
type II keraattin

ellah sasthanikaludeyum epithelial koshangalilum adangiyirikkunna intraasaittoplaasmaatti cytoskelittaninte type II intermediat filamentukalaanu (ifs) type II kerattinukal (allengil type II cytokeraattinukal). type 2 cytocetinukalil adisthaana allengil nishpakshavum uyarnna tanmatra bharamullathumaaya proteinukal adangiyirikkunnu, avaa vivoyil heterotypic type I, type II keraattin shringalakalude jodikalaayi krameekarichirikkunnu, lalithavum sthareekrithavumaaya epithelial tissuekkalude vyathyaasathil ithu prakadippikkunnu. manushya bhroona vikasana samayat type 1 keraattinukalkk munbu type II kerattinukal vikasippikkunnathayi kaanapedunnu.
type II cytockettinukal 12q chromosomil encode cheythirikkunnu, avaa ulkkollunnu ck1, ck2, ck3, ck4, ck5, ck6, ck7, ck8. avayude tanmatra bharam 52 kda (ck8) muthal 67 kda (ck18) vareyaanu.
mothatthil, charmmam, mudi, nakhangal ennivayude shakthiyum samagrathayum nilanirthunnathil keraattin type 2 nirnaayaka punk vahikkunnu. keraattin jeenukalile mutationukal eee tissuekale badhikkunna vividha janithaka vaikalyangalilekku nayichekkaam, udaaharanathinu epidermolysis bullosa simplexes, charmmathinteyum mucus membranukaludeyum pottukal, mannolipp ennivayaal savisheshathayulla apoorva avastha.
keraattin 2 tharangal 2a, 2b.
type II keraattinukale 2 upavibhagangalaayi thirichirikkunnu type aii. aii. eiii kerattinukal, type aii. aii. bii kerattinukal. type 2 eiii kerattinukal prakadippikkunnathu kaalukalude arakkett polulla uyarnna alavilulla mechanical sammarddam aavasyamulla tissukkalilaanu, athesamayam type 2 bii kerattinukal prakadippikkunnathu kaikalile kaippathikal polulla sammarddam kuranja tissukkalilaanu.
aii. aii. eiii kerattinukal ennu type cheyyuka.
kaalukalude arakkett allengil kaippathikal polulla uyarnna sammarddathinu vidheyamaakunna tissuekalile aavishkaaramaanu type aii. aii. eiii keraattinukalude savisheshatha. keey1, keey2, keey9, keey10, keey77, keey78 ennivayulppede manushyaril thiricharinjittulla niravadhi vyathyastha tharam 2eiii keraattinukalund. eee kerattinukal tissue-nirddishta reethiyil prakadippikkunnu, keey1, keey2, keey10 enniva pradhaanamaayum epidermisil prakadippikkunnu, athesamayam keey9, keey77, keey78 enniva neyil bedd, hair follicles ennivayil prakadippikkunnu.
type aii. aii. eiii keraattinukalkk oru savisheshamaaya gadanaaparamaaya savisheshathayundu, athu avaye coiled-koyil dimerukal roopappeduthaan anuvadikkunnu, avaa pinneedu tetramerukalaayum oduvil intermediat philamentukalaayum kootticherkkunnu. eee gadanaaparamaaya samghadana avaa prakadippikkunna tissukal anubavikkunna sammarddangale neridaan aavashyamaaya mechanical shakthiyum prathirodhasheshiyum nalkunnu. type 2 eiii keraattin jeenukalile mutationukal epidermolitic hypercaratosis (ehek), paamoplaantar keratoderma (pipike) thudangiya vividha janithaka vaikalyangalilekku nayichekkaam, iva hypercaratosis, kaippathikalilum chuvappilum charmmatthinte kumilakal ennivayaal savisheshamaan.
aibi kerattinukal ennu type cheyyuka.
charmmam, nakhangal, romakoopangal thudangiya epithelial tissuekalil praadhamikamaayi prakadippikkunna intermediat philament proteinukalude oru koottamaanu type aib kerattinukal. avaa valare samrakshikkappetta alfa-heelikkal koyil-koyil domainukalude savisheshathakalulla proteinukalude keraattin kudumbatthil pedunnu. keraattin tharam aii. aii. bii. krt6bii jeane encode cheythirikkunnu, ithu palappozhum vividha epithelial tissuekalil thulyamaaya keraattin tharam aii. aii. eiii. (krt6eiii) yumayi saha-prakadippikkunnu. eee rund proteinukalum orumichu heterodymerukal roopappeduthukayum avaa intermediat filamentukalaayi kootticherkkukayum cheiyunnu, ithu mechanical sthirathayum mechanical sammarddathodulla prathirodhavum nalkunnu. avayude gadanaaparamaaya punk koodaathe, type aib kerattinukal murivu sukhappeduthal, veekkam, koshangalude kudiyettam ennivayil pradhana punk vahikkunnathayi theliyikkappettittund. aib keraattin expression allengil krt6bii jeenile mutationukalude aniyanthrithamaaya reethi psoriasis, epidermolysis bullosa, pachyonichiya konjenitta ennivayulppede vividha charmma vaikalyangalumayi bandhappettirikkunnu.

