chrysotinib

noonn-small sell lung carsinomayude (enn. ezz. sii. ell. sii) chikilsaykkaayi upayogikkunna cancer virudha marunnaan salcori enna brand naamatthil vilkkunna chrysotinib. ithu oru alkku (anaplastic lymphoma kinace), rooss 1 (sii-rooss oongoojen 1) inhibittaraayi pravartthikkunnu. 
medical upayogangal.
metaastaattik noonn-small sell lung cancer (enn. ezz. sii. ell. sii) allengil relapsed allengil refractory, systemic anaplastic large sell lymphoma (aall. sii. ell) chikilsaykkaayi chrysotinib soochippikkunnu.
bhedamaakkaanaavaatha, aavarthichulla, allengil refractory inflammatory anaplastic lymphoma kinace (aalk)-positteev myophybroblastic tumours (imt) ennivayude chikilsaykkum ithu soochippikkunnu.
pravartthana samvidaanam.
chrysotinibinu oru aminopyridine gadanayundu, koodaathe taargett kainaasukalude eiii. tii. pii-binding pokkattinullil mathsaraadhishtithamaayi bandhippikkunnathiloode oru protein kainas inhibittaraayi pravartthikkunnu. cheria koshamallatha shwaasakosha arbudamullah 4 sathamaanam rogikalkkum rogikalkkum ('ekkinoderm microtuble-anubandha protein-like 4'), "alkku" ('anaplastic lymphoma kinace') ennivaykkidayil oru fusion jeane srishtikkunna oru chromosomal punakrameekaranamundu, ithu carsinogenesisinu kaaranamaakukayum marakamaaya phenotype nayikkunnathayi thonnukayum cheiyunna constitutive kinace pravarthanatthinu kaaranamaakunnu. fusion proteininte kinace pravartthanam chrysotinib thadayunnu. eee jeane fusion ulla rogikal saadhaaranayaayi "epidermal groth factor risapttar" jeenil (iii. jii. eph. aarr) allengil "keey-raas" jeenil mutationukal illaatha cheruppakkaaraaya pukavalikkaathavaraanu. alkku"-fusion nslcude puthiya kesukalude ennam yuu. esil prathivarsham ekadesham 9,000 aanu.ezz. lokamembaadum ekadesham 45,000.
"valare cheria kuttikalil maathram sambhavikkunna peripheral nadiviewha arbudathinte apoorva roopamaaya neuroblastomayude ekadesham 15 sathamaanam kesukalilum marakamaaya phenotype nayikkunnathil "alkku" mutationukal pradhaanamaanennu karuthappedunnu.
marakamaaya neoplaasangalude mattu niravadhi hystological roopangalude oongoojenisisil ulppedunna sii-mettu/hepattosaitt groth factor risapttar (echgfr) tyrosine kinesine chrysotinib thadayunnu.
marakamaaya koshangalude valarcha, kudiyettam, adhinivesham ennivayude moduleshaniloode chrysotinib athinte phalangal cheluthumennu karuthappedunnu. marakamaaya tumourukalil angiogenesis thadayunnathiloodeyum chrysotinib pravartthikkumennu mattu padanangal soochippikkunnu.
samoohavum samskaaravum.
niyamaparamaaya padavi.
2011 august 24 nuu yuu.ezz. asaadhaaranamaaya anaplastic lymphoma kinez (alkku) jeane prakadippikkunna chila avasana ghatta (praadeshikamaayi noothanamo metaastaattik) noonn-small sell shwaasakosha arbudangal chikilsikkaan phudu aandu drugg administration chrysotinibinu amgeekaaram nalki. amgeekaarathinu amgeekaarathinu fusion oru companion molecular testt aavasyamaanu. 2016 maarchil yuu.ezz. rooss 1 positteev noonn-small sell shwaasakosha arbudathil phudu aandu drugg administration chrysotinibinu amgeekaaram nalki.
2012 octoberil, europian medisins ejansi (iii. emm. eiii) asaadhaarana anaplastic lymphoma kinace (aalk) jeane prakadippikkunna cheria koshangalallaatha shwaasakosha arbudangal chikilsikkaan chrysotinib upayogikkaan amgeekaaram nalki.
gaveshanam.
shwaasakosha arbudam.
alkku" fusion jeane vahikkunna 82 rogikalil 90 shathamaanathilum tumours churungunnathino sthiratha kaivarikkunnathino chrysotinib kaaranamaayi. chikilsicha 57 sathamaanam aalukalilum tumours kuranjathu 30 shathamaanamenkilum churungi.
avaril mikkavarkkum adenocarcinoma undaayirunnu, orikkalum pukavalichirunnilla allengil muun pukavalikkaraayirunnu. chrysotinib sweekarikkunnathinu munbu avar sharashari mattu moonnu marunnukal upayogichu chikilsaykku vidheyaraakkiyirunnu, 10 sathamaanam maathrame staanderd theraappiyumaayi prathikarikkukayulloo ennu pratheekshichirunnu. aarr maasathe sharashari kaalayalavilekku divasathil randuthavana 250 milligram chrysotinib nalki. eee rogikalil ekadesham 50 sathamaanam perkkum ookkaanam, chharddi, vayarilakkam thudangiya oru paarshwafalamengilum undaayittund. chrysotinibinode chila prathikaranangal 15 maasam vare neenduninnu.
oru ghattam III trial, profile 1007, "alkku"-positteev enn. ezz. sii. ell. sii chikilsayil chrysotinibine staanderd second line chemotherapy (pemetrexed allengil taxoter) thaarathamyam cheiyunnu. koodaathe, randaam ghatta pareekshanam, profile 1005, munkoor chemotherapy onniladhikam varikal labhicha samanamaaya maanadandangal palikkunna rogikalekkurichu padikkunnu.
2016 februvariyil, jeey-alex ghattam III patanam electinibine chrysotinib alkku-positteev metaastaattik enn. ezz. sii. ell. siyumayi thaarathamyam cheiyunnathu neratthe avasaanippichu, kaaranam oru idakkaala vishakalanam kaanikkunnath electinibil purogathiyillaattha athijeevanam kooduthalaanennu. kooduthalaanennu oru vishakalanathilaan eee phalangal sthireekarikkappettathu.
lymphomas.
relapsed allengil refractory alkku + anaplastic large sell lymphoma baadhicha aalukalil, chrysotinib 65 sathamaanam muthal 90 sathamaanam vare vasthunishta prathikarana nirakkum 3 varshathe purogathi rahita athijeevana nirakkum 60-75% uthppaadippichu. chikilsayude aadya 100 divasathinu sesham lymphomayude oru aavarthanavum kanditilla. chikitsa nilavil anischithamaayi thudaranam.
mattu arbudangal.
vipulamaaya neuroblastomayude klinikkal pareekshanangalilum chrysotinib pareekshikkunnund.

