
intranasal dawa vitaran

intranasal dawa vitaran taba hotaa haye jaba kanon koo naak guha mein saans seey ander liya jaataa haye aur seedhe tantrika tantra mein leey jaaya jaataa haye. halanki davaaen naak mein inject kii jaa sakati hain, kuchh chintaon mein chot, sankraman aur surakshit niptan shamil hain. adhyayanon seey pataa chalata haye kii rogi key saans lene mein sudhaar huaa haye. mastishk kii beemariyon kaa ilaaj karna rakt mastishk baadha key kaaran ack chunauti rahee haye. pichhale adhyayanon ney mastishk rogon aur mansik swaasthya sthitiyon key liye intranasal maarg key madhyam seey prasav upchaar kii prabhavkarita kaa mulyankan kiya. intranasal prashaasan ack sambhaavit maarg haye joe naak seey mastishk mein uchch dawa hastaantaran aur dawa jaiv upalabdhata seey judaa huaa haye.
dawa vitaran kaa itihas.
dawa vitaran maanav rogon key ilaaj key liye upchaar dene kii ack prakriya haye. pahali dawa vitaran pranali aksar 1950 key dashak kii haye, jahan smith cline aur french prayogshalaon ney spanule takneek kii shuruat kii thee. 1950 aur 1980 key dashak key beach, maukhik aur transdermal anuprayogon key liye chaar dawa release system vikasit kiye gaye theh vighatan, prasaar, parasaran, aur aayan-vinimay niyantrit release. baad mein 1980 key dashak mein, lupron dipo praudyogiki ney shoonya-crum aur deerghakaalik release system kii peshkash karke kshetra koo aur unnat kiya. pichhale kuchh dashakon mein, iss kshetra mein behtar dawa formulation, release tantra, vitaran samagri aur prashaasan maargon key saath lubhavani pragati dekhi gaee haye. hriday aur shwasan rogon key ilaaj key saath 20veen shatabdi key anta mein intranasal maarg ney ruchi praapt kii. 1980 key dashak key anta mein, villium free II ney mastishk rogon key ilaaj key liye intranasal maarg kaa adhyayan kiya. taba seey, yeh naak seey mastishk taka pahunchane kaa ack sambhaavit maarg bunn gayaa haye.
shareer rachana vigyaan.
intranasal delivery maarg.
naak guha atyadhik samvahani hoti haye joe anuon koo seedhe tantrika tantra mein kushal hastaantaran mein saksham banaati haye. mastishk koo lakshit karane key liye prashaasan key anya maargon kaa upayog karate samay, pranaaleegat parisancharan prabhaav aur rakt mastishk baadha key muddon key kaaran dawa kaa avashoshan cumm hotaa haye. naak guha key madhyam seey dawa kii delivery dawa kii jaiv upalabdhata koo badhaati haye aur pranaaleegat sampark key jokhim koo cumm karati haye. nasika guha enzymon key saath thodaa amleeya vatavaran haye joe dawa vitaran pranaliyon key ksharan koo badal sakata haye. intranasal prashaasan key baad uchch dawa jaiv upalabdhata key liye tatasth seey amleeya ph key beach vitaran pranali aadarsh haye. guha kaa shwasan kshetra badey satah kshetra key saath sabse adhik samvahani haye. yeye guna ise dawa hastaantaran aur pranaaleegat parisancharan key liye avashoshan key liye praathamik sthal banaate hain. ghraan kshetra koo lakshit karane seey naak seey mastishk taka dawa vitaran kii dakshata badh jaati haye. ghraan kshetra mein shleshma jhilli hoti haye jisamen ghraan bulb seey judee ghraan tantrika hoti haye. jaba kann tantrika tantuon key madhyam seey ghraan bulb mein preshit hotey hain, tou unaki mastishk taka seedhi pahunch hoti haye. intranasal kanon koo shleshma parat, pahali baadha seey gujarna padata haye, phir naak key upkala seey mastishk taka yatra karni hoti haye. shleshma jhilli nakaratmak roop seey aaveshit hoti haye aur isamen hydrophobic kshetra hotey hain. yeye guna dawa prasaar koo prabhaavit karate hain. kull milakar, yeh prasav maarg mastishk rogon aur mansik swaasthya sthitiyon key ilaaj key liye ack sambhaavit maarg haye. 
mastishk kaa rakt avrodh.
rakt mastishk baadha (bee. bee. bee.) mastishk key samvahani network kii ardhpargamya jhilli haye. vishesh roop seey, yeh mastishk key rakt aur antaraaliya drav key beach ack baadha haye. yeh keshikaon mein endothelial koshikaon, khagoliya koshikaon aur pericites key beach tanga junctions seey banata haye. bee. bee. bee. mein uchch vidyut pratirodh haye. kuchh beemaariyaan iss baadha koo nuksan pahuncha sakati hain aur risaav kaa kaaran bunn sakati hain. imandari banaae rakhna mahatvapurna haye. shodhon seey pataa chalata haye kii vitamin aur antioxidant kaa sevan badhaane key saath-saath tanaav mein kamee seey mastishk kii rakt baadha koo bahaal kiya jaa sakata haye. yeh shareer mein sabse adhik chayanaatmak baadha haye joe vilayan, badey aur hydrophilic anuon aur pratiraksha karakon key nishkriya prasaar koo pratibandhit karati haye. dou anu guna joe bee. bee. bee. key madhyam seey andolan koo prabhaavit karate hain, way hain satah kii gatividhi aur aakar. iss sanrachana kaa mukhya uddeshya mastishk koo rogjanakon yaa vishaakt padarthon seey bachaana haye. pratibandhaatmak baadha homeostasis koo banaae rakhti haye aur neuronal karyon mein kissy bhee parivartan koo rokti haye. isaliye, davaaen seedhe mastishk taka pahunchaana chunautipurna haye.
naak seey mastishk taka dawa vitaran parr haal key adhyayan.
alzheimer.
tantrika-apakshayi roga tantrika-tantrikiya sanrachana aur kaary key nuksan seey hotey hain. neurons kaa yeh pragatisheel apakshay aparivartaniya haye. alzheimer ack neurodegenerative bimari haye joe alpakaalik smriti haani key saath shuru hoti haye joe hriday gati aur saans parr niyantran key nuksan key liye aage badhati haye. 1906 mein pahali baar vishva roga koo duniya key saamane pesh kiye jaane key 100 seey adhik saal hoe chuke hain. alzheimer key ilaaj key liye intranasal delivery kii prabhavkarita key liye pramaan hain. insulin key intranasal delivery ney swasth vyaktiyon kii tulanaa mein alzheimer key rogiyon mein adhik smriti sudhaar dikhaaya. microglial sakriyan soojan mein vriddhi alzheimer kii visheshataaen hain. pashu adhyayanon seey pataa chalata haye kii pro-resolving lipid madhyasthon key intranasal prashaasan ney donon karakon koo cumm curr diyaa, jisase iss bimari key rogjanan koo dheema curr diyaa gayaa. intranasal maarg key madhyam seey ack nae peptide koo vitarit karane seey amyloid beeta plake cumm hoe jaate hain, joe alzheimer kii ack paribhaashit visheshta haye aur sangyanatmak karyon mein vriddhi hoti haye. khargoshon mein hydrogel key madhyam seey chhitare gaye anty-alzheimer dawa kii intranasal delivery ney maukhik goliyon kii tulanaa mein uchch jaiv upalabdhata kaa pradarshan kiya. meer132 ack aar. aine. aeye. anu haye joe neuronal morphology koo niyantrit kartaa haye aur astitva banaae rakhta haye. yeh anu alzheimer key saath viniyamit haye. ack adhyayan ney iss darpan seey bharey pegg-plaa nanoparticles koo naak key maarg seey choohon koo prashaasit kiya. iss naveen chikitsa ney meer132 kii abhivyakti mein vriddhi aur smriti kaary mein sudhaar dikhaaya. intranasal delivery kii prabhavsheelta koo majboot karane key liye, rakt mastishk baadha key paar dawa parivahan mein behtar sudhaar key liye pargaman badhaane vaale vikasit karane key liye adhyayan hain.
glioblastoma.
mastishk key ootak yaa aspas key kshetron mein asamanya koshika vriddhi aur dravyamaan kaa gathan mastishk cancer kaa kaaran bunn sakata haye. lagaatar sirdard, daure aur dhundhali drishti samanya lakshan hain. glioblastoma (jee. bee. aim.) sabse teji seey badhane vaalaa aur sabse ghaatak mastishk tumour haye. haalaanki glioblastoma kaa mukhya kaaran agyaat haye, yeh taba utpann hotaa haye jaba astrocytes utparivartit hotey hain aur mastishk key saamane aur asthaayi khandon mein aniyantrit roop seey tumour banaate hain. vartamaan upchaar key saath chunauti swasth mastishk ootak key liye koee vishaakt prabhaav key saath tumour cell apoptosis shuru karna haye. intranasal maarg key madhyam seey vitarit chemotherapeutics seey bharey nainokan glioblastoma key ilaaj mein ashajanak parinam dikhaate hain. pee. ell. jee. aeye.-adharit nainokanon mein paclitexel yaa doxorubicin seey bharaa huaa ack aar. jee. dee. anukram key saath sanyugmit hotaa haye joe glioblastoma sookshm vatavaran koo lakshit kartaa haye aur koshika mrityu key madhyam seey tumour kii matra koo cumm kartaa haye. microrna-21 (meer-21) glioblastoma kii pragati koo badhaane vaale pro-apoptotic jeane koo rokta haye. anty-tumour peptides key saath utpaadit swa-sanyojan vaale nanoparticles koo intranasli prashaasit kiya gayaa aur tumour cell apoptosis koo badhaane vaale meer-21 key star koo cumm kiya gayaa.
mirgi.
sankraman, sir kii chot, yaa stroke achaanak neuronal gatividhi key fatane kaa kaaran bunn sakate hain jisase asamanya vyavhaar, maanspeshiyon kii gati aur manodasha mein parivartan hoe sakata haye. iss sthiti koo jabti key roop mein jaanaa jaataa haye. mirgi kii visheshta baar-baar aaney vaale daure hain. mirgi key kuchh sambhaavit karanon mein asantulan yaa neurotransmitter, stroke yaa mastishk kii chot kaa vyavadhaan shamil haye. carbamazepine nanoparticles kii intranasal delivery antipileptic dawa jaiv upalabdhata koo badhaati haye. parkinsons roga key ilaaj key liye neuroactive davaaon key saath ack swa-sanyojan hydrogel kaa prashaasan jaiv-sangat, vishaaktata mein cumm, aur achchi punarpraapti kshamata vaalaa prateet hotaa haye. iss jail key naak seey vitaran ney mastishk mein dawa kii ekagrata mein vriddhi kaa pradarshan kiya. oxytosin ack harmon haye joe autism vaale logon mein chinta key lakshnon koo cumm karane key liye dekhaa jaataa haye. intranasal prashaasan ney naak guha seey mastishk mein aushadhiya roop seey sakriya oxytosin key kushal hastaantaran kaa sanket diyaa.
parkinsons.
alzheimer key samaan, parkinsons santulan aur samanvaya key muddon, maanspeshiyon kii kathorta aur compcompy seey judee sabse aam neurodegenerative bimari haye. 1800 key dashak kii shuruat mein, james parkinson ney iss bimari koo chikitsakiya roop seey paribhaashit kiya. sanyugmit mitochondrial pranaliyon key intranasal vitaran key baad ack adhyayan ney parkinsons key saath choohon mein gatiman kshamataon mein sudhaar dekhaa. ack anya adhyayan ney hydrogel mein neuroactive davaaon key vitaran kaa pradarshan kiya, jisase naak guha mein nivaas samay aur mastishk mein ekagrata mein vriddhi hui. nanocarriers key saath sanyukt upchaar koo lakshit koshikaon mein seedhe davaaon koo sthanantarit karane aur sanchay koo badhaane key liye dikhaaya gayaa haye. dekhe gaye prabhaavon mein behtar neuronal signalling aur locomotion shamil hain. isake alawa, lactopherine key saath sanshodhit jaiv-apghataniya nainokanon kii satah kaa intranasal vitaran mastishk mein sanchay aur koshikiya grahan mein vriddhi kartaa haye.
avasaad.
neuroplasticity key nuksan kii visheshta, avasaad ack samanya manodasha vikaar haye joe lagaatar nakaratmak bhaavanaon aur jeevan shally mein parivartan kaa kaaran banata haye. relaxin-3 mimatics key intranasal delivery ney choohe key model key vyavhaar pratimanon mein mahatvapurna avasaad-rodhi gatividhi kaa pradarshan kiya. berberin seey bharaa ack thermoresponsive hydrogel pradaan karna, joe hippocampus aur avasaadarodhi gatividhi mein uchch jaiv upalabdhata kaa pradarshan kartaa haye.
chinta.
chinta hippocampus key kaary koo baadhit curr sakati haye jisase avasaad aur manobhransh kaa khatra badh jaataa haye. ack bharey hue polymeric nanoparticles key intranasal delivery key baad pashu model mein chinta key prabhaav dekhe gaye. ack anya adhyayan ney sanket diyaa kii neuropeptide key intranasal delivery seey choohon mein chinta cumm hoe gaee.
anorexia nervosa.
anorexia nervosa (aine) ack samanya khaane kaa vikaar haye jisaki visheshta vajan badhane key darr seey bhojan kaa cumm sevan haye. iss puraane vikaar seey kaee jatilataaen judee hui hain jaise kii thakan, anidra aur nimn raktchaap. bhojan kii pratyasha aur khaane kii chinta mein kaafee kamee vaale rogiyon mein oxytosin kaa intranasal prashaasan.
maadak dravyon key upayog kaa vikaar.
kissy padaarth, maadak padarthon yaa sharaab kaa aniyantrit aur nirantar upayog, maadak padaarth upayog vikaar key roop mein jaanaa jaataa haye. padaarth neuronal signalling mein hastakshep curr sakate hain aur sambhaavit roop seey mastishk paripath koo baadhit curr sakate hain. inn padarthon kii lutt soch, vyavhaar aur anya javic karyon koo baadhit karati haye. insulin kii intranasal delivery mastishk chayapachaya gatividhiyon mein sudhaar aur aaveg koo cumm karane seey judee haye. opioid kii lutt prachalit haye aur kaee maadak padarthon key sevan seey honey vaali mauton seey judee hui haye. ack adhyayan mein mastishk mein uchch jaiv vitaran aur naloxone-loaded lipid nanoparticles key saath prashaasit choohon mein opioid overdose mein kamee dekhi gaee.
post-traumatic strace disorder.
ack vinashkari yaa bhayaanak sthiti kaa saamana karna post-traumatic strace disorder (ptsd) kaa kaaran bunn sakata haye. yeh mansik swaasthya sthiti chinta, avasaad aur yaadon key saath atyadhik bhaya koo trigger karati haye. pee. tii. aiss. dee. davaaon seey bharey tapman-samvedansheel hydrogel key intranasal prashaasan ney mastishk key lakshit prabhaav aur ootak vitaran koo badhaaya. isi tarah, ack anya adhyayan mein loaded hydrogel key intranasal prashaasan key saath anty-pee. tii. aiss. dee. prabhaav dekhe gaye.
schizophrenia.
schizophrenia mastishk rasayan vigyaan aur sanrachana mein parivartan key kaaran honey vaali ack purani mansik swaasthya sthiti haye. aanuvanshiki aur paryaavaran iss vikaar key vikas mein ack mahatvapurna bhoomika nibhaate hain. shodh seey pataa chalata haye kii bigadi hui jeane abhivyakti yaa rasayanik asantulan iss sthiti koo prabhaavit curr sakata haye. chinta seey schizophrenia kaa khatra badh sakata haye aur lakshnon mein matibhram, avyavasthit bhaashan aur asamanya vyavhaar shamil hain. devunatide (aine. aeye. pee.) gatividhi-nirbhar neuroprotective protein (aeye. dee. aine. pee.) kaa ack khand haye. adnp koo schizophrenia key saath viniyamit honey kii soochana haye. ack adhyayan mein dekhaa gayaa kii jaba intranasal maarg key madhyam seey jhapaki key saath ilaaj kiya jaataa haye tou choohon mein atee sakriyata mein kamee aatee haye.
migraine.
migraine teevra sirdard key episode key saath hotaa haye jisase matali aur galaa dard hotaa haye. tanaav aur harmonal parivartan migraine kaa kaaran bunn sakate hain. sumatriptan yukt ack naak spray ney migraine dard mein mahatvapurna kamee kaa pradarshan kiya. sumatriptan (aiss. tii.) key intranasal prashaasan key aage key naidaanik adhyayan iss tarah kii vitaran pranaliyon kii prabhavkarita aur suraksha kaa mulyankan karane mein madad curr sakate hain.
intranasal dawa vitaran key liye nanosystem.
nainokaniyaan dawa vitaran pranali hain jinka vyaas 1-1000 nm seey hotaa haye. lipid-adharit aur bahulak-adharit nanocarrier aamtaur parr naak seey mastishk taka pahunchaane key liye upayog kiye jaate hain kyonki way uchch sthirata, ghulansheelata aur paalan karate hain. exosome aur dendrimer anya sambhaavit nanocarrier hain. nanosystem koo bhautik yaa rasayanik tarikon kaa upayog karke sanshleshit kiya jaa sakata haye. kuchh bhautik vidhiyon mein vashpikaran-sanghanan pratikriya aur lazer kshay shamil hain. vikiran, sookshm emulsion aur rasayanik kamee nanoparticles vikasit karane key liye samanya rasayanik takneeken hain. sonication, electroporation aur incubation, davaaon koo nanocarrier mein load karane key liye samanya tareeke hain. 
inn nanosystem koo mucodesive agents, uttejana-samvedansheel samagri yaa antibody key saath lepit karane seey jaiv-sangatata, nikasi darr, vishishtata aur jaiv upalabdhata mein vriddhi hoe sakati haye. pravesh aur avashoshan badhaane vaale pranali kii samagr prabhavkarita koo kaafee badhaa sakate hain. dawa hastaantaran dakshata aur jaiv upalabdhata key maapan key saath imaging adhyayan inn dawa vitaran pranaliyon kii bhoomika kaa samarthan curr sakate hain. 
lipid-adharit nainokan.
lipid-adharit nainokan (lnp) cumm vishaaktata aur niyantrit rihaai key saath anuon koo vitarit curr sakate hain. liposome, thhos lipid nanoparticles (aiss. ell. aine.), nanostructured lipid vaahak (aine. ell. see.) aur nanoemulsion udaaharan hain. 
liposome phospholipids seey baney hotey hain joe golakar putika banaate hain. yeh guna liposome koo uchch jaiv sangatata aur jaiv apghatansheelta pradarshit karane mein saksham banaata haye. adhyayanon mein anunaasik guha mein pratidhaaran aur avashoshan mein vriddhi aur uchch mastishk jaiv vitaran key kaaran mastishk kii beemariyon key ilaaj key liye liposome key sambhaavit anuprayog kii report kii gaee haye. ack pichhale adhyayan ney aim. aar. aine. aeye. aur green fluorescent protein (jee. aff. pee.) seey bharaa ack cashionic liposome vikasit kiya. murine model mein iss sutrikaran key intranasal vitaran ney uchch mastishk jaiv vitaran aur aim. aar. aine. aeye.-jee. aff. pee. kii abhivyakti kaa pradarshan kiya.
thhos lipid nanoparticles (aiss. ell. aine.) thhos lipid seey baney hotey hain joe ack matricks banaate hain aur surfactants dwara sthir hotey hain. way uchch bhautik sthirata pradarshit karate hain aur vibhinn taapmaanon parr thhos sthiti mein rahate hain. ack adhyayan key aadhar parr, revastigmine tartrait (aar. tii.) seey bharey slan kii intranasal delivery ney koee vishaaktata, sthirata aur behtar jaiv upalabdhata kaa pradarshan naheen kiya. kabhi-kabhi kathorta aur aakar mein cumm lachilepan key kaaran fatane kii rihaai hoe sakati haye. 
nanostructured lipid vaahak (aine. ell. see.) thhos aur jaleey lipid key mishran dwara sanshleshit hotey hain. aine. ell. see. aiss. ell. aine. aiss. seey vikasit kiye jaate hain, iss prakaar inhen doosari peedhi key ell. aine. pee. aiss. key roop mein sandarbhit kiya jaataa haye. curcumin (see. aar. aim.) seey bharey aine. ell. see. key intranasal prashaasan ney mastishk cancer key liye ack sambhaavit pranali key roop mein ubharane key baad mastishk mein jaiv vitaran aur ekagrata mein vriddhi kii.
tail, jaleey charanon aur payasikari yukt mycel seey bunny chhoti colloidal pranaliyon koo nanoemalsion kahaa jaataa haye. glioblastoma key ilaaj key liye temozolomide seey bharey jail nanoemalsion kii intranasal delivery nirantar rihaai aur naak seey mastishk taka behtar pargaman pradarshit karane key liye dekhi jaati haye.
bahulak-adharit nainokan.
bahulak-adharit nainokanon koo praakritik yaa kritrim sroton seey banaaya jaa sakata haye. nanosphere aur naino capsule polymeric nanopartical system hain. praakritik polymer paryaavaran yaa maanav shareer mein paae jaa sakate hain. doosari or, synthetic polymer praakritik roop seey naheen hotey hain aur rasayanik sanshodhanon key saath kritrim roop seey vikasit polymer hotey hain. praakritik bahulak-adharit nainokan chitosan, hyluronic acid, alginate aur gelatin seey baney hoe sakate hain. praakritik polymer utkrisht jaiv sangatata aur jaiv apghatansheelta aur cumm vishaaktata pradarshit karate hain. synthetic polymer-adharit nanoparticles mein polly (glycolic acid) (pee. jee. aeye.), polly (lactic acid) (pee. ell. aeye.) aur polly (ell-lactide-koo-glycolide) (pee. ell. jee. aeye.) hoe sakate hain. 
ack adhyayan ney mirgi key ilaaj key liye mirgi rodhi dawa, phenitoin (pht) seey bharey chitosan nanoparticles kaa mulyankan kiya. avalokan ney uchch sthirata, nirantar rihaai aur jaiv upalabdhata kaa sujhaav diyaa jaba yeye kann intranasal maarg key madhyam seey prashaasit hotey hain. isi tarah, bahulak-adharit nainokanon, pluga nainokanon seey bharey lamotrigin (ell. tii. jee.), koo prashaasit karane seey bee. bee. bee. key madhyam seey behtar pargaman aur uchch jaiv upalabdhata dikhaai dee.
exosome.
exosome aanuvanshik jaankaari vaali putika sanrachanaaen hain. haal hii mein, exosome kaa upayog dawa vaahak key roop mein kiya jaa rhaa haye. inn pranaliyon koo sthir, vishisht aur surakshit maanaa jaataa haye. isake alawa, exosome kii delivery cumm pratirakshaatmak prabhaav dikhaati haye. aage satah sanshodhan aur liposome key saath sanyugman chikitsiya prabhaavon koo badhaata haye. pichhale adhyayan key aadhar parr, ack state 3 avarodhak seey bharey exosome key intranasal delivery ney mastishk kii soojan koo cumm curr diyaa aur mastishk tumour key vikas koo dheema curr diyaa.
dendreamers.
dendrimer ack pedh kii sanrachana key samaan ack shakha network key saath polymeric macromolecule hain. aam taur parr, way golakar aur sajaatiya hotey hain. satah charge aur anu rasayan vigyaan dawa kii paraspar kriya aur rihaai key saath mahatvapurna bhoomika nibha sakate hain. polly (amidoemine) (pyaamam) dendrimer sabse adhik upayog kii jaane vaali pranali haye. ack adhyayan ney dendrimer-adharit heloperidol key sambhaavit anuprayog kii jaanch kii. intranasal prashaasan ney mastishk mein behtar lakshyikaran, aur ghulansheelata key saath-saath uchch sandrata dikhaai. davaaon koo sutrikaran aur naino-nirmaan key madhyam seey dendrimer mein load kiya jaa sakata haye.
bhautik rasayanik gunon kaa mahatva.
rakt mastishk baadha koo darkinar karane key liye dawa vitaran pranaliyon key liye, bhautik rasayanik gunon key sanshodhan suraksha aur prabhavkarita koo badhaa sakate hain. aakar, satah charge aur lipophilicity rakt mastishk baadha koo darkinar karane vaale padaarth mein ack pramukh bhoomika nibhaate hain. chhote, sakaratmak roop seey aaveshit, yaa adhik lipophilic anu naak seey mastishk taka vitaran kii prabhavkarita koo badhaate hain. vitaran pranali key aakar mein kamee pargaman koo badhaati haye. choonki jhilli nakaratmak roop seey aaveshit hoti haye, isaliye sakaratmak satah avesh vaalaa ack kann sthir vidyut kriya kartaa haye joe jaiv asanjan koo badhaata haye. adhik lipophilicity vaale vaahak behtar mucodation aur nivaas samay kaa prayog karate hain. dawa pranali ph, ghulansheelata aur hydrogen bandhan kshamata anya bhautik rasayanik guna hain jinka mulyankan kiya jaanaa chaahiye. 

