
mevalonic assid

biochemistry oru pradhana jaiva samyukthamaanu mevalonic assid (mva); dihydroxymethylate sankochamaanu peru. jaiva paristhithiyile pradhana roopamaaya mevalonic aasidinte carboxylate ayoon "mevalonettu" ennariyappedunnu, ithu pradhana farmaceutical praadhaanyamullathaanu. echmji-qoo reductase thadayunnathiloode mevalonate uthppaadanam thadayunna stattinukal (collustrollinte alavu kuraykkunnava) polulla marunnukal.
rasathanthram.
mevalonic assid vellathilum dhruva jaiva laayakangalilum valare layikkunnu. athinte terminal alcoholinteyum carboxylic assid functional grouppukaludeyum aantharika ghaneebhavanathiloode roopappedunna mevalonolactone ennariyappedunna laakton roopavumaayi ithu santhulithaavasthayilaanu. echmji qoo-eiii reductase mutation moolamundaakunna stattin linked mayoppathi, limb girdil muscular disease enniva sariyaakkaan mevalonolactone pravartthikkunnu.
jeevashasthram.
terpeneukalum stiroyidukalum uthppaadippikkunna mevalonettu pathway ennariyappedunna biosynthetic paathayile oru mungamiyaanu mevalonic assid. isopentanail pyrophosphettinte (aii. pii. pii) praadhamika munnodiyaanu mevalonic assid, ithu ellah terpenoidukalkkum adisthaanamaanu. mevalonic assid chiral aanu, (3 "r")-enantiomer maathramaan jaivashaasthraparamaayi sajeevamaayath.