
krutrim pandhya rakt peshi

krutrim pandhya rakt peshi samanyatah padadyane bandhalelya putika asatat jyaa naisargikaritya tayar jhalelya leukocytes rogpratikarak vartanachi nakkal karnyasathi tayar kelya jaatat. aapatkalin rakt sankramanat vaparasathi krutrim laal rakt peshi aanee plateletschya sandarbhat vyapak sanshodhan kele gele asale taree, krutrim pandhya raktapesheenvaril sanshodhan karkarogavar upchar karnyasathi kinwa adhik anukool paddhatine aushadhe denyasathi yajmanamadhye rogpratikarak pratisad vadhavnyavar kendrit aahe. kahee maryadanmule leukocytechi nakkal karananya kanancha mothya pramanavar vapar honyapasoon aanee eff. dii. aii. manjur honyapasoon pratibandh jhaala aahe, tarr krutrim raktachya yaa kshetrasathi adhik sanshodhan vatap kele jaat aahe jyamadhye karkarog aanee itar rogansathi upcharancha eka naveen prakar tayar karanyachi kshamata aahe.
leukocyte shariravidnyan.
shwet rakt peshi (doubleu. bii. see.) mhanoon olakhale jaanare leukocytes vividh prakarat yetat aanee samanyatah jivanu kinwa vishanu sarkhya rogkarak aakramankartyanna tasech karkarograst jhalelya peshinna door thevanyasathi sharirbhar pasaratat. teey pramukhyane keshika pathye, asthimajja aanee lasika vahinyansah sampoorn raktavahinyanmadhye pasaratat. neutrophils, eosynophils, besophils, monocytes aanee lymphocytes heey doubleu. bii. see. chey paach pramukh prakar aahet. tethe leukocytes astitvat aahet jeey prasarit hott naheet parantu tyaeivaji vishisht uutinmadhye rahatat. yamadhye hysteocytes aanee dendritic peshincha samavesh aahe. peshincha prakar aanee vikasachya tappyanusar tyancha aakar samanyatah 8 teey 18 micronometer vyasacha asato. sarasari manvi shariratil ekoon raktapesheenpaiki andaje 1 takke raktapeshi asatat. leukocytes see. dii. 47 aanee see. dii. 45 biomarkerschee abhivyakti rakhatat, jeey itar peshinna teey kaay aahet aanee tyancha naash keela jaau naye heey soochit karatat. dendritic peshinsarkhya peshi janmajat rogpratikarak pranalimadhye guntalelya asatat, tarr lymphocytesarkhya peshi sakriy rogpratikarak pranalicha bhag asatat.
neutrophils.
chemotaxischya yantranedvare, neutrophils samanyatah dahak rasayanik sanketanchya vadhiv sandratepasun srav karananya dahak sthalankade sthalantarit hott asalyache aadhalate. ekada teey jaljalichya thikani pohochale qee, teey itar prakarchya leukocytes sakriy karnyasathi cytokines sodatat. neutrofilsche vishisht chemotaxis vartan hatalalelya neutrofilscha vapar karoon karkarogachya thikananche sthanik lakshyikaran karnyas anumati dete. neutrophils heey rogjanakanche sanrakshn karnare aanee phagocytosis, degranulation aanee bahyakoshikiy sapalyandvare asey sadhya karnare pahile aahet.
eosynophils.
phagocytosis kartana aanee sansargjanya rogjanakanchi sankhya prabhavipane qamee kartana eosynophils neutrofilspeksha kamkuvat asatat. tathapi, vishari prathine asalelya danyanchya muktatedware, vishanuviruddha prabhavi asalelya naskansah, teey kahee parjivi jivanna lakshya karnyat aanee nasht karnyat utkrusht aahet.
besophils.
pramukhyane allergychya pratikriyanmadhye guntaleli, besophils heprin, histamine aanee proteolytic enzymes asaleli daane sodatat. tyanchyat eosinophilsasarkhech parajivivirodhi gunadharm asatat, tasech tii-peshinchi niyamak karye pradarshit karatat aanee itar rogpratikarak peshi kitee pramanat sakriy hotat yavar niyantran thevatat.
monocytes.
ekada monocytes rogjankanchya pradeshat pravesh kelyavar, teey macrofagemadhye vegale hotat jeey phagocytosisdware vishisht rogjanakanche uchchatan karatat. tii-peshinmadhye pratijan sadar karnyat teey mahattvachi bhoomika bajavtat, jeey rogpratikarak pranalila tyaa pratijananchya samparkat aalyanantar savadh sanket detat.
lymphocytes.
lymphocytes pudhe teen mukhya prakaranmadhye vibhajan kele jaau shakate. yamadhye bii-peshi, tii-peshi aanee naisargik ghatak (aine. keey.) peshi yancha samavesh hoto. bii-peshi sakriy hotat aanee naash aanee pachanasathi avanchhit pratijananna bandhanyasathi aanee tagg karnyasathi pratipinde tayar karatat. ekada sakriy jhalyavar, teey tatkal krutisathi pratipinde tayar karoo lagatat, kinwa ekhadya vishisht pratijanapasun dirghkal sanrakshn mhanoon kaam karnyasathi teey memory bii peshi mhanoon sharirat firat asatat. bii-peshi, sahayyak tii-peshi aanee see. dii. 4 + peshi yasarkhya itar peshi sakriy karane, tasech vishanujanya sankramit peshi aanee karkarogachya peshi nasht karane yasah tii-peshinchi anek pramukh karye aahet. aine. keey. peshi janmajat rogpratikarak pranalimadhye guntalelya asatat aanee peshi puttle thet nasht karnyasathi perforin aanee gransimechya sodatidvare rogjankancha naash karatat, itar doubleu. bii. see. chee kriyashilata vadhavanyasathi tii. aine. eff.-aii. sarkhya cytokinesche sodati tasech apoptosisla chalana denanya sanketancha srav karatat. tii-peshinchya ulat, aine. keey. peshi purv uttejan naan deta rogjankancha naash karanyachi karya dekhil karoo shakatat.
itihas.
aapatkalin paristhitit upalabdh asalelya sampoorn raktadanachya kamatarateche nirakaran karnyacha prayatna mhanoon krutrim laal rakt peshi mhanoon krutrim doubleu. bii. see. madhye sanshodhan suru jhaale. 2000 chya dashakapasun vikasit jhalelya krutrim doubleu. bii. see. chaa tyanchya pratyek vaishishtyasah rogpratikarak peshinchya achook pratikrutinchya punarutpadanashi qamee sambandh aahe aanee vastavik rogpratikarak peshinchya aakarache sadhe putkesarkhe kann tayar karnyashi adhik sambandh aahe jeey karye karnyas aanee prabhavi pramanat jaivik rogpratikarak peshinchya sharirik vaishishtyanchi nakkal karnyas saksham aahet. cytotoxic sanyuge sodane aanee phagocytosis karanyachi kshamata hii visheshtah krutrim doubleu. bii. see. madhye samanyatah nakkal kelee jaanari mukhya yantrana aahe.
sadya pragati.
leukosomes.
leukosomes heey lipid bilayer vesicals aahet jyat antarbhut prathine asatat jee naisargikaritya tayar jhalelya leukocytes padadyamadhye aadhaltat. leukosomeche kann leukocytessarkhech yantrik aanee sharirik guna pradarshit karatat, tarr liposomal utpadan aanee upcharatmak prashasanachya fayadhyancha dekhil fayda hoto. leukosomes pradhanyane inn vitro aanee inn vivo yaa donhi prakarchya sooj asalelya endothelial uutinna lakshya karatat asey darshavile gele. teey samanyatah ekhadya jivakadun rogpratikarak peshi gola karoon, bahutekda undarankadun aanee plazma puttle vagalata serve mool ghatakanchi vilhewat lavoon tayar kele jaatat. ekada plazma padada vegala jhalyavar, kanala ichchit vishayachya leukocytesarkhich rachana denyasathi prathinanni samruddha kele jaate aanee glucocarticoidsarkh upcharatmak padadyamadhye virghalananya sanyuganni bharalele asate jeey dahak-virodhi guna pradarshit karatat. jevha dexamethasone bharalele asate, tevha leukosomes jaljalichya thikani jamaa houu shakat asat aanee dahak-samarthak chinhakanchi abhivyakti qamee karoo shakat asat. itar abhyasanmadhye asey aadhalun aale aahe qee leukosomes dahak-virodhi janukanchi abhivyakti vadhavat, dahak rogansathi upchar paddhati mhanoon vachan darshavitana, dahak-samarthak janukanchi abhivyakti qamee karatat. eka abhyasat, murine modelmadhye injectiondware doxorubicinne bharalelya leukosomesne virghalalelya parisanchari doxorubicinpeksha stun aanee melanoma tumourchya vadhis adhik prabhavipane pratibandh keela. dusarya abhyasat doxorubicine bharalelya liposomes aanee leukosomes yaa donhimadhil upcharatmak vartanatil farkanchi tapasani kelee aanee asey aadhalale qee liposomeschya vipareet bharalelya leukosomesne swatahla aaspaschya peshinmadhye vitromadhye adhik changlya prakare samavisht kele aanee doxorubicinsathi eka prabhavi aushadh sanch mhanoon kaam kele.
leukopolymersomes.
leukopolymersomes heey polymer block-aadharit nanoe kann aahet jeey leukocytes chikat gunanchi nakkal karnyat utkrusht aahet, visheshtah mool leukocytesmadhye aadhalanaya selectins aanee integrinsche bandhan. polymersomes samanyatah polly (lactide), pii. see. ell., pii. tii. emm. see., polly (ell-glutamic acid) aanee dextran yasarkhya jaivavighatanshil polymerpasoon tayar kele jaatat. keval golakar aakar gheu shakananya lipid nanoparticles ulat, polymersomes disk, ellipsoids aanee tubesarkhya vividh aakaranmadhye tayar kele jaau shakatat. patal puttle punarbharan aanee thet injection yasarkhya paddhatinmule badalatya aakarache polymersomes tayar hotat. polymerisation prerit swayam-assembly aanee flash nanoprecipitation yasarkhya itar aakarachya babatit adhik susangat utpadan paddhati aahet. heey kann phospholipid putkepeksha adhik sthir asatat, jyat vighatan honyapurvi taana jaast asato. heey visheshtah upayukt aahe kaaran heey jaljalichya thikani, jethe mothya pramanat katarane shakti asatat, tethe chikatavanyas anumati dete. daat padade aanee polymersomschya hydrophobic sakhalyanchi vyavastha adhik sthirata aanee sharirat aushadh dharan karate. polymersomscha prushthbhag sahsanyojak aanee gair-sahsanyojak sanyugman rasayanshastra yaa donhinshi susangat aahe jyacha vapar vishisht ootee aanee pesheey prushthbhaganna lakshya karnyasathi keela jaau shakato. 2003 salchya suruvatichya abhyasane 'pii. ell. jee. aii. microspheres' tayar karanyachi eka paddhat vikasit kelee jee dahak-virodhi aushadhanni bharali jaau shakate, jaljalichya thikananna chikatoon rahoo shakate aanee selectin aanee legand rasayanshastradvare bharalele aushadh sodu shakate. sankalpanet yaa polymersomschya suruvatichya aavrutya aahet. tumour pratijananni bharalele asatana polymersomes pratijan upasthit karananya peshinchi nakkal karoo shakatat, jyamule rogpratikarak shakti majboot houu shakate aanee nanovaxin mhanoon prabhavipane karya karate. leukopolymersomscha daah aanee karkarogavar upchar mhanoon vapar karanyachi kshamata asate.
leukolasarkhe vahak.
leukolasarkhe vahak heey nanopaurus siliconpasoon tayar kelele nanoe kanancha eka prakar aahe jeey baher kadhalelya mool leukocyte pataladvare aachchhadit kele jaate. sampoorn raktat nanoparticles parisancharan vadhavanyasathi cellular membraincha vapar karnyachya sankalpanecha purava mhanoon abhyas kelya jaananya pahilya krutrim pandhya raktapesheenpaiki heey kann hote. abhyasatoon asey disun aale aahe qee karkarogasathi chemotherapy aushadh vitaranat leukolasarkhe vahak vishisht fayade detat. yache kaaran asey qee leukolasarkhe vahak visheshtah tumour endotheliumshi bandhanyachi kshamata thevatat.
nanoghosts.
nanogost heey nanocysed putke asatat jyat nivadalele aushadh vitaran payload asate jeey kadhalelya leukocyte padadyamadhun tayar kele jaate aanee peshi peshidravya samagri kadhoon takali jaate. rogpratikarak pratisad milanyachi shakyata qamee karnyasathi tasech raktatil kananche parisancharan vadhavanyasathi jaivik patalancha vapar rogpratikarak pranalitil kananna zakoon thevanyache kaam karato. cytosol kadhanyasathi peshinche samarupikaran karoon aanee nantar rikamya peshi patalanna soniket karoon 100 teey 200 nm vyasachya darmyan nanogost tayar karoon teey tayar kele jaatat. laal raktapesheenmadhun nanoghost tayar karnyasathi vaparale jaanare padade sumare 120 divas prasarit hotat aanee phagocytotic peshi talhtat asey disun aale aahe. neutrophil aadharit nanoghost neutrophilchi chemotaxis kshamata jaljalichya thikani rakhoon thevatat, jyamule tumourche lakshyikaran karnyas protsahan milate. aine. keey. aadharit nanoghost metastatic karkarog lakshyit vartan darshavtat. ekpeshi aadharit nanoghost heey tumourchya sookshm vatavaranat ghuskhori karnyasathi prabhavi aahet. messenkimal stame selpasoon vyutpann nanoghost karkarog lakshya karnare gunadharm pradarshit karatat.
peshi sadar karnare krutrim pratijan.
krutrim pratijan sadar karananya peshi (aapc) uttejak receptor legands polystyrene manee asatat. cytokinesne bharalele aii. aii. pii. see. heey keval costimulatory legands asalelya kananpeksha tii-peshinna jaast pramanat uttejit karatat asey aadhalun aale aahe.
maryada.
krutrim doubleu. bii. see. chya vikasatil pramukh maryada mhanje tantradnyanache vaidyakeey manyata aanee vaparamadhye bhashantar karane. itar maryadanmadhye krutrim doubleu. bii. see. tayar karnyasathi aavashyak tantradnyanachi upalabdhata, utpannatil parivartansheelata aanee pramanit vaidyakeey vaparasathi aavashyak kann shuddha karnyat adachani yancha samavesh hoto. kahee abhyasanmadhye asehi aadhalun aale aahe qee heey kann nakalatpane itar uutinna lakshya karoo shakatat jeey anyatha nirogi aahet. upcharanchya vitaranat kahee adchaninna samore jaave lagate, kaaran tyaa jalad prashasanamule pranaligat dushparinam houu shakatat, tarr khoop mand ritine sodane qamee prabhavi tharel. polymersomeschi eka mothee maryada mhanje polyethylene glycol aanee polly (lactic-qoo-glycolic acid) sarkhya nivadak polymerna eff. dii. aii. neey vaidyakeey vaparasathi manyata dilee aahe. nanogost kinwa adhik samanyatah puttle-lepit nanoparticles, tyaa peshinmadhye maryada anubhavtat qee tyanchya patalanmadhye prathinanchi vegvegali matra asel, jyamule tyaa utpadananmadhye parivartansheelata aanee sthiratecha abhav nirman hoil. nanoghostchya biomimatic karyasathi aavashyak asaleli puttle prathine utpadan aanee sathavan prakriyet vikrut houu shakatat assa dhokahi aahe. ekandarit, parinamkarakta aanee surakshitata tapasanyasathi yaa biomimatic upayanvar adhik abhyas karane aavashyak aahe.