
esmirtasapine

urakkamillaaymayudeyum vasomotor lakshanangaludeyum (udha.jii.aarthavaviraamavumaayi bandhapetta choodulla minnalukal). mirtaasaapaininte ("s")-(+)-enantiomeraanu esmirtasapine, koodaathe echu1,5-echu2 resepterukalil invezhs agonist pravartthanangalum α2-adrenergic resepterukalil ethir pravartthanangalum ulppede samanamaaya mothatthilulla farmacology undu. 
prathyekichu, aarr-myrtasapine, racemic misritham ennivayumaayi thaarathamyappeduthumbol, esmirtasapinu ekadesham 10 manikkoor dairkhyamulla ardhaayuss undu, ithu 18-40 manikkoor dairkhyamullathaanu. urakkamillaaymayude chikilsaykkaayi kuranja alavil (3-4.5 milligram) esmirtaasaapininekkur merck niravadhi padanangal nadathiyittundu. ithu sakthamaaya echu1-inhibittarum 5-echu2eiii aantagostiyumaanu ennathinaal urakkamillaayma chikilsikkaan ithu aakarshakamaan. kuranja alavil mirtasapinil ninnu vyathyasthamayi, ardhaayuss (10 manikkoor) adutha divasathe mayakka marunnu kaikaaryam cheyyaan kazhiyunnathra cheruthaanu, ennirunnaalum, janasamkhyayude valiyoru bhagamaaya saip 2 dii 6 polymorphysamulla aalukalkk, ardhaayuss alppam kooduthalaayirikkumennu prathekshikkunnu. thangalude oru padanatthil adutha divasathe mayakkathinte sambhavam oru prashnamallenn merck gaveshakar avakashappettu, ennaal eee avakaashavaadam chodyam cheyyappettittund (15 sathamaanam rogikalum pakal urakkathekkurich paraathippedukayum placibo groupile 3.5 sathamaanam perr paraathippedukayum cheythu).
2010 maarchil, "thanthraparamaaya kaaranangalal", hoott flashukalkkum urakkamillaaymaykkum vendi merck esmirtasaapaininaayulla aantharika klinikkal vikasana paripadi avasaanippichu.

