homocetrullin

-homocetrullin heey eka amino aaml aahe aanee sastan pranyanchya (manvi) chayapchayamadhye ornithinche chayapachay aahe. euria chakr vikar asalelya vyaktinchya mutrat amino aaml mothya pramanat aadhalu shakate. sadhya asey manale jaate qee ornithinchya purvathyat ghat jhalyamule euria chakrat carbamile-phosphet jamaa hote jeey homocetrullin aanee homoargininchya vadhiv sanshleshanasathi jababdar asoo shakate. donhi amino aaml mutrat aadhalu shakatat. amino acid vishleshan mootra kinwa raktasarkhya jaivik dravpadarthanmadhil yaa amino acid chayapachayanchya parimanatmak vishleshanas anumati dete.
varnan.
homocetrullin haah eka methylene gut aahe joou citrulinpeksha lamb aahe, parantu sanrachanet samaan aahe. lycine scienetshee pratikriya dilyanantar licinechya avasheshatun chayapachay tayar hote. manvi sharirat yuriyachya samatolat scienet asate. sharirik paristhitit yuriyache praman khoop qamee asoo shakate jyamule vyapak carbamilation houu shakate. tathapi, prathinanmadhye laisinpasoon homocetrullin tayar honyat karanibhoot honari rupantaran prakriya vivomadhye ghadate asey dnyat aahe. mootrapind nikami honyachya paristhitit yuriyache praman vadhate aanee anek prathinanche carbamilation houu shakate, jeey shodhale jaau shakate. asey manale jaate qee bahutek carbamilation jaljalichya darmyan hote jevha myeloperoxidase heey enzyme neutrofilsmadhun sodale jaate. heey enzyme thiocyanetche sinetmadhye rupantar karate. scienetchi vadhaleli patali aata carbamyelet lycine avashesh banavoo shakate.
neutrofilmadhun sodanyat yenare myeloperoxidase thiocyanetche sinetmadhye rupantar karate jeey carbamyelet karoon lycine avashesh tayar karoon homocetrullin tayar karate. thiocyanate (ess. see. aine.-) heey naisargikaritya aadhalanare seudohaloid aahe jeey aahar strotanmadhye aadhalate. myeloperoxidase scienet tayar karnyasathi hydrogen peroxide peroxide saha ekatra cosubstrate mhanoon ess. see. aine.-vaparu shakato. mutrapindatil bighad asalelya rugnanmadhye yuriyacha star vadhato. euria scienet aanee isocyanetchya samatolat aahe. nucleophilic amino gatanche carbamilation, udaharanarth lycine avashesh, prathinanchya sanrachanet badal karoo shakatat aanee shevati chayapachay vikaras karanibhoot tharoo shakatat.
aajaranmadhye.
citrulinated prathine/peptidesna lakshya lakshya sandhivatachya sandhivatachya pratipindansathi eka gondhal ghalanara pratijan mhanoon homocetrullin suchavale gele aahe. sandhivatachya sandhivatachya rugnanchya seramadhye homocetrullin-yukt anukramanshi bandhalelya pratipinde alikadech aadhalali aahet, heey darshavile gele aahe qee homocetrullin-yukt prathine sandhivatachya sandhyanmadhye (aar. aii.) asatat. kruntakanmadhye teey tii-peshila chalana denyavar aanee bahudha svayampratibandhak nirmitivar parinam karoo shakatat aanee bahudha manavanmadhyehi.
1969 madhye pahilyanda varnan kelelya hyperornithenamia-hyperamonemia-homocetrulinuria (etch. etch. etch.) syndromedhye, syndromedhye chayapachay vikarat, ornithinchi patali samanya patalichya tulanet paach teey daha patine vadhali asel. yavyatirikt, yaa lakshansamuchchayamadhye, allenine, aurotic acid aanee homocitrulinchi patali dekhil vadhu shakate. hyperamonemia asalelya lokanmadhye, uchch prathinyukt aaharanantar, orotic acid aanee homocetrullin dirghkal vadhalele disatat, parantu upvas kartana teey samanya asoo shakate.
chayapachay vikar, lyceneuric prathin asahishnuta hii sharirachya kahee prathinanche nirman karnare ghatak kinwa amino acid pachavanyat aanee vaparnyat asamarthatemule hote. teey aahet lycine, arginine aanee ornithin. hii amino aaml anek prathineyukt padarthanmadhye aadhaltat. yaa vikarat manvi shareer yaa amino acidche prabhavipane vighatan karoo shakat naslyamule lokanna samanyatah prathinanni samruddha asalele padarth khallyanantar malmal aanee ulatya hotat. yaa prathin asahishnutechya sambandhit vaishishtyanmadhye yakrut aanee pleeha vadhane, qamee unchi, snayuncha kamkuvatpana, rogpratikarak karyat bighad aanee fracture honyachi shakyata asaleli haloohaloo thisul honari hadey aanee pulmonary alviolar proteinosis navacha fuffusacha vikar dekhil vikasit houu shakato. yavyatirikt, mutrapindanmadhye amino acidche sanchay jhalyamule antim tappyatil mootrapind rog (eae. ess. aar. dii.) houu shakato. mutrapinde aata shariratil drav aanee kachara utpadane prabhavipane filter karoo shakat naheet.

