
strictocidine synthes

strictocidine synthes (ee. see. 4.3.3.2) kshaariya jaiv sanshleshan mein ack enzyme haye joe ack aupchaarik chitra-spengler pratikriya mein strictocidine banaane key liye secologanin key saath tryptamine key sanghanan koo utprerit kartaa haih
choonki tryptamine aur secologanin kaa sanghanan kshaariya sanshleshan mein pahala pratibaddh kadam haye, isaliye sterecosidine synthes indol-alcaloid maargon key adhikansh key liye ack maulik bhoomika nibhaata haye.
yeh enzyme lices key parivaar seey sambandhit haye, vishesh roop seey amine lices, joe carbon-nitrogen bandhan koo todate hain. ise aposynacy parivaar (ee.) seey kaee kshaariya-utpaadak paudhon seey alag kiya jaa sakata haye.jee. "catharenthus rosus", "voekanga africana"). iss enzyme varg kaa vyavasthit naam 3-α ("s")-strictocidine tryptamine-lies (secologanin-forming) haye. aam upayog mein anya naamon mein strictocidine synthetase, aiss. aar., aur 3-α ("aiss")-strictocidine tryptamine-lies shamil hain. mool roop seey bhaaratiya lock chikitsa mein vyaapak roop seey upayog kiye jaane vaale ack aushadhiya paudhe "ravolfia sarpentina" seey alag, yeh enzyme terpanoid jaiv sanshleshan aur indol aur epicac kshaariya jaiv sanshleshan mein bhaag letaa haye, joe donon mahatvapurna shaaririk aur aushadhiya gunon vaale kaee yaugikon kaa utpaadan karate hain.
utpreran kaa tantra.
ravolfia sarpentina" seey strictocidine synthes key sanrachanaatmak adhyayanon key anusaar, tryptamine jeb key neeche sthit haye, jahaan glue 309 substrate key praathamik amine samooh key saath ack hydrogen bandhan banaata haye. avashesh 226 aur tyre 151, joe tryptamine key indol ring key samanantar hotey hain, paaee-bonned interaction key madhyam seey ack sandwich sanrachana mein tryptamine koo thheek karke isake bandhan koo aur sthir karate hain.
substrate binding parr, secologanin kii sthiti pockett key pravesh dwaar parr sthit hoti haye, jahan sakaratmak roop seey aaveshit avashesh usake 307 aur usake 277 secologanin key glucose bhaag key saath baandhate hain. secologanin key aldehyde-samooh aur tryptamine key amine samooh key beach ack shiff aadhar banata haye, jisase glue309 tryptamine key carbon 2 koo deprotonate kartaa haye. yeh electrophilic pratisthaapan key madhyam seey baad key ring bund key tahat sakht sideen key gathan kii anumati detaa haye, jaisa kii nikatvarti chhavi mein dikhaaya gayaa haye. 
strictocidine synthes tryptamine, secologanin aur acid utprerak kii sthaaniya sandrata koo badhaane key liye ack machaan key roop mein kaary karke 3-α ("s")-strictocidine gathan kii suvidha pradaan kartaa haye. isaki bandhan jeb bhee chakravaat key dauran iminium madhyavarti koo thheek seey disha detee haye taaki aapada-chayanaatmak roop seey isake kshaariya utpaadon kaa utpaadan kiya jaa sakey. kaee sachitra-spengler yaugikon key gathan key peechhe key tantra key vipareet, ack paanch-sadasyiya valay yukt ack spiroindolenin madhyavarti sakht-sideen sanshleshan key dauran naheen banata haye. saiddhaantik gananaon ney sanket diyaa kii iminium seey chhah-sadasyiya valay mein ack pratyaksh antar-roopaantaran spiroindolenin kii tulanaa mein kaee kramon mein adhik teji seey hotaa haye.
enzyme sanrachana.
strictocidine synthes kii samagr sanrachana mein ack 6-blade vaalaa β propeller fold hotaa haye joe chhah gunaa chhadm-samamiti aksh mein vyavasthit hotaa haye, jisamen pratyek propeller blade mein chaar-β strand hotey hain joe ack mudey hue, virodhi samanantar β-sheet banaate hain. teen helix bhee enzyme sanrachana key bheetar maujood hotey hain, jisamen propeller key sheersh parr hydrophobic binding pockett koo aakar dene vaale 3-helix hotey hain aur sakriya site key liye ack topi banaate hain. sakriya sthal banaane vaale mukhya amino acid avashesh hain tyre 105, trp 149, vail 167, mett 180, vail 208, ph 226, sair 269, mett 276, unakaa 277, unakaa 307, ph 308, glue 309, lyu 323 aur ph 324.
2007 key anta taka, iss varg key enzymon key liye 4 sanrachanaon koo hull kiya gayaa haye, jisamen pee. dee. bee. abhigam code, aur.
javic kaary.
 jaisa kii parichay mein kahaa gayaa haye, strictocidine synthes tryptamine aur secologanin kii javic chitra-spengler pratikriya koo 3-alfa (aiss)-strictocidine key roop mein utprerit kartaa haye, joe monoterpanoid indol alkaloid yaugikon key liye saarvbhaumik agradoot haye. yeh 7-ezaa-tryptamine key saath secologanin key yugman seey 12-ezaa-strictocidine key gathan koo bhee utprerit kartaa haye, joe cytotoxic alkaloids key liye ack mahatvapurna madhyavarti haye. enzyme koo ack ekal-prati jeane dwara kootbaddh kiya jaataa haye, joe praathamik aur maadhyamik paadap chayapachaya koo niyantrit karane mein shamil paadap harmon seey samanvaya viniyaman key adheen haye. koshika vibhajan mein ack aavashyak pravartak auxin dwara encoding jeane koo teji seey down-regulate kiya jaataa haye, jisase kshaariya sanchay key nimn star kii or jaataa haye. isake vipareet, jeane koo jasmonate dwara viniyamit kiya jaataa haye, joe ack paadap tanaav harmon haye, joe kii ack 42 aadhar-jodee kshetra key sakriyan key madhyam seey haye. catharenthus rosus" strictocidine synthes key kaee adhyayanon seey sanket milata haye kii enzyme kshaariya jaiv sanshleshan kii uchch darr koo banaae rakhane mein niyaamak bhoomika nibhaata haye. haalaanki, enzyme kii uchch gatividhiyaan apane aap mein kshaariya utpaadan koo badhaane key liye paryaapt naheen hain. ishtatam gatividhi praapt karane key liye strictocidine synthes key liye kissy atirikt coffector kii aavashyakta naheen haye, halanki "aposynacy" paudhon seey praapt enzyme key praarambhik adhyayanon ney "pee"-chloromercuribenzoate koo ack shaktishali avarodhak key roop mein pahachaana haye.
roga kii prasangikta.
 sakht synthes-utprerit sanghanan seey baney kaee indol alcaloid aushadhiya roop seey mahatvapurna yaugikon jaise kii quinin, antinoplastic dawa camptothesin, aur cancer rodhi davaaen winchristine aur winblastin key liye mahatvapurna agradoot hain. isake kaaran, sterecosidine synthes koo vyaapak roop seey chemoenzymatic alkaloid sanshleshan kii jaanch key liye pasand key enzyme key roop mein jaanaa jaataa haye. aisee hii ack jaanch mein paaya gayaa (21s)-12-ezaa-nesicline, ack 12-ezaa-strictocidine vyutpann, aeye549 cancer koshika rekha key liye shaktishali cytotoxicity pradarshit karane key liye. haalaanki, enzyme mein uchch star kii substrate vishishtata hoti haye, jisamen substrate pehchaan key liye aavashyak tryptamine kaa indol bhaag hotaa haye. haalaanki, haal key utparivarti adhyayanon ney sujhaav diyaa haye kii substrate vishishtata kii ack vyaapak shrinkhala key liye strictocidine synthes koo aasaani seey herfer kiya jaa sakata haye. udaaharan key liye, valeen-208 kaa elenin mein utparivartan chirality koo banaae rakhate hue apane tryptamine analogue seey 5-methyl aur 5-methoxystrictosidone utpann karane key liye strictocidine synthes kii anumati detaa haye. isake alawa, 3-alfa (aiss)-strictocidine kii samaan stereoselectivity key saath vibhinn secologanin analogue key saath bandhan koo aspartate-177 key utparivartan key madhyam seey alanine mein praapt kiya jaa sakata haye, jisase aage kii dawa khoj jaanch key liye sambhaavit kshaariya yaugikon kii ack vistrit shrinkhala key sanshleshan kii anumati milati haye.

