
chromium (III) picolinate

chromy (III) picolinate ennathu sii. aarr. (sii5echu4enn (qoo2echu)) 3 enna soothravaakyamulla oru raasa samyukthamaanu, saadhaaranayaayi sii. aarr. pii. sii3 ennu churukkipparayunnu. type 2 pramehathe chikilsikkunnathinum sareerabhaaram kuraykkunnathinum ithu oru poshaka supplementaayi vilkkunnu. eee thilakkamulla-chuvapp ekopana samyuktham chromium (III), picolinic assid ennivayil ninnaan uruthirinjathu. saadhaarana aarogyathil insulin glucose upayogikkunnathinu valia alavil chromium aavasyamaanu, ennaal kuravu valare apoorvamaanu, saadhaaranayaayi avarude poshaka aavasyangalil ninnu 100% intravinus aayi sweekarikkunna aalukalil ithu nireekshikkappedunnu, athaayath.iii.motham paarantaral poshakaahaara bhakshanagal. insulin resepterinte samvedanakshamatha vardhippichu insulin niyanthrikkunnathaan chromium ennu thiricharinjittundu. manushya pareekshanangalil ninnulla parasparavirudhamaaya thelivukal kaaranam athinte falaprapti vivaadamaayi thudarunnundengilum, type 2 pramehathinulla chikilsayaayi chromium (iii) picolinate nirddeshikkappettittund.
charithram.
1989-leeii oru patanam soochippikkunnathu chromium (iii) picolinate sareerabhaaram kuraykkaanum peshikalude pindam vardhippikkaanum sahaayikkumenn, ithu chromium (iii) picolinate supplementukalude upayogam vardhippikkunnathinu kaaranamaayi, athinte falamaayi ithu kurachu kaalathekku kaalsyathinu pinnil ettavum vyaapakamaayi upayogikkunna randaamathe supplementaayi maari. 2013 leeii oru cochrain avalokanathinu atharam avakaashavaadangale pinthunaykkunnathinaayi "uracha theerumaanangal ariyikkunnathinulla vishwasaneeyamaaya thelivukal" kandethaan kazhinjilla. kooduthal insulin resepterukal uthppaadippikkunnathina emrnaude pravartthanam neettunnathiloodeyo uthppaadanam niyanthrikkunnathiloode insulin samvedanakshamatha mechappeduthunnuvennu gaveshanangal pothuve theliyichittundu.
parivartthana lohangalil, poshaka moolyathinteyum vishaamshathinteyum kaaryatthil ettavum vivaadaparamaayathaanu sii. aarr. 3 +. eee vivaadam sii. aarr. 3 + enthengilum poshakagunangal nalkunnundo ennathine kendreekarikkunnu. koodaathe, sii. aarr adangiya jaiva thanmathrakalkkonnum avayude ghadana savisheshamallennathum pravartthana reethi nirnnayikkappedaathum eee vivaadam vardhippikkunnu. glucose mettabolisatthil oru punk vahikkunna sii. aarr. 3 + kandethiyathilekku nayicha aadya pareekshanam "glucose tolerance factor" enna proteinil lohathinte jaivashaasthraparamaayi sajeevamaaya roopam nilanilkkunnuvennu nirddeshichu, ennirunnaalum, puthiya thelivukal soochippikkunnathu ithu ottappedal nadapadikramangalil ninnu labhicha oru karakaushalavasthuvaanennu. chromium (iii) supplementation motham paarantaral poshakaahaaratthil aalukalkk nalkumbol undaakunna lakshanangalude vipareethamaanu chromium kuravinte eaka amgeekritha soochakam.
bhauthika raasa gunangal.
1917ll aadyamaayi report cheyyappetta pink-chuvapp samyukthamaanu chromium (III) picolinate. ithu vellathil moshamaayi layikkunnu, neutral piechil 600 micrometer vellathil layikkunnu. mattu chromium (III) samyukthangalkk samaanamaayi, ithu thaarathamyena nishkriyavum prathikarikkaathathumaanu, athaayath eee samuchayam anthareeksha saahacharyangalil sthirathayullathum samyukthathe vighadippikkaan uyarnna thaapanila aavasyamaanu. kuranja piechu thalatthil, complexes hydrolyse cheyth picolinic assid swatantra sii. aarr. 3 + umm purathuvidunnu.
ghadana.
chromium (iii) picolinettinu vikalamaaya octahedral jyaamithiyund, ithu cobalt (iii), manganese (iii) ennivayude samaghadanayaanu. chromium (III) oru haard levis aasidaan, athinaal carboxylate ooksijanumaayi uyarnna aduppavum picolinettinte pyridine naitrajanumaayi idatharam aduppavumundu. oro picolinate ligand oru bidendate cheletting ejantaayi pravartthikkukayum sii. aarr. 3 + nte + 3 charge nirveeryamaakkukayum cheiyunnu. sii = enn vibrationte ir spectrayile swatantra picolinic aasidinu 1602.4 centimeter −1 ennathil ninnu chromium (iii) picolinettinu 1565.9 centimeter −1 ennathilekku maarunnathil ninnaan pyridine naitrajanilekkulla cr3 + sentar kordinettukal varunnathennathinte thelivukal. picolinettile pyridine valayathinte naitrajan aattavum sii. aarr. 3 + umm thammilulla bondinte neelam <aii. dii. 1> muthal <aii. dii. 2> vare aayirikkum. picolinate ligand deprotonate cheyyumbol maathrame sii. aarr. 3 + lake coordinate cheiyunnulloo, ithu carboxyl functional groupil yathaakramam oo-echu stretchingin bendingin anusrithamaayi 2400 muthal 2800 centimeter −1 (2500 centimeter −1 ll kendreekarichirikkunnu), 1443 centimeter −1 vareyulla aii. aarr baandukal aprathyakshamaakunnathiloode vyakthamaan. koodaathe, eee ir shift soochippikkunnathu picolinate kordinettukalude carboxylatil ninnu sii. aarr. 3 + kendrathilekku oru ooksijan aattam maathrame ulloo. sii. aarr-oo bondinte neelam <aii. dii. 1> muthal <aii. dii. 2> vare aayirikkum. kristtal ghadana aduthide 2013 ll maathrame vivarichittulloo. vellam sii. aarr. 3 + kendravumaayi ekopippikkunnilla, pakaram mattu sii. aarr. (pii. sii) 3 complexukal thammilulla hydrajan bondaayi kanakkaakkappedunnu, ithu sii. aarr. (pii. sii) 3 complexukalude oru shringhala roopappeduthunnu.
kromiyathinte biochemistry (iii) picolinate.
rakthathile glucosinte alavu saadhaarana nilayilaayirikkunnathinu oru avashya pooshakamaayi chromium thiricharinjittundu, athinaal, shareerathinullil kaanapedunna rund swaabhaavika thanmaathrakalumaayi ithu edapedumennu nirddeshikkappedunnu. cr (iii) thanne oru haard lohamayathinaal aspaarttett, glutamate thudangiya haard ligandukalumaayulla ekopanathiloodeyaanu eee edapedalukal sambhavikkaan saadhyatha kooduthal.
chromium agiranam cheyyukayum visarjjikkukayum cheyyuka (iii) picolinate.
chromium (iii) picolinate kazhichu aamaashayathilekku praveshichukazhinjaal, aamaashayathile mucosayumaayi sanbarkkam pulartthumbol complexinte acidity hydrolysis sambhavikkunnu. jalavisleshithamaaya sii. aarr. 3 + hexakwa roopathil kaanappedukayum cherukudalinte kshara piechil ethiyaal layikkaatha sii. aarr. (iii)-hydroxide-ooksaid (ghraana prakriya) roopappeduthukayum cheiyunnu. krominte ekadesham 2 sathamaanam krominte kudal vazhi agiranam cheyyappedunnu (3) aparyapthamaaya nishkriya gathaagathatthiloode picolinate cheiyunnu. agiranam kuravaanengilum, mattu jaiva, ajaiva srothassukalekkaal (athaayath, sii. aarr. pii. sii. 3) kooduthal kaaryakshamamaayi agiranam cheiyunnu.iii. sii. aarr. sii. ell. 3, chromium nikkottinett) enniva tissuekalil uyarnna saandrathayil adinjukoodunnu. mattu chromium (iii) supplementukale apekshichu chromium (iii) picolinettinte oru pradhana vilppana kendramaanithu. kooduthal lipophilic aaya ligaandukal ullathinaal jaiva srothassukal nannayi agiranam cheyyaan pravanatha kaanikkunnu, ithu saadhaaranayaayi lohathinte chaarjine nirveeryamaakkunnu, angane kudal stharathiloode eluppathil kadannupokaan anuvadikkunnu.
bhakshana gadakangal sii. aarr. 3 + agiranam cheiyunnathine baadikkunnuvennum theliyikkappettittund. annajam, lalithamaaya panchasaara, ooksaalik assid, chila amino aasidukal enniva chromium agiranam cheiyunnathinte nirakk vardhippikkunnu (iii). hexakwa sii. aarr. 3 + neey kooduthal lipophilic roopangalilekku parivartthanam cheiyunna ligand cheleshante falamaanithu. ithinu vipareethamaayi, kaalsyam, magneeshyam, titanium, sink, vanadium, irumbu enniva agiranam cheiyunnathinte nirakk kuraykkunnu. orupakshe, eee ionukal puthiya loha-ligand santhulithaavastha avatharippikkunnu, angane sii. aarr. 3 + nuu labhyamaya lipophilic ligand pool kurayunnu. rakthapravaahathilekk agiranam cheyyappedumbol, crpc 3-ll ninnulla cr 3 +-nte 80 sathamaanavum transferinilekku kaimarunnu. release cheiyunnathinte krithyamaaya samvidaanam nilavil anjjaathamaanu, ennirunnaalum, ithu sambhavikkunnillenn vishwasikkappedunnu, effe3 + lennapole, sii. aarr2 + nte uyarnna asthiratha kaaranam. 10 muthal 100 microgram/kilogram vare sareerabhaaramulla ellah koshangalilum nalkunna sii. aarr. 3 + kaanapedunnu. ithu pradhaanamaayum moothrathil (80 sathamaanam) visarjjikkappedunnu, backie viyarpilum malatthilum visarjjikkappedunnu.
transferrin chromium (III) bandhippikkunnu.
chromodulinu purame transferrin oru pradhana physiological chromium transport ejantaayi thiricharinjittundu, ennirunnaalum aduthide nadanna oru padanatthil sii. aarr. 3 + yadhaarthathil transferrin oru mettal ayoon transport ejantaayi pravartthikkunnathil ninnu apraapthamaakkunnuvennu kandethi. transferrin ferric ionukalkku valare prathyekathayullathaanenkilum, saadhaarana saahacharyangalil, transferrin thanmaathrakalude 30 sathamaanam maathrame ferric ionukalaal poorithamaakoo, ithu mattu lohangalkk, prathyekichu valia charge-tuu-sais anupaathamullavaykku, bandhippikkaan anuvadikkunnu. binding saittukalil sii-lobum enn-lobum adangiyirikkunnu, avaa ghadanayil eathaandu samaanamaan. oro lobilum aspartic assid, histidin, 2 tyrosine avashishtangal, oru bicarbonate ayoon enniva adangiyirikkunnu, ithu irumbineyo mattu lohangaleyo vikruthamaaya octahedral jyamithiyil traansfarinumaayi bandhippikkaan anuvadikkunna oru bidentate ligandaayi pravartthikkunnu. transferrin enna rasavasthuvumaayi sii. aarr. 3 + bandhippikkunnathine pinthunaykkunna thelivukal ferritin, upavaasa glucose, insulin, glycated haemoglobin (echbi 1essy) ennivayude alavu enniva thammilulla nalla parasparabandham kaanikkunna vipulamaaya klinikkal padanangalil ninnaan varunnath. koodaathe, elikalil nadatthiya oru inn vivo padanatthil, istopic aayi sii. aarr. 3 + ennu label cheytha 80 sathamaanam traansfarinil avasaanichathaayum bakkiyullava albumin aanennum kandethi. chromy (III) chloride otappetta transferinilekku cherkkumbol, yuvi-vis spectrathile mattangal kaaranam sii. aarr. 3 + eluppathil bandhippikkappedunna traansfarinaanennu oru inn vitro patanam kaanikkunnu. sii-lobile sii. aarr. 3 + nte formation sthiraangam 1.41 x 1010 mee − 1 umm enn-lobile 2.04 x 105 mee − 1 umm aanu, ithu sii-lobine sii-lobine mungananayode bandhippikkunnuvennu soochippikkunnu. mothatthil, chromium (III)-nte roopeekarana sthiraangam ferric ayoninekkaal kuravaanu. bicarbonate saandrata valare kuravaayirikkumbol bicarbonate ligand sii. aarr. 3 + bandhippikkunnathil nirnaayakamaan, bicarbonate bandhavum ganyamaayi kuravaanu. electron paramagnetic resonance (iii. pii. aarr) padanangal kaanikkunnath piechu 6 nuu thaazhe, chromium (iii) enn-lobumaayi maathram bandhippikkunnu, neutral phinode aduthu, chromium (iii) sii-lobumaayi bandhippikkunnu. saachureshan 30 sathamaanathiladhikam koodumbol sii-lobumaayi bandhippikkunnathin chromium (iii) ferric ionumaayi malsarikkum. traansfarinil amithamaya irumbu saachureshan ulla irumbu sambharana rogamaaya hemochromatosis ulla rogikalil maathrame eee phalangal kaananakoo.
pravartthana samvidaanam.
kuranja tanmatra bharamullah chromium-binding padaartham (elmdablucr; chromeduline ennum ariyappedunnu) shareerathil chromium (III) bandhippikkunnathayi thonnunna oru oligopeptaidaanu. naalu amino assid avashishtangal ithil adangiyirikkunnu; aaspaartett, sisttain, glutamate, glycine, naalu (sii. aarr. 3 +) kendrangalumaayi bandhippichirikkunnu. tyrosine kinace paathaye uthejippikkunnathiloodi kinace pravartthanam neettikkond ithu insulin resepterumaayi samvadikkukayum glucose agiranam mechappeduthunnathilka nayikkukayum cheiyunnu. ithu glucose tolerance gadakavumaayi aashayakkuzhappathilaayittund. chromoduline swabhaavasavisheshathakal nalkaanulla sameepakaala sramangal nadannittum, krithyamaaya ghadana ippozhum thaarathamyena anjjaathamaanu.
insulin resepteril chromodulinte krithyamaaya pravartthana samvidaanam nilavil anjjaathamaanengilum, saadhaaranayaayi vivaricha oru samvidaanam chuvade avatharippikkunnu. eee nirddishta samvidaanathinu chromeduline ulppedunna vividha pareekshanangalumayi ettavum kooduthal karaarund.
saadhaaranayaayi, chromoduline apochromoduline roopathil nilanilkkunnu, ithu sii. aarr. (iii) ionukal illaathathum insulin resepterukalil kuranja pravarthanamullathumaanu. nucleusile insulin sensitiivu koshangalilanu apochromoduline sambharichirikkunnath. rakthathile glucosinte alavu uyarumbol, insulin rakthapravaahathilekk purathuvarikayum insulin resepterinte oru baahya α-subunitumaayi bandhippikkukayum cheiyunnu, ithu oru transmembran proteinaan. insulin resepteril 2 extra sellular α-sabyoonittukalum 2 transmembran β-sabyoonittukalum adangiyirikkunnu. insulin insulin resepterumaayi bandhippichaaludan, resepteril oru roopabhedam sambhavikkunnu, ithu 3 tyrosine avashishtangalum (β-sabyoonittukalil sthithicheyyunnu) phosphorylate cheyyaan kaaranamaakunnu. ithu resepterine sajeevamaakkukayum insulinil ninnu koshatthilekku signal kaimaran anuvadikkukayum cheiyunnu.
mukalil soochippichathupole, agiranam cheyyappetta chromium (iii) picolinate oduvil traansfarinil sii. aarr. 3 + upekshikkunnu. ithaakatte, transferrin sii. aarr. 3 + insulin sensitiivu koshangalilekku (athaayath.iii. adiposaittukal) apochromadulinumaayi bandhippichu holochromaduline roopappedunnu. holochromaduline insulin resepterumaayi bandhippikkunnu, ithu kainesukalude kinace pravartthanam neettunnathiloodeyo insulin risapttar emrnaude alavu niyanthrikkunnathiloode insulin resepterinte sajeevamaaya roopeekaranam nilanirthaan sahayikkunnu, angane rakthathile glucosinte alavu kuraykkunnu.
irs-1 nte tyrosine phosphorilation, elviated threy308, serr 473 phosphorilation oof aakdiyude mechappetta alavu, vividha sellular, mruga modalukalil piai3-keey pravartthanam vardhippikkal ennivayil ninnu thelinjathupole, aiaarinte thaazhekkulla thanmaathrakale baadhikkunnathiloode insulin-uthejippicha insulin signal transduction niyantrikkaan kromiyathinu (iii) kazhiyumennu pareekshanangalkk kaanikkan kazhinju. vardhicha irs-1 phosphorylation insulin risapttar censitivity vardhippikkunnathinu kaaranamaayi, athesamayam ekediyum paii 3-keyum kosha uparithalathilekku glute 4 translocation vardhippikkunnathinu kaaranamaayi, angane glucose kooduthal ettedukkaan kaaranamaakunnu.
endoplasmic rettikulam (iii. aarr) sammarddam kuraykkunnathiloode chromium (iii) insulin prathirodham laghookarikkumennum theliyikkappettittund. err lumenil thettayi madakkiyathum thurannathum aaya proteinukalude shekharanamaayaanu err stress nirvachichirikkunnathu. irr stress sii-juun terminal kainesinte (jnk) uthejanathilekku nayikkunnu, ithu irsinte serin avashishtangale phosphorylate cheiyunnu, ithu insulin signalling cascade adichamarthunnathilekkum glucose upabhogam kuraykkunnathilekkum nayikkunnu. chromium sammarddathe thadayunnuvennum athinaal insulin signalling adichamarthunnathu uyarnnuvarunnuvennum pareekshanathmaka kandethalukal soochippikkunnu. krithyamaaya samvidaanam anjjaathamaanu.
insulin resepterinte kinace pravartthanam deerghippikkunnathinulla mattoru maarggam protein-tyrosine phosphatase 1 bii (pidipi 1 bii) yill oru nirnaayaka sajeeva saitt sisttain avashishtatthinte ooksideshan aanu. saadhaaranayaayi, pii. tii. pii. 1bii defosphorylate phoosphett groupil athinte sisttain avashishtangaliloode nucleophilic akramanam nadatthi phosphoterosine avashishtangal nirjjeevamaakkunnu, angane insulin resepterine nirjjeevamaakkunnu. eee prakriya tyrosine avashishtangalil ninnu phoosphett groupine neekkam cheyth oru sis-ezz-poow 32-group roopappeduthunnu, athu pinneedu sisttain avashishtathe punarujjeevippikkunnathi vellathaal jalavishleshanam cheyyappedukayum mattoru ghatta pravarthanatthinu anuvadikkukayum cheiyunnu. chromium (iii) vaasthavathil pidipi1biyude maattaanaavaatha thadassathinu kaaranamaakumenn gaveshanangal theliyichittundu. sii. aarr (aii. aii) sii. aarr (vii) allengil sii. aarr (vii) (ooksidooredaktesukalude pravartthanatthiloode) aayi parivartthanam cheyyappedunnuvennu karuthappedunnu, athu pinneedu pidipi 1biyile sisttain avashishtatthinte theoline sulphenic aasidaayi ooksidais cheiyunnu, thalphalamaayi phosphotyrosine phoosphett groupine akramikkaan kazhiyilla. ennirunnaalum, ithu vishwasaneeyamaaya oru samvidaanam maathramaan, eee sidhaanthathe pinthunaykkunnathinu nerittulla thelivukalonnum kaanichittilla.
signal cascade oof cheyyumbol, holochromoduline moothrathil ninnu neekkam cheyyappedunnu, kaaranam roopeekarana sthiraangam sii. aarr (aii. aii) nerittu neekkam cheyyaan kazhiyaathathra valuthaanu. carbohydrate adangiya bhakshanam kazhichathinu sesham moothrathile chromium saandrata vardhikkunnathumaayi koshangalil ninnulla chromeduline nashtappedunnathu bandhappettirikkunnave pareekshanathmaka thelivukal theliyichittundu (athaayath.iii. glucose).
aarogyaparamaya avakaashavaadangalum samvaadangalum.
sareerabhaaram.
athlattukalude shareeravikasanathinulla sahayamaayum sareerabhaaram kuraykkaanulla margamaayum chromium (iii) picolinate amerikkayil vipananam cheythittundu. avalokanangal onnukil peshikalude valarchayilo kozhuppu nashtappedunnathilo oru phalavum illennu report cheythittundu, allengil 12 aazhchayil kooduthal neenda pareekshanangalil mithamayathum ennaal sthithivivarakkanakusaricha praadhaanyamullathumaaya-1.1 kilogram (2.4 poundu) sareerabhaaram kuraykkunnu. europian bhakshya suraksha authority saahityam avalokanam cheyyukayum oru avakaashavaadathe pinthunaykkaan mathiyaya thelivukalillennu nigamanam cheyyukayum cheythu.
prameham.
chromium supplementationte picolinate roopam insulin prathirodham kuraykkaanum glucose metabolism mechappeduthaanum sahaayikkunnuvenn avakaashavaadangalundu, prathyekichu type 2 prameharogikalkku, ennaal avalokanangal prameharogikalkku chromium, glucose allengil insulin saandrata enniva thammil oru bandhavum kanikkunnilla, prameharogikalkku anischithamaaya phalangal. type 2 prameha rogikalil chromium picolinate echu. bii. eiii 1 sii alavu 0.7 sathamaanam kurachathaayi randaamathe avalokanathinte rachayithakkal paraamarshichu, mosham gunanilavaaramulla padanangal uyarnna nilavaaramulla padanangalekkaal valia nalla phalangal nalkunnuvennu avar nireekshichu. mattu chromium adangiya bhakshana supplementukalumaayi thaarathamyappeduthumbol rakthathile glucosinte alavu kuraykkunnathinu chromium (iii) picolinate kooduthal phalapradamaakumennu rund avalokanangal nigamanam cheythu.
2005ll yuu.ezz. insulin prathirodhavum type 2 pramehathinulla saadhyathayumaayi bandhapetta bhakshana supplementaayi chromium picolinettinulla yogyathayulla aarogya claim phudu aandu drugg administration (fda) amgeekarichu. atharamoru avakaashavaadam unnayikkaan aagrahikkunna eathoru kambaniyum krithyamaaya vaakkukal upayogikkanam "oru cheria patanam soochippikkunnathu chromium picolinate insulin prathirodhatthinte saadhyatha kuraykkumennum athinaal type 2 pramehathinulla saadhyatha kuraykkumennum soochippikkunnu. ennirunnaalum, chromium picolinettum insulin prathirodhavum type 2 pramehavum thammilulla atharamoru bandhatthinte nilanilpp valare anishchithathvathilaanenna fda nigamanam cheiyunnu."harji avalokana prakriyayude bhaagamaayi, asaadhaaranamaayi uyarnna rakthathile panchasaara, hridayasambandhamaaya asukhangal, rettinoppathi allengil vrukkarogathinulla saadhyatha enniva kuraykkunnathinulla mattu avakaashavaadangal fda nirasichu. chromium (iii) picolinate upabhogavum insulin prathirodhavum thammilulla bandham valare anishchithathvathilaanu" ennu 2006-ll fda koottichertthu.
padanangalude vyathiyaanam.
type 2 pramehatthinte mathiyaya chikilsayumaayi chromium (iii) picolinate bandhapetta klinikkal phalangalil sthiratha nireekshikkappettilla. klinikkal padanangalil pankedukkunna rogikalude glucose asahishnuthayude alavaanu ithinu kaaranam. glucose asahishnutha oru gradiantaanu, athinte theevrathaye vamseeyatha, ponnathadiyude alavu, praayam, shareerathile kozhuppinte vitharanam ennivayum mattu niravadhi gadakangalum badhikkunnu. chila padanangalil, supplementinte kuranja alavu nalkiyittundenkilum, insulin prathirodhatthinte vyathyastha alavukal kaaranam glucosinte alavil ganyamaaya kuravundaakunnathinu munbu oru vyakthikk anuyojyamaaya alavil chromium (iii) picolinate nalkanam. paraamarshikkenda mattoru pradhana kaaryam prameham ellaayppozhum glucose asahishnutha moolamalla undaakunnath ennathaanu. neratthe soochippichathupole, sii. aarr. (iii) glucose asahishnuthaye maathrame swaadheenikkunnulloo, insulin alavilalla. koodaathe, padanangal nadatthiya anthareeksham sthirathayullathaayirunnilla. sammarddathinte thoth, rogikal kazhikkunna bhakshanakramam, rogiyude janithakashasthram enniva patana vishayangalil vyathyaasappettirikkunnu. insulin pravartthanatthe badhikkunna kromiyathinte phalangal kuraykkaan kazhiyunna vaividhyamaarnna prameha virudha marunnukal upayogichu pramehamullavare ithinakam chikilsichirunna vividha padanangalkkidayilulla niyanthranangalude kaaryatthilum ithu sariyaanu. eee prameha mrugangale niyanthrana groupinaayi prameha virudha marunnukal upayogichu chikilsikkaathathinaal mruga padanangal kooduthal nalla phalangal nalkunnathu enthukondaanennu ithu vishadeekarikkum. koodaathe, agiranam, visarjjana vibhaagathil soochippichathupole, chromium (iii) picolinettinte agiranam/jaiva labhyatha bhakshanathe swaadheenikkunnu. eee vyathyastha gadakangal mothatthil padanangalile vyathiyaanathin kaaranamaayittund.
surakshithathvavum vishaamshavum.
mattu tharatthilulla trithwa kromiyangale apekshichu chromium (iii) picolinate dna kedupaadukalkkum mutation undakkaan saadhyatha kooduthalaanenna praadhamika aashanka uyarnnuvenkilum eee phalangalum charcha cheyyappedunnu. chromium (iii) picolinate supplementation chromosomal vyathiyanangal srishtikkukayum santhathiyude vikasanathe thadassappeduthukayum vandhyathaykkum marakamaaya mutationukalkkum kaaranamaakukayum cheiyunna fruit eechakalile padanangale adisthaanamaakkiyullathaayinu eee aashankakal.
manushyaril sii. aarr. (iii) picolinettinte vishaamsham vilayiruthunnathinayi oru patanam prasidheekarichu. eee patanam nadatthiya gaveshakar, naadh allengil sisttain polulla sellular reductantukal vazhi sii. aarr (iii) sii. aarr (ii) aayi kurayunnu enna muun arivu upayogichu. sii. aarr. (ii)-nte eee kuranja roopam echu2oo2-maayi prathipravartthichu radical speesheesukal srishtikkunnathaayi kaanikkunnu, athu dna bays jodikale ooksidais cheiyunnu. eee arivu manassil vechukondu, gaveshakar ettu aazhchathekku oru divasam 400 microgram chromium (iii) picolinate upayogichu patthu sthreekalkku nalki. antibody titerukal upayogichu 5-hydroxymethyl yooraasilinte alavu alakkunnathiloode, chromium (iii) picolinettumaayi nerittu bandhappett sambhavikkunna dna bays jody ooksideshante alavu groupinu anumanikkaan kazhiyum. chromium (iii) picolinate thanne vivoyil kaaryamaaya chromosomal kedupaadukal varuthillennu padanatthinte phalangal soochippikkunnu.
pothuve paranjaal, chromium (iii) picolinate manushyarkk vishamallenn theliyikkappettittund. mikka muthirnnavarkkum ithu prathidinam 1000 microgram vare dosukalil vaayiloode edukkaam. eee kuranja vishaamsham saadhaaranayaayi shwaasakoshathiloodeyum charmmatthiloodeyum dahananaalathiloodeyum shareerathil sii. aarr (aii. aii) yude kuranja agiranam, uyarnna visarjanam ennivayumaayi bandhappettirikkunnu. saadhaaranayaayi, edutha chromium (III)-nte 99 sathamaanavum upayokthaavinte malam veendedukkaan kazhiyum. vrukka thakaraarilekku nayikkunna chromium (iii) supplementationte otappetta sambhavangal undaayittund, ennirunnaalum eee bandham vyakthamalla, ithuvare pareekshichittilla.
chromium (iii) picolinettinte niyanthranam.
2004ll, yuke phudu staanderds ejansi chromium (iii) picolinettinu munganana nalki mattu tharatthilulla trithwa chromium upayogikkaan upabhokthaakkale upadeshichu, mutagenesity kammittiyil ninnu specialist upadesham labhikkunnathuvare. chromium (iii) picolinate genotoxic (cancerinu kaaranamaakunnu) aayirikkaamenna vitaaminukaleyum daathukkaleyum kurichu vidagdha samgham unnayicha aashankakal kaaranamaan ithu. eee supplement moolamundaayirikkaavunna vrukka thakaraarinekkurichulla rund cases reportukalum kammitti shradhikkukayum athinte surakshayekkurich kooduthal gaveshanam nadathanamennum aavasyappettu. 2004 desemberil, mutagenesity kammitti athinte kandethalukal prasidheekarichu, "mothatthil daattayude balance soochippikkunnathu chromium (iii) picolinate inn vitro allennu kanakkaakkanamenn", "chromium (iii) picolinate ulla sasthanikalil labhyamaya inn-vivo parisodhanakal negatteevu aanennu" nigamanam cheythu. eee kandethalukalethudarnnu, yuke phudu staanderds ejansi chromium (iii) picolinate ozhivakkaanulla upadesham pinvalichu, ennirunnaalum chromium saplimentukalekkurichu upadesham avalokanathil sookshikkaan padhathiyundu.
2010ll, chromium (III) picolinate bhakshana supplementukalil upayogikkaan health canada amgeekarichu. amgeekritha labeling prasthaavanakalil iva ulppedunnu nalla aarogyam nilanirthunnathinulla oru ghadakam, aarogyakaramaya glucose mettabolisathinu pinthuna nalkunnu, carbohydrateukale metabolis cheyyaan shareerathe sahayikkunnu, kozhuppukale metabolis cheyyaan shareerathe sahayikkunnu.