
sime-simr toxin-antitoxin pranali

sime-simmer toxin-antitoxin pranali mein ack chhota sahajeevi endonucles toxin, sime aur ack gair-coding aar. aine. aeye. sahajeevi aar. aine. aeye. antitoxin, simmer hotaa haye, joe sime anuvaad koo rokta haye. sime-simmer ack prakaar kaa aaee toxin-antitoxin pranali haye, aur antitoxin, simmer dwara viniyamit haye. maanaa jaataa haye kii sima-simr parisar kshatigrast aar. aine. aeye. aur dee. aine. aeye. key punarchakran mein mahatvapurna bhoomika nibhaata haye. sime aur simr key sambandh aur sambandhit sanrachanaaen vishaaktata key tantra aur procariotic pranaliyon mein samagr bhoomika mein antardrishti pradaan karati hain.
khoj.
simmer koo mool roop seey aar. aaee. jey. see. label kiya gayaa thaa aur yeh ack 77 nucleotide (aine. tii.) aar. aine. aeye. haye jisamen ack σ70 pravartak haye. aar. aaee. jey. see. koo vipareet strand parr "vaaee. jee. doubleu". khule padhane key frame koo 6 aine. tii. seey overlap karate hue paaya gayaa thaa, aur ise ack anticence aar. aine. aeye. key roop mein chihnit kiya gayaa thaa joe "vaaee. jee. doubleu". key 5 'anuvaadit kshetra koo baandhata haye. aage key adhyayan ney kramshah "yjw" aur ryjc donon kaa naam badalkar syme (bhulbhulaiya key saath samaantaa key saath sos-prerit yjw jeane) aur symr curr diyaa. aeye. bee. aar. bee. super family key saath samaantaon key bavjood, sime parivaar vishesh roop seey proteobacteria mein paaya gayaa haye. 
sime aur simmer key beach sambandh.
simr anticence aar. aine. aeye. koo simm start coden key peechhe 3 aine. tii. likhaa jaataa haye, yahee kaaran haye kii simr pravartak koo simm coden key bheetar antarnihit maanaa jaataa haye. natijatan, simmer anticence binding dwara sime key aar. aine. aeye. anuvaad koo avaruddh kartaa haye, yeh sujhaav dete hue kii yeh antatah simmer mrinaa ksharan kii or leey jaataa haye. amino acid vishleshan ney nishkarsh nikala haye kii sime ack aar. aine. aeye. cleavage protein mein vikasit hoe sakata haye joe pratilekhan karakon yaa antitoxin key kaaran vish jaise vyavhaar koo pradarshit kartaa haye. anya samanya vish-antitoxin pranaliyon key vipareet, simr antitoxin, sime toxin kii tulanaa mein adhik sthir haye. 
dee. aine. aeye. kshati key baad, aiss. oh. aiss. pratikriya simr aar. aine. aeye. key pratilekhan koo dabaati haye, jisase dee. aine. aeye. kii marammat honey taka sima toxin sambhaavit roop seey kshatigrast aim. aar. aine. aeye. koo cumm curr sakata haye. isake vipareet, lexa repressor binding site, simr aur lone protease dwara sime koo kaskar dabaaya jaataa haye. yeye teen kaarak kaee staron parr maujood hain jahan lexa pratilekhan downeragulation mein shamil haye, simr rna anuvaad downeragulation mein shamil haye, aur lone protease protein ksharan mein shamil haye. sime parr daman kii seema lexa, simmer aur lone protease kii yogaatmak shakti parr nirbhar karati haye. kull milakar, sime sanshleshan dheema haye kyonki isaki gatividhi dee. aine. aeye. marammat protein parr atyadhik nirbhar haye. cellular vatavaran mein, mitomycin see dna koo nuksan pahunchaata haye joe dna kii marammat shuru karane key liye sima marna key atee-abhivyakti kii or leey jaataa haye.
vishaaktata.
inn vitro" pareekshan key dauran, roganu kii atee-abhivyakti ney coloney banaane vaali koshikaon key vikas parr nakaratmak prabhaav kaa pradarshan kiya. koshika key bheetar vaishvik anuvaad koo dabaakar, ack anya vishaakt padaarth maazaf key samaan tareeke seey marna koo alag karke, sime apani vishaaktata pradarshit kartaa haye. matratmak uttari blott prayogon seey pataa chalaa kii simmer aar. aine. aeye. koshikaon mein sime aim. aar. aine. aeye. (0.02 aff. aim. oh. ell.-1 aur 0.2 aff. aim. oh. ell.-1) kii sandrata key 10 gunaa parr maujood haye. 
sanrachana.
sime.
sime toxin mein 113 emino acid hotey hain. amino acid anukram aur sime kii tritiyak sanrachana kaa mulyankan karate samay, majboot samaantaaen paaee gaeen joe aeye. bee. aar. bee. superfamly seey milati-julati theen. yeh superfamily mukhya roop seey pratilekhan karakon yaa antitoxin key roop mein kaary kartaa haye; haalaanki, aeye. bee. aar. bee. superfamily key praathamik anukram aur tritiyak sanrachana key liye sime kii samaantaa seey pataa chalata haye kii sime protein ney ack pratilekhan kaarak yaa antitoxin seey ack aar. aine. aeye.-sambaddh protein mein vikaasvaadi badalaav kaa anubhav kiya joe vishaakt vyavhaar koo pradarshit kartaa haye. aeye. bee. aar. bee. superfamily protein sanrachana aur sime protein sanrachana key beach, kaee pramukh hydrophobic avashesh hain joe protein key kendra mein sootra 1-helix key saath-saath sootra 2 strand-1 mein atyadhik sanrakshit hain. inn pramukh samaantaon key bavjood, sime dhruviya avasheshon koo pradarshit kartaa haye joe aeye. bee. aar. bee. superfamly kii samanya sanrachana mein naheen paae jaate hain, joe darshaata haye kii inn avasheshon kii sime aar. aine. aeye. cleavage kshamata mein bhoomika hoe sakati haye.
swiss-model mein kaee prayogaatmak sanrachanaaen aur saiddhaantik samroopata model hain joe crum praathamik anukram aur tritiyak sanrachana key kuchh pahaluon koo paribhaashit karate hain. uniprotcub abhigam sankhya pee39394 mein syremic vish kii samanya sanrachana koo ingit kartaa haye. swiss-model pranali saiddhaantik model mein, sootra _ 1-helix mein amino acid g44, q45, w46, l47, e48, a49 aur a50 hotey hain. sootra _ 2 strand-1 mein amino acid g55, t56, a57, v58, d59, v60, k61, v62, i67, v68, l69, t70, a71, q72, p73 aur p74 hotey hain, jisamen sootra _ 2-turn hotaa haye jisamen m63, e64, g65 aur c66 hotey hain.
simr.
simr ack anticence aar. aine. aeye. haye jiska arth haye kii isaki maadhyamik sanrachana mein vishisht stame-aind-loop tatvon key saath-saath sanrachana key buggle mein yugmit kshetra bhee hain. simr kii anumaanit maadhyamik sanrachana nucleotide anukram seacag vaale ack loop koo pradarshit karati haye. iss visheshta vaale loop koo ell. aiss. tii. aar.-1 aur oh. aich. aiss. see. aar. aine. aeye. protein key saath saajha kiya jaataa haye aur anya proteins key liye ack bandhan sthal honey kaa anuman lagaaya jaataa haye. vartamaan mein, aar. see. aiss. bee. protein detta baink yaa swiss-model repository parr koee gyaat faailen naheen hain joe simr kii anumaanit tritiyak sanrachana kaa sanket detee hain. 

