
adenosine kinnez

adenosine kinnez (aeye. dee. key.; ee. see. 2.7.1.20) ack enzyme haye joe adenosine trifosphate (aeye. tii. pee.) seey adenosine (aeye. dee. oh.) mein gaama-phosphat key hastaantaran koo utprerit kartaa haye jisase adenosine monofosphate (aeye. pee.) kaa gathan hotaa haye. edo kii koshikiya sandrata koo niyantrit karane mein isaki achchi tarah seey adhyayan kii gaee bhoomika key alawa, aeye. dee. key. methylation pratikriyaon key rakharkhaav mein bhee mahatvapurna bhoomika nibhaata haye. koshikaon mein sabhi aiss-adenosylmethionine-nirbhar transmethylean pratikriyaon seey aiss-adenosylhomosistine (sah) kaa utpaadan hotaa haye, jise sah hydrolege dwara edo aur homocystein mein vibhajit kiya jaataa haye. inn antim utpaadon koo kushalata seey hataane mein viphalata (aeye. dee. key. dwara phosphorylation dwara aeye. dee. oh. koo hataa diyaa gayaa) key parinamswarup saah kaa nirmaan hoe sakata haye, joe sabhi transmethyl pratikriyaon kaa ack shaktishali avarodhak haye. choohon mein aeye. dee. key. jeane (-/-) kaa vyavadhaan navjat yakrit steatosis kaa kaaran banata haye, ack ghaatak sthiti joe teji seey microvasicular vasaa ghuspaith kii visheshta haye, jisase prasav key baad kii mrityu hoe jaati haye. inn jaanvaron mein yakrit mukhya anga thaa joe prabhaavit huaa aur isamen adenine nucleotide kaa star cumm hoe gayaa, jabaki saah key star koo badhaaya gayaa. haal hii mein, manushyon mein aeye. dee. key. jeane mein missense utparivartan, jisake parinamswarup aeye. dee. key. kii kamee hoti haye, hypermethionemia, encephalopathy aur asamanya yakrit kaary kaa kaaran bhee saabit huaa haye.
jaiv rasayanik guna.
aeye. dee. key. ack monomeric protein (~ 38-40 key. dee. aeye.) haye, joe ack aadeshit dwi-dwi-pratikriya tantra key madhyam seey kaam kartaa haye. yeh cheeni sambandhak phosphophructokines bee (pee. aff. key. bee.) parivaarasan sambandhit achhi. iss parivaar key anya sadasyon (jinhen aar. key. parivaar key roop mein bhee jaanaa jaataa haye) mein ribokinaaz (aar. key.), innocin-guanosine kinnez, fructokinaaz aur 1-phosphophructokinas shamil hain. pee. aff. key. bee./aar. key. parivaar key sadasyon kii pehchaan teen sanrakshit anukram rupankanon kii upasthiti seey kii jaati haye. aeye. dee. key. aur protein key kaee anya pee. aff. key. parivaar kii sanrachanaon koo kaee jeevon (neeche khand dekhein) key saath-saath ee. seey aar. key. protein key liye nirdhaarit kiya gayaa haye. kolai. aeye. dee. key. aur protein key anya pee. aff. key. bee. parivaar key beach cumm anukram samaantaa key bavjood, yeye protein sanrachanaatmak staron parr kaafee samaan hain. edk key liye joe yaugik substrate hain unamen aine-nucleosides toyokamycin, tubersidine aur 6-methylmecaptopurin riboside shamil hain; see-nucleosides formaisin aeye, 9-azedenosine, aur badee sankhya mein anya see-aur aine-nucleoside analogue shamil hain. standhari sroton seey aeye. dee. key., aeye. dee. oh. key aeye. tii. pee.-nirbhar phosphorylation koo puuraa karane key alawa, aeye. dee. pee. kii aavashyakta vaali aeye. dee. pee.-aeye. pee. pee. vinimay pratikriya koo bhee utprerit kartaa haye. yeh gatividhi aeye. dee. key. kaa ack abhinn hissa haye aur yeh sambhavatah koshikaon mein edo ekagrata key teji seey aur sateek niyantran kii anumati detaa haye. vibhinn sroton seey aeye. dee. key. kii enzymatic gatividhi phosphat (paaee) aur/yaa pentavalent ayanon parr ack chihnit nirbharta dikhaati haye aur yeh protein key pee. aff. key. bee. parivaar kii ack sanrakshit sampatti haye. sanrakshit nxxe rupankan, joe protein key pfkb parivaar kaa ack vishisht guna haye, paaee (pvi) nirbharta mein shamil haye.
protein key pee. aff. key. bee. parivaar key saath vikas aur sambandh.
aeye. dee. key. jeane/protein mukhya roop seey eukariotic jeevon mein paaya jaataa haye aur iska praathamik anukram sanrakshan kii uchch degree (> 55% aeye. aeye. samaantaa) dikhaata haye. haalaanki, aeye. dee. key. anukram cumm (~ 20-25%) pradarshit karate hain, lekin protein key anya pee. aff. key. bee. parivaar jaise aar. key. aur phosphophructokines key saath mahatvapurna samaantaa haye, joe procariotic jeevon mein bhee paae jaate hain. halanki mycobacterium tuberculosis mein ack protein joe aeye. dee. key. gatividhi kaa pradarshan kartaa haye, iss enzyme key anukram aur jaiv rasayanik visheshtaon seey pataa chalata haye kii yeh ack asamanya enzyme haye joe anya aeye. dee. key. (24 pratishat seey cumm) kii tulanaa mein ribokinez aur fructokinez (35 pratishat) seey adhik nikatata seey sambandhit haye.
jeane aur isophorm.
manushyon mein aeye. dee. key. jeane 10 kyu. 11-10 kyu. 24 kshetra mein gunasutra 10 parr sthit haye. isake coding anukram (lagbhag 1 key. bee.) key vipareet, standhari prajaatiyon mein aeye. dee. key. jeane asamanya roop seey badaa haye (manushyon mein ~ 546 key. bee.) aur isamen 11 exon (lambai mein 36 seey 173 bee. pee.) aur 10 intron hotey hain jinaki lambai 4.2 key. bee. seey 128.6 key. bee. (ausat ~ 50 key. bee.) taka hoti haye. maanav aeye. dee. key. (> 550) key liye gair-coding aur coding anukram kaa anupaat kissy bhee jeane key liye sabse adhik gyaat haye. standhari jeevon mein aeye. dee. key. jeane koo aeye. dee. key. key lambe isophorm key liye jeane seey sir seey sir key tareeke seey jodaa jaataa haye, aur yeye donon jeane ekal dwi-dishaatmak pravartak seey lipyantarit hotey hain. aeye. dee. key. jeane kaa badaa aakar aur iska jeane seey judaav, joe kii amneots (ee.) key liye vishisht visheshta haye.jee. vibhinn standhari, pakshi aur sarisrip). isake vipareet, anya eukariotic jeevon mein aeye. dee. key. jeane lambai mein bahut chhote hotey hain (1.3-20 key. bee. lambe). standhaariyon mein, edak key dou isophorm maujood hotey hain. yeye donon samroop apani javic gatividhi mein koee antar naheen dikhaate hain aur way kewal aine-terminus parr bhinn hotey hain jahaan lambe samroop (aeye. dee. key-long) mein atirikt 21 emino acid hotey hain joe laghu samroop (aeye. dee. key-short) key pahale 4 emino acid koo pratisthaapit karate hain. yeye donon samroop swatantra roop seey pratilekhan star parr viniyamit hotey hain aur laghu samroop key liye pravartak pahale badey aeye. dee. key. intron key bheetar sthit hotaa haye. haal hii mein yeh dikhaaya gayaa thaa kii dou aeye. dee. key. isophorm mein seey, aeye. dee. key.-lamba isophorm naabhik mein sthaaniyakrit haye, jabaki aeye. dee. key.-short koshika dravya mein paaya jaataa haye.
cardio-aur neuro-surakshaatmak bhoomikaaen.
aeye. dee. key. aeye. dee. oh. key koshikiya star koo niyantrit karane mein ack kendriya bhoomika nibhaata haye, joe standhari ootakon mein adenosine receptors key saath apani baatchit key madhyam seey shaktishali cardioprotective aur neuroprotective gatividhiyon sahit shaaririk pratikriyaon kii ack vistrit shrinkhala kaa utpaadan kartaa haye. mastishk mein aeye. dee. key. kii atee-abhivyakti, jisase edo star mein kamee aatee haye aur astrocytes dwara neuronal uttejana key avrodh kii haani hoti haye, koo mirgi kii pragati key mukhya antarnihit kaaran key roop mein prastaavit kiya gayaa haye. isaliye, baahari madhyamon seey edke kaa modulan isake sambhaavit chikitsiya laabhon kaa upayog karane key liye ack mahatvapurna ranneeti pradaan kartaa haye. iss prakaar, aeye. dee. key. key vishisht avrodhakon koo vikasit karane mein bahut ruchi haye. kaee aeye. dee. key. avarodhak, jinamen seey kuchh pashu model mein upayogi analgesic, anty-seasure aur anty-inflammatory guna dikhaate hain, kaa varnan kiya gayaa haye.
utparivarti standhari koshikaon key saath adhyayan.
samvardhit standhari koshikaon mein, mukhya roop seey cheeni hamster andashay (chou) koshikaon mein, kaee prakaar key utparivarti joe aeye. dee. key. mein prabhaavit hotey hain aur unake aanuvanshik aur jaiv rasayanik gunon mein dilchasp antar dikhaate hain, unhein alag kiya gayaa haye; ack prakaar kaa utparivarti joe asamanya roop seey uchch sahaj utparivarti aavritti (10− 3-10 − 4) parr praapt kiya jaataa haye, aeye. dee. key. jeane key bheetar badey vilopan hotey hain joe kaee intron aur exon key nuksan kii or leey jaate hain. kaee utparivarti joe donon aeye. dee. key. isophorm kii abhivyaktiyon kii abhivyakti mein prabhaavit hotey hain, unhein bhee alag kiya gayaa haye.

