
ambarappulla

marginal soonn lymphoma (emm. ezz. ell), follicular lymphoma (eph. ell.) ennivayude chikilsaykkulla cancer virudha marunnaan uconic enna brand naamatthil vilkkunna ambralisib. ithu vaayil ninnaan edukkunnathu.
paii3keey-deltta, keysin kainas sike1-epsailon ennivayulppedeyulla kainas inhibittaraanu ambralisib.
creatinine vardhikkuka, vayarilakkam-kolaittis, ksheenam, ookkaanam, neutropenia, transaminase elevation, musculoskelital vedana, anaemiya, thrombocytopenia, upper respiratory tract anubadha, chharddi, vayaruvedana, vishapp kurayuka, chorichil enniva ettavum saadhaaranamaaya paarshwafalangalil ulppedunnu.
2021 februvariyil amerikkayil medical upayogathinu ambralisibinu thwarithappeduthiya amgeekaaram labhichu. ennirunnaalum, mothatthilulla nilanilppilekku nayikkunna deerghakaala paarshwafalangal vardhikkunnathinekkur aashankakal kaaranam ithu odaak avalokanathinte roopathil eph. dii. eiii parisodhana vardhippichathinaal ithu us vipaniyil ninnu pinvalichu.
medical upayogangal.
2022 eprilil, marginal soonn lymphoma, follicular lymphoma ennivayude chikilsayil amgeekritha upayogathinaayi uconic (ambralisib) vilppanayil ninnu swamedhayaa pinvalikkumennu tiji therapeutics prakhyaapichu. koodaathe, vittumaaraatha lymphocytic leukemia (cll), small lymphocytic leukemia (sll) ennivayude chikilsaykkaayi "yuu 2" rejimen ennariyappedunna yublittaksimabinoppam ambralisib upayogicha biologics licenses application (bla) supplemental nyoo drugg application (snda) kambani pinvalichu. oesile asanthulithaavasthaye chithreekarikkukayum vardhippikkukayum cheiyunna yoonitti-cl moonnaam ghattathil ninnulla mothatthilulla athijeevana (oesu) daattaye adisthaanamaakkiyullathaayinu theerumaanam.
kuranjathu oru munkaala aanti-sidi20 adisthaanamaakkiyulla rejimen labhicha relapsed allengil refractory marginal soonn lymphoma (emm. ezz. ell) ulla muthirnnavarkkum kuranjathu moonnu munkaala systemic therapy line labhicha relapsed allengil refractory follicular lymphoma (eph. ell.) ulla muthirnnavarkkum ambralisib soochippikkunnu.
prathikoola phalangal.
anubadhakal, neutropenia, vayarilakkam, pakarchavyaadhiyallaatha vankudal, hepatotoxisity, kadinamaaya thwakk prathikaranangal ennivayulppedeyulla prathikoola prathikaranangalkk munnariyippukalum munkaruthalukalum nirddeshikkunna vivarangal nalkunnu.
charithram.
ithu vittumaaraatha lymphocytic leukemia (cll) kku klinikkal padanangalkku vidheyamaayittundu. moonnu varshathe daatta (follicular lymphoma, dlbcl ulppede) 2016 juunil prakhyaapichu. ithu maanttil sell lymphoma (mll), mattu lymphomakal polulla vividha leukemia, lymphomakal ennivayude samyojana pareekshanangalilaan.
ambralisibinu yuu. ezz. break throo therapy padavi nalki.ezz. prathyekamaayi amgeekritha chikilsakalillaattha oru tharam canceraaya marginal soonn lymphoma (emm. ezz. ell) ullavaril upayogikkunnathinu phudu aandu drugg administration (eph. dii. eiii).
eph. dii. eiii amgeekaaram rund single aam cohortukal adisthaanamaakkiyullathaanu, oru ooppan-label, multy-sentar, multy-alcohort trial, utx-tgr-205 (enn. tii. tii. 2793583), marginal soonn lymphoma (emm. ezz. ell) ulla 69 pankaalikalil, kuranjathu oru munkoor therapy labhichavaril, oru aanti-sidi20 adangiya rejimen ulppede, kuranjathu rund muun systemic theraappikalkk sesham follicular lymphoma (eph. ell) ulla 117 pankaalikalil. ambaralishibinu vendiyulla apekshaykku marginal soonn lymphoma (emm. ezz. ell) indication emm. ezz. ell, follicular lymphoma (eph. ell) ennivayude chikilsaykkaayi anatha marunnu padaviyum munganana avalokanam nalki.
samoohavum samskaaravum.
niyamaparamaaya padavi.
2022 juunil, suraksha aashankakal kaaranam, us phudu aandu drugg administration (fda) uconic (ambralisib)-nulla amgeekaaram pinvalichu.
yoonitti-cl klinikkal trialil ninnulla update cheytha kandethalukal kaanikkunnath uconic sweekarikkunnavaril maranasadhyatha vardhikkunnu ennaanu. thalphalamaayi, uconic chikilsayude apakadasadhyathakal athinte gunangalekkaal kooduthalaanennu fda nirnnayichu. eee nischayadaarthyathinte adisthaanathil, emm. ezz. ell, eph. ell ennivayile amgeekritha upayogangalkkayi vipaniyil ninnu euconic swamedhayaa pinvalikkunnathayi marunninte nirmmathaavaaya tii. jii. therapeutics prakhyaapichu.

