
paak 4

serine/threonin-prathine keynage paak 4 heey eka enzyme aahe jeey manavanmadhye "paak 4" janukadware encode kele jaate.
paak 4 haah serine/threonine kinesesachya paak kutumbatil sahaa sadasyanpaiki eka aahe, jeey gut I (paak 1, paak 2 aanee paak 3) aanee gut II (paak 4, paak 6 aanee paak 5/7) madhye vibhagale gele aahet. pak4 heey peshiras aanee kendrakachya up-koshikeey kshetranmadhye sthanbaddh hote. paak4 cytoskeletonche nutanikaran, phenotypic signalling aanee januk abhivyakti niyantrit karate aanee dishatmak gatishilata, aakraman, metastasis aanee vaadh prabhavit karate. paak 1 pramanech, paak 4-signal-aadharit cellular karye dekhil karkarogasarkhya sharirik aanee rog prakriya donhiche niyaman karatat, kaaran paak 4 manvi karkarogamadhye mothya pramanat atiprabhavit aanee/kinwa atisanvedanshil asate.
shodh.
gut II paak sadasyacha sansthapak sadasya, paak 4 chey pratirupan kele gele aanee munn aii. neey tyachi olakh patavali. aanee 1998 madhye sahkari jurecate kakshanpasun tayar kelelya see. dii. aine. aii. granthalayatun pii. see. aar.-aadharit ranniticha vapar karat hote.
januk aanee vibhajit prakar.
gut I pakchya tulanet gut II pakmadhye qamee coding exon asatat, jeey pakchya done gatanmadhil sambhavya sanrachanatmak aanee karyatmak farak adhorekhit karatat. manvi paak 4 13 exons sumare 57-keey. bii. lambicha aahe. paak4 12 pratilekhe tayar karate jyapaiki 10 coding pratilekhanmadhye sumare 438 teey 591 amino aesidchya prathinancha code asanyachi shakyata vartavali jaate, tarr urvarit done pratilekhanmadhye sanketikta nasaleli asatat. manvi paak 4 chya ulat, murine paak 4 madhye chaar pratilekhe aahet-593 amino esidsathi done coding lamb polypeptides aanee done naun-coding aar. aine. aii. pratilekhe aahet.
prathinanche kshetra.
paak 4 chya mukhya kshetranmadhye, see-terminal pradeshatil keynage kshetra, pii 21-binding kshetra (pii. bii. dii.) aanee navyane paribhashit swayam-avarodhak kshetra (madat) kinwa madat-sarkhya seudosubstrate anukram (pii. ess.) kshetracha samavesh aahe.
niyam.
etch. jee. eff., pii. keey. dii., pii. keey. aii., see. dii. keey. 5. aar. pii. 3 aanee ess. etch. 3. aar. eff. 2. yasah varchya bajus sakriy karnare aanee sanketadvare pii. aii. keey. 4 kriyakalap uttejit keela jaato.
itar yantrananvyatirikt, pick 4 karye, limk 1-thra508, integreen β5-sair759/sair 762, pii120-katenin-sair288, superior cervical ganglia 10 (ess. see. jee. 10)-sair 50, jee. eae. eff.-etch1-sair 810 β-katenin-sair 675 aanee smad2-sair465 yasah tyachya prabhavi prathinanchya phosphorylationdware madhyasthi kelee jaatat.
pii. aii. keey. 4 aanee/kinwa pii. aii. keey. 4-aadharit sanket emm. tii. 1-emm. emm. pii. aanee pii. 57. keey. pii. 2. yasah janukeey lakshyanchya abhivyaktimadhye dekhil badal karatat.
avarodhak.
pii. eff.-3758309, ell. see. etch.-7749944, glucarubinone, keey. vaay.-04031, keey. vaay.-04045,1-phenanthryl-tetrahydroisoquino derivatives, (-)-beeta-hydrastine, inka1, jee. ell.-1196, jee. aine. eae.-2861 aanee miir-145, miir-433 aanee miir-126 sarkhya micrornaz yansarkhya rasayanik avarodhkandvare paak4 kriyakalap aanee abhivyakti pratibandhit asalyache disun aale aahe.
karya.
serine/threonin pii21-sakriy karananya kinesesachya kutumbatil paak prathinanmadhye paak1, paak2, paak3 aanee paak4 yancha samavesh hoto. paak prathine heey mahattvapoorn parinamkarak aahet jeey roow gtpacesna cytoskeleton punarrachana aanee anoo sanketanshi jodatat. teey lahan jee. tii. pii. bandhan prathine see. dii. see. 42 aanee racksathi lakshya mhanoon kaam karatat aanee vividh prakarchya jaivik kriyakalapanmadhye guntalele aahet. pii. aii. keey. 4 visheshtah see. dii. see. 42etch. ess. chya jee. tii. pii.-baddh swarupashi sanvad sadhate aanee nakasha kinesesachya jeey. aine. keey. kutumbala kamkuvatpane sakriy karate. paak4 haah philopodia nirmiticha madhyasth aahe aanee actin cytoskeletonchya punarrachanet bhoomika bajavu shakato. yaa janukasathi bhinn isophorms encoding karnare anek paryayi splies transcript prakar sapadale aahet. miir-24 dware anuvadatmak staravar paak 4 dadapalyache disun aale aahe.
paak4 tyachya farshi kriyakalapadware aanee/kinwa prabhavi tharanchya phosphorylationdware cellular prakriyanche niyaman karate, jeey tyaa badalyat, cellular phenotypic pratisadat ektrit honanya jaivarasayanik ghatananche eka cascade tayar karate. paak4-niyantrit pesheey prakriyanchya udaharananmadhye, actin aanee microtubule tantunchi gatishil punarrachana, anchorage-swatantra vaadh, philopodium nirmiti aanee peshi gatishilata yancha samavesh hoto.>
parasparsanvad.
paak 4 yachyashi sanvad sadhatana dakhavale gele aaheh