
david hungerford

david eiii. oru american cancer gaveshakan philadelphia chromosominte saha-kandethalukaaranumaayirunnu hungerford (1927-1993). janithaka asaadhaaranathayum oru tharam cancer thammilulla aadya bandhamaayirunnu eee kandethal, ithu cancer gaveshanathinte disha maattukayum targettucheytha cancer chikilsakal vikasippikkunnathin vazhiyorukkukayum cheythu.
vidyaabhyaasavum aadyakaala currier.
david eiii. 1927ll masaachyusetsile broctonil janicha hurgenford filadelfiyayile temple yooniversittiyil ninnu birudam nedukayum pensylvania sarvakalashaalayil ninnu suvolajiyil phd nedukayum cheythu.
1959-ll, philadelphiyayile lanceno hospital instittyoott phoor cancer researchil juuniyar research fello aayi jolie cheiyunnathinidayil (pinneedu phoox chase cancer sentar srishtikkunnathinaayi american oongoolaji hospitalumaayi layippichu), yooniversitti oof pensylvania school oof medisinil paatholajistaaya peettar noval, philadelphia chromosome ennariyappedunnathu kandethi.
1961ll phd nediya sesham, aadyam instittyoott phoor cancer researchilum pinneedu 1974ll phoox chase srishtichathinusheshavum addeham rund pathittaandilere gaveshakanaayi chelavazhichu. multiple sclirosisinte phalangal kaaranam 1982ll addeham phoox chesil ninnu viramichu.
1993 november 3nuu shwaasakosha arbudam baadhichu pensylvaniayile jenkindaunilulla veettil vachu hurgenford marichu. addehathinte vidhavayaya alis hungerford deerghakaalamaayi phoox chase cancer sentarile jeevanakkaariyaayirunnu. aval avante paarambaryavum david eiii vazhi kurukkane pinthudarunnathumaayulla kudumbatthinte bandhavum nilanirthunnu. adisthaana chromosome gaveshanathil hungerford fund nalki. ellah septambarilum avar endovementinaayi panam swaroopikkunnathinaayi oru paripadi samghadippikkaarundaayirunu.
thante kandethal nadathumbol hungerford upayogichirunna microscope kurukkan vettayil sthiramaaya pothu pradarshanathilaanu.
philadelphia chromosominte kandethal.
kandethal samayat hungerford thante phd pinthudarukayum manushya kromasomukalekkurichulla oru prabandhathinaayi raktarbuda koshangale padikkukayum cheiyukayaayirunnu. vittumaaraatha myelogenous leukemia (sii. emm. ell) ulla rund rogikalil ninnu edutha kalchar cheytha rakthaanukkalil ninnu chromosomukalil oru cheria asaadhaaranatha addeham kandethi. eee asaadhaaranatha manushyaril kaansarumaayi bandhapetta aadyathe sthiramaaya janithaka kramarahithathayayi maarum. chromosome 22-nte bhaagavum angane athu vahicha janithaka kodukalil chilathum kaananilla. athrayadikam janithaka vasthukkal nashtappedumbol oru koshathinu pravarthanakshamamallennu hungerford novalum abhiprayappettu. ithu oru translocation aayirikkaamenn avar vishwasichu, athaayath kaanathaaya kashanam chromosomil mattoru sthalathu gadippichirikkaam, pakshe akkaalat labhyamaya saankethikavidyakal upayogichu athu theliyikkaan avarkk kazhinjilla. 1970kalude thudakkathil jaanett rauli ithu oru traanslokkeshanaannenn sthireekarichu.
gaveshakarude athath sthaapanangal sthithi cheythirunna nagaratthinte peril eee kandethaline philadelphia chromosome ennu vilichirunnu. avar 1960-ll naashanal cancer instittyoottinte jenalil avarude kandethalukal avatharippichu. akkaalat, microscopic padanathinaayi chromosomukal thayyarakkunnathinulla saankethikavidyakal ippozhum asamskrithamaayirunnu, koodaathe cml rogikalil ninnulla koshangalil asaadhaaranamaaya chromosomukalonnum gaveshakar kandethiyirunnilla. kooduthal padanangal kandethalukal sthireekarichu.
mattu shaasthreeya sambhavanakal.
soomatik metaphesu chromosomukalil banding teknikkukal avatharippikkunnathin munbu, beejathinte vikasanathil paachitteen ghattathil david chromasomukalekkurichu anweshikkaan thudangi. oro chromosomine oru prathyekavum swathasidhavumaaya banding paatten undu (pinneedu soomatik metaphesu chromosomukalude banding paattenumaayi bandhappettathayi kaanikkunnu), 1970 ll daun syndrome bandhapetta trisomy mutation miyosisil engane vikasichuvennu addeham vivarichu. 1982ll asukham moolam viramikkumbol, saadhaarana manushyanilninnu labhikkuna chromosomukalude pakuthiyolam paachitteenil vachu david mapp cheythirunnu.