
pii7sii3

neuroprotective, proneurogenic efakttukal ullathum alsheimer rogathinum samanamaaya neuro degenerative disordezhsinum chikilsaykku upayogapradamaakunnathumaaya latreperdinumaayi (dimebone) bandhapetta oru marunnaan pii7sii3 (pool 7, samyuktham 3). pii7sii3 "inn vitro" yude aushadhashaasthraparamaaya phalangal fibroblast valarchaa ghadakam 1 (efgf-1) polulla endogenous proneurogenic peptaidukalumaayi saamyamullathaan, koodaathe pii7sii3-yude proneurogenic pravartthanam elikalodu thaarathamyam cheyyumbol latreperdinekkaal muppath madangu kooduthalaayirunnu. uyarnna ooral bioavilabilidyum deerghakaala pravartthanavum polulla anukoolamaaya pharmacokinetic gadakangalude adisthaanathil kooduthal mruga padanangalkkaayi pii7sii3 thiranjedutthu, ennaal mattu niravadhi anubandha samyukthangal samanamaaya pravartthanam kaanichu, athaayath kooduthal sakthamaaya fluorinated analog pii7sii3eiii20 veendum pathuvattam shakthamaan, koodaathe methoxy analog pii7sii3-oom, ithinaayi ("aarr") enantiomer sajeeva roopamaanennu nirnnayichu.
nicotinamide nicotinamide adenine daine nucleotidaayi (naad) parivartthanam cheiyunnathinu utharavaadiyaaya nirakk parimithappedutthunna ensaimaaya nicotinamide phosphoribosil transferase (naampt) sajeevamaakkunnath pii 7 sii 3 seerees samyukthangalude pravartthana samvidaanathil ulppedunnu. naampt sajeevamaakkunnathiloode, pii7sii3 samyukthangal naadinte intra sellular alavil vardhanavinu kaaranamaakunnu.