
paak 1

serine/threonin-prathine keynage paak 1 heey eka enzyme aahe jeey manavanmadhye "paak 1" janukadware encode kele jaate.
paak 1 haah serine/threonine kinesesachya paak kutumbatil sahaa sadasyanpaiki eka aahe, jeey vyapakpane gut I (paak 1, paak 2 aanee paak 3) aanee gut II (paak 4, paak 6 aanee paak 5/7) madhye vibhagale gele aahet. paak utkrantivadi paddhatine sanrakshit kele jaatat. paak1 heey peshidravya aanee kendrakamadhil vishisht up-koshikeey kshetranmadhye sthanbaddh hote. paak1 cytoskeletonche nutanikaran, phenotypic signalling aanee januk abhivyakti niyantrit karate aanee dishatmak gatishilata, aakraman, metastasis, vaadh, peshi chakr pragati, angiogenesis yasarkhya vividh prakarchya pesheey prakriyanvar parinam karate. paak 1-signalvar avalambun asaleli cellular karye karkarogasah sharirik aanee rog prakriya donhi niyantrit karatat, kaaran paak 1 mothya pramanat manvi karkarogamadhye atiprabhavit aanee atisanvedanshil aahe.
shodh.
1994 madhye mancer aanee sahakanyanni undaranchya mendutil roow jee. tii. pesesacha parinamkarak mhanoon paak 1 pahilyanda shodhala. neutrofilschya cytosolic anshamadhye aar. aii. see. 1 kinwa see. dii. see. 42 chaa jee. tii. pii.-aadharit parasparsanvadi bhagidar mhanoon manvi paak 1 olakhala gela aanee 1995 madhye martin aanee sahakanyanni manvi naal granthalayatun tyache purak dii. aine. aii. pratirupan kele.
karya.
paak prathine heey jee. tii. paces. chya (aar. jee. tii. paces.) aar. oo. kutumbala cytoskeleton punarrachana aanee anoo sanketanshi jodanare mahattvapoorn parinamkarak aahet. serine/threonin pii21-sakriy kaynesesachya eka kutumbatil paak prathinanmadhye paak1, paak2, paak3 aanee paak4 yancha samavesh hoto. hii prathine see. dii. see. 42 aanee rack yaa lahan jee. tii. pii. bandhan prathinansathi lakshya mhanoon kaam karatat aanee vividh prakarchya jaivik kriyakalapanmadhye guntaleli aahet. pii. aii. keey. 1 peshinchi gatishilata aanee aakarvidnyan niyantrit karate. yaa janukachi paryayi pratilekhan sapadali aahe, parantu tyanche purn lambiche swaroop nishchit kele gele nahee.
paak 1 kriyakalapanchya uttejanasobat pesheey prakriyanchi eka malika asate jee jiwant pranalinsathi moolbhut aahe. nodular signalling renu asalyane, paak 1 peshinchya prushthbhagavaril prathinandware tasech varchya bajus sakriyakartyandvare suru jhalelya mothya sankhyene sanketanchya abhisaran kendrasathi karya karate aanee vishisht phenotypesmadhye rupantarit hote. jaivarasayanik staravar, yaa kriyakalapanche niyaman paak 1 chya tyachya prabhavak parasparsanvadi tharanna phosphorylate karnyachya kshamatedvare kele jaate, jeey tyaa badalyat pesheey phenotypic pratisadat ektrit honanya jaivarasayanik ghatanancha eka pravah tayar karatat. yavyatirikt, paak 1 krutee dekhil tyachya farshi kriyakalap prabhavit aahe. paak 1-niyantrit pesheey prakriyanchya udaharananmadhye actin aanee microtubule tantunche gatishil, peshi chakrachya pragatidarmyanachi mahattvapoorn pavale, gatishilata aanee aakraman, redox aanee urja chayapachay, peshiche astitva, angiogenesis, dna-durusti, samprerak sanvedansheelata aanee januk abhivyakti yancha samavesh hoto. paak 1 signalingache karyatmak parinam oncogenesis, vishanujanya rogjanan, hriday v raktavahinyasambandhi aniyamitata aanee majjasansthesambandhi vikaranmadhil tyachya bhoomikedware darshavile jaatat.
januk aanee vibhajit prakar.
manvi paak 1 januk 153-keey. bii. lamb aahe aanee tyat 23 exon, 5 '-yutarsathi sahaa exon aanee prathine kodingsathi 17 exon asatat (punaravalokanatun januk). sahaa exonche paryayi vibhajan 308-bii. pii. teey 3.7-kb paryant 20 pratilekhan tayar karate; tathapi, keval 12 pratilekhananmadhye vachan chaukat khulee asate aanee tyat daha prathine aanee done polypeptides code hotil assa andaj aahe. urvarit 8 pratilekhanchi shreni 308-bii. pii. teey 863-bii. pii. paryantchya naun-coding lamb aar. aine. aii. sathee aahe. manvi paak 1 chya ulat, murine paak 1 januk paach pratilekhe tayar karateh 508-bii. pii. pasoon 3.0-kb paryant teen prathine-coding aanee naun-coding aar. aine. aii. sathee sumare 900-bii. pii. chee done pratilekhan.
prathinanche kshetra.
paak kutumbachya mukhya kshetranmadhye see-terminal pradeshatil kinez kshetra, pii 21-binding kshetra (pii. bii. dii.) aanee gut 1 pakmadhil swayam-avarodhak kshetra (madat) yancha samavesh hoto. gut I paak heey nishkriy, bund samaroop rachnet astitvat asatat jyamadhye eka renuchi madat dusya renuchya keynage kshetrashi bandhali jaate aanee jee. tii. paces-aadharit aanee swatantra asha donhi prakare sakriy hote.
sakriyakaran/pratibandh.
paak1 madhye eka autoehibitory domain aahe jeey tyachya keynage domenchya utprerak kriyakalapanna dadapate. paak1 sakriyak heey svayamrodhikaran door karatat aanee sanrachanatmak punarrachana aanee autophosphorylation ghatana suru karatat jyamule keynage sakriy hote.
aay. pii. aii.-3 (1,1′-dysulfenedinafthalen-2-oo. ell.) haah paak 1 chaa eka lahan renu allosteric avarodhak aahe. purv-sakriy paak 1 haah aay. pii. aii.-3 laa pratirodhak aahe. jiwant peshinmadhil pratibandh haah pii. dii. jee. eff.-uttejit aii. aar. keey. sakriyakaranat paksathi mahattvapoorn bhoomika bajavato. aay. pii. aii.-3 chey pii. aii. keey. 1 niyamak kshetrashi ulat karata yenyajoge sahsanyojak bandhan heey jee. tii. paces. docking aanee tyanantar utprerak mhanoon sakriy sthiteet jaanyapasun rokhate.
prostate karkarogachya peshinmadhil paak 1 nockdown qamee gatishilata, qamee emm. emm. pii. 9 srav aanee vadhiv tii. jee. eff. bii. tii. abhivyaktishi sambandhit aahe, jeey yaa prakarananmadhye vaadh pratibandhak aahe. tathapi, sulfhydrilchya bhagachya satat ghatanyamule aay. pii. aii.-3 chey pharmacokinetic gunadharm tasech peshinmadhil avanchhit redox prabhav, teey vaidyakeey vikasasathi ayogya banavtat.
varchya bajula sakriy karnare.
paak 1 kriyakalap mothya sankhyene varchya bajus sakriy karnare aanee sanketandware uttejit hoto, jyat eae. jee. eff., hergulin-beeta 1, vejaf, moolbhut fibroblast vaadh ghatak, platelet-vyutpann vaadh ghatak, astrogen, lysophosphatidic acid, phosphoenositides, ityadi, eketi, jeeck 2, erk, kesin kinez II, rack 3, kemokin (see-ex-see motif) ligand 1, stanacha karkarog-virodhi astrogen pratirodh 3, kaposicha sarcoma-sambandhit herpesvirus-jee prathine-jodalele receptor, aarg-binding protein 2 jee, hepatitis bii vishanu ex protein, stay 20-sambandhit keynage adaptor protein α, royee, kothlos, nothlossy, eka prophylacomino-cases, aanee 2-interactin-cases, philacomino-transfer, eka proteins-intractin, 2-interactin-philacomino-cases, 2-interactin
downstream prabhavak uddishte.
paak 1 chee karye phosphorylate downstream effector substrates, scaffold kriyakalap, vishisht up-cellular cellular up-domenmadhye punarvitaran, tyachya genomic lakshyanchya abhivyaktiche uttejan kinwa dadapshahi pratyaksh kinwa apratyakshapane kinwa yaa serve yantranedvare niyantrit kelee jaatat. karkarogachya peshinmadhil pratinidhi paak 1 prabhavak ghatakanmadhye heey samavisht aaheh stathmin-ess 16, merlyn-ess 518, vimentin-ess 25-ess 38-ess 50-ess 65-ess 72, histone etch 3-ess 10, philamina-ess 2152, astrogen receptor-alfa-ess 305, signal transducer aanee pratilekhan 5aii-ess 779 chey sakriyak, see-terminal binding protein 1-ess 158, rf 1 ess 338, rpc 1 bii-tii 21, dlc 1 ess 88, phosphoglucommutase 1-tii 466, smart/hdac 1 sambandhit repressor protein-ess 3486-tii 3568, tubulin cofactor bii-ess 65-ess 128, snell-ess 76 end vithals, ndad-76, ndad-76, ndad-76, ndad-76, ndad-76, ndad-76, ndad-76, ndad-76, nda-76, nda-76, nda-76, aine
janukeey uddishte.
paak1 aanee/kinwa paak1-aadharit sanket tyachya janukeey lakshyanchya abhivyaktimadhye badal karatat, jyat raktavahinyanchya endothelial vadhicha ghatak, cycline dii1, phosphophructokines-snayu isophorm, sakriy tii-peshicha anoo ghatak, cycline bii1, ootee ghatak aanee ootee ghatak marg avarodhak, metalloproteinez 9 aanee fibronectin yancha samavesh aahe.
parasparsanvad.
paak 1 yachyashi sanvad sadhatana dakhavale gele aaheh