text:
Outdated, decaying pipes pose a threat to public safety.
An ever-growing backlog of stormwater projects — erosion, failing culverts and blocked inlets — threatens to worsen into expensive, potentially risky emergencies. By making positive changes now, we can stop responding to these issues reactively and become proactive in protecting our river and the health of our community.
such as pipe failures; deteriorated/partially collapsed pipes; sinkholes.
including erosion at outfalls causing pipes to fail; ditch erosion.
including partially blocked inlets and culverts.
Water runs downhill, and we’re fighting an uphill battle. At present, stormwater funding comes primarily from the city’s General Fund or Sewer Fund. Due to budget constraints and ongoing development, we haven’t been able to keep up with the sheer scale of repairs, maintenance and upgrades needed. Stormwater projects keep coming, and we need to tackle them before they get out of hand.
Concrete wall reinforced with rebar is deteriorating along a creek that leads to a culvert. The wall extends a few blocks and is right up against the property lines of houses on either sides of the walls. The wall extends a few blocks and is adjacent to properties on either side.
The two large pipes under the road have started to rust away, which is costly to the integrity of the pipes. The side rails that are protecting the road will be caving in due to soil around the pipes eroding.
The pipe for this outfall is disconnected from the headwall. There is erosion around the headwall, which will lead to the headwall falling further into the creek. The concrete headwall could block the creek in the future if it isn’t addressed.
A long, gently sloping depression or ditch planted with vegetation, bioswales slow and filter water using plants’ roots.
Small but mighty creeks play an important role. Creeks recharge groundwater, reduce erosion and even mitigate damage from floods.
Pipes and culverts convey stormwater throughout Peoria. In fact, Peoria has over 150 miles of storm sewer! Pipes and culverts do wear down over time and must be replaced.
Ponds and lakes slow stormwater runoff, as both can collect and store water. Ponds and Lakes also allow stormwater to be reused.
Often overlooked, curbs and gutters are crucial in the collection and transportation of runoff to storm sewer pipes. Clogged curbs and gutters can lead to street flooding.
Inlets and man holes are building blocks for the storm sewer. Inlets guide water into the pipes. And manholes provide access for inspections, maintenance and more.
A designed, depressed area with native plants, a rain garden can absorb stormwater and add beauty.

lowercased:
outdated, decaying pipes pose a threat to public safety.
an ever-growing backlog of stormwater projects — erosion, failing culverts and blocked inlets — threatens to worsen into expensive, potentially risky emergencies. by making positive changes now, we can stop responding to these issues reactively and become proactive in protecting our river and the health of our community.
such as pipe failures; deteriorated/partially collapsed pipes; sinkholes.
including erosion at outfalls causing pipes to fail; ditch erosion.
including partially blocked inlets and culverts.
water runs downhill, and we’re fighting an uphill battle. at present, stormwater funding comes primarily from the city’s general fund or sewer fund. due to budget constraints and ongoing development, we haven’t been able to keep up with the sheer scale of repairs, maintenance and upgrades needed. stormwater projects keep coming, and we need to tackle them before they get out of hand.
concrete wall reinforced with rebar is deteriorating along a creek that leads to a culvert. the wall extends a few blocks and is right up against the property lines of houses on either sides of the walls. the wall extends a few blocks and is adjacent to properties on either side.
the two large pipes under the road have started to rust away, which is costly to the integrity of the pipes. the side rails that are protecting the road will be caving in due to soil around the pipes eroding.
the pipe for this outfall is disconnected from the headwall. there is erosion around the headwall, which will lead to the headwall falling further into the creek. the concrete headwall could block the creek in the future if it isn’t addressed.
a long, gently sloping depression or ditch planted with vegetation, bioswales slow and filter water using plants’ roots.
small but mighty creeks play an important role. creeks recharge groundwater, reduce erosion and even mitigate damage from floods.
pipes and culverts convey stormwater throughout peoria. in fact, peoria has over 150 miles of storm sewer! pipes and culverts do wear down over time and must be replaced.
ponds and lakes slow stormwater runoff, as both can collect and store water. ponds and lakes also allow stormwater to be reused.
often overlooked, curbs and gutters are crucial in the collection and transportation of runoff to storm sewer pipes. clogged curbs and gutters can lead to street flooding.
inlets and man holes are building blocks for the storm sewer. inlets guide water into the pipes. and manholes provide access for inspections, maintenance and more.
a designed, depressed area with native plants, a rain garden can absorb stormwater and add beauty.


text:
All Armodilo Original tablet enclosures and stands use our patent pending Tablet Fit Kits which nestle the tablet within the enclosure using four precision created corner inserts and a tablet frame. Tablet Fit Kits are swappable for tablets of similar size, allowing you to change tablets for any Original style products.
First set is included with every Original product purchase.
Works with any Original tablet enclosure.
Consists of four corner inserts and a tablet frame.
A choice of home (iOS and Windows) and camera openings on the frames are available.
Swappable for tablets of similar size*.
All our Tablet Fit Kits are produced using our in-house laser cutter and CNC, allowing an unprecedented level of precision for each Tablet Fit Kit. Tablet Fit Kits are available for over 50 different tablets that we carry as standard stock, custom Fit Kits are also available for tablets not listed on our supported tablets page. Learn more about creating a custom Fit Kit for your unique project requirements.

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all armodilo original tablet enclosures and stands use our patent pending tablet fit kits which nestle the tablet within the enclosure using four precision created corner inserts and a tablet frame. tablet fit kits are swappable for tablets of similar size, allowing you to change tablets for any original style products.
first set is included with every original product purchase.
works with any original tablet enclosure.
consists of four corner inserts and a tablet frame.
a choice of home (ios and windows) and camera openings on the frames are available.
swappable for tablets of similar size*.
all our tablet fit kits are produced using our in-house laser cutter and cnc, allowing an unprecedented level of precision for each tablet fit kit. tablet fit kits are available for over 50 different tablets that we carry as standard stock, custom fit kits are also available for tablets not listed on our supported tablets page. learn more about creating a custom fit kit for your unique project requirements.


text:
Fujifilm has introduced the GF 100-200mm F5.6 R LM OIS WR lens, which is the company’s latest super zoom Fujinon lens exclusively for medium format GFX series. When attached to the GFX body, the lens produces a focal length equivalent to 79-158mm on full-frame, in case you need to capture longer distances the lens also has the option of GF1.4X TC WR teleconverter that extends lens’s focal length by 1.4 times, to cover the focal length range of 140mm-280mm (equivalent to 111-221mm in the 35mm film format).
Currently, the Fujifilm GF 100-200mm F5.6 R LM OIS WR lens will be available for global pre-order on Bhphotovideo.com and selling will be starting on February 14th. with a price tag of $1,999.95.
This GF 100-200mm F5.6 lens is also Fujifilm’s first telephoto zoom lens for Medium Format sensors, fully support the 100MP+ image sensor, to be incorporated in the GFX Series’ flagship model is about to launch. This will be a narrow-angle lens so it will be suitable for portraits, landscapes, and nature with a long focusing distance and still give the highest quality of GF lens line.
In terms of design, this lens has an optical structure with 20 elements in 13 groups, in which there are 2 Super ED lens elements and 1 aspherical lens elements, which minimizes chromatic aberration and distortion to help capture images more perfect with high color reproduction. In addition, to ensure high performance for the lens, Fujifilm also equipped with a linear autofocus motor system that enables the camera to focus faster and quieter in combination with a locking mechanism, preventing movement. The need for lenses when the device is inactive increases the life of the lens more than other telephoto lenses. In addition, with the upgrade and change of the position of the linear motor cluster, the lens can keep the focusing position as before when the camera is turned off, making it possible to capture the focus much faster when shooting.
The lens offers a 5.0-stop image stabilization performance, which means you can easily hold and manipulate shots without worrying about blurring. The lens’s weather-sealed construction makes it dust and weather resistant and capable of operating in temperatures down to -10°C, allowing you to shoot even in outdoors in light rain or in dusty conditions, and achieving a high level of reliability as photography equipment for professional photographers.

lowercased:
fujifilm has introduced the gf 100-200mm f5.6 r lm ois wr lens, which is the company’s latest super zoom fujinon lens exclusively for medium format gfx series. when attached to the gfx body, the lens produces a focal length equivalent to 79-158mm on full-frame, in case you need to capture longer distances the lens also has the option of gf1.4x tc wr teleconverter that extends lens’s focal length by 1.4 times, to cover the focal length range of 140mm-280mm (equivalent to 111-221mm in the 35mm film format).
currently, the fujifilm gf 100-200mm f5.6 r lm ois wr lens will be available for global pre-order on bhphotovideo.com and selling will be starting on february 14th. with a price tag of $1,999.95.
this gf 100-200mm f5.6 lens is also fujifilm’s first telephoto zoom lens for medium format sensors, fully support the 100mp+ image sensor, to be incorporated in the gfx series’ flagship model is about to launch. this will be a narrow-angle lens so it will be suitable for portraits, landscapes, and nature with a long focusing distance and still give the highest quality of gf lens line.
in terms of design, this lens has an optical structure with 20 elements in 13 groups, in which there are 2 super ed lens elements and 1 aspherical lens elements, which minimizes chromatic aberration and distortion to help capture images more perfect with high color reproduction. in addition, to ensure high performance for the lens, fujifilm also equipped with a linear autofocus motor system that enables the camera to focus faster and quieter in combination with a locking mechanism, preventing movement. the need for lenses when the device is inactive increases the life of the lens more than other telephoto lenses. in addition, with the upgrade and change of the position of the linear motor cluster, the lens can keep the focusing position as before when the camera is turned off, making it possible to capture the focus much faster when shooting.
the lens offers a 5.0-stop image stabilization performance, which means you can easily hold and manipulate shots without worrying about blurring. the lens’s weather-sealed construction makes it dust and weather resistant and capable of operating in temperatures down to -10°c, allowing you to shoot even in outdoors in light rain or in dusty conditions, and achieving a high level of reliability as photography equipment for professional photographers.


text:
Editor’s note: Laura Bien writes a bi-weekly history column for The Chronicle. This week she describes her experience reenacting the role of an anonymous turn-of-the-century scrubwoman at Ypsilanti’s Heritage Festival, which took place Aug. 20-22.
My rained-on bonnet flopped over my face like a dish towel. I could see only a sliver of sidewalk. What had been a neatly starched head-shield this morning had been ruined by the Saturday rain.
The author made a rag rug in between visitors to Grandma's Trunk.
My long skirt hem was wet, too, and catching on my ankles as I stomped back to the historical museum on Ypsilanti’s Huron Street where our props had been staged overnight. My sleeves were soaked and I was on the verge of tears.
I looked ridiculous. Why, why, had I been so driven to be a historical reenactor at the Ypsilanti Hertitage Festival? Did I even know what I was doing?
Back in the park, the antique trunk I’d borrowed the week before sat under a historically inaccurate blue tarp, waiting for the drizzle to end. I returned from the museum to our staging spot with a basket containing a thermos of water and some bread and cheese concealed under a pillowcase.

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editor’s note: laura bien writes a bi-weekly history column for the chronicle. this week she describes her experience reenacting the role of an anonymous turn-of-the-century scrubwoman at ypsilanti’s heritage festival, which took place aug. 20-22.
my rained-on bonnet flopped over my face like a dish towel. i could see only a sliver of sidewalk. what had been a neatly starched head-shield this morning had been ruined by the saturday rain.
the author made a rag rug in between visitors to grandma's trunk.
my long skirt hem was wet, too, and catching on my ankles as i stomped back to the historical museum on ypsilanti’s huron street where our props had been staged overnight. my sleeves were soaked and i was on the verge of tears.
i looked ridiculous. why, why, had i been so driven to be a historical reenactor at the ypsilanti hertitage festival? did i even know what i was doing?
back in the park, the antique trunk i’d borrowed the week before sat under a historically inaccurate blue tarp, waiting for the drizzle to end. i returned from the museum to our staging spot with a basket containing a thermos of water and some bread and cheese concealed under a pillowcase.


text: Have you been recently promoted or started a new job? Perhaps you are starting on a new educational journey. Or, maybe you are newly married or recently added to your family. Let your fellow Tigers know what is happening with you. Submit a class note for publication in the RIT University Magazine, potential inclusion in the Tiger’s Tale alumni e-newsletter and for posting to RIT alumni website. We want to hear from you!

lowercased: have you been recently promoted or started a new job? perhaps you are starting on a new educational journey. or, maybe you are newly married or recently added to your family. let your fellow tigers know what is happening with you. submit a class note for publication in the rit university magazine, potential inclusion in the tiger’s tale alumni e-newsletter and for posting to rit alumni website. we want to hear from you!


text:
2 hours away from the Tokyo Metropolitan area, the following are access methods to Minano by train or car.
From Kan-etsu Expressway Hanazono Interchange to National Route 140 toward Chichibu.
From Minano Yorii Bypass (Toll), Minano Interchange to National Route 140 "Otsuka"
From Minano Yorii Bypass (Toll), Minano/Nagatoro Interchange to "Minano/Nagatoro Interchange Exit"
Pass through Shomaru Tunnel on National Route 299 and head toward Chichibu. At the intersection of National Route 140 “Uenomachi”, turn right toward Nagatoro.
Take National Route 140 Karisaka Road, take the Karisaka Tunnel (Toll) and head toward Chichibu.
If coming from Ikebukuro Station on the "Seibu Railway"
Take Seibu Ikebukuro or Limited Express Red Arrow (Limited Express fee + regular fare) to Seibu Chichibu. Exit train at Seibu Chichibu.
Walk 3 minutes to Chichibu Railway "Ohanabatake Station" and go in the direction of Hanyu/Kumagaya. Exit at Minano Station.
On JR Kumagaya Station, head in the direction of Chichibu Railway Mitsumineguchi Station and exit at Minano Station.
* For individuals taking the direct train "Chichibu Railway" toward Nagatoro Station from the "Seibu Railway" Ikebukuro Station.
How to IC card fare adjustments using the direct train from Ikebukuro Station to Minano Station.
After doing your fare adjustment at the Minano Station for the difference between Ohanabatake Station and Minano Station, please receive the communication slip so that you can do your fare adjustment on your way back at Seibu-Chichibu Station.
For those using the direct train on their return home, please have a communication slip issued for Ikebukuro Station to do your fare adjustment.
For your Minano and Chichibuji tourist needs, let Chichibu Marutsu Taxi take care of your needs. Feel free to contact us for reservations and any questions you may have.
We have an abundant number of recommended tourism courses, so ask us about them.
We also provide jumbo taxi services, on-demand taxis, and handicap-accessible vehicles. For business or for family and friends, we will assist you on your trip.
The Minano Municipal Bus has two lines: the Hinozawa Line and the Kanezawa Line.
The Chichibu Area Tourism Organization provides services for the Chichibu Wide-Range Tourism Rent-a-cycle "Cycle at Chichibu". The cycle station for "Cycle at Chichibu" rents out bicycles that can returned at any of our stations. Drop off your bicycle at any of our stations when you are finished for a worry-free cycling trip.

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2 hours away from the tokyo metropolitan area, the following are access methods to minano by train or car.
from kan-etsu expressway hanazono interchange to national route 140 toward chichibu.
from minano yorii bypass (toll), minano interchange to national route 140 "otsuka"
from minano yorii bypass (toll), minano/nagatoro interchange to "minano/nagatoro interchange exit"
pass through shomaru tunnel on national route 299 and head toward chichibu. at the intersection of national route 140 “uenomachi”, turn right toward nagatoro.
take national route 140 karisaka road, take the karisaka tunnel (toll) and head toward chichibu.
if coming from ikebukuro station on the "seibu railway"
take seibu ikebukuro or limited express red arrow (limited express fee + regular fare) to seibu chichibu. exit train at seibu chichibu.
walk 3 minutes to chichibu railway "ohanabatake station" and go in the direction of hanyu/kumagaya. exit at minano station.
on jr kumagaya station, head in the direction of chichibu railway mitsumineguchi station and exit at minano station.
* for individuals taking the direct train "chichibu railway" toward nagatoro station from the "seibu railway" ikebukuro station.
how to ic card fare adjustments using the direct train from ikebukuro station to minano station.
after doing your fare adjustment at the minano station for the difference between ohanabatake station and minano station, please receive the communication slip so that you can do your fare adjustment on your way back at seibu-chichibu station.
for those using the direct train on their return home, please have a communication slip issued for ikebukuro station to do your fare adjustment.
for your minano and chichibuji tourist needs, let chichibu marutsu taxi take care of your needs. feel free to contact us for reservations and any questions you may have.
we have an abundant number of recommended tourism courses, so ask us about them.
we also provide jumbo taxi services, on-demand taxis, and handicap-accessible vehicles. for business or for family and friends, we will assist you on your trip.
the minano municipal bus has two lines: the hinozawa line and the kanezawa line.
the chichibu area tourism organization provides services for the chichibu wide-range tourism rent-a-cycle "cycle at chichibu". the cycle station for "cycle at chichibu" rents out bicycles that can returned at any of our stations. drop off your bicycle at any of our stations when you are finished for a worry-free cycling trip.


text:
You might have lingered in the glamorous shopping malls, marveled at the aesthetics of Dubai’s skyline from the observation deck at the Burj Khalifa, befriended dolphins at the Atlantis, enjoyed pampering spa sessions at the nicest hotels in Dubai, partied with the city’s fashionable crowd and even had your fair share of market hopping in the old neighborhoods of Deira, but Dubai’s still got a lot more up its sleeve to surprise you.
If you thought that you could cram a visit to the city in a stopover, then make no mistake–you will be missing the chance to enjoy the great outdoors. These day trips from Dubai present to you an interesting mix of nature, wildlife and heritage and are not to be missed if you want to peel back the layers a little and travel deeper.
At 1,240 meters above sea level, Jabeel Hafeet, 140 kms away from Dubai, is not only the U.A.E’s second highest peak, it’s also one of the most scenic routes in the country. Located in the garden city of Al Ain, the road trip is very popular with local residents looking to escape the buzz of the city on weekends, especially in the cooler months. At the top, enjoy the magnificent views of Al Ain and Oman. On your way back, stop at Green Mubazzarah at the base of the mountain to dip your toes in the hot water springs that are believed to be therapeutic.
A one and a half hour drive from Dubai, the emirate of Ras Al Khaimah is a popular day trip for residents and tourists, providing a pleasant change from Dubai’s urban cityscape with its raw and rugged landscape. You can even go on a safari to explore the desert. If you are more of a history buff, you will love to explore the 16th century Dhayah Fort and the mid-18th century National Museum of Ras Al Khaimah that served as the former residence of the ruling Al Qawasim family. Don’t forget the ghost town of Jazirat Al Hamra, one of the country’s oldest historical sites, a traditional fishing town that was abandoned by its residents around 40 years ago. Noteworthy is the coral stone architecture and the features of the township such as a fortress, school, market, houses, wind towers, mosques and courtyards.
While in RAK, you can also visit the relaxing Khatt Hot Springs and spend some time in the mineral pools at the base of the scenic Hajar Mountains. Locals believe the springs have therapeutic qualities and you can ever book some time in a private pool.
A one hour drive away from Dubai, Dibba on the east coast of the Musandam Peninsula makes for an ideal getaway. Nestled in the picturesque mountainous landscape of Oman, with its towering cliffs and fjords, Dibba is best and most conveniently experienced by a Dhow Cruise in a traditional boat.
Active travelers will enjoy swimming, snorkeling, diving and kayaking in the pristine Arabian waters. You’re also likely to see dolphins and rich marine life. The town itself is very simple and the pace of life is slow as is usually the case outside cities. All visitors must bring their passports as you will be crossing into Omani territory.
Stay tuned for Part 2 of this series with other cool day trips from Dubai.
If you’re visiting Dubai on a budget, check out my tips for traveling in Dubai on the cheap.
For general information to help you plan your trip to the UAE or Dubai in particular and recommendations for culture in Abu Dhabi, cool hotels, or popular places of interest such as the Dubai Miracle Garden and At The Top Burj Khalifa, check out my UAE Travel Blog.

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you might have lingered in the glamorous shopping malls, marveled at the aesthetics of dubai’s skyline from the observation deck at the burj khalifa, befriended dolphins at the atlantis, enjoyed pampering spa sessions at the nicest hotels in dubai, partied with the city’s fashionable crowd and even had your fair share of market hopping in the old neighborhoods of deira, but dubai’s still got a lot more up its sleeve to surprise you.
if you thought that you could cram a visit to the city in a stopover, then make no mistake–you will be missing the chance to enjoy the great outdoors. these day trips from dubai present to you an interesting mix of nature, wildlife and heritage and are not to be missed if you want to peel back the layers a little and travel deeper.
at 1,240 meters above sea level, jabeel hafeet, 140 kms away from dubai, is not only the u.a.e’s second highest peak, it’s also one of the most scenic routes in the country. located in the garden city of al ain, the road trip is very popular with local residents looking to escape the buzz of the city on weekends, especially in the cooler months. at the top, enjoy the magnificent views of al ain and oman. on your way back, stop at green mubazzarah at the base of the mountain to dip your toes in the hot water springs that are believed to be therapeutic.
a one and a half hour drive from dubai, the emirate of ras al khaimah is a popular day trip for residents and tourists, providing a pleasant change from dubai’s urban cityscape with its raw and rugged landscape. you can even go on a safari to explore the desert. if you are more of a history buff, you will love to explore the 16th century dhayah fort and the mid-18th century national museum of ras al khaimah that served as the former residence of the ruling al qawasim family. don’t forget the ghost town of jazirat al hamra, one of the country’s oldest historical sites, a traditional fishing town that was abandoned by its residents around 40 years ago. noteworthy is the coral stone architecture and the features of the township such as a fortress, school, market, houses, wind towers, mosques and courtyards.
while in rak, you can also visit the relaxing khatt hot springs and spend some time in the mineral pools at the base of the scenic hajar mountains. locals believe the springs have therapeutic qualities and you can ever book some time in a private pool.
a one hour drive away from dubai, dibba on the east coast of the musandam peninsula makes for an ideal getaway. nestled in the picturesque mountainous landscape of oman, with its towering cliffs and fjords, dibba is best and most conveniently experienced by a dhow cruise in a traditional boat.
active travelers will enjoy swimming, snorkeling, diving and kayaking in the pristine arabian waters. you’re also likely to see dolphins and rich marine life. the town itself is very simple and the pace of life is slow as is usually the case outside cities. all visitors must bring their passports as you will be crossing into omani territory.
stay tuned for part 2 of this series with other cool day trips from dubai.
if you’re visiting dubai on a budget, check out my tips for traveling in dubai on the cheap.
for general information to help you plan your trip to the uae or dubai in particular and recommendations for culture in abu dhabi, cool hotels, or popular places of interest such as the dubai miracle garden and at the top burj khalifa, check out my uae travel blog.


text:
Celebrate Small Business Saturday every day by shopping local from one of the many makers in Pittsburgh. We rounded up a few of our favorite Pittsburgh-made items and organized the list by price, so you can scroll from stocking stuffers to big-ticket gifts.
Need some more inspiration? Check out our 2017 Pittsburgh gift guide or stop by one of the many holiday markets around town to find even more local gifts.
Jimminy Christmas, these yinzer greeting cards are adorable. Four new cards are available for the holidays from Yinzer Cards, including a classic PennDOT jab: “Rudolph with yer nose so bright … won’t yinz help me close dahn the Liberty Tubes tonight?” The cards are the work of cartoonist Rob Robers with radio personalities Jim Krenn and Larry Richert. Cards are available online or at Giant Eagle (because of course). A portion proceeds benefits Animal Friends.
Milk, cookies, and a parking space.
Yes, you read that right. Slovakian cabbage soap. This soap by Regent Park Naturals combines the anti-inflammatory properties of cabbage juice — from local cabbage — with the skin conditioning abilities of green bentonite clay. The soap celebrates the hard work of Pittsburgh’s immigrant ancestors.
Mmm ... smells like cabbage.
Designed for kids of all ages, My Place in the World follows the adventures of Atlee as “she marches in her yellow boots to the tallest mountains, deepest seas, and even the White House to discover her place in the world.” The new book is the work of illustrator Liz Beatty and Aryanna Berringer, an Iraq war veteran who recently ran for lieutenant governor. A portion of the proceeds supports The Women & Girls Foundation.
Inspiration from "My Place in the World."
Give the gift of a good night’s sleep with the Counting Sheep Sleep Mask from monamona, where products are made using primarily secondhand materials. “mọnamọna is a brand that aims to provide radical femmes with one-of-a-kind statement pieces they can feel good about,” per the brand’s website.
These made-in-Pittsburgh prints will brighten up any room with their vibrant colors and sense of whimsy. Check out the Underwater Bug-a-Zoo series offered in a variety of print sizes. Jarrod Edson, of Autism Draws, starts drawing each work with paper and pencil, then scans, digitizes and colorizes the works. The 19-year-old artist is a Who’s Next honoree (learn more about him here) who shares his profits with two organizations that have had a strong influence in his life: The Children’s Institute and The Friendship Circle.
From the Underwater Bug-a-Zoo collection.
For the literary lover in your life, offer a gift to inspire them to write. The covers of these journals feature excerpts from Shakespeare’s best-loved plays, and inside there’s plenty of space for note-taking, journaling, and list-making. You can pick your favorite play and favorite color for the book. Cannibal Paper Goods, a local bookbindery, specializes in turning old and abandoned books into new keepsakes, such as sketchbooks, guestbooks, and even jewelry.
Journal, journal, wherefore art thou, journal?
Remember the booze-filled pourable Hennessy nails that went viral this year? The artist, Le’Chele Barnett, is a Pittsburgher, and while she won’t do that exact style on your fingertips, she’ll certainly polish your nails to perfection. Barnett, a Who’s Next honoree, works at Ambiance Hair & Nail Gallery on the North Side where spa manicures start at $25. Treat yourself (or somebody else) to some pampering.
Wake up each morning to a cup of coffee in these festive blue-and-white mugs from local artist Reiko Yamamoto who makes versatile and functional pottery for everyday use. Buy one or mix and match designs to make a set. Each mug holds about 10 ounces of liquid, so pair this gift with a bag of coffee from La Prima or some tea from Allegheny Coffee & Tea Exchange.
Up your morning coffee game.
These tie-dye throw pillows from I Would Dye For You are equal parts fine art and casual home decor. Dyed in khaki and black they’ll match just about any color palette. Grab one or two, and you can even pick up a blanket to go with it.
Sure, jewelry is always nice, but when it’s imbued with meaning, it’s truly a cherished keepsake. Described as “purposeful jewelry to inspire mindfulness and magic,” these ornate pieces from Lady Halls Beads do more than just look pretty.
There’s nothing better than giving someone a happy memory. Try an experience gift this year — think tickets to an Arcade Comedy show, a season pass for the Schenley Plaza carousel, or a visit to Phipps Conservatory. With so many museums and cultural attractions in town, the possibilities are practically endless, whether you’re shopping for your Grandma, your nephew, or your friend. Remember to take some pictures, and those memories will carry you through 2019.

lowercased:
celebrate small business saturday every day by shopping local from one of the many makers in pittsburgh. we rounded up a few of our favorite pittsburgh-made items and organized the list by price, so you can scroll from stocking stuffers to big-ticket gifts.
need some more inspiration? check out our 2017 pittsburgh gift guide or stop by one of the many holiday markets around town to find even more local gifts.
jimminy christmas, these yinzer greeting cards are adorable. four new cards are available for the holidays from yinzer cards, including a classic penndot jab: “rudolph with yer nose so bright … won’t yinz help me close dahn the liberty tubes tonight?” the cards are the work of cartoonist rob robers with radio personalities jim krenn and larry richert. cards are available online or at giant eagle (because of course). a portion proceeds benefits animal friends.
milk, cookies, and a parking space.
yes, you read that right. slovakian cabbage soap. this soap by regent park naturals combines the anti-inflammatory properties of cabbage juice — from local cabbage — with the skin conditioning abilities of green bentonite clay. the soap celebrates the hard work of pittsburgh’s immigrant ancestors.
mmm ... smells like cabbage.
designed for kids of all ages, my place in the world follows the adventures of atlee as “she marches in her yellow boots to the tallest mountains, deepest seas, and even the white house to discover her place in the world.” the new book is the work of illustrator liz beatty and aryanna berringer, an iraq war veteran who recently ran for lieutenant governor. a portion of the proceeds supports the women & girls foundation.
inspiration from "my place in the world."
give the gift of a good night’s sleep with the counting sheep sleep mask from monamona, where products are made using primarily secondhand materials. “mọnamọna is a brand that aims to provide radical femmes with one-of-a-kind statement pieces they can feel good about,” per the brand’s website.
these made-in-pittsburgh prints will brighten up any room with their vibrant colors and sense of whimsy. check out the underwater bug-a-zoo series offered in a variety of print sizes. jarrod edson, of autism draws, starts drawing each work with paper and pencil, then scans, digitizes and colorizes the works. the 19-year-old artist is a who’s next honoree (learn more about him here) who shares his profits with two organizations that have had a strong influence in his life: the children’s institute and the friendship circle.
from the underwater bug-a-zoo collection.
for the literary lover in your life, offer a gift to inspire them to write. the covers of these journals feature excerpts from shakespeare’s best-loved plays, and inside there’s plenty of space for note-taking, journaling, and list-making. you can pick your favorite play and favorite color for the book. cannibal paper goods, a local bookbindery, specializes in turning old and abandoned books into new keepsakes, such as sketchbooks, guestbooks, and even jewelry.
journal, journal, wherefore art thou, journal?
remember the booze-filled pourable hennessy nails that went viral this year? the artist, le’chele barnett, is a pittsburgher, and while she won’t do that exact style on your fingertips, she’ll certainly polish your nails to perfection. barnett, a who’s next honoree, works at ambiance hair & nail gallery on the north side where spa manicures start at $25. treat yourself (or somebody else) to some pampering.
wake up each morning to a cup of coffee in these festive blue-and-white mugs from local artist reiko yamamoto who makes versatile and functional pottery for everyday use. buy one or mix and match designs to make a set. each mug holds about 10 ounces of liquid, so pair this gift with a bag of coffee from la prima or some tea from allegheny coffee & tea exchange.
up your morning coffee game.
these tie-dye throw pillows from i would dye for you are equal parts fine art and casual home decor. dyed in khaki and black they’ll match just about any color palette. grab one or two, and you can even pick up a blanket to go with it.
sure, jewelry is always nice, but when it’s imbued with meaning, it’s truly a cherished keepsake. described as “purposeful jewelry to inspire mindfulness and magic,” these ornate pieces from lady halls beads do more than just look pretty.
there’s nothing better than giving someone a happy memory. try an experience gift this year — think tickets to an arcade comedy show, a season pass for the schenley plaza carousel, or a visit to phipps conservatory. with so many museums and cultural attractions in town, the possibilities are practically endless, whether you’re shopping for your grandma, your nephew, or your friend. remember to take some pictures, and those memories will carry you through 2019.


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You're able to count on Windowless Air Conditioner Guys to deliver the top products and services regarding Windowless Air Conditioners in Colton, OR. We have a staff of professional experts and the most resourceful technologies available to supply just what you want. We make sure you receive the highest quality solutions, the ultimate selling price, and the very best quality products. Contact us at 888-291-6556 and we'll be able to consider the options, resolve your questions, and arrange a scheduled appointment to get started scheduling the project.
Here at Windowless Air Conditioner Guys, we understand that you'll want to remain in your financial budget and spend less money everywhere it's possible to. Still, lowering costs should not suggest that you compromise on superior quality for Windowless Air Conditioners in Colton, OR. Our initiatives to save a little money are not going to eliminate the quality of our results. We make use of the finest techniques and products to be certain that your work is going to hold up against the test of time, and save a little money with solutions that don't affect the excellent quality of the mission. It will be feasible given that we recognize how to save time and cash on products and work. Choose Windowless Air Conditioner Guys when you need the most impressive services at a minimal cost. Call 888-291-6556 to talk to our customer service representatives, today.
On the subject of Windowless Air Conditioners in Colton, OR, you have to be well informed to come up with the most effective judgments. We will never inspire you to come up with ill advised decisions, as we know exactly what we'll be working at, and we make sure you know exactly what to be expecting with the work. You will not deal with any surprises whenever you work with Windowless Air Conditioner Guys. Start off by dialing 888-291-6556 to talk about your venture. We are going to address all your questions and concerns and arrange the first appointment. Our company can show up at the scheduled time with all the needed resources, and will work with you all through the process.
When you find yourself preparing a project regarding Windowless Air Conditioners in Colton, OR, you will find good reasons to prefer Windowless Air Conditioner Guys. Our products are of the highest quality, our money saving practices are functional and efficient, and our customer satisfaction ratings are unrivaled. Our company is there to assist you with the most experience and competence in the market. Call 888-291-6556 when you need Windowless Air Conditioners in Colton, and we will work with you to properly carry out the project.

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you're able to count on windowless air conditioner guys to deliver the top products and services regarding windowless air conditioners in colton, or. we have a staff of professional experts and the most resourceful technologies available to supply just what you want. we make sure you receive the highest quality solutions, the ultimate selling price, and the very best quality products. contact us at 888-291-6556 and we'll be able to consider the options, resolve your questions, and arrange a scheduled appointment to get started scheduling the project.
here at windowless air conditioner guys, we understand that you'll want to remain in your financial budget and spend less money everywhere it's possible to. still, lowering costs should not suggest that you compromise on superior quality for windowless air conditioners in colton, or. our initiatives to save a little money are not going to eliminate the quality of our results. we make use of the finest techniques and products to be certain that your work is going to hold up against the test of time, and save a little money with solutions that don't affect the excellent quality of the mission. it will be feasible given that we recognize how to save time and cash on products and work. choose windowless air conditioner guys when you need the most impressive services at a minimal cost. call 888-291-6556 to talk to our customer service representatives, today.
on the subject of windowless air conditioners in colton, or, you have to be well informed to come up with the most effective judgments. we will never inspire you to come up with ill advised decisions, as we know exactly what we'll be working at, and we make sure you know exactly what to be expecting with the work. you will not deal with any surprises whenever you work with windowless air conditioner guys. start off by dialing 888-291-6556 to talk about your venture. we are going to address all your questions and concerns and arrange the first appointment. our company can show up at the scheduled time with all the needed resources, and will work with you all through the process.
when you find yourself preparing a project regarding windowless air conditioners in colton, or, you will find good reasons to prefer windowless air conditioner guys. our products are of the highest quality, our money saving practices are functional and efficient, and our customer satisfaction ratings are unrivaled. our company is there to assist you with the most experience and competence in the market. call 888-291-6556 when you need windowless air conditioners in colton, and we will work with you to properly carry out the project.


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Discussion in 'Web & Email' started by jimjpell, Jan 31, 2005.
Everytime I open IE my text size opens as "Medium". I set it back to "Smaller" but next time I open it it comes back as "Medium".
Internet Options > Programs tab?
If the above does not work, try the following.
When you reset your text settings, do you have other browsers open?
If so, try this, open only one instance of Internet Explorer, reset your text size, close the browser.
Windows should remember the settings for the last window you closed.
Reopen Internet Explorer to see if your settings have been retained.
It seems your 2nd suggestion has worked. Usually have multiple instances of IE open. That was an easy one. I feel a little silly. Thank you.

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discussion in 'web & email' started by jimjpell, jan 31, 2005.
everytime i open ie my text size opens as "medium". i set it back to "smaller" but next time i open it it comes back as "medium".
internet options > programs tab?
if the above does not work, try the following.
when you reset your text settings, do you have other browsers open?
if so, try this, open only one instance of internet explorer, reset your text size, close the browser.
windows should remember the settings for the last window you closed.
reopen internet explorer to see if your settings have been retained.
it seems your 2nd suggestion has worked. usually have multiple instances of ie open. that was an easy one. i feel a little silly. thank you.


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To begin our new design and technology topic, Team 4 visited the Royal Albert Hall to watch the fantastic Cirque du Soleil perform!
They all absolutely loved the experience, with some saying it was the best school trip they had ever been on!
During this term, Team 4 will be working with engineers from Rolls Royce to create models of the stage, learning more about different mechanisms and how they work.

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to begin our new design and technology topic, team 4 visited the royal albert hall to watch the fantastic cirque du soleil perform!
they all absolutely loved the experience, with some saying it was the best school trip they had ever been on!
during this term, team 4 will be working with engineers from rolls royce to create models of the stage, learning more about different mechanisms and how they work.


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Infysolutions provides you best software development services at cost-effective rates so look no further contact for a range of e-solutions that meet your business needs.
This handy portal is your resource for learning basic Web design fast.
Best Design Services assist you in developing Logos which portray what business you are in. Our logo design services include Custom Logo Design, Business Logo Design, Flash Logo Design and Text logo design.
SoCal WebWorx is a custom website design and development company. Services include creative website design, template website customization, Flash animation, eCommerce and Search Engine Optimization.
Redline Company are a leading marketing company based in Marbella and offer high quality web design services specialising in Joomla and Wordpress development.
Logo Design by Logoratory, doing an excellent job capturing the essence of a business in superb, clean logo designs.
If you need the services of a graphic designer melbourne area, ABC Web Designs can help.
WebInfo Technologies is a Professional Website Company in Jalandhar. We deal with Web Designing , Web Development , Search Engine Optimization , CMS Websites , PHP & SEO training in Jalandhar. We provide extra features like Grafic Design,3d Design,Static and Dynamic Design,Responsive Website Design,Mobile Apps and Software to user.
NOVA MedMarket is a full service Dental and Medical Marketing firm which offers doctors and dentist the best solutions for their Website Design, Online advertising, SEO, social media and more.
Capanicus is expertise in web application development utilizing advanced technologies for developing responsive ecommerce websites and CMS websites efficiently.
Cartystudios specialize in creating beautiful websites that convert visitors into leads for your business. Cartystudios websites are responsive to fit all devices from desktop to mobiles or tablets.

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infysolutions provides you best software development services at cost-effective rates so look no further contact for a range of e-solutions that meet your business needs.
this handy portal is your resource for learning basic web design fast.
best design services assist you in developing logos which portray what business you are in. our logo design services include custom logo design, business logo design, flash logo design and text logo design.
socal webworx is a custom website design and development company. services include creative website design, template website customization, flash animation, ecommerce and search engine optimization.
redline company are a leading marketing company based in marbella and offer high quality web design services specialising in joomla and wordpress development.
logo design by logoratory, doing an excellent job capturing the essence of a business in superb, clean logo designs.
if you need the services of a graphic designer melbourne area, abc web designs can help.
webinfo technologies is a professional website company in jalandhar. we deal with web designing , web development , search engine optimization , cms websites , php & seo training in jalandhar. we provide extra features like grafic design,3d design,static and dynamic design,responsive website design,mobile apps and software to user.
nova medmarket is a full service dental and medical marketing firm which offers doctors and dentist the best solutions for their website design, online advertising, seo, social media and more.
capanicus is expertise in web application development utilizing advanced technologies for developing responsive ecommerce websites and cms websites efficiently.
cartystudios specialize in creating beautiful websites that convert visitors into leads for your business. cartystudios websites are responsive to fit all devices from desktop to mobiles or tablets.


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micro sediment grinding machine. chilli cutting machine, bridge cutting and grinding machinekty1 350m. Read More. emery mill stone sand and powder.
micro sediment grinding machine. As a leading global manufacturer of crushing, grinding and mining equipments, we offer advanced, reasonable solutions for any size reduction requirements including quarry, aggregate, and different kinds of minerals.
Grinding mill machine, operation, working principle, parameter norton grinding machinery old; sediment grinding machine; micro soil grinding machine in dubai.
As a result, the grinding machine can expect to experience improved feed rates, longer diamond tooling life as well as showing improved glass edge quality.
sop machine grinding, how to do end mill grinding Grinding Procedure for Sediment or Soil Samples Grinding Procedure for Sediment or Soil Samples .
grinding of ore in ball mill; grinding machines black and decker uk; Grinding Mill, ball grinder for crushing sediment amp others sample.
The Inline Water Filters Washing Machine Water Filter Sediment Screen can be used with the following washing machines:. All washing machines; A problem area on all washing machines is the need to clean the inlet valve screen containing sediment build up.
Diatomite Grinding Machine and Processing Line. Diatomite is a kind of biogenic siliceous sediment, which is mainly composed of the ancient remains of diatoms.
Standard Operating Procedure: Saw Cutting, Grinding, and Drilling Sediment Control. Concrete Grinding Machines (Recommended) Order Today For Delivery Tomorrow.
Residue cleaning machine is suitable for peppers, ginger, garlic, carrots, jujube, taro and other round, cylindrical and irregular shape of vegetables and fruits. We are offering Residue cleaning machine to our clients.
All of these facilities are available in the clay mineralogy laboratory along with high–speed grinding and crushing equipment. The lab is located adjacent to the XRD and XRF laboratories for easy access to those analytical facilities.

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micro sediment grinding machine. chilli cutting machine, bridge cutting and grinding machinekty1 350m. read more. emery mill stone sand and powder.
micro sediment grinding machine. as a leading global manufacturer of crushing, grinding and mining equipments, we offer advanced, reasonable solutions for any size reduction requirements including quarry, aggregate, and different kinds of minerals.
grinding mill machine, operation, working principle, parameter norton grinding machinery old; sediment grinding machine; micro soil grinding machine in dubai.
as a result, the grinding machine can expect to experience improved feed rates, longer diamond tooling life as well as showing improved glass edge quality.
sop machine grinding, how to do end mill grinding grinding procedure for sediment or soil samples grinding procedure for sediment or soil samples .
grinding of ore in ball mill; grinding machines black and decker uk; grinding mill, ball grinder for crushing sediment amp others sample.
the inline water filters washing machine water filter sediment screen can be used with the following washing machines:. all washing machines; a problem area on all washing machines is the need to clean the inlet valve screen containing sediment build up.
diatomite grinding machine and processing line. diatomite is a kind of biogenic siliceous sediment, which is mainly composed of the ancient remains of diatoms.
standard operating procedure: saw cutting, grinding, and drilling sediment control. concrete grinding machines (recommended) order today for delivery tomorrow.
residue cleaning machine is suitable for peppers, ginger, garlic, carrots, jujube, taro and other round, cylindrical and irregular shape of vegetables and fruits. we are offering residue cleaning machine to our clients.
all of these facilities are available in the clay mineralogy laboratory along with high–speed grinding and crushing equipment. the lab is located adjacent to the xrd and xrf laboratories for easy access to those analytical facilities.


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The area you are entering is for members only.
The GameCareerGuide.com school directory is integrated with Gamasutra's login system. Please login below with your Gamasutra information, or if you are not a member, join today -- it's free!
Existing Gamasutra users must set a password before logging in for the first time.
Note that your browser must support Cookies in order to login to Gamasutra.

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the area you are entering is for members only.
the gamecareerguide.com school directory is integrated with gamasutra's login system. please login below with your gamasutra information, or if you are not a member, join today -- it's free!
existing gamasutra users must set a password before logging in for the first time.
note that your browser must support cookies in order to login to gamasutra.


text:
will help bring in new shooters to this great sport, young and old.
Ghost Targets are bio-degradable, non-flammable, non-toxic and completely safe to handle for shooters of any age.
If You can HIT a Ghost....You can HIT anything!!!
Copyright © 2013. All rights reserved. Reproduction strictly prohibited.

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will help bring in new shooters to this great sport, young and old.
ghost targets are bio-degradable, non-flammable, non-toxic and completely safe to handle for shooters of any age.
if you can hit a ghost....you can hit anything!!!
copyright © 2013. all rights reserved. reproduction strictly prohibited.


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If you would like to work together, or just have a question or comment, let Jake know by typing out an email down below! Alternatively, you could also just chant the magic spell "magalooga poshinpoomp expudunda babookerfff Jake! Jake!! Jake!!!" to summon him, but lets face it, that's impracticle.
Find me on social media, use the form below, or hit me up via email at grumpinpumpkin@gmail.com.

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if you would like to work together, or just have a question or comment, let jake know by typing out an email down below! alternatively, you could also just chant the magic spell "magalooga poshinpoomp expudunda babookerfff jake! jake!! jake!!!" to summon him, but lets face it, that's impracticle.
find me on social media, use the form below, or hit me up via email at grumpinpumpkin@gmail.com.


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The problem many CBD vapers have faced recently seems to stem mainly from poor regulation over the vaping market in general, and the. Vaping CBD can offer almost immediate relief to symptoms ranging from chronic pain to anxiety. However, getting started can be intimidated. While CBD oil tinctures and gel caps remain popular delivery methods for many CBD consumers, another method of consumption is on the rise: vaporizing. A vaporizer uses much lower temperatures than those used when smoking to convert a liquid (oil-based) CBD extract into a vapor.
There are batteries that have three settings on it and perhaps trying the lower setting. Dabs and any of that stuff does KILL my throat. I think maybe you are just vaping too hot. Honestly, in 10 or so years we will probably find out that vapes and vape pens are way worse for us than any cigarette or tobacco could ever be. Does anyone know if I can use my cool fire 4 with a new tank to vape CBD oil? I can adjust the volts to a safe number.. We advise investing in a top-quality mod that has a temperature range you can trust.
There is no reason for vape pens or other mods to be operating at temps higher than about deg F. Leave a Reply Cancel reply.
Your email address will not be published. Remember me Lost your password? What Can You Do? Maxman on February 9, Robyn on December 4, Robin on January 4, Devin on November 26, Shane on November 26, Dylan on November 26, Robin Bunker on July 11, James on July 9, James on July 23, Janis on June 24, Leave a Reply Cancel reply Your email address will not be published. What Does Weed Do to You?
How cannabis affects your body and mind. CBD is also an integral part of the human body, since we also produce our own Cannabinoids.
The CBD produced by cannabis phytocannabinoids mimics very well the CBD in human physiology, which is why it works so well as medicine for us. Over time, this led to the discovery of a physiological system of tremendous importance in humans: The Endocannabinoid System, rightly named after the plant. CBD is so important for us that pharma companies manufacture synthetic marijuana drugs. Read about it here.
Good thing Marijuana is slowly being decriminalized around the world, liberating us little by little from corporate pharma. Epilepsy CBD Can help patients whose seizures had been non-responsive to prior treatments. Sleep Taking CBD before bed can improve sleep in those with insomnia. Skin CBD can treat psoriasis as it reduces the growth of skin cells. Acne CBD has an anti-inflammatory effect on sebaceous glands. Chronic Pain CDB can replace the use of opioids without the unwanted side effects.
Rheumatoid Arthriti s CBD can protect joints against severe damage, pain and swelling. Recovering Alcoholics CBD could be used as a potential treatment for alcoholic liver diseases.
CBD Vape Oil is the preferred method of consuming CBD oil, according to purists and scientific studies alike. Vaping CBD increases the. The Pros and Cons of Vaping CBD Oil. August 31, 7 min read. hemp- cannabis-leaves-stems. You may have heard about CBD. Whether it is mentioned on. If you have any sort of chronic health condition, mental or physical, chances are that someone has mentioned cannabis as treatment.
CBD Vape Oil is the preferred method of consuming CBD oil, according to purists and scientific studies alike. Vaping CBD increases the.
The Pros and Cons of Vaping CBD Oil. August 31, 7 min read. hemp- cannabis-leaves-stems. You may have heard about CBD. Whether it is mentioned on.
Why Should Cannabidiol CBD Oil Supplements Be Applied In Dunnigan Yolo, CA?

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the problem many cbd vapers have faced recently seems to stem mainly from poor regulation over the vaping market in general, and the. vaping cbd can offer almost immediate relief to symptoms ranging from chronic pain to anxiety. however, getting started can be intimidated. while cbd oil tinctures and gel caps remain popular delivery methods for many cbd consumers, another method of consumption is on the rise: vaporizing. a vaporizer uses much lower temperatures than those used when smoking to convert a liquid (oil-based) cbd extract into a vapor.
there are batteries that have three settings on it and perhaps trying the lower setting. dabs and any of that stuff does kill my throat. i think maybe you are just vaping too hot. honestly, in 10 or so years we will probably find out that vapes and vape pens are way worse for us than any cigarette or tobacco could ever be. does anyone know if i can use my cool fire 4 with a new tank to vape cbd oil? i can adjust the volts to a safe number.. we advise investing in a top-quality mod that has a temperature range you can trust.
there is no reason for vape pens or other mods to be operating at temps higher than about deg f. leave a reply cancel reply.
your email address will not be published. remember me lost your password? what can you do? maxman on february 9, robyn on december 4, robin on january 4, devin on november 26, shane on november 26, dylan on november 26, robin bunker on july 11, james on july 9, james on july 23, janis on june 24, leave a reply cancel reply your email address will not be published. what does weed do to you?
how cannabis affects your body and mind. cbd is also an integral part of the human body, since we also produce our own cannabinoids.
the cbd produced by cannabis phytocannabinoids mimics very well the cbd in human physiology, which is why it works so well as medicine for us. over time, this led to the discovery of a physiological system of tremendous importance in humans: the endocannabinoid system, rightly named after the plant. cbd is so important for us that pharma companies manufacture synthetic marijuana drugs. read about it here.
good thing marijuana is slowly being decriminalized around the world, liberating us little by little from corporate pharma. epilepsy cbd can help patients whose seizures had been non-responsive to prior treatments. sleep taking cbd before bed can improve sleep in those with insomnia. skin cbd can treat psoriasis as it reduces the growth of skin cells. acne cbd has an anti-inflammatory effect on sebaceous glands. chronic pain cdb can replace the use of opioids without the unwanted side effects.
rheumatoid arthriti s cbd can protect joints against severe damage, pain and swelling. recovering alcoholics cbd could be used as a potential treatment for alcoholic liver diseases.
cbd vape oil is the preferred method of consuming cbd oil, according to purists and scientific studies alike. vaping cbd increases the. the pros and cons of vaping cbd oil. august 31, 7 min read. hemp- cannabis-leaves-stems. you may have heard about cbd. whether it is mentioned on. if you have any sort of chronic health condition, mental or physical, chances are that someone has mentioned cannabis as treatment.
cbd vape oil is the preferred method of consuming cbd oil, according to purists and scientific studies alike. vaping cbd increases the.
the pros and cons of vaping cbd oil. august 31, 7 min read. hemp- cannabis-leaves-stems. you may have heard about cbd. whether it is mentioned on.
why should cannabidiol cbd oil supplements be applied in dunnigan yolo, ca?


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Autocare of Solihull operate a fully mobile vehicle valeting and detailing service throughout the West Midlands, Warwickshire and further afield.
Paintwork Protection - Why So Important?
Winter time can really be tough on your car exterior. Paintwork and wheels suffer an increase in road grime and, with the cold weather washing can become less frequent. Click on images to enlarge them.
Before winter sets in its time to apply some long lasting protection so your car is easier to wash and there is less chance of dirt gripping your paintwork and wheels.
Autocare wash the exterior body work using our multi wash system, rinsing then treating the bodywork with biodegradeable grime remover. Rinsing again them washing the entire car with a ph neutral shampoo, lambs wool wash mitt and the two bucket method (buckets with grit guard to avoid dragging any minute grit particles around your car causing swirl marks).
Rinsing and drying follows then the wheels are cleaned with a non acid wheel cleaner to remove brake dust and dirt. Then rinse and dry with micro fiber towels.
Paintwork is then treated to remove any contamination, tree sap, tar spots and industrial fall out. The cleaner and smoother the surface of paintwork and wheels enables the sealants to perform to there best.
Next we cleanse the paintwork and wheels to ensure the surface is ready to receive the sealant. Sealants are chosen for this particular valet to seal the surface from the harsh environment. Sealants are synthetic waxes formulated for long lasting protective qualities and do not contain any abrasives. They are applied by hand then buffed.
Alloy wheels are treated the same but with a dedicated alloy wheel sealant.
Keeping your car paint finish looking good for longer.
Do water droplets bead on your car paintwork?
Applying a layer of wax to your car paintwork finish creates a barrier keeping dirt, grime and other contaminants from reaching the paint finish of your car and starting a process of deterioration. Real waxes contain no abrasives. So if light scratches, tar spots etc., are not removed before the wax is applied they will still be visible after waxing. Once a quality wax is in place dirt and grime will not grip the surface so easily, washing will be much easier and your car will look good for longer.
After full paint finish preparation takes place and wax is applied water droplets will bead on the surface. When water beading is not evident it's time to apply wax again.
This example of a black BMW 5 series had been treated roughly in an attempt to remove bird droppings and tree sap. In doing so any protection had been removed. Although the clear coat finish had been badly scuffed in a number of places nothing had fully penetrated to the colour coat beneath. Paint depth measurements were recorded and found satisfactory all over. Although no paint finish is bird dropping proof the sooner this and tree sap is removed the better. When prompt and careful action is taken a 'full recovery' is possible. Every manufacturer will advise a car owner to wax their car at least twice a year. This means putting down a layer of protection to keep most forms of contamination at bay between waxing.
On every occassion this means washing the car paintwork (and wheels) to remove dirt and grime. The use of a clay bar to remove more embedded contaminents can reap surprising rewards. Removing 'dirt' not previously visible lying unnoticed in an even layer all over your car paint finish.
Depending on the condition of the surface of the finish polishing may be required to remove swirl marks etc to restore clear sharp light reflections. Machine polishing in experienced hands can dramatically improve upon what can be achieved when polishing by hand alone.
One of the questions I am often asked is what can you do about scratches in paintwork.
With scratches the first thing to do is the finger nail test. Run your finger nail over the scratches at right angles to them. If your finger nail catches in the scratch, even the slightest, this tells us it is too wide to machine polish out. The scratch may close up a little but alot will depend on how 'stretchable' the paint finish is.
The two photos below of a Mercedes C Class shows lots of swirl marks caused by a poor wash technique starting with using a sponge. These tiny scratches generally are not very deep in the clear coat finish and look like a spiders webb when you see the sun reflected in the paint surface. Because of how these are caused they will most likely be found over the entire bodywork so the whole car will need to be machine polished to erase them.
One panel had a few scratches caused by a pets claw and another panel a long scratch caused by passing too close to a roadside bush.
The next two photos show after Autocare have machine polished these panels.
All the swirl marks have been erased. The long scratch turned out to be not as bad as I had originally thought. No two scratches are exactly the same and so this makes it difficult to precisely predict what is achievable with machine polishing. This pets claw marks were infact very deep but not too wide to close up. These have not completely disappeared but are no where near as visible.
This particular Sky Line had to be perfect as three days later it would lead the cavalcade at Silverstone playing its part in breaking the record for the most Skylines in one place at the same time.
There were numerous blemishes where the paint shop had to flatten drip marks etc. So this would need a complete machine polish and wax to every panel to ensure it looked its best for this very special occassion.
Starting with a rince then wash to the bodywork following the Autocare multi wash system, two bucket method and lambs wool wash mitt. Drying was by micro fibre towel. Next I was anxious to know the paintwork depth. The digital paint depth guage measurements would be citical to the success of this project. The Sky Line had received a complete respray in recent days and before polishing started it is vital to know exactly what the depth of finish is to determine which blemishes can be corrected without compromising the clear coat finish. If ever the clear coat finish is too aggresively mopped or wet sanded the appearance and colour of the finish will, in blotches appear different and the only answer is to respray.
The measurements were fine in this case so I went straight to masking off the delicate areas and choosing mopp head and polish grade combination. Continuing through the polish grades finishing with the finest to bring out a clear reflection. Then apply by hand a cleanser (contains no abrasives just gently cleans the surface and prepares it so the wax bonds fully). Topped off with my favourite Carnauba wax to maximise colour intensity and gloss. The results you see in the five photos took over 8 hours to complete.
As you can see the outside of the vehicle was in need of some 'tlc' but the lady owner, who made it clear she would not be parted from her 'baby', had kept the interior very clean.
First job was to vacuum the soft top roof with a special brush attachment to remove any loose debris. Then treat the fabric with a dedicated roof cleaner and leave to soak. Rinse the cleaning fluid which has now had time to loosen the dirt and inspect for any remaining dirt or staining and retreat if necessary. I can now leave the roof, I will be applying a reproofing treatment to repel water and the ingress of dirt but this will be later as a more even coating is achieved when the hood is dry.
Next job was to rinse the exterior bodywork again and treat with a grime remover to loosen any stuck dirt before rinsing once more. Then wash exterior bodywork with ph balanced shampoo and lambs wool wash mitt. The door boot and bonnet shuts follow and then hand scrub wheel arches. Dry all bodywork, door and boot shuts with microfiber towels.
Cleaning the alloy wheels comes next. This can be a slow job removing all the brake dust, tar spots etc but at the end it always looks well worth the effort.
Next a close assessment of the paintwork then to work with the clay bar. It's important to remove any and all contamination however minute since it can adversely affect the end result. 'It's all in the preparation'.
Next stage to machine polishing. The condition of the paintwork needed only very fine polishing to achieve the desired result. Then clean up the paintwork with a cleanser to ensure the chosen carnauba wax will adhere thoroughly and last longer. As you can see from the reflections in the paintwork the result is pleasing.
Lastly the alloys wheels. These are polished then sealed with a brake dust repellent to slow down the bake dust sticking and corroding the wheels.
The interior comes next not forgetting the door and boot shuts to be polished by hand and adjacent rubber seals cleaned and treated. Plastics and vinyls are dusted with special attention to the air vents, switches etc. then all treated with anti static cleaner which leaves a matt factory finish. Thorough vacuum comes next, carpets, mats, seats and boot (there are two storage areas on this Boxster one front and one rear), followed by shampoo to carpets and mats. The seats are leather so cleaning first. The cars exterior does not show its age but the leather seats are worn and so cleaning must be done carefully with dedicated leather cleaner. To store the leather suppleness and reduce future cracking a leather conditioner is applied. Then the roof linning is wiped clean along with all the mechanism. Rubber seals are treated at the top of the screen. On to the glass not forgetting door mounted mirrors and those under the sun visors. Lastly the leather upholstery has a conditioner applied. Important to regain suppleness and reduce cracking.
Finish off with a matt dressing to the tyres.
Most cars suffer from some sort of contamination to the paintwork at some time during their life. Industrial fall out, tree sap, tar, hard water spots etc. It is vital to safely and correctly remove these contaminents before the process of oxidation starts ruining your paintwork.
I was contacted by a gentleman who had recently purchased the Audi A3 in this case study. He was already aware of the 'staining' of the exterior of his car and felt that this seriously detracted from the overall appearance of his new purchase. The previous owner had told him this was due to frequent parking in a local railway station car park. I agreed with the new owner to inspect the vehicle and suggest a remedial course of action. As you can see from the photos it looks as if the whole car has some sort of 'brownish' staining on it. When you run your finger tips over the surface it feels gritty. Small sharp nudules (iron filings) appear embedded in the surface. This confirmed the contamination had arisen in the station car park.
If left untreated this contamination would, once mixed with our mild acid rain, turn into rusty brown dots, Unfortunately no matter how much washing and polishing by hand you do, it is unlikely to improve things.
In this situation this rail dust is not selective where it adheres to, roof, bonnet boot lid even headlamp lenses. The sun catches the speckles in the paintwork. Windows, rubber seals and alloy wheels too. The pictures capture the mist like staining on the upper panels and window glass, especialy evident outside the wiper arch.
The rectification process started with a thorough wash to the exterior bodywork, wheels and arches. Using ph neutral shampoo, lambs wool wash mitt and the two bucket method to ensure there would be no loose grit carried around the bodywork. This was followed by a specialist commercial only available solution to loosen the long standing contamination. Product training comes into its own here. Next came the contamination removal bar stage using various grades. This is the safest way to remove most types of contamination, tree sap, industrial fall out etc. You can see in the photo the brown staining on the bar after it has been lifted from the bodywork. Great care is needed in order to avert these tiny filings as they are lifted away causing scuffing to the surface. Continuing with all the remaining exterior, windows, rubber trim, alloy wheels etc.
To remove all the contamination it took over 4 hours and 5 separate bars. To finish this stage another wash for the exterior bodywork and dry with a micro fiber towel.
To fully restore the paintwork to better than showroom finish a full machine polish was next. Prior to agreeing the work extensive digital paint depth measurements were taken and recorded to ensure the Audi's paintwork was suitable to machine polish. This is a key step in the process as visual checks can only tell you so much. Simply, without this information to guide you, alot of damage can be done in inexperienced hands. Paint depth measurements are on going throughout the polishing stage to ensure the very minimum of clear coat finish is removed so as not to compromise the clear coat. Various grades of polish were tested to find the best possible combination to achieve the desired effect. It is polishing that gives your car the glossy reflections you see not the waxing. A few small scratches were closed up and alot of swirl marks polished out.
The final result was protected with 55% Carnauba wax which adds a depth of shine too.

lowercased:
autocare of solihull operate a fully mobile vehicle valeting and detailing service throughout the west midlands, warwickshire and further afield.
paintwork protection - why so important?
winter time can really be tough on your car exterior. paintwork and wheels suffer an increase in road grime and, with the cold weather washing can become less frequent. click on images to enlarge them.
before winter sets in its time to apply some long lasting protection so your car is easier to wash and there is less chance of dirt gripping your paintwork and wheels.
autocare wash the exterior body work using our multi wash system, rinsing then treating the bodywork with biodegradeable grime remover. rinsing again them washing the entire car with a ph neutral shampoo, lambs wool wash mitt and the two bucket method (buckets with grit guard to avoid dragging any minute grit particles around your car causing swirl marks).
rinsing and drying follows then the wheels are cleaned with a non acid wheel cleaner to remove brake dust and dirt. then rinse and dry with micro fiber towels.
paintwork is then treated to remove any contamination, tree sap, tar spots and industrial fall out. the cleaner and smoother the surface of paintwork and wheels enables the sealants to perform to there best.
next we cleanse the paintwork and wheels to ensure the surface is ready to receive the sealant. sealants are chosen for this particular valet to seal the surface from the harsh environment. sealants are synthetic waxes formulated for long lasting protective qualities and do not contain any abrasives. they are applied by hand then buffed.
alloy wheels are treated the same but with a dedicated alloy wheel sealant.
keeping your car paint finish looking good for longer.
do water droplets bead on your car paintwork?
applying a layer of wax to your car paintwork finish creates a barrier keeping dirt, grime and other contaminants from reaching the paint finish of your car and starting a process of deterioration. real waxes contain no abrasives. so if light scratches, tar spots etc., are not removed before the wax is applied they will still be visible after waxing. once a quality wax is in place dirt and grime will not grip the surface so easily, washing will be much easier and your car will look good for longer.
after full paint finish preparation takes place and wax is applied water droplets will bead on the surface. when water beading is not evident it's time to apply wax again.
this example of a black bmw 5 series had been treated roughly in an attempt to remove bird droppings and tree sap. in doing so any protection had been removed. although the clear coat finish had been badly scuffed in a number of places nothing had fully penetrated to the colour coat beneath. paint depth measurements were recorded and found satisfactory all over. although no paint finish is bird dropping proof the sooner this and tree sap is removed the better. when prompt and careful action is taken a 'full recovery' is possible. every manufacturer will advise a car owner to wax their car at least twice a year. this means putting down a layer of protection to keep most forms of contamination at bay between waxing.
on every occassion this means washing the car paintwork (and wheels) to remove dirt and grime. the use of a clay bar to remove more embedded contaminents can reap surprising rewards. removing 'dirt' not previously visible lying unnoticed in an even layer all over your car paint finish.
depending on the condition of the surface of the finish polishing may be required to remove swirl marks etc to restore clear sharp light reflections. machine polishing in experienced hands can dramatically improve upon what can be achieved when polishing by hand alone.
one of the questions i am often asked is what can you do about scratches in paintwork.
with scratches the first thing to do is the finger nail test. run your finger nail over the scratches at right angles to them. if your finger nail catches in the scratch, even the slightest, this tells us it is too wide to machine polish out. the scratch may close up a little but alot will depend on how 'stretchable' the paint finish is.
the two photos below of a mercedes c class shows lots of swirl marks caused by a poor wash technique starting with using a sponge. these tiny scratches generally are not very deep in the clear coat finish and look like a spiders webb when you see the sun reflected in the paint surface. because of how these are caused they will most likely be found over the entire bodywork so the whole car will need to be machine polished to erase them.
one panel had a few scratches caused by a pets claw and another panel a long scratch caused by passing too close to a roadside bush.
the next two photos show after autocare have machine polished these panels.
all the swirl marks have been erased. the long scratch turned out to be not as bad as i had originally thought. no two scratches are exactly the same and so this makes it difficult to precisely predict what is achievable with machine polishing. this pets claw marks were infact very deep but not too wide to close up. these have not completely disappeared but are no where near as visible.
this particular sky line had to be perfect as three days later it would lead the cavalcade at silverstone playing its part in breaking the record for the most skylines in one place at the same time.
there were numerous blemishes where the paint shop had to flatten drip marks etc. so this would need a complete machine polish and wax to every panel to ensure it looked its best for this very special occassion.
starting with a rince then wash to the bodywork following the autocare multi wash system, two bucket method and lambs wool wash mitt. drying was by micro fibre towel. next i was anxious to know the paintwork depth. the digital paint depth guage measurements would be citical to the success of this project. the sky line had received a complete respray in recent days and before polishing started it is vital to know exactly what the depth of finish is to determine which blemishes can be corrected without compromising the clear coat finish. if ever the clear coat finish is too aggresively mopped or wet sanded the appearance and colour of the finish will, in blotches appear different and the only answer is to respray.
the measurements were fine in this case so i went straight to masking off the delicate areas and choosing mopp head and polish grade combination. continuing through the polish grades finishing with the finest to bring out a clear reflection. then apply by hand a cleanser (contains no abrasives just gently cleans the surface and prepares it so the wax bonds fully). topped off with my favourite carnauba wax to maximise colour intensity and gloss. the results you see in the five photos took over 8 hours to complete.
as you can see the outside of the vehicle was in need of some 'tlc' but the lady owner, who made it clear she would not be parted from her 'baby', had kept the interior very clean.
first job was to vacuum the soft top roof with a special brush attachment to remove any loose debris. then treat the fabric with a dedicated roof cleaner and leave to soak. rinse the cleaning fluid which has now had time to loosen the dirt and inspect for any remaining dirt or staining and retreat if necessary. i can now leave the roof, i will be applying a reproofing treatment to repel water and the ingress of dirt but this will be later as a more even coating is achieved when the hood is dry.
next job was to rinse the exterior bodywork again and treat with a grime remover to loosen any stuck dirt before rinsing once more. then wash exterior bodywork with ph balanced shampoo and lambs wool wash mitt. the door boot and bonnet shuts follow and then hand scrub wheel arches. dry all bodywork, door and boot shuts with microfiber towels.
cleaning the alloy wheels comes next. this can be a slow job removing all the brake dust, tar spots etc but at the end it always looks well worth the effort.
next a close assessment of the paintwork then to work with the clay bar. it's important to remove any and all contamination however minute since it can adversely affect the end result. 'it's all in the preparation'.
next stage to machine polishing. the condition of the paintwork needed only very fine polishing to achieve the desired result. then clean up the paintwork with a cleanser to ensure the chosen carnauba wax will adhere thoroughly and last longer. as you can see from the reflections in the paintwork the result is pleasing.
lastly the alloys wheels. these are polished then sealed with a brake dust repellent to slow down the bake dust sticking and corroding the wheels.
the interior comes next not forgetting the door and boot shuts to be polished by hand and adjacent rubber seals cleaned and treated. plastics and vinyls are dusted with special attention to the air vents, switches etc. then all treated with anti static cleaner which leaves a matt factory finish. thorough vacuum comes next, carpets, mats, seats and boot (there are two storage areas on this boxster one front and one rear), followed by shampoo to carpets and mats. the seats are leather so cleaning first. the cars exterior does not show its age but the leather seats are worn and so cleaning must be done carefully with dedicated leather cleaner. to store the leather suppleness and reduce future cracking a leather conditioner is applied. then the roof linning is wiped clean along with all the mechanism. rubber seals are treated at the top of the screen. on to the glass not forgetting door mounted mirrors and those under the sun visors. lastly the leather upholstery has a conditioner applied. important to regain suppleness and reduce cracking.
finish off with a matt dressing to the tyres.
most cars suffer from some sort of contamination to the paintwork at some time during their life. industrial fall out, tree sap, tar, hard water spots etc. it is vital to safely and correctly remove these contaminents before the process of oxidation starts ruining your paintwork.
i was contacted by a gentleman who had recently purchased the audi a3 in this case study. he was already aware of the 'staining' of the exterior of his car and felt that this seriously detracted from the overall appearance of his new purchase. the previous owner had told him this was due to frequent parking in a local railway station car park. i agreed with the new owner to inspect the vehicle and suggest a remedial course of action. as you can see from the photos it looks as if the whole car has some sort of 'brownish' staining on it. when you run your finger tips over the surface it feels gritty. small sharp nudules (iron filings) appear embedded in the surface. this confirmed the contamination had arisen in the station car park.
if left untreated this contamination would, once mixed with our mild acid rain, turn into rusty brown dots, unfortunately no matter how much washing and polishing by hand you do, it is unlikely to improve things.
in this situation this rail dust is not selective where it adheres to, roof, bonnet boot lid even headlamp lenses. the sun catches the speckles in the paintwork. windows, rubber seals and alloy wheels too. the pictures capture the mist like staining on the upper panels and window glass, especialy evident outside the wiper arch.
the rectification process started with a thorough wash to the exterior bodywork, wheels and arches. using ph neutral shampoo, lambs wool wash mitt and the two bucket method to ensure there would be no loose grit carried around the bodywork. this was followed by a specialist commercial only available solution to loosen the long standing contamination. product training comes into its own here. next came the contamination removal bar stage using various grades. this is the safest way to remove most types of contamination, tree sap, industrial fall out etc. you can see in the photo the brown staining on the bar after it has been lifted from the bodywork. great care is needed in order to avert these tiny filings as they are lifted away causing scuffing to the surface. continuing with all the remaining exterior, windows, rubber trim, alloy wheels etc.
to remove all the contamination it took over 4 hours and 5 separate bars. to finish this stage another wash for the exterior bodywork and dry with a micro fiber towel.
to fully restore the paintwork to better than showroom finish a full machine polish was next. prior to agreeing the work extensive digital paint depth measurements were taken and recorded to ensure the audi's paintwork was suitable to machine polish. this is a key step in the process as visual checks can only tell you so much. simply, without this information to guide you, alot of damage can be done in inexperienced hands. paint depth measurements are on going throughout the polishing stage to ensure the very minimum of clear coat finish is removed so as not to compromise the clear coat. various grades of polish were tested to find the best possible combination to achieve the desired effect. it is polishing that gives your car the glossy reflections you see not the waxing. a few small scratches were closed up and alot of swirl marks polished out.
the final result was protected with 55% carnauba wax which adds a depth of shine too.


text:
We’re hard at work putting together the schedule of Obedience Trials that will be offered at the 2019 DKC Dog Shows. Be sure to check back to get all the information available for exhibitors and spectators alike!
The Detroit Kennel Club is pleased to be offering the following Special Event Trials during the 2019 DKC Dog Shows. For more information including entry requirements, trial dates, etc., please click on the links below.
Trials held on June 22 and June 23. Click here for more information.
Testing for AKC Canine Good Citizen (CGC), AKC Community Canine (CGCA), and Therapy Dogs International (TDI) certification will be held on June 22 and 23. Click here for more information.
Trials held on Sunday, June 23 only. Click here for more information.

lowercased:
we’re hard at work putting together the schedule of obedience trials that will be offered at the 2019 dkc dog shows. be sure to check back to get all the information available for exhibitors and spectators alike!
the detroit kennel club is pleased to be offering the following special event trials during the 2019 dkc dog shows. for more information including entry requirements, trial dates, etc., please click on the links below.
trials held on june 22 and june 23. click here for more information.
testing for akc canine good citizen (cgc), akc community canine (cgca), and therapy dogs international (tdi) certification will be held on june 22 and 23. click here for more information.
trials held on sunday, june 23 only. click here for more information.


text:
Headquartered in Alexandria, Virginia, Carney develops web-based learning and knowledge management solutions primarily for government agencies.
With three separate systems for project management, cost accounting, and timesheet reporting, Carney could not easily share data across the systems, which limited the company’s ability to expand and hindered data storage and productivity. Carney realized that it had outgrown its systems and needed to upgrade its business systems into one powerful system.
Therefore, Carney began to evaluate cost accounting and project management solutions to streamline internal processes.
Technology Solution: Carney worked with Brittenford Systems to implement Microsoft® Business Solutions–Solomon for accounting functions and Microsoft Project Server 2002 for project management capabilities. Carney also uses Microsoft Office Professional Edition 2003 for many internal business practices.
For full details, view the full case study (PDF).
For more information on financial management for professional services organizations please visit our website, or check out Microsoft Dynamics GP for Professional Services (PDF).

lowercased:
headquartered in alexandria, virginia, carney develops web-based learning and knowledge management solutions primarily for government agencies.
with three separate systems for project management, cost accounting, and timesheet reporting, carney could not easily share data across the systems, which limited the company’s ability to expand and hindered data storage and productivity. carney realized that it had outgrown its systems and needed to upgrade its business systems into one powerful system.
therefore, carney began to evaluate cost accounting and project management solutions to streamline internal processes.
technology solution: carney worked with brittenford systems to implement microsoft® business solutions–solomon for accounting functions and microsoft project server 2002 for project management capabilities. carney also uses microsoft office professional edition 2003 for many internal business practices.
for full details, view the full case study (pdf).
for more information on financial management for professional services organizations please visit our website, or check out microsoft dynamics gp for professional services (pdf).


text:
My research aims to improve our understanding of how cells with the same genome can develop dramatically different behaviors. For example, consider the mechanical abilities of a muscle cell compared to the electrical excitability of a neuron, or the industrious activity of bone building cells in a youthful person compared to an elderly one. Each of these cells, (if taken from the same individual) has an identical genome — and yet each is “reading” a very distinct subset of that genome and consequently carrying out very different behaviors. The choice of what to read and what to hide away is made during development. An increasing body of data suggests this is accomplished by modifying the genome both in the nature of the proteins bound to different sequences and in the spatial organization of those sequences relative to each other. The spatial organization or folding of the genome may be particularly important in complex multicellular organisms, since many of the sequences known to interact based on genetic data are nonetheless substantially separated from each other along the linear genome. By regulating the folding of this linear sequence into a higher order structure, a cell might change which regulatory sequences have access to which genes, and achieve different behavioral states.
So far we have little imaging data on how the genome is folded within a cell on the length scale of individual genes, or whether this folding is regulated in any way relevant to the behavior of the cell. Our limited knowledge stems largely from want of a method that has both the resolution and specificity to visualize such genomic substructure. Conventional fluorescent microscopy has developed excellent tools for coloring specific regions of DNA and particular DNA-associated proteins with uniquely colored dyes — but lacks the resolution to turn these colored blurs into structures. Electron-microscopy has substantially greater resolution but lacks compatibility with specific labeling techniques to tell different gene clusters or different protein types apart. Super-resolution imaging approaches promise to address this balance by allowing the use of fluorescent labels while simultaneously resolving structures on the nano-scale. I have been adapting this approach to uncover the nano-scale structure of chromatin and determine to how this structure changes when bound by different types of nuclear proteins. While individual gene clusters appear as quite diverse structures, there appear to be a few general features, for example, linking structure with the epigenetic state.

lowercased:
my research aims to improve our understanding of how cells with the same genome can develop dramatically different behaviors. for example, consider the mechanical abilities of a muscle cell compared to the electrical excitability of a neuron, or the industrious activity of bone building cells in a youthful person compared to an elderly one. each of these cells, (if taken from the same individual) has an identical genome — and yet each is “reading” a very distinct subset of that genome and consequently carrying out very different behaviors. the choice of what to read and what to hide away is made during development. an increasing body of data suggests this is accomplished by modifying the genome both in the nature of the proteins bound to different sequences and in the spatial organization of those sequences relative to each other. the spatial organization or folding of the genome may be particularly important in complex multicellular organisms, since many of the sequences known to interact based on genetic data are nonetheless substantially separated from each other along the linear genome. by regulating the folding of this linear sequence into a higher order structure, a cell might change which regulatory sequences have access to which genes, and achieve different behavioral states.
so far we have little imaging data on how the genome is folded within a cell on the length scale of individual genes, or whether this folding is regulated in any way relevant to the behavior of the cell. our limited knowledge stems largely from want of a method that has both the resolution and specificity to visualize such genomic substructure. conventional fluorescent microscopy has developed excellent tools for coloring specific regions of dna and particular dna-associated proteins with uniquely colored dyes — but lacks the resolution to turn these colored blurs into structures. electron-microscopy has substantially greater resolution but lacks compatibility with specific labeling techniques to tell different gene clusters or different protein types apart. super-resolution imaging approaches promise to address this balance by allowing the use of fluorescent labels while simultaneously resolving structures on the nano-scale. i have been adapting this approach to uncover the nano-scale structure of chromatin and determine to how this structure changes when bound by different types of nuclear proteins. while individual gene clusters appear as quite diverse structures, there appear to be a few general features, for example, linking structure with the epigenetic state.


text: “Always refreshing to have a builder that is accessible. Steve Zuk provides you with his cell phone and encourages you to call with any questions. If he is unable to answer your call, which in my experience is rare, he is always prompt about getting right back to you." Our home building process went very smooth and worry-free, thanks to Steve Zuk.

lowercased: “always refreshing to have a builder that is accessible. steve zuk provides you with his cell phone and encourages you to call with any questions. if he is unable to answer your call, which in my experience is rare, he is always prompt about getting right back to you." our home building process went very smooth and worry-free, thanks to steve zuk.