parasparsanvad

superoxide dismutase [kyu-zdn] jyala superoxide dismutase 1 kinwa etch. ess. oo. dii. 1 asehi mhanatat, heey eka enzyme aahe jeey manavanmadhye gunasutra 21 varr sthit "sooad 1" janukadware encode kele jaate. sooad 1 heey teen manvi superoxide dismutacespacky eka aahe. heey apoptosis, familial amyotrophic lateral sclerosis aanee parkinson rogat guntalele aahe.
rachana.
rachana haah 32 keey. dii. aii. samarupak aahe joou beeta baryl (β-baryl) tayar karato aanee tyat pratyek upaghatakat eka intramolecular diasulphide bandh aanee eka bionuclear kyu/zdn site asate. yaa kyu/zdn sitewar tambe aanee zink aayan asate aanee hydrogen peroxide aanee dioxygenmadhye superoxidechya asamanateche utprerak bananyasathi jababdar aahe. yaa prathinanchi paripakvata prakriya guntaguntichi aahe aanee purnapane samajaleli nahee, jyat tambe aanee zink aayanche nivadak bandhan, see. aay. ess.-57 aanee see. aay. ess.-156 darmyan intra-subunit diasulphide bandh tayar hone aanee done subunitche dimerisation yancha samavesh aahe. parasparsanvad (see. see.) sathiche copper chepron copper incersion aanee diasulphide auxidation sulabh karate. jaree saud 1 chey cytosolmadhye sanshleshan kele gele asale aanee teey tethe paripakv houu shakate, taree mitochondriala lakshya kelelya vyakt kelelya aanee ajunahi aparipakv asalelya saud 1 chaa ansh aantar puttle jaaget ghalane aavashyak aahe. tethe, teey dhatukaran nasale taree, tyachya paripakvata sathee aavashyak asalele diasulphide bandh tayar karate. paripakv prathine atyant sthir asatat, parantu jevha tee dhatumukt aanee diasulphide-qamee swarupat asatat tevha asthir asatat. heey inn vitromadhye disun yete, kaaran dhatuchya aayanchya hanimule parasparsanvad ektrikaranat vaadh hote aanee rog modelmadhye, jethe adravya parasparsanvad sathee qamee dhatukaran disun yete. shivay, prushthbhag-ughad qamee jhalelya cysteine diasulphide crosslingmadhye sahbhagi houu shakatat aanee asha prakare, ektrikaran.
karya.
parasparsanvad tambe aanee zink aayan bandhate aanee shariratil mukt superoxide muldravyancha naash karnyas jababdar asalelya teen superoxide dismutacespacky eka aahe. encoded isozyme heey eka vidravya cytoplasmic aanee mitochondrial intermembrain space protein aahe, jeey naisargikaritya udbhavnare, parantu hanikarak, superoxide radicals aanvik auxigen aanee hydrogen peroxidemadhye rupantarit karnyasathi homodimer mhanoon karya karate. tyanantar hydrogen peroxideche ketales navachya dusarya enzymedware vighatan kele jaau shakate.
bahya mitochondrial patalat (oo. emm. emm.), jethe superoxide aayan tayar kele jaatil kinwa entermembrain spacemadhye sthanikikaran karnyasathi saud 1 gruheet dharale gele aahe. tyachya sthanikikaranasathichi achook yantrana adyap adnyat aahe, parantu oo. emm. emm. shhee tyache ektrikaran heey bii. see. ell.-2. wildtype saud 1. neey majjatantu sanvardhanamadhye antiapoptotic gunadharm darshavile aahet, tarr utparivarti saud 1 heey pathichya kanyachya mitochondriamadhye apoptosisla protsahan denyasathi disun aale aahe, parantu yakrut mitochondriamadhye nahee, jaree teey donhimadhye samanpane vyakt kele gele aahe. done models suchavatat qee bii. see. ell.-2 prathine kinwa mitochondriashich sanvad sadhun parasparsanvad apoptosis rokhate.
vaidyakeey mahatva.
oxidative tanavamadhye bhoomika.
sarvat ullekhaneey mhanje, ischemia-referfusion dukhapatimule oxidative tanadarmyan, visheshtah hrudayavikaracha bhag mhanoon myocardiummadhye (ischemic hridayrog mhanoon dekhil olakhale jaate) pratikriyashil auxigen prajati (aar. oo. ess.) sodanyat saud 1 mahattvapoorn aahe. eka pramukh coronary dhamani bund jhalyamule honara ischemic hriday rog, sadhya pashchatya samajatil rugnata aanee mrutyuche pramukh kaaran aahe. ischemia referfusion darmyan, roseche prakashan peshinvar thet parinam karoon tasech apoptotic sanketandware peshinche nuksan aanee mrutyu honyas lakshaniy yogdan dete. parasparsanvad madhye roseche hanikarak parinam maryadit karanyachi kshamata asalyache dnyat aahe. tyamule, parasparsanvad tyachya hriday-sanrakshanatmak prabhavansathi mahatvache aahe. yavyatirikt, hrudayachya ischemic purvaniyojanedarmyan, ischemia-referfusion dukhapatipasun cardioprotectionmadhye saud 1 samavisht kele gele aahe. jaree rosechya mothya sphotamule peshinche nuksan hote asey olakhale jaat asale taree, ischemiachya pranghatak nasalelya chhotya prakarananmadhye prakarananmadhye mitochondriamadhun roseche madhyam prakashan, ischemic purvaniyojanachya signal transduction marganmadhye mahattvapoorn trigger bhoomika bajavu shakate jyamule peshinche nuksan qamee hote. heey dekhil disun aale aahe qee rosechya yaa muktatedarmyan, saud 1 hyayoge apoptotic signalling aanee peshi mrutyu niyantrit karnyat mahattvachi bhoomika bajavate.
eka abhyasat, keratokonasachya done kautumbik prakarananmadhye janukatil vilopan nondavale gele. saud saud kamatarata asalelya undaranni vay-sambandhit snayu dravyaman qamee karane (sarcopania), motibinducha lavkar vikas, mccular degeneration, thymic involution, hepatocellular carcinoma aanee ayurman qamee kele aahe. sanshodhan asey suchavate qee dirghakalin dant mishran bharane asalelya mahilanmadhye dirghakalin judd dhatuchya visharipanasathi saud 1 patali vadhane heey biomarker asoo shakate.
amyotrophic lateral sclerosis (lau gehrigcha rog).
yaa janukatil utparivartan (aajparyant olakhalya gelelya 150 hoon adhik) kautumbik amyotrophic lateral sclerosishi jodalele aahet. tathapi, anek purave asehi darshavtat qee cellular tanavachya paristhitit, jangali-prakarche saud 1, turalak prakarananchya lakshaniy anshat guntalele aahe, jeey itar rugnanpaiki 90 takke lokanche pratinidhitva karatat.
aahe (yuu madhye) heey sarvat varanvar honare utparivartan aahe.ess.aaa.) aanee aanee (japan). icelandmadhye keval saud saud sapadale aahet. sarvat jaast abhyasalele als maus model mhanje qee. yaa janukasathi durmil pratilekhan prakar nondavale gele aahet.
jawaljawal serve dnyat itar karananmule honare parasparsanvad utparivartan prabhavi paddhatine karya karatat; parasparsanvad janukachi ekach utparivartit prat rogas karanibhoot honyasathi pureshi aahe. jyachyadvare parasparsanvad utparivartananmule rog hoto tee achook aanvik yantrana (kinwa yantrana) adnyat aahe. heey kahee pramanat vishari karya asalyache disate, kaaran anek rog-sambandhit parasparsanvad utparivartak utparivartak aanee aanee utsechak kriyakalap rakhoon thevatat aanee parasparsanvad nockout undaranmadhye als vikasit hott nahee (jaree teey vay-avalambun majboot durastha motor neuropathy darshavitat).
aii. ell. ess. haah eka neurodegenerative rog aahe jyache vaishishtya mhanje motor neuronschee nivadak haanee jyamule snayu ksheen hotat. dii. aine. aii. auxidation utpadan 8-oo. etch. dii. jee. heey oxidative dii. aine. aii. haniche susthapit chinhak aahe. 8-oo. etch. dii. jee. heey als asalelya vyaktinchya pathichya kanyachya motor neuronschya mitochondriamadhye jamaa hote. utparivarti parasparsanvad januk asalelya transgenic alsmadhye, 8-oo. etch. dii. jee. dekhil pathichya kanyanchya motor neuronschya mitochondrial dnmadhe jamaa hote. heey nishkarsh asey suchavatat qee badalalelya saud 1 mule motor neuronschya mitochondrial dnala honare oxidative nuksan haah alsachya etiologymadhye mahattvapoorn ghatak asoo shakato.
aahe utparivartan.
aahe (coden 4 madheel allenine heey valinemadhye badalale gele) heey yuu madheel sarvat samanya aanee itar karanansathi honare utparivartan aahe.ess. loksankhya, sumare 50 takke saud-1-aii. ell. rugna aahe utparivartan vahoon nett aahet. ekoon yoochya andaje 10 takke.ess. kautumbik prakarane hii parasparsanvad madheel vishamjaivik aahe utparivartananmule hotat. utparivartan jarr kadhee americebaher aadhalale tarr kvachitach aadhalate.
alikadacha andaj aahe qee aahe utparivartan 540 pidhyanpurvi (~ 12,000 varshanpurvi) jhaale. utparivartanachya aaspaschya haplotypeveroon asey soochit hote qee aahe utparivartan mool americananchya ashiyai purvajanmadhye udbhavale, jeey berring samudradhunitun americet pohochale.
aahe utparivartak doubluty-sarkhya utparivartakanshi sambandhit aahe. aahe utparivartan asalele rugna suruvatiche badalatya vayache, parantu eksamanpane atishay jalad rogacha abhyaskram darshavtat, jyat 1.4 varshanchya suruvatinantar sarasari jagane (itar pramukh parasparsanvad utparivartanansaha 3 teey 5 varshanchya viruddha, aanee kahee prakarananmadhye jase qee aanee, lakshaniyaritya jaast). heey astitva heey gair-utparivartak parasparsanvadashii jodalelya itaranpeksha barech qamee aahe.
aanee utparivartan.
aanee (coden 46 madheel hystidineche aarjininmadhye rupantar) heey japani loksankhyetil sarvat samanya aanee itar karanansathi honare utparivartan aahe, jyat sumare 40 takke japani saud-1-al rugna heey utparivartan karatat. karatat etch46aarmule chya sakriy thikani tambyachya bandhanachi mothee haanee hote aanee tyamule aanee heey utsechakiyadrushtya nishkriy asate. yaa utparivartanacha rogacha kalavadhi atyant lamb asato, suruvatipasun mrutyuparyantcha tharavik kalavadhi 15 varshanpeksha jaast asato. yaa utparivartanasaha undaranche model qee aanee aanee als undaranmadhye disanari shastriy mitochondrial vaculation pathology pradarshit karat naheet aanee qee undaranpramane, pramukh mitochondrial antioxidant enzyme, enzyme chya kamtaratecha tyanchya rogachya prakriyevar konatahi parinam hott nahee.
qee utparivartan.
qee (glycine 93 chey aleninmadhye rupantar) heey tulanene durmil utparivartan aahe, parantu undaranmadhye model kelele heey pahile utparivartan asalyane tyacha atishay sakhol abhyas keela gela aahe. qee heey eka chhadm-doubluty utparivartan aahe jeey enzyme kriyakalap akhand sodate. jackson prayogshaletun qee under tayar upalabdh asalyamule, yaa modelmadhye sambhavya aushadh uddishte aanee vishari yantraneche anek abhyas kele gele aahet. kiman eka khajgi sanshodhan sanstha (ells therapy development institute) yaa maus modelmadhye mothya pramanat aushadhanchi padade chalvat aahe. nishkarsh qeesathee vishisht aahet qee serve itar karananmule karananmule parasparsanvad utparivartanansathi lagoo hotat heey sadhya adnyat aahe. assa yuktivad keela gela aahe qee qee undaranchi kahee rogshastriy vaishishtye atiprabhavachya kalakrutinmule aahet, visheshtah mitochondrial vaculationshy sambandhit (samanyatah jackson prayogshaletun vaparlya jaanarya qee undaramadhye manvi parasparsanvad janukanchya 20 pratee asatat). kiman eka abhyasat asey aadhalun aale aahe qee pathologychi kahee vaishishtye qeesathee adviteey aahet aanee itar serve utparivartanansathi bahyapravartaniy naheet. pudhil abhyasatoon asey disun aale aahe qee qee aanee aanee modelsche rogjanan spashtapane vegale aahe; kahee aushadhe aanee anuvanshik hastakshep jeey eka modelmadhye atyant fayadeshir/hanikarak aahet, tyancha tyancha modelmadhye ektar vipareet kinwa konatahi parinam hott nahee.
daun syndrome.
daun syndrome (dii. ess.) haah gunasutra 21 chya tippat honyamule hoto. dii. ess.-sambandhit vikrutinmadhye oxidative taana haah eka mahattvacha antarnihit ghatak manla jaato. gunasutra 21 madhye asalelya parasparsanvad janukanchya tippat aanee vadhiv abhivyaktimule oxidative taana asalyache disun yete. parasparsanvad chya vadhiv abhivyaktimule hydrogen peroxideche utpadan vadhate jyamule cellular dukhapat vadhate.
lalemadhye mojalya gelelya dii. ess. asalelya vyaktinchya dii. aine. aii. madheel 8-oo. etch. dii. jee. chee patali niyantran gatanpeksha lakshaniyaritya jaast asalyache aadhalun aale. niyantrananchya tulanet dii. ess. asalelya vyaktinchya leukocytesmadhye 8-oo. etch. dii. jee. patali dekhil vadhavanyat aalee. heey nishkarsh asey suchavatat qee oxidative dii. aine. aii. chey nuksan dii. ess. chya kahee vaidyakeey vaishishtyanparyant pohochavu shakate.
parasparsanvad.
parasparsanvad see. see. aanee bii. see. ell.-2 shhee parasparsanvad sadhat asalyache disun aale aahe.

