
asthesioneroblastoma

asthesioneuroblastom naak guha kaa ack durlabh cancer haye. oopari anunaasik path seey utpann honey vaalaa, asthesioneuroblastom samvedi neuropethalial koshikaon seey utpann hotaa haye, jise neuroactodermal ghraan koshikaon key roop mein bhee jaanaa jaataa haye.
tumour key sthaan aur kapaal guha seey isaki nikatata key kaaran, asthesioneuroblastom atyadhik aakramak aur ilaaj key liye chunautipurna hoe sakata haye. roga kii durlabhata key kaaran asthesioneuroblastom key uchit upchaar drishtikon parr koee aam sahamati naheen haye. adhikansh adhyayanon ney tumour koo lakshit karane key liye radiotherapy yaa chemotherapy key saath kapaal shalya chikitsa kii soochana dee.
sanket aur lakshan.
asthesioneuroblastom aksar pahale naak dravyamaan key roop mein prastut hotaa haye. asthesioneuroblastom key sabse aam sanket aur lakshan naak mein baadha (70 pratishat) aur epistexis (50 pratishat) hain. cumm samanya lakshnon mein hyposmia (gandh kii kamee), sirdard, rhinorrhea, drishti haani, proptosis, chehare kaa dard, diplopia (dohri drishti), gardan mein dravyamaan aur mansik sthiti mein parivartan shamil hain. asthesioneuroblastom oopari naak guha mein, optic tantrikaon aur optic chiyasm key paas hotaa haye. iss prakaar, tumour kaa vikas tantrika kaary koo baadhit curr sakata haye aur isake parinamswarup drishti haani aur dwi-drishti hoe sakati haye. jaise-jaise tumour maukhik guha mein failata haye, daant dard aur daanton kii gatishilata hoe sakati haye.
aanuvanshiki.
asthesioneroblastoma key vikas mein aanuvanshik bhoomika parr seemit shodh haye. aaj taka key shodh mein, sonic hezhog maarg, maisi aur kdr jeane asthesioneuroblastom key liye shamil hain.
dystrophine aur laminine, alfa 2 (laama 2) mein utparivartan bhee iss bimari mein shamil hain.
pathophysiology.
asthesioneuroblastom neurocrest mool kaa haye, joe ghraan upkala mein ghraan samvedi koshikaon seey utpann hotaa haye. ghraan upkala mein ghraan samvedi koshikaaen, sthaayi koshikaaen aur mool koshikaaen hoti hain. asthesioneuroblastom mein neurofibrular fiber aur rosset key saath lobular sheet hoti haye. hime key vargeekaran purvanuman nirdhaarit karane kaa ack mahatvapurna tarika haye.
asthesioneuroblastom key liye hime key hystopathological grade
nidan.
asthesioneuroblastom chhote neele koshika tumour jaise squamous cell carcinoma, sinonsal avakalit carcinoma, extranodal enke/tii cell lymphoma, naak kaa prakaar, rabodomosarcoma, eaving/peanet, mucosal ghaatak melanoma aur neuroendocrine carcinoma (nec) jaisa hoe sakata haye joe intranasal tract mein hotaa haye. iss kshetra mein anya tumours kii tulanaa mein, asthesioneuroblastom mein sabse achchha purvanuman haye, jisamen kull milakar paanch saal kii uttarjeevita darr 60-80% haye. akele sanyukt raajya america mein 700 seey cumm mamle darj kiye gaye hain. asthesioneuroblastom kii visheshta neurofibrillary stroma aur neurosecratory granule hain joe iss kshetra mein kissy bhee anya vikriti dwara samvarti roop seey naheen dekhe jaate hain. keratin, see. key. 5/6, aiss-100 protein yaa aine. aiss. ee. jaise ootakiya parikshanon koo anya tumour seey asthesioneroblastoma koo aur alag karane key liye chalaaya jaa sakata haye.
staging.
kish vargeekaran kaa upayog asthesioneuroblastom sahit sinonsal tumour key naidaanik vargeekaran key liye kiya jaataa haye. tumour grade key aadhar parr purvanuman nirdhaarit karane key liye baad key shodh lekh prakaashit kiye gaye hain.
sanshodhit kish vargeekaran
dulguerov vargeekaran
upchaar.
asthesioneuroblastom key liye pasandida upchaar shalya chikitsa haye jisake baad tumour kii punaravritti koo rokane key liye radiotherapy kii jaati haye.
shalya chikitsa key tareeke.
kaee shalya chikitsa paddhatiyon kaa varnan kiya gayaa haye, lekin vichhedan key baad punaravritti darr apekshaakrit adhik rahee haye. adhyayanon seey ack dwaipaakshik drishtikon key saath behtar parinam kaa sujhaav milata haye. cribriform plate kii bhagidari vaale mamalon key liye, tumour koo ack transfacial aur chraniotomy drishtikon kaa upayog karke dwaipaakshik roop seey alag kiya jaataa haye. ack shodh adhyayan mein, chraniophacial drishtikon ney asthesioneuroblastom kii punaravritti mein 20 pratishat kii kamee kii. chraniophacial vichhedan cribriform plate, ghraan bulb, bulb key aspas key dura aur yahaan taka kii orbital periostium koo hataate hue optic tantrikaon aur mastishk koo sanrakshit karane mein madad curr sakata haye.
radiotherapy.
kewal radiotherapy kewal chhote ghaavon key liye aarakshit haye joe sergery yaa chemotherapy key liye upayukt naheen haye. photon aur proton radiotherapy donon kaa upayog asthesioneuroblastom key ilaaj key liye prabhaavi dhang seey kiya gayaa haye. proton radiotherapy koo haal hii mein tantrika tantra koo cumm vishaaktata pradaan karate hue, cadish see tumour key saath 10-vyakti key adhyayan mein prabhaavi dikhaaya gayaa haye.
chemotherapy.
chemotherapy kaa upayog ack bahuayami upchaar yojana mein aam taur parr adhik unnat, unrectable yaa phir seey honey vaale tumour key liye kiya jaataa haye. cyclophosphamide, winkristin aur doxorubicin kaa upayog shalya chikitsa seey pahale grade see asthesioneuroblastom key liye neoedjuvent chemotherapy davaaon key roop mein kiya gayaa haye, jisase uchit parinam praapt hotey hain. sisplatin aur etoposide kaa upayog aksar asthesioneuroblastom key ilaaj key liye neodjuvents yaa radiotherapy yaa sergery key saath sahayak key roop mein kiya jaataa haye.
adhyayan key parinam ashajanak hain. baal roga rogiyon mein unnat charan mein asthesioneuroblastom, jahaan sergery abb sambhav naheen haye, aakramak chemotherapy aur radiotherapy key parinamswarup kuchh tumour niyantran aur deerghakaalik uttarjeevita hui haye.
purvanuman.
asthesioneuroblastom ack dheema vikasit lekin ghaatak tumour haye jisaki shaaririk sthiti key kaaran uchch punaravritti darr hoti haye. tumour kii sanrachana, sthaan aur metastatic visheshtaon key saath-saath upchaar yojana purvanuman nirdhaarit karati haye. asthesioneuroblastom key liye samanya naidaanik vargeekaran pranaliyon mein kashish vargeekaran aur dulguerov vargeekaran shamil hain. kish vargeekaran key sheersh parr ooti-roga sambandhi visheshataaen cancer key purvanuman koo aur nirdhaarit curr sakati hain. gambhir, kashish varg see tumour mein, roga nidan key liye heim key rogvigyaan key grade mahatvapurna hain. nimn shreni key kish class see tumour vaale rogiyon mein uchch shreni key see tumour vaale rogiyon kii tulanaa mein 86 pratishat kii 10-varsh kii jeevit rahane kii darr hoti haye, jinaki jeevit rahane kii darr 28 pratishat hoti haye. uchch shreni key tumour vaale shalya chikitsa seey ilaaj kiye gaye rogiyon koo leptomaningial metastes yaa mastishk reedh kii huddy key taral padaarth kii bhagidari kaa anubhav honey kii adhik sambhavana hoti haye, joe aamtaur parr kewal sthaaniya punaravritti dekhane vaale nimn shreni key tumour vaale rogiyon key vipareet hotey hain.
ilaaj kiye gaye asthesioneuroblastom key liye jeevit rahane kii darr radiotherapy (65 pratishat) key saath sergery key liye sabse achchi haye, phir radiotherapy aur chemotherapy (51 pratishat) key liye, kewal sergery (48 pratishat), sergery, radiotherapy aur chemotherapy (47 pratishat) aur anta mein kewal radiotherapy (37 pratishat) key liye sabse achchi haye. saahitya seey, radiotherapy aur sergery rogiyon key liye sabse achchha parinam bataate hain. haalaanki, yeh samajhana mahatvapurna haye kii kuchh hudd taka, roga kaa nidan tumour kii gambhirta seey sambandhit haye. adhik pragati, uchch shreni key tumour key parinamswarup chemotherapy yaa radiotherapy ekmatra upchaar key roop mein hoga. yeh koee ashcharya kii baat naheen haye kii inn mamalon mein purvanuman badatar hoga.
ghatana.
prati duss laakh logon mein 0.40 mamalon key saath sabhi intranasal tumour kaa 2 pratishat asthesioneuroblastom haye. sanyukt raajya america mein 700 seey cumm mamle darj kiye gaye hain. vishva star parr 400 seey cumm advitiya mamle saamane aae hain. asthesioneuroblastom kissy bhee samay hoe sakata haye, jeevan key dusare aur chhathe dashakon mein charam ghatana kii soochana haye.
itihas.
asthesioneuroblastom pahali baar 1924 mein dekhaa gayaa thaa.
ullekhaniya mamle.
iss bimari koo mantra sebir key mamle seey pramukhta millie thee, joe iss bimari seey peedit thee aur ichchamrityu seey incar kiye jaane key baad usane apana jeevan samaapt curr liya thaa.

