
tmem131

transmembrane protein 131 (tii. aim. ee. aim. 131) ack protein haye jise manushyon mein "tii. aim. ee. aim. 131" jeane dwara kootbaddh kiya jaataa haye. tii. aim. ee. aim. 131 protein mein agyaat kaary 3651 (dee. yuu. aff. 3651) key teen kshetra aur dou transmembrane kshetra hotey hain. iss protein koo tii koshika kaary aur vikas mein bhoomika nibhaane key roop mein shamil kiya gayaa haye. "tmem131" ack locus (2q11.1) mein bhee rahata haye joe hataae jaane parr neavergelt syndrome seey judaa hotaa haye.
tii koshika kaary mein bhoomika.
"tii. aim. ee. aim. 131". koo down syndrome key rogiyon mein hypermethylation pradarshit karane key liye dikhaaya gayaa haye. iss adhyayan key lekhakon ney prastaav diyaa kii, tii koshika vikas aur kaary mein tmem131aiss key kathit kaary koo dekhate hue, yeh hypermethylation down syndrome key rogiyon mein dabaaye gaye pratiraksha kaary mein bhoomika nibha sakata haye.
tii koshikaon key vikas aur vibhedan key dauran tmem131 koo bhee viniyamit dikhaaya gayaa haye, aur anya ootak prakaron key saapeksh tii koshikaon mein abhivyakti kaa star apekshaakrit uchch dikhaaya gayaa haye.
jeane.
avalokan.
"tmem131" gunasutra 2 key nakaratmak dna strand (arth dekhein) parr 98,372,799-98,612,354 seey sthit haye. jeane utpaad maanav jeane mein 41 anumaanit exon key saath 6,657 aadhar jodee mrna haye. ensemble duss vaikalpik splies roopon kii bhavishyavani kartaa haye, jinamen seey chaar protein coding hain. 
promoter bhavishyavani aur vishleshan genomatics software pays key madhyam seey "ell dorado" kaa upayog karke kiya gayaa thaa. anumaanit pravartak kshetra gunasutra 2 key minus strand parr 98,611,892 seey 98,612,893 taka 1002 aadhar jode mein faila huaa haye. karyakram ney dou sambhaavit pratilekhan praarambh sthaanon kii bhavishyavani kii. pahala 98,612,501 seey 98,612,716 taka key 216 aadhar jode mein faila huaa haye. doosara 98,612,262 seey 98,612,443 taka key 182 aadhar jode mein faila huaa haye.
jeane pados.
"tmem131" sakaratmak dee. aine. aeye. strand parr "zap70" jeane (98,330,331-98,356,323) key seedhe buggle mein sthit haye, saath hii saath 2q11.2 locus parr kaee chhadmajan hain. ack wonn willebrand kaarak jisamen jeane (vee. doubleu. aeye. 3bee.) hotaa haye, sakaratmak strand (98,703,595-98,929,410) parr "tii. aim. ee. aim. 131" seey oopar kii or sthit hotaa haye.
jeane abhivyakti.
"tii. aim. ee. aim. 131". koo poore shareer mein nimn seey madhyam star mein vyakt kiya jaataa haye, jisamen lymph nodes, garbhashay aur tii koshikaon mein thodaa badhaa huaa star hotaa haye. phal makkhi bhroon key vikas mein abhivyakti detta bee. dee. jee. pee. "inn seetu" homepage seey upalabdh haye. 
protein.
guna/visheshataaen.
tii. aim. ee. aim. 131 protein kaa praathamik kaary achchi tarah seey samajha naheen gayaa haye. maanav roop mein 1883 emino acid avashesh hain, jinka summ-vidyut bindu 8.74 haye aur aanvik dravyamaan 205,100 dalton haye. yeh avasheshon 1,091-1,111 aur 1,118-1,138 parr dou transmembrane domen koo shamil karane key liye dikhaaya gayaa haye. teen duff3651 kshetra dou aasann transmembrane domen key aine-terminal paksh parr sthit hain. yeye avasheshon 173-245,502-582, aur 639-708 parr sthit hain. protein kaa antahkoshikiya sthaan prayogaatmak roop seey nirdhaarit naheen kiya gayaa haye, lekin yeh plasma jhilli yaa endoplasmic reticulum mein rahata haye, jisamen transmembrane kshetron key aine-terminal aur see-terminal donon taraf pratyek domen cytosolic hotaa haye. isamen kaee phosphorylation sthal hain jinhen prayogaatmak aur jaiv soochanaatmak upkaranon donon key saath dikhaaya gayaa haye. netphos" upkaran kaa upayog karke protein key jaiv-soochanaatmak vishleshan ney protein kii poori lambai mein 145 sambhaavit phosphorylation sthalon kii bhavishyavani kii.
protein antahkriya.
tii. aim. ee. aim. 131 key liye protein antahkriya vishleshan computational upkaranon kaa upayog karke kiya gayaa haye. taksal databases key madhyam seey koee antahkriya naheen pahachaani gaee. ack string khoj ney paath khanan key madhyam seey duss sambhaavit protein antahkriyaon kaa khulasa kiya, halanki inmein seey kissy koo bhee vaastavik protein-protein antahkriya naheen maanaa jaanaa chaahiye. parinamon kaa gahan vishleshan inn bhavishyavaniyon key vaastavik honey kii bahut cumm sambhavana dikhaata haye. akshunna upkaran kaa bhee upayog kiya gayaa thaa, aur isase pataa chalaa kii superoxide dismutage 2 (soad2) key saath ack sambhaavit antahkriya paaee gaee thee, jisaki pehchaan khameer dou-sankar jaanch adhyayan mein kii gaee thee.
sanrakshan.
orthologue.
tmem131 apane sabhi orthologue mein sanrakshit haye. puuraa protein primate orthologue mein atyadhik sanrakshit haye, jabaki sanrakshan adhik door key homolog mein duff3651 aur transmembrane kshetron key bheetar adhik haye.
orthologue prajaatiyon mein paae gaye joe manushyon seey door seey sambandhit they, jaise kii visfot kaa upayog karate hue chonoflagelate "monosiga bravicolis" aur saine diago super computer biology workbench key madhyam seey sanrekhit upkaran. nimnalikhit talika tmem131 key samroopataon key baare mein jaankaari detee haye.
paralog.
tmem131 kaa ack hii paralog haye, "tmem131ell" yaa "kiaa0922"।. yeh jeane tmem131 key samaan haye, lekin isamen teen duf3651 kshetron mein seey dusare dou shamil naheen hain.