
serotonilation

proteinukalil deerghakaala samayathekku nilanilkkunna kovalant bondukal srishtikkunnathiloode serotonin intra sellular prakriyakal sajeevamaakkunna oru risapttar swatantra signalling samvidaanamaanu serotonilation. glutamine avashishtangalil serotonin gadippichukondu proteinukalude parishkkaranatthiloodeyaanu ithu sambhavikkunnath. transglutaminase ensaiminiloodeyum glutamile-amide bondukalude srishtiyiloodeyum ithu sambhavikkunnu. 5-echu. tii resepterukal sajeevamaakkumbol serotoninu undaakunna hrasvamaaya edapedalukal pole plasma membranukalilalla serotonin koshatthilekku kondupookunnathine thudarnnaanu eee prakriya sambhavikkunnath. 
pravartthanangal.
platelettukalil (thrombositeukal ennum ariyappedunnu) ninnulla alfa-graanulukalude exocytosisine serotonin badhikkunna prakriyayaan serotonylation. raab 4, rowa thudangiya cheria jidipesukalude serotonilation ithil ulppedunnu. hemostaasisilum thrombosisilum 5-echu. tii. yude prathyeka hormon pankinekkurichu kooduthal manassilaakkunnath hanikaramaaya raktasrava, hridayasambandhamaaya vaikalyangal thadayunnathinum chikilsikkunnathinum pradhaanamaan" ennu nirddeshikkappettittund."shwaasakosha rakthaathimardhathil nirnaayaka punk vahikkunnathayi serotonilation aduthide thiricharinjittundu.
paankriyaasile beetaa koshangalil ninnu insulin purathuvidunnathu serotonin niyanthrikkunna prakriyayilum rakthathile glucosinte alavu niyanthrikkunnathilum cheria jidipesukaliloodeyulla serotonilation ulppedunnu. transglutaminasile vaikalyangal glucose asahishnuthayilekku nayikkunnath enthukondaanennu vishadeekarikkaan eee punk sahayikkunnu. cheria jidipesukal ulppedunnundengilum, protein-boundu serotoninte valia alavu nilanilkkunnath ippozhum thirichariyappedaatha mattu serotonylation edapedalukalude saannidhyathe soochippikkunnu. 
cheria jidipesukal ozhikeyulla proteinukalude serotonilation iorta ulppedeyulla rakthakkuzhalukalile vascular minusamarnna peshi "toonn" niyanthrikkunnathin adivarayidunnu. alfa-aaktin, beetaa-aaktin, gaama-aaktin, myosin hevi cheyin, philamin eiii thudangiya cytoskelittanukalum kontraakttilittiyum avibhaajya gadakamaaya proteinukaludeyum serotonilation parishkkarikkunnathiloode ithu sambhavikkam.
charithram.
chilarude abhipraayathil serotonin "athinte uravidathinum (sero-) minusamarnna peshi toonn (tonin) parishkkarikkanulla kazhivinum" perittathaanu, ithu serotonilatione aashrayichirikkaam (chila vivaadangal nilanilkkunnu). 
2003ll digo jeey aanu "serotonilation" enna padam srishtichathu. walther maiks plank instittyoott phoor molecular janithakashaasthrathile sahapravarthakarum jenal sellile oru prabandhatthil.

