kaatekkol-ooo-methyl transferase inhibittar

kaatekkol-"oo"-methyl transferase (koomt) inhibittar kaatekkol-"oo"-methyl transferase ensaimine thadayunna oru marunnaan. eee ensime dopamine, norpinefrine, epinephrine thudangiya catecolamines methylate cheiyunnu. ithu levodopa methylate cheiyunnu. levodopa, aarometik ell-amino assid decarboxylase inhibittar (udha.jii. carbidopa allengil benzerazide). levodopa 3-"ooo"-methyldopyilekku methylation thadayunnathinulla kazhivil adhishtithamaanu oru koomt inhibittar upayogikkunnathinte chikitsa prayojanam, angane levodopa jaiva labhyatha vardhikkunnu. carbidopa/levodopa edukkunna paarkkinsans rogamulla aalukalil koomt inhibittarukal ganyamaayi samayam kuraykkunnu.
koomt inhibittarukalude pattika.
raktha-mastishka thadassam marikadakkaan kazhiyaatha peripheral inhibittarukalaanu entaakaponum opikaponum. tolcaponinu raktha-mastishka thadassam marikadakkaan kazhiyum. tolcapon kuranjathu moonnu marakamaaya marakamaaya karal thakararukalumaayi bandhappettirikkunnu, athinaal ithu apoorvvamaayi maathrame nirddeshikkappedunnal. tolcapon edukkunna rogikalkku hepatic takaraar undaayal nireekshikkanam. entaakaponum opikaponum hepatotoxisityum bandhappettitla. 

