
sis-lupe risapttar

nicotinic asattailkolin, gaba, gaba-ρ, glycine, 5-echu. tii. 3, sink-activated (saak) resepterukal enniva chernnathaanu sis-lupe ligand-gated ayoon chaanal suuppar famili. eee resepterukal anchu protein subunitukal chernnathaanu, avaa oru kendra sushirathinu chuttum oru pentameric krameekaranam undaakkunnu. saadhaaranayaayi 2 alfa sabyoonittukalum mattu 3 beetta, gaama allengil deltta sabyoonittukalum undu (chilathil 5 alfa subunitukal adangiyirikkunnu). 
rund sisttain (sis) avashishtangalkkidayil valare samrakshikkappetta 13 amino aasidukal roopeekarikkunna oru swabhaavasavisheshathayulla looppine kudumbatthinte peru soochippikkunnu, ithu enn-terminal extra sellular domaine sameepam oru disulfide boond roopappeduthunnu.
sis-lupe resepterukal yookkaariyottukalil maathrame ariyappedunnulloovenkilum pentameric ligand-gated ayoon chaanalukalude oru valia kudumbatthinte bhagamaanu. sis-lupe claidil maathrame bridging sisttain avashishtangal ulppedunnulloo. valia suuppar faamiliyil bacteria ulppedunnu (udha.jii. glick) athupole thanne noonn-sais-lupe eucariotic resepterukalum, ithine "pentameric ligand-gated ayoon chaanalukal" allengil "proo-lupe resepterukal" ennu vilikkunnu.
ellah upavibhaagangalilum oru valia samrakshitha extra sellular enn-terminal domaine, moonnu uyarnna samrakshitha transmembran domainukal, variable valuppathinteyum amino assid shreniyudeyum cytoplasmic lupe, thaarathamyena cheruthum variabilumaaya extra sellular sii-terminal domainullah naalaamathe transmembran mekhala enniva ulppedunnu.
neuro traansmittarukal extra sellular domainile subunitukal thammilulla interfacil bandhippikkunnu.
oro upavibhaagathilum naalu membran-spanning alfa helikkukal (m1, m2, m3, m4) adangiyirikkunnu. sushirangal pradhaanamaayum roopappedunnathu emm2 helisukalaanu. cytoskelittane bandhippikkunna intra sellular domainanu emm3-emm4 linker.
binding.
kudumbatthile vividha amgangale padikkumbol nadatthiya nigamanagalil ninnaan sis-lupe resepterukalekkurichu mikka arivum labhikkunnath. asattailkolin binding proteinukalude (eiii. sii. bii. pii) gadanakalekkurichulla gaveshanangal nirnnayikkunnath binding saittukalil aarr looppukal adangiyirikkunnu, aadya moonnu looppukal pradhana mukhavum adutha moonnu looppukal pooraka mukhavum roopappeduthunnu. pradhana mukhathe avasana lupe sajeeva resepterile ligandinu mukaliloode pothinjirikkunnu. sugandha avashishtangalum eee sthalathu daaraalamundu.
sameepakaala saahityangal soochippikkunnathu lupe biyile trp avashishtangal agonistinum ethirvashathe bandhatthinum nirnaayakamaan ennaanu. neuro traansmittarine binding saittilekk kondupookunnu, avide athu amino aasidumaayi (hydrajan, kaatteshan-π bonting ennivayiloode) samvadikkunnu, binding saittinte pradhana mukhathu sthithicheyyunna sugandha pettiyil vasikkunnu. lupe sii yill agonistum tyrosine thammilulla mattoru avashya edapedal sambhavikkunnu. prathipravartthanathil, lupe oru roopeekarana maattathinu vidheyamaakukayum binding saittile thanmatra pothiyunnathinaayi thaazhekku karangukayum cheiyunnu.
chaanal gating.
nicotinic asattailkolin resepterukalil nadatthiya gaveshanathiloode, binding gating domainukalum thammilulla alosteric edapedalukaliloodeyaanu chaanalukal sajeevamaakunnathenn nirnnayikkappettundu. agonist bandhichukazhinjaal athu roopeekarana mattangal konduvarunnu (amino-terminal domaininte oru beetta sheett neekkunnathum emm 2-emm 3 linkerumaayi bandhippichirikkunna looppukal 2, eph, sis-lupe ennivayil ninnu puratthekku neengunnathum chaanal thurakkunnathum ulppede). electron microscopy (9 Â) kaanikkunnath m2 domainile bhramanam moolamaanu thurakkunnathennu, ennaal eee resepterukalude kristtal gadanakalekkurichulla mattu padanangal kaanikkunnath thurakkunnathu oru m2 charivinte falamaayirikkaam, ithu sushirangalude valippathilekkum muzhuvan pentameric resepterinteyum kwaattenari tenilekkum nayikkunnu.