Jingyuan Xie,Mo Chen,Hedong Han,Ke Xu,Guihuan Qiu,Xinqing Lin,Yong Song,Jinjun Ye,Tangfeng Lv,Ping Zhan
Clinical impact of first‐line PD ‐1 or PD‐L1 inhibitors combined with chemotherapy in extensive‐stage small cell lung cancer patients: A real‐world multicenter propensity score‐matched study
extensive‐stage SCLC,PD‐1 inhibitors,PD‐L1 inhibitors,propensity score‐matched analysis,risk factors
Abstract Objectives Our research aimed to evaluate the effectiveness of first‐line immune checkpoint inhibitors (ICIs) with etoposide and platinum (EP) for extensive‐stage small cell lung cancer (ES‐SCLC) and identify prognostic factors, as real‐world outcomes and the inconsistency of PD‐1 and PD‐L1 inhibitors are uncertain. Methods We selected ES‐SCLC patients in three centers and conducted a propensity score‐matched analysis. The Kaplan–Meier method and Cox proportional hazards regression were conducted to compare the survival outcomes. We also performed univariate and multivariate Cox regression analyses to investigate predictors. Results Among 236 patients included, 83 pairs of cases were matched. The EP plus ICIs cohort had a longer median overall survival (OS) (17.3 months) than the EP cohort (13.4 months) (hazard ratio [HR], 0.61 [0.45, 0.83]; p = 0.001). The median progression‐free survival (PFS) was also longer in the EP plus ICIs cohort (8.3 months) than in the EP cohort (5.9 months) (HR, 0.44 [0.32, 0.60]; p < 0.001). The EP plus ICIs group had a higher objective response rate (ORR) (EP: 62.3%, EP + ICIs: 84.3%, p < 0.001). Multivariate analysis presented that liver metastases (HR, 2.08; p = 0.018) and lymphocyte–monocyte ratio (LMR) (HR, 0.54; p = 0.049) were independent prognostic factors for OS, and performance status (PS) (HR, 2.11; p = 0.015), liver metastases (HR, 2.64; p = 0.002), and neutrophil‐lymphocyte ratio (NLR) (HR, 0.45; p = 0.028) were for PFS in patients with chemo‐immunotherapy. Conclusion Our real‐world data demonstrated that ICIs with chemotherapy as the first‐line setting for ES‐SCLC are effective and safe. PS, liver metastases, and inflammatory markers could serve as valuable risk factors.
Clinical impact of first‐line PD ‐1 or PD‐L1 inhibitors combined with chemotherapy in extensive‐stage small cell lung cancer patients: A real‐world multicenter propensity score‐matched study

Our research aimed to evaluate the effectiveness of first‐line immune checkpoint inhibitors (ICIs) with etoposide and platinum (EP) for extensive‐stage small cell lung cancer (ES‐SCLC) and identify prognostic factors, as real‐world outcomes and the inconsistency of PD‐1 and PD‐L1 inhibitors are uncertain.

We selected ES‐SCLC patients in three centers and conducted a propensity score‐matched analysis. The Kaplan–Meier method and Cox proportional hazards regression were conducted to compare the survival outcomes. We also performed univariate and multivariate Cox regression analyses to investigate predictors.

Among 236 patients included, 83 pairs of cases were matched. The EP plus ICIs cohort had a longer median overall survival (OS) (17.3 months) than the EP cohort (13.4 months) (hazard ratio [HR], 0.61 [0.45, 0.83]; p = 0.001). The median progression‐free survival (PFS) was also longer in the EP plus ICIs cohort (8.3 months) than in the EP cohort (5.9 months) (HR, 0.44 [0.32, 0.60]; p < 0.001). The EP plus ICIs group had a higher objective response rate (ORR) (EP: 62.3%, EP + ICIs: 84.3%, p < 0.001). Multivariate analysis presented that liver metastases (HR, 2.08; p = 0.018) and lymphocyte–monocyte ratio (LMR) (HR, 0.54; p = 0.049) were independent prognostic factors for OS, and performance status (PS) (HR, 2.11; p = 0.015), liver metastases (HR, 2.64; p = 0.002), and neutrophil‐lymphocyte ratio (NLR) (HR, 0.45; p = 0.028) were for PFS in patients with chemo‐immunotherapy.

Our real‐world data demonstrated that ICIs with chemotherapy as the first‐line setting for ES‐SCLC are effective and safe. PS, liver metastases, and inflammatory markers could serve as valuable risk factors.

Small cell lung cancer (SCLC), neuroendocrine cancer that accounts for ~ 15% of lung cancer patients worldwide, is known for its aggressive progression. Unfortunately, the prognosis for cases with SCLC is poor, with a 5‐year survival rate of only 5%, largely because of the rapid growth of the tumor and early development of metastases. , The majority of SCLC cases are classified as extensive‐stage (ES) SCLC, accounting for approximately two‐thirds of all diagnoses. The traditional first‐line setting for ES‐SCLC in the past two decades has been chemotherapy consisting of etoposide combined with platinum (EP). Although chemotherapy could elicit a response in 60% to 80% of ES‐SCLC patients, complete remission was observed in only 15% to 20%, and most patients relapsed soon after initial treatment. , With the advancement of immunotherapy and an improved understanding of tumor immunity, its application in clinical settings has been on the rise. As some studies reported, chemotherapy could modulate the tumor microenvironment by inducing immunogenic cell death, the majority of chemotherapeutic drugs have demonstrated immunostimulatory effects, such as increasing immunogenicity and T‐cell infiltration, activating effector cells, and suppressing immunosuppressive cells. , This preclinical evidence provides the rationale for combining chemotherapy and immune checkpoint inhibitors (ICIs). Two recent randomized phase three trials (CASPIAN and IMpower133) showed that the addition of programmed death ligand 1 (PD‐L1) inhibitor to EP has been shown to significantly improve both overall survival (OS) and progression‐free survival (PFS) when in comparison with chemotherapy alone. , Such benefit is relatively small and was not even observed in the KEYNOTE‐604 study that used the programmed death 1 (PD‐1) inhibitor pembrolizumab, this study confirmed that the addition of pembrolizumab to chemotherapy prolonged OS, but the significance threshold was not met. However, ASTRUM‐005 study published in 2022 that used Serplulimab (another PD‐1 inhibitor) combined with chemotherapy reached a significant OS benefit. The inconsistent results raised the question about the optimal chemotherapy and immunotherapy combination in the first‐line setting for ES‐SCLC cases, with particular attention given to the choice between anti‐PD‐1 agents and anti‐PD‐L1 agents. Therefore, it is essential to carefully weigh the benefits and threats of ICIs combined with chemotherapy for patients with ES‐SCLC. Moreover, to exactly stratify ES‐SCLC patients who could take advantage of chemotherapy with ICIs, it is essential to find reliable prognostic factors. Systemic inflammatory responses have been confirmed to be associated with the development and spread of malignancies. As a result, some inflammatory and nutritional markers have an intriguing role in clinical practice as prognostic factors, for example, systemic inflammation response index (SIRI) and prognostic nutrition index (PNI). , , , However, the predictive value of these markers for ES‐SCLC cases who received chemotherapy with ICIs remains uncertain. In this multicenter and retrospective study, we analyzed the therapeutic effect of immunotherapy (PD‐L1 inhibitors or PD‐1 inhibitors) combined with EP and EP alone in real‐world clinical cases of ES‐SCLC to offer a reference for clinical treatment. At the same time, we carried out a propensity score‐matched analysis to minimalize the bias brought on by the patients’ baseline characteristics. Besides the comparison of survival outcomes, we conducted a multivariate analysis based on the clinical characteristics and serum inflammatory and tumor markers of patients to identify the independent prognostic factors of ES‐SCLC cases who received ICIs in combination with chemotherapy.

Our multicenter and retrospective study was carried out in compliance with the amended Declaration of Helsinki and got approval from the appropriate ethical committees of Jinling Hospital (Ethics number: 202103275). Because this study was retrospective in design, informed consent from the patients who were enrolled in it was not required, and patients’ information was secured. This study selected SCLC patients who were treated at three institutions (Jinling Hospital, Jiangsu Cancer Hospital, and The First Affiliated Hospital of Guangzhou Medical University) between June 2019 and March 2021. Histologically or cytologically confirmed SCLC, first‐line standard chemotherapy consisting of etoposide plus platinum with or without immunotherapy, and systematic classification into extensive disease according to Veterans Administration Lung Study Group before treatment were required for participation in this study. Additionally, the patients who only received 1 to 2 cycles of therapy or had a history of another tumor were excluded.

The Kaplan–Meier (K–M) method was carried out to estimate PFS and OS to assess the time from first‐line therapy to relapse or death. On the ground of Response Evaluation Criteria in Solid Tumors, the response to chemotherapy or chemo‐immunotherapy was evaluated. The calculation of objective response rate (ORR) was based on the proportion of cases that attained complete response (CR) and partial response (PR), whereas the disease control rate (DCR) was based on the proportion of cases that attained complete or PR as well as stable disease (SD). Patient information before treatment, including age, sex, smoking history, Eastern Cooperative Oncology Group (ECOG) performance status (PS), baseline information of tumor, count of leukocyte, neutrophil, lymphocyte, monocyte, and platelet, lactate dehydrogenase (LDH), serum albumin, tumor markers, and weight and height, was collected. Several indexes have been used to assess inflammation and nutritional status in our study, including the following: neutrophil–lymphocyte ratio (NLR) = neutrophil/lymphocyte; platelet–lymphocyte ratio (PLR) = platelet/lymphocyte; lymphocyte–monocyte ratio (LMR) = lymphocyte/monocyte; systemic immune‐inflammation index (SII) = platelet × NLR ; SIRI = neutrophil × monocyte/lymphocyte ; PNI = serum albumin (g/L) + 5 × total lymphocyte count (109/L) ; body mass index (BMI) = weight(kg)/height(m)2; and advanced lung cancer inflammation index (ALI) = BMI × (serum albumin/NLR). The baseline LDH level and the dNLR (derived neutrophil‐lymphocyte ratio: neutrophil count/[white blood cell count–neutrophil count]) level were used to calculate the lung immune prognostic index (LIPI). NLR, PLR, LMR, SII, SIRI, PNI, and ALI are transformed into classification variables by the optimal cutoff value of the receiver operating curve (ROC). LDH and tumor markers are transformed into classification variables by the upper limit of normal (ULN).

The baseline characters of the included patients were analyzed by using descriptive statistics, including frequencies and percentages. Categorical variables were assessed using the χ2‐square test and the Kruskal–Wallis test. Propensity score‐matching was conducted using a 1:1 matching design with a tolerance of 0.05. A logistic regression model was conducted to estimate the propensity score, which included the following covariates: age, sex, PS, smoking status, primary site, presence of distant metastases, and lymph node metastases, presence of pleural effusion and pericardial effusion, and the history of radiation therapy. Survival analyses were performed using the Kaplan–Meier (K–M) method with the log‐rank test, as well as Cox proportional hazards regression analysis was carried out to compare the two groups. To investigate predictors for OS and PFS, univariate and multivariate Cox regression analyses were carried out on all patients who received chemotherapy combined with immunotherapy before matching. In the univariate analysis, factors that presented a significant association with the risk of OS or PFS (p < 0.05) were included in the subsequent multivariate Cox regression analysis. All the analyses were conducted by R software (version 4.2.2) and SPSS 25.0 software. A statistically significant difference was defined as a p‐value of <0.05.

Of the 382 patients in the initial set, 236 were eligible for inclusion, including 120 patients who received first‐line EP alone and 116 patients who received first‐line EP plus ICIs (Figure S1). The baseline characters of all eligible 236 patients are presented in Table 1. At baseline, 45 (19.1%) patients had brain metastases and 61 (25.8%) patients had liver metastases. The number of cases treated with anti‐PD‐1 agents and anti‐PD‐L1 agents was 72 (30.5%) and 44 (18.6%), respectively. Propensity score‐matching resulted in two groups of 83 patients each, with comparable baseline characters (p > 0.05) (Table 1).

The survival outcomes were analyzed by K–M curves. The median OS (mOS) was 17.3 months (95% confidence interval [CI] [14.5–20.1]) in the EP plus ICIs cohort and 13.4 months (95% CI [11.8–15.1]) in the EP cohort (HR, 0.61 [0.45, 0.83]; p = 0.001) (Figure 1(a)). Similarly, the median progression‐free survival (mPFS) was also longer in the EP plus ICIs cohort (8.3 months; 95% CI [7.0–9.7]) than in the EP cohort (5.9 months; 95% CI [5.2–6.5]) (HR, 0.44 [0.32, 0.60]; p < 0.001) (Figure 1(b)). The benefit of anti‐PD‐1/PD‐L1 agents in terms of OS and PFS was consistently evident in the majority of the predetermined subgroups of patients, which were categorized based on baseline clinical and demographic characteristics (Figure 1(c),(d)). In addition, it is worth mentioning that females (OS: p = 0.245; PFS: p = 0.313), and patients with brain metastases (OS: p = 0.375; PFS: p = 0.510), liver metastases (OS: p = 0.483; PFS: p = 0.409), and pericardial effusion (OS: p = 0.603; PFS: p = 0.141) at initial diagnosis failed to benefit from immunotherapy combined with chemotherapy regardless of OS or PFS (Figure 1(c),(d)). As described in the statistical methods, propensity score matching was carried out. The mOS of cases treated with chemotherapy and immunotherapy was 17.7 months (95% CI [14.6–20.8]), which was longer than the cases treated with chemotherapy alone (12.8 months; 95% CI [10.4–15.2]) (HR, 0.59 [0.41, 0.85]; p = 0.005) (Figure 2(a)). At the same time, the mPFS was longer in the EP plus ICIs cohort (8.0 months; 95% CI [6.3–9.8]) than in the EP cohort (6.0 months; 95% CI [4.8–7.2]) (HR, 0.52 [0.36, 0.75]; p < 0.001) (Figure 2(b)). The results are consistent before and after the matching.

The response was assessed in patients who had complete information. The ORR and DCR of all patients included were 73.0% and 96.8%. The ORR of EP alone, EP plus PD‐1 inhibitors, and EP plus PD‐L1 inhibitors were 62.3%, 87.9%, and 78.6%, respectively. The DCR of them were 94.7%, 100%, and 97.6%, respectively. A significant difference in the ORR between the EP plus ICIs cohort and the EP cohort was found, but no significant difference in the DCR was observed (ORR: EP: 62.3%, EP + ICIs: 84.3%, p < 0.001; DCR: EP: 94.7%, EP + ICIs: 99.1%, p = 0.143) (Figure 3(a)). The treatment‐related adverse events (trAEs) are summarized in Figure 3(b). Among all eligible patients, 191 (90.1%) had encountered at least one trAE, including 109 (51.4%) and 82 (38.7%) patients with grade 1–2 and grade 3–4 trAEs, respectively. The rates of trAEs in the two groups were not statistically significant (p = 0.742).

We conducted the univariate and multivariate analysis in terms of PFS and OS to determine, which clinical characteristics or serum inflammatory and tumor markers are linked to the survival of ES‐SCLC patients who underwent first‐line chemotherapy in combination with ICIs, which was summarized in Table 2. The outcomes of the univariate analysis revealed that ECOG PS (p = 0.043), liver metastases (p < 0.001), baseline NLR (p = 0.017), and baseline SII (p = 0.030) were associated with better PFS in ES‐SCLC cases that received first‐line ICIs treatment. After multivariate analysis, the outcomes presented that ECOG PS = 1 (HR, 2.11; 95% CI [1.15–3.86]; p = 0.015), liver metastases (HR, 2.64; 95% CI [1.41–4.94]; p = 0.002), and baseline NLR >3.10 (HR, 0.45; 95% CI [0.22–0.92]; p = 0.028) were independent prognostic factors for PFS (Table 2). Our results also indicated that smoking history (p = 0.024), brain metastases (p = 0.048), liver metastases (p = 0.010), and baseline LMR (p = 0.031) were significantly linked to better OS through univariate analysis. In the multivariate analysis, we identified liver metastases (HR, 2.08; 95% CI [1.13–3.82]; p = 0.018) and baseline LMR >3.26 (HR, 0.54; 95% CI [0.30–0.99]; p = 0.049) as independent prognostic factors for OS in cases received first‐line chemotherapy combined with ICIs (Table 2).

No statistically significant difference in survival outcomes (OS: HR, 1.47 95% CI [0.92–2.34], p = 0.108; PFS: HR, 0.94, 95% CI [0.58–1.52], p = 0.791) was found between cases who treated with PD‐L1 inhibitors and cases who treated with PD‐1 inhibitors (Figure 4). Moreover, ORR, DCR, and the trAEs in the EP plus PD‐1 inhibitors cohort and the EP plus PD‐L1 inhibitors cohort were similar. (ORR: p = 0.195; DCR: p = 0.389; trAEs: p = 0.124) (Figure 3).

We have summarized a table to compare the basic information from our multi‐center retrospective study with those clinical trials published before. Our survival outcomes were numerically better than previous clinical trials (IMpower133 and CASPIAN) but similar to the more recent trials CAPSTONE‐1 and ASTRUM‐005. The proportion of males and patients with ECOG PS = 0 at enrollment in our study was higher than in the clinical trials and cases with a history of smoking and liver metastases were less in our study (Table 3).

The past decade has witnessed a significant shift in the clinical treatment landscape of solid tumors with the introduction of ICIs. , Although ES‐SCLC has traditionally had a poor prognosis, recent phase three trials have confirmed improved outcomes with the addition of ICIs to chemotherapy. , , , However, only a few retrospective studies reported the survival outcomes in the real world, some without control groups, , some with insufficient case numbers, , and some including only PD‐L1 inhibitors. , , Concerns about the inconsistency of anti‐PD‐1 agents and anti‐PD‐L1 agents suggested by the consequences of clinical trials are inconclusive. , The clinical benefits obtained from ICIs therapy in real‐world ES‐SCLC patients are still worth exploring. Moreover, tumor mutational burden (TMB) and PD‐L1 expression have not demonstrated clear predictive value in ES‐SCLC patients receiving chemotherapy plus immunotherapy in the first‐line setting. No broadly accepted biomarkers that predict benefits from ICIs have been identified to date. As a result, identifying biomarkers to predict the optimal population to benefit from chemo‐immunotherapy has become a priority for oncologists. Our retrospective study was conducted across three medical centers and confirmed the effectiveness and safety of combining ICIs with EP in the first‐line setting of ES‐SCLC patients. In our data, PFS and OS were longer in the cases treated with chemotherapy and immunotherapy, which is consistent with the results of the recent randomized phase three trials. , , , The ORR was ~22% points higher in cases with EP plus ICIs than in cases with EP (84.3% vs. 62.3%). Additionally, our subgroup analysis found consistent benefits in most subgroups, although females and patients with brain metastases, liver metastases, and pericardial effusion failed to benefit from the combination therapy. The published clinical trials mentioned above also found that patients with brain or liver metastases at enrollment did not have a better survival outcome even with immunotherapy. , , , This may be linked to the poorer initial physical condition of these cases. It is worth noting that our survival outcomes in patients treated with ICIs and chemotherapy were numerically better than those of the IMpower133 and CASPIAN. , However, the latest clinical trials (CAPSTONE‐1 and ASTRUM‐005) reached better survival outcomes, which were similar to our data, proving that our findings remain reliable. , The CAPSTONE‐1 study was a multicenter trial conducted in 47 hospitals in China and the ASTRUM‐005 study included two‐thirds of Asian patients. Our study also included patients from three Chinese centers. These suggest that the better survival outcomes may be because of the Asian patient cohort. Based on the comparison, we could speculate that the longer survival outcomes in our study are associated with a higher proportion of males, PS = 0, no history of smoking, and no liver metastases at enrollment. This is also consistent with our following conclusion that liver metastases and ECOG PS are independent prognostic factors according to multivariate cox regression analysis. The differences in survival outcomes also may be because of the limitation of the retrospective study, such as the frequency of evaluation of the response to chemotherapy or chemo‐immunotherapy. In addition, rates of trAEs were similar in the two cohorts, also confirming the safety of the ICIs. According to our findings, no significant difference was observed between cases that received anti‐PD‐1 or anti‐PD‐L1 agents, although the outcomes were longer numerically in the PD‐1 group. The KEYNOTE‐604 study, which used anti‐PD‐1 agents, has not achieved consistent results as the clinical trials with PD‐L1 inhibitors. One notable exception to this trend is the ASTRUM‐005 study, in which the OS reached 15.4 months with the use of Serplulimab. It is the most significant OS benefit among the trials that have been published so far. Because of the absence of head‐to‐head comparisons, some meta‐analyses have been carried out to compare the clinical effectiveness of these two different ICIs indirectly. One meta‐analysis involving 23 studies published between 2013 and 2016 found that anti‐PD‐1 agents and anti‐PD‐L1 agents are likely to have comparable toxicity and effectiveness. However, another meta‐analysis published in 2019 suggested that PD‐1 inhibitors were linked to favorable survival results compared with PD‐L1 inhibitors. The debate on whether PD‐1 and PD‐L1 inhibitors cause different clinical outcomes remains unresolved and more investigation is required. Multivariate analysis of our study showed that ECOG PS = 1, liver metastases, and baseline NLR ≤3.10 were independent risk factors for PFS, and liver metastases and baseline LMR ≤3.26 were for OS. Recently, increasing evidence suggests that performance status has a significant impact on tumor development and our research supported this. Many previous studies and ours have reached the same result that liver metastases were associated with a poorer prognosis. According to Yu et al. liver metastases reduced the amount of circulating CD8+ T cells through the apoptosis of activated T cells following their interaction with macrophages, and liver‐directed radiotherapy reduced macrophages to increase the anticancer effectiveness of immunotherapy in preclinical models. If this theory is supported by additional prospective studies, careful monitoring of the liver metastases progression and application of local therapy to liver metastases would probably increase the efficacy of immunotherapy and help to improve survival rates. At several stages of tumor growth, inflammatory responses are crucial. Some indexes related to inflammation and nutritional status, such as the NLR, SIRI, and LIPI, have been identified as valuable prognostic factors for some cancers. , , , However, it remains unclear if these markers still have a similar effect in cases with ES‐SCLC. Qi et al. found that several baseline factors were discovered to be significantly associated with OS outcomes for ES‐SCLC cases who received chemotherapy and atezolizumab, including NLR, PLR, LMR, SII, PNI, and LIPI. In the multivariate analysis, PLR was the only independent prognostic factor identified. Our study similarly explored the prognostic effect of the pretreatment inflammatory and nutritional markers for ES‐SCLC patients, who received first‐line chemo‐immunotherapy, and we identified NLR and LMR have potential predictive value. The underlying mechanisms of the link between decreased NLR/LMR and poor survival outcomes in SCLC cases remain unclear. Galvano et al. conducted a study to find out that lung neuroendocrine carcinoma patients with elevated NLR demonstrated an augmented likelihood of poor outcomes. Additionally, a previous study discovered that increased neutrophils induced the upregulation of cytokines and chemokines, which may have facilitated the development of cancers. These findings, in contrast to our results, suggested that the effect of NLR on tumor development is to a large extent unknown, particularly after the addition of ICIs that affect the tumor immune microenvironment. Moreover, in our multivariate cox regression analysis for OS, the significance between the high‐level and low‐level groups of NLR was not observed, compared to PFS. This implies that NLR could not be a suitable prognostic marker for ES‐SCLS patients who received first‐line ICIs. Zhao et al. recently reported that lower LMR level displayed a significantly poorer response rate to chemotherapy in patients with NSCLC receiving chemotherapy. In addition, in a large cohort study and a meta‐analysis, a higher LMR has been suggested to be linked to favorable prognosis in cases with lung cancer. , All the above results were consistent with our study. The precise mechanisms of the association remain uncertain, but several hypotheses have been proposed on this subject. It is well known that lymphocytes are essential for the antitumor immune response by triggering the death of the cytotoxic cell and inhibiting tumor growth. , In addition, by differentiating into tumor‐associated macrophages, monocytes could trigger genetic mutations, stimulate angiogenesis, and inhibit anti‐tumor immunity. , The importance of inflammatory biomarkers in the therapy of SCLC cases with chemo‐immunotherapy required more evidence. There were a few limitations to our research. First, as the study design is retrospective, propensity score matching could not completely exclude confounding variables and selective bias. Second, because of good performance status (PS = 0/1), the cases in our study could not represent the whole SCLC community. It is worth exploring whether patients with PS = 2 could benefit from chemo‐immunotherapy, and we look forward to future investigations. Third, the limited follow‐up period might have influenced the outcomes. Therefore, additional research including larger samples and longer follow‐ups is necessary. Last, the ideal cutoff value as a standard for these markers has not been determined; some investigators select the median value, whereas others based their decision on results from earlier studies. We use the ROC to choose the optimal cutoff.

In conclusion, our real‐world data demonstrated that ICIs plus EP as a first‐line setting for ES‐SCLC is effective and safe. Additionally, ECOG PS, liver metastases, and pretreatment inflammatory markers may serve as valuable prognostic factors for survival outcomes in ES‐SCLC cases that received first‐line ICIs plus chemotherapy, suggesting their potential prognostic value. Evaluation of biomarkers that could predict the prognosis of chemo‐immunotherapy in SCLC patients requires further research.

Jingyuan Xie: Conceptualization, data curation, formal analysis, investigation, methodology, project administration, software, validation, visualization, writing – original draft, writing – review and editing. Mo Chen: Conceptualization, data curation, formal analysis, investigation, methodology, project administration, writing – original draft, writing – review and editing. Hedong Han: Conceptualization, formal analysis, methodology, project administration, software, validation, visualization, writing – original draft. Ke Xu: Data curation, formal analysis, investigation, methodology. Guihuan Qiu: Investigation. Xinqing Lin: Project administration, resources, supervision. Yong Song: Conceptualization, funding acquisition, project administration, resources, supervision, validation, writing – review and editing. Jinjun Ye: Project administration, resources, supervision. Tangfeng Lv: Conceptualization, funding acquisition, project administration, supervision, writing – review and editing. Ping Zhan: Conceptualization, methodology, funding acquisition, writing – original draft, writing – review and editing.

This work was supported by grants from the 16th batch “Summit of the Six Top Talents” Program of Jiangsu Province (grant number WSN‐154); China Postdoctoral Science Foundation 12th batch Special fund (Postdoctoral number: 45786); China Postdoctoral Science Foundation 64th batch (Postdoctoral number: 45786); Jiangsu Provincial Postdoctoral Science Foundation (grant number 2018K049A); the Natural Science Foundation of Jiangsu province (grant number BK20180139); Jiangsu Provincial Health Committee Medical projects (grant number M2022110); Natural Science Foundation of Jiangsu Province (grant number BK20210146).

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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