protheoconasole

praadhamikamaayi athinte fungisidal gunangalkkayi uthppaadippikkunna oru synthetic raasavasthuvaan protheoconasole. ithu samyukthangalude triasolukalude vibhaagathil amgamaanu, koodaathe eee klaas fungisideukalil savisheshamaaya toxophor undu. athinte phalapradamaaya fungisidal gunangalkk saip 51eiii1 thadayaanulla kazhivaanu kaaranam. fangasinte kosha stharathile pradhana gadakamaaya ergosteroline jaivasamshleshanam cheiyunnathinu eee ensime aavasyamaanu.
2004ll bair crop sayans aanu protheoconasole aadyamaayi vipaniyil avatharippichathu, pradhana dhaanya vilakalude niravadhi fungus rogangalkkethiraaya vishalamaaya pravartthanam kaaranam athivegam janapreeti nedi. prolin enna vyaapaaranaamathil ithu oru sooloo uthppannamaayum vaanijyaparamaayi uthppaadippikkunna mattu pala fungisideukalilum vividha mishrithangalilum upayogikkunnu.
synthesis.
2-chlorobenzil chloridinte grignard derivative 1-chlorocyclopropyl-2-chloro-eedhan-1-vaninte eratta bandhatthiludaneelam cherkkunnu. chloromethyl grouppinullile chloridine pakaram pinneedu 1,2,4-triasol upayogikkunnu. avasaanamaayi, 1,2,4-triasolil 5-aamm sthaanathu theokketton groupine avatharippikkunnathin, samyuktham aadyam enn-beautil lythium upayogichu lithiyett cheiyunnu, thudarnnu sulfur (ezz 8) cherkkunnu. eee synthesis enantio-selective allah, ithu oru racemic mishrithathinu kaaranamaakunnu.
raasa gunangal.
protheoconasole vellathil nannayi layikkunnillenkilum asettoon, esttarukal, polyethileen glycol ennivayil laikkam.
foto degeneration poorthiyaakunnathilekku neengunnu, foto degenerationte pakuthi ayuss 47.7h aanu.
ithu eluppathil jalavishleshanathinu vidheyamaakunnilla, athaayath 4 piechum 50 digri selshyas thaapanila 120 divasathinu sesham pakuthiyolam thanmaathrakalum jalavishleshanam cheyyappedunnu. praadhamika apachaya uthppannam protheoconasole-desthio aanu. eee uthppannathin mannil sharashari chalanasheshiyund, jalavishleshanathilekkulla sthiratha thalphalamaayi aerobic saahacharyangalil mannil athinte sthirathayilekku nayikkunnu, mannil motham kshayam ekadesham 14.7 divasamedukkum. jaleeya photolysisinum aerobic, vaayurahita jalajeevikalude apachayathinum ithu valareyadhikam prathirodhasheshiyullathaan.
toxicology.
vargeekaranam.
mruga padanangalude extrapolation protheoconasolilekkum athinte mettabolittukale eusepa "manushyarkk arbudamundaakkaan saadhyathayillaathava" ennu tharamthirikkunnathilekkum nayichu. ghs protheoconasole vilayiruthukayum athu jalajeevikalkk valare vishaamshamullathum deerghakaala phalangalullathumaanennu kanakkaakkukayum cheythu cheythu.
protheoconasolinte sveekaaryamaaya dainamdina upabhogam (adii) prathidinam 0.01 milligram/kilogram sareerabhaaramaanu, athesamayam acute reference doses (rfd) prathidinam 0.01 milligram/kilogram bidablue aanennu nirnnayichu.
vishaamsham.
vaayiloode kazhikkunnathaanu praadhamika maarggam enna nilayil mrugangalil pareekshanangal nadatthi. samyukthathe oru radio active labelilekku bandhippikkunnath samyukthathinte entohepatic rakthachamkramanam velippeduthi. loval, protheoconasole, athinte metabolittukal enniva karal, vrukkakal, moothrasanchikal ennivaye lakshyamidunnu. elikalil marakamaaya alavu (eldie 50) 6200 milligram/kilogram bidablue aanu. dermal eldie 50 nte alavu 2000 milligram/kilogram bidablyuvil kooduthalaanu, athesamayam 4 manikkoor shwasikkunna elsie 50 4.9 milligram/lill kooduthalaanennu nirnnayichu. hraswakaala padanangal prathikoola hepatic efakttukal, karal bharam vardhikkal, karal ensaimukalude vardhicha pravartthanam, microscopic shathangal enniva vilayiruthi. protheoconasole muyalinte annukalkku aswasthathayundaakkunnavum charmmathinu allennu report cheyyappettu. 24 manikorinullil 70 sathamaanathiladhikam visarjjikkunna malathiloodeyulla nirmmarjjanamaanu visarjjanathinte pradhana maarggamenn padanangal theliyichittundu. eliminationte ardhaayuss 44.3 manikkooraanennu kanakkakkappettu.
mrugangalile metabolism.
phineel grouppinte desulferation allengil auxidative hydroxylation, thudarnnu glucuronic aasidumaayulla samyojanam ennivayiloodeyaanu protheoconasolinte bio transformation purogamikkunnathu. pradhana metabolittukal anweshikkappetta ellah speesheesukalilum triasolinthiyon bhagam nilanirthunnu. randaam ghatta prathikaranangalude falamaayundaakunna protheoconasole-ezz-glucuronide aayirunnu pradhana mettabolite. karalileyum vrukkayileyum protheoconasole-desthio avashishtangalkk vyathyastha feeding thalangalil oru leanier doses-response bandham nireekshikkappettu.
sasyangalile metabolism.
anweshikkunna ellah sasyajaalangalilum kaanapedunna pradhana metabolaittaanu protheoconasole-desthio. protheoconasole-desthio protheoconasolum samanamaaya visha gunangal pankidunnu. swathanthramaaya 1,2,4-triasolinte saannidhyam kandethaanaavaathathinaal chedi mannil ninnu 1,2,4-triasol edukkukayum athine nerittu metabolisis cheyyukayum cheiyunnuvennu padanangal soochippikkunnu.
biochemical gunangal.
ashayavinimayam.
fungazidal pravartthanatthinte praadhamika samvidaanathil 14-aamm sthaanathu lanosterolinteyo 24-methyl dihydroyano-sterolinteyo demethylation prakriyayile nirnaayaka gadakamaaya saip 51 thadayunnathu ulppedunnu. eee prakriyayude thadassappedutthal ergosterolinte vaikalyamulla jaivasamshleshana samvidaanathinu kaaranamaakunnu. pala fungus speesheesukalilum kosha stharathinte gadanaykku athyanthaapekshithamaaya vitaamin dii 2-nte munnodiyaanu ergosterol.
protheoconasolinu thyroid peroxidaseumaayi edapazhakaanum thaalkkaalikamaayi adichamarthaanum kazhiyumennum padanangal soochippikkunnu. 2i− ll ninnu i2 roopeekaranathinu eee ensime utharavaadiyaanu. eee prakriya thadayunnathu manushyaril thyroxine allengil trioyodothyronine polulla thyroid hormonukalude uthpaadanam kuraykkaan kaaranamaakunnu.

