model

chromosomukalude gadanaaparamaaya paripalanam protein 3 (smc 3) manushyaril smc 3 jeane encode cheiyunna oru proteinaan. sisttar chromatid koheshan, homologous recombination, dna looping ennivaykku madhyasthatha vahikkunna cohezin complexinte oru upavibhagamaanu smc 3. model, smc3, smc1, raadu21 allengil allengil enniva chernnaanu cohezin roopappedunnathu. manushyaril, ellah cohezin complexukalilum model kaanapedunnu, athesamayam mattu subunitukalkku onniladhikam paaraalogukal undu.
smc protein kudumbatthile amgamaanu model. dna attakuttappanikal, chromosome ghaneebhavippikkal, chromosome verthirikkal ennivayude pradhana niyanthrakaraan eee kudumbatthile amgangal.
ghadanayum edapedalukalum.
smc proteinukalude domaine oorganaiseshan parinamaparamaayi samrakshikkappedunnu, koodaathe oru enn-terminal wacker, oru motif, coiled-koyil, "hinch", coiled-koyil, oru sii-terminal wacker bii motif enniva ulkkollunnu. protein svayam madakki oru attathu heterodimerisation "keel" domain maruvashathu abc-type atpes "head" ulla oru vadi aakruthiyilulla thanmatra roopappedunnu. eee golaakrithiyilulla domainukale oru ~ 50 enm aanti-paralal koyil-koyil kondu verthirikkunnu. model, smc3 enniva avayude keel domainukaliloode bandhippichu vii-aakruthiyilulla heterodymerukal srishtikkunnu. raadu 21-nte enn-terminal domaine head domaine thottumukalil smc 3-nte churuttiya koyilumaayi bandhippikkunnu, athesamayam raadu 21-nte sii-terminal domaine smc 1-nte head domainumaayi bandhippikkunnu. smc 3-smc 1-raadu 21 trimerinte eee end tuu end binding dna entrap cheyyaan kazhiyunna oru clossed ring srishtikkunnu. ezz. eiii. 1 allengil 
dna aavarthikkukayum sisttar chromatid koheshan sthaapikkukayum cheyyumbol smc 3 esco 1, esco 2 enniva upayogichu valare samrakshikkappetta oru jodi laisinukalil asattailettu cheiyunnu. valarunna yeesttil eee parishkkaranam maittosis vare dnal kohesin sthirappeduthaan paryaapthamaan, ennaal mrugangalil sororin bandhippikkunnathum aavasyamaanu.
meosis samayat, model smc3babaiiieiiis, smc1bs, staag3 ennivayulla cohezin complexukal roopappeduthunnu, ithu homologous chromosomukalum sisttar kromaattidukalum thammil aikyam srishtikkunnu.
cornelia dii laang syndrome.
dysmorphic savisheshathakal, gurutharamaaya valarchaa vaikalyam, aagola vikasana kaalathamasam, boudhika vaikalyam ennivayulppede variable klinikkal asaadhaaranathakal avatharippikkunna oru apoorva janithaka vaikalyamaan cornelia dii laang syndrome (cdls). cdlcl ulppettirikkunna anchu jeenukalil onnaanu model. oru cases reportil, valarunnathil parajayappetta oru kuttiyil oru puthiya smc 3 jeane duplication kandethi, hypotonia, cdlukalude fasial dysmorphic savisheshathakal. neriya dysmorphic mukhangalulla ammayilum ithe pakarpp kaanapettu.
mouse model.
model pravarthanathekkurichu padanatthil maathrukaa jeevikal upayogichittundu. thaalpparyamulla shaasthranjarkku rogathinte mruga maathrkakal srishtikkunnathinum vitharanam cheiyunnathinumulla uyarnna-throoput mutagenesis projectaaya anthaaraashtra nokkautt mouse kansorshyam prograaminte bhaagamaayi bhaagamaayi (ucom) ibluts" ennu vilikkunna oru vyavasthaapitha nokkautt mouse line srishtichu.
illaathaakkalinte phalangal nirnnayikkaan aann, penn mrugangal oru staanderd phenotypic screenin vidheyamaayi. mutent elikalil irupathirandu parisodhanakal nadathukayum aarr pradhana asaadhaaranathakal nireekshikkukayum cheythu. garbhaavasthayil homocygus mutent bhroonangalonnum thiricharinjittilla, athinaal mulayoottunnathuvare avayonnum athijeevichilla. bakkiyulla parisodhanakal heterosaigas mutent muthirnna elikalil nadatthi. sthreekalkku avarude santhathikalil saadhaaranayekkaal kooduthal mulayoottunnathinu munbulla maranavum sareerabhaaram kurayukayum cheythu. aann heterosaigottukal cheruthum uyarnnathumaaya mookk pradharshippichu.
basement membranile punk.
sravikkunna proteinaayi chila kosha tharangalil smc 3 sambhavikkunnu, koodaathe kondroyittin sulfate shringalakalude poost-translation kootticherkkal sravikkunna proteoglycan bamaakan enna samriddhamaaya basement membran proteinu kaaranamaakunnu.

