
danheiser benzanulation

danheiser benzanulation ack rasayanik pratikriya haye jiska upayog carbonic rasayan vigyaan mein ack hii charan mein atyadhik pratisthaapit phenol utpann karane key liye kiya jaataa haye. iska naam rick ell key naam parr rakhaa gayaa haye. danheiser jisane pratikriya vikasit kii.
vaarshiki.
ack vaarshikaran koo ack yaa adhik chakreeya agraduton key parivartan key roop mein paribhaashit kiya jaataa haye jisake parinamswarup dou nae utpann bandhanon key madhyam seey ack naee valay kaa sanlayan hotaa haye. inn ranneetiyon kaa upayog ack hii charan mein chakreeya agraduton seey sugandhit pranaliyon koo banaane key liye kiya jaa sakata haye, jisamen pahale seey hii kaee pratisthaapan hain. ack samanya synthetic annulation pratikriya robbinson annulation haye. yeh chhah-sadasyiya valay banaane aur polycyclic yaugikon koo utpann karane key liye ack upayogi pratikriya haye. yeh michael jodd aur aldol sanghanan pratikriya kaa sanyojan haye.
pratikriya vikas.
polysbstituted benzene koo mool roop seey sugandhit agraduton parr pratisthaapan pratikriyaon dwara sanshleshit kiya gayaa thaa. haalaanki, inn pratikriyaon mein cumm regioselectivity hoe sakati haye aur adhik pratisthaapan key liye pravan hoe sakati haye. nirdeshit "ortho" dhatukaran key liye poorvavartiyon kii aavashyakta hoti haye joe aksar dhaatu abhikarmakon key liye asthir hotey hain. yeye donon kritrim maarg kull sanshleshan mein samasyaaen paida karate hain. 1984 mein rick danheiser dwara inn kamiyon koo door karane key liye ack naee kritrim ranneeti vikasit kii gaee thee.
pratikriya.
danheiser benzanulation ack regiocontrold phenol annulation haye. yeh vaarshiki ack charan mein ack sugandhit valay banaane key liye ack kushal maarg pradaan karati haye. yeh atyadhik pratisthaapit sugandhit yaugikon, vishesh roop seey phenol yaa resourcinol (yojana 1) kaa utpaadan karane key liye heterosubstituted acetylene key saath ack pratisthaapit cyclobutanone kaa ack thermal sanyojan haye. yeh benzanulation pratikriya pahale seey aprachalit sugandhit pratisthaapan pattern banaati haye. iss vidhi kaa upayog karke vibhinn prakaar key pratisthaapit sugandhit valay taiyar kiye jaa sakate hain jinamen shamil hainh phenol, nafthalene, benzophurance, benzotheophene, indol aur carbazole.
sanshodhit danheiser benzanulation polycyclic sugandhit aur visham-aeromatic pranaliyon key sanshleshan kii anumati detaa haye. isamen napthalene, benzofuran aur indol bhee shamil hain. yeh doosari peedhi kaa sugandhit annelation acetylene key ghol aur dichloroethane mein vinail yaa eril α-diazo keaton key vikiran dwara praapt kiya jaataa haye. yeh pratikriya ack eril yaa vinailketin utpann karane key liye ack diazocatone key photochemical wolf punarvyavastha kaa upayog karati haye. inn kettin madhyavarti koo dicketin banaane key liye unaki uchch pratikriyashilta key kaaran alag naheen kiya jaa sakata haye. inn punarvyavasthaon koo asantript yaugikon kii upasthiti mein kiya jaataa haye joe "inn seetu" utpann keaten key saath [2 + 2] cyclodation seey gujarate hain. jaba alkine kii upasthiti mein keteen banate hain tou way ack pratisthaapit sugandhit valay (yojana 2) utpann karane key liye pericyclic pratikriyaon key madhyam seey aage badhate hain. uchch oorjaa vaale cyclobutanone praarambhik samagri key upayog seey bachana pratisthaapit sugandhit yaugikon kii ack vistrit vividhata taka pahunch pradaan kartaa haye.
yeh pratikriya wolf-dutz pratikriya key liye kaafee poorak haye. yeh ack carbine kaa ack alkine yaa alkien (vishesh roop seey ack dhaatu carbonyl samooh key liye samanvit ack carbine deats pratikriya mein) mein ack [2 + 1] cyclodation haye joe pratisthaapit sugandhit phenol kaa utpaadan kartaa haye.
tantra.
pratikriya chaar baad kii pericyclic pratikriyaon (yojana 3) key ack cascade key madhyam seey aage badhati haye. 80 degree celsius seey oopar ack cyclobutanone koo germ karane seey ack vinail kettin utpann karane vaale chaar-electron electrocyclic daraar kii shuruat hoti haye joe ack regiosphacific [2 + 2] cyclodation (yojana 4) mein ack acetylene key saath pratikriya karati haye. 2-vinilcyclobutanone key prativarti electrocyclic vichhedan seey ack dynilketine praapt hotaa haye. dynilketine taba ack hexadianone madhyavarti dene key liye chhah-electron vidyutchakran seey gujarta haye joe teji seey ack atyadhik pratisthaapit phenol yaa nafthol sanrachanaon koo utpann karane key liye toutomerise kartaa haye.
sanshodhit benzanulation pratikriya (yojana 5) key mamle mein; diazocatone kaa vikiran vinail kettin madhyavarti koo utpann karane vaale wolf punarvyavastha koo prerit kartaa haye joe ack [2 + 2] cyclodation mein acetylene key saath pratikriya kartaa haye phir parinami 4-pratisthaapit cyclobutanone kaa chaar-electron cleavage ack dynilketine kaa utpaadan kartaa haye joe phir 2,4-cyclohexanadione dene key liye chhah-electron electrocyclisation seey gujarta haye joe antim sugandhit utpaad koo tatomerise kartaa haye.
pratikriya kii sthiti.
ack vishisht danheiser benzanulation pratikriya koo cyclobutanone kii thodi adhikta key saath 80-160 °C parr germ kiye gaye toluen mein cyclobutanone key 0.4-2.0 m ghol key saath chalaaya jaataa haye. alkine key judane parr ack [2 + 2] cyclodation hotaa haye. atirikt vinailketin (yojana 6) key saath phenolic utpaad kii pratikriya seey baney ester side utpaad koo saponife karane key liye kachche annelation utpaad koo methanol mein 10 pratishat potasium hydroxide key saath upchaarit kiya jaataa haye. 
diazocatone seey shuru honey vaali doosari peedhi kii pratikriya key liye, pratikriya keaton key 0.7 meater ghol key vikiran dwara acetylene key 1.0-1.2 samkaksh key saath kii jaati haye. ack prakaash rasayanik reactor mein 254 nm parr ack cumm dabaav vaale paaraa-vaashp deepak kaa upayog 5-8 ghanton key liye kiya jaataa haye jaba taka kii sabhi diazocatone kaa sevan naheen hoe jaataa haye jaisa kii tlc vishleshan dwara nirdhaarit kiya jaataa haye. dichloromethane, chloroform aur 1,2-dichloroethane, sabhi annulation pratikriya key liye upayukt vilaayak hain.
abhikarmak taiyari.
cyclobutanone koo mool roop seey 3-bromocyclobutano aur 3-chlorocyclobutano agraduton seey sanshleshit kiya gayaa thaa joe dou swatantra maargon key madhyam seey ack elin aur ack keteen seey taiyar kiye gaye they. yojana 7 ack elin seey cyclobutanone seey taiyari koo darshaati haye.
sakriya alchaeoxiacetylene koo ester seey trisopropylsilicillinalite kii ekal-bartan taiyari mein sanshleshit kiya jaa sakata haye. cyliloxiacetylene cyclobutanone (yojana 8) key saath keatein aur vinailketin key saath [2 + 2] cyclododation pratikriyaon mein alcoxiacetylene key liye upayogi vikalp hain.
diazokitone koo aasaani seey upalabdh keaton yaa carboxylic acid agraduton seey ack charan mein asyl chloride mein diazomethane key jodd seey sanshleshit kiya jaa sakata haye. ack diazo samooh hastaantaran vidhi kaa upayog α, β-asantript keaton kaa utpaadan karane key liye kiya jaa sakata haye. classen formillation charan key liye utpann lithium annolates key trifluoroacetylation koo pratisthaapit karke vikrit diazo hastaantaran drishtikon kii paaramparik vidhi mein sudhaar kiya gayaa haye. iss prakriya mein pramukh charan trifluoroethyllitrophy (tii. aff. ee. aeye.) (yojana 9) kaa upayog karke sambandhit α-trifluoroacetyl vyutpann key liye keaton praarambhik samagri kaa sakriyan haye.
alkine yaa catanophiles koo vibhinn tarikon seey sanshleshit kiya jaa sakata haye. trialkilsilinoxylicsial utkrisht catanophiles saabit hue hain. yeye alkine vaarshik pratikriya mein pratikriya karate hue resourcinol monosilil eather banaate hain jinhen halki pratikriya sthitiyon mein dee-protect kiya jaa sakata haye.
alcoxiacetylene banaane key liye (jaid)-2-halovinil eather kaa aadhar-prachaarit nirjalikaran alkine sanshleshan (yojana 10) key sabse achchi tarah seey sthaapit maargon mein seey ack haye.
sanshleshit alkine koo phir benzene yaa tolune mein atirikt cyclobutanone kii upasthiti mein germ kiya jaataa haye joe benzanulation pratikriya shuru kartaa haye. tetrahydrophuran mein aine-buu4nf key saath upchaar vaanchhit diol banaane key liye cyloxy samoohon koo hataa detaa haye.
daira.
alkynil eather aur cyloxiacetylence sugandhit annelation key liye aadarsh jodee saabit hue hain. pratikriyaon koo sakriya visham-pratisthaapit alkine aur gair-sakriya acetaline donon key saath chalaaya jaa sakata haye. alkynil theoether aur yanamine kaa upayog annelation pratikriya mein abhikarakon key roop mein kiya gayaa haye.
sanyugmit anine kaa upayog cobalt dwara utprerit benzanulation pratikriyaon key liye bhee kiya gayaa haye. iss prakaar key benzanulation mein ack [4 + 2] cyclodation shamil hotaa haye jisake baad 1,3-hydrogen shift hotaa haye. dichloromethane mein, samamit benzanulation utpaad praapt hotey hain lekin tetrahydrophuran (thf) mein, asmamit benzanulation utpaad achchi regioselectivity key saath praapt kiye gaye they. yeye pratikriyaaen ack vilaayak aashrit benzainulan pratikriya (yojana 11) key liye pouder jink aur jink iodide kii upasthiti mein 1,3-biss (diphenylphosphino) propen (dee. pee. pee. pee.) pratisthaapit cobalt utprerak kaa upayog karati hain. dichloromethane mein ehbi kaa anupaat 90 pratishat kii samagr sanyukt upaj key saath 78:22 haye aur thf mein anupaat 85 pratishat kii sanyukt upaj key saath 7:93 (ehbi) mein badal gayaa haye.
paladium-utprerit benzanulation koo elilic yaugikon aur alkine kaa upayog karke vikasit kiya gayaa haye. yeh paladium utprerit pratikriya antar-aur antahaanvik donon roopon mein kii gaee haye. cashionic paladium complexes [(η3-c3h5) pd (ch3cn) 2] (bf4) 4-octine kii adhikta key saath pratikriya kartaa haye jaba triphenylphosphine kii upasthiti mein 80 degree celsius taka germ kiya jaataa haye joe sugandhit yaugik 1-methyl-2,3,4,5-tetrapropylbangine (yojana 12) banaata haye. yeh nirdhaarit kiya gayaa thaa kii paladium utprerak key thheek ack samkaksh kii upasthiti (jisase elil samooh antim sugandhit sanrachana mein jodata haye) utprerit benzanulation key liye achchi upaj mein honey key liye mahatvapurna haye.
iss utprerit pratikriya koo utprerak [pd2 (dba) 3] chcl3 aur triphenylphosphine (dba = dibenzylideneacetone) (yojana 13) key saath elil substrate key liye bhee anukoolit kiya gayaa thaa.
kull sanshleshan mein anuprayog.
mycophenolic acid ack "penicillium" chayapachaya haye jise mool roop seey ack pramukh benzanulation charan key madhyam seey taiyar kiya gayaa thaa. ack alkine aur ack cyclobutanone koo 73 pratishat upaj (yojana 14) mein ack hii charan mein ack pratisthaapit phenol banaane key liye pratikriya dee gaee thee. mycophenolic acid koo 17-19% kii samagr upaj mein nau charanon mein taiyar kiya gayaa thaa.
danheiser dwara kiye gaye atyadhik pratisthaapit indol key sanshleshan mein, pramukh charan atyadhik pratisthaapit anilyn vyutpannon kaa utpaadan karane key liye cyclobutanone aur yanamides kaa upayog karke ack benzanulation pratikriya thee. iss mamle mein, "ortho" sthiti koo vibhinn pratisthapanon key saath karyatmak kiya jaa sakata haye. vibhinn visham-chakran pratikriyaon key saath benzanulation pratikriya key baad pratisthaapit indol (yojana 15) taka pahunch pradaan kii jaa sakati haye.
 
danheiser ney polycyclic benzofused nitrogen heterocycle key sanshleshan key liye yanamides key saath benzanulation kaa bhee upayog kiya, jisake baad ack anticancer agent (+)-fr900482 key kull sanshleshan key liye ring-closing metathesis (yojana 16) kaa upayog kiya.
kovalsky ney pahali baar cyloxiacetylene key saath benzanulation pratikriya kaa upayog kiya, unhein cyclobutanone key saath pratikriya karate hue δ-6-tetrahydrocanabinol (yojana 17) key kull sanshleshan key liye ack pratisthaapit phenol koo sanshleshit kiya.
benzanulation pratikriya kaa upayog smith dwara belnakar vishvakosh key kull sanshleshan mein vishesh roop seey (−)-cylandrocyclophane f mein kiya gayaa thaa. unhone lakshya taka pahunchane key liye ack olephine metathesis pratikriya key liye dihydroxyl sugandhit madhyavarti kaa nirmaan karane key liye ack cyloxialkine aur ack cyclobutanone kii pratikriya kaa upayog kiya (yojana 18).
jhaang aur taiyar dwara dictudendrins key 6-charaniya sanshleshan mein danheiser benzanulation kaa ack utkrisht anuprayog pradarshit kiya gayaa thaa. unhone eril yinol eather (eril kettin agradoot) key beach ack hetero-[2 + 2] cycloloadtion kaa upayog karke cyclobutanone substrate praapt kiya, aur nimnalikhit benzanulation ney dictudendrins aff, aich aur aaee key carbazole colley key teji seey nirmaan koo saksham kiya. danheiser benzanulation kaa safal upayog jhaang koo aur dictiodendrin praakritik utpaadon key sabse cumm sanshleshan koo praapt karane key liye taiyar karane kii anumati detaa haye.

