
koop-uttejak harmon receptor

follical-stimulating harmon receptor yaa aff. aiss. aich. receptor (aff. aiss. aich. aar.) ack transmembrane receptor haye joe follical-stimulating harmon (aff. aiss. aich.) key saath baatchit kartaa haye aur jee. protein-coupled receptor (jee. pee. see. aar.) kaa pratinidhitva kartaa haye. aff. aiss. aich. key harmonal kaary key liye iska sakriyan aavashyak haye. aff. aiss. aar. andashay, vrishan aur garbhashay mein paae jaate hain.
aff. aiss. aar. jeane.
aff. aiss. aar. key liye jeane manushyon mein gunasutra 2 pee. 21 parr paaya jaataa haye. aff. aiss. aar. key jeane anukram mein lagbhag 2,080 nucleotides hotey hain.
receptor sanrachana.
aff. aiss. aar. mein 695 emino acid hotey hain aur iska aanvik dravyamaan lagbhag 76 key. dee. aeye. hotaa haye. anya jee. pee. see. aar. kii tarah, aff. aiss. aich.-receptor mein saat jhilli-failaav kshetra yaa transmembrane helix hotey hain.
ligand binding aur signal transduction.
aff. aiss. aar. key ell. aar. aar. kshetra key liye praarambhik bandhan parr, aff. aiss. aich. ack naee jeb banaane key liye apane anuroopan koo phir seey aakar detaa haye. aff. aiss. aar. phir kaaj loop seey apane sulphotyrosine koo jeb mein daaltaa haye aur 7-helical transmembrane domen koo sakriya kartaa haye. yeh ghatana sanket key ack pargaman kii or leey jaati haye joe jee protein koo sakriya karati haye joe aantarik roop seey receptor seey bandha hotaa haye. aff. aiss. aich. sanlagn honey key saath, receptor sanrachana koo badal detaa haye aur iss prakaar, jee protein koo yaantrik roop seey sakriya kartaa haye, joe receptor seey alag hoe jaataa haye aur shivir pranali koo sakriya kartaa haye.
aisaa maanaa jaataa haye kii ack receptor anu sakriya aur nishkriya avasthaon key beach ack anuroop santulan mein maujood haye. receptor key liye aff. aiss. aich. kaa bandhan sakriya aur nishkriya receptors key beach santulan koo badal detaa haye. aff. aiss. aich. aur aff. aiss. aich.-augonist sakriya avasthaon key paksh mein santulan koo sthanantarit karate hain; aff. aiss. aich. virodhi nishkriya avasthaon key paksh mein santulan koo sthanantarit karate hain. aff. aiss. aich. key prati pratikriya karane key liye ack koshika key liye, kewal ack chhote pratishat (~ 1%) receptor saiton koo sakriya karane kii aavashyakta hoti haye.
shivir-nirbhar protein kinnesses dwara phosphorylation.
chakreeya ampy-nirbhar protein kinnes (protein kinnes aeye) jee protein (joe aff. aiss. aich.-receptor dwara sakriya kiya gayaa thaa) seey aaney vaali sanket shrinkhala dwara adenilot cyclays aur chakreeya ampy (shivir) key madhyam seey sakriya hotey hain. 
yeye protein kinnes dou niyaamak ikaaiyon aur dou utprerak ikaaiyon key saath tetramer key roop mein maujood hain. niyaamak ikaaiyon key saath shivir key bandhan parr, utprerak ikaaiyon koo chhod diyaa jaataa haye aur protein key phosphorylation kii shuruat kii jaati haye, jisase shaaririk kaarravaai hoti haye. chakreeya ampy-niyaamak diamer phosphodisteres dwara avakramit hotey hain aur 5 'ampy chhodate hain. koshika kendrak mein dna chakreeya emp pratikriya tatva (cree) key madhyam seey phosphorylated protein seey judataa haye, jisake parinamswarup jeane sakriya hotey hain.
sanket shivir kii bhagidari aur parinami phosphorylation dwara pravardhit hotaa haye. prakriya koo prostaglandin dwara sanshodhit kiya jaataa haye. anya cellular niyaamak bhaag lete hain, phospholipase, nitric acid aur anya vikas karakon dwara sanshodhit intracellular calcium sandrata.
aff. aiss. aich. receptor baahya koshikiya sanket-viniyamit sambandh (aeye. aar. key.) koo bhee sakriya curr sakata haye. ack "pratikriya tantra" mein, yeye sakriya sambandh receptor koo phosphorylate karate hain. receptor jitna adhik samay taka sakriya rahata haye, utane hii adhik kinnes sakriya hotey hain, utane hii adhik receptors phosphorylated hotey hain.
kaarravaai.
andashay mein, aff. aiss. aich. receptor follicular vikas key liye aavashyak haye aur granulosa koshikaon parr vyakt kiya jaataa haye.
purush mein, aff. aiss. aich. receptor kii pehchaan sertoli koshikaon parr kii gaee haye joe shukranujanan key liye mahatvapurna hain.
garbhashay key sravi endometrium mein luteal charan key dauran aff. aiss. aar. vyakt kiya jaataa haye.
aff. aiss. aich. receptor koo carcinogenic tumour kii ack vistrit shrinkhala kii rakt vaahikaon kii satah parr chuninda roop seey vyakt kiya jaataa haye.
receptor viniyaman.
niyaman.
operagulation jhilli parr receptor saiton kii sankhya mein vriddhi koo sandarbhit kartaa haye. astrogen aff. aiss. aich. receptor saiton koo niyantrit kartaa haye. badale mein, aff. aiss. aich. astrogen kaa utpaadan karane key liye granulosa koshikaon koo uttejit kartaa haye. astrogen aur aff. aiss. aich. kii yeh sahakriyaatmak gatividhi andashay mein koop key vikas aur vikas kii anumati detee haye.
samvedanheenta.
kuchh samay key liye aff. aiss. aich. key sampark mein aaney parr aff. aiss. aar. asamvedansheel hoe jaataa haye. iss downeragulation kii ack pramukh pratikriya protein kinnesses dwara intracellular (yaa cytoplasmic) receptor domen kaa phosphorylation haye. yeh prakriya aff. aiss. aar. seey jee. aiss. protein koo alag karati haye. shivir pranali kii niyaamak aur utprerak ikaaiyon koo alag karna asamvedansheelta koo cumm karane kaa ack aur tarika haye.
niyaman.
downeragulation receptor saiton kii sankhya mein kamee koo sandarbhit kartaa haye. yeh baadhya aff. aiss. aich. aar. saiton koo chayapachaya karke puuraa kiya jaa sakata haye. baadhya aff. aiss. aich.-receptor parisar koo paarshv pravaas dwara ack "lepit gaddhe" mein laaya jaataa haye, jahaan aisee ikaaiyaan kendrit hoti hain aur phir clathryn key dhaanche dwara sthir hoti hain. ack mudey hue lepit gaddhe koo aantarik roop seey lysosome dwara apghatit kiya jaataa haye. protein chayapachaya hoe sakate hain yaa receptor koo punarnaveenikaran kiya jaa sakata haye. lambe samay taka kaam karane vaale agonist kaa upayog receptor aabaadi koo cumm curr dega.
modulator.
aff. aiss. aar. key pratijaivik aff. aiss. aar. gatividhi mein hastakshep curr sakate hain.
aff. aiss. aich. asaamaanyataaen.
andashay key atiutsaahit syndrome vaale kuchh rogiyon mein aff. aiss. aar. key liye jeane mein utparivartan hoe sakata haye, jisase way gonadotropin uttejana key prati adhik samvedansheel hoe jaate hain.
46x gonadal disgenesis vaali mahilaaon koo hypergonadotropic hypogonadism key saath praathamik amenorrhea kaa anubhav hotaa haye. 46xx gonadal disgenesis key roop hain jinamen aff. aiss. aich.-receptor mein asaamaanyataaen bataai gaee hain aur inhen hypogonadism kaa kaaran maanaa jaataa haye.
bahuroopata aff. aiss. aich. receptor aabaadi koo prabhaavit curr sakati haye aur aaee. vee. aff. key liye aff. aiss. aich. dawa praapt karane vaali baanjh mahilaaon mein kharaab pratikriyaon kaa kaaran bunn sakati haye.
aff. aiss. aich. aar. jeane key vaikalpik vibhajan koo purushon mein baanjhapan mein fansaaya jaa sakata haye.
ligand.
follical-stimulating harmon (aff. aiss. aich.) aff. aiss. aar. kaa ack agonist haye.
aff. aiss. aar. key chhote-anu sakaratmak allosteric modulator vikasit kiye gaye hain.
itihas.
alfred jee. gillman aur martin rodbell koo jee protein pranali kii khoj key liye chikitsa aur shareer vigyaan mein 1994 kaa nobel puraskar milaa.

