
idh3aeye

isocitrate dehydrogenase [nad] subunit alfa, mitochondrial (idh3α) ack enzyme haye jise manushyon mein "idh3aeye" jeane dwara encode kiya jaataa haye.
isocitrate dehydrogenase (aaee. dee. aich. aiss.) isocitrate key oxidative decarboxylation koo 2-oxogluterate mein utprerit karate hain. yeye enzyme dou alag-alag upvargon seey sambandhit hain, jinamen seey ack electron sweekaarak key roop mein nad (+) kaa upayog kartaa haye aur doosara nadp (+). paanch isocitrate dehydrogenase kii soochana dee gaee haih teen nad (+)-nirbhar isocitrate dehydrogenase, joe mitochondrial matricks mein sthaaniya hotey hain, aur dou nadp (+)-nirbhar isocitrate dehydrogenase, jinamen seey ack mitochondrial haye aur doosara mukhya roop seey cytosolic haye. nad (+)-nirbhar isocitrate dehydrogenase tricarboxylic acid chakr key allosteric roop seey viniyamit darr-seemit karane vaale charan koo utprerit karate hain. pratyek samasthaanik ack visham-samasthaanik haye joe dou alfa upa-ikaaiyon, ack beeta upa-ikai aur ack gaama upa-ikai seey banaa haye. iss jeane dwara kootbaddh protein, naad (+)-nirbhar isocitrate dehydrogenase key ack isozyme kaa alfa upghatak haye. [refsec, julaai 2008 dwara pradaan kiya gayaa]
sanrachana.
aaee. dee. aich. 3 teen isocytrate dehydrogenase isozymes mein seey ack haye, anya dou aaee. dee. aich. 1 aur aaee. dee. aich. 2 hain, aur paanch isocytrate dehydrogenase jeane mein seey ack dwara encode kiye gaye hain, joe "aaee. dee. aich. 1", "aaee. dee. aich. 2", "aaee. dee. aich. 3aeye", "aaee. dee. aich. 3bee", aur "aaee. dee. aich. 3jee" hain. jeane "idh3aeye", "idh3bee", aur "idh3jee" idh3 key upa-ikaaiyon koo kootbaddh karate hain, joe dou 37-kda upa-ikaaiyon (idh3α), ack 39-kda beeta upa-ikai (idh3β), aur ack 39-kda upa-ikai (idh3γ) seey banaa ack heterotetrammer haye, pratyek alag-alag samvidyut binduon key saath. unake amino acid anukramon key sanrekhan seey pataa chalata haye kii idh3α aur idh3β key beach pehchaan ~40%, idh3α aur idh3γ key beach pehchaan, aur idh3β aur idh3γ key beach 53 pratishat kii aur bhee karibi pehchaan, kull milakar 34 pratishat pehchaan aur teenon upa-ikai prakaron mein 23 pratishat samaantaa key liye. vishesh roop seey, idh3aeye mein aarg88 idh3 utprerak gatividhi key liye aavashyak haye, jabaki idh3beee mein samatulya aarg99 aur idh3gm mein aarg97 kaafee hudd taka adp aur nad dwara enzyme key allosteric viniyaman mein shamil hain. iss prakaar, yeh sambhav haye kii yeye upa-ikaaiyaan ack samanya paitrik jeane key jeane duplication seey utpann huin, aur mool utprerak aarg avashesh koo β-aur γ-upa-ikaaiyon mein allosteric karyon key liye anukoolit kiya gayaa thaa. isi tarah, idh3aeye mein asp181 utpreran key liye aavashyak haye, jabaki idh3beee mein asp192 aur idh3gm mein asp190 nad-aur mn2 +-binding koo badhaate hain. choonki aaee. dee. aich. 3 dwara utprerit oxidative decarboxylation key liye nad, mn2 + aur substrate isocitrate key bandhan kii aavashyakta hoti haye, isaliye teenon upa-ikaaiyaan utprerak pratikriya mein bhaag letee hain. isake alawa, suggar key hriday mein enzyme key adhyayan seey pataa chalata haye kii αβ aur αγ diamer isake pratyek ligand key liye dou bandhan sthalon kaa gathan karate hain, jisamen ack aaee. dee. aich. 3 tetramer mein isocitrate, aim. aine. 2 + aur nad shamil hain.
kaary.
ack isocitrate dehydrogenase key roop mein, aaee. dee. aich. 3 glucose chayapachaya mein tii. see. aeye. chakr key hisse key roop mein isocitrate key aparivartaniya oxidative decarboxylation koo α-catogluterate (α-kigra) aur see. oh. 2 kii upaj key liye utprerit kartaa haye. yeh kadam nad + seey nadh kii sahavarti kamee key liye bhee anumati detaa haye, jiska upayog taba electron parivahan shrinkhala key madhyam seey aeye. tii. pee. utpann karane key liye kiya jaataa haye. vishesh roop seey, idh3 apane electron sweekaarak key roop mein nad + parr nirbhar kartaa haye, jaisa kii idh1 aur idh2 jaise nadp + key vipareet. idh3 gatividhi koshika kii oorjaa aavashyaktaon dwara niyantrit kii jaati haih jaba koshika koo oorjaa kii aavashyakta hoti haye, idh3 adp dwara sakriya kiya jaataa haye; aur jaba oorjaa kii aavashyakta naheen hoti haye, tou idh3 atp aur nadh dwara baadhit hotaa haye. yeh allosteric viniyaman aaee. dee. aich. 3 koo tii. see. aeye. chakr mein darr-seemit karane vaale charan key roop mein kaary karane kii anumati detaa haye. koshikaon key bheetar, aaee. dee. aich. 3 aur isaki upa-ikaaiyon koo mitochondria mein sthaaniyakrit honey key liye dekhaa gayaa haye.
naidaanik mahatva.
idh3α abhivyakti koo cancer seey jodaa gayaa haye, jisamen kaee cancer koshika rekhaaon mein uchch besal abhivyakti aur cancer rogiyon mein kharaab purvanuman kaa sanket dene vaali abhivyakti mein vriddhi hui haye. aaee. dee. aich. 3. aeye. koo α-kilogram key niyaamak key roop mein tumour key vikas koo badhaava dene key liye prastaavit kiya gayaa haye, joe baad mein aich. aaee. aff.-1 koo niyantrit kartaa haye. aich. aaee. aff.-1 koo kaafee hudd taka cancer koshikaon mein oxidative phosphorylation seey aerobic glycolysis mein glucose chayapachaya koo sthanantarit karane key liye jaanaa jaataa haye (warberg prabhaav). isake alawa, aaee. dee. aich. 3. aeye. gatividhi angiogenesis aur chayapachaya punahprograaming kii or leey jaati haye taaki nirantar koshika vikas key liye aavashyak poshak tatva pradaan kiye jaa sakein. iss beach, tumour key vikas mein baadha daalane key liye aaee. dee. aich. 3. aeye. koo shaant karate hue dekhaa jaataa haye. iss prakaar, ee. dee. aich. 3. aeye. cancer key ilaaj mein ack ashajanak chikitsiya lakshya saabit hoe sakata haye.
aaee. dee. aich. 3. aeye. bhee manorog vikaaron mein shamil haye. vishesh roop seey, dwidhruvi vikaar, pramukh avasaadgrastata vikaar aur schizophrenia key liye pramastishk mein idh3α abhivyakti kaafee cumm dekhi jaati haye. asamanya aaee. dee. aich. 3. aeye. star mitochondrial kaary koo baadhit curr sakate hain aur inn vikaaron key rogjanan mein yogdan curr sakate hain.
iss jeane mein utparivartan autosomal recessive retinitis pigmentosa seey judey hue hain.

