
krisanlisumab

pii-selectin enna marunnine bandhippikkunna monoclonal antibody marunnaan adakviyo enna brand naamatthil vilkkunna chrysonlisumab. sickle sell anaemiya ulla 16 vious athil kooduthalumulla aalukalil vasso-clusive prathisandhiyude aavruthi kuraykkaan upayogikkunna marunnaanith. ithu oru sirayilekku kuthivaykkalaanu cheiyunnathu.
sandhi vedana, ookkaanam, naduvedana, panii, vayaruvedana ennivayaanu ettavum saadhaaranamaaya paarshwafalangal.
2019 novemberil amerikkayil vaidyashaasthraparamaaya upayogathinaayi chrysonlisumab amgeekarichu.ezz. phudu aandu drugg administration (eph. dii. eiii) ithine phastt-inn-klaas marunnayi kanakkakkunnu.
medical upayogangal.
16 vious athil kooduthalumulla sickle sell roga rogikalil aavarthichulla vasso occlusive prathisandhikal thadayunnathinu krisanlisumab soochippikkunnu. hydroxyuria/hydroxy carbamide (echu. yuu/echu. sii)-ykkulla aadu oonn therapyayo echu. yuu/echu. sii anuchithamo aparyaapthamo aaya rogikalil monotherapyayo ithu nalkaam.
ariwal koshangalude rakthachamkramanam thadassappedumbol undaakunna ariwal koshangalude rogathinte saadhaaranavum vedanaajanakavumaaya sankeernathayaanu vasso-culsitive prathisandhi (chuvanna koshangal saadhaaranayaayi vrithaakruthiyilullathum vazhakkamullathumaan, ennaal chilappol ariwal kosha anaemiya ulla oru vyakthiyile pala chuvanna koshangalum haemoglobin polymerisation kaaranam karkkasavum chandrakala aakum).
pathophysiology.
sajeevamaaya platelettukaludeyum vascular endothelial koshangaludeyum uparithalathil pii-selectin thanmathrakal kaanapedunnu, avaa ariwal koshamaaya vasso-occlusive prathisandhikalumayi bandhappettirikkunnu.
charithram.
vasso-clusive prathisandhiyude charithramulla sickle sell rogangalulla 132 rogikalude oru klinikkal trialil (trial 1/nct01895361) ninnulla thelivukalude adisthaanathil us phudu aandu drugg administration (fda) krisenlisumabinu amgeekaaram nalki. america, brazeel, jamaikka ennividangalile 60 sthalangalilaanu pareekshanam nadannathu.
krisanlisumab munganana avalokanam, breakthroo therapy padavi, anatha marunnu padavi ennivaykkulla apeksha fda anuvadichu. eph. dii. eiii. novartisinu adakviyoyude amgeekaaram nalki.
europian medisins ejansiyude human medisins kammitti (chmp) sickle sell rogamulla rogikalil vasso-clusive prathisandhikal thadayunnathinulla marunnaaya adakviyo (krisanlisumab) pinvalikkaan shupaarsha cheythu, kaaranam apakadasaadhyathakalekkaal mathiyaya gunangalude abhavam. aduthide nadanna moonnaam ghatta patanam, oru placeboyumaayi thaarathamyappeduthumbol aarogya samrakshana sandarshanangalo chikitsayo aavasyamulla vedanaajanakamaaya prathisandhikalude ennam adakvio phalapradamaayi kurachillennum gurutharamaaya paarshwafalangalude uyarnna nirakk ithu prakadippichuvennum kaanikkunnu.

