
mycolic acid

mycolic acid mycolata taxon kii koshika divaaron mein paae jaane vaale lambe vasaayukt acid hain, bacteria kaa ack samooh jisamen "mycobacterium tuberculosis" shamil haye, joe roga kaa kaarak haye. way mycolata prajaatiyon kii koshika deewaar kaa pramukh ghatak hain. unake naam key bavjood, mycolic acid kaa kavak seey koee javic sambandh naheen haye; naam philamentus upasthiti seey utpann hotaa haye unaki upasthiti uchch aavardhan key tahat mycolata detee haye. koshika deewaar mein mycolic acid kii upasthiti bhee mycolata koo ack vishisht sakal aakriti vigyaan visheshta detee haye jise "cording" key roop mein jaanaa jaataa haye. mycolic acid koo pahale stodola aur anya dwara alag kiya gayaa thaa."1938 mein" "aim" "key ack ark seey. tapedik ".
mycolic acid ack lambi beeta-hydroxy shrinkhala seey baney hotey hain jisamen ack chhoti alfa-alkyle side chain hoti haye. pratyek anu mein 60 seey 90 carbon paramanu hotey hain. carbon kii sateek sankhya prajaatiyon key anusaar bhinn hoti haye aur iska upayog pehchaan sahaayata key roop mein kiya jaa sakata haye. adhikansh mycolic acid mein vibhinn karyatmak samooh bhee hotey hain.
aim" key mycolic acid. tapedik ".
"aim. tapedik teen mukhya prakaar key mycolic acid kaa utpaadan kartaa haih alfa-, methoxy-aur keeto-. alfa-mycolic acid jeev key mycolic acid kaa cumm seey cumm 70 pratishat banaate hain aur isamen kaee cyclopropen ring hotey hain. methoxy-mycolic acid, jisamen kaee methoxy samooh hotey hain, jeev mein mycolic acid kaa 10 pratishat seey 15 pratishat key beach hotaa haye. shesh 10 seey 15 pratishat mycolic acid keeto-mycolic acid hotey hain, jinamen kaee keaton samooh hotey hain.
mycolic acid "aim" pradaan karate hain. advitiya gunon key saath tapedik" joe chikitsa upchaar koo nakaartaa haye. way jeev koo rasayanik kshati aur nirjalikaran key liye adhik pratirodhi banaate hain, aur hydrophilic antibiotic davaaon aur biosides kii prabhavsheelta koo seemit karate hain. mycolic acid bhee jeevaanu koo macrophage key ander badhane kii anumati dete hain, joe ise prabhaavi roop seey mezban pratiraksha pranali seey chhipaate hain. micholate jaiv sanshleshan "aim" key astitva aur rogjanan key liye mahatvapurna haye. tapedik ". maarg aur enzymon koo spasht kiya gayaa haye aur vistaar seey bataaya gayaa haye. paanch alag-alag charan shamil hain. inca saransh iss prakaar thaah
macolic acid kaa utpaadan karane vaale fatty acid synthes-aaee aur fatty acid synthes-aaee maarg beeta-ketoacil-(asyl-carrier-protein) synthes-iii enzyme dwara judey hotey hain, jinhen aksar mtfah key roop mein naamit kiya jaataa haye. iss enzyme key nae avrodhakon kaa sambhaavit roop seey chikitsiya agents key roop mein upayog kiya jaa sakata haye.
mycolic acid soojan koo niyantrit karane key dilchasp guna dikhaate hain. prayogaatmak asthama mein praakritik mycolic acid dwara ack spasht sahishnu pratikriya koo badhaava diyaa gayaa thaa. halanki praakritik ark rasayanik roop seey visham aur soojan vaale hotey hain. javic sanshleshan dwara, praakritik mishran seey vibhinn samroopataon koo shuddh roop mein praapt kiya jaa sakata haye aur javic gatividhi key liye pareekshan kiya jaa sakata haye. ack upavarg poori tarah seey nae tareeke seey damey kaa bahut achchha damnak saabit huaa. inn yaugikon kii abb aage kii jaanch kii jaa rahee haye. ack dusare upavarg ney ack cellular pratiraksha pratikriya (th1 aur th17) koo trigger kiya, isaliye teekaakaran key liye ack sahayak key roop mein iss upavarg kaa upayog karane key liye adhyayan jaari hain.
mycolic acid kii sateek sanrachana jeev key vishaaktata seey nikatata seey judee hui prateet hoti haye, kyonki anu key karyatmak samoohon key sanshodhan seey "inn vivo" key vikas mein kamee aaa sakati haye. isake alawa, mycolic acid sanshleshan key liye jimmedaar jeane mein utparivartan vaale vyakti parivartit crum kaa pradarshan karate hain.
naidaanik prasangikta.
ack antarrashtriya bahu-kendra adhyayan ney saabit kiya haye kii delamanid (oh. pee. see.-67683), nitro-dihydro-imidazozole varg key yaugikon seey praapt ack nayaa agent joe mycolic acid sanshleshan koo rokta haye, 2 maheene mein bahu-dawa-pratirodhi tapedik (aim. dee. aar. tii. bee.) mein thook samvardhan roopaantaran kii darr koo badhaa sakata haye.
rhodococcus" sp key mycolic acid..
mycolata taxon key ack anya sadasya, "rhodococcus" vansh key sadasyon key mycolic acid, "aim" seey kaee tarikon seey alag hotey hain. tapedik ". unamen koee karyatmak samooh naheen hotey hain, lekin isake bajaay kaee asantript bandhan hoe sakate hain. rhodococcus" mycolic acid key dou alag-alag profile maujood hain. pahale mein 28 aur 46 carbon parmaanuon key beach yaa tou 0 yaa 1 asantript bandhan hotey hain. dusare mein 34 aur 54 carbon parmaanuon key beach 0 aur 4 asantript bandhan hain. sutcliffe (1998) ney prastaav diyaa haye kii way arabinoglacton anuon dwara shesh koshika deewaar seey judey hue hain.