jee. ess.-441524

jee. ess.-441524 heey eka nucleoside analogue antiviral aushadh aahe jeey gilliod vidnyanane vikasit kele aahe. heey antiviral prodrug remdesivirche mukhya plazma metabolite aahe aanee manvi rugnanmadhye tyache ardhayushya sumare 24 taas aahe. remedicivir aanee jee. ess.-441524 heey donhi paliv manjarinna sansargjanya peritonitis (phip) sathee jababdar asalelya manjar corona vishanuchya prabhedanviruddha prabhavi 'inn vitro' asalyache aadhalun aale, joou gharguti manjarinna prabhavit karnara eka pranghatak pranaligat rog aahe. remdessivirchi chachani manjarinmadhye kadhich jhaali nahee (jaree kahee pashuvaidya aata teey detat), parantu jee. ess.-441524 haah fipsathi prabhavi upchar asalyache aadhalun aale aahe aanee gilliodne pashuvaidhyakiy vaparasathi yaa aushadhacha parwana denyas nakar dilyane adhikrut eff. dii. aii. chee manjuri naan midalyanantarhi tyacha mothya pramanat vapar keela jaato. jee. ess.-441524-obeldesivirche isopropylaster pro-drugg gilliod vidnyanane vikasit kele aahe aanee teey teey tappyatil vaidyakeey chachanyanmadhye aahe. vigonvita jeevan vidnyanane eka vikrut swaroop vikasit kele aahe aanee teey teey tappyatil vaidyakeey chachanyanmadhye dekhil aahe.
vapar aanee sanshodhan.
phip samanyatah pranghatak asalyane aanee konatehi manjur upchar upalabdh naslyamule, jee. ess.-441524 kalvya bajarat vikale gele aahe aanee paliv pranyanchya malakanni prabhavit manjarinvar upchar karnyasathi vaparale aahe, jaree gilliod vidnyanane pashuvaidhyakiy vaparasathi aushadhacha parwana denyas nakar deela aahe. yaa uddeshasathi tyachi parinamkarakta anek chachanyanmadhye nirnayakpane darshavili gelee aahe, jyat kshetriy chachanyancha samavesh aahe aanee agadi bahu-pranali kinwa majjasansthecha sahbhag asalelyansarkhya adhik klisht prakarchya fipmadhye dekhil.
jee. ess.-441524 heey peshi sanvardhanatil sars-cove-2 viruddha remdesivirsarkhech kinwa tyahoon adhik shaktishali aahe, kahee sanshodhak assa yuktivad karatat qee jee. ess.-441524 heey covid-19 chya upcharasathi remdesivirpeksha changle asel. uddhrut kelelya vishisht fayadhyanmadhye sanshleshan sulabhata, mootrapind aanee hepatotoxicity qamee karane, tasech tondawate prasooti karanyachi kshamata (jeey yakrutachi kharab sthirata aanee first paas chayapachayamule remdesivirpasun vagalalele aahe) yancha samavesh aahe. sarvajanik aarogya samarthan gut, sarvajanik nagrik, yanni eka khulya patrat dii. etch. etch. ess. aanee gilliod yanna covid-19 chya upcharasathi jee. ess.-441524 chee chaukashi karnyache aavahan kele, asey suchavat qee gilliod heey remdesivirchya dirgh bauddhik sampada ayurmanashi sambandhit aarthik hetunsathi asey karat navhate, jyache paytant 2035 chya aadhi sampatat. sars-cove-2 viruddha thet parinamkarakta covid-19 chya mouse modelmadhye darshavili gelee.
jee. ess.-441524 chee deuterium sudharit aavrutti tayar karnyat aalee aahe aanee wuhan institute auph virologychya sadasyansah eka chamoone peshi sanwardhan aanee under model donhimadhye purv-chikitsalayin parinamkarakta darshavili aahe. shanghay janshi biosciences upakampanila 30 janewari 2023 roji chinchya rashtriy vaidyakeey utpadane prashasanakadun covid-19 asalelya praudhanvar upchar karnyasathi vhee. vhee. 116 sathee sashart manjuri midali.
jee. ess.-441524 heey anek puravathadarankadun atishay uchch shuddhatemadhye (aine. emm. aar. aanee etch. pii. ell. see. dware 99 takke) sanshodhan rasayan mhanoon vikale jaate. sanshodhanachya uddeshane asha vikrimadhye petantache ullanghan hott nahee, jyala yu. aii. neey pushti dilee hotee.ess. sarvoch nyayalayacha nirnay. tathapi, uchch shuddhata asoonahi, eff. dii. aii. niyamannusar, asha rasayananche utpadan eff. dii. aii. see. jee. emm. pii. pramanit paristhitit kele jaat naslyamule, tyanna vaidyakeey chachanyansathi parvanagi nahee.
jee. ess.-441524 heey thet nirogi mansamadhye dile gele aahe, jyamadhye plasmachi sarvadhik sandrata 12 yuu. emm. paryant pohochali aahe, jee sanskratitil sars-cove-2 viruddha kriyakalapansathi aavashyak asalelya ekagratechya 10 putt aahe.
aushadhashastra.
pharmacodynamics.
jee. ess.-441524 nucleoside heey nucleoside kinesesdware phosphorylated kele jaate (bahudha adenosine kinness (aii. dii. keey.), jeey sanrachanatmakdrushtya samaan ribavirinala phosphorylate karnare enzyme aahe) aanee nantar nucleoside-diaphosphate kinesdware (aine. dii. keey.) sakriy nucleotide triphosphate swarupat punha phosphorylated kele jaate. jee. ess.-441524, jee. ess.-443902 chey triphosphate heey dekhil remdesivirdware tayar kelele jaiv-sakriy vishanuvirodhi ghatak aahe, parantu nantarchyapeksha vegalya jaivarasayanik yantranedvare tayar kele jaate.
pharmacokinetics.
jee. ess.-441524 haah 1 '-sayano-pratisthapit adenosine analogue aahe. drut jalvichhedan (1 tasapeksha qamee ardha ayushya) aanee tyanantar defosphorylationmule sirammadhye firnare heey remdesivirche pramukh chayapachay aahe.
sarvajanik nagarikanchya patrala pratisad mhanoon, national institute auph healthchya drugg discovery arm, national center phaur advancing translational sciences (aine. see. aii. tii. ess.) neey paddhatshir tapasatmak naveen aushadh suru kele aahe, jeey anek purv-vaidyakeey prajatinmadhye pharmacokinetics prayog saksham karate aanee manavanmadhye (octobermadhye) (parinam adyap prakashit jhalele naheet). maukhik jaivupalabdhata kutryanmadhye utkrusht, undaranmadhye changli, parantu cyanomolagus gair-manvi narvanaranmadhye samanya asalyache aadhalun aale. purv-vaidyakeey mahitivarun manvi maukhik jaivupalabdhatecha andaj lavane hii vidnyanapeksha adhik qalaa aahe aanee anek prajatinchya mahitichya pratimanavar avalambun aahe. itar nucleoside pratirupanchya vaidyakeey aanee purv-vaidyakeey mahiticha sandarbh bindu mhanoon ghetalyas, jee. ess.-441524 chee manvi maukhik jaivupalabdhata kutryamadhye uchch bindu mhanoon aanee manvetar narvanaranmadhye narvanaranmadhye darmyan kuthetari padane apekshit aahe. jee. ess.-441524 chey remdessivirche aanvik vajan nimmyapeksha thode qamee asalyane, jaree manvi tondawate jaivupalabdhata 50 takke asali, taree (udaharanarth) ribavirinashi tulana karata, teey raktala remdesivirchya samaan matreitkech sakriy chayapachay deil (udaharanarth, 100 mii. gra.). aine. catscadoon nuktyach prasiddha jhalelya aakadevarivarun asey disun yete qee jee. ess.-441524 heey sumare 100 micronometerche jastit jaast plazma sandrata (see. emm. aii. ess.) asalelya kutryanmadhye 1000 mii. gra./kilone kinwa peshi sanvardhanatil vishanuviruddhachya kriyakalapansathi aavashyak asalelya sandratepeksha sumare 100 putt jaast sahan kele jaate.
jee. ess.-441524 chey nirmulan ardh-ayushya cyanomolagasmadhye sumare 2 taas asate, jeey manavanmadhye nondavalelya 24 tasanpeksha khoopach qamee asate. jarr aushadh manvi tondi vaparasathi manjur asel tarr ardha ayushya divasatoon ekdach doses ghene soochit karate.
krutichi yantrana.
jee. ess.-441524 chey antahkoshik tri-phosphorylation tyache sakriy 1 '-sayano-pratisthapit adenosine triphosphate analogue dete, jeey navjat vishanujanya aar. aine. aii. pratilekhanmadhye samavisht karnyasathi antarjansheel aine. tii. pii. ess. shhee spardha karoon aanee aar. aine. aii.-avalambun asalelya aar. aine. aii. polymerage vilambit sakhali samaptila chalana deuun vishanujanya aar. aine. aii. pratikrutimadhye thet vyatyay aanate. 
sahishnuta.
"crandell rees fellin kidney (see. aar. eff. keey.) peshinmadhil 'inn vitro' prayoganmadhye jee. ess.-441524 heey 100 microne ghanatevar vishari nasalyache aadhalun aale, jeey sanvardhit see. aar. eff. keey. peshi aanee sankramit macrofagemadhye fipavi pratikruti rokhanyat 100 putt prabhavi aahe. manjarinvaril vaidyakeey chachanya soochit karatat qee heey aushadh changlya prakare sahan kele jaate, prathamik dushparinam mhanje injection mishranachya aamlatamule tvachechi jaljal.
covid-19 sathee upchar mhanoon tyachi upayuktata upayuktata kahee sanshodhakanni remdesivirpeksha fayade darshavile aahet, jyat yakrutachya vishaktatecha abhav, ardhayushya aanee adhik dirghkalaparyant sampark (aii. oo. see.) aanee barech swast aanee sope sanshleshan yancha samavesh aahe.

