
alamethisin

trichoderma viride enna fungus ulppaadippikkunna chaanal roopappeduthunna pepttaid antibioticaanu alamethisin. ithu proteinogenic allatha amino assid avashishtamaaya aibi (2-aminoisobutoric assid) adangiyirikkunna pepttaibol pepttaidukalil pedunnu. eee avashishtam alfa-heelikkal gadanayude roopeekaranathe shakthamayi prerippikkunnu. pepttaid kramam
ivide essy = asattail, pll = fenylalaninol, aiba = 2-aminoisobutoric assid.
kosha stharangalil, naalu muthal aarr vare thanmaathrakalude samyojanathiloode ithu volteju-ashrita ayoon chaanalukal roopappeduthunnu.
jaivasamshleshanam.
1975ll aadyamaayi verthirichedutha nonribosomal pepttaid synthase (enn. aarr. pii. ezz) aaya alamethisin synthase aanu alamethisin biosynthesis uthejippikkunnathenna anumaanikkappedunnu. alamethisin pepttaidinte niravadhi sequenceukal amgeekarikkappettittundum, ivayellaam thiranjeduttha amino aasidukalil cheria vyathiyaanangalode general enn. aarr. pii. ezz samvidaanam pinthudarunnuvennu thelivukal soochippikkunnu. asattail-qoo vazhi aalm synthase ensaimil aadyathe aminoisobuteric aasidinte enn terminalinte asaileshanil ninnu aarambhich, ithine thudarnnu sinthettinte oro modular yoonittum amino aasidukalude thudarchayaaya ghaneebhavanam nadathunnu. amino aasidukal thudakkathil oru "adenililation" (eiii) domaine vazhi adenilate cheyyappedunnu, oru thaioosttar boond oru asail carrier protein polulla pepttidail carrier proteinumaayi bandhippikkunnathin munbu. valarunna shringhala amino assid vahikkunna pcpumaayi "condensation" (sii) domaine vazhi bandhippichirikkunnu, thudarnnu adutha modyoolil athe prathikaranangalude mattoru raundu.
asaadhaaranamaaya amino assid polulla substrate fenylalaninol cherthaanu assembly poortthiyaakkunnathu. fenylalaninol chertthathinethudarnnu poortthiyaaya pepttaid shringalaye theosterase domaine pilartthukayum theoster boond pilartthukayum madyam avasheshikkukayum cheiyunnu.

