rasta

peshi jivashastra kshetrat, tii. aine. eff.-sambandhit apoptosis-prerit legand (trail), heey legand mhanoon karya karnare prathine aahe jeey apoptosis navachya peshi mrutyuchya prakriyela prerit karate.
trail heey eka cytokine aahe jeey bahutek samanya uutinchya peshindware tayar kele jaate aanee stravale jaate. heey pramukhyane tumour peshinmadhye, vishisht mrutyu receptors bandhun, apoptosisla karanibhoot tharate. 1990 chya dashakachya madhyapasoon mapatmumabsarkhya anek karkarogvirodhi upcharpaddhatinche lakshya mhanoon trail aanee tyache receptors vaparale jaat aahet. tathapi, 2013 paryant, hyane jaganyacha lakshaniy fayda darshavila nahee. vividh fuffusiy roganmadhye, visheshtah fuffusiy dhamani uchch raktadabamadhye rogkarak kinwa snrakshak ghatak mhanoon dekhil paywat samavisht kelee gelee aahe.
trailla see. dii. 253 (bhinnatecha samooh 253) aanee tii. aine. eff. ess. eff. 10 (tumour necrosis factor (legand) super family, sadasya 10) asehi naav denyat aale aahe.
januk.
manavanmadhye, paywat encode karnare januk gunasutra 3Q26 varr sthit asate, jeey tii. aine. eff. kutumbatil itar sadasyanchya jawal nasate. trail janukachi janukeey rachana andaje 20 keey. bii. paryant pasarleli aahe aanee tyat paach bahya bhag 222,138,42,106 aanee 1245 nucleotides aanee andaje 8.2,3,3 aanee 2.3 keey. bii. chya chaar intron aahet.
trail janukamadhye taata aanee catt boxcha abhav asato aanee pravartak pradeshat pratilekhan ghatkansathi gaata, aii. pii.-1, see./eae. bii. pii., ess. pii.-1, aukt-1, aii. pii. 3, vatane, see. eff.-1 aanee aay. ess. aar. eae. sathee anumanit pratisad ghatak asatat.
aushadhanche lakshya mhanoon trail januk.
vividh prakarchya arbudansah undaranmadhye tick 10 (jeey (jeey prakatikaran karate) chaa tapas karnyat aala.
lahan renu oo. aine. see. 201 mule paywat vyakt hote jyamule karkarogachya kahee peshi nasht hotat.
rachana.
tumour necrosis factor super familichya itar sadasyanna trail samarupata darshavite. heey 281 amino aamlanpasun banalele aahe aanee tyat tyat prakarchya transmembrane prathinanchi vaishishtye aahet. aine-terminal cytoplasmic domain kutumbatil sadasyanmadhye sanrakshit kelele nahee, tathapi, see-terminal bahyakoshikiy domain sanrakshit aahe aanee peshichya prushthbhagapasun proteolytically vibhajit kele jaau shakate. paywat eka samarupak tayar karate jeey teen receptor renunna bandhate.
karya.
trail mrutyu receptors dii. aar. 4 (trail-aar. aay.) aanee dii. aar. 5 (trail-aar. aay.) laa bandhato. apoptosischi prakriya caspage-8 varr avalambun asate. caspage-8, procaspays-3,6 aanee-7 yasah downstream effector caspaces sakriy karate, jyamule vishisht kinesses sakriy hotat. trail receptors dii. see. aar. 1 aanee dii. see. aar. 2 laa dekhil bandhate, jyat cytoplasmic domain (dii. see. aar. 1) nasate kinwa tyat eka kapalele death domain (dii. see. aar. 2) asate. dii. see. aar. 1 heey trail-nutralizing decoy-receptor mhanoon karya karate. dii. see. aar. 2 chey cytoplasmic kshetra karyasheel aahe aanee aine. eff. keey. pii. aii. bii. sakriy karate.
dii. see. aar. 2 vyakt lakshya peshinmadhye, trail binding tyamule aine. eff. keey. pii. aii. bii. sakriy karate, jyamule mrutyu sanket margala virodh karnyasathi aanee/kinwa jaljal vadhavanyasathi dnyat janukanche pratilekhan hote. vegvegalya mrutyunshi (dii. aar. 4 aanee dii. aar. 5) badalanare sambandh asalelya abhiyantriki legandscha vapar aanee decoy receptorscha (dii. see. aar. 1 aanee dii. see. aar. 2) vapar, peshinchya mrutyuchya prakar 1/prakar 2 marganchya sakriyatevar niyantran thevun aanee eka peshi chadhautar niyantrit karoon karkarogachya peshinche nivadak lakshyikaran karnyas anumati deu shakato. pathakachi nakkal karnare luminicent iridium complexes-peptide sankarit, alikadech 'inn vitro' madhye sanshleshit kele gele aahet. heey krutrim paywat nakkal karkarogachya peshinvar dow. 4/dii. aar. aar bandhale jaatat aanee apoptosis aanee necrosis yaa donhidware peshincha mrutyu ghadavun aanatat, jyamule teey karkarogvirodhi aushadhanchya vikasasathi sambhavya umedvar banatat.
aushadhanche lakshya mhanoon trail receptors.
vaidyakeey chachanyanmadhye karkarogachya rugnanchya keval thodya pramanat, mrutyuchya receptorsna lakshya lakshya vividh aushadhanna pratisad deela. karkarogachya anek peshi resha payavatas pratikarshakti vikasit karatat aanee paywat-aadharit upcharanchi parinamkarakta maryadit karatat. 
parasparsanvad.
trail tii. aine. eff. aar. ess. eff. eff. shhee sanvad sadhatana disun aale aahe.

