immunoriative trypsinogen

navjata shishukkalude rakthathile immunoriactive trypsinogen (irt) alakkunnathu sistik fibrosis (cf)-nulla screening testaayi athivegam vardhichuvarunna upayogathinte oru vilayiruthalaanu.
sii. eph. ll, pancreatic dakttukalil ninnu mosham release undu. transinogen ennathu rakthathil kaanapedunna oru pancreatic ensaiminte mungamiyaanu, athu jananasamayath cf ullavaril bhooribhaagathilum uyarnnathaan, avarude mutation pancreatic mathiyo aparyaapthamo ennathu pariganikkathe. pancreatic naalangal bhaagikamaayi thadassappettathinaal cf ulla kunjungalil irtyude saandrata vardhikkunnu, ithu asaadhaaranamaaya ensime drainageilekku nayikkunnu. sistik fibrosisinte heterosaigas carrierukal uyarnna irtic kaaranamakum, athinaal ithu ottappedalil roganirnayam nadathunnilla.
yukeyil janikkunna ellah navjata sisukkaludeyum biochemical screeninginaayi edukkunna pathiv heale-prick rakthathilaanu irt alakkunnathu. navajaathashishukkalude parisodhanayil ("gutri testt") poortthiyaakkiya niravadhi parisodhanakalil onnaanith. austreliyayil sii. eph. roganirnayam nadathiyavaril 94 sathamaanam perkkum navjata screenil positteev aii. aarr. tii undennu ariyappedunnu. uyarnna irt (moolyangalude ettavum uyarnna 1 sathamaanam ennu nirvachikkappedunnu) ulla saambilukal pinneedu saadhaarana cf jeane mutationukalkkaayi parishodhikkunnu. oro kendrathinum alpam vyathyasthamaaya jeane paanal undu; nilavil ettavum saadhaaranamaaya jeenukalil 40-50 krameekarichirikkunnu. ennirunnaalum, ariyappedunna 2000-ladhikam mutationukal ullathinaal jeane paanal parisodhana idaykkide sii. eph. rogikalkku nashtamakum.
jeane parisodhanayil oru mutation kandethiyaal roganirnayam sthireekarikkaan sahaayikkunnathin avarkk oru vearp parisodhana undaayirikkum. sisukkalil vearp parisodhana samshayaaspadamaakaanulla saadhyatha kooduthalaanu, saadhaaranayaayi 5 kilograamil thaazheyullavaril ithu cheyyaarilla. vearp parisodhana positteev aanenkil kooduthal vipulamaaya jeane parisodhana pariganikkunnu. rund mutationukal kandethiyaal avaykku cf undennu kandethunnu.
yunaittad stetts testing protocolukal.
protocolukal kanakkanusarichu, sistik fibrosisinaayi immunoriactive trypsinogen (irt) adisthaanamaakkiyulla navajaathashishukkalude parisodhana paripaadikal raajyathudaneelam nadappaakkiyittund.  ennirunnaalum, nirddishta parisodhanaa protocol samsthaanangalkkanusarich vyathyaasappedunnu.  uyarnna irt levalukalulla sisukkalkku adhika diagnostic screening aavasyappedunnathinu munbu chila samsthaanangalil janana manikorukalilo divasangalilo orotta immunoriative trypsinogen parisodhana maathrame nadathendathulloo.  ivayil chilath sistik fibrosis-nirddishta janithaka vyathiyanangal thirichariyunnathinaayi dna screening upayogichu oru uyarnna irt phalathe pinthudarunnu.  mattu samsthaanangal kooduthal parisodhana aavasyappedunnathinu munbu rund aii. aarr. tii raktha parisodhanakal (onnu jananathinu thottupinnalum onnu randaazhchaykku sheshavum) nadathendathundu.  navajaathashishukkalkk asaadhaaranamaayi uyarnna alavilulla immunoriactive trypsinogen koodaathe/allengil positteev dna screening phalangal undennu kandethumbol, sistik fibrosis roganirnayam sthireekarikkunnathino thallikkalayunnathino vearp chloride parisodhanakal nadathunna prathyeka soukaryangalilekku ruffer cheiyunnu.

