
cyclothiazomycin

cyclothiazomycin praakritik utpaadon kaa ack samooh haye, jise theopeptides key roop mein vargeekrit kiya gayaa haye, joe bacteria kii vibhinn "streptomyces" prajaatiyon dwara utpaadit hotey hain.
yeye yaugik ribosomaly sanshleshit aur post-translational roop seey sanshodhit peptides (rips) hain aur inhen aage theopeptides key roop mein vargeekrit kiya jaa sakata haye. cyclothiazomycin kii samagr sanrachana mein ack macrocyclic cyclic peptide shamil haye jisamen kaee thiazol aur thiazolin hotey hain. cyclothiazomycin mein raktchaap koo cumm karane seey laker aar. aine. aeye. pratilekhan mein hastakshep karane taka kaee avarodhak prabhaav honey kii soochana haye; way kuchh antibiotic gatividhi bhee pradarshit karate hain.
itihas.
belothiazomycin aeye koo pahale "streptomyces" sp seey alag kiya gayaa thaa. 1991 mein aine. aar. 0516. cyclothiazomycin aeye kii sanrachana koo aine. aim. aar. spectroscopy aur rasayanik ksharan key madhyam seey hull kiya gayaa thaa. isase pahale, ack peptide yaugik 5102-iii koo 1982 mein "streptomyces hygroscopicus" 10-22 seey alag kiya gayaa thaa. 2010 mein cyclothiazomycin key jaiv sanshleshan key liye jimmedaar jeane kii khoj seey pataa chalaa kii 5102-iii aur cyclothiazomycin a ack hii yaugik they.
sanrachanaatmak anuroop cyclothiazomycin bee1 aur bee2 koo "streptomyces" sp seey alag kiya gayaa thaa. aeye307 aur 2006 mein uchch-resolution dravyamaan spectrometry aur nmr spectroscopy kii madad seey hull kiya gayaa.
ack teesara analogue, cyclothiazomycin see, 2014 mein genome khanan, nucleophilic 1,4-edition labeling pratikriyaon, uchch resolution maas spectrometry aur nmr spectroscopy kii sahaayata seey khoja gayaa thaa.
sanrachana.
cyclothiazomycin thiazol yukt cyclic aur macrocyclic peptides hain joe sanrachanaatmak roop seey theostrepton aur noshiheptide key samaan hain. ribosomaly sanshleshit aur post-translational roop seey sanshodhit peptides (rips) key badey parivaar key bheetar aupchaarik roop seey theopeptides key roop mein vargeekrit, cyclothiazomycin koo shuru mein peptides key roop mein jaiv sanshleshan kiya jaataa haye, joe baad mein rasayanik sanshodhanon seey gujarate hain, jisamen macrocyclisation, sugandh, cyclodehydation aur nirjalikaran shamil hain. cyclothiazomycin teen anuroop key roop mein maujood hain joe core peptide mein dou emino acid avasheshon parr bhinn hotey hain. neeche dee gaee chhavi laal rung mein analogue key saath-saath amino acid anukram key beach key antar koo darshaati haye joe antim yaugik bunn jaataa haye.
cyclothiazomycin aeye kii sanrachana mukhya roop seey dou-ayami paramanu chumbakiya anunaad spectroscopy dwara sthaapit kii gaee thee. cyclothiazomycin aeye mein ack dihydroelnin aur dou dehydrohomalanine avashesh hotey hain joe ack cyclic, macrocyclic machaan key bheetar thyzoline, thiazol aur ack trisubilituted pyridine seey baney hotey hain.
cyclothiazomycin bee aur see agradoot peptide key mool anukram mein dusare aur teesare threonin avasheshon mein cyclothiazomycin aeye seey bhinn hotey hain. cyclothiazomycin bee mein, doosara thronin ack arginine haye. cyclothiazomycin bee diasteriomers, cyclothiazomycin bee1 aur cyclothiazomycin bee2 kii ack jodee key roop mein maujood haye, joe isake ack nirjaleekrit-alanine moities key vinyas mein bhinn hotey hain. cyclothiazomycin bee1 aur bee2 vilayan mein samarupikaran dwara parivartit hotey hain lekin thhos avastha mein sthir hotey hain.
cyclothiazomycin see mein cyclothiazomycin aeye mein paae jaane vaale dusare threonin avashesh key sthaan parr ack lycine hotaa haye aur teesare threonin avashesh key sthaan parr ack serin avashesh hotaa haye, jisake parinamswarup cyclothiazomycin aeye mein dekhe jaane vaale dehydrohomalanine key bajaay ack dehydroalanine hotaa haye.
jaiv sanshleshan.
cyclothiazomycin praakritik utpaadon key ack varg kaa hissa haye joe ribosomaly sanshleshit aur post-translational roop seey sanshodhit peptides (rips) hain. iss tarah, cyclothiazomycin ack peptide key roop mein shuru hotaa haye joe bacterial ribosome mein sanshleshit hotaa haye. jaiv sanshleshit enzymon dwara rasayanik charanon kii ack shrinkhala mool peptide koo antim (paripakva) praakritik utpaad mein badal detee haye.
cyclothiazomycin key liye jeane encoding ack chhote khule padhane key frame (oh. aar. aff.) "see. tii. aim. aeye." ("clta") key saath shuru hoti haye. "see. tii. aim. dee." ("" see. ell. tii. bee. "") ack "" fused "" tomm cyclodehydrates koo kootbaddh kartaa haye joe maanaa jaataa haye kii thiazolin key gathan mein bhaag letaa haye.  maanaa jaataa haye kii "see. tii. aim. bee". ("see. ell. tii. see".) jeane dwara kootbaddh enzyme thiazolin key thiazol mein nirjalikaran koo utprerit kartaa haye. "ctme" aur "ctmf" ("ctl" aur "see. ell. tii. aff") pratyek ack vibhajit lanthipeptide nirjalikaran koo kootbaddh karate hain joe serin aur threonin koo nirjalikaran seey nirjalikaran aur nirjalikaran mein parivartit kartaa haye. "see. tii. aim. jee" ("see. ell. tii. jee") koo kendriya pyridine key utpaadan mein sahaayata karane key liye maanaa jaataa haye. "ctmi" ("clad") ack thiff jaise protein koo kootbaddh kartaa haye. "see. tii. aim. aich" ("see. ell. tii. aich") ack laksar-prakaar kaa niyaamak jeane haye. "see. tii. aim. jey. key" cycloethiazomycin aeye aur see samoohon mein maujood naheen hain; koee gyaat kaary naheen haye. see. ell. tii. aine.". jeane koo ack enzyme koo kootbaddh karane key liye maanaa jaataa haye joe tritiyak theoither key gathan mein shamil haye, haalaanki yeh saabit naheen huaa haye aur "see. ell. tii. aine.". dwara viniyamit naheen haye."see. tii. aim. aeye.", "see. tii. aim. dee.", "see. tii. aim. aff.", aur "see. tii. aim. jee." hataane seey cyclothiazomycin aeye. gayab hoe jaataa haye.
"see. tii. aim. aich. ack laksar-prakaar kaa niyaamak jeane haye jise" "see. tii. aim. aeye" "-" "see. tii. aim. ell" "koo viniyamit karane key liye dikhaaya gayaa thaa.
jaiv sakriyata.
maanaa jaataa haye kii cyclothiazomycin kaa pratyek analogue cumm seey cumm ack javic lakshya key saath baatchit kartaa haye. cyclothiazomycin aeye koo rakt plasma renin koo rokane key liye dikhaaya gayaa haye jisase raktchaap mein kamee aatee haye; yeh kamjor anty-fangal gatividhi bhee pradarshit kartaa haye. cyclothiazomycin bee aar. aine. aeye. polymerase key khilaf avarodhak gatividhi dikhaata haye, aur maanaa jaataa haye kii yeh ribosome parr nirbhar jee. tii. pee. aiz koo cumm karke kaary kartaa haye. cyclothiazomycin bee koshika divaaron key chittin seey judkar anty-fangal gatividhi bhee pradarshit kartaa haye, iss prakaar ack najuk koshika deewaar kaa utpaadan kartaa haye. haal hii mein khoja gayaa cyclothiazomycin see kii ack agyaat javic bhoomika haye, lekin cyclothiazomycin bee aur see donon graam-positive bacteria key khilaf jivanurodhi gatividhi pradarshit karate hain, jisamen "basilus anthrasis" shamil haye.

