anjana raavu

anjana raavu, pii. echu.dii.amerikkayil jolie cheiyunna indian vamshathile sellular, molecular biologistaanu. intra sellular signalling jeane expression manasilakkaan avar rogaprathirodha koshangalum mattu tharatthilulla koshangalum upayogikkunnu. signalling pathakal jeane expressione engane niyanthrikkunnu ennathil avarude gaveshanam shradha kendreekarikkunnu.
vidyaabhyaasavum thozhilum.
indiayile oosmaaniya sarvakalashaalayil ninnu bhauthikashaasthrathil birudaananthara birudam nediya raavu phd nedi.dii. harward sarvakalashaalayil ninnu biophysicsil birudam nedukayum daana-farber cancer instittyoottil poost doctoral fellowship poortthiyaakkukayum cheythu. 2010 vare harward medical schoolil pathology professoraayirunna avar laa jola instittyoott phoor immunology professorayum california saan diego sarvakalaashaalayile farmacology anubandha professorayum maari. avarude sahapravarthakayaya patrick hoganotoppam (laa jola instittyoott phoor immunology professor) avar calcimedica kambaniyude sahasthaapakayaanu. cancer gaveshanathe pinthunaykkunna oru foundeshanaaya jaine coffin childs board oof scientific advaisezhsil avar ettu varsham chelavazhichu, cancer koshangalude valarchayum vikaasavum niyanthrikkunnathil shradha kendreekarikkunna gaveshanangal. nilavil labhyamaya ettavum mikacha cancer chikilsakalilonnaaya cancer immunotheraappiyekkurathu shaasthreeya gaveshanathe pinthunaykkunna laabhechayillaathe pravartthikkunna samghadanayaaya cancer research instittyoottinte shaasthreeya upadeshaka samiti amgavumaanu avar.
avaardukal.
us naashanal akkadami oof sciences, american akkadami oof arts aandu sciences, american association phoor dhii advaansment oof sayans ennivayilekku raavu thiranjedukkappettittundu. american association oof immunologistukalim american sosaitti phoor biochemistry aandu molecular biologyilum avar amgamaanu.
gaveshanam.
harwardile raavuvinte aadyakaala gaveshanam enfaatt (activated tii-cellukalude nuclear factor) transcription gadakangalil shradha kendreekarichu, avaa poost doctoral fellomaaraaya jugnu jaine, paatt mcaffrey, sahakariyaaya patrick hogan ennivaril ninnu avar kandethi. enfaatt proteinukal mikka rogaprathirodha koshangalum prakadippikkunnuvennum rogaprathirodha prathikaranatthinu pradhanappetta jeenukalude transcription anivaaryamaanennum avar theliyichu. enfaatt niyanthrikkunnath kaalsyavum kaalsyam aashrithamaaya phoosphett calcinurine aanennum ithu enfaattil ninnu phoosphett grouppukale neekkam cheyth koshatthinte nucleusilekku praveshikkaan anuvadikkunnuvennum tii sell aaktiveshan oonaakkaan bandhamillaattha transcription gadakangalaaya phoos, junn ennivayumaayi pankaalittham pularthunnuvennum avar kaanichu.
harward, raavu, hogan, poost doctoral felomaaraaya yousang gwack, stephaan feske ennivar staanfordile sahapravarthakaraaya richard levis, murally prakriya ennivarumaayi chernnu shareerathile mikka koshangalilum kaalsyam praveshikkunnathinu aavashyamaaya kaalsyam release-activated kaalsyam (crack) chaanalukalude tanmatra aidantitti kandethi. crack chaanal orai 1 encode cheiyunna jeenile mutation moolamaanu paarambaryamaayi rogaprathirodhasheshi kurayunnathennu avar kandethi. enfaatt proteinukal nucleusilekku translocation cheiyunnathil kaalsyam aaktiveshan vahikkunna punk kaaranam rogaprathirodhasheshi kuravaayirunnu, ithu interlookkin-2 polulla saitokin jeenukal ulppedeyulla rogaprathirodha prathikarana jeenukale oonaakkunnu. rogaprathirodhasheshi kuranja rogikalil, orai 1 leeii mutation kaalsyam praveshanathinte poornnamaaya nashtatthinu kaaranamaakukayum kuttikale vividha tharatthilulla anubaadhakalkk vidheyaraakkukayum cheythu.
harwardil ninnu padinjaaran theerathekku maarunnathin thottumunbu, biruda vidyaarthi maamta tahiliani, sahakariyaaya doow. ell. aravind. anchaam bays", 5-hydroxymethylsitione methyl groupine ooksidais cheythukondu jeane expressione mattunna ensaimukalaanu moonnu tettu proteinukalum ennu avar theliyichu, ithu dna demethylation kaaranamaakukayum 5-methylsitosine cytosine upayogichu maattisthaapikkukayum cheiyunnu. laa jola instittyoottil, avarude laab rogaprathirodha samvidaanathinte vividha koshangalilum bhroona vikasana samayathum sariyaaya jeane expressionil tettu ensaimukalude praadhaanyam pradharshippichu. cancer vikasanam adichamarthunnathil, prathyekichu lymphoid, myelooid, mattu hematological maarakathvangalil tettu proteinukalude punk avar eduthukaanichu, koodaathe vitaamin sii polulla tettu aaktivettarukalkku eee hematological maarakathvangalkkulla targettucheytha epigenetic therapy enna nilayil saadhyathakal roopappeduthi.
enfaatt, kaalsyam signalling ennivayilulla deerghakaala thaalpparyatthinte thudarchayaayi ravuvum hogan tii sell ksheenam sambandhichu gaveshanam nadathiyittundu. sahapravarthakarumaayi chernnu, tii-sell exhostion enna padam nirvachikkaan avar pravarthichu, ithu aantijanukal tii-cellukalude amithamaya uthejanam kaaranam rogaprathirodha prathikaranangal kuraykkunnu ennartham varunna avyakthamaayi upayogichirunnu. avarude gaveshanam tumerukalkkullil kaanapedunna tii cellukalil prathyekamaayi shradha kendreekarikkunnu. saadhaarana tii cellukaleppole, oru tumouril thaamasikkumbol kaimerik aantijan resepterukalulla (kaar) tii cellukalum sheenikkunnuvennu avarum avarude sahapravarthakarum theliyichittundu. tii cellukalude ksheenam kuraykkunnathil vishavasthukkalum vishavasthukkalum transcription gadakangalum oru pradhana punk vahikkunnuvennum eee transcription gadakangalude thadassamo thadassamo cancer immunotherapic oru mikacha sameepanamaanennum avar nigamanam cheythu.

