
tetrahydrobiotic

tetrahydrobioterchitroptrictic (bh4, thb), jise sappropterin (inn) key roop mein bhee jaanaa jaataa haye, teen sugandhit emino acid hydroxylase enzymon kaa ack saha-kaarak haye, jiska upayog emino acid phenylanine key ksharan mein aur neurotransmitter serotonin (5-hydroxytryptine, 5-ht), melatonin, dopamine, norpinefrine (noradrenaline), epinephrine (adrenaline) key jaiv sanshleshan mein kiya jaataa haye, aur nitric oxide syntheses dwara nitric oxide (naheen) key utpaadan key liye ack saha-kaarak haye. rasayanik roop seey, isaki sanrachana ack (dihydropteridine reductage) cumm terridine vyutpann (quinonoid dihydrobiotic) kii haye.
chikitsa upayog.
tetrahydrobiotic "sappropterin dihydrochloride" (bh4 * 2hcl) key roop mein maukhik prashaasan key liye ack goli key roop mein upalabdh haye. ise disambar 2007 mein sanyukt raajya america mein ack goli key roop mein aur disambar 2013 mein ack pouder key roop mein upayog key liye anumodit kiya gayaa thaa. ise disambar 2008 mein europeeya sangh mein upayog key liye anumodit kiya gayaa thaa, aprail 2010 mein kanada aur julaai 2008 mein japan mein. ise brand naamon kuwan aur bioptain key tahat becha jaataa haye. ack rogi key ilaaj kii vishisht laagat prati varsh hoti haye. biomarine key paas cumm seey cumm 2024 taka kuwan key liye patent haye, lekin samaan dawa koo 2020 taka ack samanya sanskaran kaa utpaadan karane kaa adhikaar haye.
jee. tii. pee. cyclohydrolase aaee (jee. tii. pee. aich.) kii kamee, yaa 6-pyruvioletrehydropeters synthes (pee. tii. pee. aiss.) kii kamee key kaaran tetrahydrobiotic kii kamee mein sappropterin kaa sanket milata haye. bee. aich. 4 * 2aich. see. ell. koo aahar upaayon key saath-saath phenylcatonuria (pee. key. yuu.) mein upayog key liye aff. dee. aeye. anumodit kiya gayaa haye. haalaanki, pee. key. yuu. vaale adhikansh logon koo bee. aich. 4 * 2aich. see. ell. seey bahut cumm yaa koee laabh naheen hotaa haye.
pratikool prabhaav.
10 pratishat seey adhik logon mein dekhe jaane vaale sabse aam pratikool prabhaavon mein sirdard aur naak bahana yaa baadhit honah shamil haye. dast aur ulti bhee apekshaakrit aam hain, joe cumm seey cumm 1 pratishat logon mein dekhi jaati hain.
antahkriyaaen.
koee paraspar adhyayan naheen kiya gayaa haye. apane tantra key kaaran, tetrahydrobioterchitroptrictic methotrexet aur trimethoprim jaise dihydropholate reductage avrodhakon key saath baatchit curr sakata haye, aur nitroglycerine, molacidomin, minoxidil aur pee. dee. ee. 5 avarodhak jaisi koee-badhaane vaali davaaen naheen. levodopa key saath tetrahydrobiotic key sanyojan seey uttejana mein vriddhi hoe sakati haye.
kaary.
maanav jaiv rasayan mein tetrahydrobiotic kii kaee bhoomikaaen hain. pramukh amino acid jaise kii phenylanine, tyrosine aur tryptophan koo dopamine aur serotonin, pramukh monoemine neurotransmitter key agraduton mein parivartit karna haye. yeh ack saha-kaarak key roop mein kaam kartaa haye, ack utprerak key roop mein ack enzyme kii gatividhi key liye aavashyak haye, mukhya roop seey hydroxylase.
tryptophan hydroxylase key liye saha-kaarak.
tetrahydrobioterchitroptrictic ell-tryptophan (tii. aar. pee.) koo 5-hydroxytryptophane (5-aich. tii. pee.) mein badalane key liye tryptophan hydroxylase (tii. aff. aich.) key liye ack saha-kaarak haye.
phenylanine hydroxylase key liye saha-kaarak.
fenillanin hydroxylase (paah) ell-fenillanin (phey) koo ell-tyrosine (tyre) mein parivartit karane mein utprerit kartaa haye. isaliye, tetrahydrobiotic kii kamee seey ell-fenillanin kaa vishaakt nirmaan hoe sakata haye, joe phenylcatonuria mein dekhe jaane vaale gambhir tantrika sambandhi muddon key roop mein prakat hotaa haye.
tyrosine hydroxylase key liye saha-kaarak.
tyrosine hydroxylase (th) ell-tyrosine key ell-dopa (dopa) mein roopaantaran koo utprerit kartaa haye, joe dopamine key liye agradoot haye. dopamine ack mahatvapurna neurotransmitter haye, aur norpinefrine aur epinephrine kaa agradoot haye. iss prakaar, bee. aich. 4 kii kamee seey dopamine, norpenephrine aur epinephrine kii pranaaleegat kamee hoe sakati haye. vaastav mein, jee. tii. pee. aich. seey sambandhit bee. aich. 4 kii kamee key parinamswarup honey vaali praathamik sthitiyon mein seey ack dopamine-uttardaayi dystonia haye; vartamaan mein, iss sthiti kaa ilaaj aamtaur parr carbidopa/levodopa key saath kiya jaataa haye, joe seedhe mastishk key bheetar dopamine key star koo bahaal kartaa haye.
nitric oxide synthes key liye saha-kaarak.
nitric oxide synthes (aine. oh. aiss.) ell-arginine (ell-aar. jee.) key ack gwanidino nitrogen key nitric oxide (naheen) mein roopaantaran koo utprerit kartaa haye. anya cheejon key alawa, nitric oxide nasbandi mein shamil hotaa haye, joe vyavasthit rakt pravaah mein sudhaar kartaa haye. iss enzymatic prakriya mein bee. aich. 4 kii bhoomika itani mahatvapurna haye kii kuchh shodh bee. aich. 4 kii kamee kii or ishara karate hain-aur iss prakaar, nitric oxide kii-neurovascular disfunction kaa ack mukhya kaaran honey key roop mein joe parisancharan seey sambandhit beemariyon kii pehchaan haye jaise kii madhumeh.
eather lipid oxidase key liye saha-kaarak.
eather lipid oxidase (alkilglycerol monoxyginase, aeye. jee. aim. oh.) 1-alkill-aiss. aine.-glycerol koo 1-hydroxialkil-aiss. aine.-glycerol mein parivartit karane mein utprerit kartaa haye.
itihas.
tetrahydrobiotic kii khoj ack enzymatic coffector key roop mein bhoomika nibhaane key liye kii gaee thee. tetrahydrobiotic kaa upayog karane vaalaa pahala enzyme fenilelnin hydroxylase (paah) haye.
jaiv sanshleshan aur punarchakran.
tetrahydrobioterchitroptrictic koo gwanosin trifosphate (jee. tii. pee.) seey jee. tii. pee. cyclohydrolase aaee (jee. tii. pee. aich.), 6-pyruvioltetronhydrope synthes (pee. tii. pee. aiss.) aur sapiapterin reductase (aiss. aar.) enzymon dwara madhyasthata kii jaane vaali teen rasayanik pratikriyaon dwara jaivasanshleshit kiya jaataa haye.
bee. aich. 4 koo ack yaa dou electron pratikriyaon dwara aukseekrit kiya jaa sakata haye, jisase kramshah bee. aich. 4 yaa bee. aich. 3 radical aur bee. aich. 2 utpann hotaa haye. shodh seey pataa chalata haye kii ascorbic acid (jise escorbet yaa vitamin see key roop mein bhee jaanaa jaataa haye) bh3 radical koo bh4 mein cumm curr sakata haye, bh3 radical koo anya mukt radical (superoxide aur vishesh roop seey peroxintrite) key saath pratikriya karane seey roque sakata haye. iss punarchakran prakriya key binaa, endothelial nitric oxide synthes (anos) enzyme kaa uncoupling aur vasodilator nitric oxide kii cumm jaiv upalabdhata hoti haye, jisase endothelial disfunction kaa ack roop banata haye. ascorbic acid koo iss prakriya key dauran nirjalit acid mein aukseekrit kiya jaataa haye, halanki ise ascorbic acid mein vaapas punarnaveenikaran kiya jaa sakata haye.
folic acid aur isake chayapachaya bee. aich. 4 aur aine. oh. aiss. yugman key punarchakran mein vishesh roop seey mahatvapurna prateet hotey hain.
shodh.
pee. key. yuu. adhyayanon key alawa, tetrahydrobioterchitroptrictic ney tetrahydrobioterchitroptrictic kii kamee key parinamswarup sthitiyon koo hull karane key anya tarikon kaa adhyayan karane vaale naidaanik parikshanon mein bhaag liya haye. inmein autism, avasaad, aeye. dee. aich. dee., uchch raktchaap, endothelial disfunction aur purani gurde kii bimari shamil hain. prayogaatmak adhyayanon seey pataa chalata haye kii tetrahydrobiotericatic hriday roga kii sthiti mein nitric oxide key cumm utpaadan koo niyantrit kartaa haye, aur soojan aur chot kii pratikriya mein yogdan detaa haye, udaaharan key liye tantrika chot key kaaran dard mein. pee. key. yuu. rogiyon key 2015 key biomarine-vitt poshit adhyayan mein paaya gayaa kii joe loga tetrahydrobiotericatic kaa jawab dete they, unamen bhee aeye. dee. aich. dee. lakshnon mein kamee dikhaai dee.
avasaad.
manochikitsa mein, tetrahydrobiotercopete koo avasaad key pathophysiology mein shamil honey kii parikalpana kii gaee haye, halanki aaj taka saboot anirnaayak hain.
autism.
1997 mein, autism key lakshnon seey raahat dene parr tetrahydrobioterchitroptrictic (bee. aich. 4) kii prabhavkarita parr ack chhota saa pilot adhyayan prakaashit kiya gayaa thaa, jisane nishkarsh nikala kii yeh "autism vaale bachchon key upsamooh key liye upayogi hoe sakata haye" aur double-blind parikshanon kii aavashyakta haye, jaisa kii pareekshan hain joe lambe samay taka parinamon koo maapate hain. 2010 mein, fraay aur anya. ack pepper prakaashit kiya jisane nishkarsh nikala kii yeh surakshit thaa, aur yeh bhee nott kiya kii "kaee naidaanik parikshanon ney sujhaav diyaa haye kii bee. aich. 4 key saath upchaar kuchh vyaktiyon mein lakshan vigyaan mein sudhaar kartaa haye."
hriday roga.
choonki nitric oxide kaa utpaadan raktchaap aur rakt pravaah key viniyaman mein mahatvapurna haye, jisase hriday rogon mein mahatvapurna bhoomika nibhaati haye, isaliye tetrahydrobiotic ack sambhaavit chikitsiya lakshya haye. rakt vaahikaon key endothelial koshika astar mein, endothelial nitric oxide synthes tetrahydrobiotic kii upalabdhata parr nirbhar haye. biosynthetic enzyme jee. tii. pee. aich. key star koo badhaakar endothelial koshikaon mein tetrahydrobiotericatic koo badhaana, madhumeh, atherosclerosis aur hypoxic pulmonary hypertension jaise roga raajyon key prayogaatmak model mein endothelial nitric oxide synthes kaary koo banaae rakh sakata haye. haalaanki, maukhik tetrahydrobiotic key saath maujooda coronary dhamani roga vaale logon kaa upchaar tetrahydrobiotic key okseekaran dwara nishkriya roop, dihydrobiotic key okseekaran dwara seemit haye, jisase samvahani kaary parr bahut cumm laabh hotaa haye.
prasavpurv hypoxia mein neuroprotection.
tetrahydrobiotic kii kamee hypoxic mastishk mein hoti haye aur vishaakt padaarth key utpaadan kii or leey jaati haye. choohon mein poorv naidaanik adhyayanon seey pataa chalata haye kii maukhik tetrahydrobiotic therapy key saath upchaar vikaasheel mastishk parr hypoxia key vishaakt prabhaavon koo cumm kartaa haye, vishesh roop seey hypoxic jaanvaron mein safed padaarth key vikas mein sudhaar kartaa haye.
kramaadeshit koshika mrityu.
jee. tii. pee. aich. (jee. see. aich. 1) aur tetrahydrobiotic kii koshika model mein vishaakt lipid peroxide key gathan koo seemit karke pheroptosis dwara koshika mrityu seey bachaane mein ack maadhyamik bhoomika paaee gaee. tetrahydrobiotic ack shaktishali, visarjit antioxidant key roop mein kaary kartaa haye joe oxidative tanaav kaa pratirodh kartaa haye aur angiogenesis koo badhaava dene key madhyam seey cancer koshika koo jeevit rahane mein saksham banaata haye.