
transplacental carcinogenesis

transplacental carcinogenesis carcinogen key "garbhashay mein" sampark key kaaran bhroon kii koshikaon mein genotypic aur/yaa phenotypic parivartanon kii ack shrinkhala haye. vishesh roop seey, inn parivartanon koo unaki metastatic kshamata key aadhar parr ghaatak key roop mein pahachaana jaataa haye.
pratyaropan sthanantaran.
garbhavati maan aur bhroon key beach kaa sambandh aisaa haye kii "koshika seey koshika key seedhe sampark key sabhi sthaanon parr, maatri ootak (decidua aur rakt) extra ambronic koshikaon (trophoblast) key saath juda jaate hain.cunningham key anusaar", garbhadhaaran key baad, bhroon aur maan key beach ack jaiv aanvik sanchaar pranali sthaapit kii jaati haye joe nidation key samay seey pahale seey sakriya hoti haye aur prasav key samay key madhyam seey aur usase aage bhee jaari rahati haye."yeh sanchaar pranali garbhavastha key sabhi pahaluon key liye aavashyak haye. "bhroon poshan aur bhroon vikas jaisi shaaririk prakriyaaen seedhe bhroon/bhroon ootak-nirdeshit maatri pratikriyaon key sanshodhanon seey aage badhati hain."vishesh roop seey, garbhanal maan aur bhroon key beach sthanantaran kaa pramukh sthal haye. garbhanal key madhyam seey bhroon una sabhi padarthon key sampark mein aataa haye joe maan key paridhiya parisancharan mein maujood hotey hain. kull milakar, sigaret key dhuein key bheetar nihit vishaakt padarthon kii prachurta joe maan dwara saans mein lii jaati haye, placental aur bhroon koshika prasaar aur vibhedan koo badalkar seedha prabhaav daalati haye. koshikiya gatividhi kaa mahatvapurna santulan baadhit hotaa haye. "iss tarah key carcinogen key garbhashay key sampark mein aaney aur baad mein cancer key vikas kii soochana bachpan key sabhi cancers key liye sanyukt roop seey aur vishesh roop seey bachpan key teevra lymphoblastic leukemia, lymphoma aur mastishk tumour key liye dee gaee haye."
bhroon koshika samvedansheelta.
garbh key shuruati charanon key dauran bhroon kii koshikaaen carcinogen key prati sabse adhik samvedansheel hoti hain. vishesh roop seey, garbhavastha kii shuruat mein, koshika vibhajan kii uchch darr hoti haye. isake alawa, koshikaaen avinyast visheshtaon koo pradarshit karati hain. yeye yaugik kaarak genotoxic agents key prati iss badhee hui koshikiya samvedansheelta key aadhar koo spasht karate hain. udaaharan key liye, yeh saabit hoe gayaa haye kii sampark key dauran nicotine bhroon koshikaon key receptors seey judataa haye jisake madhyam seey kaee vikaasheel angon aur ootakon mein vikasatmak roop seey mahatvapurna sanket hotaa haye. kyonki inn receptors kaa bandhan bhroon koshikaon kii viniyamit gatividhi seey apratyaashit haye, yeh anuman lagaaya jaa sakata haye kii yeh koshikiya prakriya mein ack vyavadhaan haye joe mahatvapurna sanket, abhivyakti yaa marammat key viniyaman jaise hanikarak prabhaavon kaa kaaran bunn sakata haye. jaisa kii oopar bataaya gayaa haye, yadi yeh sampark garbhavastha key shuruati charanon key dauran hotaa haye, tou bhroon iss tarah key nuksan key prati adhik samvedansheel hoga. receptor binding key alawa, yeh bhee saabit huaa haye kii bhroon key ootakon koo koshika prasaar aur honey vaale vibhedan kii vishal matra key aalok mein "neoplastic parivartanon key visheshaadhikaar praapt lakshyon" key roop mein sandeh kiya jaataa haye. vishesh roop seey, tumour koo failaane vaali koshikaon key madhyam seey paaya jaataa haye. yadi koshikaon kaa prasaar aniyantrit hoe jaataa haye, tou kissy bhee upaay seey, yeh utparivartit gatividhi nishchit roop seey kissy key cancer key vikas kii sambhavana mein vriddhi key jokhim kii visheshta hogi.

