
mack. pii. eff.

membrain attack complexes/perforin (mack. pii. eff.) super family, jyala kadhikadhi mack. pii. eff./see. dii. see. super family mhanoon sambodhale jaate, tyala purak pranalichya (see. 6, see. 7, see. 8. aii., see. 8. bii. tii. aanee see. 9) aanee perforin (pii. eff.) chya membrain attack complexes (mack) prathinansathi samanya asalelya eka kshetravarun naav denyat aale aahe. yaa prathine kutumbatil sadasya heey chhidra tayar karnare vishari padarth (pii. eff. tii.) aahet. eukariotsmadhye, mack. pii. eff. prathine rogpratikarak shakti aanee vikasat bhoomika bajavtat.
kutumbatil mool sadasya heey see9 aanee perforinche purak aahet, jeey donhi manvi pratikarshaktimadhye karya karatat. graam-negative jivanunchya patalatil chhidre thothavun see9 karya karate. cytotoxic tii peshi aanee vishanujanya sankramit aanee rupantarit peshindware perforin sodale jaate. yavyatirikt, perforin gransimes navachya cytotoxic proteejchya vitaranas parvanagi dete jyamule peshincha mrutyu hoto. donhipaiki konatyahi prathinanchya kamataratemule manvi rog houu shakato. sanrachanatmak abhyasatoon asey disun yete qee mack. pii. eff. kshetra collesterol-aadharit cytolycinsi (see. dii. see.) sambandhit aahe, jeey chhidra tayar karnare vishari padarthanche eka kutumb aahe jeey purvi keval jivanunmadhye astitvat asalyache manale jaat hote.
kutumbe.
2016 chya suruvatiparyant, mack. pii. eff. super familishi sambandhit teen kutumbe aaheth
puttle hallah sankul/perforin (mack. pii. eff.) kutumb.
mack. pii. eff. kshetra asaleli prathine prushthavanshiy pratikarshakti, garbh vikas aanee majjatantu-peshi sthalantarat mahattvachi bhoomika bajavtat. purak aanee perforincha navva ghatak oligomeric chhidre tayar karato jeey anukrame jivanunna mukt karatat aanee vishanu-sankramit peshi nasht karatat. photorhabds luminasons' pasoon jivanu mack. pii. eff. prathinanchi sphatik rachana, plue-mack. pii. eff. nishchit kelee gelee. mack. pii. eff. kshetra sanrachanatmakdrushtya gramm-positive jivanunmadhun chhidra tayar karananya collesterol-aadharit cytolysinsarkhech aahe, jeey soochit karate qee mack. pii. eff. prathine chhidre tayar karatat aanee cytolysinsarkhya peshi patalanna vyatyay aanatat. mack. pii. eff. kutumbatil prathinanchi pratinidhi yadee, vahak vargikaran detabasemadhye aadhalu shakate.
prathine asalelya mack. pii. eff. kshetrachya jaivik bhoomika.
mack. pii. eff. super familishi sambandhit anek prathine vanaspati aanee pranyanchya pratikarshaktimadhye mahattvachi bhoomika bajavtat.
purak prathine see6-see9 yaa sarvanmadhye mack. pii. eff. kshetra asate aanee teey puttle aakraman sankulat ekatra yetat. see6, see7 aanee see8beeta heey naun-lytic asalyache disun yete aanee mcmadhye farshi prathine mhanoon karya karatat. yaulat, see8aii aanee see9 heey donhi peshi leasing karnyas saksham aahet. mack nirmitichya antim tappyat see9 chey mothya chhidramadhye polymerisation samavisht asate jeey gramm-negative jivanunchya bahya patalatil chhidrala thosa marte.
perforin heey cytotoxic tii-peshinmadhil kananmadhye sathavale jaate aanee vishanujanya sankramit aanee rupantarit peshinna marnyasathi jababdar asate. perforin done vegalya yantranandvare karya karate. pratham, see9 pramane, perforinchi uchch sandrata peshinna chhidra karnari chhidre tayar karoo shakate. dusare mhanje, perforin cytotoxic gransimes aii aanee bii lakshyit peshinmadhye pohochavanyas anumati dete. ekada prasarit jhalyavar, gransimes apoptosisla pravrutt karnyas aanee lakshyit peshincha mrutyu karnyas saksham asatat.
vanaspati prathine cadd1 (tii. see. #<aay. dii. 1>) jivanu sansargas vanaspatichya rogpratikarak pratisadat karya karate.
see animone "actineria vilosa" eka ghatak vish mhanoon mack. pii. eff. (aii. vhee. tii. ex.-60aii.; tii. see. #<aay. dii. 1>) prathin vaparte.
dasanchya yazman aanee yakrutamadhye maleriyachya parajivichya aakramanasathi dekhil mack. pii. eff. prathine mahattvachi aahet.
serve mack. pii. eff. prathine sanrakshn kinwa hallyat karya karat naheet. udaharanarth, astrotactin-1 (tii. see. #<aay. dii. 1>) haah sastan pranyanmadhye majjatantu peshinchya sthalantarat aanee epextrin (tii. see. #<aay. dii. 2>) haah sagari archin ("heliocederis erythrograma") chya vikasat guntalela asato. "drosophila" dhadasarkhi prathine (tii. see. #<aay. dii. 1>), jee bhrunachya rachnevar niyantran thevate, tyat mack. pii. eff. kshetra dekhil asate. tyache karya receptor tyrosine keynage signalling pathvemadhye guntalele aahe jeey farak aanee antim peshiche bhavitavya nirdisht karate.
karyatmakaritya vaishishtyahin mack. pii. eff. prathine jivanunmadhye adhunmadhun vitarit kelee jaatat. chlamydiachya anek prajatinmadhye mack. pii. eff. prathine asatat. keetak rogkarak jivanu 'photorhabds luminescence' madhye dekhil mack. pii. eff. prathine asatat, tathapi, haah renu naun-lytic disato.
rachana aanee yantrana.
keetak rogkarak enterobacteria "photorhabds luminasons" madheel prathine, plue-mack. pii. eff. chee ksh-kiran sphatik rachana nishchit kelee gelee aahe (aakruti 1). yaa aakadevarivarun asey disun yete qee mack. pii. eff. kshetra heey claustridium parfringansarkhya (jyamule gass gangreen hote) gramm-positive pathogenic jivanunmadhun collesterolver avalambun asalelya cytolysins (see. dii. see.) tayar karnare chhidra tayar karnyasathi samaan aahe. done kutumbanmadhil amino acid anukram olakh atyant qamee aahe aanee paramparik anukram aadharit deta mining tantrancha vapar karoon sambandh shodhata yet nahee.
asey suchavale jaate qee mack. pii. eff. prathine aanee see. dii. see. tyach prakare chhidre tayar karatat (aakruti 1). visheshtah asey gruhit dharale jaate qee mack. pii. eff. prathine oligomerise houn eka mothe golakar chhidra tayar karatat (aakruti 2). pratyek monomarmadhye eksandh sanrachanatmak badal jhalyanantar done α-helical pradesh shithil houn lakshya peshichya patalavar pasarlelya chaar amphipathic β-strands tayar hotat. see. dii. see. chya mack. pii. eff. prathinanpramane asha prakare beeta-chhidra tayar karnare vishari padarth asatat jeey aanvik chhidra panchsarkhe karya karatat.
mack. pii. eff. super familichya sadasyansathichya itar sphatik rachana aar. see. ess. bii.: aay. madhye aadhalu shakatat.eae.,,,,, 
mack. pii. eff. prathinanche niyantran.
see. dii. 59 sarkhya purak niyamak prathine mack avarodhak mhanoon karya karatat aanee swayam peshinchya viruddha purak ayogya kriyakalapanna pratibandhit karatat (aakruti 3). jaivarasayanik abhyasanni see8aii aanee see9 madheel peptide anukram ughad kele aahet jeey see. dii. 59shhee bandhale jaatat. mack. pii. eff. kshetra sanrachananchya vishleshanatun asey disun yete qee heey anukram helisesachya dusya samoohala nakasha karatat jeey padadyala pasaravanyasathi ulgadatat. tyamule asey suchavale jaate qee see. dii. 59, puttle pasarlelya pradeshanpaiki ekachya sanrachanatmak badalat hastakshep karoon mcla thet pratibandhit karate.
mcshey bandhalelya itar prathinanmadhye see8gmcha samavesh hoto. heey prathin lipocallin kutumbatil aahe aanee see8aiishhee parasparkriya karate. see8aii varr bandhan sthal dnyat aahe, tathapi, mcmadheel see8gmchi achook bhoomika samajoon ghene baakee aahe.
manvi rogat bhoomika.
see9 kinwa mcchya itar ghatakanchya kamataratemule meningococcal meningitissarkhya gramm-negative jivanunmule honanya roganchi sanvedansheelata vadhate. mack. pii. eff. prathinanchya atiakriyashilatemulehi rog houu shakato. sarvat ullekhaneey mhanje, mack avarodhak see. dii. 59 chya kamataratemule purak aanee paroxismal noctornal haemoglobinuriachi atisakriyata hote.
perforinchya kamataratemule samanyatah kautumbik haemophagocytic lymphohysteocytosis (eff. etch. ell. kinwa etch. ell. etch.) haah jivghena vikar hoto. yaa rogache vaishishtya mhanje lymphocytes atee sakriy hone jyamule cytokine madhyasthidvare avayavanche nuksan hote.
mack. pii. eff. prathine dii. bii. see. see. aar. 1 mutrashayachya karkarogamadhye gaath dadapanyache kaam karoo shakatat.
heey kshetra asaleli manvi prathine.
c6; c7; c8a; c8b; c9; fam5b; fam5c; mpeg1;
pii. aar. eff. 1