
stau1

double-stranded aar. aine. aeye.-binding protein stoffen homolog 1 ack protein haye jise manushyon mein "stow 1" jeane dwara kootbaddh kiya jaataa haye.
stoffen dohare-fanse hue aar. aine. aeye. (dee. aiss. aar. aine. aeye.)-badhyakari protein key parivaar kaa ack sadasya haye joe vibhinn upkoshikiya dibbon aur/yaa angon mein aim. aar. aine. aeye. key parivahan aur/yaa sthaaniyakaran mein shamil haye. inn proteins kii visheshta kaee dee. aiss. aar. aine. aeye.-binding domen kii upasthiti haye joe double-stranded secondary sanrachanaon vaale aar. aine. aeye. koo baandhane key liye aavashyak hain. stoffen key maanav samroop mein, joe stow dwara kootbaddh haye, isake alawa isamen microtubul-sambandhit protein 1bee key samaan ack microtubul-binding domen hotaa haye, aur tubulin koo baandhata haye. stow jeane utpaad koo khurdare endoplasmic reticulum (aar. ee. aar.) key sahyog seey koshika dravya mein maujood dikhaaya gayaa haye, joe iss protein koo microtubul network key madhyam seey aim. aar. aine. aeye. key parivahan mein nihit kartaa haye, joe anuvaad sthal haye. stau jeane key vaikalpik vibhajan aur teen samroopon koo kootbaddh karane key parinamswarup paanch pratilekhan roopon kaa varnan kiya gayaa haye. inmein seey teen roop ack hii samroop koo kootbaddh karate hain, haalaanki, unake 5 'utter mein bhinn hotey hain.
stau1 tanaav granule seey judaa huaa haye.
sanrachana.
stoffen key dou orthologue, stoffen 1 (stow1) aur stoffen 2 (stow2) key alag-alag koshikiya kaary hain. stau1 kaee prakaar kii koshikaon aur ootakon mein vyakt kiya jaataa haye aur stau2 mastishk aur hriday mein vyakt kiya jaataa haye. stau1 kii abhivyakti koshikiya karyon key vyavadhaan aur neurodegenerative aur neuromuscular vikaaron aur cancer key pathophysiology seey judee hui haye. paripakva stau1 aim. aar. aine. aeye. paanch vaikalpik splies prakaron kaa utpaadan karate hain joe unake 5 'neutra kshetron mein alag-alag hotey hain. mukhya stau1 sanskaranon mein dohare-fanse hue rna-binding domen (dsrbd), ack microtubul-binding domen (tbd) aur ack stau1-swapping motif (smsm) hotey hain. 1-bandhan sthal (aiss. bee. aiss.) 1000 seey adhik pratilekhon key 3 'utter, 5' utter aur coding kshetron mein sthit hain.
viniyaman.
aar. aine. aeye. chayapachaya.
stau1 aar. aine. aeye. chayapachaya mein mahatvapurna bhoomika nibhaata haye aur mahatvapurna koshikiya karyon koo prabhaavit kartaa haye. stau1 lakshya aim. aar. aine. aeye. key 3 'yuu. tii. aar. mein sis-abhinay rupankanon yaa sthaaniyakaran sanketon koo pahachaantaa haye aur unake saath judataa haye. phir, motor protein dynine aur kinesine kii bharti kii jaati haye aur sakriya roop seey cytoskeletal network kaa upayog karke aim. aar. aine. aeye. koo upkoshikiya sthaanon parr leey jaaya jaataa haye. isase pataa chalata haye kii stau1 motor anuon aur aim. aar. aine. aeye. cargo koo jodane mein bhoomika nibhaata haye.
stau1 bhee aim. aar. aine. aeye. anuvaad mein ack bhoomika nibhaata haye. khurdara endoplasmic reticulum (aar. aar.) key saath stow1 sthaaniyakaran aim. aar. aine. aeye. koo anuvaad sthal taka leey jaane mein isaki bhoomika parr jore detaa haye. 
stau1 lakshya aim. aar. aine. aeye. key niyaamak rupankanon key liye seedhe aar. bee. pee. aiss. koo bandhkar aim. aar. aine. aeye. sthirata key viniyaman seey judaa huaa haye joe aim. aar. aine. aeye. sthirata koo badhaava detaa haye aur aim. aar. aine. aeye. anuvaad koo badhaata haye. udaaharan key liye, mouse myoblasts (see2see12 koshikaaen) mein, stau1 seedhe dv12 mrna key 3 'uter seey judataa haye, joe isaki sthirata koo badhaata haye aur koshika prasaar koo badhaava detaa haye. 
stau1 mrinaa kshay mein bhee bhoomika nibhaata haye. stau1-madhyasth aim. aar. aine. aeye. kshay (aiss. aim. dee.) ack aim. aar. aine. aeye. ksharan prakriya haye jisamen aiss. bee. aiss. key liye stau1 kaa seedha bandhan shamil haye, joe lakshya aim. aar. aine. aeye. key stop coden key neeche kii or sthit haye. ack baar jaba stau1 lakshya aim. aar. aine. aeye. seey bandha hotaa haye, tou stau1 aur aar. aine. aeye. helicase yuu. pee. aff. 1 key beach ack antahkriya hoti haye, joe isaki helicase gatividhi koo badhaati haye aur aiss. aim. dee. koo badhaava detee haye. yeh dikhaaya gayaa haye kii stau1, upf2 key liye badhyakari, upf1 kii tulanaa mein adhik sthir antahkriya haye, joe ingit kartaa haye kii stau1/upf2 parisar, aiss. aim. dee. kii site parr upf1 kii bharti key liye jimmedaar haye. isake alawa, maanav adp-ribosyllation kaarak 1 (arf1) 3 'neutra key bheetar aeye. aiss. bee. aiss. aiss. aiss. aiss. aiss. aiss. aiss. aiss. aiss. aiss. aiss. aiss. aiss. aiss. aiss. aiss. aiss. aiss. aiss. aiss. aiss. aiss. aiss. aim. dee. dwara aeye. aar. aff1 cytoplasmic aim. aar. aine. aeye. key star koo cumm kartaa haye.
koshika kaa vikas.
stau1 koshika chakr mein pramukh ghatakon key aim. aar. aine. aeye. anuvaad koo niyantrit kartaa haye, joe koshika vikas mein isaki bhoomika koo ingit kartaa haye. haal hii mein, koshika chakr aim. aar. aine. aeye. key 1-madhyasth post-transcriptional viniyaman ney gair-parivartit koshikaon kaa prasaar dikhaaya kyonki 30 koshika chakr niyaamak pratilekhon key abhivyakti star koo stau-1 ksheen koshikaon mein viniyamit kiya gayaa thaa. 
stau1 koo ee2aff1 mrna key 3 'neutra seey bhee baandhate hue dikhaaya gayaa thaa, jisane isake anuvaad mein ack bhoomika nibhai aur jee1/aiss sankraman koo badhaava diyaa. iss prakaar, stau1 abhivyakti tantrika jeane key uchit vibhajan aur abhivyakti seey judee haye.
koshika chakr key vibhinn charanon mein maanav parivartit koshika rekhaaon aich. see. tii. 116 aur yuu. too. oh. aiss. key prasaar mein stau1 star seey pataa chalaa kii stau1 protein kaa star aiss aur jee2 charanon key dauran badhata haye aur mitosis mein teji seey girata haye. stau1 aim. aar. aine. aeye. kaa star aparivartit rahata haye lekin stau1 protein anaphase-badhaava dene vaale jatil (aeye. pee. see.) ubquitin-proteosome pranali dwara avakramit hoe gaye they kyonki koshikaaen mitosis mein pravesh karati hain. 
jaba stau1 protein aeye. pee. see./see. adaptor protein see. dee. see. 20 aur see. dee. aich. 1 key saath antahkriya kartaa haye, tou mitotic koshikaon mein protesomal ksharan koo badhaava diyaa jaataa haye. inn udaharanon seey sanket milata haye kii stau1 kii apasthaaniya abhivyakti prasaar koo cumm karati haye aur pataa chalata haye kii mitosis parr stau1 key hanikarak prabhaavon kii roktham key liye stau1 staron kaa viniyaman aavashyak haye.
cancer mein bhoomika.
koshika dhruviyata.
vibhinn prakaar key koshika dhruviyata protein koo tumour suppressor yaa proto-oncogenes key roop mein vargeekrit kiya jaataa haye kyonki koshika dhruviyata key vyavadhaan koo cancer seey jodaa gayaa haye. stau1 koo alag-alag aanton kii upkala koshikaon mein epical poul mein asmamit roop seey vitarit kiya gayaa haye, joe samanya ootak vikas mein stau1-prerit koshika dhruviyata key mahatva koo prakat kartaa haye aur koshikaon aur angon parr stau1 apkraman key hanikarak prabhaav parr jore detaa haye. stau1 apniyaman cancer koshika key vikas aur pragati mein bhoomika nibha sakata haye. stau1 koo stame jaisi cancer koshikaon kii pluripotency aur vibhedan gunon key beach santulan banaae rakhane seey jodaa gayaa haye. iss hudd taka, stau1 cancer stame koshikaon key srot aur prakaar key aadhar parr tumour suppressor yaa oncogenic prabhaav pradarshit curr sakata haye. udaaharan key liye, mouse myoblast key vibhedan parr stau1 kii abhivyakti ney ack nakaratmak prabhaav dikhaaya haye, joe ingit kartaa haye kii stau1 cancer stame koshikaon mein myogenesis koo roque sakata haye aur maanspeshiyon seey sambandhit cancer koo badhaava dey sakata haye.
1-madhyasth mrinaa kshay.
stau1-madhyasth mrinaa kshay bhee cancer koshika prasaar key niyantran mein ack bhoomika nibhaata haye. tumour key vikas aur metastasis key avrodh key liye transcriptional factor retina aur purvakaaleen tantrika fold homobox 2 (aar. aeye. aiks. 2) transcript kaa aiss. aim. dee. aavashyak dikhaaya gayaa haye. isake alawa, aar. aeye. aiks. 2 pratilekhon key saath ack ribonucleoprotein parisar key saath stau1 kii antahkriya, mastishk seey praapt neurotrophic kaarak anticence (bee. dee. aine. aff.-aeye. aiss.) inkrana, aur aar. aine. aeye. helicase yuu. pee. aff. 1, aar. aeye. aiks. 2 aim. aar. aine. aeye. key aiss. aim. dee. koo trigger kartaa haye aur glioblastoma kii pragati koo rokta haye. ack anya adhyayan seey pataa chalaa haye kii jastaa-ungli protein 331 aim. aar. aine. aeye. kaa badhaa huaa 1-madhyasth ksharan glioma koshikaon key vikas seey judaa huaa haye aur seedhe tumour grade key saath sambandhit haye. isaliye, roga key charan aur isake pratyaksh aim. aar. aine. aeye. lakshyon key aadhar parr mastishk cancer key tumour ootakon kii tulanaa mein stau1 inn vitro model mein antar bhoomika nibha sakata haye. aiss. aim. dee. kaa uchit viniyaman uchch shreni key glioma mein tumour-rodhi prabhaav daal sakata haye.
koshikiya vibhedan.
gastric cancer koshika rekhaaon mein aiss. aim. dee. key sakht viniyaman seey isake upchaar aur purvanuman mein sudhaar hoe sakata haye. udaaharan key liye, gastric koshika rekhaaon (aiss. jee. see. 7901 aur bee. jee. see. 823) mein upregulated tinkr ell. aine. see. aar. aine. aeye., stau1, yuu. pee. aff. 1 aur key. ell. aff. 2 aim. aar. aine. aeye. key saath ack ribonucleoprotein complexes banaata haye, joe aiss. aim. dee. aur key. ell. aff. 2 pratilekhon koo badhaava detaa haye. aiss. jee. see. 7901 aur bee. jee. see. 823 mein aiss. jee. see. 7901 yaa key. ell. aff. 2 kii atee abhivyakti seey cycline-nirbhar kinnes (see. dee. key.) kii abhivyakti key star mein vriddhi hui aur koshika prasaar mein kamee aaee. 
stau1 translational regulation key madhyam seey cancer koshika key astitva koo niyantrit kartaa haye. udaaharan key liye, bhroon kii rabodomyosarcoma koshikaon (aar. dee.) mein, stau1 kii badhee hui abhivyakti koshika prasaar mein vriddhi seey judee hoti haye, joe bataati haye kii stau1 inn vitro kii aanuvanshik maunata cancer koshikaon key vikas koo cumm karati haye aur vivo mein tumour key gathan koo rokti haye. prostate cancer koshika line lncap mein stau1 kaa downeragulation apoptosis koo prerit kiye binaa inn koshikaon key prasaar koo rokta haye.
stau1 myogenic aim. aar. aine. aeye. kii sthirata aur anuvaad koo niyantrit kartaa haye, joe myoblast vibhedan koo nakaratmak roop seey prabhaavit kartaa haye. udaaharan key liye, see2see12 myoblast mein stau1 kii kamee koo myoglobin aur myogenine kii abhivyakti koo badhaane aur myogenesis key sahaj sakriyan koo badhaava dene key liye dikhaaya gayaa haye. 
maanav neuroblastoma koshika rekha mein, kuchh dendrite mein stau1 vaale ribonucleoprotein parisaron kaa sthaaniyakaran dendrite gathan aur aakriti vigyaan key liye aavashyak haye. isake alawa, yeh pataa chalaa kii dendrite key uchit vikas key liye aur aiss. aich. aiss. aaee. 5. vaaee koshikaon mein aiss. aich. aaee. 1 key sirna-madhyasth maun key liye aiss. aich. aiss. aaee. 5. vaaee koshikaon key vibhedan key dauran aiss. aich. aiss. aaee. 5. vaaee. koshikaon kii uchch abhivyakti kii aavashyakta hoti haye, joe aanshik roop seey koshika vibhedan koo avaruddh karati haye aur dendrite sangathan, ghanatva aur lambai koo badal detee haye. natijatan, samanya tantrika vikas, prasaar aur akshatantu vikas key liye 1-madhyasth vaikalpik vibhajan koo viniyamit karna mahatvapurna haye.
koshika pravaas.
zebrafish mein gamatogenesis key dauran adim roganu koshikaon (pee. jee. see.) key uchit pravaas key liye bhee stow 1 koo aavashyak dikhaaya gayaa haye. 1-samjhauta kiye gaye bhrunon mein, pee. jee. see. jeevit rahane mein whiffle rahey. stau1 kaee tantron key madhyam seey cancer koshika pravaas key sakaratmak aur nakaratmak viniyaman mein bhee bhoomika nibhaata haye. natijatan, stau1 koo cancer metastasis key avrodh key liye ack sambhaavit chikitsiya lakshya key roop mein saamane rakhaa gayaa haye. stow 1 nakaratmak roop seey aiss. aim. dee. key madhyam seey surpine 1 aur rubb 11-parivaar-paraspar kriya karane vaale protein 1 (rubb 11fip 1) key aim. aar. aine. aeye. ksharan koo badhaava dene key madhyam seey hella koshikaon key pravaas koo niyantrit kartaa haye. stau1 glioma koshika rekhaaon mein aiss. aim. dee. key madhyam seey dhaatu niyaamak pratilekhan kaarak 1 (aim. tii. aff. 1) aur vaaee. vaaee. 2 pratilekhan kaarak (vaaee. vaaee. 2) key ksharan key madhyam seey koshika pravaas aur aakraman koo avaruddh kartaa haye. isake vipareet, aar. dee. koshika rekhaaon mein, oonchaa stau1 koshika pravaas aur aakraman koo badhaava detaa haye aur stau1 kaa aanuvanshik maun koshika metastasis koo cumm kartaa haye aur cancer kii pragati koo rokta haye. prostate koshika rekhaaon mein, oonche steu1 ney fake signalling key madhyam seey pravaas aur aakraman mein vriddhi kii, joe ingit kartaa haye kii steu1 downregulation prostate cancer koshikaon kii gatishilata aur metastasis koo rokta haye. tantrika koshikaon mein stau1 key uchch star koo perk-chop maarg koo sakriya karke apoptosis koo badhaava dene aur neurodegeneration kii or leey jaane key liye dikhaaya gayaa haye. isake alawa, colorectal koshika rekhaaon aich. see. tii. 116, ell. aiss. 174tii, aur aich. tii.-29 mein, ell. aine. see. aar. aine. aiss. aich. jee. 5 dwara aiss. aim. dee. avrodh kaee aiss. aim. dee. lakshya aim. aar. aine. aeye. kii sthirata mein vriddhi key madhyam seey cancer koshika key astitva koo badhaava detaa haye.