
lima domen

limm domen protein sanrachanaatmak domen hain, joe dou sannihit jastaa ungaliyon seey baney hotey hain, joe dou-emino acid avashesh hydrophobic linker dwara alag kiye jaate hain. domen naam una teen jeenon kaa sankshipt naam haye jisamen ise pahali baar pahachaana gayaa thaa (linn-11, isl-1 aur mec-3). lima ack protein antahkriya kshetra haye joe sanrachanaatmak aur karyatmak roop seey vividh bhagidaron key liye badhyakari haye. lima domen eukariotes mein paudhon, kavak, amiba aur jaanvaron key sabse haal key samanya poorvaj seey kuchh samay pahale dikhaai diyaa thaa. pashu koshikaon mein, limm domen yukt protein aksar koshika naabhik key beach shuttle karate hain jahaan way jeane abhivyakti koo niyantrit curr sakate hain, aur koshika-dravya jahaan way aamtaur parr koshikaon koo ack saath jodane mein shamil actin cytoskeletal sanrachanaon aur aspas key matricks seey judey hotey hain, jaise kii tanaav fiber, fokal adhession aur paalan junction.
khoj.
teen homeobox protein mein unaki praarambhik khoj key baad lima domen kaa naam rakhaa gayaa haye jinake nimnalikhit kaary hainh
anukram aur sanrachana.
manushyon mein 73 varnit jeane hotey hain joe vibhinn limm domen yukt protein koo encoding karate hain. inn limm domen mein jastaa bandhan mein shamil kuchh pramukh avasheshon key alawa alag-alag amino acid anukram hotey hain, joe ack sthir protein core aur tritiyak taha key gathan kii suvidha pradaan karate hain. vibhinn seemit kshetron key beach anukram bhinnata sanrakshit sthir core key sheersh parr vividh bhagidaron key liye nae bandhan sthalon key vikas key kaaran hoe sakati haye. isake alawa, limm domen protein karyatmak roop seey vividh hain; vishesh roop seey jaanvaron key praarambhik vikas key dauran, limm domen naee karyakshamta key saath inn vividh proteins koo banaane key liye vibhinn prakaar key anya domen prakaron key saath punah sanyojit hotaa haye.
lima domen kaa anukram hastakshar iss prakaar haih
[c]-[x] 2-4-[c]-[x] 13-19-[w]-[h]-[x] 2-4-[c]-[f]-[lvi]-[c]-[x] 2-4-[c]-[x] 13-20-c-[x] 2-4-[c]]
limm domen aksar gunakon mein hotey hain, jaisa kii tess, ell. aim. oh. 4 jaise protein mein dekhaa jaataa haye, aur unhein ack bandhan yaa lakshyikaran kaary pradaan karane key liye anya domen seey bhee jodaa jaa sakata haye, jaise kii limm-kinnez.
bhoomikaaen.
koshika-asthipanjar sangathan, anga vikas, paadap koshika vikas key viniyaman, koshika vansh vinirdesh aur jeane pratilekhan key viniyaman mein protein yukt limm-domen koo bhoomika nibhaate hue dikhaaya gayaa haye. limm protein hriday aur maanspeshiyon kii vibhinn sthitiyon, oncogenesis, tantrika sambandhi vikaaron aur anya beemariyon mein bhee shamil hain. lima-domen kaee alag-alag cellular prakriyaon mein vibhinn prakaar key protein-protein antahkriyaon mein madhyasthata karate hain. haalaanki, ack yaantrik bhaar key tahat actin cytoskeletal sanrachanaon key liye limm protein key ack badey upasamuchchay kii bharti kii jaati haye. lima dwara pratyaksh bull-sakriya aff-actin bandhan, tanaavgrast cytoskeletal network key liye limm domen protein kii bharti kartaa haye aur ack yantrikikaran tantra kaa ack udaaharan haye jisake dwara cytoskeletal tanaav yaantrik homeostasis, paramanu sthaaniyakaran, jeane abhivyakti aur anya koshikiya shareer vigyaan koo niyantrit kartaa haye.
vargeekaran.
jeane key limm superclass koo 14 vargon mein vargeekrit kiya gayaa haih ablim, crop, anigma, applin, lasp, lhx, lmo, limak, lmo7, mikal, pxn, pinch, tess aur jikes. inmein seey chhah varg (i.ee.ablim, mikal, anigma, jikes, lhx, lm07) jaanvaron key mool vansh mein utpann huaa, aur maanaa jaataa haye kii iss vistaar ney pashu bahukoshikta kii utpatti mein ack pramukh yogdan diyaa haye.
jaanvaron kii vanshavali key alawa, yojana limm jeane kaa ack puuraa varg haye jise chaar alag-alag vargon mein vargeekrit kiya gayaa thaah doubleu. ell. aaee. aim. 1, doubleu. ell. aaee. aim. 2, plim 1, plim 2, aur flim (aiks. ell. aaee. aim.). inhen 4 alag-alag upa-parivaaron mein vargeekrit kiya gayaa haih αlim1, βlim1, γlim2, aur δlim2. αlim1 upa-varg mein plim1, doubleu. ell. aaee. aim1, aur flim (xlim) shamil hain. βlim1 ack nayaa upa-parivaar haye, isaliye koee vartamaan bhed karane yogya upa-varg naheen haye. γlim2 upkhand mein Wlim2 aur plim2 hotey hain. antim upa-parivaar δlim2 mein Wlim2 aur plim2 hotey hain.
limm domen vibhinn jeevaanu vanshavali mein bhee paae jaate hain jahan way aamtaur parr ack metallopeptidase domen mein fuse kiye jaate hain. kuchh sanskaran apane aine-terminus parr ack nishkriya pee-loop ntpage aur ack ekal transmembrane helix key liye fusion dikhaate hain. inn domen fusions seey pataa chalata haye kii procariotic lima domen koshika jhilli mein protein prasanskaran koo niyantrit karane kii sambhavana rakhate hain. domen vaastushilp vakyavinyas bee-boxes jink finger aur aine1 jink finger domen key procariotic sanskaranon key samanantar haye.
protein yukt limm domen koshikaon mein kaee vishisht karyon koo puuraa kartaa haye jaise kii followers junction, cytoarchitecture, koshika dhruviyata kaa vinirdesh, paramanu-cytoplasmic shuttle aur protein taskari. yeye kshetra eukario, paudhon, jaanvaron, kavak aur mysetozoa mein paae jaa sakate hain. ise aeye, bee, see aur dee key roop mein vargeekrit kiya gayaa thaa. inn vargeekaranon koo aage teen samoohon mein vargeekrit kiya gayaa haye.
samooh 1.
iss samooh mein seemit domen varg aeye aur bee shamil hain. way aam taur parr anya karyatmak kshetron jaise kii kinnes mein fuse kiye jaate hain. inn kshetron key liye upavarg hain-limm-homodoman pratilekhan kaarak, ell. aim. oh. protein aur limm kinnes.
limm-homodoman pratilekhan kaarak.
unamen bahu-karyatmakta mukhya roop seey tantrika tantra key vikas, pratilekhan key sakriyan aur vikas key dauran koshika bhaagya vinirdesh parr dhyaan kendrit karati haye. tantrika tantra tantrika-samvaahak jaiv-sanshleshit maargon key vibhedan key liye seemit kshetra prakaar parr nirbhar kartaa haye.
ell. aim. oh. protein.
yeye protein kaee prakaar kii koshikaon key samagr vikas key saath-saath oncogenesis aur pratilekhan viniyaman parr dhyaan kendrit karate hain. tii-cell leukemia rogiyon mein ell. aim. oh. 1 aur ell. aim. oh. 2 kii abhivyakti key kaaran oncogenesis paaya gayaa thaa.
seemit sambandh.
inn proteins kaa uddeshya cytoskeleton kii sthaapana aur viniyaman haye. inn sambandhakon dwara cytoskeleton kaa viniyaman coffilin key phosphorylation key madhyam seey hotaa haye, joe actin tantuon key sanchay kii anumati detaa haye. vishesh roop seey, way koshika gatishilata aur roopjanan key viniyaman key liye jimmedaar paae gaye hain.
samooh 2.
iss samooh mein limm domen varg see hotaa haye, joe aamtaur parr koshika dravya mein sthaaniyakrit hotey hain. inn domen koo prati protein dou pratiyon key saath aantarik roop seey dohraya jaataa haye. saath hii, way aeye aur bee varg kii tulanaa mein pratyek key samaan hain.
cysteine seey bharpur protein.
teen alag-alag cysteine samriddh protein hain. inn proteins kaa uddeshya myogenesis aur maanspeshiyon kii sanrachana mein unaki bhoomika haye. haalaanki, yeh paaya gayaa kii sanrachanaatmak bhoomika kaee prakaar kii koshikaon mein nibhai jaati haye. pratyek see. aar. pee. protein poore myogenesis mein sakriya hotey hain. see. aar. pee. 3 myoblast key vikas mein bhoomika nibhaata haye, jabaki see. aar. pee. 1 fibro blast koshikaon mein sakriya haye. crop 1 mein actin filaments aur myofibers kii jaid lines key saath adhik bhoomikaaen shamil hain.
samooh 3.
iss samooh mein kewal varg dee hotaa haye, joe aamtaur parr koshika dravya mein sthaaniyakrit hotey hain. inn limm protein mein 1 seey 5 domen hotey hain. inn domen mein atirikt karyatmak domen yaa rupankan hoe sakate hain. yeh samooh teen alag-alag anukoolak proteins taka seemit haih zyxine, paxillin aur pinch. unamen seey pratyek mein kramshah 3,4 aur 5 key saath alag-alag sankhya mein limm domen hain. inhen asanjan pattikaon seey sambandhit anukoolak protein maanaa jaataa haye joe koshika key aakar koo niyantrit karate hain aur vishisht limm-madhyasth protein-protein antahkriyaon key madhyam seey failate hain.
protein-protein antahkriya.
lima-aich. dee. aur ell. aim. oh..
yeye protein lima domen binding parivaaron kii paraspar kriya key madhyam seey banate hain joe lima 1 seey bandhe hotey hain. lima-ldb lima-hd key vibhinn heterodymer banaane key liye paraspar kriya kartaa haye. yeh aam taur parr ack limm-lidd kshetra banaayega joe limm protein key saath baatchit kartaa haye. limm-aich. dee. koo vikas key dauran motor neurons key liye alag pehchaan nirdhaarit karane key liye jaanaa jaataa haye. yeh ell. aim. oh. 1, ell. aim. oh. 2, ell. aich. aiks. 1, aaee. aiss. ell. 1 aur aim. ee. see. 3 koo baandhata paaya gayaa haye. ell. aim. oh. 2 naabhik mein sthaaniyakrit paaya gayaa haye, joe vishesh roop seey bhroon yakrit mein erythroid vikas mein shamil haye.
zyxine.
yeh protein shuttle key madhyam seey koshika dravya aur naabhik key beach sthaaniyakrit hotaa haye. yeh koshika asanjan sthalon aur naabhik key beach jaane parr kendrit haye. lima domen kii jastaa ungaliyaan swatantra roop seey kaary karengi. zyxine mein vibhinn prakaar key bandhan bhagidar hotey hain jaise kii crop, α-aiktinin, proto-oncogene vaav, pee130, aur protein key enaa/wasp parivaar key sadasya. zyxine kii gyaat antahkriya enaa/wasp aur see. aar. pee. 1 key beach hoti haye. see. aar. pee. 1 kii pehchaan key liye limm1 jimmedaar haye, lekin zyxine koo baandhane key liye limm2 key saath sahyog kartaa haye. enaa/wasp profilin koo baandh dega joe ack actin-polymerising protein key roop mein kaary karane key liye jaanaa jaataa haye. zyxine-wasp complexes cytoskeletal sanrachana key liye actin-polymerisation shuru karega.
paxillin.
yeh protein fokal asanjan sthalon parr koshika dravya mein sthaaniyakrit hotaa haye. yeh vasaayukt aml aur systoskeletal sanrachana key vikas key liye ack kendriya protein key roop mein kaary kartaa haye. fatty acid mein, way kaee badhyakari bhagidaron key liye machaan key roop mein kaary karate hain. see-terminal parr limm domen protein tyrosine phosphat-keat koo baandhata haye. pee. tii. pee.-keat see-termini lima 3 aur 4 parr fatty acid koo alag karane key liye baandhata haye joe fatty acid lakshit kshetron key modulan kaa kaaran banega. bandhan kii seema limm 2 aur 4 parr nirbhar karegi. yeh pee130 aur paxillin key defosphorylation parr hoga.
goodhata.
yeh protein koshika dravya mein sthaaniyakrit haye, joe sanket aur protein taskari mein kaary kartaa haye. iss protein kii sanrachana mein see-terminal parr teen lima domen hotey hain. yeh limm domen 3 parr insulin receptor aantarikakaran rupankan (insurf) koo baandh dega. limm domen 2 raits receptor tyrosine kinnez koo baandhata haye.
chutaki lein.
yeh protein koshika dravya aur naabhik mein sthaaniyakrit hotaa haye. yeh sparsh receptor neurons key vishisht maanspeshiyon key paalan karane vaale junctions aur yantrikikaran karyon koo prabhaavit karane key liye jimmedaar haye. limm domen mein protein anukram bahut chhote interdoman peptides aur see-terminal extension key saath uchch matra mein sakaratmak aaveshon key saath judey hue hain. protein key kaee kaary hotey hain joe senacent erythrocyte antigen mein bhee prastut hotey hain. yeh integreen-linked kinnez key enkirin repeat domen seey juda sakata haye. isake alawa, chimti kaa lima domen 4 ack anukoolak key roop mein kaary karane key liye aine. key. 2 protein seey juda sakata haye.

