histiyosaitt

mono nuclear phaagosait sisttathinte bhagamaaya (reticuloendothelial sisttam allengil lymphoreticular sisttam ennum ariyappedunnu) kasherukkalude koshamaan histiyosaitt. mono nuclear phagocytic sisttam jeeviyude rogaprathirodha samvidaanathinte bhagamaanu. histiyosaitt oru tissue macrophage allengil dendritik sell aanu (histtiyo, histoyude cheria, athaayath "tissue", saitt, athaayath "sell"). neutrophillukal avarude ayuss avasaanichukazhinjaal avaa neekkam cheyyuka ennathaanu avarude joliyude oru bhagam. 
vikasanam.
oru stem sellil ninnulla gunanathiloode asthimajjayil ninnaan histiyosaittukal uruthirinjathu. uthbhavicha koshangal asthimajjayil ninnu monocytukalaayi rakthathilekku kudiyerunnu. avaa shareerathiloode sanjarikkukayum vividha avayavangalil praveshikkukayum cheiyunnu, avide avaa mono nuclear phagocytic sisttathinte (emm. pii. ezz) bhagamaaya histiosaittukalaayi verthirikkappedunnu.
ennirunnaalum, "histiyosaitt" enna padam munkaalangalil onniladhikam aavasyangalkkaayi upayogichittundu, "histosaittukal" ennu vilikkunna chila koshangal monoosaitik-macrophage lainukalil ninnu uruthirinjathaayi thonnunnilla. histiyosaitt enna padam rakthavyavasthaykk purathulla monoosait uthbhavathil ninnulla oru koshatthe soochippikkaan kazhiyum, athaayath oru tissue (rheumatoid aarthraittisilennapole rheumatoid nodyoolukalude fibrinoid necrosisinu chuttumulla palisading histiyosaittukal).
chila srothassukal langerhans sell derivetteevukale histiosaittukalaayi kanakkakkunnu. langerhans sell hysteocytosis eee vyaakhyaanam athinte peril ulppeduthunnu.
ghadana.
histiyosaittukalkk pothuvaaya hystological, immunophenotypical swabhaavasavisheshathakalundu (immunosteyinukal prakadamaakkunnu). ivayude cytoplasm eosynophilic aanu, koodaathe ithil variable alavil lysosomukal adangiyirikkunnu. igg, igg compliment thudangiya opsoninukalkkulla membran resepterukal avaa vahikkunnu. avaa ell. sii. eiii. (leukosite kooman aantijanukal) sii. dii. 45, sii. dii. 14, sii. dii. 33, sii. dii. 4 (tii helper cellukalum prakadippikkunnu) enniva prakadippikkunnu.
macrophageukalum dendraitik koshangalum.
phagocytosis, aantijan avatharanam enningane rund vyathyastha pravarthanangaliloode eee histiyosaittukal rogaprathirodha samvidaanathinte bhagamaanu. macrophageukaludeyum aantijan avatharanathinteyum pradhana prakriyayaan phagocytosis, dendraitik koshangalude pradhana savisheshatha (avayude nakshatram polulla cytoplasmic prakriyakal kaaranam vilikkappedunnu).
vividha paaristhithika (tissue sthaanam), gm-csf, tnf, il-4 thudangiya valarchaa gadakangalude swaadheenathil vyathyasthamaaya vyathyaasangalkk vidheyamaaya (histiyosaittukal) saadhaarana asthi majja mungamikalaaya koshangalil ninnaan macrophageukalum dendritik koshangalum uruthirinjathu. histiyosaittukalude vividha vibhagangal avayude roopaghadana, phenotype, valuppam ennivayaal verthirichariyaan kazhiyum.
langerhans koshangal.
koshangalude oru upavibhagam langerhans koshangalayi verthirikkunnu; eee pakwata schwamous epithelium, lymph nodukal, pleeha, bronchiolar epithelium ennivayil sambhavikkunnu. langerhan koshangal aantijan avatharippikkunna koshangalaanenkilum avaa kooduthal vyathyaasathin vidheyamaayittundu. courtical thymocytukal (thymus grandhiyude courtexinte koshangal) pole charmmatthile langerhans koshangalum koshangalum prakadippikkunnu. avaa ezz-100 prakadippikkukayum cheiyunnu, avayude cytoplaasathil birbeck granuelukal ennariyappedunna ultra structural inclusions polulla tennies-raakkat adangiyirikkunnu.
klinikkal praadhaanyam.
hysteocytosukal neoplaasiyakale vivarikkunnu, athil proliferative sell histiosaittaanu. langerhansinte sell hysteocytosis, haemophagocytic lymphohystiocytositosi ennivayaanu ettavum saadhaaranamaaya histiyosaitt vaikalyangal.

