
rebecca abergel

lanthanide actinid complexukalum thammilulla ekopana rasathanthrathil vaidagdhyam nediya oru franch ajaiva rasathanthranjanaanu rebecca abergel. vividha jaiva samvidaanangalil kanatha moolakangalude exposurinteyum malineekaranathinteyum phalangalkkoppam. berkley naashanal laborattariyile kemikkal sciences divisionile faakkaltti shaasthranjanum hevi elament kemistry group leaderumaanu bergell. berkleyile california sarvakalashaalayil nuclear enchineeyaringinte asisttant professor koodiyaanu avar.
aadyakaala jeevithavum vidyaabhyaasavum.
fraansile paareesinaduthaanu abergel valarnnathu, avide 2002 ll ekkol normal superioril ninnu rasathanthrathil biruda birudam nedi. birudadhaariyaayirikke propha. berkleyile california sarvakalaashaalayile ajaiva rasathanthranjanaaya joonn arnold.
thudarnnu avar yuu. sii. berkleyil birudaananthara patanam nadatthi, avide propha. kenn reymond. doctoral padanathinaayi, bakteeriyakal engane irumbu kondupokunnuvennum puthiya irumbu cheletting ejantukal vikasippikkumennum anweshikkunnathinaayi avar siderophore analogukal samanvayippikkukayum savisheshathakal nalkukayum cheythu. 2006ll pii. echu. dii. birudam nedi.dii. rasathanthrathil.
yuu. sii. berkley kemistry departmentum professormaarude group thammilulla samyuktha poost doctoral gaveshakanaayirunnu abergal. fred hutchinson cancer gaveshana kendratthil sakthamaaya rolland. puthiya antibioticukalude vikasanathinaayi "basilus anthrasis" polulla bakteeriyakalil ninnulla siderophorukalumaayi siderocaline engane bandhippikkunnuvennu avar ivide anweshichu.
2009ll berkley labil chernna avarkk 2009ll cooleys anaemiya foundeshanil ninnu oru yuva anweshaka award 2013ll radiation research sosaittiyil ninnu oru juuniyar faakkaltti traval award 2013ll berkley labil ninnu asaadhaaranamaaya shaasthreeya nettatthinulla directorude award labhichu.
gaveshana thalpparyangal.
ekopana rasathanthram, vishakalana rasathanthram, photophysics, biological rasathanthram, aarogya bhauthikashaasthram, farmacology, molecular biology, sell biology ennee mekhalakalil vividha pareekshanangal nadathunnu. kooduthal vyakthamaayi paranjaal, avarude sameepakaala thalpparyangal lanthanideukaludeyum aaktinaidukaludeyum ekopana swabhaavathil shradha kendreekarichu. radionuclydeukalo adhika nuclear charge adangiya aattangalo baadhicha aalukale chikilsikkunnathinulla rogashanti reethikal vikasippikkunnathil avarude samgham prathyekichum sajeevamaan. bio actinide gaveshana samghathinte sameepakaala padanangalil, manushyashareerathile radionuclydeukale surakshithamaayi neekkam cheiyunnathinaayi thiranjeduttha reethiyil bandhippikkaan upayogikkaavunna vividha actinide cheletting ejantukal samanvayippichittundu.
nilavil, radionuclide malineekaranam chikilsikkaan phudu aandu drugg administration amgeekaricha eaka marunnu diethylinetriamine assid (dtpa) (chithram 1) aanu. plutonium vishabaadha chikilsikkunnathil dtpa chila vaagdaanangal kaanichittundengilum eee chikitsa plutoniathinu maathramullathaan. koodaathe, dtpa intravinus aayi nalkanam, ithu radiation vishabaadhayude valare samaya-sensitiivu swabhaavam moolamulla oru prasnamaanu. radiation vishabaadhaykk kooduthal vaividyamaarnnathum eluppathil nalkaavunnathumaaya chikitsa kandethanulla anweshanathil, puthiya tharam chikilsakal vikasippikkunnathil abergel saadhyatha kaanunnu.
naalu cross-linked dipicolinic assid gadakangal adangiya oktadentettaaya ligandaanu anweshanathilulla ejantu (chithram 2). manushyaril vaayiloode upabhogam cheyyaanulla kazhivu eee thanmaathraykk undu. shareerathile visha aaktinaidukalumaayi cheletting ligandaayi ekopippichu avaa ganyamaaya kedupaadukal varuthunnathinumbu ithu pravartthikkum. sidhaanthathil, cheletting ligandukal aaktinaidukalumaayi bandhichukazhinjaal, hevi mettal complexukalkku moothramozhikkunnathiloode swaabhaavikamaayi shareerathil ninnu purathukadakkaan kazhiyum.
oktadentettaaya ghadana kaaranam, thaalpparyamulla chelettar dtpayekkaal "inn vivo" enna lanthanideukalode uyarnna aduppam prakadippikkunnu. athinaal, ithu jeevita samvidaanangalil mikacha radionuclide alankaaram prakadamaakki. ligand plutonium, americium, euranium, neptunium deckerporation ennivaykku anukoolamaaya thiranjeduppu kaanichittundu (manushya koshangalile "inn vitro" parishodhanakalilo elikalude modalukalile "inn vivo" pareekshanangalilo vishaamsham nireekshikkappettilla), ithu nilavil amgeekaricha dtpayekkaal mechappettathaanu. oduvil, oru prathyeka padanatthil, oru marunnayi upayogikkunnathinaayi eee thanmaathrayude vishudhi bergell vilayiruthi, aathyanthikamayi eee sramam vinyasikkaavunna chikitsa parihaaratthinte vikasanathilekku konduvannu.
plutonium illaathaakkunnathil dipicolinic assid adangiya mattu analogukalude falaprapti parishodhikkunnath (chithram 3) ulppedunna oru adhika gaveshana padhathiyaanu abergalinte group. elikalil ezhu divasathe kaalayalavil plutonium neekkam cheiyunnathil rund samyukthangalum vijayichathayi phalangal kaanichu. mothatthil, eee pravartthanavum lanthanide, actinide cheleshan ennivayil shradha kendreekarikkunna kooduthal padanangalum aushadha, paaristhithika rasathanthrathil pradhana prathyaaghaathangal undaakkunnu.