koksasaki koksasaki vairas

picornaviridae" kudumbatthilppetta enterovirusukalaanu koksasaki koksasaki vairas. eee virusukal lokamembaadum kaanapedunnu. avaa positteev sense, single-stranded, icosahedral jyamithiyulla noonn-enveloped rna virusukalaanu. koksasaakkivairasukalkk eiii, bii enningane rund grouppukalundu, oronnum vyathyastha rogangalumaayi bandhappettirikkunnu. coxasackivirus group eiii kaii-call-vaaya rogangalkk kaaranamaakumbol aarr serotypeukal adangiya group bii dahananaalathile vishamam myocarditis polulla vyathyastha lakshanangalkk kaaranamakum. coxasackivirus coxasackivirus swaabhaavika kolayali koshangalkkum pancreatic ailett koshangalkkumulla oru sell tropism undu. anubadha beetaa sell apoptosisilekku nayichekkaam, ithu insulittisinte saadhyatha vardhippikkunnu.
vairal ghadanayum genome.
group biyil kaanapedunna aarr serodypeukalil onnaanu coxasackivirus koksasaki, ithu oru positteev sense, single-stranded, noonn-enveloped rna vairasaanu. athinte genome rekheeyavum neelatthil 7,293 nucleodideukalullathum 5 ', 3' vivarthanam cheyyaatha pradeshavum athinte swantham 3 'poolii-eiii vaaline encode cheiyunnu. 5 'vivarthanam cheyyaatha pradeshathu oru aantharika ribosomal entry saitt (type i ires) adangiyirikkunnu. 5 'yuu. tii. aarumaayi sahavarthithvathode bandhippichirikkunna vairal protein vii. pii. jii vairal praveshanathinum replication sahayikkunnu. 2eiii, 2eiii enniva vairal proteinesukalaanu, ithu genome encode cheytha polyprotein pilaraan sahayikkunnu. sahayikkunnu ennathu rna-dependent rna polymerase (rdrp) aanu. aanu, protein, 3eiii enniva coor vairal proteinukalaanu. ekadesham 30 enm ulla vairal kanangalkk oru icosahedral capsid roopappeduthunna 4 capsid proteinukalaaya vipi 4, vipi 1, vipi 2, vipi 3 ennivaykkum genome coode cheiyunnu. vii. pii. 1-vii. pii. 3 aanu vairiyante puram uparithalathinu kaaranamaakunnath, athesamayam vii. pii. 4 capsidinullil ulchernnirikkunnu. 
mothatthil, coxasackivirus genome encode cheytha polyprotein ekadesham 2,200 amino aasidukal neelamullathaanu, oduvil 2a, 3c proteinukalum hoost sell proteinukalum ithu pilarunnu.
coxasackivirus koksasaki umm picornavirus kudumbatthile matellaa amgangalum pothinjathallaathathinaal, avaa anunashini, layakangal, kuranja piechu alavu (athaayath.iii. vayarile assid), kuranja thaapanila, 70 sathamaanam madyam.
vairal replication.
attaachment, entry, uncoating.
koksasaki vairasukalude capsidinu anchiratti achuthandinu chuttum verthirichariyaan kazhiyunna oru depression undu, ithine "kaanyon" ennu vilikkunnu.kosha uparithala thanmathrakalumaayulla prathipravartthanathiloode vairal attaachmentine sahaayikkumenn karuthappedunnu. (riyabi, 2014) hridaya peshikalude koshangalilum epithelial, endothelial koshangalilum kaanapedunna koksasaki-adenovirus resepterumaayi (kaar) (kaar) bandhippikkumbol, oru conformation maattam hoost sell resepterukale plasma membranile oru sushiramayi roopappeduthunnu, athiloode vpg-linked vairal genome koshatthilekku praveshikkaan kazhiyum. capsid plasma membranilekku vidukayum genome cytoplasathilekku kuthivaykkukayum cheiyunnathinaal uncoating anaavasyamaanu.
replication.
positteev sensinu, single-stranded rna virusukalkku, transcriptionu munbaanu vivarthanam nadakkunnathu. aathidheya koshatthinte cytoplasathilekku genome praveshikkumbol, 5 'yuu. tii. aarile airukal vivarthana prakriya aarambikkunna ribosomal subunitukale (cap-indipendant mechanism) niyamikkunnu. polypeptide poornnamaayum vivarthanam cheyyappettukazhinjaal, vairal proteinesukal 2eiii, 2eiii ennivayum sellular proteinesukal polyproteene vyakthigatha proteinukalaayi vibhajikkunnu, athu vairal replication prakriya thudaraan sahayikkum.
vairal proteinukal vivarthanam cheyyukayum pilarukayum cheythayudane, vairal genome negatteevu sense traanscriptukal kooduthal positteev sense vairal genome traanskripttukalkkulkal oru template varthikkunnu (ithu kooduthal vairal proteinukalaayi vivarthanam cheyyaan kazhiyunna emrna varthikkunnu). vairal genome oru poolii-eiii vaalinaayi encode cheiyunnu, ithu sellular iniishyeshan gadakangalum ribosomal sabyoonittukalum upayogichu thirichariyaan kazhiyum, ithu negatteevu-sense strand undakkaan transcription prakriya aarambikkukayum eratta-stranded rna intermediat roopappedukayum cheiyunnu.
negatteevu sense rnaude transcription cheyyumbol, kooduthal positteev sense rna genome undakkaan aarambhikkunnathin ithu primed cheyyendathundu. aarr. enn. eiii. genome 5 'attavumayi sahavarthithvathode bandhippichirikkunna vii. pii. jii proteinil 2 yuu. kall gadippichirikkunnu. vairal aarr. dii. aarr. pick thirichariyaan kazhiyunnathum negatteevu sensil ninnu kooduthal genome roopappeduthaan thudangunnathumaaya oru protein primeraayi pravartthikkunna vii. pii. jii proteinil maattam varuthuka ennathaanu eee yuu.-kalude uddeshyam.
vairal protein protein positteev sense rna genomeukal endoplasmic rettikulathilekku konduvarunnu, avide assembly pakwathayum sambhavikkum.
ithellaam sambhavikkumbol, vairal proteinesukal eee. aii. eph-4 iniishyeshan factor pilarthunnathiloode hoost sell protein synthesis oof cheyyaan pravartthikkunnu. hoost sell emrnakalumaayi bandhippikkunna ribosomukale eee prakriya thadayunnu. ithu hoost sellile cap-dependent translation phalapradamaayi nirtthunnu.
assembly, pakwata, egrez.
vairal genome, vairal proteinukal enniva aathidheya koshatthinullil vendathra uyarnna saandrathayil ethiyaal, gadanaaparamaaya proteinukal kootticherkkanam. vairasinte pakwathayude avasana ghattam, oru mungamiyaaya proteinaaya vii. pii. 0, vii. pii. 2, vii. pii. 4 ennivayaayi vibhajikkappedumbozhaanu. vairal capsid proteinukal orumichu pentaamarukal roopappeduthunnu, avayil 12 ennam orumichu oru shoonyamaaya capsid allengil procapsid (exacy, hund, 2010) roopappeduthunnu.
neratthe soochippichathupole, vairal protein protein sii. bii. 4 vairal genome vesicle roopeekaranam aarambikkunna endoplasmic rettikulathilekku konduvarunnu. err membran genome, protein ennivaykku chuttum neengunnu, eee samayat procapsid vesikkilinte purambhaagathu gadippikkukayum genome, protein enniva ulkkollukayum cheiyunnu. eee ghattathilaanu ghattathilaanu oru sellular proteinase vazhi pilarukayum vairas oduvil poornnamaayum pakwata praapikkukayum pakarchavyaadhiyaavukayum cheiyunnathu. sii. bii. 4 oru moodaatha vairasaayathinaal, ithu cytolysisiloode puratthekku pookunnu, hosttile mattu koshangale baadhikkunnathinaayi plasma membraniloode thakarkkunnu (vetta, 2010)
lakshanagal.
koksasaki bii 1-4 virusukalaanu saadhaaranayaayi ettavum kadinavum maarakavumaya navajatharogangal. myocarditis, meningoensephalitis, heppattaitis enniva saadhaarana lakshanangalil ulppedaam. pneumonia, dahananaala lakshanagal, pancreatitis, apasmaram enniva gurutharamallatha mattu lakshanangalil ulppedaam. koksasaki koksasaki vairas ulla rogikalkku herpanjina, tonsilitis, faaranjittis ennivayundennu thonnunnu.
thonnunnu vairas elikalil traansplaasental anubaadhakalkk kaaranamaayi. garbhaavasthayude aadya randaazhchayile anubadha anakalkkum garbhapindathinum doshakaramaanennu theliyikkappettittund, ithu maalinyathinte valuppam kuraykkunnathino garbhachhidram allengil mrithajanmam ennivaykku kaaranamaakunnu. garbhaavasthayude 4,17 divasangalil anubaadhayetta daamukalil ninnu janicha naaykkuttikalkku ganyamaayi (pii <0.05) kooduthal pancreatic asaadhaaranathakal undaayirunnu, ithu pramehathinu samanamaaya lakshanangalilekku nayikkunnu.
koksasaki koksasaki viruses type 1 pramehavum.
type 1 prameham vairas-trigger cheytha svayam rogaprathirodha prathikaranamaanennu oru sidhaantham nirddeshikkunnu, athil rogaprathirodha samvidaanam paankriyaasile beetaa sellukalkkoppam vairas baadhicha koshangaleyum akramikkunnu, ennaal innuvare eee sidhaanthathe pinthunaykkunnathinu karsanamaaya thelivukalonnumilla.
coxasackivirus bii anubadhayum type 1 pramehavum thammilulla saadhyamaaya bandham vishakalanam cheiyunna 2004 leeii chittayaya avalokanam anishchithathvathilaayirunnu. 2011 leeii chittayaya avalokanavum mettaa vishakalanavum enterovirus anubadhayum type 1 pramehavum thammilulla bandham kaanichu, ennaal ithinu vipareethamaayi, mattu padanangal kaanikkunnath oru svayam rogaprathirodha prakriyaykku kaaranamakunnathinupakaram, coxasackivirus bii enna enterovirus anubaadhaykk type 1 pramehatthinte thudakkathilum vikaasathilum ninnu samrakshikkaan kazhiyumennu.
navajaathashishukkalilekk kaimaattam.
enterovirusukal saadhaaranayaayi navajaathashishukkaleyum 12 maasathil thaazheyulla sisukkaleyum badhikkunnu. koksasaki bii virusukal saadhaaranayaayi prasavasamayatthe pakarchavyaadhiyiloode sisukkalilekku vyaapikkunnu. ennirunnaalum, koksasaki bii vairasukalude kooduthal gurutharamaaya kesukal traansplaasental traansmissioniloodeyaanu padarunnathu. kuttikalil navjata koksasaki bii vairas anubaadhayude saadhaarana lakshanangalil meninchaitis koodaathe/allengil encephalitis ulppedunnu. koksasaki koksasaki vairasinu thalachorineyum sushumna nady badhikkaanum veekkam undakkaanum kazhiyum.
roganirnayam.
koksasaki bii virusukal moolamundaakunna anubadha rakthathile neutralising aantibodikalude alavu alakkunnathiloodeyum pcr, microscopic kandethaliloodeyum nirnnayikkaan kazhiyum. rogalakshanangalude adisthaanathil sii. bii. vii. nirnnayikkaan prayaasamaan.

