
rogaprathirodha sheshi

rogaprathirodha samvidaanathe roopappeduthunna jeenukaludeyum proteinukaludeyum koottamaanu immunom, mattu kosha tharangalil vyaapakavum rogaprathirodha prathikaranatthil thanne ulppedaathathumaayava ozhike. rogaprathirodha samvidaanavumaayi edapedunna proteomil ninnu uruthirinja pepttaidukalude koottamaayi ithine kooduthal nirvachikkunnu. manushyarudeyum elikaludeyum manushyarallaatha praimettukaludeyum gadakangaludeyum rogaprathirodhasheshi savisheshamaakkunnathinum krameekarikkunnathinumalla niravadhi sramangal nadakkunnundu. saadhaaranayaayi, rogaprathirodhavumaayi bandhapetta ensaimukaludeyum paathakaludeyum saannidhyavum pravartthanavum nirnnayikkaan immunofluorescence microscopy upayogichu rogaprathirodhakoshangale padikkunnu.
prathirodhasheshi padikkunnathinulla praayogika prayogangalil waxinukal, chikitsa proteinukal, mattu rogangalude kooduthal chikitsa enniva ulppedunnu. rogaprathirodhasheshiyekkur patanam rogaprathirodhashaasthra mekhalaykku keezhilaanu.
padavyuthpathishaasthram.
immyoon", "chromosome" ennee vaakkukalude samyojanamaanu immunom enna vaakk."kooduthal charchakalkku oomiks kaanuka.
swabhaavam kaanikkanulla sramangal.
manushyante rogaprathirodhakoshathinte krithyamaaya valippam nilavil anjjaathamaanu, ithu pathittaandukalaayi patana vishayamaan. ennirunnaalum, ithu encode cheiyunna vivarangalude alavu, bhaagikamaayi, soomatik hypermutation junctional vaividhyavum kaaranam manushya genome valuppathe pala kramangalil kaviyunnuvennu parayappedunnu. manushyarudeyum mattu jeevajaalangaludeyum rogaprathirodhasheshi savisheshamaakkunnathinulla niravadhi sramangal nadakkunnundu.
2016ll aarambhicha oru pradhana sramam, human waxinukal padhathi, vaandarbilt yooniversitti medical sentar, ilyumina ink enniva thammilulla sahakarana padhathiyaanu. human immunom prograam enna peril ariyappedunna eee padhathi manushya janasamkhyayil ninnu bii, tii rogaprathirodha kosha resepterukalude poornna shekharam manassilakkuka ennathaanu lakshyam. eee lakshyam nedunnathinu aayirakkanakkin vyakthikale padikkendathundu, avar vividha praayangal, lingabhedangal, vamsheeyathakal, bhoomishaasthraparamaaya uthbhavam enniva prathinidheekarikkendathund. koodaathe, rogangalullavareyum prathirodha kuthivayppu eduthavareyum padikkendathundu. prograaminte phalangal oru ooppan sourced daattabesaayi pankidum. bii, tii sell resepterukalkkullil puthiya advitheeya sequenceukal sambhavikkathe patthu varsham edukkumennu pratheekshikkunathuvare sequencing padhathi thudarum.
athupole, "jeane eksprashante samboornna microare vichedanam srishtikkukayum eliyude rogaprathirodha samvidaanathil athinte niyanthranam" srishtikkukayum cheyyuka ennathaanu immunological genome project enna oru gaveshana padhathi. mattoru vidhathil paranjaal, eliyude rogaprathirodhasheshiye nirvachikkanum savisheshatha nalkaanumaan padhathi sramikkunnathu. eee padhathi praadhamikamaayi oru praadhamika vibhavamayi pravartthikkaan uddeshichullathaanu, koodaathe gaveshakar samoohathil ninnulla nirddeshangal sajeevamaayi sweekarikkunnu. tii cellukal, bii cellukal, dendritik cellukal ennivayulppede padhathiyude vividha vashangalil pravartthikkunna 20 ladhikam gaveshana laabukal ulppedunna project teamil mouse immunominullile mattu pala tharatthilulla cellukalum ulppedunnu. 2008 muthal padhathi nadannuvarikayaanu.
manushyarallaatha rogaprathirodhashakthikalude, prathyekichu manushyarallaatha praimettukalude, manushyarumayulla janithaka saamyam kaaranam avayude savisheshathakal vivarikkanulla sramangalum nadakkunnundu.
patana reethikal.
rogaprathirodhavyavasthayekkum athinte savisheshathakalekurichum upayogapradamaaya arivu nedunnathinu, rogaprathirodha samvidaanathinte koshangalum gadakangalum vegathilum praayogikamaayum phenotype cheyyanam. rogaprathirodha samvidaanathinullil ariyappedunna noorukanakkinu kosha tharangalundu, rogaprathirodha prathibhasa saankethikavidyayile sameepakaala munnettangal upayogikkaathe avaa kandethaanum swabhaavasavisheshathakal nalkaanumulla saadhyatha valare akaleyaayirunnu, kaaranam oru vyakthiyude raktham valia alavil aavashyamaayirunnu. kaalaharanapetta eee reethiye loow dimensional immunophenotyping ennu vilikkunnu. ennirunnaalum, uyarnna alavilulla immunophenotyping ippol oru saadhyathayaanu. uyarnna alavilulla immunophenotypinging tharangale vishaalamaayi rund vibhagangalaayi tirikkaam lanthanide isodoppukalude upayogavum fluoroforukalude upayogavum. eee noothana saankethikavidyakal oru samayam 100 paaraamettarukal vare alakkaan anuvadikkunnu.
aaplikkeshanukal.
rogaprathirodhasheshi padikkunnathinu dooravyaapakamaaya prayogangal undakaan saadhyathayund. doow. rogaprathirodhakoshathil ninnu labhikkuna arivu tii sell eppithoppukalude kevala ennathil vyathyaasangal kandethunnathilekku nayikkumennum vyathyasthavum ennaal rogaprathirodhashaasthraparamaayi samanamaaya rogakaarikal thammilulla antigenic bandhangal velippeduthumennum aan dii groot vishwasikkunnu. svayam rogaprathirodha roga chikilsaykkum avayavamatta shasthrakriyaykkum saadhyathakalundenn avar parayunnu.
rogaprathirodha parisodhana oru tanmatra thalatthil pulmonary fibrosisinte lakshanangalum saadhyathayulla kaaranangalum nirnnayikkaan upayogapradamaanennu theliyikkappettittund.
carlos eph kaanichathupole prathirodha kuthivayppukalude vikasanam rogaprathirodha padanatthinte oru prayogamaanu. suurasum sahapravarthakarum. moonga kurangil ninnulla rogaprathirodha koshatthinte kosha uparithala resepterinte savisheshathayude falamaayi manushyaril eluppathil upayogikkaan kazhiyunna malaria vaaksinile gadakangal kandethaan avarkk kazhinju. eee kurangukal manushya malariaykku valare vidheyamaanennu theliyikkappettittund, athinaal avaa rogathinu oru nalla maathrkayaayi varthikkunnu. vairasinte niravadhi vakabhedangalil ninnu samrakshanam nalkunna oru influvensa vaxine vikasippikkaanum kazhiyum.
koodaathe, manushyarallaatha praimettukaludeyum mattu speesheesukaludeyum rogaprathirodhasheshi vishakalanam cheiyunnathu david eph kaanichirikkunnathupole speesheesukalude parinaamacharithrathe prathifalippikkum. plassa sahapravarthakarum. manushyarallaatha praimettukalil antibody theraappikal parishodhikkumbol avaa manushyarkk surakshithamaanennu urappakkaanum eee rogaprathirodha daatta sahayakamaakum. manushyan manushyarallaathathumaaya primate immunomukal thammilulla orthologue gadanayile cheria vyathyaasangalude pashchaathalatthil phalangal vyaakhyaanikkaan kazhiyunnathiloode ithu saadhyamaakum.
daattabesukal.
manushyante rogaprathirodhashakthiyudeyum mattu jeevajaalangalude rogaprathirodhashakthiyudeyum vividha vashangalumayi bandhapetta niravadhi daattabesukal undu.
immunom vijnjaana adithara (aii. keey. bii).
rogaprathirodha vijnjaana adithara (aii. keey. bii) enna eaka daattaabesilekk rogaprathirodha vivarangal kootticherkkaanulla sramam nadakkunnundu. eee sramathinu pinnile rund shaasthranjaraaya sabah oorttudeyum mouno vihinan moonnu vyathyastha daattabesukalil ninnulla daatta icbyilekku samyojippichittund. immunom, immtree, immunomabase ennee eee moonnu daattabesukalkkum immunomumaayi bandhapetta vyathyasthavum ennaal bandhappettathumaya vivarangalundu. hugo jeane naamakarana samiti, badal perukal, chromosomukalile jeenukalude sthaanangal enniva anusarichu audyogika jeane perukalilekkulla entrikal immunomil adangiyirikkunnu. orthologas jeenukalum phylogenetic treakalum ulppede rogaprathirodha samvidaanathinte tanmatra parinamavumaayi bandhapetta entrikal imtreeyilundu. avasaanamaayi, rogaprathirodha sheshiyumaayi bandhapetta oru multy-speeshees daattaabesaan immunomabase. mothatthil, 2009 leeii kanakkanusarichu, rogaprathirodhakoshathile jeenukalkkaayulla 893 entrikal ulppede 100,000-ladhikam dattaa enangalkkaayi aii. keey. bii. kku entrikal undu.
rogaprathirodha epittopp daattaabes (aii. iii. dii. bii).
rogam, allergy, svayam prathirodhasheshi, transplantation ennivayumaayi bandhappettathinal manushyarilum manushyarallaatha praimettukalilum mattu speesheesukalilum padicha antibody, tii sell epittoppukalekkurichu daattaykkulla oru vibhavamayi eee daattaabes pravartthikkunnu. epittoppukalude pravachanathinum vishakalanathinum sahayikkunna upakaranangalum daattaabesil undu.
marsupiyalukalkkum monotreamkalkkumulla (idmm) immunom daattaabes.
ariyappedunna ellah marsupial, monotream rogaprathirodha jeanteyum daatta eee daattaabesil undu. sasthanikalude prathirodhasheshiyude parinamam padikkunna rogaprathirodha vidagtharkkum gaveshakarkkum ithu oru vibhavamayi pravartthikkunnu.
immunology database vishakalana portalum (import).
rogaprathirodha daattayude punarupayogam prolsaahippikkunnathi vikasippichedutha oru daattaabes. california-saan francisco sarvakalashaala, stanford sarvakalashaala, pothu sarvakalashaala, technion-israel instittyoott oof teknolaji, northrop grummon ennividangalile gaveshakar thammilulla pankaalithamaanithu. rogaprathirodhashaasthravumaayi bandhapetta 400-ladhikam padanangalude phalangal ithil ulppedunnu.
immunological genome project (iii. emm. jii. enn).
eliyude rogaprathirodha samvidaanathekkurichulla padanavumaayi bandhapetta daatta adangiyirikkunna oru pothu vibhavamaan eee daattaabes.

