oliyokaanthal

extra-virjin olivu oayil kaanapedunna oru phenylethanoid allengil oru tharam prakrithidatha phenolic samyukthamaanu oliyokaanthal. atharam enna kazhikkumbol thondayude pinbhaagathu undaakunna pollalinu ithu kaaranamaakumenn thonnunnu. oleokaanthal oru tyrosol estaraanu, athinte raasaghadana olivu ennayil kaanapedunna olyooropeenumaayi bandhappettirikkunnu.
saadhyamaaya jaivaparamaaya prathyaaghaathangal.
aanti-inflammatory.
oliyokaanthalin aanti-inflammatory, aantiooksidant gunangal inn vitro undennu kandethiyittundu. classical noonn-stiroyidal aanti-inflammatory marunnukalkk samaanamaayi, ithu cycloxyjanes (cox)-nte noonn-selective inhibittaraanu. prathidinam 50 gram (moonnara tablespoonil kooduthal) extra virjin olivu oayil muthirnnavarkkulla ibuprofen dosinte 1/10 nuu samanamaaya "inn vitro" virudha bahyaavishkaara falamullah oliyokaanthal adangiyittundu. athinaal cheria alavil deerghakaala upabhogam hrudrogathinteyum medittareniyan bhakshanavumayi bandhapetta alshimezhs rogathinteyum kuranja sambhavathin kaaranamaakumenn abhipraayappedunnu. ennirunnaalum, mikka upabhokthakkalkkum 50 gram dhaaraalam olivu oayil aanu; mathramalla, oliyokaanthalinte agiranam, metabolism, vitharanam enniva nannayi savisheshamalla, mathramalla eee "inn vitro" efakttukal yadhaarthathil shareerathil sambhavikkunnundo ennu ariyilla. "eee pashchaathalatthil, dayattari oliyokaanthalinte" "inn vivo" "virudha bahyaavishkaara phalangal beauchamb mattullavarum anumaanichathupole prasakthamalla"."
ibuprofen upayogichu sajeevamaakunna trpa 1 ayoon chaanalinte oru aaktivettaraanu oliyokaanthal. extra-virjin olivu oayil kazhikkumbol undaakunna pollalinu kaaranam oliyokaanthal aanennu kandethiyittundu.
koshajwalana degenerative joyint rogangalude chikilsayil oru chikitsa ejantaayi oliyokaanthal pravarthikkunnuvennu aduthide theliyikkappettittund. koshangalude pravarthanakshamathaye baadhikkathe, controcytukalilum macrophageukalil elps-induced ulppaadanam thadayunnathu oliyokaanthal aanu. koodaathe, ithu eiii. tii. dii. dii controcytukalilum controcytukalilum macrophageukalilum mip-1α, ail-6 marnah expression protein synthesis thadayunnu. elps-uthejippicha macrophageukalil ninnulla ail-1 bitta, tnf-α, gm-csf protein sinthasisine oliyokaanthal thadayunnu.
beetaa-amyloid.
pii-glycoprotein, elrp 1 ennivayude upgradulation vazhi β-amyloid proteinukalude shekharanam kuraykkaan oliyokaanthalin kazhiyumennu oru mruga maathrkayile padanangal soochippikkunnu.
selective cytotoxisity.
aarogyamulla koshangale kedupaadukal koodaathe upekshikkumbol "inn vitro" enna reethiyil vividatharam manushya cancer koshangale kollan oliyokaanthalin kazhiyum. apoptosis 16 muthal 24 manikkoor vare aavashyamullappol, oliyokaanthal 30 minitt muthal oru manikorinullil pravarthichu. koshatthinte maalinya uthppannangal sambharikkunna kandeynarukalaaya cancer koshangalude lysosomukaliloode koshatthe kollunna ensimeukal purathuvidunna oleeyokaanthal thulachukayarunnu. aarogyamulla koshangalil, oliyokaanthal prayogikkunnathu avarude jeevithachakrangalil thaalkkaalikamaayi nirtthivaykkaan kaaranamaayi, ennaal 24 manikkoorin sesham avaa saadhaarana nilayilekku madangi.
708 enm aisi 50 moolyamulla rapamycin (emm. tii. aarr) enna sasthanikalude lakshyathinte ensaimatik pravartthanatthe oliyokaanthal thadayunnu. dosine aashrayich kuranja micromolar saandrathayil niravadhi stanarbuda koshangalude valarchaye oliyokaanthal thadayunnu. oliyokaanthal chikitsa metaastaattik stanarbuda kosharekhayil (emm. dii. eiii-emm. bii-233) phosphorylated emm. tii. aarinte ganyamaaya niyanthranam kuraykkaan kaaranamaayi. eee phalangal shakthamayi soochippikkunnathu emm. tii. aarr inhibition ennathu oliyokaanthalinte report cheyyappetta aanti cancer, neuroprotective gunangalude gadakangalilonnaanennu.
lysosomal membranine accredine ooranchu upayogichu chikilsichaanu sell apoptosis parishodhikkunnath. accredine ooranchu oru lysosomil kedupaadukal sambhavikkatha vardhicha saandrathayil chuvanna fluorescent niram vikiranam cheiyunnu. apoptosisine soochippikkunna chuvanna fluorescent niratthe oliyokaanthal durbalappeduthunnu; ennirunnaalum, kaansarillaatha koshangalkk apoptosis anubhavappedilla. cancer koshangalude maranathe prothsaahippikkunna lysosome membran permiabilisationte falamaanithu. cancer ithara koshangalil oliyokaanthal lysosomal membran permiabilisation sajeevamakkunnilla.
pala kosha tharangalude vyaapanathin kaaranamakunna oru pradhana tyrosine kainas resepteraaya sii-mettine thadayunna inn vitroy oliyokaanthal kaanichittundu. eee phalangal kandethiya athe padanatthil 48 manikorinullil aarogyakaramaya niyanthrana koshangalil oliyokaanthalin doshakaramaaya phalangalonnum illennu kaanichu, emby-223 stanarbuda koshangalil sii-mettu thadayaan edutha athe samayam. samayam ghattathil koshangal sell saikkil arast cheyyaan nirbandhitharaakunnu, ithu eee uyarnna aakramanathmaka kosharekhayude pravarthanakshamathaye phalapradamaayi kuraykkunnu.
saadhyamaaya medical upayogangal.
nilavil ithu oru marunnayi nalkunnillengilum, "sii-mettu" ennathinte oru cheria marunnu inhibittaraayi oliyokaanthaline upayogikkunnathinum "heridari jinchival fibromatosis" (echgf), sii-mettu ennivaykkethiraaya monoclonal antibodiyaayi upayogikkaan saadhyathayulla niravadhi thanthrangal padichuvarikayaanu.

