
defelickfallin

korsuva enna brand naamatthil vilkkunna defelicfallin, mithamayathum kadinavumaaya chorichil chikilsikkaan upayogikkunna oru vedanasamhaariyaaya opioid peptaidaanu. ithu κ-opioid resepterinte (coor) peripherally specific, uyarnna selective agonistaayi pravartthikkunnu.
chila rogaprathirodha samvidaana koshangal prakadippikkunna peripheral naadi terminalukalilum korsilum coorse sajeevamaakkunnathiloode defelickfallin oru vedanasamhaarikayaayi pravartthikkunnu. peripheral naadi terminalukalil coorse sajeevamaakkunnath afferent naadi pravarthanatthinu kaaranamakunna ayoon chaanalukalude thadassathinu kaaranamaakukayum vedana signalukalude kaimaattam kuraykkukayum cheiyunnu, athesamayam rogaprathirodha samvidaana koshangal prakadippikkunna coorse sajeevamaakkunnath proinflammatory, naadi sensittaising mediatormaarude (udha.jii., prostaglandins).
2021 augustil amerikkayil medical upayogathinaayi defelicfallin amgeekarichu. yuu. ezz.ezz. phudu aandu drugg administration ithine phastt-inn-klaas marunnayi kanakkakkunnu.
samoohavum samskaaravum.
niyamaparamaaya padavi.
2022 februvari 24 nuu, europian medisins ejansiyude manushya upayogathinulla aushadha uthppannangalkkayulla samiti (chmp) oru nalla abhiprayam sweekarichu, vittumaaraatha vrukkarogavumaayi bandhapetta mithamayathum kadinavumaaya proorittas chikilsaykkaayi uddeshichittulla aushadha ulppannamaaya kaapruviyaykk oru vipanana amgeekaaram nalkaan shupaarsha cheythu. eee aushadha uthppannathinulla apekshakan viphore fresinius medical cair renal farma france aanu. 2022 eprilil europian yooniyanil medical upayogathinaayi defelicfallin amgeekarichu.
gaveshanam.
shasthrakriyaykk sheshamulla vedanayude chikilsaykkaayi oru intravinus ejantaayi kaaraa therapeutics ithu vikasippichukondirikku. oru ooral formulation vikasippichittund. peripheral selectivity kaaranam, defelickfaalinil sedation, dysphoria, pentasosin, phenasosin thudangiya muun coor-acting vedanasamhaarikal polulla kendra paarshwafalangal illa. vedanasamhaarikalkku purame, proorittas (chorichil) chikilsaykkaayi defelicfallin parisodhikkukayum cheiyunnu. defelickfallin shasthrakriyaykk sheshamulla vedanaykkulla randaam ghatta klinikkal pareekshanangal poortthiyaakkukayum surakshithavum nannayi sahikkaavunnathumaayirikkunnathum ganyavum "karuthutta" klinikkal falaprapti prakadippikkukayum cheythu. hemodialysis rogikalil euremic prooritasinaayi moonnaam ghatta klinikkal pareekshanavum ithu poortthiyaakki.

