vaidyakshastratil carbon nanotubes

aajchya vaidyakeey sanshodhanachya jagaat carbon nanotubes (see. aine. tii.) khoop prachalit aahet aanee rog upchar aanee aarogya dekharekhisathi karyaksham aushadh vitaran aanee jaiv samvedan paddhatinchya kshetrat tyanche uchch sanshodhan kele jaat aahe. carbon nanotube tantradnyanamadhye aushadh vitaran aanee jaivasinsing paddhatinmadhye sudharana karanyachi kshamata asalyache disun aale aahe aanee asha prakare carbon nanotubeny alikadech aushadh kshetrat rus ghetala aahe.
aushadh vitaran aanee jaiv samvedan tantradnyanamadhye see. aine. tii. chaa vapar kelyane aushadhanmadhye kranti ghadavun aananyachi kshamata aahe. eka-bhinti asalelya nanotubesche (ess. aine. tii.) karyatmakakaran vidravyata vadhavate aanee tumour lakshyikaran/aushadh vitaran karyaksham karnyas anumati dete. heey gandulanna cytotoxic honyapasoon aanee rogpratikarak peshinchya karyat badal karnyapasoon rokhate.
karkarog haah rogancha eka gut aahe jyamadhye peshi asamanyapane vadhatat aanee vibhajit hotat, haah see. aine. tii. aushadh vitaranala too kassa pratisad deto yachya sandarbhat pahilya vaparlya prathamik roganpaiki eka aahe. sadhyachya karkarog upcharpaddhatit pramukhyane shastrakriya, kiranotsarg upcharpaddhati aanee chemotherapy yancha samavesh hoto. upcharanchya yaa paddhati sahasa vednadayak asatat aanee pratikool dushparinam nirman karnyavyatirikt samanya peshi nasht karatat. aushadh vitaran vahane mhanoon see. aine. tii. neey vaparlelya paramparik aushadhanpeksha qamee matresah vishisht karkarogachya peshinna lakshya karanyachi kshamata darshavili aahe, jee peshi maranyat titakich prabhavi aahe, tathapi nirogi peshinna haanee pohochavat nahee aanee dushparinam lakshaniyaritya qamee karate. madhumeh asalelya rugnandware raktatil sakharevar dekhrekh thevanyachya sadhyachya paddhati samanyatah aakramak aanee anekada vednadayak asatat. udaharanarth, eka paddhatimadhye eka chhotya suimadhye ektrit kelela satatcha glucose sensor samavisht asato joou darr kahee divasanni glukojchya patalivar laksh thevanyasathi tvachekhali ghalane aavashyak asate. asate paddhatimadhye glukojchya dekhrekh pattyancha samavesh aahe jyavar rakt lavane aavashyak aahe. yaa paddhati keval aakramakach naheet tarr tyaa chukiche parinam dekhil deu shakatat. asey darshavile gele qee satat glucose sensarsdware midavalelya glukojchya mojmapanpaiki 70 takke 10 takke kinwa tyahoon adhik bhinn aahet aanee 7 takke 50 takkyanhun adhik bhinn aahet. uchch vidyutarasayanikdrushtya sulabh prushthbhagache kshetrafal, uchch vidyut chalakata aanee upayukt sanrachanatmak gunadharmanni atyant sanvedanshil gair-aakramak glucose detectormadhye eka-bhinti asalelya nanotubes (ess. aine. tii.) aanee bahu-bhinti asalelya nanotubes (emm. aine. tii.) chaa sambhavya vapar darshavila aahe.
see. aine. tii. gunadharm.
see. aine. tii. madhye anek adviteey rasayanik, aakar, prakashik, vidyut aanee sanrachanatmak gunadharm aahet jeey tyanna anukrame vividh roganchya upcharansathi aanee manvi sharirachya rakt patali aanee itar rasayanik gunadharmanche aakramak nasalele nirikshan karnyasathi aushadh vitaran aanee jaiv samvedan munch mhanoon aakarshak banavtat.
vidyut aanee sanrachanatmak.
carbon nanotubes tyanchya sanrachanenusar dhatuche kinwa ardhchalak asoo shakatat. heey grapheenchya samamiti aanee adviteey electronic sanrachanemule aahe. dilelya (aine, emm) nanotubesathi, jarr aine = emm, nanotube dhatucha asel; jarr aine-emm haah 3 chaa gunakar asel, tarr nanotube atishay lahan band gaps ardhchalak aahe, anyatha nanotube haah madhyam ardhchalak aahe. asha prakare serve armchair (aine = emm) nanotube dhatuche aanee nanotube (5,0), (6,4), (9,1) ii. aahet. ardhchalak aahet. asha prakare, kahee nanotubemadhe tambyapeksha jaast chalakata asate, tarr itar siliconsarkhe vagatat.
aayami.
tyanchya nanoscale parimananmule, carbon nanotubemadhil electron vahtook quantum prabhavandvare hoil aanee keval nalichya akshavar prasarit hoil. jaiv sanvedansambandhichya babatit heey vidyut aanee sanrachanatmak gunadharm see. aine. tii. laa sarvottam seva detat kaaran see. aine. tii. madheel vartaman badal teey shodhanyasathi tayar kelelya vishisht jaivik ghatakanna soochit karoo shakatat. see. aine. tii. heey lahan (aine. emm. scale) asatat, tyamule teey shariratil vishisht rog peshinna aushadhanche lahan doses deu shakatat, tyamule dushparinam qamee hotat aanee paramparik aushadhanpramane nirogi peshinna haanee pohochavate, tarr rog peshinchi lakshyikaran karyakshamta sudharate.
rasayanik.
lipids karyasheel kelyavar see. aine. tii. madhye vidravyata vadhalyache disun aale aahe jyamule manvi shariratoon tyanchi halchal sulabh hoil aanee sharirachya mahattvachya avyavanchya marganmadhye adthala yenyachi jokhim dekhil qamee hoil. optical gunadharmancha vichar karata, see. aine. tii. heey nir (jawal-infrared) prakashasarkhya vishisht varnakrameey khidkyanmadhye majboot optical shoshan darshavit asalyache darshavile gele aahe aanee jevha tumour peshisah karyasheel kele jaate tevha vishisht bandhan ghatakanmule rogacha nivadak naash houu shakato (udaa.jee. karkarog) aushadh vitaran anuprayoganmadhye nir asalelya peshi. tyanchyat changle rasayanik gunadharm aahet.
aushadh vitaran aanee karkarog upcharanmadhye see. aine. tii.
aushadh vitaran heey vegane vadhanare kshetra aahe jeey aata nanotube tantradnyanacha laabh ghet aahe. sadhya aushadh vitaranasathi vaparlya vaparlya pranalinmadhye dendreamers, polymer aanee liposomes yancha samavesh aahe, parantu carbon nanotubes uchch aushadh bharnyachi kshamata aanee changlya peshi pravesh guna asalelya prabhavi sanrachanansah kaam karanyachi sandhee sadar karatat. heey nanotube aushadh container mhanoon vaparlya vaparlya mothya aateel aakarmanasah, asankhya karyatmak jodanisathi mothya pailu gunottarasah aanee peshidvare sahajpane sweekarle jaanyachi kshamata saha karya karatat. tyanchya nalee sanrachanemule, carbon nanotubes end caps kinwa tyashivay tayar kele jaau shakatat, yacha arth assa qee end capsashivay aushadh jethe thewale jaate tyaa aateel bhagat adhik sulabh asel. sadhya carbon nanotube aushadh vitaran pranalimadhye, vidravyatecha abhav, guthalya hone aanee ardhayushya yasarkhya samasya udbhavtat. tathapi, carbon nanotube kshetratil pudhil pragatisathi sadhya yaa serve samasyankade laksh dile jaat aahe aanee tyat badal kele jaat aahet. aushadh vitaranasathi nanovactor mhanoon carbon nanotubeche fayade tethech aahet jithe yaa sanrachananche peshi grahan prabhavipane darshavile gele hote jethe parinam pramukh hote, heey darshavitat qee vishisht nanotube aushadhansathi nanovicals mhanoon qamee hanikarak asoo shakatat. tasech, aushadhache aavaran paanee pasaravane, changli jaivupalabdhata aanee vishaktata qamee karnyasathi darshavile gele aahe. renunche aavaran heey samagri sathavan anuprayog tasech bharit renunche sanrakshn aanee niyantrit prakashan dekhil pradan karate. yaa sarvanmule aushadhanchya changlya vitaran aadharavar parinam hoto, jithe panyat vidravyata vadhane, vishaktata qamee hone, ardhayushya tikavoon thevane, peshincha pravesh vadhavane aanee grahan karane yasarkhya itar anek pragativar pudhil sanshodhan aanee samaj sudharu shakate, jyaa serve sadhya naveen aahet parantu avikasit kalpana aahet.
boron neutron capture therapy.
narayan hosmane aanee tyachya tyachya alikadech boron neutron pakadanyasathi eka naveen drushtikon vikasit keela aahe.
paryayi carboren-sanlagn panyat panyat eka-bhinti carbon nanotubescha vapar karoon karkarogachya upcharanmadhye upchar. nitrine cyclooditiondware ekal bhinti carbon nanotubeschya (ess. doubleu. see. aine. tii.) bajuchya bhintinna paryayi see. 2 bii. 10 carboren pinjare yashasviritya jodanyat aalee. ethanolche refluxing kartana soodiyam hydroxide pratikriyedvare, yaa yaa carboren pinjaryanche shirachhed, jodalelya ess. doubleu. see. aine. tii. barobar, purn jhaale. bases refluxchya darmyan, nitrine aanee ess. doubleu. see. aine. tii. dware tayar keleli teen-sadasyanchi ring panyat virghalanari ess. doubleu. see. aine. tii. tayar karnyasathi ughadali gelee hotee jyamadhye bajuchya bhinti bhinti carboren units aanee ethoxide moities yaa donhidware karyanvit kelya gelya hotya. serve naveen sanyuge eae. aii., same, tame, yuu. vhee., aine. emm. aar. aanee aay. aar. speektra aanee rasayanik vishleshanadvare darshavili gelee hotee. yapaiki eka nanotubever nivadalelya ootee vitaran abhyasat, ((naa +) [1-mea-2-((ch2) 4nh-)-1,2-c2b9h10] [oet]) n (swct)} (va), asey disun aale aahe qee boron anoo rakt aanee itar avayavanpeksha tumour peshinmadhye adhik kendrit asatat, jyamule karkarogachya upcharat prabhavi boron neutron capture therapisathi tumour peshinmadhye boron pohochavanyasathi teey eka aakarshak nanovical banate.
nivadak karkarogachya peshincha naash.
carbon nanotubescha vapar nivadak karkarogachya peshinchya nashasathi bahuuddeshiy jaivik vahak aanee jawalche infrared agent mhanoon keela jaau shakato. jaivik pranali 700-teey 1,100-nm jawalchya infrared (aine. aay. aar.) prakashasathi atyant pardarshak asalyache dnyat aahe. sanshodhakanni dakhavun dile qee yaa vishesh varnakrameey khidakitil eka-bhinti asalelya carbon nanotubes (ess. aine. tii.) chey majboot optical shoshan, jeey ess. aine. tii. chaa eka aantarik gunadharm aahe, tyacha vapar bahukriyashil nanotube jaivik vahakanna parvadanyasathi jiwant peshinmadhil nanotubeschya optical uttejanasathi keela jaau shakato. tyanni nanotubedware jiwant helah peshinmadhye vahoon nenyat aalelya oligonucleotidecha vapar keela. neer lesar spandananmule suru jhalelya endosomal futanyane oligonucleotides peshi kendrakat sthanantarit hotat. satatchya neer kiranotsargamule vitromadhye shimpadyachya atee sthanik ushnatemule peshincha mrutyu jhaala. folletchya bhagasah shimpadyache karyatmakakaran, follet receptor tumour markers label kelelya peshinmadhil shimpadyanche nivadak antargatkaran aanee receptor-mukt samanya peshinna haanee naan pohochavata nir-prerit peshi mrutyu, yamule nivadak karkarogachya peshincha naash sadhya jhaala. asha prakare, carbon nanotubeschya vahtook kshamata aanee yogya karyatmak rasayanshastra aanee tyanche aantarik optical gunadharm ektrit kelyane aushadh vitaran aanee karkarog upcharansathi naveen nanomaterialsche naveen varg houu shakatat.
gaath lakshyit karane.
karkarog upcharansathi undaranmadhil carbon nanotubeschya lakshyikaranasathi inn vivo biodistribution aanee atyant karyaksham tumourver sanshodhan kele gele aahe. inn vivo positron utsarjan tomography (paliv prani), ex vivo jaiv vitaran aanee raman spectroscopidware undaranmadhil redio-labelyukt shimpadyanchya jaivavibhajanavar tapas keela jaat aahe. asey aadhalun aale qee polyethylene glycol (pegg) asalele phospholipids karyasheel asalele shimplay aashcharyakarakpane 'inn vivo' sthir asatat. peng sakhalichya lambicha, gavatachya jaivavibhajan aanee parisancharanavar parisancharanavar parinamacha abhyas karnyat aala. prabhavipane pegilated shimpadyanni tulanene dirgh rakt parisancharan vel aanee reticuloendothelial pranalidware (rez) qamee grahan darshavile. arginine-glycine-espartic acid (aar. jee. dii.) peptideshy jodalelya pegg chenane lepit kelelya sontsdware undaranmadhil integreen positive tumourche karyaksham lakshya sadhya kele gele. uchch gaath sathanyache shrey chhalachya bahugunit prabhawala dile gele. undaranchya uutinmadhye nanotubechya upasthitichi thet tapasani karnyasathi aanee redio-label-aadharit parinamanchi pushti karnyasathi shimpadyanchya raman raman vaparlya gelya.
biosensor mhanoon see. aine. tii.
see. aine. tii. network bayo-strace sensors.
taana kinwa taana anubhavtana ekach nanotubemadhe vidyut pratikarshaktimadhye badal hoto. haah pesoresistive prabhav nanotubemadhun pravah badalat asato, joou lagoo kelelya tanavache achook praman mojanyasathi mojala jaau shakato. anek ativyapi nanotubechi ardh-yadruchchik sthitee anek pesoresistive nanotubepasoon banalele vidyut vahak jaale tayar karate. jarr nirmitidarmyan nalichi lambi aanee coone yancha farak dnyat aanee niyantrit karata yet asel, tarr jaalyatil konatyahi done bindunmadhil apekshit pravah nirdharit karnyasathi igensystemcha drushtikon vaparla jaau shakato. plate, clamp, screw kinwa hadala jodalelya itar fixation upkarnavaril bharacha parinam mojoon hadey barey honyachi sthitee nirdharit karnyasathi nalikeche jaale orthopedic plates, clamps aanee skrumadhye aanee hadanvaril graftmadhye embed kele jaate. barey jhalele haad bahutansh bhaar sahan karel tarr barey naan jhalele haad sthiratechya upkarnavar bhaar dhaklel jyamadhye nanotube network pratirodhaktemadhye jhalela badal moju shakate. vidyut preranadvare mapan wireless paddhatine kele jaate. yamule doctoranna rugna barey honyache achook moolyankan karata yete aanee rugnala heey dekhil kalate qee prabhavit bhag kitee tanav surakshitpane sahan karoo shakato. wolfcha niyam soochit karato qee haad surakshit pramanat tanawala sakaratmak pratisad dete, jeey yogya upcharansathi aavashyak asoo shakate.
glucose shodhanare biosensor.
atisanvedanshil glucose shodhanyasathi carbon nanotube-plazma polymer-aadharit amperometric biosensor tayar kele gele aahet. done amperometric enzyme biosensor tayar karnyat aale. ekamadhye eka bhint nanotube aanee itar bahubhint nanotube hote, tathapi, plazma-polymerised thean films (pii. pii. eff. ess.) donhimadhye samavisht karnyat aale hote. glucose auxidase (dev) yaa enzymeche mishran aanee see. aine. tii. philm 10-aine. emm. jaad acetonitrile pii. pii. eff. ess. neey sandwich kele gele. eka pii. pii. eff. thurr sonyachya vidyutdhruvavar jamaa karnyat aala. see. aine. tii. thurr aanee dev yanchyatil vidyutarasayanik sanvad sulabh karnyasathi, see. aine. tii. varr auxigen plazma vaparoon upchar kele gele. eka-bhinti asalelya see. aine. tii. asalelya upkaranane bahu-bhinti asalelya see. aine. tii. peksha jaast sanvedansheelata darshavili. glucose biosensormadhye atisanvedanshilata (40 micro miimii-1 semee-2 chee sanvedansheelata, 0.992 chaa parasparsambandh gunank, 0.025-1.9 mimichi resheey pratisad shreni, ess/aine = 3, + 0.8 vhee viruddha ag/agcl yethe 6.2 micrometerchi shodh maryada) aanee jalad pratisad (kamal pratisadachya 95 takkeparyant pohochanyasathi <4 sekand) disun aala. yaa uchch kamgiriche shrey see. aine. tii. madhye utkrusht vidyut utprerak kriyakalap asatat aanee electron hastantaran vadhavtat aanee pii. pii. eff. ess. aanee/kinwa see. aine. tii. sathee plazma prakriya hii eka enzyme-anukool munch aahe, mhanje.eae.dev aanee see. aine. tii. madheel parasparsanvadachi eka yogya rachana.
dii. aine. aii. shodhanare biosensor.
dii. aine. aii. shodhanyasathi sanrekhit carbon nanotube ultrasensitive biosensor vikasit karnyat aala. biosensorchi rachana aanee nirmiti hii ekatmik ekal-strand dna (ssdna) saha sanrekhit ekal bhint carbon nanotubes (swcnt) varr aadharit hotee. banavat atee-sanvedanshil biosensorne prushthbhag sthir ess. ess. dii. aine. aii. aanee lakshya ess. ess. dii. aine. aii. darmyan dii. aine. aii. sankarikaranacha label-mukt vastavik-vel electronic shodh pradan keela. purak aanee lakshya ess. ess. dii. aine. aii. nucleotide bases jodyanmadhil sankarikaran gatishastramule ess. doubleu. see. aine. tii. madhye inject kelelya bases jodyanmadhil sthanik charge nirmiti jhaali jyamule ess. doubleu. see. aine. tii. vidyut chalakatemadhye shodhanyayogya badal jhaala. silicon-silicon auxide aadharit feeled effect transistermadhye (eff. eae. tii.) ardh-vahak vahini mhanoon karyatmak ess. doubleu. see. aine. tii. chya ektrikaranadvare haah chalakata badal vidyutdrushtya vadhavanyat aala. mageel langmuir dii. aine. aii. gatishastra gananevar aadharit, ess. doubleu. see. aine. tii.-dii. aine. aii. sanvedakanchi andajit sanvedansheelata patali paramparik fluorescent aanee sankarikaran parikshananpeksha lakshaniyaritya jaast hotee.
see. aine. tii. sudharit electrode biosensor.
carbon nanotube (see. aine. tii.) sudharit electrodavar aadharit sukshmajiv jaivasanvedak vikasit karnyat aala. seudomonas putida dii. ess. emm. 50026 peshi jaivik ghatak mhanoon vaparlya gelya aanee mapan heey vidyutarasayanik mojamapavarun andajit kelelya peshinchya shwasan kriyakalapanvar aadharit hote. redox ausmiyam polymerchya madhyamatoon carbon nanotube (see. aine. tii.) sudharit carbon pest electrodavar (see. pii. eae.) peshi sthir kelya gelya. ausmiyam polymerne peshinchya peshi bhintimadhye asalelya redox enzymes darmyan electron karyakshamatene firavale aanee electrodechya prushthbhagavar sthir bandhan vadhavale. sanvedkatil ishtatam rachana shodhanyasathi, glukojchya pratisadavar see. aine. tii. aanee ausmiyam polymerchya pramanatil badalancha parinam tapasala gela. ph aanee tapmanache parinam dekhil tapasale gele. optimization abhyasanantar, glukojcha thurr mhanoon vapar karoon pranaliche vaishishtya darshavile gele. shivay, sukshmajiv jaivasanvedak dekhil phenolshee julavun ghetalelya jivanuncha vapar karoon tayar kele gele aanee nantar, finolmadhye calibrate kele gele. tyanantar, krutrim sandpanyachya namunyat phenol shodhanyasathi tyacha vapar karnyat aala. abhyasat asey aadhalun aale qee sampoorn peshi pii. oes-redox polymer aanee jivanu peshinmadhil vegwan electron sankalan karyakshamatemule, uchch sanvedanshilatesaha oxygenchya anupasthitit glucose tasech zenobiotics sarkhya vividh tharanchya vishleshanasathi oes-redox polymercha vapar karnare putida biosensor heey changle paryay asoo shakatat. see. aine. tii. chya ishtatam pramananchya vaparamule aanee oes redox madhyasthane biosensorchya sanrachanet electron hastantaranala protsahan deuun adhik changli sensor sanvedansheelata pradan kelee. mukhya tote mhanje see. aine. tii. chey uchch prushthbhagache kshetrafal jyamule parshvabhoomi pravahat vaadh jhaali aanee chitrapatatil jawalchya antarachya see. aine. tii. varr tayar jhalelya prasar tharanchya ativyapikaranamule udbhavalelya electronchya prasaran samasya. tathapi, see. aine. tii. aanee polymerchya pramanat sudharana karoon yaa samasyanvar maat kelee jaau shakate.
vishaktateche prashna.
karyatmak see. aine. tii. chee cytotoxity.
sanshodhan asey darshavite qee karyatmak carbon nanotubes heey gair-cytotoxic asatat aanee prathamik rogpratikarak peshinchi karyakshamta rakhoon thevatat. anukrame 1,3-dvidhruvi cycloloadtion pratikriya (eff-cnts 1 aanee 2) aanee auxidation/amidation upchar (eff-cnts 3 aanee 4) nantar done prakarche eff-cnt tayar kele gele. donhi prakarche eff-see. aine. tii. heey bii aanee tii lymphocytes tasech macrophages inn vitrodvare ghetale gele, jyamule peshinchya vyavharyatevar parinam jhaala nahee. tyanantar, vegvegalya peshinchya karyakshamateche kaljipurvak vishleshan kele gele. heey aadhalun aale qee eff-see. aine. tii. 1, jeey panyat atyant virghalanare aahe, rogpratikarak peshinchya karyatmak kriyakalapanvar prabhav padat nahee. eff-see. aine. tii. 3, jyamadhye tyaeivaji vidravyata qamee hote aanee pramukhyane sthir paanee nilamban tayar hote, macrofagesdware proinflammatory cytokineschya srawala uttejan detana lymphocyteschi karyakshamta jatan kelee. yaa abhyasatoon lakshat ghenyasarkhi eka mahattvachi gosht mhanje lipids karya karnare kahee prakarche see. aine. tii. heey panyat vidravya asatat jyamule manvi shariratoon tyanchi halchal sulabh hoil aanee sharirachya mahattvachya avyavanchya marganmadhye adthala yenyachi jokhim dekhil qamee hoil jyamule teey aushadh vitaran vahane mhanoon adhik aakarshak hotil.
inn vitro cytotoxicity.
manvi khagoliy peshi aanee fuffusachya karkarogachya peshinmadhil eka aanee bahu-bhinti asalelya carbon nanotubeschya inn vitro vishaktatechi tapasani karnyat aalee. ekal-bhinti asalelya nanotubes (ess. aine. tii.), bahu-bhinti asalelya nanotubes (emm. aine. tii.) aanee karyatmak emm. doubleu. (emm. doubleu.-kooh aanee emm. doubleu.-aine. etch. 2) yanchya bhautik rasayanik gunadharmanche vaishishtyikaran karnyasathi aanee emm. tii. tii. parikshan aanee calcin/propedium iodide (pii. aay.) daag vaparoon manvi astrocytoma dii. 384-peshi aanee fuffusanchya carcinoma aii. 549-peshitil tyanchya cytotoxicityche moolyankan karnyasathi haah abhyas haatee ghenyat aala. prapt jhalelya aanee sudharit asha donhi nanotubesche vaishishtya pramukhyane karyatmakateche praman tapasanyasathi aushnik vishleshan (tii. jee. aii.), infrared spectroscopy aanee anushakti sukshmadarshakachya madhyamatoon darshavile gele hote. 10 takke eff. see. asalelya madhyamat 24,48 aanee 72 tasansathi peshi nanomaterialschya (0.1-100 microgram/miilii) samparkat aalya. aalya peshinmadhye emm. tii. tii. chya parinamanmadhye, uchch sandratemadhye kinwa dirgh ushmayan velet pudhil badal naan karata, aadhich 0.00 microgram/milliver 24 tasanchya samparkanantar, shengdanyanchi majboot cytotoxicity (50 takke) disun aalee. serve velchya bindunvar emm. tii. tii. chayapachay itar serve sanyuganni 10 microgram/milliver 50 takkyanni qamee kele aanee jaast matret konatihi vaadh jhaali nahee. aii. 549 pesheensah samaan parinam prapt jhaale. calcin/paee daag vaparnyachya prayoganni prayoganni dii384-kinwa emm. tii. tii. cytotoxicity detachi pushti kelee nahee. sakaratmak niyantran ess. aay. oo. 2 vagalata, konatyahi ekagratevar kinwa pradarshanachya velee konatyahi nanotubemule yaa peshinchya vyavharyatevar parinam jhaala nahee. parinamanni rung chinhakansah nanomaterialschya hastakshepamule krutrim parinamanchya sambhavya samasyela talhanyasathi anek chachanyanchya madhyamatoon carbon nanotubechya vishari parinamanchi kaljipurvak tapasani karanyachi aavashyakta suchavali.
shimplay aanee emm. doubleu. see. aine. tii. chee cytotoxicity.
utparivartanala chalana denyachya tyanchya kshamatesathi anek prajatinmadhye bahu-bhinti asalelya carbon nanotubeschi tapasani kelee gelee aahe. palak, under, vividh manvi peshi resha aanee undaranvaril abhyasatoon asey disun aale aahe qee emm. doubleu. see. aine. tii. chya samparkat yene heey oxidative nuksan, vadhalele apoptosis, gunasutra nuksan aanee necrosishi sambandhit aahe. undaranvaril abhyasat asey aadhalun aale aahe qee fuffusachya karkarogasathichya biomarkerswar visheshtah emm. doubleu. see. aine. tii. chya samparkat aalyane parinam jhaala hota; carbon nanotubeschya vyavsayik samparkat yenyavar dekhrekh thevanyachi eka paddhat mhanoon yaa biomarkerswar sanshodhan kele jaat aahe.
ekal-bhint nanotubes (ess. aine. tii.), bahu-bhint nanotubes (10 teey 20 aine. emm., emm. aine. tii. 10 paryant vyas asalelya) aanee fulrin (see. 60) sathee praudh giinii dukrankadun prapt jhalelya nirogi vayuvahak macrophage peshinvar cytotoxicitychi tapasani kelee gelee. vitromadhye 6 tasanchya samparkanantar vayuvahak macrofagemadhye (aii. emm.) shimpadyanchi sakhol cytotoxicity disun aalee. cytotoxicitymadhye ~35% itaki vaadh jhaali jevha shengdanyanche praman 11.30 3.06 neey vadhavale gele. aanee sathee 226.00 3.06 chya matreparyant konatihi lakshaniy vishaktata disun aalee nahee. cytotoxicityne vastuman aadharavar anukramachya kramache anusaran keleh shimplay> shimplay> quartz> aanee. shimplay lakshaniyaritya 0.38 3.06 chya qamee matret emm. emm. chey phagocytosis bighadavale, tarr kinwa aanee aanee neey keval 3.06 3.06 chya uchch matret dukhapat kelee. 3.06 3.06 chya myant kinwa kinwa chya samparkat aalelya macrofagemadhye necrosis aanee degenerationchi vaishishtyapurn vaishishtye darshavili gelee. apoptotic peshinchya mrutyuche lakshan astitvat asanyachi shakyata aahe. abhyasatoon assa nishkarsh kadhanyat aala qee vegvegalya bhaumitik sanrachanansah carbon nanomaterials vitromadhye agadi bhinn cytotoxicity aanee bioactivity darshavtat, jaree teey vivomadhil tulanatmak vishaktatemadhye achookpane pratibimbit kele jaau shakat naheet.

