
cialoblastoma

sialblastoma ack nimn-shreni laar granthi neoplasm haye joe adim laar granthi enlays koo punah praapt kartaa haye. ise pahale "janmajaat besal cell adenoma", "bhroon" yaa "baseloid adenocarcinoma" key roop mein sandarbhit kiya gayaa haye.
yeh ack behad durlabh tumour haye, jisamen duniya bhar mein 100 seey cumm mamle saamane aae hain.
sanket aur lakshan.
adhikansh tumour kii pehchaan paroted laar granthi mein kii jaati haye, halanki upa-mandibular granthi bhee prabhaavit hoe sakati haye. lakshan gair-vishisht hotey hain, lekin isamen dravyamaan, aksar teji seey failna, yaa dravyamaan key oopar twacha kaa vran shamil hotaa haye. bahut durlabh udaharanon mein, anya tumours key saath sambandh, jaise kii nevas sebasius aur hepatoblastoma kaa dastavejikaran kiya jaataa haye. ultrasound kaa upayog dravyamaan kii jaanch key liye kiya jaa sakata haye, ack takneek jise prenately bhee kiya jaa sakata haye. aim. aar. aaee. kaa bhee upayog kiya jaa sakata haye, lekin nishkarsh gair-vishisht hain.
pathology nishkarsh.
tumour multinodular yaa lobular hotey hain, joe kabhi-kabhi necrosis yaa raktasraav key kshetron koo darshaate hain. inca aakar 2 seey 7 semi taka hotaa haye. 
jaisa kii apekshit hoga, sookshmadarshi key tahat ootakiya visheshtaen lagbhag teesare maheene mein bhroon vikas mein dekhi jaane vaali visheshtaon key samaan hain. dou pramukh pratiroop hain. 
donon pattern mein baseloid koshikaaen hoti hain joe thhos ghonsale, gaanthon yaa trabacula mein vyavasthit hoti hain, jisamen fokal paridhiya polycedding hoti haye. naabhik goal seey andakar hotey hain aur najuk chromatin aur aamtaur parr ack ekal naabhik hotey hain. kabhi-kabhi nalikaaen dekhi jaa sakati hain. prishthabhoomi stroma dheela, aparipakva aur kabhi-kabhi mixoid hotaa haye. necrosis maujood hoe sakata haye. mitotic aakritiyaan aksar aasaani seey mill jaati hain.
tumour koshikaon kaa pareekshan immunohistochemistry dwara kiya jaa sakata haye joe darshaata haih
ductal koshikaaenh keratin, see. key. 7 aur see. key. 19 key saath sakaratmak.
baseloid yaa myopithalial koshikaaenh aiss 100 protein, maanspeshiyon key liye vishisht actin, calponin aur pee 63 key saath sakaratmak.
prasaar marker, kii-67, badhee hui labeling dikhaa sakata haye, aur jaba aisaa hotaa haye, tou yeh ack pratikool parinam seey judaa hotaa haye.
nidan.
yeh mahatvapurna haye kii upchaar shuru karane seey pahale anya tumour jaise pleomorphic adenoma, besal cell adenoma, adenoid cystic carcinoma aur terratoma koo baahar rakhaa jaae.
prabandhan.
upchaar mein poorna shalya chikitsa shamil haye. yadi tumour koo poori tarah seey naheen hataaya jaa sakata haye, tou chemotherapy parr vichaar kiya jaa sakata haye. haalaanki, chemotherapy key rogiyon key liye deerghakaalik pratikool parinam hoe sakate hain joe aamtaur parr bahut chhote hotey hain.
mahamari vigyaan.
adhikansh rogi dou saal seey cumm umr key hotey hain, jinamen seey adhikansh navjat avadhi key dauran pesh hotey hain. ladakon koo ladkiyon kii tulanaa mein thodaa adhik prabhaavit kiya jaataa haye (1.2:1).

