
noxiustoxin

volteju-ashrita pottasyam chaanalukaleyum kaalsyam-activated pottasyam chaanalukaleyum thadayunna meksikkan thelinte "centruroids" noxius hofmante vishathil ninnulla oru vishamaan noxiustoxin (entx).
srothassukal.
meksikkan thel "centruroids noxius" hofmante ekeekritha asamskritha visham sathil ninnaan enn. tii. ex aadyamaayi shudheekarichathu, ithu meksikkan samsthaanamaaya nayaarittil kaanapedunnu. thelinte vishathinte oru sathamaanam maathramaan enn. tii. ex.
thelinte vishangalil ninnu ettavum nannayi padicha visha peptaidukalilonnaanu enn. tii. ex. neurotoxin II nuu sesham centruroids janussil ninnu labhikkuna randaamathe shudheekaricha vishavasthuvum saahithyathil report cheyyappetta thelinte vishathil ninnulla aadyathe hraswa peptaidumaanu ithu. 1982laanu noxiustoxin enna peru aadyamaayi nirddeshikkappettathu, athinumumbu ithu toxin II-11 ennariyappettirunnu.
rasathanthram.
39 amino assid avashishtangal adangiya oru peptaidaanu enn. tii. ex. ithinu 4195.06 enna mollar pindove inipparayunna praadhamika amino assid shreniyum undu tiinvkctspkkkcskpckellygssagakcmngkckccccyn-nh2. ntx-nte shreniyil histidin, arjinin, tryptophan allengil phenylalanine enniva adangiyittilla. enn. tii. exinu moonnu disulfide paalangalund (sisa 7-sisa 29, sisa 13-sisa 34, sisa 17-sisa 36) koodaathe oru madhyathilulla sii-terminus adangiyirikkunnu. enn. tii. ex. maargattoksin (79 sathamaanam aidantitti), caleotoxin (51 sathamaanam aidantitti), charibdotoxin (49 sathamaanam aidantitti), iberiotoxin (38 sathamaanam aidantitti) ennivayude shreniyil samaanamaan. nuclear magnetic resonance (enmr) upayogichaanu entxinte trimana parihara ghadana pariharichathu.
lakshyam.
chaanal risapttar saittilekk reversible aayi bandhippichu entx niravadhi tharam volteju gated keey + chaanalukalude sushirathe thadayunnu. koodaathe, ithu asthikooda peshikalude kaalsyam-activated pottasyam chaanalukale badhikkunnu. squid axonil, chaanal proteinil (keddy = 300enm) ntxinu avayude taargett saittumaayi thaarathamyena kuranja binding aduppamundennu kandethi.
pravartthana reethi.
enn. tii. ex. keey + chaanalukalumayi thirichupokunna reethiyil bandhappeduthukayum angane mastishka sinaptosomukalile keey + praveshanakshamatha kuraykkukayum cheiyunnu. enn. tii. ex.-nte sajeevamaaya sthalathinte sthaanam ithuvare poornnamaayum arivayittilla. ennirunnaalum, entxinte enn-terminal seekwansukalumaayi poruthappedunna synthetic-nonepeptide entx 1-9 nalkunnathinaal ithu vishavasthuvinte enn-terminal bhaagathinu sameepamaan sthithicheyyunnathennu vishwasikkappedunnu, ithu native entxumaayi valare saamyamulla lahariyude lakshanangalilekku nayikkunnu, athesamayam entxinte sii-terminalumaayi poruthappedunna randaamathe synthetic active sakalam lahariyude lakshanangalilekku nayichilla.
koodaathe, enn. tii. eksinte pravartthana reethi eakaagrathaye aashrayichirikkunnathaane karuthappedunnu. k + vaidyuthadhaarakal volteju-swatantra reethiyil 1.5 micrometeril thaazheyum volteju-ashrita reethiyil 1.5 micrometeril mukalilum ulla saandrathayil ntx thadayunnathaayi kandethiyittundu. enn. tii. ex vazhi keey + chaanalukal thadayunnathu orikkalum poortthiyaakilla, ithu soochippikkunnathu enn. tii. excinu oru chaanal poornnamaayum thadayaan kazhiyillennum allengil ellah chaanalukalkkum enn. tii. ex.-naayi oru risapttar saitt illennum soochippikkunnu.
vishaamsham.
intraperittoniyal kuthivayppinu sesham albino elikalil 0.26 microgram/gram aanu vishathinte eldie50. hyperrexitability, lacrimation, involution, umineer, dyspnia, oduvil shwasana pakshaaghaatham moolam maranam ennivayaanu elikalil undaakunna lahari lakshanagal.
chikitsa.
centruroids noxius" enna visham ellah meksikkan thelukalilum ettavum vishaamshamullathaanenkilum, "centruroids" noxius manushyarumaayi sahavasikkathathinaal ithinu vaidyashaasthraparamaayi praadhaanyamilla.
vaidyashaasthraparamaaya praadhaanyam.
vishavasthukkal thammilulla gadanaaparamaaya saamyam kaaranam, "centruroidukal noxiusine"thiraaya oru vaxine kooduthal pothujanaarogya prashnangalkk kaaranamakunna mattu apakadakaramaaya "centruroidukal" enangalkkethire kaaryakshamamaakumenn abhipraayappedunnu.