endothelial kramank

endothelial nose (enos), jyala nitrick auxide synthes 3 (aine. oo. ess. 3) kinwa constitutive nose (see. aine. oo. ess.) asehi mhanatat, heey eka enzyme aahe jeey manavanmadhye gunasutra 7 chya 7 kyu 35-7 35-7 pradeshat asalelya "aine. oo. ess. 3" janukadware encode kele jaate. heey enzyme teen isophormspacky eka aahe jeey nitrick auxide (nahee), eka lahan vayoo aanee lipophilic renu sanshleshit karate jeey anek jaivik prakriyanmadhye sahbhagi hotat. itar samarupanmadhye neuronal nitrick auxide synthes (aine. aine. oo. ess.), jeey menduchya vishisht neuronsmadhye rachnatmakpane vyakt kele jaate aanee inducible nitrick auxide synthes (aay. aine. oo. ess.), jyachi abhivyakti samanyatah dahak roganmadhye prerit hote, yancha samavesh hoto. 
lumenmadhye rakt parisancharan aanee raktavahinyanchya urvarit bhintimadhil parasparsanvadavar, raktavahinyanchya aateel prushthbhagavar astar asalelya sapat peshincha eka thurr asalelya raktavahinyanchya endotheliummadhe 'noow' chya nirmitisathi enos pramukhyane jababdar aahe. raktavahinyanmadhil endotheliummadhe enosdware utpadit kelele aine. oo. heey raktavahinyanche swaroop, peshi prasar, raktpesheey sanlagnata aanee platelet ektrikaran niyantrit karnyat mahattvapoorn bhoomika bajavate. tyamule, nirogi hriday v raktavahinyasambandhi pranalisathi karyatmak enos aavashyak aahe.
rachana aanee utprerak kriyakalap.
enos haah eka diamer aahe jyamadhye reductase domendware tayar kelele 134 kilodinche done samaan monomers asatat, jeey nicotinamide edenine dynucleotide phosphet (naduff), flavin mononucleotide (eff. emm. aine.) aanee flavin edenine dynucleotide (phaid) sathee bandhan sthale darshavtat aanee eka auxidase domain aahe, jeey heema gut, jast, cofactor tetrahydrobiopterine (bii. etch. 4) aanee thurr ell-aarjininsathi bandhan sthale darshavate. reductage kshetra auxidase kshetrashi calmoduline-binding kramane jodalele aahe.
raktavahinyanchya endotheliummadhe, ell-arginine aanee aanvik oxygenmadhun enosdware 'noow' sanshleshit kele jaate, jeey enoschya heema gatashi bandhale jaate, qamee kele jaate aanee shevati 'noow' aanee 'ell-citrullin' tayar karnyasathi 'ell-arginine' madhye samavisht kele jaate. enos karyakshamatene 'bii. etch. 4' nirman karnyasathi cofactorche bandhan aavashyak aahe. yaa sahghatakachya anupasthitit, enos diamerickpasoon monomeric swarupat badalato, asha prakare uncuple hoto. yaa rachnet, 'nahee' sanshlesh karnyaivaji, enos superoxide ionen tayar karato, joou hriday v raktavahinyasambandhi pranalivar hanikarak parinam karnara eka atyant pratikriyashil mukt mooldrav aahe.
karya.
hriday v raktavahinyasambandhi pranalimadhye anosche sanrakshanatmak karya asate, jyache shrey konatyahi utpadanas dile jaat nahee. raktavahinyanchya swaranche niyaman hii hriday v raktavahinyasambandhi pranalitil 'nahee' chya sarvat prasiddha bhoomikanpaiki eka aahe. ekada endothelial peshinmadhye tayar jhalyavar, raktavahinyanchya gulgulit snayu peshi patalanmadhye konatahi prasar hott nahee aanee vidravya gwanilet cyclays (ess. jee. see.) heey enzyme sakriy karate, jeey gwanosin triphosphate chakriy gwanosin monophosphatemadhe (see. jee. emm. pii.) rupantaran utprerit karate. see. jee. emm. pii., tyaa badalyat, prathine keynage jee (pii. keey. jee.) sakriy karate, jeey cellular lakshyanchya anek phosphorylationla protsahan dete, jyamule cellular see. aii. 2 + sandrata qamee hote aanee raktavahinyanchya shithilatela protsahan milate.
see. jee. emm. pii.-aadharit see. aii. 2 + pravah rokhoon kinwa arginage aanee ornithin decarboxylage kriyakalapanna thet pratibandhit karoon, dii. aine. aii. sanshleshanasathi aavashyak asalelya polymidechi nirmiti qamee karoon, antiproliferative prabhav padat nahee. naa chey antithrombotic prabhav dekhil aahet jeey platelet membrainmadhye tyacha prasar aanee ess. jee. see. sakriyatemule hotat, parinami platelet ektrikaran rokhale jaate. shivay, anoo ghatak kappa bii (aine. eff.-keey. bii.) laa pratibandhit karoon raktavahinyanchya endotheliumshi asalelya leukocytechya sanlagnatevar konatahi parinam hott nahee, jeey chemokins aanee sanlagn renunchya raktavahinyanchya endothelial abhivyaktila prerit karate.
yaa karyanvyatirikt, enosdware utpadit konatyahi padarthamadhye antioxidant gunadharm nasatat kaaran superoxide dismutage yaa antioxidant enzymechya abhivyaktimadhye konatihi-prerit vaadh naan jhalyane superoxide aayan nirmiti qamee hote, jeey superoxide aayanche hydrogen peroxidemadhye rupantaran utprerit karate. shivay, antioxidantschya gunadharmancha kahee bhag heema-oxygeness-aay aanee ferritin abhivyaktichya up-regulationla karanibhoot aahe, jeey raktavahinyanmadhil superoxide aayanchi sandrata qamee karate.
niyam.
anuvadatmak, anuvadottar aanee anuvadottar staravar asalelya anek paraspar jodalelya niyaman yantranandvare enos abhivyakti aanee kriyakalap kaljipurvak niyantrit kele jaatat. ess. pii. 1, ess. pii. 3, eae. tii. ess.-1, elph-1 aanee vaay. vaay. 1 sarkhya pratilekhan ghatakanche aine. oo. ess. 3 pravartkashi bandhan aanee dii. aine. aii. methylation heey pratilekhan niyantranachi eka mahattvachi yantrana darshavate. anulekhanantar, enos prathamik pratilekh, emm. aar. aine. aii. sthirata, upkoshikeey sthanikikaran aanee nucleocytoplicasemic vahatukichya badalandware niyantrit kele jaate. enoschya anuvadanantarchya badalanmadhye fatty acid assilation, prathine-prathine parasparkriya, thurr aanee saha-ghatak upalabdhata aanee phosphorylation praman yancha samavesh hoto. mahattvache mhanje, caviolashi myristoilation aanee palmitoyaleshandware enos jodala jaato, jeey collesterol aanee sphingolipidsne samruddha asalelya padadyavaril pocketsarkhe aakraman aahe. kevolela enos bandhalyane, kevolin-1 saha enoschya majboot aanee thet parasparsanvadamule enzyme nishkriy hote. calcium-sakriy calmoduline anosashi bandhane kevolin-1 visthapit karate aanee enos sakriy karate. tathapi, alikadil abhyasanni yaa gruhitkavar prashnachinh upasthit kele aahe qee cavolin-1 thet anosashi bandhale jaate, kaaran anosashi bandhanyasathi prastavit cavolin-1 prathinancha pradesh plazma patalatil sthanamule praveshyogya asoo shakat nahee. parinami, enos kriyakalap niyantrit karnyasathi kevolin-1 anosashi kassa sanvad sadhato yachee vishishtata adyap aspasht aahe. shivay, tyrosine, serine aanee threonin avasheshanvaril anek phosphorylation sthalandvare enos sakriyakaran gatishilpane niyantrit kele jaate.
vaidyakeey mahatva.
uchch raktadab, preaclempsia, madhumeh mellitus, laththapana, erectile disfunction aanee ardhashishi yasarkhya anek roganchya rogjananamadhye konatehi utpadan samavisht nasate. yaa sandarbhat, mothya sankhyene kelelya abhyasatoon asey disun aale aahe qee aine. oo. ess. 3 janukatil bahurupata yaa roganchya sanvedanshilatevar parinam karate.
aine. oo. ess. 3 heey jaree eka atyant bahuroopi januk asale, taree yaa janukatil teen anuvanshik bahurupikaranancha vyapak abhyas keela gela aaheh ekal nucleotide bahurupikaran (ess. aine. pii. ess.) jee.-786t> c (jethe "g."haah genomic badal darshavito, jyacha parinam code kelelya prathinanmadhye aanee badalat hoto), joou anukrame aine. oo. ess. 3 pravartak aanee exon 7 madhye sthit asato aanee intron 4 madhye 27 bii. pii. punaravrutti dware darshavilelya tandam punaravruttichi (vhee. aine. tii. aar.) chull sankhya. jee sathee see elil.-786 tii> see bahurupata, jyamule enos abhivyakti qamee hote aanee utpadan hott nahee, uchch raktadab, preclempsia, madhumehi nephropathy aanee retinopathy, ardhashishi aanee erectile disfunction vadhiv jokhamishi sambandhit hotee. aanee bahurupatesathi 'asp' elilchi upasthiti enos kriyakalap qamee karate aanee uchch raktadab, preclempsia, madhumeh mellitus, ardhashishi aanee erectile disfunction uchch sanvedanshilateshi sambandhit hotee. intron 4 madheel vhee. aine. tii. aar. enos abhivyaktivar aanee uchch raktadab, preclempsia, laththapana aanee madhumeh melituschi sanvedansheelata prabhavit karate. vadhatya puravyanmule rogancha sambandh aine. oo. ess. 3 haplotypeshy (dii. aine. aii. blockchya jawal asalelya eleelche sanyojan) jodala gela aahe. haah drushtikon aanuvanshik bahurupatechya eka eka karoon vishleshanapeksha adhik mahitipurn asoo shakato. ess. aine. pii. ess. jee. saha haplotype.-786 tii> see aanee aanee aanee intron 4 madheel vhee. aine. tii. aar. neey madhumehachya rugnanmadhye uchch raktadab, preclempsia aanee uchch raktadab honyachi shakyata prabhavit kelee.
aine. oo. ess. 3 prakar heey sanket naan naan aushadhanchya pratisadanvar dekhil parinam karoo shakatat, jase qee stattins, angiotensin-converting enzyme inhibitors (aci) aanee phosphodisteres prakar 5 (pde-5) inhibitors inhibitors. jee sathee see. see. genotype vahoon vahoon vishayanmadhye jaivupalabdhata vadhavanyasathi stattin upchar adhik prabhavi hote.-tii. tii. vahakanpeksha 786 tii.> see. bahurupata. uchch raktadab asalele rugna jee sathee tii. see./see. see. genotype aanee see. elil gheuun jaatat.-786t> c bahurupatemule essie enlaprilala adhik uchcharaktadabavirodhi pratisad disun aala. tyachpramane, erectile disfunction asalele rugna jee sathee see elil vahoon netat.-786t> c bahurupatemule pii. dii. eae.-5 avarodhak syldenaphilala adhik changle pratisad midale. ektritpane, heey abhyas asey suchavatat qee jee sathee bhinn elil/genotype vahoon vahoon vishayanmadhye stattins, essie aanee pii. dii. eae.-5 avarodhak kharab jhalele utpadan punarsanchayit karoo shakatat.-786t> c nos3 bahurupata, asha prakare hriday v raktavahinyasambandhi dhoka qamee hoto. aanuvanshik bahurupatechya vaiyaktikaritya vishleshanavyatirikt, ess. aine. pii. jee. saha haplotype.-786t> c aanee aanee aanee intron 4 madheel vhee. aine. tii. aar. heey erectile disfunction asalelya rugnanmadhye syldenafilchya pratisadanvar parinam karatat asey darshavile gele.

