
reboxetin

reboxetin, jise brand naam adronex key tahat becha jaataa haye, norpinephrine reptech inhibitor (aine. aar. aaee.) varg kii ack dawa haye, jise pramukh avasaad key upchaar mein upayog key liye pee. fizer dwara avasaadarodhi key roop mein vipanan kiya jaataa haye, halanki iska upayog panic disorder aur attension deficit hyperactivity disorder (aeye. dee. aich. dee.) key liye bhee kiya gayaa haye. ise duniya bhar key kaee deshon mein upayog key liye anumodit kiya gayaa haye, lekin sanyukt raajya america mein upayog key liye anumodit naheen kiya gayaa haye. haalaanki ack avasaadarodhi key roop mein isaki prabhavsheelta koo kaee prakaashit reports mein chunauti dee gaee haye, lekin isaki lokpriyata mein vriddhi jaari haye.
chikitsa upayog.
pramukh avasaadgrastata vikaar.
iss baat parr bahut bahas hui haye kii kyaa avasaad key ilaaj mein reboxetin placebo kii tulanaa mein adhik prabhaavi haye. 12 doosari peedhi key avasaadarodhi davaaon key 2009 key metaa-vishleshan key anusaar, reboxetin placebo kii tulanaa mein adhik prabhaavi naheen thaa, aur ekdhruviya pramukh avasaad vaale vayaskon key teevra-charan key ilaaj mein anya davaaon kii tulanaa mein "kaafee cumm" prabhaavi aur cumm sweekarya thaa.
british aim. aar. aeye. ney sitambar 2011 mein kahaa kii adhyayan kii kaee seemaaen theen, aur "kull milakar reboxetin key liye laabhon aur jokhimon kaa santulan isake adhikrit sanket mein sakaratmak banaa huaa haye."upalabdh prabhavkarita aur suraksha detta kii britten aur europe-vyaapi sameeksha ney pushti kii haye kii reboxetin koo apane adhikrit sanket mein placebo parr laabh haye. gambhir yaa bahut gambhir avasaad vaale rogiyon mein prabhavkarita spasht roop seey dikhaai gaee thee.
equig dwara ack vyavasthit sameeksha aur metaa-vishleshan key anusaar, aprakaashit detta sahit, reboxetin parr prakaashit detta ney reboxetin banaam placebo key laabh koo 115% taka aur reboxetin banaam ssris key laabh koo 23 pratishat taka cumm karke aanka, aur nuksan koo bhee cumm karke aanka, yeh nishkarsh nikaalate hue kii reboxetin ack aprabhaavi aur sambhaavit roop seey hanikarak avasaadarodhi thaa. adhyayan seey yeh bhee pataa chalaa kii reboxetin key parikshanon mein bhaag lene vaale rogiyon key lagbhag teen chauthai detta koo pfizer dwara prakaashit naheen kiya gayaa thaa.
21 avasaadarodhi davaaon kii prabhavkarita aur sweekaryata kii tulanaa karate hue 2018 kii ack vyavasthit sameeksha aur network metaa-vishleshan ney nishkarsh nikala kii reboxetin placebo kii tulanaa mein adhik prabhaavi thaa lekin pareekshan kiye gaye anya avasaadarodhi davaaon kii tulanaa mein kaafee cumm prabhaavi thaa.
ghabarahat vikaar.
ack yaadrichhik double-blind placebo-niyantrit pareekshan reboxetin mein panic disorder key lakshnon mein kaafee sudhaar huaa. ack anya yaadrichhik niyantrit pareekshan jisamen peroxetin kii tulanaa reboxetin seey kii gaee, mein paaya gayaa kii peroxetin ney panic disorder key upchaar key roop mein reboxetin seey kaafee adhik pradarshan kiya. aiss. aiss. aar. aaee.-pratirodhi ghabarahat vikaar mein reboxetin kii prabhavkarita kii jaanch karane vaale ack khule-label pareekshan koo khojane key bavjood, reboxetin upchaar seey mahatvapurna laabh pradarshit kiya.
dhyaan kii kamee atee sakriyata vikaar.
kaee naidaanik parikshanon ney alpakaalik aur deerghakaalik donon mein aur bachchon/kishoron aur vayaskon donon mein dhyaan kamee atee sakriyata vikaar (aeye. dee. aich. dee.) key upchaar mein reboxetin kii prabhavkarita key liye samarthan pradaan kiya haye.
anya upayog.
ack cases shrinkhala aur open-label pilot adhyayan ney bulimiya nervosa key ilaaj mein reboxetin kii prabhavkarita kaa pradarshan kiya. reboxetin chikitsa-pratirodhi baal chikitsa nishaachar aneurasis key ilaaj mein bhee prabhaavi hoe sakata haye. ack praayogik adhyayan ney narcolepsy key upchaar mein reboxetin kii prabhavkarita kaa pradarshan kiya. vyaktigat parikshanon aur metaa-vishleshan seey pataa chalata haye kii reboxetin manovikriti-prerit vajan vriddhi koo cumm curr sakata haye aur avasaad parr laabh key kuchh pramaan hain, aur sambhavatah schizophrenia key anya lakshan jaba manovikriti-rodhi upchaar mein jode jaate hain.
virodhabhas.
reboxetin sankeern konn glucoma, hriday roga, mirgi, dwidhruvi vikaar, mootra pratidhaaran, prostatic hypertrophy, reboxetin yaa isake kissy bhee uttejak key prati atisamvedansheel mein pratikool haye.
pratikool prabhaav.
bahut aam (> 10 pratishat ghatanaaen) pratikool prabhaavon mein anidra, chakkar aanaa, munh sookhana, kabj, matali aur atyadhik pasina aanaa shamil hain.
samanya (1-10%) pratikool prabhaavon mein bhookh naa lagana, uttejana, chinta, sirdard, bechaini, jhunjhuni, swaad kii vikrit bhavna, paas yaa door dekhane mein kathinaaee (samaayojan key saath samasyaaen), tej dill kii dhadkan, dill kii dhadkan, rakt vaahikaon mein aaraam jisase nimn raktchaap, uchch raktchaap, ulti, chakatte, mootrashay key adhure khaali honey kii anubhooti, mootra path kaa sankraman, dardanaak yaa kathin peshab, mootra pratidhaaran, stambhan dosh, skhalan dard yaa deree, aur thhand lagana shamil hain.
2009 key ack metaa-vishleshan mein paaya gayaa kii vishleshan kii tulanaa mein anya 11 doosari peedhi key avasaadarodhi davaaon kii tulanaa mein reboxetin kaafee cumm achchi tarah seey sahan kiya gayaa thaa.
overdose.
adhik matra mein reboxetin koo apekshaakrit cumm jokhim vaalaa avasaadarodhi maanaa jaataa haye. lakshan iss prakaar hainh
antahkriyaaen.
sipe3aeye4 parr apani nirbharta key kaaran, reboxetin "oh"-desathylation koo papaverine aur catoconazole dwara spasht roop seey baadhit kiya jaataa haye. yeh sipe2dee6 aur sipe3aeye4 koo kamjor roop seey rokta haye. reboxetin pee-glycoprotein kaa ack madhyavarti-star kaa avarodhak haye, joe ise cyclosporin, tachrolimus, peroxetin, certraline, quinidine, fluxettin, fluvoxamine key saath baatchit karane kii kshamata detaa haye.
pharmacology.
pharmacodynamics.
reboxetin ack kaafee chayanaatmak norpinephrine reptech avarodhak (aine. aar. aaee.) haye, jisamen serotonin transporter (cert) parr norpinephrine transporter (nett) key liye lagbhag 20 gunaa chayanaatmaktaa haye. iss chayanaatmaktaa key bavjood, reboxetin chikitsiya khuraak parr serotonin key punah grahan koo thodaa rokta haye. yeh dopamine transporter (dee. aeye. tii.) key saath baatchit yaa avrodh naheen kartaa haye.
reboxetin koo mastishk aur hriday donon key gurks koo rokane key liye paaya gayaa haye, ack visheshta joe yeh aine. aar. aaee. atmoxetin key saath saajha karati haye.
pharmacokinetics.
reboxetin key ("r", "r")-(-) aur ("s", "s")-(+)-anantiomers donon mukhya roop seey sipe3aeye4 isoenzyme dwara chayapachaya kiye jaate hain.
reboxetin kaa praathamik chayapachaya "oh"-decithyleraboxatine haye, aur teen chhote chayapachaya bhee hain-phenol aeye, phenol bee, aur yuke1, phenol bee sabse chhota haye.
rasayan vigyaan.
reboxetin mein dou kieral kendra hotey hain. iss prakaar, chaar stereoisomers maujood hoe sakate hain, ("r", "r")-, ("s", "s")-, ("r", "s")-, aur ("s", "r")-isomers. reboxetin kaa sakriya ghatak dou ananciomers, ("r", "r")-(-)-aur ("s", "s")-(+)-isomer kaa ack resemic mishran haye.
itihas.
reboxetin kii khoj formitalia-carlo erba mein kii gaee thee aur pahali baar 1984 mein prakaashit kiya gayaa thaa; formitalia ney pahala naidaanik adhyayan kiya thaa. formitalia kaa adhigrahan 1993 mein pharmacy dwara kiya gayaa thaa, aur badale mein pharmacy kaa adhigrahan 2003 mein pfizer dwara kiya gayaa thaa.
ise pahali baar 1997 mein europe mein anumodit kiya gayaa thaa aur 1999 mein fda dwara asthaayi roop seey anumodit kiya gayaa thaa. 2001 mein fda ney naidaanik parikshanon key aadhar parr pfizer koo ack "apraapya" patra jaari kiya thaa jisaki fda koo praarambhik anumodan patra jaari karane key samay aavashyakta thee.
2010 mein, german institute forr quality aind efficiency inn health cayer (aaee. key. ee. aich. see.) ney teevra avasaad mein reboxetin key liye naidaanik pareekshan detta key metaa-vishleshan key parinam prakaashit kiye, jisamen lagbhag 3,000 vishayon parr detta shamil thaa jinhen pee. aff. aaee. aar. ney kabhi prakaashit naheen kiya thaa, lekin ullekh kiya thaa; aaee. key. ee. aich. see. ney pee. aff. aaee. aar. key prakashanon aur reboxetin anumodanon key madhyam seey jaanch kii thee aur nirdhaarit kiya thaa kii yeh detta prakaashan record seey gayab thaa. poorna detta sett key vishleshan seey ack parinam nikla kii reboxetin placebo kii tulanaa mein adhik prabhaavi naheen thaa, lekin placebo kii tulanaa mein adhik dushprabhaav thaa aur fluxettin kii tulanaa mein adhik thaa; pepper ney pfizer kii vyaapak aur teekhi aalochana kii, aur sabhi naidaanik pareekshan detta key prakaashan key liye majboot ahwan kiya.
samaaj aur sanskriti.
brand naam.
adronex pratyek angreji bhashi desh mein reboxetin kaa brand naam haye jisane ise naidaanik upayog key liye manjuri dee haye. brand naamon mein shamil hain (jahaan  ± ack utpaad koo darshaata haye jiska abb vipanan naheen kiya jaataa haye):
sandarbh.
HTTPS:// W.cambridge.org/core/journal/cns-spectrum/lekh/prescribers-guide-too-classic-maao-inhibitors-fenalzine-tranilcypromine-isocarboxazid-forr-treatment resistant-depression/29c70fd3da65e23a024d5e05c4369983

