
3-dehydroquinate synthase

3-dehydroquinate synthase (iii. sii. <aii. dii. 1>) enna ensime raasapravarthanathe uthejippikkunnu.
prathikaranatthe uthejippikkaan protein naad + upayogikkunnu. sugandha amino aasidukalude jaivasamshleshanathil ulppedunna shikkimett paathayude bhagamaanu eee prathikaranam.
phosphettukalil pravartthikkunna kaarban-ooksijan lices ennu prathyekam paranjaal, 3-dehydroquinate synthase lices kudumbatthil pedunnu. eee ensime fenylalanine, tyrosine, tryptophan biosynthesis ennivayil pankedukkunnu. ithu cobalt (qoo2 +) enna oru cofactor upayogikkunnu.
pashchaathalam.
oro ghattavum oru ensime uthejippikkunna ezhu gattangal chernnathaanu shikkimett paatha. nammude bhakshanakramathinu athyanthaapekshithamaaya sugandha amino aasidukalude mungaamikal uthppaadippikkunnathin utharavaadiyaanu shikimettu paatha, kaaranam avaye nammude shareerathil samanvayippikkaan kazhiyilla. sasyangal, bakteeriyakal, microbial yookkariyottukal ennivaykku maathrame sugandha amino aasidukal utppaadippikkaan kazhiyoo. eee paatha aathyanthikamayi phosphoenolpyruvettine 4-erythros phosphatineyum sugandha amino aasidukalude munnodiyaaya korismettaayi parivartthanam cheiyunnu. eee paathayude randaam ghattathil prathikaranatthe uthejippikkunna ensaimaanu 3-dehydroquinate synthase. prathikaranatthinte eee randaam ghattam 3-deoxy-dii-arabino-heptulosonettu 7-phosphettil ninnu oru phosphettine illaathaakkunnu, ithu 3-dehydroquinatine kaaranamaakunnu. 3-dehydroquinate synthase oru monomeric ensaimaanu, ithinu 39,000 tanmatra bhaaramund. 3-dehydroquinate synthase ajaiva phoosphett upayogichu sajeevamaakkunnu, pravarthanatthinu naad + aavasyamaanu, ennirunnaalum oru ensime catalise cheyyumbol motham prathikaranam neutral aanu.
pravartthanam.
alcohol ooksideshan, phoosphett β-elemination, carbonyl reduction, ring ooppaning, intramolecular aldol condensation enniva ulppedunna sankeernamaaya multy-steppu samvidaanam 3-dehydroquinate synthase upayogikkunnu.
3-deoxy-dii-arabino-heptulosonettu 7-phoosphett 3-dehydroquinateayi parivartthanam cheiyunnathinu dehydroquinate sintesinu naad + umm oru cobalt cofactor aavasyamaanu. cheria valippavumayi thaarathamyappeduthumbol sankeernamaaya pravartthanam kaaranam dehydroquinate sintesinu prathyeka thaalpparyamund. mikka bakteeriyakalilum eee ensaiminu oru pravartthanam maathrameyulloo. ennirunnaalum, fangasukalilum prottistukalilum, shikkimett paathayude rund, moonnu, naalu, anchu, aarr gattangal ulkkollunna pentafangshanal aarom complexinte bhaagamaanith. 3-dehydroquinate dehydratesinoppam 3-dehydroquinate sindesaanu eee samuchayathinte kaathal. 
aaplikkeshanukal.
3-dehydroquinate synthase shikkimett paathayile randaam ghattathe uthejippikkunnu, ithu bacteria, sasyangal, fungus ennivayil sugandha amino aasidukalude ulppaadanathinu athyaavasyamaanu, pakshe sasthanikalalla. ithu puthiya antimicrobial ejantukal, aanti-paaraasitik ejantukal, kalanaashinikal ennivaykku anuyojyamaaya lakshyamaakkunnu. shikkimett paathayile mattu ensimeukal ithinakam lakshyamidukayum kalanashinikalaayi upayogikkukayum cheythittundu. monsaanto nirmmicha oru saadhaarana kalanashiniyaaya roundappu, shikkimett paathayile mattoru ensaimine thadayunnathiloode pravartthikkunnu. sasyanaashinikalkk anuyojyamaaya oru thiranjeduppaanu shikkimett paatha, kaaranam eee paatha mrugangalilo aalukalilo nilavillillaathathinaal aalukale nerittu baadikkilla. shikkimett paathayude oru ghattam thadayaan raundu upp glyphosate enna ensime inhibittar upayogikkunnu. glyphosate 5-anolpirevilshicmite-3-phoosphett sinthesine (eiii. pii. ezz. pii synthase) thadayunnu, ithu aathyanthikamayi sugandha amino aasidukalude ulppaadanathe thadayunnu, koodaathe sugandha amino aasidukalillathe sasyangalkk athijeevikkaan kazhiyilla. ennirunnaalum, roundappu vazhi thadayappedaatha eiii. pii. ezz. pii sinthesinte oru bacteria roopam monsaanto vikasippichu. agrobacterium upayogichu monsaanto eee jeane sasyangalil avatharippichu, athinte phalam roundappu prathirodhikkunna oru chediyaayirunnu. ithinartham bacteria jeane illaatha ellah sasyangalum marikkukayum ithu valare uyarnna alavilulla kalla niyanthranathilekku nayikkukayum cheyyum ennaanu.
namakaranam.
eee ensime klaasinte chittayaya peru 3-deoxy-"arabino"-heptt-2-yulosonettu-7-phoosphett phoosphett-lies (cyclising; 3-dehydroquinate-forming) ennaanu. 5-dehydroquinate synthase, 5-dehydroquinic assid synthase, dehydroquinate synthase, 3-dehydroquinate synthase, 3-deoxy-arabino-heptulosonettu-7-phoosphett phoosphett-leys, (cyclising), 3-deoxy-arabino-heptulonettu-7-phoosphett phoosphett-leys (cyclising) ennivayaanu saadhaarana upayogathilulla mattu perukal.