
hyde1eiii

hypoglycemia/hypoxia inducble mitocondrial protein 1-eiii (hep 1-eiii) ennum hypoxia induced jeane 1 (haiga 1 eiii) ennum ariyappedunna hyglycemia/hypoxia famili memper 1 eiii (haigdi 1 eiii), manushyaril chromosome 3 leeii "haigdi 1 eiii" jeane encode cheiyunna oru proteinaan. eee protein mitocondrial homeostasisineyum sammarddathilulla koshangalude athijeevanatheyum prothsaahippikkunnu, koodaathe rakthapravaham, hypoxia ennivayumaayi bandhapetta rogangalil earppedunnu, athil etherosclerosis, ischemic hrudrogam, alshimezhs rogam, cancer ennivayulppedunnu.
ghadana.
eee jeane encode cheytha protein 10.4 kiloo dii. eiii. mitocondrial innar membran proteinaan, enn-sii-terminalukalil rund transmembran domainukalundu. eee rund domainukalum krameekarichirikkunnathu enn-sii-terminalukal intermembran speysilekku puratthekku abhimukeekarikkumbol bakkiyulla protein looppukal matrixinullil athunnu. hyde1eiiiyude praadeshikavalkkaranathinu enn-terminal domaine aavashyamillengilum, proteente nilanilppin ithu aavasyamaanu.
badal spliesing vazhi "hemp 1-bii" yude oru isophomaanu "higd 1 eiii" jeane.
pravartthanam.
hypoxia, glucose abhavam thudangiya sammarda saahacharyangalil koshangalude athijeevanam, hydocondrial homeostaasisilaanu haig 1 eiii praadhamikamaayi pravartthikkunnathu. udaaharanathinu, haig 1 eiii sammarddathil pancreatic α, β koshangalude athijeevanathe prothsaahippikkunnu. thalachorinte mattu bhagangal, hridayam, karal, vrukka ennivayil eee avayavangalude nilanilpp vardhippikkunnathil ninnu hyde1eiii kandethiyittundu. macrophageukalil, haigd1eiii cytochrome sii release caspace pravartthanavum thadayunnathiloode apoptosis thadayunnu.
opaa 1 pravartthanam niyanthrikkunnathiloode mitocondrial fusionilum hyde 1 eiii ulppedunnu. opaa 1-nte pilarpp thadayunnathu mitocondrial membran pottensial samrakshikkukayum apoptosisine prathirodhikkukayum eiii. tii. pii nila nilanirthukayum cheiyunnu. mitocondrial fusionile athinte punk emm. tii. dii. enn. synthesis, koshavalarcha, kristte oorganaiseshan thudangiya thaazhekkulla prakriyakaleyum swaadheenikkunnu.
koodaathe, hypoxic saahacharyangalil mitocondrial γ-srava pravartthanam niyanthrikkunnathiloode mitocondrial pravartthanam samrakshikkaan highged 1eiii sahayikkunnu. hyde1eiiiyude abhaavathil, maittokondriyayil amyloid beetta adinjukoodunnathinu γ-sravangal kaaranamaakunnu, ithu rooss uthppaadanam vardhippikkunnathinum mitocondrial pravarthanarahithamaakkunnathum oduvil koshangalude maranathinum kaaranamaakunnu.
hyde1eiii pradhaanamaayum koshangalude nilanilppin sambhavana cheyyumbol, kendra naadeevyavasthayude prarambha vikasana ghattangalil neuronukalil apoptosis prolsaahippikkaanum ithinu kazhiyum.
klinikkal praadhaanyam.
hypoxyayude keezhil hydie1eiii koshangalude athijeevanathe prolsaahippikkunnathil, protein hypoxyayumaayi bandhapetta rogangalil ninnu hridayavum thalachorum polulla avayavangale samrakshikkunnu. prathyekichum, nucleusilekkulla hydie1eiii praadeshikavalkkaranam ischemic hrudrogam, hypoxic-ischemic encephalopathy, cancer ennivayile sammarddathinte theevrathayumaayi bandhappettirikkunnu, athinaal eee rogangalkk oru biomarkeraayi varthikkaam. koodaathe, haig 1 eiii macrophage athijeevanathil athinte pankiloode rakthapravaham, rheumatoid aarthraitis thudangiya koshajwalana rogangalil earppedunnu. athupole, γ-sravathe thadayunnathiloodeyum vipuleekaranathiloode amyloid beetta ulppaadanathiloodeyum alsheimer rogathe chikilsikkunnathinulla oru pradhana lakshyamaayi higd1eiii maarum. prathyekichu, hyde1eiii nochu villalumaayi edapedaathe γ-sravathe thadayunnu, angane eee proteine lakshyamidunnathil ninnulla doshakaramaaya paarshwafalangal kuraykkunnu.
ashayavinimayam.
hyde1eiii ivayumaayi samvadikkunnathaayi ariyappedunnu