
germ havaa

hotair (hocks transcript antisense aar. aine. aeye. key liye) gunasutra 12 parr hoxk11 aur hoxk12 key beach sthit ack maanav jeane haye. yeh ack gunasutra parr vyakt aar. aine. aeye. kaa pahala udaaharan haye joe gunasutra 2 parr sthit hoxed cluster posterior jeane key pratilekhan koo prabhaavit kartaa haye. germ havaa kaa anukram aur kaary maanav aur choohe mein alag haye. germ havaa key anukram vishleshan seey pataa chalaa kii yeh standhaariyon mein maujood haye, kharaab sanrakshit anukram aur kaafee sanrakshit sanrachanaaen hain, aur paas key hoxk jeane kii tulanaa mein teji seey vikasit huaa haye. ack baad key adhyayan mein pehchaane gaye germ havaa mein 32 nucleotide lambe samay taka sanrakshit gair-coding tatva (see. aine. ee.) haye jisaki ack samaanroop prati hoxed cluster kshetra (hoxed11 aur hoxed12 key beach sthit) mein haye, joe sujhaav detaa haye kii germ havaa sanrakshit anukram kasheruki kii jarh parr poore genome duplication ghatnaaon seey pahale kii haye. jabaki hoxed cluster key saath sanrakshit anukram 32 nucleotide lamba haye, maanav seey machhali taka sanrakshit germ havaa anukram lagbhag 200 nucleotide lamba haye aur sakriya samvardhak visheshtaon (dwidish pratilekhan, aich3key4meey1 aur aich3key27assie shikhar) dwara chihnit haye.
jeane aur pratilipi aar. aine. aeye. utpaad.
germ havaa vaale jeane mein 6,232 bee. pee. hotaa haye aur 2.2 key. bee. lambe gair-coding aar. aine. aeye. anu koo kootbaddh kartaa haye, joe jeane abhivyakti koo niyantrit kartaa haye. iska srot dee. aine. aeye. ack hoxk jeane samooh key bheetar sthit haye. yeh suz-baarah protein dwara gunasutra 12 seey gunasutra 2 mein sthanantarit kiya jaataa haye.
kaary.
germ havaa kaa 5′ chhor ack polycomb-samooh protein polycomb repressive complexes 2 (pee. aar. see. 2) key saath baatchit kartaa haye aur isake parinamswarup chromatin sthiti koo niyantrit kartaa haye. yeh pee. aar. see. 2 dwara hoxed locus key jeane-silencing key liye aavashyak haye. pee. aar. see. 2 germ havaa-madhyasth pratilekhan silencing key liye dispensable haye. germ havaa kaa 3 'anta histone demethylus lsd1 key saath baatchit kartaa haye.
yeh shareer kii satah parr twacha key epigenetic vibhedan mein ack mahatvapurna kaarak haye. vibhinn shaaririk sthitiyon seey twacha alag haye, ee.jee. palak kii twacha pair key talave kii twacha seey kaafee alag hoti haye.
naidaanik mahatva.
metastatic stun cancer mein germ havaa atyadhik vyakt kii jaati haye. praathamik stun tumour mein abhivyakti kaa uchch star baad key metastasis aur mrityu kaa ack mahatvapurna bhavishyavakta haye. yeh aanshik roop seey meer-331-3 pee key sequestration key madhyam seey harr2 oncogene kii germ havaa-madhyasth atee-abhivyakti key kaaran haye, joe harr2 abhivyakti kaa ack nakaratmak niyaamak haye. koshikaon mein, vishesh roop seey una koshikaon mein joe adhik pee. aar. see. 2 koo vyakt karati hain, germ havaa kii abhivyakti kii roktham seey usa koshika kii aakramak kshamata mein kamee aatee haye. yeh annapranali squamous cell carcinoma mein bhee shamil haye.