snx-482

snx-482 ennathu "histerocrates jigas" enna tarantulayil ninnulla oru vishamaan. ithu aarr-type type + (cav2.3) chaanalukalude uyarnna affinity blocker pravartthikkunnu, ennaal uyarnna saandrathayil ithinu mattu type + chaanalukaleyum naa + chaanalukaleyum thadayaan kazhiyum.
srothassukal.
histerocrates jigas" enna chilanthiyude vishathil ninnu snx-482 verthirichedukkunnu.
kramam.
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homology.
snx-482 chilanthi pepttaidukalaaya graammattoxin graammattoxin, hanatoxin ennivaykku thulyamaanu.
lakshyam.
cav2.3 cav2.3, r-tharam) chaanal (sakthamaaya aduppam), l-tharam ca2 + chaanal, p/q tharam ca2 + chaanal, Na + chaanal.
pravartthana reethi.
cav2.3 (a1e, r-type) chaanalukalude selective, volteju-dependent inhibittaraayi eee samyukthathe thudakkathil thiricharinjirunnu. raatt neurohypophiesal naadi terminalukalile durbalamaaya nanomolar saandrathayil thaddesheeya aarr-type type + vaidyuthadhaarakale snx-482 thadayunnu. ennirunnaalum, palatharam elii central neuronukalile 200-500 nm saandrathayil ithu aarr-type ca2 + vaidyuthadhaarakale swaadheenikkunnilla. 200 enm snx-482 upayogichu chikithsichathinushesham aarr-type type + chaanal inhibishane mithamaayi reverse cheyyaan maathrame vaashttinu kazhiyoo. ennirunnaalum, sakthamaaya voltejinte prayogam aarr-type type + chaanalukalude thadayal vipareethamaakkunnu. aarr-type chaanal gettinginte ganyamaaya thadassathil oru punk vahikkunnathin snx-482 nuu eiii1iii domainukalaaya III, IV ennivayumaayi samvadikkendathundu. snx-482 saadhaaranayaayi cav2.3 (eiii1iii, aarr-type) chaanalukalude selective inhibittaraayi kaanappedunnundengilum, ithinu ell-type allengil pii/kyu type type + chaanalukale thadayaanum naa + chaanalukale apoornnamaayi thadayaanum kazhiyumennu aduthide kaanichu.
gaveshanavum chikitsa upayogavum.
traansmittar releasile teflavin-3-jiyude punk vyakthamakkaan snx-482 upayogichittundu. koodaathe, chila gaveshanangal soochippikkunnathu ithu oru neuropathic vedana maathrkayil neuronal prathikaranangale thadayunnathinaal neuropathic vedana chikilsayil dorsal hoonn neuronal vedana kuraykkaan snx-482 upayogikkaan saadhyathayund.

