
proteolypid

proteolypid heey lipid renunshi sahasanyojakpane jodalele prathine aahet, jeey fatty acid, isoprenoids kinwa sterols asoo shakatat. asha jodanichya prakriyela prathine lipidation mhanatat aanee tee assilation aanee anuvadanantarchya badalachya vyapak shreneet yete. proteolypids menduchya uutinmadhye mubalak pramanat asatat aanee itar anek prani aanee vanaspatinchya uutinmadhyehi asatat. tyamadhye aaharabarobar sambandhit peptide samprerak ghrelinacha samavesh hoto. anek proteolypids heey charbiyukt aaml sakhalyanshi sahasanyojakpane bandhalelya prathinanni banalele asatat, jyamule tyanna anekada jaivik patalanshi sanvad sadhanyasathi interfaces midato. tyancha lipoproteins gondhal houu naye, lipidschya anek renunpasoon aanee kahee apolypoproteinspasoon banalelya golakar assemblicha eka prakar.
rachana.
prathinanshi jodalelya medyukt aamlachya prakaranusar, proteolipidmadhye anekada myristoil, palmitoyal kinwa preneal gut asoo shakatat. heey gut pratyek vegvegalya karye karatat aanee teey konatya amino acid avasheshanshi jodatat yabaddal tyanchi vegvegali pradhanye aahet. yaa prakriyanna anukrame myristoilation (samanyatah aine-terminal gliver), palmitoilation (systeinmadhye) aanee prenelation (systeinmadhye dekhil) asey naav dile jaate. varvar pahata vishisht nave asoonahi, aine-myristoilation aanee ess-palmitoyleshanmadhye itar kahee medyukt aaml dekhil samavisht asoo shakatat, jeey samanyatah vanaspati aanee vishanujanya proteolipidsmadhye aadhaltat. lipid-anker prathinanvaril lekhat yaa canonical vargambaddal adhik mahitee aahe.
lipidated peptides haah peptide amphifilecha eka prakar aahe jyamadhye peptidechya mukhya gatala jodalelya eka kinwa adhik alkyle/lipid sakhalya asatat. peptide anfifilespramanech, teey hydrophilic/hydrophobic santulan tasech peptide ekkanmadhil parasparsanvadavar avalambun swayam-ekatra hotat, jeey amino acid avasheshanchya charjvar avalambun asate. lipidated peptides heey amphiphilic surfactantschee sanrachanatmak vaishishtye bioactive peptideschya karyansah ekatra karatat aanee teey vividh nanostructuremadhye ekatra yenyasathi olakhale jaatat.
karya aanee anuprayog.
peptideschya uchch receptor aatmiyata aanee jaivkriyashilata aanee qamee visharipana yasarkhya vanchhaniy gunadharmanmule, upcharanmadhye peptidescha vapar (i. eae. peptide upcharpaddhati mhanoon) mothee kshamata aahe; 100 hoon adhik manjur peptide-aadharit aushadhansah vegane vadhana bajarpethet heey disun yete. peptideschi maukhik jaivupalabdhata aanee sthirata qamee asate heey tyache tote aahet. upcharatmak ghatakanchya vikasatil rasayanik badal sadhan mhanoon lipidation heey yaa samasyanvar maat karnyasathi upayukt asalyache siddha jhaale aahe, sadhya manavanmadhye vaparnyasathi manjur kelelya chaar lipidyukt peptide aushadhansah aanee itar anek vaidyakeey chachanyanmadhye. manyataprapt aushadhanpaiki done aushadhe mhanje dirghkal kaam karnari madhumehavirodhi jee. ell. pii.-1 analogue lyraglutide (victosa) aanee insulin detemir (levemier). itar done pratijaivike mhanje daptomycin aanee polymixin bii.
saundaryaprasadhan udhyogat vaparasarkhya itar kshetranmadhye dekhil lipidated peptidesche upayog aahet. vyavsayikdrushtya upalabdh asalele lipidated peptide, matrixil, surkutya-virodhi kreemmadhye vaparale jaate. matrixil heey eka pentapeptide aahe aanee tyat sanlagn pamitoyal lipid sakhalisah anukram kttks aahe, jeey fibroblastmadhye collegen aanee fibronectin utpadan uttejit karnyas saksham aahe. anek abhyasanni pamitoyal-keey. tii. tii. keey. chey aashadayak parinam darshavile aahet aanee sthanik formulationmule bareek resha aanee surkutya lakshaniyaritya qamee hotat, jyamule tvachetil vruddhatva prakriyela vilamb honyas madat hote. hamley gatane pamitoyal-keey. tii. tii. keey. chee tapasani dekhil kelee aahe aanee manvi tvacharog aanee parpatalachya tantumay granthila ekagratevar avalambun asalelya paddhatine uttejit karnyavyatirikt, ph shreni 3-7 madhye nanoe tepmadhye teey swatahun ekatra asalyache aadhalale aahe, jeey soochit karate qee uttejana gambhir ektrikaran ekagratechya varr hote.
prathinanchya assilation kahee durmil prakar astitvat aahet jyanche puttle-sambandhit karya nasel. tyamadhye ghrelinmadhil serine oo-octanoilation, doubleu. aine. tii. prathinanmadhil serine oo-palmitoleyaleshan aanee ell. pii. see. tii. 1 saha histone etch. 4 madheel oo-palmitoilation yancha samavesh hoto. hejahog prathine (aine-) palmittet aanee collesteroldware duheri-sudharit kelee jaatat. tvacheche kahee seramides heey proteolypids asatat. qamee samajalya gelelya yantranedvare licinveril amino gut myristoilation dekhil asoo shakato.
jivanunmadhye.
serve jivanu tyanchya peshi patalat proteolypids vapartat, jyanna kadhikadhi gondhalat takanare jivanuyukt lipoproteins mhanoon sambodhale jaate. eka samanya badalamadhye aine-terminal cysteine avasheshala jodalele aine-esil-aanee ess-diacylglycerol asatat. gramm-negative jivanunmadhye aadhalanare bronche lipoprotein heey yaa gatache pratinidhi aahe. yavyatirikt, mycobacterium oo-micolate prathine bahya patalasathi niyat aahet. vanaspati chloroplast heey proteolipidsmadhye jivanu karatat tyach prakarche anek badal karnyas saksham aahe. asha aine-esil diacyl glycerillated seela wall proteolipidsasathi eka databases mhanje dolop.
rogkarak spirocates, jyat "buub" samavisht aahe. bergdorferry aanee tii. pallidum, "pidit peshinna chikatoon rahnyasathi tyanche proteolypid adhessins vapara. hii prathine dekhil shaktishali pratijan aahet aanee pratyakshat yaa done prajatinche mukhya rogpratikarak aahet.
proteolipidsmadhye jivanu pratijaivikancha samavesh asato jeey raybosommadhye sanshleshit kele jaat naheet. nonrebosomal peptide syntheschya utpadananmadhye lipidshee jodaleli peptide rachana dekhil asoo shakate. hyanna sahasa "lipopeptides" asey mhanatat. jivanuyukt "lipoproteins" aanee "lipopeptides" (ell. pii.) heey sepsisache shaktishali prerak aahet, jeey jaljal pratisad denyachya kshamatet lipopolysaccharide (ell. pii. ess.) nantar dusya kramankavar aahet. ell. pii. ess. toll-sarkhya receptor tii. ell. aar. 4 dware shodhala jaato, tarr ell. pii. ess. tii. ell. aar. 2 dware shodhala jaato.
"basilus".
anek proteolypids basilus subtillis kutumbadware tayar kele jaatat aanee teey 7-10 amino acidney banalelya chakriy sanrachanene aanee 13-19 carbon anoonpasun vegvegalya lambichya beeta-hydroxy fatty acid sakhaline banalele asatat. chakriy peptide anukramachya sanrachanenusar hyanche teen kutumbanmadhye vibhajan kele jaau shakateh cerfactin, iturin aanee fengicin. basilus prabhedanni tayar kelelya lipidated peptidesmadhye jivanuvirodhi, vishanuvirodhi, burshivirodhi aanee tumourvirodhi gunadharm yasarkhya anek upayukt jaiv-kriya asatat, jyamule teey vividh udhyoganmadhye vaparnyasathi atishay aakarshak banatat.
cerfactin.
navapramanech, cerfactin heey shaktishali biosurfactants (jivanu, yeast kinwa burshindware tayar honare surfactants) aahet aanee teey atishay qamee sandratesah panyacha prushthbhagavaril taana 72 teey 27 dashalaksh/meetarparyant qamee karatat asey disun aale aahe. yavyatirikt, cerfactin lipid membrainla pargamya karnyas dekhil saksham asatat, jyamule tyanna vishisht pratijaivik aanee vishanuvirodhi kriyakalap karata yetat. cerfactin heey biosurfactants asalyane, tyanche vividh karyatmak gunadharm aahet. yamadhye qamee vishaktata, jaivavighatanakshamta aanee tapman aanee piechchya badalanprati uchch sahishnuta yancha samavesh aahe, jyamule teey vividh prakarchya anuprayoganmadhye vaparnyasathi atishay manoranjak banatat.
iturin.
iturin heey burshivirodhi kriyakalapansah chhidra tayar karnare lipopeptides aahet aanee heey lakshyit peshinchya cytoplasmic padadyashi honanya parasparsanvadavar avalambun asate. mycosubtillin heey eka iturin isophorm aahe jeey tyachya sterol alcohole gatadware padadyanshi sanvad sadhu shakate, ergosterola (burashimadhye aadhalanare sanyug) lakshya karnyasathi tyala burshivirodhi gunadharm dete.
fengisin.
tantumay burashiviruddha burshivirodhi kriyakalapansah, fangicins haah basilus subtilisdware utpadit biosurfactantcha aanakhi eka varg aahe. fengisin aii aanee fengisin bii heey done varg aahet, jyamadhye peptide kramvarit 6 vya sthanavar asalelya eka amino esiddware done bhinn aahet, jyat pahilya bhagat allenine avashesh aahet aanee dusyamdhye valine aahe.
"streptomysis".
daptomycin heey aanakhi eka naisargikaritya aadhalanare lipidated peptide aahe, jeey gramm positive bacterium "streptomyces rosoporus" dware tayar hote. daptomycin sanrachanet anshatah chakriy peptide mukhya gatala jodaleli decanoil lipid sakhali asate. yaat atishay shaktishali pratijaivik gunadharm aahet aanee emm. aar. ess. aii. (methicillin-pratirodhak staphylococcus aurius) aanee vancomycin pratirodhak enterococci yasah gramm positive jivanunmule honanya jivghenya paristhitivar upchar karnyasathi pratijaivik mhanoon vaparale jaate. basilus subtillis lipidated peptidespramanech, peshi patalamadhye pravesh kelyane tyache gunadharm midatat aanee daptomycin krutichya yantranet vighatan ghadavun aananyasathi jivanu patalat decanoil sakhali samavisht karane samavisht aahe asey manale jaate. yamule nantar gambhir vidhruvikaran hote, parinami dii. aine. aii., prathine aanee aar. aine. aii. yasah vividh sanshleshan prakriya pratibandhit hotat, jyamule apoptosis hoto.