karkarogamadhye dii. aine. aii. methylation

karkarogatil dii. aine. aii. methylation vividh bhoomika bajavate, jyamule karkarogachya peshinmadhye januk abhivyaktiche niyaman karoon kinwa roggrast peshinchya rogachya namunyat nirogi peshi badalanyas madat hote. dii. aine. aii. methylation disregulation sarvat vyapakpane abhyas keela jaanara eka mhanje pravartak hypermethylication jethe pravartak pradeshanmadhil see. pii. jee. ess. bete methylated asatat, jyamule januke shant hotat kinwa yogdan detat.
falit andyatoon (zaigot) aalelya serve sastan pranyanchya peshi eka samaan dii. aine. aii. kram samayik karatat (kahee vanshatil naveen utparivartan vagalata). tathapi, vividh uutinchya vikasadarmyan aanee nirmitidarmyan epigenetic ghatak badaltat. badalanmadhye histone badal, see. pii. jee. bett methylation aanee chromatin punarrachana yancha samavesh aahe jyamule vishisht janukanche sthir maun kinwa sakriyakaran houu shakate. ekada bhinn ootee tayar jhalya qee, see. pii. jee. eyeland methylation samanyatah dii. aine. aii. methylation dekhbhal yantradvare eka peshi vibhaganitun heey peshimadhye sthirpane varshane milate.
karkarogamadhye, prathine coding janukanmadhye anek utparivartaniy badal aadhaltat. colorectal karkarogamadhye samanyatah 3 teey 6 chalak utparivartan aanee 33 teey 66 hayachkaykar kinwa pravasi utparivartan asatat jeey prabhavit janukanmadhil prathinanchya abhivyaktila shant karatat. tathapi, karkarogachya pragatimadhye janukanche maun nirman karnyasathi utparivartanapeksha pratilekhan maun adhik mahattvache asoo shakate. colorectal karkarogamadhye see. pii. jee. eyeland methylationdware jawalpas 600 teey 800 januke, jawalpasachya samanya samanya uutinchya tulanet, pratilekhanadware shant kelee jaatat. asha see. pii. jee. bett methylation varnan glioblastoma aanee mesotheliyomadhye dekhil kele gele aahe. karkarogatil pratilekhan dadapshahi itar epigenetic yantranedvare dekhil houu shakate, jase qee micrornachya badalalelya abhivyaktidvare.
see. pii. jee. bete heey varanvar niyantran ghatak aahet.
see. pii. jee. bete samanyatah 200 teey 2000 bases jodya lamb asatat, seeh jee bases jodee samagri 50% peksha jaast asate aanee varanvar 5 '→ 3' see. pii. jee. anukram asatat. janukanchya pratilekhan prarambh sthalajaval asalelya sumare 70 takke manvi pravartakanmadhye see. pii. jee. bett asate.
janukanchya pratilekhan prarambh sthalapasun antaravar asalelya pravartakanmadhye dekhil varanvar see. pii. jee. bete asatat. udaharanarth, dii. aine. aii. durusti januk "aii. aar. see. see. 1" chaa pravartak olakhala gela aanee tyachya coding kshetrachya varchya bajula sumare 5,400 nucleotides aadhalale. microrna aanee lamb naun-coding aar. aine. aii. (ell. aine. see. aar. aine. aii.) sarkhya karyatmak noncoding aar. aine. aii. sathee pravartakanmadhye see. pii. jee. bete varanvar aadhaltat.
pravartakanmadhye see. pii. jee. betanche methylation janukanna sthirpane shant karate.
tyanchya pravartakanchya see. pii. jee. betanvaril see. pii. jee. sthalanchya anek methylationdware januke shant kelee jaau shakatat. jaree janukanche mook karane heey heey yantranedvare suru kele gele asale taree, janukanche mook karane sthir karnyasathi pravartak see. pii. jee. betavaril see. pii. jee. sthalanche methylation barechada kele jaate. dusarikade, pravartakanmadhye see. pii. jee. betanchya hypomethylationmule janukanchya atee-abhivyaktimadhye parinam houu shakato.
karkarogamadhye see. pii. jee. hyper/hypo-methylationla protsahan dene.
karkaroganmadhye, utparivartananpeksha pravartak see. pii. jee. betanchya hypermethilationdware janukanchi abhivyakti qamee hone sumare 10 putt adhik varanvar hote. udaharanarth, collan tumourmadhe, jawalchya samanya samanya colonic shleshmal gathichya tulanet, sumare 600 teey 800 judd methylated see. pii. jee. bete tumourmadhil janukanchya pravartakanmadhye aadhaltat, tarr hii see. pii. jee. bete jawalchya shleshmal gathimadhye methylated nasatat. yaulat, woggelstein aanee itar. lakshat ghya, colorectal karkarogamadhye samanyatah fakt 3 teey 6 chalak utparivartan aanee 33 teey 66 haychaker kinwa pravasi utparivartan asatat.
karkarogamadhye janukanche maun mitavanyasathi dna durusti karate.
turalak karkaroganmadhye, dii. aine. aii. durustichi kamatarata adhunmadhun dii. aine. aii. durusti janukatil utparivartanamule asalyache aadhalun yete. tathapi, karkarogatil dii. aine. aii. durusti janukanchi abhivyakti qamee hone kinwa anupasthit rahane heey tyachya pravartakachya methylationmule barechada hote. udaharanarth, tapasani kelelya 113 colorectal karkaroganpaiki, dii. aine. aii. durusti januk 'emm. jee. emm. tii.' madhye keval charmadhye missense utparivartan jhaale hote, tarr bahusankhyanmadhye 'emm. jee. emm. tii.' pravartak kshetrachya methylationmule 'emm. jee. emm. tii.' abhivyakti qamee jhaali hotee. tyachpramane, dii. aine. aii. durusti januk "pii. emm. ess. 2" abhivyakticha abhav asalelya visangat durusti-kamatarata asalelya colorectal karkarogachya 119 prakarananmadhye, 6 madhye "pii. emm. ess. 2" janukamadhye utparivartan jhaale hote, tarr 103 pii. emm. ess. 2 madhye kamatarata hotee kaaran tyacha jodidar emm. ell. etch. 1 haah pravartak methylationmule dabla gela hota (emm. ell. etch. 1 chya anupasthitit pii. emm. ess. 2 prathine asthir asatat). urvarit 10 prakarananmadhye, pii. emm. ess. 2 abhivyakti gamavane heey microrna, miir-155 chya epigenetic atiprabhavamule asanyachi shakyata hotee, jeey emm. ell. etch. 1 chey niyaman qamee karate.
dii. aine. aii. chya hypermethylisation varanvarta karkarogatil janukanchi durusti karate.
done punaravalokan lekhanmadhye soochibaddha kelyapramane, hypermethylated pravartkansah bavis dii. aine. aii. durusti januke aanee qamee kinwa anupasthit abhivyakti, 17 prakarchya karkaroganmadhye aadhalali. mutrashayacha 93 takke karkarog, potacha 88 takke karkarog, thyroidcha 74 takke karkarog, colorectal karkarog 40%-90% aanee menducha 50 takke karkarog yasah anek karkaroganmadhye 'emm. jee. emm. tii.' chey pravartak hypermethylisation varanvar hote. tyaa punaravalokanat asehi soochit kele gele aahe qee eka kinwa adhik doke aanee manechya karkaroganmadhye, lahan-peshi nasalelya fuffusanchya karkaroganmadhye kinwa lahan-peshi nasalelya fuffusanchya karkarogachya squamous seela carcinomamadhye 33 teey 82 takke varanvartemadhye 'ligg 4', 'niil 1', 'atm', 'emm. ell. etch. 1' kinwa 'fancub' chey pravartak hypermethylisation hote. manvi karkarogatil akali vruddhatva verner syndrome januk epigenetic nishkriyata haah lekh soochit karato qee dii. aine. aii. durusti januk 'doubleu. aar. aine.' madhye eka pravartak aahe joou anek karkaroganmadhye varanvar hypermethylated asato, jyamadhye hypermethylation 11 teey 38 takke colorectal, doke aanee maan, pooat, prostate, stun, thyroid, naun-hodgkin lymphoma, condrosarcoma aanee austiosarcoma karkaroganmadhye hote (doubleu. aar. aine. pahaa).
karkarogatil janukanchya durustisathi dii. aine. aii. chya hypermethylisation sambhavya bhoomika.
jiin aanee robberston yanni tyanchya punaravalokanat charcha kelyapramane, hypermethilationdware dii. aine. aii. durusti janukala shant karane heey karkarogachya pragatiche eka atishay prarambhik paul asoo shakate. asha prakarche maun dii. aine. aii. durusti janukatil jantu-reshechya utparivartanapramanech karya karnyasathi prastavit aahe aanee peshi aanee tyachya vanshajanna karkarog honyachi purvatayari dete. aanakhi eka punaravalokanat karkarogatil dii. aine. aii. durusti janukanchya hypermethylisationsathy prarambhik bhoomika dekhil darshavili gelee. dii. aine. aii. durustisathi aavashyak asalele januk hypermethylated asalyas, parinami dii. aine. aii. durustichi kamatarata bhasalyas, dii. aine. aii. chey nuksan jamaa hoil. dii. aine. aii. chya vadhiv hanimule dii. aine. aii. sanshleshanadarmyan truti vadhatat, jyamule utparivartan hote jyamule karkarog houu shakato.
jarr dii. aine. aii. durusti janukanche hypermethylisation heey carcinogenesischi prarambhik payari asel, tarr teey karkarogachya sabhovatalachya samanya samanya uutinmadhye dekhil houu shakate, jyatoon karkarog udbhavala (kshetra dosh). khaleel takta pahaa.
dii. aine. aii. chey nuksan truti pravan translation sanshleshanadvare utparivartananna janm deu shakate, tarr dii. aine. aii. chey nuksan sadosh dii. aine. aii. durusti prakriyedarmyan epigenetic badalanna dekhil janm deu shakate. dii. aine. aii. durusti janukanchya pravartakanchya hypermethilizationmule jamaa honare dii. aine. aii. nuksan heey karkarogatil anek janukanmadhye janukanmadhye vadhiv epigenetic badalanche srot asoo shakatat.
eka prarambhik abhyasat, transcriptional pravartakancha maryadit sanch pahatana, fernandez aanee itar. 855 prathamik arbudanche dii. aine. aii. methylation profile tapasale. pratyek arbudachya prakarachi tyachya sambandhit samanya uutinshi tulana kartana, 729 see. pii. jee. betanchya thikananmadhye (moolyankan kelelya 1322 see. pii. jee. betanchya thikananpaiki 55 takke) dii. aine. aii. methylationmadhye farak disun aala. yapaiki 496 jaaga hypermethylated (dadapun takaleli) aanee 233 hypomethylated (sakriy) hotya. asha prakare, tumourmadhe pravartak methylation badal uchch staravar hotat. yapaiki kahee badal karkarogachya pragatimadhye yogdan deu shakatat.
karkarogatil micrornache dii. aine. aii. methylation.
sastan pranyanmadhye, microrna (mirna) sumare 60 takke prathine-encoding janukanchya pratilekhan kriyakalapanche niyaman karatat. pratyek mirna, prathine coding janukanchya sarasari 200 sandeshvahak aar. aine. aii. chey pratilekhan lakshya karoo shakatat aanee dadapun takoo shakatat. verba aanee itaranni moolyankan kelelya 167 mirananpaiki sumare eka trutiyansh mirananche pravartak. stanachya karkarogamadhye stanachya samanya uutinmadhye bhinn ritine hyper/hypo-methylated hote. agadi alikadil abhyasat asey nidarshanas aale aahe qee 167 mirananche moolyankan verb aanee itaranni kele. stanachya uutinmadhye vyakt jhalelya mirananpaiki keval 10 takke mirane hote. yaa nantarchya abhyasat asey aadhalun aale qee stanachya uutinmadhil 58 takke mirnanmadhye stanachya karkarogatil tyanchya pravartakanmadhye 278 hypermethylated mirna aanee 802 hypomethylated mirnasah bhinn methylated pradesh hote.
stanachya karkarogamadhye sumare 100 putt jaast vyakt honara eka mirna mhanje miir-182. miir-182 haah bii. aar. see. aii. 1 sandeshvahak aar. aine. aii. laa lakshya karato aanee anek stanachya karkaroganmadhye qamee jhalelya bii. aar. see. aii. 1 prathinanchya abhivyaktiche eka pramukh kaaran asoo shakate (bii. aar. see. aii. 1 dekhil pahaa).
karkarogatil dii. aine. aii. methyltransferase janukanvar niyantran thevanare microrna.
kahee mirna dii. aine. aii. methyltransferase januke "dii. aine. emm. tii. 1", "dii. aine. emm. tii. 3aii" aanee "dii. aine. emm. tii. tii sathee sandeshvahak aar. aine. aii. laa lakshya karatat, jyanche januk utpadan pravartak methylation suru karnyasathi aanee sthir karnyasathi aavashyak aahe. teen punravlokananmadhye saranshit kelyapramane, mirna mirna, miir-29aii aanee aanee lakshya lakshya aanee lakshya dnmt3bii; aanee aanee lakshya lakshya aanee miir-152 aanee miir-301 lakshya lakshya. yavyatirikt, yavyatirikt lakshya lakshya aanee yavyatiriktachaaa pravartak swatach hypermethylated aahe aanee bahutek prostate karkaroganmadhye qamee vyakt hoto. jevha yaa sukshmajivanchi abhivyakti badalali jaate, tevha teey karkarogatil prathine-coding janukanchya pravartakanchya atee/hypo-methylation srot dekhil asoo shakatat.
sandarbh.
ruben aggreglo, * wein-sing cheng, fafarnando setien, * santiago ropero, * jesus espada, * mario eff. frega, * michel heranz, * maria eff. paz, * montserrat sanchez-sespeds, * maria jesus artiga, * david guerrero, ‡ antoney castels, acatatano wonn kobe, * wilheim aii. manvi karkarogatil akali vruddhatva verner syndrome januk bohr, Â aanee manel esteller * Â epigenetic nishkriyata.praa. naa. laal. academy vidnyan yuu. aii. 2006; 103 (23): 8822-8827.

