niyanthranamaan

valarunna yeest sell sykkilile, prathyekichu jii 1 ghattathil, oru transcriptional regulatoraanu vaii 5. athinaal jeenukalude transcriptionil ulppedunna sbfinte oru inhibittaraanu ithu. viai5 sbfl ninnu athu verthirikkal prothsaahippikkunnu, athinte verthirikkal ezz ghattathilekku praveshikkaan aavashyamaaya jeenukalude transcriptionil kalaashikkunnu.
koshachakra purogathiyile punk.
koshachakratthile chekkpoyintukalude arambham, ithu jii 1 avasaanathil ninnu selline ezz ghattathilekku praveshikkaan anuvadikkunnu, koodaathe sellil ninnulla uthejakathodu ellaam allengil onnumillaatha prathikaranamundu. chekkpoyint koshatthe koshatthe allengil ghattathilum ghattathilekku praveshikkaan anuvadikkunnu, koshachakrathilekku praveshikkaan koshatthinte avastha mathiyakanam; udaaharanathinu, koshathinu pattini kidakkunnundengil, allengil poshakakshayam undengil, athu koshachakratthile purogathi nirtthum. ennirunnaalum, staartt chekkpoyint samthrupthamaanenkil koshathinu dna replication aarambhikkaanum koshatthinte valarcha nirthaanum kazhiyum. athinaal jeenukalude transcriptionilekku nayikkunna sambhavangalude cascadil, transcription niyanthranatthil niyanthranamaan ulppedunnu.
david morgan parayunnathanusarichu, ezz. sii. bii-binding factor (ezz. bii. eph), emm. sii. bii-binding factor (emm. bii. eph) enniva yathaakramam ezz. sii. bii. kalumaayum emm. sii. bii. kalumaayum bandhippikkunna transcription gadakangalaanu. athinaal proteinukal prakadippikkunna pradhana jeenukalude mukalilulla promoter pradesangalilaanu ezz. sii. bii. kalum emm. sii. bii. kalum, ithu ithu ninnu ezz ghattathilekkulla parivartthanatthe soochippikkunnu. dna-binding yoonittum (ezz. vii. aii. 4, emm. bii. pii 1) regulatory sub yoonittum (ezz. vii. aii. 6) adangiyirikkunna heterodymerukalaanu transcription gadakangal. ezz. sii. bikalil ezz. vii. aii. 4, ezz. vii. aii. 6 enniva adangiyirikkumbol emm. sii. bii. kall emm. bii. pii 1, ezz. vii. aii 6 enniva adangiyirikkunnu. athinaal, ezz. bii. eph, emm. bii. eph ennivayude sajeevamaakkal jii 1-nirddishta jeenukalude transcriptionil kalashikkum.
ezz. bii. efumaayulla ashayavinimayam.
robertus dii bruyne thudangiyavar nadatthiya oru padanatthil. (2004), ezz. bii. efumaayi bandhippikkunna oru pradhana niyanthrana proteinaan niyanthranamaan ennu gaveshakar kandethi. athinaal, athinaal ezz. sii. bii niyantritha jeenukal avayude transcription adichamarthikkondu dablyu. aii. aii5 vazhi mukalilekku niyanthrikkappedunnu. aadyakaala ghattathilum ghattathil sbf vazhi promotermaarumaayi bandhippikkunna sthirathayulla oru proteinaanithu, transcriptional aaktiveshan kyoo cheiyunnathinumumbu, niyanthranamaan sbfl ninnu verpiriyunnu. athinaal, athinte pravartthanam ezz. bii. eph niyantritha jeenukalude inhibittar ennathinte ninnu enna jaiva nirvachanathe pinthunaykkunnu. koodaathe, maikkal costansoyum mattullavarum nadatthiya mattoru padanavum. (2004) nirnayakamaaya promoterilekku niyanthranamaan neey niyamikkunnathin sbf aavasyamaanennu vishadeekarikkunnu, kaaranam avarude edapedal sthiramaanu.
niyanthranamaan niyanthranam.
david morgan parayunnathanusarichu, oru saiklin-sidike complexes unitaaya viai5/sidikaeeii1, inhibittari hyperphosphorylation vazhi sbfl ninnu athu verthirikkal prothsaahippikkunnu. koodaathe, dii bruyne parayunnathanusarichu, cdc 28 sidike, athu phosphorylationil ulppettirikkunnuvennu vishwasikkappedunnu. cdc 28 cln 1, cln 2, cln 3 ennivayaal sajeevamaakunnu, ithu koshachakratthinte purogathiyude oru pradhana bhagamaanu. sajeevamakkiyaal, aashrayich bandhavum sbfl ninnulla athinte aathyanthika vighadanavum ezz ghattathilekkulla parivartthanatthe sajeevamaakkunnu. mettasovan retinoblastoma protein (arby) pole jii 1-ll niravadhi sthaanangalil ithu phosphorylate cheyyappedunnu, ennaal chila phosphor avashishtangal maathrame jii 1-ll ninnu ezz ghattathilekkulla parivarthanavumaayi bandhappettirikkunnul. koodaathe, niyanthranamaan phosphorylation sbf-ashrita transcriptional aaktiveshan, sell saikkil purogathi ennivayude samayam nirnnayikkunnuvennu dii bruyne vishadeekarikkunnu. udaaharanathinu, oru oru, cln3dii myoottant ennivayil, koshangal ezz ghattathilekku vegathil praveshikkum, kaaranam athu abhavam viai5 sajeevamaakkalinte aavasyakathaye marikadakkunnu. athinaal, oru sii. ell. enn. 3 dii. aii, vii. aii. 5 dii. aii koshangalil, koshachakra purogathiyude samayam sii. ell. enn. 3/sii. dii. keey 1, mattu saiklinukal enniva inhibittari phosphorylation vazhi niyanthrikkappedunnil, ithu cheria kosha valuppathin kaaranamaakunnu. athinaal, athinaal vighadanathinum athu eppol verpeduthanam enna samayathinum viai5/sidikaeeii1 pradhaanamaan. koshachakra sambhavangalude sariyaaya samayam nirnnayikkaan niyanthranamaan nuu maathram kazhiyilla, pakshe ithu parivartthanam aarambikkunnathinulla thudakkathe badhikkunnu.
costanso muthalaayavarude abhipraayathil. (2004), aashrayich sii. dii. keey phosphorilatione aashrayich aashrayich praadeshikavalkkaranam maarumennu vishwasikkappedunnu. transcription gadakangal pole, ithu nucleusilekko nucleusinu purathullathilekko praadeshikavalkkarikkumppedum. sii. dii. keey sajeevamaakukayum athu athu bandhappedukayum cheyyumbol, niyanthranamaan sbfl ninnu verpedukayum athu nucleusil ninnu purathukadakkukayum cheyyum. ennirunnaalum, sii. dii. keey nilavillengilo sajeevamallengilo, niyanthranamaan veendum nucleusilekku praadesikavalkkarikkum. ninnu avasana maittosis ghattathilum ghattathilum ghattathilum nucleusilaanu. maittotik eksitt network sajeevamaakukayum sii. dii. keey pravartthanam kurayukayum cheythaal, niyanthranamaan nucleusilekku praveshikkunnu. koodaathe, viai5 sidike sajeevamaakkumbol, athu athu vighadanathinum nucleusil ninnu athinte anubandha eksittinum kaaranamakum.
niyanthranamaan, viai5 enniva nerppikkal.
kurt schmoller mattullavarum nadatthiya oru patanam. (2015) kaanikkunnath viai5-yude saandrata vardhikkunnathinoppam koshangalude valupavum vardhichukondirikkanu. athinaal, pree-staartt jii 1 athunnathuvare cln 3-nte motham saandrata sthiramaanu. koodaathe, athe kaaryatthil, niyanthranamaan alavu vardhikkukayo kurayukayo cheiyunnilla, ennaal koshangalude valuppam vardhikkunnathinanusaricha motham niyanthranamaan saandrata kurayunnu. athinaal, niyanthranamaan motham saandrata kurayukayum viai5 motham saandrata sthiramaayi thudarukayum cheiyunnathinaal, koshavalarchayiloode niyanthranamaan nerppikkal vyaapanathinte niyanthranathinu kaaranamaakunnu. kaaranamaakunnu ghattangalil, ninnu valuppathe aasrayichulla reethiyil samanvayippikkappedunne gaveshakar kandethi. dotter sell janikkumbol, cheria koshathinu uyarnna saandrathayulla niyanthranamaan undu, ithu koshatthe pree-staartt ghattathilaanu nilanirthunnathu. koshatthinte valippam vardhikkumbol, praadhamika ninnu alavu valia cytosol voliyathil layipikkum, koodaathe sthiramaaya viai5 saandrata ninnu inhibittarinte saandrathayekkaal kooduthalaayirikkum. athinaal, koshatthinte ezz ghattathilekku praveshikkunnathinu samaya maanadandangal enthukondaanennu vishadeekarikkaan niyanthranamaan, viai5 ennivayude saandrathaykku kazhiyum. athinaal, niyanthranamaan inhibittarum inhibittarum ekopanavum kosha valuppathe niyanthrikkunna nirnaayaka proteinukalaanu.
ezz. bii. eph niyantritha jeenukal.
sbf niyantritha jeenukalil ninnu ninnu verpeduthiyaal, athu koshatthe ezz ghattathilekku praveshikkaan anuvadikkunna pradhana jeenukalude transcriptionil kalaashikkunnu. eee jeenukalil adutha ghattatthinte thudakkathinu nirnayakamaaya nirnayakamaaya, ezz saiklin enniva ulppedunnu. viswanath ayyar thudangiyavar parayunnathanusarichu. (2001), ezz. bii. eph niyantritha jeenukal valarunnathinum membran, sell-vaal biosynthesisinum pradhaanamaan. athinaal, aathyanthika koshachakra sambhavangalude oru pradhana niyanthranamaan niyanthranamaan.

