vaaee-38

vaaee-38 ack dwigunit maanav koshika rekha haye joe 3 maheene key garbh mahila bhroon key fefadon key ootak seey praapt fibroblast seey bunny haye. bhroon 1963 mein ack swedish mahila key vaikalpik garbhpaat seey aaya thaa. koshika rekha koo usee varsh leonard heflick dwara alag kiya gayaa thaa, aur vaigyaanik anusandhaan mein badey paimaane parr upayog kiya gayaa haye, jisamen aanvik jeev vigyaan mein mahatvapurna siddhanton koo vikasit karane aur umr badhane seey laker adhikansh maanav virus teekon key utpaadan taka key anuprayog hain. maanav virus vaccine utpaadan mein iss koshika line key upayog ney laakhon logon key jeevan koo bachaane kaa anuman haye.
itihas.
vaaee-38 koshika rekha pahale key kaam seey maanav koshika sanskritiyon koo badhaane vaale ghaas seey upaji haye.
1960 key dashak kii shuruat mein, philadelphia, pensylvania mein vistar sansthaan mein heflick aur unake sahayogi paul moored ney paaya kii jaba samanya maanav koshikaon koo ack freezer mein sangraheet kiya jaataa thaa, tou koshikaon koo doguna honey key star koo yaad aataa thaa jiss parr way sangraheet kiye jaate they aur jaba unakaa punargathan kiya jaataa thaa, tou usa star seey lagbhag 50 kull doubleling (bhroon key ootak seey praapt koshikaon key liye) mein vibhajit honah shuru hoe jaataa thaa. heflick ney nirdhaarit kiya kii samanya koshikaaen dheere-dheere vibhajan key sanketon kaa anubhav karati hain, pahale vibhajan koo poori tarah seey rokane seey pahale dheemi hoe jaati hain. yeh khoj heflick seema kaa aadhar haye, joe koshika vibhajan bund honey seey pahale ack samanya maanav koshika aabaadi key vibhajit honey kii sankhya koo nirdisht karati haye. heflick kii khoj ney baad mein telomerase kii javic bhoomikaon key nirdhaaran mein yogdan diyaa. heflick ney daavaa kiya kii samanya maanav koshikaon kii pratikriti banaane kii seemit kshamata koshikiya star parr umr badhane yaa vriddhavastha kii abhivyakti thee.
shodh kii iss avadhi key dauran, heflick ney yeh bhee paaya kii yadi koshikaon koo ack freezer mein thheek seey sangraheet kiya jaataa haye, tou koshikaaen vyavharya rahengi aur ack hii praarambhik sanskriti seey badee sankhya mein koshikaon kaa utpaadan kiya jaa sakata haye. koshika upbhedon mein seey ack joe heflick koo alag kartaa haye, jise unhone vaaee-38 naam diyaa, dooshit karane vaale virus seey mukt paaya gayaa, joe taba virus vaccine utpaadan key liye upayog kii jaane vaali praathamik bandar gurde kii koshikaon key vipareet thaa. isake alawa, vaaee-38 koshikaon koo jamaaya jaa sakata haye, phir pighlaya jaa sakata haye aur poori tarah seey pareekshan kiya jaa sakata haye. inn laabhon key kaaran doubleu. aaee.-38 ney maanav virus vaccine utpaadan key liye praathamik bandar gurde koshikaon koo jaldi seey badal diyaa. doubleu. aaee.-38 kaa upayog samanya maanav koshika jeev vigyaan key kaee pahaluon parr shodh key liye bhee kiya gayaa haye.
anuprayog.
doubleu. aaee.-38 praarambhik shodhkartaon key liye amulya thaa, vishesh roop seey joe vishaanu vigyaan aur pratiraksha vigyaan kaa adhyayan curr rahey they, kyonki yeh samanya maanav ootak kii ack aasaani seey upalabdh koshika rekha thee. hella koshika rekha key vipareet, joe cancer koshikaaen theen, vaaee-38 ack samanya maanav koshika aabaadi thee. duniya bhar kii prayogshalaon mein shodhkartaon ney taba seey apani khojon mein doubleu. aaee.-38 kaa upayog kiya haye, vishesh roop seey maanav virus teekon key vikas mein. sankramit vaaee-38 koshikaaen virus kaa sraav karati hain, aur vaanijyik utpaadan key liye upayukt badee matra mein samvardhit kii jaa sakati hain.
vaaee-38 mein utpaadit virus teekon ney bimari koo rokaa haye yaa arabon logon kii zaan bachaai haye. vaaee-38 mein utpaadit teekon mein adenovirus, rubela, khasra, galgund, varicella zoster, polyovirus, hepatitis aeye aur rabies key khilaf banaae gaye teeke shamil hain.
genome anukram.
vaaee-38 koshika rekha pahali koshika rekhaaon mein seey ack thee jiska "dwigunit" genome anukramit kiya gayaa thaa. yeh mahatvapurna haye kyonki adhikansh maanav genome anukram gunasutra star taka hull naheen kiye gaye hain, yaani, yeh kaafee hudd taka spasht naheen rhaa haye kii dou chromatids mein seey kaun saa aanuvanshik sanskaran haye. prayogaatmak adhyayanon key liye ack mahatvapurna koshika rekha honey key alawa (ee.jee. umr badhane parr), aisaa maanaa jaataa haye kii doubleu. aaee.-38 line mool roop seey 1961 mein sthaapit honey key baad seey dwigunit bunny hui haye. lagbhag 60 saal baad, soifer aur anya dwara caryotyping. (2020) ney dikhaaya kii vaaee-38 genome ney sthanantaran jaise pramukh punarvyavastha praapt naheen kii haye. isase bhee mahatvapurna baat yeh haye kii dee novo charanbaddh assembly iss baat kii pushti karati haye kii genome vaastav mein dwigunit rhaa haye aur poore samay mein apani vishamyugmata koo banaae rakhaa haye. isaliye yeh genome anukraman key liye ack achchha model haye aur ack anya sandarbh genome key roop mein kaary kartaa haye.

