
antimycin eiii

streptomises" bacteria ulppaadippikkunna oru dvitheeya metabolaittum aantimaisinukal ennariyappedunna anubandha samyukthangalude oru koottatthile amgavumaanu antimycin eiii (kooduthal krithyamaayi antimycin eiii1bii). yuu. eiii. yude sekshan 302 ll nirvachichirikkunnathupo, amerikkayil antimycin eiii valare apakadakaramaaya oru padaarthamaayi tharamthirickunnu.ezz. emarjansi planning aandu community raitt-tuu-noow act (42 yuu.ezz.sii. 11002), ithu ganyamaaya alavil uthppaadippikkunna, sambharikkunna allengil upayogikkunna soukaryangalude karsanamaaya reporting aavasyakathakalkku vidheyamaan.
upayogikkuka.
fisheries maanejmentil upayogikkunna raasa malsyanaashiniyaaya (malsyavisham) fintrolile sajeeva gadakamaanu antimycin eiii.
1945ll aadyamaayi kandethiya antimycin eiii, 1960ll malsya vishapadaarthamaayi upayogikkunnathinaayi rajisttar cheyyappettu. nilavil rajisttar cheytha eaka ulppannamaaya fintroll ® aanu antimycin eiii adangiyirikkunnathu, jalavishabadhayum athu upayogikkunnathinu uyarnna prathyeka parisheelanatthinte aavasyakathayum kaaranam niyantritha upayoga keedanaashiniyaayi tharamthirickunnu. 1993-ll, niravadhi toxicology padanangal yunaittad stetts paristhithi samrakshana agencic athinte vishaamsham nalki.
vamshanaashabheeshani neridunna oru pradeshathe aakramanathmaka enangale illaathaakkaan federal, samsthaana sarkkaarukalaan praadhamikamaayi fintroll upayogikkunnathu. oru bilyanil 25 bhaagangalude saandrata kaivarikkunnathinu antimycin eiii drope thirichullava cherkkunnu. bottukalkkum gathaagathathinum prapyamaaya pradeshathu eee drip steshanukal saadhaaranayaayi mukalilekku upayogikkunnu. aazhathilulla jalashayangalil, jalanirappinte neelam neettiya sushiramulla kuzhaliloode antimycin eiii chitharikkaan oru pump samvidaanam upayogikkunnu.
akwakalcharil, cheruthum kooduthal sensitiivu aaya enangale thiranjedutthu kollunnathiloode catfish uthppaadanam vardhippikkunnathinu antimycin eiii oru ejantaayi upayogikkunnu. 25 ppb yill antimycin eiii cherkkumbol athu oru samboornna killu nalkunnu. ennirunnaalum, 10 ppb enna nilayil, vaanijyakrishiyude vilavu kurachekkaavunna cherutho kooduthalo sensitiivu speesheesukale kollan thiranjeduttha kola ejantaayi antimycin eiii upayogikkunnu.
antimycin eiii adangiya uthppannangal apakadasaadhyatha laghookarana nadapadikramangal paalichaal avaa rajisttar cheyyaan kazhiyum.
innuvare manushya vaidyathil oru upayogavum undaayittillengilum oru chemotherapic enna nilayil athinte saadhyatha paryavekshanam cheyyappettu.
pravartthana samvidaanam.
sellular shwasanathinte, prathyekichu auxidative phosphorylationte oru inhibittaraanu antimycin eiii. antimycin eiii cytochrome sii reductasinte kyuai saittumaayi bandhippikkukayum kyuai saittile ubiquinol ubiquinonilekku ooksideshan thadayukayum athuvazhi ensaiminte kyu-saikkil teenn oovarine thadassappeduthukayum cheiyunnu. ithu muzhuvan electron gathagatha shringalaykkum thadassamundaakkum. ithumoolam eiii. tii. pii. yude uthppaadanam saadhyamalla. auxidative phosphorylationte electron transport shringalayile oru kendra ensaimaanu cytochrome sii reductase.
eee prathikaranatthinte thadassam mitocondriyayude aantharika stharathiludaneelam prottoon gradiantinte roopeekaranathe thadassappeduthunnu. prottoon gradiantinte abhaavathil protonukalkku eiii. tii. pii synthase complexiloode ozhukaan kazhiyaathathinal eiii. tii. piyude uthppaadanam pinneedu thadassappedunnu. eee nirodhanam visha free radical soopparksaidinte roopeekaranathinum kaaranamaakunnu. aantimaisinte saannidhyathil superxide ulppaadana nirakkinte ooksijan nilaye aashrayikkunnath hyperbolic aanu. mitocondrial shwasana nirodhanatthinte pashchaathalatthil samskaricha koshangalil, superxide ulppaadanathinte nirakk athine vrithiyaakkunnathinulla sellular samvidaanangale kaviyunnu, ithu koshatthe amithamaakkukayum koshangalude maranathilekku nayikkukayum cheiyunnu.
nirddishta ferredoxin kwinon reductase paathayiloode photosynthetic sistangalkkullile chaakrika electron ozhukkine ithu thadayunnuvennum kandethiyittundu.
electron transport cheyin thadayaan sionide pravartthikkunnundena, antimycin eiii, sionide enniva vyathyastha samvidaanangalil pravartthikkunnu. ayal proteinil irumbu saadhaaranayaayi bandhippikkunna oru saittine sionide bandhippikkunnu, ithu ooksijane bandhippikkunnathil ninnu thadayunnu. ithu koshangalude shwasanathe poornnamaayum thadayunnu, ithu koshangalude maranathilekku nayikkunnu. electron transport cheyinile oru prathyeka proteinumaayi antimycin eiii bandhippikkunnathinaal, yubikvinolile sookshumamaaya speeshees prathyeka vyathyaasangal kaaranam athinte vishaamsham valare speesheesukale ashrayichirikkum. athukondaanu vaanijyakrishiyil fintroline oru selective killing ejantu aayi upayogikkunnathu.
fungus valarunna attain urumbukal avayude fungus valarchayil symbiotic "streptomises" bacteria ulppaadippikkunna aantimaisinukal upayogikkunnathaayi theliyikkappettittund, ithu kaltiwar ithara (athaayath.iii. rogakariyaaya) fungus. eee symbiotic streptomises bakteeriyakalekkurichu padikkunna oru gaveshana samgham aduthide aantimaisinukalkkayulla biosynthetic jeane klasttarine thiricharinju, ithu 60 varsham munbu samyukthangal thiricharinjittunde anjjaathamaayirunnu. oru hibrid polycatide synthase (pii. keey. ezz)/noonn-ribosomal pepttaid synthase (enn. aarr. pii. ezz) upayogichaanu aantimaisinukal samanvayippikkunnathu.
vishaamsham.
marakamaaya dosukal.
malsyangalilum ubhayajeevikalilum marakamaaya alavu 
sasthanikalile marakamaaya alavu 
manushyarude sanbarkkavum pradhamashushrooshayum.
samskaricha vellathinte sanbarkkam
vittumaaraathathum, upa-maarakavumaya manushya sanbarkkathinte phalangal murine (= elikalkku bandhapetta) toxicology padanangalil ninnu kanakkaakkukayum bahishkarikkukayum cheythittundu. iii. pii. eiii risk asasment protocolukal upayogichaanu saahithyathile kanakkukal nirnnayikkappettath. eee nilakal nirnnayikkaan lakshyamitulla padanangal "prathikoola phalatthinte alavu nireekshikkaatha" elikalil saandrata kandethi."avide ninnu, oraalude jeevithakalam muzhuvan nireekshikkaavunna prathyaaghaathangalonnumil divasena kazhikkaan kazhiyunna padaarthatthinte uyarnna paridhiyaya reference doses (rfd) nirnnayikkunnathinulla reethikal epa vivarikkunnu. rfd prathidinam 1.7 microgram/kilogram aayi nirnnayichu. ekadesham 70 kilogram bharamullah oru muthirnnayaalkk 60 ppb nirakkil 2 littar shudheekaricha vellam surakshithamaayi upayogikkaan kazhiyum.
padaartham aakasmikamaayi kazhikkunnath moolam visha efakttukal undakam. 40 graamil thaazhe antimycin eiii ullathinaal athu vyakthiyude aarogyathinu gurutharamaaya prathikoola phalangal undaakkumenn mrugangalude toxicology padanangal soochippikkunnu.
rogalakshanangal laghookarikkunnathilum shwaasakosha sambandhamaaya budhimuttukal, pulmonary edema, apasmaram, shock enniva nireekshikkunnathilum chikitsa shradha kendreekarikkunnu. kendra naadeevyoohatthile vishaadathinu kazhikkunnathinu sheshamulla emessis shupaarsha cheiyunnilla. sajeevamaaya curry 240 millie vellamayi 30 gram curry upayogichu nalkaam. vyavasthaapithamaaya lakshanangalum adayaalangalum vikasikkunnathin rogiye nireekshikkanam. shwasichathinushesham rogiye shudhavaayuvilekku maattukayum brongospasm, shwasikkaan budhimuttu, shwasana budhimuttu enniva nireekshikkukayum venam. aavashyamenkil, rogikk ooksijan nalkukayum trackle intubation vazhi oru shwaasanaalam surakshithamaakkukayum cheyyuka. shwasikkunna beetaa 2-adrenergic agonistum kadinamaaya brongospasavum upayogichu brongospasmine chikilsikkunnathu systemic corticosteroidukal upayogichu chikilsikkaam.

