
manvi seeram albumin

manvi raktatil albumin heey manvi raktat aadhalanare albumin aahe. manvi rakt plazmamadhye heey sarvat mubalak pramanat asalele prathin aahe; teey seeram prathinanpaiki sumare ardhe asate. heey yakrutat tayar hote. too panyat virghalato aanee monomeric aahe.
albumin samprerak, medyukt aaml aanee itar sanyuge vahoon netat, ph buffer karatat aanee itar karyansah oncotic daab rakhatat.
yakrutat albuminche preprolbumin mhanoon sanshleshan kele jaate, jyamadhye aine-terminal peptide asate jeey khadbadit endoplasmic reticulummadhun navjat prathine sodanyapurvi kadhale jaate. proelbumin heey utpadan, tyaa badalyat, sravit albumin tayar karnyasathi golgi upkaranat vighatit kele jaate.
sirammadhil albuminchya sandratesathi sandarbh shreni andaje 35-50 jee/ell (3.5-5.0 jee/dl) aahe. tyache siramche ardhayushya andaje 21 divas aahe. tyache aanvik vastuman 66.5 kilo dactor aahe.
albuminsathiche januk heey locus 4q13.3 madheel gunasutra 4 varr sthit aahe aanee yaa janukatil utparivartananmule visangatiyukt prathine houu shakatat. manvi albumin januk heey 16,961 nucleotides aahe, jeey anumanit 'cap' sitepasoon pahilya polly (aaa) jodanyachya saitparyant lamb aahe. heey 15 exonmadhye vibhagale gele aahe jeey ekach adim kshetrachya tippat karoon udbhavale aahe asey manale jaanare 3 kshetranmadhye samamitiyapane thewale aahet.
manvi seeram albumin (etch. ess. aii.) heey 67 keey. dii. aii. chya sapeksh aanvik vajanasah panyat virghalanare atyant golakar monomeric plazma prathine aahe, jyat 585 amino acid avashesh, eka sulfhydryl gut aanee 17 diasulphide pool aahet. nanoparticulate vahakanmadhye, etch. ess. aii. nanoe kann heey aushadh udhyogat byanch kalapasoon laksh vedhanyache kendra rahile aahet kaaran tyanchi vividh aushadh renunshi bandhanyachi kshamata, sathavan darmyan aanee vivo vaparat mothee sthirata, visharipana aanee pratijanta nahee, jaivavighatanakshamta, punarutpadanakshamata, utpadan prakriyeche praman vadhavane aanee sodanyachya gunadharmanvar changle niyantran. yavyatirikt, albumin renuvar mothya sankhyene aushadh bandhanyachya thikananmule kann matrixmadhye lakshaniy pramanat aushadh samavisht kele jaau shakate.
mapan.
seeram albumin samanyatah bromocasol hiravya kinwa bromocasol jambhalya rangasarkhya rangala bandhalyavar shoshanmadhil badalachi nond karoon mojale jaate.
sandarbh shreni.
praudhanmadhye manvi seeram albuminchi samanya shreni (> 3 vaay.oo.) 3.5-5.0 jee/dl (35-50 jee/ell) aahe. teen varshanpeksha qamee vayachya mulansathi, samanya shreni adhik vyapak aahe, 2.9-5.5 jee/dl.
qamee albumin (hypoalbuminemia) heey yakrutacha rog, nephrotic syndrome, jaljal, prathine qamee karnari enteropathy, shoshan, kuposhan, usheera garbhadharana, kalakruti, anuvanshik badal aanee ghatakatemule houu shakate.
uchch albumin (hyperalbuminemia) jawaljawal nehmich nirjalikaranamule hote. retinolchya (aaa jivansatva) kamataratechya kahee prakarananmadhye, albuminchi patali uchch-samanya mulyanparyant vadhavali jaau shakate (udaa.jee., 4.9 gramm/dii. ell.) kaaran retinolmule peshinmadhye panyane sooj yete. (aaa jivansatva jaast pramanat vishari asanyalahi hetch kaaran aahe.)
hii sooj itar paristhitimbarobarach gambhir murum upcharansathi eka aushadh asalelya 13-sis retinoic acid (isotratinoin) chya upcharadarmyan dekhil udbhavate. prayogshaletil prayoganmadhye asey disun aale aahe qee serve-trans retinoic aaml manvi albuminche utpadan niyantrit karate.
pathology.
hypoalbuminemia.
hypoalbuminemia mhanje raktatil albuminchi patali qamee hone. heey khaleel karananmule houu shakateh
vaidyakeey aushadhanmadhye, hypoalbuminemia hrudayavikaracha zatka, shastrakriyenantarcha aajaar, covid-19 yasarkhya anek paristhitinmadhye uchch mrutyudarashi lakshaniy sambandh aahe.
hyperalbuminemia.
hyperalbuminemia mhanje raktatil albuminche vadhate praman. samanyatah hii sthitee nirjalikaranamule asate. hyperalbuminemia haah uchch prathinyukt aaharashi dekhil sambandhit aahe.
vaidyakeey vapar.
manvi albumin dravan (etch. ess. aii.) vaidyakeey vaparasathi, samanyatah 5-25% chya sandratevar upalabdh aahe.
manvi albumincha vapar anekada haravalelya dravachya jaagi keela jaato aanee aaghat, jaljal aanee shastrakriyechya rugnanmadhye raktache praman punarsanchayit karnyat madat hote. albuminche sevan (ksharyukt padarthanchya tulanet) hypovolemia asalelya lokanche kinwa jaljal kinwa hypoalbuminimiamule gambhir aajari asalelyanche pran vachavate yacha konatahi thos vaidyakeey purava nahee. gambhir aajari asalele lock aahet jyanna albumincha fayda houu shakato qee nahee heey dekhil mahit nahee. tyamule, cochrain sahyog shifaras karato qee clinical chachanyanvyatirikt tyacha vapar karoo naye.
dhwanik themb bashpibhavnat (edd. vhee.), albumincha vapar kadhikadhi surfactant mhanoon keela jaato. atake upcharpaddhatidvare karkarogavaril upchar mhanoon edd. prastavit kele gele aahe.
manvi seeram albumincha vapar mofat aushadh/agentshee jodoon aushadh/rasayanik vishaktata sambhavyaritya ulatanyasathi keela jaau shakato.
manvi albumincha vapar vighatit sirosisachya upcharanmadhye dekhil keela jaau shakato.
manvi seeram albumincha vapar durbalata nirdeshankacha ghatak mhanoon keela gela aahe.
glycation.
heey byanch kalapasoon dnyat aahe qee haemoglobin aanee seeram albumin sarkhya manvi rakt prathinanche mand gair-utsechak glycation houu shakate, pramukhyane licinechya (aanee kadhikadhi arginine) avasheshanchya ε-emino gatanmadhye aanee raktatil glucose renunmadhye (mailard pratikriya) skiff bases tayar jhalyamule. hii pratikriya antioxidant ghatakanchya upasthitit rokhali jaau shakate. hii pratikriya samanyapane houu shakate, taree madhumeh melitasmadhye glycoalbumine praman vadhalyache disun yete.
glycationmadhye seeram albumin prathinanchi jaivik rachana aanee karya badalanyachi kshamata asate.
shivay, glycationmule pragat glycation antim utpadane (vay) tayar houu shakatat, jyamule asamanya jaivik parinam hotat. vayatil sanchayamule uutinchya prathinanchya sanrachanet aanee karyanmadhye badal karoon, pesheey pratisadanna uttejan deuun, vay-prathinansathi vishisht receptorsdware aanee pratikriyashil auxigen madhyavarti tayar karoon uutinche nuksan hote. vay dekhil dii. aine. aii. saha pratikriya dete, jyamule utparivartan aanee dii. aine. aii. sankraman hote. prathine aanee karbodkanmadhe ushna prakriya kelyane elarjikaranamadhye mothe badal hotat. vay heey pratijanik asatat aanee shijavalelya kinwa sathavalelya padarthanmadhye aadhalanaya anek mahattvachya neoentigence pratinidhitva karatat. teey peshinmadhil nitrick oxidechya samanya utpadanat dekhil hastakshep karatat.
seeram albuminchya rachnet jaree anek lycine aanee arginine avashesh asale, taree tyapaiki phaar qamee glycation pratikriyemadhye bhag gheu shakatat.
auxidation.
bahutek shariratil dravpadarthanmadhye albumin heey pramukh prathine aahe, tyache see. aay. ess. 34 heey shariratil mukt thiolscha sarvat motha ansh darshavate. albumin sis34 thayol qamee aanee oxidised asha donhi swarupat astitvat aahe. nirogi tarun praudhanchya plazmamadhye, ekoon etch. ess. aii. chya 70-80% madhye qamee swarupat see. aay. ess. 34 chaa mukt sulfhydryl gut kinwa mercaptoalbumin (etch. ess. aii.-ess. etch.) asato. tathapi, oxidative tanadvare darshavilelya pathological avasthanmadhye aanee vruddhatvachya prakriyedarmyan, oxidised form kinwa naun-mercheptoalbumin (etch. aine. aii.), prabal houu shakate. albumin thayol heey radical hydroxyl (hydroxyl) saha pratikriya dete.oh), hydrogen peroxide (etch2oo2) aanee pratikriyashil nitrogen prajati peroxinitrite (onoo) mhanoon.), aanee see. aay. ess. 34 teey sulphanic acid derivative (etch. ess. aii.-sooe. etch.) madhye oxidization darshavile gele aahe, tyacha punarvapar mercepto-albuminmadhe keela jaau shakato; tathapi pratikriyashil prajatinchya uchch sandratemule sulphinic (etch. ess. aii.-sooe. 2. etch.) kinwa sulphonic acid (etch. ess. aii.-sooe. 3. etch.) madhye aparivartaniy auxidation hote jeey tyachya sanrachanevar parinam karate. pratikriyashil auxigen prajatinchi (aar. oo. ess.) upasthiti, aparivartaniy sanrachanatmak nukasanas pravrutt karoo shakate aanee prathinanchya kriyakalapanmadhye badal karoo shakate.
mutrapindadware nuksan.
nirogi mutrapindamadhye, albumincha aakar aanee nakaratmak vidyutbhar heey glomerulusmadhil utsarjanapasun tyala vagalatat. madhumehachya nephropathys kahee roganpramane heey nehmich hott nahee, jeey kadhikadhi aniyantrit kinwa dirghakalin madhumehachi guntagunt asoo shakate jyamadhye prathine glomerulus olandu shakatat. haravalelya albumincha shodh eka sadhya mootra chachanidware lavala jaau shakato. albuminchya haravalelya pramananusar, rugnache mutrapindache karya samanya asoo shakate, microalbuminuria kinwa albuminuria asoo shakate.
parasparsanvad.
manvi seeram albumin eff. see. jee. aar. tii. shhee sanvad sadhat asalyache disun aale aahe.
too adyap adnyat asalelya albondin (jee. pii. 60), jee. pii. 18/jee. pii. 30 chee eka vishisht jodee aanee austionectin, etch. aine. aar. aine. pii. ess., caleticulin, cubillin aanee megallin yasarkhya itar kahee prathinanshi dekhil parasparkriya karoo shakato.