
zbtb32

sink viralum bii. tii. bii domaine adangiya protein 32 umm manushyaril 1960 bipi isadbitibi 32 jeane encode cheiyunna oru proteinaan. 52 keey. dii. eiii protein (487 aaa) oru transcriptional repressoraanu, jeane sajeevamaakumbol tii, bii koshangalil prakadippikkunnu, mathramalla vrishana koshangalilum ithu prakadamaanu. ithu poxvirusukalileyum sink-finger (poses), crupel (poock) protein kudumbatthileyum amgamaanu, koodaathe rogaprathirodha kosha tumerigenesis allengil rogaprathirodha kosha vikasanam ulppedunna onniladhikam screenukalil ithu thiricharinjittundu.
jeane aakttiveshane baadhikkunnathinaayi protein kromaattinilekku histoon modification ensaimukale niyamikkunnu. zbtb32 athinte taargett jeenukalilekku n-coor, hdac polulla corpressorukale recruit cheiyunnu, adichamarthal kromaattin avasthakale prerippikkukayum mattu proteinukalumaayi sahakarichu pravartthikkukayum cheiyunnu, udha.jii. jeenukalude transcription adichamarthaan blimp-1 upayogichu.
ithil oru enn-terminal bii. tii. bii/poses domaine (aii. pii. aarr. 000210) allengil oru eskipi1/bii. tii. bii/poses domaine (aii. pii. aarr. 011333), moonnu sii-terminal sink viralukal, znf _ c2h2 _ sf enniva adangiyirikkunnu. (ipr036236), znf _ c2h2 _ type domaine (ipr013087), oru znf _ ring/fyve/Phd domaine (ipr013083), thudarnnu oru oohaathmaka ubz4 domaine.
namakaranam.
sink viralum bii. tii. bii domaine adangiya protein 32 umm ariyappedunnu
ashayavinimayam.
zbtb32 ithumaayi edapedunnathaayi kaanichittundu
rogaprathirodha samvidaanam.
Zbtb32-nte aavishkaaram koshajwalana cytokainukalaal prachodippikkappedukayum swaabhaavika kolayali koshangalude vyaapanathe prolsaahippikkukayum cheiyunnu.
sthithivivarakkanakkukali vyathyasam vyathyasthamallengilum, zbtb32 nokkautt elikal type 1 prameham vikasippikkanulla pravanatha kaanikkunnu. koodaathe, mattu jeenukalil ninnulla nashtapariharam kaaranam, lymphosite vyaapanathil zbtb32 oru vyathyasavum kanikkunnilla.
kyaansar.
beejakosha stem cellukalilum hematopoyattik stem, projenittar cellukalilum defused large bii-sell lymphoma (dii. ell. bii. sii. ell) ennivayilum isadbitibi32 valareyadhikam prakadippikkukayum sietta jeenine nishabdamaakkunnathiloode rogaprathirodha samvidaanathe adichamarthunnathaayi kaanappedukayum cheiyunnu.
sthana tumourukalil transcription factor jeane "gaatta 3" maarunnu. sink-viral kaimuttumaayi bandhapetta proline domaine protein 2 (isadpio2) "gaatta 3" expression pravartthanavum niyanthrikkumbol, isadbitibi32 "gaatta 3" promotere lakshyamidunnathinu sahayikkunnu, ithu aakramanathmaka sthanaarbudangalude vikasanathinu kaaranamaakunnu.
deferential methylated jeenukal thammilulla methylation paraspara bandhathe adisthaanamaakkiyaanu dna methylation korileshan network nirmmichathu. candidate biomarkerukalude athijeevana vishakalanam nadatthi. thiricharinja ettu biomarkerukalil onnu, hubb jeenukal
vankudal canceril "zbtb32" aanu.
sysplatine sanbarkkam pularthiyathinu sesham zbtb32-nte padaprayogam niyanthrikkappedunnu.