bee. aar. dee. tii.

bromodoman testis-vishisht protein ack protein haye jise manushyon mein "bee. aar. dee. tii" jeane dwara kootbaddh kiya jaataa haye. yeh bromodoman aur atirikt-antim rupankan (shart) protein parivaar kaa sadasya haye.
bee. aar. dee. tii. tii protein parivaar key samaan haye. isamen 2 bromodoman rupankanon aur ack keat anukram (proline, glutamic acid, serin aur thronin avasheshon kaa ack samooh) hotaa haye, joe protein kii visheshta haye joe teji seey antahkoshikiya ksharan seey gujarati haye. bromodoman protein mein paaya jaataa haye joe pratilekhan koo niyantrit karate hain. iss jeane key liye ack hii protein koo encoding karane vaale dou pratilekh roop paae gaye hain.
teen alag-alag mouse model (bee. aar. dee. tii. nock-out choohon, ack gair-karyatmak bee. aar. dee. tii. koo vyakt karane vaale choohon aur ack utparivartit bee. aar. dee. tii. koo apane pahale bromodoman kii kamee koo vyakt karane vaale choohon) key upayog seey pataa chalaa kii bee. aar. dee. tii. ack myotic aur post-myotic jeane abhivyakti karyakram koo chalaata haye. yeh genome-vyaapi post-myotic genome punargathan koo bhee niyantrit kartaa haye joe lambe shukranuon mein histone hyperacetylation key baad hotaa haye.
model jeev.
model jeevon kaa upayog bee. aar. dee. tii. kaary key adhyayan mein kiya gayaa haye. ack sashart nockout mouse line, jise "bee. aar. dee. tii. tii. aim. 1 aeye. (yucom) doubleu. tii. aiss. aaee." kahaa jaataa haye, antarrashtriya nockout mouse sangh karyakram key hisse key roop mein utpann kiya gayaa thaa-ack uchch-thruput utparivartan pariyojana joe ruchi rakhane vaale vaigyaanikon koo roga key pashu model utpann karane aur vitarit karane key liye haye.
narr aur maadaa jaanvaron koo hataane key prabhaavon koo nirdhaarit karane key liye ack maankeekrit phenotypic screen seey gujarna padaa. utparivarti choohon parr panchish pareekshan kiye gaye aur dou mahatvapurna asaamaanyataaen dekhi gaeen. samroopi utparivarti narr upa-upajaau they aur donon lingon mein cutty aur trick kasheruka kii sankhya mein kamee aaee thee.
purush garbhanirodhak dawa key lakshya key roop mein sambhaavit.
हैं। jaise shart avarodhak chromatin bandhan key liye jimmedaar brdt key kshetra koo avaruddh karate hain, aur choohe mein shukranu utpaadan, shukranu kii gunavatta aur vrishan key aakar mein prativarti kamee kaa kaaran banate hain.
हैं। kii kriya key tantra koo vrishan-vishisht jeane abhivyakti aur post-myotic chromatin punargathan key chaalak key roop mein brdt key karyon parr vichaar karke samajhaaya jaa sakata haye. choonki shart avarodhak anya shart protein bee. aar. dee. 2, bee. aar. dee. 3 aur bee. aar. dee. 4 koo bhee rokte hain, isaliye unake asthaayi purush baanjhapan seey parey logon mein prabhaav padane kii sambhavana haye.

