seenel austeoporosis

seeneel austeoporosis koo haal hii mein ack vishesh pathophysiology key saath ack jarachikitsa syndrome key roop mein pahachaana gayaa haye. austeoporosis key vibhinn vargeekaran hainh praathamik, jisamen huddy kaa nuksan umr badhane kaa parinam haye aur maadhyamik, jisamen huddy kaa nuksan vibhinn naidaanik aur jeevan shally karakon seey hotaa haye. praathamik, yaa anaichhik austeoporosis, koo aage prakaar I yaa prakaar II mein vargeekrit kiya jaa sakata haye. type I rajonivritti key baad key austeoporosis koo sandarbhit kartaa haye aur astrogen kii kamee key kaaran hotaa haye. jabaki seenel austeoporosis koo ack anaichhik, prakaar II aur praathamik austeoporosis key roop mein vargeekrit kiya gayaa haye, joe 70 varsh kii ayu seey adhik purushon aur mahilaaon donon koo prabhaavit kartaa haye. isake saath vitamin dee kii kamee, shareer mein calcium koo avashoshit karane mein viphalata aur parathyroid harmon mein vriddhi hoti haye.
varshon seey kiye gaye shodh seey pataa chalaa haye kii seenel austeoporosis jeevan key ack unnat charan mein ack kankal kaa utpaad haye aur calcium kii kamee key kaaran hoe sakata haye. haalaanki, chikitsak iss nishkarsh parr bhee aaa rahey hain kii bimari key vikas key charanon mein kaee tantra ack saath baatchit karate hain jisake parinamswarup umr kii parwah kiye binaa ack austeoporotic huddy hoti haye. phir bhee, bujurg loga duniya mein sabse teji seey badhati aabaadi banaate hain. jaise-jaise umr key saath huddy kaa dravyamaan cumm hotaa haye, asthibhang kaa khatra badh jaataa haye. austeoporotic fracture kii vaarshik ghatanaaen sanyukt raajya america mein 15 laakh seey adhik hain aur vishesh roop seey 20 pratishat loga koolhe key fracture key baad pahale varsh key dauran marr jaate hain.
2040 taka 50 arab dollar kii laagat key saath, americi swaasthya pranali kii laagat salana lagbhag 17 arab dollar haye. yeye laagat anya roga raajyon, jaise stun cancer, stroke, madhumeh yaa purani fefadon kii bimari kii tulanaa mein adhik bojh kaa pratinidhitva karati haye. halanki laagat prabhaavi aur achchi tarah seey sahan kiye jaane vaale upchaar hain, nidan kiye gaye 23 pratishat 67 seey adhik mahilaaon koo asthi khanij ghanatva (bmd) pareekshan yaa fracture key baad upchaar key liye purchy praapt hui haye. naidaanik aur aarthik bojh ingit karate hain kii austeoporosis kii baat aaney parr jokhim, roktham aur praarambhik hastakshep key mulyankan mein adhik prayaas honah chaahiye.
prastuti.
jatilataaen.
kyonki vriddhavastha austeoporosis umr badhane key kaaran huddy key dravyamaan key nuksan key kaaran hotaa haye, haddiyaan adhik najuk hoti hain aur iss prakaar fracture aur fracture seey sambandhit jatilataon key liye adhik pravan hoti hain. inn jatilataon mein bhavishya mein asthibhang key liye dogune seey adhik jokhim vriddhi aur deerghakaalik dard yaa vikalangata key parinamswarup jeevan kii nimn gunavatta shamil hoe sakati haye, kabhi-kabhi deerghakaalik nursing dekhbhal kii aavashyakta hoti haye. site key aadhar parr, pathologic fracture saapeksh mrityu darr key jokhim koo bhee badhaa sakate hain. akele koolhe key asthibhang vishesh roop seey kamjor karane vaale hotey hain aur asthibhang key ack varsh key bheetar mrityu darr lagbhag 20 pratishat adhik hoti haye. anya asthibhang adhik sookshm hotey hain aur kuchh samay key liye agyaat reh sakate hain. udaaharan key liye, reedh kii huddy mein kasheruki sampeedan fracture, joe aksar urdhvaadhar oonchaai key nuksan seey dhyaan dene yogya hotaa haye, mudanaa, khaansana aur pahunchana jaise niyamit gatiyon key dauran bhee hoe sakata haye.
huddy key khanij ghanatva mein kamee key alawa, aise anya kaarak hain joe asthibhang key jokhim mein yogdan karate hain jaise kii unnat ayu, cumm shareer dravyamaan soochkaank, asthibhang kaa itihas, dhumrapan, steroid kaa upayog, uchch sharaab kaa sevan, aur girawat kaa itihas. sharaab aur asthibhang key jokhim koo jodane vaale adhyayanon mein uchch sevan koo prati dinn teen yaa adhik peya key roop mein paribhaashit kiya gayaa haye. uchch caffein kaa sevan bhee asthibhang key jokhim mein bhoomika nibha sakata haye. kaee swaasthya sangathan ack asthibhang jokhim mulyankan upkaran (aff. aeye. aiks.) kaa bhee upayog karate hain joe kissy vyakti kii swaasthya jaankaari aur oopar soochibaddh maandandon key aadhar parr asthibhang honey kii 10 saal kii sambhavana kaa anuman lagaa sakata haye.
kaaran.
huddy kaa punarnirmaan, yaa huddy kaa avashoshan aur avashoshan, ack praakritik tantra haye joe shareer mein haddiyon kii marammat aur unhein majboot karane key liye hotaa haye. haalaanki, logon kii umr key saath-saath huddy key avashoshan aur gathan key beach ack asantulan hotaa haye, joe senile austeoporosis key vikas mein yogdan detaa haye. courtical aur trabacular haddiyon kii umr badhane seey vishesh roop seey bujurg aabaadi mein huddy key ghanatva mein kamee aatee haye. halanki vriddhavastha austeoporosis key sambandh mein adhikansh ateologic vichaar abhee taka chikitsakon key liye bahut spasht naheen hain, austeoporosis key jokhim karakon kii pehchaan kii gaee haye. inn karakon mein ling, umr, harmon asantulan, huddy kii gunavatta mein kamee aur huddy kii sookshm sanrachana kii akhandata mein kamee shamil haye.
naidaanik prayog seey judey vartamaan sakshya key aadhar parr, kuchh pramaan hain kii roga kaa rogjanan jastaa kii kamee seey sambandhit haye. iss tarah kii kamee seey antarjan heprin kii vriddhi hoti haye, joe sabse adhik sambhavana maast cell degrenulation key kaaran hoti haye, aur prostaglandin ee2 kii huddy key avashoshan (haddiyon mein calcium nirvahan) pratikriya mein vriddhi hoti haye, joe adhik huddy dravyamaan key gathan koo baadhit karati haye, jisase haddiyan adhik najuk hoe jaati hain. inn saha-karakon koo senile austeoporosis seey judee rogjanak prakriya mein ack mahatvapurna bhoomika nibhaate hue dikhaaya gayaa haye kyonki way parathyroid harmon kii kriya koo badhaate hain.
bujurg logon mein calcium kaa sevan kaafee cumm hotaa haye, aur ise khaane kii kshamata cumm honey seey yeh samasya aur kharaab hoe jaati haye. yeh, chayapachaya seey sambandhit vitamin dee key avashoshan mein kamee seey judaa huaa haye, yeye bhee aise kaarak hain joe austeoporosis prakaar II key nidan mein yogdan karate hain.
jokhim kaarak.
jabaki seeneel austeoporosis (prakaar II) mukhya roop seey umr key kaaran hotaa haye, anya jokhimon mein chikitsa, aushadhiya, aanuvanshik aur paryavaraniya kaarak shamil hain. huddy kaa dravyamaan huddy key ghanatva kaa ack pramukh nirdhaarak haye, joe garbhashay mein shuru hotaa haye aur aamtaur parr 40 varsh kii ayu taka puuraa hoe jaataa haye.
medical.
halanki austeoporosis key nidan key liye maadhyamik austeoporosis ack alag shreni haye, phir bhee yeh praathamik austeoporosis mein yogdan karane vaalaa kaarak hoe sakata haye. rajonivritti seey pahale aur baad kii mahilaaon aur purushon mein maadhyamik austeoporosis maujood hoe sakata haye aur donon lingon mein austeoporosis mein yogdan karane vaale kaarak paae gaye hain (purushon mein 50-80% aur rajonivritti key baad kii mahilaaon mein 30 pratishat). isaliye, jaba 70 seey adhik logon kaa ilaaj kiya jaataa haye, tou austeoporosis key maadhyamik karanon koo baahar karna mahatvapurna haye jisamen antahsraavi vikaar (ee.jee. atee-thyroid aur madhumeh), jathrantra sambandhi, yakrit sambandhi aur poshan sambandhi vikaar (jaise.jee. celiac roga aur soojan aantr roga), hematological vikaar (ee.jee. pranaaleegat mastocytosis), gurde key vikaar (ee.jee. purani gurde kii bimari), aur autoimmune vikaar (ee.jee. rheumatoid arthuritis aur systemic lupus erythematosus).
davaayen.
huddy key nuksan mein yogdan karane vaali davaaon mein aluminium (anticid mein paaya jaane vaalaa), aeromatase avarodhak, cyclosporin, dipo-medroxyprogesterone (premanopausal), glucocorticoids, lithium, proton pump avarodhak, serotonin reptech avarodhak, tachrolimus aur tamoxifen (premanopausal) shamil hain. yeye davaaen huddy key nuksan mein yogdan curr sakati hain aur austeoporotic fracture key liye jokhim badhaa sakati hain.
aanuvanshik.
maatri shareer kaa nirmaan, jeevan shally aur vitamin dee kii sthiti kuchh aanuvanshik aur epigenetic prabhaav hain joe bmd, vishesh roop seey vikasatmak plasticity koo prabhaavit karate paae gaye hain.
isake alawa, anya adhyayanon mein paaya gayaa haye kii nasl (ee.jee. ashwet mahilaaon koo sabse cumm jokhim hotaa haye), umr (i.ee. vriddhavastha), shareer dravyamaan (i.ee. cumm vajan), aur ling (mahila) austeoporosis key jokhim mein yogdan karane mein bhoomika nibhaate hain. haalaanki jansankhya samoohon key beach austeoporosis aur koolhe key fracture key vikas kii ghatanaaen bhinn hoti hain, lekin adhik umr lagaatar austeoporosis key kaaran fracture kii uchch ghatnaaon seey judee rahati haye.
samajik aur poshan kaarak.
kaee paryavaraniya aur samajik kaarak hain joe austeoporosis key vikas key jokhim mein yogdan curr sakate hain. tambaku kaa dhumrapan aant kii calcium avashoshit karane kii kshamata koo cumm karke jokhim badhaa sakata haye. caffein kaa sevan aur bhaari sharaab kaa bhee bujurg aabaadi mein huddy key ghanatva mein kamee key saath sambandh thaa.
vitamin dee aur calcium key uchit sevan key binaa, yeh bujurgon mein austeoporosis kaa khatra badhaa sakata haye. yeye vitamin kii kamee ack jokhim kaarak key roop mein pesh karati hain, kyonki yeh huddy key dravyamaan koo cumm curr sakati haye, calcium avashoshan koo cumm curr sakati haye, aur huddy key karobar mein vriddhi curr sakati haye. vibhinn davaaen bhee hain joe calcium key avashoshan mein hastakshep curr sakati hain, jaise kii anticonvalsant, mootravardhak, corticosteroids, immunospressive davaaen, kuchh antibiotic davaaen aur nsaid.
nidan.
kyonki austeoporosis kaa nidan kewal ack pathological fracture key baad kiya jaataa haye, isaliye uchch jokhim vaale vyaktiyon (bujurg) key liye kramik huddy ghanatva (jise huddy khanij ghanatva yaa bmd key roop mein bhee jaanaa jaataa haye) maap scan lena sabse achchha haye. vishva swaasthya sangathan (joe) ney bmd tii-score kaa upayog karke austeoporosis key liye ack naidaanik mandand sthaapit kiya haye joe sd kii sankhya key sandarbh mein ack vyakti key bmd kaa varnan kartaa haye joe yuva, swasth vyaktiyon mein ausat shikhar moolya seey alag haye. austeopania (cumm huddy dravyamaan) key liye seema ausat seey 1 aiss. dee. seey 2.5 aiss. dee. seey cumm haye. haalaanki, tii-score kaa upayog shuru mein aabaadi mein austeoporosis key prasaar key anuman key roop mein kiya gayaa thaa, naa kii vishisht vyaktiyon mein austeoporosis key prasaar kaa aaklan karane key liye joe rashtriya austeoporosis foundation aur naidaanik ghanatva key liye antarrashtriya samaaj key liye naidaanik ghanatva key liye hip aur/yaa reedh kii huddy key dohare-oorjaa aiks-ray avashoshan (dxa) kaa upayog karane parr vichaar karane key liye austeoporosis key pasandida maap key roop mein.
roktham.
oopar soochibaddh jokhimon mein seey, girane seey austeoporotic fracture kii ghatnaaon mein sabse mahatvapurna yogdan hotaa haye. niyamit vyayam kaa girane key jokhim koo cumm karane mein sabse majboot sambandh haye. peeth aur mudra vyayam jaise taaee chee key saath-saath chalane jaise vajan-wahan vyayam huddy key nuksan koo dheema curr sakate hain, santulan mein sudhaar curr sakate hain aur maanspeshiyon koo majboot curr sakate hain. girane key jokhim koo cumm karane key liye ghar parr bhee savdhani barati jaa sakati haye. inmein farsh parr raggon koo lunger dalna, avyavastha koo cumm karna, samagr prakaash aur drishyata mein sudhaar karna aur seedhiyon aur dalanon mein handle sthaapit karna shamil haye.
upchaar.
aahar yaa poorak seey calcium aur vitamin vitamin kaa sevan iss bimari key ethiopathogenesis mein mahatvapurna haye; isaliye, prabhaavi upchaaron mein gair-aushadhiya vidhiyaan (jaise kii adhik calcium 1000-1500 milligram/dinn aur vitamin vitamin key saath sanshodhit aahar 600-800 iu/dinn kaa sevan, vyayam, dhumrapan kii samaapti aur sharaab pratibandh), girawat kii roktham, aur vyaktigat roop seey chune gaye aushadhiya hastakshep (mahilaaon mein bisphosphanet yaa astrogen pratisthaapan chikitsa jaise antiresortive agent) shamil honey chaahiye. huddy kaa asthibhang (koolhe, kasheruka aur cole) koo dekhate hue austeoporosis kii ack vinashkari jatilata haye, vitamin vitamin kaa upayog calcium key saath praathamik roktham key roop mein kiya jaataa haye, saath hii saath alendronate, residronate, strontium aur zoldronic acid joe praathamik aur maadhyamik koolhe key asthibhang kii roktham mein prabhaavi saabit hue hain. chikitsa sansthaan 70 aur usase adhik umr key logon key liye 800 aaee. yuu. vitamin dee. key dainik bhatte kii sifarish kartaa haye, taaki cumm seey cumm 20 ng/ml (50 aine. moll/leater) key seeram 25-hydroxyvitamine dee dee key star taka pahunch sakey.
rajonivritti key baad kii mahila kii umr 65 parr 2008 seey aushadhiya agents kii ack vyavasthit sameeksha mein paaya gayaa kii bisphosphonets asthi majja ghanatva mein sudhaar aur placebo kii tulanaa mein kasheruki fracture mein kamee mein adhik prabhaavi hain. iss vyavasthit sameeksha mein yeh bhee paaya gayaa kii parathyroid harmon aur astrogen/progesterone therapy mein placebo kii tulanaa mein asthi majja ghanatva mein mahatvapurna sudhaar huaa thaa. bisphosphonets key alawa, austeoporosis key liye aushadhiya upchaaron mein calcitonin, parathyroid harmon 1-34, harmon pratisthaapan chikitsa aur monoclonal antibody chikitsa shamil hoe sakate hain. 2017 seey journal off american geriatrics society mein prakaashit ack anya vyavasthit sameeksha seey pataa chalaa kii austeoporotic fracture key jokhim vaale purushon mein, placebo kii tulanaa mein bisphosphonets mein fracture mein mahatvapurna kamee aaee thee, jabaki calcitonin aur monoclonal antibody therapy placebo kii tulanaa mein prabhavkarita naheen dikhaa paaee thee.
rajonivritti key baad kii badee mahilaaon mein, astrogen therapy (lekin cumm khuraak sanyugmit astrogen yaa ultra-low-khuraak astradiol naheen) nae kasheruki, gair-kasheruki aur koolhe key fracture kii ghatnaaon koo cumm curr sakati haye. chayanaatmak astrogen-receptor modulator jaise kii raloxifin koo austeoporosis key ilaaj key liye fda dwara anumodit kiya gayaa haye kyonki yeh huddy key avashoshan koo rokta haye, reedh kii huddy key bee. aim. dee. koo thodaa badhaata haye lekin antifracture gunon mein prabhaavi saabit naheen huaa haye.
yadyapi vriddhavastha austeoporosis mein jastaa dwara nibhai gaee bhoomika key kushal mulyankan key liye adhik adhyayan aavashyak hain, kuchh doctor calcium aur vitamin dee 3 key alawa aahar jastaa key uchit poorak kii sifarish curr sakate hain.

