
joonn eiii. steets

yowan eline aargetsingar steyits (jananam januvari 26,1941) yaale sarvakalaashaalayile molecular biophysics aandu biochemistry sterling professor howard hugues medical instittyoottile anweshakanumaanu. rna ulppedunna kandethalukalude peril avar ariyappedunnu, athil ribosomukal messenture rnaumaayi engane parasparapravartthikkunnu ennathinekkurichulla adisthaanaparamaaya samyojanam ulppedunnu, koodaathe yookkaariyottukalil sambhavikkunna cheria nuclear raibo nucleic proteinukal (snrnps) intronukale vibhajikkunnu. 2018 septambaril medical sayansile prathyeka nettatthinulla lasker-coashland award steets nedi. muun sweekarthaakkalil 87 perkku nobel sammanangal labhichathinaal lasker awardine palappozhum 'american nobal' ennu vilikkunnu.
aadyakaala jeevithavum vidyaabhyaasavum.
minnesotta minnepolisilaanu steyits janichathu. 1950kalilum 60kalilum minnesottayil valarnna avar haiskoolinaayi annathe ool-gales northrop collegiat schoolil chernnu.
1963-ll steyits ohaayoyile antioch collegil ninnu rasathanthrathil baachilar oof sayans birudam nedi, avide alex richinte masaachyusets instittyoott oof teknolaji laboratariyil oru antioch "koppu" inten aayi molecular biologyil aadyamaayi thaalparyam prakadippichu.
biruda birudam poortthiyaakkiya sesham, vanita medical doktarmarekkurichu ariyaamaayirunnuvenkilum vanita shaasthranjarekkurichu ariyaathathinaal steyits biruda skoolinupakaram medical schoolil apekshichu. harward medical schoolil avarkk praveshanam labhichu, ennaal minnesota sarvakalaashaalayile joseph gaalile laboratariyil bench sayantistaayi jolie cheiyunna oru venalkkaalath aaveshabharitharaaya avar harward medical skoolilekkulla kshanam nirasikkukayum pakaram biochemistryilum molecular biologyilum haarvaardinte puthiya prograamil apekshikkukayum cheythu. avide, nobel sammana jethaav jaims vaatsante laboratariyil cherunna aadya vanita biruda vidyaarthiniyaayirunnu avar, avarodoppam avar aadyamaayi bacteriophage rnal pravarthichu.
currier.
steyits kembridge sarvakalaashaalayile medical research kaunsil (emrc) laborattari oof molecular biologyil (elmb) poost doctoral gaveshanam poortthiyaakki, avide avar francis crick, sidani brenner, maarkk breasure ennivarumaayi sahakarichu. emrnal "reeding frame" evide ninnu aarambhikkanamenn baakteeriyakalkk engane ariyaam enna chodyathil elmbyil steyits shradha kendreekarichu. eee prakriyayil, moonnu proteinukal encode cheiyunna oru pakwathayulla rna vairasil krithyamaaya sequenceukal steets kandethi, avide vairas marnah baakteeriyal ribosomukale bandhippichu proteinukal uthpaadippikkunnu. 1969-ll avar binding staartt pooyintukalude nucleotide sequence kaanikkunna "nechar" enna oru seminal paper prasidheekarichu.
1970-ll steyits yaale faakkalttiyil chernnu. 1975-ll, avar oru gaveshana kandethal prasidheekarichu, athil avar parakke ariyappedunnu, emrnayile staartt saitt thirichariyaan ribosomukal complimentary bays pairing upayogikkunnuvennu theliyikkunnu.
1980-ll, maikkal lernerumaayi sahakarichu steyits mattoru nirnaayaka prabandham prasidheekarichu, svayam rogaprathirodhasheshiyulla rogikalil ninnulla manushya aantibodikal upayogichu rogaprathirodhasheshi upayogichu snrnps (snoorps ennu ucharikkappedunnu) verthirichedukkunnathum thirichariyunnathinum spliesingil avayude punk kandethunnathinum. spliciosomukalude oru gadakamaaya puthuthayi transcrib cheytha rna (pree-marnah) yill ninnu intronukale splies cheiyunnathil ulppedunna proteinumaayi bandhapetta ekadesham 150 nucleotideukal neelamulla rnaude oru prathyeka hraswa neelamaanu snrnp. steetsinte prabandham "prakashavarshangalil feeld munnott vekkukayum rna biosynthesisile onniladhikam ghattangalil oru punk vahikkunnathayi kandethiya cheria aarenekalude himapaathathe prakhyapikkukayum cheythu", susanne bergett abhiprayappettu.
marnah spliesing prathikaranangalude oru pradhana nyoonathayil ulppedunna snonp enna mattoru tharam snrnp kanika steyits pinneedu kandethi. snonpsinaayulla jeenukalude janithaka sthaanangalude vishakalanathiloode, palappozhum vivarichathupole intronukal "junk dna" allennu avar vyakthamaayi theliyichu. badal aarr. enn. eiii spliesing" enna prathibhasam vishadeekarikkaan avarude kruthikal sahayikkunnu."snrnpacn snornpineyum kurichulla avalude kandethal oru nigooda kandethal vishadeekarikkunnu manushyarkk oru pazha eechayude erattiyolam jeenukal maathrameyulloo. "ithra kurachu jeenukal maathrame namukk ozhivakkaan kazhiyoo ennathinte kaaranam ningalkk eee viddithangal ullappol avaye vyathyastha reethikalil vibhajikkaan kazhiyum ennathaanu", avar paranju. "chilappol ningalkk eee spliesing prakriya kaaranam karyangal ozhivaakkaanum karyangal cherkkanum kazhiyum, angane oro jeeninum alpam vyathyasthamaaya protein uthppannangal undu, athu alpam vyathyasthamaaya karyangal cheyyaan kazhiyum. athinaal ithu nammude oro jeenukalileyum vivarangalude ulladakkam vardhippikkunnu."
steetsinte gaveshanam lupus polulla svayam rogaprathirodha vaikalyangalude roganirnayatheyum chikitsa kurichu puthiya ulkkazhchakal nalkum, ithu rogikal avarude swantham dna, snrnps allengil ribosomukalkkethire aanti-nuclear aantibodikal nirmmikkumbol vikasikkunnu.
shaasthrathil sthreekalkkethiraaya laingika perumaattathekkurichu steyits abhipraayappettittund, koodaathe "shaasthrathil sthreekalude asraanthamaaya promoter" aanennu kristeen gutri paranju, steyitsine "nammude thalamurayile ettavum mikacha shaasthranjaril oraal" ennu visheshippichu."
medical gaveshanathinaayulla jaine coffin childs memorial fundinte (1991-2002) shaasthra director "jeenukaludeyum vikasanathinteyum" edittoriyal board amgamaayum steyits niravadhi professional padavikalil sevanamanushtichittundu.
vyakthiparamaaya jeevitam.
steyits (jananam joonn aargetsingar) yelile molecular biophysics aandu biochemistry professor 2009 leeii rasathanthrathinulla nobal sammana jethaavumaaya thomas steyitsine 1966 ll vivaham kazhichu. avarkk joonn enna oru makanundu.
avaardukalum bahumathikalum.
royal societyilekkulla avarude naamanirddesham ingane 

