
lqhit2

leurus quinquestriates hebreyasil" ninnu uruthirinja oru neelamulla shringhala thel depressant β-toxinaanu elkhittu 2. ithu praanikalude volteju-gated soodiyam chaanalukale (enn. eiii. vii. ezz) lakshyamidukayum chaanal aakttiveshante volteju aashrithathvathe kooduthal negatteevu membran pottanshyalilekku maattukayum cheiyunnu.
kudumbavum ghadanayum.
neelamulla shringhala thel depressant β-toxinukalude kudumbatthil pedunna onnaanu lqhit2. iii upayogichu protein ulppaadippikkaam. koolii. 
6. 4 enna aiso electric pooyintulla elkhittu 2-nte tanmatra pindam ekadesham 5 keey. dii. eiii aanu. elkhittu 2 thaarathamyena cheria proteinaan, athil 61 amino aasidukal maathrame adangiyittulloo. protein oru neenda shringalayilulla vishavasthuvaan, athaayath ithu moonnu-stranded aantipaaralal β-sheettukalil paaykk cheythirikkunna oru α-helix kondaanu nirmmichirikkunnathu. motham naalu sisttain sulfide paalangal eee nirmmaanatthe sthirappeduthunnu. 
α-helix, β-sheettukal ennivayaanu coor globule nirmmikkunnath. eee coor globule ensie-globuleumaayi bandhippichirikkunnu, ithu oru vashath enn-grove maruvashathu sii-grove kondu chuttappettirikkunnu. elkhithu 2-nte shakti, pravartthanam, thiranjedukkal ennivaykku enn-grove pradhaanamaan.
elkhittu 2-nte vishaamshathin praadhaanyamundennu karuthappedunna kurachu amino aasidukal undu sii-terminasil avasheshikkunna asn 58, gly 61, koodaathe athinte aduthulla bio active uparithalathil asp 8, lies 11, lies 26 enniva.
lakshyam.
volteju sensor s3-s4 upayogichu membran pottensialile maattam volteju ashrita soodiyam chaanalukal kandethunnu. voltejile maattam oru aakshan pottanshyalinte paridhi athumbol, ayoon chaanal thurakkukayum soodiyam ionukal koshatthilekku vyaapikkukayum cheiyunnu. thel β-toxinukalude pothuvaaya lakshyam naavukalude risapttar saitt 4 aanu. thel depressant β-thel vishavasthukkalkk praanikalude naavukalodu uyarnna aduppamundu.
elkhittu2 toxin rund noonn-interacting binding sittukal undu uyarnna affinityum kuranja sheshiyulla binding saittum athupole kuranja affinityum uyarnna sheshiyulla binding saittum. volteju gated soodiyam chaanalinte risapttar saitt 4-lake lqhit2 bandhippikkunnu, kooduthal vyakthamaayi d2/d3-s Â lupe cheyyaan. koodaathe, vishavasthukkal phospholipid bilayerumaayi prathyekamaayi bandhippikkathe kosha stharathilekku vibhajikkunnu. ennirunnaalum, risapttar saitt 4-lekkulla bindinginekkaal pathuvattam saavadhaanathilaanu eee binding sambhavikkunnath.
pravartthana reethi.
naavukalude risapttar saitt 4-lake bandhippicha sesham, chaanalinte aaktiveshan threashold kooduthal hyperpolarised membran pottanshyalilekku maarunnu. sajeevamaakkal paridhiyile eee maattam rund gattangalulla prakriya moolamaanu. 
aadyam, chaanalukalude nilavile avastha pariganikkathe vishavasthukkal navs chaanalinte ezz3/ezz4 binding saittumaayi bandhippikkunnu. chaanal thuranna avasthayilekku maariyukazhinjal, toxin aaktiveshan censorine athinte nilavile sthaanathu keniyil pedutthunnu, angane ayoon chaanal thurakkaan eluppamaakkunnu. chaanal ippol pree activated avasthayilaanu. chaanal oru preactivated avasthayilekku maattunnathiloode, elkhittu 2 toxin swaabhaavika neuro traansmittar release nirakk vardhippikkunnu. 
aduthathaayi, traansmittarinte vardhicha nirakkine thudarnnu synaptic pottanshyalukal kurayukayum oduvil neuro muscular transmission block undaakukayum cheiyunnu. prayogichathinu sesham 3 minittinullil, navs pravartthanatthe adisthaanamaakkiyulla synaptic signalukalude amplitude vishavasthukkal kuraykkunnu. ithu aakshan pottanshyalukalude aamplityoodil kramena kuravundaakunnathilekku nayikkunnu. 4 minittinusesham, sell sthiramaaya depolarisation avasthayilaanu, ithu kooduthal aakshan pottanshyalukalude uthpaadanathe thadayunnu. 
vishaamsham.
100 milligram shareerabhaarathil 50 enji elkhithu 2 kuthivayppu bloefly laarvakale thalarthaan paryaapthamaan. eee kuthivayppu prayogichathinu sesham eathaanum sekkantukalkk sesham oru hrasvamaaya shanikamaaya peshi sankochathinu kaaranamaakunnu. ennirunnaalum, peshi vaidyuthaparamaayi uthejippikkappedunna membran pottensial vardhippikkunnathinulla paridhi kurayunnu. kuthivayppinu sesham anchu minitt vare neendunilkkunna flaxid pakshaaghaatham eee sankochathe pinthudarunnu. navs chaanalukalude prarambha vardhicha samvedanakshamathayum neuro traansmittarinte anantharafalamaayulla prakashanavum kedukoodaattha laarvakalile hrasvamaaya churungal ghattavumayi bandhappettirikkunnu. thudarnnulla synaptic saadhyathakalude kuravu flaxid pakshaaghaathatthinte thudakkathinu kaaranamaayekkam. 
elikaleppolulla sasthanikalkk eee vishavasthukkal vishamaanenn thonnunnilla.
paraamarshangal.
 

