kiya 408

jeane.
sthalavum savisheshathakalum.
rund enn. sii. bii. aii jeenukale layippikkukayum sequence ovarlaappu illaatha onniladhikam proteinukal uthpaadippikkukayum cheiyunnathinaal "sankeernamaaya locus" aayi kanakkaakkappedunna chr 6orf174 enna chromosomil kiya 408 enna jeane sthithicheyyunnu. ithinu 6 exonukalundu, 4 ennam overlapping allaathathum 2 kaasatt exonukalumaanu. c6orf174 694 amino aasidukalkk neelam. 
mrna shreniyil 8123 nucleodideukalundu. c6orf174-ll 20 vyathyastha jidi-eji intronukal adangiyirikkunnu, athinte transcriptionil 14 vyathyastha emrnkal utppaadippikkaan kazhiyum, avayil moonnu poornnamaayum splis cheyyaatha roopangalaanu. ithinu ezhu isophomukalundu. kiya 408-nte jenecard chuvade chithrappeduthiyirikkunnu.
vakabhedangalum aparanaamangalum.
kiya 408 nuu kuranjathu 11 splicide variants.1 aparanaamangalund, avayil c6orf174andkia0408, flj43995, rp3-403a15.2, dj403a15.3, c6orf174, loock 9729, jajar, barpoybi, gyperbu.1 enniva ulppedunnu, ithu saangalppika protein protein, loock9729, saangalppika protein loock 387104.1 uniprotcub ithine k0408 _ human, q6su52 ennu paraamarsikkunnu.
aavishkaaram.
thalachorilum kozhuppilum shwaasakosha koshangalilum kiya 408 ettavum kooduthal prakadippikkunnathaayi kaanapedunnu. kiya 408 hippocampasumaayi bandhappettirikkunnu, ithu praadhamikamaayi hormonukal purathuvidunnathinum shareera thaapanila niyanthrikkunnathinum sahayikkunnu. manushyaril, eee jeane leukositeukal, hypothalamous, glioblastoma koshangal, precondrocyteukal, plaasantal sidi 14 + bheeman koshangal, eestrajan risapttar alfa-silenced mcf 7 stanarbudam elikalil, carbohydrate-vee protein hydrocylate bhakshanagal kazhikkunna elikalil uyarnna alavil kiya 408 prakadippikkunnu.
glioblastoma seudopaliseding koshangal necrosisumaayi bandhappettirikkunnu. randaamathe kanakkukale adisthaanamaakki, seudopaliseding koshangale apekshichu tumour koshangalilanu kiya 408 kooduthalaayi prakadippikkunnathennu thonnunnu.
aavishkaarathinte niyanthranam.
expassyile sumo-sumoilation pravachanamanusarichu, sumoilation undakanulla uyarnna saadhyathayulla naalu roopangal undennu thonnunnu. kiya 408-nuu serin 386-ll pravachikkappedunna oru oo-glycosylation saitt undu. jeeninu dhaaraalam pravachikkappedunna phosphorylation saittukalund.
protein.
kiya 408-ll 694 amino aasidukalum 79.2 kilodal tanmatra bhaaravumund. 12.0 sathamaanam proteinukalil saraashariyekkaal kooduthal serin adangiyittundu. eee phalangal soochippikkunnathu oru neutral piechil, ente protein kooduthal adisthaanamaayirikkumennum. expassyil ninnu shekharicha thelivukal soochippikkunnathu kiya 408 laayaniyil ulppettirikkaam ennaanu. kiya 408-nte moonnaam ghadana pradhaanamaayum churunda-churunda pradeshangal ulkkollunnu. kiya 408 nucleusil kaanappedunnundennu valare urappode pravachikkappedunnu. oru aashayaparamaaya vivarthanam eee pejil ulppeduthiyittundu.
parasparaprathikarana proteinukal.
kiya 408-ll motham 42 parasparabandhitha proteinukalundu.
oorthologukal.
sasthanikal muthal pakshikal vare orthologue space vyaapichukidakkunnu. paaralogukalilla.
ellah pakshikalkkum jeane dairkhyam,% aidantitti,% saamyam ennivayil valare kurachu vyathyaasame undaayirunnulloo. jeane undaayirunna rund aamakalum aaa pradeshangalil samanamaayirunnu. lemur kurangum ozhikeyulla ellah sasthanikalkkum ekadesham ore jeane dairkhyam,% aidantitti,% saamyam ennivayundaayirunnu. lemur kurangum parasparam vyathyasthamaayirunnu.
manushyan eliyum kiya 408 umm 53.531% samaanavum samanamaaya 149 sthaanangalullathumaanu. sii-terminasil mousil kaanaatha oru valia pradeshavum enn-terminasil kaanaatha mattoru cheria bhaagavumund. kooduthal sankeernamaaya vyakthikalayi maattunnathinaayi kooduthal jeenukalude thettaaya vikasanathinte parinamaparamaaya adayaalamaayirikkaam ithu. rund illaathaakkalukalkkum munbum sheshavumulla pradeshangal valareyadhikam samrakshikkappedunnu, athinaal iva jeeninte valare nirnaayaka pradesangalaanu.
klinikkal praadhaanyam.
kiya 408 thalachoril valareyadhikam prakadippikkappedunnu, ennaal stanam, vrishanangal, kannu, vrukka, tii-lymphocyteukal ennivayude tissuevilum mattu 50 ladhikam <aii. dii. 1> lum ithu thaazhepparayunna klinikkal savisheshathakal thammilulla thaarathamyangalil appregulate cheythathayi kandethithi puthiya tumour/puthiya tumour illa, pathologic emm 1/emm 0, pepparile pattikayile <aii. dii 2> nte saannidhyam allengil abhavam enniva eathu savisheshathakalumaayi appregulation bandhappettirikkunnave vyakthamalla. eee protein "paarambarya rogam" soochippikkunna mutationukalkkaayi pareekshikkam. eathu paarambarya rogangalkkaan ithu pareekshikkaan kazhiyuka ennathinekkurichu prathyeka vivarangalonnum nalkiyittilla. kiya 408 jeane traanskripttukalude oru pattikayude bhagamaanu...avarude avishkaara nilavaaram praayavumaayi kriyaathmakamaayi bandhappettirikkunnu."

