
dariya hasuda

aadyathe echuaivi integrase strand transfer inhibittarukal (instis) kandethunnathinum fda amgeekaaram nedunnathinulla aadyathe echuaivi integrase inhibittar, icentress (raltegravir) vikasippikkunnathinum peruketta oru biochemistaanu daria jeey hasooda. eee inhibittarukalude pravartthana samvidaanavum vairasinu avayodu prathirodham valarthiyedukkaanulla vazhikalum avarude laab nirnnayichu. hasooda vipulamaaya gaveshanam nadathukayum elbasweer, grasopreveer ennivayulppede heppattaitis sii vairasinaayulla (echsivi) aantivairalukalude vikasanathinu neethrthwam nalkukayum cheythu. avar nilavil merkkinte pakarchavyaadhikal kandethunnathinulla vais presidentaayum avarude emrl kembridge exploratory sayans sentarinte cheef scientific offeesaraayum sevanamanushtikkunnu.
aadyakaala jeevithavum vidyaabhyaasavum.
nyoojezhsiyile hillsburo tounshippilaanu hasooda valarnnathu. avalude pithaav oru enchineeyaraayirunnu, avalude amma jansen farmaceuticayude (ippol jonson & jonsante bhagamaanu) regulatory-compliance divisionil jolie cheythu. 1977ll hillsburo haiskoolil saloottettoriyanaayi birudam nedi. thudakkathil jorstaun sarvakalashaalayil premedical birudam nediya avar oru laabile part time jolikkidayil gaveshanavumaayi pranayathilaakukayum mayakkumarunnu kandethalilekku pookaan theerumaanikkukayum cheythu. avalkk bii labhichu.ezz. ratjezhs sarvakalashaalayil ninnu phd, stooni brookile stettu yooniversitti oof newyorkkil ninnu biochemistryil phd, avide avar cheng-wenn vuyil pariseelanam nedi. thudarnnu avar molecular janithakashaasthra vibhaagathil smith, kline, franch ennividangalil poost doctoral research fellowship cheythu.
currier gaveshanavum.
1989 ll merkle chernna hasuda avide aantivairal research groupile muthirnna research biochemistaayi aarambhichu. thudakkathil influvensayekkurichu pravartthikkaan avale niyogichirunnuvenkil echuaivi gaveshanathilekku marran avar aavasyappettu. deerghakaalamaayi pravartthikkunna aanti retroviralukalude vikasanam ulppedunna merkkinte echuaivi gaveshanathinu avar melnottam vahikkunnath thudarunnu. heppattaitis sii vairasinaayulla (echsivi) aantivairal chikilsakal vikasippikkunnathilum avar pradhana punk vahichittundu, ithu elbasweer, grasopreveer ennivayulppede heppattaitis sii vairasinaayulla (echsivi) aantivairalukalude vikasanathinu neethrthwam nalki. koodaathe, merck research laborattari cambridge exploratory sayans sentarinte cheef scientific officer enna nilayil avar manushya microbiome prathirodhasheshiyum thammilulla edapedalukalekkurichulla gaveshanathinu melnottam vahikkunnu. merkkinte aagola maanava aarogya vibhaagathil aantivairalukalude aagola shaasthrakaarya director merck vestt pooyint gaveshana soukaryathinte adisthaana gaveshanathinte saha-saitt medaaviyaayum avar munbu sevanamanushtichittundu.
american kemikkal sosaitti jenal oonn aanti-infective researchinteyum jenal oof vairal emittikkeshanteyum edittoriyal bordilaanu hasuda. avar munbu ucla gladston instittyoottinteyum (cafr) sentar phoor aids researchinteyum (cafr) shaasthreeya upadeshaka bordukalilum niheids research advisory kammittiyilum (arc) sevanamanushtichittundu. echu. sii. vii sahakarana gaveshana phooram, enn. sii. aii basic sciences board oof scientific kaunsilarmaar, american foundeshan phoor aids researchinte (amphor) scientific prograam advisory kaunsil ennivayile amgamaanu avar.
echuaivi-1 integrase inhibittarukalekkurichu gaveshanam.
oru retrovirus enna nilayil, echuaivikku oru rna genome undu, athu eratta-stranded dna koppiyaayi traanskript cheiyunnu, athu hoost sellinte genome ulppeduthunnu. niravadhi thudar pravarthanangalulla integrase enna ensaimaanu eee ulppeduthal nadathunnatha ithu vairal dnaude attangalumayi bandhippikkukayum oro attathuninnum rund nucleotideukal neekkam cheythukondu avaye prosess cheyyukayum cheiyunnu. hoost dnaude phosphodiistar nattelline akramikkunnathinum oru samyojana sthalathu pilarthunnathinum vairal dna strand transfer ennu vilikkunna oru ghattathil gadippikkunnathinum ithu vairal dnaude 3 'ooye sahayikkunnu. sellular ensimeukal pinneedu vidavukal niraykkunnu.
integrase inhibittarukal vikasippikkaan pravarthicha aadyatheyo eaka shaasthranjano allah hasuda. ennirunnaalum, mikka shaasthranjarum aadya gattangal thadayunnathil shradha kendreekarikkumbol (avarkk valia vijayam labhichilla), hasuda pinneedulla, straant transfer, steppil shradha kendreekarichu. eee ghattatthile inhibittarukal parishodhikkunnathin, avalkk oru puthiya parisodhana vikasippikkendivannu, athil oru plettinte kinarukalil gadippichirikkunna vairal "donner dna" anukarikkukayum taargett dna ennu label cheyyukayum cheythu. prathikarikkaattha uthppannangal kazhukimattiya sesham label cheytha dna kinattil kudungunnathiloodeyaanu integrase strand transfer pravartthanam alakkunnathu. parisodhana pravarthichu, pakshe athu labhyamaya robottukalumayi poruthappedunnilla, athinaal avarkkum rund asisttantumaarkkum 1999 ll niravadhi maasangalil 250,000 ladhikam samyukthangal kaikondu pipe cheyyendivannu.
2000-ll, avarude samgham phalapradamaaya integrase inhibittarukal nirmmikkaan kazhiyumennu kaanikkunna rund pradhana prabandhangal prasidheekarichu. thaan thiricharinja inhibittarukal integrase strand transfer inhibittaraayi (instti) pravarthikkunnuvennum vairal dna-boundu integresumaayi bandhippikkunnathaayum sajeeva saitt magneeshyam ayonukale chelettu cheiyunnathaayum athuvazhi sellular dnaumayi bandhippikkunnathil ninnu complexes thadayunnathaayum avar theliyichu. romile merck gaveshakarumaayulla sahakaranathiloode, raltegravir (icentress) kandethi-ithu yadhaarthathil heppattaitis sii polymerase inhibittaraayi vikasippicheduthirunnu, athu aaa aavasyathinu phalapradamallennu kandethi. 2007 octoberil echuaivi rogikalil upayogikkunnathinu fda ithu amgeekarichu.
bahumathikalum puraskaarangalum.
berney feeld lecture award david baari dart (development oof aanti retroviral therapes) nettatthinulla award hasudayk labhichittund. avar vikasippichedutha integrase inhibittar, icentress (raltegravir), 2008 ll prix gallion sammanam nedi. eee pravarthanatthinu avarkk itaaliyan premio galeno award labhichu. 2019ll avarkk ohiyo stettu yooniversitti vishishta gaveshana currier award nalki. 2017-ll, echu. sii. vii kompineshan therapy elbasweer/grasopreveer vikasippichathin american kemikkal sosaittiyil ninnu "heros oof kemistry" award labhicha rasathanthranjarude oru teaminte bhaagamaayirunnu avar. 2010ll american akkadami oof microbiology fellow aayi avar thiranjedukkappettu.

