
erby-26

erb-26 oru synthetic eestrajan erbittayude selective agonistum aanu. ithu racemic misrithamaaya erby-79-nte sajeeva enantiomeraanu. erby-79 araa-yekkaal erba-yude 484 madangu selectivity kaanikkumbol, erby-26 ithilum kooduthal selective aayathinal alpam vyathyaasappettirikkunnu, ithu araaumaayi thaarathamyappeduthumbol arbaude trans aaktiveshanaayi 1,000 madangu kooduthal selectivity kaanikkunnu. erbittayude isi 50 moolyam 0.01 enm (estradiolinekkaal 4 madangu durbalamaanu), era 260 enm (estradiolinekkaal 10,000 madangu durbalamaanu) aanu. rund resepterukalilum ithinu virudhamaaya pravartthanamilla. preclinical modalukalil prostettu cancer vikasanam thadayunnathil erb-26 sajeevamaan. erb-26-ll ninnu vyathyasthamayi, thiranjeduttha era agonist yugam-45 preclinical modalukalil testostironumaayi samyojippichu nalkiyappol prostettu cancer vikasanathinu kaaranamaayi, athesamayam testostiron maathram angane cheythilla. eee kandethalukal prostettu grandhiyile era, erbitta ennivayude ethir punk soochippikkunnu. erb-26nte raasaghadana velippeduthiyathaayi thonnunnilla.