caprom

caprom mhanje serve cellular molecular capron aanee qoo-capron prathinancha samooh, jeey mool prathinanche folding aanee karya sunishchit karnyasathi, ektrit-sambandhit proteotoxicity aanee parinami prathinanche karya qamee hone kinwa neurodegenerative rog alzheimer, huntington kinwa parkinson rog yasarkhya prathinanchya chukichya folding-rogancha virodh karnyasathi tasech cellular proteostasis aanee proteom santulanache sanrakshn karnyasathi chukichya folding prathine kinwa folding intermediateschya prathine foldingla madat karatat.
etch. ess. pii. 90 saha-capron saha-capron chey daun-regulation heey cystic fibrosismadhye see. eff. tii. aar. chya chukichya foldingla vachavate, asey nishkarsh kadhalyavar, sampoorn capron folding vatavaran kinwa "caprom" chey varnan karnyasathi, caprom haah shabd pratham 2006 madhye balch aanee aanee selmadhil prakashanat tayar keela hota. 2014 madhye, breham aanee aanee manvi vruddhatvachya mendut aanee neurodegenerative rog asalelya rugnanchya mendut ~ 300 manvi chepron aanee saha-cheparoncha samavesh asalelya sampoorn manvi cheparomchya abhivyakti gatishilatecha paddhatshirpane abhyas keela. krumee aanee manvi peshinmadhil cheprom-wide functional aar. aine. aii. interference (aar. aine. aii.) vikshobh prayognsah ekikaranamule vruddhatva aanee neurodegenerative roganmadhye proteostasische sanrakshn sanrakshn cheprom up-jaalyachi olakh patali.
alikadech, eka sarvasamaveshak sahitya sarvekshanane 2000 saalee manvi januk kram prakashit jhalyapasun lahan prani pratikruti pranalinmadhye paddhatshir abhyasasathi sahityacha aadhava ghetala aanee vyapak manvi pratikrutimadhye pratinidhitva kelelya mothya sankhyepaiki proteotoxicitychya tyaa pramukh pratikruti parivartakanche anavaran karnyasathi pratikruti pranalinchya samarthyavar prakash takala, jeey pratikruti karyakshamatechya upcharatmak niyamanasathi uddishte aanee dhorane kalavoo shakatat.
2016 madhye, rodina aanee itaranni lihilela 'nisarg' lekh. keval karkarogachya peshinmadhye peshinmadhye astitvat asalelya capromchya jaalyacha sandarbh denyasathi epichperom hii eka naveen sandnya sadar kelee. adhik visheshtah, yaa jaalyatil kahee pramukh ghatakanmadhye ushma-shock prathine 90 (etch. ess. pii. 90) aanee ushma-shock cognet prathine 70 (etch. ess. see. 70) yancha samavesh hoto. karkarogachya peshinmadhye, samanya, nirogi peshinmadhye, jethe heey caparoms mubalak pramanat aanee swatahun karyasheel asatat, tyaulat, caparomsmadhil parasparsanvadatil badalanmule caparoms, saha-caparoms aanee sambandhit saha-ghatakanche jaale tayar hote. jeey aadhalun aale aahe teey asey aahe qee hypoxia aanee ushnatesah tanavashi julavun ghetana cancerachya peshinsathi tikoon rahnyasathi chapromsmadhil heey majboot jaale eka yantrana aahe. etch. ess. pii. 90 yaa lahan renuche, puu-etch. 71 heey, jevha teey atyant ekatmik jatil swarupat asate, mhanje epichperom, tevha etch. ess. pii. 90 laa pradhanya bandhan asalyache aadhalun aale aahe.

