
dopamine parikalpana

mastishk mein ack atee sakriya aur pareshan dopaminergic sanket pargaman kii ghatana key liye dopamine parikalpana. yeh siddhant chikitsa neuroimaging mein tippaniyon aur kuchh manovikriti-rodhi kii anubhavjanya pratikriya aur dopamine receptor parr unake virodhi prabhaavon seey praapt hotaa haye. haalaanki, yeh ruprekha banaana mahatvapurna haye kii parikalpana atyadhik dopaminergic gatividhi koo hakalaane kaa pratyaksh kaaran naheen maanati haye; isake bajaay, yeh synaptic disregulation ack badey vikaar kaa lakshan haye joe anya mastishk maargon aur sanrachanaon koo prabhaavit kartaa haye.
parichay.
hakalaane vaale aur naa-hakalaane vaale vaktaaon key mastishk imaging key tulanaatmak vishleshan key baad, joe loga hakalaate hain way mastishk key strattle kshetron mein ack uchch dopaminergic gatividhi pradarshit karate hain. ise ack paltu janwar key adhyayan key dauran floro-ell-dopa kaa upayog karke poorv-sanyugma dopaminergic gatividhi key marker aur mastishk sakriyan pattern key aim. aar. aaee. adhyayan key roop mein varnit kiya gayaa haye. choonki dopamine strattle chayapachaya key avarodhak key roop mein kaary kartaa haye, isaliye strattle hypometabolism koo una logon mein precineptic dopamine key darj kiye gaye staron dwara samajhaaya jaa sakata haye joe niyantran samoohon kii tulanaa mein hakalaate hain. joe loga hakalaate they, unamen bolane seey judey prantstha aur upa-nyayalayiya kshetron mein dopamine punah grahan gatividhi kaafee adhik thee, iss parikalpana kaa samarthan karate hue kii madhyasth aur limbic pranaliyon key bheetar dopaminergic maarg una logon mein maanak seey adhik hoe sakate hain joe hakalaate hain. 
dopamine parikalpana key paksh mein tark.
haloperidol.
vishisht manovikriti-rodhi haloperidol, hakalaane key upchaar parikshanon mein sabse adhik upayog kii jaane vaali dawa rahee haye. dohare-andhe placebo-niyantrit parikshanon mein vastunishth bhaashan upaayon key saath, samooh koo 8 saptah key pareekshan key baad haloperidol praapt karane mein mahatvapurna sudhaar pradarshit huaa. haalaanki, iss pahali peedhi key manovikriti-rodhi kii kaarravaai key tantra ney mahatvapurna dushprabhaav paida kiye joe rogiyon mein sahansheelata koo prabhaavit karate hain aur behtar bhaashan koo banaae rakhate hain joe aavashyak haye kii vishay dawa lete rahein. isake alawa, neuroleptics kaa upayog karane key jokhimon kii poori seema kii sarahana karane seey pahale pareekshan kiya gayaa thaa; extrapyramidal lakshan aur sambhaavit sthaayi tardive diskina jisake parinamswarup abb dawa koo khatarnak aur sambhavatah hakalaane key upchaar mein asman key roop mein yogya banaa sakata haye. heloperidol key kaary tantra koo dhyaan mein rakhate hue joe vishesh roop seey dopamine receptors (dee1, dee5 key liye mook virodhi aur dee2, dee3, dee4 key liye vyutkram agonist key madhyam seey) koo lakshit kartaa haye, anya neuroleptics key saath-saath ack placebo parr isaki prabhavsheelta key vipareet, dopaminergic maarg hakalaane key lakshnon seey sahsambaddh prateet hotaa haye kyonki dawa kuchh hudd taka dopaminergic atee sakriya sthiti koo samanya curr detee haye.
aripiprazole.
eripiprazole kii kriya kaa tarika dopamine receptors (postsyneptic dee2 receptor parr aanshik agonist gatividhi aur precineptic dee2, dee3 aur aanshik roop seey dee4 parr aanshik agonist gatividhi) aur serotonin receptors (5-ht1aeye key aanshik agonist aur 5-ht2aeye key virodhi) key saath apani chayanaatmaktaa mein anya asamanya manovikriti seey alag haye. aisaa maanaa jaataa haye kii dopamine dee2 postsyneptic receptor parr eripiprazole kii mukhya virodhi kaarravaai atyadhik dopaminergic gatividhi koo cumm karati haye aur isaki precineptic dee2 virodhi kaarravaai key madhyam seey dopamine key sanshleshan aur rihaai koo bhee cumm curr sakati haye. isake alawa, maanaa jaataa haye kii seratonin receptor 5-aich. tii. 1aeye parr dawa kii agonist gatividhi mein ack chinta kaa prabhaav hotaa haye, joe cumm samajik chinta vaale rogiyon key liye ack sambhaavit spashteekaran pradaan kartaa haye.
manovikriti-prerit haklana.
isake saath hii, yeh dhyaan rakhna dilchasp haye kii dopamine virodhi koo kuchh vyaktiyon mein hakalaane kaa kaaran bhee bataaya gayaa haye aur bhaashan vikaar koo dawa (abilify) key poorv-vipanan parikshanon key dauran eripiprazole key uchit lekin asamanya dushprabhaav key roop mein varnit kiya gayaa haye. yeh prabhaav aage aniyamit dopaminergic charitra key hakalaane kii pushti kartaa haye.
anya vikritiyon key saath samaantaaen.
motor ticks aur touret syndrome hakalaane key saath mahatvapurna visheshtaon koo saajha karate hain; way sabhi shuru mein bachpan mein prakat hotey hain, mahilaaon kii tulanaa mein adhik purushon koo prabhaavit karate hain, ack vaccing aur ghatate pathyakram kaa paalan karate hain, aur bhaavnaatmak tanaav key tahat teevrata mein vriddhi karate hain. bachchon mein tick vikaaron kaa upchaar eripiprazole key prashaasan key saath kushal rhaa haye, arthaat ekal yaa kaee motor yaa mukhar tick, joe hakalaane key saath samaan tantra koo saajha kartaa haye. yeh dekhate hue kii yeye anya dou sthitiyaan ack hii dawa key prati pratikriya karati prateet hoti hain aur lakshanaatmak samaantaon koo dekhate hue, yeye teen vikaar naa kewal samanya visheshtaon koo saajha karate hain, balki shayed ack bahut hii samaan kaaran bhee hain.

