
sup1eiii

Ets domaine ennu vilikkunna oru advitheeya dna binding domaine adangiyirikkunna proteinukalude oru kudumbamaanu SAP1a.
transcription.
sapp1eiiiyude transcriptional aaktiveshan domaine sii-terminal mekhalayilaanu, athinte pravartthanatthe enn-terminus thadassappeduthiyekkaam. saap1eiiiyude sii-terminal mekhalaykkullile niravadhi saadhyathayulla erc samavaaya saittukalkk athinte traansaaktiveshan falaprapti krameekarikkaan kazhiyum, ithu saap1eiii erkkukalude nerittulla lakshyamaanennu soochippikkunnu.
ashayavinimayam.
serem prathikarana ghadakam recruitment cheyyumbol sii-phoos serem prathikarana gadakavumaayi sapp1eiii edapedunnathaayi thelinjittundu.
sii-phoos serem prathikarana ghadakam vazhiyum koodaathe serem prathikarana gadakathil ninnu swathanthramaayi oru iii. tii. ezz binding saitt vazhiyum uthejippikkunna oru nuclear proteinaan sapp1eiii.
phosphorylated sapp 1 eiii madhyasthatha vahikkunna oru prakriyayil insulin human insig 2 promotere sajeevamakki.
erkkukal vazhi sapp1eiii kaaryakshamamaayi phosphorylate cheyyappedunnu, pakshe sack/jnkal vazhiyalla. serem prathikarana ghadakam-ashrita trirashtra sankeernna roopeekaranam erc phosphorylation vazhi uthejippikkappedunnu, pakshe sapke/jnkukalalla. koodaathe, sapp1eiii-mediated transcription sajeevamaakkunnath mitogenic signalukaliloodeyaanu, pakshe kosha sammarddathiloodeyalla.
elk 1, sapp 1 eiii enniva sii-phoos promoteril sthithicheyyunna serem prathikarana gadakangalil (sre) srf ulla tritala samuchayangal roopappeduthunnathaayi kaanichittundu. elk1, sapla, fly1, iii. dablyu. ezz-fly1 ennivaykku iii. jii. aarr1 ezz. aarr. iii. yill ezz. aarr. eph upayogichu tritala samuchayangal roopappeduthaan kazhiyum. koodaathe, elk 1, sapp 1 eiii ennivaykku egr 1 sreyil kwaattenari complexukal roopeekarikkaanum kazhiyum.
klinikkal praadhaanyam.
extra sellular stimulikale nuclear prathikaranamakki maattunnathil erc vazhi SAP1a aaktiveshan oru pradhana punk vahichekkaam.