
mirr-27bii microrna mungamiyaanu

poost transcription thalatthil jeane expression niyanthrikkunna cheria noonn-coding aarenekalaanu micrornakal (mirr). mirr klasttar <aii. dii. 1> angiogenesis niyanthrikkunnu, ithu endothelial koshangal nikshepikkunnathiloode puthiya rakthakkuzhalukal roopappedunna prakriyayaan. endothelial koshangalil rund tharam mirr-27kall kaanapedunnu mirr-27eiii, mirr-27bii. mirr-27kalude yadhaartha samvidaanangal athra parichithamallengilum mirr-27bii-yude amithamaya aavishkaaram angiogenesis vardhippikkunnuvennu padanangal kaanikkunnu. ischemic hrudrogamulla rogikale chikilsikkaan mirr27bii upayogapradamaakumennu eee phalangal soochippikkunnu.
ischemic hrudrogam.
paashchaathya rajyangalil rogaavasthaykkum maranathinum pradhana kaaranam ischemic hrudrogamaanu, eathaanum pathittaandukalude thaarathamyena churungiya kaalayalavil athinte sambhavangal ganyamaayi vardhichu. coronary dhamanikalude thadassam kaaranam, hridayathilekkulla raktha vitharanam vichedikkappedunnu, ithu hridaya peshikalilekkulla aparyapthamaaya rakthavitharanathilekku nayikkunnu, ithu ischemic hrudrogathinu kaaranamaakunnu.
mirr-27 bii, revascularisation.
eee rogamulla rogikalkku vishwasaneeyamaaya chikitsa revascularisation, ithu hridayathilekkulla raktha vitharanam punasthaapikkum.
angiogenesisinte inhibittaraaya semapherine 6ayumaayi mirr-27bii bandhappettirikkunnu. mirr-27bii yude amithamaya aavishkaaram semapherine 6eyude protein expression kurachu, ithu hridayathil puthiya rakthakkuzhalukal mulaykkunnathinu anukoolamaayirunnu. semaphorine 6eiii angiogenesisinte oru inhibittar aanennu kooduthal nirnnayikkaan, sirna upayogichu semaphorine 6eiii nishabdamaakkunnathu rakthakkuzhalukalude roopeekaranathil vardhanavu kaanichu, ischemic hrudrogamulla rogikale chikilsikkaan mirr-27bii upayogapradamaakumennu kooduthal theliyichu.
mirr-27 bii, thrombospondin-1 enniva.
mirr-27bii oru antiangiogenic proteinaaya thrombospondin-1 neey lakshyamidunnu. mirr-27 bii kurayunnathu thrombospondin-1 nte alavu vardhippikkunnu, ithu drosha dieser nishabdamaakkunnathiloode angiogenesis kuraykkunnu. athinaal, thrombospondin-1 adichamarthunnathiloode ischemic hrudrogamulla rogikalil angiogenesis prolsaahippikkaan mirr-27 bii upayogikkaam.