
dostarlimab

gemperly brand naam seey becha jaane vaalaa dostarlimaib ack monoclonal antibody haye jiska upayog endometrial cancer key ilaaj key liye cancer-rodhi dawa key roop mein kiya jaataa haye. dostarlimab ack prograam kiya gayaa mrityu receptor-1 (peedi-1)-avarodhit monoclonal antibody haye.
america mein report kiye gaye sabse aam dushprabhavon mein thakan/astheniya, matali, dast, anaemia aur kabj shamil hain. europeeya sangh mein report kiye gaye atirikt dushprabhavon mein ulti, jodon kaa dard, khujali, chakatte, bukhaar aur hypothyroidism (thyroid harmon kaa nimn star) shamil hain.
dostarlimab koo aprail 2021 mein sanyukt raajya america aur europeeya sangh donon mein endometrial cancer key ilaaj key liye manjuri dee gaee thee.
garnet pareekshan key aadhar parr, dostarlimab ney aprail 2021 mein americi khaadya aur dawa prashaasan (fda) seey twarit anumodan praapt kiya, aur farwari 2023 mein poorna anumodan praapt kiya.
chikitsa upayog.
sanyukt raajya america mein, dostarlimaib koo visangat marammat kii kamee (dee. aim. aim. aar.) key saath vayaskon key upchaar key liye sanket diyaa jaataa haye, jaisa kii ack aff. dee. aeye.-anumodit pareekshan dwara nirdhaarit kiya jaataa haye, joe ack platinum yukt aahar key saath poorv upchaar parr yaa usake baad aage badhaa haye. jaba cancer chemotherapy upchaar kii baat aatee haye tou platinum-adharit agent jaise sisplatin, carboplatin aur oxaliplatin upchaar key mukhya aadhar hain. yeh thhos tumour key upchaar key liye bhee sanket diyaa jaataa haye.
europeeya sangh mein, dostarlimaib koo asantulan marammat kii kamee (dee. aim. aim. aar.)/microsatellite asthirta-uchch (aim. aiss. aaee. aich.) punaravritti yaa unnat endometrial cancer (ee. see.) vaale vayaskon key upchaar key liye monotherapy key roop mein ingit kiya jaataa haye joe ack platinum yukt aahar key saath poorv upchaar parr yaa usake baad aage badhaa haye.
agast 2021 mein, americi khaadya aur aushadhi prashaasan (fda) ney visangat marammat kii kamee (dmmr) punaravritti yaa unnat thhos tumour vaale vayaskon key liye dostarlimaib koo twarit manjuri dee, jaisa kii ack fda-anumodit pareekshan dwara nirdhaarit kiya gayaa haye, joe poorv upchaar parr yaa uska paalan curr rahey hain aur jinake paas koee santoshjanak vaikalpik upchaar vikalp naheen hain.
endometrial cancer.
endometrial cancer (ee. see.) ack aisee bimari haye jahan cancer koshikaaen garbhashay (endometrium) key astar mein rahati hain. antahstar mein sthir rahane seey laker shareer key anya angon mein failane vaale cancer taka, ee. see. mein chaar charan hotey hain. yadi vikas kii shuruat mein pataa chalaa tou iss bimari kaa ilaaj kiya jaa sakata haye. rasayan pratirodhi aim. aiss. aaee.-uchch tumour vaale logon mein, dostarlimaib aur pembrolisumab parr kiye gaye adhyayan tumour key upchaar key liye achchi pratikriya dene key ashajanak parinam pradarshit karate hain.
thhos tumour.
thhos tumour aise tumour hotey hain jinamen koee taral yaa sist naheen hotey hain, joe haddiyon, maanspeshiyon aur angon sahit kaee sthaanon parr hoe sakate hain. thhos tumour key sabse aam prakaar sarcoma aur carcinoma hain. dostarlimaib kaa upayog una rogiyon key liye baar-baar honey vaale yaa agrim tumour key ilaaj key liye kiya jaa sakata haye jinhone vaikalpik upchaar vikalpon kii koshish kii haye.
dushprabhaav.
2 pratishat seey adhik rogiyon mein gambhir pratikool pratikriyaon mein sepsis, teevra gurde kii chot, mootra path kaa sankraman, pett dard aur bukhaar (pyrexia) shamil they.
pratiraksha-madhyasth pratikool pratikriyaaen hoe sakati hain jinamen pneumonitis, brihadantrashoth, hepatitis, antahsraavi roga (endocrinopathy) aur nephrietis shamil hain.
pareekshan key dauran iss dawa koo lete samay sabse aam dushprabhaav dyspania, esthenia, thakan aur matali they.
adhik matra key lakshan dawa key dushprabhaav profile key samaan hotey hain, isaliye isamen mahatvapurna pratiraksha-madhyasth pratikriyaen shamil hoe sakati hain.
pratiraksha-madhyasth pratikool pratikriyaaen.
dostarlimaib ack monoclonal antibody haye joe pratiraksha pratikriya key avrodh koo hataane key liye peedi-1 ligand koo baandhane seey rokane key liye peedi-1 seey judati haye. isake saath, yeh pratiraksha-madhyasth pratikool pratikriyaon key liye jokhim kaa kaaran banata haye. yeye pratikriyaaen gambhir yaa ghaatak hoe sakati hain aur shareer key kissy bhee hisse mein hoe sakati hainh anga yaa ootak.
pratiraksha-madhyasth pratikool pratikriyaon key udaharanon mein pratiraksha-madhyasth pneumonitis, brihadantrashoth, hepatitis, adhivrikk aparyaptata, hypophysis, thyroid vikaar, gurde kii shithilata key saath nephrietis aur twacha sambandhi pratikriyaen shamil hain.
garbhavastha aur stanpan.
dostarlimab bhroon koo nuksan pahuncha sakata haye. bhroon kii mrityu pashu adhyayanon mein isake tantra kii pariksha key madhyam seey bhroon key prati pratiraksha pranali kii pratikriya seey hoe sakati haye. dostarlimab ack maanav immunoglobulin jee (igg4) haye, joe placental barrier key madhyam seey pargaman curr sakata haye. isase vikaasheel bhroon koo nuksan hoe sakata haye kyonki dawa maan seey paarit kii jaa sakati haye.
stun doodh mein dostarlimab kii upasthiti key baare mein detta upalabdh naheen haye.
hepatotoxicity.
dostarlimab praaptakartaon key 15-25% mein seeram aminotransferase aur kshaariya phosphat key liye halke seey madhyam oonchaai kaa kaaran banata haye. samanya seema seey paanch gunaa adhik seeram ault unnayan praaptakartaon key 2-3% mein hotaa haye. dostarlimab seey ilaaj kiye gaye kuchh logon mein pratiraksha sambandhi yakrit kii chot hoe sakati haye.
yakrit kii chot yaa teevra yakrit viphalata key kuchh lakshnon mein peeliya, oopari daaen pett mein dard, jalodar, matali/ulti, aur bhatkaav yaa bhram shamil hoe sakate hain.
pharmacology.
dostarlimab ack maanavakrit igg4 monoclonal antibody haye joe ack mouse antibody seey praapt kii gaee thee jise poorakta nirdhaaran kshetra (cdr) grafting key madhyam seey maanveekrit kiya gayaa thaa. iska seeram aadhaa jeevan 25.4 dinn haye.
anya peedi-1 antibody mein nivolumab (opdivo) aur pembrolizumab (ketruda) shamil they, donon kaa upayog kaee alag-alag prakaar key cancers mein hotaa haye jinamen shaastriya hozkin lymphoma, gurde kii koshika kaa cancer aur stun cancer shamil hain. ack anya peedi-1 antibody samplymab (libtayo) haye jise squamous cell carcinoma, besal cell carcinoma aur gair-chhoti cell fefadon key cancer key upchaar key liye anumodit kiya gayaa thaa.
kaarravaai kaa tantra.
dostarlimab pee. dee.-1 ligand (pee. dee.-ell. 1) aur pee. dee.-ell. 2) key saath apani gatividhi koo avaruddh karane key liye, uchch aatmiyata key saath pee. dee.-1 receptor seey judataa haye. pee. dee.-1 ack saha-avarodhak receptor haye joe tii-cell sahishnuta koo niyantrit karane key liye ack mahatvapurna jaanch bindu protein haye. jaba pee. dee.-1 koo pee. dee.-1 ligand dwara lagaatar uttejit kiya jaataa haye, joe cancer koshikaon mein atyadhik vyakt hotey hain, tou yeh cancer koshikaon koo tii-cell madhyasth pratiraksha pratikriyaon koo chakma dene kii anumati detaa haye. isaliye, inn ligendon key liye peedi-1 key bandhan koo avaruddh karane seey tii-koshikaaen samanya roop seey kaary curr sakati hain aur tumour koshikaon koo pratiraksha nigrani koo darkinar karane seey roque sakati hain. mouse tumour model mein, yeh dikhaaya gayaa thaa kii peedi-1 gatividhi koo rokane seey tumour key vikas mein kamee aaee.
prabhavkarita.
garnet pareekshan mein, dostarlimab ney endometrial cancer vaale logon mein tumour key aakar koo cumm karane mein anukool parinam hassil kiye. adhyayan mein saat alag-alag deshon key endometrial cancer vaale logon koo dekhaa gayaa aur adhyayan kii gaee aabaadi key 42 pratishat mein tumour kaa aakar cumm hoe gayaa.
dee. aim. aim. aar. unnat endometrial cancer mein dostarlimaib anya pee. dee.-1 avrodhakon, jaise kii avelumab aur duravalumab kii tulanaa mein behtar prabhavkarita pradarshit kartaa haye. dawa kii prabhavsheelta koo pratikriya darr seey maapa jaataa haye, joe dostarlimaib key liye 47 pratishat haye.
itihas.
2020 mein, dostarlimab, ack peedi-1 avarodhak, charan I/II aur charan III naidaanik parikshanon seey gujar rhaa thaa.
2020 mein, nirmaata, tesaro ney charan I/II garnet adhyayan seey praarambhik safal parinamon kii ghoshana kii.
2020 mein, garnet adhyayan ney ghoshana kii kii dostarlimaib mein baar-baar yaa unnat endometrial cancer vaale vyaktiyon key ack vishisht upasamuchchay kaa ilaaj karane kii sambhavana haye.
aprail 2021 mein, dostarlimaib koo visangat marammat kii kamee (dee. aim. aim. aar.) key saath baar-baar yaa unnat endometrial cancer key upchaar key liye anumodit kiya gayaa thaa, joe aanuvanshik asaamaanyataaen hain joe dee. aine. aeye. kii marammat koo baadhit karati hain, una vyaktiyon mein jinka pahale platinum yukt aahar key saath ilaaj kiya gayaa thaa.
aprail 2021 mein, americi khaadya aur aushadhi prashaasan (fda) ney dostarlimab-gxley (gemperly, gsk) koo twarit manjuri dee. garnet pareekshan (aine. see. tii. 2715284) mein cohort (aeye1) key aadhar parr prabhavkarita kaa mulyankan kiya gayaa thaa, joe unnat thhos tumour vaale pratibhagiyon mein ack bahu-kendra, bahu-samooh, khule-label pareekshan thaa. aff. dee. aeye. ney unnat yaa aavarti endometrial cancer vaale 71 pratibhagiyon key garnet pareekshan (aine. see. tii. 2715284) key sakshya key aadhar parr dostarlimaib koo manjuri dee, jise bemel marammat kii kamee (dee. aim. aim. aar.) dikhaaya gayaa thaa, aur jisake liye kuchh prakaar kii chemotherapy kaam naheen curr rahee thee yaa abb kaam naheen curr rahee thee. sweekrit sanket key liye upayog kiya jaane vaalaa samooh uttari america aur europe key 7 deshon mein 40 sthalon parr aayojit kiya gayaa thaa.
2022 mein, dostarlimaib key ack praarambhik naidaanik adhyayan ney gudaa cancer key 14 rogiyon mein ack 100% chhoot darr kii soochana dee, jinhen bemel marammat kii kamee thee, ack prakaar kaa aanuvanshik utparivartan joe kewal 5-10% mamalon koo prabhaavit kartaa haye.
farwari 2023 mein, fda ney visangat marammat kii kamee (dee. aim. aim. aar.) punaravritti yaa unnat endometrial cancer vaale vayaskon key liye dostarlimaib-gxley (gemperly, glaxosmithcline llc) koo manjuri dee, jaisa kii ack fda-anumodit pareekshan dwara nirdhaarit kiya gayaa haye, joe kissy bhee setting mein pahale seey platinum yukt aahar parr aage badhaa haye yaa uska paalan curr rhaa haye aur upchaaraatmak sergery yaa vikiran key liye ummidwar naheen hain.
samaaj aur sanskriti.
dostarlimab antarrashtriya gair-swaamitva naam (saraay) haye, aur sanyukt raajya america ney apanaae gaye naam (yuu. aiss. aeye.) haye.
kanuni sthiti.
farwari 2021 mein, europeeya dawa agency (ee. aim. aeye.) kii maanav upayog key liye aushadhiya utpaadon (see. aich. aim. pee.) kii samiti ney ack sakaratmak raay apnai, jisamen aushadhiya utpaad gemperly key liye ack sashart vipanan pradhikaran dene kii sifarish kii gaee, jiska uddeshya kuchh prakaar key aavarti yaa unnat endometrial cancer key upchaar key liye thaa. iss aushadhiya utpaad key liye aavedak jee. aiss. key. (ireland) limitted haye. dostarlimab koo aprail 2021 mein europeeya sangh mein chikitsa upayog key liye manjuri dee gaee thee.
arthshastra.
sanyukt raajya america mein, dostarlimab kii keemat prati khuraak key aspas haye.
jinn logon kaa beema kiya gayaa haye, jinake paas chikitsa beema haye, unhein stree roga sambandhi cancer kii poori dekhbhal milane kii sambhavana cumm hoti haye. niji beema key madhyam seey beemit loga abhee bhee upchaar praapt karate samay aarthik kathinaaiyon kaa anubhav karate hain. beemit naheen honey vaale rogiyon kii niyamit roop seey jaanch naheen kii jaati haye, jisake parinamswarup bimari kaa dair seey nidan hotaa haye.

