nedd9

neural precursor sell developmentally daun-regulated protein 9 (nedu-9) manushyaril "nedu 9" jeane encode cheiyunna oru proteinaan. nedu-9 philamenteshan 1 (ef 1), crk-anubandha substrate-anubandha protein (kaas-ell), kaas scarfolding protein famili memper 2 (kaas 2) ennivayude enhancer ennum ariyappedunnu. eee jeeninte oru pradhana paralog bcar1 aanu.
kandethal.
1992ll kumar, "thudangiyavar., pradhaanamaayum bhroonathinte thalachoril prakadippikkunna oru koottam jeenukalude cloningine adisthaanamaakkiyulla nedu 9 3 'vivarthanam cheyyaatha pradeshavumaayi bandhapetta oru sequence tagg aadyam vivarichu, pakshe muthirnna elikale allah, neural precursor sell ennu peritta oru koottam jeenukal prakadippikkukayum vikasanaparamayi niyanthrikkukayum cheythu. 1996ll rund grouppukal swathanthramaayi nedu dii 9 jeeninte poornna kramam vivarikkukayum nedu dii 9 proteininte prarambha pravartthana vishakalanam nalkukayum cheythu. niyamam "thudangiyava."oru manushya cdna library" kall amithamaayi prakadippichu. serivisiya, koshachakratheyum kosha dhruveekarana niyanthranangaleyum oresamayam badhikkunna jeenukalkkaayi screen cheyyukayum oru philamentus yeest budding phenotype prerippikkukayum angane heff 1 proteine (philamenteshan 1 nte manushya vardhippikkunnayal) thirichariyukayum cheythu. eee patanam patanam neey phokkal addition kainaasinte (efeke) oru samvedanaathmaka pankaliyaayi thiricharinju, ithu integrin signalingumaayi bandhippikkunnu. prathyekam, maingishi "thudangiyava."tii cellukalile β1-integrins bandhippichathinethudarnna hyperphosphorylated protein encoding cheiyunna jeenine kloon cheyyukayum tii sell coastimulation prakriyayil oru punk vahikkumennu anumaanikkukayum cheythu, eee jeenine cases-ell (crk-anubandha substrateumaayi bandhapetta protein, lymphosite tharam) ennu nirddeshikkunnu.
jeane.
vardhippichu jeeninte genomic kordinettukal <aii. dii. 2>, <aii. dii. 3>, gratch 37 asambliyile 580, allengil gratch 38 asambliyile <aii. dii. 2>, <aii. dii. 1>, 328 ennivayaanu. jeane mainus strandilaanu. human genome oorganaiseshan (hugo) jeane nomenclature kammitti (echgnc) vikasippicha naamakaranatthe adisthaanamaakkiyulla cytogenetic sthaanam sthaanam 24 aanu. echgnc amgeekritha chihnamaanu bandhappettirikkunnu. 7733 (echgnc), 4739 (entress jeane), ensji 00000111859 (ensemble) ennivayaanu audyogika aidikal. kaas-ell, castle, heff 1, dj49g10.2, dj761i2.1, kaas 2, kaas 2 enniva aparanama chinnangalaanu. reases kurangukal, naaykkal, pashukkal, elikal, elikal, kozhikal, seabrafish, thavalakal ennivayil neddy 9 jeane samrakshikkappedunnu. kasherukkalil, ithu 4-jeane kudumbatthile amgamaanu, koodaathe bii. sii. aarr. 1 1, iii. eph. ezz (siin), kaas 4 (hep. ell) ennariyappedunna mattu samana jeenukalum undu.
vardhippichu promoterinu 2 transcriptional staartt saittukalund. traanskript veriyantukalaaya nm_006403.3, nm_001142393.1 enniva vyathyasthamaaya enn-terminiyulla proteinukal encode cheiyunnu (yathaakramam mkyk, mwtr). mousil, rund badal aadya exonukal mkik, mwar ennivayaanu. avarude pravartthanam ariyilla. nm_006403.3-maayi thaarathamyappeduthumbol nm _ 001142393 oru upstream lokkeshanil vivarthanam aarambikkunnu, ennaal rund traanskriptukalkkum 7 exonukalundu. kaanathaaya exonukalulla hrasvamaaya traanscriptukal allengil badal 3 'terminal exon vividha padanangalil kandethiyittundu; ennirunnaalum, koshatthile avayude punk vyakthamalla.
vardhippichu promoterinte 5 'mekhala ool-trans retinoic assid (aatra) aanu niyanthrikkunnath, koodaathe retinoid ex risapttar (rxr)/retinoic assid risapttar (rr) heterodymer kondu prathyekamaayi bandhippichirikkunna oru retinoic assid prathikarana ghadakam (apoorva) adangiyirikkunnu. aaril hydrocarbon risapttar (ehr) vazhiyulla niyanthranathe adisthaanamaakki paristhithi malineekarana dioxine aanu neddy 9 nuu kaaranamaakunnath. suff bii 1 qoo-repressorinte bandhathe adisthaanamaakki eestrajan nedu dii 9 adichamarthunnathaayi oru patanam kandethi. promoter mekhalayile tii-sell factor (tii. sii. eph) gadakangalumaayi bandhippikkunnathine adisthaanamaakki vankudal cancerile dablyu. enn. tii signalling vazhiyaan enn. iii. dii. dii prachodippikkunnathu. hypoxia-induced factor (echief) transcription gadakangale nedu 9 promoterumaayi bandhippikkunnathine adisthaanamaakki hypoxy vllinte nashtavum enididy 9 nuu kaaranamaakunnu. prostaglandin iii2 vardhippichu transcriptione prerippikkunnu. phoox transcription factor forkhead boxes boxes sii1, (foxi1) transcription factor enniva vardhippichu transcriptione prerippikkunnathaayi report cheyyappettittund. tii. jii. eph-beetta nedu. dii. 9 transcription prerippikkunnu. kramatthinte parisodhanayude adisthaanathil, adisthaanathil, enf-kappa bii ennivayulppede niravadhi adhika transcription gadakangalkku saadhyathayulla binding saittukalum vardhippichu promoterinu undu.
metteeriyal mirr-145-leeii 2-8 sthaanangalumaayi poruthappedunnathaanu uthejakangal 3 'uthru. mirr-145 lokkasile lokkasile pradeshangal meer-145-nte genomic mekhalayumaayi vardhippichu 3' uthru nerittu bandhippikkaan anuvadikkum, chila padanangal soochippikkunnathu eee mirr glioblastoma prostettu cancerilum vrukkasambandhamaaya kosha arbuda koshangalilum koshangalilum niyanthrikkunnu ennaanu. nedu 9 exon 1 muthal exon 4 vare 10 keey. bii. vare vyaapichukidakkunna bii 2 ennu perulla oru noonn-coding aarr. enn. eiii. vivarichittundenkilum eee enn. sii. aarr. enn. eyude pravarthanaparamaaya punk ithuvare vyakthamalla. bhroona thalachorilum bhroonathileyum muthirnna jeevajalangalileyum niravadhi koshangalilum vardhippichu valareyadhikam prakadippikkunnu. uyarnna aavishkaaram kaansarumaayi bandhappettirikkunnu, chuvade charcha cheythathupole.
protein kudumbam.
kasherukkalil 4 amgangalulla kaas (sii. aarr. keey-anubandha substrate) protein kudumbatthile amgamaanu nedu. dii. 9. mattu samaanaroopathilulla jeenukal bcar1 (p130cas), efs (sin), cas4 (hepl) ennivayaanu. bacteria, yeest allengil "sii" ennivayil kandethaavunna kandethaavunna jeane illa. elegans ". dii" yill orotta kudumbangam maathrame ulloo. melanogaster, "dcas ennu vilikkunnu.
ghadana.
manushyaril, 834 amino aasidukal neelamullathaanu vardhippichu. onniladhikam signal transduction pathakalil ulppedunna proteinukalkkaayi docking sittukal adangiyirikkunna oru noonn kaattalitik scarfolding proteinaan neddy 9, sell signalling kaaskedukalude vyapthiyum dairkhyavum niyanthrikkunnu, neddy 9-nte mothatthilulla ghadana chithram 1-ll graafikkaayi prathinidheekarikkunnu. 
eee domainukalil iva ulppedunnu
vivarthanaananthara parishkkaranangalude kaaryatthil, valarchaa saahacharyangale adisthaanamaakki vardhippichu ganyamaaya phosphorylation vidheyamaan. ettavum sajeevamaayi valarunna anusaranamulla koshangalil, 115,105 keey. dii. eiii. yude erattiyaayi nedu. dii. 9 maarunnu. serin/thrionin hyper-phosphorylated lakshyam vardhippichu neddy9 ghatta koshangalil kooduthalaayi kaanapedunnu, eee parishkkaranangal centrosome, maittotik spindle ennivayilekkulla vardhicha praadeshikavalkkaranavumaayi bandhappettirikkunnave soochippikkunnu. oru patanam soochippikkunnathu phosphatase phosphatase cytoskelital niyanthranatthiloode koshangalude verthiriv vazhi vazhi pii115-neey parivartthanam cheiyunnathu sajeevamaan, ennirunnaalum mattu padanangal parasparavirudhamaaya phalangal kandethiyittundu.
samanvayavum apachayavum.
koshachakrathiludaneelam nedd9 kaanapedunnu, ennaal g2/m ghatta koshangalil ithu kooduthalaayi kaanapedunnu. enn. iii. dii. dii. 9 caspace pilarppinum protesomalile apachayathinum vidheyamaan. koshangalude verpiriyalinte avasthakalil, prathyekichu anoikis allengil apoptosisinte prarambha ghattangalil, oru dii. ell. vii. dii saittil (avashishtam 363) kaaspesukal 3 allengil/allengil 7 upayogichu nedu. dii 9 athivegam pilarunnu, koodaathe oru dii. dii. aii. dii saittil (avashishtam 630) enn-terminal 55 keey. dii. eiii, sii-terminal 28 keey. dii. eiii sakalangal roopappedunnu. phokkal addition roopeekaranam vazhi eee villal thadayunnu, ithu marria addition avasthakalude sensaraayi nedd9 soochippikkunnu. koshangalile koshangalile amithamaya aavishkaaram sellular roundinginum verpiriyalinum kaaranamaakunnu, koodaathe apoptosisine prerippikkunnu, orupakshe phokkal aditionukalil athijeevanathe prothsaahippikkunna signalling complexukalil prabalamaaya-negatteevu prabhavam kaaranam. eee daatta orumichu soochippikkunnathu vyathyastha bandhappettirikkunnu poost translation parishkkaranangalude uthpaadanam sell dii/attaachment vazhi niyanthrikkappedunnu, ithu bandhappettirikkunnu vittuvarav niyantrikkaanum vyathyastha sellular prakriyakalil pankaalittham nadatthaanum anuvadikkunnu.
uthejakangal protesomalile apachayathinulla praadhamika lakshyam lakshyam aanu. tgf-beetta signalling ulppede niravadhi uthejakangal uthejakangal protesomalile apachayathinu kaaranamaakunnu. tii. jii. eph. betta resepterinte oru ifakttaraaya smad 3, eiii. pii. sii subunit eiii. pii. sii 10-maayi nerittu edapedukayum angane eiii. pii. sii complexine recruit cheyyukayum cheyyum. eiii. pii. sii complexinte sii. dii. echu. 1 subunit nedu. dii. 9 thirichariyukayum sarvvyaapithvavum thudarnnulla nedu. dii. 9-nte apachayavum niyanthrikkukayum cheiyunnu. maittotik purogathiye pinthunaykkunna orora-eiii upayogichu pravartthanangal poortthiyaakkiyathinethur maittosisinte avasaanathil protessov nedu. dii. 9-neey tharamthaazhthunnu.
tissue vitharanavum intra sellular localisation.
interface cellukalil, enn. iii. dii. dii. 9-nte bhooribhaagavum phokkal aditionukalilekku praadeshikavalkkarikkuppadu. ennirunnaalum, chila proteinukal cytoplasmic aanu, cheria kulangal centrosome, siliyayude basel body ennivayil praadeshikavalkkarikkuppadu. maittotik entriyil vardhippichu maittotik spindle vazhi neengunnu, oduvil cytokinesisile midu bodiyil praadeshikavalkkarikkuppadu.
pravartthanam.
sellular prakriyakalaaya vyaapanam, athijeevanam, migration, mattullava ennivaykku prasakthamaaya niravadhi pradhana signalling paathakalile oru intermediattaanu (valathuvashathulla chithram kaanuka).
integrin, phaak/raaftke, src kainaasukal.
koshangalude chalanam, extra sellular matricks (ecm), athijeevanam ennivayumaayi vyaapikkunnathum ottikkunnathum niyanthrikkunna integrin signalling, nedu 9-nulla ettavum mikacha signalling paathayaan. integrinukal phokkal aditionukale nucleate cheiyunna transmembrane proteinukalaanu, ecm, aaktin cytoskelittan ennivaykkidayil dvi-dishasoochana nalkunna gadanakalaanu. enn. iii. dii. dii formation sthirappeduthukayum phokkal aditionukalude vittuvarav niyanthrikkukayum cheiyunnu, ithu kosha chalanathe swaadheenikkukayum cancer koshangalude aakramanatheyum metaastaasisineyum swaadheenikkukayum cheiyunnu. integrin aaktiveshan prathikaranamaayi, phack allengil anubandha kinace raaftkukal oru phokkal addition saittilekk nedd9 neey recruit cheiyunnu, athine n-terminal shhaa3 domaine vazhi bandhippikkukayum phosphorylateukal nedd9 src-binding saittine bandhippikkukayum cheiyunnu. ithu src allengil src famili kainesine athinte athu domaine vazhi bandhappettirikkunnu bandhippikkaan anuvadikkunnu. src mattu kainesukalum upayogichu vardhippichu substrate domaininte phosphorylation, crkinum mattu adapterukalkkumaayi binding sittukal srishtikkunnathinu kaaranamaakunnu, athu athu binding motifukalumaayi bandhappettirikkunnu. doock 1, doock 3 doock 180, sii 3 jii thudangiya nucleotide exchange faaktarukal (gef) recruit cheiyunnathiloode enididy 9 crk complexukal roow, raas famili jidipesukale sajeevamaakkunnu.
eee jidipesukal koshangalude chalanathmakatha, vyaapanam enniva niyanthrikkukayum tumourinte purogathikkum aakramanathinum kaaranamaakukayum cheiyunnu. pala kosha tharangalilum, vardhippichu overexpression vyaapanavum krasent morphology (uyarnna chalanakshamathayude soochakam) vardhippikkunnu. ennirunnaalum, fibroblastukalil, neddy 9-nte abhavam kooduthal druthagathiyilulla phokkal addition vittuvaravilekku nayikkunnuvennu chila padanangal kandethiyittundu, ithu vanyamaaya tharavumayi thaarathamyappeduthumbol neddy 9-/-ll kudiyettam vardhippikkaan kaaranamaayi.
kyaansar koshangalil, jeff doock 3 upayogichu raaku 1 jidipesum tharamgavum sajeevamaakkunnathiloode messenkymal-type chalanam nadatthaan nedu dii 9 nuu kazhiyum, ithu jidipes roow, amoeboid chalanagal thadayunnu. emm. emm. pii. 14, emm. emm. pii. 2, emm. emm. pii. 9 metaloproteenesukal sajeevamaakkunnathiloode iii. sii. emm proteolysis nadathunnu.
kemokin resepterukal, tcr, bcr/abl, phine, elke kainaasukal.
kemokin-induced tii sell migration, tii sell risapttar (tcr)-mediated integrin aaktiveshan ennivayil bandhappettirikkunnu ulppedunnu. lymphocytukalil, integrin allengil tcr signalling tyrosine kainaasukal phine, elke (src famili kainaasukal) enniva vazhi neddy 9 phosphorylation prerippikkunnu, ithu tii sell migration athyaavasyamaanu. koodaathe, keymokin signalukalodu prathikarikkunnathin, eiii. bii. ell famili kainaasukal enn. iii. dii. dii phosphorylating vazhi jii. tii. pays ithu aaktiveshan prothsaahippikkunnu; enn. ezz. pii protein kudumbatthile amgamaaya transducer protein protein. ezz. ezz enn. iii. dii. dii sahakarikkunnu, ithu ithu aaktiveshan, sell migration, addition ennivaye kooduthal pinthunaykkunnu. bii koshangalil, koshangalil yumayullah bandhappettirikkunnu bandham bii sell risapttar (bcr) bandhathe thudarnnu integrin-mediated vardhippichu serin/thrionin hyperphosphorylation vardhippikkukayum bii lymphosite addition, chalanathmakatha, pleehayude naamamaatra mekhalakalilekku hoaming enniva prolsaahippikkukayum cheiyunnu. 
eestrajan risapttar. nedu dii 9 interactorukal interactorukal, ensp protein ensp 2/bii. sii. aarr 3 enniva aanti eestrajan prathirodhatthilum stanarbuda purogathiyilum ulppedunnu, eestrajanodulla sellular prathikaranatthil nedu dii 9 nuu oru punk chila daatta soochippikkunnu, ithil eestrajan virudha prathirodhatthilekkulla purogathi, sthanaarbudathinte purogathi, akramanam enniva ulppedunnu. 
artks (egfr). signalukal downstream risapttar tyrosine kainaasukal (aartikal) transduction cheiyunnathinum bandhappettirikkunnu sambhavana cheiyunnu. epidermal groth factor resepterum (iii. jii. eph. aarr) integrinukalum thammilulla crosstack signalling cheiyunnathil enn. iii. dii. dii 9-nuu cheriyathallaattha shwaasakosha arbudathil (enn. ezz. ell. sii) oru punk sthaapikkappettu. iii. jii. eph. aarinte nirodhanam enn. iii. jii. dii. 9-nte tyrosine phosphorilation kuraykkunnuvennu kaanichu. enn. iii. dii. dii 9 iii. jii. eph. aarr ifakttar protein ezz. sii. yumayi nerittu edapedukayum iii. jii. eph. aarinu prasakthamaaya downstream signalingine baadikkukayum cheiyunnu; elikalkku enn. iii. dii. dii 9 illaathathinaal iii. jii. eph. aarr. iii. aarr. keey. tii ennivayude pravartthanam kurayunnu. ensp proteinukal multidomain scarfoldukalaanu, ithu extra sellular stimulikalodu prathikarikkunnathin sajeevamaaya aartiekale bandhippikkukayum aartiekalkkum integrinukalkkum idayil signalling samyojippikkaan sahaayikkunnathin neddy 9, bcr 1 ennivaye recruit cheyyukayum cheiyunnu. kooduthal patanam aavashyamaanenkilum pii. dii. jii. efum mattu aarr. tii. keyukalum chernnu enn. iii. dii. dii sajeevamaakkiyittund.
tii. jii. eph-beetta.
tissue punarnirmmaanatthinteyum vikasanathil epithelial-messenkymal transition (emt)reyum oru niyanthranamaan tgf-beetta, koodaathe canceril metaastaasis prothsaahippikkunnu. niravadhi padanangal amt prothsaahippikkunnathi athyanthaapekshithamaaya tgf-beetta signalling paathayile oru downstream ifakttaraayi neddy 9 thiricharinjittundu. emm. sii. eph-7 koshangalil, epithelial protein iii-caderinte aavishkaarathe negatteevu aayi niyanthrikkunna nedu. dii. 9, iii-caderine kosha stharavumayi bandhappedunnathu thadayukayum ezz. aarr. sii-kinez sajeevamaakkukayum cheiyunnu. sajeevamaaya src iii-caderine aantharikavalkkaranavum lysosomal degradation nalkunnu. eee kandethalukalumayi poruthappedunna oru patanam, emm. sii. eph-10 koshangalile nedu. dii. 9 amithamaya aavishkaarathin marupadiyaayi epithelial maarkkarukalude (iii-caderine, okludin, β-catenin) niyanthranavum messenkymal maarkkarukalude (enn-caderine, vimentin, fibronectin) ekakaala niyanthranavumaan.
arora-eiii.
centrosomile orora-oru maittotik kainesumaayi nerittu bandhippikkunna bandhappettirikkunnu athinte pravartthanam prolsaahippikkukayum koshangale mitosisilekku praveshikkaan anuvadikkukayum cheiyunnu. maittosisinte avasaanathil neddy 9-nte apachayangal samayabandhithamaya orora-oru apachayathinu kaaranamaakunnu. nedu 9 amithamaayi prakadippikkunna koshangal multy pollar maittotik spindles asaadhaaranamaaya centrosomukalum adinjukoodunnathinu kaaranamakunna aparyapthamaaya cytochinesis prakadippikkunnu. maruvashathu, kaalaharanapetta vardhippichu ulla koshangalkk akaalathil centrosomukal verthirikkappedukayum maittosis samayat microtuble oorganaising pravartthanatthil kuravundaakukayum cheiyunnu, ithu kuthaka allengil asamamaya spindilsinte samrudhiyilekku nayikkukayum koshangale mitosisilekku praveshikkunnathil ninnu thadayukayum cheiyunnu. aadyakaala jii 1 samayat koshangal silia punarnirmmikkunnathil siliyayude adisthaana shareerathil orora-oru sajeevamakkalum neddy 9 niyanthrikkunnu. headjehog, poolisistin thudangiya proteinukalude nirbandhitha pravartthana sthalamaaya anubandha koshangalude uparithalathil ninnu neendunilkkunna cheria oorganellukalaanu silia siliyari sthirathaye swaadheenikkunnathiloode, eee signalling samvidaanangale badhikkaan neddy 9 sthaapichirikkunnu. arora kainesumaayi nedu 9-nte prathipravartthanavum tumour aakramanathil oru punk vahichekkaam. oru orora kinace (oorkka)/echu. dii. eiii. sii 6-ashrita reethiyil courtactin (sii. tii. tii. enn) yude asattileshan nedu. dii. 9 bandhippikkukayum niyanthrikkukayum cheiyunnu. vardhippichu allengil oorkkayude noock daun asattailetted sii. tii. tii. enn. yude alavil vardhanavinum sii. tii. tii. enn.-neey eph-aaktin bandhikkunnathil kurravinum kaaranamaakunnu. sii. tii. tii. enn.-nte desettileshan mimmicking mimmicking myoottantinte amithamaya aavishkaaram tumour koshangalude migration praaveenyavum munvashath aaktin dynamics punasthaapikkaan paryaapthamaan. sthanaarbudathinte senographt modalukalile alicertib, tubastin eiii enniva vazhi oorkka, echdack 6 pravartthanangal thadayunnathu pulmonary mettaastesukalude ennathil kuravundaakki.
klinikkal praadhaanyam.
nedu 9 nte homocygus ksheenam ulla transgenic elikal supradhanavum phalabhooyishtavumaanu, pakshe rogaprathirodha asaadhaaranathakalundu, ithu jeevithathil pinneedu marakamaaya avasthakalkku kaaranamaakunnu, vaikalyangal thudakkathil sookshumamaanu, pakshe pilkkala jeevithathil vardhikkunnu; plehayilekku bii sell hoaming, lymphosite kadathu enniva kuravaanu.
alshaimezhs rogam.
oru intronic mekhalayil sthithi cheiyunna vardhippichu neddy9 snp, vaiki aarambikkunna alsheimer rogavumaayi (looad) saadhyamaaya bandhathekkurichu padichu. ennirunnaalum, 2012-ll, wang "thudangiyava., oru mettaa vishakalanam nadathukayum uracha nigamanagalil ethaan kooduthal padanangal aavasyamaanennu nigamanam cheyyukayum cheythu. eee snp prasakthamaaya signalling kooduthal poornnamaayi charcha cheyyappedunnu.
kyaansar.
enn. iii. dii. dii-nte maattam varuthiya (saadhaaranayaayi uyarnna) aavishkaaram kaansarumaayi shakthamayi bandhappettirikkunnu. bandhappettirikkunnu apoorvvamaayi maathrame parivartthanam cheyyappedunnulloovenkum rogaprathirodha koshangalude pravartthanam, cancer ennivayulppedeyulla rogalakshanaavasthakalil palappozhum maattam varuthiya expression allengil phosphorylation (vardhicha pravartthanavumaayi bandhapetta) kaanikkunnu. NEDD9 overexpression sambhavikkunnathayi rekhappeduthiyittundu, chila sandarbhangalil ithu niravadhi vyathyastha maarakathakalude tumergenesis prakriyayumaayi bandhappettirikkunnu. mukalil charcha cheytha sthanaarbudathile udaaharanangalkk purame, vankudal, pancreatic, thalayum kazhuthum, andashayam, gastric, shwaasakosham, jananendria (prostettu ulppede), karal, vrukka arbudam, dahananaalathile stromal tumours, glioblastoma, neuroblastoma enniva eee maarakaavasthakalil ulppedunnu.
mattoru rogam.
strockil ninnu karakayarunnathin nedd9 expression pradhaanamaayirikkaam. elikalil shanikamaaya aagola ischemiaykku sesham cerebral courtexinteyum hippocampasinteyum neuronukalil neddy 9 niyanthrikkappedunnu. induced vardhippichu tyrosine phosphorylated aanu, ithu neuronukalude dendraittilum somayilum faakkumaayi bandhippichirikkunnu, koodaathe neurait valarchaye prolsaahippikkukayum cerebral ischemiaykku sesham neurological pravartthanam veendedukkunnathinu sambhavana cheyyukayum cheiyunnu. autosomal dominant poolisistik kidney disease (eiii. dii. pii. keey. dii) rogakaarikalil nedu. dii. 9 aduthide ulppettittund. manushya autosomal dominant poolisistik kidney diseasilum (eiii. dii. pii. keey. dii) mouse eiii. dii. pii. keey. dii modalukalilum enn. dii. dii. 9 expression uyarnnathaan, koodaathe enn. dii. dii 9 illaatha elikal saadhaarana enn. dii. dii 9 ullavarekkaal eiii. dii. pii. keey. diyude kooduthal kadinamaaya roopam vikasippichu.
chikitsa saadhyathakal.
cancerile athinte punk kaaranam, niravadhi padanangal oru chikitsa lakshyamo chikitsa maarganirddeshamo aayi NEDD9-nte saadhyathayulla moolyathe pariganichittundu. kinace domaine allengil eathenkilum nirvachikkapetta kaattalatik domaine illaathathinaal, ithu poornnamaayum intra sellular aayathinal, enididy 9 targettucheyyaan prayaasamulla oru thanmathrayaanu. 
cancer vikasanathil pradhana punk vahikkunna mattu signalling proteinukalkku oru scarfolding thanmaathrayaayi vardhippichu pravarthikkunnathinaal, mettaastaasisine pinthunaykkunnathil vardhippichu ovareksprashante phalangal sidhaanthathil athinte thaazhekkulla lakshyangal thadayunnathiloode laghookarikkaanaakum. oru padanatthil, mmtv-nyoo mammery tumourukalile neddy 9 illaathaakkunnathu faakkinteyum srcyudeyum inhibittiyarukalodulla avayude samvedanakshamatha vardhippichu. vardhippichu depletion breast tumour sell lainukale arora enna inhibittar alisertibilekku sensittais cheiyunnu. chikitsa prathikaranatthinulla oru biomarkeraayi enn. iii. dii. dii 9 pariganikkunnath oru prateeksha nalkunna gaveshana dishayaanu.
ashayavinimayam.
NEDD9 ithumaayi samvadikkunnathaayi kaanichittundu

