
ube2vii2

manushyaril "ubv2vii2" jeane encode cheiyunna oru proteinaan ubiquitin-kanjugetting ensime iii2 veriyant 2. iii2 protein kudumbatthile oru prathyeka upakudumbamaanu ubiquitin-kanjugetting ensime iii2 veriyant proteinukal.
ghadana.
ubiquitin-kanjugetting ensaimukalumaayi ubiquitin2vii2-nuu sequence saamyam undengilum iii2-kalude kaattalatik pravarthanatthinu nirnayakamaaya samrakshitha sisttain avashishtangal illa. eee jeane encode cheytha protein ubiquitin-kanjugetting ensime iii 2 veriyant 1, yeest mms 2 jeane ulppannavumaayi homology pankidunnu. 
pravartthanam.
rogakaarikaludeyum koodaathe/allengil paaristhithika sammarddangaludeyum kaalaghattangalil uyarnna alavil kaanapedunna reactive electrophilic speesheesukalude intra sellular sensoraayum ube2vii2 ulppeduthiyittundu. ube2vii2-nte sii69 avashishtangalkk vividha resukalumaayi bandhippikkaan kazhiyum. ube2vii2-maayi rez bandhippikkunnath ube2vii2eiiinean-nte ube2vii2-madhyastha sajeevamaakkal prothsaahippikkunnave theliyikkappettittund, ube2vii2. activated ube2enn-maayi sankeernamaakunna mattoru iii2 protein dna-naashanashta prathikaranangal prothsaahippikkunnathil pradhana punk vahikkunnuvennu theliyikkappettittund. athinaal, rez nerittu sense cheiyunnathiloodeyum dna kedupadukalkkulla prathikaranangale baadhikkunnathiloodeyum ube2vii2 genome samagratha prolsaahippikkum. monocytukaludeyum entocytukaludeyum vyathyaasathilum ithu ulppettirikkaam. 
ashayavinimayam.
ube2vii2 hltfumaayi edapedunnathaayi kaanichittundu. ubiquitin-kanjugetting pravartthanam ubiquitin-kanjugetting pravartthanam illengilum, avayude kaattalatik pravartthanangal sugamamaakkunnathin vividha ubiquitin-kanjugetting ensaimukalumaayi samvadikkaan ithinu kazhiyum. udaaharanathinu, ube2vii2-nuu ube2enn-maayi sankeernamaayi liss-63 linked polyubikvittin shringalakale samanvayippikkaan kazhivulla oru heterodymer roopeekarikkaan kazhiyum. ubiquitin thanmaathraykk onniladhikam saadhyathayulla lysine binding sittukal ullathinaal, prathyekichu lies-63 ll ubiquitin cheyin roopeekaranam prothsaahippikkunnathi yubikvittinte sthaanam ekopippichu yubikvi2enn pravartthanam sugamamaakkam. athupole, vividha substrateukalil lies-63 polyubikvittin shringalakal srishtikkaan kazhiyunna oru sajeeva roopeekaranam sweekarikkaan yuu. bii. sii. 13 neey prerippikkunnathin ubiquitin-kanjugetting ensaimaaya yuu. bii. sii. 13-maayi ubiquitin 2 edapedunnuvennu theliyikkappettittund.
intra sellular taargettukalilekku lies-63 polyubikvittin shringalakal cherkkunnath canonical lies-48 polyubikvittin shringalakalil ninnu vyathyasthamaan, athil lies-63 shringalakal athinte substratinte protesomalile apachayathinu madhyasthatha vahikkunnilla. avayude pravartthanam moshamaayi nilanilkkunnundenkil, lies-63 shringalakal athinte taargett protein pravartthanam sajeevamaakkukayo thadayukayo cheythukondu signalling pathakal niyanthrikkunnuvennu theliyikkappettittund. udaaharanathinu, retroviral reverse-traanscriptionte trim5alfa niyanthranam ube2vii2/yubiiii2എnean-mediated poolii-ubiquitinatione aasrayichirikkunnu. trim21 aantivairal pravartthanatthe samanamaaya reethiyil niyantrikkaan ube2vii2 sahaayikkumenn theliyikkappettittund.

