
heptachlorodibenzo-pee-dioxin

1,2,3,4,6,7,8-heptachlorodibenzo-paira-dioxin (jise aksar 1,2,3,4,6,7,8-hpcd key roop mein sandarbhit kiya jaataa haye) diabenzo-pee-dioxin kaa ack polychlorinated vyutpann haye aur isaliye ise polychlorinated diabenzo-pee-dioxin (pee. see. dee. dee.) key roop mein vargeekrit kiya jaa sakata haye, joe dioxin kaa ack upavarg haye jisamen 75 conginers shamil hain. aich. pee. see. dee. dee. diabenzo-pee-dioxin haye joe 1,2,3,4,6,7 aur 8 kii sthiti mein chlorinyukt hotaa haye. yeh ack polycyclic heterocyclic carbonic yaugik haye, kyonki aich. pee. see. dee. dee. mein kaee chakreeya sanrachanaaen (1,4-dioxin ring dwara judey dou benzene ring) hoti hain jisamen dou alag-alag tatva (carbon aur oxygen) isake ring key sadasya hotey hain. aich. pee. see. dee. kaa aanvik sootra see12aich. see. ell. 7oh. 2 haye aur yeh ack safed-rahit choorn haye, joe paani mein aghulansheel haye.
itihas.
dioxin jyaadaatar audyogik prakriyaon key upa-utpaad hain jaise kii keetnashakon kaa nirmaan, kagaj key goode kaa viranjan yaa apashisht bhasmikaran jaisi dahan prakriyaaen. iska matlab haye kii heptachlorodibenzo-pee-dioxin kaa koee samanya upayog naheen haye. 1998 mein, professor sharon bedder ney tark diyaa kii badee companiyon ney dioxin kii vishaakt samasyaon kii gambhirta koo cumm karane kii koshish kii haye. unhone apane pepper mein apani chinta kaa varnan kiya 'dha dioxin vivaadah schools mein failna'. companiyon ney yeh kahate hue pratikriya dee kii bedder kaa pepper 'bhaya aur bhavna' parr adharit thaa naa kii vigyaan parr.
chayapachaya.
heptachlorodibenzo-pee-dioxin kaa ardh-jeevan 3.6 varsh maanaa jaataa haye. yeh anuman 14 varsheeya ladki seey 28 maheene key antaral key saath ekatra kiye gaye vasaa ootak biopsy key vishleshan parr adharit thaa, joe lagbhag 2-3 saal kii avadhi key liye takniki pentachlorophenol key sampark mein aaee thee. hexachlorodibenzo-pee-dioxin aur octachlorodibenzo-pee-dioxin kaa aadhaa jeevan kramshah 3.5 aur 2 varsh honey kaa anuman thaa.
13 saptah kii avadhi mein choohon mein chlorodibenzo-pee-dioxin key sampark key prabhaavon kii jaanch kii gaee thee. yakrit sanchay kaee jaiv rasayanik maapdandon key parivartanon seey judaa huaa thaa. nimnalikhit parivartanon kii khoj kii gaeeh athoxyresorophine-oh-deethylus gatividhi koo niyantranon parr 40 gunaa badhaa diyaa gayaa thaa; kull cytochrome pee450 samagri doguni hoe gaee aur cumm haemoprotein-koo complexes key liye ghaav mein adhikatam 2 nanometer neeli shift kaa pradarshan kiya gayaa. cytochrome pee450see aur cytochrome pee450dee mein kaafee vriddhi hui, jabaki cytochrome pee450bee kaa star aparivartit thaa. yakrit mein maujood lagbhag sabhi dioxincongeners koo octachlorodibenzo-pee-dioxin dwara darshaaya gayaa thaa, jisamen thodi matra mein heptachlorinated-pee-dioxin thaa.
kaarravaai kaa tantra.
samanya roop seey dioxin receptor seey judane mein saksham hotey hain. yeh koshika protein adhikansh dioxin jaise rasayanon key prabhaavon koo shuru kartaa haye. koshika key protein kaa sateek kaary agyaat haye, lekin protein layabaddh karyon aur anga vikas mein bhoomika nibhaata haye.
jaba ack dioxin koshika mein pravesh kartaa haye aur receptor seey judataa haye, tou ack anya protein, arnkt key saath ack complexes banata haye. yeh heterodymer (joe vaastav mein ack pratilekhan kaarak haye) dee. aine. aeye. seey judataa haye. jatil agyaat jeane koo roque yaa sakriya curr sakata haye.
vishaaktata.
chlorachne, blackheads, sist aur pustule kaa ack munhaase jaisa visfot, heptachlorodibenzo-pee-dioxin seey dooshit pentachlorophenol key sampark mein aaney seey judaa huaa haye. yeh sangathan pahali baar taba banaaya gayaa thaa jaba pentachlorophenol key nirmaan mein kaaryarat vyaktiyon kii jaanch kii gaee thee. yeh paaya gayaa kii pentachlorophenol key saath seedhe sampark seey chlorachne kaa khatra kaafee badh jaataa haye. heptachlorodibenzo-pee-dioxin kii vishaaktata parr adhik maanav adhyayan upalabdh naheen hain. haalaanki, pashu adhyayanon ney gair-maanav vishaaktata key star koo dikhaayah khargosh, maukhik> 5000 milligram/kigra, ell. dee. 50 chuha, maukhik> 5000 milligram/kigra, aur ell. dee. 50 ginny pig, maukhik> 600 yuu. jee./kigra.
heptachlorodibenzo-"pee"-dioxin manushyon key liye isaki carcinogenicity key roop mein vargeekrit naheen kiya jaa sakata haye.
heptachlorodibenzo-"pee"-dioxin key abiothic ksharan kaa anuman lagaaya gayaa haye. heptachlorodibenzo-"pee"-dioxin kii vaashp charan pratikriya key liye darr sthiraank kaa anuman 25 degree celsius parr photochemically utpaadit hydroxyl radical key saath 1.3x10 −12 cu semi/anu-seik honey kaa anuman lagaaya gayaa haye joe 5x105 hydroxyl radical prati cu semi kii vayumandaliya sandrata parr 12.3 dinon key vayumandaliya ardh-jeevan seey mell khaata haye.
pratikool prabhaav.
dioxin yaugikon key liye gyaat pratikool prabhaav (jaisa kii pahale ullekh kiya gayaa haye) carcinogenicity hain. isake alawa, chloroekne, daanton key vikas mein gadbadi aur uchch sandrata parr anya vikasatmak prabhaav aich. pee. see. dee. key pratikool prabhaavon key roop mein jaane jaate hain. swaasthya prabhaavon kii ack bahut hii vistrit shrinkhala haye kyonki tantra kaa genome parr sabhi prakaar key prabhaav hoe sakate hain (kaarravaai kaa tantra dekhein). aich. pee. see. dee. choohon mein fefadon key cancer aur anaemia kaa kaaran banata haye. haalaanki, manushyon parr aise kaee adhyayan naheen hain joe aich. pee. see. dee. dee. key swaasthya jokhim karakon kaa aaklan karate hain. aich. pee. see. dee. dee. anya pee. see. dee. dee. kii tulanaa mein shareer mein parisancharan karane key baad adhik shaktishali prateet hotaa haye, jisase yeh anya pee. see. dee. dee. kii tulanaa mein adhik vishaakt hoe jaataa haye. yeh shayed chloro samoohon key uchch pratisthaapan key saath karna haye. 
samanya taur parr dioxin koo kushalata seey todana mushkil hotaa haye. yeh jaiv sanchay aur paryavaraniya dridhata kaa kaaran banata haye.
jaanvaron parr prabhaav.
immunotoxicity.
aich. pee. see. dee. dee. bhed erythrocytes, ack macrophage aur tii-cell-nirbhar antigen key liye see57bee1/6 choohon kii antibody pratikriya koo dabaane key liye jaanaa jaataa haye. inn vivo drishtikon koo aich. pee. see. dee. dee. key teevra maukhik sampark dwara see57bee1/6 choohon kii antibody pratikriya key daman kii samvedansheelta koo chihnit karane key liye lagu kiya gayaa haye. antigen chunauti seey pahale yaa usake baad vibhinn samay parr aich. pee. see. dee. dee. prashaasan key baad antibody pratikriya kaa daman dekhaa gayaa thaa.
carcinogenicity.
aich. pee. see. dee. koo mahila (aur kewal mahila) choohon mein ack shaktishali yakrit tumour pravartak key roop mein ingit kiya jaataa haye. mahila choohon key hepatocytes kii praathamik sanskritiyon mein, aich. pee. see. dee. dee. aur cozner kii saha-mitogenic kriyaon koo eril-hydrocarbon (aeye. aich.) receptor dwara madhyasthata kii jaati haye. inn kriyaon koo astrogen dwara badhaaya jaataa haye. mahila choohon key yakrit mein tumour key prachaar mein akele aich. pee. see. dee. dee. apekshaakrit aprabhaavi haye, lekin jaba dee. aine. aeye.-sanshleshan epidermal vikas kaarak dwara uttejit hotaa haye, tou aich. pee. see. dee. dee. ack saha-mitogen key roop mein kaary kartaa haye. yeye prabhaav polychlorinated diabenzo-pee-dioxin key vibhinn congeneres key liye dekhe jaate hain, joe eril-hydrocarbon receptor key saath unake sambandh key aadhar parr hotey hain.