
sayanasin

trianisukalude koottatthil pedunna oru kalanashiniyaanu sayanasin. sayanasin prakaashasamshleshanathe thadayukayum athinaal oru kalanashiniyaayi upayogikkukayum cheiyunnu.
charithram.
vaarshika pullukalum vishalamaaya ila kalakalum niyantrikkaan sayanasin oru kalanashiniyaayi upayogikkunnu. ithu attrassin pole triasin kalanaashinikalude koottatthil pedunnu. prakaashasamshleshanathe thadayunnathiloodeyaanu eee keedanashinikal pravartthikkunnathu. upayogikkunna sayanaseenil bhooribhaagavum chorinaayi upayogikkunnu. 1985ll upayogicha sayanaasinte 96 sathamaanavum ithaayirunnu. paristhithi samrakshana ejansi (iii. pii. eiii) 1984ll sayanaasinte aarogyaparavum paaristhithikavumaaya prathyaaghaathangalekkurich oru profile undaakki. 
1971ll 'bladks', 'fortol' ennee perukalil sayanasin shell upayogichu vipaniyilethichu. sayanasinum mattu maasikakalum madhya padinjaaran amerikkayilum american ikyanaadukalilum ettavum kooduthal upayogikkunna kalanaashinikalude koottatthil ulppedunnu. 
2002ll europian union keedanaashinikalude daattaabes sayanasain oru kalanashiniyaayi upayogikkunnathu amgeekarichilla. apakadakaramaaya padaarthangalude pattikayil ithu 1986 ll thanne oru terratogen aayi tharamthirichittundu.
ghadanayum prathikaranavum.
2-chloro-4-(1-syaano-1-methylthyl-amino)-6-ethilaamain-1,3,5-triasine ennathinte pothuvaaya peraanu sayanasin. eee samyukthathinte tanmatra soothravaakyam aanenkil, tanmatra bharam 240.695 g/mol aanu. veluthatho niramillaatthatho aaya oru kristalin kharapadaarthamaanu sayanasin. dravanaangam 166.5-167.0 °C aanu. logue 2.22 aanu. 
neutral, alpam acidity/basic meediyakalil sayanasin valare reactive allah, sakthamaaya aasidukalum baseukalum ithu hydrolyse cheiyunnu. ithu choodu, prakasham, jalavishleshanam ennivaykku sthirathayullathaanu. praayogika saahacharyangalil yuu. vii. vikiranathinum ithu sthirathayullathaanu. sayanasin choodaakkumbol vighadikkum. ithu hydrajan chloride, naitrajan ooksaidukal, sayanaidukal ennivayude naashakaramaaya puka uthpaadippikkunnu.
vividha keedanaashinikalil ninnulla oosonumaayulla ettavum kuranja prathikaranasheshiyulla sthirathayaanu sayanasin. naalu vyathyastha sasyanashini grouppukalil, sayanasin mannil ettavum vegathil apachayam varuthunnu.
synthesis.
6, 4 sthaanangalil yathaakramam oru ethyl aminoy oru amino group upayogichu maattisthaapikkunna oru chloro-<aii. dii. 1>-triasinaanu sayanasin. sayanurik chloride ethilaamain, 2-amino-2-methylpropionitrile ennivayumaayi prathipravarthippichundu ithu thayyarakkam.
labhyamaya foomukal.
layikkunna saandrata, ozhukaan kazhiyunna saandrata, emulsible saandrata, nanaykkaan kazhiyunna podi, granular uthppannam enningane sayanasin labhyamaan.
pravartthana samvidaanangal.
sayanasin prakaashasamshleshanathe thadayukayum athinaal oru kalanashiniyaayi upayogikkukayum cheiyunnu. ithu anaavashya sasyajaalangale, prathyekichu vividha tharatthilulla kalakal, pullukal, maram kondulla chedikal ennivaye nasippikkunnu. foto sisttam II-nte thaazhthunna bhaagathaayirunnu inhibishante praadhamika sthalam. praadhamika electron sweekarthaavum (q) electron transport cheyinte plaastokvinon poolum thammilulla electron kaimatta ghattathe avaa thadayunnu. 
sayanasin ettavum vishamulla triasine kalanashiniyaanu, ithu janana vaikalyangalkkum mutationukalkkum aathyanthikamayi cancerinum kaaranamakum.
metabolism.
sayaanaasinte metabolism pathakal vividha mrugangalkkum sasyangalkkum vivarichittundu. mrugangalude maathrkakalil (elikal, naaykkal, pashukkal) sayanasin kudalil vegathil agiranam cheyyappedunnuvennu vividha padanangal theliyichu. agiranam cheyyappedunna sayanaasinte apachayathinu inipparayunna upapachayam ulppedunnu dii-alchylation glutathayonumaayulla samyojanavum, ithu vyathyastha mettabolittukalkk kaaranamaakunnu. eee upapachayam vazhikalkku vidheyamaaya sesham upapachayam moothrathilum malatthilum shareeram vidunnu. udaaharanathinu, elikalil sayanasin vaayil kazhichathinu sesham moothrathilum malatthilum ezhu metabolittukal kandethi. sasthanikalile sayanasinte apachayathinte mattoru pradhana maarggam ethyl grouppinte vilavu vardhippikkunna enn-dii-ethylationaanu. swatantra ethyl group pinneedu shwasanathiloode visarjjikkappedum.
sasyangalil thaazhepparayunna upapachayam pathakalil jalavishleshanam, enn-dii-alchylation, glutaathayonumaayulla samyojanam enniva ulppedunnu, ithu vyathyastha mettabolittukalkk kaaranamaakunnu (chuvadeyulla chithratthil kaanichirikkunnu).
soochanakal.
daanyangal, cholam, cholam, parutthi, gothamb ennivayude vaarshika pullukalum vishalamaaya ila kalakalum niyantrikkaan sayanasin oru kalanashiniyaayi upayogikkunnu.
falaprapti.
sayanasin thaazhepparayunna dosukalil upayogikkunnu kalakal thadayunnathinu, 0,14 kilogram/chathurashra kilometer-0,54 kilogram/chathurashra kilometer enna alavil upayogikkunnu. nilavilulla kalakal chikilsikkaan, 0.136 kilogram/chathurashra kilometer-0,23 kilogram/chathurashra kilometer upayogikkunnu.
mrugangalilum aalgakalilum eldie50/elsie50/isi50 thaazhepparayunnavayaanu
elikalude bhakshanathil 25 ppm sayanasin aavarthichu kalarthiyathinu sesham visha efakttukalonnum kandilla.
prathikoola phalangal.
vadakke amerikkayile onniladhikam raajyangalilum netherlandsile bhoogarbhajalangalilum uparithala jalatheyum kudivellatheyum malinamakkunnathaayi sayanasin kandethi. ennirunnaalum, sayanasin allengil sayanasin degradation uthppannangal bhakshanathil kandethiyitla. kaanadayil ninnum netherlandil ninnumulla vivarangalude adisthaanathil, kudivellatthil ninnulla upabhogam prathidinam 0.2-0.3 μg/enna kanakkinu chuttum aanu. athinaal manushyarkk saadhyamaaya visha efakttukal kaaranam 0.198 μg/kilogram shareerabhaarathinte paramavadhi moolyam nischayikkunna samghadana.
koodaathe, mukalilulla pattikayil kaanunnathupole, bhouma mrugangale apekshichu sayaanaasinte saandrata valare kuravaayathinaal jalajeevajaalangale badhikkunnu. sayanasin vegathil mannil ninnu chuttumulla vellathilekku kazhukunnu enna vasthuthayumayi samyojippichu, jala aavaasavyavasthaye sayanasin ettavum kooduthal vittuveezhcha cheiyunnathaakkunnu.
vishaamsham.
sayanasin polulla triasin kalanaashinikal chilatharam sasyangalkk valare vishaamshamullavayaan. athukondaanu prathyeka inam vishalamaaya ila kalakale kollan avaa valare phalapradamaakunnathu. eee prakriyaykku aavashyamaaya pradhana proteinukale bandhippikkunnathiloode sayanasin photosistam II-nte pravarthanarahithathaykku kaaranamakum. prakaashasamshleshanathile eee pradhana ghattam paraajayappedumbol, oru chedikku athinte valarchaykkum mettabolisathinum nirnayakamaaya panchasaara utppaadippikkaan kazhiyilla.
manushyaril vishaamsham.
sayanasinumaayulla sanbarkkam sanbarkkathinte theevrathaye aashrayich dermattaittisin kaaranamakum. koodaathe, uyarnna alavil sayanasin kazhikkumbol, kadutha vishaamsham sambhavikkam. sayanasin puka shwasikkunnathu vaayumaargathil prakopippikkaan idayaakkum.
sayanasinte arbudakaarikalaaya phalangal valarekkaalamaayi vyakthamalla. ennirunnaalum, eee kalanashini manushyaril arbudamundaakkunna phalangal undakkaan saadhyathayilla. sayanasin cancer undaakkunna onnallennu poornnamaayum sthireekarikkaan kooduthal gaveshanam aavasyamaanu. athukondaanu eusepa sayanasine oru group sii kemikkalaayi rettucheythath; ithinartham ithu carcinogenic aakam ennaanu.
mrugangalil vishaamsham.
penn elikalude elech, prolaaktin sravathe swaadheenikkaan attrassinu kazhiyumennu gaveshanangal theliyichittundu. eee hormon mattangal pityoottariyude pravartthanatthil maattam varuthiyathaanu. sayanasin attrassin enna athe tharam kalanaashinikalil pedunnathinaal, sayanasin elikalude hormon avasthayil cheluthunna swaadheenam onnuthanneyakaam. nalkunna alavu anusarichu elikalude thalachorile gaba-resepterukale sayanasin swaadheenichekkaam. ithu jii. enn. aarr. echu-releasine thadassappeduthiyekkaam.
chila jeevajaalangalude bhroonavikasanathil sayanasin vaikalyangalkk kaaranamaayekkam. silurana tropicalisil, sayanasin polulla triasin kalanaashinikalkk vidheyamaakunnathu gurutharamaaya asaadhaaranathakalkk kaaranamakum. eee phalangal manushyarilum kaanaan kazhiyumo ennu vyakthamalla. koodaathe, elikalude bhroonangalile netra vaikalyangal sayanaseente visha gunangalude falamaayirikkaam. 
vyathyastha trisine kalanaashinikal prathyeka mruga enangalil oru samanvayaparamaaya prabhavam cheluthunnathaayi kaanapedunnu. sayaanaasinte kaaryatthil, attrassin chironomous tentance polulla lakshyamallaatha enangalil swaadheenam cheluthum. attrassinu midjukalile pii 450 ensaimukalude pravartthanatthe swaadheenikkaan kazhiyum, athinaal eee kalanaashinikalude vishaamsham vardhippikkunnu.

