
tcam

tcam ack protein haye jise manushyon mein "tcam" jeane (tii-cell sakriyan avarodhak, mitochondrial) dwara kootbaddh kiya jaataa haye.
jeane.
jeane gunasutra 3 parr sthit haye, 3p21.31 sthiti mein, aur 71,333 aadhar lambe hain. chhavi kaa ack chitra neeche fig.1.2 mein dikhaaya gayaa haye kii tcam protein 496 avashesh lamba haye aur iska vajan 57925 daa haye. yeh chaar alag-alag samroopon mein maujood haye. vibhinn prajaatiyon key beach tuckam atyadhik sanrakshit haye, lekin gyaat karyon key protein parivaaron key liye koee samroopata naheen khoji gaee thee.
pratilekh.
8 vaikalpik roop seey splies kiye gaye exon hain, joe 4 pratilekh roopon koo kootbaddh karate hain. praathamik pratilekh, joe 3520 bee. pee. haye, orthologue key beach achchi tarah seey sanrakshit haye, jisamen maanav isophorm 1 kii orthologous protein key saath uchch pehchaan haye. x1 pratilekh mein 11 exon hotey hain, joe ack polypeptide utpann karate hain joe lambai mein 496 amino acid avashesh hain.
protein.
samanya guna.
isoelectric bindu maanav protein (6.81) key liye ausat seey kaafee adhik haye.
sanrachana.
daaeen or dikhaaya gayaa haye kii protein kii ack anumaanit tritiyak sanrachana haye. yeh jyaadaatar lambe alfa-hellis seey banaa haye jisamen kaee kundal kshetra aur protein kii lambai key dauran faile hue taar hotey hain. protein key chhoron mein aine-aur see-terminal chhoron key vipareet kundal kshetra hotey hain.
abhivyakti.
shareer key adhikansh ootakon mein tuckam koo madhyam roop seey vyakt kiya jaataa haye (50-75%). haalaanki, aine. see. bee. aaee. jio parr ack adhyayan mein tii. see. aaee. aim. aar. aine. aeye. abhivyakti parr roga kii sthiti key prabhaav parr charcha karate hue paaya gayaa kii aich. pee. vee. nakaratmak ootakon kii tulanaa mein aich. pee. vee. sakaratmak ootakon mein protein abhivyakti vaastav mein badhee thee. ack anya adhyayan mein paaya gayaa kii type 2 madhumeh aur insulin pratirodh vaale vyaktiyon mein tuckam abhivyakti badhee thee. vibhinn mamalon mein tcam kii abhivyakti vishisht roga kii sthiti parr nirbhar prateet hoti haye.
upkoshikiya sthaaniyakaran.
protein mein ack mitochondrial signal peptide hotaa haye joe ise mitochondrial matricks mein sthaaniyakrit kartaa haye. expassy localization software key madhyam seey vishleshan ney iss khoj kii pushti kii. maanav protein kaa uchch summ-vidyut bindu mitochondrial matricks key uchch ph key kaaran mitochondrial sthaaniyakaran key liye aur saboot pradaan kartaa haye.
anuvaad key baad key sanshodhan.
daraar vaali jagahen.
aine-terminus seey 26 emino acid koo hataane key liye shuru mein protein koo alag kiya jaataa haye. yeh mitochondrian mein sthaaniyakrit honey key baad ack sanket peptide kaa pratinidhitva kartaa haye.
phosphorylation.
kaee anumaanit phosphorylation sthal hain, jaisa kii daaeen or key chitra mein dekhaa gayaa haye. threonin yaa tyrosine avasheshon kii tulanaa mein sirin avasheshon key phosphorylation seey gujarane kii adhik sambhavana hoti haye.
oh-linked glycosylation.
daaeen or kaee anumaanit oh-link saaiten dikhaai gaee hain. abb taka koee bhee prayogaatmak roop seey nirdhaarit naheen kiya gayaa haye.
samroopata aur vikas.
homolog.
aiss. dee. aiss. see. workbench kaa upayog karke "homo sapiens" tuckam aur "danio rario" (zebrafish) homolog kaa ack sanrekhan kiya gayaa thaa. 1817 key vaishvik sanrekhan score key saath donon orthologue key beach lagbhag 55 pratishat pehchaan haye. donon orthologue apane anukramon kii sampoornata mein lagaatar samaan hain. donon jeenon key beach antar gair-sanrakshit aur ardh-sanrakshit avasheshon key yaadrichhik khandon key kaaran haye joe donon sanrekhanon mein bikhare hue hain. yeh antar donon jeevon key beach gair-sambandh key kaaran hoe sakata haye.
vikaasvaadi itihas.
cytochrome see kii tulanaa mein bahut teji seey, lekin fibrinogen kii tulanaa mein thodaa dheema.
kaary.
kaary key baare mein jyada jaankaari naheen haye; yeh anuman lagaaya jaataa haye kii yeh protein tii-koshikaon key apoptosis mein bhoomika nibha sakata haye. tuckam mitochondria key madhyam seey janmajaat pratiraksha sanket mein ack bhoomika nibha sakata haye.
naidaanik mahatva.
vogel aur anya logon dwara ack shodh adhyayan kiya gayaa thaa. unhone pahale paaya kii tuckam atyadhik roop seey sahishnuta-vikasit pratyaropan rogiyon key graft aur ootakon mein vyakt kiya jaataa haye aur protein mitochondria mein sthaaniyakrit hotaa haye. iss adhyayan mein, unhone paaya kii tcam cd11see (+) dendritic koshikaon key saath baatchit kartaa haye aur niyantrit hotaa haye. hendrickson aitt kaa ack aur lekh. ell ney sankshep mein tcam kaa ullekh kiya haye. unhone paaya kii paramanu-encoded mitochondrial jeane mein aanuvanshik roop pragati koo prabhaavit karate hain. teesara lekh ack aur shodh haye joe iss baat key pramaan paataa haye kii tcam (mitochondrial jeane key saath) kaa upayog rogiyon mein ack marker key roop mein kiya jaa sakata haye taaki yeh anuman lagaaya jaa sakey kii kyaa way ack allographt koo sweekaar curr sakate hain yaa ise aswikar curr sakate hain.

