
ethosuximide

itaranmadhye zarontin yaa brand navane vikale jaanare ethosuximide heey eka aushadh aahe jeey anupasthititil zatkyanvar upchar karnyasathi vaparale jaate. heey swatah kinwa valproic esidsarkhya itar anticiser aushadhansah vaparale jaau shakate. ethosuximide tondane ghetale jaate.
ethosuximide samanyatah changlya prakare sahan kele jaate. samanya dushparinamadhye bhook naan lagane, otipotat dukhane, atisar aanee thakwa jaanavane yancha samavesh hoto. gambhir dushparinamadhye aatmahatyeche vichar, rakt peshinchi patali qamee hone aanee lupus erythematosus yancha samavesh hoto. garbhadharanedarmyan garbhavar yacha pratikool parinam hoto qee nahee heey spasht nahee. ethosuximide heey aushadhanchya sukinimide kutumbatil aahe. tyachi krutichi yantrana postsyneptic tii-prakarchya voltage-gated calcium vahinichya vaimansyamule asalyache manale jaate.
1960 madhye americet vaidyakeey vaparasathi ethosuximidela manyata denyat aalee. too jaagtik aarogya sanghatanechya aavashyak aushadhanchya yadeet aahe. ethosuximide heey samanya aushadh mhanoon upalabdh aahe. 2019 paryant, americet kimmat nishchit karnyachya chintemule anek deshanmadhye tyachi upalabdhata maryadit hotee.
vaidyakeey vapar.
heey anupasthititil japtisathi manjur aahe. anupasthitit honanya zatkyanvar upchar karnyasathi ethosuximide heey pratham pasantiche aushadh manale jaate kaaran tyat paryayi anupasthitit asalelya aushadh, valproic aesidchya vishisht hepatotoxicitycha abhav aahe.
pratikool parinam.
itar anticonvalsantpramanach, ethosuximidemadhye garbhadharanedarmyan vapar karnyababat ishara asato. jaree janmajat doshanshi karanatmak sambandh prasthapit jhalela nasla taree, lahanse daurehi aalelyanna aaimule honanya dnyat hanichya tulanet balala haanee pohochavanyachi shakyata mojali jaate.
rakt.
"asthimajja nasht jhalyavar kinwa naan jhalyas khaleel goshti houu shakatatah"
aushadhanchya parasparsanvad.
valprotes ektar ethosuximidechi patali qamee kinwa vadhavu shakatat; tathapi, valprotes aanee ethosuximidechya sanyogat ektya aushadhapeksha adhik snrakshak nirdeshank hota.
yamule seeram phenitoinchi patali vadhu shakate.
krutichi yantrana.
jyaa yantranedvare ethosuximide majjatantuchya uttejanavar parinam karate tyamadhye tii-prakarchya calcium vahinyancha khand samavisht asato aanee tyat aayan vahinyanchya itar varganvar aushadhache parinam samavisht asoo shakatat. ethosuximide haah tii-prakarcha calcium vahini avarodhak aahe yaa prathamik shodhala vyapak pathimba midala, parantu shodhachi nakkal karnyache prarambhik prayatna visangat hote. peshi reshanmadhil punarsanyojit tii-prakarchya vahinyanvaril tyanantarchya prayoganni heey nirnayakpane dakhavun dile qee ethosuximide serve tii-prakarchya calcium vahinyanchya samarupanna avarodhit karate. tii-prakarchya calcium vahinichi lakshaniy ghanata neuronschya dendritesmadhye aadhalate aanee tii-prakarchya calcium vahinyanchya yaa dendritic strotapasun door jaananya qamee tayaritoon nondavalelya nondimule ethosuximidechya akaryakshamatechya ahavalat yogdan dile asave.
march 1989 madhye, coulter, hugenard aanee prince yanni dakhavun dile qee ethosuximide aanee diamethadione, donhi prabhavi anty-ebuns agents, navyane kadhoon takalelya thalamic neuronsmadhye tii-prakarchya calcium vahinyanmadhil qamee-maryada ca2 + pravah qamee karatat. tyach varshi junmadhye, tyanna hii ghat karanyachi yantrana voltage-aadharit asalyache aadhalale, jyat under aanee giinii dukaranchya tivrapane vighatit neuronscha vapar keela gela; asehi nondavale gele qee, japtichya anupasthitit dekhil vaparale jaanare valproke acid asey karat nahee. pudhchya varshi, tyanni dakhavun dile qee anticonvalsant sukinimidesney heey kele aanee pro-convalsantne tase kele nahee. pahilya bhagala coastuke aanee itaranni pathimba deela hota. 1992 madhye, jyanni 7 micronol/ell teey 1 emm. emm. oo. ell/ell. paryantchya sandratemadhye prushthiy mool gangliatil pravahat lakshaniy ghat nondavali.
tyach varshi, tathapi, herrington aanee lingala 2.5 mimeol/ell paryantchya sandratevar assa konatahi parinam aadhalala nahee. tyanantarchya varshi, manvi ootee vaparnare pahile, durdamya apasmarachya shastrakriyedarmyan kadhoon takalelya manvi neocortical peshinvar kelelya abhyasat asey aadhalun aale qee ethosuximidecha upcharatmak prabhavasathi samanyatah aavashyak asalelya sandratevar see. aii. 2 + pravahanvar konatahi parinam jhaala nahee.
1998 madhye, slobodana emm. todorovic aanee christopher jeey. washington vidyapithachya lingalane prushthiy mool gangliamadhye tii-prakarchya pravahacha 100% block 23.7 ± 0.5 mimeol/ell nondavala, joou kostyukchya ahavalapeksha khoopach jaast aahe. tyach varshi, lereshe aanee itar. nondavale gele qee ethosuximidecha tii-prakarchya pravahanvar konatahi parinam jhaala nahee, parantu under aanee manjar thalamocortical peshinmadhye nishkriy naan honara naa + pravah 60 takkyanni aanee see. aii. 2 +-sakriy keey + pravah 39.1 ±. assa nishkarsh kadhanyat aala qee naa + pravahatil ghat hii anupasthit virodhi gunadharmansathi jababdar aahe.
2001 madhye prakashit jhalelya eka lekhachya parichayat dow. charlotsville yetheel virginia vidyapithatil juan carlos gomora aanee tyanchya sahakanyanni nidarshanas aanoon dile qee mageel abhyas bahutek vela vegalya neuronsmadhye kele gele hote jyanni tyanche bahutek tii-prakarche marg gamavale hote. clone kelele α1g, α1h aanee α1i tii-prakarchya calcium vahinyancha vapar karoon, gomorachya chamoola aadhalale qee ethosuximide 12 ±2 mimeol/elchya ic 50 aanee "aine"-desmithylmethsuxide (mesuximide sakriy chayapachay) heey α1g sathee 1.95 ± 0.19 mimeol/ell, α1i sathee 1.82 ± 0.16 mimeol/ell aanee α1h sathee 3 ± 0.3 mimeol/elsah vahinya avarodhit kelya aahet. jevha pravah aatalya dishene vahato tevha ethosuximidechya vahinyanna pratyakshapane jodalyamule khulya vahinyanche nakabandi sulabh hote asey suchavanyat aale hote.
stereochemistry.
ethosuximide heey stereocenter asalele kieral aushadh aahe. upcharatmakdrushtya, resmet, ("s") aanee ("r")-isomersche 1:1 mishran vaparale jaate.
samaj aanee sanskruti.
kharch.
2019 paryant americet utpadkankadun ethosuximidechya kimmati vadhavalya gelya asalyabaddal chinta hotee.
upalabdhata.
anek deshanmadhye ethosuximidechi upalabdhata maryadit aahe. emeside aanee zarontin yaa vyapari navanni tyache vipanan kele jaat hote. tathapi, donhi capsule tayari utpadanatun bund karnyat aalee, keval samanya tayari upalabdh rahili. 2005 madhye tyanchya utpadak, upayojit jivashastra prayogshalanni emeside capsule bund kele. tyachpramane, 2007 madhye pefizerne zarontin capsule bund kele. donhi brandchi sirap tayari upalabdh rahili.