
aii. eph. aii. 202

aii. eph. aii. 202 oru mouse jeenaanu (pii202 proteinulla encodeukal). aii. eph. aii. 202 emm. aarr. enn. eyude vardhicha expression levelukalum rogaprathirodha koshangalile pii202 proteente nuclear localisation chila elikalil svayam prathirodhasheshi vikasippikkunnathumaayi bandhappettirikkunnu. athinaal, systemic lupus erythematosus (slee) vikasippikkunnathil jeane ulppettittund. pala tharatthilulla avayavangale aakramikkunnathin kaaranamakunna oru systemic oottoo immyoon rogamaanu slee. pii 200-protein kudumbatthilppetta pii202 proteinaayi ifi202 jeane encode cheiyunnu. type 1 interferon, interferon gaama ennivayaal jeenukalude aii. eph. aii. kudumbam indusible aanu.
vardhicha aii. eph. aii. 202 expression sleep thammilulla bandham aadyam nirddeshichathu rosso mattullavarum aanu. 2001ll. lupessinu samanamaaya lakshanagal kaanikkunna elikalil pleanic bii cellukalil pii202-nte amithamaya aavishkaaram moolamaanu ithu kandethiyathu. nilavil sleeyude prototypical mouse model (enn. ezz. dablyu. ex. enn. ezz. bii) eph 1 aanu, ithu nyoosilaand black, nyoosilaand vaitt elikalude aadya thalamurayude santhathikalkku hraswamaanu. pii202-nte amita uthppaadanam apoptosis prakriyayile oru niyanthrana proteinaaya pii53 protein adichamarthunnathilekku nayikkunnuvennu thonnunnu. ithu urakkathinte chila lakshanangalkk kaaranamaakumenn anumaanikkappedunnu. 
pii202 proteinu inipparayunna gadanayunda
manushyarkk aifi202, aifi204 ennivaykku samanamaaya aifi16 ennariyappedunna oru jeane undu. avaa amino assid shreniyil chila samanathakal pankidunnu.
aii. eph. aii. 202 niyanthrikkunnath aii. ell-6 aanennu ariyappedunnu. aii. eph. aii-6 athinte resepterukalumaayi bandhippikkunnath aaktiveshan staatt 3 (signal transducer transcription 3) lake nayikkunnu, ithu aii. eph. aii. 202-nte padaprayogatthil oru transcription gadakamaayi thonnunnu. aii. eph. aii. 202-ll aii. eph. aii. 202 jeeninte 5 'regulatory mekhalayil oru staatt 3 binding saitt (ezz. bii. ezz) adangiyirikkunnu. p202 expression koshangalude vyaapanathe mandeebhavippikkukayum koshangalude athijeevanam vardhippikkukayum cheiyunnu.
murine genome 1 chromosomilaanu jeane 200 klasttar sthithi cheiyunnathu. elikal urangaanulla saadhyathaykk enba2 locus oru pradhana sambhavana nalkunnuvennu samshayikkunnu. urakkathinte samvedanakshamathayumaayi bandhappettathayi thonnunna aii. eph. aii. 202, aii. eph. aii. 203 enniva enn. bii. eiii. 2 edavelaykkullil ullavayaan. alavu pii. sii. aarr upayogichu, pleanic bii cellukalum noonn-bii/noonn-tii cellukalum sleep celebrity elikalil aii. eph. aii. 202 expression vardhippichathaayi kaanichu. apoptosisinteyum kosha vyaapanathinteyum niyantrakanaanu aii. eph. aii. 202 jeane enna arivinte adisthaanathil, aii. eph. aii. 202 svayam rogaprathirodha rogamaaya sleeyil ulppettirikkunnu.
b6.nba2 lupus sensible elikale mruga maathrkayaayi upayogichu, pleanic bii koshangalude pii53-mediated apoptosis thadayunna aifi202-nte vardhicha aavishkaaram kaanikkan gaveshakarkk kazhinju. propoptotic proteinukalude aavishkaarathin pii53 madhyasthatha vahikkunnuvennu ariyappedunnathinaal, vardhicha pii202 vardhicha pii53 alavukalumayi bandhappettirikkunnu. p53 pravartthanatthe thadayunnathinaayi p202 n-terminal mekhalayile p53 proteinumaayi bandhippikkunnathayi thonnunnu.
p53-nte aavishkaaram iffi202-nte aavishkaarathe thadayunnathaayi thonnunnu. koshangal yuvi prakashavumaayi sanbarkkam pularthiya sesham p202-nte alavu kurayunnu, athesamayam p53-nte alavu vardhikkunnu. koshangalile pii202-nte amithamaya aavishkaaram pii53 mediated apoptosis kurachu.