
titistoxin

titistoxin ack vish haye joe upa-parivaar titine seey bichchu key vish mein paaya jaataa haye. voltage-nirbhar sodium aayan chainalon aur potasium chainalon seey judane seey, way sialoria, lacrimation aur rhinorrhea kaa kaaran banate hain.
srot.
bichchu chhah parivaaron mein vitarit kiye jaate hain. kewal boothiday parivaar key loga hii manushyon key liye khatarnak hain. iss parivaar key bheetar, upa-parivaar titine manushyon mein sabse adhik bichchu vishaaktata kaa kaaran banata haye. yeye prajaatiyan brazil (titius cerulatus, tii.) mein paaee jaati hain. bahiyensis "aur" tii. stigmurus) aur uttari aur dakshini venezuela (tii. visangatiyaan "). titius cerulatus" kaa jahar inmein seey sabse shaktishali haye.
rasayan vigyaan.
tii kaa kachcha jahar. cerulatus mein vibhinn vishaakt padaarth hotey hain. kuchh sabse majboot vyutpann neurotoxin titistoxin aur toxin tss-jee hain. dou prakaar key vishaakt padarthon koo mukhya vishaakt prabhaav key liye jimmedaar maanaa jaataa haih toxin gaama (ack β-prakaar kaa vish) aur titistoxin (tstx, ack α-prakaar kaa vish), donon sodium channel key saath ack vishisht sambandh key saath. anya prakaar key vish hainh tstx-keye, ack 37 emino acid, 61 emino acid avasheshon key saath toxin gaama (tstx-jee aur tstx-aaee) iss vish kaa pramukh neurotoxin haye. tstx-kβ kii ack lambi shrinkhala haye. key + channel avaruddh karane vaale peptides teen diasulphide pulon key saath 30-40 amino acid key ekal shrinkhala polypeptides hain. chaar diasulphide bandhanon vaalaa vish tstx-iv seey hotaa haye. isamen 41 amino acid avashesh hotey hain.
kaarravaai kaa tarika.
dou prakaar key vish dilchasp hainh α-bichchu vishaakt padaarth Na1 chainalon key 3 sthaan parr baandhate hain, jisase unaki nishkriyata dheemi hoe jaati haye. β-bichchu vishaakt padaarth site 4 parr baandhate hain, jisase Na1 dhaaraon (ina) key sakriyan koo adhik nakaratmak kshamata kii or sthanantarit kiya jaataa haye. titistoxin koshika vidhruveekaran kaa kaaran banata haye, naa + chainalon koo sakriya kartaa haye aur naa + grahan koo badhaata haye joe see. aeye. 2 + grahan koo prabhaavit curr sakata haye aur mastishk cortical slies seey acetylcholine (aeye. see. aich.) release koo badhaa sakata haye.
naa + channel.
α-vish sodium channel key upa-ikai 3 seey judate hain, nishkriyata koo dheema karate hain aur samay koo shikhar parr badale binaa shikhar dhaara koo badhaate hain. yeh koshika vidhruveekaran kaa kaaran banata haye joe calcium chainalon koo kholata haye jisase see. aeye. 2 + kaa pravaah hotaa haye, jisase aeye. aich. release hoti haye. sthir-avastha sakriyan aur nishkriyata vakr donon koo adhik nakaratmak kshamata mein sthanantarit curr diyaa jaataa haye.
key + channel.
tstx-i, ts1 yaa toxin gaama ack β-prakaar kaa vish haye joe receptor site 4 seey judataa haye aur sodium channel sakriyan kii voltage nirbharta koo adhik nakaratmak kshamataon mein sthanantarit kartaa haye. tstx-k chuninda roop seey voltage-gated gair-nishkriya (sambhavatah vilambit rectifier) k + chainalon koo cineptosome mein avaruddh kartaa haye.
vishaaktata.
titius cerulatus" kaa jahar prajaati key vishaakt padarthon mein sabse shaktishali haye. iss vish mein neurotoxin key beach sabse vishaakt protein titistoxin-1, tstx-aaee haye, jisamen kramshah 76 ± 9 aur 1.1 ± 0.3 microgram/kigra kaa antahshira aur intracisternal (mouse) hotaa haye. tii key ack shaktishali ghatak key roop mein tstx-aaee kii pehchaan. cerulatus vish ney ise iss vish seey pramukh aur mukhya neurotoxin key roop mein varnit kiya. manushya mein vishaakt prabhaav tii dwara utpann kiya jaataa haye. cerulatus vish sialoria, lacrimation aur rhinorrhea aur teevra agnashayshoth hain. adrenal granthiyon aur postganglionic tantrika terminals dwara catecholamine aur ganglion aur postganglionic tantrika terminals dwara aich taba jaari kiye jaate hain jaba jahar aataa haye. anya neurotransmitter bhee poore vish aur alag-thalag vishaakt padarthon dwara chhode jaate hain. choohon mein, titistoxin parisancharan aur shwasan pranaliyon parr naatakiya prabhaav daaltaa haye, jisamen hypotension, tachypnia, hyperpnia, attaxic aur saans lene mein saans lena shamil haye. inn praarambhik prabhaavon key baad, 5 yaa 10 microgram tii. aiss. tii. aiks. prerit uchch raktchaap aur hyperpnia. sabse badee khuraak ney lagbhag 70 minut baad apania aur mrityu kaa utpaadan kiya.
upchaar.
tii. aiss. tii. aiks. dwara prerit fefadon kii shoth phenobarbital dwara avaruddh hoti haye. khargosh anty-tii. aiss. tii. aiks. pee. antibody ney bichchu key vishaakt padarthon key saath cross-reactivity pradarshit kii aur "inn vitro" tatasth karane kii kshamata dikhaai. iss prakaar, yeh protein bichchu key dunk key upchaar mein upayog kiye jaane vaale antisserum key utpaadan key liye ack majboot ummidwar key roop mein ubharata haye. gair-vishaakt punarsanyoji protein parisanchari antibody key ack star koo prerit curr sakata haye joe titius toxin key vishaakt prabhaavon koo beasar karane key liye paryaapt haye aur naidaanik upayog key liye tatasth polyclonal antibody kii ack naee peedhi key utpaadan mein upayog key liye ack achchha ummidwar haye.

