
morphin, anubandha alcaloidukal ennivayude motham samanvayam

rasathanthrathile morphin polulla aalkkaloyidukalude samanvayathil codin, morphin, oripaavin, tebain enniva ulppedunna swaabhaavika morphenon klaas aalkkaloyidukalude motham samanvayavum adutha bandhamullah semi synthetic analogukalaaya methorphan, buprenorphine, hydromorphone, hydrocodone, isocodine, naltrexone, nalbufine, oxymorphone, auxicodon, naloxon ennivayude motham samanvayavum vivarikkunnu.
morphinte ghadana prathyekichu sankeernamalla, ennirunnaalum aduthulla boond aattangalude electrostaattik dhruveekaranam gadanayiludaneelam orepole marunnilla. eee "asambandha connectivity" boond roopeekaranam kooduthal budhimuttaakkunnu, athinaal eee thanmaathrakalude kudumbatthil prayogikkunna eathoru synthetic thanthratheyum ganyamaayi sankeernamaakkunnu.
marshell dii. roopappeduthiya aadyathe morphin motham synthesis. gates, juu. 1952ll motham samanvayathinte vyaapakamaayi upayogikkappedunna oru udaaharanamaayi thudarunnu. eee synthesis motham 31 gattangal edukkukayum mothatthilulla vilavil 0.06% munnott pookukayum cheythu. kenner siyude hydrocodone synthesis. ettavum kaaryakshamamaya arrie 14 ghattangalilayi motham 30 sathamaanam vilavu nedunnu. 9 padikalil, baariyalt root innuvareyullathil vachu ettavum cheruthaanu, ennaal kuranja vilavu nalkunna niravadhi padikal ulkkollunnu, ithu racemic aanu.
evens, futues, parker, ovarmaan, mulser-truner, vaitt, tabber, trost, fukuyama, gillau, storkk, magnus, smith, barrialt ennee gaveshana grouppukal mattu niravadhi synthesisukal report cheythu.
gettu synthesis.
gettsinte morphinte motham synthesis 1925-ll robinson nirddeshicha morphin gadanayude thelivu nalki. morphinte eee synthesis motham sinthasisinte pashchaathalatthil dials-alder prathikaranatthinte aadya udaaharanangalilonnaanu.
arrie synthesis.
arrie synthesis oru biomimetic paatha pinthudarunnu, ithu innuvare report cheyyappettathil vachu ettavum kaaryakshamamaan. morphin biosynthesisil sambhavikkunna rettikulin cyclisation samanamaaya gray cyclisationaanu oru pradhana ghattam.