
upf0602

upf0602 manushyon mein ack protein haye joe gunasutra 4 open reeding frame 47 (see4orph47) jeane dwara encode kiya gayaa haye.
jeane.
c4orf47 jeane plus strand parr 4q35.1 parr sthit haye aur lambai mein 44,602 aadhar jode (185,405,227) mein faila huaa haye.. 185,449,828). jeane 12 exon aur 11 intron seey banaa haye.
dou anya jeenon key saath ativyaapi haye joe nakaratmak strand parr rahate hain. yeye jeane "yuu. aff. aim. 1 vishisht peptidase 2" (yuu. aff. aiss. pee. 2) aur "110 yukt kundalit-kundal kshetra" (see. see. dee. see. 110) hain.
see4orph47 jeane key liye ack aur upnaam lock441054 haye.
pratilekh.
pratilekh sanskaran 1, c4orf47 mrna kaa sabse lamba prayogaatmak roop seey maanya sanskaran haye aur yeh upf0602 protein isophorm 1 key liye kootbaddh haye. iss sanskaran mein pahale exon, ack avyavasthit kshetra aur agyaat kaary key kshetra key bheetar sthit ack upstream-frame stop coden key saath kull 8 exon hotey hain. aim. aar. aine. aeye. 1,333 nucleotide lamba hotaa haye aur 309 emino acid polypeptide key liye kootbaddh hotaa haye.
transcript sanskaran 2 5 'yuu. tii. aar. mein bhinn hotaa haye, ack vaikalpik anuvaad praarambh sthal kaa upayog kartaa haye, aur sanskaran 1 kii tulanaa mein 5' coding kshetra mein dou vaikalpik exon kaa abhaav haye. encoded protein isophorm (2) chhota haye aur protein isophorm 1 kii tulanaa mein ack alag aine-terminus haye. aim. aar. aine. aeye. 1,037 nucleotide lamba haye aur 183 emino acid polypeptide key liye encode kartaa haye.
c4orf47 mrna sabhi ootakon mein sarvavyaapi roop seey vyakt kiya jaataa haye, jisamen uchch abhivyakti coroid plexus, retina, phalopian tube aur testis key bheetar hoti haye.
protein.
upf0602 protein isophorm 1 kaa aanvik vajan 34.4kda haye aur anumaanit isoelectric bindu 9.64 paaee haye. isamen agyaat kaary kaa domen haye jise duff4586 key roop mein jaanaa jaataa haye. yeh domen pee. aff. aeye. aim. 15239 seey sambandhit haye joe protein superfamily see. ell. 21099 kaa ekmatra sadasya haye.
iss protein mein isake aakar key saapeksh buniyaadi amino acid kii ausat matra seey adhik matra hoti haye aur isamen dou dohrao vaale khand hotey hain.
sthaaniyakaran.
iss protein mein koee sanket peptide naheen hotaa haye aur koshika key bheetar koshika-dravya sookshm nalikaon, centrosome aur gair-gatishil siliya key liye sthaaniyakaran dikhaaya gayaa haye.
abhivyakti.
upf0602 sabhi ootakon mein sarvavyaapi roop seey vyakt kiya jaataa haye, jisamen fefadon, phalopian tubes aur vrishan key bheetar uchch abhivyakti hoti haye. fefde aur phalopian tubes mein ciliated koshikaon key bheetar sabse adhik protein kii prachurta dekhi jaati haye. vishesh roop seey siliya aur siliya exonum kii noke mein. vrishan key bheetar, protein kii prachurta lambe yaa dair seey shukranu mein sabse adhik hoti haye.
samroopata.
upf0602 protein mein koee paralog naheen haye. haalaanki, homolog adhikansh ciliated eukariotes key bheetar paae jaate hain. apvaadon mein kachhuon, salmonders aur paschimi bhaaratiya coelacanth key alawa anya lobe-finn machhliyon koo chhodkar sabhi sarisrip shamil hain. ack upf0602 protein homolog bhee kavak key ack varg, chitrideomycets key bheetar paaya jaataa haye. 
nimnalikhit talika visfot kaa upayog karate hue paae jaane vaale homolog key ack chhote seey chayan kaa pratinidhitva karati haye.
vikas.
fibrinogen alfa aur cytochrome see kii vikas darr kii tulanaa mein see4orph47 jeane apekshaakrit dheemi darr seey vikasit hoe rhaa haye. isase pataa chalata haye kii encoded protein key liye ack sanrakshit kaary haye. 
kaary.
koshika key bheetar iss protein key kaary koo vaigyaanik samudaay dwara achchi tarah seey samajha naheen jaataa haye, haalaanki saboot bataate hain kii yeh siliya aur flazella assembly seey sambandhit haye.
antahkriyaasheel protein.
uchch utpaadan pramaan upf0602 protein aur nucleophosmine (aine. pee. aim. 1) key saath-saath ubquitin-vishisht peptidase 9, vaaee-linked (yuu. aiss. pee. 9) key beach bhautik antahkriya kaa samarthan kartaa haye.
naidaanik mahatva.
yuu. aff. aiss. pee. 2 jeane overlapping see4orph47 key kshetron key bheetar ekal nucleotide bahuroopata (aiss. aine. pee. aiss.) koo beauk hip dysplasia, spondyloephimataphisal dysplasia, dee. rokko prakaar, microcephaly aur anya vikasatmak visangatiyon seey jodaa gayaa haye.

