tivozanib

fotiwada yaa brand navane vikale jaanare tivozanib heey eka aushadh aahe jeey reliapsed kinwa refractory pragat mootrapind peshi carcinoma (aar. see. see.) chya upcharansathi vaparale jaate. haah eka maukhik shakahari receptor tyrosine keynage avarodhak aahe.
sarvat samanya dushparinamadhye thakwa, uchch raktadab, atisar, bhook qamee hone, malmal, dysphonia, hypothyroidism, khokala aanee stomatitis yancha samavesh hoto.
european unionmadhye august 2017 madhye aanee americet march 2021 madhye vaidyakeey vaparasathi tivozanibla manyata denyat aalee.
vaidyakeey vapar.
done kinwa adhik purvichya pranaligat upcharannantar, punaravrutti jhalelya kinwa apavartak pragat mootrapind peshi karkarog (aar. see. see.) asalelya praudhanchya upcharansathi tivozanibcha vapar keela jaato.
matbhed.
tivozanib centshee jodale jaau naye. johns wart, yakrutatil jaree yaa enzymeche prerak (khalee parasparsanvad pahaa). heey garbhadharanedarmyan gheu naye kaaran teey undaranmadhye terratogenic, bhrun vishari aanee bhrun vishari asate.
pratikool parinam.
abhyasatil sarvat samanya dushparinam mhanje uchch raktadab (uchch raktadab, 48 takke rugnanmadhye), dysphonia (ghasa khavkhavane, 27 takke aavaj), thakwa aanee atisar (donhi 26 takke). 1 takke rugnanmadhye uchch raktadab sankat aale.
parasparsanvad.
jaree yaa enzymeche majboot prerak asalelya refampicins tivozanibcha ekach doses dilyane, tivozanibche jaivik ardhayushya aanee ekoon sampark (aii. yuu. see.) ardhyat qamee hoto, parantu raktatil sarvoch sandratevar tyacha konatahi sambandhit prabhav padat nahee. ketoconazole yaa majboot jaree avarodhkasah sanyojan, konatehi sambandhit parinam nahee. yaa nishkarshanche vaidyakeey mahatva dnyat nahee.
aushadhashastra.
krutichi yantrana.
quinoline euria vyutpann, tivozanib heey raktavahinyanchya endothelial vadhichya ghatakachya (vgf) viruddha nivadakpane avarodhak mhanoon angiogenesis dadapate. heey tinhi shakahari receptorsna pratibandhit karnyasathi tayar kele aahe.
pharmacokinetics.
tondane tivozanib ghetalyanantar, 2 teey 24 tasannantar raktatil raktadravyachi patali sarvoch patalivar pohochate. ekoon aii. yuu. see. heey ann sevan karnyapasoon swatantra asate. jevha raktpravahat asato, tevha 99 takkyanhun adhik padarth plazma prathinanshi, pramukhyane albuminshi bandhalele asatat. jaree jaree aanee aanee aanee anek ugt heey enzymes aushadhache chayapachay karnyas saksham asale, taree 90 takkyanhun adhik badal naan jhalelya swarupat prasarit hotat. chayapachay heey demethylation, hydroxylation aanee aine-auxidation utpadane aanee glucoronides aahet.
jaivik ardhayushya 4.5 teey 5.1 divas asate; 79 takke maladware utsarjit kele jaate, bahutekatah aparivartit, aanee 12 takke mutradvare, purnapane aparivartit.
rasayanshastra.
tivozanibcha vapar hydrochloride monohydrate swarupat keela jaato, joou joou teey halakya tapkiri rangachi puud aahe. heey panyat vyavharikdrushtya aghulansheel aahe aanee jaleey aaml, ethanol aanee methanolmadhye qamee vidravyata aahe. heey hygroscopic nahee aanee optikaldrushtya sakriy nahee.
itihas.
yacha shodh kyova kirinane lavala aanee avio pharmaceuticalsne vikasit keela.
clinical chachanya.
rugnanmadhye tappyatil pragat mootrapind peshi karkarogachya parinamanni, sarafenibchya tulanet madhyam pragati-mukt jaganyat 30 takke kinwa 3 mahinyanchi sudharana soochit kelee, parantu prayogik hatacha aanee niyantran hatacha ekoon jaganyacha darr qamee asalyache darshavile. ann aanee aushadh prashasanachya oncologic aushadh sallagar samiteene meey 2013 madhye mutrapindachya peshi karkarogasathi tivozanibchya manjurichya virodhat 13 viruddha 1 mutt dile. yaa samitila vatale qee heey aushadh jokhim-laabh yanche anukool gunottar dakhavanyat ayashasvi tharale aanee chachanichya rachanechya susajjatevar prashnachinh upasthit kele, jyamule niyantran hatachya rugnanna, jyanni serafenibcha vapar keela hota, tyanna pragati roganantar tivozanibmadhye sankraman houu dile, parantu prayogik hatavar asalelya rugnanna trivosanibcha vapar karoon sorafenibmadhye sankraman houu dile nahee. manjurisathi atirikt vaidyakeey abhyasachi aavashyakta asel asey mhanat juuna 2013 madhye eff. dii. aii. neey haah arj aupcharikpane nakarla.
2016 madhye, aii. vhee. oo. oncologyne rugnanmadhye tappyatil chachanimadhye ekoon astitvavar bhaugolik sthan parinam darshavinari mahitee aii. ess. see. oo. baithakichya sanyogane prakashit kelee.
2016 madhye, avio oncologyne rugnanmadhye olichya pragat aar. see. see. rugnanmadhye rugnanmadhye tappyatil clinical abhyas suru karanyachi ghoshana kelee.
2016 madhye, yusa farma aanee avio oncologyne jaheer kele qee kendriyakrut prakriyeantargat punaravalokanasathi european aushadh sansthekade tivozanib sadar karnyat aala aahe.
juuna 2017 madhye, eae. emm. aii. vaidnyanik samiteene europemadhye tivozanibchi manjuri denyachi shifaras kelee, septembermadhye manjuri apekshit aahe.
august 2017 madhye, european aayogane (eae. see.) europemadhil tivozanibla aupcharik manyata dilee.

