
bodich prabhavam

trepe prathibhasavum trepe efakttum ennum ariyappedunna bodich ephakt, hridayamidippu vardhikkunnathinoppam myocardial tension vardhikkunna oru autoregulation reethiyaanu. 1871ll henry pickering bodich aanu ithu aadyamaayi nireekshichathu.
samvidaanam.
hridaya peshikalude koshangalude sarcoplasmic rettikulathile kaalsyatthinte saandrata vardhikkunnathum saarkoplaasathilekk athinte vardhicha prakaashanavumaan bodich efakttinte adisthaana kaaranam.
intra sellular kaalsyatthinte saandrata vardhikkunnathinulla vishadeekaranangalilonnu uyarnna hridayamidippil sodiyathinte ozhukk nilanirthaanulla Na +/k +-attu pesinte kazhivillaymayaanu. uyarnna hridayamidippu undaakumbol, udaaharanathinu adrenergic uthejanam kaaranam, ell-type kaalsyam chaanal pravartthanam vardhippichu. soodiyam-kaalsyam exchanger (koshatthil ninnu 1 caa + + ayoon ozhukunnathinupakaram 3 naa + athinte electrochemical gradient thaazhekku ozhukaan anuvadikkunnu) intra sellular kaalsyatthinte alavu kuraykkaan pravartthikkunnu. hridayamidippu kooduthal shakthamaakukayum dayastolinte neelam kurayukayum cheyyumbol, Na +/ca + + exchanger koshatthilekku konduvarunna Na + neekkam cheiyunna Na +/k +-atpes, Na + infloyude nirakkumayi poruthappedunnilla. ithu kuranja kaaryakshamamaya Na +/ca + + kaimattatthilekku nayikkunnu, kaaranam sodiyathinte gradient kurayukayum kaalsyam gathaagathathinu pinnile prerakashakthi yadhaarthathil sodiyathinte saandrata gradiantaayathinaal koshatthinullil ca + + kettippadukkunnu. ithu soodiyam kaalsyam exchanger vazhi myocardial sellil kaalsyam adinjukoodunnathinu kaaranamaakukayum cardiac glycosideukalilum kaanapedunna oru samvidaanamaaya inotropisathinte valia avasthayilekku nayikkukayum cheiyunnu.
pakaramaayi, thudarchayaayi pravartthikkunna Na +-ca + + membran exchangerinu koshatthilekku varunna ca + + neekkam cheyyaan samayam kuravaanu ennathaanu mattoru samvidaanam. positteev chronotropy diastolinte neelam kurayunnathaanu ithinu kaaranam. vardhicha intra sellular sii. eiii + + saandrathayode, oru positteev inotropy pinthudarunnu.
vardhicha hridayamidippu serca 2 eye uthejippikkunnuvennum ithu sarcoplasmic rettikulathile kaalsyatthinte ozhukkum ulladakkavum vardhippikkunnuvennum nireekshikkappettundu. serca 2 eyude eee sajeevamaakkal parokshamaayi canmoduline kinace II (camc) vazhi phospholampan (pln) phosphorilation vazhiyaan.
klinikkal praadhaanyam.
hridaya peshikalude sankochathinte shakti vardhikkunnathinaal positteev bodich prabhavam hridayathinte aouttputtil vardhanavinu kaaranamaakunnu.
eee prathibhasam saadhaaranayaayi hridayasthambhanathilum cardiomayoppathy, coronary artari rogam thudangiya hridayathinte mattu rogangalilum illa allengil vipareeta (negatteevu bodich ephakt) aanu. ithine nall allengil invezhs staircase prathibhasam ennu vilikkunnu. serca2ayile mutationukalaanu eee phalathinu saadhyathayulla kaaranam.
charithram.
1871ll henry pickering bodich aanu bodich prabhavam aadyamaayi nireekshichathu, avarude perilaanu ithu ariyappedunnathu.

