
haath 2

hriday aur tantrika shikhar vyutpann-abhivyakt protein 2 ack protein haye jise manushyon mein "haind 2" jeane dwara kootbaddh kiya jaataa haye.
kaary.
iss jeane dwara kootbaddh protein pratilekhan karakon key mool helix-loop-helix parivaar seey sambandhit haye. yeh jeane utpaad dou nikatata seey sambandhit parivaar key sadasyon mein seey ack haye, haath protein haath 1 aur haath 2, joe vikaasheel nilay kakshon mein asmamit roop seey vyakt kiye jaate hain aur hriday roopjanan mein ack aavashyak bhoomika nibhaate hain. ack poorak tareeke seey kaam karate hue, way daahine nilay aur mahadhamani kamaan dhamniyon key gathan mein kaary karate hain, joe unhein janmajaat hriday roga key madhyasth key roop mein nihit karate hain. isake alawa, yeh pratilekhan kaarak anga aur shaakhaon key vikas mein mahatvapurna bhoomika nibhaata haye. ack adhyayan mein, yeh paaya gayaa kii janmajaat hriday roga (chd) tetrology vaale rogiyon mein haind2 protein key ack missense utparivartan ney anya pramukh vikasatmak jeane jaise kii gaata4 aur nkx2.5 key saath haind2 kii baatchit mein kaafee kamee kaa anubhav kiya. haind2 utparivartan mein daahine nilay stenosis aur isake rogjanan key bhavishya key adhyayan key liye jeane honey kii kshamata haye. avian prajaatiyon mein, haath 2 koo aant key ootak key vikas mein vyakt kiya gayaa haye aur maanaa jaataa haye kii yeh aanton key neurons key gathan mein yogdan detaa haye.
choohon mein garbhavastha key liye ack uchit pratyaropan vatavaran kii sthaapana mein bhee haath 2 ack mahatvapurna bhoomika nibhaata haye. garbhashay key stromal ootak mein progesterone-nirbhar tantra dwara haath 2 kaa preran fibroblast vikas karakon (aff. jee. aff. aiss.) koo dabaa detaa haye joe anyatha astrogen utpaadan maargon koo uttejit karega aur bhroon pratyaropan koo baadhit karega.
homeobox jeane dee. ell. aiks. 5 aur dee. ell. aiks. 6 koo dabaakar choohon mein nichale jabade key gathan aur jeebh key roopjanan mein haath 2 ack bhoomika nibhaata haye.
antahkriyaaen.
haath 2 koo gaata 4, nkx2.5, ppp 2 aar 5 dee, fox 2 aeye key saath baatchit karane key liye dikhaaya gayaa haye., twist 1, aur twist 2.
naidaanik mahatva.
twist 1 aur twist 2 jeane key saath haath 2 kii baatchit uchit anga vikas key liye mahatvapurna haye. haal key saahitya seey pataa chalata haye kii haath 2 kii adhik matra key parinamswarup angon, chehare, hriday aur nichale cutty kasheruka mein kaee dosh hoe sakate hain. iss udaaharan mein, haath 2 jeane kii trisomy seedhe maanav janmajaat hriday roga kaa kaaran bunn sakati haye.
endometrial cancer key vikas koo badhaane key liye haind2 jeane hypermethyltion aur epigenetic silencing koo bhee shamil kiya gayaa haye. isake methylation koo dikhaane vaale badhate sakshya ney poorv-abhigamit endometrial ghaavon kii sambhaavanaon koo badhaa diyaa. haind2, vikaasheel hriday aur angon mein isake anya karyon key alawa, endometrial stroma mein dekhaa jaane vaalaa ack mahatvapurna pratilekhan kaarak paaya gayaa haye. vaastav mein, haath 2 jeane vaale choohon mein, jaise-jaise way badey hotey gaye, way poorv-roganu ghaav vikasit karate gaye, aur endometrial cancer key vikas mein isaki bhoomika key saboot pradaan karate hue. inn nishkarshon key kaaran endometrial cancer kaa jaldi pataa lagaane key liye haind2 ack sambhaavit ashajanak biomarker bunn gayaa haye aur iska upayog isake upchaar kii bhavishyavani karane key liye kiya jaa sakata haye.
haath kaa viniyaman.
haath 2 endothelial seey messenkimal sankraman (ee. aim. tii.) key vikas mein ack mahatvapurna pratilekhan kaarak haye joe atrioventricular nahar mein cardiac kushan key vikas kii anumati detaa haye joe mitral aur tricispid valve banaata haye. haind2 jeane niyaamak network mein kaee jeane hotey hain joe ee. aim. tii. prakriya mein kaary karate hain, vishesh roop seey snell1, jisaki abhivyakti khou jaati haye yadi haind2 kii kamee haye. choonki atria aur nilay key prithakkaran key liye haath 2 aavashyak haye, isaliye iss jeane mein ack utparivartan koo nilay septal doshon seey jodaa gayaa haye. haath 2 mein kamee kewal aanshik roop seey ghongha 1 dwara pratisthaapit kii jaati haye. haath 2 kii abhivyakti koo oopari lambe gair-coding rna dwara niyantrit kiya jaataa haye jise oopari haath (oopar) kahaa jaataa haye joe rna polymerase II key liye haath 2 koo transcribe karane key liye aavashyak haye. yadi oopar maujood naheen haye, tou haath 2 kii abhivyakti mein kamee aatee haye aur iss prakaar hriday vikas mein kamee aatee haye. jaba oopar koo baahar curr diyaa gayaa thaa, tou daahine nilay kaksh kaa vikas naheen huaa thaa aur haath 2 key baahar nikalane parr samaan phenotype thaa. isake alawa, haath 2 abhivyakti hriday key atria, nilay aur bahirvaah path mein anupasthit thee aur bratchial mehraabon aur anga kaliyon mein cumm hoe gaee thee.

