
sphingosine-1-phosphat receptor

sphingosine-1-phosphat receptors jee protein-yugmit receptors kaa ack varg haye joe lipid signalling anu sphingosine-1-phosphat (aiss1pee) key lakshya hain. unhein paanch upprakaron mein vibhajit kiya gayaa haih aiss1peeaaaर1, aiss1peeaaaर2, aiss1peeaaaर3, aiss1peeaaaर4 aur aiss1peeaaaर5.
khoj.
1990 mein, aiss1peeaaaर1 aiss1pee receptor parivaar kaa pahala sadasya thaa jise endothelial koshikaon seey clone kiya gayaa thaa. baad mein, aiss1peeaaaर2 aur aiss1peeaaaर3 koo kramshah choohe key mastishk aur ack maanav genomic pustakalaya seey pratiroopit kiya gayaa. anta mein, aiss1pee4 aur aiss1peeaaaर5 koo inn vitro differentiated maanav dendritic koshikaon aur rait cdna library seey clone kiya gayaa thaa.
kaary.
sphingosine-1-phosphat receptors koshika prasaar, angiogenesis, migration, cytoskeleton sangathan, endothelial cell chemotaxis, pratiraksha koshika taskari aur mitogenesis jaisi maulik javic prakriyaon koo niyantrit karate hain. sphingosine-1-phosphat receptors pratiraksha-modulan mein bhee shamil hotey hain aur seedhe tii koshikaon seey janmajaat pratiraksha pratikriyaon key daman mein shamil hotey hain.
upaprakaar.
sphingosine-1-phosphat (aiss1pee) receptors koo paanch upprakaron mein vibhajit kiya gayaa haih aiss1peeaaaर1, aiss1peeaaaर2, aiss1peeaaaर3, aiss1peeaaaर4 aur aiss1peeaaaर5.
way ootakon kii ack vistrit vividhata mein vyakt kiye jaate hain, pratyek upaprakaar ack alag koshika vishishtata kaa pradarshan kartaa haye, halanki way leukocytes parr apane uchchatam ghanatva parr paae jaate hain. aiss1peeaaaर1,2 aur 3 receptors koo sarvavyaapi roop seey vyakt kiya jaataa haye. aiss1peeaaaर4 aur aiss1peeaaaर5 kii abhivyakti cumm vyaapak haye. aiss1peeaaaर4 lymphide aur hematopoetic ootakon taka seemit haye jabaki aiss1peeaaaर5 mukhya roop seey kendriya tantrika tantra (cns) aur pliha key safed padaarth mein sthit haye.
jee protein antahkriya aur chayanaatmak ligand.
sphingosine-1-phosphat (aiss1pee) paanch upprakaron key liye antajanan agonist haye.