omveloxolone

omeloxolone, jise skycleries brand naam seey becha jaataa haye, ack dawa haye jiska upayog friedrich key attaxia key upchaar key liye kiya jaataa haye. ise munh seey liya jaataa haye.
sabse aam dushprabhavon mein elenin transaminase mein vriddhi aur aspartate aminotransferase mein vriddhi shamil haye, joe yakrit kshati, sirdard, matali, pett dard, thakan, dast aur musculluskeletal dard key sanket hoe sakate hain.
farwari 2023 mein sanyukt raajya america mein chikitsa upayog key liye omveloxolone koo manjuri dee gaee thee.
chikitsa upayog.
omeloxolone koo friedrich key attaxia key upchaar key liye sanket diyaa jaataa haye.
friedrich kaa attaxia reedh kii huddy, paridhiya tantrikaon aur mastishk koo pragatisheel kshati pahunchaata haye, jisake parinamswarup maanspeshiyon kii aniyantrit gati, kharaab santulan, chalane mein kathinaaee, bolane aur nigalane mein parivartan aur ack chhota jivankal hotaa haye. yeh sthiti hriday roga kaa kaaran bhee bunn sakati haye. yeh bimari bachchon aur kishoron mein vikasit hoti haye aur samay key saath dheere-dheere bigadati jaati haye.
halanki durlabh, sanyukt raajya mein vanshaanugat akshata kaa sabse aam roop friedrich kaa akshata haye, joe harr 50,000 logon mein seey lagbhag ack koo prabhaavit kartaa haye.
kaarravaai kaa tantra.
omveloxolone aur isake sambandhit yaugikon kii kriya kaa tantra antioxidative transcription kaarak aine. aar. aff. 2 key sakriyan aur pro-inflammatory transcription kaarak aine. aff.-key. bee. key nishedh key sanyojan key madhyam seey pradarshit kiya gayaa haye.
aine. aar. aff. 2 pratilekhan roop seey kaee jeenon koo niyantrit kartaa haye joe antioxidative kshamata aur cellular oorjaa key utpaadan mein pratyaksh aur apratyaksh donon bhoomikaaen nibhaate hain.ee.", adenosine trifosphate yaa aeye. tii. pee.) mitochondria key bheetar. natijatan, bahishkrit roop seey prashaasit antioxidant (ee.jee.", vitamin ee yaa coenzyme coenzyme, joe ack vishisht aur seemit antioxidative kshamata pradaan kartaa haye, omveloxolone, aine. aar. aff. 2 key madhyam seey, motey taur parr intracellular aur mitochondrial antioxidative maargon koo sakriya kartaa haye, isake alawa aise maarg joe seedhe mitochondrial biogenesis (jaise pee. jee. see. 1α) aur bioenergetics koo badhaa sakate hain.
itihas.
omaveloxolone synthetic olean triterpanoid yaugikon kii doosari peedhi kaa sadasya haye aur reeta pharmaceuticals dwara naidaanik vikas mein haye. preclinical adhyayanon ney pradarshit kiya haye kii omveloxolone mein antioxidative aur anty-inflammatory gatividhiyaan aur mitochondrial bioenergetics mein sudhaar karane kii kshamata hoti haye. omveloxolone vibhinn sanketon key liye naidaanik jaanch key tahat haye, jisamen friedrich kaa attaxia, mitochondrial myopathy, immunocology aur motiyabind kii sergery key baad corneal endothelial koshika key nuksan kii roktham shamil haye.
omveloxolone kii prabhavkarita aur suraksha kaa mulyankan 48-saptah key yaadrichhik, placebo-niyantrit, aur double-blind adhyayan [adhyayan 1 (aine. see. tii. 0255435)] aur ack open-label vistaar mein kiya gayaa thaa. adhyayan 1 ney 103 vyaktiyon koo friedrich key attaxia key saath namankit kiya jinhen 48 saptah key liye placebo (52 vyakti) yaa omveloxolone 150 milligram (51 vyakti) praapt huaa. shodh pratibhagiyon mein seey 53 pratishat purush they, 97 pratishat gorey they, aur adhyayan pravishti mein ausat ayu 24 varsh thee. nau (18 pratishat) rogi 18 varsh seey cumm ayu key they. praathamik uddeshya 48vein saptah mein placebo kii tulanaa mein sanshodhit friedrich key attaxia rating scale (aim. aff. aeye. aiss.) score mein parivartan kaa mulyankan karna thaa. aim. aff. aeye. aar. ack naidaanik mulyankan haye joe roga kii pragati koo maapata haye, arthaat nigalana aur bolna (bulb), oopari anga samanvaya, nichale anga samanvaya, aur seedhi sthirata. omeveloxolone praapt karane vaale vyaktiyon ney placebo praapt karane vaale logon kii tulanaa mein aim. aff. aeye. aar. parr behtar pradarshan kiya.
yuu.aiss. khaadya aur aushadhi prashaasan (aff. dee. aeye.) ney omeveloxolone anath aushadhi, twarit maarg, prathamikta sameeksha aur durlabh baal roga padnaamon key liye aavedan pradaan kiya.
shodh.
friedrich kaa attaxia.
ack praarambhik naidaanik pareekshan mein mitochondrial kaary key biomarker key preran key saath-saath aine. aar. aff. 2 lakshya jeane kii khuraak-nirbhar preran prateet hotaa haye. samay aur khuraak parr nirbhar tantrika sambandhi sudhaar dekhe gaye. rogiyon key saath ack charan 1 2017 mein puuraa kiya gayaa thaa aur charan 2 trail key parinam jahaan octuber 2019 mein dikhaaya gayaa thaa.

