
carla green

oru american neurobiologistum chronobiologist aanu carla beth green (jananam 1962). avar neuro sayans vibhaagathile professor texas yooniversitti oof southu vestt medical sentarile neuro sayansil vishishta pandithayumaan. avar biological rhythms (srbr) gaveshana sosaittiyude muun presidentum jappaanile sukuba sarvakalaashaalayile internaashanal instittyoott phoor integrative sleep medisininte upagraha amgavumaanu.
avarude gaveshanathil syrcadian clock tanmatra samvidaanangal upayogichu koshatthinullile thaala prakriyakale athu engane niyanthrikkunnu ennathum ulppedunnu. sasthanikalude syrcadian klokkinte tanmatra samvidaanavum oru jeeviyude shareerashaasthram, biochemistry, perumaattam ennivaykkullil athu engane thaalaathmakathaye madhyasthamaakkunnu ennathum manasilakkuka ennathaanu green laabinte pothuvaaya shradha. avarude labinu nilavil moonnu pradhana projaktukalundu noctornin jeeninte expression niyanthranatthinte lakshyangalum samvidaanangalum thirichariyuka; noctornin nokktu leane elikale upapachayam niyanthrikkunnathinulla samvidaanam thirichariyuka; repressor protein cryptocrom ghadana gadakangal nirvachikkuka, proteente nuclear entriyude niyanthranam syrcadian kaalayalavilekku engane sambhavana cheiyunnu.
sell biology, biochemistry, molecular biology ennivayil aupachaarika pariseelanam nediya green, genomics, proteomics, structural biology, metaboolik padanangal thudangiya patana mekhalakal kooduthal vipuleekarikkaan vishalamaaya vaidagdhyam nalki.
shaasthreeya shradha kendreekarikkunnathinu, avar kooduthal shaasthra samoohathinum sambhavana nalkunnu. 2019 juun <aii. dii. 1>-leeii gorden gaveshana sammelanathil, "model oorganaiseshanukalile klokkukal syrcadian netvarkkukal, physiology, aarogyam", avar samghadippikkunnathu "jii. aarr. sii power avar", stem feeldil sthreekalkkum nyoonapakshangalkkum vaividhyavum ulppeduthalum prolsaahippikkunnathum ellah samudaayangalil ninnumulla ellah amgangaludeyum professional valarchaye prolsaahippikkunnathum charchakalkkum maarganirdeshathinum idam nalkunnathinum roopakalppana cheytha oru paanalaan.
pashchaathalam.
1962 meyy 14 nuu viyamingile cheyenneyil green janichu. aadya varshangalil ammayodoppam viyamingil kurachu samayam chelavazhichathinu sesham, greeninte kudumbam pathivayi maari-aadyam denver, coloradoyilekku; thudarnnu sent pooll, minnesottayilekk; oduvil aval onnaam klaasilaayirikkumbol misouriyile springfieldilake. thekkupadinjaaran misauri stettu yooniversittiyil cherunnathinu munbu kaumaarathiludaneelam avar springfieldil thudarnnu, avide 1984 ll jeevashaasthrathil baachilar birudam nedi. thekkupadinjaaran misauri samsthaanathu thudarnna avar 1986 ll biologyil birudaananthara birudavum nedi. birudaananthara birudam nediya sesham, kansas nagaratthile kansas medical sentar sarvakalashaalayil cherunnathinayi green lephtt springfield, avide phd nedi.dii. biochemistryilum molecular biologyilum simoon kwaakkinoppam pravartthikkunnu. <aii. dii. 1> ll ninnu, kansas medical sentar sarvakalaashaalayile anatomy aandu sell biology vibhaagathil joseph besharsinoppam poost doctoral fello aayirunnu, avide avar "senopus levisinte" rettina photoriseptarukalil syrcadian rithamittiyude molecular mekkanisangalil pravarthichu. 1997-ll avar virgenia sarvakalaashaalayile biology vibhaagathil faakkalttiyil chernnu, "senopus", sasthanikal ennivayile syrcadian thaalangalekkurichulla thante pravartthanam thudarnnu. kooduthal vyakthamaayi paranjaal, kasherukkalil syrcadian oosilettar ulkkollukayum niyanthrikkukayum cheiyunna tanmatra, sellular samvidaanangal avar padichu.
kansas medical sentar sarvakalaashaalayile biruda vidyaarthiniyaayirunpo green aadyamaayi chronobiologic vidheyayaayathu. akkaalat, avar eee vishayathil pravarthichirunnilla, pakshe 1989 ll sell bayolajiyude puthiya chairmaanaayi sarvakalaashaalayilekk recruit cheyyappetta joseph beshaarsinte oru seminar kettu. avar phd poortthiyaakkukayaayirunnu.dii. birudam nediya addeham kansas sittiyil poost doctoral thasthikakalkkayi thirayukayaayirunnu. syrcadian klokkukalude puthiya feeldinekkurichu green kettappol, ithu avale aakarshichu. senopasinte rettinayile endogenous klokkile thante pravarthanathekkurichu besharz samsaarikkukayaayirunnu. akkaalat, oru samvidaanathilum syrcadian klokkukalude tanmatra samvidaanathekkurichu onnum ariyillaayirunnu. oru biochemistaayum molecular biologistaayum pariseelanam nediya avar, atharamoru aakarshakamaaya jaiva vairudhyathil pravartthikkaan thante kazhivukal upayogikkaan eee mekhala anuyojyamaaya sthalamaakumennu karuthi. besharz avale thante labil oru poost doctoral vidyaarthiyaayi niyamichu, annumuthal aval syrcadian klokkukal padikkunnu.
texas yooniversitti oof southu vestt medical sentarile neuro sayans departmentinte ippozhathe chairmaanaaya joseph takahashi green vivaham kazhichu.
currier.
gaveshanam.
nilavil texas yooniversitti oof southu vestt medical sentarile neuro sayans vibhaagathile pradhana anweshakanaanu green. vivarthana, poost-transcription prakriyakal modulate cheiyunna regulatory mekkanisangalil prathyeka thaalpparyathode sasthanikalile syrcadian thaalangalude tanmatra samvidaanathekkurichu avarude laab padikkunnu. noctorninte syrcadian pravartthanam, mettabolisatthinte syrcadian niyanthranam, cryptocromte pradhana gadakangalude syrcadian ghadanayum pravartthanavum enniva manasilakkunnathil green laab nilavil shradha kendreekarikkunnu.
raathriyil.
green laabile oru pradhana shradha noctornin jeane encode cheytha oru proteinil aanu, athinte uyarnna thalatthilulla rathrikaala padaprayogatthinu perittirikkunnu. marnah poliya vaalukalude apachayathil ulppedunnuvennu karuthappedunna oru dedenylase aanu noctornin, ithu poost-transcriptional sthirathayilum syrcadian jeane expression niyanthrikkunnathilum oru punk vahikkunnuvennu soochippikkunnu, ithu mettabolisathinum aathyanthikamayi atijeevanathinum ettavum gunam cheiyunnu.
1996-ll, senopus levisinte rettina photoriseptarukalil "noctornin" ("noock") kandethi, avide "noock" marnah oru otappetta "senopus" kannil prakasham/irundathum sthiravumaaya avasthakalil thaalaparamaaya aavishkaaram pradharshippichu. senopus rettinayile thaalaparamaaya jeenukalkkaayi uyarnna strincy deferential display screen upayogichaanu avar eee jeenine verthirichathu. 2001-ll, uyarnna digri coding sequence samaanathayulla elikal polulla mattu speesheesukalil pacha "noock" homologukal kandethi. eee padanangal elikalilekku vyaapippichathinusesham, mouse "noctornin" marna thaalaathmakamaanennum syrcadian clock adangiya pala tissuekalilum prakadippikkappedunnum avar theliyichittundu. rasakaramennu parayatte, maasttar clock jeane expression niyanthrikkunnathil "noock" nerittu ulppedunnillengilum, oosilettar outtputtu pravarthanangalkku ithu aavasyamaanennu greens group theliyichittundu, athuvazhi syrcadian physiologyil sambhavana cheiyunnu.
karal, kudalukal thudangiya upapachayam nirnayakamaakkunna koshangalil, "noctornin" ("noock") enna thaalaathmakamaaya aavishkaaram shareerathiludaneelam kaanapedunnu. 2011-ll, pacha, doris, mattullava ennivaykku vyathyasthamaaya "noock" phenotypeukal kaanikkan kazhinju, ithu austiyojenisis, lipogenesis, adipogenesis ennivayil eee jeeninte pankaalitthatthe soochippikkunnu.
avarude laabinte nilavile gaveshanam noctorninte syrcadian-prasakthamaaya mrna lakshyangal thirichariyunnathilum avayude aavishkaaram engane niyanthrikkunnuvennu manasilaakkunnathilum shradha kendreekarikkunnu.
syrcadian thaalangalude poost-transcription niyanthranam.
2011-ll, marnah eksprashante sakthamaaya syrcadian thaalangal srishtikkunnathinu transcriptional, poost-transcriptional prakriyakal aavasyamaanennu greens laab nigamanam cheythu, ennaal syrcadian poost-transcriptional samvidaanangalekkurichulla daaranakal transcriptional thalatthil clock reguleshanekkurichulla daaranayekkaal valare pinnilaanu. poost transcription niyantritha jeenukal valia thothil kandethunnathinulla nannayi vikasippicha reethikalude abhaavamaan ithinu kaaranamenn kandethi. atharam reethikalude vikasanam poost-transcription niyanthranatthilulla niravadhi jeenukaludeyum samvidaanangaludeyum kandethalilekku nayikkumennu rachayithakkal vishwasikkunnu.
sasthanikalude syrcadian klokkinte poost-transcription niyanthranathekkurichu sameepakaala sambhavavikasangalil greeninte kandethalukal udharikkappedunnu. greeninte gaveshanathil ninnu prachodanam ulkkond 2016 leeii sameepakaala kandethalukal chronomedicine, urakka vaikalyangal ennivayumaayi bandhappett manushya syrcadian sisttangalude poost-transcription niyanthranathinu sambhavana cheiyunnu.
cryptocrom.
sasyangalilum mrugangalilum kaanapedunna neela velicham risapttar proteinukalaaya cryptochromukal ennariyappedunna oru klaas proteinukalil greens laab valareyadhikam shradha kendreekarichu. praanikalilum sasthanikalilum syrcadian klokkinte sariyaaya pravartthanatthinum sasyangalude sariyaaya vikasanathinum cryptocrom proteinukal athyaavasyamaanu. cryptoproteinukal sasyangaludeyum praanikaludeyum sasthanikaludeyum syrcadian klokkukale vyathyastha reethikalil niyanthrikkunnu. eee avashya transcriptional adichamarthalukalude rahasyangal kandethunnathinayi green oru ubhayajeeviyaaya aafrikkan nakhamulla thavala (allengil senopus lavis), sasthanikalaaya krai 1, krai 2 ennivayumaayi vipulamaayi pravarthichittundu.
2003ll clock, bml1 thudangiya mattu syrcadian clock jeenukalude sajeevamaakkal adichamarthunnathil cryptocrom vahikkunna punk avalum sahapravarthakarum anweshichappol cryptocromukalekkuleku greeninte gaveshanam aarambhichu. cryptocrom sii-terminal domaine illaathaakkunnathu proteinukalkku eee jeenukalude sajeevamaakkal adichamarthaan kazhiyillennu avar velippeduthi. eee phalam soochippikkunnathu sii-terminal clock/bml 1 adichamarthunnathinulla domainallennum ennaal nuclear localisation maathram athyaavashyamaanennum soochippikkunnu.
cryptocrom oru pradhana punk vahikkunna suprachiyaasmaattik nucleus peripheral syrcadian oosilettarukalum thammilulla bandhavum green padichu. udaaharanathinu, "krai1" enna niyanthrana mekhalayil glucocorticoid hormoninullah oru prathikarana mekhala adangiyirikkunnu, eee hormon inputtinu "krai1" enna transcription sajeevamakkaan kazhiyum. "krai1/krai2" nall elikalil, 24 manikkoor edavelakalil pathivayi bhakshanam kazhikkunnath niravadhi traanskripttukalude, prathyekichu metabolisavumaayi bandhappettavayude syrcadian expressione preripikkum. central oosilettarinte saadhaarana syrcadian feedback looppukale peripheral oosilettarukalkku engane marikadakkaan kazhiyumennu ithu kaanikkunnu.
aduthide, 2018-ll, klokkumaayum bml1-maayi nerittulla edapedaliloode niyanthranathinu madhyasthatha vahikkunna oru puthiya qoo-factor kandethunnathinu green sambhavana cheythu. eee patanam cryptochromukalude ghadanayum clock regulatory samvidaanangalum vyathyaasappedunna parinaama samvidaanathinu oru maathruka nalkunnu.

