
poolisistin kaatteshan chaanal kudumbam

poolisistin kaatteshan chaanal (pii. sii. sii) kudumbatthil (tii. sii. #1. eiii. 5) 500 muthal 4000 amino asail avashishtangal (eiii. eiii. ezz) vare neelamullathum 5 muthal 18 vare transmembran segmentukal (tii. emm. ezz) pradarshippikkunnathumaaya niravadhi transporterukal adangiyirikkunnu. volteju gated ayoon chaanal (vii. sii.) suuppar faamiliyude oru gadakamaanu eee kudumbam. eee transporterukal saadhaaranayaayi kaatteshanukalude kayattumathiye uthejippikkunnu. pii. sii. sii kudumbatthilppetta proteinukalude oru praathinidhya pattika transporter classification daattaabesil kaanam.
kristtal gadanakal.
pii. sii. sii kudumbatthile amgangalkkaayi niravadhi kristtal gadanakal labhyamaan. avayil chilath ulppedunnu
pii. keey. dii1: 
poolisistik vrukkarogam 2-like 1 protein, 
pkd2:,,,,,, 
samavaakyangal.
human poolisistin.
4303 amino asail avashishtangal (aas) adangiya oru valia proteinaan human poolisistin 1. aavarthichulla lucine adangiya (elrr) bhagam pala proteinukalilum kaanapedunnu. swis prott vivaranamanusarichu, poolisistin 1-ll 16 poolisistik vrukkarogam (pii. keey. dii) domainukal, oru ell. dii. ell-risapttar klaas oru domaine, oru sii-type lekttin famili domaine, <aii. dii. 1> putatteevu tii. emm. ezz enniva avashishtangal 2200 num 4100 num edayilulla sthaanangalil adangiyirikkunnu. ennirunnaalum, aattomik fozhsu microscopy imaging poolisistin-1-nte domaine ghadana velippeduthi. ithu kuranja sequence samanathakal kaanikkunnu, ennaal samana domaine oorganaiseshanum membrane topology traansiyant risapttar pottensial (trp), volteju-gated ayoon chaanal (visi) famili proteinukal (yathaakramam tissy #1. eiii. 4, tissy #1. eiii. 1) enniva polulla sthaapitha kaatteshan chaanalukalund. ennirunnaalum, aavarthanangalillathe saii-spodanam eee samanathakal edukkunnilla. pkd2l1-pkd1l3 complexes pulicha ruchi manassilakkunnu. mechanocensationu kaaranamakunna pii. keey. dii. 2-pii. keey. dii. 1 complexinte thadassangal, eiii. dii. pii. keey. dii (autosomal-dominant poolisistik kidney disease) vikasikkunnathilekku nayikkunnu. chaanal pravartthanavum anubandha signalling evantukalum modulate cheiyunnathinupurame, pkd2, pkd2l1 ennivayude sii. aarr. dii. kall (sii-terminal regulatory domainukal) chaanal oligomerisationil oru pradhana punk vahikkunnu. eee proteinukal trimerukal roopappeduthunnathaayi kaanapedunnu.
poolisistin-ell.
poolisistin-ell ennathu caa2 + upayogichu sajeevamaakunna oru kaatteshan (naa +, keey +, caa2 +) chaanalaanennu theliyikkappettittund, athesamayam poolisistin-2 oru caa2 +-permible kaatteshan-selective chaanalaanennu visheshippikkappedunnu. pisi kudumbatthile rund amgangal (poolisistin 1,2; pii. keey. dii. 1 umm 2 umm) manushya autosomal dominant poolisistik vrukkarogathil parivartthanam cheyyappedunnu, koodaathe poolisistin-ell, pii. keey. dii 2-nuu valare saamyamullathum orupakshe orthologas aayirikkam, vrukka, rettina vaikalyangalulla elikalil illaathaakkappedunnu. pii. keey. dii. 1 umm 2 umm parasparam edapedukayum "inn vitro" enna noonn-selective kaatteshan chaanal roopeekarikkukayum cheiyunnu, ennaal mattu anubandha proteinukalude abhaavathil pii. keey. dii. 2 nuu chaanalukal roopeekarikkaan kazhiyum. poolisistin-2 vividatharam jaiva kattiyanukal (dimethylamine, tetrithylamonium, tetrabutylamonium, tetrapropylamonium, tetrapentanail amonium) kondupookunnu. chaanalinte vyaasam kuranjathu 1.1 Â aanennu kanakkaakkappettirunnu. iva randum yathaakramam 7-11 tMSs (pkd1), 6 tMSs (pkd2) ennivayulla avibhaajya membran proteinukalaanennu report cheyyappettittund. avaa ekadesham 400 avashishtangalude (pii. keey. dii. 2-ll avashishtangal <aii. dii. 1>; pii. keey. dii. 1-ll avashishtangal <aii. dii. 2>) oru ekeekritha pradesham pankidunnu, athil rund proteinukaludeyum anchu tii. emm. ezz ulppedunnu. ithu chaanal domaine aayirikkam. pkd2, poolisistin-l enniva volteju-, Ph-, daivaalant kaatteshan-dependent chaanal pravartthanam prakadippikkunnathaayi kaanichittundu. poolisistin-2 chaanal sajeevamaakkukayum sthirappeduthukayum cheiyunna pii. keey. dii. 1 praadhamikamaayi niyanthranatthil pravarthichekkaam.
shanikamaaya risapttar pottensial proteinukal.
traansiyant risapttar pottensial (tii. aarr. pii) poolisistin 2,3 (tii. aarr. pii. pii. 2 umm 3 umm) kaatteshan chaanalukalude tii. aarr. pii suuppar faamiliyile homologous amgangalaanenkilum avaykku vyathyastha physiological pravarthanangalundu. oru phloo sensarinte bhagamaaya tii. aarr. pii. pii2 autosomal dominant poolisistik vrukkarogathil thakararullathum idathu-valath asamathva vikasanathil ulppedunnathumaanu. naavinte ruchi mukulangalude bipolar koshangalil pulicha ruchiyum sushumna nadic chuttumulla neuronukalil piechu-sensitiivu aakshan pottensial niyanthrikkunnathum tii. aarr. pii. 3-ll ulppedunnu. rettina, masthishkam, hridayam, vrukka, vrukka thudangiya vividha koshangalile uthejakavum uthejakamallathathumaaya koshangalil tii. aarr. pii. pii. 3 kaanapedunnu.
mucolipin-1.
trippy-emm. ell. 1 protein (mucolipin-1) proteolytic pilarpp nirjjeevamaakkunna oru lysosomal monovalent kaatteshan chaanalaanennu theliyikkappettittund. ithu tii. aarr. pii-sisi kudumbatthile (tii. sii. #1. eiii. 4) amgangale apekshichu poolisistin 2-nte transmembrane mekhalayumaayi kooduthal sequence saamyam kaanikkunnu. athinaal, ithu muun kudumbatthil ulppeduthiyittundu. pii. sii. sii, tii. aarr. pii-sii. sii kudumbangal wick suuppar faamiliyile amgangalaanu.
alfa-actinine.
palatharam ayoon chaanalukale niyanthrikkunna ariyappedunna aaktin-bunding proteinaan alfa-actinine. planner lipid bilayer electrophysiology kaanikkunnath alfa-actinine ganyamaayi vardhippikkunna kaatteshan chaanal pravartthanangal tii. aarr. pii. pii 3 pradarshippikkunnu ennaanu. thaddesheeya koshangalum tissuekalum, yeest tuu-hibrid, inn vitro binding aseyukal enniva upayogichu qoo-immunopressipitation vazhiyaan tii. aarr. pii. pii 3-alfa-actinine association rekhappeduthiyittullathu. alfa-actinine-2-maayi bandhappedunna eliyude thalachoril tii. aarr. pii. pii. 3 daaraalamundu. alfa-actinine tii. aarr. pii. pii. 3-neey cytoskelittanumaayi bandhippikkukayum athinte chaanal pravartthanatthe niyanthrikkukayum cheiyunnu.
shaareerika praadhaanyam.
membranumaayi bandhapetta risapttar polulla protein fibrosisteen/polycudine (efpisi) (kyu8tcs9,4074aaa) encode cheiyunna phd1 leeii mutationukal moolamaanu autosomal resussive poolisistik vrukkarogam undaakunnath. efpisi epithelial koshangalude praadhamika siliayumaayi sahakarikkukayum pii. keey. dii 2 jeane ulppannamaaya poolisistin-2 (pii. sii 2)-maayi saha-locase cheyyukayum cheiyunnu. kiim thudangiyavar. vivoyil efpisiyum pisi 2 umm thammil pravartthanaparavum thanmathraaparavumaaya edapedal nilavilundennu (2008) nigamanam cheythittundu.