
aswoodin

reverse traanscriptes inhibittaraayi pravartthikkunna oru aantivairal marunnaan aswoodin. heppattaitis sii chikilsaykkaayi kandethiya ithu pinneedu aids, covid-19 thudangiya mattu vairal rogangalkkethire upayogikkunnathinaayi anweshichu, ithinaayi chainayil ithinu vyavasthaapitha amgeekaaram labhichu.
2007laanu aswoodin aadyamaayi kandethiyathu. kovidinu 7 divasathinu 350 chainees yuwan aanu vila.
medical upayogangal.
2021 joolaiyil, chainayil thaazhepparayunna soochanakalkkaayi aswoodin vyavasthaapithamaayi amgeekarikkappettu "echuaivi-1 nte uyarnna vairal-looad kesukal chikilsikkaan, nucleoside reverse-traanscriptes inhibittarumaayum noonn-nucleoside reverse-traanscriptes inhibittarumaayum samyojippichu". amgeekaara vaachakam ithine eratta reverse traanscriptes, iif inhibittar enningane vivarikkunnu.
2022 joolaiyil, muthirnnavaril covid-19 nuu aswoodinu adiyanthara vyavasthaapitha amgeekaaram labhichu.
prathikoola phalangal.
nirmmaathaav parayunnathanusarichu, echuaivi rogikalil doravirin, tenofovir disoproxil fumert ennivayumaayi chernnu efncyude randaam ghatta pareekshanangal rund marunnukalumayi samyojippicha laamivudinekkaal samanamaaya, ennaal mithamaaya prathikoola phala profile kandethi. thalakarakkam, uyarnna karal ensimeukal, chharddi, uyarnna alkaline phosphatase enniva valare saadhaaranamaaya (10 sathamaanathiladhikam) paarshwafalangalil ulppedunnu. ookkaanam, uyarnna rakthathile kozhuppukal, panii, urakkamillaayma, ksheenam, vayarilakkam ennivayaanu saadhaarana (1 sathamaanathiladhikam) paarshwafalangal. slideukalilum marunnu paakkej insertilum jeniyoon vishadamaaya nambarukal nalkunnu. chainees paakkej insertinte thudakkathil oru boxed munnariyipp undu, ithu "kevala neutrophil ennathil kuravu, motham bilirubin vardhana, glutathiyon aminotranspherase vardhana, rakthathile glucose vardhanavu" ennivayude apakadasaadhyatha vivarikkunnu.
covidil maathram upayogicha efnckaayulla cheria (enn = 10) ooppan-label pailat patanam prathikoola sambhavangalonnum report cheythitilla. kovidile efnvkaayulla moonnaamathe valia ghatta padanatthil ninnu vivarangalonnum labhyamalla.
manushyetara maathrkakal.
amez testtil "inn vitro", cl testtil "inn vitro", elikalil micro nucleus testtil "inn vitro" ennivayil aswoodin mutagenic aanennu kandethiyittundu.
elikalkkum muyalkkum prathyulpaadana samvidaanathinu aswoodin vishamaan. purushanmaaril kaanapedunna paramavadhi prathyulpaadana noval 5 milligram/kilogram/dii umm sthreekalkku 0.5 milligram/kilogram/dii umm aanu. ithu elikalude mulappalil ninnu puranthallappedunnu; elikalude naaykkuttikalude noval 1.5 milligram/kilogram/dii aanu.
maathrukaa mrugangalude rogaprathirodha samvidaanam, asthimajja, dahanavyavastha ennivaykku aswoodin pradhaanamaayum vishamaan. vittumaaraatha novalukal 0.5 milligram/kilogram/dii (elii, 3 maasam), 0.3 milligram/kilogram/dii (elii, 26 aazhcha), 0.1 milligram/kilogram/dii (beagle naaya, 1 maasam, 39 aazhcha) ennivayaanu. thaarathamyappeduthumbol, echuaivi chikilsaykkulla vittumaaraatha manushya doses 0.05 milligram/kilogram/dii aanu, reference 3 milligram dose sharashari chainees body maas 59.5 kilogram (2014) umm upayogikkunnu.
charithram.
shengshou sarvakalaashaalayile chaang juun-biavo samarppicha pettantilaanu aswoodin aadyamaayi saahithyathil kandethiyathu. 2009 ll rochile gaveshakar ithine hep sii rna polymerase inhibittar "inn vitro" aayi swathanthramaayi kandethiyappol ithinu athinte nilavile peru labhichu. thudarnnulla varshangalil, chainees shaasthranjar ithu niravadhi lakshyangalkkayi "inn vitro" pareekshichu, ettavum pradhanamaayi echbivi (manushyan thaaravum), echtlv-1, reverse traanskriptesulla rund virusukal.
2011 ll chaang grouppinte "inn vitro" parisodhanakal positteev phalangal nalkiyappol ithu aadyamaayi oru echuaivi chikilsayaayi nirddeshikkappettu. 2014ll elikalile athinte ooral pharmochinetics vishadeekarichu. randaam ghatta patanam (nct04109183) 2019 maarchil yadhaartha biotech poortthiyaakki. 2020 augustil, eee padaartham "inn vitro" yeei thadayunnuvennu chaang group kandethi. athe maasam thanne chainayude drugg regulator (enn. emm. pii. eiii) amgeekaara prakriya vegathilaakkaan theerumaanichu, ithine phastt-inn-klaas marunnayi mudrakuthi. 2021 joolaiyil, enn. emm. pii. eiii. echu. aii. vii-1 nuu vyavasthaapitha anumathi nalki. aaa varsham octoberil prasidheekaricha chainees medical association chainees sii. dii. siyum 2021 echu. aii. vii chikitsa shupaarsha cheiyunnathil ithu ulppeduthi. kauthukakaramennu parayatte, pareekshana roopakalppana vishadamaakkunna oru jenalilum eee padanathinaayi pareekshanatthinte poornna phalangalonnum labhyamakkiyittilla. phalangalude bhagangal mayakkumarunnu monographylum randaamathethinte websaittil labhyamaya enhsaikaayi yadhaarthamaayi nirmmicha 2022 slideukal deckilum kaanikkunnu.
2020 oode efnc chila corona vairasukale "inn vitrokale" thadayunnathaayi kandethi, ithu covidil athinte upayogathinulla thaalpparyathilekku nayichu. neriyathum mithamayathumaaya kesukalekkurichu 2020-ll oru ooppan-label pailat patanam nadatthi, neriya positteev phalangal. 2022ll chainayil moonnaam ghatta pareekshanam nadannu. praadeshika moonnaam ghatta pareekshanathetthudarnnu 2022 joolaiyil chainayude drugg regulator covid-19 chikilsikkaan ithu upayogikkunnathinulla vyavasthaapitha anumathi nalki. eee pareekshanathekkurichulla vishadamaaya vivaranam oru jenalilum prasidheekarichittille samsthaana maadyamangal developeril ninnulla chila kanakkukal udharikkunnu "efnc group 7 divasathinullil 40 sathamaanam klinikkal mechappeduthal, 11 sathamaanam niyanthranathilaanennathinni". atharam "mechappeduthal" engane nirvachikkappedunnuvennu vyakthamalla.
samoohavum samskaaravum.
eee marunnin realinu rund vyathyastha vyaapaaranaamangalundu echuaivi upayogathinaayi nyoo curr (aksharaarthatthil "duval nyoo aids inhibittar"), covid upayogathinaayi nyoo curr (aksharaarthatthil "phaast extra saphe"). generic marunnukal labhyamalla.
jeniyooninu eee marunninumaayi bandhapetta oru pettant undu shengshou sarvakalashaalayil ninnu vangiya 2 '-fluorin-4'-pakaramulla nucleodideukalude muzhuvan classilum yadhaartha pettant 2007. marunnu samanvayippikkunnathinu mattu rund chainees pettantukal google pettantukalil kaanappedunnundengilum udamakalkku jeeniyoonumaayi bandhamundennu thonnunnilla. rochinu 2002-ll cna028118480a (cn1516590a) enna pettant undaayirunnu, ithu 4 '-pakaramulla nucleodideukalude vishalamaaya vibhagathilaanu. puthiya udamayaaya riboscience phees adaykkunnathu nirtthiyathine thudarnnu 2019ll pettant raddaki.

