
phosphorybocylaminoidasymiclolisasidemimisalisamisasamisamisamisamisamisaasamisamisamisamisaaamisasasamimisaamisasamimisaaamimisasaaaasasamimisaaasasamisamisamimisaaamisaasaaaasasaamisisasaasasamimisa synthase

molecular biologyil, saikar srishtikkunnathinulla prathikaranatthe uthejippikkunna oru ensaimaanu protein domaine saikar synthase. ensimologyil, eee ensime phosphorybocylaminoidalismicalimimisalisisamisamisamisamisamisamisamisamisaamisamisamisamilaaamisasamisamisamisamisamisamisaamisasamilaaaaamilaamisamisamisamisamisaamisaamisaaasamisamisasamisamisamisa synthase () ennum ariyappedunnu. raasapravarthanathe uthejippikkunna oru ensaimaanu ithu.
eee ensaiminte 3 substrateukal eiii. tii. pii, 5-amino-1-(5-phospho-dii-ribosil) imidasol-4-carboxylate, ell-aspaarttett ennivayaanu, athesamayam athinte 3 uthppannangal eiii. dii. pii, phoosphett, (kall)-2-[5-amino-1-(5-phospho-dii-ribosil) imidasol-4-carboxamido] sasinettu ennivayaanu.
eee ensime ligasukalude kudumbatthil pedunnu, kaarban-naitrajan bondukal assid-dii-amino-assid ligasukalaayi (pepttaid sinthaasukal) roopappeduthunnu. eee ensime klaasinte chittayaya peru 5-amino-1-(5-phospho-dii-ribosil) imidasol-4-carboxylate ell-aspaarttett ligase (eiii. dii. pii-forming) ennaanu. eee ensime purine mettabolisatthil pankedukkunnu.
eee prathyeka protein kudumbatthinu valia praadhaanyamund, kaaranam ithu jeevithathinte moonnu mekhalakalilum kaanapedunnu. purine jaivasamshleshanathinte paathayile ezhaamathe ghattamaanith. oorjja upapachayam, dna synthesis ennivayil earppettirikkunnathil purinukal ellah koshangalkkum pradhaanamaan. koodaathe, purine biosynthesis paathayekkurichulla patanam chemotherapic marunnukalude vikasanathilekku nayichekkaamennathinaal avaa shaasthreeya gaveshakarkk prathyeka thaalpparyamullavayaanu. mikka arbudangalkkum adenine nucleotideukalkku oru rakshaamaarggam illaathathum poornnamaayum saikar paathaye ashrayikkunnathum ithinu kaaranamaan.
protein domaine.
yookkariyottukal, bakteeriyakal, archaea ennivayil eee protein domaine kaanapedunnu. oorjja upapachayam, dna synthesis ennivaykku sahayikkunna purine biosynthesis paathayile oru ghattathe uthejippikkunnathil ithu jeevajaalangalkk athyanthaapekshithamaanu.
protein domaine pravartthanam.
bakteeriyakalilum sasyangalilum eee protein domaine saikkarinte samanvayathe maathrame uthejippikkunnulla. ennirunnaalum, sasthanikalil ithu phosphorybocylaminoidal carboxylase (aircy) pravartthanatheyum uthejippikkunnu.
protein domaine ghadana.
eee prathyeka protein 8 samana upavibhagangal chernna oru okdaamaraanu. oro monomerilum oru central domain sii-terminal alfa helix adangiyirikkunnu. kendra domainil ulppedunnu
moonnu alfa helixukalaal chuttapetta anchu-stranded samanthara beetta sheettinte
sheettinte oru vashath rund alfa helisukalum maruvashathu moonnu paalikalulla (alfa beetta alfa) sandwich roopappedunnu.
gadanaaparamaaya padanangal.
2007 avasaanathode, eee klaas ensaimukalkkaayi pii. dii. bii accession kodukal,,,,,,,,,,,, enniva upayogichu 10 gadanakal pariharichu.

