slotoxin

slotoxin heey 'centruroids noxius' hoffman vinchuchya vishatoon tayar jhalele peptide aahe. heey lahan vinchu vish super familishi sambandhit aahe.
vilgikaran paddhat.
slotoxinchya vilgikaranasathi, 'centruroids noxius' prajatichya vinchu vishasathi prayogshalet dudh pajale jaatat. kachche vish aasavan kelelya panyat virghalale jaat aahe aanee firavale jaat aahe. supernatent vegale kele jaate. tyanantar sakriy ansh aanakhi vegala keela jaato.
rachana.
37 amino acid peptide heey caribdotoxin up-kutumbatil (αktx1) aahe aanee tyala 11 kramankacha sadasya kramank denyat aala hota. αktx1.11 neey sastan pranyanchya maxic vahinyansathi (etch. ess. ell. oo.) vishishtata ughad kelee, tyamule tyala slotoxin asey naav denyat aale. tyacha kram etch-thra-phii-ill-esp-valle-ess. see. aay. ess. (1)-thra-valle-sair-liss-glue-see. aay. ess. (2)-trp-all-pro-see. aay. ess. (3)-lease-all-all-phay-gly-valle-ess. pii.-aar. jee.-gly-lease-see. aay. ess. (1)-mett-gly-lease-lease-see. aay. ess. (2)-lease-see. aay. ess. aay. ess. (3)-tiir-valle-oh.
uddishte.
slotoxin keval α-upaghatakanni (kd = 1.5 nm) banalelya uchch chalakata calcium-sakriy potassium vahinyanna ulatya paddhatine avarodhit karate. α-aanee β1 upaghatakanni banalelya uchch chalakata calcium-sakriy potassium vahinyanna aparivartaniyapane avarodhit karate. α-aanee β4-upaghatakanni banalelya uchch chalakata calcium-sakriy potassium vahinyanna aparivartaniyapane aanee kamkuvatpane avarodhit karate. itar potassium vahinyanvar tee konatihi kriyashilata darshavat nahee.
krutichi paddhat.
slotexchya sakaratmak prabharit prushthbhagacha (see-terminal) potassium-vahinyanchya nakaratmak prabharit chhidra pradeshashi vishisht alp-shrenicha parasparkriya asato jyamule vahini avarodhit hote. slottex aanee maxic vahinyanmadhil vishisht hydrophobic avashesh-avashesh parasparsanvad dekhil vishari-vahini parasparsanvadat yogdan deu shakatat. potassium vahinitil aanakhi eka pradesh (slotexchya aine-terminalla lagoon asalela) vishari-chhidra parasparsanvadachya jagechya samore aahe aanee maxic β upaghatkandware vahini nakabandichya modulationsathi parinam houu shakato.
maxic vahini chhidra tayar tayar α-upaghatkasobat sanvad sadhanyasathi slottex suchavala jaato.
dwimatrik abhikriyedvare chhidra rokhane.
visharipana.
mothya-vahak vidyutdab aanee calcium-sakriy potassium (maxic, bii. keey.) vahinya hii aantarik puttle prathine aahet jee mendu aanee gulgulit snayunsah vividh prakarchya uutinmadhye uttejana niyantrit karatat.

