ell-dopa

-dopa, jyala levodopa aanee-3,4-dihydroxyphenyline asehi mhanatat, heey eka amino aaml aahe jeey manavansah kahee vanaspati aanee pranyanchya samanya jivashastracha bhag mhanoon tayar kele jaate aanee vaparale jaate. manav, tasech-dopa vaparnare itar prani, amino acid-tyrosinechya jaivasanshleshanadvare teey tayar karatat. -dopamine, norpinephrine (noradrinaline) aanee epinephrine (adrenaline) yaa neurotransmittercha dopa haah purvavarti aahe, jyanna ektritpane catecholamines mhanoon olakhale jaate. shivay,-dopa swatach mendu aanee see. aine. ess. dware neurotrophic ghatak sodanyat madhyasthi karato. -dopa tayar keela jaau shakato aanee tyachya shuddha swarupat inn levodopa saha cycoactive aushadh mhanoon vikale jaate; vyapar navanmadhye cinemate, pharmacopa, etamate aanee stellevo yancha samavesh hoto. eka aushadh mhanoon, parkinson rog aanee dopamine-pratisadatmak dystonia vaidyakeey upcharanmadhye yacha vapar keela jaato.
-dopacha viruddha,-dopa asalela pratirup aahe. anek renunpramanech, manvi shareer yapaiki keval eka isomers (-dopa form) tayar karate. - dopachi ananciomeric shuddhata optical rotationche nirdharan karoon kinwa kieral patal-thurr chromatographidware vishleshan kelee jaau shakate.
vaidyakeey vapar.
-dopa snrakshak rakt-mendu adthala paar karato, tarr dopamine swatach karoo shakat nahee. asha prakare, parkinson rog, parkinsonvad, dopamine-pratisadatmak dystonia aanee parkinson-plus syndromechya upcharanmadhye dopaminechi sandrata vadhavanyasathi-dopacha vapar keela jaato. vividh prakarchya lakshanansathi upcharatmak parinamkarakta vegali asate. bradykinesia aanee kadakpana hii sarvat pratisadatmak lakshane aahet tarr kampane levodopa upcharpaddhatila qamee pratisad detat. bolann, gilanyache vikar, mudra asthirata aanee gothaleli chaal hii sarvat qamee pratisad denari lakshane aahet.
ekada-dopane madhyavarti majjasansthemadhye pravesh keela qee, sugandhit-emino acid decarboxylase yaa enzymedware tyache dopaminemadhe rupantar hote, jyala dope decarboxylase asehi mhanatat. yaa pratikriyemadhye pyridoxal phosphet (jivansatva bii 6) haah eka aavashyak sahghatak aahe aanee kadhikadhi-dopa sobat, sahasa pyridoxine swarupat deela jaau shakato. kaaran levodopa dopamine sanshleshanatil darr-maryadit karnari payari tyrosine hydroxylase yaa enzymela mage takte, tyrosynpecsha teey dopaminemadhe adhik sahajpane rupantarit hote, jeey samanyatah dopamine utpadanasathi naisargik purvavarti asate.
manavanmadhye,-dopache dopaminemadhe rupantaran keval madhyavarti majjasansthemadhyech hott nahee. paridhiy majjasansthetil peshi samaan karya karatat. asha prakare keval-dopa dilyas parighamadhye dekhil dopamineche sanket vadhatil. atee paridhiy dopamine sanket dene avanchhaniy aahe kaaran soul-dopadware honare tyache anek pratikool dushparinam disun yetat. yaa parinamanna talhanyasathi, dopamineche paridhiy sanshleshan rokhanyasathi, carbidopa (carbidopa asaleli aushadhe, ektar ektyane kinwa-dopachya sanyogane, lodosine (etton farma) cinemate (merc sharp aanee dohem limited), pharmacopa (jazz pharmaceuticals), etamate (yuu. see. bii.), syndopa aanee stelevo (orean corporation) kinwa bensarazide (sanyojan aushadhe madoper kinwa prolopa mhanoon branded aahet) mhanoon branded kelee jaatat, asha paridhiy dopasah (-dopasah) dopamineche paridhiy sanshleshan rokhanyasathi (-dopapasoon) dopamineche sanyojan karnyasathi (-dopasah), heey pramanit vaidyakeey paddhat aahe. tathapi, jevha vanaspatijanya ark mhanoon sevan kele jaate, udaharanarth "emm prurins" purak padarthanpasun, tevha paridhiy dope decarboxylase avarodhak upasthit nasato.
inbrija (purvi see. vhee. tii.-301 mhanoon olakhale jaanare) heey levodopache shvasadvare ghetalele choorn tayar karane aahe jeey sadhya carbidopa/levodopa ghet asalelya parkinson rogachya rugnanmadhye "auph episode" chya adhunmadhun upcharansathi soochit kele jaate. 21 december 2018 roji united stateschya ann aanee aushadh prashasanane yala manyata dilee aanee ekorda therapeuticsdware tyache vipanan kele jaate.
dii. dii. see. aay. shivay pyridoxine sahprashasana-dopache paridhiy decarboxylation itake vegwan karate qee teey-dopa prashasanache parinam nakarte, hii eka ghatana aahe jyamule aitihasikdrushtya motha gondhal nirman jhaala.
yavyatirikt, paridhiy dii. dii. see. aay. saha-prashasit-dopa, restless legg syndromechya alpakalin upcharansathi prabhavi aahe.
- dopachya prashasanamadhye disanara done prakarcha pratisad aaheh
jaivik bhoomika.
-tyrosine hydroxylase yaa enzymedware amino acid-tyrosynemadhun dopa tayar keela jaato. -dopa-tyrosine nakkal mhanoon kaam karoo shakate aanee ell-tyrosinechya jaagi sastan pranyanchya peshindware prathinanmadhye samavisht kelee jaau shakate, jyamule protease-pratirodhak aanee ektrit-pravan prathine "inn vitro" tayar hotat aanee dirghakalin-dopa prashasanasah neurotoxicitymadhye yogdan deu shakatat.
heey monoamine kinwa catecholamine neurotransmitter dopamine, norpinephrine (noradrinaline) aanee epinephrine (adrenaline) sathee dekhil purvavarti aahe. sugandhit-emino acid decarboxylase (aii. aii. dii. see.) dware-dopachya decarboxylationdware dopamine tayar hote.
-katekol-oo-methyl transferragedware 3-oo-methyldopa aanee nantar vanilactic aesidmadhye dopache thet chayapachay kele jaau shakate. haah chayapachay marg nirogi sharirat astitvat nahee, parantu parkinson rog asalelya rugnanmadhye kinwa aii. dii. see. enzymechi kamatarata asalelya rugnanchya durmil prakarananmadhye paridhiy-dopa dilyanantar too mahattvacha tharato.
-fenilalanin,-tyrosine aanee-dopa heey serve jaivik rangdravya melaninche purvavarti aahet. tyrosinase heey enzyme-dopache pratikriyashil madhyavarti dopquinonmadhye auxidation utprerit karate, jeey pudhe pratikriya dete, jyamule akheris melanine oligomers hotat. yavyatirikt, tyrosinase escorbic esidsarkhya qamee tulana ghatakachya upasthitit tyrosineche thet-dopa madhye rupantar karoo shakate.
sagari sanlagnata.
-dope heey sagari sagari prathinanchya nirmitimadhye eka pramukh sanyug aahe, jase qee masselmadhye aadhaltat. yaa prathinanchya jaal-pratikar aanee jalad upchar kshamatesathi heey jababdar asalyache manale jaate. -dooshit karnare polymerla sanvedanshil tharanshi jodoon prushthbhag dooshit honyapasoon rokhanyasathi dekhil dopyacha vapar keela jaau shakato. ell-dopachya bahumukhi rasayanshastracha vapar nanoe tantradnyanat keela jaau shakato. udaharanarth, dopasah swayam-ektrit peptides karyatmak nanostructure, chikat aanee jail tayar karatat asey aadhalun aale.
dushparinam aanee pratikool pratikriya.
- dopachya dushparinamadhye khaleel goshtincha samavesh asoo shakatoh
jaree anek pratikool parinam-dopashi sambandhit asale, taree visheshtah manasopacharat, tyat anticholinergics aanee dopamine receptor agonists sarkhya itar antiparkinsanian ghatakanpeksha qamee ghatak asatat.
parkinson rogachya upcharanmadhye dirghakalin-dopa prashasanache parinam adhik gambhir aahet, jyat khaleel goshtincha samavesh aaheh
atyant aavashyak hoiparyant-dopa matra shakya titkya maryadit karoon, heey dushparinam aanee pratikool pratikriya talhanyacha doctor prayatna karatat.
ell-dopacha dirghakalin vapar monoamine auxideschya madhyamatoon sanshleshit dopaminechya enzymatic adhahpatanadvare oxidative taana vadhavato jyamule neuronal nuksan aanee cytotoxicity hote. dopaminechya monoamine auxideschya netrutvakhalil chayapachayadarmyan pratikriyashil auxigen prajatinchya prajatinchya nirmitimule oxidative taana nirman hoto. fenton pratikriya aanee antakoshiy autoxidationdware stiritammadhil stiritammadhil + aayanchya samruddhimule teey pudhe tikate. vadhiv oxidationmule dii. aine. aii. madhye 8-oxoguenine tayar jhalyamule utparivartan houu shakate, jeey mitosischya darmyan adenosineshi jodanyas saksham aahe.
itihas.
2000 saalee nobel paritoshik paritoshik karyat, swedish shastradnya arvid carlson yanni 1950 chya dashakat pahilyanda dakhavun dile qee aushadh-prerit (resurpine) parkinsonian lakshane asalelya pranyanna-dopa dilyamule pranyanchya lakshananchi tivrata qamee jhaali. parkinson rog asalelya rugnanchya shavavichedan kelelya mendut dopaminechi patali mothya pramanat qamee jhalyache shodhun kadhalyanantar, neuroshastradnya walter berchemeyer yanchyabarobar ektritpane prakashit kelelya, 1960/61 oleh hornikiwiczmadhye, rugnanmadhye antahshira prashasit-dopache natyamay upcharatmak antiparkinson prabhav. george cotzias aanee tyachya tyachya, jyanni mothya pramanat tondawate vadhaleli matra vaparali, tyanantar hya upcharancha vistar manganese vishbadheparyant aanee nantar parkinsanvadaparyant keela, jyasathi tyanna 1969 chaa laskar puraskar midala. neurologist oliver boxes yanni tyanchya 1973 chya 'awakenings' yaa pustakat encephalitis lethergica asalelya manvi rugnanvaril yaa upcharache varnan kele aahe, jyavar 1990 madheel yach navachya chitrapatachi aadharit aahe. ell-dopachya upcharanmule parkinson rogachya rugnanmadhye jhalelya sudharanancha ahwal denara pahila abhyas 1968 madhye prakashit jhaala.
2001 madheel rasayanshastratil nobel paritoshik dekhil-dopashi sambandhit hoteh nobel samiteene puraskaracha eka chaturthansh bhag william ess. yanna deela. kierley utprerit hydrogenation pratikriyanvaril tyanchya kamasathi nolls, jyache sarvat ullekhaneey udaharan-dopachya sanshleshanasathi vaparale gele.
sanshodhan.
vayashi sambandhit mccular degeneration.
2015 madhye, dopa naan naan aanee naan naan rugnanmadhil vay-sambandhit mccular degeneration (aii. emm. dii.) ghatananchi tulana tulana purvalakshi vishleshanat asey aadhalun aale qee aushadhane aii. emm. dii. chya prarambhas sumare 8 varshe vilamb keela. lekhak sangatat qee koradya aanee olya emm. dii. yaa donhisathi lakshaniy parinam prapt jhaale.

