
atticaprant

phenoxy)-3-fluorobenzamide
atticaprant, jise isake vikasatmak code jnj-67953964, crc-501, aur laai-2456302 dwara bhee jaanaa jaataa haye, ack κ-opioid receptor (core) virodhi haye joe pramukh avasaadgrastata vikaar key upchaar key liye vikas key tahat haye. dawa kii manjuri key liye ack niyaamak aavedan 2025 taka prastut kiye jaane kii ummeed haye.
atticaprant key dushprabhavon mein anya key beach khujali shamil haye. atticaprant core key ack chayanaatmak virodhi key roop mein kaary kartaa haye, joe antajanan opioid peptide dynorphine kaa javic lakshya haye. dawa mein microid receptor (morr) aur anya lakshyon parr core key liye achchi chayanaatmaktaa haye, 30 seey 40 ghante kaa apekshaakrit lamba aadhaa jeevan, aur kendriya prabhaav paida karane key liye aasaani seey rakt-mastishk baadha koo paar kartaa haye.
atticaprant koo mool roop seey ellie lilly dwara vikasit kiya gayaa thaa, joe kuchh samay key liye sericor dwara vikasit kiya jaa rhaa thaa, aur abb jansen pharmaceuticals dwara vikasit kiya jaa rhaa haye. julaai 2022 taka, yeh pramukh avasaadgrastata vikaar key liye charan 3 naidaanik parikshanon mein haye. vartamaan mein pramukh avasaad key upchaar key liye naidaanik jaanch key tahat anya kappa opioid virodhi kii tarah, isaki prabhavkarita see. aine. aiss. key bheetar microglia mein pro-inflammatory cytokins key countervailing sakriyan seey samjhauta kiya jaa sakata haye.
atticaprant sharaab, kokeen upayog vikaar aur dhumrapan seey bachane key upchaar key liye bhee vikas key adheen thaa, lekin inn sanketon key liye vikas bund curr diyaa gayaa thaa.
pharmacology.
pharmacodynamics.
atticaprant ack shaktishali, chayanaatmak, alp-abhinay (i.ee., gair-"nishkriya") core kaa virodhi (kii = 0.81 nm banaam. 24.kramshah, 0 nm aur 155 nm, microne-opioid receptor (morr) aur δ-opioid receptor (door) key liye; core key liye lagbhag 30 gunaa chayanaatmaktaa). dawa koo khuraak-nirbhar roop seey manushyon mein 25 milligram aur 60 milligram (4 seey 10 milligram kii khuraak parr nyuntam seey koee avrodh naheen) parr fentanil-prerit ardhasutran koo avaruddh karane key liye paaya gayaa haye, yeh sujhaav dete hue kii dawa cumm seey cumm 25 milligram kii khuraak parr gambhir roop seey kabja curr letee haye aur roga kaa virodh karati haye lekin 10 milligram yaa usase cumm kii naheen. haalaanki, samanya swayamsevakon aur kokeen nirbharta key itihas vaale vishayon mein dawa key neuroendocrine prabhaavon kaa aaklan karane vaale ack aur halia adhyayan ney 10 milligram khuraak parr mamuli naitik virodh key saath susangat tippaniyon kii soochana dee. avasaad key pashu model mein, atticaprant mein anya avasaadarodhi jaise kii citalopram aur immipramine key sanyojan mein shaktishali sahakriyaatmak prabhavkarita paaee gaee haye.
positron utsarjan tomography imaging seey pataa chalaa kii 10 milligram kii ack khuraak key baad 2.5 ghante taka mastishk key corse lagbhag poori tarah seey dawa dwara santript they, joe 4 milligram seey 25 milligram khuraak kaa samarthan kartaa thaa jise naidaanik parikshanon mein atticaprent kaa pataa lagaaya jaa rhaa haye. 0.5 milligram khuraak key liye 35 pratishat aur 10 milligram khuraak key liye 94 pratishat adhibhog thaa. 24 ghante key baad, receptor adhibhog 0.5 milligram key liye 19 pratishat aur 25 milligram key liye 82 pratishat thaa. koee gambhir dushprabhaav naheen dekhaa gayaa, aur dekhe gaye sabhi dushprabhaav halke seey madhyam they aur unhein atticaprant key kaaran naheen maanaa gayaa thaa.
pharmacokinetics.
atticaprant kii maukhik jaiv upalabdhata 25 pratishat haye. dawa teji seey avashoshit hoe jaati haye, jisamen adhikatam sandrata prashaasan key 1 seey 2 ghante baad hoti haye. swasth vishayon mein iska unmoolan aadhaa jeevan 30 seey 40 ghante kaa hotaa haye. badhati khuraak key saath atticaprant kaa parisanchari star aanupaatik roop seey badhata haye. ack baar dainik khuraak key 6 seey 8 dinon key baad sthir-sthiti sandrata taka pahunch jaate hain. atticaprant koo rakt-mastishk baadha mein prajanan karane key liye dikhaaya gayaa haye.
itihas.
atticaprant koo mool roop seey ellie lilly dwara code naam laai-2456302 key tahat vikasit kiya gayaa thaa. yeh pahali baar 2010 yaa 2011 mein vaigyaanik saahitya mein dikhaai diyaa thaa. yaugik koo pahali baar 2009 mein patent kiya gayaa thaa.
farwari 2015 mein, sericor ink. ghoshana kii kii unhone lii-2456302 (nae vikasatmak code see. aar. see.-501 key tahat) koo vikasit karane aur vyaavsaayikaran karane key liye ellie lilly seey adhikaar praapt curr liye hain.
2016 taka, upchaar-pratirodhi avasaad key liye avasaadarodhi chikitsa key liye ack samvardhan key roop mein atticaprant charan II naidaanik parikshanon mein pahunch gayaa haye. bhaari dhumrapan karane vaalon mein atticaprent kaa doosara charan adhyayan 2016 kii shuruat mein shuru kiya gayaa thaa aur adhyayan key parinam 2016 key anta seey pahale apekshit they. atticaprent adhyayan mein nicotine kii nikasi key liye apane mukhya antim bindu koo puuraa karane mein whiffle rhaa.
agast 2017 mein, yeh ghoshana kii gaee thee kii sericor ney atticaprent key apane adhikaar jansen pharmaceuticals koo betch diye they. 2017 taka, jansen avasaad key upchaar key liye esketamine key saath bhee prayog curr rahey they.
shodh.
pramukh avasaadgrastata vikaar key alawa, atticaprent sharaab, kokeen upayog vikaar aur dhumrapan seey bachane key upchaar key liye vikas key adheen thaa. haalaanki, inn sanketon key liye vikas bund curr diyaa gayaa thaa.

