
immunotoxin

immunotoxin ack kritrim protein haye jisamen ack vishaakt padaarth seey judaa ack lakshit bhaag hotaa haye. jaba protein usa koshika seey judataa haye, tou ise endocytosis key madhyam seey liya jaataa haye, aur vish koshika koo maar detaa haye. inca upayog kuchh prakaar key cancer aur kuchh viral sankramanon key ilaaj key liye kiya jaataa haye.
design.
yeye chimerick protein aamtaur parr ack sanshodhit antibody yaa antibody tukade seey baney hotey hain, joe ack vish key tukade seey judey hotey hain. lakshit bhaag ack antibody key fab bhaag seey banaa hotaa haye joe ack vishisht koshika prakaar koo lakshit kartaa haye. vish aamtaur parr ack aib toxin hotaa haye, ack jeevaanu yaa paudhe key protein seey praapt ack cytotoxic protein, jisase praakritik bandhan kshetra koo hataa diyaa gayaa haye taaki fv vish koo lakshit koshika parr pratijan taka leey jaae.
kabhi-kabhi ack vish aur ack vikas kaarak vaale punarsanyojit sanlayan protein koo punarsanyojit pratirakshaatmak vish key roop mein bhee jaanaa jaataa haye, halanki unamen ack pratidravya tukada naheen hotaa haye. iss baad key prakaar key protein kaa ack adhik vishisht naam recombinant fusion toxin haye.
utpaadan.
way mool roop seey ack rasayanik linker kaa upayog karke vish seey antibody koo jodkar utpaadit kiye gaye they. way abb recombinant dna takneekon kaa upayog karke banaae jaate hain, jaise "ee" bacteria mein utpaadit hotey hain. kolai koo recombinant immunotoxin kahaa jaataa haye.
kaary.
antibody (yaa anya lakshit bhaag) lakshit koshika parr ack pratijan seey judati haye aur vish taba koshika mein pravesh karati haye aur maar detee haye.
naidaanik anuprayog.
apavartak kesh koshika leukemia key rogiyon key ilaaj mein sabse achchi naidaanik safalata hassil kii gaee haye. inn rogiyon kaa upchaar recombinant immunotoxin key saath kiya gayaa thaa joe inn leukemic koshikaon parr cd22 koshika satah receptor koo lakshit kartaa haye. dou aniyantrit naidaanik adhyayanon mein, lagbhag aadhe pratibhagiyon ney bee. ell. 22 upchaar key baad poori pratikriya praapt kii. iss upchaar koo thodaa sanshodhit sanskaran, aich. aeye. 22 dwara pratisthaapit kiya gayaa haye.
resimmune key ack halia charan I adhyayan mein twachiya tii koshika lymphoma vaale nau rogiyon key upsamooh mein 89 pratishat pratikriya darr paaee gaee. yeh upsamooh 50 seey cumm key aim. aiss. doubleu. aeye. tii. ankon key saath charan aaee. bee. aaee. bee. thaa. poorna pratikriya darr 50 pratishat thee (jinamen seey dou 72 maheene kii avadhi seey adhik hain aur upchaar kaa pratinidhitva curr sakate hain).