
anek bahya tvacha vadhicha ghatak-sarkhya kshetra 8

"megef8" jyala multiple epidermal groth factor-sarkhya domain 8 mhanoon dekhil olakhale jaate, heey eka prathine coding januk aahe jeey eka paas membrain prathine encode karate, jeey vikasatmak niyaman aanee cellular sampreshanat sahbhagi honyasathi olakhale jaate. too manavanmadhil 49 vya khulya vachan chaukativar (19q13.2) gunasutra 19 varr sthit aahe. emm. jee. eff. 8 sathee done samaroop rachana olakhalya jaatat, jyaa 67 amino acid indelane bhinn asatat. isophorm 2 splies aavrutti (yaa sampoorn prushthavar vishleshan keleli) 2785 amino acid lamb aahe aanee vastumanat 296.6 keey. dii. ell. asalyacha andaj aahe. isophorm 1 haah 2845 amino acidney banalela aahe aanee tyache vajan 303.1 keey. dii. ell. hoil assa andaj aahe. sphot shodhancha vapar karoon, ortholog pramukhyane sastan pranyanmadhye aadhalale, parantu megef8 heey aprushthavanshi aanee mashanmadhye dekhil sanrakshit kele jaate aanee kvachitach pakshi, sarpatanare prani aanee ubhaycharanmadhye sanrakshit kele jaate. anek bahya bahya vikas ghatak-sarkhya kshetransathi eka lakshaniy mahattvachi samantar rachana mhanje aii. tii. aar. aine. ell. 1 (aakarshan-sarkhe 1), jeey eka ekal paas transmembrane prathine dekhil aahe, jyamadhye megef 8 sarkhich anek pramukh vaishishtye aanee rachana aahet, jeey germanytil headleberg yetheel european aanvik jivashastra prayogshaledware aayojit kelelya sadhya modular architecture sanshodhan sadhanane (smart) soochit kele aahe. davya-ujavya swarupachi rachana aanee avyav nirmiti yasarkhya anek vikasatmak prakriyanmadhye emm. jee. eff. 8 haah eka pramukh ghatak asalyacha andaj vartavanyat aala aahe. sadhya, sanshodhakanna emm. jee. eff. 8 ess. aine. pii. utparivartan heey sutar lakshansamuchchay upprakar 2 chey kaaran asalyache aadhalale aahe.
januk.
utkranti aanee orthologs.
eka byanpaiki uchch sanrakshit prathine, emm. jee. eff. 8 neey pii. pasoon ortholog sanrakshit kele aahet. paniscus teey aine. vectainsis. ortholog heey sastan prani, ubhaychar, maase, keetak, crustatian aanee aksherukanmadhye aadhaltat. aakadevarichya sanghatanet asey disun aale qee jasjasa kaal manav aanee ortholog yanchyatil vichalan vadhat gela, tastashi anukramachi olakh qamee hott gelee. 
paralog.
emm. jee. eff. 8 chee eka dnyat paralog aaheh aii. tii. aar. aine. ell. 1. aii. tii. aar. aine. ell. 1 prathin hii emm. jee. eff. 8 chya andaje nimmya lambichi asate aanee tyat cube domain aanee transmembrane sequences samaan sanrakshit domain aahet. heey lakshat ghene mahattvache aahe qee aii. tii. aar. aine. ell. 1 heey anek pakshi aanee ubhaycharanmadhye aadhalate, jethe emm. jee. eff. 8 konatyahi pakshyanmadhye aadhalat nahee aanee fakt eka ubhaychar aahe.
pravartak.
genomaticscha eldorado (HTTP:// Ww.genomatics.dii/) yaa januk pravartak databasene, "emm. jee. eff. 8" sathee daha vegvegalya sambhavya pravartakancha andaj vartavala. pravartak id kramank jee. ex. pii. _ 1262882 aanee pratilekhan id jee. ex. tii. _ 22531930 asalelya pravartakacha andaj sarvoch vishvasane vartavanyat aala hota. haah pravartak gunasutra 19 chya adhik strandver sthit aahe, joou nucleotide 42829077 teey 42830497 paryant aahe, jyamule too 1421 nucleotide lamb kram banato. pravartak kram janukatil pratilekhan prarambh codens overlap hoto.
pratilekhan ghatak.
genomaticsdware "emm. jee. eff. 8" pravartak pradeshat ekshehoon adhik pratilekhan ghatak bandhansthale sapadtil assa andaj vartavanyat aala hota. sarvat aatmavishvasane andajit kelelya pahilya vees ghatakanmadhye khaleel goshtincha samavesh hotoh
prathine vastukala.
prathamik rachana.
megef8 ektar 2845 amino acid (isophorm 1) kinwa 2778 amino acid (isophorm 2) neey banalele aahe. isophorm 2 madhye 700-766 madhoon 67 amino acid kadhoon takale jaatat, jeey tyachya qamee lambisathi jababdar asate; anyatha, done isophorm samaan asatat. protein sequence softwareche sankhyikeey vishleshan, sapscha vapar karoon, amino acid bayas nirdharit karane shakya jhaale. isophorm vanmadhye cysteine aanee glycine samruddha asate aanee isolucin aanee licinechi kamatarata asate. megef8 chya isophorm 2 madhye systeinchi patali khoop jaast, glycinechi patali madhyam pramanat jaast aanee isolucin aanee licinechi patali qamee asalyache aadhalun aale.
cysteine avasheshanchi uchch patali paripakv prathinanchya dumadalelya sanrachanet aadhalanaya asankhya diasulphide bandhanmadhye yogdan dete. ekoon, megef8 madhye jivachya kramanusar ph 6.7 teey 7.0 darmyan asato. manvi megef8 chaa ph 6.4 aahe. haah jawaljawal tatasth ph prathinanna yogyaritya dumadanyas saksham karato aanee vikrutikaran rokhato. 20 orthologschya bahuvidh anukram sanrekhanadvare aadhalanari vees sarvat sanrakshit amino aaml, cube aanee transmembrane domenmadhye aadhalali.
duyyam rachana.
yuu. see. ess. see. jivashastra karyapithatil andaj software pelane soochit kele qee emm. jee. eff. 8 pramukhyane beeta-folded sheetsney banalele aahe, jyat adhunmadhun lahan alfa helics vibhag asatat. aatmavishvas patali vadhavat, andajanchi tulana aanee pushti karnyasathi pail aath bhinn andaj karyakram vaparte. beeta-folded sheets eae. jee. eff.-domain, kelch domain aanee eae. jee. eff.-laminine domens anek pramukh domenvar aadhaltat. pelmadhil hii mahitee fayare2 neey kelelya duyyam rachana aanee 3 dii sanrachanechya andajanshi dekhil sambandhit hotee.
purvanumey pramukh kshetra aanee vaishishtye.
megef8 madhye anek prakarchi vaishishtye, kshetra aanee rachana asateel, jyaa prathinanche karya, rachana aanee sthan yanmadhye mahattvachi bhoomika bajavtat, assa andaj vartavala jaato. heey takta 1 madhye soochibaddha aahet. smart vishleshanadvare aadhalanari karye, tasech aine. see. bii. aay. sanrakshit domain shodhat samavisht aaheh
trutiyak rachana.
megef8chya trutiyak sanrachaneche eka pramukh vaishishtya mhanje tyacha 7-blade beeta propeller joou tyachya dii1keey3ia3 sanrachanatmak kshetrat aadhalanaya kelch motifdware tayar hoto, joou scopdware olakhala gela hota. scopney asehi soochit kele qee megef8 madheel beeta-propeller haah galactose auxidase super familicha sadasya aahe. saat bladepacky pratyek chaar adakalelya beeta-folded motifspasoon banaleli aahe. heey lakshat ghene dekhil mahattvache aahe qee jaree anek phosphorylation sthalancha andaj uchch aatmavishvasane vartavala gela asala taree itar anek sthalakrutik andaj (i.eae. diasulphide bandh, glycosylation, itar bahyakoshikiy vaishishtye), yaa andajanna samarthan dett naheet.
abhivyakti.
geoprofileschya matey, aine. see. bii. aay. pasoon hriday snayu aanee garbhachya menduchya uutinmadhye uchch staravar emm. jee. eff. 8 vyakt jhalyache aadhalun aale aahe. yaa geoprophylne asehi soochit kele qee tapasalelya itar serve uutinmadhye megef8 madhyam teey madhyam patalivaril abhivyakti patalivar asalyache aadhalun aale. aine. see. bii. aay. geoprophile detane manavanmadhye emm. jee. eff. 8 sathee uutinchya abhivyakticha aalekh dekhil pradan keela, joou ujavikade pradarshit keela jaato, vishisht thikane aanee abhivyaktichi patali pudhe spasht karato.
cellular prakriyanmadhil karya aanee yantrana.
aanvik karya.
biogps <ref naav = "10.1186/gb-2009-10-11-r130"> januk ontology mahitinusar, megef8 haah receptor kriyakalap, calcium aayan bandhan, prathine bandhanamadhye sakriy sahbhagi aahe.
jaivik prakriyanmadhye bhoomika.
biogpsdware januk ontology mahitiche vishleshan jaivik prakriyanchi yadee tayar karnyas saksham hote, jyapaiki pratyekamadhye emm. jee. eff. 8 mahattvapoorn bhoomika bajavateh
anumanatmak parasparkriya.
khaleel taktyat, smartseedy3 vagalata serve andajit parasparsanvadanna done-sankarit padadyavaril prayogik mahiticha aadhar aahe. hii mahitee nextprote databases aanee akhand databases yaa donhidware samarthit aahe. sarvoch aatmavishvas moolyasah done parasparsanvadanna stringmadhil majkoor-khanitoon sapadalelya samgridvare dekhil samarthan dile jaate. ektritpane, heey vajvi uchch aatmavishvasane aahe qee laal rangatil prathine emm. jee. eff. 8 shhee parasparkriya kareet aahet aanee madhyam aatmavishvasane qee hiravya rangatil prathine emm. jee. eff. 8 shhee parasparkriya karatat. nilya rangatil prathinansathi aatmavishvasachi patali khoopach qamee aahe, jyacha arth assa houu shakato qee done-sankarit chachanine chukiche sakaratmak pradan kele aahe, kinwa teey pratyakshat parasparkriya kareet aahet.
paryayi vibhajan, utparivartan aanee phenotypic prabhav.
splies prakar.
chaar prathamik vibhajanache prakar aanee tyanche farak khalee varnan kele aahet (label khalee dilelya pratimeshi sambandhit aahet):
aha exon 13 chee vibhagani kelee aahe. sanlagn karyarat sankalpanatmak bhashantar pahata, asey disun yete qee exon 3 konatyahi vaishishtya, kshetra, rachana kinwa aechya itar karyatmak vibhagasathi code karat nahee aanee tyamule kadachit megef 8 prathinanchya karyasathi mahattvachi nahee. haah prakar vishleshan kelelya megef8 chya splies modelshee sambandhit aahe.
bah exon 1-6 chee jodani; yaa exonmadhye cube domain, done psi domain, dii1keey3aay3 structural domain aanee kelch repeat yasah anek pramukh domain aanee motif aahet. yamule sanrachanatmak vibhaganshivay prathinanchi khotee patani houu shakate aanee vikasachya ghatananmadhye sahbhag rokhu shakate (pii. ess. aay. aanee cube. chee haanee). ajunahi signal aanee tii. emm. eae. emm. aahe tyamule ajunahi anshatah karya karnyas saksham asoo shakate
 c: d1k3ia3 sanrachanatmak kshetracha kahee bhag exon 29 madhye rahato, parantu kelch punaravrutti kadhoon taknyat aalee aahe, jyamule sanrachanatmak samasya udbhavu shakatat. tasech yaa prakaramadhye jawaljawal 3 pii. ess. aay. kshetra aahet aanee exon 32-35 madhye qamee guntaguntiche kshetra aahe, jeey yaa prakarala peshimadhye karya karnyas anumati deu shakate, parantu patalat konatehi sanket kinwa tii. emm. eae. emm. thevu shakat nahee jenekarun samanya karya honar nahee.
deeh haah prakar exon 36-40, excised 41 aanee eka lahan 42 exon aahe. tyat eae. jee. eff. calcium kshetra aanee eae. jee. eff./eae. jee. eff. sarkhya kshetrancha samavesh aahe. 41 chey nuksan karyat mothya pramanat badal karel kaaran tyat tii. emm. eae. emm. vibhag aahe. 41 kuthe haravale aahet aanee 42 kuthe todale aahet yavar teey avalambun aahe.
samanya utparivartan.
snyaps.
aine. see. bii. aay. janukdarshanadware aadhalanare anek ess. aine. pii. aahet, jeey emm. jee. eff. 8 madhye missense kinwa mook utparivartan karatat. tathapi, teen ess. aine. pii. utparivartan heey suthar lakshansamuchchay 2 chee karane mhanoon twig aanee itaranni olakhale.<sandarbh naav = "10.1016/j.ajhg.2012.08.027> </ref> teen ess. aine. pii. utparivartan aaheth gly199 teey aarg; aarg1499 teey tyanche; sair2367 teey gly. twigchya lekhamadhye eka purak deta sanch samavisht aahe joou ess. aine. pii. chya sabhovatalachya pradeshanche aanee ess. aine. pii. jyaa domenmadhye aahe tyaa kshetrache ekadhik anukram sanrekhan darshavito. gly199 teey aarg utparivartan heey ii. jee. eff.-domenmadhye sthit aahe; tyachya utparivartanasathi aarg1499 heey 7-blade beeta-sheet propellermadhil kelch domenmadhye sthit aahe; sair2367 teey gly heey ii. jee. eff.-laminine domenmadhye sthit aahe. yogyaritya dumadaleli prathine aanee tyanche karya rakhanyasathi heey kshetra mahatvache aahe.
sutar lakshansamuchchay 2.
rogashi sambandhit adhik vistrut tapashilansathi sutar lakshansamuchchayala bhet dya. megef8 madheel anuvanshik utparivartan heey yaa durmil anuvanshik lakshansamuchchayache pramukh kaaran asalyache aadhalun aale aahe.
pratikool phenotypic parinam.
twig aanee itaranni dilelya vruttanusar, vikasadarmyan sadosh parshvikikaranashi megef8 madheel utparivartan sambandhit asalyache aadhalun aale aahe. sutar lakshansamuchchay upprakar II asalelya vyaktinchya samanya vaishishtyanmadhye khaleel goshtincha samavesh hotoh 
sadhyache sanshodhan.
sutar lakshansamuchchay 2 sathee upchar kinwa upchar vikasit karnyasathi sadhya konatehi sanshodhan kele jaat nahee. sanshodhak ajunahi emm. jee. eff. 8 madheel bindu utparivartananche kaaran samajoon ghenyacha prayatna kareet aahet jyacha parinam yaa atyant durmil anuvanshik rogat hoto.