
amine alchylation

alkail hallide amonia allengil amain thammilulla oru tharam jaiva prathikaranamaanu amine alchylation (amino-dehalogenation). eee prathikaranatthe nucleophilic aliphatic substitution (halaidinte) ennum prathikarana uthppannam uyarnna pakarakkaranaaya amine ennum vilikkunnu. eee reethi laboratariyil vyaapakamaayi upayogikkunnu, pakshe vyaavasaayikamaayi athra kuravaanu, avide alcoholeukal palappozhum alkailetting ejantumaaraanu.
aminukalum amonia saadhaaranayaayi neraaya alchylation vidheyamaakkaan mathiyaya nucleophilic aanu, palappozhum mithamaaya avasthakalil. alkailetting ejantumaayi prathipravarthikkaanulla uthppannathinte (oru praadhamika amine allengil oru dvitheeya amine) pravanathayaanu prathikaranangal sankeernamaakkunnathu. udaaharanathinu, amoniayumaayulla 1-bromoctainte prathikaranam praadhamika amaininteyum dvitheeya amaininteyum eathaandu thulya alavil nalkunnu. athinaal, laborattari aavasyangalkkaayi, "n"-alchylation palappozhum thritheeya aminukalude samanvayathil parimithappedutthiyirikku. praadhamika aminukale amoniayumaayi samanvayippikkaan anuvadikkunna alfa-haalo carboxylic aasidukalude amineekaranamaanu oru apavaadam. haloamines x-(ch2) "n"-nh2-nte intramolecular prathikaranangal chaakrika asiridinukal, asettidinukal, pyrolidinukal enniva nalkunnu.
"n"-alchylation ennathu thritheeya aminukalil ninnulla kwaattenari amonium lavanangalilekkulla pothuvayathum upayogapradavumaaya oru maargamaan, kaaranam ovaraalkkaileshan saadhyamalla.
benzylaniline, 1-benzylindol, assettidin ennivayude samanvayamaanu alkail halaidukalumaayulla enn-aalkkaileshante udaaharanagal. saiklante derivatisationil mattoru udaaharanam kaanapedunnu. vyaavasaayikamaayi, amonia 1,2-dichloro eedheynumaayi alchylation cheiyunnathiloodeyaanu ethylenediamine uthppaadippikkunnathu.
anilyn, anubandha aril derivateevukal.
parambaraagathamaayi, naitro grouppukal oortho allengil paara polulla sakthamaaya electron-valikkunna grooppukalullava polulla "sajeeva" aaril haalaidukal saadhaaranayaayi aavasyamulla budhimuttulla prathikaranamaanu aaril amination. nirjjeevamaakkaatha aaril haalaidukal upayogichu amainukalude arileshanu, bookwald-hartwig prathikaranam upayogapradamaanu. eee prakriyayil, paladium samuchayangal kaattalistukalaayi pravartthikkunnu.
alcoholeukal upayogichu alchylation.
vyaavasaayikamaayi, mikka aalkkaileshanukalum saadhaaranayaayi alkail haalaidukalalla, alcoholukalaanu upayogikkunnathu. alcoholukalkku alkail haalaidukalekkaal vila kuravaanu, avayude alchylation lavanangal ulppaadippikkunnilla, avayude nirmarjanam prasnakaramaanu. hydroxyl groupine oru nalla leaving grooppaakkunna kaattalistukalude upayogamaanu aalkkaholukalude aalkkaileshante thacol. amonia, methanol ennivayil ninnulla methilaamain ulppaadanamaanu ettavum valia skeyil "enn"-alchylation, athinte falamaayi ekadesham 500,000 tonn/vaii methilaamain, dimethylamine, trimethylamine enniva undaakunnu. prathikaranam moshamaayi thiranjedukkappettathaanu, moonnu uthppannangalum verthirikkendathundu. vyaavasaayikamaayi praadhaanyamulla mattu niravadhi alkail aminukal veendum valia thothil alcoholukalil ninnu uthppaadippikkappedunnu. ethanolamine uthppaadanathinu upayogapradamaaya halide rahita "enn"-alkailetting ejantumaarude mattoru vibhagamaanu epoxideukal.
badal alchylation reethikal.
laborattari upayogathinaayi, "enn"-alchylation prathikaranam palappozhum thiranjedukkappedaathaana. hexamine upayogikkunna delepine prathikaranam polulla vividha badal reethikal vikasippicheduthittundu. enh2− nuu thulyamaaya upayogam ulppedunna gabriel synthesis praadhamika alkail haalaidukalkk maathrame baadhakamaakoo.