
maannik prathikaranam

jaiva rasathanthrathil, carbonyl () functional groupinu aduthulla oru acidic protoninte amino alchylation ulppedunna moonnu gadakangalulla jaiva prathikaranamaanu maannik prathikaranam, formaldehyde (), primery allengil secondary amine () allengil amonia () enniva upayogichu. maannikk bays ennum ariyappedunna β-amino-carbonyl samyukthamaanu anthima uthppannam. aaldimainukalum α-methylene carbonilukalum thammilulla prathikaranangalum maannik prathikaranangalayi kanakkaakkappedunnu, kaaranam eee aiminukal amainukalkkum aldehydeukalkkum idayil roopappedunnu. 
kaal maannichinte peraanu eee prathikaranatthinu nalkiyirikkunnath.
oru carbonyl groupilekku oru amine nucleophilic cherkkunnathiloodeyum thudarnnu shif adithattilekku nirjjaleekaranam nadathunnathiloodeyum maannik prathikaranam aarambikkunnu. acidic alfa-prottoon adangiya carbonyl samyukthathil ninnu roopappedunna enolumaayi electrophilic kootticherkkalile randaam ghattathil prathipravartthikkunna oru electrophylaanu shif bays. mannik prathikaranam oru ghaneebhavana prathikaranamaanu.
maannik prathikaranatthil, praadhamika allengil dvitheeya aminukal allengil amonia formaldehydeumaayi prathipravartthichu oru shif bays roopappeduthunnu. thritheeya aminukalkk oru enn-echu prottoon illaathathinaal avaa prathikarikkunnilla. carbonyl samyukthangal, naitrail, asattileenukal, aliphatic naitro samyukthangal, α-alkail-pyridinukal allengil immins enniva ulppedunna α-ch-acidic samyukthangalumaayi (nucleophylukal) shif bays prathikarikkum. sajeevamaaya phenyl grouppukalum electron sambushtamaaya hetarosaikkilukalaaya furan, pyrol, theophene ennivayum upayogikkaan kazhiyum. indoll oru prathyekamaayi sajeevamaaya substrate; prathikaranam gramine derivateevukal nalkunnu.
mannik prathikaranatthil oru mixed-aldol prathikaranam, madyathinte nirjjaleekaranam, oru amine (maikkal prathikaranam) ennivayude samyojitha kootticherkkal enniva ulppedunnu, ellaam "oru-paathram" ll sambhavikkunnu. eratta maannik prathikaranangalum sambhavikkam.
prathikarana samvidaanam.
amainil ninnum formaldehydil ninnum oru iminium ayoon roopappedunnathodeyaanu maannik prathikaranatthinte samvidaanam aarambhikkunnath.
carbonyl functional groupulla samyuktham (eee saahacharyathil oru kettoon) enol roopathilekku tatomerise cheyyum, athinusesham athu iminium ionine akramikkunnu.
methyl kettonukalil, anolysation maannikk kootticherkkalum randuthavana sambhavikkam, thudarnnu β-amino enoon derivateevukal labhikkunnathin β-elemination.
asamamaya maannik prathikaranangal.
maannik prathikaranangalkk ("kall")-prolin kairal kaattalist upayogikkaam.
propionaldehyde ethyl glyooxilettil ninnu uruthirinja oru aiminum thammilaan prathikaranam nadakkunnathu. proline kaattalist parishkkarikkunnathiloode aanti-maanikk aadktukal nedaanum kazhiyum.
aaplikkeshanukal.
jaiva rasathanthrathinte pala mekhalakalilum maannik prathikaranam upayogikkunnu, udaaharanangalil iva ulppedunnu