
maikkal iii. oo 'donnel

maikkal iii. oru american biochemistum dii. enn. eiii replication mekhalayil prathyekathayulla rockfeller sarvakalaashaalayile professorumaanu ooo 'donnel.
vidyaabhyaasam.
donnel portland sarvakalashaalayil chernnu, bii.1975-ll. thudarnnulla biruda padanatthinide mishigan sarvakalashaalayil addeham oru ensimologistaayi pariseelanam nedi; addeham phd nedi.dii. 1982ll biochemistryil birudam nediya ooo 'donnel nobal sammana jethaav arther konberginteyum oo. aii. yudeyum melnottatthil stanford sarvakalashaalayil thante poost doctoral pariseelanam thudarnnu. nuclic assid ensaimolaji mekhalayile roobert lehmann.
gaveshanavum thozhilum.
1986ll audonal cornell yooniversitti medical collegil svanthamaayi laab aarambhichu. 1996ll addeham thante laab rockfeller sarvakalaashaalayilekk maatti. dna replicationil ulppedunna proteinukalude samvidaanam vyakthamakkunnathil addehathinte gaveshanathinte lakshyam shradha kendreekarikkunnu. eee proteinukalude biochemical pravartthanangalum avayude bhauthika gadanakalum padikkunnathu addehathinte sameepanathil ulppedunnu. ettavum shradheyamaayi, dna-sliding clamp ennu vilikkunna pravarthanatthinaayi dna valayam cheiyunna aadyathe ring aakruthiyilulla protein oo 'donnel kandethi. dna clamp dna polymerasine athinte dna templettilekku bandhippikkunnu, athuvazhi polymerasine neelamulla genomeukale kaaryakshamamaayi samanvayippikkaan anuvadikkunnu. joonn kuriyanumaayi sahakarichu, bacteria beetaa klaambinteyum manushya pii. sii. enn. eiii klaambinteyum gadanakal avaa nirnnayichu, avaa eathaandu superimpossible aaya valayangal roopappeduthunnuvennum athinaal avaa oru pothu poorvvikane pankidunnuvennum kaanikkunnu. dnaude thanippakarppil ulppedunna niravadhi ensaimukalekkurichulla addehathinte pravartthanam bacteria muthal eucariotic sisttangal vare vyaapichukidakkunnu.
avaardukalum bahumathikalum.
1990ll howard huggus medical instittyoottil oru anweshakanaayi. 2006ll yunaittad stetts naashanal akkadami oof sayansasilekku thiranjedukkappettu. rockfeller yooniversitti addehathe aanthaniyaayum 2008ll judith evnin professorayum niyamichu.

