
sotepine

theevravum vittumaaraathathumaaya schisophreniaykku soochippikkunna oru asaadhaaranamaaya anticycotic marunnaan sotepine. 1990 muthal germmaniyilum (germmaniyil ithu nirthalaakkiyittundi) 1982 muthal jappanilum ithu upayogikkunnu.
america, yunaittad kingdom, austreliya, canada, nyoosiland ennividangalil sotepine upayogikkaan anumatiyilla.
medical upayogangal.
sottepinte praadhamika upayogam schisophreniaykkulla chikilsayaanu, ennirunnaalum nisithamaaya bipolar unmaadamulla rogikalil antimanic ejantu enna nilayil athinte falapraapthiyekkurichu klinikkal pareekshanangal nadathiyittundu (nalla phalangalode). schisophrenic lakshanagal chikilsikkunnathil phalapradamaaya 15 anticycotic marunnukalumayi thaarathamyappeduthumbol 2013 leeii oru padanatthil sotepine idatharam-sakthamaaya falaprapti prakadippichu. klosapaininekkaal phalapradamallaathathum, olaansapaininekkaalum resperidoninekkaalum alppam kuravaanu, ekadesham paaliperidon pole falapradamaanu, koodaathe haloperidol, kvettiyapain, arippiprasol ennivayekkaal alppam kooduthal falapradamaanu.
farmacology.
pharmacodynamics.
sotepaininte anticycotic prabhavam dopamine, serotonin resepterukal ennivayile ethir pravartthanatthiloode madhyasthatha vahikkunnathayi karuthappedunnu. sotepinu dii1, dii2 resepterukalumaayi uyarnna aduppamundu. ithu 5-h2a, 5-h2c, 5-h6,5-h7 resepterukale badhikkunnu. koodaathe, athinte sajeeva metabolaittaaya norsotepine sakthamaaya norpinefrine reaptekku inhibittaraayi pravartthikkunnu.
samoohavum samskaaravum.
brand perukal.
losisopilon, lodopin, settas, solepttil enniva brand namangalil ulppedunnu; ivide  ± nirthalaakkiya oru formulatione soochippikkunnu.