sclerostein

sclerostein ack protein haye joe manushyon mein "soust" jeane dwara kootbaddh kiya jaataa haye. yeh see-terminal cysteine gaanth jaise (see. tii. see.) kshetra key saath ack sraavit glycoprotein haye aur huddy key roopaatmak protein (bee. aim. pee.) virodhi key danne (neuroblastoma mein vibhedak screening-chayanit jeane vichalan) parivaar key saath anukram samaantaa haye. sclerostein mukhya roop seey austiocyte dwara utpaadit hotaa haye lekin anya ootakon mein bhee vyakt kiya jaataa haye, aur huddy key gathan parr anty-anabolic prabhaav padata haye.
sanrachana.
sclerostein protein, jisaki lambai 213 avasheshon kii hoti haye, kii ack maadhyamik sanrachana hoti haye jise protein nmr dwara 28 pratishat beeta sheet (6 strand; 32 avashesh) key roop mein nirdhaarit kiya gayaa haye.
kaary.
manushyon mein gunasutra 17q12-q21 parr sthit soust jeane kaa utpaad sclerostein koo mool roop seey ack gair-shaastriya huddy morphogenetic protein (bmp) virodhi maanaa jaataa thaa. haal hii mein, sclerostein koo ell. aar. pee. 5/6 receptors key liye badhyakari aur doubleu. aine. tii. signalling maarg koo rokane key roop mein pahachaana gayaa haye. doubleu. aine. tii. maarg key avrodh seey huddy kaa nirmaan cumm hoe jaataa haye. halanki antarnihit tantra spasht naheen hain, yeh maanaa jaataa haye kii sclerostein dwara bee. aim. pee.-prerit huddy key gathan kii virodhita doubleu. aine. tii. sanket dwara madhyasthata kii jaati haye, lekin bee. aim. pee. sanket maargon dwara naheen. sclerostein austiocytes aur kuchh chaundrocytes mein vyakt kiya jaataa haye aur yeh austioblast dwara huddy key gathan koo rokta haye.
austiocytes dwara sclerostein utpaadan parathyroid harmon, mechanical loading, astrogen aur cytokine dwara baadhit hotaa haye jisamen prostaglandin ee2, oncostatin aim, cardiotrophine-1 aur leukemia avarodhak kaarak shamil hain. calcitonin seey sclerostein kaa utpaadan badhata haye. iss prakaar, austioblast gatividhi ack nakaratmak pratikriya pranali dwara swa-viniyamit haye.
naidaanik mahatva.
sclerostein protein koo kootbaddh karane vaale jeane mein utparivartan uchch huddy dravyamaan, sclerostiosis aur vaine bukem roga seey judey vikaaron seey judey hotey hain.
vaine bukem roga ack autosomal recessive kankal roga haye jisaki visheshta huddy kii vriddhi haye. ise pahali baar 1955 mein "hyperstosis courticalis generalisata parichit" key roop mein varnit kiya gayaa thaa, lekin 1968 mein ise vartamaan naam diyaa gayaa thaa. khopadi, mandibal, clavical, pasaliyon aur lambi haddiyon key diaphysis mein atyadhik huddy kaa gathan sabse pramukh haye aur poore jeevan mein huddy kaa nirmaan hotaa haye. yeh ack bahut hii durlabh sthiti haye jisamen 2002 mein lagbhag 30 gyaat mamle hain. 1967 mein vaine bukem ney dutch mool key 15 rogiyon mein bimari kii visheshta bataai. sclerostiosis key rogi vaine bukam roga vaale rogiyon seey alag hotey hain kyonki way aksar lambe hotey hain aur unake haath vikrit hotey hain. 1990 key dashak key anta mein, company chiroscience aur cape town vishvavidyalaya key vaigyaanikon ney nirdhaarit kiya kii jeane mein ack "ekal utparivartan" vikaar key liye jimmedaar thaa.
sclerostein antibody.
sclerostein key liye ack antibody vikasit kii jaa rahee haye kyonki protein kii huddy key liye vishishtata haye. isake upayog seey austeoporotic choohon aur bandaron mein preclinical parikshanon mein huddy kii vriddhi mein vriddhi hui haye. ack charan I adhyayan mein, amgen (romozumab) seey anty-clarostine antibody kii ack khuraak seey swasth purushon aur rajonivritti key baad kii mahilaaon mein koolhe aur reedh kii huddy mein huddy kaa ghanatva badh gayaa aur dawa koo achchi tarah seey sahan kiya gayaa. ack charan II pareekshan mein, austeoporotic mahilaaon mein antibody upchaar key ack varsh mein asthi ghanatva mein bisphosphonet aur terriparatoid upchaar kii tulanaa mein adhik vriddhi hui; isake halke injection dushprabhaav they. ellie lilly seey sclerostein key liye ack monoclonal maanav antibody key charan II pareekshan kaa rajonivritti key baad kii mahilaaon parr sakaratmak prabhaav padaa. ack varsh key liye antibody key masik upchaar ney placebo samooh kii tulanaa mein reedh aur koolhe key huddy khanij ghanatva mein kramshah 18 pratishat aur 6 pratishat kii vriddhi kii. ack charan III pareekshan mein, rajonivritti key baad mahilaaon mein romozumab upchaar key ack varsh ney placebo samooh kii tulanaa mein kasheruki fracture key jokhim koo cumm curr diyaa. isane placebo samooh kii tulanaa mein cutty merudand (13.3% banaam 0.0%), femoral gardan (5.2% banaam-0.7%) aur kull koolhe (6.8% banaam 0.0%) mein huddy khanij ghanatva mein bhee vriddhi kii. pratikool ghatnaaon koo samoohon key beach santulit kiya gayaa thaa. dunt chikitsa aur punaryoji ranneetiyon key kshetra mein sclerostein kaa mahatva haye joe sclerostein koo lakshit karane key liye vikas mein hain. aprail 2019 mein, khaadya aur dawa prashaasan ney austeoporotic fracture key bahut adhik jokhim vaali mahilaaon mein upayog key liye romozumab koo manjuri dee. ise 2019 mein japan aur europeeya sangh mein upayog key liye bhee manjuri dee gaee thee.

