
click 5

chloride intra sellular chaanal protein 5 manushyaril "click 5" jeane encode cheiyunna oru proteinaan.
aavishkaaravum praadeshikavalkkaranavum.
click 5 rund badal splies vakabhedangalil nilavilundu, oru cheria click 5 eiii, valia click 5 bii protein.
klinik5eiii pradhaanamaayum vrukkasambandhiyaaya glomerulasil, prathyekichu podocytukalil prakadippikkunnu. koshatthinullil, click5eiii plasma membranilekkum cytosolilekkum praadeshikavalkkarikkuppudu aaktin cytoskelittan niyanthrikkukayum cheiyunnu. click5eiiiykku inn vitroyil ayoon chaanalukal roopappeduthaan kazhiyum, athinte chaanal pravartthanam aaktin niyanthrikkunnu, ennirunnaalum athinte chloride chaalakathayude alavu "inn vitro" soochippikkunnathu click5eiii kattiyanukalkkum ionukalkkum thulyamaayi thiranjedukkappettathaanne soochippikkunnu. ennirunnaalum, bonafied ayoon chaanalukal enna nilayil kliksinte pravartthanam vivaadaparavum tharkkavishayavumaan.
pravartthanam.
chloride intra sellular chaanal (click) proteinukal subsellular compartmentukalile ayoon gathaagathathil ulppettirikkunnuvennu karuthappedunnundengilum, avayude yadhaartha pravartthanangal click 1 leeii apoptosis, angiogenesis ennivayulppede vaividhyamaarnna sellular, physiological pravarthanangalil avayude punk soochippikkunnu.
click5eiii, cheria jidipes raaku 1-maayi athinte edapedalukaliloode, ezrin-moisin-radixin (erm) proteinukalude phosphorilation phosphoinsitide phosphaattidilinosittol-4,500-bisfosphettinte praadeshika ulppaadanavum prerippikkunnu. eee rund sambhavangalum ezrin sajeevamaakkukayum transmembrane proteinukale aaktin cytoskelitanilekku bandhippikkaan praapthamaakkukayum cheiyunnu, ithu vrukkakalude shudheekaranam praapthamaakkunnathin podosaitt phoott prakriyakal roopappedunna oru samvidaanathe prathinideekarikkum.
klinikkal prasakthi.
motham 5 perkku rogam baadhicha rund manushya kudumbangalkk pravartthanam nashtamayathaayi report cheyyappettittund. click 5-nte kuravu randaam dashakathode purogamanaparamaaya kelvikkuravu, westibular asaadhaaranathakal, vrukkayude pravartthanam ennivaykku kaaranamaakunnu.
mouse modalukalile click5eiiiyude kuravu hypertensionil glomerular parikkukalkk kaaranamaakunnu. eee elikalil, podosaitt call prakriyakalum vanyamaaya elikale apekshichu kooduthal viralavum chitharikkidakkunnathumaayinnu.

