
beetaa-synculine

manushyaril "sncb" jeane encode cheiyunna oru proteinaan beetaa-synculine.
eee jeane encode cheytha protein alfa-synculine enna proteinode valare saamyamullathaan. eee proteinukal thalachoril dhaaraalamaayi prakadippikkukayum phospholipase dii 2 neey thiranjedutthu thadayukayum cheiyunnu. neuronal plaastittiyil oru punk vahichekkaavunna encode cheytha protein, alsheimer rogamulla rogikalude neurofibrillary shathangalil daaraalamundu. paarkkinsans rogamulla rogikalil neuronal degeneration nadakkunna pradeshamaaya thalachorile substaanshya nigrayil eee protein valareyadhikam prakadippikkunnathaayi theliyikkappettittund; ennirunnaalum, paarkkinsans rogavumaayi nerittu bandhamilla. ore protein encode cheiyunna rund traanskript vakabhedangal eee jeeninaayi kandethiyittundu.
pradhaanamaayum mastishka koshangalil kaanapedunna oru sinuklin proteinaan beetaa-sinuklin, ithu pradhaanamaayum pree synaptic terminalukalil kaanapedunnu. neocortex, hippocampus, straittam, thaalamas, cerebellum ennividangalilaanu beetaa-synculine pradhaanamaayum prakadippikkunnathu. ithu levi bodikalil kaanappedunnillenkilum pdyilum dii. ell. biyilum hippocampal paatholajiyumaayi bandhappettirikkunnu.
paarkkinsans rogam polulla neuro degenerative rogangalil sambhavikkunna alfa-sinucline aggregeshante oru inhibittaraanu beetta-sinucline. athinaal, alfa-sinuklininte neurotoxic efakttukalil ninnu kendra naadeevyavasthaye samrakshikkanum neuro degenerative disordezhsinu oru puthiya chikitsa nalkaanum beetta-sinuklin sahayikkum.

