
dimethendrolone undecanoate

dimethendrolone undecanoate (dee. aim. aeye. yuu.), jise isake vikasatmak code naam see. dee. bee.-4521 seey bhee jaanaa jaataa haye, ack prayogaatmak aurrojan/anabolic steroid (aeye. aeye. aiss.) aur progestogen dawa haye joe purushon key liye ack sambhaavit janm niyantran goli key roop mein vikasit kii jaa rahee haye. yeh munh seey liya jaataa haye, lekin maanspeshiyon mein injection dwara bhee diyaa jaa sakata haye.
dee. aim. aeye. yuu. key dushprabhavon mein halka vajan badhana aur aich. dee. ell. collestroll key star mein halki kamee shamil haye. yeh astrogen key nimn star aur sambandhit lakshnon jaise kii cumm yaun kaary aur huddy key khanij ghanatva mein kamee kaa kaaran bhee bunn sakata haye. dee. aim. aeye. yuu. ack aas haye, aur isaliye androgen receptor kaa ack agonist haye, joe testosterone jaise androgen kaa javic lakshya haye. yeh ack progestine, yaa ack synthetic progestogen bhee haye, aur isaliye progesterone receptor kaa ack agonist haye, joe progesterone jaise progestogen kaa javic lakshya haye. apani androgenic aur progestogenic gatividhi key kaaran, dee. aim. aeye. yuu. mein antigonadotropic prabhaav hotey hain. inn prabhaavon key parinamswarup shukranu utpaadan kaa prativarti daman hotaa haye aur purushon mein dee. aim. aeye. yuu. key garbhanirodhak prabhaavon key liye jimmedaar hotey hain. dawa mein koee astrogenic gatividhi naheen hoti haye. dee. aim. aeye. yuu. dimethendrolone kii ack dawa haye.
dee. aim. aeye. yuu. kaa pahali baar 2002 mein varnan kiya gayaa thaa. ise sanyukt raajya sarkaar mein ack agency, rashtriya baal swaasthya aur maanav vikas sansthaan kii garbhanirodhak vikas shakha dwara vikasit kiya gayaa thaa.
chikitsa upayog.
dee. aim. aeye. yuu. ack prayogaatmak dawa haye aur vartamaan mein chikitsa upayog key liye anumodit naheen haye. yeh ack sambhaavit purush harmonal garbhanirodhak key roop mein upayog key liye vikas key tahat haye, vishesh roop seey purushon key liye ack janm niyantran goli key roop mein. ack maheene key liye prati dinn ack baar munh seey lene parr purushon mein testicular testosterone utpaadan koo gaharaai seey aur teji seey ulatane key liye dawa paaee gaee haye. maukhik dee. aim. aeye. yuu. key saath praapt testosterone key parisanchari star shalya chikitsa key saath ausatan dekhe jaane vaale staron key barabar they (dee. aim. aeye. yuu. key liye 13.4 ng/dee. ell., castration key liye 15 ng/dee. ell.). dee. aim. aeye. yuu. key bund honey key baad, testosterone kaa star kuchh dinon key bheetar thheek honah shuru hoe gayaa aur ack maheene key bheetar samanya star parr pahunch gayaa. purushon mein shukranujanan aur prajanan kshamata key liye vrishan testosterone kaa utpaadan aavashyak haye. shukranujanan key daman aur purushon mein dee. aim. aeye. yuu. key vaastavik garbhanirodhak prabhaavon kaa abhee taka naidaanik roop seey mulyankan naheen kiya gayaa haye, lekin dawa kii garbhanirodhak prabhavsheelta kii pushti karane key liye bhavishya key adhyayanon kii yojana banaai jaa rahee haye. purush garbhanirodhak key alawa, purushon mein cumm testosterone star key liye androgen pratisthaapan chikitsa mein dee. aim. aeye. yuu. key sambhaavit upayog mein bhee ruchi rahee haye.
dushprabhaav.
ack naidaanik adhyayan mein, ack maheene key liye purushon koo diye jaane parr dee. aim. aeye. yuu. koo achchi tarah seey sahan kiya gayaa. dushprabhavon mein halka vajan badhana (3 aur 9 pound key beach) aur aich. dee. ell. collestroll key star mein halki kamee shamil thee. koee badaa yaa gambhir dushprabhaav naheen dekhaa gayaa.
kyonki dee. aim. aeye. yuu. 5α-cumm naheen haye, testosterone key vipareet, isamen khopadi key baalon key jhadane kaa cumm jokhim hoe sakata haye.
astrogen kaa star cumm honah.
kyonki dee. aim. aeye. yuu. testosterone key star koo dabaata haye aur purushon mein astrogen key star koo badhaata haye lekin isaki apani koee astrogenic gatividhi naheen haye, yeh yaun akshamta (ee.) jaise cumm astrogen key star key lakshnon kaa jokhim paida curr sakata haye.jee., sex drive mein kamee, erectile function mein kamee) aur austeoporosis. yaun kaary mein kamee aur huddy key khanij ghanatva mein kamee nikatata seey sambandhit dawa trestolone key saath dekhi gaee haye, jisamen dee. aim. aeye. yuu. key samaan astrogenicta cumm haye.
yakrit vishaaktata.
testosterone key vipareet lekin isi tarah 17α-alkited aas jaise methyltestosterone (17α-methyltestosterone), dee. aim. aeye. yuu. koo sambhaavit yakrit vishaaktata key sanket dene vaale kuchh prabhaav paida karane key liye paaya gayaa haye jaba ise jaanvaron koo maukhik roop seey diyaa gayaa thaa. haalaanki, methyltestosterone key prabhaavon kii tulanaa mein prabhaav kaafee cumm they. dee. aim. aeye. yuu. aur trestolone (7α-methyl-19-nortestosterone) donon ney yakrit vishaaktata key sambhaavit sanket dikhaae, jabaki 11β-methyl-19-nortestosterone 17β-dodesilcarbonate ney kuchh aise prabhaav naheen dikhaae, yeh sujhaav dete hue kii dee. aim. aeye. yuu. aur trestolone kaa see. 7α methyl samooh unaki yakrit vishaaktata kshamata mein ack mahatvapurna yogdan kaarak hoe sakata haye. halanki, kissy bhee mamle mein, ack naidaanik adhyayan mein, purushon koo ack maheene key liye diye jaane parr dee. aim. aeye. yuu. yakrit aur gurde key kaary key mamle mein surakshit paaya gayaa.
pharmacology.
pharmacodynamics.
dee. aim. aeye. yuu. ack androgen ester haye, vishesh roop seey dimethendrolone kaa ester haye, aur shareer mein dimethendrolone key ack prodrug key roop mein kaary kartaa haye. jaise, yeh ack aas, yaa androgen receptor kaa ack agonist haye, aur ack progestogen, yaa progesterone receptor kaa ack agonist bhee haye. inn gatividhiyon key kaaran, dee. aim. aeye. yuu. mein shaktishali antigonadotropic prabhaav hotey hain, aur yeh testosterone key star koo shaktishali roop seey dabaane mein saksham hotaa haye. isake parinamswarup shukranujanan kaa daman hotaa haye aur purushon mein isake harmonal garbhanirodhak prabhaavon key liye jimmedaar hotaa haye. dawa sugandhit naheen haye aur isamen koee astrogenic gatividhi naheen haye. isake alawa, yeh 5α-reductase key liye ack substrate naheen haye aur isaliye twacha, baal rome aur prostate granthi jaise 5α-reductase koo vyakt karane vaale ootakon mein shaktishali yaa nishkriya naheen haye. jaise, dee. aim. aeye. yuu. mein androgenic dushprabhavon aur androgen-nirbhar sthitiyon jaise kii munhaase, khopadi key baalon kaa jhadana, shareer key baalon kaa vikas, saumya prostatic hyperplasia, aur testosterone aur kuchh anya aeye. aeye. aiss. key saapeksh prostate cancer kaa jokhim cumm hoe sakata haye.
pharmacokinetics.
purushon mein dee. aim. aeye. yuu. key ack pharmacokinetic adhyayan mein paaya gayaa kii kewal 2 seey 3 pratishat dawa koo dimethendrolone mein hydrolyse kiya gayaa thaa jaba ise capsule mein pouder key roop mein maukhik roop seey diyaa gayaa thaa. isake vipareet, testosterone mein testosterone kaa apghataniya jall apghatan teji seey hotaa haye aur poorna prateet hotaa haye. testosterone undecanoate key saapeksh dee. aim. aeye. yuu. key saath roopaantaran dakshata mein antar isake atirikt see7α aur see11β methyl samoohon key kaaran dee. aim. aeye. yuu. mein steric baadha key liye jimmedaar haye. halanki dimethendrolone mein dee. aim. aeye. yuu. kaa jall apghatan bahut seemit thaa, phir bhee yeh mulyankan kii gaee khuraak parr khuraak-nirbhar javic prabhaav paida karane key liye paryaapt thaa, jisamen lutinising harmon aur testosterone key star kaa prativarti daman shamil thaa. baad key ack pharmacokinetic adhyayan mein paaya gayaa kii dee. aim. aeye. yuu. key dimethendrolone mein roopaantaran mein sudhaar huaa jaba dawa koo capsule mein pouder key vipareet capsule mein arandi key tail/benzyl benzoate yaa ack swa-imulsifying dawa vitaran pranali mein maukhik roop seey vitarit kiya gayaa thaa.
rasayan vigyaan.
dimethendrolone undecanoate, jise 7α, 11β-diamethyl-19-nortestosterone 17β-undecanoate yaa 7α, 11β-dimethylster-4-aine-17β-ol-3-ack 17β-undecanoate key roop mein bhee jaanaa jaataa haye, ack synthetic astrain steroid haye aur 19-nortestosterone kaa ack gair-17α-alkylated vyutpann haye. yeh dimethendrolone (7α, 11β-diamethyl-19-nortestosterone) kaa c17β undeconoate (undecillate) ester haye. dimethendrolone key anya ester, jaise dimethendrolone busiclate (see. dee. bee.-4386aeye) aur dimethendrolone dodesilcarbonate (see. dee. bee.-4730) bhee vikasit kiye gaye hain. nikatata seey sambandhit aas key anuroop ester mein trestolone acetate (7α-methyl-19-nortestosterone 17β-acetate) aur 11β-methyl-19-nortestosterone 17β-dodesilcarbonate shamil hain.
itihas.
dimethendrolone key liye ack patent 1997 mein daayar kiya gayaa thaa aur 1999 mein diyaa gayaa thaa. baad mein, dee. aim. aeye. yuu aur dimethendrolone busiclate key liye ack patent 2002 mein daayar kiya gayaa thaa aur 2003 mein sanyukt raajya sarkaar koo diyaa gayaa thaa. dee. aim. yuu. koo rashtriya baal swaasthya aur maanav vikas sansthaan kii garbhanirodhak vikas shakha dwara code naam see. dee. bee-4521 key tahat vikasit kiya gayaa thaa, joe sanyukt raajya america key swaasthya aur maanav seva vibhaag mein rashtriya swaasthya sansthanon mein seey ack haye. purushon mein dee. aim. aeye. yuu. kaa pahala naidaanik adhyayan 2014 (ekal-khuraak), 2015 (ekal-khuraak), aur 2018 (ack maheene key liye nirantar) mein prakaashit kiya gayaa thaa.

