
transmembrane protein 53

manushyaril chromosome 1-ll encode cheythirikkunna oru proteinaan transmembron protein 53, allengil tmm 53. ithinu paaralogukalonnumillengum yookkaariyottukalil udaneelam niravadhi oorthologukal undaakumenn pravachikkappedunnu.
savisheshathakalum ghadanayum.
dvitheeya ghadana.
tmem 53-nte dvitheeya ghadanayil alfa helisukaludeyum beetta sheettukaludeyum marimari jody adangiyirikkumennu pravachikkappedunnu.
badal splissing.
tmem 53 nuu 3 exonukalundu. 26 badal exonukal upayogichu panthrand badal splies roopangal thiricharinjittundu. oro isophomine vivarthanaananthara mattangal pravachikkunnath thaazhepparayunna pattikayil ulppedunnu.
pravartthanam.
tmem 53-nte pravartthanam poornnamaayum manassilakkiyitla. ekadesham 240 amino aasidukal neelamulla "duf829" enna anjjaathamaaya pravartthanatthinte oru domaine ithil adangiyirikkunnu. eee domaine tmem 53, athinte oorthologukal enniva ozhikeyulla proteinukalil kandethiyitla.
aavishkaaram.
manushyarudeyum elikaludeyum profileukaleyum manushya tissue jio profilineyum adisthaanamaakki, saadhaarana, cancer tissuekalil kuranja alavil tmem53 sarvavyaapiyaayi prakadippikkunnathaayi kaanapedunnu.
kooduthal nirddishta avishkaara paattenukalum nireekshikkappettundu
homology.
transmembrane protein 53 nuu paaralogukalilla. ennirunnaalum, praimettukal muthal ameeba vare yookkaariyottukaliludam vyaapichukidakkunna oorthologukal ithinu undu. thaazhepparayunna pattika spodanaathmakavum nagnavumaaya thirayalukal upayogichu kandethiya oorthologukalude oru thiranjeduppu avatharippikkunnu. ithu oru samagramaya pattikayalla, marichu oorthologukal kaanapedunna speesheesukalude vaividhyam pradarshippikkaan uddeshichulla oru cheria thiranjeduppaanu.
mukalil paranjava ulppede 38 oorthologukalude klasttal multiple sequence alainmentukale adisthaanamaakki, eee protein upayogichu 11 amino aasidukal ellah speesheesukalilum poornnamaayum samrakshikkappedunnu.
vivarthanaananthara parishkkaranam pravachichu.
maihits motif scan polulla bioinformatic vishakalana upakaranangalum vividha upakaranangalum upayogichu onniladhikam sequence alainmentukalumaayi thaarathamyappeduthukayum, vivarthanaananthara parishkkaranatthinte saadhyathayulla sittukal valare samrakshikkukayum cheythu. thaazhepparayunnava pravachicha parishkkarana saittukalude samagramaya pattikayalla; athil uyarnna parirakshitha amino aasidukal upayogikkunnava maathram ulppedunnu.
tyrosine phosphorylation sittinulla tyrosine aaya tii216 umm pravachicha sii. keey. 2 phosphorylation sittinulla serin aaya ezz217 umm proteente parinaama charithrathiludaneelam poornnamaayum samrakshikkappedunnu. proteente pravarthanatthinu eee sittukal yadhaarthavum pradhaanavumaanennathinu ithu uyarnna saadhyatha soochippikkunnu.

