
eae. pii. ess. pii. synthes

5-anolpyruvilshickimate-3-phosphet (eae. pii. ess. pii.) synthes heey vanaspati aanee sukshmajivandvare tayar kelele eka enzyme aahe. epseps rasayanik abhikriyeche utprerak thartatah
asha prakare, yaa enzymeche done thurr phosphoenolpyruvate (pep) aanee 3-phosphoshikimet aahet, tarr phosphet aanee 5-anolpyruvilshicimate-3-phosphet hii tyachi done utpadane aahet.
heey enzyme pranyanchya genomemadhe nasate. glyphosetsarkhya vanaushadhinashakansathi heey eka aakarshak jaivik lakshya sadar karate. yaa janukachi glyphosate-pratirodhak aavrutti anuvanshikdrushtya sudharit pikanmadhye vaparali gelee aahe.
namkaran.
heey enzyme hastantarananchya kutumbatil aahe, vishishtapane methyl gatanshivay itar eril kinwa alkyle gatanna hastantarit karnare. yaa enzyme vargache paddhatshir naav phosphoenolpyruvate aaheh 3-phosphoshikimet 5-"oo"-(1-carboxyvinyl)-transfer. samanya vaparat asalelya itar navanmadhye heey samavisht aaheh
rachana.
eae. pii. ess. pii. synthes heey sumare 46,000 chya aanvik vastumanasaha eka monomeric enzyme aahe. teey done kshetranni banalele aahe, jeey prathinanchya pattyanni jodale jaatat. haah strand kajal mhanoon kaam karato aanee done prathinanche kshetra jawal aanoo shakato. jevha eka thurr enzymeshee bandhala jaato, tevha legand bandhamule enzymeche done bhag sakriy thikani tharbhovati ghatt hotat.
glyphosate sanvedansheelatenusar eae. pii. ess. pii. synthes done gatanmadhye vibhagala gela aahe. vanaspati aanee kahee jivanunmadhye asalele varg I chey enzyme, qamee sukshmamolar glyphosate sandratemadhye pratibandhit kele jaate, tarr varg II chey enzyme, jeey itar jivanunmadhye aadhalate, teey glyphosetdware pratibandh karnyas pratirodhak aahe.
shikmimet marg.
ii. pii. ess. pii. synthes heey sukshmajantu, burshi aanee vanaspatinmadhil shikimet margadvare sugandhit amino aaml fenilalnin, tyrosine aanee tryptophanchya jaivasanshleshanat sahbhagi hote. eae. pii. ess. pii. synthes keval vanaspati aanee sukshmajivandvare tayar keela jaato; tyasathi januk coding sastan pranyanchya genomemadhe nahee. kahee pranyanchya aatadyantil vanaspatinmadhye eps asatat.
pratikriya.
epsp synthes hii pratikriya utprerit karate jee esitalsarkhya tetrahedral madhyavartidvare shikimet-3-phosphet adhik phosphoenolpyruvetche 5-anolpyruvilshicimate-3-phosphatemadhe (epsp) rupantar karate. sakriy thikanavaril moolbhut aanee amino aaml heey pepchya hydroxyl gatachya apbhranshamadhye aanee tetrahedral madhyavartishi sambandhit proton-vinimay payyanmadhye anukrame guntalele asatat.
yaa pratikriyesathichya enzyme kineticschya abhyasane prakriyechya pratyek tappyacha vishisht kram aanee urja nirdharit kelee aahe.
vanaushadhinashakanche lakshya.
ii. pii. ess. pii. synthes heey herbicide glyphosetche jaivik lakshya aahe. glyphosate haah eps synthescha spardhatmak avarodhak aahe, joou sankraman sthitee analogue mhanoon karya karato joou pepapeksha eps-ess3pii complexeshy adhik ghattapane bandhato aanee shikimet marg rokhato. yaa bandhanamule enzymeche utpreran pratibandhit hote aanee marg bund hoto. akheris, jiwala jaganyasathi aavashyak asalelya sugandhit amino aesidchya abhavamule jeev mrutyu pavto.
donhi glyphosatela pratirodhak asalelya aanee vanaspatinchi pureshi vaadh karnyasathi pureshi karyaksham asalelya enzymechi eka aavrutti monsanto shastradnyanni see. pii. 4 () navachya "agrobacterium" strainmadhye khoop chachani aanee trutinantar olakhali. glyphosate utpadan suvidhetil kachara-poshit stambhat see. pii. 4 haah taana jiwant aadhalala. see. pii. 4. eae. pii. ess. pii. synthes enzyme anek anuvanshikdrushtya sudharit pikanmadhye tayar kele gele aahe.