
jurgan noblich

oru jarmman molecular biologistaanu jurgan noblich (jananam 1963 germmaniyile memminganil). 2018 muthal viyannayile austriyan akkadami oof sayansasinte instittyoott oof molecular biotechnology (aii. emm. bii. eiii) idakkaala shaasthra directoraan addeham.   
vidyaabhyaasavum thozhilum.
tubinjen sarvakalashaalayil biochemistry lunden yooniversitti collegil molecular biology noblich padichu. 1989-ll addeham tubinganile maiks plank instittyoott phoor developmental biologyilekku maari, avide 1994-ll koshachakra purogathi niyanthrikkunnathil saiklin proteinukalude pankinekkurichulla doctoral prabandham poortthiyaakki. 1994ll saan fraansiskoyile california sarvakalashaalayil poost doctoral gaveshakanaayi. 1997 vare yuh nung jaann. europilekku madangiyethiya sesham addeham austriyayile viyannayile instittyoott oof molecular patholajiyil (aii. pii.) oru group leaderayi chernnu. 2004ll addeham viyannayile puthuthayi sthaapithamaaya instittyoott oof molecular biotechnologyilekku (aii. emm. bii. eiii) maari, avide 2005ll deputy director niyamikkappedukayum 2018ll scientific director maarukayum cheythu. aii. emm. pii. yum aii. emm. bii. eyum vienna biosentarile amgangalaanu. 2021 muthal addeham viyannayile medical sarvakalashaalayil synthetic biologyil chairmanaanu.
gaveshanathil shradha kendreekarikkuka.
noblichinte gaveshanam addehathinte poost doctoral fellow madeline eiii. yumayi chernnu aadyakaala manushya mastishka vikasanathinte oru organoid model vikasippicheduthathil prashasthamaan. laankaastar. manushyante pluri pottant stem cellukalil (ips cellukal) ninnu uruthirinja oorganooyidukal manushyarogathe maathrkayaakkaan upayogikkaamenn aadyamaayi pradharshippichathu addehathinte samghamaanu, 2013ll sayans magazin nadatthiya mikacha 10 shaasthreeya kandethalukalil ithu idam nedi.
eee maathrkaye ippol saadhaaranayaayi "cerebral oorganooyidukal" ennu vilikkunnu. ithu aadya thrimaasatthile manushya mastishka vikasanathinte aadya gattangal aavarthikkukayum mattu niravadhi gaveshana grouppukal upayogikkukayum cheythittundu. organoid modalukal eathoru manushyanil ninnum valarthaan kazhiyunna manushya koshangalil nerittu padanangal nadatthaan gaveshanangale prapthamaakkunnu. pazha eechakalil ninnum mrugangalude modalukalil ninnum gaveshana kandethalukal manushya koshangalilekku kaaryakshamamaayi kaimaran avaa shaasthranjare anuvadikkunnu, angane manushya koshangalile paarambarya janithaka mastishka rogangal anweshikkaan avaa sahayikkunnu.
2013 muthal addehathinte team cerebral oorganooyidukal vikasippicheduthittundu. rund vyathyastha paatten oorganooyidukal samyojippikkunnathiloode vyathyastha mastishka mekhalakal thammilulla edapedalukal padikkaan kazhiyumennu 2017 ll avar theliyichu.
munbu, addehathinte gaveshanam mastishka vikasanathinte samvidaanangale kendreekarichaayirunnu. neuronal stem cellukal, avayude asamamaya kosha vibhajanam, valarchaa niyanthrana prakriyakal ennivayaayirunnu avaa. thante poost doctoral pravartthanatthe adisthaanamaakki, noblichum sahapravarthakarum fruitfly drosophilayude neural stem cellukalil asamamaya stem sell vibhajanathinulla oru samboornna samvidaanathe savisheshamaayi avatharippichu. 2008-leeii koshatthile oru report ulppede, avayude phalangal seminal pepparukalude oru parambarayil prasidheekarichu. athuvare, stem sellukalkk engane svayam naveekarikkunna dotter sellayum ore samayam oru prathyeka deferentiating sellayum verthirikkaan kazhiyumennu ariyillaayirunnu. asamamaya koshavibhajanam oru prathikarana cascadine adisthaanamaakkiyullathaanu, athil tanmatra svichukalude cascade sajeevamo nishkriyamo aanu. eee cascadile proteinukal avayude phosphorylation avasthaye aashrayich orora kinace eiii ennu peritta aadyathe phoosphett avashishtam kaimaattam cheiyunna kainesil ninnu aarambhich "oonn" allengil "oof" cheiyunnu. asamamaya kosha vibhajana prakriyayil punk vahikkunna mattu thanmathrakalkkoppam tumour koshangalil orora kinace eiii palappozhum amithamaayi prakadippikkunnu. stem sell maittosis valare samrakshikkappetta prakriyayaayathinal, fruit eechakalil kaanapedunna phalangal manushyarilekku kaimaran athuvazhi pothuvaaya tumour neojenisisinekkurichu ulkkaazhcha nedaanum sahayikkunnu.
koodaathe, oru jeeviyude muzhuvan genome pravartthanangalum tissue prathyeka reethiyil oresamayam vishakalanam cheyyaan kazhiyumennu aadyamaayi theliyikkaan noblichum addehathinte samghavum aadyamaayi oru genome wide inn vivo raani screen nadatthi. ekadesham 13,000 fruit fly jeenukalil oronnum eathu koshatthilum swathanthramaayi nirjjeevamakkaan kazhiyunna baari dixon imbayil srishtikkunna oru fruit fly jeane baank upayogichaanu ithu nediyathu. eee kandethalukal 2009-ll prakrithiyil prasidheekarichu. eee reethi upayogichu, pazha eechakalile braine tumour vikasanam kooduthal vyakthamakkaan noblichinu kazhiyum. tumours stem cellukale adisthaanamaakkiyukalenayim avaa avayude savisheshamaaya stem sell swabhaavasavisheshathakal nilanirtthumennum athinaal aniyanthrithamaayi vibhajikkappedumennum sameepakaala kandethalukal soochippikkunnu, orikkalum nirddishta soomatik sell tharangalayi verthirikkappedaathe. noblichum samghavum thiricharinja braatt enna jeane moolamaanu eee vyathyaasathinte abhavam undaakunnath. manushyaril samanamaaya pravartthanamulla ethra jeenukal nilavilundennu nilavil anjjaathamaanu. bhaviyil kaansarinulla aakramanathmaka chikilsakal kuraykkunnathinu eee jeenukalil kooduthal thirichariyaan imbayile noblichinte gaveshana samgham shramikkunnu.

