
lactotripeptideukal

swaabhaavikamaayi undaakunna rund paal peptaidukalaanu lactotripeptaidukal isolucin-prolin-prolin (aii. pii. pii), valin-prolin-prolin (vii. pii. pii). paalulppannangalil kaanapedunna paal proteinaaya keysinil ninnaan eee lactotripeptideukal uruthirinjathu. mikka saadhaarana paal uthppannangalilum lactotripeptideukal adangiyittundengilum avaa yadhaartha paal proteinukalkkullil nishkriyamaanu. paal protein ensaimaattikkaayi cheria kashanangalayi vibhajikkunna oru prakriyaya ensaimatik predisioniloode dayari pepttaidukal phalapradamaayi puratthuvidaam. aarogyakaramaya bhakshanathinteyum jeevithashailiyudeyum bhaagamaayi aarogyakaramaya rakthasammardhathinte alavu prolsaahippikkaan eee lactotripeptideukal sahaayikkunnuvenn chila klinikkal padanangal soochippikkunnu. ennirunnaalum, mattu klinikkal pareekshanangal eee samyukthangalil ninnu oru phalavum kanditilla.
nirddishta samvidaanam.
angiotensin-converting ensaiminte (easu) pravartthanatthe thadayaan dayari pepttaidukal nirddeshikkappedunnu. shareerathile rakthasammardham niyantrikkaan sahayikkunna oru swaabhaavika samvidaanamaaya renin-angiotensin sisttathinte bhagamaanu easu. chila vyakthikalil, palappozhum sammarddam, anarogyakaramaaya bhakshanakramam, koodaathe/allengil anarogyakaramaaya jeevitashaili enniva kaaranam renin-angiotensin sisttam amithamaayi sajeevamakum. atharam saahacharyangalil, easu amithamaayi sajeevamaakukayum kooduthal angiotensin I-neey angiotensin II-aakki maattukayum cheiyunnu. angiotensin II rakthakkuzhalukalk sankochamundaakkukayum rakthasammardham vardhippikkukayum cheiyunnu, ithu rakthaathimardhathilekku nayikkaan saadhyathayund. ennaal, easu pravartthanam thadayumbol, angiotensin II-nte roopeekaranam kurayunnu. ithu rakthakkuzhalukale visramikkaanum aarogyakaramaya avasthayilekku veendum vikasippikkaanum sahayikkunnu, athinaal rakthasammardham kuraykkunnu.
klinikkal pareekshanangal.
rakthasammardhathil lactotripeptaidukale swaadheenam vilayiruthukayenna lakshyathode niravadhi manushya pareekshanangal nadatthi. chila pareekshanangal mithamayathum mithamayathumaaya rakthaathimardhamulla aalukalil lactotripeptaidukale rakthasammardham kuraykkunna prabhavam kaanikkunnu, ennirunnaalum mattullava eee pepttaidukalil ninnu oru phalavum kanunnilla. saahithyathinte sameepakaala chittayaya avalokanathil manushyaril sthireekaricha easu-inhibittar efakttukalonnum kandethiyitla, athupole thanne lactotripeptideukal vijayakaramaya oru edapedalaayi nirnnayaka thelivukalonnumilla; mettaa-vishakalanam reethishaasthrathile vaividhyavum padanangal thammilulla vyathyaasathin kaaranamaayi muun mettaa-analysis vazhi sameepakaala valia padanangal ulppeduthaathathum udharichu.

