
admuts 7

thrombospondin motif 7 (edamts 7) saha vighatan aanee metalloproteinase heey eka enzyme aahe jeey manavanmadhye gunasutra 15 vareel "edamts 7" janukadware encode kele jaate. teey anek ootee aanee peshinchya prakaranmadhye sarvatra vyakt kele jaate. heey enzyme upasthi oligomeric matricks prathinanchya (comp) hasachya hasala utprerit karate. edamts 7 haah karkarog aanee sandhivatashi anek prakarchya uutinmadhye sambandhit aahe. edamts 7" janukamadhye coronary dhamani rogachya vadhiv jokhamishi sambandhit 27 snapespacky eka dekhil aahe.
rachana.
januk.
edamts 7" januk 15q24.2 yaa pattyavar gunasutra 15 varr rahate aanee tyat 25 exon asatat.
prathine.
heey 1686-emino acid prathine edamts kutumbatil aahet aanee manavanmadhye dnyat asalelya 19 sadasyanpaiki eka aahe. edamts prathine mhanoon, edamts 7 madhye samayik proteinage kshetra aanee eka purak kshetra asate. proteinase kshetra pudhe signal peptide, prodoman, metalloproteinase kshetra aanee vighatanasarkhya kshetramadhye vibhagale jaau shakate. visheshtah, metalloproteinase domenmadhye utprerak zink aayan (zdn2 +) bandhanyasathi tyachya bandhanyachya thikani cysteine-switch rachana asate. yaa kshetrasathi chaar hydrogen bandh daata sthale aanee teen hydrogen bandh sweekarak sthale asalele pharmacophore model prastavit karnyat aale hote. proteinase kshetrachya ulat, sahayyak kshetra edamts prathinannusar badalate aanee tyat kitihi thrombospondin (tii. ess. pii.) prakar 1 rachana, eka cysteine-samruddha aanee spacer kshetra aanee vishisht edamts prathinansathi vishisht itar kshetrancha samavesh asato. edamts 7 madhye visheshtah 8 tii. ess. pii. prakar 1 rachana asatat, jyaa tyachya spacer kshetrasah, bahyakoshikiy matricks prathinanchya ghatt parasparsanvadat sahbhagi hotat.
karya.
admuts 7 heey yeastchya done-sankarit padadyamadhye compchya epidermal groth factor (eae. jee. eff.) kshetracha vapar karoon bett mhanoon olakhale gele. metalloproteinase mhanoon, edamts7 heey comp degradationsathi tyachya proteolytic karyala utprerit karnyasathi zdn2 + chaa vapar karate.
raktavahinyansambandhi gulgulit snayu peshimadhye (vhee. ess. emm. see.), edamts 7 vhee. ess. emm. see. sthalantarat madhyasthi karate, jeey atherosclerosis aanee restenosischya vikasadarmyan aavashyak bhoomika bajavate. ell. dii. ell. aar.-/-aanee epo-/-hyperlipidemic maus models yaa donhimadhye edamts 7 chee kamatarata atherosclerotic jakhamanchi nirmiti lakshaniyaritya qamee karate; shivay, edamts 7-/-mausmadhil wire-dukhapati prayoganmadhye neontima nirmiti qamee jhalyache disun yete. edamts 7 aanee atherosclerosischa sambandh asey suchavato qee edamts 7 chaa pratibandh manavanmadhye atheroprotective asava.
vaidyakeey mahatva.
vishisht mirna aanee edamts 7 chya abhivyaktichya patalimadhil nakaratmak parasparsambandh samanya uutinmadhye disun yeto parantu rogachya uutinmadhye nahee, jeey rogachya sthiteet badallela mirna-lakshya parasparkriya soochit karate. tyanusar, yaa mirna aanee edamts 7 chey abhivyakti profile karkarog aanee liken playnus samanya uutinpasoon vegale karnyasathi upayukt nidan sadhane asoo shakatat. edamts 7 heey eka anumanit oncogene mhanoon dekhil olakhale gele aahe aanee keval ashiyai lokanmadhye utparivartit jhalyache nondavale gele aahe, jyache hepatocellular carcinomachya pratibandh aanee upcharanvar parinam houu shakatat. yavyatirikt, sandhivatachya rogjananamadhye edamts 7 mahattvapoorn bhoomika bajavate. udaharanarth, eff. jee. eff. 2/pii. 65/miir-105/runex 2/edamts aksh haah austeoarthritis (oo. aii.) rogjananamadhye sameel asalyache sangitale jaate. visheshtah, edamts7 haah oo. aii. chya rogjananamadhye tumour necrosis factor (tii. aine. eff.)-α saha sakaratmak abhipray loop tayar karato.
clinical marker.
genome-wide association abhyasanni coronary dhamani rogasathi edamts 7 heey jokhamiche sthan mhanoon olakhale. edamts 7 bandhansthalachya vargikaranavar abhyas kele gele aahet, jeey coronary dhamani rogasathi naveen upcharatmak lakshya vikasit karnyachya dishene pahile paul mhanoon kaam karoo shakatat. edamts 7 madheel ess. aine. pii. saha coronary dhamani calcificationsathi mahattvapoorn sambandh dekhil hispanixmadhye aadhalale aahet. yavyatirikt, admuts 7 janukasah 27 lokinchya sanyojanavar aadharit bahu-kendrit anuvanshik jokhim gunank abhyasat, ghatana aanee varanvar honanya coronary dhamani rogachya ghatana yaa donhisathi vadhalela dhoka asalelya vyaktinchi olakh patali, tasech stattin therapicha vardhit vaidyakeey laabh. haah abhyas samudayik samooh abhyasavar (malmo aahar aanee karkarog abhyas) aanee prathamik pratibandh samoohanchya (jupiter aanee escott) aanee duyyam pratibandh samoohanchya (kalji ghya aanee teey siddha qaraa-vel 22) chaar atirikt yadruchchik niyantrit chachanyanvar aadharit hota.