naloxegol

naloxegol (inn; pegilated naloxol; movantic aanee moventig hii vyapari nave) haah eka paridhiyapane karya karnara micro-opioid receptor antagonist aahe, joou astrazenecane vikasit keela aahe, jyala netra upcharshastrakadun parwana denyat aala aahe, opioid-prerit baddhakoshthatechya upcharansathi. junat, karkarog nasalelya vedna asalelya praudh rugnanmadhye 2014 madhye yala manyata denyat aalee. 25 mii. gra. chey doses 52 aathvadyansathi surakshit aanee changlya prakare sahan kele gele. opioid vedanshamak aushadhansah ekach velee dile asata, naloxegolne baddhakoshthateshi sambandhit dushparinam qamee kele, tarr vedanshamaktechi tulanatmak patali kayam thewali.
potdukhi, atisar, malmal, petke yene, ulatya aanee dokedukhi heey sarvat samanya dushparinam aahet. rugna sahasa vareel dushparinam naisargikaritya udbhavayala udbhavayala 24 tasanpeksha twarit aanalelya tatkal maghar ghenyachya sthitisarkhe asalyache varnan karatat. shuddha opioid virodhi mhanoon naloxegolmadhye gairavaparachi konatihi shakyata nasate.
afoochya alkalideshy rasayanik samya asalyamule naloxegol heey purvi united statesmadhye anusuchi II aushadh hote. 23 janewari 2015 roji tyache adhikrutpane niyantran radd karnyat aale. eff. dii. aii. aanee dii. aii. neey assa nishkarsh kadhalyanantar qee yaa sanyugatil rakt-menduchya adthalyachya abhedyatemule teey gair-savayiche banale aanee tyamule durupyogachi shakyata nahee, heey prescription aushadh mhanoon tyache punarvargikaran karnyat aale.
vaidyakeey vapar.
dirghakalin karkarog nasalelya vedna asalelya rugnanmadhye opioid-prerit baddhakoshthatechya (oo. aay. see.) upcharansathi naloxegol soochit kele jaate. naloxegol suru karnyapurvi konatyahi dekhbhalichya rechak padarthala bund karanyachi kinwa kiman 3 divas thevanyasathi shifaras kelee jaate. shevatchya jevananantar kiman done tasanni naloxegol rikamya potee ghetale pahije.
dushparinam.
naloxegolchya sarvat samanya dushparinamadhye heey samavisht aaheh 
pharmacodynamic gunadharm.
naloxegol jatharantramargatil micro-opioid receptorsmadhye opioid bandhan rokhate, asha prakare opioidshee sambandhit baddhakoshthata prabhav (jatharantra gatishilata aanee sankraman mandavane, hypertonicity, drav punarsoshan vadhane) qamee hote.
jarr naloxegol itar opioid virodhi aushadhansah dile gele tarr tyat mishrit prabhavachi aanee opioid kadhoon ghenyacha dhoka vadhanyachi shakyata asate.
krutichi yantrana.
rasayanikdrushtya, naloxygol heey α-naloxolche pegilated (polyethylene glycol-modified) vyutpann aahe. visheshtah, α-naloxolcha 6-α-hydroxyl gut, monomethoxy-samapt jhalelya n = 7 oligomarchya mukt hydroxyl gatashi eather linkejdware jodala jaato, joou ujavya bajula renuchya pratimechya khalchya davikade vistarlela darshavila jaato. aine = 7" heey done-carbon ethylenechi sankhya paribhashit karate aanee mhanoon jodalelya pegg sakhalichi sakhali lambi aanee "monomethoxy" heey soochit karate qee pegcha antim hydroxyl gut methyl gatane "aachchhadit" aahe. naloxolchya 6-α-hydroxyl bajuchya sakhaliche pegilation heey aushadh rakt-mendu adthala (bbb) paar karnyapasoon rokhate. tyamule, heey paridhiy-karyarat afoo loperamideche virodhi manale jaau shakate, jeey afoo-lakshya virodhi atisar agent mhanoon vaparale jaate, jeey samanya vishayanmadhye kendriya majjasansthemadhye jamaa honyat asamarthatemule paramparik afooche dushparinam karat nahee.

