
mallet-espartate shuttle

mallet-espartate shuttle (kadhikadhi fakt mallet shuttle) hii glycolysis darmyan tayar jhalelya electronche mitochondrianchya ardhpargamya aateel padadyamadhye yukaryotsmadhil oxidative phosphorylationsathy sthanantaranachi eka jaivarasayanik pranali aahe. heey electron aii. tii. pii. tayar karnyasathi qamee samatulya madhyamandvare mitochondria electron vahtook sakhalimadhye pravesh karatat. shuttle pranali aavashyak aahe kaaran mitochondrial aateel padada nadsathi abhedya aahe, joou electron vahtook sakhalichya prathamik qamee karnyachya samatulya aahe. yala talhanyasathi, mallet padadyavar qamee karnare samatulya vahoon netat.
ghatak.
shatalmadhye chaar prathinanche bhag asatatah
yantrana.
mallet-espartate shuttlemadhil prathamik enzyme mhanje mallet dehydrogenase. mallet dehydrogenase heey shuttle pranalimadhye done swarupat asateh mitochondrial mallet dehydrogenase aanee cytosolic mallet dehydrogenase. done mallet dehydrogenesses tyanchya sthan aanee sanrachanenusar bhinn asatat aanee yaa prakriyet tyanchya pratikriyanna viruddha dishene utprerit karatat.
pratham, cytosolmadhye, mallet dehydrogenase mallet aanee nadd + tayar karnyasathi oxaloacetate aanee nadchya pratikriyes utprerit karate. yaa prakriyet, nadhmadhun tayar honare done electron aanee sobat asalele etch +, oxaloacitatela jodalele asatat aanee tyamule mallet tayar hote.
ekada mallet tayar jhalyavar, pahila antiporter (mallet-alfa-catoglutarate) cytosolmadhun mallet mitochondrial matrixmadhye aayat karato aanee matrixmadhun alfa-catoglutarate ekach velee cytosolmadhye niryat karato. mallet mitochondrial matrixparyant pohochalyanantar, mitochondrial mallet dehydrogenejdware tyache oxaloacetetmadhye rupantar kele jaate, jyaa darmyan nadd + done electrons qamee karoon nadd tayar kele jaate. tyanantar mitochondrial espartate aminotransferesdware oxaloacitate espartatemadhye rupantar kele jaate (kaaran oxaloacitate cytosolmadhye vahoon nele jaau shakat nahee). espartate heey eka amino aaml asalyane, oxaloacetetmadhye amino radical jodane aavashyak aahe. heey glutametdware puravale jaate, jeey yaa prakriyet tyach enzymedware alfa-ketoglutaretmadhye rupantarit hote.
dusra antiporter (glutamate-espartate antiporter) cytosolmadhun matrixmadhye glutamate aayat karato aanee matrixmadhun cytosolmadhye espartate niryat karato. ekada cytosolmadhye, cytosolic espartate aminotransfarejdware espartate oxaloacetetmadhye rupantar hote.
mallet-espartate shuttlecha nivval parinam purnapane redox asatoh cytosolmadhil nadhche auksidikaran houn naad + hote aanee matrixmadhil naad + qamee houn naadh hote. cytosolmadhil nadd + nantar glycolysischya dusarya feridware punha qamee kele jaau shakate aanee matrixmadhil nadcha vapar electron vahtook sakhalimadhye electron pathvanyasathi keela jaau shakato jenekarun atpche sanshleshan kele jaau shakate.
mallet-espartate shuttle mitochondrial matrixchya aat nadhche punarutpadan karat asalyane, teey glycolysismadhye (3/naadh) tayar honanya aii. tii. pii. chee sankhya vadhavanyas saksham aahe, parinami glukojchya chayapachay jhalelya prati renu 38 aii. tii. pii. renuncha nivval laabh hoto. yachee tulana glycerol 3-phosphet shuttleshee qaraa, jeey phaid 2 tayar karnyasathi phaid + qamee karate, electron vahtook sakhalitil quinon poolala electron daan karate aanee glycolysismadhye utpann honanya prati nadd keval 2 attups tayar karnyas saksham aahe (parinami shevati prati glucose chayapachay 36 atpscha nivval laabh hoto). (heey aii. tii. pii. kramank prechemiosmotic aahet aanee michel aanee itar anekanchya kamanchya prakashat teey qamee kele pahijet. pratyek naadh keval 2.5 atps tayar karate aanee pratyek fadh2 keval 1.5 atps tayar karate. tyamule, prati glucose aii. tii. pii. 38 varoon 32 aanee 36 varoon 30 paryant qamee kele pahije. oxidative-phosphorylation darmyan ajaivik phosphet aananyasathi aavashyak asalele atirikt etch + dekhil 30 aanee 32 sankhyanmadhye yogdan dete).
niyam.
mallet-espartate shuttlechi kriya mallet dehydrogenase 1 (emm. dii. etch. 1) chya arginine methylationdware niyantrit kelee jaate. prathine arginine aine-methyltransferase carm 1 methylates aanee tyache dimerisation viskalit karoon emm. dii. etch. 1 pratibandhit karate, jeey mallet-espartate shuttle dadapate aanee swadupindachya karkarogachya peshinchya mitochondria shwasanala pratibandhit karate.