
bhraanthante pothuvaaya parasis

general paralysis, general paralysis oof dhaa insen (gpi), paralytic demensia, allengil syphilatic paresis ennum ariyappedunna general paresis, oru oorgaanik mental desorder ennu tharamthirickunna gurutharamaaya neuro psychiatric disorderaanu, ithu chikilsayillaathe vidumbol rogathinte eee avasana ghattavumayi bandhappettirikkunna avasana ghatta syphilis, vittumaaraatha meningoensephalitis, cerebral atrophy enniva moolamaanu undaakunnath. gpi verum paaresisil ninnu vyathyasthamaan, kaaranam verum paresis mattu onniladhikam kaaranangalal undakam, saadhaaranayaayi vaijnjaanika pravartthanatthe baadikkilla. gpi moolamundaakunna degenerative mattangal praadhamikamaayi frondall, temporal lobber courtexumaayi bandhappettirikkunnu. syphilis baadhichavaril ekadesham 7 sathamaanam pere eee rogam badhikkunnu, samayabandhithamaya chikilsaykku kurachu oopshanukal labhyamaya moonnaam loka rajyangalil ithu valare saadhaaranamaanu. purushanmaarilaan ithu kooduthalaayi kaanappedunnath.
pathonpathaam noottaandinte thudakkathil aadyamaayi thiricharinjappol, oru malinamaaya swabhaavam kaaranam gpi yadhaarthathil oru tharam bhranthaayi kanakkaakkappettirunnu. 1880kalude avasaanathilaanu sifilisumaayulla eee avasthayude bandham kandethiyathu. kramena, salverson, neosalverson (1910) thudangiya jaiva aarsenikkalukalude kandethal, pyrotherapy vikasanam (1920), syphilis chikilsayil pensilinte vyapakamaaya labhyathayum upayogavum (1940) enniva eee avastha ozhivakkaavunnathum chikilsikkaavunnathumaayir. ithinu munbu, gpi anivaryamaayum maarakamayirunnu, ithu pothu manoroga aashupathrikalile thaamasakkaarude praadhamika roganirnayathinte 25 sathamaanam vare aayirunnu.
adayaalangalum lakshanangalum.
anubaadhaykk sesham 10 muthal 30 varsham vareyaanu rogathinte lakshanagal aadyam prathyakshappedunnathu. ksheenam, thalavedana, urakkamillaayma, thalakarakkam thudangiya neuresthenic budhimuttukaliloodeyanu insipiyant gpi saadhaaranayaayi prakadamaakunnathu. rogam purogamikkumbol, maanasika thakarchayum vyakthithva maattangalum sambhavikkunnu. saamoohika thadassangal nashtappeduka, saamoohika perumaattam, kramena vidhinyaya vaikalyam, eakaagratha, hraswakaala oormma, aanandam, unmaadam, vishaadam allengil udaseenata enniva saadhaarana lakshanangalil ulppedunnu. sookshumamaaya virayal, samsaarathile cheria vaikalyangal, aargil robartsan puple enniva sradheyamaayekkaam.
rogam purogamikkumbol saadhaaranamaaya vyaamohangal moshamaayi chittappedutthiyathum asambandhavumaanu. avaa gambheeramo vishaadamo bhraanthamo aakam. eee vyaamohangalil valia sambathu, amarthyatha, aayirakkanakkin premikal, agadhamaaya shakti, apocalypsis, shoonyatha, svayam kuttabodham, svayam kuttam allengil vichitramaaya hypocondriakal paraathikal enniva ulppedunnu. pinneedu, rogikk disarthria, intentt tremers, hyperreflexia, myoclonic jerkkukal, ashayakkuzhappam, apasmaram, kadinamaaya peshi kshayam enniva anubhavappedunnu. oduvil, palappozhum apasmaraavasthayil kidappilaya, kaashettik, poornnamaayum dishaabodham illaathaaya avasthayil paaretik marikkunnu.
roganirnayam.
aii puple reflexukalile (aarjil robartsan puple) savisheshamaaya asaadhaaranathakal, oduvil, muscular reflex asaadhaaranathakal, apasmarangal, memory vaikalyam (demensia), thaarathamyena vyapakamaaya neuroseribral thakarchayude mattu lakshanagal enniva vazhi roganirnayam mattu ariyappedunna psychosukalil ninnum demensiakalil ninnum verthirichariyaan kazhiyum. cerebrospinal draavakathinte vishakalanatheyum siphilisinulla parisodhanakaleyum adisthaanamaakkiyullathaanu krithyamaaya roganirnayam.
pravachanam.
rogalakshanangalkk shamanam labhicha kesukal rekhappeduthiyittundu, prathyekichu avaa psychosis ghattathinappuram kadannupoyillengil, eee vyakthikalkk kurachu maasangal muthal kurachu varshangalkkullil mikkavarum sthiramaayi aavarthanam anubhavapettu. allaathapaksham, rogalakshanathinte sankeernnatha, theevratha, niyanthrikkaanaavaatha enniva kaaranam rogikk apoorvvamaayi maathrame veettilekku madangaan kazhinjulloo. oduvil, rogi poornnamaayum kazhivillaathavanaayithirum kidakkayil kidannu marikkukayum cheyyum, eee prakriyaykku sharashari moonnu muthal anchu varsham vare edukkum.
charithram.
munkaala padanangal ithe thakaraarullathinte munkaala sambhavangal kandethiyittundengil, bhraanthanmaarkkidayil vyakthamaayi thiricharinja paaresisinte aadya udaaharanagal nepolian yudhangalkku sesham paareesil vivarikkapettu. 1822ll aantoyin laurent jessy beylaanu bhraanthante pothuvaaya paaresisine aadyamaayi oru prathyeka rogamaayi visheshippichathu. 20 num 40 num idayil praayamulla aalukale (sthreekalekkaal purushanmaaraan kooduthal) general paresis badhikkunnu. udaaharanathinu, 1877 aayappozhekkum newyorkkile purushanmarkkulla oru abhayakendrathinte suuprand thante sthaapanathil eee takaraar 12 sathamaanathiladhikam praveshanathinum 2 sathamaanathiladhikam maranangalkkum kaaranamaanennu report cheythu.
swabhaavathinteyo bharanaghadanayudeyo antharleenamaaya balaheenathayaan kaaranam ennu thudakkathil vishwasichirunnu. syphilis general parasis (purogamana pakshaaghaatham) undaakkunnuvenn 1857-ll thanne friedrich voonn esmark saikyaatristum vaadichirunnuvenkilum, eee aashayathinte medical samooham pothuvaayi amgeekarikkunnathilekkula purogathi 19-aamm noottaandile prashastha syphilographer jeane alfred fornier (1832-1914) maathramaan poortthiyaakkiyathu. 1913-ll hydeo noguchiyum jeey. yum chernnu paresisinte syphilitic swabhaavathekkurichulla ellah samshayangalum oduvil illaathaakki. dablyu. muur paarettiksinte thalachorile syphilitic spirocheettukal pradharshippichu.
1917-ll juuliyas wagner-jaureg malaria baadhicha rogikale badhikkunna malaria therapy (eee saahacharyathil, oru panii medical induction) general paaresisinte purogathi thadayaan kazhiyumennu kandethi. eee kandethalinu 1927-ll addehathinu nobal sammanam labhichu. randaam lokamahaayudhathinushesham syphilis chikilsikkaan pensilin upayogikkunnathu general paaresisine apoorvvamaakki yadhaartha general paaresisinte aadyakaala lakshanagal prakadippikkunna rogikalkku polum pensilin kozhs upayogichu poornnamaayi sukham prapikkaan kazhinju. vikaswara raajyangalkk purathu eee rogam ippol phalatthil anjjaathamaanu, avide polum epidemiology ganyamaayi kuranju.
general paaresisile chila sradheyamaaya kesukal

