
benzimidazole opioid kii soochi

benzemidazole opioid, jise nitazine key roop mein bhee jaanaa jaataa haye, ack asamanya benzemidazole sanrachana key saath synthetic opioid kaa ack varg haye jise aksar opioid nae cycoactive padarthon (opioid nps) key roop mein sandarbhit kiya jaataa haye. pahali baar 1950 key dashak mein seeba pharmaceuticals dwara sambhaavit analgesic davaaon key roop mein sanshleshit, varg mein kaee padarthon kii pehchaan kii gaee haye, jinamen seey sabse achchha gyaat atonitazine haye. anya synthetic opioid kii tarah, benzemidazole opioid myu-opioid receptor koo baandhate hain aur morphin kii tulanaa mein kaee sou gunaa adhik shakti pradarshit curr sakate hain. jabaki iss varg mein kaee padarthon koo shodh mein anuprayog milaa haye, unakaa upayog kabhi bhee naidaanik chikitsa mein unake shwasan avasaad aur mrityu key gahare jokhim key kaaran naheen kiya gayaa haye, aur haal hii mein durupyog kii ubharati davaaon key roop mein pahachaana gayaa haye. isotonitazine kii pehchaan pahali baar avaidh davaaon key namoonon mein kii gaee thee, aur 2019 kii shuruat mein europe, kanada aur sanyukt raajya america mein opioid overdose seey honey vaali mauton mein fansaaya gayaa thaa. pahale seey gyaat nitazine analogue jaise kii metonitazine aur butonitazine, saath hii saath pahale patent naheen kiye gaye novell nitazine, taba seey forensic jaanch key dauran vishaakt namoonon mein khoje gaye hain.
dawa varg key sanrachana-gatividhi sambandh koo uchit seema taka khoja gayaa haye. ishtatam pratisthaapan pattern kaafee kaskar paribhaashit haye (i.ee. aine, amine nitrogen parr aine-diathyl, benzyl ring parr 4-ethoxy aur benzemidazole ring parr 5-nitro), lekin inmein seey kewal kuchh visheshtaon koo shamil karane vaale vyutpann abhee bhee shaktishali opioid hain. yadi benzyl samooh key alfa carbon parr ack methyl yaa carboxamide samooh jodaa jaataa haye, yaa benzyl koo 2-phenylathyl dwara pratisthaapit kiya jaataa haye, tou isi tarah kii gatividhi key yaugik praapt kiye jaate hain. saapeksh analgesic gatividhi moolya choohon parr parikshanon seey praapt hotey hain aur seedhe manushyon key liye extrapolate naheen kiye jaa sakate hain, halanki samaan samanya gatividhi rujhaan lagu hotey hain. 
2019 key ack prakaashan ney iss sambhavana koo dikhaaya haye kii benzemidazole varg kii pahale seey maani gaee badhyakari sthiti, ack ardh-kathor fentanil analogue key roop mein kaary karna galat hoe sakata haye. gyaat opioid receptor ligand key badey paimaane key vishleshan key aadhar parr ack template koo manual overlaying aur sanrekhan key madhyam seey banaaya gayaa thaa jisane receptor key bheetar kaee myu-vishisht kshetron kii pehchaan kii haye. iss vishleshan mein, yeh nott kiya gayaa haye kii atonitazine abb ack anya, alag myu-vishisht kshetra seey adhik nikatata seey mell khaata haye, joe fentanil varg key saath kewal ack chhote seey kshetra koo saajha kartaa haye.

