
henry laber

oru franch sarjan, neurobiologist, ezhuthukaaran, thathwachinthakan ennee nilakalil prashasthanaayirunnu henry laberit (21 november 1914-18 meyy 1995). 1952-ll, chlorpromacin enna marunninte vikasanathil laberit nirnaayaka punk vahikkukayum thante kandethalukal prasidheekarikkukayum oru rogiyil ithu pareekshikkaan moonnu cycatristukale bodhyappeduthukayum cheythu, ithu valia vijayathin kaaranamaayi. laberit addehathinte pravarthanatthinu amgeekarikkappettuvenkum anasthettikkinaayi thirayunna oru sarjan enna nilayil, swantham kandethalukalum malsaraadhishtitha avakaashavaadangalum nadatthiya cycatristukalumaayi addehathinu abhipraayavyathyaasamundaayi.
laberit niravadhi pusthakangal ezhuthukayum avide addeham thante dhaarmika laborattari gaveshanathe moshamaayi chithreekarikkukayum, samvidaanachinthayiloode, mattu niravadhi vishayangalil ninnulla arivu upayogichu, interdisiplinaarittiyum traansdisiplinaarittum sakthamaaya vakthavaayi athine vivaham kazhikkukayum cheythu. addehathinte rachanakalkk araajakathva chinthayil aazhathilulla verukalundennum kandethaam. shaasthrathinte aavashyakathakalum sarvakalashala jeevithathile parimithikalum addehathe vyakthiparamayi aswasthanaakkiyilla. academica mekhalayil ninnu swaathanthryam nilanirtthiya addeham shaasthram athinte anuyaayikalil ninnu aavashyappedunna chittayaya phalangal nalkaan orikkalum sramichittilla.
kudumbavum aadyakaala varshangalum.
1914ll franch indochainayile hanoyiyil henry laberit janichu. addehathinte pithaav oru vaidyan colonial offeesarumaayirunnu, addeham 1920ll tetanus baadhichu marichu. 12-aamm vayassil kshayarogam baadhicha addeham paareesil ninnu oru bachaloriyatt nedi. rund varsham addeham indochainayil oru ashupatri kappalil chelavazhichu. bordo naavika aarogya sevanathil pareekshayil vijayikkukayum naavika vaidyanaayi maarukayum cheythu. addehathe biserte sidi abdullahilekku ayachu. amgeekaarathinulla oopshanukal mikachathaayirikkumennu thonniya addeham oru sarjan aayi maari. randaam lokamahaayudhasamayathu addeham torpido boat syrocoyil nilayurappikkukayum avide addeham dankarkkinte ozhippikkalinu saakshyam vahikkukayum thudarnnu jarmmankaar mungukayum cheythu. oru engleesh sloop addehathe rakshichu. franch sainika kurish addehathinu vishishtathayode labhichu. pinneedu addehathe dackeril paarppichu. 1949 aayappozhekkum addeham paareesile wall-dii-grass ashupathriyil niyamikkapettu.
chlorpromacin.
chlorpromassinte saadhyathayulla maanasika upayogangal aadyamaayi thiricharinjathu laberitaanu.
1930kall muthal anastheshya shaasthram puthiyathaayirunnu. shasthrakriyakalkk chilappol sasthrakriyakal utharavaadikalaayirunnu, oru franch naavika sarjan enna nilayil, shasthrakriyayude falamaayo sheshamo rogikal marikkunnath prasavavedanayil kandirunnu. anastheshyashaasthrathil addeham oru gaveshakanaayi. anastheshyayekkurichulla laberitinte ashayangalil pottenshated anastheshya, basel metabolism kuraykkuka, shareera thaapanila kuraykkuka (krithrima hibernation ennu vilikkappedunnu) enniva ulppedunnu. procain, synthetic antihistaamains, diparcol (daithasin), tetrithylamonium bromide, vitaamin bii 1 ennivayude upayogathe addeham vaadichu. morphin upayogikkaan addeham eshtappettilla. bysertayile varshangalil shasthrakriyaykk munbu rogikale kooduthal shaantharaakkunnathinum anastheshyaykku sambhavana cheiyunnathinum aantihistaamain promethasin upayogikkunnathil addehathinu thaalpparyamundaayi, eee nireekshanangal chlorpromasinodulla addehathinte pilkkala thaalpparyatthinte mungamiyaayirunnu.
piyar huguenardinoppam, shasthrakriyaykkidayilum sheshavum rogikalkku anubhavappedunna njettalum sammarddavum kuraykkunnathinu nalkaan kazhiyunna marunnukalude samyojanamaaya laittik kokteyil laberit kandupidichu. akkaalat deparcol, dolosal ennee vyaapaaranaamangalil promethasinum pethidine samyojippichukondu hugunard vijayikkukayum thante kandethalinekkurichu laberitinode parayukayum cheythu. rogikale krithrima hibernation avasthayilekku athikkunnathu sammarda prathikaranangalude chila vashangal thadayumennu laberit karuthi. eee marunnukal shareerathe thanuppinodulla prathikaranangal nirthaan prerippichu.
kendra naadeevyavasthayude sthiratha mechappeduthunna antihistaamains srishtikkaan laberit roonn-poulenkkinodu (sanofiyaayi marria oru farmaceutical kambani) nirddeshichu. avide, rasathanthranjanaaya pooll charpentier nilavilulla marunnu diphenhydramine (benadryl, dramamine, sominex) mechappeduthaan sramikkunna oru samghathe nayichu. athinaal charpentier oru chlorin aattam cherthu phenotheasinukalude oru puthiya parambara srishtichu.
simoon corvoisier laborattari elikalil eee parambara pareekshikkukayum aarpi 4560 (chlorinated promassin, pinneedu chlorpromacin ennariyappettu) epinephrinte phalangal vipareethamaakkukayum udaaseenathayo nissangathayo undaakkukayum cheiyumennu kandethukayum cheythu. chharddi, vedana, ookkaanam, virayal ennivaykkulla marunnu 1952 ll europil roonn-poulenku largactil ennu vipananam cheythu. laberit eee marunnin "valia pravartthanam" ennathinte mishrita padamaaya peru nalkiyathaayi parayappedunnu.
addeham, hugunard, aarr enna oru associate. alluvom "eiii nyoo vegetative stabilizer 4560 aarpi" prasidheekarichu."1952 februvariyil" "laa pras medical" "enna pusthakatthil maiks bennatt parayunnathanusarichu," "thaalpparyamillayma" undakkunnathinulla marunninte prabhavam eee savisheshatha athine maanasika upayogamaakki mattaanulla saadhyathayodoppam paraamarshikkappedunnu "."
1951 desemberil roonn-polenkil athinte samanvayathethudarnnu, parikketta sainikaril njettal kuraykkunnathinaayi pareekshikkaan 4560 aarpi sample laber abhyarthichu. eee marunnu upayogichu chikilsikkunna aalukal avarude chuttupaadukalodulla thaalparyam kurachuvennu addeham nireekshichathinaal, haamon, parair, vellues ennivar nadatthiya anticycoticsinte aadya parisodhana nirddeshikkaan addehathe prerippichu. unmaadamulla 24 kaaranaya rogiye wall-dii-grassil ninnu mochippikkukayum chlorpromassine baarbitturettukalum upayogichu 20 divasathe chikilsaykku sesham "saadhaarana jeevitam punaraarambhikkaan" thayyarakukayum cheythu.
ithinu gurutharamaaya paarshwafalangalundengilum, chlorpromacin "gurutharamaaya maanasikarogatthinte mukham maattaan sahayichu", koodaathe niravadhi rogikale maanasika abhayakendrangalkku purathu jeevikkaan anuvadichu; amerikkayil, maanasika sthaapanangalile inpatiant janasamkhya 1955 ll 559,000 ll ninnu pathuvarshatthinushesham 45,000 aayi kuranju."
lasker award.
1957ll chlorpromassinte pothuvaaya upayogathinu piyari denicker, hains lehmann ennivar nalkia sambhaavanakalkk laberit lasker-debeki klinikkal medical research award pankittu. eee kandethalinu arcum nobal sammanam labhichilla, svayam vijayikkaan aagrahicha seyante-aan ashupatri kendratthinte jeane delay, nobal kammittiyil irunnu, pakshe athu laberitinu nalkunnathine ethirthu. jeevithakalam muzhuvan seyante-aan ashupatri jeevanakkarumaayi laberit thante abhiprayavyathyaasangal prakadippichu.
1957ll lasker foundeshanum nathan ezz. neey amgeekarichu. cline roobert echu. nose, iruvarum maanasikarogathinulla chikilsayaayi resurpine vikasippichu, athupole resurpine upayogichu hypertension chikilsikkunnathinulla rasttam jaal vakkeel, bandhamillaattha richard iii. vairasukalekkurichulla nammude daaranaykku thudakkamidunnathinu shope cheyyuka.
currier.
paareesile bosicolt hospitalile laborattoyar dii utonology director laberit maari. addehathinte thalpparyangalil psychotropic marunnukalum oormmayum ulppedunnu.
alexander saitsev 1874-ll jii. echu. bii. samshleshithamaakki, 1960-ll laberit marunnu samshleshithamaakki. neuro traansmittar gaabayude munnodiyaayi addeham jii. echu. bii. yeei gaveshanam nadathukayaayirunnu. 1964 septambaril laberit "internaashanal jenal oof neuroformacologyil" "soodiyam 4-hydroxybuterate" prasidheekarichu.
puraskaarangalum saamskaarika paraamarshangalum.
laberitinu croix dii gyoore savisheshathayode labhichu. 1953ll lejian oof oonarinte shevaliyarayi thiranjedukkappetta addehathinu roonn-polenkine prathinidheekarichu amerikkayilekku yaatra cheytha sesham 1957ll pankitta lasker-debeki klinikkal medical research award labhichu.
1980 ll addeham svayam avatharippikkunna alan resnice chithram "moonn oongil dii 'americ" yude sathayaanu laberitinte ashayangal.
dally vaayichenkilum manassilaakaatha thante oru pusthakathekkurichu salvador daaliyumaayi laberit abhimukham nadatthi.
maranavum paarambaryavum.
thante amgeekaarathil vanjichathaayi laberitinu thonniyathaayum thaan oru kayperiya manushyanaayaan marichathennum healey ezhuthi. eee record nereyakkaanulla chila sramangal healey shradhichu 1980 ll jeane thooliyar ezhuthiya kaalathamasavum denicker laberitum ennu visheshippikkunna oru pusthakam, 1960 ll aan caldwell ezhuthiya laberitinoppam ninna oru pusthakam, 1974 ll judith swaasiyude "chlorpromacin inn saikyatriyil" enna pusthakam enniva irupakshathinum credit nalki. 1992 ll roonn-poolink nadatthiya anusmaranathil anastheshyaykku laberit credit nalkiyengilum saikyatriyil chlorpromacin prayogichathinu denicker, kaalathamasam credit nalki. 1994ll wall-dii-grass sthaapithamaayathinte 200-aamm vaarshikathil, 1952ll laberit, haarmon, parair, vellues ennivar chlorpromacin kandethiyathinte smaranaykkaayi oru phalakam avide sthaapichu.
fraansile sankeernnatha sidhaanthathinteyum svayam samghadanayudeyum thudakkakkaaril oralum group dess dixumaayulla koodikkaazhchakalil "sankeernamaaya chintha" yude thudakkaaranumaayirunnu laberit. "sankeernamaaya chintha" pinneedu edger morin janapriyamakki.

