
ralegrevir

raletegravir, jise brand naam icentress key tahat becha jaataa haye, ack antiretroviral dawa haye jiska upayog hiv/aids key ilaaj key liye anya davaaon key saath kiya jaataa haye. sambhaavit sampark key baad aich. aaee. vee. sankraman koo rokane key liye, iska upayog post exposure prophylaxis key hisse key roop mein bhee kiya jaa sakata haye. ise munh seey liya jaataa haye.
aam dushprabhavon mein neend mein pareshani, thakan mahsoos karna, matali, uchch rakt sharkara aur sirdard shamil hain. gambhir dushprabhavon mein stevens-johnson syndrome, maanspeshiyon key tootane aur yakrit kii samasyaon sahit allergy pratikriyaen shamil hoe sakati hain. yeh spasht naheen haye kii garbhavastha yaa stanpan key dauran upayog surakshit haye yaa naheen. raletegravir ack hiv integrage strand transfer inhibitor haye joe hiv integrage key kaary koo avaruddh kartaa haye joe viral pratikriti key liye aavashyak haye.
ralegravir koo 2007 mein sanyukt raajya america mein chikitsa upayog key liye manjuri dee gaee thee. yeh vishva swaasthya sangathan kii aavashyak davaaon kii soochi mein haye. lamywoodine/raletegravir, lamywoodine key saath ack sanyojan bhee upalabdh haye.
chikitsa upayog.
ralegravir koo shuru mein kewal una vyaktiyon mein upayog key liye anumodit kiya gayaa thaa jinake sankraman ney anya haart davaaon key liye pratirodhi saabit kiya haye. haalaanki, julaai 2009 mein, yuu.aiss. khaadya aur aushadhi prashaasan (aff. dee. aeye.) ney sabhi rogiyon mein upayog key liye raletegravir key liye vistaarit anumodan pradaan kiya. kissy bhee haart dawa key saath, hiv kii atyadhik utparivarti prakriti key kaaran, yadi monotherapy key roop mein upayog kiya jaataa haye tou ralegravir key sthaayitva dikhaane kii sambhavana naheen haye.
disambar 2011 mein, dou saal seey adhik umr key bachchon mein upayog key liye manjuri dee gaee, jise dou anya antiretroviral davaaon key saath prescription dwara dinn mein dou baar maukhik roop seey goli key roop mein liya jaataa haye taaki cocktail banaaya jaa sakey (vayaskon aur bachchon key liye adhikansh anty-hiv davaaen inn cocktail kaa upayog karati hain). raletegravir chabaane yogya roop mein upalabdh haye, lekin kyonki dou goli sutrikaran paraspar vinimeya naheen hain, isaliye chabaane yogya goliyaan kewal dou seey 11 bachchon mein upayog key liye anumodit hain. badey kishore vayask sutrikaran kaa upayog karenge.
prabhavkarita.
sanyojan chikitsa key hisse key roop mein dawa key ack adhyayan mein, raletegravir ney 24 aur 48 saptah mein affavirange key samaan shaktishali aur tikaau antiretroviral gatividhi kaa pradarshan kiya, lekin adhik teji seey pataa lagaane key liye hiv-1 rna star koo praapt kiya. 24 aur 48 saptah key upchaar key baad, raletegravir key parinamswarup kull collestroll, cumm ghanatva vaale lipoprotein collestroll yaa triglycerides key seeram star mein vriddhi naheen hui.
dushprabhaav.
48 saptah kii avadhi taka key parikshanon mein aich. aaee. vee-1 sankraman key saath upchaar-anubhavi rogiyon mein anukoolit prishthabhoomi chikitsa upchaar key sanyojan mein upayog karane parr ralegravir koo aam taur parr achchi tarah seey sahan kiya jaataa thaa.
kaarravaai kaa tantra.
ack integrays avarodhak key roop mein, raletegravir integrays koo lakshit kartaa haye, retrovirus key liye samanya enzyme joe viral aanuvanshik samagri koo maanav gunasutron mein ekikrit kartaa haye, hiv sankraman model mein ack mahatvapurna kadam haye. dawa koo glucuronidation key madhyam seey chayapachaya kiya jaataa haye.
rasayan vigyaan.
raletegravir koo kaee tarikon seey sanshleshit kiya gayaa haye, jinaki sameeksha kii gaee haye.
isake nirmaan key liye upayog kii jaane vaali ack vidhi mein, 2-emino-2-methylpropanetrile koo 5-methyl-1,3,4-oxadiazole-2-carboxylic acid key acid chloride key saath pratikriya key roop mein n-methylmorpholine kaa upayog kiya jaataa haye. utpaad koo jaleey hydroxylamine key saath upchaarit kiya jaataa haye taaki ack amadoxime banaaya jaa sakey. dawa kaa kendriya pyrimidone valay taba banaaya jaataa haye jaba amadoxime diamethyl acetylenadicarboxylate key saath pratikriya kartaa haye. sanshleshan madhyavarti key shesh methyl ester koo 4-fluorobenzylamine key saath ack amide mein parivartit karke puuraa kiya jaataa haye, jisake baad trimethylsulfaxionimsonyme iodide kaa upayog karke methylation kiya jaataa haye. usa abhikarmak kaa upayog aavashyak rasayan-chayan sunishchit kartaa haye taaki pyrimidone key nitrogen paramanu parr methylation hoe.
itihas.
ralegravir octuber 2007 mein sanyukt raajya america mein anumodan praapt karane vaalaa pahala integrays avarodhak thaa.
ise merck dwara vikasit kiya gayaa thaa aur summa aur anya dwara report kiya gayaa thaa."aushadhiya rasayan vigyaan kii patrika mein.
shodh.
raletegravir hiv viral gatishilata aur kshay koo kaafee badal detaa haye aur iss kshetra mein aage kaa shodh jaari haye. naidaanik parikshanon mein raletegravir lene vaale rogiyon ney samaan roop seey shaktishali gair-nucleoside riverse transcriptase avarodhak yaa protease avarodhak lene vaalon kii tulanaa mein 50 pratiyon prati millilitre seey cumm viral load praapt kiye. viral load mein kamee mein iss saankhyikiya roop seey mahatvapurna antar key kaaran kuchh hiv shodhkartaon ney hiv viral gatishilata aur kshay key baare mein lambe samay seey rakhe gaye pratimanon parr sawal uthaana shuru curr diyaa haye. raletegravir kii avyakt viral jalashayon koo prabhaavit karane kii kshamata aur sambhavatah hiv key unmoolan mein sahaayata key baare mein shodh vartamaan mein jaari haye.
shodh key parinam 24 julaai, 2008 koo "nyu ingland journal off medicine" mein prakaashit hue they. lekhakon ney nishkarsh nikala kii "ralegravir plus anukoolit prishthabhoomi chikitsa ney cumm seey cumm 48 hafton key liye akele anukoolit prishthabhoomi chikitsa kii tulanaa mein behtar viral daman pradaan kiya."
maanav cytomegalovirus (aich. see. aim. vee.) parr shodh ney pradarshit kiya kii raletegravir herpesvirus kii viral pratikriti koo avaruddh curr sakata haye.
janwari 2013 mein, multiple sclerosis (ms) key ilaaj mein raletegravir key chikitsiya laabh kaa mulyankan karane key liye ack charan II pareekshan shuru kiya gayaa thaa. yeh dawa maanav antarjanit retrovirus (herves) aur sambhavatah appstein-baar virus key khilaf sakriya haye, joe relapsing-remitting ms key rogjanak mein sujhaae gaye hain.

