
abiotexen

abotaxen ack mool 5/7/6 prakaar kii valay sanrachana key saath taxoid anuon kaa ack varg haye. yeh sanrachana paclitexel yaa dosetexcel jaise paaramparik taxoids mein paae jaane vaale 6/8/6 yaa 6/10/6-sadasya core ring seey bhinn hoti haye. ack samanya praakritik utpaad curr kaa mool carbon kankal (ee.jee.paclitexel, dosetexcel) mein 6-sadasyiya ack ring, 8-sadasyiya bee ring aur 6-sadasyiya see ring hoti haye, joe paaramparik side chain key saath sanyukt hoti haye. yeh side chain haye joe niyamit taxan key liye adhikansh gatividhi pradaan karati haye. abiotexen 3 parivartit valay sanrachanaon vaale yaugik hain, jahan valay aeye 5 sadasya haye, valay bee 7 sadasya haye aur valay see 6 sadasya haye, joe paaramparik paarshv shrinkhalaon key saath sanyukt haye.
taxan kii tarah, abiotexen yuu pedh (genus "taxus") dwara utpaadit dieterpane hain. yeye kaarak sookshm nalikaon koo prabhaavit karke cancer koshikaon key vikas aur pratikriti koo rokte hain. taxan atyadhik prabhaavi cancer-rodhi agent hain aur kaee thhos-tumour cancer key upchaar mein pahali aur doosari pankti kii chikitsa key roop mein upayog kiye jaate hain. 1998 mein paclitexel key fda anumodan key baad seey, baad key shodh ney bahu-dawa pratirodh aur kendriya tantrika tantra jaiv upalabdhata key muddon koo sambodhit karane key saath-saath dushprabhaav profile key sudhaar key liye nae aur behtar taxan key sanshleshan parr dhyaan kendrit kiya haye.
taxchinin aeye pahala praakritik roop seey honey vaalaa punarvyavasthit taxoid thaa jise 11 (15 → 1)-abiotexen key roop mein pahachaana gayaa thaa. taxchinin bee pahali baar pahachaana gayaa 11 (15 → 1)-ack oxyten ring key saath abiotexoid thaa. pahala praakritik taxoid, jisaki pehchaan 11 (15 → 1)-abiotexen ring key roop mein kii gaee thee, bravifoliol thaa. tii. pee. aaee. 287 (poorv mein aark-100), ack 11 (15-1)-abiotexen joe 2010 mein naidaanik vikas key charan mein thaa, ney bahu-dawa pratirodhi tumour prakaron mein shaktishali gatividhi kaa pradarshan kiya haye, jisamen taxen-pratirodhi tumour shamil hain, saath hii saath rakt-mastishk baadha koo paar karane mein prabhavkarita bhee shamil haye.

