smid 3

sanch (vividharangikaran dabnara, zuste, trithorax vadhavnara) aanee mind (myeloid-nerve-dafe-1) domain-yukt prathine 3 hii eka prathine aahe jee manavanmadhye "smide 3" janukadware encode kelee jaate.
karya.
smide 3 haah eka lycine methyltransferase aahe joou visheshtah visheshtah aanee aanee methylate karato. aahe rna polymerase complexcha sadasya mhanoon pratilekhan niyamanat bhoomika bajavate. karkarogachya niyantranat dekhil yacha samavesh aahe.
abhivyakti.
smide 3 pramukhyane hadanchya snayunmadhye aanee vrushananmadhye vyakt hote.
jivanche pratikruti.
aahe karyachya abhyasat pratikruti jivancha vapar keela gela aahe. velakam trust sanger institutemadhye, aantarrashtriy nockout maus consortium karyakramacha bhag mhanoon mhanoon (comp) wtci' navachi sashart nockout maus line tayar karnyat aalee hotee-rus asalelya shastradnyanna rogache prani model tayar karnyasathi aanee vitarit karnyasathi eka uchch-thruput mutagenesis prakalp.
hatavanyache parinam nirdharit karnyasathi narr aanee maadee pranyanna pramanit phenotypic screen dilee gelee. samaroop utparivarti praudh undaranvar tevis chachanya karnyat aalya, matra konatihi lakshaniy vikrutee aadhalali nahee.
parasparsanvad.
aahe haah ushmashka prathine 90kda alfa (cytosolic), sadasya aii1 aanee aanee yanchyashi parasparkriya karato asey disun aale aahe.
aahe heey heey varr lycine avashesh trimethyl karate, jyamule raas-chalit karkaroganmadhye nakashatil kinage signalling margamadhye crosstock hoto.
karkarogashi sambandh.
manavanmadhye karkarogachya pragatimadhye ess. emm. aay. dii. 3 mahatvachi bhoomika bajavate. yakrut, stun aanee colorectal carcinoma yasarkhya anek karkaroganmadhye heey khoop jaast vyakt hote. smide 3 fuffus, annanalikechya aanee prostate karkaroganmadhye dekhil bhoomika bajavate.
heey nondavale gele aahe qee fuffus aanee colorectal karkaroganmadhye, smide 3 dware mapp mapp 2 methylationmule pii. pii. aii. 2 chey pratibandhatmak niyantran sudharate, jyamule meek/aii. aar. keey. signalling cascade sakriy karoon apoptosis signalche adhirohan hote. darmyan, bruhadantra aanee yakrutachya karkarogamadhye, karkarogamadhye aahe-madhyasthi methylation methylation bharati aanee proto-oncogenic pradeshanmadhil sambandhit pratilekhan ghatakanna protsahan dete.

