
sii-sii kemokin risapttar type 7

manushyaril "sii. sii. aarr. 7" jeane encode cheiyunna oru proteinaan sii-sii kemokin risapttar type 7. eee resepterinaayi rund ligandukal thiricharinjittundu keemokkainukal (sii-sii motif) ligand 19 (sii. sii. ell. 19/ell. sii), (sii-sii motif) ligand 21 (sii. sii. ell. 21). ligandukalkku resepterumaayi samanamaaya aduppamundu, ennirunnaalum sii. sii. ell. 19 sii. sii. aarr. 7-nte aantharikavalkkaranathinum sii. sii. ell. 19/sii. sii. ell 21 signalukalilekkulla sellinte samvedanakshamatha kuraykkunnathinum prerippikkunnathaayi theliyikkappettittund. vividha signalling kaaskedukaliloode signal thaazhekku transdues cheiyunna heterotrimeric jii proteinukalumaayi jodiyakkiya 7 transmembran domainukalulla oru transmembran proteinaan sii. sii. aarr. 7. eee tissukal sravikkunna nirddishta kemokkainukal kandethunnathiloode rogaprathirodha koshangale rogaprathirodha avayavangalilekku (lymph nodukal, thymus, pleeha) nayikkuka ennathaanu resepterinte pradhana pravartthanam.
sii. sii. aarr. 7 aduthide sii. dii. 197 (klasttar oof deferentiation 197) aayi namakaranam cheyyappettittund.
pravartthanam.
eee jeane encode cheytha protein jii protein-cuppled risapttar kudumbatthile amgamaanu. eee resepterine epsteen-baar vairas (iii. bii. vii) prerippicha oru jeane aayi thiricharinju, ithu bii lymphocytukalile iii. bii. vii efakttukalude madhyasthanaanennu karuthappedunnu.<mukalil paranjathupole, prathirodhavum sahishnutayum vikasippikkunnathin aavashyamaaya lymph nodukal polulla rogaprathirodha avayavangalilekku risapttar rogaprathirodha koshangale nayikkunnu, ennaal thymasil tii cellukalude vikasanathinum ithu pradhaanamaan. risapttar kooduthalum prakadippikkunnathu adaptive rogaprathirodha kosha tharangalaaya thymocytukal, naivu tii, bii cellukal, regulatory tii cellukal, central memory lymphocyteukal, dendritik cellukal ennivayilaanu.<dendraitik sell pakwathaye uthejippikkunnathinu ref namam = "10.3389/fmolb.2022.834149"> </rep> ccr7 kaanichittundu. lymph nodukal, pleeha thudangiya vividha dvitheeya lymphoid avayavangalilekku tii cellukal hoaming cheiyunnathilum pleehaykkullil tii cellukalude kadathum sii. sii. aarr. 7 ulppedunnu.
dendraitik koshangalil ccr7.
dendraitik koshangalilanu ccr7s pravartthanam ettavum nannayi padikkunnathu. peripheral tissuevukalile avayude sajeevamaakkal koshatthinte uparithalathil ccr7 expressione prerippikkunnu, ithu lymph nodil ulppaadippikkunna ccl19, ccl21 enniva thirichariyukayum qoo-stimuleshan moleculukalude (b7) dendritik sell expression vardhippikkukayum cheiyunnu, koodaathe mhc klaas I allengil mhc klaas II.<riff neyim = "10.4049/jimmunol.174.7.4070"> <// ریف> ccr7 signalling chemotaxis, aaktin dynamics ennivaye baadikkunnathaayi kandethi, mathramalla dendritik koshangalude athijeevanatheyum badhikkunnu, ennirunnaalum paraamarshicha ellah pravartthanangalum vyathyastha swatantra signalling paathakalaanu.<riff namam = "" HTTPS:// Doi.oorgu/<aii. dii. 2> fimu. <aii. dii. 1>> chemotaxis niyanthrikkunnath mapec paathayaan, ithu aaktin dynamics niyanthrikkunna sii. sii. aarr. 7 signalling pathayil ninnu swathanthramaanu. eee kaaskedinte executive gadakangal kainaasukal meck 1/2, erc 1/2, pii38, jnk ennivayum orupakshe mattu gadakangalumaanu. executive kainaasukal phosphorilettu transcription gadakangalum mattu regulatorukalum athuvazhi koshatthinte ekspresan profile maattunnu. sii. sii. aarr. 7 bandhatthil sellular athijeevanam vardhikkunnathu protein uthejanathe prothsaahippikkunna protein prathirodhatthil ninnum protein prathirodhatthil ninnum undaakunnu, kaaranam risapttar paii3keey/ekedi/emm. tii. aarr paathaye sajeevamakkunnathaayi ariyappedunnu, eee paathayude ifakttar thanmathrakal emm. tii. aarr, enn. eph. keey. bii ennivayaanu, koottaayi aanti-apoptotic bii. sii. ell. 2 protein expression vazhiyum proo-apoptotic proteinukalaaya jii. ezz. keey3bii, foxo 1/3,4iii. bii. pii1 ennivayude nirodhanathiloodeyumaanu prabhavam cheluthunnathu. sii. sii. aarr. 7 rowa/coffilin paathayiloode sellular aaktin dynamicsine badhikkunnu.
kendra sahishnuthayil sii. sii. aarr. 7-nte swaadheenam.
thymasile tii cellukalude thiranjeduppu prakriyaykkum athinte roopaghadanaykkum sii. sii. aarr. 7 pradhaanamaanennu theliyikkappettittund. sii. sii. aarr. 7 illaatha elikalil vikasana samayat thymocytukal kuravaanennum kooduthal thavana svayam rogaprathirodha vaikalyangalundennum mouse modalukalile pareekshanangal theliyichittundu. lymphoid projenittarukale thymasilekku maattunnathilum thymic courtexil ninnu medullayilekkulla thymosite parivartthanatthilum sii. sii. aarr. 7 pankedukkunnuvennu vishwasikkappedunnu. eratta negatteevu thymosite (tii sell vikasanathinte aadya ghattam) positteev selectionu vidheyamaakumbol, athu eratta positteev aayi maarukayum (sidi 4, sidi 8 coursepterukal enniva prakadippikkukayum cheiyunnu) ccr 7 prakadippikkaan thudangukayum cheiyunnu, ithu negatteevu selection nadakkunna thymic medullayilekku nayikkunnu. "sii. sii. aarr. 7" nokktu elikalkku chorchayude negatteevu selection undu, avaa svayam rogaprathirodha vaikalyangalaan. eee samvidaanam thymus morphology thadassavum aparyapthamaaya tii sell risapttar stimuleshanum aanennu karuthappedunnu, ennirunnaalum sii. sii. aarr. 7 kendra sahishnuthaye mathramalla, tolerogenic dendritik koshangale lymph nodukalilekku anuvadikkunnathiloode peripheral sahishnutayeyum badhikkunnu ennathu sradhikkendathaanu.<riff namam = "10.3390/ijms22158340"> </riff>
klinikkal praadhaanyam.
cheruthallaatha shwaasakosha arbudam, gastric arbudam, annanaala arbudam thudangiya vividha arbuda koshangalaan sii. sii. aarr. 7 prakadippikkunnathu. saadhaaranayaayi sasyakudumba proteinukalulla sii. sii. aarr. 7-nte cancer koshangal prakadippikkunnathu metaastaasisumaayum pothuve mosham roganirnayavumaayum bandhappettirikkunnu. sii. sii. aarr. 7 expression cancer rogikalude roganirnayathe mattunna onniladhikam samvidaanangal kandethiyittundu.<riff namam = "10.1016/j.dendraitik koshangalude udaaharanathil mukalil vivarichathupole, sii. sii. aarr. 7 koshatthinte athijeevanam vardhippikkukayum sii. sii. ell. 19/sii. sii. ell. 21 gradiantine pinthudarnnu migrate cheyyaan praapthamaakkukayum cheiyunnu, ithu lymph nodukalilekku nayikkunnu, koodaathe sii. sii. aarr. 7 ligation koshangale verpeduthaanum migrate cheyyaanum anuvadikkunnathinaal metaastaasisinu crusial aaya emt traansishane prothsaahippikkunnave theliyikkappettittund. sii. sii. aarr. 7 signalling veju eph-sii, veju eph-dii thanmaathrakale prerippikkunnu, ithu tumourinu chuttum lymphonogenesis prothsaahippikkunnu.

