
patrick eiii. bairley

jarmman aasthaanamaayulla molecular biologist, immunologist, professor, biopharmaceutical samrambhakan ennee nilakalil prashasthanaan patrick bairley (jananam november 24,1957). proteinukalude tyrosine sulfation, transcription factor enf-kappab, kyaansar chikilsaykkaayi dvi-nirddishta tii-sell edapazhakunna aantibodikal ennivayude vikasanam ennivayekkurichulla pravarthanatthinu bairley ariyappedunnu.
vidyaabhyaasam.
germmaniyile konstaans sarvakalashaalayil ninnu biologyil diploma nedi. addehathinu piechu labhichu.dii. myoonikkile ludwig maximilian sarvakalashaalayil ninnu biochemistry summa kamm laudil birudam nedi. massatusets instittyoott oof teknolaji, cambridgile whitehead instittyoottil nobal jethaavaaya david baltimorinoppamaayirunu addehathinte poost doctoral pariseelanam.
currier.
thante doktarettu kazhinju, bairley germmaniyile martinsreedile jeane sentarile oru gaveshana samghathe nayichu. 1993ll addeham molecular biology professoraayi, germmaniyile freeberg sarvakalaashaalayile medical faakkalttiyude chairmaanaayirunnu.
1996num 2015num idayil addeham tularic incorperatile mayakkumarunnu kandethal medaaviyaayi sevanamanushtichu.micromet incorporationil cheef scientific offeesaraayi., koodaathe amjen incorporationte vais president research enna nilayilum. germmaniyile myoonikkil.
iomx eji, haarpoon ink, tii. sii. aarr. 2 ink, maverick ink, kalinan ell. ell. sii ennee kambanikalude sahasthaapakanaanu bairley. kembridge aasthaanamaayulla venchwar kyaapittal sthaapanamaaya emm. pii. emm capitalile managing directormaaril oraalaan addeham.
gaveshana pravartthanangal.
tyrosine sulfation.
trans-golji compartmentil cherkkunna srava proteinukalude pathiv parishkkaranamaan tyrosine sulfation ennu 1987 ll bairley kaanichu.
transcription ghadakam enn. eph-kappab.
transcription factor enf-kappab sajeevamaakkunna canonical paatha bairley manassilakkukayum inhibittari subunit aii-kappab, pii65/rila subunit enniva aadyam vivarikkukayum cheythu. vivaadamaaya enf-kappaabinte kandupiduthakkaaril oraalaan bairley ennu parayappedunnu. enf-kappab oru auxidative stress-responsive transcription gadakamaanennu adhehavum samghavum kaanikkukayum naadeevyavasthayil enf-kappaabinte pravarthanaparamaaya punk vivarikkukayum cheythu.
cancer therapy.
relapsed/refractory acute lymphoblastic leukemiyayude chikilsaykkaayi us fda amgeekaricha baitt antibody blinsittom (blinattamomabu; amg 103) vikasippikkunnathin bairley neethrthwam nalkunnu. cancer koshangalude lysisinaayi cytotoxic tii cellukale earppeduthunnathinaayi roopakalppana cheythirikkunna vividha antibody adhishtitha nirmmithikal addeham kandupidichittundu.

