frisseld-6

manushyaril "fzd6" jeane encode cheiyunna oru proteinaan frisseld-6 (fz-6).
frisseld' jeane kudumbatthile amgangal 7-transmembron domaine proteinukale encode cheiyunnu, avaa doubluenty signalling proteinukalkkulla resepterukalaanu. eph. isad. dii. 6 proteinil oru signal pepttaid, enn-terminal extra sellular mekhalayile sisttain sambushtamaaya domaine, 7 transmembran domainukal enniva adangiyirikkunnu. ennirunnaalum, mattu pala eph. isad. dii. kudumbamgangalil ninnu vyathyasthamayi, eph. isad. 6-ll sii-terminal pii. isad domaine-binding motif adangiyittilla. eph. isad-6 aanu dablyu. enn. tii 4 ligaandinte risapttar ennu vishwasikkappedunnu.
ashayavinimayam.
fz-6 sravicha frij cheytha protein 1 maayi edapedunnathaayi theliyikkappettittund.
maathrukaa jeevikal.
eph. ex. aii. dii. 3 fangshanekkurichulla padanatthil maathrukaa jeevikal upayogichittundu. 2004-ll, houward hugs medical instittyoottile gaveshakar kaanichathu eph. isad. dii. 6 elikalil mudi paattening niyanthrikkunnuvennum athinte manushya homologue mudi chuzhalukaludeyum kaulikkukaludeyum roopeekaranathil oru punk vahikkunnuvennum. velkkam trastt sanger instittyoottil "eph. eph. sii. aii. dii. 3. tii. emm. 1eiii (comp) dablyu. tii. ezz. aii" enna peril oru vyavasthaapitha nokktu mouse line srishtichu. illaathaakkalinte phalangal nirnnayikkaan aann, penn mrugangal oru staanderd phenotypic screenin vidheyamaayi. adhika screenukal avatharippichu-aazhathilulla rogaprathirodha phenotyping 

