
trimethylsilil isotheosainettu

naitrajan aattam trimethylsilil grouppumaayi sahavarthithvathode bandhippichirikkunna oru isotheosainettu adangiyirikkunna oru oorgaanoosilikkan samyukthamaanu trimethylsilil isotheosainettu (tii. emm. ezz. enn. sii). isosayanettu grouppinte analog aanu isotheosayanettu group, pakshe ooksijanu pakaram sulfur undu.
prathikaranangal.
jaiva rasathanthrathil upayogapradamaaya reactoraanu tii. emm. ezz. enn. sii. vividha alkail haalaidukal, asattalukal, aldehydeukal, apooritha samyukthangal, asiridinukal, ooksirenukal, polycyclic aarometik hydrocarbonukal, asattailetted hexosukal ennivayumaayi prathipravartthichu theosainett allengil isotheosainettu gadanakal roopappeduthaan kazhiyunna oru aambadant nucleophylaanu ithu. oru electrophyl enna nilayil, mattu nucleophylukalumaayi prathipravartthichu theomide tharatthilulla gadanakal roopappeduthaan ithinu kazhiyum, avayil chilath heterosaikkilukal roopappeduthunnathinu thudarnnulla prathikaranangalkk vidheyamaayekkaam.
hallid pakarakkar.
oru sulfur nucleophile enna nilayil, tii. emm. ezz. enn. sii. kall alkail substrateukalude shreniyil haalaidukalkk pakaramaayi alkail theosainettukal nalkunnu. eee pakara prathikaranangalil ghattam-kaimatta kaattalistaayi upayogikkunna tetrabutylamonium fluoride ulppedunnu, ithu prathyekichu mithamaaya saahacharyangalil sambhavikkunnu.
aldehydeukalumaayum asattalukalumaayum ulla prathikaranangal.
oru naitrajan nucleophile enna nilayil, tii. emm. ezz. enn. sii. kall aldehydeukalude carbonyl grouppiludaneelam cherkkukayum assid-catalised prakriyakaliloode asattalukalile eedhar grouppukalilonninu isotheosainettu pakaram vaykkukayum cheiyunnu.
mercapto-1,2,4-triasolukal.
uyarnna kaaryakshamathayum (88 sathamaanam vilavu), nirjjaleekaranam, nishkriya vathaka thaapanila allengil chromatographic shudheekaranam enniva aavashyamillaatha sammarddamillaatha avasthakalum kaaranam vyaavasaayika thalatthil mercapto-<aii. dii. 1>-tiasolukal thayyarakkunnathinulla oru ghatta reethi eshtappedunnu. eee reethi inipparayunna reethiyil sangrahikkaam benzohydrasidinteyum tii. emm. ezz. enn. sii. sinteyum ekwimolar mishrithathinu sesham 5 manikkoor ettoyude saannidhyathil, noah prathikarana mishrithathilekku cherkkukayum pariharam 4 manikkoor reflexes cheyyukayum cheiyunnu. asattik assid thanuppikkaanum nirveeryamaakkaanum upayogikkunnu, aathyanthikamayi shudhamaaya velutha kharamaaya 3-phenyl-5-mercapto-4h-1,2,4-triasol 88 sathamaanam vilavil nalkunnu.
2-amino-<aii. dii. 1>-ooksaadiyaasolukal.
2-amino-<aii. dii. 1>-ooksaadiyaasoolukalude samanvayathinu tii. emm. ezz. enn. sii. kall upayogikkunnu. tii. emm. ezz. enn. sii. riyejant theosemicbarbasidinte ulppaadanathinum thudarnnulla prathikaranatthinum sahayikkunnu (i2/q yude saannidhyathil adisthaana saahacharyangalil theosemicbarbasideukalu cyclodesulferisation) uyarnna vilavil 2-amino-1,3,4-oksaadiyaasolukalkku kaaranamaakunnu (79-94%).
eee prathikaranatthil ninnu undaakunna 2-amino-<aii. dii. 1>-ooksaadiyaasolukal ivayaanu 2-amino-5-phenyl-<aii. dii. 1>-ooksaadiyaasol, 2-amino-5-(pii-methylphenyl)-<aii. dii. 1>-ooksaadiyaasol, 2-amino-5-(pii-chlorophenyl)-<aii. dii. 1>-ooksaadiyaasol, 2-amino-5-(pii-methoxiphenyl)-<aii. dii. 1>-ooksaadiyaasol, 2-nitrophenyl-(pii-nitrophenyl)-<aii. dii. 1>-ooksaadiyaasol, 2-amino-5-(oo-methylphenyl)-<aii. dii. 1>-ooksaadiyaasol, 2-amino-5 (oo-chlorophenyl)-aii. dii. oxadiasol, 2-amino-5 (oo-chlorophenyl-oo

