asbutolol

asbutolol, joe anya key beach brand naam sectral key tahat becha jaataa haye, uchch raktchaap aur ataalata key ilaaj key liye ack beeta avarodhak haye. asbutolol ack cardioselective beeta-1 blocker haye aur isamen aantarik sahaanubhooti gatividhi hoti haye. iska upayog aamtaur parr enzyna key upchaar mein kiya jaataa haye. 
ise 1967 mein patent karaaya gayaa thaa aur 1973 mein chikitsa upayog key liye anumodit kiya gayaa thaa.
dushprabhaav.
asbutolol key saath upchaar key tahat 10 seey 30 pratishat rogiyon mein anty-nuclear antibody (aeye. aine. aeye.) kaa vikas paaya gayaa haye. 1 pratishat mein gathiya dard aur mayalgia key saath ack pranaaleegat bimari dekhi gaee haye. twacha parr chakatte aur multiform anga kii bhagidari key saath ack lupus erythematosus-jaisa syndrome aur bhee cumm hotaa haye. asbutolol key tahat enaa aur rogsoochak roga donon kii ghatana propranolol key tahat kii tulanaa mein adhik hoti haye. purush rogiyon kii tulanaa mein mahila rogiyon mein inn lakshnon key vikasit honey kii sambhavana adhik hoti haye. yakrit enzymon (aeye. ell. tii., aeye. aiss. tii.) mein vriddhi key saath hepatotoxicity key kuchh mamle dekhe gaye hain. kull milakar, ilaaj kiye gaye sabhi rogiyon mein seey 5 seey 6 pratishat koo asahaniya dushprabhavon key kaaran asbutolol koo bund karna padata haye. jaba sambhav hoe, tou upchaar koo dheere-dheere bund curr diyaa jaanaa chaahiye taaki enzyna kii badhati aavritti aur yahaan taka kii myocardial inforction kii varsha key saath ack vaapsee syndrome seey bachaa jaa sakey.
pharmacology.
asbutolol ack cardioselective beeta-1 blocker haye jise apani aantarik sahaanubhooti gatividhi (aaee. aiss. aeye.) key kaaran aanshik agonist bhee maanaa jaataa haye. iska matlab haye kii yeh aaraam mein nimn-shreni beeta uttejana pradaan kartaa haye lekin sahaanubhooti gatividhi adhik honey parr vishisht beeta-blockers key roop mein kaary kartaa haye. beeta-blocker varg kii anya davaaon key beach, asbutolol cumm hudd taka beeta-blockade prabhaav pradaan karega. apani cardioselectivity key kaaran, asbutolol asthama yaa chronic obstructive pulmonary digies (copd) vaale rogi mein gair-cardioselective beeta-blockers kii tulanaa mein adhik upayukt haye, jise beeta-blocker key saath upchaar kii aavashyakta hoti haye. yeh hriday-vishishtata uchch raktchaap-rodhi prabhaavon koo cumm curr degi jaisa kii propenalol aur nadolol jaise gair-vishisht beeta blockers key saath dekhaa jaataa haye. (inn karanon seey, yeh polypill ranneetiyon mein shamil karane mein pasand kaa beeta-blocker hoe sakata haye). pratidin 800 milligram seey cumm khuraak mein, propranolol upchaar key tahat dekhe gaye logon mein seey kewal 10 seey 30 pratishat bronchial system aur chikani maanspeshiyon parr isake sankuchan prabhaav hotey hain, lekin prayogaatmak pramaan hain kii cardioselective guna 800 milligram/dinn yaa usase adhik kii khuraak parr cumm hoe jaate hain.
dawa mein lipophilic guna hotey hain aur isaliye yeh rakt-mastishk baadha koo paar karati haye. asbutolol kaa seeram lipid (collestroll aur triglycerides) parr koee nakaratmak prabhaav naheen padata haye. aich. dee. ell. mein koee kamee naheen dekhi gaee haye. iss sambandh mein, yeh kaee anya beeta-blockers key vipareet haye jinamen yeh pratikool guna haye.
dawa uchch raktchaap vaale rogiyon mein uchch, samanya yaa cumm renin plasma sandrata key saath kaam karati haye, halanki uchch yaa samanya renin plasma sandrata vaale rogiyon mein asbutolol adhik kushal hoe sakata haye. chikitsakiya roop seey praasangik sandrata mein, ack jhilli-sthir prabhaav ack mahatvapurna bhoomika nibhaata prateet naheen hotaa haye.
pharmacokinetics.
asbutolol jee. aaee. maarg seey achchi tarah seey avashoshit hotaa haye, lekin paryaapt first-paas-metabolisation seey gujarta haye, jisase kewal 35 pratishat seey 50 pratishat kii jaiv upalabdhata hoti haye. maukhik khuraak key baad 2 seey 2.5 ghante key bheetar asbutolol kaa charam plasma star pahunch jaataa haye. mukhya sakriya chayapachaya, diacetolol kaa charam star 4 ghante key baad pahunch jaataa haye. asbutolol kaa aadhaa jeevan 3 seey 4 ghante kaa hotaa haye, aur diacetolol kaa aadhaa jeevan 8 seey 13 ghante kaa hotaa haye.
asbutolol vyaapak yakrit chayapachaya seey gujarta haye jisake parinamswarup desbutile amine acetolol hotaa haye joe aasaani seey diacetolol mein parivartit hoe jaataa haye. diacetolol asbutolol (samatulyata) key roop mein sakriya haye aur aisaa prateet hotaa haye kii iska aushadhiya roop ack hii haye. jarachikitsa rogiyon mein asbutolol aur diacetolol donon kaa uchch star kaa plasma star hotaa haye aur thodaa lamba utsarjan hotaa haye. gurde kii haani vaale rogiyon mein utsarjan kaafee lamba hotaa haye, aur isaliye khuraak mein kamee kii aavashyakta hoe sakati haye. yakrit serosis mool dawa aur chayapachaya key pharmacokinetic profile koo naheen badalata haye.

