daunorubicin

donorubicin, jyala donomycin asehi mhanatat, heey karkarogavar upchar karnyasathi vaparale jaanare chemotherapy aushadh aahe. visheshtah yacha vapar tivra myeloid leukemia (aii. emm. ell.), tivra lymphoblastic leukemia (serve), dirghakalin myelogenous leukemia (see. emm. ell.) aanee kaposi sarcoma yasathi keela jaato. heey shiremadhye injectiondware dile jaate. liposomal donorubicin mhanoon olakhale jaanare liposomal formulation dekhil astitvat aahe.
samanya dushparinamadhye cases galane, ulatya hone, asthimajja dabane aanee tondachya aateel bhagachi jaljal yancha samavesh hoto. itar gambhir dushparinamadhye hridayrog aanee injectionchya thikani uutincha mrutyu yancha samavesh hoto. garbhadharanedarmyan vaparlyane garbhala haanee pohochu shakate. donorubicin heey aushadhachya anthracycline kutumbatil aahe. heey topoisomerase II chey karya rokhoon kahee pramanat karya karate.
1979 madhye americet vaidyakeey vaparasathi donorubicinla manyata denyat aalee. teey jaagtik aarogya sanghatanechya aavashyak aushadhanchya yadeet aahe. heey moolatah 'streptomyces' prakarchya jivanunpasun vegale kele gele hote.
vaidyakeey vapar.
heey shariratil karkarogachya peshinchi vaadh mandavate kinwa thambavate. upchar sahasa itar chemotherapy aushadhansah (jase qee citerabine) ekatra kele jaatat aanee tyache prashasana arbudacha prakar aanee pratisadachya pramanat avalambun asate.
aii. emm. ell. chya upcharanmadhye tyachya pramukh vaparavyatirikt, neuroblastomachya upcharansathi dekhil daunorubisinacha vapar keela jaato. dirghakalin myelogenous leukemiachya blastic tappyavar upchar karnyasathi itar chemotherapy agents donorubicincha vapar keela gela aahe.
doxorubicin, epirubicin aanee idarubisinachya ardh-sanshleshit utpadanasathi prarambhik samagri mhanoon dekhil donorubicincha vapar keela jaato.
krutichi yantrana.
doxorubicinpramanech, donorubicin heey macromolecular biosynthesische aantarsanchalan aanee pratibandh karoon dii. aine. aii. shhee sanvad sadhate. heey topoisomerase II yaa enzymechya pragatila pratibandhit karate, jeey pratilekhanasathi dii. aine. aii. madheel supercoilna shithil karate. donorubicin heey pratikrutisathi dii. aine. aii. sakhali tutalyanantar topoisomerase II sankul sthir karate, dii. aine. aii. duheri helics punha seal honyapasoon rokhate aanee tyadvare pratikrutichi prakriya thambavate.
dii. aine. aii. laa bandhalyavar, dunomycin intercalates hote, aanee tyache dunosamine avashesh kirkol khambyakade nirdeshit kele jaatat. 5 'bajula aii/tii bases jodidware farasbandi kelelya done shejaril jee/see bases jodyanna tyachi sarvoch pasanti aahe. chrystallographivaroon asey disun yete qee donomycin 8° chaa sthanik unwinding coone aanee shejarchya aanee aanee shejaril bases jodyanchya itar sanrachanatmak vyatyayanna prerit karate.
heey aantarkramikaranantar chromatinemadhun histone baher kadhanyas dekhil pravrutt karoo shakate.
itihas.
1950 chya dashakat, eka italian sanshodhan company, farmitaliya sanshodhan prayogshalanni maatee-aadharit sukshmajivanpasun karkarogvirodhi sanyuge vegale karnyasathi eka sanghatit prayatna suru keela. apulia yetheel 13 vya shatkatil killa castell dell montechya sabhovatalachya bhagatoon maticha namuna vegala karnyat aala. laal rangdravya nirman nirman "streptomysis pusetius" chaa eka naveen prakar vegala karnyat aala aanee yaa jivanupasun eka pratijaivik tayar karnyat aale jeey murine tumerviruddha changli kriyasheel asalyache aadhalun aale. french sanshodhakanchya eka gatane ekach velee samaan sanyug shodhale asalyane, donhi gatanni sanyugala daunorubicin asey naav dile, jyat 'dauni' heey naav jodale gele, eka purv-roman jamaat jee italichya tyaa bhagat vyapali hotee jithe sanyug vegale hote, french shabd rubi, 'rubis' saha, rung varnan karate. 1960 chya dashakat vaidyakeey chachanya suru jhalya aanee yaa aushadhala tivra leukemia aanee lymphoma yanchyavar upchar karnyat yash midale.
tathapi, 1967 paryant, heey olakhale gele qee daunorubicin hrudayatil pranghatak vishaktata nirman karoo shakate.
2015-16 madhye, ohayo steet universitychya eka chamoone heey dakhavun dile qee, vishanujanya dnachya strandmadhye kaljipurvak ferfar karoon, guntaguntichya folds origami rachana keval 10 minitant tayar kelee jaau shakate. avishvasaniyapane, yaa rachana keval 100 nanometerchya aahet-jyaa manvi kesanchya rundipeksha 1,000 putt lahan aahet. yaa chhotya shenganmadhye donorubicinche lahan praman gundalale jaau shakate, jeey nantar leukemia peshi-bharalelya vatavaranat sodale jaau shakate."
prashasanacha marg.
donorubicin keval jalad antahshira otanyat dile pahije. heey snayunchya aat kinwa tvachekhali deu naye, kaaran yamule vyapak uutinche necrosis houu shakate.
heey kadhihi intrathecal paddhatine (pathichya kanyat) dile jaau naye, kaaran yamule majjasanstheche mothya pramanat nuksan hoil aanee mrutyu houu shakato. drushtipatalatil vilgikaran shastrakriyenantarchi eka samanya guntagunt, proliferative vitroretinopathy rokhanyasathi daunorubisinacha intravitrial (dolhyachya aat) vapar keela gela aahe, parantu too prabhavi asalyache aadhalun aalele nahee aanee yaa velee itar konatyahi netravishayak hetunsathi vaparla jaat nahee.

