sephip

chromosome 10 ooppan reeding frame 71-ll kaanuka jeane encode cheytha oru proteinaan cardiac-enriched cardiac-enriched protein (sephip). eee jeane peshi tissuevilum hridaya tissuevilum mithamaayi prakadippikkunnuvennu praadhamikamaayi manassilaakkappedunnu.
jeane.
cytogenic locus 10q11.23 ll kaanapedunnu. c10orf71 chromosome 10-nullil 28294 bays jodikale (bipi) 49299193-49327487 bipi-yill encode cheiyunnu. ithu plus strandle sthithicheyyunnu, koodaathe mattu niravadhi jeenukalaal chuttappettirikkunnu.
marnah.
c10orf71-nte mrna shreniyil anukoolamaaya splies roopathil 3 exonukalum 10 stopp kodanukalum undu. rund badal splies foomukalkku 47,75 stopp kodanukal seekwansiludaneelam chitharikkidannirunnathil kooduthal sequence vivarangal labhikkunnathin avaa upayogichilla. vishakalanam cheytha pradhana splies roopathil 5 ', 3' yudiaariludaneelam tenne stopp kodanukal chitharikkidakkunnundaayu, athinaalaan eee splies phoom kooduthal vishakalanam cheyyaan upayogichathu. kaanuka-nte homo sapiens oorthoologinte mrna 5286 bipi neelamaayirunnu. 
protein.
c10orf71 encode cheytha sephip proteente pakwathayulla "homo sapiens" homologue 1435 amino aasidukal (AA) neelavum ekadesham 156.5 kda bhaaravumund. eee homologinu 5.94 enna aiso electric poyintaanullathu. "homo sapiens" muthal vishakalanam cheytha ettavum puthiya orthologue, "rincodon tharangal" vareyulla piechu moolyangalude paridhi 5.94-6.93 muthal, pinneedu oorthoologinte vyathichalanathil kramena vardhikkunnu. 
protein ghadana.
sephip transmembran allatha, layikkunna proteinaanennu pravachikkappedunnu. oorthologukaliludaneelam oru nuclear protein aanennu thikachum aathmavishwaasamulla ithu 91.3% aathmavishwaasamulla oru nuclear proteinaanennu pravachikkappedunnu. amino aasidukal <aii. dii. 1> ll ninnu sthithicheyyunna sephip protein shreniyil oru positteev charge klasttar kandethi. vishakalanam cheytha oorthologukaliludaneelam eee klasttar mithamaayi samrakshikkappettu. amino assid <aii. dii. 1> ll ninnu sthithi cheiyunna eee proteininte "homo sapiens" shreniyil oru mixed charge klasttarum kandethi, ennirunnaalum vishakalanam cheytha oorthologukaliludaneelam eee klasttar valareyadhikam samrakshikkappettilla. amino aasidukalaaya 163-169,116-1172 ennivayil sthithi cheiyunna taskpa enna oru aavarthana kramavum kandethi. eee protein prolinum serin sambushtavumaanu.
 
domainukalum rooparekhakalum.
anjjaathamaaya pravartthanatthinte (duf) oru domaine sephip protein shreniyil kandethi, duf 4585. amino assid 311-334 ll ninnulla "homo sapiens" protein shreniyil duf 4585 sthithicheyyunnu. vishakalanam cheytha oorthologukaliludaneelam duf 4585 valareyadhikam samrakshikkappettu. amino aasidukal 543-546 vyaapichukidakkunna vishakalanam cheytha protein shreniyil oru cheria vacvolar targetting motif (vaaku) kandethi.
protein ghadana.
pakwathayulla sephip proteinil nuclear localisation signalukal (enls), paatt 4 (aaa 382 ll aarkepike, aaa 640 ll arprke, aaa 1190 ll krk), paatt 7 (aaa 379 ll ppvrkpke, aaa 380 ll pdablyuviaarkepikedi) enniva adangiyirikkunnu. 
vivarthanaananthara mattangal.
amino aasidukal 116,120,139,165,468,470,844 ennivayil kaanapedunna protein shreniyil pravachicha ezhu glocknack oo-glycosylation sittukal undaayirunnu. niravadhi phosphorylation saittukalum eee shreniyil udaneelam chitharikkidakkunnu. amino assid 38ll oru propeptide villal saitt pravachichirunnu. amino aasidukal 599,890,1176 ennivayil moonnu pravachikkapetta sumoilation sittukal kandethi.
aavishkaaram.
kaanuka mrna hridaya, peshi, karal tissue (biology) ennivayil valareyadhikam prakadippikkunnathaayi kandethi.
aavishkaarathinte niyanthranam.
eee shreniyil 6 promotermaare kandethiyittundu. promoter gxp _ 6729162 nuu 1403 bp neelamundu. eee promoterinu mayosaittukalumaayi bandhappettava ulppede niravadhi transcription gadakangal undaayirunnu.
pravartthanam.
sephippinte pravarthanathekkurichu shaasthreeya vivarangal valare kuravaanu.
parasparaprathikarana proteinukal.
sefipumaayi (homo sapiens orthologue) samvadikkumennu pravachicha motham 25 proteinukal uthpaadippikkappettu. pravachicha edapedalukalil bhooribhaagavum sefipumaayulla shaareerika edapedalukalaayirunnu. affinity chromatography, microare vishakalanam, tandom maas spectrometry ennivayulppede ennaal ivayil maathram parimithappedaathe vividha samvidaanangaliloodeyaanu eee edapedalukal kandethiyathu. sephippinte parasparapravartthana proteenukalekkurichulla vishadaamshangalkku pattika kaanuka.
homologukal.
peralukal.
kaanuka jeeninu nilavil peraalogukalonnumilla.
oorthologukal.
praimettukal (11 enangal), elikal (8 enangal), lorasiatheria maamsabhojikal (14 enangal), plaasantal sasthanikal (38 enangal), sorapsida pakshikalum uragangalum (7 enangal), malsyangal (11 enangal) ennivayulppede vividha enangalil 68 oorthologukal kaanuka-ll undennu ariyappedunnu. uyarnna parirakshitha shrenikal praadhamikamaayi praimettukalil ninnullavayaan, eee enangalude aidantitti sathamaanam 90 sathamaanathil kooduthalaanu, athesamayam uragangal, pakshikal, malsyam thudangiya enangalkku aidantitti sathamaanam ≤30 sathamaanamaanu. vyathichalana theeyathikal, sequence dairkhyam, sequence aidantitti, oorthologukalude saamyam ennivayekkurichulla adhika vivarangalkk pattika kaanuka. kaanuka prokaariyottukal, archaea allengil fangasukalil kaanapedunnilla.
filogeny.
homo sapiensumaayi thaarathamyappeduthumbol vishakalanam cheytha oorthologukalkkaayi oru phylogenetic trea nirmmichu."ettavum puthiya vyathichalana inam" "rincodon tharangal" "allengil timingala sraavaanu".
parinaama nirakk.
c10orf71-nte vyathichalana nirakk fibrinogen allengil cytochrome sii-yekkaal vegathilaayirunnu.
klinikkal praadhaanyam.
sepsis anubhavicha asthikooda peshi koshangalil kaanuka-nte aavishkaaram kuranjuvennathinu thelivu nalkunna oru microare pareekshanam undaayirunnu. myotonic dystrophy ullavare nokkunna oru pareekshanatthil kaanuka-nte expression levelil klinikkal praadhaanyam kandethi. oru microare vishakalanam prostettu cancer ullavarilum kaanuka-nte expression level kuranjathaayi kaanikkunna phalangal nalki.

