
cytokine vitaran pranali

cytokine polypeptide yaa glycoprotein hotey hain joe pratiraksha koshikaon koo vibhinn prakaar kii koshikaon mein prasaar, sakriyan, vibhedan aur soojan yaa virodhi-soojan sanketon koo prerit karane key liye ack dusare seey samvaad karane mein madad karate hain. 2000 key baad seey antitumer upchaar key liye cytokine kaa upayog karane vaale adhyayanon mein kaafee vriddhi hui haye, aur vibhinn cytokine advitiya antitumer gatividhiyaan pradaan karate hain. cytokine jyaadaatar antiproliferative yaa proapoptotic maargon key madhyam seey tumour koshika key vikas mein baadha daalate hain, lekin tumour koshikaon key khilaf cytotoxic prabhaav rakhane key liye pratiraksha koshikaon koo ujagar karke apratyaksh roop seey vikas koo baadhit curr sakate hain. bhale hii aff. dee. aeye.-anumodit cytokine upchaar hain, cytokine vitaran seey judee dou mukhya samasyaaen hain. pahala yeh haye kii cytokins kaa aadhaa jeevan cumm hotaa haye, isaliye chikitsiya prabhaav key liye uchch khuraak kaa baar-baar sevan aavashyak haye. doosara yeh haye kii pranaaleegat vishaaktata hoe sakati haye yadi cytokine vitarit ack teevra pratiraksha pratikriya kaa kaaran banati haye, jise cytokine toofaan key roop mein jaanaa jaataa haye.
pagillated cytokins.
pagillation protein key liye polyethylene glycol (pegg) koo sahsanyojak roop seey baandhane kii prakriya haye. pagillation baadhya protein key aadhe jeevan koo badhaata haye, jisase nirantar vitaran hotaa haye. yeh fayademand haye kyonki rogi mein samaan chikitsiya prabhaav key liye cumm, cumm baar khuraak kii aavashyakta hogi, joe prasav pranali kii cytotoxicity koo seemit curr dega. pegfilgrastim iss vitaran pranali kaa ack safal udaaharan haye. pegfilgrastim granulocyte-coloney uttejak kaarak (jee-see. aiss. aff.) filgrastim kaa pagillated roop haye. pegfilgrastim una rogiyon mein neutrophil key utpaadan aur rihaai koo uttejit kartaa haye joe myelospressive anticancer davaaon yaa vikiran praapt karane key baad asthi majja vishaaktata kaa anubhav karate hain. filgrastim kaa aadhaa jeevan 3-4 ghante kaa hotaa haye, jabaki pegfilgrastim kaa aadhaa jeevan 45 ghante kaa hotaa haye. yeh rogiyon key liye bahut adhik suvidhajanak haye, kyonki unhein lambe samay taka filgrastim kii kaee khuraakon key bajaay kewal ack khuraak kii aavashyakta hogi. siliyari neurotrophic factor (see. aine. tii. aff.) ack cytokine haye jiska upayog madhumeh key lakshnon jaise bhookh mein kamee aur vajan ghataane seey nipatane key liye kiya jaataa haye. see. aine. tii. aff. key ack pagilated sanskaran ney vitro mein javic gatividhi koo banaae rakhaa aur pharmacokinetics koo badhaaya. pagillated see. aine. tii. aff. ney aahar-prerit motey jaanvaron mein glycemia koo bhee cumm curr diyaa, jisamen ack khuraak aparivartit see. aine. tii. aff. seey 10 gunaa adhik thee. inn adhyayanon seey pataa chalata haye kii pagillated cytokins kaa upayog cytokins key nirantar vitaran key liye kiya jaa sakata haye, jisase inn upchaaron kii chikitsiya khidki badh jaati haye.
pagillation key kaaran honey vaali ack pramukh samasya yeh haye kii cytokine apane aanvik sanrachana, gatividhi aur jaiv upalabdhata koo pegg binding parr badal sakata haye. cytokine apane chhote aakar key kaaran fayademand hotey hain, joe unhein antahkoshikiya lakshyon taka pahunchane kii anumati dete hain. cytokine key liye pegg binding unhein apane vishisht lakshyon taka pahunchane key liye bahut bhaari banaa sakati haye, jise pagillated cytokine koo design karate samay dhyaan mein rakhaa jaanaa chaahiye.
gagg-adharit jaiv samagri.
glycosaminoglycane (gags) praakritik roop seey diasecharides key alag-alag anukramon key saath polysaccharides seey praapt hotey hain. gags cytokines seey judate hain aur cytokines koo extracellular matricks taka pahunchaakar koshika bharti, soojan aur ootak punarnirmaan koo niyantrit karate hain. binding adhyayanon seey pataa chalata haye kii gags mein cytokins key liye ack praakritik sambandh hotaa haye, aur cytokins key liye cytokins binding cytokins parr sakaratmak roop seey charge kiye gaye domen aur nakaratmak roop seey charge kiye gaye sulfate aur carboxylic acid avasheshon key beach gair-vishisht electrostatic baatchit dwara madhyasthata kii jaati haye. cytokine vitaran key liye gagg heprin kaa vyaapak roop seey anveshan kiya gayaa haye. heprin-adharit hydrogel 2 saptah seey adhik samay taka il-4 kii nirantar delivery pradaan karate hain, jisase akele il-4 kii tulanaa mein adhik virodhi-soojan pratikriya hoti haye. ack anya adhyayan ney samvahani endothelial vriddhi kaarak (vee. jee. aff.) aur fibroblast vriddhi kaarak (aff. jee. aff.-2) dene key liye ack starpeg-heprin hydrogel pranali kaa upayog kiya. heprin kii badee sandrata ney cytokine koo ack dusare seey swatantra honey kii anumati dee. hydrogel seey cytokine kii code delivery ney inn vitro aur inn vivo donon mein pro-angiogenic prabhaav paida kiye, jiska prabhaav ekal vikas karakon key prashaasan seey bahut adhik thaa.
immunocytokines.
pratirakshi sanyugman cytokine vitaran key liye ack aur ashajanak vidhi haye. cytokine key prati antibody sanyugman kaa upayog site-vishisht vitaran mein sudhaar karane aur cytokine key aadhe jeevan koo badhaane key liye kiya jaa sakata haye. immunocytokin pranalibaddh roop seey vitarit kiye jaate hain lekin vishesh roop seey adhik abhivyakt yaa advitiya tumour antigen, kewal tumour mein paae jaane vaale gupt baahya koshikiya matricks epitope, yaa tumour angiogenesis kaa sanket dene vaale neovasculature marker key madhyam seey tumour koo lakshit curr sakate hain. sergutuzumab amunalekin (see. ee. aeye.-aaee. ell. vee.) ack antibody-cytokine sanyugma haye joe cytokine-aaee. ell.-2 koo carcinoembronic antigen (see. ee. aeye.) koo lakshit karane vaale antibody key saath jodata haye. yeh sanyugma adhimaantah tumour sookshm vatavaran koo lakshit kartaa haye taaki sthaaniya vitaran mein vriddhi hoe sakey aur lakshya seey baahar vishaaktata koo cumm kiya jaa sakey. see. ee. aeye.-aaee. ell. 2. vee. see. ee. aeye. koo vyakt karane vaali thhos ghaatak sthitiyon key ilaaj mein charan I naidaanik pareekshan chala rhaa haye. ack anya immunocytokin habsi1-il12 haye, jise fibronectin key aid-bee domen koo lakshit karane key liye vikasit kiya gayaa thaa. yeh kshetra tumour ootakon mein atee-abhivyakt haye lekin lagbhag sabhi samanya vayask ootakon mein agyaat haye. habsi1-il12 key pranaaleegat prashaasan ney prayogaatmak pc3 metastes koo samaapt curr diyaa aur akele il-12 kii tulanaa mein pratirakshaatmak choohe mein kaee maanav tumour lines key vikas koo adhik prabhaavi dhang seey dabaa diyaa. ack charan I pareekshan ney gurde key carcinoma aur ghaatak melanoma rogiyon mein hubbs1-il12 key saptahik jalsek kii suraksha kaa adhyayan kiya. adhikatam sahan kii jaane vaali khuraak 15 yuu. jee./kii. graa. paaee gaee, joe akele aaee. ell.-12 kii adhikatam sahan kii jaane vaali khuraak seey 30 gunaa adhik haye.
pranaaleegat roop seey prashaasit immunocytokin seey cytokine seey sambandhit cytotoxicity mein kaafee kamee aaney kii sambhavana haye, lekin ise samaapt naheen kiya jaa sakata haye. immunocytokine abhee bhee pratiraksha koshikaon key saath baatchit karate hain taaki tumour key baahar sanket koo prerit kiya jaa sakey, aur gair-lakshit ootakon mein gair-vishisht bandhan key saath samasyaaen hain joe shareer mein niyamit pratiraksha karyon koo baadhit curr sakati hain. choonki immunocytokin shareer key liye videshi hain, way ack pratiraksha pratikriya kaa kaaran bhee bunn sakate hain joe anty-immunocytokin antibody kaa utpaadan kartaa haye jisase aushadhiya unmoolan, chikitsiya parivartan yaa atisamvedansheelta pratikriyaen hoti hain.
gair-vishaanujanit nainokan.
nainokan vitaran pranaaliyan jaiv sakriyata koo prabhaavit kiye binaa yaugikon koo samaahit karane kii unaki kshamata key kaaran lokpriya hain, aur way lakshit ootakon key liye sannihit yaugikon key niyantrit aur nirantar release kaa pradarshan karate hain. nainokanon koo carbonic yaa acarbonic agents seey banaaya jaa sakata haye aur unamen cytokine koo "inn vivo" mein sthir karane kii kshamata hoti haye, lakshya sthal parr gatividhi koo badhaata haye, jaleey ghulansheelata mein sudhaar kartaa haye, aur pranaaleegat vishaaktata koo cumm kartaa haye. vilaayak, ph, tapman, avesh aur aakar kaee mapdand hain joe aavaran dakshata, nainokan vishaaktata aur cytokine sthirata koo prabhaavit karate hain. cytokine koo unake vitaran key liye encapsulated, adhishoshit yaa nainokan pranaliyon mein sanyugmit kiya jaa sakata haye, aur kaee nainokan pranaaliyan hain jinka upayog cytokine vitaran key liye kiya jaa sakata haye.
polymeric nanoparticles jaiv sangat hotey hain, cumm vishaaktata vaale hotey hain aur jaiv apghataniya hotey hain. inca upayog anya nainokan pranaliyon kii tulanaa mein parisancharan samay, sthirata aur aavaran kshamata mein sudhaar key liye kiya jaa sakata haye. polylactic-koo-glycolic acid (pee. ell. jee. aeye.) nainokan vitaran pranaliyon key liye sabse lokpriya bahulak haye, kyonki tail-inn-watter vidhi, uchch sthirata, hydrophobic aur hydrophilic anuon donon key aasaan avashoshan yaa avashoshan kaa upayog karke isake saral sanshleshan key kaaran, aur satah mein aasaan sanshodhan. unnat atherosclerosis ghaavon mein pattika key gathan koo rokane key liye il-10 koo gherne vaale pee. ell. jee.-pegg nanoparticles banaae gaye they. il-10 key saath behtar sthir vidyut sampark key liye isake antim bhaagon mein pee. ell. jee. aeye. koo charge kiya gayaa thaa, jabaki paig kaa upayog nainokan koo karyatmak banaane key liye kiya gayaa thaa. inn pluga-pegg-ill-10 nanoparticles ney adhik sthirata aur lambe samay taka ill-10 key pranaaleegat parisancharan kii anumati dee aur koee bhee inn vitro yaa inn vivo cytotoxicity naheen dikhaai.
liposome ack anya prakaar kii nainokan vitaran pranali haye jiska vyaapak roop seey adhyayan kiya jaataa haye. liposome aasaani seey lipid dwistariya aur koshika jhilli koo paar curr sakate hain lekin aamtaur parr vivo mein teji seey samaapt hoe jaate hain jaba taka kii khoonti yaa kissy anya bahulak key saath sthir naa hoe jaae. liposome kaa gathan bhee samasyaaen prastut curr sakata haye, kyonki vishaakt solvents, uchch tapman aur cumm ph nainokanon kii jaiv suraksha koo cumm curr sakate hain yaa cytokine koo vikrit curr sakate hain. liposomal satahon parr cytokine koo sanyugmit karna ack upayogi drishtikon haye kyonki yeh cytokine koo unake sambandhit lakshya koshika receptors seey baandhane kii anumati detaa haye aur vaanchhit prabhaav koo prabalit karane key liye kaee davaaon koo vitarit karane kii anumati detaa haye. lipid kii satah parr cytokine koo sanyugmit karna aamtaur parr parat-darr-parat takneek kaa upayog karke kiya jaataa haye jisamen ack patali film banaane key liye parat bahulak samagri shamil hoti haye joe vaahak key bhautik gunon koo niyantrit curr sakati haye. iss nainokan design key laabhon mein anukramik maal chhodane key liye kaee dawa dibbe, lakshit aur jaiv vitaran koo prabhaavit karane key liye bahulak paraton key saath satah rasayan vigyaan koo anukoolit karane kii kshamata aur behtar pharmacokinetics shamil hain. tarksangat roop seey engineer parat-darr-parat nanoparticles ney sakriya il-12 key uchch loading aur release kaa pradarshan kiya, tumour koshikaon kii satah parr nanoparticles key sthaaniyakaran seey il-12 koo jhilli receptors key liye upalabdh honey kii anumati millie, aur pranaaleegat sampark mein kamee aaee. inn parat-darr-parat lipid nanoparticles ney il-12 vishaaktata koo kaafee cumm curr diyaa aur colorectal aur dimbagranthi tumour key khilaf antitumer gatividhi kaa pradarshan kiya joe muft il-12 delivery key saath sahan naheen kiya gayaa thaa.
soney key nainokan teji seey lokpriya hoe rahey hain kyonki way uchch satah-seey-matra anupaat pradarshit karate hain, way aasaani seey lakshit koshikaon taka yatra curr sakate hain, aur way uchch dawa bhaar kaa samarthan karate hain. inhen aasaani seey karyatmak aur sanshleshit bhee kiya jaa sakata haye. gold-bound tumour necrosis factor (tii. aine. aff.) thhos tumour key upchaar key liye charan I parikshanon mein haye. pareekshan mein paaya gayaa kii gold-bound tii. aine. aff. mein ack sahan karane yogya khuraak haye joe aparivartit tii. aine. aff. key liye sahan karane yogya khuraak seey teen gunaa adhik haye. tumour ootak mein dawa kii adhik sandrata bhee thee, joe tumour sookshm vatavaran mein sthaaniya vitaran mein vriddhi kaa sanket detee haye. soney key nainokan ack pratiraksha pratikriya praapt curr sakate hain joe unaki prabhavkarita mein baadha daalati haye, isaliye cytokine utpaadan aur pratikriyaasheel oxygen prajaati utpaadan jaise cellular pratikriya kaa mulyankan karna mahatvapurna haye.
silika nanoparticles kaa mulyankan cytokine vitaran key liye bhee kiya gayaa haye kyonki unaki uchch colloidal sthirata, vyaapak satah karyatmakta aur sanrachana aur chhidra aakar donon koo niyantrit karane kii sambhavana haye. haalaanki, badey jaiv anuon key liye cumm aantarikakaran dakshata key kaaran silika nainokan cytokine vitaran key liye seemaaen prastut karate hain. iss chunauti koo atirikt badey chhidron key saath mesoporus silika nainokanon koo vikasit karke door kiya jaa sakata haye. inn nainokanon kaa upayog soojan-rodhi aur ootak homeostasis upchaaron key liye aim2 macrophage dhruvikaran koo prerit karane key liye il-4 dene key liye kiya gayaa thaa. inn nainokanon ney il-4 ardh-jeevan mein vriddhi kii, nyuntam vishaaktata dikhaai, kushalata seey load kiya aur vitarit kiya il-4, aur aim2 macrophage dhruvikaran koo uttejit kiya
plasmid nanoparticles.
nuclic acid kaa utpaadan, shuddhikaran aur herfer karna punah sanyojak cytokins kii tulanaa mein bahut aasaan haye aur unhein sthaaniya roop seey aur tikaau roop seey vitarit karane key liye ack vidhi pradaan kartaa haye. vartamaan mein cytokine vitaran key liye vidyut sanyojan key saath cytokine koo vyakt karane vaale plasmid nanoparticles kaa pataa lagaaya jaa rhaa haye. vidyut sanyojan asthaayi roop seey jhilli sanrachana koo nuksan pahunchaae binaa koshika jhilli kii pargamyata koo badhaata haye. il-12 ack cytokine haye joe antitumer gunon key liye jaanaa jaataa haye lekin kaee rogiyon mein gambhir khuraak seey sambandhit vishaaktata dikhaata haye. ack plasmid encoding key intratumoral delivery key baad ack murine melanoma model mein electroporation key parinamswarup 47 pratishat ilaaj darr hui. charan II pareekshan ney charan III/IV unrectable melanoma key ilaaj key liye electroporation key baad plasmid encoding il-12 kii suraksha aur gatividhi kii jaanch kii. ausat uttarjeevita 3.7 maheene thee jisamen dou poorna pratikriyaon sahit 29.8% kii samagr pratikriya darr thee. koee grade IV ghatanaaen report naheen kii gaeen, aur pratikool ghatanaaen durlabh theen
cytokine vitaran koo badhaane key liye mulyankan kiye jaa rahey anya dee. aine. aeye. parisaron mein lipplex, polyplexes aur lipopolyplex shamil hain, joe kramshah lipid, polymer aur polymer key saath lipid key parisar hain. polyhtylenemine (pee. ee. aaee.) ack atyadhik cashionic bahulak haye joe nakaratmak roop seey aaveshit dee. aine. aeye. key saath jatil hotaa haye. pee. ee. dee. aine. aeye. koo vivo mein ksharan seey bachaata haye, nakaratmak roop seey aaveshit koshika jhilli key saath baatchit koo badhaava detaa haye, aur proton spunge key roop mein kaary karke lysosome seey rihaai koo badhaata haye. pee. ee. aaee.: nabulization key madhyam seey prasav key baad, aaee. ell.-12 parisaron koo fefadon key ootakon koo sankramit karane key liye dikhaaya gayaa thaa, jisase fefadon mein aaee. ell.-12 kaa utpaadan hotaa haye. saptahik yaa dou baar saptahik peeh il-12 koo athemic nagna choohon mein saus-2 maanav austiosarcoma key fuffusiya metastes koo dabaane yaa samaapt karane key liye paaya gayaa thaa. ack alag adhyayan mein, nainokanon koo ack liposomal khol aur dou dee. aine. aeye. poorak anukramon key saath banaaya gayaa thaa. liposomal khol koo phospholipase aeye2 (pee. ell. aeye. 2) dwara avakramit karane key liye design kiya gayaa thaa, joe vibhinn tumours dwara atee-abhivyakt hotaa haye. cytokine trail koo aine. aaee. 2 + sanshodhit dee. aine. aeye. core parr load kiya gayaa thaa. pee. ell. aeye. 2 key saath baatchit parr, dee. aine. aeye. nanoparticles cancer koshika jhilli parr mrityu receptors taka trail dene key liye nanofiber mein badal jaate hain. antitumer prabhavkarita koo badhaane key liye trail emplified apoptotic signalling kaa vitaran, jisamen trail key aantarikakaran mein kamee aaee haye
viral system.
oncolitic virus adhimaantah ghaatak koshikaon koo sankramit karate hain, jisase pratirakshaatmak koshika mrityu hoti haye. oncolitic virus mein adenovirus, herpes simplexes virus, semliki vann virus, poxwirus, anya shamil hain. vitaran koo anukoolit karane aur lakshit ootakon taka vitaran kii suvidha key liye unhein badala jaa sakata haye. cytokine-loaded oncolitic virus ney murine model mein gatividhi dikhaai haye, jisamen kaee naidaanik pareekshan jaanch key tahat hain. imligic (telemogen laherparewake) cancer key upchaar key liye pahala fda-anumodit oncolitic virus thaa. yeh ack sanshodhit herpes simplexes virus-1 haye joe baar-baar honey vaale melanoma key liye granulocyte-macrophage coloney-uttejak kaarak (jee. aim.-see. aiss. aff.) koo vyakt kartaa haye. vartamaan mein iska adhyayan naram ootak sarcoma aur yakrit cancer key liye aur pratirakshaatmak chikitsa key saath sanyojan key liye kiya jaa rhaa haye. cytokine delivery key liye adenovirus kaa vyaapak roop seey adhyayan kiya jaataa haye. preclinical parikshanon mein, adenovirus key intratumoral injection coding ill-12 (aid-ill-12) murine colorectal carcinoma, stun carcinoma, prostate carcinoma, glioma, mootrashay carcinoma, fibrosarcoma, swaryantra squamous cell carcinoma, hepatoma aur hepatocellular carcinoma, medulary thyroid carcinoma, thyroid follicular cancer aur eavings sarcoma key madhyasth pratigaman. aid-ill-12 kii antitumer pratiraksha pratikriya mukhya roop seey cd8 + tii koshikaon dwara madhyasthata kii jaati haye.
virus-adharit vitaran pranaliyon seey judee kaee seemaaen hain. anty-viral antibody viral cytokine delivery system key khilaf utpaadit kii jaa sakati hain jisase vilambit-prakaar kii atisamvedansheelta pratikriyaen hoe sakati hain, joe baar-baar khuraak koo roque sakati hain. rogiyon mein viral sankraman kii samvedansheelta mein bhee ack badee asamaanta haye kyonki cytokins key viral vitaran key liye mezban koshikaon key sankraman kii aavashyakta hoti haye, joe rogi seey rogi mein atyadhik parivartansheel haye. naidaanik parikshanon mein mahatvapurna off-target transgene abhivyakti bhee dekhi gaee haye. adenovirus key intratumoral injection kii chhoti matra koo yakrit, aant, pliha, gurde aur mastishk mein mahatvapurna transgene abhivyakti kaa kaaran dikhaaya gayaa thaa.
gatividhi-lakshya cytokins.
gatividhi-onn-target cytokins, jinhen actachins key roop mein jaanaa jaataa haye, utparivartit cytokins hain joe apane mool receptor complexes key liye bandhan sambandh koo cumm karate hain aur ack vishisht tumour cell receptor key liye bandhan sambandh koo badhaate hain. isase cytokine parisancharan mein nishkriya hoe jaataa haye, jisase pranaaleegat vishaaktata seemit hoe jaati haye. cytokine apane tumour-vishisht pratijan seey judane parr sakriya hoe jaataa haye, jisase sthaaniya vitaran kii anumati milati haye. cytokine tumour necrosis kaarak (tii. aine. aff.) pashu model aur rogiyon donon mein teji seey raktasraav tumour necrosis kaa kaaran banata haye lekin uchch pranaaleegat vishaaktataon seey judaa hotaa haye. tii. aine. aff. koo tumour sookshm vatavaran mein stromal koshikaon key madhyam seey apane antitumer prabhaav koo lagu karane key liye jaanaa jaataa haye. tii. aine. aff. key sthaaniya vitaran mein sudhaar karane aur endothelial koshikaon koo lakshit karane key liye isake antitumer maarg koo badalkar pranaaleegat vishaaktata koo cumm karane key liye ack tii. aine. aff. actachin banaaya gayaa thaa. iss utparivartit tnf cytokine koo kewal tumour vasculature kii endothelial koshikaon koo lakshit karane key liye dikhaaya gayaa thaa, jisase ack surakshit aur prabhaavi vitaran pranali kii anumati milati haye. iss tnf-adharit actachin key parinamswarup lakshyikaran dakshata mein 100 gunaa vriddhi hui, aur jaba actachin koo tumour vasculature kii endothelial koshikaon parr vyakt cd13 key liye lakshit kiya gayaa thaa, tou isane tumour neovasculation key chayanaatmak sakriyan kaa pradarshan kiya, binaa kissy pataa lagaane yogya vishaaktata key. jaba kaar-tii koshikaon key saath prashaasit kiya jaataa haye, tou iss chikitsa koo thhos tumour koo niyantrit karane key liye tii koshika ghuspaith koo badhaane key liye dikhaaya gayaa thaa, jabaki cd8-lakshit prakaar II interferon actachin key saath sanyojan seey thhos tumour kaa unmoolan huaa thaa.
cytokine karkhane.
cytokine karkhane koshika-janit cytokine hotey hain joe sthaaniya roop seey ruchi key cytokine koo vitarit curr sakate hain, joe khuraak key sthaanik aur asthaayi niyantran kii peshkash karate hain. messenkimal stame/stromal koshikaon (aim. aiss. see.) kii home kshamata aur tumour tropism kshamataaen unhein aadarsh dawa vitaran vaahan banaati hain. aim. aiss. see. ney laagat-uttejak anuon kii seemit abhivyakti key kaaran pratirakshaatmaktaa koo bhee cumm curr diyaa haye. cytokine koo vyakt karane key liye aim. aiss. see. kaa upayog karane seey tumour ootak koo adhik cytokine vitaran pradaan hotaa haye, jisase upchaar kii chikitsiya prabhavkarita badh jaati haye. il-2 jeane engineer aim. aiss. see. (aim. aiss. see.-aaee. ell.-2) kaa adhyayan ack sambhaavit antitumer therapy key roop mein kiya gayaa haye kyonki il-2 ack immunogenic cytokine haye. aim. aiss. see.-aaee. ell.-2 key intratumoral injection seey glioma tumour kii vriddhi mein kaafee kamee aaee aur glioma key saath choohon key samagr astitva mein sudhaar huaa. isi tarah, asthi majja msc-efn-aeye key upcharm injection ney "inn vivo" tumour key vikas koo prabhaavit kiya aur ack bahu myeloma mouse model mein samagr uttarjeevita mein vriddhi kii. tumour virodhi prabhaavon kaa shreya tumour koshikaon key apoptosis mein vriddhi, sookshm vahika ghanatva mein kamee aur ischemic necrosis koo diyaa gayaa thaa. trail ack pratirakshaatmak cytokine haye joe chayanaatmak roop seey apoptosis key liye tumour koshikaon koo lakshit kartaa haye, jisase pranaaleegat vishaaktata cumm hoti haye. atee-dabaav path key liye engineer msc ney apoptotic maargon key madhyam seey zenographt model mein ashajanak antitumer prabhaav dikhaae hain. aim. aiss. see.-trail system key kaee adhyayan jaari hain, jinamen neuroblastoma, gair-chhoti-koshika fefadon key carcinoma, stun cancer, agnashay key cancer, glioblastoma aur kaee myeloma key upchaar shamil hain.
maanav retina pigmented epithelial (aar. pee. ee.) koshikaon koo bhee cytokine kii ruchi koo vyakt karane key liye engineer kiya jaa sakata haye. aar. pee. ee. koshikaaen aadarsh cytokine vitaran pranali hain kyonki way gair-tumerogenic hain, sampark avrodh pradarshit karate hain, aanuvanshik sanshodhan key liye anukool hain, pahale upchaaraatmak vitaran pranali key liye maanav parikshanon mein upayog kiye jaane vaale beney hain, aur upayog karane key liye surakshit hain. vibhinn cytokines kaa utpaadan karane key liye engineer aar. pee. ee. koshikaon koo alginate-adharit sookshm kanon mein samaahit kiya gayaa thaa. encapsulated koshikaaen encapsulation key baad bhee vyavharya hongi, capsule key bheetar vibhajit naheen huin, ruchi key cytokine kaa utpaadan kiya, aur binaa encapsulated koshikaon kii tulanaa mein "inn vivo" mein lambe samay taka bunny raheen. il-2 dwara utpaadit rp koshikaon ney andashay aur colorectal mouse model mein peritoneal tumour koo samaapt curr diyaa, aur pharmacokinetics key computational modeling, manushyon key liye naidaanik anuvaad kii bhavishyavani karate hain, joe bhavishya key maanav naidaanik parikshanon mein sambhaavit safalata kaa sanket dete hain.