
gliadine

gliadine (prolamincha eka prakar) haah gahoo aanee itar anek trundhanyanmadhye gavat vansh "triticum" madhye asalelya prathinancha eka varg aahe. glutencha eka ghatak asalele gliadines, becking darmyan breadla yogyaritya vadhanyachi kshamata denyasathi aavashyak aahet. gavhachya biyanyachya gluten anshatil done mukhya ghatak gliadines aanee glutenins aahet. heey gluten gavhachya pithasarkhya utpadananmadhye aadhalate. gluten heey gliadines aanee gluteninsmadhye samaan pramanat vibhagale jaate, jaree vividh strotanmadhye farak aadhaltat.
gliadines aanee glutenins heey donhi panyat virghalanare nasatat, parantu gliadines 70 takke jaleey ethanolmadhye virghalanare asatat. gliadineche teen mukhya prakar aahet (α, γ aanee ω), jyasathi shareer seliyak (kinwa seliyak) rogat asahishnu aahe. yaa rogache nidan alikade sudharat aahe.
gliadine aatadyansambandhi upakala olandu shakate. glutenyukt padarth khanari nirogi manvi maata, tyanchya aaichya dudhat aaa-apghatit gliadinchi uchch patali asate.
prakar.
α, γ aanee ω gliadineche prakar aine-terminal cysteine domenmadhil tyanchya amino aesidchya anukramanchya aadhare vegale kele jaatat aanee vegale kele jaatat.
rasayanshastra.
gliadines hii antargatpane avyavasthit prathine aahet, mhanje tyanche aakar satat badalat asatat, jyamule tyancha abhyas karane katheen hote. prathinanche pratimeche vishleshan aanee sanganakeey anukaran heey darshavate qee gliadinescha sarasari aakar lambvartulakar aakaracha asato. adhik visheshtah prathinanmadhye hydrophobic gabha aanee sail avyavasthit shepatisah thodishi-dhruvasarkhi rachana asanyachi shakyata aahe. gluteninsarkhya itar gluten prathinanchya tulanet, jeey diasulphide bandhanmule polymerche vistarit jaale tayar karatat, gliadines heey peshitil monomeric renu asatat, jaree teey anek prakare khoop samaan asale tarihi. visheshtah qamee aanvik vajanache glutenins jyaa prakare samaan asatat, tyaa pramanech tyanchya systeins anek gliadineschya barobarichya thikani sthit asatat. tathapi, gliadines peshinmadhye polymer tayar karoo shakat naheet kaaran hydrophobic parasparsanvadamule sanshleshanaveli tyachya systeinsdware intra-cheen diasulphide bandh tayar hotat.
mothya hydrophobic vibhag, polly-kyu aanee punaravrutti kramanmule gliadines mothya oligomersmadhye ektrit honyas aanee itar gluten prathinanshi sanvad sadhanyas saksham asatat. heey vibhag hydrophobacklinna ektrit karanyachi shakyata aahe, drav-drav tappa vegala, sambhavyapane β-patrake ektrit karatat kinwa tyachya sanrachanatmak gunadharmandware fakt guntalele asatat. 
jaiv rasayanshastra.
gliadines heey prolamine aahet aanee electrophoretic gatishilata aanee isoelectric foksinghchya aadhare vegale kele jaatat. gliadine peptides sakriy vahatukidvare aatadyansambandhi adthala paar karatat. 
chayapachay.
gluteninchya nirmitimadhye glutenins gliadines tyanchya bhoomikesathi olakhale jaatat. teey ethanolmadhye kinchit virghalatat aanee tyat keval intramolecular diasulphide duve asatat. teey ann-vyutpann rogjananchi kahee sarvottam udaharane dekhil detat. seliyak rog asalele lock (jyanna gluten-sensitive enteropathy asehi mhanatat) α, β aanee γ gliadinsasathi sanvedanshil asatat. doubleu. dii. artikeriya aanee bekarcha damaa asalelyanna ω-gliadineschi sanvedansheelata asate.
gliadine sanvedanshil enzymesathi (jase qee superoxide dismutage, jeey glysodine tayar karnyasathi gliadinshee misalale jaate) eka upayukt vitaran paddhat mhanoon dekhil kaam karoo shakate-heey tyanna potatil aamlanpasun sanrakshn karnyas madat karate jyamule vighatan hote.
gliadineschya upayukt varnanasathi pahah
demideted gliadine.
glutenchya aaml kinwa utsechak upcharadvare deamidated gliadine tayar kele jaate. transglutaminaz uutiche enzyme kahee mubalak glutaminesche glutamic aesidmadhye rupantar karate. gliadines heey alcoholmadhye virghalanare asatat aanee annache guna badallyashivay itar padarthanmadhye (dudhasarkhe) misalale jaau shakat naheet, mhanoon heey kele jaate. demideted gliadine panyat virghalate. deamidated α-/ β-gliadinchi pesheey pratikarshakti α/β-gliadinpeksha khoop jaast asate aanee parinami lakshaniy gluten-sanvedanshil enteropathy houu shakate.
seliyak rog.
seliyak rog (kinwa seliyak rog) haah eka junat, rogpratikarak-madhyasthi aatadyancha vikar aahe, jyamadhye shareer glutencha eka ghatak asalelya gliadinla asahishnu hote. seliyak rog asalelya vyakti gahoo, java aanee raichi aajivan asahishnuta darshavtat-yaa sarvanmadhye prolamine asatat. gliadine prathinanmadhye anuvanshikdrushtya sanvedanshil vyaktinmadhye asamanya rogpratikarak pratisadamule autoimmune enteropathyla uttejit karanyachi kshamata asate. gliadine prathinanmadhil vishisht amino acid anukram yaa kriyaklapas jababdar asatat.
yaa rogachi mukhya samasya ashee aahe qee too byavachada anek varshe olakhala jaat nahee, asha paristhitit too anek avyavanna gambhir nuksan pohochavu shakato aanee bahutek prakarane sadhya olakhali jaat naheet, nidan jhaleli naheet aanee upchar naan keleli aahet. heey aatadyansambandhi upkalamatil dii-eminated gliadine polypeptide sakhalyanchya see. dii. 4 + tii. peshi olakhanyamule hote. see. dii. 8 + tii peshi nantar upkalamadhye pravesh karatat aanee gliadine aanee transglutaminessathi vishisht aine. keey. receptors vyakt karatat jyamule intrapethalial tii peshi apoptosismadhye madhyasthi karoon enterocytescha naash karatat. abhijat nasaleli lakshane" asalela seliyak rog haah sarvat samanya vaidyakeey prakar aahe aanee too mothee mule (2 varshanpeksha jaast vayachi), paugandavasthetil aanee praudhanmadhye aadhalato. heey jatharantratil saumya kinwa agadi anupasthit lakshane aanee aatdyambaheril abhivyaktinchya vistrut shrenidware darshavile jaate jyat sharirachya konatyahi avyavacha samavesh asoo shakato aanee mule (kiman 43 takke prakarananmadhye) aanee praudhanmadhye donhimadhye heey purnapane lakshanrahit asoo shakate. upchar naan kelyas seliyak rogamule shoshan, jivanacha darja qamee hone, lohachi kamatarata, austeoporosis, aatadyansambandhi lymphomacha dhoka vadhane aanee mrutyudar vadhu shakato. madhumehacha prakar 1, thyroiditis, gluten ataxia, psoriasis, code, autoimmune hipatities, dermatities herpetiformis, primary sclerosing collangitis aanee itar kahee svayampratikar roganshi yacha sambandh aahe.
seliyak rogasathi ekmev upalabdh upchar mhanje kadak lus-mukt aahar jyamadhye prabhavit vyakti lus-yukt konatihi utpadane ghet nahee. parvadananya aanee adhik changlya upcharansathi shodh ghenyat aale aahet, parantu konatehi gluten khane talhane haah ekmev upchar aahe.