
faama 83echu

manushyaril faama83echu (savisheshathayillaatha protein faama83echu) ennariyappedunna oru proteine encode cheiyunna oru jeenaanu faama83echu. nucleusine lakshyamitulla faama83echu pallukalude inaamalinte gadanaaparamaaya vikasanathilum calcificationilum oru punk vahikkumennu pravachichu.
jeane.
sthalam.
143723933 ll aarambhich 143738030 ll avasaanikkunna chromosome 8 (8q24.3) nte neelamulla kaiyilaanu faama83h sthithicheyyunnathu. faama83h jeane 14097 bays jodikalil vyaapichukidakkukayum-strandle ooriyantad cheyyukayum cheiyunnu. 5, 604 adisthaana jodikalum 5 exonukalum chernnathaanu coding mekhala.
aavishkaaram.
manushyashareerathiludaneelam thaarathamyena kuranja alavil faama83echu sarvavyaapiyaayi prakadippikkappedunnu.
traanskript vakabhedangal.
manushyaril faama 83echu jeeninte ariyappedunna oru pradhana uthppannam maathrameyulloo.
homology.
peralukal.
faama 83echinte peraalogukalonnumilla
oorthologukal.
manushya kudumbatthinte 83h enna vividha oorthologukalude oru pattika chuvadeyundu. meshayil aduthum, udanadi, vidooramaayi bandhapetta oorthologukal ulppedunnu.
manushya protein faama 83echinte oorthologukal avarohana kramatthilo vyathichalana theeyathiyilo thudarnnu sathamaanam aidantittiyude aarohana kramatthilo mukalil pattikappedutthiyirikku. ellah oorthologukalilum udaneelam faama83echu valare samrakshikkappedunnu, ithu ettavum kuranja samanamaaya oorthooloogil 40 sathamaanam aidantittiyode pradarshippikkunnu. kaalakramena faama 83echu saavadhaanathilum thulyamaayum vikasichu.
protein.
pothuvaaya swathukkal.
faama 83echinte tanmatra bharam <aii. dii. 1> aanu, athil 1179 amino aasidukal adangiyirikkunnu. aiso electric pooyint 6.52 aanu. proteinil kaaryamaaya positteev allengil negatteevu charge clusterukalonnumilla. 254-275 ll ninnu 210-kaludeyum 420-444.1 ll ninnu 240-kaludeyum oru stretch undu. 
rachana.
faama83echu prolin sambushtamaanu, 10.32% protein aanu, koodaathe 1.1% maathram varunna asparajin kuravaanu. oro amino aasidinteyum sathamaanam ghadana proteente oorthologukaliludaneelam valare sthirathayullathaanu. ettavum vidooramaaya orthologue amino assid gadanayile ettavum vyathyasam pradarshippikkunnu.
domainukal.
faama83echinu ariyappedunna rund domainukalundu. pldc _ fam83h (phospholipase polulla domaine) domaine fam83h-ll 17-281 muthal neelunnu. ithinu pravartthanaparamaayi pradhanappetta histidin illa, athinaal ithinu samanamaaya ghadana pankidaamenkilum ithinu pld pravartthanam illa. mipp-tii3 microtuble binding domaine 909-1176 muthal neelunnu.
vivarthanaananthara mattangal.
valare phosphorylated poost modificationaanu faama83echu. pravachikkapetta 11 phosphorylated saittukalund. poost translation modification sumoilation saittukalude uyarnna saadhyathayulla rund motifukalundu. nuclear-cytosolic gathagatham, transcriptional niyanthranam, protein sthiratha ennivayulppede niravadhi sellular prakriyakalil sumoilation sittukal ulppedunnu. efam83echinu signal pepttaid illa
dvitheeya ghadana.
praadhamikamaayi alfa helisukalum kramarahithamaya koyilukalum chernnathaanu faama83echu. proteininte bhooribhaagavum alfa helikkukalilaanu. 231-252 ll ninnu oru transmembran domaine undu.
subsellular localisation.
protein faama83echu nucleusine lakshyamidunnu.
parasparaprathikarana proteinukal.
efam83echu doubludr72, mmp20 ennivayumaayi samvadikkunnathaayi kandethi. mmp20 extra sellular maatriksinte thakarchaykku kaaranamaakukayum ameloblaastukalile tissue punarnirmmaanatthil oru punk vahikkukayum cheiyunnu. doubludr72 leeii mutationukal amalogenesis apoornnathayil oru punk vahikkumennu karuthappedunnu.
klinikkal praadhaanyam.
disease association.
amalogenesis apoornnatha baadhicha aalukalkk faama 83h ll pravartthanam nashtappettu.