
pyruvet dehydrogenase kinez

pyruvet dehydrogenase kinez (pyruvet dehydrogenase complexes kinez, pii. dii. see. kinez kinwa pii. dii. keey.; dekhil) heey eka kinez enzyme aahe jeey pyruvet dehydrogenase enzymela aii. tii. pii. vaparoon phosphorylate karoon nishkriy karnyache kaam karate.
asha prakare pii. dii. keey. pyruvet dehydrogenase complexchya niyamanat sahbhagi hote, jyapaiki pyruvet dehydrogenase haah pahila ghatak aahe. pii. dii. keey. aanee pyruvet dehydrogenase complexes heey donhi eucariotschya mitochondrial matrixmadhye sthit aahet. heey jatil karya payaruvetache (cytosolmadhil glycolysische utpadan) acetyl-koaamadhye rupantar karate, jeey nantar citric acid chakrat urja nirman karnyasathi mitochondriamadhye auxidise kele jaate. yaa sankulachya kriyakalapanche niyaman qamee karoon, pii. dii. keey. mitochondriatil payaruvetache auxidation qamee karel aanee cytosolmadhye payaruvetache lactatemadhye rupantaran vadhvel.
pii. dii. keey. chee viruddha kriya, mhanje pyruvet dehydrogenage defosphorylation aanee sakriyakaran, pyruvet dehydrogenase phosphates navachya phosphoprotein phosphetdware utprerit hote.
phosphorylation thikane.
pii. dii. keey. teen sambhavya thikani pyruvet dehydrogenasever serine avashesh phosphorylate karoo shakate. kahee puravyanvarun asey disun aale aahe qee pahilya thikanavaril phosphorylationmule enzyme jawaljawal purnapane nishkriy hoil, tarr dusya aanee tisya thikanavaril phosphorylation guntaguntichya nishkriyatemadhye keval eka lahan yogdan hote. mhanoon, pyruvet dehydrogenase nishkriyatesathi jababdar asalele 1 vya sthanavaril phosphorylation aahe.
isozymes.
manavanmadhye pii. dii. keey. chey chaar dnyat isozymes aaheth
chaar isozymesmadhil prathamik kramvari 70 takke olakhisah sanrakshit kelee jaate. sarvat motha farak aine-terminsjaval hoto.
pii. dii. keey. 1 heey charpaiki 436 avasheshansah sarvat mothe aahe tarr pii. dii. keey. 2, pii. dii. keey. 3 aanee pii. dii. keey. 4 madhye anukrame 407,406 aanee 411 avashesh aahet. isozymeschi pratyek thikani vegvegali kriyashilata aanee phosphorylation darr asatat. site 1 varr sarvat vegwan teey sarvat mand, pdk2> pdk4 ± pdk1> pdk3. site 2 sathee, pdk3> pdk4> pdk2> pdk1. fakt pdk1 phosphorylate site 3 karoo shakate. tathapi, heey darshavile gele aahe qee yaa kriya piechmadhil kirkol badalanprati sanvedanshil aahet mhanoon pdk isozymesche sookshm vatavaran pratikriya darr badaloo shakate.
isozymechi vipulata dekhil vishisht ootee asalyache disun aale aahe. hriday peshinmadhye pii. dii. keey. 1 bharpur pramanat asate. vrushananmadhye pii. dii. keey. 3 sarvadhik pramanat aadhalate. pii. dii. keey. 2 bahutek uutinmadhye asato parantu pleeha aanee fuffusachya peshinmadhye qamee asato. pii. dii. keey. 4 pramukhyane hadanchya snayunmadhye aanee hrudayachya uutinmadhye aadhalate.
yantrana.
pii. dii. keey. dware phosphorylated kelyavar pyruvet dehydrogenase nishkriy hote. samanyatah, pyruvet dehydrogenage sakriy sthan hydrogen bandhanchya jaalyane samarthit sthir aanee krambaddha sanrachanet asate. tathapi, site 1 varr pii. dii. keey. dware phosphorylationmule phosphorylated avasheshanshi sambandhit vadhalelya aakaramule aanee nakaratmak shulkamule jawalchya dusarya serine avasheshanshi steric sangharsh hoto. yamule hydrogen bandh jaalyat vyatyay yeto aanee done phosphorylation loopchya rachnet bighad hoto. heey loop reductive acetylation stepla pratibandhit karatat, asha prakare enzymechi ekoon kriya thambavtat. 2 aanee 3 yaa thikani phosphorylationsathy sanrachanatmak badal aanee nishkriy karanyachi yantrana sadhya dnyat nahee.
niyam.
pyruvet dehydrogenase keynage haah aii. tii. pii., naadh aanee acetyl-koadware sakriy hoto. heey aii. dii. pii., aine. aii. dii. +, qoo-shh aanee payaruvetdware pratibandhit kele jaate.
pratyek isozyme yaa pratyek ghatkala kinchit vegalya prakare pratisad deto. naadh heey pii. dii. keey. 1 kriyakalapala 20 takkyanni aanee pii. dii. keey. 2 kriyakalapala 30 takkyanni uttejit karate. acetyl-koasah naadh yaa enzymeschi kriyashilata anukrame 200% aanee 300% neey vadhavate. ashach paristhitit, pii. dii. keey. 3 haah nadala pratisad dett nahee aanee naddware acetyl-koasah pratibandhit keela jaato. pii. dii. keey. 4 madhye nadhsah 200% kriyakalap vadhato, parantu acetyl-coa jodalyane kriyakalap aanakhi vadhat nahee.
rogachi prasangikta.
laththapana, madhumeh, hrudayavikaracha zatka aanee karkarogamadhye pii. dii. keey. isophorm vadhatat. kahee abhyasanni asey darshavile aahe qee jyaa peshinmadhye insulincha abhav aahe (kinwa insulinsathi asanvedanshil aahet) tyaa pdk4 jaast vyakt karatat. parinami, glycolysispasoon tayar jhalelya payaruvetache auxidation houu shakat nahee jyamule raktatil glukojcha karyakshamatene vapar keela jaau shakat nahee yaa vastusthitimule hyperglycemia hoto. tyamule, anek aushadhe pii. dii. keey. 4 laa lakshya karatat, jee dusya prakarchya madhumehavar upchar karnyachya aashevar asatat.
etch. aay. eff.-1. pii. dii. keey. 1 chee upasthiti pyruvetla citric acid cyclepasoon door thevate aanee hypoxic peshi jiwant thevate, tyamule hypoxic karkarogachya peshinmadhye pii. dii. keey. 1 chee kriyashilata vadhali aahe. mhanoon, pii. dii. keey. 1 yaa karkarogachya peshinmadhye apoptosisla pratibandh karato mhanoon pii. dii. keey. 1 pratibandh haah eka antitumer upchar mhanoon suchavala gela aahe. tyachpramane, bruhadantra karkarogachya peshinchya reshanmadhye pii. dii. keey. 3 atiprabhavnetun vyakt jhalyache disun aale aahe. teen prastavit avarodhak mhanje aii. zed. dii. 7545 aanee dichloroacetate jeey donhi pii. dii. keey. 1 laa bandhatat aanee radicol jeey pii. dii. keey. 3 laa bandhatat.
pii. dii. keey. 3 janukatil utparivartan heey ex-linked charkot-merrie-tooth rogache (see. emm. tii. ex. 6) eka durmil kaaran aahe.
kutryanmadhye, visheshtah dobberman pincharmadhye, pii. dii. keey. 4 janukatil utparivartan heey dialeted cardiomyopathyshy (dii. see. emm.) sambandhit aahe.