divyathvam

faava beansilum lathirus saattivasilum kaanapedunna alcaloidal gunangalulla oru ooksidantum bays aanu dvsin (2,6-diamino-4,500-dihydroxypyrimidine). ithu visainte oru aglaikon aanu. diasettett roopamaanu (2,6-diamino-1,6-dihydro-45-pyrimidiniyon) oru saadhaarana derivative.
sambhavam.
eshyayilum kizhakkan aafrikkayilum saadhaaranayaayi valarunna vilakuranjathum karuthuttathumaaya bhakshya srothassaaya khesaari ennum ariyappedunna fawa beansilum payarvargamaaya "lathirus saattivasilum" dvsin kaanapedunnu.
synthesis.
sasyangalil, nishkriyamaaya β-glucosidaya visaininte jalavishleshanathil ninnaan dvsin kurayunnathu.
krithrima daivasamshleshanathinulla lalithamaaya moonnu ghatta prakriya
prathikaranangal.
divisininte chila raasa savisheshathakal parishodhichittundu. ithu 2,6-dichlorophenolyndophenol, phosphomolibdate allengil phosphotangstettu ennivayude kshara laayanikale shakthamayi kuraykkukayum oru amoniacal ferric chloride layaniyumaayi prathikarikkumbol theevramaaya neela niram uthpaadippikkukayum cheiyunnuvennu ariyappedunnu, ithu oru enolic hydroxyl grouppinte saannidhyam thirichariyunnathinum theliyikkunnathinum upayogikkunnu.
ooksijan undengil dvsin valare asthiramaanu, kshara piechu thalatthil ooksideshan ettavum vegathilaanu. saadhaarana thapanilayilum neutral piechilum daivikathayude ardhaayuss ekadesham araa manikkooraan. rund samyukthangalum thilappikkunnathiloode udan thanne nasippikkappedunnu, koodaathe hevi mettal ayonukalude, prathyekichu kyu 2 + nte saannidhyam moolam saadhaarana avasthayile thakarcha thwarithappeduthaam.
vishaamsham.
dvsin fawa beensinte haemotoxic gadakamaayi kanakkaakkappedunnu, koodaathe glucose-6-phoosphett dehydrajanes dehydrajanes allengil allengil kuravu moolam broad beans upabhogathodulla haemolitic prathikaranam ulppedunna oru thakararaya favisathinte vikasanathil oru punk vahikkunnu. ex-linked resussive heridari rogamaaya eee kuravu lokamembaadumulla ettavum saadhaaranamaaya ensaiminte kuravaanu. aafrikkan, eshyan, medittareniyan, middle-eestten vamshajaraayavaril ithu prathyekichum saadhaaranamaanu. haemolysis, neenda manjappitham, kernicterous, theevramaaya kesukalil vrukkasambandhamaaya thakaraarukal enniva polum favisathinte lakshanangalil ulppedunnu.
hydrajan peroxide, superxide ayoon thudangiya reactive ooksijan enangale srishtikkunna chuvanna rakthaanukkalile ooksijanumaayi dvsin prathipravartthikkunnu. eee thanmathrakal nadfinteyum glutathayoninteyum sakthamaaya oksidaisarukalaanu. oksidaisarukalaanu kurravulla vyakthikalkk gloottathayon kurayunnathu thadayaan vendathra vegathil naduff punarujjeevippikkaan kazhiyilla. eee ksheenam aglaikkonukal moolamundaakunna auxidative sammarddathil ninnu koshangalkk samrakshanam labhikkaathathin kaaranamaakunnu. auxidative stress haemoglobin, disulfide boond aggregettukal (hains bodikal) ennivaykku kedupaadukal varuthukayum ithu haemolitic anaemiyaykku kaaranamaakukayum cheiyunnu, ithine favism ennu vilikkunnu.
eshyayileyum kizhakkan aafrikkayileyum varalchayum shaamavum neridunna pradeshangalil saadhaaranayaayi valarunna oru payarvargamaaya "lathirus saattivasi" nte vishapravarthanathinu dvsin undu, kuranjathu bhaagikamaayo utharavaadiyaanu, mattu vilakal valarunnathil paraajayappedumbol manushya upabhogathinum kannukalikalkkulla bhakshanathinumulla oru 'insurance vila' aayi, avayude aarogyaparamaya apakadangal ariyappedunnu.
mrugangalil swaadheenam.
elikalil nadatthiya inn vitro padanangal kaanikkunnath, chuvanna rakthaanukkalude suspensionilekku 1.5 millimeter haemotoxic doses cherkkumbol, sellular glutathayonil druthagathiyilulla kuravundaakunnathinum echinosaittukalude roopeekaranathinum membran asthikoodathinu kedupaadukal varuthunnathinum kaaranamaayi ennaanu. ithu hematokritt kurayaan kaaranamaayi.

