donatal

donetal heey eka sanyukt aushadh aahe jeey paridhiy anticholinergic/antispasmodic kriya aanee saumya shamak dravya pradan karnyasathi phenobarbitals ektrit vishisht nishchit gunottarat naisargik beladona alkalides pradan karate. netrapatal heey iris, ell. ell. see. dware concordia pharmaceuticalsasathi tayar kele jaate. heey golya aanee 5 miilii amrut mhanoon upalabdh aahe. sakriy ghatak khalilpramane soochibaddha kele aaheth phenobarbital (16.2 migra), hyosamimine sulfate (0.1037 migra), atropin sulfate (0.0194 migra) aanee scopolamine hydrobromide (0.0065 migra). nantarche done ghatak beladona sarkhya solanesi kutumbatil vanaspatinmadhye aadhaltat.
sanket.
national academy auph sciences-national research council aanee/kinwa itar mahitichya yaa aushadhachya punaravalokanachya aadhare, eff. dii. aii. neey khalilpramane sanketanche vargikaran kele aaheh 'sambhavyatah' prabhavih irritable bowell syndrome (irritable collan, spastic collan, mucus colitis) aanee tivra enterocolitischya upcharanmadhye sahayak upchar mhanoon vaparnyasathi. duodinal alsarchya upcharanmadhye sahayak upchar mhanoon dekhil upayukt tharoo shakate.
itihas.
beladona alkalides aanee phenobarbitalchya sanyogasah vaidyakeey sanshodhan.
gelya 70 varshant beladona alkalides aanee phenobarbitalchya vividh sanyojananvar vaidyakeey abhyas kele gele aahet. udaharanarth, stegman aanee itar. 93 rugnanmadhye jatharantravishayak lakshananvar 0.25 mii. gra. beladona alkalides aanee 50 mii. gra. phenobarbitalchya sanyojanache moolyankan kele. loksankhyemadhye aay. bii. ess. chya 33 rugnancha samavesh hota. 33 paiki athara rugnanni lakshananmadhye purn aaram nondavala aanee 13 rugnanni 24 tasanchya aat aanshik aaramasah yogya pratisad nondavala. keval 2 aay. bii. ess. rugnanni konatahi pratisad naan dilyachi nond kelee. karyatmak jee. aay. vikar asalelya rugnanmadhye (mhanje 0.40 milligram beladona alkalides aanee ~ 60 milligram phenobarbital (1 dhanya) chya satat utsarjanache eka lahan moolyankan kele gele.eae., jatharachi atisardrata, apasmruti, pyrosis, vayoo vedna aanee epigastric tras. ekoon, 25 paiki 23 rugnanni lakshananmadhye purn kinwa lakshaniy aaram nondavala. 27 mahinyant "karyatmak tras" yasah vividh jatharantriy tras asalelya 82 vaidyakeey sarav rugnanmadhye, hockney 0.25 mii. gra. beladona alkalides aanee 50 mii. gra. phenobarbital nirantar prakashan sutrikaranachya parinamachi dekhil tapasani kelee. ekoon 82 rugnanpaiki 33 rugnanmadhye 50-75% aanee 20 rugnanmadhye 75-100% sudharana nondavali gelee. ardhyahun adhik rugnanmadhye vedna aanee aatadyanchya savayinmadhye sudharana jhalyache vishisht ahwal hote.
beladona alkalides + phenobarbitalchya sarvat suruvatichya yadruchchik duheri-andh chikitsalayin chachanyanpaiki eka 1959 madhye litchstein aanee itaranni kelee hotee. yaa abhyasat, 15 mahinyanparyant placibochya viruddha phenobarbitalchya jodanisah anticholinergic sanyojanachya upcharpaddhatichi tapasani karnyasathi, asthir aatadi asalelya 75 rugnancha (jyanchi lakshane aay. bii. ess. chya sadhyachya nidanasarkhi kinwa vaishishtyapurn aahet) samavesh hota. yapaiki 20 rugnanvar placebone upchar karnyat aale, 43 rugnanvar 50 mii. gra. phenobarbitals 0.25 mii. gra. beladona alkalides upchar karnyat aale aanee 12 rugnanvar donhi upchar karnyat aale (jyaa rugnanna pratisad midala nahee tyanna switch therapy denyat aalee). keval beladona alkalides/phenobarbital prapt prapt, 75.6% neey serve shreninmadhye sarasari sudharana (2 + kinwa adhik changli) nondavali. keval placibo rugnanmadhye, fakt 29.8% neey lakshananmadhye sarasari sudharana nondavali. jevha sudharaneche vaidyakeey moolyankan kele gele, tevha 24 takke placibo rugnanchya tulanet 69 takke beladona alkalides/phenobarbital rugnanmadhye sudharana jhalyache nondavale gele. upcharpaddhati badalalelya 12 rugnansathi, asey aadhalun aale qee tyanna moolatah placebo denyat aala hota aanee upcharpaddhatikade valavanyat aale hote. placebover asatana, 11.1% rugnanmadhye sarasari sudharana nondavali gelee, tarr 55.5% neey upchar paddhatimadhye sarasari sudharana nondavali. lekhakanni nondavale qee placeboveril rugnanna twarit parinamasah pratisad thoda jalad hota. pudhe, tyanni nondavale qee atisar asalelya rugnanmadhye, 100% neey sudharana nondavali tarr baddhakoshthata asalelyanmadhye 53.2% neey sudharana nondavali. baddhakoshthata asalelya anek rugnanna tantumay aanee julabyukt padarthahi denyat aale. jyaa rugnanmadhye baddhakoshthata hii mukhya takrar hotee, tyaa rugnanmadhye teey pratisad denyat ayashasvi tharalyache lekhakanni nondavale. 
anek karyalayin-beladona alkalides edd prakaran malikanni dekhil sumare 1,000 rugnansathi chidkhor bruhadantra, itar karyatmak vikar aanee jathar/duodenalmadhye beladona alkalides aanee phenobarbital formulation prabhavavar sakaratmak parinam sadar kele.
janmadatri vaidyakeey sanshodhan.
aaa. etch. robbinsne 1940 chya dashakat donatol vikasit kele aanee vipanan suru kele. gelya kahee varshant visheshtah donatol formulations done abhyas kele gele aahet. stegman aanee kaminsky yanni peptic alsarchya rugnanmadhye 0.1296 milligram beladona alkalides + 16.2 milligram phenobarbital (donatol), rugnanchya upasamuhatil gatishilata aanee serve rugnanmadhye (aine = 176) chikitsalayin parinamanchya antisecratory prabhavachi tapasani kelee. aay. bii. ess. rugnanpaiki (aine = 66), 53 takke purush rugnanmadhye aanee 58 takke mahila rugnanmadhye sampoorn aaramasah changla pratisad aadhalala. 37 takke purush rugna aanee 34 takke mahila rugnanmadhye anshatah sudharana houn yogya pratisad disun aala. 10 takke purush aanee 8 takke mahila aay. bii. ess. rugnanmadhye konatahi pratisad aadhalala nahee. 8 takke lokanni tond korade asalyache nondavale, tarr kahee dushparinam nondavale gele. jyaa rugnanni tandrichi nond kelee (10 takke) tasech jyaa rugnane drushtidosh nondavala tyaa 1 rugnamadhye matra qamee karnyat aalee. anyatha, rachana changlya prakare sahan kelee gelee.
aapatkalin kholyanmadhye vaparlya jaanarya jee. aay. cocktelcha donatal haah dekhil eka samanya ghatak aahe. 1976 madhye, yu. ess. madheel 25 sarvat mothya pramanat vihit aushadhanpaiki donatal heey eka hote.ess. tevhapasoon teey teey virodhi aanee proton pump avarodhakanni visthapit kele aahe, jeey adhik prabhavi aahet aanee phenobarbitalchya anek pratikool parinamancha abhav aahe.
turner aanee itarandvare chaar aathvadyanche bahu-kendra, yadruchchik placebo-niyantrit chachani. donetal golya (hyosamimine sulfate-0.1037 migra; atropin sulfate-0.0194 migra; scopolamine hydrobromide-0.0065 migra aanee phenobarbital-16.2 migra) yanchi tulana keval beladona alkalideshy (hyosamimine sulfate-0.1037 migra; atropin sulfate-0.0194 migra; scopolamine hydrobromide-0.0065 migra), keval phenobarbital (16.2 migra) aanee placeboshy kelee jaate. 204 aay. bii. ess. rugnanchya upchar karnyachya uddeshane loksankhyeche moolyankan vedna (aakadi), ratri aanee divasa vedna tivra hone, aatadyanchya halchalinchi varanvarta aanee upcharanna pratisad mhanoon sudharaneche jaagtik moolyankan karoon karnyat aale. 1 divasanantar serve gatanna vedna sudharanyasathi mishra pratisad midala. 1 divasanantar, donetal golya aanee beladona alkalides ghetana divas aanee ratrichya vedanet lakshaniy sudharana tasech chikitsak jaagtik mulyankanat lakshaniy sudharana disun aalee, parantu phenobarbital gut dekhil divas aanee ratrichya vedanesathi sankhyikiyadrushtya changla hota aanee divasachya vedanesathi placebo gut. donatol golya golya mahilanna keval phenobarbitalchya tulanet divasache aathvade vedanarahit anubhav yenyachi shakyata 4 putt jaast hotee aanee beladona alkalideschya tulanet ratriche aathvade vedanarahit anubhavanyachi shakyata duppat hotee. abhyasachya shevati beladona alkalideschya tulanet keval phenobarbital gatane andaje 48 takke pratisad darasah vedanechya prakarat lakshaniy badal darshavila. donatol golya, beladona alkalides aanee placeboveril serve rugnanna beladona alkalides elinechya tulanet anukrame 39.5%, 52.3% aanee 40.4% yaa nistej vedanet lakshaniy nasalele (pii> 0.149) badal hote. donatol golyanchya tulanet phenobarbitalvar vedanarahit aathvadyansathi purushannihi adhik pratisad darshavila. serve gatanni aatadyanchya halchalinchya varanvartet sudharana darshavili.
eff. dii. aii. chee sthitee.
donetal haah deshi aushadh shrenicha bhag manla jaato aanee sadhya eff. dii. aii. dware adyap moolyamapan kelya kelya 14 aushadhanpaiki eka mhanoon soochibaddha aahe. donatal ® parinamkaraktebaddal eff. dii. aii. chya prashnanna uttar mhanoon, aaa. etch. robbins company. donetal golya (anda 86-676), capsule (anda 86-677) aanee amrut (anda 86-661) sathee sankshipt naveen aushadh arj dakhal kele. capsule tayar karane vagalata heey anda aajahi lagoo aahet aanee eff. dii. aii. neey donatol chya punaravalokanachya sthiteet badal kelela nahee kaaran tyachya sanketasathi sashart manyata denyat aalee aahe.
29 september 2011 roji eff. dii. aii. neey deshi shrenibabat naveen margadarshan jaaree kele. yamule konatyahi naveen deshi formulationla bajarat pravesh karnyas prabhavipane parvanagi midali nahee. eff. dii. aii. neey asehi mhatale aahe qee deshi aushadhanmadhye 'aurange book' madhye soochibaddha keleli konatihi upcharatmak samatulya aushadhe naheet. tyanchya upcharatmak samatulyatechya varnanat, eff. dii. aii. neey visheshtah donatol chaa ullekh keela aahe. tyamule, deshi aushadhansarakhich rachana asaleli bajarat upalabdh asaleli konatihi tathakathit generic aushadhe bekaydeshir aushadhe manali jaatat kaaran eff. dii. aii. neey tyanchi rachana kinwa upcharatmak samatulyatecha aadhava ghetala nahee.
garbhadharana, jaree phenobarbitalyukt asali taree, formulationmadhye asalelya beladona alkalayadsamule niyantrit padarthanchya kayadyatoon mukt aahe. 

