
lincomycin

lincomycin ack lincosamide antibiotic haye joe actinomycet "streptomyces linknensis" seey aataa haye. ack sambandhit yaugik, clindamycin, 7-hydroxy samooh koo chlorine paramanu key saath chirality key vyutkram key saath badalane key liye thynil chloride kaa upayog karke lincomycin seey praapt kiya jaataa haye. ise sitambar 1964 mein chikitsa upayog key liye jaari kiya gayaa thaa.
upayog karein.
halanki jivanurodhi spectrum aur macrolide key liye kaarravaai key tantra mein samaan, lincomycin actinomycets aur "mycoplasma" aur "plasmodium" kii kuchh prajaatiyon sahit anya jeevon key khilaf bhee prabhaavi haye.
haalaanki, isake pratikool prabhaavon aur vishaaktata key kaaran, aaj iska upayog shayed hii kabhi kiya jaataa haye aur yeh penicillin seey allergy vaale rogiyon yaa jahaan bacteria ney pratirodh vikasit kiya haye, key liye aarakshit haye.
naidaanik pharmacology.
600 milligram lincomycin kii ack khuraak key intramuscular prashaasan seey 60 minut mein 11.6 microgram/millie key ausat shikhar seeram star kaa utpaadan hotaa haye, aur sabse atisamvedansheel graam-positive jeevon key liye 17 ghante seey 20 ghante taka chikitsiya star banaae rakhta haye. iss khuraak key baad mootra visarjan 1.8% seey 24.8% (arthah 17.3%) taka hotaa haye.
600 milligram lincomycin kaa dou ghante kaa antahshira jalsek 15.9 microgram/millie key ausat shikhar seeram star koo praapt kartaa haye aur sabse atisamvedansheel graam-positive jeevon key liye 14 ghante key liye chikitsiya star pradaan kartaa haye. mootra visarjan 4.9% seey 30.3% taka hotaa haye (arthah 13.8%).
aaee. aim. yaa aaee. vee. prashaasan key baad javic ardh-jeevan 5.4 ±1.00 ghante haye. samanya gurde key kaary vaale rogiyon kii tulanaa mein, gurde key kaary mein gambhir haani vaale rogiyon mein lincomycin kaa seeram aadhaa jeevan lamba hoe sakata haye. asamanya yakrit kaary vaale rogiyon mein, seeram kaa aadhaa jeevan samanya yakrit kaary vaale rogiyon kii tulanaa mein doguna adhik hoe sakata haye. haemodialysis aur peritoneal dialysis seeram seey lincomycin koo hataane mein prabhaavi naheen hain.
ootak star key adhyayanon seey pataa chalata haye kii pitt visarjan kaa ack mahatvapurna maarg haye. shareer key adhikansh ootakon mein mahatvapurna star pradarshit kiye gaye hain. halanki lincomycin pramastishkameru drav (see. aiss. aff.) mein failata huaa dikhaai detaa haye, see. aiss. aff. mein lincomycin kaa star meningitis key upchaar key liye aparyaapt dikhaai detaa haye.
jaiv sanshleshan.
lincomycin ack antibiotic haye jise lincosamide varg key sadasya key roop mein vargeekrit kiya gayaa haye, jisamen aam taur parr ack ell-prolin emino acid vyutpann hotaa haye joe aathh-carbon eminotheo cheeni key saath amide samooh key madhyam seey judaa hotaa haye. dou ikaaiyaan 4-propyl-ell-prolin aur emino-octose, pratyek koo alag seey sanshleshit kiya jaataa haye, aur phir ell. aim. bee. dee. protein dwara sanghanit kiya jaataa haye, aur phir aage kii postcondensation pratikriyaon mein mycotheol, deacetylation, aur aiss-methylan koo alag karane seey anta mein lincomycin praapt hotaa haye.
lincomycin key amino acid bhaag kaa jaiv sanshleshan, tyrosine seey shuru hotaa haye joe ell. aim. bee. bee. 1, ell. aim. bee. bee. 2, ell. aim. bee. doubleu, ell. aim. bee. aeye aur ell. aim. bee. aiks. protein kii lagaatar kriya seey 4-propyl-ell.-prolin mein badal jaataa haye. 4-propyl-ell-prolin ell. aim. bee. see. dwara sakriya kiya jaataa haye aur ell. aim. bee. aine., ack dwi-karyatmak peptidile vaahak protein mein load kiya jaataa haye, aur ell. aim. bee. dee. dwara sanghanan key liye taiyar haye.
amino-octose bhaag key utpaadan key liye jaiv sanshleshit maarg lagbhag poori tarah seey spasht haye, halanki charanon key crum koo abhee bhee aage key shodh kii aavashyakta haye. fructose 6-phosphat yaa sedoheptulose-7-phosphat (ack see3 ikai pradaan karane vaalaa) key saath ribose 5-phosphat (see5) key ack transaldolage (ell. aim. bee. aar.) key madhyam seey sanghanan octose (see8) banaata haye. amino-octose ikai key nirmaan key liye isomization (ell. aim. bee. aine.), 1-phosphorylation (ell. aim. bee. pee.), 8-defosphorylation (ell. aim. bee. key.), sthiti 1 (ell. aim. bee. oh.) parr gwanosin diphosphate sanlagnak, 4-epimerisation (ell. aim. bee. aim.), 6-okseekaran (ell. aim. bee. ell.), emination (ell. aim. bee. aiss.), emine reduction (ell. aim. bee. aiss.) aur 8-reduction seey judey aage key parivartan kiye jaate hain. ell. aim. bee. tii. protein kaa vinimay ergotheonin dwara jee. dee. pee. aur 4-propyl-ell-prolin key saath sanghanan aur ell. aim. bee. dee. dwara utprerit hoe sakata haye. emino acid aur emino-octose key beach amide seey judaa utpaad joe ergotheonin seey bandha hotaa haye, taba ell. aim. bee. vee. kaa substrate hotaa haye, joe mycotheol dwara ergotheonin koo pratisthaapit kartaa haye. mycotheol bhaag koo phir ell. aim. bee. ee. dwara vibhajit kiya jaataa haye, aur utpaad koo ell. aim. bee. aaee. aich., ell. aim. bee. kyu., ell. aim. bee. jey., ell. aim. bee. aff. dwara aage sansaadhit kiya jaataa haye aur anta mein ell. aim. bee. jee. dwara sulfur methylated kiya jaataa haye, taaki lincomycin kaa kharch uthaaya jaa sakey.
samvedansheelta kaa varnakram.
lincomycin ack sankeern varnakram antibiotic haye joe graam-positive aur koshika-deewaar-rahit bacteria key khilaf gatividhi key saath haye jisamen "streptococcus", "staphylococcus" aur "mycoplasma" kii rogjanak prajaatiyan shamil hain. lincomycin kaa upayog una rogiyon mein gambhir jeevaanu sankraman key ilaaj key liye kiya jaataa haye joe penicillin antibiotic davaaon kaa upayog naheen curr sakate hain. lincomycin adhikansh graam-nakaratmak bacteria key khilaf kamjor gatividhi dikhaata haye. nimnalikhit kuchh rogjanak bacteria key liye samvedansheelta (mike) detta kaa pratinidhitva kartaa haih