
macrophage dahak prathine

macrophage dahak prathine (emm. aay. pii.) hii chemochines mhanoon olakhalya jaananya chemotactic cytokineschya kutumbatil aahet. manavanmadhye, emm. aay. pii.-1α aanee emm. aay. pii.-1β heey done pramukh prakar aahet, jyanna aata (naveen namkarananusar) anukrame see. see. ell. 3 aanee see. see. ell. 4 asey adhikrutpane naav denyat aale aahe. tathapi, kahivela itar nave aadhalu shakatat, visheshtah junya sahityat, ell. dii. 78α, 464.1 varr aanee manvi see. see. ell. 3 sathee gos 19-1 aanee 744 varr, manvi see. see. ell. 4 sathee ect-2, lagg-1, etch. see. 21 aanee jee-26. itar macrophage dahak prathinanmadhye emm. aay. pii.-2, emm. aay. pii.-3 aanee emm. aay. pii.-5 yancha samavesh hoto.
emm. aay. pii.-1.
mayap-1α aanee mayap-1β heey macrophage aanee monocytesdware tayar honare pramukh ghatak aahet, jeey bacteriachya endotoxin kinwa ill-1β sarkhya proinflammatory cytokinesdware uttejit jhalyanantar tayar hotat. parantu asey disate qee sakriy jhalyavar teey serve hematopoetic peshi aanee fibroblast, epithelial peshi, raktavahinyanchya gulgulit snayu peshi kinwa plateletsarkhya kahee ootee peshindware vyakt kele jaau shakatat. sansarg aanee jaljal yanvishayichya rogpratikarak pratisadasathi teey mahattvapoorn aahet. see. see. ell. 3 aanee see. see. ell. 4 heey bahya koshikeey proteoglycansi bandhale jaau shakatat, jeey tyanchya karyasathi aavashyak nahee parantu teey tyanchi jaivkriyashilata vadhavu shakate. rasayanik parinam rasayanik grahankartyanchya see. see. aar. 1 (legand see. see. ell. 3) aanee see. see. aar. 5 (legands see. see. ell. 3 aanee see. see. ell. 4) chya bandhanadware keela jaato aanee nantar sanket peshimadhye hastantarit keela jaato, asha prakare heey cytokines heey grahankartya asalelya konatyahi peshivar parinam karatat. mukhya parinam dahak asato aanee tyat pramukhyane chemotaxis aanee transandothelial sthalantar asate parantu kahee jaiv sakriy renu sodanyasathi peshi sakriy kelya jaau shakatat. heey chemokins monocytes, tii lymphocytes, dendritic peshi, aine. keey. peshi aanee plateletswar parinam karatat. teey dekhil manvi granulocytes (neutrophils, eosynophils aanee besophils) sakriy karatat jyamule tivra neutrophilic jaljal houu shakate. teey fibroblast aanee macrophagepasoon interleukin 1 (il-1), il-6 aanee tnf-α sarkhya itar dahak-samarthak cytokinesche sanshleshan aanee prakashan karnyas dekhil prerit karatat. see. see. ell. 3 aanee see. see. ell. 4 sathichi januke manvi gunasutra 17 aanee murine gunasutra 11 yaa donhivar sthit aahet.
teey anek peshindware, visheshtah macrophages, dendritic peshi aanee lymphocytesdware tayar kele jaatat. emm. aay. pii.-1 tyanchya chemotactic aanee soojanvirodhi prabhavansathi prasiddha aahet parantu homeostasisla dekhil protsahan deu shakatat. jaivbhautikiy vishleshan aanee ganiteey modelingne asey darshavile aahe qee emm. aay. pii.-1 ulatya paddhatine dravnamadhye rodd-aakarachya polymerche polydispers vitaran tayar karate. polymerisationmule emm. aay. pii.-1chya receptor-binding sites daphan hotat, asha prakare depolymerisation utparivartane sakriy manvi endotheliumvar monocytesna atak karnyasathi emm. aay. pii.-1 vadhavtat.
emm. aay. pii.-1. jee. emm. heey aanakhi eka macrophage dahak prathine aahe aanee naveen namkarananusar tyala see. see. ell. 9 asey naav denyat aale aahe. heey pramukhyane follical-sambandhit epithelial peshindware tayar kele jaate aanee see. see. aar. 1 chya bandhanadware aatadyatil piarchya pattyanmadhye dendritic peshi aanee macrophageschya chemotaxisasathi jababdar aahe.
emm. aay. pii.-1δ kinwa emm. aay. pii.-5 (see. see. ell. 15) dekhil see. see. aar. 1 aanee see. see. aar. 3 laa bandhate.
emm. aay. pii.-2.
emm. aay. pii.-2 haah see. ex. see. kemokin kutumbatil aahe, jyala see. ex. see. ell. 2 asey naav denyat aale aahe aanee too see. ex. see. aar. 1 aanee see. ex. see. aar. 2 chya bandhanadware karya karato. too pramukhyane macrophage, monocytes aanee epithelial peshindware tayar hoto aanee neutrofilschya daah aanee sakriyatechya strotatil chemotaxisasathi jababdar asato.
emm. aay. pii.-3.
emm. aay. pii.-3 gatamadhye done chemokins asatat. emm. aay. pii.-3α (see. see. ell. 20) aanee emm. aay. pii.-3β (see. see. ell. 19).
emm. aay. pii.-3α heey receptor see. see. aar. 6 laa bandhale jaate. see. see. ell. 20 heey sakriy epithelial peshindware shleshmal aanee tvachedvare tayar kele jaate aanee tii. etch. 17 peshinna jaljalichya thikani aakarshit karate. teey swatah tii. etch. 17 peshindware dekhil tayar kele jaate. heey pudhe sakriy bii peshi, smrutee tii peshi aanee aparipakv dendritic peshi aakarshit karate aanee duyyam lasika avayavanmadhye yaa peshinchya sthalantarat tyacha bhag asato. paripakv dendritic peshi see. see. aar. 6chey niyaman qamee karatat aanee see. see. aar. 7chey niyaman vadhavtat, jeey emm. aay. pii.-3bita sathee receptor aahe.
emm. aay. pii.-3β (see. see. ell. 19) heey duyyam lasika avyavanchya tii-peshi kshetranmadhye stromal peshindware tayar kele jaate aanee see. see. aar. 7 receptorshee bandhale jaate jyadvare praudh dendritic peshi lasika granthikade aakarshit hotat. heey dendritic peshindware dekhil tayar hote aanee nishkapat tii lymphocytes aanee bii lymphocytesna lasika granthimadhye pravesh karnyasathi aakarshit karate, jithe dendritic peshindware tyanna pratijan sadar kele jaau shakatat.
emm. aay. pii.-5.
emm. aay. pii.-5 (kadhikadhi emm. aay. pii.-1. dii. mhanatat) kinwa see. see. ell. 15 heey see. see. aar. 1 aanee see. see. aar. 3. yaa receptors bandhale jaate. tyat monocytes aanee eosinophilsasathi chemotactic gunadharm aahet aanee teey macrophages, besophils aanee kahee uutinchya peshindware vyakt kele jaate. damyachya rogvidnyanat tyachi bhoomika prastavit aahe.