
enterobactin

enterobactin (jise enterochellin key roop mein bhee jaanaa jaataa haye) ack uchch aatmiyata vaalaa ciderophore haye joe sookshmajeev pranaliyon key liye loha praapt kartaa haye. yeh mukhya roop seey graam-negative bacteria mein paaya jaataa haye, jaise kii "escarichia kolai" aur "salmonella typhimurium".
enterobactin sabse majboot cydorophore haye, joe ferric aayan (fe3 +) key saath bandhan key saath gyaat haye, joe kii k = 1052 m−1 haye. yeh moolya kuchh synthetic dhaatu cheeletaron, jaise kii edda (kf, fe3 + ~ 1025 aim−1) seey bhee kaafee badaa haye. apani uchch aatmiyata key kaaran, enterobactin una vatavaranon mein bhee chealet karane mein saksham haye jahaan ferric aayan kii sandrata bahut cumm hoti haye, jaise kii jeevit jeevon key bheetar. rogjanak bacteria iss tantra kaa upayog karke anya jeevit jeevon seey loha churaa sakate hain, bhale hii mukt lohe kii vishaaktata key kaaran lohe kii sandrata behad cumm rakhee jaati haye.
sanrachana aur jaiv sanshleshan.
choreosmic acid, ack sugandhit amino acid agradoot, enzymon, aint, antub aur antuck kii ack shrinkhala dwara 2,3-dihydroxybenzoic acid (dhb) mein parivartit hoe jaataa haye. dee. aich. bee. seey ell-serine key ack amide linkage koo phir aine. tii. dee., aine. tii. ee., aine. tii. aff. aur aine. tii. bee. dwara utprerit kiya jaataa haye. [beach mein sanshleshan chhavi sanrachana dihydroxybenzoic honey chaahiye, galat tareeke seey chorismic acid dikhaaya gayaa haye]. dee. aich. bee.-sair key teen anu antar-aanvik chakran seey gujarate hain, jisase enterobactin praapt hotaa haye. halanki syrine avasheshon kii chirality key kaaran kaee stereoisomers sambhav hain, kewal δ-cis isomer chayapachaya roop seey sakriya haye. dhaatu enterobactin parisar kii pahali tri-ayami sanrachana koo vanadium (iv) parisar key roop mein nirdhaarit kiya gayaa thaa. halanki ferric enterobactin lambe samay taka kristalikaran seey butch gayaa thaa, isaki nishchit tri-ayami sanrachana antatah resmick chrystallography kaa upayog karke praapt kii gaee thee, jisamen ferric enterobactin key 1:1 mishran key chrystal aur isaki darpan chhavi (ferric anantioenterobactin) koo aiks-ray chrystallography dwara vikasit aur vishleshan kiya gayaa thaa.
tantra.
jeevaanu koshikaon mein lohe kii kamee seey baahya koshikiya vatavaran mein enterobactin kaa sraav hotaa haye, jisase ack samanvaya jatil "feint" kaa nirmaan hotaa haye jisamen ferric aayan koo enterobactin key sanyugmit aadhar mein chealet kiya jaataa haye. escarichia kolai" mein, jeevaanu baahari jhilli mein fepa taba jeevaanu periplasm mein feint key pravesh kii anumati detaa haye. aff. ee. pee. bee., see., dee. aur jee. sabhi ack aeye. tii. pee.-binding casset transporter key madhyam seey aantarik jhilli key madhyam seey feint key parivahan mein bhaag lete hain.
enterobactin key atyadhik lohe key bandhan key kaaran, lohe koo hataane key liye ferrienterobactin esteres key saath feat koo alag karna aavashyak haye. iss ksharan seey teen 2,3-dihydroxybenzyl-ell-serine ikaaiyaan utpann hoti hain. iss daraar key saath iron (aff. ee. 3 + seey aff. ee. 2 +) mein kamee hoti haye, lekin koee feint bacterial reductage enzyme kii pehchaan naheen kii gaee haye, aur iss prakriya key liye tantra abhee bhee spasht naheen haye. phee3 +/phee2 +-enterobactin complexes key liye kamee kshamata ph parr nirbhar haye aur ph6 parr − 0.57 vee (banaam aine. aich. ee.) seey laker ph. 7.4 parr − 0.79 vee seey laker 10.4 seey adhik ph maanon parr − 0.99 taka bhinn hoti haye.
itihas.
1970 mein gibson aur neeland samoohon dwara enterobactin kii khoj kii gaee thee. inn praarambhik adhyayanon ney sanrachana aur 2,3-dihydroxybenzoic acid key saath isake sambandh koo sthaapit kiya.

