ushnatechya dhakkyacha pratisad

ushma shock pratisad (etch. ess. aar.) haah eka peshi tanav pratisad aahe joou vadhalele tapman, oxidative taana aanee judd dhatoo yasarkhya tanavamule tanavamule prathinanvaril nakaratmak parinamancha samna karnyasathi aanvik cheparonchi sankhya vadhavato. samanya peshimadhye, proteostasis (prathine homeostasis) rakhane aavashyak aahe kaaran prathine heey peshiche mukhya karyatmak ghatak aahet. anek prathine tyanchi jaivik karye karnyasathi prathine dumadane mhanoon olakhalya jaanarya prakriyet paribhashit sanrachana ghetat. yaa sanrachananmadhye badal kelyas, gambhir prakriyanvar parinam houu shakato, jyamule peshinche nuksan kinwa mrutyu houu shakato. ushma shock pratisad tanavakhali ushma shock prathinanchya (etch. ess. pii.) abhivyaktila pravrutt karnyasathi vaparla jaau shakato, jyapaiki anek aanvik chepron aahet, jeey prathinanchya chukichya dumadanyala rokhanyasathi kinwa ulat karnyas madat karatat aanee yogya dumadanyasathi vatavaran pradan karatat. 
prathine dumadane heey aadhich aavhanatmak aahe kaaran gardichya antakoshiy jaaget jethe aniyamit parasparsanvad udbhavu shakatat; jevha paryavaraniy tanatanav prathine vikrut karoo shakatat aanee aanakhi mool nasalele dumadane houu shakate tevha teey adhik katheen hote. jarr molecular cheparonche kaam chukiche dumadane rokhanyasathi purese nasel, tarr proteosome kinwa autofagidware prathinanche vighatan kele jaau shakate jenekarun konatehi sambhavya vishari sanch kadhoon takale jaau shakatat. chukichya patavar gundalaleli prathine, tapasali naan gelyas, ektrikaran houu shakate jeey prathinanna tyachya yogya rachnet jaanyapasun rokhate aanee akheris plake tayar honyas karanibhoot tharate, jeey vividh roganmadhye disu shakate. etch. ess. aar. dware prerit ushnatecha dhakka denari prathine alzheimer, huntington kinwa parkinson rogasarkhya samanya neurodegenerative roganshi sambandhit prathinanche ektrikaran rokhanyat madat karoo shakatat.
ushnatechya dhakkyachya pratisadacha samavesh.
paryavaraniy tanatanavanchya parichayasah, peshi proteostasis rakhanyas saksham asane aavashyak aahe. yaa hanikarak paristhitinna tivra kinwa dirghakalin adhinata proteomala sthirata denyasathi cytoprotective pratisad dete. etch. ess. pii. ess. (udaa.jee. etch. ess. pii. 70, etch. ess. pii. 90, etch. ess. pii. 60 ii.) samanya paristhitit upasthit asatat parantu ushnatechya tanavakhali, teey pratilekhan ghatak ushnata dhakka ghatak 1 (etch. ess. eff. 1) dware niyantrit kele jaatat. prushthavanshiy pranyanmadhye (etch. ess. eff. 1-4) chaar vegvegale pratilekhan ghatak aadhaltat, jethe etch. ess. pii. ess. chey mukhya niyamak etch. ess. eff. 1 aahe, tarr σ32 haah 'eae' madheel ushma shock pratilekhan ghatak aahe. kolai."jevha dii. aine. aii. shhee bandhalele nasate, tevha etch. ess. eff. 1 monomeric sthiteet asate jithe teey nishkriy asate aanee chaprondware nakaratmakpane niyantrit kele jaate. jevha taana yeto, tevha heey chepron vikrut prathinanchya upasthitimule sodale jaatat aanee etch. ess. eff. 1 madhye vividh sanrachanatmak badalanmule teey anoo sthanikikaranatun jaate jithe teey trimitikaranadvare sakriy hote. etch. ess. pii. emm. aar. aine. aii. chey pratilekhan sakriy karnyasathi naveen trimiteey etch. ess. eff. 1 heey vegvegalya etch. ess. pii. chya pravartak kshetranmadhye asalelya ushma shock ghatkanshi (etch. ess. eae.) bandhale jaeel. emm. aar. aine. aii. chee akheris pratilekhan kelee jaeel aanee tyat niyantrit etch. ess. pii. ess. samavisht asateel jeey hatacha taana qamee karoo shakatat aanee proteostasis punarsanchayit karoo shakatat. etch. ess. eff. 1 epigenetic badalandware etch. ess. pii. ess. chya abhivyaktiche niyaman dekhil karel. etch. ess. ess. aar. akheris qamee hoil kaaran etch. ess. eff. 1 tyachya monomeric swarupat parat yeil, jeey etch. ess. pii. 70 aanee etch. ess. pii. 90 saha sanlagnata aanee anuvadanantarchya atirikt badalandware nakaratmakpane niyantrit kele jaeel. etch. ess. aar. keval etch. ess. pii. ess. chya pratilekhan patali vadhavnyamadhye guntalele nahee; itar pailunmadhye emm. aar. aine. aii. madheel truti rokhanyasathi tanav-prerit emm. aar. aine. aii. sthirata aanee chukiche putt padane rokhanyasathi anuvadadarmyan vardhit niyantran yancha samavesh hoto.
aanvik capron.
aanvik cheparonla samanyatah prathine mhanoon sambodhale jaate jeey itar prathinanshi sambandhit asatat aanee antim sthiteet nasatanahi sthanik sanrachaneparyant pohochanyas madat karatat. capron tyanchya tharala bandhatat (i.eae. eka vishisht karya karnyasathi aii. tii. pii.-aadharit paddhatine chukiche putt kelele prathin). prathinanchya ektrikaranachya sandarbhat ughad jhalele hydrophobic avashesh hii eka mothee samasya aahe kaaran teey ekmekanshi sanvad sadhu shakatat aanee hydrophobic parasparkriya tayar karoo shakatat. avasheshanna bandhun kinwa prathine yogyaritya dumadanyasathi "surakshit" vatavaran pradan karoon heey ektrikaran rokhane heey sheparonsache kaam aahe. rogpratikarak pranalila roggrast peshi olakhanyas madat karnyasathi peshinchya prushthbhagavar prathinanche (kinwa peptides) tukade sadar karnyat ushmashka prathine dekhil bhoomika bajavtat asey manale jaate. etch. ess. aar. madhye samavisht asalelya pramukh etch. ess. pii. madhye etch. ess. pii. 70, etch. ess. pii. 90 aanee etch. ess. pii. 60 yancha samavesh hoto. chapronmadhye etch. ess. pii. 70 aanee etch. ess. pii. 90 samavisht asatat tarr etch. ess. pii. 60 heey chapronins manale jaatat.
etch. ess. pii. 70 chapron kutumb hii peshinmadhil mukhya etch. ess. pii. pranali aahe, jee anuvad, anuvadanantar, ektritanna pratibandh aanee ektrit prathinanchya punha ghatt honyat mahattvachi bhoomika bajavate. jevha navjat prathinanche bhashantar kele jaat asate, tevha etch. ess. pii. 70 heey prathinanchya hydrophobic pradeshanshi jodale jaau shakate jenekarun bhashantar purn hoiparyant sadosh parasparkriya rokhata yeil. anuvadanantarche prathinanche dumadane asha chakrat hote jethe prathine sheparonmadhun bandhali jaatat/sodali jaatat jyamule hydrophobic gatanna daphan karata yete aanee velevar dumadanyasathi aavashyak asalelya urjevar maat karnyat madat hote. etch. ess. pii. 70 hii uparokt yantranecha vapar karoon prathinanche ektrikaran qamee karnyat bhoomika bajavate; chapron ughad jhalelya hydrophobic avasheshanshi bandhale jaeel aanee prathinanche anshatah kinwa purnapane pruthakkaran karel, jyamule etch. ess. pii. 70 yogya refoldingmadhye madat karel. jevha prathine punha patnyachya palikade asatat, tevha etch. ess. pii. 70 heey sambhavya vishari samuhanna proteezomdware kinwa autofagidware adhogatisathi nirdeshit karnyat madat karoo shakatat. etch. ess. pii. 90 heey refolding kinwa prathinanchya sandarbhat etch. ess. pii. 70 chya samantar asatat aanee prathinanchya safsafaimadhye vaparale jaatat. done etch. ess. pii. madheel eka farak mhanje etch. ess. pii. 90 chee prathine ughadya parantu sthir sanrachanet thevanyachi kshamata joparyant signalmule prathine sthanantarit hott naheet aanee tyanche dumadane purn hott nahee.
kadhikadhi, etch. ess. pii. 70 prathinanna tyachya antim 3-dii sanrachaneparyant pohochanyat prabhavipane madat karoo shakat nahee; mukhya kaaran mhanje dumadanyasathiche thermodynamic adthale heey chapronla purn karnyasathi khoop jaast asatat. aantarkoshikiy jaaga khoop gardichi asalyamule, kadhikadhi prathinanna itar prathinanmadhil aniyamit parasparkriya rokhanyasathi vegalya jaagechi aavashyakta asate, jee chapronins kinwa etch. ess. pii. 60s dware pradan kelee jaate. etch. ess. pii. 60 heey nalichya aakarache asatat aanee prathinanchya hydrophobic avasheshanshi bandhanyasathi yogya asatat. ekada eka topi chaproninshi jodali gelee qee, prathine nalichya aat hydrophobic kosalanyane mukt hotat aanee sthir rachaneparyant pohochatat. ekada topi kadhoon taklyanantar, prathine ektar yogyaritya dumadali jaau shakatat aanee tyache karya karnyasathi pudhe jaau shakatat kinwa jarr tee ajunahi achookpane dumadali gelee nasel tarr etch. ess. pii. kadey parat jaau shakatat. heey chepron ektrikaran kadhoon taknyasathi aanee prathinanchya dumadanyala lakshaniy gatee denyasathi karya karatat.
shodh.
ushnatechya dhakkyachya pratisadacha shodh italiche janukshastradnya ferrucio ritosa yanna deela jaato, jyanni "drosophila" chya politin gunasutransaha kaam kartana ushnatechya samparkat yenyachya pratisadat gunasutra "puffs" navache badal pahile. tyanchya swatachya vruttanusar, prayogshaletil ushmayan yantratil nakalat vadhalelya tapmanacha haah aakasmik parinam hota. 1962 madhye nondavalelya ritosachya nirikshananche nantar varnan 'januk kriyakalapanvar thet karya karnara pahila dnyat paryavaraniy taana' asey kele gele, parantu suruvatila tyancha mothya pramanat ullekh keela gela nahee. 1970 chya dashakat yaa nirikshananche mahatva adhik spasht jhaale, kaaran hershell kechya prayogshalet ushmashka prathinancha eka vegala varg sapadala. michel aanee ushnata shock pratisad itar jivanmadhye nondavale gele aanee sarvatrik mhanoon olakhale jaau lagale.

