
golgi matricks

golgi matricks golgi upkaran kii sanrachana aur kaary mein shamil protein kaa ack sangrah haye. matricks koo pahali baar 1994 mein 12 proteins key ack anakar sangrah key roop mein alag kiya gayaa thaa joe detergent (jisane golgi jhilli koo hataa diyaa) aur 150 mimi nackle (jisane kamjor roop seey judey protein koo hataa diyaa) kii upasthiti mein ack saath judey rahey. protease enzyme key saath upchaar ney matricks koo hataa diyaa, jisane matricks sanrachana key liye protein key mahatva kii pushti kii. aadhunik freeze aichi electron microscopy (ee. aim.) spasht roop seey ack jaali dikhaati haye joe golgi cysterna aur sambandhit putikaon koo jodati haye. ack matricks key astitva key liye aage kaa samarthan ee. aim. chhaviyon seey aataa haye joe darshaata haye kii ribosome koo golgi cysterna key beach aur paas key kshetron seey baahar rakhaa gayaa haye.
sanrachana aur kaary.
matricks key pahale vyaktigat protein ghatak kii pehchaan 1995 mein golgin aeye2 (taba jee. aim. 130 kahaa jaataa thaa) key roop mein kii gaee thee. taba seey, kaee anya golgin parivaar key protein golgi matricks mein paae gaye hain aur vibhinn tarikon seey golgi jhilli seey judey hue hain. udaaharan key liye, gmap210 (golgi microtubul seey judey protein 210) mein aine-termal 38 emino acid mein ack alps (empepathic lipid-packing sensor) rupankan hotaa haye aur see-terminus parr grab (grip-related arf-binding) naamak ack arf1-binding domen hotaa haye. iss prakaar, hadapane kaa kshetra apratyaksh roop seey golgi cysterna seey juda sakata haye aur iska alps rupankan putikaon koo baandh sakata haye.
golgin mein kundalit-kundal kshetra hotey hain aur iss prakaar inki lambai 200 nm taka lambi sanrachana honey kii bhavishyavani kii jaati haye. adhikansh paridhiya jhilli protein hain joe ack chhor parr golgi jhilli seey judey hotey hain. unake paas kundalit-kundal kshetra key beach lacheele kshetra hain, joe unhein gatishil putika docking seey golgi cysterna aur golgi kii gatishil sanrachana key liye madhyasthata karane key liye aadarsh ummidwar banaate hain.
golgi ree-assembly-stacking protein golgi matricks mein protein kaa ack vikaasvaadi roop seey sanrakshit parivaar haye. grasp65 aur grasp55 2 maanav grasp hain. inn proteins kaa naam ack "inn vitro" parakh key dauran sateek golgi punah sanyojan key liye unaki aavashyakta seey rakhaa gayaa thaa, lekin unhein "inn vivo" mein kaary karane key liye bhee dikhaaya gayaa haye, jaisa kii saath mein chitra mein dikhaaya gayaa haye. grasp lipid dwistariya key saath judate hain kyonki way myristoilit hotey hain aur unake myristic acid avashesh lipid parat mein aapas mein mill jaate hain. unake "trance" oligomerization koo phosphorylation dwara niyantrit kiya jaataa haye aur maanaa jaataa haye kii yeh mitosis key dauran aavashyak roop seey golgi key vikhandan kii vyakhya kartaa haye.