intercellulaar clift

rund koshangalkkidayilulla oru chaanalaan intercellulaar clift, athiloode thanmathrakal sanjarikkukayum gapp jangshanukalum irukiya jangshanukalum undaakukayum cheyyaam. ettavum shradheyamaayi, rakthakkuzhalukaludeyum lymphatic naalangaludeyum endotheliyathinum epithelial koshangalkkumidayil intercellulaar villalukal palappozhum kaanapedunnu, ithu njarambukalkku chuttumulla raktha-naadee thadassam roopappeduthaanum sahayikkunnu. endotheliyathiloode draavakangalum cheria draavaka dravyangalum kondupokaan anuvadikkunnathinu intercellulaar villalukal pradhaanamaan.
intercellulaar klifttinte alavukal.
intercellulaar villalukalude alavukal shareerathiludaneelam vyathyaasappedunnu, ennirunnaalum kaappilarikalude oru parambaraykku villalinte neelam nirnnayikkappettundu. kaappilarikalude sharashari villal neelam ekadesham 20 meter/centimeter aanu. luminal muthal abluminal thurakkal vare alakkunna intercellulaar villalukalude aazham vividha tharam kaappilarikalkkidayil vyathyaasappedunnu, ennaal sharashari 0.7 micrometeraanu. intercellulaar villalukalude veethi junctional mekhalaykku purathu ekadesham 20 enm aanu (i.iii. villalukalude valia bhaagath). kaappilarikalude intercellulaar villalukalil, intercellulaar villal kaivashappedutthiya capillary mathilinte bhinnamaaya vistheernnam 20 meter/centimeter 2 x 20 enm (neelam x veethi) = 0.004 (0.40%) aanennu kanakkakkappettittund. cheria hydrophilic solyoottukaludeyum draavakangaludeyum swatantra vyaapanathinaayi thurannukaattappedunna capillary mathilinte bhinnabhaagamaanith.
villal vazhiyulla ashayavinimayam.
sell-sell aashayavinimayathin intercellulaar clift anivaaryamaan. villalil gapp jangshanukal, taitt jangshanukal, desmosomukal, folloran proteinukal enniva adangiyirikkunnu, ivayellaam signal transduction, uparithala resepterukal allengil oru keemogradiyant ennivayiloode kosha ashayavinimayam pracharippikkanum/allengil niyantrikkaanum sahayikkunnu. endocytosis, phagocytosis allengil risapttar-mediated endocytosis enniva vazhi oru thanmatra koshatthilekku kondupokunnathinu, palappozhum aaa thanmatra aadyam pilarppiloode praveshikkanam. intercellulaar villal thanne oru chaanalaan, ennaal ionukal, draavakam, cheria thanmathrakal enniva polulla chaanaliloode ozhukunnathum chaanalin krameekarikkaan proteinukal allengil jangshanukal nalkunnathum intercellulaar villalinte athirthiyilulla koshangalude aayussil nirnaayakamaan.
villal ashayavinimayam upayogichu gaveshanam nadatthuka.
koshathalatthile gaveshanathinu oru koshatthe kuthivaykkunnathinulla maargamaayi proteinukal, ionukal allengil nirddishta cheria thanmathrakal intercellulaar klifttilekku ethikkaan kazhiyum. pakarchavyaadhiyaaya cytosolic protein aggregettukalude sell-tuu-sell prachaaranatthinu eee reethi prathyekichum upayogapradamaanu. oru padanatthil, yeest priyanukalil ninnulla protein aggregettukal sasthanikalude intercellulaar villalilekku vidukayum nerittulla kosha kaimattatthinu vipareethamaayi aduthulla koshangal ettedukkukayum cheythu. retrovirusukalil kaanunnathupole, rogaprathirodha samvidaanathile koshangal thammilulla synaptic pilarppiloode pakarchavyaadhi kanangalude sravathinum vyapanathinum samanamaayirikkum eee prakriya. intercellulaar protein aggregate traansfarinte vazhikal, prathyekichu villalukal ulppedunna vazhikal manasilaakkunnath eee anubaadhayude purogamanaparamaaya vyaapanam manasilaakkunnathin anivaaryamaan.
intercellulaar clifttil gathagatham.
endothelial taitt jangshanukal saadhaaranayaayi intercellulaar clifttil kaanapedunnu, ithu membranukaliloode vyaapanathinte niyanthranam nalkunnu. intercellulaar klifttinte ettavum apical vashathaan eee linkukal saadhaaranayaayi kaanappedunnath. avaa macromoleculeukal intercellulaar clifttil sanjarikkunnathil ninnu thadayukayum appikkal, baasolaattaral sell uparithala domainukalkkidayil intrinsik membran proteinukaludeyum lipidukaludeyum laattaral defusion parimithappedutthukayum cheiyunnu. kaappilarikalude intercellulaar villalukalil, neutrophil interendothelial villalilekku thulachukayarumbol allengil rakthakkuzhalile lumene sabendothelial spaceumaayi bandhippikkunna vidavu 2. capillary endotheliyathil, plasma intercellulaar villaliloode intersteeshyal draavakavumaayi ashayavinimayam nadathunnu. plasma proteinukal, chuvanna rakthaanukkal, platelettukal ennivayillaatha raktha plasma intercellulaar pilarppiloode capillary 7 lake kadannupokunnu.
capillary intercellulaar villalukal.
ettavum shradheyamaayi, capillary rakthakkuzhalukalil intercellulaar villalukal vivarikkappedunnu. moonnu tharam capillary rakthakkuzhalukal thudarchayaayathum fenestrated, discontinuesed aanu, thudarchayaayi moonnil ettavum kuranja sushirangalullathum discondinues kaappilarikal valare uyarnna praveshanakshamathayullathumaan. thudarchayaaya raktha kaappilarikalkk ettavum cheria intercellulaar pilarppukalundu, thudarchayaaya raktha kaappilarikalkk ettavum valia intercellulaar pilarppukalundu, saadhaaranayaayi basementil membrane6.often vidavukalode, intercellulaar pilarppukaliloode kaappilarikalil ninnu draavakam puratthekku nirbandhikkappedunnu. kappilariyude dhamanikalude attathulla intercellulaar villaliloode draavakam puratthekku thallappedunnu, kaaranam avideyaanu ettavum uyarnna marddam. ennirunnaalum, eee draavakathinte bhooribhaagavum sirayude attathulla kaappilariyilekk madangukayum capillary draavaka chalanathmakatha srishtikkukayum cheiyunnu. rund ethir sakthikal eee santhulithaavastha kaivarikkunnu; hydrostatic mardhavum colloid ausmotic mardhavum, intercellulaar villalukal upayogichu draavaka praveshana kavaadangalum draavaka eksittukalum aanu. koodaathe, capillaryile intercellulaar villalukaludeyum sushirangaludeyum valuppam eee draavaka kaimaattatthe swaadheenikkum. intercellulaar villal valuthaakumbol, marddam kurayukayum kooduthal draavakam villaliloode ozhukukayum cheyyum. palappozhum histaamain, bradikinin thudangiya padaarthangal moolamulla capillary endothelial koshangalude sankochamaanu villalinte eee valarchaykku kaaranam. ennirunnaalum, cheria intercellulaar villalukal eee draavakam kaimaattam cheyyaan sahayikkunnilla. draavakathodoppam, electrolyteukalum capillary rakthakkuzhalukalil eee gathaagathatthiloode kondupookunnu. draavakam, electrolyte, cheria solute exchange ennivayude eee samvidaanam vrukka glomerular kaappilarikalil prathyekichum pradhaanamaan.
intercellulaar klifttum bii. echu. biyum.
raktha-hridaya thadassam (bii. echu. bii) roopappeduthunnathilum intercellulaar villalukal oru punk vahikkunnu. endocardial endotheliocyteukal thammilulla intercellulaar villal myocardial capillary endotheliocyteukal thammilulla villalukalekkaal 3 muthal 5 madangu vare aazhathilaan. koodaathe, eee pilarppukal palappozhum kooduthal valanjathum onno rando irukiya jangshanukalum soona anuyaayikalum oru sarkkmepharanshyal aaktin philament bandumaayum niravadhi connecting proteinukalumaayum samvadikkunnu. eee irukiya jangshanukal intercellulaar klifttukalude luminal vashath praadeshikavalkkarikkuppadu, avide sell-sell thirichariyunnathilum sell signalingilum pradhaanamaaya glycocalics kooduthal vikasippichirikkunnu. endocardial endotheliyathinteyum intercellulaar clifttinteyum oorganaiseshan vividha ayonukalude sajeeva transendothelial physicochemical gradient urappaakkikkond "raktha-hridaya thadassam" sthaapikkaan sahayikkunnu.

