
anty-maig paridhiya neuropathy

anty-maig paridhiya tantrika vikriti ack vishisht prakaar kii paridhiya tantrika vikriti haye jisamen vyakti kii apani pratiraksha pranali una koshikaon parr hamla karati haye joe ack swasth tantrika tantra koo banaae rakhane mein vishisht hain. jaise-jaise yeye koshikaaen antibody dwara nasht hoe jaati hain, aspas key kshetra mein tantrika koshikaaen kaary karna shuru curr detee hain aur samvedi aur motor donon kaary mein kaee samasyaaen paida karati hain. vishesh roop seey, myelin seey judey glycoprotein (maig) key khilaf antibody shwan koshikaon koo nuksan pahunchaate hain. jabaki paridhiya tantrika vikriti seey peedit logon mein seey kewal 10 pratishat mein vikaar hotaa haye, peedit logon mein maanspeshiyon kii kamjori, samvedi samasyaaen aur anya motor kii kamee jaise lakshan hotey hain joe aamtaur parr haathon key compcompy yaa chalane mein pareshani key roop mein shuru hotey hain. haalaanki, aise kaee upchaar hain joe saral abhyason seey laker lakshit dawa upchaar taka hain joe iss prakaar kii paridhiya tantrika chikitsa vaale logon mein kaary mein sudhaar karane key liye dikhaae gaye hain.
prishthabhoomi.
shwan koshikaon dwara myelination.
mylin neuron koshikaon kaa ack mahatvapurna hissa haye aur neuron kii kriya kshamata koo teji seey aur adhik lagaatar yatra karane kii anumati dene vaalaa insulation pradaan kartaa haye. insulation pradaan karane key liye, nikatata seey virodhi jhilli kii kaee paraton koo akshatantu key chaaron or lapeta jaataa haye. ack vidyut avaahak key roop mein kaary karke, akshatantu kii chaalan kshamata mein kaafee teji aatee haye jisase kuchh mamalon mein lagbhag pandrah gunaa teji seey, bahut tej darr seey yatra karane kii anumati milati haye. yeh kshamata tantrika tantra koo sandeshon koo teji seey aur adhik sateek roop seey bhejane kii anumati detee haye. samanya roop seey myelinated koshikaon parr mylin aavaran kaa vyavadhaan kriya kshamata key risaav kii anumati detaa haye jaise kii ack doshpurna taar ack paripath mein bijli key risaav kii anumati dega. yeh una nason key saath bheje jaa rahey sandeshon koo dheema curr detaa haye aur samanya kaary koo baadhit kartaa haye.
shwan koshikaaen paridhiya tantrika tantra mein koshikaaen hain joe neurons parr mylin sheeth banaati hain aur banaae rakhti hain. yeye paridhiya tantrika tantra kii glial koshikaaen hain aur akshtantuon key aspas sthit hain joe way seva karate hain. inn koshikaon koo nuksan key parinamswarup mylin aavaran kaa apakshay hotaa haye aur anivarya roop seey tantrika tantra key liye sanchaar mein samasyaaen paida hoti hain.
myelin-sambaddh glycoprotein.
myelin-sambaddh glycoprotein (maig) ack glycoprotein haye joe shwan koshikaon key liye vishisht haye, joe paridhiya tantrika tantra mein tantrika koshikaon key liye myelin banaata haye. choohe key maig jeane kii cloning key madhyam seey shodh seey pataa chalaa haye kii yeh ack prakaar kaa aaee transmembrane protein haye jiska arth haye kii isamen koshika jhilli key ander aur koshika jhilli key baahar donon kshetra hotey hain. iss glycoprotein kii abhivyakti myelin banaane vaali koshikaon key liye bahut vishisht haye aur kendriya tantrika tantra mein akshtantuon key praarambhik vikas mein kaary karane key liye myelination prakriya mein bahut jaldi shuru hoti haye. yeh abhivyakti paripakva jaanvaron mein bhee apekshaakrit adhik bunny hui haye, haalaanki, yeh sujhaav detaa haye kii yeh naa kewal gathan balki rakharkhaav seey bhee judaa huaa haye.
nockout choohon key madhyam seey shodh, yaa maig jeane koo hataae gaye choohon seey pataa chalaa haye kii yeh glycoprotein myelin key gathan mein bahut adhik kaary kartaa haye, lekin yeh bhee darshaata haye kii paridhiya tantrika tantra kaa praarambhik vikas maig kii upasthiti key binaa bhee apekshaakrit samanya haye. nockout choohon mein aam taur parr kaee motor kamee dikhaai detee hain, halanki, kyonki way myelinated akshtantuon key apakshay key kaaran umr badhane key kaaran aavaran key rakharkhaav mein inn glycoprotein kii aavashyakta kaa sujhaav dete hain.
jabaki yeh abhee bhee spasht naheen haye kii sateek tantra yaa maarg jisake dwara maig myelination koo prabhaavit kartaa haye, adhyayanon seey pataa chalata haye kii maig ack receptor bhoomika mein kaary kartaa haye taaki ack baahari srot seey sakriyan dwara shuru kiye gaye sanket cascade koo shuru kiya jaa sakey. maig koo akshatantu satah parr ack receptor key liye ack ligand key roop mein baandhate hue bhee dikhaaya gayaa haye joe bataata haye kii mylin key nirmaan koo sakriya karane vaalaa baahari uttejana tantrika koshika yaa koshikaon seey aatee haye jisase yeye glycoprotein bandhe hotey hain.
maig antibody.
shareer dwara antibody banaae jaate hain joe taba myelin seey judey glycoprotein key kaary parr hamla curr sakate hain aur baadhit curr sakate hain. yeye antibody glycoprotein key baahari kshetra seey judate hue paae gaye hain aur kissy bhee anya sanket koo honey seey rokte hain. choonki yeye protein vibhinn sanket cascades mein mahatvapurna hain joe antatah schwen koshikaon koo mylin banaane kaa kaaran banate hain, yeye antibody mool roop seey mylin nirmaan koo rokte hain joe neuropathy kii or leey jaataa haye. haalaanki, inn antibody key nirmaan key vaastavik kaaran key baare mein abhee bhee bahut bahas haye. kuchh shodh yeh sujhaav dene key liye kiye gaye hain kii yeye antibodies amyeloidosis key vibhinn roopon seey judey hue hain kyonki amyeloidosis key rogiyon koo uchch anty-maig antibodies kaa anubhav hotaa haye joe aamtaur parr neuropathy key ack roop kii or leey jaataa haye. haalaanki, yeh antibody key nirmaan key peechhe key tantra key roop mein koee saboot pradaan naheen kartaa haye.
lakshan aur sanket.
aam.
iss bimari vaale logon mein kaee samvedi aur maanspeshiyon key lakshan dikhaai diye hain. adhikansh rogiyon mein samvedi akshata, yaa vibhinn chhoron mein samvedi haani hoti haye, saath hii halki seey madhyam maanspeshiyon kii kamjori hoti haye, joe aamtaur parr pair kii ungaliyon aur ungaliyon seey shuru hoti haye aur ander kii or badhati haye. adhikansh rogi charam seemaon mein halke seey madhyam jhatake bhee pesh karate hain joe roga key badhane key saath badhata haye.
gambhir.
roga key badhane key baad adhik gambhir lakshan hotey hain aur paridhiya tantrika tantra mein mylin aavaran koo bahut adhik nuksan hotaa haye. yeye kamjor karane vaale compans key roop mein prastut hoe sakate hain joe rogiyon koo samanya kaary karane seey rokte hain, angon parr poorna samvedi haani, aur kuchh mamalon mein, vyaapak maanspeshiyon kaa kshay.
nidan.
iss prakaar kii neuropathy kaa pataa lagaane mein jyaadaatar antibody kii upasthiti kaa pataa lagaane parr dhyaan kendrit kiya gayaa haye kyonki antibody roga kaa mukhya kaaran hain. vibhinn prakaar key parakh kaa upayog karke rogi key seera mein anty-maig antibody kaa aasaani seey pataa lagaaya jaa sakata haye, lekin mukhya roop seey ack elissa koo sabse prabhaavi dikhaaya gayaa haye. vibhinn javic sanketak bhee hain, jaise kii mastishk reedh kii huddy key taral padaarth key uchch star aur unnat pratimaan monoclonal star. inca pareekshan yaa tou rogi seey seeram nikalkar yaa reedh kii huddy key null seey reedh kii huddy kaa taral padaarth nikalkar aur parakh yaa dhabbon kaa upayog karke kiya jaa sakata haye.
upchaar.
iss bimari seey ladane key liye dawa aur chikitsiya upchaar maujood hain; haalaanki kaee aprabhaavi saabit hue hain.
immunotherapy aur chemotherapy.
jabaki immunotherapy kuchh rogiyon key liye mamuli lakshnon seey raahat dene mein kaam karati haye, steroid, immunospressant, chemotherapy aur intravinus immunoglobulin therapy kaa upayog karane vaale samagr roop seey adhikansh paaramparik upchaaron ney adhikansh rogiyon kii madad naheen kii haye. isase nae aur adhik nae upchaaron koo vikasit karane kii aavashyakta paida hui haye.
chlorambucil aur prednisone.
chlorambucil ack chemotherapy dawa haye jiska upayog aamtaur parr leukemia key ilaaj key liye kiya jaataa haye kyonki iska upayog aksar ack immunospressant dawa key roop mein kiya jaataa haye, aur prednisone ack steroid haye joe ack immunospressant key roop mein vishesh roop seey prabhaavi paaya gayaa haye. adhikansh rogiyon mein davaaon key iss sanyojan kaa koee laabh naheen haye, lekin ack chhoti sankhya mein cumm jhatake jaise chhote sudhaar dikhaai dete hain. yeh sanyojan adhik gambhir mamalon mein bahut prabhaavi naheen rhaa haye, halanki, aur ise deerghakaalik chikitsa naheen maanaa jaataa haye.
cyclophosphamide.
cyclophosphamide ack dawa haye jiska upayog aksar lymphoma key upchaar mein kiya jaataa haye aur yeh koshika key vikas koo dheema yaa rokkar kaam karati haye. yeh vibhinn beemariyon aur sthitiyon key liye shareer kii pratiraksha pratikriya koo cumm karke ack pratiraksha daman key roop mein bhee kaam kartaa haye. yeh dawa samvedi haani seey raahat dekar aur kuchh hii maheenon mein jeevan kii gunavatta mein sudhaar karane mein madad karke anty-maig neuropathy vaale logon mein mahatvapurna sudhaar karane key liye paaee gaee haye. haalaanki, iss upchaar key kaaran cancer kaa khatra haye aur isaliye iska niyamit roop seey upayog naheen kiya jaataa haye.
fluiderabin.
fluiderabin ack dawa haye jiska upayog aam taur parr hematological durbhavnaon key ilaaj key liye kiya jaataa haye aur yeh ack pratirakshaatmak daman key roop mein kaary karati haye. yeh neuropathy rogiyon mein sthitiyon mein kaafee sudhaar karane key liye dikhaaya gayaa haye, lekin adhyayan kii kamee key kaaran iska niyamit roop seey upayog naheen kiya jaataa haye. sambhaavit vishaaktata kaa bhee khatra haye kyonki upchaar mein rogi koo sthir honey mein ack saal kaa samay lagata haye.
antahshira immunoglobulin.
antahshira immunoglobulin ack rakt utpaad haye jise IV dwara prashaasit kiya jaataa haye. iska upayog vibhinn pratiraksha kamiyon aur autoimmune rogon key ilaaj key liye kiya jaataa haye. jabaki yeh vibhinn prakaar key vikaaron parr prabhaavi dikhaaya gayaa haye, aisaa koee adhyayan naheen huaa haye joe anty-maig neuropathy kaa ilaaj karane vaali iss takneek mein vaadaa dikhaata haye.
sabse ashajanak davaah retooksimab.
retooksimab koo anty-maig paridhiya neuropathy key upchaar mein sabse ashajanak davaaon mein seey ack maanaa jaataa haye. yeh dawa ack protein key khilaf ack antibody haye joe mukhya roop seey bee koshikaon kii satah parr paaee jaati haye, joe jaba judee hoti haye, tou bee koshikaon koo nasht curr detee haye. iss dawa kaa upayog kaee autoimmune rogon key saath-saath lymphoma aur pratyaropan asweekriti mein upchaar key roop mein kiya gayaa haye. pratiraksha pranali koo dabaane kii isaki kshamata key kaaran, iska upayog anty-maig neuropathy key ilaaj key liye iss ummeed mein kiya gayaa haye kii yeh una koshikaon koo nasht curr dega joe shwan koshikaon parr aavashyak glycoprotein koo lakshit karengi. rogiyon mein kiye gaye adhyayanon seey pataa chalaa haye kii adhikansh rogiyon koo chikitsa key pahale kuchh maheenon key bheetar samvedi aur motor kshamataon mein ullekhaniya vriddhi kaa anubhav hotaa haye. haalaanki, deerghakaalik adhyayanon seey pataa chalaa haye kii retooksimab key saath upchaar kaee pratiraksha samasyaaen paida curr sakata haye. adhikansh pratirakshaatmak davaaon key saath, anya sankramanon kaa khatra hotaa haye aur roga joe aam taur parr pratiraksha pranali dwara aasaani seey ladey jaate hain, unhein pair jamaane kii anumati dee jaayegi. adhyayanon seey pataa chalaa haye kii lambe samay taka upchaar key baad, rogiyon koo inmein seey kaee samasyaon kaa anubhav hotaa haye aur saath hii unaki tantrika vikriti mein girawat aatee haye. isake kaaran dawa kii suraksha profile aur upchaar key roop mein samagr prabhavsheelta parr aage key adhyayan kiye jaa rahey hain.
durbhagya seey, haal key adhyayanon ney nishkarsh nikala haye kii "retooksimab roga-rodhi demilinating neuropathy vaale rogiyon mein samasya mein sudhaar karane mein aprabhaavi haye."
vartamaan shodh.
vartamaan shodh ney jyaadaatar upchaar vikalpon koo nirdhaarit karane parr dhyaan kendrit kiya haye. iska adhyayan pahale soochibaddh davaaon key saath naidaanik parikshanon key madhyam seey yaa naee chikitsa takneekon key madhyam seey kiya gayaa haye joe kaary mein kamee mein deree karati hain. adhyayan kii jaa rahee adhikansh davaaen pratirakshaatmak hain joe schwen koshikaon koo nuksan seey bachaane kii ummeed mein antibody yaa anya pahaluon parr hamla curr sakati hain. yeh, aadarsh roop seey, paridhiya tantrika tantuon parr myelination key nuksan koo rokega.