
c10orf67

sii10oorf115, link01552, ba215c7.4 ennum ariyappedunna chromosome 10 ooppan reeding frame 67 (sii10oorf67), savisheshathayillaatha manushya protein-coding jeenaanu. krons rogam, sarcoidosis thudangiya vittumaaraatha koshajwalana thadassa rogangalumaayi ithinte janithaka polymorphisangalum mattu niravadhi jeenukalum thammil saadhyamaaya bandhamundennu niravadhi padanangal soochippikkunnu.
jeane.
eee jeane 14,2366 bays jodikalil vyaapichukidakkunnu, chromosome 10-nte mainus (-) allengil sense strandile 10p12.2 locusil sthithicheyyunnu. ithu jeane aamk 3-nte mukalilekkum kiya 1217-nte thaazhekkum chuttappettirikkunnu. eee jeenukal yathaakramam c10orf67-ll ninnu ekadesham 150,000 bipi, 350,000 bipi ennivayaanu. 
traanskript.
13 traanskript vakabhedangal encode cheiyunna 23 badal spliesed exonukalundu. praadhamika traanskript, 2943 bipi maathram, oorthologukalkkidayil nannayi samrakshikkappedunnilla, pakaram, 3417 bipi enna x2 vakabhedathinu orthologas proteinukalumaayi valare valia swathuamundu. eee x2 traanskript vakabhedathil 15 exonukalundu, avaa 551 amino aasidukalude polypeptide nalkunnu.
protein.
pothuvaaya swathukkal.
manushya proteinukalude saraashariyekkaal (6.81) aiso electric pooyint valare kooduthalaanu.
ghadana.
proteente pravachikkapetta oru moonnaam ghadana valathuvashath kaanikkunnu. niravadhi koyil pradeshangalulla neelamulla alfa-helixukalum enn-sii-terminal attangalkk athirvashathulla proteente attathu praadeshikavalkkaricha beetta straandukalum ithu adayaalappeduthunnu.
aavishkaaram.
shareerathile mikka koshangalilum c10orf67 mithamaayi (50-75%) prakadippikkunnu. ennirunnaalum, jeane expressionil interlookkin-13 (ail-13) nte swaadheenam charcha cheiyunna enn. sii. bii. aii jiyoyekkurichulla oru padanatthil, airway epitheeliyayil ail-13 nte saannidhyathil protein expression poojyamaayi kuranjathaayi kandethi.
subsellular localisation.
proteinil mitocondrial signal pepttaid adangiyirikkunnu, ithu mitocondrial matrixilekku praadeshikavalkkarikkunnu. subsellular localisation software upayogichulla vishakalanam eee kandethal sthireekarichu. ennirunnaalum, chila oorthologukal nucleusil praadeshikavalkkarikkuppedu pravachikkapettu. manushya proteininte uyarnna aiso electric pooyint mitocondrial maatriksinte uyarnna piechu kaaranam mitocondrial localisationu kooduthal thelivukal nalkunnu.
vivarthanaananthara mattangal.
villal sittukal.
mitocondrianilekku praadeshikavalkkarichathinum 36 amino assid enn-terminal signal pepttaid neekkam cheiyunnathinaayi protein thudakkathil pilarunnu.
phosphorylation.
pravachikkapetta niravadhi phosphorylation sittukal undu, ennirunnaalum thrionin 69-ll pareekshanaathmakamaayi sthireekaricha oru phosphorylation saitt undu. mattu phosphorylation sittukal chuvadeyulla protein rekhaachithrathil samgrahichirikkunnu.
sumoilation.
c10orf67-ll pravachikkapetta anchu sumoilation sittukal undu. iva inipparayunna pattika samgrahikkunnu
homology parinaamavum.
parinamam.
c10orf67 nuu ariyappedunna paaralogukalonnumillengum yookkaariyottukalkkull niravadhi oorthologukalundu, koodaathe akasherukkaleppole vidooramaayi bandhappettirikkunna speesheesukalumaayi kaaryamaaya swathuam nilanirthunnu. chila thirichariyal vivarangalumayi niravadhi thiranjeduttha oorthologukal chuvade pattikappedutthiyittundu. 
parinamam.
sii10oorf67-nte parinaama nirakk fibrinogen, cytochrome sii ennivayumaayi thaarathamyam cheythu, avaa yathaakramam vegathilum mandagathiyilumulla parinaama nirakkukale prathinidheekarikkunnu. athath proteinukalude parinaama nirakk nirnnayikkunnathinaayi fibrinogen, cytochrome sii oorthologukal ennivaye prathinidheekarikkunnathin pattikayile boold speesheesukal thiranjedutthu.
mikka proteinukaleyum pole oru rekheeya pravanathayekkaal oru laghuganaka pravanatha pinthudarunnathil c10orf67-nte parinaama nirakk valare kauthukakaramaanu.
klinikkal praadhaanyam.
sarcoidosis.
sii10oorf67-nte pravartthanam anjjaathamaanengilum, ail-13-maayi athinte edapedalukal sarcoidosisil sii10oorf67-nte punk soochippikkunnu, kaaranam eee rogathil vividha interlookkinukal ulppedunnu.
kyaansar.
jeane eksprashanekkurichulla vividha gadakangal parishodhikkunna niravadhi enn. sii. bii. aii jio profileukal sii10oorf67 vividha cancer tissuekalil vyathyastha thalangalil prakadippikkunnathaayi kaanikkumbol, mitocondrial localisation oru klinikkal pravarthanathekkurichu kurachu ulkkaazhcha nalkiyekkaam. koshangalude vyaapanathil mitocondriaykku chila swaadheenamundennu theliyikkappettittund. kosha vyaapanathil ninnulla uyarnna oorjja aavasyam kanakkiledukkumbol, mitocondria koshachakratthil oru punk vahikkamennum mitochondriyayilekku praadeshikavalkkarikkuppadu sii10oorf67-nuu ithilum oru pankundaakaam ennum niravadhi sidhaanthangalundu.

