
7-alfa-hydroxycolest-4-aine-3-ack 12-alfa-hydroxylase

7-alfa-hydroxycolest-4-aine-3-ack 12-alfa-hydroxylase (, pahale) ack enzyme haye joe rasayanik pratikriya koo utprerit kartaa haih
iss enzyme key 4 substrate 7-alfa-hydroxycolest-4-aine-3-vann (7-alfa-hydroxy-4-colleston-3-vann, naduff, aich + aur oh 2 hain. isake utpaad 7-alfa, 12-alfa-dihydroxicolest-4-aine-3-vann, nadpi + aur aich2oh hain.
2015 seey, enzyme koo 5β-colleston-3α, 7α-diol 12α-hydroxylase key vyavasthit naam key saath vargeekrit kiya gayaa haye. anya naam jinka upayog kiya gayaa haye unamen 7-alfa-hydroxycolest-4-aine-3-vann, naadfah oxygen oxidoriductase (12-alfa-hydroxylating), 7-alfa-hydroxy-4-colleston-3-ack 12-alfa-monoxyginase, sipe 12, sterol 12-alfa-hydroxylase (aspasht), aur hco 12-alfa-hydroxylase shamil hain.
yeh enzyme oxidoriductase key parivaar seey sambandhit haye, vishesh roop seey joe yugmit daataon parr kaary karate hain, jisamen oxidant key roop mein oh2 aur oxygen kaa samavesh yaa kamee hoti haye. nigamit oxygen koo oh2 seey praapt karane kii aavashyakta naheen haye, jisamen ack daataa key roop mein naadh yaa naadh key saath, aur dusare daataa mein oxygen key ack paramanu koo shamil kiya jaanaa chaahiye. ise 1992 mein khargosh key yakrit key sookshmajeevon seey shuddh aur visheshta dee gaee thee aur 1996 mein iska pratiroopan aur anukraman kiya gayaa thaa. isaki sanrachana 39 pratishat maanav prostacycline synthes (sipe8) key samaan aur 31 pratishat collestroll 7 alfa-hydroxylase (sipe7) key samaan thee.
iss enzymatic gatividhi koo abb "sipe8bee1" jeane key utpaad dwara kiya jaataa haye. iss charan seey pitt aml, colic aml kaa nirmaan hotaa haye. colic acid ack 3,7,12 trie-hydroxy pitt acid haye aur manushyon aur kaee anya jaanvaron mein pramukh pitt acid mein seey ack haye. iss enzyme kii gatividhi manushyon mein colic aur chenodioxicolic acid key beach santulan nirdhaarit karati haye.

