homocerin dehydrogenase

enzymology mein, ack homocerin dehydrogenase () ack enzyme haye joe rasayanik pratikriya koo utprerit kartaa haye.
iss enzyme key 2 substrate ell-homocerin aur nad + (yaa nadp +) hain, jabaki isake 3 utpaad ell-aspartate 4-semialdehyde, nad (yaa nadf), aur aich + hain.
yeh enzyme oxidoriductase key parivaar seey sambandhit haye, vishesh roop seey way joe sweekaarak key roop mein nad + yaa nadp + key saath daataa key chaa-oh samooh parr kaary karate hain. iss enzyme varg kaa vyavasthit naam ell-homoserinah nad (pee) + oxidoriductase haye. aam upayog mein anya naamon mein hsdh, aur hsd shamil hain.
homocerin dehydrogenase aspartate maarg mein teesare charan koo utprerit kartaa haye; homocerin mein aspartate beeta-semialdehyde kii nad (pee)-nirbhar kamee. homocerin threonin, isolacin aur methionine key jaiv sanshleshan mein ack madhyavarti haye.
enzyme sanrachana.
enzyme ack monofunctional roop mein, kuchh bacteria aur khameer mein paaya jaa sakata haye. khameer monofunctional enzyme kaa sanrachanaatmak vishleshan ingit kartaa haye kii enzyme teen alag-alag kshetron seey banaa ack diamer haye; ack aine-terminal nucleotide-binding domen, ack chhota kendriya dimerisation kshetra, aur ack see-terminal utprerak domen. aine-terminal domen ack sanshodhit roseman fold banaata haye, jabaki utprerak domen ack upanyaas alfa-beeta mishrit sheet banaata haye.
enzyme ack dwi-karyatmak roop mein bhee paaya jaa sakata haye jisamen ack aine-terminal aspartokinez domen aur ack see-terminal homocerin dehydrogenase domen hotaa haye, jaisa kii "escarichia kolai" jaise bacteria aur paudhon mein paaya jaataa haye.
dwi-karyatmak aspartokinez-homocerin dehydrogenase (aeye. key.-aich. aiss. dee.) enzyme mein ack niyaamak kshetra hotaa haye jisamen ack samanya loop-alfa-helix-loop-beeta strand loop-beeta strand motif key saath dou upa-domen hotey hain. pratyek upa-domen mein ack adhiniyam kshetra hotaa haye joe kaee alag-alag protein karyon key jatil viniyaman kii anumati detaa haye. aspartate kinnez key liye aeye. key.-aich. aiss. dee. jeane code, ack madhyavarti kshetra (dwi-karyatmak roop mein dou enzymon key beach linker kshetra key liye coding), aur anta mein homocerin dehydrogenase key liye coding anukram.
2007 key anta taka, iss varg key enzymon key liye 4 sanrachanaon koo hull kiya gayaa haye, jisamen pee. dee. bee. abhigam code, aur.
enzyme tantra.
homocerin dehydrogenase homocerin key liye aspartate-semialdehyde (aeye. aiss. aeye.) kii pratikriya koo utprerit kartaa haye. samagr pratikriya aspartate-semialdehyde carboxylic acid karyatmak samooh koo praathamik alcohol mein cumm curr detee haye aur aur aldehyde koo carboxylic acid mein aukseekrit curr detee haye. avashesh glue 208 aur lies 117 koo enzyme key sakriya utprerak sthal mein shamil maanaa jaataa haye. utprerit pratikriya mein hydride hastaantaran key liye aeye. aiss. pee. 214 aur ell. aaee. aiss. 223 koo mahatvapurna dikhaaya gayaa haye.
ack baar jaba aspartate-semialdehyde carboxylic acid koo ack aldehyde mein cumm curr diyaa jaataa haye aur aur aldehyde koo ack carboxylic acid mein aukseekrit curr diyaa jaataa haye, tou prayogon seey pataa chalata haye kii aiss. pee. 219, glue 208 aur ack paani kaa anu sakriya sthal mein aasaa koo baandhata haye jabaki ell. aaee. aiss. 223 ack proton koo aspartate-semialdehyde aspartate-semialdehyde oxygen mein daan kartaa haye. homocerin dehydrogenase mein ack nad (pee) aich coffector hotaa haye, joe phir usee carbon koo hydrogen daan kartaa haye, jisase aldehyde koo prabhaavi roop seey ack alcohol mein cumm curr detaa haye. (aankade 1 aur 2 kaa sandarbh lein).
haalaanki, poorna homocerin dehydrogenase utpreran kaa sateek tantra agyaat haye.
homocerin dehydrogenase-utprerit pratikriya koo ack dwi-dwi gati tantra key madhyam seey aage badhane key liye abhinirdhaarit kiya gayaa haye, jahaan nad (pee) aich coffector pahale enzyme koo baandhata haye aur pratikriya poori honey key baad enzyme seey alag honey vaalaa antim hotaa haye. isake alawa, jaba kii naad aur nadaf donon pratikriya key liye paryaapt saha-kaarak hain, naad koo prathamikta dee jaati haye. abhikriya kaa kimmy, naad key saath chaar gunaa chhota hotaa haye aur kcat/km teen gunaa adhik hotaa haye, joe ack adhik kushal pratikriya kaa sanket detaa haye.
homocerin dehydrogenase bhee substrate key upa-santript staron parr bahu-crum gativigyaan pradarshit kartaa haye. isake alawa, homocerin dehydrogenase key liye parivartaniya gativigyaan saha-kaarak prithakkaran kii tulanaa mein enzyme parisar seey amino acid substrate key teji seey prithakkaran kii ack kalaakriti haye.
javic kaary.
aspartate chayapachaya maarg asperagin key bhandaran aur aspartate-parivaar emino acid key sanshleshan donon mein shamil haye. homocerin dehydrogenase iss nitrogen aur carbon bhandaran aur upayog maarg mein ack madhyavarti charan koo utprerit kartaa haye. (chitra 3 kaa sandarbh lein).
prakaash sanshleshit jeevon mein, glutamine, glutamate aur aspartate dinn key dauran jamaa hotey hain aur anya amino acid koo sanshleshit karane key liye upayog kiye jaate hain. raat mein, aspartate koo bhandaran key liye asperagin mein parivartit kiya jaataa haye. isake alawa, aspartate kinnez-homocerin dehydrogenase jeane mukhya roop seey sakriya roop seey badhate hue, yuva paudhe key ootakon mein, vishesh roop seey epical aur paarshv maristem mein vyakt kiya jaataa haye.
standhaariyon mein samvarti chayapachaya maarg mein shamil enzymon kii kamee hoti haye, jisamen homocerin dehydrogenase bhee shamil haye. iss maarg mein lycine, threonin, methionine aur isolacin banaae jaate hain, isaliye unhein standhaariyon key liye aavashyak amino acid maanaa jaataa haye.
javic viniyaman.
homocerin dehydrogenase aur aspartate kinage donon mahatvapurna viniyaman key adheen hain (chitra 3 kaa sandarbh lein). aich. aiss. dee. koo aspartate chayapachaya maarg key downstream utpaadon dwara baadhit kiya jaataa haye, mukhya roop seey threonin. threonin aich. aiss. dee. aur aspartate kinnez donon key liye ack pratispardhi avarodhak key roop mein kaary kartaa haye. aeye. key.-aich. aiss. dee. mein vyakt karane vaale jeevon mein, threonin bandhan sthalon mein seey ack aeye. key. aur aich. aiss. dee. key beach key linker kshetra mein paaya jaataa haye, joe donon enzymon key sambhaavit allosteric avrodh kaa sujhaav detaa haye.
haalaanki, kuchh threonin-pratirodhi hsd roop maujood hain jinamen nishedh key liye shaaririk roop seey maujood threonin kii sandrata kii tulanaa mein bahut adhik aavashyakta hoti haye. aich. aiss. dee. key inn threonin-asamvedansheel roopon kaa upayog aanuvanshik roop seey engineer paudhon mein uchch poshan moolya key liye threonin aur methionine donon utpaadan koo badhaane key liye kiya jaataa haye.
homocerin dehydrogenase bhee pratilekhan viniyaman key adheen haye. isake pravartak anukram mein ack sis-niyaamak tatva teagact sequence hotaa haye, joe anya amino acid jaiv sanshleshit maargon mein shamil honey key liye jaanaa jaataa haye. apaardarshi 2 niyaamak tatva koo homocerin dehydrogenase viniyaman mein bhee shamil kiya gayaa haye, lekin isake prabhaav abhee bhee achchi tarah seey paribhaashit naheen hain.
paudhon mein, aeye. key.-aich. aiss. dee. jeane abhivyakti kaa paryavaraniya viniyaman bhee haye. prakaash key sampark mein aaney seey aeye. key.-aich. aiss. dee. jeane kii abhivyakti mein vriddhi hui haye, joe sambhavatah prakaash sanshleshan seey sambandhit haye.
roga kii prasangikta.
manushyon mein, rogjanak kavak seey honey vaali bimari mein mahatvapurna vriddhi hui haye, isaliye kavak-rodhi davaaon kaa vikas ack mahatvapurna jaiv rasayanik kaary haye. homocerin dehydrogenase mukhya roop seey paudhon, bacteria aur khameer mein paaya jaataa haye, lekin standhaariyon mein naheen, yeh antifungal dawa key vikas key liye ack majboot lakshya haye. haal hii mein, 5-hydroxy-4-oxnorvaline (hohn) koo hsd gatividhi koo aparivartaniya roop seey lakshit karane aur rokane key liye khoja gayaa thaa. hohn sanrachanaatmak roop seey aspartate semialdehyde key samaan haye, isaliye yeh abhinirdhaarit haye kii yeh hsd key liye ack pratispardhi avarodhak key roop mein kaary kartaa haye. isi tarah, (oun) 2-emino-4-auxo-5-hydroxypantanic acid (aar. aaee.-331), ack anya emino acid analogue, koo bhee aich. aiss. dee. koo rokane key liye dikhaaya gayaa haye. yeye donon yaugik "cryptococcus neophormans" aur "cladosporium phulwoom" key khilaf prabhaavi hain.
amino acid analogue key alawa, kaee phenolic yaugikon koo hsd gatividhi koo rokane key liye dikhaaya gayaa haye. hohn aur aar. aaee.-331 kii tarah, yeye anu pratispardhi avarodhak hain joe enzyme sakriya sthal seey judate hain. vishesh roop seey, phenolic hydroxyl samooh amino acid binding site key saath baatchit kartaa haye.

