benzocane

oraajal enna brand naamatthil vilkkunna benzocane, amino esttar marunnu vibhaagathil pedunna oru praadeshika anasthettikkaanu, ithu saadhaaranayaayi topical vedanasamhaariyaayo chuma thullikalaayo upayogikkunnu. vaayile alsarinulla uthppannangal polulla niravadhi oonn-dhii-kaundar anaesthetic thailamarddangalil ithu sajeeva gadakamaanu. ithu aantipairainumayi samyojippichu eiii/bii iyar dropukal undaakkunnu. amerikkayil, rund vayassinu thaazheyulla kuttikalil benzocane adangiya uthppannangalkk virudhamaayi perumaarunnu. europian yooniyanil, 12 vayassinu thaazheyulla kuttikalkk eee ethirppu baadhakamaan.
1890ll germmaniyil aadyamaayi samanvayippicha ithu 1902ll vaidyashaasthraparamaaya upayogathinu amgeekarikkappettu.
medical upayogangal.
vedanayumaayi bandhapetta vividha avasthakal chikilsikkaan benzocane soochippikkunnu. ithu inipparayunnavaykkaayi upayogikkaam
benzocaininte kompineshan marunnukalude udaaharanangalil iva ulppedunnu
mattu upayogangal.
niravadhi farmaceuticalsil benzocane oru pradhana gadakamaayi upayogikkunnu
labhyamaya foomukal.
benzocane inipparayunnava ulppede vividha thayyaareduppukalil varaam
vaakkalulla thayyaareduppukal
samanthara thayyaareduppukal
oottik thayyaareduppukal
paarshwafalangal.
shupaarsha cheythathupole toppiyayi prayogikkumbol benzocane pothuve nannayi sahikkaavunnathum visharahithavumaan.
ennirunnaalum, gurutharamayathum jeevanu bheeshaniyulavaakkunnathumaaya prathikoola phalangal report cheyyappettittund (udha.jii., apasmarangal, cooma, kramarahithamaya hridayamidippu, shwasana vishaadam) topical uthppannangalude amithamaya prayogathodeyo allengil charmmatthil benzocaininte uyarnna saandrata adangiya topical uthppannangal prayogikkumbozho.
benzocane polulla ooral anaesthetics amithamaayi prayogikkunnathu gagg-reflex vishramikkunnathiloodeyum vayarile ulladakkamo vaayile sravangalo shwasanapathathilekku praveshikkaan anuvadikkunnathiloodeyum pulmonary aaspireshan saadhyatha vardhippikkum. urangaan pookunnathinumumbu ooral anaesthetic prayogikkunnathum paneeyangal kazhikkunnathum prathyekichum apakadakaramaanu.
vaayilo mucus membranukalilo prayogikkunna uyarnna saandrata (10-20%) benzocane uthppannangalude samayochitha upayogam methemoglobinemiac kaaranamakunnathaayi kandethiyittundu, ithil raktham vahikkunna ooksijante alavu valareyadhikam kurayunnu. rund vayassinu thaazheyulla kuttikalil eee paarshwafalangal ettavum saadhaaranamaanu. thalphalamaayi, oru aarogyaparipalana vidagthan nirddeshikkukayum melnottam vahikkukayum cheythillengil, rund vayassinu thaazheyulla kuttikalil benzocane uthppannangal upayogikkaruthennu fda prasthaavichu. europian rajyangalil, 12 vayassinu thaazheyulla kuttikalkk eee virudharekha baadhakamaan. methemoglobinemy lakshanagal saadhaaranayaayi benzokine puratti minittukal muthal manikkoorukalkullil sambhavikkunnu, ithu aadyamaayi upayogikkumbozho adhika upayogathinu sheshamo sambhavikkam.
benzocane allergic kaaranamakum. ivayil ulppedunnu
farmacology.
pharmacodynamics.
free naadi endingukalude uthejanam moolamaanu vedana undaakunnath. naadi attangal uthejippikkappedum, soodiyam neuronilekku praveshikkukayum ithu nadiyude depolarisation thudarnnu oru aakshan pottensial aarambikkunnathinum kaaranamaakunnu. aakshan pottensial naadiyiloode kendra naadeevyavasthayilekku pracharippikkappedunnu, ithu vedanayaayi vyaakhyaanikkunnu. neuron membranile volteju gated soodiyam chaanalukale (vii. dii. ezz. sii) thadayaan benzocane pravartthikkunnu, ithu aakshan pottanshyalinte vyaapanam thadayunnu.
rasathanthram.
pii"-aminobenzoic aasidinte (paaba) ethyl estaraanu benzocane. fisher esterification vazhiyo ethyl "pii"-nitrobensoate kuraykkunnathiloodeyo ithu paaba, ethanol ennivayil ninnu thayyarakkam. benzocane vellathil valarekkurachu layikkunnu; ithu nerppicha aasidukalil kooduthal layikkukayum ethanol, chlorophom, ethyl eedhar ennivayil valare layikkukayum cheiyunnu. bensocaininte dravanaangam <aii. dii. 1> ccm aanu, thilanila 310 ccm aanu. bensocaininte saandrata 1.17 gram/sem. mee. 3 aanu.
benzokine saadhaaranayaayi kaanapedunnu, prathyekichu brittanil, street kokkeynil oru aditeevaayum "niyamaparamaaya uyarangalil" oru bulking ejantaayum. benzocane kokkeyninu samanamaaya oru maravippikkunna prabhavam nalkunnu, oru bulking, binding ejantu enna nilayil ithu orikkal kalarthiya sesham kandethaan kazhiyilla. lokamembaadumulla ettavum janapriyamaaya cutting ejantaanithu. 
hydrassin upayogichu benzocane chikilsikkunnathu isoniasidumaayi bandhapetta samyukthamaaya aminostimililekku nayikkunnu.
synthesis.
4-aminobenzoic assid ethanolum upayogichu esterification vazhi benzocane thayyarakkam. ethyl 4-nitrobensoate amainaayi kurachukondu ithu thayyarakkanum kazhiyum. vyaavasaayika praayogikathayil, saadhaaranayaayi cheria aasidinte saannidhyathil irumbum vellavumaan kuraykkunna ejantu.
charithram.
1890-ll jarmman rasathanthranjanaaya edward ritsert (1859-1946) aanu benzocane aadyamaayi samshleshanam cheythath, 1902-ll "anaesthesin" enna peril vipaniyil avatharippichu.
vettinari medisin.
benzocaininteyum athinte derivetteevukaludeyum baath laayanikal saadhaaranayaayi shasthrakriyaykaayi ubhayajeevikale anastheshyayaakkaan upayogikkunnu. benzocane adisthaanamaakkiyulla anastheshyakal ubhayajeevikalile anastheshyaykkum dayaavadhathinum shakthavum valare phalapradavumaanu.

