celecyclib

celecyclib (roscovitin kinwa kinwa heey pharmacological cycline-dependent keynage (see. dii. keey.) inhibitorschya kutumbatil eka prayogik aushadh umedvar aahe jeey see. dii. keey. 2, see. dii. keey. 7 aanee see. dii. keey. 9 yasah anek enzyme lakshyanna pradhanyane pratibandhit karate, jeey upcharit peshinchya peshi chakratil vadhicha tappa kinwa sthitee badaltat. celecyclib heey cyclesseldware vikasit kele jaat aahe.haah tappa dusra aahe, doses shreni, bahu-kendra, yadruchchik, duheri-andh, placebo-niyantrit abhyas.
yaa abhyasacha uddesh, 2 cystic fibrosis asalelya, cystic fibrosis asalelya praudh see. eff. vishayanmadhye, 3 divasanchya upchar mukt kalavadhidvare (upchar "bund") vibhakt kelelya, salag 4 divasanchya 4 chakransathi (upchar "chaloo") tondawate dilya dilya roscovitinechya vadhatya matranchya surakshitateche moolyankan karane haah aahe, jyamule kiman eka eff. eff. eff. tii. aar. utparivartanasaha utparivartan hote aanee seudomonas eruginosacha dirghakalin sansarg hoto.
yaa abhyasat 36 cystic fibrosis rugnancha samavesh hotah 24 upcharit aanee 12 niyantrane.
celeciclibche sanshodhan naun-small seela fuffusacha karkarog (aine. ess. see. ell. see.), cushing rog, leukemia, etch. aay. vhee. sansarg, parkinson rog, herpes simplex sansarg, cystic fibrosis aanee dirghakalin daah vikaranchya yantranevar upchar karnyasathi kele jaat aahe.
celecyclib heey 2,6,9-pratisthapit purin analogue aahe. see. dii. keey. 2 saha sankulatil tyachi rachana 1996 madhye nishchit karnyat aalee. celecyclib see. dii. keey. 2/eae, see. dii. keey. 2/aii, see. dii. keey. 7 aanee see. dii. keey. 9 pratibandhit karate.
chikitsalayin chachanya aanee prayogshala chachanya.
karkarogavaril upchar.
celecyclib heey naun-small seela fuffusachya karkarogachya (aine. ess. see. ell. see.) aanee itar karkaroganchya upchar kelelya karkarogachya peshinmadhye apoptosis tayar karate asey aadhalun aale aahe. celecyclibchya yapurvi 240 aine. ess. see. ell. see. rugnanmadhye vidyaman pahilya aanee asamanya-ola upcharansah sanyukt matra mhanoon aay. aay. aii. chya tappyatil vaidyakeey chachanya jhalya aahet. sadhyachya "moolyankan" chachanimadhye, chachanimadhye kramankachya rugnanmadhye aine. ess. see. ell. see. sathee monotherapy mhanoon sanshodhan aushadhachi aay. aay. bii. clinical chachani suru aahe. aine. ess. see. ell. see. sathee celecyclibchya pahilya tappyatil chachanyanmadhye nondavalele dushparinam mhanje "malmal, ulatya, seeram creatinine aanee yakrutachya karyatil mapdandanmadhil kshanik vaadh aanee kshanik hypocalemia".
rogpratikarak vikar.
celecyclib heey bii-seela lymphomachya vaidyakeey chachanyanmadhye dekhil aahe, jyat multiple myeloma dekhil samavisht aahe. celecyclib heey aar. aine. aii. polymerase II-aadharit pratilekhan aanee emm. see. ell. 1 prathinanche daun-regulation rokhate asey disun aale aahe.
neutrophil granulocytesmadhye apoptosis prerit karnyasathi celeciclibla 'inn vitro' darshavile gele aahe. jarr hii yantrana surakshit, vishvasarh aanee karyaksham "inn vivo" asalyache nishpann jhaale, tarr heey aushadh cystic fibrosis aanee sandhivat yasarkhya dirghakalin daah roganvar upchar sudharu shakate. hyanvar sahasa glucocarticoidsdware upchar kele jaatat jyanche anekada gambhir dushparinam hotat.
majjasansthevaril upchar.
majjasansthemadhye, celecyclib heey microglial sakriyan dadapun takte aanee cerebral ischemiachya pranyanchya namunyanmadhye kahee neuroprotection pradan karate asey disun aale aahe. yavyatirikt, heey glioblastoma multiformchya upcharanmadhye temozolomidechi antitumer kriya vadhavate aanee gliomasathi eka sambhavya upcharatmak paryay manale jaate.
vishanuvirodhi prabhav.
celecyclib haah eka sambhavya vishanuvirodhi ghatak dekhil aahe. yamule etch. aay. vhee. neey sankramit jhalelya peshincha mrutyu hoto aanee herpes simplex vishanuchi pratikruti tayar honyapasoon rokhate.
andashay utpadan.
celeciclibmule parthenogenetic undy sakriy hotat asey disun aale aahe. tathapi, teey asamanya asamanya dhruviy vastoo tayar karate aanee tyamule sambhavya enuplied zygots tayar karatat. undy sakriy karnyat samanyatah calcium dolanancha samavesh asato, parantu celecyclibchya babatit asey hott nahee. seciclibmule prathine kinesses pratibandhit karoon undy sakriy hotat jyamule paripakvata protsahan ghatak (emm. pii. eff.) nishkriy hoto.
mootrapind hypertrophy.
5/6 nephrectominantar celecyclib mutrapindachya atisuraksha 45 takkyanni qamee karate.
dushparinam.
yamule gambhir dushparinam hotat jeey dainandin aadharavar sahan kele jaau shakat naheet. dushparinamadhye hypocalemia aanee yakrutachya utsechakanche uchchikaran yancha samavesh hoto. yaa dushparinamanmule celecyclibla yuu. ess. eff. dii. aii. neey manyata dileli nahee.

