokanmadhye dekhil teey pivalya rangache disu shakatat. plekcha tappa mycosis burshijanya padarthanchya patch tappyanantar yeto. lalsar-tapkiri lalsar-tapkiri unchavalelya jakhamanchya upasthitimule heey vaishishtyapurn aahe; gadad tvachechya rangat, falee rakhadi kinwa chandichya rangachya disu shakatat. patch aanee plake donhi tappe mycosis burshijanya rogachya suruvatichya tappyatil manale jaatat. arbudachya tappyat samanyatah mothya aniyamit gathee disatat. gathinmule chehara aanee dokyachya bhagansah sharirachya konatyahi bhagat fike kinwa samanya tvacha vikasit houu shakate.
darshavileli lakshane pragatishil asatat, suruvatichya tappyat jakhama scally patches mhanoon sadar kelya jaatat. nitambansarkhya kvachitach suryachya samparkat samparkat thikani, jakhama jakhama suruvatila sharirachya khodavar vikasit hotat. yaa jakhama kshullak patte mhanoon suru houu shakatat aanee eka dashkaparyant nidan naan jhalelya rahoo shakatat. jakhamanche hypopigmentation (jevha tvacha samanyapeksha halake asate) qamee samanya asate parantu mule, paugandavasthetil aanee/kinwa gadad tvachechya vyaktinmadhye aadhalu shakate.
mycosis burshijanya rogacha pragat tappa gambhir pruritus (khaaj) aanee scalings samanyikrut erythroderma (shariracha bahutek bhag jhakanare laal pural) dware darshavila jaato. khaaj (pruritus) heey mycosis burshijanya rogancha anubhav anubhav lokanche sarvat samanyapane nondavalele lakshan aahe, 88 takke lock pruritasachya vegvegalya tivrateche ahwal detat jeey samanyatah rog jasjasa vadhato tasatase bighadatat. jyanna tivra pruritasacha anubhav yeto teey samanyatah soochit karatat qee tyacha tyanchya jivanachya gunavattevar bhavnik, karyatmak aanee sharirikdrushtya nakaratmak parinam hoto.
mycosis fungoids (emm. eff.) aanee sezari syndrome (ess. ess.) yaa ekach prakarchya karkarogachya tii-lymphocytes sambandhit paristhiti aahet, jyaa suruvatila sharirachya vegvegalya dabyanmadhye vadhatat. ess. ess. peshi pramukhyane raktat aadhaltat, tarr emm. eff. madhye samanyatah tvachecha samavesh asato. emm. eff. chya pragat tappyat, karkarogachya peshi tvachepasun itar avayavanmadhye aanee raktpravahat jaatat; yaa pragatila "leukemic mycosis fungoids", "mycosis fungoidschya aadhiche sezari syndrome" kinwa "duyyam mycosis fungoids" asey mhanatat.
kaaran.
mycosis burshijanya rog haah asamanya asamanya raktapesheenmule (tii-lymphocytes) hoto. yaa asamanya peshinna tvachechya bahya tharat (bahya tvacha) aniyantritpane sthanikikaran aanee prasar karnyas pradhanya asate. asamanya peshinmadhye nantar lasika granthisarkhya itar avayavancha samavesh asoo shakato. asey gruhit dharale jaate qee yaa karkarogachya peshinmadhil anuvanshik utparivartananmule vaadh hote aanee kramvarit kelelya peshinchya mrutyupasoon sutka hote.
yavyatirikt, haah rog rogpratikarak shakticha eka bhag asalelya see. dii. 4 tii. peshinchi eka asamanya abhivyakti aahe. yaa tii peshi tvacheshi sambandhit aahet, mhanje tyaa jaivarasayanik aanee jaivikdrushtya tvacheshi gatishil paddhatine sarvat jaast sambandhit aahet. mycosis burshijanya rog haah tvachechya tii-seela lymphomacha (see. tii. see. ell.) sarvat samanya prakar aahe, parantu see. tii. see. ell. chey itar anek prakar aahet jyancha mycosis burshijanya roganshi kahihi sambandh nahee aanee yaa vikaranvar vegalya paddhatine upchar kele jaatat.
nidan.
nidanasathi anekada vaidyakeey aanee rogshastriy abhyasanche sanyojan aavashyak asate. nidan karane kadhikadhi katheen asate kaaran rogache suruvatiche tappe anekada dahak tvachechya tvachesarkhe asatat (jase qee isab, psoriasis, liken planus, vitiligo aanee chronic cutaneous lupus erythematosus lycanoid dermatoses), tasech itar tvachechya lymphoma. anek biopsychi shifaras kelee jaate, kaaran suruvatichya emm. eff. madhye pramukh sookshm vaishishtye sahasa anupasthit asatat aanee sampoorn nidanasathi clinical aanee hystological abhyasache sanyojan aavashyak asate. shivay, dirgh kalavadhichya upcharanmule biopsyche nishkarsh badaloo shakatat, jyamule itar dahak tvachechya roganpasoon vegale karane katheen hote. balpanatil mycosis burshijanya rog 0.5% teey 7.0% prakarananmadhye aadhaltat. balpanatil emm. eff. chee mahitee maryadit asali taree, 2021 chya paddhatshir punaravalokanat asey disun aale aahe qee balpanatil emm. eff. chya nidanat lakshaniy vilamb hoto jyamule mulachya purvasuchanavar nakaratmak parinam houu shakato. visheshtah, emm. eff. asalelya bahutek balrogatadnyanna suruvatichya tappyatil rog asato.
histology.
khaleel goshtinchya upasthitine tvachechya biopsiver rogache nikash nishchit kele jaatatah
rogachi avastha sudharanyasathi, granthi, rakt aanee antargat avayavanche moolyankan karnyasathi vividh chachanyanche aadesh dile jaau shakatat, parantu bahutek rugnanna rog tvachepurata maryadit asato, jase qee daag (sapat thipke) aanee fike (kinchit unchavalele kinwa 'surkutya' padalele).
paridhiy smear anekada nitambachya peshi darshavel.
staging.
paramparikpane, mycosis burshijanya padarth teen tappyat vibhagale gele aaheth premycotic, mycotic aanee tumour. premycotic tappa vaidyakiyadrushtya erythemates (laal), khaaj, kharuj jakham mhanoon sadar hoto. sukshmadarshak swaroop heey nidanatmak nasate aanee bahya tvachetil soraisiform badalanshi sambandhit dirghakalin anirdisht tvacharogadvare darshavile jaate.
mycotic tappyat, ghuskhorichya plake disatat aanee biopsymadhye tvachemadhye bahuroopi dahak ghuskhori disun yete jyamadhye thodya pramanat apramanik lymphoid peshi asatat. yaa peshi epidermal besal tharavar vaiyaktikaritya ranget ubhe rahoo shakatat. nantarcha shodh jarr spongiosis nasel tarr mycosis burshijanya rogache atyant soochak aahe. arbud avasthemadhye, cerebriform kendrakansah madhyam aakarachya lymphocyteschi daat ghuskhori tvachela vistarte.
yogya upchar aanee purvasoochana nishchit karnyasathi mycosis burshijanya pranyanche achook charan aavashyak aahe. staging heey mycosis fungoids sahkari gatane prastavit kelelya tumour, node, metastasis, rakt (tii. aine. emm. bii.) vargikaranavar aadharit aahe aanee international society phaur cutaneous lymphoma/european organization auph research andd treatment auph cancerne sudharit kele aahe. hii avastha pranali tvachecha sahbhag (tii), lasika granthichi upasthiti (aine), aatadyansambandhi rog (emm) aanee paridhiy raktatil (bii) sezari peshinchi upasthiti tapasate.
mycosis burshijanya rog asalelya bahutek rugnanna tyanchya prarambhik nidanachya velee prarambhik-tappyatil rog (aay. aii.-aay. aay. aii. tappa) asato. prathamik tappyat pramukhyane tvachepurata maryadit asalela rog asalelya lokanmadhye anukool purvasoochana asate. pragat avastha (aay. aay. bii.-aay. vhee. bii.) asalele lock anekada upcharansathi apavartak asatat aanee tyanche purvasuchan pratikool asate. pragat avasthetil rog asalelya lokansathi upchar paryay arbudache oze qamee karnyasathi, rogachya pragatila vilamb karnyasathi aanee jivanacha darja rakhanyasathi tayar kele aahet.
upchar.
mycosis burshijanya rogansathi sarvat samanyatah shifaras kelela pratham-ola upchar mhanje soralen adhik atinil aii (puva therapy). puva hii eka prakasharasayanik chikitsa aahe jyamadhye prakashsanvedanshil aushadh soralenache samyik kinwa tondi prashasana aanee tyanantar atinil kiranotsargachya tvachechya samparkat yene samavisht aahe. mycosis burshijanya roganchya pranaligat upcharanmule anekada pratikar hoto; tyamule pragat rogamadhye atirikt upchar paryay anekada aavashyak asatat.
itar upchar suchavale gele aahet, tathapi, yaa rogasathi prabhavi upchar dhorane olakhanyasathi mothya aanee adhik vyapak sanshodhanachi aavashyakta aahe. suchavalelya upcharanmadhye prakash upcharpaddhati, atinil prakashpaddhati (pramukhyane aine. bii.-yuu. vhee. bii. 312 aine. emm.), samyik steroids, samyik aanee pranaligat chemotherapy, sthanik varvarchya kiranotsargachi upcharpaddhati, histone dactlase avarodhak vorinostat, ekoon tvacheche electron vikiran, photopherasis, pranaligat upcharpaddhati (udaa.jee. retinoids, rexinoids) aanee jaivik upchar (udaa.jee. interference). upchar anekada ektritpane vaparale jaatat. suruvatichya aajarat upcharanchya paryayanmule paryayanmule sambhavya pratikool parinamanmule adhik pranaligat upcharankade jaanyapurvi sthanik aanee tvacha-nirdeshit upcharansah upchar suru karanyachi shifaras kelee jaate. 2010 madhye, yuu.ess. ann aanee aushadh prashasanane naloxone loshansathi anath aushadh padnam dile, jeey tvachechya tii-seela lymphomamadhye pruritasasathi upchar mhanoon vaparale jaanare eka samyik opioid receptor spardhatmak virodhi aahe. mogamulizumab hii see. see. aar. 4 monoclonal pratipinde aahe jee pragati-mukt astitva sudharanyasathi darshavili gelee aahe. punha punha kinwa apavartak mycosis burshijanya kinwa sezari rog asalelya lokanmadhye vaparnyasathi 2018 madhye yuu. ess. eff. dii. aii. neey yala manyata dilee hotee.
mycosis burshijanya rog asalelya lokanvar upchar karnyasathi acetratin kinwa extracorporial photopherasis (eae. see. pii.: eka prakarchi prakashchikitsa) vaparnyache samarthan karnyasathi konatahi purava nahee. puva aanee intralezanal aay. eff. aine.-aii. kinwa puva aanee bexaroteinchya sanyojanachya upcharala samarthan denare konatehi purave naheet.
mule.
mycosis burshijanya rog asalelya praudhansathi aanee mulansathiche upchar anekada paddhatinchya suraksha profilemule bhinn asatat. samanyatah mulansathi naroband yuu. vhee.-bii. manale jaate, tarr yuu. vhee.-aii., mechlorethamine hydrochloride kinwa tondawate vaparale jaanare bexarotein asalele soralen heey sahasa praudhanmadhye vaparale jaate.
purvasoochana.
see. ell. ell. chya vaidyakeey nondi asalelya lokanchya 1999 chya yuu. ess. aadharit abhyasat 5 varshancha sapeksh jaganyacha darr 77 takke aanee 10 varshancha sapeksh jaganyacha darr 69 takke asalyache disun aale. 11 varshannantar, aadhalalela sapeksh jaganyacha darr sumare 66 takke rahila. garib astitva vruddha vay aanee krishnavarniy jatishi sambandhit aahe. itar ling aanee vaivahik darjachya gatanchya tulanet vivahit mahilanche astitva adhik changle asalyache disun aale. mulanmadhye sampoorn rogmukticha darr sumare 30 takke aahe.
mahamarishastra.
vayachya 20 vya varshapurvi mycosis burshijanya padarth disu lagane durmil aahe; keval patch aanee plake rog asalelya lokansathi suruvatiche sarasari vay 45 teey 55 varshe aahe, parantu tumour, erythroderma (laal tvacha) kinwa leukemic form (sezari syndrome) asalelya lokansathi 60 varshanpeksha jaast aahe. vegvegalya abhyasanmadhye nondavalelya vividh vanshik gatanmadhye ghatanet farak asalelya mahilanpeksha purushanmadhye mycosis burshijanya rog adhik samanya aahet. kahee pradeshanni kahee pramanat sthirikaran darshavile asale taree 2000 teey 2020 yaa kalat mycosis burshijanya roganche praman vadhat asalyache disun aale.
sanskruti aanee samaj.
ullekhaneey prakarane.
1995 madhye abhineta shree. tii chey tvacharog tii-seela lymphoma kinwa mycosis fungoidsche nidan jhaale hote. ekada maafee detana tyane yaa yogayogabaddal vinod kelah "tumhi yachee kalpana karoo shakata qaa? majhya navavar asalela karkarog-vaiyaktik karkarog!"
chaar dashake yaa aajarasah rahilyanantar, lokpriy british durchitravani abhineta paul eddington yanche mycosis burshijanya rogane nidhan jhaale.

