
11β-hydroxysteroid dehydrogenase prakaar 1

11β-hydroxysteroid dehydrogenase type 1, jise cortisone reductage key roop mein bhee jaanaa jaataa haye, ack naduff-nirbhar enzyme haye joe yakrit, vasaa ootak aur kendriya tantrika tantra sahit pramukh chayapachaya ootakon mein atyadhik vyakt kiya jaataa haye. inn ootakon mein, hsd11bee1 cortisone koo sakriya harmon courtisol mein cumm curr detaa haye joe glucocorticoid receptors koo sakriya kartaa haye. yeh laghu-shrinkhala nirjalikaran key parivaar seey sambandhit haye. yeh jeane dwara kootbaddh haye.
kaary.
iss jeane dwara kootbaddh protein ack sookshm enzyme haye joe tanaav harmon courtisol key nishkriya chayapachaya cortisone mein parivartan koo utprerit kartaa haye. isake alawa, encoded protein vipareet pratikriya koo utprerit curr sakata haye, cortisone koo courtisol mein parivartit curr sakata haye. bahut adhik courtisol kendriya motape kaa kaaran bunn sakata haye, aur iss jeane mein ack vishesh bhinnata bachchon mein motape aur insulin pratirodh key saath judee hui haye. iss jeane key liye ack hii protein koo encoding karane vaale dou pratilekh roop paae gaye hain.
naidaanik mahatva.
11β-hsd1 koo carbenoxolone dwara rokaa jaataa haye, joe aamtaur parr peptic alsar key upchaar mein upayog kii jaane vaali dawa haye. isake alawa, "glycerhiza glabra" kii jarh seey 18-alfa-glycyrhysic acid koo ack avarodhak key roop mein khoja gayaa thaa.
salicillate motey choohon mein vasaa ootak mein 11β-hsd1 abhivyakti koo cumm kartaa haye aur isaliye yeh samajha sakata haye kii aspirin type 2 madhumeh mein glycemic niyantran mein sudhaar kyon kartaa haye. hurry chaay seey epigalocatechin gallet bhee iss enzyme koo prabal roop seey roque sakata haye; hurry chaay vibhinn phenolics kaa ack jatil mishran haye jisamen utpaadan aur prasanskaran key saath samagri bhinn hoti haye, aur kuchh phenolics gyaat aich. dee. aeye. see. avarodhak hain joe aanuvanshik abhivyakti koo badal dete hain. jaise kii aamtaur parr hurry chaay mein sevan kiya jaataa haye, vaha raktapravaah mein kharaab tareeke seey avashoshit hotaa haye. thhos nishkarshon parr pahunchane key liye aur adhik shodh kii aavashyakta haye.