
prathyulppaadana-koshachakra sidhaantham

prathyulppaadana-koshachakra sidhaantham, prathyulppaadanathe niyanthrikkunna hormonukal koshachakra signalingiloode vaardhakyathe niyanthrikkunnathin virudhamaaya pleotrophic reethiyil pravarthikkunnuvennu abhipraayappedunnu; prathyulppaadanam nedunnathinaayi jeevithathinte thudakkathil valarchayum vikaasavum prothsaahippikkunnu, ennaal jeevithathil pinneedu, prathyulppaadanam nilanirthaanulla oru vyarthamaaya shramathil, aniyanthrithamaakukayum vaardhakyathe nayikkukayum cheiyunnu. vaardhakyam ennathu praayamaakumbol pravarthanakshamatha nashtappedunnathaayi kaanunnathinupakaram, eee sidhaantham vaardhakyathe nirvachikkunnath kaalakramena oru jeevajaalathile eathu maattavum aanu, shareerathile ellah raasapravarthanangalum nirthalaakkiyaal oru maattavum undaakilla enna vasthuthayude thelivaanu, athinaal vaardhakyam sambhavikkilla. kaalakramena oru jeevajaalathile ettavum pradhanappetta maattam oru koshatthe oru multisellular jeeviyaayi vikasippikkunna rasapravarthanangalaayathinaal, koshangalude valarcha, vikasanam, maranam enniva niyanthrikkunna eee raasapravarthanangale niyanthrikkunnathenthum vaardhakyathe niyanthrikkumenn vishwasikkappedunnu. eee sellular mattangal hypothalamic-pityoottari-gonadal aaksisinte (echpiji axis) prathyulpaadana hormonukaliloodeyaanu nayikkunnathenn sidhaantham vaadikkunnu. prathyulpaadana hormonukalkkaayulla resepterukal (eestrajan, projastojan, androjan, gonadotropin enniva polullava) shareerathinte ellah koshangalilum undennu kandethiyittundu. athinaal, echpiji axis hormonukal saadhaaranayaayi prathyulppaadanam nedunnathinaayi jeevithathinte thudakkathil thanne jeeviyude valarchayum vikaasavum prothsaahippikkunnu. aarthavaviraamathil athumbol 30 vayass praayamulla purushanmaaril hormonukalude alavu marran thudangukayum 50 vayass praayamulla sthreekalil pettennundaakukayum cheiyunnu. echpiji axis asanthulithamaakumbol, sellular valarchayum vikaasavum aniyanthrithamaakukayum sell maranavum pravarthanarahithathayum sambhavikkukayum cheiyunnu, iva randum sensensinu thudakkamidukayum, kaalakramena koshangal, tissukal, avayavangal ennivaykku sambhavikkukayum, vaardhakyakaalathu pravartthana nashtavumaayi bandhappettirikkukayum cheiyunnu.
eee sidhaanthathe pinthunaykkunna thelivukal roga padanangalil ninnu varunnath, pinneedu aarthavaviraamathil athunna sthreekalkku hrudrogavum strock kuravaanennum demensia kuravaanennum austioporosis kuravaanennum kaanikkunnu, ithu echpiji axis ethratholam santhulithamaayirikkunnavo athratholam praayam sambandhamaaya rogangal varaanulla saadhyatha kurravaanenna sidhaanthathe pinthunaykkunnu. neremarichu, aadyakaala sasthrakriya aarthavaviramam eee rogangalude vyaapanam vardhippikkumennu theliyikkappettittund. ennirunnaalum, ettavum sakthamaaya pinthuna nalkunna thelivukal hormon replacement theraappiyekkurichulla (echarty) padanangalil ninnaan. echarty ettedukkunna sthreekalumaayum purushanmarumaayum nadatthiya gaveshanangal kaanikkunnath manushya hormonukalumaayi jaivashaasthraparamaayi saamyamulla laingika hormonukal kazhikkunnath aarambhathe vaikippikkukayum, rogangalude ennam kuraykkukayum, hrudrogam, alsheimer rogam, austioporosis, chila tharatthilulla cancer thudangiya praayavumaayi bandhapetta rogangalude gathiye vipareethamaakkukayum cheiyumennu. ennirunnaalum, jaiva hormonukalkku maathrame eee phalangal undaakoo. manushyetara allengil synthetic hormonukalude upayogam eee rogangalil chilathinte apakadasaadhyatha vardhippikkumennu theliyikkappettittund. 18 padanangal echarty edukkunna sthreekalude deerghaayussu vardhikkunnathaayi theliyichittundu.
eee sidhaanthathe pinthunaykkunna kooduthal padanangal kaanikkunnath, jeevikalkk kalori niyanthranam, thanupp allengil vyayaama sammarddam enniva anubhavappedumbol, echpiji achuthandu adichamarthunnathu ayuss vardhippikkunnu ennaanu. echpiji axis signalling prathyulpaadanavum adichamarthaan jeevikale anuvadikkunna oru parinaama samrakshitha samvidaanamaayi ithu kanakkaakkappedunnu, athuvazhi santhathikale valarthaan paristhithi kooduthal anuyojyamaakumbol prathyulpaadana vibhavangal (anukkal) samrakshikkunnu. ore hormonukal prathyulpaadanatheyum vaardhakyatheyum niyanthrikkunnathiloode, oru mrugathinu paaristhithika saahacharyangale adisthaanamaakki athinte phalabhooyishtathayum vaardhakya nirakkum niyantrikkaan kazhiyum.
sameepakaalathe parabiosis padanangal vaardhakyathinte prathyulpaadana kosha-chakra sidhaanthathinte pala thathwangalum theliyikkunnu. eee pareekshanangalil, oru yuva eliye prayamaaya eliyumaayi shasthrakriyayiloode bandhippikkunna eee pareekshanangalil, yuva eliyil ninnulla rakthachamkramana gadakangal pazhaya elikalude koshangale punarujjeevippikkunnu. prathyekichum, eee padanangal neuronalinte (villeda thudangiyava) paripalanam niyanthrikkunnathil rakthachamkramana gadakangalude praadhaanyatthe soochippikkunnu., 2011), vascular (kathsimpardy thudangiyavar.2014), muscular aandu liver (konboy thudangiyavar., 2005; sinha mattullavarum.2014) ghadanayum pravartthanavum.

