
dvigunit chromatin

bivalent chromatin heey dii. aine. aii. chey bhag aahet, jeey histone prathinanshi bandhalele aahet, jyamadhye ekach pradeshat epigenetic niyamak dadapun takanare aanee sakriy karnare donhi asatat. heey niyamak janukanchi abhivyakti vadhavanyasathi kinwa shant karnyasathi kaam karatat. heey niyamak ekmekanchya virodhat kaam karat asalyane, teey samanyatah vegvegalya velee chromatineshy sanvad sadhatat. tathapi, dvigunit chromatinemadhye, donhi prakarche niyamak ekach velee ekach kshetrashi sanvad sadhat aahet. dvigunit chromatin kshetra samanyatah pratilekhan ghatak janukanchya pravartkanshi sambandhit asatat jeey qamee staravar vyakt kele jaatat. dvigunit kshetra dekhil pluripotent bhrun stame peshi, januk chhap aanee karkarogamadhye vikasatmak niyaman karnyat bhoomika bajavate asey aadhalun aale aahe.
dvigunit epigenetic niyamak.
bivalent chromatin kshetranvar ekatra aadhalanare sarvat samanya virodhi epigenetic niyamak mhanje histone 3 lycine 4 (etch3keey4meey 3) aanee histone 3 lycine 27 (etch3keey27meey 3) vareel methylation chinhe. etch3keey27aiimaameae3 chinh janukala shant karate tarr etch3keey4aiimaameae3 chinh janukala kayamche shant houu dett nahee aanee aavashyakatenusar sakriy hote. bhrun stame peshi aanee chhapaleli januke sakriy (etch3keey4meey3) aanee dadapshahi (etch3keey27meey3) yaa donhi chinhanshi sambandhit asatat, kaaran teey sakriyatechi aavashyakta hoiparyant januk dadapanyachi parvanagi detat. jaree genomemadhe ekach thikani etch3keey4meey3 aanee etch3keey27meey3 chya saha-sthanikikaranasathi mubalak purave asale taree, bahutek purave asey suchavatat qee teey ekach renuvar hott naheet parantu tyach nucleosome histone etch3 chya vegvegalya pratinvar houu shakatat.
bhrun mool peshi aanee vikas.
bivalent chromatin kshetra heey bhrun stame (ess) peshinmadhye aadhaltat aanee peshinchya bhinnatet mahattvachi bhoomika bajavtat. eae. ess. peshila tyachya bhinn sthiteet thevat asatana, dii. aine. aii. chya dvigunit kshetrancha vapar peshi bhinnatela sakriy karnari vikasatmak januke shant karnyasathi keela jaato, tarr januke tayar thewali jaatat aanee sakriy honyasathi tayar thewali jaatat. jevha ess peshila vishisht peshi vanshamadhye farak karnyasathi sanket midato, tevha vibhedanasathi vishisht vikasatmak janukanchi sakriyata aavashyak asate. aavashyak asaleli vikasatmak januke sakriy kelee jaatil aanee tyaa peshi vanshasathi aavashyak nasalelya itar januke tyanchya dvigunit kshetrandvare dadapali jaatil.
dvigunit kshetranvar aadhalanari etch3keey4meey3 aanee etch3keey27meey3 chinhe bhrun mool peshi bhinn aahe qee nahee kinwa anirdisht rahate (pluripotent sthitee) heey niyantrit karatat. epigenetic khuna kahee janukanchya abhivyaktimadhye yogdan detat aanee pluripotency aanee bhinnatechya darmyan itaranchya maunat yogdan detat. etch3keey27aiimaameae3 heey guna vikasatmak niyantran janukanna dadapatat aanee peshila vegale honyapasoon rokhatat, jenekarun peshi pluripotency rakhel. jaree heey chinh vanshaniyantran janukanna dadapun takte, taree teey bhinnatevar sakriy honyasathi tyanna tayar thevate. jevha peshila vishisht prakarchya peshishi farak karnyacha sanket midato, tevha bhinnatesathi aavashyak asalelya janukanmadhun etch3keey27aiimaameae3 kadhoon takale jaeel, tarr etch3keey27aiimaameae3 nivadalelya vanshasathi anavashyak asalelya vikasatmak niyantran janukanche dadpan rakhate. bivalent chromatine nirakaran karnyachya vikasatmak niyantrit prakriyela swai/ess. aine. eff. sarkhya aii. tii. pii.-chromatin remodellerschya kriyakalapandware madat hote, jeey bivalent chromatinemadhun polycomb-gut prathine baher kadhanyasathi aii. tii. pii. chey hydrolyse karatat.
vishisht peshi vansh denyasathi etch3keey4aiimaameae3 dware niyamakancha keval vishisht upasanch sakriy keela jaeel. heey chinh vibhedanantar vikasatmak niyamakanna sakriy karate aanee vibhedanyasathi aavashyak januke adhik karyaksham banavate. sakriy etch3keey4meey3 chinh asane heey pratilekhan dabkanna mage hatvoon aanee dadapshahi dii. aine. aii. methylation rokhoon janukanna kayamche shant honyapasoon sanrakshn karate.
ekada peshi eka vishisht prakarchya peshishi bhinn jhaali qee tyateel keval eka chinh chromatineshy sambandhit rahate.
chhap padane.
chhap hii eka ashee prakriya aahe jyadvare eka palak elil shant kele jaate tarr dusya palkakadoon elil vyakt kele jaate. manvi "jee. aar. bii. 10" januk chhapil januk abhivyakti darshavate aanee undaranmadhye, hii chhapil jee. aar. bii. 10 abhivyakti dvigunit chromatinechya upasthitimule saksham hote. undaranmadhil jee. aar. bii. 10 janukamadhye dvigunit kshetra asate jeey etch3keey4meey3 aanee etch3keey27meey3 badalancha vapar eka palkankadun januke vyakt karnyasathi sadhan mhanoon karate tarr dusare shant hote. yamule vishisht uutinmadhye keval ekach palkadware januk vyakt karata yete. bahutek sharirik uutinmadhye, jee. aar. bii. 10 januk heey matechya elilmadhun vyakt kele jaate, mendu vagalata jethe teey pityachya elilmadhun vyakt kele jaate. mendu vagalata serve uutinmadhye teey shant thevanyasathi janukachya pitrutvachya eleelvar etch3keey4meey3 aanee etch3keey27meey3 chinhe vaparali jaatat. menduchya uutinmadhil janukanchya matechya eleelvar samaan methylation chinhe vaparali jaatat. jevha januke vyakt kelee jaat asatat tevha dvigunit kshetratun etch3keey27aiimaameae3 dadapshahi chinh kadhale jaate.