
jeffery doubleu. kellie

jeffery doubleu. kellie (janm 23 agast, 1960 madina, newyork mein) ack americi vyavasaayi aur rasaayanagya hain joe laa jolaa, california mein scrips anusandhaan sansthaan key sankaay mein hain.
jeevani.
kellie koo apana ph milaa.dee. chappel hill (1986) mein north carolina vishvavidyalaya seey javic rasayan vigyaan mein aur rockfeller vishvavidyalaya (1986-89) mein post-doctoral shodh kiya.
way snaatak adhyayan key poorv deane (2000-2008) aur shaikshanik mamalon key upaadhyaksh (2000-2006) aur aanvik chikitsa key saha-adhyaksh aur laa jolaa, california mein scrips anusandhaan sansthaan mein rasayanik jeev vigyaan key scags sansthaan key bheetar rasayan vigyaan key leeta ennenberg hazen professor hain. unakaa shodh protein folding, galat folding aur ektrikaran koo samajhane aur protein galat folding aur/yaa ektrikaran key kaaran honey vaali beemariyon koo cumm karane key liye rasayanik aur javic donon ranneetiyon koo vikasit karane parr kendrit haye.
kellie ney teen jaiv praudyogiki companiyon kii saha-sthaapana kii haye, 2003 mein susain lindqvist key saath folderks pharmaceuticals, proteostasis therapeutics, ink. 2010 mein andreau dillin aur richard morimoto key saath, aur 2012 mein galat nidan.
unaki prayogshala ney 1990 key dashak mein transthiratine fibrill gathan koo rokane key tarikon kii talash shuru kii. tafamidis kii khoj antatah kellie kii team dwara ack sanrachana-adharit dawa design ranneeti kaa upayog karke kii gaee thee; sanrachana pahali baar 2003 mein prakaashit hui thee. 2003 mein kellie ney mitt key susan lindqvist key saath folderks kii saha-sthaapana kii aur whitehead sansthaan aur folderks ney 2010 kii shuruat mein europe mein vipanan anumodan key liye ack aavedan jamaa karke tafamidis vikasit kiya. usa varsh key anta mein folderks koo pfizer dwara adhigrahit kiya gayaa thaa.
sammaan aur puraskar.
1991-searl scholar puraskar
1999-jaivbhautikiya samaaj rashtriya vyakhyata (puraskar)
1999-protein society-dupont yuva anveshak puraskar
2000-friedonia key poorv chhatron koo vishisht upalabdhi puraskar
2001-american chemical society arther see. vidwan puraskar kaa saamana karein
2006-rashtriya swaasthya yogyata sansthaan puraskar
2008-american peptide society vincent doo wigneud puraskar
2011-american peptide society raav mekineni vyakhyan (puraskar)
2011-protein society emil tii. casser puraskar
2012-american chemical society, ralf aff. peptide rasayan vigyaan mein hirshman puraskar
2012-biopolymer murre goodman smaarak puraskar
2016-royal society off chemistry jeremi nolls puraskar
2016-jaiv praudyogiki aur chikitsa mein jacob hescale gabbe puraskar
2016-sunn fredonia mein praarambhik sambodhan.
2016-american academy off arts aind sciences key sadasya 
2017-american institute off chemists kaa rasayanik agrani puraskar
2017-rasayan vigyaan key shaahi samaaj key sadasya
2017-aavishkarakon kii rashtriya akadami key sadasya
2022-jeevan vigyaan mein safalata puraskar
2023-rasayan vigyaan mein bhediya puraskar.
mahatvapurna kagjat.
1992 collan, doubleu.; kellie, jey.doubleu. "transthyratine kaa aanshik vikriteekaran inn vitro mein amyloid fibrill gathan key liye paryaapt haye."jaiv rasayan, 31 8654-8660.
2001 jegger, aim.; guyen, aich.; crain, jey.see.; kellie, jey.doubleu.; gruebelle, aim. "ack β-patrak kaa taha tantrah doubluedblue domen" jey. moll. bayol., 311,373-393.
2001 hammerstrom, pee.; sneeder, aff.; kellie, jey.doubleu. "ack amyloid roga mein galat tareeke seey modane kaa trance-daman" vigyaan 293,2459-2461.
2002 socker, aeye.aar.; cheng, doubleu-see.; beautler, ee.: wong, see.- hah.: balch, doubleu.ee.: kellie, jey.doubleu. "rasayanik chepron aine370aiss beeta-glucosidase kii koshikiya gatividhi koo badhaate hainh gauchar roga key liye ack chikitsiya ranneeti" proke. nuttle. akaadamik. vigyaan. 99, 15428-15433.
2003 hammerstrom, pee.; buddhiman, aar. ell.; shaktiyaan, ee.tii.; kellie, jey.doubleu. "protein koo galat tareeke seey modane vaale oorjaa koo badalkar transthyratine amyloid roga kii roktham" vigyaan 299,713-716.
2004 dechongkit, aiss.; guyen, aich.; dosson, pee.ee.; gruebelle, aim.; kellie, jey.doubleu. reedh kii huddy key aich-bandhan key sandarbh parr nirbhar yogdan β-sheet folding oorjaa" prakriti 430,101-105.
2005 sekijima, vaaee., buddhiman, aar.ell., matson, jey., hummarstrom, pee., miller, aiss.aar., balch, doubleu.ee., kellie, jey.doubleu. ootak chayanaatmak amyloid roga key liye javic aur rasayanik aadhar" koshika 121,73-85.
2006 faller, dee.aim.; kaulov, aeye.vee.; alori-jost, see.; nishan, aim.aiss.; balch, doubleu.ee; kellie, jey.doubleu. "standhari ootak key bheetar karyatmak amyloid gathan" ploss jeev vigyaan 4,100-107.
2008 myu, tii-doubleu.; ong, dee.aiss.tii.; wang, vaaee-jey; balch, doubleu. ee.; yates, jey.aar.; segatori, ell.; kellie, jey.doubleu. .rasayanik aur javic drishtikon protein-folding rogon koo behtar banaane key liye talmel banaate hain" koshika 134,769-781.
2008 balch, doubleu.ee.; morimoto, aar.aaee.; dillin, aeye.; kellie, jey.doubleu. roga hastakshep key liye proteostasis koo anukoolit karna" vigyaan 319,916-919.
2010 villie; ack kaar durghatana mein mrityu hoe gaee
2011 culiba, ee.key.; keemat, jey.ell.; hanson, aiss.aar.; dhaar, aeye,; wong, see-aich.; gruebelle, aim.; shaktiyaan, ee.tii.; kellie, jey.doubleu. aine-glycosylated riverse turn mein sugandhit side chain koo rakhkar protein mool sthiti sthirikaran" vigyaan 331,571-575.
2012 bulawa, see.ee.; connelly, aiss.; devit, aim.; wang, ell. weigel, see.; flimming, jey. packman, jey.; shaktiyaan, ee.tii.; buddhiman, aar.ell.; phos, tii.aar.willson, aaee.aeye.; kellie, jey.doubleu.; laboudineer, aar. tafamidis, ack shaktishali aur chayanaatmak transthiratine gatij sthirikaran joe amyloid cascade" "proke koo rokta haye. nuttle. akaadamik. vigyaan. 109, 9629-9634.
2013 chain, doubleu; enak, aiss.; keemat, jey.ell.; shaktiyaan, dee.ell.; shaktiyaan, ee.tii.; wong, see-aich.; dyson, aich.jey.; kellie, jey.doubleu. protein-carbohydrate antahkriyaon kaa sanrachanaatmak aur urjaavaan aadhar" jey. main. came. sou. 135, 9877-9884.

