
plakeg2

plextrin homology domen jisamen parivaar jee sadasya 2 (plakeg 2) hotaa haye, ack protein haye jise manushyon mein "plakeg 2" jeane dwara kootbaddh kiya jaataa haye. ise kabhi-kabhi arhgef42, flj00018 key roop mein likhaa jaataa haye.
plakeg2 protein lagbhag 1300 emino acid, 130 kda kaa ack vishal protein haye aur isaki sanrachana key aine terminus key paas ack dee. bee. ell. homology (dee. aich.) domen aur ack plextrin homology (pee. aich.) domen haye. dee. aich. domen guanin nucleotide vinimay gatividhi key liye jimmedaar ack domen haye joe row parivaar key chhote gtpage (rhogtpase) parr gdp koo gtp mein parivartit kartaa haye, aur iss domen vaale plekhag 2 ack row-vishisht guanin nucleotide vinimay kaarak (rhogef) key roop mein bhee kaary kartaa haye.
rhogtpase key sakriyan seey actin cytoskeleton kaa punargathan hotaa haye aur koshika aakriti vigyaan mein badalaav hotaa haye, isaliye plekhg2, rhogtpase aur actin remodeling (baad mein dekhein) key madhyam seey koshika gatishilata aur neurons key neuronal network key vikas mein yogdan dey sakata haye.
cloning.
retroviral transduction dwara utparivartit punah sanyojak bxh2 aur akxd nasl key choohon koo uchch aavritti parr myeloid leukemia, bee koshika aur tii koshika leukemia vikasit karane key liye jaanaa jaataa haye.
2002 mein, himmel aur anya., teevra milogenous leukemia key iss model kaa upayog kiya aur dikhaaya kii ack nayaa dee. bee. ell. parivaar gwanine nucleotide vinimay kaarak jeane retroviral uptech site key neeche kii or nihit haye jise ev24 kahaa jaataa haye. unhone iss jeane koo see. ell. jee. naam diyaa. hemel aur unake sahyogiyon ney see. ell. jee. kaa pratiroopan kiya aur maanav gunasutra 19 gunasutra 19q13.1 kshetra mein nihit plekh 2 key saath samroopata dikhaai. inn tippaniyon seey unhone teevra myeloid leukemia key saath sambandh kii or ishara kiya.
kaary.
hemel aitt all dwara prakaashit ack pepper mein.2002 mein, unhone dikhaaya kii see. ell. jee. key dee. aich. aff. domen vaalaa ack nirmaan see. dee. see. 42 key guanin nucleotide vinimay koo badhaava detaa haye, lekin rack 1 yaa roa key guanin nucleotide vinimay koo badhaava naheen detaa haye. isake alawa, dee. aich.-aff. domen yaa poorna-lambai vaale see. ell. jee. koo nih3tii3 koshikaon mein pesh kiya gayaa aur parivartan huaa.
baad mein, ueda aur unake sahyogiyon ney poorna-lambai vaale maanav plake 2 key abhivyakti nirmaan koo heck 293 koshikaon mein pesh kiya. iss koshika mein trimeric jee protein key gbtg upa-ikai seedhe plekh 2 key saath baatchit kii gaee thee. ueda aur sahyogiyon ney yeh bhee dikhaaya kii plekh 2 koo jee. bee. jee. dwara sakriya kiya gayaa thaa aur plekh 2 ract 1, see. dee. see. 42 koo sakriya kartaa haye aur koshika roopaatmak parivartan mein yogdan detaa haye.
2013 mein, ranane aur anya., yeh dikhaaya kii pleekh 2 kaee leukemia koshika rekhaaon mein oonchaa haye, jisamen jurkat tii koshikaaen bhee shamil hain. isake alawa, unhone dikhaaya kii jee. pee. see. aar. sanket-nirbhar rack aur see. dee. see. 42 kaa sakriyan actin polymerisation key madhyam seey lymphocytes key chemotaxis koo niyantrit kartaa haye. iss avalokan seey pleekh 2 koo koshika gatishilata kaa ack mahatvapurna niyaamak maanaa jaataa thaa.
isake alawa, haal key varshon mein, yeh spasht hoe gayaa haye kii plekh 2 phosphorylation jaise sanshodhan aur vibhinn antahkoshikiya sanketon dwara anya proteins key saath baatchit key madhyam seey viniyaman seey gujarta haye (baatchit/protein sanshodhan parr khand dekhein). haalaanki, vivo mein kaary abhee bhee spasht naheen haye.
pleekhag2 seey sambandhit roga.
2016 mein, adversion aur anya., dystonia yaa prasavottar microcephaly key rogiyon mein plekh 2 jeane mein aarg204trp utparivartan key liye samroopata kii pehchaan kii gaee.
antahkriyaaen.
plekhag2 nimnalikhit proteins key saath antahkriya karane key liye jaanaa jaataa haye.
β γ
β-actin
saadhe chaar lima domen 1 (aff. aich. ell. 1)
jee. aeye. aiss
protein sanshodhan.
yeh gyaat haye kii plekhag2 nimnalikhit sanketon dwara phosphorylation jaise sanshodhan seey gujarta haye.
aiss. aar. see.
égfr

