
membranome daattaabes

membranome daattaabes "homo sapiens", "arabidopsis taliana", "dictiostelium dyscoidium", "sacharomysus serivisiya", "escherichiya koolii", "methanocaldococcus jannashi" ennivayil ninnulla 6000-ladhikam single-paas (bittopik) transmembran proteenukalekkurichulla gadanaaparavum pravarthanaparavumaaya vivarangal nalkunnu. oru biological membraninte ethirvashangalil sthithi cheiyunna proteente vellathil layikkunna domainukale bandhippikkunna orotta transmembron alfa-helix bittopik membran proteinukalil adangiyirikkunnu. multisellular jeevikalile koshangal thammilulla signal transduction, ashayavinimayam ennivayil eee proteinukal pathivayi earppedunnu.
membranil praadeshikamaayi krameekarichirikkunna transmembran alfa-helikkukalude computational aayi janarettucheytha trimana modalukal, topology, intra sellular localisationukal, amino assid sequenceukal, domaine architecture, functional annotation, protein dattaa baankil ninnu labhyamaya pareekshanathmaka gadanakal ennivayulppede vyakthigatha proteenukalekkurichulla vivarangal daattaabes nalkunnu. bittopik proteinukale 15 functional klaasukalaayum 700-ladhikam structural suuppar faamilikalaayum 1400 faamilikalaayum tharamthirikkukayum vividha faamilikalaayi tharamthirikkappetta bittopik protein complexukalude 3D gadanakalaayum ithu nalkunnu. 
tmdoke prograam upayogichu srishtikkappetta vividha jeevikalil ninnulla bittopik proteinukalude tm α-helikkukal roopeekaricha 2000 ladhikam samanthara homodimerukalude 3dii modalukal randaamathe membranome pathipp nalkunnu. ekadesham 600 proteinukalkkaayi labhyamaya pareekshanathmaka daattayumaayi thaarathamyappeduthunnathile homodimerukalude modalukal parishodhichu. daattaabesil transmembran helisukalude daunlodu cheyyaavunna coordinate fayalukalum kanakkukoottappetta membran athirukalulla avayude homodimerukalum ulppedunnu. membranome 3 pathippil alfafold 2 srishticha modalukal ulppedunnu.
vyakthigatha alfa-helixukaludeyum membranukalile avayude diameric complexukaludeyum modalinginaayi vikasippichedutha anubandha web serverukal, efmap, tmdoke ennivayilekku daattaabes websait praveshanam nalkunnu. bittopik membran proteinukalude pareekshanathmakavum bioinformatics padanangalilum daattaabesukalum web serverukalum upayogichu.