
sorbs 1

cap/ponsin prathine, jyala sorbin aanee ess. etch. 3 domain-yukt prathine 1 asehi mhanatat, hii eka prathine aahe jee manavanmadhye "sorbs 1" janukadware encode kelee jaate. haah peshi sanlagnata, vadhicha ghatak sanket aanee cytoskeletal nirmiti niyantrit karananya adaptor prathinanchya eka chhotya kutumbacha bhag aahe. heey pramukhyane hriday, hadanche snayu, yakrut, charbiyukt ootee aanee macrofagemadhye vyakt kele jaate; pattankit snayu uutinmadhye, teey coastemer sanrachananmadhye sthanbaddh kele jaate.
rachana.
cap/ponsin heey 81 keey. dii. aii. teey 142 keey. dii. aii. paryantchya terr paryayi-vibhajit samarupanpramane astitvat asoo shakatat. too eka adaptor prathine kutumbacha bhag aahe, jyapaiki argbp2 aanee vinexin dekhil eka bhag aahet. yaa prathinanmadhye sanrakshit sorbin homology (soho) kshetra aanee teen ess. etch. 3 kshetra asatat aanee cap/ponsin hriday, hadanche snayu, yakrut, charbiyukt ootee aanee macrofagemadhye vyakt kele jaate.
karya.
snayunmadhye, sankshepan upkaranachya jodanidarmyan phokal sanlagnatesarkhya samparkanmadhun paripakv costmere tayar karnyat topi/ponsin bhoomika bajavate, kaaran topi/ponsinchya atiprabhavamule samanya peshi-matricks sampark aakarvidnyanat vyatyay yeto. coxsackivirus sansargamule honanya vishanujanya myocarditischya undaranchya pratikrutimadhye, cap/ponsinne vishanuvirodhi prakar I interferonche utpadan sthir kele aanee teey apoptosis aanee cytotoxicitypasoon sanrakshanatmak hote. insulin-prerit phosphorylationla saksham karoon aanee see. bii. ell. laa flotilincha samavesh asalelya lipid raft signalling complexmadhye bharati karoon, insulin-uttejit signalling aanee glukojchya sevanache niyaman karnyache heey eka pramukh niyamak asalyache dekhil disun aale aahe. macrophage karyat tyachi bhoomika yaa nishkarshane prakashit jhaali qee, asthimajjamadhye 'sorbs 1'-kamatarata asalelya macrophage asalelya undaranmadhye, teey uchch charbiyukt aahar-prerit insulin pratirodhapasun sanrakshanatmak hote aanee qamee jaljal darshavate. snayu nasalelya peshinmadhye, teey peshincha prasar aanee kendra sanlagnata uladhal rokhate, kaaran tyachya sirna-madhyasthichya fatakacha parinam pack/meek/erk sakriyakaran aanee peshi sthalantarat vaadh hoto.
vaidyakeey mahatva.
hrudayavikarachya antim tappyatil rugnanmadhye topi/ponsinche niyaman qamee asalyache disun aale; yantrik utaravanukivar tyacha parinam punha prasthapit jhaala. sorbs 1" madheel ekach nucleotide bahurupata haah prakar 2 madhumeh aanee laththapanashi sambandhit asalyache aadhalun aale.
parasparsanvad.
sorbs 1 yachyashi sanvad sadhatana dakhavale gele aaheh