
sompirac

antipyretic pravarthanangalulla vaayiloode phalapradamaaya nonstiroyidal aanti-inflammatory marunnaan (enn. ezz. eiii. aii. dii) sompirac. 1980ll eph. dii. eiii. amgeekaricha mcneil farmaceuticals vikasippichedutha ithu somax enna brand naamatthil soodiyam salt sompirac sodiyamaayi vittu. klinikkal falaprapti kaaranam, pala saahacharyangalilum doctormar ithu ishtappedukayum vedanasamhaarikal vipaniyude valia punk nedukayum cheythu; ennirunnaalum, rogikalude janasamkhyayude cheruthum ennaal pravachanatheethavumaaya upavibhaagathil gurutharamaaya anaphylaxis undakkaanulla pravanatha kaaranam 1983 maarchil ithu pinvalikkapettu.
soochanakal.
neriyatho kadinamo aaya vedana niyantrikkaan somepirac soochippichu. onniladhikam klinikkal pareekshanangal aspirin allengil kodinekkaal kooduthal phalapradamaanennum codin allengil mattu opiyoyidukal adangiya vedanasamhaarikal pole phalapradamaanennum theliyichu. shasthrakriyaykk sheshamulla vedanayil morphinte saadhaarana intramuscular dosukalkku thaarathamyappeduthaavunna vedanasamhaarikal somepirakku nalki, deerghakaala upayogathiloode, athinte vedanasamhaarikalkku sahishnuthayo maanasikamo shaareerikamo aaya aashrithathvamo prakadippichitilla.
raasaghadana.
5-(4-chlorobenzoyil)-1,4 dimethyl-1 "echu"-pyrol-2-asattett dihydratinte soodiyam uppaan sompirac. tolmettinumaayi gadanaaparamaayi bandhappettirikkunna oru pyrol-asattik aasidaanit. central benzene valayathinu pakaram oru pyrol sthaapichathil raasaghadana mattu ensideukalil ninnu vyathyasthamaan.
pravartthana samvidaanam.
oru prostaglandin synthettes inhibittaraanu somepyrac.
anaphylaxis.
somepirakku nerittu anaphylaxis undaakkunnillengilum yuu. dii. pii-glucuronosil transferase (yuu. jii. tii) vazhi rasavinimayam nadatthi reactive glucuronida maattaanaavaathavidham plasma albumin bandhippikkunnu.
synthesis.
diethyl 1,3-asettonidaarboksilett, chloroasetton, aqvius methilaamain (menh2) ennivayil ninnu somepyrac samanvayippichu hantssh pyrol synthesis parishkkarichukondu intermediat 1 nalkaam. saponification, monoesterfication, thermal decarboxylation enniva esttar 2 nalkunnu. ithu "enn", "enn"-dimethyl-"pii"-chlorobenzamide upayogichu asailettu cheythirikkunnu, oduvil saponification somepyrac (3) nalkunnu.

