neocarginostatin

neocarginostatin (aine. see. ess.) heey eka macromolecular chromoprotein anidine antitumer pratijaivik aahe jeey "streptomysis macromomycetics" dware stravale jaate.
tyat done bhag asatat, eka asthir chromophore (ujavikade darshavilele prathine nasalele aanvik ghatak) aanee eka 113 amino acid prathine, jyasobat chromophore ghatt aanee sahsanyojak nasalele uchch aakarshanane (keey. dii. ~ 10−10 meater) bandhalele asate. prathine nasalela ghatak haah eka atishay shaktishali dii. aine. aii.-hanikarak ghatak aahe; tathapi too atyant asthir aahe aanee prathinanchi bhoomika tyache sanrakshn karane aanee lakshya dii. aine. aii. paryant sodane hii aahe. peshinmadhye asalelya qamee qamee paristhitit epoxide ughadalyane bergmanchya chakranasathi anukool paristhiti nirman hote, jyamule benzine tayar hote, tyanantar dii. aine. aii. strand cheed hote. naisargik utpadananchya chromoprotein gatatil aanakhi eka mahattvacha sadasya mhanje cadersidine.
eka aushadh mhanoon heey sarvat shaktishali aahe aanee keval japanmadhyech yakrutachya karkarogaviruddha vaidyakiyadrushtya vaparale gele aahe. 
aine. see. ess. chromoforeche jaivasanshleshan.
neocarginostatinche jaivasanshleshan januk samoohatil kriyakalapanchya abhisaranadvare hote, jyamadhye done swatantra punaravrutti prakar i polycatide synthes (pii. keey. ess.) aanee deoxy sakhar jaivasanshleshit margancha samavesh hoto. pahila prakar aay pii. keey. ess. januk, aine. see. ess. eae., anidine bhagasathiche sanket. dusra prakar aay pii. keey. ess. januk, aine. see. ess. bii., naphthoic acid bhagasathiche sanket. yavyatirikt, aine. see. ess. see. janukancha eka samooh aine. see. ess. chromophorechya dioxiamino sakharechya sanshleshanasathi enzymeschya kodingsathi jababdar asato. jaivasanshleshan teen prathamik prathamik vibhagale jaau shakate, jyat teen moetigeche antim abhisaran aaheh
1. deoxyaminosugar bhagache sanshleshanh haah bhag aine. see. ess. see. 6 dware 'aine. see. ess. see.' navachya saat janukanchya samoohadvare encode kelelya enzymesdware keela jaato. yaa enzymeschi dii. aine. dii. pii.-dii.-manose syntheseshi samanata asalyane, asey prastavit kele gele aahe qee, sanshleshan dii. manose-1-phosphatepasoon suru hote. see-2 hydroxyl gut (-oh) shevati nasht jhalyamule, dii-glucose-1-phosphet asanyachi shakyata dekhil nakarta yet nahee. tathapi, atirikt abhyas asey soochit karatat qee, dii-manose-1-phosphet haah prarambhik bindu asanyachi shakyata jaast aahe.
2. naphthoic aaml bhagache sanshleshanh "aine. see. ess. bii.", "aine. see. ess. bii. 1", "aine. see. ess. bii. 2" aanee "aine. see. ess. bii. 3" heey naphthoic aaml bhagachya sanshleshanasathi jababdar asalele enzymes aahet. heey itar anidine naisargik utpadanansarkhech aahe, sugandhi bhagachya nirmitimadhye guntaleli januke hii type II pii. keey. ess. pranaliaivaji punaravrutti prakar I pii. keey. ess. aahet. phenol gatavaril methyl gut samdware jodala jaato.
3. anidian bhag aanee abhisari assembliche sanshleshanh anidian heey "aine. see. ess. eae."..................................................................................................................................................................................................................................... "aine. see. ess. eae. teey" aine. see. ess. eae. 11 "haah aanakhi eka punaravrutti prakar aay. pii. keey. aahe, tarr" aine. see. ess. eff. 1 "aanee" aine. see. ess. eff. 2 "madhye epoxide hydrolage kriyakalap aahe.
shevati, bandhkam khand ektrit paddhatine ekatra kele jaatat. aine. see. ess. 6 glycosyltranspherase, anidine coor aanee dii. aine. dii. pii.-deoxyaminosugar yanchyatil jodanila utprerit karate. naphthoil gut aine. see. ess. bii. 2 qoo. aii. legace yaa enzymedware endean koarashi jodala jaato. eka atirikt carbonate karyakshamta jodali gelee aahe, jee bahudha carbon dioxide (kinwa bicarbonate) pasoon udbhavate, tathapi, hii payari kharokharach utsechak aahe qee nahee heey nirdharit karane baakee aahe.

