norpinefrine-dopamine reaptekku inhibittar

klinikkal depression, attanshan dephisit hyper aaktivitti desorder (adhd), narcolepsy, paarkkinsans rogam ennivayude chikilsaykkaayi upayogikkunna marunnaan norpinefrine-dopamine reaptake inhibittar (indr). norpinefrine transporterinteyum (nettu) dopamine transporterinteyum (daatt) pravartthanatthe thadayunnathiloode neuro traansmittarukalaaya norpinefrine, dopamine ennivaykku reaptekku inhibittaraayi eee marunnu pravartthikkunnu. ithu norpinefrine, dopamine ennivayude extra sellular saandrata vardhippikkunnathilke nayikkunnu, athinaal adrenergic, dopaminergic neuro transmission vardhikkunnu.
norpinefrine-dopamine release ejantu (νDR) aanu adutha bandhamullah oru tharam marunnu.
enn. dii. aarr. aii. yude pattika.
thaazhepparayunnava ulppede niravadhi enn. dii. aarr. aii. kall nilavilunda
amphettaamainum athinte pala derivative (i.iii.dopamine transporter (daatt), norpinefrine transporter (nettu), serotonin transporter (sert) proteinukalude malsaraathmakamallaathathum mathsaraadhishtithavumaaya inhibittarukal koodiyaanu pakaram vaykkunna amphetamines). aamphettaamain thanne daatt, nettu ennivayumaayi thaarathamyappeduthumbol sertinode thaarathamyena kuranja aduppamaanu. thathfalamaayi, aamphettaamain saadhaaranayaayi oru sndriykk pakaram oru endriyaayi tharamthirikkunnu. ennirunnaalum, pakaramaayi upayogikkunna amphetamainsinu valare vaividhyamaarnna ephakt profileund, avayil palathinum sertle kaaryamaaya thadassappeduthunna falangalundu.
amphettaamainum mattu pala pakaramulla aamphettaamainukalum vimat 2-nte inhibittarukalum trace amine-anubandha risapttar 1 (taar 1)-nte sakthamaaya agonistukalumaanu; taar 1-nte agonism phosphorylation sambhavangale prerippikkunnu, ithu malsaraathmakamallaatha reaptekku inhibition monoamine transporter proteinukalude vipareeta gathagatha dishayinum kaaranamaakunnu. thalphalamaayi, monoamines koshatthil ninnu synaptic pilarppilekku ozhukunnu. athinaal, amphettaamainum athinte derivateevukalkkum classical endrisil ninnu valare vyathyasthamaaya oru pharmacological profile undu, pakshe amainukale kandethunnathinu samaanamaan.

