surfactant protein aeye1

surfactant protein aeye1 aeye1, jise pulmonary surfactant-associated protein aeye1 (psp-aeye) key roop mein bhee jaanaa jaataa haye, ack protein haye jise manushyon mein mein jeane dwara encode kiya jaataa haye.
saransh.
सारांश। koo mukhya roop seey fefadon mein type II vayukoshiya koshikaon mein sanshleshit kiya jaataa haye, joe fuffusiya surfactant key roop mein jaane jaane vaale lipid aur protein key ack jatil bhaag key roop mein hotaa haye. iss parisar kaa kaary vayukosh mein satah key tanaav koo cumm karna aur samaapti key dauran unake patan koo rokna haye. surfactant kaa protein ghatak janmajaat pratiraksha pratikriya aur soojan prakriyaon key modulan mein madad kartaa haye.
aiss. pee.-aeye. 1, see-prakaar key lectin key upa-parivaar kaa sadasya haye jise collectin kahaa jaataa haye. aiss. pee.-aeye. 2 key saath, way fuffusiya surfactant key sabse prachur matra mein protein hain. aiss. pee.-aeye. 1 kaee sookshmajeevon kii satah mein paae jaane vaale carbohydrate seey judataa haye aur shwasan rogjanakon key khilaf raksha mein madad kartaa haye.
surfactant homeostasis samay seey pahale paida hue shishu mein saans lene (aur iss prakaar jeevit rahane) key liye mahatvapurna haye, lekin fefadon key swaasthya aur poore jeevan mein samanya fefadon key kaary koo banaae rakhane key liye bhee mahatvapurna haye. surfactant kii matra yaa sanrachana mein parivartan isake kaary koo badal sakate hain aur shwasan rogon seey judey hotey hain.
aiss. aff. tii. pee. aeye. 1 abhivyakti.
fefda aiss. aff. tii. pee. aeye. 1 sanshleshan kaa mukhya sthal haye, lekin aiss. aff. tii. pee. aeye. 1 aim. aar. aine. aeye. abhivyakti kaa pataa shwasanali, prostate, agnyashay, thymus, brihadantra, aankh, laar granthi aur anya ootakon mein bhee lagaa haye. surfactant protein aeye key liye vishisht monoclonal antibody kaa upayog karke, protein kaa pataa fefadon key vayukoshiya prakaar II pneumocytes, club koshikaon aur vayukoshiya macrophage mein lagaaya jaa sakata haye, lekin koee atirikt-fuffusiya spu-aeye pratiraksha naheen dekhi gaee thee.
jeane.
aiss. aff. tii. pee. aeye. 1 gunasutra 10 kii lambi bhuja "kyu" mein sthit haye, joe aiss. aff. tii. pee. aeye. 2 key karib haye. aiss. aff. tii. pee. aeye. 1 jeane lambai mein 4505 aadhar jode hain, aur 94 pratishat aiss. aff. tii. pee. aeye. 2 key samaan haye. aiss. aff. tii. pee. aeye. 1 kii sanrachana mein chaar coding exon (aaee-aaee. vee.), aur kaee 5 'yuu. tii. aar. untranslated exon (aeye, bee, bee', see ', dee', dee ') hotey hain. aiss. aff. tii. pee. aeye. 1 kii abhivyakti koo protein, chhote aar. aine. aeye. (microrna), glucocorticoid aadi sahit cellular karakon dwara niyantrit kiya jaataa haye. isaki abhivyakti bhee epigenetic aur paryavaraniya karakon dwara viniyamit haye.
coding kshetra mein aiss. aff. tii. pee. aeye. 1 jeane anukram mein antar vyaktiyon key beach aiss. pee.-aeye. aanuvanshik roop yaa haplotype nirdhaarit kartaa haye. aabaadi mein 30 seey adhik prakaron kii pehchaan kii gaee haye aur aiss. aff. tii. pee. aeye. 1 (aur aiss. aff. tii. pee. aeye. 2) key liye visheshta haye. aiss. aff. tii. pee. aeye. 1 prakaar emino acid 19,50,62,133 aur 219 key coden mein nucleotide parivartan key parinamswarup hotey hain. inmein seey dou aiss. pee.-aeye. 1 protein anukram (emino acid 62 aur 133) koo sanshodhit naheen karate hain, jabaki baaki emino acid pratisthaapan (emino acid 19,50,133 aur 219) mein parinam dete hain. chaar aiss. pee.-aeye. 1 prakaar (6aeye, 6aeye2,6aeye3,6aeye4) samanya aabaadi mein adhik aavritti mein hain. sabse adhik paaya jaane vaalaa sanskaran 6a2 haye.
sanrachana.
surfactant protein aeye (aiss. pee.-aeye) 248 emino acid kaa ack protein haye joe aamtaur parr badee oligomeric sanrachanaon mein paaya jaataa haye. paripakva aiss. pee.-aeye. 1 monomer ack 35key. dee. aeye. protein haye joe coding kshetra mein chaar emino acid mein aiss. pee.-aeye. 2 seey alag hotaa haye. aiss. pee.-aeye. 1 monomers kii sanrachana mein chaar kshetra hotey hainh ack aine-terminal, ack collegen jaisa kshetra, ack gardan kshetra aur ack carbohydrate pehchaan kshetra. see-terminal carbohydrate recognition domen (see. aar. dee.) vibhinn prakaar key sookshmajeevon aur anuon koo baandhane kii anumati detaa haye.
amino acid antar joe sp-a1 aur sp-a2 jeane key beach aur unake sambandhit roopon key beach antar karate hain, collegen jaise kshetra mein sthit hotey hain. aiss. aff. tii. pee. aeye. 1 prakaron key beach antar karane vaale emino acid antar carbohydrate pehchaan aur collegen jaise kshetra donon mein sthit hain.
105kda key trimeric sanrachanaatmak upa-ikaaiyon mein anya sp-a1 yaa sp-a2 monomers key saath sp-a1 monomers samooh. inmein seey chhah sanrachanaaen 630 kda sanrachanaon mein samooh hain joe foolon key guldaste seey milati-julati hain. inn alpjanakon mein kull athaarah sp-a1 aur/yaa sp-a2 monomers hotey hain.
janmajaat pratiraksha.
janmajaat pratiraksha mein aiss. aff. tii. pee. aeye. 1 kii bhoomika kaa vyaapak roop seey adhyayan kiya gayaa haye. aiss. pee.-aeye. mein bacteria, kavak, virus aur anya gair-javic pratijanon koo baandhane aur ektreekrit karane kii kshamata haye. kuchh kaary jinake dwara aiss. aff. tii. pee. aeye. 1 aur aiss. aff. tii. pee. aeye. 2 donon janmajaat pratiraksha mein yogdan karate hain, unamen shamil hainh
vayu pradooshan jaise paryavaraniya upman, aur ozon aur kann padaarth kii uchch sandrata key sampark mein aaney seey aiss. aff. tii. pee. aeye. 1 abhivyakti key epigenetic viniyaman koo shamil karane vaale tantron key madhyam seey aiss. pee.-aeye. abhivyakti aur kaary koo prabhaavit curr sakate hain.
naidaanik mahatva.
aiss. pee.-aeye. staron mein kamee samay seey pahale paida honey vaale shishuon mein shishu shwasan sankat syndrome seey judee hoti haye, jisamen surfactant utpaadan kii vikasatmak aparyaptata aur fefadon mein sanrachanaatmak aparipakvata hoti haye.
aiss. aff. tii. pee. aeye. 1 aanuvanshik roop, snaps, haplotype aur anya aanuvanshik vividhataaen navjat shishuon, bachchon aur vayaskon kii kaee aabaadi mein teevra aur purani fefadon kii bimari seey judee hui hain. aiss. aff. tii. pee. aeye. 1 mein aanuvanshik bhinnataaen idiopathic pulmonary fibrosis kii samvedansheelta seey judee hui hain, ack fefde kii bimari joe saans kii takleef, fuffusiya ghuspaith aur soojan kii visheshta haye jisake parinamswarup fefadon key ootak key baad key nishan key saath teevra fefadon kii kshati hoti haye. aiss. aff. tii. pee. aeye. 1 mein aanuvanshik bhinnataaen bhee samay seey pahale shishuon mein shwasan sankat syndrome kii samvedansheelta kaa kaaran hain, ack fefde kii bimari joe gais kii kamee, diffuse atellectasis, uchch-pargamyata vaale fefadon kii shoth aur fibrin-samriddh vayukoshiya jamaa dwara visheshta haye.
kull aiss. pee.-aeye. key liye aiss. pee.-aeye. 1 kaa anupaat fefadon kii bimari (ee.jee. asthama, cystic fibrosis) aur umr badhana. fefadon key cancer key ootakon mein aiss. aff. tii. pee. aeye. 1 pravartak anukramon kaa methylation bhee paaya gayaa haye.
jeane viniyaman.
aiss. aff. tii. pee. aeye. 1 kii jeane abhivyakti koo vibhinn staron parr viniyamit kiya jaataa haye jisamen jeane pratilekhan, anurekhan key baad prasanskaran, sthirata aur paripakva aim. aar. aine. aeye. kaa anuvaad shamil haye. maanav surfactant protein aeye aim. aar. aine. aeye. kii mahatvapurna visheshtaon mein seey ack yeh haye kii unamen ack charr paanch pramukh anuvaadit kshetra (5 'yuu. tii. aar.) haye joe exon aeye, bee, see aur dee key vibhajan bhinnata seey utpann hotaa haye. maanav aiss. aff. tii. pee. aeye. 1 aur aiss. aff. tii. pee. aeye. 2 5 'utter key cumm seey cumm 10 roopon kii pehchaan kii gaee haye joe nucleotide anukram, lambai aur saapeksh matra mein bhinn hain. vishisht aiss. aff. tii. pee. aeye. 1 yaa aiss. aff. tii. pee. aeye. 2 5 'utter kii bhee visheshta haye. kuchh aiss. aff. tii. pee. aeye. 1 vishisht 5 'utter mein exon bee' yaa see shamil hain. inn dou exone mein upstream augs (yuu. aeye. jee.) hotey hain joe sambhaavit roop seey anuvaad kii shuruat key liye saiton key roop mein kaary curr sakate hain (eukariotic anuvaad dekhein), joe protein anuvaad aur aiss. aff. tii. pee. aeye. 1 saapeksh samagri koo prabhaavit karate hain. adhikansh aiss. aff. tii. pee. aeye. 1 pratilekhon mein exon bee kii kamee hoti haye, joe pratilekhan aur anuvaad vriddhi mein shamil ack anukram haye, joe aiss. aff. tii. pee. aeye. 1 aur aiss. aff. tii. pee. aeye. 2 abhivyakti key antar viniyaman kaa sanket detaa haye. vigyaapan 'roop aiss. aff. tii. pee. aeye. 1 pratilekhon (81 pratishat) mein sabse adhik pratinidhitva kartaa haye, aur prayogaatmak kaam seey pataa chalaa haye kii yeh anukram aim. aar. aine. aeye. koo sthir curr sakata haye aur anuvaad koo badhaa sakata haye, lekin iss viniyaman mein shamil tantra abhee bhee jaanch key dayare mein hain. jabaki 5 'utter mein antar pratilekhan aur anuvaad donon koo viniyamit karane key liye dikhaae gaye hain, hain roopon key 3' utter mein bahuroopata mukhya roop seey dikhaai gaee haye, vibhinn roop seey anuvaad dakshata koo prabhaavit karati haye joe tantra key madhyam seey protein aur/yaa [micrornas] key bandhan koo shamil karati haye. aiss. aff. tii. pee. aeye. 1 aur aiss. aff. tii. pee. aeye. 2 protein key star parr iss viniyaman kaa prabhaav fefadon kii bimari kii samvedansheelta mein vyaktigat antar mein yogdan curr sakata haye.
paryavaraniya upman aur pradooshak bhee aiss. aff. tii. pee. aeye. 1 abhivyakti koo prabhaavit karate hain. fefadon kii koshikaon key kann padaarth key sampark mein aaney seey aiss. aff. tii. pee. aeye. 1 pratilekhon key 5 'yuu. tii. aar. exone key vibhajan koo prabhaavit kartaa haye. pradooshak aur viral sankraman bhee aiss. aff. tii. pee. aeye. 1 anuvaad tantra koo prabhaavit karate hain (eukariotic anuvaad, anuvaad (jeev vigyaan) dekhein).

