
mett-encaflin

mett-encaflin, jise metainkeflin (inn) key roop mein bhee jaanaa jaataa haye, jise kabhi-kabhi opioid vriddhi kaarak (ogf) key roop mein jaanaa jaataa haye, ack praakritik roop seey honey vaalaa, antarjanit opioid peptide haye jisamen apekshaakrit cumm avadhi kaa opioid prabhaav hotaa haye. yeh encaflin key dou roopon mein seey ack haye, doosara lyu-encaflin haye. anya antarjanyukt opioid parr site key liye unaki uchch shakti aur chayanaatmaktaa key kaaran encaphaline koo δ-opioid receptor kaa praathamik antajan ligand maanaa jaataa haye.
itihas.
mett-encaflin kii khoj aur visheshta johnn huges, hains coasterlitz, "aitt all" dwara kii gaee thee. 1975 mein opioid receptors key antarjanit ligand kii khoj key baad.
rasayan vigyaan.
mett-encaflin amino acid anukram tyre-gly-gly-phee-mett key saath ack pentapeptide haye. sthiti 1 parr tyrosine avashesh koo morphin parr 3-hydroxyl samooh key samaan maanaa jaataa haye.
jaiv rasayan.
vitaran.
mett-encaflin mukhya roop seey adhivrikk medula aur poore kendriya tantrika tantra (see. aine. aiss.) mein paaya jaataa haye, jisamen stratum, cerebral cortex, ghraan tubercle, hippocampus, septum, thalamus aur periaquiductal gray key saath-saath reedh kii huddy key prishthiya horn shamil hain. yeh paridhi mein bhee maujood haye, vishesh roop seey kuchh praathamik sahayak tantuon mein joe shroni visara koo uttejit karate hain.
jaiv sanshleshan.
mett-encaflin koo proenkeflin seey proteolytic daraar key madhyam seey dou chayapachaya charanon mein sanshleshit kiya jaataa haye. proenkeflin aeye koo pahale dou tripsin jaise endopeptidase enzymon mein seey ack, prohormone convertage 1 (pc1) yaa prohormone convertage 2 (pc2) dwara cumm kiya jaataa haye; phir, parinami madhyavarti enzyme carboxypeptidase ee (cpe; pahale encaflin convertage (ec) key roop mein jaanaa jaataa thaa) dwara aur cumm kiya jaataa haye. proenkeflin aeye mein mett-encaflin key chaar anukram hotey hain (nimnalikhit sthitiyon menh 100-104; 107-111; 136-140; 210-214), aur isake parinamswarup, iska daraar ack saath mett-encaflin peptides kii chaar pratiyaan utpann kartaa haye. isake alawa, proenkeflin key anabolism key parinamswarup dou see-terminal-vistaarit mett-encaflin vyutpann, heptapeptide mett-encaflin-aarg-phey (261-267), aur octapeptide mett-encaflin-aarg-gly-lyu (186-193) mein seey pratyek kii ack prati kaa utpaadan hotaa haye, halanki way mett-encaflin key samaan tareeke seey opioid receptors koo prabhaavit karate hain yaa naheen, yeh poori tarah seey spasht naheen haye.
nikasi.
mett-aur lyu-encaflin vibhinn prakaar key enzymon dwara chayapachaya kiye jaate hain, jinamen aminopeptidase aine (apn), neutral endopeptidase (nape), dipeptidile peptidase 3 (dpp 3), carboxypeptidase aeye 6 (cpa 6), aur angiotensin-parivartit enzyme (aeye. see.) shamil hain. inn enzymon koo kabhi-kabhi encaphaliness key roop mein sandarbhit kiya jaataa haye.
javic gatividhi.
mett-encaflin δ-opioid receptor kaa ack shaktishali agonist haye, aur kuchh hudd taka microid-opioid receptor, jiska κ-opioid receptor parr bahut cumm yaa koee prabhaav naheen padata haye. inn receptors key madhyam seey hii mett-encaflin apane opioid prabhaavon kaa utpaadan kartaa haye, jaise kii analgesia aur avasaadarodhi jaise prabhaav.
yeh opioid vriddhi kaarak receptor (ogfr; pahale jise ζ-opioid receptor key roop mein jaanaa jaataa thaa) kaa antarjanit ligand bhee haye, joe ootak vikas aur punarjanan key viniyaman mein bhoomika nibhaata haye; isaliye mett-encaflin koo kabhi-kabhi ogf kahaa jaataa haye.
pharmacokinetics.
mett-encaflin mein cumm jaiv upalabdhata hoti haye, teji seey chayapachaya hotaa haye, aur iska aadhaa jeevan (minut) bahut cumm hotaa haye. inn gunon koo pharmaceuticals mein avaanchhaniya maanaa jaataa haye kyonki ack chikitsiya roop seey praasangik prabhaav banaae rakhane key liye badee khuraak koo ack ghante mein kaee baar prashaasit karane kii aavashyakta hogi, jisase yeh sambhavana naheen haye kii mett-encaflin kaa upayog kabhi bhee ack dawa key roop mein kiya jaayega.
[dee-alaa2]-mett-encaphalinamide (daala), ack synthetic encaphaline analogue haye joe mastishk enzymon dwara ksharan key liye atisamvedansheel naheen haye aur cumm khuraak (5 seey 10 microgram) parr choohe key mastishk mein microenject kiye jaane parr gahare, lambe samay taka chalane vaale, morphin jaise analgesia kaa kaaran banata haye.

