paas domen

ack prati-gyaan-sima (paas) kshetra jeevan key sabhi raajyon mein paaya jaane vaalaa ack protein kshetra haye. aam taur parr, paas domen ack aanvik samvedak key roop mein kaary kartaa haye, jisake madhyam seey chhote anu aur anya protein paas domen key bandhan key madhyam seey judate hain. iss samvedan kshamata key kaaran, paas domen koo circadian ghadee key protein-protein antahkriya mein shamil pramukh sanrachanaatmak rupankan key roop mein dikhaaya gayaa haye, aur yeh sanket protein mein paaya jaane vaalaa ack samanya rupankan bhee haye, jahaan yeh ack sanket samvedak key roop mein kaary kartaa haye.
khoj.
paas domen bacteria seey laker standhaariyon taka badee sankhya mein jeevon mein paae jaate hain. paas domen kaa naam una teen proteins key naam parr rakhaa gayaa thaa jinamen isaki pahali baar khoj kii gaee theeh
paas domen kii praarambhik khoj key baad seey, bacteria aur eukariotes mein badee matra mein paas domen binding saiton kii khoj kii gaee haye. paas lava protein naamak ack upasamuchchay oxygen, prakaash aur voltage key liye uttardaayi hotaa haye.
sanrachana.
halanki paas domen anukram parivartansheelta kii ack degree pradarshit kartaa haye, paas domen core kii tri-ayami sanrachana vyaapak roop seey sanrakshit haye. iss core mein paanch-fanse antiparal beeta-sheet aur kaee α-hellis hotey hain. sanket key parinamswarup sanrachanaatmak parivartan, mukhya roop seey β-patrak key bheetar utpann hotey hain. yeye sanket core key α-hellis key madhyam seey sahsanyojak-sanlagn prabhaavak kshetra mein failate hain. 1998 mein, paas domen core vastukala koo pahali baar "helorhodospira helophila" seey photoactive peele protein (pee. aaee. pee.) kii sanrachana mein darshaaya gayaa thaa. kaee proteins mein, paas domen kaa ack diamer aavashyak hotaa haye, jisake dwara ack ligand koo baandhata haye aur doosara anya proteins key saath baatchit kartaa haye.
jeevon mein paas key udaaharan.
gyaat paas domen 20 pratishat seey cumm ausat yugm-vaar anukram pehchaan saajha karate hain, jiska arth haye kii way aashcharyajanak roop seey bhinn hain. paas domen aksar anya paryaavaran samvedi tantra key saath protein parr paae jaate hain. saath hii, kaee paas domen photoreceptive koshikaon seey judey hotey hain.
bacteria.
aksar jeevaanu samrajya mein, paas domen sanket protein key emino terminus jaise samvedak hystidine kinnes, chakreeya-dee-jee. aim. pee. sanshleshan aur hydroless aur methyl-grahan karane vaale chemotaxis protein parr sthit hotey hain.
"neurospora.
prakaash kii upasthiti mein, safed collar-1 (doubleu. see.-1) aur safed collar-2 (doubleu. see.-2) paas domen dwara madhyasthata key madhyam seey demarise karate hain, joe aff. aar. kyu. key anuvaad koo sakriya kartaa haye.
"drosophila.
prakaash kii upasthiti mein, see. ell. key. aur see. see. ack paas domen key madhyam seey sanlagn hotey hain, prati key anuvaad koo sakriya karate hain, joe phir prati paas domen key madhyam seey samay koo jodata haye. 
nimnalikhit jeane mein paas binding domen hotey hainh prati, samay, cluck, sike.
"arabidopsis.
ack paas domen jdtl aur aur jeane mein paaya jaataa haye. yeye kshetra "neurospora" circadian-sambaddh protein doubleu. see.-1 mein paae jaane vaale paas kshetra key samaan hain.
standhari.
vartamaan mein standhaariyon key liye samajhi jaane vaali circadian ghadee taba shuru hoti haye jaba prakaash apane paas domen key madhyam seey baandhane key liye bee. aim. ell. 1 aur clake koo sakriya kartaa haye. vaha sakriyak parisar prati 1, prati 2 aur prati 3 koo niyantrit kartaa haye, jinamen sabhi paas domen hain joe cryptochrome 1 aur 2 (cry 1,2 parivaar) seey judane key liye upayog kiye jaate hain. nimnalikhit standhari jeane mein paas binding domen hotey hainh prati 1, prati 2, prati 3, cry 1, cry 2, bamal, clake, passed 1.
anya standhari bhoomikaaen.
standhaariyon key bheetar, donon paas kshetra mahatvapurna bhoomika nibhaate hain. paas aeye anya paas domen protein key saath protein-protein antahkriya key liye jimmedaar haye, jabaki paas bee kii adhik bahumukhi bhoomika haye. yeh chapronin aur anya chhote anuon jaise dioxin key saath baatchit kaa madhyasthata kartaa haye, lekin aine. pee. aeye. aiss. 2 mein paas bee domen, drosophila cluck jeane kaa ack samroopata, aur hypoxia inducible factor (aich. aaee. aff.) bhee ligand binding mein madhyasthata karane mein madad kartaa haye. isake alawa, aine. pee. aeye. aiss. 2 protein vaale paas domen koo utparivarti choohon mein ghadee jeane kaa vikalp dikhaaya gayaa haye, jinamen ghadee jeane kii poori tarah seey kamee haye.
paas domen bhee seedhe bee. aich. ell. aich. key saath baatchit kartaa haye. yeh aamtaur parr bee. aich. ell. aich. protein key see-terminus parr sthit hotaa haye. bee. aich. ell. aich. protein vaale paas domen ack bee. aich. ell. aich.-paas protein banaate hain, joe aamtaur parr aich. aaee. aff. mein paaya jaataa haye aur encode kiya jaataa haye, jisake liye paas domen aur bee. aich. ell. aich. domen aur ghadee jeane donon kii aavashyakta hoti haye.

