prasaar soochkaank

prasaar, tumour mein pehchaan aur sabse buniyaadi javic prakriyaon mein seey ack key roop mein, tumour kii pragati, chikitsa key liye pratikriya aur cancer rogi key jeevit rahane seey judaa huaa haye. natijatan, tumour prasaar soochkaank (yaa vikas ansh) key mulyankan kaa kaee thhos tumour aur hematological durbhavnaon koo chihnit karane mein naidaanik mahatva haye. isase jaanchkartaon koo tumour key namoonon mein prasaar soochkaank kaa mulyankan karane key liye vibhinn takneekon koo vikasit karane key liye prerit kiya haye. ack prasaar soochkaank key mulyankan mein sabse adhik upayog kii jaane vaali vidhiyon mein mitotic anukraman, thymidine-labeling soochkaank, bromodioxuridine parakh, koshika chakr key vibhinn charanon mein koshikaon key ansh kaa nirdhaaran aur koshika chakr seey judey protein kaa pratirakshaatmak rasayanik mulyankan shamil hain.
mitotic soochkaank (jise mitotic ginati bhee kahaa jaataa haye).
mitotic anukraman prasaar kaa aaklan karane kii sabse purani vidhi haye aur aich aind ee dagdar khandon parr ack halke sookshmadarshi key madhyam seey mitotic aankadon (mitosis seey gujarane vaali koshikaon) kii sankhya kii ginati karke nirdhaarit kiya jaataa haye. ise aamtaur parr prati sookshm kshetra koshikaon kii sankhya key roop mein vyakt kiya jaataa haye. mitotic charan mein koshikaon kii pehchaan koshika chakr key mitotic charan key dauran koshika mein unake gunasutron kii vishisht upasthiti seey kii jaati haye. aamtaur parr mitotic aankadon kii sankhya koo uchch shakti kshetron kii ack paribhaashit sankhya mein kull sankhya key roop mein vyakt kiya jaataa haye, jaise kii 10 uchch shakti kshetron mein 10 mitos. choonki drishti kshetra kaa kshetra vibhinn sookshmadarshi key beach kaafee bhinn hoe sakata haye, isaliye vibhinn adhyayanon key parinamon kii tulanaa karane key liye uchch shakti kshetron key sateek kshetra koo paribhaashit kiya jaanaa chaahiye. tadnusar, mitosis kii ginati kii mukhya samasyaon mein seey ack prajanan kshamata rahee haye. iss prakaar, punarutpaadak parinam praapt karane key liye maankeekrit karyapranali aur sakht protocol kii aavashyakta mahatvapurna haye. gahan shikshan-adharit algorithm kaa upayog karke swachaalit chhavi vishleshan koo rogvigyaani kii sahaayata karane aur iss tarah prajanan kshamata aur sateekta mein sudhaar karane key liye ack vachan upkaran prastaavit kiya gayaa haye.
thymidine-labeling soochkaank.
thymidine-labeling anukramanika kaa nirdhaaran thymidine key saath tumour koshikaon koo ushmaayan karane key baad autoradiograph kiye gaye khandon parr label kiye gaye tumour naabhik kii sankhya koo ginkar kiya jaataa haye. teji seey badhane vaali koshikaaen aasaani seey adhik radiolabeld thymidine koo update karati hain, joe autoradiograph film parr gahare dhabbe paida karati hain.
bromodioxuridine parakh.
ack bromodioxuridine parakh, joe thymidine-labeling anukraman key samaan haye, radiolabled bromodioxuridine key saath koshikaon koo ushmaayit karati haye, jise koshikaon key prasaar dwara adhik darr seey liya jaataa haye, aur phir koshikaon mein radiolabled bromodioxuridine key vitaran kii chhavi banaane key liye ack film kaa upayog kartaa haye.
aiss-charan ansh mulyankan.
pravaah koshika-maapan key madhyam seey dee. aine. aeye. histogram kaa mulyankan karane seey koshika chakr mein pratyek charan key bheetar koshikaon key anshon kaa anuman lagaaya jaa sakata haye. koshika naabhik ack dee. aine. aeye. bandhan daag seey dagdar hotey hain aur daag kii matra koo histogram seey maapa jaataa haye. vibhinn koshika chakr charanon charanon, aiss aur aur dibbon) key bheetar koshikaon key anshon kii ganana computerykrit koshika chakr vishleshan dwara histogram seey kii jaa sakati haye.
immunohystochemical mulyankan.
prasaar soochkaank nirdhaarit karane key liye prasaar seey sambandhit protein jaise kii-67 aur prasaar koshika paramanu pratijan kaa pratirakshaatmak rasayanik pataa lagaana ack aam taur parr upayog kii jaane vaali vidhi haye. kii-67 ack paramanu pratijan haye joe prasaar koshikaon mein vyakt kiya jaataa haye jise gunasutra 10 parr aim. key. aaee. 67 jeane dwara kodit kiya jaataa haye, aur koshika chakr key jee. aaee., aiss., jee. 2 aur aim charanon key dauran vyakt kiya jaataa haye. koshikaon koo phir ack kii-67 antibody seey daag diyaa jaataa haye, aur taba dagdar naabhik kii sankhya koo kull tumour koshikaon key pratishat key roop mein vyakt kiya jaataa haye. uchchatam label vaale kshetra mein cumm seey cumm 500 tumour koshikaon koo ginane kii sifarish kii jaati haye. kii-67 ank anya prasaar markers key saath nikatata seey sambandhit haye, aur kaee alag-alag prakaar key tumour key liye purvanumanatmak aur bhavishyasoochak moolya dikhaaya gayaa haye. isi tarah, pravardhan koshika paramanu pratijan (pee. see. aine. aeye.) koshika prasaar seey judaa ack protein haye joe pravardhan koshikaon mein viniyamit hotaa haye, jisase yeh pratirakshaatmak kshamata key liye ack aur upayogi pratijan bunn jaataa haye. yeh dee. aine. aeye. polymerase alfa seey judaa huaa haye, joe koshika chakr key sabhi charanon mein vyakt kiya jaataa haye. pee. see. aine. aeye. kii abhivyakti anya prasaar markers jaise mitotic ginati, aiss-charan ansh aur kii-67 dhundhlapan key saath bhee achchi tarah seey sambandhit haye.
prasaar soochkaank kii naidaanik bhoomika.
prasaar soochkaank koo chihnit karane key vibhinn tarikon ney tumour key naidaanik aur purvanumanatmak mulyankan donon mein bhoomika paaee haye. udaaharan key liye, mitotic koshikaon kii sankhya kaa upayog tumour koo vargeekrit karane key liye kiya jaataa haye. samanya taur parr, ack uchch prasaar soochkaank ghaatak aur uchch shreni key tumour kaa sujhaav detaa haye. thhos tumours mein, stun cancer parr prasaar soochkaank key naidaanik mahatva kaa vyaapak roop seey adhyayan kiya gayaa haye. kaee adhyayanon mein stun cancer mein mitotic ginati kaa purvanuman moolya bhee dikhaaya gayaa haye, jahaan mitotic koshikaon kii cumm ginati adhik anukool parinam key saath sambandhit haye, aur iss prakaar ise ootakiya shrenikaran pranali key hisse mein shamil kiya gayaa haye. kii-67 labeling soochkaank kaa bhee purvanumanatmak mahatva paaya gayaa haye, jahaan kaee naidaanik abhyaas dishaanirdeshon mein, nae nidan kiye gaye aakramak stun carcinoma mein kii-67 key mulyankan kii sifarish kii jaati haye. isake alawa, tumour prasaar soochkaank kaa upayog una rogiyon mein pranaaleegat chemotherapy kii pratikriya kaa anuman lagaane key liye kiya gayaa haye joe neoedjuvent pranaaleegat chikitsa praapt curr rahey hain, jahaan jinn rogiyon koo uchch tumour prasaar soochkaank vaale tumour hain, way una logon kii tulanaa mein pranaaleegat cytotoxic chikitsa key liye behtar pratikriya dete hain jinake paas cumm tumour prasaar soochkaank vaale tumour hain.

