
tii. aim. see. 1

transmembrane channel-jaise protein 1 ack protein haye jise manushyon mein "tii. aim. see. 1" jeane dwara kootbaddh kiya jaataa haye. tii. aim. see. 1 mein jhilli key endoplasmic paksh parr see aur aine donon terminals key saath chhah transmembrane domen hotey hain, saath hii saath domen 4 aur 5 key beach ack badaa loop hotaa haye. yeh topology kshanik receptor sambhaavit chainalon (tii. aar. pee. aiss.) key samaan haye, joe protein kaa ack parivaar haye joe tapman, swaad, dabaav aur drishti jaisi indriyon kii dhaarana mein shamil haye. tii. aim. see. 1 prasavottar mouse kokliya mein sthit haye, aur tii. aim. see. 1 aur tii. aim. see. 2 key liye nockout key parinamswarup shravan aur vestibular donon kii kamee (shravan haani aur santulan key mudde) hoti haye joe darshaata haye kii tii. aim. see. 1 shravan pargaman kaa ack aanvik hissa haye.
kaary.
iss jeane koo ack jeane parivaar kaa sadasya maanaa jaataa haye joe transmembrane protein koo kootbaddh karane key liye bhavishyavani kartaa haye. haal taka, iss jeane kaa vishisht kaary apekshaakrit agyaat thaa; yeh kewal coclear baal koshikaon key samanya kaary key liye aavashyak thaa. halanki, nae shodh seey pataa chalata haye kii tii. aim. see. 1 tip link protein protocaderine 15 aur caderine 23 key saath baatchit kartaa haye joe darshaata haye kii tii. aim. see. 2 key saath tii. aim. see. 1, baal koshika yaantrik paareshan key liye aavashyak protein hain. vishesh roop seey, tii. aim. see. 1 aur tii. aim. see. 2 channel kii dou chhidra banaane vaali upa-ikaaiyaan hoe sakati hain joe baal koshikaon mein tip link vikshepan kaa jawab detee hain.
coclear hayer cell function mein isake nihitarth aur hayer cell tip link key saath isaki baatchit key kaaran, receptor koo behtar dhang seey samajhane key liye tii. aim. see. 1 koo utparivartit aur herfer kiya jaa rhaa haye, saath hii saath baharepan key liye ack aanvik model kaa utpaadan bhee kiya jaa rhaa haye. jabaki shravan prasanskaran key kissy bhee charan mein badhirata utpann hoe sakati haye, dee. aff. aine. aeye. 36 (ack prakaar kaa pragatisheel shravan haani) aur dee. aff. aine. bee. 7/bee11 (janmajaat shravan haani) vishesh roop seey tii. aim. see. 1 utparivartan seey utpann honey key liye dikhaaya gayaa haye. dee. aff. aine. aeye. 36 ack pramukh missense utparivartan key parinam aur dee. aff. aine. bee. 7/bee11 ack aprabhaavi utparivartan key parinam hain. donon koo choohon mein pratiroopit kiya gayaa haye, jinhen kramshah beethovan model aur dn model key roop mein jaanaa jaataa haye. tii. aim. see. 1 jeane gunasutra 9kyu31-kyu21 parr sthit haye, aur dee. aff. aine. aeye. 36 seey judaa pramukh utparivartan emino acid 572 parr hotaa haye joe tii. aim. see. 1 key samagr kaary mein iss emino acid key mahatva kaa sujhaav detaa haye. abb jaba tii. aim. see. 1 koo tip link protein pee. see. dee. aich. 15 aur see. dee. aich. 23 key saath baatchit karane key liye dikhaaya gayaa haye, tou agala sawal yeh hoe sakata haye kii tii. aim. see. 1 tip link baatchit key liye emino acid 572 aavashyak haye yaa naheen.
shodhkartaon ney 2015 mein bataaya kii tii. aim. see. 1 jeane therapy seey ilaaj kiye gaye aanuvanshik roop seey badhir choohon ney apani kuchh sunavaai koo thheek curr liya.
naidaanik mahatva.
iss jeane mein utparivartan pragatisheel uttar-bhashai shravan haani, gair-syndromic badhirata aur gahan poorv-bhashai badhirata seey judey hue hain. tii. aim. see. 1 utparivartan anya lakshnon yaa asaamaanyataon seey judey naheen hain, jinhen gair-syndromic shravan haani key roop mein jaanaa jaataa haye aur yeh ingit kartaa haye kii tii. aim. see. 1 mukhya roop seey shravan samvedana mein kaary kartaa haye. isake alawa, jeane key aprabhaavi utparivartan key parinamswarup tii. aim. see. 1 kaary kii haani key saath-saath gahan badhirata donon hoti haye joe darshaati haye kii shravan sanketon key prasanskaran key liye tii. aim. see. 1 kaary aavashyak haye.