
conypyridoine iii

tibattan peedabhoomiyil kandethiya "koniyocheetta sephalothecoids" enna fungus ulppaadippikkunna tetramic assid derivative aanu conypyridoine iii. eee prakrithidatha uthppannam 0.97 micrometer micro 50 moolyangalulla "staphylococcus ooriyas", "methisilin-resistant staafailokkusooriyas", "enterococcus fecalis" thudangiya vividha bakteeriyakalkkethire aanti baakteeriyal, antifungal pravartthanangal prakadippikkunnathaayi theliyikkappettittund. conipyridoyinte niravadhi analogukalude verthirikkal hahn "mattullavarum" poortthiyaakkiyittundu. antibiotic prathirodhatthe cherukkunnathinulla puthiya antibiotic prakrithidatha uthppannangal kandethunnathinayi.
jaivasamshleshanam.
type I polycatide sintes (pii. keey. ezz) amino assid biogenetic pathayum thammilulla sankarayinamaayaanu conypyridoine iyude jaivasamshleshanam nirddeshikkappettitlathu. asattail-qoo, malonyl-qoo, methylmalonyl-qoo, kaarban shringalayile anubandha pravartthana grouppukale maattaan kazhiyunna niravadhi modular ensimeukal enniva upayogikkunna pii. keey. kalkkaanu decalin bhagam. type aii polycatide sinthesukalkkaayi oru loading modulinoppam aarr advitheeya moduleukal maathrameyulloo. 
conypyridoine iii yude eee mungami biosynthesise cheythukazhinjaal, oru stereospeciphic decalin bhagam nalkunnathinu oru intramolecular dials-alder (aii. emm. dii. eiii) prathikaranam nadakkunnu. aduthathaayi, 1,3-dickettonumaayi cyclisation nadannathinu sesham tetramic assid derivative roopeekarikkaan ell-tyrosine avatharippikkunnu. decalin gadanaykkoppam eee tetramic assid bhaagavum antibiotic pravarthanatthinulla pradhana phaarmakophorukalaanu, mattu niravadhi decalin adangiya antibioticukalil kaanunnu. biosynthesisile avasana ghattangalil regiospeciphic jalamshavum oru isad-oleefin thaangavunna vidhathil illathacal decalin gadanaykkullil oru aalkkeeninte mattoru regiospeciphic kuravum ulppedunnu. decalin, tetraamett gadanakalile eee anthima mattangal conypyridoine iii nalkunnu. pii. keey. ezz prakriyayilekku kooduthal poost-tailoring synthase gattangal ulppeduthunnathiloodeyo decalin, tetramic assid gadanakalilekku eee anthima parishkkaranangal maattunnathiloodeyo eee fangasukalkku niravadhi derivateevukal eluppathil samanvayippikkaan kazhiyum.