epoitin alfa

epoitin alfa ack maanav erythropoietin haye joe punah sanyojak dee. aine. aeye. praudyogiki kaa upayog karke koshika samvardhan mein utpaadit hotaa haye. 28 agast 2007 koo europeeya dawa agency dwara adhikrit, yeh erythropoisis (laal rakt koshika key star koo badhaana) koo uttejit kartaa haye aur iska upayog anaemia key ilaaj key liye kiya jaataa haye, joe aamtaur parr purani gurde kii viphalata aur cancer chemotherapy seey judaa hotaa haye.
apoetin kaa nirmaan aur vipanan emen dwara brand naam apogen key tahat kiya jaataa haye. johnson aind johnson kii sahayak company gensen biotech (poorv mein ortho biotech utpaad, ell. pee.), ack utpaad licenses samjhaute key anusaar, procrit naam seey ack hii dawa bechati haye. yuu mein prati rogi ausat laagat.aiss. 2009 mein $8,447 thaa. darbepoitin alfa (rinn) erythropoietin kaa ack glycosylation analogue haye jisamen dou atirikt aine-linked carbohydrate shrinkhalaaen hain, jinhen amgen dwara nirmit aur vipanan kiya jaataa haye, jisamen eranesp kaa ack brand naam haye. khaadya aur aushadhi prashaasan (aff. dee. aeye.) kii chetaavaniyan aur procrit, apogen aur erenesp key liye suraksha saavdhaaniyaan samaan hain.
kaee varshon seey, apoetin alfa ney yuu. aiss. dwara bhugtan kiye gaye sabse badey dawa kharch key liye jimmedaar haye.aiss. chikitsa pranali; 2010 mein, karyakram ney dawa key liye $2 billion kaa bhugtan kiya. kuchh adhyayanon mein paaya gayaa haye kii haemoglobin key star koo badhaana ghanastrata kii ghatnaaon, aghaat aur mrityu key uchch jokhimon seey judaa huaa haye.
yeh vishva swaasthya sangathan kii aavashyak davaaon kii soochi mein haye.
chikitsa upayog.
erythropoietin standhari koshika samvardhan mein punarsanyoji dee. aine. aeye. praudyogiki dwara utpaadit ack chikitsiya agent key roop mein upalabdh haye. iska upayog cancer (chemotherapy aur vikiran) key upchaar seey purani gurde kii bimari aur myelodysplasia key parinamswarup honey vaale anaemia key ilaaj mein kiya jaataa haye.
gurde kii bimari key kaaran honey vaalaa anaemia.
jinn logon koo dialysis kii aavashyakta hoti haye yaa unhein purani gurde kii bimari haye, unake liye lauh koo erythropoietin key saath diyaa jaanaa chaahiye, joe kii ferritin aur transferrin santripti jaise kuchh prayogshala maapdandon parr nirbhar kartaa haye. yuu mein dialysis key mareej.aiss. aksar apogen diyaa jaataa haye; anya deshon mein apoetin key anya brandon kaa upayog kiya jaa sakata haye.
erythropoietin kaa upayog purani gurde kii bimari vaale logon mein anaemia key ilaaj key liye bhee kiya jaataa haye joe dialysis parr naheen hain (joe charan 3 yaa 4 kii bimari mein hain aur joe gurde pratyaropan key saath rahate hain). purani gurde kii bimari key kaaran anaemia vaale logon key liye dou prakaar key erythropoietin hotey hain (dialysis parr naheen).
cancer key kaaran honey vaalaa anaemia.
march 2008 mein, yuu. key. key liye salaahkaaron kaa ack panel.aiss. khaadya aur aushadhi prashaasan (aff. dee. aeye.) ney cancer rogiyon mein upayog key liye bajar mein emen aur johnson aur johnson dwara utpaadit erythropoisis-uttejak agents (ee. aiss. aeye.) koo rakhane mein sahaayata kii. aff. dee. aeye. ney kuchh naidaanik parikshanon key adhyayan parinamon parr apani chinta kendrit kii haye joe kii anaemia-rodhi davaaon koo lene vaale chemotherapy rogiyon mein mrityu aur tumour key vikas key badhate jokhim koo darshaata haye.
gambhir roop seey beemar logon mein anaemia.
erythropoietin kaa upayog gambhir bimari key parinamswarup anaemia vaale logon key ilaaj key liye kiya jaataa haye.
ack yaadrichhik niyantrit pareekshan mein, erythropoietin koo gambhir roop seey beemar rogiyon dwara aavashyak rakt aadhaan kii sankhya koo badalane key liye naheen dikhaaya gayaa thaa. iss adhyayan mein ack aashcharyajanak nishkarsh erythropoietin praapt karane vaale rogiyon mein mrityu darr mein ack chhoti see kamee thee. yeh parinam 29 dinon key baad saankhyikiya roop seey mahatvapurna thaa lekin 140 dinon mein naheen. aghaat key liye aaee. see. yuu. mein bharti rogiyon mein mrityu darr kaa antar sabse adhik thaa. lekhak iss cumm mrityu darr key sambhaavit kaaran key liye kaee parikalpanaaen pradaan karate hain, lekin, ghanastrata mein gyaat vriddhi aur aghaat rogiyon mein badhe hue laabh key saath-saath shalya chikitsa rogiyon mein seemant gair-mahatvapurna laabh (0.9 kaa samaayojit jokhim anupaat) koo dekhate hue, yeh anuman lagaaya jaa sakata haye kii kuchh laabh erythropoietin key procogulant prabhaav key liye gauna hoe sakate hain. isake bavjood, iss adhyayan seey pataa chalata haye kii yeh dekhane key liye aage key shodh kii aavashyakta hoe sakati haye kii erythropoietin key prashaasan seey kaun seey mahatvapurna dekhbhal vaale rogi, yadi koee hain, tou labhanvit hoe sakate hain. erythropoietin key upayog key kissy bhee laabh koo ghanastrata kii badhati sambhavana key khilaf taula jaanaa chaahiye, joe kaee parikshanon mein pradarshit kiya gayaa haye.
tantrika sambandhi roga.
erythropoietin koo schizophrenia aur stroke jaisi kuchh tantrika sambandhi beemariyon key ilaaj mein fayademand maanaa gayaa haye. kuchh shodhon ney sujhaav diyaa haye kii erythropoietin mastishk maleria vaale bachchon mein jeevit rahane kii darr mein sudhaar kartaa haye, joe mastishk mein maleria parjivi key rakt vaahikaon key avrodh key kaaran hotaa haye. haalaanki, yeh sambhavana kii erythropoietin neuroprotective hoe sakata haye, mastishk mein rasayan key kharaab parivahan aur neuronal koshikaon parr vyakt erythropoietin receptors key nimn star key saath asangat haye.
mansik roga
yaadrichhik naidaanik niyantran parikshanon ney sangyaan mein sudhaar mein ee. pee. oh. key ashajanak parinam dikhaae hain joe aksar manodasha vikaaron aur schizophrenia key vartamaan upchaar key saath durgam hotaa haye.inn kshetron mein dhyaan, smriti aur karyakari kaary mein jatil sangyanatmak prasanskaran kii gati shamil haye.
samay seey pahale janm lene vaale shishu.
jaldi paida honey vaale shishuon koo aksar laal rakt koshikaon key saath aadhaan kii aavashyakta hoti haye aur unamen erythropoietin kaa star cumm hotaa haye. samay seey pahale janm lene vaale shishuon mein anaemia koo cumm karane key liye ack upchaar vikalp key roop mein erythropoietin kaa adhyayan kiya gayaa haye. 8 dinn seey cumm umr key shishuon kaa erythropoietin seey ilaaj karane seey laal rakt koshika aadhaan kii aavashyakta thodi cumm hoe sakati haye, lekin retinopathy kaa khatra badh jaataa haye. seemit naidaanik laabh aur retinopathy key badhate jokhim key kaaran, samay seey pahale shishuon key liye praarambhik yaa dair seey erythropoietin upchaar kii sifarish naheen kii jaati haye.
pratikool prabhaav.
epoitin alfa aam taur parr achchi tarah seey sahan kiya jaataa haye. aam dushprabhavon mein uchch raktchaap, sirdard, cluster migraine (upchaar key liye pratirodhi) koo aksham karna, jodon mein dard aur injection sthal parr thakka jamana shamil hain. injection dene key baad kuchh ghanton key bheetar injection dene vaali jagah parr dunk lagane, twacha parr chakatte aur flue jaise lakshan (jodon aur maanspeshiyon mein dard) key durlabh mamle saamane aae hain. allergy pratikriyaon, daure aur ghanastrata kii ghatnaaon sahit adhik gambhir dushprabhaav (jaise.jee.dill kaa daura, stroke aur fuffusiya ambolism) shayed hii kabhi hotey hain. dawa key deerghakaalik swa-prashaasan seey rakt haemoglobin aur hematocrit mein asamanya roop seey uchch star taka vriddhi hoti haye, jisake parinamswarup dyspania aur pett dard hotaa haye.
erythropoietin gurde kii bimari key rogiyon mein pratikool hriday sambandhi jatilataon key badhate jokhim seey judaa huaa haye yadi iska upayog 13 graam/dee. ell. seey oopar haemoglobin key star kii vriddhi koo lakshit karane key liye kiya jaataa haye.
erythropoietin key saath praarambhik upchaar (ack shishu key 8 dinn key honey seey pahale) samay seey pahale aur anaemic shishuon mein samay seey pahale honey vaali retinopathy key jokhim mein vriddhi key saath sahsambaddh haye, jisase yeh chinta badh jaati haye kii erythropoietin kii angiogenic kriyaaen retinopathy koo badhaa sakati hain. choonki anaemia swayam retinopathy key jokhim koo badhaata haye, erythropoietin upchaar key saath sahsambandh aakasmik hoe sakata haye.
anaemic cancer key rogiyon mein suraksha salah.
amgen ney janwari 2007 mein ack "priya doctor" patra bheja jisamen cancer pareekshan key haal key anaemia key parinamon koo ujagar kiya gayaa thaa, aur doctors koo savdhani key saath usa off-label sanket mein upayog karane parr vichaar karane kii chetavani dee gaee thee.
amgen ney yuu koo salah dee.aiss. dahanka 10 naidaanik pareekshan key parinamon key sambandh mein khaadya aur dawa prashaasan (fda). dahanka 10 detta nigrani samiti ney paaya kii aranesp key saath ilaaj kiye gaye vishayon mein teen saal kaa loko-kshetriya cancer niyantran una logon kii tulanaa mein kaafee kharaab thaa joe aranesp (pee = 0.01) praapt naheen curr rahey they.
inn salahon key jawab mein, fda ney ack saarvajanik swaasthya salah jaari kii
9 march 2007 koo, aur 16 farwari 2007 koo doctors key liye ack naidaanik chetavani, apogen aur darbepoitin jaise erythropoisis-uttejak agents (ee. aiss. aeye. aiss.) key upayog key baare mein. paramarsh ney chemotherapy yaa off chemotherapy praapt karane vaale cancer rogiyon mein inn agents kaa upayog karane mein savdhani baratane kii sifarish kii, aur inn sthitiyon mein jeevan kii gunavatta yaa aadhaan aavashyaktaon mein sudhaar kaa samarthan karane key liye naidaanik sakshya kii kamee kaa sanket diyaa.
isake alawa, 9 march 2007 koo, dawa nirmaata inn davaaon kii suraksha key baare mein naee black boxes chetavaniyon parr sahmat hue.
22 march 2007 koo, samachar media mein erythropoetic vikas karakon kii suraksha mein ack congress kii jaanch kii soochana dee gaee thee. nirmaataon koo chikitsakon key liye dawa chhoot karyakramon koo nilambit karane aur rogiyon koo davaaon key vipanan koo nilambit karane key liye kahaa gayaa thaa.
kaee prakashanon aur aff. dee. aeye. sancharon ney chayanit samoohon mein ee. aiss. aeye. chikitsa key pratikool prabhaavon seey sambandhit chinta key star koo badhaa diyaa haye. ack sanshodhit black boxes chetavani mein, fda mahatvapurna jokhimon koo nott kartaa haye, yeh salah dete hue kii ee. aiss. aeye. kaa upayog kewal cancer key rogiyon mein kiya jaanaa chaahiye jaba vishesh roop seey chemotherapy key kaaran honey vaale anaemia kaa ilaaj kiya jaanaa chaahiye, naa kii anaemia key anya karanon key liye. isake alawa, chetavani mein kahaa gayaa haye kii rogi kaa chemotherapy pathyakram puuraa honey key baad ee. aiss. aeye. koo bund curr diyaa jaanaa chaahiye.
antahkriyaaen.
erythropoietin key saath dawa kii antahkriya mein shamil hainh
samaaj aur sanskriti.
uchch khuraak vaale epoitin key laabhon parr sawal uthaane vaale ack sampadakiya key prakaashan koo ack patrika kii vipanan shakha dwara sampadakiya shakha dwara sweekaar kiye jaane key baad radd curr diyaa gayaa thaa, jisamen prakaashan mein hiton key takraav kii chintaon koo ujagar kiya gayaa thaa.
2011 mein, lekhak cathleen sharp ney ack pustak prakaashit kii, "rakt kalahh vaha vyakti jisane abb taka kii sabse ghaatak davaaon mein seey ack parr ct bajaai",
dawa nirmaata johnson aind johnson ney doctors koo uchch khuraak mein epoitin likhane key liye protsaahit kiya, vishesh roop seey cancer rogiyon key liye, kyonki isase bikri mein saikadon million dollar kii vriddhi hogi. poorv bikri pratinidhiyon maark duxbury aur deane mcclenane ney daavaa kiya kii aspatalon aur kleenikon koo epoitin bechane vaale unake vyavasaay kaa badaa hissa chikitsa dhokhadhadi thee, joe kull arabon thee.
biosemiller.
agast 2007 mein, europeeya sangh mein upayog key liye binocrit, epoitin alfa hexel aur ubseimed koo manjuri dee gaee thee.

