
sarvavyaapi-sanyugmak enzyme

ubquitin-sanyugmit enzyme, jinhen ee2 enzyme key roop mein bhee jaanaa jaataa haye aur shayed hii kabhi ubquitin-vaahak enzyme key roop mein jaanaa jaataa haye, sarvavyaapi pratikriya mein doosara charan karate hain joe proteojom key madhyam seey ksharan key liye ack protein koo lakshit kartaa haye. sarvavyaapi prakriya sahsanyojak roop seey 76 emino acid kaa ack chhota protein, ubquitin koo lakshit protein parr ack lycine avashesh seey jodati haye. ack baar jaba ack protein koo ack ubquitin anu key saath tagg kiya jaataa haye, tou sarvavyaapeeta key atirikt daur ack polyubiquitin shrinkhala banaate hain jise proteojom key 19 key niyaamak kann dwara pahachaana jaataa haye, joe lakshit protein key atp-nirbhar unfolding koo trigger kartaa haye joe proteojom key 20 key core kann mein jaane kii anumati detaa haye, jahaan protease lakshya koo koshika dwara punarchakran key liye chhote peptide tukadon mein vikrit curr dete hain.
sambandh.
ack ubquitin-sakriya karane vaalaa enzyme, yaa ee1, pahale anu koo usake sakriya site cysteine avashesh seey sahsanyojak roop seey jodkar ubquitin koo sakriya kartaa haye. sakriya ubiquitin koo phir ee2 cysteine mein sthanantarit curr diyaa jaataa haye. ack baar ubquitin mein sanyugmit honey key baad, ee2 anu sanrachanaatmak roop seey sanrakshit bandhan kshetra key madhyam seey kaee ubquitin ligses yaa ee3 mein seey ack koo baandhata haye. ee3 anu lakshit protein substrate koo baandhane aur ubquitin koo ee2 cysteine seey lakshit protein parr ack lycine avashesh mein sthanantarit karane key liye jimmedaar haye.
ack vishesh koshika mein aamtaur parr kewal kuchh prakaar key ee1 anu, ee2aiss kii adhik vividhata aur ee3aiss kii bahut badee vividhata hoti haye. manushyon mein, lagbhag 30 ee2 hain joe 600 + ee3 mein seey ack key saath juda sakate hain. iss prakaar, substrate kii pehchaan aur bandhan key liye jimmedaar ee3 anu protesomal ksharan mein substrate vishishtata key tantra hain. pratyek prakaar kaa ee2 kaee ee3 key saath juda sakata haye.
ee2aiss kaa upayog protein folding tantra kaa adhyayan karane key liye bhee kiya jaa sakata haye. choonki sarvavyaapi pranali sabhi jeevon mein saajha kii jaati haye, isaliye adhyayan samagr pranali koo samajhane key liye sanshodhit ee2 protein kaa upayog curr sakate hain kii sabhi jeev protein koo kaise sansaadhit karate hain. kuchh protein bhee hain joe donon key roop mein kaary curr sakate hain aur ee2 aur ack ee3 jisamen domen hotey hain joe ee2 aur ee3 donon karyakshamta koo shamil karate hain.
isozyme.
nimnalikhit maanav jeane ubquitin-sanyugma enzymon koo kootbaddh karate hainh

