
ell-ornithin aine5 monoxygenase

ell-ornithin aine5 monoxygenase (eae. see. <aay. dii. 1> kinwa eae. see. <aay. dii. 2>) heey eka enzyme aahe jeey khalilpaiki eka rasayanik pratikriya utprerit karateh ell-ornithin + naduff + oo2 sootra _ 1 aine (5)-hydroxy-ell-ornithin + nadp + + etch2oo
ell-ornithin + nadd (pii) etch + oo2 sootra _ 1 aine (5)-hydroxy-ell-ornithin + nadd (pii) + + etch2oo yaa enzymeche teen legands ell-ornithin (thurr), phaid (cofactor) aanee naduff kinwa nadd (pii) etch (cofactor aanee electron daata) aahet.
enzymeche vargikaran.
ell-ornithin aine5 monoxygenesche vargikaran done eae. see. sankhyankhali kele jaate-ec1.14.13.195 aanee ec 1.14.13.196. pahila kramank, 1, enzymela oxidoriductase mhanoon olakhato. tyanantarche 14 heey enzyme "aanvik oxygencha samavesh kinwa ghat karoon, jodidar datyanvar" karya karate yaa vastusthiticha sandarbh dete. 13 heey enzyme olakhate qee teey eka daata mhanoon naad kinwa naad (pii) echcha vapar karatat, tarr oxygencha eka anoo dusya anoomadhye samavisht karatat. mhanunach yaa enzymesathi done eae. see. sankhya aahet-eka mhanje daata mhanoon nadfcha sandarbh dett asalelya 195 saha samapt hote, tarr 196 mhanje daata mhanoon naad (pii) etch.
rachana.
ell-ornithin aine5 monoxygenase hii oxidoriductase rossman fold trutiyak rachana swikarte jee phaid aanee nadapy cofactorla bandhate.
yaa vargatil enzymesasathi 'espergillus fumigates' pasoon sphatikshastriy sanrachana sodavalya gelya aahet. yaa sanrachana sanrachanatmak badal pratibimbit karatat jeey enzyme ornithin aanee nadpiece legandschya sanyojananna bandhate tevha hotat. aii. eff. 293 yaa tanasathi atirikt sanrachana dekhil sodavalya gelya aahet. yaa sanrachana vegvegalya redox aanee bandhan sthitee pratibimbit karatat. khaleel taktyat yaa sphatik sanrachananche thodakyat varnan kele aaheh
aaa madhye. fumigates yaa enzymela 'aii. eff. sida' asey naav dile gele aahe, jeey cyderophore biosynthesis prathin aaa sathee aahe. ornithin (thurr), phaid (cofactor) aanee nadd (pii) etch (cofactor aanee electron daata) yasathi tyachi teen kshetre aahet. heey enzyme eka homotetrammer aahe.
aine-hydroxylating flavin-yukt monoxygenase (aine. emm. oo.) enzymes, jase qee ell-ornithin sarkhya prathamik elephatic aminechya nucleophilic terminal amine gatanna lakshya karatat. heey enzyme bahustareey oxidative yantranedvare karya karate jyamadhye see4aii-hydroperoxiflavin madhyavarti asate. sida heey madhyavarti sthir karate aanee utprerak chakrachya urvarit kalat nadapy + baddh thevate kaaran madhyavarti sthirikaranasathi teey aavashyak aahe. mukhya sakhali aanee avasheshanmadhye asalele nicotinamide-raiboj bhag aanee etch-bandh heey ell-ornithin alfa carbonla asha prakare sthan detat qee tyachya bajuchya sakhalitil amino gatala see4aii-(hydro) peroxiflavindware hydroxylate kele jaau shakate. itar anek aine. emm. oo. ess. chya ulat, aaa. fumigates sida ornithinavar katekorpane karya karate. arginineshee honanya parasparsanvadamule flavin aanee oxygenmadhil parasparsanvad vadhato.
sakriy sanketsthal pratyek upghatkavaril teen kshetranmadhil interfacevar eka fatyat sthit aahe. sidala vishrantichi sthitee (6x0h) asate jyamadhye ell-ornithin kinwa naad (p) etch donhi bandhalele nasate. yaa vishrantichya sthiteet eka 'out' sakriy jaaga aahe jee phaid isoaloxazine mothya paribhramananmule aanee tyrosine loopchya 10-Â halchalinmule hote. ektar flavin qamee karane kinwa nadd (pii) etch bandhan sakriy sitela "inn" sanrachana (6x0i) kadey chalavate.
ell-ornithinane santrupt jhalyavar sida vishisht gatishastra darshavite. nadf aanee nadhchya uchch sandratemule pratibandh hoto. nadhchya tulanet nadhchya utprerak karyakshamatet 8 putt vaadh jhaali aahe. nadapy + haah nadufchya sandarbhat eka spardhatmak avarodhak aahe.
karya.
heey enzyme mothya pramanavar pasarlele aahe, visheshtah eukeriotsmadhye, burshi, metazoa, protista, viridiplante, choanophlagelets aanee ethiosporiencemadhye aadhalate. jivanunmadhye, too kutzneria ess. pii. madhye aadhalato. 744, aanee 'seudomonas' eruginosa 'madheel ornithin hydroxylase rachana sarkhich aahe aanee 41 takke amino acidchi samanata' aaa 'shhee aahe. nidulance ".
espergillus nedulance" sarkhya rogkarak nasalelya burshinmadhye aadhalanyavyatirikt, teey "espergillus fumigates", "botritis cineria", "fugerium auxisporum", "magnaporthe oriza", "sclerotenia scleroteorum", "spizelomyces punctats" aanee "eustilago medis" yasarkhya anek burshijanya rogjankanmadhye dekhil aadhalate.
aaa madhye. fumigates, "heey flavoprotein mhanoon vargikrut kele jaate kaaran phaid haah eka sahghatak aahe. heey ferrichrome cyderophores triacetylphusarinine aanee despherrifericrosinch jaivasanshleshanat ell-ornithinchya pheda aanee naduff-dependent hydroxylationla utprerit karate. heey pramukhyane loh-maryadit paristhitit tayar kele jaate. vishanunsathi cyderophores dekhil mahatvache aahet.
kutzneria ess. pii. madhye. 744, heey enzyme piperazetchya jaivasanshleshanat guntalele aahe, jeey kutzneride pratijantu pratijaivikanchya jaivasanshleshanat yogdan dete.