corneocyte

corneocytes antim roop seey alag kiye gaye caratinocytes hain aur adhikansh star cornium, epidermis kii sabse baahari parat kii rachana karate hain. unhein niyamit roop seey nichale epidermal paraton seey apavartan aur navinikaran key madhyam seey pratisthaapit kiya jaataa haye aur twacha baadha key roop mein isake kaary key liye aavashyak hain.
sanrachana.
corneocytes binaa naabhik aur koshika-dravyamaan vaale angon key caratinocytes hain. unamen plasma jhilli key bheetar ack atyadhik aghulansheel cornified lifafa hotaa haye, aur lipid (fatty acid, sterol aur seramide) epidermis key bheetar lameller boddy seey jaari hotey hain. corneocytes ack dusare key saath paraspar judey hotey hain aur parat cornium banaane key liye 10-30 koshikaon key urdhvaadhar stambhon key roop mein vyavasthit hotey hain.
star cornium key nichale bhaag mein corneocytes koo vishesh junctions (corneodesmosome) key madhyam seey ack saath jodaa jaataa haye. way junction vighatit hoe jaate hain kyonki corneocytes twacha kii satah kii or sthanantarit hoe jaate hain aur parinamswarup vichhedan hotaa haye. usee samay, jaise hii way dheele junction adhik jalsanchayan kaa saamana karate hain, way vistaar karenge aur ack saath judenge, jisase sookshmajeevon key liye sambhaavit pravesh chhidra banenge.
star cornium paani mein apane vajan kaa teen gunaa avashoshit curr sakata haye lekin yadi isaki paani kii matra 10 pratishat seey cumm hoe jaati haye tou yeh abb naram aur daraaren naheen rahati hain.
gathan.
corneocytes apane vibhedan key antim charan mein caratinocytes hain. epidermis key star besel mein caratinocytes koshika vibhajan key madhyam seey gunaa karenge aur twacha kii satah kii or pravaas karenge. usa pravaas key dauran caratinocytes star cornium taka pahunchane key baad antatah corneocytes banane key liye vibhedan key kaee charanon seey gujarenge. corneocytes koo lagaatar disquamation yaa ragadane, twacha dhone yaa detergent key madhyam seey samaapt kiya jaataa haye, way lagaatar caratinocyte vibhedan key madhyam seey bhee banate hain.
corneocytes, jinhen squame key roop mein bhee jaanaa jaataa haye (lattin "squama" seey, jiska arth haye "patali parat" yaa "taraju") antim roop seey bhinn hotey hain, caratinocyte vansh kii naabhikiya koshikaaen joe parat cornium key bahumat kaa gathan karati hain, joe epidermis kii sabse baahari parat haye. corneocyte kaa aakar lagbhag 30-50 microne vyaas aur 1 microne motaa hotaa haye, aur twacha kii satah parr corneocyte kaa ausat kshetra lagbhag 1000 microne taka pahunch jaataa haye, lekin shaaririk sthaan, ayu aur baahari paryavaraniya sthitiyon jaise kii parabaingani (yuvi) vikiran key anusaar bhinn hoe sakata haye. corneocytes key pramukh ghatak twacha kii samagr sanrachana koo kathorta dene key liye ack matricks banaane key liye samanantar bandalon mein vyavasthit keratin madhyavarti tantu hain.
kaary.
corneocytes kii paraten uchch yaantrik shakti kaa utpaadan karati hain joe twacha key epidermis koo ack bhautik, rasayanik aur pratirakshaatmak baadha key roop mein apana kaary karane kii anumati detee hain. udaaharan key liye, corneocytes shareer key ander koshikaon koo apoptosis aur dee. aine. aeye. kshati seey bachaate hue, bikhare hue yuu. vee. vikiran koo pratibimbit karke yuu. vee. baadha key roop mein kaary karate hain. choonki corneocytes anivarya roop seey mrit koshikaaen hain, way viral hamalon key liye pravan naheen hain, halanki adrishya sookshm gharshan pargamyata kaa kaaran bunn sakate hain. twacha mein rogjanakon key upanivesheekaran koo harr 2-4 saptah mein corneocyte parat key poorna turnover key madhyam seey rokaa jaataa haye. corneocytes twacha koo hydrated rakhane aur isake lachilepan koo banaae rakhane key liye thodi matra mein paani koo avashoshit karane aur sangraheet karane mein bhee saksham hain.
praakritik moisturising kaarak.
corneocytes mein praakritik moisturising kaarak naamak chhote anu hotey hain, joe corneocytes mein thodi matra mein paani koo avashoshit karate hain jisase twacha koo hydrate kiya jaataa haye. praakritik moisturising kaarak philagrin naamak hystidine-samriddh protein key ksharan seey utpaadit paani mein ghulansheel yaugikon kaa ack sangrah haye, joe keratin tantuon koo ekatrit karane key liye jimmedaar hain taaki keratin bundles bunn sakein joe stratum cornium mein koshikaon kii kathor sanrachana koo banaae rakhate hain. jaba philagrin kaa ksharan hotaa haye, tou euria, pyrolidone carboxylic acid (1,2), glutamic acid aur anya amino acid kaa utpaadan hotaa haye. inhen saamoohik roop seey twacha key "praakritik moisturising kaarak" key roop mein sandarbhit kiya jaataa haye. praakritik moisturising kaarak key ghatak vayumandal seey paani koo avashoshit karate hain taaki yeh sunishchit kiya jaa sakey kii parat cornium kii satahi paraten hydrated rahein. choonki way swayam paani mein ghulansheel hotey hain, isaliye atyadhik paani kaa sampark unhein nikhaar sakata haye aur unake samanya karyon koo roque sakata haye, yahee kaaran haye kii paani key saath lambe samay taka sampark twacha koo shushk banaata haye. antahkoshikiya lipid parat pratyek corneocyte key baahar koo seal karke praakritik moisturising kaarak key nuksan koo rokane mein madad karati haye.
baahya koshikiya sanrachanaaen.
halanki stratum cornium jyaadaatar corneocytes seey banaa hotaa haye, anya sahayak sanrachanaaen stratum cornium key kaary mein sahaayata key liye extracellular matricks mein maujood hoti hain. inmein shamil hainh
lameller boddy.
lameller boddy tubeler yaa andashay key aakar key sravi anga hotey hain joe stratum spinosum key oopari bhaag mein caratinocytes key golgi upkaran seey praapt hotey hain. utpaadan sthal seey, lameller nikaay star granulosum key sheersh parr aur phir star cornium key antarkoshikiya kshetra mein apani samagri koo baahar nikaalane key liye pravaas karate hain, joe mukhya roop seey lipid hotey hain. lipid antatah lameller lipid bilayer banaate hain joe corneocytes koo gherta haye aur stratum cornium key pargamyata baadha homeostasis mein bhee yogdan detaa haye. homeostasis kaary epidermis mein calcium pravanata dwara niyantrit kiya jaataa haye. aamtaur parr stratum cornium mein calcium kaa star bahut cumm hotaa haye, lekin stratum granulosum mein uchch hotaa haye. ack baar pargamyata baadha baadhit honey key baad parat cornium mein paani kaa pravaah hotaa haye, joe badale mein parat cornium mein calcium key star koo badhaata haye lekin parat granulosum mein ise cumm curr detaa haye. yeh gadbadi lameller nikaayon koo exocytosis seey gujarane key liye prerit karati haye aur staree cornium key pargamyata baadha kaary koo punah praapt karane key liye glycosylceramide, collestroll aur phospholipids jaise lipid kaa sraav karati haye.
antahkoshikiya lipid (lameller lipid dwi-parat).
corneocytes vishesh lipid key ack matricks mein antarnihit hotey hain joe stratum cornium volume kaa lagbhag 20 pratishat hotey hain. staree cornium mein antahkoshikiya lipid key pramukh ghatakon mein seramide (dravyamaan dwara 30-50%), collestroll (dravyamaan dwara 25 pratishat) aur mukt vasaa acid (dravyamaan dwara 10-20%) shamil hain, joe jyaadaatar lameller nikaayon dwara utpaadit hotey hain. yeye hydrophobic ghatak ack saath mill curr corneocytes key beach lipid key kaee dwi-star banaate hain taaki paani aur electrolytes key pargamyata andolan mein pramukh baadha key roop mein kaary kiya jaa sakey.
cornified lifafa.
cornified lifafa ack protein kavach haye joe pratyek corneocyte koo gherta haye. isaki motai 15 aur 20 nm key beach hoti haye. atyadhik aghulansheel cornified lifafa loricrin, involucrine, envoplakin aur periplakin jaise ghulansheel poorvavarti proteins koo cross-linking seey banata haye.
corneodesmosome aur disquemation.
star cornium kii samagr akhandata koo corneodesmosome naamak vishesh antarkoshikiya protein dwara banaae rakhaa jaataa haye. teen chipakane vaale protein desmoglin-1, desmocolin-1 aur corneodesmosine corneodesmosome kii rachana karate hain aur nikatvarti corneocytes koo jodane key liye samanjasya bull pradaan karate hain. corneodesmosome key ghatak dheere-dheere protein koo pachaane vaale enzymon dwara kharaab hoe jaate hain, kyonki corneocytes koo twacha kii satah kii or dhakel diyaa jaataa haye. baahari twacha kii satah mein kamjor corneodsamosome key parinamswarup, corneocytes kii sabse oopari paraten gharshan balon jaise ragadane yaa dhone key madhyam seey bahishkrit hoe jaati hain. yeh prakriya twacha key rogjanakon koo twacha key upanivesh seey rokane key liye twacha kaa ack samanya surakshaatmak tantra haye, aur ise disquamation key roop mein sandarbhit kiya jaataa haye. swasth twacha mein, disquemation ack adrishya prakriya haye aur ootak kii motai banaae rakhate hue 2-4 saptah key bheetar parat cornium poori tarah seey badal jaataa haye.
shushk twacha (zerosis).
shushk twacha (zerosis) mein parat cornium (hypercaratosis) kii motai mein vriddhi hoti haye, joe umr badhane, paryaavaran kii aardrata yaa yuvi vikiran sahit vibhinn karanon seey hoe sakati haye. twacha kii satah parr corneocyte key guchhe jamaa honey seey squam key asamanya algaav koo dikhaai dene vaale samoohon key roop mein utpann curr sakate hain. zerosis aam haye, vishesh roop seey bujurg vyaktiyon mein joe mukt amino acid kii matra mein kamee key kaaran hoe sakata haye, joe praakritik moisturising kaarak kaa ack ghatak haye. natijatan, baajaron mein kaee moisturiser praakritik moisturising kaarak key saath-saath keratin aur elastine key ghatakon koo shamil karate hain.
sthaaniyakaran.
corneocytes epidermis key stratum cornium kaa hissa hain aur twacha key baadha kaary mein yogdan karate hain.

