
chromodoman helicase dii. aine. aii.-binding (see. etch. dii.) upkutumb

chromodoman helicase dii. aine. aii.-binding (see. etch. dii.) prathine hii aii. tii. pii.-aashrit chromatin punarnirmiti sankulanchi (punarnirmiti karnare) upkutumb aahe. serve punarnirmiti karnare aar. aine. aii./dii. aine. aii. helicase super family 2 chya chhatrakhali yetat. yeastmadhye, see. etch. dii. sankul pramukhyane nucleosome assembly aanee sanghatanesathi jababdar asatat. hii sankule bahukoshikiy eukeriotsmadhye atirikt bhoomika bajavtat, jyamule chromatin pravesh aanee nucleosome sampadan karnyat madat hote.
see. dii. upkutumb prathinanchi karye.
aii. tii. pii.-aashrit chromatin punarnirmitikartyanch anukaran switch (isvi) upkutumbapramanech, see. etch. dii. sankul dii. aine. aii. chya bajoone paripakv nucleosomechi rachana aanee sanghatan niyantrit karatat. dii. aine. aii. pratikrutichya darmyan histones kadhoon takale jaatat; pratikrutichya mage, histones navjat dii. aine. aii. varr aparipakv purv-nucleosome mhanoon ekatra yeu lagatat. see. etch. dii. sankulanchya madatine, histone octamer heey mool nucleosome paripakv houu shakatat. nucleosome tayar jhalyanantar, see. etch. dii. sankule nucleosomela dii. aine. aii. chya bajoone niyamitpane vegale karoon tyanchi vyavastha karatat.
yavyatirikt, uchch-kramatil jivanmadhil see. etch. dii. heey dii. aine. aii. praveshakshamta allosterically niyantrit karnyasathi nucleosomes kinwa histone diamer slide/baher kadhu shakatat. vishisht chd sankul, jase qee 'c' madheel nucleosome remodelling dactlase (nurd) sankul. elegans, "chromatinechya bajoone transcriptional repressorsathi bandhani sites atyant-modular histone shepatishi sanvad sadhun ughad karoo shakatat; histone avashesh etch3keey9aiiseeche desetilation heey nurd complexes januk abhivyaktiche niyaman kase qamee karoo shakate aanee dna topologiever kassa parinam karoo shakate yache eka udaharan aahe.
aii. tii. pii.-aashrit punarnirmitikartyanch yaa upkutumbatil antim yantrana mhanje nucleosome sampadan.  "drosophila" dii. see. dii. 1. heey etch. 3.3. yaa prakarasathi histone etch. 3. badaloon nucleosome sampadit karoo shakate. nucleosomajaval dii. see. dii. 1. chya bandhanyamule dii. aine. aii. madhye tanav nirman hoto. haah tanav door karnyasathi, varchya bajula asalela etch3 diamer nucleosomemadhun visthapit hoto, jyamule tyachi jaaga histone prakar etch3.3 neey gheta yete. nucleosome etch3.3 jodane haah chromatinla sulabh, pratilekhan-sajj sthiteet thevanyacha eka epigenetic marg aahe. paryayi histonescha samavesh aanee anuvadanantarche badal (pii. tii. emm. ess.) peshinchya histone kodache niyaman karnyat avibhajya bhoomika bajavtat.
see. etch. dii. upkutumb prathinanchi rachana.
see. dii. etch. upkutumbatil adviteey aine-terminal domenmadhye done chromodoman aahet. done lobe domain translocase domain (tii. aar.) mhanoon ekatra kaam karatat aanee peptide linkardware (anjir) jodalele asatat. 1). dii. aine. aii.-binding domain (dii. bii. dii.) yogyaritya bandhale jaiparyant negg * (iswimadhil negksarkhech) lobe halchal aanee sthanantaranachya pratibandhakache kaam karate. neeg * heey lobvar aii. tii. pii. hydrolysis rokhoon karya karate. dii. bii. dii. heey nucleotide shasak mhanoon dekhil karya karate, jeey ekmekanpasun nucleosomes samaan antar thevate. dii. aine. aii. bandhananantar, dii. bii. dii. mule dii. aine. aii. strandver taana yeto, parinami sanrachanatmak badal hoto jyamule niyamit nakaratmak * pratibandh rokhala jaato. yamule tii. aar. kshetra sakriy hote, parinami dii. aine. aii. sthanantar hote.
aii. tii. pii.-aadharit chromatin punarnirmiti sankulanmadhil dii. aine. aii.-sthanantaranachi samayik yantrana.
dii. aine. aii. sthanantaranachi tii. aar. yantrana serve aii. tii. pii.-aadharit chromatin punnirmatyandvare sanrakshit kelee jaate; dii. aine. aii. sthanantarasathi done rikasarkhe khand yantrikdrushtya jababdar asatat. nucleosomepasoon done helical valane door kelyanantar, complexamule varr namood kelelya nucleosomechya varchya bajula eka-done bases jodya halatat. yaa aii. tii. pii.-chalit yantranet, jalvichhedanatun milananya urjemule, nucleosome yogyaritya ekatra kele jaiparyant, pravesh keela jaiparyant kinwa sampadit keela jaiparyant, dii. aine. aii. chya bajoone nucleosome diedchya dishene lobe 'croll' karatat.
hehee pahaa.
kutumbatil prathineh