
chemerin

retinoic assid risapttar responder protein 2 (rarez 2), tasarottin-induced jeane 2 protein (taig 2), allengil raara-responsive protein taig 2 ennum ariyappedunna chemerin manushyaril "rarez 2" jeane encode cheiyunna oru proteinaan.
pravartthanam.
retinoyidukal sakthamaaya valarchaa prathirodha, kosha vyathyasa pravartthanangal polulla jaiva efakttukal cheluthunnu, avaa hyperproliferative dermatological rogangalude chikilsayil upayogikkunnu. transcription regulettarmaarude steroid, thyroid hormon risapttar suuppar faamiliyile amgangalaaya nirddishta nuclear risapttar proteinukalaanu eee efakttukalkku madhyasthatha vahikkunnath. synthetic retinoid tasarottin upayogichu expression niyanthrikkunna jeenukalaanu rarez 1, rarez 2 (eee jeane), rarez 3 enniva. rarez 2 oru sell uparithala resepteraayi pravarthikkunnathaayi karuthappedunnu.
jii protein-cuppled risapttar sii. emm. keey. ell. aarr. 1 (kemar 23 ennum ariyappedunnu)-nte ligandaayi pravartthikkunna oru keemoaatraktant proteinaan chemerin. prochemerin enna nilayil nishkriyamaaya roopathil sravikkunna 14 keey. dii. eiii proteinaan chemerin, koshajwalanavum kattapidikkunnathumaaya serin proteasukal vazhi sii-terminasinte pilarppiloode ithu sajeevamaakunnu.
veekkam sambhavikkunna sthalathekku dendraitik koshangaludeyum macrophageukaludeyum chemotaxis uthejippikkunnathinu chemerin kandethiyittundu.
manushyaril, chemerin marnah velutha adipose tissue, karal, shwaasakosham ennivayil valareyadhikam prakadippikkappedunnu, athesamayam athinte risapttar, cmklr 1 pradhaanamaayum rogaprathirodha koshangalilum adipose tissuevilum prakadippikkunnu. adiposite deferentiationilum glucose ettedukkalilum chemerin vahikkunna punk kaaranam athine adipokkin aayi tharamthirickunnu.
oru adipokkin enna nilayil.
adiposite deferentiation lippolisisinte uthejanathinumulla autocrine/paracrine signalingil chemerin ulppettittund. 3t3-l1 koshangalumayulla padanangal kaanikkunnath chemerin expression pree-deferentiated adiposaittukalil kuravaanennum ennaal "inn vitro" deferentiation samayat athinusheshavum athinte expression sravavum vardhikkunnuvennum kaanikkunnu. chemerin allengil athinte risapttar, cmklr 1 ennivayude janithaka naakkdoun adipposaittukalilekkul vyathyaasathe thadassappeduthukayum glute 4, adiponectin ennivayude aavishkaaram kuraykkukayum cheiyunnu, athesamayam ail-6, insulin risapttar ennivayude aavishkaaram vardhippikkunnu. koodaathe, chemerinte vyathyaasathin sheshamulla nokkdaun glute 4, lepttin, adiponectin, perilippin, lipolysis enniva kuraykkunnu, ithu pakwathayulla adipposaittukalude upapachayam pravartthikkunnathil chemerin oru punk vahikkunnuvennu soochippikkunnu. pakwathayulla manushya adipposaittukal, 3t3-l1 koshangal, elikalil "inn vivo" padanangal enniva upayogichulla padanangal kaanikkunnath lipolysisinu madhyasthatha vahikkunna maappukal, erc 1, erc 2 ennivayude phosphorilatione chemerin uthejippikkunnu ennaanu.
elikalil nadatthiya padanangal kaanikkunnath braun adipose tissuevil chemerin allengil cmklr 1 enniva uyarnna thothil prakadippikkunnillenna, ithu soochippikkunnathu oorjja sambharanathil chemerin oru punk vahikkunnu ennaanu.
ponnathadiyilum pramehathilum punk vahikkunnu.
oru keemoaatraktant enna nilayil chemerinte pankum aduthide kandethiya macrophageukalum ponnathadiyile adipose tissuevinte vittumaaraatha veekkathinu kaaranamaakunnu. ponnathadiyudeyum insulin prathirodhatthinteyum rogakaarikalil chemerin oru pradhana punk vahikkumennu ithu soochippikkunnu.
elikalil nadatthiya padanangal elikalkku uyarnna kozhuppu adangiya bhakshanam nalkunnathu chemerin, cmklr 1 ennivayude prakadanatthil vardhanavinu kaaranamaayathaayi kandethi. manushyaril, saadhaarana glucose sahishnuthayulla vyakthikalum type II pramehavum phastt digri bandhukkalumulla vyakthikalum thammil chemerin alavu ganyamaayi vyathyaasappettirikkunnu. koodaathe, body maas indux, plasma triglyceride alavu, rakthasammardham ennivayumaayi chemerin alavu ganyamaaya parasparabandham kaanikkunnu.
recombinent human chemerin protein upayogichu 3t3-l1 koshangalude incubation insulin-uthejippicha glucose ettedukkal sugamamaakkiyathaayi kandethi. insulin censitivityil chemerin oru punk vahikkunnuvennum type II pramehathe chikilsikkunnathinulla chikitsa lakshyamaayirikkamennum ithu soochippikkunnu.

