
ferrier carbocyclisation

ferrier carbocyclisation (yaa ferrier II pratikriya) ack carbonic pratikriya haye jise pahali baar carbohydrate rasaayanagya robert jey dwara report kiya gayaa thaa. 1979 mein ferrier. yeh inol eather pyrance seey cyclohexanone kii ack dhaatu-madhyasth punarvyavastha haye. aamtaur parr, yeh pratikriya paaraa lavan, vishesh roop seey paaraa (ii) chloride dwara utprerit hoti haye.
kaee sameekshaaen prakaashit kii gaee hain.
pratikriya tantra.
ferrier ney nimnalikhit pratikriya tantra kaa prastaav rakhaah
iss tantra mein, antim olephine pahale madhyavarti, yaugik 2, ack hemiacital kaa utpaadan karane key liye hydroxymercuration seey gujarta haye. isake baad, methanol khou jaataa haye aur dicarbonyl yaugik electrophilic aldehyde parr hamale key madhyam seey chakrakar hoe jaataa haye aur utpaad key roop mein carbocycle banaata haye. iss pratikriya kaa ack nakaratmak paksh yeh haye kii anomeric sthiti (carbon-1) parr ch3h key nuksan key parinamswarup α-aur β-anomers kaa mishran hotaa haye. pratikriya pratisthaapit alkien (ee. jee. terminal alkien parr ack-oac samooh honah).
ferrier ney yeh bhee bataaya kii antim utpaad, yaugik 5, koo acetic enhydride (assie2oh) aur pyridine key saath pratikriya dwara sanyugmit keaton (yaugik 6) mein parivartit kiya jaa sakata haye, jaisa kii neeche dikhaaya gayaa haye.
sanshodhan.
1997 mein, sinai aur saha-kaaryakartaon ney sanshleshan key liye ack vaikalpik maarg (neeche dikhaaya gayaa haye) kii soochana dee jisamen anomeric sthiti (glycosidic bonned) parr bandhan kaa daraar shamil naheen thaa. iss mamle mein, baney pramukh utpaad ney anomeric sthiti mein apane mool vinyas koo banaae rakhaa thaa.
sinai ney prastaavit kiya kii yeh pratikriya nimnalikhit sankraman avastha seey gujareeh
sinai ney yeh bhee paaya kii titanium (iv) vyutpann jaise [tikl3 (oh "aaee" pr)] levis acid key ack halke sanskaran, "aaee"-boo3ell key roop mein usee pratikriya mein kaam karate hain, joe ack samaan sankraman sthiti seey gujarta haye jisamen anomeric kendra mein vinyas kaa pratidhaaran shamil haye.
1988 mein, addam ney pratikriya key ack sanshodhan kii soochana dee jisamen paladium (ii) lavanon kii utprerak matra kaa upayog kiya gayaa, jisase adhik paryaavaran key anukool tareeke seey inol eather koo karbosugar mein parivartit kiya gayaa.
anuprayog.
ferrier carbocyclisation kaa vikas carbocycle samooh vaale kaee praakritik utpaadon key sanshleshan key liye upayogi rhaa haye. 1991 mein, bender aur saha-karmchaariyon ney iss pratikriya kaa upayog karate hue "maayo"-innocitol vyutpannon key shuddh ananciomers key liye ack synthetic maarg kii soochana dee. ise barton aur sahakarmiyon dwara kiye gaye kaam mein aminocyclitol key sanshleshan parr bhee lagu kiya gayaa haye. anta mein, emano "aur anya."1998 mein jatil sanyugmit cyclohexanone koo sanshleshit karane key liye ferrier sthitiyon kaa upayog kiya gayaa.

