
toupathy

toupathy hii neurodegenerative roganchya eka vargatil aahe, jyamadhye manvi mendut neurofibrillary kinwa glyophybrillary guntaguntinmadhye taau prathinanche ektrikaran hote. taau mhanoon olakhalya jaananya microtubule prathinanchya hyperfosphorylationdwar guntagunt tayar hote, jyamule prathine microtubulespasoon vegale hotat aanee aghulansheel samuchchay tayar karatat. (yaa ektrikarananna jodidar helical philaments dekhil mhanatat.) guntagunt nirman honyachi yantrana neat samajaleli nahee aanee guntagunt heey alzheimer rogache prathamik kaaran aahe qee paridhiy bhoomika bajavate heey adnyat aahe.
alzheimer rog.
alzheimer rog (aii. dii.) asalelya tyachya eka rugnanmadhye, neurofibrillary guntaguntiche varnan pratham elois alzheimerne kele hote. guntagunt hii duyyam toupathy manali jaate. vruddhatvachya falee asalyamule edche amyloidosis mhanoonahi vargikaran kele jaate.
jevha taau hyperphosphorylated hote, tevha prathine akshatantunmadhil sukshmanalikanpasun vighatit hotat. tyanantar, taau chukiche dumadalele hote aanee prathine ektrit houu lagatat, jyamule akheris alzheimerchya rugnanmadhye disanari neurofibrillary guntagunt tayar hote. jevha taau vegale kele jaate tevha sookshm nalikadekhil asthir hotat. neurofibrillary guntagunt aanee asthir sukshmanalikanchya sanyogamule akshatantunchya vahatukisarkhya prakriyanmadhye aanee majjatantunchya sanvadat vyatyay yeto.
jahiratinmadhye aine. eff. tii. chya sahbhagachi patali break tappyandvare paribhashit kelee jaate. break tappa I aanee II jevha aine. eff. tii. chaa sahbhag pramukhyane menduchya transantorinal pradeshapurata maryadit asato, tevha tappa III aanee IV jevha hippocampus sarkhya limbic pradeshancha dekhil samavesh asato aanee jevha vyapak neocortical sahbhag asato tevha v aanee vi vaparale jaatat. yacha budhepanavaril pattikachya sahbhagachya pramanashi gondhal houu naye, jee vegalya prakare pudhe jaate.
itar aajaar.
pikcha rog aanee corticobasal degeneration yaa donhimadhye, taau prathine soojalelya kinwa phugavalelya neuronsmadhye samaveshak shareer mhanoon jamaa hotat.
menduchya uutinchya sookshm tapasanivar, argirophilic dhanya rog (aii. jee. dii.) haah smrutibhranshatecha aanakhi eka prakar, argirophilic dhanye aanee gundallelya shariranchya mubalkatedware chinhankit keela jaato. kahijan yala alzheimer rogacha eka prakar manatat. heey progressive supernuclear palsie aanee corticobasal degeneration aanee pick rog yasarkhya itar toopathys saha-astitvat asoo shakate.
bahudha synuclean aanee taau prathine yanchyatil parasparsanvadamule, toupathy bahutekda cinuclinopathys aachchhadit hotat.
naun-alzheimerchya toopathiesche kadhikadhi frontotemporal dementia kinwa frontotemporal lobar degenerationshee asalelya sambandhamule 'pick complexes' mhanoon ekatra gatbaddh kele jaate.
sanshodhan.
asey aadhalun aale aahe qee canabinoid receptor prakar 1 (see. bii. 1) sakriy karane astroglial-vyutpann nitrick auxide (nahee) chya pratibandhat madhyasthi karate, jyacha vapar taau prathin hyperphosphorylation aanee alzheimer rogatil parinami sambandhit toupathyla (aii. dii.) blunt karnyasathi naveen sambhavya lakshya mhanoon keela jaau shakato.