
1bii asalele graam domain

1 bii asalele graam domain, jyala grammed1bii, ester-bii aanee kiaae1201 asehi mhanatat, heey collesterolche vahtook prathin aahe jeey grammed1bii janukadware encode kele jaate. tyat eka transmembrane pradesh aanee dnyat karyachi done kshetre aahet; graam domain aanee eka vishal domain. too endoplasmic reticulumla chikatoon asato. heey atyant sanrakshit januk vividh prushthavanshiy aanee aksherukiy pranyanmadhye aadhalate. homolog (lamm/ell. tii. see. prathine) yeastmadhye aadhaltat.
januk.
gramadi1bii, jyala kiaae1201 asehi mhanatat, manvi genomemadhe 11q24.1 varr sthit aahe. too + strandver sthit aahe aanee itar vividh janukanni vedhalela aahe. tyat 269,347 talancha samavesh aahe. 
emm. aar. aine. aii.
sarvat satyapit samaroop, samaroop 1 madhye 21 exon asatat. manvi gramadi1beeche chaar pramanit samaroop prakar aahet. yamadhye 5 'aanee 3' pradesh kapale jaatat, parinami eka exon nasht hoto. under janukache eka pramukh vishleshan grammady1beachyyaa eka prakaracha andaj lavte joou 699 amino acid lamb aahe.
prathine.
gramadi1bii heey eka avibhajya puttle prathine aahe jyamadhye anek kshetra, rachana aanee sanket asatat.
kshetra.
grammed1bii madhye done pushti kelele cytoplasmic kshetra aahet. prathinala tyache naav gramm domenvarun midale aahe, jeey suruvatichya kodanpasoon andaje 100 amino acid sthit aahe. gramm domain samanyatah myotubularine kutumbatil phosphatesmadhye aadhalate aanee pramukhyane puttle jodalelya prakriyanmadhye sameel asate. gramadi1bimadhye vishal (taara-sambandhit lipid hastantaranache wadd1 analogue) kshetra dekhil aahe. vishal kshetra pramukhyane chanyasarkhya lipid bandhan kshetranshi sambandhit aahe. heey mothya hydrophobic legandsla bandhanyat karya karanyachi shakyata jaast asate aanee sterolsathi vishisht asoo shakate. grammed1bii madheel see-terminal domain erchya lumenmadhye basate, alfa-helical duyyam rachana asalyacha andaj aahe aanee tryptophan see-manosalitiondware sudharit kele jaate.
rachana vaishishtye.
amino acid 232-267 aanee 348-377 pasoon done nakaratmak charge cluster aahet. pahila cluster jaast sanrakshit nahee, kinwa too ekhadya rupankanat kinwa domenmadhye sthit nahee. dusra samooh thet vishal kshetrachya samore sthit aahe aanee sanrakshit aahe.
teen punaravrutti anukram pradesh aahet, jeey serve orthologsmadhye byanpaiki sanrakshit aahet.
orthologsmadhye aanvik vajan aanee isoelectric bindu sanrakshit kele jaatat.
rachana.
prathinanmadhye chaar dialucine rachana asatat, teen graam domenmadhye kinwa tyachya jawal sthit asatat. eka andajit lucine zipper namuna jaree too anoo prathine nasla taree too transmembrane pradeshat bahutansh vistarato. eka summoilation site thet vishal kshetranantar sthit aahe. prathinanchya duyyam sanrachanet alfa-helices, beeta-strands aanee coil asatat. beeta-strands pramukhyane done kshetranmadhye sthit aahet, tarr alfa-helics transmembrane pradeshajaval kendrit aahet. sampoorn prathinanmadhye teen diasulphide bandhancha andaj vartavala jaato. 
upkoshikeey sthan.
grammed1bii heey transmembrane kshetradvare endoplasmic reticulummadhye lunger takale jaate.
abhivyakti.
gramadi1bii vividh uutinmadhye vyakt kele jaate. heey sarvat jaast gonadal ootee, adhivrukk granthi, mendu aanee nalmadhye vyakt hote. yamule adhivrukk arbude, fuffusachya arbudanmadhye abhivyaktiche praman vadhale aahe. vikasatmakdrushtya, heey balpanat sarvadhik vyakt kele jaate. ist profile anek strotankadun prayogik mahitisah samarthit aahe
samarupata.
orthologs.
grammed1bisathi ortholog space utkrantichya velechya mothya bhagavar pasarleli aahe. grammed1bii heey sastan prani, pakshi, maase aanee aprushthavanshi pranyanmadhye aadhalu shakate. yeastmadhye samaroop prathine (lamm/ell. tii. see.) aadhaltat.
paralog.
grammed1beacheeii chaar paralog aahet. sarvat jawalcha sambandh grammed1eshee aahe tarr sarvat durcha ortholog grammed2aii/grammed2 aahe. 
phylogeny.
grammed 2 heey itihasatil sarvat suruvatichya kalat vegale jhaale, tarr sarvat alikadil vibhajan grammed 1 aii aahe. grammed1bii janukacha vichalanacha darr fibrinogenpeksha lakshaniyaritya vegwan asato parantu cytochrome see itka jaast nasato. 
karya.
jevha plazma patalat collesterolchi patali jaast asate, tevha grammed1bii tasech grammed1aii aanee grammed1see heey plazma puttle aanee endoplasmic reticulum yanchyatil samparkachya thikani jaatat. grammed 1 prathine nantar endoplasmic reticulummadhye collesterolchi vahtook sulabh karatat. grammed1beechya babatit, collesterolcha plazma puttle srot uchch-ghanata lipoprotein (etch. dii. ell.) aahe. collesterolla bandhanyasathi vishal kshetra jababdar aahe, tarr gramm kshetra collesterolchi jaaniv karoon deuun aanee plazma patalamadhye, visheshtah phosphetidilserinemadhye anshatah nakaratmak charge kelele lipids bandhun prathinanche sthan tharavate.
grammed1bii haah peshimadhye carotenoidschya vahatukimadhye dekhil guntalela aahe.
prathinanchi parasparkriya.
anek vegvegalya prathinanchi prayogikdrushtya pushti jhaali aahe kinwa gramadi1beeshee parasparkriya hoil assa andaj vartavanyat aala aahe.
vaidyakeey mahatva.
utparivartan aanee itar anuvanshik abhyas grammady1beachaaa sambandh bauddhik apangatva aanee schizophrenia yasarkhya majjatantu vikasatmak vikaranshi jodatat. grammady1beachyyaa hanimule mootrapind granthitil collesterolcha sanchay aanee undaranmadhil seeram corticosteronchi patali qamee hote. gramadi1bii aanee gramadi1see qamee kelyane undaranmadhye alcoholic nasalelya charbiyukt yakrutachya rogachya, alcoholic nasalelya steatohepatitis (nash) eka prakarachi suruvat dadapali jaate.
dirghakalin lymphocytic leukemiyapasoonchya snapsla tagg karananya abhyasat grammady1bii haah dusra sarvat majboot jokhim asalela elil pradesh asalyache aadhalun aale. histone etch3 lycine 27 chey aniyamit trie-methylation sooj aanate aanee bruhadantratil arbudanmadhye grammady1bii patali vadhavate asey disun aale aahe, yaa sambandhala anek abhyasandvare samarthan dile jaate.