
admi

agiranam, vitharanam, metabolism, visarjanam" ennivaykkulla pharmacokinetics, farmacology ennivayude churukkapperaan adme, koodaathe oru jeevajaalathinullile oru farmaceutical samyukthathinte swabhaavathe vivarikkunnu. naalu maanadandangalum tissuekalumaayulla mayakkumarunnu eksposharinte mayakkumarunnu nilavaaratheyum gathikolppaadanatheyum swaadheenikkunnu, athinaal oru marunnayi samyukthathinte prakadanatheyum aushadhashaasthraparamaaya pravartthanatheyum swaadheenikkunnu. chilappol, vimochanavum koodaathe/allengil vishaamshavum pariganikkunnu, ithu ladme, admett allengil ladmet nalkunnu.
gadakangal.
agiranam/bharanam.
oru samyuktham oru tissuevil athunnathinu, athu saadhaaranayaayi rakthapravaahathilekk kondupokanam-palappozhum dahananaalam (kudal agiranam) polulla mucus prathalangaliloode-lakshya koshangal edukkunnathinu munbu. samyukthathile layaneeyata kurayuka, dahanam shoonyamaakkunna samayam, kudal gathagatha samayam, aamaashayathile raasa asthiratha, kudalbhithi thulachukayaraanulla kazhivillaayma thudangiya gadakangalellaam vaayiloode nalkia sesham oru marunnu agiranam cheiyunnathinte alavu kuraykkum. agiranam cheyyappedunnathu samyukthathinte jaiva labhyathaye nirnnayikkunnu. vaayiloode kazhikkumbol moshamaayi agiranam cheiyunna marunnukal intravinus allengil inhaleshan (udha.jii. sanamivar). bharanathinte vazhikal oru pradhana parigananayaan.
vitharanam.
samyuktham athinte ifakttar saittilekk kondupokendathundu, mikkappozhum rakthapravaahathiloode. avide ninnu, samyuktham peshikalilekkum avayavangalilekkum, saadhaaranayaayi vyathyastha alavukalilekku, vitharanam cheythekkaam. systemic rakthachamkramanathilekku praveshichathinushesham, intravascular kuthivayppiloodeyo allengil vividha extra sellular saittukalil ninnu agiranam cheytho, marunnu athinte plasma saandrata kuraykkunna niravadhi vitharana prakriyakalkku vidheyamaakunnu.
oru compartmentinu idayil mattoru compartmentilekku oru marunninte reversible transfer ennaanu vitharanathe nirvachichirikkunnathu. praadeshika raktapravaaha nirakk, tanmatra valippam, dhruveekaranam, serem proteinukalumaayi bandhippikkal enniva mayakkumarunnu vitharanathe badhikkunna chila gadakangalil ulppedunnu, ithu oru sankeernnatha srishtikkunnu. raktha-mastishka thadassam polulla chila swaabhaavika thadassangalil vitharanam gurutharamaaya prasnamaakaam.
metabolism.
shareerathil praveshichayudane samyukthangal pottitherikkaan thudangunnu. cytochrome pii 450 ensimeukal ennu vilikkunna redox ensaimukalaanu karalil cheria-tanmatra marunnu mettabolisatthinte bhooribhaagavum nadathunnathu. metabolism sambhavikkumbol, prarambha (maathru) samyuktham metabolittukal ennariyappedunna puthiya samyukthangalayi parivartthanam cheyyappedunnu. metabolittukal aushadhashaasthraparamaayi nishkriyamaakumbol, metabolism maathru marunninte nalkunna alavu nirjjeevamaakkukayum ithu saadhaaranayaayi shareerathil undaakunna phalangal kuraykkukayum cheiyunnu. metabolittukal aushadhashaasthraparamaayi sajeevamaayirikkam, chilappol maathru marunninekkaal kooduthal (prodrug kaanuka).
visarjanam.
samyukthangalum avayude mettabolittukalum shareerathil ninnu visarjjanathiloode neekkam cheyyendathundu, saadhaaranayaayi vrukkakaliloodeyo (moothram) allengil malathiloodeyo. visarjanam poortthiyaayittillengil, videsha padaarthangalude shekharanam saadhaarana mettabolisathe prathikoolamaayi badhikkum.
mayakkumarunnu visarjanam nadakkunna moonnu pradhana sthalangalundu. vrukkayaanu ettavum pradhanappetta sthalam, moothrathiloode uthppannangal puranthallappedunnathu ivideyaanu. karalil aarambikkukayum maalinya uthppannangal allengil malam ennivaykkoppam uthppannangal puranthallappedunnathuvar kudalilekku kadannupokunna prakriyayaan pittha visarjanam allengil malavisarjanam. visarjjanathinte avasaanathe pradhana reethi shwaasakoshathiloodeyaanu (udha.jii. anaesthetic vaathakangal).
vrukkayiloode marunnukalude visarjjanathil 3 pradhana samvidaanangal ulppedunnu
vishaamsham.
chilappol, samyukthathinte saadhyathayullatho yadhaartha vishaamshamo kanakkiledukkunnu (admi-tox allengil admett). vishaamsham nirnnayikkaan upayogikkunna maanadandangalil median lethal doses (eldie 50), therapeutic indux enniva ulppedunnu.
kyu. ezz. pii. aarr allengil kyusar polulla reethikaliloode samyukthangalude admi-tox gunangal pravachikkaan computational rasathanthranjar shramikkunnu.
bharanathinte paatha adme vimarsanaathmakamaayi swaadheenikkunnu.

