text:
10mg/ml: Each ml of oral solution contains 10mg furosemide.
Each ml of solution contains 0.2ml liquid maltitol (E965) and 83.2mg ethanol (alcohol).
Clear, colourless, greenish yellow to pale brown coloured solution with cherry flavour.
Furosemide is indicated in all conditions requiring prompt diuresis in patients who are unable to take solid dose forms. Indications include cardiac, pulmonary, hepatic and renal oedema, peripheral oedema due to mechanical obstruction or venous insufficiency and hypertension.
The medication should be administered in the morning to avoid nocturnal diuresis.
The usual initial daily dose is 40mg. This may be adjusted until an effective dose is achieved.
In the elderly, furosemide is generally eliminated more slowly. Dosage should be titrated until the required response is achieved.
This product should not be used in children below 18 years of age (see section 4.4).
This product should not be mixed with food or beverages before use.
The syringe adaptor should be placed in the neck of the bottle and the required dose should be drawn from the container into the graduated oral syringe provided. The open end of the syringe should be placed in the mouth of the patient, and the piston slowly depressed to release the contents.
Hypovolaemia or dehydration. Anuria. Renal failure with anuria not responding to furosemide, or as a result of poisoning by nephrotoxic or hepatotoxic agents, or associated with hepatic coma. Severe hypokalaemia and severe hyponatraemia. Pre-comatose and comatose states associated with hepatic encephalopathy. Breast feeding.
Contra-indicated in hypersensitivity to Furosemide, sulphonamides or any of the excipients listed.
Patients allergic to sulphonamides may show cross-sensitivity to furosemide.
This product should not be given to children because its ethanol content may affect their CNS.
Caution is required in patients liable to electrolyte deficiency. Regular monitoring of serum sodium, potassium and creatinine is generally recommended during furosemide therapy; particularly close monitoring is required in patients at high risk of developing electrolyte imbalances or in case of significant additional fluid loss. Hypovolaemia or dehydration as well as any significant electrolyte and acid-base disturbances must be corrected. This may require temporary discontinuation of furosemide. Where indicated, steps should be taken to correct hypotension or hypovolaemia before commencing therapy.
Urinary output must be secured. Patients with partial obstructions of urinary outflow for example patients with prostatic hypertrophy or impairment of micturition have an increased risk of developing acute urinary retention and require careful monitoring.
• Patients with hypoproteinaemia, e.g. associated with nephrotic syndrome (the effect of furosemide may be weakened and its ototoxicity potentiated).
Symptomatic hypotension leading to dizziness, fainting or loss of consciousness can occur in patients treated with furosemide, particularly in the elderly, patients on other medications which can cause hypotension and patients with other medical conditions that are risks for hypotension.
The use of some diuretics is considered to be unsafe in acute porphyria therefore caution should be exercised.
Concomitant use with risperidone: In risperidone placebo-controlled trials in elderly patients with dementia, a higher incidence of mortality was observed in patients treated with furosemide plus risperidone (7.3%; mean age 89 years, range 75-97 years) when compared to patients treated with risperidone alone (3.1%; mean age 84 years, range 70-96 years) or furosemide alone (4.1%; mean age 80 years, range 67-90 years). Concomitant use of risperidone with other diuretics (mainly thiazide diuretics used in low dose) was not associated with similar findings.
No pathophysiological mechanism has been identified to explain this finding, and no consistent pattern for cause of death observed. Nevertheless, caution should be exercised and the risks and benefits of this combination or co-treatment with other potent diuretics should be considered prior to the decision to use. There was no increased incidence of mortality among patients taking other diuretics as concomitant treatment with risperidone. Irrespective of treatment, dehydration was an overall risk factor for mortality and should therefore be avoided in elderly patients with dementia (see section 4.3).
Furosemide is not recommended in patients at high risk for radiocontrast nephropathy - it should not be used for diuresis as part of the preventative measures against radiocontrast-induced nephropathy.
Ethanol (alcohol): Each ml of oral solution contains 83.2mg ethanol (alcohol) i.e daily dose of 40mg furosemide would include 332.8mg ethanol (alcohol), equivalent to 8.32ml of beer or 3.47ml of wine.
Harmful for those suffering from alcoholism. To be taken into account in pregnant or breast-feeding women and high-risk groups such as patients with liver disease, epilepsy. Because of its ethanol content this product should also not be given to children.
Liquid maltitol (E965): Patients with a rare hereditary problem of fructose intolerance should not take this medicine.
ACE Inhibitors: Enhanced hypotensive effect when given with diuretics. A marked fall in blood pressure and deterioration in renal function may be seen when ACE inhibitors are added to furosemide therapy. The dose of furosemide should be reduced for at least three days, or the drug stopped, before initiating the ACE inhibitor or increasing the dose of an ACE inhibitor.
Alpha-blockers: Enhanced hypotensive effect when diuretics are given with alpha-blockers, also increased risk of first dose hypotension with post-synaptic alpha-blockers such as prazosin.
Analgesics: Diuretics can increase the risk of nephrotoxicity of NSAIDs, also antagonism of diuretic effect. Antagonism of diuretic effect (especially with indomethacin and ketorolac). Salicylic toxicity may be increased by furosemide.
Angiotensin –II Receptor Antagonists: Enhanced hypotensive effect when diuretics given with angiotensin-II receptor antagonists.
Anti-arrhythmics: Hypokalaemia caused by loop diuretics increases cardiac toxicity with amiodarone, disopyramide, flecainide, and antagonises the action of lidocaine and mexiletine.
Antibacterials: Avoid the use of diuretics in lymecycline treatment. There is an increased risk of ototoxicity when loop diuretics are given with aminoglycosides, polymyxins or vancomycin. Since this may lead to irreversible damage, these drugs must only be used with furosemide if there are compelling medical reasons. Impairment of renal function may develop in patients receiving concurrent treatment with furosemide and high doses of certain cephalosporins.
Antidepressants: Possible increase of hypokalaemia when loop diuretics are given with reboxetine. There is an enhanced hypotensive effect when diuretics are given with MAOIs. There is an increased risk of postural hypotension when diuretics are given with tricyclic antidepressants.
Antiepileptics: There is an increased risk of hyponatraemia when diuretics are given with carbemazepine. The effects of furosemide are antagonised by phenytoin.
Antifungals: There is an increased risk of hypokalaemia when loop diuretics are given with amphotericin.
Antipsychotics: Hypokalaemia caused by diuretics increase the risk of ventricular arrhythmias with amisulpiride or sertindole. An enhanced hypotensive effect may be seen when diuretics are given with phenothiazines. Hypokalaemia caused by diuretics increases risk of ventricular arrhythmias with pimozide (avoid concomitant use).
Antivirals: Plasma concentration of diuretics may be increased by nelfinavir, ritonavir or saquinavir.
Atomoxetine: Hypokalaemia caused by diuretics increases the risk of ventricular arrhythmias with atomoxetine.
Barbiturates: Plasma concentrations of diuretics may be decreased. There may be an increased risk of osteomalacia when diuretics are taken in combination with Phenobarbital.
Beta-blockers: There is an enhanced hypotensive effect when diuretics are given with beta-blockers. Hypokalaemia caused by loop diuretics increases the risk of ventricular arrhythmias with sotalol.
Cardiac glycosides: Hypokalaemia caused by loop diuretics increases cardiac toxicity with cardiac glycosides.
Ciclosporin: there is an increased risk of nephrotoxicity and possibly hypermagnesaemia when diuretics are given with ciclosporin.
Cisplatin: There is a risk of increased ototoxic effects if cisplatin and furosemide are given concomitantly. In addition, nephrotoxicity of cisplatin may be enhanced if furosemide is not given in low doses (e.g. 40mg in patients with normal renal function) and with positive fluid balance when used to achieve forced diuresis during cisplatin treatment.
Corticosteroids: The diuretic effect of diuretics is antagonized by corticosteroids. There is an increased risk of hypokalaemia when loop diuretics are given with corticosteroids.
Other Diuretics: There is an increased risk of hypokalaemia when loop diuretics are given with acetazolamide. Profound diuresis is possible when metolazone is given with furosemide. There is an increased risk of hypokalaemia when loop diuretics are given with thiazides and related diuretics.
Lithium: Loop diuretics reduce the excretion of lithium, which may lead to increased plasma concentrations and a risk of toxicity. Therefore, it is recommended that lithium levels are carefully monitored and where necessary the lithium dosage is adjusted in patients receiving this combination.
Potassium salts: There is an increased risk of hyperkalaemia when given with potassium salts.
Sucralfate: Furosemide and sucralfate must not be taken within 2 hours of each other as sucralfate decreases the absorption of furosemide from the intestine and so reduces its effect.
Sympathomimetics, Beta2: There is an increased risk of hypokalameia when loop diuretics are given with high doses of beta2 synpathomimetics.
Tacrolimus: There is an increased risk of hypokalaemia when given with tacrolimus.
Theophylline: There is an increased risk of hypokalaemia when loop diuretics are given with theophylline.
Carbenoxolone, prolonged use of laxatives, liquorice: May increase the risk of developing hypokalaemia.
Warfarin and clofibrate: Warfarin and clofibrate compete with furosemide in the binding to serum albumin. This may have clinical significance in patients with low serum albumin levels (e.g. in nephrotic syndrome). Furosemide does not change the pharmacokinetics of warfarin to a significant extent, but a strong diuresis with associated dehydration may weaken the antithrombotic effect of warfarin.
Probenecid, methotrexate and other drugs which, like furosemide, undergo significant renal tubular secretion may reduce the effect of furosemide. Conversely, furosemide may decrease renal elimination of these drugs. In case of high-dose treatment (in particular, of both furosemide and the other drugs), this may lead to increased serum levels and an increased risk of adverse effects due to furosemide or the concomitant medication.
Risperidone: When administering risperidone, caution should be exercised and the risks and benefits of the combination or co-treatment with furosemide or with other potent diuretics should be considered prior to the decision to use. See section 4.4 Special warnings and precautions for use regarding increased mortality in elderly patients with dementia concomitantly receiving risperidone.
Results of animal work, in general, show no hazardous effect of furosemide in pregnancy. There is clinical evidence of safety of the drug in the third trimester of human pregnancy; however, furosemide crosses the placental barrier. It must not be given during pregnancy unless there are compelling medical reasons. Treatment during pregnancy requires monitoring of fetal growth.
Furosemide passes into breast milk and may inhibit lactation. Breastfeeding must be avoided during treatment with furosemide.
No human data on the effect of furosemide on fertility are available. In rats, there was no effect on mating or fertility with furosemide treatment.
Mental alertness may be reduced and the ability to drive or operate machinery may be impaired.
In general, if furosemide is administered to premature infants during the first weeks of life, it may increase the risk of persistence of patent ductus arteriosus. Risk of nephrocalcinosis/ nephroliathisis.
The clinical picture in acute or chronic overdose depends primarily on the extent and consequences of electrolyte and fluid loss, e.g. hypovolaemia, dehydration, haemoconcentration, cardiac arrhythmias – including A-V block and ventricular fibrillation. Symptoms of these disturbances include severe hypotension (progressing to shock), acute renal failure, thrombosis, delirious states, flaccid paralysis, apathy and confusion.
There are no specific antidotes to furosemide. If the ingestion is recent, attempts to limit further systemic absorption may be performed, through gastric lavage or others measures that may minimize absorption (i.e. activated charcoal).
The clinically relevant fluid and electrolyte balance changes must be corrected. Along with the prevention and treatment of serious complications resulting from such imbalances and other effects in the body, this corrective action may require general and specific intensive medical monitoring and therapeutic measures.
Furosemide is a potent loop diuretic which inhibits sodium and chloride reabsorption at the Loop of Henlé. The drug eliminates both positive and negative free water production. Furosemide acts at the luminal face of the epithelial cells by inhibiting co-transport mechanisms for the entry of sodium and chloride. Furosemide gains access to its site of action by being transported through the secretory pathway for organic acids in the proximal tubule. It reduces the renal excretion of uric acid. Furosemide causes an increased loss of potassium in the urine and also increases the excretion of ammonia by the kidney.
Furosemide is a weak carboxylic acid which exists mainly in the dissociated form in the gastro-intestinal tract. Furosemide is rapidly but incompletely absorbed (60-70%) on oral administration and its effect is largely over within four hours. The optimal absorption site is the upper duodenum at pH 5.0. Regardless of route of administration, 69-97% of activity from a radio-labelled dose is excreted in the first 4 hours after the drug is given. Furosemide is mainly eliminated via the kidneys (80-90%); a small fraction of the dose undergoes biliary elimination and 10-15% of the activity can be recovered from the faeces.
When oral doses of Furosemide are given to normal subjects the mean bioavailability of the drug is approximately 52% but the range is wide. In plasma, Furosemide is extensively bound to proteins mainly to albumin. The unbound fraction in plasma averages 2 - 4% at therapeutic concentrations. The volume of distribution ranges between 170 - 270ml/Kg. The half life of the ß phase ranges from 45 - 60 min. The total plasma clearance is about 200ml/min. Renal excretion of unchanged drug and elimination by metabolism plus faecal excretion contribute almost equally to the total plasma clearance. Furosemide is in part cleared by the kidneys in the form of the glucuronide conjugate.
Dosing Device: 10ml oral syringe with 0.5ml graduation mark supplied with an LDPE syringe adaptor.

tokenized:
10mg / ml : Each ml of oral solution contains 10 mg furosemide .
 Each ml of solution contains 0.2ml liquid maltitol ( E965 ) and 83.2 mg ethanol ( alcohol ) .
 Clear , colourless , greenish yellow to pale brown coloured solution with cherry flavour .
 Furosemide is indicated in all conditions requiring prompt diuresis in patients who are unable to take solid dose forms . Indications include cardiac , pulmonary , hepatic and renal oedema , peripheral oedema due to mechanical obstruction or venous insufficiency and hypertension .
 The medication should be administered in the morning to avoid nocturnal diuresis .
 The usual initial daily dose is 40 mg . This may be adjusted until an effective dose is achieved .
 In the elderly , furosemide is generally eliminated more slowly . Dosage should be titrated until the required response is achieved .
 This product should not be used in children below 18 years of age ( see section 4.4 ) .
 This product should not be mixed with food or beverages before use .
 The syringe adaptor should be placed in the neck of the bottle and the required dose should be drawn from the container into the graduated oral syringe provided . The open end of the syringe should be placed in the mouth of the patient , and the piston slowly depressed to release the contents .
 Hypovolaemia or dehydration . Anuria . Renal failure with anuria not responding to furosemide , or as a result of poisoning by nephrotoxic or hepatotoxic agents , or associated with hepatic coma . Severe hypokalaemia and severe hyponatraemia . Pre - comatose and comatose states associated with hepatic encephalopathy . Breast feeding .
 Contra - indicated in hypersensitivity to Furosemide , sulphonamides or any of the excipients listed .
 Patients allergic to sulphonamides may show cross - sensitivity to furosemide .
 This product should not be given to children because its ethanol content may affect their CNS .
 Caution is required in patients liable to electrolyte deficiency . Regular monitoring of serum sodium , potassium and creatinine is generally recommended during furosemide therapy ; particularly close monitoring is required in patients at high risk of developing electrolyte imbalances or in case of significant additional fluid loss . Hypovolaemia or dehydration as well as any significant electrolyte and acid - base disturbances must be corrected . This may require temporary discontinuation of furosemide . Where indicated , steps should be taken to correct hypotension or hypovolaemia before commencing therapy .
 Urinary output must be secured . Patients with partial obstructions of urinary outflow for example patients with prostatic hypertrophy or impairment of micturition have an increased risk of developing acute urinary retention and require careful monitoring .
 • Patients with hypoproteinaemia , e.g. associated with nephrotic syndrome ( the effect of furosemide may be weakened and its ototoxicity potentiated ) .
 Symptomatic hypotension leading to dizziness , fainting or loss of consciousness can occur in patients treated with furosemide , particularly in the elderly , patients on other medications which can cause hypotension and patients with other medical conditions that are risks for hypotension .
 The use of some diuretics is considered to be unsafe in acute porphyria therefore caution should be exercised .
 Concomitant use with risperidone : In risperidone placebo - controlled trials in elderly patients with dementia , a higher incidence of mortality was observed in patients treated with furosemide plus risperidone ( 7.3 % ; mean age 89 years , range 75 - 97 years ) when compared to patients treated with risperidone alone ( 3.1 % ; mean age 84 years , range 70 - 96 years ) or furosemide alone ( 4.1 % ; mean age 80 years , range 67 - 90 years ) . Concomitant use of risperidone with other diuretics ( mainly thiazide diuretics used in low dose ) was not associated with similar findings .
 No pathophysiological mechanism has been identified to explain this finding , and no consistent pattern for cause of death observed . Nevertheless , caution should be exercised and the risks and benefits of this combination or co - treatment with other potent diuretics should be considered prior to the decision to use . There was no increased incidence of mortality among patients taking other diuretics as concomitant treatment with risperidone . Irrespective of treatment , dehydration was an overall risk factor for mortality and should therefore be avoided in elderly patients with dementia ( see section 4.3 ) .
 Furosemide is not recommended in patients at high risk for radiocontrast nephropathy - it should not be used for diuresis as part of the preventative measures against radiocontrast - induced nephropathy .
 Ethanol ( alcohol ): Each ml of oral solution contains 83.2 mg ethanol ( alcohol ) i.e daily dose of 40 mg furosemide would include 332.8 mg ethanol ( alcohol ) , equivalent to 8.32ml of beer or 3.47ml of wine .
 Harmful for those suffering from alcoholism . To be taken into account in pregnant or breast - feeding women and high - risk groups such as patients with liver disease , epilepsy . Because of its ethanol content this product should also not be given to children .
 Liquid maltitol ( E965 ): Patients with a rare hereditary problem of fructose intolerance should not take this medicine .
 ACE Inhibitors : Enhanced hypotensive effect when given with diuretics . A marked fall in blood pressure and deterioration in renal function may be seen when ACE inhibitors are added to furosemide therapy . The dose of furosemide should be reduced for at least three days , or the drug stopped , before initiating the ACE inhibitor or increasing the dose of an ACE inhibitor .
 Alpha - blockers : Enhanced hypotensive effect when diuretics are given with alpha - blockers , also increased risk of first dose hypotension with post - synaptic alpha - blockers such as prazosin .
 Analgesics : Diuretics can increase the risk of nephrotoxicity of NSAIDs , also antagonism of diuretic effect . Antagonism of diuretic effect ( especially with indomethacin and ketorolac ) . Salicylic toxicity may be increased by furosemide .
 Angiotensin – II Receptor Antagonists : Enhanced hypotensive effect when diuretics given with angiotensin - II receptor antagonists .
 Anti - arrhythmics : Hypokalaemia caused by loop diuretics increases cardiac toxicity with amiodarone , disopyramide , flecainide , and antagonises the action of lidocaine and mexiletine .
 Antibacterials : Avoid the use of diuretics in lymecycline treatment . There is an increased risk of ototoxicity when loop diuretics are given with aminoglycosides , polymyxins or vancomycin . Since this may lead to irreversible damage , these drugs must only be used with furosemide if there are compelling medical reasons . Impairment of renal function may develop in patients receiving concurrent treatment with furosemide and high doses of certain cephalosporins .
 Antidepressants : Possible increase of hypokalaemia when loop diuretics are given with reboxetine . There is an enhanced hypotensive effect when diuretics are given with MAOIs . There is an increased risk of postural hypotension when diuretics are given with tricyclic antidepressants .
 Antiepileptics : There is an increased risk of hyponatraemia when diuretics are given with carbemazepine . The effects of furosemide are antagonised by phenytoin .
 Antifungals : There is an increased risk of hypokalaemia when loop diuretics are given with amphotericin .
 Antipsychotics : Hypokalaemia caused by diuretics increase the risk of ventricular arrhythmias with amisulpiride or sertindole . An enhanced hypotensive effect may be seen when diuretics are given with phenothiazines . Hypokalaemia caused by diuretics increases risk of ventricular arrhythmias with pimozide ( avoid concomitant use ) .
 Antivirals : Plasma concentration of diuretics may be increased by nelfinavir , ritonavir or saquinavir .
 Atomoxetine : Hypokalaemia caused by diuretics increases the risk of ventricular arrhythmias with atomoxetine .
 Barbiturates : Plasma concentrations of diuretics may be decreased . There may be an increased risk of osteomalacia when diuretics are taken in combination with Phenobarbital .
 Beta - blockers : There is an enhanced hypotensive effect when diuretics are given with beta - blockers . Hypokalaemia caused by loop diuretics increases the risk of ventricular arrhythmias with sotalol .
 Cardiac glycosides : Hypokalaemia caused by loop diuretics increases cardiac toxicity with cardiac glycosides .
 Ciclosporin : there is an increased risk of nephrotoxicity and possibly hypermagnesaemia when diuretics are given with ciclosporin .
 Cisplatin : There is a risk of increased ototoxic effects if cisplatin and furosemide are given concomitantly . In addition , nephrotoxicity of cisplatin may be enhanced if furosemide is not given in low doses ( e.g. 40 mg in patients with normal renal function ) and with positive fluid balance when used to achieve forced diuresis during cisplatin treatment .
 Corticosteroids : The diuretic effect of diuretics is antagonized by corticosteroids . There is an increased risk of hypokalaemia when loop diuretics are given with corticosteroids .
 Other Diuretics : There is an increased risk of hypokalaemia when loop diuretics are given with acetazolamide . Profound diuresis is possible when metolazone is given with furosemide . There is an increased risk of hypokalaemia when loop diuretics are given with thiazides and related diuretics .
 Lithium : Loop diuretics reduce the excretion of lithium , which may lead to increased plasma concentrations and a risk of toxicity . Therefore , it is recommended that lithium levels are carefully monitored and where necessary the lithium dosage is adjusted in patients receiving this combination .
 Potassium salts : There is an increased risk of hyperkalaemia when given with potassium salts .
 Sucralfate : Furosemide and sucralfate must not be taken within 2 hours of each other as sucralfate decreases the absorption of furosemide from the intestine and so reduces its effect .
 Sympathomimetics , Beta2 : There is an increased risk of hypokalameia when loop diuretics are given with high doses of beta2 synpathomimetics .
 Tacrolimus : There is an increased risk of hypokalaemia when given with tacrolimus .
 Theophylline : There is an increased risk of hypokalaemia when loop diuretics are given with theophylline .
 Carbenoxolone , prolonged use of laxatives , liquorice : May increase the risk of developing hypokalaemia .
 Warfarin and clofibrate : Warfarin and clofibrate compete with furosemide in the binding to serum albumin . This may have clinical significance in patients with low serum albumin levels ( e.g. in nephrotic syndrome ) . Furosemide does not change the pharmacokinetics of warfarin to a significant extent , but a strong diuresis with associated dehydration may weaken the antithrombotic effect of warfarin .
 Probenecid , methotrexate and other drugs which , like furosemide , undergo significant renal tubular secretion may reduce the effect of furosemide . Conversely , furosemide may decrease renal elimination of these drugs . In case of high - dose treatment ( in particular , of both furosemide and the other drugs ) , this may lead to increased serum levels and an increased risk of adverse effects due to furosemide or the concomitant medication .
 Risperidone : When administering risperidone , caution should be exercised and the risks and benefits of the combination or co - treatment with furosemide or with other potent diuretics should be considered prior to the decision to use . See section 4.4 Special warnings and precautions for use regarding increased mortality in elderly patients with dementia concomitantly receiving risperidone .
 Results of animal work , in general , show no hazardous effect of furosemide in pregnancy . There is clinical evidence of safety of the drug in the third trimester of human pregnancy ; however , furosemide crosses the placental barrier . It must not be given during pregnancy unless there are compelling medical reasons . Treatment during pregnancy requires monitoring of fetal growth .
 Furosemide passes into breast milk and may inhibit lactation . Breastfeeding must be avoided during treatment with furosemide .
 No human data on the effect of furosemide on fertility are available . In rats , there was no effect on mating or fertility with furosemide treatment .
 Mental alertness may be reduced and the ability to drive or operate machinery may be impaired .
 In general , if furosemide is administered to premature infants during the first weeks of life , it may increase the risk of persistence of patent ductus arteriosus . Risk of nephrocalcinosis/ nephroliathisis .
 The clinical picture in acute or chronic overdose depends primarily on the extent and consequences of electrolyte and fluid loss , e.g. hypovolaemia , dehydration , haemoconcentration , cardiac arrhythmias – including A - V block and ventricular fibrillation . Symptoms of these disturbances include severe hypotension ( progressing to shock ) , acute renal failure , thrombosis , delirious states , flaccid paralysis , apathy and confusion .
 There are no specific antidotes to furosemide . If the ingestion is recent , attempts to limit further systemic absorption may be performed , through gastric lavage or others measures that may minimize absorption ( i.e. activated charcoal ) .
 The clinically relevant fluid and electrolyte balance changes must be corrected . Along with the prevention and treatment of serious complications resulting from such imbalances and other effects in the body , this corrective action may require general and specific intensive medical monitoring and therapeutic measures .
 Furosemide is a potent loop diuretic which inhibits sodium and chloride reabsorption at the Loop of Henlé . The drug eliminates both positive and negative free water production . Furosemide acts at the luminal face of the epithelial cells by inhibiting co - transport mechanisms for the entry of sodium and chloride . Furosemide gains access to its site of action by being transported through the secretory pathway for organic acids in the proximal tubule . It reduces the renal excretion of uric acid . Furosemide causes an increased loss of potassium in the urine and also increases the excretion of ammonia by the kidney .
 Furosemide is a weak carboxylic acid which exists mainly in the dissociated form in the gastro - intestinal tract . Furosemide is rapidly but incompletely absorbed ( 60 - 70 % ) on oral administration and its effect is largely over within four hours . The optimal absorption site is the upper duodenum at pH 5.0 . Regardless of route of administration , 69 - 97 % of activity from a radio - labelled dose is excreted in the first 4 hours after the drug is given . Furosemide is mainly eliminated via the kidneys ( 80 - 90 % ) ; a small fraction of the dose undergoes biliary elimination and 10 - 15 % of the activity can be recovered from the faeces .
 When oral doses of Furosemide are given to normal subjects the mean bioavailability of the drug is approximately 52 % but the range is wide . In plasma , Furosemide is extensively bound to proteins mainly to albumin . The unbound fraction in plasma averages 2 - 4 % at therapeutic concentrations . The volume of distribution ranges between 170 - 270ml / Kg . The half life of the ß phase ranges from 45 - 60 min . The total plasma clearance is about 200ml / min . Renal excretion of unchanged drug and elimination by metabolism plus faecal excretion contribute almost equally to the total plasma clearance . Furosemide is in part cleared by the kidneys in the form of the glucuronide conjugate .
 Dosing Device : 10ml oral syringe with 0.5ml graduation mark supplied with an LDPE syringe adaptor .


text:
MACON, Ill. – Griz FM 98.1 Fan Appreciation Night features the State Street Stocks Championship and the Big Ten Series Street Stocks Championship, but the fun doesn’t stop here at legendary Macon Speedway Saturday. With general admission for ladies only $6 on Bud Light Ladies Night and the gals racing from Pop’s Place plus racing in six classes on the fifth-mile high banked oval, it’s a great night to head to the famed speedway on the holiday weekend.
As of 1 p.m. Saturday, preparations were underway for racing at Macon Speedway. Check Maconracing.com for further updates throughout the day.
The Midwest Big Ten Series Street Stocks will bring some fireworks to an already competitive class. With the $1,000 prize for the season championship up for grabs, the $500 to win feature race, a dash for cash, some trophies on the line and qualifying for the dirt stock cars, it’s the biggest Street stocks event in the state this season. Terry Reed of Decatur and Bobby Beiler of Blue Mound battle for the championship, and the points fund payout extends through the top 10. There’s plenty of places up for grabs with a driver’s top eight finishes counting toward his Big Ten Series points total.
Bud Light Ladies Night presented by Y103 features the ladies from Pop’s Place as they hop into 4-cylinder Hornets in an effort to advance to the Bud Light Ladies Night finals in September. Michelle Perry, Karey Keller, Genny Hinton, Christine Vogel and Stephanie Keenan will attempt to join Jenny Cramer and Dana Damery of Rocco’s, Dawn Reynolds and Holly Vinson of Starship Billiards and Laurel Phipps and Brianna Livingston of Woody’s in the Bud Light Ladies Night Championship on Sept. 13. So with that many women heading to Macon Speedway, it’s a great time for the guys to make sure they get here and grab some Buds.

tokenized:
MACON , Ill. – Griz FM 98.1 Fan Appreciation Night features the State Street Stocks Championship and the Big Ten Series Street Stocks Championship , but the fun does n’t stop here at legendary Macon Speedway Saturday . With general admission for ladies only $ 6 on Bud Light Ladies Night and the gals racing from Pop ’s Place plus racing in six classes on the fifth - mile high banked oval , it ’s a great night to head to the famed speedway on the holiday weekend .
 As of 1 p.m. Saturday , preparations were underway for racing at Macon Speedway . Check Maconracing.com for further updates throughout the day .
 The Midwest Big Ten Series Street Stocks will bring some fireworks to an already competitive class . With the $ 1,000 prize for the season championship up for grabs , the $ 500 to win feature race , a dash for cash , some trophies on the line and qualifying for the dirt stock cars , it ’s the biggest Street stocks event in the state this season . Terry Reed of Decatur and Bobby Beiler of Blue Mound battle for the championship , and the points fund payout extends through the top 10 . There ’s plenty of places up for grabs with a driver ’s top eight finishes counting toward his Big Ten Series points total .
 Bud Light Ladies Night presented by Y103 features the ladies from Pop ’s Place as they hop into 4 - cylinder Hornets in an effort to advance to the Bud Light Ladies Night finals in September . Michelle Perry , Karey Keller , Genny Hinton , Christine Vogel and Stephanie Keenan will attempt to join Jenny Cramer and Dana Damery of Rocco ’s , Dawn Reynolds and Holly Vinson of Starship Billiards and Laurel Phipps and Brianna Livingston of Woody ’s in the Bud Light Ladies Night Championship on Sept. 13 . So with that many women heading to Macon Speedway , it ’s a great time for the guys to make sure they get here and grab some Buds .


text:
Sentiments/Non-Humans: Mostly indifferent, sees most human-like D-bees as just another human, still can't help but stare at D-bees that are very different/alien.
Sentiments/Coalition: Thinks of them as stuck up at best, no matter what his superiors and the government say.
Disposition: Generally friendly sort of fellow, hangs out with the rest of the squad when off duty. On-duty he takes his job seriously, though he is not the by-the-book sort and will bend or out-right break the rules if the situation calls for it.
Description: Athletic, wiry build, green eyes, black hair that is long on the top and pulled back into a warriors knot and shaved on the sides, also has a fair number of tattoos across his back, chest, & arms. These tattoos are a collage of power armor suits and robot vehicles from every manufacturer that sells these types of units in North America with steam-punk designs tying the individual pieces together.
Max. Carrying Weight: 250 lbs.
Max. Lifting Weight: 500 lbs.
Triple Damage against Robots when a "natural," unmodified 18, 19 or 20 is rolled on an Aimed Shot. This applies only to robots and not power armor exoskeletons.
armor, vehicles and robot vehicles by 5%.
Spiritual and Determined: +2d4 to M.E.
Spiritual and Determined: Inner Strength; has additional P.P.E. and can use TW items.
Agile and Dexterous: +2d4 to P.P.
Agile and Dexterous: Ambidextrous trait; Can use both the right and left hand with equal skill and dexterity; Paired Weapons skill is automatic. +1 APM, +10% to Climbing skills, +5% to Pick Locks, Pick Pockets, Palming, and Concealment skills.
Cannot be surprised, even from behind.
W.P. - Sharpshooting: Handgun; +1 attack per melee, Aimed: +3 strike, Called: +5 strike, Quick Draw: +4 initiative, Trick Shooting: Dodge, roll, or somersault and come up shooting, these are in addition to W.P. - Handgun bonuses.
Last edited by Victor Singer on Mon Oct 22, 2018 3:16 pm, edited 66 times in total.
NG-X67 "Prophet" Infantry Power Armor - "Milashka"
* -4 to strike on a called shot, and must be a Called shot.
** Depleting the Main Body of MDC will shut the suit down.
*** Force field regenerates at a rate of 1 MDC/melee round.
Cat-like landings from heights: up to 200' without damage.
Criminal I.D. Recognition System; Is programmed with 250,000 known criminals, wanted fugitives, Black Marketeers, terrorists, enemies of the state, bounties, identifying markings, known gang emblems, symbols, emblems, patches, & colors.
Advanced Camera; this is mounted in the helmet has and has superior telescopic zoom (Range: 2 miles) and a macro-lens (x12 magnification), it can take stills & video (96 hours & 8,000 images), and it can be transmitted live (Range: 5 miles).
Digital Dash-Cams (8); two in the helmet, 2 in the chest, 1 in each forearm, 2 in the back w 48 hours of record time & can take 4,000 stills.
Peekaboo Cameras (2); located behind the left & right shoulders, can be used to peak around corners or through foliage without exposing oneself.
Special & Standard Helmet Optics; Passive night-vision, Thermal imaging, IR, UV, black-light, laser distancer, IR light, & voice modulation (20 variations).
Warning System & Multi-Cameras; Tied into the cameras & sensor array is a motion detection warning system that gives an audible voice warning/notification when the system picks up or spots something notable within 100'. This includes not only incoming fire or danger, direction, distance, but also subjects picked up by the Criminal I.D. System meaning it will give information about said subject as well, at least info it has in its files. This is basic info like name, race, friendly/hostile, or gang/group affiliation.
Note: Used, has only 65 MDC, -5% Prowl (only to prowl, other movement is fine). A skilled operator could repair the suit to bring it to full MDC, but it would take double normal time. The Prowl penalty can be removed by redoing the fabric lining of the suit. What Victor didn't notice is that the legs have some bad repair to the fabric lining, it crinkles and cracks as the wearer moves. What he did notice is that the suit has been outfitted with four concealed pockets. One on the back is useful for a medium or smaller handgun. Two are on the inside of thighs are are suitable for hiding papers or the like (such as maps). The third is on the inside of the chest, it's only accessible when the suit is off. It can hold a larger volume of flat stuff compared to the thighs.
• Mega-Damage: 2d4 M.D. or 4d6 M.D.
• Mega-Damage: 3d6 M.D. or 1d4x10 M.D.
• Weapons: None built in.
• Note: May overheat if used continuously for more than four hours (01-40%). Overheating will destroy the machine; should be allowed to cool for two hours after every two or three hours of continuous use.
Note: Used, has only 28 MDC, gets only 750 miles per charge, 12 years old. Otherwise in great working order. It would take rebuilding the housing almost completely to get the MDC back. Installing a new battery would restore the range to 800 miles.
The brain child of the KLS corporation, this rail gun design is a miniaturized version of the RG-14 Electromagnetic Mass Driver. It's flexibility, efficiency, and relatively light weight make it the most potent man-portable, anti-armor & anti-demon weapon system ever produced. The only drawback is the delay in discharge as the capacitors spool up to release the hypersonic sabot payload. Several cases of these rifles have been released for field testing.
Helical magazines must be custom made by highly skilled weapons shops and have a base cost of 1000 credits each.
APDS rounds must be custom made by highly skilled weapons shops and have a base cost of 250 credits each.
two sets of street clothes, pocket flashlight, tinted goggles, small digital photo album that has pictures of his family & friends, box of disposable plastic gloves (100 per box), three weeks of freeze-dried combat rations, duffle bag, air filter, 2-person tent, hunting & fishing kit, 30' of lightweight climbing rope, survival knife, small hatchet, short range radio, Hard-shell backpack from NG-X67.
Damage: 5d6+3 or 3d4x10 M.D.
Payload: 240 shots using a portable generator, which regenerates 8 shots per hour. Can also be directly linked to a vehicles power supply (Nuclear or Solid-Ox) giving it a virtually unlimited payload.
Weight: Laser cannon - 40 lbs., Portable generator - 30 lbs.
Last edited by Victor Singer on Mon Oct 22, 2018 3:40 pm, edited 47 times in total.
Victor Calvin Singer was born to Robert and Karen Singer, he also has a sister named Christine who is just a year younger. His family lives in the Manistique Imperium where Victor was raised. His father works in a Northern Gun assembly plant that just so happens to turn out final assemblies of robot vehicles and power armor suits, interestingly enough his sister also works at the plant these days, though she began there after Victor left for the Army. From an early age he was fascinated by the robot vehicles and power armor that has dad built. Mainly it was the smaller power armor suits that caught his attention, how a soldier could go into combat in such a suit and take out a much larger, more heavily armored robot or a 20’ tall supernatural monster was exciting to him. So, when he turned 18 it seemed only natural that he join the Army and apply to be a PA pilot. With his reflexes plus his almost obsessive knowledge of power armor, he became an excellent soldier…at least on paper and tests.
Somehow, during his 4 years of service, Victor was always assigned or re-assigned to a unit that was in the single most boring and inactive post. He has been in only 4 minor fire fights and even than his squad was either on mop-up duty or just on standby in case things went sideways. So, once his 4 years of enlistment was up, Victor applied for private military contractor status, purchased a Blue Boy power suit and moved on. He has done half a dozen solo jobs, but he’s found it is much more difficult to carry out a mission when you don’t have a squad at your back. This lead him to contact some old friends back home about any work they might know of. One friend in particular responded, Mindy Corsair. She in turn suggested he get hold of Emerald Ecks and after a long conversation about her brother Royal and his...life lessons...Emerald convinced Victor to reach out to Royal. Apparently her brother had for some time now been running a mercenary unit out of MercTown and she thought they might be hiring. Victor has misgivings about Royal, as he wasn't the nicest guy when they were kids, but Victor knows and trusts both Emerald and Mindy. In particular Mindy's word means most to him since she was not a fan of Royal when they were younger...now she seems to be genuinely proud of the guy. Victor figures it couldn't hurt to go and meet up with Royal and see what is what. So, he contacted Royal and the two set up a meet in MercTown. Now, looking at the city of MercTown from a nearby hilltop, Victor hopes his trek here means work...preferably paying work.
Last edited by Victor Singer on Sat Jun 04, 2016 10:36 am, edited 6 times in total.
Used T-42 Commando = 38,000 (pg. 38 of Triax & NGR) Note: Has only 45 MDC, -5% Prowl (only to prowl, other movement is fine). What Victor didn't notice is that the legs have some bad repair to the fabric lining, it crinkles and cracks as the wearer moves. What he did notice is that the suit has been outfitted with four concealed pockets. One on the back is useful for a medium or smaller handgun. Two are on the inside of thighs are are suitable for hiding papers or the like (such as maps). The third is on the inside of the chest, it's only accessible when the suit is off. It can hold a larger volume of flat stuff compared to the thighs.
Used NG-WJ10 Speedpack (electric) = 28,000 (pg. 193 of Northern Gun 2) Note: Has only 28 MDC, gets only 750 miles per charge, 12 years old. Otherwise in great working order. It would take rebuilding the housing almost completely to get the MDC back. Installing a new battery would restore the range to 800 miles.
Victor will look over several junkyards for this and will ask each of the owners to keep an eye out for the launcher or see if any of them will place an order for one, so to speak.
None are available. Most of the dealers in Merctown are unfamiliar with the NGR military hardware. The Super Trooper is rare outside the military even in Europe. By the third junkyard the dealer tells Victor he got a call from Kraus telling him to not deal with Victor.
1d8 = 4: Receive a +2D6 Attribute Boost to P.S.
(1) Receive a +2D4 Attribute Boost to M.E.
+2d4 = 4 to M.E.
+1d4 = 3x10=30 to P.P.E.
NOTE: No point in rolling the sub table on the next two, since both are on the same sub-table and Victor already has 2 of the 4 on said sub-table.
(1) Receive a +2D4 Attribute Boost to P.P.

tokenized:
Sentiments / Non - Humans : Mostly indifferent , sees most human - like D - bees as just another human , still ca n't help but stare at D - bees that are very different / alien .
 Sentiments / Coalition : Thinks of them as stuck up at best , no matter what his superiors and the government say .
 Disposition : Generally friendly sort of fellow , hangs out with the rest of the squad when off duty . On - duty he takes his job seriously , though he is not the by - the - book sort and will bend or out - right break the rules if the situation calls for it .
 Description : Athletic , wiry build , green eyes , black hair that is long on the top and pulled back into a warriors knot and shaved on the sides , also has a fair number of tattoos across his back , chest , & arms . These tattoos are a collage of power armor suits and robot vehicles from every manufacturer that sells these types of units in North America with steam - punk designs tying the individual pieces together .
 Max . Carrying Weight : 250 lbs .
 Max . Lifting Weight : 500 lbs .
 Triple Damage against Robots when a " natural , " unmodified 18 , 19 or 20 is rolled on an Aimed Shot . This applies only to robots and not power armor exoskeletons .
 armor , vehicles and robot vehicles by 5 % .
 Spiritual and Determined : +2d4 to M.E.
 Spiritual and Determined : Inner Strength ; has additional P.P.E. and can use TW items .
 Agile and Dexterous : +2d4 to P.P.
 Agile and Dexterous : Ambidextrous trait ; Can use both the right and left hand with equal skill and dexterity ; Paired Weapons skill is automatic . +1 APM , +10 % to Climbing skills , +5 % to Pick Locks , Pick Pockets , Palming , and Concealment skills .
 Can not be surprised , even from behind .
 W.P. - Sharpshooting : Handgun ; +1 attack per melee , Aimed : +3 strike , Called : +5 strike , Quick Draw : +4 initiative , Trick Shooting : Dodge , roll , or somersault and come up shooting , these are in addition to W.P. - Handgun bonuses .
 Last edited by Victor Singer on Mon Oct 22 , 2018 3:16 pm , edited 66 times in total .
 NG - X67 " Prophet " Infantry Power Armor - " Milashka "
 * -4 to strike on a called shot , and must be a Called shot .
 * * Depleting the Main Body of MDC will shut the suit down .
 * * * Force field regenerates at a rate of 1 MDC / melee round .
 Cat - like landings from heights : up to 200 ' without damage .
 Criminal I.D. Recognition System ; Is programmed with 250,000 known criminals , wanted fugitives , Black Marketeers , terrorists , enemies of the state , bounties , identifying markings , known gang emblems , symbols , emblems , patches , & colors .
 Advanced Camera ; this is mounted in the helmet has and has superior telescopic zoom ( Range : 2 miles ) and a macro - lens ( x12 magnification ) , it can take stills & video ( 96 hours & 8,000 images ) , and it can be transmitted live ( Range : 5 miles ) .
 Digital Dash - Cams ( 8) ; two in the helmet , 2 in the chest , 1 in each forearm , 2 in the back w 48 hours of record time & can take 4,000 stills .
 Peekaboo Cameras ( 2 ) ; located behind the left & right shoulders , can be used to peak around corners or through foliage without exposing oneself .
 Special & Standard Helmet Optics ; Passive night - vision , Thermal imaging , IR , UV , black - light , laser distancer , IR light , & voice modulation ( 20 variations ) .
 Warning System & Multi - Cameras ; Tied into the cameras & sensor array is a motion detection warning system that gives an audible voice warning / notification when the system picks up or spots something notable within 100 ' . This includes not only incoming fire or danger , direction , distance , but also subjects picked up by the Criminal I.D. System meaning it will give information about said subject as well , at least info it has in its files . This is basic info like name , race , friendly / hostile , or gang / group affiliation .
 Note : Used , has only 65 MDC , -5 % Prowl ( only to prowl , other movement is fine ) . A skilled operator could repair the suit to bring it to full MDC , but it would take double normal time . The Prowl penalty can be removed by redoing the fabric lining of the suit . What Victor did n't notice is that the legs have some bad repair to the fabric lining , it crinkles and cracks as the wearer moves . What he did notice is that the suit has been outfitted with four concealed pockets . One on the back is useful for a medium or smaller handgun . Two are on the inside of thighs are are suitable for hiding papers or the like ( such as maps ) . The third is on the inside of the chest , it 's only accessible when the suit is off . It can hold a larger volume of flat stuff compared to the thighs .
 • Mega - Damage : 2d4 M.D. or 4d6 M.D.
 • Mega - Damage : 3d6 M.D. or 1d4x10 M.D.
 • Weapons : None built in .
 • Note : May overheat if used continuously for more than four hours ( 01 - 40 % ) . Overheating will destroy the machine ; should be allowed to cool for two hours after every two or three hours of continuous use .
 Note : Used , has only 28 MDC , gets only 750 miles per charge , 12 years old . Otherwise in great working order . It would take rebuilding the housing almost completely to get the MDC back . Installing a new battery would restore the range to 800 miles .
 The brain child of the KLS corporation , this rail gun design is a miniaturized version of the RG-14 Electromagnetic Mass Driver . It 's flexibility , efficiency , and relatively light weight make it the most potent man - portable , anti - armor & anti - demon weapon system ever produced . The only drawback is the delay in discharge as the capacitors spool up to release the hypersonic sabot payload . Several cases of these rifles have been released for field testing .
 Helical magazines must be custom made by highly skilled weapons shops and have a base cost of 1000 credits each .
 APDS rounds must be custom made by highly skilled weapons shops and have a base cost of 250 credits each .
 two sets of street clothes , pocket flashlight , tinted goggles , small digital photo album that has pictures of his family & friends , box of disposable plastic gloves ( 100 per box ) , three weeks of freeze - dried combat rations , duffle bag , air filter , 2 - person tent , hunting & fishing kit , 30 ' of lightweight climbing rope , survival knife , small hatchet , short range radio , Hard - shell backpack from NG - X67 .
 Damage : 5d6 + 3 or 3d4x10 M.D.
 Payload : 240 shots using a portable generator , which regenerates 8 shots per hour . Can also be directly linked to a vehicles power supply ( Nuclear or Solid - Ox ) giving it a virtually unlimited payload .
 Weight : Laser cannon - 40 lbs . , Portable generator - 30 lbs .
 Last edited by Victor Singer on Mon Oct 22 , 2018 3:40 pm , edited 47 times in total .
 Victor Calvin Singer was born to Robert and Karen Singer , he also has a sister named Christine who is just a year younger . His family lives in the Manistique Imperium where Victor was raised . His father works in a Northern Gun assembly plant that just so happens to turn out final assemblies of robot vehicles and power armor suits , interestingly enough his sister also works at the plant these days , though she began there after Victor left for the Army . From an early age he was fascinated by the robot vehicles and power armor that has dad built . Mainly it was the smaller power armor suits that caught his attention , how a soldier could go into combat in such a suit and take out a much larger , more heavily armored robot or a 20 ’ tall supernatural monster was exciting to him . So , when he turned 18 it seemed only natural that he join the Army and apply to be a PA pilot . With his reflexes plus his almost obsessive knowledge of power armor , he became an excellent soldier … at least on paper and tests .
 Somehow , during his 4 years of service , Victor was always assigned or re - assigned to a unit that was in the single most boring and inactive post . He has been in only 4 minor fire fights and even than his squad was either on mop - up duty or just on standby in case things went sideways . So , once his 4 years of enlistment was up , Victor applied for private military contractor status , purchased a Blue Boy power suit and moved on . He has done half a dozen solo jobs , but he ’s found it is much more difficult to carry out a mission when you do n’t have a squad at your back . This lead him to contact some old friends back home about any work they might know of . One friend in particular responded , Mindy Corsair . She in turn suggested he get hold of Emerald Ecks and after a long conversation about her brother Royal and his ... life lessons ... Emerald convinced Victor to reach out to Royal . Apparently her brother had for some time now been running a mercenary unit out of MercTown and she thought they might be hiring . Victor has misgivings about Royal , as he was n't the nicest guy when they were kids , but Victor knows and trusts both Emerald and Mindy . In particular Mindy 's word means most to him since she was not a fan of Royal when they were younger ... now she seems to be genuinely proud of the guy . Victor figures it could n't hurt to go and meet up with Royal and see what is what . So , he contacted Royal and the two set up a meet in MercTown . Now , looking at the city of MercTown from a nearby hilltop , Victor hopes his trek here means work ... preferably paying work .
 Last edited by Victor Singer on Sat Jun 04 , 2016 10:36 am , edited 6 times in total .
 Used T-42 Commando = 38,000 ( pg . 38 of Triax & NGR ) Note : Has only 45 MDC , -5 % Prowl ( only to prowl , other movement is fine ) . What Victor did n't notice is that the legs have some bad repair to the fabric lining , it crinkles and cracks as the wearer moves . What he did notice is that the suit has been outfitted with four concealed pockets . One on the back is useful for a medium or smaller handgun . Two are on the inside of thighs are are suitable for hiding papers or the like ( such as maps ) . The third is on the inside of the chest , it 's only accessible when the suit is off . It can hold a larger volume of flat stuff compared to the thighs .
 Used NG - WJ10 Speedpack ( electric ) = 28,000 ( pg . 193 of Northern Gun 2 ) Note : Has only 28 MDC , gets only 750 miles per charge , 12 years old . Otherwise in great working order . It would take rebuilding the housing almost completely to get the MDC back . Installing a new battery would restore the range to 800 miles .
 Victor will look over several junkyards for this and will ask each of the owners to keep an eye out for the launcher or see if any of them will place an order for one , so to speak .
 None are available . Most of the dealers in Merctown are unfamiliar with the NGR military hardware . The Super Trooper is rare outside the military even in Europe . By the third junkyard the dealer tells Victor he got a call from Kraus telling him to not deal with Victor .
 1d8 = 4 : Receive a +2D6 Attribute Boost to P.S.
 ( 1 ) Receive a +2D4 Attribute Boost to M.E.
 +2d4 = 4 to M.E.
 +1d4 = 3x10=30 to P.P.E.
 NOTE : No point in rolling the sub table on the next two , since both are on the same sub - table and Victor already has 2 of the 4 on said sub - table .
 ( 1 ) Receive a +2D4 Attribute Boost to P.P.


text:
HomeLight runs the stats on each of the 134 agents in Redding so that you can select the top performing real estate agents. The top 3% Redding agents work with 487 homes and get them sold in 53 days.
Redding, CA has 134 active real estate agents. The average real estate agent in Redding sells about 365 homes and each home spends about 80 days on Redding's housing market. Let's see how the top 3% perform in comparison.
In contrast with the average Redding real estate agent, the top seller's agents sell 310.17 more homes, close deals 26.39 days faster, and earn sellers an extra 9.1% on each home sale.
When compared against the average real estate agent, the top Redding buyer's agents move about 277 properties and save buyers $24,823 on their home purchases.
When is the right time to hire a real estate agent in Redding?
It's going to depend on the temperature of the Redding housing market but we generally recommend that you hire a real estate agent as soon as you're thinking of selling your home. Generally speaking, that's anywhere from 3 to 6 months prior to your desired move date.
How important is it to hire a top real estate agent in Redding?
On average, the top performing 5% of seller's agents generally command a higher selling price (+9%) than the average real estate agent. The top performing 5% of buyer's agents generally save their clients 2.5% more than the average real estate agent at closing. So, whether you're buying or selling your house, your odds of making more money on the transaction are higher if you work with a top performing agent. We encourage you to explore all of your options if you're selling a house in Redding, CA.
Why do I need to hire a licensed real estate agent in Redding?
What is the average real estate agent commission for agents in Redding?
While individual real estate agent commissions do vary, most real estate agents in Redding work for 6% of the home price.
How do I find a real estate agent that specializes in a specific Redding neighborhood?
What are the most important questions to ask when interviewing Redding neighborhood?
We've put together a list of 24 questions to ask your real estate agent. Make sure to ask them of your Redding real estate agent during interviews.
Why should I use HomeLight to find a Redding real estate agent?
HomeLight analyzes all real estate agents in Redding to bring you custom, unbiased, data-driven recommendations. We use actual home sales transaction data to compare Redding real estate agents and will only introduce you to the top performing agents.
Do these Redding real estate agents work for HomeLight?
What factors does HomeLight consider when evaluating real estate agents in Redding?

tokenized:
HomeLight runs the stats on each of the 134 agents in Redding so that you can select the top performing real estate agents . The top 3 % Redding agents work with 487 homes and get them sold in 53 days .
 Redding , CA has 134 active real estate agents . The average real estate agent in Redding sells about 365 homes and each home spends about 80 days on Redding 's housing market . Let 's see how the top 3 % perform in comparison .
 In contrast with the average Redding real estate agent , the top seller 's agents sell 310.17 more homes , close deals 26.39 days faster , and earn sellers an extra 9.1 % on each home sale .
 When compared against the average real estate agent , the top Redding buyer 's agents move about 277 properties and save buyers $ 24,823 on their home purchases .
 When is the right time to hire a real estate agent in Redding ?
 It 's going to depend on the temperature of the Redding housing market but we generally recommend that you hire a real estate agent as soon as you 're thinking of selling your home . Generally speaking , that 's anywhere from 3 to 6 months prior to your desired move date .
 How important is it to hire a top real estate agent in Redding ?
 On average , the top performing 5 % of seller 's agents generally command a higher selling price ( +9 % ) than the average real estate agent . The top performing 5 % of buyer 's agents generally save their clients 2.5 % more than the average real estate agent at closing . So , whether you 're buying or selling your house , your odds of making more money on the transaction are higher if you work with a top performing agent . We encourage you to explore all of your options if you 're selling a house in Redding , CA .
 Why do I need to hire a licensed real estate agent in Redding ?
 What is the average real estate agent commission for agents in Redding ?
 While individual real estate agent commissions do vary , most real estate agents in Redding work for 6 % of the home price .
 How do I find a real estate agent that specializes in a specific Redding neighborhood ?
 What are the most important questions to ask when interviewing Redding neighborhood ?
 We 've put together a list of 24 questions to ask your real estate agent . Make sure to ask them of your Redding real estate agent during interviews .
 Why should I use HomeLight to find a Redding real estate agent ?
 HomeLight analyzes all real estate agents in Redding to bring you custom , unbiased , data - driven recommendations . We use actual home sales transaction data to compare Redding real estate agents and will only introduce you to the top performing agents .
 Do these Redding real estate agents work for HomeLight ?
 What factors does HomeLight consider when evaluating real estate agents in Redding ?


text:
This is one of the many things in my life as a gay man that I cannot take for granted. Even if Bob and I were to marry in New York State, there is no guarantee that an emergency room in another state would honor our marriage, or respect the 23 years we’ve shared together, or the fact that my health effects Bob as much as it does me, or that his presence at my side could actually help me heal or keep me alive. I cannot presume that or any of the basic rights and needs that straight couples can take for granted. My legal right to property, bank accounts, employment, protection from hate-based violence, and more, are currently being voted on from state-to-state and argued by presidential candidates as if my civil rights and happiness are a mater of public opinion.
The thing is, when it comes to my rights as a gay man, I’ve never taken anything for granted. Growing up in the Midwest of the 1960s and ’70s, I never presumed I would have any real happiness at all. I never expected that I would be able to share my life with someone I really loved, no matter how much I longed for it. That was unimaginable back then.
And as I got older, I never expected that I would be blessed to meet the love of my life and be so loved by him. I never expected my parents to be as loving, accepting and respectful of me and Bob as they both were. Same from my sisters and brother. I never presumed I would be able to speak of my partner in the workplace or hold hands with him in the public park. All of these things that straight people can take for granted from the moment they start dating, are that much more of a gift for me, because I never expected them or felt entitled to them. These basic human needs, protected as rights for others, are still a gift to me, even though my own pursuit of happiness, life and liberty depend upon them.
And so, most importantly, I still can’t take this election for granted or my duty to vote for granted. I have friends–too smart for their own good–who are actually considering voting third party or not voting at all on principle, because of their differences or disappointment with both candidates on other issues. They take for granted that not voting will have no more affect on their own lives than voting would, but appear not to have considered the effect these elections could have on me and Bob.
And there are also extended family members and friends who intend to vote for former governor Romney. I can’t imagine voting for any candidate who I knew intended to limit any of their the civil rights, but they will vote for a candidate and his running mate who have promised to do so to Bob and me.
As in my youth in the 1960s and ’70s, I still can’t take for granted that anyone–family, friends, or fellow citizens of this land of the free–will have my health, my rights, my relationship, or my life in mind on Election Day. And I, once again, feel the same pain of second-class citizenship, lowered expectations, uncertainty, and vulnerability, that I’ve known my whole life.
Therefore, all I can ask of these friends and family, all I can hope, is that on Election Day, just before you pull the lever on the voting machine, or walk past the polling location in your neighborhood complacently, that you will imagine Bob and my faces. That you will remember your uncle, cousin, friend, whom you have cared about, bought Christmas gifts for, shared meals with, checked up on in emergencies and invited to your weddings, and think of how your vote can affect the quality of Bob and my life, the home that we share, and the rights that you are lucky enough to take for granted, that I will never take for granted, even if they are ever fully mine.

tokenized:
This is one of the many things in my life as a gay man that I can not take for granted . Even if Bob and I were to marry in New York State , there is no guarantee that an emergency room in another state would honor our marriage , or respect the 23 years we ’ve shared together , or the fact that my health effects Bob as much as it does me , or that his presence at my side could actually help me heal or keep me alive . I can not presume that or any of the basic rights and needs that straight couples can take for granted . My legal right to property , bank accounts , employment , protection from hate - based violence , and more , are currently being voted on from state - to - state and argued by presidential candidates as if my civil rights and happiness are a mater of public opinion .
 The thing is , when it comes to my rights as a gay man , I ’ve never taken anything for granted . Growing up in the Midwest of the 1960s and ’ 70s , I never presumed I would have any real happiness at all . I never expected that I would be able to share my life with someone I really loved , no matter how much I longed for it . That was unimaginable back then .
 And as I got older , I never expected that I would be blessed to meet the love of my life and be so loved by him . I never expected my parents to be as loving , accepting and respectful of me and Bob as they both were . Same from my sisters and brother . I never presumed I would be able to speak of my partner in the workplace or hold hands with him in the public park . All of these things that straight people can take for granted from the moment they start dating , are that much more of a gift for me , because I never expected them or felt entitled to them . These basic human needs , protected as rights for others , are still a gift to me , even though my own pursuit of happiness , life and liberty depend upon them .
 And so , most importantly , I still ca n’t take this election for granted or my duty to vote for granted . I have friends – too smart for their own good – who are actually considering voting third party or not voting at all on principle , because of their differences or disappointment with both candidates on other issues . They take for granted that not voting will have no more affect on their own lives than voting would , but appear not to have considered the effect these elections could have on me and Bob .
 And there are also extended family members and friends who intend to vote for former governor Romney . I ca n’t imagine voting for any candidate who I knew intended to limit any of their the civil rights , but they will vote for a candidate and his running mate who have promised to do so to Bob and me .
 As in my youth in the 1960s and ’ 70s , I still ca n’t take for granted that anyone – family , friends , or fellow citizens of this land of the free – will have my health , my rights , my relationship , or my life in mind on Election Day . And I , once again , feel the same pain of second - class citizenship , lowered expectations , uncertainty , and vulnerability , that I ’ve known my whole life .
 Therefore , all I can ask of these friends and family , all I can hope , is that on Election Day , just before you pull the lever on the voting machine , or walk past the polling location in your neighborhood complacently , that you will imagine Bob and my faces . That you will remember your uncle , cousin , friend , whom you have cared about , bought Christmas gifts for , shared meals with , checked up on in emergencies and invited to your weddings , and think of how your vote can affect the quality of Bob and my life , the home that we share , and the rights that you are lucky enough to take for granted , that I will never take for granted , even if they are ever fully mine .


text:
To know more about this amazing Institute Management System Please go through its presentation here.
Student Information Management System: Considering the time and distance limitations, AmpleTrails has come up with the new system called GTL Group (Guardian, Tutor an Learners’ group).
GTL Group is a web based solution to communicate daily campus information of a student to his/her guardian/parents. With the use of this system parents will be in touch with the tutor regarding every activity of their wards. Tutors also have the facility to communicate with parents whenever they want. Parents get notify for each and every achievement. Tutors have no need to write notices in students’ diary for any complaint or reminder.
See the presentation of Student Information Management System here.
Email us at info@ampletrails.com or call us at 9818390836 for pricing and installation of this machine. CBSE School List India. We have the best Institute Management System.
Download the free download and use it till you’re 100% satisfied with it.
Free trial version performs all the functions of the paid version.
Request for a demo and quote.
Institute Management System is also know as College Management System, school management System.

tokenized:
To know more about this amazing Institute Management System Please go through its presentation here .
 Student Information Management System : Considering the time and distance limitations , AmpleTrails has come up with the new system called GTL Group ( Guardian , Tutor an Learners ’ group ) .
 GTL Group is a web based solution to communicate daily campus information of a student to his / her guardian / parents . With the use of this system parents will be in touch with the tutor regarding every activity of their wards . Tutors also have the facility to communicate with parents whenever they want . Parents get notify for each and every achievement . Tutors have no need to write notices in students ’ diary for any complaint or reminder .
 See the presentation of Student Information Management System here .
 Email us at info@ampletrails.com or call us at 9818390836 for pricing and installation of this machine . CBSE School List India . We have the best Institute Management System .
 Download the free download and use it till you ’re 100 % satisfied with it .
 Free trial version performs all the functions of the paid version .
 Request for a demo and quote .
 Institute Management System is also know as College Management System , school management System .


text:
Make an appointment now to see this fantastic 2005 Toyota Hilux SR Auto 4×4 MY05 Dual Cab Green.
Are you looking for a Ute that can sort out your workdays and still be awesome on the weekend? Do we have the car for you!
Everybody’s favourite ute, the Toyota Hilux is up for sale and this one just looks the part, especially the alloy wheels which sets this ute apart from the rest.
Perfect car for the young couple, small family or tradie, call me and come and test drive today!
4 doors 5 seat Ute.
Click here to read full specifications of this 2005 Toyota Hilux SR Auto 4×4 MY05 Dual Cab Green.

tokenized:
Make an appointment now to see this fantastic 2005 Toyota Hilux SR Auto 4×4 MY05 Dual Cab Green .
 Are you looking for a Ute that can sort out your workdays and still be awesome on the weekend ? Do we have the car for you !
 Everybody ’s favourite ute , the Toyota Hilux is up for sale and this one just looks the part , especially the alloy wheels which sets this ute apart from the rest .
 Perfect car for the young couple , small family or tradie , call me and come and test drive today !
 4 doors 5 seat Ute .
 Click here to read full specifications of this 2005 Toyota Hilux SR Auto 4×4 MY05 Dual Cab Green .


text:
Whole House Ventilation – Why Do We Need to Ventilate?
This installation was installed for self-consumption only, with zero export to the grid, the customer (Toyota, Don Muang), will use the energy generated from the Solar PV system for their day time requirements. As the showroom is open seven days per week the system can run continuously. If the showroom was only open six days per week then it would need to be shut down on the day that it was closed, or it would overproduce and generate excess, wasted energy. At this time the MEA/PEA do not allow exporting excess energy to the grid.
The installation of the Solar panels was on the main Toyota showroom, spread over two roof tops, the roof type was metal sheet type. We (Kunini Electrical Services) used Chiko brand Solar mounting designed for metal sheet; using standard L-Feet (brackets) with specially designed aluminum rails, end clamps, mid clamps, earthing clips etc.
The system comprises 560 Jinko Solar Panels, the new Jinko Eagle Dual 72 Cell, 320Wp, Polycrystalline Panels (frameless) were used on this project, special care needed to be taken during the delivery and installation on the roof as these panels are frameless and flexible. Kunini’s Solar team installed the system to pre-designed layout calling for 35 strings, each string having 16 Solar Panels per string. Galvanized wire trays were used as containment for all cables, and flexible waterproof conduits were used from the wire trays to each string / array. The system has three Sungro SG60TL Inverters connected to an AC Combiner Box which houses the protection for the system.
The installation was carried out by our Solar team, the racking (solar mounting structure), and all the solar panels was installed in nine days, we were pretty impressed by the how quick our team was, our budgeted timeline for this segment was fifteen days. Installation of the wire tray, cables and general work on the roof was another seven days, bringing the total timeline for the installation to just over three weeks.
Seventy pairs of cables were run to the control room, along with a grounding system for the entire array. A total of 140 connectors were installed; MC4 connectors are special connectors to connect the solar panels to the string cables which then connect to the Solar Inverters. Inside the control room we installed an AC Sub Distribution Panel which supplies AC power to the three inverters. In addition, we installed an individual MCCB between the MDB (main distribution board), and the Solar Sub DB allowing for safe isolation of the system for servicing. The system also has a weather station installed so that parameters such as Solar Irradiance, peak sun hours, total sun hours per day / month can all be monitored.
The system is up and functioning as agreed, the performance is good, and everything is on track for a favorable ROI.

tokenized:
Whole House Ventilation – Why Do We Need to Ventilate ?
 This installation was installed for self - consumption only , with zero export to the grid , the customer ( Toyota , Don Muang ) , will use the energy generated from the Solar PV system for their day time requirements . As the showroom is open seven days per week the system can run continuously . If the showroom was only open six days per week then it would need to be shut down on the day that it was closed , or it would overproduce and generate excess , wasted energy . At this time the MEA / PEA do not allow exporting excess energy to the grid .
 The installation of the Solar panels was on the main Toyota showroom , spread over two roof tops , the roof type was metal sheet type . We ( Kunini Electrical Services ) used Chiko brand Solar mounting designed for metal sheet ; using standard L - Feet ( brackets ) with specially designed aluminum rails , end clamps , mid clamps , earthing clips etc .
 The system comprises 560 Jinko Solar Panels , the new Jinko Eagle Dual 72 Cell , 320Wp , Polycrystalline Panels ( frameless ) were used on this project , special care needed to be taken during the delivery and installation on the roof as these panels are frameless and flexible . Kunini ’s Solar team installed the system to pre - designed layout calling for 35 strings , each string having 16 Solar Panels per string . Galvanized wire trays were used as containment for all cables , and flexible waterproof conduits were used from the wire trays to each string / array . The system has three Sungro SG60TL Inverters connected to an AC Combiner Box which houses the protection for the system .
 The installation was carried out by our Solar team , the racking ( solar mounting structure ) , and all the solar panels was installed in nine days , we were pretty impressed by the how quick our team was , our budgeted timeline for this segment was fifteen days . Installation of the wire tray , cables and general work on the roof was another seven days , bringing the total timeline for the installation to just over three weeks .
 Seventy pairs of cables were run to the control room , along with a grounding system for the entire array . A total of 140 connectors were installed ; MC4 connectors are special connectors to connect the solar panels to the string cables which then connect to the Solar Inverters . Inside the control room we installed an AC Sub Distribution Panel which supplies AC power to the three inverters . In addition , we installed an individual MCCB between the MDB ( main distribution board ) , and the Solar Sub DB allowing for safe isolation of the system for servicing . The system also has a weather station installed so that parameters such as Solar Irradiance , peak sun hours , total sun hours per day / month can all be monitored .
 The system is up and functioning as agreed , the performance is good , and everything is on track for a favorable ROI .


text:
ALEXANDRIA, VA – In an effort to educate and help consumers, the American Moving and Storage Association (AMSA) asked the Department of Transportation to impose requirements on household goods transportation brokers that use the Internet to market interstate moving services.
40 Florida-based scam movers, AMSA President Joe Harrison wrote to Transportation Secretary Norman Y. Mineta, urging him to strike another blow at one of the roots of the problem-questionable practices of many Internet brokers of household goods transportation services.
Under the rules proposed by AMSA, all Internet HHG brokers would have to abide by the same federal regulations that apply to all other freight transportation brokers, as well as others devised to meet the unique challenges posed by the explosive growth of broker websites on the Internet medium.
The regulations proposed by AMSA are designed to fill the existing regulatory gap. The current regulations are passive while the proposed regulations would require brokers to act affirmatively by making specified disclosures to consumers. Importantly, AMSA emphasized, the regulations would apply regardless of the medium through which services are held out and therefore ensure that the Internet is not used as a device to avoid regulation.
The broker would be required to disclose its federal license, the capacity in which it holds itself out, and reveal its locations and a telephone number so that customers can communicate with a person. This is designed to remove the cloak of anonymity.
Brokers could only refer shipments to federally licensed interstate movers.
Brokers would provide information concerning the consumer’s rights and responsibilities, explain carrier liability options for loss or damage, and the availability of a dispute settlement program.
Because the vast majority of scam mover abuses involve deceptive cost estimates, brokers would have to provide a full written explanation of all charges and how they might change in the course of a move.
A common practice of scam brokers is to demand a deposit in advance of the move, a practice that is not followed by legitimate movers. Under the AMSA proposal, the terms governing deposits and forfeitures would be fully disclosed before a deposit could be demanded.
Because it is common for scam brokers to close down and disappear, brokers would be required to maintain a bond or trust agreement and to disclose to consumers that this is a potential avenue for recourse.
Brokers would be responsible for reporting mover abuses and violations of the consumer protection regulations that are brought to their attention by their customers to the Federal Motor Carrier Safety Administration.
Because of the scope of the problem, the association asked Mineta to act as quickly as possible. “AMSA, Congress, and consumer groups all agree that consumer education is an important component of the overall effort to steer consumers away from utilizing rogue movers and brokers,” Harrison told the DOT secretary.

tokenized:
ALEXANDRIA , VA – In an effort to educate and help consumers , the American Moving and Storage Association ( AMSA ) asked the Department of Transportation to impose requirements on household goods transportation brokers that use the Internet to market interstate moving services .
 40 Florida - based scam movers , AMSA President Joe Harrison wrote to Transportation Secretary Norman Y. Mineta , urging him to strike another blow at one of the roots of the problem - questionable practices of many Internet brokers of household goods transportation services .
 Under the rules proposed by AMSA , all Internet HHG brokers would have to abide by the same federal regulations that apply to all other freight transportation brokers , as well as others devised to meet the unique challenges posed by the explosive growth of broker websites on the Internet medium .
 The regulations proposed by AMSA are designed to fill the existing regulatory gap . The current regulations are passive while the proposed regulations would require brokers to act affirmatively by making specified disclosures to consumers . Importantly , AMSA emphasized , the regulations would apply regardless of the medium through which services are held out and therefore ensure that the Internet is not used as a device to avoid regulation .
 The broker would be required to disclose its federal license , the capacity in which it holds itself out , and reveal its locations and a telephone number so that customers can communicate with a person . This is designed to remove the cloak of anonymity .
 Brokers could only refer shipments to federally licensed interstate movers .
 Brokers would provide information concerning the consumer ’s rights and responsibilities , explain carrier liability options for loss or damage , and the availability of a dispute settlement program .
 Because the vast majority of scam mover abuses involve deceptive cost estimates , brokers would have to provide a full written explanation of all charges and how they might change in the course of a move .
 A common practice of scam brokers is to demand a deposit in advance of the move , a practice that is not followed by legitimate movers . Under the AMSA proposal , the terms governing deposits and forfeitures would be fully disclosed before a deposit could be demanded .
 Because it is common for scam brokers to close down and disappear , brokers would be required to maintain a bond or trust agreement and to disclose to consumers that this is a potential avenue for recourse .
 Brokers would be responsible for reporting mover abuses and violations of the consumer protection regulations that are brought to their attention by their customers to the Federal Motor Carrier Safety Administration .
 Because of the scope of the problem , the association asked Mineta to act as quickly as possible . “ AMSA , Congress , and consumer groups all agree that consumer education is an important component of the overall effort to steer consumers away from utilizing rogue movers and brokers , ” Harrison told the DOT secretary .


text:
The orientation of nanoscale mineral platelets was quantitatively evaluated in relation to the shape of lacunae associated with partially embedded osteocytes (osteoblastic–osteocytes) on the surface of deproteinised trabecular bone of adult sheep. By scanning electron microscopy and image analysis, the mean orientation of mineral platelets at the osteoblastic–osteocyte lacuna (Ot.Lc) floor was found to be 19° ± 14° in the tibia and 20° ± 14° in the femur. Further, the mineral platelets showed a high degree of directional coherency: 37 ± 7 % in the tibia and 38 ± 9 % in the femur. The majority of Ot.Lc in the tibia (69.37 %) and the femur (74.77 %) exhibited a mean orientation of mineral platelets between 0° and 25°, with the largest fraction within a 15°–20° range, 17.12 and 19.8 % in the tibia and femur, respectively. Energy dispersive X-ray spectroscopy and Raman spectroscopy were used to characterise the features observed on the anorganic bone surface. The Ca/P (atomic %) ratio was 1.69 ± 0.1 within the Ot.Lc and 1.68 ± 0.1 externally. Raman spectra of NaOCl-treated bone showed peaks associated with carbonated apatite: ν1, ν2 and ν4 PO4 3−, and ν1 CO3 2−, while the collagen amide bands were greatly reduced in intensity compared to untreated bone. The apatite-to-collagen ratio increased considerably after deproteinisation; however, the mineral crystallinity and the carbonate-to-phosphate ratios were unaffected. The ~19°–20° orientation of mineral platelets in at the Ot.Lc floor may be attributable to a gradual rotation of osteoblasts in successive layers relative to the underlying surface, giving rise to the twisted plywood-like pattern of lamellar bone.
The online version of this article (doi: 10.1007/s00223-015-0072-8) contains supplementary material, which is available to authorised users.
This study was supported by the Swedish Research Council (Grant K2015-52X-09495-28-4), the BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, the Region Västra Götaland, an ALF/LUA Grant, the IngaBritt and Arne Lundberg Foundation, the Dr. Felix Neubergh Foundation, Promobilia, the Hjalmar Svensson Foundation, and the Materials Science Area of Advance at Chalmers and the Department of Biomaterials, University of Gothenburg.
Furqan A. Shah, Ezio Zanghellini, Aleksandar Matic, Peter Thomsen, and Anders Palmquist declare that they have no conflict of interest.

tokenized:
The orientation of nanoscale mineral platelets was quantitatively evaluated in relation to the shape of lacunae associated with partially embedded osteocytes ( osteoblastic – osteocytes ) on the surface of deproteinised trabecular bone of adult sheep . By scanning electron microscopy and image analysis , the mean orientation of mineral platelets at the osteoblastic – osteocyte lacuna ( Ot . Lc ) floor was found to be 19 ° ± 14 ° in the tibia and 20 ° ± 14 ° in the femur . Further , the mineral platelets showed a high degree of directional coherency : 37 ± 7 % in the tibia and 38 ± 9 % in the femur . The majority of Ot . Lc in the tibia ( 69.37 % ) and the femur ( 74.77 % ) exhibited a mean orientation of mineral platelets between 0 ° and 25 ° , with the largest fraction within a 15 ° –20 ° range , 17.12 and 19.8 % in the tibia and femur , respectively . Energy dispersive X - ray spectroscopy and Raman spectroscopy were used to characterise the features observed on the anorganic bone surface . The Ca / P ( atomic % ) ratio was 1.69 ± 0.1 within the Ot . Lc and 1.68 ± 0.1 externally . Raman spectra of NaOCl - treated bone showed peaks associated with carbonated apatite : ν1 , ν2 and ν4 PO4 3− , and ν1 CO3 2− , while the collagen amide bands were greatly reduced in intensity compared to untreated bone . The apatite - to - collagen ratio increased considerably after deproteinisation ; however , the mineral crystallinity and the carbonate - to - phosphate ratios were unaffected . The ~19 ° –20 ° orientation of mineral platelets in at the Ot . Lc floor may be attributable to a gradual rotation of osteoblasts in successive layers relative to the underlying surface , giving rise to the twisted plywood - like pattern of lamellar bone .
 The online version of this article ( doi : 10.1007 / s00223 - 015 - 0072 - 8) contains supplementary material , which is available to authorised users .
 This study was supported by the Swedish Research Council ( Grant K2015 - 52X-09495 - 28 - 4 ) , the BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy , the Region Västra Götaland , an ALF / LUA Grant , the IngaBritt and Arne Lundberg Foundation , the Dr. Felix Neubergh Foundation , Promobilia , the Hjalmar Svensson Foundation , and the Materials Science Area of Advance at Chalmers and the Department of Biomaterials , University of Gothenburg .
 Furqan A. Shah , Ezio Zanghellini , Aleksandar Matic , Peter Thomsen , and Anders Palmquist declare that they have no conflict of interest .


text:
Royal Park Nature Play Playground is located in Melbourne. By using our Melbourne online travel route planner , you can arrange your visit to Royal Park Nature Play Playground and other attractions in Melbourne.
Best park I have been to in Melbourne. Several huge park areas. A water area with sprinkler type set up that my daughter loved. Only issue which is mentioned a few times is lack of shade. Make sure to bring sunscreen and hats. Also change of clothes after the water area. So much variety and nice bbq areas available.
Great place to spend a few hours. The out in nature feel, right on the fringe of the city. Heaps for the kids to do. Sand pits, water setups, bridges, slides and swings. Hills to climb and bushy tree areas to make natures cubby houses. Public toilets on site. Nowhere to eat that I could see. Bring some spare clothes or bathers even as they will get dirty. Great spot.

tokenized:
Royal Park Nature Play Playground is located in Melbourne . By using our Melbourne online travel route planner , you can arrange your visit to Royal Park Nature Play Playground and other attractions in Melbourne .
 Best park I have been to in Melbourne . Several huge park areas . A water area with sprinkler type set up that my daughter loved . Only issue which is mentioned a few times is lack of shade . Make sure to bring sunscreen and hats . Also change of clothes after the water area . So much variety and nice bbq areas available .
 Great place to spend a few hours . The out in nature feel , right on the fringe of the city . Heaps for the kids to do . Sand pits , water setups , bridges , slides and swings . Hills to climb and bushy tree areas to make natures cubby houses . Public toilets on site . Nowhere to eat that I could see . Bring some spare clothes or bathers even as they will get dirty . Great spot .