1-(3-chlorophenyl)-4-(2-phenylethyl) piperazine

1-(3-chlorophenyl)-4-(2-phenylethyl) piperazine piperazine heey rasayanik padarthanchya piperazine vargache eka designer aushadh aahe. kayadyantargat haah 'meta'-cholorophenylpyperasine (mcpp) aanee phenethylamineshy sambandhit aahe, jyacha mcpp mhanoon vichar keela jaau shakato, jyacha phenylethyl gut nitrogen anoola tyachya 4-sthanavar jodalela asato. sigma receptor legands mhanoon piperazine sanyuganchya malikecha khulasa khulasa petantmadhye 1994 madhye yache pahilyanda varnan karnyat aale hote. nantar, haah eka atyant shaktishali dopamine reaptech avarodhak asalyache aadhalun aale.
aushadhashastra.
kayadyantargat haah aataparyant nondavalelya sarvat shaktishali dopamine vahtook (dii. aii. tii.) legandpacky eka aahe. jawalcha sambandh asalelya norpenephrine transporter (nivval, keey = 1107 nm) aanee serotonin transporter (seart, keey = 802 nm) sathee tulanene qamee aatmiyata asalelya dopamine transportersathi (pruthakkaran sthirank keey = 0.14 nm) heey atyant nivadak aahe. yavyatirikt, sanyugamadhye sanyugamadhye receptor (keey = 327 nm), serotonin serotonin receptor (keey = 53 nm), opioid receptor (keey> 10000 nm) aanee pcp/nmda receptor (keey> 10000 nm) sathee qamee (kinwa nahee) aatmiyata aahe.
0. 04 nmchya dett pruthakkaran sthirank keey saha, 3 see-peepi haah sahityat aajparyant varnan kelelya sarvat shaktishali dopamine vahak legandpacky eka aahe. tyaa tulanet, koken jeey eka prototypical dett legand aanee reaptech inhibitor aahe, tyat 435 nmcha pruthakkaran sthirank k asato, jyamule kayadyantargat dopamine transporter inhibitor "inn vitro" mhanoon kokenpeksha sumare 10,000 putt adhik shaktishali banate.
kayadeshir sthitee.
united states.
kayadyantargat heey united statesmadhil federal staravar niyojit nahee.
canada.
niyantrit aushadhe aanee padarth kayadyantargat kayadyantargat nirdharit kelele nahee.

