
parivahan 1

transportin-1 (yaa importin-beeta 2) ack protein haye jise manushyon mein "tnpo1" jeane dwara kootbaddh kiya jaataa haye.
kaary.
yeh protein ack caryopherin haye joe naabhikiya protein koo naabhikiya protein koo lakshit karane key liye naabhikiya sthaaniyakaran anukram key saath baatchit kartaa haye. shaastriya caryopherin receptor complexes, jaise kii complexes joe importin-beeta1 (jeane kpnb1 dwara encode kiya gayaa) kaa upayog kartaa haye, ack alfa upghatak kaa ack heterodymer haye joe paramanu sthaaniyakaran sanket aur ack beeta upghatak koo pahachaantaa haye joe nucleoporin parr parisar koo rokta haye. haalaanki, parivahan-1 seedhe malvahak protein seey juda sakata haye aur ise karane key liye ayaat alfa upa-ikai kii aavashyakta naheen hoe sakati haye.
parivahan-1 koo anya aayaton key samaan paramanu parivahan karane key liye usee pramukh tantra kaa upayog karane key liye socha jaataa haye. yeh nucleoporin key liye bandhan key madhyam seey paramanu chhidra parisar mein docking kaa madhyasthata kartaa haye aur baad mein ack oorjaa kii aavashyakta vaale tantra dwara chhidra key madhyam seey sthanantarit kiya jaataa haye. phir, naabhik mein pravaahit hotaa haye parivahan-1 seey, yeh maal seey alag hoe jaataa haye, aur parivahan-1 koo naabhik seey koshika dravya mein phir seey niryaat kiya jaataa haye jahaan jee. tii. pee. jall apghatan jaari hotaa haye. phir parivahan-1 nae maal koo baandhane key liye swatantra haye.
isake alawa, transportin-1 praathamik silium mein protein parivahan mein madad karane mein shamil haye. iss mamle mein parivahan-1 kaa kaary paramanu chhidra key madhyam seey naabhik mein protein leey jaane key samaan maanaa jaataa haye. parivahan-1 maal koo baandhata haye aur phir iss maal koo silium key aadhar parr ack chhidra seey gujarane mein madad curr rhaa haye. iss tantra mein runn aur nucleoporin bhee shamil hain.
iss jeane key vaikalpik vibhajan key parinamswarup dou pratilekh roop alag-alag protein koo encoding karate hain.
lakshya.
parivahan 1 (tii. aar. aine. 1) gair-shaastriya paramanu ayaat maarg kaa hissa haye. rangtapi hydrolysis cascade key sanyojan mein tii. aar. aine. 1 koshikaon key naabhik mein protein key chayan koo ayaat karane kaa kaary kartaa haye. inn lakshyon mein aam taur parr ack paay-motif hotaa haye jise anyatha aim9 paramanu sthaaniyakaran sanket key roop mein jaanaa jaataa haye. achchi tarah seey varnit udaharanon mein hnrnp aeye1 shamil haye.
1 mein parivahan kiye jaane vaale malvahak protein key prakaar mein aar. aine. aeye.-binding protein (jaise aich. aine. aar. aine. pee. aeye1 aur aich. aine. aar. aine. pee. aff) aur ribosomal protein bhee shamil hain.
naidaanik mahatva.
tii. aar. aine. 1 koo dou neurodegenerative rogon, arthaat amyotrophic lateral sclerosis aur frontotemporal dementia key rogjanan mein shamil kiya gayaa haye.
antahkriyaaen.
parivahan 1 koo nimn key saath antahkriya karate hue dikhaaya gayaa haih

