
phiin

manushyaril "phine" jeane encode cheiyunna oru ensaimaanu proto-oongoojeen tyrosine-protein kainas phine (p59-phine, slk, siin, emjisi 45350, jeane aidi 2534).
tii-sell, neuronal signalling ennivayumaayi bandhapetta kainesukalude src kudumbatthile 59-kda amgamaanu phiin. eee signalling paathakalile thadassangal palappozhum vividatharam arbudangalude roopeekaranathil swaadheenam cheluthunnu. proto-oongoojeen enna nirvachanam anusarichu, koshavalarchaye niyantrikkaan sahayikkunna proteinukalkkulla phine kodukal. athinte dna shreniyile mattangal athine oru oongojenaayi parivartthanam cheiyunnu, ithu saadhaarana kosha niyanthranathinu prathyaaghaathangalulla mattoru protein roopeekaranathilekku nayikkunnu.
protein-tyrosine kainas oongoojen kudumbatthile amgamaanu phine. koshavalarchayude niyanthranatthil ulppettirikkunna membranumaayi bandhapetta tyrosine kainesine ithu encode cheiyunnu. protein phosphaattidilinosittol 3-kinesinte pii 85 subunitumaayi bandhappedukayum phiin-binding proteinumaayi samvadikkukayum cheiyunnu. vyathyastha isophomukal encode cheiyunna pakaramaayi spliesed traanskript vakabhedangal nilavilundu.
charithram.
thiricharinja aadyathe proto-oongoojen aaya kainaasukalude (sfk) src-kudumbatthile amgamaanu phiin. 1976ll src-famili kandethiyathode 1989ll jeey. jeey. kku vaidyashaasthrathinulla nobal sammanam labhichu.emm bishop iii.emm. warmes. 1986ll "vii-athe", "vii-eph. jii. aarr" ennivayil ninnu uruthirinja probukaliloode siin allengil ezz. ell. keey ennaanu phiin aadyamaayi thiricharinjathu."ezz. eph. keey. sukalude oru saadhaarana savisheshatha avaa saadhaaranayaayi arbudangalil niyanthrikkappedunnu ennathaanu. kosha roopaghadanayudeyum chalanakshamathayudeyum niyanthranatthil phaak, paxilin (pxn) ennivayumaayi samvadikkunnathil phiin athinte kudumbamgangalil ninnu pravartthanaparamaayi vyathyasthamaan.
pravartthanam.
raas sajeevamaakkunna integrinukalude signalling pathayil adangiyirikkunna oru proteinaan phiin. risapttar allatha tyrosine protein kainesukalude src kudumbatthile amgamaaya oru tyrosine-nirddishta phospho-transferase aanu phine. (eee kudumbatthil eiii. bii. ell, ezz. aarr. sii, phokkal addition kainas, jaanas kainas ennivayum ulppedunnu.) neuronal vikasanavum tii-sell signalingumaayi saadhaaranayaayi bandhappettirikkunna niravadhi sell uparithala resepterukalude thaazhekku sthithicheyyunnu. phiin sajeevamaakumbol athu koshangalude valarchaykkum chalanakshamathaykkum nirnayakamaaya prakriyakale nayikkunna tanmatra signalukalude thaazhekkulla sajeevamaakkalin kaaranamaakunnu. phine praadhamikamaayi plasma membranile cytoplasmic laghulekhayil praadeshikavalkkarikkuppadu, avide ithu vividha signalling pathakalil ulppedunna pradhana lakshyangalil tyrosine avashishtangale phosphorylate cheiyunnu. phine vazhi taargett proteinukalude tyrosine phosphorilation onnukil taargett protein pravartthanatthe niyanthrikkunnathinum koodaathe/allengil mattu signalling thanmaathrakale recruit cheiyunna taargett proteinil oru binding saitt srishtikkunnathinum sahayikkunnu. phiin oru tumour suppressor koodiyaanu. eee saadhaarana jeevashaasthrathil vittuveezhcha cheyyumbol, parivartthanam cheyyappetta phiin pree-invasivil ninnu invasive, aathyanthikamayi metaastaasis ennivayilekkulla paatha pinthudarnnu saadhaarana koshangalude neoplastic parivartthanatthil ulppedunnu.
andakoshavum beejavum samvadikkumbol sambhavikkunna drutha inositol trisphosphate-mediated kaalsyam signalling ulppedeyulla beejasankalanathil phiin oru pradhana punk vahikkunnathayi kaanapedunnu. neuronukalekkaalum tii-sellukalekkaalum oosaittukalil phine expression levelukal valare kooduthalaanu, ithu oru 'oosaitt-nirddishta kinace' aanennu nirddeshikkappettittund. oosaitt pakwata samayat oosaitt courtexile naadakeeyamaaya biochemical maattangalkk phiin utharavaadiyaanennu niravadhi padanangal choondikkaanikkunnu. vrishanathinullil beejatthinte thalayum acrosome shariyaayi roopappeduthunnathilum phiin oru pradhana punk vahichekkaam, koodaathe beeja acrosome prathikaranatthil adhika punk vahikkunnundaakam.
signalling pathakalil punk.
cancer eee saadhaarana paathakalude aniyanthrithamaaya pravarthanamaayathinaal saadhaarana jeevashaasthrathil finte pankinekkurichulla dhaarana canceril athinte pankinekkurichu manassilaakkunnathin nirnaayakamaan. eathu pathakalil phiin ulppedunnu ennu ariyunnathu eee aniyanthrithamaaya signalling kuraykkunnathinu saadhyathayulla pharmacological ejantumaarude vikasanathinu pradhana ulkkaazhcha nalkum.
oru prathyeka signalling sisttathil phiin functionte aavasyakatha thirichariyaan kuranjathu moonnu upakaranangalenkilum upayogapradamaanu
eee upakaranangal upayogichu, inipparayunna signalling paathakalkk phiin aavasyakatha kaanichittundu tii, bii sell risapttar signalling, integrin-mediated signalling, groth factor, saitokin risapttar signalling, platelet aaktiveshan, ayoon chaanal function, sell addition, aaksan maargganirddesham, beejasankalanam, mitosisilekkulla praveshanam, prakrithidatha kolayali koshangal, oligodendrocyteukal, keraattinosaittukal ennivayude vyathyasam. tii cellukalil ninnulla tlr-madhyastha rogaprathirodha prathikaranagalilum finninu oru pradhana pankundu.
ashayavinimayam.
phiin ivayumaayi edapazhakunnuvennu kaanichittundu
cancer biologyil punk.
kainaasukalude src kudumbam saadhaaranayaayi "aakramanathilum tumour purogathiyilum, epithelial-tuu-messenkymal transition, angiogenesis, mettaastaasisinte vikasanam" ennivayile athinte pankumaayi bandhappettirikkunnu, ivayellaam cancer purogathiyude mukhamudrakalaanu. sellular valarchayilum vyaapanathilum finte saadhaarana pravartthanam cancer koshangalude purogathiyilum metaastaasisilum prayojanappedutthaanulla saadhyathayund. finte amithamaya aavishkaaram saadhaarana koshangalil roopaghadana parivarthanatthinu kaaranamakumennum "aankarej-swatantra valarchayum pradhana roopaghadana maattangalum" vardhippikkumennum kandethiyittundu." 
inipparayunna arbudangalumaayi bandhappett phiin overexpression padikkappettittund prostettu cancer, glioblastoma multifom, thalayileyum kazhuthileyum schwamous sell carcinoma, pancreatic cancer, vittumaaraatha melogenic leukemia, melanoma. eee amithamaya aavishkaaram prostettu canceril "aanti-apoptotic pravartthanam oof aakda" prothsaahippikkunnu, athaayath eee koshangalkk saadhaarana kosha marana pathakal (kaansarinte oru saadhaarana mukhamudra) ozhivakkaanulla kazhivu labhichu. koodaathe, glioblastoma multifomil, src, phiin enniva tumour aakramanathinum cancer koshangalude atijeevanathinum kaaranamaaya "oongoojenik egfr signalinginte phalangal" aanennu kandethiyittundu.
koshangalude kaimaattatthilum anubandhathilum finninte saadhaarana punk kyaansar valarchaykku integrin, phack ennivayude saadhaarana kosha jeevashasthram upayogikkaan prapthamaakkunnu. koshatthinte aakruthiyeyum chalanakshamathayeyum swaadheenikkunna signalukal ayaykkunnathinu extra sellular maatriksumaayi samvadikkunna oru sell uparithala resepteraanu normal integrin. phokkal addition cytukalilekku recruit cheyyappedukayum koshangalude chalanatthil pradhana punk vahikkukayum cheiyunna oru tyrosine kinace aanu normal phack. aakruthiyeyum chalanakshamathayeyum badhikkunna phiin traansmitted sellular evantukalude madhyasthathayil eee saadhaarana pathakal oru pradhana punk vahikkunnu.eee paathayude oru vittuveezhcha cheytha pathipp cancer koshangale aakruthiyum chalanakshamathayum maattaan praapthamaakkukayum vipulamaaya aakramanathinum metaastaasisinum saadhyatha vardhippikkukayum cheyyum. kyaansar purogathiyil finte pankinekkurichulla anweshanathilulla adhika pathakalil iva ulppedunnu jidipesukal, raas, erc, mapp ennivayude raakk, roow kudumbam.
ekkaaranathaal, cancer virudha chikitsa gaveshanathinte oru saadhaarana lakshyamaanu phiin. phiin thadayunnathu (mattu esfkekaleppole) koshavalarcha kuraykkunnathinu kaaranamaakunnu. koodaathe, elikalil praadhamika tumourukalude valippam kuraykkaan "endogenous finninte oru prathyeka ethiraaliyaaya kainas-dedd-phiin (keddy-phiin)" enna padaprayogam kandethi. faininte savisheshamaaya thirichariyal gunangal prathyekamaayi lakshyamidunnathum fackineyum pxnne thadayunnathum valare phalapradamaaya tanmatra lakshyamitta samyojana cancer therapy srishtikkaan saadhyathayund. alshimezhs rogathinulla saadhyathayulla chikilsakalaayi phiin inhibittarukalum paryavekshanam cheyyappedunnu.

