
thymoglobulin

thymoglobulin (sainofi dwara nirmit) khargoshon seey praapt shuddh polyclonal antibody seey banaa ack maanav-virodhi thymocyte immunoglobulin haye. jabaki inn antibodies mein vibhinn prakaar kii vishishtataaen hoti hain, unaki pratiraksha daman kaa mukhya tantra tii koshikaon key kshay key madhyam seey hotaa haye. vartamaan mein thymoglobulin koo europe aur sanyukt raajya america mein naidaanik upayog key liye gurde key allographt asweekriti, graft-banaam kii roktham key liye anumodit kiya gayaa haye.-mezban roga, aur asthimajja viphalata seey judee sthitiyaan, jinamen applastic anaemia shamil haye aur isake atirikt off-label upayog hain.
antithymocyte globulin kaa itihas.
antithemocyte globulin (aeye. tii. jee.) koo mool roop seey antilymphocyte globulin (aeye. ell. jee.) kii vibhinn pareekshan kii gaee taiyari mein seey ack key roop mein vikasit kiya gayaa thaa joe vishesh roop seey thymus, yaa thymocytes key bheetar maanav lymphocytes key khilaf utpann hotaa haye. iss shodh kaa uddeshya kaafee hudd taka manushyon mein upayog key liye surakshit ack prabhaavi pratiraksha damankari agent kaa utpaadan karna thaa. 1899 mein matchnicoff dwara antilymphocyte seeram (aeye. ell. aiss.) aur lymphocyte kshay key beach ack kadee kii khoj key baad seey, vibhinn adhyayanon ney elg aur aeye. tii. jee. kii pratiraksha daman kshamata kaa pradarshan kiya haye. lymphocyte kshay mein isaki prabhavkarita kii pushti karane vaale anya prayogon ney vibhinn prakaar kii taiyari kaa pareekshan kiya, jisamen elg, joe maanav lymphocyte key khilaf utpaadit kiye gaye they, aur aeye. tii. jee. shamil they.
1960 key dashak mein kiye gaye kaee adhyayan, jinamen starzl aur anya dwara kiye gaye adhyayan shamil hain. aur maith aitt all., maanav gurda pratyaropan key turant baad rogiyon mein alpakaalik aur deerghakaalik gurde key kaary koo sanrakshit karane key liye lg key naidaanik upayog key liye ashajanak detta mein parinam. teevra kalam-banaam koo rokane mein ashwa-chakr kaa upayog bhee prabhaavi paaya gayaa.-rogiyon key allogenic asthi majja pratyaropan key baad mein mezban-roga. vibhinn sroton seey elg aur aeye. tii. jee. kii taiyari key saath prayog kiya gayaa, jisase khargosh seeram seey praapt aeye. tii. jee. kaa pareekshan kiya gayaa. thymoglobulin pahala vaanijyik khargosh-vyutpann atg thaa jise 1980 key dashak mein europe aur america mein pesh kiya gayaa thaa. ack pratirakshaatmak agent key roop mein isaki pradarshit prabhavkarita key kaaran, yeh aamtaur parr preran chikitsa aur anya sambandhit sthitiyon key upchaar key liye upayog kiya jaane vaalaa aeye. tii. jee. banaa huaa haye, jaise kii graft-banaam.-mezban roga aur applastic anaemia.
pratiraksha daman kaa tantra.
ack rait key roop mein, thymoglobulin mein polyclonal antibody hotey hain, joe monoclonal antibody key vipareet, bee aur tii lymphocyte, praakritik ghaatak koshika aur plasma koshika satah antigen sahit pratiraksha koshika satah protein kii ack badee vividhata koo lakshit karate hain. halanki, ack pratiraksha damankari agent key roop mein isaki prabhavkarita mukhya roop seey rakt pravaah mein maujood cd3 + tii koshikaon key teji seey prerit apoptosis key madhyam seey hoti haye. cumm sandrata (1 yuu. jee./millie. taka) parr bhee, ratji tii-koshika kshay kshamata abhee bhee achchi haye, lekin aeye. tii. jee. kii uchch sandrata bee. koshika aur aine. key. koshika kii kamee key saath-saath shaastriya poorak maarg key madhyam seey tii. lymphocytes key lysis koo prerit curr sakati haye. thymoglobulin ney cd25, gitter aur ctla-4 (urf cd152, pratiraksha jaanch key roop mein kaary kartaa haye, pratiraksha pratikriya koo cumm kartaa haye) sahit kaee niyaamak koshika markers "inn vitro" kii abhivyakti koo prerit karane kii kshamata kaa bhee pradarshan kiya haye. haal key shodhon ney sujhaav diyaa haye kii thymoglobulin tii-cell allergy mein bhee yogdan curr sakata haye, jisamen tii-koshikaaen nishkriya rahati hain, halanki iss baatchit kii pushti karane key liye aage key shodh kiye jaane chaahiye.
naidaanik anuprayog.
thymoglobulin kaa upayog aamtaur parr teevra asweekriti koo rokane aur ilaaj karane aur thhos anga pratyaropan (aiss. oh. tii.), vishesh roop seey gurde, yakrit, agnyashay aur hriday pratyaropan mein kalam key astitva koo badhaane key liye kiya jaataa haye. jaisa kii kaee adhyayanon ney naidaanik setting mein isaki prabhavkarita aur suraksha donon kaa pradarshan kiya haye, iska upayog thhos anga pratyaropan mein corticosteroids aur calcinurin avarodhak (see. aine. aaee. aiss.) jaise uchch jokhim vaale pratiraksha daman agents key anuprayog koo cumm karane key liye vibhinn nyuntam aaharon mein bhee kiya jaataa haye. kyonki corticosteroids aur see. aine. aaee. aiss. donon koo shareer mein sambhaavit roop seey deerghakaalik pratikool prabhaav paida karane key liye paaya gayaa haye, isaliye aiss. oh. tii. mein nyuntam upayog key saath yaa kissy bhee agent key upayog key binaa thymoglobulin kii prabhavkarita kii jaanch karane key liye kaee adhyayan kiye gaye hain. nishkarshon ney sanket diyaa haye kii akele thymoglobulin kaa upayog pratikool prabhaavon key jokhim koo cumm kartaa haye aur iss prakaar pratyaropan rogiyon key liye deerghakaalik parinamon mein sudhaar kartaa haye.
thymoglobulin graft-banaam koo rokane key liye bhee ack prabhaavi agent haye.-hematopoetic stame cell pratyaropan (aich. aiss. tii. tii.) praapt karane vaale rogiyon mein host roga. jee. vee. aich. dee. ack aisee sthiti haye jisamen kalam key bheetar pratiraksha koshikaaen mezban koshikaon parr hamla karati hain aur ootakon koo nuksan pahunchaati hain. ise safal aich. aiss. tii. key liye ack badee baadha maanaa jaataa haye. thymoglobulin kii tii-koshika kshayakaari gatividhi jee. vee. aich. dee. koo rokane mein upayogi saabit hui haye.
kaee adhyayanon ney sanket diyaa haye kii thymoglobulin una rogiyon key liye anya preran agents kii tulanaa mein anukool haye, jinamen pratyaropan key baad kii jatilataon key vikas kaa khatra badh jaataa haye, jaise kii bujurg rogi, baar-baar pratyaropan seey gujarane vaale rogi, aur aise rogi jinamen steroid yaa see. aine. aaee. aiss. key upayog koo cumm karane kii sifarish kii jaati haye.

