
finrenon

finrenon, jise brand naam kerendia key tahat becha jaataa haye, ack dawa haye jiska upayog gurde key kaary mein girawat, gurde kii viphalata, hriday gati seey mrityu, gair-ghaatak hriday daure aur type 2 madhumeh seey judey puraane gurde kii bimari vaale vayaskon mein hriday viphalata key liye aspatal mein bharti honey key jokhim koo cumm karane key liye kiya jaataa haye. finerenone ack gair-steroidal khanij-corticoid receptor virodhi (aim. aar. aeye.) haye.
samanya dushprabhavon mein hyperclemia (potasium kaa uchch star), hypotension (nimn raktchaap), aur hyponetramia (sodium kaa nimn star) shamil hain.
sanyukt raajya america mein julaai 2021 mein aur europeeya sangh mein farwari 2022 mein chikitsa upayog key liye finarenone koo manjuri dee gaee thee.aiss. khaadya aur aushadhi prashaasan ise pratham shreni kii dawa maanata haye.
chikitsa upayog.
sanyukt raajya america mein, finerenone koo gurde key kaary mein girawat, gurde kii viphalata, hriday mrityu, gair-ghaatak hriday daure aur type 2 madhumeh seey judee purani gurde kii bimari vaale vayaskon mein hriday viphalata key liye aspatal mein bharti honey key jokhim koo cumm karane key liye sanket diyaa jaataa haye.
europeeya sangh mein, vayaskon mein type 2 madhumeh seey judee purani gurde kii bimari (albuminuria key saath charan 3 aur 4) key upchaar key liye finerenone kaa sanket diyaa jaataa haye.
pharmacology.
vartamaan mein upalabdh aldosterone antigonist jaise kii applerenone aur spironolectone kii tulanaa mein anya steroid harmon receptors key saath finerenone kaa cumm saapeksh sambandh haye, jisake parinamswarup strirog, napunsakta aur cumm kamechha jaise cumm pratikool prabhaav honey chaahiye.
finerenone khanij-corticoid receptors koo avaruddh kartaa haye, joe ise potasium-bachaav mootravardhak banaata haye.
yeh talika teen antiminerlocorticoids kii avarodhak (avaruddh) sandrata (aaee. see. 50, ikaaih aine. aim.) kii tulanaa karati haye. mineralocarticoid receptor avrodh davaaon kii vaanchhit kaarravaai key liye jimmedaar haye, jabaki anya receptors key avrodh seey sambhaavit roop seey dushprabhaav hotey hain. cumm moolyon kaa arth haye majboot avrodh.
uparokt soochibaddh davaaon mein astrogen receptor key liye mahatvaheen lagaav hotaa haye.
finerenone aiss810ell utparivartan koo aashray dene vaale khanij-corticoid receptors key liye ack virodhi key roop mein kaary kartaa haye, anya paaramparik mr avrodhakon jaise kii spironolectone aur applerenone key vipareet joe sanyog seey agonist key roop mein kaary karate hain.
saat yaadrichhik niyantrit parikshanon (13,783 pratibhagiyon) key detta key metaa-vishleshan mein madhumeh gurde kii bimari aur adhik proteinuria vaale logon mein finerenone kaa upayog karane kaa laabh paaya gayaa.
pratikool prabhaav.
finerenone electrolyte asantulan kaa kaaran bunn sakata haye jise ack swaasthya seva peshevar dwara hull kiya jaanaa chaahiye. potasium key mamle mein, finarenone lene vaale rogiyon koo rakt mein potasium key uchch star kaa anubhav hoe sakata haye. iss naidaanik khoj seey sambandhit lakshnon mein matali, kamjori, chhaati mein dard aur andolan kii haani shamil hain. ack anya samanya electrolyte asantulan joe finarenone parr rogiyon key liye hoe sakata haye, vaha yeh haye kii rogiyon mein cumm sodium hoe sakata haye, joe sirdard, bhram, kamjori aur rogiyon key liye santulan seey baahar mahsoos karane key roop mein prakat hoe sakata haye.
itihas.
gurde aur hriday key parinamon mein sudhaar key liye finarenone kii prabhavkarita kaa mulyankan type 2 madhumeh seey judey puraane gurde kii bimari vaale vayaskon mein ack yaadrichhik, bahu-kendra, dohare-andhe, placebo-niyantrit adhyayan mein kiya gayaa thaa. iss adhyayan mein, 5,674 pratibhagiyon koo yaadrichhik roop seey yaa tou finerenone yaa placebo praapt karane key liye saunpa gayaa thaa.
adhyayan ney una pratibhagiyon kii sankhya key liye dou samoohon kii tulanaa kii, jinaki bimari ack samagr (yaa sanyukt) antim bindu taka badhee, jisamen gurde key kaary mein cumm seey cumm 40 pratishat kii kamee, gurde kii viphalata kii pragati, yaa gurde kii mrityu shamil thee. parinamon seey pataa chalaa kii 2,833 pratibhagiyon mein seey 504 jinhone finerenone praapt kiya, unamen seey cumm seey cumm ack ghatana samagr antim bindu mein thee, jabaki 2,841 pratibhagiyon mein seey 600 ney placebo praapt kiya thaa.
yuu.aiss. khaadya aur aushadhi prashaasan (aff. dee. aeye.) ney fineranone prathamikta sameeksha aur twarit padnaamon key liye aavedan pradaan kiya. aff. dee. aeye. ney bayer swaasthya seva koo kerendia kii manjuri dee.
samaaj aur sanskriti.
kanuni sthiti.
16 disambar 2021 koo, europeeya dawa agency (ee. aim. aeye.) kii maanav upayog key liye aushadhiya utpaadon (see. aich. aim. pee.) kii samiti ney ack sakaratmak raay apnai, jisamen vayaskon mein type 2 madhumeh seey judee purani gurde kii bimari key upchaar key liye aushadhiya utpaad kerendia key liye ack vipanan pradhikaran dene kii sifarish kii gaee. iss aushadhiya utpaad key liye aavedak bayer aeye. jee. haye. farwari 2022 mein europeeya sangh mein chikitsa upayog key liye finerenone koo manjuri dee gaee thee.
shodh.
charan II arts-dn adhyayan mein, madhumeh gurde kii bimari key rogiyon mein finarenone khuraak-mootra albumin seey creatinine anupaat koo cumm karati haye. inn nishkarshon key aadhar parr, finarenone kaa adhyayan badey charan III fidelio aur figaro parinam adhyayanon mein kiya jaa rhaa haye, joe yeh aaklan karane key liye design kiya gayaa haye kii kyaa finarenone purani gurde kii bimari aur type 2 madhumeh key rogiyon mein see. key. dee. pragati aur pratikool hriday sambandhi ghatnaaon key jokhim koo cumm kartaa haye. inn parikshanon ney 13,000 seey adhik rogiyon koo namankit kiya haye, jinake 2020 mein anumaanit fidelio aur 2021 mein figaro key praathamik puuraa honey key saath.

