
stercobilin

hemm kaattabolisatthinte oru anthima ulppannamaaya tetrapyrolic pittharasam pigmentaanu stercobilin. manushya malatthinte thavitt niratthinu kaaranamakunna rasavasthukkalaaya ithu 1932 ll malatthil ninnu verthirichedukkukayum cheythu. nadikalile malineekaranatthinte alavukal jeevarasaayanikamaayi thirichariyunnathinulla adayaalamaayi stercobilin (anubandha eurobilin) upayogikkaam.
metabolism.
erythrocytukalil kaanapedunna haemoglobinte hemomity thakarunnathinte falamaanu stercobilin. macrophageukal senesant erithrosaittukale thakarkkukayum heemine bilivardinaayi vibhajikkukayum cheiyunnu, ithu athivegam biliroobine swathanthramaakkunnu. bilirubin rakthapravaahathile plasma proteinukalumaayi (prathyekichu albumin) shakthamayi bandhippikkukayum karalilekku kondupookukayum cheiyunnu, avide onno rando glucuronic assid avashishtangalumayi bilirubin diglucuronidelake samyojippikkukayum cherukudalilekku pitthamaayi sravikkukayum cheiyunnu. cherukudalil, chila bilirubin glucuronide terminal iliyathile bacteria ensimeukal vazhi bilirubin aayi parivartthanam cheyyappedunnu. eee bilirubin niramillaatha eurobilinojan aayi parivartthanam cheyyappedunnu. vankudalil avasheshikkunna eurobilinojan onnukil stercobilinojan aayi kuraykkukayum oduvil stercobilin aayi ooksidais cheyyukayum cheyyaam, allengil ithu nerittu stercobilin aayi kuraykkaam. manushya malatthinte thavitt niratthinu kaaranamaakunnath stercobilin aanu. stercobilin pinneedu malam puranthallunnu.
rogathil punk.
thadassamaaya manjappitham.
obstructive manjappitham undaakumbol, oru bilirubin cherukudalil athunnilla, athaayath stercobilinojan roopappedunnilla. stercobilin, mattu pitharasa varnnangalude abhavam malam kalimannu niramakaan kaaranamaakunnu.
thavitt pigment pitthasanchi.
colalithiasis baadhicha rund shishukkalude vishakalanathil braun pigment pitthasanchil ganyamaaya alavil stercobilin undennu kandethi. pitthanaalatthile bacteria anubaadhakalaal budhimuttunna sisukkalil thavitt pigment pitthasanchi swamedhayaa roopappedumennu eee patanam soochippichu.
rogachikitsayil punk.
1996ll mcfee mattullavarum nadatthiya oru patanam. kuranja micromolar saandrathayil vitharanam cheyyumbol stercobilin, eurobilin, bilivardin, santobilirubic assid ennivayulppedeyulla mattu anubandha pyrolic pigmentukalkku echuaivi-1 protees inhibittarukalude oru puthiya klasai pravartthikkaan kazhiyumennu nirddeshichu. vijayakaramaya echuaivi-1 protees inhibittar merck ell-700,417 (enn, enn-biss (2-hydroxy-1-indanile)-2,6-diphenylmethyl-4-hydroxy-1,7-heptandiamide) enna aakruthiyilulla saamyam moolamaanu eee pigmentukal thiranjedutthathu. eee pigmentukalude aushadhashaasthraparamaaya falaprapti padikkaan kooduthal gaveshanam nirddeshikkappedunnu.

