
trifluoro operasetic assid

trifluoro operasetic assid (trifluoro operasetic assid, tii. eph. pii. eiii. eiii) oru oorgaanofloorin samyukthamaanu, trifluoroasetic aasidinte peroxy assid analog, ghaneebhavicha gadanaaparamaaya soothravaakyamullathaanu. kettonukalude bair-williger ooksideshanukal polulla jaiva ooksideshan prathikaranagalkkulla sakthamaaya ooksidaising ejantaanithu. ithu jaiva peroxy aasidukalil ettavum prathipravarthanakshamaanu, ithu mattu peroxy aasidukal phalapradamallaatha epoxideukalilekku thaarathamyena prathipravarthanarahithamaaya aalkkeenukale vijayakaramaayi ooksidais cheyyaan anuvadikkunnu. selenoitherukale selonukalaayi parivartthanam cheiyunnathiloode chila pravartthana grouppukalile chalcojansine ooksidais cheyyaanum ithinu kazhiyum. ithu sphodakavasthukkalaakan saadhyathayullathum vaanijyaparamaayi labhyamallathathumaaya oru vasthukkalaanenkilum aavashyamullappol vegathil ithu thayyarakkam. oru laborattari riyejant enna nilayil athinte upayogam vilyam dii aanu thudakkamidukayum vikasippikkukayum cheythath. emmons.
swathukkal.
saadhaarana anthareeksha thapanilayilum marddathilum, trifluoro operasetic assid 162 digri selshyas thilanilayulla niramillaatha draavakamaanu. asettonitrail, dichloromethain, diethyl eedhar, sulfolane ennivayil layikkunna ithu vellavumayi eluppathil prathipravartthikkunnu. ellah peroxy aasidukaleyum pole, ithu spodanaathmakamaanu, shradhaapoorvvam kaikaaryam cheyyendathundu. ithu vaanijyaparamaayi labhyamallengilum labil nirmmikkanum −20 digri selshyasil aazhchakalolam sookshikkaanum kazhiyum. chila thayyaareduppukal sheshikkunna hydrajan peroxide trifluoroasetic assid adangiya mishrithangalkk kaaranamaakunnu, atharam misritham choodaakkunnathu angeyattam apakadakaramaanu; choodaakkunnathinu munbu surakshaykkaayi hydrajan peroxide manganese dye ooksaid upayogichu vighadippikkaam.
thayyaareduppu.
hydrajan peroxide saandramaaya (90 sathamaanam) jaleeya layani upayogichu trifluoroasetic unhydride chikilsikkunna oru "oorgaanik synthesis" prakriyayiloode trifluoroperasettic assid eluppathil thayyarakkam
jalavumaayi sanbarkkam pulartthumbol unhydride trifluoroasetic assid roopappeduthumennathinaal, unhydride adhika alavu peroxide reactantil ninnu laayakathe neekkam cheyyaanum sahayikkunnu
trifluoroasetic aasidil ninnulla chila prathikaranangalkk trifluoroperasettic assid roopeekarikkaan kooduthal nerppicha hydrajan peroxide layani (30 sathamaanam) upayogikkaam.
hydrajan peroxide shudhamo uyarnna saandrathayullatho aaya laayanikal kaikaaryam cheiyunnathinulla apakadam ozhivakkaan, hydrajan peroxide-euria peraxid nalkaan upayogikkaam. eee reethiyil vellam ulppedunnilla, athinaal ithu poornnamaayum anhydrus perasid nalkunnu, ithu chila ooksideshan prathikaranangalil jalathinte saannidhyam paarshwapravartthanangalil nayikkumbol oru nettamaanu.
oru sinthasisinu oru piechu buffering ejantu aavasyamulla saahacharyangalilum jalathinte saannidhyam sahikkavunna saahacharyangalilum mattoru sameepanam vikasippicheduthittundu. soodiyam perkaarbanettumaayi trifluoroasetic unhydride prathipravartthikkunnathu, trifluoroperasettic assid soodiyam kaarbanettum nalkunnu, ithu oru adhika bafarinte aavasyakatha ozhivaakkunnu.
trifluoro operasetic assid "inn sittuvil" srishtikkaanum kazhiyum, ithu pinneedu upayogathinaayi reactorinte oru baachu munkootty samanvayippikkunnathinum taargett substrateumaayi vegathil prathikarikkaan anuvadikkunnu.
upayogikkunnu.
trifluoro operasetic assid praadhamikamaayi oru ooksidaising ejantaayi upayogikkunnu. 1953 septambaril "jenal oof dhii american kemikkal sosaitti" vilyam dii. yude kruthi prasidheekarichu. emmansum arther eph. inn sittu" aayi uthppaadippikkunna eee reactorinu anilyn nitrobenzinaayi ooksidais cheyyaan kazhiyumennu ferris report cheythu. thudarnnulla rund varshangalil, eee reactorinaayi oru thayyaareduppu reethi report cheytha emmons, athinte prayogangalekkurichu eee jenalil aarr kayyezhuthuprathikal koodi prasidheekarichu; oru laborattari reactoraayi trifluoro operasetic aasidinte thudakkakkaaranum developer aayi emmons bhaagikamaayi oormmikkappedunnu, ithu pinneedu vividha tharatthilulla synthetic prathikaranangalkk oru reactoraayi upayogapradamaayi.
acidity avasthakalil hofmann punakrameekaranam nadatthaan upayogikkunna hypervaalant iodine samyukthathinte roopeekaranamaanu oru udaaharanam. hypervaalant samyuktham rund tharatthil axus cheyyaavunnathaanu, eathu thiranjedukkunnathu saadhaaranayaayi labhyamaya vasthukkale aasrayichirikkunnu oru exchange prathikaranatthiloode athinte asattett analogil ninnu allengil trifluoro operasetic aasidinteyum trifluoroasetic aasidinteyum samyojanathode iodobenzene prathipravarthippichundu ithu thayyarakkam
bair-williger ooksideshan.
samanamaaya peraasidukalumaayum peroxideukalumaayum thaarathamyappeduthumbol uyarnna acidity ullathinte anantharafalamaayi bair-williger ooksideshanukalkku upayogikkunna ettavum sakthamaaya reactorukalil onnaanu trifluoro operasetic assid. eee prathikaranam kettonukale strait-cheyin esttarukalo lactonukalo aakki maattunnu, 1899 ll aadyamaayi report cheytha adolph voonn beyarinteyum victor villiyarinteyum perilaanu ithu ariyappedunnathu. prathikaranam oru kreeji intermediattiloode thudarumennu vishwasikkappedunnu, koodaathe ooksijan aattam ulppeduthunnathinulla sthaanathinu nalla rejiyoselaktivittiyum keemoselectivittiyum pradarshippikkunnu, oppam aduthulla sthaanathu stereochemistry nilanirthukayum cheiyunnu, inipparayunna udaaharanathil kaanaan kazhiyum. uyarnna acidity ulla trifluoroasetic assid upolppannam esttar uthppannathinte jalavishleshanathino transasterificano kaaranamaakunnath thadayunnathinaayi disodium phoosphett () oru piechu bafaraayi cherkkunnu.
epoxidation.
1909ll aadyamaayi report cheyyappetta oru peraxid ooksidantaayi upayogichu oru alkeene epoxidelake parivartthanam cheiyunnathu preleshave prathikaranatthil ulppedunnu. tropain alcaloidaaya scopin sinthasisinte avasana ghattamayi eee prathikaranam upayogichu. eee sameepanathil, dairon nonacarbonyl madhyasthatha vahikkunna oru cycloload cyclic asthikoodam nirmmikkaan upayogikkunnu, disobutiluminium hydride upayogichu keettoninte diasterioselective reduction vazhi hydroxyl functional group avatharippikkukayum prilashev trifluoro operasetic assid epoxidation upayogichu thayyarakkukayum cheiyunnu.
mattu peroxy aasidukalumaayi thaarathamyappeduthumbol trifluoro operasetic aasidinte uyarnna prathipravartthanam thaarathamyena electron-paavar aalkkeenukalaya 1-hexin, α, methyl methacrylate polulla β-ansaachurettad esttarukal, peroxy-assid epoxidatione saadhaaranayaayi prathirodhikkunna substrateukal enniva vijayakaramaayi ooksidais cheyyaan anuvadikkunnu. mishrithatthile adhika buffered trifluoroasetic assid ulppeduthunnathu epoxidene pakaram oru visinal hydroxy-trifluoroasettett ghadana nalkunnu, ithu acidic methanol upayogichu chikilsikkunnathiloode diolelake parivartthanam cheyyaan kazhiyum, udaaharanathinu 1-dodessine 1,2-dodecanediolilekku parivartthanam cheiyunnu.
oru sameepakaala carbonyl functional groupulla oru allail alcohol samyukthathinte kaaryatthil, epoxidene oru ring-vipuleekarana prathikaranatthinu vidheyamaayi oru dioxolane roopappedaam. chuvadeyulla prakriya oru prakrithi ulppannamaaya neosporolinte motham samanvayathinte bhaagamaayi upayogichu
isomeric samyukthamaaya sporol thayyarakkunnathil samanamaaya dioxolane roopeekaranam ulppedunnu. eee saahacharyathil, hydrajan peroxidil ninnu uruthirinja trifluoro operasetic aasidinte upayogam, athinaal jalathinte adayaalangal adangiyirikkaam, clossed-ring dioxoleyninekkaal kooduthalum oru hemiyaasettal nalki. jalarahithamaya vasthukkal nalkia euria samuchayathinte upayogam dioxolane pradhana ulppannamaayi vijayakaramaayi nalki. sinthasisile pilkkala ghattathil sporolil kaanapedunna 1,3-dioxane systethilekku dioxolane vikasippikkunnu.
hetteroaattam ooksideshan.
kuranja ooksideshan avasthakalil hetteroaattangal adangiyirikkunna pravartthana grouppukale trifluoro operasetic assid upayogichu ooksidais cheyyaan kazhiyum. ayodinte ooksideshan (udaaharanathinu, neratthe soochippicha iodobenzinil ninnu hypervaalant iodine samyukthathinte roopeekaranam), naitrajan, sulfur, selenium enniva saadhaarana kesukalil ulppedunnu.
naitrajan adangiya samyukthangalude kaaryatthil, ariyappedunna parivartthanangalil ooksaimukalum sugandha praadhamika aminukalum naitro samyukthangalilekkulla parivartthanangalum ulppedunnu (electron-valikkunna pakarakkarumaayi polum, udaaharanathinu, pentafluoroanilin muthal pentafluoronitrobenseinse vare), nitrosaaminukal nitraaminukalilekkulla, sugandha "enn"-ooksaidukaludeyum sugandha assain "enn"-ooksaidukaludeyum roopeekaranam, naitro samyukthangale naitro samyukthangalilekko nitraaminukalilekko parivartthanam cheyyuka. udaaharanathinu, hydrajan peroxidinteyum trifluoro operasetic aasidinteyum misritham nitroso-pakaramulla pyrimidine 4,6-diamino-5-nitrosopyrimidine-2-theoline athinte naitro analogilekku ooksidais cheiyunnu, athesamayam auxidative hydrolytic desulferisation vazhi theol bhagam neekkam cheiyunnu
chalkojan moolakangalude kaaryatthil, sulfide moyittikal (aarr-ezz-aarr) trifluoro operasetic assid upayogichu sulfoxide (aarr-ezz (oo)-aarr), koodaathe/allengil salphon (aarr-ezz (oo) 2-aarr) roopangalaayi ooksidais cheyyaan kazhiyum. analogus selenium sisttathil, selinoitharukalude (aarr-seey-aarr) trifluoro operasetic assid ooksideshan, bandhapetta selenoxideukalude (aarr-seey (ooo)-aarr) roopeekaranamillaathe selonukal (aarr-seey (ooo) 2-aarr) uthpaadippikkunnu, ithu oru verthirichedukkaavunna ulppannamaanu, ithu aarr oru aaril grooppaayirikkumbol prathyekichum phalapradamaaya oru prathikaranamaanu. sulfinal chlorideukalude (rs (oo) sii. ell) roopeekaranathinulla oru pothuvaaya sameepanam sulfuril chloridemaayulla () theolinte prathikaranamaanu. pakaram sulfanyl chloride (aarr. ezz. sii. ell) undaakunna sandarbhangalil, thudarnnulla trifluoro operasetic assid ooksideshan aavasyamulla uthppannam nalkunnu, <aii. dii. 1>-trifluoro-1,1-diphenyltheniyolinte kaaryatthilennapole
theopheninte trifluoro operasetic assid ooksideshan prathikaranatthinulla malsaraadhishtitha paathakale chithreekarikkunnu, athil "s"-ooksideshanum epoxidation saadhyamaan. pradhana paatha thudakkathil sulfoxide roopappeduthunnu, ennaal kooduthal ooksideshan sambhavikkunnathin munbu eee rasavasthu udanadi oru dials-alder-type dimerisation vidheyamaakunnu-theophene-"s"-ooksaid allengil theophene-"s", "s"-dye ooksaid enniva prathikaranatthinte uthppannangalil kaanapedunnilla. diamerine kooduthal ooksidais cheyyaanum "s"-ooksaid moyittikalilonnu "s", "s"-dye ooksaidaayi parivartthanam cheyyaanum kazhiyum. cheria prathikarana pathayil, oru preleesev epoxidation theophene-2,3-epoxide roopappedunnathinu kaaranamaakunnu, athu theophene-2-vann enna isomerilekku athivegam punakrameekarikkunnu. trapping pareekshanangal eee epoxide paatha "s"-ooksaid intermediattinte oru badal prathikaranamallennu theliyikkunnu, koodaathe isotopic labeling pareekshanangal 1,2-hydride shift (oru nih shift) sambhavikkunnuvennum angane oru catanic intermediat ulppedunnuvennum theliyikkunnu. orupakshe oru malsaraadhishtitha aditharayaayi pravarthikkunnathinaal vellam cheria prathikarana paathaye adichamarthunnathinaal trifluoro operasetic assid thayyarakkal reethi thiranjedukkunnathu pradhaanamaan.
acidity punakrameekaranathodukoodiya ooksideshan.
boron trifluoridenoppam trifluoro operasetic assid upayogikkunnathu alkkeenukaludeyum sugandha valayangaludeyum ooksideshanum tanmatra asthikoodathinte anubandha punakrameekaranathinum kaaranamaakunnu.
aalkkeenukalkk, prathikaranam oru kettoon uthppannam nalkunnu, ennirunnaalum yaanthrika prakriya kevalam epoxidation mathramalla, thudarnnu bf 3-catalised wagner-meerveen punakrameekaranamaanu
sugandhashaasthrathe sambandhichidatholam, hexamethylbenzene 2,3,4,5,6,6-hexamethyl-2,4-cyclohexadianon aayi parivartthanam cheiyunnathaanu oru "oorgaanik synthesis" reportil pradharshippichirikkunna oru udaaharanam
arinukalude auxidative villal.
carbonyl samyukthangal roopappeduthunnathinaayi sugandha valayangalude lalithamaaya ooksideshanu purame, trifluoro operasetic aasidinu valayathinullile kaarban-kaarban bondukale poornnamaayum vighadippikkaan kazhiyum. alchylaromatic gadanakalude mattu ooksideshanukalil ninnu vyathyasthamayi, reactive benzylic sthaanathu alkail cheyin pilarnnu benzoic aasidukalum anubandha samyukthangalum nalkunna trifluoro operasetic assid oru "vipareeta ooksideshanu" kaaranamaakunnu, alkail groupine kedukoodaathe vidumbol sugandha valayathe thanne pilartthunnu.
chila tharatthilulla bondukalude eee selectivity gadanaaparamaaya vishadaamshangal nirnnayikkunnathinaayi kalkari polulla hydrocarbonukalude sankeernamaaya mishrithangal vighadippikkaan ithu anuvadikkunnu.
hetteroaattangal adangiya sugandha samvidaanangal eee ring thurakkunnathine prathirodhikkunnu, kaaranam hetteroaattom ooksideshan mungananayode sambhavikkukayum peroxy aasidinte electrophilic aakramanathilekku ring nirjjeevamaakkukayum cheiyunnu. udaaharanathinu, purinukal, pyridinukal, kvinolinukal enniva pakaram "enn"-ooksaidukal undaakkunnu, athesamayam octafluorodybensothian polulla sulfur samvidaanangal sulphonukalaayi parivartthanam cheyyappedunnu.
ring-activating substituntukallu sugandha samvidaanangal ring-ooppaning prathikaranatthinu vidheyamakunnathinupakaram phenolukal roopappeduthunnathinaayi ooksidais cheyyaan kazhiyum. udaaharanathinu, mesittileen trifluoro operasetic aasidumaayi prathipravartthichu mesittol (2,4,6-trimethylphenol) roopappedunnu. 7-oxodasettamidocolchinte bair-williger ooksideshan vazhi oru laakton roopappeduthaan shramicha gaveshakarkk aavasyamulla uthppannam thayyarakkan kazhinjilla, pakshe uyarnna vilavil oru phenol-derivative uthppaadippikkunnathina sugandha valayathinte ooksideshan nedi

