
obesogen

obesogen hii kahee rasayanik sanyuge aahet jee samanya vikas aanee lipid chayapachay santulan bighadavanyasathi gruheet dharali jaatat, jyamule kahee prakarananmadhye laththapana yeu shakato. medjanya homeostasis aanee charbi sathavan ayogyaritya badalanari, chayapachayatil bindu badalanari, urja santulan bighadavanari kinwa charbi sathavane aanee laththapana vadhavanyasathi bhook aanee truptichya niyamanat badal karnari rasayne mhanoon obesogenschi karyatmak vyakhya kelee jaau shakate.
anek vegvegalya prastavit yantrana aahet jyadvare obesogen sharirachya charbiyukt uutinchya jivashastrat hastakshep karoo shakatat. yaa yantrananmadhye chayapachay sanvedkanchya krutitil badal; laingik steroid sanshleshan, krutee kinwa vighatan yanche aniyamitkaran; bhook aanee truptichya niyamanasah urja santulanachya kendriya ektrikaranatil badal; aanee chayapachay sanch bindunche punerprogramming yancha samavesh hoto. yapaiki kahee prastavit marganmadhye anoo receptor karyache ayogya modulation samavisht aahe, jyamule sanyuganna antahsravi vighatan karnari rasayne mhanoon vargikrut kele jaau shakate, jee shariratil samprerakanchi nakkal karatat, antahsravi pranalidware rakhalya jaananya samanya homeostasismadhye badal karatat.
diethylstilbestrall, nivadak serotonin reptech inhibitors aanee thyzolidinadione yasarkhya aushadhanchya swarupat obesogenic rasayananchya jaanunbujun vaparamule aanee tributiltin, bisphenol aii, diethylhexylfthalate aanee perfluoroctanoate yasarkhya paryavaraniy obesogenchya nakalat samparkat aalyane sharirat obesogen aadhalale aahet.
obisogen haah shabd 2006 madhye california vidyapith, irvinchya felix grune aanee broos blumberg yanni tayar keela hota.
krutichi yantrana.
obesogenic aushadhe aanee rasayne sharirachya charbiyukt uutinchya jivashastrat vyatyay aanoo shakatat asey anek marg aahet. krutichya teen mukhya yantrananmadhye samavisht aaheh
chayapachay sanvedak.
januk jaalyanmadhye aadhalanaya pratilekhan niyamkanvar obesogenic aushadhe aanee rasayne laksh kendrit karatat, jeey intracellular lipid homeostasis aanee edipocytesvaril prasar aanee farak niyantrit karnyasathi karya karatat. peroxisome proliferator sakriy receptors (pparα, δ aanee γ) mhanoon olakhalya jaananya nuclear harmon receptorscha eka gut haah niyamakancha pramukh gut aahe. yaa samprerak receptorsna lipophilic samprerak, aaharatil medyukt aaml aanee tyanchya chayapachayasah vividh chayapachay legandschee jaaniv hote aanee yaa legandschya vegvegalya patalyanvar avalambun, shariratil lipid santulanatil badal santulit karnyat guntalelya janukanche pratilekhan niyantrit karate. chayapachay sanvedak aanee pratilekhan niyamak mhanoon sakriy aanee yogyaritya karya karnyasathi, pii. pii. aar. receptorsna 9-sis retinoic acid receptor (aar. ex. aar.) mhanoon olakhalya jaanarya dusarya receptors heterodymerise karane aavashyak aahe. aar. ex. aar. receptor heey swatah pii. pii. aar. receptorschya pudhe obesogenche dusare pramukh lakshya aahe.
pii. pii. aar. aii. receptor, jevha aar. ex. aar. saha guntagunticha hoto aanee lipidchya bandhanidware sakriy hoto, tevha peroxisomechya prasarala chalana dete jyamule fatty acid β-auxidation vadhate. padarth, asey zenobiotics jeey pii. pii. aar. aii. chey agonist mhanoon lakshya karatat aanee karya karatat, samanyatah lipidache ekoon siramche praman qamee karnyasathi karya karatat. yaulat, pii. pii. aar. jee. emm. receptor, jevha aar. ex. aar. saha guntagunticha hoto aanee fatty acid kinwa tyanchya derivativeschya bandhanadware sakriy hoto, tevha lipid biosynthesisla protsahan milate aanee fatty acid oxidationpeksha lipidschya sathavanukila pasanti dilee jaate. yavyatirikt, sakriyakaranamule preadepocytes bhinnatela aanee medyukt uutinmadhye messenkimal purvaj peshinche preadepocytesmadhye rupantaran honyas protsahan milate. pii. pii. aar. jee. emm./aar. ex. aar. sankulache agnivardhak mhanoon lakshya karnare aanee karya karnare padarth samanyatah lipidchya ekoon siramchya sandratela vadhavanyasathi karya karatat.
pii. pii. aar. jee. emm./aar. ex. aar. sankulala lakshya karnari obesogens chayapachay legandschee nakkal karatat aanee receptor sakriy karatat jyamule lipid sanchay vadhato jyamule tyanche obesogenic parinam spasht hotat. tathapi, pii. pii. aar. aii./aar. ex. aar. sankulala lakshya karananya obesogenschya babatit, jeey jevha uttejit hote tevha charbiche praman aanee sharirache vajan qamee karate, teey laththapanala kase protsahan detat yabaddal kahee spashtikarane aahet.
pii. pii. aar. chey legand binding pockets khoop mothe aanee anirdisht asatat, jyamule receptorchya vegvegalya isophormsna (pii. pii. aar. aii., δ aanee γ) samaan agonist legands kinwa tyanchya chayapachayadvare sakriy karata yete. yavyatirikt, pii. pii. aar. aii. dware uttejit fatty acid oxidationsathi satat uttejana aavashyak asate, tarr edipocyteche antar aanee sankhya kayamswarupi vadhavanyasathi pii. pii. aar. jee. emm. chee keval ekach sakriyan ghatana aavashyak asate. tyamule, asey houu shakate qee obesogenla lakshya karnare pii. pii. aar. aii. chey chayapachay dekhil pii. pii. aar. jee. emm. sakriy karat aahet, jeey sambhavyatah pro-edipogenic pratisadakade nenyasathi aavashyak asaleli ekach sakriyan ghatana pradan karate.
dusare spashtikaran vishisht pii. pii. aar. aii. lakshyakanna nirdesh karate jeey garbhachya vikasadarmyan sadar kelyavar vrushan steroidogenesische asamanya pratilekhan niyaman karnyas karanibhoot asalyache darshavile gele aahe. yaa asamanya niyamnamule shariratil androgenchi patali qamee hote, jee swatach obesogenic asate.
shevati, jarr vikasachya nirnayak kalat pii. pii. aar. aii. sakriyakaran jhaale, tarr parinami vikasit honanya garbhatil lipidchya ekagratet honari ghat hii garbhachya mendudware kuposhanachi olakh patate. yaa prakaranat, vikasit mendu sharirachya chayapachay niyantranat kayamswarupi badal karato, jyamule lipid sathavan aanee dekhbhaliche dirghakalin niyaman hote.
laingik steroidche niyaman.
seeks steroids samanyatah shariratil lipid santulan rakhanyat mahattvapoorn bhoomika bajavtat. vadhichya samprerkasarkhya itar peptide samprerkanchya madatine, teey upasthit asalelya lipid sathyanna sanghatit karoon insulin aanee courtisoldware madhyasthi kelelya lipid sanchayanaviruddha karya karatat. obesogenchya samparkat aalyane anekada androgen aanee istrogen laingik steroidchya patalimadhil gunottarat kamatarata kinwa badal hoto, jyamule lipid santulanachya yaa paddhatimadhye badal hoto, parinami vadhichya samprerkacha srav qamee hoto, hypocortisolemia (parisanchari courtisolchi qamee patali) aanee insulinchya prabhavanna vadhalela pratikar.
obesojenmule laingik steroidchya patalitil haah badal ughad jhalelya vyaktichya linganusar tasech samparkat yenyachya velenusar mothya pramanat badaloo shakato. jarr rasayne vikasachya mahattvachya khidkyanmadhye aanali gelee tarr praudhavasthechya nantar sansarg jhalyas tyaa prabhavasathi ekhadya vyaktichi asurakshitata khoop jaast asate. heey disun aale aahe qee, tyanchya navjat vikasachya kalat phytoestrogen aanee days yaa donhi prakarchya undaranchya samparkat aalelya maadee undaranmadhye obesogenic parinam disun yetat, kaaran jaree teey qamee vajanachya janmachya vajanasah janmala aale asale taree, jawaljawal nehmich laththapana, uchch leptinchi patali aanee glukojchya pratisadat badal hott asatat. phytoestrogen aanee days exposed narr under yaa doghanmadhye laththapana vikasit jhaala nahee aanee tyaeivaji, exposure pratisadat ling farkanchya bhoomikechi pushti karananya vadhiv exposures sharirache vajan qamee jhalyache disun aale. pudhil abhyasanmadhye manvi loksankhyetil lathth mahilanshi seeram bii. pii. aii. chya patalisathi sakaratmak sambandh disun aale aahet, tasech itar zenoestrogen sanyuge manavanvar yaa parinamanchi samantar bhoomika suchavatat.
urja kendriya santulan.
harmon receptors heey obesogenchya lakshyansathi sarvat spasht umedvar asale taree, sampoorn dainandin aadharavar sharirachya poshanvishayak badalanche santulan aanee niyaman karananya kendriya yantranankade durlaksh kele jaau shakat nahee. etch. pii. aii. aksh (hypothalamic-petutory-adrenal) bhook aanee urja homeostasis circuits niyantrit karnyat guntalela aahe, jeey mothya sankhyene monoaminorgic, peptidergic (neurotransmitter mhanoon samprerkancha vapar) aanee endocanabinoid signaldware madhyasthi karatat jeey pachak marg, charbiyukt ootee aanee menduchya aatoon yetat. heey asha prakarche sanket aahet jeey vajan badalanare parinam darshavina obesojensathi sambhavya lakshya pradan karatat.
neuroendocrine prabhav.
majjasansthesambandhi vikar laththapanacha samavesh asalelya chayapachay lakshansamuchchay vikasit honyachi sanvedansheelata vadhavu shakatat. majjasansthesambandhi vikar asalelya rugnanmadhye vartanukiche marg badalanyasathi vaparlya jaanarya anek neuroformaceuticals chayapachay badalanare dushparinam disun aale aahet jyamule obesogenic phenotype dekhil hotat. heey nishkarsh assa nishkarsh kadhanyache purave detat qee lipid sanchayanat vaadh hone heey paradeshi rasayanandware neurotransmitter receptorsna lakshya karnyamule houu shakate.
peptidergic samprerak.
bhook aanee urja santulan niyantrit karnare anek peptidergic samprerak marg-jase qee ghrelin, neuropeptide vaay aanee egauti-sambandhit peptide yancha samavesh asalele-nuclear receptor signalling marganmadhil badalambaddal visheshtah sanvedanshil aahet aanee mhanunach antahsravi vighatankartyanchya parichayadvare sahajpane badalale jaau shakatat. asha badalamule upasamarichya bhavna nirman houu shakatat aanee paripoornatechya bhavna qamee houu shakatat jyamule annache sevan vadhate aanee samadhan vatanyas asamarthata yete, heey donhi laththapanache vaishishtya aahe.
bii. pii. aii., nonilphenol aanee dehap yasarkhya kahee zenoestrogen serve asha prakare karya karatat, aine. pii. aay. abhivyakti badaltat aanee ughad undaranchya khanyachya vartanat lakshaniy badal karatat. yavyatirikt, trimethylatine (tii. emm. tii.), triathyltine (tett) aanee tributylatine (tii. bii. tii.) sanyuge yasarkhe organotins samaan marganni tyanche parinam karoo shakatat. tii. bii. tii. hypothalamusemadhil eromatejchya niyamanat sthanik patalivar vyatyay aanoo shakate, jyamule samprerkanprati etch. pii. aii. akshancha pratisad asamanya hoto. tii. emm. tii. samaan parantu adviteey paddhatine karya karate, suruvatila aine. pii. aay. aanee aine. pii. aay. 2 receptor abhivyakti prerit karate, jee nantar jakhmanmadhil neuronal degenerationdware pratikar kelee jaate jyamule sanket kshamata qamee hote.
aaharat vaadh hii bahudha sansarganantar hote, tarr vajan vadhanyamadhye sharirachya chayapachay binduchi dekhbhal dekhil samavisht asate. hii mahitee dilee tarr, heey lakshat ghene visheshtah mahatvache aahe qee yaa nirdharit bindunchya vikasadarmyan aanee prarambhik programming darmyancha sampark urvarit ayushyabhar atyant mahattvapoorn asoo shakato.
endocanabinoid signalling.
aadhi namood kelyapramane etch. pii. aii. akshatil petidergic samprerakanchi nakkal karnare paryavaraniy organotinschi eka vistrut shreni, yavyatirikt canabinoid pranalichya lipid sakriyakanchi nakkal karate aanee aii. emm. pii. keey. kriyakalap rokhate. canaboid signalling marganchya atisakriyatemule laththapanacha tras asalelyanmadhye endocananidechi patali jaast asate. hii uchch patalich lipid sakriyak nakkal vastavik rogashi jodana vadhalelya charbichya sathyanshi jawalun sambandhit asalyache aadhalun aale aahe.
chayapachay sanch bindunche programming.
hypothalamusemadhil pradesh, ekhadya vyakticha chayapachay bindu aanee chayapachay karyakshamta sthapit karananya pratisadanvar niyantran thevatat. heey pratisad anukool asatat kaaran teey vyaktichya garajenusar badaltat, vegvegalya urjechya garajenusar chayapachay karye vadhavun kinwa qamee karoon chayapachay bindu punarsanchayit karnyasathi nehmi kaam karatat. teey julavun ghetale gelyamule, varr namood kelelya yantranedvare samprerkandware lipid santulan badalale tarr teey santulan prapt karoo shakel ashee apeksha aahe. tathapi, obesogenic phenotype tikoon asalyane, assa nishkarsh kadhala jaau shakato qee hypothalamusche anukool pratisad ghatak heey obesogenche dekhil lakshya asoo shakatat.
janmapurvi sharirachi rachana khoop purvanirdharit asate aanee praudhatvamadhye badal kvachitach hotat. edipocyteschi sankhya vikasadarmyan vadhate aanee patharavar yete, jyanantar edipocytes bahutek hypertrophic vadhiparyant maryadit asatat aanee peshinchya sankhyet farsa badal hott nahee asey disate. heey somatotype badalanyatil adchanidware kinwa adhik sopya paddhatine ekhadya vishisht tappyapudhil vajan qamee karnyachya prayatnasah jaananya adchanidware darshavile jaate. 
jyot mandavkanmadhye samanyatah vaparale jaanare rasayan polybrominated diaphenyl eathers (pii. bii. dii. eae.) vareel eka vishisht abhyasane thyroid samprerak akshanchi karye badalanyat tyachi bhoomika spasht kelee. haah shodh adhik chintet takto kaaran garbhatil vikasadarmyan, jee dirghkal shareer vajan karyakramasathi vaparali jaate, matechya paryavaraniy sanketanchya ektrikaranat navjat thyroidchi sthitee mothee bhoomika bajavate.
pharmaceutical obesogens.
shariratil obesogen shodhane aanee parinami obesogenic parinam heey aushadhanchya swarupat obesogenic rasayananchya janivpurvak vaparamule dushparinam houu shakatat. heey pharmaceutical obesogens vividh lakshyandvare tyanche parinam darshavu shakatat.
chayapachay sanvedak.
thyzolidinadions (tzd), rosiglitazone aanee pioglitazone heey serve madhumehachya upcharasathi vaparale jaatat. hii aushadhe pii. pii. aar.-jee. emm. receptorche agonist mhanoon kaam karatat jyamule insulin sanvedanshil parinam hotat jyamule glycemic niyantran aanee seeram triglyceride patali sudharu shakate. madhumehachya rugnanvar upchar karnyat yaa rasayananche sakaratmak parinam houu shakatat, tarihi, yaa aushadhachya vaparamule paridhiy sooj yasarkhe avanchhit pii. pii. aar.-jee. emm. madhyasthiche dushparinam dekhil hotat, jyanantar dirghkal aushadh vaparlyas satat vajan vadhu shakate. heey dushparinam visheshtah madhumehachya 2 rugnanmadhye thalak aahet, haah rog joou charbiyukt uutinchya atisevanane hoto.
laingik steroidche niyaman.
diethylstillbestroll (days) heey eka krutrim istrogen aahe jeey ekada mahilanna garbhpat honyacha dhoka qamee karnyasathi, teey ughad jhalelya santatimadhye vikrutee nirman karat asalyache aadhalat nahee toparyant lihoon dile gele hote. navjat vikasadarmyan ughad jhalyavar maadee undaranmadhye vajan vadhanyas hetch rasayan karanibhoot asalyache disun aale aahe. jaree sansargamule janmachya velee asamanya vajan hott nasale taree praudhavasthet khoop nantar lakshaniy vajan vadhale.
urja santulanache kendriya ektrikaran.
nivadak serotonin punargrahan avarodhak (ess. ess. aar. aay.) (udaa.jee. paroxetin), tricyclic antidepressant (udaa.jee. emitriptillin), tetracyclic antidepressants (udaa.jee. mirtazapine) aanee asamanya manovikrutivirodhi (udaa.jee. closapine) hii serve neuropharmaceuticals aahet jee vartan niyantrit karananya menduchya paripathanshi sambandhit asalelya neurotransmitter receptorsna lakshya karatat. anekada yaa receptorsche karya chayapachay niyantranashi overlap hote, jase qee etch1 receptorche jeey sakriy jhalyavar aii. emm. pii. keey. kriyakalap qamee hote. parinami, yaa aushadhanchya vaparamule medyukt padarthanchya vadhiv sanchayasah dushparinam houu shakatat, jyamule laththapana yeu shakato.
chayapachay sanch.
ess. ess. aar. aay., tricyclic antidepressants aanee asamanya anticycotics karyamagil yantrana tyaa sarvanna chayapachay kendranmadhye badal karnyat sambhavya bhoomika bajavanyas anumati detat. tzd, visheshtah etch. pii. tii. akshatil niyamak karyashi jodale gele aahe, tathapi, aataparyant konatahi nirnayak purava nishchit keela gelela nahee aanee yaa gruhitkanchi pushti karnyasathi pudhil sanshodhanachi aavashyakta aahe.
paryavaraniy obesogens.
obesogenic aushadhanchya vaparadvare obesogencha janivpurvak sharirat pravesh keela jaau shakato, tarr organotins aanee zenobiotics sarkhya vatavaranat aadhalanaya obesogenchya rasayanik samparkatoon dekhil sampark houu shakato.
organotins.
tributiltin (tii. bii. tii.) aanee triphenyltine (tii. pii. tii.) heey organotine vargache sthayi sendriya pradushakanche (pops) vishisht sadasya atyant nivadak asatat aanee retinoid ex receptors (aar. ex. aar. α, β aanee γ) aanee pii. pii. aar. jee. emm. yaa donhiche atishay shaktishali agonist mhanoon kaam karatat. ekach velee donhi receptorsna lakshya karanyachi hii kshamata, ekal receptor sakriyatepeksha adhik prabhavi aahe, kaaran heterodimer sankulachya donhi ghatkandware dattak sanket madhyasthi karata yeu shakatat. hii atyant prabhavi sakriyakaran yantrana visheshtah vikasachya aanee prarambhik aayushyachya darmyan sampark jhalyas hanikarak, dirghakalin medjanya parinam nirman karoo shakate.
sagari dooshit virodhi rung, lakud utprerak, plasticisers, slimicides, audhyogik jaal pranalinmadhye aanee annavareel burshinashakanmadhye vaparale jaanare organotins (tiin-aadharit rasayne) alikadech sharirat aanale gele tevha obesogenic gunadharmanshi jodale gele aahet. yaa pramukh paryavaraniy strotanshi manvi sampark samanyatah dooshit sagari ann, krishi utpadane aanee pinyache paanee tasech plasticchya galatichya samparkat aalyane hoto.
manvi ootee aanee raktatil organoteinchi patali thet mojana abhyasanmadhye maryadit asali taree, heey nirdharit kele gele aahe qee samanya loksankhyechya eka bhagachi organotinechya samparkat yenyachi asurakshitata aar. ex. aar. ess. aar. aanee pii. pii. aar. jee. emm. receptors sakriy karnyasathi puresha uchch staravar khoop sambhavya aahe. plastic aanee shetichya dekhbhalisathi organotinscha jaast vapar tasech rasayananchi uchch aatmiyata yaa nishkarshala pushti dete.
europe aanee aashiyatil 1990 chya dashakachya uttaradhatil yakrutachya namunyanmadhye ekoon organoteinchya patalisathi anukrame sarasari 6 aanee 84 enji/jee ole doubluty hote, tarr nantarchya abhyasanmadhye aadhalale qee yuu. ess. madheel ekoon organotinechya raktatil namunyanchi patali sarasari sumare 21 enji/miilii hotee aanee tbtmadhe sumare 8 enji/miilii (~ 27 nm) hotee. europeey rakt namunyanchya aanakhi alikadil vishleshanat pramukh prajati 0.09 aanee 0.7 enji/miilii (~ 0.5-2 nm) yaa tii. bii. tii. peksha tii. pii. tii. asalyache aadhalun aale. tii. bii. tii. chee keval adhunmadhun mojmap matra aadhalali. heey parinam soochit karatat qee manavanshi organtinecha sampark, jaree anek vegvegalya loksankhyanmadhye aadhalala asala taree, organetinecha prakar aanee pradeshanusar sampark patalichya drushtine badaloo shakato.
itar zenobiotics.
vatavaranat aadhalanaya itar samanya zenobioticsmadhye pii. pii. aar. kriyakalap asalyache disun aale aahe, jyamule aniyamit chayapachay santulanala aanakhi dhoka nirman hoto. polly carbonate plastickmadhil bii. pii. aii., pii. vhee. see. plastic mauu karnyasathi vaparale jaanare fathlet plasticisers aanee grahakopayogi utpadananmadhye mothya pramanat vaparale jaanare surfactants aanee prushthbhagavaril vikarshak asalele vividh perfluoroalkil sanyuge (pii. eff. see.) heey serve sharirat aanale jaatat tevha sambhavyapane obesogenic asatat. visheshtah fathlets aanee pii. eff. see. heey eka kinwa adhik pii. pii. aar. sathee agonist mhanoon karya karatat asey aadhalun aale aahe, shivay, mehap sarkhya dii. etch. pii. chey chayapachay dekhil pii. pii. aar. jee. emm. sakriy karatat jyamule proedipogenic pratisad midato.
sarvajanik aarogyavar honare parinam.
antahsravi vighatan karnare kinwa "obesogens" varr sanshodhan ajunahi udayala yet asale taree, aataparyant sarvajanik aarogyavar honare parinam pramukhyane laththapana, madhumeh aanee hriday v raktavahinyasambandhi roganna vedhalele aahet.
laththapana hii eka mahamari bunley aahe, jee serve loksankhya gatansathi vadhat aahe. 1980 teey 2008 yaa kalat laththapanache praman praudhanmadhye duppat aanee mulanmadhye tippat jhaale aahe. yuu madhye.ess. keval, assa andaj lavala gela aahe qee sumare 10 kotee lock lathth aahet, paramparik vicharanni asey suchavale aahe qee keval aahar aanee vyayam heey laththapanasathi mukhya yogdan denare hote; tathapi, sadhyachya prayogik puravyanvarun asey disun yete qee obesogen heey kaaran asoo shakate.
laththapanamule madhumehasarkhe sambhavya durbal karnare junat rog houu shakatat aanee kahee paryavaraniy sampark kinwa obesogencha thet sambandh type II madhumeh melitusshee (tii2dm) jodala gela aahe.
dainandin jeevanat sambhavya obesogens.
panyachya batalyanpasun teey microwave karnyayogya popcornparyant aanee nonstick panpasoon teey shower padadyanparyant anek goshtinmadhye obesogen aadhalu shakatat. kamachya thikani, shalet aanee gharee lock darroj jaanunbujun aanee nakalat tyanchyashi sanvad sadhatat. teey aarogyasathi anavashyak aanee bahudha talhata yenyajoga sambhavya dhoka aahet, jyacha vyakti vajan kase vadhavtat aanee qamee karatat yavar motha parinam houu shakato.
bisphenol-aii (bii. pii. aii.) heey eka audhyogik rasayanik aanee sendriya sanyug aahe jeey ardhya shatkapeksha jaast kalapasoon plastic aanee ralanchya utpadanat vaparale jaat aahe. khelani, vaidyakeey upkarane, plasticche ann aanee peye container, showerche padade, dant mudrank aanee sanyuge aanee nondani pavtya yasarkhya utpadananmadhye yacha vapar keela jaato. bii. pii. aii. keval containermadhun tayar keleli utpadane hataloon ann strotanmadhye kinwa sharirat shirate asey disun aale aahe. kahee sanshodhak asey suchavatat qee bii. pii. aii. mule shariratil charbi peshinchi sankhya qamee hote, parantu tyach velee urvarit peshincha aakar vadhato; tyamule, vajanat konatahi farak disun yet nahee aanee ekhadya vyaktichi vadhanyachi shakyata dekhil jaast asate.
nikotin heey tambakhoojanya padarth aanee kahee kitaknashakanmadhye aadhalanare rasayan aahe. obesogen mhanoon, nikotin heey bahutek vela matechya dhumrapananantar prasutipoorv vikasavar karya karate. mateche dhoomrapan aanee balpaniche jaast vajan/laththapana yanchyat eka majboot sambandh tayar karnyat aala aahe, jyamadhye nikotin haah ekmev karankarak ghatak aahe.
arsenic heey eka dhatuyukt padarth aahe ("i.eae.", kahee dhatuche gunadharm asalela ghatak) pruthvivaril bahutek naisargikaritya aadhalanaya padarthanmadhye aanee tyavar aadhalato. teey maatee, bhujal, havah aanee annamadhye qamee pramanat aadhalu shakate. kitakanashake, vanaushadhi, kitakanashake aanee electronic upkarananchya utpadanat aarsenikche anek upayog aahet. madhumehachya vikasacha sambandh pinyachya panyamule aanee vyavsayik samparkatoon honanya aarsenikchya samparkat yenyashi jodala gela aahe.
kitakanashake heey kitakanna rokhanyasathi, nasht karnyasathi, door karnyasathi kinwa qamee karnyasathi vaparale jaanare padarth aahet aanee teey serve nondavalelya itihasat vaparale gele aahet. kahee kitakanashake alp kalavadhisathi aanee kahee dirgh kalavadhisathi tikatat jee satat sendriya pradushak (pops) manali jaatat. anek cross-sectional abhyasanni kitakanashake heey laththapana, madhumeh aanee itar aajaranshi jodanare obesogen mhanoon darshavile aahet.
kahee aushadhopacharatmak aushadhe dekhil sambhavya obesogen aahet. 2005-2008 pasoon, 12 varshe aanee tyahoon adhik vayachya 11 takke american lokanni avasadavirodhi aushadhe ghetali. nivadak serotonin reptech inhibitors (ess. ess. aar. aay. ess.) mhanoon olakhali jaanari kahee avasadarodhi aushadhe, yuu. ess. madheel sumare 10 kotee lathth vyaktinmadhye sambhavyaritya bharr ghalat aahet.ess. ess. ess. aar. aay. antidepressantsche eka pramukh karya mhanje serotonin reptech transporterche (cert) niyaman karane jeey ann sevan aanee lipid sanchayanavar parinam karoo shakate jyamule laththapana yeto.
tributiltin (tii. bii. tii.) aanee triphenyltine (tii. pii. tii.) yasarkhe organotins heey antahsravi vighatan karnare aahet jeey edipocytesmadhye triglyceride sathavan vadhavtat asey disun aale aahe. jaree 1960 chya dashakapasun sagari udhyogat tyancha mothya pramanavar vapar keela jaat asala, taree manvi samparkachya itar samanya strotanmadhye dooshit sagari ann aanee shelfish, pikanvaril burshinashke aanee lakud upchar, audhyogik jaal pranali aanee vastrodyogat vaparale jaanare burshivirodhi ghatak yancha samavesh hoto. pii. vhee. see. plasticchya nirmitimadhye dekhil organotinscha vapar keela jaat aahe aanee pinyache paanee aanee ann purvathyat tyanchi olakh patali aahe.
perfluoroctanoic acid (pii. eff. oo. aii.) heey gharshan qamee karnyasathi vaparale jaanare eka surfactant aahe aanee teey nonstick paksamagrimadhyehi vaparale jaate. samanya americi loksankhyechya 98 takkyanhun adhik lokanchya raktat pii. eff. oo. aii. aadhalun aale aahe. haah eka sambhavya antahsravi vighatankarta aahe. pranyanchya abhyasatoon asey disun aale aahe qee pii. eff. oo. aii. chya prasutipoorv samparkat yene heey praudhatvaparyant pohochatana laththapanashi sambandhit aahe.
bhavishyatil sanshodhan.
sadhya olakhalya gelelya bahutek paryavaraniy obesogensache ektar sampoorn shariratil chayapachay samprerkanchya rasayanik nakkalinchya shreneet kinwa mendutil neurotransmittermadhye vargikaran kele jaate. teey yaa done shreninmadhye asalyamule, guntaguntichya parasparsanvadasathi aanee krutichi vividh thikane tasech anek aanvik uddishte vicharat ghenyasathi khulya aahet. badalatya matrechya shrenimule bhinn phenotype tayar hotat aanee sampark, ling aanee ling pravruttichi vel yaa padarthancha manvi shariravar kassa parinam hoto yaat aanakhi adhik patalichi guntagunt nirman hote.
kaaran obesogenchya vegvegalya parinamanmagil yantrana itaki guntaguntichi aahet aanee changlya prakare samajoon ghetali jaat naheet, sadhyachya laththapanachya sathichya aajarat teey kitee pramanat khelatat heey ekada vichar kelyapeksha jaast asoo shakate. obesogenchya samparkat yenyamule honare epigenetic badal dekhil eka shakyata mhanoon vicharat ghetale pahijet, kaaran teey chukichya niyaman kelelya chayapachay karyanchi kshamata pidhyanpidhya pudhe nenyachi shakyata ughadatat. niyamak pradeshanchya hypermethilationdware epigenetic prakriyanmule vividh prathinanchi atipradarshana houu shakate aanee tyamule, adhigrahit paryavaraniy parinamanche pravardhan houu shakate. yaa rasayananchya vaparachya prakriyechi adhik changli samaj midvanyasathi, sansarg honyacha dhoka kitee aahe heey tharvanyapurvi aanee pratibandh aanee vatavaranatun kadhoon taknyachya paddhati sthapit karnyapurvi sanshodhanachi aavashyakta asel.