haemaglutinin

aanvik jivashastrat, haemaglutinins (kinwa british ingrajimadhye haemaglutinin) (greek, 'rakt' + lattin, 'gond' pasoon) heey 'paramixoviridae' kutumbatil vishanundvare tayar kelele receptor-binding membrain fusion glycoproteins aahet. raktatil rakt peshinvaril receptorsna bandhanyasathi haemaglutinins jababdar asatat, jyamule vishanusambandhi sanlagnata aanee sansarg suru hoto. jevha eka peshivaril pratipinde itar peshinshi bandhali jaatat, jyamule guthalya jhalelya peshinche aakarheen ektrikaran hote, tevha laal peshinche ektrikaran hote.haemaglutinins heey poshak laal raktpeshinchya prushthbhagavaril siyalik aaml asalele peshi-prushthbhagavaril glycoconjugates qamee aakarshanasah olakhatat aanee tyancha vapar poshak peshinchya endosome pravesh karnyasathi karatat. endosome, haemaglutinins 5-6.5 chya phvar sakriy hotat, jyamule sanrachanatmak badal hotat jyamule fusion peptideware vishanuche jodane shakya hote.
ektrikaran aanee haemaglutininscha shodh vishanushastradnya george keey. yanni lavala. 1941 madhye alfried gotschockne 1957 madhye siddha kele qee haemaglutinins peshi-puttle glycoproteins aanee glycolypidschya karbodakanchya bajuchya sakhalyanvaril siyalik acidshee jodoon vishanula yazman peshishi jodatat.
rachana.
haemaglutinins hii lahan prathine aahet jee vishanuchya padadyachya prushthbhagavarun 135 Â lambichya spikechya rupat 30-50 Â chya vyasasah prakshepit hotat. pratyek spike teen samaan monomer upaghatakanni banalela asato, jyamule prathine samarupi banatat. heey monomers heey done glycopeptides, etch. aii. 1 aanee etch. aii. 2 pasoon tayar hotat aanee done diasulphide polypeptidesdware jodalele asatat jyat membrain-distal etch. aii. 1 aanee lahan membrain-proximal etch. aii. 2 yancha samavesh aahe. ksh-kiran chrystallography aanee spectroscopy vapar heey olakhanyasathi keela gela qee prathinanchya bahutansh rachana α-helical prathinanni banalelya aahet. samdharmi coor sanrachanevyatirikt, haemaglutininsmadhye chaar upkshetra asatatah zilli-durastha receptor binding aar subdoman, vestigial domain eae, jeey receptor-distraying esteres mhanoon karya karate, fusion domain eff aanee zilli anker subdoman emm. padada anker upkshetra heey haemaglutininala ectodomenshi ectodomenshi lavchik prathinanchya sakhalya tayar karate.

