tukade-adharit seesa khoj

tukade-adharit seesa khoj (aff. bee. ell. dee.) jise tukade-adharit dawa khoj (aff. bee. dee. dee.) key roop mein bhee jaanaa jaataa haye, dawa khoj prakriya key hisse key roop mein seesa yaugikon koo khojane key liye upayog kii jaane vaali ack vidhi haye. tukade chhote carbonic anu hotey hain joe aakar mein chhote aur aanvik vajan mein cumm hotey hain. yeh chhote rasayanik tukadon kii pehchaan karane parr adharit haye, joe kewal javic lakshya seey kamjor roop seey juda sakate hain, aur phir unhein badhaa sakate hain yaa unhein uchch aatmiyata key saath seesa kaa utpaadan karane key liye jodd sakate hain. aff. bee. ell. dee. kii tulanaa uchch-utpaadan jaanch (aich. tii. aiss.) seey kii jaa sakati haye. aich. tii. aiss. mein, lagbhag 500 dee. aeye. key aanvik bhaar vaale laakhon yaugikon vaale pustakalayon kii jaanch kii jaati haye, aur nanomolar binding affinity kii maang kii jaati haye. isake vipareet, aff. bee. ell. dee. key praarambhik charan mein, lagbhag 200 daa key aanvik bhaar vaale kuchh hazaar yaugikon vaale pustakalayon kii jaanch kii jaa sakati haye, aur millimolar affinity koo upayogi maanaa jaa sakata haye. aff. bee. ell. dee. ack takneek haye jiska upayog nae shaktishali avrodhakon kii khoj key liye anusandhaan mein kiya jaa rhaa haye. yeh paddhati kaee beemariyon key liye bahu-lakshit davaaon koo design karane mein madad curr sakati haye. bahu-lakshya avarodhak drishtikon kaee lakshyon key liye ack avarodhak koo design karane parr adharit haye. iss prakaar kii dawa kii rachana naveen aur prabhaavi upchaaron kii khoj key liye nae bahu-aushadhiya maarg kholati haye. alzheimer (aid) aur parkinsons jaise neurodegenerative roga bhee jatil atiopathology dikhaate hain. vigyaapan kii jatilata koo sambodhit karane key liye bahu-lakshit avarodhak adhik upayukt hain aur vigyaapan kii bahu-kaarak prakriti koo niyantrit karane key liye naee davaaen pradaan curr sakate hain, jisase isaki pragati koo rokaa jaa sakata haye. <ref naam = "doeeh 10.1002/cem.2556> </ref>
pustakalaya kaa design.
paanch key niyam key anuroop, yeh prastaavit kiya gayaa haye kii aadarsh tukadon koo 'teen key niyam' kaa paalan karna chaahiye (aanvik vajan <300, clogp <3, hydrogen bandhan daataon aur sweekaar karane vaalon kii sankhya pratyek <3 honey chaahiye aur ghoomane yogya bandhanon kii sankhya <3 honey chaahiye). choonki tukadon mein unake lakshyon key liye apekshaakrit cumm lagaav hotaa haye, isaliye unamen uchch jall ghulansheelata honey chaahiye taaki unhein uchch sandrata parr jancha jaa sakey.
pustakalaya kii jaanch aur parimaan.
tukade-adharit dawa kii khoj mein, tukadon kii cumm bandhan sambandhi aatmeeyataaen jaanch key liye mahatvapurna chunautiyon kaa saamana karati hain. iss samasya koo hull karane key liye kaee jaivbhautikiya takneekon kaa upayog kiya gayaa haye. vishesh roop seey, ligand-observe nuclear magnetic resonance (nmr) vidhiyaan jaise kii gradient spectroscopy (jall-logsy) key madhyam seey dekhe gaye jall-ligand, santripti hastaantaran antar spectroscopy (std-nmr), (std-nmr) nmr spectroscopy aur inter-ligand overhoser prabhaav (ilo) spectroscopy, protein-observe nmr vidhiyaan jaise kii kii heteronuclear ekal quantum coherance (hsqc) joe isotopical-labeled protein, satah key anunaad (spray), isothermal titermal calorimetry (itc) aur microscale thermophorasis (mst) kaa upayog niyamit roop seey ligand screening aur lakshya key liye protein bandhan key matratmak vibhajan key liye kiya jaataa haye. aadhunik aiks-ray chrystallography synchrotron beamline parr, protein-ligand jatil chrystal sanrachanaon key kaee sou detta sett 24 ghanton key bheetar praapt kiye jaa sakate hain. yeh takneek chrystallographic tukade kii screening koo sambhav banaati haye.ee. tukade kii jaanch key liye seedhe aiks-ray chrystallography kaa upayog.
ack baar jaba ack tukade (yaa tukadon key sanyojan) kii pehchaan hoe jaati haye, tou protein aiks-ray chrystallography kaa upayog protein-parisaron key sanrachanaatmak model praapt karane key liye kiya jaataa haye. iss tarah kii jaankaari kaa upayog uchch-aakarshan vaale protein ligand aur enzyme avrodhakon key liye carbonic sanshleshan kaa margadarshan karane key liye kiya jaa sakata haye.
paaramparik pustakalayon parr laabh.
paaramparik uchch aanvik vajan vaale rasayanik pustakalayon kii tulanaa mein cumm aanvik vajan vaale tukade adharit pustakalayon kii jaanch key kaee laabh hain. inmein shamil hainh

