
nothaandrolon

mattu brandukalaaya nilevar, pronabole ennivaykku keezhil vilkkunna norethandrolon, peshikalude valarchaye prolsaahippikkunnathum gurutharamaaya pollal, shaareerika aaghaatham, applaastik anaemiya enniva chikilsikkunnathinum upayogikkunna oru androjan, anabolic steroid (aas) marunnaan, ennaal ithu mikkappozhum nirthalaakkappettu. ennirunnaalum ithu ippozhum fraansil upayogathinu labhyamaan. ithu vaayil ninnaan edukkunnathu.
mukhakkuru, vardhichuvarunna mudi valarcha, shabda mattangal, vardhichuvarunna laingika aagraham thudangiya purushathvathinte lakshanagal norethandroloninte paarshwafalangalil ulppedunnu. draavakam nilanirtthal, sthanangalkk aardrata, purushanmaaril sthanavalarcha, karal kedupaadukal thudangiya eastrogenic efakttukalkkum ithu kaaranamakum. synthetic androjan, anabolic steroid ennivayaanu eee marunnu, athinaal testostiron, dihydrotestostint (dii. echu. tii) polulla androjan resepterukalude (aarr) jaiva lakshyamaya androjan resepterinte (aarr) agonistaanu. athinte androgenic efakttukalumaayi thaarathamyappeduthumbol ithinu sakthamaaya anabolic efakttukal undu. eee marunnin sakthamaaya projestogenic efakttukalum undu.
1953ll kandethiya norethandrolon 1956ll vaidyashaasthraparamaaya upayogathinaayi avatharippikkappettu. anabolic, androgenic efakttukal anukoolamaayi verthirikkunna aadyathe aas aayirunnu ithu. karalinu kedupaadukal undaakumenna aashankayethudarnnu 1980-kalil eee marunnu pinvalichirunnu. athinte medical upayogathinu purame, shareeraghadanayum prakadanavum mechappeduthunnathinna norethandrolon upayogichittundu. pala raajyangalilum eee marunnu niyantritha padaarthamaanu, athinaal vaidyethara upayogam pothuve niyamavirudhamaanu.
medical upayogangal.
peshikalude paazhaakkal, gurutharamaaya pollalukalulla rogikal, gurutharamaaya aaghaathathinu sesham, mattu soochanakalkkoppam chila tharatthilulla applaastik anaemiya ennivaykkulla chikilsayil norethandrolon upayogichittundu.
paarshwafalangal.
norethandroloninte paarshwafalangalil viralisation ulppedunnu. ithinu eestrajanik efakttukal undu, ithu gynaecomastiaykkum draavakam nilanirthunnathinum kaaranamakum. ellah 17α-alkilated aasukalileyum pole, uyarnna alavil norithaandrolon deerghakaala upayogam uyarnna karal ensaimukalum sirosis ulppedeyulla hepatotoxisitic kaaranamaayekkam.
farmacology.
pharmacodynamics.
norethaandrolon oru androjan, anabolic stiroyidaanu, athinaal testostiron, dihydrotestostint thudangiya androjan resepterukalude jaiva lakshyamaya androjan resepterinte agonistaanu. ithinu anabolic-androgenic pravartthanatthinte uyarnna anupaathamund. norethandroloninte 5α-kuranja metabolaittaaya 5α-dihydronerethrolone, 5α-dihydronerethrolone ennivayude kaaryathinu samaanamaayi, norethandrolonumaayi thaarathamyappeduthumbol androjan resepterumaayulla bandham kurayunnu. nothandrolonil nireekshikkunna anabolic-androgenic pravartthanatthinte uyarnna anupathavumaayi ithu bandhappettirikkunnu. aromattes vazhi sakthamaaya eestrajan ethylestradiolilekku parivartthanam cheiyunnathiloode norithandroloninu thaarathamyena uyarnna eastrogenic pravartthanamundu. ithinu sakthamaaya projestogenic pravarthanavumundu. sthreekalil endometrial maattangalude kaaryatthil norethaandroloninte projestogenic shakti norethistaroninu samaanamaan. koodaathe, nothaandrolon hepatotoxic aanu.
pharmacokinetics.
nothandroloninte pharmacokinetics avalokanam cheythittundu.
rasathanthram.
norethaandrolon, 17α-ethyl-19-nortestostin allengil 17α-ethylster-4-enn-17β-ool-3-vann ennum ariyappedunnu, ithu oru synthetic eastrain steroid testostironinteyum 19-nortestostine (nandrolon) 17α-alkilated derivateevumaanu. ithu normethandronumaayum (17α-methyl-19-nortestostin) ethylestrenolumaayum (3-deketto-17α-ethyl-19-nortestostin) adutha bandhamullathaan.
synthesis.
nothandroloninte raasasamshleshanangal prasidheekarichittundu.
charithram.
nothaandrolon jii yill samanvayippichu. dii. 1953-ll serley & kambani, noretthistaron, norettinodral ennivaykkoppam oru projasteenaayi aadyam padichuvenkilum aathyanthikamayi athu vipananam cheythilla. 1955-ll, testostiron polulla pravarthanatthinaayi ithu veendum parishodhichu, testostironinu samanamaaya anabolic pravartthanam undennu kandethi, pakshe androgenic shakthiyude pathinaar bhagam maathrame ulloo. 1956 ll oru aas enna nilayil medical upayogathinaayi avatharippicha norethandrolon, anabolic, androgenic efakttukalude anukoolamaaya verthirivulla aadyathe anabolic steroid allengil aas ennu vilikkappedunna vipananam cheythu. 1957ll oru projasteenaayi normethandrone 1959ll kooduthal ariyappedunna aas nandrolon phenylpropionettum ithine pinthudarnnu. 1950kalude avasaanathil amerikkayil nailevar enna brand naamatthil norethandrolon avatharippikkappettuve 1960kalil parimithamaaya vilppana kaaranam eee rajyath nirthalaakkappettu. europilum mattu chila vipanikalilum ithu avatharippikkappettuve collustatic manjappitham sambandhicha aashankakal kaaranam 1980kalil pala raajyangalilum ithu pinvalikkapettu. innu, marunnu fraansil maathrame labhyamaayittulloo.
samoohavum samskaaravum.
pothuvaaya perukal.
"norethandrolon" ennathu marunninte pothuvaaya peraanu. ithine "norettandrolon", "ethylnandrolone", "ethylnortestostint" ennum athinte vikasana coode naamamaya "sibi-8022" ennum vilikkunnu.
brand perukal.
nilevar, pronabole ennee brand namangalil norethandrolon vipananam cheiyunnu.
labhyatha.
nothaandrolon innu fraansil maathrame labhyamaakoo.
gaveshanam.
purusha hormon garbhanirodhanathil norethandrolon upayogikkunnathinaayi padichittundu.