tack-653

chikitsa prathirodhikkunna vishaadathinulla chikilsayaayi anweshikkunna oru pareekshanathmaka marunnaan tack-653. takeda (millennium farmaceuticals, ink.).
pravartthana samvidaanam.
aampa resepterinte selective positteev alosteric modulettaraanu tack-653. tack-653 umm mattu positteev alosteric modulettarukalum resepterinte samvedanakshamatha kuraykkalinteyum aantharikavalkkaranathinteya nirakk mandagathiyilaakkikkondu aamba resepterinte pradhana saittil agonist bindinginte pravartthanangal shakthippeduthunnu.
aantidiprasant gaveshanam.
kettaamain polulla enmdi risapttar aantaagonistukalude aantidiprasant efakttukalude kendramaanu aamba resepterinte sajeevamaakkal, emtiaarinte downstream sajeevamaakkal, bdnfinte appregulation enniva ennu soochippikkunna thelivukal undu. aampa resepterinte thadassam kettaamaininte aanti-depressant pravartthanatthe illaathaakkunnu. aampa resepteril endogenous glutamettinte prabhavam shakthippeduthunnathiloodu, tack-653 aampa risapttar-mediated transcriptione kooduthal nerittu swaadheenikkunnu.
tack-653 oru noonn-psychotomemetic aayi upayogikkaan saadhyathayulla (orupakshe enmda athiraalikalude pravartthanatthinte abhavam kaaranam) athinte anweshanathinu kaaranamaayi udharikkappedunnu. kettaamainil ninnu vyathyasthamayi tack-653 elikalil hyperlocomoter prathikaranangalkk kaaranamaakunnillenn praadhamika gaveshanangal kandethi. ennirunnaalum, tack-653-nte sii. enn. ezz uttejaka gunangalum sahishnutayum anweshikkunna oru manushya pareekshanam, marunninte sii. enn. ezz uttejaka gunangal mattu cycostimulantukale apekshichu kuravaanengilum, tack-653-nuu chila uttejaka phalangalenkilum undennu report cheythu. vichaaranaykkide gurutharamaaya prathikoola phalangalonnum kandethiyitla.
aampa risapttar agonistukal klinikkal aaplikkeshanukalkku praayogikamalla, kaaranam avaa avarude chikitsa jaalakathin sameepamulla dosukalil pidichedukkalukalum amithamaya uthejanam moolamundaakunna neurotoxisityum undakkaanulla saadhyathayaanu. tack-653 nuu nerittulla aampa agonist gunangal kuravaanu. tack-653 elikalile chikitsa dosukale apekshichu virayalukalkethire 419 madangu suraksha marjin nalkunnu.

