insulin glargin

type I, type II pramehangal kaikaaryam cheiyunnathinu upayogikkunna medical insulinte deerghakaalamaayi pravartthikkunna parishkaricha roopamaanu laanttas enna brand naamatthil vilkkunna insulin glargin. ithu charmmathinu thaazheyaan kuthivaykkunnathu. saadhaaranayaayi upayogam kazhinju oru manikkoorin sesham efakttukal aarambikkunnu.
rakthathile panchasaarayude alavu kurayuka, kuthivayppu nadatthiya sthalathe prasnangal, chorichil, sareerabhaaram vardhikkuka enniva saadhaarana paarshwafalangalil ulppedunnu. mattu gurutharamaaya paarshwafalangalil rakthathile pottasyam kuravaanu. garbhaavasthayil insulin glarginekkaal enn. eph. echu insulinaanu saadhaaranayaayi eshtappedunnathu. kuthivayppinu sesham, microchristalukal pathukke ekadesham 24 manikkoor insulin purathuvidunnu. eee insulin sareerakoshangal rakthathil ninnu glucose agiranam cheyyaan kaaranamaakukayum karalil glucose uthppaadanam kuraykkukayum cheiyunnu.
2000-ll amerikkayil insulin glargin vaidyashaasthraparamaaya upayogathinaayi amgeekarikkappettu. ithu lokaarogya samghadanayude avashya marunnukalude pattikayil ulppedunnu. 2020ll 17 dashalakshathiladhikam kurippadikalulla amerikkayil ettavum saadhaaranayaayi nirddeshikkappedunna 32-aamathe marunnaanith. 2021 joolaiyil, us phudu aandu drugg administration (fda) prameha chikilsaykkaayi sengli (insulin glargin-ifgn) enna parasparam maattaavunna biosemiller insulin uthppannathin amgeekaaram nalki.
medical upayogangal.
insulin glargin ulppedunna deerghakaala insulin klaas, neutral protamine hagedon (enn. eph. echu) insulinekkaal mikachathaayi kaanapedunnilla, pakshe avaykku kooduthal chelavaakum, ithu 2010 leeii kanakkanusarichu type 2 pramehatthinte chikilsaykku chelavu kuranjathalla. deerghakaala falangalumaayi bandhappett enthengilum vyathyaasangal nirnnayikkaan mathiyaya daatta illaathathinaal hypoglycemy vyathyaasamundo ennu muun avalokanathil vyakthamalla, ennirunnaalum ettavum puthiya cochrain chittayaya avalokanathil insulin glargin enn. eph. echu insulin, insulin dittemir allengil insulin digluduc ennivayumaayi thaarathamyam cheyyumbol 6 maasamo athil kooduthalo praayamulla muthirnnavarilo kuttikaliloo type 1 prameham kaikaaryam cheiyunnathil klinikkal praadhaanyamulla vyathyasam kandethiyilla. ithu saadhaaranayaayi yunaittad kingdatthil shupaarsha cheiyunna deerghakaala pravartthana insulin allah.
type 1 pramehamulla muthirnnavarilum kuttikalilum type 2 pramehamulla muthirnnavarilum glycemic niyanthranam mechappeduthunnathinna sengli soochippikkunnu. sengli athinte reference ulppannamaaya laantas (insulin glargin), deerghakaalamaayi pravartthikkunna insulin analogumaayi biosemiller (pakaram vaykkaam) parasparam maattaavunnathumaan.
mattu insulinukalumaayi kalarthuka.
kooduthal samayam pravartthikkunna mattu insulinukalil ninnu vyathyasthamayi, ore sirinchile mattu insulin allengil layaniyumaayi glargin layippikkukayo kalarthukayo cheyyaruthu. ennirunnaalum, eee niyanthranam chodyam cheyyappettittund.
prathikoola phalangal.
rakthathile panchasaarayude alavu kurayuka, kuthivayppu nadatthiya sthalathe prasnangal, chorichil, sareerabhaaram vardhikkuka enniva saadhaarana paarshwafalangalil ulppedunnu. gurutharamaaya paarshwafalangalil rakthathile pottasyam kurayunnu.
2012 leeii kanakkanusarichu, insulin glargin, cancer enniva thammil oru bandhavum thaalkkaalika thelivukal kanikkunnilla. munkaala padanangal aashanka uyarthiyirunnu.
insulin glargine enn. eph. echu insulin, insulin dittemir allengil insulin digladec ennivayumaayi thaarathamyam cheyyumbol, 6 maasamo athil kooduthalo praayamulla muthirnnavarilo kuttikaliloo type I prameham niyanthrikkunnathil kaaryamaaya prathikoola phalangalonnum kandethiyilla.
farmacology.
pravartthana samvidaanam.
eiii-cheyinte 21-aamm sthaanathu aaspaaraajinte sthaanathu glycine upayogikkukayum bii-cheyinte carboxy-terminal ekstenshan 2 arjinin avashishtangalakkukayum cheythukondu insulin glargin manushya insulinilninnu vyathyasthamaan. arjinin amino aasidukal aiso electric pooyintine 5.4-ll ninnu 6.7-lake maattunnu, ithu thanmatra acidic piechil kooduthal layikkunnathum physiological piechil kuravu layikkunnathum akkunnu. isoelectric shift oru vyakthamaaya laayaniyude subcutaneous kuthivayppinum anuvadikkunnu. glycine pakarakkaaran acidic piechil assid sensitiivu asparajin demidation thadayunnu. neutral subcutaneous sthalathu, uyarnna oordar aggregettukal roopappedunnu, ithu kuthivayppu nadatthiya sthalathu ninnu insulin pathukke, ettavum uyarnna alavil layikkunnathinum agiranam cheiyunnathinum kaaranamaakunnu. ithinu kuranjathu 24 manikorengilum peak less level nedaan kazhiyum.
shareerathil sweekaaryathayum punar vibhajanavum.
insulin glargin oru acidic piechu 4 ll roopappeduthunnu, avide athu poornnamaayum vellathil layikkunnu. acidic solyoottinte subcutaneous kuthivayppinu sesham (ithu aswasthathayum kudukalum undaakkum), oru physiological piechu (ekadesham 7.4) nedumbol piechinte vardhanavu insulin laayaniyil ninnu puratthuvaraan kaaranamaakunnu, athinte falamaayi uyarnna oordar aggregettukalude roopeekaranam insulin hexamerukal. uyarnna oordar aggregation hexamerukalude insulin monomarukalilekkulla vighadanathe mandagathiyilaakkunnu, ithu insulinte pravartthanaparavum shaareerikamaayi sajeevavumaaya yoonittaan. eee kramanugathamaaya prakriya cheria alavil insulin glargin shareerathilekku thudarchayaayi purathuvidunnuvennu urappaakkunnu, ithu eathaandu peakless profile nalkunnu.
charithram.
2000 juun 9 nuu, europian kammeeshan sanofi-avantis jarmmani limittad laantas vikshepikkunnathinu audyogikamaayi amgeekaaram nalki. europian unionile muzhuvan. 2005 juun juun praveshanam neettiyirunnu.
2015ll eph. dii. eiii. yude amgeekaarathinu sesham moonniratti kendreekrithamaaya oru formulation, brand naamamaya tojio avatharippichu.
samoohavum samskaaravum.
niyamaparamaaya padavi.
biosemilaarukal.
2014 septambaril europian yooniyanil medical upayogathinaayi abasaglerinu amgeekaaram labhichu.
2017 januvariyil europian yooniyanil lasduna vaidyashaasthraparamaaya upayogathinu amgeekaaram nalki.
2018 maarchil, insulin glargin (sengli) europian yooniyanil medical upayogathinaayi amgeekarichu.
2021 joolaiyil, insulin glargin-ifgn (sengli) yunaittad stetsil vaidyashaasthraparamaaya upayogathinaayi laantasinte aadyathe parasparam maattaavunna biosemilleraayi amgeekarichu. mylan farmaceuticals incorperatinu eph. dii. eiii. sengliyude anumathi nalki.
pettant kaalavadhi avasaanikkunnu.
insulin glargin pettant samrakshanam 2015-lum yuu. esilum mikka raajyangalilum kaalaharanapettu.ezz.eiii. 2015ll busgler (amerikkayil fooloo-oonn aayi), abasaglar (europian unionile biosemiller aayi) ennee brand namangalil ethiraaliyaaya elii lillil ninnulla insulin glargin mikka raajyangalilum labhyamaayi.

