
rl4dii

manushyaril "rl4dii" jeane encode cheiyunna oru proteinaan adp-ribosilation factor polulla protein 4dii.
pravartthanam.
jidipi-binding proteinukalude edpi-ribosilation factor kudumbatthile amgamaanu edpi-ribosilation factor 4dii. rl4dii rl4eiii, rl4sii ennivayumaayi valare saamyamullathaan, oronninum nuclear localisation signal asaadhaaranamaamvidham uyarnna gwanine nucleotide vinimaya nirakkum undu. eee protein membranumaayi bandhapetta intra sellular traafikkingil oru punk vahichekkaam. eee jeenil varunna mutationukal baardett-beedel syndrome (bbs) maayi bandhappettirikkunnu.
maathrukaa jeevikal.
rl4dii fangshanekkurichulla padanatthil maathrukaa jeevikal upayogichittundu. thaalpparyamulla shaasthranjarkku rogathinte mruga maathrkakal srishtikkunnathinum vitharanam cheiyunnathinumulla uyarnna-throoput mutagenesis projectaaya anthaaraashtra nokkautt mouse kansorshyam prograaminte bhaagamaayi "rl4dtm1eiii (ucom) ibluts" ennu vilikkunna oru vyavasthaapitha nokkautt mouse line srishtichu.
illaathaakkalinte phalangal nirnnayikkaan aann, penn mrugangal oru staanderd phenotypic screenin vidheyamaayi. mutent elikalil irupathiyanchu parisodhanakal nadathukayum kaaryamaaya asaadhaaranathakal nireekshikkukayum cheythu. homocygus mutent penthumbikalil asthi daathukkalude alavu, hridayabhaaram, melinja sareerabhaaram, sidi 8-positteev, alfa-beetta memory tii sell nambar enniva kuranju. purushanmaarkk vertebral parivartthanathodoppam asaadhaaranamaaya vaariyellinte roopaghadana undaayirunnu. rund lingakkaarum dorsal therd ventricle eriyayilum hippocampal eriyayilum kuravu kaanichu.

