
liim domain

liim domain hii prathinanchi sanrachanatmak domain aahet, jee done sanlagn zink botanni banaleli aahet, jee done-amino acid avashesh hydrophobic linkardware vegali kelee jaatat. domain naav heey teen janukanche sankshipt roop aahe jyamadhye teey pratham olakhale gele hote (lyne-11, isl-1 aanee emm. eae. see.-3). liim heey eka prathine parasparsanvadache kshetra aahe jeey anek sanrachanatmak aanee karyatmak vaividhyapurn bhagidaranna bandhanyat guntalele aahe. vanaspati, burshi, amiba aanee pranyanchya sarvat alikadil samanya purvajanchya kahee kalapurvi eukeriotsmadhye liim kshetra disu lagale. pranyanchya peshinmadhye, liim domain asaleli prathine anekada peshi kendrakamadhye, jithe teey januk abhivyakti niyantrit karoo shakatat, aanee peshidravyamadhye, jithe teey samanyatah peshi ekatra jodanyat guntalelya actin cytoskeletal sanrachananshi aanee aaspaschya matrixshee sambandhit asatat, jase qee taana tantu, phokal sanlagnata aanee anuyayi junction.
shodh.
liim domenla khaleel karye asalelya teen homeobox prathinanmadhil tyanchya prarambhik shodhavarun nave denyat aalee aaheth
kram aanee rachana.
manavanmadhye 73 varnan keleli januke asatat jee vegvegalya liim domain-yukt prathinanna encoding karatat. yaa liim domenmadhye zinkchya bandhanat guntalelya kahee pramukh avasheshanvyatirikt bhinn amino acid anukram aahet, jeey sthir prathinancha gabha aanee truteey putt tayar karnyas madat karatat. vividh seema kshetranmadhil krambhed haah sanrakshit sthir gabhanyachya varr vividh bhagidaransathi naveen bandhan sthalanchya utkrantimule asoo shakato. yavyatirikt, liim domain prathine karyatmakdrushtya vaividhyapurn asatat; visheshtah pranyanchya suruvatichya utkrantidarmyan, naveen karyakshamatesah hii vaividhyapurn prathine tayar karnyasathi liim domain itar vividh domain prakaransah punha ekatra kele jaate.
liim domenchi anukramank swakshari khalilpramane aaheh
[c]-[x] 2-4-[c]-[x] 13-19-[w]-[h]-[x] 2-4-[c]-[f]-[lvi]-[c]-[x] 2-4-[c]-[x] 13-20-c-[x] 2-4-[c]]
tess, ell. emm. oo. 4 sarkhya prathinanmadhye disalyapramane, liim domain varanvar gunankanmadhye aadhaltat aanee tyanchyavar bandhan kinwa lakshyikaran karya pradan karnyasathi itar domenshee dekhil jodale jaau shakatat, jase qee liim-keynage.
bhoomika.
peshi-asthipanjar sanghatana, avayavancha vikas, vanaspati peshinchya vikasache niyaman, peshi vanshanirdharan tapasheel aanee januk pratilekhan niyaman yamadhye liim-domain asaleli prathine bhoomika bajavtat asey disun aale aahe. liim prathine vividh prakarchya hriday aanee snayunchya sthitee, oncogenesis, majjasansthesambandhi vikar aanee itar roganmadhye dekhil guntaleli asatat. liim-domain anek vegvegalya pesheey prakriyanmadhye prathine-prathine parasparsanvadat madhyasthi karatat. tathapi, yantrik bharakhali asalelya actin cytoskeletal sanrachanansathi liim prathinancha eka motha upasanch nivadala jaato. limkadoon thet shakti-sakriy eff-actin bandhan heey tanalelya cytoskeletal jaalyanmadhye liim domain prathinanchi bharati karate aanee heey yantrik samvedan yantraneche eka udaharan aahe jyadvare cytoskeletal tanav yantrik homeostasis, nuclear sthanikikaran, januk abhivyakti aanee itar cellular shariravidnyan niyantrit karato.
vargikaran.
liim superclasschya janukanche 14 varganmadhye vargikaran kele gele aaheh ablim, see. aar. pii., enigma, applin, lasp, ell. etch. ex., ell. emm. oo., limak, ell. emm. oo. 7, maykal, pii. ex. aine., pinch, tess aanee zykes. yapaiki sahaa varg (i.eae.ablim, mikal, enigma, zykes, lhx, lm07) heey prani mool vanshamadhye ugam pavalele aahet aanee yaa vistarane pranyanchya bahukoshikatechya ugmamadhye mothe yogdan dile aahe asey manale jaate.
pranyanchya vanshavalisah, yojana liim janukancha eka sampoorn varg aahe jyache chaar vegvegalya varganmadhye vargikaran kele gele hoteh doubleu. ell. aay. emm. 1, doubleu. ell. aay. emm. 2, plim 1, plim 2 aanee flim (ex. ell. aay. emm.). hyanchi 4 vegvegalya upkutumbanmadhye vibhagani kelee jaateh αlim1, βlim1, γlim2 aanee δlim2. αlim1 upkhandanmadhye plim1, valim1 aanee flim (xlim) yancha samavesh hoto. βlim1 haah eka naveen upkutumb aahe, tyamule sadhya vegale karata yenyajogi upkhand naheet. γlim2 upkhandanmadhye Wlim2 aanee plim2 asatat. antim upkutumb δlim2 madhye Wlim2 aanee plim2 asatat.
liim domain vividh jivanu vanshanmadhye dekhil aadhaltat jithe teey samanyatah metallopeptidase domenmadhye misalale jaatat. kahee aavrutya tyanchya aine-terminswar nishkriy pii-loop aine. tii. pii. ess. aanee ekach transmembrane heliksmadhye fusion darshavtat. heey kshetra sanyojan soochit karatat qee procariotic liim kshetra peshi patalavar prathine prakriya niyantrit karanyachi shakyata aahe. kshetra vastushastriy vakyarachana hii bii-boxes zink boat aanee aine1 zink boat kshetranchya procariotic aavrutyanna ullekhaniyaritya samantar aahe.
prathine asalele liim domain, followers junction, cytoarchitecture, peshi dhruviyateche tapasheel, nuclear-cytoplasmic shuttle aanee prathinanchi taskari yasarkhi peshinmadhye anek vishisht karye karate. hii kshetre eucario, vanaspati, prani, burshi aanee mysetozoamadhye aadhalu shakatat. tyache aaa, buub, qa aanee daad asey vargikaran karnyat aale hote. heey vargikaran pudhe teen gatanmadhye vibhagalele aahe.
gut 1.
yaa gatat aaa aanee buub heey maryadit kshetra varg aahet. teey samanyatah kayanesesarkhya itar karyatmak kshetranshi jodale jaatat. yaa kshetransathi upvarg mhanje liim-homeodoman pratilekhan ghatak, ell. emm. oo. prathine aanee liim kinnesses.
liim-homeodoman pratilekhan ghatak.
tyanchyat bahukriyashilata pramukhyane majjasansthechya vikasavar, pratilekhan sakriy karnyavar aanee vikasadarmyan peshichya niyatiche tapasheel yavar kendrit asate. majjasanstha majjasancharak jaivasanshleshit marganchya bhinnatesathi neem kshetra prakaravar avalambun asate.
ell. emm. oo. prathine.
hii prathine anek prakarchya peshinchya sarvangin vikasavar tasech oncogenesis aanee transcriptional niyamnavar laksh kendrit karatat. tii-seela leukemiachya rugnanmadhye ell. emm. oo. 1 aanee ell. emm. oo. 2 chya abhivyaktimule oncogenesis jhalyache aadhalun aale.
kinesses maryadit qaraa.
yaa prathinancha uddesh cytoskeletonchi sthapana aanee niyaman karane haah aahe. yaa kayanesesdware cytoskeletonche niyaman kofilinchya phosphorylationdware hote, jyamule actin philaments jamaa hotat. visheshtah, teey peshinchi gatishilata aanee aakarjanan niyaman karnyasathi jababdar asalyache aadhalun aale aahe.
gut 2.
yaa gatamadhye see. vargatil liim domain aahe, jeey samanyatah peshidravamadhye sthanbaddh kele jaatat. hii kshetre prati prathine done prateensah antargatpane duplicate kelee jaatat. tasech, teey aaa aanee buub varganpeksha pratyekashi adhik samaan aahet.
systeinyukt prathine.
cysteine samruddha teen bhinn prathine aahet. yaa prathinancha uddesh myogenesis aanee snayunchya sanrachanet tyanchi bhoomika aahe. tathapi, asey aadhalun aale qee anek prakarchya peshinmadhye sanrachanatmak bhoomika bajavali jaate. pratyek see. aar. pii. prathine sampoorn myogenesismadhye sakriy hotat. see. aar. pii. 3 haah myoblastchya vikasat bhoomika bajavato, tarr see. aar. pii. 1 haah fibro blast peshinmadhye sakriy asato. see. aar. pii. 1 madhye actin philaments aanee myofiberschya zed reshanshi sambandhit adhik bhoomika aahet.
gut 3.
yaa gatamadhye fakt dii varg asato, jeey samanyatah peshirsamadhye sthanbaddh asatat. yaa liim prathinanmadhye 1 teey 5 kshetra asatat. yaa kshetranmadhye atirikt karyatmak kshetra kinwa rachana asoo shakatat. haah gut zyxine, paxillin aanee pinch yaa teen vegvegalya adaptor prathinanparyant maryadit aahe. tyanchya pratyekachya anukrame 3,4 aanee 5 saha vegvegalya sankhyene liim domain aahet. yaa peshi aakarache niyaman karananya aanee vishisht liim-madhyasthi prathine-prathine parasparsanvadvare pasarana sanlagnata plekshee sambandhit adaptor prathine manalya jaatat.
prathine-prathine parasparkriya.
liim-etch. dii. aanee ell. emm. oo.
hii prathine liim-etch. dii. chey vegvegale heterodimer tayar karnyasathi liim-ell. dii. bii. parasparsanvad sadhat, liim-1 neey bandhalelya liim domain bandhan kutumbanchya parasparsanvadvare tayar hotat. heey samanyatah eka liim-jhakan pradesh tayar karel joou liim prathinanshi sanvad sadhato. liim-etch. dii. heey vikasadarmyan motor neuronsasathi vishisht olakh nirdharit karnyasathi olakhale jaate. heey ell. emm. oo. 1, ell. emm. oo. 2, ell. etch. ex. 1, aay. ess. ell. 1 aanee emm. see. 3 yanna bandhanare asalyache aadhalun aale aahe. ell. emm. oo. 2 heey kendrakat sthanbaddh asalyache aadhalun aale aahe, jeey visheshtah garbhachya yakrutat erythroidchya vikasat guntalele aahe.
zyxine.
heey prathin shataldware peshiras aanee kendrak darmyan sthanbaddh kele jaate. heey peshi sanlagnata sthale aanee kendrak yanchyat halanyavar laksh kendrit karate. liim kshetrachi zink bote swatantrapane karya kartil. zyxinemadhye see. aar. pii., α-actinine, proto-oncogene vav, pii130 aanee prathinanchya eenaa/vasp kutumbatil sadasya asey vividh bandh bhagidar asatat. zyxineche dnyat parasparkriya eenaa/vasp aanee see. aar. pii. 1 darmyan asatat. see. aar. pii. 1 olakhanyasathi liim 1 jababdar aahe, parantu zyxinela bandhanyasathi liim 2 laa sahkarya karate. eenaa/vasp prophilinala bandhel jeey actin-polymerising prathin mhanoon karya karate. zyxine-vasp complexes cytoskeletal sanrachanesathi actin-polymerisation suru karel.
paxillin.
heey prathin kendrastha sanlagnatechya thikani peshidravamadhye sthanbaddh kele jaate. heey medyukt aaml aanee systoskeletal sanrachanechya vikasasathi madhyavarti prathine mhanoon karya karate. fatty acidsmadhye, teey anek bandhankartyansathi farshi mhanoon kaam karatat. see-terminalvaril liim domain prathine tyrosine phosphates-kitakanna bandhate. pii. tii. pii.-keetak see-terminai liim 3 aanee 4 varr fatty acidche pruthakkaran karnyasathi bandhale jaate jyamule fatty acid lakshyit pradeshanche modulation hoil. bandhan kitee pramanat aahe heey liim 2 aanee 4 varr avalambun asel. heey pii130 aanee paxillinchya defosphorylationvar hoil.
goodh.
heey prathin peshidravamadhye sthanbaddh kele jaate, jeey sanket aanee prathinanchya taskarimadhye kaam karate. yaa prathinanchya sanrachanet see-terminalvar teen liim domain asatat. heey liim domain 3 varr insulin receptor antargat rachana (aay. ess. aar. eff.) bandhel. liim domain 2 rett receptor tyrosine kinesala bandhate.
chimata.
heey prathin peshiras aanee kendrakat sthanbaddh kele jaate. sparsh receptor neuronschya vishisht snayu anuyayi junction aanee yantraksanvedi karyanvar parinam karnyasathi heey jababdar aahe. liim kshetrantil prathinancha kram atishay lahan interdomain peptides aanee see-terminal vistarasah uchch pramanat sakaratmak shulkasah jodalela aahe. vruddhavasthetil erythrocyte pratijananmadhyehi prathinanchi anek karye asatat. heey integreen-linked kinejachya ankirin repeat domenshee bandhale jaau shakate. tasech, chimatiche liim domain 4 heey eka adaptor mhanoon kaam karnyasathi aine. see. see. 2 prathinanshi bandhale jaau shakate.