
aff-boxes protein 15

aff-boxes protein 15 jise aff. bee. aiks. 15 key roop mein bhee jaanaa jaataa haye, ack protein haye jise manushyon mein aff. bee. aiks. oh. 15 jeane dwara kootbaddh kiya jaataa haye.
kaary.
aff-boxes protein parivaar key sadasya, jaise kii aff. bee. aiks. oh. 15, lagbhag 40-emino acid aff-boxes rupankan dwara chihnit hain. aiss. see. aff. parisar, joe aiss. key. pee. 1, cullin aur aff-boxes protein dwara banaae jaate hain, protein-ubiquitin ligses key roop mein kaary karate hain. aff-boxes protein aff boxes key madhyam seey aiss. key. pee. 1 key saath baatchit karate hain, aur way anya protein antahkriya kshetron key madhyam seey sarvavyaapi lakshyon key saath baatchit karate hain.
jaiv rasayanik roop seey, aff. bee. aiks. 15 aff-boxes protein key parivaar seey sambandhit ack ubiquitin ligage kaa ack substrate receptor haye. anya aff-boxes proteins seey alag, aff. bee. aiks. 15 apane substrate kiff1-binding protein (key. bee. pee.) koo acetylation parr nirbhar tareeke seey pahachaantaa haye.
bhroon stame koshikaon mein mahatva.
aff. bee. aiks. oh. 15 ack protein haye joe avibhajit bhroon stame koshikaon mein vyakt kiya jaataa haye.
yeh auct 3/4, see-mike, klf 4 aur sox 2 key saha-abhivyakti key dauran vyakt kiya jaataa haye, bhroon stame cell aatm-navikaran aur vibhedan daman mein mahatvapurna honey key liye pehchaane gaye chaar jeane.
choohe mein beeta-galactosidase jeane aff. bee. aiks. 15 locus mein giraa, aiss koshikaon, praarambhik bhroon (dou-koshika seey blastocyst charanon taka), aur vrishan ootak mein daag kaa pataa chalaa.
aff. bee. aiks. 15-encoding pratilekhan jeane key oopar kii or ack samvardhak sthal haye jisamen ack octamer-jaise bandhan rupankan aur ack sokes-jaise bandhan rupankan shamil haye. reporter jeane vishleshanon ney pradarshit kiya kii aiss koshika-vishisht abhivyakti key liye iss 18-bee. pee. badhaane vaale tatva kii aavashyakta hoti haye joe pratilekhan deeksha sthal seey lagbhag 500 nucleotide oopar kii or sthit hotaa haye. kissy bhee rupankan koo hataane yaa bindu utparivartan ney samvardhak gatividhi koo samaapt curr diyaa. yeh nih 3tii3 koshikaon mein sakriya hoe gayaa jaba auct3/4 aur aiss. oh. aiks. 2 koo saha-abhivyakt kiya gayaa aur sahyogaatmak roop seey samvardhak anukram seey jodaa gayaa.
choohon mein "fbx15" jeane key lakshit vilopan key parinamswarup bhroon kii ghaataktaa yaa sakal vikasatmak vichalan naheen hotaa haye, iss tathya key bavjood kii "fbx15-/-" choohon koo unake jangli prakaar key samkakshon kii tulanaa mein upa-upajaau maanaa jaataa haye. ise iss tathya seey samajhaaya jaa sakata haye kii "fbx15-/-" bhroon stame koshikaaen ack prasaar dosh pradarshit karati hain-joe fbx15 substrate kbp key sanchay key kaaran hoti hain-joe bhrunjanan key shuruati charanon key dauran ack alpakaalik baadha utpann karati hain. vaastav mein, ack anirdhaarit mitochondrial biogenesis koo rokane key liye key. bee. pee. kaa lakshyikaran aavashyak haye, joe kii, saral pluripotent stame koshikaon mein, mitochondrial oxidative phosphorylation aur pratikriyaasheel oxygen prajaatiyon key utpaadan mein vriddhi kaa kaaran banata haye.
aff. bee. aiks. 15 kii chayanaatmak abhivyakti aur pluripotency core karakon kii gatividhi parr isaki nirbharta auct 3/4 aur aiss. oh. aiks. 2 ney aff. bee. aiks. 15 kii abhivyakti key upayog koo prerit pluripotent stame koshikaon mein fibroblast key punah prograam karane key pahale marker key roop mein badhaava diyaa.

