
toom maniatis

toom maniatis (jananam meyy 8,1943), molecular aandu sellular bayolajiyude oru american professoraanu. columbia sarvakalaashaalayile professoraaya addeham newyork genome sentarinte scientific director ceoyum aayi sevanamanushtikkunnu.
vidyaabhyaasam.
maniatis bii labhichu.eiii. koodaathe emm.ezz. boulderile colorado sarvakalashaalayil ninnu birudavum vaandarbilt sarvakalashaalayil ninnu molecular biologyil phd nedi. harward sarvakalaashaalayilum englandile kembridjile medical research kaunsil (emrc) laborattari oof molecular biologyilum addeham poost doctoral patanam nadatthi.
gaveshanavum thozhilum.
jeane niyanthrana samvidaanangalekkurichulla padanatthil jeane cloning saankethikavidyakalum avayude prayogangalum maniatis vikasippikkukayum pracharippikkukayum cheythu.
cdna cloning.
harwardile biochemistry aandu molecular biology asisttant professor colled spring harber laborattari (chl) faakkaltti amgavumaayirikke, maniatis doow. fottis kafaattosum argiris effstratiadis messenture rnaude ("koppi" allengil cdna ennu vilikkunnu) poornna neelamulla eratta strended dna koppikal samanvayippikkunnathinum cloninginumulla oru reethi vikasippikkunnu. eee reethi manushya jeenukale verthirikkunnathilum sasthanikalude koshangalile "recombinent" proteinukalude ulppaadanathilum oru pradhana chuvaduveppu nalki, ithu biotechnology vyavasaayathile oru kendra prakriyayaan.
genomic dna librarikal.
pasadena kaaliforniyayile california instittyoott oof teknolajiyil biology vibhaagathil chernna maniatis, avide addehathinte laborattari vyakthigatha manushya jeenukale verthirichedukkunnathum padikkunnathinumulla reethikal vikasippichu. eee laab manushya genomile ellah jeenukalum ulkkollunna aadyathe manushya genomic dna library srishtichu.
genomic dna library upayogichu, maniatis laab manushya bii-globin jeenukalude muzhuvan "clusterineyum" verthirichedukkukayum savisheshatha nalkukayum cheythu, avaa kloon cheytha aadyathe manushya jeenukalaayirunnu, avayude dna sequenceukal nirnnayikkappettu. rna transcription, rna spliesing, jeane expression niyanthranam ennivayude samvidaanangalekkurichulla adisthaana ulkkazhchakal addehathinte laborattari sambhavana cheythu.
1980ll maniatis harwardylake madangiyethukayum avide padippikkukayum thante gaveshanam thudarukayum cheythu. 2010ll addeham columbia sarvakalaashaalayilekk maari. avidevechu 2010ll addeham newyork genome sentar sthaapichu. 2016ll addeham sentarinte scientific director ceoyum aayi.
molecular cloning maanuval.
molecular cloning maanuval" ezhuthunnathil maniatis ulppettirunnu. 1979ll maniatis laab jeane cloning reethikal vikasippikkukayum vinyasikkukayum cheythirunnu. colled spring harber laboratariyil jeane cloningle oru venalkkaala kozhs maniyattisum eddu fritshum padippichu. kozhsil avatharippicha ulladakkathinte adisthaanathil avar paatapusthakam ezhuthaan cslinte scientific director joseph saambrookkumaayi sahakarichu.
biotechnology kambanikal.
maniyattisum maarkk pataashneyum chernnu janithaka instittyoott, ink sthaapichu. 1980-ll haemophiliayude chikilsaykkaayi raktham kattapidikkunna gadakangalum anaemiyayude chikilsaykkaayi erythropoitin ulppede niravadhi fda amgeekritha marunnukal "protein biologics" kambani nirmmichu. eee kambaniye vaith farmaceuticals etteduthu.
1994-ll maniatis, fred goldberg, harward medical schoolil ninnulla mattullavar ennivar proscript sthaapichu. multiple mylomayude chikilsaykkaayi eph. dii. eiii amgeekaricha protesome inhibittar velcade (bortisomid) kambani kandupidichu. sahasraabdam/takeda faarmayaanu proscript svanthamaakkiyathu.
2004ll maniatis aaksilaron farma enna tii. jii. eph-bii kambaniyumaayi sahakarichu myodisplastic syndrome (emm. dii. ezz), bii-thalassemia ennivayude chikilsaykkaayi reblosil ulppedeyulla "ligand trap" marunnukal nirmmichu.
2006ll maniatis, chaals suukkar, richard axel ennivar chernnaanu calliope sthaapichathu. kudalile upapachayam, koshajwalana vaikalyangal enniva chikilsikkunnathinulla marunnukalude vikasanathil ithu shradha kendreekarichu.
1999ll biotechnology vaidyashaasthrathilum maniatis, david godel, vilyam rudder ennivarkku brandies yooniversitti jacob aandu luis gabe award labhichu.
sevanam.
colled spring harber laborattari, jaaksan laborattari, rockfeller yooniversitti ennivayude board oof trasttikalil maniatis sevanamanushtichittundu.
rogathe chikilsikkunnathinulla vaagdaanathode samyukthangalude klinikkal parisodhana thwarithappeduthunnathina nilavilulla marunnu kaandidettukalkkaayi nischayichittulla mungananakalumaayi marunnu kandethaline samyojippikkunna alse associationte samrambhamaya treat alsinu (translation research advancing therapy phoor alse) maniatis neethrthwam nalki. avichai cremer sthaapicha "prais phoor life" enna shaasthra upadeshaka samithiyilum addeham sevanamanushtichu. maniatis jacob eph nedi. alse associationil ninnulla alse gaveshanathil jaavitsinte life time acheevment award.
newyork genome sentarinte sahasthaapakanum athinte shaasthreeya steering kammittiyude thalavanumaaya maniatis 2011 ll sthaapithamaayathu muthal athinte director board amgamaayi sevanamanushtichittundu.
adisthaana, medical shaasthrangalude purogathikkaayi genomic saankethikavidyayude prayogathinaayi samarppichirikkunna yooniversitti wide columbia yooniversitti presition medisin inishyetteevinte (cpm) sthaapaka directoraan maniatis, ithu presition medisin parisheelanathilekku (manushyarogangal kandethunnathinum chikilsikkunnathinum janithaka, genomic vivarangalude upayogam) nayikkunnu.
avaardukal.
ethans sarvakalashaala, colled spring harber graajvett school oof biological sciences, rockfeller sarvakalashaala ennivayil ninnu maniatis oonarari phd birudangal nediyittundu.
maniatis yuu. esilekku thiranjedukkappettu.ezz. naashanal akkadami oof sciences, 1985ll american akkadami oof arts aandu sciences, yuu. ezz.ezz. 2012ll naashanal akkadami oof medisin.

