
ashchoff body

vaidyashaasthrathil, roomattik panii ulla vyakthikalude hridayathil kaanapedunna nodyoolukalaanu ashcoff bodikal. avaa hridaya peshikalile veekkam moolamundaakunnavayumaanu, koodaathe roomattik hrudrogathinte savisheshathayumaan. ludwig ashchof pooll rudolph geepell swathanthramaayi kandethiya eee noduleukal eee kaaranathaal avaye idaykkide ashchoff-geepal bodikal ennu vilikkunnu.
roopam.
microscopic aayi, hridayathinte connective tissuevinte veekkam allengil phokkal intersteeshyal veekkam enniva ulppedunna pradesangalaanu ashcoff bodikal. fibrinoid maattam, lymphocytic nuzhanjukayattam, idaykkide plasma koshangal, necrotic kendrangalkku chuttumulla asaadhaarana macrophageukal enniva ulkkollunna granulomatus gadanakalaanu poornnamaayum vikasippicha ascoff bodikal. eee macrophageukalil chilath samyojichu multinucleated bheeman koshangal roopappettekkaam. mattullava kromaattin roopabhaavam kaaranam ariyappedunna aanitsko koshangalo kaattarpillar koshangalo aayi mariyekkaam.
mikkappozhum myocardium enna pala sthalangalilum kaanapedunna fibrinoid nekrosisinte pathognamic phosikalaanu avaa. thudakkathil avaykku chuttum lymphocyteukal, macrophageukal, kurachu plasma koshangal ennivayundengilum avaykku pakaram pathukke oru naarukalulla paadukal varunnu. hridayathinte moonnu paalikalilum ascoff bodikal kaanapedunnu, perikaardiyatthil ettavum kuranja saadhyatha.
hridayasambandhamaaya murivukalude saannidhyam.
roomattik paninte hridaya prakadanangal hridayathinte moonnu paalikalilum intersteeshyal tissuevinte phokkal inflammatory edapedalinte roopathilaanu, pancarditis enna rogalakshanaparamaaya maattam. roomattik hrudrogathinte kaaryatthil paankaardittisinte pathognomonic savisheshatha ascoff nodyoolukaludeyo ascoff bodikaludeyo saannidyamaanu.
vishadamaaya vivaranam.
tii lymphocytukalude phoosikal, idaykkide plasma koshangal, roomattik panikk kaaranamakunna activated macrophageukal (anitskov koshangal) pathogonomonic ennivayaanu ascoff noduleukal. eee macrophageukalkku dhaaraalam cytoplasavum central raundu nucleus undu, athil kromaattin oru central, nerttha, alakalulla ribanaayi ghaneebhavikkunnu, athinaalaan avaye chilappol "kaattarpillar cellukal" ennu vilikkunnathu. 
myocardiathileyum endocurdiathileyum cheria rakthakkuzhalukalude sameepath idaykkide perikaardiyatthilum iorta sameepabhaagathe adventiciayilum iva prathyekichum kaanapedunnu. ascoff noduleukalkku samanamaaya murivukal extra-cardiac tissuekalilum kaanapedaam.
nodyoolukalude parinamam.
ascoff nodyoolukalude parinaamatthil saadhaaranayaayi vikasanathinte 3 gattangal ulppedunnu, avayellaam parisodhanayude ore samayat hridayathil undakam.
ghattam 1. aadyakaala exudative/degenerative ghattam-roomattik paniyil hridayathinu parikkinte aadyakaala adayaalam rogathinte naalam aazhchayil prakadamaanu. thudakkathil connective tissuevinte edema nilathunilkkunna padaarthatthil assid mucopolisacredine vardhanavum undaakunnu. ithu kolajan naarukale verthirikkunnathilekku nayikkunnu, ithu bhoomiyile padaartham shekharikkunnathiloode kolajan naarukal vighadikkukayum vighadikkukayum cheiyunnu, koodaathe baadhicha focus fibrinte roopavum karayum savisheshathakal edukkunnu.
ghattam 2. intermediat proliferative/granulomatus ghattam. ithu ascoff bodikalude eee ghattathilaanu, ithu roomattik panikk rogalakshanamaanu. rogathinte 4 muthal 13 aazhchakalkkullil eee ghattam prakadamaanu. fibrinoid maattatthinte aadyaghattathinu pakaram lymphosite tii cellukal, plasma cellukal, neutrophillukal, kshathatthinte arikilulla swabhaavasavisheshathayulla cardiac histiyosaittukal/aanitsko koshangal ennivayude nuzhanjukayattam nadathunnu.
hridayathil cheria thothil cardiac histiyosaittukal/aanitsko undengilum ascoff nodyoolukalil avayude ennam vardhikkunnu. athinaal avaa roomattik hrudrogathinte savisheshathayalla.
ghattam 3. vaikia fibrosis ghattam. asukham vannu 12 muthal 16 aazhchakalkkullil ascoff nodyoolukalude fibrosis sambhavikkunna rogashaanthiyude ghattamaanith. 200 micrometer x 600 micrometer veethiyum neelavum ulla aakruthiyil nodule oval allengil fusifom aayi maarunnu. maasangalum varshangalum kadannupokumbol ascoff noduleukal sellular kurayukayum kolajan tissue vardhikkukayum cheiyunnu. oduvil ithinu pakaram perivascular aayi cheria sellular ulla oru cheria fibrocologenous vadundu.
charithram.
1904 ll jarmman paatholajist ludwig ashchof oru varshathinusesham pooll rudolph geepell chernnaanu aashchofinte mrithadehangal swathanthramaayi kandethiyathu.

