
tedisolid

tedisolid (munbu torrisolid, vyaapaaranaamam sivekstro), oru oksaasolidinon klaas antibioticaanu. sajeeva samyukthamaaya tedisolidinte oru phoosphett esttar prodragaanu tedisolid phoosphett. trius therapeutics (uthbhavam dong-eiii farmaceuticals) etteduthathinethudarnnu kyoobist farmaceuticals vikasippichedutha ithu, acute baakteeriyal charmmathinteyum charmma gadanayudeyum anubaadhakalude (sankeernamaaya charmma, charmma ghadana anubadhakal (sii. ezz. ezz. sii) ennum ariyappedunnu) chikilsaykkaayi vipananam cheiyunnu.
ookkaanam (asukham thonnal), thalavedana, vayarilakkam, chharddi ennivayaanu ettavum saadhaaranamaaya paarshwafalangal. eee paarshwafalangal saadhaaranayaayi mithamaayatho mithamaayatho aaya theevrathayulavayaayirunnu.
2014 juunil amerikkayil vaidyashaasthraparamaaya upayogathinum 2015 maarchil europian yooniyanil vaidyashaasthraparamaaya upayogathinum tedisolid amgeekarichu.
medical upayogangal.
tedisolidinu yuu amgeekaaram nalki.staphylococcus ooriyas" (methisilin-resistant strainukal, mrsa, methisilin-susseptible strainukal ennivayulppede), vividha "streptococcus" speesheesukal ("kall") ennivayulppede chila bakteeriyakal moolamundaakunna acute baakteeriyal charmma, charmma ghadana anubadhakal (absisi) chikilsaykkulla soochanayode 2014 juun 20 nuu phudu aandu drugg administration (fda). piyojanees, "s. agalaaktiya "," aandu "s. s' ulppedeyulla 'anginosus' group. anginosus, "s. idanilakkaar, "umm" umm. konstellaattas), enterococcus fecalis. linesolidine apekshichu staafailokokki, entarokokki ennivaykkethire 4 muthal 16 madangu vare sakthamaaya randaamathe thalamura ooksaasolidinoon derivative aanu tedisolid. chikilsaykkaayi shupaarsha cheiyunna alavu 200 milligram aanu, motham aarr divasathekku, vaayiloodeyo (bhakshanathodoppamo allaatheyo) allengil oru intravinus kuthivayppiloodeyo (rogikk 18 vayassinu mukalilaanenkil).
europian yooniyanil muthirnnavaril acute baakteeriyal charmma, charmma ghadana anubadhakal (absi) ennivayude chikilsaykkaayi tedisolid soochippikkunnu.
pravartthana samvidaanam.
tedisolid phoosphett (tii. aarr-701) ennathu plasma allengil kudal phosphataseukal upayogichu tedisolidilekku (tii. aarr-700) sajeevamaakkunna oru prodragaanu. sajeevamaayikkazhinjaal, bacteriayude 50-kalile ribosomal subunitumaayi (sweekarthaavinte saittil) bandhippichu protein synthesis thadayunnathiloode tedisolid athinte baakteeriyostaattik microbial pravartthanam nadathunnu.
klinikkal pareekshanangal.
tedisolid athinte linesolid allathathaayi rund ghattam-III pareekshanangalil theliyichu, ithu establish trialukal ennariyappedunnu.
puthiya federal niyamaprakaaram ippol antibiotic prothsaahanangal srishtikkunna (geyin aakt ennariyappedunnu) fda amgeekaricha randaamathe chikilsayaanu tedisolid. eee puthiya niyamaprakaaram nirmmikkunna puthiya antibioticukal oru yogyathayulla pakarchavyaadhi ulppannamaayi (qidp) roopakalppana cheyyum, ithu efda vegathilulla avalokanavum anchu varshathe adhika vipani exclusivy anuvadikkunnu.
prathikoola phalangal.
klinikkal pareekshanangalil kandethiya ettavum saadhaaranamaaya prathikoola phalangal ookkaanam, thalavedana, vayarilakkam, chharddi, thalakarakkam ennivayaayirunnu. 6 divasathil kooduthal dosukalkku vidheyamaaya vishayangal hematological paaraamettarukalil saadhyamaaya dose dairkhyavum kaanikkunna onnaam ghatta padanangalil kaanichirikkunnathupole tedisolidinu hematological (raktham) efakttukal undennu kandethiyittundu. velutha rakthaanukkalude alavu kuranja rogikalil ithinte suraksha sthaapichittilla. oksaasolidinon classile mattu amgangalkku samaanamaayi tedisolid rogikalkkum peripheral, opttik neuropathy ennivaykkulla saadhyatha kuravaanu.