
pramukh suvidha denara super family

pramukh suvidha denare super family (emm. eff. ess.) heey puttle parivahan prathinanche eka super family aahe jeey chemiosmotic pravanatechya pratisadat peshi patalanvar lahan dravkanchi halchal sulabh karate.
karya.
pramukh suvidha denare super family (emm. eff. ess.) heey puttle prathine aahet jee lakshyit tharanchya aayat kinwa niryatisathi jivanachya serve rajyanmadhye sarvatra vyakt kelee jaatat. emm. eff. ess. kutumb pramukhyane sakharechya sevanamadhye karya karate asey moolatah manale jaat hote parantu tyanantarchya abhyasatoon asey disun aale qee aushadhe, chayapachay, oligosaccharides, amino acid aanee auxianian heey serve emm. eff. ess. kutumbatil sadasyandvare vahoon nele jaat hote. hii prathine lakshya thurr (uniporter) chya vidyutarasayanik pravahacha vapar karoon urjavanpane vahtook chalavatat kinwa jethe vahtook dusya tharanchya halchalishi jodali jaate tethe sahavahatukdar mhanoon karya karatat.
dumadun ghya.
emm. eff. ess. vahatukdarachi moolbhut putt 12 chya aaspas kinwa kahee prakarananmadhye, 14 transmembrane helics (tii. emm. etch.) bandhali jaate, jyamadhye done 6-(kinwa 7) helics bundle asatat, jeey aine aanee see terminal homologous domendware tayar hotat, jeey vistarit cytoplasmic loopdware jodalele asatat. prathinanchya packche done ardhe bhag clam-shale paddhatine ekmekanviruddha asatat, transmembrane helices aanee bahyakoshikiy loopchya tokanvar parasparsanvadvare seal karatat. yamule padadyachya madhyabhagi eka mothee jaleey pokali tayar hote, jee paryayipane peshiras kinwa periplasm/bahyakoshikiy jagesathi khulee asate. yaa jaleey pokalila astar karnare amino-aaml heey aahet jeey tharanna bandhatat aanee vahak vishishtata paribhashit karatat. anek emm. eff. ess. vahatookdar heey inn vitro aanee inn vivo paddhatindware diamer manale jaatat, yaa oligomerizationsathy karyatmak bhoomika suchavanyasathi kahee purave aahet.
yantrana.
bahutek emm. eff. ess. vahatukichya vahatukivar aadharit asaleli paryayi-pravesh yantrana shastriyadrushtya 'rocker-switch' yantrana mhanoon varnan kelee jaate. yaa pratimanat, vahak ektar bahyakoshikiy jagesathi kinwa peshidravyasathi ughadato aanee ekach velee vahakacha viruddha chehara seal karato, jyamule padadyamarge satatcha marg rokhala jaato. udaharanarth, uttam abhyas kelelya emm. eff. ess. vahkamadhye, lessie, lactose aanee proton samanyatah jaleey fatyatil vishisht sthalanshi periplasmpasoon bandhale jaatat. yamule bahyakoshikiy chehara bund hoto aanee peshirasik bajoo ughadate, jyamule peshimadhye thurr pravesh karoo shakato. thurr sodalyanantar, vahak periplasmic facing abhimukhtashi punarvapar karato.
emm. eff. ess. kutumbatil niryatdar aanee antiporter samaan pratikriya chakr palatat, jaree niryatdar cytoplasma thurr bandhatat aanee teey bahya koshikeey kinwa periplasmic jaaget baher kadhatat, tarr antiporter pratyek sanrachanatmak badal ghadavun aananyasathi donhi rajyanmadhye thurr bandhatat. bahutek emm. eff. ess. sanrachana thurr bandhanisah mothya, kathor shareer sanrachanatmak badal soochit karatat, tarr nitrate vahak nark sarkhya lahan tharanchya babatit halchali lahan asoo shakatat.
vahtook.
emm. eff. ess. kulyandware utprerit kelya gelelya samanyikrut vahtook pratikriya pudhilpramane aaheth
thurr vishishtata.
suruvatila jaree procariotspasoon teey sastan pranyanparyant sanrakshit kelele karya, sakhar vahak mhanoon olakhale jaat asale, taree emm. eff. ess. kutumb heey super familidware vahoon nenyat yenanya tharanchya mothya vividhatesathi ullekhaneey aahe. yamadhye lahan auxianiyanpasun teey peptidechya mothya tukadyanparyantcha samavesh aahe. itar emm. eff. ess. vahak nivadaktechya abhavasathi, aushadhanche aanee zenobioticsche vistrut varg baher kadhanyasathi ullekhaneey aahet. hii thurr vishishtata mukhyatve vishisht bajuchya sakhalyandvare nirdharit kelee jaate jee jaleey pishavila padadyachya madhyabhagi reshet thevatat. vishisht jaivik mahatva asalelya eka tharala anekada vahak kinwa kutumbache naav denyasathi vaparale jaate, tarr saha-parivahan kelele kinwa galalele aayan kinwa renu dekhil asoo shakatat. yamadhye panyache renu kinwa jodanare aayan samavisht aahet jeey urjavanpane vahtook chalavatat.
sanrachana.
anek emm. eff. ess. vahatukdaranchya sphatik sanrachananche vaishishtya darshavile gele aahe. pahilya rachana glycerol 3-phosphet/phosphet vinimayak jee. ell. pii. tii. aanee lactose-proton simporter lesichya hotya, jyanni prathine kutumbachi ekoon rachana spasht karnyasathi kaam kele aanee emm. eff. ess. vahtook yantrana samajoon ghenyasathi prarambhik namune pradan kele. yaa prarambhik sanrachananmule itar emm. eff. ess. sanrachana sodavalya gelya aahet jyaa pratikriya chakratil tharanchi vishishtata kinwa sthitee spasht karatat. sodavalelya prarambhik emm. eff. ess. sanrachana jivanuvahu vahakanchya hotya, tarr alikadech pahilya eukariotic sanrachananchya sanrachana prakashit karnyat aalya aahet. yamadhye burshijanya phosphet vahak pipt, vanaspati nitrate vahak nrt1.1 aanee manvi glucose vahak glute1 yancha samavesh aahe.
utkranti.
moolbhut emm. eff. ess. vahatookdar dumadiche mool sadhya jordar vadavivadakhali aahe. kahee emm. eff. ess. kutumbanmadhye atirikt done tii. emm. etch. asale taree, sadhya manyataprapt asalelya serve emm. eff. ess. pargmyanmadhye ekach polypeptide sakhalimadhye done sahaa-tii. emm. etch. kshetra asatat. puravyanvarun asey soochit hote qee emm. eff. ess. pargaman heey suruvatichya procariotsmadhil eka antarjanik pratikruti ghatanemule udbhavale. yaa ghatanemule (gruheet) adim 6-helics diamermadhun 12 transmembrane helics topology tayar jhaali. shivay, tii. emm. ess. 2 aanee tii. emm. ess. 3 madheel changlya prakare sanrakshit emm. eff. ess. vishisht rachana aanee tii. emm. ess. 8 aanee tii. emm. ess. 9 madheel sambandhit parantu qamee changlya prakare sanrakshit rachana heey jawaljawal olakhalya gelelya 300 peksha jaast emm. eff. ess. prathinanche vaishishtya asalyache siddha hote. tathapi, adim 6-helics kshetrache mool mothya vadat aahe. kahee karyatmak aanee sanrachanatmak purave asey suchavatat qee heey kshetra sopya 3-helics domenmadhun udbhavale aahe, yaa gruhitkala samarthan denanya jaiv-mahitee kinwa jatijanya puravyancha abhav aahe.
vaidyakeey mahatva.
emm. eff. ess. kutumbatil sadasya manvi shariravidnyanat madhyavarti aahet aanee aniyamit krutee, aushadhanchi vahtook kinwa aushadhanchya pratikaradvare anek roganmadhye mahattvachi bhoomika bajavtat. oat 1 vahak vishanuvirodhi upcharpaddhatimadhye madhyavarti asalelya anek nucleoside analogchi vahtook karato. pratijaivikancha pratikar haah anekada emm. eff. ess. pratirodhak janukanchya kruticha parinam asato. emm. eff. ess. vahatukdaranmadhil utparivartan heey neurodegerative rog, menduche raktavahinyanche vikar aanee glucose sathavan rog dekhil karanibhoot asalyache aadhalun aale aahe.
roganche utparivartan.
anek manvi emm. eff. ess. vahatukdaranmadhye rogashi sambandhit utparivartan aadhalale aahet; yuniprotmadhye bhashya kelele khalee soochibaddha aahet.
manvi emm. eff. ess. prathine.
manavanmadhye anek emm. eff. ess. prathine aahet, jithe tyanna dravak vahak (ess. ell. see.) aanee asamanya ess. ell. see. mhanoon olakhale jaate. aaj 52 ess. ell. see. kutumbe aahet, jyapaiki 16 kutumbanmadhye emm. eff. ess. prathine samavisht aahet; ess. ell. see. 2,1516,17,18,19, ess. ell. see. 21,22,29,33,37,40,43,45,46 aanee 49. asamanya ess. ell. see. hii emm. eff. ess. prathine aahet, jee ess. ell. see. saha anukram samanata aanee utkrantivadi mool samayik karatat, parantu tyanna ess. ell. see. mool pranalinusar naav dile jaat nahee, jee hugo januk namkaran pranali (etch. jee. aine. see.) pasoon udbhavate. serve aprakrutik ess. ell. see. tapshilvar soochibaddha aahet, parantu teey asey aaheth emm. eff. ess. dii. 1, emm. eff. ess. dii. 2aii, emm. eff. ess. dii. 2bii, emm. eff. ess. dii. 3, emm. eff. ess. dii. 4aii, emm. eff. ess. dii. 4bii, emm. eff. ess. dii. 5, emm. eff. ess. dii. 6, emm. eff. ess. dii. 6ell, emm. eff. ess. dii. 8, emm. eff. ess. dii. 9, emm. eff. ess. dii. 10, emm. eff. ess. dii. 11, emm. eff. ess. dii. 12, emm. eff. ess. dii. 13aii, emm. eff. ess. dii. 14aii, emm. eff. ess. dii. 14bii, anak93aii, anak 93bii1, ess. vhee. dii. 2bii, ess. vhee. vhee. oo. pii., ess. pii. ess. aine. ess. 1, ess. pii. ess. ess. 2, ess. pii. ess