
pendrin

pendrin ack aayan vinimay protein haye jise manushyon mein "slc26aeye4" jeane (solute carrier parivaar 26, sadasya 4) dwara kootbaddh kiya jaataa haye.
pendrin koo shuru mein ack sodium-swatantra chloride-iodide vinimaayak key roop mein pahachaana gayaa thaa, baad key adhyayanon seey pataa chalata haye kii yeh formatt aur bicarbonate koo bhee substrate key roop mein sweekaar kartaa haye. pendrin laal rakt koshikaon mein paae jaane vaale baind 3 parivahan protein key samaan haye. pendrin vaha protein haye joe pendred syndrome mein utparivartit hotaa haye, joe ack autosomal aprabhaavi vikaar haye jisaki visheshta samvedi shravan haani, galgand aur ack sakaratmak perchlorate pareekshan dwara pataa lagaane yogya aanshik angeekaran samasya haye.
pendrin meethe paani kii machhali kii chloride koshikaon mein ack plasma jhilli key paar bicarbonate (aich. see. oh. 3-) key liye chloride (see. ell.-) key vidyut tatasth vinimay key liye jimmedaar haye.
phylogenetic vishleshan dwara, pendrin koo baal koshikaon yaa aantarik kaana mein corty key anga parr maujood prestine kaa ack karibi rishtedaar paaya gayaa haye. prestine mukhya roop seey ack electromechanical transducer haye lekin pendrin ack aayan transporter haye.
kaary.
pendrin ack aayan vinimaayak haye joe shareer mein kaee prakaar kii koshikaon mein paaya jaataa haye. aantarik kaana aur thyroid mein pendrin abhivyakti key uchch star kii pehchaan kii gaee haye. thyroid mein, pendrin thyrocyte kii epical jhilli mein iodide key pravaah key ack ghatak kaa madhyasthata kartaa haye, joe thyroid harmon key gathan key liye mahatvapurna haye. aantarik kaana mein pendrin kaa sateek kaary spasht naheen haye; haalaanki, pendrin chloride-bicarbonate vinimaayak key roop mein acid-bases santulan mein ack bhoomika nibha sakata haye, chloride-formatt vinimaayak key roop mein kaary karane kii apani kshamata key madhyam seey aayatan homeostasis koo niyantrit curr sakata haye yaa apratyaksh roop seey endolymph kii calcium sandrata koo sanshodhit curr sakata haye. pendrin gurde mein bhee vyakt kiya jaataa haye, aur cortical sangrah nalika mein interclated koshikaon kii aabaadi kii epical jhilli mein sthaaniyakrit kiya gayaa haye jahaan yeh bicarbonate sraav mein shamil haye.
naidaanik mahatva.
iss jeane mein utparivartan pendred syndrome seey judey hotey hain, joe syndromic badhirata kaa sabse aam roop haye, joe ack autosomal-recessive bimari haye. pendred syndrome kii visheshta thyroid goiter aur vestibular aquaduct kaa badhana haye jisake parinamswarup badhirata hoti haye; haalaanki, gurde mein vyakt honey key bavjood, pendred syndrome vaale vyaktiyon mein gurde seey sambandhit acid-bases, yaa mool sthitiyon key tahat matra asamanyata naheen dikhaai detee haye. yeh sambhavatah gurde mein anya bicarbonate yaa chloride transporters kaa parinam haye joe pendrin kaary key kissy bhee nuksan kii bharpai karate hain. kewal namak kii kamee yaa chayapachaya kshaar kii charam sthitiyon mein, yaa sodium-chloride cottransporter key nishkriya honey key saath, inn rogiyon mein taral aur electrolyte vikaar prakat hotey hain. slc26aeye4 slc26aeye3 jeane key liye atyadhik samroop haye; unaki samaan genomic sanrachanaaen hain aur yeh jeane slc26aeye3 jeane key 3 'parr sthit haye. encoded protein mein sulfate transporter key liye samroopata hoti haye.
pendrin kii ack aur cumm samajhi gaee bhoomika vayumarg atee pratikriya aur soojan mein haye, jaisa kii asthama key hamalon aur allergy pratikriyaon key dauran hotaa haye. fefadon mein pendrin kii abhivyakti allergy aur il-13 kii uchch sandrata kii pratikriya mein badh jaati haye, aur pendrin kii adhik abhivyakti key parinamswarup vayumarg kii soojan, atee sakriyata aur shleshma utpaadan mein vriddhi hoti haye. yeye lakshan vayumarg kii satah key taral mein aayan sandrata parr pendrin key prabhaav key parinamswarup hoe sakate hain, jisase sambhavatah taral cumm hydrated hoe sakata haye.

