
vaan slike nischayadaartyam

praadhamika amine group adangiyirikkunna amino aasidukal nirnnayikkunnathinulla oru raasa parisodhanayaanu vaan slike nirnayam. biochemist donald dekstar vaan slikinte (1883-1971) peraanu ithinu nalkiyirikkunnath. 
vaan slikinte aadya professional nettangalilonnu vaan slike nirnaya prathikaranatthiloode amino aasidukalude alavu nirnnayikkuka ennathaayirunnu. aliphatic amino aasidukalude alavu nirnnayikkaan, sample glycerolil layippikkukayum thudarnnu soodiyam naitrait, vellam, asattik assid ennivayude layani upayogichu samskarikkukayum cheiyunnu. thathfalamaayundaakunna diasotisation prathikaranam naitrajan vaathakam uthpaadippikkunnu, athu gunaparamaayi nireekshikkaano alakkano kazhiyum.
vaan slike prathikaranam
<kemm> aarr-enh2 + hoonoo-> roh + enn2 + echu2oo </kemm>
koodaathe, vaan slike vaan slike upakaranam vikasippichu, ithu rakthathile shwasana vaathakangalude saandrata, prathyekichu soodiyam bicarbonatinte saandrata nirnnayikkaan upayogikkaam. kshara chikitsa aarambhikkunnathin, prameharogikalil oru prarambha acidosis ethrayum vegam thirichariyaan kazhiyunnath valare pradhanamaayirunnu. vaan slike upakaranam lokamembaadumulla klinikkal laborattarikalil oru saadhaarana upakaranamaayi maari, vaan slikinte gaveshanathinte phalangal assid-bays homeostaasisile asaadhaaranathakal nirnnayikkaan innum upayogikkunnu. pinneedu, vaan slike thante upakaranam kooduthal mechappeduthi, athinte krithyathayum samvedanakshamathayum vardhippichu. puthiya reethi upayogichu, rakthathile vaathakathinteyum electrolyte santhulithaavasthayudeyum pankinekkurichum shwasanathodulla prathikaranatthil avaa engane maarunnuvennum kooduthal anweshikkaan addehathinu kazhinju.

