pyrimethamine

itaranmadhye darapreem yaa brand navane vikale jaanare pyrimethamine heey eka aushadh aahe jeey leukovorins (leukovorincha vapar pyrimethamine dushparinam qamee karnyasathi keela jaato; tyat aantarik parajivivirodhi kriyakalap nasato) toxoplasmosis aanee systoesosporiasis yaa parjivi roganvar upchar karnyasathi vaparale jaate. etch. aay. vhee./eds asalelya lokanmadhye pneumosistis gerovacy pneumonia talhanyasathi talhanyasathi paryay mhanoon dapsones dekhil yacha vapar keela jaato. yacha vapar purvi maleriyasathi keela jaat hota parantu pratikarshaktimule aata tyachi shifaras kelee jaat nahee. pyrimethamine tondane ghetale jaate.
samanya dushparinamadhye jatharantra vikar, gambhir allergic pratikriya aanee asthimajja dadapane yancha samavesh hoto. folletchi kamatarata asalelya lokanni yacha vapar karoo naye jyamule raktakshay jhaala aahe. yamule karkarogacha dhoka vadhu shakato ashee chinta aahe. kadhikadhi garbhadharanedarmyan vaparale jaat asatana pyrimethamine balasathi surakshit aahe qee nahee heey spasht nahee. pyrimethamine follick acid virodhi mhanoon vargikaran kele jaate. heey follick acid chayapachay rokhoon aanee tyamule dii. aine. aii. tayar karoon karya karate.
pyrimethamine 1952 madhye sapadale aanee 1953 madhye vaidyakeey vaparat aale. teey jaagtik aarogya sansthechya aavashyak aushadhanchya yadeet aahe. februwari 2020 madhye americet yala samanya mhanoon manyata denyat aalee.
vaidyakeey vapar.
pyrimethamine samanyatah sulphonamide aanee folynic acids dile jaate.
yacha vapar toxoplasmosis, actinomycosis aanee isosporisischya upcharansathi aanee pneumosistis gerovacy pneumoniachya upchar aanee pratibandhasathi keela jaato.
toxoplasmosis.
sakriy toxoplasmosisver upchar karnyasathi sulfadiazinchya sanyogane pyrimethamine dekhil vaparale jaate. hii done aushadhe anukrame trimethoprim aanee sulphamethoxazole-dihydropholate reductase aanee dihydropteroate synthes yaa aushadhansarakhich utsechak uddishte bandhatat.
retinocoroiditisvar upchar karnyasathi pyrimethaminecha vapar anek chachanyanmadhye dekhil keela gela aahe.
garbhadharanecha vichar.
pyrimethaminela americet garbhadharanechi shreni see mhanoon label kele jaate. aajparyant, garbhadharanetil tyachya jokhmimbaddal kinwa garbhavar suru tyachya parinamambaddal purese purave upalabdh naheet.
maleria.
heey pramukhyane 'plasmodium falsiperum' viruddha sakriy aahe, parantu 'plasmodium vivax' viruddha dekhil sakriy aahe. pyrimethamine-pratirodhak prabhedanchya udayamule "pii. falciparum, "ekte pyrimethamine aata kvachitach vaparale jaate. sulfadiazinsarkhya dirghkal karyarat asalelya sulphonamidechya sanyogane, jaree yaa sanyojanacha pratikar vadhat asala taree, fansdidarsarkhya mothya pramanavar tyacha vapar keela jaat asey.
matbhed.
follet-kamatarata asalela raktakshay asalelya lokanmadhye pyrimethamine praman pratibandhit aahe.
dushparinam.
jevha jaast matra vaparlya jaatat, toxoplasmosischya upcharanpramane, pyrimethaminemule malmal, ulatya, glocytis, bhook naan lagane aanee atisar yasarkhi jatharantravishayak lakshane udbhavu shakatat. pural, jeey atisanvedanshil pratikriyeche soochak asoo shakate, teey dekhil visheshtah sulphonamideschya sanyogane disun yete. madhyavarti majjasansthevar suru parinamanmadhye ataxia, kampane aanee daure yancha samavesh hoto. thrombocytopenia, leukopania aanee raktakshay yasarkhe hematologic dushparinam dekhil houu shakatat.
parasparsanvad.
methotrexet aanee trimethoprim yasarkhe itar antifolate ghatak pyrimethaminechya antifolate krutinna balkat karoo shakatat, jyamule folletchi kamatarata, raktakshay aanee itar rakt apchayi houu shakatat.
krutichi yantrana.
dihydropholate reductase yaa enzymela spardhatmakaritya rokhoon pyrimethamine dihydropholatemadhun tetrahydropholic aesidchya punarjananat hastakshep karate. protojoas anek prajatinmadhye dii. aine. aii. aanee aar. aine. aii. sanshleshanasathi tetrahydropholic aaml aavashyak aahe. amyotrophic lateral sclerosismadhye samavisht asalelya saud 1 yaa pramukh prathinanchi abhivyakti qamee karnyasathi dekhil heey aadhalun aale aahe.
itar aushadhe.
pyrimethamine samanyatah folynic aaml aanee sulfadiazines dile jaate.
pratikar yantrana.
pyrimethaminecha pratikar vyapak aahe. dihydropholate reductasesathi maleria janukatil utparivartan tyachi parinamkarakta qamee karoo shakate. hii utparivartane hydrogen bandh aanee steric parasparsanvad gamavalyamule pyrimethamine aanee dihydropholate reductage yanchyatil bandhan sambandh qamee karatat.
itihas.
nobel paritoshik vijete american shastradnya gertrude elean yanni maleriyavar maat karnyasathi baroj-velakam (aata glaxosmithcline bhag) yethe aushadh vikasit kele. pyrimethamine 1953 pasoon upalabdh aahe. 2010 madhye, glaxosmithcline daraprimche vipanan haqq corformala vikale. impax prayogshalanni 2014 madhye corforma kharedi karnyacha prayatna keela aanee march 2015 madhye darapreems adhigrahan purn kele. august 2015 madhye, adhikar turing pharmaceuticalsdware kharedi karnyat aale. turing nantar yuu. ess. madhye aushadhachya eka matrechi kimmat vadhavalyamule kimmatinchya vadhichya vadasathi kukhyat jhaale.ess. aamchyakadun $13.50 teey $750, mhanje 5,500% vaadh.
samaj aanee sanskruti.
arthshastra.
2015 madhye americet, turing pharmaceuticalsvar 50 putt vaadh kelyabaddal teeka karnyat aalee, us $13.50 varoon $750 prati tablet, jyamule eka rugnalayat nondavalelya upcharansathi $75,000 kharch jhaala.
united states.
americet, 2015 madhye, turing pharmaceuticalschya darapreem tabletsathi yuu. ess. vipanan adhikaranchya adhigrahanantar, darapreem hii eka-srot aanee vishesh aushadhanirman vastoo bunley aanee kimmat vadhavanyat aalee. 75 mii. gra. matra ghetalelya vyaktisathi masik abhyaskramacha kharch eka rugnalayat sumare $75,000/mahina kinwa prati tablet $750 paryant vadhala, tarr purvi tyachi kimmat $13.50 hotee.
bahyarugna aata samudayik aushadhalayatun aushadhe midvu shakat navhate, parantu keval ekach vitaran aushadhalayadvare, walgreens vishesh aushadhalay aanee sanstha yapudhe tyanchya samanya ghauk vikretyakadun magani karoo shakat navhate, parantu darapreem thet karyakramasah khaate ughadave lagale. turingche mukhya karyakari adhikari martin shkreli yanchya netrutvakhalil retrophene yaa companychya sadarikaranat, jyatoon turingne daraprimche adhikar midavale, asey suchavale qee bund vitaran pranalimule generic spardhakanna generic aushadhachya eff. dii. aii. manjurisathi aavashyak asalelya jaivasamatva abhyasasathi aushadhe kayadeshiraritya midvanyapasun rokhata yeu shakate.
shkreleene kimmatitil vadhicha bachav kartana mhatale, "jarr ekhadi company cyclechya kimmatila aashcharyakarak martin vikat hotee aanee aamhi tee company vikat gheto aanee aamhi toyotachya kimmati aakarnyas sangato, tarr mallah vatat nahee qee too gunha asava."yaa pratisadacha parinam mhanoon, shkreleene tyachya nidhichya halchaliche spashtikaran denyasathi madat karnyasathi eka sankatgrast jansampark sansthela niyukt kele. turing pharmaceuticalsne 24 november 2015 roji jaheer kele qee, "teey shevati tyaa aushadhachya yadee kimmatit kapat karnar naheet", parantu teey rugna sahayya karyakram deu kartil. "newyork times" chey patrakar andreau pollack yanni namood kele qee heey karyakram "atyant mahagadya kimatichi aushadhe aushadhe companyansathi manak aahet. teey rugnanna aushadh midvanyas saksham karatat aanee bahutansh kharch vima kampanya aanee kardatyanvar dhakaltat."
etch. aay. vhee. medicine associates aanee compaxive disease society auph america yasarkhya chikitsak gatanni kimmatinchya vadhivar teeka kelee.
2016 madhye, sidney vidyapithachya pathbalane sidney vyakaranatil hyschoolchya vidyarthyanchya eka gatane sanshleshan tulanene sope aanee kimmat-vaadh anyaykarak aahe yache udaharan mhanoon pyrimethamine tayar kele. tyachya chamoone aamchyasathi $20 sathee 3.7 gramm utpadan kele, jyachi kimmat tyaveli americet $35,000 aanee $110,000 darmyan hotee. shkreleene sangitale qee shalkari mule spardha kareet navhati, bahudha kaaran aavashyak jaivasamatva abhyasasathi companyne thet puravalelya vidyaman aushadhacha namuna aavashyak asato aanee keval aushadhalayatun kharedi keela jaat nahee, joou turing deu karnyas nakar deu shakato. tathapi, vidyarthyanche karya 'daad guardian' aanee 'time' masikat aanee aii. bii. see. austreliya, bii. bii. see. aanee see. aine. aine. varr prakashit karnyat aale hote.
22 aktoobar 2015 roji, impremis pharmaceuticalsne jaheer kele qee tyanni americet 100-mojanichya batalisathi $99 pasoon tondawate ghetalya ghetalya capsulemadhye pyrimethamine aanee leukovorinchi sanyugmit aanee sanukoolit formulation upalabdh karoon dilee aahe. februwari 2020 madhye americet pyrimethaminela generic mhanoon manyata denyat aalee.
janewari 2020 madhye, eff. tii. see. neey vyerachya virodhat "darapreem yaa jivanrakshak aushadhachi maktedari rakhanyasathi vistrut spardhatmak virodhi yojanecha aarop karat" khatala dakhal keela. december 2021 madhye eka todga nighala. aii. pii. batmyannusar, yaa tadjodisathi 'vira aanee phenixus yanni tyanchya krutimule kathitpane trast jhalelya grahakanna 10 varshant 4 kotee dollarsparyantcha dilasa dene aavashyak aahe aanee tyanna konatyahi sambhavya generic pratispardhyala darapreem upalabdh karoon dene aavashyak aahe."kayada 360 nusar, companyche karyakari kevin mullidi" bahutek aushadhanirman companyanmadhye 8 takkyanpeksha jaast vaataa asalelya kinwa kaam kaam kampanyanvar saat varshanchya bandee ghalanyas sahmat jhaale."
itar desh.
bharatat, dazanbharahun adhik utpadak pyrimethamine golya vikatat aanee generic pyrimethamine anek sanyojan us $0.40 teey us $0.10 (3-7 rupaye) yaa kimmatit upalabdh aahet.
yuu. keey. madhye, tech aushadh jee. ess. keey. kadoon 30 golyansathi (pratyeki sumare $0.66) 20 dollar (£13) kimmatit upalabdh aahe.
austreliyamadhye, bahutek aushadhavikretyanmadhye 50 golyansathi (pratyeki sumare 0.18 dollars) 9.35 americi dollar (eka $12.99) kimmatit heey aushadh upalabdh aahe.
brazilmadhye heey aushadh prati golee 0.7 dollar kinwa sumare 0.02 dollarla upalabdh aahe.
canadamadhye, 2013 madhye heey aushadh bund karnyat aale hote, parantu jevha garaj bhasel tevha rugnalaye heey aushadh swatah tayar karoo shakatat. jee. ess. keey. yuu. keey. madhoon thet canadamadhye aayat kelele darapreem heey eka online pharmasimadhun prati tablet 2.20 dollarmadhe upalabdh aahe.
switzerlandmadhye, 30 golyansathi (sumare $0.32 prati tukada) heey aushadh 9.45 dollarmadhe (chf9.05) upalabdh aahe.
sanshodhan.
2011 madhye, sanshodhakanna asey aadhalale qee pyrimethamine beeta-hexosaminidase kriyakalap vadhavu shakate, asha prakare usheera suru suru teey-sacks rogachi pragati sambhavyaritya mandavate. amyotrophic lateral sclerosisvar upchar mhanoon clinical chachanyanmadhye tyache moolyankan kele jaat aahe.

