tetanic faid

tetanic faid yaa tou ack gair-vidhruvan tantrika-peshi avarodhak agent, yaa ack manspeshi joe ack charan 2 vidhruvan tantrika-peshi avarodhak agent key tahat haye, key prabhaav key tahat maanspeshiyon kii ack uttejit sambhaavit uttejana seey ghatati maanspeshiyon kii hilaav pratikriya koo sandarbhit kartaa haye.
avalokan.
maanspeshiyon mein ack uttejak sanket koo sthanantarit karane key liye, ack sanket koo poorv-sanyugma tantrika key akshatantu terminal seey paar karna chaahiye, sanyugma vikhand key paar jaanaa chaahiye aur vaanchhit prabhaav paida karane key liye anuyugma key baad key snaayu ootak kii motor aind plate mein sahee teevrata parr sahee tareeke seey praapt kiya jaanaa chaahiye. presineptic neuron koo chhodane vaalaa sanket acetylcholine (aeye. see. aich.) key roop mein hotaa haye, ack anu joe neuron key antim chhor parr sangraheet putikaon seey chhoda jaataa haye. aich synaptic daraar key sthaan key paar, motor aind plate key sarcolema parr ack aich receptors taka yatra kartaa haye. isake prabhaav key turant baad, aichi koo enzymatic acetylcholinesterase dwara apghatit kiya jaa rhaa haye.
aich receptor ack ligand gated channel haye joe ack baar aich seey bandha huaa haye, ack sanrachanaatmak parivartan seey gujarta haye joe calcium, sodium aur potasium key pravaah koo unake sambandhit dhaal seey neeche karane kii anumati detaa haye. paryaapt badey aayan parivartan mein ack vidyut rasayanik kshamata banegi, jise enduplate kshamata (ee. pee. pee.) kahaa jaataa haye. sodium chainalon key madhyam seey maanspeshiyon key tantuon koo prabhaavit karane key liye ee. pee. pee. sanket koo motor aind plate key madhyam seey aur tii-tubuls mein prasaarit kiya jaayega. inn sodium chainalon mein ack sankshipt sakriyan vindo hoti haye, jisake baad way taba taka nishkriya hoe jaate hain jaba taka kii antim plate kshamata koo aadhaarbhut star parr bahaal naheen curr diyaa jaataa haye.
maanspeshiyon key ootak mein tetani key liye pratikriyaaen.
neuromuscular blocking agent key binaa.
uttejit uttejana mein tetani, jaisa kii morgan aur mikhail key naidaanik sangyaaharan vigyaan mein 50 aur 100 heartz key beach nirantar uttejana key ~ 5 sekand key roop mein paribhaashit kiya gayaa haye. binaa kissy tantrika-peshi avrodh key uttejana key liye maanspeshiyon key ootak kii pratikriya poore uttejana mein teevrata mein barabar honey chaahieh pahali maanspeshiyon kii hilna aur antim lagbhag samaan parimaan kaa honah chaahiye. chikitsakiya roop seey yeh maanspeshiyon kii uttejana kii avadhi key dauran samaan maanspeshiyon key sankuchan key roop mein prastut hoga.
gair-vidhruvan tantrika-snaayu avarodhak agent key tahat.
gair-vidhruvan tantrika-peshi avarodhak agent (yaani rocuronium, vacuronium) channel koo sakriya kiye binaa aich receptor key saath baatchit karate hain, saath hii saath acetylcholine key bandhan koo rokte hain. yeh poorv-sansoochak neuron seey sanket prasaar koo avaruddh kartaa haye, aur sankendrak daraar seey uttejak sanket key pargaman koo alag kartaa haye.
ack gair-vidhruvan tantrika-peshi avarodhak agents key saath upchaarit maanspeshiyon key ootak ack tetanic faid key roop mein ack soochak pratikriya kaa utpaadan karenge, tetanic uttejana key liye ack ghatati pratikriya jahaan praarambhik teevrata sabse adhik hogi, aur nimnalikhit pratikriya kii cumm aur cumm taakat dikhaayenge.
kuchh aankadon seey pataa chalata haye kii yeh pratikriya poorv-sanyugma tantrika parr gair-vidhruvan tantrika-snaayu avarodhak agents key prabhaav key kaaran hoti haye, jisase tetanic uttejana key dauran daraar mein cumm acetylcholine sraavit hotaa haye. samanya maanspeshiyon mein aich kii ootak rihaai sakaratmak pratikriya key tareeke seey poorv-sanyugma tantrika key akshatantu seey aich kii adhik rihaai koo uttejit karane kaa kaam karati haye. ack gair-vidhruvan tantrika-peshi avarodhak agent key tahat ootak mein, synaptic daraar mein chhode jaane vaale aich key star koo bahut cumm curr detaa haye.
vidhruvan tantrika-peshi avarodhak agent key tahat.
vidhruvan tantrika-peshi avarodhak agent (yaani sasinilkolin) acetylcholine key vipareet, aich receptor seey bandhkar aur ise sakriya karke apane prabhaav koo niyojit karate hain, halanki, dawa teji seey acetylcholinesterase dwara avakramit naheen hoti haye. sasinilkolin lambe samay taka uchch sandrata mein failata haye jaba taka kii yeh ack alag enzyme (seudocolinesteres) dwara plasma aur yakrit mein apghatit naheen hoe jaataa haye. yeh aich receptor koo sakriya karna jaari rakhta haye, aur sodium chainalon koo unaki sakriya sthiti mein thheek honey seey rokta haye. yeh maanspeshiyon koo aaraam detaa haye aur ise charan 1 block kahaa jaataa haye, naidaanik roop seey yeh tetanic uttejana key dauran ack cumm khinchaav pratikriya key roop mein prastut hoga.
charan 1 block tetanic uttejana key tahat feaky naheen dikhaata haye. vidhruvan tantrika-peshi avarodhak agent key aage key prashaasan key saath, ack prabhaav joe gair-vidhruvan tantrika-peshi avarodhak agents key liye maanspeshiyon kii pratikriya key samaan haye, dekhaa jaa sakata haye. yeh pratikriya, jise charan 2 khand kahaa jaataa haye, tetanic uttejana key tahat samaan faid kaa pradarshan karegi, tetanic uttejana key liye ack ghatati pratikriya jahaan praarambhik pratikriya sabse majboot hogi, aur cumm aur cumm pratikriya teevrata kaa utpaadan karegi.

