ischemic poorv-shart

ischemic preconditioning (aaee. pee. see.) kaee prakaar key ootakon mein rakt kii aapoorti key nuksan key liye pratirodh paida karane key liye ack prayogaatmak takneek haye, aur iss prakaar oxygen. hriday mein, aaee. pee. see. ack aantarik prakriya haye jisamen ischemia key baar-baar chhote episode myocardium koo baad mein ischemic upman seey bachaate hain. isaki pehchaan pahali baar 1986 mein muri aur anya logon dwara kii gaee thee."iss samooh ney anaesthetised khule seene vaale kutton koo 5 minut kii coronary dhamani key avrodh kii chaar avadhi key liye ujagar kiya, jisake baad coronary dhamani key 40 minut key nirantar avrodh kii shuruat seey pahale 5 minut kii avadhi key pratikshep key liye. niyantran karane vaale jaanvaron mein "ischemic poorv-conditioning" kii aisee koee avadhi naheen thee aur kutton kii tulanaa mein unake infarct kaa aakar bahut badaa thaa. iss ghatana key peechhe key sateek aanvik maargon koo abhee taka poori tarah seey samajha naheen gayaa haye.
prishthabhoomi.
yadi kissy anga yaa ootak koo rakt kii aapoorti thode samay key liye (aamtaur parr paanch minut seey cumm) baadhit hoe jaati haye, tou phir bahaal hoe jaati haye taaki rakt pravaah phir seey shuru hoe jaae, aur prakriya koo dou yaa dou seey adhik baar dohraya jaae, tou ootak yaa anga key neeche kii koshikaaen ack antim ischemic upman seey majboot roop seey surakshit rahati hain jaba rakt kii aapoorti poori tarah seey aur sthaayi roop seey kaat dee jaati haye.
aaee. pee. see. dwara pradaan kiye jaane vaale surakshaatmak prabhaav mein suraksha kii dou khidakiyan hoti hain. pahala 4 seey 6 ghante key beach rahata haye aur ise shaastriya yaa praarambhik poorv shart naam diyaa gayaa haye. doosari vindo 24 ghante mein shuru hoti haye aur ischemia aur reperfusion uttejana key 72 ghante baad taka rahati haye.
ack prayogaatmak setting mein yadi janwar kii baain poorvavarti avrohi coronary dhamani koo lagaa diyaa jaataa haye tou downstream cardiac cellular maas infarct hoe jaataa haye aur ghayal hoe jaataa haye aur phir marr jaataa haye. doosari or yadi ootak aaee. pee. see. key adheen haye tou neeche kii or cellular dravyamaan kewal nyuntam seey mamuli kshati banaae rakhega. aaee. pee. see. jaiv rasayanik ghatnaaon key ack cascade koo shuru karke ootak kii raksha kartaa haye joe ootak kii oorjaa key upp-regulation kii anumati detaa haye. iss ghatana kaa sthaan antahkoshikiya anga, mitochondrian haye.
vibhinn bahirjaagatik parisanchari ligand jaise delta sakriya opiates aur opioids kii jaanch aaee. pee. see. kii ghatana kaa anukaran karati haye iss prakaar aaee. pee. see. rook-rook curr bandhan prakriya key binaa neeche kii or ootakon kii raksha karati haye.
ischemia aur reperfusion chot key madhyam seey hriday koo hui chot koo seemit karane key prayaas mein coronary hriday roga key kshetra mein naidaanik abhyaas mein aaee. pee. see. kii nakal karane yaa usey baahar nikaalane key tarikon kaa prayaas kiya gayaa haye. aisee chot taba hoti haye jaba ack rogi koo ack teevra myocardial infarct hotaa haye jisake baad yaa tou percutaneous coronary intervention yaa thrombolysis dwara reperfusion hotaa haye.
praarambhik poorv shart.
praarambhik poorv-anukoolan koo adenosine, opiates aur bradykinin kii sthaaniya kriya seey uttejit maanaa jaataa haye, joe sabhi ischemic koshikaon dwara antarjanit roop seey jaari kiye jaate hain. pratyek padaarth kii upasthiti kii aavashyakta naheen haye lekin yadi way hain tou suraksha adhik shaktishali haye. way jee-protein yugmit maargon koo sakriya karate hain, joe ack antim-prabhaavak key liye ack surakshaatmak sanket leey jaataa haye. sarcolemamal aeye. tii. pee.-sensitive potasium channel, mitochondrial aeye. tii. pee.-sensitive potasium channel, mitochondrial pargamyata sankraman chhidra, pratikriyaasheel oxygen prajaati utpaadan, chloride channel, aantarik sudhaarak potasium aayan channel aur connection 43 sambandhit channel sahit yeh kyaa hoe sakata haye, isake liye kaee sujhaav diye gaye hain.
poorv sharton kii haani.
yeh bhee dikhaaya gayaa haye kii aaee. pee. see. kaa surakshaatmak prabhaav hypercholesterolemia, hyperglycemia, uchch raktchaap, cardiac hypertrophy aur hyperhomocystenamia jaisi rogjanak sthitiyon dwara dabaa diyaa jaataa haye. 
aavedan.
manushyon kaa ekmatra samooh joe delta gatividhi key saath ack opioid key lambe samay seey sampark mein hain, way methadone-banaae rakhe gaye rogi hain jinka puraane dard yaa opioid kii lutt key liye ilaaj kiya jaataa haye. inn rogiyon mein samanya aabaadi kii tulanaa mein adhik coronary jokhim profile hoti haih
methadone-upchaarit aabaadi key praarambhik aur abhee taka aprakaashit sarvekshan myocardial ischemic ghatnaaon seey uchch star kii suraksha kii or ishara karate hain. ack prakaashit adhyayan, newyork shahar key mukhya chikitsa pareekshak key karyalaya seey ack shav pareekshan shrinkhala ney coronary occlusive roga key liye kaafee cumm saboot pradarshit kiye. iss postmortem jaanch mein methadone key saath aaee. pee. see. key anukaran kaa mulyankan naheen kiya jaa sakaa.
doorasth poorv aur post conditioning.
coronary dhamani koo avaruddh karane key bajaay, shalya chikitsa seey pahale raktchaap cuff kaa upayog karke brackial dhamani koo avaruddh karke isi tarah key parinam dekhe gaye hain. kuchh shodhon seey yeh bhee pataa chalata haye kii stroke, chronic cerebral hypoperfusion yaa dill key daure key baad ischemic conditioning bhee fayademand haye.

