
epherocytosis

peshi jivashastrat, epherocytosis ('epherre' pasoon, 'kabarimadhye nene', 'daphan karane' yasathi lattin) hii eka prakriya aahe jyadvare phagocytic peshindware apoptotic peshi kadhoon takalya jaatat. yala 'mrut peshinche daphan' manale jaau shakate.
epherocytosischya darmyan, phagocytic peshinche peshi puttle apoptotic peshila vyapate, jyamule mrut peshi asalela dravane bharalela eka motha putika tayar hoto. yaa aatalya putikachya gathila (phagosome yaa shabdachya sadrushyat) epherosome mhanatat. hii prakriya macropinocytosissarkhi aahe.
apoptosisasathi, epherocytosischa parinam assa aahe qee mrut peshi tyanchya padadyachya akhandatecha bhang honyapurvi kadhoon takalya jaatat aanee tyanche ghatak aajubajuchya uutinmadhye galatat. heey vishari enzymes, auxidants aanee proteages aanee caspaces sarkhya itar antakoshiy ghatakanchya samparkat yenyapasoon uutinna pratibandhit karate.
epherocytosis keval macrophages kinwa dendritic peshinsarkhya 'vyavsayik' phagocytic peshindvarech navhe tarr epithelial peshi aanee fibroblasts itar anek prakarchya peshindware dekhil keela jaau shakato. tyanna jiwant peshinpasoon vegale karnyasathi, apoptotic peshi vishisht 'eat mea' sanket vahoon netat, jase qee phosphatidil sereenchi upasthiti (phospholipid flip-flopmule) kinwa peshi patalatil bahya patrakavar caleticuline.
epherocytosis vishisht khalchya dishene antakoshiy sanket pareshan marganna chalana dete, udaharanarth parinami dahak-virodhi, protease-virodhi aanee vaadh vadhavnare parinam hotat. yaulat, bighadalele epherocytosis svayampratikar rog aanee uutinchya hanishi jodalele aahe. hepatocyte aanee raktavahinyanchya endothelial vadhicha ghatak yasarkhya madhyasthanchya sevan peshidvare epherocytosische utpadan hote, jeey mrut peshinchya badalyala protsahan detat asey manale jaate.
cystic fibrosis aanee bronchiactases, dirghakalin avarodhak fuffusiy rog, damaa aanee idiopathic fuffusiy fibrosis, sandhivat, pranaligat lupus erythematosus, glomerulonephritis aanee atherosclerosis yasarkhya roganmadhye sadosh epherocytosis disun aala aahe.
vishisht nirakaran samarthak madhyasth heey vishisht bahuasantrupt medyukt aamlanche peshi-vyutpann chayapachay asatat.: arakidonic aaml jeey lipoxinemadhye chayapachay hote; ecosapentenoic aaml jeey resolvin eae madhye chayapachay hote; docosahexenoic aaml jeey resolvin dii, maracine aanee neuroprotectinmadhye chayapachay hote; aanee aine-3 docosapentenoic aaml jeey aine-3 docosapentenoic aaml-vyutpann resolvins aanee aine-3 docosapentenoic aaml-vyutpann neuroprotectinmadhye chayapachay hote (vishesh nirakaran samarthak madhyasth pahaa). yaa madhyasthanmadhye aachchhadit kriyakalapanchi vistrut shreni asate jee jaljal door karnyasathi karya karate; yapaiki anek madhyasthankade asalelya mahattvachya kriyakalapanpaiki eka mhanje soojalelya uutinmadhye epherocytosischi uttejana. yaa madhyasthanchi pureshi matra tayar karnyat ayashasvi hone heey dirghakalin aanee rogshastriy dahak pratikriyanche eka kaaran prastavit aahe (vishesh nirakaranatmak mediators#spm aanee jaljal pahaa).