
bii tharam thirikkuka

eee uparithala proteinukal bacteria kosha uparithalathil tharamthirikkukayum peptidoglycanil nankooramidukayum cheiyunna membran aankar cheytha ensaimaanu sortesukal. vyathyastha tharam sortaasukalundu, oronnum vyathyastha proteinukalude koshabhithikalilekkulla nankooram uthejippikkunnu.
anubaadhayude samayat baakteeriyakalkk irumbu labhikkunnath valare pradhaanamaan, orupakshe bakteeriyakal vyapikkunnathinum rogamundaakkunnathinum aavashyamaaya ettavum pradhanappetta micro neutriyantaanu irumbu. sortez bii, 246 amino aasidukalulla polypeptideanu, koodaathe putateive n-Terminal membrane anchor umm sortesukalude tlxtc signature motifil sthithicheyyunna oru sajeeva saitt sisteenum undu.
sell membran sortez bii enpkittien motif thirichariyukayum pilartthukayum cheiyunnathilekku irumbu ettedukkal proteinukal nankooramidunnathiloode bakteeriyakale irumbu nedaan sahaayikkunnathin eee ensimeukal samarppichirikkunnave thonnunnu. ithu aii. ezz. dii. siye pakwathayulla assembly peptidoglycanumaayi bandhippikkunnu, ensime oru sell vaal sorting prathikaranatthe uthejippikkunnu, athil oru enn. ex. tii. enn motif adangiya sorting signalullah uparithala protein pilarunnu.
eee ensime sii60 peptidays kudumbatthil pedunnu.
ghadana.
srtb mothatthilulla ghadana vividha gram positteev bakteeriyakalil samrakshikkappedunnu. s-ll srtb-yude mothatthilulla ghadana. chithram kaanichirikkunnathupole ooriyasil, oru savisheshamaaya ettu strended β-barrell coor ghadanayum n-terminal attathu rund helix subdomain adangiyirikkunnu. 
srtb ghadanayil srtaic samaanamaan, ennaal esartibic kooduthal peripheral helikkukalund, ithinu oru enn-terminal helical bundle undu, koodaathe β6 num β7 num idayil oru α-helix undu. srtaumaayi thaarathamyappeduthumbol srtbyil ulla enn-terminal ekstenshan valare praadhaanyamarhikkunnu. rund terminikalum proteininte ore vashath sthaapikkunnathaayi ariyappedunnu. ithu koshatthinte uparithalathile proteente vyathyasthamaaya ooriyanteshanil kalashikkumennu vishwasikkappedunnu, ithu substrate aaksasine badhikkaan saadhyathayund.
catalis.
oru signal nxtn motif pilarnna oru uparithala proteinumaayi oru sell vaal sorting prathikaranatthe sortez bii ensime uthejippikkunnu. thalphalamaayi, proteente sii-end oru amide linkejiloode oru pentaglycin cross-bridjumaayi sahavarthithvathode gadippikkappedunnu, angane protein eyude sii-terminasine koshabhithikku tether cheiyunnu. 
ithu protein precursor moleculine enpkittien motifil vibhajikkunnu. enpkittien sorting motifinte tii, enn enniva thammilulla pepttaid boond pilarnnu oru tetrahedral asail intermediat roopappedunnu. lipid II peptidoglycan mungamiyaaya thanmaathrakalumaayi bandhapetta pentaglycin cross-bridjukalude amino grouppukal asail idanilakkaare pariharikkukayum uparithala protein lipid II umm thammil oru amide boond srishtikkukayum cheiyunna nucleophylayi pravarthikkunnathaayi karuthappedunnu.
isdc koshabhithikkullil kuzhichittirikkunnu, uparithalathil isda, isdb enniva pole sthithicheyyunnilla. haemoglobinil ninnu irumbu neekkam cheyyaan eee sisttam muzhuvan orumichu pravartthikkunnu.
jeevashasthraparamaaya punk.
clostridium deficile" anubadha polulla manushya anubaadhakalude rogakaarikalil gram positteev bakteeriyakalude uparithala proteinukal oru pradhana punk vahikkunnu. eee uparithala/pasha proteinukal hoost tissukalumaayulla bacteriayude prarambha attaachmentine madhyasthatha vahikkunnu. eee proteinukal bacteria koshabhithi peptidoglycanumaayi sahavarthithvathode bandhappettirikkunnu. kooduthal kooduthal rogakaarikal antibioticukalodu prathirodhasheshiyullavaraayil, sortaasukalude nirodhanam gram-positteev bacteria anubaadhakalkkethire oru puthiya thanthram nalkum.
srtb prathyekichum valareyadhikam shradha nedukayum oru prateeksha nalkunna lakshyamaayi amgeekarikkappedukayum gram positteev bakteeriyakalilulla athinte jeane illaathaakkunnathu gurutharamaaya viralence vaikalyangalilekku nayikkukayum cheyyum. vividha enangalil ninnulla eee srtb ensaimukalude kristtal gadanakal avayude sajeeva saittumaayi bandhippichirikkunna ligandukal/inhibittarukal upayogichu pariharichu. sajeevamaaya sthalathekkurichulla arivode, eee bacteria enangalkkethire mikacha chikilsakal vikasippikkaan kazhiyum.

