
sophosbuvir/velpattaasveer

muthirnnavaril heppattaitis sii chikilsaykkulla oru nischitha-doses kompineshan marunnaan epclusa enna brand naamatthil vilkkunna sophosbuvir/velpattaasvir. ithu sophosbuvir, velpattasveer enniva samyojippikkunnu. heppattaitis sii janithakaghadanakalaaya onnu muthal aarr vare 90 sathamaanathiladhikam falapradamaanu. sirosis allengil echuaivi/aids ullavaril heppattaitis sick ithu pravartthikkunnu. ithu vaayil ninnaan edukkunnathu.
2020 maarchil, aarr vious athil kooduthalumulla kuttikalil heppattaitis sii vairas (echsivi) chikilsikkaan sophosbuvir/velpattaasvir amerikkayil upayogikkaan amgeekaaram nalki, allengil kuranjathu 37 poundu (17 kilogram) bharamullah aarr echsivi genodypeukalil eathenkilum-allengil strainukal-sirosis (karal rogam) allengil neriya sirosis illaathe. aarr vious athil kooduthalumulla allengil kuranjathu 37 poundu bharamullah gurutharamaaya sirosis ulla kuttikalude chikilsaykkaayi ribaavirinumaayi samyojippichu sophosbuvir/velpattaasvir soochippikkunnu.
eee kompineshan pothuve nannayi sahikkappedunnu. thalavedana, ksheenam, urakkamillaayma, ookkaanam ennivayaanu saadhaarana paarshwafalangal. garbhinikalaya sthreekalilum mulayoottunna samayathum eee kompineshan padichittilla. heppattaitis bii baadhichavaril kooduthal paricharanam aavasyamaanu. sophosbuvir pravartthikkunnathu ens5bii proteine thadayunnathiloodeyum velpattaasvir pravartthikkunnathu ens5eiii proteine thadayunnathiloodeyum aanu.
sophosbuvir/velpattaasvir 2016 ll amerikkayilum europilum vaidyashaasthraparamaaya upayogathinaayi amgeekarichu. ithu lokaarogya samghadanayude avashya marunnukalude pattikayil ulppedunnu.
medical upayogangal.
genotype 1-6 chronic heppattaitis sii vairas (echsivi) anubaadhayulla muthirnnavarkk orotta gulika rejimen upayogikkunnu.
ethirvashangal.
karal ensaimukalaaya saip2bii6, saip2sii8 allengil saip3eiii4 ennivayude sakthamaaya induserukalumaayo allengil pii-glycoproteinumaayo sophosbuvir/velpattaasveer samyojippikkunnath virudhamaanu, kaaranam atharam padaarthangal marunninte falaprapti kurachekkaam.
paarshwafalangal.
thalavedana, ksheenam, ookkaanam ennivayaanu saadhaarana paarshwafalangal (10 sathamaanathiladhikam aalukalil). padanangalil, 3 sathamaanam rogikalil gurutharamaaya paarshwafalangal anubhavapettu, prathikoola sambhavangal kaaranam 0.20 sathamaanam perr therapy avasaanippichu. placibo upayogichu chikilsicha aalukalil samanamaaya aavruthiyilaanu eee phalangal sambhavichathu.
charithram.
banglaadeshile beekkan farmaceuticals sophoswell enna vyapara naamatthil oru generic pathipp uthppannam avatharippichu. peeples republic oof banglaadeshile aarogya kudumbakshema manthraalayathile dayaraktarettu oof drugg administrationil ninnu beekkanin amgeekaaram labhichu.
gileyad sciences enna farmaceutical kambaniyaanu sophosbuvir/velpattaasvir vikasippikkukayum yuu. ezz. amgeekaaram nalkukayum cheythath.ezz. muthirnnavarile vittumaaraatha heppattaitis sii vairas anubaadhayude chikilsaykkaayi 2016 juunil phudu aandu drugg administration (fda) europian yooniyanil 2016 joolaiyil ithu amgeekarichu.
12 aazhchathe chikilsaykkaayi sophosbuvir/velpattaasveerinte surakshyum falapraptiyum sirosis illaathe allengil compensated sirosis (laitt sirosis) upayogichu 1,558 vishayangalude moonnu ghatta klinikkal pareekshanangalil vilayiruthi. sophosbuvir/velpattaasvir sweekarichavaril <aii. dii. 1> sathamaanam perkkum chikitsa poortthiyaakki 12 aazhchakalkk sesham rakthathil vairas kandethiyittillenn phalangal theliyichu, ithu vishayangalude anubadhakal sukhappettathaayi soochippikkunnu. sophosbuvir/velpattaasveerinte surakshyum falapraptiyum decompensated sirosis (mithamayathum kadinavumaaya sirosis) ulla 267 vishayangalude klinikkal trialil vilayiruthukayum avaril 87 perkku 12 aazhchathekku ribaavirinumaayi samyojippichu sophosbuvir/velpattaasveer labikkukayum cheythu, eee vishayangalil 94 sathamaanam perkkum chikitsa poortthiyaakki 12 aazhchakalkk sesham rakthathil vairas kandethanaayilla.
pharmacokinetics (shareeram oru marunnine engane agiranam cheiyunnu, vitharanam cheiyunnu, svayam ozhivaakkunnu), echu. sii. vii genodypeukal 1,2,3,4 allengil 6 anubaadhayude chikilsaykkaayi 12 aazhchathekku vaamozhiyayi edutha sophosbuvir/velpattaasveerinte surakshyum falapraptiyum oru ooppan label, multisenter klinikkal trialil sthaapichu, athil motham 173 chikitsa-naivu, chikitsa parichayasambannaraaya aarr vious athil kooduthalumulla kuttikal sirosis illaathe allengil neriya sirosis ullavar. muthirnnavarumaayi thaarathamyappeduthumbol pediatric vishayangalil pharmacokineticsil ardhavathaaya vyathyasangalonnum kandilla. surakshyum falapraptiyum muthirnnavaril nireekshichathumaayi thaarathamyappeduthaavunnatha. 12 num 17 num idayil praayamulla 102 vishayangalil, genotype 2,3,4,6 ennivayulla vishayangalil genotype 1, <aii. dii 1> ulla 93 sathamaanam vishayangalil chikitsa poortthiyaakki 12 aazhchakalkk sesham rakthathil kandethaan kazhiyunna vairas illaayirunnu, ithu vishayangalude anubadha sukhappettuvennu soochippikkunnu. echu. sii. vii. janithakaghadanayulla 6 muthal 11 vayass vare praayamulla 71 peril 1,2,3 allengil 4, genotype ulla 93 sathamaanam, genotype 3 ulla 91 sathamaanam, genotype 2, genotype 4 ennivayulla <aii. dii. 1> ennivayil chikitsa poortthiyaakki 12 aazhchakalkk sesham rakthathil vairas kandethiyitla.
aarr vious athil kooduthalumulla pediatric vishayangalil echsivi genotype 5 chikilsaykko sirosis illaathe kuranjathu 37 poundu bharamullatho allengil neriya sirosis ullatho aaya sophosbuvir/velpattaasvirinte surakshyum falapraptiyum muthirnnavarilum echsivi genotype 1,2,3,4 allengil 6 anubaadhayulla pediatric vishayangalilum sophosbuvir, velpattaasvir exposureukal pinthunaykkunnu. gurutharamaaya sirosis ulla echu. sii. vii genotype 1,2,3,4,5 allengil 6 anubaadhayulla pediatric vishayangalkkulla dossing shupaarshakale pinthunaykkaan samanamaaya daatta upayogichu.
aarr vayassinu thaazheyullavaril sophosbuvir/velpattaasveerinte surakshyum falapraptiyum sthaapichittilla.
yuu.ezz. phudu aandu drugg administration (eph. dii. eiii) sophosbuvir/velpattaasvir munganana avalokanathinte apeksha anuvadikkukayum gileyad sciences, ink.