
phospholipase aeye1

phospholipase aeye1 (ee. see. <aaee. dee1>; vyavasthit naam phosphatidilcoline 1-asylhydroles) jise plaa1aeye jeane dwara kootbaddh kiya gayaa haye, ack phospholipase enzyme haye joe 1-asil samooh koo hataa detaa haih 
yeh ack enzyme haye joe phospholipase naamak enzymon key ack varg mein rahata haye joe phospholipids koo fatty acid mein hydrolyse kartaa haye. chaar varg hain, joe pratikriya key prakaar key anusaar alag kiye gaye hain joe way utprerit karate hain. vishesh roop seey, phospholipase aeye1 (pee. ell. aeye. 1) vishesh roop seey phospholipids kii "aiss. aine"-1 sthiti mein daraar koo utprerit kartaa haye, jisase ack vasaayukt aml aur ack lysophospholipid banata haye.
kaary.
pee. ell. aeye. 1. manushyon sahit kaee prajaatiyon mein maujood hain, aur inmein vibhinn prakaar key koshikiya kaary hain jinamen lysophospholipid madhyasthon key utpaadan kaa viniyaman aur suvidha, aur paachan enzymon key roop mein kaary karna shamil haye. yeye enzyme cellular phospholipids kii teji seey karobar darr key liye jimmedaar hain. isake alawa, plaa1 dwara utprerit pratikriya key utpaad joe ack vasaayukt aml aur ack lysophospholipid hain, vibhinn javic karyon jaise platelet ektrikaran aur chikani maanspeshiyon key sankuchan mein mahatvapurna hain. isake alawa, lysophospholipids khaadya takneekon aur saundarya prasadhanon mein surfactant key roop mein paae jaa sakate hain, aur dawa vitaran mein upayog kiye jaa sakate hain. choonki pee. ell. aeye. 1 kaee prajaatiyon mein paaya jaataa haye, isaliye yeh paaya gayaa haye kii adhyayan kiye jaa rahey jeev key aadhar parr iss ack vishisht enzyme key vibhinn varg hain.
prajaati aur ootak vitaran.
plaa1 mein kaee bhinnataaen hain, joe pratyek jeev mein maujood haye. vishesh roop seey, yeh standhari koshikaon jaise choohe key yakrit aur gojaatiya mastishk key plasma mein paaya jaa sakata haye, aur metazone parjivi, protozoa parjivi aur saamp key jahar mein bhee paaya jaa sakata haye.
substrate vishishtata.
plaa1 aayanyukt substrate kii tulanaa mein gair-aayanit substrate koo adhimaantah hydrolyse kartaa haye. tatasth phospholipids parr pee. ell. aeye. 1 gatividhi key liye ishtatam pee. aich. sthitiyaan lagbhag 7.5 hain, jabaki amleeya phospholipids parr pee. ell. aeye. 1 gatividhi key liye ishtatam sthitiyaan lagbhag 4 hain.
sanrachana.
ack plaa1 kii sanrachana ack monomer haye jisamen nimnalikhit anukram hotaa haih gly-aiks-sair-aiks-gly, jahan aiks kissy anya amino acid kaa pratinidhitva kartaa haye. serin koo enzyme mein sakriya sthaan maanaa jaataa haye. plaa1 mein sair-asp-hizz kaa ack utprerak trayi bhee hotaa haye, jisamen dysulphide bandhan key gathan key liye aavashyak vibhinn prakaar key cysteine avashesh hotey hain. cysteine avashesh pramukh sanrachanaatmak rupankanon jaise kii dhakkan kshetra aur bee9 kshetra key liye jimmedaar hain, joe donon lipid binding satah loop hain. yeye dou loop pratyek plaa1 key beach bhinn hoe sakate hain. udaaharan key liye, ack lambe dhakkan domen (22-23 amino acid) key saath ack plaa1 enzyme aur ack lambe bee9 domen (18-19 amino acid) ack extracellular plaa1 kaa gathan karate hain joe tricylglycerol hydroless gatividhi kaa pradarshan kartaa haye. isake vipareet, ack pee. ell. aeye. 1 enzyme jise adhik chayanaatmak maanaa jaataa haye, mein ack chhota dhakkan aur bee9 domen hoga joe kramshah 7-12 aur 12-13 emino acid kaa vistaar kartaa haye.
audyogik upayog.
anya phospholipaces jaise kii plaa2 key vipareet, iss enzyme koo shuddh karane, clone karane, vyakt karane aur visheshta bataane key liye kissy bhee kushal tareeke kii kamee key kaaran plaa1 key baare mein bahut kuchh agyaat haye. pee. ell. aeye. 1 vartamaan mein isake kaaran vyaavsaayik roop seey upalabdh naheen haye. lysophospholipids khaadya takneekon aur saundarya prasadhanon mein surfactants key roop mein paae jaa sakate hain, aur dawa vitaran mein upayog kiye jaa sakate hain. pee. ell. aeye. 1 utpaadan key liye upayukt vikas vatavaran nirdhaarit karane key liye vartamaan shodh kaa upayog kiya jaa rhaa haye. ack vishesh adhyayan mein, yeh paaya gayaa kii pee. ell. aeye. 1 kaa utpaadan aiss. dwara kiya jaa sakata haye. serevisia "aur" aeye. oriza ". inn pee. ell. aeye. 1. utpaadak sanskritiyon mein, nitrogen aur carbon sroton koo badhaane seey pee. ell. aeye. 1. kii paidawar mein vriddhi hoe sakati haye.
khoj.
1900 key dashak kii shuruat mein, ack avalokan kiya gayaa thaa, jisamen phosphatidilcoline key saath agnyashay key russ key ushmaayan key baad mukt vasaa acid kaa sanchay dikhaaya gayaa thaa. dekhaa gayaa kii pee. ell. aeye. 1 gatividhi kaa pahala mamla 1903 mein thaa jaba saamp key jahar koo phosphatidilcoline koo lysophosphatidilcoline mein badalane key liye paaya gayaa thaa, jise isake ack fatty acid key binaa phosphatidilcoline key roop mein paribhaashit kiya gayaa haye. 1960 key dashak mein, yeh paaya gayaa kii enzyme iss vasaayukt aml key daraar koo kaee tarikon seey utprerit karate hain, jinamen seey ack "aiss. aine."-1 sthiti haye. iss vishesh pratikriya koo plaa1 dwara utprerit kiya jaataa haye, jabaki "aiss. aine."-2 sthiti parr pratikriya koo phospholipase aeye2 dwara utprerit kiya jaataa haye.