
macroprolectin

macroprolectin, jise paaramparik roop seey bigg-bigg prolactin key roop mein bhee jaanaa jaataa haye, prolactin kaa ack shaaririk roop seey nishkriya roop haye joe logon key ack chhote seey anupaat mein paaya jaataa haye. iss prakaar kaa prolactin rakt parikshanon parr prolactin key roop mein dikhaai detaa haye, jisase prolactin kaa galat roop seey uchch parinam hotaa haye. isase kuchh logon mein hyperprolactinemia kaa galat nidan hoe sakata haye, vishesh roop seey una logon mein jinamen baanjhapan yaa masik dharm kii samasyaaen jaise anya lakshan hain.
"macroprolactin" aamtaur parr prolactin aur igg (aamtaur parr igg4) kaa ack jatil haye, joe lagbhag 150 kda key aanvik vajan koo pradarshit kartaa haye (joe isaliye mool anu seey 6-7 gunaa adhik haye). atyadhik glycosylated prolactin monomers yaa prolactin-iga complexes (i.ee. gair-igg-prakaar kaa macroprolectin) isi tarah kaary kartaa haye aur "macroprolectin" key roop mein bhee ginaa jaataa haye. 
hyperprolactinamia key rogiyon mein, prolactin isophorm key seeram pattern mein aamtaur parr 60%-90% monomeric prolactin, 15%-30% bigg-prolactin (40-60 kda: aamtaur parr prolactin diamer yaa bigg-bigg degradation utpaad) aur 0%-10% bigg-bigg prolactin (> 100 kda) shamil hotey hain. macroprolectinemia kii sthiti koo isaliye pradhaantaa (i.ee. > 30%-60%) aanvik vajan> 100 kda key saath parisanchari prolactin isophorm kaa.
polyethylene glycol jaise kuchh rasayan hain, jinhen sandigdh namoone seey macroprolectin koo hataane key liye jodaa jaa sakata haye. isake baad namoone kaa phir seey vishleshan kiya jaa sakata haye kii kyaa prolactin kaa star abhee bhee adhik haye. macroprolectin kaa nidan karane key liye swarn maanak pareekshan jail-nispandan chromatography haye.

