
merii bernheim

merii lilias kristhyan bernheim (munbu muyal; 28 juun 1902-19 november 1997) pinneedu monoamine ooksides ennu punarnaamakaranam cheyyappetta tyramine ooksides enna ensime kandethiyathiloode ariyappedunna oru britiish biochemistaayirunnu. 1928-ll cambridge sarvakalashaalayil doktarettu gaveshanathinide bernheim tyramine ooksidesinte ensime sisttam kandethi, avarude gaveshanam "irupathaam noottaandile neurobiology adisthaana kandethalukalilonn" ennu paraamarshikkappedunnu.
aadyakaala jeevithavum vidyaabhyaasavum.
1902 juun 28 nuu englandile glousestaril merii lilias kristhyan muyal enna peril bernheim janichu. ennirunnaalum, avale chuttumullavar "mollie" ennu vilichirunnu. kuttikkaalathu bernheim valarnnathu indiayilaanu. englandile cambridge sarvakalashaalayil ninnu avar bii. eiii, emm. eiii, phd ennivayil uyarnna birudangal nedi. birudapatanam poortthiyaakkiya sesham, bernheim cambridge sarvakalaashaalayile neunham kolejile biochemistry vibhaagathil phd gaveshanathinaayi baatharst vidyaarthithvam nedi.
monoamine ooksidesinte kandethal.
oru doctoral vidyaarthiyenna nilayil, amino assid tyrosinil ninnu labhikkuna swaabhaavikamaayi undaakunna monoamine samyukthamaaya tyraminte kaattabolisathekkurichu nadatthiya parimithamaaya gaveshanathekkurichu bernheim arinjirunnu. auxidative prakriyakalude vishakalanathinayi puthuthayi mechappeduthiya saankethikavidyakalude labhyatha manassil vechukondu, tyramine cherkkunnath tissuekalile ooksijan ettedukkaline engane baadhichuvennu padikkaan avar theerumaanichu.
avalude jolikkidayil, bernheim muyalinte karal sathil ninnu cavolin cherthu piechu 6.5 ll ensime nedukayum cheythu. ithinethudarnnu, kaattalist diphenylaamainte saannidhyathil tyrosine choodaakkikkondu crude tyramine shekharikkukayum cheythu. verthirichedutha ensime vellathinteyum bufferinteyum saannidhyathil tyraminilekku cherkkukayum tyramine upayogikkunna ooksijante alavu nireekshikkaan barcroft saankethikavidya upayogikkukayum cheythu. tyraminte oro thanmaathrayilum oru ooksijan aattam agiranam cheyyappedunnu enna nireekshanathodeyaanu tyraminte ooksideshan nadannathennu avar kandethi. eee nireekshanam padanavidheyamaaya karal sathil oru ensime sisttathinte saannidhyathe soochippikkunnu, ithu tyramine ooksidesil ulppettirunnathinaal tyramine ooksides ennu bernheim namakaranam cheythu.
ensime sisttathinte kandethalinu purame, bernheim tyramine ooksides sisttathinte niravadhi savishesha gunangal nireekshichu. pareekshanatthil upayogicha methylene neela niram kuranjittillennu avar abhiprayappettu. mattu ensime samvidaanangalil ninnu vyathyasthamayi tyramine ooksides samvidaanathinu dye oru hydrajan sweekarthaavaayi upayogikkaan kazhinjillennu eee nireekshanam soochippichu. koodaathe, eee ensime samvidaanathinullile auxidative prakriya sionide cherkkunnathine prathirodhikkunnathayi kaanapettu. irumbu anthareekshathile ooksijan sajeevamaakkathe nerittulla ooksideshan sambhavikkillenn avakaashappedunna vaarbarginte prasthavanayil ninnu tyramine ooksides samvidaanam oru apavaadamaanennu eee nireekshanam kaanichu. pakaram, sisttam hydrajan peroxide uthppaadippikkunnathayi kaanapettu, ithu sisttathil molecular ooksijan oru hydrajan sweekarthaavaayi pravarthikkunnuvennu soochippikkunnu. ooksideshan prakriyaykoppam tyraminil demination sambhavikkaan ensime sahayichathaayum bernheim kandethi.
avar kandethunnathinumbu, jaivarasaayanika veekshanakonil ninnu tyramine vishadamaayi padikkappettitla.
monoamine ooksides kandethalinte praadhaanyam.
avalude kandethalinethudarnnu, tyramine ooksides tyraminte auxidative demination pradhaanamaanennu bernheim pravachichu, angane kudalukalil ninnu agiranam cheyyappedunna adhika amainukalude vishaamsham illaathaakkaan ithu anuvadikkunnu. monoamine ooksides inhibittarukal upayogichu chikilsikkunna rogikalkku tyramine adangiya bhakshanathinte upabhogathodu vishaparamaaya prathikaranangalundenn kaanikkunna eee pravachanam pinneedulla gaveshanangal sariyaanennu theliyikkapettu. ennirunnaalum, chithratthil kaanichirikkunnathupole catecolamine, histaamain ennivayulppedeyulla adhika monoamine neuro traansmittarukalude auxidative deminationil ensime ulppettittundennu thudarnnulla gaveshanangal soochippikkunnu. ensaimine oduvil monoamine ooksides ennu punarnaamakaranam cheythu, ithu ensime monoamine classile auxidative deminatione uthejippichuvennu soochippikkunnu.
monoamine ooksides (maavo) kandethiyathinushesham, monoamainukalude jaiva praadhaanyam nirnnayikkaan niravadhi padanangal nadatthi. monoamine neuro traansmittarukalude nirjjeevathayil maavoyude praadhaanyam kaaranam, maavoyude pravarthanarahithatha vishaadam, schisophrenia ennivayulppede niravadhi maanasika, neurological vaikalyangalkk kaaranamaakumenn vishwasikkappedunnu. maavo inhibittar iproniasid maanasikavastha uyarthunnathinum athinaal phalapradamaaya aanti-diprasantaayi upayogikkappedunnathinum kaaranamaayathaayi kandethiyappol, monoamine pravartthanam niyanthrikkunna marunnukalekkurichulla pharmacological gaveshanathil ganyamaaya vardhanavundaayi.
vishaadathinte chikilsayil maavo inhibittarukalkku pakaram tricyclic aantidiprasantukalum serotonin reaptekku inhibittarukalum nalkiyengilum, maavoyude pravartthanatthil ippozhum valia thaalpparyamund. vividha maavo upavibhaagangalude kandethal selective maavo upavibhaga inhibittarukalekkurichu gaveshanathilekku nayichu, avaa kuranja paarshwafalangalum prathirodha samayat kooduthal prathyekathayum prakadippikkunnathaayi theliyikkappettittund. eee maavo sub type inhibittarukal geriatric depression chikilsayilum maavo reaptake inhibittarukalkku pakaramaayi upayogikkappedunnu. koodaathe, rakthathile platelettukalil maavo kandethiyirikkunnath maavo pravarthanakshamathayude soochakamenna nilayil platelet ensaiminte pravarthanathekkurichu gaveshanathilekku nayichu.
duke medical school faakkaltti.
1930-ll duke medical skoolinte yadhaartha faakkalttiyil amgamaayi bernheim niyamithanaayi. dukil ninnu thudangiyappol, vidyaarthiyaayo faakkaltti amgamaayo biochemistry vakuppile churukkam chila sthreekalil oraalaayirunnu bernheim. oduvil avar dukil oru phul professoraayi, biruda vidyaarthikaleyum medical vidyaarthikaleyum nazhsing vidyaarthikaleyum padippikkukayaayirunnu. dukile avarude kaalath, medical school klaasukalile sthreekalude ennam ezhupathiyanchu vidyaarthikalulla oru classile onno rando sthreekalil ninnu pakuthiyiladhikam klaasukal ulppedunna sthreekalaayi ganyamaayi vardhichu. 1997-ll marikkumbol, duke medical skoolile yadhaartha faakkalttiyile avasheshikkunna avasana amgamaayirunnu avar.
vyakthiparamaaya jeevitam.
kembridjil aayirikkumbol muyal saha biruda vidyaarthi frederic bernheimine kandumuttukayum oduvil 1928 desember 17 nuu addehathe vivaham kazhikkukayum cheythu. avarude kariyaril, bernheim arupathiladhikam prabandhangal rachichirunnu.
biochemistric appuram, sasyashaasthrathilum parakkalilum bernheim thaalpparyamundaayirunnu. eiii skye oof mye oonn mye oonn" enna pusthakam avar prasidheekarichu, athil avar parakkal mekhalayilekkulla thante yaatra vishadeekarikkukayum oru pailat, flaitt instructor ennee nilayilulla thante anubhavam vivarikkukayum cheiyunnu.
shaasthreeya gaveshanathinu nalkia sambhaavanakalkk bernheim amgeekarikkappedukayum monoamine ooksides kandethiyathin 1975 ll nadanna siba foundeshan simposiyathil avar aadarikkappedukayum cheythu. 1983ll viramichenkilum 1997 november 19nuu 95-aamm vayassil marikkunnathuvare avar adthyaapikayaayi thudarnnu.

