kull vargikaran vargikaran

sendriya rasayanshastratil vendor taxol ekoon sanshleshan heey 1997 madhye prakashit jhalelya stanford vidyapithatil paul vendarchya gatadware kelelya taxol ekoon sanshleshanache (aajparyantchya sahaa paiki eka) varnan karate. yaa sanshleshanat holton taxol ekoon sanshleshanashi barech samya aahe kaaran heey eka resheey sanshleshan aahe jeey a, b, c, d kramane ringchya bandhkamasah naisargikaritya naisargikaritya sanyugapasun suru hote. qamee vel chalavanyacha prayatna andaje 10 10 qamee asato. 
yaa margane taxol tayar karnyasathichya kachchya malamadhye verbenon, prenyl bromin, elil bromide, propiolic acid, gillman abhikarmak aanee ashenmosarche meeth yancha samavesh hoto.
aii. bii. ring sanshleshan.
taxol sanshleshan yojana 1 madheel terpin verbenon 1 pasoon suru jhaale, jeey naisargikaritya aadhalanare α-pininche auxidation utpadan aahe aanee ring a tayar karate. ring beechya nirmitichi suruvat pandant methyl gut protonchya potassium "turt"-butoxidechya amurtatesaha jhaali (sanyugmit aayan tayar hoto) tyanantar preneal bromide 2 madheel bromin anooche nucleophilic visthapan houn dyen tayar hote. preneal gatache ozonolysis (antargat duheri bandhapeksha adhik electronyukt) tayar aldehyde 4, jeey isomerization kinwa chrysanthenone 5 chya photoriarangementner, propiolic acid 6 chya ethyl esterchya lithiyam meethasah (ldadware) pratikriya dilee gelee, jee nantar nucleophilic vyatirikt alcohole 7 madhye. heey sanyug vegale jhaale nahee parantu trimethylacylil chlorides sileel ethermadhye sthiteet adakale. pudhil tappyat, eka geliamine, jeey nucleoxide sanyugma gatadware, 10 madhye, eka auxidialetic sanyugmadvare, eka auxidialetic samoohadvare, eka auxidialetic samoohadvare, eka auxidialetic samoohadvare, aanee nantar eka auxidialetic samooh 13 madhye acyloin gut keey. emm. dii. ess. aanee davis oxaziridindware sadar karnyat aala (yaa pranalichya dusarya vaparasathi holton taxol ekoon sanshleshan pahaa) aanee tyacha hydroxyl gut ester gatasah lithiyam aluminium hydridedware tetrol 14 madhye qamee karnyat aala. shevati, prathamik alcohole gatala triol 15 madheel sambandhit cylilchloride aanee imidazoldware "turt"-butyldemethylacylil ether mhanoon sanrakshit karnyat aale.
aale bhagat (yojana 2) prakriya ajunahi aaa aanee buub ringjapurati maryadit aahet. pii. pii. tii. ess. saha pratikriya mhanoon triol 15 madhye adhik snrakshak gut jodale gele aanee 2-methoxypropine acetonide 16 dete. yaa tappyavar ring aii madheel duheri bandh "emm"-see. pii. bii. aii. saha epoxidise keela gela aanee soodiyam carbonetche epoxide 17 madhye aanee dabcone suru kelelya grobe fragmentation (holton prayatnat dekhil upasthit) alcohole 18 madhye aii. bii. ring system ughadali, jee vegali navhati parantu trisopropylsil triflated aanee 2,6-lutidines tipa silil ether 19 mhanoon sanrakshit hotee. see 1 sthitiche pudhil auksidikaran phosphite ester, pii (oity) 3 aanee majboot bases qoo "tii"-buu, aanee oxygenche alcohole 20 madhye jhaale (stereochemistry heey kundichya aakarachya aii. bii. ringdware niyantrit kele gele aanee akhand bahirmukh dishene hydroxylation hote), prathamik alcohole gatala methanolmadhil amonium chlorides diol 21 madhye sanrakshit kele gele aanee done ghat pratham nabh 4 teey triol 22 aanee nantar hydrogen vayoo aanee crabtreeche utprerak triol 23 detat. yaa sthitee trimethylacylil chloride aanee pyridine 24 aanee nantar triphosgene 25 neey sanrakshit kelya gelya jenekarun prathamik alcohole gatala 26 pisidware aldehydemadhye auxidation sulabh hoil.
see ring sanshleshan.
pudhil bhagane eldehyde 26 pasoon suru honari see ring tayar kelee, jee eka carbon anoodvare methoxymethylenasphinephalphiphine (yojana 3) saha whittig abhikriyemadhye 27 paryant vistarit kelee gelee. dioxenmadhye patal hydrochloric aaml aanee soodiyam aayodaidware acetonide gut kadhoon taknyat aala aanee parinami diol 28 madheel eka hydroxyl gut trithylacylil ether (tess) 29 mhanoon sambandhit silil chloride aanee pyridines sanrakshit karnyat aala jyamule urvarit hydroxyl gatatil dishe-martin periodinens keaton 30 madhye auxidation shakya jhaale. eschenmosarchya mithachya pratikriyene eka methylene gut (taxolchya chaukatit chaukatit eldehydechya alfa sthiteet 31 varr thewala aanee pudhil pratikriyene (ajunahi abhav) abhav) aanee aanee heey zinkchya madatine (2) chloride, jyane carbonate gatavar hallah karnyapasoon grignardla rokhale, aanee alcohole 32 madhye nucleophilic jodanimadhye elil bromideche grignard abhikarmak mhanoon sadar kele. navyane tayar jhalelya alcoholche sanrakshn bomb ether 33 mhanoon bombcle aanee aine, diasopropylathelamine karnyat aale. amonium fluorides tess sanrakshn gut kadhoon taklyanantar, 34 madheel carbonate gatala phenylithiumchya krutidvare hydroxybenzoate gatamadhye aanee duyyam alcohole acetic enhydride aanee dii. maps sthit pratikriyedvare acetate 35 madhye rupantarit kele gele. pudhil tappyat acyloin gatane 36 tayar tayar trizabicyclodacine (itar amine kshar ayashasvi) saha abhikriyedvare tyachya sthananchi adlabadal kelee aanee antim tappyat ring seeche ring closure heey elil gatatil ozonolisisdware 37 aanee 4-pyrolydenopyridines eldol abhikriyedvare 38 paryant purn kele gele.
dii ring sanshleshan.
antim bhagamadhye 38 madheel alcohole gatachya sanrakshanapasun suru suru aukzeten ring deechya bandhkamavar charcha karnyat aalee (yojana 4). 39 heey trock alcohole mhanoon 2,2,2-trichloroethyl chloroformate aanee pyridines. obom gatala teen tappyanmadhye bromin gatane badalleh hydrochloric aaml aanee soodiyam iodides 40 paryant sanrakshn, messile chlorides 41 paryant macillation, dii. mapp aanee pyridine aanee lithiyam bromides sanrachanechya ulthapalathisah nucleophilic pratisthapan aanee bromide 42 saha nucleophilic pratisthapan. kaaran ausmiyam tetroxides diol 43 madhye alkin gatache auxidation benzoate gatachya avanchhit sthalantarasaha hote, heey paul imidazoles 44 mhanoon purn karnyasathi ghenyat aale. done atirikt pratikar aavashyak hoteh triphosgenes carbonate ester 45 mhanoon diolche sanrakshn aanee 47-auxite ringla pratyaksh bund karnyachya tayareet benzoate gatala (keey. see. aine.) alcohole 46 paryant kadhoon takane, takane antim tappyat trutiyak alcohole 48 madhye acelated karnyat aale, tipa gut 49 madhye kadhoon taknyat aala aanee benzoate gut 50 madhye punha sadar karnyat aala.
ojima lactum 51 chee shepatichi bharr tapshilvar ughad karnyat aalee nahee parantu shevati itar prayatnanpramanech anek anek taxol 52 tayar karnyat aala.

