grid 2

glutamate risapttar, ionotropic, deltta 2, glud 2, glardi 2, allengil δ2 ennum ariyappedunnu, manushyaril "grid 2" jeane encode cheiyunna oru proteinaan. eee protein glud 1 umm ionotropic glutamate resepterukalude deltta risapttar upavibhaagathil pedunnu. avarkk aampa, kainett, enmda subunitukalulla 14-24% sequence homology undu, pakshe avayude peru undaayirunnittum yadhaarthathil glutamatineyo mattu glutamate agonistukaleyo bandhippikkunnilla.
deltta eglarukal deerghakaalamaayi anatha resepterukalaayi kanakkaakkappedunnu, kaaranam avayude endogenous ligand anjjaathamaayirunnu. avaa glycineyum dii-serineyum bandhippikkumenn ippol vishwasikkappedunnu, pakshe iva chaanal thurakkunnathinu kaaranamakunnilla.
pravartthanam.
glud 2 adangiya resepterukal seribellathile purkinje koshangalil thiranjeduttha/pradhaanamaayum prakadippikkunnu, avide avaa synaptogenesis, synaptic plaastitti, motor ekopanam ennivayil pradhana punk vahikkunnu.
sii. bii. ell. enn. 1-maayi athinte enn-terminal domaininte prathipravartthanathiloode glud 2 synaptogenesis prerippikkunnu, ithu pree synaptic neurexinukalumaayi prathipravartthikkukayum cerebellar sinaapsukalkk kuruke oru paalam roopappeduthukayum cheiyunnu.
synaptic plaastiksile glude 2-nte pradhana pravartthanangal athinte intra sellular sii-terminus aanu nadathunnathu. ithu niyanthrikkunnath dii-serinaanu, ithu ligand-binding domainumaayi bandhippikkukayum pree-synaptic kanakshanukalude abhaavathil chaanal thurakkathe glude 2 nte ghadanayil maattangalkk kaaranamaakukayum cheiyunnu. cerebellin-1, neurexin-1β ennivayumaayi bandhippikkumbol glycine, dii-serin ennivaykku glud 2 ll chaanal thurakkaan kazhiyum. eee mattangal protein-protein edapedalukalil maattam varuthaan enn-terminal domaine vareyo sii-terminal domainileko signal nalkiyekkaam.
pathology.
grid 2-leeii heterosaigas illaathaakkal manushyaril attaxia, frontotemporal demensia, motor neuron edapedal ennivayodukoodiya sankeernamaaya spaastik paraplegiaykku kaaranamaakunnu, athesamayam oru homocygus biolelic illaathaakkal cerebellar attaaksiyayude oru syndrome, sradheyamaaya vikasana kaalathamasam, pyramid track edapedal, tonic upgase ennivayilekku nayikkunnu, ithu okkulomottar aprexia (ayoo) ulla attaaksiyaayi tharamthirikkaam, koodaathe ithine spinocerebeller attaxia, autosomal resussive type 18 (scarr 18) ennu vilikkunnu.
mouse grid 2 leeii oru pooyint mutation falamaayi chaanal function nettam, heterosaigas avasthayil prasavaananthara vikasana samayat cerebellar purkinje koshangalude selective, sell-autonomous apoptosis falamaayi attaxia, motor coordination kammi nayikkunna 'lourcher' enna phenotypeumaayi bandhappettirikkunnu. eee mutationulla homocygus elikal jananathinushesham taamasiyaathe bhrunajanana samayat midu-hind braine neuronukalude valia nashtam moolam marikkunnu.
ligandukal.
9-aminoacridine, 9-tetrahydroaminoacrine, 9-tetrahydroaminoacrine, enn1-dancil-spermin, pentamidin enniva δ2 adangiya resepterukalude athiraalikalaayi pravarthikkunnathaayi theliyikkappettittund.
ashayavinimayam.
grid 2, gopisi, grick 2, ptpn 4, gria 1 ennivayumaayi samvadikkunnathaayi theliyikkappettittund. grid 2 umm pree-bii lymphosite protein 3 (vipreb 3) umm thammilulla oru parasparabandham nirddeshikkappettittund, kaaranam manushyaril cerebellar purkinje neuronukalude uthbhavathil bii-lymphocytukalude vyakthamaaya praadhaanyam undu. undu elikalil nadatthiya roopashaasthraparamaaya padanangal soochippikkunnathu soochippikkunnathu lymphocytukalilum adrenal courtexilum undakamenkilum eee avakaashavaadangal sthireekarikkaan kooduthal padanangal nadathendathundu.

