
polyprolyn helics

polyprolyn helics haah prathinanchya duyyam sanrachanecha eka prakar aahe joou prathinanmadhye aadhalato jyat punaravrutti honanya prolin avasheshancha samavesh asato. davya hatachi polyprolyne II helics (pii. pii. aay. aay., polly-pro II) tayar hote jevha anukramik avashesh serve andaje (-75°, 150°) chya (φ, si) pathichya kanyachya dihedral konanna swikartat aanee tyanchya peptide bandhanche "trans" isomers asatat. hii pii. pii. aay. aay. rachana prolin vyatirikt itar amino acids prathine aanee polypeptidesmadhye dekhil samanya aahe. tyachpramane, adhik sankshipt ujavya hatachi polyprolyne aay helics (ppi, polly-proaay) tayar hote jevha anukramik avashesh serve andaje (-75°, 160°) chya (φ, si) pathichya kanyachya dihedral konanna swikartat aanee tyanchya peptide bandhanche "sis" isomers asatat. naisargikaritya aadhalanaya vees samanya amino acidpacky, keval proline peptide bandhatil "sis" isomer, visheshtah ex-pro peptide bandh swikaranyachi shakyata asate; steric aanee electronic ghatak itar bahutek peptide bandhanmadhye "trans" isomerla mothya pramanat anukool asatat. tathapi, prolinchi jaaga dusarya 'aine'-paryayi amino acidne (jase qee sarcosin) ghenare peptide bandh dekhil 'sis' isomer swikaranyachi shakyata aahe.
polyprolyn II helics.
pii. pii. aay. helixchi vyakhya andaje (-75°, 150°) aanee peptide bandhanchya "trans" isomerschya (φ, si) pathichya kanyachya dihedral konatoon kelee jaate. trans" isomers konatyahi polypeptide helixchya prati avashesh paribhraman coone ω samikaranadvare deela jaato.
yaa samikaranat bahupariman II (φ, si) dihedral konanchya badalamule jawaljawal agadi barobar ω =-120°, i milate.eae.ppii helics haah davya hatacha helics aahe (ω haah nakaratmak asalyane) jyamadhye prati valan teen avashesh (360°/120° = 3) asatat. prati avashesh vaadh andaje 3.1 aahe. hii rachana tantumay prathin kolejanmadhye swikarlelya tantumay prathinansarkhich aahe, jee pramukhyane prolin, hydroxyprolyne aanee glycine banaleli aahe. pii. pii. aay. aay. helices visheshtah ess. etch. 3 kshetranni bandhalele asatat; heey bandhan anek prathine-prathine parasparsanvadasathi aanee agadi ekach prathinachya kshetranmadhil parasparsanvadasathi dekhil mahatvache aahe. 
adhik samanya helical duyyam sanrachana, alfa helics aanee tyache sambandhit 310 helics aanee paee helics, tasech β-helixchya ulat, pii. pii. aay. helics tulanene ughada aahe aanee tyat antargat hydrogen bandh naheet. amide nitrogen aanee auxigen anoo khoop door aahet (andaje 3.8 Â) aanee hydrogen bandhanasathi chukichya dishene aahet. shivay, heey donhi anoo prolinemadhye etch-bandh "swikaranare" aahet; chakriy bajuchya sakhalimule etch-bandh daata nahee.
prolin vyatirikt itar amino esidsathi dekhil prathinanmadhye pii. pii. aay. aay. pathichya kanyachya dihedral coone (-75°, 150°) varanvar disun yetat. ramchandran bhukhandachi loksankhya pii. pii. aay. aay. pradeshat jaast aahe, jyachi tulana beeta sheetchya kshetrashi kelee jaau shakate (-135°, 135°). udaharanarth, pii. pii. aay. aay. pathichya kanyachya dihedral konanna anekada valyanmadhye pahile jaate, samanyatah prakar II-β-valanchya pahilya avasheshat. acciral amino acid glycinechya polymer vagalata, pathichya kanyachya dihedral konanmadhye (75°,-150°) 'mirror emage' kvachitach disatat. polly-glycinemadhil polly-pro II helixchya analogla polly-gly II helics mhanatat. hypogastrura harveichya antifries prathinansarkhya kahee prathinanmadhye glycineukt polyglycin II helisesache bundle asatat. yaa ullekhaneey prathinala, jyachi 3dii rachana dnyat aahe, tyat adviteey aine. emm. aar. varnapat aahe aanee teey dimerisation aanee 28 see. aii.-etch. oo. oo. = see. hydrogen bandhandware sthir kele jaate. transmembrane prathinanmadhye pii. pii. aay. helics samanya nahee aanee hii duyyam rachana naisargik paristhitit lipid patalanna paar karat nahee. 2018 madhye, germanytil sanshodhakanchya eka gatane visheshtah tayar kelelya krutrim peptidesne tayar kelelya pahilya transmembrane pii. pii. aay. aay. helixche bandhkam aanee prayogik nirikshan kele.
polyprolyn aay helics.
polly-pro aay helics heey tyachya peptide bandhanchya "sis" aaysomarsamule pii. pii. aay. aay. helikspeksha khoop daat asate. heey pii. pii. aay. aay. rachnepeksha dekhil durmil aahe kaaran "sis" aaysomarmadhye "trans" peksha urja jaast asate. tyache vaishishtyapurn dihedral coone (-75°, 160°) jawal aahet, parantu pii. pii. aay. aay. heliksasarkhe naheet. tathapi, pii. pii. aay. helics haah eka "ujavya hatacha" helics aahe aanee adhik ghatt jakhmesah, prati valan andaje 3.3 avasheshansah (3 aivaji) aahe. pii. pii. aay. heliksmadhil prati avashesh vaadh dekhil khoopach qamee aahe, andaje 1.9. punha, polly-pro aay heliksmadhye konatehi antargat hydrogen bandh naheet, donhi kaaran etch-bandh daata anoocha abhav aahe aanee kaaran emide nitrogen aanee auxigen anoo khoop door aahet (andaje punha 3.8) aanee chukichya dishene aahet.
sanrachanatmak gunadharm.
paramparikpane, pii. pii. aay. aay. tulanene kathor manale gele aahe aanee sanrachanatmak jivashastrat 'aanvik shasak' mhanoon vaparale gele aahe.jee., fret karyakshamta mojamapache mapan karnyasathi. tathapi, tyanantarchya prayogik aanee saiddhantik abhyasanni polyprolyne peptidechya yaa chitravar "kathor kathee" mhanoon prashnachinh upasthit kele aahe. terrahertz spectroscopy aanee ghanata karyatmak siddhant ganana vaparoon pudhil abhyasanni heey adhorekhit kele qee polyprolyn pratyakshat mool vicharapeksha khoopach qamee kathor aahe. x-pro "sis-trans" isomerisation ("eae" a ± 20 kcal/mol) uchch sakriyatechya urjemule polly-prolinechya pii. pii. aay. aay. aanee pii. pii. aay. helics prakaranmadhil paraspar rupantaran santh asate; tathapi, heey aantarparivartan prolil isomerases kinwa pii. pii. aay. aii. ess. mhanoon olakhalya jaananya vishisht isomeresesdware utprerit kele jaau shakate. pii. pii. aay. aay. aanee pii. pii. aay. helices yanchyatil aantarparivartanamadhye sampoorn peptide sakhalisah "sis-trans" peptide bandh isomerisation samavisht asate. aayan-gatishilata spectrometrivar aadharit abhyasatoon yaa prakriyedarmyan madhyavarti ghatakancha eka paribhashit sanch astitvat asalyache ughad jhaale.