
ess. tii. keey. 11

serine/threonin kinness 11 (ess. tii. keey. 11) jyala liver kinness bii1 (ell. keey. bii. 1) kinwa mutrapindatil carcinoma pratijan aine. vaay.-raine-19 asehi mhanatat, haah eka prathine kinness aahe joou manavanmadhye ess. tii. keey. 11 janukadware encode keela jaato.
abhivyakti.
24 tasansathi murine 3tii3-ell1 kinwa manvi ess. jee. bii. ess. edipocyteschya testosterone aanee dii. etch. tii. upcharanmule androgen receptordware ell. keey. bii. 1 chey emm. aar. aine. aii. abhivyakti lakshaniyaritya qamee jhaali aanee parinami phosphorylationdware aii. emm. pii. keey. chey sakriyakaran qamee jhaale. yaulat, 17β-astradiol upcharamule ell. keey. bii. 1 emm. aar. aine. aii. madhye vaadh jhaali, joou istrogen receptor alfachya madhyasthicha parinam hota.
tathapi, eae. aar. positive stanachya karkarogachya peshi resheteel emm. see. eff.-7 madhye, estradiolamule ell. keey. bii. 1 pratilekhan aanee prathinanchya abhivyaktimadhye matra-aadharit ghat jhaali jyamule ell. keey. bii. 1 lakshya aii. emm. pii. keey. chya phosphorylationmadhye lakshaniy ghat jhaali. eae. aar. aii. aii. heey asthibandhan-swatantra paddhatine ess. tii. keey. 11 pravartkashi bandhale jaate aanee astradiolchya upasthitit haah parasparkriya qamee hoto. shivay, astradiolchya upasthitit ess. tii. keey. 11 pravartak kriyakalap lakshaniyaritya qamee jhaala aahe.
karya.
ess. tii. keey. 11/ell. keey. bii. 1". januk, jeey serine/threonin kinness kutumbatil sadasyala sanketikrut karate, peshi dhruviyateche niyaman karate aanee arbud dabnare mhanoon karya karate.
ell. keey. bii. 1 haah adenosine monofosphate-sakriy prathine kinness (aii. emm. pii. keey.) chaa prathamik upstream kinness aahe, joou peshi chayapachayatil eka aavashyak ghatak aahe joou urja homeostasis rakhanyasathi aavashyak aahe. aata heey spasht jhaale aahe qee ell. keey. bii. 1, aii. emm. pii. keey. aanee aii. emm. pii. keey.-sambandhit kinesescha samavesh asalelya itar 14 kinesescha gut sakriy karoon, tyachya vadhivar dadapshahiche parinam karate. urja aanee poshak tatvanchi patali qamee asatana ell. keey. bii. 1 dware aii. emm. pii. keey. chee sakriyata vaadh aanee prasar dadapate. ell. keey. bii. 1 dware aii. emm. pii. keey.-sambandhit kayanesesachi sakriyata peshinchi dhruviyata rakhanyat mahattvapoorn bhoomika bajavate jyamule arbud peshincha anuchit vistar rokhata yeto. sadhyachya sanshodhanatun eka chitra samore yet aahe qee ell. keey. bii. 1 chya hanimule peshinchi dhruviyata viskalit hote aanee urjechya pratikool paristhitit arbud vadhanyas madat hote. undaranvaril abhyasatoon asey disun aale aahe qee janmanantar cardiomyocytesmadhye ell. keey. bii. 1 abhivyaktiche niyaman kele jaate aanee ell. keey. bii. 1 chee vipulata navjat under cardiomyocyteschya prasarashi nakaratmakpane sambandhit aahe.
ell. keey. bii. 1 kriyakalap qamee hone heey atyant aakramak tichya 2 + stanachya karkarogashi sambandhit aahe. ell. keey. bii. 1' chya stun granthichya abhivyaktichya hanisathi tichya 2/neuro undaranchi rachana kelee gelee hotee, parinami tumergenesischi vilambata qamee jhaali. yaa undaranmadhye stun arbude vikasit jhaale jeey emm. tii. aar. sathee atyant chayapachay aanee atisakriy hote. emm. tii. aar. aanee chayapachayala ekach velee lakshya karananya purv-vaidyakeey abhyasanni anukrame aii. zed. dii. 8055 (emm. tii. aar. see. 1 aanee emm. tii. aar. see. 2 chey avarodhak) aanee 2-dii. jee. neey stun arbud tayar honyapasoon rokhale. stun arbud nasalelya niyantrit undaranmadhye mitochondria karya aii. zed. dii. <aay. dii. 1>-dii. jee. upcharanni prabhavit jhaale nahee.
pieutz-jeghars syndromedhye aadhalanare ell. keey. bii. 1 utprerak kamatarata utparivartak oncogenechya pravartkamadhye pratisad ghatakanchya bharatidvare cycline dii 1 chee abhivyakti sakriy karatat. ell. keey. bii. 1 utprerakdrushtya kamatarata asalelya utparivartananmadhye oncogenic gunadharm asatat.
vaidyakeey mahatva.
yaa janukamadhye rog nirman karnare kiman 51 utparivartan aadhalale aahet. yaa janukatil germline utparivartan heey petz-jeghars syndromeshy sambandhit aahet, eka autosomal dominant disorder jeey jatharantra margatil polypschee vaadh, tvacha aanee tondavaril rangdravyayukt mccules aanee itar nioplajamsdware darshavile jaate. tathapi, ell. keey. bii. 1 januk dekhil fuffusachya karkarogamadhye, pramukhyane adenocarcinomedhye, viralpane udbhavalelya karkarogamadhye utparivartit jhalyache aadhalun aale. pudhe, alikadil abhyasanmadhye ell. keey. bii. 1 janukatil mothya sankhyene sharirik utparivartan ughad jhaale aahet jeey grivechya, stanachya, aatadyanchya, vrushananchya, swadupindachya aanee tvachechya karkarogamadhye asatat.
ell. keey. bii. 1 heey dukhapatinantar hriday punarutpadan prerit karnyasathi sambhavya lakshya mhanoon samavisht kele gele aahe kaaran cardiomyocyteschi punarutpadak kshamata praudh sastan pranyanmadhye maryadit aahe. undaranchya cardiomyocytesmadhil ell. keey. bii. 1 chya ghasaranimule aii. emm. pii. keey. chey phosphorylation dabale gele aanee hoy-sambandhit prathine sakriy jhaali, jyamule nantar cardiomyocyte prasarala chalana midali.
sakriy karane.
ell. keey. bii. 1 heey seudokinase strad aanee adaptor prathine emm. oo. 25 laa jodoon allosterically sakriy kele jaate. ell. keey. bii. 1-strad-emm. oo. 25 heterotremeric complexes jaivikdrushtya sakriy unitche pratinidhitva karate, jeey phosphorylating aanee sakriy karnyas saksham aahe. stradache anek naveen splies isophorms jeey ell. keey. bii. 1 kriyakalap, jatil assembly, ell. keey. bii. 1 chey upkoshikeey sthanikikaran aanee ell. keey. bii. 1-aashrit aii. emm. pii. keey. margache sakriyakaran yavar bhinn parinam karatat.
rachana.
ksh-kiran sfatikalekhan vaparoon ell. keey. bii. 1-strad-emm. oo. 25 sankulachi sphatik rachana spasht karnyat aalee aanee jyadvare ell. keey. bii. 1 allosterically sakriy aahe tee yantrana ughad karnyat aalee. ell. keey. bii. 1 chee rachana itar prathinanchya kinesachi vaishishtyapurn aahe, ligand aii. tii. pii.-binding pocketchya donhi bajunna done (lahan aanee mothe) lobe aahet. ell. keey. bii. 1 sakriy sanrachana vadhavanyasathi strad aanee emm. oo. 25 ekatra sahkarya karatat. kinage sakriy karnyachya prakriyetil eka mahattvacha ghatak, ell. keey. bii. 1 sakriyakaran loop, emm. oo. 25 dware sthanbaddh keela jaato, asha prakare strad aanee emm. oo. 25 chya upasthitit ell. keey. bii. 1 kriyakalapatil prachand vaadh spasht karate.
splies prakar.
yaa janukache paryayi pratilekhan splies prakar pahile gele aahet aanee tyanche vaishishtya darshavile gele aahe. ell. keey. bii. 1 lamb (ell. keey. bii. 1 "ell") aanee ell. keey. bii. 1 lahan (ell. keey. bii. 1 "ess") asey done mukhya splies isophorm darshavile jaatat. lahan ell. keey. bii. 1 prakar pramukhyane vrushananmadhye aadhalato.
parasparsanvad.
ess. tii. keey. 11 saha sanvad sadhatana dakhavale gele aaheh