tii. sii. 1/marainer

tii. sii. 1/mariner ennathu interspersed repeatus dii. enn. eiii (klaas II) transposonukalude oru classes suuppar faamiliyumaan. eee varggathile gadakangal manushyar ulppede ellah mrugangalilum kaanapedunnu. prottistukalilum bakteeriyakalilum iva kaanapedunnu.
ettavum nannayi padicha rund amgangalude perilaanu eee klaas ariyappedunnathu, "synorhabditis elegansinte" tii. sii. 1 traansposan, "drosophilayude" marainer traansposan.
ghadana.
transposonil oru transposase jeane adangiyirikkunnu, rund terminal inverted repiyettukal (tirr) undu. insertinte iruvashathum rund short tandom saitt duplicationukal (tsd) undu. rund transposesukal tirr sequenceukal thirichariyukayum bandhippikkukayum orumichu cherukayum dna double-strand pilarpp prolsaahippikkukayum cheiyumbozhaanu transposition sambhavikkunnath. dna-transposase complexes athinte dna cargo genome mattevideyengilum nirddishta dna motifukalil cherkkunnu, ithu samyojanathil hraswa tsdkal srishtikkunnu. gadakamaaya/tii. sii. 1/mariner sisttathil, upayogichirikkunna motif oru "taa" daine nucleotidaanu, ithu ulppeduthiyathinu sesham iruvashathum pakartthunnu.
transposase jeane traansposon vahikkaathappol, athu svayambharanaadhikaaramillaathi maarunnu, kaaranam ippol jeane mattevideyengilum prakadippikkendathundu.
transposase cheyyuka.
360-amino assid polypeptidinu moonnu pradhana sub domainukalundu transposoninte mirror cheytha ir/dr sequenceukalile dr seekwansukalumaayi bandhippikkunnathin utharavaadiyaaya amino-terminal dna-recognission domaine, oru nuclear localisation sequence (enls), transposition ulkkollunna katt-aandu-pesttu prathikaranangalude koottatthe uthejippikkunna oru dde domaine. dna-thirichariyal domaine dnaumayi bandhippikkaan kazhiyunna rund "jodiyakkiya" boxes sequenceukalundu, avaa chila transcription gadakangalil kaanapedunna vividha roopangalumaayi bandhappettirikkunnu; rund "jodiyakkiya" boxukalkku paii, chuvapp ennu label cheythittundu, iva randum dna-binding domainukalkku pothuvaaya helix-teenn-helix rooparekhayaanu. kaattalatik domainil niravadhi transposase, recompinase ensaimukalil kaanapedunna hollmark dde (chilappol ddd) amino aasidukal undu. koodaathe, glycine (jii) amino aasidukalaal sambannamaaya oru pradeshavumund.
proteininte multy-domaine swabhaavam kanakkileduthu vividha domaine daattabesukalil traanscriptesukale suuppar faamilikkaayi niravadhi oppukal nalkiyittundu. koodaathe, oro domain palappozhum boxinte pakuthiyil "paii" polulla onniladhikam entrikalaal prathinidheekarikkunnu. chuvanna petti samaanamaayi dive rse (//, muthalaayava) aanu.) palappozhum dna thirichariyunnathinaayi chirakukalulla echhechu roopathilaanu.
upagrooppukal.
tii. sii. 1/mariner suuppar famili saadhaaranayaayi athinte traansposesinte kaattalatik domainukalaal upavibhajanam cheiyunnu. ithu saadhaaranayaayi oru dde (asp-asp-glu) allengil ddd kaattalitik triad upayogikkunnu.
tii. sii. 1.
synorhabditis elegansil" sajeevamaaya oru transposone tii. sii. 1 (dii. dii. 34iii). manushyaril tii. sii. 1 polulla transposonukalum undu, avayellaam nishkriyamaanu. niravadhi malsya enangalum ubhayajeevikalum ulppede mattu thaazhnna kasherukkalil tii. sii. 1 polulla moolakangal kaanapedunnu.
sii. yill. elegans, "ithu 1610 bays-jody dairkhyamulla sreniyaanu. pareekshanangal kaanikkunnath eee moolakam manushyakoshangalil "chaadunnu", athinte transposase maathramaan protein aavashyamaayi varunnath.
eee kudumbatthinte mattoru udaaharanam tii. sii. 3 aanu, ithu "sii" yill kaanapedunna oru traansposon koodiyaanu. elegans ".
naavikan.
manushyar ulppede onniladhikam enangalil marainer marainer moolakangal kaanapedunnu. 1986ll jacobson hartle chernnu drosophilayil aanu marainer traansposon aadyamaayi kandethiyathu. 1993ll eee grouppinte oru vargeekaranam prasidheekarichu, athu praanikalile atharam shrenikale mourishyaana, secropia, mellifera, irittans, kaapittatta upakudumbangal enningane vibhajichu. eee vargeekaranam mattu jeevajalangalilekkum vyaapichittund.
pala jeevajaalangalilum thirascheenamaayi kaimaattam cheyyaanulla asaadhaaranamaaya kazhivinu perukettathaanu eee parivartthana ghadakam. 26 laksham bays jodikal ulkkollunna manushya genome naavikarude 14,000 koppikalundennu kanakkaakkappedunnu. mrugangalkku purathulla aadyathe naavika-moolaka transposonukal trichomonous vajainaalisil kandethi.
manushya navikaneppolulla transposonukale echsmar 1 (secropia), echsmar 2 (irittans) upakudumbangalayi thirichirikkunnu. rund tharangalum nishkriyamaanenkilum, histoon-modify cheiyunna protein dna-binding nalkunnathinaal setmaar jeenil kaanapedunna hsmr 1-nte oru pakarpp thiranjedukkappedunnu. phoosil sequenceukalil ninnu echsmar 2 onniladhikam thavana punarnirmmichittundu.
drosophila mourishyaana" yill moss 1 ("mosaik moolakam" ennathinu) kandethi. hematobia irittans" enna kombu eechayil ninnu himar 1 moolakam verthirichedukkukayum "escherichiya koliyil" oru janithaka upakaranamaayi upayogikkukayum cheyyaam.
mattu kudumbangal.
seratitis rosa" yill kaanapedunna oru kudumbamaanu rossa rossa kudumbam. pogo/phottu 1 (ddxd) eee suuppar faamiliyile mattoru kudumbamaanu, x oru variable dairkhyathe soochippikkunnu. shigella soniyile mobail gadakamaaya gadakamaaya umm eee suuppar faamiliyil pedunnu.
thrayam thammil vyathyastha neelamulla kurachu puthiya kudumbangal koodi report cheyyappettittund.
manushyaril "tiger" ennum ariyappedunna pogo manushyarum yeesttum orupole senpibi jeenilekk valarthiyittundu. tiged 1, tiged 2, tiged 3, tiged 4, tiged 5, tiged 6, tiged 7, jrk, jrkl, pokku, pogs ennivayaanu pogoile mattu manushya valarthumrigangal.

