
reactive aldehyde enangal

reactive aldehydeukal ennum ariyappedunna reactive aldehyde speeshees (rasp), saadhaaranayaayi vishaamshamullatho veekkam sugamamaakkunnatho aaya electrophilic oorgaanik aldehyde thanmaathrakalude oru vibhaagathe soochippikkunnu. rasp amine grouppukalumaayum (skiff bays roopeekaranam vazhi) theol grouppukalumaayum (maikkal kootticherkkal vazhi), prathyekichu proteinukalil sahavarthithvathode prathikarikkunnu. electrophyl-responsive proteomumaayi bandhippikkunnathinte paridhi alavukal pinthudarnnu, mapp kinace, protein kinace sii, saitokin releasin veekkathinte mattu vashangalkkum karuthekunna mattu proteinukal ennivayil vivarichirikkunnathu rasp protein pravartthanatthe parishkkarikkunnu. proteinukalumaayi rasp bandhippikkunnath enf-kebi aaktiveshan, autoantibodi roopeekaranam, inflamesom aaktiveshan, scaventure risapttar eiii ennivayude aaktiveshan ennivayilekkum nayichekkaam. aalkkaholukalude ookseekaranam, polyamine metabolism, lipid peroxidation ennivayulppede vividha prakriyakaliloodeyaanu rasp roopappedunnathu. proteinukalumaayum mattu amine allengil theol adangiya thanmathrakalaaya glutathayonumaayum bandhippikkunnathinupura, aldehyde dehydrogenesukal allengil aldehyde reductaseukal vazhi raaspine metabolise cheiyunnu. raaspinte vishaamsham kaaranam, aldehyde dehydrogenesukalile cheria ennam janithaka parivartthanangal maathrame saadhyamaaya santhathikalkku anuvadikkunnulloo, ithu sjogren-laarsan syndrome, sussinic semi-aldehyde dehydrogenase kuravu, mattu apoorva rogangal ennivaykku kaaranamaakunnu.
acrollin, crotonaldehyde, assetaldehyde, hexanel ennivayulppede mattu palathum vivarichittundenkilum, ettavum saadhaaranayaayi report cheyyappedunna rogavumaayi bandhapetta rund proo-inflammatory raaspukal malontialdehyde, 4-hydroxinonal ennivayaanu. mutagenesity, aggregate formation, generalised cytotoxisity enniva raaspinte vishaamshathil ulppedunnu.
udaaharanathinu, aasthma, psoriasis, varanda nethrarogam ennivayulppede niravadhi koshajwalana, svayam rogaprathirodha rogangalumaayi malontialdehyde bandhappettirikkunnu. retinalidehyde, pyridoxal (allengil pyridoxal phoosphett) ennee rund raaspukal maathrame mrugangalil avashya baahyaavishkkaaramallaatha physiological pravartthanangale baadhikkunnulloo, ennirunnaalum vishaamsham thadayunnathinu retinalidehyde protein chaaparonukale valareyadhikam aasrayikkunnu.
klinikkal pareekshanangalil, rasp inhibittar reproxalap pakarchavyaadhiyethara anterior yuvaitis, dry aii disease, allergy kanjankttivittis ennivayulla rogikalil veekkam kuraykkunnathaayi kandethi.