
aine. dee. aff. aeye. 5

naadh dehydrogenase [ubquinone] 1 alfa subcomplexes subunit 5 ack enzyme haye jise manushyon mein "endufa5" jeane dwara kootbaddh kiya jaataa haye. endufa5 protein naadh dehydrogenase (ubquinone) kii ack upa-ikai haye, joe mitochondrial aantarik jhilli mein sthit haye aur electron parivahan shrinkhala key paanch parisaron mein seey sabse badaa haye.
sanrachana.
endufa5 jeane gunasutra 7 kii kyu bhuja parr sthit haye aur yeh 64,655 aadhar jode mein faila huaa haye. jeane 116 amino acid seey banaa 13.5 kilo dee. aeye. protein paida kartaa haye. endufa5 enzyme naadh dehydrogenase (ubquinone) kii ack upa-ikai haye, joe shwasan parisaron mein sabse badaa haye. sanrachana ack lambe, hydrophobic transmembrane domen key saath ell-aakar kii haye aur paridhiya bhuja key liye ack hydrophilic domen haye jisamen sabhi gyaat redox kendra aur naadh binding site shamil hain. yeh dhyaan diyaa gayaa haye kii aine-terminal hydrophobic domen mein ack see-terminal hydrophilic domen key saath aantarik mitochondrial jhilli mein faile ack alfa helix mein modane kii kshamata haye joe complexes i kii golakar upa ikaaiyon key saath baatchit kartaa haye. atyadhik sanrakshit dou-domen sanrachana seey pataa chalata haye kii yeh visheshta protein kaary key liye mahatvapurna haye aur hydrophobic domen aantarik mitochondrial jhilli mein naadh dehydrogenase (ubquinone) parisar key liye ack lunger key roop mein kaary kartaa haye. endufa5 lagbhag 31 hydrophobic upa ikaaiyon mein seey ack haye joe complexes i key transmembrane kshetra kaa nirmaan karati haye. protein jatil i key 7 ghatak yukt, paani mein ghulansheel lauh-sulfur protein (ips) ansh key hisse key roop mein aantarik mitochondrial jhilli mein sthaaniyakrit hotaa haye, halanki isaki vishisht bhoomika agyaat haye. maanaa jaataa haye kii yeh initiator methionine key anuvaad key baad key nishkasana aur agale amino acid key aine-acetylation seey gujarta haye. anumaanit dwiteeyak sanrachana mukhya roop seey alfa helix haye, lekin protein key carboxy-terminal aadhe mein kundalit-kundal roop koo apanaane kii uchch kshamata haye. amino-terminal bhaag mein hydrophobic amino acid seey bharpur ack anumaanit beeta sheet hoti haye joe mitochondrial ayaat sanket key roop mein kaam curr sakati haye. chaar anya gunasutron parr bhee sambandhit chhadmajanakon kii pehchaan kii gaee haye.
kaary.
shwasan shrinkhala key jatil i kii b13 upa-ikai key liye maanav ndufa5 jeane code, joe electrons koo nadh seey ubiquinone mein sthanantarit kartaa haye. endufa5 protein mitochondrial aantarik jhilli mein sthaaniyakrit hotaa haye aur aisaa maanaa jaataa haye kii yeh electrons key iss hastaantaran mein sahaayata kartaa haye. shuru mein, naad jatil i seey judataa haye aur dou electrons koo flavin mononucleotide (aff. aim. aine.) kritrim bhuja key isoaloxazine ring mein sthanantarit kartaa haye taaki aff. aim. aine. aich. 2 bunn sakey. electrons koo kritrim bhuja mein lauh-sulfur (aff. ee.-aiss.) samoohon kii ack shrinkhala key madhyam seey aur anta mein saha-enzyme kyu10 (see. oh. kyu.) mein sthanantarit kiya jaataa haye, joe ubquinol (see. oh. kyu. aich. 2) mein cumm hoe jaataa haye. electrons kaa pravaah protein kii redox sthiti koo badal detaa haye, jisake parinamswarup ack sanrachanaatmak parivartan hotaa haye aur aayaneekaran yogya paarshv shrinkhala kaa pee "key" sthanantaran hotaa haye, joe mitochondrial matricks seey chaar hydrogen ayanon koo baahar nikaalata haye. paudhon aur kavak taka faile hue endufa5 key sanrakshan kaa uchch star enzyme parisar mein isake karyatmak mahatva koo ingit kartaa haye.
naidaanik mahatva.
aine. dee. yuu. aff. aeye. 5, aeye. tii. pee. 5aeye. 1 aur aeye. tii. pee. 5aeye. 1 sabhi autism rogiyon key mastishk mein lagaatar cumm abhivyakti dikhaate hain. mitochondrial disfunction aur bigade hue atp sanshleshan key parinamswarup oxidative tanaav hoe sakata haye, joe autism key vikas mein bhoomika nibha sakata haye.
antahkriyaaen.
endufa5 mein kaee protein-protein antahkriyaaen hoti hain, jaise kii ubquitin see aur endufby1, endufby9 aur endufby10 sahit naadh dehydrogenase [ubquinone] 1 beeta subcomplexes key sadasyon key saath.

