Aneta Chylińska-Frątczak,Arkadiusz Michalak,Anna Baranowska-Jaźwiecka,Beata Mianowska,Agnieszka Szadkowska
Incidence of hyperglycaemic disorders in children and adolescents with obesity Stany hiperglikemiczne u dzieci i młodzieży z otyłością
obesity,hyperglycaemic disorders,OGTT,HbA1c,CGM,otyłość,zaburzenia hiperglikemiczne,OGTT,HbA1c,CGM
Introduction The prevalence of obesity in the paediatric population has increased significantly in recent decades. To date, the rarest metabolic disturbance associated with obesity has been the hyperglycaemia, including diabetes. The aim of the study was to compare the prevalence of hyperglycaemic disorders diagnosed on the basis of (1) the oral glucose tolerance test (OGTT) and (2) the HbA1c value, and to estimate the prevalence of hyperglycaemia in continuous glucose monitoring (CGM) records in adolescents with obesity. Material and methods The study included patients aged 9–18 years with obesity (BMI ≥ 95th percentile). The height, body weight, and waist circumference were measured, and the BMI and BMI Z-score were calculated. Sexual maturity was assessed on the Tanner scale. OGTT was performed, and the HbA1c value was measured. Six-day retrospective blinded CGM was performed. Results In the group of 143 children (mean age 13.4 years), the severity of obesity positively increased with patients age (r = 0.36 and p < 0.0001). Abdominal obesity was found in 93.4% of children. Based on OGTT, 18.8% of the subjects had hyperglycaemic disorders; impaired glucose tolerance was the most common one (16.1%). Impaired fasting glucose was found in 4 patients (2.8%), and type 2 diabetes was found in 2. The mean HbA1c was 5.4%. HbA1c values ranged from 5.7 to 6.4% in 20.3% of the patients, and it did not exceed 6.4% in any patient. In 27.6% of patients with HbA1c 5.7–6.4%, abnormalities in OGTT were observed (IGT 17.25%, IFG 6.9%, DM2 3.45%). There was a significant discrepancy between OGTT results and HbA1c in the diagnosis of hyperglycaemic disorders (diagnosis agreement – 69.92%). In CGM 1.4% of results were above 140 mg/dl. Conclusions Hyperglycaemic disorders are diagnosed in nearly 20% of children with obesity. However, there are significant discrepancies in the diagnosis of glucose disturbances using OGTT and HbA1c. Concordance in the diagnosis of hyperglycaemic disorders was achieved only in 70% of patients. CGM may be useful in the diagnosis of pre-diabetes in people with obesity.
Incidence of hyperglycaemic disorders in children and adolescents with obesity Stany hiperglikemiczne u dzieci i młodzieży z otyłością

The prevalence of obesity in the paediatric population has increased significantly in recent decades. To date, the rarest metabolic disturbance associated with obesity has been the hyperglycaemia, including diabetes.

was to compare the prevalence of hyperglycaemic disorders diagnosed on the basis of (1) the oral glucose tolerance test (OGTT) and (2) the HbA1c value, and to estimate the prevalence of hyperglycaemia in continuous glucose monitoring (CGM) records in adolescents with obesity.

The study included patients aged 9–18 years with obesity (BMI ≥ 95th percentile). The height, body weight, and waist circumference were measured, and the BMI and BMI Z-score were calculated. Sexual maturity was assessed on the Tanner scale. OGTT was performed, and the HbA1c value was measured. Six-day retrospective blinded CGM was performed.

In the group of 143 children (mean age 13.4 years), the severity of obesity positively increased with patients age (r = 0.36 and p < 0.0001). Abdominal obesity was found in 93.4% of children. Based on OGTT, 18.8% of the subjects had hyperglycaemic disorders; impaired glucose tolerance was the most common one (16.1%). Impaired fasting glucose was found in 4 patients (2.8%), and type 2 diabetes was found in 2. The mean HbA1c was 5.4%. HbA1c values ranged from 5.7 to 6.4% in 20.3% of the patients, and it did not exceed 6.4% in any patient. In 27.6% of patients with HbA1c 5.7–6.4%, abnormalities in OGTT were observed (IGT 17.25%, IFG 6.9%, DM2 3.45%). There was a significant discrepancy between OGTT results and HbA1c in the diagnosis of hyperglycaemic disorders (diagnosis agreement – 69.92%). In CGM 1.4% of results were above 140 mg/dl.

Hyperglycaemic disorders are diagnosed in nearly 20% of children with obesity. However, there are significant discrepancies in the diagnosis of glucose disturbances using OGTT and HbA1c. Concordance in the diagnosis of hyperglycaemic disorders was achieved only in 70% of patients. CGM may be useful in the diagnosis of pre-diabetes in people with obesity.

Obesity is a growing problem among children and adolescents worldwide. According to WHO data, currently 6% of girls and 8% of boys are obese (124 million in 2016), which is a dramatic increase compared to 1975, when the problem affected 1% of children. Over 340 million children and adolescents aged 5–19 were overweight or obese in 2016; 18% of girls and 19% of boys were overweight in 2016 [1]. In Poland, according to the OLAF study (PL0080) conducted in 2007–2009, more than 18% of boys and over 14% of girls were overweight; the prevalence of overweight or obesity by age and sex ranged from 9.1% of girls aged 16 years to 22.4% of boys aged 12 years [2]. The prevalence of obesity increased with age. Based on a study of Polish overweight and obese children aged 5–18 years, it was established that 36.6% of the patients were overweight or obese at the age of 2 years, 73.9% at the age of 4, and 84% at the age of 6 [3]. Excess body weight leads to lipid metabolism disorders, arterial hypertension, and hyperglycaemic disorders (diabetes or other abnormal glucose metabolism states, i.e. “prediabetes”, which, according to ADA, includes (1) impaired fasting glucose (IFG), (2) impaired glucose tolerance, IGT, and (3) increased HbA1c (5.7–6.4%) [4]. The coexistence of these disorders with obesity is referred to as metabolic syndrome, which is associated with more frequent development of atherosclerotic cardiovascular diseases [5]. The incidence of hyperglycaemic states is increasing worldwide [6] . In 2021 the International Diabetes Federation (IDF) estimated the global impaired glucose tolerance (IGT) prevalence at 10.6% and IFG prevalence at 6.2% – in both men and women. The majority of individuals with IGT reside in low-income countries (12.7%), lower- to middle- (10%), and high-income countries (10.4%). The prevalence of IFG in 2021 was similar across high-, middle-, and low-income countries (5.7–5.8%). The Western Pacific regions have the highest IGT prevalence (12.9%), and the South-East Asia region has the lowest prevalence (5.4%). South and Central America have the highest IFG prevalence (10%), and the Western Pacific has the lowest prevalence (2.5%) [7]. Until recently, hyperglycaemic conditions were least frequently diagnosed in Caucasian children. In the American population, among adolescents with overweight and obesity, dysglycaemia was diagnosed in 32.7% of obese children and in 23.6% of overweight children [8]. IDF projections indicate that by 2045 the number of adults with IGT will be 730 million worldwide, corresponding to 11.4% of the world’s adult population. IGT responding to 441 million adults and 6.9% of the global adult population [7]. The natural course of carbohydrate metabolism disorders depends on the degree of obesity, its duration, the amount of visceral adipose tissue, and positive family history. Initially, only insulin resistance is observed with compensating hyperinsulinaemia. Along with insulin secretion impairment, impaired glucose tolerance and/or impaired fasting glucose develops. The next stage is diabetes. According to the Diabetes Poland society, it is recommended that people be screened from risk groups for hyperglycaemic disorders because more than half of the people with diabetes have no symptoms of hyperglycaemia at the disease diagnosis. Regardless of age, screening should be performed in people at risk, including those who are obese [9]. Fasting blood glucose is the most commonly performed screening test, but this test cannot detect impaired glucose tolerance. For this reason, an oral glucose tolerance test (OGTT) is performed. According to the American Diabetes Association, hyperglycaemic disorders, including prediabetes, can be diagnosed based on HbA1c measurement [10]. The Diabetes Poland society has used the HbA1c-based criterion of diabetes diagnosis (HbA1c ≥ 6.5%) since 2021. Both OGTT and HbA1c are flawed in diagnosing hyperglycaemic disorders. Low reproducibility of results based on OGTT has been reported, and the HbA1c value reflecting average glycaemia over the past 3 months is affected by variability in erythrocyte formation and longevity, glycation disorders, haemoglobin disorders, and methods of HbA1c measurement. Lately, continuous glucose monitoring (CGM) systems have been considered useful in the diagnosis of hyperglycaemia disturbances. Currently, there are no criteria for diagnosing hyperglycaemic diseases on the basis of CGM results, although such research has been extensively carried out among cystic fibrosis patients [10]. Glucose metabolism disturbances present at the stage of prediabetes increase the risk of cardiovascular disease and reduce life expectancy [1, 11]. Younger patients are particularly at risk because their naturally expected lifespan is long. For this reason, hyperglycaemic disturbances should be sought for in high-risk children, including those with obesity [11]. The question arises whether both diagnostic methods (OGTT or HbA1c) similarly allow the diagnosis of the disorders. The aim of this study was to compare the prevalence of hyperglycaemic disorders diagnosed based on oral glucose tolerance test (OGTT) and by HbA1c, and to estimate the prevalence of hyperglycaemias in continuous glucose monitoring in adolescents with obesity.

The study protocol was approved by the Bioethics Committee at the Medical University of Lodz, No. RNN/224/15/KE. The study included patients with obesity hospitalized between 2013 and 2016 at the Department of Paediatrics, Endocrinology, Diabetology, and Nephrology, Central University Hospital in Lodz. Children aged 9–18 years, with BMI ≥ 95th percentile according to OLAF calculator http://olaf.czd.pl/, whose parents consented to their participation in the study were included. Patients with acute inflammatory disorders, concomitant chronic diseases, or secondary causes of obesity (genetic, endocrinopathy) were excluded. Medical examination with assessment of nutritional status (based on anthropometric measures) and puberty (according to the Tanner staging) was performed. The following anthropometric measurements were performed: height (with an accuracy of 0.5 cm), body weight (with an accuracy of 0.1 kg), and waist circumference (with an accuracy of 0.1 cm using a standard measuring tape). The obtained results were presented as absolute and percentile values. The body mass index (BMI) was calculated using the formula weight [kg]/height2 [m] and expressed as BMI z-score (obtained data were related to the current population reference values from the OLAF study [12]). A 2-hour OGTT was performed with assessment of blood glucose concentration at selected time points (0’, 15,’ 30’, 60’, 90’, and 120’). The HbA1c concentration was measured using high-performance liquid chromatography (HPLC) (Bio-Rad Laboratories GmbH, Munich, Germany). Blinded, 6-day continuous glucose monitoring (CGM) reports were recorded using an iPro CGM device (Medtronic MiniMed). Nominal variables were summarized as numbers and percentages (n, %) and compared between the groups with the c2 or Fisher’s test according to the sample size. Continuous characteristics were presented as means ± standard deviation. Distribution of continuous variables was assessed with the Shapiro-Wilk test. Afterwards, the comparisons between the groups were performed with t-tests for independent variables. Correlations were assessed using Pearson`s correlation coefficient following largely normal distributions of data. Concordance between OGTT results and HbA1c for detecting glucose tolerance abnormalities was measured with Cohen’s k. For all the tests, an a threshold of 0.05 was set for declaring significance. All calculations were performed using Statistica 13.1 (Tibco).

The study group included 151 patients with obesity. Eight individuals without current HbA1c values were excluded. The final analysis included 143 patients (65 girls and 78 boys) with a mean BMI of 30.4 kg/m2 and BMI Z-score of 2.2. Detailed characteristics of the group are presented in Table I. The severity of obesity (BMI z-score) positively increased with patients age (r = 0.36 and p < 0.0001). Girls presented higher sexual maturity than boys. The median of the Tanner stage for girls was 4 (25–75%: 2 to 5) and for boys it was 3 (25–75%: 2 to 4; p = 0.007) at similar ages (13.6 ±2.4 years vs. 13.3 ±2.6 years; p = 0.383). After adjusting for the Tanner stage, no differences in BMI z-score were observed between girls and boys (p = 0.110). Abdominal obesity was diagnosed in 93.4% of the patients. No difference was found between genders (92.3% for boys vs. 90.8% for girls, p = 0.741). Abnormal OGTT results were observed in 26 (18.8%) children; in 2 of them type 2 diabetes (DM2) was diagnosed (Table II). No abnormalities in OGTT were found in prepubertal patients. Both the DM2 patients were at Tanner stage 5. No statistically significant correlation was found between BMI Z-score and blood glucose level at any of the OGTT time points. There were no differences in the prevalence of hyperglycaemic disorders between genders – based on OGTT, 15 (19.2%) boys vs. 11 (16.9%) girls (p = 0.722). There was no significant difference in the incidence of hyperglycaemic disorders between patients with and without abdominal obesity. The mean HbA1c value was 5.4 ±0.3%. There was no correlation between HbA1c and BMI Z-score (r = 0.05, p = 0.549). In none of the patients HbA1c was > 6.5%. HbA1c in range 5.7 to 6.4% was found in 29 children (20,3%), with no difference in percentages between boys and girls; 16 (20.5%) vs. 13 (20%), respectively (p = 0.939). In 2 patients in whom DM2 was diagnosed based on OGTT, values of HbA1c were 6.2% and 5.1%. A significant discrepancy was demonstrated between OGTT and HbA1c results in diagnosing hyperglycaemic disorders. Among children with HbA1c between 5.7 and 6.4%, abnormal OGTT results were observed in 8 (27.6%) (including IGT in 5, IGT in 2, and type 2 diabetes in one patient). Concordant glycaemic states diagnosed based on both these tests were found in 99 patients (69.2%) (p < 0.001). Patients whose glycaemic status was classified differently based on OGTT vs. HbA1c (n = 43) did not differ significantly in terms of the analysed clinical parameters (Table III). Patients who were differently classified as suffering from hyperglycaemic states (n = 43) according to the OGTT and HbA1c criteria did not differ significantly in terms of the analysed clinical parameters (Table III). The CGM was performed in 46 patients who did not significantly differ from the other patients in terms of age, BMI Z-score, HbA1c, and the incidence of hyperglycaemic states (diagnosed according to HbA1c or OGTT). The mean glucose level in CGM records was 101.2 mg/dl, 98.5% of glucose readings ranged from 70 to 140 mg/dl, and 1% were over 140 mg/dl. Glucose values below 70 mg/dl constituted 0.5% of all the readings. The mean glucose level was 96.2 mg/dl at night (from midnight till 6 a.m.) and 102.9 mg/dl during the daytime. Fasting glucose levels significantly correlated with the CGM 24-h mean glucose levels (R = 0.27, p = 0.067), mean glucose levels at night (R = 0.43, p = 0.003), 24-h lowest glucose levels (R = 0.30, p = 0.046), the lowest glucose levels during the daytime (R = 0.30, p = 0.040), and lowest glucose levels at night (R = 0.37, p = 0.011). Blood glucose level at the 120’ OGTT timepoint significantly correlated with the CGM mean glucose level (R = 0.36, p = 0.015), the mean glucose level during the daytime (R = 0.40, p = 0.006), and the 24-h highest glucose level (R = 0.49, p = 0.001).Positive correlation was found between HbA1c values and mean CGM night-time glucose levels (R = 0.29, p = 0.046). Based on CGM analysis short episodes of glucose levels < 70 mg/dl during daytime were found in 14 children (30%), including values < 54 mg/dl in one patient. No abnormalities in OGTT were found in any of these patients, and 4 of them had HbA1c values between 5.7 and 6.4% (Supplementary Table I). Click here for additional data file. CGM values differed between patients with prediabetes (n = 5, IGT and/or IFG) and patients without hyperglycaemia at 0 min and 120 min of OGTT (n = 41) only in terms of mean glucose at night (102.2 mg/dl vs. 95.5 mg/dl, respectively; p = 0.032) and the lowest blood glucose detected over 24 h (80 mg/dl vs. 70.4 mg/dl, respectively; p = 0.040).

Based on our results, hyperglycaemic disorders were diagnosed based on OGTT in every fifth child with obesity. The OGTT is the principal diagnostic tool recommended by the WHO to diagnose hyperglycaemic disorders [13]. In our study group impaired glucose tolerance was the most commonly observed disturbance. Similar results were received by other researchers. In an Italian study carried out on 510 obese children aged 3–18 years, IGT was observed in 11.2% of the subjects (most often in adolescents – 14.8%) and type 2 diabetes in 2 teenagers (0.4%) [14]. In a Montenegrin population, IGT was diagnosed in 19.04% of obese patients and IFG in 4.76% [15]. Differences in IFG and IGT prevalence depend on race. A New Zealand review of studies found a higher prevalence of IFG in Caucasians, while both IGT and a combination of IFG and IGT were more common in Asian populations [16]. In a US study, IGT was found in 25% of obese children aged 4–10 years and in 21% of children aged 11–18 years. Type 2 diabetes was diagnosed in 4% of the subjects [17]. In a Polish study published in 2014, IGT was diagnosed in 4.5% of the 10-16-year-old group and in 3.8% of the group > 16 years of age. IFG was observed in 0.8% of subjects aged 10–16 years and in 1.9% of those aged > 16 years, while DM2 was diagnosed in 3 patients aged 10-16 years (2.3%) [5]. In this study IFG was diagnosed less frequently than IGT, which was also confirmed in the an US study quoted above (below 0.08%) and in Dutch research by Groot (IFG in 1.37% of the subjects) [17, 18]. That may be caused by the fact that usually, at the beginning, prandial impaired insulin secretion occurs, which is later followed by impaired basal insulin secretion. Hyperglycaemic disturbances in adolescents may be transitory, even in individuals with initial HbA1c values in the range diagnostic for diabetes (> 6.5%) [19]. According to the Diabetes Poland 2021 recommendations, the prediabetic state (IFG and/or IGT) is an indication for lifestyle modification, i.e. striving to achieve permanent body mass reduction, increasing physical activity, as well as considering metformin administration [9]. A study among 79 obese children with IGT demonstrated that in 66% of them glycaemia normalized at one-year follow-up with contributory factors being the following: lower body mass, lower HbA1c concentration, lower blood glucose values in a 2-hour OGTT test, as well as body mass reduction and later puberty over the follow-up period [20]. In the ADA recommendations, the highest efficacy in primary prevention was demonstrated in individuals with IGT with or without accompanying IFG rather than in those with isolated IFG or a prediabetic state defined according to HbA1c criteria [10]. Both puberty and pregnancy are probably critical periods in the development of hyperglycaemia disturbances in adolescents. At those times, increased tissue resistance to insulin occurs, leading to hyperinsulinaemia. Tissue sensitivity to insulin increases again after puberty. Thus, the type 2 diabetes peak coincides with sexual maturity Tanner stages 2–4 [21]. In our study, we found only 2 cases of type 2 diabetes concerning boys aged approximately 17 years at Tanner stage 5. The other cases of hyperglycaemic states diagnosed based on OGTT were observed in our study most commonly at Tanner stages 2 and 5; they were not diagnosed in children before puberty. OGTT requires appropriate patient preparation, fasting, staying in the laboratory/outpatient clinic for 2 hours, and at least 2 venous blood collections. Children sometimes vomit after drinking glucose solution used for OGTT, which necessitates the test to be discontinued and repeated another day. Therefore, it is quite difficult to monitor the majority of patients who are at risk for hyperglycaemic disorders, including children with obesity, with the use of OGTT. What is more, research results indicate rather low repeatability of OGTT results [22]. Thus, other diagnostic methods to identify hyperglycaemic disorders have been introduced. In 2010, the American Diabetes Association added HbA1c to diagnose hyperglycaemic disorders defining HbA1c 5.7–6.4% as prediabetes and HbA1c ≥ 6.5% as diabetes [23]. This parameter has gained increasing popularity in other countries too. In 2021 Diabetes Poland also included HbA1c ≥ 6.5% as a criterion to diagnose diabetes in its national recommendations [9]. As described by Herman and Fajans, there are several pros to use HbA1c to diagnose diabetes: 1) no need for the patient to be fasting before blood sample collection; 2) HbA1c concentration is much more stable than glucose concentration in a collected sample; 3) HbA1c determination is more repeatable than blood glucose measurement at 120 minutes in OGTT; and 4) HbA1c is not affected by sudden blood glucose fluctuations caused by stress or acute disease. However, the authors draw attention to limitations of the method, namely the impact of anaemia, hypertriglyceridaemia, and liver and kidney diseases on HbA1c concentration. Lower HbA1c concentrations typically occur in the course of those diseases. Hence, the authors propose joint application of HbA1c percentages and plasma glucose concentrations in diabetes diagnosis, particularly in individuals with comorbidities [24]. The latest ADA standards (2021) recommend screening tests for DM2 or prediabetes in asymptomatic children and adolescents after the onset of puberty or after 10 years of age (depending on which occurs earlier), who are overweight or obese, and have one or more additional DM2 risk factors. According to the ADA, fasting blood glucose, blood glucose at 120 minutes of OGTT, and HbA1c are equally appropriate as screening and diagnostic tests for both prediabetes and diabetes, in individuals at a seemingly low risk with a chance fasting glucose test, as well as in individuals with diabetes risk factors and asymptomatic patients [10]. It should be noted, however, that the tests do not necessarily detect diabetes in the same individuals. Love-Osborne demonstrated that the ease of HbA1c use may improve screening testing for type 2 diabetes among adolescents in primary healthcare [25]. We found significantly discordant results when using 2 diagnostic methods, OGTT and HbA1c. Concordant diagnoses were received in fewer than 70% of patients. A Korean study of 190 obese children confirmed DM in the OGTT study in 83.3% of people with HbA1c ≥ 6.5%. Conversely, 12.5% of people with DM diagnosed with OGTT had HbA1c < 6.5%. HbA1c levels of 6.15% have also been proposed as the optimal cut-off point for predicting diabetes in children [26]. In turn, a study by Chan it was shown that HbA1c and OGTT are equally useful screening tests for hyperglycaemia disturbances in obese adolescents [27]. A question arises of which prediabetes criterion will better stratify patients in terms of the diabetes development risk and long-term complications of hyperglycaemia [28]. The annual risk of diabetes in a person with IFG is almost 5 times higher than in an individual with normal glucose tolerance, whereas it is 6 times higher in a person with IGT. If IFG is accompanied by IGT, the annual risk of diabetes becomes 12 times as high as in healthy people [29]. According to US researchers, children with HbA1c values within prediabetes range (6.0–6.4%) are at a higher risk of type 2 diabetes development than those with HbA1c values of 5.7–5.9% [8]. Taking the discrepancies into account, other diagnostic methods may be considered. The continuous glucose monitoring (CGM) system is a relatively novel technology enabling frequent glucose measurements without the need to puncture the skin. Currently, parameters received on the basis of CGM have been approved by international experts for assessing glucose control in diabetic patients. A question arises of whether CGM may be more effective to recognize hyperglycaemic disorders in obese individuals compared to HbA1c and OGTT. The results of some studies indicate that CGM use in prediabetes diagnosis in high-risk groups, including adults and adolescents with obesity (especially with positive family history of type 2 diabetes), gestational diabetes, cystic fibrosis, polycystic ovary syndrome, acute coronary syndrome, and after kidney transplantation, is worth considering in diagnosing hyperglycaemia [30]. According to Finnish research, glucose levels measured in CGM and capillary glucose self-checks are useful in hyperglycaemia detection at the preclinical stage of type 1 diabetes. Elevated blood glucose levels at night are common in that group [31]. A group of Finnish and Italian researchers assessed CGM-based glycaemic variability indicators to show high accuracy in categorizing healthy and diabetic individuals, but slightly lower in dividing patients into groups with impaired glucose tolerance (IGT) and type 2 diabetes (DM2) [32]. Chan et al. proved that prediabetic individuals had considerably higher mean glucose levels, maximum glucose levels, areas under curve (AUC), and time spent in the range above glucose 140 mg/dl in CGM compared to adolescents with normal HbA1c or OGTT [27]. El Awwa et al. assessed 72-hour CGM, OGTT, HOMA, and QUICKY among 13 teenagers with obesity. OGTT revealed 3 cases (23%) of IFG, 4 cases (30%) of IGT, and no case of diabetes. When using CGM, IFG was detected in 4 cases, IGT in 9 cases, and diabetes in one subject. No hyperglycaemia was detected using HbA1c [33]. In our study only 1% of readings exceeded 140 mg/dl. Compared to subjects with normoglycaemia, in OGTT patients diagnosed as having prediabetes based on OGTT, CGM records showed only higher mean glucose levels at night, AUC at night, and the lowest glucose values over 24 hours compared to patients with normoglycaemia. But we should underline that our study and that of El Awwa included small numbers of subjects with CGM recordings, which is a limitation of both.

Hyperglycaemic disorders were diagnosed in almost 20% of children with obesity. Considerable discrepancies occurred in diagnosing hyperglycaemic states based on OGTT or HbA1c. Concordance in hyperglycaemic state diagnoses based on these 2 tools was confirmed in only 70% of patients. In the future, CGM may find a place in the diagnosis of pre-diabetes in people with obesity.