aar. aar. tii. 2

mitochondrial roow jee. tii. paces. 2 heey eka enzyme aahe jeey manavanmadhye manavanmadhye janukadware encode kele jaate. myro prathin isophorm mhanoon, prathine mitochondria motor/adaptor complexeshy jodoon mitochondrial vahtook sulabh karatat. mitochondrial vahatukitil tyachya pramukh bhoomikedware, aar. aar. tii. 2 haah mitochondrial homeostasis aanee apoptosis, tasech parkinson rogamadhye (pii. dii.) sameel aahe.
rachana.
sastan pranyanmadhye, rott 2 heey done myro samarupanpaiki eka aahe. donhi samarupanmadhye done jee. tii. pii.-bandhan kshetranna kshetranna done eae. eff.-hand motifschee rachana asate aanee eka see-terminal transmembrane kshetra jeey prathinanna bahya mitochondrial patlala (oo. emm. emm.) jodate. eae. eff.-hand motif heey adaptor prathine milton aanee kinesine judd sakhalisathi bandhan sthal mhanoon kaam karatat. hii kshetre calcium aayanana dekhil bandhu shakatat aanee bandhanimule sanrachanatmak badal hoto jyamule mitochondrial prushthbhag kinesinpasoon vegala hoto.
karya.
rhot2 haah rho gtpase kutumbatil eka sadasya aahe aanee protein mirochya done samarupanpaiki eka aaheh rhot1 (miro1) aanee rhot2 (miro2). roow jee. tii. paces kutumbatil urvarit lokanchya tulanet, tyanchya bhinn niyamnamule, miro samarupata hii asamanya manali jaate. shivay, myro isophorm keval mitochondriamadhye vyakt kele jaatat.
mitochondrial motor/adaptor complexes tayar karnyasathi miro haah milton (track 1/2) aanee motor prathine kinesin aanee dyninshee jodala jaato. myro heey sankul mitochondrianmadhye pathvanyasathi karya karate tarr complexes peshinmadhil microtubulesdwar mitochondrianchi vahtook karate. jaree mirocha pramukhyane neuronsmadhye abhyas keela gela asala, taree lymphocytesmadhil mitochondria sooj jhalelya endotheliakade nenyat sahbhagi honyasathi prathine dekhil aadhalali aahet.
motor/adaptor complexes calcium aayanchya patalidvare niyantrit kele jaate. uchch sandratemadhye, calcium aayan mitochondrial vahtook mirola bandhun rokhatat, jyamule complexes organelpasoon vegale hote. dendritesmadhil glutamate receptorsche sakriyakaran, akshatantunmadhil krutee kshamata aanee neuromodulator yasarkhe sharirik ghatak calcium aayanchi patali vadhavu shakatat heey lakshat gheta, hii niyamak yantrana calcium aayan buffering aanee sakriy niryat pradan karnyasathi asha bhagat mitochondria rakhanyasathi aanee asha prakare, homeostasis rakhanyasathi kaam karate.
yavyatirikt, mitofucine sanyogane mitochondrial fusion aanee mitophagyche niyaman myro karate. eka pratimananusar, kharab jhalele mitochondria heey nirogi mitochondriapasoon myro aanee mitofucine mitofucine vegale kele jaatat. myro degradationmule tyanchi halchal thambate tarr mitofucin degradation tyanna nirogi mitochondriashy misalanyapasun rokhate, asha prakare autofagosomsdware tyanchi safsafai sulabh hote. 
vaidyakeey mahatva.
abhyas asey darshavtat qee myro haah pidimadhye samavisht asoo shakato. neuronsmadhye, miro pii. dii. madhye samavisht asalelya done pramukh prathinanshi sanvad sadhato, gulabi 1 aanee parkin. mitochondria vidhruvikaranantar, vidhruvikaranantar anek thikani gulabi 1 phosphorylates miro aanee parkin sarvavyapi miro, protesomal ksharanasathi lakshya karate. miroche vighatan nantar mitochondrial vahtook thambavate.
jaree roow jee. tii. paces kutumb karkarogachya pragatishi jawalun sambandhit asale, taree asamanya myro prathinanshi assa sambandh darshavinare kahee abhyas aahet.
parasparsanvad.
rhot1 saha sanvad sadhatana dakhavale gele aaheh

