mitsunobu pratikriya

mitsunobu pratikriya ack carbonic pratikriya haye joe ack sharaab koo vibhinn prakaar key karyatmak samoohon mein parivartit karati haye, jaise kii ack ester, triphenylphosphine aur ack azodicarboxylate jaise diethyl azodicarboxylate (mrit) yaa disopropyl azodicarboxylate (died) kaa upayog karke. halanki mrit aur died kaa sabse adhik upayog kiya jaataa haye, lekin vibhinn prakaar key anya azodicarboxylate upalabdh hain joe ack aasaan workup aur/yaa shuddhikaran kii suvidha pradaan karate hain aur kuchh mamalon mein, adhik buniyaadi nucleophile key upayog kii suvidha pradaan karate hain. isaki khoj oyo mitsunobu (1934-2003) dwara kii gaee thee. ack vishisht protocol mein, ack tetrahydrophuran yaa anya upayukt vilaayak (ee.jee. diethyl eather), burf-snan kaa upayog karke 0 degree celsius taka thandaa karein, dheere-dheere mrit koo thuff mein ghol dein, phir kaee ghanton key liye kamare key tapman parr hilaaen. alcohol phosphine key saath pratikriya karke ack achchha chhodane vaalaa samooh banaata haye aur phir classic aiss. aine. 2 fashion mein stereochemistry key vyutkram seey gujarta haye kyonki nucleophile ise visthaapit kartaa haye. ack samanya dushprabhaav taba utpann hotaa haye jaba azodicarboxylate vaanchhit nucleophile key bajaay chhodane vaale samooh koo visthaapit kartaa haye. aisaa taba hotaa haye jaba nucleophile paryaapt amleeya naheen haye (pee. key. aeye. 13 seey badaa) yaa steric yaa electronic baadhaon key kaaran paryaapt nucleophilic naheen haye. nitrogen nucleophile kaa upayog karke iss pratikriya kii bhinnata koo fukuyama-mitsunobu key roop mein jaanaa jaataa haye.
kaee sameekshaaen prakaashit kii gaee hain.
pratikriya tantra.
mitsunobu pratikriya kaa pratikriya tantra kaafee jatil haye. madhyasthon kii pehchaan aur unaki bhoomikaaen bahas kaa vishay rahee hain.
shuru mein, triphenyl phosphine (2) diethyl azodicarboxylate (1) parr ack nucleophilic hamla kartaa haye joe ack beaten madhyavarti 3 kaa utpaadan kartaa haye, joe carboxylic acid (4) koo aayan jodee 5 banaane key liye deprotonate kartaa haye. aayan jodee 5 kaa gathan bahut tej hotaa haye. 
tantra key dusare charan koo phosphorus-kendrit honey kaa prastaav haye, mrit koo hydrazine mein parivartit curr diyaa gayaa haye. madhyavarti 8-11 kaa anupaat aur antar-roopaantaran carboxylic acid pee. key. aeye. aur vilaayak dhruviyata parr nirbhar kartaa haye. halanki kaee phosphorus madhyavarti maujood hain, madhyavarti 8 parr carboxylate aayan kaa hamla vaanchhit utpaad 12 aur triphenylphosphine oxide (13) banaane kaa ekmatra utpaadak maarg haye.
oxyphosphonium madhyavarti 8 kaa gathan dheema hotaa haye aur alcoxide dwara sugam hotaa haye. isaliye, pratikriya kii samagr darr carboxylate kshaariyata aur vilayan dwara niyantrit hoti haye.
abhikarmakon key sanyojan kaa crum.
mitsunobu pratikriya key abhikarmakon key sanyojan kaa crum mahatvapurna hoe sakata haye. aam taur parr, ack tetrahydrophuran yaa anya upayukt vilaayak (ee.jee. diethyl eather), burf-snan kaa upayog karke 0 degree celsius taka thandaa karein, dheere-dheere mrit koo thuff mein ghol dein, phir kaee ghanton key liye kamare key tapman parr hilaaen. yadi yeh asafal rahata haye, tou beaten koo pahale seey taiyar karane seey behtar parinam mill sakate hain. beaten koo purvanirdhaarit karane key liye, 0 degree celsius parr tetrahydrophuran mein triphenylphosphine mein mrit jodein, usake baad sharaab aur anta mein acid jodein.
vividhataaen.
anya nucleophilic karyatmak samooh.
carboxylic acid key alawa kaee anya karyatmak samooh nucleophile key roop mein kaam curr sakate hain. pratikriya key safal honey key liye, nucleophile mein 15 seey cumm pee. key. aeye. honah chaahiye.
sanshodhan.
utpaad key prithakkaran koo saral banaane aur itane adhik rasayanik apashisht key utpaadan seey bachane key liye mool abhikarmak sanyojan mein kaee sanshodhan vikasit kiye gaye hain. mitsunobu pratikriya kii ack bhinnata raal-baddh triphenylphosphine kaa upayog karati haye aur mrit key bajaay dee-"turt"-butylasodicarboxytol kaa upayog karati haye. aukseekrit triphenylphosphine raal koo nispandan dwara hataaya jaa sakata haye, aur dye-"turt"-butylasodicarboxytol upotpaad koo trifluoroacetic acid key saath upchaar dwara hataaya jaataa haye. broose aich. lipshoots ney mrit, dee-(4-chlorobenzyl) azodicarboxylate (dee. see. aeye. dee.) kaa ack vikalp vikasit kiya haye jahan hydrazine upa-utpaad koo nispandan dwara aasaani seey hataaya jaa sakata haye aur dee. see. aeye. dee. mein vaapas punarnaveenikaran kiya jaa sakata haye.
ack sanshodhan bhee bataaya gayaa haye jisamen mrit kaa upayog utprerak banaam stoichiometric matra mein kiya jaa sakata haye, haalaanki iss prakriya key liye hydrazine upa-utpaad koo vaapas mrit karane key liye stoichiometric (diasetoxiodo) benzene key upayog kii aavashyakta hoti haye.
denton aur saha-karmchaariyon ney mitsunobu pratikriya key ack redox-neutral sanskaran kii soochana dee haye joe substrate koo sakriya karane key liye ack phosphorus (iii) utprerak koo niyojit kartaa haye, nucleophilic hamale mein vyutkram sunishchit kartaa haye, aur paani key upa-utpaad koo hataane key liye ack deane-stark trap kaa upayog kartaa haye.
phosphoran abhikarmak.
sunami "aadi."yeh dikhaaya gayaa haye kii koee bhee triphenylphosphine aur diethyl azodicarboxylate koo ack abhikarmak mein jodd sakata haih ack phosphorene yelide. donon (sinomethylene) trimethylphosphorene (see. aim. aim. pee., aar = mee) aur (sinomethylene) tributylphosphorene (see. aim. bee. pee., aar = bee. yuu.) vishesh roop seey prabhaavi saabit hue hain.
yelide cumm karane vaale agent aur aadhar donon key roop mein kaary kartaa haye. upotpaad acetonitrile (6) aur trialkilfosphine oxide (8) hain.
upayog karein.
mitsunobu pratikriya koo eril eather key sanshleshan mein lagu kiya gayaa haih
inn vishesh abhikarakon key saath mrit key saath roopaantaran whiffle hoe jaataa haye kyonki hydroxyl samooh kewal kamjor amleeya hotaa haye. isake bajaay sambandhit "1,1 '-(azodicarbonyl) dipiperidine" (adap) kaa upayog kiya jaataa haye jiska beaten madhyavarti ack majboot aadhar haye. phosphine ack bahulak-samarthit triphenylphosphine (pee. aiss.-pee. aich. 3) haye.
pratikriya kaa upayog quinin, colchisin, saarain, morphin, stigmatellin, udistomine, oseltamivir, stricknin aur nuperamine koo sanshleshit karane key liye kiya gayaa haye.

