
weeland-misher keaton

weeland-misher keaton ack resemic cyclic dicatone (inedione) haye aur ack bahumukhi synthon haye jise abb taka 50 seey adhik praakritik utpaadon, mukhya roop seey sesquiterpanoids, dieterpean aur steroid key kull sanshleshan mein niyojit kiya gayaa haye, jisamen cancer rodhi, roganurodhi, antiviral, antineurodegenerative aur immunomodulatory gatividhiyon sahit sambhaavit javic guna hain. abhikarmak kaa naam siba geegi, carle misher aur peater weeland (heinrich otto weeland key saath bhramit naheen honah chaahiye) key dou rasaayanagyon key naam parr rakhaa gayaa haye. praarambhik samagri key roop mein iss dicatone key optical roop seey sakriya anantiomer kaa upayog karke kiye gaye sanshleshan key udaaharan hain ansistrophuran aur danishefsky kull vargeekaran.
weeland-misher keaton seey shuru honey vaali kull sanshleshan vidhiyon mein adhikansh pragati garbhanirodhak aur anya aushadhiya roop seey praasangik steroid key audyogik sanshleshan key liye vaikalpik tarikon kii khoj seey prerit thee, joe shodh kaa ack kshetra thaa joe 1960 aur 1970 key dashak mein falaa-phoola. weeland-misher keaton mein steroid kii abby-ring sanrachana hoti haye aur iss kaaran seey yeh steroid kankal key liye ack aakarshak praarambhik samagri haye, joe adrenosterone key ack sanshleshan mein upayog kiya jaane vaalaa ack drishtikon haye.
mool weeland-misher keaton resmick haye aur 2-methyl-1,3-cyclohexanadione aur methyl vinail keaton key robbinson annulation mein taiyar kiya jaataa haye. madhyavarti sharaab alag naheen haye. ack anaentioselective sanshleshan ack organocatalist key roop mein ell-prolin koo niyojit kartaa haih
iss pratikriya kii soochana 1971 mein jaid dwara dee gaee thee. jee. hajos aur dee. aar. parrish. unake patent mein, uparokt chitrit prakaashik roop seey sakriya madhyavarti cyclic kettol (koshthak mein) key algaav aur lakshan varnan kaa bhee varnan kiya gayaa haye, kyonki way nirjal dimethylformide (dmf) vilaayak mein pariveshi tapman parr kaam karate they. dee. aim. aiss. oh. vilaayak mein kaam karane seey cyclic kettol madhyavarti koo alag karane kii anumati naheen milati haye, yeh seedhe prakaashik roop seey sakriya cyclic dione kii or leey jaataa haye. iss pratikriya koo hajos-parrish pratikriya yaa hajos-parrish-adder-soyer-witchert pratikriya kahaa jaataa haye.
yeh pratikriya ack-bartan prakriya mein bhee kii gaee haye, jisase 49 pratishat upaj aur 76 pratishat anentiomeric atirikt (ee. ee.) hotaa haih
anya proline-adharit utprerak kii jaanch kii gaee haye.

