
soodiyam stibogluconet

leshmaniasis chikilsikkaan upayogikkunna marunnaan pentostaam enna brand naamatthil vilkkunna soodiyam stibogluconet. ithil thwakk, visaral, mucosal tharangalude leshmaniasis ulppedunnu. ennirunnaalum, prathirodhatthile prasnangal kaaranam miltefosin, paramycin, liposomal amphotericin bii ennivayude chila samyojanam shupaarsha cheyyappedaam. kuthivayppiloodeyaanu ithu nalkunnathu.
vishapp kurayuka, ookkaanam, peshi vedana, thalavedana, ksheenam enniva ulppedunna paarshwafalangal saadhaaranamaanu. gurutharamaaya paarshwafalangalil kramarahithamaya hridayamidippu allengil pancreatitis ulppedaam. garbhakaalath mattu chila oopshanukalekkaal soodiyam stibogluconet surakshithamalla. mulayoottunna samayat upayogikkukayaanenkil ithu oru prashnathinum kaaranamaakumenn vishwasikkappedunnilla. pentavalant antimonial vibhaagathil pedunna marunnaan soodiyam stibogluconet.
soodiyam stibogluconet 1937 muthal thanne padikkappettittund, 1940 muthal ithu vaidyashaasthraparamaaya upayogathilaanu. lokaarogya samghadanayude avashya marunnukalude pattikayil ithu ulppedunnu. amerikkayil ithu roga niyanthrana kendrangalil ninnu labhyamaan.
paarshwafalangal.
soodiyam stibogluconet sirakalkku valareyadhikam vishaamsham nalkunnu. kurachu dosukalkku sesham marunnu kuthivaykkunnathinulla oru sira kandethunnathu valare budhimuttaayirikkum ennathaanu praayogika prashnangalilonn. peripherally insert cheytha central katheettar (pii. sii. sii) cherkkunnath prashnam thadayunnilla, pakaram athu vashalakkum pii. sii. sii laininte gathiyilulla muzhuvan sira veekkam, thrombose enniva aakam. soodiyam stibogluconetint valia alavu palappozhum nerppicha laayanikalaayi nalkunnu.
pancreatitis marunninte oru saadhaarana doshakaramaaya falamaanu, koodaathe serem amylase allengil lipace aazhchayil randuthavana nireekshikkanam; amylase saadhaaranathekkaal naaliratti kurravaanengil chikitsa nirthendathilla; amylase katt-oof cheiyunnathinekkaal uyarnnaal, amylase saadhaaranathekkaal erattiyiladhikam kurayunnathuvare chikitsa thadassappedutthanam, thudarnnu chikitsa punaraarambhikkaan kazhiyum. hridayachaalanaathmaka thadassangal saadhaaranamalla, ennaal marunnu kuthivaykkumbol electrocardiograph (isiji) nireekshanam nallathaanu, marunnu nirtthiyatho infusion nirakk kuranjatho aayathin sesham vegathil mattangal maarunnu.
marunnu intramuscularaayi nalkaam, pakshe eee vazhi nalkumbol ithu valare vedanaajanakamaanu. thwakk leshmaniasis chikithsikkumbozhum ithu intraalisanalaayi nalkaam (i.iii., rogabadhithamaaya charmmatthinte bhaagathekku nerittu kuthivaykkunnu) veendum, ithu valare vedanaajanakamaanu, koodaathe intravinus administreshanekkaal mikacha phalangal nalkunnilla.
soodiyam stibogluconet vishapp kurayuka, vaayile loha ruchi, ookkaanam, chharddi, vayarilakkam, thalavedana, ksheenam, sandhi vedana, peshi vedana, thalakarakkam, anaphylaxis ennivaykkum kaaranamakum.
dossing.
soodiyam stibogluconet yunaittad kingdatthil pentostaamaayi labhyamaan, avide ithu glaxosmithcline nirmmikkunnu. centers phoor disease kantrol aandu preventionil (cdc) ninnu amerikkayil perulla rogiyude adisthaanathil ithu labhyamaan.
leshmaniasis chikilsikkunnathinulla dosage rejimentukal vikasichathode, therappiyodulla prathikaranasheshiyillaathine cherukkunnathinaayi antimoniyude dainamdina dose therapy dairkhyavum kramena vardhippichu. 1980kalil, prathidinam 20 milligram/kilogram (10 milligram/kilogram/divasathinu pakaram) antimony upayogikkaan shupaarsha cheythirunnu, ennaal paramavadhi prathidina doses 850 milligram mathramaayirunnu. sameepakaala gaveshanangal sameepakaala falapraapthiyudeyum vishaamshathinteyum adisthaanathil eee 850-milligram niyanthranam neekkam cheyyanamennu nirddeshichittundu. avarude gaveshanathil innuvareyulla thelivukal soochippikkunnathu, prathidina dosinu uyarnna paridhiyillathe pentavalant aantimaniyude 20 milligram/kilogram/divasam enna rejimen kooduthal phalapradavum kuranja dainamdina dosukal ulla rejimensukalekkaal ganyamaayi vishamshamullathalla. ellah tharatthilulla leshmaniasisinum prathidinam 20 milligram/kilogram pentavalant antimony upayogichu chikilsikkaan shupaarsha cheiyunnu. thwakk leshmaaniyaasisinte chikitsa saadhaaranayaayi 20 divasavum visaral, mucosal leshmaniasis 28 divasavum neendunilkkum.
soodiyam stibogluconetint alavu mandagathiyilulla intravinus infusion vazhiyaan (kuranjathu anchu minittengilum hridaya nireekshanathode). chumayo madhya nenchuvedanayo undengil kuthivayppu nirtthunnu. randaam lokamahaayudhasamayathu sisili adhinivesha samayat sakhyasenamgangalkk adiyanthiramaayi chikitsa aavashyamullappol leonard goodwin chemotherapic soochika sthaapichu.
chikilsayude dairkhyam saadhaaranayaayi 10 muthal 21 divasam vareyaanu, ithu "leishmania" yude inatheyum anubaadhayude tharatheyum (thwakk allengil visaral) aasrayichirikkunnu.
raasaghadana.
soodiyam stibogluconetint raasaghadana alppam avyakthamaanu, mukalil kaanichirikkunna ghadana aadarshaparamaanu. eee vaividhyathin praadhaanyamillenkilum athinte laayanikalil onniladhikam antimony samyukthangal adangiyirikkaam. sajeevamaaya eee inathil orotta antimony kendram maathrame ulloo ennu anumaanikkappedunnu.
pharmacokinetics.
pentavalant antimony shareerathil adinjukoodunnathaayi kaanapedunnilla, ithu vrukkakalaal puranthallappedunnu.
pravartthana samvidaanam.
soodiyam stibogluconetint samvidaanam nannayi manassilakkappettillettim labhyamaya eiii. tii. pii, jii. tii. pii ennivayil kuravu varuthunnathiloode macromolecular synthesis thadayunnathil ninnaan ithu undaakunnathenn karuthappedunnu, ithu citric assid saikilinteyum glycolysisinteyum prathirodhatthinu randaam sthaanathaayirikkaam. berman thudangiyavar. leishmaniasis mexicana" yill stibogluconetint phalangal padikkukayum purine nucleoside triphosphateukalil (eiii. tii. pii, jii. tii. pii) oru label ulppeduthunnathil kuravu varuthukayum athupole thanne purine nucleoside mono, dye phosphettukal (ampere, jii. emm. pii, eiii. dii. pii, jii. dii. pii) ennivayilekku label ulppeduthunnathil vardhanavu varuthukayum cheythu.