
salvinorine

prakrithidatha raasa samyukthangaludeyum avayude gadanaaparamaaya analogukaludeyum oru koottamaanu salvinorin. salvia divinorum" ennathil ninnu niravadhi salvinorinukal verthiricheduthittundu. avaye dieterpenoid furanolactonukal ennu tharamthirickunnu. vichedikkaavunna falangalulla oru haaloosinojanaanu salvinorin eiii.
niravadhi salvinorinukal verthirichedukkukayum savisheshathakal nalkukayum cheythittundu.
sambhavam.
yadhaarthathil 's' ll ninnu verthirichirikkunnu. divinorum, "saalvinorinukalum cheria alavil kandethunnu
thaarathamyappeduthumbol, salvinorine eiii ins alavu. divinorum "0.89 muthal 3.7 milligram/gram vareyaanu. report cheyyappetta ellah bhinnasamkhyakalum varanda pindatthe adisthaanamaakkiyullathaanu.
rasakaramennu parayatte, mukalil report cheyyappetta enangalkku ivayumaayi athra adutha bandhamilla. divinorum ".
anubandha samyukthangal.
upayogapradamaaya jaiva pravarthanangalkkaayi niravadhi synthetic, semi synthetic analogukal padanathinaayi thayyaaraakkiyittund. ardha-synthetic analogukalil salvinorin bii ethoximethyl eedhar, salvinorin bii methoximethyl eedhar enniva ulppedunnu. poornnamaayum synthetic analogukalil herkinorine ulppedunnu.
salvinorin bii yill ninnu niravadhi derivettukal soukaryapradamaayi nirmmikkam. mikka derivetteevukalum salvinorin eiii pole selective kappa opioid agonistukalaanu, chilath kooduthal shakthamaanenkilum, ettavum sakthamaaya samyukthamaaya 2-ethoximethyl salvinorin bii salvinorin eyekkaal pathiratti shakthamaan. herkinorine polulla chila derivateevukal kappa opioid pravartthanam kuraykkukayum pakaram myoo opioid agonistukalaayi pravartthikkukayum cheiyunnu.
22-theosayanatto-salvinorine eiii athinte pravarthanaparamaaya selectivity kaaranam sradheyamaanu. jidipi-gs parisodhanakalil kopparile salvinorin eyekkaal ezhu madangu shakthamaan 2-methoximethyl salvinorin bii.
divinettorinukal, salvinisinukal ennee klaasukal ulppede mattu niravadhi terpenoidukal "salvia divinorathil" ninnu verthiricheduthittundu. eee samyukthangalonnum kappa-opioid resepteril kaaryamaaya (sub-micromolar) aduppam kaanichittilla, avaa chediyude saiko aaktivittikk kaaranamaakunnu ennathinu thelivukalonnumilla.