
lacosamide

itaranmadhye vimpat yaa brand navane vikale jaanare lacosamide heey eka aushadh aahe jeey aanshik-prarambhiche daure aanee prathamik samanyikrut tonnic-clonic daure yavar upchar karnyasathi vaparale jaate. yacha vapar tondane kinwa antahshira paddhatine keela jaato.
heey samanya aushadh mhanoon upalabdh aahe.
vaidyakeey vapar.
prathamik samanyikrut tonnic-clonic zatkyanchya upcharanmadhye aanshik-prarambhichya zatkyanchya upcharansathi aanee sahayak upcharansathi lacosamide soochit kele jaate.
auph-label vapar.
itar apasmarachya virodhi aushadhanpramanech (aii. dii. ess.), lacosamideche vividh prakarche auph-label vapar asoo shakatat, jyat vedna vyavasthapan aanee mansik aarogya vikaranchya upcharancha samavesh aahe. dvidhruvi vikar, kokenche vyasan, smrutibhransh, nairashya, madhumehi paridhiy neuropathy, fibromyalgia, dokedukhi, uchaki, huntington rog, unmad, ardhashishi, obsessive-compulsive disorder, panic disorder, restless legg syndrome aanee tinituschya vyavasthapanasathi lacosamide aanee itar edscha vapar auph-label keela gela aahe. aii. dii. chya sanyogancha vapar anekada japti qamee karnyasathi keela jaato. aanshik suruvatichya daure, madhumehi neuropathy aanee fibromyalgiasathi monotherapy mhanoon lacosamidechya vaparasathi abhyas suru aahet.
matbhed.
eff. dii. aii. neey garbhadharanechya qa shrenila lacosamide dile aahe. pranyanchya abhyasat garbhatil mrutyu aanee vadhitil kamatarata yaa ghatananchi nond jhaali aahe. manvi garbhadharanedarmyan lacosamidechi chachani jhaleli nahee aanee tee savadhgirine dilee pahije. yavyatirikt, aaichya dudhat lacosamideche visarjan hote qee nahee heey nishchit kele gele nahee.
dushparinam.
aanshik-prarambhiche daure asalelya praudh rugnanmadhye lacosamide samanyatah changlya prakare sahan kele gele. chakkar yene, ataxia, diplopia (duheri drushti), nistagmus, malmal, chakkar yene aanee susti heey sarvat samanyapane bund honyat karanibhoot asalele dushparinam hote. kiman 10 takke rugnanmadhye yaa pratikool pratikriya disun aalya. qamee samanya dushparinamadhye comp, aspasht drushti, ulatya aanee dokedukhi yancha samavesh hoto.
jatharantriy.
samanyatah changle sahan karnare aushadh, malmal, ulatya aanee atisar heey lacosamideche sarvat samanyapane nondavalele jatharantriy dushparinam aahet.
madhyavarti majjasanstha.
chakkar yene hii upcharanshi sambandhit sarvat samanya pratikool ghatana hotee. dokedukhi, tandri, aspasht drushti, anaichhik halchali, smaranshaktichya samasya, dvidha drushti (duheri drushti), thartharane kinwa haat halavane, asthirata, ataxia heey see. aine. ess. chey itar parinam aahet.
mansik.
panic attack; uttejana kinwa aswasthata; chidchid aanee aakramakta, chinta kinwa nairashya; aatmahatya; nidranash aanee unmad; badalaleli manahsthiti; aarogyachi khotee aanee asamanya bhavna. keval 0.3% rugnanmadhye mansopacharasaha lacosamideche manasopacharvishayak dushparinam qamee asalyache disun yete.
hriday v raktavahinyasambandhi.
postural hypotention tasech erythmiacha dhoka asato. yavyatirikt, attrioventricular blockchi shakyata aahe. madhumehi neuropathy asalelya kahee lokanmadhye, lacosamidemule alind tantumay hone aanee alind fuganyache kaaran banalyache vipanananantarche ahwal dekhil aale aahet.
ellergy.
pural aanee pural padalyachya batamya aalya aahet.
ishara deela.
lacosamides upchar suru kelyanantar eka aathvadyapurvich aatmahatyeche vartan aanee kalpana disun aalya aahet aanee bahutek aii. dii. chya vaparas hii pratikool pratikriya aahe. 12 aathvadyanchya vaidyakeey upchar kalavadhichya chachanyanmadhye, 27,863 rugnanmadhye aatmahatyechya kalpananche praman 0.43% hote, tarr placebo-upcharit 16,029 rugnanmadhye 0.24% hote. upchar kelelya pratyek 530 rugnanpaiki 1 rugnanmadhye aatmahatyeche vartan disun aale.
garbhadharanedarmyan.
zebrafish bhrunatil edschya terratogenic kshamateche moolyankan karnyasathi kelelya abhyasat, lacosamidecha terratogenicity nirdeshank lamotrigin, levateracitum aanee ethosuximidepeksha jaast asalyache aadhalun aale. lacosamidechya vaparamule navjat zebrafishmadhye matrenusar vegvegalya vikrutee nirman jhalya.
atipramanat.
atipramanat aushadh ghetalyas konatahi dnyat upay nahee.
aushadhashastra.
pharmacodynamics.
lacosamide heey eka karyatmak amino aaml aahe jeey kamal electroshock japti (mess) chachanimadhye kriyakalap nirman karate, jeey itar kahee antipileptic aushadhanpramanech (aii. eae. dii.) voltage-gated soodiyam vahinyandvare karya karate asey manale jaate. lacosamide heey voltage-gated soodiyam vahinyanchya jalad nishkriyatevar parinam naan karata voltage-gated soodiyam vahinyanche santh nishkriyata vadhavate. heey nishkriyakaran vahini ughadanyapasun rokhate, jyamule krutee kshamata sampavanyas madat hote. carbamazepine kinwa lamotriginsarkhi anek apasmaraniy virodhi aushadhe, nishkriyatetun punarpraptila mandavtat aanee tyamule neuronschee kriya kshamata qamee karanyachi kshamata qamee karatat. nishkriyata keval neuronschya firing action potentialmadhye hote; yacha arth assa qee jalad nishkriyata niyantrit karnari aushadhe sakriy peshinmadhil firing nivadakpane qamee karatat. santh nishkriyata sarkhich asate parantu shekado milisekand kinwa tyahoon adhik kaal sakriy aanee nishkriyata yaa donhisah, voltage gated soodiyam vahinyanche sampoorn avarodhan nirman karat nahee. lacosamidemule heey nishkriyata qamee vidhruvikrut puttle kshamatevar hote. yacha arth assa qee lacosamide keval asha neuronsver parinam karato jeey depolarised kinwa dirgh kalavadhisathi sakriy asatat, jeey epilepsichya kendrasthani asalelya neuronsche vaishishtya aahe. lacosamidechya vaparamule punaravrutti honanya neuronal firingcha pratibandh hoto, hypererexatable neuronal membranesche sthirikaran hote aanee dirghkal vahinyanchi upalabdhata qamee hote, parantu tyacha sharirik karyavar parinam hott nahee. lacosamidemadhye krutichi duheri yantrana aahe. heey copplessin pratisad madhyasth prathine 2 (see. aar. emm. pii.-2) madhye dekhil badal karate, jyamule mendumadhye asamanya neuronal jodani tayar honyas pratibandh hoto.
lacosamidecha prabhav empa, kinet, aine. emm. dii. aii., gaba, gabab kinwa vividh prakarchya dopaminergic, serotonergic, adrenergic, muscarinic kinwa canabinoid receptorsver padat nahee aanee potassium kinwa calcium pravahanna avarodhit karat nahee. lacosamide norpenephrin, dopamine aanee serotonin yasah neurotransmitterche punargrahan niyantrit karat nahee. yavyatirikt, teey gaba transaminasela pratibandhit karat nahee.
purv chikitsalayin sanshodhan.
purv chikitsalayin chachanyanmadhye, apasmarachya pranyanchya pratimananvar lacosamidechya prashasanachya parinamachi chachani 0.63 mii. gra./qii. gra. chya prabhavi matresah (edd. 50), mhanje, japti kriyakalapanchya frings audiogenic seasures (aii. jee. ess.)-sanshayaspad maus modelcha vapar karoon kelee gelee.pii. japticha prasar rokhanyasathi mess chachanicha vapar karoon lacosamidechya parinamache moolyankan dekhil kele gele. undaranmadhye mesamule (edd 50 = 4.5 mii. gra./kilo, mhanje.pii.) aanee under (edd 50 = 3.9 migra/kigra, pii.oo.). purv chikitsalayin chachanyanmadhye, itar aii. dii. saha lacosamidechya sanyojanamule sahakriyatmak anticonvalsant parinam disun aale. lacosamidene pranyanchya aavashyak comp, tardive dyskinesia, schizophrenia aanee chinta yaa pratikrutinvar parinam nirman keela. purv chikitsalayin chachanyanmadhye, murkhanchya upcharanmadhye ess-stereoisomer haah aar-stereoisomerpeksha qamee shaktishali asalyache aadhalun aale.
pharmacokinetics.
nirogi vyaktinmadhye tondawate dile jaate tevha lacosamide jatharantramargatun vegane shoshale jaate. first paas effectmule aushadhacha thodasa bhag nasht hoto aanee tyamule tondawate jawaljawal 100% jaivupalabdhata asate. praudhanmadhye, lacosamidemadhye plazma prathinanche bandhan 15 takkyanpeksha qamee asalyache disun yete, jyamule itar aushadhanshi parasparsanvadachi kshamata qamee hote. tondawate dilyanantar andaje 1 teey 4 tasanantar rakt plazmamadhye lacosamideche praman sarvadhik asate. lacosamideche ardhayushya sumare 12-16 tasanche asate, jeey rugna dekhil enzyme inducer ghet asalyas badalat nahee. parinami, heey aushadh 12 tasanchya antarane divasatoon donada dile jaate. lacosamide mutrapindadware utsarjit hote, 95 takke aushadh mutratoon kadhoon takale jaate. sanyugatil 40 takke ghatak tyachya mool sanrachanepeksha badalat naheet, tarr urvarit nirmulan utpadanat lacosamideche chayapachay asatat. malatoon keval 0.5 takke aushadh kadhoon takale jaate. sayyap2see9, sayyap2see19 aanee sayyap3aii4-madhyasthi demethylation haah lacosamidecha pramukh chayapachay marg aahe.
lacosamidesathy matra-pratisad vakr resheey aanee 800 migra paryantchya tondavatechya matresathi aanee 300 migra paryantchya antahshira matresathi pramanbaddh aahe. lacosamidemadhye aushadh-aushadh parasparsanvadachi kshamata qamee asate aanee soodiyam vahinyanvar karya karananya itar (aii. dii.) aushadhanshi konatehi pharmacokinetic parasparsanvad hott nasalyache aadhalun aale aahe. zenopus" andakoshanmadhye see. aar. emm. pii.-2shhee lacosamidechya bandhanivaril abhyasat spardhatmak aanee vishisht bandhan donhi disun aale. lacosamideche keey. dii. moolya fakt 5 micronometerpeksha qamee asate aanee bii. max. sumare 200 pii. emm./mii. gra. asate. plazmamadhye lacosamidechya vitaranache praman (vhee. dii.) 0.6 ell./kilo aahe, jeey panyachya ekoon pramanachya jawal aahe. lacosamide heey amphiphilic aahe aanee tyamule hydrophilic aahe tarr rakt-menducha adthala paar karnyasathi purese lipophilic dekhil aahe.
rasayanshastra.
lacosamide heey eka pandhare teey halake pivale sfatikeey sanyug aahe. lacosamideche rasayanik naav ("aar")-2-acetamido-"aine"-benzil-3-methoxypropionamide aanee pranaligat naav "aine 2"-acetyl-"aine"-benzil-"oo"-methyl-"dii"-serinamide aahe. lacosamide haah eka karyatmak amino acid renu aahe jyachi panyat aanee dii. emm. ess. oo. madhye uchch vidravyata aahe, phosphet-buffer khaara (pii. bii. ess., pii. etch. 7.5,25°see.) madhye 20.1 mii. gra./miilii. chee vidravyata aahe. yaa renumadhye sahaa firavata yenyajoge bandh aanee eka sugandhi vartul asate. lacosamide 143-144 sase. varr vitalate aanee 760 emm. emm. etch. jee. chya dabane 536.447 sase. varr ukale.
sanshleshan.
1996 madhye lacosamideche pudhil teen-charananche sanshleshan prastavit karnyat aale.
("aar")-2-amino-3-hydroxypropanoic aamlavar acetic enhydride aanee acetic aamlane upchar kele jaatat. utpadanavar pratham 'aine'-methylmorpholine, isobutyl chloroformate aanee benzylamines upchar kele jaatat, tyanantar methyl iodide aanee sylver oxides upchar kele jaatat, jyamule lacosamide tayar hoto.
alikadchya varshant sanshleshanasathi adhik karyaksham marg prastavit kele gele aahet, jyat khaleel goshtincha samavesh aahe.
itihas.
1996 madhye huston vidyapithat lacosamidecha shodh lagla. tyanni asey gruhitak kele qee sudharit amino acid heey apasmarachya upcharanmadhye upcharatmakdrushtya upayukt tharoo shakatat. asha kahee shambhar renunche anek varshant sanshleshan karnyat aale aanee tyanchi undaranmadhye kelelya apasmarachya rogachya pratimanat drukpraroop chachani karnyat aalee. aine-benzil-2-acetamido-3-methoxypropionamide yaa pratimanat atyant prabhavi asalyache aadhalun aale, jaivik kriyakalap visheshtah tyachya aar ananciomermadhye aadhalala.
schwarz farmane parwana dilyanantar heey sanyug lacosamide honar hote, jyane tyacha purv-vaidyakeey aanee prarambhik vaidyakeey vikas purn keela. 2006 madhye schwarz aushadh kharedi kelyanantar, yuu. see. bii. neey vaidyakeey vikas karyakram purn keela aanee lacosamidesathy vipanan manyata prapt kelee. manjurichya velee tyachi krutichi achook yantrana adnyat hotee aanee tyat samavisht asaleli achook amino acidchi uddishte aajahi anishchit aahet.
yuu.ess. ann aanee aushadh prashasanane (eff. dii. aii.) 29 november 2007 roji lacosamidesathy yuu. see. bii. chaa naveen aushadh arj swikarla, jyamule aushadhachi manjuri prakriya suru jhaali. yuu. see. bii. neey european unionmadhye (eae. yuu.) vipanan manjurisathi dekhil arj keela; european aushadh agencyne meey 2007 madhye punaravalokanasathi vipanan arj swikarla.
3 september 2008 roji european unionmadhye yaa aushadhala manjuri denyat aalee. 29 aktoobar 2008 roji americet tyala manjuri denyat aalee. niyantrit padarth kayadyachya anusuchi 5 madhye tyachya sthanabaddal aakshep ghetalyamule lacosamidechya prakashanala vilamb jhaala. eff. dii. aii. neey 22 juuna 2009 roji anusuchi 5 madhye niyukticha tyancha antim niyam jaaree keela.
lacosamideche yuu. ess. paytant 17 march 2022 roji kalbahya jhaale.
aanshik-prarambhiche daure.
lacosamidechi chachani kiman 1300 rugnanchya teen placebo-niyantrit, duheri-andh, yadruchchik chachanyanmadhye karnyat aalee. kharab niyantrit aanshik-prarambhiche daure asalelya vyaktinvar lacosamidechya vegvegalya matranchi parinamkarakta aanee surakshitata nirdharit karnyasathi aayojit kelelya bahu-kendra, bahurashtriy, placibo-niyantrit, duheri-andh, yadruchchik vaidyakeey chachanit, lacosamide heey itar antipileptics vyatirikt, divasala 400 aanee 600 milligramchya matret dilyavar, japtichi varanvarta qamee karnyasathi lakshaniyaritya aadhalale.
paridhiy neuropathy.
madhumehi neuropathy asalelya rugnanchya chhotya chachanimadhye, lacosamidene placebochya tulanet vedna qamee karnyasahi lakshaniy madat kelee. rugnanmadhye 1-3 itar aii. dii. saha lacosamideche sevan changlya prakare sahan kele gele. madhumeh neuropathy asalelya rugnanmadhye, 18 aathvadyanchya upchar kalavadhisah, multy center, double-blind, placebo-niyantrit tappa III chachanimadhye, 400 mii. gra./divasane dilele lacosamide lakshaniyaritya vedna qamee karate asey aadhalun aale.
lahan fiber paridhiy neuropathisathichya eka chhotya (aine = 24) abhyasache dekhil sakaratmak parinam disun aale.
samaj aanee sanskruti.
nave.
lacosamide heey aantarrashtriy gair-malakiche naav (inn) aahe. heey purvi erlosamide, harcoseride, ess. pii. emm.-927 aanee 234037 mhanoon olakhale jaat hote.
lacosamidechi vikri yuu. see. bii. dware vimpat yaa brand navane aanee tivra aushadhanirman sansthandvare motpoli ex. aar. yaa brand navane kelee jaate. pakistanmadhye, jee dware tyache vipanan kele jaate.dii. lacolit mhanoon shodh ghya.
sanshodhan.
aanshik-prarambhichya zatkyansathi monotherapy mhanoon lacosamidechya vaparasathi vaidyakeey chachanya suru aahet. aanshik-prarambhichya zatkyanchya upcharansathi lacosamide sadhyachya antipileptic aushadhanpeksha (aii. dii. ess.) atirikt moolya pradan karato yacha konatahi purava nahee, parantu too surakshitatecha fayda deu shakato. lacosamide, vigabatrin, felbamet, gabapentin, tygabine aanee rufinamide yasah naveen aii. dii. heey carbamazepine, phenitoin aanee valproate yasarkhya junya aushadhanpeksha adhik sahan karnyayogya aanee surakshit asalyache aadhalun aale aahe.