
disorasol

soranchiyam cellulosum enna bacteria samshleshicha disorasol enna chaakrika polycatide 1994-ll aadyamaayi kandethukayum verthirichedukkukayum cheythu. athinte raasaghadanayil oru macrocyclic valayavum rund oksaasol valayangalum adangiyirikkunnu. disoresol eiii fungus virudha pravartthanangal prakadippikkunnuvennu theliyikkappettilettum ithu yeesttinethire sajeevamaayirunnilla. koodaathe, tubulin asambliyude samvidaanathe thadassappeduthukayum microtubilukalude thadassathinu kaaranamaakukayum cheythukondu eee padaartham asaadhaaranamaamvidham kuranja picomolar thalatthil sakthamaaya cancer virudha swabhaavasavisheshathakal prakadippikkunnu. thalphalamaayi, eee prathyaaghaathangal sell apoptosisinte thudakkathilekku nayikkunnu. ennirunnaalum, valare uyarnna cytotoxisityum asthirathayum kaaranam disorasolukal klinikkil nerittu marunnukalaayi upayogikkaan kazhiyilla. athinaal, disorasolinte prakrithivirudhamaaya derivateevukal samanvayippikkunnathinaana raasa, biosynthetic synthesis pathakal roopakalppana cheythirikkunnathu, cancer virudha shakti kuraykkaathe athinte cytotoxisity kuraykkaamenna pratheekshayilaan.
jaivasamshleshanam.
disorasolinte jaivasamshleshanathinu sambhavana nalkunna naalu synthetic jeenukalaaya "diss" abcd thirichariyukayum rekhappeduthukayum cheythittundu. disabk jeenukal hibrid trans-attu type polycatide synthase (pii. keey. ezz) mega ensaimukale encode cheiyunnu, athesamayam dissed jeane oru adhika asail transferase protein anoilreductase (iii. aarr) encode cheiyunnu. prathyekichu, "diss" dii jeenil encode cheytha iii. aarr. disorasolinte jaivasamshleshana pathayil ulppettirunnilla.
saadhaaranayaayi, 10 synthetic moduleukal disorasolinte jaivasamshleshana pathayil ulppettirunnu. disoresol biss-laakton korinte pakuthiyude roopeekaranathil ezhu malonyl-qoo thanmaathrakalum oru serin thanmathra ekstendar unitukalaayi upayogikkunnu. thudarnnu, module 10-ll sthithicheyyunna theosterase (tii) domainil rund polycatide monomerukalude dimerisation allengil cyclisation nadakkunnu, ithu disorasolinte samanvayathilekku nayikkunnu. koodaathe, anthima uthppannathinte release module 8,9,10 enniva sugamamakkunnu. disorasolinte biosynthesis paathayile pii. keey. ezz monomer dimerisation prakriya paarambaryethara swabhaavam prakadippikkunnu.

