
chrisaborol

muthirnnavarilum kuttikalilum neriyatho mithamaayatho aaya attopik dermatitis (exima) chikilsaykkaayi upayogikkunna oru nonstiroyidal topical marunnaan eukrisa enna brand naamatthil vilkkunna chrysaborol.
aaplikkeshan saittile prathikaranangalaan (kathunnatho kudukkunnatho ulppede) ettavum saadhaaranamaaya paarshwafalangal.
chrisaborol oru phosphodiistares 4 (pii. dii. iii-4) inhibittaraanu, ennirunnaalum attopik dermattaittisile pravartthanatthinte prathyeka samvidaanam ariyilla.
paarshwafalangal.
prayogikkunna sthalathu, chrisaborol kathunnathino kudakkunnathino kaaranamakum. apoorvvamaayi, oru allergy prathikaranam undakam.
medical upayogangal.
amerikkayil, moonnu maasavum athil kooduthalumulla aalukalil neriyatho mithamaayatho aaya attopik dermattaittisinte topical chikilsaykkaayi chrisaborol soochippikkunnu.
europian yooniyanil, shareera uparithala vistheernnam (bsa) 40 sathamaanathiladhikam baadhicha rund vious athil kooduthalumulla aalukalil neriyatho mithamaayatho aaya attopik dermatitis chikilsaykkaayi chrysaborolinu amgeekaaram nalkiyirunnu.
farmacology.
pharmacodynamics.
pradhaanamaayum phosphodiistares 4bii (pde4bii) yill pravartthikkunna oru phosphodiistares-4 inhibittaraanu chrisaborol, ithu veekkam undaakkunnu. raasaparamaayi, chrisaborol oru phenoxybensoxaborolanu. tumour necrosis factor alfa (tnfa), interlookkin-12 (ail-12), ail-23, rogaprathirodha prathikaranatthilum veekkathilum ulppedunnuvennu vishwasikkappedunna mattu cytokainukal ennivayude prakaashanatthe pde4bii thadayunnathu adichamarthunnu.
attopik dermatitis ullavar cytochines enna uyarnna alavilulla proteinukal uthpaadippikkunnu, ithu dermattaittisil kaanapedunna charmmatthinte veekkam undaakkum. tumour necrosis factor alfa, interlookins (il-2, il-4, il-5), interferon gaama thudangiya veekkam prakriyayil ulppedunna chila cytokainukalude prakashanam chrisaborol thadayunnu. avayude prakashanam thadayunnathiloode, chrisaborol veekkam laghookarikkumennum athinaal rogathinte lakshanangalil ninnu aashvaasam nalkumennum prathekshikkunnu.
rasathanthram.
chrisaborol (rasanamam 4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl) ooksi] benzonitrile) bensoxaborolukalude oru vibhaagathile amgamaanu, ithu oru phenolic eetharum nitrile ulla boronic assid hemisterinte saannidyamaanu. oxaborol valayathinte roopeekaranathil vyathyasamulla rund polymorphukalaayi chrisaborol christalise cheiyunnu. 4, 4 '-bipyridine ulla oru kokristal ex-reey christalography thayyarakkukayum padikkukayum cheythittundu.
charithram.
soriyaasisinte topical chikilsaykkaayi anaker farmaceuticals aanu chrisaborol vikasippichath. preclinical, klinikkal vikasana samayat, chrysaboroline aan 2728 ennum pf-06930164 ennum vilichirunnu. faisar anaker farmaceuticals etteduthappol eee marunnu prathivarsham 2 bilyan dollar blockbuster akumennu karuthappettu. ennirunnaalum, 2018-ll vilppanayilum 2019-ll vilppanayilum maathram ethiya eee marunnu vaanijyaparamaayi vijayichilla.
2016 desemberil amerikkayil upayogikkunnathinum 2018 juunil kaanadayil upayogikkunnathinum chrisaborol amgeekarichu.
rund placibo niyantritha pareekshanangalil chrysaborolinte surakshyum falapraptiyum sthaapichu, rund vayass muthal 79 vayass vare praayamulla 1,522 pankaalikal, neriyatho mithamaayatho aaya attopik dermatitis. rund pareekshanangalilum pankedutthavarkku 28 divasathekku divasathil randuthavana chrisaborol allengil placibo upayogichu chikitsa labhichu. pareekshanangal poortthiyaakunnathuvare eathu chikilsayaanu nalkunnathennu pankedukkunnavarkko aarogya parirakshaa daathaakkalko ariyillaayirunnu. mothatthil, chrisaborol sweekarikkunna pankaalikal 28 divasathe chikilsaykku sesham thelinjatho eathaandu thelinjatho aaya charmmatthil kooduthal prathikaranam nedi. amerikkayil vechaanu vichaarana nadannathu.
europian unionile mithamayathum mithavumaaya attopik dermatitis chikilsaykkaayi amgeekaricha chrisaborol europian vipaniyil ninnu athivegam pinvalichu (march 2020-februvari 2022).