ekadhik electrode samuchchay

multiple electrode aggregometry (emm. eae. aii.) hii sampoorn raktatil plateletchya karyachi chachani aahe. yaa chachanicha vapar platelet vikaranche nidan karnyasathi, antiplatelet therapyche nirikshan karnyasathi keela jaau shakato aanee hriday shastrakriyetil sankraman aavashyakta aanee raktastrav honyachya jokhamicha sambhavya andaj lavnara mhanoon dekhil tapas keela jaato.
vadya.
multiplate mea vishleshkamadhye (roche diagnostics international limited) anek namune kinwa agonistschya ekach velee mojmap karnyasathi 5 marg aahet. chachani kyuvetmadhye dhatuchya electrodavar platelets ektrit hotat tevha vidyut pratibadha badal shodhate. pratyek kuvetmadhye sanvedak electrodechya done jodya asatat, jyapaiki pratyek pratibadha badal mojate. duplicate sensors ekatmik gunavatta niyantran mhanoon kaam karatat aanee mojmapanmadhil parasparsambandh gunank 0.98 peksha jaast asalyas vishleshan sweekarle jaate. pratyek vakr aanee sarasari vakramadhil farak dekhil mojala jaato aanee 20 takkyanpeksha qamee farak swikarla jaato. chachani covetmadhye teflon lepit chumbakeey halvinari patti dekhil asate. ektrikaran hott asatana pratibadha vadhanyache ektrikaran ekkanmadhye (aii. yuu.) rupantar hote aanee sanganakachya patalavar velechya viruddha rachale jaate.
namuna.
chachanisathi namunyansathi anticoagulant mhanoon hirudin vaparanyachi utpadak shifaras karato, parantu abhyasatoon asey disun aale aahe qee heprin haah eka changla paryay aahe. pratyek vishleshanasathi 300 microll rakt aavashyak asate aanee teey samaan pramanat ksharyukt karoon patal kele jaate. rakt aanee kharat padarth kuvhetmadhye pipe karoon ghetalyanantar, nivadalela agonist jodanyapurvi chachani teen minite ubavali jaate. tyanantar chachani suru kelee jaate aanee sahaa minitansathi andaje 0.5 sekandanchya antarane platelet ektrikaran nondavale jaate. teen mapdand mojale jaatatah ektrikaran, veg aanee vakr (aii. yuu. see.) antargat kshetra. ektrikaran (aii. yuu. madhye) hii ektrikaran vakrareshechi kamal unchi aahe aanee veg (aii. yuu./minitat) haah vakrareshecha kamal utaar aahe. aii. yuu. see. haah sarvat mahattvacha mapdand aahe. heey ekkanmadhye (yuu) nondavale jaate aanee ektrikaran vakrareshechi unchi aanee utaar yaa donhinni prabhavit hote aanee heey platelet kriyakalapanche sarvottam ekoon mojmap aahe.
chachanya/abhikarmak gunakar qaraa.
sarvat yogya.
adenosine diaphosphate (aii. dii. pii.) haah platelet agonist aahe. jevha teey chachani kyuvetmadhye ksharyukt-patal sampoorn raktat misalale jaate, tevha teey plateletsvaril aii. dii. pii. receptorsna uttejit karate, platelets sakriy karate. plateletschya sakriyatemule aakar badalato aanee apghatan hote aanee danyanmadhun mukt honari samagri plateletsla aanakhi sakriy karate. sakriyakaranamule glycoprotein aay. aay. bii./aay. aay. aii. (jee. pii. aay. aay. bii./aay. aay. aii.) receptormadhye sanrachanatmak badal dekhil hoto, jyamule tyala fibrinogenshy uchch sambandh midato. jee. pii. aay. bii./aay. aay. aii. receptors fibrinogenche bandhan platelet-teey-platelet poolmadhye jaate aanee parinami platelet ektrikaran hote. clopidogrel aanee prasugrelsarkhi plateletvirodhi aushadhe aii. dii. pii. receptor pii. pii. 12 laa aparivartaniyapane pratibandhit karatat, jyamule aii. dii. pii.-prerit platelet ektrikaran qamee hote. jee. pii. aay. bii./aay. aay. aii. receptorla pratibandh karnari aushadhe, udaa.jee. aii. dii. pii.-prerit platelet pratisad dekhil aii. pii. tii. fibatoid qamee karoo kinwa kadhoon takoo shakate.
atishayshayi.
espitestmadhye arakidonic aaml ksharyukt-patal rakt namunyat misalale jaate. cyclooxigenase-1 (see. oo. ex. 1) dware erakidonic aaml prostaglandin prostaglandin (pii. jee. etch. 2) madhye rupantarit kele jaate aanee pii. jee. etch. 2 nantar thromboxen synthesdware thromboxen aii2 (tii. ex. aii. 2) madhye rupantarit kele jaate. sakriyak platelet ektrikaran vadhavate, apghatanas protsahan dete aanee platelet sakriyan uttejit karate. acetylsalycylic esidpramanech cocks 1 chey pratibandh aanee glanzmanchya thrombastheniamadhye disalyapramane jee. pii. aay. bii./aay. aay. aay. aii. receptorche pratibandh kinwa anupasthiti, erakidonic acidla pratisad mhanoon plateletche ektrikaran qamee karel.
coultest.
sample-saline mishranat collegen misalale jaate aanee plateletsvaril collegen-receptors bandhale jaate. yamule erakidonic aaml sodale jaate, jeey shaktishali platelet sakriyak sakriyak madhye rupantarit hote. coultest heey cocks 1 aanee gpib/iiachya pratibandhasathi aanee glanzmanchya thrombastheniasathy sanvedanshil asate.
restotust.
restocetin wonn willebrand factor (vhee. doubleu. eff.) saha sankul tayar karate jeey plateletsvaril glycoprotein aay. bii. (jee. pii. 1. bii.) receptors bandhale jaatat, jyamule platelet sakriy hotat aanee ektrikaran hote. 
wonn willebrand rogamadhye (vhee. doubleu. dii.) disalyapramane, restocetinchya pratisadat qamee kinwa anupasthit ektrikaran heey vhee. doubleu. eff. chya kamataratemule kinwa qamee jhalyamule kinwa bernard-solier syndromedhye (bii. ess. ess.) disalyapramane jee. pii. 1. bii. receptorschya sankhyet gairhajeri kinwa ghat jhalyamule houu shakate.
restotest done sandratemadhye kele jaau shakate; ristohai aanee ristolo. restohymadhye, 0,77 mii. gra./miilii. chey restocetinche praman lagoo kele jaate. heey samanyatah eka majboot platelet ektrikaranas pravrutt karate aanee qamee kinwa anupasthit ektrikaran heey aadhi namood kelelya sthitee wheedbludy aanee bssmule houu shakate. restolomadhye, restocetinche praman fakt 0,2 migra/miilii asate aanee asha patalivar jeey samanyatah majboot ektrikaran pratisad dett nahee. hii chachani heey shodhu shakate qee vhee. doubleu. eff. madhye platelets ektrit karanyachi samanya pravruttipeksha jaast majboot aahe qee nahee, jee vhee. doubleu. dii. aay. bii. navachya vhee. doubleu. dii. chya upprakarat pahili jaau shakate.
sarvat trapt.
thrombin receptor peptide-6 (trap-6) sakriy karnara thrombin receptor protease sakriy receptor-1 (paar-1) dware platelets sakriy karato. trap-6 teey teey bandhanimule plateletsvaril jee. pii. aay. bii./aay. aay. aii. receptorsmadhye sanrachanatmak badal hoto, jyamule tyanna fibrinogenshy uchch sambandh midato. tyanantar fibrinogen receptors bandhale jaate, anek plateletsla cross link karate aanee ektrikaran karate. glanzmanchya thrombastheniamadhye, jethe jee. pii. aay. bii./aay. aay. aii. receptors qamee kinwa anupasthit asatat, kinwa jarr rugna jee. pii. aay. bii./aay. aay. aii. virodhi ghet asel, tarr traptestmadhil ektrikaran qamee kinwa anupasthit asoo shakate. traptestmadhye see. oo. ex. 1 aanee aii. dii. pii.-receptorschya pratibandhasathi keval kirkol sanvedansheelata asate.
aasa abhikarmak.
raktachya namunyat aasa (acetylsalycylic acid) abhikarmak misalalyane espitst aanee coltestmadhil ektrikaran pratisad qamee hoto. aii. ess. aii. plateletsmadhye cocks 1 laa aparivartaniyapane pratibandhit karate, jyamule tii. ex. aii. 2 chey utpadan pratibandhit hote. aii. ess. aii. abhikarmak gunakarasah platelet karya chachanimadhye gunavatta niyantran mhanoon vaparla jaato, jyamule espitest aanee coltestmadhye asamanya platelet pratisadanche moolyankan karata yete.
jee. pii. aay. bii./aay. aay. aii. virodhi abhikarmak.
gunakar platelet karya chachanimadhye gunavatta niyantran mhanoon yaa abhikarmakacha vapar keela jaato. jee. pii. aay. bii./aay. aay. aii. virodhi jee. pii. aay. bii./aay. aay. aii. receptors fibrinogenche bandhan avarodhit karate, jyamule platelet-fibrinogen bandh tayar honyas pratibandh hoto aanee parinami serve agonistschya pratisadat platelet ektrikaran lakshaniyaritya qamee hote. virodhi abhikarmak sapala-chachanisah ekatra vaparla jaato aanee sakaratmak niyantranache moolyankan karnyas anumati deto.
prostaglandin eae1 abhikarmak.
prostaglandin eae1 (pii. jee. eae. 1) haah eka platelet avarodhak aahe jyamule edenilil cyclays kriyakalap uttejit karoon plateletsmadhye chakriy adenosine monofosphate (camp) vaadh hote. camp haah eka antahkoshikiy sanket renu aahe aanee campmadheel vaadh aii. dii. pii. receptor pii. pii. 1 chya sakriyatemule prerit calciumchi jamavat aanee platelet ektrikaran rokhate. pii. pii. 1 receptor sakriy kelyane aii. dii. pii. chya pratisadat platelet ektrikaran suru hote. aii. dii. pii.-prerit platelet sakriyatesathi pii. pii. 1 receptor aavashyak aahe, parantu aii. dii. pii. chya pratisadat sampoorn platelet ektrikaranasathi purese nahee.
shibir platelet ektrikaran rokhate aanee plateletmadhil campche praman qamee jhalyamule platelet ektrikaran hote. 
pii. jee. eae. 1 abhikarmak aii. dii. pii. chachanisah done karanansathi ekatra vaparla jaatoh aii. dii. pii. uchch sanvedanshilateche (etch. ess.) moolyankan aanee aii. dii. pii. chya sakaratmak niyantranache. 
jevha yogyatemadhye thodese pii. jee. eae. 1 (20 maay. lii.) jodale jaate, tevha teey samanya namunyanmadhye ektrikaranas madhyam pratibandh karate, parantu clopidogreldware pratibandh karnyasathi plateletschi sanvedansheelata mothya pramanat vadhavate. mhanunach sudharit chachanila "uchch sanvedansheelata" mhanatat.
sarvat yogya thikani 50 microll pii. jee. eae. 1 jodalyane aii. dii. pii. prerit ektrikaranala jordar pratibandh hoto aanee tyacha vapar yogya thikani sakaratmak niyantrananchya mulyankanasathi keela jaato.

