sonoperation

sonoperation kinwa cellular sonication mhanje peshi plazma patalatil pargamyata vadhavanyasathi ultrasonic shrenitil dhvanicha vapar. heey tantra samanyatah aanvik jivashastra aanee vishanuvirahit januk upcharpaddhatimadhye vaparale jaate, jenekarun dii. aine. aii. sarkhya mothya renunna peshimadhye grahan karata yeil, jyala sankraman kinwa parivartan mhanatat. yaa mothya renunche vitaran vadhavanyasathi sonoperation sukshmabudgyanchya dhwanik pokalicha vapar karate. sadhya kahee bhinn gruhitkancha shodh ghetala jaat asatana, sonoperation-madhyasth puttle sthanantaranachi achook yantrana aspasht aahe. 
ootee sanwardhan peshinmadhye, visheshtah sastan pranyanchya peshinmadhye parkeey janukanchya praveshasathi sonopareshancha sakriy abhyas suru aahe. vivomadhye lakshit januk upcharpaddhatit vaparnyasathi sonopareshancha abhyas dekhil keela jaat aahe, vaidyakeey upcharanchya paristhitit jyamadhye rugnala sudharit dna dile jaate aanee ultrasonic transducer yaa sudharit dnala rugnachya sharirachya vishisht bhaganmadhye lakshya karoo shakato. yaa tantrachi jaivkriyashilata hii vidyutsanyojanasarkhich aahe aanee kahee prakarananmadhye tee vidyutsanyojanapeksha shreshth asalyache aadhalun yete. qamee varanvarta (<mhz) ultrasoundchya vistarit samparkat aalyane sampoorn peshi mrutyu (futane) hoto heey siddha jhaale aahe, tyamule heey tantra vapartana pesheey vyavharyatechahi hishob karane aavashyak aahe.
upkarane.
samarpit sonoparetardware sonoperation kele jaate. bench-top function generator aanee dhwanik pravardhakanna jodalelya sanukoolit-nirmit piezoelectric transducers dekhil sonoperation kele jaau shakate. kahee anuprayoganmadhye manak ultrasound vaidyakeey upkarane dekhil vaparali jaau shakatat.
sonopareshanmadhye vaparlya jaanarya dhvanishastrache mojmap yantrik nirdeshankachya drushtine soochibaddha kele aahe, jeey dabavar aadharit bigger-aushnik krutidvare nidanatmak ultrasoundchya samparkat aalyane pratikool jaivik parinam honyachi shakyata mojate.
micro bubble contrast agents.
ultrasoundcha dhwanik prabhav vadhavanyasathi samanyatah micro bubble contrast agentscha vapar contrast-vardhit ultrasound anuprayoganmadhye keela jaato. visheshtah sonopareshansathi, sukshmabudgyancha vapar aanvik upcharshastrache padada sthanantar lakshaniyaritya vadhavanyasathi keela jaato.
samanya vaishishtye.
aaj vaparale jaanare sukshmabudgya vayucha gabha aanee sabhovatalachya kavachane banalele aahet. yaa ghatakanchi rachana pradhanyachya bhautik aanee rasayanik gunadharmannusar badaloo shakate. sookshm babulache kavach lipids, galactose, albumin kinwa polymers tayar jhaale aahe. vayucha gabha havah kinwa nitrogen kinwa perfluorocarbonsarkhya judd vayunni banalela asoo shakato.
krutichi yantrana.
sookshm babool vayoo kormadhye tyanchya drav vatavaranachya tulanet uchch sankochanakshamta asate, jyamule teey dhwanik anuprayogala atyant pratisad detat. ultrasound uttejanamule, sookshm fugyancha vistar aanee aakunchan hote, jyala sthir pokalikaran mhanatat. jarr sukshmabindu peshi patlala jodalela asel, tarr ultrasound uttejanane nirman honare sukshmabindu dolan patlala dhakalu aanee odhoon gheuun puttle ughadu shakate. hii jalad dolann sukshmapravah navachya jawalchya dravachya pravahasathi dekhil jababdar asatat, jyamule sampoorn peshinchya loksankhyemadhye aanakhi sonoperation nirman pradan sabhovatalachya peshinvar dabav vadhato. micro bubble-vardhit sonoperationshi sambandhit manalya manalya bhautik yantrananna push, pull, microstreaming, translation aanee jetting asey sambodhale gele aahe.
puttle sthanantaran yantrana.
sonoperation darmyan renu koshikeey puttle adthale konatya yantranedvare paar karatat heey aspasht aahe. vividh siddhant astitvat aahet jeey sambhavyapane adthala pargamyata aanee aanvik vitaran spasht karoo shakatat. pramukh gruhitkanmadhye chhidra nirmiti, endocytosis aanee padadyachya jakhamancha samavesh hoto.
chhidranchi nirmiti.
ultrasound anuprayoganantar chhidra nirmitichi nond 1999 madhye eka abhyasat karnyat aalee hotee, jyat 255 kilohertzwar ultrasound anuprayoganantar peshi puttle khadde disun aale hote. nantar, dextran renunchya sonoperation madhyasthi sookshm injection asey darshavile qee padada pargamyata yantrana dextran renunchya aakaranusar bhinn asate. 3 teey 70 keey. dii. aii. paryantchya dextran renunchya sookshm injection kshanik chhidrandware cellular membrain olandale asalyache nondavale gele. yaulat, 155 aanee 500 keey. dii. aii. chey dextran renu pramukhyane putika-sarkhya sanrachananmadhye aadhalale, jeey bahudha endocytosischi yantrana darshavtat. puttle vartanatil yaa badalamule ultrasound amplitude aanee kalavadhinusar puttle futane aanee receiling vaishishtyanchi tapasani pradan itar abhyasanna chalana midali aahe.
endocytosis.
ultrasoundchya vividh pesheey pratikriya endocytosisdware aanvik grahan karanyachi yantrana darshavtat. yaa nirikshan kelelya pratikriyavadi ghatananmadhye aayan vinimay, hydrogen peroxide aanee peshi antakoshiy calcium ekagrata yancha samavesh hoto. sonopareshanmadhye endocytosischya bhoomikesathi puttle sambhavya aayan devanghevaniche nirikshan karnyasathi abhyasanni patch clamping tantracha vapar keela aahe. peshi aanee lagatchya sukshmabudgyanvar ultrasoundcha vapar kelyane lakshaniy peshi puttle hyperpolarisation tayar hote aanee pragatishil antakoshiy calcium vaadh hote, jeey sukshmabulanchya dolananna pratisad mhanoon calcium vahinya ughadanyacha parinam asalyache manale jaate. heey nishkarsh paramparik endocytosis marganmadhye marganmadhye clathryn-lepit khaddyanche calcium-madhyasth uncoating prerit pradan ultrasound anuprayogasathi aadhar mhanoon karya karatat. itar kamanmadhye nondavale gele qee sonopareshanmule hydrogen peroxide tayar jhaala, jee eka cellular pratikriya aahe jee endocytosishi sambandhit asalyache dekhil olakhale jaate.
patalavaril jakhama.
sonoperation-utpadit katarane shaktincha parinam mhanoon plazma patalamadhye yantrikaritya tayar jhalelya jakhama aadhalalya aahet. yaa jakhamanche swaroop dhwanik pokalichya pramananusar badaloo shakate, jyamule patalavar raktastrav honyapasoon teey twarit peshi lisisparyant peshinchya vartanachya varnapatala chalana milate. padadyachya jakhamanche parikshan pradan anek abhyasanmadhye, aii. tii. pii. aanee intracellular putke yanchya bharativar avalambun asaleli prakriya, receiling vartanache nirikshan kele aahe.
puttle punarsanchayit karane.
sonoperation-madhyasth puttle pargamyata nantar, peshi 'punarnirmit sonoperation' navachya ghatanedvare padadyachya ughadyanchi svayamchalitapane durusti karoo shakatat."padada punha bund karanyachi prakriya calciumvar avalambun asalyache disun aale aahe. haah gunadharm asey suchavu shakato qee puttle durusti prakriyet calciumchya peshi pravahala pratisad mhanoon peshichi sakriy durusti yantrana samavisht asate.
purv chikitsalayin abhyas.
inn vitro.
ultrasoundcha vapar karoon aanvik prasaracha ahwal denara pahila abhyas 1987 madheel inn vitro abhyas hota, jyamadhye sonopareshancha vapar karoon plasmid dnala sanvardhit mouse fibroblast peshinmadhye hastantarit karnyacha prayatna keela gela. gela pratijaivik pratikar pradan pradan yaa yashasvi plasmid dna sankramanamule shevati inn vitro abhyasat pudhe gele, jyane plasmid dna aanee vivomadhil siranachya sonoperation sankraman kshamateche sanket dile.
vivo madhye.
vivomadhye ultrasound madhyasthi aushadh vitaran pahilyanda 1991 madhye nondavale gele aanee sonopareshancha samavesh asalelya itar anek purv chikitsalayin abhyasanche anusaran kele gele aahe. stroke, karkarog, parkinson, alzheimer yasah vividh roganvar upchar karnyasathi upcharatmak aushadhe kinwa januke vitarit karnyasathi hii paddhat vaparali jaat aahe... sonopareshanchi purv chikitsalayin upayuktata mageel tumour kiranotsarg upcharandvare changlya prakare spasht kelee gelee aahe, jyat aayanikaran kiranotsarg ultrasound-madhyasthi sukshmabindu raktavahinyanchya vyatyaysah jodala jaato tevha 10 patihoon adhik pesheey naash nondavala gela aahe. prasutichya karyakshamatet jhaleli hii vaadh upcharatmak matret yogya pramanat ghat karnyas anumati deu shakate.

