
paiks5

manushyaril "paiks 5" jeane encode cheiyunna oru proteinaan paired boxes protein paiks-5.
pravartthanam.
transcription gadakangalude paired boxes (paiks) kudumbatthile amgamaanu paiks 5 jeane. eee jeane kudumbatthinte kendra savisheshatha jodiyakkiya boxes ennariyappedunna oru puthiyathum valare samrakshikkappettathumaya dna-binding domainanu. paiks proteinukal aadyakaala vikasanathile pradhana niyanthranangalaan, avayude jeenukalude aavishkaarathile mattangal neoplastic parivarthanatthinu kaaranamaakumenn karuthappedunnu. bii-sell vamshavali nirddishta aaktivettar proteine (bii. ezz. eiii. pii) paiks5 jeane encode cheiyunnu, athu bii-sell deferentiationte aadyaghattangalil prakadippikkappedunnu, pakshe avasana ghattangalilalla. cns vrishanavum vikasippikkunnathilum athinte aavishkaaram kandethiyittundu, athinaal, paiks 5 jeane uthppannam bii-sell deferentiationil mathramalla, neural vikasanathilum beejajananathilum pradhana punk vahichekkaam.
klinikkal praadhaanyam.
plasmacitoid upavibhaagathile cheria lymphocytic lymphomakalilum uruthirinja valia kosha lymphomakalilum aavarthikkunna tii (9; 14) (pii 13; kyu 32) translocationukalil ulppedunna 9pii13 chromosome mekhalayilaanu paiks 5 jeane sthithicheyyunnathu. eee translocation aii. jii. jiinn lokkasinte sakthamaaya iii-muu enhancerine paiks 5 promotermaarude aduthekku konduvarunnu, ithu paiks 5 jeane traanscriptionte niyanthranam illaathaakkunnathu eee lymphomakalude rogakaarikalkk kaaranamaakumenn soochippikkunnu.
hodgekins lymphoma express paiks-5-nte reed-sternberg koshangalude 97 sathamaanam vare.
ashayavinimayam.
paiks5 tii. iii. ell. iii. 4, maranavumaayi bandhapetta protein 6 ennivayumaayi prathipravarthikkunnathi theliyikkappettittund.

