vasopressin risapttar

vasopressin resepterukal ennu vilikkunna tissue-nirddishta jii protein-cuppled resepterukalude (gpcrs) uthejanathiloodeyaanu vaasopresinte pravartthanangal madhyasthatha vahikkunnath, avaye vii 1 (vii 1 eiii), vii 2, vii 3 (vii 1 bii) risapttar upavibhagangalaayi tharamthirickunnu. eee moonnu upavibhaagangalum praadeshikavalkkaranam, pravartthanam, signal transduction samvidaanangal ennivayil vyathyaasappettirikkunnu.
upavibhagangal.
vasopressin resepterinu moonnu upavibhaagangalund v1a (v1), v1b (v3), v2.
kaanapedunna risapttar.
vascular minusamarnna peshikalil uyarnna saandrathayil kaanapedunna kaanapedunna resepterukal resepterukal phosphattidail-inositol-bisphosphate cascade vazhi intra sellular kaalsyam vardhikkunnathiloode vaasokanstrikshan undaakkunnu. hridaya myosaittukalkkum kaanappedunnarr undu. koodaathe masthishkam, vrishanangal, mikacha servical ganglian, karal, rakthakkuzhalukal, vrukkasambandhamaaya medula ennivayil kaanappedunnarr sthithicheyyunnu.
kaanappedunnarr platelettukalil kaanapedunnu, ithu uthejippikkumbol intra sellular kaalsyatthinte vardhanavinu kaaranamaakukayum thrombosis sugamamakkukayum cheiyunnu. platelet kaanappedunnarinte polymorphism kaaranam saadhaarana manushya platelettukalude vaasopresinodulla aggregation prathikaranatthil ganyamaaya vaividhyamundenn padanangal soochippikkunnu.
vrukkayil kaanapedunna kaanappedunnarr, avaa medallery interstishyal cellukal, vaasa recta, shekharana naalatthinte epithelial cellukal ennivayil uyarnna saandrathayil kaanapedunnu. baahya medullayilekkulla rakthapravahathe baadhikkathe aantharika medullayilekkulla rakthayottam kuraykkunnathinu vasopressin kaanappedunnarr vazhi medullary vasculaturil pravartthikkunnu. shekharana naalatthinte luminal membranile kaanappedunnarreiiis vaasoprassinte antiduretic pravartthanatthe parimithappedutthunnu. koodaathe, vasopressin orupakshe kaanappedunnarr vazhi ozhukunna dhamanikale thiranjedutthu churukkunnu, pakshe afferent dhamanikaliloodeyalla.
dhamanikaliloodeyalla risapttar.
v2 risapttar (v2r) praadhamikamaayi n-linked glycosylation saadhyathayulla saittukalude ennathil v1r-ll ninnu vyathyasthamaan; v1r-nuu amino-terminasilum extra sellular looppilum sittukal undu, athesamayam v2r-nuu extra sellular amino-terminasil orotta saittund.
vaasoprassinte ariyappedunna antiduretic prabhavam sambhavikkunnath vii1aarr sajeevamaakkunnathiloodeyaanu. vrukka shekharana vaahikayude ausmotic jalathinte praveshanakshamatha vardhippichukondu vrukkayil ninnulla jala visarjjanathe vasopressin niyanthrikkunnu-camp sajeevamaakkunna gs signalling paathayumayi vii 2 aarr bandhippikkunnathiloode ithu vishadeekarikkunnu. vii1aarr samvedanakshamatha kuranjathinu pakaram β-arasttin aantharikamaakkiya sesham gs sajeevamaakkunnath thudarunnu. orotta vii1aarr, β-arasttin, heterotrimeric gs enniva ulkkollunna "mega-complexukal" roopappeduthaanulla resepterukalude kazhivaanu vii1aarr signalling cheiyunna eee aantharikamaakkiya gs vishadeekarikkunnathu. vrukkayile vardhicha intra sellular camp shekharikkunna daktt principal cellukalude appikkal plasma membranumaayi akwaporin-2 vahikkunna vesikkilukalude samyojanathinu kaaranamaakukayum jalathinte punarnirmmaanam vardhippikkukayum cheiyunnu.
manushyante risapttar.
manushyante manushyante risapttar risapttar, munbu kaanappedunnabaiiiaarr ennariyappettirunnu) oru jii-protein-cuppled pityoottari resepteraanu, athinte kuravu kaaranam, aduthide maathrame savisheshathayundaayirunnulla. savisheshathayundaayirunnulla 424-amino assid shreniyil yathaakramam 45 sathamaanam, 39 sathamaanam, 45 sathamaanam enniva kaanappedunnarr, vii1aarr, auxitosin risapttar (odr) ennivayumaayi saamyamullathaan. ennirunnaalum, ennirunnaalum oru pharmacological profile undu, athu manushyante kaanappedunnarill ninnu verthirikkukayum risapttar expressionte nilavaaratthe aashrayich vyathyastha jii-proteinukal vazhi niravadhi signalling pathakal sajeevamaakkukayum cheiyunnu.
pravartthanam.
eee moonnu proteinukalum jii-protein cuppled resepterukalaanenkilum (gpcrs), (gpcrs), avpr1eiii ennivayude sajeevamaakkal phospholipase siye uthejippikkunnu, athesamayam athesamayam nte sajeevamaakkal adenilate cyclasine uthejippikkunnu. vasopressinulla eee moonnu resepterukalkku savisheshamaaya tissue vitharanangalund. vascular smooth peshi koshangal, heppattosaittukal, platelettukal, mastishka koshangal, garbhashaya koshangal ennivayil eiii. vii. pii. aarr. 1eiii prakadippikkunnu. muun pityoottariyude koshangalilum thalachoriludaneelavum, prathyekichu hippocampal caa 2 feeldile pyramid neuronukalilum avpr 1 bii prakadippikkunnu. vrukka kuzhalukalil, pradhaanamaayum vidooramaaya churungiya kuzhalukalilum shekharikkunna naalangalilum, garbhapindatthinte shwaasakosha koshangalilum shwaasakosha arbudathilum eiii. vii. pii. aarr. 2 prakadippikkunnu, avasaanathe rund badal spliesingumaayi bandhappettirikkunnu. uthejam rakthapravaahathilekk kattapidikkunna vividha gadakangal purathuvidunna karalilum eiii. vii. pii. aarr. 2 prakadippikkunnu. vrukkayil, moothram kendreekarikkukayum jeevajalangalil jala homeostasis nilanirthukayum cheiyunna samvidaanangale uthejippichu arjinin vasopressinode prathikarikkuka ennathaanu avpr 2-nte praadhamika pravartthanam. eiii. vii. pii. aarr. 2-nte pravartthanam nashtappedumbol, nephrogenic diabetis insipidus (enn. dii. aii) rogam undaakunnu.
athiraalikal.
vasopressin resepterukale thadayunna marunnukalaanu vasopressin risapttar aantaagonistukal (vraas). anuchithamaya antiduritic hormon sraavam (siyad), conjesteevu hart failer (chf), sirosis ennivayude syndrome moolamundaakunna hyponetremia chikilsikkaan saadhaaranayaayi vraas upayogikkunnu.
somaattostaattin oru malsara inhibittaraanu. 
saadhaaranayaayi, draavakam athinte nischitha pooyintil ninnu thaazheyaakumbol, plasma vasopressin alavu kandethanaakaathe pookukayum aquaresis falamaavukayum cheiyunnu. siyaadil, hypotonity undaayirunnittum vasopressin release poornnamaayum adichamarthappedunnil. sirosisilum chfl, layippikkunna sthalangalilekku layani vitharanam cheiyunnathu thakararilaakukayo glomerular filtration nirakk kurayukayo cheiyunnathu paramavadhi jala-puranthallal sheshiyude vaikalyathin kaaranamaakunnu, athinte falamaayi vasopressin release sthiratha kaivarikkukayum ithu vellam nilanirthunnathilekku nayikkukayum cheiyunnu.
konivaapttan, tolvaapttan, mosavaapttan, lixivaptan, shaathavaapttan thudangiya puthiya tharam "vapttan marunnukal" vasopressin risapttar athiraalikalil ulppedunnu.

