
monode-vaiman-chanchex model

biochemistryil, monode-vaiman-chanchex model (emm. dablyu. sii model, simetri model ennum ariyappedunnu) ore upavibhagangalaal nirmmicha proteinukalude alosteric parivartthanangale vivarikkunnu. jeane-piyari chanchex thante phd theesisil ithu nirddeshikkukayum jackwus monode, jephries vaiman, jeane-piyari chanchex ennivar ithu vivarikkukayum cheythu. ithu thudar maathrkayumaayi vyathyaasappettirikkunnu.
rund vyathyastha samamiti avasthakalude ashayam emm. dablyu. sii modalinte kendra swamedhayaa aanu. niravadhi ensaimukalum resepterukalum polulla niyantritha proteinukal "oru regulatorinteyum abhaavathil" vyathyastha interconvertible avasthakalil nilanilkkunnu ennathaanu pradhana ashayam. vyathyastha roopeekarana avasthakalude anupatham nirnnayikkunnath taapa santhulithaavasthayaanu. ithu
maathruka nirvachichirikkunnathu
thaazhepparayunna niyamangal
charitraparamaaya maathrkayil, protomer (saadhaaranayaayi oru subunit ennu karuthappedunnu) ennu vilikkunna oro alosteric yoonittum rund vyathyastha roopeekarana avasthakalil nilanilkkum-'r' (relaxed) allengil 't' (tense) avasthakal. eathenkilum oru thanmathrayil, ellah protomerukalum ore avasthayilaayirikkanam. athaayath, ellah upavibhaagangalum r allengil t avasthayilaayirikkanam. vividha avasthakalil subunitukalulla proteinukal eee model anuvadikkunnilla. tii avasthayekkaal uyarnna aduppam aarr avasthaykku ligandumaayi undu. athukondaanu, ligand rund avasthakalilum aayirikkumbol subunitumaayi bandhippikkaamenkilum, oru ligaandinte binding r avasthaykku anukoolamaayi santhulithaavastha vardhippikkum. 
ligand binding saittinte (y) fraakshanal acupency (r) avasthayile proteinukalude fraction prakadippikkunna rund samavaakyangal uruthirinjekkaam
soothravaakyam _ 1
soothravaakyam _ 2
formula _ 3 alosteric sthiraankamaayirikkumbol, athaayath ligaandinte abhaavathil tii, aarr avasthakalile proteinukalude anupatham, formula _ 4 ennathu ligaandinte r, tii avasthakalude afinittikalude anupaathavum formula _ 5, ligaandinte saadhaaranamaaya saandrathayumaanu. formula _ 6-nte padaprayogam adayar samavaakyathinte oru roopamaanennu udanadi vyakthamalla, pakshe vaasthavathil, paraantheesukalile padaprayogangale gunikkunnathiloodeyum formula _ 7-nte shakthikalude gunakangale adayar samavaakyathile anubandha formula _ 8 gunakangalumaayi thaarathamyam cheiyunnathiloodeyum oraalkk kaanaan kazhiyum.
eee maathruka sigmoidal binding gunangal vishadeekarikkunnu (i.iii. positteev sahakaranasheshi) oru cheria shreniyil ligaandinte saandrathayile maattam aarr avasthayile thanmaathrakalude anupaathathil valia vardhanavinu kaaranamakum, angane ligaandinte proteinumaayi uyarnna bandhatthilekku nayikkum. negatteevu sahakaranathe vishadeekarikkaan athinu kazhiyilla.
emm. dablyu. sii model ensimologyilum farmacologyilum valare janapriyamaanennu thelinjuvenkilum oru nischitha ennam kesukalil ithu anuchithamaanennu theliyikkappettittund. haemoglobin pravartthanatthinte niyanthranamaan maathrkayude vijayakaramaya prayogatthinte ettavum mikacha udaaharanam. proteinukalude lattisukalkkaayi vividha rachayithakkal modalinte vipuleekaranangal nirddeshichittundu. thudarchayaaya modalinu cheyyaan kazhiyunnathinekkaal haemoglobin dattayekkurichu emm. dablyu. sii model mikacha vivaranam nalkunnuvennu edelstein vaadichu. adhehavum chanchex signal transductionil model prayogichu. 50 varshathinusesham modalinte avasthayekkurichu chanchex charcha cheythu.

