endexanate alfa

aur anya key beach vyaapaar naam aur xxa key tahat becha jaane vaalaa endexnet alfa, davaaon rivaroxaban aur epixaban key liye ack antidote haye, jaba aniyantrit raktasraav key kaaran anticoagulation key ulatane kii aavashyakta hoti haye. yeh anya kaarak xa avrodhakon key liye upayogi naheen paaya gayaa haye. yeh ack nus mein injection dwara diyaa jaataa haye.
samanya dushprabhavon mein pneumonia aur mootra path key sankraman shamil hain. gambhir dushprabhavon mein rakt key thakke, dill kaa daura, stroke yaa cardiac arrest shamil hoe sakate hain. yeh rivaroxaban aur epixaban koo bandhkar kaam kartaa haye.
ise maee 2018 mein sanyukt raajya america mein chikitsa upayog key liye anumodit kiya gayaa thaa. ise portola pharmaceuticals dwara vikasit kiya gayaa thaa.
chikitsa upayog.
endexanate alfa kaa upayog una logon mein jeevan key liye khatarnak yaa aniyantrit raktasraav koo rokane key liye kiya jaataa haye joe rivaroxaban yaa epixaban leey rahey hain.
2019 taka koee yaadrichhik naidaanik pareekshan naheen hain. swasth swayamsevakon mein adhyayanon seey pataa chalata haye kii anu kaarak xa avrodhakon koo baandhata haye aur unaki anty-xa-gatividhi kaa mukabala kartaa haye. ekmatra prakaashit naidaanik pareekshan ack sambhaavit, khula label, ekal samooh adhyayan haye. yeh adhyayan 352 logon parr parinam bataata haye aur anty-xa-activity mein kamee darshaata haye jabaki 82 pratishat mein ack utkrisht yaa achchi haemostatic prabhavkarita bhee dikhaata haye. jinn logon key 30 dinon mein marane kii ummeed thee, unhein adhyayan seey baahar rakhaa gayaa thaa, 14 pratishat pratibhagiyon kii mrityu hoe gaee. haemostatic prabhavkarita aur cumm anty-xa-activity key beach koee sambandh naheen thaa. fda ney ack yaadrichhik naidaanik pareekshan kii maang kii haih pahale parinamon kii 2023 seey pahale ummeed naheen haye.
pratikool prabhaav.
samanya dushprabhavon mein pneumonia aur mootra path key sankraman shamil hain. gambhir dushprabhavon mein rakt key thakke yaa hriday gati rukna shamil hoe sakata haye.
endexanate alfa mein ack chaukadidar chetavani haye kii yeh dhamani aur shiraparak rakt key thakkon, ischemic ghatnaaon, hriday gati rukane aur achaanak mauton seey judaa huaa haye.
pharmacology.
kaarravaai kaa tantra.
endexanate alfa ack javic agent haye, joe maanav sakriya kaarak x (fxa) kaa ack punarsanyojit sanshodhit sanskaran haye. aurexanate alfa deshi fxa seey alag haye kyonki 34 avashesh tukade koo hataa diyaa jaataa haye jisamen gla domen hotaa haye. yeh sanshodhan endexanate alfa kii anticoagulant kshamata koo cumm kartaa haye. isake alawa, sakriya sthal mein ack serin seey elenin elenin utparivartan thrombin utprerak key liye ack prothrombin key roop mein isaki gatividhi koo samaapt kartaa haye, lekin phir bhee anu koo fxa avrodhakon seey baandhane kii anumati detaa haye. fxa avarodhak praakritik fxa key samaan lagaav key saath endexanate alfa seey judate hain. parinamswarup endexanate alfa praakritik fxa kii upasthiti mein aanshik roop seey mukt hoe jaataa haye, jisase prabhaavi haemostasis hoe sakata haye. dusare shabdon mein, yeh ack dcoy receptor key roop mein kaary kartaa haye. endexanate alfa una sabhi anticoagulants key prabhaav koo ulat detaa haye joe seedhe fxa key madhyam seey yaa antithrombin III koo bandhkar kaary karate hain. dawa kaarak aaee. aaee. aeye. avarodhak dabigatron key khilaf prabhaavi naheen haye. isaki gatividhi koo anty-xa pareekshan kaa upayog karke maapa jaataa haye, jiska upayog jamaavat key liye upalabdh kaarak xa kii matra nirdhaarit karane key liye kiya jaataa haye.
itihas.
ise 2018 mein sanyukt raajya america mein dou charan III adhyayanon key detta key aadhar parr swasth swayamsevakon mein fxa avarodhak rivaroxaban aur epixaban kii anticoagulant gatividhi koo ulatane parr anumodit kiya gayaa thaa. isaki twarit manjuri kii shart key roop mein, vartamaan mein upayog kiye jaane vaale anya riversal agents ("samanya dekhbhal") seey isaki tulanaa karane key liye ack adhyayan kiya jaa rhaa haye.
samaaj aur sanskriti.
arthshastra.
praarambhik moolya nirdhaaran (aeye. doubleu. pee.) prati prativarti 58,000 dollar (800 milligram bolus + 960 milligram infusion, 3,300 dollar prati 100 milligram sheeshi) haye joe anya doek agents key liye prativarti agents kii tulanaa mein adhik haye (dabigtron prativarti mein upayog key liye idarusizumab 4,200 dollar prati prativarti haye).

