glutamateyukt prathine 3

glutamate-samruddha prathine 3, jyanna vaishishtyahin prathine parasparkriya asehi mhanatat, heey erich 3 janukadware encode kelele prathine aahe. "erich 3" laa manvi genomemadhil tyachya nakashavaril sthanavar aadharit "gunasutra 1 open reading frame 173 (" parasparkriya ")" asey naav denyat aale. tyachya encoded amino acid kramamadhye glutamate (eae) chya uchch samagricha parinam mhanoon nantar tyache naav badaloon 'eae-ritch 3' asey karnyat aale. erich 3 janukatil ekal-nucleotide bahurupata (ess. aine. pii.) hii plazma serotoninchya sandratesathi genome-wide association abhyasatil (jee. doubleu. ess.) eka "top" signal mhanoon olakhali gelee aahe, jee swatah pramukh nairashya vikar (emm. dii. dii.) rugnanmadhye nivadak serotonin reptech inhibitor (ess. ess. aar. aay.) pratisadashi sambandhit hotee. starr * dii, aay. ess. pii. see. aanee predicts teen swatantra emm. dii. dii. chachanyanmadhye ess. ess. aar. aay. upchar parinamanshi lakshaniyaritya sambandhit asalela toch "erich 3" ess. aine. pii. nantar pradarshit karnyat aala. jee. tii. eae. ex. aar. aine. aii.-seque. mahitivar aadharit nucleus akumbens (besal ganglia) aanee frontal cortexs manvi menduchya vividh bhaganmadhye erich 3 sarvat jaast vyakt hote. manvi menduchya namunyansathichya ekal-peshi aar. aine. aii.-seek detavarun asey disun aale aahe qee erich 3 pramukhyane itar see. aine. ess. peshinchya prakaranaivaji neuronsmadhye vyakt kele jaate. erich 3 heey putika jaivjananatil prathinanchya karyashi parasparkriya karate aanee serotonergic aanee itar neuronal peshinchya prakaranmadhye putika karyat mahattvapoorn bhoomika bajavu shakate, jeey antidepressant upchar pratisadasah tyacha sambandh spasht karnyat madat karoo shakate. proteomic abhyasanchya aadhare raktatil platelets aanee siliyamadhye dekhil erich 3 prathine mubalak pramanat aadhalali. plateletmadhil tyache karya plazma serotonin sathavanukishi sambandhit asalyache manale gele kaaran 99 takkyanhun adhik rakt serotonin plateletmadhye sathavale gele hote aanee erich 3 snapes emm. dii. dii. rugnanmadhye plazma serotoninchya ekagrateshi sambandhit aahe. prathamik siliyamadhye erich 3 siliyam nirmiti aanee ciliary vahatukichya sthanikikaranas niyantrit karoo shakate.
januk.
manavanmadhil manavanmadhil januk 105,628 ksharanche aahe aanee gunasutra 1 chya lahan bahuvar 31.1 vya sthanavar vaja strandver aadhar jodee 75,033,795 bii. pii. pasoon 75,139,422 bii. pii. paryant pii. tii. aar. pasoon encode kele jaate. sandarbh aar. aine. aii. pramukhyane jee. tii. eae. ex. aar. aine. aii.-seque. mahitivar aadharit manvi mendu aanee vrushananmadhye vyakt kele gele. manav genome assemblyne paach erikh 3 aar. aine. aii. pratilekhanchi vyakhya kelee. sandarbh pratilekhat pandhra exon hote, jyat exon 14 heey khulya vachan chaukatiche ardhe encoding hote. sandarbh erikh 3 pratilekh mendumadhye, pramukhyane neuronsmadhye, parantu vrushanat vyakt keela gela nahee. lahan" sandarbh pratilekhat saat exon hote, jyapaiki sandarbh sandarbh pratilekhanachya intron 6 varr tyache pahile exon mapping pramukhyane vrushanat vyakt kele gele hote. avasadarodhi upcharanchya pratisadat aanee siliyam nirmitimadhye erikh 3 vesicular karyavyatirikt, yaa janukachi abhivyakti stanacha karkarog aanee tvachecha sarcoma yasarkhya karkarogachya anek prakaranshi jodali gelee aahe. rachana mendu, dolha, fuffus, stun granthi, snayu, petutory granthi, vrushan, shwasanali aanee garbhashayat vyakt hote.
prathine.
manavanmadhil parasparkriya prathinanchi lambi 1,530 amino acid (aa) aahe aanee tyat tyat aanee aanee yaa adnyat karyachi done kshetre aahet. donhi duff pradesh sadhya vaishishtyikrut naheet, jaree teey manavansah eukeriotsmadhye aadhaltat. sadhya manavanmadhye rachana prathinanche teen dnyat samaroop aahet, aahet (canonical), (canonical) aanee aanee. itar pranyanmadhye yaa janukache anek prakar asatat. canonical erikh 3 prathine, jee tyachya sandarbh aar. aine. aii. pratilekhanatun encode kelee gelee hotee, heey western blot parkhadvare neuronsemadhil pramukh erikh 3 isophorm asalyache darshavile gele aahe.
rachana heey anoo prathine asalyacha andaj aahe, jeey sort II vishleshan aanee rachana aanee aanee sarkhya itar prathinanmadhye prathinanmadhye suchavalelya prathinanchya parasparsanvadavar aadharit aahe.
expassymadhye compute paee/emdblue sadhan vaparoon isoelectric pointsathi prathinanche vishleshan kartana asey aadhalun aale qee bahutek orthologsasathi rachana heey 4.6-5 chya phpasoon kinchit amleey aahe. expassiveril netphos sadhanacha vapar karoon pudhil vishleshanat asey aadhalun aale qee mothya sankhyene phosphorylated serin, madhyavarti sankhyene phosphorylated threonines aanee kahee phosphoilated tyrosines aahet.
tathapi, prayogik aakadevarine spashtapane dakhavun dile qee tinhi dnyat samarupansah erikh 3 prathine, cytoplasmamadhe sthanik aahet parantu kendrakat naheet. canonical" erikh 3 prathinanche aanvik vajan (emm. doubleu.) 168.5 keey. dii. asel assa andaj vartavanyat aala hota, parantu western blotdware ~ 250 keey. dii. varr bandche nirikshan kele gele. andajit aanee nirikshan kelelya emm. doubleu. madheel haah lakshavedhi farak (> (>. dii.) glycosylation kinwa phosphorylationsarkhya anuvadanantarchya badalanmule honyachi shakyata nahee, parantu tyachya amino acid kramatil glutametchya (eae) uchch samagrimule. mageel abhyasanni nondavale aahe qee glutamate (eae) aanee/kinwa espartate (dii) chey uchch praman asaleli prathine, amleey bajuchya sakhalyansah amino acid, western blot vishleshanadarmyan andajapeksha jaast spasht emdblue moolye pradarshit karoo shakatat.
prathinanchi rachana.
rachana prathinanchi duyyam rachana aahe jee pramukhyane alfa helices aanee jaiv-mahitee vishleshanavar aadharit yadruchchik coil aahet. manavanmadhye parasparkriya chya trutiyak sanrachanet done ghatak asatat jeey ubiquitinsarkhe asatat-jase qee 2 sakriy karnare enzyme enzyme aanee alginage.
prathinanchi parasparkriya.
parasparkriya prathinancha pudhil prathinanshi parasparsanvad sadhanyacha andaj vartavanyat aala aahe kinwa prayogikdrushtya tyache nirikshan karnyat aale aaheh

