
retooksimab

itaranmadhye retookson yaa brand navane vikale jaanare retooksimab heey eka monoclonal pratipinde aushadh aahe jeey kahee svayampratikar rog aanee karkarogachya prakaranvar upchar karnyasathi vaparale jaate. yacha vapar naun-hodgkin lymphoma, chronic lymphocytic leukemia (gair-geritric rugnanmadhye), sandhivat, polyengitis granulomatosis, idiopathic thrombocytopenic purpura, pemphigus vulgaris, mysthenia gravis aanee epstein-baar vishanu-positive mucocutaneous alsarsathi keela jaato. heey raktavahinyanmadhye haloohaloo injectiondware dile jaate. retuxenchya biosemillermadhye blitzima, riabani, retemvia, rituenza (eff.keey.aaa. tuxella), ricksathon, ruxians aanee truxima.
aushadh dilyanantar done tasanchya aat udbhavananya samanya dushparinamadhye pural, khaaj, qamee raktadab aanee shwas ghenyas tras yancha samavesh hoto. sansarg dekhil samanya aahet.
gambhir dushparinamadhye purvi sankramit jhalelyanmadhye hipatities bii punha sakriy hone, pragatishil multifocal leukoencephalopathy, vishari epidermal necrolysis aanee mrutyu yancha samavesh hoto. garbhadharanedarmyancha vapar vikasansheel garbhasathi kinwa navjat balasathi surakshit aahe qee nahee heey spasht nahee, parantu teey hanikarak siddha jhalele nahee.
retooksimab hii see. dii. 20 prathinanviruddhachi eka chimerick monoclonal pratipind aahe, jee pramukhyane rogpratikarak pranalichya buub peshinchya prushthbhagavar aadhalate. jevha teey yaa prathinala bandhale jaate tevha teey peshinchya mrutyula karanibhoot tharate.
1997 madhye vaidyakeey vaparasathi retooksimabla manyata denyat aalee. tee jaagtik aarogya sanghatanechya aavashyak aushadhanchya yadeet aahe. retooksimabche sanyukt rajyanmadhye biogen aanee genentackdware saha-vipanan kele jaate.ess.canada aanee european unionmadhil hofmann-laa roche, chugai pharmaceuticals, japanmadhil zenyaku kogyo aanee iranmadhil eryogen yanni lihilele.
vaidyakeey vapar.
retooksimab hii see. dii. 20 viruddha lakshyit keleli eka chimerick monoclonal pratipind aahe jee bii peshinvar upasthit asaleli prushthbhagavaril pratijan aahe. tyamule, plazma peshi aanee hematopoetic stame peshi see. dii. 20 prushthbhagavaril pratijan vyakt karat naslyamule tyanna vachavat, teey samanya tasech rogkarak bii peshi qamee karoon karya karate.
united statesmadhye, retooksimab upchar karnyasathi soochit kele jaateh
raktacha karkarog.
retooksimabcha vapar shwet rakt pranalichya karkarogavar upchar karnyasathi keela jaato, jase qee leukemia aanee lymphoma, jyamadhye naun-hodgkins lymphoma, chronic lymphocytic leukemia aanee nodular lymphocyte pramukh hodgkins lymphoma yancha samavesh aahe. yamadhye waldenstromechya macroglobulinemia dekhil samavesh aahe, joou aine. etch. ell. chaa eka prakar aahe. mabthera esasi' aanee 'retookson hayasela' yaa brand navanni vikalya jaananya hyluronidase humanchya sanyogane retooksimabcha vapar follicular lymphoma, mothya bii-seela lymphomacha prasar aanee dirghakalin lymphocytic leukemiachya upcharansathi keela jaato. purvi upchar naan kelelya aanee purvi upchar kelelya see. dii. 20-positive chronic lymphocytic leukemiyavar upchar karnyasathi yacha vapar fluidarabin aanee cyclophosphamide sanyogane keela jaato.
svayampratikar rog.
teen yadruchchik niyantrit chachanyanmadhye retooksimab haah sandhivatacha prabhavi upchar asalyache disun aale aahe aanee aata tyala apavartak sandhivat rogat vaparnyasathi parwana denyat aala aahe. eka kinwa adhik tii. aine. eff.-alfa-virodhi upcharpaddhatila apura pratisad denanya madhyam teey gambhir sakriy sandhivat (aar. aii.) asalelya praudh rugnanmadhye chinhe aanee lakshane qamee karnyasathi methotrexet (emm. tii. ex.) chya sanyogane vaparnyasathi, americet, eff. dii. aii.-manjur karnyat aale aahe. european unionmadhye, parwana thoda adhik pratibandhatmak aaheh gambhir sakriy aar. aii. asalelya rugnanmadhye emm. tii. ex. saha sanyojanat vaparnyasathi parwana aahe jyanna eka kinwa adhik tii. aine. eff. virodhi upcharpaddhatila apura pratisad midala aahe.
itar svayampratikar roganchya shrenimadhye, parinamkarakteche kahee purave aahet, parantu surakshitata aavashyak nahee, aanee multiple sclerosis, systemic lupus erythematosus, dirghakalin dahak demilinating polyneuropathy aanee autoimmune anaemiyachya katheen prakarananvar upchar karnyasathi retooksimabcha mothya pramanat auph-label vapar keela jaato. sarvat dhokadayak, jaree sarvat durmil, dushparinamanpaiki eka mhanje progressive multifocal leukoencephalopathy (pii. emm. ell.) sansarg, joou sahasa pranghatak asato; tathapi svayampratikar roganmadhye udbhavnari prakarane agadi qamee nondavali gelee aahet.
retuximabdware upchar kelelya itar svayampratikar roganmadhye svayampratikar haemolitic raktakshay, shuddha laal peshi applasia, thrombotic thrombocytopenic purpura (tii. tii. pii.), idiopathic thrombocytopenic purpura (aay. tii. pii.), evance syndrome, vasculitis (udaa.jee., polyengitis granulomatosis), bullus tvacha vikar (udaharanarth pemphigus, pemphigoid-2006 chya abhyasanusar pemphigasmadhye andaje 85 takke jalad punarpraptichya atishay utsahavardhak parinamansah), type 1 madhumeh mellitus, sjogren syndrome, anty-aine. emm. dii. aii. receptor encephalitis aanee devic rog, graves ophthalmopathy, autoimmune swadupindashoth, opsoclonus myoclonus syndrome (oo. emm. ess.) aanee aay. jee. jee. 4. sambandhit rog. aayga-madhyasth svayampratikar roganvar upchar karnyat teey aprabhavi aahe yache kahee purave aahet.
pratikool ghatana.
mrutyu aanee apangatvas karanibhoot tharoo shakananya gambhir pratikool ghatananmadhye khaleel goshtincha samavesh hotoh
systemic lupus erythematosus asalelya done rugnancha retooksimabs upchar kelyanantar progressive multifocal leukoencephalopathyne (pii. emm. ell.) mrutyu jhaala. pii. emm. ell. haah mendutil eka samanya vishanu jeey. see. vishanu sakriy jhalyamule hoto, joou samanyatah supt asato. jeey. see. vishanu punha sakriy jhalyas sahasa mrutyu kinwa menduche gambhir nuksan hote.
sandhivat asalelya kiman eka rugnala retooksimabchya upcharanantar pii. emm. ell. vikasit jhaale.
lymphoma asalelya vyaktimadhye dirghakalin hipatities eae sansargamadhye retooksimab haah sambhavya sahghatak mhanoon nondavala gela aahe. hipatities eae sansarg haah samanyatah eka tivra sansarg asato, joou soochit karato qee lymphomachya sanyogane aushadhane vishanula sharirachi rogpratikarak shakti kamkuvat kelee asel.
retooksimabchya satatchya upcharanmadhye eka pramukh chinta mhanje laseela yogya pratisad dene. covid-19 mahamarichya kalat heey laksh vedhanyat aale, jithe multiple sclerosis aanee retooksimab upchar asalelya vyaktinna gambhir covid-19 chaa dhoka jaast hota. multiple sclerosisasathi retooksimab upchar asalelya vyaktinmadhye, tozinameran lasikarananantar 40/microne kinwa tyahoon adhik vikasit sanrakshanatmak patalichya pratipinde asalelya 10 paiki 9 rugnanmadhye.
krutichi yantrana.
pratipind peshi prushthbhagavaril prathine see. dii. 20shhee bandhale jaatat. see. dii. 20 heey buub peshinvar, suruvatichya buub peshinpasoon nantarchya vibhedanaparyant, mothya pramanat vyakt kele jaate, parantu teey antim bhinn plazma peshinvar anupasthit asate. see. dii. 20 chey karya adnyat asale taree, teey plazma patalanvar see. aii. 2 + pravahat bhoomika bajavu shakate, antahkoshik see. aii. 2 + ekagrata rakhu shakate aanee bii peshinna sakriy karoo shakate.
qamee see. dii. 20 peshi-prushthbhag patali asalelya peshinchya nirmulanamadhye retooksimab tulanene aprabhavi aahe. too buub peshinchya eka bajula chikatoon rahato, jithe see. dii. 20 aahe, eka topi tayar karato aanee tyaa bajula prathine odhato. topichya upasthitimule yaa bii peshi nasht karnyasathi naisargik ghatak (enke) peshinchi parinamkarakta badalate. jevha eka aine. keey. peshi topivar chikatate, tevha peshi nasht karnyat tyacha 80 takke yash darr hota. yaulat, jevha bii peshimadhye yaa asamam prathin samoohacha abhav hota, tevha too keval 40 takke vela nasht jhaala.
khaleel parinam aadhalale aaheth
ektrit parinamamule shariratoon buub peshi (karkarogyukt pesheensah) nasht hotat, jyamule lymphoid stame peshinmadhun nirogi buub peshinchi naveen sankhya vikasit hote.
retooksimab see. dii. 20 varr emino acid 170-173 aanee 182-185 laa bandhate, jeey emino acid 167 aanee 183 darmyanchya diasulphide bandhamule sharirikdrushtya ekmekanchya jawal asatat.
itihas.
retooksimab haah aay. dii. see. pharmaceuticalsdware aay. dii. see.-see. 2bii. 8. daad yuu. yaa navane vikasit karnyat aala hota.ess. yaa aushadhache paytant 1998 madhye jaaree karnyat aale aanee 2015 madhye kalbahya jhaale.
vaidyakeey chachanyanmadhil tyachi surakshitata aanee parinamkarakta yanchya aadhare, retooksimabla yuu. neey manyata dilee.ess. 1997 madhye ann aanee aushadh prashasana bii-seela naun-hodgkin lymphomasvar upchar karnyasathi itar chemotherapychya pathyanpasun pratirodhak. retooksimab, kaap chemotherapychya sanyogane, pasarlelya mothya bii-seela lymphoma aanee itar anek bii-seela lymphomachya upcharanmadhye ektyane kapanyapeksha changle aahe. 2010 madhye, follicular lymphomachya prarambhik upcharanantar dekhbhal upcharansathichya european aayogane yala manyata dilee.
jaagtik aarogya sanghatanechya aavashyak aushadhanchya yadeet tyacha samavesh aahe.
2014 madhye, genentackne retooksonche vishesh aushadh mhanoon punarvargikaran kele, aushadhancha eka varg joou keval yuu. ess. madheel vishesh vitarkandware upalabdh aahe. ghauk vikretyanna savalat aanee savalati lagoo naslyamule rugnalaye adhik paise deteel.
moolatah antahshira injectionsathi upalabdh (udaa.jee. 2. 5 tasanpeksha jaast), 2016 madhye, bii-seela see. ell. ell./lymphoma (see. ell. ell.) sathee tvachekhalil injectionchya rachnet tyala eae. yuu. chee manyata midali.
samaj aanee sanskruti.
arthshastra.
februwari 2013 madhye europemadhye aanee september 2016 madhye americet yaa aushadhachya patentchi mudat sampali. america, bharat, european union, switzerland, japan aanee austreliyamadhye anek biosemillerna manjuri denyat aalee hotee. yuu. ess. eff. dii. aii. neey 2018 madhye truxima (retooksimab-abbs), 2019 madhye ruxians (retooksimab-pii. vhee. vhee. aar.) aanee 2020 madhye reabony (retooksimab-arcs) yanna manyata dilee. nantarche darr 500 mii. gra., ghauk, yadinusar sumare $3600 aahe.
sanshodhan.
chronic thakwa syndrome.
2019. 22% madhye prakashit jhalelya chachanimadhye, sahbhaginchya gambhir ghatana jhalelya chronic thakwa lakshansamuchchay asalelya rugnanmadhye retooksimabmule lakshane sudharali naheet. retooksimabs upchar kelelya done karkarog rugnanmadhye chronic thakwa lakshansamuchchayavaril sudharana disun aalyanantar yaa sambhavya vaparachi tapasani karnyat aalee.
intrathecal.
see. aine. ess. rogansathi, retooksimab heey intrathecal paddhatine dile jaau shakate aanee yaa shakyatecha abhyas suru aahe.
itar see. dii. 20 monoclonals.
retooksimabchi parinamkarakta aanee yashamule itar kahee see. dii. 20 monoclonal pratipinde vikasit kelee jaat aaheth