
gosipol

gosipol () ack praakritik phenol haye joe kapas key paudhe (genus "gosipium") seey praapt hotaa haye. gosipol ack phenolic aldehyde haye joe koshikaon mein pravesh kartaa haye aur kaee nirjalikaran enzymon key liye ack avarodhak key roop mein kaary kartaa haye. yeh ack peela rung haye. sanrachana atropisomerism koo pradarshit karati haye, jisamen dou anantiomers key alag-alag jaiv rasayanik guna hotey hain.
anya anuprayogon key beach, chean mein iska purush maukhik garbhanirodhak key roop mein pareekshan kiya gayaa haye. apane garbhanirodhak gunon key alawa, gosipol lambe samay seey maleria virodhi gunon key liye bhee jaanaa jaataa haye.
jaiv sanshleshan.
gosipol ack terpanoid aldehyde haye joe isoprenoid maarg key madhyam seey acetate key madhyam seey chayapachaya roop seey banata haye. sesquiterpean diamer gosipol banaane key liye ack mool yugman pratikriya seey gujarta haye. jaiv sanshleshan taba shuru hotaa haye jaba geranil pyrophosphate (jee. pee. pee.) aur isopentinil pyrophosphate (aaee. pee. pee.) koo milakar sesquiterpean agradoot farnacil diphosphate (aff. pee. pee.) banaaya jaataa haye. cadinil catayan (1) koo (+)-δ-cadinine synthes dwara 2 mein aukseekrit kiya jaataa haye. (+)-δ-cadinine (2) okseekaran dwara mool sugandhit sesquiterpean ikai, homogosipol banaane mein shamil haye, joe (+)-δ-cadinine 8-hyroxylase kii madad seey 3 (8-hydroxy-δ-cadinine) utpann kartaa haye. yaugik 3 vibhinn oxidative prakriyaon seey gujarkar 4 (deoxyhemigospol) banaata haye, jise ack electron dwara hemigosipol (5,6,7) mein aukseekrit kiya jaataa haye aur phir ack phenolic oxidative yugman seey gujarta haye, joe phenol samoohon key liye "ortho" hotaa haye, jisase gosipol (8) banata haye. yugman koo hydrogen peroxide-nirbhar peroxidase enzyme dwara utprerit kiya jaataa haye, jisake parinamswarup antim utpaad hotaa haye.
shodh.
garbhanirodhak.
1929 mein jiangxi mein kii gaee ack jaanch mein purushon mein cumm prajanan kshamata aur khaana pakaane key liye kachche kapas key tail key upayog key beach sambandh dikhaaya gayaa. garbhanirodhak prabhaav paida karane vaalaa yaugik gosipol nirdhaarit kiya gayaa thaa.
1970 key dashak mein, cheeni sarkaar ney garbhanirodhak key roop mein gosipol key upayog parr shodh shuru kiya. unaki padhaai mein 10,000 seey adhik vishay shamil they aur ack dashak seey adhik samay taka jaari rahee. unhone nishkarsh nikala kii gossipole ney vishvasaniya garbhanirodhak pradaan kiya, jise maukhik roop seey ack goli key roop mein liya jaa sakata haye, aur purushon key harmon key santulan koo pareshan naheen kiya.
haalaanki, gossipole mein bhee gambhir khaamiyan theen. adhyayanon ney vishayon key beach hypocalemia (cumm rakt potasium star) kii asamanya roop seey uchch darr (0.75%) kii bhee khoj kii. hypocalemia thakan, maanspeshiyon kii kamjori aur isake sabse charam parr, pakshaghat key lakshnon kaa kaaran banata haye. isake alawa, lagbhag 7 pratishat vishayon ney apane paachan tantra parr prabhaav kii soochana dee, lagbhag 12 pratishat ney thakan mein vriddhi kii thee, kuchh vishayon ney napunsakta kaa anubhav kiya thaa yaa kamvasna mein kamee aaee thee, aur 9.9 pratishat aparivartaniya roop seey baanjh hoe gaye they, joe spasht roop seey lambe samay taka upchaar aur gossipole kii adhik kull khuraak seey judey they. adhikansh loga upchaar bund karane aur potasium kii khuraak lene key baad thheek hoe gaye. usee adhyayan seey pataa chalaa kii gosipol upchaar key dauran potasium kii khuraak lene seey primates mein hypocalemia koo rokaa naheen jaa sakaa. potasium kii kamee cheeni aahar yaa aanuvanshik pravritti kaa parinam bhee hoe sakati haye.
1990 key dashak key madhya mein, brazil kii dawa company hebron ney nofertil naamak ack cumm khuraak vaali gossipole goli kaa vipanan karane kii yojana kii ghoshana kii, lekin goli kabhi bhee bajar mein naheen aaee. sthaayi baanjhapan kii asweekarya roop seey uchch darr key kaaran isaki release koo anishchit kaal key liye sthagit curr diyaa gayaa thaa. 5 seey 25 pratishat purush upchaar bund karane key baad ack saal taka azospermic baney rahey. 
shodhkartaon ney sujhaav diyaa haye kii gosipol shalya chikitsa nasbandi kaa ack achchha gair-aakramak vikalp bunn sakata haye.
1986 mein, cheeni saarvajanik swaasthya mantralaya aur rockfeller foundation key sanyojan mein, vishva swaasthya sangathan ney purush garbhanirodhak dawa key roop mein gosipol mein shodh koo bund karane key nirnay koo aupchaarik roop diyaa. anya dushprabhavon key alawa, joe shodhkarta gossipole kii vishaaktata key baare mein chintit theh primates mein garbhanirodhak khuraak kaa 10 gunaa seey cumm hotaa haye, jisase ack chhoti chikitsiya khidki banati haye. iss report ney ack asthaayi garbhanirodhak key roop mein gosipol key aage key adhyayan koo prabhaavi roop seey samaapt curr diyaa, lekin nasbandi key vikalp key roop mein iska upayog karane key liye shodh austriya, brazil, chilly, chean, dominican ganarajya aur nigeria mein jaari haye.
vishaaktata.
khaadya aur pashu krishi udyogon koo vishaaktata seey bachane key liye kapas-vyutpann utpaad key star kaa prabandhan karna chaahiye. udaaharan key liye, kewal jugali karane vaalaa microflora gassipol koo pachaata haye, aur phir kewal ack nishchit star taka, aur kapas key tail koo parishkrit kiya jaanaa chaahiye. aanuvanshik roop seey engineer kapas key paudhon mein beej mein thodaa gosipol hotaa haye, phir bhee tanon aur pattiyon mein yaugik hoe sakata haye.

