riboflavin

riboflavin, jyala jivansatva jyat asehi mhanatat, heey annamadhye aadhalanare jivansatva aahe aanee aaharatil purak mhanoon vikale jaate. flavin mononucleotide aanee flavin edenine dynucleotide yaa done pramukh saha-utsechakanchya nirmitisathi heey aavashyak aahe. heey saha-utsechak urja chayapachay, pesheey shwasan aanee pratipinde nirmiti, tasech samanya vaadh aanee vikasat guntalele asatat. niacin, jivansatva aanee aanee folletchya chayapachayasathi dekhil saha-utsechakanchi aavashyakta asate. corneal patal honyachya upcharansathi riboflavin lihoon dile jaate aanee tondawate ghetalyane praudhanmadhye ardhashishi dokedukhiche praman qamee houu shakate.
riboflavinchi kamatarata durmil aahe aanee sahasa itar jivansatve aanee poshak tattvanchya kamataratesah asate. tondawate purak aushadhe deuun kinwa injectiondware heey talhale kinwa upchar kele jaau shakate. panyat virghalanare jivansatva mhanoon, poshanvishayak aavashyaktanpeksha jaast sevan kelele konatehi riboflavin sathavale jaat nahee; teey ektar shoshale jaat nahee kinwa shoshale jaate aanee mutrat patkan utsarjit hote, jyamule mootrala chamakdar pivala rung yeto. riboflavinchya naisargik strotanmadhye maans, maase aanee pakshi, undy, dugdhajanya padarth, hiravya bhajya, mashroom aanee badam yancha samavesh hoto. kahee deshanna dhanyat tyachi bharr ghalanyachi aavashyakta asate.
riboflavin 1920 madhye shodhale gele, 1933 madhye vegale kele gele aanee 1935 madhye pahilyanda sanshleshit kele gele. tyachya shuddha, ghan swarupat, tee panyat virghalanari pivali-naringi sfatikeey puud aahe. jivansatva mhanoon tyachya karyavyatirikt, tyacha vapar ann rangdravya mhanoon keela jaato. jaivasanshleshan heey jivanu, burshi aanee vanaspatinmadhye hote, parantu pranyanmadhye nahee. riboflavinche audhyogik sanshleshan suruvatila rasayanik prakriyecha vapar karoon sadhya kele gele hote, parantu sadhyache vyavsayik utpadan burshi aanee anuvanshikdrushtya sudharit jivanunche prabhed vaparoon kinwan paddhatinvar avalambun aahe.
vyakhya.
riboflavin, jyala jivansatva jyat asehi mhanatat, heey panyat virghalanare jivansatva aahe aanee bii jivansatvanpaiki eka aahe. vitamars mhanoon olakhalya dilya anek rasayanik sambandhit rupanmadhye rupanmadhye follet aanee jivansatva bii 6 chya ulat, riboflavin heey keval eka rasayanik sanyug aahe. flavin mononucleotide (eff. emm. aine., jyala riboflavin-5 '-phosphet asehi mhanatat) aanee flavin edenine dynucleotide (phaid) yaa saha-utsechakanchya sanshleshanatil heey eka prarambhik sanyug aahe. phaid haah flavincha adhik mubalak prakar aahe, joou serve prajatinchya genomemadhe (flavoproteom) flavin-aadharit encoded prathin janukanchya sankhyechya 75 takkeshi bandhala jaato aanee 84 takke manvi-encoded flavoproteinsasathi saha-utsechak mhanoon kaam karato.
tyachya shuddha, ghan swarupat, riboflavin hii pivalya-naringi rangatil sfatikeey puud aahe, jicha thoda gandh aanee kadoo chav asate. heey paanee aanee jaleey soodiyam chloride dravnansarkhya dhruviy dravkanmadhye vidravya aahe aanee alcoholmadhye kinchit vidravya aahe. chloroform, benzin kinwa acetone sarkhya dhruviy nasalelya kinwa kamkuvat dhruviy sendriya dravkanmadhye teey vidravya nasate. dravanat kinwa korade sathavan kartana, jarr prakashachya samparkat naan aalyas, riboflavin ushnatemadhye sthir asate. jevha teey vighatit honyasathi garam kele jaate, tevha teey nitrick auxide asalele vishari dhune sodate.
karye.
eff. emm. aine. aanee phaid yaa done pramukh saha-utsechakanchya nirmitisathi riboflavin aavashyak aahe. heey saha-utsechak urja chayapachay, peshi shwasan, pratipinde utpadan, vaadh aanee vikasat guntalele asatat. carbohydrates, prathine aanee charbichya chayapachayasathi riboflavin aavashyak aahe. tryptophane niyasinmadhye (jivansatva (jivansatva rupantar honyas fadche yogdan asate aanee jivansatva aanee chey saha-utsechak pyridoxal 5 '-phosphatemadhe rupantaran karnyasathi eff. emm. aine. chee aavashyakta asate. homocysteinchi samanya parisancharan patali rakhanyat riboflavincha samavesh asato; riboflavinchya kamataratemadhye, homocysteinchi patali vadhate, jyamule hriday v raktavahinyasambandhi rogancha dhoka vadhato.
redox pratikriya.
redox pratikriya yaa asha prakriya aahet jyat electronche hastantaran samavisht asate. flavin saha-utsechake manavanmadhil andaje 70-80 flavoenzymeschya karyas samarthan detat (aanee serve jivanmadhye shekado, jyat pracheen, jivanu aanee burshijanya jeenomdware encode kelele aahet) jeey eka kinwa done-electron redox pratikriyansathi jababdar aahet jeey flavinschya oxidised, ardh-qamee aanee purnapane qamee jhalelya rupanmadhye rupantarit karnyachya kshamatevar bhandwal karatat. antarjaniy antioxidant, glutathionchya nirmitisathi aavashyak asalele enzyme, glutathione reductace kriyakalapansathi dekhil waid aavashyak aahe.
sookshm poshak tatvanche chayapachay.
riboflavin, eff. emm. aine. aanee phaid heey niacin, jivansatva aanee aanee folletchya chayapachayat guntalele aahet. tryptophanepasoon niacin-yukt saha-utsechakanchya, nadd aanee nadpeachya sanshleshanat, kineuranine 3-monoxygenase yaa phaid-aashrit enzymecha samavesh hoto. aaharat riboflavinchya kamataratemule naad aanee nadapiche utpadan qamee houu shakate, jyamule niyasinachya kamataratela chalana milate. jivansatva aanee chey tyachya saha-utsechakanmadhye, pyridoxal 5 '-phosphet synthessmadhye rupantaran, yaat pyridoxine 5'-phosphet auxidase yaa enzymecha samavesh asato, jyasathi eff. emm. aine. chee aavashyakta asate. follet chayapachayat guntalelya 5,10-methylinetrahydrophol reductase yaa enzymela homocysteinpasoon amino acid, methionine tayar karnyasathi fadchi aavashyakta asate.
riboflavinchya kamataratemule aaharatil khanij, loh, jeey haemoglobin aanee laal raktpeshinchya nirmitisathi aavashyak aahe, tyache chayapachay bighadte asey disate. jyaa lokanmadhye riboflavin aanee loh yaa donhinchi kamatarata aahe, tyanchyat riboflavinchi kamatarata qamee kelyane lohachya kamataratechya raktakshayavar upchar karnyasathi loh purakatechi parinamkarakta sudharate.
sanshleshan.
jaivasanshleshan.
jaivasanshleshan heey jivanu, burshi aanee vanaspatinmadhye hote, parantu pranyanmadhye nahee. ribulose 5-phosphet aanee gwanosin triphosphate heey riboflavinche jaivasanshleshak purvavarti aahet. pahilyache ell-3,4-dihydroxy-2-beautanon-4-phosphatemadhe rupantar hote tarr nantarche 5-emino-6-(dii-ribitilamino) yurasilmadhye yurasilmadhye pratikriyanchya maliket rupantarit hote. hii done sanyuge nantar margavaril upantya tappyasathiche thurr asatat, jeey pratikriyemadhye lumazine synthes yaa enzymedware utprerit hotat.
jaivasanshleshanachya antim tappyat, 6,7-diamethyl-8-ribitilumazine done renu riboflavin synthes yaa enzymedware dismutation pratikriyemadhye ekatra kele jaatat. yamule riboflavincha eka renu aanee 5-emino-6-(dii-ribitelamino) eurasilcha eka renu tayar hoto. nantarchya kramane mageel pratikriyevar punarvapar keela jaato.
riboflavinche eff. emm. aine. aanee phaid yaa sahghatkanmadhye rupantaran riboflavin kinness aanee phaid synthetage yaa enzymesdware kele jaate, jeey kramanusar karya karatat.
audhyogik sanshleshan.
riboflavinchya audhyogik-pramanatil utpadanat vividh sukshmajivancha vapar keela jaato, jyat 'aashbya gossipi', 'candida famata' aanee 'candida flavoury' yasarkhya philaments burshi tasech 'corinebacterium ammoniagence' aanee 'basilus subtillis' yaa jivanuncha samavesh aahe. "buub. riboflavinche utpadan vadhavanyasathi aanee pratijaivik (ampicillin) pratikar chinhak sadar karnyasathi anuvanshikdrushtya sudharit kelele subtillis, khadya aanee ann balkatisathi riboflavin tayar karnyasathi vyavsayik staravar vaparale jaate. 2012 paryant asha kinwan prakriyedvare darvarshi 4,000 tanpeksha jaast utpadan jhaale.
hydrocarbons kinwa sugandhi sanyuganchya uchch sandratechya upasthitit, kahee jivanu kadachit eka snrakshak yantrana mhanoon riboflavinche jaast utpadan karatat. asach eka jeev mhanje "micrococcus lutius" (american prakarcha sanwardhan sangrah taana kramank aii. tii. see. see. 49442), joou pyridinavar vadhatana riboflavinchya utpadanamule pivala rung vikasit karato, parantu sasinik esidsarkhya itar tharanvar vadhalyavar nahee.
prayogshaletil sanshleshan.
riboflavinche pahile sampoorn sanshleshan richard kuhnachya gatane kele. dii-raybojcha vapar karoon reductive aminishandware tayar kelelya paryayi anilynla antim tappyat alloxons ghanikaran karnyat aaleh
vapar.
parpatalache patal hone yavar upchar.
keratoconus haah parpatalacha ectasiacha sarvat samanya prakar aahe, joou parpatalacha haloohaloo patal honara prakar aahe. yaa sthitivar parpataliche collegen paraspar jodanidware upchar kele jaatat, jyamule parpatalichi kadakpana vadhate. parpatalache sthanik riboflavin dravan lavoon paraspar jodani sadhya kelee jaate, jeey nantar atinil prakashachya samparkat yete.
ardhashishi pratibandh.
2012 chya margdarshak tattvanmadhye, american academy auph neurologyne mhatale aahe qee uchch-matra asalele riboflavin (400 mii. gra.) heey 'kadachit prabhavi aahe aanee ardhashishi pratibandhasathi vicharat ghetale pahije', hii shifaras yooke national migraine centerne dekhil dilee aahe. 2017 chya punaravalokanat asey nondavale gele aahe qee kiman teen mahinyansathi darroj 400 migra darane ghetale jaanare riboflavin praudhanmadhye ardhashishi dokedukhichi varanvarta qamee karoo shakate. mule aanee paugandavasthetil ardhashishi pratibandh kinwa upcharansathi uchch-matrechya riboflavinavaril sanshodhan anirnit aahe aanee tyamule purak aaharanchi shifaras kelee jaat nahee.
khadya rung.
riboflavincha vapar ann rung (pivalya-naringi sfatikeey puud) mhanoon keela jaato aanee europemadhye ann padarth mhanoon vaparnyasathi tyala eae. kramank, eae. 101 asey naav dile jaate.
aaharvishayak shifarasi.
national academy auph medicine 1998 madhye riboflavinsathi andaje sarasari aavashyakta (qaan) aanee shifaras kelele aahar bhatte (aar. dii. aii. ess.) adyayavat kele. 14 varshe aanee tyahoon adhik vayachya mahila aanee purushansathi riboflavinsathi anukrame 0.9 mii. gra./divas aanee 1.1 mii. gra./divas aahet; aar. dii. aii. anukrame 1.1 aanee 1.3 mii. gra./divas aahet. sarasaripeksha jaast garja asalelya vyaktinna pureshi sevan patali pradan karnyasathi aar. dii. aii. heey kananpeksha jaast asatat. garbhadharanedarmyan aar. dii. aii. 1.4 mii. gra./divas aahe aanee stanpan sevan mahilansathi aar. dii. aii. 1.6 mii. gra./divas aahe. 12 mahinyanchya vayaparyantchya arbhakansathi, purese sevan (aii. aay.) 0.3-0.4 migra/divas aahe aanee 1-13 varshe vayogatatil mulansathi aar. dii. aii. vayanusar 0.00 teey 0.9 migra/divas vadhate. surakshitatesathi, jevha purava puresa asato tevha iom jivansatve aanee khanijansathi sahan karnyayogya uchch sevan patali (ulls) nishchit karate. riboflavinchya babatit ool nasate, kaaran jaast matremule tayar pratikool parinamansathi manvi mahitee upalabdh nasate. ektritpane qaan, aar. dii. aii., ayas aanee ool yanna aahar sandarbh sevan (dii. aar. aay. ess.) asey mhanatat.
european ann suraksha pradhikaran (eae. eff. ess. aii.) mahitichya samoohik sanchala aahar sandarbh moolye mhanoon sandarbhit karate, jyamadhye aar. dii. aii. aivaji loksankhya sandarbh sevan (pii. aar. aay.) aanee kanapeksha sarasari aavashyakta asate. aii. aay. aanee ulchi vyakhya united statesmadhye kelyapramanech kelee jaate. 15 varshe aanee tyahoon adhik vayachya mahila aanee purushansathi, 1 mii. gra./divas ashee prathamik kimmat nishchit kelee jaate. garodarpanat priri 1.9 migra/divas aahe aanee stanpan sevan mahilansathi priri 2 migra/divas aahe. 1-14 varshe vayogatatil mulansathi, pris vayanusar 0.6 teey 1.4 mii. gra./divasaparyant vadhato. heey priz yuu peksha jaast aahet.ess. aar. dii. ess. eae. eff. ess. aii. neey yu. sarkhech jastit jaast surakshit sevan dekhil manale.ess. national academy auph medicine nirnay ghetala qee ool seet karnyasathi pureshi mahitee nahee.
surakshitata.
manavanmadhye, jaast pramanat sevan kelyane tayar tayar riboflavin vishaktatecha konatahi purava nahee aanee doses vadhalyane shoshan qamee karyaksham hote. konatehi atirikt riboflavin mutrapindadware mutrat utsarjit kele jaate, parinami flavinuria mhanoon olakhala jaanara chamakdar pivala rung tayar hoto. migrainechi varanvarta aanee tivrata yavar upchar karnyasathi riboflavinchya parinamkaraktevar vaidyakeey chachanidarmyan, 3-12 mahinyanchya kalavadhisathi lokanna darroj 400 migraparyant riboflavin tondawate denyat aale. otipotat dukhane aanee atisar heey nondavalelya dushparinamanpaiki eka hote.
label.
tumchyasathi.ess. ann aanee aaharatil purak label karnyachya uddeshane, seva detanachi rakkam dainandin mulyachya takkewari (% dv) mhanoon vyakt kelee jaate. riboflavin labeling uddeshane dainandin mulyacha 100% 1.7 migra hota, parantu 27 meey 2016 paryant, rdashi sahmat honyasathi too 1.3 migraparyant sudharit karnyat aala. junya aanee naveen praudh dainandin mulyanchi sarani sandarbh dainandin sevanamadhye dilee jaate.
srot.
united states department auph agriculture, krishi sanshodhan seva ann rachana databases rakhate jyatoon shekado khadyapadarthanmadhil riboflavin samagri shodhali jaau shakate.
gavhachya dalanvalanamule riboflavinche 85 takke nuksan hote, tyamule kahee deshanmadhye pandhare peeth samruddha hote. balasathiche annapadarth, nyaharitil dhanye, pasta aanee jivansatva-samruddha ann badalanyachya utpadananmadhye dekhil riboflavin misalale jaate. drav utpadananmadhye riboflavincha samavesh karane katheen aahe kaaran tyachi panyat vidravyata qamee aahe, mhanoon riboflavin-5 '-phosphatechi (eff. emm. aine., jyala rangdravya mhanoon vaparale jaate tevha eae101 dekhil mhanatat) aavashyakta aahe, joou riboflavincha adhik vidravya prakar aahe. bhakariche sanwardhan aanee khanyasathi tayar asalelya nashtyachya trundhanyanche jivansatvachya aahar purvathyat lakshaniy yogdan asate. mukt riboflavin heey naisargikaritya prathin-baddh eff. emm. aine. aanee fads prani-strot asalelya khadyapadarthanmadhye asate. gayinchya dudhat pramukhyane mofat riboflavin asate, parantu eff. emm. aine. aanee phaid donhi qamee pramanat asatat.
tatbandi.
kahee deshanmadhye dhanyayukt khadyapadarthanche balkatikaran aavashyak aahe kinwa shifaras kelee jaate. 2021 paryant, 56 deshanmadhye, mukhytah uttar aanee dakshin america aanee aagney aafriketil, gavhache peeth kinwa makaa (makyache) peeth, riboflavin kinwa riboflavin-5 '-phosphet sodiums ann pushtikaranachi aavashyakta aahe. nirdharit rakkam 1.3 teey 5.75 migra/kilo paryant asate. atirikt 16 deshancha swayamsevi tatbandi karyakram aahe. udaharanarth, bharat sarkar maida (pandhara) aanee aata (sampoorn gahoo) pithasathi 4 milligram/kilochi shifaras karate.
shoshan, chayapachay, visarjan.
aaharatil 90 takkyanhun adhik riboflavin heey prathin-baddh eff. emm. aine. aanee fadchya swarupat asate. potachya gastric aesidchya samparkat aalyane saha-utsechake mukt hotat, jee nantar mukt riboflavin sodanyasathi nikatvarti lahan aatadyat utsechakedware hydrolyse kelee jaatat.
jalad sakriy vahtook pranalidware shoshan hote, jyat kahee atirikt nishkriy prasar uchch sandratesah hoto. pitt kshar grahan sulabh karatat, tyamule jevha jivansatva jevanabarobar khalle jaate tevha shoshan sudharate. praudhanmadhil eka chhotyasha vaidyakeey chachanit asey nondavale gele aahe qee ekach matretoon shoshale jaau shakanare riboflavinche kamal praman 27 mii. gra. aahe. navyane shoshale gelele bahutek riboflavin yakrutadvare pahilya tappyat ghetale jaate, jeey soochit karate qee rakt plazmamadhye riboflavinche postprendial swaroop shoshanala qamee lekhoo shakate. teen riboflavin vahak prathine olakhali gelee aaheth aar. eff. vhee. tii. 1 lahan aatadyat aanee nalatahi asate; aar. eff. vhee. tii. 2 mendu aanee lalechya granthimadhye jaast pramanat vyakt hote; aanee aar. eff. vhee. tii. 3 lahan aatade, vrushan aanee prostatemadhe sarvadhik vyakt hote. yaa vahtook prathinanna encoding sevan janukanmadhye utparivartan jhalelya arbhakanvar tondawate dilya dilya riboflavinne upchar kele jaau shakatat.
riboflavinche ulatya paddhatine eff. emm. aine. madhye rupantar kele jaate aanee nantar pheda hote. riboflavinpasoon eff. emm. aine. paryant zink-aavashyak asalelya riboflavin kinezche karya aahe; ulat phosphetdware purn kele jaate. eff. emm. aine. pasoon fadparyant heey magneshiyam-aavashyak phaid synthesche karya aahe; ulat pyrophosphetdware purn kele jaate. phaid heey eka pratibandhatmak antim utpadan asalyache disate jeey tyachya swatachya nirmitiche niyaman qamee karate.
jevha lahan aatadyandvare atirikt riboflavin shoshale jaate, tevha teey raktatoon patkan kadhoon takale jaate aanee mutrat utsarjit kele jaate. laghvicha rung hydration sthitee biomarker mhanoon vaparla jaato aanee samanya paristhitit, laghaviche vishisht gurutva aanee mootra ausmolalityshi sambandhit asato. tathapi, mothya pramanat aavashyaktanchya atirikt pramanat riboflavinchya purakatemule laghvi samanyapeksha jaast pivali disate. samanya aaharatil sevanane, mutratil sumare done trutiyansh utpadan heey riboflavin asate, urvarit anshatah peshinmadhil oxidationmule hydroxymethyladhrybolybouffil chayapachay kele gele aahe aanee itar chayapachay mhanoon. jevha sevan shoshanyachya kshamatepeksha jaast hote, tevha riboflavin mothya aatadyat jaate, jithe teey jivanundware vividh chayapachayanmadhye rupantarit hote jeey malamadhye shodhale jaau shakatat. asey anuman aahe qee naan shoshalele riboflavin mothya aatadyatil sukshmajivakoshavar parinam karoo shakate.
kamatarata.
prasar.
united states aanee gavhache peeth kinwa makyache ann majboot karnyachya karyakramansah itar deshanmadhye riboflavinchi kamatarata asamanya aahe. yuu. aii. chya dvivarshik sarvekshananmadhye gola kelelya mahitivarun.ess. 20 varshe aanee tyahoon adhik vayachya 22 takke mahilanni aanee 19 takke purushanni riboflavin asalele, samanyatah jivansatva-khanij bahu-purak asalele purak sevan kelyache nondavale. purak nasalelya vaparkartyansathi, praudh mahilancha aaharatil sevan sarasari 1.74 migra/divas aanee purushancha 2.44 migra/divas aahe. hii matra anukrame 1.1 aanee 1.3 migra/divasachya riboflavinsathichya aar. dii. aii. peksha jaast aahe. serve vayogatansathi, sarasari, annacha vapar aar. dii. aii. peksha jaast hota. a 2001-02 u.ess. sarvekshanat asey nondavale gele aahe qee 3 takkyanhun qamee loksankhyene riboflavinchya andajit sarasari garajepeksha qamee sevan kele.
chinhe aanee lakshane.
riboflavinchya kamataratemule (jyala eriboflavinosis dekhil mhanatat) stomatitis hoto, jyachya lakshananmadhye fatalele aanee fatalele oth, tondachya tondachya jaljal (koneey stomatitis), ghasa khavkhavane, vednadayak laal jeebh aanee cases galane yancha samavesh hoto. dolhe khajanare, panyache, raktastrav karnare aanee prakashaprati sanvedanshil houu shakatat. riboflavinchi kamatarata hii raktakshayabarobar sambandhit aahe. dirghkal riboflavinchya jivansatvachyateeiimaamoolleeii yakrut aanee majjasanstheche adhahpatan houu shakate. riboflavinchya kamataratemule garbhavati mahilanmadhye preaclempsiacha dhoka vadhu shakato. garbhadharanedarmyan riboflavinchya kamataratemule hriday aanee avyavanchya vikruteensah garbhachya janm doshanmadhye parinam houu shakato.
jokhim ghatak.
riboflavinchi patali qamee honyacha dhoka asalelya lokanmadhye madyavyasani, shakahari kheladu aanee shakahari abhyasak yancha samavesh hoto. aaeene maans aanee dugdhajanya padarth talhale tarr garbhavati kinwa stanpan sevan striya aanee tyanchya balanna dekhil dhoka asoo shakato. bhook mandavane aanee lactose asahishnuta yamule riboflavinchya kamtaratecha dhoka vadhato. sharirikdrushtya kashti jeevan asalelya lokanna, jase qee kheladu aanee kamgaranna, adhik riboflavinche sevan karave lagoo shakate. hypothyroidism, adhivrukk apurepana aanee riboflavin transporterchi kamatarata asalelya lokanmadhye riboflavinche phaid aanee eff. emm. aine. madhye rupantaran bighadte.
karane.
riboflavinchi kamatarata samanyatah itar poshak kamataratansah, visheshtah itar panyat panyat jivansatve miloon aadhalate. riboflavinchi kamatarata prathamik asoo shakate (i.eae. niyamit aaharatil jivansatvachya jivansatvachya strotanmule) kinwa duyyam, jeey aatadyatil shoshanavar parinam sevan paristhiticha parinam asoo shakate. duyyam kamatarata samanyatah sharirala jivansatva vaparnyas saksham naan jhalyamule kinwa jivansatva utsarjanacha vadhata darr yamule udbhavtat. kamatarata honyacha dhoka dhoka aahar paddhatinmadhye shakaharipana aanee qamee dugdhajanya shakaharipanacha samavesh hoto. karkarog, hridayrog aanee madhumeh yasarkhya aajaranmule riboflavinchi kamatarata houu shakate kinwa vadhu shakate.
asey durmil anuvanshik dosh aahet jeey riboflavinche shoshan, vahtook, chayapachay kinwa flavoproteinschya vaparat tadjod karatat. yapaiki eka mhanje riboflavin vahatukdarachi kamatarata, jee purvi braun-vialetto-vanne lere syndrome mhanoon olakhali jaat asey. ess. ell. see. 52aii. 2 aanee ess. ell. see. 52aii. 3 yaa janukanche prakar, jeey anukrame aar. dii. vhee. tii. 2 aanee aar. dii. vhee. tii. 3 yaa vahak prathinansathi code karatat, sadosh aahet. arbhake aanee lahan mule snayuncha kamkuvatpana, shravanshakti qamee hone, sanvedanatmak ataxias sanvedanatmak lakshane, aaharat adachani aanee censorimotor akshatantunchya majjatantunchya vikaramule aanee kapalatil majjatantunchya vikaramule shwasan samasya yasah kapalatil majjatantunchi kamatarata upasthit karatat. upchar naan kelyas, riboflavin transporterchi kamatarata asalelya arbhakanna shwas ghenyas tras hoto aanee tyanna aayushyachya pahilya dashakat mrutyucha dhoka asato. mothya pramanat riboflavinche tondawate purak upchar karane heey jivanrakshak aahe.
chayapachayatil itar janmajat chukanmadhye riboflavin-pratisadatmak ekadhik esile-coa dehydrogenage kamatarata, jyala glutaric acidemia prakar 2 chaa upasanch mhanoon dekhil olakhale jaate aanee methylenetrahydropholate reductage enzymecha enzymecha prakar, joou praudhanmadhye uchch raktadab honyachya jokhamishi sambandhit aahe, yancha samavesh hoto.
nidan aanee moolyankan.
jevha jevha kamatarata sanshayaspad asate tevha vishisht nasalelya lakshanansah prakarananchi pushti karnyasathi riboflavin sthitiche moolyankan karane aavashyak asate. samanyapane riboflavinche sevan sevan nirogi praudhanmadhye ekoon riboflavinche utsarjan darroj sumare 120 microgram asate, tarr darroj 40 microgrampeksha qamee utsarjan hii kamatarata darshavate. ekhadya vyaktiche vay jasjase vadhate tasatase riboflavin utsarjanache praman qamee hote, parantu dirghakalin tanavachya kalat aanee kahee aushadhanchya vaparadarmyan vadhate.
erythrocyte glutathione reductase (ii. jee. aar.), erythrocyte flavin ekagrata aanee mootra visarjan heey manavanmadhye vaparale jaanare nirdeshak aahet. erythrocyte glutathione reductase kriyakalap gunank" (egrack) uutinchya sampruktateche aanee dirghakalin riboflavin sthitiche mojmap pradan karato. parinam kriyakalap gunank gunottar mhanoon vyakt kele jaatat, jeey sanwardhan madhyamat vyasanipanachya jodanisah aanee naan jodata enzyme kriyakalapadware nirdharit kele jaatat. 1 teey 1.2 chaa egrack soochit karato qee puresha pramanat riboflavin aahe; 1.2 teey 1.4 qamee manale jaate, 1.4 peksha jaast mhanje kamatarata darshavate. qamee sanvedanshil 'erythrocyte flavin paddhati' sathee, 400 aine. emm. oo. ell./ell. peksha jaast moolye pureshi manali jaatat aanee 270 aine. emm. oo. ell./ell. peksha qamee moolye kamatarata manali jaatat. mootra visarjan heey prati gramm creatininche riboflavinche aine. emm. oo. ell. mhanoon vyakt kele jaate. qamee 50 teey 72 aine. emm. oo. ell./jee. chya shreneet paribhashit kele jaate. kamatarata 50 aine. emm. oo. ell./grampeksha qamee aahe. aaharatil aavashyakta nishchit karnyasathi mootra visarjan bhaar chachanyancha vapar keela gela aahe. praudh purushansathi, tondawate dilelya matret 0.05 mii. gra. varoon 1.1 mii. gra. paryant vaadh karnyat aalee, tyamule mutratil riboflavinmadhye eka samanya resheey vaadh jhaali, jee tyanantarchya 24 tasanchya mootra sankalanasathi 100 microgramparyant pohochali. 1. 1 mii. gra. chya bhaar matrechya palikade, mootra visarjan vegane vadhale, jyamule 2.5 mii. gra. chya matresah, 24 tasanchya mootra sankalanasathi mootra utpadan 800 microgram hote.
itihas.
riboflavin" heey naav "raiboj" (sakhar jyache qamee jhalele roop, ribitol, tyachya sanrachanecha bhag aahe) aanee "flavin", ring-bhag jeey oxidised renula pivala rung dete (lattin "flaves", "pivala") yavarun aale aahe. oxidised swarupasah chayapchayamadhye udbhavnare qamee jhalele swaroop, naringi-pivalya suya kinwa sphatik mhanoon disate. aavashyak poshak tatve mhanoon jivansatve yaa konatyahi sankalpanechya aadhi alekzandar winter blithney sarvat aadhi nondavaleli olakh hotee. 1879 madhye, blithney gayinchya dudhachya matthacha panyat virghalanara ghatak vegala keela, jyala tyane 'lactochrome' asey naav dile, joou prakashachya samparkat aalyavar pivala-hirwa rung darshavato.
1900 chya dashakachya suruvatila, anek sanshodhan prayogshala undaranchi vaadh rakhanyasathi aavashyak asalelya khadyapadarthanchya ghatakanchi tapasani karat hotya. heey ghatak suruvatila charbi-vidravya 'vitamin aii' aanee panyat vidravya 'vitamin bii' madhye vibhagale gele hote. ('eae' 1920 madhye vagalanyat aala.) jivansatva buub madhye done ghatak asalyache pudhe manale gele, bii 1 navacha ushnata-sthir padarth aanee bii 2 navacha ushnata-sthir padarth. jivansatva bii 2 haah pelagra rokhanyasathi aavashyak ghatak asalyache tatpurte olakhale gele, parantu nantar niacin (jivansatva bii 3) chya kamataratemule yachee pushti jhaali. riboflavinchya riboflavinchya kamataratemule pelagramadhye pelagramadhye stomatitischya lakshanansarkhich, parantu tvachechya vyapak paridhiy jakhmanshivay lakshane disun yetat, yaa vastusthitimule haah gondhal nirman jhaala. yaa karanastav, manavanmadhye riboflavinchi kamatarata olakhanyachya itihasachya suruvatichya kalat yaa sthitila kadhikadhi 'pelagra sine pelagra' (pelagrashivay pelagra) asey mhatale jaat asey.
1935 madhye, paul gyorjee yanni rasayanshastradnya richard kuhn aanee doctor tii. wagner-joregne nondavale qee jyat-mukt aaharavar thevalelya undaranche vajan vadhane ashakya hote. khamirapasoon jyat vegale kelyane eka chamakdar pivala-hirwa pratideepak utpad disun aala jyane undaranna khalle asata samanya vaadh punarsanchayit kelee. punarsanchayit keleli vaadh pratidipiktechya tivratechya thet pramanat hotee. yaa nirikshanamule sanshodhakanna 1933 madhye jalad rasayanik jaiv-parikshan vikasit karane aanee nantar andyachya andyachya bhagapasoon ghatak vegale karane, tyala ovoflavin asey naav dene shakya jhaale. tyach gatane nantar mattha pasoon samaan tayari vegali kelee aanee tyala lactoflavin mhatale. 1934 madhye, kuhnachya gatane yaa flavinschee rasayanik rachana samaan asalyache olakhale, naav mhanoon 'riboflavin' varr sthayik kele aanee jivansatvache sanshleshan karnyas dekhil saksham hote.
1937 chya sumaras, riboflavinla 'jivansatva jee' asehi sambodhale jaat asey. 1938 madhye, richard kuhn yanna jivansatve, jyat jyat aanee aanee samavisht hote, tyavar kelelya karyasathi rasayanshastratil nobel puraskarane sanmanit karnyat aale. 1939 madhye, william etch. yanni kelelya vaidyakeey chachanidware, manvi aarogyasathi riboflavin aavashyak aahe yachee pushti jhaali. sebrel aanee roy eae. butler. striyanni qamee pramanat riboflavin asalela aahar ghetala, jyamule stomatitis aanee kamataratechi itar chinhe vikasit jhaali, jee synthetic riboflavinne upchar kelyavar ulatali gelee. purak aushadhe thambavali gelee tevha lakshane parat aalee.

