
etch. etch.-sweet

etch. etch.-suut heey sanvedanshil prathine anukram shodhanyasathiche eka mukt-srot software package aahe. tyat asey karyakram aahet jeey prathine anukram detabasemadhye samaan prathine anukram shodhu shakatat. anukram shodh heey aadhunik jivashastratil eka manak sadhan aahe jyadvare samaan anukram asalelya prathinanchya karyanmadhun adnyat prathinanchya karyacha andaj lavala jaau shakato. echaech search aanee hhablit heey packagemadheel done mukhya program aahet aanee tyachya shodh karyasathi pravesh bindu aahet, nantarche eka jalad punaravrutti aahe. etch. etch. pii. aar. dii. haah prathinanchya sanrachanechya andajasathicha eka online server aahe joou etch. etch.-sootmadhun samarupata mahitee vaparato.
etch. etch.-suut lapalelya markov modelscha (etch. emm. emm. ess.) vapar karoon anukram shodhate. heey naav hyamule aale aahe qee teey humm-humm sanrekhan karate. prathine anukram julanisathi sarvat lokpriy paddhatinpaiki, googal scholarchya matey, programs ekoon 5000 patinni uddhrut kele gele aahet.
parshvabhoomi.
jivanachya serve prakriyanmadhye prathine madhyavarti bhoomika bajavtat. peshinmadhil aanvik prakriya samajoon ghenyasathi tyanna samajoon ghene heey kendrasthani aahe. roganche mool samajoon ghenyasathi heey visheshtah mahatvache aahe. parantu andaje 20,000 manvi prathinanchya mothya bhagasathi sanrachana aanee karye adnyat rahatat. anek jivanu, bekarche yeast, falanche mashe, zebra maase kinwa under yasarkhya aadarsh jivanmadhye anek prathinanchi tapasani kelee gelee aahe, jyasathi prayog anekada manvi peshinpeksha adhik sahajpane kele jaau shakatat. prathinanche karya, rachana kinwa itar gunadharmancha andaj lavnyasathi jyasathi keval amino acidcha kram dnyat aahe, prathinanchya kramachi tulana sarvajanik detabasemadhil itar prathinanchya kramanshi kelee jaate. puresa samaan kram asalele prathine aadhalalyas, donhi prathine utkrantishi sambandhit asanyachi shakyata aahe ("samaroop"). asha paristhitit, teey samaan sanrachana aanee karye samayik karanyachi shakyata aahe. mhanoon, jarr puresa samaan kram asalele aanee dnyat karye aanee/kinwa rachana asalele prathine anukram shodhadvare shodhale jaau shakatat, tarr adnyat prathinechi karye, rachana aanee kshetra rachanecha andaj lavala jaau shakato. asha andajanmule lakshyit pramanikaran prayogandware karya kinwa rachana nishchit karane mothya pramanat sulabh hote.
adnyat prathinanchya karyala tyachya kramane samajoon ghenyasathi jivshastradnyankadun varanvar anukram shodh ghetale jaatat. yaa uddeshasathi, prathinanchya kramachi tulana sarvajanik detabasemadhil itar prathinanchya kramashi kelee jaate aanee tyache karya sarvat samaan kramapasoon kadhale jaate. byavachada, asha shodhat annotated functions konatehi anukram aadhalat naheet. yaa prakaranat, adhik dursthapane sambandhit prathine kinwa prathine kutumbe olakhanyasathi adhik sanvedanshil paddhati aavashyak aahet. yaa sambandhanvarun, prathinanchi karye, rachana aanee kshetra rachanebaddalachya gruhitkancha andaj lavala jaau shakato. hhsarch detabesdware prathinanchya kramane shodh karate. etch. etch. pii. aar. dii. server aanee etch. etch.-suut software package prathine deta banq, tasech interpro, pii. eff. aii. emm., kog aanee scop databases yasarkhya anek lokpriy, niyamitpane adyayavat databases detat.
algoridam.
prathine shodhanyasathi aadhunik sanvedanshil paddhati anukram profilecha vapar karatat. tyancha vapar anukramachi profileshy tulana karnyasathi kinwa etch. etch.-sootsarkhya adhik pragat prakarananmadhye profilemadhye julanyasathi keela jaau shakato. profile aanee sanrekhan heey swatah julyanmadhun ghetale jaatat, udaharanarth pii. ess. aay.-blast kinwa etch. etch. bii. ell. tii. chaa vapar karoon. sthitee-vishisht gunankan matricks (pii. ess. ess. emm.) profilemadhye prashna anukramat pratyek sthanasathi 20 amino esidsathi samanata gunank asato. profile heey ekadhik anukram sanrekhanmadhun (emm. ess. aii. ess.) ghetale jaatat, jyamadhye sambandhit prathine ekatra (sanrekhit) lihili jaatat, jenekarun pratyek sthanavaril amino aesidchya varanvartecha arth naveen sambandhit prathinanmadhil amino aesidchya sambhavyata mhanoon lavala jaau shakato aanee tyacha vapar "samanata guna" midvinyasathi keela jaau shakato. kaaran profilemadhye ekach anukramapeksha (udaa.jee. sthitee-vishisht patalivaril sanwardhan), profile-profile tulana paddhati, blast sarkhya anukram-anukram tulana paddhati kinwa pii. ess. aay.-blast sarkhya profile-anukram tulana paddhatinpeksha adhik shaktishali aahet.
etch. etch. pii. aar. dii. aanee etch. etch. search heey profile hiddon markov models (etch. emm. emm. ess.) dware kweri aanee databases prathinanche pratinidhitva karatat, jeey pii. ess. ess. emm. sequence profilecha vistar aahe jeey sthan-vishisht amino acid incersion aanee delete frequency dekhil nondavate. echaech search haah etch. emm. emm. ess. chaa databases quaries shodhato. etch. emm. emm. ess. chya pratyaksh detabesdware shodh suru karnyapurvi, etch. etch. search/etch. etch. pii. aar. dii. etch. etch. blitt programcha vapar karoon kweri sequence/emm. ess. aii. shhee sambandhit sequencechi ekadhik sequence sanrekhan tayar karate. yaa sanrekhanatun, eka profile etch. emm. emm. mojale jaate. detabasemadhye etch. emm. emm. asatat jeey pii. ess. aay.-blastcha vapar karoon tyach paddhatine purvaniyojit kele jaatat. etch. etch. pii. aar. dii. aanee etch. etch. search. chey utpadan hii databases julyanchi (eae-moolye aanee khyan sambandhasathi sambhavyatesah) aanee jodiwar prashna-databases anukram sanrekhanchi kramvarit dileli yadee aahe.
2001 pasoon etch. etch.-sweetcha eka bhag asalelya etch. etch. blits, ekach kweri sequence kinwa emm. ess. aii. pasoon suru houn uchch-gunvattechya ekadhik anukram sanrekhan (emm. ess. aii. ess.) tayar karatat. pii. ess. aay.-blastpramanech, heey punaravrutti mhanoon karya karate, mageel fereet aadhalalele parinam jodoon varanvar naveen kweri profile tayar karate. heey prathine anukram detabespasoon prapt jhalelya purv-nirmit etch. emm. emm. detabesashi julate, pratyek sambandhit prathinanchya "samooh" chey pratinidhitva karate. etch. etch. bii. ell. tii. chya babatit, asha julanya etch. emm. emm.-etch. emm. emm. profilechya staravar kelya jaatat, jyamule atirikt sanvedansheelata milate. tyachya purv-galanamule lakho etch. emm. emm. qamee hotat aanee teey tyanchya kahee hajaranshi julatat, asha prakare mand etch. emm. emm.-etch. emm. emm. tulana prakriyes gatee milate.
etch. etch.-sootmadhye anek purv-nirmit profile etch. emm. emm. aahet, jeey etch. etch. blitt aanee etch. etch. search vaparoon shodhale jaau shakatat, tyapaiki uniprot detabesachi eka samoohit aavrutti, dnyat sanrachanansah prathinanchya prathin deta bankechi, pii. eff. aii. emm. prathin kutumb sanrekhananchi, scop structural prathin domenchi aanee itar anek.
anuprayog.
etch. etch. pii. aar. dii. aanee etch. etch. sarchchya anuprayoganmadhye prathinanchya sanrachanecha andaj, jatil sanrachanecha andaj, karyacha andaj, kshetracha andaj, kshetra seema andaj aanee prathinanche utkranti vargikaran yancha samavesh hoto.
echechsarchcha vapar anekada samarupata modelingsathi keela jaato, mhanje kweri prathinanchya sanrachaneche model tayar karnyasathi jyasathi fakt kram dnyat aaheh tyaa uddeshasathi, prathin deta banksarkhya dnyat sanrachanansah prathinancha databases kweri prathinanpramanech "template" prathinansathi shodhala jaato. jarr ashee namuna prathine aadhalali tarr namuna prathine kramasah prashnachya jodiwar kram sanrekhananusar swarasya asalelya prathinachya sanrachanecha andaj lavala jaau shakato. udaharanarth, sodavalelya 3dii sanrachanesah prathinanchya pii. dii. bii. detabesdware shodh ghenyasathi kahee minite lagatat. jarr pdb detabasemadhye dnyat sanrachanechya prathinanshi (eka "template") lakshaniy julani aadhalali, tarr etch. etch. pii. aar. dii. vaparkartyala jodiwar prashna-template sanrekhanapasun suruvat karoon, modeller softwarecha vapar karoon samarupata model tayar karanyachi parvanagi dete.
andh prathin sanrachanechya andaj prayogansathi, etch. etch. pii. aar. dii. serverla casp 7,8 aanee 9 darmyan sarvottam sarvharmadhye sthan denyat aale aahe. casp 9 madhye, etch. etch. preda, bii aanee see heey template-aadharit modelingmadhye bhag ghenanya 81 svayanchalit rachana andaj sarvharpaiki 1,2 aanee 3 rancover hote aanee serve 147 lakshyanvar 6,7,8 vya kramankavar hote, tarr sarvottam 20 sarvharpeksha barech vegwan hote. casp8 madhye, etch. etch. pii. aar. dii. serve lakshyanvar 7vya kramankavar aanee ekal domain prathinanchya upasanchavar 2yyaa kramankavar hote, tarr tarihi teey avval kramankachya sarvharpeksha 50 putt jaast vegwan hote.
samagri.
echaech-search aanee hhablit vyatirikt, echaech-sootmadhye swaroop rupantaran, emm. ess. aii. ess. chey galan, profile etch. emm. emm. ess. chee nirmiti, emm. ess. aii. ess. madhye duyyam sanrachanechya andajanchi bharr, program outputmadhun sanrekhan kadhane aanee sanukoolit detabesachi nirmiti yasathi program aanee pearl scripts asatat.
etch. etch.-sweetchya aavrutti 3 madheel vector soochanancha vapar karoon etch. etch. blitt aanee etch. etch. sarchchya etch. emm. emm.-etch. emm. emm. sanrekhan algoridamla lakshaniy gatee denyat aalee.