
dee1-dee2 dopamine receptor heteromer

dee1-dee2 dopamine receptor heteromer ack receptor heteromer haye jisamen dee1 aur dee2 protomer hotey hain.
sanrachana.
dee1 aur dee2 receptors mukhya roop seey pratyek receptor key koshika-dravya kshetron mein asatat amino acid key madhyam seey baatchit karate hain, jisamen transmembrane bhaagon kii koee bhagidari naheen hoti haye. dee2 receptor key antahkoshikiya loop 3 mein dou aasann arginine avashesh hotey hain, jabaki dee1 receptor kii carboxyl poonchh mein dou aasann glutamic acid avashesh hotey hain. donon receptors gwanidine bhaag aur carboxylic samooh key beach ack namak pull key madhyam seey ack heteromer complexes banaa sakate hain.
sanket pargaman.
dee1-dee2 receptor heteromer kaa sanket mool receptor monomers seey alag haye. isamen gq/11 yugman, phospholipase see sakriyan, innocitol trisphosphate receptor-samvedansheel bhandaron seey antahkoshikiya calcium release, kaimki sakriyan aur bdnf utpaadan shamil hain. isaki tulanaa mein, samroop dee5-dee2 receptor heteromer key sanket mein baahya koshikiya calcium kaa pravaah shamil haye.
shareer vigyaan.
dee1-dee2 receptor pramukh avasaad vaale vyaktiyon mein viniyamit hotaa haye, aur vishesh roop seey dee1-dee2 seey dee1 receptor kaa anupaat spasht roop seey heteromer kii or sthanantarit kiya jaataa haye. iss niyaman kaa mukabala karane seey avasaad key lakshan cumm hoe jaate hain. heteromer kaa vyavadhaan yaa tou seedhe ligand dwara koshika-dravya antarvirodh key saath baatchit karke, ligand dwara cumm seedhe joe baahya koshikiya bandhan sthal koo lakshit karate hain, yaa apratyaksh roop seey shaastriya avasaad-rodhi upchaar key downstream prabhaav key roop mein praapt kiya jaa sakata haye. ack adhyayan mein gs/ack yugman seey gq/11 sanket mein badalaav key sambandh mein nakaratmak parinam paae gaye; isaliye iss tarah kii gatishilata koo phospholipase see viniyaman key bajaay shivir-nirbhar cascade dwara madhyasthata kii jaa sakati haye.
purani tii. aich. see. ney dee1-dee2 heteromer-expressing neurons kii sankhya mein vriddhi kii, aur vayask monkey stratum mein vyaktigat neurons key bheetar heteromers kii sankhya mein vriddhi kii.

