garbhadharanam

projestroninte nishkriyamaaya upapachayam ulppannamaanu garbhakalarogam allengil 5β-pregnain-3α, 20α-diol. moothrathile garbhakaalathe alavu alakkaan oru parisodhana nadatthaam, ithu shareerathile projestroninte alavu alakkunnathinulla paroksha maarggam vaagdaanam cheiyunnu.
lunden klinikkukalil ninnulla garbhinikalude moothrathil ninnu, rund hydroxyl grouppukal adangiyathum asattik anhydride upayogichu diasettettaayi parivartthanam cheyyaavunnathumaaya oru padaarthatthe geyy frederic marian verthirichu. ennaal, formula vyakthamaayi vyakthamakkiyittilla. eathaandu athe samayam, gottinganile kemikkal yooniversitti laborattariyile adolph beautnand garbhiniyaya moothrathinte gadakangal parisodhikkukayum diolinte ghadana vyakthamaakkukayum cheythu. beautenand srishticha garbhadharanam enna peru laattin kriyayaya pragnance (garbhini, garbhini) allengil engleesh garbhiniyum garbhadhaaranavum ennathil ninnaan uruthirinjathu. ithu adisthaana maathru hydrocarboninu garbhadharanam enna peru nalki. 
1936-ll, venning brounum garbhakala moothrathil garbhakala moothrathinte, prathyekichu garbhakala moothrathinte glucuronidinte saannidhyam pradharshippichu. avarude patanam garbhaavasthayile moothrathil ninnu garbhakaalathe moothrathil ninnu verthirichedukkukayum moothrathile garbhakaalathe moothrathinte saandrata puranthallappedunna projestroninte alavu soochippikkunnuvennu velippeduthukayum cheythu. projestroninte alavu oru corpus leutiyathinte pravartthanatthe soochippikkunnathinaal, garbhakaalathe saandrata puranthallappedunna projestroninte <aii. dii. 1> prathinidheekarikkunnathil, garbhakaalathe kanakkukal oru corpus leutiyathinte pravartthanam velippeduthunnu. ennirunnaalum, aarthavachakra gattangalkkanusarichu garbhakala saandrata vyathyaasappedunnu, athinaal avaa parishodhikkumbol aarthavachakra ghattam pariganikkendathu athyaavasyamaanu. koodaathe, moothrathile garbhakala saandrathayum andashaya pravartthanatthinte alavaanennu nilavile gaveshanangal theliyichittundu.

