
kaunis syndrome

kaunis syndrome koo acute coronary syndrome (hriday mein cumm rakt pravaah seey sambandhit chhaati mein dard jaise lakshan) key roop mein paribhaashit kiya gayaa haye joe ack allergy pratikriya yaa ack dawa yaa anya padaarth key liye ack majboot pratiraksha pratikriya key kaaran hotaa haye. yeh ack durlabh syndrome haye jisamen 130 purushon aur 45 mahilaaon mein pramanik mamle darj kiye gaye hain, jaisa kii 2017 mein sameeksha kii gaee thee; haalaanki, iss vikaar koo aamtaur parr andekha kiye jaane kaa sandeh haye aur isaliye yeh adhik prachalit haye. stun koshika sakriyan aur soojan cytokins key saath-saath pratikriya seey anya soojan agents kii rihaai seey dhamniyon mein ainthan hoti haye jisase hriday kii maanspeshiyaan yaa ack pattika tootati haye aur una dhamniyon mein seey ack yaa adhik koo avaruddh karati haye.
kaunis syndrome coronary dhamani ainthan aur lakshnon key dou anya karanon seey alag haye.kaheen adhik samanya, gair-allergy syndrome, pringematals angina aur eosynophilic coronary periorteritis, ack behad durlabh vikaar joe adventicia aur periadventicia key vyaapak eosynophilic ghuspaith key kaaran hotaa haye.ee. komal ootak, coronary dhamniyon key aspas.
mahamari vigyaan.
vibhinn mamalon key avalokan key madhyam seey, kaunis syndrome kaee alag-alag naslon aur bhaugolik kshetron mein dekhaa gayaa thaa. haalaanki, turkey, grees, itali aur spen sahit adhikansh mamle dakshini europe mein paae gaye hain. baal roga rogiyon seey laker bujurgon taka kii ack vistrit ayu seema dekhi jaati haye, jisamen 2 seey 90 varsh kii ayu taka kii ayu shamil haye. aamtaur parr dekhi jaane vaali anya beemariyon mein hyperlipidemia, madhumeh, dhumrapan, uchch raktchaap aur ack avakshepak kaarak key liye poorv allergy pratikriyaen shamil hain. sateek prasaar koo nirdhaarit karna mushkil haye kyonki yeh nidan chook gayaa haye yaa cumm nidan kiya gayaa haye. jeane-paryaavaran antahkriya kii sambhavana haye kyonki ack adhyayan mein bataaya gayaa haye kii aapaatkaaleen vibhaag key mulyankan key baad bharti kiye gaye sabhi rogiyon mein vishamyugma ee148kyu utparivartan thaa.
ateology.
iss syndrome koo cumm karane key kaee karanon kii khoj kii gaee haye, jisamen davaaen, vibhinn swaasthya sthitiyaan, bhojan aur paryavaraniya jokhim shamil hain. inmein seey koee bhee avakshepak kaarak joe aaee. jee. ee. antibody utpaadan kaa kaaran banata haye, iss syndrome mein yogdan curr sakata haye. pahale paaee gaee davaaon mein aspirin aur diapron, anaesthetics, kaee antibiotic, heprin aur lepirudine jaise anticoagulants, thrombolytics jaise tii. pee. aeye., anty-platelet therapy jisamen clopidograil, anty-neoplastics, glucocorticoids, nonsteroid anty-inflammatory drugs, proton pump inhibitors aur twacha kitanunashak shamil hain. isake alawa, sahaanubhooti, matra vistaarak, antifungal, antiviral aur maukhik garbhanirodhak bhee iss syndrome koo trigger curr sakate hain. anya vishisht samanya davaaon mein allopurinol, analypril, losarton, insulin aur kaee anya shamil hain. incriminate kaunis syndrome kii sthitiyon mein bronchial asthama, churg-strass syndrome, seeram sickness, scombroid syndrome, angioadema, haye fever, anaphylaxis (vyayam prerit yaa idiopathic), aur anisakiasis shamil hain. coronary stenting, coronary dhamani roga key rogiyon mein upayog kii jaane vaali ack samanya prakriya bhee ack kaaran paaee gaee haye. vish iv, ghaas, latex aur nicotine key paryavaraniya sampark mein aaney seey yeh sahayak paaya gayaa haye. kaunis syndrome koo utpann karane vaale jeevon key kaatane mein makadiyan, saamp, bichchu, aag kii cheentiyaan aur jelifish shamil hain. vividh triggers mein contrast media shamil haye. vibhinn khaadya padarthon key prati pratikriya joe allergy aur soojan pratikriya kaa kaaran banati haye, teevra coronary syndrome kaa kaaran bunn sakati haye.
sanket aur lakshan.
allergiek essie ack syndrome haye jisamen dou ghatak shamil hotey hain. ack ghatak pratiraksha madhyasthata haye jisake parinamswarup atisamvedansheelta, allergy aur anaphylactic yaa anaphylactoid pratikriya hoti haye. dusare ghatak mein teevra coronary syndrome (assie) key saath dekhe jaane vaale hriday sanket aur lakshan shamil hain. hriday sambandhi lakshan rogi dwara prastut kiye gaye prakaar key prakaar key aadhar parr bhinn hotey hain. teevra coronary syndrome aamtaur parr chhaati mein ack sankochak dard seey judaa hotaa haye, joe gardan yaa baain baanh mein vikiran key saath hotaa haye aur aksar peelapan, pasina, matali aur saans lene mein takleef seey judaa hotaa haye. pariksha mein hriday sambandhi sanketon mein sardi, bradycardia, tachycardia, hypotension, sambhaavit cardiorespiratory arrest yaa achaanak mrityu bhee shamil hain. jiss tarah ack allergy pratikriya mein ack halki aur sthaaniya pratikriya seey laker vyaapak aur jeevan key liye khatarnak kuchh hoe sakati haye, usee tarah allergy vaale assis kaa allergy ghatak bhee usee tarah seey prastut kartaa haye. allergy vaale assis mein antarnihit allergy pratikriya seey sambandhit vishisht lakshan bhee hoe sakate hain, jaise kii chehare aur jeebh kii soojan, ghargharahat, pitti aur sambhaavit roop seey bahut cumm raktchaap (anaphylactic shock). atirikt nishkarshon mein stridor, unindapan, syncope, pett dard, dast, ulti aur gambhir honey parr teevra fuffusiya shoth shamil hoe sakate hain.
myocardial inforction, teevra hriday viphalata aur achaanak hriday mrityu bhee dekhi jaa sakati haye. vayaskon kii achaanak hriday sambandhi mauton key 13 pratishat key roop mein adhik maast cell degrenulation key saath jodaa jaataa haye joe nishkarsh nikaalata haye kii kaunis syndrome mein ack mook allergy pratikriya shamil hoe sakati haye.
pathophysiology.
allergy mein, maast koshikaaen histamine, neutral protease, arachidonic acid derivatives, platelet activating factor aur vibhinn prakaar key cytokine aur chemochine jaise soojan vaale padaarth chhodati hain. yeye madhyasth coronary dhamani kii ainthan koo tej curr sakate hain aur coronary dhamniyon key atheromatous plake key tootane mein teji laa sakate hain. yeh hriday kii maanspeshiyon mein rakt pravaah mein hastakshep kartaa haye aur lakshnon kaa kaaran banata haye anyatha asthir enzyna seey aprabhedya hotaa haye.
yeh sambhav haye kii allergy key pratyaksh pramaan key binaa bhee logon mein, allergy pratikriya teevra coronary syndrome mein ack bhoomika nibha sakati haih maast cell sakriyan key marker assie vaale logon mein paae jaate hain.
nidan.
kaunis syndrome aksar chhoot jaataa haye yaa cumm nidan kiya jaataa haye isaliye roga prakriya aur naidaanik prastuti koo samajhana jabaki samasya key liye ack uchch sandeh honah anivarya haye.  trigger exposure aur lakshnon kii shuruat key beach kii avadhi parr dhyaan kendrit karna mahatvapurna haye. adhikansh mamalon kii avadhi ack ghante seey cumm thee jabaki kuchh kii avadhi 6 ghante thee. yadi myocardial ischemia yaa inforction kaa sandeh maujood haye tou ee. key. jee., chhaati kaa aiks-ray, echocardiography aur angiography kii aavashyakta hoti haye.
naidaanik, electrocardiographic, angiographic, echocardiographic aur teevra myocardial ischemia key prayogshala nishkarshon seey judee pranaaleegat allergy pratikriyaon vaale rogiyon koo kaunis syndrome honey key roop mein nidan kiya jaanaa chaahiye. ee. key. jee. parivartan aamtaur parr nimn star key seese, ischemia, sinus bradycardia yaa tachycardia, hriday avrodh, alind compan, nilay compan, nilay apasthaaniya taal, kyu. aar. aiss. aur kyu. tii. deerghaavadhi mein aur diagoxin vishaaktata key samaan nishkarshon mein inforction key saath susangat hoe sakate hain. echocardiography atherosclerotic stenosis aur thrombosis koo khojane mein sahaayata karati haye.
seeram tryptase, histamine, immunoglobulin (aaee. jee. ee.), cardiac enzyme, cardiac troponin nidan kii pushti karane mein sahayak hotey hain. kaunis syndrome mein, naee takneekon jaise kii thallium-201 ekal-photon utsarjan computer tomography (spect) aur 125i-15-(pee-iodophenyl)-3-(r, s) methylpentadecanic acid (bmipp) spect ney gambhir myocardial ischemia kaa khulasa kiya haye, jabaki coronary angiography ney samanya coronary dhamniyon koo dikhaaya haye. isake alawa, cardiac magnetic resonance imaging (aim. aar. aaee.) key saath, vilambit contrast-vardhit chhaviyaan kaunis syndrome prakaar aaee sanskaran key rogiyon mein subendocardial ghaav kshetra mein samanya dhone koo darshaati hain.
anya samaan prastutiyon mein takotsubo aur atisamvedansheelta myocarditis shamil hain.
vargeekaran.
kaunis syndrome key teen roopon koo pahachaana jaataa haih
prabandhan.
inn rogiyon kaa prabandhan chikitsakon key liye chunautipurna hoe sakata haye. haalaanki beeta blocker assie mein fayademand hoe sakate hain, way kaunis syndrome mein pratikool hain. allergy vaale essie mein, epinephrine dete samay beeta receptors koo avaruddh karna (joe anaphylaxis key upchaar kaa aadhar haye) α-adrenergic receptors kii ack nirvirodh gatividhi kaa kaaran bunn sakata haye joe coronary ainthan koo badhaa dega. opioid bhee, joe chhaati key dard seey raahat dene key liye sanketit haye, badey paimaane parr maast cell degrenulation koo prerit curr sakata haye joe badale mein anaphylaxis koo kharaab curr dega. isaliye aise rogiyon koo saavdhaanipoorvak diyaa jaanaa chaahiye.
type aaee sanskaran.
type I sanskaran kaa ilaaj isaki naidaanik prastuti aur allergy pratikriya kitni gambhir haye, isake aadhar parr kiya jaataa haye. yadi yeh ack halki pratikriya haye, tou antihistamine aur corticosteroids lakshnon koo niyantrit karane mein madad curr sakate hain. yadi rogi kii prastuti mein anaphylaxis shamil haye, tou intramscular adrenaline diyaa jaanaa chaahiye.
allergy kii ghatana kaa upchaar akele prakaar I sanskaran koo samaapt curr sakata haye. nitroglycerine yaa calcium channel blocker jaise vasodilator dene kii sifarish kii jaati haye. isake parinamon mein hypotension aur anaphylaxis kaa bigadana shamil haye. antihistamine aur maast cell stabilizer ee.jee. chromoglicate yaa nedochromil parr bhee vichaar kiya jaa sakata haye.
prakaar II sanskaran.
teevra coronary ghatana protocol lagu kiya jaataa haye aur prakaar II kaa ilaaj hriday lakshan niyantran key liye prakaar I key samaan kiya jaa sakata haye. chronic beeta-blocker key poorv upayog vaale rogiyon mein teevra anaphylaxis key liye adrenaline kii tulanaa mein glucagon ack behtar vikalp hoe sakata haye. isake alawa, beeta-blocker coronary vasospasm aur ischemia koo badhaa sakate hain. opiate kaa upayog savdhani key saath kiya jaanaa chaahiye.
prakaar III sanskaran.
teevra coronary syndrome protocol key anuprayog key alawa, thrombus aspiration aur ack nayaa stent rakhane kii aavashyakta hoti haye. steroid aur antihistamine key saath maast cell stabilizer key upayog kii sifarish kii jaati haye. aspirated samagri kii ootakiya jaanch aur eosynophil aur maast koshikaon key liye daag key saath intrastant thrombus kii kataai kii jaani chaahiye. jaba stent pratyaropan key baad allergy key lakshan maujood houn, tou samvedanheenta key upaay lagu kiye jaane chaahiye.
itihas.
jabaki kaee purani reportein hain joe naidaanik roop seey, allergy aur hriday koo morphologic cardiac pratikriyaon, teevra carditis yaa sandhishoth kii buniyaadi visheshtaon key saath ghaavon jaise naamon seey jodati hain, allergy-madhyasth teevra coronary syndrome kaa pahala poorna vivaran greek cardiologist nicolas kaunis koo diyaa jaataa haye, jinhone 1991 mein coronary dhamani ainthan (abb, prakaar I sanskaran) key mamalon mein allergy kii sambhaavit bhoomika parr report kiya thaa. bronwald ney inn ainthanon dwara madhyasthata kii jaane vaali allergy prerit coronary dhamani avrodh koo pahachaana. kaunis syndrome key teen prakaar paae gaye aur ack adhyayan ney nishkarsh nikala kii type 1 sanskaran koo sabse adhik dekhaa gayaa thaa, jisake baad kramshah type 2 aur 3 dekhaa gayaa thaa.

