
dehydroapiendrosterone

dehydroapiendrosterone (dii. etch. aii.), jyala androstenaolone asehi mhanatat, haah eka antarjaniy steroid samprerak purvavarti aahe. manavanmadhye sarvadhik pramanat pasarana steroidspacky heey eka aahe. mutramargatil granthi, gonads aanee mendumadhye dii. etch. aii. tayar hote. heey gonads aanee itar vividh uutinmadhye androgen aanee istrogen seeks steroidschya jaivasanshleshanat chayapachay madhyavarti mhanoon karya karate. tathapi, dayamadhye tyachya swatachya adhikarat vividh sambhavya jaivik parinam dekhil aahet, jeey anoo aanee peshi prushthbhagachya receptorschya shrenishi bandhale jaatat aanee neurosteroid aanee neurotrophic factor receptorsche modulator mhanoon karya karatat.
americet, dii. aii. aii. heey pratyaksh purak mhanoon aanee prasteron navache aushadh mhanoon vikale jaate.
jaivik karya.
androgen mhanoon.
dii. aii. aii. aanee androstenadione sarkhya itar adhivrukkatil androgen, jaree tulanene kamkuvat androgen asale taree, edrenarchchya androgenic prabhavansathi jababdar aahet, jase qee lavkar guptang aanee aksheey kesanchi vaadh, praudh-prakarchya shariracha gandh, cases aanee tvacheche telkatpana vadhane aanee saumya murum. tvacha aanee kesanchya thipkyanmadhye testosterone aanee dihydrotestosterone (dii. etch. tii.) madhye rupantar karoon dii. etch. aii. sthanik patalivar samarthyavan hote. sampoorn androgen asanvedansheelata lakshansamuchchay (see. aii. aay. ess.) asalelya jyaa striyanmadhye naun-functional androgen receptor (aii. aar.) aahe aanee jyaa dii. aay. aii. aanee itar androgenchya androgenic prabhavanpasun rogpratikarak aahet, tyaa anupasthit asatat kinwa samanyatah viral/viral pii. aay. aanee aksheey cases aanee sharirache cases asatat, jeey edrenarch aanee pabarch yaa donhi thikani sharirachya kesanchya vikasat dii. aay. aii. aanee itar androgenchi bhoomika darshavtat.
istrogen mhanoon.
dii. etch. aii. heey eka kamkuvat istrogen aahe. yavyatirikt, heey yonisarkhya vishisht uutinmadhye estradiolsarkhya shaktishali istrogenmadhye rupantarit hote aanee tyadvare asha uutinmadhye istrogenic prabhav nirman hoto.
neurosteroid mhanoon.
neurosteroid aanee neurotrophene mhanoon, madhyavarti majjasansthevar dayaeche mahattvache parinam hotat.
jaivik kriyakalap.
samprerak kriyakalap.
androgen receptor.
jaree teey testosterone aanee dii. etch. tii. sarkhya adhik shaktishali androgensathi antarjanik purvavarti mhanoon karya karat asale, taree dayamadhye kahee pramanat androgenic kriyakalap asalyache aadhalun aale aahe, jeey qamee aakarshan (qee = 1 microne), androgen receptorche (aii. aar.) kamkuvat aanshik agonist mhanoon karya karate. tathapi, receptormadhye tyachi aantarik kriya khoopach kamkuvat asate aanee tyamule, testosteronsarkhya purn agonistshee bandhanyasathichya spardhemule, tee pratyakshat testosterone aanee dihydrotestosterone (dii. etch. tii.) patalichya parisancharananusar aanee mhanoon antiandrogensarkhi adhik virodhisarkhi vagoo shakate. tathapi, receptorshee tyache naate khoop qamee aahe aanee tyaa karanastav, samanya paristhitit jaast mahatva asanyachi shakyata nahee.
istrogen receptors.
androgen receptorshee asalelya tyachya sambandhavyatirikt, dii. etch. aii. anukrame 1.1 microne aanee 0.5 micronechya qee moolyansah, aanee anukrame 1 microne aanee 200 micronechya eae. see. 50 moolyansah, erae aanee erbita istrogen receptors bandhale (aanee sakriy) asalyache dekhil aadhalun aale aahe. jaree too 30-70% chya kamal karyakshamatesah eraecha aanshik agonist asalyache aadhalun aale asale, taree sakriyatechya yaa patalisathi aavashyak asalelya sandratemule yaa receptorvar dii. eae. aii. chee kriya sharirikdrushtya arthpurn asanyachi shakyata qamee aahe. tathapi, ullekhaniyapane, dii. etch. aii. aii. astradiolchya samaan kinwa pratyakshat tyapeksha kinchit jaast kamal pratisadasah erbitache purn agonist mhanoon karya karate aanee manvi shariratil parisancharanatil aanee sthanik uutinmadhil tyachi patali receptorla tyach pramanat sakriy karnyasathi pureshi jaast asate jee tyanchya kamal, naun-ovulatory sandratepeksha kahee pramanat jaast pramanat firana astradiolchya patalisah disate; kharokhar, jevha astradiols tyanchya sharirik sandratechya samatulya patalivar donhi patalyansah jodale jaate, tevha erbitachi ekoon sakriyata duppat hote.
itar anugrahak.
dii. etch. aii. progesterone, glucocorticoid kinwa mineralocorticoid receptors bandhat nahee kinwa sakriy karat nahee. androgen aanee istrogen receptors vyatirikt dii. etch. aii. chya itar nuclear receptor lakshyanmadhye pii. pii. aar. aii., pii. ex. aar. aanee qaar yancha samavesh hoto. tathapi, jaree dii. aii. aii. haah kruntakanmadhil pii. pii. aar. aii. aanee pii. ex. aar. chaa legand asala, taree too manavanmadhye nasato. thet parasparsanvadavyatirikt, diaya apratyaksh, janukeey yantranedvare itar mojki prathinanche niyaman karate asey manale jaate, jyat sayyap2see11 aanee 11beeta-hsd1 yaa enzymescha samavesh aahe-jyapaiki nantarche cortisolsarkhya glucocorticoidschya jaivasanshleshanasathi aavashyak aahe aanee diechya antiglucocorticoid prabhavanmadhye-aanee vahak prathine igfbp1 madhye sahbhagi asalyache suchavale gele aahe.
neurosteroid kriyakalap.
neurotransmitter receptors.
dii. etch. aii. anek neurotransmitter receptorsver thet karya karate asey aadhalun aale aahe, jyat aine. emm. dii. aii. receptorche positive allosteric modulator mhanoon, gaba receptorche negative allosteric modulator mhanoon aanee σ1 receptorche agonist mhanoon kaam karane samavisht aahe.
neurotrophene receptors.
2011 madhye, aashcharyakarak shodh lagla qee dii. etch. aii., tasech tyache sulfate ester, dii. etch. aii.-ess., thet trca aanee pii75aine. tii. aar., cheta vadhicha ghatak (ngf) aanee mendu-vyutpann neurotrophic ghatak (bii. dii. aine. eff.) sarkhya neurotrophene receptors uchch aakarshanasah bandhatat aanee sakriy karatat. tyanantar dii. etch. aii. heey uchch aakarshanasah tii. aar. keey. bii. aanee tii. aar. keey. see. shhee bandhale gelyache aadhalun aale, jaree teey fakt tii. aar. keey. see. sakriy karat hote, tii. aar. keey. bii. nahee. dii. etch. aii. aanee dii. etch. yaa receptors qamee nanomolar shreneet (sumare 5 nm) sambandh asalelya bandhanat bandhalele aahet, jeey tarihi ngf (0.01-0.1 nm) sarkhya atyant shaktishali polypeptide neurotrophene tulanet pariman qamee asalelya andaje done kramanche hote. konatyahi paristhitit, heey receptors sakriy karnyasathi aavashyak sandratevar dye aanee dye-ess donhi prasarit hotat aanee asha prakare tyanna mahattvache antarjanit neurotrophic ghatak mhanoon olakhale jaate. tyanchya polypeptide neurotrophene samkakshanchya tulanet tyanchya lahan-renu aanee steroidal swarupamule tyanna tevhapasoon "steroidal microneurotrophene" asey label denyat aale aahe. tyanantarchya sanshodhanat asey suchavale gele aahe qee, dii. etch. aii. aanee/kinwa dii. etch. aii.-ess. heey majjasansthechya utkrantichya suruvatipasunach neurotrophene receptorsche phylogenetically pracheen "purvajanche" legands asoo shakatat. dii. aii. aii. heey neurotrophene receptors bandhate aanee prabhavipane sakriy karate heey nishkarsh, prasarit honanya dii. aii. aii. chya patalitil ghat aanee vay aanee vay-sambandhit neurodegenerative rog yanchyatil sakaratmak sambandh spasht karoo shakatat.
microtubulashy sambandhit prathine 2.
tyachpramane pregnanolon, tyache krutrim vyutpann 3β-methoxypregnonolone (nakasha-4343) aanee progesterone, diaya heey sukshmanalika-sambandhit prathine 2 (nakasha 2), visheshtah nakasha 2c upprakarashi (kd = 27 microne) bandhalele aadhalale aahe. tathapi, pregninolonsarkhya tubulinshy nakasha 2 chey bandhan diane vadhavale aahe qee nahee heey spasht nahee.
aii. dii. etch. dii.
kahee sanshodhanat asey disun aale aahe qee aii. dii. etch. dii. asalelya lokanmadhye dii. etch. aii. chee patali khoop qamee asate aanee methylphenidate kinwa bupropian (uttejak prakarchi aushadhe) vaparoon upchar kelyane dii. etch. aii. chee patali samanya hote. 
itar upkram.
jee6pdh avarodhak.
dii. etch. aii. haah (qee = 17 microne; aay. see. 50 = 18.7 microne) chaa eka spardhatmak avarodhak aahe aanee too patali qamee karnyas aanee naduff-aadharit mukt muldravyanche utpadan qamee karnyas saksham aahe. asey manale jaate qee hii kriya bahudha dahak, antihyperplastic, chemopreventive, antihyperlipidemic, madhumehavirodhi aanee antiobasic, tasech diechya kahee rogpratikarak kriyansathi jababdar asoo shakate (yaa kalpanela samarthan denyasathi kahee prayogik puravyansah). tathapi, asehi mhatale gele aahe qee daydware 'inn vivo' dware jee6pdh kriyakalap rokhane disun aale nahee aanee diala jee6pdh 'inn vitro' pratibandhit karnyasathi aavashyak asaleli sandrata khoop jaast aahe, tyamule diechya anishchit prabhavanmadhye jee6pdh pratibandh sambhavya yogdan dete.
karkarog.
karkarog pratibandhatmak gunadharmancha dawa kelyabaddal, dii. etch. aii. purak aushadhanna chemopreventive mhanoon protsahan denyat aale aahe. yaa davyanna samarthan denare vaidnyanik purave aahet.
vividh.
dii. etch. aii. heey tii. aar. pii. vhee. 1 laa spardhatmakaritya pratibandhit karate asey aadhalun aale aahe.
jaiv rasayanshastra.
jaivasanshleshan.
adrenocorticotropic samprerak (acth) chya niyantranakhali adhivrukk aachchadanchya jona reticularismadhye aanee gonadotropin-mukt karnara samprerak (gnrh) chya niyantranakhali gonadsdware dii. etch. aii. tayar hote. heey mendumadhyehi tayar hote. collesterolchya bajuchya sakhalitil vichhedan enzyme (sayyap11aii1; pii450scc) aanee 17α-hydroxylase/17,20-lies (sayyap17aii1) yaa enzymesdware collesterolmadhun diache sanshleshan kele jaate, jyamadhye pregnanolon aanee 17α-hydroxypregnolone heey madhyavarti ghatak asatat. heey mukhytah adhivrukk aachchhadanatun tayar hote, jyamadhye keval 10 takke gonadsmadhun stravale jaate. paridhiy uutinmadhil dii. etch. aii.-ess. chya nirjalikaranamule sumare 50 teey 70 takke parisanchari dii. etch. aii. tayar hote. dye-ess swatach jawaljawal keval adhivrukk aachchhadanatun udbhavate, jyamadhye 95 teey 100% mahilanmadhye adhivrukk aachchhadanatun stravale jaate.
antarjan utpadan vadhavane.
niyamit vyayamamule shariratil dii. aay. aii. chey utpadan vadhate. ushmank nirbandhamule narvanar pranyanmadhye dayamadhye vaadh jhalyachehi disun aale aahe. kahijan asey manatat qee ushmank nirbandhamule jhaleli antarjaniy dayamadhil vaadh hii ushmank nirbandhanshi sambandhit asalelya dirgh aayurmanachya apekshesathi anshatah jababdar aahe.
vitaran.
raktasanchalanamadhye, dii. aii. aii. pramukhyane albuminshi bandhale jaate, jyamadhye thode praman laingik samprerak-bandhankari globulinshi (ess. etch. bii. jee.) bandhale jaate. albumin kinwa ess. etch. bii. jee. shhee sambandhit nasaleli chhotishi urvarit dii. etch. aii. hii akhandit aanee prasarat mukt asate.
dii. aii. aii. neey rakt-menducha adthala sahajpane madhyavarti majjasansthet paar keela.
chayapachay.
sulfotransferase enzymes sult2aii1 dware see3β sthiteet sulfessiondware dayaeche diae-ess madhye rupantar hote aanee kahee pramanat sult1eae1. heey naisargikaritya adhivrukk aachchhadanamadhye aanee yakrut aanee aatadyanmadhil first-paas chayapachayadarmyan hote jevha bahya diae tondawate dile jaate. paribhramanat asalelya dii. etch. aii.-ess. chee patali dii. etch. aii. chya patalipeksha andaje 250 teey 300 putt jaast asate. steroid sulphatage (ess. tii. ess.) dware paridhiy uutinmadhye dii. etch. aii.-ess. chey punha dii. etch. aii. madhye rupantar kele jaau shakate.
dii. aii. aii. chey antim ardhayushya keval 15 teey 30 minitanche asate. yaulat, dii. etch. aii.-ess. chey antim ardhayushya 7 teey 10 taas itake jaast asate. dii. aii.-ess. chey punha dii. aii. eae. madhye rupantar kele jaau shakate, tyamule teey dii. aii. eae. sathee parisanchari jalashay mhanoon kaam karate, jyamule dii. eae. aii. chaa kalavadhi vadhato.
diechya chayapchayamadhye dye-ess, 7aii-hydroxy-dye, 7bii-hydroxy-dye, 7-keto-dye, 7aii-hydroxypiendros aanee 7bii-hydroxypiendros, tasech androstenadiol aanee androstenadione yancha samavesh hoto.
garbhadharana.
garbhadharanedarmyan, dii. etch. aii.-ess. chey chayapachay garbhatil yakrutatil 16α-hydroxy-diiya aanee 15α-hydroxy-diiya yaa sulfetsmadhye anukrame astriol aanee estrol yaa istrogenchya utpadanat madhyavarti mhanoon kele jaate.
star.
manavanmadhye tarunya yenyapurvi, adhivrukk aachchadanchya zona reticularischya farkane dii. etch. aii. aanee dii. etch. aii.-ess. chee patali vadhate. vayachya 20vya varshi dii. etch. aii. aanee dii. etch. aii. chee sarvoch patali disun yete, jyanantar ayushyabhar vay-avalambun asaleli ghat, akheris prepuberal sandratekade parat jaate. praudh purushanmadhye diechya plasmachi patali 10 teey 25 nm asate, rajonivruttipurv mahilanmadhye 5 teey 30 nm asate aanee rajonivruttinantarchya mahilanmadhye 2 teey 20 nm asate. yaulat, dii. aay. aii.-ess. patali hii <aay. dii. 1> micronometervar jaast tivratecha kram aahe. 60 teey 80 varshe vayogatatil purush aanee striyanmadhye dii. etch. aii. aanee dii. etch. aii. chee patali qamee houn nanomolar aanee micromolar shreniparyant khalee jaate.
dii. aii. aii. chee patali khalilpramane aaheh
mapan.
jawaljawal serve dii. aii. aii. heey adhivrukk granthitoon tayar kele jaat asalyane, dii. aii. aii./dii. aii. aii. chey rakt mojmap heey adhivrukk karkarog kinwa hyperplasiamadhye disalyapramane adhivrukkatil atirikt kriyakalap shodhanyasathi upayukt aahet, jyat janmajat adhivrukk hyperplasiachya kahee prakarancha samavesh aahe. polycystic overy syndrome asalelya mahilanmadhye dii. etch. aii.-ess. chee patali vadhanyacha cull asato.
rasayanshastra.
dii. aii. aii., jyala androst-5-aine-3β-oel-17-vann asehi mhanatat, heey naisargikaritya aadhalanare androstein steroid aanee 17-catosteroid aahe. yacha sanrachanatmakdrushtya androsteniol (androst-5-aine-3β, 17β-diol), androstenion (androst-4-aine-3,17-dione) aanee testosterone (androst-4-aine-17β-oel-3-vann) yanchyashi jawalcha sambandh aahe. dii. etch. aii. heey epiandrosteronche (5α-androstan-3β-ol-17-eka) 5-dehydro analogue aahe aanee tyala 5-dehydroapiendrosterone kinwa δ5-epiandrosterone mhanoon dekhil olakhale jaate.
isomers.
dehydroapiendrosterone" haah shabd rasayanikdrushtya sandigdha aahe kaaran tyat epiendrosteronmadhil vishisht sthanancha samavesh nasato jyavar hydrogen anoo gahal asatat. dii. aii. aii. heey swatah 5,6-didridripiendros kinwa 5-didridridernaidroters aahe. naisargikaritya aadhalanare anek isomers dekhil astitvat aahet aanee tyanchya samaan kriya asoo shakatat. 1-dehydroapiendrosterone (1-androsterone) aanee 4-dehydroapiendrosterone heey dayaeche kahee isomers aahet. heey isomers tantrikdrushtya 'dia' dekhil aahet, kaaran teey dehydroapiendrosteronsterste aahet jyamadhye epiendrosterone sangadyatun hydrogen kadhale jaatat.
dehydroandrosterone (dii. etch. aii.) haah daicha 3α-epimer aahe aanee eka antarjaniy androgen dekhil aahe.
itihas.
1934 madhye edolph beautenand aanee curt tserning yanni manvi laghvipasoon pratham dii. eae. aii. vegale kele.