
mitsunobu pratikriya

mitsunobu pratikriya hii eka sendriya pratikriya aahe jee triphenylphosphine aanee diethyl azodicarboxylate (mrut) kinwa diasopropyl azodicarboxylate (died) sarkhya azodycarboxylate vapar karoon estersarkhya vividh karyatmak gatanmadhye alcoholche rupantar karate. jaree mrut aanee diad heey sarvat samanyapane vaparale jaat asale taree, itar vividh prakarche azodicarboxylates upalabdh aahet jeey vyayam aanee/kinwa shuddhikaran sulabh karatat aanee kahee prakarananmadhye, adhik moolbhut nucleophilescha vapar sulabh karatat. yacha shodh oyo mitsunobu (1934-2003) yane lavala. eka vishisht niyamavalimadhye, tetrahydrophuran kinwa itar yogya dravkamadhye (udaa.jee. diethyl ether), barfachya snanadvare 0°seey. paryant thund qaraa, haloohaloo tii. etch. eff. madhye virghalalele mrut ghala, nantar kahee taas kholichya tapmanavar dhavalun ghya. alcohole phosphineshy pratikriya karoon eka changla gut tayar karato aanee nantar nucleophile visthapit hott asatana classic ess. aine. 2 paddhatine stereochemistrychya ulatya prakriyetoon jaato. jevha azodicarboxylate ichchit nucleofilevaji baher padananya gatala visthapit karate tevha eka samanya side-product tayar hote. jarr nucleophile purese amleey nasel (pii. keey. aii. 13 peksha mothe asel) kinwa steric kinwa electronic nirbandhanmule purese nucleophilic nasel tarr heey ghadate. nitrogen nucleofilecha vapar karoon yaa abhikriyechya badalala fukuyama-mitsunobu mhanatat.
anek samikshane prakashit jhaali aahet.
pratikriya yantrana.
mitsunobu abhikriyechi pratikriya yantrana baryapaiki guntaguntichi aahe. madhyasthanchi olakh aanee teey kaay bhoomika bajavtat haah charchecha vishay rahila aahe.
suruvatila, triphenyl phosphine (2) diethyl azodicarboxylatevar (1) beaten madhyavarti 3 tayar karnara nucleophilic hallah karato, joou carboxylic aamlala (4) deprotonate karoon aayan jodee tayar karato. aayan jodee 5 chee nirmiti khoop vegwan asate. 
yantranecha dusra tappa phosphorus-kendrit prastavit aahe, mrutanche hydrazinemadhye rupantar jhaale aahe. madhyavarti 8-11 chey gunottar aanee aantarparivartan heey carboxylic aaml pii. keey. aii. aanee dravak dhruviyatevar avalambun asate. jaree anek phosphorus madhyavarti upasthit asale taree, madhyavarti 8 varr carboxylate aayancha hallah haah ichchit utpadan 12 aanee triphenylphosphine auxide (13) tayar karnara ekmev utpadak marg aahe.
oxyphosphonium madhyavarti 8 chee nirmiti mand gatine hote aanee alcoxideware sulabh hote. tyamule, pratikriyecha ekoon darr carboxylate ksharata aanee dravanadvare niyantrit keela jaato.
abhikarmakanchya jodanicha kram.
mitsunobu abhikriyechya abhikarmakanchya jodanicha kram mahattvacha asoo shakato. samanyatah, tetrahydrophuran kinwa itar yogya dravkamadhye (udaa.jee. diethyl ether), barfachya snanadvare 0°seey. paryant thund qaraa, haloohaloo tii. etch. eff. madhye virghalalele mrut ghala, nantar kahee taas kholichya tapmanavar dhavalun ghya. jarr heey ayashasvi tharale tarr beetachi purvarachana kelyane changle parinam miloo shakatat. btine purvarupat aananyasathi, 0°seey. varr tetrahydrophuranmadhy triphenylphosphinemadhy mrut ghala, tyanantar alcohole aanee shevati aaml ghala.
vividhata.
itar nucleophilic karyatmak gut.
carboxylic aamlanvyatirikt itar anek karyatmak gut nucleophils mhanoon kaam karoo shakatat. pratikriya yashasvi honyasathi, nucleofilemadhye pii. keey. aii. 15 peksha qamee asane aavashyak aahe.
badal.
utpadanache pruthakkaran sope karnyasathi aanee itakya rasayanik kachyache utpadan talhanyasathi mool abhikarmak sanyogat anek badal vikasit kele gele aahet. mitsunobu abhikriyechya eka prakarat raal-baddh triphenylphosphine vapar keela jaato aanee mrut aivaji dye-"turt"-butylazodicarboxytchillate vapar keela jaato. oxidised triphenylphosphine raal galanadvare kadhale jaau shakate aanee dye-"turt"-butylazodicarboxylate upautpadan trifluoroacetic acids upchar karoon kadhale jaate. broos etch. lipshutzne mrut, dye-(4-chlorobenzyl) azodicarboxylate (dii. see. aii. dii.) chaa paryay vikasit keela aahe, jithe hydrazine up-utpadan nispandan karoon sahajpane kadhale jaau shakate aanee dii. see. aii. dii. madhye punarvapar keela jaau shakato.
eka badal dekhil nondavala gela aahe jyamadhye mrut utprerak viruddha stoikiometric pramanat vaparale jaau shakate, tathapi yaa prakriyet hydrazine up-utpadanache auksidikaran karnyasathi stoikiometric (diasetoxiodo) benzincha vapar karane aavashyak aahe.
denton aanee sahakanyanni mitsunobu abhikriyecha redox-neutral prakar nondavala aahe, joou thurr sakriy karnyasathi phosphorus (3) utprerak vaparato, nucleophilic hallyat ultyachi khatri karato aanee panyache up-utpadan kadhanyasathi deane-stark trap vaparato.
phosphorene abhikarmak.
tsunameeda "aanee itar."asey dakhavun dile aahe qee ekhadi vyakti triphenylphosphine aanee diethyl azodicarboxylate ekach abhikarmakat ekatra karoo shakateh phosphorene yelide. donhi (cyanomethylene) trimethylphosphorene (see. emm. emm. pii., aar = mea) aanee (cyanomethylene) tributylphosphorene (see. emm. bii. pii., aar = bii. yuu.) visheshtah prabhavi siddha jhaale aahet.
yelide qamee karnara ghatak aanee aadhar donhi mhanoon karya karate. acetonitrile (6) aanee trialkilfosphine auxide (8) hii upautpadane aahet.
vapar.
eril etherchya sanshleshanat mitsunobu pratikriya lagoo kelee gelee aaheh
yaa vishisht abhikriyakansah mrut saha rupantaran ayashasvi hote kaaran hydroxyl gut keval kamkuvatpane amleey asato. tyaeivaji sambandhit "1,1 '-(azodicarbonyl) dipiperidine" (edapi) vaparale jaate, jyapaiki btine madhyavarti haah eka majboot aadhar aahe. phosphine heey polymer-samarthit triphenylphosphine (pii. ess.-pii. etch. 3) aahe.
yaa abhikriyecha vapar quinine, colchisin, saren, morphene, stigmetellin, udistomine, oseltamivir, stricknin aanee nufaramine yanche sanshleshan karnyasathi keela gela aahe.