testosterone aur hriday pranali

testosterone aur hriday pranali purush harmon testosterone key hriday pranali parr padane vaale prabhaav hain. 
purushon mein pramukh androgen, testosterone, umr badhane kii prakriya key dauran kaafee cumm hoe gayaa haye. umr key saath seeram aur kull testosterone donon mein girawat koo purushon mein kaee rogon seey jodaa gayaa haye. vishesh roop seey, hriday viphalata aur ischemic hriday roga koo testosterone mein iss praakritik jaiv rasayanik girawat seey jodaa gayaa haye. isase pahale, purushon mein uchch hriday jokhim koo aanshik roop seey pranaaleegat testosterone key nakaratmak prabhaavon key liye jimmedaar thaharaaya gayaa haye, haalaanki, haal key shodh ney hriday roga key khilaf testosterone kii surakshaatmak prakriti koo ujagar kiya haye. purushon mein cumm testosterone hriday jokhim key rogjanan mein prabhaavshaali haye aur testosterone chikitsa key sambhaavit laabhon kaa parimaan aur karyapranali abhee taka poori tarah seey nirdhaarit naheen kii gaee haye.
pranaaleegat prabhaav.
cumm testosterone ack pro-atherosclerotic vatavaran key prachaar key madhyam seey coronary dhamani roga key liye ack badhe hue jokhim seey judaa huaa haye. kuchh shodhon ney coronary dhamniyon sahit shareer key kaee kshetron key bheetar ack vasodilator aur ack endothelium-marammat harmon key roop mein testosterone kii pehchaan kii haye. haal key shodh mein testosterone koo soojan cytokine jaise tumour necrosis factor alfa, alfa aur interleukin-6 key utpaadan koo cumm karane mein mahatvapurna key roop mein darshaaya gayaa haye, joe atherosclerotic profile mein prabhaavshaali hain. haalaanki yeh maanaa jaataa haye kii soojan cytokins mein kamee atherosclerotic profile mein kamee seey sambandhit haye, iss tantra key poorna spashteekaran key liye aage key shodh kii aavashyakta haye.
testosterone koo uchch collestroll aahar aur cumm ghanatva vaale lipoprotein jeane nockout vaale choohon donon mein mahadhamani collestroll key jamaav koo rokane key madhyam seey ack anty-atherosclerotic key roop mein bhee prabhaavi dikhaaya gayaa haye. cumm antarjaniya testosterone seey judey mahadhamani key bheetar vasaa kii jamaa koo androgen receptor seey swatantra honey key liye nirdhaarit kiya gayaa haye. halanki tantra koo abhee taka poori tarah seey nirdhaarit naheen kiya gayaa haye, aeromatase gatividhi aur astrogen receptor alfa kaa sakriyan cumm testosterone kii atherosclerotic profile visheshta key liye aanshik roop seey jimmedaar haye.
purushon mein systemic testosterone mein kamee hriday viphalata vaale purushon mein bhee darj kii gaee haye, jisase bimari kii gambhirta systemic testosterone key star mein kamee key samanupati haye. halanki kaarravaai kaa ack pratyaksh tantra poori tarah seey samajha naheen gayaa haye, kuchh shodh hriday viphalata key dushprabhavon koo aage badhaane key liye cumm testosterone kaa shreya dete hain, jaise kii vyayam kshamata mein kamee, maanspeshiyon key dravyamaan mein kamee, thakan/dyspania aur cachexia.
pratisthaapan chikitsa.
shaaririk testosterone purushon mein samanya karyakshamta key liye mahatvapurna haye. choohe key model mein shaaririk testosterone kaa deerghakaalik prashaasan collestroll key aich. dee. ell. hisse (anty-atherosclerotic collestroll) koo badhaakar atheroprotective dikhaaya gayaa haye. aich. dee. ell. ansh koo oopar uthaane mein testosterone kii laabhkaari kaarravaai kaa shreya edipose ootak mein aromatase gatividhi key madhyam seey 17-beeta astradiol mein isake roopaantaran aur astrogen alfa-receptors key baad key sakriyan koo diyaa jaa sakata haye; iss prakaar, adhik testosterone astrogen mein adhik roopaantaran kii or leey jaataa haye aur iss prakaar ack swasth lipid profile. yeh samajh kaee adhyayanon mein nirdhaarit kii gaee haye, halanki inn adhyayanon key parinam virodhabhasi hain.
pahale seey maujood hriday roga seey peedit purushon mein testosterone pratisthaapan chikitsa myocardial inforction key badhate jokhim seey sambandhit haye. isake alawa, haal key shodh ney testosterone pratisthaapan chikitsa koo purushon mein mauton mein vriddhi aur anya hriday sambandhi ghatnaaon seey jodaa haye joe coronary dhamani roga key itihas kaa dastavejikaran karate hain. yeh nirdhaarit karane key liye aage key shodh kii aavashyakta haye kii umr badhane vaale purushon mein testosterone pratisthaapan chikitsa hriday sambandhi ghatnaaon key jokhim aur/yaa laabh mein kiss hudd taka bhoomika nibhaati haye.
haalaanki, jaba alpakaalik aur madhyam avadhi mein hypogonadism vaale purushon koo diyaa jaataa haye, tou testosterone pratisthaapan chikitsa hriday sambandhi ghatnaaon (stroke aur dill key daure aur anya hriday rogon sahit) key jokhim koo naheen badhaati haye. iss sthiti key liye chikitsa kii deerghakaalik suraksha abhee taka gyaat naheen haye.

