
pee. tii. pee. aar. see.

protein tyrosine phosphat, receptor prakaar, see jise ptpc key roop mein bhee jaanaa jaataa haye, ack enzyme haye jise manushyon mein, "ptpc" jeane dwara encode kiya jaataa haye. pee. tii. pee. aar. see. koo see. dee. 45 antigen (see. dee. kaa arth haye vibhedan kaa samooh) key roop mein bhee jaanaa jaataa haye, jise mool roop seey leukocyte samanya antigen (ell. see. aeye.) kahaa jaataa thaa.
kaary.
iss jeane kaa protein utpaad, jise cd45 key roop mein jaanaa jaataa haye, protein tyrosine phosphat (ptp) parivaar kaa ack sadasya haye. pee. tii. pee. sanket anu hain joe koshika vriddhi, vibhedan, mitotic chakr aur oncogenic parivartan sahit vibhinn prakaar kii koshikiya prakriyaon koo niyantrit karate hain. see. dee. 45 mein ack baahya koshikiya kshetra, ack ekal parbhakshi khand aur dou antargrahan utprerak kshetra hotey hain, aur iss prakaar yeh receptor prakaar pee. tii. pee. parivaar seey sambandhit haye.
see. dee. 45 ack prakaar kaa aaee transmembrane protein haye joe sabhi bhinn hematopoetic koshikaon (erythrocytes aur plasma koshikaon koo chhodkar) parr vibhinn isophorm mein maujood hotaa haye. cd45 koo tii-aur bee-cell antigen receptor signalling kaa ack aavashyak niyaamak dikhaaya gayaa haye. yeh yaa tou apane baahya koshikiya kshetra (saha-uttejana kaa ack roop) key madhyam seey pratijan receptor parisaron key ghatakon key saath pratyaksh baatchit key madhyam seey kaary kartaa haye, yaa apane koshika-granthi kshetra key madhyam seey pratijan receptor sanket key liye aavashyak vibhinn aiss. aar. see. parivaar sambandh koo sakriya karke kaary kartaa haye. see. dee. 45 jack kinnesses koo bhee dabaata haye, aur isaliye cytokine receptor signalling key nakaratmak niyaamak key roop mein kaary kartaa haye.
iss jeane key kaee vaikalpik roop seey vibhajit pratilekh roop, joe alag isophorm koo encode karate hain, kii soochana dee gaee haye. cd45 key vibhinn isophorm key khilaf antibody kaa upayog niyamit immunohistochemistry mein pratiraksha koshika prakaron key beach antar karane key saath-saath lymphoma aur carcinoma seey ootakiya vargon key beach antar karane key liye kiya jaataa haye.
isophorm.
cd45 protein parivaar mein kaee sadasya hotey hain joe sabhi ack hii jatil jeane key utpaad hotey hain. iss jeane mein 34 exon hotey hain, joe extracellular aur cytoplasmic domen key saath ack badey paimaane parr protein kaa utpaadan karate hain joe donon asamanya roop seey badey hotey hain. exon 4,5 aur 6 (protein kshetron aeye, bee aur see key anuroop) koo vaikalpik roop seey shoonya, ack, dou yaa sabhi teen exon key sanyojan vaale aathh alag-alag protein utpaadon koo utpann karane key liye vibhajit kiya jaataa haye.
see. dee. 45 kaa badaa baahyakoshikiya kshetra atyadhik glycosylated haye, aur yeye aathh samroop isaki paarshv shrinkhalaon kii sanrachana mein vyaapak bhinnata kii anumati dete hain. isophorm protein key aine-terminal kshetra koo prabhaavit karate hain, joe koshika seey raikhik roop seey baahar nikalata haye aur oh-linked glycan shrinkhalaon koo dhaaran kartaa haye. 
see. dee. 45 isophorm koshika-prakaar aur vibhedan-charan vishisht abhivyakti dikhaate hain, ack aisaa pattern joe standhaariyon mein kaafee achchi tarah seey sanrakshit haye. inn samroopon kaa upayog aksar una markers key roop mein kiya jaataa haye joe vibhinn prakaar kii pratiraksha koshikaon kii pehchaan karate hain aur unamen antar karate hain.
nive tii lymphocytes aamtaur parr see. dee. 45raa key liye sakaratmak hotey hain, jisamen kewal ack protein kshetra shamil hotaa haye. sakriya aur smriti tii lymphocytes see. dee. 45. aar. oh. koo vyakt karate hain, joe sabse chhota see. dee. 45 isophorm haye, jisamen aeye, bee aur see kshetron key teenon kaa abhaav haye. yeh sabse chhota isophorm tii cell sakriyan kii suvidha pradaan kartaa haye.
cd45r (jise cd45rabc key roop mein bhee jaanaa jaataa haye) mein sabhi teen sambhaavit exon hotey hain. yeh sabse lamba protein haye aur tii koshikaon seey alag honey parr 200 kda parr sthanantarit hotaa haye. bee koshikaaen bhaari glycosylation key saath cd45aar koo bhee vyakt karati hain, jisase aanvik vajan 220 kda taka pahunchata haye, isaliye iska naam bee220 (bee koshika 220 kda kaa isophorm) haye.
antahkriyaaen.
pee. tii. pee. aar. see. koo nimn key saath baatchit karate hue dikhaaya gayaa haih
see. dee. 45 koo haal hii mein aich. see. aim. vee. ull11 protein key saath antahkriya karate hue dikhaaya gayaa haye. iss antahkriya key parinamswarup tii koshikaon kaa karyatmak pakshaghat hotaa haye. isake alawa, see. dee. 45 koo prajaati dee adenovirus 19aeye ee 3/49 key protein kaa lakshya dikhaaya gayaa thaa joe enke aur tii koshikaon key sakriyan koo rokta haye.
naidaanik mahatva.
see. dee. 45 ack paine-leukocyte protein haye jisamen tyrosine phosphat gatividhi haye joe hematopoisis mein sanket pargaman key viniyaman mein shamil haye. see. dee. 45. murine aur maanav gair-parivartit hematopoetic koshikaon parr lipid raft key saath collocalise naheen kartaa haye, lekin lipid raft key bheetar see. dee. 45 sthiti koo unake oncogenic parivartan key dauran teevra myeloid leukemia mein sanshodhit kiya jaataa haye. see. dee. 45 aeye. aim. ell. koshikaon parr lipid raft key saath collocalise kartaa haye, joe leukemic koshikaon key prasaar mein shamil jee. aim.-see. aiss. aff. sanket kii teevrata koo badhaane mein yogdan detaa haye.
ack janmajaat marker key roop mein upayog karein.
choohon mein see. dee. 45 key dou pehchaan yogya elil hainh cd45.1 (ly5.1 aitihaasik roop seey) aur cd45.2 (ly5.2 aitihaasik roop seey). maanaa jaataa haye kii inn dou prakaar key cd45 karyatmak roop seey samaan hain. iss prakaar, koshikaon kii pehchaan karane key liye vaigyaanik anusandhaan mein unakaa niyamit roop seey upayog kiya jaataa haye. udaaharan key liye, leukocytes koo ack cd45.1 daataa mouse seey, ack cd45.2 mezban mouse mein sthanantarit kiya jaa sakata haye, aur baad mein unaki cd45.1 kii abhivyakti key kaaran pahachaana jaa sakata haye. iss takneek kaa upayog niyamit roop seey chimera utpann karate samay bhee kiya jaataa haye. ack vaikalpik pranali see. dee. 90 (thoy1) elil kaa upayog haye, jiska upayog cd90.1/cd90.2 pranali kaa upayog cd45.1/cd45.2 pranali key samaan tareeke seey kiya jaataa haye.
2016 mein ack nayaa nock-inn mouse see57bl/6 prishthabhoomi parr ack aadarsh janmajaat tanaav key roop mein utpann kiya gayaa thaa. yeh mouse, jise cd45.1stem mouse kahaa jaataa haye, ekal aadhar jodee dwara c57bl/6 tanaav seey alag hotaa haye jisake parinamswarup ack ekal amino acid parivartan hotaa haye joe anti-cd45.1 aur anti-cd45.2 antibody dwara pratikriyashilta mein antar pradaan kartaa haye. iss prakaar koo pratispardhi asthi majja pratyaropan parakh key liye design kiya gayaa thaa aur pichhale maanak key vipareet, "sjl" mouse, jise aupchaarik roop seey pape boy key roop mein jaanaa jaataa haye, ney poorna samaantaa kaa pradarshan kiya thaa. 

