
koshika vibhajan mein calcium sanket

cellular vibhajan kii ghatnaaon koo niyantrit karane mein calcium ack mahatvapurna bhoomika nibhaata haye. calcium ack dwiteeyak sandeshvaahak key roop mein antahkoshikiya sanket koo sanshodhit karane aur vibhajan key madhyam seey koshikaon key pragati key roop mein sanrachanaatmak parivartanon koo suvidhajanak banaane key liye donon kaary kartaa haye. antahkoshikiya calcium gatiki key utkrisht niyantran kii aavashyakta hoti haye, kyonki calcium kaee koshika chakr chaukiyon parr ack bhoomika nibhaata prateet hotaa haye.
pramukh downstream calcium prabhaavak calcium-binding callodulin protein aur downstream callodulin-nirbhar protein kinnesses i/ii hain. sakshya iss sanket cascade koo koshika vibhajan mein calcium sanket key ack pramukh madhyasth key roop mein ingit karate hain.
ardhasutran.
aitihaasik roop seey, antahkoshikiya calcium kii sabse achchi visheshtaon mein seey ack shukranu nishechan key baad andashay kaa sakriyan haye. deuterosome andey (standhaariyon, machhliyon, ubhaycharon, acidian, samudri archin aadi) mein.), shukranu key safal pravesh seey antahkoshikiya calcium ayanon (see. aeye. 2 +) mein ack vishisht vriddhi hoti haye, jisamen standhaariyon aur acidians ney ardhasutri vibhaajak key puuraa honey key liye aavashyak antahkoshikiya calcium spikes kii ack shrinkhala pradarshit kii haye... anupayogi kasheruki andey ardhasutran key baad vikas koo rokte hain. iss vikasatmak viram kaa shreya aspasht roop seey paribhaashit cytostatic kaarak (see. aiss. aff.) koo diyaa jaataa haye. vartamaan shodhon seey pataa chalata haye kii "see. aiss. aff." vaastav mein ardhasutri vibhaajak II mein vibhajan koo rokane key liye ack saath kaam karane vaale kaee maarg hain. andey mein shukranu key pravesh parr, see. aeye. 2 + koo antahkoshikiya bhandar seey chhoda jaataa haye, jisase see. aiss. aff.-arrest tantra kaa avrodh hotaa haye. callodulin aashrit kinnez II koo see. aeye. 2 + pravaah sanket koo see. aiss. aff. key avrodh mein parivartit karane aur cycline ksharan machinary koo sakriya karane key liye jimmedaar protein dikhaaya gayaa thaa, jisake parinamswarup ardhasutri vibhaajak key madhyam seey pragati hoti haye.
standhaariyon mein, see. aeye. 2 + mein yeh vriddhi shukranu dwara pradaan kiye gaye pee. ell. see. jey. ee. aiss. dwara prerit aaee. pee. 3 uttejana dwara sanchaalit dikhaai gaee thee. samanya taur parr, plc enzyme aantarik bhandaron dwara pp2 key aaee. pee. 3 aur dee. aeye. jee. mein tootane key madhyam seey calcium release koo uttejit karate hain.
mitosis.
sanket.
ardhasutri vibhaajanak ghatnaasan parey, see. aeye. 2 + starme parivartan vibhaajanak vibhinn charaname vibhinn jeevasabhame dekhal jaait achhi, jenaa paramanu jhilleek vichhed aaa metafage-anaphase sankraman. isake alawa, haal key kaam ney jee2 mein rookie hui koshikaon key shaman mein yaantrik roop seey prerit teji seey pravesh dikhaaya haye. aage, vibhajan key madhyam seey pragati key liye calcium (jee1/aiss, jee2/aim, aur metafage/anaphase) kii upasthiti kii aavashyakta hoti haye, joe sujhaav detaa haye kii jaanch binduon key liye calcium-nirbhar sanket tantra kii aavashyakta hoti haye.
jee1/एस।.
aiss-charan mein pravesh calcium parr nirbhar haye. aantarik calcium bhandaron mein kamee dna sanshleshan kii shuruat koo rokti haye. ack sambhaavit tantra yeh haye kii cycline ack sanshleshan koo baadhit kiya jaataa haye, joe see. dee. key. 2 gatividhi koo rokta haye joe dee. aine. aeye. sanshleshan kii shuruat key liye aavashyak haye.
jee2/aim.
koshika chakr kii pragati kaee maargon dwara niyantrit kii jaati haye. yeh maanav cancer koshika rekhaaon kaa upayog karke dikhaaya gayaa thaa kii jee2/aim jaanch chauki kaimki aur maipak crosstock dwara viniyamit haye. yahaan, kaimki meck/erk koo sakriya kartaa haye, joe pee27 protein koo pakadane vaale koshika chakr koo cumm kartaa haye.
roga.
samanya taur parr, parivartit koshikaaen calcium-swatantra tareeke seey failati hain, jabaki gair-parivartit koshikaaen atirikt-koshikiya calcium ekagrata key prati uchch samvedansheelta dikhaati hain, joe sujhaav detee hain kii oncogenic vikas mein calcium sanket kaa vyavadhaan shamil hoe sakata haye.
chromatin sanrachana.
chromatin kaa sanghanan koshika vibhajan mein ack mahatvapurna kadam haye, jisase koshikaaen dotter koshikaon mein gunasutron koo samaan roop seey vitarit curr sakati hain. haal key kaam ney sujhaav diyaa haye kii prometaphase mein chromatin sanghanan koo saksham karane key liye see. aeye. 2 + kii aavashyakta haye. samanya cytosolic calcium sandrata kii tulanaa mein calcium koo sanghanit dna parr bahut adhik star parr kendrit paaya gayaa. sanghanan mein calcium kii bhoomika kaimak function seey swatantra thee, joe chromatin sampeedan mein see. aeye. 2 + kii vishuddh roop seey sanrachanaatmak bhoomika kaa sujhaav detee haye. isake alawa, iss parinam koo nikaale gaye chromatin key saath "inn vitro" key roop mein pradarshit kiya gayaa, iss baat parr jore dete hue kii kewal see. aeye. 2 + kii upasthiti chromatin kii sanrachana koo prabhaavit curr sakati haye.

