auriothin

auriothin ack cytotoxic shikimet-polycatoid antibiotic kaa ack praakritik utpaad haye jiska aanvik sootra c22h23no6 haye. auriothin kaa utpaadan bacteria "streptomyces theolutus" dwara kiya jaataa haye joe antitumer, antifungal aur keetnashak gatividhiyon koo darshaata haye aur nae auriothin vyutpann antifungal aur antiproliferative hoe sakate hain. isake alawa, "streptomyces theolutus" seey ack nitro yaugik auriothin koo mitochondrial shwasan parisar mein hastakshep karke bean vivil key khilaf keetnashak gatividhi kaa sanket diyaa gayaa thaa. 
jaiv sanshleshan.
auriothin key jaiv sanshleshan key sambandh mein, jaiv sanshleshit maarg "chorismic acid" key saath shuru kiya jaayega. "pee"-nitrobenzoate "" pee ""-aminobenzoate seey ack "" aine ""-oxygeness dwara praapt kiya jaataa haye, jise "" orph "" dwara kootbaddh kiya jaataa haye.  orph" auriothin biosynthetic enzymon mein seey ack haye aur ise ack nonheim dyron oxygen key roop mein sandarbhit kiya jaataa haye joe "pee"-aminobenzoate koo "pee-" nitrobenzoate mein parivartit karane key liye jimmedaar haye. isake alawa, "orph" "pee"-aminobenzoate koo "pee"-nitrobenzoate mein badalane key liye dioxygen key dou samkakshon aur dou bahirjant electrons kaa upayog karke ack poorna chhah-electron okseekaran kii pratikriya koo utprerit kartaa haye. phir, teen prakaar key aaee polycatoid synthes (pee. key. aiss.), joe "aura, orb aur ork" dwara kootbaddh haye, aurothene key jaiv sanshleshan key liye ack starter ikai key roop mein "pee"-nitrobenzoate kaa upayog karke ack polycatoid shrinkhala utpann kartaa haye. iss bindu parr, punaravritti kii ack anu shrinkhala vistaar key dou kramik chakron koo utprerit kartaa haye, prakaar i polycatoid synthes (pee. key. aiss.) kii pratikriya mein hoga. vishesh roop seey, dou lagaatar chakron mein chaar baar methylmalonil-coa aur ack baar malonil-coa kaa hotaa haye joe prakaar aaee polycatoid synthes (pee. key. aiss.) key dauran hotaa haye. oh-methylan key baad ack methyltransferase dwara sakriya kiya jaataa haye, jise "aurie" dwara kootbaddh kiya jaataa haye, tetrahydrophuran ring gathan ack monoxygenase dwara utpaadit hotaa haye jise "aurah" dwara kootbaddh kiya jaataa haye. isaliye, antim utpaad, auriothin, "aurah" dwara kootbaddh monoxygenase key parinamswarup utpaadit hotaa haye. 

