
curr jeane utpaad

ack curr jeane utpaad (curr) ack paramanu protein haye jiska aanvik vajan lagbhag 37,000 seey 40,000 dalton haye.
curr jeane.
curr retroviral parivaar key primate tii-lymphotropic virus key sadasyon dwara utpaadit kiya jaataa haye, jinhen delteratrovirus key roop mein vargeekrit kiya jaataa haye. isamen maanav tii-lymphotrophic virus (aich. tii. ell. vee. aiss.), bowine leukemia virus (bee. ell. vee.) aur simean tii-lymphotropic virus (aiss. tii. ell. vee. aiss.) shamil hain. aich. tii. ell. vee.-1 aur aich. tii. ell. vee.-2 seey utpaadit curr protein kaa sabse vyaapak roop seey adhyayan kiya gayaa haye. curr key liye jeane "nv" jeane aur viral genome key lambe antim punaraavrittiyon mein seey ack key beach px kshetra key bheetar paaya jaataa haye; jahan naam curr aataa haye (aiks-jeane kshetra seey transactivator). curr ack transactivator key roop mein kaary kartaa haye, jisase lambe terminal repeat mein viral protein kaa pratilekhan (aanuvanshik code seey aim. aar. aine. aeye. kaa utpaadan) hotaa haye joe pratikriti key liye aavashyak hotey hain.
roga mein bhoomika.
aich. tii. ell. vee.-1 leukemia key ack aakramak roop kaa kaaran banata haih vayask tii cell leukemia (aeye. tii. ell.), aur curr koo kaafee hudd taka iss virus kii oncogenic kshamata mein fansaaya gayaa haye. naabhik mein viral protein key pratilekhan koo badhaava dene kii curr kii kshamata key alawa, yeh kaee maanav jeane koo bhee niyantrit kartaa haye. yeh kaee sanket maargon kii gatividhi koo sanshodhit karke aisaa kartaa haye jaise kih crabe/aeye. tii. aff., aine. aff.-key. bee., aeye. pee.-1 aur aiss. aar. aff.. curr protein-protein antahkriya (protein key saath bandhan), pratilekhan sakriyan (protein key utpaadan koo badhaava denaa) aur pratilekhan daman (protein key utpaadan koo rokna) dwara koshikiya prakriyaon koo sanshodhit kartaa haye. koshika prakriyaaen joe cancer koshikaon key utpaadan key liye curr koo viniyamit karati hain, unamen koshika chakr aur genomic akhandata kaa rakharkhaav shamil haye. koshika chakr key chaar charan (jee1, aiss, jee2 aur aim) hotey hain aur curr koo jee1 aur aiss charan key beach sankraman mein teji laane key liye jaanaa jaataa haye. dou dee. aine. aeye. marammat maarg (aadhar chhedan marammat aur nucleotide chhedan marammat) curr seey prabhaavit hotey hain, jisase dee. aine. aeye. mein utparivartan hotaa haye; joe cancer kii ack shaastriya pehchaan haye. curr bhee acuploidae (asamanya gunasutra sankhya) kaa kaaran banata haye, joe parivartan (samanya koshikaaen cancer koshikaaen banane) kaa ack sambhaavit kaaran haye. inn prakriyaon mein kaee protein shamil hain, jinamen cycline aur koshika chakr jaanch bindu protein (pee53 aur rb) shamil hain. dilchasp baat yeh haye kii aich. tii. ell. vee.-1 curr viral jeane koo aiss. oh. see. aiss. 1 aur areal hydrocarbon receptor interacting protein (aeye. aaee. pee.) key madhyam seey mezban kaa pataa lagaane aur unmoolan seey bachane key liye janmajaat antiviral signalling maargon koo cumm karane key liye jaanaa jaataa haye.
halanki aich. tii. ell. vee.-1 aur aich. tii. ell. vee.-2 seey curr koshikaon koo prayogaatmak roop seey cancer kaa kaaran bunn sakata haye, aich. tii. ell. vee.-2 dwara utpaadit curr aich. tii. ell. vee.-1 kii tulanaa mein cumm oncogenic haye aur isaliye ise kaaran maanaa jaataa haye kii aich. tii. ell. vee.-2 aeye. tii. ell. seey judaa naheen haye.

