carnitine palmitoyaltransphress aaee

carnitine palmitoyaltranspherase aaee (see. pee. tii. 1) jise carnitine assiletransferase aaee, see. pee. tii. aaee, aaee, see. oh. aeye. key roop mein bhee jaanaa jaataa haih carnitine asyl transfer (see. see. tii.), yaa palmitoyalkoa transfer aaee, ack mitochondrial enzyme haye joe coenzyme aeye seey ell-carnitine mein lambi shrinkhala vaale fatty asyl-coa key asyl samooh key hastaantaran koo utprerit karke asil carnetines key gathan key liye jimmedaar haye. utpaad aksar palmitoyalkarnitine (iss prakaar naam) hotaa haye, lekin anya vasaayukt aml bhee substrate hoe sakate hain. yeh carnetin assiletransferess naamak enzymon key parivaar kaa hissa haye. yeh "taiyari" cytosol seey mitochondria key antar-jhilli sthaan mein asil carnitine key baad key andolan kii anumati detee haye.
vartamaan mein see. pee. tii. 1 key teen samroop gyaat hainh see. pee. tii. 1 aeye., see. pee. tii. 1 bee. aur see. pee. tii. 1 see.. see. pee. tii. 1 baahari mitochondrial jhilli seey judaa huaa haye. iss enzyme koo malonil koye dwara rokaa jaa sakata haye, joe fatty acid sanshleshan key dauran utpaadit pahala pratibaddh madhyavarti haye. fatty acid chayapachaya mein isaki bhoomika see. pee. tii. 1 koo madhumeh jaise kaee chayapachaya vikaaron mein mahatvapurna banaati haye. choonki isaki chrystal sanrachana gyaat naheen haye, isaliye isaki kaarravaai kaa sateek tantra nirdhaarit kiya jaanaa baaki haye.
sanrachana.
see. pee. tii. 1 ack abhinn jhilli protein haye joe standhari ootakon mein teen isophorm mein maujood haih see. pee. tii. 1aeye, see. pee. tii. 1bee aur see. pee. tii. 1see. pahale dou adhikansh ootakon kii baahari mitochondrial jhilli parr vyakt kiye jaate hain, lekin unake saapeksh anupaat ootakon key beach bhinn hotey hain. see. pee. tii. 1aeye. yakrit jaise lipogenic ootakon mein pramukhta seey paaya jaataa haye, jabaki see. pee. tii. 1bee. hriday aur kankal kii maanspeshiyon jaise ootakon mein pramukhta seey paaya jaataa haye, jinamen uchch vasaa aml oxidative kshamata hoti haye.braun edipose koshikaaen. donon samroop peptide shrinkhala mein dou transmembrane kshetron key madhyam seey mitochondrial baahari jhilli key abhinn protein hain. see. pee. tii. 1aeye. kii jhilli topology kaa varnan isake dwara kiya gayaa thaa, jisamen aine-aur see-terminal donon ome key cytosolic pahalu parr ujagar hotey hain, jisamen ack chhota loop dou transmembrane domen koo mitochondrial inter-membrane space mein jodata haye.
teesara isophorm (see. pee. tii. 1. see.), 2002 mein pahachaana gayaa thaa aur mitochondria aur endoplasmic reticulum donon mein vyakt kiya gayaa haye. yeh aam taur parr kewal tantrika koshikaon (mastishk) mein vyakt kiya jaataa haye, halanki isaki abhivyakti kuchh cancer koshika prakaron mein badal jaati haye. 
see. pee. tii. 1 isophorm mein seey kissy kii bhee sateek sanrachana abhee taka nirdhaarit naheen kii gaee haye, halanki see. pee. tii. 1 key liye vibhinn prakaar key "inn silico" model nikatata seey sambandhit carnitine assiletransferess jaise carnitine acetyltransferase (crate) key aadhar parr banaae gaye hain.
see. pee. tii. 1 aur see. pee. tii. 2, crate aur carnitine octanoiltransferase (see. tii.) key beach ack mahatvapurna sanrachanaatmak antar yeh haye kii see. pee. tii. 1 mein isake aine-terminal parr ack atirikt domen hotaa haye jisamen lagbhag 160 emino acid hotey hain. yeh nirdhaarit kiya gayaa haye kii yeh atirikt aine-terminal domen see. pee. tii. 1, malonil-coa key pramukh avarodhak anu key liye mahatvapurna haye, aur ack switch kii tarah kaary kartaa haye joe see. pee. tii. 1aeye koo malonil-coa avrodh key liye cumm yaa jyada samvedansheel banaata haye. 
see. pee. tii. 1aeye. aur see. pee. tii. 1bee. mein dou alag-alag bandhan sthal prastaavit kiye gaye hain. ack site" yaa "koo site" melonil-coa aur palmitoyal-coa donon key saath-saath coenzyme aeye vaale anya anuon koo baandhata huaa dikhaai detaa haye, yeh sujhaav dete hue kii enzyme inn anuon koo coenzyme key saath baatchit key madhyam seey baandhata haye. yeh sujhaav diyaa gayaa haye kii melonil-coa iss site parr see. pee. tii. 1aeye. key pratispardhi avarodhak key roop mein vyavhaar curr sakata haye. ack site kii tulanaa mein malonil-coa koo adhik kaskar baandhane key liye ack doosara "oh site" prastaavit kiya gayaa haye. ack site key vipareet, oh site malonil-coa key malonal-coa key malonal samooh key madhyam seey malonil-coa seey judati haye. aeye aur oh saiton key liye malonil-coa kaa bandhan see. pee. tii. 1aeye. key liye carnitine key bandhan koo chhodkar see. pee. tii. 1aeye. kii kaarravaai koo rokta haye. choonki see. pee. tii. 1aeye. kii ack chrystal sanrachana koo abhee taka alag aur chitrit naheen kiya gayaa haye, isaliye isaki sateek sanrachana koo spasht kiya jaanaa baaki haye.
kaary.
enzyme tantra.
kyonki chrystal sanrachana detta vartamaan mein upalabdh naheen haye, cpt1 kaa sateek tantra vartamaan mein gyaat naheen haye. see. pee. tii. 1 key liye kuchh alag sambhaavit tantron koo abhinirdhaarit kiya gayaa haye, jinamen seey donon mein hystidine avashesh 473 pramukh utprerak avashesh key roop mein shamil haye. ack carnitine acetyltransferase model parr adharit aisaa ack tantra neeche dikhaaya gayaa haye jisamen uska 473 deprotonate carnitine hotaa haye jabaki paas kaa ack serin avashesh tetrahedral auxianian madhyavarti koo sthir kartaa haye.
ack alag tantra prastaavit kiya gayaa haye joe bataata haye kii avasheshon seey banaa ack utprerak trikoniya see. aaee. aiss-305, usake-473, aur aeye. aiss. pee.-454 utpreran key asyl-sthanantaran charan koo puuraa kartaa haye. iss utprerak tantra mein see. aaee. aiss-305 key saath ack theoacyl-enzyme sahsanyojak madhyavarti kaa gathan shamil haye.
javic kaary.
carnitine palmitoyaltranspherase pranali lambi shrinkhala vaale fatty acid key beeta-okseekaran mein ack aavashyak kadam haye. yeh sthanantaran pranali aavashyak haye kyonki, jabaki fatty acid baahari mitochondrial jhilli parr sakriya hotey hain (coenzyme aeye key liye ack theoester linkage key roop mein), sakriya fatty acid koo mitochondrial matricks key bheetar aukseekrit kiya jaanaa chaahiye. laghu aur madhyam-shrinkhala vaale fatty acid key vipareet, palmitoyal-coa jaise lambi shrinkhala vaale fatty acid, mitochondrial aantarik jhilli key madhyam seey swatantra roop seey fail naheen sakate hain, aur mitochondrial matricks mein leey jaane key liye ack shuttle pranali kii aavashyakta hoti haye.
carnitine palmitoyaltranspherase aaee carnitine palmitoyaltranspherase pranali kaa pahala ghatak aur darr-seemit karane vaalaa kadam haye, joe coenzyme aeye seey carnitine mein asil samooh key sthanantaran koo utprerit kartaa haye taaki palmitoilcarnitine bunn sakey. ack translocase taba aantarik mitochondrial jhilli mein asyl carnitine koo shuttle kartaa haye jahan ise vaapas palmitoyal-coa mein parivartit kiya jaataa haye.
ack asyl samooh sweekaarak key roop mein kaary karke, carnitine antahkoshikiya koeh asyl-koye anupaat koo viniyamit karane kii bhoomika bhee nibha sakata haye.
viniyaman.
see. pee. tii. 1 koo melonil-coa dwara baadhit kiya jaataa haye, halanki avrodh kaa sateek tantra agyaat haye. see. pee. tii. 1 kankal manspeshi aur hriday isophorm, see. pee. tii. 1bee, koo see. pee. tii. 1aeye. kii tulanaa mein melonil-coa avrodh key prati 30-100-gunaa adhik samvedansheel dikhaaya gayaa haye. yeh avrodh chayapachaya vikaaron key upchaar key liye see. pee. tii. 1 koo viniyamit karane key bhavishya key prayason key liye ack achchha lakshya haye.
acetyl-coa carboxylase (aeye. see.), vaha enzyme joe acetyl-coa seey malonil-coa key gathan koo utprerit kartaa haye, fatty acid chayapachaya key viniyaman mein mahatvapurna haye. vaigyaanikon ney pradarshit kiya haye kii jangli prakaar key choohon kii tulanaa mein aeye. see. 2 nockout choohon ney shareer kii charbi aur vajan cumm curr diyaa haye. yeh aikee kii gatividhi mein kamee kaa parinam haye joe baad mein malonil-coa sandrata mein kamee kaa kaaran banata haye. yeye malonil-coa key star koo cumm karate hain aur see. pee. tii. 1 key avrodh koo rokte hain, jisase fatty acid okseekaran mein antim vriddhi hoti haye. choonki hriday aur kankal kii maanspeshiyon kii koshikaon mein vasaa aml sanshleshan kii kshamata cumm hoti haye, isaliye assie inn koshikaon mein vishuddh roop seey ack niyaamak enzyme key roop mein kaary curr sakata haye.
naidaanik mahatva.
cpt1a" roop carnitine palmitoyaltranspherase i kii kamee seey judaa huaa haye. yeh durlabh vikaar yakrit mastishk vikriti, hypocatotic hypoglycemia, daure aur bachpan mein achaanak apratyaashit mrityu key liye jokhim pradaan kartaa haye.
see. pee. tii. 1 type 2 madhumeh aur insulin pratirodh seey judaa huaa haye. iss tarah kii beemaariyaan, kaee anya swaasthya samasyaon key saath, manushyon mein mukt vasaa aml (aff. aff. aeye.) kaa star badh jaataa haye, kankal kii maanspeshiyon mein vasaa jamaa hoe jaati haye, aur maanspeshiyon kii vasaa aml koo aukseekrit karane kii kshamata koo cumm curr detee haye. see. pee. tii. 1 koo inn lakshnon mein yogdan karane mein shamil kiya gayaa haye. hyperglycemia aur hyperinsulinaemia key kaaran honey vaale malonil-coa key badhe hue star see. pee. tii. 1 koo rokte hain, joe baad mein maanspeshiyon aur hriday mitochondria mein lambi shrinkhala vaale fatty acid key parivahan mein kamee kaa kaaran banata haye, jisase aisee koshikaon mein fatty acid okseekaran cumm hoe jaataa haye. mitochondria seey door ell. see. aff. aeye. key shunt seey aff. aff. aeye. key star mein vriddhi hoti haye aur kankal kii maanspeshiyon mein vasaa jamaa hoti haye.
fatty acid chayapachaya mein iska mahatva see. pee. tii. 1 koo kaee anya chayapachaya vikaaron key upchaar key vikas mein dhyaan kendrit karane key liye ack sambhaavit upayogi enzyme banaata haye.
antahkriyaaen.
see. pee. tii. 1 koo kaee proteins key saath antahkriya karane key liye jaanaa jaataa haye, jisamen aine. dee. yuu. aff. parivaar, pee. key. see. 1 aur aine. oh. 1 shamil hain.
aich. aaee. vee. mein, vee. pee. aar. koshikaon mein piparbeta/delta-prerit pee. dee. key. 4, carnitine palmitoyaltransphress aaee (see. pee. tii. 1) aim. aar. aine. aeye. abhivyakti koo badhaata haye. shrana library screening dwara see. pee. tii. 1aeye. kii nokdown samvardhit jurkat tii-koshikaon mein aich. aaee. vee.-1 pratikriti koo rokti haye.

