
nodular lymphocyte pramukh hodgkin lymphoma

nodular lymphocyte pramukh hodgkin lymphoma (aine. ell. eff. ell.) haah hodgkin lymphomacha haloohaloo vadhanara see. dii. 20 sakaratmak prakar aahe, joou rogpratikarak pranalichya bii peshincha karkarog aahe.
aine. ell. eff. ell. haah hodgkin lymphomacha eka asamanya up-prakar aahe, joou hodgkin lymphomacha 5-10% banato. see. dii. 20 positive lymphocyte pramukh peshinchya upasthitimule heey classic hodgkin lymphomapeksha vegale aahe, jyanna popcornsarkhe disana tyanchya polylobated kendrakanmule popcorn peshi mhanoon dekhil olakhale jaate.
vividh prakaranmadhil purvasuchanamadhye lahan parantu spasht farak aahet. lymphocyte pramukh etch. ell. haah eka asamanya upprakar aahe joou mothya popcorn-aakarachya aar. ess. see. saha misalalelya asankhya pratikriyashil lymphocytes aspasht gathindware banalela aahe. classic aar. ess. see. chya ulat, aine. ell. pii. ell. chya abhijat nasalelya popcorn aakarachya aar. ess. peshi see. dii. 15 aanee see. dii. 30 nakaratmak asatat tarr bii. peshi chinhak see. dii. 20 sathee sakaratmak asatat. anty-see. dii. 20 monoclonal antibody retooksimabcha vapar lymphocytechya pramukh hodgkin lymphomamadhye utsahavardhak parinamansah keela gela aahe.
bii. see. ell. 6 janukanchi punarrachana varanvar disun aalee aahe.
chinhe aanee lakshane.
buub chee lakshane asamanya aahet.
nidan.
aine. ell. eff. ell. chee vaishishtye shastriy hodgkin lymphoma (see. ell.) peksha vegali aahet. lymphocyte pravinya (ell. pii.) (popcorn) peshi bii peshi aanee itar pratikriyashil peshi (pramukhyane pratikriyashil tii peshi) asalelya gathimadhye antarbhut asatat. reed-sternberg aanee hodgkin (aar. ess. etch.) peshi kvachitach disatat aanee rogpratikarak histochemistry ghatak peshinvar eka vegala namuna darshavate; aar. ess. etch. peshi samanyatah see. dii. 15 aanee see. dii. 30 vyakt karatat, tarr ell. pii. peshinmadhye yaa chinhakanchi abhivyakti nasate, parantu see. dii. 20, see. dii. 22 aanee see. dii. 79aii. sarkhya bii. peshi chinhak vyakt karatat aanee samanya leukocyte pratijan see. dii. 45 dekhil vyakt karatat, jeey aar. ess. etch. peshinvar asamanya aahe. ell. pii. peshinmadhye qamee peshidravya asate aanee eka dumadalele kinwa bahuvidh kendrak pramukh, mukhytah besophilic kendrakasah asatat. immunohistochemistry vaparasah anek aakarshastriy aanee immunophenotypic vaishishtyancha tadnya pathology aadhava aavashyak aahe.
samanyatah paridhiy lasika granthimadhye aadhalanare arbud, jeey paliv pranyanchya scandware aanee seaty scandware shodhale jaau shakatat.
urber stagingcha vapar arbud aanee lakshananche vargikaran karnyasathi keela jaato. chauthya tappyatil rog atishay durmil aahe.
seeks.
aine. ell. eff. ell. chey nidan purushanchya varchasvat hote.
lavkar olakh.
nidan sahasa rogachya pragatichya suruvatichya tappyat hote.
vyavasthapan.
rugnansathi aine. see. see. aine. margdarshak tattvandvare pradan kelele upchar margdarshak upalabdh aahet, tarr karkarogshastratil aine. see. see. aine. vaidyakeey sarav margdarshak tattve vaidyansathi sandarbh pradan karatat. konatyahi prastavit upcharatmak dhoranat kiman tivra aanee dirghakalin visharipana asane aavashyak aahe.
savadh vaat pahane.
savadhgirine pratiksha karane (pahaa aanee pratiksha qaraa) mhanje konatyahi upcharavina kiman 3 mahinyancha nirikshan kalavadhi.
shastrakriyedvare vichhedan.
kahee prakarananmadhye, jase qee vadhichya suruvatichya tappyat nidan jhalelya mulanmadhye, lasika granthiche shastrakriyedvare chhatani nidan kartana kelee jaau shakate. eka abhyasat nidanaveli shastrakriya karoon lasika granthichya chhataninantar, najar aanee pratiksha karnyachya dhoranasah ardhyahun adhik prakarananmadhye sampoorn maafee kayam asalyache aadhalun aale.
kiranotsarg upchar.
abhyas asey soochit karatat qee kiranotsarg upcharpaddhati (redio upcharpaddhati) praudhanmadhye pragaticha dhoka qamee karoo shakate. eka abhyasat, kiranotsarg upcharpaddhatine upchar kelelya pahilya-tisya tappyatil rugnanmadhye 10 varshansathiche kaaran-vishisht astitva 98 takke asalyache disun aale aanee kiranotsarg upcharpaddhatishi sambandhit dusya durdhar rogacha vikas honyacha darr upcharadvare vadhavala gela nahee (10 varshannantar 1 takke). 2013 madhye aine. ell. pii. etch. ell. chya suruvatichya tappyatil rugnanchya mothya gatavar prakashit jhalelya abhyasane, rogachya suruvatichya tappyatil ekmev upchar mhanoon maryadit kshetra kiranotsarg upcharpaddhati vaparnyas pathimba darshavila. palat, mahamarishastra aanee antim parinam (drashta) karkarog nondani karyakramatil 1,162 aine. ell. pii. etch. ell. rugnanvar kelelya abhyasat, kiranotsarg upcharpaddhatine ekoon astitva aanee rog vishisht astitva sudharle.
immunotherapy.
immunotherapymadhye vaparnyasathiche eka udaharan mhanje retooksimab. aine. ell. eff. ell. chya upcharanmadhye retooksimabcha vishisht vapar hoto kaaran too see. dii. 20 prathinanviruddhcha chimerick monoclonal pratipinda aahe. abhyas asey soochit karatat qee retooksimab punha udbhavalelya kinwa apavartak rugnanmadhye aanee visheshtah pragat tappyat agra-reshevaril upcharanmadhye dekhil kshamata pradan karato. punha udbhavanyachya pravruttimule, 2 varshansathi darr 6 mahinyanni dekhbhal upchar suchavale jaatat. hystological parivartananantar retooksimab rugnache parinam sudharate asey disun aale aahe.
chemotherapy.
anthracyclineukt aaharasarkhya sambhavya paryayanmadhye aii. bii. vhee. dii., bcop aanee chop yancha samavesh hoto. mulanmadhye cop/aii. bii. vhee. chya chachanichya nikalanni asey suchavale qee kiranotsarg upcharpaddhatichya garjeshivay keval kemotherapyche sakaratmak parinam shakya aahet. ishtatam chemotherapy haah charchecha vishay aahe, udaharanarth, aii. bii. vhee. dii. aivaji aar-chops upcharansathi samarthanache purave aahet, parinam aii. bii. vhee. dii. kemotherapinantar 10 varshannantar punaravruttiche uchch darr (40 takke) darshavitat. bcopmadhye vishaktatecha dhoka jaast asalyache nondavale gele aahe.
ektrit upchar.
eka abhyasat sanyukt kiranotsarg upcharpaddhati (redio upcharpaddhati) aanee pratidravya retooksimabcha ahwal denyat aala. navyane nidan jhalelya usheera tappyatil rogamadhye aar-chop nantar vaikalpikpane kiranotsarg upcharpaddhatichi shifaras kelee jaate, tarr keval suruvatichya tappyatil rog redio upcharpaddhatisathi (jokhim ghatkanshivay tappa aay. aii.) kinwa kiranotsarg upcharpaddhatinantar (jokhim ghatkanshivay tappa aay. aii. vyatirikt itar prarambhik tappyanmadhye) sankshipt aii. bii. vhee. dii.-aadharit chemotherapycha sallah deela gela.
purvasoochana.
dirghakalin pathpurava aavashyak asalelya rogachya punaravruttichya pravrutti asoonahi, classic etch. ell. chya tulanet rognidan anukool aahe. classic etch. ell. chya tulanet punaravrutti tulanene usheera tappyat houu shakate. pragat-tappyatil pragati asalelya rugnansathi parinamababat maryadit mahitee aahe.
jaatiyata.
united statesmadhil eka abhyasane african american lokansathi chemotherapychya pratisadat ekoon jaganyat sudharana jhalyache suchavale aahe.
hystological parivartan.
mothya bii-seela lymphoma (dii. ell. bii. see. ell.) pasaravanyasathi hystologic parivartan 12 takke prakarananmadhye houu shakate. parivartananantar, neoplastic peshi monoclonal immunoglobulin januk punarrachana vahoon netat. uutakiy parivartanamule kharab purvasoochana houu shakate aanee tyamule punha ekada jhalyavar punaravrutti biopsy aavashyak aahe.
eka abhyasat 7.6 takke parivartan darr aadhalun aala aanee suchavale qee chemotherapychya aadhi sampark aanee pleeha sahbhagasah sadarikaran heey parivartanachya vadhiv jokhaminshi sambandhit hote.