
etoposide

etoposide, jise anya logon key beach vapacid brand naam key tahat becha jaataa haye, ack chemotherapy dawa haye jiska upayog vrishan cancer, fefadon key cancer, lymphoma, leukemia, neuroblastoma aur dimbagranthi key cancer sahit kaee prakaar key cancer key upchaar key liye kiya jaataa haye. iska upayog haemophagocytic lymphohystiocytosis key liye bhee kiya jaataa haye. iska upayog munh yaa nus mein injection dwara kiya jaataa haye.
dushprabhaav bahut aam hain. inmein cumm rakt koshika ginati, ulti, bhookh naa lagana, dast, baal jhadana aur bukhaar shamil hoe sakate hain. anya gambhir dushprabhavon mein allergy pratikriyaen aur nimn raktchaap shamil hain. garbhavastha key dauran upayog seey bhroon koo nuksan honey kii sambhavana haye. etoposide dawa key topoisomerase avarodhak parivaar mein haye. aisaa maanaa jaataa haye kii yeh dee. aine. aeye. koo nuksan pahunchaakar kaam kartaa haye.
sanyukt raajya america mein 1983 mein chikitsa upayog key liye etoposide koo manjuri dee gaee thee. yeh vishva swaasthya sangathan kii aavashyak davaaon kii soochi mein haye.
chikitsa upayog.
etoposide kaa upayog caposi sarcoma, eaving sarcoma, fefadon key cancer, vrishan cancer, lymphoma, gair-lymphocytic leukemia aur glioblastoma multiform jaise cancer key liye chemotherapy key roop mein kiya jaataa haye. yeh aksar anya davaaon key saath sanyojan mein diyaa jaataa haye (jaise kii vrishan cancer key ilaaj mein bliomycin). iska upayog kabhi-kabhi asthi majja yaa rakt stame cell pratyaropan seey pahale ack conditioning aahar mein bhee kiya jaataa haye.
prashaasan.
yeh antahshira (iv) yaa maukhik roop seey capsule yaa goli key roop mein diyaa jaataa haye. yadi dawa dee jaati haye, tou ise 30 seey 60 minut kii avadhi mein dheere-dheere kiya jaanaa chaahiye kyonki yeh raktchaap koo cumm curr sakata haye kyonki ise diyaa jaa rhaa haye. infusing key dauran aksar raktchaap kii jaanch kii jaati haye, prashaasan kii gati key anusaar samaayojit kiya jaataa haye.
dushprabhaav.
aam hainh
cumm aam hainh
jaba warfarin diyaa jaataa haye, tou yeh raktasraav kaa kaaran bunn sakata haye.
pharmacology.
kaarravaai kaa tantra.
etoposide dee. aine. aeye. aur topoisomerase II enzyme key saath ack trikoniya parisar banaata haye, joe ack enzyme haye joe dee. aine. aeye. mein nakaratmak yaa sakaratmak supercoil koo aaraam dene mein sahaayata kartaa haye. topoisomerase II aam taur parr ack dna double-strand mein double-stranded break banaayega, dusare koo gujarane dega, aur toote hue strand koo phir seey ligate karega. etoposide kaa bandhan topoisomerase II koo toote hue dna strand koo phir seey seemit karane seey rokta haye, jisase topoisomerase II dwara banaae gaye dna tootane kaa kaaran banata haye, aur topoisomerase II anu koo site chhodane aur kaheen aur tanaav seey raahat dene seey bhee rokta haye. isake parinamswarup dee. aine. aeye. mein ack double-strand break hotaa haye joe koshika parr vibhinn hanikarak prabhaav daal sakata haye, aur aage key tanaav koo door karane key liye upalabdh topoisomerase II kii kamee hoe sakati haye. cancer koshikaaen swasth koshikaon kii tulanaa mein iss enzyme parr adhik nirbhar karati hain, kyonki way adhik teji seey vibhajit hoti hain. isaliye, yeh dee. aine. aeye. sanshleshan mein trutiyon kaa kaaran banata haye aur cancer koshika key apoptosis koo badhaava detaa haye.
rasayan vigyaan.
etoposide jangli mandrake ("podophilum peltatam") key prakand seey podophylotoxin kaa ack ardhsanshleshak vyutpann haye. vishesh roop seey, yeh ack-glucose vyutpann key saath podophylotoxin kaa ack glycoside haye. yeh rasayanik roop seey cancer-rodhi dawa teneposide key samaan haye, jise kewal ack methyl samooh dwara alag kiya jaa rhaa haye jahaan teneposide mein ack thynil hotaa haye. inn donon yaugikon koo podophylotoxin key cumm vishaakt vyutpann banaane key uddeshya seey vikasit kiya gayaa haye.
yeh padaarth safed seey peele-bhoore rung kaa, kristaliya pouder hotaa haye. yeh carbonic vilayakon mein ghulansheel haye.
iska upayog isake namak atoposide phosphat key roop mein kiya jaataa haye.
itihas.
etoposide koo pahali baar 1966 aur yuu mein sanshleshit kiya gayaa thaa.aiss. khaadya aur aushadhi prashaasan koo 1983 mein manjuri dee gaee thee.
upnaam vee. pee.-16 sambhavatah una rasaayanvidon mein seey ack key antim naam key sanyojan seey aataa haye jinhone dawa (wonn wartberg) aur podophylotoxin parr praarambhik kaam kiya thaa. ack anya vaigyaanik joe podophylotoxin-adharit chemotherapeutics key vikas mein abhinn thaa, vaha thaa chikitsa pharmacologist hartman aff. stehlin.

