
c9orf50

gunasutra 9 khula padhane kaa dhancha 50 ack protein haye jise manushyon mein "c9orf50" jeane dwara kootbaddh kiya jaataa haye. c9orf50 kaa ack anya gyaat upnaam haye, flj35803. manushyon mein jeane coding anukram 10,051 aadhar jode lamba haye, joe 1,624 kshaaron key ack mrna koo transcribe kartaa haye joe ack 431 amino acid protein koo kootbaddh kartaa haye.
jeane.
sthaan.
manushyon mein jeane nakaratmak strand parr 9q34.11 parr sthit haye aur coding anukram 8,552 aadhar jode lamba haye. maanav gunasutra 9 parr, jeane aadharon "chr 9:132,374,504-132,383,055" mein faila huaa haye joe c9orf50 key paas haye, joe kii nakaratmak strand parr c9orf50 seey seedhe pahale kaa jeane haye aur sakaratmak strand parr nTMt1 haye joe c9orf50 key aakar seey dogune seey adhik haye.]
protein.
see9orph50 protein kaa aanvik vajan 47,639 kilo dee haye aur isamen 431 emino acid hotey hain, jisamen anumaanit isoelectric bindu 10.38 see9orph50 protein mein pee. aff. aeye. aim.15737-duff4685 mein sanrakshit domen hotaa haye, jiska kaary kasheruki jeevon mein achchi tarah seey samajha aur sanrakshit naheen haye. protein 7 exon seey banaa hotaa haye.
isophorm.
see9orph50 mein 9 alag-alag splies isophorm (aiss. aaee.) aur 11 alag-alag transcript sanskaran (tv) hain, sabse aam isophorm 1 aur transcript sanskaran 1 haye.
domen.
protein kaa vishleshan poore key roop mein kiya jaa sakata haye aur saath hii 193 avasheshon key aine-terminaldoman, 103 avasheshon key dee. aff. 4685 aur 135 avasheshon key see-terminal domen sahit 3 bhaagon mein vibhajit kiya jaa sakata haye. poorna protein paaee aine. tii. dee., dee. yuu. aff. 4685 aur see. tii. dee. key ausat paaee key samaan haye. inn anubhagon mein seey aine. tii. dee. ney
uchchatam paaee aur mw lekin 431 mein seey 193 parr sabse adhik avashesh bhee hain.
rachana.
see9orph50 protein key sanrachanaatmak vishleshan seey manushyon key saapeksh aaee, aim, vaaee aur fikmani kii cumm matra aur aar, aur kr-aid kii uchch matra kaa pataa chalata haye. charge samoohon, uchch scoring charge yaa binaa charge kiye gaye khandon, charge runn, pattern, uchch scoring hydrophobic yaa transmembrane khandon key liye koee nishkarsh naheen hain. see key teen alag-alag advitiya sthaan 161,190 aur 342 kii sthiti mein paae gaye they. see9orph50 mein 3 doharaae jaane vaale sanrachanaaen bhee paaee jaati hain, pahala anukram pee. aar. ell. pee. _ key. ell. tii. 30 kii sthiti seey shuru hotaa haye aur phir 78 kii sthiti mein dohraya jaataa haye. ack aur doharaae jaane vaali sanrachana 99 aur 398 kii sthiti mein aiss. ell. pee. haye. 250 aur 303 parr antim doharaae jaane vaali sanrachana kaal seey bunny hoti haye.
tritiyak sanrachana.
aaee-tasser kaa upayog karke tritiyak see9orph50 protein sanrachanaaen paaee jaa sakati hain. iss upkaran key parinamswarup 5 drishya sanrachanaaen hain, jinamen seey dou uchchatam see score-3.25 aur-1.27 hain.
jeane star viniyaman.
pravartak.
see9orph50 key liye pravartak kshetra genomatics kaa upayog karate hue paaya gayaa thaa
jeane2promoter khoj injan. isake parinamswarup 6 pravartak kshetra paae gaye. jinamen seey kewal 2 pratilekh aur pinjare key tagg dwara samarthit they. sabse adhik samarthit pravartak kshetra 1,962 thikaanon mein faila huaa haye aur 945 pinjare key tagg key saath 8 orthologous loki mein seey 6 mein sanrakshit haye. pratilekhan praarambh sthal koo 118 pinjare tagg dwara samarthit 7 exone key saath ack pratilekh seey 1,503 parr sthit honey key liye nirdhaarit kiya gayaa thaa.
pratilekhan kaarak badhyakari sthal.
saikadon pratilekhan kaarak hain joe pravartak kshetra koo baandhane key liye anumaanit hain. pravartak kshetra pratilekhan kaarak talika inmein seey 20 koo ujagar karati haye.
pratilekh star viniyaman.
c9orf50 5 'yuu. tii. aar. antaraanvik aadhar yugmit sanrachana uchchatam delta jee key saath-323.4 kcal/mol haye. yeh 5 'utra kshetra key liye anumaanit sabse cumm oorjaa sanrachana haye. 3 'yuu. tii. aar. key liye, uchchatam dee. jee. haye-127.5 key. see. ell./moll joe darshaata haye kii yeh 5' yuu. tii. aar. key roop mein sthir naheen haye. 
ootak abhivyakti.
see9orph50 key rna-seik detta ney sabhi maanav proteins kii tulanaa mein adhikansh maanav ootakon mein nimn abhivyakti star, 25-50 th pratishat paaya haye. haalaanki, yeh vrishan, mastishk aur pittashay kii thaili mein sabse adhik vyakt kiya jaataa haye. c9orf50 protein abhivyakti c9orf50 rna abhivyakti seey adhik haye. jaba situ hybridisation detta kaa adhyayan kiya jaataa haye, tou mouse c9orf50 orthologue, prateek 1700001o22rik, kaa upayog beeta-actin key khilaf protein abhivyakti kii tulanaa karane key liye kiya jaataa thaa, joe sarvavyaapi roop seey vyakt kiya jaataa haye aur vishleshan mouse mastishk mein samaan abhivyakti pattern dikhaata haye. vikas key dauran, protein bhroon key charanon mein paaya jaa sakata haye.
upkoshika abhivyakti.
protein mukhya roop seey naabhik mein sthit haye aur mitochondria aur cytosol mein cumm paaya jaataa haye. 
orthologue.
see9orph50 key koee gyaat paralog naheen hain. see9orph50 key orthologue standhaariyon key adhikansh upvargon mein sanrakshit paae gaye hain, joe 159 million saal pahale alag kiye gaye infracless marsupialia key sabse door, oposum key saath hain. yeh jeane sarisripon, ubhaycharon, pakshiyon yaa standhaariyon seey pahale vikasit kissy anya jeev mein naheen paaya jaataa haye. standhaariyon kii ack soochi jisamen see9orph50 sanrakshit haye, neeche dikhaai gaee haye. 
vikas.
see9orph50 key cytochrome see, haemoglobin beeta aur fibrinogen alfa chain sahit anya samanya proteins kii tulanaa mein adhik teji seey vikasit honey kaa anuman haye. 
amino acid sanrakshan.
mahatvapurna amino acid una logon dwara chihnit kiye jaate hain joe sakht orthologue ekaadhik anukram sanrekhan key avalokan mein banaai gaee 100% sarvasammati rekha parr they. laal rung mein amino acid, duff4685 mein sanrakshit amino acid kaa pratinidhitva karate hain. 22 mein seey 14 atyadhik sanrakshit amino acid iss kshetra mein paae jaate hain. lucine see9orph50 protein key sabse sanrakshit sthaan parr haye.
utparivartan.
see9orph50 mein samanya roop aine. see. bee. aaee. snapgeneview key saath paae gaye they.

