phosphestrol

purushanmaaril prostettu cancer chikilsayil upayogikkunna eestrajan marunnaan honvan enna brand naamatthil vilkkunna diethylstilbestrol diphosphate (despy) ennum ariyappedunna phosphestrol. divasathil orikkal muthal aazhchayil orikkal vare allengil divasathil orikkal vaayiloodeyo pathukke intravinus infusion vazhiyo ithu nalkunnu.
phosphestrolinte paarshwafalangalil ookkaanam, chharddi, hridayasambandhamaaya sankeernathakal, raktham kattapidikkal, edema, jananendria charmma prathikaranangal enniva ulppedunnu. phosphestrol oru eestrajan aanu, athinaal eastradiol polulla eestrajanukalude jaiva lakshyamaya eestrajan resepterinte agonistaanu. ithu diethylstilbestrol oru prodragaayi pravartthikkunnu.
1941ll pettant nediya phosphestrol 1955ll vaidyashaasthraparamaaya upayogathinaayi avatharippikkappettu. munbu ithu lokamembaadum vyaapakamaayi vipananam cheyyappettirunnu, ennaal ippol kurachu rajyangalil maathrame labhyamaayittulloo.
medical upayogangal.
castering-resistant prostettu kaansarinte chikilsayil uyarnna alavil eestrajan therapy oru roopamaayi phosphestrol upayogikkunnu. orkkiyektomi, gonadotropin-release cheiyunna hormon modulettarukal, nonstiroyidal aanti androjan thudangiya mattu edapedalukalulla therapic sesham mettaastesukalude purogathi sambhavichukazhinjal ithu cherkkunnu. prostettu cancer ulla purushanmaaril gonadotropin-release cheiyunna hormon agonist therapy thudakkathil testostiron jwalikkunnathu thadayaanum phosphestrol upayogichittundu.
prostettu cancer ulla purushanmaaril 5 muthal 10 divasam vare chikitsa kaalayalavilekku oru manikkoor dairkhyamulla mandagathiyilulla intravinus infusion vazhi prathidinam 600 muthal 1200 milligram vare alavil phosphestrol soodiyam nalkunnu. ithinethudarnnu, ithu 10 muthal 20 divasam vare prathidinam 300 milligram enna alavil nalkunnu. 300 muthal 600 milligram vare phosphestrol sodiyathinte attakuttappanikal aazhchayil naalu thavana nalkaam. ithu kramena aazhchayil oru 300 muthal 600 milligram vare dosaki kuraykkaan kazhiyum.
prostettu cancer chikilsayil oru divasam moonnu thavana 360 muthal 480 milligram vare alavil thudakkathil phosphestrol soodiyam oru paridhivare vaayiloode upayogikkunnu. 120 muthal 240 milligram vare attakuttappanikal divasathil moonnu thavana upayogikkaam, kramena prathidinam 240 milligraamaayi kuraykkaam.
labhyamaya foomukal.
phosphestrol intravinus administreshanulla parihaarangaludeyum ooral administreshanulla gulikakaludeyum roopathil labhyamaan.
paarshwafalangal.
80 sathamaanam rogikalilum ookkaanam, chharddi (25ll 1, allengil 4 sathamaanam, maranathinu kaaranamaakunnu), hridayasambandhamaaya sankeernathakal (phosphestrol ulla 18 sathamaanam, adriamycin ulla 2 sathamaanam), thrombosis (25ll 2, allengil 8 sathamaanam), edema (44 sathamaanam moothravisarjjana chikitsa aavasyamaanu), jananendria mekhalayile pollal, chorichil allengil vedana polulla charmma prathikaranangal (40 sathamaanam) ennivayaanu phosphestrolinte paarshwafalangal. koodaathe, sareerabhaaram vardhikkuka, sthreevalkkaranam, gynaecomastia enniva sambhavikkam.
farmacology.
pharmacodynamics.
eestrajan resepterukalude oru agonistaanu phosphestrol. ithu svayam nishkriyamaanu, koodaathe diethylstilbestrol oru prodragaayi pravartthikkunnu. diethylstilbestroll samaanamaayi, phosphestrolinu sakthamaaya antigonadotropic efakttukal undu, koodaathe purushanmaaril testostironinte alavu shakthamayi adichamarthunnu. chikitsa aarambhich 12 manikorinullil ithu kaastrett paridhiyilekku testostironinte alavu kuraykkunnu. prostettu grandhiyile nerittulla cytotoxic efakttukal vazhi phosphestrol mattu samvidaanangal vazhiyum pravarthichekkaam.
pharmacokinetics.
phosphestrolinte pharmacokinetics padikkappettittund.
rasathanthram.
stilbestroll groupile synthetic nonstiroyidal eestrajanaanu phosphestrol. ithu oru eestrajan estaraanu; prathyekichum, ithu diethylstilbestrol diphosphate estaraanu.
phosphestrol swatantra aditharayaayum tetrasodium uppayum nalkunnu. dosinte thulyathayude kaaryatthil, 300 milligram anhydrus phosphestrol soodiyam ekadesham 250 milligram phosphestrolinu thulyamaanu.
pashuvaidyathil upayogikkaan saadhyathayulla deerghakaala eestrajanaayi phosphestrolinte oru polymeraaya polyeithylstilbestrol phoosphett vikasippicheduthuve orikkalum vipananam cheyyapettilla.
charithram.
1941-ll aadyamaayi pettant nediya phosphestroline saahithyathil huggins paraamarshichu. 1952 octoberil aarambhicha attin koottangalum sahapravarthakarum prostettu cancer chikilsayil intra veenas cancer phosphestrol padikkukayum 1955 ll avarude kandethalukal prasidheekarikkukayum cheythu. 1955 ll yathaakramam stilfostrol, ezz. tii 52 ennee brand namangalil amerikkayilum fraansilum yathaakramam phosphestrol aadyamaayi vaidyashaasthra upayogathinaayi avatharippichu.
samoohavum samskaaravum.
pothuvaaya perukal.
"phosphestrol" ennathu marunninte pothuvaaya peraanu, koodaathe "diethylstilbestrol diphosphate" ennathu athinteyum "phosphestrolo" ennathu athinteyum aanu. ithu "stilbestroll diphosphate" ennum ariyappedunnu. "phosphestrol soodiyam" athinte aanu.
brand perukal.
phosphestrolinte brand namangalil sittanal, defestilben, honovan, honvan, honwall, honvon, phosphostilben, fostrolin, ezz. tii 52, stilbettin, stilbol, stilbostaattin, stilfostrol, vajestrol enniva ulppedunnu.
labhyatha.
america, canada, europe, eshya, laattin america, dakshinaafrikka thudangi lokathinte mattu pradeshangal ulppede lokamembaadum phosphestrol vyaapakamaayi vipananam cheyyappettittund. ennirunnaalum, innu, bangladesh, eejipt, india, omaan, tunisia ennivayulppede kurachu rajyangalil maathrame ithu labhyamaayittulloo.

