richard pastel

richard jee. pastel heey eka austreliyan american oncologist aanee endocrinologist aahet, jeey translational medical recerche pratishthit pradhyapak aahet aanee baruk ess. madheel pensylvania karkarog aanee punarutpadak aushadh sanshodhan kendrache adhyaksh aahet. bloomberg sanstha. teey yapurvi thomas jefferson vidyapithache karyakari upadhyaksh aanee thomas jefferson vidyapithachya sidney kimmel karkarog kendrache sanchalak hote. vaidyakeey aanee vaidyakeey shikshanatil vishisht sevesathi 2019 chya kweenchya vadhadivsachya sanmanarth pastel yanchi aurder auph austreliyache adhikari mhanoon niyukti karnyat aalee.
shikshan aanee prarambhik karkird.
paschim austreliyatil parth yetheel mool rahivasi asalelya pestelane khraist church vyakaran shalet shikshan ghetale. tyanni western austreliya school auph medicine vidyapithat shikshan ghetale aanee emm.buub.buub.ess. tyanni antargat aushadh, oncology aanee endocrinologymadhye vaidyakeey prashikshan ghetale. 1989 madhye tyanna royal austreliyan college auph physician (eff. aar. see. pii.) chey sadasya mhanoon sanmanit karnyat aale. tyanna ph.dii. 1991 madhye aanee emm.dii. 1997 madhye melburn vidyapithatun. tyanna niil hamilton fairley fellowship aanee royal austreliyan college auph physicianchi winthrop fellowship yaa donhi puraskaranni sanmanit karnyat aale hote. teey massatusates general hospitalmadhye vaidyakeey vishayat postdoctoral clinical aanee research phelo aanee 1991 madhye harvard medical skoolmadhye vaidyakeey vishayat postdoctoral research phelo banale.
karkird.
pastel yanchi shikago, eleanois yetheel vayavya vidyapithachya feinberg school auph medicinemadhye aanvik aushadh vibhagat sahayyak pradhyapak mhanoon bharati karnyat aalee hotee. teey newyorkmadheel albert einstein college auph medicinemadhye aushadh aanee vikasatmak aanee aanvik jivashastra vibhagat sahyogi pradhyapak aanee pradhyapak jhaale. albert einstein karkarog kendramadhye antahsravi-aashrit arbud jivashastrachya vibhagache adhyaksh mhanoon pastel yanni kaam kele.
2002 madhye, pastel yanna lombardy karkarog kendra, francis ell. chey sanchalak mhanoon niyukt karnyat aale. aanee charlote gragnani yanni georgetown vidyapith vaidyakeey kendratil karkarogshastra vibhagache adhyaksh aanee adhyakshapad pradan kele. yaa karyakalat tyanni georgetown university school auph medicinemadhye georgetown university medical centerche sahyogi upadhyaksh mhanoonahi kaam kele. pestelane rashtriy karkarog sanstheche naav nutanikaran karnyachya prayatnanche netrutva kele aanee evon foundationchya andrea jungs rajdhani stun dekhbhal kendrachi sthapana kelee. 2003 madhye, karkarog upchar aanee sanshodhanasathichya aantarrashtriy jaalyachya americi shakheche adhyaksh mhanoonahi tyanchi niyukti karnyat aalee.
2005 teey 2015 paryant, pastel heey philadelphiya, pensylvania yetheel sidney kimmel karkarog kendrache sanchalak aanee thomas jefferson vidyapithache karyakari upadhyaksh hote. teey delaware valley institute phaur clinical andd translational scienceche sansthapak sanchalak hote. 2009 madhye amerikechya sinetsathichya viniyog samitisamor saksh denyasathi tyanna bolavanyat aale hote.
2017 pasoon pastel yanni pensylvania karkarog kendra aanee punarutpadak aushadh kendrache adhyaksh aanee blumberg pratishthit pradhyapak, anuvadatmak vaidyakeey sanshodhan, barukchya blumberg institute mhanoon kaam kele aahe. janewari 2019 madhye, pastel yanna cytodine, ink. chya mandalache upadhyaksh mhanoon niyukt karnyat aale.november 2018 madhye prostagin hii tyanchi purvichi company vikat ghetalelya companyne, mukhya vaidyakeey adhikari mhanoon, meey 2019 madhye see. see. aar. 5 inhibitor (leronalimab) aanee eff. dii. aii. phasta track padnam vaparnyasathi companychya karkarogachya vaidyakeey chachanichi sthapana kelee. julai 2019 madhye teey cytodinemadhun baher padale aanee sadhya teey vistar institute karkarog kendra philadelphiya aanee blumberg pratishthit pradhyapakanche sadasya aahet.
sanshodhan.
pastelchya karyat 88023 peksha jaast sandarbh aahet aanee 152, 152 nirdeshank 476 chaa etch-nirdeshank aahe. gugal scholarne tyachya sanshodhanachya kshetransathi tyala sthan dile aaheh peshi chakr (#1), prostate karkarog, oncology aanee stanacha karkarog.
pastelchya sanshodhanat karkarogachi suruvat aanee stanacha aanee prostate karkarogasah pragati samajoon ghenyachya yogdanancha samavesh aahe. pestelane dakhavun dile qee nuclear receptors (istrogen, androgen aanee pii. pii. aar. jee. emm.) acetylated aahet aanee hii ghatana samprerak sanket aanee vaadh niyantranat darr-maryadit aahe-asha prakare karkarog upcharansathi eka naveen lakshya olakhate. tyachya prayogshalene dakhavun dile qee hii vividh jaivik prakriyanvar parinam parinam anugrahakanmadhye sanrakshit keleli eka samanya yantrana hotee.
peshichakra kshetrat, pastelchya sanshodhanat assa shodh disun aala aahe qee cyclins heey oncogenic aanee tumour suppressor sanketanche thet pratilekhan lakshya aahet. tyanni dakhavun dile qee cycline abhivyakti hii oncogene-prerit stanachya arbudachya vadhisathi darr-maryadit aahe. tyachya sanshodhanane prarambhik vaidyakeey sanshodhan karyakramansathi (palbosicilib, aine. see. tii. 02947685) eff. dii. aii. laa kelelya ind (tapasatmak naveen aushadh) anuprayogamadhye purv chikitsalayin sandarbh sandarbh mhanoon kaam kele, jeey aata stanachya karkarogachya upasanchanchya upcharansathi kaljiche manak aahe. teey cyclinschya naun-canonical karyanche pranete rahile aahet aanee cyclins mirna biogenesis, cellular migration, mitochondrial metabolism (warberg effect), angiogenesis aanee nuclear receptor function aanee harmon signalling "inn vivo" yasah vividh karyanche niyaman karatat heey darshavinare teey pahile hote.
pestelane vivomadhye stanachya karkarogachya moolpeshichya vistarasathi aavashyak asalelya pramukh lakshya janukanchi vyakhya kelee aahe, jyat jyat, see-juuna, canonical nf-kebby marg, peshi bhavitavya nirdharan marg prathine prathine aanee see. see. aar. 5 yancha samavesh aahe.
pestelane shodhale qee see. see. aar. 5 heey stun aanee prostate karkarog yaa donhimadhil karkarog metastasis niyantrit karate, jeey yaa kshetrat jaaree kelelya patents upcharatmak lakshyachi kshamata pradan karate. pestelane yaa patentscha samavesh tyanni sthapan kelelya (prostagin) jaivtantradnyan companyt keela, jee nantar cytodine vikat ghetali. pestelane tyanantar meey 2019 madhye see. see. aar. 5 laa jalad gatine padnam midvanyachya uddeshane companyche sadhyache sakriy karkarog upchar chikitsalayin chachani upkram suru kele.
pastel heey chaar jaivtantradnyan companyanche sansthapak aahet aanee karkarogache nidan, upchar aanee tantradnyan yaa kshetranmadhye tyanche paytant aahet.
vaiyaktik jeevan.
pastelche lagn annah pastelshee jhaale aahe aanee tyanna teen mule aahet. too scullin sarkarchya sanrakshn mantri albert green yancha panjoba aahe.
1984 madhye pestelane vaa steet running (5,000 meater track, 10,000 meater road) aanee walking championship (5,000 meater, meater aanee aanee jinkley.

