drushya abhimukhata prakriyet serotoninchi bhoomika

serotonin (5-hydroxytryptine) haah eka monoamine neurotransmitter aahe joou manahsthiti, khane, zopane, uttejana aanee sambhavya drushya abhimukhata prakriyet bhoomika bajavato. drushya abhimukhata madhye tyachya karyacha tapas karnyasathi, sanshodhakanni emm. dii. emm. aii. chaa vapar keela aahe, kinwa jyala samanyatah parmanand (3,4-methylnedioxymethamphate) asey sambodhale jaate. emm. dii. emm. aii. mendutil serotonin neuronsver parinam karnyasathi aanee neurotoxicityla karanibhoot tharnyasathi olakhale jaate. emm. dii. emm. aii. vaparnari vyakti jhukalelya parinamachya (tii. aii. eae.) parimanat vaadh darshavtat mhanoon serotonincha drushya abhimukhtashi sambandh asalyache gruheet dharale gele aahe. taee haah eka drushya bhram aahe jithe eka dishene dishene resha, dirgh kalavadhisathi, nantar pahilya gelelya ubhya reshanchya viruddha dishene jhukanyachi dharana nirman karatat. ausipital lobmadhil abhimukhata sanvedanshil neuronschya bajukadil pratibandhamule haah parinam udbhavanyacha prastav aahe. parshvik pratibandh mhanje jethe vishisht dishene sakriy mendumadhye neurons tyanchya shejarchya neuronsana avarodhak sanket pathavtat. pratyek neuron jyaa dishene jastit jaast uttejit hoto tyala tuning bandwidth mhanatat. parinami, pratyek neuronchya tuning bandwidthmadhye parshvik avarodh mahattvachi bhoomika bajavate, jase qee jarr parshvik pratibandh yapudhe hott nasel tarr adhik sankhyak neurons samaan dishene uttejit hotil. jarr uttejana kahee kalasathi pahili gelee tarr yacha parinam sakriy neurons tyach abhimukhata uttejananshi julavun ghetat. parinami, jarr tyaa neuronsana nantar aanakhi eka uttejana 'dakhavali' gelee jee tyachya dishene kinchit vegali aahe, tarr tyaa neuronsana itar gair-anukulit neuronschya tulanet samaan patalicha pratisad midavata yet nahee.
parinami, abhyasanni emm. dii. emm. aii. chya vaparamule mendumadhye parshvik pratibandhachya pramanache moolyankan karnyasathi taicha vapar keela aahe. yaa abhyasanchya nikalanna drushya abhimukhata madhye serotoninchya bhoomikeche samarthan karnare purave midale aahet. heey asha vyaktindvare siddha jhaale aahe jyanni keval emm. dii. emm. aii. chaa vapar karoon aushadhanchya nishkapat niyantrananchya tulanet techya mothya pramanacha ahwal deela. yaa vadhiv parimanane asey darshavile qee serotonin sambhavyapane sanman prabhav padoon parshvik pratibandhat bhoomika bajavate, yacha arth abhimukhata neurons tyanchya pasantichya abhimukhtababat jastit jaast utsahi hotat aanee itaransathi qamee. heey emm. dii. emm. aii. chya neurotoxicityche aanakhi purave dekhil pradan karate. sanshodhanachya yaa kshetrane, ekandarit, drushya abhimukhata prakriyechya yantranebaddal aanee yaa pranalivar emm. dii. emm. aii. neurotoxicitycha kaay parinam hoto yabaddal antardrushti pradan kelee aahe. yamule drushya pranalivar serotoninchi bhoomika aanee emm. dii. emm. aii. neurotoxicity menduvar kitee pramanat parinam karate yaa donhichi samaj vadhate.
emm. dii. emm. aii. chaa itihas aanee parinam.
extasy heey rastyache naav aahe jeey lokpriy manoranjak aushadhacha sandarbh dete jyamadhye 3,4-methylinedioxinemathamphate (emm. dii. emm. aii.) asate. rave aanee clubchya drushyat aata varanvar vaparale jaanare aushadh pratham merc yaa german pharmaceutical companyne sanshleshit kele hote, jee 1900 chya dashakachya suruvatila naveen aushadhanchya vikasachi chaukashi karat hotee. tyachya vikasapasoon, 1970 chya dashakat upcharatmak madat mhanoon vadgrastapane vaparnyapasun teey 1980 chya dashakat amali padarth amalbajavani prashasanane tyala vyasan asalyache nishkarsh kadhalyanantar bandee ghalanyaparyant, tyache vividh tappe gele aahet. tathapi, 1970 chya dashakat aanee tyanantar, anand, sahanubhooti, samajik jawalik, saumya matibhram aanee uttejan yaa bhavna nirman kelyamule emm. dii. emm. aii. heey eka lokpriy manoranjanatmak aushadh banale. yaa aushadhachya lokpriy vaparamule nantar samanya lokanmadhye chinta vadhali aahe kaaran prani aanee manvi abhyasanni asey darshavile aahe qee tyat mendula neurotoxicity nirman karanyachi kshamata aahe.
emm. dii. emm. aii. haah amphetamine kutumbacha eka bhag aahe aanee mendutil serotonin, dopamine aanee norpinephrine neurotransmitterchya patalit badal karoon tyache sakaratmak parinam darshavito. aushadh prabhavi honyas suruvat hote, tevha mendumadhye serotonincha puur yeto, jeey sevan kelyanantar 3 teey 6 tasanchya aat qamee houu shakate. heey dekhil disun aale aahe qee serotonin sanshleshit karnyasathi aavashyak asalele enzyme nishkriy hote, tyamule menduchya vaparlelya serotoninchya punarpurtila pratibandh hoto. emm. dii. emm. aii. chya sevanadarmyan aanee tyanantar mendumadhye mendumadhye badalanmule, vividh parinam lakshat aale aahet. yamadhye smaranshaktichi kamatarata, chinta, vyagrata, manahsthititil badal aanee nairashya yancha samavesh aahe. yamule emm. dii. emm. aii. menduchya rasayanshastrala kitee pramanat haanee pohochavu shakate aanee badaloo shakate aanee tyachya vaparkartyansathi yacha kaay arth hoto yabaddal aanakhi chinta nirman jhaali aahe.
emm. dii. emm. aii. aanee visual orientation processing.
emm. dii. emm. aii. chaa tapas tapas alikadil sanshodhanat menduchya serotonin neuronsver aushadhacha neurotoxic prabhav ughad jhaala aahe. prani aanee narvansh abhyasanmadhye serotonergic akshatantunmadhye dirghakalin aanee sambhavya kayamswarupi badal nondavale gele aahet, jethe tyanna kahee manvi vaparkartyanni ghetalelya emm. dii. emm. aii. chya matrepramanech denyat aale hote. tyanantar emm. dii. emm. aii. chaa vapar drushya abhimukhata prakriyet serotoninchi bhoomika kaay asoo shakate yacha tapas karnyasathi keela gela aahe. serotonin neurons heey ausipital lobmadhye rahatat asey manale jaate, jeey menduche eka kshetra aahe jeey reshechi abhimukhata, kadaa, gatee aanee stereoscopic kholichya aakalananchya drushya prakriyesathi jababdar aahe. emm. dii. emm. aii. haah serotoninavar parinam karnyasathi olakhala jaato aanee serotonin drushtimadhye samavisht asalyache manale jaate, emm. dii. emm. aii. aii vyakti tyanchya drushya abhimukhata prakriyet farak darshavu shakatat.
1990 chya dashakat maisini, antonietti aanee moja (1990) yanni kelelya purv abhyasanantar, drushya abhimukhata prakriyet emm. dii. emm. aii. chaa prabhav aanee serotoninchya bhoomiketil sambandh tapasanyat aala aahe. tyanchya prayogat eka mishran sevan karnare vishay samavisht hote jyamule mendutil serotoninchi patali lakshaniyaritya qamee jhaali. serotoninmadhil yaa ghatmule tyaa vishayanmadhye techya parimanat vaadh jhaali. yaa abhyasacha vapar tevhapasoon yaa kalpanecha paya mhanoon keela gela aahe qee emm. dii. emm. aii. neurotoxicity, serotonin neuronsveril prabhavamule, emm. dii. emm. aii. vaparnarya vyaktinmadhye techya parimanavar prabhav takoo shakate.
vartaman sanshodhan.
emm. dii. emm. aii. chya vaparatoon badalalelya drushya abhimukhata prakriyesandarbhat sadhyache nishkarsh pandhare, tapkiri aanee edward (2013) yanchya sanshodhanatun aale aahet. tyanchya abhyasane mycini aanee itaransarkhya mageel sanshodhanat aadhalalelya parinamancha vistar karnyacha prayatna keela. (1990), aanee emm. dii. emm. aii. ausipital lobmadhil drushya prakriyevar kassa parinam karato yacha tapas qaraa. abhyasatil sahbhaginna teen gatanmadhye vibhagale geleh amphetaminepasoon door rahilele parmanand vaparkarte, amphetaminecha vapar karnare parmanand vaparkarte aanee amali padarthanche nishkapat niyantran karnare sahbhagi. jyaa parmanand vaparkartyanni amphetaminecha atirikt vapar keela tyanna purvichya abhyasanchya parinamanchya rupat samavisht kele gele aahe asey soochit kele aahe qee samvarti amphetaminecha vapar abhimukhata neuronsver emm. dii. emm. aii. chya prabhavanmadhye madhyasthi karoo shakato.
abhyasachya nikalanni asey soochit kele qee amphetaminechya amoort parmanand gatane niyantrananpeksha vyapak tuning bandwidth darshavili. heey darshavate qee emm. dii. emm. aii. chya vaparamule serotonergic karyat badal hotat kaaran teey abhimukhata sanvedanshil neuronsemadhil bajukadil avarodhat vyatyay aanate. yaa vyatyayamule neurons tyanchya pasantichya abhimukhtashivay itar dishanchya vistrut shreneet sakriy hotat. tyamule, haah shodh, serotonin abhimukhata neuronschya tuning bandwidthla tikshna karnyat bhoomika bajavate yaa kalpanela samarthan deto. ekandarit, parinam yaa kalpanela samarthan detat qee "emm. dii. emm. aii.-madhyasth serotonin qamee jhalyamule vyapak abhimukhata tuning bandwidth houu shakatat". 163. tathapi, lekhak pudhe mhanatat qee kahee kamanmadhye kamatarata asali taree yaa kamataratechya vyaptichi adhik chaukashi aavashyak aahe.
braun, edward, macon aanee ward (2007) yanni kelelya abhyasat, serotonin neuronsver emm. dii. emm. aii. chya parinamachi dekhil tapasani kelee. tyanche sanshodhan dekhil masini aanee itarankadun jhaale. (1990). tyanna sanvedanshil neuronschya abhimukhatachya bajukadil pratibandhamadhye serotoninchya bhoomikemadhye aanee emm. dii. emm. aii. chaa vapar hii pranali kashee badaloo shakato aanee vistrut tuning bandwidth kashee tayar karoo shakato yaat rus hota. yaa abhyasat done gatancha samavesh hota, parmanand vaparkarte aanee niyantrane, jyanna taee bhramachi sankshipt pradarshane darshavili gelee. abhyasache parinam yaa kalpanela samarthan detat qee emm. dii. emm. aii. chya vaparamule serotoninche nuksan jhalyamule ausipital lobmadhil abhimukhata sanvedanshil neuronsmadhye parshvik avarodh qamee hoto. heey parmanand gatane dakhavun dile qee niyantrananchya tulanet taee bhramachya parimanat jaast vaadh disun aalee. lekhakanni asey mhatale aahe qee kadachit "serotonin heey, julavun ghetana neuronschee sanvedansheelata kitee qamee hote yaat guntalele asate". 445. asey asoo shakate qee, serotonergic karya qamee jhalyamule, anukulananantarchya abhimukhata neuronschya sanvedansheelatet honari ghat aanakhi qamee hote, jyamule techi tivrata vadhate. emm. dii. emm. aii. chaa vapar parshvik pratibandhavar parinam karato aanee serotonin drushya abhimukhata prakriyet bhoomika bajavate yaa kalpanela tyanche sanshodhan samarthan dete.

