
spirotetronet cyclays abue

spirotetronet cyclays abue ack enzyme haye joe abisomicin see biosynthetic maarg mein deals-elder pratikriya koo utprerit karane key liye jimmedaar haye. abue dwara utprerit iss yaugik key jaiv sanshleshan mein ack pramukh charan mein intramolicular [4 + 2] cyclodation shamil haye-jise dials-elder pratikriya key roop mein bhee jaanaa jaataa haye-ack heterobicyclic ring system agradoot banaane key liye jisamen tetronic acid aur ack cyclohexin ring hoti haye joe spiro-linked hoti haye.
abue ack praakritik deals-alderes haye joe samudri actinomycet "verucosispora maris" mein paaya jaataa haye. abisomichin see, abue kii madad seey sanshleshit, bacterial follet chayapachaya kaa ack shaktishali avarodhak haye. yeh mycobacterium tapedik aur staphylococcus aureus key bahu-dawa pratirodhi naidaanik isolates key khilaf prabhaavi haye. abue bahut cumm enzymon mein seey ack haye joe pericyclic pratikriyaon koo utprerit karane mein saksham hain joe prabhaavi roop seey regioselective aur stereoselective carbon-carbon bonned banaate hain.
sanrachana.
deals-alderes dou samaan, aathh-fanse hue, antiparal beeta-bairal kaa ack diamer haye. nalika kaa aadhar glue19 aur aarg122 kii side-chain key beach ack namak pull key gathan dwara ack saath rakhaa jaataa haye. samaan mahatva kaa enzyme key pravesh dwaar parr ack lachili loop sanrachana kii upasthiti haye, joe nalika key beeta sheet 1 aur 2 key beach sandwich haye. loop key uddeshya kaa anuman substrate viniyog key dauran sakriya karane aur ack dhakkan key roop mein kaary karane key liye lagaaya jaataa haye joe utpreran hotaa haye. bairal key bheetar, yeh mukhya roop seey hydrophobic bull hain joe substrate key saath baatchit karate hain.
tantra.
deals-alderes abue usa pratikriya koo utprerit kartaa haye jisake parinamswarup abisomicin see key liye poorvavarti anu kaa gathan hotaa haye. yeh ack thhos, atulyakaalik deals-elder tantra key madhyam seey kartaa haye jaisa kii quantum yantriki/aanvik yantriki (qm/mimi) md anukaran dwara ingit kiya gayaa haye. uchch-stariya ghanatva karyatmak siddhant gananaaen aim. dee. anukaranon dwara kiye gaye nishkarshon kaa samarthan karati hain, joe enzyme key utpaad key liye sankraman sthiti koo darshaati hain joe see13-see14 aur see10-see15 key beach bandhan kii lambai koo kramshah 2.00å aur 2.69å honey kaa sanket detee hain. gais avastha dee. aff. tii. ganana seey yeh bhee pataa chalata haye kii anu kii sankraman sthiti dls elder endo utpaad banaana pasand karati haye. sanrachanaatmak roop seey, substrate key dyne aur dynophyll kramshah tii. aar. pee. 124 aur pee. ee. 41 key paas paae jaate hain; tyre76 lactone carbonyl key saath hydrogen bandhan mein bhaag letaa haye joe substrate vishishtata mein sahaayata karane key liye bhavishyavani kii jaati haye.
javic kaary.
jaisa kii oopar ullekh kiya gayaa haye, abue abisomichin see key utpaadan mein ack pramukh enzyme haye, joe aminodoxychorismate synthes (adc) kaa pahala sanrachana-adharit avarodhak paaya gayaa thaa. chorismic acid koo pee-aminobenzoic acid (pabaa) mein badalane key liye aeye. dee. see. mahatvapurna haye. pabaa koo jivaanuon key astitva key liye aavashyak maanaa jaataa haye. iss prakaar, abisomichin see jivanurodhi dawa key design key liye ack aakarshak lakshya kaa pratinidhitva kartaa haye.
abue kaa upayog karke sanshleshit kiye jaa sakane vaale adhik abisomichin see vyutpann hain. udaaharan key liye, abue ack anya deals-alderes, abmu key mool substrate koo abisomicin 7 banaane mein parivartit curr sakata haye jisamen jivanurodhi guna bhee hotey hain. yeh vibhinn jivanurodhi padarthon key utpaadan koo utprerit karane key liye abue kii kshamata koo darshaata haye.
audyogik kaary.
substrate aur abue key utpaad kii hydrophobicity key kaaran, vighatan mein sahaayata karane aur ektrikaran koo rokane key liye carbonic vilayakon kii aavashyakta hoti haye. abue kaa sanshodhan iss mudde koo hataa sakata haye, jisase audyogik settings mein isaki dakshata mein sudhaar hoe sakata haye. protein bioconjugation aur pagillation sahit kaee sanshodhan maarg prastaavit kiye gaye hain. protein jaiv sanyugman dou sanyugmit proteins key gunon koo samanvit kartaa haye. pagillation protein key saath polyethylene glycol koo jodata haye joe paani kii ghulansheelata aur taapiya sthirata mein sudhaar curr sakata haye. halanki, taapiya sthirata mein vriddhi aavashyak naheen hoe sakati haye; abue teji seey vikrit naheen hotaa haye aur 60 degree celsius key baad taka utprerak gunon koo naheen khota haye. abue kii sanrachanaatmak akhandata koo aage rasayanik vikriti jaise kii gwanidinium chloride mein mudey rahane kii kshamata seey pradarshit kiya jaataa haye.
vikas.
sakshya bataate hain kii abue jaise enzyme joe pericyclic pratikriyaon koo utprerit karate hain, unaki vikaasvaadi utpatti samaan hoti haye. unamen seey kaee mein anty-parallel β-bairal topology haye; una sabhi mein 2 elin oxide cyclays (aoc) jaise domen (pf18678) hain, jisamen 8-stranded anty-parallel β-bairal key saath-saath kaee anya samanya domen hain. unaki topology bhee bahut samaan haye aur una sabhi mein β-bairal core fold haye. haalaanki, sakriya sthal vastukala kaa koee mahatvapurna sanrakshan naheen dekhaa gayaa haye. anya sanrakshit avashesh vibhinn substrate key liye parivartansheel hoe sakate hain.

