
pree-metastatic aalaa

ack poorv-metastatic aalaa ack maadhyamik anga mein ack vatavaran haye joe ack praathamik tumour key metastasis key liye anukool hoe sakata haye. iss tarah kaa ack sthaan praathamik tumour koshikaon key liye ack anyatha videshi aur pratikool vatavaran mein vikas key liye anukool paristhitiyaan pradaan kartaa haye, aur antatah metastasis. iss avadharana ney tumour key vikas aur metastasis koo niyantrit karane mein sookshm paryaavaran kii maulik bhoomika kaa pradarshan kiya. pree-metastatic aalaa kii khoj ney metastes key sambhaavit upchaar key sambandh mein nae shodh koo badhaava diyaa haye, jisamen myeloid vyutpann daman koshikaon koo lakshit karna, aur fibroblast aur pericites aur perivascular chikani maanspeshiyon sahit stromal cell plasticity aur (praathamik tumour seey praathamik angon mein pree-metastatic aalaa aur sookshm paryaavaran lakshit upchaaron key vibhinn sanyojanon mein putikaon key pravaah koo rokane kaa prayaas.
poorv-metastatic aalaa gathan.
chikitsakiya roop seey praasangik metastasis key gathan seey pahale inn vishesh sthalon parr rakt-sanchari asthi majja koshikaon key pravaas key kaaran tumour metastasize hoe jaate hain joe wegf1 (samvahani endothelial vikas kaarak receptor 1) aur stromal koshikaon koo vyakt karate hain. yeye koshikaaen baahya koshikiya matricks mein parivartan key saath poorv-metastatic sthaan banaati hain joe tumour koshikaon key prasaar kaa samarthan karati hain aur inn koshikaon koo ikattha karane aur anga koo adhik aasaani seey upaniveshit karane kii anumati detee hain. poorv-metastatic aalaa gathan kaee alag-alag shaaririk prakriyaon seey prabhaavit hotaa haye, jisamen pratiraksha pranali kaa daman aur cytokins aur anya vikas karakon kii upasthiti mein vriddhi shamil haye. aur baahya koshikiya matricks nikshepan aur punarnirmaan 
praathamik tumour mein hypoxia aur praathamik tumour seey maadhyamik anga mein exosome kii gati atirikt ghatanaaen hain joe poorv-metastatic sthaan key gathan key liye aanshik roop seey jimmedaar hain.
metastasis mein bhoomika.
metastasize karane key liye, tumour koshikaon koo ack aise anga mein pahunchana chaahiye joe unake vikas key liye anukool vatavaran key saath hoe, jaise kii ack poorv-metastatic aalaa. iss vatavaran kaa nirmaan praathamik tumour key karakon dwara kiya jaataa haye joe praathamik tumour seey koshikaon koo adhik aasaani seey maadhyamik anga koo upaniveshit karane kii anumati dene key liye maadhyamik anga kii sanrachana koo badal dete hain. tumour koshikaaen aise kaarak chhodati hain joe huddy kii koshikaon koo phir seey avashoshit karate hain aur isaliye metastasis kii darr koo badhaate hain. huddy metastatic prakriya key liye anukool haye kyonki isaki sanrachana kaee vibhinn prakaar kii koshikaon kii haye aur isaki kankal sanrachanaon koo vikasit karane kii kshamata haye. poorv-metastatic aalaa gathan kii prakriya key binaa, metastes honey kii sambhavana cumm hoti haye. aksar metastasis key binaa angon mein tumour koshika jamaa paae jaate hain, joe darshaata haye kii metastasis hamesha una ootakon mein naheen failate hain joe way parisancharan pranali koo chhodane key baad pravesh karate hain.
pratiraksha pranali kii bhoomika.
sakriya pratiraksha daman key kaaran badey hisse mein poorv-metastatic aalaa kaa gathan sambhav haye. praathamik tumour myeloid vyutpann daman koshikaon kii bharti karate hain, joe myeloid koshikaaen hain joe pratijan prastuti aur tii koshikaon kii madhyasthata vaali cytotoxicity koo roque sakati hain, taaki tumour koshikaon koo pratiraksha pranali dwara pataa lagaane seey bachane kii anumati dee jaa sakey kyonki way metastasize karate hain, aur iss prakaar metastasis koo phalane-phoolane kii anumati detaa haye. jaise hii praathamik tumour raktapravaah mein tumour koshikaon koo chhodate hain, tumour dwara bharti kii gaee myeloid koshikaaen cancer koshikaon koo anukuli pratiraksha pranali dwara pataa lagaane seey bachaa sakati hain, joe anyatha metastasis koo roque sakati hain. myeloid progenitor koshikaaen, joe apane koshika vikas mein vibhinn vibhinn charanon mein bharti kii jaati hain, maanaa jaataa haye kii way poorv-metastatic aalaa kaa gathan karati hain, kyonki way tumour koshikaon koo maanak pratiraksha pratikriya seey bachaa sakati hain kyonki cancer koshikaaen poorv-metastatic aalaa koo upaniveshit karane kaa prayaas karati hain. naa kewal badhati metastasis koo pratiraksha pranali key hamalon seey bachaane mein, balki atirikt prasaar koo saksham karane mein bhee unaki mahatvapurna bhoomika koo dekhate hue, myeloid koshikaaen poorv-metastatic aalaa key vikas mein ack pramukh kaarak hain, aur iss prakaar antatah metastes koo badhaava dene mein.
sanket anuon kaa ack varg, kemokin, poorv-metastatic sthaan aur metastes key nirmaan mein bhee mahatvapurna bhoomika nibhaate hain. praathamik tumour, pratiraksha pranali dwara pataa lagaane seey bachane key prayaas mein, asthi majja seey praapt myeloid koshikaon kii maadhyamik angon mein bharti badhaane key liye chemokins kaa upayog kartaa haye. isake alawa, praathamik tumour seey cancer koshikaon kaa upayog maadhyamik anga mein poorv-metastatic aalaa key bhavishya key sthal mein soojan koo prerit karane key liye kiya jaa sakata haye, joe ack sankraman dwara banaai gaee pratiraksha pratikriya key samaan haye.
iss prakaar, pratiraksha koshikaon kii badee upasthiti poorv-metastatic aalaa koo pratiraksha pranali dwara hamalon koo rokane kii anumati detee haye aur isaliye tumour koo binaa kissy avrodh key metastasize karane kii anumati detee haye. pratiraksha daman, hypoxia aur acm key saath sanyukt, anya prakriyaon key beach, ack praathamik tumour koo metastasize karane kii anumati dene key liye aavashyak kadam hain, kyonki way pratiraksha pranali kii vishisht pratikriya seey nasht hue binaa tumour koshikaon koo videshi aur pratikool vatavaran mein badhane kii anumati dete hain. vishesh roop seey, aavashyak amino acid samaapt hoe jaate hain aur lymphocyte andolan cumm hoe jaataa haye jabaki niyaamak tii koshikaaen, joe pratiraksha pranali koo dabaati hain, aur oxidative tanaav badh jaataa haye.
poorv-metastatic aalaa kii khoj.
metastasis koo aam taur parr kuchh saral charanon mein sanghanit kiya gayaa haye, arthaat kii tumour koshikaaen praathamik tumour koo chhod detee hain aur poorv-metastatic anga key videshi vatavaran parr aakraman karane key prayaas mein parisancharan pranali key madhyam seey maadhyamik angon kii yatra karati hain. choonki tumour kaa vikas aksar ack nae aur apekshaakrit pratikool vatavaran mein mushkil hotaa haye, isaliye uchch mrityu darr key bavjood metastasis koo kaee logon dwara ack aksham prakriya maanaa gayaa thaa. halanki stephen pegget kii pahale seey sthaapit 'beej aur mitty' parikalpana praathamik tumour koshikaon key poorv-metastatic sthaan parr sthanantarit honey key nae vichaar key saath sambandhit haye, kaee shodhkartaon kaa dhyaan praathamik tumour seey sthanantarit hoe rhaa haye, ack tumour kii upasthiti mein metastasis kii anumaanit anivaaryata koo dekhate hue, maadhyamik angon mein jahaan metastes hotey hain. metastasis key liye praathamik angon mein exosome kii bhoomika haal hii mein shodhkartaon key beach baatchit kaa ack mahatvapurna vishay bunn gaee haye, kyonki badey hisse mein metastasis key binaa angon mein tumour koshikaon key jamaa honey kii khoj hui haye. poorv-metastatic aalaa kii avadharana kii khoj david lyden kii prayogshala mein dow. aiss. dwara kii gaee thee. david lyden aur stergios zacharaulis, aur poorv-metastatic aalaa koo pahale dow. aiss. dwara varnit aur visheshta dee gaee thee. rosendra kaplan, rebekka reeba, stergios zacharaulis aur anya.2005 mein.
cancer key upchaar key liye prabhaav.
pree-metastatic aalaa kii avadharana kii maanyata shodhkartaon koo cancer key ilaaj key liye kaee naee sambhaavanaon parr vichaar karane kii anumati detee haye. aisee hii ack sambhavana haye koshikaon mein wagfr1 kii abhivyakti koo seemit karane kaa prayaas karane vaale tarikon kaa upayog karna, jisase poorv-metastatic aalaa key nirmaan mein deree karke yaa poori tarah seey unmoolan karke metastasis kaa mukabala kiya jaa sakey. praathamik tumour mein hypoxia koo lakshit karna aur pratiraksha pranali kaa daman bhee pree-metastatic sthaan key nirmaan koo roque sakata haye. praathamik tumour key kaarak joe tumour koshikaon dwara isake upanivesheekaran koo suvidhajanak banaane key liye maadhyamik anga koo sanrachanaatmak roop seey badal dete hain, way bhee metastasis koo rokane key prayaas mein sambhaavit roop seey lakshit kiye jaa sakate hain.
vibhinn sookshm vatavaran mein ugaai jaane vaali tumour koshikaaen vibhinn prakaar key protein detee hain, joe darshaati hain kii alag-alag sthaanon mein tumour key liye vibhinn prakaar key oncological upchaar kii aavashyakta hoti haye. metastasis key baad key charanon koo lakshit karna aasaan haye kyonki cancer aksar taba taka naheen paaya jaataa haye jaba taka kii metastasis key shuruati charan poore naheen hoe jaate hain. iss prakaar, praathamik upchaaron aur davaaon kaa ack sanyojan joe metastasis kaa mukabala karate hain, kaa upayog tumour koshikaon dwara ack maadhyamik anga key upanivesheekaran koo rokane key liye kiya jaa sakata haye, kyonki yeh tumour seey bahane vaali koshikaon aur poorv-metastatic aalaa key gathan donon koo roque dega. vaikalpik roop seey, tumour koshikaon koo poorv-metastatic sthaan parr jaane seey rokane key liye davaaon kaa upayog karna metastes koo rokane kaa ack prabhaavi tarika hoe sakata haye.