alfa-parinaric acid

α-parinaarik acid ack sanyugmit bahuasantript vasaa acid haye. 1933 mein tsujimoto aur koyanagi dwara khoje gaye, isamen 18 carbon paramanu aur 4 sanyugmit dohare bandhan hain. α-parinaric acid kii doharaae jaane vaale ekal bandhan-dohare bandhan sanrachana ise sanrachanaatmak aur rasayanik roop seey polyunsaturated fatty acid kii samanya "mithileen-baadhit" vyavastha seey alag karati haye jisamen dohare-bandhan aur ack ekal bandhan hotey hain joe ack mithileen ikai (−ch2−) dwara alag kiye jaate hain. vaikalpik dohare bandhanon dwara pradatt pratideepti gunon key kaaran, α-parinaarik acid kaa upayog aamtaur parr biomembrane key adhyayan mein aanvik jaanch key roop mein kiya jaataa haye.
praakritik srot.
α-parinaarik acid praakritik roop seey makita pedh ("parinari laurina") key beejon mein paaya jaataa haye, joe kii fiji aur anya prashant dweepon mein paaya jaane vaalaa ack pedh haye. makita key beejon mein lagbhag 46 pratishat α-parinaarik acid, 34 pratishat α-allostearic acid pramukh ghatakon key roop mein hotaa haye, jisamen cumm matra mein santript vasaa acid, olic acid aur linolic acid hotaa haye. α-parinaric acid "impetins balsamina" key beej tail mein bhee paaya jaataa haye, joe "balsaminacy" parivaar kaa ack sadasya haye. impetins balsamina" key pramukh vasaayukt aml 4.7% palmitic aml, 5.8% stearic aml, 2.8% arakidic aml, 18.3% olic aml, 9.2% linolic aml, 30.1% linolenic aml aur 29.1% α-parinaarik aml hain. yeh kavak "clavulina christata" aur paudhe "sebastiana brasiliansis" (parivaar euphorbiacy) mein bhee maujood haye.
sanshleshan.
jaiv sanshleshan.
javic rasayan tantra jisake dwara paudhe mein α-parainarik acid banata haye, "impatience balsamina" koo aanvik jeev vigyaan kii takneekon kaa upayog karke vistrit kiya gayaa thaa. sanyugmit dohare bandhan key nirmaan key liye jimmedaar enzyme kii pehchaan vyakt anukram tagg kaa upayog karke kii gaee thee, aur ise "sanyugma" kahaa jaataa thaa. yeh enzyme fatty acid desatures enzymon key parivaar seey sambandhit haye joe fatty acid mein dohare bandhan lagaane key liye jimmedaar haye.
rasayanik sanshleshan.
α-parinaarik acid koo praarambhik yaugik key roop mein α-linolic acid kaa upayog karke rasayanik roop seey sanshleshit kiya jaa sakata haye. yeh sanshleshan praakritik roop seey paae jaane vaale polyunsaturated fatty acid key 1,4,7-octatrine mithileen-baadhit "sis" dohare bandhan koo uchch upaj mein 1,3,5,7-octatrain mein badalane mein saksham banaata haye. haal hii mein (2008), lii aitt all. ack modular design vidhi kaa upayog karke ack saral aur kushal rasayanik sanshleshan kii soochana dee jise iterative cross-coupling kahaa jaataa haye.
upayog karein.
jhilli jaanch.
parinaric acid key alfa aur beeta (sabhi "trance") isomer donon kaa upayog lipid-lipid antahkriyaon key aanvik jaanch key roop mein kiya jaataa haye, joe dwi-parat lipid jhilli mein charan sankraman kii nigrani kartaa haye. α-parinaric acid koo standhari koshikaon, tantrika ootak key phospholipid dwi parat mein samanya roop seey ekikrit karane key liye dikhaaya gayaa thaa, jisamen jhilli key jaivbhautikiya gunon parr nyuntam prabhaav padata haye. padosi jhilli lipid key saath aanvik antahkriya anumaanit tarikon seey α-parinaric acid key pratideepti koo prabhaavit karegi, aur oorjaa kii teevrata mein baad key sookshm parivartanon koo spectroscopic roop seey maapa jaa sakata haye.
shodhkartaon ney jhilli jaivbhautiki key adhyayan mein α-parinaric kaa achchha upayog kiya haye. udaaharan key liye, iska upayog kuchh tumour koshikaon kii jhilli kii dwistariya parat mein "taralata pravanata" key astitva koo sthaapit karane mein madad karane key liye kiya gayaa thaa-jhilli kii aantarik ekasthaitik parat baahari ekasthaitik parat kii tulanaa mein cumm taral hoti haye.
lipid-protein antahkriya.
α-parinaric acid kaa upayog jhilli protein aur lipid key beach baatchit kaa adhyayan karane key liye ack kromophore key roop mein bhee kiya jaataa haye. samanya jhilli lipid key saath α-parinaric acid kii samaantaa key kaaran, iska nyuntam vichalit karane vaalaa prabhaav hotaa haye. avashoshan spectrum mein badalaav koo maapane, α-parinaric acid pratideepti kii vriddhi, prerit golakar dwiroopata, aur protein aur baadhya kromophore mein tryptophan emino acid key beach oorjaa hastaantaran, protein aur lipid key beach aanvik baatchit key baare mein jaankaari praapt kii jaa sakati haye. udaaharan key liye, iss takneek kaa upayog yeh jaanch karane key liye kiya jaataa haye kii kaise fatty acid seeram albumin (ack atyadhik prachur matra mein rakt protein), lipid parivahan prakriyaon key saath lipoprotein key sanrachanaatmak lakshan varnan aur phospholipid-hastaantaran protein seey judate hain.
naidaanik upayog.
rakt seeram yaa plasma mein fatty acid kii sandrata koo α-parinaric acid kaa upayog karke maapa jaa sakata haye, joe seeram albumin parr bandhan sthalon key liye pratispardha karega.
khaadya rasayan.
α-parinaric acid kaa upayog khaadya protein kii hydrophobicity aur phome visheshtaon key saath-saath bear kii phome sthirata kaa adhyayan karane key liye kiya gayaa haye. iss baad key shodh mein, α-parinaric acid kaa upayog bear mein protein kii lipid-binding kshamata kaa aaklan karane key liye ack pratideepti parakh mein kiya gayaa thaa, kyonki yeye protein bear koo phome-cumm karane vaale madhyam aur lambi shrinkhala vaale fatty acid seey bachaane mein madad karate hain.
tumour koshikaon parr cytotoxic prabhaav.
α-parinaric acid koshika samvardhan mein 5 microne yaa usase cumm kii sandrata parr maanav leukemia koshikaon key liye cytotoxic haye, tumour koshikaon koo lipid peroxidation key liye samvedansheel banaakar, vaha prakriya jahaan mukt kann koshika jhilli lipid seey electrons key saath pratikriya karate hain, jisake parinamswarup koshika kshati hoti haye. yeh koshika samvardhan mein ugaaye jaane vaale ghaatak glioma key liye isi tarah seey cytotoxic haye. culture mein ugaaye jaane vaale samanya (gair-tumour) astrocytes α-parinaric acid key cytotoxic prabhaavon key prati bahut cumm samvedansheel hotey hain. tumour koshikaon key prati yeh adhimanya vishaaktata see-juna aine-terminal kinnez key antar viniyaman aur ghaatak aur samanya koshikaon key beach forkhead pratilekhan karakon key kaaran haye.

