
pdlim3

actin-associated lima protein (ell. pee.), jise pee. dee. jaid. aur lima domen protein 3 key roop mein bhee jaanaa jaataa haye, ack protein haye jise manushyon mein "pee. dee. ell. aaee. aim. 3" jeane dwara kootbaddh kiya jaataa haye. elp hriday aur kankal kii maanspeshiyon mein atyadhik vyakt kiya jaataa haye, jahan yeh jaid-disk aur interclated disk mein sthaaniyakrit hotaa haye. alfa-aiktinin-2 dwara actin key cross linking koo badhaane key liye lp kaary aur sahee nilay kaksh gathan aur sankara kaary key liye bhee aavashyak prateet hotaa haye.
sanrachana.
elp mukhya roop seey dou vaikalpik roop seey vibhajit roopon key roop mein maujood haye; kankal kii maanspeshiyon mein ack 39.2 kda (364 emino acid) protein aur hriday kii maanspeshiyon aur chikani maanspeshiyon mein ack 34.3 kda (316 emino acid) protein. ell. pee. mein ack aine-terminal pee. dee. jaid. domen aur ack see-terminal lima domen haye. isake alawa, aalp upa-parivaar mein ack vishisht 34 emino acid domen hotaa haye jise aalp-jaise rupankan naam diyaa gayaa haye, jisamen protein kinnez see sarvasammati anukram hotey hain. aalp kaa pee. dee. jaid. kshetra alfa actinine-2 seey judataa haye, vishesh roop seey isake spectrin jaise dohrao key liye. pee. dee. jaid. kshetra chaar avashisht jee. ell. jee. aff. anukramon key saath 80-120 emino acid seey banaa ack rupankan haye joe aamtaur parr cytoskeletal protein key see-terminal key saath baatchit kartaa haye. dou samroopon mein vishamta kaa kshetra pee. dee. jaid. domen aur lima domen key beach haye. ell. pee. gunasutra 4kyu35 mein sthaaniyakrit haye. yeh dikhaaya gayaa haye kii choohon mein maanspeshiyon key andh jaise 1 kaa vilopan "pee. dee. ell. aaee. aim. 3" key vibhajan pattern koo badal sakata haye.
kaary.
adhyayanon seey pataa chalaa haye kii elp myophybrillogenesis key pahale charan mein maujood haye jahaan yeh alfa actinine-2 seey bandha huaa haye, aur yeh sambandh paripakva myophibrils mein barkarar rahata haye jahaan elp koo jaid-disk aur interclated disk key liye sthaaniyakrit kiya jaataa haye. haalaanki, alfa actin-2 koo ell. pee. seey jaid-lines koo lakshit karane key liye aavashyak naheen haye. elp nockout choohon mein kiye gaye adhyayanon seey pataa chalaa haye kii elp, alfa actinine-2 dwara actin tantuon koo cross-linking kii suvidha pradaan kartaa haye, aur elp kii anupasthiti asamanya daahine nilay kaksh gathan, dysplasia aur cardiomyopathy koo prerit karati haye. inn jaanvaron mein sahee nilay epicardial systolic strain aur jyaamitiya punarnirmaan vishleshan kaa upayog karke aage key adhyayanon seey pataa chalaa kii elp kii anupasthiti sahee nilay sankshepan kaary koo cumm karati haye aur cardiac hypertrophic punarnirmaan key pattern koo badal detee haye. collegen nikshepan yaa aantarik aerobic chalane kii kshamata (chaap) key aanuvanshik parivartakon kii jaanch karane key liye ekikrit genomic drishtikon kaa upayog karane vaale dou adhyayanon ney sambandhit matratmak visheshta sthaan key liye "pdlim3" koo mapp kiya haye, joe sujhaav detaa haye kii inn hriday ghatnaaon seey sambandhit aanvik network mein lp shamil hoe sakata haye.
naidaanik mahatva.
gunasutra 4 pericentric vyutkram 10 rogiyon mein dekhaa gayaa haye, jisamen terminal 4q35.1 vilopan seey judey hriday dosh hain, joe "pdlim3" koo prabhaavit curr sakate hain.
antahkriyaaen.
ell. pee. key saath antahkriya kartaa haih

