
prasavpurv steroid

prasavpurv steroid, jinhen prasavpurv corticosteroids key roop mein bhee jaanaa jaataa haye, garbhavati mahilaaon koo samay seey pahale janm kii ummeed mein dee jaane vaali davaaen hain. jaba prashaasit kiya jaataa haye, tou yeye steroid bhroon key fefadon kii paripakvata mein teji laate hain, joe shishu shwasan sankat syndrome aur shishu mrityu darr kii sambhavana koo cumm kartaa haye. manushyon parr iss corticosteroid upchaar kii prabhavsheelta kaa pahali baar 1972 mein surr graham liggins aur rose howy dwara bitamethasone kaa upayog karke ack yaadrichhik niyantran pareekshan key dauran pradarshan kiya gayaa thaa.
upayog karein.
samay seey pahale janm.
prasavpurv steroid koo shishu shwasan sankat syndrome kii ghatana aur mrityu darr koo cumm karane key liye dikhaaya gayaa haye, joe avikasit fefadon key kaaran honey vaali ack jeevan-dhamki vaali sthiti haye.
vartamaan sakshya bataate hain kii prasavpurv corticosteroids dene seey dair seey garbhpaat aur shishu kii mrityu kaa khatra cumm hoe jaataa haye. bachche mein shwasan sankat syndrome vikasit honey yaa janm key dauran yaa baad mein marane kii sambhavana bhee cumm hoti haye. jeevan key pahale dou dinon mein unake antahshira raktasraav (mastishk kaa raktasraav), necrotising enterocolitis (aantr key saath samasyaaen), yaa pranaaleegat sankraman (poore shareer koo prabhaavit karane vaale sankraman) honey kii sambhavana bhee cumm hoti haye.
steroid una mahilaaon kii sankhya mein vriddhi naheen karate hain joe bhroon jhilli (choreominionitis) yaa garbh (endometritis) key sankraman kaa vikas karati hain.
iss baat key majboot pramaan hain kii prasavpurv corticosteroids kaa ack ekal pathyakram (i.ee.24 milligram beeta-methasone yaa dexamethasone), jaba samay seey pahale janm kaa khatra hotaa haye (garbhavastha key 34 saptah seey cumm samay mein), tou sansaadhan star kii parwah kiye binaa bachche kii mrityu kaa khatra cumm hoe jaataa haye.
kaee baar garbhadhaaran.
kaee garbhadharanon key liye prasavpurv steroid prashaasan key parinamon koo paryaapt roop seey nirdhaarit karane key liye aage key shodh kiye jaane chaahiye. haalaanki, kuchh rashtriya naidaanik abhyaas dishanirdesh kaee baar garbh dhaaran karane kii parwah kiye binaa samay seey pahale janm key liye steroid key upayog kii sifarish karate hain.
jhilli kaa samay seey pahale tootana.
prasavpurv steroid koo bhee jhilli (pee. pro. aim.) key samay seey pahale tootane kii sthiti key ilaaj mein nishchit laabhkaari prabhaav dikhaane key liye dikhaaya gayaa haye. samay seey pahale janm parr isake prabhaavon key samaan, shodh sakshya bataate hain kii prome vaale rogiyon koo prasavpurv steroid kaa prashaasan navjat mrityu darr, antahshira raktasraav aur shwasan sankat syndrome key jokhim koo cumm kartaa haye.
pratikool prabhaav.
praarambhik shodh ney sujhaav diyaa haye kii prasavpurv corticosteroids key upayog seey deerghakaalik pratikool prabhaav parh sakate hain. jaanvaron mein, prasavpurv corticosteroid kaa upayog cardiometabolic pranali parr pratikool prabhaavon aur mastishk key vikas koo rokane key saath-saath smriti aur seekhane kii kathinaaiyon koo bhee kharaab kartaa haye. halanki yeh abhee taka nishchit naheen haye kii maanav bhroon inn samaan prabhaavon kaa anubhav karenge yaa naheen, kuchh saahityon mein paaya gayaa haye kii prasavpurv corticosteroids key saath ilaaj kiye gaye maanav samay seey pahale bhroon koo bachpan key dauran mansik aur vyavhaar sambandhi vikaaron key vikas kaa adhik khatra hoe sakata haye, kyonki yeye davaaen bhroon key mastishk mein pravesh karane mein saksham hain aur tantrika vikas koo prabhaavit curr sakati hain. manushyon aur jaanvaron donon mein, shodh ney sujhaav diyaa haye kii prasavpurv corticosteroids kii baar-baar khuraak seey deerghakaalik drishti aur shravan samasyaon kaa khatra badh sakata haye.
virodhabhas.
prasavpurv corticosteroids key prashaasan key liye virodhabhason mein shamil hainh
drugs.
corticosteroids janm seey pahale samay seey pahale bhroon mein fefadon key vikas koo protsaahit karate hain, aur 24 seey 48 ghanton key bheetar samay seey pahale bhroon key janm kii ummeed honey parr prashaasit kiye jaate hain. ishtatam laabh kii avadhi prashaasan key 24 ghante baad shuru hoti haye aur 7 dinon taka chalati haye. duniya key kuchh hisson mein, prasavpurv steroid kaa upayog garbhavastha key 36 saptah taka kiya jaataa haye. steroid key prashaasan aur delivery key beach kaa samay steroid kii prabhavsheelta koo badal sakata haye.
steroid kaa chayan.
samanya corticosteroids mein dexamethasone aur bitamethasone shamil hain. dexamethasone koo aksar isaki badhee hui prabhavkarita aur suraksha, vyaapak upalabdhata aur cumm laagat key kaaran baad vaale kii tulanaa mein anushansit kiya jaataa haye, jabaki beeta-methasone samay seey pahale bhroon mein mastishk key naram honey koo rokane mein behtar haye. donon davaaen kuchh samaantaon koo saajha karati hain, jisamen naal koo paar karane kii kshamata key saath-saath ack bahut hii samaan aanvik sanrachana bhee shamil haye. vaastav mein, dou steroid ack hii atirikt methyl samooh key liye samaan hain, joe kii bitamethasone parr haye. haalaanki bitamethasone kaa aadhaa jeevan badh gayaa haye, lekin koee mahatvapurna pramaan naheen haye joe ingit kartaa haye kii ack dusare seey behtar hoe sakata haye. iss vishay parr saahitya seemit aur asangat haye. ack cochrane sameeksha (2022) mein paaya gayaa kii yeh spasht naheen thaa kii kyaa mahatvapurna antar they, jabaki anya adhyayanon ney nirdhaarit kiya kii beeta-methasone key parinamswarup deerghakaalik parinamon mein sudhaar huaa.
kaarravaai kaa tantra.
behtar shwasan parinam utpann karane key liye, prasavpurv steroid type II pneumocytes naamak koshikaon parr kaary karate hain joe shishu fefadon key vayukosh key bheetar sthit hotey hain. glucocorticoid donon koshika paripakvata kii darr koo badhaate hain, saath hii surfactant key sanshleshan key liye aavashyak protein key liye aim. aar. aine. aeye. coding key utpaadan koo badhaate hain. surfactant ack phospholipid seey bharpur padaarth haye joe loach badhaane aur satah key tanaav koo cumm karane key liye fefadon dwara sraavit hotaa haye, jisake parinamswarup ventilation kii adhik kushal darr paida hoti haye. isake alawa, fefadon mein vayukosh key ander kii satah parr surfactant rekhaaen hoti hain aur isake parinamswarup, vayukosh koo saans chhodane key dauran girane seey rokta haye. choonki samay seey pahale paida honey vaale shishuon mein aksar aparipakva yaa apoorna roop seey vikasit fefde hotey hain, isaliye vayukosh kaa surfactant coating bhee isi tarah aparyaapt hotaa haye, jisake parinamswarup kharaab shwasan parinam yaa shwasan sankat syndrome kaa vikas hotaa haye. prasavpurv corticosteroids kaa prashaasan surfactant key utpaadan koo badhaata haye (janm key baad surfactant kaa upayog karane kii aavashyakta koo cumm kartaa haye), aur isaliye samay seey pahale shishuon key liye behtar swaasthya parinamon mein parinam detaa haye.
itihas.
1969 mein, ack chikitsa anusandhaan vaigyaanik graham liggins ney garbhavati bhed mein prasav key samay parr dexamethasone prashaasan key prabhaavon kii jaanch shuru kii. liggins ney iss prayog koo apani parikalpana koo saabit karane kii ummeed mein kiya kii bhroon, naa kii maan, shram koo prerit karane key liye jimmedaar haye. liggins ney paaya kii dexamethasone garbhavati bhed koo samay seey pahale janm dene kaa kaaran banaa, haalaanki, iss tathya key bavjood kii bhed kaa bachcha bahut samay seey pahale thaa, yeh jeevit janm diyaa gayaa thaa.
apane sahayogi, baal roga visheshagya rose howy kii madad seey, liggins ney 282 maanav mahilaaon key saath isi tarah kaa ack prayog kiya, jinamen seey sabhi koo samay seey pahale prasav honey kaa anuman thaa. iss praarambhik pareekshan seey pataa chalaa kii corticosteroids, vishesh roop seey beeta-methasone key prashaasan key parinamswarup tatkaal sudhaar hue joe saankhyikiya roop seey mahatvapurna they, jaise kih
inn nishkarshon koo pahali baar 1972 mein journal paediatrics mein prakaashit samay seey pahale shishuon mein shwasan sankat syndrome kii roktham key liye antipartum glucocorticoid upchaar key ack niyantrit pareekshan key lekh mein report kiya gayaa thaa. liggins aur howy key shodh ney saabit kiya kii prasavpurv corticosteroids koshikiya vibhedan koo prerit karke shwasan jatilataon aur shishu mrityu darr koo cumm karane mein saksham they, aur iss prakaar fefadon mein paripakvata. haalaanki, inn parinamon koo dou dashakon seey adhik samay baad taka sanyukt raajya america mein naidaanik abhyaas mein shamil naheen kiya gayaa thaa.

