trophoblastic neoplasm

garbhakalin trophoblastic neoplasia (jee. tii. aine.) haah garbhadharaneshi sambandhit durmil rogancha samooh aahe aanee garbhakalin trophoblastic rogamadhye (jee. tii. dii.) samavisht aahe jyamadhye garbhashayat asamanya trophoblastic peshi vadhatat. jee. tii. aine. chey saumya aanee ghatak jakhmanmadhye vargikaran kele jaau shakate. saumya jakhmanmadhye placental site nodule aanee hydatidiform molescha samavesh hoto tarr ghatak jakhmanmadhye aakramak moll, garbhakalin choreocarcinoma, placental site trauphoblastic tumour (pstt) aanee epitheloid trauphoblastic tumour (ett) yasah chaar upprakar asatat. choreocarcinomache 2 mahattvapoorn upprakar aahet jyat garbhadharana aanee garbhadharana naan karane yancha samavesh aahe aanee teey tyanchya bhinn jaivik vaishishtyandvare aanee purvasuchanadvare vegale kele jaatat. jee. tii. aine. chee chinhe aanee lakshane vyaktinusar aanee rogachya prakaranusar badaltat. tyamadhye masik palichya sambandhat nasalela garbhashayacha raktastrav, otipotatil vedna kinwa daab, mothe garbhashay aanee garbhadharanedarmyancha uchch raktadab yancha samavesh asoo shakato. yaa rogache kaaran adnyat aahe parantu raktdravatil ekoon beeta-manav corionic gonadotropin (β-hcg) varr aadharit gaath olakhane. 
jee. tii. aine. chya vyavasthapanasathi pathologycha aadhava, upchar paryay aanee etch. see. jee. chey nirikshan aavashyak aahe. tyamule, tyavar upchar, garbhashayachhedan aanee eka agent kinwa bahu agent kemotherpidware kele jaau shakatat. rogancha haah gut jaree kemotherapisathi atyant sanvedanshil asala taree, jee. tii. aine. chya prakaravar aanee gaath sharirachya itar bhaganmadhye pasarali aahe qee nahee yavar rognidan avalambun asate.
kaaran aanee jokhim ghatak.
garbhadharanechya trophoblastic neoplasiache (jee. tii. aine.) nemke kaaran adnyat aahe. jee. tii. aine. anekada daadh garbhadharanenantar udbhavate parantu garbhpat aanee mudatpurv garbhadharanesah konatyahi garbhadharanenantar dekhil udbhavu shakate. jaree jokhamiche ghatak arbud vikasit honyavar parinam karoo shakatat, taree bahutek thet rogas karanibhoot tharat naheet. kahee abhyasannusar, 35 varshanpeksha jaast vayachya aanee 20 varshanpeksha qamee vayachya mahilanmadhye sampoorn daadh garbhadharanecha dhoka sarvadhik asato. 45 varshanpeksha jaast vayachya mahilanmadhye dhoka aanakhi jaast asato.
chinhe aanee lakshane.
jee. tii. aine. chee lakshane vyaktinusar badalat rahtil. samaan rog asalelya lokanmadhye serve lakshane soochibaddha nastil.
nidan.
jee. tii. aine. sathichya prarambhik tapasani chachanyanmadhye khaleel goshtincha samavesh hotoh
tumour staging.
jee. tii. aine. chya tappyache moolyankan karnyasathi samanyatah figo (strirogshastra aanee prasutishastrache aantarrashtriy mahasangh) 2000 sharirik avasthapanacha vapar keela jaato.
pahila tappa-garbhashayaparyant maryadit asalela rog
tappa 2-jee. tii. aine. garbhashayachya baher pasarato, parantu too jananendriyachya sanrachaneparyant maryadit asato (ednexa, yoni, rund asthibandhan)
tappa III-jee. tii. aine. haah jananendriyachya dnyat sahbhagasah kinwa tyashivay fuffusanparyant vistarato
chautha tappa-itar serve metastatic sites
pathophysiology.
serve prakarche garbhakalin trophoblastic neoplasia heey nalitoon udbhavtat. garbhadharanedarmyan garbhashayat naal vikasit hote aanee aaee aanee garbh yanchyatil poshak aanee vayoo devanghevaniche teey pahile thikan banate. tyat garbh ghatak aanee matru ghatak asey done ghatak asatat. garbhatil ghatak cytotrophoblast aanee synceteotrophoblastone banalela asato. choreocarcinomache achook rogjanan purnapane samajale gele nahee, parantu abhyasatoon asey disun aale aahe qee cytotrophoblast peshi stame peshi mhanoon karya karatat aanee ghatak swarupat rupantarit hotat. neoplastic cytotrophoblast pudhe ektar madhyavarti trophoblast kinwa cincitiotrophoblastem vegale hote.
upchar.
jee. tii. aine. sathee anek upchar paddhati upalabdh aahet jyat shastrakriya, chemotherapy kinwa hyache sanyojan samavisht aahe. kahee prakarchya rogansathi shastrakriya upchar hii sarvat samanya prarambhik paddhat aahe parantu tee arbudachya tappyavar avalambun asate. samanya shastrakriyechya paryayanmadhye vistar aanee mutramarg aanee garbhashayachi shastrakriya yancha samavesh hoto.
purvasoochana.
ankee sudharit purvanumey gunankan pranali. hii pranali jee. tii. aine. asalelya rugnanche vay, garbhadharana kinwa garbhadharaneche antar, arbudacha aakar kinwa metastes aanee purv chemotherapy yasarkhya anek jokhamichya ghatakanchya aadhare qamee jokhim aanee uchch jokhim mhanoon moolyankan karate. pratyek jokhim ghatakanche moolyankan 0-4 gunanchya staravar kele jaate. tyanantar sankhya jodali jaate aanee ekoon gunank mahilechi jokhim patali tharvato.
mhanoon, kahee abhyasanni asey darshavile aahe qee jarr karkarog yakrut kinwa mendumadhye pasarla asel kinwa upchar suru jhalyavar beeta-etch. see. jee. chee patali 40,000 maay. yuu./miilii. peksha jaast asel, chemotherapy ghetalyanantar karkarog parat yeil kinwa upcharapurvi 4 mahinyanpeksha jaast kaal lakshane/garbhadharana jhaali asel tarr hii sthitee burry karane katheen aahe.
mahamarishastra.
abhyasanusar, jee. tii. aine. uttar america kinwa europechya tulanet ashiyamadhye adhik varanvar aadhalato. 2020 paryant, uttar america aanee europemadhil 40,000 garbhadharanepaiki 1 teey aagney ashiya aanee japanmadhil 40,000 garbhadharanepaiki anukrame 9.2 aanee 3.3 paryant coriocarcinomachya nondavalelya ghatana aahet. mahamarishastriy abhyasanni nondavale aahe qee 15 varshanpeksha qamee vayachya aanee 45 varshanpeksha jaast vayachya prajnan vayachya tokanvar asamanya gamatogenesis aanee varanvar garbhadhanamule hydatidiform moll udbhavate aanee yaa vayat garbhadharana haah hydatidiform molsathi eka dhokadayak ghatak aahe. 35 varshannantar dhoka vadhato aanee 45 varshannantar 5-10 patinni dhoka vadhato.
sanshodhan.
alikade, jee. tii. aine. rogjanan adhik samajoon ghenyachi sadhane pradan karnyasathi, asha neoplasiache yogya nidan, vyavasthapan aanee upcharansathi epigenetic badal aanee aanvik jivashastra tantre lagoo kelee jaau shakatat. anty-angiogenesis therapy aanee aanvik lakshyit karkarog upcharpaddhatinchi pragati aushadh pratikar asalelya rugnanmadhye upcharatmak drushtikon sudharnyas saksham asel. sadhya vaidyakeey vyavasthet chemotherapy aanee hysterectomycha vapar keela jaat asala taree jee. tii. aine. barah karnyasathi sharirvirodhi aanee januk upcharansah vividh upcharancha vapar karnyacha prayatna keela jaat aahe. yavyatirikt, jee. tii. aine. chya upcharasathi sadhya anuvanshikdrushtya abhiyantriki kelelya majjatantu moolpeshi vaparoon januk vitaran sadhananchi tapasani kelee jaat aahe aanee mageel abhyasanni arbud vadhivar lakshaniy pratibandhatmak parinam darshavila aahe.

