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MECHANICSBURG, PENNSYLVANIA (July 24, 2015) – The World of Outlaw (WoO) Sprint Car Series competitors invaded the famed 1/2 mile at Williams Grove Speedway on Friday night for the first of two nights of racing in the Summer Nationals. There were 39 cars present in the front and backstretch pit areas and every single one of them had three goals: (1) get a good time trial time lap in; (2) get the car in the show through qualifying action; and, (3) end the night in victory lane. All challenging tasks for the drivers of these speed machines at his unique racing oval.
Jason climbed aboard the Dissolvalloy Frac Ball Revolution/Jonestown KOA #41 Maxim in Qualifying Flight B for his time trial laps. He accelerated down the back straightaway and came around turn four to take the green flag. He ran two very consistent laps, but the quicker of the two came in at 17.339 seconds, which was 12th quick in his group.
Starting from the outside of row three beside Williams Grove regular, Brian Montieth, he paced around in the Waco Metal/Priority Aviation Services, LLC entry readying himself for eight laps of high speed entertainment. When the yellow lights changed to green around the track, Daryn Pittman seized the top spot from the pole position as everyone was dicing for their space behind him. Jason was racing hard with Montieth for the fifth and final qualifying position, but came up just short with a sixth place finish when the checkered flag waved over the field.
Relegated to the second Last Chance Showdown, he rolled his Hoosier Racing Tires and Weld Racing wheels out on to the racing surface. There were only two transfer positions up for grabs and he was poised to start from the third starting spot in the 12 lap event. When the racing got up to speed, Shane Stewart and Brent Marks took the top two spaces on the scoreboard with Jason battling David Gravel and Cory Haas for the third position. The racing was tight and Gravel and Haas got together coming out of two which slowed Jason. The yellow did not come out, so Stewart and Marks puts some distance between themselves and the Ragin’ Cajun who was now solidly in the third position. The Eunice, Louisiana native focused and set his sights on chasing down Marks. Each lap the distance between the two narrowed, but Jason ran out of laps and missed the last transfer spot by six car lengths.
Electing to use a WoO provisional, Jason started from the twenty fifth starting position in a loaded field. Donny Schatz and Joey Saldana led the field from the front row with Saldana leading the first eight laps. Meanwhile, Jason was hard at work making his way forward from further back in the pack aboard the Waco Metal/ISC Racers Tape machine. He had made his way up to the 17th position when a red flag waved for Greg Hodnett who flipped on the exit of turn two after contact with Paul McMahan. When racing resumed, he continued his workmanlike effort and advanced up as high as 14th in the running order. Schatz took the lead on lap 9 and led through the middle stages of the race, but on lap 18 Danny Dietrich tracked him down on the low side of the track and made the pass for the lead coming out of turn four. Dietrich would go on to take the victory ahead of Schatz, Sammy Swindell, McMahan and Saldana with Jason battling hard to come home with a 16th place finish on night one of the Summer Nationals.

tokenized:
MECHANICSBURG , PENNSYLVANIA ( July 24 , 2015 ) – The World of Outlaw ( WoO ) Sprint Car Series competitors invaded the famed 1/2 mile at Williams Grove Speedway on Friday night for the first of two nights of racing in the Summer Nationals . There were 39 cars present in the front and backstretch pit areas and every single one of them had three goals : ( 1 ) get a good time trial time lap in ; ( 2 ) get the car in the show through qualifying action ; and , ( 3 ) end the night in victory lane . All challenging tasks for the drivers of these speed machines at his unique racing oval .
 Jason climbed aboard the Dissolvalloy Frac Ball Revolution / Jonestown KOA # 41 Maxim in Qualifying Flight B for his time trial laps . He accelerated down the back straightaway and came around turn four to take the green flag . He ran two very consistent laps , but the quicker of the two came in at 17.339 seconds , which was 12th quick in his group .
 Starting from the outside of row three beside Williams Grove regular , Brian Montieth , he paced around in the Waco Metal / Priority Aviation Services , LLC entry readying himself for eight laps of high speed entertainment . When the yellow lights changed to green around the track , Daryn Pittman seized the top spot from the pole position as everyone was dicing for their space behind him . Jason was racing hard with Montieth for the fifth and final qualifying position , but came up just short with a sixth place finish when the checkered flag waved over the field .
 Relegated to the second Last Chance Showdown , he rolled his Hoosier Racing Tires and Weld Racing wheels out on to the racing surface . There were only two transfer positions up for grabs and he was poised to start from the third starting spot in the 12 lap event . When the racing got up to speed , Shane Stewart and Brent Marks took the top two spaces on the scoreboard with Jason battling David Gravel and Cory Haas for the third position . The racing was tight and Gravel and Haas got together coming out of two which slowed Jason . The yellow did not come out , so Stewart and Marks puts some distance between themselves and the Ragin ’ Cajun who was now solidly in the third position . The Eunice , Louisiana native focused and set his sights on chasing down Marks . Each lap the distance between the two narrowed , but Jason ran out of laps and missed the last transfer spot by six car lengths .
 Electing to use a WoO provisional , Jason started from the twenty fifth starting position in a loaded field . Donny Schatz and Joey Saldana led the field from the front row with Saldana leading the first eight laps . Meanwhile , Jason was hard at work making his way forward from further back in the pack aboard the Waco Metal / ISC Racers Tape machine . He had made his way up to the 17th position when a red flag waved for Greg Hodnett who flipped on the exit of turn two after contact with Paul McMahan . When racing resumed , he continued his workmanlike effort and advanced up as high as 14th in the running order . Schatz took the lead on lap 9 and led through the middle stages of the race , but on lap 18 Danny Dietrich tracked him down on the low side of the track and made the pass for the lead coming out of turn four . Dietrich would go on to take the victory ahead of Schatz , Sammy Swindell , McMahan and Saldana with Jason battling hard to come home with a 16th place finish on night one of the Summer Nationals .


text:
George set out on a very windy day to see his friend Sam who was sick in bed. Hours later, he pulled his weary body into Sam’s house.
”Then how ever did you make it over here?” Sam asked.
This entry was posted in Family Jokes, Miscellaneous Jokes, People Jokes and tagged friend, windy. Bookmark the permalink.

tokenized:
George set out on a very windy day to see his friend Sam who was sick in bed . Hours later , he pulled his weary body into Sam ’s house .
 ” Then how ever did you make it over here ? ” Sam asked .
 This entry was posted in Family Jokes , Miscellaneous Jokes , People Jokes and tagged friend , windy . Bookmark the permalink .


text:
The thermostat, which controls the temperature in the house, broke last night. -contains an explanation.
Which statement about fairy tales suggests an indirect cause? A. Jack killed the giant because he sold the cow for magic beans. B. Sleeping Beauty was warned to stay away from needles but did not listen. C. Hansel and Gretel went out into the woods and ended up getting lost. D. Cinderella lost her glass slipper on the stairs precisely at midnight.

tokenized:
The thermostat , which controls the temperature in the house , broke last night . -contains an explanation .
 Which statement about fairy tales suggests an indirect cause ? A. Jack killed the giant because he sold the cow for magic beans . B. Sleeping Beauty was warned to stay away from needles but did not listen . C. Hansel and Gretel went out into the woods and ended up getting lost . D. Cinderella lost her glass slipper on the stairs precisely at midnight .


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Amid the rural idyll of Spain’s central provinces, Toledo, Cáceres, Salamanca and Segovia host some of Europe’s finest cultural treasures. Roman aqueducts sweep over Gothic cathedrals, cobblestone streets weave between sun-dappled plazas and medieval watchtowers stand guard over Baroque mansions. It’s all knitted together with stays in historic hotels and scenic country drives, affording you the flexibility to explore at your own pace. Stop off everywhere from postcard-perfect villages to hilltop citadels.
Beginning with complimentary airport lounge access, you’ll fly out to Madrid, picking up your hire car and perhaps stopping to explore the Spanish capital’s grand delights. You’ll then make the short, country drive south to Toledo. Here, within perfectly preserved city walls, Roman aqueducts vie for attention alongside ancient Islamic monuments, 12th-century synagogues and a Gothic cathedral considered to be among Europe’s greatest. See it all as you wander the city’s labyrinthine laneways, pausing to sample the food and wine that led Toledo to be named as Spain’s Capital of Gastronomy in 2016.
Heading west, we highly recommend stopping at Gaudalupe – a hilltop village famed for its Royal Monastery of Santa Maria. Dating back to the late 13th century, it’s a lesson in Spanish ecclesiastical architecture with brick turrets hiding sculptured treasures. You’ll then continue on to Cáceres where you’ll stay in a converted Renaissance palace in the heart of the UNESCO-listed old town. Here, wandering down cobblestone streets, you’ll take in a unique blend of Roman, Islamic and Gothic architecture that plays out over everything from medieval towers to fortified mansions.
En route to Salamanca, call in at Plasencia, a great walled city whose imposing fortifications hide Las Catedrales – a magnificent complex of stately stone palaces, Romanesque churches and lively tapas bars. Then, in Salamanca itself, you’ll stay right among its golden sandstone centre, enjoying privileged views of the city’s burnished cathedral. It’s an iconic aesthetic that plays out across pretty plazas, 13th-century universities and a veritable catalogue of monuments, ranging from daringly Baroque to sternly Gothic. There’s even a 15th-century house dressed in no fewer than 350 seashells.
Your holiday concludes with visits to two more UNESCO-listed treasures. The first, Ávila, was the birthplace of Mother Teresa, its lofty hilltop perch dressed in 11th-century fortifications, spanning from sky-scraping turrets to great monumental gates. You’ll then end in Segovia, whose ancient Roman aqueduct stands over royal residences, 16th-century Gothic cathedrals and the Alcázar. A fairytale palace of conical turrets and buttressed walls, it’s not hard to see why it’s said to have been the inspiration for Walt Disney’s Cinderella castle.
Driving back to Madrid, drop your hire car off at the airport for your flight home.

tokenized:
Amid the rural idyll of Spain ’s central provinces , Toledo , Cáceres , Salamanca and Segovia host some of Europe ’s finest cultural treasures . Roman aqueducts sweep over Gothic cathedrals , cobblestone streets weave between sun - dappled plazas and medieval watchtowers stand guard over Baroque mansions . It ’s all knitted together with stays in historic hotels and scenic country drives , affording you the flexibility to explore at your own pace . Stop off everywhere from postcard - perfect villages to hilltop citadels .
 Beginning with complimentary airport lounge access , you ’ll fly out to Madrid , picking up your hire car and perhaps stopping to explore the Spanish capital ’s grand delights . You ’ll then make the short , country drive south to Toledo . Here , within perfectly preserved city walls , Roman aqueducts vie for attention alongside ancient Islamic monuments , 12th - century synagogues and a Gothic cathedral considered to be among Europe ’s greatest . See it all as you wander the city ’s labyrinthine laneways , pausing to sample the food and wine that led Toledo to be named as Spain ’s Capital of Gastronomy in 2016 .
 Heading west , we highly recommend stopping at Gaudalupe – a hilltop village famed for its Royal Monastery of Santa Maria . Dating back to the late 13th century , it ’s a lesson in Spanish ecclesiastical architecture with brick turrets hiding sculptured treasures . You ’ll then continue on to Cáceres where you ’ll stay in a converted Renaissance palace in the heart of the UNESCO - listed old town . Here , wandering down cobblestone streets , you ’ll take in a unique blend of Roman , Islamic and Gothic architecture that plays out over everything from medieval towers to fortified mansions .
 En route to Salamanca , call in at Plasencia , a great walled city whose imposing fortifications hide Las Catedrales – a magnificent complex of stately stone palaces , Romanesque churches and lively tapas bars . Then , in Salamanca itself , you ’ll stay right among its golden sandstone centre , enjoying privileged views of the city ’s burnished cathedral . It ’s an iconic aesthetic that plays out across pretty plazas , 13th - century universities and a veritable catalogue of monuments , ranging from daringly Baroque to sternly Gothic . There ’s even a 15th - century house dressed in no fewer than 350 seashells .
 Your holiday concludes with visits to two more UNESCO - listed treasures . The first , Ávila , was the birthplace of Mother Teresa , its lofty hilltop perch dressed in 11th - century fortifications , spanning from sky - scraping turrets to great monumental gates . You ’ll then end in Segovia , whose ancient Roman aqueduct stands over royal residences , 16th - century Gothic cathedrals and the Alcázar . A fairytale palace of conical turrets and buttressed walls , it ’s not hard to see why it ’s said to have been the inspiration for Walt Disney ’s Cinderella castle .
 Driving back to Madrid , drop your hire car off at the airport for your flight home .


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THE DIRECTOR ROBERT Rodriguez is celebrated for completing his Film Making rather rapidly. He has portrayed his procedure as one difficult day of work, starting with shots and moving into altering all around the same time. He gets a kick out of the chance to have the capacity to survey his work as it’s delivered with the goal that he realizes what the last item may resemble. Contrast that with somebody like George Lucas, who invests a considerable amount of energy and spending plan in after creation, and it’s anything but difficult to see that innovation has taken film in altogether different ways.
Innovation’s most prominent effect is maybe felt in new cameras that enable cinematographers to shoot in a better quality, giving watchers a chance to take in a greater amount of the stunning work in set plan. Innovation likewise drives whole portions of film now, empowering motion pictures that were impractical some time recently. Here are a few illustrations where innovation has driven film making.
Film is the favored medium of old fashioned film producers, however it’s typically too exorbitant for a studio to approve. Film conveys a few hindrances, that smaller person the realness that the film producer is going for. Beside the cost, film is difficult to reuse. That implies a day of shooting must have film the team can utilize, or else each asset devoured that day was a waste. The expenses of film don’t end the day of shooting either. Cinematographers who utilize film must create it, and after that there is the expensive procedure of altering the film.
Going computerized generally implies prior the vast canisters of film that used to be synonymous with film making. It likewise implies creation organizations finish their shoot plans with less waste, holding the whole task under or near spending plan.
After generation is another region where advanced trumps the use of film. Adding visual impacts to film was frequently an exact workmanship, where the impact needed to mix consistently with what was being shot. This was a careful procedure that editors never again experience. Computerized impacts are made and added to the shot inside a similar program or group of projects. This product likewise enables editors to chip away at whole segments of a film, effortlessly sorting scenes out after the after generation impacts are included. That incorporates sound, which now has a top notch advanced record that guarantees the gathering of people will hear each word and activity that they see.
The final product is a bit of film that looks cleaner, with impacts that mix flawlessly with the motion picture. The group of onlookers more often than not can’t tell when CGI has been utilized, however it’s an effective device film creators have progressively used to set climate.
Shooting in computerized is considerably simpler on the grounds that you can accomplish more in less time. Different cameras can keep running on a similar shot, so you generally get the point you need without wasting time on retakes. I like shooting carefully on the grounds that it makes it simple. To shoot different takes, and to get various edges all the more monetarily. An executive’s bread and margarine is pace and execution. I cherish having the capacity to shoot everything. Indeed, with the performing artists’ authorization, the practices. You never recognize what pieces you’ll have the capacity to utilize later in altering.
Combined with the new unfaltering cam hardware that film has favored, the final product is a more cozy shot. The gathering of people feels display at the time on the grounds that the focal point we are permitted to look through feels valid. Film creators likewise invest less energy re-shooting a similar scene to get the correct point.
The way toward conveying film in computerized has not exactly hit the pinnacle of what it is prepared to do, however the non mainstream film creator particularly stands to pick up. Conveyance through YouTube has been the most well-known type of promoting for a long while. Studios have discharged huge spending trailers, while independent film. Creators have looked for subsidizing and intrigued eyes posting content through different YouTube channels. Obviously, the antagonistic influence is that quality has fundamentally declined, however that is increasingly an element of volume. YouTube clients additionally swarm source what is well known with a thumbs up. The helping other people to discover new and intriguing substance without investing excessively energy burrowing for it.
Rights to films are now circulated to purchasers carefully, yet this market has not been completely tapped. There is much civil argument with regards to the fate of film utilization. However organizations appear to circulate films on the web. The 2011 film Tower Heist with Ben Stiller was nearly discharged to Comcast clients nearby the dramatic discharge. However the thought was rejected after a few venues debilitated not to demonstrate the film in dissent. Albeit computerized guarantees an energizing new universe of dissemination. The matter of film presently can’t seem to get up to speed with this thought.
The conservation of film isn’t something we consider as shoppers, yet it’s the very reason despite everything. Film will disintegrate and harm after some time, and it’s to a great degree combustible as well. There are basically an excessive number of techniques for film to outlast its helpfulness. Advanced films can be put away on organization servers, without taking up excessively space. The expenses to keep up this foundation are additionally lower than the expenses to store and re-ace film.
Advanced documents are likewise simple to reinforcement and reestablish. Pixar had a now well known occurrence while making Toy Story 2, where one of the artists lost nearly the whole film taking a shot at it at home because of an awful reinforcement. Beside this little indiscretion, the reinforcement framework has permitted creation. Organizations access to prior forms of a film, and also a source to store shots utilized for dailies.
Without innovation, it would be almost unthinkable for Hollywood to create the volume of films that it does. Film may be a pleasant idea for that vintage feel, yet the items of common sense of advanced have to a great extent put the film.

tokenized:
THE DIRECTOR ROBERT Rodriguez is celebrated for completing his Film Making rather rapidly . He has portrayed his procedure as one difficult day of work , starting with shots and moving into altering all around the same time . He gets a kick out of the chance to have the capacity to survey his work as it ’s delivered with the goal that he realizes what the last item may resemble . Contrast that with somebody like George Lucas , who invests a considerable amount of energy and spending plan in after creation , and it ’s anything but difficult to see that innovation has taken film in altogether different ways .
 Innovation ’s most prominent effect is maybe felt in new cameras that enable cinematographers to shoot in a better quality , giving watchers a chance to take in a greater amount of the stunning work in set plan . Innovation likewise drives whole portions of film now , empowering motion pictures that were impractical some time recently . Here are a few illustrations where innovation has driven film making .
 Film is the favored medium of old fashioned film producers , however it ’s typically too exorbitant for a studio to approve . Film conveys a few hindrances , that smaller person the realness that the film producer is going for . Beside the cost , film is difficult to reuse . That implies a day of shooting must have film the team can utilize , or else each asset devoured that day was a waste . The expenses of film do n’t end the day of shooting either . Cinematographers who utilize film must create it , and after that there is the expensive procedure of altering the film .
 Going computerized generally implies prior the vast canisters of film that used to be synonymous with film making . It likewise implies creation organizations finish their shoot plans with less waste , holding the whole task under or near spending plan .
 After generation is another region where advanced trumps the use of film . Adding visual impacts to film was frequently an exact workmanship , where the impact needed to mix consistently with what was being shot . This was a careful procedure that editors never again experience . Computerized impacts are made and added to the shot inside a similar program or group of projects . This product likewise enables editors to chip away at whole segments of a film , effortlessly sorting scenes out after the after generation impacts are included . That incorporates sound , which now has a top notch advanced record that guarantees the gathering of people will hear each word and activity that they see .
 The final product is a bit of film that looks cleaner , with impacts that mix flawlessly with the motion picture . The group of onlookers more often than not ca n’t tell when CGI has been utilized , however it ’s an effective device film creators have progressively used to set climate .
 Shooting in computerized is considerably simpler on the grounds that you can accomplish more in less time . Different cameras can keep running on a similar shot , so you generally get the point you need without wasting time on retakes . I like shooting carefully on the grounds that it makes it simple . To shoot different takes , and to get various edges all the more monetarily . An executive ’s bread and margarine is pace and execution . I cherish having the capacity to shoot everything . Indeed , with the performing artists ’ authorization , the practices . You never recognize what pieces you ’ll have the capacity to utilize later in altering .
 Combined with the new unfaltering cam hardware that film has favored , the final product is a more cozy shot . The gathering of people feels display at the time on the grounds that the focal point we are permitted to look through feels valid . Film creators likewise invest less energy re - shooting a similar scene to get the correct point .
 The way toward conveying film in computerized has not exactly hit the pinnacle of what it is prepared to do , however the non mainstream film creator particularly stands to pick up . Conveyance through YouTube has been the most well - known type of promoting for a long while . Studios have discharged huge spending trailers , while independent film . Creators have looked for subsidizing and intrigued eyes posting content through different YouTube channels . Obviously , the antagonistic influence is that quality has fundamentally declined , however that is increasingly an element of volume . YouTube clients additionally swarm source what is well known with a thumbs up . The helping other people to discover new and intriguing substance without investing excessively energy burrowing for it .
 Rights to films are now circulated to purchasers carefully , yet this market has not been completely tapped . There is much civil argument with regards to the fate of film utilization . However organizations appear to circulate films on the web . The 2011 film Tower Heist with Ben Stiller was nearly discharged to Comcast clients nearby the dramatic discharge . However the thought was rejected after a few venues debilitated not to demonstrate the film in dissent . Albeit computerized guarantees an energizing new universe of dissemination . The matter of film presently ca n’t seem to get up to speed with this thought .
 The conservation of film is n’t something we consider as shoppers , yet it ’s the very reason despite everything . Film will disintegrate and harm after some time , and it ’s to a great degree combustible as well . There are basically an excessive number of techniques for film to outlast its helpfulness . Advanced films can be put away on organization servers , without taking up excessively space . The expenses to keep up this foundation are additionally lower than the expenses to store and re - ace film .
 Advanced documents are likewise simple to reinforcement and reestablish . Pixar had a now well known occurrence while making Toy Story 2 , where one of the artists lost nearly the whole film taking a shot at it at home because of an awful reinforcement . Beside this little indiscretion , the reinforcement framework has permitted creation . Organizations access to prior forms of a film , and also a source to store shots utilized for dailies .
 Without innovation , it would be almost unthinkable for Hollywood to create the volume of films that it does . Film may be a pleasant idea for that vintage feel , yet the items of common sense of advanced have to a great extent put the film .


text:
– Robust construction for consistantly accurate cuts.
– Bevel cuts to 45 degrees left.
– Pivoting fence provides efficient support to stock.
– Double Insulation, Electric Brake, Bevel Cutting and Dust Collecting. With TCT Wood cutting blade.
– Toolless blade change system. (with electronic control + speed dial).
– Electronic speed control maintains consistant speed set for various workpiece.
– 3 orbital settings plus straight cut.
– Built-in LED job light for easy tracing of cutting line.
– Plastic cover plate can be attached without tool.
– Low vibration and low noise level.
– Double Insulation, Variable Speed, Orbital Cutting, Bayonet Shank, Dust Collecting, Soft Start, Constant Speed, Built-In Light and Carry Case.

tokenized:
– Robust construction for consistantly accurate cuts .
 – Bevel cuts to 45 degrees left .
 – Pivoting fence provides efficient support to stock .
 – Double Insulation , Electric Brake , Bevel Cutting and Dust Collecting . With TCT Wood cutting blade .
 – Toolless blade change system . ( with electronic control + speed dial ) .
 – Electronic speed control maintains consistant speed set for various workpiece .
 – 3 orbital settings plus straight cut .
 – Built - in LED job light for easy tracing of cutting line .
 – Plastic cover plate can be attached without tool .
 – Low vibration and low noise level .
 – Double Insulation , Variable Speed , Orbital Cutting , Bayonet Shank , Dust Collecting , Soft Start , Constant Speed , Built - In Light and Carry Case .


text:
When JRPGs were struggling to evolve last generation, Xenoblade Chronicles came along and showed the genre still had a few tricks up its sleeve. It earned plenty of praise as one of the best role-playing games of last generation, currently holding a 92 score on Metacritic. Monolith Soft proved it could create a compelling world and innovate in the genre, thanks to its creative design and MMO-style combat.
Its successor, Xenoblade Chronicles X, doesn't just switch it up to an extensive sci-fi setting; it expands the scope of everything, building upon the solid foundation set by its predecessor. I recently spent five hours with the game, and I feel like I've barely scratched the surface. If you thought Xenoblade Chronicles was big, you will be surprised just how much Xenoblade Chronicles X dwarfs it - and that's not even mentioning the extensive customization or Skells (mechs) that further enhance the experience.
Not much has been revealed about X's plot, except that a huge battle between two alien species above Earth has destroyed our home planet. Humans evacuated and have spent the past two years roaming space in emergency ships. However, the real story doesn't begin until your main character (you can customize your gender and appearance), crash lands on the planet of Mira. Without much memory of who you are, you're greeted by a woman named Elma, who shows you the ropes of life on this -mysterious continent called Primordia. A rocky grasslands region, Primordia is the first of five different continents that make up Mira.
Elma explains that when their ship, the White Whale, crashed here two months ago, the surviving humans began slowly building New Los Angeles. A good portion of Xenoblade Chronicles' plotline focuses on rebuilding society and finding survivors to revive humanity, but what's most intriguing are the mysteries Mira holds. The planet is teeming with dangers beyond enormous creatures; in fact, as you explore, you run into various alien species. Some will be hostile; others will join your base if you help them out. Can everyone coexist? This already seems more exciting than Xenoblade Chronicles' plot. We always question if there's life on other planets and if it would be friendly or not, and I like how X explores this concept.
Also noticeable right out of the gate is that X's dialogue has much more personality than Xenoblade Chronicles. Your dialogue choices elicit different responses depending on what you pick. These won't alter the storyline, but instead color the conversations you have with other characters. At one point, I try to take credit for keeping the area safe, and Elma quickly calls me on it. Later, we meet our second party member, Lin Lee, a 15-year-old mechanic. She's extremely gifted, but every so often says something that reminds you she's just 15, like when she talks about her Skell fan-fiction. The humor isn't overdone and is clever when it's used. Counting Elma and Lin Lee, a total of 16 characters can be recruited for your party. This includes all the DLC characters released in Japan; Nintendo is including them at no cost in the North American release.
Becoming A Member Of B.L.A.D.E.
The opening moments serve to ease you into the mechanics and all the different things you can do. It's a lot of information to take in, and even after spending five hours with the game, I was still learning the ropes. New Los Angeles, with its four districts, serves as your hub. After a few basic missions, you join up with B.L.A.D.E. (Builders of a Legacy After the Destruction of Earth). This group was created to maintain the burgeoning New Los Angeles and to explore for supplies and threats. Once you join, you get to pick from one of eight different classes, from mediators who help the townspeople to reclaimers who search for wreckage from the White Whale. Every class comes with its own perks, and just because you pick a class doesn't mean you can't do activities associated with others; this just gives you an area to focus on for potential upgrades for your character. Throughout the game, you earn division points for defeating enemies, completing missions, and opening chests. Bonus division points are awarded if you do missions in your specialization. Division points allow you to level up your B.L.A.D.E. rank, which grants you additional rewards and higher level probes.
B.L.A.D.E. has its own mission board, where you can retrieve different job requests. From the get-go, the board is overflowing with a variety of missions, on top of people handing you tasks. More than 400 quests exist, including story missions that advance the plot, affinity missions that improve your relationship with characters, and normal side quests such as rescuing characters or retrieving items. The narrative has a total of 12 chapters, but you can't advance unless you meet certain requirements. For instance, you might need to reach a specific affinity level with a character or explore 15 percent of the continent to proceed.
A variety of activities are available in Xenoblade X's vast open world, and they fit seamlessly into the overall exploration, such as placing probes (which also opens fast travel to those locations) and helping characters in peril. Who knows? Maybe you'll run into members of a new species and convince them to join up with you. At one point, I recruited a species and I was given access to brand-new weaponry.
One side quest tasked me with obtaining a red orb that was inconveniently placed in front of two level 35 tyrants. I was level five at the time, so there was no way I could afford to draw their attention my way, forcing me to slowly walk by them and figure out a way to stay out of their sight.
Various chests and places to mine resources are uncovered as you explore. You must tap "A" repeatedly to open these, but some chests remain locked until you level up this ability. Returning from Xenoblade are orbs littered on the field, which contain additional items. The jump button allows you to get up on higher ledges, but if you use it while running you can do a super jump that lets you float through the air. This quickly became my favorite way to explore.
All sorts of creatures inhabit the land, be they aggressive, neutral, or friendly. Paying attention to the color above them is essential; if it's red, you need to keep your awareness up. The joy of the game really stems from exploration; majestic, dinosaur-like creatures are all around. Other continents sport completely different looks. For instance, one is a jungle and contains alligators that leap out from the water to attack you. Another is a fire island that rains fire and allows you to explore inside volcanoes.
Each locale is filled with nooks and crannies, but quests leave a marker for you to track down. Better yet, after a few missions, you unlock the "follow ball." All you need to do is hold "R" and press "X," and a navigational ball leads you to your destination. This comes in handy when there are mountains or other obstacles in your way, showing you a fast path to get around them.
In addition to the single-player campaign, Xenoblade Chronicles X has two different online features. You can recruit other player-created character NPCs, who can then be used in your party. You also build affinity with these NPC rentals on the battlefield. However, the more exciting online feature is the ability to join squads. Squads hold 32 players and allow you to participate in squad quests, which let you team up with three other players to take on tougher content, such as the gigantic, super-powerful tyrants.
Before you can unlock squad quests, however, you must first complete squad missions. These special objectives need to be completed in a certain amount of time. All squad members see the list and once a member completes something on it, it gets marked as completed in the other squad members’ games. This allows you to divvy up tasks as you see fit. You can also exchange loot with your squad, so if you get gear or weapons that don’t suit your playstyle, you can let your friend reap the benefits.
Xenoblade Chronicles X's battle system doesn't change significantly from its predecessor. You activate skills on a cooldown meter while your character automatically uses regular attacks, akin to an MMORPG. But the battles are noticeably faster and smoother than before, something Monolith executive director Tetsuya Takahashi said was born out of this game having longer conflicts. "[We] wanted the pace of the combat to be faster, so those don't last too long," he says.
I took delight in finding the right grooves of attacks to create deadly combos. Positioning still matters greatly, and every art has a positioning bonus. For instance, an art bonus can provide a damage increase for a side attack, or a specific art may add a 50-percent damage bonus if the enemy is toppled. You can combine these for devastating combos.
Additionally, I enjoyed being able to alternate between melee and ranged attacks. My character had a deadly sword I could use up close, but if I wanted to play it safer, I could always swap to my gun and snipe from afar. I actually preferred the guns to the sword for this reason - and let's be honest, lasers are just cooler. The A.I. is also much better this time around; my allies rarely died and knew when to fall back and heal.
Arts can be customized to fit your playstyle. For the start of the game, you are a drifter that allows you to obtain a variety of different arts. Once you reach level 10, you have different branches you can break off into: enforcer, striker, and guerrilla. Enforcers support from afar, gaining access to a slew of ranged arts. Guerillas are like tanks who want to rack up damage; their arts are focused on damage buffs, evasion, and improved accuracy. Strikers go in guns blazing and are a mix of offensive and defensive skills, providing HP and melee power bonuses. The striker is the recommended class for beginners, while the enforcer is for more experienced players.
Those expecting to hop right into a mech might be disappointed; you don't get your Skell license until chapter six, halfway through the game. You also won't receive your first Skell until level 20, and you can't pilot it until researching the flight pack after chapter nine. "The main reason we didn't want players to have the Skell from the beginning of the game is that we wanted them to have the opportunity to fully explore the world on foot first," Takahashi says. "The world starts to feel quite a bit different once you have the Skell, especially once you experience different layers of the world vertically."
Nintendo skipped me ahead so I could test one out. Skells definitely make exploration a different beast; you can fly to floating islands and some structures have hidden caves that can only be accessed via flight. Skells also make journeying between continents much easier - I didn't even care about fast travel once I got mine.
Stepping into X is overwhelming for its sheer vastness and scope alone, but that's what makes it so thrilling. The game feels endless, but my desire to keep on playing and discovering new things never left me. My early look has me confident that this game will inspire massive playthroughs just like its predecessor, but X feels like it has even more to offer in terms of variety and size. Plus, who isn't excited to see Takahashi and company get back to their sci-fi roots à la Xenogears and Xenosaga?
Xenoblade Chronicles X also has plenty of late-game content to make your Skell worthwhile. It features numerous post-game monsters, like a level 99 baddie soaring in the sky, and online play makes it possible to take down deadly foes with friends. In addition, hidden dungeons, higher-level mechs, and powerful gear and weapons provide extra incentive to keep exploring. “One figure we’re hearing from people [in Japan] is that they’ve spent two to three times the amount of hours they spent on clearing the main story on end-game content,” says Monolith Soft executive director Tetsuya Takahashi.

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When JRPGs were struggling to evolve last generation , Xenoblade Chronicles came along and showed the genre still had a few tricks up its sleeve . It earned plenty of praise as one of the best role - playing games of last generation , currently holding a 92 score on Metacritic . Monolith Soft proved it could create a compelling world and innovate in the genre , thanks to its creative design and MMO - style combat .
 Its successor , Xenoblade Chronicles X , does n't just switch it up to an extensive sci - fi setting ; it expands the scope of everything , building upon the solid foundation set by its predecessor . I recently spent five hours with the game , and I feel like I 've barely scratched the surface . If you thought Xenoblade Chronicles was big , you will be surprised just how much Xenoblade Chronicles X dwarfs it - and that 's not even mentioning the extensive customization or Skells ( mechs ) that further enhance the experience .
 Not much has been revealed about X 's plot , except that a huge battle between two alien species above Earth has destroyed our home planet . Humans evacuated and have spent the past two years roaming space in emergency ships . However , the real story does n't begin until your main character ( you can customize your gender and appearance ) , crash lands on the planet of Mira . Without much memory of who you are , you 're greeted by a woman named Elma , who shows you the ropes of life on this -mysterious continent called Primordia . A rocky grasslands region , Primordia is the first of five different continents that make up Mira .
 Elma explains that when their ship , the White Whale , crashed here two months ago , the surviving humans began slowly building New Los Angeles . A good portion of Xenoblade Chronicles ' plotline focuses on rebuilding society and finding survivors to revive humanity , but what 's most intriguing are the mysteries Mira holds . The planet is teeming with dangers beyond enormous creatures ; in fact , as you explore , you run into various alien species . Some will be hostile ; others will join your base if you help them out . Can everyone coexist ? This already seems more exciting than Xenoblade Chronicles ' plot . We always question if there 's life on other planets and if it would be friendly or not , and I like how X explores this concept .
 Also noticeable right out of the gate is that X 's dialogue has much more personality than Xenoblade Chronicles . Your dialogue choices elicit different responses depending on what you pick . These wo n't alter the storyline , but instead color the conversations you have with other characters . At one point , I try to take credit for keeping the area safe , and Elma quickly calls me on it . Later , we meet our second party member , Lin Lee , a 15 - year - old mechanic . She 's extremely gifted , but every so often says something that reminds you she 's just 15 , like when she talks about her Skell fan - fiction . The humor is n't overdone and is clever when it 's used . Counting Elma and Lin Lee , a total of 16 characters can be recruited for your party . This includes all the DLC characters released in Japan ; Nintendo is including them at no cost in the North American release .
 Becoming A Member Of B.L.A.D.E.
 The opening moments serve to ease you into the mechanics and all the different things you can do . It 's a lot of information to take in , and even after spending five hours with the game , I was still learning the ropes . New Los Angeles , with its four districts , serves as your hub . After a few basic missions , you join up with B.L.A.D.E. ( Builders of a Legacy After the Destruction of Earth ) . This group was created to maintain the burgeoning New Los Angeles and to explore for supplies and threats . Once you join , you get to pick from one of eight different classes , from mediators who help the townspeople to reclaimers who search for wreckage from the White Whale . Every class comes with its own perks , and just because you pick a class does n't mean you ca n't do activities associated with others ; this just gives you an area to focus on for potential upgrades for your character . Throughout the game , you earn division points for defeating enemies , completing missions , and opening chests . Bonus division points are awarded if you do missions in your specialization . Division points allow you to level up your B.L.A.D.E. rank , which grants you additional rewards and higher level probes .
 B.L.A.D.E. has its own mission board , where you can retrieve different job requests . From the get - go , the board is overflowing with a variety of missions , on top of people handing you tasks . More than 400 quests exist , including story missions that advance the plot , affinity missions that improve your relationship with characters , and normal side quests such as rescuing characters or retrieving items . The narrative has a total of 12 chapters , but you ca n't advance unless you meet certain requirements . For instance , you might need to reach a specific affinity level with a character or explore 15 percent of the continent to proceed .
 A variety of activities are available in Xenoblade X 's vast open world , and they fit seamlessly into the overall exploration , such as placing probes ( which also opens fast travel to those locations ) and helping characters in peril . Who knows ? Maybe you 'll run into members of a new species and convince them to join up with you . At one point , I recruited a species and I was given access to brand - new weaponry .
 One side quest tasked me with obtaining a red orb that was inconveniently placed in front of two level 35 tyrants . I was level five at the time , so there was no way I could afford to draw their attention my way , forcing me to slowly walk by them and figure out a way to stay out of their sight .
 Various chests and places to mine resources are uncovered as you explore . You must tap " A " repeatedly to open these , but some chests remain locked until you level up this ability . Returning from Xenoblade are orbs littered on the field , which contain additional items . The jump button allows you to get up on higher ledges , but if you use it while running you can do a super jump that lets you float through the air . This quickly became my favorite way to explore .
 All sorts of creatures inhabit the land , be they aggressive , neutral , or friendly . Paying attention to the color above them is essential ; if it 's red , you need to keep your awareness up . The joy of the game really stems from exploration ; majestic , dinosaur - like creatures are all around . Other continents sport completely different looks . For instance , one is a jungle and contains alligators that leap out from the water to attack you . Another is a fire island that rains fire and allows you to explore inside volcanoes .
 Each locale is filled with nooks and crannies , but quests leave a marker for you to track down . Better yet , after a few missions , you unlock the " follow ball . " All you need to do is hold " R " and press " X , " and a navigational ball leads you to your destination . This comes in handy when there are mountains or other obstacles in your way , showing you a fast path to get around them .
 In addition to the single - player campaign , Xenoblade Chronicles X has two different online features . You can recruit other player - created character NPCs , who can then be used in your party . You also build affinity with these NPC rentals on the battlefield . However , the more exciting online feature is the ability to join squads . Squads hold 32 players and allow you to participate in squad quests , which let you team up with three other players to take on tougher content , such as the gigantic , super - powerful tyrants .
 Before you can unlock squad quests , however , you must first complete squad missions . These special objectives need to be completed in a certain amount of time . All squad members see the list and once a member completes something on it , it gets marked as completed in the other squad members ’ games . This allows you to divvy up tasks as you see fit . You can also exchange loot with your squad , so if you get gear or weapons that do n’t suit your playstyle , you can let your friend reap the benefits .
 Xenoblade Chronicles X 's battle system does n't change significantly from its predecessor . You activate skills on a cooldown meter while your character automatically uses regular attacks , akin to an MMORPG . But the battles are noticeably faster and smoother than before , something Monolith executive director Tetsuya Takahashi said was born out of this game having longer conflicts . " [ We ] wanted the pace of the combat to be faster , so those do n't last too long , " he says .
 I took delight in finding the right grooves of attacks to create deadly combos . Positioning still matters greatly , and every art has a positioning bonus . For instance , an art bonus can provide a damage increase for a side attack , or a specific art may add a 50 - percent damage bonus if the enemy is toppled . You can combine these for devastating combos .
 Additionally , I enjoyed being able to alternate between melee and ranged attacks . My character had a deadly sword I could use up close , but if I wanted to play it safer , I could always swap to my gun and snipe from afar . I actually preferred the guns to the sword for this reason - and let 's be honest , lasers are just cooler . The A.I. is also much better this time around ; my allies rarely died and knew when to fall back and heal .
 Arts can be customized to fit your playstyle . For the start of the game , you are a drifter that allows you to obtain a variety of different arts . Once you reach level 10 , you have different branches you can break off into : enforcer , striker , and guerrilla . Enforcers support from afar , gaining access to a slew of ranged arts . Guerillas are like tanks who want to rack up damage ; their arts are focused on damage buffs , evasion , and improved accuracy . Strikers go in guns blazing and are a mix of offensive and defensive skills , providing HP and melee power bonuses . The striker is the recommended class for beginners , while the enforcer is for more experienced players .
 Those expecting to hop right into a mech might be disappointed ; you do n't get your Skell license until chapter six , halfway through the game . You also wo n't receive your first Skell until level 20 , and you ca n't pilot it until researching the flight pack after chapter nine . " The main reason we did n't want players to have the Skell from the beginning of the game is that we wanted them to have the opportunity to fully explore the world on foot first , " Takahashi says . " The world starts to feel quite a bit different once you have the Skell , especially once you experience different layers of the world vertically . "
 Nintendo skipped me ahead so I could test one out . Skells definitely make exploration a different beast ; you can fly to floating islands and some structures have hidden caves that can only be accessed via flight . Skells also make journeying between continents much easier - I did n't even care about fast travel once I got mine .
 Stepping into X is overwhelming for its sheer vastness and scope alone , but that 's what makes it so thrilling . The game feels endless , but my desire to keep on playing and discovering new things never left me . My early look has me confident that this game will inspire massive playthroughs just like its predecessor , but X feels like it has even more to offer in terms of variety and size . Plus , who is n't excited to see Takahashi and company get back to their sci - fi roots à la Xenogears and Xenosaga ?
 Xenoblade Chronicles X also has plenty of late - game content to make your Skell worthwhile . It features numerous post - game monsters , like a level 99 baddie soaring in the sky , and online play makes it possible to take down deadly foes with friends . In addition , hidden dungeons , higher - level mechs , and powerful gear and weapons provide extra incentive to keep exploring . “ One figure we ’re hearing from people [ in Japan ] is that they ’ve spent two to three times the amount of hours they spent on clearing the main story on end - game content , ” says Monolith Soft executive director Tetsuya Takahashi .


text:
Extension allows you to set different colors in vTiger’s lists. For example Paid Invoices can be in green but lost Deals can be in red. Using this vTiger extensions you can create a lot of different colors in CRM. The colors works in related lists too.
Extension allows you to set different colors in vTiger’s lists. For example Paid Invoices can be in green but lost Deals can be in red. Use this vTiger extensions you can create a lot of different colors in CRM. The colors works in related lists too.
Extension shows related list's items quantity in Summary or Detail view.

tokenized:
Extension allows you to set different colors in vTiger ’s lists . For example Paid Invoices can be in green but lost Deals can be in red . Using this vTiger extensions you can create a lot of different colors in CRM . The colors works in related lists too .
 Extension allows you to set different colors in vTiger ’s lists . For example Paid Invoices can be in green but lost Deals can be in red . Use this vTiger extensions you can create a lot of different colors in CRM . The colors works in related lists too .
 Extension shows related list 's items quantity in Summary or Detail view .


text:
1. Alternatively referred to as three-dimensional, 3-D or 3D is a description of a visual object that has the appearance of depth and field. The picture is an example of a 3D ball that is overlaying a wireframe.
Tip: A great example of a free, open source 3D program, for anyone interested in the field of graphics and animation, is Blender.
Should I use "3D" or "3-D" in my writing?
Today, both versions of "3-D" and "3D" are widely used and vary depending on the style guide you follow. We follow the Microsoft Manual of Style and use "3-D" (with a hyphen) in our writing unless "3D" is part of a product name.
2. A 3-D accelerator is a graphics card with additional processing power and memory for improving the performance and enhancing the appearance of 3-D images. See our graphics accelerator for further information.
3. When referring to audio, 3-D is a method of describing sound that is seemingly coming from all directions.

tokenized:
1 . Alternatively referred to as three - dimensional , 3 - D or 3D is a description of a visual object that has the appearance of depth and field . The picture is an example of a 3D ball that is overlaying a wireframe .
 Tip : A great example of a free , open source 3D program , for anyone interested in the field of graphics and animation , is Blender .
 Should I use " 3D " or " 3 - D " in my writing ?
 Today , both versions of " 3 - D " and " 3D " are widely used and vary depending on the style guide you follow . We follow the Microsoft Manual of Style and use " 3 - D " ( with a hyphen ) in our writing unless " 3D " is part of a product name .
 2 . A 3 - D accelerator is a graphics card with additional processing power and memory for improving the performance and enhancing the appearance of 3 - D images . See our graphics accelerator for further information .
 3 . When referring to audio , 3 - D is a method of describing sound that is seemingly coming from all directions .


text:
Central nervous system (CNS) disorders like multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, epilepsy, as well as psychiatric disorders have treatment options, but many have to cross the blood-brain barrier and in doing so can lose potency.
With therapeutics for CNS disorders being both small molecules and biologics, vehicles to deliver the drug to the CNS is the biggest challenge. However, innovations like intranasal administration and viral vector systems are being put to work.
To uncover some of the challenges and innovations occurring in CNS, BioPharma-Reporter (BPR) spoke with Raj Mehra (RM), CEO of Seelos Therapeutics, a clinical-stage biopharmaceutical company focused on therapeutics for such disorders.
RM: Some of the biological approaches have been proven to be ineffective, not because of efficacy but because the drug delivery systems are not able to get enough of the drugs across the blood-brain barrier.
An approach that has been advanced is the vector system, that’s one way to get delivery where you want it [to the CNS]. However, it has some side effects – issues that need to get flushed out in the next few years.
The other approach that looks very promising, and few have explored until now, is getting the drugs administered intranasally.
Whether the drug is in a liquid formulation or solid, you can practically put those [formulations] in a device that can [be administered in an] intranasal spray.
What we’ve seen is that it is one of the quickest and fastest ways to get the drug into the CNS by bypassing the gastrointestinal effect, and a smaller dose can provide a much better efficacy. Fast-acting drugs delivered intranasally are going to be a big trend.
RM: People did not think about it, people thought that if a drug is not orally available, “How about coming up with a subcutaneous delivery or come out with a patch?” The patches had mixed records, but subcutaneous delivery has a decent record.
When people tried to address the CNS space, they realized its limitations. If you were to do an antibody approach [to address the CNS then] you’d need a large amount of dosing to assume that .1% will eventually cross the blood-brain barrier. So, that approach limitation is what made people start thinking: “Can we pursue other approaches in the intranasal formulation?”, and people saw remarkable efficacy.
One of the approaches to address aggregates in the CNS disease is an antibody approach – which are large biologicals.
The issue was when you have an antibody approach, they have created antibodies that are very specific disease aggregates, only leaving the monomers alone which are needed for the body, and contains and reduces these aggregates (i.e. you can have a disease-modifying potential for a disease like Parkinson’s).
That [disease modifying potential] we have been waiting and hoping for forever. The issue that we saw there is that antibodies do not cross the blood-brain barrier easily; so if you were to come up with a 20g dose, you hope to get 20mg into the CNS.
So, that’s one approach and the other approach is a small molecule approach. We are going to pursue a small molecule approach where you don’t need the high dose, and the delivery mechanism could be either intranasal or it could be a vector approach -- but these things need to be worked upon.
But that’s what we are looking forward to because up until now all the therapies available for Parkinson’s were just treating the symptoms – none of them were stopping the disease or halting the progression. Now we understand it but the challenge [remains] the delivery mechanism.
RM: It’s becoming more like a drug and device – you don’t just have a pill that you deliver orally, you have a drug that needs to be formulated for a device.
On the formulation side, it always comes back to the same old issue: if your drug is small molecule than it’s relatively easy to fit into the transporters because your drug is either water-soluble, or it is not soluble but you can come up with nanoparticles and new technologies that can make it palatable for it to be transported to the CNS.
However, the biologics will have some challenges. These transporter systems [needed for the CNS innovations], generally speaking, have a limitation as you can’t have a big biologic easily available to be transported.
So, the challenge will be most of the work that should be done on the CNS side for formulation -- coming up with a relatively small footprint of the drug that can be easily put into the vehicle.
You will have those inherent limitations until down the road, perhaps, we can overcome that. So, the formulations have to be relatively small footprint therapies.
RM: I think we need to urge our large pharma companies to step up to the plate and not just remain focused on oncology because the CNS diseases are becoming much more prevalent and as deadly.

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Central nervous system ( CNS ) disorders like multiple sclerosis , Alzheimer ’s disease , Parkinson ’s disease , epilepsy , as well as psychiatric disorders have treatment options , but many have to cross the blood - brain barrier and in doing so can lose potency .
 With therapeutics for CNS disorders being both small molecules and biologics , vehicles to deliver the drug to the CNS is the biggest challenge . However , innovations like intranasal administration and viral vector systems are being put to work .
 To uncover some of the challenges and innovations occurring in CNS , BioPharma - Reporter ( BPR ) spoke with Raj Mehra ( RM ) , CEO of Seelos Therapeutics , a clinical - stage biopharmaceutical company focused on therapeutics for such disorders .
 RM: Some of the biological approaches have been proven to be ineffective , not because of efficacy but because the drug delivery systems are not able to get enough of the drugs across the blood - brain barrier .
 An approach that has been advanced is the vector system , that ’s one way to get delivery where you want it [ to the CNS ] . However , it has some side effects – issues that need to get flushed out in the next few years .
 The other approach that looks very promising , and few have explored until now , is getting the drugs administered intranasally .
 Whether the drug is in a liquid formulation or solid , you can practically put those [ formulations ] in a device that can [ be administered in an ] intranasal spray .
 What we ’ve seen is that it is one of the quickest and fastest ways to get the drug into the CNS by bypassing the gastrointestinal effect , and a smaller dose can provide a much better efficacy . Fast - acting drugs delivered intranasally are going to be a big trend .
 RM: People did not think about it , people thought that if a drug is not orally available , “ How about coming up with a subcutaneous delivery or come out with a patch ? ” The patches had mixed records , but subcutaneous delivery has a decent record .
 When people tried to address the CNS space , they realized its limitations . If you were to do an antibody approach [ to address the CNS then ] you ’d need a large amount of dosing to assume that .1 % will eventually cross the blood - brain barrier . So , that approach limitation is what made people start thinking : “ Can we pursue other approaches in the intranasal formulation ? ” , and people saw remarkable efficacy .
 One of the approaches to address aggregates in the CNS disease is an antibody approach – which are large biologicals .
 The issue was when you have an antibody approach , they have created antibodies that are very specific disease aggregates , only leaving the monomers alone which are needed for the body , and contains and reduces these aggregates ( i.e. you can have a disease - modifying potential for a disease like Parkinson ’s ) .
 That [ disease modifying potential ] we have been waiting and hoping for forever . The issue that we saw there is that antibodies do not cross the blood - brain barrier easily ; so if you were to come up with a 20 g dose , you hope to get 20 mg into the CNS .
 So , that ’s one approach and the other approach is a small molecule approach . We are going to pursue a small molecule approach where you do n’t need the high dose , and the delivery mechanism could be either intranasal or it could be a vector approach -- but these things need to be worked upon .
 But that ’s what we are looking forward to because up until now all the therapies available for Parkinson ’s were just treating the symptoms – none of them were stopping the disease or halting the progression . Now we understand it but the challenge [ remains ] the delivery mechanism .
 RM: It ’s becoming more like a drug and device – you do n’t just have a pill that you deliver orally , you have a drug that needs to be formulated for a device .
 On the formulation side , it always comes back to the same old issue : if your drug is small molecule than it ’s relatively easy to fit into the transporters because your drug is either water - soluble , or it is not soluble but you can come up with nanoparticles and new technologies that can make it palatable for it to be transported to the CNS .
 However , the biologics will have some challenges . These transporter systems [ needed for the CNS innovations ] , generally speaking , have a limitation as you ca n’t have a big biologic easily available to be transported .
 So , the challenge will be most of the work that should be done on the CNS side for formulation -- coming up with a relatively small footprint of the drug that can be easily put into the vehicle .
 You will have those inherent limitations until down the road , perhaps , we can overcome that . So , the formulations have to be relatively small footprint therapies .
 RM: I think we need to urge our large pharma companies to step up to the plate and not just remain focused on oncology because the CNS diseases are becoming much more prevalent and as deadly .


text:
Add chlorine or all-fabric bleach, if possible. How to Get Candle Wax Out of Carpet. If the wax is still soft, freeze it by applying an ice cube wrapped in a small plastic bag, and then scrape off... 28/12/2006 · Best Answer: Using an ice cube in a bag cool the wax so it will chip off easily then soak up residual wax by putting some paper towels over the stain and heating with an iron keep using fresh papertowels and heating until stain is gone.
28/12/2006 · Best Answer: Using an ice cube in a bag cool the wax so it will chip off easily then soak up residual wax by putting some paper towels over the stain and heating with an iron keep using fresh papertowels and heating until stain is gone.

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Add chlorine or all - fabric bleach , if possible . How to Get Candle Wax Out of Carpet . If the wax is still soft , freeze it by applying an ice cube wrapped in a small plastic bag , and then scrape off ... 28/12/2006 · Best Answer : Using an ice cube in a bag cool the wax so it will chip off easily then soak up residual wax by putting some paper towels over the stain and heating with an iron keep using fresh papertowels and heating until stain is gone .
 28/12/2006 · Best Answer : Using an ice cube in a bag cool the wax so it will chip off easily then soak up residual wax by putting some paper towels over the stain and heating with an iron keep using fresh papertowels and heating until stain is gone .


text:
What happen to my face?!
I got a new pet!
UGH! My mind is killing me!

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What happen to my face ? !
 I got a new pet !
 UGH ! My mind is killing me !


text:
You can get some seriously wonderful candle chandeliers - either to hang from the ceiling or some that stand on the floor as a large centrepiece.
I have seen a few ( some very, very expensive! ) that I would just love to stock. At the moment I have not yet taken the plunge, but watch this space!
In the mean time have a look at some in the Daily Telegraphs site www.telegraph.co.uk. So much better than the electric light version!

tokenized:
You can get some seriously wonderful candle chandeliers - either to hang from the ceiling or some that stand on the floor as a large centrepiece .
 I have seen a few ( some very , very expensive ! ) that I would just love to stock . At the moment I have not yet taken the plunge , but watch this space !
 In the mean time have a look at some in the Daily Telegraphs site www.telegraph.co.uk . So much better than the electric light version !


text:
If your air conditioner was installed before 2010 and you don’t know what R22 is then you should probably find out more. R22 refrigerant is a chemical that keeps the air coming from your air conditioning system cool, so it’s certainly incredibly important. Most air conditioning units older than 10 years have an AC refrigerant called R22 that’s commonly identified as Freon*, and is referred to by the EPA as HCFC-22. In this blog, we’ll use the name R22. This refrigerant was introduced in the 1950s and became the leading AC refrigerant in the residential heating and cooling industry.
Several decades later the world realized that R22 refrigerant was aiding in the depletion of the Earth’s ozone layer. That’s not great. So, the U.S. EPA, in cooperation with other agencies and groups around the world, initiated a phase out of several ozone-depleting agents as part of an international agreement known as the Montreal Protocol. The regulation lists many HCFCs and CFCs (different types of refrigerants that deplete the ozone layer), but R22 is considered one of the worst offenders.
In 2003, the phase out of R22 production and imports commenced. By the beginning of 2010 the production and import of R22 became prohibited. However, servicing current, existing equipment is still allowed while there is an available supply of R22. To confirm the public’s compliance with the new law, all sales of R22 must be bought by a certified technician. Production and import of R22 will be continually reduced by law until 2020, when all production and import will be eliminated. Only recycled R22 refrigerant will be obtainable to service existing air conditioners after 2020.
If this sounds like a case study on supply and demand, then you are on the right track. As you might assume, older air conditioners more often have leaks and need repairs. Any air conditioners that are older than 2010 are more likely to use R22, which means there’s a lot more demand for it, and a restricted supply. Prices have only increased due to scarcity.
Recall that in order to obtain R22, you’ll need to be an EPA-certified technician. So, the average homeowner isn’t able to purchase a cylinder themselves. Plus, there are some stern regulations now on how refrigerant should be reclaimed and recycled, which raises the price. This expense is passed on to the homeowner as companies are forced to cover the increased overhead related to R22 repairs. There are requirements for importing, labeling, record keeping, reporting, destruction and reclaiming of R22 from existing systems.
The cost of R22 is considerably increasing because of the diminishing supply, and new refrigerant will no longer be available for use at all after 2020, except from recycled quantities.
If you’re thinking, “Wow, this is starting to sound expensive,” you’re correct, it is. This is why when our technicians come out to review your unit we check to see what refrigerant your unit uses, and lots of cases, we’ll advocate for an upgrade as a result of the increasing cost of sustaining an R22 air conditioner.
If you have an air conditioning system that was built before 2010, your AC will typically have R22. However, if you installed your air conditioner after January 1, 2010, then your system may not have R22. You can check the type of refrigerant your system runs on by checking the appliance’s nameplate. This nameplate is usually found on the outdoor condenser of your central air conditioning system. If you can’t locate it, you can grab your user’s manual. Otherwise, you can contact your local Service Experts center. If you have a maintenance agreement with us, we also have your information on hand and a tech can let you know right away if your unit uses R22.
The industry has changed from R22 to R410a, which you may recognize by the brand name Puron. Throughout this article, we’ll use the name R410a (although Puron is a familiar brand, there are other companies that make R410a). There are some key benefits to switching from an R22 air conditioning unit to one that uses R410a. It provides a higher safety rating and an ozone depletion rating of zero, and it performed slightly better on energy-efficiency tests than R22.
You may have read about “drop-in” replacements for R22. We strongly against against this route. Usually a homeowner who is anxious about the cost of replacing their unit seeks out an alternative, and this sounds like an easy solution. It typically costs the homeowner more money, and virtually always voids the manufacturer warranty. The truth about “drop-ins” is that there is no “drop-in” solution where you simply swap out the refrigerant. The phrase “drop-in” is referring to retrofitting a unit, which when done right can cost the homeowner as much, or more, money than purchasing a new unit that uses R410a. In part, this is because different refrigerants function at different pressure levels and require different parts to run, which forces the technician to replace the most expensive components of your system to fit with the new refrigerant. If this critical step is avoided, your system will quickly stop working, and you’ll be forced to install a new unit anyway.
Your manufacturer will typically not pay for the parts to make this transition because retrofitting your AC system will likely void the warranty. It’s typically just a temporary fix, but purchasing a new upgraded AC system will probably benefit most homeowners in dependability, satisfaction, and long-term comfort.
It’s smart to discuss pricing offers with your HVAC provider if you’re concerned about cost. At Service Experts Heating & Air Conditioning, we have financing available that makes a replacement affordable, and we watch for any manufacturer and utility rebates that would make it easier to swallow a surprising replacement. To reduce the chances of an emergency on a hot day, lots of our customers choose to do a pre-emptive replacement, and replace an old unit before it breaks down. If you’re considering that route as well, then you’re in good company!
If your heating and air conditioning system was built after January 2010, the R22 phase out problem may not apply to you, because it’s likely that your system uses the new, approved replacement refrigerant, R410a. However, systems installed after 2010 could potentially use R22, so it’s ideal to check with an HVAC Expert. You can always look for and the refrigerant type by reading the nameplate on your condenser (the condenser is the outside unit).
To be clear, the EPA regulates the production and use of this refrigerant, but not your unit. You are not required by the law to replace your air conditioner. Ultimately, your AC will quit running and it will need to be replaced, and only R410a units will be available for sale.
The best option is to buy a new, upgraded air conditioner, specifically if your current air conditioner is already more than 10 years old. Service Experts Heating & Air Conditioning has lots of financing options that help to meet your budget, and again, we look out for rebates from HVAC manufacturers and local utilities to make it even easier. New AC equipment will also be more efficient and offer you superior comfort, helping to reduce your energy costs.

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If your air conditioner was installed before 2010 and you do n’t know what R22 is then you should probably find out more . R22 refrigerant is a chemical that keeps the air coming from your air conditioning system cool , so it ’s certainly incredibly important . Most air conditioning units older than 10 years have an AC refrigerant called R22 that ’s commonly identified as Freon * , and is referred to by the EPA as HCFC-22 . In this blog , we ’ll use the name R22 . This refrigerant was introduced in the 1950s and became the leading AC refrigerant in the residential heating and cooling industry .
 Several decades later the world realized that R22 refrigerant was aiding in the depletion of the Earth ’s ozone layer . That ’s not great . So , the U.S. EPA , in cooperation with other agencies and groups around the world , initiated a phase out of several ozone - depleting agents as part of an international agreement known as the Montreal Protocol . The regulation lists many HCFCs and CFCs ( different types of refrigerants that deplete the ozone layer ) , but R22 is considered one of the worst offenders .
 In 2003 , the phase out of R22 production and imports commenced . By the beginning of 2010 the production and import of R22 became prohibited . However , servicing current , existing equipment is still allowed while there is an available supply of R22 . To confirm the public ’s compliance with the new law , all sales of R22 must be bought by a certified technician . Production and import of R22 will be continually reduced by law until 2020 , when all production and import will be eliminated . Only recycled R22 refrigerant will be obtainable to service existing air conditioners after 2020 .
 If this sounds like a case study on supply and demand , then you are on the right track . As you might assume , older air conditioners more often have leaks and need repairs . Any air conditioners that are older than 2010 are more likely to use R22 , which means there ’s a lot more demand for it , and a restricted supply . Prices have only increased due to scarcity .
 Recall that in order to obtain R22 , you ’ll need to be an EPA - certified technician . So , the average homeowner is n’t able to purchase a cylinder themselves . Plus , there are some stern regulations now on how refrigerant should be reclaimed and recycled , which raises the price . This expense is passed on to the homeowner as companies are forced to cover the increased overhead related to R22 repairs . There are requirements for importing , labeling , record keeping , reporting , destruction and reclaiming of R22 from existing systems .
 The cost of R22 is considerably increasing because of the diminishing supply , and new refrigerant will no longer be available for use at all after 2020 , except from recycled quantities .
 If you ’re thinking , “ Wow , this is starting to sound expensive , ” you ’re correct , it is . This is why when our technicians come out to review your unit we check to see what refrigerant your unit uses , and lots of cases , we ’ll advocate for an upgrade as a result of the increasing cost of sustaining an R22 air conditioner .
 If you have an air conditioning system that was built before 2010 , your AC will typically have R22 . However , if you installed your air conditioner after January 1 , 2010 , then your system may not have R22 . You can check the type of refrigerant your system runs on by checking the appliance ’s nameplate . This nameplate is usually found on the outdoor condenser of your central air conditioning system . If you ca n’t locate it , you can grab your user ’s manual . Otherwise , you can contact your local Service Experts center . If you have a maintenance agreement with us , we also have your information on hand and a tech can let you know right away if your unit uses R22 .
 The industry has changed from R22 to R410a , which you may recognize by the brand name Puron . Throughout this article , we ’ll use the name R410a ( although Puron is a familiar brand , there are other companies that make R410a ) . There are some key benefits to switching from an R22 air conditioning unit to one that uses R410a . It provides a higher safety rating and an ozone depletion rating of zero , and it performed slightly better on energy - efficiency tests than R22 .
 You may have read about “ drop - in ” replacements for R22 . We strongly against against this route . Usually a homeowner who is anxious about the cost of replacing their unit seeks out an alternative , and this sounds like an easy solution . It typically costs the homeowner more money , and virtually always voids the manufacturer warranty . The truth about “ drop - ins ” is that there is no “ drop - in ” solution where you simply swap out the refrigerant . The phrase “ drop - in ” is referring to retrofitting a unit , which when done right can cost the homeowner as much , or more , money than purchasing a new unit that uses R410a . In part , this is because different refrigerants function at different pressure levels and require different parts to run , which forces the technician to replace the most expensive components of your system to fit with the new refrigerant . If this critical step is avoided , your system will quickly stop working , and you ’ll be forced to install a new unit anyway .
 Your manufacturer will typically not pay for the parts to make this transition because retrofitting your AC system will likely void the warranty . It ’s typically just a temporary fix , but purchasing a new upgraded AC system will probably benefit most homeowners in dependability , satisfaction , and long - term comfort .
 It ’s smart to discuss pricing offers with your HVAC provider if you ’re concerned about cost . At Service Experts Heating & Air Conditioning , we have financing available that makes a replacement affordable , and we watch for any manufacturer and utility rebates that would make it easier to swallow a surprising replacement . To reduce the chances of an emergency on a hot day , lots of our customers choose to do a pre - emptive replacement , and replace an old unit before it breaks down . If you ’re considering that route as well , then you ’re in good company !
 If your heating and air conditioning system was built after January 2010 , the R22 phase out problem may not apply to you , because it ’s likely that your system uses the new , approved replacement refrigerant , R410a . However , systems installed after 2010 could potentially use R22 , so it ’s ideal to check with an HVAC Expert . You can always look for and the refrigerant type by reading the nameplate on your condenser ( the condenser is the outside unit ) .
 To be clear , the EPA regulates the production and use of this refrigerant , but not your unit . You are not required by the law to replace your air conditioner . Ultimately , your AC will quit running and it will need to be replaced , and only R410a units will be available for sale .
 The best option is to buy a new , upgraded air conditioner , specifically if your current air conditioner is already more than 10 years old . Service Experts Heating & Air Conditioning has lots of financing options that help to meet your budget , and again , we look out for rebates from HVAC manufacturers and local utilities to make it even easier . New AC equipment will also be more efficient and offer you superior comfort , helping to reduce your energy costs .


text:
How far is 4837 8a Ave from 330 E Columbia St?
Your Travel Plan Starts at 4837 8a Ave, Delta, BC V4M 1S8, Canada.
Want to know the your planned distances for yor journey on a google map? You can see the Distance from 4837 8a Ave to 330 E Columbia St New Westminster!
Want to see your travel plan on the large map? You want to see a bigger Map here- Map from 4837 8a Ave to 330 E Columbia St New Westminster!
You need travel road driving directions to help better plan your travel? Refer the Directions from 4837 8a Ave to 330 E Columbia St New Westminster!
Want to plan your travel by air from 4837 8a Ave to 330 E Columbia St? Check the Flight distance between 4837 8a Ave and 330 E Columbia St New Westminster.
Travel time is very important to execute your tour plan. Plan your trip by getting approximate times here - Travel Time from 4837 8a Ave to 330 E Columbia St New Westminster.
Planning to fly from 4837 8a Ave to 330 E Columbia St? Do want an estimate of the Flight Time from 4837 8a Ave to 330 E Columbia St New Westminster.
Do you want to know what is more, road distance or flight distance? You can find out How far is 330 E Columbia St New Westminster from 4837 8a Ave.
After getting your travel planned, you would also like to get the 4837 8a Ave to 330 E Columbia St New Westminster Route planned with the help of a routeplanner.
After having the entire plan for your journey, you would also like to get an estimate of the travel expenses. You can check the Trip Cost from 4837 8a Ave to 330 E Columbia St New Westminster.

tokenized:
How far is 4837 8a Ave from 330 E Columbia St ?
 Your Travel Plan Starts at 4837 8a Ave , Delta , BC V4 M 1S8 , Canada .
 Want to know the your planned distances for yor journey on a google map ? You can see the Distance from 4837 8a Ave to 330 E Columbia St New Westminster !
 Want to see your travel plan on the large map ? You want to see a bigger Map here- Map from 4837 8a Ave to 330 E Columbia St New Westminster !
 You need travel road driving directions to help better plan your travel ? Refer the Directions from 4837 8a Ave to 330 E Columbia St New Westminster !
 Want to plan your travel by air from 4837 8a Ave to 330 E Columbia St ? Check the Flight distance between 4837 8a Ave and 330 E Columbia St New Westminster .
 Travel time is very important to execute your tour plan . Plan your trip by getting approximate times here - Travel Time from 4837 8a Ave to 330 E Columbia St New Westminster .
 Planning to fly from 4837 8a Ave to 330 E Columbia St ? Do want an estimate of the Flight Time from 4837 8a Ave to 330 E Columbia St New Westminster .
 Do you want to know what is more , road distance or flight distance ? You can find out How far is 330 E Columbia St New Westminster from 4837 8a Ave .
 After getting your travel planned , you would also like to get the 4837 8a Ave to 330 E Columbia St New Westminster Route planned with the help of a routeplanner .
 After having the entire plan for your journey , you would also like to get an estimate of the travel expenses . You can check the Trip Cost from 4837 8a Ave to 330 E Columbia St New Westminster .


text:
Promotes excellence in who the students are and what they know.
Recognize and maximize the individual potential of each student to achieve excellence.
Act in accordance with the institutional values: trustworthiness, respect, responsibility, fairness caring, and citizenship.
Communicate in English and Spanish and promotes bilingualism.
Institute and maintain a classroom environment that promotes student learning.
Uses assessments to support student learning.
Use teaching strategies that are based on research.
Establish and promote appropriate student behavior.
Continuously reflect on their teaching practices.
Recognize and support the school´s governance, follow and respect its norms, and look after the reputation of the School in different scenarios.
Participates in activities which are legally and socially accepted.
Here you may find everything that happens at our school, publish news and check student homework.
This integrated system allows you to check your schedule and publish grades.

tokenized:
Promotes excellence in who the students are and what they know .
 Recognize and maximize the individual potential of each student to achieve excellence .
 Act in accordance with the institutional values : trustworthiness , respect , responsibility , fairness caring , and citizenship .
 Communicate in English and Spanish and promotes bilingualism .
 Institute and maintain a classroom environment that promotes student learning .
 Uses assessments to support student learning .
 Use teaching strategies that are based on research .
 Establish and promote appropriate student behavior .
 Continuously reflect on their teaching practices .
 Recognize and support the school´s governance , follow and respect its norms , and look after the reputation of the School in different scenarios .
 Participates in activities which are legally and socially accepted .
 Here you may find everything that happens at our school , publish news and check student homework .
 This integrated system allows you to check your schedule and publish grades .


text: We are all Newtown…my heart just breaks watching this movie. I’m behind you whatever you need!!

tokenized: We are all Newtown … my heart just breaks watching this movie . I ’m behind you whatever you need ! !


text: By Perceval Leon. Wall Stickers. Published at Monday, April 01st, 2019 - 11:47:15 AM.

tokenized: By Perceval Leon . Wall Stickers . Published at Monday , April 01st , 2019 - 11:47:15 AM .


text:
There is NO embassy/consulate of Vietnam in Puri, India. Travellers from Puri can contact the nearest embassy of Vietnam in New Delhi for visa information.
Indian nationals and foreign visitors living in Puri, India can choose between applying for a visa through the embassy of Vietnam in New Delhi or applying online for an approval letter to pick up the visa on arrival.

tokenized:
There is NO embassy / consulate of Vietnam in Puri , India . Travellers from Puri can contact the nearest embassy of Vietnam in New Delhi for visa information .
 Indian nationals and foreign visitors living in Puri , India can choose between applying for a visa through the embassy of Vietnam in New Delhi or applying online for an approval letter to pick up the visa on arrival .