
tetratricopeptide punaravrutti

tetratricopated repeat (tii. pii. aar.) hii eka sanrachanatmak rachana aahe. tyat vividh prakarchya prathinanmadhye olakhalya gelelya 34 amino aesidchya punaravartanachi adhogati asate. heey 3-16 rupankananchya ektrit rachnet aadhalate, jeey prathine-prathine parasparsanvad aanee anekada bahuprathine sankulanchya ektritatemadhye madhyasthi karnyasathi farsha tayar karatat. hii alfa-helics jodee samanyatah tii. pii. aar. domain navache eka, resheey solenoid domain tayar karnyasathi ekatra dumadate. asha kshetrantil prathinanmadhye anaphase-protsahan denare complexes (aii. pii. see.) upghatak see. dii. see. 16, see. dii. see. 23 aanee see. dii. see. 27, naduff auxidase upghatak pii. 67-fox, etch. ess. pii. 90-binding immunophiline, pratilekhan ghatak, prathine keynage aar (pii. keey. aar.), peroxisomal matricks prathine aayat karnyasathi pramukh receptor pii. eae. ex. 5, prathine arginine methyltransferess 9 (pii. aar. emm. tii. 9) aanee mitochondrial aayat prathine yancha samavesh hoto.
rachana.
pii. pii. 5 prathinanchi rachana hii nirdharit kelee jaanari pahili rachana hotee. daas aanee tyanchya sahakanyanni ksh-kiran sphatikalekhanadvare sodavalelya sanrachanene asey darshavile qee tii. pii. aar. anukramachi rachana hii samantar alfa helisesachya jodine banaleli hotee. pii. pii. 5 sanrachanet 3 tandam tii. pii. aar. punaravrutti hotya, jyat anukramik tii. pii. aar. punaravrutti alfa-helical solenoid rachana tayar karat asalyache disun aale.
eka vaishishtyapurn tii. pii. aar. rachana hii pahilya rupareshechya aaa aanee buub helics aanee pudhil tii. pii. aar. chya aaa 'helics yanchyatil parasparsanvadvare darshavili jaate. jaree asha parasparsanvadache swaroop bhinn asoo shakate, taree tii. pii. aar. rachanechya pahilya done helisesacha packing coone samanyatah ekach rachnet ~ 24 anshancha asato. teenpeksha jaast tii. pii. aar. rachana punha punha kelyas ujavya hatacha superhelics tayar hoto, jyache vaishishtya avtal aanee bahirmukh assa donhi prakarcha chehara asato, jyapaiki avtal chehara samanyatah legandchya bandhanimadhye guntalela asato. 
kramachya drushtine, tii. pii. aar. madhye lahan aanee mothya hydrophobic avasheshanche mishran asate, tathapi, konatihi sthitee purnapane aparivartaniy nasate. tathapi, asey kahee avashesh aahet jeey samanyatah sanrakshit kele jaatat, jyat tryptophan 4, lucine 7, glycine 8, tyrosine 11, allenine 20, fenilalenin 24, allenine 27 aanee prolin 32 yancha samavesh aahe. tyaa 8 paiki, 8,20 aanee 27 sthananvar asalele allenine adhik sanrakshit asatat. itar sthananmadhye vishisht avasheshanaivaji lahan, mothe kinwa sugandhit amino acidna adhik pradhanya asate. helixchya darmyan, helics todanare avashesh upasthit asalyane avashesh sanwardhan adhik sanrachanatmak bhoomika bajavate. jawalchya tii. pii. aar. darmyan, avasheshanchya sanrachanatmak aanee karyatmak asha donhi parinamansah bhoomika asatat.
tii. pii. aar. madhye peptides asatat.
hopp.
hopp adaptor prathine aanvik chepron etch. ess. pii. 70 aanee etch. ess. pii. 90 chya sambandhat madhyasthi karatat. tyat pratyeki teen-tii. pii. aar. punaravrutti asatat, jyanchi swatachi peptide-bandhan vishishtata asate. tyache tii. pii. aar. 1 kshetra etch. ess. pii. 70 chey see-terminal olakhanyasathi olakhale jaate, tarr tii. pii. aar. 2 heey etch. ess. pii. 90 chya see-terminalshee bandhale jaate. donhi see-terminal anukram eae. eae. dii. dii. rachnesah sampatat aanee parasparsanvadache swaroop electrostatic aanee hydrophobic donhi aahe.
pii. eae. ex. 5.
pakes5 prathine hii pii. tii. ess. 1 (peroxisomal target signal tripeptide jeey prathinanna peroxisomesmadhye nirdeshit karate) sathee eka receptor aahe. tii. pii. aar. rupandware teey sanketashi sanvad sadhate. see-terminal tripetide pii. tii. ess. 1 saha tyache bahutek sampark tii. pii. aar. ess. 1,2 aanee 3 chya avtal prushthbhagat aahet.
neutrophil cytosolic ghatak 2.
neutrophil cytosolic ghatak 2 haah naduff auxidase sankulasathi aavashyak aahe, joou sukshmajivanchya sansargala pratisad mhanoon superoxide tayar karato. rack jee. tii. paces. chey bandhane hii sankulachya jodanichi eka mahattvachi payari aahe aanee fox unitmadhil tii. pii. aar. heey bandhanicha farsha vaparoon bahuprathine sankulachya jodanimadhye madhyasthi karatat.
udaharane.
hii rachana asalelya prathinanche sanketan karananya manvi janukanmadhye khaleel goshtincha samavesh hotoh