tripsin inhibittar

oru tripsin inhibittar (tiai) oru protein oru tharam serin protees inhibittarum (serpin) aanu, ithu proteinukalude sajeevamakkalum kaattalatik prathikaranangalum niyanthrikkunnathiloode tripsinte jaiva pravartthanam kuraykkunnu. manushyarilum monogastrics, yuva roominantukal thudangiya mattu mrugangalilum dahanathinte bhaagamaayi niravadhi vyathyastha proteinukalude thakarchayil earppettirikkunna oru ensaimaanu tripsin. tripsin inhibittarukal ulppedeyulla serpinukal thirichedukkaan kazhiyaathathum aathmahathyaa substrate polulla inhibittarukalaanu.
ithu tripsinte ghadanaye vinaashakaramaayi maattukayum athuvazhi dahana prakriyaykkayi proteinukalumaayi bandhippikkaan ithu labhyamaakaathirikkukayum cheiyunnu. thalphalamaayi, dahana pravartthanatthe thadassappeduthunna protees inhibittarukalkku poshakaviruddha falamundu. athinaal, tripsin inhibittarukal oru aanti-nutritional factor allengil enn. eph. aayi kanakkaakkappedunnu. koodaathe, tripsin inhibittar chimotrypsin pravartthanatthe bhaagikamaayi thadassappeduthunnu.
trypsinogen tripsinte nishkriyamaaya oru roopamaanu, athinte nishkriyamaaya roopam shareerathinte protein vashangalaya pancreas, peshikal enniva thakarunnillenn urappaakkunnu. ithu pancreasil roopappedukayum enteropeptidase upayogichu trypsinilekku sajeevamaavukayum cheiyunnu, ithu kaimotripsinte nishkriya roopamaanu, koodaathe tripesin pole samanamaaya pravarthanangalumundu.
tripsin inhibittarinte saannidhyam valarcha vaikunnathinum upapachayam, dahana rogangal ennivaykkum kaaranamaakumenn kandethiyittundu. koodaathe, tripsin inhibittar upabhogathil pancreatic hypertrophy oru saadhaarana sambhavamaan, oru uthppannathil tripsin inhibittarinte saannidhyam protein karyakshamatha kuraykkunnu, athinaal upabhokthru sareerathinu protein kaaryakshamamayum poornnamaayum upayogikkaan kazhiyilla.
pravartthanam.
soyabean, daanyangal, daanyangal, vividha adhika payarvarggangal thudangiya vividha bhakshanangalil tripsin inhibittar adangiyirikkunnu. eee bhakshanangalile tripsin inhibittarukalude pradhana pravartthanam oru prathirodha samvidaanamaayi pravartthikkuka ennathaanu. eee doshakaramaaya ghadakam adangiyirikkunnathiloode tripsin inhibittar adangiyirikkunna eathoru bhakshanavum ozhivaakkenda bhakshanamaanennu vanyamrugangal manassilakkunnu. sasyathinullile jaiva prakriyakalkkum tripsin inhibittar athyaavasyamaanu.
tripsin inhibittar swaabhaavikamaayum kannukaalikal polulla enangalude pancreasilum sambhavikkam. trypsinogen koodaathe/allengil chemotrypsinogen ennivayude eathenkilum aakasmika sajeevavalkkaranathil ninnu mrugathe samrakshikkuka ennathaanu ithinte pravartthanam.
nishkriyathvam.
tripsin inhibittar choodu labyl aanu, athinaal eee bhakshanagal choodil thurannukaattunnathiloode tripsin inhibittar neekkam cheyyukayum bhakshanam pinneedu kazhikkaan surakshithamavukayum cheiyunnu. soyabean 14 minitt thilappikkunnathu inhibittarinte 80 sathamaanavum 30 minittinaayi 90 sathamaanavum nirjjeevamaakkunnu. uyarnna thapanilayil, iii.jii. presher kukkarukalil, paachakam cheiyunna samayaparidhi kuravaanu. nediya nirjjeevathayude alavu alakkaan elisa testtukal upayogikkaam.
vaanijya vyavasaayangalile prayogangal.
tripsin inhibittarinte ettavum pradhanappetta prayogam kannukaalikalude theettayaanu. kannukaali theettayile oru janapriya gadakamaanu soyabean, athinaal soyabeanil tripsin inhibittar ullathinaal ithu oru aashankayaan. kannukaali theettayil upayogikkunna soyabeanil bhooribhaagavum soyabean bhakshanamakki maattukayum eee prakriyayiloode choodu chikitsa kaaranam tripsin inhibittar neekkam cheyyukayum cheiyunnu. ennirunnaalum, sajeevamaaya tripsin inhibittar kazhikkunna mrugangalekkurichu pareekshanangal nadathiyittundu, avaa sthiramaayi bharam kurachittundu.
shudhajala nathayaaya "pomeshya canaliculata" yude muttakalil ninnulla oru protees inhibittar, saadhyathayulla vettakkaarude proteesumaayi oru tripsin inhibittaraayi edapedunnuvennu velippeduthunna oru patanam 2010 ll report cheyyappettu, ithu mrugaraajyathile eee samvidaanathinte aadya nerittulla thelivaanu.
klinikkal praadhaanyam.
pepttaid tumourumaayi bandhapetta tripsin inhibittar (taatti) musinus ooveriyan carcinoma, eurothelial carcinoma, renal sell carcinoma ennivayude adayaalamaayi upayogichittundu. vrukkakal vazhi upapachayam cheyyappedunna taatti vrukka thakaraarulla rogikalil uyarnna nilayilaanu. pancreatitis polulla neoplastic ithara prakriyakalil ithu uyarthappedaam, eee krameekaranatthil oru pravachana markeraayi upayogikkaam (70 microgram/lii nuu mukalilulla alavu mosham roganirnayavumaayi bandhappettirikkunnu).
onnaam ghattatthile musinus ooveriyan kaarsinokalude ambathu sathamaanavum uyarnna taattiyumaayi bandhappettirikkunnu, naalam ghattatthile tumourukalude eathaandu 100% uyarnna tattiyumaayi bandhappettirikkunnu.
enpathiyanchu muthal 95 sathamaanam vare pancreatic adenocarcinomakal vardhichuvarunna taattiyumaayi bandhappettirikkunnu (ennaal paankriyaattaitisile uyaram eee krameekaranatthil taattiyude klinikkal upayogathe parimithappedutthunnu; mukalil kaanuka).
arupath sathamaanam gastric adenocarcinomakalum uyarnna taatti kaanikkunnu, prathyekichu defusely inflagrative/signet ring tharatthilulla tumours. athinaal, vayarile kudal tharam adenocarcinomayil maathram uyarthunna zee. iii. eiii. ykku taatti poorakamaanu.
eurothelial carsinomayil, thaatti expression ghattam anusarichu vyathyaasappedunnu, thaazhnna ghattathilulla tumourukalil 20 sathamaanam muthal uyarnna ghattathilulla tumourukalil 80 sathamaanam vare.
vrukkakosha arbudathinte krameekaranatthile taatti censitivity ekadesham 70 sathamaanamaanu. uyarnna thalatthilulla rogamulla rogikalil uyarnna thaatti kaananulla saadhyatha kooduthalaanu.
padicha mikkavarum ellah tumour tharangalilum, mosham roganirnayathinte adayaalamaanu taatti.

