
poshan

fostricin ack prakaar kaa polycatoid synthes (pee. key. aiss.) haye joe praakritik utpaad seey praapt hotaa haye, joe mool roop seey mitty key bacteria "streptomyces pulveraceous" seey alag kiya jaataa haye. yeh praakritik utpaadon key ack varg seey sambandhit haye jisamen vishisht roop seey ack phosphat ester, ack α, β-asantript lactum aur "streptomises" dwara utpaadit ack sanyugmit raikhik dyne yaa trine shrinkhala hoti haye. iss varg mein sanrachanaatmak roop seey sambandhit yaugik cytostatine aur phoslactomycin shamil hain. fostricin protein serin/threonin phosphatus key saath-saath dee. aine. aeye. topoisomerase II kaa ack gyaat shaktishali aur chayanaatmak avarodhak haye. protein phosphatus pee. pee. 2aeye. aur pee. pee. 4. (aaee. see. 50 1.5nm aur 3.0nm, kramshah) key khilaf isaki gatividhi key kaaran, joe koshika vikas, koshika vibhajan aur sanket pargaman mein mahatvapurna bhoomika nibhaate hain, fostricin koo isaki antitumer gatividhi "inn vivo" key liye dekhaa gayaa aur leukemia, fefadon key cancer, stun cancer aur andashay key cancer key khilaf "inn vitro" gatividhi dikhaai dee. yeh gatividhi maanav pratiraksha kamee virus-1 (hiv-1) pratilekhan aur pratikriti key saath tumour nigrani mein shamil cytotoxic tii-lymphocytes aur praakritik ghaatak koshikaon koo sakriya karke koshikaon key apoptosis koo niyantrit karane mein pp2aeye kii kathit bhoomika key kaaran maani jaati haye.
jaiv sanshleshan.
fostricin key liye jeane samooh mein 21 khule padhane vaale frame (oh. aar. aff. aiss.) hotey hain joe chhah modular prakaar aaee polycatoid synthes aur saat silai enzymon key liye kootbaddh hotey hain. phos" jeane key bheetar inn enzymon mein namkaran fosa-fossum hotaa haye, halanki sabhi kaa upayog lakshya anu key jaiv sanshleshan mein naheen kiya jaataa haye. fosa-phos mein kootbaddh chhah modular pee. key. aiss. ack loading module, aathh vistaar module aur ack theoesteres domen koo janm dete hain.
paaramparik polycatoid synthes maarg.
loading module asyl carrier protein (acp) key ack asyl samooh mein tethering dwara jaiv sanshleshit maarg shuru kartaa haye.iss starter ikai koo phir module 1 mein leey jaaya jaataa haye jahaan ack malonil samooh malonil-coa dwara jodaa jaataa haye aur usake baad beeta-carbonyl ack ketorductess (kr) enzyme dwara hydroxyl samooh mein cumm hoe jaataa haye joe phir ack nirjalikaran enzyme (dh) dwara "trance" dohare bandhan mein nirjalikaran seey gujarta haye. iss pahale module mein, ack annoil reductage enzyme (er) haye, lekin yeh nishkriya haye. yeh shrinkhala taba module 2 aur module 3 mein dou aur vistaaron seey gujarati haye joe module 1 key samaan hain, kewal unake parinamswarup unake sambandhit β-carbon parr "cis" dohare bandhan hotey hain. abb 8-carbon shrinkhala module 4 mein malonil-coa dwara ack aur vistaar seey gujarati haye, jisake baad ack kr domen dwara kamee hoti haye. module 5 mein, methylmalonil-coa dwara ack vistaar kiya jaataa haye jisamen shrinkhala ack hydroxyl samooh mein ack aur kamee seey gujarati haye. polycatoid madhyavarti koo phir module 6 parr paarit kiya jaataa haye jahaan ack aur malonil-koye load kiya jaataa haye, aur yahaan, ack kamee, phir β-carbon kaa nirjalikaran raikhik shrinkhala key antim dohare bandhan kaa nirmaan kartaa haye. badhati hui shrinkhala iss bindu parr lagbhag poori tarah seey sanshleshit haye aur module 7 aur 8 mein 2 carbon key dou vistaar key madhyam seey lii jaati haye, jinamen seey pratyek mein alkill shrinkhala mein antim dou hydroxyl samoohon kaa utpaadan karane key liye krs hotaa haye. raikhik carbon shrinkhala koo abb poori tarah seey sanshleshit kiya jaataa haye aur ack theoesteres domen (tee) dwara acp seey hydrolyse kiya jaataa haye taaki synthetic key baad key silai charanon seey gujarna padey.
post-synthetic silai.
fostricin key utpaadan key liye post-synthetic tailoring enzyme una chaar karyatmaktaon koo jodate hain joe mool roop seey raikhik anu key pee. key. aiss. maarg mein shamil naheen hain. inn enzymon mein dou cytochrome pee450 enzyme (fossage aur fosk), ack homocerin kinage (phos) aur ack nad-dependent epimerase/dehydrates parivaar protein (fossum) shamil hain. theoesteres kshetra key baad pahala kadam, joe chhah-sadasyiya lactone ring banaata haye, phos dwara see8 parr okseekaran haye, jisake baad phos dwara see9 parr phosphorylation hotaa haye. isake baad antim carbon parr fosk dwara okseekaran hotaa haye, aur anta mein, fosm dwara malonic acid kaa nuksan vaanchhit praakritik utpaad detaa haye.

