
lexicon farmaceuticals

lexicon farmaceuticals, ink. manushyarogangalkkulla chikilsakal vikasippikkunna oru biopharmaceutical kambaniyaanu ithu. 1995ll texasile vanapradeshangalil lexicon janithakashasthram enna peril sahasthaapakar professor alaan bradley professor bradleyude poost doctoral fello arther tii sands chernnaanu kambani sthaapichathu. kambani athinte pettant nediya mouse jeane nokkautt saankethikavidyayum vipulamaaya inn vivo screening kazhivukalum upayogichu athinte genome 5000 prograamil ekadesham 5,000 jeenukal padikkukayum nooriladhikam chikitsa lakshyangal thirichariyukayum cheythu. lexicon onniladhikam marunnu kaandidettukale manushya klinikkal pareekshanangalilekku vikasippikkukayum athinte klinikkal prograamukalkku pinnil vishalavum vaividhyapoornavumaaya marunnu lakshyangalund. oongoolaji, gastroentrology, immunology, metabolism, ofthalmology ennivayulppede anchu chikitsa mekhalakalil lexicon mayakkumarunnu lakshyangal pinthudarunnu.
kambaniyude klinikkal marunnu kaandidettukalil type 2 prameha chikilsaykkaayi sotagliflosin (elx 4211); irritable bowell syndrome, mattu dahananaala vaikalyangal ennivayude chikilsaykkaayi elx1033; carcinoid syndrome ennivayumaayi bandhapetta lakshanangalude chikilsaykkaayi telotristaatt ethyl (elx1032); rheumatoid aarthraitis polulla svayam rogaprathirodha rogangalude chikilsaykkaayi elx2931 enniva ulppedunnu.
kambaniyude charithram.
1995 septambaril bailer koleju oof medisinte biotech samrambhamaayaan lexicon farmaceuticals sthaapithamaayathu. biotech charithratthile ettavum valia prarambha pothu ofarukalilonnaaya (220 dasalaksham dollar) 2000 eprilil kambani parasyamaayi. 2001 juunil lexicon nyoojezhsiyile prinsettanilulla koylakkanthu korppareshan enna swakaarya udamasthathayilulla cheria kemikkal library synthesis kambani vaangi, athu kambaniyude cheria thanmathrayudeyum aushadha rasathanthrathinteyum shramangalude sthalamaayi maari. kambaniyude yadhaartha peru lexicon janithakashasthram incorporated aayirunnu, ennaal 2007 ll peru lexicon farmaceuticals, ink ennu maatti. mayakkumarunnu vikasanathil oru puthiya shradha prathifalippikkuka.
jeenukalude pravartthanam nirvachikkaan jeane nokkautt saankethikavidya upayogikkunnathil kambani thudakkathil shradha kendreekarichu. manushyarudeyum elikaludeyum genome krameekarikkanulla anthaaraashtra shramathil ninnu eee sramam poorttheekarikkukayum prayojanam nedukayum cheythu (manushya genome project kaanuka). udamasthathayilulla jeane trapping jeane targetting saankethikavidyakalum upayogichu, kambani janithakamattam varuthiya mouse bhroona stem cellukalude lokathile ettavum valia shekharam srishtichu, oomnibaank ennariyappedunnu, koodaathe ettavum mayakkumarunnu marunninte shareerashaasthraparavum perumattaparavumaaya pravartthanangal kandethunnathinayi oru valia thothilulla sastani nokkautt prograam sthaapichu. eee prograamil ninnu shekharicha vivarangal kambaniyude lexvision daattaabesil sambharichirikkunnu, athil padicha ekadesham 5,000 jeane nokkttukal adangiyirikkunnu. kaalakramena, lexicon oru genomics kambaniyil ninnu manushyarogathinulla vazhithirivaya chikilsakal kandethunnathilum vikasippikkunnathilum shradha kendreekaricha oru marunnu kandethal, vikasana kambaniyaayi parinamichu. klinikkal pareekshanangalude vividha ghattangalil nilavil onniladhikam marunnu kaandidettukal kambanikkundu.
2016ll deloit phaast 500 north america pattikayil kambanikku <aii. dii. 1> rank labhichu.
saankethikavidya.
orotta jeane nokktu thadassappedunnathinte falamaayundaakunna shaareerikavum perumattaparavumaaya phalangal kandethunnathinayi nokktu elikale srishtikkunnathinum padikkunnathinum pettant nediya jeane trapping jeane targetting saankethikavidyakalum lexicon upayogikkunnu. elikalkkum manushyarkkum idayil jeane pravartthanatthilum shareerashaasthrathilum adutha saamyam ullathinaal, manushya jeenukalil bhooribhaagathinum mouse genome ullathinaal, puthiya marunnukalude kandethalil nokktu mouse saankethikavidya oru sakthamaaya upakaranamaayi mariyirikkunnu.
mayakkumarunnu kandethalil lexiconinte saankethikavidyayude moolyam shaasthra jenal nechar oru munkaala vishakalanathil vivarichittundu. eee vishakalanathinte nigamanam, mikka kesukalilum, 2001-leeii ettavum kooduthal vittazhikkappedunna 100 marunnukalude chikitsa falavumaayi nokktu elikale shaareerika savisheshathakalo phenotypeukalo thaarathamyam cheyyumbol nerittulla parasparabandham undaayirunnu ennathaanu. nokktu mouse saankethikavidyayude athisayakaramaaya prayojanam 2007-ll physiology allengil medisinil doctormark nobel sammanam nalki amgeekarikkappettu. marrio kaapechi, martin evans, olivar smithees.
saadhookaricha lakshyangalkkayi cheria thanmatra marunnukal vikasippikkunnathil, lexicon "click kemistry" ennariyappedunna aushadha rasathanthram upayogikkunnu."doow. keey. 2001-leeii rasathanthrathinulla nobal sammanam labhicha baari sharpless, puthiya samyukthangalude drutha samanvayathinaayi shakthavum vishwasaneeyavumaaya eee upakaranangalude koottatthinu thudakkamittu. valare karuthuttathum alakkavunnathumaaya jaivapravarthanangal upayogichu nirmmicha optikkali shudhamaaya samyukthangalude vaividhyamaarnna librarikal srishtikkunnathinum kambaniye valia vaividhyathinte samyuktha shekharangal srishtikkunnathinum vividha chikitsa lakshya kudumbangale abhisambodhana cheiyunnathinaayi samyuktha shekharangal prathyekamaayi krameekarikkunnathinum lexicon solution-phase kemistry upayogikkunnu. manushyarogangalkkethire surakshithavum phalapradavumaanennu theliyikkapetta marunnukalude raasa gadanakal vishakalanam cheythum aaa arivu scarfoldukaludeyum raasa nirmmaana blokkukaludeyum roopakalppanayil upayogichu dhaaraalam puthiya marunnu polulla samyukthangalude uthpaadanathinaayi lexiconile aushadha rasathanthranjar eee librarikal roopakalppana cheiyunnu.
sthalangal.
texassilum newjezhsiyilum kaanapedunna rund sthalangalil ninnaan lexicon pravartthikkunnathu. hyoosttaninu vadakku texasile vanapradesangalilaanu korpparettu aasthaanam. kambaniyude marunnu lakshyangal kandethunnathinum saadhookarikkunnathinum preclinical gaveshanathil marunnu kaandidettukal parishodhikkunnathinumulla nighanduvinte praadhamika gaveshana kendramaayi eee sthalam pravartthikkunnu. kambaniyude klinikkal development aandu regulatory team korpparettu aasthaanathaanu.
nyoojezhsiyile prinsettanilulla lexiconinte campus lexiconinte cheria thanmatra aushadha rasathanthrathinteyum preclinical vikasana shramangaludeyum aasthaanamaanu. chikitsa vikasanathinaayi puthiya rasavasthukkal srishtikkunnathinulla nighanduvinte praadhamika aushadha rasatantra saittayi eee saitt pravartthikkunnu.

