
selexipag

uptravy brand naam key tahat becha jaane vaalaa selexipag, fuffusiya dhamani uchch raktchaap (piech) key upchaar key liye actellion dwara vikasit ack dawa haye. selexipag aur iska sakriya chayapachaya, adhiniyam-333679 (yaa aim. aar. ee.-269, mukt carboxylic acid), prostacycline receptor key agonist hain, joe fuffusiya parisancharan mein vasodilation kii or leey jaataa haye. ise munh seey liya jaataa haye yaa antahshira dwara prashaasit kiya jaataa haye.
yeh ack samanya dawa key roop mein upalabdh haye.
virodhabhas.
europe mein, yakrit enzyme sipe2see8 key majboot avrodhakon key saath selexipag kaa upayog, jaise kii gemphibrogyl, virodhabhasi haye kyonki yeh selexipag kii sandrata koo doguna aur isake sakriya chayapachaya koo 11 gunaa badhaata haye, jisase sambhaavit roop seey adhik pratikool prabhaav padate hain.
pratikool prabhaav.
selexipag key pratikool prabhaav fuffusiya dhamani uchch raktchaap key liye upayog kiye jaane vaale antahshira prostacycline key samaan hain. samanya dushprabhavon mein sirdard aur jabade kaa dard shamil haye. sealexipag lene vaale logon mein hyperthyroidism kaa khatra bhee badh gayaa haye.
pharmacology.
kaarravaai kaa tantra.
selexipag aur iska sakriya chayapachaya adhiniyam-33367 fefadon key ootak key prostacycline receptor parr kaary kartaa haye, jisamen baad vaalaa 37 gunaa adhik shaktishali hotaa haye. way prostacycline receptor key liye chayanaatmak hain. iss receptor key liye bandhan teen pramukh prabhaavon kii or leey jaataa haih dhamniyon key vadhate nasbandi, koshika prasaar mein kamee aur platelet ektrikaran kaa avrodh, yeye sabhi fuffusiya dhamani uchch raktchaap key upchaar mein fayademand hain.
pharmacokinetics.
selexipag jaldi seey aant seey avashoshit hoe jaataa haye aur aanton aur yakrit mein hydrolysed hocker carboxylsterases dwara 333679 kaary kartaa haye. poorna jaiv upalabdhata lagbhag 49 pratishat haye, joe uchch first-paas prabhaav key kaaran honey kii sambhavana haye. rakt plasma mein uchchatam sandrata ack seey teen ghante key baad selexipag key liye aur teen seey chaar ghante key baad sakriya chayapachaya key liye pahunch jaati haye. jaba parisancharan mein hotey hain, tou donon padarthon kaa lagbhag 99 pratishat plasma protein seey bandha hotaa haye, arthaat albumin aur alfa-1-acid glycoprotein key barabar matra mein.
yakrit enzyme sipe2see8 aur, kuchh hudd taka, sipe3aeye4, hydroxylate aur sakriya padaarth koo dlkylate karate hain, jisase yeh nishkriya hoe jaataa haye. isake alawa, adhiniyam-333679 koo yuu. jee. tii. 1aeye. 3 aur yuu. jee. tii. 2bee. 7 enzymon dwara glucuronize kiya jaataa haye. sealexipag kaa antim aadhaa jeevan 0.8 seey 2.5 ghante haye, sakriya chayapachaya kaa 6.2 seey 13.5 ghante haye.
itihas.
yuu.aiss. khaadya aur aushadhi prashaasan (aff. dee. aeye.) ney paah key liye selexipag anath aushadhi kaa darja pradaan kiya. ise 22 disambar 2015 koo aff. dee. aeye. dwara anumodit kiya gayaa thaa.
europe mein, dawa koo maee 2016 mein manjuri dee gaee thee.
samaaj aur sanskriti.
arthshastra.
chhoot seey pahale america mein dawa kii apekshit keemat prati rogi 160,000 dollar seey 170,000 dollar haye.