
pierphenidone

pyrphenidone, jise anya key beach piraspa brand naam seey becha jaataa haye, ack dawa haye jiska upayog idiopathic pulmonary fibrosis key ilaaj key liye kiya jaataa haye. yeh vikas karakon aur procollegen I aur II key utpaadan key downeragulation key madhyam seey fefadon key fibrosis koo cumm karke kaam kartaa haye.
2008 mein naidaanik parikshanon key baad ise pahali baar japan mein idiopathic pulmonary fibrosis vaale logon key ilaaj key liye manjuri dee gaee thee. ise 2011 mein europeeya sangh mein, 2012 mein kanada mein aur octuber 2014 mein sanyukt raajya america mein upayog key liye manjuri dee gaee thee.
yeh ack samanya dawa key roop mein upalabdh haye.
chikitsa upayog.
europeeya sangh mein, pierphenidone koo halke seey madhyam idiopathic fuffusiya fibrosis key upchaar key liye sanket diyaa jaataa haye. ise 2011 mein europeeya dawa agency dwara anumodit kiya gayaa thaa. octuber 2008 mein, ise japan mein, 2010 mein bhaarat mein aur 2011 mein chean mein upayog key liye anumodit kiya gayaa thaa (2014 mein vaanijyik launch). octuber 2014 mein, ise sanyukt raajya america mein chikitsa upayog key liye anumodit kiya gayaa thaa. janwari 2017 mein sanyukt raajya america mein upayog key liye ack tablet sanskaran koo manjuri dee gaee thee.
mexico mein ise nishan aur fibrotic ootak key upchaar key liye ack jail key roop mein anumodit kiya gayaa thaa.
pratikool prabhaav.
jathrantra sambandhi.
pierphenidone aksar gastroentestinal dushprabhavon jaise kii dyspepsia, matali, gastritis, gastroesophageal reflux roga aur ulti seey judaa hotaa haye. inn pratikriyaon kii gambhirta koo cumm karane key liye, bhojan key baad pierphenidone liya jaanaa chaahiye.
twacha.
pierphenidone prakaash samvedansheelta pratikriyaon, chakatte, pruritus aur shushk twacha kaa kaaran banata haye. rogiyon koo aamtaur parr soorya key prakaash key seedhe sampark seey bachane kii salah dee jaati haye, jisamen soorya key deepak bhee shamil hain, aur surakshaatmak kapadon aur sunscreening agents kaa upayog karane kii salah dee jaati haye. nirantar prakaash samvedansheelta pratikriyaon koo aamtaur parr sthaaniya rogsoochak upchaar key saath-saath khuraak samaayojan aur yadi aavashyak hoe tou upchaar koo asthaayi roop seey bund karke prabandhit kiya jaataa haye.
yakrit kii shithilata.
pierphenidone yakrit enzyme key star koo badhaa sakata haye, vishesh roop seey aspartate transaminase, elenin transaminase aur gaama-glutamile transpeptidase key star koo; chikitsa key dauran yakrit enzyme key star kii aavadhik nigrani kii aavashyakta hoti haih chikitsa kii shuruat seey ack baar pahale, chikitsa kii shuruat key 6 maheene baad taka masik nigrani, aur usake baad 3 masik. yakrit sambandhi haani vaale rogiyon aur una rogiyon mein joe ack saath ack sipe1aeye2 avarodhak leey rahey hain, dawa likhate samay atirikt savdhani baratane kii aavashyakta hoti haye. dawa una rogiyon mein pratikool haye jinake yakrit mein gambhir haani haye.
chakkar aanaa aur thakan honah.
pierphenidone upchaar seey gujar rahey rogiyon mein chakkar aanaa aur thakan kii soochana millie haye. chakkar aanaa aam taur parr thheek hoe jaataa haye, halanki rogiyon koo mansik satarkata yaa samanvaya kii aavashyakta vaali gatividhiyon koo karane seey pahale pataa honah chaahiye kii way pierphenidone key prati kaise pratikriya karate hain. yadi gambhir haye, tou khuraak samaayojan yaa upchaar bund karane kii aavashyakta hoe sakati haye.
vajan ghataana.
pierphenidone seey ilaaj kiye gaye rogiyon mein vajan ghataane kii soochana millie haye. doctors koo rogiyon key vajan kii nigrani karni chaahiye aur yadi aavashyak hoe tou calori key sevan koo badhaane key liye protsaahit karna chaahiye.
antahkriyaaen.
adhikansh dawa antahkriyaaen vibhinn cytochrome pee450 enzymon dwara madhyasthata kii jaati hain.
sipe1aeye2 avarodhak.
choonki pierphenidone koo sipe1aeye2 enzyme maarg key madhyam seey chayapachaya kiya jaataa haye, isaliye iss enzyme koo rokane vaali koee bhee dawa pierphenidone kii vishaaktata koo cumm curr sakati haih sahavarti chikitsa seey bachana chaahiye. una rogiyon mein fluvoxamine koo pratibandhit kiya jaataa haye jinka pierphenidone key saath ilaaj kiya jaa rhaa haye. sipe1aeye2 key anya avarodhak jaise ciprofloxacin, ameodarone aur propaphenon kaa upayog savdhani key saath kiya jaanaa chaahiye.
anya sipe avarodhak.
kuchh pierphenidone koo sipe1aeye2 key alawa cytochrome pee450 enzymon dwara bhee chayapachaya kiya jaataa haye. isake parinamswarup, anya cytochrome pee450 enzymon jaise kii fluconazole (sipe2see9), chloramphenicol (sipe2see19), fluoxatin aur peroxetin (donon sipe2dee6) key majboot avrodhakon kaa savdhani key saath upayog kiya jaanaa chaahiye.
sipe1aeye2 prerak.
sipe1aeye2 key madhyam prerak jaise kii omeprazole kaa upayog savdhani key saath kiya jaanaa chaahiye kyonki way dawa key parisanchari plasma star koo cumm curr sakate hain.
sigaret peete hain.
sigaret peene seey sipe1aeye2 koo prerit karke pierphenidone kii nikasi mein vriddhi hoti haye, jisase dawa key sampark mein aanaa cumm hoe jaataa haye. rogiyon koo pierphenidone key saath chikitsa key dauran sigaret peene seey bachane kii salah dee jaani chaahiye.
pharmacology.
kaary pranali.
pyrphenidone mein vibhinn inn vitro pranaliyon aur fibrosis key pashu model mein achchi tarah seey sthaapit antifibrotic aur anty-inflammatory guna hain. kaee koshika-adharit adhyayanon seey pataa chalaa haye kii pierphenidone fibroblast prasaar koo cumm kartaa haye, vikas kaarak beeta uttejit collegen utpaadan koo parivartit kartaa haye aur vikas kaarak beeta koo parivartit karane jaise fibrogenic madhyasthon key utpaadan koo cumm kartaa haye. pierphenidone koo samvardhit koshikaon aur alag-alag maanav paridhiya rakt ack-paramanu koshikaon donon mein tumour necrosis kaarak alfa aur ill-1β jaise soojan madhyasthon key utpaadan koo cumm karane key liye bhee dikhaaya gayaa haye. yeye gatividhiyaan fibrosis key pashu model mein dekhi gaee vyaapak antifibrotic aur anty-inflammatory gatividhiyon key anuroop hain.
pharmacokinetics.
pierphenidone maukhik roop seey diyaa jaataa haye. halanki bhojan kii upasthiti avashoshan kii seema koo kaafee cumm curr detee haye, dawa key saath judey matali aur chakkar koo cumm karane key liye dawa koo bhojan key baad liya jaanaa chaahiye. dawa lagbhag 60 pratishat plasma protein seey judee hui haye, vishesh roop seey albumin seey. 50 pratishat taka dawa koo yakrit sipe1aeye2 enzyme pranali dwara chayapachaya kiya jaataa haye taaki 5-carboxypherphenidone, nishkriya chayapachaya utpann hoe sakey. prashaasit khuraak kaa lagbhag 80 pratishat sevan key 24 ghanton key bheetar mootra mein utsarjit hoe jaataa haye.
itihas.
iss dawa koo duniya bhar kii kaee companiyon dwara vikasit kiya gayaa thaa, jisamen mool patent dhaarak, marnac, intermune (abb roche kaa hissa), shiyonogi aur jee. aine. aaee. samooh shamil hain.
fibrosis key model mein poorv naidaanik adhyayan.
pashu model mein, pierphenidone ack pranaaleegat antifibrotic gatividhi pradarshit kartaa haye aur fefadon, yakrit, hriday aur gurde key fibrosis key jaiv rasayanik aur ooti-roga sambandhi soochkaankon koo cumm karane key liye dikhaaya gayaa haye.
pyrphenidone fuffusiya fibrosis key kaee pashu model mein ack susangat antifibrotic prabhaav pradarshit kartaa haye. inmein seey, bliomycin model fuffusiya fibrosis kaa sabse vyaapak roop seey upayog kiya jaane vaalaa model haye. iss model mein, bliomycin prashaasan key parinamswarup oxidative tanaav aur teevra soojan hoti haye, jisake baad choohe aur hamster sahit kaee jaanvaron kii prajaatiyon mein fuffusiya fibrosis kii shuruat hoti haye. kaee adhyayanon seey pataa chalaa haye kii pierphenidone bliomycin-prerit fuffusiya fibrosis koo cumm kartaa haye. ack adhyayan ney baar-baar bliomycin dene key baad 42 dinon kii avadhi mein pierphenidone key prabhaav kii jaanch kii. pyrphenidone key sevan seey fefadon kii edema aur fuffusiya fibrosis koo cumm kiya gayaa jaba fefadon kii kshati key saath upchaar shuru kiya gayaa thaa. iss adhyayan ney fuffusiya protein abhivyakti kaa mulyankan kiya aur paaya kii pierphenidone upchaar ney proinflammatory aur fibrogenic protein kii samanya abhivyakti koo paaya. fuffusiya fibrosis mein isi tarah kii kamee taba dekhi gaee jaba pyrphenidone upchaar mein taba taka deree hui jaba taka kii fuffusiya fibrosis sthaapit naheen hoe gayaa aur aage naheen badh rhaa thaa.ee. jaba rognirodhi upchaar key vipareet ack chikitsiya mein prashaasit kiya jaataa haye.
pierphenidone kaa antifibrotic prabhaav cardiac (hriday), renal (gurda), aur hepatic (yakrit) fibrosis key saath-saath duputrain key anubandh key pashu model mein bhee sthaapit kiya gayaa haye. inn models mein, pierphenidone ney fibrosis koo cumm karane aur fibrogenic madhyasthon kii abhivyakti kii ack susangat kshamata kaa pradarshan kiya.
pyrphenidone koo spondyloarthritis fibroblast jaise sinoviocytes aur austioblast inn vitro koo rokane key liye bhee dikhaaya gayaa haye.
idiopathic pulmonary fibrosis mein naidaanik pareekshan.
pyrphenidone kii naidaanik prabhavkarita kaa adhyayan teen charan III mein kiya gayaa haye, joe idiopathic pulmonary fibrosis key rogiyon mein yaadrichhik, double-blind, placebo-niyantrit adhyayan haye.
idiopathic pulmonary fibrosis key rogiyon key upchaar key liye pierphenidone kii prabhavkarita aur suraksha kaa mulyankan karane key liye pahale charan III naidaanik pareekshan japan mein aayojit kiya gayaa thaa. yeh ack bahu-kendra, yaadrichhik, dohare-andhe, pareekshan thaa, jisamen idiopathic pulmonary fibrosis vaale 275 rogiyon koo yaadrichhik roop seey 52 saptah key liye pierphenidone 1800 milligram/dinn (110 rogi), pierphenidone 1200 milligram/dinn (56 rogi), yaa placebo (109 rogi) praapt karane key liye saunpa gayaa thaa. pierphenidone 1800 yaa 1200 milligram/dinn ney placebo kii tulanaa mein mahatvapurna kshamata mein ausat girawat koo aadhar rekha seey saptah 52 taka cumm curr diyaa. placebo kii tulanaa mein pierphenidone key saath pragati-mukt uttarjeevita mein bhee sudhaar kiya gayaa thaa.
europe, uttari america aur australia key gyaarah deshon mein dou yaadrichhik, dohare-andhe, placebo-niyantrit charan III adhyayan. idiopathic fuffusiya fibrosis vaale rogiyon koo yaadrichhik roop seey cumm seey cumm 72 saptah key liye maukhik pierphenidone yaa placebo key saath upchaar key liye saunpa gayaa thaa. adhyayan 004 mein, pierphenidone ney jabaran mahatvapurna kshamata mein girawat koo cumm curr diyaa. saptah 72 mein aff. vee. see. mein ausat parivartan pierphenidone 2403 milligram/dinn samooh mein-8.0% aur placebo samooh mein-12.4% thaa, 4.4% kaa antar. 174 mein seey paintees (20 pratishat) banaam 174 rogiyon mein seey 60 (35 pratishat) kii balpurvak jeevan shakti mein cumm seey cumm 10 pratishat kii girawat aaee. adhyayan 06 mein, saptah 72 mein jabaran mahatvapurna kshamata parivartan mein samoohon key beach kaa antar saankhyikiya roop seey mahatvapurna naheen thaa. saptah 72 mein jabaran mahatvapurna kshamata aff. vee. see. mein ausat parivartan pierphenidone samooh mein-9.0% aur placebo samooh mein-9.6% thaa. saptah 72 mein anumaanit balpurvak mahatvapurna kshamata mein parivartan mein samoohon key beach antar mahatvapurna naheen thaa.
maee 2014 mein, ack aur yaadrichhik, dohare-andhe, placebo-niyantrit pareekshan key parinam prakaashit kiye gaye, jisamen 555 rogiyon koo namankit kiya gayaa thaa. unhone pichhale naidaanik adhyayanon seey tippaniyon kii pushti kii kii pierphenidone ney idiopathic fuffusiya fibrosis kii pragati koo kaafee cumm curr diyaa jaisa kii pratishat mein parivartan dwara maapa gayaa haye joe kii aadhaarbhut rekha seey saptah 52 taka anumaanit balpurvak mahatvapurna kshamata mein parivartan haye. isake alawa, chhah minut kii paidal pareekshan doori parivartan aur pragati-mukt uttarjeevita key donon pramukh maadhyamik antim binduon parr mahatvapurna upchaar prabhaav dikhaae gaye they. teen adhyayanon seey 1,247 vishayon kii ekatrit aabaadi key ack poorv-nirdisht vishleshan seey pataa chalaa haye kii placebo samooh kii tulanaa mein pierphenidone samooh mein sabhi karanon seey mrityu darr kaa jokhim 48 pratishat cumm hoe gayaa thaa.
cochrane sahyog dwara kii gaee ack sameeksha ney nishkarsh nikala kii pyrphenidone pragati-mukt uttarjeevita mein sudhaar kartaa haye aur idiopathic fuffusiya fibrosis key rogiyon mein fuffusiya kaary koo cumm prabhaav detaa haye. idiopathic pulmonary fibrosis vaale vayask rogiyon mein placebo yaa steroid key saath gair-steroid davaaon kii tulanaa karane vaale yaadrichhik adhyayan shamil kiye gaye they. pierphenidone upchaar key chaar placebo-niyantrit parikshanon kii sameeksha kii gaee, jisamen kull 1155 rogi shamil they. metaa-vishleshan key parinam seey pataa chalaa kii pierphenidone roga key badhane key jokhim koo 30 pratishat taka cumm curr detaa haye. isake alawa, dou japani adhyayanon key metaa-vishleshan ney placebo kii tulanaa mein aadhar rekha seey mahatvapurna kshamata mein parivartan parr pierphenidone key laabhkaari prabhaav kii pushti kii.
viniyaamak pragati.
maee 2010 mein, yuu.aiss. khaadya aur dawa prashaasan (aff. dee. aeye.) ney idiopathic pulmonary fibrosis key ilaaj key liye pierphenidone key upayog koo manjuri dene seey incar curr diyaa, aur atirikt naidaanik parikshanon kaa anurodh kiya. disambar 2010 mein, europeeya dawa agency (ee. aim. aeye.) key ack salaahkaar panel ney dawa kii manjuri kii sifarish kii. farwari 2011 mein, europeeya aayog ney sabhi 27 europeeya sangh key sadasya raajyon mein vipanan pradhikaran pradaan kiya aur chean key khaadya aur aushadhi prashaasan ney sitambar 2011 mein manjuri dee. isake baad, yuu. aiss. mein ack yaadrichhik, charan III pareekshan puuraa kiya gayaa.aiss. 2014 mein, yuu mein niyaamak anumodan key saath.aiss. kuchh hii samay baad.
octuber 2010 mein, bhaaratiya company sipla ney dawa koo "peerphenex" key roop mein launch kiya, aur msn prayogshalaon ney ise "pulmofib" key roop mein launch kiya. ise 2011 mein europeeya sangh mein "asbriot" brand naam key tahat upayog key liye anumodit kiya gayaa thaa; ise 2012 mein kanada mein isi naam key tahat anumodit kiya gayaa thaa; aur octuber 2014 mein sanyukt raajya america mein "asbriot" key roop mein bhee anumodit kiya gayaa thaa. sitambar 2011 mein, cheeni raajya khaadya aur aushadhi prashaasan ney jee. aine. aaee. samooh limitted koo chean mein pierphenidone kii naee dawa anumodan pradaan kiya, aur baad mein 2013 mein "atturi" key brand naam key tahat nirmaan anumodan pradaan kiya.
2014 mein, ise mexico mein "kitosel ell. pee.". key naam seey anumodit kiya gayaa thaa, joe fuffusiya fibrosis aur yakrit fibrosis key liye sanketit haye. mexico mein ise puraane ghaavon aur twacha kii choton key ilaaj key liye jail mein bhee manjuri dee gaee haye aur maukhik roop seey ise fuffusiya fibrosis aur yakrit fibrosis key ilaaj key liye manjuri dee gaee haye.
shodh karein.
anya shodhon seey pataa chalata haye kii pyrphenidone puraane yakrit fibrosis key liye ack prabhaavi anty-fibrotic upchaar hoe sakata haye.