
spitz (protein)

spitz falon kii makkhiyon mein ack protein haye joe epidermal groth factor receptor (ee. jee. aff. aar.) kaa pramukh sakriyak haye.
kaary.
spitz kaa utpaadan endoplasmic reticulum mein ack transmembrane protein key roop mein kiya jaataa haye. vahaan yeh "starr" naamak ack malvahak receptor key saath judataa haye aur golgi mein taskari kii jaati haye. golgi mein, spitz koo "romboid" naamak ack protease dwara vibhajit kiya jaataa haye, joe spitz koo koshika jhilli mein taskari karane aur koshika seey baahar nikalane key liye chhodata haye. yahaan seey yeh receptor koo sakriya karate hue anya koshikaon kii satah parr egfr koo baandh sakata haye. vaikalpik roop seey, spitz koo argos dwara bandha aur nishkriya kiya jaa sakata haye, joe ee. jee. aff. aar. sakriyan koo rokta haye.
spitz "drosophila" epidermal groth factor receptor (dair) key sanket koo sakriya karane key liye jimmedaar haye aur falon kii makkhiyon key bhroon, aankho aur pankhon key vikas mein shamil haye. spitz koo protein argos (aos) dwara dair seey baandhane seey rokaa jaa sakata haye joe phir epidermal groth factor receptor maarg koo rokta haye. epidermal groth factor receptors kii adhik abhivyakti maanav cancer mein yogdan detee haye, isaliye sakriya ligand kaa prithakkaran cancer key upchaar key liye egfr ligand koo cumm karane key tarikon koo vikasit karane mein upayogi hoe sakata haye.
sanrachana.
protein spitz sanrachanaatmak roop seey vikas kaarak-α (tii. jee. aff.-α) koo badalane key samaan haye aur "drosophila" jaise gurken aur kerron mein paae jaane vaale anya proteins key saath tii. jee. aff.-α kaa ack samroop haye. inn proteins koo ack transmembrane protein, starr aur ack protease, romboid (row) dwara sansaadhit kiya jaataa haye. spitz epidermal groth factor receptor koo baandhata haye aur niyantrit kartaa haye. 
epidermal groth factor receptor (ee. jee. aff. aar.) binding.
ee. jee. aff. aar. ack diamer key roop mein maujood haye, aur dou spitz protein receptor key kaary koo niyantrit karane key liye usase judate hain. diamer koo dou upa-ikaaiyon key roop mein sandarbhit kiya jaataa haih baaen haath kii upa-ikai aur daaen haath kii upa-ikai. donon upa-ikaaiyon parr dou spitz proteins kaa bandhan samaan naheen haye, kyonki alag-alag amino acid avashesh donon taraf key bandhan mein bhaag lete hain. daahine haath kii or, egfr key aarg21 aur aarg26, spitz key avasheshon aeye. aiss. aine. 50 aur iley51 key saath antahkriya karate hain. baayin or, diamer key dusare hisse key aarg21 aur aarg26 ack anya spitz protein key glue53 aur iley51 key saath baatchit karate hain. spitz protein ee. jee. aff. aar. upa-ikaaiyon mein seey ack key aaee aur aaee. aaee. domen koo alag curr sakata haye, baad mein domen aaee koo domen aaee. aaee. seey door sthanantarit curr sakata haye aur ee. jee. aff. aar. upa-ikai kii side chain key beach naee baatchit kaa kaaran bunn sakata haye. shodh seey pataa chalaa haye kii ee. jee. aff. aar. key liye spitz ligand key bandhan mein nakaratmak sahyogita haye, jahaan diamer key liye dusare ligand kii bandhan ghatana ack dusare key liye receptors kii aatmiyata koo cumm curr detee haye. diamer kii vishishtata, autophosphorylation, tantra aur anya vyavhaar taba kaafee badal sakate hain jaba yeh spitz protein key dohare kabje seey kamjor hoe jaataa haye. 

