
echu. ell. eiii-eiii1

echla-eiii1 (eiii1) ennathu echla-eiii "eiii" serotype grouppinullile oru manushya leukosite aantijan serotypeanu. echla-eiii-cheyinukalude α1 upavibhaagathinte antibody thirichariyalaanu serotype nirnnayikkunnath. a1-neey sambandhichidatholam, alfa "a" shringalaye hla-a alleel group β-shringalaye b2m locus encode cheiyunnu. eee groupil nilavil oru * 01:01 aadhipathyam pulartthunnu. a1 umm a umm ardhathil eathaandu paryaayapadangalaanu. eiii1 mattevideyenkilumonni europil kooduthalaayi kaanapedunnu, vadakkupadinjaaran europile purathana janathayil pathivayi kaanapedunna oru neenda haplotypinte bhaagamaanith. ah8.1 haplotypinte pathiv gadakamaanu a1. 
eiii1 serotype posittivitti ekadesham rogaprathirodha samvidaanathinte pankaalithamundennu vishwasikkappedunna niravadhi koshajwalana rogangalumaayum avasthakalumaayum bandhappettirikkunnu. ah8.1 haplotypinullile bandham kaaranam, pala padanangalum a1 allengil a1, b8 ennivayumaayi bandham kaanichu, pinneedu klaas II reejian jeane alleelukalaaya, dr3, dq2.5 ennivayilekku association neengunnuvennu kaanikkunnu. pakarchavyaadhiyil a1 nuu enthu pankundennu vyakthamallengilum, echuaiviyile anubadha nirakkumayulla chila bandham haplotypinte a1 mekhalaykkullil bandhappettirikkunnu.
serotype.
ithuvare ellah sandarbhangalilum, echla-eiii1 rogavumaayi bandhappettirikkunnave kandethiyittundu, ennaal echla-eiii1 nirvachikkunna churukkam chilath valia haplotypile eiii1 jeeninu sameepamulla mattu jeane-allilukalumayi thaarathamyappeduthumbol pradhana janithaka apakadasaadhyathayund.
eiii1, svayam rogaprathirodha rogangal.
echl-eiii" aantijanukale aadyam vivarichathinal eiii1 serotype niravadhi rogangalumaayi bandhappettirikkunnu. hla1, bii8 enniva saadhaaranayaayi bandhippichirikkunnave kandethiyathinal 'echl-eiii8' echla-bii8 ulppeduthunnathinaayi associationukal athivegam vikasichu. dii. aarr. dablyu. 3 yude savisheshatha anusarichu, svayam rogaprathirodha apakadasaadhyatha randaam klaas mekhalayilekku neengi. 
a1-b58 haplotype (b58 prabalamaaya a1-b17) aanti-neutrophil cytoplasmic antibodiyumaayi (anca) bandhappettirikkam.
pramehathil eiii1.
type 1 prameham ozhike, eiii 1-nuu svayam rogaprathirodha rogangalumaayi nerittu bandhamullathinte bhooribhaagam thelivukalum dii. aarr 3, dii. kyu 2 jeenukalaayi bashpeekarikkappettu. type 1 prameham echla eiii1-bii8-dr3-dii kyu2 haplotypil oru vipulamaaya bandham kaanikkumbol, eee bandham echla-bii lokkasinappuram vyaapikkunnillenn thonnunnu. mattu eiii-bii tharangalumayi thaarathamyappeduthumbol eiii1-sidablue7-bii8 yadhaarthathil pratheekshichathilum kuravaanennu dr3-dii. kyu2/diiaarr4-dii. kyu8 phinodypinekkurichulla sameepakaala padanatthil kandethi, ithu bii8 num dr3 num idayil apakadasaadhyathayumaayi bandhapetta jeenukal sthithicheyyunnuvennu soochippikkunnu. ennirunnaalum mattidangalil nadatthiya oru padanatthil sidablue7-bii8 allah, type 1 pramehathinulla apakadasaadhyathaye oru * 01:01 maattumenn kaanikkunnu. type 1 pramehatthinte udaaharanam siffer apakadasaadhyathayilekku maathram linkej vishakalanam upayogikkunnathile antharleenamaaya budhimuttu kaanikkunnu.
eiii1, allergy rogam, samvedanakshamatha.
echeleyekkurichulla padanatthinte thudakkathil allergy rogathil echla 1, bii 8 enniva thammil oru bandham kandethi, iva vipuleekritha hla 1-bii 8 mekhalayumaayi bandhippikkunnuvennu kandethiyittundu. 
vichithramennu parayatte, methotreksett-induced liver sirosisumaayi eiii1 bandhappettathayi kandethi. athesamayam kalkari thozhilaallikalude pneumoconiosis, kushtam thudangiya mattu rogangalumaayi eiii1 negatteevu aayi bandhappettirikkunnave kandethi.
eiii1 umm pakarchavyaadhiyum.
aadyakaala padanangalil, eiii1 chila pakarchavyaadhikalumaayi bandhappettatho avayil ninnu samrakshikkappettatho aanennu kandethi. eiii1-maayi bandhappettathayi kaanapedunna chila rogangal yadhaarthathil vipuleekritha eiii1-bii8 haplotype, vairal induced heppattaitis, echuaivi ennivayude thwarithappeduthiya purogathi ennivayumaayi bandhappettirikkunnu.
bii8 ulla eiii1 measles anubaadhaykkulla saadhyatha vardhippichathaayi kaanichu, ennirunnaalum, praadhaanyam sthiramaayirunnilla. ettavum puthiya oru prabandham measles vaaksinodulla sharashari prathikaranathekkaal kurravulla oru * <aii. dii. 1>-nte bandham kaanichu. rubella, maathru kaimaattatthinte falamaayi rogabadhitharaaya aalukalil eiii1-bii8 kooduthalaayi kaanapedunnu. 
sarkkomaral herpesumaayi eiii1 bandhapettirikkunnathum kandethi. eiii1, jaladosham enniva thammilulla bandhavum vivarikkapettu. pinneedu, herpus simplexinte bandhavum kaanichu.
lymphomyil eiii1.
hodjkinte lymphoma echu. ell. eiii-eiii1ll, pakshe doow. aarr. 3 kooduthalaayi kandethiyilla. entaroppathi-anubandha tii-sell lymphomayumaayi ariyappedunna oru bandhamullah eiii1-bii8-dii. aarr. 3-dii. kyu. 2 haplotypinu ekadesham 70 sathamaanam rogikalum dii. kyu. 2-nuu homocygottukalaaya dii. aarr. 3-dii. kyu. 2-nte oru pakarppenkilum undu.
alleals.
oru * <aii. dii. 1> nalkunna rogasadhyathayil bhooribhaagavum eiii1 serotype apakadasaadhyathakalo eiii1-bii8 serotype apakadasaadhyathayo prathinidheekarikkunnu (europil eiii1-bii8 mikkavarum ellaayppozhum eiii * <aii. dii. 1>, bii * <aii. dii. 2> enniva chernnathaanu). mattu alleelukalaaya a * 01:02, a * 01:03 enniva prathyeka apakadasadhyathakal nalkiyekkaam. udaaharanathinu, sickle sell anaemiya ulla kuttikalil pathivayi kaanapedunna oru tharam strocumaayi oru * 01:02 bandhappettathayi kandethi.
american aikyanaadukalile somali samoohangalil eiii1 vahikkunnavaril moonnil rund perkkum eiii * 01:03 isophome undennu oru reportund. 

