
foxje1

forkhead boxes protein jey1 ack protein haye jise manushyon mein "foxje1" jeane dwara kootbaddh kiya jaataa haye. yeh pratilekhan karakon key kantedar/pankhon vaale helix (lomdi) parivaar kaa ack sadasya haye joe siliogenesis mein shamil haye. foxje1 fefadon kii ciliated koshikaon, coroid plexus, prajanan path, bhroon gurde aur poorv-somite bhroon charan mein vyakt kiya jaataa haye.
jeane kaa sthaan.
maanav "foxje1" jeane gunasutra 17, kshetra 2, baind 5, upa-baind 1 kii lambi bhuja parr sthit haye.
sanrachana.
foxje1 mein ack sanrakshit 100 emino acid lamba dna binding domen haye.
kaary.
yeh jeane pratilekhan karakon key forkhead parivaar key ack sadasya koo kootbaddh kartaa haye. zebrafish aur choohe mein samaan jeane koo gatishil siliya key utpaadan koo niyantrit karane vaale jeane key pratilekhan koo niyantrit karane key liye dikhaaya gayaa haye. mouse orthologue bhee baaen-daaen vishamta key nirdhaaran mein kaary kartaa haye.
siliogenesis.
praathamik siliogenesis foxje1 parr nirbhar haye aur yeh pratilekhan kaarak gatishil ciliated koshika vibhedan key liye aavashyak haye. foxje1 abhivyakti kii shuruat gatishil ciliated koshikaon key banane key liye koshikaon kaa sanket haye. koshikaaen foxje1 sakriyan seey pahale siliogenesis kii or badhati hain. sakriyan besal shareer kii taskari koo badhaava detaa haye, epical jhilli parr docking aur baad mein exonum vriddhi koo badhaava detaa haye. pee53 protein parivaar kaa ack sadasya protein pee73 seedhe "foxje1" koo niyantrit kartaa haye aur ciliated koshika gathan key liye ack aavashyakta haye. foxje1" key 10,000beepi lambe pratilekhan praarambh sthal mein pee73 key liye teen anukram vishisht bandhan sthal hain.
pratiraksha pranali.
standhari koshikaon mein, foxje1 koo nfkb koo dabaane key liye dikhaaya gayaa haye, joe pratiraksha pratikriya mein ack pramukh niyaamak haye aur bee-koshikaon mein haasya pratikriya koo bhee rokta haye. yeh aine. aff. key. bee. key ack avarodhak ghatak key viniyaman key madhyam seey hotaa haye jise aaee. key. bee. bee. aeye. aur aaee. ell.-6 kahaa jaataa haye.
vikas.
foxje1 koo bhroon key vikas key dauran daanton key ankuran, tamchini, maukhik aur jeebh upkala key gathan aur upa-mandibular laar granthiyon aur baalon key romon key gathan key sambandh mein vibhinn binduon parr vyakt kiya jaataa haye. foxje1 abhivyakti kii anupasthiti protease calpain key avarodhak calpastatin koo cumm curr detee haye. calpain disregulation akshatantu gathan koo prabhaavit karane vaale epical cytoskeleton key liye besal shareer lunger koo prabhaavit kartaa haye. foxje1 kii abhivyakti koo il-13 dwara baadhit kiya jaataa haye.
naidaanik mahatva.
iss jeane mein bahuroopata pranaaleegat lupus erythematosus aur allergies nasika shoth seey judee hoti haye.
shwasan pranali key viral sankramanon seey foxje1 kii abhivyakti cumm hoti haye. yeh siliogenesis koo prabhaavit kartaa haye aur mucosillary kriya koo prabhaavit kartaa haye.
stun cancer.
maanav stun ootak rekhaaon aur praathamik stun tumour key adhyayanon mein paaya gayaa haye kii jeane "foxje1" praathamik tumour mein asamanya roop seey atee-methyl hain. yeh hypermethyltion foxje1 protein key utpaadan koo shaant karane kaa kaam kartaa haye aur tumour key gathan mein ack sambhaavit mahatvapurna ghatana key roop mein prastaavit kiya gayaa haye.
gurde kii koshika kaa cancer saaf karein.
foxje1 abhivyakti koo spasht koshika gurde key carcinoma rogiyon mein aur tumour charan, ootakiya grade aur tumour key aakar kaa sanket dene key liye unnat dikhaaya gayaa haye. see. aar. see. see. rogiyon mein foxje1 kii uchch abhivyakti kharaab purvanuman seey judee thee. foxje1 mein see. aar. see. see. rogiyon key liye ack oncogene marker key roop mein kaary karane kii kshamata haye aur iska ack chikitsiya lakshya key roop mein moolya haye.
exenfeld-reeger syndrome.
exenfeld-reeger syndrome key rogiyon mein "foxje1" jeane key niyaamak protein pitex2 mein ack bindu utparivartan hotaa haye. leif-1 aur beeta-catanine key saath pitex2 "foxje1" koo niyantrit kartaa haye. foxje1 badale mein ack sakaratmak pratikriya tantra banaane key liye pitex2 key saath baatchit kartaa haye. pitex2 bindu utparivarti mein jabaki foxje1 key saath baandhane mein saksham honey mein "foxje1" pravartak koo sakriya karane kii kshamata kaa abhaav hotaa haye, isake parinamswarup anuchit or-facial morphogenesis ars mein ack kaarak hotaa haye.
hydrocephalus.
iss jeane mein utparivartan ack autosomal dominant syndrome seey judey hue hain jisamen hydrocephalus aur baaen/daaen shareer kii vishamta kaa yaadrichhikkaran shamil haye.

