
paraptosis

paraptosis (greek παρά "parra", "sambandhit" aanee apoptosis) haah eka prakarcha kramadeshit peshi mrutyu aahe, joou aakarshastriyadrushtya apoptosis aanee nekrosisapeksha vegala aahe. caspage sakriyakaran aanee pratibandhapasun swatantra asalele cytoplasmic vaculation aanee apoptotic morphologycha abhav hii paraptosischi paribhashit vaishishtye aahet. paraptosismadhye apoptosischi anek vaishishtyapurn vaishishtye nasatat, jase qee puttle bleebing, chromatin condensation aanee nuclear fragmentation. apoptosis aanee itar prakarchya kramadeshit peshi mrutyunpramane, peshi swatachya mrutyula karanibhoot tharatat aanee januk abhivyakti aavashyak asate. heey necrosischya ulat aahe, joou peshila jhalelya dukhapatimule honara gair-kramadeshit peshi mrutyu aahe.
paraptosis kahee vikasatmak aanee neurodegenerative peshinchya mrutyunmadhye aadhalala aahe, tasech karkarogachya anek aushadhanmule prerit aahe.
peshi mrutyuvaril namkaran samiteene tyanchya 2018 chya punaravalokan lekhat paraptosisla peshi mrutyucha eka prakar mhanoon manyata dilee nahee. samiteene tyanchya 2012 chya punaravalokanat yaa shabdacha vapar spashtapane nakarla hota
itihas.
paraptosis' yaa shabdacha pahila vapar sabina sperandio aanee itaranni keela hota."2000 saalee yaa gatane 293 tii peshi aanee undaranchya bhrunatil fibroblastmadhil peshinchya mrutyula uttejan denyasathi manvi insulinsarkhya vadhicha ghatak 1 receptorcha (aay. jee. eff.-1aar.) vapar keela, aanee peshinchya mrutyuchya itar prakaranpeksha vegale farak pahile. tyanni 'paraptosis' haah shabd tayar keela, joou greek purvapad 'parra' pasoon aala aahe, jyacha arth bajula kinwa tyachyashi sambandhit aahe aanee 'apoptosis'.
peraptosis haah shabd prakashit karnara sperandio haah pahila hota, parantu paraptosischya gunadharmansah peshincha mrutyu honyachi hii pahili vel navhati. peshi mrutyuchya yaa prakaranche varnan karnyasathi 'cytoplasmic' aanee 'type 3 seela death' yasarkhya sandnya purvi vaparlya gelya hotya. heey prakar aakarshastriyadrushtya paraptosishi khoop samyapurn aahet aanee heey shakya aahe qee peshinchya mrutyuchi kahee udaharane, moolatah yapaiki eka prakar mhanoon varnan keleli, paraptosischya ghatana aahet.
aakarvidnyan.
paraptosis haah prakar III kramadeshit peshi mrutyucha eka prakar aahe jyamadhye vishisht apoptotic aanee necrotic vaishishtyanche adviteey sanyojan aahe. paraptosis heey anoo vikhandan, apoptotic bodyjchi nirmiti kinwa chromatin condensation nishchit pratyakshik darshavat nahee-heey serve apoptosismadhye disun yete. tyaeivaji, paraptosis haah kahisa adim peshi mrutyu marg darshavito, joou necrosishi tulana karata yeto, jyamadhye vaishishtyapurn cytoplasmic vacule nirmiti aanee usheera mitochondrial sooj aanee clumping yancha samavesh aahe. kalantarane riktasthananchi sankhya aanee aakar vadhato. akheris, vaculeche aakar parat naan yenyachya tappyavar pohochatat aanee peshi punarprapt karoo shakat nahee.
apoptosyspramanech, plazma membrain cytoplasmic (aateel) patrakatoon peshi prushthbhagavar kinwa bahya patrakamadhye phosphatidilserine sthanantar thalakpane dakhavun paraptotic peshi olakhanyasathi daag lavnyachya tantracha vapar keela jaau shakato.
paraptosischya aakarvidnyanatil badal heey majjasansthechya vikasadarmyan jhalelya aakarvidnyanvishayak badalansarkhech asatat.
pramukh sanrachanatmak punarrachana.
jawaljawal lagech, golakar peshi, peshidrav punarsanchayit karane aanee paraptosismadhun jaananya peshinche rikt hone yasarkhya pramukh sanrachanatmak punarrachana prakash sukshmadarshikedware pahilya jaau shakatat. mitochondria aanee endoplasmic reticulumchi sharirik vaadh hote. yaa soojalelya swarupache shrey antahkoshikiy aayan asantulan aanee shevati ausmotic licesla dile jaau shakate. ekada futalyavar, kann aanee padarth sodale jaatat, jyat khaleel goshtincha samavesh hotoh (1) uchch gatishilata gut bii-1 (etch. emm. jee. bii. 1) (2) ushma shock prathine aanee (3) itar vividh protease. heey padarth "dhokyache sanket" aahet aanee parinami jaljal hote.
rasta.
program kelelya peshi mrutyuche kahee namune dii novo protein sanshleshanavar avalambun asalyache dnyat asale taree, 293 tii peshinmadhye igfir-aaysidvare prerit paraptotic peshi mrutyu actinomycin dii aanee cycloheximide rokhala jaato, jyamule pratilekhan aanee anuvadavar avalambun rahane disun yete.
receptor staravar aay. jee. eff.-aay. aar. vaparoon mapke aanee jeey. aine. keey. yaa done sakaratmak signal transduction margandware paraptosischa samavesh madhyasthi karnyasathi nishchit keela gela aahe. asha prakare, yaa marganchya vishisht prathinanchya kinesesna pratibandhit karoon paraptosis rokhala jaau shakato.
aii. aay. pii. 1chaa endophilines honara parasparkriya (tyachya carboxyl-terminaldware) antahkoshikiy nirvat tayar karnyas pravrutt karoo shakato. aii. aay. pii. 1/elix heey paraptosische 'pahile vishisht avarodhak' asalyache nishchit karnyat aale.
naun-receptor tyrosine keynage see-ess. aar. see. chya atee sakriyatenantar manvi colorectal karkarogachya peshinmadhye paraptosisarkhya phenotypeche varnan kele gele aahe, jeey paraptosismadhye ess. aar. see.-signalingacha sambhavya sahbhag soochit karate.
itar peshi mrutyu marganpeksha farak.
293 tii peshinmadhye aay. jee. eff. aay. see. dware prerit peshincha mrutyu sambandhit caspage kriyakalapanshivay peshincha mrutyu darshavito. heey apoptosischya tulanet aahe, jyamadhye propoptotic prathine baxmule caspage sakriyakaran aanee peshi mrutyu hoto. yavyatirikt, sanshodhanat asey aadhalun aale qee caspage inhibitors (zwad.eff. emm. keey., pii. 53, baaf), ex-gunasutra-sanlagn avarodhak (ziap) aanee bii. see. ell.-ex. ell. (bii. see. ell.-2 kutumbatil) yanni aay. jee. eff. aay. see. dware prerit jhalyavar 293 tii peshinmadhil peshincha mrutyu rokhala nahee. tyamule, apoptosischya avarodhkanmule prabhavit naan honyamadhye, paraptosis haah apoptosispeksha (peshi mrutyu prakar 1) vegala asalyache nishkarsh kadhale gele.
apoptosismadhye, etch. emm. jee. bii. 1, eka chromatin prathine, kendrakat rakhoon thewali jaate jyamule apoptotic bodies tayar hotat, tarr paraptosismadhye etch. emm. jee. bii. 1 sodale jaate.
paraptosis aanee autophagic peshincha mrutyu (peshi mrutyu prakar 2) yanchyatil sarvat paribhashit farak (april 2014 paryant) mhanje paraptosischa autophagic peshinchya mrutyoot disana vaishishtyapurn autophagic vaculescha abhav. apekshepramane, autophagic peshi mrutyu avarodhak (udaharanarth, 3-methyladenine) paraptosis rokhanyat aprabhavi asatat.
proteom profile.
paraptosischya kalat peshinmadhye aakarshastriy aanee proteom donhi prakarche badal anubhavata yetat. paraptosischya darmyan sanrachanatmak, signal transduction aanee mitochondrial prathinanmadhye honare badal serve disun aale aahet.
sanrachanatmak prathine.
paraptosischya prakriyetoon jaananya peshinmadhyeh
signal transduction prathine.
paraptotic peshinmadhye pebap kinwa raff keynage inhibitor prathine (aar. keey. aay. pii.) qamee hotat, tyamule parinami pebap aanee/kinwa itar keynage inhibitorsche niyaman qamee hone heey mapke aanee jeey. aine. keey. marganmadhye sahbhag darshavate, kaaran qamee jhalele pebpe mapke aanee jeey. aine. keey. chya patalila peshi mrutyula pravrutt karnyasathi purese jamaa honyas anumati deil.
mitochondria prathine.
aii. tii. pii. synthes heey anek upaghatakanni banalele asate aanee mitochondriamadhye aadhalate. paraptosis hott asatana, pii20 madhye aii. tii. pii. synthes bii. ess.-subunitche uchch praman darshavile gele.
mitochondrial daag heey ughad karate qee varjit pratibandhit patali asalelya golakar paraptotic peshi mitochondrial jaalyachya punarrachanetun jaat asalyache disate.
paraptotic peshinni nishedhamadhye 3.4 putt vaadh darshavili. paraptotic uttejanasah sanyugman kartana nishedhatmak padarthachya vadhalelya patalimule peshicha mrutyu houu shakato joou caspage avarodhkadvare rokhala jaau shakat nahee.
sambhavya vaidyakeey mahatva.
karkarog.
anek karkarogvirodhi padarthanmule manvi karkarogachya peshinchya mothya shreneet paraptosis hoto asey disun aale aahe. yamadhye naisargik strotanpasun tasech dhatuchya sankulanpasun midavalelya anek sanyugancha samavesh aahe. apoptosis pratirodhak karkarogavar upchar karnyacha eka marg mhanoon karkarog sanshodhanasathi paraptosis heey dekhil eka swarasyapoorn kshetra aahe.
paclitaxel, samanyatah taxol yaa vyapari navane vitarit kele jaate, heey karkarogache aushadh aahe jeey stun aanee andashayachya karkarogachya upcharasathi vaparale jaate. uchch sandratemadhye (70 microne), eka abhyasat asey disun aale qee teey paraptosisarkhya peshinchya mrutyula pravrutt karate aanee apoptosis-pratirodhak karkaroganvar upchar karnyasathi eka mahattvachi yantrana asoo shakate.
paam telapasoon milananya ii jivansatvacha eka prakar asalelya γ-tokotriyanalmule bruhadantra karkarogachya peshinmadhye paraptosisarkhya peshincha mrutyu hoto, asey sanshodhakanni aadhalale aahe. paraptosisla pravrutt karnyabarobarach, γ-tocotrianolne doubleu. aine. tii. sanket marg dekhil dabla, joou arbud vikasat bhoomika bajavato. yaa done vaishishtyanche sanyojan bruhadantra karkarogavar upchar karnyasathi eka naveen yantrana pradan karoo shakate.
vafavalelya american jinseng arkamule "colorectal karkarogachya peshi prabhavipane nasht hotat" asey nondavale gele aahe. visheshtah, protopanaxadiol aar. jee. 3 aanee aar. etch. 2 chey vyutpann heey arkat aadhalanare pramukh gensenocides aahet. colorectal karkarogachya peshi reshanmadhye, etch. see. tii. 116, cytosolic vaculization aar. etch. 2 dware prerit kele gele aahe. yavyatirikt, aar. etch. 2-prerit vaculization heey meek1/2 vishisht avarodhak yuu0126, cycloheximide pratibandhit kele gele hote, asha prakare paraptosischya done vaishishtyapurn gunadharmanchi pushti hote, nakasha kinezdware sanket dete aanee aavashyak prathine anuvad. aar. etch. 2. heey rosechya patalit vaadh karnyas dekhil pravrutt karate, jeey aine. eff.-keey. bii. sanket marg sakriy karate, tarr aine. aii. see. kinwa catalesses rosela avarodhit kelyane aine. eff.-keey. bii. sanket sakriy honyapasoon pratibandh hoto aanee aar. etch. 2. dware prerit peshincha mrutyu aanakhi vadhato. heey aar. etch. 2. chaa antioxidant-vardhit karkarogvirodhi prabhav soochit karate.
magnolia officinalis' pasoon tayar jhalele 'honocheol' heey sanyug manvi leukemia peshinmadhye paraptosisla pravrutt karoo shakate. aine. bii. 4 peshi reshemadhye, paraptosis hii peshi mrutyuchi prathamik paddhat hotee. keey562 peshinmadhye, apoptosis hii prathamik yantrana hotee, jyat adhunmadhun paraptosis aadhalato. sanshodhakanni sangitale qee hyamule asey soochit hote qee leukemia peshincha mrutyu anek marganni houu shakato.
eka prayogat phosphine copper (i) complexamule endoplasmic reticulum taana nirman karoon bruhadantra karkarogachya peshinmadhye paraptosis jhaala. aii0 thyoxotriazole copper (2) complexes yaa aanakhi eka tambe sankulamule endoplasmic reticulum strace aanee cytoplasmic vaculizationdware etch. tii. 1080 fibrosarcoma peshinmadhye paraptosis jhaala. oxidised glutathionmadhye vaadh aanee proteosome kriyakalapanna pratibandh yasarkhya cytotoxic prabhavansah, aii0 neey caspage-3 chee kriya rokhali, jee apoptosisla pratibandhit karoo shakate aanee paraptosisdware peshi maroo shakate.
neurodegenerative peshincha mrutyu.
sastan arbud dabnara pii53 chee kriya hii pii53, pii44 chya samarupachya patalivar avalambun asate. pii44 chee atee-abhivyakti asalelya transgenic undaranchya prayogat, aay. jee. eff.-1aar. chey atee-sakriyakaran jhaale, jyamule vruddhatva aanee mrutyuche praman vadhale. undaranna menduchya smrutee nirmiti aanee punarpraptishi sambandhit bhagat majjatantuncha mrutyu dekhil anubhavala. heey aay. jee. eff.-1aar prerit neurodegeneration paraptosis aanee autophagic peshi mrutyu yaa donhimule jhaale hote. aay. jee. eff.-1aar. heey neurodegenerative rogansathi sanshodhanache eka mahattvache kshetra aahe, kaaran aay. jee. eff.-1aar. chya vadhalelya patalisah aay. jee. eff.-1aar. chya sanketanmadhil dosh alzheimerchya rugnanchya mendut aadhalale aahet.
itar udaharane.
paraptosisarkhya kramadeshit peshincha mrutyu vanaspati aanee proteest yaa donhimadhye disun aala aahe. vanaspatinchya peshinchya peshinchya bhintimule phagocytosisla pratibandh jhalyamule pranyanmadhye aadhalanaya apoptotic mrutyunsarkhe vanaspatimadhye hott nahee. tambakhuchya eka prayogat, peshinchya dii. aine. aii. madhye duheri strand break aananyasathi bleomycincha vapar keela gela. yamule nantar paraptosispramanech, lakshaniy vaculization aanee dii. aine. aii. vighatan aanee caspage avarodh nasatanahi peshincha kramadeshit peshi mrutyu jhaala. dunalila viridis yaa shaivalavaril abhyasane vegvegalya paryavaraniy uttejananvar avalambun, paraptosis aanee apoptosis anek prakarandware program kelelya peshincha mrutyu karanyachi proteestchee kshamata darshavili. yaa ghatakanchya sanyogamule asey anuman lavale gele aahe qee paraptosis haah jivanachya vividh prakaranmadhye sanrakshit kelela, kramadeshit peshi mrutyucha eka purvajancha prakar asoo shakato.