
saha-sanrakshak

saha-chepron protein hain joe protein folding aur anya karyon mein chepron kii sahaayata karate hain. saha-chaperon gair-client bandhan anu hain joe aich. aiss. pee. 70 aur aich. aiss. pee. 90 dwara madhyasthata kiye gaye protein folding mein sahaayata karate hain. way vishesh roop seey inn chaperon protein kii atpage gatividhi kii uttejana mein aavashyak hain. vibhinn saha-sanrakshkon kii ack badee sankhya haye, halanki unaki domen sanrachana key aadhar parr unamen seey adhikansh dou samoohon mein aatey hainh jey-domen protein aur tetratricopiptide repeats (tii. pee. aar.).
saha-chaperon protein koo modane kii prakriya mein garmi key shock protein kii sahaayata karate hain. yeye saha-sanrakshak kaee tarikon seey kaary curr sakate hain. mukhya roop seey saha-upagrahiya apane sambandhit ooshmaa aghaat protein kii gati-charan karyakshamta mein shamil hotey hain. saha-chaperon apane-apane chaperon parr jall apghatan koo utprerit karate hain joe unhein ack badey anuroop parivartan seey gujarane detaa haye joe unhein yaa tou uchch aatmiyata key saath apane substrate seey baandhane yaa protein folding key baad substrate key release mein sahaayata karane kii anumati detaa haye, jaisa kii saha-chaperon pee 23 key mamle mein hotaa haye.
jey-protein, dee. aine. aeye. jee. yaa aich. aiss. pee. 40. aich. aiss. pee. 70. key liye mahatvapurna saha-chepron hain aur polypeptides seey judane kii kshamata rakhate hain aur phir chepron protein dee. aine. aeye. key. kii bharti karate hain aur polypeptide koo iss chepron mein utprerit karke paarit karate hain. ack anya saha-chaperon, grip, iss protein key taha key baad aataa haye joe danak mein ack anuroop parivartan kaa kaaran banata haye joe ise mudey hue protein koo chhodane kii anumati detaa haye. tii. pee. aar. protein key tantra kaa cumm adhyayan kiya gayaa haye inn kshetron koo aich. aiss. pee. 90 aur aich. aiss. pee. 70 key saath baatchit karane key liye dikhaaya gayaa haye aur ack aich. aiss. pee. 70-aich. aiss. pee. 90 bahu-chaperon parisar key nirmaan mein shamil hoe sakata haye.
saha-capron cystic fibrosis jaisi beemariyon koo galat tareeke seey modane mein bhee mahatvapurna bhoomika nibha sakate hain. aich. aiss. pee. 90 aur isake saha-chaperon, aeye. aich. aeye. 1 key beach ack antahkriya, cystic fibrosis transmembrane chaalan niyaamak (see. aff. tii. aar.) key uchit taha key liye aavashyak haye. bimari mein saha-chepron kii bhoomika key anya udaharanon mein neurodegenerative roga shamil hain. alzheimer aur parkinsons roga mein kaee protein hotey hain joe thheek seey cumm naa honey parr ekatra hoe sakate hain. saha-chaperon see. aiss. pee. aeye. (dee. aine. aeye. jee. see. 5), auxilin (dee. aine. aeye. jee. see. 6) aur aar. aim. ee.-8 (dee. aine. aeye. jee. see. 13) taha aur sanyojan koo sanrakshit karane key liye mahatvapurna hain, isaliye protein ektrikaran koo rokte hain. inn proteins mein utparivartan kaa pataa lagaane kaa sambandh neurodegenerative rogon kii praarambhik shuruat seey haye.