
baloxavir marboxyl

influvensa eiii, influvensa bii ennivayude chikilsaykkulla oru aantivairal marunnaan sophlusa enna brand naamatthil vilkkunna baloxavir marboxyl. 2018 ll jappanilum amerikkayilum vaidyashaasthraparamaaya upayogathinaayi ithu amgeekarikkappedukayum ithu orotta dosaayaanu vaayiloode edukkukayum cheiyunnathu. ithu influvensa lakshanangalude dairkhyam ekadesham oru divasathekku kurachekkaam, pakshe athu phalapradamallaatha prathirodhasheshiyulla myoottantukalude thiranjeduppinu saadhyathayund.
baloxavir marboxyl oru produg strattajiyaayi vikasippicheduthu, athinte metabolism sajeeva ejantaaya baloxavir assid (bxa) purathuvidunnu. baloxavir assid pinneedu ensime inhibittaraayi pravartthikkunnu, influvensa vairasinte cap-dependent endonuclease pravartthanatthe lakshyamidunnu, ithu vairasinte polymerase complexes "cap snatching" cheyyaan upayogikkunnu, ithu athinte jeevithachakrathinu athyanthaapekshithamaaya oru prakriyayaan.
vayarilakkam, bronchitis, ookkaanam, sinasitis, thalavedana ennivayaanu baloxavir marboxyl ettavum saadhaaranamaaya paarshwafalangal.
yuu. ezz phudu aandu drugg administration (eph. dii. eiii) baloxavir marboxyline oru phastt-inn-klaas marunnayi kanakkakkunnu.
medical upayogangal.
48 manikkooril kooduthal eee anubaadhayude lakshanagal prakadippicha panthrand vayaso athil kooduthalo praayamulla vyakthikalkkulla oru influvensa marunnaaya oru aantivairalaan baloxavir marboxyl. 48 manikkoorinusesham nalkunna baloxavir marboxyl falaprapti pareekshichittilla.
2019 octoberil, influvensa sankeernathakalkku saadhyathayulla panthrand vious athil kooduthalumulla aalukalil theevravum sankeernamallaathathumaaya influvensayude chikilsaykkaayi oru update cheytha soochanaykku fda amgeekaaram nalki.
2020 novemberil, influvensa ulla oru vyakthiyumayi sanbarkkam pularthiya sesham panthrand vious athil kooduthalumulla aalukalkk influvensa (influvensa) yude poost-exposure prathirodham ulppeduthunnathinulla oru update cheytha soochanaykku fda amgeekaaram nalki.
2022 augustil, influvensa ulla oru vyakthiyumayi sanbarkkam pularthiya sesham anchu vious athil kooduthalumulla aalukalkk influvensa (influvensa) yude poost-exposure prathirodham ulppeduthunnathinulla oru update cheytha soochanaykku fda amgeekaaram nalki.
europian yooniyanil, baloxavir marboxyl sankeernamallaatha influvensayude chikilsaykkum panthrand vious athil kooduthalumulla vyakthikalil influvensayude poost-exposure prophylaxisinum soochippikkunnu.
labhyamaya foomukal.
baloxavir marboxyl gulika roopathilum vellathil kalarthunnathinulla kanikakalaayum labhyamaan.
prathirodham.
randaam ghatta pareekshanatthil baloxavir sweekarthaakkalil 2.2 sathamaanavum moonnaam ghatta pareekshanatthil baloxavir sweekarthaakkalil ekadesham 10 sathamaanavum, polymerase proteente vakabhedangal isolucin-38, prathyekichu, aii38tii, aii38emm, allengil aii38eph mutationukal ennivaykku pakaramaayi pradarshippikkunnathinaal, anubaadhayulla influvensa vakabhedam marunninodu prathirodham nediyirunnu. eee marunninodulla chikithsayodulla prathikaranamaayi sweekarthaakkalil prathyakshappedunna prathirodhathekkurichulla gaveshanavum klinikkal ashankayum thudarukayaanu.
ethirvashangal.
paalulppannangal, kaalsyam fortified paneeyangal, allengil poshakangal, antaasidukal, kaalsyam, irumbu, magneeshyam, selenium, aluminium allengil sink adangiya ooral supplementukal ennivaykkoppam baloxavir marboxyl nalkaruth.
paarshwafalangal.
baloksavir marboxyl otta doses nalkiyathinethudarnnulla saadhaarana paarshwafalangalil vayarilakkam, bronchitis, jaladosham, thalavedana, ookkaanam enniva ulppedunnu. baloxavir sweekarichavaril 21 sathamaanavum placibo sweekarichavaril 25 sathamaanavum oseltaamivir sweekarichavaril 25 sathamaanavum prathikoola sambhavangal report cheythu.
pravartthana samvidaanam.
influvensa vairasinte cap-dependent endonucles pravartthanatthe lakshyamitulla oru ensime inhibittar, prathyekichu, vairas polymerase complexinte pravarthanangalilonnaaya influvensa therapic ejantaanu baloxavir marboxyl. prathyekichum, ithu cap snatching ennariyappedunna oru prakriya thadayunnu, athiloode hoost sell rna traanskripttukalil ninnu hraswavum pothinjathumaaya primerukal vairas uruthirinjedukkunnu, athu athinusesham aavashyamaaya vairal emrnakalude polymerase-catalised sinthasisinaayi upayogikkunnu. oru polymerase subunit hoost pree-marnakalumaayi avayude 5 'kyaappukalil bandhippikkunnu, thudarnnu polymerasinte endonucles pravartthanam "10-13 nucleotideukalkku sesham" athinte pilarppine uthejippikkunnu. athinaal, athinte samvidaanam oseltaamivir, sanamavir thudangiya neuraminidase inhibittarukalil ninnu vyathyasthamaan.
rasathanthram.
oru polycyclic kudumbatthinte pakarakkaranaaya pyridon derivative aanu baloxavir marboxyl, athinte rasasamshleshanam sheonogi aandu qoo enna kambani palavidhatthil report cheythittundu. jappaanile (athupole mattullavayum); 2016 num 2019 num idayil japanese pettant saahithyathil sheonogi reportukal niravadhi thavana prathyakshappettittundu, ithu upayogathilundaayekkavanu saadhyamaaya vyaavasaayika synthetic roottukalekkurich ulkkaazhcha nalkunnu.
baloxavir marboxyl (bxm) oru prodragaanu, athinte sajeeva ejantaaya baloxavir assid (bxa) athivegam "inn vivo" aayi purathuvarunnu, kaaranam baloxavir marboxyl jalavishleshanam cheiyunnathu cherukudalinte raktham, karal, lumen ennivayude koshangalile arilasettamide deesettilesukal vazhi uthejippikkunnu. sheonoggy mattullavarum (yunaittad stetts datheduttha peru (yusan) nalkunnathinumumbu) kandethiya samayathum vikasanathilum prasidheekaranangalil upayogichirunna baloxavir marboxyl, baloxavir assid ennivayude samyuktha samkhyakal yathaakramam ezz-033188, ezz-033447 ennivayaayirunnu. pettant saahithyathinte avalokanathil report cheythathupole, prodraginte carbonic assid esttar (carbonate) bhagam-mukalilulla chithratthinte thaazhathe idathu moolayil kaanichirikkunnu-chloromethyl methyl carbonate upayogichu chikitsa nalkikkond avasana gattamaaya 2-hydroxy-4-pyridon mungamiyil ninnulla kandethal, vikasana gaveshanathinide thayyarakki.
charithram.
2018 septambar vareyulla kanakkukal prakaram, kramarahitavum niyantrithavumaaya moonnaam ghatta pareekshanatthinte eaka reportil, baloxavir oru placibo chikitsa grouppumaayi thaarathamyappeduthumbol aarogyamulla pankaalikalil influvensa lakshanangalude dairkhyam ekadesham oru divasam kurachu, ithu oru oseltaamivir chikitsa groupil kandathumayi thaarathamyappeduthaavunnatha. pankedukkunnavarude chikitsa groupil baloxavir aarambhichathin sheshamulla aadya divasam, oseltaamivir allengil placibo grouppukalile pankaalikalekkaal vairal looad kuranju; ennirunnaalum, anchu divasathinu sesham, baaloksaavirinte orotta dosinte vairal loadle ninnulla prabhavam athinte chikitsa groupile oseltaamivirinte poornnamaaya, 5 divasathe rejimene thudarnnu nireekshicha phalatthil ninnu verthirichariyaan kazhinjilla.
sheonogi qoo aanu baloxavir marboxyl vipanikkayi vikasippichath.oru japanese farmaceutical kambaniyum swittsarland aasthaanamaayulla roche ejiyum. sheonogi gaveshana reportingil baloxavir marboxyl, baloxavir assid enniva yathaakramam ezz-033188, ezz-033447 ennee perukalil kaanapedunnu.
samoohavum samskaaravum.
niyamaparamaaya padavi.
sankeernamallaatha influvensa (trial 1,1518t0821, trial 2, nct02954354) ulla muthirnnavarilum pediatric pankaalikalil nadatthiya rund klinikkal pareekshanangalil ninnulla gunangaludeyum paarshwafalangaludeyum thelivukalude adisthaanathil jappaanile aarogya, thozhil, kshema manthraalayavum (jmldablue) us phudu aandu drugg administration (fda) baloxavir marboxyl amgeekarichu. rund pareekshanangalilum klinikkal saittukalum jappaanile pankaalikalum ulppedunnu, trial 2 amerikkayil klinikkal lokkeshanukal cherkkunnu.
2018 februvariyil jappanil baloxavir marboxyl vilppanaykku amgeekaaram nalki. 2018 octoberil, 48 manikkooril kooduthal rogalakshanangalillaatha panthrand vious athil kooduthalumulla aalukalil sankeernamallaatha influvensayude chikilsaykkaayi fda ithu amgeekarichu. baloxavir marboxyl ennathinte fda apekshaykku amerikkayil munganana avalokanam nalkukayum sheonogi & kambanikku sofluesayude amgeekaaram nalkukayum cheythu., limittad. 2018 octoberil, prathyekichu, influvensayumaayi bandhapetta sankeernathakal undakanulla uyarnna apakadasaadyathayulla aalukalkkaayi baloxavir marboxyl upayogikkaan fda amgeekaaram nalki. 2019 octoberil, influvensa sankeernathakalkku saadhyathayulla panthrand vious athil kooduthalumulla aalukalil theevravum sankeernamallaathathumaaya influvensayude chikilsaykkaayi oru update cheytha soochanaykku fda amgeekaaram nalki. 2020 novemberil, influvensa ulla oru vyakthiyumayi sanbarkkam pularthiya sesham panthrand vious athil kooduthalumulla aalukalkk influvensa (influvensa) yude poost-exposure prathirodham ulppeduthunnathinulla oru update cheytha soochanaykku fda amgeekaaram nalki.
2020 februvariyil austreliyayil vaidyashaasthraparamaaya upayogathinaayi baloxavir marboxyl amgeekarichu.
otta ooral dosai edukkunna aantivairal marunnaaya baloxavir marboxyl-nte surakshyum falapraptiyum 1,832 vishayangalude rund kramarahithamaya niyantritha klinikkal pareekshanangalil pradharshippichu, athil pankedukkunnavare flue lakshanagal anubhavappett 48 manikorinullil baloxavir marboxyl, oru placibo allengil mattoru aantivairal flue chikitsa enniva sweekarikkaan niyogichu. rund pareekshanangalilum, baloxavir marboxyl upayogichu chikilsikkappedunnavar placibo eduthavarkku rogalakshanangal laghookarikkaan kuranja samayamaayirunnu. randaamathe pareekshanatthil, baloxavir marboxyl sweekarichavarum mattu influvensa chikitsa labhichavarum thammilulla lakshanagal laghookarikkunnathinu samayathil vyathyasamonnum undaayirunnilla.
poost-flue exposure prathirodhatthinaayi baloxavir marboxyl surakshyum falapraptiyum oru kramarahitavum eratta-andhavum niyantrithavumaaya pareekshanam pinthunaykkunnu, athil 607 vishayangal, panthrand vious athil kooduthalumullavar, avarude veettil influvensa baadhicha oru vyakthiyodu sanbarkkam pularthiyirunnavarkku onnukil baloxavir marboxyl allengil oru plaasiboyude orotta doses labhichu. eee 607 vishayangalil 303 perkku baloxavir marboxyl, 304 perkku placibo enniva labhichu. influvensa vairas baadhichavarum paniyum kuranjathu oru shwasana lakshanamenkilum 1 muthal 10 vare prakadippichavarumaayavarude anupathamaayirunnu pareekshanatthinte praadhamika anthima pooyint. baloxavir marboxyl sweekarichavaril 1 sathamaanam perr eee maanadandangal paalichu, klinikkal trialinu placibo labhicha 13 sathamaanam vishayangalumayi thaarathamyappeduthumbol.
2021 januvariyil europian yooniyanil vaidyashaasthraparamaaya upayogathinaayi baloxavir marboxyl amgeekarichu.