delta endotoxin

delta endotoxin (δ-endotoxin) heey sukshmajantuchya "basilus thuringiensis" prajatindware tayar honare chhidra tayar karnare vishari padarth aahet. teey tyanchya kitaknashak krutisathi upayukt aahet aanee bii. tii. makaa/makyane tayar kelele prathamik vish aahet. bijkan tayar honyachya darmyan jivanu asha prathinanche sphatik tayar karatat (mhanunach tyanna kray toxins asey naav dile jaate) jyanna endosporechya pudhe parasporal boddy mhanoon dekhil olakhale jaate; parinami kahee sadasyanna parasporin mhanoon olakhale jaate. sayat (cytolytic) vish gut haah delta-endotoxincha eka gut aahe joou kray gatapeksha vegala aahe.
krutichi yantrana.
jevha ekhada keetak hii prathine grahan karato, tevha teey proteolytic klevejdware sakriy hotat. aine-terminal serve prathinanmadhye vibhajit kele jaate aanee kahee sadasyanmadhye see-terminal vistar vibhajit keela jaato. ekada sakriy jhalyavar, endotoxin aatadyachya upkalkashi bandhale jaate aanee catayan-nivadak vahinyanchya nirmitimule peshi lysis hote, jyamule mrutyu hoto.
anek varshe aminopeptidase aine aanee beaty vishari padarthanmadhil sambandhabaddal spashtata navhati. jaree aii. pii.-aine. kray prathinanna inn vitromadhye bandhate (soberon aanee itaranni punaravalokan kele. 2009 aanee pigot andd eller 2007), 2002 paryant aii. pii.-aine. sanrachanet badal jhalyamule pratikar kinwa agadi qamee jhalelya inn vitro bandhanachi konatihi prakarane dnyat navhati aanee pratikar yantrana itaki saral hotee yabaddal kahee shanka hotee. kharokhar, luo aanee itar. 1997, mohammed aanee itar. 1996, aanee jhu aanee itar. 2000 madhye 'sakaratmak' asey aadhalale qee heey lepidopterachya udaharananmadhye 'nahee' asey disun aale. tyanantar, tathapi, herero aanee itar. 2005 madhye nonexpression aanee beaty pratikar yanchyatil parasparsambandh darshavila gela aanee zhang aanee itaranchya 'helikoverpa aarmigeramadhye' vastavik pratirodh aadhalala. 2009 madhye, khajuria aanee itaranni lihilelya 'austriniya nubilalis' madhye. 2011, aanee baxter aanee itaranchya 'trichoplucia nee' madhye. 2011 aanee tivasiri aanee wang 2011 (serve lepidoptera dekhil). kahee prakarananmadhye, bahudha vishamule tyacha parinam nirman karnyasathi aavashyak asalelya anukramik bandhanamule, aii. pii.-aine. swatah pratikarshaktivar parinam karat naheet yachee pushti hott aahe. yaa kramane pratyek bandhan pavalachi saiddhantikdrushtya apariharya nahee, parantu jarr tee jhaali tarr antim chhidra nirmitichya parinamanmadhye yogdan dete.
rachana.
delta vishacha sakriy pradesh teen bhinn sanrachanatmak kshetranni banalela asatoh eka aine-terminal helical bundle domain () joou puttle antarbhut karane aanee chhidra tayar karnyat guntalela asato; receptor bindingmadhye samavisht beeta-sheet kendriya domain; aanee see-terminal beeta-sandwich domain () joou aine-terminal domenshee sanvad sadhun eka vahini tayar karato.
prakar.
"buub. thuringiensis 'delta endotoxin kutumbatil anek prathinanna encode karate, kahee strain ekach velee anek prakaranna encode karatat. bahutek plasmidver aadhalanare januk, delta-antotoxin kadhikadhi itar prajatinchya genomemadhe disatat, jaree 'buub' madhye madhye janukanpeksha qamee pramanat. thuringiensis ". janukanchi nave cockoge _ 1 sarkhi disatat, jee yaa prakaranat super family 3 kutumb buub upkutumb buub chey kray toxin darshavate.
"karkarog sanshodhanasathi manoranjak asaleli 'kray' prathine kray namkaranavyatirikt parasporin (pii. ess.) namkaranantargat soochibaddha kelee jaatat. teey kitakanna marat naheet, tarr tyaeivaji leukemia peshi maratat. sayat vishari padarth tyancha swatacha gut tayar karatat joou kray vishari padarthanpeksha vegala asato. serve 'radane' sphatik-swarupatil vishari padarth thet eka samaan mool samayik karat naheet. teen-kshetra nasalelya vishari padarthanchya udaharananmadhye, jyanna tarihi 'radane' asey naav aahe, tyamadhye kray 34/35 34/35 aanee sambandhit beeta-sandwich binary (binsarkhe) vishari padarth, padarth aanee anek beeta-sandwich parasporins yancha samavesh hoto.
anuvanshik abhiyantrikimadhye samavisht kelelya vishisht delta-endotoxinmadhye moone 863 madhye aadhalanare aahet aanee moone 810 madhye aadhalanare aadhalanare yancha samavesh hoto, jeey donhi makaa/makyache sanvardhit prakar aahet. aahet visheshtah upayukt aahe kaaran tee corn rootworm sarkhya colliopteran kitakanna marte, hii kriya itar kray prathinanmadhye disun yet nahee. itar samanya vishari padarthanmadhye kapus aanee makaa/makyamadhye makaa/makyamadhye aanee aanee yancha samavesh hoto. yavyatirikt, yavyatirikt haah manavanmadhye lasicha sahayak mhanoon prabhavi aahe.
kahee kitkanchya loksankhyemadhye delta endotoxinchya virodhat pratikar vikasit honyas suruvat jhaali aahe, 2013 paryant paach pratirodhak prajati aadhalalya aahet. done prakarchya delta endotoxin asalelya vanaspatincha pratikar mandavanyacha cull asato, kaaran donhi vishari padarthanvar ekach velee maat karnyasathi kitakanna vikasit vhave lagate. pratirodhak vanaspateensah bii. tii. nasaleli zaade lavalyane vish vikasit karnyasathi nivadicha dabav qamee hoil. shevati, done-vishari vanaspati eka-vishari vanaspati gheuun lavu nayet, kaaran eka-vishari vanaspati yaa prakaranat anukulan karnyasathi eka payari mhanoon kaam karatat.

