laurence koorii

gaveshanavum thozhilum.
thozhilum thudakkathil, nobel sammana jethaavaaya biochemistum faarmakkolajistumaaya doow. oru vairal-nirddishta ensaiminu thiranjedutthathum nirddishtavumaaya oru aantivairal oru vittumaaraatha vairal anubaadhaye (herpus simplexes vairas type 2 allengil echsv-2) niyantrikkaan surakshithamaayum falapradamaayum nalkaamennu theliyikkaan gertrude eliyon. 1980 num 1984 num idayil nadatthiya classic padanangalil asaiklovirinte topical, intravinus, ooral formulationukal upayogichu kvaanditteevu vairal looad reduction klinikkal benifittum thammilulla pradhana ashayangalum directed line association koorii aadyamaayi aavishkarichu. fdal ninnu druthagathiyilulla amgeekaaram labhicha aadyathe aanti vairal marunnaan asaiklovir, koodaathe koriyude padanangalaanu jananendria herpessil athinte upayogam nirvachichathu. eee padanangal dainamdina deerghakaala upayogathinaayi oru aantivairal aadyamaayi upayogikkunnathu ulppede echsv-1, echsv-2, verisella chickenpox vairas thudangiya vaividhyamaarnna anubaadhakalil asaiklovirinu licencylake nayichu. acyclovirum athinte derivetteevukalaaya valasiclovirum famsiclovirum lokathile ettavum kooduthal nirddeshikkappedunna aantivairalukalaan 400 dashalakshathiladhikam aalukalkk echu. ezz. vii-2 anubaadhayund. eee aadyakaala padanangal echuaivi, heppattaitis bii ennivaykku phalapradamaaya aantivairal therapy vikasippikkunnathin farmaceutical, medical sayans kammyoonittikalude thudarnnulla vijayakaramaya pankaalitthatthe prerippichu.
1987-ll, echuaivi-1-lake aantivairalukal pareekshikkunnathinayi sthaapithamaaya niha support aids klinikkal trials groupinu (actji) koorii nirddesham nalkukayum, maathru-bhroona echuaivi pakarunnath kuraykkunnathinu aanti retroviral marunninte upayogam theliyikkunna pradhana klinikkal pareekshanangal nadathukayum, echuaiviyil ninnu athijeevanam neendunirthunnathinu aanti retroviralukalude samyojanathinte upayogavum kaanikkukayum cheythu. eee samayat, aidukal vikasikkunnathin valare munbuthanne echuaivi plaasmayil sanjarichuvennu aaa laborattari theliyichu. echuaivi anubaadhayude lakshanangalillaatha ghattangalil aadyakaala chikitsa aarambhikkunnath aichuaiviyilekkulla purogathi kuraykkukayum echuaivi replication niyanthranathinum maanejmentinum aanti retroviralukalude (3> 2> 1 marunnu) samyojanam nirnaayakamaanennum actji pinneedu theliyichu; athinte phalam echuaivi niyanthranam aagolathalathil aayurdairkhyam vardhippikkaan praapthamakki ennathaanu. rund nucleosideukalum oru protees inhibittarumulla triple kompineshan therapy vairal looad ganyamaayi kuraykkunnu, sidi 4 + tii-sell ennathil vardhanavu, protees inhibittar cherthukondu aaktiveshan markerukal kuraykkunnu. klinikkal gaveshana pravarthanangalil community amgangalude samyojanathe aadyamaayi nayichathu actji aanu.
1990 kalude madhyathil, koorii vaxine vikasana mekhalayil thante pravarthanangalil kooduthal shradha kendreekarichu, 1998 ll us naashanal instittyoott oof allergy aandu panfective diseasumaayi chernnu echuaivi vaaksinukalude vikasanam vegathilaakkaan oru aagola klinikkal trials group vikasippichu. 2002ll, aagola echuaivi vaxine samrambham roopappeduthunnathil koorii pradhana chaalakashakthiyaayi. lokathile pradhana vyavasaayavalkkarikkappetta raajyangalile nethaakkal melnottam vahikkunna churukkam chila shaasthreeya paripaadikalil onnaanu eee samrambham.
kaposi sarcoma, burkit lymphoma thudangiya pakarchavyaadhiyumaayi bandhapetta arbudangalude chikilsaykkum prathirodhatthinumaayi mikacha therapy padikkukayum vikasippikkukayum cheyyuka ennathaanu koriyude pradhana shaasthreeya samrambhangalilonn. 2000-kalude madhyathil, koorii fred hutchinson cancer research sentarum ugaanda cancer instittyoottum thammilulla pankaalittham aarambhichu. 2010 juulai juulai doow. fred hutchinson cancer gaveshana kendratthinte naalaamathe presidentaayi koriye thiranjedutthu. fred hachinte vivarthana gaveshana paripaadikalude karuth vardhippikkuka, vikaswara raajyangalilekku kaansarinulla mikacha chikilsakalum prathirodhangalum konduvarunnathinulla prathibaddhatha ennivayaayirunnu addehathinte pradhana samrambhangalilonn. 2015 meyy maasathil, fred hutch/yusiai pankaalittham sub-saharan aafrikkayile njangalum aafrikkan sthaapanangalum samyukthamaayi nirmmicha aadyathe samagra cancer sentar thurakkunnathilekku nayichu yusi-fred hutch cancer sentar. 2013-ll, tii-sell immunology thante pravartthanatthinte oru valarchayayi, koorii kaansarinethire pooraadunnathinu janithaka enchiniyaring tii cellukal upayogikkunnathinu samarppichirikkunna juno therapeuticsinte sahasthaapakanaayi.
koriyude aadyakaala gaveshanam herpus simplexes vairasukale kaikaaryam cheyyukayum rogathe nirvachikkunna niravadhi supradhana padanangalkku neethrthwam nalkukayum acyclovirinteyum valasiclovirinteyum chikilsaykkaayi licensor nalkukayum cheythu. laingika pankaalikal thammilulla sanbarkkam kuraykkunnathinulla oru patanam ithil ulppedunnu. ulppedunnu 1988num idayil, echsv-2, echuaivi-1 ennivayumaayulla anubadha thammilulla bandham kaanikkunna pradhana padanangalude oru parambara koorii prasidheekarichu. eee padanangal echuaivi ettedukkalum vyaapanavum kuraykkunnathinu aanti-echsv-2 therapy pailat, valia vilppana klinikkal pareekshanangalilekku nayichu. 2000-ll, koorii echsv-2-naayi aantivairal therapy upayogichu aadyathe discordent jody patanam nadatthi. echsv-2-nte transmission kuraykkunnathinekkurillu 2004-leeii addehathinte prasidheekaranamaanu aantivairalukalkk mattullavarilekku anubaadhayude vyaapanam kuraykkaan kazhiyumennu aadyamaayi theliyichathu (prathirodhamaayi chikitsa), eee ashayam pinneedu echpdn 052 protocol team upayogichu, ithu discordent dambathikalilekku echuaivi pakarunnath kuraykkunnathinu thudarchayaaya kala upayogichu. rogaavasthayum echuaivi-aiyude vyaapanavum kuraykkunnathinulla pothujanaarogya sanbradaayangalude nilavile moolakkallukalilonnaanu eee randaamathe sameepanam.
aduthide, echsv reactivation niyanthrikkunnathil mucosal rogaprathirodha samvidaanathinte praadhaanyam addehathinte gaveshana samgham kaanichu, ithu jananendria herpus chikilsikkunnathinaayi puthiya waxinukal vikasippikkanulla sramathinu nilavile vegathayilekku nayichu. munbu, echu. ezz. vii-2 rogakaariyude shaasthreeya samavayam vairas veendum sajeevamaakunnath apoorvamaanennum ganglian thalatthile vairas-neuronal edapedalukal nirnnayikkunnuvennum mikka veendum sajeevamakunnathum jananendria shathangalkku kaaranamakumennum aayirunnu.
echuaivi vaxine vikasana mekhalayile oru kendra vyakthiyaan koorii. echuaivi vaxine trials network (echvdn) ippol 30 ladhikam nagarangalil vyaapichukidakkunna anchu bhookhandangalile anweshakar ulkkollunnu, koodaathe aagolathalathil echuaivi vaaksinukalude ghattam 1-3 klinikkal pareekshanangalkkaayulla gaveshanathinu neethrthwam nalkunnu. 2018 leeii kanakkanusarichu vadakke america, thekke america, sub-saharan aafrikkayile niravadhi rajyangal ennividangalil echvdn 4 valia thothilulla falaprapti pareekshanangal nadathunnu. 2015 desember 1 nuu echuaivi, aids enniva thadayaan saadhyathayulla oru vaxine pinthudarunna koorii, echttidivien shaasthranjarude pravartthanangal "kauntdaun tuu seero" enna thalakkettilulla oru echbio/vais special reportil eduthukaanichu."
bahumathikal.
nyoo englandu jenal oof medisin edittoriyal boardil amgamaayirunnu koorii. addeham american pakarchavyaadhi sosaitti oof amerikkayude fello american epidemiological sosaitti, american sosaitti phoor klinikkal investigation, association oof american physicians ennivayile amgavumaanu. koodaathe, paan american sosaittiyude klinikkal virology award, american sexuval traansmitted diseases associationte paran award, yooniversitti oof mishigan medical skoolinte vishishta poorvva vidyaarthi award ennivayum addehathinu labhichittund. 2008ll naashanal akkadami oof medisinil thiranjedukkappetta addeham 2012ll american akkadami oof arts aandu sciencesil amgamaayi thiranjedukkappettu. addeham 900-ladhikam shaasthreeya prasidheekaranangalum edittoriyalukalum prasidheekarichittundu (2018 leeii kanakkanusarichu).

