
resf1

retrolement silencing factor 1 ack protein haye joe manushyon mein resf1 jeane dwara encode kiya jaataa haye. resf1 vyaapak roop seey lymph nodes, andashay, appendix aur pliha mein vyakt kiya jaataa haye. resf1 ack mamuli histocompatibility antigen honey kii visheshtaon key saath-saath tumour suppressor kshamataon koo bhee darshaata haye. lymph nodes aur pliha mein uchch abhivyakti pratiraksha pranali mein kaary kaa sanket detee haye.
jeane.
resf1 gunasutra 12 parr paaya jaane vaalaa ack protein coding jeane haye aur 12p11.21 key liye maanchitra haye. iss jeane key liye vaikalpik naamon mein gonad vyakt pratilekh (praapt), yuu. tii. aeye. 2-1 aur see. 12oh. aff. 35 shamil hain. resf1 mein 7 exon hain, jinamen seey 3 coden shuru honey seey pahale hotey hain.
ootak abhivyakti.
samanya.
samanya maanav ootak abhivyakti profiling key ack adhyayan seey pataa chalata haye kii resf1 atyadhik roop seey thymus, pliha, asthi majja aur yakrit mein vyakt kiya jaataa haye. yeh dilchasp haye kyonki yeh pratiraksha pranali seey judey samanya angon seey sambandhit haye.
rashtriya jaiv praudyogiki soochana kendra key madhyam seey paae gaye jeane ootak abhivyakti pattern unigene est profile seey pataa chalaa kii lymph nodes, garbhashay, munh, thyroid, swaryantra aur rakt mein bhee resf1 kii uchch abhivyakti thee.
cancer.
swaasthya sthitiyon mein resf1 abhivyakti kaa mulyankan aine. see. bee. aaee. unigene key est profile kaa upayog karke kiya gayaa thaa. halanki resf1 garbhashay tumour mein atyadhik vyakt kiya jaataa haye, yeh garbhashay mein bhee atyadhik vyakt kiya jaataa haye, yeh sujhaav dete hue kii yeh jeane garbhashay cancer key saath nikatata seey judaa huaa haye, isaki sambhavana naheen haye. haalaanki, resf1 adhivrikk tumour seey sambandhit hoe sakata haye, kyonki samanya gurde key ootak key bheetar iss jeane kii abhivyakti cumm thee.
pratilekh.
pratilekhan kaarak badhyakari sthal.
resf1 key pravartak key bheetar pratilekhan kaarak bandhan sthalon mein mukhya roop seey pratilekhan kaarak shamil they joe asthi majja koshikaon, antibody-utpaadak koshikaon aur rakt koshikaon seey judey they. yeh kaaryasheel pratiraksha pranali key saath resf1 key sambandh kaa samarthan kartaa haye.
protein.
resf1 lambai mein 1747 amino acid haye aur agyaat kaary kaa ack kshetra haye, duff4617. resf1 kaa aanvik vajan 194.9 cadel haye. besal isoelectric bindu 8.95 haye. ack sthaaniyakaran bhavishyavani seey pataa chalata haye kii resf1 sambhavatah ack paramanu protein haye.
protein sanrachana.
resf1 kii dwiteeyak sanrachana mein mukhya roop seey yaadrichhik kundal sanrachanaaen (lagbhag 59.2%), kuchh alfa helix (avasheshon kaa 24 pratishat) aur cumm vistaarit strand (avasheshon kaa 15.8%) hotey hain.
oopar dikhaae gaye swiss model kaary sthaan kaa upayog karke ack anumaanit 3-dee sanrachana banaai gaee thee.
protein antahkriya.
resf1, nainog, aim. dee. aim. 2, exoc 1 aur shaant 3 key saath antahkriya kartaa haye. yeye antahkriyaaen aage sujhaav detee hain kii resf1 ack paramanu protein haye, aur yeh tumour-suppressor protein aur pratiraksha pranali protein key saath judaa hoe sakata haye.
exoc1 ack schizophrenia adhyayan mein shamil thaa, joe ack schizophrenia jokhim jeane (disk1) koo protein-protein antahkriyaon key ack network seey sambandhit thaa. iss adhyayan mein dou-sankar parakh kaa upayog resf1 aur exoc1 key beach protein kii paraspar kriya key pramaan key roop mein kiya gayaa. exoc1 sookshmajeev sankramanon kii pratikriya key roop mein kaary kartaa haye, joe viral aar. aine. aeye. sanshleshan aur protein anuvaad koo cumm kartaa haye.
nainog key ack aatmiyata grahan-aim. aiss. key aadhar parr resf1 key saath baatchit karane kii bhavishyavani kii gaee thee, joe nainog koo koshika chakr seey judey protein seey jodata haye. iss adhyayan mein vishisht protein antahkriyaon koo khojane key liye uchch sateekta vaale dravyamaan spectrometry key saath sanyukt aatmiyata shodhan kaa upayog kiya gayaa. nainog koo bhroon stame koshikaon mein ack aavashyak pratilekhan kaarak bhee paaya gayaa thaa, vishesh roop seey koshika bhaagya koo prabhaavit karane key liye jeane abhivyakti mein shamil thaa.
aim. dee. aim. 2 ack aisaa jeane haye joe koshika chakr aur apoptosis koo prabhaavit karane key liye dusaron key saath baatchit kartaa haye, aur resf1 key liye samanya ootakon mein sthit haye, jaise kii garbhashay aur lymph node. aim. dee. aim. 2 koo phase display library key upayog key madhyam seey resf1 key saath baatchit karate hue paaya gayaa. iss antahkriya seey aage pataa chalata haye kii resf1 ack paramanu protein haye, kyonki aim. dee. aim. 2 aur isake splies roopon mein nucleoplasmic vitaran key liye paramanu sthaaniyakaran sanket hotey hain.
shaant 3 koo sambandh pakadane-aim. aiss. parakh key aadhar parr resf1 key saath baatchit karane key liye paaya gayaa thaa, jaisa kii nainog koo resf1 key saath baatchit karane key liye paaya gayaa thaa. epidermal vikas mein shaant 3 abhivyakti parr ack adhyayan seey pataa chalaa kii shaant 3 vikas key liye upayogi marker thaa, aur shaant 3 abhivyakti kaa nuksan ghaatak phenotype key saath sahsambaddh thaa.
vikaasvaadi sambandh.
orthologue.
resf1 key sabse nikatatam orthologue primate hain, haalaanki, sanrakshit anukram whale, bhalu, saamp, pakshi, kachhue aur mendhakon mein paae jaa sakate hain. resf1 key orthologue bahut pahale 35.3 karod saal pahale ("zenopus levis") alag hoe gaye they, jabaki nikatatam vikaasvaadi orthologue "papio anubis" haye, joe lagbhag 28.1 karod saal pahale alag hoe gayaa thaa.
phylogenetic vriksh.
resf1 kaa ack jadaheen phylogenetic vriksh 20 orthologue aur maanav resf1 jeane seey banaaya gayaa thaa.
aanvik phylogeny.
resf1 key aanvik vikas key neeche dikhaae gaye ack graph seey pataa chalata haye kii yeh cytochrome see, ack dheere-dheere vikasit honey vaale protein aur fibrinogen alfa, donon kii tulanaa mein apekshaakrit teji seey vikasit huaa, joe cytochrome see kii tulanaa mein adhik teji seey vikasit huaa. tulanaa seey pataa chalata haye kii resf1 kaafee jaldi alag hoe rhaa haye, joe bataata haye kii yeh ack aisaa jeane hoe sakata haye joe apane paryaavaran kii pratikriya mein jaldi seey badal jaataa haye, jaise kii ack rogjanak kaa parichay. 

