
azacitidine

azacitidine, jise anya logon key beach vidaja brand naam key tahat becha jaataa haye, ack dawa haye jiska upayog myelodysplastic syndrome, myeloid leukemia aur kishore myelomonocytic leukemia key upchaar key liye kiya jaataa haye. yeh cytidine kaa ack rasayanik anuroop haye, joe dee. aine. aeye. aur aar. aine. aeye. mein ack nucleoside haye. azacitidine aur isake doxy vyutpann, decitabine (jise 5-ezaa-2′-deoxycytidine key roop mein bhee jaanaa jaataa haye) koo pahali baar chekoslovakia mein cancer key liye sambhaavit chemotherapetic agents key roop mein sanshleshit kiya gayaa thaa.
kishore myelomonocytic leukemia vaale bachchon mein sabse aam pratikool pratikriyaon mein pyrexia, daane, oopari shwasan path kaa sankraman aur anaemia shamil hain.
chikitsa upayog.
azacitidine koo myelodysplastic syndrome key upchaar key liye sanket diyaa jaataa haye, jisake liye ise yuu dwara anumodan praapt huaa.aiss. 19 maee, 2004 koo khaadya aur aushadhi prashaasan (aff. dee. aeye.). dou yaadrichhik niyantrit parikshanon mein sahayak upchaar key liye azacitidine kii tulanaa karate hue, azacitidine praapt karane key liye yaadrichhik kiye gaye myelodysplastic syndrome vaale 16 pratishat vishayon mein rakt koshikaon kii ginati aur asthi majja morphology kaa poorna yaa aanshik saamaanyikaran thaa, jabaki kissy koo bhee sahayak dekhbhal praapt naheen hui thee, aur lagbhag dou-tihai rogiyon koo jinhen azacitidine praapt karane key baad rakt aadhaan kii aavashyakta naheen thee.
myeloid leukemia aur kishore myelomonocytic leukemia key upchaar key liye bhee azacitidine kaa sanket diyaa jaataa haye. azacitidine aur venetoclex key sanyojan koo bhee aim. ell. key liye anumodit kiya jaataa haye.
kaarravaai kaa tantra.
azacitidine nucleoside cytidine kaa ack rasayanik analogue haye, joe dee. aine. aeye. aur aar. aine. aeye. mein maujood hotaa haye. aisaa maanaa jaataa haye kii isamen dou tantron key madhyam seey antinoplastic gatividhi hoti haye-cumm khuraak parr, dee. aine. aeye. methyltransferase koo rokkar, dee. aine. aeye. kaa hypomethylation karakar, aur uchch khuraak parr, asthi majja mein asamanya hematopoietic koshikaon key liye isaki pratyaksh cytotoxicity dwara dee. aine. aeye. aur aar. aine. aeye. mein isake samavesh key madhyam seey, jisake parinamswarup koshika kii mrityu hoti haye. azacitidine ack ribonucleoside haye, isaliye ise dee. aine. aeye. kii tulanaa mein adhik hudd taka aar. aine. aeye. mein shamil kiya jaataa haye. isake vipareet, decitabin (5-ezaa-2 '-deoxycytidine) ack deoxyribonucleiode haye, isaliye yeh kewal dee. aine. aeye. mein shamil hoe sakata haye. azacitidine key aar. aine. aeye. mein shamil honey seey polyribosome kaa prithakkaran, doshpurna methylation aur sthanantaran aar. aine. aeye. key sweekaarak kaary aur protein key utpaadan kaa avrodh hotaa haye. dee. aine. aeye. mein isake shamil honey seey dee. aine. aeye. methyltransferess key saath sahsanyojak bandhan hotaa haye, joe dee. aine. aeye. sanshleshan koo rokta haye aur baad mein cytotoxicity kii or leey jaataa haye. yeh maanav pratiraksha kamee virus "inn vitro" aur maanav tii-lymphotropic virus key khilaf prabhaavi dikhaaya gayaa haye.
methylation kaa avrodh.
azacitidine jaise azenucleosides koo 5-ezaa-2′-deoxycytidine-trifosphate (urf, decitabine-trifosphate) mein chayapachaya key baad, unhein dee. aine. aeye. mein shamil kiya jaa sakata haye aur azacitocin koo cytosine key liye pratisthaapit kiya jaa sakata haye. azesitocin-guanine dynucleotide koo dee. aine. aeye. methyltransferess dwara substrate key roop mein pahachaana jaataa haye, joe ack nucleophilic hamale dwara methylation pratikriya koo utprerit kartaa haye. isake parinamswarup cytosine ring key carbon-6 paramanu aur enzyme key beach ack sahsanyojak bandhan hotaa haye. bandhan koo aam taur parr carbon-5 paramanu key madhyam seey beeta-unmoolan dwara hull kiya jaataa haye, lekin yeh baad kii pratikriya azesitocin key saath naheen hoti haye kyonki isake carbon-5 koo nitrogen dwara pratisthaapit kiya jaataa haye, jisase enzyme sahsanyojak roop seey dee. aine. aeye. seey bandha hotaa haye aur isake dee. aine. aeye. methyltransferase kaary koo avaruddh curr detaa haye. isake alawa, sahsanyojak protein adduction bhee dee. aine. aeye. kii karyakshamta seey samjhauta kartaa haye aur dee. aine. aeye. kshati sanket koo trigger kartaa haye, jisake parinamswarup fanse hue dee. aine. aeye. methyltransferess kaa ksharan hotaa haye. parinamswarup, dee. aine. aeye. pratikriti key dauran methylation key nishan khou jaate hain.
vishaaktata.
azacitidine anaemia (cumm laal rakt koshika ginati), neutropania (cumm shwet rakt koshika ginati), aur thrombocytopania (cumm platelet ginati) kaa kaaran banata haye, aur rogiyon koo cumm seey cumm pratyek khuraak chakr seey pahale apane poore rakt kii ginati kii lagaatar nigrani karni chaahiye. khuraak koo nadir kii ginati aur hematologic pratikriya key aadhar parr samaayojit kiya jaa sakata haye.
yeh gambhir yakrit haani vaale rogiyon mein hepatotoxic bhee hoe sakata haye, aur metastatic roga key kaaran vyaapak yakrit tumour vaale rogiyon mein azacitidine upchaar key dauran pragatisheel yakrit komaa aur mrityu vikasit hui haye, vishesh roop seey jaba unakaa albumin star 30 graam/ell seey cumm hoe. yeh unnat ghaatak yakrit tumour vaale rogiyon mein pratibandhit haye.
uchch seeram creatinine seey laker gurde kii viphalata aur mrityu taka, gurde kii vishaaktata, myelodysplastic syndrome key alawa anya sthitiyon key liye anya chemotherapetic agents key saath sanyojan mein antahshira azacitidine key saath ilaaj kiye gaye rogiyon mein darj kii gaee haye. azacitidine aur atoposide key saath ilaaj kiye gaye puraane milogenous leukemia (ack asweekrit upayog) vaale paanch rogiyon mein renal tubeler acidosis vikasit huaa, aur renal haani vaale rogiyon koo renal vishaaktata kaa khatra badh sakata haye. azacitidine aur isake chayapachaya mukhya roop seey gurdon dwara utsarjit hotey hain, isaliye purani gurde kii bimari vaale rogiyon koo anya dushprabhavon key liye bariki seey nigrani kii jaani chaahiye, kyonki unake azacitidine key star mein uttarottar vriddhi hoe sakati haye.
pashu adhyayan aur isaki kriya key tantra key aadhar parr, azacitidine bhroon koo gambhir kshati pahuncha sakata haye. prajanan kshamata kii yaun sakriya mahilaaon koo azacitidine praapt karate samay aur antim khuraak key baad ack saptah key liye garbhanirodhak kaa upayog karna chaahiye, aur prajanan kshamata kii mahila bhagidaron key saath yaun sakriya purushon koo upchaar key dauran aur antim khuraak key baad teen maheene key liye garbhanirodhak kaa upayog karna chaahiye.
choohon mein tantrika vyavhaar sambandhi asaamaanyataon parr ack dinn key azesitidine (5-azac) key sampark mein aaney key tatkaal aur deerghakaalik prabhaavon kaa mulyankan karane key liye kiye gaye ack adhyayan mein paaya gayaa kii 5-azac upchaar dwara dee. aine. aeye. methylation kaa nishedh neurodegeneration kaa kaaran banata haye aur atirikt koshikiya sanket-viniyamit kinnez (aeye. aar. key. 1/2) sakriyan aur navjat choohon mein gatividhi-viniyamit cytoskeleton-sambaddh (chaap) protein abhivyakti koo baadhit kartaa haye aur vayask choohon mein vyavhaar sambandhi asaamaanyataon koo prerit kartaa haye, kyonki vikas key dauran synaptic circuit kii uchit paripakvata key liye dee. aine. aeye. methylation-madhyasth tantra aavashyak prateet hotaa haye, aur 5-azac dwara iss prakriya mein vyavadhaan asamanya kaary kaa kaaran bunn sakata haye.
azacitidine matali, ulti, bukhaar, dast, isake injection sthalon parr laali, kabj, chot, petia, kathorta, kamjori, raktapravaah mein asamanya roop seey cumm potasium key star aur kaee anya dushprabhavon kaa kaaran bhee bunn sakata haye, jinamen seey kuchh gambhir yaa ghaatak bhee hoe sakate hain.
itihas.
kishore myelomonocytic leukemia key ilaaj key liye azacitidine kii prabhavkarita kaa mulyankan ezaa-jey. aim. aim. ell.-1001 (aine. see. tii. 2447666) mein kiya gayaa thaa, joe kishore myelomonocytic leukemia vaale 18 baal rogiyon mein hematopoetic stame cell pratyaropan seey pahale pharmacokinetics, pharmacodynamics, suraksha aur azacitidine kii gatividhi kaa mulyankan karane key liye ack antarrashtriya, bahu-kendra, open-label adhyayan haye.
shodh.
dee. aine. aeye. seey methyl samoohon koo hataane key liye azacitidine kaa upayog "inn vitro" mein kiya jaa sakata haye. yeh methylation seey pahale honey vaale jeane silencing tantra key prabhaavon koo kamjor curr sakata haye. kuchh methylations koo ack shaant sthiti mein dee. aine. aeye. koo surakshit karane key liye maanaa jaataa haye, aur isaliye demilation maun sanketon kii sthirata koo cumm curr sakata haye aur saapeksh jeane sakriyan pradaan curr sakata haye.
azacitidine choohon mein isocitrate dehydrogenase-1 utparivarti glioma genographt parr tumour pratigaman koo prerit kartaa haye.
shodh mein, 5-azacitidine kaa upayog aamtaur parr vayask stame koshikaon key cardiomyocyte vibhedan koo badhaava dene key liye kiya jaataa haye. haalaanki, yeh sujhaav diyaa gayaa haye kii iss dawa kii ack dill key vibhedan kaarak key roop mein prabhavkarita mein kamee aaee haye kyonki yeh hriday koshikaon key kankal key myocytes mein antar koo badhaava detee haye.
azacitidine kaa pashu adhyayanon key saath-saath isake cancer-rodhi karyon mein bhee antiviral prabhaav hotaa haye, lekin naidaanik upayog key liye iska pareekshan naheen kiya gayaa haye.

