
aii. aii. eph 6

integrin beetta 4 binding protein (itgb 4bipi) ennum ariyappedunna eucariotic translation inishyeshan factor 6 (ief 6) oru manushya jeenaanu.
basel lamina intermediat philament cytoskelittanumaayi bandhippikkunna gadanakalaanu hemidesmosomukal. hemidesmosomukalude oru pradhana pravartthana gadakamaanu integrin beetta-4 subunit (itgb 4), rund fibronectin tharam III domainukal adangiya oru protein. eee jeane encode cheytha protein aii. tii. jii. bii. 4-nte fibronectin tharam III domainukalumaayi bandhippikkukayum iii. tii. jii. bii. 4-neey intermediat philament cytoskelittanumaayi bandhippikkaan sahayikkukayum cheyyum. nucleusilum cytoplaasathilum layikkathathum kaanapedunnathumaaya encode cheytha proteinu oru vivarthana prarambha gadakamaayi pravartthikkaanum 40,60 ribosomal sabyoonittukalude bandhathe uthejippikkaanum jidipiyumaayi bandhippichirikkunna if 5-noppam pravartthikkaanum kazhiyum. eee jeeninaayi niravadhi vyathyastha isophomukal encode cheiyunna onniladhikam traanskript vakabhedangal kandethiyittundu.
eucariotic 80-kalile ribosome roopeekaranam, koshangalude valarcha, jeane expression ennivayil aii. aii. eph. 6 pradhana punk vahikkunnu. 40-kalum 60-kalum upaghadakangalaayi verthirikkaan kazhiyunna 80-kalile ribosome. pakwathayulla 60-kalile sabyoonittine samrakshikkaan EIF6 sahayikkunnu, thudarnnu EIF6 60-kalile subunitumaayi verpeduthanam, angane 40-kalile subunitumaayi bandhippichu ribosome roopappeduthaan kazhiyum. eee. aii. eph. 6-nte santhulithaavastha nilanirthendathu sareerathinu athyaavasyamaanu kurachu eee. aii. eph. 6 saadhaarana ribosominte samanvayathe sahayikkunnu, athesamayam valia alavil eee. aii. eph. 6 thadayunna 60-kall upaghadakangal 40-kall upaghadakangalumaayi bandhippikkunnu.
pravartthanam.
nucleolasilum cytoplaasathilum eee. aii. eph. 6 nilavilundu. eucariotic nucleolasil, 60-kalile pree-ribosomal complexes 40-kalile pree-ribosomal complexes verthirikkunna oru pree-ribosomal complexes, pakwathayulla ribosominte samanvayathil ulppedunnu. 60-kalile subunit biogenesisil aii. aii. eph. 6 anivaaryamaan, koodaathe aii. aii. eph. 6 illaathaakkunnathu marakamaaya falamundaakkunnu. aii. aii. eph. 6-nte bhagikamaaya neekkam cheiyunnathu free 60-kalile ribosomal subunit kurayunnathinu kaaranamaakunnu, athaayath ithu 40-kalile/60-kalile subunit anupaathathe baalansil ninnu thaazhthukayum protein sinthasisinte vegatha parimithappedutthukayum cheiyunnu. nucleolasil ninnu cytoplasathilekku eee. aii. eph. 6 shuttle bandhapetta 60-kalile pree-ribosomal complexes, thudarnnu 60-kalkk munbullavayumaayi eee. aii. eph. 6 verpeduthukayum angane 60-kalkk sheshamulla sabyoonittin 40-kalile subunitumaayi bandhippikkanum thudarnnulla purogathi thudaraanum kazhiyum. nirakk parimithappedutthunna vivarthana prarambha gadakamaayi pravartthikkaan iii. aii. eph. 6 nuu kazhiyum, koodaathe athinte padaprayoga nilakal vivarthana nirakkine swaadheenikkunnu. aii. aii. eph. 6-ll chilath protein vivarthanathe cheruthaayi thwarithappeduthum, athesamayam aii. aii. eph. 6-ll valia alavil ribosominte ulppaadanam thadayunnathiloode vivarthana prakriya thadassappeduthum. emrnaude translation niyanthranatthiloode glycolysis, phaatti assid synthesis ennivaykkum eif6-nte pravartthanam kaaranamaakunnu.
ghadana.
245 amino aasidukalaanu eee. aii. eph. 6-nuu neelam.
aavishkaaram.
vyathyastha tissuekalilum koshangalilum vyathyastha thalatthilulla aavishkaaramaanu aii. aii. eph. 6-nuu ullathu. stem cellukalilum saikling cellukalilum uyarnna thothilulla expression eee. aii. eph. 6-nuu undu, athesamayam ithu postmittottik cellukalil illa; thalachorilum epitheeliyayilum uyarnna thoth, peshikalil kuranja thoth.
ashayavinimayam.
efl2, itgb4, gnb2ell1 ennivayumaayi ief6 edapedunnathaayi thelinjittundu.
80-kalile ribosome roopeekaranam, koshangalude valarcha, jeane expression ennivayil aii. aii. eph. 6 pradhana punk vahikkunnu.
parinamam.
yeesttilum manushyarilum eef6 kaanapedunnu, athinte amino assid shreni iva randum thammil 77 sathamaanam samaanamaan. eee. aii. eph. 6-nte pakarppukaloo proteinullil samrakshicha rooparekhakalo polum ariyilla.
charithram.
1980 kalude thudakkathil linda ell enna sthaapanathil ninnulla jolikalaanu aii. aii. eph. 6 pravartthanatthe aadyamaayi vivarichathu. spremully umadas maithrayudeyum laborattarikal. 1997ll thangalude kruthikal prasidheekaricha maithrayudeyum jeane carlo maarchisiyoyudeyum grouppukal oduvil eee jeenine kloon cheythu.

