
epithelial sell addition molecule

sii. dii. 326 ennum ariyappedunna epithelial sell addition molecule (epcam), epitheeliyayile caa2 +-indipendant homotypic sell-sell additione madhyasthamaakkunna oru transmembran glycoproteinaanu. sell signalling, migration, proliferation, deferentiation ennivayilum epcam ulppedunnu. koodaathe, sii-mike, iii-fabp, saiklin eiii & iii enniva niyantrikkaanulla sheshiyiloode epcaminu oongoojenik sheshiyund. epitheeliyayilum epithelial-derived neoplaasangalilum maathramaayi epcam prakadippikkunathinaal, vividha arbudangalkkulla diagnostic markeraayi epcam upayogikkaam. tumerigenesisilum carsinomayude metaastaasisilum ithu oru punk vahikkunnathayi thonnunnu, athinaal ithu oru saadhyathayulla roganirnaya markeraayum rogaprathirodha thanthrangalude saadhyathayulla lakshyamaayum pravartthikkum.
avishkaara reethi.
1979 ll aadyamaayi kandethiya epcamine manushya vankudal carsinomayil prabalamaaya uparithala aantijanaayi thudakkathil visheshippichirunnu. pala arbudangalilum ithu vyaapikkunnathinal, ithu palathavana "kandethiyittundu". athinaal epcaminu niravadhi aparanaamangalund, avayil ettavum sradheyamaayathu taxtidy 1 (tumourumaayi bandhapetta kaalsyam signal transducer 1), sidi 326 (klasttar oof deferentiation 326), 17-1 oru aantijan ennivayaanu.
epcam expression manushya vankudal carsinomayil maathram othungunnilla; vaasthavathil, ipkyam vividatharam manushya epithelial tissukal, carcinomakal, poorvvikar, stem cellukal ennivayil prakadippikkunnu. ennirunnaalum, epitheeliyal allatha koshangalilo epitheeliyal allatha uthbhavamulla arbudangalilo epcam kaanapedunnilla. lalithamaaya (prathyekichu grandhikal), suedo-statified, traansishanal epithelia ennivayude basolaattaral membranilaanu epcam prakadippikkunnathu. ithinu vipareethamaayi, saadhaarana schwamous stratified epithelia epcamine sambandhichidatholam negatteevu aanu. vyakthathayude nilavaaram vyakthigatha tissue tharangalkkidayil ganyamaayi vyathyaasappedaam. dahananaalathil, gastric epithelium valare kuranja alavilulla epcam prakadippikkunnu. cherukudalil expression levelukal ganyamaayi kooduthalaanu, koodaathe vankudal epcamile ellah epithelial sell tharangalilum ettavum uyarnna thalathilaanu ithu prakadippikkunnathu.
carsinomayil epcam palappozhum niyanthrikkappedunnum epithelial ithara uthbhavamulla kaansarukalil ithu prakadippikkunnilla. cancer koshangalil, kosha stharathiludaneelam chitharikkidakkunna oru maathrkayilaanu epcam prakadippikkunnathu. ennirunnaalum, carsinomayile epcam expression palappozhum vaividyamaarnnathaanu; oru tumourile chila koshangalkk ore tumourile mattu koshangale apekshichu kooduthal epcam undu.
schwamous carcinomakal palappozhum epcam prakadippikkunnu, athesamayam saadhaarana schwamous koshangal epcam prakadippikkunnilla. vividha tharatthilulla vrukka kosha arbudangalkkidayil epcam expression vyathyaasappedunnu, koodaathe prostettu canceril androjan prathirodham vikasikkumbol epcam expression vardhikkunnu. ivayellaam vividha arbudangalkkulla roganirnaya upakaranamenna nilayil epcaminte upayogathilekku viral choondunnu.
ghadana.
ithu oru sell addition moleculaayi thirichariyappedunnumdum, epu kaamu gadanaaparamaayi sell addition moleculukalude naalu pradhana kudumbangalil onnumaayi saamyamullathalla, athaayath caderine, integrin, selectinukal, immunoglobulin suuppar faamiliyile amgangal.
30 muthal 40 kiloo dii. eiii. vare type aii membran proteinaan epiciam. epcam thanmaathrayude kramam moonnu saadhyathayulla enn-linked glycosylation saittukalude saannidhyam pravachikkunnu. ithu 314 amino aasidukalaal nirmmithamaan. epidermal valarchaa ghadakam (iii. jii. eph) ulla oru extra sellular domaine (242 amino aasidukal)-thyroglobulin aavarthikkunnathupollu domainukal, orotta transmembran domaine (23 amino aasidukal), oru hraswa intra sellular domaine (26 amino aasidukal) enniva eiii. pii. kaamil adangiyirikkunnu. extra sellular domainine chilappol epex ennum intra sellular domainine chilappol epicked ennum vilikkunnu.
pravartthanam.
epu kaaminte krithyamaaya pravartthanam nilavil vyakthamaakkappedunnum epu kaamu niravadhi vyathyastha rolukal vahikkunnathayi kaanapedunnu.
koshangalude chercha.
homotypic sell additionil epcam oru punk vahikkunnathayi aadyamaayi kandethi. ithinartham oru koshatthinte uparithalathile epiciam ayal koshatthile epikyaamumaayi bandhippikkukayum athuvazhi koshangale orumichu pidichunirtthukayum cheiyunnu ennaanu. classic caderine polulla mattu chila addition thanmaathrakalumaayi thaarathamyappeduthumbol epcam madhyasthatha vahikkunna additionukal thaarathamyena durbalamaanu.
intercellulaar addition madhyasthatha vahikkaan epicamk epicade aavasyamaanu; epiciam intercellulaar addition madhyasthatha vahikkukayum epicade vazhi aaktin cytoskelittanumaayi bandhappedukayum cheiyunnu.
caderine-mediated aditionukalil epcam prathikoola swaadheenam cheluthunnu. epcaminte amithamaya aavishkaaram kaadarinte mothatthilulla sellular nilaye maattukayalla, marichu cytoskelittanile caderine/kattanin complexinte bandham kuraykkunnu. epcam expression vardhikkumbol, α-kaatteninte motham alavu kurayunnu, athesamayam sellular β-catenin alavu sthiramaayi thudarunnu.
vividha inn vivo, inn vitro biochemical pareekshanangal trans-interaakshanukal kandethunnathil parajayappettathinaal homotypic pasha pravartthanatthe chodyam cheythittundu. pii. keey. sii signalling, myosin pravartthanam enniva niyantrikkaanulla kazhivinte adisthaanathil badal modalukal vazhi ipkyam proo-addishiv pravartthanam vishadeekarikkaan kazhiyum.
niravadhi epithelial tissuekalile sajeevamaaya vyaapanam vardhichatho "dii novo" epcam expressionumaayi bandhappettirikkunnu. schwamous epithelium polulla epcam expression saadhaaranayaayi illaathatho thaazhnnatho aaya tissuekalil ithu prathyekichum prakadamaanu. epcam eksprashante nila kudal koshangalude vyaapana pravartthanavumaayi bandhappettirikkunnu, avayude vyathyaasavumaayi vipareethamaayi bandhappettirikkunnu.
kyaansaril punk.
epiciam pilarthaan kazhiyum, ithu thanmaathraykk oongoojenik pottensial nalkunnu. villalinushesham, extra sellular domaine (epex) koshathinu chuttumulla pradeshathekku vidukayum intra sellular domaine (eiii. pii. sii. dii) koshatthinte cytoplasathilekku vidukayum cheiyunnu. nucleusinullil fhl2, β-catenin, lef ennee proteinukal ulla oru samuchayam eiii. pii. sii. dii roopappeduthunnu. eee samuchayam pinneedu dnaumayi bandhippikkukayum vividha jeenukalude transcription prolsaahippikkukayum cheiyunnu. sii-mike, iii-fabp, saiklin eiii & iii ennivayaanu appregulationte lakshyangal. ithu tumour valarchaye prothsaahippikkunnathin falamaanu. koodaathe, pilarnna epexinu adhika epiciam thanmaathrakalude pilarppine uthejippikkaan kazhiyum, ithu positteev feedback looppinu kaaranamaakunnu. nucleusile β-kaatteninte alavinu epcaminte expression level modulate cheyyaan kazhiyum.
tumourukalile epithelial messenkymal traansishanil (emt) epcam oru punk vahichekkaam, ennirunnaalum athinte krithyamaaya phalangal shariyaayi manassilakkiyitla. iii-caderine adichamarthaanulla athinte kazhivu soochippikkunnathu epcam amt, tumour metaastaasis enniva prolsaahippikkumennu, ennaal athinte homotypic sell addition gunangalkk iii-caderine adichamarthaanulla athinte kazhivine prathirodhikkaan kazhiyum. vividha padanangalil ninnulla phalangal palappozhum parasparavirudhamaanu. udaaharanathinu, oru padanatthil, hrasvamaaya edapedal rna (sirna) upayogichu epcam nishabdamaakkunnathu vyaapanam kuraykkunnathinum kudiyettatthinum inn vitroyile stanarbuda koshangalude adhiniveshathinum amt prothsaahippikkunnathil epcaminte pankine pinthunaykkunnathinum kaaranamaayi. mattoru padanatthil, eiii. emm. tii. kku vidheyamaakunna koshangal eiii. pii. keey. emmine niyanthrikkunnillenna kandethi. oru padanatthil, epithelial tumours palappozhum epcaminu shakthamayi positteev aayirunnu, ennaal messenkymal tumours idaykkide durbalamaaya posittivitti maathrame kaanichittulloo. amt samayat epcam expression kurachumaathram niyanthrikkappedunnum metaastaasis bhaaviyile tumour saittil athiyukazhinjaal appregulate cheyyappedunnu.
klinikkal praadhaanyam.
rogaprathirodha chikilsayude lakshyam.
saadhaarana epitheeliyayile epcam kooduthalum baasolaattaral membranilaanu prakadippikkappedunnathe, cancer koshatthinte uparithalathil ekathaanamaayi vitharanam cheiyunna cancer tissuevile epcamine apekshichu aantibodikalkk ithu valare kuravaayirikkumennu anumaanikkappedunnu. pala arbudangalilum amithamaayi prakadippikkappedunnathu, cancer stem cellukalil epcam prakadippikkappedunnu, ithu ipkyaamine rogaprathirodha chikilsayude aakarshakamaaya lakshyamakki maattunnu. ennirunnaalum, carsinomayile epcaminte vaividhyamaarnna aavishkaaravum epcamy tumour-nirddishtamallenna vasthuthayum (i.iii.saadhaarana eppitheeliyathil kaanapedunna ithu) epicamilekku nayikkunna immunotheraappi gurutharamaaya paarshwafalangal undaakkumenna aashanka uyarthunnu. cancer sell signalingil epcaminte punk nannayi manassilaakkappedunnathil, ipkyaaminekkaal ipcami signalling chikitsa edapedalinte lakshyamaayirikkam.
adricolomab, catumaxomab, nofettumomabu, mattu monoclonal aantibodikal enniva ithumaayi bandhippikkunnathinaan roopakalppana cheythirikkunnathu.
histopathi.
stanarbudam, vankudal cancer, charmmatthile basel sell cancer ennivayulppede chila kaansarukalil epcam palappozhum amithamaayi prakadippikkunnu. athinaal atharam avasthakalude roganirnayathe epikyaaminulla antibodiyaaya drip 4 upayogichu immunohistokemisro sahayikkaam.
janithaka vaikalyangal.
epcamile oru prashnam parokshamaayi linch syndrome enna janithaka thakaraarin kaaranamakum, ithu kaansarinulla saadhyatha vardhippikkunnu. epcam jeeninte 3 'attatthinte oru bhagam illaathaakkunnathu emech2 jeeninte promoter mekhala hypermethylate cheiyunnathiloode emech2 jeeninte epigenetic nishkriyathaykku kaaranamaakunnu.
navajaathashishukkalil chikilsikkaan kazhiyaatha vayarilakkathinu kaaranamakunna janmana undaakunna tufting entaroppathiyumaayi epcamile mutationukal bandhappettirikkunnu.