billastin

billastin ack antihistamine dawa haye jiska upayog pittashay (eurticaria), allergy rhinitis aur allergy key kaaran honey vaali aankho mein soojan (allergy netrashleshmashoth) key ilaaj key liye kiya jaataa haye. yeh doosari peedhi kaa antihistamine haye aur inn allergy pratikriyaon koo rokte hue histamine histamine receptor koo chuninda roop seey rokkar prabhaav daaltaa haye. billastin kii prabhavsheelta saterigin, phexophenadine aur desloratdine key samaan hoti haye.
talika mein dikhaae gaye brand naamon key tahat kaee dawa companiyon dwara billastin becha jaataa haye. european union mein allergy netrashleshmashoth aur eurticaria key lakshanaatmak upchaar key liye billastin koo manjuri dee gaee haye. yeh sanyukt raajya america mein kissy bhee upayog key liye anumodit naheen haye. 
saakshyon seey pataa chalaa haye kii billastin twacha aur allergy pratikriyaon key aankho key lakshnon key ilaaj mein prabhaavi haye, jisase rogi key jeevan kii gunavatta mein sudhaar hotaa haye. billastin allergy aur naidaanik pratirakshan vigyaan (eaci) kii europeeya akadami aur allergy nasikashoth aur asthama (eriya) pahal key prabhaav dwara prakaashit allergy nasikashoth key upchaar maandandon koo puuraa kartaa haye.
chikitsa upayog.
allergies rhinoconjuctivitis.
allergies nasikashoth (aeye. aar.) aur eurticaria mein billastin kii naidaanik prabhavkarita kaa 10 naidaanik parikshanon mein aaklan kiya gayaa haye jisamen 4,600 seey adhik rogi shamil they. una sabhi ney placebo key saath billastin aur doosari peedhi key antihistamine kii pushti prabhavkarita (sakriya tulnitra) key saath tulanaa kii.
allergies nasikashoth.
saar parr adhyayan dohare-andhe, placebo-niyantrit, samanantar-samooh they jisamen adhyayan kii shuruat mein 12 varsh seey adhik ayu key purush aur mahila rogiyon koo rogsoochak roga key saath shamil kiya gayaa thaa. naak key lakshnon (chheenk, nasika, naak kii khujali aur bheed) kaa upchaar seey pahale aur upchaar avadhi key dauran dainik aadhar parr mulyankan kiya gayaa thaa. gair-naak key lakshnon (aankho mein khujali, aankho mein paani, kaana mein khujali aur taaloo) kaa bhee 0-3 paimaane key anusaar mulyankan kiya gayaa thaa, taaki kull lakshan score (tss) aur anya sambandhit mapdand pratyek rogi aur upchaar samooh mein saar key dainik vikas koo spasht roop seey pratibimbit curr sakein. jeevan kii gunavatta aur asuvidha jaise maapdandon kaa bhee mulyankan kiya gayaa, aur usee tarah aeye. ee. key prakaar aur aavritti, sahansheelata aur upchaar kii samanya suraksha darj kii gaee. iss saar adhyayan mein 14 dinon key dauran dainik maukhik prashaasan billastin kii prabhavkarita saterigin aur desloratadine key prashaasan key samaan saabit hoti haye.
eurticaria.
ack sameeksha lekh ney parikshanon seey praapt aankadon kaa mulyankan kiya, jisamen twacha model aur eurticaria mein billastin kii prabhavkarita kaa vivaran diyaa gayaa haye taaki yeh aaklan kiya jaa sakey kii kyaa eurticaria mein updation key liye billastin kaa ishtatam profile haye. lekhakon ney nishkarsh nikala kii billastin kii prabhavkarita aur suraksha donon key liye ack utkrisht profile haye, halanki eurticaria key rogiyon mein vaastavik jeevan key adyatan adhyayan mein billastin kii prabhavkarita kii tulanaa karane key liye niyantrit naidaanik parikshanon kii aavashyakta haye, khujali niyantran parr vishesh dhyaan dete hue.
khuraak aur prashaasan.
billastin munh (poe) dwara lii gaee goli key roop mein aataa haye aur ise paani key saath poori tarah seey nigalana chaahiye. bhojan key 1 ghante pahale yaa 2 ghante baad key bheetar billastin naheen diyaa jaanaa chaahiye kyonki yeh isaki prabhavsheelta koo cumm curr sakata haye. alertin key liye australiyai khuraak dishanirdesh pratidin 20 milligram (ack goli) kii adhikatam khuraak dete hain. yakrit yaa gurde kii haani key liye khuraak parivartan kii aavashyakta naheen haye.
jabaki isake prabhaavon kii shuruat sutrikaran key beach bhinn hoti haye, billastin aam taur parr 30-60 minaton key bheetar prabhaav daaltaa haye. ise kewal 4 saal seey adhik umr key bachchon aur vayaskon, yaa 12 saal seey adhik umr key kissy bhee vyakti koo alertin key liye liya jaanaa chaahiye.
dushprabhaav.
maukhik aur antahshira prashaasan key baad choohon, choohon aur kutton mein preclinical vish vigyaan adhyayanon mein jaanch kii gaee billastin kii vishaaktata ney badey paimaane parr khuraak key maukhik prashaasan key baad koee mrityu darr naheen dekhi. antahshira prashaasan key baad, ell. dee. 50 (50 pratishat jaanvaron key liye ghaatak khuraak) moolya kramshah choohon aur choohon mein 33 aur 45-75 milligram/kigra they. 4 saptah key dauran maukhik roop seey (choohon, choohon aur kutton mein) yaa antahshira (choohon aur kutton mein) key roop mein badey paimaane parr billastin kii adhik matra key baad kissy bhee anga mein vishaaktata key koee sanket naheen dekhe gaye. prajanan kshamata parr koee prabhaav naheen padaa, koee terratogenic yaa utparivarti prabhaav naheen padaa, aur choohon, choohon aur khargoshon mein kiye gaye adhyayanon mein koee spasht carcinogenic kshamata naheen dekhi gaee.
naidaanik anusandhaan mein, billastin achchi tarah seey sahan kiya jaane vaalaa saabit huaa haye, swasth swayamsevakon mein placebo key samaan pratikool ghatnaaon key saath, ar aur puraane idiopathic eurticaria key rogiyon mein. halanki billastin aur levosaterizine yaa desloratadine kii sahishnuta profile bahut samaan thee, billastin koo saar mein naidaanik parakh mein saterizine kii tulanaa mein behtar sahan kiya gayaa thaa, jisamen billastin samooh mein cumm pratikool ghatanaaen theen. billastin key saath naidaanik parikshanon mein koee anticholinergic pratikool ghatanaaen naheen dekhi gaeen. shodh key dauran koee gambhir pratikool ghatanaaen naheen darj kii gaeen aur mahatvapurna sanketon, electrocardiography (ee. see. jee.) yaa prayogshala parikshanon mein koee naidaanik roop seey mahatvapurna parivartan naheen hue. pharmacokinetic/pharmacodynamic profile aur vishesh aabaadi mein adhyayan seey sanket milata haye kii bujurg rogiyon yaa purani yakrit bimari yaa purani gurde kii bimari mein billastin kii khuraak samaayojan aavashyak naheen haye.
hriday suraksha.
billastin kii naidaanik hriday suraksha kaa aaklan kaee naidaanik parikshanon mein kiya gayaa haye (3,500 seey adhik rogiyon kaa billastin key saath ilaaj kiya gayaa haye) aur ack charan I adhyayan (poori tarah seey qt/qtc adhyayan) mein ich e14 margadarshan aur khaadya aur dawa prashaasan (fda) seey sabse adhik maang aavashyaktaon key anusaar design kiya gayaa haye.jaba sabhi charan I adhyayanon seey electrocardiogram (ee. see. jee.) detta kaa vishleshan kiya jaataa haye, tou ekal khuraak (chikitsiya khuraak key 11 gunaa taka) parr billastin dene key baad kissy bhee mapdand mein koee mahatvapurna parivartan kii sarahana naheen kii jaati haye, naa hii kaee khuraakon (chikitsiya khuraak key 10 gunaa taka) parr. charan II aur III mein aeye. aar. aur articaria (12 maheenon key open-label extension charan sahit) parr kiye gaye adhyayanon seey ee. see. jee. mein parivartan naheen hotaa haye, naa hii billastin 20 milligram key prashaasan key baad kyu. tii. see. antaral key mahatvapurna vistaar kaa pataa chalata haye.
poori tarah seey qt/qtc adhyayan koo qt/qtc antaral parr prabhaav kaa aaklan karane key liye design kiya gayaa thaa, donon chikitsiya khuraak (20 milligram) aur 100 milligram billastin, lekin catoconazole (400 milligram/dinn) kii samanya khuraak key saath chikitsiya khuraak kaa saha-prashaasan, ack chayapachaya avarodhak aur ack pee-gp nirbhar parivahan pranali. yeh satyaapit kiya gayaa thaa kii 4 dinon key dauran prashaasit billastin 20 aur 100 milligram, kissy bhee vyakti mein cuty/qtc antaral avadhi mein mahatvapurna parivartan naheen laataa haye. isi tarah, billastin 20 milligram aur catoconazole 400 milligram kaa saha-prashaasan billastin key kaaran honey vaale qt/qtc antaral kaa koee mahatvapurna vistaar naheen kartaa haye.
antahkriyaaen.
preclinical detta seey pataa chalata haye kii billastin aur davaaon yaa pee-glycoprotein key avarodhak yaa prerak khaadya padarthon key beach baatchit kii sambhavana haye. billastin aur grapefruit key russ (ack gyaat pee-glycoprotein-madhyasth dawa parivahan sakriyak) key saha-prashaasan ney billastin pranaaleegat sampark koo kaafee cumm curr diyaa. yeh antahkriya aanton key parivahan pranali jaise pee-glycoprotein aur peptide (otpi) parivahan karane vaale carbonic aayan parr grapefruit flavonoids key gyaat prabhaav key kaaran hoti haye.
pharmacology.
pharmacodynamics.
billastin ginny-pig cerebeller histamine histamine (kii = 44 nm) aur maanav punarsanyojit histamine histamine (kii = 64 nm) seey ack sambandh key saath systemizole aur diphenhydramine key saath tulaniya haye, aur saterigin kii tulanaa mein teen gunaa aur phexophenadine kii tulanaa mein paanch gunaa (corkestagui) behtar haye. vibhinn murine model mein, maukhik maarg seey billastin, histamine key prabhaavon koo khuraak-nirbhar tareeke seey virodh kartaa haye, jisamen saterigin key samaan shakti hoti haye aur phexophenadine kii tulanaa mein 5.5 aur 10 gunaa adhik hoti haye.
poorv naidaanik jaanch anya histamine receptors upprakaron aur vibhinn amine seey anya 30 receptors kii tulanaa mein histamine histamine key liye billastin kii aatmiyata aur vishishtata koo pradarshit karati haye. inn vivo prayog ney antihistaminic aur antiallurgic gatividhi kii pushti kii, joe cumm seey cumm doosari peedhi key key jaise saterizine key saath tulaniya thee.
pharmacokinetics.
avashoshan.
bhojan kii anupasthiti mein billastin sabse jaldi avashoshit hoe jaataa haye, aur ekal aur ekaadhik khuraak donon key baad lagbhag 1 ghante key 220 ng/ml kii ausat charam plasma sandrata taka pahunch jaataa haye. uchch vasaa vaale nashte yaa falon key russ seey avashoshan cumm hoe jaataa haye, aur anumaanit vaishvik maukhik jaiv upalabdhata lagbhag 60 pratishat haye. billastin mein upchaar key 14 dinon key baad sanchay key pramaan key binaa swasth vayask vishayon mein 2.5-220 mg khuraak seema mein raikhik pharmacokinetics haye.
vitaran.
billastin vitaran mein vitaran kii ack spasht matra 1.29 ell/kigra haye, aur iska unmoolan aadhaa jeevan 14.5 aich aur 84-90% kaa plasma protein bandhan haye.
billastin ack paridhiya roop seey chayanaatmak dawa haye, aur yeh pee-glycoprotein key bandhan key kaaran mastishk mein seemit grahan key kaaran maanaa jaataa haye.
chayapachaya.
radiolabeld billastin key saath ack charan I dravyamaan-santulan adhyayan key anusaar, billastin manushyon mein mahatvapurna roop seey chayapachaya naheen hotaa haye aur mootra aur mull donon mein kaafee hudd taka aparivartit rahata haye-prashaasit khuraak kaa ack tihai aur dou tihai, kramshah. billastin aasaani seey rakt mastishk baadha koo paar naheen kartaa haye aur yakrit dwara chayapachaya naheen kiya jaataa haye. prashaasit khuraak kaa 96 pratishat 24 ghanton key bheetar samaapt hoe jaataa haye.
apane antihistamine prabhaav key sambandh mein, 24 ghante key liye twacha key pahiye aur bhadakane vaali satah key roop mein maapa jaane vaalaa billastin kii dainik 20 milligram kii maukhik khuraak, billastin poore prashaasan antaral key dauran satah key 50 pratishat kshetron koo rokane mein saksham haye.
rasayan vigyaan.
billastin, yaa 2-[4-[4-[1-[2-ethoxyethyl) benzemidazole-2-yl] piperidine-1-yl] ethyl] phenyl]-2-methylpropionic acid, 463.6 dalton key aanvik vajan aur piperidinil-benzeemidaazol key samaan ack rasayanik sanrachana vaalaa ack nayaa anu haye. isaliye billastin koo bajar mein kaee nae antihistamine key samaan rasayanik samooh mein vargeekrit kiya jaa sakata haye, halanki yeh sanrachanaatmak roop seey vyutpann naheen haye, naa hii yeh unamen seey kissy kaa chayapachaya yaa anantiomer haye, lekin ack mool anu haye jise doosari peedhi key antihistamine kii sabhi aavashyaktaon koo puuraa karane key iraade seey design kiya gayaa haye.
shodh.
vibhinn khuraakon kaa upayog karate hue naidaanik adhyayan histamine-prerit wheel aur flair pratikriya parr 24 ghante kii avadhi mein kiye gaye they, jabaki saterigin kii ack 10-milligram maukhik khuraak kii tulanaa mein. iss shodh key parinamon ney sanket diyaa kii swasth swayamsevakon mein histamine-madhyasth prabhaavon koo cumm karane mein billastin cumm seey cumm saterigin jitna hii kushal thaa. vishesh roop seey, 20 aur 50 milligram billastin ney citerizine kii tulanaa mein teji seey wheel aur flair pratikriya koo cumm curr diyaa.

