
break staging

break staging dou vidhiyon koo sandarbhit kartaa haye jinka upayog parkinsons roga aur alzheimer roga mein pathology kii degree koo vargeekrit karane key liye kiya jaataa haye. inn vidhiyon kaa upayog anusandhaan aur inn rogon key naidaanik nidan donon key liye kiya jaataa haye aur mastishk key shav pareekshan dwara praapt kiya jaataa haye.
parkinsons roga.
parkinsons roga kii mukhya rogjanak visheshta substantia nigra mein koshika mrityu haye. vishesh roop seey, yeh mrityu pars compact key nilay bhaag mein hoti haye, jisamen rogi kii mrityu key samay seey 70 pratishat taka koshikaaen prabhaavit hoti hain. jinn tantron seey mastishk kii koshikaaen nasht hoe jaati hain, way vividh hain. ack tantra mein kshatigrast koshikaon mein protein alfa-synuclean kaa asamanya sanchay hotaa haye joe ubquitin seey bandha hotaa haye. yeh protein sanchay samavesh banaata haye jise levi boddy kahaa jaataa haye.
break kaa siddhant.
parkinsons roga mein avastha kaa varnan 2003 mein heiko break dwara kiya gayaa thaa. break aur sahyogiyon kaa kahana haye kii parkinsons roga taba shuru hotaa haye jaba ack videshi agent naak yaa jathrantra pranali key madhyam seey shareer mein pravesh kartaa haye aur kendriya tantrika tantra (see. aine. aiss.) mein yatra kartaa haye. aantr aur paridhiya tantrika tantra mein lilly boddy kii upasthiti unake daave kaa samarthan karati haye. yeh lvi boddy pathology chuninda roop seey see. aine. aiss. key madhyam seey yatra karati haye, joe patale aur badey paimaane parr gair-myelinated neurons koo lakshit karati haye. break aur anya.isaliye, ack staging system vikasit kiya joe roga kii pragati koo darshaata haye. iss pranali koo chhah alag-alag charanon mein vibhajit kiya gayaa haye, jisamen pratyek charan koo vishesh tantrika sanrachanaon mein asamanya vikriti key liye jimmedaar thaharaaya gayaa haye. lakshan vigyaan key sandarbh mein, lakshnon kaa prakaar aur gambhirta break charanon key madhyam seey pragati seey sambandhit haye. praarambhik charanon mein gair-motor lakshan hotey hain, jaise kii gandh yaa kabj kii bhavna mein kamee. motor lakshan aksar madhya-charan kii sthiti key aspas pradarshit hotey hain, aur sangyanatmak lakshan baad mein break charanon mein pahunchane key saath utpann hotey hain. break aur unake sahayogi aage bataate hain kii roga aant kii tantrika tantra mein shuru hotaa haye aur yoni tantrika key madhyam seey see. aine. aiss. mein pravesh kartaa haye.
charan 1.
roga nichale mastishk tantra aur ghraan pranali kii sanrachanaon mein shuru hotaa haye. vishesh roop seey, medula oblongata aur poorvavarti ghraan kendrak mein vegus tantrika kaa prishthiya motor kendrak prabhaavit hotaa haye. iss charan mein golakar levi nikaayon kii tulanaa mein dhaage jaise alfa-synuclean samuchchay, levi neurites adhik prachalit hain.
charan 2.
charan 1 mein dekhi gaee vikriti key alawa, charan 2 mein medula oblongata key raif naabhik aur gigantocellular reticular naabhik mein atirikt ghaav hotey hain. roga taba mastishk key tantra koo oopar leey jaataa haye, joe medulary sanrachanaon seey ponteen tagmentum mein locus cerulus taka jaataa haye. charan 1 key samaan, levi neurites kii sankhya levi boddy seey adhik haye.
charan 3.
charan 3 kii shuruat mein, roga substantia nigra mein pravesh curr gayaa haye aur pars compact mein shareer key ghaav banane lagate hain. iss charan key uttaraardh mein roga kii pragati mainrut key besal naabhik mein hoti haye, joe besal forebrane mein acetylcholine seey bharpur neurons kaa ack samooh haye. aage, charan 1 aur 2 mein prabhaavit sanrachanaaen adhik dubli dehon kaa vikas karna shuru curr detee hain.
charan 4.
charan 4 kii visheshta haye pars compact mein gambhir dopaminergic koshika vinash. mesocortex aur allocortex kii bhagidari bhee haye; neocortex aprabhaavit rahata haye. vishesh roop seey, rogvigyaan koo amigdala aur thalamus key upa-naabhik mein dekhaa jaa sakata haye. poorvavarti ghraan naabhik koo mahatvapurna kshati hoti haye.
charan 5.
yeh roga neocortex parr aakraman karna shuru curr diyaa haye aur laukik, paarshvik aur frontal lobe kii sanrachanaon mein fail gayaa haye. koshika mrityu koo substantia nigra, vegus tantrika key prishthiya motor naabhik, gigantocellular reticular naabhik aur locus cerulus mein dekhaa jaa sakata haye.
charan 6.
roga ney poori tarah seey neocortex parr aakraman curr diyaa haye, joe mastishk mein motor aur samvedi kshetron koo prabhaavit kartaa haye. yeh bimari sabse gambhir haye.
alzheimer roga.
alzheimer roga mein charan kaa varnan 1991 mein break dwara kiya gayaa thaa. break charanon I aur II kaa upayog taba kiya jaataa haye jaba neurofibrillary ulajhan mukhya roop seey mastishk key transantorinal kshetra taka seemit hoti haye, charan III aur IV jaba hippocampus jaise limbic kshetron kii bhagidari bhee hoti haye, aur v aur vi jaba vyaapak neocortical bhagidari hoti haye. ise vriddhavastha pattika kii bhagidari kii degree key saath bhramit naheen kiya jaanaa chaahiye, joe alag tarah seey aage badhati haye.

