
anjir

folliculogenesis-vishisht mool helix-loop-helix, jise germaline alfa (figalfa) yaa pratilekhan kaarak figa mein kaarak key roop mein bhee jaanaa jaataa haye, ack protein haye jise manushyon mein "figla" jeane dwara kootbaddh kiya jaataa haye. figla jeane ack roganu koshika-vishisht pratilekhan kaarak haye joe adhimaantah andkoshon mein vyakt kiya jaataa haye joe maanav gunasutra 2p13.3 parr paaya jaa sakata haye.
kaary.
yeh jeane ack protein koo kootbaddh kartaa haye joe prasavottar andkosh-vishisht jeane abhivyakti mein kaary kartaa haye. protein ack buniyaadi helix-loop-helix pratilekhan kaarak haye joe kaee andkosh-vishisht jeane koo niyantrit kartaa haye, jisamen folliculogenesis, andkosh vibhedan aur jonaa pellucida koo kootbaddh karane vaale jeane shamil hain. figla jonaa pellucida jeane jdp1, jdp2 aur jdp3 seey sambandhit haye.
naidaanik mahatva.
figla jeane mein utparivartan samay seey pahale dimbagranthi kii viphalata seey judey hotey hain. samay seey pahale dimbagranthi kii viphalata ack aanuvanshik vikaar haye joe hypergonadotropic dimbagranthi kii viphalata aur baanjhapan kii or leey jaataa haye. aisaa maanaa jaataa haye kii manushyon mein samay seey pahale dimbagranthi kii viphalata figla haploninsficency key kaaran hoti haye, joe adim rome key gathan koo baadhit karati haye. yeh anjir choohon key nockout mein dekhaa gayaa thaa, jinhone apane prajanan jeevan kaal key dauran romika antarvriddhi koo cumm curr diyaa thaa aur andakoshika key nuksan koo tej curr diyaa thaa. anjir mein utparivartan vaali mahilaaon koo samay seey pahale andashay kii viphalata kaa ack roop dikhaaya gayaa thaa. saath hii saath adim rome banaane mein viphalata key kaaran, nockout choohon mein jonaa pellucida jeane jdp1, jdp2 aur jdp3 abhivyakti kii bhee kamee thee.