
ranolazine

itaranmadhye ranexa yaa brand navane vikale jaanare ranolezine heey hriday sambandhit chhatichya dukhanyavar upchar karnyasathi vaparale jaanare aushadh aahe. samanyatah itar aushadhe apuri asatana tee ekatra vaparali jaatat. purushanpeksha striyanmadhye fayade qamee disatat. teey tondawate ghetale jaate.
samanya dushparinamadhye baddhakoshthata, dokedukhi, malmal aanee chakkar yene yancha samavesh hoto. gambhir dushparinamadhye kyu. tii. dirghkal samavisht asoo shakate. yakrut serosis asalelyanmadhye yacha vapar karanyachi shifaras kelee jaat nahee. heey kase karya karate heey spasht nahee parantu tyat adenosine triphosphate samavisht asoo shakate.
2006 madhye united statesmadhye vaidyakeey vaparasathi ranolazinala manyata denyat aalee. 2020 madhye, 10 lakhanhun adhik prescriptions, heey united statesmadhil 258 weey sarvat samanyatah vihit kelele aushadh hote.
vaidyakeey vapar.
dirghakalin hrudayavikarachya upcharansathi ranolazincha vapar keela jaato. beeta blocker, nitrates, calcium channell blocker, antiplatelet therapy, lipid-qamee karnari therapy, ess inhibitors aanee angiotensin receptor blockers yacha vapar keela jaau shakato. alindatil tantumayata rokhanyasathi dekhil heey prabhavi aahe aanee monotherapy mhanoon tasech aniyamit hrudayache thoke hatalanyasathi vaparlya jaanarya itar aushadhanchya sanyogane yacha abhyas keela gela aahe.
2019 paryant scotlandmadhye tyacha vapar karanyachi shifaras keleli nahee.
matbhed.
ranolazinesathi kahee matbhed tyachya chayapachayashi sambandhit aahet aanee aushadhanchya parasparsanvadantargat tyanche varnan kele jaate. yavyatirikt, vaidyakeey chachanyanmadhye kahee rugnanmadhye ranolazine kyu. tii. antar kinchit vadhavale aanee eff. dii. aii. lablemadhye doctoranna tyanchya rugnanmadhye yaa prabhavapasun savadh rahanyacha ishara asato. yakrutachya nishkriyatechya rachnet kyu. tii. madhyantaravar aushadhacha prabhav vadhato; asha prakare saumya teey gambhir yakrutacha aajaar asalelya vyaktinmadhye too pratibandhit keela jaato.
dushparinam.
chakkar yene (11.5%) aanee baddhakoshthata (10.9%) heey sarvat samanya dushparinam aahet. itar dushparinamadhye dokedukhi aanee malmal yancha samavesh hoto.
aushadhanchya parasparsanvad.
ranolazinache chayapachay pramukhyane sayyap3aii enzymedware hote. cytochrome sayyap2dii6 yaa chayapachay karananya aanakhi eka enzymela dekhil heey pratibandhit karate. yaa karanastav, tyach rugnane vaparlelya ranolazinechya matra aanee tyaa enzymeshee sanvad sadhananya aushadhanche praman samayojit karane aavashyak aahe.
ranolazincha vapar ketoconazole, chlarythromycin aanee nailfinavir yasarkhya aushadhansah keela jaau naye jeey sayyap3aiilaa jordarpane pratibandhit karatat, kinwa sayyap3aii sakriy karananya aushadhansah, jase qee refampin aanee phenobarbital.
diltiazem, verapamil aanee erythromycin yasarkhya madhyam sayyap3aii avarodhak asalelya aushadhansathi, ranolazinchi matra qamee kelee pahije.
sayyap2dii6 dware chayapachay honari aushadhe, jase qee tricyclic antidepressants, ranolegines dilya gelelya qamee matret denyachi aavashyakta asoo shakate.
krutichi yantrana.
vividh voltage-gated soodiyam vahinyanmadhye hriday snayunmadhye kayamswarupi kinwa usheera aatalya soodiyam pravahala ("aay" naa) ranolezine pratibandhit karate. tyaa pravahala pratibandh kelyane antakoshiy calciumchya patalit ghat hote. yamule hriday bhintichya tanatanavat ghat hote, jyamule snayunsathi oxygenchi aavashyakta qamee hote. prushthbhagavaril electrocardiogram ranolazincha kyu. tii. dirghkal prabhav haah "aay" keey. aar. chya pratibandhamule hoto, jyamule nilayatil kriya kshamata vadhate. ranolezine vilambit rectifier pravahavar (herg/"aay" keey. aar. potassium vahinya) tyache parinam dekhil darshavite, teey sahajpane myogenesis uttejit karate, teey pro-auxidant jaljal/oxidative sthitee qamee karate aanee calcium signalling marg sakriy karate.
ranolazine kruticha sambhavya kalavadhi vadhavate, electrocardiography sambandhit kyu. tii. madhyantar dirghkal, "aay" naa karantala avarodhit karate aanee hyperactive "aay" naa karantmule honare calcium overload rokhate, asha prakare teey padada sthir karate aanee uttejana qamee karate.
itihas.
syntex ink. mulat 1985 madhye ranolezine vikasit karnyas suruvat jhaali aanee tevhapasoon 1994 paryant 61 abhyas purn jhaale. tyanantar, tappa 2 abhyas kele gele; tathapi, asey aadhalun aale qee yaa formulationmule aushadhachya puresha plazma sandratet parinam jhaala nahee. yamulech ranolazinache shashvat-prakashan (ess. aar.) sootra tayar jhaale.
rochane 1994 madhye 1996 madhye syntex vikat ghetale, see. vhee. therapeuticsne rochechi upakampani asalelya syntexkadun uttar american aanee european adhikaranna ranolazinecha parwana deela, jyane aushadhacha shodh lavala hota aanee too dusya tappyatil anjaina chachanyandvare vikasit keela hota. 2006 madhye see. vhee. therapeuticsne rochekadoon ranolezinche urvarit jaagtik haqq midavale. 2008 madhye see. vhee. therapeuticsne europe aanee itar kahee deshanmadhye menarinisathi ranolezinsathi vishesh parwana adhikar dile.
2009 madhye gilliodne see. vhee. upcharpaddhati vikat ghetali. 2013 madhye gilliodne asiasah atirikt deshancha samavesh karnyasathi menarinibarobar bhagidaricha vistar keela.
samaj aanee sanskruti.
kayadeshir sthitee.
itar aushadhanvyatirikt dusya kramankacha upchar mhanoon dirghakalin hrudayavikarachya rugnanvar upchar karnyasathi eff. dii. aii. neey janewari 2006 madhye ranolazinala manyata dilee. 2007 madhye, ekte kinwa itar aushadhansah, ranolazinala pahilya-ola upchar karnyasathi label adyayavat karnyat aale. april 2008 madhye ranolazinala european emiyane anjainamadhye vaparnyasathi manyata dilee.
vyavsayik pailu.
gileadware ranolezine tayar kele jaate aanee ranexa mhanoon vikale jaate. gilliodchya varshik utpannachya vivarnanusar, 2016chya chauthya timahit ranexa aanee gilliodche aanakhi eka utpadan, embisamchi ektrit vikri 62.1 kotee dollar hotee.