martin aar. ralf

martin aar. ralf heey eka circadian jivashastradnya aahet jeey torrento vidyapithatil manasshastra vibhagat pradhyapak mhanoon kaam karatat. tyanche sanshodhan pramukhyane majjasanstha, manasshastra aanee antahsravishastra yaa kshetratil circadian laybaddhatevar kendrit aahe. tyache sarvat ullekhaneey kaam supertusematic nucleusver hote, jyala aata sastan pranyanmadhye central circadian pacemaker mhanoon olakhale jaate, parantu tyane vel, smrutee aanee prakashachya sandarbhat circadian talanchi dekhil tapasani kelee aahe.
prarambhik shikshan.
martin ralf yanni 1972 teey 1976 paryant stanford vidyapithat shikshan ghetale, jithe tyanni jivashastrat padvi midavali. tyanantar 1982 teey 1986 yaa kalat oregon vidyapithat shikat asatana tyanni doctorate midavali. ph. dii. midvalyanantar.dii, teey rahile aanee circadian jivashastradnya dow. virginia vidyapithatil michael menekar, jithe tyane suvarn hamstermadhil taau utparivartan shodhanyat sarvat ullekhaneey madat kelee. 1998 madhye teey torrento vidyapithat manasshastrache pradhyapak mhanoon ruju jhaale.
vaidnyanik yogdan.
taau utparivarti hamstercha shodh aanee anuvanshik aadhar.
padvi vidyarthi mhanoon kaam karat asatana dow. circadian jivashastrachya aadhunik aajobanpaiki eka asalelya michael menekarne eka soneri hamster shodhala jyacha masik palicha kalavadhi 24 tasanpeksha qamee hota. golden hamsterchya motor kriyakalapanchya talanmadhye samanyatah 24 tasancha kalavadhi asato, jyat thoda farak asato. yaa utparivarti hamsterche aanakhi prajnan kelyanantar, tyachya lakshat aale qee samayugma utparivartanancha dainandin kriyakalapancha kalavadhi 20 tasancha asato aanee vishamyugma utparivartakancha kalavadhi 22 tasancha asato. circadian jivashastrat, taau (τ), jivanmadhil taal kalavadhi darshavite, mhanoon circadian talala 24 tasanchya jawal taau moolya asate. kalavadhitil farak lakshat gheta, tyane yaa utparivartit prabhedala 'taau hamster' asey naav denyache tharavale.haah hamster haah sastan pranyanmadhil circadian layasathi anuvanshik aadharacha pahila purava hota aanee shariracha aakar aanee melatonin abhivyakti yasarkhya halchalinvyatirikt circadian laybaddhatecha anuvanshik aadhar aanee vishisht prathine aanee vartananmadhil laybaddhatecha adhik abhyas karnyasathi eka model mhanoon vaparla gela aahe.
nantar tyanni dow. keey. keey. keey. yanchya netrutvakhalil circadian jivshastradnyanchya chamusobat kaam kele. taau utparivarti hamsterchya 20 tasanchya kalavadhisathi jababdar asalelya utparivartanache sthan olakhanyasathi joseph takahashi. utparivarti aanee jangali prakarchya hamstermadheel anuvanshik farak olakhanyasathi tyanni anuvanshikdrushtya nirdeshit pratinidhitvatmak farak vishleshan (jee. dii. aar. dii. aii.) vaparale, jeey anuvanshik utparivartananna vishisht vaishishtyashi jodanyasathi vaparale jaanare eka parikshan aahe. tyanni cassiin kinness 1 epsilon (see. keey. 1. eae.) januk encoding pradarshit pradeshatil gunasutra 22 madhye anuvanshik farkanche kshetra sthanik kele. tyanni dakhavun dile qee see. keey. 1. eae. haah masik paalee janukashi sanvad sadhato, joou sastan pranyanchya circadian januk mhanoon sthapit keela gela aahe aanee see. keey. 1. eae. chya utparivarti aavruttit hii kriya qamee jhaali, jee taau utparivarti hamsterchya vartanache spashtikaran sadar karate.
circadian pacemaker mhanoon suprachiasmatic kendrakachi olakh.
utparivartit (taau) soneri hamstercha pahila vapar mhanje suprachiasmatic nucleus (ess. see. aine.) laa dainandin layatil eka mahattvacha vegwan vegwan yantra mhanoon olakhane. jevha ess. see. aine. jangali prakarchya hamstermadhye virghalale gele, tevha tyanchi laybaddh halchalinchi kriya qamee jhaali. tyanantar tyanni daata hamstermadhun eka naveen ess. see. aine. pratyaropit kele aanee daata hamsterchya kalavadhipramanech prapt pradarshit hamstermadhye punarsanchayit layasheelata pahili. jarr daata jangali prakarcha asel tarr tyanni 24 tasancha kalavadhi pahila aanee jarr daata samaroop utparivartak asel tarr tyanni 20 tasancha kalavadhi pahila. yaa prayogane yaa hamstersmadhye dainandin zope-jaage honyacha taal tayar karnyasathi ess. see. aine. chee aavashyakta aanee pureshita donhi siddha kelee. circadian sanshodhakanni ess. see. aine. chaa abhyas suru thewala aanee hii rachana aata sastan pranyanmadhye prathamik circadian pacemaker mhanoon olakhali jaate.
prakashadvare maskingcha prabhav nirdharit karane.
kahee dow. ralfchya sarvadhik uddhrut kelelya karyat tyachya yogdanacha samavesh aahe jyat prakashane masking darshavile aahe. masking mhanje prakashasarkhya bahya sanketanchi kshamata jee circadian talat ektrit karoon pranyanchya vartanavar prabhav takoo shakate. pranyache tyache janmajat jaivik ghadyal chaloo asalyane, itar bahya sanket ghatak aahet jyamule prani paryavaraniy badalanna lagech pratisad deu shakato. udaharanarth, ekhadya pranyachya dainandin vishrantichya tappyat prakashachi naadee asanyane, agadi alpakalasathi, jaree tyaa lahan uttejananantarhi, masik paalee aanee laybaddhatet badal houu shakato.
tyanchyabarobar kelelya kamat dow. menekar prayogshaletil garry picard, dow. ralfaney undarancha abhyas keela, jyanche aantarjanukiy patrak (aay. jee. ell.), prakash samajoon ghenyasathi mahattvacha drushtipatal marg, shastrakriyedvare kadhoon takale gele hote.
ekandarit, tyanna aadhalale qee jakhaminchya undaranni tappyatil vilamb vadhavala hota aanee halakya spandananmule tappyatil badalanna qamee pratisad dett hote. yavyatirikt, satat prakashat rahnyachya sthiteet undarancha sakriy kalavadhi dirghkal tikala nahee. yaa aakadevarine asey suchavale qee ii. jee. ell. neey kadachit prakash mahitee suprachiasmatic kendrakala parat denyat mothee bhoomika bajavali. nantar golden hamsters kelelya prayoganni yaa parinamanmadhye bharr ghatali aanee suchavale qee circadian pratisad haah jyaa "paryavaraniy paristhiti" varr prakash deela jaato tyavar avalambun asato.
prakash-aadharit pratisadanvar gaba niyaman.
menekar prayogshalet kaam kartana, ralfane prakashala circadian pratisadanchya gaba niyantranachi dekhil tapasani kelee. tyanna aadhalale qee gaba virodhi bicuculine tappyatil vilamb rokhate aanee benzodiazepine diazepam (gaba kriyakalapancha eka samarthyavardhak) prakashachya samparkat aalelya soneri hamsterschya tappyatil pragati rokhate. gaba kriyakalapanchya sakriyakartyandvare tappyatil vilambasathi bicuculine-prerit nakabandi qamee kelee gelee, tarr gabachya spardhatmak aanee bigger spardhatmak virodhakanni tappyatil pragatisathi diazepam-prerit nakabandi qamee kelee jaau shakate. yaa nishkarshanvarun asey soochit hote qee gaba-benzodiazepine receptor-ionophore complexes heey yaa aushadhanchya circadian badalansathi krutiche thikan asanyachi shakyata aahe. manoranjak baab mhanje, tyanna aadhalale qee itar gaba agonist aanee virodhi yanni tappyatil pragati aanee tappyatil vilamb yansarkhe avarodhan nirman kele nahee, jeey anukrame diazepam aanee bicuculine yanni kele, jyamule chloride chalakatavadatil badalanvyatirikt paryayi yantrana suchavali.
shikanyavar aanee smaranshaktivar circadian parinam.
aanakhi eka kshetra dow. ralfche sanshodhan circadian talamule shikshanavar vyatyayamule prabhavavar aahe. undaranvar kaam kartana, dow. ralf aanee itar sanshodhakanna asey aadhalale qee ekhadya mahattvachya ghatanechi vel pravesh karnyayogya ausilatordware encode kelee jaate jee ghatanechya velee dopamine sankramanatil tivra badaladvare seet kelee jaate, jyamule pranyanna divasatil vel shikata yete aanee lakshat thevanyas madat hote qee lakshaniy paristhiti udbhavate aanee 24 tasanchya antarane punaravrutti apekshit hote. dow. ralfala asehi aadhalale aahe qee hamstermadhil conditioned places avoidancechya circadian modulationsathi ess. see. aine. (suprachiasmatic nucleus) chee aavashyakta nasate, jeey soochit karate qee divasachya velesathi smrutisathi ess. see. aine. pasoon vegalya circadian ausilatorchi aavashyakta asoo shakate.
dirghayushyavar circadian prabhav.
martinchya sanshodhanache aanakhi eka kshetra dirghayushyavar circadian talatil vyatyayamule vyatyayamule prabhavavar kendrit aahe. circadian talanchi karyatmak bhoomika changlya prakare sthapit jhaali asali taree, sharirvidnyanatil dainandin dolananchya anukulatebaddal aanee jivanmadhil vartanabaddal phaar qamee mahitee hotee. tyala aadhalale qee jangali aanee samarupata asalelya taau utparivarti hamsterschya tulanet taau utparivarti hamsterney ayurman lakshaniyaritya qamee kele aahe. garbhachya menduchya kalamanche ess. see. aine. neey pratyaropan kelyane naisargikaritya vayabarobar sambandhit vartanukichya laybaddhatet ghat jhaali aanee praudh hamstermadhye 20 takkyanni dirghayushya vadhale. kharey tarr, ess. see. aine. kalam prapt kelelya 11 hamsters serve niyantrananpaiki 50 takke peksha jaast kaal tikoon rahile, menduchya itar uutinchya prakaranchya kalam tayar kelyane niyantrananpramanech ayurman hote. heey nishkarsh asey suchavatat qee ghadyalacha veg vayanusar qamee hoto aanee vartanukitil qamee taal (dhavanyachi vel mhanoon mojale jaate) kahee aathvadyant aayurmanacha atyant andaj lavtat.
itar majjatantu pratyaropan prayog.
ralfchya ess. see. aine. pratyaropan abhyasat keval ess. see. aine. chee bhoomika darshavili gelee nahee, tarr tyat haravalele karya punarsanchayit karnyasathi majjatantu pratyaropanachi kshamata dekhil darshavili gelee. neurodegenerative roganvar upchar mhanoon yach prakriyecha shodh ghetala jaat aahe. 2020 madhye jhalelya abhyasat, prerit-pluripotent stame peshinmadhun karyatmak uutinche pratyaropan parkinson rogane grast asalelya rugnache karya punarsanchayit karoo shakate qaa yacha shodh ghenyat aala. kalam yashasviritya tikoon asalyachi pushti kelyanantar, tyanna aadhalale qee done varshanchya kalavadhit rugnachi lakshane sudharali kinwa sthir rahili. heey keval eka rugnavar kele gele heey ullekhaneey aahe. neural transplant abhyasachya alikadil meta-vishleshanane (2022) asey darshavile aahe qee dopamine-utpadak peshinna stame-selpasoon vyutpann samatulya vaparoon badalane keval rugnansathi surakshit nahee tarr motor karya aanee dainandin jeevan kshamata sudharu shakate. asach aanakhi eka abhyas dow. ralfchya karyat 2014 madhye kelelya kamacha samavesh aahe jyamadhye asey disun aale aahe qee interneuronschya pratyaropanamule alzheimer rogachya maus modelmadhye visheshtah smaranshakti aanee sandnyanatmak karya punarsanchayit hote, avarodhak interneuronsche pratyaropan uttejak neurons parasparsanvadvare samanya karya nirman karnyat adthala aananyachya bhoomikevar prakash takte.
sadhyache kaam.
ralfane toronto vidyapithat, visheshtah under aanee hamsterschya lahan sastan pranyanchya namunyanmadhye, circadian sanshodhanat aapali ruchi kayam thewali. tyachi prayogshala circadian ly niyantrit aanee pradarshit pradarshit prathinanchya vartanachi aanee zeetgebar aanee prathin utparivartan donhi tyanchya abhivyaktivar aanee pranyanchya vartanavar kassa parinam karatat yachee tapasani karate. tyanni yaa vishayancha pramukhyane majjasanstha aanee manasshastra yaa kshetranmadhye abhyas keela aahe. agadi alikade, tyanchya prayogshalene ekoon circadian ghadyalapasun swatantra vishisht smrutee karyansathi circadian prathine kashee niyantrit kelee jaatat yacha abhyas keela. tyanni asey nirikshan kele qee antarnihit vel-smrutee, eka vishisht velechi achetan smrutee jee apekshit kelee jaau shakate jyaa darmyan eka mahattvapoorn ghatana varanvar ghadate, keval menduchya pattyamadhye aanee ekoon circadian ghadyalavar parinam naan karata 'prati 2' emm. aar. aine. aii. abhivyaktiche niyaman karate. heey sanshodhan mendumadhye sharirikdrushtya velechi smrutee kuthe aahe yaa prashnache uttar denyas suruvat karnyasathi purave pradan karate, jeey sadhya adnyat aahe.
sanman aanee puraskar.
1988 pasoon jaivik talanvaril sanshodhanasathi societycha sadasya.
aaa.pii. aktoobar 1991 madhye sloan foundation sanshodhan shishyavrutti
2013 pasoon kalanukramik jivshastrasathichya canadian societycha sadasya.
2011 pasoon european jaivik ly societyche mandalache sadasya

