
aine. ee. dee. dee. 8

aine. ee. dee. dee. 8 ack protein haye jise manushyon mein "aine. ee. dee. dee. 8" jeane dwara kootbaddh kiya jaataa haye. ("sacromyces serevisia" mein iss protein koo rubb1 key roop mein jaanaa jaataa haye) yeh ubquitin jaisa (ubl) protein seemit sankhya mein cellular protein key saath sahsanyojak roop seey sanyugmit hoe jaataa haye, ack prakriya mein jise neddlation kahaa jaataa haye. maanav aine. ee. dee. dee. 8 ubquitin key liye 60 pratishat emino acid anukram pehchaan saajha kartaa haye. aine. ee. dee. dee. 8 sanshodhan key praathamik gyaat substrate cullin-adharit ee3 ubquitin ligses kii cullin upa-ikaaiyaan hain, joe kewal nedadilated honey parr sakriya hoti hain. ligage parisar mein ee2 kii bharti key liye unakaa nedudilation mahatvapurna haye, iss prakaar ubquitin sanyugman kii suvidha pradaan kartaa haye. isaliye aine. ee. dee. dee. 8 sanshodhan koo koshika chakr kii pragati aur koshika-asthipanjar viniyaman mein shamil kiya gayaa haye.
sakriyan aur sanyugman.
ubiquitin aur sumo kii tarah, nedd8 koo isaki see-terminal poonchh koo sansaadhit karane key baad cellular protein mein sanyugmit kiya jaataa haye. aine. ee. dee. dee. 8 sakriya karane vaalaa ee1 enzyme ack heterodymer haye joe aipbeepi1 aur yuu. bee. aeye. 3 upa-ikaaiyon seey banaa haye. pbp1/uba3 enzyme mein kramshah ubquitin ee1 enzyme key aine-aur see-terminal hisson key liye samroopata haye. yuu. bee. aeye. 3 upa-ikai mein utprerak kendra hotaa haye aur yeh ack uchch-oorjaa theolister madhyavarti banaakar aeye. tii. pee.-nirbhar pratikriya mein aine. ee. dee. dee. 8 koo sakriya kartaa haye. sakriya aine. ee. dee. dee. 8 koo baad mein yuu. bee. see. aich. 12 ee2 enzyme mein sthanantarit curr diyaa jaataa haye, aur phir upayukt ee3 ligses kii upasthiti mein vishisht substrate mein sanyugmit kiya jaataa haye.
aine. ee. dee. dee. 8 key liye substrate.
jaisa kii braun aitt all dwara sameeksha kii gaee haye.sabse achchi visheshta vaale sakriya-aine. dee. dee. 8 substrate cullin (kull 1,23,4aeye, 4bee, 5, aur 7 aur maanav koshikaon mein park) hain, joe cullin-ring ubquitin ligses (see. aar. ell.) key liye aanvik machaan key roop mein kaam karate hain. neddlation key parinamswarup ack sanrakshit cullin lycine avashesh parr ack neddy8 bhaag kaa sahsanyojak sanyugman hotaa haye. cullin neddlation sanrachanaatmak parivartanon key madhyam seey crill sarvavyaapi gatividhi koo badhaata haye joe lakshit protein mein ubquitin hastaantaran koo anukoolit kartaa haye. 
hataane.
kaee alag-alag protease hain joe protein sanyugma seey nedd8 koo hataa sakate hain. yuu. see. ell. 1, yuu. see. ell. 3 aur yuu. aiss. pee. 21 protease mein aine. ee. dee. dee. 8 aur yuu. bee. see. aaee. tii. aine. key liye dohri vishishtata haye. aine. ee. dee. dee. 8 hataane key liye vishisht protease cop9 signalosome hain joe aiss. see. aff. ubquitin ligses kii kull1 upa-ikai seey aine. ee. dee. dee. 8 koo hataa detaa haye, aur aine. ee. dee. pee. 1 (yaa daine1, saine. pee. 8).
dee. aine. aeye. marammat mein bhoomika.
jaisa kii braun aitt all dwara dikhaaya gayaa haye.dee. aine. aeye.-kshati sthalon parr aine. ee. dee. dee. 8 kaa sanchay ack atyadhik gatishil prakriya haye. dee. aine. aeye. nucleotide chhedan marammat (aine. ee. aar.) key vaishvik genome marammat (jee. jee. aar.) upa-maarg kii ack chhoti avadhi key dauran neddlation kii aavashyakta hoti haye. nerr key jee. jee. aar. mein, yuu. vee. vikiran key kaaran dee. aine. aeye. kshati key baad, dee. aine. aeye. kshati badhyakari protein 2 (dee. dee. bee. 2) parisar mein kull4aeye aine. ee. dee. dee. 8 dwara sakriya kiya jaataa haye, aur yeh jee. jee. aar.-genner koo kshati koo door karane key liye aage badhane kii anumati detaa haye. 
dohare-strand break kii marammat mein bhee neddlation kii bhoomika haye. gair-samroop anta judaav (aine. aich. ee. jey.) ack dee. aine. aeye. marammat maarg haye jiska upayog aksar dee. aine. aeye. double-strand break kii marammat key liye kiya jaataa haye. iss maarg mein pahala kadam kyu70/kyu80 heterodymer parr nirbhar kartaa haye joe dee. aine. aeye. key chhoron koo gherne vaali ack atyadhik sthir valay sanrachana banaata haye. lekin koo heterodymer koo hataane kii aavashyakta hoti haye jaba nez puuraa hoe jaataa haye, yaa yeh pratilekhan yaa pratikriti koo avaruddh kartaa haye. prakriya poori honey key baad marammat sthal seey koo aur anya nez karakon key nikalane koo badhaava dene key liye koo heterodymer koo dee. aine. aeye.-kshati aur nedudilation-nirbhar tareeke seey sarvavyaapi kiya jaataa haye. 
cancer chemotherapy mein.
jaisa kii jinn aur robberston ney apani sameeksha mein charcha kii haye, dee. aine. aeye. marammat jeane koo isake pravartak key hypermethylation dwara chup karaana cancer kii pragati kii disha mein ack bahut hii praarambhik kadam hoe sakata haye. pratilekhan star parr dee. aine. aeye. marammat jeane key jeane koo shaant karane kaa prastaav dee. aine. aeye. marammat jeane mein roganu-rekha utparivartan key samaan kaary karane key liye haye. kissy bhee tantra dwara dee. aine. aeye. marammat kshamata kaa nuksan genome asthirta kaa parichay detaa haye aur koshika aur usake vanshajon koo cancer kii pragati key liye purvanirdhaarit kartaa haye. epigenetically silence dna repair jeane 17 sabse aam cancers mein aksar hotey hain (ee dekhein.jee. cancer mein dee. aine. aeye. key hypermethylation kii aavritti jeane kii marammat karati haye).
jaisa kii oopar charcha kii gaee haye, sakriya-aine. dee. dee. 8 kii aavashyakta dou dee. aine. aeye. marammat maargon mein haih nerr aur aine. aich. ee. jey.. yadi aine. ee. dee. dee. 8 kaa sakriyan baadhit hotaa haye, tou nerr yaa aine. ee. jey. kii prerit kamee vaali koshikaaen dee. aine. aeye. kii kamee kii marammat key kaaran marr sakati hain jisase dee. aine. aeye. nuksan jamaa hoe jaataa haye. aine. ee. dee. dee. 8 avrodh kaa prabhaav samanya koshikaon kii tulanaa mein cancer koshikaon key liye adhik hoe sakata haye yadi vaikalpik maargon mein sakriya dee. aine. aeye. marammat jeane key poorv epigenetic maun key kaaran cancer koshikaon mein swatantra roop seey dee. aine. aeye. marammat kii kamee haye (synthetic ghaataktaa dekhein). 
pevonedistat (aim. ell. aine. 4924), aine. ee. dee. dee. 8 key sakriyan koo rokane vaali ack dawa, ney aaee. dee. 1 mein chaar charan I naidaanik cancer parikshanon mein ack mahatvapurna chikitsiya prabhaav dikhaaya haye. inmein teevra myeloid leukemia aur myelodysplastic syndrome, relapsed/refractory multiple myeloma yaa lymphoma, metastatic melanoma aur unnat thhos tumour key khilaf pevonedistat pareekshan shamil hain.
preclinical adhyayan mein.
pparγ neddlation.
edipocytes (vasaa koshikaon) key bheetar edipogenesis aur lipid sanchay mein pee. pee. aar. jee. aim. kii mahatvapurna bhoomika haye. sakriya aine. ee. dee. dee. 8 pee. pee. aar. jee. aim. koo sthir kartaa haye, jisase edipogenesis mein vriddhi hoti haye. choohon key saath prayogon mein, pavonedistat, nedd8 key sakriyan koo rokane vaali ack dawa, uchch vasaa aahar-prerit motape aur glucose asahishnuta koo rokti haye.
aine. aff.-key. bee. aur aine. ee. dee. dee. 8.
aine. aff.-key. bee. kii pratilekhan gatividhi mukhya roop seey avarodhak aaee. key. bee. protein (aaee. key. bee. aeye. aur aaee. key. bee. bee. aeye.) key saath shaaririk baatchit dwara niyantrit kii jaati haye, joe isake paramanu sthanantaran koo rokti haye. aaee. key. bee. kii aaee. key. bee. aeye. upa-ikai kaa ksharan sarvavyaapi dwara madhyasthata kii jaati haye, aur yeh sarvavyaapeeta neddlation parr nirbhar karati haye. pavonedistat (aim. ell. aine. 4924) aine. ee. dee. dee. 8 key sakriyan koo rokta haye, joe taba aaee. key. bee. aeye. key sarvavyaapeekaran koo rokta haye, aur yeh naabhik mein aine. aff.-key. bee. sthanantaran koo rokta haye.
pevonedistat, aine. aff.-key. bee. parr apane prabhaavon aur aine. aff.-key. bee. (microrna-155) key lakshya key madhyam seey, leukemic koshikaon key saath utkeern choohon key astitva koo lamba curr diyaa.
colorectal cancer.
pavonedistat dwara aine. ee. dee. dee. 8 sakriyan kaa avrodh 16/122 (13 pratishat) colorectal cancer (see. aar. see.) koshika rekhaaon mein vriddhi giraftari aur apoptosis koo prerit karane key liye paaya gayaa. rogi seey praapt tumour zenographts mein aage key vishleshan seey pataa chalaa kii pavonedistat kharaab roop seey vibhedit, uchch shreni key shleshm see. aar. see. parr prabhaavi haye. 
antahkriyaaen.
aine. ee. dee. dee. 8 koo nimn key saath antahkriya karate hue dikhaaya gayaa haih

