
cobatoxin

cobatoxin bichchu key vish "centroids noxius" mein maujood ack vish haye. yeh dou potasium channel upprakaron koo avaruddh kartaa haye; voltage-gated aur calcium-sakriya channel.
vyutpatti.
coba mexico kaa ack kshetra haye jahan "centroids noxius" bichchu paaya jaataa haye.
srot.
cobatoxin 1 aur 2 donon "centrorides noxius" bichchu key jahar mein paae jaate hain.
rasayan vigyaan.
sanrachana.
cobatoxin ack 32-avashesh vish (anukram aeye. vee. see. vee. aar. tii. see. dee. key. dee. key. aar. jee. aar. jee. aar. jee. jee. jee. see. aine. aich. 2) haye, jisamen 3 diasulphide pull hain, joe see1-see4, see2-see5 aur see3-see6 (see. aaee. aiss. 3-see. aaee. aiss. 22, see. aaee. aiss. 8-see. aaee. aiss. 27, aur see. aaee. aiss. 12-see. aaee. aiss. 29) parr sthit hain. peptide reedh kii huddy koo ack α/β machaan key anusaar modd diyaa jaataa haye, donon α-helical aur dou-fanse hue β-sheet sanrachanaaen maujood hain. cobatoxin 1 kaa aakar ack vistaarit aine-terminus key kaaran chhad jaisa hotaa haye.
parivaar.
cobatoxin 1 aur 2 donon α-ktx parivaar seey sambandhit hain. α-ktx parivaar k +-channel-vishisht bichchu vishaakt padarthon (ktx) kaa hissa haye, jisamen 3 parivaar hotey hain; α, β, aur γ. yeye 3 parivaar sanrachana mein bhinn hain.
lakshya.
cobatoxin 1 aur 2 donon choohon mein kv1.1 k +-chainalon koo avaruddh karate hain aur keedon mein shekar b k + chainalon koo avaruddh karate hain, joe voltage-nirbhar k +-chainalon (selisco, 1998) hain.
anya voltage-nirbhar k +-channel joe cobatoxin 1 dwara avaruddh hain, way choohon mein kv1.2 k +-channel aur choohon mein kv1.3 k +-channel hain. cobatoxin 1 bhee ikka1 caa2 +-sakriya key +-channel koo avaruddh kartaa haye.
kaarravaai kaa tarika.
cobatoxin 1 ack chhidra-avarodhak vish haye. cobatoxin 1 aur kv1.2 channel key beach kii antahkriya pahale chaar namak pulon dwara sthaapit kii jaati haye, joe cobatoxin 1 key chaar kv1.2 α-upghatakon aur amino acid avasheshon kii paarshv shrinkhalaon key beach banate hain. iss tarah seey ack sthir parisar banata haye, jise toxin-ring kahaa jaataa haye. isake baad, cobatoxin 1 aur α-subunit key beach hydrophobic antahkriya seey ack sakht antahkriya banati haye. phir cobatoxin 1 kii lies 21 side chain aayan channel key pee-domen mein pravesh karke chhidra koo avaruddh karati haye, joe kii chayanaatmaktaa filter haye.
vishaaktata.
choohon mein intracerebroventracular injection key baad cobatoxin 1 kaa 500 ± 45 ng haye.