
enn-alfa-asattail transferase 10

manushyaril "naa 10" jeane encode cheythirikkunna oru ensime sabyoonittaan naatta kaattalitik subunit naa 10 ennum arast-thakaraarulla protein 1 homologue eiii (aard 1 eiii) ennum ariyappedunna enn-alfa-asattail transferase 10 (naa 10).
athinte sahaaya subunit Naa15-noppam, Naa10 ennathu naatta (nα-asattail transferase eiii) complexes aanu, ithu asattail-koyil ninnu chila proteinukalude enn-terminal primery amino groupilekku oru asattail grouppinte kaimaattatthe prathyekamaayi uthejippikkunnu. uyarnna yookkaariyottukalil, substrate specificiatyilum subunit ghadanayilum vyathyasamulla mattu 5 enn-asattail transferase (naatt) complexukal, naattb-naattf, vivarichittundu.
jean traanscriptukalum.
xq28 enna chromosomil sthithi cheiyunna manushya "Naa10" ll 8 exonukalum, 2 encoding, ithara splisingil ninnu uruthirinja moonnu vyathyastha isophomukalum adangiyirikkunnu. koodaathe, niravadhi manushya kosharekhakalil prakadippikkunna oru prosess cheytha "Naa10" jeane duplication "Naa11" ("ard2") thiricharinjittundu; ennirunnaalum, pinneedulla padanangal soochippikkunnathu Naa11 manushya kosharekhakalaya helah, heck293 allengil cancer tissuekalil prakadippikkunnilla, koodaathe "Naa11" traanscriptukal vrishana, plaasantal tissuekalil maathrame kandethiyulloo. pradhaanamaayum vrishanangalil prakadippikkunna eliyilum Naa11 kandethiyittundu. "naa11" manushyanil <aii. dii. 1> chromosomilum mousil 5 iii. 3 chromosomilum sthithicheyyunnu, athil rund exonukal maathrame adangiyittulloo. elikalkku mattoru naa 10 polulla paralog undu, naa 12. naa 12 nuu naatt pravartthanamundu, koodaathe naa 10 nte nashtatthinu janithakamaayi nashtapariharam nalkunnu, athesamayam naa 10/naa 12 nall ennathu maikkil bhroona maarakamaan. 
mousil, "naa 10" x a7.3 chromosomil sthithicheyyunnu, athil 9 exonukal adangiyirikkunnu. vyathyastha subsellular compartmentukalil vyathyastha pravartthanangalum pravartthanavum ulla niha-3tii3, jebi6 cellukalil mouse naa 10, mna 10235, mna 10225 ennivayude rund badal spliesing uthppannangal report cheyyappettu.
sasyangal, fungus, ameebosova, archaeobacteria, protosova ennivayulppede vishakalanam cheytha mikkavarum ellah jeevajala raajyangalilum Naa10-nulla samavaakyangal thiricharinjittundu. ubacteriakalil, 3 ena-asattail traansfarasukal, rimi, rimj, rimmel enniva thiricharinjittunde nattukalumaayulla avayude kuranja sequence aidantitti anusarichu, riim proteinukalkku oru pothu poorvvikanillaayirikkaanum swathanthramaayi parinamikkanum saadhyathayund.
ghadana.
sais-exclusion chromatography vrithaakrithiyilulla dicroisavum soochippikkunnathu manushyan Naa10 proteininte moonnil rund bhaagavum gadanayillaatha oru vazhakkamulla sii-terminus ulkkollunna oru othukkamulla golaakrithiyilulla mekhalayaanu. 100 keey. dii hooloo-naatta (naa 10/naa 15) samuchayathinte ex-reey kristtal ghadana. oru valia hydrophobic interface avatharippikkunna oru enn-terminal α1-lupe-α2 segment adangiya oru saadhaarana gnad fold Naa10 sweekarikkunnundennum athu athinte ooksilari subunit Naa15, oru central asattail qoo-binding mekhala, mattoru enaa-asattail transferase aaya Naa50 leeii anubandha pradeshangalkk samanamaaya sii-terminal segmentukalumaayulla edapedalukal pradarshippikkunnuvennum pombe kaanichu. archaeal tii yude ex-reey kristtal ghadana. pii-lupe ulppede β4 num α3 num edayilulla looppukal ulppedunna asattail-qoo bindinginte onniladhikam vyathyastha reethikal velippeduthunna agniparvathamaaya naa10 report cheyyappettittund. sankeernamallaatha (Naa15 anboundu) Naa10 mattoru madakkam sweekarikkunnu liu 22, tyre 26 enniva Naa10-nte sajeeva saittil ninnu maarunnu, koodaathe gloo 24 (substrate bindingin naadayude kaattalisinum pradhaanamaan) ~ 5 Â upayogichu maattisthaapikkunnu, athinte falamaayi vyathyastha substrettukalude asattaileshan anuvadikkunna oru conformation undaakunnu. naa 15, hipec ennivayulla samuchayathil manushyante naa 10-nte ex-reey kristtal ghadana report cheythittundu.
78 num 83 num (krshrr) edayilulla hna 10-nte sii-terminasil oru pravarthanakshamamaaya nuclear localisation signal vivarichittundu.
pravartthanam.
naatta complexinte bhaagamaayi, serr, alaa, thru, gly, wall, sis thudangiya cheria side cheyinukalil ninnu aarambhich ribosome qoo-traansleshanal asattailettu proteinukalumaayum Naa10 bandhippichirikkunnu, inishyettar methionin (imed) methionin aminopeptidaseukal (mettaap) pilarthiyathinu sesham. koodaathe, noonn-ribosome-anubandha Naa10 vazhi vivarthanaananthara asattileshan sambhavikkam. ellah proteinukalilum ekadesham 40-50% pottensial naatta substrateukalaanu. koodaathe, oru monomeric avasthayil, substrate binding pokkatt naa 10-nte gadanaaparamaaya punakrameekaranangal acidic side cheyinukalulla enn-terminyude asattaileshan anuvadikkunnu. koodaathe, ene-asattail transferase pravartthanavum enn-terminal propionyl transferase pravartthanavum report cheythittundu.
proteinukalude ena-terminal asattileshan varshangalayi ariyappedunnundengilum, eee parishkkaranatthinte pravarthanaparamaaya anantharafalangal nannayi manassilakkiyitla. ennirunnaalum, shekharikkunna thelivukal Naa10 neey vividha signalling paathakalumayi bandhippichittundu, athil WNT/β-catenin, mapk, jacq/staatt, nf-kb enniva ulppedunnu, athuvazhi sell migration, sell saikkil kantrol, dna damages kantrol, caspace-dependent sell deth, pii53 dependent apoptosis, sell proliferation, autofagi, hypoxia ennivayulppede vividha sellular prakriyakal niyanthrikkunnu, ennirunnaalum hypoxiayekkurichu chila pradhana poruthakkedukalum Naa10 functionukalude isophome nirddishta phalangalum polum mousil report cheythittundu.
dii" yill naa 10 athyaavasyamaanu. melanogaster, "sii. elegans "umm" tii. bruzi ". ezz. serivisiya, "naa 10 function anivaaryamalla, pakshe vaii" naa 10 "δ koshangal nishabda inacheral tharam lokkasinte (" echml ") dee-adichamarthal, goo ghattathil praveshikkunnathil parajayam, thaapanila samvedanakshamatha, valarchayude takaraar enniva ulppede gurutharamaaya vaikalyangal pradarshippikkunnu. naa 10-nokktu elikal valare aduthide pravarthanakshamamaanennu report cheyyappettittund, ithu asthi vikasanathil oru takaraar kaanikkunnu.
rogam.
2001ll a c.109t> c (p.naa10" leeii serr37proo) vakabhedam ogden syndrome ulla bandhamillaattha rund kudumbangalil thiricharinju, prayamaaya roopam, craniophasial apakathakal, hypotonia, aagola vikasana kaalathamasam, cryptorchidism, cardiac aritmiyas ennivayude vyathyastha samyojanam ulppedunna ex-linked desorder. rogiyude fibroblastukal, maattam varuthiya roopaghadana, valarcha, migration savisheshathakal, tanmatra padanangal enniva soochippikkunnathu eee ezz 37 pii mutation naatta complexine thadassappeduthukayum naa 10 ensaimatik pravartthanam "inn vitro", "inn vivo" enniva kuraykkukayum cheiyunnu ennaanu.
koodaathe, syndromic ithara boudhika vaikalyangal, prasavaananthara valarchaa parajayam, asthikooda vaikalyangal ennivayude edaykkideyulla kesukalulla bandhamillaattha rund kudumbangalil Naa10-leeii mattu rund mutationukal (oru aankuttiyil r116w mutation oru penkuttiyil v107f mutation) vivarichittundu. fontaanalukal adaykkunnathu vaikuka, asthikalude praayam vaikuka, vishalamaaya kaalviralukal, neriya pectus kaarinaattam, pulmonary artari stenosis, atrial septtal takaraar, neenda kyudi edavela enniva penkuttikku undennu report cheyyappettu. kuttikk cheria kaikal/kaalukal, uyarnna kamaanamulla annaakk, vishalamaaya interdental speysukal ennivayundennu report cheyyappettu.
koodaathe, microfthalmia allengil anophthalmia, vikasana kaalathamasam, boudhika vaikalyam, asthikooda asaadhaaranathakal, pallukal, viralukal, kaalviralukal ennivayude vaikalyangal ennivayaal savisheshamaaya valare apoorvavum janithakamaayi vaividyamaarnnathumaaya ex-linked resussive disorder lense microfthalmia syndrome (elms) ulla orotta kudumbatthil "naa 10" yude introon 7 splies donner saittil (c.471 + 2 tii → eiii) oru splies mutation report cheyyappettu. rogiyude fibroblastukal kosha vyaapana vaikalyangal, staara 6 polulla retinoic assid signalling pathayil ulppedunna jeenukalude aniyanthrithamaaya pravartthanam, rettinol edukkunnathile kurravukal enniva pradharshippichu.
shekharikkunna thelivukal soochippikkunnathu, Naa10 function chaaparon functionte moduleshaniloode qoo-translation protein foldingine niyanthrikkukayum athuvazhi alsheimer rogathile visha amyloid aggregettukalude paatholajikkal roopeekaranatheyo yeesttile priyan [psi +] vyaapanatheyo baadikkukayum cheyyum.
Naa10 anubandha syndromsinecurichulla kooduthal vivarangal websaittil kaanam.10 ennam.coom

