
paij avarodhak

bett inhibitors haah aushadhancha eka varg aahe joou bromodoman aanee atirikt-terminal motif (bett) prathine bii. aar. dii. 2, bii. aar. dii. 3, bii. aar. dii. 4 aanee bii. aar. dii. tii. chya bromodomenla ulatya paddhatine bandhato aanee bii. tii. prathine aanee acetylated histones aanee pratilekhan ghatakanmadhil prathine-prathine parasparkriya rokhato.
shodh aanee vikas.
1990 chya dashakachya suruvatila yoshitomi pharmaceuticals (aata mitsubishi tanabe farma) yetheel shastradnyanni phenotypic aushadh patalat thynodiazepine bett avarodhak shodhale hote aanee tyanchi dahak-virodhi aanee karkarog-virodhi agents mhanoon kshamata nondavali gelee. oncoathics (2014 madhye mercney vikat ghetale) mitsubishikadun parvanadharak otx-015 aanee 2012 madhye oncologiesathi (clinical trials) pahili bett avarodhak clinical chachani suru kelee.jee. oo. vhee. olakhakartah aine. see. tii. 01713582). jee. ess. keey. aanee resverologics yaa donhidware apolypoprotein aii-aayachya lahan renu prerkansathi phenotypic screenmadhye bett avarodhak dekhil swatantrapane sapadale. 2010 madhye, jeey. kyu. 1 chaa vapar, otx-015 chaa turt-beautyl krutrim purvavarti, nutt midline karsinommadhye inn vitro kriyakalapasaha prakashit karnyat aala. tevhapasoon anek renunche varnan kele gele aahe jeey bett bromodomenna lakshya karnyas saksham aahet.
bett prathinanchya (bii. dii. 1 viruddha bii. dii. 2) pahilya aanee dusya bromodomenmadhye bhedbhav karnyas saksham asalelya bett avarodhakanche varnan kele gele aahe. tathapi, adyap konatyahi bett avarodhakche varnan kele gele nahee jeey bett kutumbatil sadasyanmadhye (bii. aar. dii. 2 viruddha bii. aar. dii. 3 viruddha bii. aar. dii. 4 viruddha bii. aar. dii. tii.) vishvasarhpane farak karoo shakel. keval sanshodhan sandarbhat vaiyaktik bett prathinanna jacque1/aay-bett 762 chya vyutpattisathi adhik sanvedanshil mhanoon utparivartit karoon lakshya kele gele aahe.
krutichi yantrana.
karkarogamadhye bett inhibitors vaparnyat rus yaa nirikshanapasun suru jhaala qee bett januk bii. aar. dii. 3 aanee bii. aar. dii. 4 yancha samavesh asalelya gunasutranchya sthanantaranamule durmil karkarog nutt midline carcinomache rogjanan hote. tyanantarchya sanshodhanat, bett prathine bii. aar. dii. 4 varr tivra myeloid leukemia, multiple myeloma aanee tivra lymphoblastic leukemiache kahee prakar avalambun rahane aanee yaa karkaroganchi bett avarodhkanprati sanvedansheelata ughad jhaali. anek prakarananmadhye, vadhila protsahan denanya pratilekhan ghatakachi abhivyakti, maay. see., hii baji avarodhkadvare avarodhit kelee jaate. bii. aar. dii. 2 aanee bii. aar. dii. 3 heey karyatmakdrushtya anavashyak aahet aanee pratyek bett prathin vaiyaktikaritya qamee karananya abhyasanmadhye kautuk karnyapeksha upcharatmak uddishte mhanoon adhik mahatvache asoo shakatat.
alikadil abhyasanmadhye asehi disun aale aahe qee sanyojan upcharanmadhye vaparlyas itar lakshyit upcharanchya pratikaravar maat karnyasathi bett avarodhak mahattvachi tharoo shakatat. udaharananmadhye tii seela tivra lymphoblastic leukemiyasathi γ-secretage inhibitors bett inhibitorscha vapar aanee braf-inhibitor pratirodhak melanoma, jeey brafvi 600eae utparivartan vahoon netat, tyanchyasathi braf-inhibitor (vemurafenib) yancha samavesh hoto.
vishisht paij avarodhak.
sarvajanik nidhichya sanshodhan prayogshalanni tasech glaxosmithcline, oncoathics (merc andd companyne vikat ghetalelya) yasah aushadhanirman kampanyanni bett avarodhak vikasit kele aahet. 2014 madhye), oncoathics, nakshatr pharmaceuticals, resveralogics corp aanee zenith epigenetics. ullekhaneey paij pratibandhakanmadhye heey samavisht aaheh