
sayyap2aar1

sayyap2aar1 heey cytochrome pii450 2aar1 heey eka enzyme aahe, jeey dii 25-hydroxylase jivansatvatil pramukh ghatak aahe. manavanmadhye teey gunasutra 11p15.2 varr asalelya "sayyap2aar1" janukadware encode kele jaate. teey yakrutatil endoplasmic reticulummadhye vyakt kele jaate, jithe teey 25-hydroxyvatamine deechya nirmitila utprerit karoon jivansatva dii sakriy karnyachya pahilya payarichi kamgiri karate.
jivansatva dii 25-hydroxylase kriyakalapamadhye itar kahee cytochrome pii 450 enzymes dekhil asatat, visheshtah sayyap27aii1, jeey mitochondriamadhye aadhalate.
karya.
sayyap2aar1 haah cytochrome pii450 yaa enzymeschya super familicha sadasya aahe. cytochrome pii 450 prathine hii mono-oxygenjanya asatat jee aushadh chayapachay aanee collesterol, steroids aanee itar lipidschya sanshleshanat samavisht asalelya anek pratikriyanna utprerit karatat.
sayyap2aar1 heey yakrutachya endoplasmic reticulummadhye (sukshmasangitak ansh) asate. yaat 25-hydroxylase kriyakalap aahe, jeey collecalciferolche (jivansatva dii3) calcifidiolmadhye (25-hydroxyvitamine dii3, jyala calcidiol asehi mhanatat) rupantar karate, jeey jivansatvache pramukh parisancharan swaroop aahe. sayyap2aar1 heey aahar strotanmadhun milanare ergocalciferol (jivansatva dii2) dekhil hydroxylate karoon 25-hydroxyvitamine dii2 (ercalcideol) madhye rupantarit karel. jivansatva dache heey 25-hydroxylated prakar, jyanna ektritpane 25 (oh) dii mhanoon olakhale jaate, teey raktatil jivansatva dii-bandhan prathinanshi drudhpane bandhale jaatat aanee jivansatva deeche pramukh parisanchari prakar aahet. samanyatah ekhadya vyaktichi jivansatva daad chee sthitee nishchit karnyasathi aanee jivansatva daad chee kamatarata sthapit karnyasathi heey mojale jaatat.
calcifidiol nantar 25-hydroxyvitamine dii3 1-alfa-hydroxylase krutidvare calcitriolmadhye rupantarit hote, jeey jivansatva dii3 chey sakriy roop aahe jeey jivansatva dii receptorshee (vhee. dii. aar.) bandhale jaate aanee jivansatva deechya bahutek sharirik samprerak kriyanmadhye madhyasthi karate.
vaidyakeey mahatva.
jivansatva daad, visheshtah collecalciferolche 25 (oh) dii (calcifediol) madhye rupantar karane hii jivansatva dii samprerak pranalitil eka pramukh payari aahe. hii prakriya sadhya karnari sayyap2aar1 utsechak kriya purvi rachnatmakpane vyakt aanee sthir asalyache manale jaat hote, jenekarun seeram 25 (oh) dii heey jivansatva deechya purvathyache eka mojmap hote.
sayyap2aar1 aata niyantrit mhanoon olakhale jaate, sayyap2aar1 chya abhivyaktitil badal aanee kriyakalap 25 (oh) dii chya parisancharanavar parinam karatat. 24 taas upvas kelyanantar, laththapana, prakar 1 aanee prakar 2 madhumehat sayyap 2 aar 1 kriyakalapanchi qamee patali aadhalali aahe aanee dexamethasonsarkhya glucocarticoidsmule qamee hote. yaa paristhiticha sambandh 25 (oh) deechya qamee rakt patalishi asalyache dnyat aahe, jithe jivansatva deechya mothya matranmulehi sudharana houu shakat nahee, jeey enzyme kriyakalap qamee asalyamule spasht kele jaau shakate.
sayyap2aar1" madheel bahuroopi bhinnata.
itar janukanchya bhinnatechya tulanet "sayyap2aar1" janukatil bahuroopi badalancha vaiyaktik seeram 25 (oh) dii sandratevar sarvat jaast parinam hoto. sayyap2aar1" januk ell99pii madheel varshane midalele utparivartan, jyamule coden 99 yethe lucine avasheshasathi prolinchi jaaga ghetali jaate, enzymechi kriya door hote aanee teey jivansatva dii-aadharit rickets prakar ibshi sambandhit asate. dusra prakar mhanje keey242aine, jithe 242 vya sthanavaril licinela esparagine badalale jaate, tyach prakarcha phenotype dete. 25 (oh) dii chee qamee parisancharan patali aanee jivansatva deechya kamataratechi abhijat lakshane hii lakshane aahet.
undarancha abhyas.
sayyap2aar1 karyachya abhyasat pratikruti jivancha vapar keela gela aahe. sayyap2aar1' aanee 'sayyap2aar1' aanee 'sayyap27aii1' yaa donhichya baad feridware under tayar kele gele aahet. sayyap2aar1tm1bii (yucom) wtci" navachi sashart baad ferichi maus line tayar karnyat aalee aahe aanee pranyanchya pramanit phenotypic screenmadhun gele aahe.