tynelic aaml

tianilic aaml (inn aanee bann) kinwa tikrinaphen (yu. ess. aii. aine.) heey euric aaml-qamee (euricosuric) krutee asalele loop mutravardhak aushadh aahe, jeey purvi uchch raktadabavaril upcharansathi vikale jaat asey. 2 meey 1979 roji eff. dii. aii. neey yala manyata dilee aanee 1982 madhye united statesmadhil prakarananchya ahavalanni tikrainaphen aanee hipatitieschya vaparatil sambandh darshavlyanantar too mage ghetala.
eff. dii. aii. chee manjuri midavatana vishaktateshi sambandhit mahitee lapavanyachya sandarbhat smithcline smithcline faujdari aarop karnyat aale. companyne pratikool pratikriyancha ahwal denyat ayashasvi tharalyachya 14 gunhyansathi aanee chukichya branded aushadhachya vikrichya 20 gunhyansathi doshi tharavale.
aushadh chayapchayamadhye guntalelya cytochrome pii 450 enzymesver teanelic acid aatmahatya thurr mhanoon karya karat asalyache aadhalun aale. tathapi, yaa enzymesdware kelelya chayapachay pratikriyene teanelic acidche thiophene sulfoxidemadhye rupantar kele jeey atyant electrophilic hote. yamule maykal abhikriyes protsahan midale jyamule enzymechya sakriy thikani thayol gatache alkylation jhaale. thiophene sulfoxidemadhun paanee galoon padalyane thiophene ring punarsthapit jhaali aanee parinami tynelic acid heey enzymeshy sahasanyojakpane jodale gele, jyamule enzyme aparivartaniyapane pratibandhit hote.
yavyatirikt, heey aushadh ghetalyanantar yakrut nikami jhalelya rugnanchya seramadhye nantar sayyap2see9 pratipinde hotee, jee aushadh hydroxylate karnyas aanee sahsanyojak bandhan denyas saksham hotee.
vareel spashtikaran heey eka gruhitak aahe. nantar nishkriy karnara pratikriyashil madhyavarti mhanje thiophene sulfoxide kinwa thiophene epoxide aahe qee nahee heey adyap (15 varshannantar) dnyat nahee. prathinanvaril lakshya dekhil dnyat nahee (ekadhik asoo shakate). tathapi, teanelic aaml heey nantar chey eka changle yantrana aadharit avarodhak aahe aanee teey stoikiometrikdrushtya nishkriy karate asey disate. proteomixmadhil pragati eka divas uttar deu shakate.
alikadil abhyas asey soochit karatat qee pratyakshat teanelic acidche (5-oh teanelic acid) prathamik chayapachay heey purvi gruheet dharale gelyasarkhe theophene-ess-auxide madhyavarti pasoon midavata yet nahee. heey thiophene epoxide madhyavarti pasoon vyutpann asalyache nishchit kele gele aanee haah pratikriyashil madhyavarti nantar nantar chya sahsanyojak bandhanache tasech yantrana-aadharit nishkriyateche kaaran asanyachi shakyata aahe.

