
panobinostat

fariduck yaa brand navane vikale jaanare panobinostat heey eka aushadh aahe jeey multiple myelomachya upcharasathi vaparale jaate. heey eka hydroxamic aaml aahe aanee nivad naan kelele histone dactlase avarodhak (panne-etch. dii. aii. see. avarodhak) mhanoon karya karate.
februwari 2015 madhye americet aanee august 2015 madhye european unionmadhye vaidyakeey vaparasathi panobinostatla manyata denyat aalee. tathapi, march 2022 madhye, americet tee mage ghenyat aalee.
vaidyakeey vapar.
panobinostatcha vapar karkarogvirodhi aushadh bortezomib aanee corticoid dexamethasonechya sanyogane, jyanna bortezomib aanee immunomodulatory agents kiman done purviche upchar midale aahet asha praudhanmadhye multiple myelomachya upcharansathi keela jaato.
matbhed.
stanpan karananya matanmadhye panobinostatche matbhed aahet. pranyanvaril prayoganvarun nirnay ghenyasathi, garbhadharanedarmyan vaparlyas naan janmalelya balasathi dhoka aahe; tarihi, panobinostatcha fayda yaa jokhamipeksha jaast asoo shakato.
dushparinam.
samanya dushparinamadhye (10 takkyanhun adhik rugnanmadhye) qamee raktapeshinchi sankhya (pansitopenia, thrombocytopenia, raktakshay, leukopania, neutropania, lymphopania), vayumargatil sansarg, tasech thakwa, atisar, malmal, dokedukhi aanee zopechya samasya yasarkhya anirdisht pratikriyancha samavesh hoto.
aushadhashastra.
krutichi yantrana.
panobinostat anek histone dactlase enzymesna pratibandhit karate, jee eka yantrana aahe jyamule anek margandware ghatak peshinche apoptosis hote.
pharmacokinetics.
panobinostat aatadyatun patkan aanee jawaljawal purnapane shoshala jaato, parantu tyacha lakshaniy first-paas prabhav asato, parinami ekoon 21 takke jaivupalabdhata hote. pragat karkarog asalelya rugnanmadhye raktatil plasmachi sarvoch patali done tasannantar gathali jaate. plazma prathinanche bandhan sumare 90 takke asate. yaa padarthache chayapachay pramukhyane yakrutatil sayyap3aii4 yaa enzymedware oxidationdware aanee thodya pramanat sayyap2dii6 aanee sayyap2see19 dware kele jaate. too anirdisht enzymesdware qamee, hydrolysed aanee glucoronidise dekhil keela jaato. serve chayapachay nishkriy asalyache disate.
jaivik ardhayushya 37 taas asalyacha andaj aahe. 29-51% mutradvare aanee 44-77% maladware utsarjit kele jaatat.
clinical chachanya.
tisya tappyatil chikitsalayin chachanyanmadhye hodgkins lymphoma, tvachechya tii seela lymphoma (see. tii. see. ell.) aanee itar prakarchya ghatak roganviruddha, dusya tappyatil chachanyanmadhye myelodysplastic syndrome, stanacha karkarog aanee prostate karkarog yanviruddha aanee pahilya tappyatil chachanit dirghakalin myelomonocytic leukemia (see. emm. emm. ell.) viruddha tyachi chachani kelee jaat aahe.
 panobinostatcha vapar pahilya/dusya tappyatil vaidyakeey chachanit keela jaat aahe jyacha uddesh atyant sakriy antiretroviral therapy (haart) asalelya rugnanmadhye upchar karane haah aahe. yaa tantrat, etch. aay. vhee. dii. aine. aii. laa rugnachya dii. aine. aii. madhoon baher kadhanyasathi panobinostatcha vapar keela jaato, yaa apekshene qee rugnachi rogpratikarak shakti hartchya sanyogane tee nasht karel.
 panobinostatcha abhyas dusya tappyatil chachanimadhye, punha pasarlelya aanee apavartak pasarlelya mothya bii-seela lymphoma (dii. ell. bii. see. ell.) sathee keela jaat aahe.
purv chikitsalayin abhyas.
meyo klinikchya abhyasat prayogshalet swadupindachya karkarogachya peshi nasht karnyasathi panobinostat serolimus samanvayatmakapane karya karate asey aadhalun aale aahe. abhyasat, tapaskartyanna asey aadhalale qee yaa sanyojanane 65 takkyanparyant susanskrut swadupindachya arbud peshi nasht kelya. haah shodh mahattvapoorn aahe kaaran abhyas kelelya teen peshi resha serve chemotherapychya parinamas pratirodhak hotya-jase qee anek swadupindachya arbudansarkhe.
pathichya kanyachya snayu shoshanachya rugnanchya peshinmadhye motor neuron (ess. emm. aine.) prathinanchya pataliche astitva tikavoon thevanyasathi panobinostat "inn vitro" madhye lakshaniy vaadh karat asalyache dekhil aadhalun aale aahe.
jee2-emm. dii. aine. aii. nuksan tapasani kendravar hyperacetylation aanee peshi chakr atak karoon panobinostat nivadakpane tiheri nakaratmak stanachya karkarogachya (tii. aine. bii. see.) peshinna lakshya karnyat saksham hota; stanachya karkarogachya peshinchya vaishishtyapurn aakarshastriy badalanna anshatah ulatat hota.
itar etch. dii. aii. see. avarodhkansah panobinostatcha, supt sankramit peshinmadhye vishanu etch. aay. vhee.-1 abhivyakti prerit karnyachya aanee vilambata badhit karnyachya sambhavyatesathi dekhil abhyas keela jaat aahe. yaa vishranti peshinna rogpratikarak pranalidware vishanula aashray denari mhanoon olakhale jaat nahee aanee tyaa antiretroviral aushadhanna pratisad dett naheet.
2015 chya abhyasat asey suchavale gele aahe qee panobinostat haah vitro aanee vivomadhye pasarlelya aantarik pontin glioma peshinchi vaadh rokhanyasathi prabhavi hota, aanee tyala sambhavya aushadh umedvar mhanoon olakhala.