
lasika granthi

lasika granthi kinwa lasika granthi haah lasika pranalicha aanee anukool rogpratikarak pranalicha mutrapindachya aakaracha avyav aahe. lasika vahinyandvare mothya sankhyene lasika granthi sampoorn sharirat jodalelya asatat. tee lymphocyteschi pramukh thikane aahet jyat bii aanee tii peshi samavisht aahet. lasika granthi rogpratikarak pranalichya yogya karyasathi mahattvachya asatat, karkarogachya pesheensah bahya kanansathi filter mhanoon kaam karatat, parantu tyanche konatehi nirvishikaran karya nasate.
lasika pranalimadhye lasika granthi haah duyyam lasika avyav asato. lasika granthi tantumay capsulemadhye bund asate aanee tee bahya aachchadan aanee aateel medulane banaleli asate.
lasika granthi vividh roganmadhye soojatat kinwa vadhatat, jyat ghashachya kshullak sansargapasun teey jivghenya karkarogaparyant asoo shakatat. karkarogachya avasthemadhye lasika granthichi sthitee khoop mahattvachi asate, jee vaparnyasathi upchar tharavate aanee rognidan tharavate. lymphadenopathy mhanje vadhalelya kinwa sujalelya granthi. jevha sooj yete kinwa vadhate, tevha lasika granthi ghatt kinwa komal asoo shakatat.
rachana.
lasika granthi mootrapind kinwa andakar aakarachya asatat aanee tyanchya lamb akshavar 2 miimii teey 25 miimii paryantchya aakarachya asatat, jyaa sarasari 15 miimii asatat.
pratyek lasika granthila tantumay capsulene vedhalele asate, jee lasika granthichya aat pasaroon trabecula tayar karate. lasika granthicha padarth bahya 'aachchadan' aanee aateel 'medula' madhye vibhagala jaato. heey peshinni samruddha aahet. hilam haah lasika granthichya avtal prushthbhagavaril eka indent aahe jithe lasika vahinya baher padatat aanee raktavahinya aat yetat aanee baher padatat.
lasika anek sanlagn lasika vahinyandvare lasika granthichya bahirmukh bajula pravesh karate aanee tethoon sinuschya malikemadhye vahate. shoshak raktavahinyanmadhun lasika granthimadhye pravesh kelyanantar, lasika up-capsular sinus navachya capsulechya khalee asalelya jaaget vahate, nantar cortical sainasmadhye. aachchhadanatun gelyanantar, lasika nantar medpeshiy sainasmadhye gola hote. heey serve sinus avtal bajuchya hilamchya nodmadhun baher padnyasathi utsarjit lasika vahinyanmadhye vahoon jaatat.
thikan.
lasika granthi sampoorn sharirat asatat, teey khodachya jawal aanee aat adhik kendrit asatat aanee gatanmadhye vibhagalya jaatat. praudhanmadhye sumare 450 lasika granthi asatat. kahee lasika granthi mothya jhalyavar (aanee kadhikadhi jevha nasatat) jaanvu shakatat, jase qee bahuchya khalee aksheey lasika granthi, doke aanee manechya grivechya lasika granthi aanee mandichya khilkanjavalachya vandhyatvachya lasika granthi. bahutek lasika granthi shariratil itar pramukh sanrachananchya shejari asalelya khodamadhye asatat-jase qee paraortic lasika granthi aanee shwasanalikemadhil lasika granthi. lasika nichara paddhati vyaktinusar bhinn asatat aanee ekach sharirachya pratyek bajula vishamata dekhil asate.
madhyavarti majjasansthemadhye lasika granthi nasatat, jyaa rakt-menduchya adthalyamule sharirapasoon vegale hotat. see. aine. ess. madheel meningial lasika vahinyanmadhun lasika khol grivechya lasika granthimadhye jaate.
upavibhag.
lasika granthi 'nodules' (kinwa lobules) navachya vibhaganmadhye vibhagali jaate, pratyekamadhye sanyukt follical bii pesheensah cortexcha eka bhag, tii peshincha paracortex aanee medulamadhil nodulecha eka bhag asato. lasika granthicha padarth bahya 'aachchadan' aanee aateel 'medula' madhye vibhagala jaato. lasika granthicha aachchadan haah granthicha bahya bhag asato, capsule aanee up-capsular sinuschya khalee asato. tyacha eka bahya bhag aanee eka khol bhag aahe jyala 'paracortex' mhanatat. bahya aachchhadanamadhye pramukhyane nishkriy bii peshinche gut asatat jyanna follicals mhanatat. jevha sakriy hotat, tevha teey ankur kendra mhanoon vikasit houu shakatat. sakhol paracortexmadhye pramukhyane tii peshi asatat. yethe tii-peshi pramukhyane dendritic peshinshi sanvad sadhatat aanee reticular jaale daat asate.
medulamadhye mothya raktavahinya, sinus aanee medulary cord asatat jyat pratipind-srav karananya plazma peshi asatat. medulamadhye qamee peshi asatat.
medpeshiy dorr yaa lasika uutinchya dorr asatat aanee tyat plazma peshi, macrophage aanee bii peshi samavisht asatat.
peshi.
lasika pranalimadhye lasika granthi haah duyyam lasika avyav asato. lasika granthimadhye lymphocytes asatat, jeey pandhya raktapesheencha eka prakar aahe aanee pramukhyane bii peshi aanee tii peshi miloon tayar hotat. buub peshi pramukhyane bahya aachchhadanamadhye aadhaltat jithe tyaa lasikachya thipkyanmadhye follicular bii peshi mhanoon ekatra gumphalelya asatat aanee tii peshi aanee dendritic peshi pramukhyane 'paracortex' madhye aadhaltat.
aachchhadanapeksha medulamadhye qamee peshi asatat. medulamadhye plazma peshi asatat, tasech macrophages asatat jeey medulary sainasmadhye asatat.
reticular jaalyacha eka bhag mhanoon, bii peshichya thipkyat follicular dendritic peshi aanee tii peshichya aachchhadanamadhye fibroblastic reticular peshi asatat. reticular jaale sanrachanatmak aadhar aanee dendritic peshi, macrophage aanee lymphocytes sanlagnatesathi prushthbhag pradan karate. heey uchch endothelial veneulsdware raktasah samagrichi devanghevan karnyas dekhil anumati dete aanee rogpratikarak peshinchya sakriyatesathi aanee paripakvatesathi aavashyak vaadh aanee niyamak ghatak pradan karate.
lasika pravah.
lasika anek sanlagn lasika vahinyandvare lasika granthichya bahirmukh bajula pravesh karate, jee lasika vahinyanche jaale tayar karate () aanee yethoon up-capsular sinus navachya capsulechya khalee () jaaget vahate. yethoon, aachchadanachya aat lasika sainasmadhye vahate. aachchhadanatun gelyanantar, lasika nantar medpeshiy sainasmadhye gola hote. heey serve sinus avtal bajuchya hilamchya nodmadhun baher padnyasathi utsarjit lasika vahinyanmadhye vahoon jaatat.
heey tantumay reticular pesheensah endothelial peshinni rekhit kelelya nodmadhil vahinya aahet, jyamule lasikacha suralit pravah houu shakato. subcapsular sinusche endothelium heey affarent lymph vessels aanee trabeculachya bajula aanee cortexchya aat asalelya samaan sinusses dekhil akhand asate. yaa vahinya lahan asatat aanee macrophageschya margas parvanagi dett naheet jenekarun tyaa lasika granthimadhye karya karnyasathi maryadit rahtil. lasika darmyan, rogpratikarak pratisadasathi anukulatecha bhag mhanoon lasikapeshi sakriy houu shakatat.
sahasa fakt ekach sandapani asate, matra kahivela done asoo shakatat. medulary sainasmadhye hysteocytes (sthir macrophages) aanee reticular peshi asatat.
lasika granthimadhye lasika ootee asatat, i.eae., 'pandhya raktpesheensah' navache jaali kinwa tantu tyat gumphalele asatat. jaalikamamadhye jyaa bhagat kahee peshi asatat tyanna 'asey mhanatat. reticular peshi, fibroblast aanee sthir macrofagedware teey rekhit kele jaate.
capsule.
reticular sanyoji uutinche patal reticular fiber (reticulin) nodchya aat eka sahayyak jaali tayar karatat.
lasika granthiche capsule kahee sadhya kolejanyukt tantunsah ghan aniyamit jodana uutinni banalele asate aanee anek padada prakriya kinwa trabecula tyachya antargat prushthbhagapasun vistartat. parigh aanee nodchya madhyabhagi asalelya jagechya sumare eka trutiyansh kinwa eka chaturthansh jagesathi, nodchya madhyabhagi vikiranit houn, trabecula aatoon jaate. kahee pranyanmadhye teey nodchya paridhiy kinwa cortical bhagala anek vibhaganmadhye (gathee) vibhajit karnyasathi purese changle chinhankit kele jaatat, parantu manavanmadhye hii vyavastha spasht nahee. capsulemadhun ugavanare mothe trabecula sookshm pattyanmadhye vibhagatat aanee heey parasparanchya darmyan jaaun nodchya madhyavarti kinwa madhyavarti bhagat jaali tayar karatat. interlacing trabeculadware tayar jhalelya yaa trabacular jaganmadhye yogya lasika granthicha padarth kinwa lymphoid ootee asatat. tathapi, node palp jaaga purnapane bharat nahee, parantu tyachya bahya simareshechya aanee vedhalelya trabeculamadhye eka vahini kinwa sampoorn eksaman rundichi jaaga sodate. yala subcapsular sinus (lasika marg kinwa lasika sinus) mhanatat. tyachya palikade reticular fiberche anek sookshm trabecula aahet, jeey bahutek vela remifying peshinni jhakalele asatat.
karya.
lasika pranalimadhye lasika granthi haah duyyam lasika avyav asato. 
sansarg olakhanyasathi aanee tyachyashi ladhanyasathi lasika galane heey lasika granthiche prathamik karya aahe. heey karnyasathi, lasika granthimadhye lymphocytes asatat, eka prakarcha pandhara rakt peshi, jyamadhye bii peshi aanee tii peshi asatat. heey raktpravahatun pasaratat aanee lasika granthimadhye pravesh karatat aanee rahatat. buub peshi pratipinde tayar karatat. pratyek pratipindache ekach purvanirdharit lakshya asate, eka pratijan, jyashi teey bandhale jaau shakate. heey sampoorn raktpravahat pasaratat aanee jarr tyanna heey lakshya sapadale tarr pratipinde tyachyashi bandhali jaatat aanee rogpratikarak pratisad uttejit karatat. pratyek bii peshi vegvegalya pratipinde tayar karate aanee hii prakriya lasika granthimadhye chalavali jaate. asthimajjamadhye tayar honanya 'bholya' peshi mhanoon buub peshi raktpravahat pravesh karatat. lasika granthimadhye pravesh kelyanantar, teey nantar lasika koopamadhye pravesh karatat, jithe teey gunakar karatat aanee vibhajit hotat, pratyekjan eka vegali pratipinde tayar karato. jarr peshi uttejit jhaali tarr tee adhik pratipinde (plazma peshi) tayar karel kinwa sharirala bhavishyatil sansargashi ladhanyas madat karnyasathi smrutee peshi mhanoon karya karel. jarr peshi uttejit jhaali nahee, tarr tee apoptosismadhun jaeel aanee marel.
pratijan heey jivanunchya peshinchya bhintinvar aadhalanare renu, jivanunmadhun stravalele rasayanik padarth kinwa kadhikadhi sharirachya uutinmadhyech asalele renu dekhil asatat. dendritic peshinsarkhya pratijan-sadar karananya peshi navachya peshi heey sampoorn shariratil peshindware ghetale jaatat. heey pratijan peshi lasika pranalimadhye aanee nantar lasika granthimadhye pravesh karatat. teey tii peshinna pratijan sadar karatat aanee jarr yogya tii seela receptors tii seela asel tarr too sakriy hoil.
buub peshi thet shoshak lasikapasoon pratijan prapt karatat. jarr bii peshi tyachya sandnyanatmak pratijanala bandhat asel tarr teey sakriy hoil. kahee bii peshi lagech plazma peshi sravit karananya pratipindemadhye vikasit hotil aanee aay. jee. emm. sravit kartil. itar bii peshi pratijan antargat kartil aanee teey bii aanee tii peshi kshetra interfacevaril follicular helper tii peshinsamor sadar kartil. jarr cognet eff. tii. seela aadhalala tarr too see. dii. 40. ell. chey niyaman karel aanee bii selchya soometik hypermutation aanee isotype class switchingla protsahan deil, jyamule tyache pratijan bandhan sambandh vadhel aanee tyache prabhavak karya badalel. lasika granthimadhye peshincha prasar jhalyane granthicha vistar hoil.
lasika sampoorn sharirat asate aanee lasika vahinyandvare prasarit hote. heey lasika granthimadhye aanee tyatoon vahatat, sahayak vahinya granthimadhye vahatat aanee granthitoon vahinya vahatat. jevha lasika drav eka nodmadhye pravesh karato, tevha too subcapsular sinus navachya jaaget capsulechya agadi khalee nodmadhye jaato. up-capsular sinus heey trabacular sainasmadhye aanee shevati medulary sainasmadhye jaate. sayanasachi jaaga macrophageschya seudopodsne crass-cross kelee aahe, jee parkeey kananna adakavoon lasika filter karanyachi karya karate. medulary sinus hilam aanee lymphmadhye ekatra yetat aanee nantar lymph nodala 'utsarjit lasika vahini' dware ektar adhik madhyavarti lasika nodchya dishene kinwa shevati madhyavarti shiranchya subclavian raktavahinimadhye nichara karnyasathi sodatat.
vaidyakeey mahatva.
sooj yene.
lymph node vadhane kinwa sooj yene yala lymphadenopathy mhanatat. sooj hii sansarg, gathee, svayampratikar rog, aushadhanchya pratikriya, amyloidosis aanee sarcoidosis yasarkhe rog kinwa lymphoma kinwa leukemias anek karananmule asoo shakate. karananusar, sooj vednadayak asoo shakate, visheshtah jarr vistar jalad asel aanee sansarg kinwa jaljal jhalyamule asel. lasika granthichi vaadh ekhadya bhagat kelee jaau shakate, jee sansargacha sthanik srot kinwa lasika granthimadhye pasarlelya tyaa bhagatil gaath soochit karoo shakate. heey samanyikrut dekhil kele jaau shakate, jeey sansarg, sanyoji ootee kinwa svayampratikar rog kinwa lymphoma kinwa leukemiyasarkhya raktapeshinchi ghatakata soochit karoo shakate. kvachitach, sthananusar, lasika granthichya vadhimule shwas ghenyas tras hone kinwa raktavahinyanche sankuchit hone (udaharanarth, uchch veena cava adthala) yasarkhya samasya udbhavu shakatat.
vadhalelya lasika granthi vaidyakeey tapasanicha bhag mhanoon jaanvu shakatat kinwa vaidyakeey pratimevar aadhalu shakatat. vaidyakeey itihasachi vaishishtye karanakade nirdesh karoo shakatat, jase qee sooj yenyacha veg, vedna aanee taap kinwa vajan qamee hone yasarkhi itar ghatanatmak lakshane. udaharanarth, stanachya arbudamule bahunkhalil lasika granthi suju shakatat aanee vajan qamee houu shakate aanee ratri gham yene lymphoma sarkhya ghatakateche sanket deu shakate.
vaidyakeey vyavsayikadvare vaidyakeey tapasani vyatirikt, vaidyakeey chachanyanmadhye rakt chachanyancha samavesh asoo shakato aanee kaaran pudhil tapasanisathi scanchi aavashyakta asoo shakate. lasika granthichi biopsy dekhil aavashyak asoo shakate.
karkarog.
lasika granthi lasika uutinchya prathamik karkarogamule aanee sharirachya itar bhaganvar parinam karananya duyyam karkaroganmule prabhavit houu shakatat. lasika uutinchya prathamik karkaroganna lymphoma mhanatat aanee tyat hodgkin lymphoma aanee naun-hodgkin lymphoma yancha samavesh hoto. lasika granthichya karkarogamule vedanahin dirghakalin haloohaloo vadhana soojepasoon teey achanak, divas kinwa aathvadyant vegane vadhanyaparyant, arbudachya darjavar avalambun asalelya lakshanansah lakshananchi vistrut shreni houu shakate. bahutek lymphoma heey bii-peshinche arbud asatat. lymphomache vyavasthapan raktarandakshastradnya aanee karkarogshastradnya karatat.
sharirachya anek bhaganmadhil sthanik karkarogamule lasika granthi mothya houu shakatat kaaran gathinmadhye metastasis jhalelya tumour peshi asatat. karkarogachya nidan aanee upcharanmadhye lasika granthicha sahbhag haah anekada eka mahattvacha bhag asato, joou tii. aine. emm. avasthapanamadhye aanee itar karkarog avasthapanachya pranalinmadhye samavisht kelelya sthanik rogache "snrakshak" mhanoon kaam karato. karkarogachya tapasanicha kinwa vyayam karnyacha eka bhag mhanoon, lasika granthi pratimachitrit kelya jaau shakatat kinwa agadi shastrakriyedvare dekhil kadhoon takalya jaau shakatat. kadhoon takalyas, karkarograst disana peshinche purave aahet qaa heey nirdharit karnyasathi rogshastradnyadvare sukshmadarshakakhali lasika granthivar daag lavala jaeel aanee tyachi tapasani kelee jaeel (i.eae. nodmadhye metastasise kelele aahet). karkarogachi avastha aanee mhanoon upcharancha drushtikon aanee purvasoochana, node metastesachya upasthitivar aadharit aahe.
lymphedema.
lymphedema hii uutinchya soojechi (sooj) sthitee aahe jee lasika pranalidware apuri safsafaishi sambandhit aahe. samanyatah avikasit kinwa anupasthit lasika granthimule heey janmajat asoo shakate aanee yala prathamik lymphedema mhanoon olakhale jaate. lymphedema samanyatah haat kinwa payanmadhye udbhavato, parantu chhatichi bhint, jannendriye, maan aanee otipotatahi houu shakato. duyyam lymphedema samanyatah stanachya karkarogachya shastrakriyedarmyan lasika granthi kadhoon takalyamule kinwa kiranotsargasarkhya itar hanikarak upcharanmule hoto. heey kahee parjivi sansarganmulehi houu shakate. prabhavit uutinna sansargacha motha dhoka asato. lymphedemachya vyavasthapanamadhye vajan qamee karnyacha sallah, vyayam, prabhavit avyav olsar thevane aanee prabhavit bhag sankuchit karane yancha samavesh asoo shakato. kadhikadhi shastrakriyechya vyavasthapanachahi vichar keela jaato.
samaan lasika avyav.
pleeha aanee tonsils heey mothe duyyam lymphoid avyav aahet jeey lymph nodeshey kahee pramanat samaan karya karatat, jaree pleeha limfaivaji rakt peshi filter karate. tonsilna kadhikadhi chukine lasika granthi mhanoon sambodhale jaate. tonsils aanee lymph nodes jaree kahee vaishishtye samayik karat asale taree, tyanchyat tyanche sthan, rachana aanee aakar yasarkhe anek mahattvache farak dekhil aahet. yavyatirikt, tonsils uutinchya drawala filter karatat tarr lymph nodes lymphla filter karatat.
aantrapuchhamadhye lasika ootee asatat aanee mhanunach keval pachanvyavasthetach navhe tarr rogpratikarak vyavasthetahi bhoomika bajavate asey manale jaate.