
chayapachaya glutamate receptor 5

metabotropic glutamate receptor 5 ack uttejak gq-yugmit jee protein-yugmit receptor haye joe mukhya roop seey neurons key postsyneptic sthalon parr vyakt kiya jaataa haye. manushyon mein, yeh "jee. aar. aim. 5" jeane dwara kootbaddh kiya jaataa haye.
kaary.
emino acid ell-glutamate kendriya tantrika tantra mein pramukh uttejak neurotransmitter haye aur ionotropic aur chayapachaya glutamate receptors donon koo sakriya kartaa haye. glutamatorgic neurotransmission mastishk key samanya kaary key adhikansh pahaluon mein shamil haye aur kaee neuropathological sthitiyon mein pareshan hoe sakata haye. metabotropic glutamate receptors jee protein-yugmit receptors kaa ack parivaar haye, jinhen anukram samroopata, anumaanit sanket pargaman tantra aur aushadhiya gunon key aadhar parr 3 samoohon mein vibhajit kiya gayaa haye. samooh I mein jee. aar. aim. 1 aur jee. aar. aim. 5 shamil hain aur inn receptors koo phospholipase see koo sakriya karane key liye dikhaaya gayaa haye. samooh II mein jee. aar. aim. 2 aur jee. aar. aim. 3 shamil hain jabaki samooh III mein jee. aar. aim. 4, jee. aar. aim. 6, jee. aar. aim. 7 aur jee. aar. aim. 8 shamil hain. samooh II aur III receptors chakreeya aeye. aim. pee. cascade key avrodh seey judey hotey hain lekin unaki agonist chayanatmaktaon mein bhinn hotey hain. jee. aar. aim. 8 key vaikalpik splies roopon kaa varnan kiya gayaa haye lekin unaki poorna-lambai kii prakriti nirdhaarit naheen kii gaee haye.
lutt aur chinta jaise manovaigyaanik vikaaron mein aim. glure5 kii bhoomika parr vyaapak shodh kiya gayaa haye. ubharate shodh dridhata seey ingit karate hain kii mglur5 manushyon mein sharaab key upayog vikaar key rogjanan mein ack seedhi bhoomika nibhaata haye, joe pashu model mein ethanol key prati vyavhaar sambandhi samvedansheelta key vikas mein antarang bhagidari darshaata haye.
ligand.
orthosteric site (vaha site jahaan antarjanit ligand glutamate baandhata haye) key alawa aim. glure 5 parr cumm seey cumm dou alag-alag allosteric binding site maujood hain. shaktishali aur chayanaatmak aim. glure 5 ligand kii ack sammaanjanak sankhya, jisamen paltu jaanvaron key radiotracer bhee shamil hain, aaj taka vikasit kii gaee haye. pashu adhyayanon mein unake pradarshit chinta, avasaadarodhi aur lutt-rodhi prabhaavon aur unake apekshaakrit saumya suraksha profile key kaaran, aim. glure5 key chayanaatmak virodhi aur nakaratmak allosteric modulator aushadhiya anusandhaan key liye ruchi kaa ack vishesh kshetra hain. aim. glure 5 receptors koo kendriya tantrika tantra key baahar bhee vyakt kiya jaataa haye, aur aim. glure 5 virodhi koo hepatoprotective dikhaaya gayaa haye aur yeh soojan aur tantrika roga key dard key upchaar key liye bhee upayogi hoe sakata haye. inn davaaon kaa naidaanik upayog smritibhransh aur manodaihik lakshnon jaise dushprabhavon dwara seemit hoe sakata haye, lekin yeye kuchh sanketon key liye ack laabh hoe sakate hain, yaa isake vipareet mglur5 sakaratmak modulators kaa nutropic prabhaav hoe sakata haye.
mglur5 aur lutt.
ack nockout aim. glure5 vaale choohon mein khuraak kii parwah kiye binaa kokeen swa-prashaasan kii kamee dikhaai detee haye. isase pataa chalata haye kii receptor kokeen key laabhkaari gunon koo ekikrit karane mein ghanishth roop seey shamil hoe sakata haye. halanki, baad key ack adhyayan seey pataa chalaa kii amgler5 nockout choohon ney kokeen puraskar key liye vaisa hii jawab diyaa jaisa kii jangli prakaar key choohon ney kokeen sthaan-vareeyata pratimaan dwara pradarshit kiya thaa. ack saath liye gaye iss sakshya seey pataa chalata haye kii mglur5 dawa seey sambandhit vaadya swa-prashaasan seekhane key liye mahatvapurna hoe sakata haye, lekin sashart sanghon key liye naheen.