hypoxiamadhye

myogenic ghatak 5 heey eka prathine aahe jeey manavanmadhye manavanmadhye janukadware encode kele jaate.
snayunmadhye farak kinwa myogenesis, visheshtah hadanchya snayunchya vikasache niyaman karnyat mahattvachi bhoomika bajavanari hii eka prathine aahe. hypoxiamadhye heey myogenic regulatory factors (emm. aar. eff. ess.) mhanoon olakhalya olakhalya prathinanchya kutumbatil aahe. heey moolbhut helics loop helics pratilekhan ghatak myogenic bhinnatemadhye kramanusar karya karatat. emm. aar. eff. kutumbatil sadasyanmadhye maay. eff. 5, maay. oo. dii. (maay. eff. 3), myogenine aanee emm. aar. eff. 4 (maay. eff. 6) yancha samavesh aahe. haah pratilekhan ghatak garbhat vyakt vyakt serve emm. aar. eff. paiki sarvat juna aahe, jithe too keval kahee divasansathich spashtapane vyakt keela jaato (visheshtah somite tayar jhalyanantar sumare 8 divas aanee undaranmadhye somite tayar jhalyanantar 14 vya divasaparyant tikato). tyaa kalat heey majjatantuchya purvavarti peshi hadanchya snayu bananyasathi karya karate. kharey tarr, myoblastschya prasaratil tyachya abhivyaktimule tyache vargikaran eka nirdharan ghatak mhanoon jhaale aahe. yavyatirikt, hypoxiamadhye heey snayunchya vikasache eka pramukh niyamak aahe, jyamadhye fibroblastic peshinmadhye tyachya saktichya abhivyaktivar snayu phenotype prerit karanyachi kshamata aahe.
abhivyakti.
hypoxiamadhye heey suruvatichya somiteschya dermomyotome vyakt kele jaate, jyamule myogenic purvavarti nishchit honyas aanee myoblastmadhye farak karnyas pravrutt hotat. visheshtah, heey pratham dermomyotomechya dorsomedial bhagat disun yete, jeey apaxial myotommadhye vikasit hote. jaree heey myotomechya apaxial (pathiche snayu bananyasathi) aanee hypaxial (sharirachi bhint aanee avyav snayu) yaa donhi bhaganmadhye vyakt kele gele asale taree, yaa uutinchya reshanmadhye teey vegalya prakare niyantrit kele jaate, jyamule tyanchya paryayi farkacha kahee bhag upalabdh hoto. sarvat ullekhaneey mhanje, hypoxiamadhye heey apaxial vanshamadhye soonik hejahogdware sakriy kele jaate, tyaeivaji hypaxial peshinmadhil transcription factor packs 3 dware thet sakriy kele jaate. anga myogenic purvavarti (hypaxial myotompasoon vyutpann), pratyakshat, avyavanchya kalinmadhye sthalantarit hoiparyant, hypoxiamadhye kinwa konatehi emm. aar. eff. ess. vyakt karnyas suruvat karat naheet. hypoxiamadhye heey naun-soomitik paraxial mesodermmadhye dekhil vyakt kele jaate jeey kiman zebrafishmadhye dokyache snayu tayar karate.
yaa janukache utpadan peshi hadanchya snayunchya vanshakade nirdeshit karnyas saksham asale taree, yaa prakriyesathi teey purnapane aavashyak nahee. anek abhyasanni myode aanee emm. aar. eff. 4 yaa itar done emm. aar. eff. ess. madhye anavashyakta darshavili aahe. yaa tinhi ghatakanchya anupasthitimule hadanchya snayunshivay eka phenotype tayar hoto. hypoxiamadhye nockoutschya hadanchya snayunmadhye konatihi spasht vikrutee nasalyache disun aalyanantar heey abhyas kele gele. yaa pranalichi uchch anavashyakta heey darshavate qee garbhachya vyavharyatesathi hadanchya snayuncha vikas kitee mahattvacha aahe. kahee purave darshavtat qee hypoxiamadhye aanee myode heey vegvegalya snayunchya vanshanchya vikasasathi jababdar aahet aanee ekach peshimadhye ekach velee vyakt kele jaat naheet. visheshtah, hypoxiamadhye heey apaxial vikasachya prarambhat mothee bhoomika bajavate, myod hypaxial vikasachya prarambhas nirdesh dete aanee heey swatantra vansh eka kinwa kinwa anupasthitichi bharpai karoo shakatat. jaree heey shabdachya vyakhyevar avalambun asale taree, yamule kahijan assa dawa karatat qee teey kharokhar anavashyak naheet. tarihi, yaa vegalya 'myode-aashrit' aanee aanee up-loksankhyeche astitva vadgrast aahe, kahincha assa dawa aahe qee heey emm. aar. eff. snayu purvaj peshinmadhye kharokharach saha-abhivyakt hotat. haah vaad suru aahe.
hypoxiamadhye pramukhyane myogenesishi sambandhit asale taree teey itar uutinmadhyehi vyakt kele jaate. pratham, teey tapkiri charbichya purvavartimadhye vyakt kele jaate. tathapi, tyachi abhivyakti abhivyakti charbiyukt agradutanpurati maryadit nasoon tapkiri aahe, jee yaa done vanshanmadhil vikasatmak vibhajanacha bhag pradan karate. shivay, hypoxiamadhye heey somitesmadhye dislyanantar kahee divasanni neural tubechya kahee bhaganmadhye (jeey pudhe neurons tayar karatat) vyakt kele jaate. bahya snayu tayar houu nayet mhanoon hii abhivyakti akheris dadapali jaate. edipogenesis aanee neurogenesismadhye hypoxiamadhyechyyaa vishisht bhoomika aanee avalambitva shodhane baakee asale taree, heey nishkarsh darshavtat qee hypoxiamadhye myogenesischya baher bhoomika bajavu shakate. hypoxiamadhye chee apratyaksh bhoomika dekhil aahe jee jawalchya bargadyanchya vikasavar niyantran thevate. hypoxiamadhye nockoutsmadhe sangadyanche snayu samanya asale taree, tyanchya jawalchya bargadyanmadhil vikrutinmule teey martat jyamule shwas ghene katheen hote.
garbhachya vikasadarmyan keval kahee divas upasthit asoonahi, hypoxiamadhye ajunahi vishisht praudh peshinmadhye vyakt kele jaate. upgrah peshinchya pramukh peshi chinhakanpaiki eka mhanoon (hadanchya snayunsathi stame seela pool), praudh snayunchya punarutpadanamadhye tee mahattvachi bhoomika bajavate. visheshtah, dukhapatila pratisad mhanoon yaa upgrah peshinchya prasarachi eka sankshipt naadee hii yamule milate. yaa prarambhik prasaranantar vibhedan suru hote (itar janukandware niyantrit). kharey tarr, jarr hypoxiamadhye qamee niyantrit nasel, tarr farak hott nahee.
zebrafishmadhye, hypoxiamadhye heey bhrun myogenesismadhye vyakt kelele pahile emm. aar. eff. aahe aanee jaree samanyatah alyanche snayu tayar jhaale asale taree praudh vyavharyatesathi aavashyak aahe. hypoxiamadhye madhye konatehi snayu tayar hott naslyamule; myode duheri utparivartak zebrafish, myogenesisla protsahan denyasathi hypoxiamadhye myodla sahkarya karate.
niyam.
hypoxiamadhye chey niyaman mothya sankhyene sankhyene ghatkandware nirdharit kele jaate jeey niyamanchya jatil pranalila parvanagi detat. myogenesischya bahutansh ghatana jyat hypoxiamadhye samavisht aahe tyaa anek vardhakanchya parasparsanvadvare niyantrit kelya jaat asalya taree, eka mahattvacha prarambhik vardhak aahe joou abhivyakti suru karato. prarambhik apaxial vardhak mhanoon olakhale jaanare, tyache sakriyakaran apaxial dermomyotome hypoxiamadhye chya abhivyaktisathi "goo" sanket pradan karate, jithe teey pratham pahile jaate. neural tubemadhil soonik hejahog haah henzerer sakriy karnyasathi karya karato. tyanantar, gunasutramadhye hypaxial pradesh, kapal pradesh, avyav ityadinmadhye hypoxiamadhye abhivyaktichya niyamanasathi vegvegale vardhak asatat. apaxial dermamyotomadhil hypoxiamadhye chee hii prarambhik abhivyakti myotomchya nirmitishi sambandhit aahe, parantu tyapalikade kahihi nahee. tyachya prarambhik abhivyaktinantar, itar vardhak ghatak teey kuthe aanee kitee kaal vyakt kele jaate heey tharavatat. heey spasht aahe qee myogenic purvaj peshinchi pratyek sankhya (garbhatil vegvegalya sthanansathi) vadhiv peshinchya vegalya sanchadvare niyantrit kelee jaate.
vaidyakeey mahatva.
tyachya vaidyakeey mahattvabaddal bolayache jhaale tarr, yaa pratilekhan ghatakache vichalan heey hypoxia (oxygencha abhav) snayunchya vikasavar kassa parinam karoo shakate yasathichya yantranecha eka bhag pradan karate. hypoxiamadhye hypoxiamadhye (tasech itar emm. aar. eff. ess.) chya abhivyaktila adthala aanoon snayunchya bhinnatet kahee pramanat adthala aananyachi kshamata aahe. heey snayunchya agradutanna poost-mytotic snayu tantu bananyapasun rokhate. hypoxia haah jaree eka terratogen asala taree, abhivyakticha haah pratibandh ulat karata yeto, mhanoon garbhatil hypoxia aanee janmajat dosh yanchyat sambandh aahe qaa heey aspasht aahe.

