
aganirsen

insulin risapttar substrate-1 (aii. aarr. ezz-1) thadayunna 25 merr dii. enn. eiii antisense oligo nucleotide chikilsayaanu aganirsen (munbu jii. ezz-101), ithu okkular neovascularisationulla oru topical chikilsayaayi anweshikkappedunnu. pakarchavyaadhiyaaya keraattaitis, nanavulla praayavumaayi bandhapetta macular degeneration (amd) ennivayulla rogikalil purogamana cornia neovascularisation ulppede kanninte munvashatho (cornia) kanninte pinbhaagatho (rettina) rogangalulla rogikalil ookulaar neovascularisation chikilsaykkulla oru sthaanaarthiyaanu aganirsen.
aii. aarr. ezz-1 emm. aarr. enn. eiii (antisense therapy) bandhippichu aii. aarr. ezz-1-nte ulppaadanathe agaanirsan sajeevamaayi thadayunnu. athinaal agaanirsan neovascularisation paathayude mukalilekkulla thadassam srishtikkunnu, prathyekichu adhika sasyahaaravum ail-1 bitta expression thadayunnathiloode.
ghadana.
aganirsen 25-meter (5 '-ടാറ്റ്സിഗ്ഗാഗ്ഗക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്ക്-3'), aadya thalamura antisense oligo nucleotide (phosphorotheoyate linkej) aanu. aganirseninu 8036 (dii. eiii) tanmatra pindove ekadesham 64.2 digri selshyas dravanaankavum 64 sathamaanam jii. sii ulladakkavumundu. agaanirsan vellathil valare layikkunnu.
pravartthana samvidaanam.
ensaimatik pravartthanam illaatha oru intra sellular docking proteinaan irs-1. neovascularisation avasthakalil endothelial koshangalil aii. aarr. ezz-1 amithamaayi prakadippikkunnu. hypoxia, insulin, veekkam ennivayude madhyasthathayil angiogenesis niyanthrikkunnathinulla lakshyamaayi aii. aarr. ezz-1 nirddeshikkappettittund.
intra sellular pathakalkkulla signal traansmittayi pravartthikkuka ennathaanu aii. aarr. ezz-1-nte pradhana pravartthanam. vejaf-risapttar complexumaayi samvadikkunnathiloode irs-1 pradhaanamaayum angiogenesis paathayumayi samvadikkunnu. athinaal aii. aarr. ezz-1 emm. aarr. enn. eiii. yeei prathyekamaayi lakshyamit sasya, koshajwalana cytokainukalude ulppaadanam thadayunnathiloode agaanirsan angiogenesis kuraykkunnu.
klinikkal vikasanam.
eee marunnu kandethiyathu ezz. alle-mahmoud, fraansile paareesil, pinneedu pakarchavyaadhi keraattaitis rogikalil purogamana cornia neovascularisation moonnaam ghattathilekku vikasippikkukayum cornia graaft maattisthaapikkunnathinu kaathiripp pattikayil (oru yuu. yuu. anatha marunnu padavi) ulppeduthukayum cheythu. coroidal neovascularisationil topical agaanirsante dosine aasrayikkunna prabhavam vettu-emdinte noonn-human primate (enechpi) lazer induced modalilum vilayiruthiyittundu. soriyasisilum aganirsen parishodhikkappettittund, avide kshathatthinte valippam kuraykkunnathu aii. aarr. ezz-1 (pii <0.01), tii. enn. eph. eiii (pii <<aii. dii1>), vascular endothelial valarchaa ghadakam (pii <0.01) ennivayude kuranja prakadanavumaayi bandhappettirikkunnave kandethi.
2007 eprilil, hoost corneyayude (emiya/comp/<aii. dii. 1>) amithamaya neovascularisationumaayi bandhapetta cornia graaft nirasikkal thadayunnathinaayi anatha aushadha uthppannangalkkayulla imayude kammitti (comp) agaanirsanin jeane signal anatha padavi nalki. 2014 eprilil, ischemic central rettina weyin oklooshan (aii. sii. aarr. vii. oo) ennathinu agaanirsanin anatha marunnu padaviyum iii. emm. eiii nalki. kramarahitavum eratta-mask, 3-group, placibo niyantritha trial (sakthamaaya patanam) ischemic crovoic sesham munbhaagathum pinbhaagatthum neovascularisation, neovascular glocoma (enviji) vikasanam ennivayude nirakk kuraykkunnathil marunninte falaprapti vilayiruthunnathinayi europian health dayaraktarettu (efpy-7) funting labhichu.
delivari.
aganirsen topical delivari (aii dropukalum aii emulsion) anweshanathilaanu. muyalukalilum manushyarilum nadatthiya toxicology padanangal velippeduthi, vitharanam cheiyunna eakaagrathayil ninnu swathanthramaayi agaanirsan nannayi sahikkappedunnu.

