diff --git a/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/1Siama2xnE8_raw.srt b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/1Siama2xnE8_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..62075378e0bbc2f7beec9b50246b8f5b78c07e3a
--- /dev/null
+++ b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/1Siama2xnE8_raw.srt
@@ -0,0 +1,1856 @@
+1
+00:00:02,230 --> 00:00:06,690
+عوض بالله من الشيطان الرجيم بسم الله الرحمن الرحيم
+
+2
+00:00:06,690 --> 00:00:11,730
+الحمد لله وكفا و أصلب و أسلم على النبي المصطفى
+
+3
+00:00:11,730 --> 00:00:17,990
+أتشرف أن أبلغ معكم المحاضرة الأخيرة الثانية
+
+4
+00:00:17,990 --> 00:00:22,910
+والثلاثين في هذا المساق الشيق مساق الأحياء الدقيقة
+
+5
+00:00:22,910 --> 00:00:31,070
+لطلبة البصريات الطبيةالان هنتكلم عن باقي الفيروسات
+
+6
+00:00:31,070 --> 00:00:35,850
+اللتي تصيب العين هنتكلم اليوم عن 3 فيروسات أولها
+
+7
+00:00:35,850 --> 00:00:42,890
+german measel virus german measel الحصب الألماني
+
+8
+00:00:42,890 --> 00:00:47,660
+ربما كان اول اكتشافه في ألمانياانتشرت في البلاد
+
+9
+00:00:47,660 --> 00:00:53,960
+وهذا حقيقة الفيروس مهم في ناحية انه يصيب الحوامل
+
+10
+00:00:53,960 --> 00:01:01,080
+وقد يؤدي الى تدمير وقتل الجنين في بطن أمه او تشوهه
+
+11
+00:01:01,080 --> 00:01:07,680
+بعد الولادة وهنشوف احنا الفيروس مشهور باسم Rubella
+
+12
+00:01:07,680 --> 00:01:14,400
+ربما اللي اكتشفوا اسم Rubella في المانيافسموه
+
+13
+00:01:14,400 --> 00:01:17,740
+باسمه هو ال German Messenger الحصب الألماني لكن
+
+14
+00:01:17,740 --> 00:01:23,580
+مشهور باسم Rubella Rubella يعني اسم عالم مكتشف هو
+
+15
+00:01:23,580 --> 00:01:29,900
+Paramezovirus يختلف عن الفيروسات اللي أخدناها
+
+16
+00:01:29,900 --> 00:01:35,760
+بتاعة ال herpes و slow virus يعني slow virus يعني
+
+17
+00:01:35,760 --> 00:01:44,260
+فيروس يعني بطيء و يفتقد إلى ال activityيعني
+
+18
+00:01:44,260 --> 00:01:49,460
+ماعندهوش activity كافية زي باخر الفيروسات فهو يعني
+
+19
+00:01:49,460 --> 00:01:54,460
+مزمن يؤدي إلى مرض مزمن مش هاد زي باخر الفيروسات
+
+20
+00:01:54,460 --> 00:02:03,480
+وحنشوف احنا الفيروس بياخد شجور خلال سنين عشان يحدد
+
+21
+00:02:03,480 --> 00:02:09,820
+ال symptoms عشان يكون فيروسو لا يوجد اكتبتي في
+
+22
+00:02:09,820 --> 00:02:15,840
+النقل الحصبي أو الانتقال في جسم الإنسان السريع
+
+23
+00:02:15,840 --> 00:02:19,700
+الفيروس
+
+24
+00:02:19,700 --> 00:02:28,500
+كان نادر الحدوث في البلاد المتحدة الأمريكية خاصة
+
+25
+00:02:28,500 --> 00:02:36,680
+بعد سنة 1863 لما اكتشفوا اللي هو ال vaccineتطعيم
+
+26
+00:02:36,680 --> 00:02:44,880
+بتاعه حقيقة صار rare اه و قبلها كان طبعا اكتر لكن
+
+27
+00:02:44,880 --> 00:02:50,960
+بيسيب نوعين من الأطفال بيسيب الأطفال اللي ماتجوش
+
+28
+00:02:50,960 --> 00:02:56,700
+تطعيم بعد الولادة راح على المدرسة بدون ان يتطعم
+
+29
+00:02:56,700 --> 00:03:02,700
+فهذا ممكن ان يصيبه الفيروس او حتى شاب او شابة لم
+
+30
+00:03:02,700 --> 00:03:11,570
+يتلقى تطعيميبقى هو هذا اللي هو لم يأخذ التطعيم اه
+
+31
+00:03:11,570 --> 00:03:18,630
+في ال ELA هذا مينصاب رحت عليه يعني يعني هذا اتفضل
+
+32
+00:03:18,630 --> 00:03:22,370
+من غير تطعيم وبالتالي هذا عرض للإصابة والناس
+
+33
+00:03:22,370 --> 00:03:27,090
+التانين اللي هو الجنين في بطن أمه الجنين في بطن
+
+34
+00:03:27,090 --> 00:03:33,310
+أمه هؤلاء يعني ممكن ينصابواالناس الـ non-immunized
+
+35
+00:03:33,310 --> 00:03:39,910
+الذين لم يتم تطييبهم والأطفال اللي لم يتركوا
+
+36
+00:03:39,910 --> 00:03:48,850
+اللقاح بعد الولادة أو الجنين في بطنهم هذه الصورة
+
+37
+00:03:48,850 --> 00:03:52,650
+الميكروسكوبية تعت الهوريوبيلا فيروس او german
+
+38
+00:03:52,650 --> 00:03:59,510
+measles virus حبل نووي وبرّا الـ spikes هذه وبعدين
+
+39
+00:03:59,510 --> 00:04:05,850
+الـ nuclear capsuleأه شايفين و ال envelope الخارجي
+
+40
+00:04:05,850 --> 00:04:10,410
+الأخضر هذا envelope طب ايه في الناحية الوبائية و
+
+41
+00:04:10,410 --> 00:04:19,170
+الانتشار بتاعه اه اقول انه ال virus من سنة ستة الى
+
+42
+00:04:19,170 --> 00:04:24,830
+تسعة سنين بيعمل epidemic يعني بيكون وباء ممكن يعمل
+
+43
+00:04:24,830 --> 00:04:32,340
+وباء في الأطفال اهويتكاتر في الجهاز التنفسي للأسف
+
+44
+00:04:32,340 --> 00:04:39,060
+في الشعب الهوائية وفي الشعبات الهوائية وينتقل عبر
+
+45
+00:04:39,060 --> 00:04:44,260
+القطيرات التنفسية يعني اللي بتطلع من الأنف و الكحة
+
+46
+00:04:44,260 --> 00:04:48,980
+و العطاس روبلس اللي بتطلع من الناس و الفريق من
+
+47
+00:04:48,980 --> 00:04:58,040
+اللي هو الحرق و العومبقول ان ال 25% من نساء
+
+48
+00:04:58,040 --> 00:05:03,660
+الحوامل مشكانين مخلين تطيب قبل ذلك و هم عرضة ان
+
+49
+00:05:03,660 --> 00:05:10,100
+يصابوا اثناء الحمل و يعني يؤدي الى قتل او تشويه
+
+50
+00:05:10,100 --> 00:05:15,100
+الجنين ال
+
+51
+00:05:15,100 --> 00:05:21,040
+virus ممكن انه يتم استخراجه واستخلاصه
+
+52
+00:05:22,170 --> 00:05:26,630
+عدة سنين من المرضى بعد عدة سنين يعني هذا بيروس
+
+53
+00:05:26,630 --> 00:05:33,090
+مزمن هذا كمان روبيلا فيروس روبيلا فيروس روبيلا
+
+54
+00:05:33,090 --> 00:05:34,030
+فيروس روبيلا فيروس روبيلا فيروس روبيلا فيروس
+
+55
+00:05:34,030 --> 00:05:35,670
+روبيلا فيروس روبيلا فيروس روبيلا فيروس روبيلا
+
+56
+00:05:35,670 --> 00:05:38,530
+فيروس روبيلا فيروس روبيلا فيروس روبيلا فيروس
+
+57
+00:05:38,530 --> 00:05:39,850
+روبيلا فيروس روبيلا فيروس روبيلا فيروس روبيلا
+
+58
+00:05:39,850 --> 00:05:48,670
+فيروس روبيلا فيروس روبيلا
+
+59
+00:05:48,670 --> 00:05:53,460
+فيروسهو يجسم الـ Clinical Picture أصوات كليكية
+
+60
+00:05:53,460 --> 00:05:58,060
+التي تحتوي على العلماء والأعراض إلى نوعين الـ
+
+61
+00:05:58,060 --> 00:06:01,880
+General Clinical Picture و الـ Ocular Clinical
+
+62
+00:06:01,880 --> 00:06:06,120
+Picture احنا بنركز كتير على الـ Ocular Clinical
+
+63
+00:06:06,120 --> 00:06:13,940
+Picture الـ General Picture انه في الأضل ساخن في
+
+64
+00:06:13,940 --> 00:06:19,820
+بلش عند سخونة إذك يعني صدراء و ماليزي يعني عنده
+
+65
+00:06:19,820 --> 00:06:25,880
+إغياءماليز يعني إعياء بعد أيام من هذه السخونة
+
+66
+00:06:25,880 --> 00:06:32,100
+والإعياء بيبدأ طفح جلدي يطلع على جلده اسمه ماكيولو
+
+67
+00:06:32,100 --> 00:06:37,300
+popular rash الماكيولو يعني حبيبات صغيرة
+
+68
+00:06:37,300 --> 00:06:43,480
+والفابيولو حبيبات أكبر ماكيولو ماكيولو ماكيولو
+
+69
+00:06:43,480 --> 00:06:49,220
+ماكيولو ماكيولو
+
+70
+00:06:49,220 --> 00:06:49,960
+ماكيولو ماكيولو ماكيولو ماكيولو ماكيولو ماكيولو
+
+71
+00:06:49,960 --> 00:06:50,000
+ماكيولو ماكيولو ماكيولو ماكيولو ماكيولو ماكيولو
+
+72
+00:06:50,000 --> 00:06:50,000
+ماكيولو ماكيولو ماكيولو ماكيولو ماكيولو ماكيولو
+
+73
+00:06:50,000 --> 00:06:51,010
+ماكيولو ماكيولو ماكيولو ماكيولو ماكيولو ماكوعلى
+
+74
+00:06:51,010 --> 00:06:54,990
+الصدر وعلى بطنها ده اسمه trunk يعني مش على إيدي
+
+75
+00:06:54,990 --> 00:06:59,530
+ورجليك وبعدين تنتشر إلى ال extremities تنتشر إلى
+
+76
+00:06:59,530 --> 00:07:05,170
+اللي هو ال upper limb و ال lower limb و لهذه
+
+77
+00:07:05,170 --> 00:07:11,130
+الأعراض تنتشر
+
+78
+00:07:11,130 --> 00:07:20,710
+إلى الأعضاء ممكن في الدم عبر الدم طبعافي
+
+79
+00:07:20,710 --> 00:07:26,530
+Antibiotics اتشكلت دي اللي هو الفيروس عبر مهاجمة
+
+80
+00:07:26,530 --> 00:07:32,330
+ال lymphocytes له فممكن انه يعمل thrombocytopenic
+
+81
+00:07:32,330 --> 00:07:39,130
+pebra انه استقلال الدموية اللي في جسم المريض
+
+82
+00:07:39,130 --> 00:07:46,470
+يصيرها نوع من الاستهلاك ويعني يصير قليلا من ما
+
+83
+00:07:46,470 --> 00:07:52,150
+يودي الى نزيفThrombocytes يعني الصفائح الدموية
+
+84
+00:07:52,150 --> 00:07:58,450
+Platelets وPenic يعني قليل وPepra يعني نزيف نزيف
+
+85
+00:07:58,450 --> 00:08:02,650
+نتيجة انقلت عند الصفائح الدموية بفعل الفيروس اللي
+
+86
+00:08:02,650 --> 00:08:06,950
+هو Rubella أو German Maze وممكن تصير
+
+87
+00:08:06,950 --> 00:08:12,730
+lymphadenopathy تضخم في العقد اللينفاوية خاصة في
+
+88
+00:08:12,730 --> 00:08:20,100
+الرقبة وفي الحلق وSplenomegaly تضخم في الطحالممكن
+
+89
+00:08:20,100 --> 00:08:24,800
+في الحالات اللى وضع فيها صعب ومافيها مناعة كافية
+
+90
+00:08:24,800 --> 00:08:29,220
+انه يصل للمخ عبر الدم سيرقام الانتفاليتس انتقام
+
+91
+00:08:29,220 --> 00:08:36,040
+المخ و ال arthritis اللى هو المفاصل وممكن ال
+
+92
+00:08:36,040 --> 00:08:41,310
+hemorrhage يعني من الحلق او من عضاء اخرىممكن تصير
+
+93
+00:08:41,310 --> 00:08:45,370
+كاربايتس الفهاب في عضلة القلب loss of hearing يعني
+
+94
+00:08:45,370 --> 00:08:51,570
+تصير بسماعش وجينته يورانيالي infections او
+
+95
+00:08:51,570 --> 00:08:59,850
+disorders تصيبوا اضطرابات في اللي هو الجهاز البولي
+
+96
+00:08:59,850 --> 00:09:02,390
+الإخصابي
+
+97
+00:09:03,590 --> 00:09:08,010
+أو اللي هو ال gen-c لكن هذه الأضعمة في ال stations
+
+98
+00:09:08,010 --> 00:09:13,230
+جليلة جدا هذه rare يعني هذه الخمسة rare احنا شفنا
+
+99
+00:09:13,230 --> 00:09:17,710
+حقيقة مرضى حتى thrombocytopenic fever عنده جليل
+
+100
+00:09:17,710 --> 00:09:23,790
+لكن بسخر اه و بسيبه صداء اه و بسيبه اللي هو اعياء
+
+101
+00:09:23,790 --> 00:09:30,030
+اه و ال rush ضروري كلهم بسيب بسيبهم rush بعد هيك
+
+102
+00:09:30,030 --> 00:09:32,730
+جليل اللي بسيبه اللذيف هذا
+
+103
+00:09:36,940 --> 00:09:42,660
+هو الرقبة اه بيصير لكن هذا نادرا ما بيصير خاطئ
+
+104
+00:09:42,660 --> 00:09:48,640
+يعني الا في ناس عندهم نقص منعي طب دي جال العين ايش
+
+105
+00:09:48,640 --> 00:09:53,540
+الفيروس هذا بيعمل في العين بيعمل التهاب من تحماك
+
+106
+00:09:53,540 --> 00:09:59,100
+وdirectivitis التهاب القزحية iritis ممكن يعمل
+
+107
+00:09:59,100 --> 00:10:04,540
+superficial keratitis في الepitheliumof the
+
+108
+00:10:04,540 --> 00:10:09,900
+quernia ممكن يعمل paniobiates هذه طبعا نادرة جدا
+
+109
+00:10:09,900 --> 00:10:14,860
+paniobiates يعني في كل الممر النقودي اللي بتكون من
+
+110
+00:10:14,860 --> 00:10:20,020
+الائرز والسلريبودي والكرايز ممكن انه يعمل
+
+111
+00:10:20,020 --> 00:10:24,380
+exudative retinal detachment يعني exudative
+
+112
+00:10:24,380 --> 00:10:29,110
+النتيجة للرشورةالكثير من السوائل في الشبكية اللي
+
+113
+00:10:29,110 --> 00:10:33,170
+بعد هي بتصيرها fibrosis وscarring ممكن انه تعمل
+
+114
+00:10:33,170 --> 00:10:40,490
+detachment للشبكية لكن الحقيقة هو المشهور انه شفنا
+
+115
+00:10:40,490 --> 00:10:46,850
+عينيهم حمر اه القزحية بتاعتهم ممكن تلتهم و القرنية
+
+116
+00:10:46,850 --> 00:10:50,310
+ممكن تلتهم هنا ال detachment نادر جدا
+
+117
+00:10:50,310 --> 00:10:58,030
+والpneumovirus نادر جدايقول إنه أثناء الحامل لو
+
+118
+00:10:58,030 --> 00:11:05,770
+الحامل أصيبت بفيروس يعمل ميزا لروبيلا ممكن داخل
+
+119
+00:11:05,770 --> 00:11:10,850
+الرحم أن الجنين يتأثر خاصة إن أصابته في ال first
+
+120
+00:11:10,850 --> 00:11:15,990
+trimester إن أصابته في الثلث الأول من الحمل أول
+
+121
+00:11:15,990 --> 00:11:22,970
+تلت شهور من الحمل وممكن جدا يعني أنه أصيبه موت أو
+
+122
+00:11:22,970 --> 00:11:30,730
+أنهيعني تشوّر خطير ونشوف احنا هذا يعتمد على وقت ما
+
+123
+00:11:30,730 --> 00:11:37,270
+الأم أصابها الفيروس بقول عنه gestational age at
+
+124
+00:11:37,270 --> 00:11:43,270
+the time of virus exposure يعني متى تعرض الجنين أو
+
+125
+00:11:43,270 --> 00:11:47,490
+الأم تعرضت للفيروس في أي وقت من الحمل هل في الشهر
+
+126
+00:11:47,490 --> 00:11:51,230
+الأول أو التاني أو التالت أو بعد ذلك وحنشوف احنا
+
+127
+00:11:51,940 --> 00:11:56,180
+بيقول انه في ال early pregnancy يعني خاصة في الشهر
+
+128
+00:11:56,180 --> 00:12:01,640
+الأول او التاني ممكن ينزل ثقت اللي هو abortion
+
+129
+00:12:01,640 --> 00:12:07,900
+يعني اللي لا يكتمل الحمل السير ثقت الثقت هذا بيقول
+
+130
+00:12:07,900 --> 00:12:12,160
+عنه abortion في
+
+131
+00:12:12,160 --> 00:12:16,680
+ال first trimester يعني مثلا خلال أول ثلاث شهور
+
+132
+00:12:16,680 --> 00:12:20,980
+هانا early يعني مثلا في الأيام الأول أو الأسبوع
+
+133
+00:12:20,980 --> 00:12:27,000
+الأوللكن مثلا في أول تلت شهور شهر تاني او تالت
+
+134
+00:12:27,000 --> 00:12:31,520
+ممكن يصير له syndrome اسمه congenital rubella
+
+135
+00:12:31,520 --> 00:12:39,840
+syndrome CRSC congenital rubella syndrome ايش
+
+136
+00:12:39,840 --> 00:12:45,420
+المولود لما يولد مش ميت عايش لكن هتشوفوا ايش الفرق
+
+137
+00:12:45,420 --> 00:12:50,280
+بينه و بين الموتهتلاقي deaf يعني في deafness يعني
+
+138
+00:12:50,280 --> 00:12:57,680
+أطرش أصمت blind يعني أعمى heart malformation فيه
+
+139
+00:12:57,680 --> 00:13:02,220
+اتشوهات في القلب في الصممات في الحجر بتاعة القلب و
+
+140
+00:13:02,220 --> 00:13:10,460
+micro microcephalus يعني الرأس صغيرة الجمجمة صغيرة
+
+141
+00:13:10,460 --> 00:13:15,300
+وهذه خطيرة في أنه لا تسمح للبخ أن ينمو
+
+142
+00:13:18,540 --> 00:13:25,080
+هو microcephalus يعني رأسه رأس صغيرة وهذا يهدد نمو
+
+143
+00:13:25,080 --> 00:13:30,880
+المخ في السنوات الأول من الحياة يبقى ال syndrome
+
+144
+00:13:30,880 --> 00:13:35,200
+هذا priobella syndrome مهم جدا وكثير يعني بتعامل
+
+145
+00:13:35,200 --> 00:13:42,860
+فيه دراسة انه deaf و blind و heart malformation و
+
+146
+00:13:42,860 --> 00:13:44,340
+microcephalus
+
+147
+00:13:47,310 --> 00:13:52,270
+هذا صورة للمولود congenital
+
+148
+00:13:52,270 --> 00:13:59,030
+rubella syndrome hard disease مراد في القلب خاصة
+
+149
+00:13:59,030 --> 00:14:05,270
+في الصنمات القلبية microcephaly يعني رأس الكون
+
+150
+00:14:05,270 --> 00:14:14,930
+صغيرة و عنده PTK و perprah يعني نزيف صغيرptk نظيف
+
+151
+00:14:14,930 --> 00:14:19,790
+كبير نظيف صغير نظيف كبير نظيف كبير نظيف كبير نظيف
+
+152
+00:14:19,790 --> 00:14:26,890
+كبير نظيف كبير نظيف كبير نظيف كبير نظيف كبير نظيف
+
+153
+00:14:26,890 --> 00:14:30,310
+كبير نظيف كبير نظيف كبير نظيف كبير نظيف كبير نظيف
+
+154
+00:14:30,310 --> 00:14:31,170
+كبير نظيف كبير نظيف كبير نظيف كبير نظيف كبير نظيف
+
+155
+00:14:31,170 --> 00:14:31,210
+كبير نظيف كبير نظيف كبير نظيف كبير نظيف كبير نظيف
+
+156
+00:14:31,210 --> 00:14:37,670
+كبير نظيف كبير نظيف كبير نظيف
+
+157
+00:14:37,670 --> 00:14:39,930
+كبير نظيف كبير نظيف كبير نظيف كبير نظيف كبير نظيف
+
+158
+00:14:39,930 --> 00:14:43,980
+كبير نظيف كبير نظيف كبير نظيف كبيرفي الشهر الأول
+
+159
+00:14:43,980 --> 00:14:50,740
+او السلسة الأول او السلسة الأول او السلسة الأول او
+
+160
+00:14:50,740 --> 00:14:52,280
+السلسة الأول او السلسة الأول او السلسة الأول او
+
+161
+00:14:52,280 --> 00:14:55,380
+السلسة الأول او السلسة الأول او السلسة الأول او
+
+162
+00:14:55,380 --> 00:14:56,340
+السلسة الأول او السلسة الأول او السلسة الأول او
+
+163
+00:14:56,340 --> 00:14:56,920
+السلسة الأول او السلسة الأول او السلسة الأول او
+
+164
+00:14:56,920 --> 00:14:57,340
+السلسة الأول او السلسة الأول او السلسة الأول او
+
+165
+00:14:57,340 --> 00:15:01,620
+السلسة الأول او السلسة الأول او السلسة الأول او
+
+166
+00:15:01,620 --> 00:15:02,580
+السلسة الأول او السلسة الأول او السلسة الأول او
+
+167
+00:15:02,580 --> 00:15:09,560
+السلسة الأول او السلسة الأول او السلسة الأول او
+
+168
+00:15:14,020 --> 00:15:24,320
+glucoma اللي بيقول عنه بو فثالمث بو بو فثالمث
+
+169
+00:15:24,320 --> 00:15:34,760
+فثالمث
+
+170
+00:15:34,760 --> 00:15:42,020
+بو فثالمث congenital glucoma بيو
+
+171
+00:15:43,230 --> 00:15:52,690
+P-H-A-T-H-P-H
+
+172
+00:15:52,690 --> 00:15:52,810
+-P-H-A-T-H-P-H-P-H-P-H-P-H-P-H-P-H-P-H-P-H-P-H-P-H
+
+173
+00:15:52,810 --> 00:15:52,990
+-P-H-P-H-P-H-P-H-P-H-P-H-P-H-P-H-P-H-P-H-P-H-P-H-P
+
+174
+00:15:52,990 --> 00:15:54,830
+-H-P-H-P-H-P-H-P-H-P-H-P-H-P-H-P-H-P-H-P-H-P-H-P-H
+
+175
+00:15:54,830 --> 00:16:00,490
+-P-H-P-H-P-H-P-H-P-H-P-H-P-H-P-H
+
+176
+00:16:00,490 --> 00:16:05,450
+-P-H-P-H-P-H-P-H-P-H
+
+177
+00:16:05,450 --> 00:16:08,470
+-P
+
+178
+00:16:08,470 --> 00:16:18,600
+-H-P-H-Konic clouding يعني الكورنيا عالية مش ماشي
+
+179
+00:16:18,600 --> 00:16:25,360
+أكلير Transparent عيرس أتروفي ممكن يصير فيه دموع
+
+180
+00:16:25,360 --> 00:16:29,760
+في بعض مناطق اللي هو العيرس ممكن بعضهم عيرايتس
+
+181
+00:16:29,760 --> 00:16:35,580
+التهاب العيرس كوريو ريتينايتس التهاب مش بس العيرس
+
+182
+00:16:35,580 --> 00:16:42,880
+بل البرويل و ريتنا و أبطك أتروفي كل هذافي عين
+
+183
+00:16:42,880 --> 00:16:46,940
+الموجودة اللى أصابه الفيروس في الثلوج الأول من
+
+184
+00:16:46,940 --> 00:16:51,460
+الحمل لو
+
+185
+00:16:51,460 --> 00:16:57,280
+جبنا كاميرا لقايا العين فاندس كاميرا اسمها
+
+186
+00:16:57,280 --> 00:17:04,240
+photograph تعمل لنا مولود عنده كنية الريوبيلا طبعا
+
+187
+00:17:04,240 --> 00:17:09,160
+بعد أسابيع من ولاته هنلاقي شيء اسمه salt and
+
+188
+00:17:09,160 --> 00:17:14,880
+pepper فاندسSalt and pepper fondas في مناطق في
+
+189
+00:17:14,880 --> 00:17:18,900
+شبكية hyper pigmented وفي مناطق hypo pigmented
+
+190
+00:17:18,900 --> 00:17:24,420
+hypo و hyper pigmented Salt and pepper fondas و
+
+191
+00:17:24,420 --> 00:17:27,860
+هذا salt and pepper fondas بيقول عنه زي الفلفل
+
+192
+00:17:27,860 --> 00:17:35,700
+الأصمر مع الملح لما احنا بنفط في طبق شوية ملح مع
+
+193
+00:17:35,700 --> 00:17:41,280
+فلفل أصمر بيكون اشي أبيض و اشي أسود وهذا طبعايعني
+
+194
+00:17:41,280 --> 00:17:47,040
+مش معهود في ال normal فاندس يعني اللي عمل هيك هو
+
+195
+00:17:47,040 --> 00:17:52,280
+ال virus بتاع ريو ميلا ال virus بتاع ريو ميلا
+
+196
+00:17:52,280 --> 00:17:57,940
+بيقول ان هذا ال sort and paper فاندس سيما لهذا
+
+197
+00:17:57,940 --> 00:18:04,080
+المخلوق طوله عيش خلاص يعني متغيرش مهما كان الوضع
+
+198
+00:18:04,080 --> 00:18:12,770
+طيب لو أصابواوقلنا تلات حاجات لو أصابه في أول حمل
+
+199
+00:18:12,770 --> 00:18:17,910
+أول أول مثلا أول أسبوعين تلاتة هيعمل abortion مات
+
+200
+00:18:17,910 --> 00:18:22,830
+لو صابه في first trimester في أول تلات شهور ممكن
+
+201
+00:18:22,830 --> 00:18:28,130
+يعمله ال syndrome طب لو صابه في trimester الثاني
+
+202
+00:18:28,130 --> 00:18:32,190
+أو الثالث يعني من تلاتة إلى ست شهور أمصي الشهور
+
+203
+00:18:32,190 --> 00:18:37,110
+إلى تسعة شهور يعني نقول من أربعة إلى ستة
+
+204
+00:18:40,040 --> 00:18:48,340
+تسعة تسعة بقول لي يعني ممكن يكون no harm او little
+
+205
+00:18:48,340 --> 00:18:53,580
+harm no harm او little harm على اللي هو الجنين
+
+206
+00:18:53,580 --> 00:18:58,140
+خلصنا احنا الان Europella virus بس انا هقول يعني
+
+207
+00:18:58,140 --> 00:19:02,280
+طرفا الطرف اللي اتعلمناها زمان انه يعني كانوا في
+
+208
+00:19:02,280 --> 00:19:10,360
+بلاد اوروبا لما شابهغير متزوجة يعني تنصاب بالفيروس
+
+209
+00:19:10,360 --> 00:19:15,980
+كانت تعمل party حفلة وتدعو الها زميلاتها في
+
+210
+00:19:15,980 --> 00:19:20,580
+الجامعة مثلا او في الثانوية وفي ال party هذه يعني
+
+211
+00:19:20,580 --> 00:19:30,500
+اتبادلوا اللي هو يعني قبلات وكلام عشان ياخدوا منها
+
+212
+00:19:30,500 --> 00:19:36,020
+الفيروس حتى لما يتزوجوا لو أصيبوا بالفيروس يكونوا
+
+213
+00:19:36,020 --> 00:19:40,710
+عندهم مناعةيعني هما أخذوا الفيروس و هي بنت مش من
+
+214
+00:19:40,710 --> 00:19:46,670
+زوجة فاستفادت في يعني استفادوا اللي يعني عملت
+
+215
+00:19:46,670 --> 00:19:52,070
+معاهم الحفلة انه أخذوا الفيروس فتى انه ماينصبوش في
+
+216
+00:19:52,070 --> 00:19:56,070
+بعد الزواج و يصير لهم الريوبلا syndrome للجنين
+
+217
+00:19:56,070 --> 00:20:00,450
+بتاعهم طبعا الان احنا في الحمد لله في أول سنين من
+
+218
+00:20:00,450 --> 00:20:05,290
+العمر أول سنتين تلاتة بصير قاطعين بهذا الفيروسوجال
+
+219
+00:20:05,290 --> 00:20:08,390
+كثير في العالم اللي هو German measles نتيجة
+
+220
+00:20:08,390 --> 00:20:12,390
+للتطعيم و بخي تصيب بعض الناس اللي لم ياخدوا هذا
+
+221
+00:20:12,390 --> 00:20:17,950
+اللي هو التطعيم الفيروس اللي قبل الأخير فيروس
+
+222
+00:20:17,950 --> 00:20:22,890
+الحصبة وهذه الحصبة لها سجون كانت زمان تقتل يعني
+
+223
+00:20:22,890 --> 00:20:28,710
+أقل اشي 20-30% من الأطفال عبر العالم فيروس الحصبة
+
+224
+00:20:28,710 --> 00:20:33,270
+فيروس الحصبة Paramyzovirus
+
+225
+00:20:33,830 --> 00:20:42,370
+وهو single strand RNA من فصيلة ال paramezoviruses
+
+226
+00:20:42,370 --> 00:20:45,770
+مافيش
+
+227
+00:20:45,770 --> 00:20:49,130
+إله عائل إلا الإنسان بس لا يعيش في الحيوانات أو
+
+228
+00:20:49,130 --> 00:20:54,950
+الفئران أو الغنم أو أوخنازير بس فيه الإنسان مافيش
+
+229
+00:20:54,950 --> 00:21:01,250
+animal reservoir إلا وغير الإنسان ال virus يعني هو
+
+230
+00:21:01,250 --> 00:21:06,510
+أيضا virus تنفسي بيجي في ال nasopharynx في الحلق و
+
+231
+00:21:06,510 --> 00:21:11,630
+في البلعوم و الحنجرة و الرداد اللي بيطلع في العطس
+
+232
+00:21:11,630 --> 00:21:16,680
+أو الكحة ممكن يكون حامل ال virusواللي هو منادير
+
+233
+00:21:16,680 --> 00:21:20,820
+المريض وملابس المريض اللي وجه عليها يعني اللي هو
+
+234
+00:21:20,820 --> 00:21:25,240
+ال secretions بتاعته أيضا حاملة لل فيروس يعني لو
+
+235
+00:21:25,240 --> 00:21:32,410
+واحد يعني طفل كح على طفل عادي وهذا كالأول مريضممكن
+
+236
+00:21:32,410 --> 00:21:38,530
+انه airborne الروداد هذا يصيبه صليم و يصاب و لو
+
+237
+00:21:38,530 --> 00:21:42,490
+اللي هو منافسة المريض او منادي المريض واحد
+
+238
+00:21:42,490 --> 00:21:46,150
+استعملها مباشرة على القلب او الحقر ممكن الويروس
+
+239
+00:21:46,150 --> 00:21:51,270
+يخش و يسكتر ذاته طيب هذا الويروس single strand RNA
+
+240
+00:21:51,270 --> 00:22:00,270
+Paramezovirus اللي هو بتاع الحصبة طيب لما الحصبة
+
+241
+00:22:00,270 --> 00:22:06,860
+كانت بتصيب الطفلهو بصيب الكبير بصير fever سخونة و
+
+242
+00:22:06,860 --> 00:22:12,320
+كف و كحة و كورايزة رشح كورايزة يعني معناها running
+
+243
+00:22:12,320 --> 00:22:18,500
+nose جريان الأنف بالإفرازات و بتبدأ العين تصيب a
+
+244
+00:22:18,500 --> 00:22:25,680
+chronic survivor تستحمل بعد هيك ببدأ السخونة انها
+
+245
+00:22:25,680 --> 00:22:32,320
+تطلع لمدة أسبوع بعدين ببدأ طفل حلو ديوشوفنا احنا
+
+246
+00:22:32,320 --> 00:22:37,840
+ال rush قبل هيك لجمع ال meses ال rush هذا عكس اللي
+
+247
+00:22:37,840 --> 00:22:44,700
+هو الأولاني هذا بيجي على ال اس و بيجي على الجبهة و
+
+248
+00:22:44,700 --> 00:22:49,640
+بيجي على الرقبة و بعدين بيز الأخرى اللي بقول ايه
+
+249
+00:22:49,640 --> 00:22:51,160
+centrifugal
+
+250
+00:22:53,810 --> 00:22:57,310
+Centrifugal يعني هو بيجي من الأطراف و بروح على
+
+251
+00:22:57,310 --> 00:23:03,010
+المركز عكسها ده كاللي ببدأ في المركز اللي هو جم
+
+252
+00:23:03,010 --> 00:23:06,590
+الميزز و بروح على الأطراف وهذه يعني ملفوظة مهمة
+
+253
+00:23:06,590 --> 00:23:11,170
+يعني في التشخيص يعني لو جينا احنا الطفل او الكبير
+
+254
+00:23:11,170 --> 00:23:14,850
+يعني بدأ معاه في ال trunk بكون جم الميزز لو بدأ
+
+255
+00:23:14,850 --> 00:23:19,590
+معاه في الأطراف خاصة الرقبة والدنين والوجه زي
+
+256
+00:23:19,590 --> 00:23:23,390
+الشكل هذا اللي هوريكوا إياه هيهشايفين وش وكيف مرش
+
+257
+00:23:23,390 --> 00:23:29,870
+ومرشم هذا ميجز دي اما ميجز بتبدأش في الولحة بتبدأ
+
+258
+00:23:29,870 --> 00:23:36,690
+في ال trunk بعد هيك لما طلع الراش فتحت ام الولد
+
+259
+00:23:36,690 --> 00:23:43,390
+لجينا شي اسمه complex spots وهو spots وهدي شي عجيب
+
+260
+00:23:43,390 --> 00:23:49,930
+يعني هي دائرة زرقاء مغطاة
+
+261
+00:23:49,930 --> 00:23:58,190
+ب اللي هوب اللون الأزرق وموجودة في الموت من قسم
+
+262
+00:23:58,190 --> 00:24:02,710
+البرن يعني لازم يفتح تمه لازم يفتح تمه بقعد هيك
+
+263
+00:24:02,710 --> 00:24:07,110
+ونشوف الدائرة الزرقاء او البنفسلية الدائرة الزرقاء
+
+264
+00:24:07,110 --> 00:24:13,430
+او البنفسلية كنا نسمع من أطباء الأطفال ان ال
+
+265
+00:24:13,430 --> 00:24:17,350
+complex sign pathognomonic هذا التشخيص
+
+266
+00:24:17,350 --> 00:24:26,570
+pathognomonic للميززليه ال mases ال rush بعد أيام
+
+267
+00:24:26,570 --> 00:24:32,190
+يختفي ويصبح بني بدل ما هو أحمر بيقولوا عنه فرق
+
+268
+00:24:32,190 --> 00:24:37,370
+يعني خلاص بدأ يكتفي سلون وفاتح هذا ال phenomenon
+
+269
+00:24:37,370 --> 00:24:42,610
+طيب ايش ال ocular احنا متعنى بال ocular ايش الحصبة
+
+270
+00:24:42,610 --> 00:24:49,470
+بتعمل في اللي هو المريض الحصبة
+
+271
+00:24:50,280 --> 00:24:55,500
+بتعمل في عين المريض conractivitis بتعمل keratitis
+
+272
+00:24:55,500 --> 00:25:06,700
+اتهاب المتحمة و اتهاب الخنانية اه بعد سبوع او
+
+273
+00:25:06,700 --> 00:25:11,860
+اتنين من بداية العدوى الحصبة بعد ما يطلع على الرأس
+
+274
+00:25:11,860 --> 00:25:20,220
+و ال complex بيبدأ يروح العين طيب الانالفيروس بيهد
+
+275
+00:25:20,220 --> 00:25:25,300
+المناعة بتاعك الطفل خاصة في السنة الأولى من السن
+
+276
+00:25:25,300 --> 00:25:30,260
+وبالتالي تبدأ البكتيريا TE وهي البكتيريا موجودة
+
+277
+00:25:30,260 --> 00:25:34,520
+أساسا بس بتكون opportunistic يعني اتهاجية وممكن
+
+278
+00:25:34,520 --> 00:25:37,760
+تعمله blindness في العين البكتيريا مضاعفات يعني
+
+279
+00:25:37,760 --> 00:25:42,660
+طيب زي ايش مضاعفات كون ال illusion عبارة عن تقرحات
+
+280
+00:25:42,660 --> 00:25:48,420
+قرنية وهذه من أهم أسباب العمىلبعض الأطفال يبقى هي
+
+281
+00:25:48,420 --> 00:25:51,480
+major cause of blindness في developing countries
+
+282
+00:25:51,480 --> 00:25:54,900
+في الدول النامية اللى هو الكيراكايتس فيه ايش
+
+283
+00:25:54,900 --> 00:25:59,440
+الكيراكايتس ممكن لو ضيقة المرأة اكتر عند هذا الطفل
+
+284
+00:25:59,440 --> 00:26:04,840
+تعمل ريتنايتس التهاب في اللى هو الشبكية و تعمله
+
+285
+00:26:04,840 --> 00:26:10,640
+macular edema عبارة عن تورم في مركز الشبكية هو
+
+286
+00:26:10,640 --> 00:26:15,860
+الشبكية start formation اللى هو يعني نوع مناللي هو
+
+287
+00:26:15,860 --> 00:26:22,700
+ال اكسيو ديات النجمي على اللي هو الإديمة وهي طبعا
+
+288
+00:26:22,700 --> 00:26:30,880
+خطيرة ممكن ال optic disc يصير swollen إديمة و ممكن
+
+289
+00:26:30,880 --> 00:26:35,180
+يصير neuroletonitis بس هذا طبعا جديد بيصير يعني
+
+290
+00:26:35,180 --> 00:26:38,140
+هذه ال macular edema و ال star formation و الكلام
+
+291
+00:26:38,140 --> 00:26:43,160
+هذا جديد بيصيربقول لي ممكن اكتر من مؤسسة Oblique
+
+292
+00:26:43,160 --> 00:26:47,840
+Neuritis اتهاب العصب البصري Corneolitis و Corneal
+
+293
+00:26:47,840 --> 00:26:51,240
+Ulceration و Percolation هذه نادر مابتصير يبقى
+
+294
+00:26:51,240 --> 00:26:56,260
+نمرأ اربعة و خمسة نادرة جدا في الأطفال اللي يكون
+
+295
+00:26:56,260 --> 00:27:00,520
+بناعتهم صفر انما ال Corneal Ulceration اه و
+
+296
+00:27:00,520 --> 00:27:05,340
+Corneolactovitis و Keratitis اه اه هذه بتصير و
+
+297
+00:27:05,340 --> 00:27:09,560
+ممكن تصلي العمى لكن Corneolitisوالكنيوريتنايتس و
+
+298
+00:27:09,560 --> 00:27:15,780
+الابتكنوريتس و الكنيوريتنايتس و الابتكنوريتس و
+
+299
+00:27:15,780 --> 00:27:21,700
+الكنيوريتنايتس و الابتكنوريتس و الكنيوريتنايتس و
+
+300
+00:27:21,700 --> 00:27:22,280
+الابتكنوريتس و الكنيوريتنايتس و الكنيوريتنايتس و
+
+301
+00:27:22,280 --> 00:27:23,060
+الكنيوريتنايتس و الكنيوريتنايتس و الكنيوريتنايتس و
+
+302
+00:27:23,060 --> 00:27:24,860
+الكنيوريتنايتس و الكنيوريتنايتس و الكنيوريتنايتس و
+
+303
+00:27:24,860 --> 00:27:29,260
+الكنيوريتنايتس و الكنيوريتنايتس و الكنيوريتنايتس و
+
+304
+00:27:29,260 --> 00:27:30,100
+الكنيوريتنايتس و الكنيوريتنايتس و الكنيوريتنايتس و
+
+305
+00:27:30,100 --> 00:27:36,900
+الكنيوريتنايتس و الكنيوريتنايتس و الكنيوريتنايتس
+
+306
+00:27:36,900 --> 00:27:51,930
+و الكنD S D S A A acquired I
+
+307
+00:27:51,930 --> 00:28:01,210
+immuno D deficiency A syndrome متلازمة اللي هو نقص
+
+308
+00:28:01,210 --> 00:28:07,420
+المناع المكتسبة acquired immunodeficiency syndrome
+
+309
+00:28:07,420 --> 00:28:13,920
+الفيروس اللى بيعملها اسمه hiv human human
+
+310
+00:28:13,920 --> 00:28:20,380
+deficiency virus حقيقة ان هذا الفيروس هو single
+
+311
+00:28:20,380 --> 00:28:25,380
+strand RNA حجمه
+
+312
+00:28:25,380 --> 00:28:34,630
+80 الى 140 نانو متركون شبه كمعي ممكن
+
+313
+00:28:34,630 --> 00:28:38,290
+نشوفه من مجلسكوب الاكتروني عبر صبغات محددة
+
+314
+00:28:38,290 --> 00:28:44,070
+للفيروسات الواس باكس صغيرة يعني ماتبينش كويس اللي
+
+315
+00:28:44,070 --> 00:28:49,390
+هو الأشواك الخارجية هشوفه الآن وهذا لما يخش في
+
+316
+00:28:49,390 --> 00:28:55,270
+الإنسانخاصة عن طريق العدات الذنسية اللي هي الخاطئة
+
+317
+00:28:55,270 --> 00:29:00,330
+ممكن انه يدخل في الـcytoplasm للمريض اللي انصاب
+
+318
+00:29:00,330 --> 00:29:09,710
+وانه يبدأ يتكاثر في الـcytoplasm داخل الخلايا هذه
+
+319
+00:29:09,710 --> 00:29:17,050
+يعني مختصر مفيد لل main symptoms of AIDS الأعراض
+
+320
+00:29:17,050 --> 00:29:24,190
+الكبرىليه اللي هو نقص المناع المكتسبة في المخ
+
+321
+00:29:24,190 --> 00:29:29,230
+بيعمل central encephalitis و meningitis في ال eye
+
+322
+00:29:29,230 --> 00:29:37,010
+بيعمل tenitis في ال lung بيعمل pneumonia و بيعمل
+
+323
+00:29:37,010 --> 00:29:43,130
+pneumocystitis و tuberculosis و potumals pneumonia
+
+324
+00:29:43,130 --> 00:29:47,670
+انتهاب رئوي pneumocystitis انتهاب في الحواصلات
+
+325
+00:29:47,670 --> 00:29:54,280
+الهوائيةأه تباركوا لوزيس اللي هو celery أوى و
+
+326
+00:29:54,280 --> 00:30:00,240
+tumors أو رعمه في skin هيو بيعمل tumors اللي بيقول
+
+327
+00:30:00,240 --> 00:30:04,620
+عنه skin sarcoma و هتشوفها skin sarcoma
+
+328
+00:30:06,870 --> 00:30:12,530
+في الجهاز الهضمى بيعمل Esophagitis Esophagitis
+
+329
+00:30:12,530 --> 00:30:17,150
+اللى هو الذهاب المريق وكونه دياريا دياريا يعني
+
+330
+00:30:17,150 --> 00:30:24,150
+اللى هو اسهال مزمن و tumors اللى هو أورام في
+
+331
+00:30:24,150 --> 00:30:31,170
+الجهاز الهضمى هذه صورة مكبرة كتير للفيروس كيف
+
+332
+00:30:31,170 --> 00:30:38,000
+الحبل النووي بتاعه وكيف ال spikesالانفلوب بتاعه هو
+
+333
+00:30:38,000 --> 00:30:44,480
+نيكليو كابسيد A اللي هو داخله طيب هاي skin sarcoma
+
+334
+00:30:44,480 --> 00:30:48,620
+هذه نوع من السرطان نوع من السرطان هي في lower lid
+
+335
+00:30:48,620 --> 00:30:57,480
+of this eye برضه هذا sarcoma هي منتشرة في جلد هذا
+
+336
+00:30:57,480 --> 00:31:01,480
+المريض طيب ايه بدي ميوريجي؟ نشوف نواعي الوابعية
+
+337
+00:31:05,680 --> 00:31:10,600
+لهذا المرض ولأنه في الولايات المتحدة الأمريكية
+
+338
+00:31:10,600 --> 00:31:18,760
+فيروس نقص المناعة HIV بدأ اكتشافه في المسلين جنسيا
+
+339
+00:31:18,760 --> 00:31:24,240
+ال homosexuals في مجتمعة المسلين جنسيا سواء اللي
+
+340
+00:31:24,240 --> 00:31:32,110
+بيمارسوا اللواق أو الصحاق في سنة 1988حقيقة انتهينا
+
+341
+00:31:32,110 --> 00:31:36,810
+من بكاليوز في سنة 1980 ماكناش سامعين في هذا
+
+342
+00:31:36,810 --> 00:31:41,370
+الفيروس او هذا المرض بعد ما جينا بسنوات قالوا انه
+
+343
+00:31:41,370 --> 00:31:47,570
+ايجي مرض جنسي اسمه aids وهذا قتل وبدأ يقتل وانتشر
+
+344
+00:31:47,570 --> 00:31:52,740
+من قردة وكلام زي هذاكيف كانت بينتشر بظنوا ان هما
+
+345
+00:31:52,740 --> 00:31:58,800
+في بلد انتروفينس drug users الناس اللي بيعملوا نقل
+
+346
+00:31:58,800 --> 00:32:03,760
+دم من مريض الى سليم او الناس اللي بيحقنوا حالهم
+
+347
+00:32:03,760 --> 00:32:07,980
+بالمخدرات
+
+348
+00:32:07,980 --> 00:32:12,990
+عن طريق الحقنفي مخدرات اتناطة عن طريق الفقهن يعني
+
+349
+00:32:12,990 --> 00:32:18,590
+بيكونوا المدمنين في حلقة وبيقوم واحد بيصير يعني
+
+350
+00:32:18,590 --> 00:32:25,270
+بسرنجةيعني بيعطي كل واحد منهم مثلا واحد يعني صانتي
+
+351
+00:32:25,270 --> 00:32:29,710
+واحد صانتي واحد صانتي فيعني بنفس السن ونفس الإبرة
+
+352
+00:32:29,710 --> 00:32:34,750
+فإذا كان في واحد منهم مصاب يعني بال AIDS ودخلوا في
+
+353
+00:32:34,750 --> 00:32:39,010
+ال vein بتاعه ل vein واحد تاني ممكن انه مصابوا
+
+354
+00:32:39,010 --> 00:32:46,390
+كلهم بعده بال فيروس بقول هو مش بس في ال
+
+355
+00:32:46,390 --> 00:32:52,260
+heterosexualsبل في الـ Homosexual يعني أي ممارسة
+
+356
+00:32:52,260 --> 00:33:00,260
+جنسية في طرفها واحد مريض بالفيروس بنقله للي اللي
+
+357
+00:33:00,260 --> 00:33:05,780
+هو الآخر بنقله للآخر سواء ذكر مع أنثى أو أنثى مع
+
+358
+00:33:05,780 --> 00:33:11,240
+أنثى أو ذكر مع ذكر كله بنقل هذا الفيروس الخبيث
+
+359
+00:33:11,240 --> 00:33:16,440
+ويعني كان كتير منتشر في أفريقيا وفي الدول الفقيرة
+
+360
+00:33:18,180 --> 00:33:24,600
+طيب الآن ايش ال presentation بتاعه ايش هي الأعراض
+
+361
+00:33:24,600 --> 00:33:31,240
+والعلامات بيقول هذا الفيروس يصيب كل أعضاء الجسم
+
+362
+00:33:31,240 --> 00:33:38,260
+every organ and system can be involved كل وصاب اما
+
+363
+00:33:38,260 --> 00:33:43,980
+مباشرة او غير مباشرة مباشرة بفعل الفيروس اللي دخل
+
+364
+00:33:43,980 --> 00:33:49,490
+في الدم ولف في الدم على كل الأعضاء خربهاأو
+
+365
+00:33:49,490 --> 00:33:55,110
+المخلوقات
+
+366
+00:33:55,110 --> 00:34:01,610
+الانتهازية او الكائنات الانتهازية اللى موجودة في
+
+367
+00:34:01,610 --> 00:34:05,250
+جسمنا و
+
+368
+00:34:05,250 --> 00:34:10,960
+الحمد لله لإنهم ممنوعين ان يمارسوا دورهمالمرضى
+
+369
+00:34:10,960 --> 00:34:20,300
+فلما الفيروس يدخل ويحطم ال T lymphocyte بتاعتنا هم
+
+370
+00:34:20,300 --> 00:34:24,880
+بتقووا وبيدرجوا فيش مناقة تصيروا أقوى منها
+
+371
+00:34:27,960 --> 00:34:33,080
+وبيفتكوا في الجسم يبقى التدمير لل organs بتاعت
+
+372
+00:34:33,080 --> 00:34:37,100
+الجسم اما بصير مباشرة عن طريق الفيروس او بطريق غير
+
+373
+00:34:37,100 --> 00:34:41,860
+مباشر انه اضعف ال T-cell خلايا منعية الانفوسايتز T
+
+374
+00:34:41,860 --> 00:34:46,380
+وبالتالي فتح المجال ال opportunistic infection
+
+375
+00:34:46,380 --> 00:34:56,250
+بقول هذه الانفوسايتز لما تنهزم هذه الانفوسايتزتفتح
+
+376
+00:34:56,250 --> 00:35:05,590
+لكل جهاز المناعي ولمفاوي يتورن مثل hyperplasia
+
+377
+00:35:05,590 --> 00:35:12,910
+ولمفاوى الديبليشن كل جهاز المناعة يصبح ضعيف ويصبح
+
+378
+00:35:12,910 --> 00:35:19,070
+هناك نوع من التضخم سنتحدث الأول عن ال systemic
+
+379
+00:35:19,070 --> 00:35:25,390
+manifestations ثم ننزل إلى الالشيء اللي هو ال
+
+380
+00:35:25,390 --> 00:35:30,930
+systemic manifestations يعني ال symptoms و ال
+
+381
+00:35:30,930 --> 00:35:34,770
+signs ال general ال systemic يعني ال general كل
+
+382
+00:35:34,770 --> 00:35:40,170
+جسم cardiac disease في القلب بصيبه myocarditis
+
+383
+00:35:40,170 --> 00:35:44,450
+التهاب عضلة القلب العضلة اللي بتضخ الدم
+
+384
+00:35:44,450 --> 00:35:52,730
+pericarditis التهاب اللي هو الغشاء التاموراللي هو
+
+385
+00:35:52,730 --> 00:35:57,910
+حول القلب pericardium اسمه pericardium كلمة itis
+
+386
+00:35:57,910 --> 00:36:02,590
+يعني اتهاب يبقى التامور صابوا اتهاب endocarditis
+
+387
+00:36:02,590 --> 00:36:07,050
+جطانة القلب الداخلية اللي هو الشغاف endocarditis
+
+388
+00:36:07,050 --> 00:36:10,310
+برضه بتنصاب يعني القلب كله بنصاب من العضلة و
+
+389
+00:36:10,310 --> 00:36:14,450
+الغشاء الخارجي و الغشاء الداخلي طيب ال killer
+
+390
+00:36:14,450 --> 00:36:15,650
+renal disease
+
+391
+00:36:20,130 --> 00:36:24,470
+اللي هو الفيروسي وهذا مزمن يعني يؤدي إلى فشل كلا
+
+392
+00:36:24,470 --> 00:36:27,870
+فيما بعد الجهاز العصبي المركزي central nervous
+
+393
+00:36:27,870 --> 00:36:35,810
+system بصيبه vascular myopathy myopathy
+
+394
+00:36:35,810 --> 00:36:41,170
+يعني التهاب الجهاز العصبي بسبب اللي هو الفيروس
+
+395
+00:36:41,170 --> 00:36:47,470
+vaccular vaccular myopathy هي نوع من الإذابة ونوع
+
+396
+00:36:47,470 --> 00:36:52,290
+من فقد الخلاياالعصبية طيب نجا العين هو ان هذا
+
+397
+00:36:52,290 --> 00:36:57,430
+بيهمنا العين ايه الفيروس عمل في العين اخطر حاجة ان
+
+398
+00:36:57,430 --> 00:37:05,830
+يكون ال ocular opportunistic infection اشتغلت
+
+399
+00:37:05,830 --> 00:37:11,030
+فالocular opportunisticالو انتياجية في العين زى
+
+400
+00:37:11,030 --> 00:37:14,150
+ايش فيروسات فيروسات منها سايكو ميجالوكو فيروس
+
+401
+00:37:14,150 --> 00:37:18,150
+اخدناها هيربس سيمبكس فيروس هيربس دوستر فيروس وهاي
+
+402
+00:37:18,150 --> 00:37:23,250
+نور فانجاي فالان احنا فينا فانجاي ساكتة لما ضاعت
+
+403
+00:37:23,250 --> 00:37:29,110
+الجسم زى ال candy de albicans اه الفتة الأبيض زى
+
+404
+00:37:29,110 --> 00:37:36,330
+كريبتو كوكس نيورو فورمانزوزي نيوموسيستس كارمياي
+
+405
+00:37:36,330 --> 00:37:42,590
+هالي يعني كلها اللي هو فطريات متعايشة الآن و بيصير
+
+406
+00:37:42,590 --> 00:37:47,710
+opportunistic مع مرضى الاست توكسو بلازمه و اخدناها
+
+407
+00:37:47,710 --> 00:37:53,750
+احنا هالي توكسو بلازمه اخدناها هاي الآن ظهرت في
+
+408
+00:37:53,750 --> 00:37:58,660
+العين وعملت احتلال في الشبكيةبكتيريا الانفكشنز
+
+409
+00:37:58,660 --> 00:38:03,360
+كثير في انواع بكتيريا مش هنقول بس تريفوناما مايكو
+
+410
+00:38:03,360 --> 00:38:08,160
+بكتيريام وماتو بكتيريام تريفوكلوزي وعديد من ال
+
+411
+00:38:08,160 --> 00:38:14,500
+بكتيريا البكتيريا العفوية اللى بتكون فى العين ممكن
+
+412
+00:38:14,500 --> 00:38:20,820
+انه حتى تيجي تكون اندوجنس يعني من داخل الجسم وتلف
+
+413
+00:38:20,820 --> 00:38:24,300
+في دم وتجي على عينه تعمل اندوفعميتس او تعمل
+
+414
+00:38:24,300 --> 00:38:28,530
+كرافيتسهذه مجموعة من ال reportionistic infections
+
+415
+00:38:28,530 --> 00:38:35,750
+ايش بتعمل في العالم؟ بيقوللي انه ال اهم اشي قدرته
+
+416
+00:38:35,750 --> 00:38:41,390
+بحث اعتلال الشبكية الفيروسي بسبب ال aids بفيروس
+
+417
+00:38:41,390 --> 00:38:45,150
+اسمه cytomegalic virus اللي اخدناه قبل هيك الفيروس
+
+418
+00:38:45,150 --> 00:38:50,130
+الكبير megalic الضخم هذا بيعمل في الشبكية حاجتين
+
+419
+00:38:50,130 --> 00:38:58,170
+بيعمل فوق ال ischemiaالكيميا نقص اكسيدين وبالتالي
+
+420
+00:38:58,170 --> 00:39:03,710
+الشبكية بيصير الاكسيدين جليل والنقل العصبي عبر ال
+
+421
+00:39:03,710 --> 00:39:10,410
+روتس والفون و ال retinal cells زي ال bipolar cells
+
+422
+00:39:10,410 --> 00:39:15,510
+و زي الجانجليون cells هتأثر النقل العصبي للصور
+
+423
+00:39:15,510 --> 00:39:22,960
+والسيل الكهربائي هيتأثرو يصير cotton wool spots
+
+424
+00:39:22,960 --> 00:39:28,320
+اللي هو الرشح الأبيض اه بيشوفوه بالأثانسكوب لما
+
+425
+00:39:28,320 --> 00:39:34,200
+نمسك الأثانسكوب بنجي زي الصورة هذه كتير في اللي هو
+
+426
+00:39:34,200 --> 00:39:41,140
+cotton wool spots هذا في أولهاالأخطر من فوق
+
+427
+00:39:41,140 --> 00:39:48,440
+الاسكيميا نقص الدم اللي أثر على اللي هو الوكسيزين
+
+428
+00:39:48,440 --> 00:39:54,780
+للشبكية انه صار internal hemorrhage اللي هو نزيف
+
+429
+00:39:54,780 --> 00:39:59,540
+نزيف عشان فمية من ال patients وهذا بيقدر إلى العمى
+
+430
+00:39:59,540 --> 00:40:05,840
+بيقدر إلى العمى هذه صورة لهذه اللي هو الاسكيميا
+
+431
+00:40:05,840 --> 00:40:10,550
+النقطة البيضة هذهاللي متأثر على النقل العصبي وهنا
+
+432
+00:40:10,550 --> 00:40:15,330
+فيه نزيف وهنا فيه نزيف وهنا فيه نزيف اللي هو
+
+433
+00:40:15,330 --> 00:40:20,610
+retinal haemorrhage اخر slide ما هي البكتيريا
+
+434
+00:40:20,610 --> 00:40:27,530
+اللتي تؤثر على العين في اللي هو ال aids بكتيريا ال
+
+435
+00:40:27,530 --> 00:40:35,790
+infections بقول ان البكتيريا هذه منها triponema
+
+436
+00:40:35,790 --> 00:40:40,290
+pallidumTryponema Pallidum نوع من البكتيريا يعني
+
+437
+00:40:40,290 --> 00:40:43,630
+احنا مش متعلقين ندرس فيه بس نعرف اسمه و
+
+438
+00:40:43,630 --> 00:40:49,970
+Mycobacterium Avium بقتوا Mycobacterium Avium
+
+439
+00:40:49,970 --> 00:40:54,830
+Intracellular يعني داخل الخلية و Mycobacterium
+
+440
+00:40:54,830 --> 00:40:59,410
+Tuberculosis اللي بتعمل السل الرئوي السل الرئوي و
+
+441
+00:40:59,410 --> 00:41:05,070
+هذه سبب وفاة يعني بتعمل عريقتين نظيف شديد و تحطم
+
+442
+00:41:05,070 --> 00:41:09,850
+لحواصلات الهوائيةبجانب العديد من البكتيريا الأخرى
+
+443
+00:41:09,850 --> 00:41:16,610
+التي قد تأتي من الدم عند ضعف المناعة وتؤثر على
+
+444
+00:41:16,610 --> 00:41:21,250
+اللي هو العين تعمل endothalmitis endogenous يعني
+
+445
+00:41:21,250 --> 00:41:22,590
+من داخل الجسم
+
+446
+00:41:28,660 --> 00:41:32,420
+البكتيريا السبروفيتيك ممكن تكون جدا عايشة في
+
+447
+00:41:32,420 --> 00:41:37,340
+القلون عايشة في الجهاز التنفسي بس سبروفيتيك يعني
+
+448
+00:41:37,340 --> 00:41:42,540
+متعايشة و تصير aggressive يعني تصير هجومية وتعمل
+
+449
+00:41:42,540 --> 00:41:46,300
+endophthalmitis وبكتيريا الكيرافيتس انا لعندي اللي
+
+450
+00:41:46,300 --> 00:41:49,840
+هنا يعني بكون انهيت المحاضرة وبانتهاء هذه المحاضرة
+
+451
+00:41:49,840 --> 00:41:54,650
+بكون انهيت هذا المشارط الشيءالجميل من الحياة
+
+452
+00:41:54,650 --> 00:41:57,890
+الدقيقة و أسأل الله عز و جل أن ينفع به و احنا
+
+453
+00:41:57,890 --> 00:42:02,170
+بناتي يعني بعد ظهور الفيروس الجديد اللي هو ال
+
+454
+00:42:02,170 --> 00:42:07,970
+corona حقيقة COVID-19 يعني كتير يعني صار هذا العلم
+
+455
+00:42:07,970 --> 00:42:12,630
+مهم مش احنا بنحس انه دجال علينا و بدنا احنا نرميه
+
+456
+00:42:12,630 --> 00:42:19,250
+بأي طريقة لأ يعني هذا المساق مساق العلماء و
+
+457
+00:42:19,250 --> 00:42:25,900
+المفروض انه احنا نتمفيو مايكرهوش لان للمستقبل و
+
+458
+00:42:25,900 --> 00:42:30,980
+لصحتنا احنا عارفين انه لازم نحافظ عليه و نكون
+
+459
+00:42:30,980 --> 00:42:34,960
+عندنا علوم مبدئية كل عام انتوا بخير و كل فصل
+
+460
+00:42:34,960 --> 00:42:39,360
+وانتوا بخير و ان شاء الله بنجاح تام و بدرجات يعني
+
+461
+00:42:39,360 --> 00:42:42,950
+عاليةو انا متأكد انكم كلكم هتكون ناجحين في كل
+
+462
+00:42:42,950 --> 00:42:48,090
+مسابقات خاصة في هذا المسابق و احنا نسأل الله عز
+
+463
+00:42:48,090 --> 00:42:50,870
+وجل ان انا اتقبل منه و منكم و كل عالم و انتم بخير
+
+464
+00:42:50,870 --> 00:42:52,750
+فالسلام عليكم و رحمة الله
+
diff --git a/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/3uUWjLWHCHQ_postprocess.srt b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/3uUWjLWHCHQ_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..0ab62abdc1167278617bc3d729f564ca4d370c34
--- /dev/null
+++ b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/3uUWjLWHCHQ_postprocess.srt
@@ -0,0 +1,640 @@
+1
+00:00:00,570 --> 00:00:04,410
+أعوذ بالله من الشيطان الرجيم بسم الله الرحمن
+
+2
+00:00:04,410 --> 00:00:10,630
+الرحيم السلام عليكم ورحمة الله وبركاته اودوا اليكم
+
+3
+00:00:10,630 --> 00:00:16,230
+في المحادثة العاشرة في هذا المساءفي موضوع جديد في
+
+4
+00:00:16,230 --> 00:00:25,090
+مساب الأحيان الدقيقة لطلبة العلم او البصريات اليوم
+
+5
+00:00:25,090 --> 00:00:30,330
+هنتناول كيف تقوم البكتيريا بعمل resistance يعني
+
+6
+00:00:30,330 --> 00:00:35,450
+resistance مقاومة لل antimicrobials مضادات
+
+7
+00:00:35,450 --> 00:00:39,600
+البكتيرياكيف يعني هالبكتيريا تستسلم للمضاد الحيوي
+
+8
+00:00:39,600 --> 00:00:46,200
+و لا هي عندها آليات لرفض الاستسلام دعونا نشوف
+
+9
+00:00:46,200 --> 00:00:51,560
+الآلية الأولى drug inactivation انا ايش اقصد
+
+10
+00:00:51,560 --> 00:00:56,420
+inactivation in نفيه و activation تنشيط يعني تثبيت
+
+11
+00:00:56,420 --> 00:01:01,220
+تثبيته او modification او تحويره يعني يبقى يشتغل
+
+12
+00:01:01,220 --> 00:01:06,020
+على البكتيريامثلا انا عندي شئ اسمه penicillin
+
+13
+00:01:06,020 --> 00:01:10,840
+البنسلين معروف بنسلين او المضاد حيوي بيجيب بعض
+
+14
+00:01:10,840 --> 00:01:17,420
+البكتيريا بتفرز انزيم اسمه بنسليناز انزايم من
+
+15
+00:01:17,420 --> 00:01:22,520
+مجموعة ال beta-lactamases انزايم يعني زي اللي هو
+
+16
+00:01:22,520 --> 00:01:27,640
+بنسليناز بتفكك البنسلين و بصير useless يعني غير
+
+17
+00:01:27,640 --> 00:01:33,750
+نافعفي بكتيريا تانية بتضيف أسيتال أو phosphate
+
+18
+00:01:33,750 --> 00:01:37,570
+group للمنضب الحيوي و بصير use this برضه يعني
+
+19
+00:01:37,570 --> 00:01:44,830
+بتدخل فيه هي يعني نوع من المركب الكيميائي اللي
+
+20
+00:01:44,830 --> 00:01:49,010
+يفسده و يخليه يعني غير نافع وهذا برضه تابع
+
+21
+00:01:49,010 --> 00:01:55,440
+للإنزيماتيبقى هذا هيعمل reduction للability بتاع
+
+22
+00:01:55,440 --> 00:01:58,720
+ال antibiotic قدرته to bind to bacteria ribosomes
+
+23
+00:01:58,720 --> 00:02:03,880
+انه يتحد مع ال ribosome ويعمل وقف لل protein
+
+24
+00:02:03,880 --> 00:02:08,360
+synthesis في ال ribosomesيبقى هذا أول شيء
+
+25
+00:02:08,360 --> 00:02:11,760
+البكتيريا بتقاوم المضاد الحيوي انه يتم ال drug
+
+26
+00:02:11,760 --> 00:02:15,800
+inactivation او modification ال activation قولنا
+
+27
+00:02:15,800 --> 00:02:18,680
+inactivation في حالة البنسالين طيب و ال
+
+28
+00:02:18,680 --> 00:02:21,700
+modification في حالة المضاد الحيوي الأخرى اللي
+
+29
+00:02:21,700 --> 00:02:25,880
+بتضيفله مجموعة زي الacetyl or phosphate group يعني
+
+30
+00:02:25,880 --> 00:02:29,380
+بتغير في التركيب الكيميائي للمضاد الحيوي اثنين
+
+31
+00:02:29,380 --> 00:02:36,460
+alteration oftarget site يعني هما بيشبهوا ان
+
+32
+00:02:36,460 --> 00:02:44,780
+المضاد الحيوي زي المفتاح الوثنان والريبوزوم
+
+33
+00:02:44,780 --> 00:02:54,400
+زي الكلون الكلون بتاع الباب إذا المفتاح في الكلون
+
+34
+00:02:54,400 --> 00:02:59,690
+الصحيح بيفتح ان مجهز بيفتحشفي الحالة العادية ان هو
+
+35
+00:02:59,690 --> 00:03:03,250
+المفروض ان يخش ويفتح يعني يقتل اللي هو البكتيريا
+
+36
+00:03:03,250 --> 00:03:08,790
+من عند الريبوزوم لكن تروح البكتيريا ايش تعمل تعرف
+
+37
+00:03:08,790 --> 00:03:15,650
+المضاد الهوي شكله هيك تروح هي تعمله ريبوزوم تغيره
+
+38
+00:03:15,650 --> 00:03:22,050
+هيك يعني بيبطل يلبس فيه وبالتالي بيفترش يستغل عليه
+
+39
+00:03:22,050 --> 00:03:25,510
+هذا alteration يعني تغيير في ال target site في
+
+40
+00:03:25,510 --> 00:03:31,170
+الريبوزومزي مثلا الفنسالين ال target site بتاعه في
+
+41
+00:03:31,170 --> 00:03:35,550
+ال ribosome بتغير وحنشوفه احنا في الشكل هذا كيف
+
+42
+00:03:35,550 --> 00:03:41,170
+يعني هيه كان جاي يعني هاي ال antibiotic لذرك كيف
+
+43
+00:03:41,170 --> 00:03:47,430
+ال target اللحمر اتغير بطل يصير يعني زيه بالظبط لأ
+
+44
+00:03:47,430 --> 00:03:52,200
+صار مثل هيكبدل ما له داخلة يعني المفروض هذا ان
+
+45
+00:03:52,200 --> 00:03:57,740
+يكون ييجي هيك وييجي هيك وييجي هيك وييجي هيك هذا ال
+
+46
+00:03:57,740 --> 00:04:03,920
+ribosome فهو غير حاله صار يعني غير الأسنان فبطل
+
+47
+00:04:03,920 --> 00:04:10,280
+المضاد الحيوي يشتغل الحاجة التالتة ان البكتيريا
+
+48
+00:04:10,280 --> 00:04:15,180
+اتغير في تمثيل الغذائي بتاعها كيف يعني؟ يعني
+
+49
+00:04:15,180 --> 00:04:21,370
+البكتيريابتاخدوا الفوليك أسد مش مباشرة هذا الفوليك
+
+50
+00:04:21,370 --> 00:04:24,290
+أسد بيستخدم في التمثيل الغذائي بتاخده من شيء اسمه
+
+51
+00:04:24,290 --> 00:04:29,850
+بابا البابا بارا عمينو بنزيوك أسد وبعدين لما تاخده
+
+52
+00:04:29,850 --> 00:04:34,930
+بتطلع منه الفوليك أسد طيب الآن الإنسان اكتشف
+
+53
+00:04:34,930 --> 00:04:41,930
+الصلفة sulfonamide هذه مضاد بكتيريالمضاد البكتيريا
+
+54
+00:04:41,930 --> 00:04:45,750
+هذا في شكله بالظبط زي البابا يعني شكله الكيميائي
+
+55
+00:04:45,750 --> 00:04:50,630
+تركيبه زي البابا صار انه لما يروح البكتيريا تحسبه
+
+56
+00:04:50,630 --> 00:04:53,870
+بابا تاخده تموت فالبكتيريا اكتشفت اللعبة هذه
+
+57
+00:04:53,870 --> 00:04:58,850
+استغنت عن الباباغيرت اللي هو في ال metabolic
+
+58
+00:04:58,850 --> 00:05:02,790
+pathway بتاعها وصارت تاخد ال folic acid directly
+
+59
+00:05:02,790 --> 00:05:08,290
+وهذا ارتقاء لما صارت انه اتاخد ال folic acid صارت
+
+60
+00:05:08,290 --> 00:05:11,910
+كأنها زي الإنسان يعني استغنط عن الواسطة بتاعة
+
+61
+00:05:11,910 --> 00:05:18,230
+البابا اللي بيجيبلها اللي هو اللي اللي هو شبه بال
+
+62
+00:05:18,230 --> 00:05:23,690
+salfonamide وبقتلهاالطريقة الرابعة اللى البكتيريا
+
+63
+00:05:23,690 --> 00:05:32,770
+بتعمل فيها مناقة اللى هو resistance او مقاومة اللى
+
+64
+00:05:32,770 --> 00:05:36,790
+بتعمل efflux او pumping out ايش pumping out يعني
+
+65
+00:05:36,790 --> 00:05:44,530
+يعني احنا بنشبه هذا لو واحد بيته أسفل شارع منخفض
+
+66
+00:05:44,530 --> 00:05:50,140
+يعني هذا الشارع هيك وهذا البيت كان زي هيكوصار مطر
+
+67
+00:05:50,140 --> 00:05:55,660
+هنا اش بصير ان الميه بتاعده على الدار لما بتاعده
+
+68
+00:05:55,660 --> 00:05:58,440
+على الدار اهل الدار بيصحوا بيلاقوا ان في ميه في
+
+69
+00:05:58,440 --> 00:06:02,980
+دارهم بيصيروا بيعملوا pumping out بالجفشطات
+
+70
+00:06:02,980 --> 00:06:09,490
+بالمكانس بأي حاجة صحون يطبقوا الميه برافالبكتيريا
+
+71
+00:06:09,490 --> 00:06:14,510
+لما خشها المضاد الحيوي بتحس بالخطر بتعمله قدر إلى
+
+72
+00:06:14,510 --> 00:06:19,110
+الخارج زي الصورة هذه شايف هي efflux او pumping out
+
+73
+00:06:19,110 --> 00:06:24,190
+خش من هنا وطلع من هنا هذا pumping out فهذه احدى
+
+74
+00:06:24,190 --> 00:06:31,290
+الطرق اللي البكتيرياتتخلص فيه من مفعول اللي هو
+
+75
+00:06:31,290 --> 00:06:34,630
+المضاد الحيوي قبل ما يعمل any damage يعني قبل ما
+
+76
+00:06:34,630 --> 00:06:41,430
+يعمل اي اثر تخريبي او اللي هو قتل البكتيريا الشئ
+
+77
+00:06:41,430 --> 00:06:45,470
+الخامس resistance through undergoing bacterial
+
+78
+00:06:45,470 --> 00:06:51,230
+mutation bacterial mutation يعني طفرة بكتيرية
+
+79
+00:06:51,230 --> 00:06:56,760
+البكتيريا وأكتر منها جيروسات في طفرات مستمرةوهذه
+
+80
+00:06:56,760 --> 00:07:01,440
+الطفرات هي تجيير في تركيب الأحماض النووية في النوع
+
+81
+00:07:01,440 --> 00:07:06,900
+اللي هو ال DNA و ال RNA ال DNA و ال RNA فالبكتيريا
+
+82
+00:07:06,900 --> 00:07:13,780
+لما يكون المضاد الحيوي جاي على تركيب نووي معين
+
+83
+00:07:13,780 --> 00:07:20,170
+يقتله أو يغير فيهو يتغير المضادات الحيوية يعدز و
+
+84
+00:07:20,170 --> 00:07:25,270
+بيضلل يعني بيعملوا تضليل و بيقدرش يصلوا كما يجب
+
+85
+00:07:25,270 --> 00:07:33,690
+فهذه يعني من واحد اثنين ثلاثة اربع و هذا الخامسة
+
+86
+00:07:33,690 --> 00:07:38,990
+limitations هذا موضوع مهم موضوع كيف تصنع ال micro
+
+87
+00:07:38,990 --> 00:07:43,550
+organisms خاصة البكتيريا المقاومة للمضادات الحيوية
+
+88
+00:07:43,550 --> 00:07:49,460
+خمس طرقطيب ببنا نلخص موضوع synergism و antagonism
+
+89
+00:07:49,460 --> 00:07:53,120
+between antimicrobials يعني خاصة المضادات الحيوية
+
+90
+00:07:53,120 --> 00:07:57,940
+لو احتاج المريض اكتر مضاد حيوي فانه في الحالة هذه
+
+91
+00:07:57,940 --> 00:08:02,020
+ممكن المضادات الحيوية يصيلها reaction reaction
+
+92
+00:08:02,020 --> 00:08:07,160
+يعني تتفاعل مع بعضها التفاعل هذا فيه اكتر منه فيه
+
+93
+00:08:07,160 --> 00:08:12,220
+independent reactionفي additive reaction وفي
+
+94
+00:08:12,220 --> 00:08:16,300
+synergistic reaction وفي antagonistic reaction ايش
+
+95
+00:08:16,300 --> 00:08:21,920
+يعني؟ يعني لو أعطينا مضاد حيوي A ومضاد حيوي B بيه
+
+96
+00:08:21,920 --> 00:08:26,120
+للإنسان لأن حالته بتستدعي انه ياخد أكتر مضاد حيوي
+
+97
+00:08:26,120 --> 00:08:30,500
+يقولك كل واحد يعمل لوحده ولا يؤثر على التاني هذا
+
+98
+00:08:30,500 --> 00:08:40,090
+independent يعني مستقل additive لأ يعني واحدزي A
+
+99
+00:08:40,090 --> 00:08:49,110
+زي B يساوي AB يعني انه قو بعضهم شويه طيب
+
+100
+00:08:49,110 --> 00:08:55,850
+synergistic ضعفه يعني زي A زي B يساوي 2A
+
+101
+00:08:58,630 --> 00:09:06,490
+زائد اتنين P هذا synergistic تقوية تقوية وتعاضم
+
+102
+00:09:06,490 --> 00:09:11,810
+بينما ال antagonistic او antagonize لأ قضاء يعني
+
+103
+00:09:11,810 --> 00:09:18,850
+زي ما اقول A زائد P يساوي
+
+104
+00:09:18,850 --> 00:09:21,110
+A
+
+105
+00:09:21,870 --> 00:09:28,970
+زائد ب نقصين اتنين نص يعني نص المفهول لانه صار
+
+106
+00:09:28,970 --> 00:09:33,950
+Antagonism المثال للسينيرجيزم التترا سايكلين و
+
+107
+00:09:33,950 --> 00:09:37,370
+كليرم فانيكول لو حاطناهم بيجوا بعض بينما
+
+108
+00:09:37,370 --> 00:09:41,620
+الانتاجونيزم البنسالين و الكليرم فانيكولبيضاضوا
+
+109
+00:09:41,620 --> 00:09:45,840
+بعض وعشان هيك لا الطبيب اللي مايكتبش منسلين و كلهم
+
+110
+00:09:45,840 --> 00:09:50,640
+في نكول وفيه قوائم بين المضادات الحيوية وين يعني
+
+111
+00:09:50,640 --> 00:09:56,300
+بيعضلوا بعض وين بيضاضوا بعض طيب اخر شيء
+
+112
+00:09:56,300 --> 00:09:59,900
+Antibiotics and Stiffness Test لان لو اي جوان
+
+113
+00:09:59,900 --> 00:10:05,260
+المريض وضعه صعب مع نيومونيا نيومونيا يعني زي اللي
+
+114
+00:10:05,260 --> 00:10:08,880
+هو التهاب رئوي او من انذارات التهاب صحائي اغشة
+
+115
+00:10:08,880 --> 00:10:11,780
+المخ من التهابةاحنا مقدرش هذا العيال لما دخلنا
+
+116
+00:10:11,780 --> 00:10:16,720
+المستشفى انه نحطه لما نعمله مزرعات بكتيريا تلت
+
+117
+00:10:16,720 --> 00:10:22,950
+ايام واشي لأ احنا الأفضل انه نعطيه مضاد حيويحسب
+
+118
+00:10:22,950 --> 00:10:28,130
+التجربة والخبرة حسب اللواء المعدة نعطيه مضاد حيوي
+
+119
+00:10:28,130 --> 00:10:32,610
+مثلا لـ pneumonia أو لـ meningitis أو حتى لـ
+
+120
+00:10:32,610 --> 00:10:37,050
+gastroenteritis نعطيه مضاد حيوي و بعد هيك احنا قبل
+
+121
+00:10:37,050 --> 00:10:40,490
+ما نعطيه مضاد حيوي بنكون سحبنا عينة من البول او
+
+122
+00:10:40,490 --> 00:10:45,930
+البراز او الدم او السائر الشوكي او الغلغم حسب اللي
+
+123
+00:10:45,930 --> 00:10:49,510
+هو مكان الإصابة قبل ما نعطيه مضاد حيوي بناخد منه
+
+124
+00:10:49,510 --> 00:10:56,040
+عينةوبعدين بنعمل مزرعة بكتيريا المزرعة البكتيرية
+
+125
+00:10:56,040 --> 00:11:00,860
+هذه بنجيب وسط ملائم زي مثلا اجار او blood agar
+
+126
+00:11:00,860 --> 00:11:05,720
+يعني وسط فيه طعام معين وفي وسط اكسيجين معين يعني
+
+127
+00:11:05,720 --> 00:11:11,160
+لازم حرارة مناسبة وناخد العينة وناخد نكب في
+
+128
+00:11:11,160 --> 00:11:16,930
+المزرعة البكتيرية هذه اه في جو مناسب تلات أياموبعد
+
+129
+00:11:16,930 --> 00:11:21,470
+تلت أيام بناخد البكتيريا نعمل isolation ناخد تحت
+
+130
+00:11:21,470 --> 00:11:25,210
+الميكروسكوب نشقص إيش هي البكتيريا هل هي step
+
+131
+00:11:25,210 --> 00:11:30,010
+الكوكاية step الكوكاية guano كوكاية إيش راشية أه
+
+132
+00:11:30,010 --> 00:11:35,490
+يعني واحدة منهم بنقول إن المسبب هذا هو البكتيريا
+
+133
+00:11:35,490 --> 00:11:40,840
+الفلانيةطيب الآن هذه البكتيريا بنبدأ احنا لما نمت
+
+134
+00:11:40,840 --> 00:11:44,380
+فيها في المزارع البكتيرية كويس كويس بنبدأ انجزها
+
+135
+00:11:44,380 --> 00:11:48,920
+المزارع البكتيرية الى دوائر دائرة اونى دائرة تانية
+
+136
+00:11:48,920 --> 00:11:54,140
+دائرة رابعة تالتة رابعة خمسة ايش الدوائر اللي نمت
+
+137
+00:11:54,140 --> 00:11:58,000
+فيها في كل دائرة بنحط مضاد حيوي ABCD مختلف عن
+
+138
+00:11:58,000 --> 00:12:03,510
+التاني زي هيك يعني حط مضاد حيوي مختلفبيفضل هذا
+
+139
+00:12:03,510 --> 00:12:07,470
+ثلاث أيام بعد ثلاث أيام نيلي احنا نكشف وين
+
+140
+00:12:07,470 --> 00:12:14,670
+البكتيريا ماتت هانا اكتر هانا لم تموت اللي بتموت
+
+141
+00:12:14,670 --> 00:12:20,030
+اكتر زي هانا مثلا بيقول هذه ايش اكتر اشي مضاد حيوي
+
+142
+00:12:20,030 --> 00:12:24,010
+يقتل البكتيريا هذه اكتر شيء لما تكون مثلا هانا مش
+
+143
+00:12:24,010 --> 00:12:28,270
+ميتة بيقول لأ هذا resistant يعني بتقاوم البكتيريا
+
+144
+00:12:28,690 --> 00:12:33,570
+وبالتالي احنا بصير ان يعني معلومات عن اللي هو
+
+145
+00:12:33,570 --> 00:12:37,490
+المضادات الحيوية A وB وC وD وE في ناس بيعملوا
+
+146
+00:12:37,490 --> 00:12:42,070
+عشرين مضاد حيوي وفي الآخر بيعملوا جدول الجدول هنا
+
+147
+00:12:42,070 --> 00:12:47,450
+في المضاد الحيوي هو كم نسبة قتل البكتيريا خمس
+
+148
+00:12:47,450 --> 00:12:52,570
+درجات اربع درجات تلت درجات درجتين درجة او لا يقتل
+
+149
+00:12:52,570 --> 00:12:57,760
+الآن بقى تلت أيام رجعنا للعيان المسكيناذ كان احنا
+
+150
+00:12:57,760 --> 00:13:00,420
+لجينا حالته اتحسنت من المضادة الحقيقية والافتراضي
+
+151
+00:13:00,420 --> 00:13:03,960
+اللي اعطيناه في الاول بتخليه يكمل بقى جل سبوع مثلا
+
+152
+00:13:03,960 --> 00:13:09,240
+عالية او اكتر لكن لجينا حالته صعبة او مااتحسنش
+
+153
+00:13:09,240 --> 00:13:12,680
+بنعمل شي اسمه re-adjustment
+
+154
+00:13:16,130 --> 00:13:20,270
+حتى نغيّر المضاد الحيوي الأولاني بالمضاد الحيوي
+
+155
+00:13:20,270 --> 00:13:24,510
+اللي حسب المزرعة اللي طلع قوي كتير في هذه المزرعة
+
+156
+00:13:24,510 --> 00:13:28,830
+البكتيرية وهيك احنا ممكن خدمنا العيان اول اشي
+
+157
+00:13:28,830 --> 00:13:32,970
+اعطينا من اولها مضاد حيوي بعدين حاجة تانية انه
+
+158
+00:13:32,970 --> 00:13:39,900
+احنا ماتولناش عليهبتلت أيام وبعدين ممكن انه يعملوا
+
+159
+00:13:39,900 --> 00:13:43,440
+readjustment في حالة انه ما استفاد من المضاد
+
+160
+00:13:43,440 --> 00:13:44,800
+الحيوي الأول
+
diff --git a/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/4g57gfQyHEY_raw.srt b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/4g57gfQyHEY_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f7858d5105d61f99b58f229bef6749e44c8868a1
--- /dev/null
+++ b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/4g57gfQyHEY_raw.srt
@@ -0,0 +1,892 @@
+1
+00:00:01,740 --> 00:00:06,580
+أعوذ بالله من الشيطان الرجيم بسم الله الرحمن
+
+2
+00:00:06,580 --> 00:00:11,980
+الرحيم الحمد لله و أكفه و أصلي و أسلم على النبي
+
+3
+00:00:11,980 --> 00:00:18,840
+مصطفى بناتي طالبات طلب الصلاة الطبية المستوى
+
+4
+00:00:18,840 --> 00:00:23,680
+الثالث السلام عليكم و رحمه الله وبركاته أعوذ ولكم
+
+5
+00:00:25,130 --> 00:00:31,610
+في هذه المحاضرة السادسة عشرة آمن بالله عز وجل أن
+
+6
+00:00:31,610 --> 00:00:37,150
+تكونوا في أحسن حال وقد يعني عجبتني درجاتكم الحقيقة
+
+7
+00:00:37,150 --> 00:00:46,230
+في ال ال quiz اللي يعني أخدتهم معي وانا الحقيقة
+
+8
+00:00:46,230 --> 00:00:52,330
+اني يعني أشد على أيديكم انه في زحمة محاضراتلكن
+
+9
+00:00:52,330 --> 00:00:57,530
+ترتيب الوقت حقيقة والإسلام علمنا كيف انه احنا نرتب
+
+10
+00:00:57,530 --> 00:01:00,710
+الوقت ارجو ان تكونوا واصلاتكم من محاضرة الخامسة
+
+11
+00:01:00,710 --> 00:01:05,790
+عشرة حول ال COVID-19 هذه محاضرة مهمة حقيقة لان هي
+
+12
+00:01:05,790 --> 00:01:09,470
+موضوع الساعة والان في هذه المحاضرة السادسة عشرة
+
+13
+00:01:09,470 --> 00:01:15,910
+هنبدأ نكمل الفيروسات في شيء اسمه viruses and
+
+14
+00:01:15,910 --> 00:01:23,440
+disease process يعني ما هي اثراللي هو الويروسات في
+
+15
+00:01:23,440 --> 00:01:29,100
+إحداث المرض عندما تدخل ويروسات الجسم يعني العملية
+
+16
+00:01:29,100 --> 00:01:34,280
+المرضية التي تسببها الويروسات في الجسم بيقول إنه
+
+17
+00:01:34,280 --> 00:01:39,560
+العملية هذه اسمها cytopathic effect cytopathic
+
+18
+00:01:39,560 --> 00:01:45,640
+effect cytopathic يعني هذه كلمتين مع بعض cyt خلية
+
+19
+00:01:45,640 --> 00:01:51,670
+من ال cell يعنيو pathic اللي هو disease pathology
+
+20
+00:01:51,670 --> 00:01:57,330
+يعني فبقول يعني مرض الخلية pathic effect اللي هو
+
+21
+00:01:57,330 --> 00:02:03,270
+الأثر المرضي على الخليةعندما تدخل الفيروسات إلى
+
+22
+00:02:03,270 --> 00:02:11,790
+الخلية الحية مثلا في الإنسان بتبدأ life cycle اللي
+
+23
+00:02:11,790 --> 00:02:16,550
+هو يعني دورة حياة ليتك، ليتك يعني إذابة إذابة
+
+24
+00:02:16,550 --> 00:02:23,400
+إتقالاف الخلية الحية بالفيروس عن طريق الإنزيماتطيب
+
+25
+00:02:23,400 --> 00:02:29,440
+هنا ال cytopathic effect هذا فيه له خمس خمس مراحل
+
+26
+00:02:29,440 --> 00:02:33,680
+المرحلة الأولى اسمها changes in cell membrane
+
+27
+00:02:33,680 --> 00:02:38,460
+permeability of host cell يعني هاي اللي هو الخلية
+
+28
+00:02:38,460 --> 00:02:44,100
+الحية وهي ال virus اللي ده هنا وجفلما واجه هنا بدأ
+
+29
+00:02:44,100 --> 00:02:49,740
+يفلس انزيمات حوالين هذه الحالية انزيمات هذه ايش
+
+30
+00:02:49,740 --> 00:02:56,100
+بتسوي بتغير نفاذية اللى هو الغلاف بتاع الحالية
+
+31
+00:02:56,100 --> 00:03:05,000
+الحية بتاع الإسان يعني بصير اللى الغلافيدخل المواد
+
+32
+00:03:05,000 --> 00:03:11,080
+ويطلعها بدون حساب دقيق لمكان هو في الصحة فبصير
+
+33
+00:03:11,080 --> 00:03:15,320
+changes يعني تغيرات في ال membrane permeability ال
+
+34
+00:03:15,320 --> 00:03:18,140
+membrane بتاع ال cell membrane بتاع الخلية بتاعة
+
+35
+00:03:18,140 --> 00:03:22,460
+الإنسان تبدأ ال permeability النفاذية بتاعته أنها
+
+36
+00:03:22,460 --> 00:03:28,180
+تتغيرالخطوة التانية loss of essential metabolic
+
+37
+00:03:28,180 --> 00:03:35,020
+products of host cells تبدأ السل هذه الخلية لمرضى
+
+38
+00:03:35,020 --> 00:03:41,040
+تطلع مواد غلائية أو نواتج التمثيل الغلائي إلى
+
+39
+00:03:41,040 --> 00:03:45,780
+الخارج هذا الفيروس طبعا هيتغذى عليها هي خطافة
+
+40
+00:03:45,780 --> 00:03:50,880
+اختراقياخد طريقة اختراق من المواد اللى طلعت فيها
+
+41
+00:03:50,880 --> 00:03:56,060
+في الانزيمات الفيروسية اللى افرزها الانزيم من خارج
+
+42
+00:03:56,060 --> 00:04:02,000
+يبقى لما طلعت ال product الان من ضمن الأشياء اللى
+
+43
+00:04:02,000 --> 00:04:05,780
+طلعت اللى هو essential enzymes اللى طلعت برا
+
+44
+00:04:05,780 --> 00:04:11,550
+essential enzymes من الخلية الحيةو هذا بيعمل عملي
+
+45
+00:04:11,550 --> 00:04:17,710
+destruction يعني تدمير of host genes تدمير لاللي
+
+46
+00:04:17,710 --> 00:04:22,190
+هو الجينات الإنسانية أو في الخلية المصابة يعني
+
+47
+00:04:22,190 --> 00:04:26,550
+الجينات اللي هي بتكون في النواة هنا هيبقى اسلها
+
+48
+00:04:26,550 --> 00:04:35,050
+عملية تلف لأنه يعني صار خروج لمواد أساسية خارج
+
+49
+00:04:35,050 --> 00:04:41,860
+الخليةالشيء الرابع في الاصيتواباتك effect انه ال
+
+50
+00:04:41,860 --> 00:04:46,840
+infected cells يعني الخلايا المصابة في المنطقة
+
+51
+00:04:46,840 --> 00:04:54,100
+المعينة اللي أصيبت بتشكل giant multi nuclear cell
+
+52
+00:04:54,100 --> 00:05:01,620
+يعني مثلا أنا عند أشخاص خلية أصيبت بالويروسات مثلا
+
+53
+00:05:01,620 --> 00:05:08,240
+في الكبد أو أصيبت في الرئةأو أصيبت في البنكريات او
+
+54
+00:05:08,240 --> 00:05:16,460
+في المعدة هذه الخلايا تتكون لها شيء كبير اسمه
+
+55
+00:05:16,460 --> 00:05:21,280
+syncytium شيء كبير اسمه syncytium وهذه الخلايا
+
+56
+00:05:21,280 --> 00:05:25,900
+التالفة اللى فيها الفيروسات هنا الصورة بتبين ال
+
+57
+00:05:25,900 --> 00:05:33,230
+syncytium هاي الفيروس اول اشي هذا الفيروسال V
+
+58
+00:05:33,230 --> 00:05:40,910
+فيروس خش في ال cell بتاعة ال host host H الآن
+
+59
+00:05:40,910 --> 00:05:47,490
+الاتحاد الأولاني اسمه cincherion cincherion أول
+
+60
+00:05:47,490 --> 00:05:54,470
+درجة من غزوه اللي هو الفيروس الآن بتوسع الأمر بزيد
+
+61
+00:05:54,470 --> 00:06:00,440
+الفيروسات فبصير heterocherion heterocherionلما
+
+62
+00:06:00,440 --> 00:06:04,700
+يتوسع الغضب اكتر وتتكاثر الفيروسات اسمه syncytium
+
+63
+00:06:04,700 --> 00:06:10,040
+اي مجموعة الخلايا شوف كده خلية واحدة مصابة صارت
+
+64
+00:06:10,040 --> 00:06:15,780
+مجموعة خلايا مصابة اسمها syncytium هي الخلية
+
+65
+00:06:15,780 --> 00:06:20,180
+الكبرى التي تتجمع فيها الخلايا المصابة زي مثلا هذه
+
+66
+00:06:20,180 --> 00:06:27,530
+شوف هذه كل هيك syncytiumفتموت خلايا مصابة
+
+67
+00:06:27,530 --> 00:06:34,330
+بالفيروسات اسمها syncytium الشيء الأخير تكون أجسام
+
+68
+00:06:34,330 --> 00:06:38,370
+مضادة ال antibodies يعني الجسم لما يدعج أن الفيروس
+
+69
+00:06:38,370 --> 00:06:45,110
+دخل فيه وعمل يعني syncytium و ببدأ أن الخلايا
+
+70
+00:06:45,110 --> 00:06:48,950
+المنعية تكون antibodies ايش antibodies يعني أن
+
+71
+00:06:48,950 --> 00:06:54,190
+أجسام مضادة حتى لو الفيروس دخل الجسم مرة تانية
+
+72
+00:06:54,190 --> 00:07:00,580
+فيما بعد تصدرهمثلا افترضوا ان الفيروس هذا شكله هيك
+
+73
+00:07:00,580 --> 00:07:09,560
+شكله هيك ال antibodies هتتشكل له بحيث انه تكون
+
+74
+00:07:09,560 --> 00:07:16,920
+بالظبط على المجس يبقى هذا الفيروس الفيروس انتي جين
+
+75
+00:07:16,920 --> 00:07:23,640
+انتي جين بتكونله antibodyAntibody فلو الفيروس بعد
+
+76
+00:07:23,640 --> 00:07:27,680
+سنة او سنتين او تلاتة او اربعة بيجي بصير Antigen
+
+77
+00:07:27,680 --> 00:07:31,020
+Antibody reaction و الفيروس مقدرش يختلق و مقدرش
+
+78
+00:07:31,020 --> 00:07:34,840
+يعمل عملية مرضية جديدة كطعيمات اللتي كنا ناخدها
+
+79
+00:07:34,840 --> 00:07:37,160
+وانا عند صغار السن
+
+80
+00:07:39,250 --> 00:07:43,910
+طيب الآن ال بيروس لما دخل وعمل ال cytopathic
+
+81
+00:07:43,910 --> 00:07:49,390
+effect هذا اه ال symptoms بتاعته اما بتكون واضحة
+
+82
+00:07:49,390 --> 00:07:53,860
+او غير واضحة اذا كان واضحة اسمها clinicalأه يبقى
+
+83
+00:07:53,860 --> 00:07:58,860
+هذه هي unique يعني فريدة لكل نوع من الفيروسات
+
+84
+00:07:58,860 --> 00:08:03,400
+الأعراض فريدة لكل نوع من الفيروسات الفلوانزا مثلا
+
+85
+00:08:03,400 --> 00:08:07,540
+فيروس الفلوانزا ماعرف إيش بعمل بعمل رشح بعمل سخونة
+
+86
+00:08:07,540 --> 00:08:14,240
+بعمل كحة بعمل إفرازات في الأنث مثلا فيروس الإسهال
+
+87
+00:08:14,240 --> 00:08:18,640
+بعمل إسهال و بعمل مغص و إشي كده مثلا في فيروس
+
+88
+00:08:18,640 --> 00:08:24,490
+الكبد بعمل تهاب في الكبد و ألم و سفارفهذه unique
+
+89
+00:08:24,490 --> 00:08:31,450
+symptoms يعني فريدة منوحة لكل فيروس وهذه تعكس
+
+90
+00:08:31,450 --> 00:08:37,630
+طبيعةاللي هو ال life cycle بتاعة الفيروس life
+
+91
+00:08:37,630 --> 00:08:43,890
+cycle يعني اللي هو دورة الحياة بتاعة الفيروس قولت
+
+92
+00:08:43,890 --> 00:08:50,190
+انا انه الفيروس اما بيعمل clinical symptoms او sub
+
+93
+00:08:50,190 --> 00:08:54,030
+clinical symptoms clinical symptoms الواضحة يعني
+
+94
+00:08:54,030 --> 00:08:58,370
+واحد مثلا يصير سخن و يصير معاه كحة و يصير معاه
+
+95
+00:08:58,370 --> 00:09:03,090
+يعني دوخة و بده طبيبsub-clinical لأ بيكون ال .. ال
+
+96
+00:09:03,090 --> 00:09:07,110
+.. ال .. اللي هو ال .. ال symptoms أجل يعني ممكن
+
+97
+00:09:07,110 --> 00:09:12,810
+يكون سخونة خفيفة، بيكون سعاد خفيف، ال sub-clinical
+
+98
+00:09:12,810 --> 00:09:15,770
+بوديش على الطبيب، بوديش على المستشفى، لكن ال
+
+99
+00:09:15,770 --> 00:09:20,740
+clinical symptoms بتودي على الطبيبطيب كتير مننا
+
+100
+00:09:20,740 --> 00:09:25,440
+احنا بنصاب .. بنصاب clinical infection يعني بي ..
+
+101
+00:09:25,440 --> 00:09:29,820
+يعني صاب أجل يعني من ال clinical الواضح يعني أجل
+
+102
+00:09:29,820 --> 00:09:35,680
+كتير مننا بنصاب و بيشفى اه و بتكون ال infection
+
+103
+00:09:35,680 --> 00:09:39,140
+inapparent inapparent يعني غير واضحة كتير بياخدش
+
+104
+00:09:39,140 --> 00:09:43,900
+علاج و بطيب الحمد لله في أيام هل ال sub clinical
+
+105
+00:09:43,900 --> 00:09:48,340
+بتعمل مناعة بيقول اهال subclinical و لو انها
+
+106
+00:09:48,340 --> 00:09:53,680
+subclinical stimulate يعني تحفظ جهاز المناعة على
+
+107
+00:09:53,680 --> 00:09:57,380
+انه يعمل lifelong term immunity يعني مناعة طولة
+
+108
+00:09:57,380 --> 00:10:02,960
+الأمد في الجسم ضد الويروسات في المستقبلولو انه
+
+109
+00:10:02,960 --> 00:10:07,280
+subclinical وهذا اللى بيصير انه لما يعطوا التطعيم
+
+110
+00:10:07,280 --> 00:10:12,200
+التطعيم لو فاكرين لما طعم الطفل الصغير بصير سخن
+
+111
+00:10:12,200 --> 00:10:16,640
+شوية و بصير يعني تعبان شوية يوم يومين و بطيب هذه
+
+112
+00:10:16,640 --> 00:10:20,800
+اسمها subclinical هذه ولو انها subclinical التطعيم
+
+113
+00:10:20,800 --> 00:10:26,120
+اللى أخده هتعمله life long term immunity يعني
+
+114
+00:10:26,120 --> 00:10:30,540
+مناعة طويلة الأمد ممكن تكون طول العمر زى مثلا
+
+115
+00:10:30,540 --> 00:10:38,140
+الحصبةفي ولد بيحصم و بيخدها
+
+116
+00:10:38,140 --> 00:10:43,740
+مدد الحياة و في بياخدها vaccine يعني تتعينالشيء
+
+117
+00:10:43,740 --> 00:10:47,720
+التاني بتاع ال subclinical ان ال cytopathic effect
+
+118
+00:10:47,720 --> 00:10:53,080
+بتاع ال subclinical مستمر و قد يعني يحطم في
+
+119
+00:10:53,080 --> 00:10:58,300
+الإنسان يعني أشياء أو أعضاء منه زي مثلا المرأة
+
+120
+00:10:58,300 --> 00:11:04,760
+الحامل عندما تنصاب بيه اللي هو rubella infection
+
+121
+00:11:04,760 --> 00:11:08,920
+rubella infection حصبة الألمانية الحصبة الألمانية
+
+122
+00:11:08,920 --> 00:11:15,190
+إذا أصابت المرأة الحاملفإنها تؤثر فيها خفيفا لكن
+
+123
+00:11:15,190 --> 00:11:21,150
+قد تحطم وتدمر اللي هو الجنين اللي ليه في بطن تلك
+
+124
+00:11:21,150 --> 00:11:25,350
+الأم يعني ال virus بيبلا بتاع الحصب الألماني
+
+125
+00:11:25,350 --> 00:11:29,490
+german measles ممكن ان الcytopathic effect تكون
+
+126
+00:11:29,490 --> 00:11:35,590
+على المرأة خفيف لكن على الجنين يكون صعب الآن هنتخل
+
+127
+00:11:35,590 --> 00:11:39,510
+إلى موضوع اللي هو ال vaccine ال vaccine يعني تطعيم
+
+128
+00:11:39,510 --> 00:11:45,940
+ضد الفيروساتفحقيقة الإنجاز الكبير يعني بدأ يعني في
+
+129
+00:11:45,940 --> 00:11:51,420
+القرن الماضي لما أعلنوا سنة ألف سمية وتسعة وسبعية
+
+130
+00:11:51,420 --> 00:11:57,380
+من القرن الماضي انتهاء اللي هو مرض الجدري smallpox
+
+131
+00:11:57,380 --> 00:12:02,300
+وانا كنت يعني في آخر سنة في كلقة الطب وصار اتفاق
+
+132
+00:12:02,300 --> 00:12:08,270
+عالميانه declared اعلنوا successfully eradication
+
+133
+00:12:08,270 --> 00:12:16,770
+انتهاء من بنجاح من smallpox اللي هو ال WHO منظمة
+
+134
+00:12:16,770 --> 00:12:22,750
+الصحة العالمية هذه يعني اعلنت اكتشاف vaccine ل
+
+135
+00:12:22,750 --> 00:12:30,490
+smallpox وانه اصبح يقولوا ان smallpoxthe point of
+
+136
+00:12:30,490 --> 00:12:37,470
+no return يعني انتهوا
+
+137
+00:12:37,470 --> 00:12:41,750
+منه تماما شوفوا الشكل هذا هذا الطفل المسكين كان
+
+138
+00:12:41,750 --> 00:12:48,560
+معاه جدري شوفوا كل جسمه كيفهذا يعني مشوه هذا ممكن
+
+139
+00:12:48,560 --> 00:12:52,940
+كمان يموت فيعني كانت بتصيب هذه ملايين من الأطفال
+
+140
+00:12:52,940 --> 00:12:58,480
+في العالم و أنا طفل كنت أشوف فعلا أطفال مصابين
+
+141
+00:12:58,480 --> 00:13:02,260
+يعني بهذا الفيروس و بعدين الحمد لله في سنة تسعة و
+
+142
+00:13:02,260 --> 00:13:07,280
+سبعين أعلنوا انتهاء smallpox و قالوا انه مش هيعود
+
+143
+00:13:07,280 --> 00:13:17,340
+ان شاء الله يبقى ال vaccine او التطبيق هذاهم بعطوه
+
+144
+00:13:17,340 --> 00:13:26,150
+للمريض عشان يعني يعمل antibodiesو يكون جاهز لغزو
+
+145
+00:13:26,150 --> 00:13:31,490
+فيروسى اول ما يجى الفيروس بصير انتيجين انتي بودي
+
+146
+00:13:31,490 --> 00:13:38,990
+reaction و الفيروس مقدرش انه يدمر في الجسم شيء هذا
+
+147
+00:13:38,990 --> 00:13:44,410
+الفيروس انتيجين وهذا الانتي بودي اللى هو بتلجأ فلو
+
+148
+00:13:44,410 --> 00:13:47,730
+صار انتيجين انتي بودي reaction الفيروس مكنوش حر
+
+149
+00:13:47,730 --> 00:13:52,650
+بكون ده الحرامى اللى تكتفناه ومقدرش يشرب يعنى
+
+150
+00:13:54,590 --> 00:13:58,730
+الحقيقة الفاكسينات مش مواحدة الفاكسينات أنواع في
+
+151
+00:13:58,730 --> 00:14:04,590
+فاكسين attenuated awakened vaccine يعني هو فيروس
+
+152
+00:14:04,590 --> 00:14:12,230
+حي لكنه ضعيف ضعيف يعني ربما بفعل يعني تعرضوا لأشعة
+
+153
+00:14:12,230 --> 00:14:20,730
+ضعيف بفعل يعني وضعوا في المعمل بكون هو ضعيف بيجهد
+
+154
+00:14:20,730 --> 00:14:28,100
+لحجمه في المريضوبيعمل pathogenesis يعني بيعمل مرض
+
+155
+00:14:28,100 --> 00:14:32,560
+لكن خفيف greater than usual يعني بيستخلوا يوم
+
+156
+00:14:32,560 --> 00:14:36,800
+يومين بيتعابلوا الولد الصغير شوية وهذا يشبه او
+
+157
+00:14:36,800 --> 00:14:43,420
+يحاكي الفيروس الأصلي اللي بيعمل اللي هو immune
+
+158
+00:14:43,420 --> 00:14:47,040
+response او antibodies في الجسم فلو هو عمل
+
+159
+00:14:47,040 --> 00:14:51,750
+antibodiesوأجى الفيروس الأصلي في يوم من الأيام
+
+160
+00:14:51,750 --> 00:14:58,990
+بيكون انه مقدرش يعمل المرض كامل المثال ايه المضروب
+
+161
+00:14:58,990 --> 00:15:03,630
+على هذا اسمه polio vaccine polio يعني شر الأطفال
+
+162
+00:15:04,010 --> 00:15:10,250
+شعر الأطفال اكتشفوا البرت سابين vaccine البرت
+
+163
+00:15:10,250 --> 00:15:14,850
+سابين اكتشف اللي هو ال vaccine بتاع شعر الأطفال
+
+164
+00:15:14,850 --> 00:15:20,850
+سنة قبل 160 من قرن الماضي يعني قبل حوالي ستين سنة
+
+165
+00:15:20,850 --> 00:15:25,470
+قبل حوالي ستين سنة يبقى هذا النوع الأول من ال
+
+166
+00:15:25,470 --> 00:15:30,230
+vaccine أو التقيمات هو ال attenuated يعني فيروس حي
+
+167
+00:15:30,230 --> 00:15:38,030
+live لكنهضعيف دكنه ضعيف بفعل عوامل معينة بحجنه
+
+168
+00:15:38,030 --> 00:15:44,210
+خاصة يعني شال الأطفال فيعني بيعمل مناعة دون أن
+
+169
+00:15:44,210 --> 00:15:47,750
+يعمل مرض كبير البفنوليزيات بتاعته بتكون جليلة
+
+170
+00:15:48,170 --> 00:15:52,510
+منخفضة ال pathogenicity خفيفة وبالتالي الطفل بيحمل
+
+171
+00:15:52,510 --> 00:15:56,270
+antibodies مدى الحياة لو اجى ويروشها الأطفال
+
+172
+00:15:56,270 --> 00:16:03,330
+بتفضلها و بيصير الشداء لأطفال مع هذا الطفل ال
+
+173
+00:16:03,330 --> 00:16:09,400
+vaccine التانيinactivated vaccines inactivated in
+
+174
+00:16:09,400 --> 00:16:15,660
+يعني نفي نفي لل activity للنشاط يعني غير منشطة
+
+175
+00:16:15,660 --> 00:16:22,080
+اللي اللي هو الفيروسات هذه وهذه بيكون فيها الفيروس
+
+176
+00:16:22,080 --> 00:16:27,580
+اتعرض إلى denaturating agent denaturating تغيير
+
+177
+00:16:27,580 --> 00:16:31,810
+الطبيعة بتاعتهزي الفورمالين الفورمالين هيقولنا ان
+
+178
+00:16:31,810 --> 00:16:37,410
+هو مادة يعني مطاهرة من مواد مطاهرة اللى تحفظ
+
+179
+00:16:37,410 --> 00:16:43,430
+البيوتث من التعفن فهذا الفيروس لو مرجوه في
+
+180
+00:16:43,430 --> 00:16:49,410
+الفورمالين هيصير inactivated مامتش بس مافيش فيه
+
+181
+00:16:49,410 --> 00:16:54,480
+نشاطالفيروس بتاع ال influenza هو المثال الحي لهذا
+
+182
+00:16:54,480 --> 00:16:58,540
+يعني بجيبوا الفيروس ال influenza من المريض و بكون
+
+183
+00:16:58,540 --> 00:17:03,620
+جاوي جدا بدخله على ال formalin بصير inactivated
+
+184
+00:17:03,620 --> 00:17:09,500
+inactivated لو أخدنا تطيب influenza على طول هيبدأ
+
+185
+00:17:09,500 --> 00:17:16,890
+يعملي antibodies اه بيعملي antibodiesمع سخونة
+
+186
+00:17:16,890 --> 00:17:22,590
+خفيفة او اشي وهذه الانتيبوديز بتكون جاهزة اه لو
+
+187
+00:17:22,590 --> 00:17:26,110
+اجت من الفرموزة الحقيقية لتصدرها بيعمل انتيجين
+
+188
+00:17:26,110 --> 00:17:30,310
+انتيبودي رياكشن زي اللي احنا ورناكوا يال ان انا
+
+189
+00:17:30,310 --> 00:17:36,830
+اشبك فيه بيخلهوش هو يعمل والان يقال انه هيبدأوا
+
+190
+00:17:36,830 --> 00:17:42,860
+بمناسبة دخول الشتاءإنه يعملوا تطعيم عام للناس ضد
+
+191
+00:17:42,860 --> 00:17:47,260
+اللي هو ال influenza لإنه الوروسات هذه بتنتشر في
+
+192
+00:17:47,260 --> 00:17:52,660
+الشتاء و ال corona موجود الآن فبدهم الشيء اللي هو
+
+193
+00:17:52,660 --> 00:17:56,480
+يهم ال corona و يحمل ال influenza و الله يسهل و
+
+194
+00:17:56,480 --> 00:18:01,430
+نجد كلنا تطعيم لل influenza ان شاء اللهالشيء
+
+195
+00:18:01,430 --> 00:18:05,370
+التالت أو النوع التالت من ال vaccine التطييمات هذه
+
+196
+00:18:05,370 --> 00:18:08,810
+بيقول
+
+197
+00:18:08,810 --> 00:18:16,110
+ان هذا ال virus اه يحتوي على جزء من ال virus يعني
+
+198
+00:18:16,110 --> 00:18:23,150
+مش كل ال virus كامل لأن بطريقة علميةأه بياخدوا
+
+199
+00:18:23,150 --> 00:18:29,950
+تكنولوجيا اسمها ال DNA أه تكنولوجيا أه اللقاح
+
+200
+00:18:29,950 --> 00:18:33,450
+مقتلف يحفظ تكوين الأسنان من المضادة يعني بياخدوا
+
+201
+00:18:33,450 --> 00:18:37,770
+جزء من ال DNA اللي في الخلية و بيحكموه مش كله يعني
+
+202
+00:18:37,770 --> 00:18:45,930
+بيكون sub unit يعني جزء من ال vaccine منه ال DNA
+
+203
+00:18:45,930 --> 00:18:53,110
+اللي يحكموهوبيعمل هذا يعني مناعة ضد الفيروس الشهير
+
+204
+00:18:53,110 --> 00:18:58,990
+Hepatitis B vaccine اللي بنتخل بنقل الدم بنقل الدم
+
+205
+00:18:58,990 --> 00:19:05,450
+بنتخل اللي هو اتهاب الفيروس الوبائي بنتخل اللي هو
+
+206
+00:19:05,450 --> 00:19:13,190
+نقل الدم فهذا برضه يعني بيعطوه للأطباء والممرضين و
+
+207
+00:19:13,190 --> 00:19:16,570
+الناس اللي بيشتغلوا في بنوك الدمبعتوه حتى يعني
+
+208
+00:19:16,570 --> 00:19:23,990
+لأنه معرض ان هو انشك او اشي وصله ال الهو ال ال
+
+209
+00:19:23,990 --> 00:19:29,730
+virus هذا بتاع الكبل وبالتالي انه بعتويا حتى يعمله
+
+210
+00:19:29,730 --> 00:19:38,530
+منع يعمله منع ال ال vaccine الأخير هذا تحت التجربة
+
+211
+00:19:38,530 --> 00:19:46,890
+برضه هذا بياخدوا جزء من ال DNAأه بطريقة اه modern
+
+212
+00:19:46,890 --> 00:19:53,750
+اه molecular biology تاخدوا من ال DNA و من ال
+
+213
+00:19:53,750 --> 00:19:59,870
+virus و بيحقنوه في المريض هذا الصحيح لسه تحت
+
+214
+00:19:59,870 --> 00:20:04,340
+التجربةيعني تحت التجربة have not so far been
+
+215
+00:20:04,340 --> 00:20:09,780
+approved لم يثبت نجاحه في الإنسان عشان هيك ماقلناش
+
+216
+00:20:09,780 --> 00:20:13,360
+إيش هو الفيروس اللي اشتغلوا عليه و نوعه ال DNA
+
+217
+00:20:13,360 --> 00:20:17,860
+vaccine لكن مع الأيام بيبين ان شاء الله الآن يعني
+
+218
+00:20:17,860 --> 00:20:21,480
+أمري أن يكون المحاضرة هذه هيك احنا انتهينا من علم
+
+219
+00:20:21,480 --> 00:20:26,310
+الفيروسات انتهينا من علم الفيروساتوان شاء الله
+
+220
+00:20:26,310 --> 00:20:32,630
+هتكون في محاضرة نتكلم فيها عن ال protozoa اللي هو
+
+221
+00:20:32,630 --> 00:20:37,470
+كائن خاص له بكتيريا وله فيروسات انا بشكركه في
+
+222
+00:20:37,470 --> 00:20:40,550
+نهاية هذه المحاضرة واسأل الله سبحانه وتعالى ان
+
+223
+00:20:40,550 --> 00:20:42,850
+يبارك هذه الجهود وشكرا
+
diff --git a/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/FFXSF330kRQ_raw.srt b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/FFXSF330kRQ_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..1d454f13350e15fb7a04b29f744102a8c5963545
--- /dev/null
+++ b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/FFXSF330kRQ_raw.srt
@@ -0,0 +1,744 @@
+1
+00:00:00,000 --> 00:00:06,720
+الشيطان الرجيم بسم الله الرحمن الرحيم الحمد لله رب
+
+2
+00:00:06,720 --> 00:00:11,620
+العالمين و أصلي و أسلم على النبي الأمين محمد و على
+
+3
+00:00:11,620 --> 00:00:16,640
+آله وأصحابه والتابعين السلام عليكم ورحمة الله
+
+4
+00:00:16,640 --> 00:00:21,520
+وبركاته أعودوا لكم في المحاضرة الرابعة من مساق
+
+5
+00:00:21,520 --> 00:00:25,800
+الأحياء الدقيقة لطلب البصريات الطبية دا إن الله عز
+
+6
+00:00:25,800 --> 00:00:31,660
+وجل أن تكونوا فاستفدتم من محاضرات السلاتةالثلاث
+
+7
+00:00:31,660 --> 00:00:35,520
+السابقة والتي نشرتها على قناة الدكتورة محمد
+
+8
+00:00:35,520 --> 00:00:40,200
+الترشاوي في telegram فعودوا لها واستكملوا الآن
+
+9
+00:00:40,200 --> 00:00:45,460
+المحاضرة الرابعة المحاضرة الرابعة سوف نتكلم عن
+
+10
+00:00:45,460 --> 00:00:52,260
+الأسباب الأسباب البكتيرية ماذا يعني بالأسباب
+
+11
+00:00:52,260 --> 00:01:00,110
+البكتيريةيعني أن البكتيريا لا ترى بيعد المجردة
+
+12
+00:01:00,110 --> 00:01:06,550
+إنما ترى بالميكسكوب لكن حتى بالميكسكوب لا ترى إلا
+
+13
+00:01:06,550 --> 00:01:11,390
+إذا وضعت عليها بعضا من المواد الصابرة صبغات يعني
+
+14
+00:01:11,390 --> 00:01:18,340
+تماما زي ما نقول صبغة الملابسيعني في صبغة حمراء
+
+15
+00:01:18,340 --> 00:01:26,200
+زرقاء سوداء حضراء تصبغ الألوان وتميز فالبكتيريا
+
+16
+00:01:26,200 --> 00:01:31,660
+لما وضعوا عليها بعض الصبغات وجدوا أن هذه الصبغات
+
+17
+00:01:31,660 --> 00:01:37,900
+تميز بين أنواع البكتيريا المختلفة والاصبار
+
+18
+00:01:37,900 --> 00:01:46,330
+هذه في نوعين فيها في أصبار بسيطةها اسمها simple
+
+19
+00:01:46,330 --> 00:01:50,090
+staining وفي
+
+20
+00:01:50,090 --> 00:01:54,390
+أسباب معقدة شوية اسمها differential staining أي
+
+21
+00:01:54,390 --> 00:01:58,710
+الكفيقية التي تفرج يعني في ال simple staining لو
+
+22
+00:01:58,710 --> 00:02:02,010
+المادة الصابغة هذه البسيطة حطيناها كل بكتيريا
+
+23
+00:02:02,010 --> 00:02:06,130
+بتاخد نفس اللون لكن لما حطت differential بتميز
+
+24
+00:02:06,130 --> 00:02:10,090
+الألوان من اللون من بكتيريا بكتيريا حسب اللون اللي
+
+25
+00:02:10,090 --> 00:02:12,230
+بتاخده بالصبغة differential
+
+26
+00:02:16,370 --> 00:02:21,630
+الاسمبال مثل مثلاني بلو مادة كيمية اسمها مثلاني
+
+27
+00:02:21,630 --> 00:02:28,970
+بلو في مادة اسمها سافرانين مثلا فهذه أمثلة مثلاني
+
+28
+00:02:28,970 --> 00:02:34,170
+بلو لو قطعتها البكتيريا بصير لونها أزرق السافرانين
+
+29
+00:02:34,170 --> 00:02:38,070
+لو قطعتها البكتيريا كلها بصير لونها أحمر يعني
+
+30
+00:02:38,070 --> 00:02:42,760
+ماتفرقش تاخد يا كله أزرق يا كله أحمرانما الـ
+
+31
+00:02:42,760 --> 00:02:50,340
+differential لأ بتنيس بين لون و لون ال
+
+32
+00:02:50,340 --> 00:02:55,040
+differential staining فيه نوع علمها نوع ايه اسمه
+
+33
+00:02:55,040 --> 00:03:01,600
+gram stain gram واحد بريطاني هذا هو اكتشف الصبغة
+
+34
+00:03:01,600 --> 00:03:08,180
+وسمها باسمه gram stain الصبغة التانية اسمها zeal
+
+35
+00:03:08,180 --> 00:03:15,090
+nelson stainزيل نيلسون ستين هذا برضه واحد اسمه زيل
+
+36
+00:03:15,090 --> 00:03:21,210
+نيلسون واكتشف صبغة تفريقية سماها باسمه وليكن هذا
+
+37
+00:03:21,210 --> 00:03:29,610
+الكلام بالنسبة لجرام ستين هذا الرجل ميز بين فاصلين
+
+38
+00:03:29,610 --> 00:03:37,190
+كبيرين من البكتيريا واحد موجب واحد سالب سما الموجب
+
+39
+00:03:37,190 --> 00:03:43,910
+جرام positive وسمىالسالب إجرام نيجاتيف يبقى هو
+
+40
+00:03:43,910 --> 00:03:50,810
+يعني عمل حاجة كتيرة إن الإجرام positive عينة
+
+41
+00:03:50,810 --> 00:03:56,250
+لحالها اللي بتاخد اللون الأزرق لشفينه والإجرام
+
+42
+00:03:56,250 --> 00:04:01,650
+negative السالبة اللي بتاخد اللون الأحمر لحاله
+
+43
+00:04:01,650 --> 00:04:08,450
+يبقى هذا إجرام خدمة يعني اكتشف نوعين مختلفين من
+
+44
+00:04:08,450 --> 00:04:08,950
+البكتيريا
+
+45
+00:04:11,520 --> 00:04:20,620
+والاختلاف هذا اختلاف جوهري في الصفقة وفي طريقة
+
+46
+00:04:20,620 --> 00:04:27,460
+الحياة وفي نوع المرض الذي تسببه كل من هذه
+
+47
+00:04:27,460 --> 00:04:33,220
+البكتيريا بل وفي علاج البكتيريا يعني العلاج بتاع
+
+48
+00:04:33,220 --> 00:04:35,880
+ال positive يختلف عن ال negative
+
+49
+00:04:39,130 --> 00:04:46,410
+يبقى إجرام هذا المريطاني قدّم خدمة في اكتشاف هذه
+
+50
+00:04:46,410 --> 00:04:50,810
+الصبرة التفريقية وقال
+
+51
+00:04:50,810 --> 00:04:57,110
+إن الإجرام positive تأخذ اللون الviolet بنفسه أقرب
+
+52
+00:04:57,110 --> 00:05:03,280
+إلى الأزرق بانما الإجرام negative تأخذ الأحمرأه
+
+53
+00:05:03,280 --> 00:05:07,200
+هيا يعني انا في الشكل اللي اضافته جديد هى U هذه
+
+54
+00:05:07,200 --> 00:05:18,560
+تاخد pink color ب I N K يعني لون بنفسه و هذه بتاخد
+
+55
+00:05:18,560 --> 00:05:26,760
+red color يعني لون ايش احمر اللون الاحمر red هذه
+
+56
+00:05:26,760 --> 00:05:29,840
+اجرام نيجاتيب طيب كيف وصل لهذا
+
+57
+00:05:34,220 --> 00:05:41,120
+جالك هو جاب كل البكتيريا و حطها على glass slide
+
+58
+00:05:41,120 --> 00:05:46,020
+ايش يعني glass slide يعني قطعة زجاج شريحة زجاجية
+
+59
+00:05:46,020 --> 00:05:51,580
+هيك اللي بتنحط تحت ال microscope حط بكتيريا من
+
+60
+00:05:51,580 --> 00:05:58,740
+صديق من دم من مغراز من اي سائل من الجسم و هو مش
+
+61
+00:05:58,740 --> 00:06:06,110
+عارف لسه ايش فيهايبقى لما حطها ثبتها على شريحة
+
+62
+00:06:06,110 --> 00:06:15,250
+زجاجية أحط إلها صبغة simple ال
+
+63
+00:06:15,250 --> 00:06:19,310
+simple هذه المرة هذي اسمها crystal virus يعني
+
+64
+00:06:19,310 --> 00:06:23,230
+اسمها إنا بتاع المعمل ال virus يعني بنفسي أقرب
+
+65
+00:06:23,230 --> 00:06:30,550
+لزمان هل الصبغة هذي طبعا مضعبة بالماء يعني الصبغة
+
+66
+00:06:32,480 --> 00:06:39,840
+طلعها ديكتين على اللي هو البكتيريا اللي على شريفة
+
+67
+00:06:39,840 --> 00:06:52,000
+الزجاج طب بعد ديكتين اجى وضع سبيرتو كحول عليها لما
+
+68
+00:06:52,000 --> 00:06:59,000
+حط الكحول عليها الكحول عملت decolorization
+
+69
+00:07:00,910 --> 00:07:06,010
+يعني أزالة اللون اللون الviolet أزالة اللون
+
+70
+00:07:06,010 --> 00:07:16,710
+الviolet صافش لون الخطوة التالتة انه جاب counter
+
+71
+00:07:16,710 --> 00:07:23,490
+stain يعني صبغة مضادة اسمها صفرانين طب مضادة ليه
+
+72
+00:07:23,490 --> 00:07:28,110
+ايش للviolet لcrystal violet مضادة لcrystal violet
+
+73
+00:07:28,110 --> 00:07:34,880
+تحط صفرانين لمدة دقيقتينو إيجى بعدين يكتشف إيجى
+
+74
+00:07:34,880 --> 00:07:44,740
+يكتشف إيش اكتشف؟ اكتشف التل جالك لما حطت crystal
+
+75
+00:07:44,740 --> 00:07:48,560
+violet كل
+
+76
+00:07:48,560 --> 00:07:54,860
+البكتيريا أخدت لون violet إيش violet يعني؟ بنفسي
+
+77
+00:07:54,860 --> 00:07:58,300
+violet كلها أخدت violet
+
+78
+00:08:03,700 --> 00:08:07,900
+اللون اللي كريستال بايلوت هذا باعطي البكتيرا كلها
+
+79
+00:08:07,900 --> 00:08:15,420
+لون واحد سواء هذه ال positive او negative انا
+
+80
+00:08:15,420 --> 00:08:20,560
+الخطوة اللي قلت لأوديين يعني مش ناجج عليها نعيد
+
+81
+00:08:20,560 --> 00:08:23,440
+للخطوة التانية الجهون عمل decolorization
+
+82
+00:08:23,440 --> 00:08:32,310
+decolorization مسح wash يعني مسح ال colorمسح ال
+
+83
+00:08:32,310 --> 00:08:39,490
+color عن واحدة اللي هي هذه وبينما ال positive فضلك
+
+84
+00:08:39,490 --> 00:08:47,530
+فيروس يبقى ال gram positive remain احتورك بال
+
+85
+00:08:47,530 --> 00:08:51,570
+purple او ال virus او ال blue color بينما ال
+
+86
+00:08:51,570 --> 00:08:55,190
+negative صارت colorless اللي هي هذه هذه صارت
+
+87
+00:08:55,190 --> 00:09:01,370
+colorless ال negative بينما ال positive فضلكوهو
+
+88
+00:09:01,370 --> 00:09:08,150
+virus وهذه colorless فهذه الـ negative colorless
+
+89
+00:09:08,150 --> 00:09:14,010
+وال positive احتفظت باللون لأنه أصيل بتاع ال
+
+90
+00:09:14,010 --> 00:09:18,930
+crystal virus الخطوة اللي بعدها جب الكرن فارستين
+
+91
+00:09:18,930 --> 00:09:27,770
+المضاد يعني اسمها سفرانين وحط عكنتين البكتيريا
+
+92
+00:09:27,770 --> 00:09:36,050
+ال positiveهي احتفظت باللون ال virus V والبكتيريا
+
+93
+00:09:36,050 --> 00:09:42,570
+ال نيجاتيب اللي كان لسه بالكفول صارت Red يبقى اخدت
+
+94
+00:09:42,570 --> 00:09:47,490
+لون Red متاع ايش؟ متاع الصبغة ال counter الصبغة ال
+
+95
+00:09:47,490 --> 00:09:52,000
+counter اللي هي صفرانيةيبقى في النهاية انا عندي
+
+96
+00:09:52,000 --> 00:09:59,080
+فصدين gram positive فضل أزرق أو violet بتاع ال
+
+97
+00:09:59,080 --> 00:10:04,040
+crystal violet الأولاني الـ stain الأساسي الـ
+
+98
+00:10:04,040 --> 00:10:10,580
+basic بينما gram negative أخد اللون ال pink أو ال
+
+99
+00:10:10,580 --> 00:10:15,290
+red بتاع ال counter stain السفرانييبقى هذه أخدت
+
+100
+00:10:15,290 --> 00:10:18,670
+السفرانين و هذه فضلك على ال crystal violet ال
+
+101
+00:10:18,670 --> 00:10:22,650
+crystal violet هو لون بنفسه او أزرق و السفرانين
+
+102
+00:10:22,650 --> 00:10:28,370
+لون أحمر يبقى احنا طلعنا ان البكتيريا لجرام نوعين
+
+103
+00:10:28,370 --> 00:10:35,410
+جرام positive و جرام negative وهذا يا بناتي معمول
+
+104
+00:10:35,410 --> 00:10:41,380
+به في المعامل لما احنا بناخدبكتيريا من الدم من
+
+105
+00:10:41,380 --> 00:10:46,120
+مرين أو من البول أو من البراز أو من الصديل أو من
+
+106
+00:10:46,120 --> 00:10:53,100
+أي سائل من الجسم عنده عدوى بكتيريابقول الله وارينا
+
+107
+00:10:53,100 --> 00:11:00,160
+ايش هو هذا الموجود في العينة يعني بيجي بعد ثلاثة
+
+108
+00:11:00,160 --> 00:11:03,400
+اربع ساعت بقول هالي gram positive bacteria نوحة
+
+109
+00:11:03,400 --> 00:11:09,220
+كوكاية نوحة يعني كده نوحة كده او gram negative
+
+110
+00:11:09,220 --> 00:11:13,380
+طبعا ال gram negative المضاد الحيوان اللي بيشتري
+
+111
+00:11:13,380 --> 00:11:18,240
+عليها بختلف عن اللي بيشتري عليه gram positive
+
+112
+00:11:18,240 --> 00:11:25,230
+فالطبيبأو المعالج بيعرف يتصرف يبقى انا ارجع للقصة
+
+113
+00:11:25,230 --> 00:11:31,130
+القصة الان ان ال gram positive تحتفظ بال violet
+
+114
+00:11:31,130 --> 00:11:38,850
+color لأن الكحول لا يزيل اللون لأنه أصلي اللون
+
+115
+00:11:38,850 --> 00:11:43,450
+الأزرق او البنفسة دي أصلي بينما ال gram negative
+
+116
+00:11:45,910 --> 00:11:51,290
+بعد ما أزال عنها الكحول اللون الأزرق أخدت اللون
+
+117
+00:11:51,290 --> 00:11:55,570
+الجديد بتاع السفرانين ال red color بتاع السفرانين
+
+118
+00:11:55,570 --> 00:12:04,170
+وبالتالي صار عندي فاصلين no violet و no red ال
+
+119
+00:12:04,170 --> 00:12:10,370
+violet بتاع الagram positiveهو الـ red telegram
+
+120
+00:12:10,370 --> 00:12:14,370
+بيجيب بيجيب وصار البكتيريا ان عندي فاصلين حسب صبغة
+
+121
+00:12:14,370 --> 00:12:17,930
+ال gram ان شاء الله يكون هذا الكلام واضح وانا من
+
+122
+00:12:17,930 --> 00:12:22,370
+انترنت نزرتلكوا ال slide هذه وهذه مهمة مهمة مهمة
+
+123
+00:12:22,370 --> 00:12:28,170
+سامحكم في ال iodine يعني ال iodine هذا عامل مسهل
+
+124
+00:12:28,170 --> 00:12:33,200
+بسأه عامل مسهل مادة جدا كتير لكن ال crystal violet
+
+125
+00:12:33,200 --> 00:12:39,180
+و الكحول و السفرانين مهمين و لو يعني بتكون تعمل
+
+126
+00:12:39,180 --> 00:12:42,700
+مقارن في الامتحان بالألوان كمان لازم تفضطوا
+
+127
+00:12:42,700 --> 00:12:47,920
+الألوان هذه الألوان هذه تكتب الكلام هذا أرجوك
+
+128
+00:12:47,920 --> 00:12:53,380
+فهيبقونا كمان حسب gram فاصلين gram positive لكبير
+
+129
+00:12:53,380 --> 00:12:57,380
+هذا و gram negative لكبير هذا يعني زي حمولة و
+
+130
+00:12:57,380 --> 00:13:05,500
+حمولةطيب النوع التفريقي الثاني اسمه زيل نيلسون
+
+131
+00:13:05,500 --> 00:13:14,760
+ستين حقيقة هذا لأنواع من البكتيريا يعني قليلة في
+
+132
+00:13:14,760 --> 00:13:18,080
+نوع لا يتعامل مع صبغة جرام
+
+133
+00:13:20,870 --> 00:13:25,070
+هو اللي هيتعمل مصابة جرام بالذات بكتيريا الـ Sol
+
+134
+00:13:25,070 --> 00:13:33,150
+-TB Mycobacterium Tuberculosis الـ TB اللي بتعمل
+
+135
+00:13:33,150 --> 00:13:38,190
+الـ Cell والبكتيريا اللي بتعمل الجذام اللي هو اسمه
+
+136
+00:13:38,190 --> 00:13:43,230
+بكتيريا ليبري ليبري هذه اللي بتعمل الجذام هدولة
+
+137
+00:13:43,230 --> 00:13:46,590
+وجدوا انواعين هدولة بكتيريا الـ TB و بكتيريا
+
+138
+00:13:46,590 --> 00:13:47,510
+ليبروشي
+
+139
+00:13:50,830 --> 00:13:57,390
+لا ينفعها أو لتنصبغ بالجرام فعملولها صبغة اسمها
+
+140
+00:13:57,390 --> 00:14:03,090
+ziel nielsen stain والزيل نيلسون بختلف عن الجرام
+
+141
+00:14:03,090 --> 00:14:08,610
+زيل نيلسون راح مثلا اخد من بتاين ال TB اللي هو
+
+142
+00:14:08,610 --> 00:14:12,630
+السل الرئوي اخد منهم Sputum يعني بلغم غالبا تكون
+
+143
+00:14:12,630 --> 00:14:19,560
+فيه بلغم مع دموحطه في slide برضه وحطه أصدار تختلف
+
+144
+00:14:19,560 --> 00:14:27,980
+الصبغة الأولى اسمها Carbofoxin Carbofoxin لما حطه
+
+145
+00:14:27,980 --> 00:14:36,460
+اعطى اللون الأحمر اعطى اللون الأحمر بعد هيك حط على
+
+146
+00:14:36,460 --> 00:14:41,740
+البكتيريا كثول الكثول مهمته سيعمل decolorization
+
+147
+00:14:41,740 --> 00:14:48,110
+decolorization أي إزالة اللونوجد ان الكحول ازال
+
+148
+00:14:48,110 --> 00:14:56,690
+لون من بكتيريا وخلّاها بيلا لون بينما في لون فضل
+
+149
+00:14:56,690 --> 00:15:02,370
+ثابت احمر مثل الـ Carboxyl ال
+
+150
+00:15:02,370 --> 00:15:08,590
+بكتيريا اللي احتفظت لونها احمر سماها acid fast
+
+151
+00:15:10,780 --> 00:15:15,060
+البكتيريا اللى أزال الكحول عنها اللون الأحمر سماها
+
+152
+00:15:15,060 --> 00:15:25,120
+none as in fast none يعني نفي نفي الان حط counter
+
+153
+00:15:25,120 --> 00:15:31,740
+stain يعني ايش counter stainيعني لون معارض ليه
+
+154
+00:15:31,740 --> 00:15:36,300
+اللي هو ال carbon fucsin حطه مثلين blue وكلمة blue
+
+155
+00:15:36,300 --> 00:15:41,060
+معناها أزرق حط هنا و هنا لجي ان ال acid phos فتجت
+
+156
+00:15:41,060 --> 00:15:45,500
+حمرة و ال bacteria non acid phos اللي بالكحول
+
+157
+00:15:45,500 --> 00:15:51,450
+أصبحت colorless أفدت لون الأزرق فهو الآنزي
+
+158
+00:15:51,450 --> 00:15:57,130
+النيلسون جسم البكاليه لعائلتين عائلة اسمها acid
+
+159
+00:15:57,130 --> 00:16:01,910
+fast وعائلة اسمها non acid fast ال acid fast خمراء
+
+160
+00:16:01,910 --> 00:16:07,310
+و ال non acid fast زرقاء اللون زرقاء اللون زرقاء
+
+161
+00:16:07,310 --> 00:16:10,590
+اللون يبقى أنا عندي نوعين
+
+162
+00:16:13,790 --> 00:16:20,050
+هتفضت بلون الكربون فوكسين على طول وفضت حمراء والنن
+
+163
+00:16:20,050 --> 00:16:26,750
+أسد فاص اللى انتفع عنها لون الكثول واخدت اللون
+
+164
+00:16:26,750 --> 00:16:32,350
+بتاع المثلون الأزرق وثالث زرقاء فانا عندى نوعين
+
+165
+00:16:32,350 --> 00:16:42,680
+أسد فاص حمراء ونن أسد فاص أزرقزرقاء زرقاء قولنا
+
+166
+00:16:42,680 --> 00:16:49,400
+احنا عشان ما ننطش ان ال .. ان زيل نيلسون زيل
+
+167
+00:16:49,400 --> 00:16:57,400
+نيلسون stain هذا لقليل من البكتيريا يعني ليه زي ال
+
+168
+00:16:57,400 --> 00:17:02,360
+gram ال gram هو الأساس هذا لأنواع من البكتيريا
+
+169
+00:17:02,360 --> 00:17:09,100
+ترفضالجرام بس نوعين هما بكتيريا السلد الرئوي و
+
+170
+00:17:09,100 --> 00:17:12,980
+بكتيريا الدودام اللي بري مايكرو بكتيريا اللي بري
+
+171
+00:17:12,980 --> 00:17:19,100
+اللي بتاعنا ليبروسي ليبروسي هو الاش الدودام يبقى
+
+172
+00:17:19,100 --> 00:17:22,680
+انا في المحاضرة هذه ركزت كتير على أصباق البكتيريا
+
+173
+00:17:22,680 --> 00:17:27,460
+ان الأصباق البكتيرية نوعين في أصباق أساسية بقول
+
+174
+00:17:27,460 --> 00:17:32,950
+عنها simple stainو بكتيريا و أصابع تفريقية
+
+175
+00:17:32,950 --> 00:17:37,230
+differential stain ال simple stain زي ال methane
+
+176
+00:17:37,230 --> 00:17:42,370
+ال blue و زي السفرانين و زي الكاربوفوكسين و الحيات
+
+177
+00:17:42,370 --> 00:17:47,350
+هذه بينما ال differential اللي بتخش في جرام و بتخش
+
+178
+00:17:47,350 --> 00:17:53,170
+في زيل نيلسون زيل نيلسون stain زيل نيلسون stain
+
+179
+00:17:53,170 --> 00:17:55,030
+طيب
+
+180
+00:17:59,660 --> 00:18:04,440
+بدي أكتفي أنا الآن يعني بالمحاضرة الصغيرة هذه على
+
+181
+00:18:04,440 --> 00:18:08,860
+أن ألتقيكم في المحاضرة الخامسة اللي هي فيها
+
+182
+00:18:08,860 --> 00:18:14,620
+التعقيم والتطهير التعقيم والتطهير وهذا بيهمنا الآن
+
+183
+00:18:14,620 --> 00:18:19,920
+احنا في وجود الكورونا ايش معنى التعقيم وايش معنى
+
+184
+00:18:19,920 --> 00:18:24,160
+التطهير وان شاء الله قريبا نلتقي والسلام عليكم
+
+185
+00:18:24,160 --> 00:18:27,380
+ورحمة الله وبركاته
+
+186
+00:18:34,360 --> 00:18:35,760
+موسيقى
+
diff --git a/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/HPahig13i8M.srt b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/HPahig13i8M.srt
new file mode 100644
index 0000000000000000000000000000000000000000..538dc2f60d44cc66c4960eb845ab8c5fe3c80fa0
--- /dev/null
+++ b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/HPahig13i8M.srt
@@ -0,0 +1,663 @@
+1
+00:00:00,440 --> 00:00:05,520
+اعوذ بالله من الشيطان الرجيم بسم الله الرحمن
+
+2
+00:00:05,520 --> 00:00:12,000
+الرحيم الحمد لله رب العالمين و أصلي و أسلم على 
+
+3
+00:00:12,000 --> 00:00:17,960
+النبي الأمين بناتي في مادة البصريات الطبية المستوى
+
+4
+00:00:17,960 --> 00:00:24,040
+السادس السلام عليكم ورحمة الله وبركاته كل عام و
+
+5
+00:00:24,040 --> 00:00:31,650
+أنتم بخير في بداية هذا الفصل الأول من العام الدراسي
+
+6
+00:00:31,650 --> 00:00:39,310
+2021 أحييكم بتحية الإسلام والسلام عليكم ورحمة الله 
+
+7
+00:00:39,310 --> 00:00:44,910
+وبركاته وأسأل الله العلي العظيم أن يقدر لنا ولكم 
+
+8
+00:00:44,910 --> 00:00:50,150
+السلامة وأن يخرجنا من هذا الوباء العالمي على خير
+
+9
+00:00:50,150 --> 00:00:58,090
+وأن يجعله كفارة لنا من الذنوب أود أن أبدأ معكم في
+
+10
+00:00:58,090 --> 00:01:03,750
+هذا المساق، مساق الأحياء البسيطة طلبت 
+
+11
+00:01:03,750 --> 00:01:13,410
+العلوم الصحية وخاصة البصريات الطبية هذا العلم علم 
+
+12
+00:01:13,410 --> 00:01:23,020
+جميل ويحمل معاني القدرة الإلهية التي تنبني على أن
+
+13
+00:01:23,020 --> 00:01:28,720
+نرى أشياء لا تراها العين المجردة، أي أنه
+
+14
+00:01:30,870 --> 00:01:35,870
+لا ترى إلا بالـ Microscope المكبر ربما كان
+
+15
+00:01:35,870 --> 00:01:40,910
+Microscope ضوئيا يكبره مئات المرات أو Microscope
+
+16
+00:01:40,910 --> 00:01:48,070
+إلكترونيا يكبره آلاف المرات لذلك سمى Micro Biology
+
+17
+00:01:48,070 --> 00:01:55,230
+Micro دقيق أي لا يرى بالعين و Biology أحياء فهي
+
+18
+00:01:55,230 --> 00:02:02,190
+الأحياء الدقيقة أي التي لا ترى بالعين المجردة وفي
+
+19
+00:02:02,190 --> 00:02:11,830
+هذا السياق عدت لكم بمساق مبسطة بدأت بالتعريف بال
+
+20
+00:02:11,830 --> 00:02:18,050
+micro biology أنه فرع من الأحياء الدقيقة هو فرع من 
+
+21
+00:02:18,050 --> 00:02:21,590
+الأحياء الدقيقة يعني الأحياء الدقيقة اسمها biology
+
+22
+00:02:21,590 --> 00:02:26,980
+أو علم الأحياء اسمه biology، الأحياء الدقيقة اسمها
+
+23
+00:02:26,980 --> 00:02:32,400
+microbiology التي لا ترى إلا بالعين المجردة بيقول
+
+24
+00:02:32,400 --> 00:02:35,700
+أنه dealing with microscopic forms of living
+
+25
+00:02:35,700 --> 00:02:42,680
+organisms أي أنه يتناول الأحياء التي لا ترى إلا 
+
+26
+00:02:42,680 --> 00:02:48,420
+بالمايكروسكوب هي أحياء لا ترى إلا بالمايكروسكوب ولا
+
+27
+00:02:48,420 --> 00:02:52,360
+ترى بالعين المجردة naked eye يعني العين المجردة، آه
+
+28
+00:02:52,360 --> 00:02:57,080
+ولكنها ترى بالمايكروسكوب المكبر magnifying microscope
+
+29
+00:02:57,080 --> 00:03:03,480
+magnifying يعني مكبر و magnifying يعني مخغر، ال
+
+30
+00:03:03,480 --> 00:03:10,340
+bacteriology هو أحد فروع هذا العلم، وال biology أحد 
+
+31
+00:03:10,340 --> 00:03:13,860
+فروع هذا العلم، وprotodology أحد فروع هذا العلم
+
+32
+00:03:13,860 --> 00:03:18,360
+يعني الأحياء الدقيقة microbiology تحتوي على علوم
+
+33
+00:03:18,360 --> 00:03:25,320
+زي ال bacteriology و ال biology و protodology، الآن
+
+34
+00:03:25,320 --> 00:03:30,360
+في عجلة سنتكلم على characteristics of
+
+35
+00:03:30,360 --> 00:03:36,060
+microorganism، إيش يعني ب characteristics يعني ما
+
+36
+00:03:36,060 --> 00:03:41,170
+هي خصائص الأحياء الدقيقة، خصائص الأحياء الدقيقة يعني
+
+37
+00:03:41,170 --> 00:03:46,870
+أقدر أنا أُجملها، أولاً أنها living creatures أي هي
+
+38
+00:03:46,870 --> 00:03:54,450
+مخلوقات حية، مخلوقات حية أي أنها تتحرك أي أنها 
+
+39
+00:03:54,450 --> 00:04:02,230
+تتنفس، أنها تتغذى، و أنها تتكاثر، و أنها تثير، يبقى 
+
+40
+00:04:02,230 --> 00:04:05,070
+واحد living creatures، Creatures يعني مخلوقات
+
+41
+00:04:05,850 --> 00:04:11,170
+microscopic in size يعني هي مجهرية أي لا ترى إلا
+
+42
+00:04:11,170 --> 00:04:16,070
+بالمايكروسكوب وهي unicellular وأعني بالـ 
+
+43
+00:04:16,070 --> 00:04:21,690
+unicellular وحيدة الخلايا يعني أي أن الكائن
+
+44
+00:04:21,690 --> 00:04:26,650
+الحي هذا هو يتكون من خلية واحدة لا أكثر، هذه الخلية
+
+45
+00:04:26,650 --> 00:04:35,440
+تحتوي على كل وظائف الكائن الحي، الخاصية الرابعة أنها
+
+46
+00:04:35,440 --> 00:04:41,060
+قادرة هذه الخلية على ال growth النمو and 
+
+47
+00:04:41,060 --> 00:04:45,460
+multiplication والتكاثر، يبقى قادرة على النمو 
+
+48
+00:04:45,460 --> 00:04:55,160
+وقادرة على التكاثر، الخاصية الخامسة للأحياء الدقيقة
+
+49
+00:04:55,160 --> 00:05:02,870
+أنها تحتوي على ثماني مجموعات، ثماني مجموعات، سنترخ 
+
+50
+00:05:02,870 --> 00:05:08,750
+فقط نحن إلى ثلاثة منها، سنترخ إلى بكتيريا واحدة، إلى 
+
+51
+00:05:08,750 --> 00:05:13,190
+بروتوزوا اثنتين، وإلى ال viruses، ال viruses ثلاثة
+
+52
+00:05:13,190 --> 00:05:18,130
+يبقى هم ثمان عائلات من الأحياء الدقيقة نحن سنتكلم عن
+
+53
+00:05:18,130 --> 00:05:22,490
+ثلاث عائلات فقط منها هي البكتيريا، البروتوزوا، و ال
+
+54
+00:05:22,490 --> 00:05:30,390
+viruses، ال viruses نبدأ بالبكتيريا، البكتيريا هي
+
+55
+00:05:30,390 --> 00:05:39,830
+أحياء مايكروسكوبية، هي 
+
+56
+00:05:39,830 --> 00:05:42,930
+أحياء
+
+57
+00:05:42,930 --> 00:05:48,610
+مايكروسكوبية، يعني البكتيريا أحياء مايكروسكوبية
+
+58
+00:05:48,610 --> 00:05:53,150
+بدائية Prokaryotic، Prokaryotic يعني بدائية 
+
+59
+00:05:53,150 --> 00:05:56,130
+البكتيريا
+
+60
+00:05:56,940 --> 00:06:01,720
+ما هي خصائص البكتيريا العامة؟ إيش بقول عامة؟ لأن في
+
+61
+00:06:01,720 --> 00:06:05,980
+بكتيريا، أنواع البكتيريا لها خصائص خاصة، هتكلم على
+
+62
+00:06:05,980 --> 00:06:12,520
+الخصائص العامة للبكتيريا، أول خاصية عامة للبكتيريا
+
+63
+00:06:12,520 --> 00:06:21,460
+أنها لها نواة nucleus يعني نواة، هذه النواة ليس لها
+
+64
+00:06:21,460 --> 00:06:26,660
+غشاء نووي ولا لها نوية يعني بدون غشاء نووي وبدون 
+
+65
+00:06:26,660 --> 00:06:36,180
+نوية، الإنسان ككائن راقي النواة لها ملحق اسمه نوية
+
+66
+00:06:36,180 --> 00:06:42,420
+أو نويات، ولها غشاء اسمه Nuclear Membrane، لكن 
+
+67
+00:06:42,420 --> 00:06:48,120
+البكتيريا لأنها Prokaryotic بداية يعني، بيقول أنّه مش
+
+68
+00:06:48,120 --> 00:06:55,120
+متطورة، ليس لها غشاء نووي ولا لها نوية، هذه تحتوي 
+
+69
+00:06:55,120 --> 00:07:02,760
+على حمضين نوويين Nuclear acids، أحماض نوية، النواة
+
+70
+00:07:02,760 --> 00:07:07,540
+فيها أحماض نوية DNA وRNA، و أنا المفروض أن أكون كتبت
+
+71
+00:07:07,540 --> 00:07:10,100
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+72
+00:07:10,100 --> 00:07:13,220
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+73
+00:07:13,220 --> 00:07:18,880
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+74
+00:07:18,880 --> 00:07:22,120
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+75
+00:07:22,120 --> 00:07:23,880
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+76
+00:07:23,880 --> 00:07:24,140
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+77
+00:07:24,140 --> 00:07:24,180
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+78
+00:07:24,180 --> 00:07:24,260
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+79
+00:07:24,260 --> 00:07:33,700
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+80
+00:07:33,700 --> 00:07:39,670
+DNA DNA DNA، البكتيريا تقسم إلى أنها بكتيريا سفلية
+
+81
+00:07:39,670 --> 00:07:43,430
+أو دنيئة، وبكتيريا high، بكتيريا يعني راقية شوية
+
+82
+00:07:43,430 --> 00:07:52,710
+البكتيريا الدنيئة ممكن تكون كوروية أو بيضاوية
+
+83
+00:07:52,710 --> 00:08:00,010
+rounded or oval، ال rounded اسمها كوكاي، كوكاي اللي
+
+84
+00:08:00,010 --> 00:08:00,870
+هو rounded
+
+85
+00:08:13,200 --> 00:08:19,680
+البكتيريا الدنيئة لها ثلاث أشكال: إما كوكاي أو
+
+86
+00:08:19,680 --> 00:08:27,200
+باسلاي أو حلزونية، الحلزونية، الهاي بكتيريا لأ
+
+87
+00:08:27,200 --> 00:08:32,140
+مبتعمل خيوط تتصل ببعضها البعض في خيوط ملتوية اسمها 
+
+88
+00:08:32,140 --> 00:08:35,420
+filamentous بكتيريا، filamentous بكتيريا، وهذه
+
+89
+00:08:35,420 --> 00:08:39,180
+الخيوط قد تكون متشعبة، قد تكون متشعبة، نشوف
+
+90
+00:08:39,180 --> 00:08:43,940
+البكتيريا اللي هو الدنيئة هي كوكاي كوروية، و باسلاي
+
+91
+00:08:43,940 --> 00:08:47,180
+عَطوية، وهي ال spiral، هذه البكتيريا الدنيئة اللي 
+
+92
+00:08:47,180 --> 00:08:51,850
+هقولنا عنها قبل قليل، البكتيريا الأعلى لأ يعني ممكن 
+
+93
+00:08:51,850 --> 00:08:56,370
+نلاقي فيها يعني، بكتيريا قولنا filamentous بكتيريا 
+
+94
+00:08:56,370 --> 00:09:01,610
+filamentous بكتيريا يعني بكتيريا في خيوط زي ال
+
+95
+00:09:01,610 --> 00:09:05,690
+spiral case مثلًا زي الديدان هيك طويلة انطوالة، فهذه
+
+96
+00:09:05,690 --> 00:09:10,650
+اسمها higher bacteria، الخاصية
+
+97
+00:09:10,650 --> 00:09:17,610
+الثانية ليه البكتيريا أنها هي ال unicellular يعني
+
+98
+00:09:17,610 --> 00:09:27,640
+وحيدة الخلية، آه، لكنها قد تعيش في سلاسل بكتيريا أو
+
+99
+00:09:27,640 --> 00:09:34,980
+في قطوف أو عناقيد، لكن داخل القطوف أو داخل الخيوط
+
+100
+00:09:34,980 --> 00:09:39,860
+و السلاسل كل خلية تعتبر عن نفسها يعني تمامًا زي أنا
+
+101
+00:09:39,860 --> 00:09:44,980
+مجيب حبة عنب لحالها، حبة العنب هي حبة عنب، إلها قشرة
+
+102
+00:09:44,980 --> 00:09:54,020
+وإلها لب و إلها بذرات، و أجيب عنقود فيه مائة حبة عنب، لا
+
+103
+00:09:54,020 --> 00:09:58,640
+يعني أن المائة حبة عنب أنهم حبة واحدة، إنما هم مائة
+
+104
+00:09:58,640 --> 00:10:02,980
+حبة، كل حبة إلها كيان مستقل، لكن هم مدمجين في
+
+105
+00:10:02,980 --> 00:10:08,440
+cluster، ال cluster عنقود، فالبكتيريا قد تعيش في 
+
+106
+00:10:08,440 --> 00:10:14,800
+عناقيد زي احنا ما شوفنا هنا هيها، هذه عناقيد بكتيريا 
+
+107
+00:10:14,800 --> 00:10:23,290
+عناقيد بكتيريا، و قد تعيش في خليتين، و قد تعيش خلية
+
+108
+00:10:23,290 --> 00:10:28,530
+واحدة زي هذا الشكل لكي تكون خلية واحدة، و الباسلي اللي
+
+109
+00:10:28,530 --> 00:10:31,550
+هي نفس الشيء يمكن تكون عود لحالها أو عدة عيدان، و ال .. و ال .. و ال spiral قد تكون يعني spiral
+
+110
+00:10:31,550 --> 00:10:35,690
+واحدة أو عدة spirals، طيب، الخاصية الرابعة 
+
+111
+00:10:35,690 --> 00:10:40,750
+علاقة البكتيريا بالكائن الذي تعيش فيه يعني
+
+112
+00:10:44,360 --> 00:10:50,460
+البكتيريا طفيلية تعيش في الإنسان، في الحيوان، في 
+
+113
+00:10:50,460 --> 00:10:54,800
+النبات، فما هي العلاقة؟ العلاقة أنها تعيش
+
+114
+00:11:01,140 --> 00:11:07,720
+parasitic life أي حياة طفيلية تتطفل على ال host، ال
+
+115
+00:11:07,720 --> 00:11:13,980
+host هو العائل المضيف، وهذا العائل قد يكون man يعني
+
+116
+00:11:13,980 --> 00:11:20,180
+إنسان أو animal اللي هو حيوان أو plant، plant يعني
+
+117
+00:11:20,180 --> 00:11:26,940
+نبات، فيه يعني بكتيريا بتعيش في النبات، و تتكاثر في
+
+118
+00:11:26,940 --> 00:11:33,400
+النبات، كثير من أنواع البكتيريا commensals
+
+119
+00:11:33,400 --> 00:11:39,800
+commensals أي متعايشة، وقد تكون مفيدة للإنسان، كيف
+
+120
+00:11:39,800 --> 00:11:45,490
+يعني؟ يعني مثلًا في بكتيريا بتعيش على الجلد، تتغذى 
+
+121
+00:11:45,490 --> 00:11:51,290
+من العرق بس، من عرقنا، ولا تحدث أي أمراض، في بكتيريا
+
+122
+00:11:51,290 --> 00:11:55,170
+تعيش في الأمعاء، تتغذى على فضلات البراضي، ولا تحدث 
+
+123
+00:11:55,170 --> 00:11:58,790
+أي أمراض، في بكتيريا بتعيش في شعرنا، بتعيش على
+
+124
+00:11:58,790 --> 00:12:02,590
+القشور في شعرنا، لا تحدث أي أمراض، تتغذى على الفضلات 
+
+125
+00:12:02,590 --> 00:12:07,830
+الصغيرة، فهذه بقولنا commensal، لكن إيش الخطر منها؟ الخطر
+
+126
+00:12:07,830 --> 00:12:14,760
+منها أنه إذا ضعف العائل أو مناعة العائل ضعفت لسبب من 
+
+127
+00:12:14,760 --> 00:12:19,180
+الأسباب، فإن هذه الـ commensal تصبح pathogenic تنقلب
+
+128
+00:12:19,180 --> 00:12:23,620
+إلى pathogenic وتغزو داخل الجسم وتفتك به، فهي 
+
+129
+00:12:23,620 --> 00:12:29,620
+متعايشة بفعل يعني أن الإنسان العائل قوي ومنعته
+
+130
+00:12:29,620 --> 00:12:35,880
+قوية لا تستطيع أن تخترقها فتتغذى على الفضلات، أما
+
+131
+00:12:35,880 --> 00:12:41,780
+إذا اختلت المعادلة وضعفت اللي هو رصيده الإنسان من 
+
+132
+00:12:41,780 --> 00:12:48,120
+المناعة فإنها تهاجمه وتفتك به وتصبح pathogenic، تصبح
+
+133
+00:12:48,120 --> 00:12:52,540
+إيش؟ pathogenic، لذا احنا ميزنا العلاقة بين 
+
+134
+00:12:52,540 --> 00:12:57,380
+البكتيريا والعائل أنها قد تكون pathogenic مرضية أو 
+
+135
+00:12:57,380 --> 00:13:03,050
+تكون commensal متعايشة ولا تحدث مرضًا إلا في حالات 
+
+136
+00:13:03,050 --> 00:13:11,590
+خاصة وهي أن يحدث مرض أو نقص مناعي عند هذا العائل
+
+137
+00:13:11,590 --> 00:13:14,490
+عند هذا العائل، طبعًا كثير من البكتيريا بتعيش في 
+
+138
+00:13:14,490 --> 00:13:18,890
+الأمعاء تولد لنا فيتامينات تساعدنا في قتل
+
+139
+00:13:18,890 --> 00:13:22,750
+البكتيريا المرضية، وإذا غابت البكتيريا المتعايشة من 
+
+141
+00:13:22,750 --> 00:13:26,410
+الأمعاء فإن البكتيريا المرضية تحل وقد تفتك به
+
+142
+00:13:26,410 --> 00:13:31,660
+اللي هو القولون والجهاز الهضمي، الخاصية الخامسة
+
+143
+00:13:31,660 --> 00:13:39,780
+للبكتيريا عموما أنها تتكاثر لا جنسيا يعني ما فيش
+
+144
+00:13:39,780 --> 00:13:45,480
+بكتيريا ذكر وبكتيريا أنثى كالحيوان والإنسان لا
+
+145
+00:13:45,480 --> 00:13:51,200
+إنما تتكاثر بالانقسام الثنائي البسيط simple
+
+146
+00:13:51,200 --> 00:13:55,280
+division اسمه binary fission الانقسام الثنائي 
+
+147
+00:13:55,280 --> 00:14:01,640
+البسيط وهو أن الخلية تنقسم إلى خليتين والخليتين إلى 
+
+148
+00:14:01,640 --> 00:14:06,400
+أربع والاربع إلى ثماني وهكذا هذا اسمه انقسام ثنائي
+
+149
+00:14:06,400 --> 00:14:13,100
+بسيط وأنا الآن أوريكم الصورة انقسام ثنائي بسيط
+
+150
+00:14:13,100 --> 00:14:19,500
+هذه الصورة انقسام ثنائي بسيط الدقيقة صفر كانت 
+
+151
+00:14:19,500 --> 00:14:24,560
+واحدة بعد عشرين دقيقة عشرين minutes صاروا اثنين بعد 
+
+152
+00:14:24,560 --> 00:14:30,540
+أربعين دقيقة صاروا أربعة بعد ستين دقيقة
+
+153
+00:14:30,540 --> 00:14:38,740
+صاروا ثمانية طيب لو قلت بعد ثمانين دقيقة حصروا كم؟
+
+154
+00:14:38,740 --> 00:14:46,620
+ستة عشر بعد مئة دقيقة حصروا ستة وثلاثين وهكذا
+
+155
+00:14:46,620 --> 00:14:49,880
+يبقى هذا اسمه انقسام ثنائي بسيط أي أن كل خلية
+
+156
+00:14:49,880 --> 00:14:55,520
+تنقسم إلى اثنتين عندما تنمو وتكبر واثنتين نقسم إلى
+
+157
+00:14:55,520 --> 00:15:00,640
+أربع وهكذا انقسام ثنائي بسيط هذه من خصائص
+
+158
+00:15:00,640 --> 00:15:06,320
+البكتيريا العامة خصائص البكتيريا العامة
+
+159
+00:15:12,910 --> 00:15:17,430
+هو انقسام ثنائي بسيط حيث بتقوم الخلية الأم
+
+160
+00:15:17,430 --> 00:15:21,710
+بالانقسام إلى خليتين اسمها daughter cells البنات
+
+161
+00:15:21,710 --> 00:15:27,130
+الخلية البنات والخلية البنات لما تنمو بنقسم كل
+
+162
+00:15:27,130 --> 00:15:29,990
+واحدة إلى اثنين ومع الوقت بيعملوا colonies
+
+163
+00:15:29,990 --> 00:15:35,950
+bacteria الـ colonies هي مستعمرات بكتيريا في بعضها
+
+164
+00:15:35,950 --> 00:15:41,330
+بيعيش في قطوف وبعضها بيعيش في قيوب بيعيش في قيوب
+
+165
+00:15:42,650 --> 00:15:47,610
+أنا هأتوقف الآن يعني في هذه المحاضرة المقدمة أنا
+
+166
+00:15:47,610 --> 00:15:52,950
+بأعتبرها هذه المحاضرة مقدمة تستوعبوها إن شاء الله
+
+167
+00:15:52,950 --> 00:15:56,950
+وسنكمل فيما بعد والسلام عليكم ورحمة الله 
diff --git a/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/HPahig13i8M_raw.json b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/HPahig13i8M_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..afa8b295172572233b2273a625c0b2693fd9701e
--- /dev/null
+++ b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/HPahig13i8M_raw.json
@@ -0,0 +1 @@
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يتناول الاحياء التي لا ترى الا بالمايكسكوب هي احياء لا ترى الا بالمايكسكوب ولا ترى بالعين المجردة naked eye يعني العين المجردة", "tokens": [6027, 39319, 1829, 16606, 32748, 38436, 28671, 24525, 2304, 11296, 33234, 1793, 38392, 20193, 6055, 2288, 7578, 42963, 20666, 3615, 9957, 9673, 7435, 2288, 41891, 4724, 1829, 39648, 16472, 3224, 6260, 365, 47897, 6422, 295, 2647, 22110, 1975, 1829, 16472, 3224, 7251, 2655, 8315, 12610, 2423, 39319, 1829, 16606, 38392, 20193, 6055, 2288, 7578, 42963, 20666, 15042, 1829, 4117, 3794, 4117, 37746, 39896, 1975, 5016, 1829, 16606, 20193, 6055, 2288, 7578, 42963, 20666, 15042, 1829, 4117, 3794, 4117, 37746, 49429, 6055, 2288, 7578, 20666, 3615, 9957, 9673, 7435, 2288, 41891, 15791, 3313, 37495, 22653, 18863, 9957, 9673, 7435, 2288, 41891], "avg_logprob": -0.15818379303016286, "compression_ratio": 2.0597014925373136, "no_speech_prob": 0.0, "words": [{"start": 145.68, "end": 146.22, "word": "الاحياء", "probability": 0.906982421875}, {"start": 146.22, "end": 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/HPahig13i8M_raw.srt b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/HPahig13i8M_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..5b28adfe04e48a29702cbc106ee10a0ccb90240c
--- /dev/null
+++ b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/HPahig13i8M_raw.srt
@@ -0,0 +1,700 @@
+1
+00:00:00,440 --> 00:00:05,520
+عوض من الله من الشيطان الرجيم بسم الله الرحمن
+
+2
+00:00:05,520 --> 00:00:12,000
+الرحيم الحمد لله رب العالمين و أصلي و أسلم على
+
+3
+00:00:12,000 --> 00:00:17,960
+النبي الأمين بناتي في خصم البصريات الطبية المستوى
+
+4
+00:00:17,960 --> 00:00:24,040
+السادس السلام عليكم و رحمة الله وبركاته كل عام و
+
+5
+00:00:24,040 --> 00:00:31,650
+أنتم بخير في بداية هذا الفصلالأول من العام الدراسي
+
+6
+00:00:31,650 --> 00:00:39,310
+2021 أحييكم بتحية الإسلام والسلام عليكم ورحمة الله
+
+7
+00:00:39,310 --> 00:00:44,910
+وبركاته وأسأل الله العلي العظيم أن يقدر لنا ولكم
+
+8
+00:00:44,910 --> 00:00:50,150
+السلامة وأن يخرجنا من هذا الوباء العالمي على خير
+
+9
+00:00:50,150 --> 00:00:58,090
+وأن نجعله كفارة لنا من الذنوب أود أن أبدأ معكمفي
+
+10
+00:00:58,090 --> 00:01:03,750
+هذا المسافة الشيخ مسافة الأحياء البسيطة طلبت
+
+11
+00:01:03,750 --> 00:01:13,410
+العلوم الصحية وخاصة البصريات التدبية هذا العلم علم
+
+12
+00:01:13,410 --> 00:01:23,020
+جميل ويحمل معاني القدرة الإلهيةالتي تنبني على أن
+
+13
+00:01:23,020 --> 00:01:28,720
+نرى أشياء لا تراها العين المجردة، أي أنه
+
+14
+00:01:30,870 --> 00:01:35,870
+لا ترى إلا بالـ Microscope المكبر ربما كان
+
+15
+00:01:35,870 --> 00:01:40,910
+Microscope ضوئيا يكبره مئات المرات أو Microscope
+
+16
+00:01:40,910 --> 00:01:48,070
+إلكترونيا يكبره آلاف المرات لذلك سمى Micro Biology
+
+17
+00:01:48,070 --> 00:01:55,230
+Micro دقيق أي لا يرى بالعين و Biology أحياء فهي
+
+18
+00:01:55,230 --> 00:02:02,190
+الأحياء الدقيقة أي التي لا ترى بالعين المجردةوفي
+
+19
+00:02:02,190 --> 00:02:11,830
+هذا السياق عدت لكم مساقة مبسطة بدأت بالتعريف بال
+
+20
+00:02:11,830 --> 00:02:18,050
+micro biology أنه فرع من الأحياء الدقيقة هو فرع من
+
+21
+00:02:18,050 --> 00:02:21,590
+الأحياء الدقيقة يعني الأحياء الدقيقة اسمها biology
+
+22
+00:02:21,590 --> 00:02:26,980
+او علم الأحياء اسمه biologyالاحياء الدقيقة اسمها
+
+23
+00:02:26,980 --> 00:02:32,400
+microbiology التي لا ترى الا بالعين المجردة بيقول
+
+24
+00:02:32,400 --> 00:02:35,700
+انه dealing with microscopic forms of living
+
+25
+00:02:35,700 --> 00:02:42,680
+organisms اي انه يتناول الاحياء التي لا ترى الا
+
+26
+00:02:42,680 --> 00:02:48,420
+بالمايكسكوب هي احياء لا ترى الا بالمايكسكوب ولا
+
+27
+00:02:48,420 --> 00:02:52,360
+ترى بالعين المجردة naked eye يعني العين المجردةأه
+
+28
+00:02:52,360 --> 00:02:57,080
+ولكنها ترى بالميكسكوب المكبر magnifying microscope
+
+29
+00:02:57,080 --> 00:03:03,480
+magnifying يعني مكبر و magnifying يعني مخغر ال
+
+30
+00:03:03,480 --> 00:03:10,340
+bacteriology هو أحد فروع هذا العلم وال biologyأحد
+
+31
+00:03:10,340 --> 00:03:13,860
+فروح هذا العلم وprotodology أحد فروح هذا العلم
+
+32
+00:03:13,860 --> 00:03:18,360
+يعني الأحياء الدقيقة microbiology تحتوي على علوم
+
+33
+00:03:18,360 --> 00:03:25,320
+زي ال bacteriology و ال biology و protodology الآن
+
+34
+00:03:25,320 --> 00:03:30,360
+في عجلة سنتكلم على characteristics of
+
+35
+00:03:30,360 --> 00:03:36,060
+microorganism ايش يعني ب characteristics يعني ما
+
+36
+00:03:36,060 --> 00:03:41,170
+هي خصائصالأحياء الدقيقة قصائص الأحياء الدقيقة يعني
+
+37
+00:03:41,170 --> 00:03:46,870
+اقدر انا اجملها اولا انه living creatures اي هي
+
+38
+00:03:46,870 --> 00:03:54,450
+مخلوقات حية مخلوقات حية اي انها تتحرك اي انها
+
+39
+00:03:54,450 --> 00:04:02,230
+تتنفس انها تتغذى و انها تتكاثر و انها تثير يبقى
+
+40
+00:04:02,230 --> 00:04:05,070
+واحد living creatures Creatures يعني مخلوقات
+
+41
+00:04:05,850 --> 00:04:11,170
+microscopic incise يعني هي مجهرية أي لا ترى إلا
+
+42
+00:04:11,170 --> 00:04:16,070
+بالمايكروسكوب وهي unicellular وأعني بالـ
+
+43
+00:04:16,070 --> 00:04:21,690
+unicellular وحيرة الخلايا يعني أي أن الكائن
+
+44
+00:04:21,690 --> 00:04:26,650
+الذاتير هو يتكون من خلية واحدة لا أكتر هذه الخلية
+
+45
+00:04:26,650 --> 00:04:35,440
+تحتوي على كل وضائف الكائن الحيالخاصية الرابعة انه
+
+46
+00:04:35,440 --> 00:04:41,060
+قادرة هذه الخلية على ال growth النمو and
+
+47
+00:04:41,060 --> 00:04:45,460
+multiplication والتكاتر يبقى قادرة على النمو
+
+48
+00:04:45,460 --> 00:04:55,160
+وقادرة على التكاتر الخاصية الخامسة للأحياء الدقيقة
+
+49
+00:04:55,160 --> 00:05:02,870
+ان هي تحتوي على ثماني مجموعات ثماني مجموعاتسنترخ
+
+50
+00:05:02,870 --> 00:05:08,750
+فقط نحن إلى ثلاثة منها سنترخ إلى بكتيريا واحد إلى
+
+51
+00:05:08,750 --> 00:05:13,190
+بروتوزوه اتنين وإلى ال viruses ال viruses ثلاثة
+
+52
+00:05:13,190 --> 00:05:18,130
+يبقى هم ثمان عائلات على حياتي دقيقة نحن سنتكلم عن
+
+53
+00:05:18,130 --> 00:05:22,490
+ثلاث عائلات فقط منها هي البكتيريا البروتوزوه و ال
+
+54
+00:05:22,490 --> 00:05:30,390
+viruses ال viruses نبدأ بالبكتيريا البكتيرياهي
+
+55
+00:05:30,390 --> 00:05:39,830
+أحياء مايكروسكوية هي
+
+56
+00:05:39,830 --> 00:05:42,930
+أحياء
+
+57
+00:05:42,930 --> 00:05:48,610
+مايكروسكوية يعني البكتيريا أحياء مايكروسكوية
+
+58
+00:05:48,610 --> 00:05:53,150
+بدائية Prokaryotic Prokaryotic يعني بدائية
+
+59
+00:05:53,150 --> 00:05:56,130
+البكتيريا
+
+60
+00:05:56,940 --> 00:06:01,720
+ما هي خصائص البكتيريا العامة ايش بقول عامة لأن في
+
+61
+00:06:01,720 --> 00:06:05,980
+بكتيريا انواع البكتيريا لها خصائص خاصة هتكلم على
+
+62
+00:06:05,980 --> 00:06:12,520
+الخصائص العامة للبكتيريا اول خاصية عامة للبكتيريا
+
+63
+00:06:12,520 --> 00:06:21,460
+انها لها نواة nucleus يعني نواة هذه النواةليس لها
+
+64
+00:06:21,460 --> 00:06:26,660
+غشاء نوي ولا لها نوية يعني بدون غشاء نوي و بدون
+
+65
+00:06:26,660 --> 00:06:36,180
+نوية الانسان ككائن راقي النواء لها ملحق اسم نوية
+
+66
+00:06:36,180 --> 00:06:42,420
+او نوياتولها غشاء اسمه Nuclear Membrane لكن
+
+67
+00:06:42,420 --> 00:06:48,120
+البكتيريا لأنها Prokaryotic بداية يعني مقول انه مش
+
+68
+00:06:48,120 --> 00:06:55,120
+متطورة ليس لها غشاء نووي ولا إلها نوية هذه تحتوي
+
+69
+00:06:55,120 --> 00:07:02,760
+على حمضين نوويين Nuclear acids أحمار نوية النوية
+
+70
+00:07:02,760 --> 00:07:07,540
+فيها أحمار نويةDNA وRNA وانا المفروض ان اكون كتبت
+
+71
+00:07:07,540 --> 00:07:10,100
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+72
+00:07:10,100 --> 00:07:13,220
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+73
+00:07:13,220 --> 00:07:18,880
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+74
+00:07:18,880 --> 00:07:22,120
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+75
+00:07:22,120 --> 00:07:23,880
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+76
+00:07:23,880 --> 00:07:23,880
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+77
+00:07:23,880 --> 00:07:24,140
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+78
+00:07:24,140 --> 00:07:24,140
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+79
+00:07:24,140 --> 00:07:24,140
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+80
+00:07:24,140 --> 00:07:24,140
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+81
+00:07:24,140 --> 00:07:24,140
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+82
+00:07:24,140 --> 00:07:24,140
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+83
+00:07:24,140 --> 00:07:24,140
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+84
+00:07:24,140 --> 00:07:24,140
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+85
+00:07:24,140 --> 00:07:24,180
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+86
+00:07:24,180 --> 00:07:24,260
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+87
+00:07:24,260 --> 00:07:33,700
+DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA
+
+88
+00:07:33,700 --> 00:07:39,670
+DNA DNA DNAالبكتيريا ترقسم إلى انها بكتيريا سفلية
+
+89
+00:07:39,670 --> 00:07:43,430
+او دنيئة وبكتيريا high بكتيريا يعني رافية شوية
+
+90
+00:07:43,430 --> 00:07:52,710
+البكتيريا الدنيئة ممكن تكون كوروية او بيضاوية
+
+91
+00:07:52,710 --> 00:08:00,010
+rounded or oval ال rounded اسمها كوكاى كوكاى اللي
+
+92
+00:08:00,010 --> 00:08:00,870
+هو rounded
+
+93
+00:08:13,200 --> 00:08:19,680
+البكتيريا الدنيئة لها ثلاث أشكال اما كوكاي او
+
+94
+00:08:19,680 --> 00:08:27,200
+باسلاي او حلوزونيةالحلزونية الهاي بكتيريا لأ
+
+95
+00:08:27,200 --> 00:08:32,140
+مبتمال خيوط تتصل بعض ببعض في خيوط ملتوية اسمها
+
+96
+00:08:32,140 --> 00:08:35,420
+filamentous بكتيريا filamentous بكتيريا وهذه
+
+97
+00:08:35,420 --> 00:08:39,180
+الخيوط قد تكون متشعبة قد تكون متشعبة نشوف
+
+98
+00:08:39,180 --> 00:08:43,940
+البكتيريا اللي هو الدنيئة هي كوكاي كوروية وباطلهاي
+
+99
+00:08:43,940 --> 00:08:47,180
+عطوية وهي ال spiral هذه البكتيريا الدنيئة اللي
+
+100
+00:08:47,180 --> 00:08:51,850
+هقولنا عنها قبل قليلالبكتيريا الأعلى لأ يعني ممكن
+
+101
+00:08:51,850 --> 00:08:56,370
+نلاقي فيها يعني بكتيريا قولنا filamentous بكتيريا
+
+102
+00:08:56,370 --> 00:09:01,610
+filamentous بكتيريا يعني بكتيريا في خيور زي ال
+
+103
+00:09:01,610 --> 00:09:05,690
+spiral case مثلا زي الديدان هيك طويلة انطاولة فهذه
+
+104
+00:09:05,690 --> 00:09:10,650
+اسمها higher bacteria الخاصية
+
+105
+00:09:10,650 --> 00:09:17,610
+التانية ليه البكتيريا انه هي ال unicellular يعني
+
+106
+00:09:17,610 --> 00:09:27,640
+وحيدة الخليةأه لكنها قد تعيش في سلاسل بكتيريا أو
+
+107
+00:09:27,640 --> 00:09:34,980
+في قطوف أو عناقين لكن داخل القطوف أو داخل الخيوط
+
+108
+00:09:34,980 --> 00:09:39,860
+والسلاسل كل خلية تتعبر عن نفسها يعني تماما زي أنا
+
+109
+00:09:39,860 --> 00:09:44,980
+مجيب حبة عنب لحالها حبة العنب هي حبة عنب إلها جشرة
+
+110
+00:09:44,980 --> 00:09:54,020
+وإلها لبّة وإلها بذراتوأجيب قطف في مائة حبة عنب لا
+
+111
+00:09:54,020 --> 00:09:58,640
+يعني ان المائة حبة عنب انهم حبة واحدة انما هم مائة
+
+112
+00:09:58,640 --> 00:10:02,980
+حبة كل حبة إلى كيانة مستقل لكن هم مدمجين في
+
+113
+00:10:02,980 --> 00:10:08,440
+cluster ال cluster عنكل فالبكتيريا قد تعيش في
+
+114
+00:10:08,440 --> 00:10:14,800
+عناقيد زي احنا ماشوفنا هنا هيها هذه عناقيد بكتيريا
+
+115
+00:10:14,800 --> 00:10:23,290
+عناقيد بكتيرياو قد تعيش في خليتين و قد تعيش خلية
+
+116
+00:10:23,290 --> 00:10:28,530
+واحدة زي هذا الشكل لكي تكون خلية واحدة والباص اللي
+
+117
+00:10:28,530 --> 00:10:31,550
+هي نفس الشيء يمكن تكون عودة لحالها او عدة عيدان و
+
+118
+00:10:31,550 --> 00:10:35,690
+ال .. و ال .. و ال spiral قد تكون يعني spiral
+
+119
+00:10:35,690 --> 00:10:40,750
+واحدة او عدة spirals طيب الخاصية الرابعة
+
+120
+00:10:44,360 --> 00:10:50,460
+أولاقة البكتيريا بالكائن الذي تعيش فيه يعني
+
+121
+00:10:50,460 --> 00:10:54,800
+البكتيريا طفيلية تعيش في الإنسان في الحيوان في
+
+122
+00:10:54,800 --> 00:11:01,140
+النبات فما هي الأولاقة؟ الأولاقة ان هي تعيش
+
+123
+00:11:01,140 --> 00:11:07,720
+parasitic life أي حياة طفيلية تتطفل على ال host ال
+
+124
+00:11:07,720 --> 00:11:13,980
+host هو العائل المضيفوهذا العيب قد يكون man يعني
+
+125
+00:11:13,980 --> 00:11:20,180
+إنسان أو animal اللي هو حيوان أو plant plant يعني
+
+126
+00:11:20,180 --> 00:11:26,940
+نبات فيه يعني بكتيريا بتعيش في النبات وتتكاتر في
+
+127
+00:11:26,940 --> 00:11:33,400
+النبات كثير من أنواع البكتيريا commensals
+
+128
+00:11:33,400 --> 00:11:39,800
+commensals أي متعايشة وقد تكون مفيدة للإنسان كيف
+
+129
+00:11:39,800 --> 00:11:45,490
+يعني؟يعني مثلًا في بكتيريا بتعيش على الجلد تتعذى
+
+130
+00:11:45,490 --> 00:11:51,290
+من العرق بس من عرقنا ولا تحدث أي أمراض في بكتيريا
+
+131
+00:11:51,290 --> 00:11:55,170
+تعيش في الأمعاء تتغذى على فضلات البراضي ولا تحدث
+
+132
+00:11:55,170 --> 00:11:58,790
+أي أمراض في بكتيريا بتعيش في شعرنا بتعيش على
+
+133
+00:11:58,790 --> 00:12:02,590
+القشور في شعرنا لا تحدث أي أمراض تتغذى على الفضلات
+
+134
+00:12:02,590 --> 00:12:07,830
+الصغيرة فهذه بقولكم منسل لكن ايش الخطر منها الخطر
+
+135
+00:12:07,830 --> 00:12:14,760
+منهاأنه إذا ضعف العائل أو منعت العائل ضعفت لسبب من
+
+136
+00:12:14,760 --> 00:12:19,180
+أسباب فإن هذه الـ commensal تصبح pathogenic تنقلب
+
+137
+00:12:19,180 --> 00:12:23,620
+إلى pathogenic وتغزو داخل الجسم وتفتك به فهي
+
+138
+00:12:23,620 --> 00:12:29,620
+متعايشة بفعل يعني إن الإنسان العائل القوي ومنعته
+
+139
+00:12:29,620 --> 00:12:35,880
+قوية لا تستطيع أن تخترقها فتتغذى على الفضلاتأما
+
+140
+00:12:35,880 --> 00:12:41,780
+إذا اختلت المعادلة وضعفه اللي هو رصيده الإنسان من
+
+141
+00:12:41,780 --> 00:12:48,120
+المناه فإنها تهاجمه وتفتك به وتصبح pathogenic تصبح
+
+142
+00:12:48,120 --> 00:12:52,540
+إيش؟ pathogenic لذا احنا ميزنا العلاقة بين
+
+143
+00:12:52,540 --> 00:12:57,380
+البكتيريا والعيل إنها قد تكون pathogenic مرضية أو
+
+144
+00:12:57,380 --> 00:13:03,050
+تكون commensal متعايشةولا تحدث مرضا إلا في حالات
+
+145
+00:13:03,050 --> 00:13:11,590
+خاصة وهي أن يحدث مرض أو نقص مناعي عند هذا العائل
+
+146
+00:13:11,590 --> 00:13:14,490
+عند هذا العائل طبعا كتير من البكتيريا بتعيش في
+
+147
+00:13:14,490 --> 00:13:18,890
+الأمعاء تولد لنا فيتامينات تساعدنا في قتل
+
+148
+00:13:18,890 --> 00:13:22,750
+البكتيريا المرضية وإذا غابت البكتيريا متعيشة من
+
+149
+00:13:22,750 --> 00:13:26,410
+الأمعاء فإن البكتيريا المرضية تحل وقد تفتك بيه
+
+150
+00:13:26,410 --> 00:13:31,660
+اللي هو القولون والجهاز الهضميالخاصية الخامسة
+
+151
+00:13:31,660 --> 00:13:39,780
+للبكتيريا عموما انها تتكاثر لا جنسيا يعني مافيش
+
+152
+00:13:39,780 --> 00:13:45,480
+بكتيريا ذكر وبكتيريا أنثى كالحيوان والانسان لأ
+
+153
+00:13:45,480 --> 00:13:51,200
+انما تتكاثر بالانقسام الثنائي البسيط simple
+
+154
+00:13:51,200 --> 00:13:55,280
+division اسمه binary fission الانقسام الثنائي
+
+155
+00:13:55,280 --> 00:14:01,640
+البسيطوهو أن الخلية تنقسم إلى خليتين والخليتين إلى
+
+156
+00:14:01,640 --> 00:14:06,400
+أربع والاربع إلى ثماني وهكذا هذا اسمه انقسام ثنائي
+
+157
+00:14:06,400 --> 00:14:13,100
+بسيط وانا الآن احوريكوا الصورة انقسام ثنائي البسيط
+
+158
+00:14:13,100 --> 00:14:19,500
+هذه الصورة انقسام ثنائي البسيط الدقيقة صفر كانت
+
+159
+00:14:19,500 --> 00:14:24,560
+واحدةبعد عشرين دقيقة عشرين minutes صاروا اتنين بعد
+
+160
+00:14:24,560 --> 00:14:30,540
+اربعين دقيقة صاروا اربعين اربع بعد ستين دقيقة
+
+161
+00:14:30,540 --> 00:14:38,740
+صاروا تمانية طيب لو قلت بعد تمانين دقيقة حصروا كم؟
+
+162
+00:14:38,740 --> 00:14:46,620
+ستة عشر بعد مية دقيقة حصروا ستة و تلاتينو هكذا
+
+163
+00:14:46,620 --> 00:14:49,880
+يبقى هذا اسمه انقسام ثنائي بسيط أي أن كل خلية
+
+164
+00:14:49,880 --> 00:14:55,520
+تنقسم إلى اثنتين عندما تن وتكبر و اثنتين نقسم إلى
+
+165
+00:14:55,520 --> 00:15:00,640
+اربع و هكذا انقسام ثنائي بسيط هذه من خصائص
+
+166
+00:15:00,640 --> 00:15:06,320
+البكتيريا العامة خصائص البكتيريا العامة
+
+167
+00:15:12,910 --> 00:15:17,430
+هو انقسام ثنائي بسيط حيث بتقوم الخلية الأم
+
+168
+00:15:17,430 --> 00:15:21,710
+بالانقسام إلى خليتين اسم daughter cells البنات
+
+169
+00:15:21,710 --> 00:15:27,130
+الخلية البنات و الخلية البنات لما ينموا بنقسموا كل
+
+170
+00:15:27,130 --> 00:15:29,990
+واحدة إلى اتنين و مع الوقت بيعملوا colonies
+
+171
+00:15:29,990 --> 00:15:35,950
+bacteria ال colonies هي مستعمرات بكتيريا في بعضها
+
+172
+00:15:35,950 --> 00:15:41,330
+بيعيش في قطوف و بعضها بيعيش في قيوب بيعيش في قيوب
+
+173
+00:15:42,650 --> 00:15:47,610
+أنا هتوقف الآن يعني في هذه المحاضرة المقدمة انا
+
+174
+00:15:47,610 --> 00:15:52,950
+باعتبرها هذه المحاضرة مقدمة تستوعبوها ان شاء الله
+
+175
+00:15:52,950 --> 00:15:56,950
+وسنكمل فيما بعد والسلام عليكم ورحمة الله
+
diff --git a/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/HcDVQpDua9I_raw.srt b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/HcDVQpDua9I_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..6511e10ddb156274477673b91025b4f59868e4f8
--- /dev/null
+++ b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/HcDVQpDua9I_raw.srt
@@ -0,0 +1,944 @@
+1
+00:00:00,000 --> 00:00:03,960
+عوض بالله من الشيطان الرجيم بسم الله الرحمن الرحيم
+
+2
+00:00:03,960 --> 00:00:07,780
+الحمد لله و أكفى و أصلي و أسلم على النبي المصطفى
+
+3
+00:00:07,780 --> 00:00:14,880
+بناتي مستوى الثالث في قسم البصريات الطبية السلام
+
+4
+00:00:14,880 --> 00:00:19,080
+عليكم ورحمة الله وبركاته أعود لكم الآن في المحاضرة
+
+5
+00:00:19,080 --> 00:00:24,400
+الخامسة حول اللي هو bacterial destruction
+
+6
+00:00:24,400 --> 00:00:27,360
+destruction يعني كيف أبيض البكتيريا أتخلص من
+
+7
+00:00:27,360 --> 00:00:31,900
+البكتيرياالبكتيريا تعيش معانا ومعظمها مرضية سبب
+
+8
+00:00:31,900 --> 00:00:37,080
+منها احنا امراض وتفكيث بانسان الجميع فالانسان
+
+9
+00:00:37,080 --> 00:00:40,700
+اتعلم ايضا كيف يقوم البكتيريا بين نوعين نوع اسمه
+
+10
+00:00:40,700 --> 00:00:44,840
+sterilization هي تعقيم ونوع اسمه disinfection
+
+11
+00:00:44,840 --> 00:00:51,020
+تطهير في فرق دقيق بين التعقيم والتطهير لما اقول
+
+12
+00:00:51,020 --> 00:00:56,500
+انا تعقيم يعني اخد بالي ان انا اقصد 100% ازالة
+
+13
+00:00:56,500 --> 00:01:03,990
+للبكتيريايعني ولا واحد من عشرة في المية موجود بس
+
+14
+00:01:03,990 --> 00:01:12,070
+sterilization defined يعرف as destruction يعني
+
+15
+00:01:12,070 --> 00:01:17,010
+إبادة of all forms of بكتيريا كل أطوار البكتيريا
+
+16
+00:01:17,010 --> 00:01:22,030
+أو ال micro organisms حتى الأحياء الدقيقة سواء
+
+17
+00:01:22,030 --> 00:01:28,700
+منها spores المجارتمة أو vegetative المجارتمةby
+
+18
+00:01:28,700 --> 00:01:32,560
+using physical and chemical means باستخدام الوسائل
+
+19
+00:01:32,560 --> 00:01:37,980
+الفيزيائية والكيميائية الوسائل الفيزيائية الشمس
+
+20
+00:01:37,980 --> 00:01:45,660
+مثلا فيزيائية الميه فيزيائية الأشعة
+
+21
+00:01:45,660 --> 00:01:53,400
+فيزيائية الحرارة فيزيائية التلج فيزيائية chemical
+
+22
+00:01:53,400 --> 00:01:58,510
+لأ ال chemical و الكيميائية يعني انا دخلت حامضدخلت
+
+23
+00:01:58,510 --> 00:02:03,330
+قلوي دخلت يعني اي مواد كيميائية عضوية او غير عضوية
+
+24
+00:02:03,330 --> 00:02:09,410
+دخلت الكيميا يبقى الفيزيا بما فيها الكهربا تختلف
+
+25
+00:02:09,410 --> 00:02:13,750
+عن كيميا اللي هي مواد كيميائية يبقى ان انا ابادة
+
+26
+00:02:13,750 --> 00:02:18,630
+لكل انواع او اطوار ال micro organisms ومنها
+
+27
+00:02:18,630 --> 00:02:22,910
+البكتيريا الحياة الداخلية ومنها البكتيريا باستخدام
+
+28
+00:02:22,910 --> 00:02:27,730
+موسائل فيزيائية او كيميائيةالـ disinfection
+
+29
+00:02:27,730 --> 00:02:33,210
+التطهير التطهير لا فيه احتمال يظل لها نسبة عايشة
+
+30
+00:02:33,210 --> 00:02:38,410
+من الأحياء الدقيقة يبقى هي process عملية فيزيائية
+
+31
+00:02:38,410 --> 00:02:44,420
+أو كيميائيةبتعمل تخلص get rid يعني تخلص من
+
+32
+00:02:44,420 --> 00:02:51,640
+البكتيريا البكتيريا المرضية يعني such process may
+
+33
+00:02:51,640 --> 00:02:54,840
+or may not affect bacteria in this form in this
+
+34
+00:02:54,840 --> 00:02:58,120
+form يعني البكتيريا المتجدمة يعني انا لو قلت اني
+
+35
+00:02:58,120 --> 00:03:02,720
+انا طهرت ايديا من البكتيريا يعني حطيت عليها مثلا
+
+36
+00:03:02,720 --> 00:03:07,520
+كحول سميرتو حطيت عليها الجل هذا اللي بيحطوه الآن
+
+37
+00:03:07,520 --> 00:03:12,010
+في صدريهاهذا اسمه تطهير يعني احتمال تسعين في المية
+
+38
+00:03:12,010 --> 00:03:17,210
+من البكتيريا تموت لكن احتمال عشر في المية تظل يعني
+
+39
+00:03:17,210 --> 00:03:25,490
+انا مثلا جليت الطبق بالسابون اه طهرته انا طهرته من
+
+40
+00:03:25,490 --> 00:03:29,930
+الفضلات طهرته ونظفته لكن ماقدرش اقول اني عقمتهيعني
+
+41
+00:03:29,930 --> 00:03:33,850
+انا بتقول انا تعقيم يعني مية مية يعني انا مثلا
+
+42
+00:03:33,850 --> 00:03:39,010
+برشو الأرض بال ال chlorine بقولك عقمنة غلط عقمنة
+
+43
+00:03:39,010 --> 00:03:44,110
+يفروض يقولوا طهرنا طهرنا الصفر طهرنا الأرض طهرنا
+
+44
+00:03:44,110 --> 00:03:48,710
+المطبخ طهرنا أيدينا لكن مابنقولش عقمنة لأن تعقيم
+
+45
+00:03:48,710 --> 00:03:54,410
+مسألة معقدة وعايزة يعني حاجات هقولها الآن هبدأ
+
+46
+00:03:54,410 --> 00:04:02,830
+بالتعقيم مولد التعقيمفى different metals ايش
+
+47
+00:04:02,830 --> 00:04:08,570
+different metals يعني فى عدة وسائل تستخدم فى
+
+48
+00:04:08,570 --> 00:04:14,970
+التحقيق أول واحد ال heat الحرارة الحرارة ربما تكون
+
+49
+00:04:14,970 --> 00:04:22,150
+حرارة جافة أو حرارة مبلولة فيها مياه يعني نبدأ
+
+50
+00:04:22,150 --> 00:04:26,110
+بالحرارة الجافة ايش يعني الحرارة الجافة فى حد اسمه
+
+51
+00:04:26,110 --> 00:04:33,430
+ال heat اللهباللهب يعني انا لو جبت مثلا إبرة إبرة
+
+52
+00:04:33,430 --> 00:04:39,370
+طويلة وحطيتها على النار اه او جبت مجص اه وحطيته
+
+53
+00:04:39,370 --> 00:04:44,390
+على النار اه او جبت اي قالة جراحية عشناك اشي
+
+54
+00:04:44,390 --> 00:04:49,710
+وحطيتها على النار اه على اللهب بقتل كل ال micro
+
+55
+00:04:49,710 --> 00:04:55,310
+organs يعني حركة يعني انا اما احط الشي على النار
+
+56
+00:04:55,310 --> 00:05:03,040
+معناه ان انايعني كون زمان مثلا لو بيعمل مثلا جراحة
+
+57
+00:05:03,040 --> 00:05:07,960
+قبل ما تطلع الأدوات الأجهزة الحديثة كان يحط المشرط
+
+58
+00:05:07,960 --> 00:05:12,880
+على النار اه و بعدين يجرح فيه مية في المية مافيش
+
+59
+00:05:12,880 --> 00:05:17,780
+فيه يعني بكتيريا اللي انخاف لكن طبعا مش هيكون هو
+
+60
+00:05:17,780 --> 00:05:23,820
+يعني فيه من بواقي اللهب يعني بعض الصيناج والسواد
+
+61
+00:05:25,860 --> 00:05:30,080
+الحرارة الجافة التانية incineration الحرق الحرق
+
+62
+00:05:30,080 --> 00:05:37,400
+هذه حقيقة يعني مخلفات الجراحة والمستشفيات و الشاشة
+
+63
+00:05:37,400 --> 00:05:43,220
+اللي في صديق و دم و ملايات الوسخة و بواكي الشاشة
+
+64
+00:05:43,220 --> 00:05:49,320
+الجراحية بيحطوه في برميل و بيحرقوه الحرق لما ال
+
+65
+00:05:49,320 --> 00:05:52,440
+incineration عملت حرق قبل الحرق هي التخلص من
+
+66
+00:05:52,440 --> 00:05:59,900
+البكتيريااللي هو الشاشة والملابس اللي فيها الصديق
+
+67
+00:05:59,900 --> 00:06:04,640
+والدم وهيك احنا نرتاح منها يعني الحرارة جافة اما
+
+68
+00:06:04,640 --> 00:06:14,320
+بلها واما بالحرارة اما النوع التالتليه؟ الحرارة
+
+69
+00:06:14,320 --> 00:06:19,420
+الجافة hot air oven لأ هذا لما طلع هذا فرن تعقيم
+
+70
+00:06:19,420 --> 00:06:26,100
+يعني هذا الفرن بنحط فيه الأقحم الجراحية المجصات
+
+71
+00:06:26,100 --> 00:06:33,260
+والمشارط اللي هو أدوات الجراحة المختلفة مدة ساعة
+
+72
+00:06:33,260 --> 00:06:38,310
+إلى ساعتين في حرارة مية وستين إلى مية وسبعينبنحطه
+
+73
+00:06:38,310 --> 00:06:44,750
+في فرن زي هذا زي هيك شوف زي التلاجة الصغيرة وبتسكر
+
+74
+00:06:44,750 --> 00:06:48,890
+ويله مكياز حراري على الكهربا يعني هو electrical
+
+75
+00:06:48,890 --> 00:06:58,900
+ديهاز كهربائيهوت ايه ال oven يعني فرن تعقيم وبعدين
+
+76
+00:06:58,900 --> 00:07:03,580
+هذا بتفكر عليه مدة ساعتين ومن قط فيه كل الأدوات
+
+77
+00:07:03,580 --> 00:07:10,020
+الجراحية الدوارب الجزايز السيلنجات الإجازأي حاجة
+
+78
+00:07:10,020 --> 00:07:15,600
+حديد من أدوات جراحية اه مدة ساعة او ساعتين مئو
+
+79
+00:07:15,600 --> 00:07:20,320
+سبعين درجة بطلعها fully sterilized ايش sterilized
+
+80
+00:07:20,320 --> 00:07:23,720
+يعني و اقل مائة بالمائة يعني بتعمل عملية جراحية
+
+81
+00:07:23,720 --> 00:07:27,880
+وانت مطمن ان مافيش بكتيريا راح تدخل في هذا الجرح
+
+82
+00:07:27,880 --> 00:07:29,580
+او في هذه العملية
+
+83
+00:07:32,270 --> 00:07:36,270
+الحقيقة انه لو هيك hot air open اول ما طلع قبل
+
+84
+00:07:36,270 --> 00:07:43,470
+حوالي يمكن 80 سنة او 70 سنة كان فعال جدا لكن موضوع
+
+85
+00:07:43,470 --> 00:07:48,030
+الساعة الى ساعتين هذه يعني خلت الوضع بعد هيك صعب
+
+86
+00:07:48,030 --> 00:07:51,770
+لان العملات الجراحية زادت في المستشفيات و لو كل
+
+87
+00:07:51,770 --> 00:07:56,170
+انا طاقم جراحي طاقم جراحي ولبس اللي هو الجراحين و
+
+88
+00:07:56,170 --> 00:08:00,610
+الشاشةبدي انا اخليه ساعتين فى الفرن يعنى كام عملية
+
+89
+00:08:00,610 --> 00:08:03,030
+بدي اشتغل فى اليوم كام عملية بدي اشتغل فى اليوم
+
+90
+00:08:03,030 --> 00:08:05,930
+علمى انه كل طاقة اللى بنعمل فى عملية بده ينعاد
+
+91
+00:08:05,930 --> 00:08:10,250
+اللى هو وضعه فى الفرن من اول و جديد بعد ايقافه
+
+92
+00:08:10,250 --> 00:08:18,390
+وهذا يعني مش عملي لكن احنا بنقول تاريخيا ان الفرن
+
+93
+00:08:18,390 --> 00:08:25,500
+الحرارى هو يستخدم فى التعقيمليه المستشفيات قال
+
+94
+00:08:25,500 --> 00:08:29,860
+المستشفيات هو يعني و باقي نتاجي كويسة لكن انه خمس
+
+95
+00:08:29,860 --> 00:08:34,760
+ساعة او ساعتين يعني جعل بعد هيك ال auto class اللي
+
+96
+00:08:34,760 --> 00:08:38,040
+جاي هذا أحسن منه أسرع منه و أسرع منه خلال ربع
+
+97
+00:08:38,040 --> 00:08:42,320
+الساعة ده بيشتغل لكن بيظلوا في الحرارة الجافة هو
+
+98
+00:08:42,320 --> 00:08:46,460
+النوع التالت يبقى الحرارة الجافة red heat اللهب
+
+99
+00:08:46,460 --> 00:08:54,950
+flameأو حرق للتخلص من المواد القادرة او ال hot air
+
+100
+00:08:54,950 --> 00:09:00,070
+open في المستشفيات و الآن صار قديم يعني قل
+
+101
+00:09:00,070 --> 00:09:03,670
+استعماله كثير إلا في الدول المتخلفة الحرارة
+
+102
+00:09:03,670 --> 00:09:07,650
+التانية اسمها moist air الحرارة المبللة يعني ما
+
+103
+00:09:07,650 --> 00:09:11,890
+تدخل فيها ميه وهذه فكرة القدر الكاتم ال auto
+
+104
+00:09:11,890 --> 00:09:19,500
+-cleave اللي هو التعقيم في المستشفياتوهذا يعتمد
+
+105
+00:09:19,500 --> 00:09:23,180
+على pressure
+
+106
+00:09:23,180 --> 00:09:33,420
+بزيادة الضغط فوق الضغط الجوي لماء مغلي يعني انا
+
+107
+00:09:33,420 --> 00:09:40,200
+فكرة طنجرة الكهربا القدر الكاتب اللي بتصفر هذه شوف
+
+108
+00:09:40,200 --> 00:09:45,330
+يعني انت بتحط فيها اللحم و قدر من الماءوبتكتمها
+
+109
+00:09:45,330 --> 00:09:49,710
+وبعدين لما تبدأ تصفر تبدأ توطي النار مثلا بعد ربع
+
+110
+00:09:49,710 --> 00:09:56,270
+ساعة تاخد لحم يعني ناضج جدا لأنه استخدمت الضغط
+
+111
+00:09:56,270 --> 00:10:03,230
+الحرارة تحت الضغط ضغط البخار يبقى هذه المي المغلية
+
+112
+00:10:03,230 --> 00:10:08,590
+لا يسمح البخار ان يطلع وبالتالي بزيد الضغط داخل ال
+
+113
+00:10:08,590 --> 00:10:15,510
+Autoclave هذامع حرارة تصل الى 121 درجة مئاوية بمدة
+
+114
+00:10:15,510 --> 00:10:18,830
+ربع ساعة فقط خمس عشر دقيقة بتعطيك full
+
+115
+00:10:18,830 --> 00:10:23,830
+sterilization الضغط بيكون حوالي خمس عشر رطل
+
+116
+00:10:23,830 --> 00:10:29,670
+انجريزي على كل انش مربع من مساحة الفورم جوا هذا مش
+
+117
+00:10:29,670 --> 00:10:38,710
+مهم الكتير المهم يعني اللي هو الحرارة تحت الضغط
+
+118
+00:10:40,530 --> 00:10:45,370
+الداخل اللى هو الفرن هذا بيقول ان هذا ال autoclave
+
+119
+00:10:45,370 --> 00:10:51,390
+يستخدم لتعقيم surgical instruments كلمة surgical
+
+120
+00:10:51,390 --> 00:10:54,670
+instruments يعني اللى هو أدوات الجراحة قبقم
+
+121
+00:10:54,670 --> 00:10:58,630
+الجراحة تعقيم كل عملية جراحية إلى طجنب يعني مثلا
+
+122
+00:10:58,630 --> 00:11:02,270
+عمليات العيون تختلف عن عمليات المعدةتختلف عن عملية
+
+123
+00:11:02,270 --> 00:11:06,270
+القلون تختلف عن عملية الغضروف تختلف عن عملية المخ
+
+124
+00:11:06,270 --> 00:11:10,710
+تختلف عن عملية الأدن تختلف عن عملية النسا والولادة
+
+125
+00:11:10,710 --> 00:11:18,870
+و هكذا بما فيها الفوط والشاشة أدوات الجراحة وملابس
+
+126
+00:11:18,870 --> 00:11:24,970
+الجراحين كلها تنحطواطباق المدارس البكتيرية كلها
+
+127
+00:11:24,970 --> 00:11:29,390
+بتنحط تاكلوا و بتطلع وهذه الصورة ربما مشكل ال
+
+128
+00:11:29,390 --> 00:11:34,770
+autoplay يلو باب هيو بتسكر اه و بتعمل كويس و بعدين
+
+129
+00:11:34,770 --> 00:11:41,740
+بتحط الحرارةعلى مؤشر معين وعلى الكهربا وبعد خمساشر
+
+130
+00:11:41,740 --> 00:11:48,220
+دقيقة من الحرارة
+
+131
+00:11:48,220 --> 00:11:54,260
+والضبط بناخد تعقيم كامل للأدوات اللي احنا حاطناها
+
+132
+00:11:54,260 --> 00:11:59,840
+داخل هذا ال اوتوكليز يبقى هذه الحرارة المبالغة لل
+
+133
+00:11:59,840 --> 00:12:03,260
+اوتوكليز فيه ميه يعني لازم تحط فيه ميه في الفاشنجر
+
+134
+00:12:03,260 --> 00:12:08,890
+الميه ال اوتوكليز لازم يكون فيهقدر من الميه فيه
+
+135
+00:12:08,890 --> 00:12:13,270
+عشان هي اللي بدها بعد مية درجة تبدأ تجلي والبخار
+
+136
+00:12:13,270 --> 00:12:18,250
+ان كتم البخار ان كتم داخل هذا اللي هو الوتوكليف
+
+137
+00:12:18,250 --> 00:12:24,250
+جهاز التعقيد في شي اسمه pasteurization Pasteur هو
+
+138
+00:12:24,250 --> 00:12:33,530
+عالم فرنسي أول من فكر في البسترة البسترةليه الملك
+
+139
+00:12:33,530 --> 00:12:40,330
+الحليب المبسطر جاب الحليب المبسطر حطه في نص ساعة
+
+140
+00:12:40,330 --> 00:12:46,290
+اتنين وستين درجه ميئاوية في جهاز نص ساعة اتنين
+
+141
+00:12:46,290 --> 00:12:50,490
+وستين ونص درجه ميئاوية وبعدين بعد هيك راح حط رابد
+
+142
+00:12:50,490 --> 00:12:56,830
+كولينغ رابد كولينغ حطه في فريزر وجرب
+
+143
+00:12:56,830 --> 00:13:02,550
+هذا الكلام مع النبيذ و مع الحليب وجد انه100% تشفي
+
+144
+00:13:02,550 --> 00:13:07,210
+بكتيريا ومن هنا طلع الحليب ال مبسطر ال milk هذا
+
+145
+00:13:07,210 --> 00:13:12,450
+تشفي اي نوع من البكتيريا لا تفوئيد ولا سبت كوكاي
+
+146
+00:13:12,450 --> 00:13:16,010
+ولا TB ولا بروسيلا اللى بتعمل القمة الملطية هذه
+
+147
+00:13:16,010 --> 00:13:19,890
+القمة الملطية وهذه بتعمل السل سبت كوكاي بتعمل
+
+148
+00:13:19,890 --> 00:13:24,770
+الصديد والتفوئيد من البكتيريا كلها صارت الحليب
+
+149
+00:13:24,770 --> 00:13:31,400
+خالص منها بس هي اتقدم للبشريةصحيح انه يعني خدمة
+
+150
+00:13:31,400 --> 00:13:36,660
+كتير انه هو سخن الحليب لنص ساعة اتنين وستين ونص
+
+151
+00:13:36,660 --> 00:13:40,540
+وبعدين حطه في ال freezer بعد هيك ليه جي البكتيريا
+
+152
+00:13:40,540 --> 00:13:44,200
+كلها ماتت والان احنا بنشرب حليب من بستر في الججايز
+
+153
+00:13:44,200 --> 00:13:48,910
+او في الكياسبدون أي بكتيريا و بدون ما نخاف لإن
+
+154
+00:13:48,910 --> 00:13:53,890
+احنا ناخد حليب البقر و نشربه مرة واحدة ممكن ان
+
+155
+00:13:53,890 --> 00:13:57,350
+يكون فيه أمراض كثيرة لكن مجرد الحليب المبسطر حتى
+
+156
+00:13:57,350 --> 00:14:01,410
+لا يغلى ماتغلهوش خد الحليب المبسطر اللي في الجزايز
+
+157
+00:14:01,410 --> 00:14:06,110
+او في كيات النيلون و اشربه بارد مافيش فيه اي نوع
+
+158
+00:14:06,110 --> 00:14:11,650
+من اللي هو البكتيريا الضارة الوسيلة التالتة من
+
+159
+00:14:11,650 --> 00:14:13,710
+الحرارة المبللة
+
+160
+00:14:15,850 --> 00:14:21,030
+boiling water الميه المغلية يعني لو انا جب اي مجص
+
+161
+00:14:21,030 --> 00:14:28,050
+جب اي سيرنجة حاجة اه وحطيتها في ميه مغلية مدة عشر
+
+162
+00:14:28,050 --> 00:14:33,230
+دقايق ممكن انا اقتل البكتيريا اللي فيها بنسبة فوق
+
+163
+00:14:33,230 --> 00:14:37,830
+التسعين في الميةإلا بعض أنواع البكتيريا لاتموت في
+
+164
+00:14:37,830 --> 00:14:41,630
+المغلية اللي هو المي المغلية دا equilibrium تتناعي
+
+165
+00:14:41,630 --> 00:14:46,190
+البكتيريه مسبب بان المرض التفنس أو الكزاز بتموتش
+
+166
+00:14:46,190 --> 00:14:51,370
+كذلك بعض البكتيريا المجارسةلو حطيت للميه المجلية
+
+167
+00:14:51,370 --> 00:14:58,990
+كربونات Sodium كربونات الفلافل هذه 2% ممكن تزيد في
+
+168
+00:14:58,990 --> 00:15:02,970
+كفاءة الميه المجلية وتخطل بكتير اكتر حقيقة احنا
+
+169
+00:15:02,970 --> 00:15:07,710
+كنا قبل عشرات سنين بنستخدم في الجراحة الميه
+
+170
+00:15:07,710 --> 00:15:14,280
+المجلية لتعقيم المجصات والملاجئوحتى السيرينجات
+
+171
+00:15:14,280 --> 00:15:19,160
+لجزاز وبعض الحاجات للصحاحات لكن بعد ما طلع ال auto
+
+172
+00:15:19,160 --> 00:15:22,560
+-cleave ده اشترنا الميه المغلية لكن التاريخ بتظل
+
+173
+00:15:22,560 --> 00:15:26,580
+هذه الميه المغلية هي احد الأدوات لما ماتيسرش غيرها
+
+174
+00:15:26,580 --> 00:15:32,000
+بنغلي اللي هو اللي هو الاشياء في الميه المغلية
+
+175
+00:15:32,000 --> 00:15:40,300
+احسن من مستخدمها بدون تعقيم طيب الآن خلصنا الحرارة
+
+176
+00:15:41,000 --> 00:15:44,820
+خلصنا الحرارة الحرارة نوعين حرارة جافة و حرارة
+
+177
+00:15:44,820 --> 00:15:50,720
+مبللة الان في بيه radiation الإشعاع والإشعاع احنا
+
+178
+00:15:50,720 --> 00:15:58,000
+عنا نوعين في إشعاع طبيعي الإشعة الشمس وفي إشعاع
+
+179
+00:15:58,000 --> 00:16:02,000
+radiation radiation يعني ionizing radiation من
+
+180
+00:16:02,000 --> 00:16:05,060
+المواد المشعة المواد المشعة اللى بتسمع عنها
+
+181
+00:16:05,060 --> 00:16:10,050
+الإشعاع الذرىالأشعة الشمس بتحتوي على نوعين من
+
+182
+00:16:10,050 --> 00:16:18,010
+الأشعة في نوع اسمه ultraviolet ultra U ultraviolet
+
+183
+00:16:18,010 --> 00:16:28,430
+و infrared اش ال ultraviolet فوق البنفسدية U UV
+
+184
+00:16:28,430 --> 00:16:31,550
+ultraviolet
+
+185
+00:16:31,550 --> 00:16:37,380
+فوق البنفسدية و infrared تحت الحمرانفي واحدة اللى
+
+186
+00:16:37,380 --> 00:16:41,540
+هو infrared طويل طويل اللى هو الموجي طول الموجي
+
+187
+00:16:41,540 --> 00:16:45,360
+طويل وهدى ultraviolet قصيرة والاشعة فيها تانية
+
+188
+00:16:45,360 --> 00:16:50,080
+عشان هيك اشعة الشمس تستخدم كثيرا في التعقيم
+
+189
+00:16:50,080 --> 00:16:53,640
+بالاشعتين
+
+190
+00:16:53,640 --> 00:16:59,480
+هدولة ليه اللى هو ال operating rooms ورا في
+
+191
+00:16:59,480 --> 00:17:05,390
+الجراحةو دور الحضارة nurseries دور الحضارة بتاعة
+
+192
+00:17:05,390 --> 00:17:12,130
+الرضع و اللي هو ورط الأمراض المعدية منكم ال
+
+193
+00:17:12,130 --> 00:17:19,450
+disease زي مثلا ال cell و زي ال cholera و زي اللي
+
+194
+00:17:19,450 --> 00:17:23,810
+هو الأشياء هذه الأمراض المعدية و زي المعامل
+
+195
+00:17:23,810 --> 00:17:30,840
+البكتيريةاللي فيها تجارب بكتيرية وزي ال nurses ال
+
+196
+00:17:30,840 --> 00:17:34,540
+restaurant المطابق المطابق الكبرى لازم يعرضوها
+
+197
+00:17:34,540 --> 00:17:40,140
+للشعع هاري الشمس وحتى فيه لُمَض فيها artificial
+
+198
+00:17:40,140 --> 00:17:46,920
+atrovirus لُمَض اللي هو أشعة بنفسجية فوق البنفسجية
+
+199
+00:17:46,920 --> 00:17:51,220
+من لُمَض خاصة قديما قالوا البيت اللي تدخله الشمس
+
+200
+00:17:51,220 --> 00:17:56,560
+لا يدخله الطبيبجا دايما كل ما الشمس تدخل غرف تدخل
+
+201
+00:17:56,560 --> 00:18:05,720
+أماكن تدخل معامل تدخل مستشفيات تعمل على التعقيد
+
+202
+00:18:05,720 --> 00:18:13,920
+خاصة شمس الصباح و شمس آخر النهار أما الإشعاع
+
+203
+00:18:13,920 --> 00:18:23,220
+الصناعي من مواد مشعة زي ال radio مثلابقول ان هذه
+
+204
+00:18:23,220 --> 00:18:33,420
+إلها يعني أثر فتاك على الميكروبات اه وكتير يعني
+
+205
+00:18:33,420 --> 00:18:41,480
+بيستخدموها اه في صناعات الدوائية زي pharmaceutical
+
+206
+00:18:41,480 --> 00:18:47,160
+في صناعة الدوائية وصناعة الأدوات الدراحيةوخاصة
+
+207
+00:18:47,160 --> 00:18:50,640
+disposable syringe surgical instruments زي مثلا
+
+208
+00:18:50,640 --> 00:18:54,500
+السيرينجات لمرة واحدة باسم البلاستيك هذه وكل
+
+209
+00:18:54,500 --> 00:18:59,160
+الجراحات الآن لها قطكم لمرة واحدة disposable يعني
+
+210
+00:18:59,160 --> 00:19:04,080
+استخدمه ورميه مشرب تستخدمه مجص تستخدمه ورميه اي
+
+211
+00:19:04,080 --> 00:19:09,560
+حاجة تستخدمه ورميها سيرينجة اي حاجة وهذه طبعا في
+
+212
+00:19:09,560 --> 00:19:13,920
+شركات كبرى اسمها pharmaceuticalsتعمل إمدادات للشيء
+
+213
+00:19:13,920 --> 00:19:19,460
+هذا تستخدم رشعات ذرية نوية وهذا شغل دول متقدمة مش
+
+214
+00:19:19,460 --> 00:19:27,060
+شغل يعني ناس زينة خلصنا الأشعة للتعقيم انه اجتالت
+
+215
+00:19:27,060 --> 00:19:31,260
+للتعقيم اسمه filtration التشيح وهذه طريقة قديمة
+
+216
+00:19:31,260 --> 00:19:39,480
+يعني لما يكون مثلا في سوائل مضاد حيوي يعني
+
+217
+00:19:40,520 --> 00:19:45,340
+لو سخّرناها أو عرضناها لأشعة تخرب فاحنا بنجيبها في
+
+218
+00:19:45,340 --> 00:19:50,100
+filter ال filter يبقى عبارة عن زي شبك ريونه صغير
+
+219
+00:19:50,100 --> 00:19:55,460
+جدا محط فيه سائل المضاد الحيوي فهو برشح إن الحاجات
+
+220
+00:19:55,460 --> 00:19:59,720
+الضارة وبنزل تحت الحاجات اللي كويسة أو انها كانت
+
+221
+00:19:59,720 --> 00:20:02,900
+ال antibiotic solutions وبالتالي احنا ماعرضناهش
+
+222
+00:20:02,900 --> 00:20:09,280
+الحرارة حتى يتلقىوهي مثال للفلتر هى مثال للفلتر هى
+
+223
+00:20:09,280 --> 00:20:14,460
+before وهى after before كان في شوائض الفلتر هذا هى
+
+224
+00:20:14,460 --> 00:20:19,800
+العيون دى جامسكها وطلع إنه اشي نقي مافيش فيه هذه
+
+225
+00:20:19,800 --> 00:20:21,140
+الشوائض
+
+226
+00:20:23,710 --> 00:20:29,050
+هو لما يكون بنخاف المادة أو السائل يسيبه damage من
+
+227
+00:20:29,050 --> 00:20:33,190
+الحرارة damage يعني التلف من الحرارة فبنحطه في
+
+228
+00:20:33,190 --> 00:20:38,890
+filter شبكت عيون ال جيجا وبنصفيه وبالتالي احنا
+
+229
+00:20:38,890 --> 00:20:44,270
+بنطلعه نقي من هذه الشوائط دون التلف بالحرارة دون
+
+230
+00:20:44,270 --> 00:20:49,680
+التلفبالحرارة انا اقرأ انه نستكفي بما وصلنا اليه
+
+231
+00:20:49,680 --> 00:20:54,840
+في محاضرة الخامسة ونقف عند التطهير المرة القادمة
+
+232
+00:20:54,840 --> 00:21:01,600
+يعني بأمر الله وانا شايف الأمور هتكون أحسنوهي أنا
+
+233
+00:21:01,600 --> 00:21:05,540
+شايف طالباتي يعني بدوا يستوعبوا بس تقراوا أولا
+
+234
+00:21:05,540 --> 00:21:09,720
+فأول وإن شاء الله ألتقيكم المحاضرة اللي جاية في
+
+235
+00:21:09,720 --> 00:21:16,840
+اللي هو التطهير this infection شكرا لكم والسلام
+
+236
+00:21:16,840 --> 00:21:17,340
+عليكم
+
diff --git a/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/JY40xlROEF0.srt b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/JY40xlROEF0.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f80ea0145ce68805a76323897366177429f93cf2
--- /dev/null
+++ b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/JY40xlROEF0.srt
@@ -0,0 +1,1371 @@
+1
+00:00:00,230 --> 00:00:06,350
+الرحمن الرحيم الحمد لله وكفى واصلي واسلم على النبي 
+
+2
+00:00:06,350 --> 00:00:12,170
+المصطفى بناتي قسم البصريات المستوى الثالث السلام 
+
+3
+00:00:12,170 --> 00:00:16,490
+عليكم ورحمة الله وبركاته إن شاء الله تعالى
+
+4
+00:00:16,490 --> 00:00:23,070
+يعني إحنا في انطلاقة نحو الامتحان النهائي في هذا 
+
+5
+00:00:23,070 --> 00:00:27,250
+الْمَصَادِر وبالتالي إحنا بنحاول نحضر المحاضرات لكوا
+
+6
+00:00:27,250 --> 00:00:31,350
+يعني بدرجة شوية عشان أنتو تقرؤوها وتكونوا مستعدين
+
+7
+00:00:31,350 --> 00:00:36,690
+بدي استعداد وبدي أنا ثقة بالله ثقة بنفسي الآن
+
+8
+00:00:36,690 --> 00:00:39,430
+الموضوع بتاعنا مهم جدا هو bacterial
+
+9
+00:00:39,430 --> 00:00:44,770
+endophthalmitis بنعطي كلمة endo داخلي exo خارجي
+
+10
+00:00:44,770 --> 00:00:48,850
+لما أقول endophthalmitis يعني إيه يكون فيه بكتيريا
+
+11
+00:00:48,850 --> 00:00:55,900
+داخل العين يعني مش باقي برا القرنية في كيس ملتحمة في 
+
+12
+00:00:55,900 --> 00:00:59,980
+الجفون لأ تكون البكتيريا وين داخلة العين يعني
+
+13
+00:00:59,980 --> 00:01:06,140
+اخترقت القرنية وخشت جوا العين فبنسميها اندو اندو
+
+14
+00:01:06,140 --> 00:01:10,080
+يعني داخل في طالما يعني داخل العين وهذا طبعا مش 
+
+15
+00:01:10,080 --> 00:01:17,460
+أشياء خطيرة جدا اللي ممكن تملاعبها هي البكتيريا
+
+16
+00:01:17,460 --> 00:01:22,900
+الاندوفتالميتس دخلت البكتيريا انفكشت عدى البكتيريا 
+
+17
+00:01:22,900 --> 00:01:28,000
+internal contents of the globe دخلت داخل البكتيريا
+
+18
+00:01:28,000 --> 00:01:44,220
+الاندوفتالميتس الاندوفتالميتس الاندوفتالميتس 
+
+19
+00:01:45,110 --> 00:01:53,730
+الاندوفتالميتس التَّجَسِّيمَة بتاعتها يعني بيدّي طرق أول
+
+20
+00:01:53,730 --> 00:02:01,670
+تجسيمة ممكن حسب ال microorganism اللي دخل العدوى
+
+21
+00:02:01,670 --> 00:02:09,540
+هل هي بكتيرية؟ هل هي فطريات؟ هل هي فيروسات؟ هل هي 
+
+22
+00:02:09,540 --> 00:02:15,240
+بروتوزوهات؟ أي شيء دخل داخل العين واتكثر فيها عمل
+
+23
+00:02:15,240 --> 00:02:19,680
+infecting of endophthalmitis حسب نوع ال organism
+
+24
+00:02:19,680 --> 00:02:23,760
+اللي دخل أكثر شيء بدخل حقيقة البكتيريا البكتيريا 
+
+25
+00:02:23,760 --> 00:02:28,900
+هي المتسببة بمعظم ال endophthalmitis لكن لو دخل
+
+26
+00:02:28,900 --> 00:02:32,540
+fungus أو بروتوزوهات أو حتى فيروس ممكن يعمل 
+
+27
+00:02:32,540 --> 00:02:41,420
+endophthalmitis في تقسيمة ثانية في تقسيمة كلينيكية يعني
+
+28
+00:02:41,420 --> 00:02:49,580
+حسب الأعراض بقول post traumatic or post operative
+
+29
+00:02:49,580 --> 00:02:56,200
+يعني هل هي إذا بعد حدث شيء دخل في العين من حادث 
+
+30
+00:02:56,200 --> 00:03:04,970
+سيارة من حادث مشاجرة ضربة أي شيء حجر سكين شوكة دخلت في 
+
+31
+00:03:04,970 --> 00:03:11,470
+العين ولا عملية جراحية يعني منظمة في العين وأي شيء 
+
+32
+00:03:11,470 --> 00:03:16,030
+طبعا واضح أن ال post operative بيكون فيها تعقيم و
+
+33
+00:03:16,030 --> 00:03:20,190
+الجراح بيكون معقم وأدواته معقمة لكن ال post
+
+34
+00:03:20,190 --> 00:03:24,990
+operative اللي ضرب سكينة وشوكة وحجر في عينه و
+
+35
+00:03:24,990 --> 00:03:29,490
+دخل الحجر هذا البكتيريا أو السكينة طبعا هذه ملوثة
+
+36
+00:03:29,490 --> 00:03:35,140
+خطيرة يعني طيب الشيء الثالث root of infection طريقة
+
+37
+00:03:35,140 --> 00:03:40,020
+العدوى هل أن هذه البكتيريا اللي خشت مثلا اجت من 
+
+38
+00:03:40,020 --> 00:03:46,840
+برا يعني من خارج العين ولا من داخل الجسم نفسه من
+
+39
+00:03:46,840 --> 00:03:55,620
+داخل الجسم يعني مثلا واحد يعني بيكار دخل في عين
+
+40
+00:03:55,620 --> 00:04:02,680
+والبيكار هذا ملوث أو سن سرنجة دخل في عينه ملوث هذا
+
+41
+00:04:02,680 --> 00:04:08,260
+إكس جونز هذا إيش إكسّه من برا إيش يعني طيب واحد
+
+42
+00:04:08,260 --> 00:04:14,840
+معاه دمل في الرئة أو دمل في الكبد وهذا الدمل في
+
+43
+00:04:14,840 --> 00:04:19,840
+صديد وبكتيريا حملها الدم ودخلها على العين هذا اندو
+
+44
+00:04:19,840 --> 00:04:25,620
+من داخل الجسم اندو يعني اندو من جوا طيب الشيء
+
+45
+00:04:25,620 --> 00:04:30,560
+الرابع في التَّكْسِيبَة بتاعة الحسب specific infectious
+
+46
+00:04:30,560 --> 00:04:36,820
+agent specific يعني فيه حاجات معينة يعني زي مثلا
+
+47
+00:04:36,820 --> 00:04:41,540
+ال syphilis ال syphilis آه يعني هذا اللي بيكون فيه
+
+48
+00:04:41,540 --> 00:04:45,240
+syphilis ممكن إنه ينتج للعين ويعمل endophthalmitis
+
+49
+00:04:45,240 --> 00:04:52,560
+حاجات نادرة هنا يعني فعلا في شيء اسمه pan of 
+
+50
+00:04:52,560 --> 00:05:01,380
+panophthalmitis إيش الفرق بين pan وبين endo ال endo يعني
+
+51
+00:05:01,380 --> 00:05:06,040
+بكتيريا مثلا دخلت العين واتكاترت عين الصليب لكن
+
+52
+00:05:06,040 --> 00:05:13,700
+pan كل أجزاء العين أصابها ال infection sclera و
+
+53
+00:05:13,700 --> 00:05:18,760
+القرنية وما بينهما يعني هذه القرنية هيك وهي 
+
+54
+00:05:18,760 --> 00:05:26,050
+sclera هيك وما بينهما يعني هذا صعب من هنا من هنا و
+
+55
+00:05:26,050 --> 00:05:29,810
+من هنا ومن هنا ومن هنا ومن هنا ومن هنا و
+
+56
+00:05:29,810 --> 00:05:30,690
+من هنا ومن هنا ومن هنا ومن هنا ومن هنا و
+
+57
+00:05:30,690 --> 00:05:35,270
+من هنا ومن هنا ومن هنا ومن هنا ومن هنا و
+
+58
+00:05:35,270 --> 00:05:37,330
+من هنا ومن هنا ومن هنا ومن هنا ومن هنا و
+
+59
+00:05:37,330 --> 00:05:37,430
+من هنا ومن هنا ومن هنا ومن هنا ومن هنا و
+
+60
+00:05:37,430 --> 00:05:38,110
+من هنا ومن هنا ومن هنا ومن هنا ومن هنا و
+
+61
+00:05:38,110 --> 00:05:45,370
+من هنا ومن هنا ومن هنا ومن هنا ومن هنا و
+
+62
+00:05:45,370 --> 00:05:45,490
+من هنا ومن هنا ومن هنا ومن هنا ومن هنا و
+
+63
+00:05:45,490 --> 00:05:47,030
+من هنا ومن هنا ومن هنا ومن هنا ومن هنا و
+
+64
+00:05:47,030 --> 00:05:47,290
+من هنا ومن هنا ومن هنا ومن هنا ومن هنا و
+
+65
+00:05:47,290 --> 00:05:48,230
+من هنا ومن هنا ومن هنا ومن هنا ومن هنا و
+
+66
+00:05:48,230 --> 00:05:51,670
+من هنا ومن هنا ومن هنا
+
+67
+00:05:54,680 --> 00:05:58,880
+يعني إحنا لو أدركنا الموضوع في ال endophthalmitis
+
+68
+00:05:58,880 --> 00:06:03,300
+ممكن نشيل القرنية ونفضي العين ونخلص clear والعضلات بركب عليها عين صناعية لكن لو صار pan of
+
+69
+00:06:03,300 --> 00:06:07,520
+panophthalmitis بدنا نخلع العين من وين من العصب من ورا
+
+70
+00:06:07,520 --> 00:06:13,680
+من هنا يعني
+
+71
+00:06:13,680 --> 00:06:17,620
+بدنا 
+
+72
+00:06:20,760 --> 00:06:30,340
+نعمل إزالة لكل العين مش إزالة محتويات العين آه آه
+
+73
+00:06:30,340 --> 00:06:36,040
+evisceration لما أنا بطلب المعلجة evisceration 
+
+74
+00:06:36,040 --> 00:06:40,180
+evisceration يعني أن أنا طلعت محتويات العين بس 
+
+75
+00:06:40,180 --> 00:06:46,160
+وطلعت ال sclera ركبة تركب فيها اللي هو عين صناعية
+
+76
+00:06:47,180 --> 00:06:55,840
+لكن enucleation enucleation enucleation 
+
+77
+00:06:55,840 --> 00:06:59,840
+enucleation enucleation enucleation enucleation
+
+78
+00:06:59,840 --> 00:07:00,420
+enucleation enucleation enucleation enucleation
+
+79
+00:07:00,420 --> 00:07:02,300
+enucleation enucleation enucleation enucleation
+
+80
+00:07:02,300 --> 00:07:06,260
+enucleation enucleation enucleation enucleation
+
+81
+00:07:06,260 --> 00:07:11,860
+enucleation enucleation
+
+82
+00:07:11,860 --> 00:07:19,150
+enucleation enucleation enucleation ال infection بياخد 
+
+83
+00:07:19,150 --> 00:07:24,130
+من عند ال scleral cornea قدام كله بيصيبه ال
+
+84
+00:07:24,130 --> 00:07:28,530
+infection آه ويعني إحنا بس بنتكلم عن ال
+
+85
+00:07:28,530 --> 00:07:31,050
+endophthalmitis الآن مش عارف ما هي endophthalmitis 
+
+86
+00:07:31,050 --> 00:07:34,290
+يعني كلامنا عن ال endo هاي عين فيها 
+
+87
+00:07:34,290 --> 00:07:38,510
+endophthalmitis كلها صديق وهي عين فيها
+
+88
+00:07:38,510 --> 00:07:42,210
+endophthalmitis كلها صديق طيب أنواع ال
+
+89
+00:07:42,210 --> 00:07:45,650
+endophthalmitis كنا post-operative بالغالب بعد 
+
+90
+00:07:45,650 --> 00:07:51,090
+عملية جراحية وعملت جراحية اللي بتشيل العدسة 
+
+91
+00:07:51,090 --> 00:07:54,210
+الخربانة اللي داخل العين معظمها cataract يعني 
+
+92
+00:07:54,210 --> 00:07:59,090
+بتشيل العدسة الخربانة اللي فيها cataract وجالين
+
+93
+00:07:59,090 --> 00:08:03,470
+منها glaucoma جالين منها بتفتح فتحة لمية العين تمشي 
+
+94
+00:08:03,470 --> 00:08:09,470
+وما يركبش ضغط العين بس 90% من اللي هو ال post
+
+95
+00:08:09,470 --> 00:08:17,810
+operative cataract طبعا مهما عمل له علاج للهندو
+
+96
+00:08:17,810 --> 00:08:23,310
+ophthalmitis فبيكون النتيجة poor vision إن ما كانش إنه
+
+97
+00:08:23,310 --> 00:08:28,690
+blindness يعني إحنا من أول ما يبدأ العين إن ما
+
+98
+00:08:28,690 --> 00:08:33,530
+يشوف شوي غبش ويتألم ابن الحجوب مضادة حيوية جوا
+
+99
+00:08:33,530 --> 00:08:38,630
+العين وبرا العين وفي المحلول وممكن إنه نشيله
+
+100
+00:08:38,630 --> 00:08:43,390
+البكتيريا ونحط له saline وكلام لكنه بيقول يعني ال
+
+101
+00:08:43,390 --> 00:08:48,370
+visual prognosis النتيجة النهائية غالبا poor
+
+102
+00:08:48,370 --> 00:08:55,230
+vision يعني نظر ضعيف إن نجحت إن ما كانش فيه عمى طيب
+
+103
+00:08:55,230 --> 00:08:59,250
+هنتكلم ال post operative endophthalmitis اللي بتيجي
+
+104
+00:08:59,250 --> 00:09:03,710
+بعد الكتر إحنا معظم العملية الجراحية اللي بيصير 
+
+105
+00:09:03,710 --> 00:09:10,390
+فيها ال endophthalmitis هي cataract بقول لي إنه في هذه 
+
+106
+00:09:10,390 --> 00:09:14,490
+العملية إنه في video الوصي يعني عمى الفيديو الوصي
+
+107
+00:09:14,490 --> 00:09:21,490
+يعني فقد البصر عمى في ثلث اللي هو اللي اللي اللي
+
+108
+00:09:21,490 --> 00:09:26,410
+الثلث المصابين بال endophthalmitis بيصيروا عمى يعني يعني
+
+109
+00:09:26,410 --> 00:09:34,720
+مثلا لو ستين واحد صابهم الاندوفتالميتس ممكن يكونوا 
+
+110
+00:09:34,720 --> 00:09:42,380
+عشرين منهم عميان بعد هيك وأربعين لحقهم بقول
+
+111
+00:09:42,380 --> 00:09:46,540
+لي إنه الخطر بتاع الاندوفتالميتس بعد ال cataract
+
+112
+00:09:46,540 --> 00:09:52,970
+surgery موجود حتى في الدول المتقدمة آه well
+
+113
+00:09:52,970 --> 00:10:00,210
+developed countries بنسبة من 0.05% إلى 3% من خمسة
+
+114
+00:10:00,210 --> 00:10:05,090
+على مية في المية إلى تلاتة في المية بيصيبهم إيش من
+
+115
+00:10:05,090 --> 00:10:10,190
+اللي عملوا لهم كترك بيصيبهم endophthalmitis
+
+116
+00:10:10,190 --> 00:10:14,770
+بيقول لي من ومان إن ده كده بتيجي غالبا بتكون هي في 
+
+117
+00:10:14,770 --> 00:10:20,390
+الكنجرة الطيبة أول ما تلاقي فتحة مشرعة تدخل عشان
+
+118
+00:10:20,390 --> 00:10:24,620
+هيك قبل عملية جراحية إحنا إيش بنعمل بنحاول نعقم 
+
+119
+00:10:24,620 --> 00:10:30,440
+ونطهر الملتحمة كويس كويس كويس حتى ما يخشش منها
+
+120
+00:10:30,440 --> 00:10:35,180
+شيء يعني لما تكون البكتيريا برا على سطح القرنية
+
+121
+00:10:35,180 --> 00:10:39,540
+وسطح الملتحمة شيء ولما تلاقي فتحة وتخش جوا العين
+
+122
+00:10:39,540 --> 00:10:44,970
+شيء آخر بيقول إنه في مجموعة اسمها endophthalmitis 
+
+123
+00:10:44,970 --> 00:10:49,130
+retractomy study دراسة اللي هو ال endophthalmitis
+
+124
+00:10:49,130 --> 00:10:55,410
+اللي بيعملوا لهم إزالة للجسم الزرجالي بيقول إنه 70%
+
+125
+00:10:55,410 --> 00:11:03,050
+من المزرعة بتكون positive آه positive إن عندي 
+
+126
+00:11:03,050 --> 00:11:07,630
+بكتيريا البكتيريا محبوسة جوا العين وغالبا هذه
+
+127
+00:11:07,630 --> 00:11:12,560
+بتكون coagulase negative يعني تفرش coagulase نظام 
+
+128
+00:11:12,560 --> 00:11:16,500
+أجرام بسطف كوكاي اسمه Staphylococcus epidermidis 
+
+129
+00:11:16,500 --> 00:11:20,640
+Staphylococcus epidermidis إحنا خدناها قبل هيك إن 
+
+130
+00:11:20,640 --> 00:11:26,900
+أنت بتعيش على الجلد بتعيش على الجلد لكن
+
+131
+00:11:26,900 --> 00:11:33,360
+لو لقت فتحة في النمبس ودخلتها دي وقال إيه أنت تصبح
+
+132
+00:11:33,360 --> 00:11:38,690
+خطيرة جدا يعني فرق ما تعيش على الجلد متعايشة مثالمة 
+
+133
+00:11:38,690 --> 00:11:44,010
+هو بين ما تدخل داخلها وتعمل الأعمال بتاعتها لذلك
+
+134
+00:11:44,010 --> 00:11:51,550
+هذه ال Staphylococcus epidermidis هي المتهمة طيب النقطة
+
+135
+00:11:51,550 --> 00:11:55,690
+التالية من endophthalmitis تقول لي pseudophakic
+
+136
+00:11:55,690 --> 00:12:01,130
+endophthalmitis إحنا عارفين phakic يعني
+
+137
+00:12:01,130 --> 00:12:05,110
+العدسة الأصلية موجودة لما تكون العدسة الأصلية
+
+138
+00:12:05,110 --> 00:12:15,110
+موجودة a هنا والعين هذه fake eyes طيب لو انضربت
+
+139
+00:12:15,110 --> 00:12:19,930
+هذه العدسة وسقطت مثلا هنا بيصير هذه a fake eyes
+
+141
+00:12:19,930 --> 00:12:26,510
+بحطها A A FAKE EYES طيب لو شلنا العدسة و ركبنا
+
+142
+00:12:26,510 --> 00:12:32,510
+عدسة صناعية اللي لها زنبرة كأنه مركّبنا عدسة صناعية
+
+143
+00:12:32,510 --> 00:12:38,510
+هذي بيصير سودو فاكهة سودو فاكهة عدسة صناعية مركبة
+
+144
+00:12:38,510 --> 00:12:41,690
+بدل الأصلية أما الأفاكهة مافيش عدسة بالمرة
+
+145
+00:12:41,690 --> 00:12:47,390
+والفاكهة هو الطبيعي بيقول
+
+146
+00:12:47,390 --> 00:12:52,890
+لي انه لجوا أن كتير من العدسات اللي بيصير لها
+
+147
+00:12:52,890 --> 00:12:56,970
+implantation بيزرعوها يعني جوا العين بدل عدسة
+
+148
+00:12:56,970 --> 00:13:02,720
+الخربانة اللي فيها كترة بتكون ملوثة تكون ثمانية أما
+
+149
+00:13:02,720 --> 00:13:08,480
+ملوثة مش معقمة كويس من مصنعها أو هي expired يعني
+
+150
+00:13:08,480 --> 00:13:13,280
+لما يضعوا العدسة في البكيت بتاعها وبجانبها
+
+151
+00:13:13,280 --> 00:13:17,820
+بيكتبوا أن خلال ست شهور لازم تكون اتركبة في ناس
+
+152
+00:13:17,820 --> 00:13:20,820
+بيسأله مش عندهم كمية كبيرة بيقول لك هو بيغير التاريخ
+
+153
+00:13:20,820 --> 00:13:25,400
+بعد سنتين بيركبها بتكون ملوثة يعني التعقيم
+
+154
+00:13:25,400 --> 00:13:33,230
+بيضمنهاش بعد ست شهور مثلابتعمل بكتيريا
+
+155
+00:13:33,230 --> 00:13:37,090
+الاندوفطالميتس تدخل البكتيريا تزرعها تعمل
+
+156
+00:13:37,090 --> 00:13:42,350
+اندوفطالميتس وتعمل نيكروتايزين كيراتايتس يعني إذا
+
+157
+00:13:42,350 --> 00:13:51,530
+بقى ليه القرانية مع موجود البكتيريا داخل العين
+
+158
+00:13:51,530 --> 00:13:58,240
+نيكروتايزين كيراتايتس و الـ stroma وكله بيحصل فيه
+
+159
+00:13:58,240 --> 00:14:02,400
+نكروزيس يعني إذابة نكروت ال tissue للـ stroma
+
+160
+00:14:02,400 --> 00:14:05,940
+until الـ stroma وبصير الـ stroma وكله بيحصل في ال
+
+161
+00:14:05,940 --> 00:14:10,800
+diet هاي مثال للـ pseudophytic bacterial
+
+162
+00:14:10,800 --> 00:14:14,340
+endocrinitis شوفوا يعني كيف الوضع هنا وكيف الوضع
+
+163
+00:14:14,340 --> 00:14:20,760
+هنا وضع كئيب جدا من الصديق طيب النقطة الثالثة من ال
+
+164
+00:14:20,760 --> 00:14:26,260
+endocrinitis بعد اللي هو past filtration الـ boss
+
+165
+00:14:26,260 --> 00:14:29,560
+filtration يعني أن عملنا احنا مصفة في حالة
+
+166
+00:14:29,560 --> 00:14:34,680
+جلوكوما بنعمل filter اسمه يعني جراحة مثلا إيه آه
+
+167
+00:14:34,680 --> 00:14:37,080
+في الجلوكوما بنجي احنا بنفتح الـ petra bicarb مش food
+
+168
+00:14:37,080 --> 00:14:42,620
+org فتحة هيك قناع عشان يسهل خروج الأكل والـ humor
+
+169
+00:14:42,620 --> 00:14:46,140
+من الـ bistruit chamber إلى الـ interior chamber إلى
+
+170
+00:14:46,140 --> 00:14:46,520
+الـ angle
+
+171
+00:14:50,660 --> 00:14:57,800
+الشركة قامت بتفتح بيئة جديدة للبكتيريا لتخش من
+
+172
+00:14:57,800 --> 00:15:03,140
+الملتحمة البكتيريا
+
+173
+00:15:03,140 --> 00:15:06,560
+الاندروفنالمايتس باء لجلوكوما سيرجري اسمه filter
+
+174
+00:15:09,660 --> 00:15:13,120
+زادت في الفترة الأخيرة لأن احنا عملنا Trapeziotomy
+
+175
+00:15:13,120 --> 00:15:17,240
+Trapeziotomy هو هذا الشباك اللي بنعمله قطع في
+
+176
+00:15:17,240 --> 00:15:20,740
+Trapeziotomy مشوار عند الـ upper limbus عارفين
+
+177
+00:15:20,740 --> 00:15:24,260
+upper limbus اللي هو هنا يعني هذا الـ limbus كله
+
+178
+00:15:24,260 --> 00:15:27,860
+هنا الـ upper limbus بنعمل نافذة يعني هذه النافذة
+
+179
+00:15:27,860 --> 00:15:33,810
+بتربط بين الـ Antelope Chamber وبين الملتحمة طب
+
+180
+00:15:33,810 --> 00:15:38,270
+الملتحمة كتير فيها ميكروبيات وبكتيريا بتخش يعني في
+
+181
+00:15:38,270 --> 00:15:41,090
+العين دي بيكون في anatomic barrier احنا ال
+
+182
+00:15:41,090 --> 00:15:45,730
+anatomic barrier هذا الحاجز التشريحي احنا وقفناه
+
+183
+00:15:45,730 --> 00:15:49,170
+أو قطعناه وبالتالي صارت السهل البكتيريا تخش من
+
+184
+00:15:49,170 --> 00:15:53,170
+الملتحمة إلى الـ antelope chamber وتعمل endothermia
+
+185
+00:15:53,170 --> 00:16:02,270
+يبقى صار في portal social portal يعني مدخل افتراضي
+
+186
+00:16:02,270 --> 00:16:06,630
+آه في الجرح هذا اللي عملناه بتربيكلر مش ورق
+
+187
+00:16:06,630 --> 00:16:09,750
+البكتيريا اللي بتخش في الموضوع هذا اسمها
+
+188
+00:16:09,750 --> 00:16:13,450
+hemophilus influenza أكتر شيء hemophilus influenza
+
+189
+00:16:13,450 --> 00:16:18,490
+بكتيريا و streptococcus species أنواع الستربتوكوكية
+
+190
+00:16:18,490 --> 00:16:25,370
+اللي بتكون في الملتحمة ومتعايشة بتخش جوا إلى داخل
+
+191
+00:16:25,370 --> 00:16:27,550
+الـ interior chamber
+
+192
+00:16:29,620 --> 00:16:34,520
+هي عملية filter شايفين هي قطعنا هنا احنا قطع في
+
+193
+00:16:34,520 --> 00:16:39,400
+الترابيكو المشوار وفتحنا فتحة اللي السائري يجي من
+
+194
+00:16:39,400 --> 00:16:42,780
+ورا بيصير الـ chamber والأكل في الـ chamber ويخش
+
+195
+00:16:42,780 --> 00:16:47,920
+في الملتحمة والملتحمة بتصرفه مع الدم فبقول أن
+
+196
+00:16:47,920 --> 00:16:53,000
+وجدوا كتير من العينين اللي صار فيها endothelamitis
+
+197
+00:16:53,000 --> 00:16:56,580
+بعد عملية القطع هذا في الترابيكو المشوار
+
+198
+00:16:56,580 --> 00:17:04,170
+endothelamitisشافوا كثير من حالات صديري التهاب
+
+199
+00:17:04,170 --> 00:17:08,430
+صديري وزي هذا التهاب الصديري بالظبط زي post
+
+200
+00:17:08,430 --> 00:17:13,150
+cataract endothalamic يعني النتيجة واحدة صدير داخل
+
+201
+00:17:13,150 --> 00:17:17,730
+العين وبكتيريا كانت في مزرعة بس داخل العين يعني in
+
+202
+00:17:17,730 --> 00:17:18,490
+vivo
+
+203
+00:17:21,870 --> 00:17:26,930
+بس بقول لي الفرق بين cataract ومن الجلوكوما أن ال
+
+204
+00:17:26,930 --> 00:17:30,890
+cataract في خلال أسبوع بتكون ساعة اندفترامات
+
+205
+00:17:30,890 --> 00:17:34,050
+إسكندرانية لكن الاندفترامات اللي post
+
+206
+00:17:34,050 --> 00:17:37,490
+-trabeculectomy اللي بعد الجلوكوما قطع الجلوكوما
+
+207
+00:17:37,490 --> 00:17:41,770
+trabeculectomy ممكن تصير بعد شهور أو بعد سنين بعد
+
+208
+00:17:41,770 --> 00:17:47,860
+شهور أو بعد سنين وهذا الخطر فيه يعني المريض ممكن
+
+209
+00:17:47,860 --> 00:17:51,060
+يعمل له عملية ويمشي الحال وضغط العين بتاعه يكون
+
+210
+00:17:51,060 --> 00:17:55,800
+كويس من الجلوكوما وبعد ست شهور أو سنة اللاجئ عينه
+
+211
+00:17:55,800 --> 00:17:58,220
+انتج صديد وهذه ستكون المفاجأة لكن بالنسبة لي
+
+212
+00:17:58,220 --> 00:18:01,620
+الكاتراكت احنا بنعمل له عملية ونخلي أسبوع تحت
+
+213
+00:18:01,620 --> 00:18:06,880
+المراقبة أن مضى أسبوع بيكون مر بسلام والبكتيريا ما
+
+214
+00:18:06,880 --> 00:18:11,960
+دخلت في عينه يعني الـ boss cataract أكتر أمانًا من ال
+
+215
+00:18:11,960 --> 00:18:14,740
+boss trabeculectomy بتاع الجلوكوما
+
+216
+00:18:16,880 --> 00:18:22,200
+طيب قصة traumatic يعني ولاد صغير بيلعبوا في بيكار
+
+217
+00:18:22,200 --> 00:18:27,000
+ولاد صغير بيلعبوا في حجار بيلعبوا في سكين أكل
+
+218
+00:18:27,000 --> 00:18:31,520
+بيلعبوا في الشوكت أثناء الطعام دخل اللي قال الحد
+
+219
+00:18:31,520 --> 00:18:34,880
+يده في العين حادث اسمه trauma طب الـ trauma إيش
+
+220
+00:18:34,880 --> 00:18:38,360
+بعدها بيصير post because of somitis بعد ال
+
+221
+00:18:38,360 --> 00:18:42,180
+accidental injury بعد الحادث هذا اللي صار في العين
+
+222
+00:18:44,260 --> 00:18:49,180
+خاصة لما يحصل حرق العين من ناحية القرنية غالبًا
+
+223
+00:18:49,180 --> 00:18:55,220
+Penetrating trauma يعني ضربة نافذة من العين هو
+
+224
+00:18:55,220 --> 00:19:00,940
+risk خطر منه أن يعمل endocrinitis طبعًا لكن العديد
+
+225
+00:19:00,940 --> 00:19:07,700
+أن بالدراسة مثلًا على 82 واحد لجوا بس من خارجة
+
+226
+00:19:07,700 --> 00:19:12,410
+تانيهم اثنين بس من صابوا في دراسة ثانية يعني
+
+227
+00:19:12,410 --> 00:19:20,210
+reproductive study يعني دراسة مسبقة من الـ 122 لجوا
+
+228
+00:19:20,210 --> 00:19:26,730
+بس 4 عيني قالوا طب بقول يعني أن يعني هال .. هال
+
+229
+00:19:26,730 --> 00:19:31,530
+بيكر أو هذا اللي دخل بس يعني 4 من 122 أو 2 من 82
+
+230
+00:19:31,530 --> 00:19:38,470
+قالوا آه ليش قالوا في أسباب السبب الأول أن أول ما
+
+231
+00:19:38,470 --> 00:19:43,210
+تنصب العين بيجوا جاي على المستشفى عشان يسكروه
+
+232
+00:19:43,210 --> 00:19:50,050
+micro surgical repair of the wound repair يعني
+
+233
+00:19:50,050 --> 00:19:57,310
+خياطة خياطة repair خياطة للجرح مش موجود أن انضرب
+
+234
+00:19:57,310 --> 00:20:01,170
+في عينه نسيه مياه عينه وأن يخلوه يقعد في الدار
+
+235
+00:20:01,170 --> 00:20:07,230
+أفندي لأنه ألم شديد وبشوفش فكل
+
+236
+00:20:07,230 --> 00:20:11,300
+ما لاحظوا على المستشفى وخياطوله الجرح كل ما جلبت
+
+237
+00:20:11,300 --> 00:20:14,020
+تمال دخول البكتيريا أن تعمل انتصار متس داخلها
+
+238
+00:20:14,020 --> 00:20:18,980
+الثاني effective antibiotic يعني هذا مش بس هم
+
+239
+00:20:18,980 --> 00:20:26,120
+بخيطونه بعتوا antibiotic في عينه مضاد حيوي قطرة
+
+240
+00:20:26,120 --> 00:20:30,640
+مضاد حيوي حجم ومضاد حيوي في المحلول اللي بركبه في
+
+241
+00:20:30,640 --> 00:20:36,420
+الوريد فهذا الـ antibiotic بيكون effective يعني إيش
+
+242
+00:20:36,420 --> 00:20:41,930
+يعني قوي ومؤثر هذا بنقض العين بعد الحادث أو اختراق
+
+243
+00:20:41,930 --> 00:20:46,970
+العين بأي آلة حادة أن تعمل اندروس هالمانتزا
+
+244
+00:20:46,970 --> 00:20:51,770
+البكتيريا اللي في الحالات بتاعة الـ accidental أو
+
+245
+00:20:51,770 --> 00:20:56,310
+post traumatic infections اللي شائعة ريوها على غير
+
+246
+00:20:56,310 --> 00:21:02,790
+شكل اسمه باسيلاس سيرياس باسيلاس سيرياس الـ most
+
+247
+00:21:02,790 --> 00:21:07,460
+common isolate يعني اللي تم اكتشافها وعزلها في خمسة
+
+248
+00:21:07,460 --> 00:21:11,680
+إلى ست حلق من الـ boss traumatic endophthalmitis
+
+249
+00:21:11,680 --> 00:21:19,520
+boss traumatic endophthalmitis هاي
+
+250
+00:21:19,520 --> 00:21:26,840
+جرح في العين نافذ آه وبده خياطة بده رز عشان نمنع
+
+251
+00:21:26,840 --> 00:21:32,520
+البكتيريا أن تعيش فيه متغرض الشلال يعني ساعات تصير
+
+252
+00:21:32,520 --> 00:21:35,240
+مشكلة تصير ذوي الهدف endophthalmitis
+
+253
+00:21:39,930 --> 00:21:45,410
+طيب بقول أن يعني البكتيريا هذه المثلة الـ serious
+
+254
+00:21:45,410 --> 00:21:50,670
+هي gram positive spore forming يعني أنت تقدر في
+
+255
+00:21:50,670 --> 00:21:59,590
+حالة عدم وجود الطعام وتكون يعني فيها جفاف أو حامض
+
+256
+00:21:59,590 --> 00:22:03,230
+أو قلوي تعمل spore و spore أخذناه في خلية
+
+257
+00:22:03,230 --> 00:22:08,390
+البكتيريا في البداية يبقى هي موجودة في المية موجودة
+
+258
+00:22:08,390 --> 00:22:14,530
+في التربة موجودة في أماكن كثيرة بتلوث الأسطح حقيقة
+
+259
+00:22:14,530 --> 00:22:19,690
+آه وموجودة common soil bacterium يعني هي في التربة
+
+260
+00:22:19,690 --> 00:22:28,170
+والرمل موجودة لكثير وإلها toxins آه بلا جوه
+
+261
+00:22:28,170 --> 00:22:34,190
+الـ toxins هاري السموم في الـ wound في العين أو في
+
+262
+00:22:34,190 --> 00:22:40,010
+الجرح العالي له يقول باسيلا سيرياس آه لها toxins
+
+263
+00:22:40,010 --> 00:22:46,090
+طيب النوع الخامس من الـ endothalamic metastatic
+
+264
+00:22:46,090 --> 00:22:51,330
+metastatic يعني أن من داخل الجسم انتقل من عضو إلى
+
+265
+00:22:51,330 --> 00:22:55,520
+عضو عن طريق الدم مثلًا يعني مثلًا في دمل في الكبس
+
+266
+00:22:55,520 --> 00:23:00,200
+دمل في الرئة دمل في المخ والدمل هذا فيه
+
+267
+00:23:00,200 --> 00:23:05,240
+بكتيريا تمكن فيك تتحرر من الدمل وتدخل في الدم و
+
+268
+00:23:05,240 --> 00:23:08,560
+تعمل بكتيريميا بكتيريميا يعني بكتيريا in blood
+
+269
+00:23:08,560 --> 00:23:14,940
+بكتيريا in blood طبعًا هتمشي وين ما هتصل هتعمل إيش
+
+270
+00:23:14,940 --> 00:23:19,660
+infection طب لو وصلت هي العين عن طريق الـ central
+
+271
+00:23:19,660 --> 00:23:28,450
+retinal artery فتمت سيرياص disease أو الـ داخل العين
+
+272
+00:23:28,450 --> 00:23:35,110
+يعني الـ metastatic مع أنه minority of septic
+
+273
+00:23:35,110 --> 00:23:40,310
+patients بيعملوه يعني جديد جدا إلا أنه وارد أن
+
+274
+00:23:40,310 --> 00:23:47,340
+تصير يعني وارد أن لو واحد عنده دمل داخل جسمه وطلع
+
+275
+00:23:47,340 --> 00:23:51,320
+البكتيريا من دمها لعمل بكتيريميا في الدم أن اتصل
+
+276
+00:23:51,320 --> 00:23:55,520
+تعمل intraocular infection تعمل عجة داخل العين
+
+277
+00:23:55,520 --> 00:24:02,880
+الـ metastatic endostalmitis في بحث أن من 101 حالة
+
+278
+00:24:02,880 --> 00:24:07,280
+عندهم يعني مثلًا lung abscess أو liver abscess
+
+279
+00:24:07,280 --> 00:24:12,760
+رجعوا حالة واحدة عملت اندوستالميتس ممكن أن راحت
+
+280
+00:24:12,760 --> 00:24:18,660
+على أجزاء أخرى من جسم يعني عملته مثلًا انفكشن في 
+
+281
+00:24:18,660 --> 00:24:24,560
+منتجة ثانية انفكشن في الدماغ في المخ في الكبد في
+
+282
+00:24:24,560 --> 00:24:30,480
+المعدة في القولون في البنكرياس ممكن لكن بالنسبة
+
+283
+00:24:30,480 --> 00:24:34,400
+للعين لأن الـ  تري دي جديد ثاني السمك ثاني الـ تري 
+
+284
+00:24:34,400 --> 00:24:38,800
+يعني جليد بتخش البكتيريا وبتعمل endophthalmitis
+
+285
+00:24:38,800 --> 00:24:44,390
+هذا بيجي عن طريق سمك سمك إنبولاي Septic Hemorrhage
+
+286
+00:24:44,390 --> 00:24:50,330
+يعني بتكون اللي طلعت من الدمل اللي بتحمل البكتيريا 
+
+287
+00:24:50,330 --> 00:24:55,550
+دُلطات أو سدّادات صغيرة بتخش من الـ central retinal
+
+288
+00:24:55,550 --> 00:25:02,790
+artery اسمها Rot Spots زي أصغر من أصغر حبة رمل
+
+289
+00:25:02,790 --> 00:25:06,350
+ودخلت من الـ central retinal artery عشان تعمل
+
+290
+00:25:06,350 --> 00:25:09,850
+endophthalmic لأن الـ central retinal artery يعني 
+
+291
+00:25:09,850 --> 00:25:15,610
+الـ diameter بتاعه أقل من نصف مليمتر يعني ما بدخلش جلُقات
+
+292
+00:25:15,610 --> 00:25:22,310
+كبيرة لتدخل منه بيقول لي إيش هي الـ metastatic لخمس 
+
+293
+00:25:22,310 --> 00:25:26,570
+البكتيريا اللي بتكون حاملها كتير بكتيريا ممكن حسب
+
+294
+00:25:26,570 --> 00:25:30,530
+الدم اللي في داخل الجسم Staphylococcus aureus
+
+295
+00:25:30,530 --> 00:25:34,670
+Staphylococcin pneumonia يعني معظم Staphylococcus
+
+296
+00:25:34,670 --> 00:25:38,470
+و Staphylococcus فيه خمسين إلى خمسة وسبعين في
+
+297
+00:25:38,470 --> 00:25:42,720
+المية من البكتيريا كلها جرام نيجاتيف وبزيتيف لكن جرام
+
+298
+00:25:42,720 --> 00:25:46,540
+نيجاتيف أجالي منها إكليبسيلة سيو دو موناس اديونوزا
+
+299
+00:25:46,540 --> 00:25:50,640
+كلمنا عنها في القوانين الألصار جمال هيك وإكليبسيلة
+
+300
+00:25:50,640 --> 00:25:56,360
+كل هذا اي كولاي إشريشيا كولاي أنيساريا مينجايتسأه
+
+301
+00:25:56,360 --> 00:26:00,000
+بتشكل 900 ميلي جرام نيجاتيف يبقى هي في جرام 
+
+302
+00:26:00,000 --> 00:26:03,880
+positive بكتيريا قد تكون ساكنة جوا الجسم أو جرام
+
+303
+00:26:03,880 --> 00:26:08,260
+negative اللي بتحرر من الدمل و بيطلع بيعمل 
+
+304
+00:26:08,260 --> 00:26:14,120
+امبولايسيبتك و بيروح على العين سواء جرام positive
+
+305
+00:26:14,120 --> 00:26:20,560
+أو جرام negative واللي في آخر 15 سنة لجبلة 
+
+306
+00:26:20,560 --> 00:26:24,020
+الفسيلة زادت أدوية نفسي يعني من داخل دمام الجسم
+
+307
+00:26:24,560 --> 00:26:29,950
+وانطلقت للعين آه هي زادت لأسباب غير معلومة بقول من
+
+308
+00:26:29,950 --> 00:26:32,830
+العوامل المساعدة أنه يكون عنده سكري diabetes
+
+309
+00:26:32,830 --> 00:26:36,770
+mellitus ومنعته جليل هذا المريض أو عنده liver
+
+310
+00:26:36,770 --> 00:26:41,050
+abscess أو liver abscess يعني دم الكبد وممكن lung
+
+311
+00:26:41,050 --> 00:26:45,290
+abscess كتير برضه آه هو risk factor يعني عوامل خطر
+
+312
+00:26:45,290 --> 00:26:47,930
+أنه هذا اللي ما عنده diabetes mellitus أو liver
+
+313
+00:26:47,930 --> 00:26:52,050
+abscess أنه تنتقل البكتيريا بشكل metastatic
+
+314
+00:26:52,050 --> 00:26:55,550
+bacteria endophthalmatis للعين طيب إيش بقول لي
+
+315
+00:26:55,550 --> 00:27:00,420
+أشياء بتساعد يعني أو بتحدد أنه هذه البكتيريا تستطيع 
+
+316
+00:27:00,420 --> 00:27:05,140
+أنها تعمل في العين يعني endothalmitis يعني بكتيريا 
+
+317
+00:27:05,140 --> 00:27:08,160
+تمليها بكتيريا ولا لا الـ virulence إذا كان والله
+
+318
+00:27:08,160 --> 00:27:13,320
+البكتيريا virulent يعني شرسة وقوية بتعمل بعدين
+
+319
+00:27:13,320 --> 00:27:18,620
+الوقت الذي يمر ما بين infection و الـ examination
+
+320
+00:27:18,620 --> 00:27:23,910
+والله في واحد أول ما عينه تتقلم وبيروح بيجريهو 
+
+321
+00:27:23,910 --> 00:27:27,030
+بيكرر في النظر عنده وبيروح يجري وفي واحد بعد شهر
+
+322
+00:27:27,030 --> 00:27:30,690
+لما يسأل لما تخرب عينه لما يروح يعمل examination
+
+323
+00:27:30,690 --> 00:27:34,830
+في المستشفى أو عند طبيب مقتصر effectiveness of 
+
+324
+00:27:34,830 --> 00:27:38,400
+treatment يعني مش كل واحد أعطى علاج أعطى علاج والله
+
+325
+00:27:38,400 --> 00:27:43,220
+اندفنالمايتس علاجه يجب أن يكون علاج قوي جدا ومن
+
+326
+00:27:43,220 --> 00:27:46,800
+البداية أما العلاج الطب طبعه يعني بس مجرد خطرات و
+
+327
+00:27:46,800 --> 00:27:53,620
+كلام antibiotic ما نفعش قد نحتاج أن نعمل removal of
+
+328
+00:27:53,620 --> 00:27:57,230
+the vitreous في الـ vitrectomy إنّه نشيل
+
+329
+00:27:57,230 --> 00:28:01,410
+الـ vitreous كله ونحط انتيبويتك ومحل بداله حتى 
+
+330
+00:28:01,410 --> 00:28:05,270
+نجدِ على البكتيريا اللي داخل العين فمش أي علاج ولا 
+
+331
+00:28:05,270 --> 00:28:10,730
+وقت العلاج يكون طويل لازم نلحقه بسرعة آخر قشعة 
+
+332
+00:28:10,730 --> 00:28:14,710
+location of septic embolism يعني هي وين اللي جاية
+
+333
+00:28:14,710 --> 00:28:21,530
+هل هي جاية في الـ vitreous ولا هي جاية في الرتينة ولا
+
+334
+00:28:21,530 --> 00:28:28,430
+جاية في blood vessel بتاع الرتينة ولا جاية يعني داخل 
+
+335
+00:28:28,430 --> 00:28:33,010
+الكرُوج حسب كل ما كانت داخل العين أكثر كل ما عندك
+
+336
+00:28:33,010 --> 00:28:38,710
+عملة ban of thalmitis صديقي طيب 
+
+337
+00:28:38,710 --> 00:28:44,310
+هذه الصورة ban of thalmitis ban يعني هذا خلاص كل
+
+338
+00:28:44,310 --> 00:28:48,730
+عين بدها جرف ما فيها كلام هذه يعني العين هذه لازم
+
+339
+00:28:48,730 --> 00:28:54,560
+تتدحط وتطلع برة بما فيها سكليرة والعضلات كله كله من 
+
+340
+00:28:54,560 --> 00:28:58,480
+عند العصب من ورا أنا بشكركم على فرصة الاستماع لهذه 
+
+341
+00:28:58,480 --> 00:29:03,420
+المحاضرة الشيقة وأسأل الله عز وجل أنه يكونوا 
+
+342
+00:29:03,420 --> 00:29:08,000
+استفدتوا من هذه المحاضرة وإحنا نتواصل معاكم 
+
+343
+00:29:08,000 --> 00:29:13,500
+باستمرار إن شاء الله نتواصل معاكم باستمرار إلى أنّه
+
+344
+00:29:13,500 --> 00:29:14,500
+نصل لآخر محاضرة 
diff --git a/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/JY40xlROEF0_postprocess.srt b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/JY40xlROEF0_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..02b0408ba8f111a142d97362a2247279f3022196
--- /dev/null
+++ b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/JY40xlROEF0_postprocess.srt
@@ -0,0 +1,1376 @@
+1
+00:00:00,230 --> 00:00:06,350
+الرحمن الرحيم الحمد لله وكفا واصلي واسلم على النبي
+
+2
+00:00:06,350 --> 00:00:12,170
+المصطفى بناتي قسم البصريات المستوى الثالث السلام
+
+3
+00:00:12,170 --> 00:00:16,490
+عليكم ورحمة الله وبركاته ان شاء الله بني تعالى
+
+4
+00:00:16,490 --> 00:00:23,070
+يعني احنا في انطلاقة نحو الامتحان النهائيفي هذا
+
+5
+00:00:23,070 --> 00:00:27,250
+المصادر وبالتالي احنا بنحاول نحضر المحاضرات لكوا
+
+6
+00:00:27,250 --> 00:00:31,350
+يعني بدر شوية عشان انتوا تقرؤوها و تكونوا مستعدين
+
+7
+00:00:31,350 --> 00:00:36,690
+بدي استعداد و بدي انا ثقة بالله ثقة بنفس الان
+
+8
+00:00:36,690 --> 00:00:39,430
+الموضوع بتاعنا مهم جدا هو bacterial
+
+9
+00:00:39,430 --> 00:00:44,770
+endophthalmitis بنعطي كلمة endo داخلي exo خارجي
+
+10
+00:00:44,770 --> 00:00:48,850
+لما اقول endophthalmitis يعني ايه يكون فيه بكتيريا
+
+11
+00:00:48,850 --> 00:00:55,900
+داخل العين يعني مشبقى برا القرنية فى كيس ملتحمة فى
+
+12
+00:00:55,900 --> 00:00:59,980
+الجفون لأ تكون البكتيريا وين داخلة العين يعني
+
+13
+00:00:59,980 --> 00:01:06,140
+اخترقت القرنية وخشت جوا العين فبنسميها اندو اندو
+
+14
+00:01:06,140 --> 00:01:10,080
+يعني داخل في طالمات يعني داخل العين وهذا طبعا مش
+
+15
+00:01:10,080 --> 00:01:17,460
+أشياء خطيرة جدا اللى ممكن تملعبهاهي البكتيريا
+
+16
+00:01:17,460 --> 00:01:22,900
+الاندوفتالميتس دخل البكتيريا انفكشت عدو البكتيريا
+
+17
+00:01:22,900 --> 00:01:28,000
+internal contents of the globe دخلت داخل البكتيريا
+
+18
+00:01:28,000 --> 00:01:44,220
+الاندوفتالميتس الاندوفتالميتس الاندوفتالميتس
+
+19
+00:01:45,110 --> 00:01:53,730
+الاندفعالميتس التجسيمة بتاعتها يعني بيدّه طرق أول
+
+20
+00:01:53,730 --> 00:02:01,670
+تجسيمة ممكن حسب ال microorganism اللي دخل العدوى
+
+21
+00:02:01,670 --> 00:02:09,540
+هل هي بكتيريةهل هي فطريات؟ هل هي فيروسات؟ هل هي
+
+22
+00:02:09,540 --> 00:02:15,240
+بروتوزوهات؟ اي شيء دخل داخل العين واتكتر فيها عمل
+
+23
+00:02:15,240 --> 00:02:19,680
+infecting of endothelmites حسب نوع ال organism
+
+24
+00:02:19,680 --> 00:02:23,760
+اللي دخل اكتر اشي بدخل حقيقة البكتيريا البكتيريا
+
+25
+00:02:23,760 --> 00:02:28,900
+هي المتسببة بمعظم ال endothelmites لكن لو دخل
+
+26
+00:02:28,900 --> 00:02:32,540
+fungus او بروتوزوهات او حتى فيروس ممكن يعمل
+
+27
+00:02:32,540 --> 00:02:41,420
+endothelmitesفي تقسيمة تانية في تقسيمة كليكية يعني
+
+28
+00:02:41,420 --> 00:02:49,580
+حسب الأعراض بقول post traumatic or post operative
+
+29
+00:02:49,580 --> 00:02:56,200
+يعني هل هي إذا بعد حدث شيء دخل في العين من حادث
+
+30
+00:02:56,200 --> 00:03:04,970
+سيارة من حادث مشاجرة ضربةأشي حجر سكين شوكة دخلت في
+
+31
+00:03:04,970 --> 00:03:11,470
+العين و لا عملية جراحية يعني منتظمة في العين و اشي
+
+32
+00:03:11,470 --> 00:03:16,030
+طبعا واضح ان ال post operative بيكون فيها تعقيم و
+
+33
+00:03:16,030 --> 00:03:20,190
+الجراح بيكون معقم و أدواته معقمة لكن ال post
+
+34
+00:03:20,190 --> 00:03:24,990
+operative اللي ضرب سكينة و شوكة و حجر في عينه و
+
+35
+00:03:24,990 --> 00:03:29,490
+دخل الحجر هذا البكتيريا او السكينة طبعا هذه ملوثة
+
+36
+00:03:29,490 --> 00:03:35,140
+خطيرة يعنيطيب الشيء التالت root of infection طريقة
+
+37
+00:03:35,140 --> 00:03:40,020
+العدوى هل ان هذه البكتيريا اللي خشت مثلا اجت من
+
+38
+00:03:40,020 --> 00:03:46,840
+برا يعني من خارج العين ولا من داخل الجسم نفسه من
+
+39
+00:03:46,840 --> 00:03:55,620
+داخل الجسم يعني مثلا واحد يعني بيكار دخل في عين
+
+40
+00:03:55,620 --> 00:04:02,680
+والبيكار هذا ملوث او سن سرنجةدخل في عينه ملوث هذا
+
+41
+00:04:02,680 --> 00:04:08,260
+اكس جونس هذا ايش اكسه من برا ايش يعني طيب واحد
+
+42
+00:04:08,260 --> 00:04:14,840
+معاه دمل في الرئة او دمل في الكبل وهذا الدمل في
+
+43
+00:04:14,840 --> 00:04:19,840
+صديق وبكتيريا حملها الدم ودخلها على العين هذا اندو
+
+44
+00:04:19,840 --> 00:04:25,620
+من داخل الجسم اندو يعني اندو من جوا طيب الشيء
+
+45
+00:04:25,620 --> 00:04:30,560
+الرابع في التكسيبة بتاعة الحسب specific infectious
+
+46
+00:04:30,560 --> 00:04:36,820
+agent specific يعني فيه حاجات معينة يعني زي مثلا
+
+47
+00:04:36,820 --> 00:04:41,540
+ال syphilis ال syphilis اه يعني هذا اللي بيكون فيه
+
+48
+00:04:41,540 --> 00:04:45,240
+syphilis ممكن انه ينتج للعين و يعمل endothelmitis
+
+49
+00:04:45,240 --> 00:04:52,560
+حاجات نادرة هنا يعني فعلا في شيءاسمه pan of
+
+50
+00:04:52,560 --> 00:05:01,380
+salmites ايش الفرق بين pan و بين endo ال endo يعني
+
+51
+00:05:01,380 --> 00:05:06,040
+بكتيريا مثلا دخلت العين و اتكاترت عين الصليب لكن
+
+52
+00:05:06,040 --> 00:05:13,700
+pan كل أجزاء العين أصابها ال infection sclera و
+
+53
+00:05:13,700 --> 00:05:18,760
+الكورنيا و ما بينهما يعني هذه الكورنيا هيك وهي
+
+54
+00:05:18,760 --> 00:05:26,050
+sclera هيكوما بينهما يعني هذا صعب من هنامن هنا و
+
+55
+00:05:26,050 --> 00:05:29,810
+من هنا و من هنا و من هنا و من هنا و من هنا و من
+
+56
+00:05:29,810 --> 00:05:30,690
+هنا و من هنا و من هنا و من هنا و من هنا و من هنا و
+
+57
+00:05:30,690 --> 00:05:35,270
+من هنا و من هنا و من هنا و من هنا و من هنا و من
+
+58
+00:05:35,270 --> 00:05:37,330
+هنا و من هنا و من هنا و من هنا و من هنا و من هنا و
+
+59
+00:05:37,330 --> 00:05:37,430
+من هنا و من هنا و من هنا و من هنا و من هنا و من
+
+60
+00:05:37,430 --> 00:05:38,110
+هنا و من هنا و من هنا و من هنا و من هنا و من هنا و
+
+61
+00:05:38,110 --> 00:05:45,370
+من هنا و من هنا و من هنا و من هنا و من هنا و من
+
+62
+00:05:45,370 --> 00:05:45,490
+هنا و من هنا و من هنا و من هنا و من هنا و من هنا و
+
+63
+00:05:45,490 --> 00:05:47,030
+من هنا و من هنا و من هنا و من هنا و من هنا و من
+
+64
+00:05:47,030 --> 00:05:47,290
+هنا و من هنا و من هنا و من هنا و من هنا و من هنا و
+
+65
+00:05:47,290 --> 00:05:48,230
+من هنا و من هنا و من هنا و من هنا و من هنا و من
+
+66
+00:05:48,230 --> 00:05:51,670
+هنا و من هنا و من هنا
+
+67
+00:05:54,680 --> 00:05:58,880
+يعني احنا لو ادركنا الموضوع في ال endophthalmitis
+
+68
+00:05:58,880 --> 00:06:03,300
+ممكن نشيل القرنية و نفض العين و نخلص clear و
+
+69
+00:06:03,300 --> 00:06:07,520
+العضلات بركب عليها عين صناعية لكن لو صار pan of
+
+70
+00:06:07,520 --> 00:06:13,680
+thalmitis بدنا نخلع العين من وين من العصب من ورا
+
+71
+00:06:13,680 --> 00:06:17,620
+من هنا يعني
+
+72
+00:06:17,620 --> 00:06:20,760
+بدنا
+
+73
+00:06:20,760 --> 00:06:30,340
+نعمل إزالة لكل العينمش ازالة المحتويات العين اه اه
+
+74
+00:06:30,340 --> 00:06:36,040
+eviseration لما انا بطلب المعلجة eviseration
+
+75
+00:06:36,040 --> 00:06:40,180
+eviseration يعني ان انا طلعت محتويات العين بس
+
+76
+00:06:40,180 --> 00:06:46,160
+وطلعت ال sclera ركبة تركب فيها اللي هو عين صناعية
+
+77
+00:06:47,180 --> 00:06:55,840
+لكن انيوكلياشن انيوكلياشن انيوكلياشن
+
+78
+00:06:55,840 --> 00:06:59,840
+انيوكلياشن انيوكلياشن انيوكلياشن انيوكلياشن
+
+79
+00:06:59,840 --> 00:07:00,420
+انيوكلياشن انيوكلياشن انيوكلياشن انيوكلياشن
+
+80
+00:07:00,420 --> 00:07:02,300
+انيوكلياشن انيوكلياشن انيوكلياشن انيوكلياشن
+
+81
+00:07:02,300 --> 00:07:06,260
+انيوكلياشن انيوكلياشن انيوكلياشن انيوكلياشن
+
+82
+00:07:06,260 --> 00:07:11,860
+انيوكلياشن انيوكلياشن
+
+83
+00:07:11,860 --> 00:07:19,150
+انيوكلياشن انيوكلياشن انيوكليو ال infection بياخد
+
+84
+00:07:19,150 --> 00:07:24,130
+من عند ال scleral cornea جدام كله بيصيبه ال
+
+85
+00:07:24,130 --> 00:07:28,530
+infection اه و يعني احنا بس بنتكلم عن ال
+
+86
+00:07:28,530 --> 00:07:31,050
+endophthalmitis الان مش عارف ما هي endophthalmitis
+
+87
+00:07:31,050 --> 00:07:34,290
+يعني كلامنا عن ال endo هاي عين فيها
+
+88
+00:07:34,290 --> 00:07:38,510
+endophthalmitis كلها صديق وهي عين فيها
+
+89
+00:07:38,510 --> 00:07:42,210
+endophthalmitis كلها صديق طيب انواع ال
+
+90
+00:07:42,210 --> 00:07:45,650
+endophthalmitis كنا post-operative بالغالب بعد
+
+91
+00:07:45,650 --> 00:07:51,090
+عملية جراحيةويعملت جراحية اللى بتشيل الادسة
+
+92
+00:07:51,090 --> 00:07:54,210
+الخربانة اللى داخل العين معظمها cataract يعني
+
+93
+00:07:54,210 --> 00:07:59,090
+بتشيل العدسة الخربانة اللى فيها cataract وجالين
+
+94
+00:07:59,090 --> 00:08:03,470
+منها glucoma جالين منها بتفتح فتحة لميت العين تمشي
+
+95
+00:08:03,470 --> 00:08:09,470
+ومايركفش ضغط العين بس 90% من اللى هو ال boss
+
+96
+00:08:09,470 --> 00:08:17,810
+operative cataract طبعا مهماعمله علاج للهندو
+
+97
+00:08:17,810 --> 00:08:23,310
+سالمايتس فهيكون النتيجة poor vision ان ماكانش انه
+
+98
+00:08:23,310 --> 00:08:28,690
+blindness يعني احنا من اول ما يبدأ العين ان ما
+
+99
+00:08:28,690 --> 00:08:33,530
+يشوف شوي غبش و يتألم ابن الحجوب مضادة حيوية جوا
+
+100
+00:08:33,530 --> 00:08:38,630
+العين و برا العين و في المحلولهو ممكن انه نشيله
+
+101
+00:08:38,630 --> 00:08:43,390
+البترياس ونحطله saline وكلام لكنه بيقول يعني ال
+
+102
+00:08:43,390 --> 00:08:48,370
+visual prognosis النتيجة النهائية غالبا poor
+
+103
+00:08:48,370 --> 00:08:55,230
+vision يعني نظر ضعيف ان نجحت ان ماكنش فيه عمى طيب
+
+104
+00:08:55,230 --> 00:08:59,250
+هنتكلم ال boss operative endothalamic اللي بتيجي
+
+105
+00:08:59,250 --> 00:09:03,710
+بعد الكترة احنا معظم العملية التجراحية اللي بيصير
+
+106
+00:09:03,710 --> 00:09:10,390
+فيها ال endothalamic هيCataract بقوللي انه في هذه
+
+107
+00:09:10,390 --> 00:09:14,490
+العملية انه في video الوصي يعني عمى الفيديو الوصي
+
+108
+00:09:14,490 --> 00:09:21,490
+يعني فقد البصر عمى في تلت اللي هو اللي اللي اللي
+
+109
+00:09:21,490 --> 00:09:26,410
+التلت المصابين بالendothermic بصيروا عمى يعني يعني
+
+110
+00:09:26,410 --> 00:09:34,720
+مثلا لو ستين واحد صابهمالاندوفالميتس ممكن يكونوا
+
+111
+00:09:34,720 --> 00:09:42,380
+عشرين منهم عميان بعد هيك و اربعين لحقهم بقول
+
+112
+00:09:42,380 --> 00:09:46,540
+لي انه الخطر بتاع الاندوفالميتس بعد ال cataract
+
+113
+00:09:46,540 --> 00:09:52,970
+surgery موجود حتى في الدول المتقدمةأه well
+
+114
+00:09:52,970 --> 00:10:00,210
+developed countries بنسبة من 0.05% إلى 3% من خمسة
+
+115
+00:10:00,210 --> 00:10:05,090
+على مية في المية إلى تلاتة في المية بيصيبهم ايش من
+
+116
+00:10:05,090 --> 00:10:10,190
+اللي عملوه لهم كترك بيصيبهم endothalmitis
+
+117
+00:10:10,190 --> 00:10:14,770
+بقولي من ومان ان ده كده بتيجي غالبا بتكون هي في
+
+118
+00:10:14,770 --> 00:10:20,390
+الكنجرة الطيبة اول ما تلاقي فتحة مشرة تدخل عشان
+
+119
+00:10:20,390 --> 00:10:24,620
+هيكقبل عملية جراحية احنا ايش بنعمل بنحاول انعقم
+
+120
+00:10:24,620 --> 00:10:30,440
+ونطهر الملتحمة يكويس يكويس يكويس حتى ما يخشش منها
+
+121
+00:10:30,440 --> 00:10:35,180
+شيء يعني لما تكون البكتيريا برا على سطح القرنية
+
+122
+00:10:35,180 --> 00:10:39,540
+وسطح الملتحمة شيء و لما تلاقي فتحة و تخش جوا العين
+
+123
+00:10:39,540 --> 00:10:44,970
+شيء اخربيقول انه في مجموع اسمها endothelmitis
+
+124
+00:10:44,970 --> 00:10:49,130
+retractomy study دراسة اللي هو ال endothelmitis
+
+125
+00:10:49,130 --> 00:10:55,410
+اللي بيعملو لهم إزالة للجسم الزرجالي بيقول انه 70%
+
+126
+00:10:55,410 --> 00:11:03,050
+من المزرعة بتكون positive اه positive ان عندي
+
+127
+00:11:03,050 --> 00:11:07,630
+بكتيريا البكتيريا محبوسة جوا العين وغالبا هذه
+
+128
+00:11:07,630 --> 00:11:12,560
+بتكونكواجوليز نيجاتيف يعني تفرش كواجوليز نظام
+
+129
+00:11:12,560 --> 00:11:16,500
+اجرام بسطف كوكاي اسمه Staphylococcus Epidermidis
+
+130
+00:11:16,500 --> 00:11:20,640
+Staphylococcus Epidermidis احنا خدناها قبل هيك ان
+
+131
+00:11:20,640 --> 00:11:26,900
+انت بتعيش على الجلب بتعيش على الجلب لكن
+
+132
+00:11:26,900 --> 00:11:33,360
+لو لجت فتحة في النمبس ودخلتها دي وقال ايه انت تصبح
+
+133
+00:11:33,360 --> 00:11:38,690
+خطيرة جدا يعني فرق ما تعيش على الجلب متعايشةمثالمة
+
+134
+00:11:38,690 --> 00:11:44,010
+هو بين ما تدخل داخلها وتعمل العمال بتاعتها لذلك
+
+135
+00:11:44,010 --> 00:11:51,550
+هذه ال focus epidermis هي المتهمة طيب النقطة
+
+136
+00:11:51,550 --> 00:11:55,690
+التالية من اندوفتالميتس تقول لي pseudophakic
+
+137
+00:11:55,690 --> 00:12:01,130
+bacteria لاندوفتالميتس احنا عارفين فاكيا يعني
+
+138
+00:12:01,130 --> 00:12:05,110
+العدسة الأصلية موجودة لما تكون العدسة الأصلية
+
+139
+00:12:05,110 --> 00:12:15,110
+موجودةA هنا و العين هذه FAKE EYES طيب لو انضربت
+
+140
+00:12:15,110 --> 00:12:19,930
+هذه العدسة و سقطت مثلا هنا بيصير هذه A FAKE EYES
+
+141
+00:12:19,930 --> 00:12:26,510
+بحطها A A FAKE EYES طيب لو شننا العدسة و ركبنا
+
+142
+00:12:26,510 --> 00:12:32,510
+عدسة صناعية اللي لها زنبرة كيكمركّبنا عدسة صناعية
+
+143
+00:12:32,510 --> 00:12:38,510
+هذي بيصير سودو فاكهة سودو فاكهة عدسة صناعية مركبة
+
+144
+00:12:38,510 --> 00:12:41,690
+بدل الأصلية أما الأفاكهة مافيش عدسة بالمرة
+
+145
+00:12:41,690 --> 00:12:47,390
+والفاكهة هو الطبيعي بيقول
+
+146
+00:12:47,390 --> 00:12:52,890
+لي انه لجوا ان كتير من العدسات اللي بيصيرها
+
+147
+00:12:52,890 --> 00:12:56,970
+implantation بيزرعوها يعني جوا العين بدل عدسة
+
+148
+00:12:56,970 --> 00:13:02,720
+الخربانة اللي فيها كترةبتكون ملوثة كون تمانية اما
+
+149
+00:13:02,720 --> 00:13:08,480
+ملوثة مش معقمة كويس من مصنعها او هي expired يعني
+
+150
+00:13:08,480 --> 00:13:13,280
+لما يضعوا العدسة في البكيت بتاعها وبجانب اتنينه
+
+151
+00:13:13,280 --> 00:13:17,820
+بيكتبوا انه خلال ست شهور لازم تكون اتركبة في ناس
+
+152
+00:13:17,820 --> 00:13:20,820
+بيسأله مش عندهم كمية كبيرة بيقولك هو بيغير التاريخ
+
+153
+00:13:20,820 --> 00:13:25,400
+بعد سنتين بيركبها بتكون اشتلوثة يعني التعقيم
+
+154
+00:13:25,400 --> 00:13:33,230
+بيضمنهاش بعد ست شهور مثلابتعمل بكتيريا
+
+155
+00:13:33,230 --> 00:13:37,090
+الاندوفطالميتس تدخل البكتيريا تزرعها تعمل
+
+156
+00:13:37,090 --> 00:13:42,350
+اندوفطالميتس وتعمل نيكروتايزين كيراتايتس يعني إذا
+
+157
+00:13:42,350 --> 00:13:51,530
+بقى ليه القرانية مع موجود البكتيريا داخل العين
+
+158
+00:13:51,530 --> 00:13:58,240
+نيكروتايزين كيراتايتسو الـ stroma و كله بيحصل في
+
+159
+00:13:58,240 --> 00:14:02,400
+نكروزيس يعني إذابة نكروت ال tissue ل ال stroma
+
+160
+00:14:02,400 --> 00:14:05,940
+until ال stroma و بصير ال stroma و كله بيحصل في ال
+
+161
+00:14:05,940 --> 00:14:10,800
+diet هاي مثال لل pseudophytic bacterial
+
+162
+00:14:10,800 --> 00:14:14,340
+endocrinitis شوفوا يعني كيف الوضع هنا و كيف الوضع
+
+163
+00:14:14,340 --> 00:14:20,760
+هنا وضع كئيف جدا من الصديق طيب النقطة التالت من ال
+
+164
+00:14:20,760 --> 00:14:26,260
+endocrinitis بعد اللي هو past filtrationال boss
+
+165
+00:14:26,260 --> 00:14:29,560
+filtration يعني انه عملنا احنا مصفة في حالة
+
+166
+00:14:29,560 --> 00:14:34,680
+جلوكومة بنعمل filter اسمه يعني جراحة مثلا ايه اه
+
+167
+00:14:34,680 --> 00:14:37,080
+في الجلوكومة بنجي احنا بنفتح petra bicarb مش food
+
+168
+00:14:37,080 --> 00:14:42,620
+org فتحة هيك قناع عشان يسهل خروج الأكل و ال humor
+
+169
+00:14:42,620 --> 00:14:46,140
+من ال bistruit chamber الى ال interior chamber الى
+
+170
+00:14:46,140 --> 00:14:46,520
+ال angle
+
+171
+00:14:50,660 --> 00:14:57,800
+الشركة قامت بتفتح بيئة جديدة للبكتيريا لتخش من
+
+172
+00:14:57,800 --> 00:15:03,140
+الملتحمة البكتيريا
+
+173
+00:15:03,140 --> 00:15:06,560
+الاندروفنالمايتس باد لجلوكومه سيرجيري اسمه filter
+
+174
+00:15:09,660 --> 00:15:13,120
+زادت في الفترة الأخيرة لان احنا عملنا Trapeziotomy
+
+175
+00:15:13,120 --> 00:15:17,240
+Trapeziotomy هو هذا الشباك اللى بنعمله قطع في
+
+176
+00:15:17,240 --> 00:15:20,740
+Trapeziotomy مشوار عند ال upper limbus عارفين
+
+177
+00:15:20,740 --> 00:15:24,260
+upper limbus اللى هو هنا يعني هذا ال limbus كله
+
+178
+00:15:24,260 --> 00:15:27,860
+هنا ال upper limbus بنعمل نافلة يعني هذه النافلة
+
+179
+00:15:27,860 --> 00:15:33,810
+بتربطبين الـ Antelope Chamber وبين الملتحمة طب
+
+180
+00:15:33,810 --> 00:15:38,270
+الملتحمة كتير فيها ميكروبيات وبكتيريا بتخش يعني في
+
+181
+00:15:38,270 --> 00:15:41,090
+العيه دي بيكون في anatomic barrier احنا ال
+
+182
+00:15:41,090 --> 00:15:45,730
+anatomic barrier هذا الحاجز التشريحي احنا وقفناه
+
+183
+00:15:45,730 --> 00:15:49,170
+او قطعناه وبالتالي صارت السهل البكتيريا تخش من
+
+184
+00:15:49,170 --> 00:15:53,170
+الملتحمة الى ال antelope chamber وتعمل endothermia
+
+185
+00:15:53,170 --> 00:16:02,270
+يبقى صار في portal social portalيعني مدخل افتراضي
+
+186
+00:16:02,270 --> 00:16:06,630
+اه في الجطح هذا اللي عملناه بتربيكلر مش ورق
+
+187
+00:16:06,630 --> 00:16:09,750
+البكتيريا اللي بتخش في الموضوع هذا اسمها
+
+188
+00:16:09,750 --> 00:16:13,450
+hemophilus influenza اكتر اشي hemophilus influenza
+
+189
+00:16:13,450 --> 00:16:18,490
+بكتيريا وstriptococcus species أنواع الستربتوككية
+
+190
+00:16:18,490 --> 00:16:25,370
+اللي بتكون في الملتحمة ومتعايشة بتخش جوا الى داخل
+
+191
+00:16:25,370 --> 00:16:27,550
+ال interior chamber
+
+192
+00:16:29,620 --> 00:16:34,520
+هي عملية filter شايفين هى قطعنا هنا احنا قطع في
+
+193
+00:16:34,520 --> 00:16:39,400
+الترابيكو المشوار وفتحنا فتحة اللى السائري يجى من
+
+194
+00:16:39,400 --> 00:16:42,780
+ورا بيصير ال chamber و الاكل في ال chamber و يخش
+
+195
+00:16:42,780 --> 00:16:47,920
+في المتحمة و المتحمة بتصرفه مع الدم فبقول انه
+
+196
+00:16:47,920 --> 00:16:53,000
+وجدوا كتير من العينين اللى صار في endothelamitis
+
+197
+00:16:53,000 --> 00:16:56,580
+بعد عملية القطع هذا في الترابيكو المشوار
+
+198
+00:16:56,580 --> 00:17:04,170
+endothelamitisشافوا كثير من حالات صديرية التهاب
+
+199
+00:17:04,170 --> 00:17:08,430
+صديري و زي هذا التهاب الصديري بالظبط زي post
+
+200
+00:17:08,430 --> 00:17:13,150
+cataract endothalamic يعني النتيجة واحدة صدير داخل
+
+201
+00:17:13,150 --> 00:17:17,730
+العين وبكتيريا كانت في مزرعة بس داخل العين يعني in
+
+202
+00:17:17,730 --> 00:17:18,490
+vivo
+
+203
+00:17:21,870 --> 00:17:26,930
+بس بقوللي الفرق بين cataract ومن الجلوكومة ان ال
+
+204
+00:17:26,930 --> 00:17:30,890
+cataract في خلال اسبوع بتكون ساعة اندفترامات
+
+205
+00:17:30,890 --> 00:17:34,050
+أسكندراتية لكن الاندفترامات اللي post
+
+206
+00:17:34,050 --> 00:17:37,490
+-trabeculectomy اللي بعد الجلوكومة قطع الجلوكومة
+
+207
+00:17:37,490 --> 00:17:41,770
+trabeculectomy ممكن تصير بعد شهور أو بعد سنين بعد
+
+208
+00:17:41,770 --> 00:17:47,860
+شهور أو بعد سنين وهذا الخطر فيه يعنيالمريض ممكن
+
+209
+00:17:47,860 --> 00:17:51,060
+يعمله عملية ويمشي الحال وضغط الأيام بتاعه يكون
+
+210
+00:17:51,060 --> 00:17:55,800
+كويس من الجلوكومة وبعد ست شهور او سنة اللاجئ عينه
+
+211
+00:17:55,800 --> 00:17:58,220
+انتج صديد وهذه ستكون الفاجأة لكن بالنسبالي
+
+212
+00:17:58,220 --> 00:18:01,620
+الكاتراكت احنا بنعمله عملية ونخلي اسبوع تحت
+
+213
+00:18:01,620 --> 00:18:06,880
+المراقبة ان مضى اسبوع بكون مر بسلام والبكتيريا ما
+
+214
+00:18:06,880 --> 00:18:11,960
+دخلت في عينه يعني ال boss كاتراكت اكتر امانا من ال
+
+215
+00:18:11,960 --> 00:18:14,740
+boss الترابيكليكتومي بتاع الجلوكومة
+
+216
+00:18:16,880 --> 00:18:22,200
+طيب قصة traumatic يعني ولاد صغير بيلعب في بيكار
+
+217
+00:18:22,200 --> 00:18:27,000
+ولاد صغير بيلعب في حجار بيلعبوا في سكين أكل
+
+218
+00:18:27,000 --> 00:18:31,520
+بيلعبوا في الشوكت أثناء الطعام دخل اللي قال الحد
+
+219
+00:18:31,520 --> 00:18:34,880
+هالي في العين حادث اسمه trauma طب ال trauma إيش
+
+220
+00:18:34,880 --> 00:18:38,360
+بعدها بيصير post because of somitis بعد ال
+
+221
+00:18:38,360 --> 00:18:42,180
+accidental injury بعد الحادث هذا اللي صار في العين
+
+222
+00:18:44,260 --> 00:18:49,180
+خاصة لما يحصل حرق العين من ناحية القرانية غالبا
+
+223
+00:18:49,180 --> 00:18:55,220
+Penetrating trauma يعني ضربة نافلة من العين هو
+
+224
+00:18:55,220 --> 00:19:00,940
+risk خطر منه انه يعمل endocrinitis طبعا لكن العديد
+
+225
+00:19:00,940 --> 00:19:07,700
+انه بالدراسة مثلا على 82 واحد لجوا بس من خارجة
+
+226
+00:19:07,700 --> 00:19:12,410
+تانيهم اتنين بس من صابوا في دراسة تانيةيعني
+
+227
+00:19:12,410 --> 00:19:20,210
+reproductive study يعني دراسة مسبقة من ال 122 لجوا
+
+228
+00:19:20,210 --> 00:19:26,730
+بس 4 عيني قالوا طب بقول يعني انه يعني هال .. هال
+
+229
+00:19:26,730 --> 00:19:31,530
+بيكر او هذا اللي دخل بس يعني 4 من 122 او 2 من 82
+
+230
+00:19:31,530 --> 00:19:38,470
+قالوا اه ليش قالوا في اسباب السبب الأول انه أول ما
+
+231
+00:19:38,470 --> 00:19:43,210
+تنصب العينبيجيوا جاي على المستشفى عشان يسكروه
+
+232
+00:19:43,210 --> 00:19:50,050
+micro surgical repair of the wound repair يعني
+
+233
+00:19:50,050 --> 00:19:57,310
+خياطة خياطة repair خياطة للجرح مش موجود انه انضرب
+
+234
+00:19:57,310 --> 00:20:01,170
+في عينه نسيه مياه عينه و انه يخلوه يقعد في الدار
+
+235
+00:20:01,170 --> 00:20:07,230
+افندي لانه ألم شديد و بشوفش فكل
+
+236
+00:20:07,230 --> 00:20:11,300
+ما لاحظوا على المستشفى و خياطوله الجرحكل ما جلبت
+
+237
+00:20:11,300 --> 00:20:14,020
+تمال دخول البكتيريا انها تعمل انتصار متس داخلها
+
+238
+00:20:14,020 --> 00:20:18,980
+التاني effective antibiotic يعني هذا مش بس هم
+
+239
+00:20:18,980 --> 00:20:26,120
+بخيطونه بعتوا antibiotic في عينه مضاد حيوي قطرة
+
+240
+00:20:26,120 --> 00:20:30,640
+مضاد حيوي حجم ومضاد حيوي في المحلول اللي بركبه في
+
+241
+00:20:30,640 --> 00:20:36,420
+الوريد فهذا ال antibiotic بيكون effective يعني أيش
+
+242
+00:20:36,420 --> 00:20:41,930
+يعني قوي ومؤثرفهذا بنقض العين بعد الحادث او اختراق
+
+243
+00:20:41,930 --> 00:20:46,970
+العين بأي آلة حادة انها تعمل اندروس هالمانتزا
+
+244
+00:20:46,970 --> 00:20:51,770
+البكتيريا اللى في الحالات بتاعة ال accidental او
+
+245
+00:20:51,770 --> 00:20:56,310
+post traumatic infections اللى شائعة ريوها على غير
+
+246
+00:20:56,310 --> 00:21:02,790
+شكل اسمه باسيلاس سيرياس باسيلاس سيرياس ال most
+
+247
+00:21:02,790 --> 00:21:07,460
+common isolate يعني اللى تم اختشافها وعزلهافي خمسة
+
+248
+00:21:07,460 --> 00:21:11,680
+الى ست حلق من ال boss traumatic endophthalmitis
+
+249
+00:21:11,680 --> 00:21:19,520
+boss traumatic endophthalmitis هاي
+
+250
+00:21:19,520 --> 00:21:26,840
+جرح في العين نافذ اه و بده خياطة بده ورز عشان نمنع
+
+251
+00:21:26,840 --> 00:21:32,520
+البكتيريا ان تعيش فيه متغرض الشلال يعني ساعات تصير
+
+252
+00:21:32,520 --> 00:21:35,240
+مشكلة تصير ذوي الهدف endophthalmitis
+
+253
+00:21:39,930 --> 00:21:45,410
+طيب بقول انه يعني البكتيريا هذه المثلة ال serious
+
+254
+00:21:45,410 --> 00:21:50,670
+هي gram positive spore forming يعني انت تقدر في
+
+255
+00:21:50,670 --> 00:21:59,590
+حالة عدم وجود الطعام و تكون يعني فيها جفاف او حامض
+
+256
+00:21:59,590 --> 00:22:03,230
+او قلوي تعمل sport و sport أخدناه في خلية
+
+257
+00:22:03,230 --> 00:22:08,390
+البكتيريا في البدايةيبقى هي موجودة في الميه موجودة
+
+258
+00:22:08,390 --> 00:22:14,530
+في التربة موجودة في أماكن كثيرة بتلوث الأسطح حقيقة
+
+259
+00:22:14,530 --> 00:22:19,690
+اه وموجودة common soil bacterium يعني هي في التربة
+
+260
+00:22:19,690 --> 00:22:28,170
+والرمل موجودة لكثر وإلها toxins اهبلا جوه
+
+261
+00:22:28,170 --> 00:22:34,190
+التوكسينز هاري السموم في ال wound في العين او في
+
+262
+00:22:34,190 --> 00:22:40,010
+الجلب العالى ليه يقول باسيلا سيرياس اه لها توكسينز
+
+263
+00:22:40,010 --> 00:22:46,090
+طيب النوع الخامس من ال endothalamic metastatic
+
+264
+00:22:46,090 --> 00:22:51,330
+متستاتيك يعني انه من داخل الجسم انتقل من عضو إلى
+
+265
+00:22:51,330 --> 00:22:55,520
+عضو عن طريق الدم مثلايعني مثلا في دمال في الكبس
+
+266
+00:22:55,520 --> 00:23:00,200
+دمال في الرئة دمال في المخ و الدمال هذا فيه
+
+267
+00:23:00,200 --> 00:23:05,240
+بكتيريا تمكّن فيك تتحرر من الدمال و تدخل في الدم و
+
+268
+00:23:05,240 --> 00:23:08,560
+تعمل بكتيريميا بكتيريميا يعني بكتيريا in blood
+
+269
+00:23:08,560 --> 00:23:14,940
+بكتيريا in blood طبعا هتمشي وين ما هتصل هتعمل ايش
+
+270
+00:23:14,940 --> 00:23:19,660
+infection طب لو وصلت هي العين عن طريق ال central
+
+271
+00:23:19,660 --> 00:23:28,450
+retinal arteryفتمت سيرياص disease او ال داخل العين
+
+272
+00:23:28,450 --> 00:23:35,110
+يعني ال metastatic مع انه minority of septic
+
+273
+00:23:35,110 --> 00:23:40,310
+patients بيعملوه يعني جديد جدا الا انه وارد انه
+
+274
+00:23:40,310 --> 00:23:47,340
+تصير يعني وارد انه لو واحد عنده دمل داخل جسمهوطلعت
+
+275
+00:23:47,340 --> 00:23:51,320
+البكتيريا من دمها لعمل بكتيريميا في الدم ان اتصل
+
+276
+00:23:51,320 --> 00:23:55,520
+تعمل intraocular infection تعمل عجوة داخل العين
+
+277
+00:23:55,520 --> 00:24:02,880
+الميترستيك اندوستالميتس في بحث انه من 101 حالة
+
+278
+00:24:02,880 --> 00:24:07,280
+عندهم يعني مثلا lung abscess او liver abscess
+
+279
+00:24:07,280 --> 00:24:12,760
+رجعوا حالة واحدة عملت اندوستالميتس ممكن انه راحت
+
+280
+00:24:12,760 --> 00:24:18,660
+على اجزاء اخرى من جسم يعني عملته مثلاانفكشن في
+
+281
+00:24:18,660 --> 00:24:24,560
+منتجة تانية انفكشن في الرأى في المخ في الكبك في
+
+282
+00:24:24,560 --> 00:24:30,480
+المعدة في القلون في البنكرياس ممكن لكن بالنسبة
+
+283
+00:24:30,480 --> 00:24:34,400
+للعين لأن الاتري دي جديد تاني السمك تاني الاتري
+
+284
+00:24:34,400 --> 00:24:38,800
+يعني جليد بتخش البكتيريا وبتعمل endophthalmitis
+
+285
+00:24:38,800 --> 00:24:44,390
+هذا بيجي عن طريق سمك سمك انبولايSeptic Hemorrhage
+
+286
+00:24:44,390 --> 00:24:50,330
+يعني بتكون اللى طلعت من الدمل اللى بتحمل البكتيريا
+
+287
+00:24:50,330 --> 00:24:55,550
+دلطات او سددات صغيرة بتخش من الـ central retinal
+
+288
+00:24:55,550 --> 00:25:02,790
+artery اسمها Rot Spots زى اصغر من اصغر حبة رمل
+
+289
+00:25:02,790 --> 00:25:06,350
+ودخلت من ال central retinal artery عشان تعمل
+
+290
+00:25:06,350 --> 00:25:09,850
+endophthalmic لأن ال central retinal artery يعني
+
+291
+00:25:09,850 --> 00:25:15,610
+ال diameter بتاعه أجل من نص مليمتريعني بدخلش جلقات
+
+292
+00:25:15,610 --> 00:25:22,310
+كبيرة لتدخل منه بيقول لي إيش هي ال metastatic لخمس
+
+293
+00:25:22,310 --> 00:25:26,570
+البكتيريا اللي بتكون حاملها كتير بكتيريا ممكن حسب
+
+294
+00:25:26,570 --> 00:25:30,530
+الدم اللي في داخل الجسم Staphylococcus aureus
+
+295
+00:25:30,530 --> 00:25:34,670
+Staphylococcin pneumonia يعني معظم Staphylococcus
+
+296
+00:25:34,670 --> 00:25:38,470
+و Staphylococcus فيه خمسين إلى خمسة وسبعين في
+
+297
+00:25:38,470 --> 00:25:42,720
+المية من البكتيرياكلها جرام نيجاتي بوظتيف لكن جرام
+
+298
+00:25:42,720 --> 00:25:46,540
+نيجاتي أجالي منها إكليبسيلة سيو دو موناس اديونوزا
+
+299
+00:25:46,540 --> 00:25:50,640
+كلمنا عنها في القوانين الألصار جمال هيك وإكليبسيلة
+
+300
+00:25:50,640 --> 00:25:56,360
+كل هذا اي كولاي إشريشيا كولاي أنيساريا مينجايتسأه
+
+301
+00:25:56,360 --> 00:26:00,000
+بتشكل 900 ميلي جرام نيجاتيف يبقى هي في جرام
+
+302
+00:26:00,000 --> 00:26:03,880
+positive بكتيريا قد تكون ساكنة جوا الجسم أو جرام
+
+303
+00:26:03,880 --> 00:26:08,260
+negative اللى بتحرر من الدمال و بيطلع بيعمل
+
+304
+00:26:08,260 --> 00:26:14,120
+امبولايسيبتك و بيروح على العين سواء جرام positive
+
+305
+00:26:14,120 --> 00:26:20,560
+او جرام negative و اللى في اخر 15 سنة لجبلة
+
+306
+00:26:20,560 --> 00:26:24,020
+الفسيلة زادة اندوية نفسي يعني من داخل دمام الجسم
+
+307
+00:26:24,560 --> 00:26:29,950
+وانطلقت للعين اه هي زادت لأسباب غير معلومةبقول من
+
+308
+00:26:29,950 --> 00:26:32,830
+العوامل المساعدة انه يكون عنده سكري diabetes
+
+309
+00:26:32,830 --> 00:26:36,770
+mellitus ومنعته جليل هذا المريض او عنده liver
+
+310
+00:26:36,770 --> 00:26:41,050
+abscess او liver abscess يعني دم الكبلي وممكن lung
+
+311
+00:26:41,050 --> 00:26:45,290
+abscess كتير برضه اه هو risk factor يعني عوامل خطر
+
+312
+00:26:45,290 --> 00:26:47,930
+انه هذا اللي ماعاد diabetes mellitus او liver
+
+313
+00:26:47,930 --> 00:26:52,050
+abscess انه تنتقل البكتيريا بشكل metastatic
+
+314
+00:26:52,050 --> 00:26:55,550
+bacteria endophthalmatis للعيال طيب ايش بقولي
+
+315
+00:26:55,550 --> 00:27:00,420
+اشياء بتساعديعني او بتحدد انه هذه البكتيريا تستطيع
+
+316
+00:27:00,420 --> 00:27:05,140
+انها تعمل في العين يعني endothalmitis يعني بكتيريا
+
+317
+00:27:05,140 --> 00:27:08,160
+تمليها بكتيريا ولا لا ال virulence اذا كان والله
+
+318
+00:27:08,160 --> 00:27:13,320
+البكتيريا virulent يعني شرسة و قوية بتعمل بعدين
+
+319
+00:27:13,320 --> 00:27:18,620
+الوقت اللذي يمر ما بين infection و ال examination
+
+320
+00:27:18,620 --> 00:27:23,910
+والله في واحد اول ما عينه تتقلم و بروح بيجريهو
+
+321
+00:27:23,910 --> 00:27:27,030
+بيكرر في النظر عنده و بيروح يجري و في واحد بعد شهر
+
+322
+00:27:27,030 --> 00:27:30,690
+لما يسأل لما تخرب عينه لما يروح يعمل examination
+
+323
+00:27:30,690 --> 00:27:34,830
+في المستشفى او عند طبيب مقتصر effectiveness of
+
+324
+00:27:34,830 --> 00:27:38,400
+treatment يعني مش كل واحد اعطى علاج اعطى علاجوالله
+
+325
+00:27:38,400 --> 00:27:43,220
+اندفنالمايتس علاجه يجب ان يكون علاج قوي جدا و من
+
+326
+00:27:43,220 --> 00:27:46,800
+البداية اما العلاج الطب طبعه يعني بس مجرد خطرات و
+
+327
+00:27:46,800 --> 00:27:53,620
+كلام antibiotic مانفعش قد نحتاج ان نعمل removal of
+
+328
+00:27:53,620 --> 00:27:57,230
+the vitreous في التريكتوميبتركتمي انه نشيل
+
+329
+00:27:57,230 --> 00:28:01,410
+الفيترياس كله ونحط انتيبويتك ومحلي البداله حتى
+
+330
+00:28:01,410 --> 00:28:05,270
+نجدي على البكتيريا اللي داخل العين فمش اي علاج ولا
+
+331
+00:28:05,270 --> 00:28:10,730
+وقت العلاج يكون طويل لازم نلحقه بسرعة اخر قشعة
+
+332
+00:28:10,730 --> 00:28:14,710
+location of septic embolism يعني هي وين اللي جاية
+
+333
+00:28:14,710 --> 00:28:21,530
+هل هي جاية في الفيترياس ولا هي جاية في الرتنة ولا
+
+334
+00:28:21,530 --> 00:28:28,430
+جاية في blood vessel بتاع الرتنةولا جاية يعني داخل
+
+335
+00:28:28,430 --> 00:28:33,010
+الكروج حسب كل ما كانت داخل العين اكتر كل ما عندك
+
+336
+00:28:33,010 --> 00:28:38,710
+عملة ban of thalmitis صديقي طيب
+
+337
+00:28:38,710 --> 00:28:44,310
+هذه الصورة ban of thalmitis ban يعني هذا خلاص كل
+
+338
+00:28:44,310 --> 00:28:48,730
+عين بدها جرف مافيها كلام هذه يعني العين هذه لازم
+
+339
+00:28:48,730 --> 00:28:54,560
+تتدحط وتطلع برابما فيها سكليرة والعضلات كله كله من
+
+340
+00:28:54,560 --> 00:28:58,480
+عند العصب من ورا انا بشكركم على فرصة الاستماع لهذه
+
+341
+00:28:58,480 --> 00:29:03,420
+المحاضرة الشيقة واسأل الله عز وجل انه يكونوا
+
+342
+00:29:03,420 --> 00:29:08,000
+استفدتوا من هذه المحاضرة واحنا نتواصل معاكم
+
+343
+00:29:08,000 --> 00:29:13,500
+باستمرار ان شاء الله نتواصل معاكم باستمرار الى انه
+
+344
+00:29:13,500 --> 00:29:14,500
+نصل الاخر محاضرة
+
diff --git a/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/LWHQ2dWz8vI_postprocess.srt b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/LWHQ2dWz8vI_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..bc4af773b87bce8971b08af3c96a9e9418fdf97a
--- /dev/null
+++ b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/LWHQ2dWz8vI_postprocess.srt
@@ -0,0 +1,1280 @@
+1
+00:00:05,570 --> 00:00:08,750
+أعوذ بالله من الشيطان الرجيم بسم الله الرحمن
+
+2
+00:00:08,750 --> 00:00:13,550
+الرحيم الحمد لله و أقف أصلي و أسلم على النبي مصطفى
+
+3
+00:00:13,550 --> 00:00:18,310
+أبدأ اليوم في المحاضرة الثلاثين في هذا المساق
+
+4
+00:00:18,310 --> 00:00:27,050
+microbiology of the eye ال herpes simplex virus هو
+
+5
+00:00:27,050 --> 00:00:33,660
+أشهر فيروس يصيب العينيعني البرنامج الأخرى تصيب
+
+6
+00:00:33,660 --> 00:00:37,520
+العين لكن الهيربس simplex احنا حسب تجربة الاقليكية
+
+7
+00:00:37,520 --> 00:00:44,320
+بتاعتنا انه يصيب العين بصورة اكثر يعني تكررا حقيقة
+
+8
+00:00:44,320 --> 00:00:51,940
+هو double strand DNA يعني خلانا نتفق على ان كل
+
+9
+00:00:51,940 --> 00:00:56,640
+الأسرة هذه تحت الهيربس كلها DNA و double strand
+
+10
+00:00:56,640 --> 00:01:04,850
+فهو شبه باق العيلةDouble strand DNA حجمه كبير 150
+
+11
+00:01:04,850 --> 00:01:10,190
+-200 nano متر متعدد
+
+12
+00:01:10,190 --> 00:01:13,870
+الأوجه تقريبا
+
+13
+00:01:13,870 --> 00:01:19,250
+متشابه انا
+
+14
+00:01:19,250 --> 00:01:25,550
+عندي حاجتين نوعين النوع الأول one والنوع التاني
+
+15
+00:01:25,550 --> 00:01:30,420
+two انا عندي herpes simplex oneو همرس herpes
+
+16
+00:01:30,420 --> 00:01:35,380
+simplex 2 الهيربس
+
+17
+00:01:35,380 --> 00:01:40,380
+سيمبليكس وان هو الذي يختص بقرنية العين او بالعين
+
+18
+00:01:40,380 --> 00:01:46,920
+يختص بالعين عشان اسمه keratitis human يعني بصيب
+
+19
+00:01:46,920 --> 00:01:51,100
+اللي هو قرنية العين و بصيب الشفايف herpes labiatis
+
+20
+00:01:51,100 --> 00:01:54,360
+يعني بيعمل التهاب الشفاتين و التهاب القرنية
+
+21
+00:01:54,360 --> 00:01:58,940
+keratitis ال herpes simplex 2هي هتب السيمليكس
+
+22
+00:01:58,940 --> 00:02:02,640
+جينيكاليس يعني وصيب الأعضاء التناثورية يبقى فيه
+
+23
+00:02:02,640 --> 00:02:06,160
+هتب السيمليكس one وهمر السيمليكس two لما أقول one
+
+24
+00:02:06,160 --> 00:02:09,940
+يعني للشفاية في العين و لما أقول هتب السيمليكس two
+
+25
+00:02:09,940 --> 00:02:17,140
+يعني للجهاز التناثوري في الذكاء العلمي بقول
+
+26
+00:02:17,140 --> 00:02:23,340
+انه يعني في ميول للتو هذا ان وصيب ال genital
+
+27
+00:02:23,340 --> 00:02:30,220
+regions يعني الأعضاء التناثورية اهلكن ممكن انه
+
+28
+00:02:30,220 --> 00:02:34,040
+يتاخد من الأعضاء التناثورية على العين ويسيب العين
+
+29
+00:02:34,040 --> 00:02:38,460
+يبقى اللي احنا بيقوله ان اللي من العين غالبا
+
+30
+00:02:38,460 --> 00:02:40,660
+مايصيبش الأعضاء التناثورية لكن اللي من أعضاء
+
+31
+00:02:40,660 --> 00:02:45,960
+التناثورية ممكن يصيب العين وهذا سنشوفه قدام شوية
+
+32
+00:02:45,960 --> 00:02:49,320
+يبقى هذه الصورة ليه اللي هو الفيروسات بتصيب
+
+33
+00:02:49,320 --> 00:02:52,230
+الأعضاء التناثوريةهذه الفيروسات تصيب العضاء
+
+34
+00:02:52,230 --> 00:02:57,530
+التناثرية في الذكر والكونسا وهذا الهيرب السيمليكس
+
+35
+00:02:57,530 --> 00:03:02,630
+مكبر ألاف المرة طيب إبدايمولوجيا إيش يعني نواحي
+
+36
+00:03:02,630 --> 00:03:06,290
+الوبائية بتاعته بقول الهيرب السيمليكس infection
+
+37
+00:03:06,290 --> 00:03:10,850
+ممكن تكون في العقليات subclinical subclinical يعني
+
+38
+00:03:10,850 --> 00:03:16,810
+لا تبدو لها أعراض وعلامات بقول
+
+39
+00:03:16,810 --> 00:03:20,750
+إن في الوقت المتحدة الأمريكيةفي الخمسين او تمانية
+
+40
+00:03:20,750 --> 00:03:24,530
+في المية من الأشخاص أو المواطنين في الواقع المتحدة
+
+41
+00:03:24,530 --> 00:03:30,670
+الأمريكية وصابون بال virus one او two او كلاهما
+
+42
+00:03:30,670 --> 00:03:34,470
+ووجدوا
+
+43
+00:03:34,470 --> 00:03:41,320
+ان في دمهم فيه antibodies يعني أسهم ضغطةللـ Herpes
+
+44
+00:03:41,320 --> 00:03:48,800
+Simplex في اللي هو سن تلاتين سنة وقل سن تلاتين سنة
+
+45
+00:03:48,800 --> 00:03:53,540
+من الناس فانا جاي اصل تلاتين وانصابوا 80% من
+
+46
+00:03:53,540 --> 00:03:59,780
+المجتمع هو ممكن انا اقول انه يلاقوا في دمهم اللي
+
+47
+00:03:59,780 --> 00:04:04,140
+هو اللي
+
+48
+00:04:04,140 --> 00:04:08,750
+هو Antibodiesهذه الانتيبوديس اللى جوه ال serum
+
+49
+00:04:08,750 --> 00:04:14,250
+convention يعني انه يصل لدم الانتيبوديس لجسم
+
+50
+00:04:14,250 --> 00:04:18,670
+المضادة موجودة كتير في الفقراء اللى هو lower
+
+51
+00:04:18,670 --> 00:04:23,230
+socioeconomic groups في الفقراء أكتر من الأغنياء
+
+52
+00:04:23,230 --> 00:04:27,830
+والدول الغير متطورة لأنهم متعرضوا كتير للأمراض ومن
+
+53
+00:04:27,830 --> 00:04:34,310
+الفيروسات الحقيقة ان المشكلةالبروس هذا يختبئ في
+
+54
+00:04:34,310 --> 00:04:38,590
+التراجي من الجنجليون في منطقة اسمها Pons البروس
+
+55
+00:04:38,590 --> 00:04:38,650
+Pons البروس هذا يختبئ في التراجي من الجنجليون في
+
+56
+00:04:38,650 --> 00:04:38,870
+منطقة اسمها Pons البروس هذا يختبئ في التراجي من
+
+57
+00:04:38,870 --> 00:04:39,330
+الجنجليون في منطقة اسمها Pons البروس هذا يختبئ في
+
+58
+00:04:39,330 --> 00:04:40,050
+التراجي من الجنجليون في منطقة اسمها Pons البروس
+
+59
+00:04:40,050 --> 00:04:40,910
+هذا يختبئ في التراجي من الجنجليون في منطقة اسمها
+
+60
+00:04:40,910 --> 00:04:46,250
+Pons البروس هذا يختبئ في التراجي من الجنجليون في
+
+61
+00:04:46,250 --> 00:04:54,610
+منطقة اسمها Pons البروس هذا يختبئ في التراجي من
+
+62
+00:04:54,610 --> 00:05:01,390
+الجنجليون في منطقة اسمها Pons
+
+63
+00:05:02,620 --> 00:05:13,280
+وبلونجاتا هنا في في اليمين و الشمال من ال brain في
+
+64
+00:05:13,280 --> 00:05:20,900
+اللي هو ايش اللي هو الواء بتاعت اللي هو العصب
+
+65
+00:05:20,900 --> 00:05:26,980
+الخامس و اظن حتى بتاخد شوية من ال points من عصب
+
+66
+00:05:26,980 --> 00:05:32,880
+الخامسوبتخلع العصب هيك المهم ان الفيروس هذا يختبئ
+
+67
+00:05:32,880 --> 00:05:38,500
+في اللي هو ال midbrain او في ال Pons في النواة
+
+68
+00:05:38,500 --> 00:05:43,740
+Trigeminal جانجليون ولمّا الإنسان يضعف بيمشي مع
+
+69
+00:05:43,740 --> 00:05:48,880
+الشيط بتاع العصب وجروع القرانية وجروع عله اللي هو
+
+70
+00:05:48,880 --> 00:05:54,600
+ال lips وين اللي هو Phalmic nerve هو ال Trigeminal
+
+71
+00:05:54,600 --> 00:05:59,670
+nerve اللي له تلت أفرهاللي هو فرع اسمه ophthalmic
+
+72
+00:05:59,670 --> 00:06:05,170
+وفرع اسمه maxillary وفرع اسمه mandibular nerve فال
+
+73
+00:06:05,170 --> 00:06:09,990
+ophthalmic nerve هذا هو اللي بيغذي القرنية وبيغذي
+
+74
+00:06:09,990 --> 00:06:16,490
+lips اللي هو الشفاف لما
+
+75
+00:06:16,490 --> 00:06:21,370
+انتهي ال infection او بيأخد علاج ال virus بيهرب
+
+76
+00:06:21,370 --> 00:06:27,890
+وين تاني ويختبئ في المخفي الـ Pons هنا يختبئ او في
+
+77
+00:06:27,890 --> 00:06:32,070
+ال midbrain يختبئ لما يضعف ويسيبه مثلا اي ضعف
+
+78
+00:06:32,070 --> 00:06:34,990
+مناعي بعوض ينزل ويسيب القرانية عشان انكم تلاقي ان
+
+79
+00:06:34,990 --> 00:06:40,210
+مرض القرانية بالفيروس herpes simplex هنا كتير انه
+
+80
+00:06:40,210 --> 00:06:48,670
+يتكرر كل ما يفلوز او كل ما يسيبه ضعف مناعي طيب
+
+81
+00:06:48,670 --> 00:06:52,990
+بقول انه الانسان
+
+82
+00:06:53,890 --> 00:06:57,050
+ممكن ان يصيبوا ضعف المناعي و تكرروا ال herpes
+
+83
+00:06:57,050 --> 00:07:00,850
+simplex infection خاصة في مرضى ال AIDS يعني ال
+
+84
+00:07:00,850 --> 00:07:07,230
+AIDS بعطي فرصة لالميكروبات ال Portionistic بيقولوا
+
+85
+00:07:07,230 --> 00:07:11,150
+عنها الانتهازية ان هي تاخذوا الجسم حتى لما تكون لو
+
+86
+00:07:11,150 --> 00:07:15,710
+كانت commensal بتصير aggressive وبتصير يعني قادرة
+
+87
+00:07:15,710 --> 00:07:18,790
+على انها تفتك بالانسان فالانسان اللي عنده ال AIDS
+
+88
+00:07:18,790 --> 00:07:23,380
+ممكن جدا ال ويروسات هذه يتكرر عندهبتصير more
+
+89
+00:07:23,380 --> 00:07:30,720
+frequent انه تجيه كتير بقولنا احنا ال herpes
+
+90
+00:07:30,720 --> 00:07:37,480
+simplex 2 اللي بصيب الأعضاء التناثولية بكون
+
+91
+00:07:37,480 --> 00:07:41,140
+عنده resistance انه يصيب ال herpes simplex 1 يعني
+
+92
+00:07:41,140 --> 00:07:44,900
+لما الواحد انصاب في أحشائهفي المناطق التناثورية
+
+93
+00:07:44,900 --> 00:07:52,360
+صعبة يعني انه يصيب المنطقة هذه بSimplex one خلاص
+
+94
+00:07:52,360 --> 00:07:58,420
+ال two بس مفكر عليه لكن ال ال ال one ما بيسكر على
+
+95
+00:07:58,420 --> 00:08:01,520
+ال two يعني ممكن انه ينصاب من الأعضاء التناثورية
+
+96
+00:08:01,520 --> 00:08:05,240
+على العين لكن مش سهل ينصاب ياخد من العين ويحط في
+
+97
+00:08:05,240 --> 00:08:10,910
+أعضاء التناثورية يعني لو واحدحق عضاء التناثورية
+
+98
+00:08:10,910 --> 00:08:14,830
+وحق العين اه بنصاب بال herpes simplex 2 كمان لكن
+
+99
+00:08:14,830 --> 00:08:17,570
+لو أخد من عينه حق عينه وحق العضاء التناثورية
+
+100
+00:08:17,570 --> 00:08:23,130
+بانصابش في العضاء التناثورية وهذا يعني حاجة بدها
+
+101
+00:08:23,130 --> 00:08:29,610
+بحث علمي ليش هو السبب ال herpes simplex 1 هذا هو
+
+102
+00:08:29,610 --> 00:08:36,070
+المسؤول عن اصابات العين بكثرة ويقول ان 20% تقريبا
+
+103
+00:08:36,070 --> 00:08:41,300
+من المرضىبينصابوا حتى في stroma بتاعة القرنية
+
+104
+00:08:41,300 --> 00:08:45,960
+وممكن في ال endothelium يصيبهم عتامة على العين
+
+105
+00:08:45,960 --> 00:08:49,200
+ويصير عينهم opaque خاصة اذا كانت هناك recurrent
+
+106
+00:08:49,200 --> 00:08:53,000
+infection يعني متكررة ممكن يصيبهم stroma
+
+107
+00:08:53,000 --> 00:08:56,740
+الكيروتيتس وdiskey form keratitis يعني انتهاب
+
+108
+00:08:56,740 --> 00:09:02,820
+القنية القرصي وممكن انه يصير عتامة وعمىطيب ايش هي
+
+109
+00:09:02,820 --> 00:09:06,000
+ال clinical presentation ايش الاعراض والعلمات
+
+110
+00:09:06,000 --> 00:09:11,860
+جسمناها الى general و الى ocular general يعني في
+
+111
+00:09:11,860 --> 00:09:15,980
+الجسم كله و ocular فى العين بس طب ال ايش هي ال
+
+112
+00:09:15,980 --> 00:09:20,920
+general جنجيب و stomatitis يعني التهاب اللثة
+
+113
+00:09:20,920 --> 00:09:27,020
+والشفتين اللى بيقولونها labiatis مش بس الشفة الشفة
+
+114
+00:09:27,020 --> 00:09:35,470
+و مع الشفة ايشاللي هو الشفتين ال gum يعني أقصر
+
+115
+00:09:35,470 --> 00:09:41,130
+اللفتة pharyngitis افتهاب اللوز و البلعوم rhinitis
+
+116
+00:09:41,130 --> 00:09:44,870
+افتهاب الأنف الفيروسي tonsillitis افتهاب اللوزتين
+
+117
+00:09:44,870 --> 00:09:51,970
+لأن هم موجودين في الحلقة طيب هذه الحاجات نسميها
+
+118
+00:09:51,970 --> 00:09:56,630
+general يعني general و primary و general مصيبه
+
+119
+00:09:56,630 --> 00:10:02,060
+feverسخونة و chills راجفة وميال فياز التهاب اللي
+
+120
+00:10:02,060 --> 00:10:06,220
+هو ألم العضلات و lymph adrenopathy التهاب أو تضخم
+
+121
+00:10:06,220 --> 00:10:12,860
+لوقت النفوية في الرقبة على جانبي الرقبة كمان
+
+122
+00:10:12,860 --> 00:10:19,240
+اللي قولنا lips اللي هتسيبها vesicular eruptions
+
+123
+00:10:19,240 --> 00:10:24,610
+كلمة vesicular يعنيزي حليبات او اكياء سمائية فزيكل
+
+124
+00:10:24,610 --> 00:10:29,510
+فزيكل يعني فزي كيس مائي صغير على الشيباتين وكتير
+
+125
+00:10:29,510 --> 00:10:33,670
+من احنا بنصحي بهايها شايفين بيقولوا طلعلوا حم احنا
+
+126
+00:10:33,670 --> 00:10:37,770
+بيقول الصبح ايش البلد او البنت هتطلعله حم فزيكلر
+
+127
+00:10:37,770 --> 00:10:43,290
+ارفشن اه on lips ميوكير اه unresolved يعني بتطبخ
+
+128
+00:10:43,290 --> 00:10:46,730
+للاسمه بتطبخ للاسمه يبقى الست حاجات هذه general
+
+129
+00:10:46,730 --> 00:10:49,450
+انا مابركز على ال general لكن ممكن تجي بالصح
+
+130
+00:10:49,450 --> 00:10:53,750
+والغلط يعنيلكن ابركز على ال اوكلر اشي primary
+
+131
+00:10:53,750 --> 00:10:57,770
+اوكلر يعني primary لأول مرة يعني مش هننصاب كتير لأ
+
+132
+00:10:57,770 --> 00:11:03,850
+اول مرة اول مرة فيه follicular keratoconucleitis
+
+133
+00:11:03,850 --> 00:11:08,050
+يعني follicles احنا عارفين follicles يعني نفوقات
+
+134
+00:11:08,050 --> 00:11:13,810
+صغيرة مبروزات صغيرة على القرنية وعلى الملتحمة هذه
+
+135
+00:11:13,810 --> 00:11:20,930
+اول شيء ممكن يصيبهم lymphadenitis يعنياكتهاد العقل
+
+136
+00:11:20,930 --> 00:11:26,090
+النفوية على جانب أي رقبة الشيء الصعب يكون فيه
+
+137
+00:11:26,090 --> 00:11:29,690
+alternative diparitis يعني لو احنا شوفنا حواف
+
+138
+00:11:29,690 --> 00:11:35,690
+الجفن اللي فيه شعر رموش نجيها ملتهبة الأخطر أنه
+
+139
+00:11:35,690 --> 00:11:38,930
+يصير alternative keratitis يعني كونيا القلصة كونيا
+
+140
+00:11:38,930 --> 00:11:42,930
+القلصة خطيرة جدا وهذا ما نقول القرحة الشجرية
+
+141
+00:11:42,930 --> 00:11:46,830
+Dendritic ulcer فنشوفها كاملة شوية Dendritic ulcer
+
+142
+00:11:49,530 --> 00:11:54,250
+ذكروا اذن adenitis اللي هو التهاب الغضب الدمعية
+
+143
+00:11:54,250 --> 00:11:58,610
+التهاب الغضب الدمعية الكبرى اللي هي في المحجر من
+
+144
+00:11:58,610 --> 00:12:05,450
+ناحية ال upper lateral side احنا حتى الآن بتتكلم
+
+145
+00:12:05,450 --> 00:12:09,650
+على primary يبقى هذه primary واحد اثنين ثلاثة
+
+146
+00:12:09,650 --> 00:12:17,110
+اربعة خمسة هذه primary الان ستة مش منهم هذه ستة
+
+147
+00:12:17,110 --> 00:12:24,130
+كتبوهاإنه Recurrent Recurrent يعني صارت راحت وجهة
+
+148
+00:12:24,130 --> 00:12:27,290
+راحت وجهة infection يعني مرة جديدة ثلاثة أربعة
+
+149
+00:12:27,290 --> 00:12:30,550
+خلاص ماتت بقول انا Recurrent infections المتتابعة
+
+150
+00:12:30,550 --> 00:12:34,630
+بصير كون الإبتئام لل ulcers يعني الإبتئام بتاع
+
+151
+00:12:34,630 --> 00:12:39,310
+القرنية بتقرر وبخش على ال stroma يعمل interstitial
+
+152
+00:12:39,310 --> 00:12:43,510
+keratitis keratitis في ال stroma اه اللي اسمه
+
+153
+00:12:43,510 --> 00:12:46,990
+disceform keratitis هذا هو هذا disceform يعني زي
+
+154
+00:12:46,990 --> 00:12:51,770
+الشكل يعنيوهذا كيروتايتس وممكن يعمل تلايف وإيه ذو
+
+155
+00:12:51,770 --> 00:12:56,850
+سايكلايتس يدخل على جوا اللي هو ال iris وcellary
+
+156
+00:12:56,850 --> 00:13:02,050
+body إذا احنا جسمناهم إلى primary general و
+
+157
+00:13:02,050 --> 00:13:10,470
+primary ocular وكمان recurrent
+
+158
+00:13:10,470 --> 00:13:15,910
+يعني ممكن احنا نجسمهم هذه تلاتة هنعملهم وبعدين
+
+159
+00:13:15,910 --> 00:13:21,380
+نصليحهم هذه تلاتةrecurrent وهذه اثنين primary
+
+160
+00:13:21,380 --> 00:13:27,680
+primary ocular وهذه واحد primary general تكتب
+
+161
+00:13:27,680 --> 00:13:34,160
+primary general primary general طيب الكون ال
+
+162
+00:13:34,160 --> 00:13:38,680
+isolation هذه اخطر شيء انه او اكتر شيء بصيب
+
+163
+00:13:38,680 --> 00:13:42,460
+الانسان في ال virus service simplex خاصة one انه
+
+164
+00:13:42,460 --> 00:13:46,960
+تقرف القرانية ومن اخطر الأشياء اللي بتعمل عمهاأه
+
+165
+00:13:46,960 --> 00:13:50,640
+هو common manifestation common manifestation يعني
+
+166
+00:13:50,640 --> 00:13:56,100
+ظاهرة معتادة انه تصير في ال herpes simplex virus
+
+167
+00:13:56,100 --> 00:14:01,740
+اه وللأسف انها recurrent ليش قلنا ان الفيروس مايحس
+
+168
+00:14:01,740 --> 00:14:06,240
+قوة مناعة او بعلاج بيهرب وين في ال triangle من
+
+169
+00:14:06,240 --> 00:14:10,320
+الجنجل و في ال brain بالتحديد
+
+170
+00:14:10,320 --> 00:14:19,000
+في ال middle brain و ال ponsطيب الان ال infection
+
+171
+00:14:19,000 --> 00:14:23,020
+يعتقد
+
+172
+00:14:23,020 --> 00:14:27,920
+انها بتيجي من العصب خاصة من الفرع الأول ونقصان
+
+173
+00:14:27,920 --> 00:14:31,520
+مكنير بتاع الـ Trigeminal اللي بيغذي القرانية
+
+174
+00:14:31,520 --> 00:14:35,320
+والشفاية بيغذي القرانية والشفاية ال prognosis
+
+175
+00:14:35,320 --> 00:14:39,640
+المقال والمصير لأسف على ال vision 4يعني غالبا
+
+176
+00:14:39,640 --> 00:14:44,240
+هدولة بيؤدي الى تعتيم القرانية وصير very poor
+
+177
+00:14:44,240 --> 00:14:50,340
+vision خاصة مع تأخر التشخيص والعلاج يعني اللي
+
+178
+00:14:50,340 --> 00:14:54,560
+بيجينا على طبيب العيون من أولهابنحط الفلوريسين
+
+179
+00:14:54,560 --> 00:14:58,940
+وبين الخضار هذا اسمها Dendritic Ulcer على طول احنا
+
+180
+00:14:58,940 --> 00:15:02,960
+نعطيه زوبراكس نعطيه حاجات مضادة الفيروسات انتفيروس
+
+181
+00:15:02,960 --> 00:15:08,060
+ممكن يشفى خلال أسبوع أو أسبوعين لكن الأسف ان في
+
+182
+00:15:08,060 --> 00:15:12,140
+كتير من الناس delayed diagnosis يصير يروح يعني إلى
+
+183
+00:15:12,140 --> 00:15:16,410
+واحد ماعرفش يشخصبصير مش عارف ان هذا فيروس ممكن
+
+184
+00:15:16,410 --> 00:15:19,670
+يعطيه antibiotic او اي حاجة و الفيروس مايكترش فيه
+
+185
+00:15:19,670 --> 00:15:23,070
+ال antibiotic و ممكن يعمل destruction of the
+
+186
+00:15:23,070 --> 00:15:25,890
+cornea rapid destruction of the cornea خش من
+
+187
+00:15:25,890 --> 00:15:29,030
+الهيوتينا و من الastroma و من الastroma يخش على
+
+188
+00:15:29,030 --> 00:15:36,430
+اللي هو الداخل العين يعمل eridocyclitis طيب ال
+
+189
+00:15:36,430 --> 00:15:44,460
+corneal disease بتاعة ال herpesPD في ثلاث مناطق
+
+190
+00:15:44,460 --> 00:15:48,060
+المنطقة الخارجية Epithelium of the cornea المنطقة
+
+191
+00:15:48,060 --> 00:15:50,860
+الوسطى Stoma of the cornea المنطقة الداخلية
+
+192
+00:15:50,860 --> 00:15:54,020
+Endothelium of the cornea انا عارفين طبقات القرنية
+
+193
+00:15:54,020 --> 00:16:00,500
+الخامسة ماهي طبقات القرنية الخامسة Epithelium
+
+194
+00:16:00,500 --> 00:16:06,060
+باميز ممبرين Stoma Dysmys membrane Endothelium
+
+195
+00:16:06,060 --> 00:16:12,990
+مظبوط هكذابصيبه ذوبان Latin Infection يعني عدوى
+
+196
+00:16:12,990 --> 00:16:17,270
+مضيبة لللبسينيا وهذا بتعمل Dendritic Ulcer اللى
+
+197
+00:16:17,270 --> 00:16:20,410
+شوفناه احنا الان هدف الصحيح هذا اسمه Dendritic
+
+198
+00:16:20,410 --> 00:16:24,070
+Ulcer القرحة السجارية وهذه المميزة بتتكسف
+
+199
+00:16:24,070 --> 00:16:29,850
+بليفروسين طب إذا لم تعالج هذه أو تأخرت اساس
+
+200
+00:16:29,850 --> 00:16:33,930
+والعلاج بتخش ع ال trauma و بتبدأ تحطم ال trauma
+
+201
+00:16:33,930 --> 00:16:38,570
+وتعمل Obesity Obesification Obesification هي تعتيب
+
+202
+00:16:38,570 --> 00:16:45,750
+للقرنيةوالـ Disk Form Stoma اللي هو Obesity وهذا
+
+203
+00:16:45,750 --> 00:16:49,050
+طبعا ناتج عن الـ Antigen Antibody يعني في معركة
+
+204
+00:16:49,050 --> 00:16:55,770
+بين خلايا الليمفيا و بين الفيروس بنتج عنها Antigen
+
+205
+00:16:55,770 --> 00:17:00,070
+Antibody Complement وهذا الكمبلمنت بترسّب في
+
+206
+00:17:00,070 --> 00:17:05,430
+الـStoma وبيعمللي Obesification طب الاندوثيلياملو
+
+207
+00:17:05,430 --> 00:17:08,510
+كان الإنسان ضعيف والقانونية عندي ضعيفة وانهزمت
+
+208
+00:17:08,510 --> 00:17:12,910
+تدخل على الاندوثيليام آخر طبقة داخل القانونية تسمى
+
+209
+00:17:12,910 --> 00:17:17,630
+الاندوثيليايتس تبدأ بخلايا الاندوثيليام وهذا خطير
+
+210
+00:17:17,630 --> 00:17:28,630
+جدا لأن الاندوثيليام يمنع التكوين السائل في طبقات
+
+211
+00:17:28,630 --> 00:17:35,860
+القانونيةاللي بيعمل ال bombing out mechanism يعني
+
+212
+00:17:35,860 --> 00:17:39,700
+بيطرد هو ال aqueous من القرنية إلى الخلف في ال
+
+213
+00:17:39,700 --> 00:17:44,180
+antero chamber فلما يصير endotheliitis يعني بيعجز
+
+214
+00:17:44,180 --> 00:17:49,180
+اللي بيصير قرنية بيك وبتصير تبت ومليانة بيك
+
+215
+00:17:49,180 --> 00:17:53,380
+بالسوائل بقول
+
+216
+00:17:53,380 --> 00:17:56,780
+ان هذا غالبا اللي بيعمله النوع الاول هلبس syntax
+
+217
+00:17:56,780 --> 00:18:04,280
+one اهوقدرت الفيروس الجينية يعني الفيروس مرات
+
+218
+00:18:04,280 --> 00:18:08,140
+بيكون قوي جدا وعدده كبير يخترق الى ذات العين
+
+219
+00:18:08,140 --> 00:18:12,640
+الاندوثالياتس ومرات بيكون القوي مناعيا اللى هو
+
+220
+00:18:12,640 --> 00:18:17,020
+المريض وبتعارج بدري بيجا find النوع الأول في
+
+221
+00:18:17,020 --> 00:18:20,360
+الابسيدا مابدخلش لاعستروما ولا بدخل على
+
+222
+00:18:20,360 --> 00:18:27,220
+الاندوثيريام high disc form اللى هو اندوثالياتس
+
+223
+00:18:27,880 --> 00:18:31,020
+شايفين و مبين في اسم الإسلام كيف لكن هذا هيعمل
+
+224
+00:18:31,020 --> 00:18:37,200
+اعتامة ومش هيخل الواحد يشوف يعني لبصاري كويس طيب
+
+225
+00:18:37,200 --> 00:18:41,800
+لو قلنا إنسان كان ضعيف بصيبه اللي هو إيه إيش
+
+226
+00:18:41,800 --> 00:18:46,760
+ايرايتس herpes simplex airitis يعني انتهاب قزحية
+
+227
+00:18:46,760 --> 00:18:52,340
+الفيروسي نوعين granulomatous و non granulomatous
+
+228
+00:18:52,340 --> 00:18:57,460
+من granuloma لو ترسبفي اللي هو خلايا الدم البيضاء
+
+229
+00:18:57,460 --> 00:19:02,440
+على الاندوثيليام من الخلف ثم ال keratic presbytes
+
+230
+00:19:02,440 --> 00:19:08,100
+presbytes يعني خلايا مترسبة على الاندوثيليام بتاع
+
+231
+00:19:08,100 --> 00:19:11,100
+القنانية وده انا فى الستة سنة بحن بريكوا معاها
+
+232
+00:19:11,100 --> 00:19:17,020
+الآن وممكن تترسب كمان على ال ال iris في ال body
+
+233
+00:19:17,020 --> 00:19:23,980
+وعلى الترابيكولامشورك تما ترابكيولايتس كمانفإذا
+
+234
+00:19:23,980 --> 00:19:26,980
+كان عمل رابيكولايتس في الـ Angle of anterior
+
+235
+00:19:26,980 --> 00:19:30,480
+chamber ممكن ترفع ضبط العين و تعمل بلوكوما و تصبح
+
+236
+00:19:30,480 --> 00:19:35,080
+Intraocular Fissure يبقى هذه الصورة هيها هذه اسمها
+
+237
+00:19:35,080 --> 00:19:39,260
+Granulomatous ليش؟ لأنه في الخلايا هذه الخلف
+
+238
+00:19:39,260 --> 00:19:43,140
+البيضة هذه خلف الاندوكليام اسمها Granulomatous
+
+239
+00:19:43,140 --> 00:19:47,480
+هيها خلف القرنية نشوفها احنا بيضاء لونه كبيرة في
+
+240
+00:19:47,480 --> 00:19:52,930
+الحجم طيب النوع التاني Non-granulomatousهذه ليست
+
+241
+00:19:52,930 --> 00:19:57,610
+كراتك برس بطيطس بدون كراتك برس بطيطس على
+
+242
+00:19:57,610 --> 00:20:01,010
+الاندوهاليوم وغالبا هذا يحدث في الاندوهاليوم
+
+243
+00:20:01,010 --> 00:20:09,050
+الاندوهاليوم اللي هو الضائفين مناعيا فبتلاقي فيهم
+
+244
+00:20:09,050 --> 00:20:16,950
+حمرة ومؤلمة وفيه دمع كتير من الريدو سايكليتس وفيه
+
+245
+00:20:16,950 --> 00:20:20,940
+black vision مش هبشي كويسو فيه myosis ال myosis
+
+246
+00:20:20,940 --> 00:20:26,640
+النتيجة ان السلري muscle صيلها تسمب بالهو الفيروس
+
+247
+00:20:26,640 --> 00:20:33,940
+عند myosis حماية العين تلاقي في pin hole pupil pin
+
+248
+00:20:33,940 --> 00:20:39,640
+hole pupil cells and flair موجودين في الاخره المر
+
+249
+00:20:39,640 --> 00:20:48,800
+وفي يعني زي خلايا عاملة نوع من التعكيروهنا ممكن
+
+250
+00:20:48,800 --> 00:20:56,120
+تعمل هيبوبيون مثل صديد يعني هيبوبيون وين هيبوبيون
+
+251
+00:20:56,120 --> 00:21:01,700
+فيه هيبوبيون بتكون عامل صديد هيه هذا الأبيض
+
+252
+00:21:01,700 --> 00:21:08,500
+هيبوبيون يبقى انه لو كان المريض يعني شيخ كبير و
+
+253
+00:21:08,850 --> 00:21:13,870
+ومنعيا مش كويس بيعملوا نوع هداناني جرانيوميتاس
+
+254
+00:21:13,870 --> 00:21:16,970
+وهاكوبيون يعني كان قوي منعيا بس بيعملوا
+
+255
+00:21:16,970 --> 00:21:23,890
+جرانيوميتاس وشفاء اكتر طيب لو انسان ضعيف اكتر زي
+
+256
+00:21:23,890 --> 00:21:26,870
+مرضى ال aids بيعملوا ريتانايتس herpes syndex
+
+257
+00:21:26,870 --> 00:21:31,170
+retinitis يعني وصل الاشتباكية في ال
+
+258
+00:21:31,170 --> 00:21:36,160
+immunosuppressed بيروح على الشباكية invadeيعني
+
+259
+00:21:36,160 --> 00:21:41,340
+يجزوا الشبكية directly بسرعة وبيعمل كورودايتس
+
+260
+00:21:41,340 --> 00:21:45,520
+وليتانايتس كورودايتس وليتانايتس وبيترايتس التهاب
+
+261
+00:21:45,520 --> 00:21:54,100
+اللي هو السائل الزجاجي وممكن اللي هو يصيب اللي هو
+
+262
+00:21:54,100 --> 00:21:58,800
+الشرعين بتاعة الشبكية ممكن يعمل في الشبكية
+
+263
+00:21:58,800 --> 00:22:04,390
+hemorrhageهو الـ hemorrhage هذا لما يشف اللى هو
+
+264
+00:22:04,390 --> 00:22:08,410
+الدم فع الشباكية بيبقى مكان ال scar يعني يعمل
+
+265
+00:22:08,410 --> 00:22:13,330
+تلايف ويعمل أطر فكرتنا أطر فكرتنا يعني أن الشباكية
+
+266
+00:22:13,330 --> 00:22:20,230
+تصير إيش متلايفة المهم طبعا هذا بيعتمد على النواحي
+
+267
+00:22:20,230 --> 00:22:27,710
+المنعية عند الإنسان طيب نرجع لأدتنا أخطر طبعا شيء
+
+268
+00:22:27,710 --> 00:22:29,050
+أنه يسيبها ال hips
+
+269
+00:22:31,960 --> 00:22:39,440
+بقول لي ال retinitis هاني نوعين congenital و أبطل
+
+270
+00:22:39,440 --> 00:22:45,000
+congenital يعني لحديث الولادة حديث الولادة أثناء
+
+271
+00:22:45,000 --> 00:22:50,100
+نزوره في قناة الولادة خاصة أنف الرحم اللى مصاب
+
+272
+00:22:50,100 --> 00:22:54,080
+بالأنسة الحامل help subjects to وقلنا هذا help
+
+273
+00:22:54,080 --> 00:22:57,900
+subjects to بنزل براسه ويعني بياخدوا ال virus
+
+274
+00:22:57,900 --> 00:23:03,100
+during delivery أثناء الوضعالولادة يعني و هذا
+
+275
+00:23:03,100 --> 00:23:07,040
+بياخده في عينيه و بيصيبه بيكون ضعيف ممكن يصيبه
+
+276
+00:23:07,040 --> 00:23:14,000
+keratitis و encyclitis و يصيبه ايش في عينيه يبقى
+
+277
+00:23:14,000 --> 00:23:18,180
+اسمه neonatal keratitis neonatal الحديثي للولادة
+
+278
+00:23:18,180 --> 00:23:23,040
+التهاب الشبكي حديثي الولادة الفيروسي هذا هذا اللي
+
+279
+00:23:23,040 --> 00:23:27,240
+بيعمل ال tone لأن الأم صابع في أعضاها التناثرية
+
+280
+00:23:27,240 --> 00:23:30,160
+خاصة في الرحمة و المهبل طيب
+
+281
+00:23:33,080 --> 00:23:36,800
+أما اللي بصيب ال adults غالبا هربس ال next one
+
+282
+00:23:36,800 --> 00:23:44,540
+يعني من واحد لواحد من عين لعين يعني خاصة ان واحد
+
+283
+00:23:44,540 --> 00:23:49,940
+حك عينه و سلم على واحد حك عينه هذا اللي سلم عليه
+
+284
+00:23:49,940 --> 00:23:55,000
+صابه في الشبكة بتاعه فالناس اللي ضعيفين منعيا
+
+285
+00:23:55,000 --> 00:23:59,380
+immunosuppressLatinitis is rapidly progressive
+
+286
+00:23:59,380 --> 00:24:03,020
+يعني تتقدم بسرعة في عينيه تنتهي بيلاترال انفكشن في
+
+287
+00:24:03,020 --> 00:24:07,300
+عينيه تنتين وممكن حتى تظهر انكفالايتس fatal
+
+288
+00:24:07,300 --> 00:24:10,540
+encephalitis لأن الشبكية تمشي الفيروس مع العصب
+
+289
+00:24:10,540 --> 00:24:14,800
+البصري of تكناب ويروح على المخ وممكن يعمل fatal
+
+290
+00:24:14,800 --> 00:24:21,360
+encephalitis يعني الجهاب اللي هو المخ المميت طيب
+
+291
+00:24:21,360 --> 00:24:25,540
+ايش اللي عنده Latinitis بيشكي بدينا ايش علاله ايش
+
+292
+00:24:25,540 --> 00:24:29,350
+علاماته يا ربيعلمات و أعراض الـ clinical picture
+
+293
+00:24:29,350 --> 00:24:35,750
+blood pressure في الأول يعني مغبش بعدين نفحص
+
+294
+00:24:35,750 --> 00:24:40,510
+أسلتنا بنلاقي اللي هو الانتيروي سيجمنت فيها
+
+295
+00:24:40,510 --> 00:24:45,130
+inflammation ال inflammation هذا جاي من الريدو
+
+296
+00:24:45,130 --> 00:24:49,270
+سايكليتس والسيريدس فازم الريدو سايكليتس او ال
+
+297
+00:24:49,270 --> 00:24:54,660
+ايريتس يعني وصل القذحية ال فيروسممكن ان يظهر
+
+298
+00:24:54,660 --> 00:24:58,740
+الشبكية ونصر الشبكية ونشوف الشبكية حال دا جهها
+
+299
+00:24:58,740 --> 00:25:04,740
+إيديمة متورمة متفيخة وفي عليها hemorrhage يعني
+
+300
+00:25:04,740 --> 00:25:09,800
+عليها دم وممكن و نغلق الشرايين
+
+301
+00:25:14,820 --> 00:25:18,880
+بعدين نفحص على ال retina بيجينا ايرايتس وبعدين
+
+302
+00:25:18,880 --> 00:25:24,880
+نوسع ال pupil ونعمل retina يعني فحص لجناها
+
+303
+00:25:24,880 --> 00:25:28,500
+الهيموتاس الهيمة وفيها الهيموتاس الهيموتاس
+
+304
+00:25:28,500 --> 00:25:29,560
+الهيموتاس الهيموتاس الهيموتاس الهيموتاس الهيموتاس
+
+305
+00:25:29,560 --> 00:25:30,400
+الهيموتاس الهيموتاس الهيموتاس الهيموتاس الهيموتاس
+
+306
+00:25:30,400 --> 00:25:30,600
+الهيموتاس الهيموتاس الهيموتاس الهيموتاس الهيموتاس
+
+307
+00:25:30,600 --> 00:25:33,100
+الهيموتس الهيموتس الهيموتس الهيموتس الهيموتس
+
+308
+00:25:33,100 --> 00:25:38,240
+الهيموتس الهيموتس الهيموتس الهيموتس الهيموتس
+
+309
+00:25:38,240 --> 00:25:43,110
+الهيموتس الهيمأه symptoms and signs هذي clinical
+
+310
+00:25:43,110 --> 00:25:47,970
+ال diagnoses المخبري لل herpes simplex virus طبعا
+
+311
+00:25:47,970 --> 00:25:53,890
+الا ما نحك بطنه و نحك شفاته او شفايفه هو يعمل
+
+312
+00:25:53,890 --> 00:25:59,590
+viral culture في المزارع الفيروسية مزارع الفيروسية
+
+313
+00:25:59,590 --> 00:26:04,710
+هذا مش عليكم وهذا مش عليكم بس بتقوليلي ايه في
+
+314
+00:26:04,710 --> 00:26:11,470
+viral culture طيبيعني انا شايف انه احنا هيك بلغنا
+
+315
+00:26:11,470 --> 00:26:15,470
+نهاية هذا البروز herpes simplex 1 و2 واسأل الله
+
+316
+00:26:15,470 --> 00:26:20,830
+سبحانه وتعالى انه يعني ينفع يعني بهذه المحاضرة لأن
+
+317
+00:26:20,830 --> 00:26:25,510
+هذا أكتر شيء بيصيب القرانية ال herpes simplex
+
+318
+00:26:25,510 --> 00:26:29,310
+تحياتي لكوا في نهاية المحاضرة التلاتين يعني فضلنا
+
+319
+00:26:29,310 --> 00:26:33,510
+حوالي محاضرة او تلاتة و بنخلص بالسلامة ان شاء الله
+
+320
+00:26:33,510 --> 00:26:34,490
+السلام عليكم
+
diff --git a/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/MQ4RtaEQjtc_raw.json b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/MQ4RtaEQjtc_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..c10fd2bfec6cc6fab12212c457dcd4eebc23d46c
--- /dev/null
+++ b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/MQ4RtaEQjtc_raw.json
@@ -0,0 +1 @@
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"probability": 0.7145182291666666}, {"start": 837.3, "end": 837.62, "word": " يعني", "probability": 0.830322265625}, {"start": 837.62, "end": 838.74, "word": " ونلاقي", "probability": 0.7783203125}, {"start": 838.74, "end": 839.52, "word": " كام", "probability": 0.90625}, {"start": 839.52, "end": 840.3, "word": " كبير", "probability": 0.9899088541666666}, {"start": 840.3, "end": 840.62, "word": " من", "probability": 0.9921875}, {"start": 840.62, "end": 841.44, "word": " الخلايا", "probability": 0.9475911458333334}, {"start": 841.44, "end": 842.22, "word": " البارعة", "probability": 0.8072916666666666}, {"start": 842.22, "end": 843.46, "word": " البيضاء", "probability": 0.875732421875}, {"start": 843.46, "end": 844.4, "word": " في", "probability": 0.939453125}, {"start": 844.4, "end": 845.48, "word": " قاع", "probability": 0.853759765625}, {"start": 845.48, "end": 848.18, "word": " القلصة", "probability": 0.62213134765625}, {"start": 848.18, "end": 849.58, "word": " طيب", "probability": 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"end": 855.37, "word": "هيلهظ", "probability": 0.64111328125}, {"start": 855.37, "end": 855.61, "word": " ان", "probability": 0.78369140625}, {"start": 855.61, "end": 856.17, "word": " استرومة", "probability": 0.5991668701171875}, {"start": 856.17, "end": 856.37, "word": " بعد", "probability": 0.6884765625}, {"start": 856.37, "end": 856.69, "word": " اكثر", "probability": 0.5601603190104166}, {"start": 856.69, "end": 856.99, "word": " فيها", "probability": 0.876708984375}, {"start": 856.99, "end": 857.73, "word": " نكروزيز", "probability": 0.7237141927083334}, {"start": 857.73, "end": 858.39, "word": " ذوبان", "probability": 0.7535807291666666}, {"start": 858.39, "end": 860.49, "word": " في", "probability": 0.5048828125}, {"start": 860.49, "end": 861.19, "word": " استرومة", "probability": 0.9678955078125}, {"start": 861.19, "end": 862.63, "word": " وهذا", "probability": 0.948974609375}, {"start": 862.63, "end": 863.15, "word": " خطير", "probability": 0.97900390625}, {"start": 863.15, 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"probability": 0.92822265625}, {"start": 877.36, "end": 878.12, "word": " فاللي", "probability": 0.3201497395833333}, {"start": 878.12, "end": 878.42, "word": " جيها", "probability": 0.7692057291666666}, {"start": 878.42, "end": 878.86, "word": " 100", "probability": 0.76806640625}, {"start": 878.86, "end": 879.4, "word": " او", "probability": 0.892822265625}, {"start": 879.4, "end": 879.74, "word": " 200", "probability": 0.9443359375}, {"start": 879.74, "end": 880.78, "word": " تقريبا", "probability": 0.9900390625}, {"start": 880.78, "end": 881.5, "word": " بيقول", "probability": 0.74462890625}, {"start": 881.5, "end": 881.84, "word": " ان", "probability": 0.95556640625}, {"start": 881.84, "end": 883.58, "word": " الكل", "probability": 0.344970703125}, {"start": 883.58, "end": 884.02, "word": " جين", "probability": 0.5986328125}, {"start": 884.02, "end": 884.84, "word": " bundles", "probability": 0.6868896484375}, {"start": 884.84, "end": 885.28, "word": " بتاعة", "probability": 0.9158528645833334}, {"start": 885.28, "end": 885.98, "word": " stroma", "probability": 0.710205078125}, {"start": 885.98, "end": 887.16, "word": " اه", "probability": 0.57171630859375}, {"start": 887.16, "end": 887.58, "word": " بدت", "probability": 0.95654296875}, {"start": 887.58, "end": 887.78, "word": " ان", "probability": 0.921875}, {"start": 887.78, "end": 888.42, "word": " هي", "probability": 0.732421875}, {"start": 888.42, "end": 890.64, "word": " تتحلل", "probability": 0.9380859375}], "temperature": 1.0}, {"id": 37, "seek": 91158, "start": 892.2, "end": 911.58, "text": "في نفس الوقت dismiss membrane وهو الطبقة الرابعة في القرنية يعني أول طبقة Epithelium ثاني طبقة Bowens membrane ثالث طبقة Stroma رابع طبقة dismiss membrane آخر طبقة داخلها اسمها Endothelium", "tokens": [41185, 8717, 36178, 2423, 30543, 2655, 16974, 19651, 37037, 2407, 41950, 3555, 28671, 34892, 16758, 27884, 8978, 25062, 2288, 1863, 10632, 37495, 22653, 5551, 12610, 23032, 3555, 28671, 9970, 355, 338, 2197, 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الرابعة", "probability": 0.97021484375}, {"start": 898.94, "end": 899.26, "word": " في", "probability": 0.83935546875}, {"start": 899.26, "end": 899.92, "word": " القرنية", "probability": 0.8411865234375}, {"start": 899.92, "end": 900.7, "word": " يعني", "probability": 0.7822265625}, {"start": 900.7, "end": 900.94, "word": " أول", "probability": 0.864990234375}, {"start": 900.94, "end": 901.24, "word": " طبقة", "probability": 0.984375}, {"start": 901.24, "end": 901.9, "word": " Epithelium", "probability": 0.79254150390625}, {"start": 901.9, "end": 903.32, "word": " ثاني", "probability": 0.7529296875}, {"start": 903.32, "end": 903.66, "word": " طبقة", "probability": 0.9879557291666666}, {"start": 903.66, "end": 904.06, "word": " Bowens", "probability": 0.40771484375}, {"start": 904.06, "end": 904.66, "word": " membrane", "probability": 0.70654296875}, {"start": 904.66, "end": 905.14, "word": " ثالث", "probability": 0.7845052083333334}, {"start": 905.14, "end": 905.42, "word": " طبقة", 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اقوى الطبقات في القرنية انه يعني بيقاوم ال infection ومرور البكتيريا يعني هو هيكون هنا تقريبا ورستروما dismembrane ومنه جوا طبقة ال endothelium فهو هذا بيقاوم ال dismembrane يعني بقدر امكان بقاوم ال enzymatic البكتيريا", "tokens": [6027, 5016, 38436, 28671, 16472, 3224, 38637, 3555, 2655, 16472, 2423, 12456, 443, 1443, 1929, 9154, 1975, 4587, 2407, 7578, 41950, 3555, 4587, 9307, 8978, 25062, 2288, 1863, 10632, 16472, 3224, 37495, 22653, 4724, 1829, 4587, 995, 20498, 2423, 11764, 4032, 29973, 13063, 29739, 4117, 2655, 13546, 25528, 37495, 22653, 31439, 39896, 30544, 34105, 6055, 4587, 16572, 3555, 995, 4032, 2288, 14851, 2288, 20498, 995, 12456, 443, 1443, 1929, 4032, 27842, 3224, 10874, 14407, 23032, 3555, 28671, 2423, 917, 900, 338, 2197, 6156, 3224, 2407, 23758, 4724, 1829, 4587, 995, 20498, 2423, 12456, 443, 1443, 1929, 37495, 22653, 4724, 28543, 2288, 1975, 2304, 41361, 4724, 4587, 995, 20498, 2423, 16272, 25915, 29739, 4117, 2655, 13546, 25528], "avg_logprob": 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{"start": 918.06, "end": 918.66, "word": " انه", "probability": 0.9208984375}, {"start": 918.66, "end": 919.08, "word": " يعني", "probability": 0.91162109375}, {"start": 919.08, "end": 919.92, "word": " بيقاوم", "probability": 0.946484375}, {"start": 919.92, "end": 920.1, "word": " ال", "probability": 0.95166015625}, {"start": 920.1, "end": 920.56, "word": " infection", "probability": 0.77099609375}, {"start": 920.56, "end": 921.08, "word": " ومرور", "probability": 0.9114583333333334}, {"start": 921.08, "end": 921.92, "word": " البكتيريا", "probability": 0.9275390625}, {"start": 921.92, "end": 922.78, "word": " يعني", "probability": 0.8408203125}, {"start": 922.78, "end": 922.94, "word": " هو", "probability": 0.7177734375}, {"start": 922.94, "end": 923.32, "word": " هيكون", "probability": 0.820556640625}, {"start": 923.32, "end": 923.56, "word": " هنا", "probability": 0.595703125}, {"start": 923.56, "end": 924.02, "word": " تقريبا", "probability": 0.952734375}, {"start": 924.02, "end": 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رجيخ", "probability": 0.8055419921875}, {"start": 949.89, "end": 950.17, "word": " جدا", "probability": 0.983154296875}, {"start": 950.17, "end": 950.55, "word": " يعني", "probability": 0.8154296875}, {"start": 950.55, "end": 952.77, "word": " طيب", "probability": 0.9630533854166666}, {"start": 952.77, "end": 954.89, "word": " هلاحظ", "probability": 0.78369140625}, {"start": 954.89, "end": 955.27, "word": " انه", "probability": 0.8447265625}, {"start": 955.27, "end": 955.37, "word": " لو", "probability": 0.9814453125}, {"start": 955.37, "end": 955.99, "word": " طلعنا", "probability": 0.984375}, {"start": 955.99, "end": 956.75, "word": " بستخلام", "probability": 0.653466796875}], "temperature": 1.0}, {"id": 40, "seek": 98328, "start": 957.42, "end": 983.28, "text": "في الـ anterior chamber هنلاقي فيها reaction خلايا التهابية يعني خلايا التهابية وبالتالي reaction هذا عمل Trabeculitis أي Trabecula مشورك اللي في ال angle of anterior chamber هنلاقي اللي فيه Trabeculitis التهاب في Trabecula مشورك ولاحظ فيه ايريتس اللي هو القزحية الملتهبة", "tokens": [41185, 2423, 39184, 22272, 13610, 8032, 1863, 15040, 38436, 8978, 11296, 5480, 16490, 15040, 25528, 16712, 3224, 16758, 10632, 37495, 22653, 16490, 15040, 25528, 16712, 3224, 16758, 10632, 46599, 6027, 2655, 6027, 1829, 5480, 23758, 6225, 42213, 5403, 650, 2444, 16074, 36632, 5403, 650, 2444, 64, 37893, 13063, 4117, 13672, 1829, 8978, 2423, 5802, 295, 22272, 13610, 8032, 1863, 15040, 38436, 13672, 1829, 8978, 3224, 5403, 650, 2444, 16074, 16712, 3224, 16758, 8978, 5403, 650, 2444, 64, 37893, 13063, 4117, 4032, 15040, 5016, 19913, 8978, 3224, 1975, 13546, 36081, 3794, 13672, 1829, 31439, 25062, 11622, 5016, 10632, 9673, 1211, 47395, 49401], "avg_logprob": -0.3053002509416318, "compression_ratio": 2.00990099009901, "no_speech_prob": 0.0, "words": [{"start": 957.42, "end": 957.76, "word": "في", "probability": 0.69287109375}, {"start": 957.76, "end": 957.86, "word": " الـ", "probability": 0.34417724609375}, {"start": 957.86, 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"end": 965.86, "word": " هذا", "probability": 0.56298828125}, {"start": 965.86, "end": 966.08, "word": " عمل", "probability": 0.746826171875}, {"start": 966.08, "end": 967.1, "word": " Trabeculitis", "probability": 0.63714599609375}, {"start": 967.1, "end": 968.28, "word": " أي", "probability": 0.53271484375}, {"start": 968.28, "end": 968.86, "word": " Trabecula", "probability": 0.581756591796875}, {"start": 968.86, "end": 969.4, "word": " مشورك", "probability": 0.8567708333333334}, {"start": 969.4, "end": 969.58, "word": " اللي", "probability": 0.7529296875}, {"start": 969.58, "end": 969.72, "word": " في", "probability": 0.9404296875}, {"start": 969.72, "end": 969.96, "word": " ال", "probability": 0.5224609375}, {"start": 969.96, "end": 970.4, "word": " angle", "probability": 0.428955078125}, {"start": 970.4, "end": 970.82, "word": " of", "probability": 0.9208984375}, {"start": 970.82, "end": 971.34, "word": " anterior", "probability": 0.7255859375}, {"start": 971.34, "end": 972.04, 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{"id": 42, "seek": 104031, "start": 1012.85, "end": 1040.31, "text": "هنا فيه اللي هو Elsa يعني ممكن جدا هاي شايفين يعني هاي اللي هو انا صبغت fluorescein و بعدين اعطاني لون بني او ذهبي اه بقول هذا كونه ال Elsa يعني انه اول اشي ان ال epithelium في detect", "tokens": [3224, 8315, 8978, 3224, 13672, 1829, 31439, 36342, 37495, 22653, 3714, 43020, 10874, 28259, 8032, 47302, 13412, 995, 33911, 9957, 37495, 22653, 8032, 47302, 13672, 1829, 31439, 1975, 8315, 20328, 3555, 17082, 2655, 32471, 384, 259, 4032, 39182, 9957, 1975, 3615, 9566, 7649, 1829, 5296, 11536, 4724, 22653, 1975, 2407, 29910, 3224, 21292, 1975, 3224, 4724, 39648, 23758, 9122, 11536, 3224, 2423, 36342, 37495, 22653, 16472, 3224, 1975, 12610, 1975, 8592, 1829, 16472, 2423, 2388, 355, 338, 2197, 8978, 5531], "avg_logprob": -0.3258101734114282, "compression_ratio": 1.646067415730337, "no_speech_prob": 0.0, "words": [{"start": 1012.85, "end": 1013.31, "word": "هنا", "probability": 0.708251953125}, {"start": 1013.31, "end": 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diff --git a/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/NRAD-Paf02Q_raw.json b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/NRAD-Paf02Q_raw.json
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index 0000000000000000000000000000000000000000..fd0e7fa551e5bc0086772a56973b69d48cd4058b
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@@ -0,0 +1 @@
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{"start": 921.44, "end": 922.16, "word": " دخلت", "probability": 0.9388427734375}, {"start": 922.16, "end": 922.7, "word": " في", "probability": 0.93994140625}, {"start": 922.7, "end": 923.26, "word": " أمعاه", "probability": 0.89697265625}, {"start": 923.26, "end": 924.42, "word": " طلعها", "probability": 0.72930908203125}, {"start": 924.42, "end": 924.58, "word": " في", "probability": 0.95458984375}, {"start": 924.58, "end": 925.2, "word": " البراز", "probability": 0.7254231770833334}, {"start": 925.2, "end": 926.68, "word": " أه", "probability": 0.55029296875}, {"start": 926.68, "end": 926.96, "word": " عشان", "probability": 0.8828125}, {"start": 926.96, "end": 927.46, "word": " يهدغل", "probability": 0.545703125}], "temperature": 1.0}, {"id": 39, "seek": 95571, "start": 928.83, "end": 955.71, "text": "هي الإنسان فيه أخد ال cyst في طعامه و شرابه و بعدين هذا ال cyst جوه بيصير trophozoite بتعمل له مرض لو بده يطلع هبطلع على ال cyst و ال cyst هادي يعني هذا الصورة بتاعة ال trophozoite 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"end": 946.05, "word": " trophozoite", "probability": 0.82452392578125}, {"start": 946.05, "end": 946.79, "word": " كيف", "probability": 0.90283203125}, {"start": 946.79, "end": 947.15, "word": " هي", "probability": 0.499755859375}, {"start": 947.15, "end": 947.39, "word": " ال", "probability": 0.8935546875}, {"start": 947.39, "end": 948.03, "word": " nucleus", "probability": 0.9072265625}, {"start": 948.03, "end": 949.61, "word": " ويله", "probability": 0.6680501302083334}, {"start": 949.61, "end": 950.31, "word": " انتبلازم", "probability": 0.5823160807291666}, {"start": 950.31, "end": 951.21, "word": " كرتيوكيولام", "probability": 0.627777099609375}, {"start": 951.21, "end": 952.05, "word": " راقع", "probability": 0.77947998046875}, {"start": 952.05, "end": 952.95, "word": " ويله", "probability": 0.9365234375}, {"start": 952.95, "end": 953.71, "word": " mitochondria", "probability": 0.9208984375}, {"start": 953.71, "end": 954.17, "word": " و", "probability": 0.60009765625}, {"start": 954.17, "end": 954.49, "word": " هذه", "probability": 0.23828125}, {"start": 954.49, "end": 955.27, "word": " مصانع", "probability": 0.71893310546875}, {"start": 955.27, "end": 955.71, "word": " الطاقة", "probability": 0.9685872395833334}], "temperature": 1.0}, {"id": 40, "seek": 97467, "start": 956.27, "end": 974.67, "text": "هي الموتوكولدريا زي و زي خريط الإنسان هذي اللي برا اسمها capsule اللي برا هذي اسمها capsule و هذي ال cell wall هذي ال cell wall الخضرة cell wall وهي في ريبوزومز مخانة لبروتينات", "tokens": [3224, 1829, 9673, 35473, 2407, 4117, 12610, 3215, 2288, 25528, 30767, 1829, 4032, 30767, 1829, 16490, 16572, 9566, 33688, 1863, 3794, 7649, 8032, 8848, 1829, 13672, 1829, 4724, 23557, 24525, 2304, 11296, 29247, 13672, 1829, 4724, 23557, 8032, 8848, 1829, 24525, 2304, 11296, 29247, 4032, 8032, 8848, 1829, 2423, 2815, 2929, 8032, 8848, 1829, 2423, 2815, 2929, 33962, 11242, 25720, 2815, 2929, 37037, 1829, 8978, 12602, 1829, 3555, 2407, 11622, 20498, 11622, 3714, 9778, 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"end": 962.23, "word": " اسمها", "probability": 0.9786783854166666}, {"start": 962.23, "end": 962.65, "word": " capsule", "probability": 0.84130859375}, {"start": 962.65, "end": 963.43, "word": " اللي", "probability": 0.6566162109375}, {"start": 963.43, "end": 963.69, "word": " برا", "probability": 0.98583984375}, {"start": 963.69, "end": 964.11, "word": " هذي", "probability": 0.7938639322916666}, {"start": 964.11, "end": 965.01, "word": " اسمها", "probability": 0.9431966145833334}, {"start": 965.01, "end": 965.31, "word": " capsule", "probability": 0.492919921875}, {"start": 965.31, "end": 966.25, "word": " و", "probability": 0.468017578125}, {"start": 966.25, "end": 966.59, "word": " هذي", "probability": 0.8387044270833334}, {"start": 966.59, "end": 966.77, "word": " ال", "probability": 0.458740234375}, {"start": 966.77, "end": 966.99, "word": " cell", "probability": 0.89306640625}, {"start": 966.99, "end": 967.41, "word": " wall", "probability": 0.90478515625}, {"start": 967.41, "end": 968.69, "word": " هذي", "probability": 0.6916097005208334}, {"start": 968.69, "end": 968.77, "word": " ال", "probability": 0.822265625}, {"start": 968.77, "end": 968.95, "word": " cell", "probability": 0.9658203125}, {"start": 968.95, "end": 969.27, "word": " wall", "probability": 0.90478515625}, {"start": 969.27, "end": 969.87, "word": " الخضرة", "probability": 0.8116861979166666}, {"start": 969.87, "end": 970.71, "word": " cell", "probability": 0.61083984375}, {"start": 970.71, "end": 971.45, "word": " wall", "probability": 0.86669921875}, {"start": 971.45, "end": 972.17, "word": " وهي", "probability": 0.707275390625}, {"start": 972.17, "end": 972.43, "word": " في", "probability": 0.9521484375}, {"start": 972.43, "end": 973.39, "word": " ريبوزومز", "probability": 0.7894461495535714}, {"start": 973.39, "end": 973.91, "word": " مخانة", "probability": 0.83935546875}, {"start": 973.91, "end": 974.67, "word": " لبروتينات", "probability": 0.86826171875}], "temperature": 1.0}, {"id": 41, "seek": 99569, "start": 975.19, "end": 995.69, "text": "وهي ال nucleus يبقى هذه يعني حقيقة متكاملة يعني تشبه خلية الإنسان و أرقى من خلية البكتيريا بكتير طيب ايش المرض اللى بتعمله انت مليه بابا السليفيكا ال atrophoid في حد ذاته هو الطور النشط في قلون القلون الإنسان", "tokens": [2407, 3224, 1829, 2423, 28055, 7251, 3555, 4587, 7578, 29538, 37495, 22653, 11331, 38436, 28671, 44650, 4117, 10943, 37977, 37495, 22653, 6055, 8592, 3555, 3224, 16490, 1211, 10632, 33688, 1863, 3794, 7649, 4032, 5551, 2288, 4587, 7578, 9154, 16490, 1211, 10632, 29739, 4117, 2655, 13546, 25528, 4724, 4117, 2655, 13546, 23032, 1829, 3555, 1975, 1829, 8592, 9673, 43042, 13672, 7578, 39894, 25957, 43761, 16472, 2655, 3714, 20292, 3224, 4724, 16758, 995, 21136, 20292, 5172, 1829, 4117, 995, 2423, 412, 11741, 17079, 8978, 11331, 3215, 29910, 9307, 3224, 31439, 41950, 13063, 28239, 8592, 9566, 8978, 12174, 1211, 11536, 25062, 1211, 11536, 33688, 1863, 3794, 7649], "avg_logprob": -0.2513392925262451, "compression_ratio": 1.7156398104265402, "no_speech_prob": 0.0, "words": [{"start": 975.19, "end": 975.63, "word": "وهي", "probability": 0.6053059895833334}, {"start": 975.63, "end": 975.75, "word": " ال", "probability": 0.60546875}, {"start": 975.75, "end": 976.15, "word": " nucleus", "probability": 0.38232421875}, {"start": 976.15, "end": 976.99, "word": " يبقى", "probability": 0.785400390625}, {"start": 976.99, "end": 977.27, "word": " هذه", "probability": 0.7216796875}, {"start": 977.27, "end": 977.59, "word": " يعني", "probability": 0.66845703125}, {"start": 977.59, "end": 978.51, "word": " حقيقة", "probability": 0.98095703125}, {"start": 978.51, "end": 979.13, "word": " متكاملة", "probability": 0.96533203125}, {"start": 979.13, "end": 979.31, "word": " يعني", "probability": 0.775634765625}, {"start": 979.31, "end": 979.63, "word": " تشبه", "probability": 0.81427001953125}, {"start": 979.63, "end": 979.83, "word": " خلية", "probability": 0.90380859375}, {"start": 979.83, "end": 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" في", "probability": 0.8203125}, {"start": 993.95, "end": 994.45, "word": " قلون", "probability": 0.8185221354166666}, {"start": 994.45, "end": 995.01, "word": " القلون", "probability": 0.8234049479166666}, {"start": 995.01, "end": 995.69, "word": " الإنسان", "probability": 0.9822998046875}], "temperature": 1.0}, {"id": 42, "seek": 102185, "start": 996.33, "end": 1021.85, "text": "و يعني هو بيعمل التعناية اللى بيقولوا عنها amoebic dysentery اللى هو الزحار الأميبي الذحار الأميبي اللى بيكون فيه كثير من المخاط و قليل من الدم احفظ الدينتر كثير من المخاط و قليل من الدم", "tokens": [2407, 37495, 22653, 31439, 4724, 1829, 25957, 1211, 16712, 3615, 8315, 10632, 13672, 7578, 4724, 1829, 39648, 14407, 18871, 11296, 669, 7921, 65, 299, 15243, 14278, 88, 13672, 7578, 31439, 6024, 110, 5016, 9640, 16247, 2304, 1829, 21292, 32545, 5016, 9640, 16247, 2304, 1829, 21292, 13672, 7578, 4724, 1829, 30544, 8978, 3224, 9122, 12984, 13546, 9154, 9673, 9778, 41193, 4032, 12174, 20292, 1211, 9154, 32748, 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أخطر من الأولانية يعني هذه التقرحات في جدار القلون خطيرة جدا ويقولك إذا وصلت الدم ممكن تسرح وتروح على ال blood", "tokens": [3224, 24192, 5551, 3794, 2288, 3615, 13412, 995, 33911, 9957, 23758, 41950, 3555, 9778, 3660, 33962, 41193, 13546, 37037, 15730, 41950, 3555, 9778, 3660, 18863, 11242, 1211, 10632, 13412, 38688, 3224, 7251, 1863, 11622, 1211, 11778, 2304, 6156, 3224, 24192, 5551, 9778, 9566, 2288, 9154, 16247, 12610, 7649, 10632, 37495, 22653, 29538, 16712, 4587, 2288, 5016, 9307, 8978, 10874, 3215, 9640, 25062, 1211, 11536, 16490, 9566, 48923, 10874, 28259, 4032, 1829, 39648, 4117, 11933, 15730, 4032, 36520, 2655, 32748, 2304, 3714, 43020, 6055, 3794, 2288, 5016, 34683, 32887, 5016, 15844, 2423, 3390], "avg_logprob": -0.22160618984571068, "compression_ratio": 1.7446808510638299, "no_speech_prob": 4.172325134277344e-07, "words": [{"start": 1152.97, "end": 1153.43, "word": "هذه", "probability": 0.77099609375}, {"start": 1153.43, "end": 1155.03, "word": " أسرع", "probability": 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"text": "يعني ممكن جدا انه اقل شيء منها تعمل الزحار الاميبي اه والاكثر انها تعمل تفرحات لدار الأمعاء والاكثر انها تروح على الكبد او على الرئة او على المخ والأعضاء الأخرى و تعمل فيها دماغ كيف يتم تشخيص الانتميبة هستيلوتيكا ناخد اللي هو من stool من البناز", "tokens": [40228, 22653, 3714, 43020, 10874, 28259, 16472, 3224, 1975, 4587, 1211, 44049, 38207, 9154, 11296, 6055, 25957, 1211, 6024, 110, 5016, 9640, 2423, 10943, 1829, 21292, 1975, 3224, 16070, 995, 4117, 49115, 16472, 11296, 6055, 25957, 1211, 6055, 5172, 2288, 5016, 9307, 5296, 3215, 9640, 16247, 2304, 3615, 16606, 16070, 995, 4117, 49115, 16472, 11296, 6055, 32887, 5016, 15844, 33251, 44510, 1975, 2407, 15844, 34892, 19986, 3660, 1975, 2407, 15844, 9673, 9778, 16070, 10721, 3615, 11242, 16606, 16247, 34740, 7578, 4032, 6055, 25957, 1211, 8978, 11296, 11778, 2304, 5718, 118, 9122, 33911, 7251, 39237, 6055, 8592, 9778, 1829, 9381, 2423, 7649, 39237, 1829, 49401, 8032, 14851, 26895, 35473, 1829, 4117, 995, 8717, 47283, 3215, 13672, 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new file mode 100644
index 0000000000000000000000000000000000000000..2c276e594dc411d9554fc9cdae735173140cd58a
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@@ -0,0 +1 @@
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"probability": 0.6328125}, {"start": 1473.67, "end": 1473.99, "word": " تشوفوا", "probability": 0.8577880859375}, {"start": 1473.99, "end": 1474.41, "word": " نجاح", "probability": 0.94775390625}, {"start": 1474.41, "end": 1475.01, "word": " الباهر", "probability": 0.955078125}, {"start": 1475.01, "end": 1475.37, "word": " والسلام", "probability": 0.9153645833333334}, {"start": 1475.37, "end": 1475.99, "word": " عليكم", "probability": 0.959228515625}, {"start": 1475.99, "end": 1476.95, "word": " ورحمة", "probability": 0.9844970703125}, {"start": 1476.95, "end": 1477.49, "word": " الله", "probability": 0.9599609375}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1478.693125, "duration_after_vad": 1448.0424999999977}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/UR-KJ3G1UjQ_postprocess.srt b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/UR-KJ3G1UjQ_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..6c0a0a475e7514f6755e7d0f2a76fcda2ef44559
--- /dev/null
+++ b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/UR-KJ3G1UjQ_postprocess.srt
@@ -0,0 +1,980 @@
+1
+00:00:01,280 --> 00:00:04,840
+أعوذ بالله من الشيطان الرجيم بسم الله الرحمن
+
+2
+00:00:04,840 --> 00:00:09,240
+الرحيم الحمد لله وكفا و أصلي و أسلم على النبي
+
+3
+00:00:09,240 --> 00:00:14,380
+المصطفى أعوذ و لايكم في المحاضرة السابعة والعشرين
+
+4
+00:00:14,380 --> 00:00:20,800
+لإكمال Trachoma وهو المرض الذي يسبب العمى في أكتر
+
+5
+00:00:20,800 --> 00:00:24,760
+العالم المختلفة إذا احنا هتكلم الآن على
+
+6
+00:00:24,760 --> 00:00:31,610
+Epidemiology بقول إن نساء بشكل تلت أربع مصابينو
+
+7
+00:00:31,610 --> 00:00:36,330
+أكثر من الرجال في العالم خاصة في المراحل المتأخرة
+
+8
+00:00:36,330 --> 00:00:40,750
+اللي بيأثر فيها blindness و psychiasis و entropion
+
+9
+00:00:40,750 --> 00:00:45,630
+وجدوا أن النساء أكثر لأن النساء أكثر تساقن
+
+10
+00:00:45,630 --> 00:00:52,870
+بالأطفال من ناحية التربية و التمريد كأمهات و
+
+11
+00:00:52,870 --> 00:00:58,690
+حاكمات فبنصابوا أكتر من الرجال يعني أربع العميان
+
+12
+00:00:58,690 --> 00:01:03,280
+بهذا الموضوع من النساءمجموعة الصحة العالمية WHO
+
+13
+00:01:03,280 --> 00:01:10,780
+قدرت ان العميان في العالم من هذا المرض 6 مليون لكن
+
+14
+00:01:10,780 --> 00:01:19,360
+الحقيقة ان في 10 مليون موجودين و ممكن ان يتعالجوا
+
+15
+00:01:19,360 --> 00:01:24,740
+بجرافة و نمنع العم عنهم لكن في 6 مليون في العالم
+
+16
+00:01:24,740 --> 00:01:30,710
+blind blind يعني 6 مليونعميان وفي عشرة مليون لو
+
+17
+00:01:30,710 --> 00:01:38,410
+ماتعالجوش بيصير عميان كمان طيب كيف تنتقل اللي هو
+
+18
+00:01:38,410 --> 00:01:42,830
+العدوى كيف تنتقل العدوى تنتقل عدوى بأربع طرق
+
+19
+00:01:42,830 --> 00:01:49,590
+الطريقة الأولى from eye to eye يعني مثلا الان
+
+20
+00:01:49,590 --> 00:01:55,570
+المرأة بتلاعب ابنها الصغير اه بتفت وجهه في وجهه
+
+21
+00:01:56,220 --> 00:02:00,960
+فسهلة ان البكتيريه تنتقل من العين للعين يعني هذه
+
+22
+00:02:00,960 --> 00:02:08,880
+eye to eye من عين للعين يعني ممكن ان المصاب ففت
+
+23
+00:02:08,880 --> 00:02:14,720
+وجهه في وجهه الصحيح زي يعني الراجل وزوجته زي الطفل
+
+24
+00:02:14,720 --> 00:02:22,430
+و اللي هو الأم او الأب ممكن التانية spliton
+
+25
+00:02:22,430 --> 00:02:26,910
+fingers هذه اكتر ان واحد بيحك في عينه لان عينه
+
+26
+00:02:26,910 --> 00:02:35,230
+فيهم تهيج وبعدين بيسلم على الناس او يعني بيحط ايدي
+
+27
+00:02:35,230 --> 00:02:40,990
+على عين واحد نصاب يبقى ال fingers الأصابع يعني ال
+
+28
+00:02:40,990 --> 00:02:47,200
+fingers يخصل فيها الأصابعالاشي التالت فومايكس
+
+29
+00:02:47,200 --> 00:02:51,660
+فومايكس لأ هذه يعني مناديل العيان ومنابس العيان
+
+30
+00:02:51,660 --> 00:02:58,800
+ويعني الحاجات اللي خاصة طاجية حاجة بلبسها a cloth
+
+31
+00:02:58,800 --> 00:03:04,940
+اللي هو المنابس و الطاجية و الحطة و المناديل و
+
+32
+00:03:04,940 --> 00:03:09,600
+الكلام زي هذا برضه هذا من المريض إلى الصحيح بصيبه
+
+33
+00:03:09,600 --> 00:03:16,690
+الأخر اشي و هو كتير جدا ل fliesseeking flies يعني
+
+34
+00:03:16,690 --> 00:03:21,730
+الذباب المنتشر هذا الذباب المنتشر بيجي على عينين
+
+35
+00:03:21,730 --> 00:03:25,910
+واحد نايم بيحمل غروب على عينين أصحاء بيحط
+
+36
+00:03:25,910 --> 00:03:30,950
+البكتيريا فهذا يعني أكبر عامل أو أوسع عامل في
+
+37
+00:03:30,950 --> 00:03:37,390
+الانتشار اللي هو وجود ذباب في بيئة معينة علشان هي
+
+38
+00:03:37,390 --> 00:03:44,170
+مكافحة ذباب مكافحة لهذا المرضبقول لي عوام الخطر في
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+39
+00:03:44,170 --> 00:03:49,990
+الموضوع تم اكتشافها نحن نتكلم عن عوام الخطر التي
+
+40
+00:03:49,990 --> 00:03:54,250
+تساعد على انتشار هذا المرض بهذه الطرق المختلفة
+
+41
+00:03:54,250 --> 00:03:59,430
+بقول العوام الخطر أهم شي فيه حاجتين ال crowd
+
+42
+00:03:59,430 --> 00:04:05,290
+الزحام و بعدين limited water supply و قلة الميه
+
+43
+00:04:05,290 --> 00:04:10,050
+زحام و قلة الميه يعني مثلا لو تشوف انتوا وخيمة
+
+44
+00:04:10,050 --> 00:04:13,710
+اللاجئين في سوريافي شمال سوريا وخيمات اللاجئين في
+
+45
+00:04:13,710 --> 00:04:18,190
+أفريقيا لو خمت اللاجئين احنا في أغزا هنا كنا قبل
+
+46
+00:04:18,190 --> 00:04:23,470
+ستين سنة كان وضعنا كرب جدا المي كانت جدا قليلا
+
+47
+00:04:23,470 --> 00:04:27,410
+تجيش إلا ساعة في اليوم في تجمعات معينة او ساعتين
+
+48
+00:04:27,410 --> 00:04:32,750
+في اليوم خاصة في المخيمات والناس overcrowding مش
+
+49
+00:04:32,750 --> 00:04:35,970
+crowding overcrowding وحتى الآن هم يقولوا أكتر
+
+50
+00:04:35,970 --> 00:04:41,660
+منطقة مضحمة بالسكان في العالم كتر ليشلأنه بيقولك
+
+51
+00:04:41,660 --> 00:04:46,360
+يعني انه مافي في العالم ان كيلومة مربع بيسوخه خمس
+
+52
+00:04:46,360 --> 00:04:51,680
+ألاف نسمة زي مثلا مخيم الشاطئ زي مخيم جباليا يعني
+
+53
+00:04:51,680 --> 00:04:56,820
+على كل كيلومة مربع خمس ألاف أو ست ألاف أو سبع ألاف
+
+54
+00:04:56,820 --> 00:05:05,060
+نسمة يبقى وين ما فيه crowd وين ما فيه قلة ميه يكون
+
+55
+00:05:05,060 --> 00:05:11,320
+تركومها هذا هو الجوها الجوهالأن الميه اللى بتساعد
+
+56
+00:05:11,320 --> 00:05:16,860
+على نظافة المجهد ونظافة الإيدين وعلى غسيل الملابس
+
+57
+00:05:16,860 --> 00:05:26,280
+وعلى غسيل الأرض الميه مهمة جدا طيب الأم الناشيه
+
+58
+00:05:26,280 --> 00:05:33,420
+تضمن تغسل أولاد إيديهم تغسل وشهم حمّمهم كل شوية
+
+59
+00:05:33,420 --> 00:05:37,600
+فالإفرادات ما تفضلش في عينه يعني في نظافة وين ما
+
+60
+00:05:37,600 --> 00:05:43,890
+في نظافةبقل المرض وين ما فيه قلة نظافة بزيد المرض
+
+61
+00:05:43,890 --> 00:05:49,830
+و احنا من هنا ايش دور الوضوء في منع المرض شوف يعني
+
+62
+00:05:49,830 --> 00:05:54,430
+لما قال النبي صلى الله عليه وسلم قرأت لو انا ببابي
+
+63
+00:05:54,430 --> 00:06:01,610
+احدكم نهرا هيختسروا فيه خمس مرات في اليوم هيبقى
+
+64
+00:06:01,610 --> 00:06:07,170
+ذلك من درانه شيئا الاوساخ اللي قاله بظل لو استحمت
+
+65
+00:06:07,170 --> 00:06:12,830
+خمس مرات في النهربيخلّي عليه أدران يعني أوساخ و
+
+66
+00:06:12,830 --> 00:06:15,890
+عراج و إشي قالوا لأ يا رسول الله قاد كذلك الصلاوات
+
+67
+00:06:15,890 --> 00:06:20,870
+و الخمس يمحوا الله بهم الخطايا يعني شوف التشبيه ما
+
+68
+00:06:20,870 --> 00:06:25,350
+أجمله يعني نهر ماشي قدام باب دارك تقطص فيه خمس
+
+69
+00:06:25,350 --> 00:06:30,990
+مرات بيخلّي أوسخ و عراج و غبر عليك قال لأ قالوا لأ
+
+70
+00:06:30,990 --> 00:06:34,790
+جاد الصلاوات الخمس هي كل واحد ما يزنب بصلي و
+
+71
+00:06:34,790 --> 00:06:39,700
+بستغفر تمحي الخطايا عنهيبقى هاجلة ايش دول الميّه
+
+72
+00:06:39,700 --> 00:06:46,680
+في الموضوع في مكافحة المرض التالت العامل التالت في
+
+73
+00:06:46,680 --> 00:06:50,800
+risk factors اللي هو عامل الخطر او المخاطرة في
+
+74
+00:06:50,800 --> 00:06:54,720
+اللي هو نشر هذا المرض poor sanitation poor
+
+75
+00:06:54,720 --> 00:07:00,500
+sanitation يعني الخدمات الصحية قليلة ضعيفة خدمات
+
+76
+00:07:00,500 --> 00:07:05,000
+الصحية زي ايه خدمات الصحية عدم توفر الدورات الميّه
+
+77
+00:07:07,320 --> 00:07:10,900
+Latterize اللي هو دورات الميه انتوا عارفين المناطق
+
+78
+00:07:10,900 --> 00:07:14,820
+الريفية و الزراعية و اشي يعني باهتموش بحكاية
+
+79
+00:07:14,820 --> 00:07:20,860
+توصيلات الميه للي بيوت و يكون في كورسي فرنجي و في
+
+80
+00:07:20,860 --> 00:07:26,640
+يعني مقصرة و في صابونة و في طيد و شامبو لأ يعني
+
+81
+00:07:26,640 --> 00:07:32,600
+الناس عارف اترا في الأرض الزراعية بروح بيعمل اللي
+
+82
+00:07:32,600 --> 00:07:40,690
+هويعني البول والبرادز وشيء وطبعا معروف ان هنا يعني
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+83
+00:07:40,690 --> 00:07:47,690
+هذا ذوباب بنجل يعني منه الى الناس يبقى لما يكون
+
+84
+00:07:47,690 --> 00:07:52,410
+فيه اصحاح كويس الذوباب احنا بنجد عليه هي هذه
+
+85
+00:07:52,410 --> 00:07:55,930
+الموضوع الشاهد ان الذوباب بيجي في ال poor
+
+86
+00:07:55,930 --> 00:07:59,650
+sanitation اما في ال good sanitation بيختفي
+
+87
+00:07:59,650 --> 00:08:06,890
+الذوبابما هي أهم الخطر البيئية اللى فيه انتشار
+
+88
+00:08:06,890 --> 00:08:14,410
+الكراكومة ال crowd و قلة مياه limited water supply
+
+89
+00:08:14,410 --> 00:08:19,330
+و poor sanitation وتخدمات الصحية قليلة control كيف
+
+90
+00:08:19,330 --> 00:08:25,070
+نسيطر عليها بقول احنا لو سيطرنا على مجتمع الدباب
+
+91
+00:08:25,070 --> 00:08:32,350
+fly population باستخدام ال insecticidesInsecticide
+
+92
+00:08:32,350 --> 00:08:38,610
+Spraying يعني رش الدباب بالمبيضات الحشرية وهي
+
+93
+00:08:38,610 --> 00:08:45,730
+كتيرة وامداد المنطقة بال دورات الميه اللي فيها
+
+94
+00:08:45,730 --> 00:08:51,230
+يعني عوامل صحية حنافيات وفيها يعني صابونة وفيها
+
+95
+00:08:51,230 --> 00:08:59,850
+مغاسل هذا بيحسن كتير من انتشار المرض او بيجلل من
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+96
+00:08:59,850 --> 00:09:04,000
+انتشار المرضيبقى ال control يعني كيف نسيطر على
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+97
+00:09:04,000 --> 00:09:10,920
+المرض انه احنا نكافح الذباب اه بيقولوا combat fly
+
+98
+00:09:10,920 --> 00:09:28,380
+population combat يعني مكافح c o m v a t combat بس
+
+99
+00:09:28,380 --> 00:09:33,430
+الخط طبعا بالماوسيده بيطلعش مرسوم زي الجنان هذه
+
+100
+00:09:33,430 --> 00:09:39,230
+كمباب هذه سيك ايش كمباب كم مكافحة مكافحة الذباب
+
+101
+00:09:39,230 --> 00:09:48,490
+لرش اللي هو الحشرات هذه بالمبيدات الحشرية رش يعني
+
+102
+00:09:48,490 --> 00:09:55,990
+اللي هو توفر دورات الميه الكافية لليه قضاء الحاجة
+
+103
+00:09:55,990 --> 00:10:00,350
+في الشوارع وفي الأراضي الزراعيةخلصنا احنا هيك
+
+104
+00:10:00,350 --> 00:10:04,870
+اتراكومة اوكلو اتراكومة يعني خلصنا اتراكومة
+
+105
+00:10:04,870 --> 00:10:10,830
+العادية اللى من I to I طيب الآن التراكومة الجنسية
+
+106
+00:10:10,830 --> 00:10:15,090
+اللى بتيجي من العضاء الجنسية و بتسيب العين هذه
+
+107
+00:10:15,090 --> 00:10:20,370
+اسمها Adult Inclusion Congeractivitis وسمناها قبل
+
+108
+00:10:20,370 --> 00:10:28,170
+شوية Paratracoma شبيهة تراكومة Para هيك Para Para
+
+109
+00:10:40,820 --> 00:10:44,140
+تراكومة التراكومة التراكومة التراكومة التراكومة
+
+110
+00:10:44,140 --> 00:10:45,680
+التراكومة التراكومة التراكومة التراكومة التراكومة
+
+111
+00:10:45,680 --> 00:10:46,540
+التراكومة التراكومة التراكومة التراكومة التراكومة
+
+112
+00:10:46,540 --> 00:10:47,160
+التراكومة التراكومة التراكومة التراكومة التراكومة
+
+113
+00:10:47,160 --> 00:10:52,360
+التراكومة التراكومة التراكومة التراكومة التراكومة
+
+114
+00:10:52,360 --> 00:10:53,640
+التراكومة التراكومة التراكومة التراكومة التراكومة
+
+115
+00:10:53,640 --> 00:10:53,680
+التراكومة التراكومة التراكومة التراكومة التراكومة
+
+116
+00:10:53,680 --> 00:11:02,240
+التراكومة التراكومة التراكومة التراكومة التراكوم
+
+117
+00:11:02,630 --> 00:11:08,530
+هذا يقول دي و ك دي و ك هذه صح طيب بيقول انه بتعمل
+
+118
+00:11:08,530 --> 00:11:14,030
+punctate keratoconjunctivitis تنقيد سطح القرنية و
+
+119
+00:11:14,030 --> 00:11:19,630
+الملتحمة وهذا بيقول انه يعتقد انه بتيجي من ال
+
+120
+00:11:19,630 --> 00:11:24,330
+genital tract to eye to the eye تنتقل من الأعضاء
+
+121
+00:11:24,330 --> 00:11:29,090
+الدينسية في الذكر و الأنثى إلى اللي هو إيش إلى
+
+122
+00:11:29,090 --> 00:11:35,250
+العينممكن من نفس الشخص انه كون هو مصاب و بيحك في
+
+123
+00:11:35,250 --> 00:11:39,990
+أعضاه التناثورية وبعدين بيحك في عينه صاحب ولا نايم
+
+124
+00:11:39,990 --> 00:11:44,890
+او من ال partner اللي هو شريكه في الفراش غالبا
+
+125
+00:11:44,890 --> 00:11:50,650
+الزوج او الزوجة بيقعدوا بعض يعنى بقول انه وجدوا ان
+
+126
+00:11:50,650 --> 00:11:57,670
+2% من اليهبات الملتحمةفي الدول المتطورة بتجي من
+
+127
+00:11:57,670 --> 00:12:04,330
+اللي هو ال sexual trachoma 2% من عدوى العين او
+
+128
+00:12:04,330 --> 00:12:12,170
+التهابات العين بقول انه يعني 50 الى 70% من الأشخاص
+
+129
+00:12:12,170 --> 00:12:21,230
+اللي عندهم مرض جنسي سببه trachoma D و K عندهم
+
+130
+00:12:21,230 --> 00:12:29,280
+في العينوفي الأعضاء التناثولية يعني 70% لو فحصنا
+
+131
+00:12:29,280 --> 00:12:36,880
+لجينا في عينه فيها Trachoma وفحصنا
+
+132
+00:12:36,880 --> 00:12:42,780
+أعضاء التناثولية بيجينا 50-70% جمعوا بينهما بين
+
+133
+00:12:42,780 --> 00:12:48,220
+التنتين لكن بيقوللي على العكس ان واحد من ال 300
+
+134
+00:12:48,220 --> 00:12:56,900
+اللي عنده أساسا أكل Trachoma بنصاببالجنس يعني هي
+
+135
+00:12:56,900 --> 00:13:00,340
+زي ما أنا كاتب تنتقل من الأعضاء التناثولية للعين
+
+136
+00:13:00,340 --> 00:13:06,700
+سهلة لكن صعب تنتقل من العين إلى الأعضاء التناثولية
+
+137
+00:13:06,700 --> 00:13:12,380
+صعب أن تنزل يعني هي صعدة من تحت لفوق آه لكن مش
+
+138
+00:13:12,380 --> 00:13:15,880
+نازة من العين إلى تحت يعني الأعضاء التناثولية
+
+139
+00:13:15,880 --> 00:13:21,520
+قليلا تقعد من العين لكنالعين تعدى كثير من أعضاء
+
+140
+00:13:21,520 --> 00:13:25,900
+التناثولية وانا مش عارف ايش الحكمة في هذه التوزيع
+
+141
+00:13:25,900 --> 00:13:31,900
+طيب ايش هي الأعراض بتاعك اللي هو التراكومر راحت
+
+142
+00:13:31,900 --> 00:13:34,940
+على العين من اللي هو الأعضاء التناثولية بقول اول
+
+143
+00:13:34,940 --> 00:13:40,160
+اشي بنلاقي water discharge عينه بتدمع بصورة متوسطة
+
+144
+00:13:40,160 --> 00:13:46,190
+مدرت بصورة متوسطةهذه جدا يعني الواحد ممكن تشخصها
+
+145
+00:13:46,190 --> 00:13:51,330
+من تير حاسية حاجة بتعمل water discharge و فيروسات
+
+146
+00:13:51,330 --> 00:13:58,290
+لكن لما يصير eyelid swelling آه علامة جديدة bad
+
+147
+00:13:58,290 --> 00:14:02,270
+redness حمار عينين آه photophobia بصير يكره الضوء
+
+148
+00:14:02,270 --> 00:14:05,650
+و يروع العتمة foreign body sensation بيقولك في
+
+149
+00:14:05,650 --> 00:14:09,830
+عينيه رمل آه هذا في عينيه رمل لو جلبت جفنه بلاقي
+
+150
+00:14:09,830 --> 00:14:16,190
+folliclesالفريكلز غالبا تجمعات خلال الانفعوية
+
+151
+00:14:16,190 --> 00:14:22,570
+استجابة لهجوم كلاميديا و Trachomatis دي و كي طيب
+
+152
+00:14:22,570 --> 00:14:29,810
+الآن قلنا انه بتعمل كيراتو
+
+153
+00:14:29,810 --> 00:14:34,650
+كنجستبيرتس تنقيت على سطح القرنية و سطح الملتحمة اه
+
+154
+00:14:34,650 --> 00:14:40,280
+و ممكن تعمل sub-epithelialإيه subepithelial
+
+155
+00:14:40,280 --> 00:14:45,700
+metastasis يعني نوع من العتامات في ال bowens
+
+156
+00:14:45,700 --> 00:14:51,560
+membrane وممكن تحت ال bowens membrane ورا أعمق من
+
+157
+00:14:51,560 --> 00:14:56,200
+ال epithelium يعني تشبه
+
+158
+00:14:56,990 --> 00:14:59,750
+اللي هما بيعملها ادينو بايروس و هذا ادينو بايروس
+
+159
+00:14:59,750 --> 00:15:04,910
+الشين اللي مابيه دي بيعمل يعني حاجات في اللي هو
+
+160
+00:15:04,910 --> 00:15:10,010
+البومازم ال brain عتمال و هذه صحيح ان انا بتأثر
+
+161
+00:15:10,010 --> 00:15:16,310
+على النظر بس مش زي اللي هو ال tracheosis و ال
+
+162
+00:15:16,310 --> 00:15:21,590
+introperable لا اجل اجل طيب بقول ان هذا المفروض
+
+163
+00:15:21,590 --> 00:15:29,450
+يكون self limiting يعني ان هو ينتهي لحالهاللي كان
+
+164
+00:15:29,450 --> 00:15:34,750
+يظل الإنسان يحق في عينه ويعني دايما الأعضاء
+
+165
+00:15:34,750 --> 00:15:39,410
+التناسية يحق في عينه ممكن أنه تصير endemic اتركومة
+
+166
+00:15:39,410 --> 00:15:44,970
+endemic أي متوطنة في العين متوطنة في العين طيب
+
+167
+00:15:44,970 --> 00:15:52,570
+قلنا انه الاتركومة اللي بتيجي من العضايا التناسية
+
+168
+00:15:52,570 --> 00:15:59,840
+زادت هذه الأياميعني العالم أصبح منفتح و أصبح فيه
+
+169
+00:15:59,840 --> 00:16:05,000
+ممارسات شاذة بين الجنسين ف increasing common
+
+170
+00:16:05,000 --> 00:16:08,940
+sexually transmitted infection worldwide على مستوى
+
+171
+00:16:08,940 --> 00:16:13,600
+العالم حتى أصبحت تسعين مليون واحد مصاب في أعضاء
+
+172
+00:16:13,600 --> 00:16:16,840
+التناثولية تسعين مليون و الأن أكتر من تسعين مليون
+
+173
+00:16:16,840 --> 00:16:21,900
+في العالم مصابين بالأعضاء التناثولية اللي مصاب
+
+174
+00:16:21,900 --> 00:16:26,270
+باتركوم التناثوليةماذا يشك في أعضاء التنسوية يعني
+
+175
+00:16:26,270 --> 00:16:29,990
+احنا عرفنا ايش بيشك في العين عرفنا هنا ايش بيشك في
+
+176
+00:16:29,990 --> 00:16:33,930
+العين قولنا انه water discharge و swelling و
+
+177
+00:16:33,930 --> 00:16:38,070
+redness و photophobia و phornic sensation و لما
+
+178
+00:16:38,070 --> 00:16:42,910
+فحصنا لجنا عنده punctate كره تكون جالس ببس مظبوط
+
+179
+00:16:42,910 --> 00:16:48,850
+هيك طيب هو نفسه اللي عنده ترقومة جنسية ترقومة
+
+180
+00:16:48,850 --> 00:16:54,300
+جنسيةالتنسوية في الجنسين الذكر والأنثى بيشكي
+
+181
+00:16:54,300 --> 00:16:59,320
+اقلامي يوريسرايتس كلمة يوريسرا قناة الإحليل اللي
+
+182
+00:16:59,320 --> 00:17:03,840
+هي تكون طويلة في الذكر وقصيرة في الأنثى طبعا هذه
+
+183
+00:17:03,840 --> 00:17:08,660
+في حرجان يعني بيحس بحرجان و بيحس بألم في البول
+
+184
+00:17:08,660 --> 00:17:16,760
+كلمة dysuria يعني ألم في التبون اه وبعدين
+
+185
+00:17:16,760 --> 00:17:22,520
+discharge بصير ينزل شئ زن مخاطمن اللي هو العضاء
+
+186
+00:17:22,520 --> 00:17:26,140
+التناثري بعدين frequency of urination يعني كل شوية
+
+187
+00:17:26,140 --> 00:17:31,860
+نفسه يروح يعمل ball في الحمام هذي eosritis في
+
+188
+00:17:31,860 --> 00:17:37,160
+الأنثى في شيء اسمه cervix fry انخ الرحم لو تحصوا
+
+189
+00:17:37,160 --> 00:17:46,160
+انخ الرحم هيلاجوها ملتهبة يعني هاي الرحم هيك وهيك
+
+190
+00:17:48,710 --> 00:17:55,870
+هذه المنطقة دقيقة اسمها cervix vitrei لو
+
+191
+00:17:55,870 --> 00:18:02,250
+فحصوا cervix vitrei حيلاجوا ملتهي و لو أخدوا منه
+
+192
+00:18:02,250 --> 00:18:07,590
+مسحة و حطوا جمزة ستان حيلاجوا انه مصاب ب Trauma
+
+193
+00:18:07,590 --> 00:18:14,190
+طيب و ممكن يكون asymptomatic هذا ممكن يكون بنزل
+
+194
+00:18:14,190 --> 00:18:20,930
+شوية الشعرالعين وسط العين لأ العين هسير فيه
+
+195
+00:18:20,930 --> 00:18:26,590
+discharge ميوكو بيربلاند يعني همخاطي وصديري
+
+196
+00:18:26,590 --> 00:18:32,170
+وhyperemia و folicles ممكن نلاقي folicles في العين
+
+197
+00:18:32,170 --> 00:18:36,190
+ولو صدرنا القرنية ممكن نلاقي keratopathy ممكن
+
+198
+00:18:36,190 --> 00:18:41,770
+نلاقي keratopathy طيب كلمة Erogens تشققات صغيرة
+
+199
+00:18:41,770 --> 00:18:46,570
+وfolicles يعني اللي هي الحبيباتيقولوا رمض حبيبي
+
+200
+00:18:46,570 --> 00:18:56,150
+عنه رمض حبيبي طيب الآن امرأة حامل وولدت
+
+201
+00:18:56,150 --> 00:19:02,170
+مولودا في نهاية الحمل المولود هذا هو داخل من قناة
+
+202
+00:19:02,170 --> 00:19:09,770
+الحمل during passage يعني هو طالع عبر قناة الحمل
+
+203
+00:19:09,770 --> 00:19:11,890
+من infected cervix
+
+204
+00:19:14,560 --> 00:19:22,500
+الأم اللى بتسعانى من التراكومة الجنسية بقول 18% من
+
+205
+00:19:22,500 --> 00:19:29,080
+ال babies اللى بنولدوا أمهات عندهم مرض جنسى
+
+206
+00:19:29,080 --> 00:19:40,400
+تراكومة بنصابوا يعني حوالى 5% من الموليد اللى
+
+207
+00:19:40,400 --> 00:19:48,110
+أمهاتهم فيهميعني تراكومة جنسية في عنق الرحم بنصابه
+
+208
+00:19:48,110 --> 00:19:51,770
+في عينيهم بنصاب وين في عينيهم بنصابه في عينيهم
+
+209
+00:19:51,770 --> 00:19:56,050
+وبيولد و هو عنده افطالميا نيوناتورام احنا افطالميا
+
+210
+00:19:56,050 --> 00:19:59,970
+نيوناتورام اتكلمنا عنها في النساء اللي بيكونوا
+
+211
+00:19:59,970 --> 00:20:05,930
+مصابين بالجنورية مرض السيالان الجنسي الخطير اللي
+
+212
+00:20:05,930 --> 00:20:12,380
+بعمل عكملأ هذه طعم نوتروم بس بكتيريا مش انه ساريا
+
+213
+00:20:12,380 --> 00:20:19,000
+جونورية لأ كلاميديا تراكوماتس و دي وكي اللي هو
+
+214
+00:20:19,000 --> 00:20:23,460
+كلاميديا تراكوماتس بقول انه الود صغير مسكين
+
+215
+00:20:23,460 --> 00:20:28,980
+بياخدها في عينيه بتبين بعد خمسة الاربعتاشر يوم في
+
+216
+00:20:28,980 --> 00:20:35,000
+فترة الحضانة مش من اول يوم بتبين5 الى 14 يوم لما
+
+217
+00:20:35,000 --> 00:20:38,800
+يبدأ المسكين يشكى يشكى من ايش في عينيه تنتين
+
+218
+00:20:38,800 --> 00:20:43,320
+الموجودة جديد Excessive tearing يعني عينيه بيضلهم
+
+219
+00:20:43,320 --> 00:20:48,580
+يدمعوا كتير وبعدين بيصير فيهم صديد ميوكوبرانت
+
+220
+00:20:48,580 --> 00:20:55,140
+ديشارد وصيروا مجفرين صديد وبعدين ورم لجفون العين
+
+221
+00:20:55,140 --> 00:20:59,600
+مع حمار في العين ارثيمة يعني حمار في العين هذه
+
+222
+00:20:59,600 --> 00:21:07,130
+صورةيعني ولد صغير هيومولود وبين عليه بعد اسبوعين
+
+223
+00:21:07,130 --> 00:21:10,890
+خمس أيام إلى اسبوعين اللي هو ophthalmia
+
+224
+00:21:10,890 --> 00:21:18,430
+neonatorium طيب البلبر
+
+225
+00:21:18,430 --> 00:21:23,650
+كل ذلك طيبه يكون hyperemic يعني حمرة محتقنة
+
+226
+00:21:23,650 --> 00:21:30,550
+hyperemic القرانية قد تبقى normal و قد تصابوكتب
+
+227
+00:21:30,550 --> 00:21:36,450
+فانومل حسب العلاج التاصل كله طيبة حتكون حماء لما
+
+228
+00:21:36,450 --> 00:21:43,370
+نجلب الجفن حمرا وفيها فكلي غيرة فكلي حليمات يعني
+
+229
+00:21:43,370 --> 00:21:47,650
+زي انت شفتهها قبل هيك بس أصغر small وهي تجيب ال
+
+230
+00:21:47,650 --> 00:21:52,330
+lymphocytes من خلايا الليمفاوية اذا كان لم يعالج
+
+231
+00:21:52,330 --> 00:21:57,190
+هذا الخطر عادي untreated العين هذه لم تعالج اه
+
+232
+00:21:57,190 --> 00:22:04,420
+ممكن تظلها monthsأو years يعني شهورا او سنين اه
+
+233
+00:22:04,420 --> 00:22:10,140
+ليه اللي هو وجود اللي هو ما موجود اللي هو ال
+
+234
+00:22:10,140 --> 00:22:15,540
+follicles القبيبات و البنص اللي هو او عيادة دم
+
+235
+00:22:15,540 --> 00:22:21,640
+متمددة و scarring ممكن يسيب اللي هو الملتحمة و
+
+236
+00:22:21,640 --> 00:22:27,060
+يصير similiformأنا طبعا شكرا لكم على تلقيكم هذه
+
+237
+00:22:27,060 --> 00:22:31,780
+المحاضرة بإعراض حابة لكن أنا الإنجاز اللى عملته في
+
+238
+00:22:31,780 --> 00:22:35,520
+هذه المحاضرة ان انا انتهيت من التراكوما اللى هي
+
+239
+00:22:35,520 --> 00:22:40,740
+المرض المزمن اللى يشهر العمى في ربوع العالم خاصة
+
+240
+00:22:40,740 --> 00:22:46,480
+في الأطفال ففهم هذا الموضوع فهما جيدا و كتير شيق و
+
+241
+00:22:46,480 --> 00:22:49,860
+كتير هينفعكم في المستقبل انا شكرا لكم و ان شاء
+
+242
+00:22:49,860 --> 00:22:55,270
+الله نكون في المحاضرة الجايةفي اللي هو فيروسات
+
+243
+00:22:55,270 --> 00:23:01,010
+العين فيروسات التي تسيب العين وأهم حاجة انا عندي
+
+244
+00:23:01,010 --> 00:23:05,870
+انه تبدأوا من الآن تستعدوا لما هو قاد تستعدوا لما
+
+245
+00:23:05,870 --> 00:23:06,350
+هو قاد
+
diff --git a/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/aIAPgbyi53Q_raw.srt b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/aIAPgbyi53Q_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..da633e1f3661cb3c41d55f63253c71357be3eeda
--- /dev/null
+++ b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/aIAPgbyi53Q_raw.srt
@@ -0,0 +1,1044 @@
+1
+00:00:00,000 --> 00:00:03,660
+أعوذ بالله من الشيطان الرجيم بسم الله الرحمن
+
+2
+00:00:03,660 --> 00:00:07,500
+الرحيم الحمد لله وكفا و أصلي و أسلم على النبي
+
+3
+00:00:07,500 --> 00:00:12,940
+المصطفى طالباتي في قسم البصريات الطبية المستوى
+
+4
+00:00:12,940 --> 00:00:17,720
+الثالث مساقل حياة دقيقة السلام عليكم ورحمة الله
+
+5
+00:00:17,720 --> 00:00:23,140
+وبركاته إن مما يسعدني أن ألتقي بكم في هذه المحاضرة
+
+6
+00:00:23,140 --> 00:00:28,280
+الثالثة لنكمل ما كنا قد بدأنا في هذا المساقل جيد
+
+7
+00:00:28,850 --> 00:00:35,090
+اليوم ان شاء الله سوف نتحدث عن احتياجات النمو
+
+8
+00:00:35,090 --> 00:00:41,070
+البكتيري احتياجات النمو البكتيري bacterial growth
+
+9
+00:00:41,070 --> 00:00:46,310
+requirements growth يعني نمو requirements يعني
+
+10
+00:00:46,310 --> 00:00:51,750
+متطلباتمطلبات النمو البكتيري يعني زي الإنسان هل
+
+11
+00:00:51,750 --> 00:00:58,830
+الإنسان ينمو بدون طعام وشراب وهواء كما أن للإنسان
+
+12
+00:00:58,830 --> 00:01:04,630
+متطلبات من الطعام والشراب والهواء فإن للبكتيريا
+
+13
+00:01:04,630 --> 00:01:11,170
+لكي تنمو وتنقسم وتعيش أيضا متطلبات من الطعام
+
+14
+00:01:11,170 --> 00:01:17,690
+والشراب والهواءالان هنجسم احنا هذه المطالبات اللى
+
+15
+00:01:17,690 --> 00:01:23,630
+اسمها requirements المطالبات إلى تلاتة انواع فيه
+
+16
+00:01:23,630 --> 00:01:28,980
+انواع اسمه nutritional اي غذائي nutritionalوفي نوع
+
+17
+00:01:28,980 --> 00:01:34,260
+تاني اسمه gasius يعني غازي مطالبات غازية النوع
+
+18
+00:01:34,260 --> 00:01:37,020
+الثالث ماتيم بريتشار اسم ماتيم بريتشار يعني
+
+19
+00:01:37,020 --> 00:01:44,040
+المطالبات اللي هو الحرارية الحرارة من يعني لحبل
+
+20
+00:01:44,040 --> 00:01:47,540
+البكتيريا احنا طبعا هنبدأ في ال nutritional وهي
+
+21
+00:01:47,540 --> 00:01:51,760
+أهم واحدة nutritional البكتيريا من ناحية اللي
+
+22
+00:01:51,760 --> 00:01:58,370
+تغذية يعني تنقسم إلى قسمينفي قسم autotrophic و في
+
+23
+00:01:58,370 --> 00:02:03,570
+قسم heterotrophic ايش هو autotrophic يعني بسيط
+
+24
+00:02:03,570 --> 00:02:08,530
+التغرية يعني التغرية بتاعته بسيطة برضه بأي حاجة زي
+
+25
+00:02:08,530 --> 00:02:14,710
+الإنسان الفقير اللي برضه بلجمة خبزة بجبنة بأي حاجة
+
+26
+00:02:14,710 --> 00:02:18,970
+لكن heterotrophic زي الإنسان اللي بده اللحمة و بده
+
+27
+00:02:18,970 --> 00:02:24,010
+الكبدة و بده المشاويالـ autotrophic هذه بكتيريا
+
+28
+00:02:24,010 --> 00:02:31,290
+طبعا غاضبة انها بسيطة انه يتراجى يعني تستعمل بس in
+
+29
+00:02:31,290 --> 00:02:37,210
+organic salts املاح غيررضوية in organic املاح
+
+30
+00:02:37,210 --> 00:02:42,110
+غيررضوية وتستخدم ثاني اكسيد الكربون ثاني اكسيد
+
+31
+00:02:42,110 --> 00:02:47,810
+الكربون CO2 يعني ثاني اكسيد الكربون طب تستخدم
+
+32
+00:02:47,810 --> 00:02:53,860
+الميهكمان و بتعيش في التراب في التربة اشي يعني
+
+33
+00:02:53,860 --> 00:02:58,400
+غالبا هذه autotrophic بكتيريا غير مرضية عشان هي
+
+34
+00:02:58,400 --> 00:03:02,760
+سموها بكتيريا بسيطة التغذية autotrophic بسيطة
+
+35
+00:03:02,760 --> 00:03:09,260
+التغذية بس اعطيها يعني املح و اعطيها ثاني كسيل
+
+36
+00:03:09,260 --> 00:03:15,290
+الكربون وميه و خلاص بتعيش في الهواءلكن البكتيريا
+
+37
+00:03:15,290 --> 00:03:19,910
+الأخطر والأعقد هي الـ heterotrophic اللي هو طلبتها
+
+38
+00:03:19,910 --> 00:03:27,290
+الغذائية معقدة يعني راقية هذه تستبدها مواد عضوية
+
+39
+00:03:27,290 --> 00:03:32,730
+organic هو أعني بالعضوية زي بروتينات مثلا بروتينات
+
+40
+00:03:32,730 --> 00:03:39,220
+يعني organic حاجات يعني فيها بروتينو بتستخدم كمان
+
+41
+00:03:39,220 --> 00:03:45,900
+carbohydrates اللي هو النشويات والسكريات تستخدم ال
+
+42
+00:03:45,900 --> 00:03:53,080
+fats اللي هو الذهون و البروتينان عشان تنمو وتنقصر
+
+43
+00:03:53,080 --> 00:03:57,080
+يبقى هذه الفكتيريا لا شك ال heterotrophic أخطر و
+
+44
+00:03:57,080 --> 00:04:02,840
+أعقد في التغذية و في تسبيب الأمراضمن البكتيريا الـ
+
+45
+00:04:02,840 --> 00:04:05,600
+autotrophic عشان ايه بيقوللي انه most of
+
+46
+00:04:05,600 --> 00:04:09,420
+pathogenic بكتيريا يعني التي تسبب الأمراض معظم
+
+47
+00:04:09,420 --> 00:04:12,560
+البكتيريا التي تسبب الأمراض هي heterotrophic هي
+
+48
+00:04:12,560 --> 00:04:17,720
+اللي يعني تغييتها معقدة تغييتها معقدة هذا بالنسبة
+
+49
+00:04:17,720 --> 00:04:21,580
+للجانب الأول متطلبات غذائية autotrophic او
+
+50
+00:04:21,580 --> 00:04:28,000
+heterotrophic طيب نشوف المتطلب التاني gaseous يعني
+
+51
+00:04:28,000 --> 00:04:34,590
+غازيالبكتيريا بالنسبة للغازية تتقسم إلى أربعة
+
+52
+00:04:34,590 --> 00:04:40,250
+أقسام ما هي أربعة أقسام سنقولها بس بنوط و بعدين
+
+53
+00:04:40,250 --> 00:04:46,950
+نشرح Obligate يعني إجباري Obligate Aerobic بكتيريا
+
+54
+00:04:46,950 --> 00:04:51,470
+يعني بكتيريا هوائية إجبارية لا تعيش إلا في
+
+55
+00:04:51,470 --> 00:04:56,130
+الأكسجين هوائية أكسجين يعني التانية Obligate
+
+56
+00:04:56,130 --> 00:04:57,350
+Anaerobic
+
+57
+00:05:01,300 --> 00:05:07,660
+نفي Obligate anaerobic يعني بكتيريا لهوائية
+
+58
+00:05:07,660 --> 00:05:13,300
+إجبارية لهوائية إجبارية التاريث facultative يعني
+
+59
+00:05:13,300 --> 00:05:17,300
+اختيارية facultative anaerobic facultative
+
+60
+00:05:17,300 --> 00:05:24,830
+anaerobic الرابع aeroTolerance ايرو توليرانت اي
+
+61
+00:05:24,830 --> 00:05:30,810
+انها تتحمل الاكسجين الايرو يعني الهواء توليرانت
+
+62
+00:05:30,810 --> 00:05:36,630
+يعني تتحمل اللي هو ال anaerobes تتحمل الاكسجين
+
+63
+00:05:36,630 --> 00:05:43,990
+القليل و ثاني اكسجن الكربون يعني عوجهين نبدأ
+
+64
+00:05:43,990 --> 00:05:52,480
+بالابليجيات الابليجيات aerobe اه بكتيريا هذهتحتاج
+
+65
+00:05:52,480 --> 00:05:56,480
+إلى أكسجين ضروري للنمو من غياب الأكسجين فإنها تموت
+
+66
+00:05:56,480 --> 00:06:00,280
+يبقى في ال absence of أكسجين they will die يعني
+
+67
+00:06:00,280 --> 00:06:04,360
+تموت تموت في غياب الأكسجين شيء سموها هوائية
+
+68
+00:06:04,360 --> 00:06:09,660
+إجبارية وأقصد الهوائية يعني أكسجين طيب عكسها
+
+69
+00:06:09,660 --> 00:06:19,220
+obligate an aerobic يعني هذه فقط تعيش في غياب
+
+70
+00:06:19,220 --> 00:06:23,870
+الأكسجينإيه تخياب الأكسجين يعني؟ يعني ثاني أكسجن
+
+71
+00:06:23,870 --> 00:06:28,370
+الكربون وهذه البكتيريا اللي بتكون في الجروح
+
+72
+00:06:28,370 --> 00:06:31,830
+العميقة يعني لو واحد ممكن صاب برصاصة جوه جوه في
+
+73
+00:06:31,830 --> 00:06:36,910
+لحمه أو مصمغ جوه جوه في كعبه بتلاقي البكتيريا هذه
+
+74
+00:06:36,910 --> 00:06:42,210
+مدفونة بعيد تعيش على ثاني أكسجن الكربون على أنه
+
+75
+00:06:42,210 --> 00:06:44,730
+مافيش أكسجين مدخنها ثاني أكسجين بتموت
+
+76
+00:06:47,780 --> 00:06:53,040
+ان اياروب اي انها لا تعيش في الاكسجين وتعيش في عكس
+
+77
+00:06:53,040 --> 00:06:56,260
+الاكسجين وتعيش في عكس الاكسجين اللي هو ثاني اكسجن
+
+78
+00:06:56,260 --> 00:07:01,400
+الكرمون يبقى هنا بقول لي ان هذه البكتيريا في وجود
+
+79
+00:07:01,400 --> 00:07:09,020
+الاكسجينبصير harmful لها يعني ضارب وحتى قاتل
+
+80
+00:07:09,020 --> 00:07:13,220
+lethal قاتل اي الاكسجين يقتلها عشان هيك احنا كنا
+
+81
+00:07:13,220 --> 00:07:18,560
+زمان لما واحد مثلا بنصاب بطلق او بنصاب يعني بمصمار
+
+82
+00:07:18,560 --> 00:07:24,220
+عميق في لحمه بنحطله مية اكسجين مية الاكسجين هذه
+
+83
+00:07:24,220 --> 00:07:28,280
+عبارة عن مية وفيها ضرر اكسجين زيادة لما احنا
+
+84
+00:07:28,280 --> 00:07:33,380
+ندخلها جوا جوا جوا في الجريحبنطرق منها اكسيجين رغم
+
+85
+00:07:33,380 --> 00:07:38,540
+و هيك بتشطش وهذا بتطهر الجريح او بقتل البكتيريا
+
+86
+00:07:38,540 --> 00:07:43,080
+اللاهوائية يعني الاكسيجين lethal او harmful لها
+
+87
+00:07:43,080 --> 00:07:51,100
+يعني يقتلها يبقى اول نوع هوائية إجبارية ثاني نوع
+
+88
+00:07:51,100 --> 00:07:57,100
+لاهوائية إجبارية عكس بعض تماما اللي بيحير ال COD
+
+89
+00:07:59,250 --> 00:08:03,730
+بقول في نوع اسمه faculty of anaerobic لا هوائية
+
+90
+00:08:03,730 --> 00:08:08,630
+اختيارية طب ايش يعني لا هوائية اختيارية بقول والله
+
+91
+00:08:08,630 --> 00:08:13,610
+شوف هي anaerobic يعني هي بتحب ثاني اكسيد الكربون
+
+92
+00:08:13,610 --> 00:08:18,710
+بتحب ثاني اكسيد الكربون لكن ان اجا اكسيدين قليل
+
+93
+00:08:18,710 --> 00:08:26,170
+بتتحملوا وان اجا ثاني اكسيد الكربون قليل او كتير
+
+94
+00:08:26,170 --> 00:08:32,430
+بتتحملوا يعني هذهزي ما يقولون مجلبة بتعيش في
+
+95
+00:08:32,430 --> 00:08:36,410
+اكسجين جليل في ثاني اكسجين كربون جليل او كتير
+
+96
+00:08:36,410 --> 00:08:41,670
+المهم انه facultative اي اختيارية وهذه بعطيها قدرة
+
+97
+00:08:41,670 --> 00:08:48,110
+على تسبيب الامراض pathogenic bacteria لان هي تعيش
+
+98
+00:08:48,110 --> 00:08:51,890
+في اجواءزي اللي بيعيش في الجو البارد والجو الحار
+
+99
+00:08:51,890 --> 00:08:55,870
+مثلا فهذه بتعيش في اكسجين قليل في ثاني اكسجين
+
+100
+00:08:55,870 --> 00:09:00,490
+تربون قليل او كتير بتتحمل اللي هو المتغيرات
+
+101
+00:09:00,490 --> 00:09:06,850
+الغازية المتغيرات الغازية حولها البكتيريا الأخيرة
+
+102
+00:09:06,850 --> 00:09:13,350
+من ناحية الغاز aerotolerant anaerobic aerotolerant
+
+103
+00:09:13,350 --> 00:09:19,360
+anaerobicفتشبهى اللى جابلها بس بيقولى can tolerate
+
+104
+00:09:19,360 --> 00:09:25,340
+تتحمل the presence of low oxygen tension يعني هى
+
+105
+00:09:25,340 --> 00:09:29,980
+بتحب ثانو أكسيد الكربون بطمة may be killed by high
+
+106
+00:09:29,980 --> 00:09:34,360
+oxygen tension يعني اذا كان ضغط الأكسجين حولها زاد
+
+107
+00:09:34,360 --> 00:09:41,040
+تموت زاد الأكسجين تموت طب ايش الفرق بين ال aero
+
+108
+00:09:41,040 --> 00:09:45,540
+tolerantوالـ facultative لأ ال facultative لو زاد
+
+109
+00:09:45,540 --> 00:09:50,300
+أكسجين برضه بتعيش ولو زاد ثاني و ثاني كربون بتعيش
+
+110
+00:09:50,300 --> 00:09:54,500
+يعني هي صلبة ال facultative تستطيع ان تقاوم تغيرات
+
+111
+00:09:54,500 --> 00:10:00,300
+الغاز لكن ال aeroturant لأ يعني هي ان زاد أكسجين
+
+112
+00:10:00,300 --> 00:10:06,790
+بتموت لأن أساسا هي un-aerobicويعني تتعامل
+
+113
+00:10:06,790 --> 00:10:11,670
+الأكسيدين بدرجة مثلا 20% أو 30% لكن لو زاد فوق 50%
+
+114
+00:10:11,670 --> 00:10:17,530
+الأكسيدين فإنها تموت فإنها تموت يبقى ده احتياج
+
+115
+00:10:17,530 --> 00:10:23,330
+غازي يبقى احنا اتكلمنا عن الاحتياج اللي هو الطعام
+
+116
+00:10:23,330 --> 00:10:28,720
+او التغذيةAutotrophic وHetotrophic واتكلمنا على
+
+117
+00:10:28,720 --> 00:10:33,460
+الغازية على البكتيريا الغازية وقلنا انه اربع انواع
+
+118
+00:10:33,460 --> 00:10:39,720
+وبعدين ال timbre حقيقة هي بتشبه الانسان انه لها حد
+
+119
+00:10:39,720 --> 00:10:48,320
+ادنى من امام وحد اعلى حد اعلى وحد ادنى من الحرارة
+
+120
+00:10:50,140 --> 00:10:56,520
+بقول انه اقل من ال minimum بتموت و اكثر من ال
+
+121
+00:10:56,520 --> 00:11:01,680
+maximum بتموت و ال optimum المثالي 37 درجة زي
+
+122
+00:11:01,680 --> 00:11:07,500
+الإنسان يبقى البكتيريا 37 درجة بتعيش تماما يعني لو
+
+123
+00:11:07,500 --> 00:11:13,660
+احنا افترضنا ان انا عندي درجات او مدرج حراري مثلا
+
+124
+00:11:13,660 --> 00:11:19,760
+من الصفر الى مثلا ستين
+
+125
+00:11:21,770 --> 00:11:27,490
+ان حطيت البكتيريا كل ستر ماتت في الستين ماتت طيب
+
+126
+00:11:27,490 --> 00:11:31,890
+لو حطيتها انا في العشرة بتموت و لو حطيتها في
+
+127
+00:11:31,890 --> 00:11:38,630
+الخمسين بتموت في الخمسين بتموت طيب لو حطيتها انا
+
+128
+00:11:38,630 --> 00:11:46,210
+في العشرين اه بتعيش بالكاد العشرين بتعيش بالكاد طب
+
+129
+00:11:46,210 --> 00:11:53,550
+الأربعينبتعيش برضه بالكان طب ايه الحال الحال بيقول
+
+130
+00:11:53,550 --> 00:11:58,690
+احطه في سبعة و تلاتين السبعة و تلاتين درجة مئوية
+
+131
+00:11:58,690 --> 00:12:05,850
+centigrade هذا مثالي للنمو البكتيري كل ما اطلعت ل
+
+132
+00:12:05,850 --> 00:12:10,230
+.. ل .. لبوك للستين او زي التحت للصفر كل ما
+
+133
+00:12:10,230 --> 00:12:14,650
+بكتيريا كانت مهددة بالموت يعني مثلا انا بقعدت
+
+134
+00:12:14,650 --> 00:12:19,630
+البكتيريا في ال freezerتسعة وتسعين في المية منها
+
+135
+00:12:19,630 --> 00:12:23,330
+بعد مثلا تلت أبعاد ساعة بتموت طب راح تتمكّل في
+
+136
+00:12:23,330 --> 00:12:27,950
+المية المغلية أو سبعين درجة تسعة وتسعين أشهر بتموت
+
+137
+00:12:27,950 --> 00:12:36,790
+لأن هذه يا minimum البرد يا maximum الحر وال
+
+138
+00:12:36,790 --> 00:12:39,530
+optimum المثالي سبعة وتلاتين
+
+139
+00:12:42,800 --> 00:12:47,760
+هي الدرجة المطلقة لنمو البكتيريا عشان ايه احنا لما
+
+140
+00:12:47,760 --> 00:12:56,060
+بدنا نقتل البكتيريا يا بنبرد الأكل بنتلجه نفطه في
+
+141
+00:12:56,060 --> 00:13:00,980
+ال leave freezer يا اما بنسخنه و بنغليه يعني قبل
+
+142
+00:13:00,980 --> 00:13:07,280
+وجود التلاجات زمان كانوا الناس بيجيبوا الطعام في
+
+143
+00:13:07,280 --> 00:13:13,750
+الليل و بيغلوهكويس لمدة مثلا عشر دقائق و بيقتل
+
+144
+00:13:13,750 --> 00:13:17,950
+البكتيريا اللى فيه لما
+
+145
+00:13:17,950 --> 00:13:24,210
+طلع في التلاجات سعره بيحطه في التلاجة يعني اذا كان
+
+146
+00:13:24,210 --> 00:13:28,650
+فيه freezer احسن بيقتلها يبقى هيك احنا بنكون
+
+147
+00:13:28,650 --> 00:13:35,010
+عارفنا ايش المتصلبات البكتيريا اللى نمو فيهمطالبات
+
+148
+00:13:35,010 --> 00:13:39,730
+غرائية nutritional ومطالبات جاذية gaseous ومطالبات
+
+149
+00:13:39,730 --> 00:13:43,090
+حرارية temperature temperature وع فكرة ال
+
+150
+00:13:43,090 --> 00:13:49,730
+temperature بتحتوي ال ال ال ال ال heat وال cold
+
+151
+00:13:49,730 --> 00:13:55,770
+يعني ال heat الحرارة ان نرجع سبتين سبعين تمانين
+
+152
+00:13:55,770 --> 00:14:01,310
+فوقأو ال cold ال cold يعني انه نبرد لحوالي سفر او
+
+153
+00:14:01,310 --> 00:14:04,150
+خمس درجات هذا ال temperature يعني ال temperature
+
+154
+00:14:04,150 --> 00:14:08,090
+بيظهر بعض الناس بظن انه سخونة لا سخونة او برودة
+
+155
+00:14:08,090 --> 00:14:12,470
+سخونة او برودة عشان ذلك الجنة ربنا سبحانه وتعالى
+
+156
+00:14:12,470 --> 00:14:16,170
+في سورة الإنسان ايش بيقول لا يدوقون فيها بردا ولا
+
+157
+00:14:16,170 --> 00:14:22,230
+زمهاريرة لا يدوقون فيها بردا ولا زمهاريرةيعني
+
+158
+00:14:22,230 --> 00:14:27,230
+الجنة الجو معتدل لا في حرارة ولا في برودة نسأل
+
+159
+00:14:27,230 --> 00:14:32,470
+الله أن نكون جميعا أصحاب الجنة طيب هنتقل بسرعة إلى
+
+160
+00:14:32,470 --> 00:14:37,110
+منحنة النمو البكتيري البكتيريا لما جابوها حطوها في
+
+161
+00:14:37,110 --> 00:14:42,270
+وسط وحطوها المطالبات التلاتة اللي قلنا عنها قعدت
+
+162
+00:14:42,270 --> 00:14:47,970
+تنمو في وسط مناسب وفي الآخر اجوا عملوا plotting
+
+163
+00:14:47,970 --> 00:14:56,800
+رسم بيانيحيث وضعوا العدد الخلايا البكتيرية في
+
+164
+00:14:56,800 --> 00:15:04,320
+الوسط اللي بتنمو فيه مقابل الـTime زي هيك يعني هذا
+
+165
+00:15:04,320 --> 00:15:14,120
+أفقيًا الـTime وهنا رأسيًا الرأسيًا البكتيريا اللي
+
+166
+00:15:14,120 --> 00:15:19,380
+هو عدد البكتيريا أو جيب تمام البكتيريا يعني تعلق
+
+167
+00:15:19,380 --> 00:15:25,940
+بعددالان جاءوا انه لما رسموا هذا الرسم البياني طلع
+
+168
+00:15:25,940 --> 00:15:29,800
+لهم curve ال curve هذا من شايفين كيف ماشي هيك
+
+169
+00:15:29,800 --> 00:15:34,480
+وبعدين طلع هيك وبعدين صار أفقي وبعدين بدأ ينزل بدأ
+
+170
+00:15:34,480 --> 00:15:40,600
+ينزل رجع للحد الأدنى فقال سبحان الله يعني كيف نفهم
+
+171
+00:15:40,600 --> 00:15:48,380
+هذا المنحني البكتيري قالوا ان الرسم هذا بين لنا
+
+172
+00:15:48,380 --> 00:15:51,000
+أربع أطوار
+
+173
+00:15:57,040 --> 00:16:02,360
+of bacterial growth اربع أطوار من نمو البكتيريا
+
+174
+00:16:02,360 --> 00:16:09,400
+الطور الأول اسمه lag phase الكمون او الانتظار ال
+
+175
+00:16:09,400 --> 00:16:13,700
+face التالت اسمه log phase طور النشاط والانطلاق
+
+176
+00:16:13,700 --> 00:16:19,420
+الطور التالت اسمه stationary اي الثبات او الركود
+
+177
+00:16:19,420 --> 00:16:25,630
+او المراوحةالرابع ديكلاين الانخفاض او الانحدار
+
+178
+00:16:25,630 --> 00:16:31,870
+decline phase decline phase هنشرح كل واحد منهم ال
+
+179
+00:16:31,870 --> 00:16:36,310
+lag phase يعني بيقوللي انا حاطيت البكتيريا وحاطيت
+
+180
+00:16:36,310 --> 00:16:43,070
+لها متطلبات غرائية ومطلبات غازية مناسبة ومطلبات
+
+181
+00:16:43,070 --> 00:16:48,990
+حلوية لازمة بيقوللي افتخر وقت حتى تتأقلم to adapt
+
+182
+00:16:49,760 --> 00:16:58,320
+بكتيريا تتأقلم نفسها مع الوسط اللي هي فيه ربما
+
+183
+00:16:58,320 --> 00:17:03,920
+يمتد من ساعات إلى أيام في الفترة هذه البكتيريا
+
+184
+00:17:03,920 --> 00:17:13,140
+تتغذى وتنمو لكن لا تنقسم لا تنقسم أي مش زيادة في
+
+185
+00:17:13,140 --> 00:17:18,410
+العددإنما زيادة في ال size في ال size يعني
+
+186
+00:17:18,410 --> 00:17:23,390
+البكتيريا اللي كانت هيك أول ما بدأت نزرعها بعد يوم
+
+187
+00:17:23,390 --> 00:17:32,130
+صارت هيك بعد يومين صارت هيك مثلا يعني في نمو حجم
+
+188
+00:17:32,130 --> 00:17:39,750
+في حجم البكتيريا وليس نمو في ايش في اللي هو في
+
+189
+00:17:39,750 --> 00:17:46,080
+اللي هو زيادة في العدد فيش العدد دهطيب الآن بعد ان
+
+190
+00:17:46,080 --> 00:17:51,400
+البكتيري تتأقلم على الوسط تبدأ في ال log phase طور
+
+191
+00:17:51,400 --> 00:17:57,200
+الانقسام والزيادة يبقى الخلايا divide اي تنقسم
+
+192
+00:17:57,200 --> 00:18:01,660
+بالانقسام الثنائي الباقية اللي جوا nano binary
+
+193
+00:18:01,660 --> 00:18:03,620
+fission في المحاضرة السابقة
+
+194
+00:18:06,100 --> 00:18:10,640
+في معدل ثابت يعني الواحد بصير اتنين والاتنين بصير
+
+195
+00:18:10,640 --> 00:18:13,680
+اربعة والاربعة بصير تمانية والتمانية بصير ستاشر
+
+196
+00:18:13,680 --> 00:18:16,560
+ستاشر اتنين وتلاتين واتنين وتلاتين اربعة وستين
+
+197
+00:18:16,560 --> 00:18:19,060
+والاربعة وستين بصير مية و تمانية وعشرين وبعدين
+
+198
+00:18:19,060 --> 00:18:22,860
+بصيروا متين وستة وخمسين وهكذا يبقى في concentrate
+
+199
+00:18:24,260 --> 00:18:28,160
+وهذا يعتمد على طبيعة الوسط اللي انزلعت فيه
+
+200
+00:18:28,160 --> 00:18:34,100
+البكتيريا ان كان الوسط الغازي والوسط الغذائي
+
+201
+00:18:34,100 --> 00:18:39,060
+والحرارة مناسبة جدا كلها فالبكتيريا بتكون سريعة
+
+202
+00:18:39,060 --> 00:18:44,940
+سريعة سريعة كل تلت ساعة بتجيب ايش فوج كل تلت ساعة
+
+203
+00:18:44,940 --> 00:18:48,600
+فوج يعني اذا كانت واحد صارت اتنين واتنين صارت
+
+204
+00:18:48,600 --> 00:18:51,500
+اربعة والاربعة صارت تمانية وتمانية ستاشر وستاشر
+
+205
+00:18:51,500 --> 00:18:55,690
+اتنين وتلتين وتمانية اربعة وستينفي خلال ساعة على
+
+206
+00:18:55,690 --> 00:19:00,430
+طول كل تلسة ساعة هذا لما تكون كل الشروط اللي هي
+
+207
+00:19:00,430 --> 00:19:05,550
+المتطلبات النمو موجودة لكن لما تكون المتطلبات يعني
+
+208
+00:19:05,550 --> 00:19:10,130
+مش كلها يعني بعضها وبعضها يعني مناسبة مش بعضها
+
+209
+00:19:10,130 --> 00:19:17,690
+بتكون اللي هو الانقسام أبطأ من الحالة الأولى يقول
+
+210
+00:19:17,690 --> 00:19:23,500
+لي هذا ال tour بتاع ال long phaseهو الـtor الرئيسي
+
+211
+00:19:23,500 --> 00:19:28,700
+او الرئيس في الزيادة main phase of growth and
+
+212
+00:19:28,700 --> 00:19:31,920
+division مش بقى في growth and division division
+
+213
+00:19:31,920 --> 00:19:36,780
+يعني المنقسمة يعني هذا الـtor عشان هيك احنا لما
+
+214
+00:19:36,780 --> 00:19:43,560
+نشوف ال curve بنلاقي هذا الtor ال log هذا بدأ من
+
+215
+00:19:43,560 --> 00:19:51,520
+وين من هنا وانتهى هنا كله زي الصاروخ طالع هيكهنا
+
+216
+00:19:51,520 --> 00:19:56,740
+مثلا كانت جداش يعني عشر حبات يمكن هنا صاروا ألف
+
+217
+00:19:56,740 --> 00:20:04,260
+حبة ألف خلية بكتيرية بالجليل شايف كيف تصعدي؟ طيب
+
+218
+00:20:04,260 --> 00:20:09,260
+الآن الطور اللي بعده هذا الطور الأفقي اسمه
+
+219
+00:20:09,260 --> 00:20:17,450
+stationary stationary كيف يعني؟ انهلو احنا اعتبرنا
+
+220
+00:20:17,450 --> 00:20:21,750
+ان البكتيريا في وسط محدود يعني طبق بكتيري زي
+
+221
+00:20:21,750 --> 00:20:26,770
+الصينية يعني وفيها مادة مناسبة لنمو لذا يعني
+
+222
+00:20:26,770 --> 00:20:31,430
+فالبكتيريا مثلا لما صارت الف او الفين او تلات تلات
+
+223
+00:20:32,630 --> 00:20:36,430
+بدأت المواد الغذائي اللي هنا قنضب ايش قنضب يعني
+
+224
+00:20:36,430 --> 00:20:43,210
+قطر قطر اكل فبصير البكتيريا يعني الجديدة مش لاجئة
+
+225
+00:20:43,210 --> 00:20:47,570
+اكل بكموه والبكتيريا الجديدة طالع بدها تغذى ففي
+
+226
+00:20:47,570 --> 00:20:53,270
+توازن بين عدد البكتيريا اللي ينمو او يأتي جديد من
+
+227
+00:20:53,270 --> 00:20:56,870
+القسامهو عدد البكتيريا القديمة اللي بيموت يعني
+
+228
+00:20:56,870 --> 00:21:02,290
+تقريبا الوالد والفاقد جات بعض عشان هيك بيقولوا انه
+
+229
+00:21:02,290 --> 00:21:06,850
+عدد يعني تقريبا ثابت يعني في الطور هذا stationary
+
+230
+00:21:06,850 --> 00:21:13,770
+لا بزيد ولا بخس هذا ليش؟ لأنه طبيعة الوسط بدأ ينضب
+
+231
+00:21:13,770 --> 00:21:17,470
+منه اللي هو المواد الغذائية
+
+232
+00:21:20,390 --> 00:21:24,930
+decline فى ال rate of growth فى نزول فى معدل انه
+
+233
+00:21:24,930 --> 00:21:32,030
+مقابل ال HDD دلوقت وبالتالي يعني بيقوللي انه فى ال
+
+234
+00:21:32,030 --> 00:21:37,530
+medium بيصير ثابت بيصير ثابت يعني الفاقر جد الوالد
+
+235
+00:21:37,530 --> 00:21:42,330
+وبالتالي في stationary phase يعني لو بدأ هذا هنا ب
+
+236
+00:21:42,330 --> 00:21:47,870
+10000 بيضلوا لهنا فترة هذه الوقتية فى 10000
+
+237
+00:21:51,300 --> 00:21:57,220
+مع مرور الوقت بيصير متغيرين المواد الغلائية اللي
+
+238
+00:21:57,220 --> 00:22:01,740
+في الطبق البكتيري تنضج خلاص تنتهيوالاشي التاني
+
+239
+00:22:01,740 --> 00:22:07,260
+اللي هو مخلفات البكتيريا الإخراجية انتوا عارفين
+
+240
+00:22:07,260 --> 00:22:11,180
+يعني زي البني آدم يعني بيأخد طعامه ويله إخراج
+
+241
+00:22:11,180 --> 00:22:14,660
+البكتيريا برضه يلها طعام ويلها إخراج وهذا الإخراج
+
+242
+00:22:14,660 --> 00:22:19,180
+الوسط هذا يقف سد الوسط بيسممه يعني يعني بيصير
+
+243
+00:22:19,180 --> 00:22:25,530
+الوسط هذا وسط قدر وسط مسمم بالنفاياتبتاعة الإخراج
+
+244
+00:22:25,530 --> 00:22:29,670
+البكتيري فبصير وقت مسمّم في هذا الطبخ البكتيري
+
+245
+00:22:29,670 --> 00:22:35,990
+وبالتالي بصير نزول في العدد من عشر تلاف لتسعة تلاف
+
+246
+00:22:35,990 --> 00:22:43,670
+لدمن تلاف لسبعة تلاف لست تلاف لخمس تلاف لاربع تلاف
+
+247
+00:22:43,670 --> 00:22:50,620
+لتلت تلاف لألفين لألف إلى عشرة بعدين سفرهيبقى ال
+
+248
+00:22:50,620 --> 00:22:57,440
+decline يعني الانحضار انه ال rate of death معدن
+
+249
+00:22:57,440 --> 00:23:02,800
+الوفيات يتعدى عدد reproduction الجديد reproduction
+
+250
+00:23:02,800 --> 00:23:06,460
+يعني اللي هو المنتجات البكتيريا الجديدة اللي تيجي
+
+251
+00:23:07,220 --> 00:23:12,300
+الصغيرة وبالتالي ان ال number of dying cells عدد
+
+252
+00:23:12,300 --> 00:23:18,600
+الخلايا الميتة يتعدى عدد الخلايا المتكونة جديدا او
+
+253
+00:23:18,600 --> 00:23:24,880
+اللي هو مولودة جديد وبالتالي بيصير عندنا احنا
+
+254
+00:23:24,880 --> 00:23:30,960
+انحدار والتسمم في الوسط في النهاية كل البكتيريا
+
+255
+00:23:30,960 --> 00:23:37,910
+بتموت وزي ما بدأنا بالصفرهنرجع للصفر وزي ما قال
+
+256
+00:23:37,910 --> 00:23:45,920
+الشائر ما طار طير وارتفع إلا كما طار وقعانا مش حاب
+
+257
+00:23:45,920 --> 00:23:50,400
+اني اطول كتير يعني اتمنى انه هذه المحاضرة تكون
+
+258
+00:23:50,400 --> 00:23:58,440
+اعزبتكم و انه ان شاء الله يكون فيه يعني فايدة و
+
+259
+00:23:58,440 --> 00:24:03,120
+بدي انا يعني اسألكم ان شاء الله في اقرب وقت ان شاء
+
+260
+00:24:03,120 --> 00:24:06,940
+الله على ايش الفايدة اللي انتوا جانتوها من هذا
+
+261
+00:24:06,940 --> 00:24:08,620
+والسلام عليكم ورحمة الله
+
diff --git a/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/b2fCERJL00g_raw.json b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/b2fCERJL00g_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..5cda5cc7e400f2bab0b475ec2af9c65adea56ffd
--- /dev/null
+++ b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/b2fCERJL00g_raw.json
@@ -0,0 +1 @@
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"word": " تققيق", "probability": 0.68798828125}, {"start": 519.36, "end": 519.72, "word": " العيان", "probability": 0.9835611979166666}, {"start": 519.72, "end": 519.88, "word": " في", "probability": 0.72412109375}, {"start": 519.88, "end": 520.5, "word": " بكتيريا", "probability": 0.97978515625}, {"start": 520.5, "end": 521.24, "word": " ووية", "probability": 0.8387044270833334}, {"start": 521.24, "end": 522.06, "word": " كوليرة", "probability": 0.6907552083333334}, {"start": 522.06, "end": 523.1, "word": " وهذه", "probability": 0.920166015625}, {"start": 523.1, "end": 523.18, "word": " ال", "probability": 0.60595703125}, {"start": 523.18, "end": 523.48, "word": " بكتيريا", "probability": 0.92265625}, {"start": 523.48, "end": 523.94, "word": " الووية", "probability": 0.7574462890625}, {"start": 523.94, "end": 524.68, "word": " لو", "probability": 0.96435546875}, {"start": 524.68, "end": 525.1, "word": " وصلت", "probability": 0.7416178385416666}, {"start": 525.1, "end": 525.56, "word": " الميه", "probability": 0.72509765625}, {"start": 525.56, "end": 526.34, "word": " بتعيش", "probability": 0.9246826171875}, {"start": 526.34, "end": 527.34, "word": " اسبوعين", "probability": 0.820556640625}, {"start": 527.34, "end": 527.48, "word": " في", "probability": 0.95263671875}, {"start": 527.48, "end": 527.68, "word": " الميه", "probability": 0.9695638020833334}, {"start": 527.68, "end": 528.18, "word": " الحلوة", "probability": 0.95556640625}], "temperature": 1.0}, {"id": 21, "seek": 55496, "start": 528.74, "end": 554.96, "text": "لعجبة و تمان أسابيع في الماء المالح تمان أسابيع في الماء المالح يبقى لو واحد شرب من المياه هذه على طول بنصاب طيب ماهي طريقة انتشار transmission كيف تنتشر بشرب الماء الملوث و أكل طعام الملوث", "tokens": [1211, 3615, 7435, 49401, 4032, 46811, 7649, 5551, 3794, 16758, 40228, 8978, 9673, 16606, 9673, 6027, 5016, 46811, 7649, 5551, 3794, 16758, 40228, 8978, 9673, 16606, 9673, 6027, 5016, 7251, 3555, 4587, 7578, 45164, 36764, 24401, 13412, 25513, 9154, 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البكتيريا أسهل ليش ال antibiotics اللي يكون عنها effective وموجودة و بتتطور باستمرار ال virus نادر من antivirus وهي الكورونا أغلب العالم ومفيش له antiviral فهذه المقارنة اسمها comparison مقارنة between بكتيريا و ال viruses", "tokens": [3555, 1829, 9381, 13546, 11296, 23032, 5172, 2288, 9307, 2423, 5752, 4724, 1829, 9566, 5172, 2288, 9122, 2655, 13546, 4724, 1829, 9381, 13546, 14407, 23032, 5172, 2288, 9307, 9122, 2655, 48923, 2689, 18863, 1211, 26108, 11203, 26108, 29739, 4117, 2655, 13546, 25528, 5551, 3794, 3224, 1211, 32239, 8592, 2423, 26922, 13672, 1829, 7251, 30544, 18871, 11296, 4942, 4032, 2304, 29245, 23328, 3660, 4032, 39894, 2655, 9566, 13063, 4724, 995, 14851, 29973, 9640, 2423, 5752, 8717, 18513, 2288, 9154, 2511, 592, 9619, 37037, 1829, 33251, 13063, 2407, 8315, 5551, 17082, 46152, 18863, 45340, 4032, 2304, 41185, 8592, 46740, 2511, 592, 35083, 6156, 3224, 24192, 9673, 4587, 9640, 1863, 3660, 24525, 2304, 11296, 9660, 3714, 4587, 9640, 1863, 3660, 1296, 4724, 4117, 2655, 13546, 25528, 4032, 2423, 21785], "avg_logprob": -0.24569389177119638, "compression_ratio": 1.8714859437751004, "no_speech_prob": 0.0, "words": [{"start": 1598.23, "end": 1598.63, "word": "بيصيرها", "probability": 0.6080322265625}, {"start": 1598.63, "end": 1599.19, "word": " طفرات", "probability": 0.908935546875}, {"start": 1599.19, "end": 1600.01, "word": " ال", "probability": 0.6025390625}, {"start": 1600.01, "end": 1600.49, "word": " virus", "probability": 0.2130126953125}, {"start": 1600.49, "end": 1601.05, "word": " بيطفر", "probability": 0.838134765625}, {"start": 1601.05, "end": 1601.47, "word": " كتير", "probability": 0.9186197916666666}, {"start": 1601.47, "end": 1602.01, "word": " بيصيروا", "probability": 0.758056640625}, {"start": 1602.01, "end": 1602.49, "word": " طفرات", "probability": 0.99169921875}, {"start": 1602.49, "end": 1602.93, "word": " كتيرة", "probability": 0.8020833333333334}, {"start": 1602.93, "end": 1603.31, "word": " common", "probability": 0.69677734375}, {"start": 1603.31, "end": 1605.25, "word": " العلاج", "probability": 0.90869140625}, {"start": 1605.25, "end": 1605.47, "word": " علاج", "probability": 0.60906982421875}, {"start": 1605.47, "end": 1605.89, "word": " البكتيريا", "probability": 0.9759765625}, {"start": 1605.89, "end": 1606.27, "word": " أسهل", "probability": 0.92041015625}, {"start": 1606.27, "end": 1606.93, "word": " ليش", "probability": 0.714599609375}, {"start": 1606.93, "end": 1607.87, "word": " ال", "probability": 0.53076171875}, {"start": 1607.87, "end": 1608.31, "word": " antibiotics", "probability": 0.861328125}, {"start": 1608.31, "end": 1608.77, "word": " اللي", "probability": 0.973388671875}, {"start": 1608.77, "end": 1608.91, "word": " يكون", "probability": 0.29443359375}, {"start": 1608.91, "end": 1609.23, "word": " عنها", "probability": 0.886474609375}, {"start": 1609.23, "end": 1609.71, "word": " effective", "probability": 0.77783203125}, {"start": 1609.71, "end": 1610.87, "word": " وموجودة", "probability": 0.856640625}, {"start": 1610.87, "end": 1610.93, "word": " و", "probability": 0.62060546875}, {"start": 1610.93, "end": 1611.47, "word": " بتتطور", "probability": 0.8431396484375}, {"start": 1611.47, "end": 1612.25, "word": " باستمرار", "probability": 0.95703125}, {"start": 1612.25, "end": 1612.85, "word": " ال", "probability": 0.65625}, {"start": 1612.85, "end": 1613.17, "word": " virus", "probability": 0.68310546875}, {"start": 1613.17, "end": 1614.81, "word": " نادر", "probability": 0.8234049479166666}, {"start": 1614.81, "end": 1615.01, "word": " من", "probability": 0.164794921875}, {"start": 1615.01, "end": 1615.69, "word": " antivirus", "probability": 0.8536783854166666}, {"start": 1615.69, "end": 1616.03, "word": " وهي", "probability": 0.811767578125}, {"start": 1616.03, "end": 1616.49, "word": " الكورونا", "probability": 0.8699951171875}, {"start": 1616.49, "end": 1616.85, "word": " أغلب", "probability": 0.8287760416666666}, {"start": 1616.85, "end": 1617.29, "word": " العالم", "probability": 0.995849609375}, {"start": 1617.29, "end": 1618.17, "word": " ومفيش", "probability": 0.8037109375}, {"start": 1618.17, "end": 1618.43, "word": " له", "probability": 0.486083984375}, {"start": 1618.43, "end": 1619.39, "word": " antiviral", "probability": 0.9166666666666666}, {"start": 1619.39, "end": 1619.69, "word": " فهذه", "probability": 0.8792317708333334}, {"start": 1619.69, "end": 1620.27, "word": " المقارنة", "probability": 0.96962890625}, {"start": 1620.27, "end": 1620.57, "word": " اسمها", "probability": 0.8673502604166666}, {"start": 1620.57, "end": 1621.65, "word": " comparison", "probability": 0.9052734375}, {"start": 1621.65, "end": 1623.57, "word": " مقارنة", "probability": 0.892822265625}, {"start": 1623.57, "end": 1624.61, "word": " between", "probability": 0.83349609375}, {"start": 1624.61, "end": 1625.87, "word": " بكتيريا", "probability": 0.89462890625}, {"start": 1625.87, "end": 1626.39, "word": " و", "probability": 0.52490234375}, {"start": 1626.39, "end": 1626.47, "word": " ال", "probability": 0.6357421875}, {"start": 1626.47, "end": 1626.79, "word": " viruses", "probability": 0.7578125}], "temperature": 1.0}, {"id": 63, "seek": 165541, "start": 1627.79, "end": 1655.41, "text": "هنجي في عند ال coronavirus المرة الجاية ان شاء الله يعني هنبدأ في ال coronavirus ويكون ان شاء الله يعني محاضرة يعني كاملة عن ال coronavirus انا يعني اتمنى من الله عز وجل ان تكونوا يعني قد استمتعتم بهذه المحاضرة الرابعة عشرة وما قيل عن تنزيل محاضرات بالتوالي انا هتابع مع الجامعة ان شاء الله والسلام عليكم ورحمة الله", "tokens": [3224, 1863, 7435, 1829, 8978, 43242, 2423, 13043, 9673, 25720, 25724, 995, 10632, 16472, 13412, 16606, 21984, 37495, 22653, 8032, 1863, 44510, 10721, 8978, 2423, 13043, 4032, 1829, 30544, 16472, 13412, 16606, 21984, 37495, 22653, 3714, 5016, 46958, 25720, 37495, 22653, 9122, 10943, 37977, 18871, 2423, 13043, 1975, 8315, 37495, 22653, 1975, 2655, 27842, 7578, 9154, 21984, 6225, 11622, 49610, 1211, 16472, 6055, 30544, 14407, 37495, 22653, 12174, 3215, 44713, 2304, 2655, 34268, 2304, 39627, 24192, 9673, 5016, 46958, 25720, 34892, 16758, 27884, 6225, 8592, 25720, 4032, 15042, 12174, 26895, 18871, 6055, 1863, 11622, 26895, 3714, 5016, 46958, 2288, 9307, 20666, 2655, 2407, 6027, 1829, 1975, 8315, 8032, 2655, 16758, 3615, 20449, 25724, 10943, 27884, 16472, 13412, 16606, 21984, 16070, 3794, 37440, 25894, 24793, 4032, 2288, 35571, 3660, 21984], "avg_logprob": -0.11995192112830969, "compression_ratio": 2.209016393442623, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1627.79, "end": 1628.15, "word": "هنجي", "probability": 0.75}, {"start": 1628.15, "end": 1628.29, "word": " في", "probability": 0.415283203125}, {"start": 1628.29, "end": 1628.45, "word": " عند", "probability": 0.86572265625}, {"start": 1628.45, "end": 1628.57, "word": " ال", "probability": 0.734375}, {"start": 1628.57, "end": 1629.13, "word": " coronavirus", "probability": 0.77099609375}, {"start": 1629.13, "end": 1629.89, "word": " المرة", "probability": 0.9208984375}, {"start": 1629.89, "end": 1630.13, "word": " الجاية", "probability": 0.8050130208333334}, {"start": 1630.13, "end": 1630.29, "word": " ان", "probability": 0.87060546875}, {"start": 1630.29, "end": 1630.41, "word": " شاء", "probability": 0.9853515625}, {"start": 1630.41, "end": 1630.59, "word": " الله", "probability": 0.95263671875}, {"start": 1630.59, "end": 1631.59, "word": " يعني", "probability": 0.840576171875}, {"start": 1631.59, "end": 1632.31, "word": " هنبدأ", "probability": 0.9713134765625}, {"start": 1632.31, "end": 1632.41, "word": " في", "probability": 0.888671875}, {"start": 1632.41, "end": 1632.51, "word": " ال", "probability": 0.8388671875}, {"start": 1632.51, "end": 1633.05, "word": " coronavirus", "probability": 0.94677734375}, {"start": 1633.05, "end": 1633.99, "word": " ويكون", "probability": 0.8082682291666666}, {"start": 1633.99, "end": 1634.15, "word": " ان", "probability": 0.86181640625}, {"start": 1634.15, "end": 1634.31, "word": " شاء", "probability": 0.99462890625}, {"start": 1634.31, "end": 1634.51, "word": " الله", "probability": 0.9638671875}, {"start": 1634.51, "end": 1634.91, "word": " يعني", "probability": 0.8369140625}, {"start": 1634.91, "end": 1636.25, "word": " محاضرة", "probability": 0.984130859375}, {"start": 1636.25, "end": 1637.13, "word": " يعني", "probability": 0.761474609375}, {"start": 1637.13, "end": 1637.81, "word": " كاملة", "probability": 0.99072265625}, {"start": 1637.81, "end": 1638.03, "word": " عن", "probability": 0.99560546875}, {"start": 1638.03, "end": 1638.13, "word": " ال", "probability": 0.8896484375}, {"start": 1638.13, "end": 1638.95, "word": " coronavirus", "probability": 0.95751953125}, {"start": 1638.95, "end": 1640.19, "word": " انا", "probability": 0.85791015625}, {"start": 1640.19, "end": 1640.51, "word": " يعني", "probability": 0.95361328125}, {"start": 1640.51, "end": 1641.09, "word": " اتمنى", "probability": 0.89306640625}, {"start": 1641.09, "end": 1641.19, "word": " من", "probability": 0.96728515625}, {"start": 1641.19, "end": 1641.43, "word": " الله", "probability": 0.95751953125}, {"start": 1641.43, "end": 1641.67, "word": " عز", "probability": 0.9814453125}, {"start": 1641.67, "end": 1642.07, "word": " وجل", "probability": 0.796142578125}, {"start": 1642.07, "end": 1643.29, "word": " ان", "probability": 0.86376953125}, {"start": 1643.29, "end": 1643.99, "word": " تكونوا", "probability": 0.9918619791666666}, {"start": 1643.99, "end": 1644.13, "word": " يعني", "probability": 0.8779296875}, {"start": 1644.13, "end": 1644.41, "word": " قد", "probability": 0.995361328125}, {"start": 1644.41, "end": 1645.09, "word": " استمتعتم", "probability": 0.95302734375}, {"start": 1645.09, "end": 1645.95, "word": " بهذه", "probability": 0.912353515625}, {"start": 1645.95, "end": 1646.47, "word": " المحاضرة", "probability": 0.995849609375}, {"start": 1646.47, "end": 1646.95, "word": " الرابعة", "probability": 0.8486328125}, {"start": 1646.95, "end": 1647.29, "word": " عشرة", "probability": 0.8033040364583334}, {"start": 1647.29, "end": 1648.25, "word": " وما", "probability": 0.94970703125}, {"start": 1648.25, "end": 1648.79, "word": " قيل", "probability": 0.86474609375}, {"start": 1648.79, "end": 1649.23, "word": " عن", "probability": 0.92333984375}, {"start": 1649.23, "end": 1650.09, "word": " تنزيل", "probability": 0.9669189453125}, {"start": 1650.09, "end": 1650.81, "word": " محاضرات", "probability": 0.98408203125}, {"start": 1650.81, "end": 1651.71, "word": " بالتوالي", "probability": 0.670947265625}, {"start": 1651.71, "end": 1651.89, "word": " انا", "probability": 0.931884765625}, {"start": 1651.89, "end": 1652.41, "word": " هتابع", "probability": 0.970458984375}, {"start": 1652.41, "end": 1652.61, "word": " مع", "probability": 0.99560546875}, {"start": 1652.61, "end": 1653.03, "word": " الجامعة", "probability": 0.99169921875}, {"start": 1653.03, "end": 1653.25, "word": " ان", "probability": 0.9228515625}, {"start": 1653.25, "end": 1653.37, "word": " شاء", "probability": 0.993408203125}, {"start": 1653.37, "end": 1653.57, "word": " الله", "probability": 0.951171875}, {"start": 1653.57, "end": 1654.03, "word": " والسلام", "probability": 0.8489583333333334}, {"start": 1654.03, "end": 1654.57, "word": " عليكم", "probability": 0.953857421875}, {"start": 1654.57, "end": 1655.39, "word": " ورحمة", "probability": 0.9576416015625}, {"start": 1655.39, "end": 1655.41, "word": " الله", "probability": 0.90576171875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1656.1865, "duration_after_vad": 1621.2856249999973}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/cCYE9_NHAc8_postprocess.srt b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/cCYE9_NHAc8_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ee4ceb7c32a6f04d13f27ebf65923e1a0a2e5779
--- /dev/null
+++ b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/cCYE9_NHAc8_postprocess.srt
@@ -0,0 +1,696 @@
+1
+00:00:00,000 --> 00:00:04,720
+بسم الله من الشيطان الرجيم بسم الله الرحمن الرحيم
+
+2
+00:00:04,720 --> 00:00:09,380
+الحمد لله و كفا و أصلي و أسلم على النبيين مصطفى
+
+3
+00:00:09,380 --> 00:00:14,640
+بنات الكريمات طبعا انا يعني بحاول ان انا اتقدم في
+
+4
+00:00:14,640 --> 00:00:18,940
+المحاضرات حتى لما انتوا يعني تطلعوا بالسلامة من
+
+5
+00:00:18,940 --> 00:00:23,260
+امتحان النصفي تلاقيوا المحاضرات جاهزة و تستعدوا
+
+6
+00:00:23,260 --> 00:00:27,390
+ليه الامتحان النهائي يعني مافيش وقتيعني انا بعرف
+
+7
+00:00:27,390 --> 00:00:31,750
+ان التحالة نهائي ممكن تكون في 25 او 12 او حواليه
+
+8
+00:00:31,750 --> 00:00:35,610
+يعني فاحنا بدنا نحضر تحالنا يعني مانصرش انه احنا
+
+9
+00:00:35,610 --> 00:00:39,690
+متأخرين تكون الحضارات بين اديكوا ان شاء الله يعني
+
+10
+00:00:39,690 --> 00:00:45,230
+بكل ثلاثة الآن احنا نتكلم على ال infection بتاعة
+
+11
+00:00:45,230 --> 00:00:51,130
+ال eye خاصة البكتيريا ال acanthomoba هذا مش
+
+12
+00:00:51,130 --> 00:00:59,180
+بكتيريا لأهذه يعني نوع من ال Protozoa Protozoa
+
+13
+00:00:59,180 --> 00:01:09,720
+يعني زيها زي الأميبة و زي اللي خدناها الأميبة
+
+14
+00:01:09,720 --> 00:01:15,420
+احنا خدنا ثلاثة منهم منهم أميبة و منهم ايش النوعين
+
+15
+00:01:15,420 --> 00:01:22,510
+التالينالمهم هي هذه زي الأميبة الان
+
+16
+00:01:22,510 --> 00:01:33,550
+هذه نوع من البروتوزوه بتعيش في اللي هو التربة و
+
+17
+00:01:33,550 --> 00:01:36,970
+بتعيش في المياه المالحة brackish water يعني المياه
+
+18
+00:01:36,970 --> 00:01:45,270
+المالحة و بتكون بشكل cyst يعني ايش cyst يعني حواي
+
+19
+00:01:45,270 --> 00:01:50,640
+صينةالحواسنة وهي جواها عايشة عشان تحميها من
+
+20
+00:01:50,640 --> 00:01:57,100
+العوامل الجوية فهي بتكون a cystic form تتحمل
+
+21
+00:01:57,100 --> 00:02:01,420
+resilient للمطايرات الجوية من الحرارة والبرودة
+
+22
+00:02:01,420 --> 00:02:10,580
+والحموضة والكلام هذا الان
+
+23
+00:02:15,640 --> 00:02:21,500
+بقول لي انه تحت العوامل الجوية ممكن
+
+24
+00:02:21,500 --> 00:02:26,020
+لو دخلت مثلا عيل انها تفجس هالي الـ Cyst و تصبح
+
+25
+00:02:26,020 --> 00:02:30,760
+Tropozoite Tropozoite يعني الطور النشط يبقى Cyst
+
+26
+00:02:30,760 --> 00:02:39,660
+الطور المتكيّس خامل Tropozoite الطور النشطوتبدأ
+
+27
+00:02:39,660 --> 00:02:44,120
+تعمل إنزيمات وتدخل في العين في القرنية الخاصة تعمل
+
+28
+00:02:44,120 --> 00:02:47,920
+Penetration و Destruction لنسيج القرنية
+
+29
+00:02:47,920 --> 00:02:53,940
+Destruction لنسيج القرنية يبقى الخطر فيها انها لو
+
+30
+00:02:53,940 --> 00:02:59,620
+دخلت العين Sistولجهة الجو بتاع الاي المناسب ال
+
+31
+00:02:59,620 --> 00:03:02,800
+environment بتاع الاي المناسب انه تبدأ تعمل
+
+32
+00:03:02,800 --> 00:03:10,280
+penetration اختراق وتكسير لنسيج القنانية في الدول
+
+33
+00:03:10,280 --> 00:03:16,320
+المتقدمة او الدول النابية خلنا نقول ال acanthomoba
+
+34
+00:03:16,320 --> 00:03:19,340
+keratitis كيراتيتس يعني انتهاب القنانية بتاع ال
+
+35
+00:03:19,340 --> 00:03:26,320
+acanthomoba الاميبيكثير مرتبط باستعمال العدسات
+
+36
+00:03:26,320 --> 00:03:34,780
+اللاصقة لمدة طويلة خاصة الناس اللي بيطهروا
+
+37
+00:03:34,780 --> 00:03:41,520
+العدسات اللاصقة باستعمال ماء الصنبور ماء
+
+38
+00:03:41,520 --> 00:03:44,000
+الصنبور
+
+39
+00:03:46,560 --> 00:03:50,960
+مش مطهر يعني ممكن يكون فيه اللي هو أميبة أو
+
+40
+00:03:50,960 --> 00:03:56,520
+بكتيريا أو يعني كائنات أخرى لذا هذا احنا بنفهم ان
+
+41
+00:03:56,520 --> 00:04:01,940
+اللي كان ثموبة هو اكتهاب قرني سببه مش بكتيري بروتو
+
+42
+00:04:01,940 --> 00:04:14,370
+زوة بروتو زوة بروتو زوةالان الصورة تتكلم عن الـ
+
+43
+00:04:14,370 --> 00:04:17,890
+Cist في
+
+44
+00:04:17,890 --> 00:04:21,210
+القرنية
+
+45
+00:04:21,210 --> 00:04:24,250
+الـ Cist في القرنية
+
+46
+00:04:27,110 --> 00:04:32,830
+بدت تعمل Epithelial Involvement يعني بدت تلهد
+
+47
+00:04:32,830 --> 00:04:37,210
+الابيثريام على الطبقة الطلائية بتاعت القرنية
+
+48
+00:04:37,210 --> 00:04:42,850
+السطحية بعد هي خشينا في C بدت تدخش على Stroma
+
+49
+00:04:42,850 --> 00:04:51,410
+الطبقة اللي بعد الابيثريام اسمها Stromaو يعني هنا
+
+50
+00:04:51,410 --> 00:04:58,590
+يعني بعد هيك في ال D صارت radial perineuritis
+
+51
+00:04:58,590 --> 00:05:06,050
+شايفين كيف يعني هنا كيف التهاب الأعصاب المغزية
+
+52
+00:05:06,050 --> 00:05:13,470
+القرنيةعندما تتطور
+
+53
+00:05:13,470 --> 00:05:17,770
+و تصبح اكانترموبا اكانترموبا اكانترموبا اكانترموبا
+
+54
+00:05:17,770 --> 00:05:21,150
+اكانترموبا اكانترموبا اكانترموبا اكانترموبا
+
+55
+00:05:21,150 --> 00:05:21,490
+اكانترموبا اكانترموبا اكانترموبا اكانترموبا
+
+56
+00:05:21,490 --> 00:05:25,510
+اكانترموبا اكانترموبا اكانترموبا اكانترموبا
+
+57
+00:05:25,510 --> 00:05:25,650
+اكانترموبا اكانترموبا اكانترموبا اكانترموبا
+
+58
+00:05:25,650 --> 00:05:25,810
+اكانترموبا اكانترموبا اكانترموبا اكانترموبا
+
+59
+00:05:25,810 --> 00:05:29,450
+اكانترموبا
+
+60
+00:05:29,450 --> 00:05:37,690
+اكانترموبا اكانتربعد ذلك بدأت تعمل ring abscess في
+
+61
+00:05:37,690 --> 00:05:41,590
+بي هذا بي اسمه ring abscess حلقي
+
+62
+00:05:44,790 --> 00:05:50,710
+الأبسس الحلقى يعني الدُمّال أبسس يعني دُمّال ثم في
+
+63
+00:05:50,710 --> 00:05:56,310
+الـC أو أسف في ال .. في ال .. في ال .. هذا الحلقى
+
+64
+00:05:56,310 --> 00:06:02,610
+في الـB الحلقى هذا في الـB أما الـC فهو melting
+
+65
+00:06:02,610 --> 00:06:07,430
+يعني دوبان النسيج القرنية melting دوبان ولمّا
+
+66
+00:06:07,430 --> 00:06:10,850
+القرنية تدوب بعد هيك بصير اختراق وتدخل جوا
+
+67
+00:06:10,850 --> 00:06:15,760
+الـanterior chamberكانت موبا حقيقة احنا جربنا في
+
+68
+00:06:15,760 --> 00:06:23,100
+علاجها صعب جدا يعني فارق انا اعالج ال amoeba زي
+
+69
+00:06:23,100 --> 00:06:27,060
+انت amoeba histerotica في بطن الإنسان في الأمعاء
+
+70
+00:06:27,060 --> 00:06:32,140
+واني اعالجها في القرنية القرنية يعني هذه يعني
+
+71
+00:06:32,140 --> 00:06:40,510
+طبقات شفافةيعني المرض فيها ممكن يؤدي الى اعتامها و
+
+72
+00:06:40,510 --> 00:06:44,210
+الى فقد البصر وبالتالي لو القنانية صابها
+
+73
+00:06:44,210 --> 00:06:49,190
+أكانثوموبا علاجها صعب جدا وغالبا العين هذه هتصير
+
+74
+00:06:49,190 --> 00:06:55,770
+عمياء ويمكن تكون مرشحة لنقل قنانية إذا كان تيأسر
+
+75
+00:06:55,770 --> 00:06:57,710
+الأمر في بلد متقدم
+
+76
+00:07:00,030 --> 00:07:04,710
+طيب الآن في موضوع اسمه marginal keratitis التهاب
+
+77
+00:07:04,710 --> 00:07:11,850
+القرنية الطرفي يعني هذه القرنية هيك فيه التهاب على
+
+78
+00:07:11,850 --> 00:07:16,970
+الحد يعني من
+
+79
+00:07:16,970 --> 00:07:21,370
+داخل اللي هو محيط القرنية من داخل محيط الـ
+
+80
+00:07:21,370 --> 00:07:24,930
+periphery of Guam لما ال marginal keratitis الحد
+
+81
+00:07:24,930 --> 00:07:34,030
+فيهغالبا هو عبارة عن hypersensitivity لإكزوتوكسين
+
+82
+00:07:34,030 --> 00:07:38,270
+كستفل الكوكاية احنا خدنا كستفل كوكاية خاصة اورياس
+
+83
+00:07:38,270 --> 00:07:44,750
+العديد من سموم الاكزوتوكسين والاندوتوكسين فلو اجت
+
+84
+00:07:44,750 --> 00:07:50,610
+بكتيريا ودخلت على سطح القرنية تبدأ هذه البكتيريا
+
+85
+00:07:50,610 --> 00:07:52,470
+تفرز سموم
+
+86
+00:07:55,430 --> 00:08:01,070
+السوم هذه بيصيب لها استجابة منارية immune response
+
+87
+00:08:01,070 --> 00:08:06,470
+immune response للسوم هذه في شكل Deposition
+
+88
+00:08:06,470 --> 00:08:12,490
+Deposition يعني شكل ترسبات
+
+89
+00:08:12,490 --> 00:08:21,950
+على داخل محيط القرنية داخل محيط القرنيةوبالتالي
+
+90
+00:08:21,950 --> 00:08:25,370
+هذا الـ Deposition هو عبارة عن Antigen-Antibody
+
+91
+00:08:25,370 --> 00:08:30,930
+reaction استجابة منعية يعني التوكسينات هذه اللي
+
+92
+00:08:30,930 --> 00:08:36,910
+حطتها البكتيريا للجسم من الدم أو من الـ Tear Film
+
+93
+00:08:36,910 --> 00:08:43,880
+طلع لهاIGA IGA اللي أخدناه احنا Immunoglobulin A
+
+94
+00:08:43,880 --> 00:08:50,220
+عشان تتحد مع السوم هذه وخفف أثرها على إذاء
+
+95
+00:08:50,220 --> 00:08:54,560
+القنانية وبالتالي Antigen Antibody Complex A
+
+96
+00:08:54,560 --> 00:08:57,940
+reactionary complex في محيط القنانية
+
+97
+00:09:01,060 --> 00:09:06,620
+قد يؤدي إلى هذه الترثبات وهي عبارة عن يعني
+
+98
+00:09:06,620 --> 00:09:11,060
+secondary lymphocytic infiltration لصورة يعني
+
+99
+00:09:11,060 --> 00:09:17,080
+خلايا منعية lymphocytes ومع ال complex ال complex
+
+100
+00:09:17,080 --> 00:09:20,140
+يعني ال complex بتاع ال antigen و ال antibody و مع
+
+101
+00:09:20,140 --> 00:09:24,020
+ال lymphocytes ال lymphocytes اللي ترثبت في
+
+102
+00:09:24,020 --> 00:09:28,850
+المفاتيح القرانية لو اجينا احنا نعمل مزرعةقد لا
+
+103
+00:09:28,850 --> 00:09:32,990
+نجد Staphylococcus aureus لكن ممكن بالفحص انه
+
+104
+00:09:32,990 --> 00:09:37,750
+نلاقي legs of toxins هذه العملية ما بقدر اقول انها
+
+105
+00:09:37,750 --> 00:09:42,250
+ضاربة القرانية الاتنين لان الجزء ال central part
+
+106
+00:09:42,250 --> 00:09:48,380
+من القرانية clear بزاية كان في موبا تاخد النصأو
+
+107
+00:09:48,380 --> 00:09:52,420
+جزء المركزي المصادر لأ هذا الـ central clear
+
+108
+00:09:52,420 --> 00:09:57,580
+وبالتالي ممكن ان الـ periphery هذا اللي يعني من
+
+109
+00:09:57,580 --> 00:10:03,960
+داخل المحيط انه مايأثرش كتير على بصر المصادر يعني
+
+110
+00:10:03,960 --> 00:10:07,440
+انا بقدر اقول هىالـ Marginal infiltrates هنا هيها
+
+111
+00:10:07,440 --> 00:10:15,420
+وبعدين يعني في C هيها بحيث القرنية عليه يعني هذه
+
+112
+00:10:15,420 --> 00:10:20,440
+التراثبات البيضاء اه Antibody reactional exotoxins
+
+113
+00:10:20,440 --> 00:10:25,520
+of staphylococcus aureus بكتيريا يعني هنا في
+
+114
+00:10:25,520 --> 00:10:29,300
+التشخيص احنا بنعرف ان في بكتيريا هناوممكن لو كان
+
+115
+00:10:29,300 --> 00:10:33,400
+هناك شكوى اننا نعالجها لكن الـ Central part الحمد
+
+116
+00:10:33,400 --> 00:10:40,460
+لله بيكون Clear وما بتأثرش كثير اه و احنا هذا فيما
+
+117
+00:10:40,460 --> 00:10:47,520
+بعد سميه Panas اللي هو تبدأ يعني من المسكحمة تدخل
+
+118
+00:10:47,520 --> 00:10:53,380
+بعض الأوية الدموية هيها الى محطة قرنية لتغذية يعني
+
+119
+00:10:53,380 --> 00:10:58,260
+ال deposits هذه Panas اسمها Panasيعني احنا لعين
+
+120
+00:10:58,260 --> 00:11:04,100
+بالهنجوم مش خطيرة وما بتأثرش على البصر كثيرا طيب
+
+121
+00:11:04,100 --> 00:11:10,780
+الان هنتكلم على نوع من ال keratopathy اللي هو مرض
+
+122
+00:11:10,780 --> 00:11:15,740
+القنانية بقوله infectious crystalline keratopathy
+
+123
+00:11:15,740 --> 00:11:21,600
+حقيقة ان هذا يعني في الناس اللي باخدوا topical
+
+124
+00:11:21,600 --> 00:11:26,970
+steroid لمدة طويلةالثيرويد يعني اللي هو قطرات
+
+125
+00:11:26,970 --> 00:11:31,590
+الكورتزون معروف انه احنا قطرات الكورتزون بنرجع
+
+126
+00:11:31,590 --> 00:11:36,520
+اليها بعد عمليات جراحية داخل العينناخدها ممكن
+
+127
+00:11:36,520 --> 00:11:42,360
+أسبوع أو شهور ممكن في التهيبات ال .. ال .. ال ..
+
+128
+00:11:42,360 --> 00:11:49,180
+ال iris و ال celery body برضه ممكن جدا ناخد
+
+129
+00:11:49,180 --> 00:11:54,540
+كورتيزون لمدة طويلة و في ناس ماخدوها في اللي هو ال
+
+130
+00:11:54,540 --> 00:12:00,360
+allergic contractivitis لما تكون شريدة زييعني
+
+131
+00:12:00,360 --> 00:12:08,340
+موضوع اللي هو الحسية الصيفية Vernal Keratopathy
+
+132
+00:12:08,340 --> 00:12:13,340
+Vernal يعني المرض Vernal اللي هو Spring Catara زي
+
+133
+00:12:13,340 --> 00:12:19,100
+اللي هو حسية الربيع فبقول لي ان كتر الكورتيزون هذا
+
+134
+00:12:19,100 --> 00:12:26,320
+long term لمدة طويلة بيعمللي keratopathy يعني
+
+135
+00:12:26,320 --> 00:12:27,740
+اعتلال القرنية
+
+136
+00:12:30,420 --> 00:12:37,000
+القرنية بنتج عنه defect ابثيريا مش متواطل فيه
+
+137
+00:12:37,000 --> 00:12:42,360
+تقطعات في غياب لبعض مناطق الابثيريا عن سطح القرنية
+
+138
+00:12:44,580 --> 00:12:53,000
+وبقول ان البكتيريا بتستغل هذا النقص خاصة بعد عملية
+
+139
+00:12:53,000 --> 00:12:56,000
+تقيق القرانية أو نقل القرانية Penetrating
+
+140
+00:12:56,000 --> 00:13:00,320
+keratoplasty هي نقل القرانية كاملا يعني لما
+
+141
+00:13:00,320 --> 00:13:04,360
+القرانية تكون تلفانة بينقل من 100
+
+142
+00:13:07,270 --> 00:13:13,150
+للانسان الحي اللى قناته خربانة بنقوله اللى هو
+
+143
+00:13:13,150 --> 00:13:17,110
+القرانية بقول عنها keratoplasty penetrating أي
+
+144
+00:13:17,110 --> 00:13:21,270
+كامر الطبقات بكل طبقاتها لأن في شئ اسمه لملة
+
+145
+00:13:21,270 --> 00:13:25,090
+كيراتو بلاستي اللى هو يعني بعض الطبقات لكن
+
+146
+00:13:25,090 --> 00:13:29,630
+penetrating كلها فبقول ليه انه لما أنجل القرانية
+
+147
+00:13:29,630 --> 00:13:33,750
+من ميت إلى حي ممكن وبعطيه كورتازون لمدة ست شهور
+
+148
+00:13:33,750 --> 00:13:38,580
+بالقليلممكن جدا ان الكورتزون يعمل effect
+
+149
+00:13:38,580 --> 00:13:43,620
+للابيثيليام وبالتالي تدخل بكتيريا زي streptococcus
+
+150
+00:13:43,620 --> 00:13:50,280
+viridans ان نجيها داخل الابيثيليام هذا و تعمل
+
+151
+00:13:50,280 --> 00:13:56,370
+كيراتو buffingممكن بيقول يعني ممكن بكتيريا غيرها
+
+152
+00:13:56,370 --> 00:14:00,350
+يدخل، ممكن فانجايا يدخل، لأن طالما ان الابيثيليام
+
+153
+00:14:00,350 --> 00:14:05,210
+صار له defect، يعني من هنا مثلا إلى هنا defect،
+
+154
+00:14:05,210 --> 00:14:13,510
+ممكن جدا ان طبخات القنية الأخرى يدخلها
+
+155
+00:14:13,510 --> 00:14:19,760
+بكتيريا، لأن الباب صار مفتوحفهذا في حالة نقل
+
+156
+00:14:19,760 --> 00:14:23,640
+القرمية واخد كورتزون لمدة طويلة جدا يعني ممكن تكون
+
+157
+00:14:23,640 --> 00:14:28,960
+في infectious crystalline keratopatin هاي الصورة
+
+158
+00:14:28,960 --> 00:14:33,160
+في ايه اللي هو هايو infectious crystalline
+
+159
+00:14:33,160 --> 00:14:36,180
+keratitis في التاني crystalline keratitis in the
+
+160
+00:14:36,180 --> 00:14:41,370
+graftيعني القرانية التي نقلناها من الميت إلى الحي
+
+161
+00:14:41,370 --> 00:14:46,490
+وهذا صابها كراكو باسي واضح انه صارت معتمة وابتدت
+
+162
+00:14:46,490 --> 00:14:54,810
+تصير ايش يعني clear او transparent الغرز هذه ال
+
+163
+00:14:54,810 --> 00:15:00,730
+continuous اسمها sewers هذه بنحطها عشان نثبت
+
+164
+00:15:00,730 --> 00:15:04,890
+القرانية بتاعت اللي هو جديدة ان انتقلت في مكانها
+
+165
+00:15:04,890 --> 00:15:13,220
+في 360 درجةتلاقين ورد هالك كيف هي ليه هيك طيب الان
+
+166
+00:15:13,220 --> 00:15:19,340
+يعني يعني
+
+167
+00:15:19,340 --> 00:15:24,680
+انا اود حقيقة ان اتوقفعند بداية الموضوع الأهم فيما
+
+168
+00:15:24,680 --> 00:15:28,220
+أخدنا ال bacteria keratitis لأن ال bacteria
+
+169
+00:15:28,220 --> 00:15:32,260
+keratitis فعلا يعني ممكن تؤدي للعمق وهي واسعة في
+
+170
+00:15:32,260 --> 00:15:36,460
+انتشاره موجودة فانا حابب ان انا اتوقف ان الموضوع
+
+171
+00:15:36,460 --> 00:15:40,600
+هذا و اكمل في المحاضرة رابع و عشرين ان شاء الله
+
+172
+00:15:40,600 --> 00:15:44,460
+تكونوا يعني الوضع صار عندك واضحوأسأل الله إن ربنا
+
+173
+00:15:44,460 --> 00:15:47,920
+يعني يبارك فيها الجهود وإنه يجعل فيها الفائدة يا
+
+174
+00:15:47,920 --> 00:15:52,220
+رب وأقول قولي هذا وأستغفر الله
+
diff --git a/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/hLRzgFpK7kg_raw.json b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/hLRzgFpK7kg_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..fd5e9b12477debee7ac4d13f5e7b3bf76c50abcd
--- /dev/null
+++ b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/hLRzgFpK7kg_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2771, "start": 0.25, "end": 27.71, "text": "أعوذ بالله من الشيطان الرجيم بسم الله الرحمن الرحيم الحمد لله وكفاه وأصلي و أسلم على النبي المصطفى أما بعد السلام عليكم ورحمة الله وبركاته أعوذ ولكم في هذه المحاضرة العشرين لأكمل دور اللي هو العين في الدفاع أو الدفاعات في عين الإنسان خاصة ال tear film", "tokens": [10721, 3615, 2407, 8848, 20666, 43761, 9154, 25124, 1829, 9566, 7649, 34892, 7435, 32640, 4724, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 21542, 2304, 3215, 24976, 3224, 4032, 4117, 5172, 995, 3224, 36725, 9381, 20292, 4032, 5551, 3794, 19528, 15844, 28239, 21292, 9673, 9381, 9566, 5172, 7578, 5551, 15042, 39182, 21136, 37440, 25894, 24793, 4032, 2288, 35571, 3660, 21984, 4032, 26890, 4117, 9307, 3224, 5551, 3615, 2407, 8848, 35525, 24793, 8978, 29538, 9673, 5016, 46958, 25720, 18863, 46309, 9957, 5296, 10721, 24793, 1211, 11778, 13063, 13672, 1829, 31439, 18863, 9957, 8978, 32748, 5172, 45761, 34051, 32748, 5172, 45761, 9307, 8978, 6225, 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{"start": 1204.15, "end": 1204.47, "word": " من", "probability": 0.98876953125}, {"start": 1204.47, "end": 1204.71, "word": " ال", "probability": 0.94873046875}, {"start": 1204.71, "end": 1205.03, "word": " aids", "probability": 0.67431640625}, {"start": 1205.03, "end": 1205.87, "word": " برضه", "probability": 0.98974609375}, {"start": 1205.87, "end": 1206.41, "word": " بتزيد", "probability": 0.9547526041666666}, {"start": 1206.41, "end": 1207.01, "word": " عندهم", "probability": 0.98974609375}, {"start": 1207.01, "end": 1207.61, "word": " اللي", "probability": 0.9345703125}, {"start": 1207.61, "end": 1207.93, "word": " هو", "probability": 0.9658203125}, {"start": 1207.93, "end": 1209.01, "word": " البكتيريا", "probability": 0.97431640625}, {"start": 1209.01, "end": 1210.27, "word": " المرضية", "probability": 0.9947916666666666}], "temperature": 1.0}, {"id": 49, "seek": 122442, "start": 1212.8, "end": 1224.42, "text": "يقول لي انه مدى اللي هو تأثير البكتيريا المرضى اه وقدرتها على احداث المرض cause disease", "tokens": [1829, 39648, 32239, 16472, 3224, 3714, 3215, 7578, 13672, 1829, 31439, 6055, 10721, 12984, 13546, 29739, 4117, 2655, 13546, 25528, 9673, 43042, 7578, 1975, 3224, 4032, 28543, 43500, 11296, 15844, 1975, 24401, 5718, 104, 9673, 43042, 3082, 4752], "avg_logprob": -0.2433894238410852, "compression_ratio": 1.3243243243243243, "no_speech_prob": 0.0, "words": [{"start": 1212.8, "end": 1213.24, "word": "يقول", "probability": 0.649658203125}, {"start": 1213.24, "end": 1213.5, "word": " لي", "probability": 0.5791015625}, {"start": 1213.5, "end": 1214.34, "word": " انه", "probability": 0.525146484375}, {"start": 1214.34, "end": 1217.16, "word": " مدى", "probability": 0.8063151041666666}, {"start": 1217.16, "end": 1218.38, "word": " اللي", "probability": 0.795166015625}, {"start": 1218.38, "end": 1218.78, "word": " هو", "probability": 0.9892578125}, {"start": 1218.78, "end": 1219.44, "word": " تأثير", "probability": 0.9951171875}, {"start": 1219.44, "end": 1220.1, 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لو قولنا كيف يعني البكتيريا المرضية يعني بتعتمد على العوام الهادي مثلا البكتيريا ال virulence", "tokens": [3555, 36081, 9566, 46152, 16490, 2304, 3794, 11331, 26108, 9307, 1975, 2407, 39894, 34268, 2304, 3215, 15844, 16490, 2304, 3794, 11331, 26108, 9307, 2423, 4107, 425, 655, 25124, 2288, 32277, 3660, 2423, 16199, 21542, 31747, 3660, 2423, 614, 8076, 8477, 16712, 3794, 995, 4587, 2423, 1048, 296, 8477, 13672, 1829, 31439, 18863, 3215, 2407, 7649, 10632, 18863, 3215, 2407, 7649, 10632, 4032, 3248, 299, 2310, 16712, 4117, 9307, 2288, 23032, 3555, 3615, 995, 1975, 5016, 8315, 45164, 12174, 12610, 8315, 9122, 33911, 37495, 22653, 29739, 4117, 2655, 13546, 25528, 9673, 43042, 10632, 37495, 22653, 39894, 34268, 2304, 3215, 15844, 18863, 2407, 10943, 2423, 11296, 16254, 50113, 15040, 29739, 4117, 2655, 13546, 25528, 2423, 4107, 425, 655], "avg_logprob": -0.20886751983919713, "compression_ratio": 1.909871244635193, "no_speech_prob": 0.0, "words": [{"start": 1225.55, "end": 1226.59, "word": 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"probability": 0.927734375}, {"start": 1241.43, "end": 1242.95, "word": " replicability", "probability": 0.7737630208333334}, {"start": 1242.95, "end": 1244.03, "word": " التكاتر", "probability": 0.8897705078125}, {"start": 1244.03, "end": 1245.01, "word": " طبعا", "probability": 0.983154296875}, {"start": 1245.01, "end": 1245.21, "word": " احنا", "probability": 0.9593098958333334}, {"start": 1245.21, "end": 1245.33, "word": " لو", "probability": 0.96533203125}, {"start": 1245.33, "end": 1245.85, "word": " قولنا", "probability": 0.6200358072916666}, {"start": 1245.85, "end": 1246.89, "word": " كيف", "probability": 0.966064453125}, {"start": 1246.89, "end": 1247.09, "word": " يعني", "probability": 0.957275390625}, {"start": 1247.09, "end": 1247.69, "word": " البكتيريا", "probability": 0.96083984375}, {"start": 1247.69, "end": 1249.07, "word": " المرضية", "probability": 0.986328125}, {"start": 1249.07, "end": 1249.75, "word": " يعني", "probability": 0.7685546875}, {"start": 1249.75, "end": 1250.27, "word": " بتعتمد", "probability": 0.967041015625}, {"start": 1250.27, "end": 1250.53, "word": " على", "probability": 0.90625}, {"start": 1250.53, "end": 1251.05, "word": " العوام", "probability": 0.9547526041666666}, {"start": 1251.05, "end": 1251.31, "word": " الهادي", "probability": 0.6668294270833334}, {"start": 1251.31, "end": 1251.69, "word": " مثلا", "probability": 0.941162109375}, {"start": 1251.69, "end": 1252.87, "word": " البكتيريا", "probability": 0.885986328125}, {"start": 1252.87, "end": 1252.99, "word": " ال", "probability": 0.9296875}, {"start": 1252.99, "end": 1253.45, "word": " virulence", "probability": 0.7762044270833334}], "temperature": 1.0}, {"id": 51, "seek": 125609, "start": 1254.5, "end": 1256.1, "text": "أكتر قدرة على تخييف المرض", "tokens": [10721, 4117, 2655, 2288, 12174, 3215, 25720, 15844, 6055, 9778, 1829, 33911, 9673, 43042], "avg_logprob": -0.24244791666666668, "compression_ratio": 0.8846153846153846, "no_speech_prob": 0.0, "words": [{"start": 1254.5, "end": 1255.0, "word": "أكتر", "probability": 0.7615966796875}, {"start": 1255.0, "end": 1255.28, "word": " قدرة", "probability": 0.93798828125}, {"start": 1255.28, "end": 1255.42, "word": " على", "probability": 0.90185546875}, {"start": 1255.42, "end": 1255.82, "word": " تخييف", "probability": 0.70458984375}, {"start": 1255.82, "end": 1256.1, "word": " المرض", "probability": 0.98974609375}], "temperature": 1.0}, {"id": 52, "seek": 128504, "start": 1256.9, "end": 1285.04, "text": "والبكتيريا المتحركة اللي لها أقسام كتيرة أكتر قدرة على إحداث المرض و ال adhesiveness انه قدرة الاتصاق اللي لها سيريا كتير سيريا فشعيرات ثاصقة بتزيد و العدوانية في بكتيريا يعني أكتر عدوانية و قدرة على اختراق برضه تؤثر في المرض و reflectibility قدرتها على التكاتر كل ما زاد اللي هو سرعة التكاتر", "tokens": [2407, 6027, 3555, 4117, 2655, 13546, 25528, 9673, 2655, 5016, 31747, 3660, 13672, 1829, 5296, 11296, 5551, 4587, 3794, 10943, 9122, 2655, 48923, 5551, 4117, 2655, 2288, 12174, 3215, 25720, 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{"id": 62, "seek": 152273, "start": 1508.17, "end": 1522.73, "text": "طيب هنخلص ان شاء الله packers of ocular infection ما هي انما العدوى العيق في العين عدوى البكتيريا في العين بقوللي ان العدوى البكتيريا في العين", "tokens": [9566, 1829, 3555, 8032, 1863, 9778, 1211, 9381, 16472, 13412, 16606, 21984, 2844, 433, 295, 10409, 1040, 11764, 19446, 39896, 16472, 15042, 18863, 3215, 2407, 7578, 18863, 1829, 4587, 8978, 18863, 9957, 6225, 3215, 2407, 7578, 29739, 4117, 2655, 13546, 25528, 8978, 18863, 9957, 4724, 39648, 20292, 16472, 18863, 3215, 2407, 7578, 29739, 4117, 2655, 13546, 25528, 8978, 18863, 9957], "avg_logprob": -0.22233605873389323, "compression_ratio": 1.7028985507246377, "no_speech_prob": 0.0, "words": [{"start": 1508.17, "end": 1508.75, "word": "طيب", "probability": 0.8509114583333334}, {"start": 1508.75, "end": 1510.55, "word": " هنخلص", "probability": 0.92607421875}, {"start": 1510.55, "end": 1510.73, "word": " ان", "probability": 0.096435546875}, {"start": 1510.73, "end": 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عندنا anatomic barriers و anatomic location اللي قلنا عنها جاب شوية القرنية و المفتحمة Muskula هذه اسمها natural anatomic barriers يعني لو ان مافيش natural anatomic barriers ده كان زمان كل عينينا دخلت فيها بكتيريا من زمان و فيروسات", "tokens": [2304, 8592, 8608, 3224, 1211, 3660, 5296, 33456, 43242, 8315, 21618, 21401, 13565, 4032, 21618, 21401, 4914, 13672, 1829, 12174, 1211, 8315, 18871, 11296, 10874, 16758, 13412, 2407, 10632, 25062, 2288, 1863, 10632, 4032, 9673, 5172, 2655, 35571, 3660, 26019, 3780, 29538, 24525, 2304, 11296, 3303, 21618, 21401, 13565, 37495, 22653, 45164, 16472, 19446, 41185, 8592, 3303, 21618, 21401, 13565, 11778, 3224, 25961, 30767, 2304, 7649, 28242, 6225, 9957, 1829, 8315, 11778, 9778, 1211, 2655, 8978, 11296, 4724, 4117, 2655, 13546, 25528, 9154, 30767, 2304, 7649, 4032, 8978, 32887, 3794, 9307], "avg_logprob": -0.32319973571145016, "compression_ratio": 1.6981132075471699, "no_speech_prob": 0.0, "words": [{"start": 1523.84, "end": 1524.24, "word": "مش", 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1558.1, "word": " سكريرة", "probability": 0.707611083984375}, {"start": 1558.1, "end": 1559.4, "word": " تمنع", "probability": 0.8653971354166666}, {"start": 1559.4, "end": 1560.0, "word": " الدخول", "probability": 0.9947916666666666}], "temperature": 1.0}, {"id": 65, "seek": 158791, "start": 1561.25, "end": 1587.91, "text": "responsible for مسئول عن انه تخلي البكتيريا superficial keeping superficial infection يعني على السطح الخارجي ممنوع تدخل جوا و تخلي داخل العين internal contents اللي هو يعني ال antero chamber و ال lens و ال petrius تخليه sterile معطم ممنوع يدخله اي بكتيريا لانه يدخل اندوستيلميتس و يخرب العين", "tokens": [28930, 964, 337, 47524, 19986, 12610, 18871, 16472, 3224, 6055, 9778, 20292, 29739, 4117, 2655, 13546, 25528, 34622, 5145, 34622, 11764, 37495, 22653, 15844, 21136, 9566, 5016, 33962, 9640, 7435, 1829, 3714, 27842, 45367, 6055, 3215, 9778, 1211, 10874, 14407, 4032, 6055, 9778, 20292, 11778, 47283, 1211, 18863, 9957, 6920, 15768, 13672, 1829, 31439, 37495, 22653, 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"end": 1567.29, "word": " البكتيريا", "probability": 0.94931640625}, {"start": 1567.29, "end": 1567.61, "word": " superficial", "probability": 0.5849609375}, {"start": 1567.61, "end": 1568.77, "word": " keeping", "probability": 0.256103515625}, {"start": 1568.77, "end": 1569.43, "word": " superficial", "probability": 0.92626953125}, {"start": 1569.43, "end": 1569.97, "word": " infection", "probability": 0.84326171875}, {"start": 1569.97, "end": 1570.85, "word": " يعني", "probability": 0.92529296875}, {"start": 1570.85, "end": 1570.99, "word": " على", "probability": 0.66357421875}, {"start": 1570.99, "end": 1571.33, "word": " السطح", "probability": 0.9544270833333334}, {"start": 1571.33, "end": 1572.23, "word": " الخارجي", "probability": 0.8006591796875}, {"start": 1572.23, "end": 1572.57, "word": " ممنوع", "probability": 0.8878580729166666}, {"start": 1572.57, "end": 1572.89, "word": " تدخل", "probability": 0.9913330078125}, {"start": 1572.89, "end": 1573.21, "word": " جوا", "probability": 0.64501953125}, {"start": 1573.21, "end": 1573.79, "word": " و", "probability": 0.35107421875}, {"start": 1573.79, "end": 1574.25, "word": " تخلي", "probability": 0.8583984375}, {"start": 1574.25, "end": 1574.75, "word": " داخل", "probability": 0.9765625}, {"start": 1574.75, "end": 1575.19, "word": " العين", "probability": 0.976318359375}, {"start": 1575.19, "end": 1576.25, "word": " internal", "probability": 0.6435546875}, {"start": 1576.25, "end": 1577.51, "word": " contents", "probability": 0.9375}, {"start": 1577.51, "end": 1578.13, "word": " اللي", "probability": 0.87890625}, {"start": 1578.13, "end": 1578.33, "word": " هو", "probability": 0.931640625}, {"start": 1578.33, "end": 1578.47, "word": " يعني", "probability": 0.65185546875}, {"start": 1578.47, "end": 1578.57, "word": " ال", "probability": 0.96435546875}, {"start": 1578.57, "end": 1578.91, "word": " antero", "probability": 0.4911295572916667}, {"start": 1578.91, "end": 1579.31, "word": " chamber", "probability": 0.92822265625}, {"start": 1579.31, "end": 1579.49, "word": " و", "probability": 0.4921875}, {"start": 1579.49, "end": 1579.73, "word": " ال", "probability": 0.625}, {"start": 1579.73, "end": 1580.71, "word": " lens", "probability": 0.1248779296875}, {"start": 1580.71, "end": 1581.31, "word": " و", "probability": 0.65234375}, {"start": 1581.31, "end": 1581.41, "word": " ال", "probability": 0.76123046875}, {"start": 1581.41, "end": 1581.85, "word": " petrius", "probability": 0.512939453125}, {"start": 1581.85, "end": 1582.31, "word": " تخليه", "probability": 0.8414306640625}, {"start": 1582.31, "end": 1582.93, "word": " sterile", "probability": 0.7225341796875}, {"start": 1582.93, "end": 1583.59, "word": " معطم", "probability": 0.7228190104166666}, {"start": 1583.59, "end": 1584.11, "word": " ممنوع", "probability": 0.9736328125}, {"start": 1584.11, "end": 1584.53, "word": " يدخله", "probability": 0.869140625}, {"start": 1584.53, "end": 1584.75, "word": " اي", "probability": 0.691650390625}, {"start": 1584.75, "end": 1585.31, "word": " بكتيريا", "probability": 0.9890625}, {"start": 1585.31, "end": 1585.89, "word": " لانه", "probability": 0.6581217447916666}, {"start": 1585.89, "end": 1586.13, "word": " يدخل", "probability": 0.79473876953125}, {"start": 1586.13, "end": 1587.19, "word": " اندوستيلميتس", "probability": 0.55267333984375}, {"start": 1587.19, "end": 1587.27, "word": " و", "probability": 0.65185546875}, {"start": 1587.27, "end": 1587.59, "word": " يخرب", "probability": 0.6588541666666666}, {"start": 1587.59, "end": 1587.91, "word": " العين", "probability": 0.9892578125}], "temperature": 1.0}, {"id": 66, "seek": 161075, "start": 1588.19, "end": 1610.75, "text": "يبقى مفائدة الانتوبيك باريارز هنا ان تخلي البكتيريا على السطح وان تسمحش تدخل الداخل لكي تفضل الاسترال هيك احنا دخلنا او خلصنا المحاضرة العشرين وانا اسأل الله سبحانه وتعالى", "tokens": [1829, 3555, 4587, 7578, 3714, 5172, 16373, 41891, 2423, 7649, 2655, 2407, 21292, 4117, 4724, 9640, 1829, 9640, 11622, 34105, 16472, 6055, 9778, 20292, 29739, 4117, 2655, 13546, 25528, 15844, 21136, 9566, 5016, 4032, 7649, 6055, 38251, 5016, 8592, 6055, 3215, 9778, 1211, 32748, 47283, 1211, 5296, 4117, 1829, 6055, 5172, 11242, 1211, 42963, 14851, 2288, 6027, 39896, 4117, 1975, 5016, 8315, 11778, 9778, 1211, 8315, 1975, 2407, 16490, 1211, 9381, 8315, 9673, 5016, 46958, 25720, 18863, 46309, 9957, 4032, 7649, 995, 24525, 10721, 1211, 21984, 8608, 49628, 7649, 3224, 34683, 3615, 6027, 7578], "avg_logprob": -0.33651314911089447, "compression_ratio": 1.8579881656804733, "no_speech_prob": 0.0, "words": [{"start": 1588.19, "end": 1588.59, "word": "يبقى", "probability": 0.79193115234375}, {"start": 1588.59, "end": 1589.23, "word": " مفائدة", "probability": 0.6995849609375}, {"start": 1589.23, "end": 1589.79, "word": " الانتوبيك", "probability": 0.6856689453125}, {"start": 1589.79, "end": 1590.35, "word": " باريارز", "probability": 0.6302490234375}, {"start": 1590.35, "end": 1590.57, "word": " هنا", "probability": 0.89697265625}, {"start": 1590.57, "end": 1591.25, "word": " ان", "probability": 0.7294921875}, {"start": 1591.25, "end": 1591.85, "word": " تخلي", "probability": 0.5552571614583334}, {"start": 1591.85, "end": 1593.31, "word": " البكتيريا", "probability": 0.89814453125}, {"start": 1593.31, "end": 1593.47, "word": " على", "probability": 0.650390625}, {"start": 1593.47, "end": 1593.91, "word": " السطح", "probability": 0.94482421875}, {"start": 1593.91, "end": 1594.53, "word": " وان", "probability": 0.6060791015625}, {"start": 1594.53, "end": 1595.37, "word": " تسمحش", "probability": 0.77056884765625}, {"start": 1595.37, "end": 1595.73, "word": " تدخل", "probability": 0.84954833984375}, {"start": 1595.73, "end": 1596.41, "word": " الداخل", "probability": 0.9435221354166666}, {"start": 1596.41, "end": 1600.33, "word": " لكي", "probability": 0.6048177083333334}, {"start": 1600.33, "end": 1601.15, "word": " تفضل", "probability": 0.70361328125}, {"start": 1601.15, "end": 1602.29, "word": " الاسترال", "probability": 0.6271591186523438}, {"start": 1602.29, "end": 1602.75, "word": " هيك", "probability": 0.4442291259765625}, {"start": 1602.75, "end": 1602.89, "word": " احنا", "probability": 0.83837890625}, {"start": 1602.89, "end": 1603.91, "word": " دخلنا", "probability": 0.860595703125}, {"start": 1603.91, "end": 1604.29, "word": " او", "probability": 0.6993408203125}, {"start": 1604.29, "end": 1605.21, "word": " خلصنا", "probability": 0.9898681640625}, {"start": 1605.21, "end": 1608.37, "word": " المحاضرة", "probability": 0.9776611328125}, {"start": 1608.37, "end": 1608.95, "word": " العشرين", "probability": 0.7742513020833334}, {"start": 1608.95, "end": 1609.73, "word": " وانا", "probability": 0.91064453125}, {"start": 1609.73, "end": 1610.01, "word": " اسأل", "probability": 0.765869140625}, {"start": 1610.01, "end": 1610.19, "word": " الله", "probability": 0.91943359375}, {"start": 1610.19, "end": 1610.43, "word": " سبحانه", "probability": 0.9107666015625}, {"start": 1610.43, "end": 1610.75, "word": " وتعالى", "probability": 0.933837890625}], "temperature": 1.0}, {"id": 67, "seek": 162070, "start": 1611.1, "end": 1620.7, "text": "هذه داخلة في اللي هو آخر الفصل شكرا و السلام عليكم ورحمة الله وبركاته", "tokens": [3224, 24192, 11778, 47283, 37977, 8978, 13672, 1829, 31439, 19753, 34740, 27188, 36520, 13412, 4117, 23557, 4032, 21136, 37440, 25894, 24793, 4032, 2288, 35571, 3660, 21984, 4032, 26890, 4117, 9307, 3224], "avg_logprob": -0.3898925743997097, "compression_ratio": 1.2755102040816326, "no_speech_prob": 2.86102294921875e-06, "words": [{"start": 1611.1, "end": 1612.92, "word": "هذه", "probability": 0.384979248046875}, {"start": 1612.92, "end": 1615.38, "word": " داخلة", "probability": 0.7086588541666666}, {"start": 1615.38, "end": 1616.0, "word": " في", "probability": 0.80517578125}, {"start": 1616.0, "end": 1616.86, "word": " اللي", "probability": 0.5272216796875}, {"start": 1616.86, "end": 1617.18, "word": " هو", "probability": 0.875}, {"start": 1617.18, "end": 1617.88, "word": " آخر", "probability": 0.804931640625}, {"start": 1617.88, "end": 1618.44, "word": " الفصل", "probability": 0.933837890625}, {"start": 1618.44, "end": 1618.8, "word": " شكرا", "probability": 0.7757161458333334}, {"start": 1618.8, "end": 1619.16, "word": " و", "probability": 0.207275390625}, {"start": 1619.16, "end": 1619.54, "word": " السلام", "probability": 0.925537109375}, {"start": 1619.54, "end": 1620.0, "word": " عليكم", "probability": 0.975830078125}, {"start": 1620.0, "end": 1620.56, "word": " ورحمة", "probability": 0.8099365234375}, {"start": 1620.56, "end": 1620.7, "word": " الله", "probability": 0.94482421875}, {"start": 1620.7, "end": 1620.7, "word": " وبركاته", "probability": 0.916015625}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1621.17075, "duration_after_vad": 1577.9287499999973}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/qTsr7hu_iXI_postprocess.srt b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/qTsr7hu_iXI_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..fe17561205fc30a720a6efc00197b4820974cf8a
--- /dev/null
+++ b/PL9fwy3NUQKwY2VeAiCJWVIF9_gd5SI9lJ/qTsr7hu_iXI_postprocess.srt
@@ -0,0 +1,784 @@
+1
+00:00:00,440 --> 00:00:04,200
+أعوذ بالله من الشيطان الرجيم بسم الله الرحمن
+
+2
+00:00:04,200 --> 00:00:08,080
+الرحيم الحمد لله وكفا و أصلي و أسلم على النبي
+
+3
+00:00:08,080 --> 00:00:12,440
+المصطفى نستني في المحاضرات الآن المحاضرة الثانية
+
+4
+00:00:12,440 --> 00:00:16,030
+والعشرينالثانية والعشرون من حيث انتهينا في
+
+5
+00:00:16,030 --> 00:00:21,970
+المحاضرة الحادية والعشرين الآن احنا نتكلم دايما
+
+6
+00:00:21,970 --> 00:00:29,710
+على يعني infection معين في العين فالان احنا لما
+
+7
+00:00:29,710 --> 00:00:36,230
+خدنا في ال atomic في شيء اسمه orbital septum ال
+
+8
+00:00:36,230 --> 00:00:42,110
+orbital septum اللي هي بتفصل مركبات او مكونات ال
+
+9
+00:00:42,110 --> 00:00:47,730
+orbitعن اللي هو الجزء الأمام اذا كان infection
+
+10
+00:00:47,730 --> 00:00:53,690
+قدام ال orbit بيكون preceptal اذا كان infection
+
+11
+00:00:53,690 --> 00:01:01,530
+جوا المحجر ورا ال septum سمى post septal فال
+
+12
+00:01:01,530 --> 00:01:05,230
+preceptal طبعا أهون لأنه في الجزء الأمامي يعني
+
+13
+00:01:05,230 --> 00:01:09,430
+أمام ال orbit و أمام الفياشية هذه اللي هي ال
+
+14
+00:01:09,430 --> 00:01:13,070
+orbital septumهتكلم في الأول على preceptal orbital
+
+15
+00:01:13,070 --> 00:01:18,710
+cellulitis التهاب خلوي التهاب خلوي في ال orbit
+
+16
+00:01:18,710 --> 00:01:25,010
+أمام ال orbital septum المسبببات أيضا هي stuffed
+
+17
+00:01:25,010 --> 00:01:34,830
+coccus aureus وstripped coccusبتعمل الصديق بتيجي
+
+18
+00:01:34,830 --> 00:01:40,810
+لقدام ال septum من skin trauma يعني واحد مثلا ان
+
+19
+00:01:40,810 --> 00:01:51,890
+جرح في جفونه فوق او تحتفتح فتحة سال دم الأطفال
+
+20
+00:01:51,890 --> 00:01:57,750
+اللي ملوث في البكتيريا هذه او الحديدة ملوثة دخلت
+
+21
+00:01:57,750 --> 00:02:06,570
+البكتيريا عن التمزق يعني او في بعض الحشراتيعني
+
+22
+00:02:06,570 --> 00:02:12,850
+بتجرس وفيها بكتيريا بتكون اللي هو الأطراف
+
+23
+00:02:12,850 --> 00:02:17,050
+بتاعتها insect bite يعني معنى الحشرات دي البقوط
+
+24
+00:02:17,050 --> 00:02:27,370
+مثلا اللي هو يعني جزء ثاقب فهذه بتختارق و بتصل
+
+25
+00:02:27,370 --> 00:02:34,860
+لجزء اللي جدام ال orbital septumأو مثلا ممكن انه
+
+26
+00:02:34,860 --> 00:02:39,660
+يكون فيه infection زي heart bulim او Dacrosis
+
+27
+00:02:39,660 --> 00:02:48,720
+تايتس اتهاب اللي هو ال case الدمعأو حتى sinusitis
+
+28
+00:02:48,720 --> 00:02:52,860
+التهاب اللى هو الجيوب الأنفية او kidney arthritis
+
+29
+00:02:52,860 --> 00:02:58,020
+تهاب ال infection في المتحمة او من الدم هي متوجنس
+
+30
+00:02:58,020 --> 00:03:02,680
+يعني من الدم الدم يكون فيه تسمم بكتيري من مناطق
+
+31
+00:03:02,680 --> 00:03:06,920
+بعيدة من الجاذب التنفسى او من ميدلية او من قدر
+
+32
+00:03:06,920 --> 00:03:14,040
+الوسطى يبقى هو ممكن يكون اكتر اشي من برا خاصة skin
+
+33
+00:03:14,040 --> 00:03:20,770
+trauma جريحفي الجلب او from six bites او من حواليه
+
+34
+00:03:20,770 --> 00:03:28,290
+يعني من اللي اللي هو الاتهابات الملتحمة و اللي هو
+
+35
+00:03:28,290 --> 00:03:34,790
+كيس الدم والجوب العنفية او ال middle air بس يعنيها
+
+36
+00:03:34,790 --> 00:03:38,870
+عن طريق الدم من الابر السبب في ال infection من
+
+37
+00:03:38,870 --> 00:03:43,930
+اللي هو الجهاز التنفس العلوي و ال middle air ممكن
+
+38
+00:03:43,930 --> 00:03:53,000
+يجي عن طريق الدمهي مثال كيف الـ preceptal orbital
+
+39
+00:03:53,000 --> 00:03:58,660
+circuit شايفين كيف عينه صعب صعب صعب بيشوف عينه من
+
+40
+00:03:58,660 --> 00:04:02,660
+كتر اللي و أنا فيه
+
+41
+00:04:02,660 --> 00:04:06,480
+power الceptal أخضر لأنه هذه ورا ال orbital system
+
+42
+00:04:06,480 --> 00:04:12,800
+وهذا serious يعني خطير عدو خطير في ال suspicious
+
+43
+00:04:12,800 --> 00:04:13,900
+behind
+
+44
+00:04:17,720 --> 00:04:23,860
+و ممكن تكون life threatening يعني تهدد الحياة تصل
+
+45
+00:04:23,860 --> 00:04:28,480
+للمخ يعني يعني ممكن تصل للمخ و تعمل يعني brain
+
+46
+00:04:28,480 --> 00:04:33,300
+infection أو sight threatening او تعمل العين كلها
+
+47
+00:04:33,300 --> 00:04:37,390
+تبطل تشوففي حالة تكون فيها post septal infection
+
+48
+00:04:37,390 --> 00:04:40,670
+الأطفال
+
+49
+00:04:40,670 --> 00:04:44,170
+المعرضين لها أكتر من الكبار الأطفال المعرضين لها
+
+50
+00:04:44,170 --> 00:04:50,250
+أكتر من الكبار البكتيريات نفس الشيء استربتوا ككة
+
+51
+00:04:50,250 --> 00:04:54,450
+سينيومونيا واستربتوا ككة اوريا واستربتوا ككة
+
+52
+00:04:54,450 --> 00:04:59,790
+بيوجينس وهمفلس انفلونزاطبعا نقول اكترهم اكترهم
+
+53
+00:04:59,790 --> 00:05:04,610
+الاستراب الكوكس اوريس واستراب الكوكس بيو جينز هذه
+
+54
+00:05:04,610 --> 00:05:09,250
+الاكتر اشياء لكن اكترهم تعمل استراب الكوكس
+
+55
+00:05:09,250 --> 00:05:18,510
+النمونيا هذه اكترهم اللي بصيب جهاز تنفسي طيب من
+
+56
+00:05:18,510 --> 00:05:22,490
+وين المصادر المصادر الألجوب الأنفية paranasal
+
+57
+00:05:22,490 --> 00:05:27,280
+sinuses خاصة الاشموتالجيب الأنفي الجيب الأنفي
+
+58
+00:05:27,280 --> 00:05:32,960
+الاسمه SMOD وهذا بيصحى انه يدخل عليهم لانه قريب
+
+59
+00:05:32,960 --> 00:05:39,750
+جدا من ال orbit قريب جدا يعني بيفصلهميعني طبق عضمى
+
+60
+00:05:39,750 --> 00:05:44,670
+لا يقل عن نشور ميلي او يقل حوالى نشور ميلي في
+
+61
+00:05:44,670 --> 00:05:48,970
+السماكه بتاعته فممكن ان يدخل الى ال orbit من
+
+62
+00:05:48,970 --> 00:05:56,750
+ديثمودل برا نزل ساينس طيب بقولي ان ال infection
+
+63
+00:05:56,750 --> 00:06:03,380
+ممكن تيجي برغم ال precept يعني هي صحبريسبتال لكن
+
+64
+00:06:03,380 --> 00:06:06,780
+ممكن تخترق في الفاشية اللى اسمه orbital septum و
+
+65
+00:06:06,780 --> 00:06:11,040
+تخش ممكن تجي من داكسوستاكس اللى هو ال infection
+
+66
+00:06:11,040 --> 00:06:14,960
+بتاعة اللى هو الكيس الدم على نفسه لما يكون فيه
+
+67
+00:06:14,960 --> 00:06:22,380
+صديق اه ممكنdental infection دنتال انفكش يعني
+
+68
+00:06:22,380 --> 00:06:27,220
+الأسنان لما يكون فيه صديق في الأسنان خاصة الأسنان
+
+69
+00:06:27,220 --> 00:06:32,220
+من فوق لما يكون فيها خراج في الأسنان ددر الأسنان
+
+70
+00:06:32,220 --> 00:06:38,800
+أه ممكن تصل أه لفوق وتعمل في ال orbit ممكن من ال
+
+71
+00:06:38,800 --> 00:06:43,260
+facial skin ممكن ال skin اللي بيكون في نص المدينة
+
+72
+00:06:43,260 --> 00:06:49,220
+هنا اللي فوق الأنفأه في المنطقة المستديرة فوق
+
+73
+00:06:49,220 --> 00:06:53,100
+الأنف هذه هذه ممكن لو كان واحد خراج أو حبة و
+
+74
+00:06:53,100 --> 00:06:56,500
+بعصرها و فيها صديد أه ممكن تياجي طريقها إلى ال
+
+75
+00:06:56,500 --> 00:07:00,440
+orbit و تعملوا عشان هيك احنا كنا دايما نقول ان
+
+76
+00:07:00,440 --> 00:07:09,480
+المنطقة هذه المنطقة هذه هيك اللي يعني هي الأنف كنا
+
+77
+00:07:09,480 --> 00:07:18,070
+نقول ان المنطقة هذه هيكاسمها dangerous triangle of
+
+78
+00:07:18,070 --> 00:07:22,730
+the face المنطقة هذه اي قربيشة فيها فوق الأنف
+
+79
+00:07:22,730 --> 00:07:26,050
+خطيرة اللي بين الحجبين تحت
+
+80
+00:07:28,890 --> 00:07:34,470
+بقول ان حتى هذه يعني تيجي من احيانات trauma ضربة
+
+81
+00:07:34,470 --> 00:07:39,870
+يعني يعني حد ادا حد اشهي حد السيارة دخلت بكتيريا
+
+82
+00:07:39,870 --> 00:07:45,830
+او ocular surgery او جراحة داخل العين ممكن جراحة
+
+83
+00:07:45,830 --> 00:07:50,570
+داخل العين ملوثة يعني او blood born او من الدم لو
+
+84
+00:07:50,570 --> 00:07:55,170
+في تسمم اوشي يصل ال organsالمهم البكتيريا هي
+
+85
+00:07:55,170 --> 00:07:59,670
+الأربعة اللي جونا عنهم لو وصلوا إلى المنطقة بتاعة
+
+86
+00:07:59,670 --> 00:08:02,490
+ال orbit ممكن يملوا orbital cirulatus وهذه خطيرة
+
+87
+00:08:02,490 --> 00:08:09,570
+وبتعمل تهديد مش بس للعين اه لأ ممكن تعمل تهديد لل
+
+88
+00:08:09,570 --> 00:08:13,430
+sight لل vision يعني ال vision ممكن يروح او ال
+
+89
+00:08:13,430 --> 00:08:20,950
+life لو وصلت للمخ بعد هيك ممكن الموت طيب
+
+90
+00:08:20,950 --> 00:08:28,820
+دهلأ داكرواديناتس التهاب لغدة الدمع الرئيسة عارفين
+
+91
+00:08:28,820 --> 00:08:32,860
+لغدة الدمع الرئيسة اللي بتكون يعني في المنطقة هذه
+
+92
+00:08:32,860 --> 00:08:39,720
+هنا من جوا هنا هنا شايفين وهي لغدة لما جلب لما جلب
+
+93
+00:08:39,720 --> 00:08:46,720
+الجفن شايفين هذه لغدة الدمع الرئيسة main lacrimal
+
+94
+00:08:46,720 --> 00:08:49,800
+gland اسمها داكرواديناتس التهابها
+
+95
+00:08:52,940 --> 00:08:59,800
+المصادر adiopathic مجهولة والمصدر اللى بنعرفه احنا
+
+96
+00:08:59,800 --> 00:09:05,690
+التانى ال viralاللي هو ممكن مامس مامس انه كاف
+
+97
+00:09:05,690 --> 00:09:13,790
+ابوداج بيعمله مامس اه ابوداج ابستين بار فيروس اسمه
+
+98
+00:09:13,790 --> 00:09:18,030
+ابستين بار أو سايت وميجال وفيروس التالت فيروسات
+
+99
+00:09:18,030 --> 00:09:23,010
+هذه ممكن تعمل اللي هو الذهاب ودة الدمقة الرئيسة
+
+100
+00:09:23,010 --> 00:09:26,510
+rarely بكتيريا يعني البكتيريا أقل اشي يبقى
+
+101
+00:09:26,510 --> 00:09:30,650
+الأغلبية ايديوباكيت مش معروف له سبب والتاني فيرال
+
+102
+00:09:30,650 --> 00:09:32,510
+واقلهم البكتيريا
+
+103
+00:09:34,680 --> 00:09:39,640
+طيب هنتكلم على Stephen Johnson Syndrome Stephen
+
+104
+00:09:39,640 --> 00:09:45,340
+Johnson Syndrome اللي هو في الجفاف هذا هو بيقول
+
+105
+00:09:45,340 --> 00:09:52,440
+انه كتير من اللي هو الأدوية المستعملة أصبحت متهمة
+
+106
+00:09:52,440 --> 00:10:00,180
+بما فيها المضادات الحيوية والصلفات و try me to
+
+107
+00:10:00,180 --> 00:10:04,440
+brim اللي بيحتوي برضه نوع من الصلفةوحتى المساكنات
+
+108
+00:10:04,440 --> 00:10:11,380
+ومنها ال Acamol اللي هو برصيتامول و الأدوية اللي
+
+109
+00:10:11,380 --> 00:10:15,660
+زيه حتى أدوية البرد cold remedies اللي احنا
+
+110
+00:10:15,660 --> 00:10:24,140
+بناخدها للرشح ومضادات التشنج anticonvulsance أصبحت
+
+111
+00:10:24,140 --> 00:10:30,340
+كلها incriminated يعني أصبحت متهمة crime جريمة
+
+112
+00:10:30,340 --> 00:10:35,900
+يعني او مجرمةفي كاسبيل ستيفنز دونسون دونسون دونسون
+
+113
+00:10:35,900 --> 00:10:41,620
+دونسون دونسون دونسون دونسون دونسون دونسون دونسون
+
+114
+00:10:41,620 --> 00:10:42,740
+دونسون دونسون دونسون دونسون دونسون دونسون دونسون
+
+115
+00:10:42,740 --> 00:10:42,860
+دونسون دونسون دونسون دونسون دونسون دونسون دونسون
+
+116
+00:10:42,860 --> 00:10:43,040
+دونسون دونسون دونسون دونسون دونسون دونسون دونسون
+
+117
+00:10:43,040 --> 00:10:48,900
+دونسون دونسون دونسون دونسون دونسون دونسون دونسون
+
+118
+00:10:48,900 --> 00:10:52,980
+دونسون دون
+
+119
+00:10:53,630 --> 00:10:59,370
+منها بكتيريا اسمها Mycoplasma pneumonia وفي فيروس
+
+120
+00:10:59,370 --> 00:11:02,370
+اسمه Herpes Simplex Virus Herpes Simplex Virus
+
+121
+00:11:02,370 --> 00:11:08,650
+اللي بيعمل التقرفة القنانية وبعض أنواع من السرطان
+
+122
+00:11:08,650 --> 00:11:17,430
+تجرم في حدوث الجفاف في العينلأن الأعراض تاخد
+
+123
+00:11:17,430 --> 00:11:25,850
+أسابيع حتى تظهر تتطور و تظهر اه و ممكن تكون many
+
+124
+00:11:25,850 --> 00:11:33,170
+cases of precipitate اي مشتركة ممكن تكون بسبب
+
+125
+00:11:33,170 --> 00:11:39,450
+الفيروس ممكن الأدوية ممكن يعني cancer ممكن يعني
+
+126
+00:11:39,450 --> 00:11:41,050
+عمم الأخرى
+
+127
+00:11:45,360 --> 00:11:50,820
+طيب هنتكلم على ال contact lens wear هل ال contact
+
+128
+00:11:50,820 --> 00:11:54,140
+lens wear اللي هو موضوع عالميا استعمال العجزات
+
+129
+00:11:54,140 --> 00:12:01,200
+اللازقة يعني هذا في يعني ضرب خاصة ال extended use
+
+130
+00:12:01,200 --> 00:12:06,740
+يعني اللي بيستعملها لأسابيع أو لشهور بقول اللي هو
+
+131
+00:12:06,740 --> 00:12:12,280
+risk factor حقيقة كتير على القرنية لأن ال colonial
+
+132
+00:12:12,280 --> 00:12:13,240
+epithelium
+
+133
+00:12:15,330 --> 00:12:19,350
+حساس الهيبوكسيا هيبوكسيا قدرة الأكسجين يبقى
+
+134
+00:12:19,350 --> 00:12:23,450
+القوانين الابيثيرية لأننا نعرف ان النص القرنية
+
+135
+00:12:23,450 --> 00:12:31,310
+الأمامى بتنفس من الهواء الجوي المداب في تير فيلم
+
+136
+00:12:31,310 --> 00:12:36,830
+تري لامينر في الفيلم بس كان حاطينا contact lens
+
+137
+00:12:36,830 --> 00:12:43,000
+لمدة طويلةممكن هذا الاكسجين الجوي يعاق دخوله الى
+
+138
+00:12:43,000 --> 00:12:49,420
+طبقات الابيثينيوم و الانتريار تروما بيقول لإنه
+
+139
+00:12:49,420 --> 00:12:53,260
+جامل hypoxia ال contact lens ممكن تعمل minor
+
+140
+00:12:53,260 --> 00:12:58,360
+trauma أثناء تصليح وتدخيلها تقرحات خفيفة أو جروح
+
+141
+00:12:58,360 --> 00:13:05,290
+خفيفة على سطح القرنيةعشان هيك بقول انه من المهم
+
+142
+00:13:05,290 --> 00:13:13,190
+جدا ان البكتيريا تمنع منها التلتسق بقفة اللي هو
+
+143
+00:13:13,190 --> 00:13:16,960
+العزيزات اللي عصبهاالناس اللي بيلبسوا ال soft
+
+144
+00:13:16,960 --> 00:13:23,220
+contact lens عندهم خطر اكتر او تعرض مخاطرة اكتر
+
+145
+00:13:23,220 --> 00:13:27,680
+انه يصير عندهم امراض في القرانية اكتر من اللي
+
+146
+00:13:27,680 --> 00:13:31,360
+بيلبسوا ال rigid gas permeable contact lens يبقى
+
+147
+00:13:31,360 --> 00:13:35,380
+soft lenses يعني بتلزج على القرانية اكتر بتثنم على
+
+148
+00:13:35,380 --> 00:13:40,220
+القرانية اكتر مجرمة اكتر في حدوث امراض في القرانية
+
+149
+00:13:40,220 --> 00:13:43,180
+من اللي بيستعملوا ال rigid gas permeable contact
+
+150
+00:13:43,180 --> 00:13:52,640
+lensالانفكشن يحدث في القنانية اكتر احتمال
+
+151
+00:13:52,640 --> 00:13:58,660
+حضورها او وجودها انه لما يكون فيه poor lens هيجين
+
+152
+00:13:58,660 --> 00:14:04,060
+يعني الصيانة الصحية ال contact lens تكون ضعيفة و
+
+153
+00:14:04,060 --> 00:14:11,210
+صاحبها جاهل مش فاهم هو يصونا كويسلكن ممكن تصير حتى
+
+154
+00:14:11,210 --> 00:14:15,570
+في اللي وعيين وبيعملوا meticulous lens care ويعني
+
+155
+00:14:15,570 --> 00:14:19,830
+ملتزمين جدا برضه ممكن انه يصير infection في
+
+156
+00:14:19,830 --> 00:14:23,030
+القرنية ويصير فيه keratitis لكن الأكثر لما تكون
+
+157
+00:14:23,030 --> 00:14:27,910
+فيه poor lens هادين ولا شك وحتى ممكن تصير في ال
+
+158
+00:14:27,910 --> 00:14:32,530
+daily disposable lens يعني ليس اللي هو أساس لسخة
+
+159
+00:14:32,530 --> 00:14:36,770
+حقيقة يعني إله ثمن إله ثمن وممكن يصيروا مضاعفات
+
+160
+00:14:42,130 --> 00:14:48,350
+طيب ال fungal keratitis و هذا يعني موضوع تاني اللي
+
+161
+00:14:48,350 --> 00:14:55,250
+هو التهاب القنانية اه بسبب اللي هو الفطريات fungi
+
+162
+00:14:55,250 --> 00:15:01,070
+fungal keratitis بقول دي احنا عندنا نوعين من ال
+
+163
+00:15:01,070 --> 00:15:05,910
+fungi اللي بتعمل keratitis اللي هو الأول yeast فطر
+
+164
+00:15:05,910 --> 00:15:16,170
+خميرةوهذا الجنس بتاعه candida virus fungus هو
+
+165
+00:15:16,170 --> 00:15:26,930
+بيضاوي واحد الخلية اه وينمو بالتبرعم اه ومسئول عن
+
+166
+00:15:26,930 --> 00:15:33,210
+كتير من ال fungal keratitis اه في الأجواء اللى هو
+
+167
+00:15:33,210 --> 00:15:39,750
+الدافعةالثاني فلمانتس فنجاي الفطريات الخيطية
+
+168
+00:15:39,750 --> 00:15:43,870
+الفيزاريام
+
+169
+00:15:43,870 --> 00:15:50,230
+والاسبرجيلاس اسبرجيلاس هذا مش واحد الخلايا هذا
+
+170
+00:15:50,230 --> 00:15:55,570
+متعدد الخلايا multi cellular organisms that
+
+171
+00:15:55,570 --> 00:16:00,770
+produce tubular projections يعني هذا بيعمل نمو
+
+172
+00:16:00,770 --> 00:16:08,810
+خيطياسمه hyphy النمو الخيطي بتاعه هيك خلايا ا
+
+173
+00:16:08,810 --> 00:16:13,970
+خلايا واربعة والخلايا هذه في الآخر اسمها hypha
+
+174
+00:16:13,970 --> 00:16:19,530
+والمجموع بتاعة hypha هي hyphaيبقى بنوع ما الهايفي
+
+175
+00:16:19,530 --> 00:16:27,030
+هي الأكثر انتشارا في الأجواء الدافعة أه الساكنة
+
+176
+00:16:27,030 --> 00:16:32,630
+يعني أكتر من بلدنا لكن قليل ما كانوا في الأجواء
+
+177
+00:16:32,630 --> 00:16:40,470
+الباردة ال keratitis aggressive of course يعني انا
+
+178
+00:16:40,470 --> 00:16:46,080
+عارف ال bacterial ولا ال fungalالبكتيريا الأسهل
+
+179
+00:16:46,080 --> 00:16:49,340
+لإنه Antibacterial drugs بتجيب نتيجة لكن ال
+
+180
+00:16:49,340 --> 00:16:52,680
+antifungal صعبة aggressive course يعني هي بتبقى
+
+181
+00:16:52,680 --> 00:16:57,180
+شديدة وممكن تعمل عمى على المعينة وهي الصور بتاعة
+
+182
+00:16:57,180 --> 00:17:02,440
+ال fungal keratitis اللي بتتفرجوا عليهاعامل تلايف
+
+183
+00:17:02,440 --> 00:17:07,920
+في القرانية الفانجاس هنا هي filamentous keratitis
+
+184
+00:17:07,920 --> 00:17:14,080
+number B وهي number B هنا وهي candida albicans هنا
+
+185
+00:17:14,080 --> 00:17:22,320
+في أوله وبعدين تشوف there is large exterior
+
+186
+00:17:22,320 --> 00:17:29,780
+defectsA في الـ B و FALSE تابع اسم اسم ال brain و
+
+187
+00:17:29,780 --> 00:17:35,540
+بعدين Satellite legions هنا في ال D يعني نجمي
+
+188
+00:17:35,540 --> 00:17:42,080
+ستيلايت زي النجمة كيف عملت خربت القرنيةhigh fungal
+
+189
+00:17:42,080 --> 00:17:46,180
+keratitis في الآخر شايفين كيف عملت تليف ring
+
+190
+00:17:46,180 --> 00:17:51,180
+infiltrate with satellite regions and hypopion
+
+191
+00:17:51,180 --> 00:17:57,020
+hypopion يعني صديد داخل الحجرة الأمامية للعين انا
+
+192
+00:17:57,020 --> 00:17:58,280
+مابدش أطول عليكم
+
+193
+00:18:03,260 --> 00:18:08,700
+هتوقف انا يعني عند الحد هذا اكلتي موبة للمرة
+
+194
+00:18:08,700 --> 00:18:12,280
+الجاية اكلتي موبة ان شاء الله على ان ان شاء الله
+
+195
+00:18:12,280 --> 00:18:17,540
+نستهنف بعد ذلك انا اشكركم والسلام عليكم ورحمة الله
+
+196
+00:18:17,540 --> 00:18:19,340
+وبركاته
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/-1r5WwuGBZ4.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/-1r5WwuGBZ4.srt
new file mode 100644
index 0000000000000000000000000000000000000000..d0a8266f572b69d9e3d0bd11f1c43322d15bec72
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/-1r5WwuGBZ4.srt
@@ -0,0 +1,1895 @@
+1
+00:00:01,600 --> 00:00:05,160
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:05,160 --> 00:00:10,440
+المرسلين سيدنا محمد الصادق الأمين  أما بعد استكمال
+
+3
+00:00:10,440 --> 00:00:13,260
+اللي ما بدأنا فيه في المحاضرة السابقة حول
+
+4
+00:00:13,260 --> 00:00:17,580
+الـSpermatogenesis والـOogenesis تحدثنا أن كلا
+
+5
+00:00:17,580 --> 00:00:22,580
+العمليتين تتشابه في نقطة وتختلف في ثلاث نقط تتشابه
+
+6
+00:00:22,580 --> 00:00:26,890
+في الـPrimordial أو الـEmbryonic Germ Cell وتختلف
+
+7
+00:00:26,890 --> 00:00:31,210
+في انقسام الميتوزي وانقسام الميوزي و الـfunctional
+
+8
+00:00:31,210 --> 00:00:36,170
+and structural maturation of oocyte and sperm ثم
+
+9
+00:00:36,170 --> 00:00:41,030
+تطرقنا إلى الـoocyte بشكلها الكامل وتحدثنا أن الـ
+
+10
+00:00:41,030 --> 00:00:48,230
+oocyte تبقى في مرحلة مبكرة جدا تحت مسمى oogonium
+
+11
+00:00:50,720 --> 00:00:55,820
+ثم تدخل في انقسام الميتوزي بشكل كامل لمرات متعددة
+
+12
+00:00:55,820 --> 00:01:00,580
+وتنهي الانقسام الميتوزي على شكل الـprimary oocyte
+
+13
+00:01:00,580 --> 00:01:04,480
+الـprimary oocyte تدخل في انقسام الميوزي الأول
+
+14
+00:01:04,480 --> 00:01:11,220
+وتستقر في stage بنسميه Diploten stage تبقى في هذا
+
+15
+00:01:11,220 --> 00:01:17,820
+الـphase حتى سن البلوغ بمجرد حدوث ووصول الـfemale
+
+16
+00:01:17,820 --> 00:01:25,000
+إلى سن البلوغ يبدأ الـovary كل شهر في انضاج 10 إلى
+
+17
+00:01:25,000 --> 00:01:30,460
+30 primary oocyte تستكمل انقسام الميوز الأول وتدخل
+
+18
+00:01:30,460 --> 00:01:34,320
+في انقسام الميوز الثاني وتستقر وتدخل في انقسام
+
+19
+00:01:34,320 --> 00:01:39,180
+الميوز الثاني تدخل في انقسام الميوز الثاني على شكل
+
+20
+00:01:39,180 --> 00:01:43,440
+أيضًا زي ما شفنا في الصورة السابقة من المحاضرة
+
+21
+00:01:43,440 --> 00:01:49,990
+السابقة دخلت الـprimary oocyte تملتالانقسام الميوزي 
+
+22
+00:01:49,990 --> 00:01:53,470
+الأول اللي كان واقف في مرحلة الـdiplotent stage
+
+23
+00:01:53,470 --> 00:01:57,890
+كملت انقسام الميوزي الأول بشكله الكامل أعطتلي
+
+24
+00:01:57,890 --> 00:02:02,490
+secondary oocyte زائد first polar body الـ
+
+25
+00:02:02,490 --> 00:02:07,350
+secondary oocyte تستمر في الانقسام الميوزي الثاني
+
+26
+00:02:07,350 --> 00:02:14,010
+حتى لحظة الـovulation ولكن قبل الـovulation بتكون
+
+27
+00:02:14,010 --> 00:02:18,070
+واكفة هذه البويضة اللي اسمها secondary oocyte في
+
+28
+00:02:18,070 --> 00:02:23,470
+مرحلة الـMetaphase 2 طبعا هذه العملية الـ20 أو
+
+29
+00:02:23,470 --> 00:02:27,530
+30 خلية اللي كانت على شكل الـprimary oocyte ووصلت
+
+30
+00:02:27,530 --> 00:02:31,630
+على شكل الـ30 مشكلهم بيخضعوا لعملية الـovulation
+
+31
+00:02:31,630 --> 00:02:35,970
+الطويلة الطويلة تنتين، واحد، اتنين، تلاتة، وايضا
+
+32
+00:02:35,970 --> 00:02:39,810
+على الأكثر والباقي بيروح لمرحلة الاتريجيا أو
+
+33
+00:02:39,810 --> 00:02:43,570
+الأتريجيا بشكل كامل وهي عبارة عن الـdegeneration
+
+34
+00:02:43,570 --> 00:02:48,240
+of oocyte هذه العملية تستمر بهذا الشكل كل شهر لمدة
+
+35
+00:02:48,240 --> 00:02:55,400
+45 أو 50 سنة الـsecondary oocyte تبدأ في الانقسام
+
+36
+00:02:55,400 --> 00:03:01,300
+الميوزي لكن هذه السلسلة ستكون مقفلة في مرحلة
+
+37
+00:03:01,300 --> 00:03:05,820
+محددة تسمى Metaphase II وهو الانقسام الميوزي
+
+38
+00:03:05,820 --> 00:03:10,620
+الثاني في مرحلة الـMetaphase وهي مرحلة استعداد
+
+39
+00:03:10,620 --> 00:03:16,540
+الكروموزومات في منتصف الخلية عبارة عن 2n-chromosome أو
+
+40
+00:03:16,540 --> 00:03:22,220
+2n استعدادا للـfertilization ماهي اللي بيخليها تستكمل
+
+41
+00:03:22,220 --> 00:03:25,040
+اقسام الميوزي الثاني هي عبارة عن عملية الـ
+
+42
+00:03:25,040 --> 00:03:27,960
+fertilization the stimulation for the releasing
+
+43
+00:03:27,960 --> 00:03:31,380
+from this meiotic block is fertilization by
+
+44
+00:03:31,380 --> 00:03:34,760
+spermatozoon يعني بمجرد البويضة اللي واقفة في
+
+45
+00:03:34,760 --> 00:03:38,890
+الـmetaphase 2 والتي تحتوي على 2n-chromosome ومجرد
+
+46
+00:03:38,890 --> 00:03:42,470
+حدوث عملية تلقيح لها بيبدأ تشغيل على هذا البويضة ده
+
+47
+00:03:42,470 --> 00:03:46,630
+عشان تستكمل تسعى الميوزي الثاني الـUnfertilized
+
+48
+00:03:46,630 --> 00:03:51,290
+secondary oocyte will be degenerated or will be failure
+
+49
+00:03:51,290 --> 00:03:55,630
+to complete the secondary meiotic division الـ
+
+50
+00:03:55,630 --> 00:03:58,670
+secondary meiotic division مش هتقدر تكمله فبالتالي
+
+51
+00:03:58,670 --> 00:04:04,860
+هتدخل في مرحلة الاتريجيا أو تنزل مع الـbleeding أو
+
+52
+00:04:04,860 --> 00:04:09,220
+مع الـmenstrual cycle على هيئة secondary oocyte
+
+53
+00:04:09,220 --> 00:04:12,200
+the first polar body may be divided during the
+
+54
+00:04:12,200 --> 00:04:16,540
+secondary mitotic division as we see in the last
+
+55
+00:04:16,540 --> 00:04:22,340
+video خلينا نشوف هذا الفيديو اللي بيتكلم أيضا عن
+
+56
+00:04:22,340 --> 00:04:27,880
+عملية الـoogenesis وكيف تتم ولكن هذا بيتحدث عن الـ
+
+57
+00:04:27,880 --> 00:04:32,010
+polar body بشكل عام هي في عندي primary oocyte فيها
+
+58
+00:04:32,010 --> 00:04:35,930
+أحد اثنين تلاتة اربعة four كروموزوم فكده بنسميها في
+
+59
+00:04:35,930 --> 00:04:39,590
+الأصل لازم تكون اثنين فكده سميناها diploid 2n
+
+60
+00:04:39,590 --> 00:04:45,930
+هتدخل انقسام الميوزي الأول قسمت انقسام الميوزي
+
+61
+00:04:45,930 --> 00:04:50,330
+الأول خلصت من نصف عدد الكروموزومات أعطتني خلية
+
+62
+00:04:50,330 --> 00:04:53,570
+تحتوي على two كروموزوم وخلية تحتوي على two كروموزوم
+
+63
+00:04:53,570 --> 00:04:55,830
+هذه خلية تحتوي على كمية كافية من الـcytoplasm
+
+64
+00:04:55,830 --> 00:05:00,910
+فسماها primary or secondary oocyte و هذه خلية تحتوي
+
+65
+00:05:00,910 --> 00:05:05,770
+على عدد قليل جدا من العضيات وكمية صغيرة جدا من
+
+66
+00:05:05,770 --> 00:05:09,190
+الـcytoplasm اللي هي تكفي للاستمرار فبسميها polar
+
+67
+00:05:09,190 --> 00:05:13,750
+body طبعا
+
+68
+00:05:13,750 --> 00:05:17,650
+هذه الـfirst polar body تدخل انقسام الميوزي الثاني
+
+69
+00:05:17,650 --> 00:05:20,890
+عشان توصل لـmetaphase بمجرد حدوث الـ
+
+70
+00:05:20,890 --> 00:05:25,970
+fertilization تبدأ بتتخلص من نصف عدد الكروموزومات
+
+71
+00:05:25,970 --> 00:05:30,890
+وتحصل على كروموزوم من الأب وكروموزوم من الأم وحصلت على
+
+72
+00:05:30,890 --> 00:05:34,310
+two polar bodies وخليكم فاكرين المعلومة هذه إن
+
+73
+00:05:34,310 --> 00:05:39,890
+الخلية إذا كانت mature بتكون خلية تحتوي على two
+
+74
+00:05:39,890 --> 00:05:42,890
+chromosomes for example إذا كنا بنحكي إنه عدد
+
+75
+00:05:42,890 --> 00:05:46,190
+الكروموزومات الأصلية اثنين ولكن تحتوي بجوارها على
+
+76
+00:05:46,190 --> 00:05:49,690
+first polar body بعد الـfertilization ما بتصير
+
+77
+00:05:49,690 --> 00:05:54,710
+first polar body في عند الـsecond polar body تبعد
+
+78
+00:05:54,710 --> 00:05:58,090
+الكروموزومات في الخلية قبل عملية الـfertilization
+
+79
+00:05:58,090 --> 00:06:04,490
+لازم تكون employed لازم تكون employed لمجرد حدوث
+
+80
+00:06:04,490 --> 00:06:10,270
+الـfertilization علشان تستكمل عملية التطوير هذا
+
+81
+00:06:10,270 --> 00:06:15,290
+بالنسبة إلى الـfemale خلينا نشوف استكمال هذه
+
+82
+00:06:15,290 --> 00:06:20,210
+العملية، ماذا سيحدث فيما بعد قلنا من الـFemale
+
+83
+00:06:20,210 --> 00:06:23,550
+وماذا سيحدث مع الـFemale خلال عملية الـOogenesis
+
+84
+00:06:23,550 --> 00:06:27,210
+وكيف تتطور البويضات وفي أي مرحلة تجهز وفي أي stage
+
+85
+00:06:27,210 --> 00:06:32,250
+وكيف تتصير من 2c إلى 1c يعني من 2 كروموزوم إلى 1
+
+86
+00:06:32,250 --> 00:06:36,950
+كروموزوم نجي للميل، وهو القسم الميوزي للـFemale
+
+87
+00:06:36,950 --> 00:06:43,090
+القسم الميوزي للـFemale in the male does not
+
+88
+00:06:43,090 --> 00:06:47,850
+begin until after puberty يعني ما بيصير انقسام
+
+89
+00:06:47,850 --> 00:06:54,350
+ميوزي عند الذكور إلا بعد عملية البلوغ وهذا بخلاف
+
+90
+00:06:54,350 --> 00:06:58,210
+اللي بيحدث عند الـfemale بخلاف ما يحدث عند الـ
+
+91
+00:06:58,210 --> 00:07:03,010
+female الشغل الثاني الخلاف الثاني انه مش كل الـ
+
+92
+00:07:03,010 --> 00:07:06,990
+spermatogonium تخضع لانقسام الميوزي وإلا ما بيصير
+
+93
+00:07:06,990 --> 00:07:10,530
+في عند استمرارية في إنتاج الـsperm وإلا كلهم خضعوا
+
+94
+00:07:10,530 --> 00:07:13,510
+لانقسام الميوزي كلهم بقى فترة زمنية بيصيرها
+
+95
+00:07:13,510 --> 00:07:17,610
+degeneration فما بيصير عندي spermato site موجودة
+
+96
+00:07:17,610 --> 00:07:20,770
+ما بيصير عندي spermato zoo موجودة فبيصير عند الـ
+
+97
+00:07:20,770 --> 00:07:24,970
+fertility إذا النقطتين أساسيتين النقطة الأولى إن
+
+98
+00:07:24,970 --> 00:07:29,830
+انقسام الميوزي عند الذكور ما بيبدأ إلا بعد سن
+
+99
+00:07:29,830 --> 00:07:35,230
+البلوغ انقسام الميوزي للـspermatogonia عند الذكور
+
+100
+00:07:35,230 --> 00:07:40,010
+ما بيبدأ كله مع بعض في نفس اللحظة بيبدأ على فترات A
+
+101
+00:07:40,010 --> 00:07:43,890
+large number of spermatogonia spermatogonia remain
+
+102
+00:07:43,890 --> 00:07:48,290
+in meiotic cycle throughout much of the
+
+103
+00:07:48,290 --> 00:07:52,870
+reproductive lifetime of male يعني كله بيصير ويبقى
+
+104
+00:07:52,870 --> 00:07:55,590
+في انقسام الميتوزي ويستمر في انقسام الميتوزي
+
+105
+00:07:55,590 --> 00:07:59,890
+بشكل مستمر وإلا كيف بيحصل على 200 مليون و150 مليون
+
+106
+00:07:59,890 --> 00:08:03,330
+و20 مليون بيحصل على هذا الكم من عدد الحيوانات
+
+107
+00:08:03,330 --> 00:08:08,630
+المنوية من خلال استمرارية انقسام الخلوي تحت مسمى
+
+108
+00:08:08,630 --> 00:08:13,460
+الـmeiotic division طيب الـspermatogonium تدخل في
+
+109
+00:08:13,460 --> 00:08:17,420
+مرحلة انقسام الميوزي الأول على شكل primary
+
+110
+00:08:17,420 --> 00:08:24,060
+spermatocyte they spent several weeks
+
+111
+00:08:24,060 --> 00:08:29,160
+passing through the first meiotic division يعني في
+
+112
+00:08:29,160 --> 00:08:34,060
+عندي spermatogonium خضعت لانقسام الميتوزي بشكل
+
+113
+00:08:34,060 --> 00:08:38,500
+كبير جدا هتدخل الـspermatogonium على شكل
+
+114
+00:08:38,500 --> 00:08:42,560
+spermatocyte primary spermatocyte انقسام الميوزي
+
+115
+00:08:42,560 --> 00:08:47,880
+الميوزي الأول وتبقى تستهلك وقت كبير جدا في انقسام
+
+116
+00:08:47,880 --> 00:08:52,320
+الميوزي الأول الميوزي الأول قد يصل إلى عدة أسابيع
+
+117
+00:08:52,320 --> 00:08:58,000
+عملية تخليق الـspermatocyte من بدايتها من منطقة الـ
+
+118
+00:08:58,000 --> 00:09:03,020
+spermatogonium حتى منطقة الـmature sperm تأخذ 74
+
+119
+00:09:03,020 --> 00:09:08,990
+يوم plus minus 74 يوم مش fixed ولكن بقول plus
+
+120
+00:09:08,990 --> 00:09:14,050
+minus هذه الـbackground بيبين ليه مراحل تطور الـ
+
+121
+00:09:14,050 --> 00:09:17,250
+spermatogonium في عند البداية spermatogonium
+
+122
+00:09:17,250 --> 00:09:23,030
+primary spermatocyte secondary spermatocyte
+
+123
+00:09:23,030 --> 00:09:28,190
+spermatid 4 spermatozoon إذا الأولى spermatogonium
+
+124
+00:09:28,190 --> 00:09:32,900
+و هي الخلية الأم خلينا نسميها الـspermatozoa أو
+
+125
+00:09:32,900 --> 00:09:38,520
+الـsperm هي عبارة عن الـmature sperm في مرحلة
+
+126
+00:09:38,520 --> 00:09:41,740
+بيسميها spermatogenesis و هي عبارة عن عملية
+
+127
+00:09:41,740 --> 00:09:46,500
+التخليق بشكل كامل ماذا يحصل؟ في الـspermatogonium
+
+128
+00:09:46,500 --> 00:09:51,380
+يتضاعف المادة الوراثية تتصير 4n يعني أربعة
+
+129
+00:09:51,380 --> 00:09:55,960
+كروموزوم تدخل الأقسام الميوزي الأول على شكل الـ
+
+130
+00:09:55,960 --> 00:10:00,550
+primary spermatocyte فيها أربعة كروموزومات للتقريب
+
+131
+00:10:00,550 --> 00:10:04,890
+للتقريب عدد الكروموزومات بيكتمل القسم الميوزي
+
+132
+00:10:04,890 --> 00:10:10,550
+الأول فكل sperm فكل primary spermatocyte تعطيني
+
+133
+00:10:10,550 --> 00:10:14,790
+خليتين كل خلية فيها نصف عدد الكروموزومات فالأصل كان
+
+134
+00:10:14,790 --> 00:10:18,990
+في عندي أربعة كروموزومات هينقسموا الاثنين هتعطيني
+
+135
+00:10:18,990 --> 00:10:23,090
+خليتين كل خلية فيها اثنين كروموزوم عشان كده سماها
+
+136
+00:10:23,090 --> 00:10:27,630
+secondary spermatocyte من حيث الاسم ولكن من حيث
+
+137
+00:10:27,630 --> 00:10:32,170
+شكل الـtwo two secondary spermatocyte إذاً خليتين
+
+138
+00:10:32,170 --> 00:10:36,530
+اثنين في اثنين كروموزوم أربعة كروموزومات بعد كده
+
+139
+00:10:36,530 --> 00:10:41,050
+بيستمر الانقسام الميوزي الثاني فكل خلية بتعطيني
+
+140
+00:10:41,050 --> 00:10:46,690
+خليتين فتوصف الـsecondary spermatocyte بتعطيني four
+
+
+141
+00:10:46,690 --> 00:10:52,710
+spermatin كل خلية فيها نصف عدد كروموسومات secondary
+
+142
+00:10:52,710 --> 00:10:56,350
+spermatin أو أفر secondary spermatocyte اللي هي 
+
+143
+00:10:56,350 --> 00:11:00,230
+عبارة عن اتنين كروموسوم يعني فيها one كروموسوم بعدين
+
+144
+00:11:00,230 --> 00:11:05,830
+تبدأ عملية الـ maturation عشان نحصل على Spermatozoa
+
+145
+00:11:05,830 --> 00:11:09,150
+عملية الـ maturation بتاخد لها من أسبوعين لثلاث 
+
+146
+00:11:09,150 --> 00:11:12,990
+أسابيع إذا ال spermatogonium عشان يصير DNA
+
+147
+00:11:12,990 --> 00:11:17,810
+replication بتاخد لها 16 يوم كـ duration الـ primary
+
+148
+00:11:17,810 --> 00:11:21,630
+spermatocyte عشان تخلص انقسام الميوزي الأول بتاخد
+
+149
+00:11:21,630 --> 00:11:26,850
+لها 24 يوم maximum 30 secondary spermatocyte عشان
+
+150
+00:11:26,850 --> 00:11:32,180
+تخلص انقسام الميوزي الثاني بتاخد لها يوم كامل الـ
+
+151
+00:11:32,180 --> 00:11:35,720
+spermatease عشان تتطور و تعطيني immature haploid
+
+152
+00:11:35,720 --> 00:11:41,380
+جُميّد تعطيني تقريبا أربعة و سبعة و عشرين يوم سبعة و
+
+153
+00:11:41,380 --> 00:11:45,480
+عشرين يوم و يوم ثمانية و عشرين ثمانية و عشرين و
+
+154
+00:11:45,480 --> 00:11:51,660
+أربعة و عشرين جول تلاتين تلاتين اثنين و خمسين و
+
+155
+00:11:51,660 --> 00:11:57,670
+ستة ثمانية و خمسين عشرة ثمانية و سبعين ثمانية و
+
+156
+00:11:57,670 --> 00:12:02,470
+سبعين plus minus لو زودت للتلاتين أو للتمنبعش
+
+157
+00:12:02,470 --> 00:12:08,190
+هتلاقي أربعة و سبعين يوم زاد minus زاد ناقص أكثر
+
+158
+00:12:08,190 --> 00:12:12,670
+من يوم عملية الـ maturation للـ spermatin وتحويلها
+
+159
+00:12:12,670 --> 00:12:16,650
+إلى الـ spermatozoa أو الـ sperm تاخدلها أسبوعين
+
+160
+00:12:16,650 --> 00:12:20,870
+تاخدلها أسبوعين تاخدلها two week
+
+161
+00:12:22,890 --> 00:12:27,370
+طبعا هذه شكل الـ Testis الخاص بالميل في منطقة
+
+162
+00:12:27,370 --> 00:12:30,450
+بنتسميها الـ Epididymis أو البربخ وهي المنطقة اللي
+
+163
+00:12:30,450 --> 00:12:33,870
+تخزن فيها الـ Sperm الـ Vas Deferens اللي هو
+
+164
+00:12:33,870 --> 00:12:37,670
+العقل الناقل و الـ Testis اللي فيها الـ seminiferous
+
+165
+00:12:37,670 --> 00:12:43,370
+تيوبول المصنع اللي بتنفيه الرصنية الـ sperm لو أخدت
+
+166
+00:12:43,370 --> 00:12:46,190
+مقفلة من الـ seminiferous هلاجي في عندي خلية
+
+167
+00:12:46,190 --> 00:12:49,710
+بتسميها الـ Sertoli cell هعرف الـ function الخاصة
+
+168
+00:12:49,710 --> 00:12:53,490
+بالـ Sertoli cell بشكل كامل في المحاضرات القادمة
+
+169
+00:12:53,490 --> 00:12:58,350
+سيرتوليسيل تبدأ حواليها spermatogonia أو 
+
+170
+00:12:58,350 --> 00:13:02,650
+spermatogonia تنقسم انقسام ميوزي للوصول لـ 
+
+171
+00:13:02,650 --> 00:13:07,330
+spermatocyte spermatocyte بتخلص انقسام الميوزي
+
+172
+00:13:07,330 --> 00:13:11,830
+الأول عشان تعطيني secondary spermatocyte عدد اثنين
+
+173
+00:13:11,830 --> 00:13:15,250
+secondary spermatocyte عدد اثنين هتدخل في انقسام
+
+174
+00:13:15,250 --> 00:13:18,650
+الميوزي الثاني هتعطيني أربع خلايا بتسميها
+
+175
+00:13:18,650 --> 00:13:22,020
+spermatids الأربع خلايا الـ spermatid هيصلها
+
+176
+00:13:22,020 --> 00:13:26,740
+maturation وطياطيني لـ sperm أو لـ spermatozoa
+
+177
+00:13:26,740 --> 00:13:30,100
+يعني في المقالات العلمية بيسموها sperm أو بيسموها 
+
+178
+00:13:30,100 --> 00:13:34,100
+mature sperm أو بيسموها spermatozoa لو أخدت الـ one
+
+179
+00:13:34,100 --> 00:13:39,940
+sperm هلاجي فيه تركيبة الـ head الـ mid piece و الـ
+
+180
+00:13:39,940 --> 00:13:43,180
+tail الـ tail مهم جدا للحركة الـ mid piece فيها
+
+181
+00:13:43,180 --> 00:13:47,320
+ميتوكوندريا لإنتاج الطاقة والـ Head فيه الـ Acrosome
+
+182
+00:13:47,320 --> 00:13:50,160
+الخاص بالـ Fertilization لأنه فيه إنزيمات تساعد
+
+183
+00:13:50,160 --> 00:13:53,460
+على اختراق البويضة سنعرف ما هو الـ Acrosome وكيف
+
+184
+00:13:53,460 --> 00:13:56,380
+تصبح الـ Lysis وماذا عن إنزيمات اللي فيه وفيه أند
+
+185
+00:13:56,380 --> 00:14:01,420
+النواة وهي المادة الوراثية الخاصة بالأب هل الـ
+
+186
+00:14:01,420 --> 00:14:06,280
+sperm يحتوي على Single Mitochondria لأ الـ sperm
+
+187
+00:14:06,280 --> 00:14:11,410
+يحتوي على أكثر من من خمسين لسبعين ميتوكوندريا إذا
+
+188
+00:14:11,410 --> 00:14:15,770
+مافي عندي خلية فيها single ميتوكوندريا زي الـ sperm
+
+189
+00:14:15,770 --> 00:14:19,210
+لأ في من خمسين لسبعين وفي بعض الدراسات بتقول 100
+
+190
+00:14:19,210 --> 00:14:24,470
+ميتوكوندريا موجودة بالـ sperm صورة بتوضح الفرق ما بين
+
+191
+00:14:24,470 --> 00:14:29,610
+الـ oogenesis على اليمين مقارنة بالـ spermatogenesis
+
+192
+00:14:29,610 --> 00:14:34,640
+هنبدأ بالـ oogenesis هتبدأ بالـ Oogonium هأمر بعد
+
+193
+00:14:34,640 --> 00:14:38,720
+انقسام الميتوزي primary oocyte هتدخل انقسام
+
+194
+00:14:38,720 --> 00:14:42,440
+الميوزي الأول secondary oocyte زائد first polar body
+
+195
+00:14:42,440 --> 00:14:47,240
+انقسام الميوزي الثاني هتعطيني oocyte زائد second
+
+196
+00:14:47,240 --> 00:14:51,120
+polar body بعد الـ fertilization فأخدوا فالك بعد الـ
+
+197
+00:14:51,120 --> 00:14:53,720
+fertilization لازم يطلع الـ secondary polar body
+
+198
+00:14:53,720 --> 00:14:58,680
+اسم الـ oogonium هتدخل عملية التطوير للمادة
+
+199
+00:14:58,680 --> 00:15:02,360
+الوراثية وتضاعفها تديني primary من خلال انقسام
+
+200
+00:15:02,360 --> 00:15:05,740
+الميتوزي تعطي primary spermatocyte عشان كده بما
+
+201
+00:15:05,740 --> 00:15:10,000
+يقول growth و maturation معناه انقسام ميتوزي الـ
+
+202
+00:15:10,000 --> 00:15:13,340
+primary و الـ oocyte هتدخل انقسام ميوزي أول هتعطيني
+
+203
+00:15:13,340 --> 00:15:18,120
+secondary و secondary هتعطيني two secondary 
+
+204
+00:15:18,120 --> 00:15:21,360
+spermatocyte كل واحدة منهم هتدخل انقسام ميوزي ثاني
+
+205
+00:15:21,360 --> 00:15:24,080
+هتعطيني spermatide الـ spermatide بسبب الـ
+
+206
+00:15:24,080 --> 00:15:25,680
+maturation و الـ differentiation هتعطيني 
+
+207
+00:15:25,680 --> 00:15:30,540
+spermatozoa نيجي لأخر stage من مراحل الـ
+
+208
+00:15:30,540 --> 00:15:33,880
+spermatogenesis و الـ oogenesis وهو عبارة عن الـ
+
+209
+00:15:33,880 --> 00:15:36,740
+Final Structure and Functional Maturation of 
+
+210
+00:15:36,740 --> 00:15:41,740
+Oocyte and Sperm ناخدها واحدة واحدة الـ Oogenesis
+
+211
+00:15:41,740 --> 00:15:46,940
+وهي عبارة عن عملية تخليق البويضة حوالي عدد
+
+212
+00:15:46,940 --> 00:15:52,040
+البويضات الموجودة في الـ Ovary في مرحلة جنينية
+
+213
+00:15:52,040 --> 00:15:57,620
+تقدر بـ 7 مليون بويضة ولكن اللي بصل لمرحلة الـ
+
+214
+00:15:57,620 --> 00:16:02,060
+primary oocyte فقط 2 مليون بويضة يعني عندك حوالي
+
+215
+00:16:02,060 --> 00:16:07,960
+5 مليون بويضة دخلت مرحلة الـ atresia طيب لما تصير
+
+216
+00:16:07,960 --> 00:16:14,680
+ميلاد ونحصل على طفل جنسه أنثى المبيض في هذا الوقت
+
+217
+00:16:14,680 --> 00:16:22,560
+only about 600000 of oocyte هتكون arrested في
+
+218
+00:16:22,560 --> 00:16:27,740
+مرحلة الضيب latent stage من أصل اثنين مليون يعني
+
+219
+00:16:27,740 --> 00:16:34,100
+الباقي صار له اتراجع of the first mitotic division
+
+220
+00:16:34,100 --> 00:16:38,860
+survival until puberty يعني السبعة مليون اللي
+
+221
+00:16:38,860 --> 00:16:44,440
+كانوا في المبيعات بمجرد.. بمجرد الميلاد بيصيروا
+
+222
+00:16:44,440 --> 00:16:50,520
+اثنين مليون الاثنين مليون بمجرد وصول إلى سن البلوغ
+
+223
+00:16:50,520 --> 00:16:54,400
+بيصيروا ستمائة ألف بويضة من سبعة مليون صاروا اثنين
+
+224
+00:16:54,400 --> 00:17:00,680
+مليون بعدين ستمائة.. ستمائة ألف بويضة بعد الـ
+
+225
+00:17:00,680 --> 00:17:05,240
+puberty وبمجرد ما تبدأ الـ menstrual cycle السيدة
+
+226
+00:17:05,240 --> 00:17:09,460
+بتفقد تقريبا.. تقريبا مائة بويضة طبعا مش مائة 
+
+227
+00:17:09,460 --> 00:17:13,080
+بويضة يروحوا مع الـ bleeding لأ مائة بويضة في كل
+
+228
+00:17:13,080 --> 00:17:18,700
+دورة تترجى immature egg every month only a single
+
+229
+00:17:18,700 --> 00:17:24,960
+egg should be At least there are exceptions which
+
+230
+00:17:24,960 --> 00:17:30,680
+in some cases lead to twins عشان هنا كده بقولك أن
+
+231
+00:17:30,680 --> 00:17:35,900
+الأنثى لما تصل لسن البلوغ هيكون فيها عندها 600 ألف
+
+232
+00:17:35,900 --> 00:17:41,900
+بويضة مستقرة في الـ diploid rotten stage ومستعدة تدخل
+
+233
+00:17:41,900 --> 00:17:48,340
+متسامل الميوزي الثاني كل شهر من بعد البلوغ السيدة 
+
+234
+00:17:48,340 --> 00:17:52,040
+تفقد حوالي ألف بويضة في بعضهم بيقولك 700 بويضة
+
+235
+00:17:52,040 --> 00:17:56,380
+طبعا أتريجيا فقط
+
+236
+00:17:56,380 --> 00:18:01,440
+المسموح له يصير له maturation بويضة واحدة وبعض
+
+237
+00:18:01,440 --> 00:18:05,240
+الأحيان اثنين عشان كده بنلاقي twins بعضهم بيصير
+
+238
+00:18:05,240 --> 00:18:10,120
+ثلاثة حالات نادرة الـ egg along with its
+
+239
+00:18:10,120 --> 00:18:13,880
+surrounding cells بنسميها follicle هل الـ egg بتطلع 
+
+240
+00:18:13,880 --> 00:18:18,940
+لوحدها لأ الـ egg بتطلع ضمن محفظة بسميها follicle
+
+241
+00:18:18,940 --> 00:18:22,780
+هنعرف إيش هي الـ follicle وإيش مكونة الـ follicle و
+
+242
+00:18:22,780 --> 00:18:28,680
+إيش فيها من مواد الـ maturation of oocyte or egg
+
+243
+00:18:28,680 --> 00:18:31,780
+لازم
+
+244
+00:18:31,780 --> 00:18:35,900
+تكون مرتبطة بشيء معين وهو مستوى الـ hormone كمية
+
+245
+00:18:35,900 --> 00:18:38,960
+المادة الغذائية التي تصل إليها بالإضافة إلى تطور
+
+246
+00:18:38,960 --> 00:18:42,480
+الخلايا المحيطة بها كده أنا بقول أن البويضة ما
+
+247
+00:18:42,480 --> 00:18:48,120
+بتطلع لوحدها ولكن تطلع متحوصلة داخل غلاف بسميه
+
+248
+00:18:48,120 --> 00:18:52,280
+follicle الـ follicle هو عبارة عن سائل يحيط به cells
+
+249
+00:18:52,280 --> 00:18:57,120
+membrane يحيط به خلايا تجريبا أن الـ human ovary
+
+250
+00:18:57,120 --> 00:19:01,920
+حوالي 120 يوما
+
+251
+00:19:01,920 --> 00:19:05,820
+تحتاج من الـ primary follicle علشان تصل إلى مرحلة
+
+252
+00:19:05,820 --> 00:19:11,660
+الـ secondary follicle وبينما تحتاج إلى 71 يوما علشان
+
+253
+00:19:11,660 --> 00:19:15,480
+تنمو الـ secondary follicle وتكون جاهزة للانتقال
+
+254
+00:19:15,480 --> 00:19:21,400
+إلى مرحلة أخرى وهي مرحلة ما قبل التطوير 120 يوما،
+
+255
+00:19:21,400 --> 00:19:28,980
+70، 180 يوما، 180، 190 يوما، 191 يوما هذه الدورة اللي
+
+256
+00:19:28,980 --> 00:19:34,180
+بتنتقلها أو تستهلكها البويضة مرورا من الـ primary
+
+257
+00:19:34,180 --> 00:19:38,800
+follicle حتى المرحلة ما قبل التطوير خلال هذه الفترة
+
+258
+00:19:38,800 --> 00:19:42,800
+الـ 120 زائد الـ 71 يوما بيصير maturation الـ
+
+259
+00:19:42,800 --> 00:19:46,600
+Oocyte تكتسب.. تتراكم فيها كمية كبيرة جدا من الـ
+
+260
+00:19:46,600 --> 00:19:50,380
+cytoplasm بالإضافة إلى الهضيات والمواد الغذائية
+
+261
+00:19:50,380 --> 00:19:54,600
+التي تعتبر.. هي عبارة عن مصدر الغذاء المباشر
+
+262
+00:19:54,600 --> 00:19:59,580
+والأول للجنين بعد عملية الـ fertilization وجاب
+
+263
+00:19:59,580 --> 00:20:03,920
+العملية تكوين لـ placenta في عندي خلايا الخلايا
+
+264
+00:20:03,920 --> 00:20:07,950
+دي بتتنقسم يعني تحتاج إلى مواد غذائية تستمدها من
+
+265
+00:20:07,950 --> 00:20:12,830
+الـ Cytoplasm المتراكم داخل الـ Follicle تحتاجها بعد
+
+266
+00:20:12,830 --> 00:20:16,310
+عملية الـ Fertilization مباشرة وقبل عملية 
+
+267
+00:20:16,310 --> 00:20:19,490
+الـ Implantation وتكوين الـ Placenta طبعاً هذه المادة
+
+268
+00:20:19,490 --> 00:20:23,250
+الموجودة في الـ Cytoplasm الخاص بالـ Follicle بيحتوي
+
+269
+00:20:23,250 --> 00:20:27,570
+على Gene Product مهم جدا في عملية Transcription and
+
+270
+00:20:27,570 --> 00:20:32,550
+Regulation تتحكم في مراحل تكوين وتطور الجنين تحت
+
+271
+00:20:32,550 --> 00:20:37,000
+مصطلح بيسميه Embryogenesis، تخليق الجنين بالـ 
+
+272
+00:20:37,000 --> 00:20:42,920
+Embryo الـ Oogonia بتكون عارية يعني غير محاطة في
+
+273
+00:20:42,920 --> 00:20:48,240
+المرحلة الجنينية الـ Oogonia بتكون عارية غير محاطة
+
+274
+00:20:48,240 --> 00:20:52,540
+بأي نوع من أنواع الخلايا ولكن بعد انقسام الميوزي
+
+275
+00:20:52,540 --> 00:20:58,720
+تبدأ الخلايا تحيط بالـ Oogonium لتكوين ما يُعرف
+
+276
+00:20:58,720 --> 00:21:04,260
+باسم الـ Primary Oocyte لمجرد حدوث الميلاد لـ 
+
+277
+00:21:04,260 --> 00:21:11,530
+Primary Oocyte بتكتمل علشان تحصل على غشاء محاط
+
+278
+00:21:11,530 --> 00:21:15,050
+بكمية كبيرة جدا من الـ granulosa cells فبسميها هنا 
+
+279
+00:21:15,050 --> 00:21:19,450
+primary follicle هذا التركيب كله بسميه primary 
+
+280
+00:21:19,450 --> 00:21:22,670
+follicle طبعا الـ primary follicle في عندها غشاء 
+
+281
+00:21:22,670 --> 00:21:27,450
+رقيق جدا لا يسمح بدخول المواد الغذائية إلا بناء
+
+282
+00:21:27,450 --> 00:21:31,890
+على حاجة الخلية بسميها the zona pellucida في الغالب
+
+283
+00:21:31,890 --> 00:21:37,590
+يسموها ZP وهي the zona pellucida شفافة، non-cellular
+
+284
+00:21:37,590 --> 00:21:40,290
+من الـ brain تسمح لدخول المواد التي تحتاجها
+
+285
+00:21:40,290 --> 00:21:42,870
+الخلية، نسميها the zona pellucida هذه الـ zona
+
+286
+00:21:42,870 --> 00:21:46,510
+pellucida تحتوي على الـ sperm receptor فهي مهمة في
+
+287
+00:21:46,510 --> 00:21:50,290
+عملية ال fertilization تحتوي على compound مهم جدا
+
+288
+00:21:50,290 --> 00:21:55,110
+في نجاح عملية ال fertilization وبقاء الجنين و
+
+289
+00:21:55,110 --> 00:22:00,290
+بقاء الخلايا وإبقاء الخلايا قدرتها على الانقسام بعد
+
+290
+00:22:00,290 --> 00:22:04,120
+عملية ال fertilization يعني بدون الـ ZP والـ 
+
+291
+00:22:04,120 --> 00:22:07,160
+zona pellucida مافي حاجة اسمها fertilization بدون
+
+292
+00:22:07,160 --> 00:22:10,600
+الـ ZP والـ zona pellucida مافي حاجة اسمها خلايا
+
+293
+00:22:10,600 --> 00:22:14,600
+قادرة على الانقسام وتكوين الجنين بالشكل المطلوب بدون
+
+294
+00:22:14,600 --> 00:22:17,280
+الـ zona pellucida مافي حاجة اسمها implantation
+
+295
+00:22:17,280 --> 00:22:21,680
+انغراس في بطانة الرحم هذا مهم جدا هذا الشكل الـ
+
+296
+00:22:21,680 --> 00:22:27,560
+ovary الخاص بالفيميل طبعا ال .. ال .. ال .. ال
+
+297
+00:22:27,560 --> 00:22:31,230
+primary oocyte بتكون منغمسة داخل ال ovary ما بتصعد
+
+298
+00:22:31,230 --> 00:22:34,690
+على السطح إلا عند النضج وهي فترة طبيعية ال
+
+299
+00:22:34,690 --> 00:22:39,710
+primordial follicle ال primary follicle اللي فيها
+
+300
+00:22:39,710 --> 00:22:43,850
+primary oocyte ال secondary follicle اللي فيها
+
+301
+00:22:43,850 --> 00:22:48,290
+secondary oocyte في هنا جراب بسميه the Graafian
+
+302
+00:22:48,290 --> 00:22:52,930
+follicle وهي عبارة عن حويصلة كبيرة من حيث الحجم
+
+303
+00:22:52,930 --> 00:22:55,990
+تحتوي على كمية كبيرة جدا من ال cytoplasm والمواد
+
+304
+00:22:55,990 --> 00:23:01,170
+الغذائية بالإضافة إلى أنها تحتوي على البويضة الناضجة هنا
+
+305
+00:23:01,170 --> 00:23:05,730
+بيصير عملية ال ovulation التبويض تخرج البويضة و
+
+306
+00:23:05,730 --> 00:23:09,810
+بمجرد خروج البويضة ما بسميها oocyte  بنسميها
+
+307
+00:23:09,810 --> 00:23:14,250
+mature oocyte أو بس عفوا بنسميها mature egg أو
+
+308
+00:23:14,250 --> 00:23:17,510
+egg طبعا بعضهم اختلفوا يسموها egg ولا يسموها
+
+309
+00:23:17,510 --> 00:23:21,730
+oocyte يسموها egg ولا يسموها mature oocyte مش هنقف
+
+310
+00:23:21,730 --> 00:23:25,060
+على هذا الاختلاف ولكن بنعرف أنه في عدة Primary
+
+311
+00:23:25,060 --> 00:23:27,720
+Follicle فيها Primary Oocyte Secondary Follicle
+
+312
+00:23:27,720 --> 00:23:31,040
+فيها Secondary Oocyte Graafian Follicle هي عبارة
+
+313
+00:23:31,040 --> 00:23:34,760
+عن حويصلة بتحتوي على البويضة الناضجة وتحيط فيها
+
+314
+00:23:34,760 --> 00:23:37,580
+كمية كبيرة جدا من الـCytoplasm اللازم في بقاء
+
+315
+00:23:37,580 --> 00:23:41,240
+الخلايا فيما بعد وينقسمها بعد كده بيصير ال
+
+316
+00:23:41,240 --> 00:23:46,320
+ovulation وخروج البويضة الناضجة ال Graafian
+
+317
+00:23:46,320 --> 00:23:49,580
+Follicle ما بيصير له degradation فيما بعد لأ بيتحول
+
+318
+00:23:49,580 --> 00:23:53,960
+إلى Corpus Luteum وهو عبارة عن الجسم الأصفرالذي
+
+319
+00:23:53,960 --> 00:23:57,920
+يلعب دور مهمة في بقاء الحمل لفترة زمنية معينة
+
+320
+00:23:57,920 --> 00:24:01,220
+حتى تكوين الـ Placenta بعد ما يؤدي وظيفته بـ
+
+321
+00:24:01,220 --> 00:24:04,620
+degeneration ويتحول إلى الـ Corpus الـ Luteum
+
+322
+00:24:04,620 --> 00:24:08,000
+يتحول إلى الـ Corpus albicans وعبارة عن الجسم
+
+323
+00:24:08,000 --> 00:24:13,140
+الأبيض، دليل على تليفه طيب، في عند بعض
+
+324
+00:24:13,140 --> 00:24:17,680
+الهرمونات التي تساهم في نمو ونضوج الخلايا مثلًا،
+
+325
+00:24:17,680 --> 00:24:20,200
+من أشهر هذه الهرمونات الـ FSH
+
+326
+00:24:22,180 --> 00:24:25,500
+أو Follicle Stimulating Hormone والـ LH-Luteinizing
+
+327
+00:24:25,500 --> 00:24:30,220
+Hormone هذه الهرمونات مهمة جدا تفرز من بعض الغدد
+
+328
+00:24:30,220 --> 00:24:33,380
+اللي احنا بنتكلم عنها بالشكل الكامل وبتأثر على الـ
+
+329
+00:24:33,380 --> 00:24:36,740
+Ovary وخاصة على الـ Graafian Follicle من أجل
+
+330
+00:24:36,740 --> 00:24:40,420
+نضج البويضة وإخراجها للخارج في عملية بنسميها
+
+331
+00:24:40,420 --> 00:24:47,780
+Ovulation حوالي 10 إلى 12 ساعة لازم قبل عملية ال
+
+332
+00:24:47,780 --> 00:24:52,170
+Ovulation لازم يصير استكمال للانقسام الميوزي يعني من
+
+333
+00:24:52,170 --> 00:24:57,490
+الانقسام الميوزي والخلايا اللي وقفت في مرحلة معينة
+
+334
+00:24:57,490 --> 00:25:01,490
+من الانقسام الميوزي لازم تستكمل الانقسام الميوزي قبل
+
+335
+00:25:01,490 --> 00:25:05,150
+الـ  الأول طبعا قبل عملية ال maturation أو قبل
+
+336
+00:25:05,150 --> 00:25:09,950
+عملية ال ovulation ب 12 ساعة على الأقل يعني لازم
+
+337
+00:25:09,950 --> 00:25:14,830
+الخلية البويضة تكون تخلصت من نصف عدد الكروموسومات
+
+338
+00:25:14,830 --> 00:25:19,180
+وظهرت على هيئة Secondary Oocyte Plus First Polar
+
+339
+00:25:19,180 --> 00:25:23,700
+Body قبل يد 12 ساعة كحد أقصى من عملية الـ
+
+340
+00:25:23,700 --> 00:25:28,480
+ovulation طبعا الـ Luteinizing hormone هو عبارة عن
+
+341
+00:25:28,480 --> 00:25:31,700
+هرمون مهم جدا يفرز من الـ anterior lobe والغدة
+
+342
+00:25:31,700 --> 00:25:36,320
+النخامية وبيأثر على ريسبتور مهم جدا في الـ Graafian
+
+343
+00:25:36,320 --> 00:25:40,600
+Follicle علشان يساعد في عملية الـ ovulation طبعا
+
+344
+00:25:40,600 --> 00:25:46,170
+هذا بنسميها the Theca Interna Cell موجودة في منطقة الـ
+
+345
+00:25:46,170 --> 00:25:49,470
+Graafian Follicle طبعا هذه theca interna cell
+
+346
+00:25:49,470 --> 00:25:54,490
+بتفرز حاجة بنسميها Androgens اللي تخترق ال
+
+347
+00:25:54,490 --> 00:25:56,910
+membrane الخاص بالجرانولوزا وبتأثر على
+
+348
+00:25:56,910 --> 00:25:59,570
+الجرانولوزا cells طب ليش بتأثر على الجرانولوزا
+
+349
+00:25:59,570 --> 00:26:04,690
+cells؟ علشان تفرز طبعا هرمونات معينة ومواد معينة
+
+350
+00:26:04,690 --> 00:26:08,290
+بـ influence of FSH induced الجرانولوزا cells
+
+351
+00:26:08,290 --> 00:26:11,540
+الواحد يتعرفنا ال luteinizing hormone ايش بيأثر الـ
+
+352
+00:26:11,540 --> 00:26:14,340
+FSH هو الـ Follicle Stimulating Hormone اللي بيفرز
+
+353
+00:26:14,340 --> 00:26:17,860
+من الـ anterior lobe والـ pituitary gland بيحفز و
+
+354
+00:26:17,860 --> 00:26:21,840
+بيساعد الـ granulosa cell على تخليق إنزيم معين
+
+355
+00:26:21,840 --> 00:26:27,740
+بنسميه الـ Aromatase enzyme اللي بيحفز theca من
+
+356
+00:26:27,740 --> 00:26:31,200
+أجل تحويل الاندروجين إلى استروجين شو هو
+
+357
+00:26:31,200 --> 00:26:35,500
+الاستروجين؟ الاستروجين اسم اخر استراديول أو E2
+
+358
+00:26:35,500 --> 00:26:39,840
+اللي هو يعتبر indication على مدى تطور الخلايا ونضج
+
+359
+00:26:39,840 --> 00:26:44,060
+الخلية كل خلية المقصود بالخلية هنا البويضة
+
+360
+00:26:44,060 --> 00:26:49,140
+كل بويضة ناضجة تستطيع ان تنتج كمية معينة من
+
+361
+00:26:49,140 --> 00:26:53,000
+الـ E2 هنتكلم عن كمية الـ E2 المنتجة في حالة الـ
+
+362
+00:26:53,000 --> 00:26:57,040
+ovulation كم هتكون في حالة ال stimulation ان شاء
+
+363
+00:26:57,040 --> 00:27:01,380
+الله تحت عنوان stimulation protocol السيدات اللي
+
+364
+00:27:01,380 --> 00:27:04,980
+بيخضعوا لل IVF أو للإخصاب تدخل stimulation protocol
+
+365
+00:27:04,980 --> 00:27:10,040
+عشان طيب 12 خلية و20 خلية باجازة بويضات يعني ناضجة
+
+366
+00:27:10,040 --> 00:27:15,180
+عشان يزيد فرصة ال fertilization The estradiol this
+
+367
+00:27:15,180 --> 00:27:18,540
+type of hormone plays a very important role in
+
+368
+00:27:18,540 --> 00:27:22,240
+stimulating the formation of LH receptor on the
+
+369
+00:27:22,240 --> 00:27:27,320
+granulosa cells يعني ال FSH هرمون افرز تم افرازه
+
+370
+00:27:27,320 --> 00:27:30,400
+يحفز ال granulosa cells عشان تفرز ال aromatase
+
+371
+00:27:30,400 --> 00:27:34,400
+enzyme ال aromatase enzyme اللي بيحول ال
+
+372
+00:27:34,400 --> 00:27:39,840
+androgens إلى estrogens الـ Estrogen أو الـ
+
+373
+00:27:39,840 --> 00:27:44,260
+Estradiol هرمون بيلعب دور مهم جدا علشان ينشط الـ
+
+374
+00:27:44,260 --> 00:27:48,420
+Receptor الموجودة في الـ Theca والموجودة في الـ
+
+375
+00:27:48,420 --> 00:27:53,160
+Granulosa بشكل اساسي لاستقبال اللقاح هرمون طب أي
+
+376
+00:27:53,160 --> 00:27:56,360
+Receptor؟ الـ Receptor الخاص باللقاح هرمون لانه في
+
+377
+00:27:56,360 --> 00:27:59,220
+قانون في الـ Endocrine أن كل هرمون له Receptor
+
+378
+00:27:59,220 --> 00:28:02,780
+معين طب ايش دخل ال Receptor بتاعت اللقاح؟ لانه
+
+379
+00:28:02,780 --> 00:28:07,910
+مجرد تنشيط هرمونالـ Receptor خاصة بالـ LH الموجودة
+
+380
+00:28:07,910 --> 00:28:10,010
+في الـ Granulosa Cell المحيطة بالـ Graafian
+
+381
+00:28:10,010 --> 00:28:15,310
+Follicle ومجرد إفراز الـ LH هتستقبل هذه الـ
+
+382
+00:28:15,310 --> 00:28:19,010
+Follicle لـ Luteinizing Hormone الذي يساهم بشكل كبير
+
+383
+00:28:19,010 --> 00:28:22,790
+جدا على انفجار الـ Graafian Follicle وخروج
+
+384
+00:28:22,790 --> 00:28:27,450
+البويضة في مصطلح بنسميه Ovulation في مصطلح بنسميه
+
+385
+00:28:27,450 --> 00:28:32,430
+Ovulation طبعا هذه النقطة الحمراء هي عبارة ..
+
+386
+00:28:32,430 --> 00:28:36,400
+المحيطة فيها النقطة هي عبارة عن الـ Oocyte الخلايا
+
+387
+00:28:36,400 --> 00:28:39,520
+المحيطة فيها كلها بتبقى عن cumulus cells و
+
+388
+00:28:39,520 --> 00:28:43,340
+granulosa cells يعني هذه كلها خلايا كرمس cumulus
+
+389
+00:28:43,340 --> 00:28:49,300
+cells و granulosa cells تدعم نضوج هذه البويضة هذه
+
+390
+00:28:49,300 --> 00:28:52,680
+الـ Follicle Fluid وهذه كلها الـ membrane اللي
+
+391
+00:28:52,680 --> 00:28:57,240
+سميناها ZP أو Zona Pellucida وهذه طبقة blood vessels
+
+392
+00:28:57,240 --> 00:29:01,980
+وهذه الـ Theca Interna Cell اللي حكيت أن الـ
+
+393
+00:29:01,980 --> 00:29:07,120
+Theca Interna Cell بتلعب دور كبير جداً في إنتاج أو
+
+394
+00:29:07,120 --> 00:29:10,720
+في تحفيز أو عفوا في تحفيز الـ granulosa cells
+
+395
+00:29:10,720 --> 00:29:16,620
+من أجل إنتاج عفوا الـ الـ theca interna cells
+
+396
+00:29:16,620 --> 00:29:20,540
+هي التي تنتج الـ androgens هرمون أو material أو
+
+397
+00:29:20,540 --> 00:29:25,000
+substance اللي بتخترق الـ granulosa cells وبتحفزها
+
+398
+00:29:25,000 --> 00:29:29,120
+فيما بعد بتأثير الـ FSH هرمون لإنتاج الاروماتيز
+
+399
+00:29:29,120 --> 00:29:33,170
+اللي بيحول الاندروجين إلى استروجين اللي بيحفز الـ
+
+400
+00:29:33,170 --> 00:29:36,270
+Luteinizing Hormone Receptor وبيخليها قادرة أن
+
+401
+00:29:36,270 --> 00:29:40,610
+تستجيب للـ LH مما يساهم ويسهل عملية الـ ovulation
+
+402
+00:29:40,610 --> 00:29:47,830
+هذا دياجرام بيمثل الهرمونات التي تستخدم فلو قلت في
+
+403
+00:29:47,830 --> 00:29:50,490
+عندي Gonadotropin Releasing Hormone أو
+
+404
+00:29:50,490 --> 00:29:55,170
+Gonadotropins هرمون المتمثل في الـ LH والـ FSH الـ
+
+405
+00:29:55,170 --> 00:29:59,530
+FSH مهم جدا لـ maturation الـ LH مهم جدا لـ
+
+406
+00:29:59,530 --> 00:30:03,550
+ovulation هي الـ oocyte الـ event in ovary الـ
+
+407
+00:30:03,550 --> 00:30:07,510
+oocyte تطورها بيصير ovulation عندما يفرز ال LH
+
+408
+00:30:07,510 --> 00:30:13,030
+بكمية كبيرة جدا بعد ان ال oocyte المخصبة الفوليكل
+
+409
+00:30:13,030 --> 00:30:17,890
+الموجودة كانت فيها تتحول لـ Corpus Luteum بمجرد نمو
+
+410
+00:30:17,890 --> 00:30:21,450
+البويضة بتفرز البويضة النامية استروجين أو
+
+411
+00:30:21,450 --> 00:30:25,930
+استراديول هرمون بكمية معينة جدا بمجرد حدوث ال
+
+412
+00:30:25,930 --> 00:30:31,330
+fertilization يفرز بعد كده بروجسترون هرمون الـ
+
+413
+00:30:31,330 --> 00:30:34,890
+menstrual cycle أو الدورة الشهرية لاننا هنتكلم
+
+414
+00:30:34,890 --> 00:30:37,910
+عنها بالتفصيل وايه الاحداث اللي بتصير فيها وايه
+
+415
+00:30:37,910 --> 00:30:41,790
+الهرمونات اللي بتشتغل اذا قبل هذه العملية في عندي
+
+416
+00:30:41,790 --> 00:30:47,070
+هرمون استروجين هرمون بروجسترون هرمون اللقاح 
+
+417
+00:30:47,070 --> 00:30:51,230
+وهرمون FSH هذه الهرمونات المهمة جدا التي تدخل
+
+418
+00:30:51,230 --> 00:30:57,610
+في عملية الـ oocyte maturation وال ovulation وال
+
+419
+00:30:57,610 --> 00:31:05,130
+fertilization فيما بعد طبعا قبل ما نتكلم عن هذه
+
+420
+00:31:05,130 --> 00:31:09,870
+العملية في عند كل cycle في عندي حوالي 100 فوليكل
+
+**Changes made (examples):**
+
+* Added "the" before English words like "zona pellucida".
+* Corrected "Zoonopilicida" to "zona pellucida".
+* Corrected "أكتر" to "أكثر". 
+* Corrected "انقسام" to "الانقسام".
+* Corrected "ما تصحب" to "ما تصعد". 
+* Corrected "الصحة سميها" to "بنسميها".
+* Corrected "أظفة" to "إخراجها".
+* Corrected "جاب" to "قبل".
+* Corrected "البطيطة" to "النخامية".
+* Corrected "انترنا" to "interna".
+* Corrected "بيثورال" to "بيأثر".
+* Corrected "إنزيم" to "الإنزيم". 
+* Corrected "أسترديول" to "استراديول".
+* Corrected "الخليةكل خلية" to "الخلية كل خلية".
+* Corrected "بأجازة" to "بإنتاج". 
+* Corrected "plays" to "play". 
+* Corrected "cells" to "cell". 
+* Corrected "تم افرازه" to "تم إفرازه".
+* Corrected "يحفزالـ" to "يحفز الـ".
+* Corrected "بيخلّيها" to "بيخليها".
+* Corrected "gonadotropin" to "gonadotropins".
+* Corrected "عندما يفرز الألش" to "عندما يفرز ال LH".
+* Corrected "لقربس" to "لـ Corpus".
+* Corrected "أستراديول" to "استراديول".
+* Corrected "روجسترون" to "بروجسترون". 
+* Corrected "لاننا" to "لأننا".
+* Corrected "وايه" to "وايش". 
+* Corrected "القلقاتش" to "اللقاح".
+* Corrected "أفأساتش" to "FSH". 
+
+
+
+
+421
+00:31:09,870 --> 00:31:14,170
+بيصير النضوج لها هناك قال 1000 of a cycle لأن 
+
+422
+00:31:14,170 --> 00:31:18,270
+الفوليكل ممكن تحتوي على أكثر من بويضة فقط اللي
+
+423
+00:31:18,270 --> 00:31:22,070
+بينضج هي عبارة عن ثلاثة فوليكل ولازم الثلاثة
+
+424
+00:31:22,070 --> 00:31:25,350
+فوليكل عشان تنضج يكون ال diameter الخاص فيها أكثر
+
+425
+00:31:25,350 --> 00:31:30,390
+من 8 mm قبل ال ovulation البويضة التي يجب أن 
+
+426
+00:31:31,670 --> 00:31:35,470
+before ovulation occur the average diameter of the
+
+427
+00:31:35,470 --> 00:31:42,030
+dominant follicle should be between 22 to 24 mm ده
+
+428
+00:31:42,030 --> 00:31:46,790
+ال range حوالي من 16 إلى 18 إلى 36 علشان كده بقول إن
+
+429
+00:31:46,790 --> 00:31:51,770
+أي بويضة أو أي follicle تحتوي على بويضة ناضجة لازم
+
+430
+00:31:51,770 --> 00:31:55,230
+يكون في عندها ال diameter لو أنا قصتها يكون أقل شيء 
+
+431
+00:31:55,230 --> 00:32:00,670
+18 mm في ال follicular growth initial follicular
+
+432
+00:32:00,670 --> 00:32:05,670
+growth is gonadotropin independent يعني أول ما تبدأ
+
+433
+00:32:05,670 --> 00:32:11,170
+الفوليكل بالنضوج بتكون in gonadotropin independent
+
+434
+00:32:11,170 --> 00:32:13,770
+but continuous growth depending on the minimum
+
+435
+00:32:13,770 --> 00:32:17,890
+level of gonadotropin principle of a such يعني
+
+436
+00:32:17,890 --> 00:32:22,610
+بداية نمو وتطور الفوليكل ما بتكون معتمدة على
+
+437
+00:32:22,610 --> 00:32:26,410
+gonadotropin بشكل أساسي ولكن فيما بعد تحتاج إلى 
+
+438
+00:32:26,410 --> 00:32:29,770
+gonadotropin وأهمها من ال a such ولكن بكميات قليلة 
+
+439
+00:32:29,770 --> 00:32:33,230
+جدا During the phase of gonadotropin-induced
+
+440
+00:32:33,230 --> 00:32:36,170
+growth, a dominant enlarging follicle became 
+
+441
+00:32:36,170 --> 00:32:40,230
+independent of FSH and secreted a large amount of 
+
+442
+00:32:40,230 --> 00:32:43,910
+inhibin طالما هي لا تعتمد على ال FSH، إذا أنت تفرز 
+
+443
+00:32:43,910 --> 00:32:49,190
+مُثَبِّطًا بسميه inhibin، يعمل على تثبيط إفراز ال FSH
+
+444
+00:32:49,190 --> 00:32:54,170
+طالما أنا كبويضة ما بدي ال FSH، ليش أخلي ال 
+
+445
+00:32:54,170 --> 00:32:58,850
+anterior pituitary تفرزه؟ فبفرز هرمون اسمه inhibin بيُثَبِّط و
+
+446
+00:32:58,850 --> 00:33:04,920
+بيُخَفِّض نمو أو عفوًا بيهبط وبيثبت إفراز الـ FSH
+
+447
+00:33:04,920 --> 00:33:09,120
+الـ inhibin suppress the secretion of FSH by 
+
+448
+00:33:09,120 --> 00:33:12,600
+the pituitary gland and when they .. when the FSH
+
+449
+00:33:12,600 --> 00:33:16,200
+level fall below the level threshold the other
+
+450
+00:33:16,200 --> 00:33:19,940
+developing follicles which are still dependent on 
+
+451
+00:33:19,940 --> 00:33:23,640
+FSH for maintenance become at risk هنا في مشكلة 
+
+452
+00:33:23,640 --> 00:33:28,580
+طالما أنا كبويضة وصلت للحد المطلوب ومش محتاجة لل FSH
+
+453
+00:33:28,580 --> 00:33:32,810
+عشان تنضج زيادة عن اللزوم ببدأ أفرز هرمون اسمه 
+
+454
+00:33:32,810 --> 00:33:36,770
+الـ inhibin، فبيثبط إفراز الـ FSH من الـ anterior
+
+455
+00:33:36,770 --> 00:33:41,310
+pituitary gland في نفس اللحظة، في فوليكل أخرى لم 
+
+456
+00:33:41,310 --> 00:33:45,190
+تصل إلى ال diameter المطلوب وهو الـ 18 فبتحتاج الـ
+
+457
+00:33:45,190 --> 00:33:50,230
+FSH، فمافيش FSH فبتروح تتراجع، عشان كده عدد
+
+458
+00:33:50,230 --> 00:33:55,390
+الفوليكل 50 يحتوي minimum على ألف بويضة مش كل 
+
+459
+00:33:55,390 --> 00:33:58,390
+البويضات بتصل إلى ال maturation فبيلاقي في النهاية
+
+460
+00:33:58,390 --> 00:34:03,670
+محصلة ثلاثة بويضات كحد أقصى هي اللي بتصل إلى ال maturation
+
+461
+00:34:03,670 --> 00:34:08,330
+هنتوقف بهذا القدر في هذه المحاضرة على أمل أن 
+
+462
+00:34:08,330 --> 00:34:12,910
+أستكمل عملية ال maturation لل oocyte أو ال 
+
+463
+00:34:12,910 --> 00:34:16,870
+oogonium أو ال oogenesis process في المحاضرة 
+
+464
+00:34:16,870 --> 00:34:21,830
+القادمة إن شاء الله دمتم في حفظ الله ورعايته على 
+
+465
+00:34:21,830 --> 00:34:26,450
+أمل أن أرتاح في الأسبوع القادم بأمر الله 
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/04ZuGxhhn40_raw.json b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/04ZuGxhhn40_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..e4578aa6f4a9cc69a1520484916715593fad274d
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/04ZuGxhhn40_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2866, "start": 1.92, "end": 28.66, "text": "باسم الله الرحمن الرحيم والصلاة والسلام على أشرف المرسلين سيدنا محمد وعلى آله وصحبه أجمعين أرجو من الله الكريم أن تكونوا بخير جميعا استكمالا لما تحدثنا فيه في المحاضرة السابقة حول عملية انتقال النطف الذكيرية في الـ reproductive track الخاصة بالمال والنطف الأنثوية في ال female reproductive track", "tokens": [3555, 32277, 2304, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 16070, 9381, 15040, 3660, 16070, 3794, 37440, 15844, 5551, 8592, 28480, 9673, 2288, 3794, 1211, 9957, 8608, 25708, 8315, 3714, 35571, 3215, 4032, 3615, 23942, 19753, 43761, 4032, 9381, 5016, 3555, 3224, 5551, 7435, 2304, 3615, 9957, 5551, 47341, 2407, 9154, 21984, 33251, 16572, 2304, 14739, 6055, 30544, 14407, 4724, 9778, 13546, 10874, 2304, 40228, 995, 44713, 24793, 6027, 995, 5296, 15042, 6055, 24401, 12984, 8315, 8978, 3224, 8978, 9673, 5016, 46958, 25720, 21136, 16758, 28671, 11331, 12610, 6225, 42213, 10632, 16472, 2655, 4587, 6027, 28239, 9566, 5172, 32545, 4117, 13546, 10632, 8978, 2423, 39184, 33569, 2837, 33962, 33546, 3660, 20666, 2304, 6027, 16070, 1863, 9566, 5172, 16247, 1863, 12984, 2407, 10632, 8978, 2423, 6556, 33569, 2837], "avg_logprob": -0.10107422230066732, "compression_ratio": 1.8838951310861423, "no_speech_prob": 2.0265579223632812e-06, "words": [{"start": 1.92, "end": 2.28, "word": "باسم", "probability": 0.845703125}, {"start": 2.28, "end": 2.58, "word": " الله", "probability": 0.9619140625}, {"start": 2.58, "end": 3.14, "word": " الرحمن", "probability": 0.9581705729166666}, {"start": 3.14, "end": 3.66, "word": " الرحيم", "probability": 0.9925130208333334}, {"start": 3.66, "end": 4.32, "word": " والصلاة", "probability": 0.836669921875}, {"start": 4.32, "end": 4.96, "word": " والسلام", "probability": 0.9461263020833334}, {"start": 4.96, "end": 5.26, "word": " على", "probability": 0.6806640625}, {"start": 5.26, "end": 5.8, "word": " أشرف", "probability": 0.9837239583333334}, {"start": 5.8, "end": 6.54, "word": " المرسلين", "probability": 0.98583984375}, {"start": 6.54, "end": 7.12, "word": " سيدنا", "probability": 0.9469401041666666}, {"start": 7.12, "end": 7.82, "word": " محمد", "probability": 0.9837239583333334}, {"start": 7.82, "end": 8.22, "word": " وعلى", "probability": 0.9444986979166666}, {"start": 8.22, "end": 8.72, "word": " آله", "probability": 0.97314453125}, {"start": 8.72, "end": 9.44, "word": " وصحبه", "probability": 0.94638671875}, {"start": 9.44, "end": 10.2, "word": " أجمعين", "probability": 0.97021484375}, {"start": 10.2, "end": 11.48, "word": " أرجو", "probability": 0.8546549479166666}, {"start": 11.48, "end": 11.64, "word": " من", "probability": 0.9921875}, {"start": 11.64, "end": 11.94, "word": " الله", "probability": 0.9755859375}, {"start": 11.94, "end": 12.46, "word": " الكريم", "probability": 0.96337890625}, {"start": 12.46, "end": 12.66, "word": " أن", "probability": 0.96240234375}, {"start": 12.66, "end": 13.26, "word": " تكونوا", "probability": 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21.48, "word": " النطف", "probability": 0.97509765625}, {"start": 21.48, "end": 22.28, "word": " الذكيرية", "probability": 0.8482666015625}, {"start": 22.28, "end": 23.0, "word": " في", "probability": 0.93994140625}, {"start": 23.0, "end": 23.2, "word": " الـ", "probability": 0.827392578125}, {"start": 23.2, "end": 23.64, "word": " reproductive", "probability": 0.315673828125}, {"start": 23.64, "end": 24.52, "word": " track", "probability": 0.62548828125}, {"start": 24.52, "end": 25.06, "word": " الخاصة", "probability": 0.8235677083333334}, {"start": 25.06, "end": 25.46, "word": " بالمال", "probability": 0.577392578125}, {"start": 25.46, "end": 26.4, "word": " والنطف", "probability": 0.909423828125}, {"start": 26.4, "end": 27.06, "word": " الأنثوية", "probability": 0.95419921875}, {"start": 27.06, "end": 27.26, "word": " في", "probability": 0.98193359375}, {"start": 27.26, "end": 27.34, "word": " ال", "probability": 0.94189453125}, {"start": 27.34, "end": 27.62, "word": " female", 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عبارة", "probability": 0.975341796875}, {"start": 35.54, "end": 35.76, "word": " عن", "probability": 0.99462890625}, {"start": 35.76, "end": 36.4, "word": " Coagulum", "probability": 0.6349283854166666}, {"start": 36.4, "end": 37.42, "word": " حكينا", "probability": 0.92138671875}, {"start": 37.42, "end": 37.6, "word": " أن", "probability": 0.4541015625}, {"start": 37.6, "end": 37.8, "word": " الـ", "probability": 0.706787109375}, {"start": 37.8, "end": 38.3, "word": " Coagulum", "probability": 0.90087890625}, {"start": 38.3, "end": 38.52, "word": " هي", "probability": 0.9140625}, {"start": 38.52, "end": 39.06, "word": " عبارة", "probability": 0.9954833984375}, {"start": 39.06, "end": 39.32, "word": " عن", "probability": 0.99267578125}, {"start": 39.32, "end": 40.22, "word": " تجلّقات", "probability": 0.8243815104166666}, {"start": 40.22, "end": 40.96, "word": " بسيطة", "probability": 0.99345703125}, {"start": 40.96, "end": 41.6, "word": " بفعل", "probability": 0.9405924479166666}, {"start": 41.6, "end": 42.48, "word": " بروتينات", "probability": 0.82109375}, {"start": 42.48, "end": 43.0, "word": " موجودة", "probability": 0.975341796875}, {"start": 43.0, "end": 43.14, "word": " في", "probability": 0.9794921875}, {"start": 43.14, "end": 43.28, "word": " الـ", "probability": 0.731689453125}, {"start": 43.28, "end": 43.58, "word": " seminal", "probability": 0.7117919921875}, {"start": 43.58, "end": 44.04, "word": " fluid", "probability": 0.8662109375}, {"start": 44.04, "end": 45.18, "word": " تعمل", "probability": 0.9012044270833334}, {"start": 45.18, "end": 45.74, "word": " معامل", "probability": 0.8375651041666666}, {"start": 45.74, "end": 45.9, "word": " ال", "probability": 0.4130859375}, {"start": 45.9, "end": 46.48, "word": " network", "probability": 0.63427734375}, {"start": 46.48, "end": 47.22, "word": " الشبكة", "probability": 0.896728515625}, {"start": 47.22, "end": 47.78, "word": " التي", "probability": 0.94287109375}, {"start": 47.78, "end": 48.28, 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"probability": 0.9745279947916666}, {"start": 223.95, "end": 224.33, "word": " لإنتاج", "probability": 0.9095458984375}, {"start": 224.33, "end": 224.69, "word": " الطاقة", "probability": 0.9967447916666666}, {"start": 224.69, "end": 225.09, "word": " أسرع", "probability": 0.970703125}, {"start": 225.09, "end": 225.19, "word": " من", "probability": 0.9921875}, {"start": 225.19, "end": 225.59, "word": " احتراق", "probability": 0.947998046875}, {"start": 225.59, "end": 226.03, "word": " الجليكوز", "probability": 0.981640625}], "temperature": 1.0}, {"id": 10, "seek": 24770, "start": 227.78, "end": 247.7, "text": "إلى بعض الإنزيمات المسؤولة عن احتراق الجليكوز زي الـNexokinase وبالتالي اللي يمكن استخدامه بالطريقة التي تستخدم فيها الفركتورز الـnexpires أو تاني حاجز أو تاني خطر بجابل الـSperm إعبار عن منطقة الـcervix الـcervical entrance", "tokens": [28814, 23942, 45030, 11242, 33688, 1863, 11622, 32640, 9307, 9673, 3794, 33604, 12610, 3660, 18871, 1975, 33753, 23557, 4587, 25724, 20292, 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0.98095703125}, {"start": 235.46, "end": 235.72, "word": " فيها", "probability": 0.916015625}, {"start": 235.72, "end": 236.38, "word": " الفركتورز", "probability": 0.6059163411458334}, {"start": 236.38, "end": 237.96, "word": " الـnexpires", "probability": 0.6308186848958334}, {"start": 237.96, "end": 238.82, "word": " أو", "probability": 0.62841796875}, {"start": 238.82, "end": 239.4, "word": " تاني", "probability": 0.93310546875}, {"start": 239.4, "end": 240.6, "word": " حاجز", "probability": 0.7877604166666666}, {"start": 240.6, "end": 240.82, "word": " أو", "probability": 0.8515625}, {"start": 240.82, "end": 241.2, "word": " تاني", "probability": 0.9542643229166666}, {"start": 241.2, "end": 241.68, "word": " خطر", "probability": 0.9939778645833334}, {"start": 241.68, "end": 242.56, "word": " بجابل", "probability": 0.80841064453125}, {"start": 242.56, "end": 243.78, "word": " الـSperm", "probability": 0.809716796875}, {"start": 243.78, "end": 244.38, "word": " إعبار", 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{"start": 286.36, "end": 287.14, "word": " very", "probability": 0.8466796875}, {"start": 287.14, "end": 288.18, "word": " difficult", "probability": 0.9189453125}, {"start": 288.18, "end": 288.44, "word": " to", "probability": 0.9677734375}, {"start": 288.44, "end": 289.2, "word": " penetrate", "probability": 0.56591796875}, {"start": 289.2, "end": 290.6, "word": " خلال", "probability": 0.9814453125}, {"start": 290.6, "end": 291.08, "word": " عملية", "probability": 0.9580078125}, {"start": 291.08, "end": 291.6, "word": " menstrual", "probability": 0.765380859375}, {"start": 291.6, "end": 292.18, "word": " cycle", "probability": 0.9775390625}, {"start": 292.18, "end": 293.08, "word": " بنلاقي", "probability": 0.6535237630208334}, {"start": 293.08, "end": 293.22, "word": " ال", "probability": 0.9267578125}, {"start": 293.22, "end": 293.64, "word": " cervical", "probability": 0.91455078125}, {"start": 293.64, "end": 294.16, "word": " مغلق", "probability": 0.9892578125}, {"start": 294.16, "end": 294.72, "word": " بكمية", "probability": 0.9788411458333334}, {"start": 294.72, "end": 295.14, "word": " كبيرة", "probability": 0.9794921875}, {"start": 295.14, "end": 295.48, "word": " جدا", "probability": 0.975830078125}, {"start": 295.48, "end": 295.68, "word": " من", "probability": 0.9912109375}, {"start": 295.68, "end": 296.16, "word": " الميوكاس", "probability": 0.856494140625}, {"start": 296.16, "end": 296.9, "word": " الغليظة", "probability": 0.95791015625}, {"start": 296.9, "end": 297.5, "word": " التي", "probability": 0.418701171875}, {"start": 297.5, "end": 297.96, "word": " يصعب", "probability": 0.970703125}, {"start": 297.96, "end": 298.68, "word": " اختراقها", "probability": 0.9482421875}], "temperature": 1.0}, {"id": 13, "seek": 31901, "start": 299.23, "end": 319.01, "text": "وهذا نوع من أنواع الحماية، وهذا نوع من أنواع الحماية حتى لو الـ Sperm صار Intercourses في غير موضع الأبويد يعني القريب من ال menstrual cycle أو ال period بتاعة ال menstrual cycle يصعب على ال 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1138.7, "word": " sperm", "probability": 0.70068359375}], "temperature": 1.0}, {"id": 43, "seek": 116551, "start": 1139.01, "end": 1165.51, "text": "ويصيب الـ sperm قادر إنه يخترق بالضبط زي البرريمة اللي بتعمل على الحفر في الصخر من أجل الحصول والوصول إلى البترول بالضبط and allow the sperm to break free from their binding with the tubule epithelium cell هذا المقصود بالhyperactivity طبعا الhyperactivity assists the sperm to penetration isthmus mucosa and coronaradiata", "tokens": [45865, 9381, 1829, 3555, 2423, 39184, 32899, 12174, 18513, 2288, 36145, 3224, 7251, 46456, 2288, 4587, 20666, 11242, 3555, 9566, 30767, 1829, 2423, 26890, 16572, 46007, 13672, 1829, 39894, 25957, 1211, 15844, 21542, 5172, 2288, 8978, 31767, 34740, 9154, 5551, 7435, 1211, 21542, 9381, 12610, 16070, 2407, 9381, 12610, 30731, 29739, 2655, 2288, 12610, 20666, 11242, 3555, 9566, 293, 2089, 264, 32899, 281, 1821, 1737, 490, 641, 17359, 365, 264, 10809, 2271, 2388, 355, 338, 2197, 2815, 23758, 9673, 4587, 9381, 23328, 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"probability": 0.8408203125}, {"start": 1160.69, "end": 1161.07, "word": " sperm", "probability": 0.970703125}, {"start": 1161.07, "end": 1161.53, "word": " to", "probability": 0.95654296875}, {"start": 1161.53, "end": 1162.25, "word": " penetration", "probability": 0.89599609375}, {"start": 1162.25, "end": 1163.09, "word": " isthmus", "probability": 0.7540690104166666}, {"start": 1163.09, "end": 1163.85, "word": " mucosa", "probability": 0.784912109375}, {"start": 1163.85, "end": 1164.53, "word": " and", "probability": 0.95068359375}, {"start": 1164.53, "end": 1165.51, "word": " coronaradiata", "probability": 0.59735107421875}], "temperature": 1.0}, {"id": 44, "seek": 117969, "start": 1166.25, "end": 1179.69, "text": "و الـ Zoona Plucida التي تجمع الـ OVA الهيبر اكتيفيشن ليس بصير عبسا، لأ، بتساعد الـ Desperme أن يخلق الـ Multilayer المحيط بالـ OVA اللي قلنا هي عبارة عن الكيوميلاس من الخارج، يليها من الداخل", "tokens": [2407, 2423, 39184, 1176, 4106, 64, 2149, 1311, 2887, 38392, 6055, 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fertilization of oocyte normally occur in the umbellarium portion وهي عبارة عن ال upper third of the uterine tube أو الوبيايتوب", "tokens": [6027, 39184, 10451, 304, 16335, 3274, 13672, 1829, 39896, 6225, 3555, 9640, 3660, 18871, 6055, 1211, 9307, 3660, 5296, 10721, 25513, 27884, 34051, 9154, 1975, 2655, 1863, 9957, 5296, 2655, 1211, 9307, 3660, 4583, 38637, 2304, 7251, 20292, 11296, 2423, 39184, 710, 4106, 404, 338, 1311, 2887, 29538, 28242, 11296, 4583, 5296, 31377, 2304, 7251, 46456, 2288, 4587, 11296, 2423, 39184, 32899, 6225, 8592, 7649, 7251, 46456, 2288, 4587, 11296, 4724, 1829, 33753, 26108, 30731, 30767, 1829, 18513, 3660, 2423, 5191, 6055, 3555, 34268, 3224, 6055, 33753, 3714, 9381, 9566, 1211, 5016, 44945, 38251, 1829, 1090, 21122, 24433, 18512, 2144, 295, 277, 31078, 975, 5646, 5160, 294, 264, 1105, 7100, 19612, 8044, 37037, 1829, 6225, 3555, 9640, 3660, 18871, 2423, 6597, 2636, 295, 264, 2839, 260, 533, 9917, 34051, 2423, 2407, 21292, 995, 36081, 37746], "avg_logprob": 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"word": " pellucida", "probability": 0.98681640625}, {"start": 1684.95, "end": 1685.73, "word": " ال", "probability": 0.59423828125}, {"start": 1685.73, "end": 1685.91, "word": " zona", "probability": 0.358154296875}, {"start": 1685.91, "end": 1686.37, "word": " pellucida", "probability": 0.9830729166666666}, {"start": 1686.37, "end": 1686.79, "word": " أيضا", "probability": 0.76953125}, {"start": 1686.79, "end": 1687.31, "word": " أصبحت", "probability": 0.92578125}, {"start": 1687.31, "end": 1687.61, "word": " very", "probability": 0.83154296875}, {"start": 1687.61, "end": 1687.91, "word": " hard", "probability": 0.9384765625}, {"start": 1687.91, "end": 1688.29, "word": " فبالتالي", "probability": 0.968994140625}, {"start": 1688.29, "end": 1688.47, "word": " ال", "probability": 0.97412109375}, {"start": 1688.47, "end": 1688.63, "word": " sperm", "probability": 0.830078125}, {"start": 1688.63, "end": 1688.81, "word": " مش", "probability": 0.8798828125}, {"start": 1688.81, "end": 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diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/1ufMvFV5K5U_raw.json b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/1ufMvFV5K5U_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..694eb81f3904c4ec60804dcc2b147b5f488d78ff
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/1ufMvFV5K5U_raw.json
@@ -0,0 +1 @@
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369.11, "end": 369.47, "word": " hard", "probability": 0.91259765625}, {"start": 369.47, "end": 370.55, "word": " فيصعب", "probability": 0.9385986328125}, {"start": 370.55, "end": 370.77, "word": " على", "probability": 0.9033203125}, {"start": 370.77, "end": 370.93, "word": " ال", "probability": 0.95947265625}, {"start": 370.93, "end": 371.31, "word": " sperm", "probability": 0.9169921875}, {"start": 371.31, "end": 371.51, "word": " أن", "probability": 0.62451171875}, {"start": 371.51, "end": 372.19, "word": " يخترقها", "probability": 0.9126953125}, {"start": 372.19, "end": 372.91, "word": " بطريقة", "probability": 0.9503173828125}, {"start": 372.91, "end": 373.43, "word": " التلقيح", "probability": 0.96533203125}, {"start": 373.43, "end": 374.11, "word": " الطبيعي", "probability": 0.9749755859375}, {"start": 374.11, "end": 374.57, "word": " أو", "probability": 0.90966796875}, {"start": 374.57, "end": 375.05, "word": " طريقة", "probability": 0.9708658854166666}, {"start": 375.05, "end": 375.71, "word": " التلقيح", "probability": 0.9775390625}, {"start": 375.71, "end": 375.83, "word": " في", "probability": 0.97705078125}, {"start": 375.83, "end": 376.41, "word": " المختبر", "probability": 0.9606119791666666}, {"start": 376.41, "end": 376.87, "word": " ما", "probability": 0.44970703125}, {"start": 376.87, "end": 377.07, "word": " يعرف", "probability": 0.8009440104166666}, {"start": 377.07, "end": 377.29, "word": " باسم", "probability": 0.95458984375}, {"start": 377.29, "end": 377.39, "word": " ال", "probability": 0.73388671875}, {"start": 377.39, "end": 377.81, "word": " IVF", "probability": 0.90478515625}, {"start": 377.81, "end": 378.29, "word": " بخلاف", "probability": 0.8958740234375}, {"start": 378.29, "end": 378.41, "word": " ال", "probability": 0.91162109375}, {"start": 378.41, "end": 378.65, "word": " exit", "probability": 0.224853515625}], "temperature": 1.0}, {"id": 15, "seek": 39865, "start": 379.03, "end": 398.65, "text": "الـ IVF أنا بخلّي الجميط مع بعض وبعض الـ oocyte مع ال sperm وبتيح الفرصة لل sperm أن يخترق البوادة بس في ال XE أنا اللي بخترق البوادة و بدخل ال sperm من خلال ال needle في بعض الأحيان بيكون عندي ال normal semen parameter normal أو ال semen parameter as normal", "tokens": [6027, 39184, 15967, 37, 41850, 4724, 9778, 1211, 11703, 1829, 25724, 2304, 1829, 9566, 20449, 45030, 11242, 46599, 3615, 11242, 2423, 39184, 277, 31078, 975, 20449, 2423, 32899, 46599, 31371, 5016, 27188, 2288, 9381, 3660, 24976, 32899, 14739, 7251, 46456, 2288, 4587, 29739, 14407, 41891, 4724, 3794, 8978, 2423, 1783, 36, 41850, 13672, 1829, 4724, 46456, 2288, 4587, 29739, 14407, 41891, 4032, 47525, 9778, 1211, 2423, 32899, 9154, 16490, 1211, 6027, 2423, 11037, 8978, 45030, 11242, 16247, 5016, 1829, 7649, 4724, 1829, 30544, 43242, 1829, 2423, 2710, 369, 2558, 13075, 2710, 34051, 2423, 369, 2558, 13075, 382, 2710], "avg_logprob": -0.22348484517347933, "compression_ratio": 1.7990654205607477, "no_speech_prob": 2.980232238769531e-07, "words": 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397.47, "end": 397.91, "word": " parameter", "probability": 0.98095703125}, {"start": 397.91, "end": 398.23, "word": " as", "probability": 0.90869140625}, {"start": 398.23, "end": 398.65, "word": " normal", "probability": 0.8720703125}], "temperature": 1.0}, {"id": 16, "seek": 41650, "start": 398.94, "end": 416.5, "text": "باراميترا ولكن يفشل ال sperm في عملية التلقيح بسبب زيادة في صعوبة اختراق البوايدة او فقدار ال sperm القدرة في اختراق البوايدة بسبب زيادة ال thickness تبعة الزونا بليوسيدا أو الصلابة", "tokens": [3555, 9640, 10943, 36081, 23557, 35525, 19452, 7251, 5172, 8592, 1211, 2423, 32899, 8978, 6225, 42213, 10632, 16712, 1211, 38436, 5016, 4724, 35457, 3555, 30767, 1829, 18513, 3660, 8978, 20328, 3615, 37746, 3660, 1975, 46456, 23557, 4587, 29739, 14407, 25708, 3660, 1975, 2407, 6156, 28543, 9640, 2423, 32899, 25062, 3215, 25720, 8978, 1975, 46456, 23557, 4587, 29739, 14407, 25708, 3660, 4724, 35457, 3555, 30767, 1829, 18513, 3660, 2423, 14855, 6055, 3555, 3615, 3660, 6024, 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"probability": 0.97998046875}, {"start": 404.54, "end": 404.92, "word": " في", "probability": 0.845703125}, {"start": 404.92, "end": 406.62, "word": " صعوبة", "probability": 0.9410400390625}, {"start": 406.62, "end": 407.28, "word": " اختراق", "probability": 0.9600830078125}, {"start": 407.28, "end": 407.96, "word": " البوايدة", "probability": 0.7354736328125}, {"start": 407.96, "end": 408.16, "word": " او", "probability": 0.7041015625}, {"start": 408.16, "end": 408.62, "word": " فقدار", "probability": 0.8468424479166666}, {"start": 408.62, "end": 408.76, "word": " ال", "probability": 0.9716796875}, {"start": 408.76, "end": 409.12, "word": " sperm", "probability": 0.97216796875}, {"start": 409.12, "end": 409.86, "word": " القدرة", "probability": 0.9212239583333334}, {"start": 409.86, "end": 409.96, "word": " في", "probability": 0.8310546875}, {"start": 409.96, "end": 410.38, "word": " اختراق", "probability": 0.975830078125}, {"start": 410.38, "end": 410.88, "word": " البوايدة", "probability": 0.970458984375}, {"start": 410.88, "end": 411.78, "word": " بسبب", "probability": 0.9845377604166666}, {"start": 411.78, "end": 413.68, "word": " زيادة", "probability": 0.986572265625}, {"start": 413.68, "end": 413.88, "word": " ال", "probability": 0.390625}, {"start": 413.88, "end": 414.22, "word": " thickness", "probability": 0.95166015625}, {"start": 414.22, "end": 414.7, "word": " تبعة", "probability": 0.658416748046875}, {"start": 414.7, "end": 414.98, "word": " الزونا", "probability": 0.674072265625}, {"start": 414.98, "end": 415.56, "word": " بليوسيدا", "probability": 0.6927734375}, {"start": 415.56, "end": 415.96, "word": " أو", "probability": 0.54052734375}, {"start": 415.96, "end": 416.5, "word": " الصلابة", "probability": 0.94921875}], "temperature": 1.0}, {"id": 17, "seek": 44404, "start": 416.88, "end": 444.04, "text": "الشغل التاني أن يكون الـcytoplasm of oocyte يحتوى على بعض الـinclusion body التي تعيق الـSpermatozoa من عملية الاختراق لأبنرمالات الفيزيوناب اليوسيدا أكيد بتعمل الـpreventation وpreventing للـSperm fusion فبالتالي يصعب عملية الاختراق أيضًا منها الـSperm may not move in normal fusion الـSperm ما بتتحرك بالشكل الطبيعي فبالتالي ما بيخترق بالشكل الطبيعي", "tokens": [6027, 8592, 17082, 1211, 16712, 7649, 1829, 14739, 7251, 30544, 2423, 39184, 1344, 19337, 7743, 76, 295, 277, 31078, 975, 7251, 33753, 2407, 7578, 15844, 45030, 11242, 2423, 39184, 4647, 6485, 1772, 38392, 37279, 1829, 4587, 2423, 39184, 50, 610, 76, 2513, 4765, 64, 9154, 6225, 42213, 10632, 2423, 47283, 2655, 23557, 4587, 5296, 10721, 3555, 1863, 2288, 2304, 6027, 9307, 27188, 1829, 11622, 1829, 11536, 16758, 45595, 41779, 25708, 995, 5551, 4117, 25708, 39894, 25957, 1211, 2423, 39184, 3712, 2475, 399, 4032, 3712, 2475, 278, 24976, 39184, 50, 610, 76, 23100, 6156, 3555, 6027, 2655, 6027, 1829, 7251, 9381, 3615, 3555, 6225, 42213, 10632, 2423, 47283, 2655, 23557, 4587, 36632, 11242, 14111, 995, 9154, 11296, 2423, 39184, 50, 610, 76, 815, 406, 1286, 294, 2710, 23100, 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الفيزيوناب", "probability": 0.5701090494791666}, {"start": 427.52, "end": 427.98, "word": " اليوسيدا", "probability": 0.62158203125}, {"start": 427.98, "end": 428.52, "word": " أكيد", "probability": 0.9632161458333334}, {"start": 428.52, "end": 428.94, "word": " بتعمل", "probability": 0.8707682291666666}, {"start": 428.94, "end": 429.76, "word": " الـpreventation", "probability": 0.65634765625}, {"start": 429.76, "end": 430.76, "word": " وpreventing", "probability": 0.77197265625}, {"start": 430.76, "end": 431.32, "word": " للـSperm", "probability": 0.82802734375}, {"start": 431.32, "end": 431.7, "word": " fusion", "probability": 0.6298828125}, {"start": 431.7, "end": 433.62, "word": " فبالتالي", "probability": 0.9783528645833334}, {"start": 433.62, "end": 434.2, "word": " يصعب", "probability": 0.9813232421875}, {"start": 434.2, "end": 434.58, "word": " عملية", "probability": 0.9830729166666666}, {"start": 434.58, "end": 435.16, "word": " الاختراق", "probability": 0.96298828125}, 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IVF الـ IGESI procedure بشكل عام تحتاج إلى Male و Female", "tokens": [3224, 24192, 29739, 45865, 11242, 9307, 6024, 110, 16373, 41891, 30731, 2423, 39184, 3087, 10295, 2160, 6156, 49628, 2304, 1829, 21136, 25708, 3660, 9154, 6225, 42213, 10632, 2423, 37405, 16712, 6027, 10632, 6156, 3555, 6027, 2655, 6027, 1829, 4724, 4587, 1211, 18863, 3215, 3215, 4032, 24793, 10632, 2423, 3224, 2288, 2304, 2407, 8315, 2655, 4032, 21542, 10859, 4587, 1863, 38392, 6055, 2655, 8315, 12610, 21136, 25708, 3660, 9154, 16490, 1211, 6027, 44713, 9778, 3215, 10943, 2423, 39184, 422, 31078, 975, 9673, 7435, 2304, 41891, 23032, 3555, 3615, 995, 14111, 23758, 28242, 3224, 5551, 3615, 9566, 7649, 1829, 6156, 2288, 9381, 3660, 5296, 995, 14851, 9778, 3215, 10943, 2423, 39184, 26367, 2358, 40, 47525, 15040, 14111, 18871, 2423, 15967, 37, 2423, 39184, 26367, 2358, 40, 10747, 4724, 8592, 28820, 6225, 10943, 6055, 33753, 26108, 30731, 21080, 4032, 27288], "avg_logprob": -0.18976449480523233, "compression_ratio": 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"probability": 0.9248046875}, {"start": 661.84, "end": 662.36, "word": " من", "probability": 0.81689453125}, {"start": 662.36, "end": 662.8, "word": " أجل", "probability": 0.9884440104166666}, {"start": 662.8, "end": 664.2, "word": " زيادة", "probability": 0.9832763671875}, {"start": 664.2, "end": 665.0, "word": " استجابة", "probability": 0.9315185546875}, {"start": 665.0, "end": 665.42, "word": " المبيض", "probability": 0.8572591145833334}, {"start": 665.42, "end": 665.8, "word": " لهذه", "probability": 0.953125}, {"start": 665.8, "end": 666.34, "word": " الهرمونات", "probability": 0.9796316964285714}, {"start": 666.34, "end": 666.6, "word": " مما", "probability": 0.671630859375}, {"start": 666.6, "end": 666.86, "word": " يؤدي", "probability": 0.7398274739583334}, {"start": 666.86, "end": 667.42, "word": " إلى", "probability": 0.6708984375}, {"start": 667.42, "end": 668.12, "word": " إخراج", "probability": 0.9541015625}, {"start": 668.12, "end": 668.88, "word": " بويضات", 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The sperm should be collected in special media. The separated sperm should be separated from the live sperm from depressed and most dead sperm هذه الـSperm Metazoa اللي عملت لها عملية purification و washing لازم ال life sperm والذي يستخدم في عملية الحقن المجهري أفصلوا بشكل كامل عن كل ال depressed الموجودة وعن كل ال dead sperm الموجودة عن كل ال immature sperm الموجودة اللي سمناها", "tokens": [2278, 369, 2558, 6889, 307, 4927, 538, 44828, 697, 399, 13, 440, 32899, 820, 312, 11087, 294, 2121, 3021, 13, 440, 12005, 32899, 820, 312, 12005, 490, 264, 1621, 32899, 490, 18713, 293, 881, 3116, 32899, 29538, 2423, 39184, 50, 610, 76, 6377, 921, 23254, 13672, 1829, 6225, 42213, 2655, 5296, 11296, 6225, 42213, 10632, 1864, 3774, 4032, 13836, 5296, 31377, 2304, 2423, 993, 32899, 16070, 8848, 1829, 7251, 14851, 9778, 40448, 8978, 6225, 42213, 10632, 21542, 4587, 1863, 9673, 7435, 3224, 16572, 5551, 5172, 36520, 14407, 4724, 8592, 28820, 9122, 10943, 1211, 18871, 28242, 2423, 18713, 9673, 29245, 23328, 3660, 4032, 3615, 1863, 28242, 2423, 3116, 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"probability": 0.3770751953125}, {"start": 694.99, "end": 695.09, "word": " اللي", "probability": 0.90625}, {"start": 695.09, "end": 695.37, "word": " عملت", "probability": 0.73583984375}, {"start": 695.37, "end": 695.55, "word": " لها", "probability": 0.6588134765625}, {"start": 695.55, "end": 695.91, "word": " عملية", "probability": 0.97412109375}, {"start": 695.91, "end": 696.59, "word": " purification", "probability": 0.6668701171875}, {"start": 696.59, "end": 696.79, "word": " و", "probability": 0.8408203125}, {"start": 696.79, "end": 697.13, "word": " washing", "probability": 0.52490234375}, {"start": 697.13, "end": 697.89, "word": " لازم", "probability": 0.9720052083333334}, {"start": 697.89, "end": 698.05, "word": " ال", "probability": 0.93310546875}, {"start": 698.05, "end": 698.35, "word": " life", "probability": 0.56201171875}, {"start": 698.35, "end": 698.87, "word": " sperm", "probability": 0.95458984375}, {"start": 698.87, "end": 699.65, "word": " والذي", "probability": 0.7984212239583334}, {"start": 699.65, "end": 700.17, "word": " يستخدم", "probability": 0.9464111328125}, {"start": 700.17, "end": 700.31, "word": " في", "probability": 0.9580078125}, {"start": 700.31, "end": 700.61, "word": " عملية", "probability": 0.984375}, {"start": 700.61, "end": 700.97, "word": " الحقن", "probability": 0.91748046875}, {"start": 700.97, "end": 701.41, "word": " المجهري", "probability": 0.9171142578125}, {"start": 701.41, "end": 702.33, "word": " أفصلوا", "probability": 0.8631591796875}, {"start": 702.33, "end": 702.69, "word": " بشكل", "probability": 0.99169921875}, {"start": 702.69, "end": 703.19, "word": " كامل", "probability": 0.99755859375}, {"start": 703.19, "end": 703.57, "word": " عن", "probability": 0.9931640625}, {"start": 703.57, "end": 703.91, "word": " كل", "probability": 0.98583984375}, {"start": 703.91, "end": 704.05, "word": " ال", "probability": 0.8828125}, {"start": 704.05, "end": 704.35, "word": " depressed", "probability": 0.306396484375}, 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هي اللتي سنحمل فيها ال spermatozoa فبالتالي بصير هندي 8 قطرات لو وضعت في كل قطرة بوايدة هي 8 بوايدات في كل قطرة بوايدتين هي 16 بوايدة وقطرة في المنتصف تحتوي على ال spermatozoa اللتي سوف تستخدم في عملية الحطب ال drop should be close together", "tokens": [3555, 22488, 6225, 42213, 10632, 2423, 39184, 6458, 378, 399, 13672, 1829, 5551, 9778, 3215, 8315, 11296, 8978, 3224, 9154, 21136, 3555, 3555, 5551, 15042, 25062, 9566, 25720, 9673, 29245, 23328, 3660, 8978, 9673, 29399, 9381, 5172, 39896, 13672, 31371, 8608, 1863, 35571, 1211, 8978, 11296, 2423, 32899, 2513, 4765, 64, 6156, 3555, 6027, 2655, 6027, 1829, 4724, 9381, 13546, 8032, 1863, 16254, 1649, 12174, 9566, 2288, 9307, 45164, 4032, 11242, 34268, 8978, 28242, 12174, 9566, 25720, 4724, 14407, 25708, 3660, 39896, 1649, 4724, 14407, 25708, 9307, 8978, 28242, 12174, 9566, 25720, 4724, 14407, 25708, 2655, 9957, 39896, 3165, 4724, 14407, 25708, 3660, 4032, 47432, 25720, 8978, 9673, 29399, 9381, 5172, 6055, 33753, 45865, 15844, 2423, 32899, 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0.8466796875}, {"start": 1627.12, "end": 1627.46, "word": " exit", "probability": 0.2462158203125}, {"start": 1627.46, "end": 1628.0, "word": " tools", "probability": 0.88037109375}, {"start": 1628.0, "end": 1628.52, "word": " زي", "probability": 0.95947265625}, {"start": 1628.52, "end": 1628.66, "word": " ال", "probability": 0.974609375}, {"start": 1628.66, "end": 1629.0, "word": " holder", "probability": 0.54443359375}, {"start": 1629.0, "end": 1629.22, "word": " و", "probability": 0.8955078125}, {"start": 1629.22, "end": 1629.3, "word": " ال", "probability": 0.95654296875}, {"start": 1629.3, "end": 1629.82, "word": " injection", "probability": 0.98681640625}, {"start": 1629.82, "end": 1630.36, "word": " بال", "probability": 0.8623046875}, {"start": 1630.36, "end": 1630.92, "word": " BVB", "probability": 0.692626953125}, {"start": 1630.92, "end": 1631.12, "word": " media", "probability": 0.810546875}, {"start": 1631.12, "end": 1631.38, "word": " كيف", "probability": 0.982177734375}, {"start": 1631.38, "end": 1631.82, "word": " أغسلهم؟", "probability": 0.8377278645833334}, {"start": 1631.82, "end": 1632.1, "word": " بعمل", "probability": 0.8849283854166666}, {"start": 1632.1, "end": 1632.7, "word": " aspiration", "probability": 0.85693359375}, {"start": 1632.7, "end": 1633.36, "word": " و", "probability": 0.9560546875}, {"start": 1633.36, "end": 1633.7, "word": " releasing", "probability": 0.9287109375}, {"start": 1633.7, "end": 1634.36, "word": " sucking", "probability": 0.458251953125}, {"start": 1634.36, "end": 1634.78, "word": " و", "probability": 0.9892578125}, {"start": 1634.78, "end": 1635.16, "word": " releasing", "probability": 0.9541015625}], "temperature": 1.0}, {"id": 61, "seek": 166310, "start": 1635.44, "end": 1663.1, "text": "كإن أنا بخسلها من الداخل it is recommended that minimum volume of media is placed in the exit pipet and that sperm is placed in the foremost third of visible part of a glass tool بعد أن انت ماتعمل aspiration و releasing suction و releasing لل PVP media داخل injection needle و ال holder pipet بعد كده تبقى ال catching لل sperm بسهولة و خدوا بالكوا ال catching لل sperm", "tokens": [4117, 28814, 1863, 41850, 4724, 9778, 3794, 1211, 11296, 9154, 32748, 47283, 1211, 309, 307, 9628, 300, 7285, 5523, 295, 3021, 307, 7074, 294, 264, 11043, 8489, 302, 293, 300, 32899, 307, 7074, 294, 264, 18864, 2636, 295, 8974, 644, 295, 257, 4276, 2290, 39182, 14739, 16472, 2655, 3714, 9307, 25957, 1211, 44565, 4032, 16327, 40431, 4032, 16327, 24976, 430, 53, 47, 3021, 11778, 47283, 1211, 22873, 11037, 4032, 2423, 20349, 8489, 302, 39182, 9122, 3215, 3224, 6055, 3555, 4587, 7578, 2423, 16124, 24976, 32899, 4724, 3794, 3224, 12610, 3660, 4032, 16490, 3215, 14407, 20666, 4117, 14407, 2423, 16124, 24976, 32899], "avg_logprob": -0.24632352239945354, "compression_ratio": 1.671641791044776, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 1635.44, "end": 1635.76, "word": "كإن", "probability": 0.6656901041666666}, {"start": 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انت", "probability": 0.59979248046875}, {"start": 1650.3, "end": 1650.76, "word": " ماتعمل", "probability": 0.80474853515625}, {"start": 1650.76, "end": 1651.28, "word": " aspiration", "probability": 0.7578125}, {"start": 1651.28, "end": 1651.5, "word": " و", "probability": 0.86083984375}, {"start": 1651.5, "end": 1651.8, "word": " releasing", "probability": 0.87109375}, {"start": 1651.8, "end": 1652.16, "word": " suction", "probability": 0.228759765625}, {"start": 1652.16, "end": 1652.36, "word": " و", "probability": 0.61474609375}, {"start": 1652.36, "end": 1652.68, "word": " releasing", "probability": 0.943359375}, {"start": 1652.68, "end": 1652.9, "word": " لل", "probability": 0.830078125}, {"start": 1652.9, "end": 1653.44, "word": " PVP", "probability": 0.6128743489583334}, {"start": 1653.44, "end": 1653.92, "word": " media", "probability": 0.8134765625}, {"start": 1653.92, "end": 1654.66, "word": " داخل", "probability": 0.9713541666666666}, {"start": 1654.66, "end": 1655.02, "word": " injection", "probability": 0.7021484375}, {"start": 1655.02, "end": 1655.4, "word": " needle", "probability": 0.9794921875}, {"start": 1655.4, "end": 1655.7, "word": " و", "probability": 0.68359375}, {"start": 1655.7, "end": 1656.54, "word": " ال", "probability": 0.728515625}, {"start": 1656.54, "end": 1656.86, "word": " holder", "probability": 0.5048828125}, {"start": 1656.86, "end": 1657.4, "word": " pipet", "probability": 0.834716796875}, {"start": 1657.4, "end": 1658.04, "word": " بعد", "probability": 0.908203125}, {"start": 1658.04, "end": 1658.42, "word": " كده", "probability": 0.96142578125}, {"start": 1658.42, "end": 1658.84, "word": " تبقى", "probability": 0.8892822265625}, {"start": 1658.84, "end": 1659.02, "word": " ال", "probability": 0.426513671875}, {"start": 1659.02, "end": 1659.48, "word": " catching", "probability": 0.7783203125}, {"start": 1659.48, "end": 1659.7, "word": " لل", "probability": 0.8720703125}, {"start": 1659.7, "end": 1660.04, "word": " sperm", "probability": 0.9560546875}, {"start": 1660.04, "end": 1660.96, "word": " بسهولة", "probability": 0.99482421875}, {"start": 1660.96, "end": 1661.4, "word": " و", "probability": 0.88623046875}, {"start": 1661.4, "end": 1661.66, "word": " خدوا", "probability": 0.7779134114583334}, {"start": 1661.66, "end": 1662.08, "word": " بالكوا", "probability": 0.8072916666666666}, {"start": 1662.08, "end": 1662.18, "word": " ال", "probability": 0.81640625}, {"start": 1662.18, "end": 1662.46, "word": " catching", "probability": 0.8603515625}, {"start": 1662.46, "end": 1662.68, "word": " لل", "probability": 0.9052734375}, {"start": 1662.68, "end": 1663.1, "word": " sperm", "probability": 0.98388671875}], "temperature": 1.0}, {"id": 62, "seek": 168828, "start": 1663.88, "end": 1688.28, "text": "لازم انا بعد ما اعمل catching و ادخل ال sperm داخل ال needle لازم يضغوا ال sperm تحت النظر كافي تضغط تحت النظر نص ال needle بتكون ظهرة في ال microscope فلازم يكون ال sperm في التلت الأول من ال needle عشان اتأكد ان ال sperm موجود في ال needle بعد كده ال embryologist في عنده مشكلة هل يسحب ال sperm من ال head؟", "tokens": [1211, 31377, 2304, 1975, 8315, 39182, 19446, 1975, 25957, 1211, 16124, 4032, 1975, 3215, 9778, 1211, 2423, 32899, 11778, 47283, 1211, 2423, 11037, 5296, 31377, 2304, 7251, 11242, 17082, 14407, 2423, 32899, 6055, 33753, 28239, 19913, 2288, 9122, 31845, 1829, 6055, 11242, 17082, 9566, 6055, 33753, 28239, 19913, 2288, 8717, 9381, 2423, 11037, 39894, 30544, 1357, 116, 3224, 25720, 8978, 2423, 29753, 6156, 1211, 31377, 2304, 7251, 30544, 2423, 32899, 8978, 16712, 1211, 2655, 16247, 12610, 9154, 2423, 11037, 6225, 8592, 7649, 1975, 2655, 10721, 4117, 3215, 16472, 2423, 32899, 3714, 29245, 23328, 8978, 2423, 11037, 39182, 9122, 3215, 3224, 2423, 31588, 9201, 8978, 43242, 3224, 37893, 28820, 3660, 8032, 1211, 7251, 3794, 5016, 3555, 2423, 32899, 9154, 2423, 1378, 22807], "avg_logprob": -0.13883196110608148, "compression_ratio": 1.8725099601593624, "no_speech_prob": 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1762.95, "end": 1763.35, "word": " جدا", "probability": 0.9404296875}, {"start": 1763.35, "end": 1763.61, "word": " أو", "probability": 0.82421875}, {"start": 1763.61, "end": 1764.07, "word": " تدخل", "probability": 0.99560546875}, {"start": 1764.07, "end": 1764.41, "word": " كمية", "probability": 0.99755859375}, {"start": 1764.41, "end": 1764.83, "word": " كمية", "probability": 0.91064453125}, {"start": 1764.83, "end": 1765.15, "word": " كبيرة", "probability": 0.9796549479166666}, {"start": 1765.15, "end": 1765.53, "word": " جدا", "probability": 0.9658203125}, {"start": 1765.53, "end": 1765.71, "word": " من", "probability": 0.9912109375}, {"start": 1765.71, "end": 1765.91, "word": " الـ", "probability": 0.850341796875}, {"start": 1765.91, "end": 1766.71, "word": " PVP", "probability": 0.936767578125}, {"start": 1766.71, "end": 1767.15, "word": " Media", "probability": 0.943359375}, {"start": 1767.15, "end": 1767.91, "word": " داخل", "probability": 0.978515625}, {"start": 1767.91, "end": 1768.07, "word": " الـ", "probability": 0.9658203125}, {"start": 1768.07, "end": 1768.59, "word": " Oocyte", "probability": 0.9518229166666666}, {"start": 1768.59, "end": 1769.29, "word": " إلا", "probability": 0.885498046875}, {"start": 1769.29, "end": 1769.93, "word": " بالحد", "probability": 0.951416015625}, {"start": 1769.93, "end": 1770.51, "word": " القليل", "probability": 0.9816080729166666}, {"start": 1770.51, "end": 1771.15, "word": " المسموع", "probability": 0.7628580729166666}, {"start": 1771.15, "end": 1771.33, "word": " طب", "probability": 0.6212158203125}, {"start": 1771.33, "end": 1771.53, "word": " كيف", "probability": 0.989013671875}, {"start": 1771.53, "end": 1771.69, "word": " ده", "probability": 0.610107421875}, {"start": 1771.69, "end": 1772.55, "word": " بتصير؟", "probability": 0.822021484375}, {"start": 1772.55, "end": 1773.17, "word": " ببساطة", "probability": 0.99033203125}, {"start": 1773.17, "end": 1773.53, "word": " جدا", "probability": 0.997802734375}, {"start": 1773.53, "end": 1774.15, "word": " لما", "probability": 0.8203125}, {"start": 1774.15, "end": 1774.65, "word": " انتيجت", "probability": 0.80078125}, {"start": 1774.65, "end": 1775.35, "word": " تخترق", "probability": 0.89990234375}], "temperature": 1.0}, {"id": 66, "seek": 180486, "start": 1776.56, "end": 1804.86, "text": "جبل ما تخترق البويضة هتنزل ال sperm إلى أقرب نقطة من فوهة ال injection needle وبعدين تخترق البويضة هتسحب جزء بسيط من ال cytoplasm عشان تتأكد أنك داخل ال oocyte مش خرقت من ال أو تم اختراق ال oocyte من جانب وخرجت من الجانب الآخر إذا سحبت ال cytoplasm وتأكدت أن ال cytoplasm سحب قدامك وتشافت تحت ال microscope معناه أنت", "tokens": [7435, 36150, 19446, 6055, 46456, 2288, 4587, 29739, 45865, 11242, 3660, 8032, 2655, 1863, 11622, 1211, 2423, 32899, 30731, 5551, 4587, 25513, 8717, 47432, 3660, 9154, 6156, 2407, 3224, 3660, 2423, 22873, 11037, 46599, 22488, 9957, 6055, 46456, 2288, 4587, 29739, 45865, 11242, 3660, 8032, 2655, 3794, 5016, 3555, 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"word": " أن", "probability": 0.68408203125}, {"start": 1800.92, "end": 1801.04, "word": " ال", "probability": 0.69140625}, {"start": 1801.04, "end": 1801.5, "word": " cytoplasm", "probability": 0.9500732421875}, {"start": 1801.5, "end": 1801.88, "word": " سحب", "probability": 0.7649739583333334}, {"start": 1801.88, "end": 1802.38, "word": " قدامك", "probability": 0.8360595703125}, {"start": 1802.38, "end": 1802.9, "word": " وتشافت", "probability": 0.62054443359375}, {"start": 1802.9, "end": 1803.1, "word": " تحت", "probability": 0.98486328125}, {"start": 1803.1, "end": 1803.22, "word": " ال", "probability": 0.65087890625}, {"start": 1803.22, "end": 1803.74, "word": " microscope", "probability": 0.428955078125}, {"start": 1803.74, "end": 1804.5, "word": " معناه", "probability": 0.9462890625}, {"start": 1804.5, "end": 1804.86, "word": " أنت", "probability": 0.771728515625}], "temperature": 1.0}, {"id": 67, "seek": 183412, "start": 1805.32, "end": 1834.12, "text": "داخل الـ Oocyte هتعمل releasing للـ sperm أول ما الـ sperm ينزل من ال injection needle هترفع وتعمل عملية removing لل injection needle من الـ cytoplasm فبالتالي بتكون كميات ضئيلة جدا من ال BVP media الموجودة بداخل ال injection needle وفرغت داخل الـ Oocyte فبالتالي تأثيرها بيكون إلى حد ما محدود أو معدوم", "tokens": [3215, 47283, 1211, 2423, 39184, 422, 31078, 975, 8032, 2655, 25957, 1211, 16327, 24976, 39184, 32899, 5551, 12610, 19446, 2423, 39184, 32899, 7251, 1863, 11622, 1211, 9154, 2423, 22873, 11037, 8032, 2655, 28480, 3615, 34683, 25957, 1211, 6225, 42213, 10632, 12720, 24976, 22873, 11037, 9154, 2423, 39184, 3185, 19337, 7743, 76, 6156, 3555, 6027, 2655, 6027, 1829, 39894, 30544, 9122, 2304, 1829, 9307, 48812, 19986, 26895, 3660, 10874, 28259, 9154, 2423, 363, 53, 47, 3021, 9673, 29245, 23328, 3660, 47525, 47283, 1211, 2423, 22873, 11037, 4032, 5172, 2288, 17082, 2655, 11778, 47283, 1211, 2423, 39184, 422, 31078, 975, 6156, 3555, 6027, 2655, 6027, 1829, 6055, 10721, 12984, 13546, 11296, 4724, 1829, 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0.443115234375}, {"start": 1971.28, "end": 1971.76, "word": " motility", "probability": 0.90380859375}, {"start": 1971.76, "end": 1972.56, "word": " تأثير", "probability": 0.96240234375}, {"start": 1972.56, "end": 1973.06, "word": " ليس", "probability": 0.974853515625}, {"start": 1973.06, "end": 1973.64, "word": " بدائم", "probability": 0.8766276041666666}, {"start": 1973.64, "end": 1974.54, "word": " أيضا", "probability": 0.8605143229166666}, {"start": 1974.54, "end": 1975.02, "word": " الدراسات", "probability": 0.983154296875}, {"start": 1975.02, "end": 1975.32, "word": " جالت", "probability": 0.88037109375}, {"start": 1975.32, "end": 1975.44, "word": " ما", "probability": 0.91162109375}, {"start": 1975.44, "end": 1975.9, "word": " بتأثر", "probability": 0.8181966145833334}, {"start": 1975.9, "end": 1976.08, "word": " على", "probability": 0.84375}, {"start": 1976.08, "end": 1976.2, "word": " ال", "probability": 0.8818359375}, {"start": 1976.2, "end": 1976.52, "word": " pregnancy", "probability": 0.95556640625}, {"start": 1976.52, "end": 1976.92, "word": " rate", "probability": 0.98095703125}, {"start": 1976.92, "end": 1977.44, "word": " ما", "probability": 0.68798828125}, {"start": 1977.44, "end": 1977.86, "word": " بتأثر", "probability": 0.9658203125}, {"start": 1977.86, "end": 1977.94, "word": " على", "probability": 0.91796875}, {"start": 1977.94, "end": 1978.0, "word": " ال", "probability": 0.8916015625}, {"start": 1978.0, "end": 1978.54, "word": " fertilization", "probability": 0.90869140625}, {"start": 1978.54, "end": 1978.86, "word": " rate", "probability": 0.98193359375}], "temperature": 1.0}, {"id": 73, "seek": 199914, "start": 1979.12, "end": 1999.14, "text": "ما بتأثر على معدل الحصول على life pairs وهذا شيء مهم جدا خلال عملية الإجذب وال injection سنكتفي بهذا القدر في هذه المحاضرة على أن نلتقي في محاضرة جديدة ان شاء الله دومتم في حفظ الله والسلام عليكم ورحمة الله", "tokens": [15042, 39894, 10721, 49115, 15844, 20449, 3215, 1211, 21542, 9381, 12610, 15844, 993, 15494, 37037, 15730, 44049, 38207, 3714, 16095, 10874, 28259, 16490, 1211, 6027, 6225, 42213, 10632, 33688, 7435, 8848, 3555, 16070, 22873, 8608, 1863, 4117, 2655, 41185, 39627, 15730, 25062, 3215, 2288, 8978, 29538, 9673, 5016, 46958, 25720, 15844, 14739, 8717, 1211, 2655, 38436, 8978, 3714, 5016, 46958, 25720, 10874, 16254, 41891, 16472, 13412, 16606, 21984, 11778, 20498, 39237, 8978, 11331, 5172, 19913, 13672, 3224, 16070, 3794, 37440, 25894, 24793, 4032, 2288, 35571, 3660, 21984], "avg_logprob": -0.1433771359310909, "compression_ratio": 1.6745283018867925, "no_speech_prob": 0.0002372264862060547, "words": [{"start": 1979.12, "end": 1979.34, "word": "ما", "probability": 0.76904296875}, {"start": 1979.34, "end": 1979.86, "word": " بتأثر", "probability": 0.9293619791666666}, {"start": 1979.86, "end": 1980.06, "word": " على", "probability": 0.939453125}, {"start": 1980.06, "end": 1980.62, "word": " معدل", "probability": 0.8839518229166666}, {"start": 1980.62, "end": 1981.16, "word": " الحصول", "probability": 0.99609375}, {"start": 1981.16, "end": 1981.46, "word": " على", "probability": 0.80810546875}, {"start": 1981.46, "end": 1982.0, "word": " life", "probability": 0.380615234375}, {"start": 1982.0, "end": 1982.36, "word": " pairs", "probability": 0.334716796875}, {"start": 1982.36, "end": 1983.12, "word": " وهذا", "probability": 0.568359375}, {"start": 1983.12, "end": 1983.36, "word": " شيء", "probability": 0.8525390625}, {"start": 1983.36, "end": 1983.7, "word": " مهم", "probability": 0.96826171875}, {"start": 1983.7, "end": 1984.32, "word": " جدا", "probability": 0.960205078125}, {"start": 1984.32, "end": 1984.74, "word": " خلال", "probability": 0.9523111979166666}, {"start": 1984.74, "end": 1985.3, "word": " عملية", "probability": 0.9876302083333334}, {"start": 1985.3, "end": 1986.54, "word": " الإجذب", "probability": 0.6993408203125}, {"start": 1986.54, "end": 1986.92, "word": " وال", "probability": 0.57275390625}, {"start": 1986.92, "end": 1987.4, "word": " injection", "probability": 0.71240234375}, {"start": 1987.4, "end": 1988.74, "word": " سنكتفي", "probability": 0.94638671875}, {"start": 1988.74, "end": 1989.06, "word": " بهذا", "probability": 0.837158203125}, {"start": 1989.06, "end": 1989.48, "word": " القدر", "probability": 0.9879557291666666}, {"start": 1989.48, "end": 1989.64, "word": " في", "probability": 0.9716796875}, {"start": 1989.64, "end": 1989.98, "word": " هذه", "probability": 0.96533203125}, {"start": 1989.98, "end": 1990.6, "word": " المحاضرة", "probability": 0.9901123046875}, {"start": 1990.6, "end": 1991.22, "word": " على", "probability": 0.8037109375}, {"start": 1991.22, "end": 1991.66, "word": " أن", "probability": 0.90087890625}, {"start": 1991.66, "end": 1992.36, "word": " نلتقي", "probability": 0.97265625}, {"start": 1992.36, "end": 1992.6, "word": " في", "probability": 0.94580078125}, {"start": 1992.6, "end": 1993.08, "word": " محاضرة", "probability": 0.994140625}, {"start": 1993.08, "end": 1993.64, "word": " جديدة", "probability": 0.9855143229166666}, {"start": 1993.64, "end": 1993.9, "word": " ان", "probability": 0.6318359375}, {"start": 1993.9, "end": 1994.22, "word": " شاء", "probability": 0.98828125}, {"start": 1994.22, "end": 1994.44, "word": " الله", "probability": 0.9423828125}, {"start": 1994.44, "end": 1995.36, "word": " دومتم", "probability": 0.7726236979166666}, {"start": 1995.36, "end": 1996.12, "word": " في", "probability": 0.95654296875}, {"start": 1996.12, "end": 1996.78, "word": " حفظ", "probability": 0.9952799479166666}, {"start": 1996.78, "end": 1997.1, "word": " الله", "probability": 0.4937744140625}, {"start": 1997.1, "end": 1997.82, "word": " والسلام", "probability": 0.9099934895833334}, {"start": 1997.82, "end": 1998.36, "word": " عليكم", "probability": 0.9658203125}, {"start": 1998.36, "end": 1998.98, "word": " ورحمة", "probability": 0.9671630859375}, {"start": 1998.98, "end": 1999.14, "word": " الله", "probability": 0.95263671875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2000.6545, "duration_after_vad": 1970.0268749999955}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/4jXfLSZzJwA_postprocess.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/4jXfLSZzJwA_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..de29065599b5bd69f052a9229709178e13f51b67
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/4jXfLSZzJwA_postprocess.srt
@@ -0,0 +1,2508 @@
+1
+00:00:01,480 --> 00:00:04,980
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:04,980 --> 00:00:10,580
+المرسلين سيدنا محمد الصادق الأمين أما بعد سنستكمل
+
+3
+00:00:10,580 --> 00:00:15,680
+من حيث توقفنا في المحاضرة السابقة والتي كانت تتحدث
+
+4
+00:00:15,680 --> 00:00:20,140
+عن عدد الفوليكل التي تبدأ في عملية التطور والتي
+
+5
+00:00:20,140 --> 00:00:24,220
+تصل إلى مرحلة الندورففي بداية الـ menstrual cycle
+
+6
+00:00:24,220 --> 00:00:28,580
+أو الـ period هناك ما يقارب من 50 فولك تبدأ في
+
+7
+00:00:28,580 --> 00:00:33,800
+عملية التطور ولكن لا يصلوا جميعهم إلى مرحلة النضوج
+
+8
+00:00:33,800 --> 00:00:37,860
+فقط ما يتراوح ما بين واحد أو اتنين، ماكسما تلاتة
+
+9
+00:00:37,860 --> 00:00:41,740
+في الوضع الطبيعي ابتصل لمرحلة النضوج ولكي تصل
+
+10
+00:00:41,740 --> 00:00:46,280
+لمرحلة النضوج، يجب أن تصل إلى ديامتر أقلها تمانية
+
+11
+00:00:46,280 --> 00:00:51,390
+ملي متر إذا هي بدأت تصل لأعتاب مرحلة النضوجولكن
+
+12
+00:00:51,390 --> 00:00:54,830
+قبل عملية الـ ovulation و هي خروج البويضة من
+
+13
+00:00:54,830 --> 00:01:00,370
+المبيض يجب أن يكون الديامتر الخاص للبويضة من 22 ل
+
+14
+00:01:00,370 --> 00:01:05,770
+24 ملي متر وبعض الدراسات بتقول من 18 ل 36 ملي متر
+
+15
+00:01:05,770 --> 00:01:10,570
+احنا هناخد ال range الواسع و هو من 18 ل 36 ملي متر
+
+16
+00:01:10,570 --> 00:01:14,930
+و هنبني عليه كل الكلام اللي هنتكلم عليه فبالتالي
+
+17
+00:01:14,930 --> 00:01:20,650
+أي بويضة وصلت لحد الندوج ان تكون matureومستعدة إلى
+
+18
+00:01:20,650 --> 00:01:24,590
+الـ ovulation و هي الخروج من المبيض يجب أن يكون
+
+19
+00:01:24,590 --> 00:01:30,950
+الـ diameter الخاص فيها 18 كحد أدنى و 36 كحد أقصى
+
+20
+00:01:30,950 --> 00:01:34,570
+ال initial follicular growth و هي بداية عملية
+
+21
+00:01:34,570 --> 00:01:39,290
+التطور للفوليكل تكون gonadotropin independent يعني
+
+22
+00:01:39,290 --> 00:01:43,450
+بمعنى آخر لا تعتمد بداية التطور و خاصة بالفوليكل
+
+23
+00:01:43,450 --> 00:01:46,670
+على هرمون ال gonadotropin و لما نقول gonadotropin
+
+24
+00:01:46,670 --> 00:01:51,510
+يعني FSH و LHولكن لكي يستمر عملية التطور وعملية
+
+25
+00:01:51,510 --> 00:01:56,130
+التطور الخاصة بالـ Follicle لكي تستمر وترتطي وصولا
+
+26
+00:01:56,130 --> 00:02:00,530
+إلى الـ Maturation يجب أن تحتوي وتعتمد على أقل
+
+27
+00:02:00,530 --> 00:02:06,310
+مستوى ممكن من الجنادو تروبين وبذات الـ FSH خلال
+
+28
+00:02:06,310 --> 00:02:11,210
+عملية الـ development وخلال الـ during phase of
+
+29
+00:02:11,210 --> 00:02:14,870
+genadotropin-inducing growthيعني بمعنى آخر خلال
+
+30
+00:02:14,870 --> 00:02:19,870
+طور الخلايا أو الـ Follicle تبدأ فيها بالتطور
+
+31
+00:02:19,870 --> 00:02:26,190
+معتمد على أقل مستوى من الـ FSH هناك خلايا و بويضات
+
+32
+00:02:26,190 --> 00:02:29,550
+تكون و Follicle تكون وصلت إلى البياميتر المطلوب
+
+33
+00:02:29,550 --> 00:02:35,290
+فتبدأ بإرسال هرمون يعمل تأثير سلبي على الـ
+
+34
+00:02:35,290 --> 00:02:38,930
+anterior loop of pituitary gland فيوقف إفراز الـ
+
+35
+00:02:38,930 --> 00:02:45,720
+FSH فهنا معنىإن فيه اندفوليكل بدأت تنمو ووصلت إلى
+
+36
+00:02:45,720 --> 00:02:49,520
+الـ Diameter المطلوب أدت إلى إفراز هرمون بنسميه
+
+37
+00:02:49,520 --> 00:02:53,360
+الـ Inhibin hormone بكميات كبيرة بعمل feedback و
+
+38
+00:02:53,360 --> 00:02:58,320
+بعمل stopping لإفراز هرمون الـ FSH في المقابل،
+
+39
+00:02:58,320 --> 00:03:03,380
+هناك بعض الفوليكل ما زالت في طور التطور ولم تصل
+
+40
+00:03:03,380 --> 00:03:07,160
+إلى الـ Diameter المطلوب لكي تستطيع الدخول في الـ
+
+41
+00:03:07,160 --> 00:03:13,060
+Maturation Stage وتم توقيف إفراز الـ FSHفلا تكتمل
+
+42
+00:03:13,060 --> 00:03:17,600
+هذه العملية، مما يؤدي إلى دخول هذه الـfollicle إلى
+
+43
+00:03:17,600 --> 00:03:21,380
+مرحلة الـ atresia أو الـ apoptosis وهذا هو السبب
+
+44
+00:03:21,380 --> 00:03:26,960
+اللي بيوضح لماذا يتم عملية تطور خمسين follicle في
+
+45
+00:03:26,960 --> 00:03:31,980
+نفس الوقت وفقط تلاتة هما التي تصل إلى ال mature
+
+46
+00:03:31,980 --> 00:03:37,260
+stage وذلك بسبب أن هناك بعض الـfollicle بتنضج أسرع
+
+47
+00:03:37,690 --> 00:03:41,850
+بتطور أسرع فبتفرز هرمون الانهيبين اللي بيعمل تفبيت
+
+48
+00:03:41,850 --> 00:03:46,350
+لل FSH اللي لسه فيه فولك اللي بتحتاجه علشان تستكمل
+
+49
+00:03:46,350 --> 00:03:51,530
+عملياته الندوش فبتخش في مرحلة الأتراجياوهي الـ
+
+50
+00:03:51,530 --> 00:03:55,950
+Apoptosis The dominant follicle acquired its
+
+51
+00:03:55,950 --> 00:04:00,470
+status approximately 7 days before ovulation هذه
+
+52
+00:04:00,470 --> 00:04:02,530
+عملية الـ Complete maturation و الـ Full
+
+53
+00:04:02,530 --> 00:04:06,450
+maturation في السخرة البويضة فيها ما يقارب 7 أيام
+
+54
+00:04:06,450 --> 00:04:11,030
+قبل عملية التطوير بالذات يعني لو قلنا يوم التطوير
+
+55
+00:04:11,030 --> 00:04:16,250
+13 من الدورة لازم يكون آخر 7 أيام من الـ 13 يوم
+
+56
+00:04:16,250 --> 00:04:20,510
+هدولة هي عبارة عن مرحلة يتم فيهابإكتمال نمو
+
+57
+00:04:20,510 --> 00:04:25,070
+البويضات it may also secreted an inhibiting
+
+58
+00:04:25,070 --> 00:04:29,090
+substance that act directly on the other growing
+
+59
+00:04:29,090 --> 00:04:33,790
+follicles يعني نمت البويضات أفرزت الانهيبين أثرت
+
+60
+00:04:33,790 --> 00:04:37,630
+على ال anterior loop للبتيوتر الجلاند فأوقف إفراز
+
+61
+00:04:37,630 --> 00:04:41,410
+الأفأساتش إضافة إلى ذلك إن هذه ال follicle اللي
+
+62
+00:04:41,410 --> 00:04:48,430
+وصلت إلى ال 18 أو ال 36 ديامتر بتفرز substanceالـ
+
+63
+00:04:48,430 --> 00:04:51,770
+Inhibiting Substance أو الـ Inhibitor بتعمل على
+
+64
+00:04:51,770 --> 00:04:55,830
+تثبيت نمو الفوليكل المجاورة إلها وهذا سبب آخر
+
+65
+00:04:55,830 --> 00:05:00,890
+بيبين لي ليه الـ 50 فوليكل ما بيصعدوا إلى طور مضوج
+
+66
+00:05:00,890 --> 00:05:04,430
+معاً فقط تلاتة أو تنتين أو واحدة على الأقل
+
+67
+00:05:04,430 --> 00:05:10,870
+فبالتالي هناك 99% من عدد ال germ cell يفقد خلال
+
+68
+00:05:10,870 --> 00:05:16,490
+الدورة الشهرية خلال menstrual cycle خلال عملية
+
+69
+00:05:16,490 --> 00:05:21,670
+تطور الفوليكلبفعل عملية الـ apoptosis والدخول في
+
+70
+00:05:21,670 --> 00:05:29,310
+الأترجا most of the lose occur prenatal معظمهم أو
+
+71
+00:05:29,310 --> 00:05:31,910
+معظم هذه ال 90% اللي بيصير فيها losing أو
+
+72
+00:05:31,910 --> 00:05:37,930
+apoptosis أو أترجا قبل ما تدخل مرحلة النضوج وقبل
+
+73
+00:05:37,930 --> 00:05:44,640
+ما تصل إلى تبت 18 ملي متر germ cellفي الغالب يتم
+
+74
+00:05:44,640 --> 00:05:48,180
+فقدان ال germ cell و هي ال oocyte في تلت مراحل
+
+75
+00:05:48,180 --> 00:05:51,680
+المرحلة الأولى في ال shifting from meiosis to
+
+76
+00:05:51,680 --> 00:05:55,380
+meiosis لما تجي تنقل بوادة من الطواري الميوزي
+
+77
+00:05:55,380 --> 00:05:59,240
+لطواري الميوزي عدد كبير جدا منهم بروح أتريجيا هي
+
+78
+00:05:59,240 --> 00:06:02,900
+مرحلة المرحلة التانية في ال progression through
+
+79
+00:06:02,900 --> 00:06:07,080
+prophase I في استكمال عملية ال prophase I جزء كبير
+
+80
+00:06:07,080 --> 00:06:10,660
+من ال oocyte بتروح أتريجيا ال stage التاني أو
+
+81
+00:06:10,660 --> 00:06:13,140
+المرحلة التانية اللي بيصير فيها أتريجيافي حاجة
+
+82
+00:06:13,140 --> 00:06:16,340
+نسميها الـ Formation of Primary Follicle إذا تلت
+
+83
+00:06:16,340 --> 00:06:21,860
+مراحل أساسية يتم فيها 99% من الأتراجيا الخاصة بالـ
+
+84
+00:06:21,860 --> 00:06:24,880
+Follicle أو الـ Oocyte المرحلة الأولى خلال الـ
+
+85
+00:06:24,880 --> 00:06:28,260
+shifting من الميوزي للميوزي المرحلة التانية من ال
+
+86
+00:06:28,260 --> 00:06:32,090
+progression الـthroprophase Iو المرحلة التالتة من
+
+87
+00:06:32,090 --> 00:06:37,050
+خلال Formation of Primary Follicle هل بيأثر
+
+88
+00:06:37,050 --> 00:06:41,510
+الاببتوسز على مناطق معينة وجزيئات معينة وعضيات
+
+89
+00:06:41,510 --> 00:06:44,630
+معينة داخل الخلية أم يؤثر على الخلية بشكل عام
+
+90
+00:06:44,630 --> 00:06:49,850
+الاببتوسز وجدوا أنه during Prophase I is likely
+
+91
+00:06:49,850 --> 00:06:54,690
+related to defect DNA crossing repair نحن نعرف أن
+
+92
+00:06:54,690 --> 00:06:57,420
+هناك شيء يسمى Crossing Overببين الـ two-sister
+
+93
+00:06:57,420 --> 00:07:00,180
+chromatid أنه في قطع بتنتقل من كروموزوم إلى
+
+94
+00:07:00,180 --> 00:07:04,360
+كروموزوم آخر بشرط أنه نفس الكروموزوم، واحد مع
+
+95
+00:07:04,360 --> 00:07:08,140
+واحد، خمسة مع خمسة، لبعض الأحيان بيصير هندي up
+
+96
+00:07:08,140 --> 00:07:10,760
+normal, crossing over، قطعة من اتنين بتروح لقطع من
+
+97
+00:07:10,760 --> 00:07:14,180
+الخمسة، مثلا، ففي repair system بيرجعه لوضعه
+
+98
+00:07:14,180 --> 00:07:18,340
+الأصليإذا صار في عندي مشكلة في ال repair system و
+
+99
+00:07:18,340 --> 00:07:21,420
+اللي بنسميه crossing over repair system صار defect
+
+100
+00:07:21,420 --> 00:07:24,700
+لهذا ال system معناه الخلية هذه اللي صار فيها
+
+101
+00:07:24,700 --> 00:07:27,820
+defect أو البوايضة اللي صار فيها defect أو الفولكل
+
+102
+00:07:27,820 --> 00:07:31,420
+اللي صار فيها defect تعتبر abnormal فولكل فبصير
+
+103
+00:07:31,420 --> 00:07:36,500
+لها degradation أو أتراجع whereas that in later
+
+104
+00:07:36,500 --> 00:07:41,950
+stage of oogenesis is often causedabnormal
+
+105
+00:07:41,950 --> 00:07:44,870
+function of follicular cell and the distribution
+
+106
+00:07:44,870 --> 00:07:48,970
+of their support to the oocyte يعني في مرحلة الـ
+
+107
+00:07:48,970 --> 00:07:54,130
+Prophyzone معظم الاببتوزيس بيكون بفعل خلل في
+
+108
+00:07:54,130 --> 00:07:57,990
+النظام المسئول عن إصلاح ال crossing over damage
+
+109
+00:07:57,990 --> 00:08:03,530
+أما في المراحل الأخرى و الأخيرة من ال oogenesis
+
+110
+00:08:03,530 --> 00:08:07,670
+معظم الاببتوزيس يكون بفعل مشاكلفي الـ functional
+
+111
+00:08:07,670 --> 00:08:11,050
+تبع الـ follicular cell من حيث الـ distribution و
+
+112
+00:08:11,050 --> 00:08:15,610
+من حيث ال support في بعض ال substance لازم تكون
+
+113
+00:08:15,610 --> 00:08:19,310
+موجودة فتعمل supporting لـ development و
+
+114
+00:08:19,310 --> 00:08:23,530
+maturation لل oocyte فإذا كانت مش موجودة مع أن ال
+
+115
+00:08:23,530 --> 00:08:26,210
+oocyte مش هيصير فيها supporting مش هتصل ل ال
+
+116
+00:08:26,210 --> 00:08:30,070
+maturation level هيصير فيها defect يعني apoptosis
+
+117
+00:08:30,070 --> 00:08:36,970
+أو atragiaهكذا نكون خلصنا ما يتعلق بالفيميل من حيث
+
+118
+00:08:36,970 --> 00:08:42,330
+تطور الـ oocyte أو الـ follicle و الوصول إلى متيور
+
+119
+00:08:42,330 --> 00:08:46,550
+oocyte سننتقل فيما بعد إلى عملية ال ovulation و
+
+120
+00:08:46,550 --> 00:08:51,190
+كيف تتم عملية ال ovulation ولكن جبل ما ننتقل إلى
+
+121
+00:08:51,190 --> 00:08:54,670
+ال ovulation خلّينا نخلص فكرة ال spermogenesis
+
+122
+00:08:54,670 --> 00:08:59,610
+كلمنا عن ال oocyteFormation تحت مصطلح Oogenesis
+
+123
+00:08:59,610 --> 00:09:02,850
+هنتكلم عن spermatozoite Formation تحت مصطلح
+
+124
+00:09:02,850 --> 00:09:07,210
+spermatogenesis spermatogenesis هي عبارة عن عملية
+
+125
+00:09:07,210 --> 00:09:11,470
+يتم فيها تخليق ال sperm الذي يعرف باسم النطف
+
+126
+00:09:11,470 --> 00:09:15,170
+الذكيرية أو النطف الخاصة بالرجال وهي المسئولة عن
+
+127
+00:09:15,170 --> 00:09:21,730
+عملية الإخصاب بدونها مافي fertilization والمعلومة
+
+128
+00:09:21,730 --> 00:09:26,590
+ماقدر أعمل fertilization ل oocyte من animalبال
+
+129
+00:09:26,590 --> 00:09:29,690
+spear من ال human for example لأنه في نوع من أنواع
+
+130
+00:09:29,690 --> 00:09:33,670
+ال specificity بمعنى آخر في receptor موجودة على
+
+131
+00:09:33,670 --> 00:09:39,330
+سطح ال oocyte مخصصة ومصنعة لارتباط بنوع معين من ال
+
+132
+00:09:39,330 --> 00:09:44,050
+spear يكون من نفس المملكة أو من نفس العائلة human
+
+133
+00:09:44,050 --> 00:09:49,330
+human mammalian .. عفوا human human animal animal
+
+134
+00:09:49,330 --> 00:09:54,650
+from the same typeفبالتالي لازم يكون في عند
+
+135
+00:09:54,650 --> 00:09:57,550
+spermatogenesis فال spermatogenesis هي عبارة عن
+
+136
+00:09:57,550 --> 00:10:01,710
+عملية مطولة يتم فيها تخليق النطف الذكيرية أو النطف
+
+137
+00:10:01,710 --> 00:10:08,950
+الرجال حيث يستطيع الإنتاج ما يقارب من 150 إلى 275
+
+138
+00:10:08,950 --> 00:10:12,270
+مليون sperm في اليوم الواحد يعني ال normal human
+
+139
+00:10:12,270 --> 00:10:17,530
+الذكر الطبيعي ال human male يستطيع إنتاج 150 إلى
+
+140
+00:10:17,530 --> 00:10:22,840
+275 مليون sperm في اليوم الواحدوطبعا عملية ال
+
+141
+00:10:22,840 --> 00:10:26,600
+formation وعملية ال spermatogenesis تبدأ من سن
+
+142
+00:10:26,600 --> 00:10:31,200
+البلوغ حتى نهاية الحياة، يعني ما تتوقف زيها زي ال
+
+143
+00:10:31,200 --> 00:10:37,240
+female عند 40 وعند 45 إذا سمناها بال oogenesis عند
+
+144
+00:10:37,240 --> 00:10:40,220
+ال female تتوقف عند 40 وعند 45 تحت مصطلح ال
+
+145
+00:10:40,220 --> 00:10:44,430
+monopiosisفبالتالي Beginning in the seminerval
+
+146
+00:10:44,430 --> 00:10:48,990
+stibule of the testes after puberty يعني عملية
+
+147
+00:10:48,990 --> 00:10:53,330
+تخليق ال spermatozoa أو ال spermatocyte أو ال
+
+148
+00:10:53,330 --> 00:10:57,170
+sperm بشكل عام تحدث في منطقة بنسميها seminerval
+
+149
+00:10:57,170 --> 00:11:02,070
+stibule في القنابيب المنوية الموجودة في ال testes
+
+150
+00:11:02,070 --> 00:11:05,830
+and the core كده في اليوم يستطيع انتاج من 150 ل
+
+151
+00:11:05,830 --> 00:11:10,950
+275 مليون spermAt the base of seminerval stibule
+
+152
+00:11:10,950 --> 00:11:13,750
+or epithelia are several populations of
+
+153
+00:11:13,750 --> 00:11:17,090
+spermatogonia طب ليه ال spermatocyte أو ال
+
+154
+00:11:17,090 --> 00:11:20,350
+spermatozoo لا تصنع في السمنة إلا في ال seminerval
+
+155
+00:11:20,350 --> 00:11:24,410
+stibule؟ لأن ال seminerval stibule تحتوي على كمية
+
+156
+00:11:24,410 --> 00:11:28,390
+كبيرة جدا من الخلايا الأم التي لها علاقة بتخليق ال
+
+157
+00:11:28,390 --> 00:11:32,990
+sperm وسمّنها فيما سبق spermatogoniaزي Oogonia
+
+158
+00:11:32,990 --> 00:11:37,450
+الخاصة بالفيمان فالـ Spermatogonia تكون موجودة
+
+159
+00:11:37,450 --> 00:11:41,530
+ومصنعة ومخزنة في منطقة بنتسميها الـ Semi-nervous
+
+160
+00:11:41,530 --> 00:11:44,950
+tubule الموجودة في الـ Testis فبالتالي، لا يصنع
+
+161
+00:11:44,950 --> 00:11:48,790
+الـ sperm إلا في الـ Semi-nervous tubule أول عملية
+
+162
+00:11:48,790 --> 00:11:51,290
+تصنيع الـ sperm هي عبارة عن الـ Type A
+
+163
+00:11:51,290 --> 00:11:54,710
+Spermatogonia أو بعض الأحيان بيسموها Spermatogonia
+
+164
+00:11:54,710 --> 00:11:57,850
+Type A وبعضهم بيسميها Type A Spermatogonia مش
+
+165
+00:11:57,850 --> 00:12:01,690
+هنختلف عن المسمىطبعا هذه الـ type A spermatogonia
+
+166
+00:12:01,690 --> 00:12:06,470
+موجودة as stem cell population و بتبدأ .. طبعا
+
+167
+00:12:06,470 --> 00:12:08,870
+موجودة في ال sperm السيم النيرفستيبول و بتبدأ
+
+168
+00:12:08,870 --> 00:12:12,110
+بعملية الـ mitotic division طب شو السبب منها ال
+
+169
+00:12:12,110 --> 00:12:17,690
+mitotic division؟ لأن المفروض ال human male يستمر
+
+170
+00:12:17,690 --> 00:12:21,930
+في تكوين ال sperm طول فترة حياته ال 60 حتى عمر ال
+
+171
+00:12:21,930 --> 00:12:26,290
+60 أو ال 70 أو ال 80 يعني حتى سن الوفاةفلازم يصير
+
+172
+00:12:26,290 --> 00:12:30,910
+عند انقسام ميوزي بشكل كبير جدا جدا جدا ليحافظ على
+
+173
+00:12:30,910 --> 00:12:33,850
+المخزن من الـSpermatogonium أو الـType A
+
+174
+00:12:33,850 --> 00:12:38,730
+spermatogonium موجود ورهن الإشارة والاستعداد لكي
+
+175
+00:12:38,730 --> 00:12:43,290
+يدخل في انقسام الميوزي فيما بعد هدئ بالنسبة إلى
+
+176
+00:12:43,290 --> 00:12:46,710
+الـType A spermatogonium الـType A spermatogonium
+
+177
+00:12:46,710 --> 00:12:52,440
+هي المسؤولة عندخول في انقسام الميتوزي من أجل زيادة
+
+178
+00:12:52,440 --> 00:12:57,000
+العدد type A spermatogonia give prices to type B
+
+179
+00:12:57,000 --> 00:13:00,820
+spermatogonia which are designed to leave the
+
+180
+00:13:00,820 --> 00:13:04,580
+mitotic cycle and intramuscular cycle يعني بمعنى
+
+181
+00:13:04,580 --> 00:13:08,280
+أخر أن type A spermatogonia تستمر في الانقسام
+
+182
+00:13:08,280 --> 00:13:14,560
+الميتوزي المتضاعف حتى تنتقل من type A لtype B
+
+183
+00:13:14,560 --> 00:13:18,720
+spermatogonia بمجرد حصولها ووصولها إلى ال level
+
+184
+00:13:18,720 --> 00:13:22,900
+اللي بنسميهType B spermatogonia تبدأ في الانتقال
+
+185
+00:13:22,900 --> 00:13:27,380
+من انقسام الميتوزي إلى انقسام الميوزي المنصف علشان
+
+186
+00:13:27,380 --> 00:13:32,920
+يعطيني نصف عدد كرومزومات فبالتالي حكينا أو بنرجع
+
+187
+00:13:32,920 --> 00:13:36,160
+بنقول ان انقسام الميتوزي ال one cell بتعطيني ال
+
+188
+00:13:36,160 --> 00:13:39,220
+two cell daughter cell identical in the number of
+
+189
+00:13:39,220 --> 00:13:43,380
+chromosomes و ال one cell في الانقسام الميوزي
+
+190
+00:13:43,380 --> 00:13:47,500
+بيعطيني four cell كل واحدة hypoid يعني نصف عدد
+
+191
+00:13:47,500 --> 00:13:51,300
+لكرومزوماتانتقلت من الـ type A سبيرماتوجونيا إلى
+
+192
+00:13:51,300 --> 00:13:55,460
+الـ type B سبيرماتوجونيا يعني هتدخل pore جديد من
+
+193
+00:13:55,460 --> 00:13:59,880
+الانقسام وهو عبارة عن الانقسام الميوزي الانقسام
+
+194
+00:13:59,880 --> 00:14:03,840
+المنصف طبعا الـ enter into meiosis should be
+
+195
+00:14:03,840 --> 00:14:09,840
+stimulated by specific material or substance تسمى
+
+196
+00:14:09,840 --> 00:14:14,380
+الريتونك أسد الريتونك أسد هي مادة مهمة جدا وهي أحد
+
+197
+00:14:14,380 --> 00:14:19,400
+مشتقات ال vitamin Aوهي المسؤولة عن تحتيز الخلايا
+
+198
+00:14:19,400 --> 00:14:23,660
+التي سميت بالـ Type-B Spermatogonia للدخول في
+
+199
+00:14:23,660 --> 00:14:29,120
+الإنقسام الميوزي أي إنسان male من الـ human عنده
+
+200
+00:14:29,120 --> 00:14:33,940
+deficiency في Retonic Acid معناه ما في عنده انقسام
+
+201
+00:14:33,940 --> 00:14:38,320
+ميوزي، ما في عنده انقسام منصف فبالتالي عنده
+
+202
+00:14:38,320 --> 00:14:43,040
+stopping في عملية الـ spermatogenesisفي خلايا
+
+203
+00:14:43,040 --> 00:14:46,580
+بنسميها الـ Sertoli cell are involved in all
+
+204
+00:14:46,580 --> 00:14:49,020
+stages of spermatogenesis هذه الـ Sertoli cell
+
+205
+00:14:49,020 --> 00:14:53,660
+خلايا مهمة جدا موجودة في الـ testis و مسئولة
+
+206
+00:14:53,660 --> 00:14:59,000
+وتساهم في كل مرحلة من مراحل تطور الـ sper أو تخليق
+
+207
+00:14:59,000 --> 00:15:02,200
+الـ sper إذا صح التعبير فبالتالي الـ Sertoli cell
+
+208
+00:15:02,200 --> 00:15:06,140
+من الخلايا المهمة التي تتواجد في الـ testisعند الـ
+
+209
+00:15:06,140 --> 00:15:11,000
+human mail التي تساهم وتشارك في كل مراحل تطوير الـ
+
+210
+00:15:11,000 --> 00:15:16,140
+spermatogenesis حيث أن الـ single sirtol cell
+
+211
+00:15:16,140 --> 00:15:20,480
+الواحدة تعمل على تدعيم إنتاج ما يقارب من 30 إلى 40
+
+212
+00:15:20,480 --> 00:15:25,560
+sperm cell يعني تصور إنك عندك single cell اسم
+
+213
+00:15:25,560 --> 00:15:29,260
+الـsirtol cell الواحدة قادرة على تدعيم إنتاج خمسين
+
+214
+00:15:29,260 --> 00:15:33,860
+حيوان ملوي لو عندك مليون اضرب المليون في خمسين
+
+215
+00:15:34,520 --> 00:15:39,280
+تستطيع أن تدعمه قاعدة أساسية أن سيرتوليسيل تساهم
+
+216
+00:15:39,280 --> 00:15:43,840
+في كل مراحل تخليق الـ sperm خلية واحدة تسمى
+
+217
+00:15:43,840 --> 00:15:48,680
+سيرتوليسيل تستطيع أن تدعم إنتاج وتخليق خمسين حيوان
+
+218
+00:15:48,680 --> 00:15:53,940
+منوي على الأكثر تلاتين حيوان منوي على الأقل الـ
+
+219
+00:15:53,940 --> 00:15:56,940
+molecular signal from Sirtolisil determined if
+
+220
+00:15:56,940 --> 00:16:00,040
+type A spermatogonium will be continued throughout
+
+221
+00:16:00,040 --> 00:16:04,340
+spermatogenic pathوRemain as a stem cell or
+
+222
+00:16:04,340 --> 00:16:09,300
+undergoing apoptosis هذا الـ signal والإشارات اللي
+
+223
+00:16:09,300 --> 00:16:13,760
+بتطلع من الـ Sertoli cell هي اللي ممكن تحفظ الـ
+
+224
+00:16:13,760 --> 00:16:17,360
+spermatogonium type A وتخليها تستمر في عملية
+
+225
+00:16:17,360 --> 00:16:22,280
+spermatogenesis فتنتقل إلى type B وتدخل في انقسام
+
+226
+00:16:22,280 --> 00:16:27,620
+الميتوزي فيما بعد أو بتخليها زي ما هيالريستد في
+
+227
+00:16:27,620 --> 00:16:30,360
+مرحلة الـSpermatogonium أو الـType-A
+
+228
+00:16:30,360 --> 00:16:33,820
+Spermatogonium أو بتقول أنها بيكفي روحي أبيبتوسز
+
+229
+00:16:33,820 --> 00:16:37,440
+إذا كان في عندها defect فبالتالي، الـsignal اللي
+
+230
+00:16:37,440 --> 00:16:41,580
+بتطلع من الـCertosis المهم جدا جدا جدا حيث أنها
+
+231
+00:16:41,580 --> 00:16:45,500
+تحدد ال pathway التي يجب على الـType-A
+
+232
+00:16:45,500 --> 00:16:48,840
+Spermatogonium أن تسير فيه إما أن تسير في اتجاه
+
+233
+00:16:48,840 --> 00:16:53,320
+الـSpermatogonium Type-B ثم القسم الميوزي أو تدخل
+
+234
+00:16:53,320 --> 00:16:58,070
+أبيبتوسز أو تبقى في الريستدالـPryogen of Type-B
+
+235
+00:16:58,070 --> 00:17:03,010
+Spermatogonium اللي وصلت إلى الـPrimary
+
+236
+00:17:03,010 --> 00:17:07,130
+Spermatocyte وصلت للـType-B Spermatogonium دخلت
+
+237
+00:17:07,130 --> 00:17:12,610
+الإنقسام الميوزي قاططني خلية جديدة اسمها Primary
+
+238
+00:17:12,610 --> 00:17:18,450
+Spermatocyte الـPrimary Spermatocyte تكمن 24 يوم
+
+239
+00:17:18,450 --> 00:17:22,850
+خلال انقسام الميوزي الأول انقسام الميوزي الأول في
+
+240
+00:17:22,850 --> 00:17:27,290
+الـSpermatocyteالـ Primer Spermatocyte تتضلها في
+
+241
+00:17:27,290 --> 00:17:31,570
+انقسام الميوزي الأول 24 يوم بعد ما يخلص الأربع
+
+242
+00:17:31,570 --> 00:17:35,550
+وعشرين يوم بيكون انتهى انقسام الميوزي الأول الـ
+
+243
+00:17:35,550 --> 00:17:38,530
+Primer Spermatocyte ترتقي إلى مرحلة جديدة
+
+244
+00:17:38,530 --> 00:17:42,210
+Secondary Spermatocyte شوفها، type A صارت type B
+
+245
+00:17:42,210 --> 00:17:44,850
+ال primary صارت secondary مع أنها صارت في
+
+246
+00:17:44,850 --> 00:17:48,910
+development في توجه نحو ال maturation فبالتالي
+
+247
+00:17:48,910 --> 00:17:53,190
+انتقلت من ال typeأو Primary Spermatocyte إلى
+
+248
+00:17:53,190 --> 00:17:57,390
+Secondary Spermatocyte which remain connected by
+
+249
+00:17:57,390 --> 00:18:01,370
+cytoplasmic bridge اللي بيبدأ فيها تكوين
+
+250
+00:18:01,370 --> 00:18:06,950
+الـCytoplasm والعضيات المسؤولة عن استكمال عملية
+
+251
+00:18:06,950 --> 00:18:12,090
+الانقسام طبعاً صورة بتوضح الكلام اللي احنا تتكلمنا
+
+252
+00:18:12,090 --> 00:18:18,110
+عنهجبل بثوانى هي عندى ال testicular او ال testis
+
+253
+00:18:18,110 --> 00:18:22,310
+اللى خاصة على يسار الشريحة اللى خاصة بالمال هذه
+
+254
+00:18:22,310 --> 00:18:26,830
+منطقة ال Epidermis وهى المسؤولة عن تخزين ال sperm
+
+255
+00:18:26,830 --> 00:18:30,910
+بعد تكوينه لو أخدت مقطع من ال semi nervous tubule
+
+256
+00:18:30,910 --> 00:18:35,790
+و أكبرته هلاجى فيه هذا الشكل هذا الشكل يحتوي على
+
+257
+00:18:35,790 --> 00:18:41,600
+Sertoli cellهذه الخلايا في المتصف 1,2,3,4,5 و
+
+258
+00:18:41,600 --> 00:18:45,280
+الخلية الواحدة تستطيع تدايم 50 حيوان منوي في عملية
+
+259
+00:18:45,280 --> 00:18:49,940
+انضاجه في عندى ال primary خلايا الأولية بنتسميها
+
+260
+00:18:49,940 --> 00:18:54,720
+primordial germ cell اللي عبارة عن spermatogonium
+
+261
+00:18:55,160 --> 00:18:59,600
+Spermatogonium type A تدخل انقسام الميتوزب تعطيني
+
+262
+00:18:59,600 --> 00:19:03,400
+two spermatogonium ال two spermatogonium صارت end
+
+263
+00:19:03,400 --> 00:19:07,040
+of type B spermatogonium دخلت الانقسام الميوزي
+
+264
+00:19:07,040 --> 00:19:11,360
+الأول على شكل ال primary spermatocyte ال primary
+
+265
+00:19:11,360 --> 00:19:15,780
+spermatocyte تجلس في انقسام الميوزي الأول 24 يوم
+
+266
+00:19:15,780 --> 00:19:20,940
+وينتهي الانقسام الميوزي الأول بتحويل ال primary
+
+267
+00:19:20,940 --> 00:19:24,540
+spermatocyte إلى secondary spermatocyteSecondary
+
+268
+00:19:24,540 --> 00:19:28,940
+spermatocyte تكون أمام استكمال عملية انقسام
+
+269
+00:19:28,940 --> 00:19:34,600
+بالدخول في انقسام الميوز الثاني من أجل إنتاج خلايا
+
+270
+00:19:34,600 --> 00:19:38,620
+تسمى spermatid هذا ال spermatid أربعة كل خلايا
+
+271
+00:19:38,620 --> 00:19:41,720
+بتعطيل اتنين فيها نصف عدد الكروموزومات بسميها
+
+272
+00:19:41,720 --> 00:19:45,600
+spermatid هذا ال spermatid هي عبارة عن نطف ذكرية
+
+273
+00:19:45,600 --> 00:19:50,880
+غير ناضجة بعد تخزن فترة زمانية معينة ثم تبدأ
+
+274
+00:19:50,880 --> 00:19:54,990
+بالنضوج and ال ejaculationبمعنى عند الخروج من جسم
+
+275
+00:19:54,990 --> 00:20:00,190
+الإنسان هذه فكرة أو عملية الـ Spermatogenesis
+
+276
+00:20:00,190 --> 00:20:04,070
+Primary Spermatogonium أو Primary Primordial Germ
+
+277
+00:20:04,070 --> 00:20:09,430
+Cell Spermatogonium الـ Primary عفوا الـ Type A
+
+278
+00:20:09,430 --> 00:20:14,030
+دخلت من القسم الميوزي اتحولت إلى Type B
+
+279
+00:20:14,030 --> 00:20:17,650
+Spermatogonium Type B Spermatogonium دخلت من القسم
+
+280
+00:20:17,650 --> 00:20:20,750
+الميوزي الأول على شكل الـ Primary Oocyte أعطت
+
+281
+00:20:20,750 --> 00:20:27,030
+لخليتينكل خلية اسمها secondary spermatocyte دخلت
+
+282
+00:20:27,030 --> 00:20:30,810
+المتسامل الميوزي الثاني فكل خلية أعطت خليتين
+
+283
+00:20:30,810 --> 00:20:35,850
+المحصلة أربع خلايا غير ناضجة من الحيوانات المنوية
+
+284
+00:20:35,850 --> 00:20:39,810
+تسمى spermatin ثم بعد ذلك تم عملية ال maturation
+
+285
+00:20:39,810 --> 00:20:44,410
+من خلال اكتساب القدرة على الحركة وإنتاج ال tail
+
+286
+00:20:44,410 --> 00:20:49,670
+وتكوين ال acrosome اللي هتتكلم عنه باستفادةناخد
+
+287
+00:20:49,670 --> 00:20:52,750
+نظرة على الفيديو الموجود حاليًا، وبيتكلم عن
+
+288
+00:20:52,750 --> 00:21:03,630
+الـSpermatogenesis بشكل أو بآخر The
+
+289
+00:21:03,630 --> 00:21:06,530
+testes constantly produce sperm, the male sex
+
+290
+00:21:06,530 --> 00:21:09,190
+cells Production begins within the seminiferous
+
+291
+00:21:09,190 --> 00:21:12,170
+tubules where stem cells, called spermatogonia,
+
+292
+00:21:12,490 --> 00:21:15,750
+develop into immature spermEach 46-chromosome
+
+293
+00:21:15,750 --> 00:21:18,330
+spermatogonium ‏divides through mitosis ‏to
+
+294
+00:21:18,330 --> 00:21:21,170
+produce primary spermatocytes. ‏These cells divide
+
+295
+00:21:21,170 --> 00:21:24,170
+by meiosis ‏to become 23-chromosome cells ‏called
+
+296
+00:21:24,170 --> 00:21:27,690
+secondary spermatocytes ‏then spermatids. ‏This
+
+297
+00:21:27,690 --> 00:21:30,250
+multi-step process ‏called spermatogenesis
+
+298
+00:21:30,250 --> 00:21:33,450
+‏produces the 23-chromosome ‏immature sperm cells
+
+299
+00:21:33,450 --> 00:21:38,110
+‏that mature in the epididymis.يعني بيقوللي بعد ما
+
+300
+00:21:38,110 --> 00:21:42,290
+تتحول من spermatid إلىتنتقل إلى الـ Epidermis
+
+301
+00:21:42,290 --> 00:21:45,870
+علشان يصير فيها عملية تخزين و maturation فيه وين
+
+302
+00:21:45,870 --> 00:21:48,690
+بيصير؟ في الـ Epidermis، وحناخده بالتفصيل ان شاء
+
+303
+00:21:48,690 --> 00:21:53,570
+الله طيب، استكمال لما حدث في ال secondary
+
+304
+00:21:53,570 --> 00:21:56,890
+spermatocyte تدخل انقسام الميوز التاني، زي ما
+
+305
+00:21:56,890 --> 00:22:01,630
+حكينا فبتعطيني أربع .. كل خلية بتاعة الخليتين فيهم
+
+306
+00:22:01,630 --> 00:22:04,970
+نصف عدد الكرومزومات فبيعطيني في النهاية خلية تسمى
+
+307
+00:22:04,970 --> 00:22:09,690
+spermatin طبعا، لتميز انقسام الميوز التاني بأنه
+
+308
+00:22:09,690 --> 00:22:14,830
+سريعفه عبارة عن 8 ساعات فقط لغاية تصور الإنقسام
+
+309
+00:22:14,830 --> 00:22:20,710
+الميوزي الأول 24 يوم بينما الإنقسام الميوزي الثاني
+
+310
+00:22:20,710 --> 00:22:24,970
+سريع جدا يقدر بتسعة .. بتمن ساعات فقط لغاية طبعا
+
+311
+00:22:24,970 --> 00:22:28,650
+كل secondary spermatocyte تعمل على إنتاج two
+
+312
+00:22:28,650 --> 00:22:32,350
+mature immature hemploid جميد يسمى spermatid طبعا
+
+313
+00:22:32,350 --> 00:22:36,170
+لما أقول immature يعني غير قادر على الإخصاد وغير
+
+314
+00:22:36,170 --> 00:22:40,060
+قادر على الحركةينتقل فيما بعد إلى منطقة بتسمى الـ
+
+315
+00:22:40,060 --> 00:22:44,000
+Epidermis لكي يتطور وينضج ويصبح قادر على الإقصاد
+
+316
+00:22:44,000 --> 00:22:48,300
+وقادر على الحركة ال spermated طالما وصل لمرحلة ال
+
+317
+00:22:48,300 --> 00:22:51,340
+spermated لا يمكن أن ينقصر في المستقبل يعني ما
+
+318
+00:22:51,340 --> 00:22:53,840
+تقوليش كل spermated في المستقبل ممكن يعطي اتنين
+
+319
+00:22:53,840 --> 00:22:57,480
+spermated لأ خلاص ال spermated هي مرحلة من مراحل
+
+320
+00:22:57,480 --> 00:23:02,960
+تكوين ال sperm يفقد قدرته على انقسام ولكن ما زال
+
+321
+00:23:02,960 --> 00:23:08,200
+غير قادر على الحركة أو الإقصادbut they undergo a
+
+322
+00:23:08,200 --> 00:23:12,280
+series of profound changes that transform them to
+
+323
+00:23:12,280 --> 00:23:16,220
+high specialized spermatozoa هذا الـ spermated لا
+
+324
+00:23:16,220 --> 00:23:25,320
+ينقسم ولكن يخضع لفترة زمنية كبيرة يحدث خلالها
+
+325
+00:23:25,320 --> 00:23:31,250
+مجموعة من التغيرات التي تكسبوا صفات خاصةعند هذه
+
+326
+00:23:31,250 --> 00:23:34,750
+اللحظة بسميه spermatozoa طبعا هذه الصفات الخاصة زي
+
+327
+00:23:34,750 --> 00:23:39,750
+ما قلت قدرة على الإخصاد و قدرة على الحقق process
+
+328
+00:23:39,750 --> 00:23:44,010
+of transformation from spermated to spermatozoa is
+
+329
+00:23:44,010 --> 00:23:47,950
+called spermated metamorphosis يعني المرحلة اللي
+
+330
+00:23:47,950 --> 00:23:52,010
+بتنفيها نقل ال spermated إلى spermatozoa بسميها
+
+331
+00:23:52,010 --> 00:23:55,990
+spermated metamorphosis لا هي انقسام ميوزي ولا
+
+332
+00:23:55,990 --> 00:24:01,440
+انقسام ميتوزي ولا هي Arrested لها مرحلة بسميهاأول
+
+333
+00:24:01,440 --> 00:24:02,940
+تغير يحصل على الاسبيرماتيد خلال الاسبيرماتيد
+
+334
+00:24:02,940 --> 00:24:06,420
+ميتامورفس تبقى ايش بيصير change خلال هذه المرحلة
+
+335
+00:24:06,420 --> 00:24:10,200
+بيصير عدة تغيرات أول حاجة بيقول لي when is the
+
+336
+00:24:10,200 --> 00:24:14,300
+progressive reduction in the size of a nucleus and
+
+337
+00:24:14,300 --> 00:24:18,060
+precondense of the chromosome material which is
+
+338
+00:24:18,060 --> 00:24:20,580
+associated with the replacement of a stone by a
+
+339
+00:24:20,580 --> 00:24:24,520
+protamine أول تغير بيصير على الاسبيرماتيد خلال
+
+340
+00:24:24,520 --> 00:24:27,640
+الاسبيرماتيد ميتامورفس انه بيصير reduction في ال
+
+341
+00:24:27,640 --> 00:24:32,180
+size of a nucleusبسلل الكروموزومات الموجودة فيه
+
+342
+00:24:32,180 --> 00:24:35,720
+إنها more condensed والمسؤول عن الـ more condensed
+
+343
+00:24:35,720 --> 00:24:40,200
+هذه أو الـ condensation العالية هو استبدال بروتين
+
+344
+00:24:40,200 --> 00:24:44,160
+يسمى الهيستون ببروتين يسمى البروتامين يعني في
+
+345
+00:24:44,160 --> 00:24:48,980
+الأصل الهيستون هو البروتين المهيمن الموجود داخل
+
+346
+00:24:48,980 --> 00:24:52,180
+الـ spermatin خلال تطور الـ spermatin للوصول إلى
+
+347
+00:24:52,180 --> 00:24:56,140
+الـ spermatozoa يتم استبدال كل الهيستون ببروتين
+
+348
+00:24:56,140 --> 00:24:59,240
+أخر اسمه البروتامين وهو عبارة عن البروتامين one
+
+349
+00:24:59,650 --> 00:25:03,650
+بروتمين 2 و لازم يكون ال ratio ما بين بروتمين 1 و
+
+350
+00:25:03,650 --> 00:25:07,330
+بروتمين 2 في ال mature sperm واحد تواحد يعني لو
+
+351
+00:25:07,330 --> 00:25:12,890
+عندي 50% بروتمين 1 لازم يكون عندي 50% بروتمين 2
+
+352
+00:25:12,890 --> 00:25:16,190
+هذا المقصود بال ratio one to one هذا أول ال change
+
+353
+00:25:16,190 --> 00:25:21,090
+بيصير ال change التاني ال cytoplasm بيبدأ ينحصر و
+
+354
+00:25:21,090 --> 00:25:25,850
+يبتعد عن النواء إلى حد ما by condensation of
+
+355
+00:25:25,850 --> 00:25:29,860
+geology apparatus at theapilical end of the
+
+356
+00:25:29,860 --> 00:25:33,180
+nucleus ultimately giving rise to the acrosome
+
+357
+00:25:33,180 --> 00:25:37,540
+بيبدأ الـ cytoplasm ينحصر علشان يكون الـ acrosome
+
+358
+00:25:37,540 --> 00:25:41,060
+و الـ acrosome هي عبارة عن منطقة موجودة في طرف الـ
+
+359
+00:25:41,060 --> 00:25:45,060
+head الخاص بالـ sperm مسئول عن عملية ال
+
+360
+00:25:45,060 --> 00:25:47,260
+fertilization لأنه يحتوى على نسبة عالية من
+
+361
+00:25:47,260 --> 00:25:52,040
+الإنزيمات التي تستطيع أن تخترق الوعدة ال acrosome
+
+362
+00:25:52,040 --> 00:25:56,560
+هو عبارة عن packageبيحتوى على إنزيمات إنزايم في
+
+363
+00:25:56,560 --> 00:25:58,420
+الـ structure that play a very important role
+
+364
+00:25:58,420 --> 00:26:01,960
+during fertilization process at the other hand, a
+
+365
+00:26:01,960 --> 00:26:06,200
+nucleus arised flagella أو flagellum growing out
+
+366
+00:26:06,200 --> 00:26:10,160
+on the centriole region في الجهة المعاكسة من
+
+367
+00:26:10,160 --> 00:26:14,640
+النواء، بلاجة في زائدة بدأت تظهر بشكل كبير ويتم
+
+368
+00:26:14,640 --> 00:26:18,140
+استطالتها، بنسميها flagella وهي المسؤولة عن
+
+369
+00:26:18,140 --> 00:26:22,060
+الحركة، الصوتالميتاكندريا الموجودة في الـ mid
+
+370
+00:26:22,060 --> 00:26:25,680
+piece هو موجودة على طول الـ flagella عشان كده في
+
+371
+00:26:25,680 --> 00:26:29,860
+البداية حكينا إن ال sperm يعتبر أصغر الخلايا
+
+372
+00:26:29,860 --> 00:26:33,340
+الموجودة في ال human لا يحتوي على single متاكندريا
+
+373
+00:26:33,340 --> 00:26:37,320
+فقط، لأ يحتوي على عدد كبير من الميتاكندريا القصيد
+
+374
+00:26:37,320 --> 00:26:42,060
+إلى 70 متاكندريا على الأقل ولكن ما نراه هو عبارة
+
+375
+00:26:42,060 --> 00:26:44,000
+عن الميتاكندريا الموجودة في ال mid piece، في
+
+376
+00:26:44,000 --> 00:26:48,180
+القطعة الأوسطة، ولكن في أنديكمية كبيرة جداً وعداد
+
+377
+00:26:48,180 --> 00:26:51,320
+كبير جداً من الميتاكندريا موجودة على طول الـ tail
+
+378
+00:26:51,320 --> 00:26:55,000
+الخاص بالـ sperm وإلا من وين كمية الحركة اللي
+
+379
+00:26:55,000 --> 00:27:00,920
+هيكون موجودة في ال sperm وليكل sperm يتمتع فيها ال
+
+380
+00:27:00,920 --> 00:27:05,600
+spermogenesis is a process and duration around 60
+
+381
+00:27:05,600 --> 00:27:09,740
+-40 to 70-40 days يعني المرحلة أو الوقت اللي
+
+382
+00:27:09,740 --> 00:27:14,170
+بيستهلكوا تكوين ال spermتحت مصطلح spermatogenesis
+
+383
+00:27:14,170 --> 00:27:22,330
+بياخدله من 64 يوم ل 74 يوم يعني تقريبا شهر .. عفوا
+
+384
+00:27:22,330 --> 00:27:26,410
+شهرين شهرين و نص علشان يتكون ال spermatocyte يعني
+
+385
+00:27:26,410 --> 00:27:31,070
+ال duration تبع ال spermatogenesis من 64 ل 74 يوم
+
+386
+00:27:31,070 --> 00:27:35,610
+طبعا بعد ال 74 يوم ال new cycle هتتكون من أول و
+
+387
+00:27:35,610 --> 00:27:42,430
+جديد بعد 16 يوم يعني خليني أقولصح التعبير وكان
+
+388
+00:27:42,430 --> 00:27:47,330
+التعبير تقييم ان كل 16 يوم لازم يصير عندى cycle كل
+
+389
+00:27:47,330 --> 00:27:51,970
+16 يوم لازم يصير عندى cycle يعني في الشهر في two
+
+390
+00:27:51,970 --> 00:27:58,070
+cycle كل cycle بتطلع minimum 130 مليون يعني عندى
+
+391
+00:27:58,070 --> 00:28:03,730
+ما يقارب 260 مليون sperm في اليوم بيطلع اه عفوا
+
+392
+00:28:03,730 --> 00:28:10,130
+اذا كان عندى عفوا في اليوم 130 sperm اضربفي 130 في
+
+393
+00:28:10,130 --> 00:28:14,130
+30 يوم علشان تشوف أكم الـ sperm ممكن يطلع خلال
+
+394
+00:28:14,130 --> 00:28:18,510
+الشهر و ممكن ينطلع خلال الشهر صورة بتوضح الكلام
+
+395
+00:28:18,510 --> 00:28:21,890
+اللي أنا حكيته من spermatogonium تدخل في المقسام
+
+396
+00:28:21,890 --> 00:28:24,730
+الميتوزي تحصل فيه ال DNA replication و ال
+
+397
+00:28:24,730 --> 00:28:27,790
+transcription و ال repairing هتعطيني primary
+
+398
+00:28:27,790 --> 00:28:31,530
+oocyte أو after primary spermatocyteالبراميرو
+
+399
+00:28:31,530 --> 00:28:34,650
+سبيرماتوسايت تدخل من قسام الميوز الأول خلال 24 يوم
+
+400
+00:28:34,650 --> 00:28:38,210
+وبتعطيني secondary spermatocyte سكندر سبيرماتوسايت
+
+401
+00:28:38,210 --> 00:28:41,970
+بتدخل من قسام الميتو ميوز الثاني خلال 8 ساعات
+
+402
+00:28:41,970 --> 00:28:45,090
+وبتعطيني spermative ال spermative بتنتقل إلى ال
+
+403
+00:28:45,090 --> 00:28:49,930
+embedded muscle من أجل التخزين و ال maturation هذه
+
+404
+00:28:49,930 --> 00:28:52,790
+العملية كلها فبتعطيني في النهاية sperm أو
+
+405
+00:28:52,790 --> 00:28:58,050
+spermatozoa هذه العملية كلها بتحتاج من 64 إلى 74
+
+406
+00:28:58,050 --> 00:29:04,310
+يوموالcycle تبدأ كل 16 يوم عندى cycle جديد نشوف
+
+407
+00:29:04,310 --> 00:29:08,610
+الفيديو التانى المتعلق فى عملية spermatogenesis و
+
+408
+00:29:08,610 --> 00:29:14,570
+التخلقة sperm
+
+409
+00:29:14,570 --> 00:29:17,710
+develop in the seminiferous tubules of the testes
+
+410
+00:29:17,710 --> 00:29:22,250
+primordial sperm cells called spermatogonia lie
+
+411
+00:29:22,250 --> 00:29:24,810
+dormant in the outer compartment of the tubules
+
+412
+00:29:24,810 --> 00:29:29,360
+from the late fetal period until pubertyفي
+
+413
+00:29:29,360 --> 00:29:31,820
+الحيوانات، الـSpermatogonia تتعامل بمعادلات
+
+414
+00:29:31,820 --> 00:29:35,180
+ميوتكية تجعلها تتعامل بمعادلات ميوتكية تتعامل
+
+415
+00:29:35,180 --> 00:29:35,900
+بمعادلات ميوتكية تتعامل بمعادلات ميوتكية تتعامل
+
+416
+00:29:35,900 --> 00:29:38,720
+بمعادلات ميوتكية تتعامل بمعادلات ميوتكية تتعامل
+
+417
+00:29:38,720 --> 00:29:39,900
+بمعادلات ميوتكية تتعامل بمعادلات ميوتكية تتعامل
+
+418
+00:29:39,900 --> 00:29:41,640
+بمعادلات ميوتكية تتعامل بمعادلات ميوتكية تتعامل
+
+419
+00:29:41,640 --> 00:29:47,280
+بمعادلات ميوتكية تتعامل بمعادلات ميوتكية تتعامل
+
+420
+00:29:47,280 --> 00:29:51,880
+بمعادلات
+
+421
+00:29:51,880 --> 00:29:56,220
+ميوت
+
+422
+00:29:57,980 --> 00:30:02,260
+عادةً إلى أربع مخلوقات مسمى Spermatids تحتوي على
+
+423
+00:30:02,260 --> 00:30:06,960
+نصف جزء من مادة جنية والدته. من خلال عملية تسمى
+
+424
+00:30:06,960 --> 00:30:11,380
+Spermogenesis، تغيير شكل Spermatids إلى مخلوقات
+
+425
+00:30:11,380 --> 00:30:16,380
+مطورة من الجلد. نوكلياس Spermatids يتحرك، ويظهر
+
+426
+00:30:16,380 --> 00:30:21,980
+العقرزوم، ويبدأ تنمو، وكثير من الـCytoplasm يتم
+
+427
+00:30:21,980 --> 00:30:22,280
+حرقه.
+
+428
+00:30:37,990 --> 00:30:45,010
+بعد ما يتم عملية تخليق ال spermatozoa ولكن قبل
+
+429
+00:30:45,010 --> 00:30:47,510
+عملية ال maturation ينتقلوا لمنطقة بسميها
+
+430
+00:30:47,510 --> 00:30:53,470
+Epidermis المسؤول عن ال maturation لل spermatozoa
+
+431
+00:30:53,470 --> 00:30:59,740
+وتحويلها إلى full functional spermهذه عبارة عن
+
+432
+00:30:59,740 --> 00:31:05,760
+عملية spermogenesis بالشكل المبسط المعروف طبعا هذه
+
+433
+00:31:05,760 --> 00:31:09,160
+العملية كلها في عنده هرمون بيأثر عليها سواء كان
+
+434
+00:31:09,160 --> 00:31:12,340
+على الـ Oogenesis هرمونات بتأثر عليها على ال
+
+435
+00:31:12,340 --> 00:31:16,380
+spermogenesis هرمونات بتأثر عليها هنتكلم عن
+
+436
+00:31:16,380 --> 00:31:19,920
+الهرمونات التي تؤثر على الـ Oogenesis و الهرمونات
+
+437
+00:31:19,920 --> 00:31:27,300
+التي تؤثر على ال spermogenesis على حدة نبدأ
+
+438
+00:31:27,300 --> 00:31:32,200
+بمقارنة بسيطة ما بين spermatogenesis و ال
+
+439
+00:31:32,200 --> 00:31:36,960
+oogenesis ال oogenesis طبعا تحبث اسمها عفوا المكان
+
+440
+00:31:36,960 --> 00:31:40,880
+الحدود في ال spermatogenesis في ال male و ال
+
+441
+00:31:40,880 --> 00:31:45,840
+oogenesis في ال female ال formation في اسم ال
+
+442
+00:31:45,840 --> 00:31:48,860
+nervous tupule and of testis في ال ovary ال
+
+443
+00:31:48,860 --> 00:31:53,060
+process production of sperm from spermatogonium
+
+444
+00:31:53,060 --> 00:31:57,760
+ادى production of ovum from ogonia ال production
+
+445
+00:31:58,820 --> 00:32:02,460
+عملية ال production بتكون في ال male مستمرة و
+
+446
+00:32:02,460 --> 00:32:07,940
+بتستغرق ما يقارب 74 يوم it occur after puberty
+
+447
+00:32:07,940 --> 00:32:13,260
+until death مافيش توقف أما في ال female فعملية ال
+
+448
+00:32:13,260 --> 00:32:18,460
+production ما بتكون continuously تستغرق
+
+449
+00:32:18,460 --> 00:32:23,940
+أيام قليلة جدا ما يقارب 28 يوم إذا جمعنا ال
+
+450
+00:32:23,940 --> 00:32:29,050
+menstrual cycle days كلهاتبدأ بعد الـ Puberty و
+
+451
+00:32:29,050 --> 00:32:32,370
+تتوقف عند الـ Menopausal أو الـ Menopausal Stage
+
+452
+00:32:32,370 --> 00:32:35,850
+الـ Stage الخاصة بالـ Spermatogenesis كلها بتصير
+
+453
+00:32:35,850 --> 00:32:39,670
+داخل الـ Testis أما بالنسبة للـ Oogenesis كلها
+
+454
+00:32:39,670 --> 00:32:45,550
+بتصير داخل الـ Ovary باستثناءمنطقة أو باستثناء حدث
+
+455
+00:32:45,550 --> 00:32:53,110
+وحيد له علاقة باستكمال مضوج البويضة وفقدانها نصف
+
+456
+00:32:53,110 --> 00:32:55,550
+عدد الكرموزومات أو هذا لا تحدث إلا بعد ال
+
+457
+00:32:55,550 --> 00:32:58,810
+fertilization اللذي يحدث في الفلوجيات أما
+
+458
+00:32:58,810 --> 00:33:02,390
+releasing sperm are released from the testes as
+
+459
+00:33:02,390 --> 00:33:06,130
+sperm ال oocyte releasing from ovary after
+
+460
+00:33:06,130 --> 00:33:10,160
+maturation the growth phasetoo short بالنسبة لل
+
+461
+00:33:10,160 --> 00:33:15,440
+spermatogenesis أما بالنسبة لل oogenesis
+
+462
+00:33:15,440 --> 00:33:18,700
+prolongate تاخد فترة زمنية طويلة عشان يصير فيها
+
+463
+00:33:18,700 --> 00:33:25,300
+نمو أما بالنسبة لل food reserve ال sperm ما بحتاج
+
+464
+00:33:25,300 --> 00:33:29,240
+مخزون من الطعام بشكل كبير جدا لأنه هيقدر وظيفة
+
+465
+00:33:29,240 --> 00:33:33,000
+خاصة فيه ينتهي أما ال ova مهم جدا أن يكون فيها
+
+466
+00:33:33,000 --> 00:33:36,540
+عنده مخزون كبير جدا من ال food لأن ال ova هي التي
+
+467
+00:33:36,540 --> 00:33:42,310
+ستتحول إلى embryoبعد عملية التخصام طيب، شو هي
+
+468
+00:33:42,310 --> 00:33:45,230
+الهرمونات؟ هذه مقارنة بسيطة ما بين الـ Oogenesis
+
+469
+00:33:45,230 --> 00:33:48,630
+والـ Spermatogenesis طيب، شو هي الهرمونات التي
+
+470
+00:33:48,630 --> 00:33:54,110
+تعمل على الـ reproductive system اندل female خلال
+
+471
+00:33:54,110 --> 00:33:59,030
+الـ menstrual cycle؟ طبعا، بنقول إن كل ال tissue
+
+472
+00:33:59,030 --> 00:34:02,630
+الخاصة بالـ reproductive system اندل female تتأثر
+
+473
+00:34:02,630 --> 00:34:06,490
+بهرمونات معينة تسمى الـ reproductive hormone ومن
+
+474
+00:34:06,490 --> 00:34:11,270
+أشهرهذه الـ reproductive hormone الـ FSH الـ LH
+
+475
+00:34:11,270 --> 00:34:15,430
+الاستروجين والبروجسترون هذه أشهر أربع هرمونات على
+
+476
+00:34:15,430 --> 00:34:18,530
+الإطلاق فعلى سبيل المثال in response to the
+
+477
+00:34:18,530 --> 00:34:21,890
+hormonal environment of the body this tissue
+
+478
+00:34:21,890 --> 00:34:25,030
+undergoes cyclic modification that improve the
+
+479
+00:34:25,030 --> 00:34:28,790
+chance of successful production طبعا الاتجاه الخاص
+
+480
+00:34:28,790 --> 00:34:32,320
+في ال reproductive system تحت أثير هرموناتمعينة
+
+481
+00:34:32,320 --> 00:34:37,440
+موجودة في جسم السيدات هتبدأ هذه الانسجاة تستقبل
+
+482
+00:34:37,440 --> 00:34:40,940
+هذه الهرمونات فيحدث عليها modification بيخليها
+
+483
+00:34:40,940 --> 00:34:46,880
+أكثر قدرة واستجابة لعملية ال reproduction تنجح
+
+484
+00:34:46,880 --> 00:34:49,960
+عملية ال reproduction في حالة استجابة الانسجاة
+
+485
+00:34:49,960 --> 00:34:54,900
+للهرمونات طبعا ال response to both FSH and LH for
+
+486
+00:34:54,900 --> 00:34:58,460
+example this hormone secreted from anterior lobe
+
+487
+00:34:58,460 --> 00:35:02,030
+of pituitary glandالفص الأمامي للبتيوتري بيبرستو
+
+488
+00:35:02,030 --> 00:35:05,510
+هرمون Follicular Stimulating Hormone بسمي FSH
+
+489
+00:35:05,510 --> 00:35:09,710
+Glutalizing Hormone بسمي LH طبعا هدول الهرمون
+
+490
+00:35:09,710 --> 00:35:14,650
+يفرزوا secreted by pituitary just before and
+
+491
+00:35:14,650 --> 00:35:18,670
+during menstrual period يعني قبل الدورة أو خلال
+
+492
+00:35:18,670 --> 00:35:22,410
+الدورة طبعا إلهم وظيفة معينة أو أهمية معينة
+
+493
+00:35:22,410 --> 00:35:25,770
+وظيفتهم عند ال male يختلف عن ال female إحنا بنحكي
+
+494
+00:35:25,770 --> 00:35:28,680
+عن ال female في هذا اللحظةAsset of secondary
+
+495
+00:35:28,680 --> 00:35:32,440
+ovarian follicle beginning to mature and secreted
+
+496
+00:35:32,440 --> 00:35:38,800
+estradiol 170-beta-estradiol or estrogen يعني
+
+497
+00:35:38,800 --> 00:35:43,420
+بمجرد ما يتم إفراز الـFSH والـLH هرمون الـovarian
+
+498
+00:35:43,420 --> 00:35:47,300
+follicle تستجيب إلى هذه الهرمونات وتبدأ بإفراز
+
+499
+00:35:47,300 --> 00:35:51,720
+هرمون آخر بنسميه الـE2 هرمون أو الـestrogen
+
+500
+00:35:51,720 --> 00:35:55,000
+hormone وهو الهرمون المسئول عن الـovarian hormone
+
+501
+00:35:55,880 --> 00:36:01,260
+في عين اتنين ovarian hormone الـ E2 و البروجسترول
+
+502
+00:36:01,260 --> 00:36:05,100
+طيب، by ovulation, all of this follicle except one
+
+503
+00:36:05,100 --> 00:36:08,500
+have undergo atresia و هذا الكلام حكيناه عند لحظة
+
+504
+00:36:08,500 --> 00:36:11,320
+ال ovulation فقط اللي بيصيرها ovulation الفويدة
+
+505
+00:36:11,320 --> 00:36:17,560
+المتطورة الناضجة اللتي وصلت إلى 18 ل 36 مليمتر أس
+
+506
+00:36:17,560 --> 00:36:21,360
+ديامتر فممكن تكون واحدة، ممكن تكون تلتين، ممكن
+
+507
+00:36:21,360 --> 00:36:26,530
+تكون تلاتة، okay في الوضع الطبيعيو 1،2،3 في الوضع
+
+508
+00:36:26,530 --> 00:36:31,050
+الطبيعي مافيش أي مشكلة طيب شو هي ال phases الخاصة
+
+509
+00:36:31,050 --> 00:36:34,290
+بال menstrual cycle؟ هل الدورة الشهرية عند السيدة
+
+510
+00:36:34,290 --> 00:36:38,150
+إلها أطوار معينة؟ أكيد إلها أطوار معينة في الوضع
+
+511
+00:36:38,150 --> 00:36:41,210
+الطبيعي ال menstrual cycle بتبدأ من أول يوم
+
+512
+00:36:41,210 --> 00:36:45,490
+bleedingفبنقول إن أول يوم bleeding صار مثلا خمسة
+
+513
+00:36:45,490 --> 00:36:49,870
+ديسمبر إذا خمسة ديسمبر هو أول يوم في الدورة أكذا
+
+514
+00:36:49,870 --> 00:36:55,230
+تحسب .. أكذا تحسب ولا تحسب من لحظة انقطاع الطمس أو
+
+515
+00:36:55,230 --> 00:36:59,990
+لحظة توقف ال bleeding لأ الدورة بالشكل الصحيح تحسب
+
+516
+00:36:59,990 --> 00:37:03,550
+من أول يوم bleeding فبسميها .. هي عبارة عن ال
+
+517
+00:37:03,550 --> 00:37:07,490
+first time إذا صار في bleeding عندك تسعة الشهر
+
+518
+00:37:07,490 --> 00:37:10,790
+معناها تسعة الشهر هو أول يوم في الدورةلأنه ليش أنا
+
+519
+00:37:10,790 --> 00:37:15,270
+معنى بشكل كبير جدا أعرف أول يوم في الدورة لأنه
+
+520
+00:37:15,270 --> 00:37:19,730
+بناء عليه الطبيب بيحسب متى يوم التبويض أو السيدة
+
+521
+00:37:19,730 --> 00:37:23,110
+بتقدر من خلالها تعرف متى هي أيام التبويض اللي
+
+522
+00:37:23,110 --> 00:37:27,670
+بتكون في الغالب يوم 13 و14 إذا كانت الدورة منتظمة
+
+523
+00:37:27,670 --> 00:37:31,310
+عند السيدة في الوضع الطبيعي معظم السيدات بتاخد
+
+524
+00:37:31,310 --> 00:37:36,110
+الدورة عندهم من 3 ل7 أيام بعض الأحيان 8 أيام ال
+
+525
+00:37:36,110 --> 00:37:40,060
+averageخمس أيام ال average خمس أيام في بعض السيدات
+
+526
+00:37:40,060 --> 00:37:44,360
+بتمنع عشر أيام و اتناشر يوم ادحالات خاصة نوادر
+
+527
+00:37:44,360 --> 00:37:48,100
+ولكن in general تلاتة لسبع أيام ال syringe ال
+
+528
+00:37:48,100 --> 00:37:52,820
+average خمس أيام اول طور من اطوار الدورة الشهرية
+
+529
+00:37:52,820 --> 00:37:56,120
+من ال stroll cycle من الطور بنسميه minicetral
+
+530
+00:37:56,120 --> 00:38:01,690
+phase وهو عبارةعن الفترة الزمنية من واحد لخمس أيام
+
+531
+00:38:01,690 --> 00:38:05,350
+اللي سميتها ال average chemistry في هذا الطور
+
+532
+00:38:05,350 --> 00:38:08,230
+مستحيل يصير fertilization لأنه أصلا مافيش فوائدة
+
+533
+00:38:08,230 --> 00:38:12,130
+level of hormone like estrogen and progesterone
+
+534
+00:38:12,130 --> 00:38:16,050
+will be drop or reduction or decrease و ال corpus
+
+535
+00:38:16,050 --> 00:38:19,790
+luteum سير دي V-degeneration الطور اللي بنسميه من
+
+536
+00:38:19,790 --> 00:38:24,530
+واحد لخمسة .. من أول خمس أيام من الدورة الشهرية هو
+
+537
+00:38:24,530 --> 00:38:29,200
+.. هو بيسميهpower and intensity الـ bleeding time
+
+538
+00:38:29,200 --> 00:38:32,540
+أو ال bleeding phase طبعا طالما في عنده bleeding
+
+539
+00:38:32,540 --> 00:38:37,040
+phase معناه كل بطانة الرحم سوف يحدث تدمير لها
+
+540
+00:38:37,040 --> 00:38:41,600
+وتنزل على هي blood هذا بياخد من يوم لخمس أيام as
+
+541
+00:38:41,600 --> 00:38:46,860
+average طبعا مافي fertilization لأنه مافيش بوادة و
+
+542
+00:38:46,860 --> 00:38:49,180
+ال progesterone hormone و ال estrogen hormone
+
+543
+00:38:49,180 --> 00:38:53,340
+بيصير فيهم reductionوالكوربس اليوتام الجسم الأصفر
+
+544
+00:38:53,340 --> 00:38:56,260
+المسؤول عن تغذية الجنين بصيله degeneration لأنه
+
+545
+00:38:56,260 --> 00:39:00,800
+أصلا ليس هناك جنين فيه دورة هذا يسبب في الانتقال
+
+546
+00:39:00,800 --> 00:39:05,560
+من الاندو ماتيريام يتسبب في تخلص من الدم يحمي
+
+547
+00:39:05,560 --> 00:39:10,800
+تشوات محطمة طبعا هذا الدم هو عبارة عن بطانة الرحم
+
+548
+00:39:10,800 --> 00:39:16,220
+اللي اتكسرت لأنه ما لها فايدة أو function في الوقت
+
+549
+00:39:16,220 --> 00:39:20,170
+الحاليفبتنزل مع ال bleed .. مع ال blood this
+
+550
+00:39:20,170 --> 00:39:24,070
+follow of blood is called menstruation أو
+
+551
+00:39:24,070 --> 00:39:27,510
+menstruation .. menstruation هذه ال blooding اللي
+
+552
+00:39:27,510 --> 00:39:31,150
+بنزل أو ال blood اللي بنزل بنسمي menstruation يعني
+
+553
+00:39:31,150 --> 00:39:35,430
+الدورة طبعا الدورة تختلف حدثها في القلم من سيدة
+
+554
+00:39:35,430 --> 00:39:40,310
+إلى سيدة بعضهم بشعر بقلم حاد بعضهم بشعر بقلم طفيل
+
+555
+00:39:40,960 --> 00:39:45,300
+طبعا حتى في مراحل عمر مختلفة ال symptoms تختلف in
+
+556
+00:39:45,300 --> 00:39:49,120
+general ال symptoms بيصير عندي cramping تقلصات في
+
+557
+00:39:49,120 --> 00:39:52,960
+عضلات المعدة و الحوض بيصير عندي انتفاخات بيصير
+
+558
+00:39:52,960 --> 00:39:57,220
+عندي mood fluctuation تقلق مزاج هادية عصبية عصبية
+
+559
+00:39:57,220 --> 00:40:03,260
+هادية مستفزة هكذا بيصير عندي غضب بشكل مستمر أو على
+
+560
+00:40:03,260 --> 00:40:09,440
+فترات صداع إعياء و تعببالاضافة إلى ألام في أسفل
+
+561
+00:40:09,440 --> 00:40:13,160
+الظهر، ألام في أسفل الظهر هذي ال general symptoms
+
+562
+00:40:13,160 --> 00:40:16,200
+اللي بتظهر عند السيدات في مرحلة ال menstrual cycle
+
+563
+00:40:16,200 --> 00:40:20,720
+وبالشكل الأساسي في أول خمس أيام من الدورة اللي
+
+564
+00:40:20,720 --> 00:40:26,680
+سمناها menstrual phaseالثورة التانية اللى بنسميه
+
+565
+00:40:26,680 --> 00:40:30,420
+post من الستروليه وبياخد من اليوم الستة حتى يوم
+
+566
+00:40:30,420 --> 00:40:33,520
+تلتاشر وبعضهم بيقول يوم اربعتاشر يعني بياخد ستة
+
+567
+00:40:33,520 --> 00:40:36,280
+وسبعة و تمانية و تسعة و عشر و واحدة عشر و اتناشر و
+
+568
+00:40:36,280 --> 00:40:40,620
+تلتاشر واربعتاشر يعني ما يقارب تسع أيام خلال هذه
+
+569
+00:40:40,620 --> 00:40:44,540
+المرحلة تبدأ ال primary follicle بالdevelopment
+
+570
+00:40:44,540 --> 00:40:47,320
+والgrowth عشان تصل إلى ال mature stage اللى
+
+571
+00:40:47,320 --> 00:40:51,400
+بنسميها graphian follicle حوايسة ال graph graphian
+
+572
+00:40:51,400 --> 00:40:55,600
+follicleهذه الـ Graphian Follicle أول ما تنمو و
+
+573
+00:40:55,600 --> 00:41:01,120
+تنضج و تظهر بتبدأ تنمي و تهيج الـ Endomaterium
+
+574
+00:41:01,120 --> 00:41:06,000
+بطاقة الرحم ليصيرها regeneration إعادة تصنيع لأن
+
+575
+00:41:06,000 --> 00:41:10,200
+بدون بطاقة الرحم و بدون الـ Endomaterium مافيه
+
+576
+00:41:10,200 --> 00:41:14,620
+implementation إذا حدث عملية تخصيب للبويضة المقصرة
+
+577
+00:41:14,620 --> 00:41:20,940
+إذن تتطور الـ Graphian Follicle تعطيني حواصلات
+
+578
+00:41:20,940 --> 00:41:26,890
+Graphاللي بتساعد الـ Endometrium على النضوج تساعد
+
+579
+00:41:26,890 --> 00:41:30,350
+الـ Endometrium على الـ Regeneration This change
+
+580
+00:41:30,350 --> 00:41:34,110
+in the ovary and the uterus are induced by the
+
+581
+00:41:34,110 --> 00:41:36,770
+change of the level of pituitary hormone and
+
+582
+00:41:36,770 --> 00:41:40,370
+ovarian hormone شو اللي بيحفظ وجود الـ Graafian
+
+583
+00:41:40,370 --> 00:41:43,810
+follicle maturation وجود تغير في مستوى هرمونة الـ
+
+584
+00:41:43,810 --> 00:41:47,250
+pituitary gland زي الـ FH و LH و وجود تغير في
+
+585
+00:41:47,250 --> 00:41:51,870
+مستوى هرمون الـ ovarian hormone زي الـ E2طبعا
+
+586
+00:41:51,870 --> 00:41:55,790
+الجونادوتروبيين الـ FSH و الـ LH بزيد بشكل تدريجي
+
+587
+00:41:55,790 --> 00:41:59,110
+في هذا الـ phase و ببدأ يعمل stimulation للفوليكل
+
+588
+00:41:59,110 --> 00:42:03,390
+عشان تتطور الفوليكل اللي انتطورت تبدأ في إفراز
+
+589
+00:42:03,390 --> 00:42:07,910
+هرمون بنسميه الـ estrogen اللي بدعم نمو الفوليكل
+
+590
+00:42:07,910 --> 00:42:13,050
+both FSH and LH will be arrived to the high peak
+
+591
+00:42:13,050 --> 00:42:17,090
+في اليوم 14 في اليوم 14 أو في متصف الدورة وهي
+
+592
+00:42:17,090 --> 00:42:21,330
+اليوم 14الـ LH والـ FSH لازم يصلوا للـ High Peak
+
+593
+00:42:21,330 --> 00:42:25,810
+أهمهم الـ FSH في هذا المرحلة لإن هو اللي بده يعمل
+
+594
+00:42:25,810 --> 00:42:29,910
+لـ full maturation للفوايضة طب الـ LH إله شغل في
+
+595
+00:42:29,910 --> 00:42:34,470
+phase أخر اسمه ovulation أو ovulatory phase طبعا
+
+596
+00:42:34,470 --> 00:42:37,830
+ال ovulatory phase هو طور التبويض اللي بيحدث في
+
+597
+00:42:37,830 --> 00:42:43,550
+اليوم 13 أو اليوم 14 إذا كانت الدورة ثابتة منطلبة
+
+598
+00:42:43,550 --> 00:42:48,650
+طبعا خلال هذه ال phaseالـ Estrogen level بيرتفع
+
+599
+00:42:48,650 --> 00:42:54,510
+بشكل كبير جدا علشان يعطيني دلالة إن والله الفوليكل
+
+600
+00:42:54,510 --> 00:42:59,290
+نضجت ونمت بالشكل المطلوب نضجت ونمت بالشكل المطلوب
+
+601
+00:42:59,290 --> 00:43:02,750
+مباشرة بتبدأ الـ anterior pituitary gland بإفراز
+
+602
+00:43:02,750 --> 00:43:07,010
+هرمون مهم جدا اسمه الـ Lutilizing hormone الـ LH
+
+603
+00:43:07,010 --> 00:43:12,310
+الـ LH هو Lutilizing hormone بمجرد إفرازه يؤثر على
+
+604
+00:43:12,310 --> 00:43:15,110
+الـ Graafian follicle أو الـ Oocyte follicle
+
+605
+00:43:15,370 --> 00:43:20,010
+وبيعملها عملية rapture فبتطلع البويضة الناضجة تحت
+
+606
+00:43:20,010 --> 00:43:25,210
+مصطلح ovulation تحت مصطلح ovulation وهو عبارة عن
+
+607
+00:43:25,210 --> 00:43:29,470
+عملية التبويض علشان كده في اليوم 13 واليوم 14 لو
+
+608
+00:43:29,470 --> 00:43:33,970
+أنا قصت مستوى هرمون الـH هلاجيه أعلى ما يمكن نسميه
+
+609
+00:43:33,970 --> 00:43:39,610
+ال H wave or surge ال H wave يعني موجة هي أعلى
+
+610
+00:43:39,610 --> 00:43:43,550
+موجة ما بتظهر إلا في الوقت هذا بالذات طبعا ال H
+
+611
+00:43:43,550 --> 00:43:47,400
+waveيؤد إلى عملية الـ ovulation من خلال عمل
+
+612
+00:43:47,400 --> 00:43:51,760
+Rapture لـ Graphian Follicle و البوايضة تطلع طب
+
+613
+00:43:51,760 --> 00:43:53,700
+بعد ما طلعت البوايضة من Graphian Follicle ايش
+
+614
+00:43:53,700 --> 00:43:58,200
+بيصير في Graphian Follicle؟ حواصلات Graphian أو
+
+615
+00:43:58,200 --> 00:44:03,040
+Grab Follicle بيسموها او Graphian تتحول مباشرة إلى
+
+616
+00:44:03,040 --> 00:44:07,580
+جسم بنسميه الجسم الأصفر أو Corpus Luteum الذي يلعب
+
+617
+00:44:07,580 --> 00:44:12,720
+دورة كبيرة ومهمة في بداية الحمل من خلالمن خلال
+
+618
+00:44:12,720 --> 00:44:16,580
+إعطاء هرمون مهم يسمى هرمون لـ Progesterone طبعا
+
+619
+00:44:16,580 --> 00:44:22,740
+الـ ovulatory phase usually lasted 60 to 32 hours
+
+620
+00:44:22,740 --> 00:44:29,220
+يعني بياخده ما بين 16 ساعة ل 32 ساعة في النهاية
+
+621
+00:44:29,220 --> 00:44:33,940
+عندما يتم خروج البويضة حوالي 10 إلى 12 ساعة بعد
+
+622
+00:44:33,940 --> 00:44:40,400
+عملية بتصير بعد إفراز الـ high peak للالتشو عندما
+
+623
+00:44:40,400 --> 00:44:45,020
+تم إفراز القلعب بالكمية كبيرة جدا و أعطاني peak أو
+
+624
+00:44:45,020 --> 00:44:50,820
+wave عد 10 إلى 12 ساعة هي المرحلة اللي ممكن يحدث
+
+625
+00:44:50,820 --> 00:44:56,720
+فيها عملية ال ovulation سنتوقف
+
+626
+00:44:56,720 --> 00:45:00,880
+عند هذا الحد في هذه المحاضرة على أمل أن نستكمل في
+
+627
+00:45:00,880 --> 00:45:03,680
+المحاضرة القادمة ان شاء الله
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/4jXfLSZzJwA_raw.json b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/4jXfLSZzJwA_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..8f4190727a2a0d5786707b4a0037e3228d951045
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/4jXfLSZzJwA_raw.json
@@ -0,0 +1 @@
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{"start": 367.36, "end": 367.8, "word": " ال", "probability": 0.6982421875}, {"start": 367.8, "end": 368.22, "word": " oocyte", "probability": 0.93408203125}, {"start": 368.22, "end": 368.56, "word": " بتروح", "probability": 0.90234375}, {"start": 368.56, "end": 369.1, "word": " أتريجيا", "probability": 0.9775390625}, {"start": 369.1, "end": 369.84, "word": " ال", "probability": 0.430419921875}, {"start": 369.84, "end": 370.06, "word": " stage", "probability": 0.355224609375}, {"start": 370.06, "end": 370.5, "word": " التاني", "probability": 0.8479817708333334}, {"start": 370.5, "end": 370.66, "word": " أو", "probability": 0.81396484375}, {"start": 370.66, "end": 371.06, "word": " المرحلة", "probability": 0.9874267578125}, {"start": 371.06, "end": 371.4, "word": " التانية", "probability": 0.9765625}, {"start": 371.4, "end": 371.52, "word": " اللي", "probability": 0.8642578125}, {"start": 371.52, "end": 371.7, "word": " بيصير", "probability": 0.771240234375}, {"start": 371.7, "end": 371.86, "word": " فيها", "probability": 0.974609375}, {"start": 371.86, "end": 372.36, "word": " أتريجيا", "probability": 0.9833984375}], "temperature": 1.0}, {"id": 15, "seek": 39032, "start": 372.72, "end": 390.32, "text": "في حاجة نسميها الـ Formation of Primary Follicle إذا تلت مراحل أساسية يتم فيها 99% من الأتراجيا الخاصة بالـ Follicle أو الـ Oocyte المرحلة الأولى خلال الـ shifting من الميوزي للميوزي المرحلة التانية من ال progression الـthroprophase I", "tokens": [41185, 11331, 26108, 3660, 8717, 38251, 1829, 11296, 2423, 39184, 10126, 399, 295, 42576, 479, 1833, 3520, 11933, 15730, 6055, 1211, 2655, 3714, 23557, 5016, 1211, 5551, 3794, 32277, 10632, 7251, 39237, 8978, 11296, 11803, 4, 9154, 16247, 2655, 2288, 26108, 25528, 33962, 33546, 3660, 20666, 39184, 479, 1833, 3520, 34051, 2423, 39184, 422, 31078, 975, 9673, 2288, 5016, 37977, 16247, 12610, 7578, 16490, 1211, 6027, 2423, 39184, 17573, 9154, 9673, 1829, 2407, 11622, 1829, 5296, 19528, 1829, 2407, 11622, 1829, 9673, 2288, 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" تلت", "probability": 0.7955729166666666}, {"start": 376.34, "end": 376.78, "word": " مراحل", "probability": 0.9617919921875}, {"start": 376.78, "end": 377.36, "word": " أساسية", "probability": 0.97900390625}, {"start": 377.36, "end": 378.24, "word": " يتم", "probability": 0.80810546875}, {"start": 378.24, "end": 378.68, "word": " فيها", "probability": 0.988525390625}, {"start": 378.68, "end": 379.7, "word": " 99", "probability": 0.87060546875}, {"start": 379.7, "end": 380.06, "word": "%", "probability": 0.96826171875}, {"start": 380.06, "end": 380.3, "word": " من", "probability": 0.98046875}, {"start": 380.3, "end": 380.98, "word": " الأتراجيا", "probability": 0.82294921875}, {"start": 380.98, "end": 381.66, "word": " الخاصة", "probability": 0.98388671875}, {"start": 381.66, "end": 381.86, "word": " بالـ", "probability": 0.7222900390625}, {"start": 381.86, "end": 382.26, "word": " Follicle", "probability": 0.8082682291666666}, {"start": 382.26, "end": 382.52, "word": " أو", "probability": 0.943359375}, {"start": 382.52, "end": 382.66, "word": " الـ", "probability": 0.851318359375}, {"start": 382.66, "end": 383.54, "word": " Oocyte", "probability": 0.9112955729166666}, {"start": 383.54, "end": 384.04, "word": " المرحلة", "probability": 0.90771484375}, {"start": 384.04, "end": 384.4, "word": " الأولى", "probability": 0.9954427083333334}, {"start": 384.4, "end": 384.76, "word": " خلال", "probability": 0.9747721354166666}, {"start": 384.76, "end": 384.88, "word": " الـ", "probability": 0.81005859375}, {"start": 384.88, "end": 385.12, "word": " shifting", "probability": 0.5166015625}, {"start": 385.12, "end": 385.34, "word": " من", "probability": 0.98681640625}, {"start": 385.34, "end": 386.02, "word": " الميوزي", "probability": 0.742236328125}, {"start": 386.02, "end": 386.8, "word": " للميوزي", "probability": 0.8931477864583334}, {"start": 386.8, "end": 387.62, "word": " المرحلة", "probability": 0.9566650390625}, {"start": 387.62, "end": 387.96, "word": " التانية", "probability": 0.9607747395833334}, {"start": 387.96, "end": 388.12, "word": " من", "probability": 0.96240234375}, {"start": 388.12, "end": 388.26, "word": " ال", "probability": 0.76513671875}, {"start": 388.26, "end": 388.82, "word": " progression", "probability": 0.830078125}, {"start": 388.82, "end": 390.1, "word": " الـthroprophase", "probability": 0.44736328125}, {"start": 390.1, "end": 390.32, "word": " I", "probability": 0.654296875}], "temperature": 1.0}, {"id": 16, "seek": 41595, "start": 390.55, "end": 415.95, "text": "و المرحلة التالتة من خلال Formation of Primary Follicle هل بيأثر الاببتوسز على مناطق معينة وجزيئات معينة وعضيات معينة داخل الخلية أم يؤثر على الخلية بشكل عام الاببتوسز وجدوا أنه during Prophase I is likely related to defect DNA crossing repair نحن نعرف أن هناك شيء يسمى Crossing Over", "tokens": [2407, 9673, 2288, 5016, 37977, 16712, 6027, 2655, 3660, 9154, 16490, 1211, 6027, 10126, 399, 295, 42576, 479, 1833, 3520, 8032, 1211, 4724, 1829, 10721, 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"probability": 0.6591796875}, {"start": 412.49, "end": 413.15, "word": " repair", "probability": 0.94677734375}, {"start": 413.15, "end": 414.09, "word": " نحن", "probability": 0.6761067708333334}, {"start": 414.09, "end": 414.47, "word": " نعرف", "probability": 0.890625}, {"start": 414.47, "end": 414.69, "word": " أن", "probability": 0.8134765625}, {"start": 414.69, "end": 414.83, "word": " هناك", "probability": 0.7144775390625}, {"start": 414.83, "end": 414.97, "word": " شيء", "probability": 0.646484375}, {"start": 414.97, "end": 415.15, "word": " يسمى", "probability": 0.8748372395833334}, {"start": 415.15, "end": 415.51, "word": " Crossing", "probability": 0.72705078125}, {"start": 415.51, "end": 415.95, "word": " Over", "probability": 0.55859375}], "temperature": 1.0}, {"id": 17, "seek": 43464, "start": 416.34, "end": 434.64, "text": "ببين الـ two-sister chromatid أنه في قطع بتنتقل من كروموزوم إلى كروموزوم آخر بشرط أنه نفس الكروموزوم، واحد مع واحد، خمسة مع خمسة، لبعض الأحيان بيصير هندي up normal, crossing over، قطعة من اتنين بتروح لقطع من الخمسة، مثلا، ففي repair system بيرجعه لوضعه الأصلي", "tokens": [3555, 3555, 9957, 2423, 39184, 732, 12, 82, 1964, 16209, 267, 327, 14739, 3224, 8978, 12174, 9566, 3615, 39894, 29399, 4587, 1211, 9154, 9122, 2288, 20498, 2407, 11622, 20498, 30731, 9122, 2288, 20498, 2407, 11622, 20498, 19753, 34740, 4724, 8592, 2288, 9566, 14739, 3224, 8717, 36178, 33251, 2288, 20498, 2407, 11622, 20498, 12399, 36764, 24401, 20449, 36764, 24401, 12399, 16490, 2304, 3794, 3660, 20449, 16490, 2304, 3794, 3660, 12399, 5296, 3555, 3615, 11242, 16247, 5016, 1829, 7649, 4724, 1829, 9381, 13546, 8032, 1863, 16254, 493, 2710, 11, 14712, 670, 12399, 12174, 9566, 27884, 9154, 1975, 2655, 1863, 9957, 39894, 32887, 5016, 5296, 47432, 3615, 9154, 33962, 2304, 3794, 3660, 12399, 50113, 15040, 12399, 6156, 41185, 10535, 1185, 4724, 13546, 7435, 3615, 3224, 45164, 11242, 3615, 3224, 16247, 9381, 20292], "avg_logprob": -0.21069711974033942, "compression_ratio": 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"word": " خمسة،", "probability": 0.86337890625}, {"start": 425.78, "end": 426.52, "word": " لبعض", "probability": 0.8572998046875}, {"start": 426.52, "end": 426.9, "word": " الأحيان", "probability": 0.9844970703125}, {"start": 426.9, "end": 427.18, "word": " بيصير", "probability": 0.873291015625}, {"start": 427.18, "end": 427.54, "word": " هندي", "probability": 0.6861979166666666}, {"start": 427.54, "end": 428.14, "word": " up", "probability": 0.2247314453125}, {"start": 428.14, "end": 428.54, "word": " normal,", "probability": 0.48779296875}, {"start": 428.7, "end": 428.84, "word": " crossing", "probability": 0.78515625}, {"start": 428.84, "end": 429.32, "word": " over،", "probability": 0.71337890625}, {"start": 429.32, "end": 429.6, "word": " قطعة", "probability": 0.9500325520833334}, {"start": 429.6, "end": 429.72, "word": " من", "probability": 0.99609375}, {"start": 429.72, "end": 430.02, "word": " اتنين", "probability": 0.8214111328125}, {"start": 430.02, "end": 430.34, "word": " 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بنسميه crossing over repair system صار defect لهذا ال system معناه الخلية هذه اللي صار فيها defect أو البوايضة اللي صار فيها defect أو الفولكل اللي صار فيها defect تعتبر abnormal فولكل فبصير لها degradation أو أتراجع whereas that in later stage of oogenesis is often caused", "tokens": [28814, 15730, 20328, 9640, 8978, 18871, 16254, 37893, 28820, 3660, 8978, 2423, 10535, 1185, 4032, 13672, 1829, 44945, 38251, 1829, 3224, 14712, 670, 10535, 1185, 20328, 9640, 16445, 46740, 15730, 2423, 1185, 20449, 8315, 3224, 33962, 1211, 10632, 29538, 13672, 1829, 20328, 9640, 8978, 11296, 16445, 34051, 29739, 14407, 1829, 11242, 3660, 13672, 1829, 20328, 9640, 8978, 11296, 16445, 34051, 27188, 12610, 28820, 13672, 1829, 20328, 9640, 8978, 11296, 16445, 6055, 34268, 26890, 32847, 6156, 12610, 28820, 6156, 3555, 9381, 13546, 5296, 11296, 40519, 34051, 5551, 2655, 2288, 26108, 3615, 9735, 300, 294, 1780, 3233, 295, 277, 8799, 9374, 307, 2049, 7008], "avg_logprob": -0.1961468472642806, 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functional تبع الـ follicular cell من حيث الـ distribution و من حيث ال support في بعض ال substance لازم تكون موجودة فتعمل supporting لـ development و maturation لل oocyte فإذا كانت مش موجودة مع أن ال oocyte مش هيصير فيها supporting مش هتصل ل ال maturation level هيصير فيها defect يعني apoptosis أو atragia", "tokens": [41185, 2423, 39184, 11745, 6055, 3555, 3615, 2423, 39184, 25483, 14646, 2815, 9154, 11331, 1829, 12984, 2423, 39184, 7316, 4032, 9154, 11331, 1829, 12984, 2423, 1406, 8978, 45030, 11242, 2423, 12961, 5296, 31377, 2304, 6055, 30544, 3714, 29245, 23328, 3660, 6156, 2655, 25957, 1211, 7231, 5296, 39184, 3250, 4032, 3803, 8167, 24976, 277, 31078, 975, 6156, 28814, 15730, 25961, 2655, 37893, 3714, 29245, 23328, 3660, 20449, 14739, 2423, 277, 31078, 975, 37893, 8032, 1829, 9381, 13546, 8978, 11296, 7231, 37893, 8032, 2655, 36520, 5296, 2423, 3803, 8167, 1496, 8032, 1829, 9381, 13546, 8978, 11296, 16445, 37495, 22653, 1882, 5747, 8211, 34051, 412, 3731, 654], "avg_logprob": 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ننتقل إلى ال ovulation خلّينا نخلص فكرة ال spermogenesis كلمنا عن ال oocyte", "tokens": [3224, 4117, 15730, 8717, 30544, 16490, 1211, 9381, 8315, 19446, 7251, 2655, 30241, 4587, 20666, 5172, 32640, 26895, 9154, 11331, 1829, 12984, 6055, 9566, 13063, 2423, 39184, 277, 31078, 975, 34051, 2423, 39184, 25483, 3520, 4032, 2423, 2407, 9381, 12610, 30731, 44650, 1829, 13063, 277, 31078, 975, 8608, 1863, 29399, 4587, 1211, 8978, 15042, 39182, 30731, 6225, 42213, 10632, 2423, 14187, 2776, 4032, 9122, 33911, 6055, 39237, 6225, 42213, 10632, 2423, 14187, 2776, 35525, 19452, 10874, 36150, 19446, 8717, 29399, 4587, 1211, 30731, 2423, 14187, 2776, 16490, 1211, 11703, 9957, 995, 8717, 9778, 1211, 9381, 6156, 4117, 25720, 2423, 32899, 8799, 9374, 9122, 19528, 8315, 18871, 2423, 277, 31078, 975], "avg_logprob": -0.2043918889385086, "compression_ratio": 1.724890829694323, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 512.61, "end": 512.89, "word": "هكذا", "probability": 0.59619140625}, 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ovulation", "probability": 0.6729736328125}, {"start": 526.37, "end": 526.55, "word": " و", "probability": 0.94873046875}, {"start": 526.55, "end": 526.81, "word": " كيف", "probability": 0.931884765625}, {"start": 526.81, "end": 527.25, "word": " تتم", "probability": 0.941650390625}, {"start": 527.25, "end": 527.67, "word": " عملية", "probability": 0.98486328125}, {"start": 527.67, "end": 527.79, "word": " ال", "probability": 0.8671875}, {"start": 527.79, "end": 528.23, "word": " ovulation", "probability": 0.841796875}, {"start": 528.23, "end": 529.07, "word": " ولكن", "probability": 0.825927734375}, {"start": 529.07, "end": 529.37, "word": " جبل", "probability": 0.5562744140625}, {"start": 529.37, "end": 529.67, "word": " ما", "probability": 0.68310546875}, {"start": 529.67, "end": 531.03, "word": " ننتقل", "probability": 0.943115234375}, {"start": 531.03, "end": 531.19, "word": " إلى", "probability": 0.81298828125}, {"start": 531.19, "end": 531.27, "word": " ال", "probability": 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Formation تحت مصطلح spermatogenesis spermatogenesis هي عبارة عن عملية يتم فيها تخليق ال sperm الذي يعرف باسم النطف الذكيرية أو النطف الخاصة بالرجال وهي المسئولة عن عملية الإخصاب بدونها مافي fertilization والمعلومة ماقدر أعمل fertilization ل oocyte من animal", "tokens": [49855, 399, 6055, 33753, 3714, 9381, 9566, 1211, 5016, 422, 8799, 9374, 8032, 29399, 4117, 19528, 18871, 32899, 2513, 4765, 642, 10126, 399, 6055, 33753, 3714, 9381, 9566, 1211, 5016, 32899, 2513, 1766, 9374, 32899, 2513, 1766, 9374, 39896, 6225, 3555, 9640, 3660, 18871, 6225, 42213, 10632, 7251, 39237, 8978, 11296, 6055, 9778, 20292, 4587, 2423, 32899, 43527, 37495, 28480, 4724, 32277, 2304, 28239, 9566, 5172, 32545, 4117, 13546, 10632, 34051, 28239, 9566, 5172, 33962, 33546, 3660, 20666, 47341, 6027, 37037, 1829, 9673, 3794, 19986, 12610, 3660, 18871, 6225, 42213, 10632, 33688, 9778, 9381, 16758, 47525, 11536, 11296, 19446, 41185, 18512, 2144, 4032, 45340, 30241, 20498, 3660, 19446, 28543, 2288, 5551, 25957, 1211, 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"probability": 0.9905598958333334}, {"start": 555.55, "end": 556.11, "word": " الإخصاب", "probability": 0.776611328125}, {"start": 556.11, "end": 556.97, "word": " بدونها", "probability": 0.9620768229166666}, {"start": 556.97, "end": 557.49, "word": " مافي", "probability": 0.867919921875}, {"start": 557.49, "end": 558.41, "word": " fertilization", "probability": 0.779052734375}, {"start": 558.41, "end": 561.73, "word": " والمعلومة", "probability": 0.804541015625}, {"start": 561.73, "end": 562.39, "word": " ماقدر", "probability": 0.6429850260416666}, {"start": 562.39, "end": 562.75, "word": " أعمل", "probability": 0.9358723958333334}, {"start": 562.75, "end": 563.73, "word": " fertilization", "probability": 0.93701171875}, {"start": 563.73, "end": 564.37, "word": " ل", "probability": 0.93994140625}, {"start": 564.37, "end": 565.09, "word": " oocyte", "probability": 0.6866455078125}, {"start": 565.09, "end": 565.35, "word": " من", "probability": 0.99365234375}, {"start": 565.35, "end": 565.83, "word": " animal", "probability": 0.75439453125}], "temperature": 1.0}, {"id": 23, "seek": 59175, "start": 566.21, "end": 591.75, "text": "بال spear من ال human for example لأنه في نوع من أنواع ال specificity بمعنى آخر في receptor موجودة على سطح ال oocyte مخصصة ومصنعة لارتباط بنوع معين من ال spear يكون من نفس المملكة أو من نفس العائلة human human mammalian .. عفوا human human animal animal from the same type", "tokens": [3555, 6027, 26993, 9154, 2423, 1952, 337, 1365, 5296, 33456, 3224, 8978, 8717, 45367, 9154, 14739, 14407, 3615, 2423, 2685, 507, 4724, 2304, 3615, 1863, 7578, 19753, 34740, 8978, 32264, 3714, 29245, 23328, 3660, 15844, 8608, 9566, 5016, 2423, 277, 31078, 975, 3714, 9778, 9381, 9381, 3660, 4032, 2304, 9381, 1863, 27884, 5296, 9640, 2655, 3555, 41193, 44945, 45367, 20449, 9957, 9154, 2423, 26993, 7251, 30544, 9154, 8717, 36178, 9673, 2304, 23275, 3660, 34051, 9154, 8717, 36178, 18863, 16373, 37977, 1952, 1952, 49312, 952, 4386, 6225, 5172, 14407, 1952, 1952, 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{"start": 588.69, "end": 589.33, "word": " animal", "probability": 0.92822265625}, {"start": 589.33, "end": 589.65, "word": " from", "probability": 0.88427734375}, {"start": 589.65, "end": 589.91, "word": " the", "probability": 0.935546875}, {"start": 589.91, "end": 590.41, "word": " same", "probability": 0.921875}, {"start": 590.41, "end": 591.75, "word": " type", "probability": 0.9658203125}], "temperature": 1.0}, {"id": 24, "seek": 62119, "start": 592.95, "end": 621.19, "text": "فبالتالي لازم يكون في عند spermatogenesis فال spermatogenesis هي عبارة عن عملية مطولة يتم فيها تخليق النطف الذكيرية أو النطف الرجال حيث يستطيع الإنتاج ما يقارب من 150 إلى 275 مليون sperm في اليوم الواحد يعني ال normal human الذكر الطبيعي ال human male يستطيع إنتاج 150 إلى 275 مليون sperm في اليوم الواحد", "tokens": [5172, 3555, 6027, 2655, 6027, 1829, 5296, 31377, 2304, 7251, 30544, 8978, 43242, 32899, 2513, 1766, 9374, 6156, 6027, 32899, 2513, 1766, 9374, 39896, 6225, 3555, 9640, 3660, 18871, 6225, 42213, 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"end": 905.34, "text": "في خلايا بنسميها الـ Sertoli cell are involved in all stages of spermatogenesis هذه الـ Sertoli cell خلايا مهمة جدا موجودة في الـ testis و مسئولة وتساهم في كل مرحلة من مراحل تطور الـ sper أو تخليق الـ sper إذا صح التعبير فبالتالي الـ Sertoli cell من الخلايا المهمة التي تتواجد في الـ testis", "tokens": [41185, 16490, 15040, 25528, 44945, 38251, 1829, 11296, 2423, 39184, 318, 911, 9384, 2815, 366, 3288, 294, 439, 10232, 295, 24152, 15677, 8799, 9374, 29538, 2423, 39184, 318, 911, 9384, 2815, 16490, 15040, 25528, 3714, 16095, 3660, 10874, 28259, 3714, 29245, 23328, 3660, 8978, 2423, 39184, 1500, 271, 4032, 47524, 19986, 12610, 3660, 34683, 3794, 995, 16095, 8978, 28242, 3714, 2288, 5016, 37977, 9154, 3714, 23557, 5016, 1211, 6055, 9566, 13063, 2423, 39184, 24152, 34051, 6055, 9778, 20292, 4587, 2423, 39184, 24152, 11933, 15730, 20328, 5016, 16712, 3615, 3555, 13546, 6156, 3555, 6027, 2655, 6027, 1829, 2423, 39184, 318, 911, 9384, 2815, 9154, 33962, 15040, 25528, 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"end": 897.62, "word": " sper", "probability": 0.337890625}, {"start": 897.62, "end": 898.34, "word": " أو", "probability": 0.80126953125}, {"start": 898.34, "end": 899.0, "word": " تخليق", "probability": 0.9503173828125}, {"start": 899.0, "end": 899.16, "word": " الـ", "probability": 0.852294921875}, {"start": 899.16, "end": 899.42, "word": " sper", "probability": 0.89453125}, {"start": 899.42, "end": 899.7, "word": " إذا", "probability": 0.756103515625}, {"start": 899.7, "end": 899.96, "word": " صح", "probability": 0.981201171875}, {"start": 899.96, "end": 900.6, "word": " التعبير", "probability": 0.85400390625}, {"start": 900.6, "end": 901.26, "word": " فبالتالي", "probability": 0.96435546875}, {"start": 901.26, "end": 901.44, "word": " الـ", "probability": 0.849853515625}, {"start": 901.44, "end": 901.84, "word": " Sertoli", "probability": 0.9353841145833334}, {"start": 901.84, "end": 902.2, "word": " cell", "probability": 0.89013671875}, {"start": 902.2, "end": 902.64, "word": " من", "probability": 0.9892578125}, {"start": 902.64, "end": 903.06, "word": " الخلايا", "probability": 0.97265625}, {"start": 903.06, "end": 903.74, "word": " المهمة", "probability": 0.9969075520833334}, {"start": 903.74, "end": 904.1, "word": " التي", "probability": 0.75830078125}, {"start": 904.1, "end": 904.72, "word": " تتواجد", "probability": 0.96123046875}, {"start": 904.72, "end": 904.82, "word": " في", "probability": 0.9765625}, {"start": 904.82, "end": 905.0, "word": " الـ", "probability": 0.900146484375}, {"start": 905.0, "end": 905.34, "word": " testis", "probability": 0.892333984375}], "temperature": 1.0}, {"id": 36, "seek": 93386, "start": 905.54, "end": 933.86, "text": "عند الـ human mail التي تساهم وتشارك في كل مراحل تطوير الـ spermatogenesis حيث أن الـ single sirtol cell الواحدة تعمل على تدعيم إنتاج ما يقارب من 30 إلى 40 sperm cell يعني تصور إنك عندك single cell اسم الـsirtol cell الواحدة قادرة على تدعيم إنتاج خمسين حيوان ملوي لو عندك مليون اضرب المليون في خمسين", 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"الـ Estrogen level بيرتفع بشكل كبير جدا علشان يعطيني دلالة إن والله الفوليكل نضجت ونمت بالشكل المطلوب نضجت ونمت بالشكل المطلوب مباشرة بتبدأ الـ anterior pituitary gland بإفراز هرمون مهم جدا اسمه الـ Lutilizing hormone الـ LH الـ LH هو Lutilizing hormone بمجرد إفرازه يؤثر على الـ Graafian follicle أو الـ Oocyte follicle", "tokens": [6027, 39184, 4410, 7747, 1496, 4724, 13546, 2655, 5172, 3615, 4724, 8592, 28820, 9122, 3555, 13546, 10874, 28259, 11203, 8592, 7649, 37495, 9566, 9957, 1829, 11778, 1211, 6027, 3660, 36145, 16070, 43761, 27188, 12610, 1829, 28820, 8717, 11242, 7435, 2655, 4032, 1863, 2304, 2655, 20666, 8592, 28820, 9673, 9566, 1211, 37746, 8717, 11242, 7435, 2655, 4032, 1863, 2304, 2655, 20666, 8592, 28820, 9673, 9566, 1211, 37746, 3714, 3555, 33599, 25720, 39894, 44510, 10721, 2423, 39184, 22272, 10147, 1983, 822, 43284, 4724, 28814, 5172, 2288, 31377, 8032, 2288, 2304, 11536, 3714, 16095, 10874, 28259, 24525, 2304, 3224, 2423, 39184, 441, 325, 388, 3319, 24211, 2423, 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عملية", "probability": 0.9728190104166666}, {"start": 2674.48, "end": 2675.12, "word": " بتصير", "probability": 0.7705078125}, {"start": 2675.12, "end": 2675.86, "word": " بعد", "probability": 0.9072265625}, {"start": 2675.86, "end": 2676.6, "word": " إفراز", "probability": 0.9278564453125}, {"start": 2676.6, "end": 2676.78, "word": " الـ", "probability": 0.6964111328125}, {"start": 2676.78, "end": 2676.92, "word": " high", "probability": 0.66259765625}, {"start": 2676.92, "end": 2677.32, "word": " peak", "probability": 0.8134765625}, {"start": 2677.32, "end": 2678.96, "word": " للالتش", "probability": 0.68609619140625}], "temperature": 1.0}, {"id": 102, "seek": 270368, "start": 2679.82, "end": 2703.68, "text": "و عندما تم إفراز القلعب بالكمية كبيرة جدا و أعطاني peak أو wave عد 10 إلى 12 ساعة هي المرحلة اللي ممكن يحدث فيها عملية ال ovulation سنتوقف عند هذا الحد في هذه المحاضرة على أمل أن نستكمل في المحاضرة القادمة ان شاء الله", "tokens": [2407, 43242, 15042, 46811, 11933, 5172, 2288, 31377, 25062, 1211, 3615, 3555, 20666, 24793, 10632, 9122, 3555, 48923, 10874, 28259, 4032, 5551, 3615, 9566, 7649, 1829, 10651, 34051, 5772, 6225, 3215, 1266, 30731, 2272, 8608, 995, 27884, 39896, 9673, 2288, 5016, 37977, 13672, 1829, 3714, 43020, 7251, 24401, 12984, 8978, 11296, 6225, 42213, 10632, 2423, 14187, 2776, 8608, 1863, 2655, 30543, 5172, 43242, 23758, 21542, 3215, 8978, 29538, 9673, 5016, 46958, 25720, 15844, 5551, 42213, 14739, 8717, 14851, 24793, 1211, 8978, 9673, 5016, 46958, 25720, 25062, 18513, 46007, 16472, 13412, 16606, 21984], "avg_logprob": -0.26663306451612906, "compression_ratio": 1.608695652173913, "no_speech_prob": 6.496906280517578e-06, "words": [{"start": 2679.82, "end": 2680.06, "word": "و", "probability": 0.440673828125}, {"start": 2680.06, "end": 2680.4, "word": " عندما", "probability": 0.514404296875}, {"start": 2680.4, "end": 2680.68, "word": " تم", "probability": 0.2298583984375}, {"start": 2680.68, "end": 2680.68, "word": " إفراز", "probability": 0.8233642578125}, {"start": 2680.68, "end": 2680.98, "word": " القلعب", "probability": 0.512664794921875}, {"start": 2680.98, "end": 2682.64, "word": " بالكمية", "probability": 0.8660481770833334}, {"start": 2682.64, "end": 2682.94, "word": " كبيرة", "probability": 0.93701171875}, {"start": 2682.94, "end": 2683.28, "word": " جدا", "probability": 0.922607421875}, {"start": 2683.28, "end": 2683.72, "word": " و", "probability": 0.78759765625}, {"start": 2683.72, "end": 2684.2, "word": " أعطاني", "probability": 0.91181640625}, {"start": 2684.2, "end": 2684.54, "word": " peak", "probability": 0.544921875}, {"start": 2684.54, "end": 2685.02, "word": " أو", "probability": 0.7265625}, {"start": 2685.02, "end": 2685.84, "word": " wave", "probability": 0.80126953125}, {"start": 2685.84, "end": 2687.34, "word": " عد", "probability": 0.76904296875}, {"start": 2687.34, "end": 2687.64, "word": " 10", "probability": 0.299560546875}, {"start": 2687.64, "end": 2688.16, "word": " إلى", "probability": 0.4287109375}, {"start": 2688.16, "end": 2688.48, "word": " 12", "probability": 0.96923828125}, {"start": 2688.48, "end": 2688.98, "word": " ساعة", "probability": 0.9065755208333334}, {"start": 2688.98, "end": 2689.42, "word": " هي", "probability": 0.81982421875}, {"start": 2689.42, "end": 2689.96, "word": " المرحلة", "probability": 0.9703369140625}, {"start": 2689.96, "end": 2690.18, "word": " اللي", "probability": 0.734375}, {"start": 2690.18, "end": 2690.52, "word": " ممكن", "probability": 0.761474609375}, {"start": 2690.52, "end": 2690.82, "word": " يحدث", "probability": 0.7515462239583334}, {"start": 2690.82, "end": 2691.08, "word": " فيها", "probability": 0.907470703125}, {"start": 2691.08, "end": 2691.6, "word": " عملية", "probability": 0.9835611979166666}, {"start": 2691.6, "end": 2692.2, "word": " ال", "probability": 0.701171875}, {"start": 2692.2, "end": 2692.72, "word": " ovulation", "probability": 0.6593017578125}, {"start": 2692.72, "end": 2696.72, "word": " سنتوقف", "probability": 0.736572265625}, {"start": 2696.72, "end": 2696.92, "word": " عند", "probability": 0.6748046875}, {"start": 2696.92, "end": 2697.14, "word": " هذا", "probability": 0.80810546875}, {"start": 2697.14, "end": 2697.48, "word": " الحد", "probability": 0.767822265625}, {"start": 2697.48, "end": 2697.88, "word": " في", "probability": 0.92333984375}, {"start": 2697.88, "end": 2698.1, "word": " هذه", "probability": 0.65087890625}, {"start": 2698.1, "end": 2698.66, "word": " المحاضرة", "probability": 0.9884033203125}, {"start": 2698.66, "end": 2699.2, "word": " على", "probability": 0.88232421875}, {"start": 2699.2, "end": 2699.58, "word": " أمل", "probability": 0.94580078125}, {"start": 2699.58, "end": 2700.14, "word": " أن", "probability": 0.83251953125}, {"start": 2700.14, "end": 2700.76, "word": " نستكمل", "probability": 0.967529296875}, {"start": 2700.76, "end": 2700.88, "word": " في", "probability": 0.8955078125}, {"start": 2700.88, "end": 2701.52, "word": " المحاضرة", "probability": 0.99072265625}, {"start": 2701.52, "end": 2702.34, "word": " القادمة", "probability": 0.9939778645833334}, {"start": 2702.34, "end": 2702.92, "word": " ان", "probability": 0.51806640625}, {"start": 2702.92, "end": 2703.36, "word": " شاء", "probability": 0.9697265625}, {"start": 2703.36, "end": 2703.68, "word": " الله", "probability": 0.94140625}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2759.5523125, "duration_after_vad": 2665.086874999991}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/9mspvrq6uv4.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/9mspvrq6uv4.srt
new file mode 100644
index 0000000000000000000000000000000000000000..7e7ebb3413ed066bf97070b0161ad8fc7afef585
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/9mspvrq6uv4.srt
@@ -0,0 +1,2595 @@
+1
+00:00:00,570 --> 00:00:04,290
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:04,290 --> 00:00:09,550
+المرسلين سيدنا محمد وعلى آله وصحبه أجمعين طلابنا 
+
+3
+00:00:09,550 --> 00:00:13,330
+الأعزاء نرجو من الله الكريم أن تكونوا جميعا بخير
+
+4
+00:00:13,330 --> 00:00:18,670
+وبصحة جيدة تحدثنا في المحاضرة السابقة عن فحص يعتبر 
+
+5
+00:00:18,670 --> 00:00:22,550
+من أهم الفحوصات التي تستخدم في تقييم قدرة الرجل 
+
+6
+00:00:22,550 --> 00:00:26,650
+على الإنجاب وهو فحص تحليل السائل المنوي تحت مصطلح
+
+7
+00:00:26,650 --> 00:00:31,760
+Seminal Analysis  قررنا خلال الحديث عن هذا الفحص عن
+
+8
+00:00:31,760 --> 00:00:37,540
+عدة معايير مهمة كالـ volume  الـ pH  الـ viscosity  الـ
+
+9
+00:00:37,540 --> 00:00:41,540
+concentration  الـ count  الـ motility بأقسامها 
+
+10
+00:00:41,540 --> 00:00:45,280
+متمثلة في الـ progressive motile  الـ non 
+
+11
+00:00:45,280 --> 00:00:48,120
+progressive motile  الـ non motile spermatozoa 
+
+12
+00:00:48,120 --> 00:00:51,820
+انتقلنا للحديث عن الـ morphology  انتقلنا للحديث عن 
+
+13
+00:00:51,820 --> 00:00:56,060
+بعض الفحوصات المتعلقة بنشاط الـ sperm زي الـ
+
+14
+00:00:56,060 --> 00:01:00,070
+fructose test  هذه معظمها فحوصات لها علاقة بالـ
+
+15
+00:01:00,070 --> 00:01:04,610
+Seminal Fluid  جميعها يتم إجراءها و يتم إنجازها في 
+
+16
+00:01:04,610 --> 00:01:09,990
+المختبر وبعضها لا يتم تطرق إليها مثل فحص الفركتوز
+
+17
+00:01:09,990 --> 00:01:15,350
+على سبيل المثال اليوم سوف نتحدث عن موضوع جديد له
+
+18
+00:01:15,350 --> 00:01:19,930
+علاقة بالآلية المتبعة و الطرق المستخدمة لتحضير 
+
+19
+00:01:19,930 --> 00:01:24,170
+عينة السائل للحقن المجهري أو للتلقيح الصناعي
+
+20
+00:01:24,170 --> 00:01:30,490
+التقليدي المسمى باسم IVF In Vitro Fertilization
+
+21
+00:01:30,490 --> 00:01:36,590
+ولكن قبل أن نتحدث عن هذه الآليات وهذه الطرق التي 
+
+22
+00:01:36,590 --> 00:01:40,890
+يمكن أن تستخدم من أجل تحضير عينة السائل دعونا
+
+23
+00:01:40,890 --> 00:01:45,750
+نتكلم عن مصطلحات طبية مهمة جداً لها علاقة بالـ XY
+
+24
+00:01:45,750 --> 00:01:51,510
+ولها علاقة بالـ Seminal Fluid  من أشهرها Aspermia
+
+25
+00:01:51,510 --> 00:01:56,170
+فالـ Aspermia معناها انعدام وجود seminal fluid هذا 
+
+26
+00:01:56,170 --> 00:02:00,350
+الرجل لا يستطيع أن يعمل ejaculation فبالتالي في
+
+27
+00:02:00,350 --> 00:02:03,390
+عنده seminal fluid ال volume الخاص فيه zero مافي 
+
+28
+00:02:03,390 --> 00:02:07,770
+عنده seminal أو semen volume مافي عنده semen
+
+29
+00:02:07,770 --> 00:02:12,150
+volume so the definition of Aspermia is no
+
+30
+00:02:12,150 --> 00:02:17,190
+seminal fluid وينطبق عليها مصطلحين hypospermia
+
+31
+00:02:17,190 --> 00:02:21,120
+وhyperspermia الـ Hyper-Spermia زيادة في الـ volume
+
+32
+00:02:21,120 --> 00:02:26,660
+في الحجم بتجاوز الـ 5.5 ملي لتر أما الـ Hypo
+
+33
+00:02:26,660 --> 00:02:31,780
+-Spermia نقصان في الـ volume لكي يكون أقل من 2 ملي
+
+34
+00:02:31,780 --> 00:02:35,240
+لتر لأننا اتفقنا أن الـ normal volume للـ seminal
+
+35
+00:02:35,240 --> 00:02:40,820
+fluid 2 ملي لتر فزيادته و نقصانه له مصطلح معين
+
+36
+00:02:40,820 --> 00:02:46,400
+يليه مصطلح مهم جدا و هو أكثر انتشارا هو عبارة عن 
+
+37
+00:02:46,400 --> 00:02:50,530
+الـ Oligospermia الـ Ologospermia معناها نقصان في
+
+38
+00:02:50,530 --> 00:02:54,410
+عدد الحيوانات المنوية في كل واحد مليليتر لكي تصل
+
+39
+00:02:54,410 --> 00:02:59,590
+إلى أقل من 20 مليون حيوان في المليلتر الواحد يليه
+
+40
+00:02:59,590 --> 00:03:04,150
+مصطلح مهم ويعتبر من المصطلحات الأكثر انتشارا و
+
+41
+00:03:04,150 --> 00:03:08,170
+الأهم وهي مصطلح الـ Azospermia فالـ Azospermia
+
+42
+00:03:08,170 --> 00:03:12,350
+معناها عدم وجود سبيرماتوزوة في الـ seminal fluid 
+
+43
+00:03:12,350 --> 00:03:18,070
+so the lack of sperm in the semen  جدش بتتمثل هذه
+
+44
+00:03:18,070 --> 00:03:23,390
+العملية وهذا المصطلح مصطلح الازوسبيرميا يمثل 2% أو
+
+45
+00:03:23,390 --> 00:03:29,170
+يتواجد بمعدل 2% من ال total males population يعني
+
+46
+00:03:29,170 --> 00:03:33,870
+بمعنى أخر كل 100 male وكل 100 men فيهم اثنين
+
+47
+00:03:33,870 --> 00:03:38,070
+مصابين بالازوسبيرميا أيضا وجدوا أن الازوسبيرميا
+
+48
+00:03:38,070 --> 00:03:43,490
+تتواجد بمعدل 10-15% من الذكور المشخصين بأنهم 
+
+49
+00:03:43,490 --> 00:03:47,710
+infertile هذا المصطلح مصطلح مهم وخاطر في نفس
+
+50
+00:03:47,710 --> 00:03:51,790
+اللحظة خدوا بالك في مصطلحين إنهم علاقة بال
+
+51
+00:03:51,790 --> 00:03:56,070
+azospermia azospermia as general term و azospermia 
+
+52
+00:03:56,070 --> 00:04:02,230
+after centrifugation ال azospermia as general term
+
+53
+00:04:02,230 --> 00:04:05,490
+إنه تكنولوجيست عامل scanning للشريحة مالجاش فيها 
+
+54
+00:04:05,490 --> 00:04:08,410
+sperm وضع إنه عدد ال sperm zero فبالتالي 
+
+55
+00:04:08,410 --> 00:04:12,530
+azospermia في تكنولوجيست أخر و embryologist أخر 
+
+56
+00:04:12,530 --> 00:04:16,840
+أكثر دراية بالعمل فأخد العينة ك total sample وضعها 
+
+57
+00:04:16,840 --> 00:04:19,960
+في test tube وعملها centrifugation أخد جزء من ال
+
+58
+00:04:19,960 --> 00:04:24,800
+sediment وعملها scanning ما وجد sperm فبيسميه
+
+59
+00:04:24,800 --> 00:04:29,060
+azospermia after centrifugation وهو المصطلح الأدق
+
+60
+00:04:29,060 --> 00:04:32,960
+لأن ممكن أنا لما أعمل mixing و أخد 50 micro أو 10
+
+61
+00:04:32,960 --> 00:04:35,780
+micro و أعملها scanning ومالاجيش لو أنا عملت 
+
+62
+00:04:35,780 --> 00:04:39,020
+mixing كويس أو عملت centrifugation للعينة يعني
+
+63
+00:04:39,020 --> 00:04:42,650
+جمعتها ورصبتها وعملت لها concentrationو أخدت من الـ
+
+64
+00:04:42,650 --> 00:04:45,650
+sediments ممكن ألاقي sperm أو اثنين أو ثلاثة لأن 
+
+65
+00:04:45,650 --> 00:04:50,130
+هذا بيأثر على طبيعة علاج المريض فيما بعد فمهم جدا
+
+66
+00:04:50,130 --> 00:04:54,070
+بعد ما ألاقي مصطلح Azospermia في العينة و أعمل فحص 
+
+67
+00:04:54,070 --> 00:04:56,930
+للعينة و ألاقيها Azospermia أعملها centrifugation 
+
+68
+00:04:56,930 --> 00:05:00,710
+و أفحصها مرة ثانية عشان أقول Azospermia after
+
+69
+00:05:00,710 --> 00:05:04,030
+centrifugation أو لاقيت واحد sperm after
+
+70
+00:05:04,030 --> 00:05:08,150
+centrifugation فهذا المصطلح مهم جدا هنتكلم عنه لما
+
+71
+00:05:08,150 --> 00:05:11,310
+نصل إلى الـ testicular biopsy كيف المصطلح
+
+72
+00:05:11,310 --> 00:05:15,570
+الازوسبيرميا after centrifugation بلعب دور كبير 
+
+73
+00:05:15,570 --> 00:05:20,830
+ومهم في تحديد هل هذا الذكر أو هذا الرجل يلجأ إلى
+
+74
+00:05:20,830 --> 00:05:24,310
+ال testicular biopsy أو لا وإن لجأ إلى ال
+
+75
+00:05:24,310 --> 00:05:27,450
+testicular biopsy ما طبيعة ال biopsy هنتكلم في
+
+76
+00:05:27,450 --> 00:05:31,810
+عندي أربعة أنواع أسبابها بشكل أساسي أسباب 
+
+77
+00:05:31,810 --> 00:05:35,150
+الازوسبيرميا قد تكون ال blockage على طول ال
+
+78
+00:05:35,150 --> 00:05:38,280
+reproductive tract أو قد يكون عندي abnormality في 
+
+79
+00:05:38,280 --> 00:05:41,700
+ال hormone level وأشهرهم in FSH and LH testosterone
+
+80
+00:05:41,700 --> 00:05:45,040
+قد يكون عندي مشكلة في ال ejaculatory duct قد يكون 
+
+81
+00:05:45,040 --> 00:05:48,820
+عندي مشكلة أساسية وظيفية أو تركيبية في ال
+
+82
+00:05:48,820 --> 00:05:52,580
+testicular وال testicular أو ال testis هي المصنع 
+
+83
+00:05:52,580 --> 00:05:57,620
+الأساسي لإنتاج الاسبيرميا وبناء على هذا تم تقسيم 
+
+84
+00:05:57,620 --> 00:06:01,880
+الاسبيرميا إلى قسمين أساسيين obstructive aspermia 
+
+85
+00:06:01,880 --> 00:06:07,400
+و non-obstructive aspermia فطالما تم تقسيم الـ
+
+86
+00:06:07,400 --> 00:06:09,700
+Azospermia إلى Obstructive وNon-obstructive
+
+87
+00:06:09,700 --> 00:06:13,720
+Azospermia ما هو الفرق؟ ما هو الفرق بين الـ
+
+88
+00:06:13,720 --> 00:06:17,020
+Obstructive وNon-obstructive Azospermia؟ الـ
+
+89
+00:06:17,020 --> 00:06:21,620
+Obstructive Azospermia وجدوا أن أكثر أسباب وجودها 
+
+90
+00:06:21,620 --> 00:06:26,560
+هي عبارة عن Blockage في الـ Vas Deferens أو الـ
+
+91
+00:06:26,560 --> 00:06:29,780
+Epididymis أو الـ Ejaculatory Duct فقط Blockage؟ لأ 
+
+92
+00:06:30,010 --> 00:06:33,150
+واجهته ممكن يكون سبب آخر إن الـ Congenital Absence 
+
+93
+00:06:33,150 --> 00:06:37,190
+في الـ Vas Deferens إبداد Epididymis وإيجاكلوتريدارت
+
+94
+00:06:37,190 --> 00:06:39,650
+تبشوفوا الفرق بين ال blockage و الcongenital
+
+95
+00:06:39,650 --> 00:06:43,270
+absence ال blockage إن هذا علم الذكر أو هذا الرجل
+
+96
+00:06:43,270 --> 00:06:46,990
+تعرض إلى حادث معين عمل وجود blockage وانسداد في
+
+97
+00:06:46,990 --> 00:06:50,170
+هذه القنوات المذكورة الثلاثة أما الcongenital
+
+98
+00:06:50,170 --> 00:06:55,290
+absence .. absence .. absence وهو إن ال male خلق 
+
+99
+00:06:55,290 --> 00:07:00,610
+وولد وجاء على قيد الحياة وماعندهوش هذه المركبات أو
+
+100
+00:07:00,610 --> 00:07:03,510
+واحد منهم ماعندهوش الـ Epididymis ماعندهوش ال vast
+
+101
+00:07:03,510 --> 00:07:06,630
+difference وماعندهوش ال ejaculatory duct وارد صحيح 
+
+102
+00:07:06,630 --> 00:07:11,390
+وارد ماهي المشاكل والأسباب التي تؤدي إلى حدوث ال
+
+103
+00:07:11,390 --> 00:07:13,990
+blockage بشكل أساسي لأن ال blockage يُعتبر هو
+
+104
+00:07:13,990 --> 00:07:18,350
+الأكثر انتشارا من أشهر الأسباب في عندي trauma أو 
+
+105
+00:07:18,350 --> 00:07:21,810
+injury في منطقة .. في منطقة خاصة بال reproductive
+
+106
+00:07:21,810 --> 00:07:26,650
+tract infection أو inflammation في عندي عملية 
+
+107
+00:07:26,650 --> 00:07:29,680
+جراحية في منطقة ال pelvic area في عندي الـ
+
+108
+00:07:29,680 --> 00:07:32,800
+vasectomy وهو إن الـ vas deference تعرض للاستئصال
+
+109
+00:07:32,800 --> 00:07:39,700
+ذكر رجل مصاب بـ cystic fibrosis أو mutation في 
+
+110
+00:07:39,700 --> 00:07:43,040
+الجين الخاص بالـ cystic fibrosis فهذا الـ mutation
+
+111
+00:07:43,040 --> 00:07:47,600
+أدى إلى حدوث مشكلة في الـ vas deferens مما أدى 
+
+112
+00:07:47,600 --> 00:07:51,400
+إلى وجود مشكلة في تطور الـ vas deferens فأدى إلى 
+
+113
+00:07:51,400 --> 00:07:56,100
+حدوث blockage في الـ vas deferens بشكل أساسي إذن،
+
+114
+00:07:56,100 --> 00:07:59,770
+بناء على هذا الكلام في أسباب معينة علاقة بالـ
+
+115
+00:07:59,770 --> 00:08:05,770
+Obstructive Azospermia وتطرقنا إليها بشكل و بآخر و
+
+116
+00:08:05,770 --> 00:08:08,010
+من أشهر اللي قلنا عنها هي الـ Blockage في الـ 
+
+117
+00:08:08,010 --> 00:08:11,270
+Vasodifference اللي بتدمس و النوع الثاني الـ
+
+118
+00:08:11,270 --> 00:08:14,730
+Ejaculatory duct واحد منهم أو الثلاثة مع بعض نجي
+
+119
+00:08:14,730 --> 00:08:18,990
+للشق الآخر من أنواع الـ Azospermia اللي حكيناها
+
+120
+00:08:18,990 --> 00:08:22,430
+Non-obstructive Azospermia والمعصود بالـ Non
+
+121
+00:08:22,430 --> 00:08:26,690
+-obstructive Azospermia أن الثلاثة مركبات
+
+122
+00:08:26,690 --> 00:08:29,710
+الأساسية أو التركيبات الثلاثة الأساسية سواء كان
+
+123
+00:08:29,710 --> 00:08:31,950
+الـ Epididymis أو الـBase Difference أو
+
+124
+00:08:31,950 --> 00:08:35,250
+الـEjaculatory Duct بيكونوا سالمين 100% ما في
+
+125
+00:08:35,250 --> 00:08:40,720
+عندهم Blockage ولكن في أسباب أخرى عبارة عن أسباب 
+
+126
+00:08:40,720 --> 00:08:48,560
+جانبية أدت إلى إنقاص معدل إنتاج الـ sperm فبالتالي 
+
+127
+00:08:48,560 --> 00:08:51,260
+هذه الـ external factor أو الـ other factor هي 
+
+128
+00:08:51,260 --> 00:08:56,140
+اللي أثرت على المصنع بشكل أساسي ولم تؤثر على عوامل 
+
+129
+00:08:56,140 --> 00:09:00,040
+أخرى خلينا نشوف إيش ممكن الأسباب التي تؤدي إلى
+
+130
+00:09:00,040 --> 00:09:03,520
+الـ non-obstructive azospermia الـ non-obstructive
+
+131
+00:09:03,520 --> 00:09:07,760
+azospermia المقصود فيها أن الثلاثة تركيبات الأساسية
+
+132
+00:09:07,760 --> 00:09:11,120
+اللي اتكلمنا عليها Vas deferens Epididymis Ejaculatory
+
+133
+00:09:11,120 --> 00:09:15,320
+duct Normal there is no blockage in this tubule or
+
+134
+00:09:15,320 --> 00:09:19,160
+in this tract ولكن there is another external
+
+135
+00:09:19,160 --> 00:09:23,140
+factor أثرت على الـ testis بشكل أساسي منها الـ
+
+136
+00:09:23,140 --> 00:09:29,800
+genetic causes أسباب وراثية من أشهرها الـ Klinefelter
+
+137
+00:09:29,800 --> 00:09:33,620
+والـ Klinefelter هو عبارة عن male with two copies
+
+138
+00:09:33,620 --> 00:09:38,270
+of X chromosome فهذا يؤدي إلى وجود ضمور في الـ
+
+139
+00:09:38,270 --> 00:09:41,230
+testis مما يؤدي إلى إنقاص معدل إنتاج الـ spermia 
+
+140
+00:09:41,230 --> 00:09:44,750
+أيضا من أسباب الوراثية التي تؤدي إلى non
+
+141
+00:09:44,750 --> 00:09:47,030
+-obstructive azospermia أو بشكل أساسي الـ
+
+142
+00:09:47,030 --> 00:09:50,570
+azospermia ولكن non-obstructive هي وجود micro
+
+143
+00:09:50,570 --> 00:09:53,710
+-deletion في الـ Y-Chromosome لأن الـ Y-Chromosome 
+
+144
+00:09:53,710 --> 00:09:58,750
+يحتوي على جينات تلعب دورًا مهمة وأساسية وحساسة في
+
+145
+00:09:58,750 --> 00:10:02,820
+إنتاج الحيوانات المنوية، فلو صار microdeletion في
+
+146
+00:10:02,820 --> 00:10:06,000
+الـY كرمز وملاجينات أساسية معناه لـ production
+
+147
+00:10:06,000 --> 00:10:10,560
+rate will be declined، هرمون abnormality or
+
+148
+00:10:10,560 --> 00:10:14,820
+imbalance، ومن أشهر هذه الحالات وجود ما يُعرف باسمه
+
+149
+00:10:14,820 --> 00:10:18,940
+الـ Hypogonadotropic، Hypogonadotropic يعني نقصان
+
+150
+00:10:18,940 --> 00:10:22,700
+في مستوى الهرمونات التي تفرز من مناطق معينة، الجناد
+
+151
+00:10:22,700 --> 00:10:27,240
+ومن أشهر هذه الهرمونات التستوستيرون الذي يلعب دورًا
+
+152
+00:10:27,240 --> 00:10:33,090
+مهمة في إنتاج وتطور ونضوج الحيوانات المنوية أيضًا
+
+153
+00:10:33,090 --> 00:10:38,130
+Hypogonadism، من حيث الـGonadism أيضًا من أشهر
+
+154
+00:10:38,130 --> 00:10:44,830
+الأسباب أيضًا Hyperprolactinemia،
+
+155
+00:10:44,830 --> 00:10:49,650
+بمعنى آخر زيادة مستوى هرمون البرولاكتين، زي ما
+
+156
+00:10:49,650 --> 00:10:52,810
+البرولاكتين بيعمل infertility مؤقت عند الفيميل،
+
+157
+00:10:52,810 --> 00:10:56,310
+أيضًا البرولاكتين قد يؤدي ويعمل بشكل سلبي على
+
+158
+00:10:56,310 --> 00:11:00,070
+المادة، فبالتالي لازم للبرولاكتين يصير فيه عنده
+
+159
+00:11:00,690 --> 00:11:04,390
+عملية معالجة في حالة ارتفاعه، من أسباب الهرمونية
+
+160
+00:11:04,390 --> 00:11:07,890
+أيضًا الـ Androgen-resistant، أنه في عندي Androgen
+
+161
+00:11:07,890 --> 00:11:11,590
+-hormone وفي عندي Sex-hormone ولكن الـ Receptor مش
+
+162
+00:11:11,590 --> 00:11:15,230
+شغال عشان يستقبله، فبالتالي لا يؤدي الوظيفة المطلوبة،
+
+163
+00:11:15,230 --> 00:11:19,650
+فيه سبب ثاني من أسباب الـ Azoospermia، ولكن الـ Non
+
+164
+00:11:19,650 --> 00:11:23,250
+-obstructive Azoospermia، سيرتولي سيل Only Syndrome،
+
+165
+00:11:23,250 --> 00:11:26,990
+وهي عبارة عن مشكلة في السيرتولي سيل التي تلعب
+
+166
+00:11:26,990 --> 00:11:31,540
+دورًا مهمة في تطور ونضوج الحيوانات المنوية،
+
+167
+00:11:31,540 --> 00:11:38,220
+spermatogenic arrest، تستكل failure to produce full
+
+168
+00:11:38,220 --> 00:11:43,180
+mature sperm cell، أنه تستشغالة ولكن في عندها ضعف
+
+169
+00:11:43,180 --> 00:11:46,780
+في منطقة معينة أو في مرحلة معينة من مراحل التطور
+
+170
+00:11:46,780 --> 00:11:50,600
+ونضوج الحيوانات المنوية، فبالتالي بيعطيني sperm،
+
+171
+00:11:50,600 --> 00:11:55,600
+ولكن هذا ال sperm لا يكون ناضج بالشكل المطلوب أو
+
+172
+00:11:55,600 --> 00:12:01,400
+بالكيفية المطلوبة، سبب آخر من أسباب الـ azoospermia
+
+173
+00:12:01,400 --> 00:12:05,640
+ولكن الـ non-obstructive، ال trauma، ال radiation، ال
+
+174
+00:12:05,640 --> 00:12:09,760
+varicocele أيضًا، كيدنفيريا، ال diabetes .. ال
+
+175
+00:12:09,760 --> 00:12:13,480
+diabetic أو ال diabetes، ال cirrhosis، هذه كلها
+
+176
+00:12:13,480 --> 00:12:18,300
+تعتبر من الأسباب التي تؤدي وتساهم في حدود ال non
+
+177
+00:12:18,300 --> 00:12:20,740
+-obstructive azoospermia، ال non-obstructive
+
+178
+00:12:20,740 --> 00:12:25,260
+azoospermia في مصطلح ثاني من المصطلحات الطبية
+
+179
+00:12:25,260 --> 00:12:31,460
+المهمة asthenozoospermia، وهذا المصطلح مقصود فيه
+
+180
+00:12:31,460 --> 00:12:36,880
+أنه فيها عندي ك technologist عندي عينات، عينات هذه
+
+181
+00:12:36,880 --> 00:12:41,220
+فيها sperm motility أو sperm motile، ولكن في عندي
+
+182
+00:12:41,220 --> 00:12:45,900
+reduction في كمية ونسبة الحيوانات المنوية المتحركة،
+
+183
+00:12:45,900 --> 00:12:51,260
+حتى تصل إلى أقل من 40%، ورغم أنه ال normal range ل
+
+184
+00:12:51,260 --> 00:12:57,430
+ال total motile 42%، عفوا 40%، بس لـ Progressive 32%،
+
+185
+00:12:57,430 --> 00:13:00,210
+فبالتالي لو صار في عندي reduction in the
+
+186
+00:13:00,210 --> 00:13:05,390
+percentage of total sperm motile less than 40%، هذا
+
+187
+00:13:05,390 --> 00:13:09,870
+المصطلح بسميه asthenozoospermia، طب شو أسبابه؟ شو
+
+188
+00:13:09,870 --> 00:13:13,670
+العوامل الممكن تسبب وتأثر على ال sperm motility؟
+
+189
+00:13:13,670 --> 00:13:17,290
+في عندي عدة عوامل، من أول عوامل التي تؤثر سلبًا عن
+
+190
+00:13:17,290 --> 00:13:21,670
+ال sperm motility، ال Varicocele دوال الخصية، خدوا
+
+191
+00:13:21,670 --> 00:13:25,290
+بالك، ال Varicocele هو عبارة عن تضخم في بعض الأوردة أو
+
+192
+00:13:25,290 --> 00:13:30,690
+التي تحيط بالـ testes، تعتبر reversible بمعنى آخر
+
+193
+00:13:30,690 --> 00:13:35,910
+أنه ممكن يصير علاج إلها وترجع مرة ثانية، هذا يعتبر
+
+194
+00:13:35,910 --> 00:13:39,930
+مشكلة مؤقتة تزال بعملية جراحية، في عندي مشكلة أيضًا
+
+195
+00:13:39,930 --> 00:13:43,710
+seminal tract infection، في عندي antisperm antibody،
+
+196
+00:13:43,710 --> 00:13:47,190
+لأن الـ antibody هيعمل قتل للـ sperm ويفقد قدرته
+
+197
+00:13:47,190 --> 00:13:51,310
+على حركة، فيما بيعمل reduction، poor nutrition، عندي
+
+198
+00:13:51,310 --> 00:13:54,380
+مشكلة في التخزينة، ما عنده كمية كافية من ال fructose،
+
+199
+00:13:54,380 --> 00:13:58,400
+ما بتناول فواكه بكمية كافية، ما بتناول مصادر ال
+
+200
+00:13:58,400 --> 00:14:01,980
+fructose، فبالتالي هيفقد ال sperm قدرته على الحركة،
+
+201
+00:14:01,980 --> 00:14:07,460
+بسبب فقدانه العنصر الأساسي للحركة، ال smoking، ال
+
+202
+00:14:07,460 --> 00:14:10,280
+alcohol intake، ال caffeine، ال tobacco consumption،
+
+203
+00:14:10,280 --> 00:14:17,020
+هذا كلها تعتبر من أسباب التي تؤدي إلى نقصان مستوى
+
+204
+00:14:17,020 --> 00:14:23,560
+ونسبة حركة الحيوانات المنوية، هذه بشكل أساسي من
+
+205
+00:14:23,560 --> 00:14:28,060
+الأسباب الأخرى التي تساهم في نقصان معدل ونسبة تحرك
+
+206
+00:14:28,060 --> 00:14:31,840
+الحيوانات المنوية هو التعرض لبعض الـ toxic agents،
+
+207
+00:14:31,840 --> 00:14:36,740
+زي الناس الـ farmers، الناس اللي بتشتغل في البنزينة،
+
+208
+00:14:36,740 --> 00:14:38,960
+الناس اللي بتشتغل كمزارعين، الناس اللي بتشتغل في
+
+209
+00:14:38,960 --> 00:14:43,120
+مصنع البطاريات، الناس اللي بتشتغل في المناجم الفحم،
+
+210
+00:14:43,120 --> 00:14:46,820
+تتعرض لكمية كبيرة جدا من ال organic solvent أو
+
+211
+00:14:46,820 --> 00:14:51,470
+المواد التي تعتبر مواد سامة، المشكلة ليست في التعرض،
+
+212
+00:14:51,470 --> 00:14:54,030
+المشكلة في كمية التعرض ووقت التعرض وال
+
+213
+00:14:54,030 --> 00:14:56,350
+concentration اللي بتتعرض إليه الإنسان، يعني ممكن
+
+214
+00:14:56,350 --> 00:14:59,250
+أي إنسان، إحنا في حياتنا اليوم دي متعرضين، ولكن مش كلنا
+
+215
+00:14:59,250 --> 00:15:01,910
+متعرضين، أنت ممكن تتعرض ساعة، من إزاي اللي بيشتغل
+
+216
+00:15:01,910 --> 00:15:04,870
+في البنزينة بدوام 12 ساعة؟ ومش اللي بيشتغل في
+
+217
+00:15:04,870 --> 00:15:09,110
+الفحم وفي منجم الفحم بدوام ممكن يصل إلى 24 ساعة،
+
+218
+00:15:09,110 --> 00:15:12,710
+متواصل أو متقطع، فبالتالي في عنده duration لل
+
+219
+00:15:12,710 --> 00:15:18,750
+exposure، كمية، وقت عالي جدًا، فبيعمل مشاكل في ال
+
+220
+00:15:18,750 --> 00:15:22,970
+sperm motility، أيضًا الـ Age بيلعب دور عكسي في
+
+221
+00:15:22,970 --> 00:15:29,390
+وجهة الدراسات أن هناك علاقة سلبية ما بين الـ Age
+
+222
+00:15:29,390 --> 00:15:34,870
+و percentage of sperm motility، تحت مصطلح Negative
+
+223
+00:15:34,870 --> 00:15:37,690
+Correlation between the Male Age and the
+
+224
+00:15:37,690 --> 00:15:41,130
+Percentage of Sperm Motile، كل ما زاد ال Age قل
+
+225
+00:15:41,130 --> 00:15:44,510
+الموتيلتي، كل ما قل ال Age زاد الموتالي ال sperm،
+
+226
+00:15:44,510 --> 00:15:48,170
+أيضًا ال Cancer بيلعب دور سلبي، لأنه طول ما في عندي
+
+227
+00:15:48,170 --> 00:15:50,540
+Cancer في عند الـ Radiotherapy، في عند الـ
+
+228
+00:15:50,540 --> 00:15:55,000
+Chemotherapy، وكلهم يؤثر سلبًا على مصنع الحيوانات
+
+229
+00:15:55,000 --> 00:15:57,980
+المنوية وفيؤثر سلبًا على الحيوانات المنوية
+
+230
+00:15:57,980 --> 00:16:00,600
+الموجودة في الـ epididymis، ويؤثر سلبًا على
+
+231
+00:16:00,600 --> 00:16:04,740
+الحيوانات المنوية التي ما زالت تُخلق، فبالتالي، دي
+
+232
+00:16:04,740 --> 00:16:09,180
+بيعمل reduction عندي في عدد ال sperm المتحركة في
+
+233
+00:16:09,180 --> 00:16:13,540
+عنده مصطلح آخر اسمه Teratospermia، ما المقصود بهذا
+
+234
+00:16:13,540 --> 00:16:18,320
+المصطلح؟ Teratospermia معناه إن في أنا عندي sperm في
+
+235
+00:16:18,320 --> 00:16:22,980
+عندي spermatozoa وفي عندي mature sperm، ولكن معدل
+
+236
+00:16:22,980 --> 00:16:28,560
+ال .. أو نسبة .. نسبة ال sperm اللي يعتبر up
+
+237
+00:16:28,560 --> 00:16:32,360
+normal form عالي جدًا، up normal form يعني ميجارو
+
+238
+00:16:32,360 --> 00:16:36,060
+head، pin head، double tail، two mid piece، يعني
+
+239
+00:16:36,060 --> 00:16:40,440
+بمعنى آخر أنا عملت scanning للعينة، لقيت عدد ومستوى
+
+240
+00:16:40,440 --> 00:16:44,240
+ونسبة ومعدل تواجد ال up normal form spermatozoa
+
+241
+00:16:44,240 --> 00:16:49,850
+عالي جدًا، بالتالي بسميها Teratospermia، Teratospermia،
+
+242
+00:16:49,850 --> 00:16:53,530
+شو أسبابها؟ شو ال most common؟ شو الفكرة التي تؤدي
+
+243
+00:16:53,530 --> 00:16:58,010
+إلى حدوث Teratospermia؟ أول حاجة ال infection، ال
+
+244
+00:16:58,010 --> 00:17:01,650
+chronic infection، كل ما اتعرضت أو هنعرف إيش عن ال
+
+245
+00:17:01,650 --> 00:17:05,250
+chronic infection أو كيف ال chronic infection بسبب
+
+246
+00:17:05,250 --> 00:17:09,790
+تغييب في أشكال الحيوانات، خدوا بالكوا، اربطوها وهنتكلم
+
+247
+00:17:09,790 --> 00:17:12,770
+عنها بشكل مستفيض، تكلمنا عن المحاضرة الفاتتة،
+
+248
+00:17:13,100 --> 00:17:15,660
+chronic infection يعني ال immune system هيشتغل،
+
+249
+00:17:15,660 --> 00:17:19,560
+يعني في عندي white blood cells هتهاجر للمنطقة هذه، هتفرز
+
+250
+00:17:19,560 --> 00:17:22,720
+ال white blood cells كمية كبيرة جدا من ال free radical،
+
+251
+00:17:22,720 --> 00:17:27,380
+فتديني ROS، Reactive Oxygen Species، هذي بتعملي
+
+252
+00:17:27,380 --> 00:17:30,780
+degradation في ال DNA وفي ال morphology بتاعة ال
+
+253
+00:17:30,780 --> 00:17:35,040
+sperm، ببساطة جدًا، Smoking وال alcohol intake تؤدي
+
+254
+00:17:35,040 --> 00:17:39,600
+إلى Teratospermia، عدم وجود اتزان وتناول طعام صحي
+
+255
+00:17:39,600 --> 00:17:43,250
+تؤدي إلى Teratospermia، الـ Obesity تعتبر من أهم
+
+256
+00:17:43,250 --> 00:17:46,730
+العوامل التي تساعد في وجود Teratospermia، الـ Drug
+
+257
+00:17:46,730 --> 00:17:51,830
+الذي يتم تناوله بغير وصفة طبية أو بغير جرعة طبية،
+
+258
+00:17:51,830 --> 00:17:55,210
+بعض الأدوية تؤثر سلبًا أيضًا، وجود ال trauma في
+
+259
+00:17:55,210 --> 00:17:59,610
+منطقة ال testicular تؤثر على ال morphology الخاص
+
+260
+00:17:59,610 --> 00:18:04,870
+بالـ spermatozoa، كل هذه المصطلحات وكل هذه الأسباب
+
+261
+00:18:04,870 --> 00:18:09,990
+تؤدي إلى حدوث مشاكل في عملية إنتاج أو تطور أو نضوج
+
+262
+00:18:09,990 --> 00:18:14,730
+الـ spermatozoa، مصطلح آخر بنسميه polyzoospermia،
+
+263
+00:18:14,730 --> 00:18:20,710
+polyzoospermia وهو عبارة عن مصطلح المقصود فيه زيادة
+
+264
+00:18:20,710 --> 00:18:25,490
+عدد الحيوانات المنوية في السائل لتصل إلى أكثر من
+
+265
+00:18:25,490 --> 00:18:29,850
+200 مليون خلية أو 200 مليون sperm per milliliter،
+
+266
+00:18:29,850 --> 00:18:34,450
+increase in the total number of spermatozoa to
+
+267
+00:18:34,450 --> 00:18:39,550
+arrive 200 million per milliliter، طبعا هذا العدد
+
+268
+00:18:39,550 --> 00:18:43,670
+مهول يعتبر، ومش كل زيادة في العدد تعتبر زيادة
+
+269
+00:18:43,670 --> 00:18:48,170
+إيجابية، فبالتالي الزيادة قد تكون سلبية، ببساطة جدًا،
+
+270
+00:18:48,170 --> 00:18:51,870
+تصور أن أنت عندك كمية كبيرة جدًا قد كل المدرسة أو
+
+271
+00:18:51,870 --> 00:18:56,130
+كل الجامعة في حالة من حالات التصقيد، سوف تخرج من
+
+272
+00:18:56,130 --> 00:19:00,730
+بوابة صغيرة جدًا، سوف يحدث تدافع عند عملية الخروج
+
+273
+00:19:00,730 --> 00:19:05,970
+مما يؤدي إلى وجود إصابات وقد يؤدي إلى اختناقات على
+
+274
+00:19:05,970 --> 00:19:10,640
+صعيد بسيط جدًا، على الوضع الحالي، فمباناك لو كان عندك
+
+275
+00:19:10,640 --> 00:19:17,340
+200 مليون sperm هيخرجوه بشكل دفقات متتالية، هيصير
+
+276
+00:19:17,340 --> 00:19:21,240
+في عندي نوع من أنواع إعاقة في الحركة، إعاقة في
+
+277
+00:19:21,240 --> 00:19:26,340
+الحركة، يعني تدمير، يعني ال fertility chance تقل و
+
+278
+00:19:26,340 --> 00:19:30,420
+تحدجيه عند المال، طبعًا it is usually associated with
+
+279
+00:19:30,420 --> 00:19:33,940
+a decrease in the volume of ejaculatory matter، هذا
+
+280
+00:19:33,940 --> 00:19:37,390
+السبب اللي بيؤدي إلى زيادة الحجز، زيادة العدد، إن ال 
+
+281
+00:19:37,390 --> 00:19:40,210
+حجم بدل ما يكون خمسة فيهم 200 مليون كان فيها
+
+282
+00:19:40,210 --> 00:19:45,090
+واحد مل فيهم 200 مليون فمن أهم أسباب زيادة ال
+
+283
+00:19:45,090 --> 00:19:49,330
+concentration of sperm أو دعنا نسميها زيادة ال
+
+284
+00:19:49,330 --> 00:19:52,330
+count of sperm هو عبارة عن حدوث reduction في ال
+
+285
+00:19:52,330 --> 00:19:55,730
+sperm volume في ال seminal volume it may be a
+
+286
+00:19:55,730 --> 00:19:59,610
+cause of infertility since such high concentration
+
+287
+00:19:59,610 --> 00:20:03,250
+can be difficult for their movement طبعا زيادة في
+
+288
+00:20:03,250 --> 00:20:08,670
+العدد يؤدي إلى تزاحم أثناء المسير في رحلة ال
+
+289
+00:20:08,670 --> 00:20:13,450
+fertilization فالتزاحم هذا هيكون تزاحم عكسي فهيمنع
+
+290
+00:20:13,450 --> 00:20:17,030
+من حركة ال sperm ما تزيد بشكل المطلوب و بشكل
+
+291
+00:20:17,030 --> 00:20:22,970
+المناسب لأن فيه تدافع طبعا it is important
+
+292
+00:20:22,970 --> 00:20:26,710
+condition in male fertility because white cell
+
+293
+00:20:26,710 --> 00:20:30,790
+are weak in the sperm and can't damage its genetic
+
+294
+00:20:30,790 --> 00:20:38,690
+material طبعا أيضا من أهم المصطلحات وجود بعض ال
+
+295
+00:20:38,690 --> 00:20:43,790
+white cells تؤثر سلبًا على هذه العملية طبعًا وجود
+
+296
+00:20:43,790 --> 00:20:47,970
+ال white cells لها علاقة بحاجة بتسميها
+
+297
+00:20:47,970 --> 00:20:52,250
+Pyospermia أو حاجة بتسميها presence of leukocyte
+
+298
+00:20:52,250 --> 00:20:56,230
+in seminal fluid طبعًا وجود ال leukocyte في ال
+
+299
+00:20:56,230 --> 00:21:00,190
+seminal fluid معناه أنه في عندي infection ال
+
+300
+00:21:00,190 --> 00:21:03,230
+infection هيهاجر كمية كبيرة جدًا من ال white
+
+301
+00:21:03,230 --> 00:21:05,470
+cells إلى المكان فبالتالي هيعملها destruction
+
+302
+00:21:06,450 --> 00:21:10,990
+ببساطة جدا وجود ال white cells هيعمل ROS 
+
+303
+00:21:10,990 --> 00:21:15,870
+هيعمل destruction ل genetic material فيؤدي إلى فشل
+
+304
+00:21:15,870 --> 00:21:21,870
+ال sperm في قدرته على عملية الإخصاب while the
+
+305
+00:21:21,870 --> 00:21:24,170
+blood cells release powerful substances called
+
+306
+00:21:24,170 --> 00:21:27,430
+reactive oxygen species which destroy organisms
+
+307
+00:21:27,430 --> 00:21:32,650
+that cause infection unfortunately أو للأسف بشكل
+
+308
+00:21:32,650 --> 00:21:38,540
+كبير جدا وجدوا أن الـ ROS بتأثر سلبًا بشكل كبير جدًا
+
+309
+00:21:38,540 --> 00:21:42,260
+على الـ sperm DNA على الـ sperm motility وعلى الـ
+
+310
+00:21:42,260 --> 00:21:45,280
+sperm movement طبعا فادوا بالكواخر تلت نقاط اللي
+
+311
+00:21:45,280 --> 00:21:49,540
+لهم علاقة بمصطلح وجود حاجة بنتسميها leukospermia
+
+312
+00:21:49,540 --> 00:21:53,260
+و leukospermia بيسموها وجود ال leukocyte بكميات
+
+313
+00:21:53,260 --> 00:21:57,740
+كبيرة جدًا في ال seminal fluid هذه رقم ثلاثة
+
+314
+00:21:57,740 --> 00:22:01,560
+النقطة رقم ثلاثة ونقطة رقم أربعة ونقطة رقم خمسة
+
+315
+00:22:01,560 --> 00:22:05,140
+لها علاقة بمصطلح اسمه leukospermia أو Pyospermia
+
+316
+00:22:05,660 --> 00:22:08,740
+و هذا المصطلح Leukospermia أو Pyospermia هي عبارة
+
+317
+00:22:08,740 --> 00:22:12,240
+عن presence of leukocyte in seminal fluid with high
+
+318
+00:22:12,240 --> 00:22:19,120
+number طبعا هذه المفروض في هنا عنوان جديد خلصنا من
+
+319
+00:22:19,120 --> 00:22:23,120
+المصطلحات التطبيقية المهمة سننتقل إلى موضوع جديد
+
+320
+00:22:23,120 --> 00:22:28,780
+كيف يتم تحضير عينات السائل من أجل ال ART أو ال IVF
+
+321
+00:22:28,780 --> 00:22:36,070
+أحد تقنيات ال ART طبعا في البداية في عندي مصطلح ال
+
+322
+00:22:36,070 --> 00:22:39,630
+IVF In Vitro Fertilization فيها عندي مصطلح الـ ICSI
+
+323
+00:22:39,630 --> 00:22:43,550
+وفيها عندي مصطلح ال IUI إيش يعني ال IUI اختصارها
+
+324
+00:22:43,550 --> 00:22:49,650
+Intrauterine Insemination وهي ببساطة جدا هي إيصال
+
+325
+00:22:49,650 --> 00:22:56,510
+لـ spermatozoa الناضجة إلى الرحم
+
+326
+00:22:56,510 --> 00:23:03,930
+متى بنستخدمها إذا كان في مواجهة عنيفة من قبل ال
+
+327
+00:23:03,930 --> 00:23:06,970
+female barriers الموجودة في منطقة الـ cervix ومنطقة
+
+328
+00:23:06,970 --> 00:23:11,130
+ال vagina لل spermatozoa أو ال spermatozoa لا تقدر
+
+329
+00:23:11,130 --> 00:23:15,010
+تقطع هذه المسافة فبيجي الطبيب بياخد ال spermatozoa
+
+330
+00:23:15,010 --> 00:23:17,550
+بيعملها preparation بيحطها في أنبوبة اسمها
+
+331
+00:23:17,550 --> 00:23:21,270
+catheter tube very thin و بيحطّنها داخل ال vagina
+
+332
+00:23:21,270 --> 00:23:24,890
+الخاصة بال female أو ببعناء آخر داخل الرحم الخاص
+
+333
+00:23:24,890 --> 00:23:28,690
+بال female مرورًا بال vagina و ال cervical فبيقصر
+
+334
+00:23:28,690 --> 00:23:33,240
+المسافة اللي هتمشيها ال spermatozoa و بيقصروبيقلل
+
+335
+00:23:33,240 --> 00:23:35,980
+معدل الأخطار اللي بتوجهها ال spermatozoa هذا
+
+336
+00:23:35,980 --> 00:23:41,100
+المصطلح بنسميه IUI intrauterine insemination يعني
+
+337
+00:23:41,100 --> 00:23:45,780
+الحقن داخل الرحم طبعا هذه بنعملها إذا كان ال female
+
+338
+00:23:45,780 --> 00:23:49,580
+طبيعية 100% ولكن في عندي مشكلة في ال motility
+
+339
+00:23:49,580 --> 00:23:56,360
+الخاصة بال male spermatozoa شو السبب منها؟ شو
+
+340
+00:23:56,360 --> 00:24:00,700
+الهدف منها؟ تقليل المصاعب والمخاطر اللي يتواجهها
+
+341
+00:24:00,700 --> 00:24:05,340
+الـ spermatozoa خلال رحلة ال fertilization في
+
+342
+00:24:05,340 --> 00:24:08,700
+منطقة ال cervical أو منطقة ال vagina مرتبطة على ال
+
+343
+00:24:08,700 --> 00:24:14,920
+leukocyte و الـ antisperm antibody و خلافه طيب ال
+
+344
+00:24:14,920 --> 00:24:20,440
+sperm process for IVF كيف يتم تحضير العينة؟ أو
+
+345
+00:24:20,440 --> 00:24:24,210
+خلال عملية تحضير العينة، شو بيصير؟ طبعا خلال .. أو
+
+346
+00:24:24,210 --> 00:24:27,250
+فكرة تحضير العينة و الفكرة الأساسية لتحضير العينة
+
+347
+00:24:27,250 --> 00:24:31,010
+ومبدأ تحضير العينة يقوم على مبدأ أساسي هو عزل
+
+348
+00:24:31,010 --> 00:24:35,370
+الحيوانات المنوية الجيدة التي تعتبر normal form و
+
+349
+00:24:35,370 --> 00:24:38,690
+good motile فبالتالي طالما في عندي عزل للحيوانات
+
+350
+00:24:38,690 --> 00:24:42,130
+المنوية الجيدة إذا سوف يتم التخلص من ال seminal
+
+351
+00:24:42,130 --> 00:24:47,830
+fluid أو ال seminal plasma يتم التخلص من خلالها من
+
+352
+00:24:47,830 --> 00:24:50,790
+العوامل التي تعمل decapacitation والمقصود بال
+
+353
+00:24:50,790 --> 00:24:53,880
+decapacitation يعني فقدان الحيوانة المنوية القدرة
+
+354
+00:24:53,880 --> 00:24:59,920
+على الإخصاب إبعاد وعزل الـ dysfunctional و الـ ROS
+
+355
+00:24:59,920 --> 00:25:05,680
+producing sperm بمعنى آخر إبعاد الـ sperm ب
+
+356
+00:25:05,680 --> 00:25:09,340
+dysfunction اللي ممكن يفرز كمية كبيرة جدا من الـ ROS
+
+357
+00:25:09,340 --> 00:25:13,460
+اللي بتدمر الحيوانات المنوية الأخرى التخلص من ال
+
+358
+00:25:13,460 --> 00:25:16,980
+leukocyte لأن ال leukocyte جالب شوية حكينا ممكن
+
+359
+00:25:16,980 --> 00:25:22,580
+يفرز كمية كبيرة جدا من ال ROS التخلص من البكتيريا من
+
+360
+00:25:22,580 --> 00:25:26,720
+أن البكتيريا تلعب سلبًا ودورًا سلبيًا على
+
+361
+00:25:26,720 --> 00:25:31,940
+الحيوانات المنوية المتبقية وتحسين قدرة الـ sperm
+
+362
+00:25:31,940 --> 00:25:36,000
+من حيث الحركة والمحافظة على المادة الوراثية بالشكل
+
+363
+00:25:36,000 --> 00:25:39,040
+الكامل بالإضافة إلى المحافظة على الـ Acrosome
+
+364
+00:25:39,040 --> 00:25:41,780
+Reaction والمحافظة على الـ sperm في حالة Normal
+
+365
+00:25:41,780 --> 00:25:47,580
+Form إذن هذه الخمس نقاط، خمس نقاط أساسية تحدث خلال
+
+366
+00:25:47,580 --> 00:25:51,720
+عملية الـ Sperm Processing for IVF من أجلها
+
+367
+00:25:51,920 --> 00:25:54,900
+يتم المحافظة على الـ sperm يتم المحافظة على الـ
+
+368
+00:25:54,900 --> 00:25:57,780
+sperm و الـ acrosome ... sperm morphology و الـ
+
+369
+00:25:57,780 --> 00:26:01,580
+acrosome reaction و الـ motility الخاصة بالـ sperm
+
+370
+00:26:01,580 --> 00:26:05,580
+كيف يتم المحافظة على هذه الأمور؟ من خلال التخلص من
+
+371
+00:26:05,580 --> 00:26:08,520
+الحيوانات المنوية الميتة التخلص من البكتيريا
+
+372
+00:26:08,520 --> 00:26:12,100
+التخلص من الكرات الدم البيضاء و التخلص من ال
+
+373
+00:26:12,100 --> 00:26:15,600
+seminal plasma التي قد تحتوي على الـ anti sperm
+
+374
+00:26:15,600 --> 00:26:20,200
+antibody أو إذا كان طبعًا لل male يصنع antibody ضد
+
+375
+00:26:20,200 --> 00:26:25,070
+نفسه أو يحتوي على الـ Decapitation Factor هذه أهم
+
+376
+00:26:25,070 --> 00:26:30,750
+خمس نقاط أساسية أهم خمس نقاط أساسية ما هي الطرق
+
+377
+00:26:30,750 --> 00:26:34,130
+التي تستخدم في عملية ال isolation أول طريقة تستخدم
+
+378
+00:26:34,130 --> 00:26:36,750
+في عملية ال isolation و ال extraction و ال
+
+379
+00:26:36,750 --> 00:26:41,770
+processing هي طريقة بسيطة جدا تسمى simple dilution
+
+380
+00:26:41,770 --> 00:26:45,190
+and washing simple dilution and washing هنتكلم
+
+381
+00:26:45,190 --> 00:26:48,490
+عنها بالتفصيل النقطة الثانية أو الطريقة الثانية هي
+
+382
+00:26:48,490 --> 00:26:53,710
+ال sperm up و من اسمها سباحة للأعلى النقطة الثالثة
+
+383
+00:26:53,710 --> 00:26:57,510
+و الطريقة الثالثة هي density أو density gradient
+
+384
+00:26:57,510 --> 00:27:01,510
+centrifugation density gradient gradient
+
+385
+00:27:01,510 --> 00:27:06,870
+centrifugation بمعنى آخر الفصل بناء على الكثافة
+
+386
+00:27:06,870 --> 00:27:11,270
+المتدرجة في عندي simple dilution and washing في
+
+387
+00:27:11,270 --> 00:27:14,650
+عندي sperm swim up في عندي density gradient
+
+388
+00:27:14,650 --> 00:27:18,420
+centrifugation طبعا هذه الثلاث نقاط أو الثلاث عوامل
+
+389
+00:27:18,420 --> 00:27:22,960
+أو الثلاث طرق إن صح التعبير الأكثر استخداما والأكثر
+
+390
+00:27:22,960 --> 00:27:27,080
+شيوعا ولكن حاليا الأكثر استخداما الطريقة الثانية
+
+391
+00:27:27,080 --> 00:27:30,960
+أو الثالثة والأكثر على الإطلاق والأكثر استخداما في
+
+392
+00:27:30,960 --> 00:27:34,060
+مختبرات ال IVF هي الطريقة الثالثة اللي لها علاقة
+
+393
+00:27:34,060 --> 00:27:37,700
+بال density خلينا نأخذ الطريقة الأولى اللي اسمها
+
+394
+00:27:37,700 --> 00:27:42,010
+simple dilution and washing ببساطة جدًا خلال هذه
+
+395
+00:27:42,010 --> 00:27:45,550
+العملية يتم فصل ال spermatozoa عن ال seminal
+
+396
+00:27:45,550 --> 00:27:49,810
+fluid بما يحتويه فصل ال spermatozoa عن ال seminal
+
+397
+00:27:49,810 --> 00:27:55,130
+fluid بما يحتويه هذا الإجراء يحفظ قدرة الإجراء
+
+398
+00:27:55,130 --> 00:27:58,910
+للتواصل بشكل كبير بما يحتوي عليه الإجراء بما يحتوي
+
+399
+00:27:58,910 --> 00:28:01,110
+عليه الإجراء بما يحتوي عليه الإجراء بما يحتوي على
+
+400
+00:28:01,110 --> 00:28:02,530
+الإجراء بما يحتوي عليه الإجراء بما يحتوي على
+
+401
+00:28:02,530 --> 00:28:05,310
+الإجراء بما يحتوي عليه الإجراء بما يحتوي على
+
+402
+00:28:05,310 --> 00:28:06,170
+الإجراء بما يحتوي عليه الإجراء بما يحتوي على
+
+403
+00:28:06,170 --> 00:28:08,210
+الإجراء بما يحتوي عليه الإجراء بما يحتوي على
+
+404
+00:28:08,210 --> 00:28:11,770
+الإجراء بما يحتوي عليه هذه الطريقة الأولى، يعني
+
+405
+00:28:11,770 --> 00:28:16,430
+أكثر ... أو أكثر الحالات التي يستخدم معها الطريقة
+
+406
+00:28:16,430 --> 00:28:19,050
+الأولى ال simple dilution and washing مثل ... إذا
+
+407
+00:28:19,050 --> 00:28:23,570
+كان في عندي immune disorder إذا كان في عندي male
+
+408
+00:28:23,570 --> 00:28:30,590
+factor أو حالات عدم إنجاب غير معروفة السبب طبعا
+
+409
+00:28:30,590 --> 00:28:33,070
+هذا ال ... هذا ال technique بيحتاج dilution و
+
+410
+00:28:33,070 --> 00:28:37,270
+centrifugation طبعا ال sperm بيصير له washing ب
+
+411
+00:28:37,270 --> 00:28:40,370
+solution يحتوي على ال antibiotic و بعض ال
+
+412
+00:28:40,370 --> 00:28:44,390
+supplemental protein ومن أشهرهم الـ albumin يُضاف
+
+413
+00:28:44,390 --> 00:28:47,530
+يعني كإن أنا بستخدم media هذه ال media فيها
+
+414
+00:28:47,530 --> 00:28:52,210
+antibiotic plus supplemental protein like albumin
+
+415
+00:28:52,210 --> 00:28:56,890
+بضيفها على عينة السمن بمعدل 1 إلى 1، 2 إلى 2
+
+416
+00:28:56,890 --> 00:29:00,350
+و خلافه ولكن الأكثر استخدام من ال ratio one to one
+
+417
+00:29:00,350 --> 00:29:05,590
+ال media sterile of the equal volume from the
+
+418
+00:29:05,590 --> 00:29:07,970
+seminal fluid يعني ال ratio ما بين ال media
+
+419
+00:29:07,970 --> 00:29:10,930
+المستخدمة التي تحتوي على الـ supplemental protein و
+
+420
+00:29:10,930 --> 00:29:15,330
+الـ antibiotic إلى كمية السمن fluid لازم تكون 1 
+
+421
+00:29:15,330 --> 00:29:19,690
+لـ 1 مل بمعنى أنا أضفت أو بدي أعمل Washing لـ 1 مل من
+
+422
+00:29:19,690 --> 00:29:23,590
+العينة بدي أضيف 1 مل من الـ Sample فبالتالي بعمل
+
+423
+00:29:23,590 --> 00:29:26,770
+Mixing للعينة و بقيس كده عندي الـ volume تدريجيًا
+
+424
+00:29:26,770 --> 00:29:30,400
+عندي 5 مل إذا لازم أضيف عليهم خمسة مل من الـ media
+
+425
+00:29:30,400 --> 00:29:34,220
+بعملها good mixing بعدين بضيفها في test tube و
+
+426
+00:29:34,220 --> 00:29:38,140
+بعملها centrifugation باستخدام طبعًا الـ
+
+427
+00:29:38,140 --> 00:29:42,300
+centrifuge طبعًا الـ centrifugation لها زمن معين و
+
+428
+00:29:42,300 --> 00:29:46,760
+سرعة معينة فبعملها centrifugation على ثلاثمية دورة
+
+429
+00:29:46,760 --> 00:29:52,840
+300 G لمدة عشر دقائق فهتفصل لنا مركبين أو طبقتين الـ
+
+430
+00:29:52,840 --> 00:29:55,560
+semen في الأسفل و الـ supernatant كلها في الأعلى
+
+431
+00:29:56,430 --> 00:30:00,630
+removing with sterile pipet طبعًا هنا for 10 minutes
+
+432
+00:30:00,630 --> 00:30:04,310
+and then the supernatant is very careful remove
+
+433
+00:30:04,310 --> 00:30:08,630
+طبعًا الـ supernatant أنا ما بدي إياه لإنه فيه كل الـ
+
+434
+00:30:08,630 --> 00:30:12,410
+debris فيه كل الـ decomposition factor فيه كل
+
+435
+00:30:12,410 --> 00:30:17,010
+العوامل اللي ممكن تؤثر سلبًا على الـ sperm فبعمل
+
+436
+00:30:17,010 --> 00:30:21,530
+removing للـ supernatant بسحبه بالـ sterile pipet أو
+
+437
+00:30:21,530 --> 00:30:25,030
+الـ dropper و برميه لـ Palette أو لـ Sediment
+
+438
+00:30:25,030 --> 00:30:28,230
+الموجود بعملها Resuspension و بضيف عليها بعد كده
+
+439
+00:30:28,230 --> 00:30:31,610
+واحد مل من نفس الـ media و بعملها Mixing و
+
+440
+00:30:31,610 --> 00:30:35,810
+Centrifugation لمدة خمس دقائق على نفس السرعة 300 G
+
+441
+00:30:35,810 --> 00:30:39,110
+برفع الـ supernatant و برميه بتخلص منه و بعمله
+
+442
+00:30:39,110 --> 00:30:42,910
+discard بعد كده بعمل Resuspension للـ Pellet و
+
+443
+00:30:42,910 --> 00:30:46,010
+بضيف عليها واحد مل من نفس الـ media أنا كده بكون
+
+444
+00:30:46,010 --> 00:30:49,410
+غسلتها مرتين ممكن أغسلها كمان مرة ما فيش مشكلة بضيف
+
+445
+00:30:49,410 --> 00:30:53,140
+واحد مل مرة ثانية Mixing centrifugation على 300 G
+
+446
+00:30:53,140 --> 00:30:57,580
+لمدة خمس دقائق بتخلص من الـ super net and بضيف أو 
+
+447
+00:30:57,580 --> 00:31:01,780
+بعمل resuspension للـ sediment الموجود أو للـ Pellet 
+
+448
+00:31:01,780 --> 00:31:09,060
+الموجود طبعًا كده الـ sediment بتكون جاهزة لعملية الـ
+
+449
+00:31:09,060 --> 00:31:13,360
+IUI for example جاهزة لعملية الـ IVF for example
+
+450
+00:31:13,360 --> 00:31:16,620
+بناءً على طبيعة العينة أو طبيعة الـ process اللي أنا
+
+451
+00:31:16,620 --> 00:31:19,990
+بدي أستخدمه طبعًا استخدمت عشر دقائق و بعدين عشر
+
+452
+00:31:19,990 --> 00:31:22,630
+دقائق و بعدين عشر دقائق يعني ممكن تأخذ لـ minimum
+
+453
+00:31:22,630 --> 00:31:27,110
+ثلاثين دقيقة العملية ككل ما بين عملية الـ first
+
+454
+00:31:27,110 --> 00:31:33,150
+centrifugation حتى الـ last time أو الـ last step
+
+455
+00:31:33,150 --> 00:31:37,630
+centrifugation طبعًا مهم جدًا قبل ما أكون جهزت
+
+456
+00:31:37,630 --> 00:31:43,090
+العينة و بعدها لـ empirical lab أو لعملية الحقن
+
+457
+00:31:43,090 --> 00:31:47,420
+بشكل أساسي لازم أعمل evaluation للعينة أو للـ Pellet أو
+
+458
+00:31:47,420 --> 00:31:50,560
+للـ semen إن أشوف ما فيش فيه متايل sperm ما فيش
+
+459
+00:31:50,560 --> 00:31:54,420
+فيه count sperm بعد كده أعملها preparation
+
+460
+00:31:54,420 --> 00:31:58,480
+preparing for insemination insemination يعني الحقن
+
+461
+00:31:58,480 --> 00:32:02,900
+الـ Insemination أي ما المقصود فيه برجع بأكد أن هذه العملية بتأخذ
+
+462
+00:32:02,900 --> 00:32:06,680
+لها كمية قليلة جدًا من الوقت يعني ثلاثين الـ أربعين
+
+463
+00:32:06,680 --> 00:32:10,960
+دقيقة يعني مش الوقت الكبير المرحلة الثانية من
+
+464
+00:32:10,960 --> 00:32:13,720
+المرحلة التي تستخدم أو الطريقة الثانية طريقة الـ
+
+465
+00:32:13,720 --> 00:32:16,400
+Swim-up طبعًا طريقة this warm-up هي أكثر الطرق
+
+466
+00:32:16,400 --> 00:32:18,660
+التي يتم فيها استخدامها في الـ research على سبيل
+
+467
+00:32:18,660 --> 00:32:22,500
+المثال و الـ I.O.I. الـ research و الـ I.O.I. طبعًا
+
+468
+00:32:22,500 --> 00:32:25,240
+في هذه العملية أو عملية this warm-up الـ principle
+
+469
+00:32:25,240 --> 00:32:29,140
+الأساسي الخاص فيها أنه فقط الـ spermatozoa التي
+
+470
+00:32:29,140 --> 00:32:32,940
+تُعتبر  progressive motility أو progressive motile .. progressive motile
+
+471
+00:32:32,940 --> 00:32:36,880
+spermatozoa هي التي تستطيع السباحة للأعلى يعني هنا
+
+472
+00:32:36,880 --> 00:32:41,180
+بفصل فقط الـ motile sperm عن باقي الـ spermatozoa عن
+
+473
+00:32:41,180 --> 00:32:45,170
+باقي الـ debris عن باقي الأمور التي لا نريد أن
+
+474
+00:32:45,170 --> 00:32:50,450
+تتواجد مع العينة ليه؟ لأن ببساطة جدًا الحيوانات
+
+475
+00:32:50,450 --> 00:32:54,750
+المنوية الأكثر صحة الأكثر قدرة على الحركة التي
+
+476
+00:32:54,750 --> 00:32:57,950
+تُعتبر حركتها طبيعية هي التي تستطيع أن تسبح للأعلى
+
+477
+00:32:57,950 --> 00:33:03,170
+طيب ليه تسبح للأعلى؟ هنعرف ليه سميت أصلاً Swim-up طبعًا
+
+478
+00:33:03,170 --> 00:33:06,130
+this procedure is very easy to perform and allowed
+
+479
+00:33:06,130 --> 00:33:07,970
+recovery for good number of progressive
+
+480
+00:33:07,970 --> 00:33:14,430
+spermatozoa في مجموعة Normal Spermatozoa أو مجموعة
+
+481
+00:33:14,430 --> 00:33:22,490
+Normal Sperm طبعًا في البداية هذه الطريقة لديها
+
+482
+00:33:22,490 --> 00:33:25,530
+عديد من المفاتيح منها على سبيل المثال إنه بيعمل
+
+483
+00:33:25,530 --> 00:33:27,870
+reduction في percentage of normal chromatin
+
+484
+00:33:27,870 --> 00:33:31,610
+condensation in spermatozoa بيعمل why pellets
+
+485
+00:33:31,610 --> 00:33:35,330
+spermatozoa are in close contact with other cell
+
+486
+00:33:35,330 --> 00:33:38,450
+debris leucocytes at the bottom of the tube
+
+487
+00:33:38,620 --> 00:33:42,460
+beginning exposure to the high level of ROS طبعًا
+
+488
+00:33:42,460 --> 00:33:46,880
+طالما فقط الـ spermatozoa التي تتميز بالـ progressive motility
+
+489
+00:33:46,880 --> 00:33:50,580
+التي تسبح في الأعلى إذا أنا هفقد كمية كبيرة جدًا من
+
+490
+00:33:50,580 --> 00:33:54,360
+الـ spermatozoa في الـ centrifugation و هتقل في
+
+491
+00:33:54,360 --> 00:33:58,260
+الـ Pellet وجودها في الـ Pellet يعني قريبة من الـ leukocyte
+
+492
+00:33:58,260 --> 00:34:01,640
+قريبة من الـ leukocyte يعني قريبة من الـ ROS قريبة
+
+493
+00:34:01,640 --> 00:34:05,500
+من الـ ROS يعني عندي الـ ROS هتأثر على الـ spermatozoa و
+
+494
+00:34:05,500 --> 00:34:08,970
+هيعمل لي destructure لها عشان كده بلاقي عدد
+
+495
+00:34:08,970 --> 00:34:13,890
+الحيوانات المنوية التي تسبح للأعلى قليل جدًا قد
+
+496
+00:34:13,890 --> 00:34:17,370
+تكون Normal Motile ولكن قد لا تكون Normal
+
+497
+00:34:17,370 --> 00:34:20,570
+Morphology أو Normal Sperm Condensation المادة
+
+498
+00:34:20,570 --> 00:34:24,390
+الوراثية مش هتكون .. ممكن ما تكونش Normal بنسبة
+
+499
+00:34:24,390 --> 00:34:29,410
+100% فبالتالي هذه تُعتبر من الطرق التي تُستخدم
+
+500
+00:34:29,410 --> 00:34:33,870
+طبعًا أكثر استخدام لهذه الطريقة في عملية الـ I.O.I
+
+501
+00:34:33,870 --> 00:34:38,880
+بسميها Intra-Uterine Insemination كيف أنا هتشتغل
+
+502
+00:34:38,880 --> 00:34:42,940
+هذه الطريقة و كيف بتتم ببساطة جدًا بجيب عينة الـ
+
+503
+00:34:42,940 --> 00:34:47,660
+seminal fluid بعمل Mixing بينها و بين الـ media
+
+504
+00:34:47,660 --> 00:34:52,880
+اسمها IOI media بنسبة 1 إلى 2 شو يعني 1 إلى 2؟
+
+505
+00:34:52,880 --> 00:34:58,280
+بمعنى آخر أنا عندي 1 مل Semen بضيف عليها 2 مل Washing
+
+506
+00:34:58,280 --> 00:35:03,200
+culture media أو IOI media أو بسموها Washing media
+
+507
+00:35:04,630 --> 00:35:08,670
+أو Swim-up media اللي هي مسميات كثيرة عندي 1 مل
+
+508
+00:35:08,670 --> 00:35:12,530
+بضيف عليها 2 مل من الـ media بعمل Mixing طبعًا هذا
+
+509
+00:35:12,530 --> 00:35:15,450
+في الـ sterilized tube و بعمله Centrifugation لمدة
+
+510
+00:35:15,450 --> 00:35:22,230
+10 دقائق على 2200 rpm بعد كده بتخلص من كل الـ
+
+511
+00:35:22,230 --> 00:35:25,090
+supernatant ما ليش علاقة بيه بعمله discard و بعدين
+
+512
+00:35:25,090 --> 00:35:31,030
+بعدين بضيف عليه نفس الـ media بكمية معينة 1 مل 1.5
+
+513
+00:35:31,030 --> 00:35:35,430
+مل بناءً على كمية الـ Pellet الموجودة ولكن عملية إضافة الـ
+
+514
+00:35:35,430 --> 00:35:38,950
+media هنا بتتم بشكل Slowly جدًا وعلى الجدار
+
+515
+00:35:38,950 --> 00:35:42,090
+الداخلي للأنبوبة يعني بأخذ بالـ  sterile و أضربها 1
+
+516
+00:35:42,090 --> 00:35:47,410
+مل أو 2 مل بأنها ما فيش عندي حجم الـ Pellet عندي
+
+517
+00:35:47,410 --> 00:35:50,370
+حجم الـ Pellet أو الـ sediment 1 مل بأخذ 2 مل و
+
+518
+00:35:50,370 --> 00:35:54,650
+بميل الأنبوبة و بنزل السائل أو الـ solution أو الـ
+
+519
+00:35:54,650 --> 00:35:58,510
+media على الجدار الداخلي للأنبوبة عشان ما يصيرش drop
+
+520
+00:35:58,510 --> 00:36:05,160
+مرة واحدة مع الـ sediment بعد كده بأخذ الأنبوبة هذه
+
+521
+00:36:05,160 --> 00:36:11,460
+و بضيفها بشكل مائل بزاوية 45 درجة و بحطها في الـ
+
+522
+00:36:11,460 --> 00:36:17,540
+incubator لمدة 45 دقيقة على 37 درجة مئوية طبعًا
+
+523
+00:36:17,540 --> 00:36:23,540
+هذه الـ Inclination أو بزاوية 45 بالـdenis landship بتساعد
+
+524
+00:36:23,540 --> 00:36:28,840
+الـ spermatozoa أنها تسبح بسهولة نحو السطح فبالتالي
+
+525
+00:36:28,840 --> 00:36:32,900
+ما بيكون فيش قوة كبيرة جدًا بتواجد الـ spermatozoa
+
+526
+00:36:32,900 --> 00:36:36,140
+تقاوم عملية السباحة للأعلى بالفعل الـ gravity فأنا
+
+527
+00:36:36,140 --> 00:36:39,140
+عملت عملية Inclination لها عشان أُقلل المسافة اللي
+
+528
+00:36:39,140 --> 00:36:42,340
+هتقطعها الـ spermatozoa و ما أُجهد الـ sperm لأن أنا
+
+529
+00:36:42,340 --> 00:36:46,360
+محتاج حركته في عملية الـ fertilization بعد ما أخلص
+
+530
+00:36:46,360 --> 00:36:53,200
+الـ 40 أو الـ 45 دقيقة بأجي بطلع الأنبوبة برفعها
+
+531
+00:36:53,200 --> 00:36:56,840
+بأجي أشوف الـ supernatant بعد ما كانت clear صارت turbid معناه
+
+532
+00:36:56,840 --> 00:37:00,900
+فيه spermatozoa صعدت للأعلى بأخذ كل الـ supernatant
+
+533
+00:37:00,900 --> 00:37:03,780
+اللي فيه spermatozoon و بضيفه في الـ sterile test
+
+534
+00:37:03,780 --> 00:37:08,160
+tube و بعمل evaluation للعينة من حيث الـ count و من
+
+535
+00:37:08,160 --> 00:37:11,700
+حيث الـ motility قد ايش فيها Sperm و قد ايش فيها
+
+536
+00:37:11,700 --> 00:37:15,470
+متغير الـ Sperm طبعًا هذه صورة بتوضح الكلام فيها
+
+537
+00:37:15,470 --> 00:37:18,490
+عندي Test tube ضفت العينة واحد منه وضفت عليها
+
+538
+00:37:18,490 --> 00:37:21,890
+اثنين من الـ media عملتلها Mixing ثم تخلصت
+
+539
+00:37:21,890 --> 00:37:26,450
+بـ centrifugation وتخلصت من الـ supernatant ضفت media أخرى
+
+540
+00:37:26,450 --> 00:37:30,590
+تتناسب مع كمية الـ sediment الموجودة ضفتها وقمت
+
+541
+00:37:30,590 --> 00:37:34,250
+بوضعها في Rack بزاوية 45 درجة مئوية ودخلتها الـ
+
+542
+00:37:34,250 --> 00:37:38,910
+incubator على 37 درجة .. عفواً ضفتها في الـ Rack
+
+543
+00:37:38,910 --> 00:37:42,990
+بزاوية 45 درجة بعدين أدخلت الـ Rack بالأنبوبة داخل الـ
+
+544
+00:37:42,990 --> 00:37:48,850
+incubator على درجة حرارة 37 درجة مئوية لمدة من 20 لـ 40
+
+545
+00:37:48,850 --> 00:37:51,910
+دقيقة بعد كده هرفع الأنبوبة هلاقي الـ supernatant
+
+546
+00:37:51,910 --> 00:37:55,330
+turbid بعد ما كان clear دليل أنه في spermatozoon
+
+547
+00:37:55,640 --> 00:37:58,420
+بأخذ كل الـ supernatant اللي موجود بالأعلى دون
+
+548
+00:37:58,420 --> 00:38:02,040
+ما ألامس الـ sediment و بضيفها في أنبوبة جديدة بعدين
+
+549
+00:38:02,040 --> 00:38:05,380
+بأخذ منه عشرة micro بعمله assessment علشان أشوف كم
+
+550
+00:38:05,380 --> 00:38:09,080
+في عندي Sperm count و كم في عندي Motile و كم في
+
+551
+00:38:09,080 --> 00:38:13,500
+عندي عدد من حيث عدد الـ Sperm طبعًا هذه الطريقة
+
+552
+00:38:13,500 --> 00:38:18,080
+ما بتحتاج Skill معينة طريقة سهلة جدًا رخيصة جدًا
+
+553
+00:38:18,080 --> 00:38:23,120
+ما بتحتاج لـ Test tube و Media و أكثر استخدامها للـ IVF
+
+554
+00:38:23,120 --> 00:38:24,920
+التقليدي بالإضافة
+
+555
+00:38:30,570 --> 00:38:35,230
+الطريقة الثالثة التي تعتبر هي أكثر الطرق استخدامًا
+
+556
+00:38:35,230 --> 00:38:38,630
+طريقة الـ Density Gradient Centrifugation يعني
+
+557
+00:38:38,630 --> 00:38:43,050
+الـ فصل باستخدام الكثافة المختلفة أو طبقة الكثافة
+
+558
+00:38:43,050 --> 00:38:49,740
+المختلفة طبعًا هذه التقنية هي تقنية مهمة جدًا لاختيار
+
+559
+00:38:49,740 --> 00:38:53,640
+عدد كبير أو عدد كبير من Motile spermatozoa في حالة
+
+560
+00:38:53,640 --> 00:38:55,100
+عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد 
+
+561
+00:38:55,100 --> 00:38:55,920
+عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد
+
+562
+00:38:55,920 --> 00:38:57,260
+عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد
+
+563
+00:38:57,260 --> 00:38:57,980
+عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد
+
+564
+00:38:57,980 --> 00:39:08,900
+عدد عدد عدد عدد عدد عدد عدد عدد عدد
+
+565
+00:39:08,900 --> 00:39:09,520
+ع
+
+566
+00:39:14,210 --> 00:39:17,850
+العينات التي تُصنف على أنها Oligospermia أو
+
+567
+00:39:17,850 --> 00:39:23,070
+Teratospermia أو Asthenozoospermia طبعاً، in this
+
+568
+00:39:23,070 --> 00:39:25,890
+method, good quality sperm can be separated from
+
+569
+00:39:25,890 --> 00:39:29,270
+dead sperm أمر طبيعي، from leukocytes، from other
+
+570
+00:39:29,270 --> 00:39:32,490
+compounds of the seminal plasma by density
+
+571
+00:39:32,490 --> 00:39:35,770
+discontinuous gradient ما المقصود فيه؟ 
+
+572
+00:39:35,770 --> 00:39:39,090
+the density discontinuous gradient يعني كثافة متدرجة
+
+573
+00:39:39,090 --> 00:39:44,290
+غير متصلة من حيث الكثافة ما بقول كل أنبوبة 90%
+
+574
+00:39:44,290 --> 00:39:48,090
+كثافتها هنحكي عنها شيء عن كثافة متدرجة أو كثافة
+
+575
+00:39:48,090 --> 00:39:52,650
+غير متواصلة فكرتها أنه أنا بفصل الـ good sperm من
+
+576
+00:39:52,650 --> 00:39:56,430
+حيث الـ quality عن الـ other spermatozoa عن الـ bad
+
+577
+00:39:56,430 --> 00:39:59,270
+quality sperm عن الـ dead sperm عن الـ ecocide عن الـ
+
+578
+00:39:59,270 --> 00:40:02,210
+debris عن الـ other material فكيف أنا بدي أشتغلها
+
+579
+00:40:02,210 --> 00:40:06,450
+ببساطة جداً ببساطة جداً بجيب test tube بضيف فيها
+
+580
+00:40:06,450 --> 00:40:11,020
+عندي two types of media نفس الـ media ولكن with
+
+581
+00:40:11,020 --> 00:40:13,960
+different concentrations كدا بسميها two types of
+
+582
+00:40:13,960 --> 00:40:18,780
+media من حيث الـ density وليس من حيث النوع two
+
+583
+00:40:18,780 --> 00:40:23,320
+types of media according to density not according
+
+584
+00:40:23,320 --> 00:40:27,400
+to composition فنفرض إن الـ media الأولى تركيزها 40
+
+585
+00:40:27,400 --> 00:40:30,860
+و الـ media الأولى كثافتها 40 و الـ media الثانية
+
+586
+00:40:30,860 --> 00:40:38,080
+كثافتها 80 فبأخذ ببساطة جداً بجيب الـ test tube بضيف
+
+587
+00:40:38,080 --> 00:40:43,520
+عليها top layer 40% يعني بمعنى آخر بجيب الـ media
+
+588
+00:40:43,520 --> 00:40:47,680
+اللي كثافتها 80% وأضيف واحد منها بعدين كده بجيب الـ
+
+589
+00:40:47,680 --> 00:40:51,920
+media اللي كثافتها 40% وأضيف واحد منها آخر بشرط أن
+
+590
+00:40:51,920 --> 00:40:55,500
+الإضافة تكون بشكل مائل عشان ما يصير strong mix
+
+591
+00:40:55,500 --> 00:41:00,460
+between two types of media فهتكون الـ layer السفلى
+
+592
+00:41:00,460 --> 00:41:04,800
+لها علاقة بالـ media اللي كثافتها 80% بينما الـ
+
+593
+00:41:04,800 --> 00:41:08,720
+layer العلوية لها علاقة بالـ media اللي كثافتها 40%
+
+594
+00:41:09,440 --> 00:41:13,060
+بعدين بجيب 2 مل .. طبعاً خذوا بالكم النسبة لازم
+
+595
+00:41:13,060 --> 00:41:17,000
+تكون 1 إلى 1 حطيت 1 مل من الـ media الأولى هتكون 1 مل
+
+596
+00:41:17,000 --> 00:41:20,700
+من الـ media الثانية و 1 مل من الـ seminal fluid أو
+
+597
+00:41:20,700 --> 00:41:28,020
+العينة حطيت 2 مل 80% و 2 مل 40% بعدين ضفت العينة و
+
+598
+00:41:28,020 --> 00:41:33,270
+قلت هتكون 2 مل من عينة الـ semen ما بعمل mix؟ وعملية
+
+599
+00:41:33,270 --> 00:41:36,690
+الإضافة بتكون بشكل very slowly على الجدار الداخل
+
+600
+00:41:36,690 --> 00:41:40,350
+للأنبوبة عشان ما يصيرش mix بين الطبقات الداخلية من
+
+601
+00:41:40,350 --> 00:41:46,370
+الأسفل لأعلى media 80% و 20% و 40% ورقم 3 seminal
+
+602
+00:41:46,370 --> 00:41:51,410
+fluid بعمله centrifugation على 300xg لمدة 20 minute
+
+603
+00:41:51,410 --> 00:41:56,430
+بأطلع الأنبوبة بكل بساطة وبدون استعجال عشان
+
+604
+00:41:56,430 --> 00:42:01,720
+ما أعملش mix حلاجة في عندي انقسام separating من
+
+605
+00:42:01,720 --> 00:42:04,860
+الأعلى للأسفل سيكون في الأعلى الـ Seminal Fluid
+
+606
+00:42:04,860 --> 00:42:08,220
+يليه بالـ sperm, other debris, bacteria,
+
+607
+00:42:08,420 --> 00:42:11,960
+debris, immature, non mature, spermatozoa,
+
+608
+00:42:12,080 --> 00:42:16,160
+pellet, other target يعني سيكون عندي فقط طبقتين
+
+609
+00:42:16,160 --> 00:42:20,640
+الطبقة العلوية هي الـ Seminal Fluid بكل ما ذكرنا و
+
+610
+00:42:20,640 --> 00:42:23,260
+الطبقة السفلية هي الـ pellet اللي فيها الـ target
+
+611
+00:42:23,260 --> 00:42:27,140
+بأخذ
+
+612
+00:42:27,140 --> 00:42:31,930
+كل الطبقة العلوية بدون أعمل أي touch للـ pellet و
+
+613
+00:42:31,930 --> 00:42:36,730
+برميها بعملها discard we don't need it بعد كده
+
+614
+00:42:36,730 --> 00:42:41,530
+transfer the sperm pellet to the new tube and then
+
+615
+00:42:41,530 --> 00:42:45,210
+add 5ml of the sperm wash في ناس بتاخد الـ pellet
+
+616
+00:42:45,210 --> 00:42:49,410
+ل test tube جديدة وفي ناس أصلاً بتضيف على الـ pellet
+
+617
+00:42:49,410 --> 00:42:54,650
+مباشرة وبتعملها mixing من pure media و pure wash
+
+618
+00:42:54,650 --> 00:42:56,870
+media خمسة مل بضيفه على الـ pellet بعمله
+
+619
+00:42:56,870 --> 00:43:00,950
+resuspension centrifugation لمدة 10 دقائق على 500
+
+620
+00:43:00,950 --> 00:43:06,190
+XG بعمل remove all the sperm washing except
+
+621
+00:43:06,190 --> 00:43:09,730
+the last one ml بمعنى آخر بعد ما أضفت الخمسة مل
+
+622
+00:43:09,730 --> 00:43:13,290
+وعملت centrifugation لمدة عشر دقائق بأخذ الـ test
+
+623
+00:43:13,290 --> 00:43:16,950
+tube برفع أربعة مل من الخمسة مل برميهم وبأخلي آخر
+
+624
+00:43:16,950 --> 00:43:20,450
+واحد مل اللي فيه spermatozoa اللي أنا بديها اللي
+
+625
+00:43:20,450 --> 00:43:24,210
+سميتها target spermatozoa ممكن أخد منها عشرة micro
+
+626
+00:43:24,210 --> 00:43:29,210
+وأعمل evaluation للعينة وأشوف كمية الـ sperm من
+
+627
+00:43:29,210 --> 00:43:32,950
+حيث الـ concentration وقداش كمية الـ sperm من حيث
+
+628
+00:43:32,950 --> 00:43:38,130
+motility as percentage طبعاً هذه شكل الـ conical
+
+629
+00:43:38,130 --> 00:43:43,970
+test tube أنا أضفت الـ layer الأولى 2 مل وليكن من
+
+630
+00:43:43,970 --> 00:43:49,690
+الـ media التركيز أو كثافتها 80 بعض الأحيان 90 وطبقة
+
+631
+00:43:49,690 --> 00:43:53,350
+ثانية 2 مل من الـ media اللي كثافتها 40 وبعض الأحيان
+
+632
+00:43:53,350 --> 00:43:56,530
+طبعاً 45 فهو بنبدأ بناء على شركة على شركة في شركة
+
+633
+00:43:56,530 --> 00:43:58,970
+بتعمل 80 40 وفي شركة بتعمل 90 40 و 45
+
+634
+00:43:58,970 --> 00:44:03,710
+40 وكذا بعد أنضفت اتنين مل من العينة أدخلتهم
+
+635
+00:44:03,710 --> 00:44:06,010
+الـ centrifugation بعد انتهاء الـ centrifugation
+
+636
+00:44:06,010 --> 00:44:09,570
+اللي جاءت فيه عند كل الـ seminal fluid في الأعلى بما
+
+637
+00:44:09,570 --> 00:44:14,340
+يحتوي من material unwanted والـ target material
+
+638
+00:44:14,340 --> 00:44:17,440
+الموجودة في الـ sediment بتخلص من الـ supernatant
+
+639
+00:44:17,440 --> 00:44:21,720
+وبضيف عليها خمسة مل من pure washing solution
+
+640
+00:44:21,720 --> 00:44:25,340
+بعملها mixing و centrifugation بعد كده بتخلص من
+
+641
+00:44:25,340 --> 00:44:29,520
+أربعة مل وبأترك الواحد مل كما هو وهو اللي فيه
+
+642
+00:44:29,520 --> 00:44:34,400
+target إذا الواحد مل الأخير هو اللي فيه target
+
+643
+00:44:34,400 --> 00:44:38,500
+spermatozoa with high quality بأخذ منها عشرة micro
+
+644
+00:44:38,500 --> 00:44:41,420
+بعملها evaluation assessment عشان يشوف كداش الـ
+
+645
+00:44:41,420 --> 00:44:44,410
+total count كداش الـ concentration، كداش الـ
+
+646
+00:44:44,410 --> 00:44:47,330
+motility، كداش الـ progressive motility، و كده بتكون
+
+647
+00:44:47,330 --> 00:44:52,930
+العينة جاهزة للـ exit سنستكفي بهذا القدر إن شاء الله
+
+648
+00:44:52,930 --> 00:44:58,090
+على أمل أن نلتقي في محاضرات مستقبلية تم تم في حفظ
+
+649
+00:44:58,090 --> 00:44:59,270
+الوريعات 
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/C8pUDf7Uze8.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/C8pUDf7Uze8.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ee48f3a9b53ed4c6aa8657620bd900dc898477bc
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/C8pUDf7Uze8.srt
@@ -0,0 +1,2111 @@
+1
+00:00:01,250 --> 00:00:05,090
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:05,090 --> 00:00:09,750
+المرسلين سيدنا محمد الصادق الأمين  أما بعد بداية
+
+3
+00:00:09,750 --> 00:00:14,970
+نرحب بكم في مصاف مواضيع خاصة في العلوم الطبية
+
+4
+00:00:14,970 --> 00:00:19,980
+المخبرية لطلبة الماجستير المستوى الثاني نتحدثنا في
+
+5
+00:00:19,980 --> 00:00:25,200
+اللقاء التعريفي عن محتويات هذا المقرر وقد أسلفنا 
+
+6
+00:00:25,200 --> 00:00:29,840
+أن هذا المقرر سوف يتحدث عن تقنية مهمة جدا وهي
+
+7
+00:00:29,840 --> 00:00:33,580
+تقنية التلقيح الصناعي أو أطفال الأنابيب أو ما 
+
+8
+00:00:33,580 --> 00:00:38,380
+يُعرف حاليا بالحقن المجهري حكينا أن هناك ثلاث طرق
+
+9
+00:00:38,380 --> 00:00:44,160
+مختلفة هي عبارة عن عملية التلقيح الصناعي أو أطفال 
+
+10
+00:00:44,160 --> 00:00:47,970
+الأنابيب وهي عبارة عن الطريقة التقليدية ثم ارتقت
+
+11
+00:00:47,970 --> 00:00:52,390
+فيما بعد إلى الحقن المجهري الذي يُعرف باختصار  ICSI
+
+12
+00:00:52,390 --> 00:00:57,590
+أي Intracytoplasmic sperm injection تكلمنا في 
+
+13
+00:00:57,590 --> 00:01:01,670
+البداية عن محتوى هذا المقرر ما على الطلاب من 
+
+14
+00:01:01,670 --> 00:01:06,070
+واجبات وما على المدرس من التزامات وواجبات أيضا
+
+15
+00:01:06,070 --> 00:01:10,950
+توقفنا عند أسباب الـ ICSI واليوم سنستكمل هذا الموضوع 
+
+16
+00:01:10,950 --> 00:01:15,520
+حول مصطلح مهم جدا وهو الـ infertility  الـ infertility
+
+17
+00:01:15,520 --> 00:01:20,600
+كلمة تعني عدم القدرة على الإنجاب فالـ infertility 
+
+18
+00:01:20,600 --> 00:01:26,500
+كلمة بشكلها العام و شكلها المعروف هي عدم قدرة
+
+19
+00:01:26,500 --> 00:01:31,040
+الزوجين على الحصول على طفل خلال فترة زمنية معينة
+
+20
+00:01:31,040 --> 00:01:35,480
+ولكن للأسف في مجتمعنا الحالي أو مجتمعنا المتواجد
+
+21
+00:01:35,480 --> 00:01:40,220
+الآن هناك اختلاف في المعنى ما بين العقم وعدم 
+
+22
+00:01:40,220 --> 00:01:44,020
+القدرة على الإنجاب  وأسلفنا فيما سبق أن العقم هو 
+
+23
+00:01:44,020 --> 00:01:48,420
+الـ sterility وعدم القدرة على الإنجاب بأي شكل من 
+
+24
+00:01:48,420 --> 00:01:53,480
+الأشكال أما الـ infertility وهي عبارة عن مشكلة 
+
+25
+00:01:53,480 --> 00:01:58,640
+يواجهها بعض الناس أو بعض العائلات هي عبارة عن تأخر
+
+26
+00:01:58,640 --> 00:02:02,380
+الإنجاب أو عدم القدرة على الإنجاب بالطريقة 
+
+27
+00:02:02,380 --> 00:02:06,120
+التقلدية وللأسف، بناء على العادات والتقاليد 
+
+28
+00:02:06,120 --> 00:02:09,860
+الموجودة في مجتمعنا دائما أي couple  تبدو حياة 
+
+29
+00:02:09,860 --> 00:02:14,620
+جديدة متى سوف يتم الإنجاب وينتأخر الإنجاب لفترة 
+
+30
+00:02:14,620 --> 00:02:18,940
+زمنية بسيطة تقدر بشهور ولو خمسة شهور أو ستة شهور 
+
+31
+00:02:18,940 --> 00:02:24,100
+أو سنة يصنفهم المجتمع يصنفهم على أنهم infertile أو 
+
+32
+00:02:24,100 --> 00:02:28,000
+غير قادر على الإنجاب طبعا هذا مصطلح خاطئ جدا 
+
+33
+00:02:28,000 --> 00:02:33,320
+وتصنيف خاطئ جدا التعريف العلمي للـ infertility هي 
+
+34
+00:02:33,320 --> 00:02:38,170
+عبارة عن عدم القدرة على الإنجاب بشرط في فترة زمنية 
+
+35
+00:02:38,170 --> 00:02:45,290
+تقدر بسنة واحدة من بعد الزواج بشرط أن يكون هناك 
+
+36
+00:02:45,290 --> 00:02:52,610
+نية للإنجاب بشكل مستمر علشان كده يُعرف بإنه يُعرف 
+
+37
+00:02:52,610 --> 00:02:56,150
+هذا المصطلح بإنه usually defined as inability to
+
+38
+00:02:56,150 --> 00:03:01,010
+get pregnant after trying for one year of regular
+
+39
+00:03:01,010 --> 00:03:05,010
+sexual intercourse without any contraceptive يعني
+
+40
+00:03:05,010 --> 00:03:08,910
+في عندك couple  عندهم الرغبة في الإنجاب و
+
+41
+00:03:08,910 --> 00:03:13,970
+بيحاولوا .. وبيحاولوا بيسعوا في الإنجاب للحصول 
+
+42
+00:03:13,970 --> 00:03:16,670
+على طفل سواء كان طبعا male أو female بغض النظر عن
+
+43
+00:03:16,670 --> 00:03:20,810
+جنس المولود حاليا ولكن لا يملكون القدرة خلال هذه 
+
+44
+00:03:20,810 --> 00:03:23,910
+السنة إذا فقدوا القدرة على الإنجاب نسميهم
+
+45
+00:03:23,910 --> 00:03:29,090
+infertile طب هل الـ infertility تعتبر مشكلة؟ وهل 
+
+46
+00:03:29,090 --> 00:03:33,920
+تصنف بناء على التصنيفات الطبية مشكلة؟صحيح تعتبر
+
+47
+00:03:33,920 --> 00:03:37,300
+من أكثر المشاكل انتشارا سواء كان في المجتمع 
+
+48
+00:03:37,300 --> 00:03:41,980
+الغربي أو المجتمع العربي أو الشرقي رغم كثافة 
+
+49
+00:03:41,980 --> 00:03:46,760
+السكانية الموجودة زيها زي السمنة زيها زي الـ
+
+50
+00:03:46,760 --> 00:03:52,100
+Diabetes زيها زي blood pressure تصنف كحالة مرضية
+
+51
+00:03:52,100 --> 00:03:57,860
+حول العالم تقدر الـ infertility بحوالي 8 إلى 12%
+
+52
+00:03:57,860 --> 00:04:00,790
+between couple  يعني عندي لو أنا عندي many
+
+53
+00:04:00,790 --> 00:04:06,690
+couples منهم 12% يصنفوا على إنهم infertile على 
+
+54
+00:04:06,690 --> 00:04:09,670
+سبيل المثال في الـ United States كانت النسبة أعلى
+
+55
+00:04:09,670 --> 00:04:13,530
+تصل إلى 15% يعني لو أنا عندي many couples بطلّق
+
+56
+00:04:13,530 --> 00:04:18,250
+منهم 15 couple infertile ولو توجهنا إلى المجتمعات 
+
+57
+00:04:18,250 --> 00:04:23,570
+الغربية هنلاقي كنسبة بتزيد يعني على سبيل المثال
+
+58
+00:04:23,570 --> 00:04:27,190
+ألمانيا بلاقي نسبة الـ infertility عالية جدا والـ
+
+59
+00:04:27,190 --> 00:04:32,300
+infertility دي مش سببها أمور طبية، ولكن فقدان الـ 
+
+60
+00:04:32,300 --> 00:04:36,540
+couple  الرغبة في اقتناء طفل أو امتلاك طفل أو
+
+61
+00:04:36,540 --> 00:04:40,780
+الحصول على طفل طبيعة مجتمع، طبيعة عاداته تقاليد في 
+
+62
+00:04:40,780 --> 00:04:45,440
+الـ United States حوالي 15 أو 10% من السيدات اللي 
+
+63
+00:04:45,440 --> 00:04:52,020
+عمهم يتروح ما بين 15 إلى 44 سنة يصنفوا بعدم القدرة 
+
+64
+00:04:52,020 --> 00:04:56,900
+على الإنجاب بشكل طبيعي أو عدم القدرة على الاحتفاظ 
+
+65
+00:04:56,900 --> 00:05:01,200
+بالجنين بشكل طبيعي ليش صنف الـ 15 لأربع
+
+66
+00:05:01,200 --> 00:05:04,540
+و أربعين سنة؟ لأن الـ 15 و الأربع و أربعين سنة
+
+67
+00:05:04,540 --> 00:05:08,680
+العمر الواقع ما بينهم يعتبر هو سن الإنجاب عند 
+
+68
+00:05:08,680 --> 00:05:13,900
+السيدة فحوالي من كل مئة سيدة عمرها 15 إلى أربع
+
+69
+00:05:13,900 --> 00:05:18,020
+و أربعين سنة بطلّع منها عشر سيدات تفقد القدرة على
+
+70
+00:05:18,020 --> 00:05:22,360
+الاحتفاظ بالجنين غير قادرة على الإنجاب بشكل طبيعي 
+
+71
+00:05:22,360 --> 00:05:28,820
+وتصنف بأنها infertile بأنها infertile، هذا التعريف
+
+72
+00:05:28,820 --> 00:05:32,680
+الأساسي هل هناك تعريف آخر للـ infertility؟ أكيد 
+
+73
+00:05:32,680 --> 00:05:36,020
+هناك تعريف آخر لـ infertility فعلى سبيل المثال لو
+
+74
+00:05:36,020 --> 00:05:39,120
+أنا عرفت الـ infertility according to reproductive
+
+75
+00:05:39,120 --> 00:05:42,940
+age يعني بمنظور آخر أنا بدي أصنف الـ infertility 
+
+76
+00:05:42,940 --> 00:05:46,660
+بناء على العمر الإنجابي، طبعا الـ male له عمر
+
+77
+00:05:46,660 --> 00:05:51,100
+إنجابي يختلف عن الـ female  الذكر عمر الإنجابي من 16
+
+78
+00:05:51,100 --> 00:05:57,480
+حوالي لـ 60 أو لـ 50 طبعا زيادة العمر هيأثر على الـ 
+
+79
+00:05:57,480 --> 00:06:01,320
+ability of production عند الـ male بينما الـ female الـ
+
+80
+00:06:01,320 --> 00:06:06,160
+reproductive age محدود يقدر من على سبيل المثال من
+
+81
+00:06:06,160 --> 00:06:11,720
+مجتمع لمجتمع يختلف من 15 سنة لـ 35 سنة لـ 40 سنة
+
+82
+00:06:11,720 --> 00:06:16,190
+ماكسيمام هذا عبارة عن العمر الإنجابي عند السيدة طب
+
+83
+00:06:16,190 --> 00:06:18,830
+العمر الإنجابي عند الـ male أطول؟ أكيد أطول وحنا 
+
+84
+00:06:18,830 --> 00:06:22,990
+نعرف السبب كمان شوية إذا لو أنا قسمت الـ
+
+85
+00:06:22,990 --> 00:06:26,170
+infertility أو عرفت الـ infertility بتعريف آخر بناء 
+
+86
+00:06:26,170 --> 00:06:30,410
+على الـ reproductive age هو عدم قدرة الـ couple 
+
+87
+00:06:30,410 --> 00:06:34,930
+على الإنجاب أو على الحصول على طفل خلال الفترة 
+
+88
+00:06:34,930 --> 00:06:39,970
+الإنجابية التي تتروح من 15 لـ 49 سنة إذا اندمجت الـ
+
+89
+00:06:39,970 --> 00:06:43,230
+male مع الـ female to become or remain pregnant
+
+90
+00:06:43,610 --> 00:06:46,970
+within five years of exposure to pregnancy يعني
+
+91
+00:06:46,970 --> 00:06:52,750
+أنا عندي سيدات عمرهم يتروح من 15 إلى 49 سنة فقدوا 
+
+92
+00:06:52,750 --> 00:06:57,410
+القدرة على الإنجاب لمدة خمس سنوات متتالية رغم
+
+93
+00:06:57,410 --> 00:07:00,850
+المحاولة
+
+94
+00:07:00,850 --> 00:07:06,290
+المستمرة من أجل إنجاب طفل نسميها infertile تعريف
+
+95
+00:07:06,290 --> 00:07:10,370
+آخر نسمي inability to become pregnant with live
+
+96
+00:07:10,370 --> 00:07:14,780
+pairs within five years of exposure based on
+
+97
+00:07:14,780 --> 00:07:19,100
+constant unique status بمعنى آخر أن هذه الـ women
+
+98
+00:07:19,100 --> 00:07:25,780
+تفقد القدرة على الإنجاب خلال خمس سنوات من المحاولة
+
+99
+00:07:25,780 --> 00:07:29,720
+على الإنجاب ولكن هنا صنف الـ infertility كأنها 
+
+100
+00:07:29,720 --> 00:07:34,000
+infertility ليس فقط القدرة على الحمل فقط ولكن 
+
+101
+00:07:34,000 --> 00:07:38,620
+القدرة على الحصول على live baby live birth يعني سيدة
+
+102
+00:07:38,620 --> 00:07:44,900
+تحمل وتحصل على طفل حيعيش على قيد الحياة، يعني تصل
+
+103
+00:07:44,900 --> 00:07:49,240
+لمرحلة الولادة، فهذا تعريف آخر للـ infertility بشرط
+
+104
+00:07:49,240 --> 00:07:53,960
+... بشرط أن هذه السيدة تكون ما زالت محافظة على
+
+105
+00:07:53,960 --> 00:07:59,560
+الرغبة في الإنجاب غير مرضعة ولا تتناول موانع حمل،
+
+106
+00:07:59,560 --> 00:08:02,880
+نسميها oral contraception طب ليه السيدة أو ليش
+
+107
+00:08:02,880 --> 00:08:07,690
+محافظة على الثلاث معايير الأساسية؟ أن السيدة ما زالت
+
+108
+00:08:07,690 --> 00:08:11,170
+تملك القدرة على الإنجاب لأن هذه الأمور لها علاقة
+
+109
+00:08:11,170 --> 00:08:14,710
+بالأمور النفسية كمان شوية هنتعرف أن الأمور النفسية
+
+110
+00:08:14,710 --> 00:08:16,950
+والـ depression اللي بتعرض إليها الـ male و الـ 
+
+111
+00:08:16,950 --> 00:08:20,870
+female يعمل على إنقاص القدرة على الإنجاب No
+
+112
+00:08:20,870 --> 00:08:25,130
+lactation أو lacting لأن عملية الإرضاع للطفل تؤدي
+
+113
+00:08:25,130 --> 00:08:28,690
+إلى تأخير عملية الـ ovulation فبالتالي تؤدي إلى
+
+114
+00:08:28,690 --> 00:08:32,950
+تأخير عملية الإنجاب لأن ما بنعرف أن هرمون الحليب
+
+115
+00:08:33,760 --> 00:08:38,380
+الـ LH يؤثر على الدورة الخاصة بالسيدة، مما يؤدي
+
+116
+00:08:38,380 --> 00:08:42,040
+إلى تأخير عملية الإباضة، مما يؤدي إلى تأخير الحمل
+
+117
+00:08:42,040 --> 00:08:45,020
+السبب الثالث هو الـ oral contraceptive الممكن
+
+118
+00:08:45,020 --> 00:08:49,160
+تتناولها السيدة من أجل منع عملية الحمل فبالتالي، 
+
+119
+00:08:49,160 --> 00:08:54,020
+السيدة حافظة على الرغبة في الإنجاب لم تتناول
+
+120
+00:08:54,020 --> 00:08:58,960
+موانع حمل وغير مرضعة، ولكنها غير قادرة على الإنجاب
+
+121
+00:08:58,960 --> 00:09:05,000
+أو الحصول على طفل حي، مولود حي يعني بتحصل على جنين
+
+122
+00:09:05,000 --> 00:09:11,080
+حي بعد 9 شهور لمدة خمس سنوات متواصلة يمكن أن تصنف
+
+123
+00:09:11,080 --> 00:09:16,620
+بأنها infertile ما هي أسباب الـ infertility عند الـ 
+
+124
+00:09:16,620 --> 00:09:19,940
+male وما هي أسباب الـ infertility عند الـ female؟
+
+125
+00:09:19,940 --> 00:09:24,140
+وهل هناك أسباب مختلفة أو أسباب متشابهة؟ أكيد تبع 
+
+126
+00:09:24,140 --> 00:09:29,450
+الجنس و الـ reproductive age هناك أسباب مختلفة سنبدأ
+
+127
+00:09:29,450 --> 00:09:33,030
+بأسباب الـ infertility عند الأنثى وأولهم هيعرف اسم
+
+128
+00:09:33,030 --> 00:09:36,970
+tubular blockage تكلمنا في المحاضرة السابقة أن الـ 
+
+129
+00:09:36,970 --> 00:09:41,070
+reproductive system عند الأنثى بيبدأ بالـ cervix،
+
+130
+00:09:41,070 --> 00:09:44,290
+بعدين الرحم أو عنق الرحم خلّيني أسميه، بعدين 
+
+131
+00:09:44,290 --> 00:09:48,610
+الرحم، بعدين قنوات فالوب، بعدين المبيض هذا هو عبارة
+
+132
+00:09:48,610 --> 00:09:51,690
+عن الـ reproductive system عند السيدة أي مشكلة في
+
+133
+00:09:51,690 --> 00:09:56,370
+أي منطقة من تلك المناطق تؤدي إلى حدوث infertility
+
+134
+00:09:56,660 --> 00:10:02,420
+قد تكون دائمة وقد تكون مؤقتة تحل بالعلاج قد يكون 
+
+135
+00:10:02,420 --> 00:10:06,240
+علاج عن طريق medication وقد يكون علاج يستوجب 
+
+136
+00:10:06,240 --> 00:10:09,640
+الجراحة سنتحدث عن هذا الموضوع أول سبب من أسباب الـ
+
+137
+00:10:09,640 --> 00:10:13,300
+infertility هو عبارة عن انغلاق في الأنابيب أي 
+
+138
+00:10:13,300 --> 00:10:18,820
+أنابيب أشهرها الفالوبيان تيوب أول سبب من الأسباب
+
+139
+00:10:18,820 --> 00:10:23,180
+التي تؤدي إلى تأخر الإنجاب عند السيدة هو انغلاق 
+
+140
+00:10:23,180 --> 00:10:27,990
+الأنابيب انغلاق الأنابيب شو بيعمل؟ ببساطة جدا أول 
+
+141
+00:10:27,990 --> 00:10:32,550
+شغلة بشكل تلقائي يمنع وصول ال sperm إلى ال oocyte
+
+142
+00:10:32,550 --> 00:10:37,310
+لإن ال oocyte وهي البويضة إذا كانت ناضجة تلقح في
+
+143
+00:10:37,310 --> 00:10:42,010
+الفلوبيا نتيوب و لكي يتم التلقيح في الفلوبيا نتيوب
+
+144
+00:10:42,010 --> 00:10:46,230
+يجب على ال sperm أن يقطع منطقة عنق الرحم والرحم
+
+145
+00:10:46,230 --> 00:10:49,750
+ليصل إلى الفلوبيا نتيوب ويلقح البويضة في هذا
+
+146
+00:10:49,750 --> 00:10:53,930
+المكان فإذا صار عندي blockage في الفلوبيا نتيوب
+
+147
+00:10:53,930 --> 00:10:57,890
+يُعيقها  ال sperm أن يصل إلى ال Targeted Place اللي موجود
+
+148
+00:10:57,890 --> 00:11:01,870
+فيها البويضة فبالتالي مش هيصير عملية التلقيح إذن
+
+149
+00:11:01,870 --> 00:11:07,690
+أول شغلة أن الـ Tubular Blockage تُمَنّع الـ Pregnancy
+
+150
+00:11:07,690 --> 00:11:12,490
+من خلال منع ال sperm من الوصول إلى البويضة و تلقيحها
+
+151
+00:11:12,490 --> 00:11:19,150
+أو من خلال منع وصول البويضة الملقحة إلى الرحم لأن
+
+152
+00:11:19,150 --> 00:11:23,370
+البويضة بعد ما تتلقح في ال Fallopian Tube المفروض
+
+153
+00:11:23,600 --> 00:11:26,780
+تسافر من الـ Fallopian tube حتى تصل إلى الرحم
+
+154
+00:11:26,780 --> 00:11:31,600
+وتنغرز في بطانة الرحم لتكوين الجنين اللي فيما بعد
+
+155
+00:11:31,600 --> 00:11:35,200
+يكوّن الـ Placenta أو لتكوين الـ Placenta التي تؤدي 
+
+156
+00:11:35,200 --> 00:11:41,540
+إلى مصدر غذاء للجنين فعندي طريقتين أو two way للـ
+
+157
+00:11:41,540 --> 00:11:45,940
+Tubular Blockage التي تؤدي لمنع الحمل أول حاجة منع
+
+158
+00:11:45,940 --> 00:11:49,400
+وصول الحيوان المنوي ال sperm إلى البويضة مما يمنع
+
+159
+00:11:49,400 --> 00:11:54,210
+التلقيح  منع انتقال البويضة الملقحة من الـ Fallopian
+
+160
+00:11:54,210 --> 00:11:58,310
+tube إلى الرحم مما يؤدي إلى عدم تكوين الجنين
+
+161
+00:11:58,310 --> 00:12:02,410
+فبالتالي المحصلة هي فشل في الحمل السبب الثاني
+
+162
+00:12:02,410 --> 00:12:05,950
+عند الفيميل حاجة بنتسميها Endometriosis ببساطة جدا
+
+163
+00:12:05,950 --> 00:12:09,270
+Endometriosis مصطلح من ال Endometrium و ال
+
+164
+00:12:09,270 --> 00:12:13,350
+Endometrium هي عبارة عن النسيج المبطن للرحم أو
+
+165
+00:12:13,350 --> 00:12:17,690
+بطانة الرحم بسموها في بعض الأحيان وبعض الحالات
+
+166
+00:12:17,690 --> 00:12:21,690
+المرضية بيصير في عندي خلل في الأنسجة المبطنة للرحم
+
+167
+00:12:21,690 --> 00:12:25,410
+اللي بنسميها بطانة الرحم أو ال Endometrium فبيصير
+
+168
+00:12:25,410 --> 00:12:30,030
+إليها انتقال أو نمو خارج الرحم انتقال ال
+
+169
+00:12:30,030 --> 00:12:35,310
+Endometrium ونموها خارج الرحم يؤدي إلى تكوين
+
+170
+00:12:35,310 --> 00:12:39,150
+Pregnancy Failure يؤدي إلى تكوين Pregnancy Failure
+
+171
+00:12:39,150 --> 00:12:43,800
+لأنه بيبمنع عملية التبويض أصلا أو قد يمنع وصول
+
+172
+00:12:43,800 --> 00:12:48,320
+البويضة الملقحة إلى المكان المناسب لتكوين الجنين
+
+173
+00:12:48,320 --> 00:12:51,560
+داخل الرحم السبب الثالث بنسميه حاجة بنسميها
+
+174
+00:12:51,560 --> 00:12:55,600
+Cervical Factor Cervical Factor يعني عوامل لها
+
+175
+00:12:55,600 --> 00:13:00,520
+علاقة بـ عنق الرحم وأن عنق الرحم يعتبر أول محطات
+
+176
+00:13:00,520 --> 00:13:04,460
+انتقال ال sperm بعد ال...بعد ال...ال...ال...ال...
+
+177
+00:13:04,460 --> 00:13:05,080
+ال...ال...ال...ال...ال...ال...ال...ال...
+
+178
+00:13:05,080 --> 00:13:05,680
+ال...ال...ال...ال...ال...ال...ال...ال...
+
+179
+00:13:05,680 --> 00:13:06,800
+ال...ال...ال...ال...ال...ال...ال...ال...
+
+180
+00:13:06,800 --> 00:13:07,680
+ال...ال...ال...ال...ال...ال...ال...ال...
+
+181
+00:13:07,680 --> 00:13:08,180
+ال...ال...ال...ال...ال...ال...ال...ال...
+
+182
+00:13:08,180 --> 00:13:08,260
+ال...ال...ال...ال...ال...ال...ال...ال...
+
+183
+00:13:08,260 --> 00:13:12,010
+ال...ال...ال...ال...ال...ال...ال...or
+
+184
+00:13:12,010 --> 00:13:15,130
+Antagonist to Sperm يعني في عندي في ال Cervical 
+
+185
+00:13:15,130 --> 00:13:20,190
+Factor Two Factors الأول كمية الميوكاس الموجودة في
+
+186
+00:13:20,190 --> 00:13:26,130
+منطقة ال Cervical كمية قليلة جدا هي أدها way تمنع
+
+187
+00:13:26,130 --> 00:13:30,370
+حدوث ال Pregnancy أو الشيء الثاني أن وجود في منطقة
+
+188
+00:13:30,370 --> 00:13:35,230
+ال Cervical Sperm يعمل ك Antagonist يعني مضاد أو
+
+189
+00:13:35,230 --> 00:13:39,330
+مواد تُستخدَم أو مواد موجودة عفوا مواد موجودة في
+
+190
+00:13:39,330 --> 00:13:42,650
+منطقة ال Cervical تعمل ك Antagonist ضد ال Sperm
+
+191
+00:13:42,650 --> 00:13:45,430
+يعني مجرد ما يتواجد ال Sperm في منطقة ال Cervical
+
+192
+00:13:45,430 --> 00:13:49,210
+هذه المواد بتعمل Destructure لـ ال Sperm فبالتالي
+
+193
+00:13:49,210 --> 00:13:53,350
+ال Sperm يفقد قدرته على الانتقال ثم يفقد قدرته على
+
+194
+00:13:53,350 --> 00:13:57,550
+الإخصاب ال Ant Sperm Antibody من أهم هذه المواد
+
+195
+00:13:57,550 --> 00:14:01,750
+اللتي تعمل ك Antagonist Against Sperm في بعض
+
+196
+00:14:01,750 --> 00:14:05,730
+الأحيان بيكون عندي Two Couples Normal 100% ال Male 
+
+197
+00:14:05,730 --> 00:14:09,650
+و ال Female لاندو كرايم لفل Normal ال Anatomy تبع
+
+198
+00:14:09,650 --> 00:14:12,490
+ال Pelvic عند ال Male و ال Female Normal ال
+
+199
+00:14:12,490 --> 00:14:15,630
+Anatomy ال Productive System عند ال Male و ال
+
+200
+00:14:15,630 --> 00:14:18,890
+Female Normal بنسبة 100% ولكن غير قادرين على
+
+201
+00:14:18,890 --> 00:14:24,090
+الإنجاب السبب أن هذه الزوجة أو هذه ال Female عندها
+
+202
+00:14:24,090 --> 00:14:29,670
+Ant Sperm موجودة في منطقة ال Cervix تشتغل ضد ال
+
+203
+00:14:29,670 --> 00:14:33,730
+Sperm الخاص بهذا الرجل أو خاص بهذا الزوجة فبالتالي
+
+204
+00:14:33,940 --> 00:14:39,820
+لا يحدث تلقيح للبويضة حتى لو كانت البويضة ناضجة
+
+205
+00:14:39,820 --> 00:14:43,360
+لأن ما فيه Sperm بيصل للبويضة الناضجة وبيعملها
+
+206
+00:14:43,360 --> 00:14:48,140
+عملية تلقيح فبالتالي ال Ant Sperm من أهم الأسباب
+
+207
+00:14:48,140 --> 00:14:54,200
+التي تؤدي إلى منع تلقيح البويضة والتي تؤدي إلى قتل
+
+208
+00:14:54,200 --> 00:14:59,200
+الحيوان المنوي بمجرد تواجده في منطقة ال Cervix فمجرد
+
+209
+00:14:59,200 --> 00:15:03,060
+أنه اشتغلت هذا ال Ant Sperm ضد ال Sperm فبيعملها
+
+210
+00:15:03,320 --> 00:15:07,000
+أنتاجونيست بتفقد ال Capacity تبع ال Sperm على ال
+
+211
+00:15:07,000 --> 00:15:11,260
+Fertilization سؤال هل يمكن للذكر تكوين Ant Sperm
+
+212
+00:15:11,260 --> 00:15:14,980
+ضد نفسه أو ضد الحيوانات المنوية الخاصة فيه؟ صحيح
+
+213
+00:15:14,980 --> 00:15:20,560
+يمكن في حالات نادرة رغم علميا أن ال Testes الخاصة
+
+214
+00:15:20,560 --> 00:15:24,620
+بالميل موجودة في منطقة معزولة عن ال Blood Stream
+
+215
+00:15:24,620 --> 00:15:29,020
+بشكل كامل فبالتالي ما في لها ما بتعرضها جهاز
+
+216
+00:15:29,020 --> 00:15:33,420
+المناعة ولكن في لحظة من اللحظات بخطأ طبي بسيط على
+
+217
+00:15:33,420 --> 00:15:36,840
+سبيل المثال لو صار عندك Trauma أو Injury في منطقة
+
+218
+00:15:36,840 --> 00:15:39,800
+ال Testis بيصير في عندك Direct Contact ما بين
+
+219
+00:15:39,800 --> 00:15:44,800
+Immune System و ال Testis فبؤدي إلى تكوين Antibody
+
+220
+00:15:44,800 --> 00:15:48,600
+ضد ال Sperm الخاص بهذا الإنسان فيصبح الإنسان غير
+
+221
+00:15:48,600 --> 00:15:52,260
+قادر على الإنجاب بفعل جهازه المناعي بفعل جهازه
+
+222
+00:15:52,260 --> 00:15:58,140
+المناعي فبتكون السيدة ما الها سبب في تأخر الإنجاب
+
+223
+00:15:58,140 --> 00:16:01,740
+في هذه اللحظة في أمور ثانية بنسميها Cervical Factor
+
+224
+00:16:01,740 --> 00:16:06,140
+Could Be Physical Problem Or Mucus Related Problem
+
+225
+00:16:06,140 --> 00:16:10,340
+بعض الأحيان ال Cervical Factor قسموها إلى عوامل
+
+226
+00:16:10,340 --> 00:16:14,960
+فيزيائية علاقة مثلا بال Thickness الخاصة بالميوكاس
+
+227
+00:16:14,960 --> 00:16:20,220
+أو عوامل ليس لها علاقة بال Physical أبدا فعلى سبيل
+
+228
+00:16:20,220 --> 00:16:25,280
+المثال لو كان عندي Cervical Mucus Very Thick
+
+229
+00:16:25,280 --> 00:16:28,320
+الميوكاس الموجود في منطقة ال Cervical عند السيدة
+
+230
+00:16:28,870 --> 00:16:33,770
+Very Very Very Thick هذا بيعمل كشبكة شبكة مغلقة
+
+231
+00:16:33,770 --> 00:16:39,250
+محكمة الإغلاق تمنع انتقال أي Sperm داخل ال
+
+232
+00:16:39,250 --> 00:16:42,950
+Cervix فبالتالي ما بيقطع ال Cervix وما بيقطع
+
+233
+00:16:42,950 --> 00:16:47,270
+الرحم وما بيصل لل Fallopian Tube فبالتالي ال
+
+234
+00:16:47,270 --> 00:16:51,130
+Fertilization محصلة سفر فماعندي Pregnancy صرفي
+
+235
+00:16:51,130 --> 00:16:55,670
+عندي Infertility ولو كانت موقفة شغل ثاني أقول ليه
+
+236
+00:16:56,310 --> 00:17:00,990
+الـ Physical Problem الخاصة بالـ Cervix لها علاقة
+
+237
+00:17:00,990 --> 00:17:04,750
+بشكل كبير جدا جدا بالـ Miscarriage و ال
+
+238
+00:17:04,750 --> 00:17:09,030
+Miscarriage بشكل أساسي هو عبارة عن الإجهاض الـ
+
+239
+00:17:09,030 --> 00:17:12,870
+Miscarriage زي ال Abortion الإجهاض الـ Mucus
+
+240
+00:17:12,870 --> 00:17:16,510
+Related Problem ممكن يؤدي لميوكس إلى عدة مشاكل
+
+241
+00:17:16,510 --> 00:17:20,750
+بفعل كمية الميوكس الموجودة في ال Cervical غير
+
+242
+00:17:20,750 --> 00:17:25,380
+كافية فبالتالي ال Sperm غير قادر على البقاء طب إيش
+
+243
+00:17:25,380 --> 00:17:28,360
+دخل ال Mucus في بقاء ال Sperm؟ طب إحنا حكينا إن ال
+
+244
+00:17:28,360 --> 00:17:33,080
+Mucus بيقتل ال Sperm خد بالك بيقتل ال Sperm في حالة
+
+245
+00:17:33,080 --> 00:17:37,240
+زيادة ال Thickness تبع ال Mucus فبالتالي وجود ال
+
+246
+00:17:37,240 --> 00:17:41,780
+Mucus في منطقة ال Cervical بيعمل عملية حماية لل
+
+247
+00:17:41,780 --> 00:17:45,380
+Sperm من ال pH الخاص بال Cervical ال pH اللي
+
+248
+00:17:45,380 --> 00:17:49,100
+موجودة عند السيدة لأن ال pH تبع ال Male يختلف عن
+
+249
+00:17:49,100 --> 00:17:53,030
+ال pH تبع ال Female فلو كان في عندي ما عنده
+
+250
+00:17:53,030 --> 00:17:56,150
+Mucus، هيصير عنده Shock للـ Sperm ويصير له
+
+251
+00:17:56,150 --> 00:18:01,650
+Destructure فكمية الـ Mucus المعقولة والكافية تعمل
+
+252
+00:18:01,650 --> 00:18:07,250
+حماية للـ Sperm بعد ال Intercourses من أجل المحافظة
+
+253
+00:18:07,250 --> 00:18:10,390
+على الـ Sperm بال Full Activity الخاصة فيه للوصول
+
+254
+00:18:10,390 --> 00:18:14,830
+إلى ال Fallopian Tube ففي حالة وجود كمية غير كافية
+
+255
+00:18:14,830 --> 00:18:19,770
+من الميوكاس، معناه ال Survivor Rate للـ Sperm هيقل
+
+256
+00:18:19,770 --> 00:18:27,060
+بشكل كبير Is Too Thick For Sperm To Survive لو كان
+
+257
+00:18:27,060 --> 00:18:32,500
+لدي الميوكاس كثافته عالية جدا أو كثافته عالية جدا
+
+258
+00:18:32,500 --> 00:18:37,160
+معناه أن كمية ال Sperm اللي هتصل إلى الفلوبيا
+
+259
+00:18:37,160 --> 00:18:40,620
+هتكون قليلة جدا لأن الميوكاس في هذه اللحظة عمل زي
+
+260
+00:18:40,620 --> 00:18:45,400
+شبكة أسطاد كل Sperm وعملهم Destructure الحاجة
+
+261
+00:18:45,400 --> 00:18:48,980
+الثالثة بيسموها The Mucus Contains Sperm Antibody
+
+262
+00:18:48,980 --> 00:18:53,160
+اتكلمنا عليها في السابق إن الميوكاس نفسه في منطقة
+
+263
+00:18:53,160 --> 00:18:56,780
+الـ Cervix الخاص بالفيميل يحتوي على Antibody
+
+264
+00:18:56,780 --> 00:19:00,580
+طبعا Antibody في هذه اللحظة السيدة التي تصنعه
+
+265
+00:19:00,580 --> 00:19:06,600
+وليس الرجل السيدة وليس الرجل السبب الرابع حاجة
+
+266
+00:19:06,600 --> 00:19:10,740
+بيسمونها الـ Pelvic Adhesion ببساطة في بعض الأحيان
+
+267
+00:19:10,740 --> 00:19:14,900
+السيدات بتتعرض لـ Trauma في منطقة ال Pelvic أو تتعرض
+
+268
+00:19:14,900 --> 00:19:18,300
+لـ Inflammation في منطقة الـ Pelvic أو بتتعرض ل
+
+269
+00:19:18,300 --> 00:19:21,920
+Surgical Operation في منطقة الـ Pelvic عملية الـ
+
+270
+00:19:21,920 --> 00:19:25,620
+Healing للـ Tissue في منطقة الـ Pelvic تؤدي في بعض
+
+271
+00:19:25,620 --> 00:19:29,480
+الأحيان إلى تكوين Pelvic Adhesion الـ Pelvic
+
+272
+00:19:29,480 --> 00:19:32,460
+Adhesion ببساطة زي ما احنا شايفنا في الصورة هي
+
+273
+00:19:32,460 --> 00:19:39,340
+عبارة عن فلمة تطورت، نمت بشكل كبير جدا عملت رابط
+
+274
+00:19:39,340 --> 00:19:42,960
+لبعض الأعضاء الموجودة في منطقة ال Abdominal ومنطقة
+
+275
+00:19:42,960 --> 00:19:47,840
+ال Pelvic عند السيدة فأدت إلى وجود Anatomical ...
+
+276
+00:19:47,840 --> 00:19:50,560
+Anatomical Structure لـ Reproductive System غير
+
+277
+00:19:50,560 --> 00:19:56,000
+طبيعي فأدى إلى عدم القدرة على الإنجاب عدم القدرة
+
+278
+00:19:56,000 --> 00:20:00,000
+على الإنجاب السبب الأساسي أن هذه السيدة اتعرضت ل
+
+279
+00:20:00,000 --> 00:20:04,200
+Trauma Inflammation Surgical Operation في منطقة ال
+
+280
+00:20:04,200 --> 00:20:08,350
+Pelvic بعد فترة صار Healing للـ Tissue الـ Healing 
+
+281
+00:20:08,350 --> 00:20:12,710
+كون الـ Filament أملت ربط لبعض الأعضاء
+
+282
+00:20:12,710 --> 00:20:16,090
+الموجودة في منطقة الـ Pelvic مع بعض البعض فأدى إلى
+
+283
+00:20:16,090 --> 00:20:20,470
+تكوين Abnormal Anatomical Structure أو
+
+284
+00:20:20,470 --> 00:20:25,530
+Abnormal Anatomical Structure أدى إلى تأخر الإنجاب
+
+285
+00:20:25,530 --> 00:20:30,730
+أو حدوث Infertility سبب
+
+286
+00:20:30,730 --> 00:20:34,990
+الخامس الذي يعتبر من أسباب الـ Female Infertility
+
+287
+00:20:34,990 --> 00:20:39,450
+هو عبارة عن Ovulation Disorder يعني السيدة تمام
+
+288
+00:20:39,450 --> 00:20:42,830
+مافيش عندها Anti-Sperm Antibody مافيش عندها Pelvic
+
+289
+00:20:42,830 --> 00:20:46,890
+Adhesion الـ Anatomical Reproductive System Normal
+
+290
+00:20:46,890 --> 00:20:51,950
+ولكن في عندها مشكلة في عملية الـ Ovulation نفسها
+
+291
+00:20:51,950 --> 00:20:56,190
+يعني في عملية التبويض نعرف بشكل أساسي و بشكل مبدئي
+
+292
+00:20:56,190 --> 00:21:00,710
+أن المتعرف عليه أن الـ Menstrual Cycle لأي سيدة 28
+
+293
+00:21:00,710 --> 00:21:04,570
+يوم من إلى من لحظة الـ Bleeding إلى الـ Bleeding
+
+294
+00:21:05,390 --> 00:21:07,930
+التاني الموجود في الـ Cycle التاني يعني 28 يوم
+
+295
+00:21:07,930 --> 00:21:11,510
+ولكن هذا مي ثابت في بعضهم تصل لـ 30 وفي بعضهم تصل
+
+296
+00:21:11,510 --> 00:21:15,750
+لـ 36 يوم زي ما احنا بنعرف أن الـ Bleeding Time
+
+297
+00:21:15,750 --> 00:21:19,610
+ثمانية أيام في بعضهم أربعة في بعضهم عشر في بعض
+
+298
+00:21:19,610 --> 00:21:24,030
+السيدات بيكون عندهم Ovulation Disorder يعني بمعنى
+
+299
+00:21:24,030 --> 00:21:28,110
+آخر أن في عوامل بتأثر على عملية الـ Egg Releasing
+
+300
+00:21:28,110 --> 00:21:31,750
+إيش عن الـ Ovulation؟ Ovulation هي عبارة عن التبويض
+
+301
+00:21:31,750 --> 00:21:35,500
+أو الإباضة إيش معنى التفويض أو الإباضة؟ هي عبارة عن
+
+302
+00:21:35,500 --> 00:21:39,800
+خروج البويضة الناضجة من الـ Ovary إلى قناة
+
+303
+00:21:39,800 --> 00:21:42,500
+Fallopian هذه بسميها الـ Ovulation طبعا دائما
+
+304
+00:21:42,500 --> 00:21:45,520
+بتصير في اليوم الثالث عشر أو اليوم الرابع عشر من
+
+305
+00:21:45,520 --> 00:21:49,600
+الدورة الشهرية اللي بيسميها Menstrual Cycle بعض
+
+306
+00:21:49,600 --> 00:21:54,100
+السيدات عندهم مشكلة في وقت الإباضة أو عندهم مشكلة
+
+307
+00:21:54,100 --> 00:21:57,060
+في قلة الإباضة أو عندهم مشكلة في كيفية الإباضة
+
+308
+00:21:57,060 --> 00:22:00,260
+عندهم عملية إخراج البويضة أو عملية الـ Ovulation
+
+309
+00:22:00,260 --> 00:22:04,260
+بشكل طبيعي لأ ما بتحدث، أسبابها شوف في عندي
+
+310
+00:22:04,260 --> 00:22:07,320
+هرمون، فمش داخل الهرمون في الموضوع هذا؟ ببساطة
+
+311
+00:22:07,320 --> 00:22:10,440
+جدا، عارفين أن الـ Reproductive System و الـ
+
+312
+00:22:10,440 --> 00:22:14,820
+Ovulation ما بيصير إلا تحت تأثير الهرمونات، وأهمها
+
+313
+00:22:14,820 --> 00:22:19,740
+الـ FSH و الـ LH اللي فيما بعد بيحفظ الإنتاج
+
+314
+00:22:19,740 --> 00:22:23,500
+للبروجسترون و الاستروجين، وهذا هناخده بالتفصيل
+
+315
+00:22:23,500 --> 00:22:28,280
+الممل في Chapter رقم 2 إن شاء الله إذا الأول سبب من
+
+316
+00:22:28,280 --> 00:22:31,700
+أسباب الـ Ovulation Disorder أنه في عندي Hormonal
+
+317
+00:22:31,700 --> 00:22:35,860
+Disorder ومن أشهرها الـ Polycystic Ovarian Syndrome
+
+318
+00:22:35,860 --> 00:22:39,180
+شو مقصود بالـ Polycystic Ovarian Syndrome؟ حاجة
+
+319
+00:22:39,180 --> 00:22:45,400
+بيسموها PCOS Polycystic
+
+320
+00:22:45,400 --> 00:22:50,020
+Ovarian Syndrome يعني في عندي تكيسات حول المبيض
+
+321
+00:22:50,020 --> 00:22:56,180
+تمنع عملية الإباضة تحجب عملية الإباضة تمنع خروج
+
+322
+00:22:57,400 --> 00:23:00,800
+البويضة في ناس بتقولك لأ أنه أنا عندي الفوليكل
+
+323
+00:23:00,800 --> 00:23:05,420
+اللي موجودة فيها البويضة بتنتفخ و بتكبر لدرجة أنه
+
+324
+00:23:05,420 --> 00:23:10,640
+أنا لو شوفتها على الـ Ultrasound باعتبرها فوليكل طبيعية
+
+325
+00:23:10,640 --> 00:23:16,140
+تحتوي على بويضة طبيعية ناضجة ولكن لو دققت النظر
+
+326
+00:23:16,140 --> 00:23:20,020
+فيها بلاقي الفوليكل فاضية مافيها بويضة ناضجة عشان
+
+327
+00:23:20,020 --> 00:23:24,620
+كده بيسموها Polycystic Ovary Syndrome Polycystic
+
+328
+00:23:24,620 --> 00:23:29,720
+Ovary Syndrome يعني الفوليكلوصلت للقطر الخاص
+
+329
+00:23:29,720 --> 00:23:33,740
+بالفوليكل الناضجة ولكن في داخلها Zero بويضات
+
+330
+00:23:33,740 --> 00:23:38,440
+ناضجة السبب التاني حاجة بنتسميها Hyperprolactinemia حاجة
+
+331
+00:23:38,440 --> 00:23:44,200
+اللي لها علاقة بالـ Prolactin يعني 
+
+332
+00:23:44,200 --> 00:23:47,960
+هرمون الحليب اللي لها علاقة بهرمون الحليب زيادة
+
+333
+00:23:47,960 --> 00:23:53,080
+في مستوى هرمون الحليب Prolactin Hormone حاجة
+
+334
+00:23:53,080 --> 00:23:56,730
+بنتسميها Hyperprolactinemia يعني مستوى هرمون الحليب
+
+335
+00:23:56,730 --> 00:24:01,330
+بيكون عالي جدا فبتتأخر عملية التبويض اللي احنا
+
+336
+00:24:01,330 --> 00:24:05,070
+بنسميها بالمصطلح العام تأخر الدورة عشان كده معظم
+
+337
+00:24:05,070 --> 00:24:07,990
+السيدات اللي بينجبوا و بكونوا في مرحلة الرضاعة الـ
+
+338
+00:24:07,990 --> 00:24:11,150
+Lactation بلاقي الدورة ما بتيجي بشكل منتظم أو
+
+339
+00:24:11,150 --> 00:24:15,330
+بتتأخر شهرين تلاتة و ممكن تتأخر سنة كاملة عند بعض
+
+340
+00:24:15,330 --> 00:24:21,210
+السيدات السبب التالت للـ Ovulation Disorder هي Too
+
+341
+00:24:21,210 --> 00:24:24,890
+Much Thyroid Hormone اللي بنسميها Hyperthyroidism
+
+342
+00:24:24,890 --> 00:24:28,630
+أو Hypothyroidism سيدة عندها Thyroid Hormone
+
+343
+00:24:28,630 --> 00:24:32,270
+Activity عالي جدا بتسميها Hyperthyroidism أو Very
+
+344
+00:24:32,270 --> 00:24:36,430
+Low بتسميها Hypothyroidism وهذا بيأثر بشكل كبير
+
+345
+00:24:36,430 --> 00:24:41,270
+جدا على الـ Ovulation و الـ Menstrual Cycle عشان كده
+
+346
+00:24:41,270 --> 00:24:45,490
+أي سيدة خدوا بالكوا أي سيدة بتروح تعمل إخصاب
+
+347
+00:24:45,490 --> 00:24:49,990
+صناعي أو حقن مجهري بيقصولها هرمونات الـ FSH
+
+348
+00:24:49,990 --> 00:24:57,180
+و الـ LH و الـ E2 و الـ TSH هو Thyroid Stimulating
+
+349
+00:24:57,180 --> 00:25:00,280
+Hormone Thyroid Stimulating Hormone وكمان هرمون
+
+350
+00:25:00,280 --> 00:25:05,340
+جديد بيسموه AMH Anti-Müllerian Hormone وهنتكلم عنه
+
+351
+00:25:05,340 --> 00:25:09,360
+باستفاضة شو هو الـ Anti-Müllerian Hormone علشان
+
+352
+00:25:09,360 --> 00:25:14,140
+كده مهم جدا الـ Prolactin يكون طبيعي مهم جدا الـ
+
+353
+00:25:14,140 --> 00:25:18,960
+FSH يكون طبيعي مهم جدا الـ LH يكون طبيعي مهم جدا الـ
+
+354
+00:25:18,960 --> 00:25:24,960
+E2 مهم جدا الـ TSH يكون طبيعي قبل الزوجة أو السيدة
+
+355
+00:25:24,960 --> 00:25:31,140
+ما تروح تعمل إخصاب وإلا هتدخل في برنامج علاجي يرجع
+
+356
+00:25:31,140 --> 00:25:35,520
+هذه الهرمونات لوضعها كالطبيعي الـ Other Causes اللي
+
+357
+00:25:35,520 --> 00:25:39,960
+بتأدي إلى الـ Ovulation Disorder بعض الأحيان أن هذه
+
+358
+00:25:39,960 --> 00:25:45,080
+السيدة بتعمل Exercise بشكل Hard Exercise Hard
+
+359
+00:25:45,080 --> 00:25:50,490
+Exercise بيؤدي إلى حدوث تلف عندها في بعض المناطق
+
+360
+00:25:50,490 --> 00:25:54,050
+الخاصة بالـ Reproductive System Eating Disorder أو
+
+361
+00:25:54,050 --> 00:26:00,190
+Tumor بعض الأحيان بيصير عندها Tumor في منطقة الـ
+
+362
+00:26:00,190 --> 00:26:04,650
+Pelvic Tumor في الـ Ovary Tumor في الـ Fallopian Tube
+
+363
+00:26:04,650 --> 00:26:10,530
+تمنع عملية الـ Ovulation بالشكل الطبيعي سبب سادس من
+
+364
+00:26:10,530 --> 00:26:15,050
+أسباب الـ Female Infertility وهو Primary Ovarian
+
+365
+00:26:15,050 --> 00:26:15,770
+Insufficiency
+
+366
+00:26:18,060 --> 00:26:20,240
+What's the meaning of the Primary or Variant
+
+367
+00:26:20,240 --> 00:26:24,200
+Sufficient هو عبارة عن الـ Early Menopause الـ
+
+368
+00:26:24,200 --> 00:26:27,740
+Menopause أنا ما بدي أسميها فترة اليأس أو زمن
+
+369
+00:26:27,740 --> 00:26:32,500
+اليأس أو وقت اليأس أنا بسميها لبساطة جدا انقطاع
+
+370
+00:26:32,500 --> 00:26:37,700
+الدورة أو انقطاع الطمث بعضهم من أجل تغيير الوصولات
+
+371
+00:26:37,700 --> 00:26:43,100
+بيسميها سن اليأس لأ هو عبارة عن وقت انقطاع الدورة
+
+372
+00:26:43,100 --> 00:26:47,980
+أو وقت انقطاع الطمث بسموها Menopause في هذا السبب
+
+373
+00:26:47,980 --> 00:26:52,220
+اللي بنسميه Primary Ovarian Insufficiency إله اسم
+
+374
+00:26:52,220 --> 00:26:56,980
+آخر وهو الـ Early Menopause السيدة بشكلها الطبيعي
+
+375
+00:26:56,980 --> 00:27:00,040
+وبعمرها الطبيعي و الـ Physiological الطبيعية
+
+376
+00:27:00,040 --> 00:27:03,100
+الخاصة فيها تصل لـ Menopause 41 و
+
+377
+00:27:03,100 --> 00:27:05,860
+42 و 44 سنة يعني لما تصل لعمر من
+
+378
+00:27:05,860 --> 00:27:08,020
+40 لـ 42 و 44 سنة المفروض كانت وصلت لـ
+
+379
+00:27:08,020 --> 00:27:10,940
+Menopause وهنعرف إيش الأسباب التي تؤدي إلى الـ
+
+380
+00:27:10,940 --> 00:27:16,830
+Menopause ولكن لكل قاعدة شواذ في بعض السيدات ما
+
+381
+00:27:16,830 --> 00:27:20,290
+بتصل لـ Menopause على الـ 40 بتصل على 35 هذا
+
+382
+00:27:20,290 --> 00:27:25,250
+بنتسميها Early Menopause Early Menopause وطبعا
+
+383
+00:27:25,250 --> 00:27:29,390
+بعضهم أو بعض المقالات بتقولك أنه و بعض المراجع
+
+384
+00:27:29,390 --> 00:27:34,530
+بتقولك أن أسبابها Unknown حتى الآن ولكن في Factors
+
+385
+00:27:34,530 --> 00:27:39,850
+تساعد و ترتبط بالـ Early Menopause منها عندك Problem
+
+386
+00:27:39,850 --> 00:27:42,790
+في الـ Immune System بيصير الـ Immune System يشتغل
+
+387
+00:27:42,790 --> 00:27:48,070
+على البويضات المخزنة بيدمرها وبتصل لـ 35-36 ما
+
+388
+00:27:48,070 --> 00:27:52,010
+بيكون عندها مخزون وبتتوقف الدورة عندها أو بعض اللي
+
+389
+00:27:52,010 --> 00:27:54,410
+أحيان بيقولك في عندي Genetical Condition زي
+
+390
+00:27:54,410 --> 00:27:58,790
+الـ Turner Syndrome زي الـ Fragile X Syndrome أو
+
+391
+00:27:58,790 --> 00:28:01,530
+بعض السيدات اللي بتتعرضوا للـ Radiotherapy و الـ
+
+392
+00:28:01,530 --> 00:28:06,150
+Chemotherapy إذا هذه عبارة عن تلات عوامل أساسية
+
+393
+00:28:06,150 --> 00:28:11,860
+تساعد و تدفع السيدة للوصول إلى الـ Early Menopause
+
+394
+00:28:11,860 --> 00:28:15,840
+قبل الوقت الطبيعي يعني قبل الأربعين في خلصنا تلقين
+
+395
+00:28:15,840 --> 00:28:21,420
+ستة أولوية طيب خلصنا من أسباب الـ Menopause عند
+
+396
+00:28:21,420 --> 00:28:25,500
+الـ Female عفوا خلصنا عند أعراض الـ Menopause أو
+
+397
+00:28:25,500 --> 00:28:29,820
+Early Menopause عند الـ Female وبالتالي أنهينا
+
+398
+00:28:29,820 --> 00:28:34,460
+الأسباب التي تؤدي إلى الـ Female Infertility نيجي
+
+399
+00:28:34,460 --> 00:28:37,000
+لـ Male Infertility ولكن قبل ما نيجي لـ Male
+
+400
+00:28:37,000 --> 00:28:44,480
+Infertility مش صح إنه أنا أرجع و أعود بأسباب الـ
+
+401
+00:28:44,480 --> 00:28:48,240
+Infertility إلى شخص دون الآخر أو إلى جنس دون الآخر
+
+402
+00:28:48,240 --> 00:28:52,420
+ولا بقول إن الـ Infertility لها علاقة بالـ Female أو
+
+403
+00:28:52,420 --> 00:28:56,200
+لها علاقة بالـ Male لأ في أسباب خاصة بالـ Male في
+
+404
+00:28:56,200 --> 00:28:59,600
+أسباب خاصة بالـ Female فبالتالي قبل ما أطلق أي حاجة
+
+405
+00:28:59,600 --> 00:29:04,640
+وأقول إن الـ Infertility خاصة بالـ Female فبالتالي
+
+406
+00:29:04,640 --> 00:29:08,690
+لازم أنا أستشير طبيب أستشير أخصائي الـ Embryologist
+
+407
+00:29:08,690 --> 00:29:13,050
+أعمل الفحوصات المطلوبة عشان أحدد السبب علشان بعد
+
+408
+00:29:13,050 --> 00:29:17,230
+تحديد السبب بدأ العلاج فبالتالي ما بلقي التهم
+
+409
+00:29:17,230 --> 00:29:22,750
+جوازافة أسباب الـ Male Infertility بداية لما أقول
+
+410
+00:29:22,750 --> 00:29:27,110
+أنا عندي Infertility عند الـ Male معناه إن هذا الـ
+
+411
+00:29:27,110 --> 00:29:33,920
+Male قد ينتج Seminal Fluid ولكن مافيش Sperm أو قد
+
+412
+00:29:33,920 --> 00:29:38,000
+ينتج Seminal Fluid وفي Sperm ولكن الـ Sperm Non
+
+413
+00:29:38,000 --> 00:29:41,840
+-Functional يعني بمعنى آخر ممكن يكون أنا عندي
+
+414
+00:29:41,840 --> 00:29:46,040
+مشكلة في الـ Seminal Fluid Composition أو ممكن يكون
+
+415
+00:29:46,040 --> 00:29:50,700
+عندي مشكلة في المصنع وهو الـ Testis بس لأ ممكن
+
+416
+00:29:50,700 --> 00:29:54,780
+يكون عندي مشكلة أيضا في القنوات الناقلة من المصنع
+
+417
+00:29:54,780 --> 00:29:59,080
+إلى الـ إلى الـ إلى خلّيني أسميه الـ
+
+418
+00:30:02,470 --> 00:30:05,710
+النبيب القاذف خلّيني أسميها بهذا الشكل فبالتالي
+
+419
+00:30:05,710 --> 00:30:10,510
+في عندي مرحلة التصنيع مرحلة النقل والمنتج المنتج
+
+420
+00:30:10,510 --> 00:30:13,330
+هو عبارة عن الـ Seminal Fluid ممكن يكون عندي مشكلة
+
+421
+00:30:13,330 --> 00:30:16,770
+في مرحلة التصنيع في المصنع في المصنع هو ال testes
+
+422
+00:30:16,770 --> 00:30:20,890
+ممكن يكون عندي مشكلة في ال vas deferens وهو 
+
+423
+00:30:20,890 --> 00:30:24,570
+الأنابيب الناقلة وممكن يكون عندي مشكلة في العينة
+
+424
+00:30:24,570 --> 00:30:29,570
+يعني كل ما سبق طبيعي ولكن المشكلة في العينة بمعنى
+
+425
+00:30:29,570 --> 00:30:35,090
+بآخر إن العينة ما فيها sperm أو العينة فيها sperm 
+
+426
+00:30:35,090 --> 00:30:38,670
+ولكن عدده قليل أو العينة فيها sperm وعدده 100%
+
+427
+00:30:38,670 --> 00:30:42,170
+ولكن non-functional غير قادر على الإنجاب أو غير
+
+428
+00:30:42,170 --> 00:30:45,910
+قادر على التلقيح هي المقصود فيه فبالتالي ال
+
+429
+00:30:45,910 --> 00:30:51,810
+problem with the sperm ال problem with the sperm خلّيني
+
+430
+00:30:51,810 --> 00:30:56,750
+أقول إن الأسباب المرتبطة بالعقم عند الرجال لها
+
+431
+00:30:56,750 --> 00:31:02,790
+عدة أسباب، لو أنا بتاخد على مستوى ال testes فيه أسباب
+
+432
+00:31:02,790 --> 00:31:05,770
+على مستوى ال vas deferens و الأنابيب الناقلة
+
+433
+00:31:05,770 --> 00:31:09,970
+فيه أسباب و عوامل على مستوى العينة بحد ذاتها فيه
+
+434
+00:31:09,970 --> 00:31:15,130
+أسباب و عوامل أيضا ولكن بشكل عام أن عندي some men
+
+435
+00:31:15,130 --> 00:31:19,950
+produce no sperm فبسميه azoospermia زي ما حكينا في
+
+436
+00:31:19,950 --> 00:31:25,350
+ال slide ما قبل الأخيرة المحاضرة السابقة أو some male
+
+437
+00:31:25,350 --> 00:31:29,950
+produce seminal fluid with a few number of sperm
+
+438
+00:31:29,950 --> 00:31:34,050
+بنسميها oligospermia العينة ككل بنسميها seminal
+
+439
+00:31:34,050 --> 00:31:38,930
+fluid ال sperm ال بالداخل إذا كان طبيعي بنسميه
+
+440
+00:31:38,930 --> 00:31:43,250
+normal seminal fluid طبعا إذا كان طبيعي من حياته
+
+441
+00:31:43,250 --> 00:31:47,970
+العدد من حياته الحركة من حياته الحجم ومن حياته ال
+
+442
+00:31:47,970 --> 00:31:51,070
+progressive motility اللي هتكلم عنها بشكلها الأوضح
+
+443
+00:31:51,070 --> 00:31:55,780
+ولكن إذا كان عدد الحيوانات المنوية في العينة أقل من
+
+444
+00:31:55,780 --> 00:32:02,340
+20 مليون بسميها Oligospermia بسميها Oligospermia
+
+445
+00:32:02,340 --> 00:32:06,380
+طيب other problems include في عندي sexual
+
+446
+00:32:06,380 --> 00:32:11,020
+dysfunction عندي مشاكل في الأعضاء التناسلية الخاصة
+
+447
+00:32:11,020 --> 00:32:14,440
+بالذكر فبالتالي ما بتقوم بالوظيفة المطلوبة منه
+
+448
+00:32:14,440 --> 00:32:18,420
+ومنها في عندي hormonal and endocrine abnormality
+
+449
+00:32:18,420 --> 00:32:23,570
+مثلا عندي مشكلة في ال FSH عندي مشكلة في ال LH عندي
+
+450
+00:32:23,570 --> 00:32:27,330
+مشكلة في ال Testosterone لأنه هو الهرمون الذكوري
+
+451
+00:32:27,330 --> 00:32:30,470
+الموجود عند الذكور و ال Progesterone هو الهرمون
+
+452
+00:32:30,470 --> 00:32:34,950
+الأنثوي الموجود عند الإناث فبالتالي لو كان عندي
+
+453
+00:32:34,950 --> 00:32:38,390
+مشكلة في ال FSH و ال LH و ال Testosterone معناه
+
+454
+00:32:38,390 --> 00:32:42,370
+مشكلة عندي في عملية الإنتاج Infection صار عند هذا
+
+455
+00:32:42,370 --> 00:32:45,710
+ال male Infection في ال testes أو Infection في ال
+
+456
+00:32:45,710 --> 00:32:50,690
+accessory glands أو حاجة نسموها الغدد المساعدة
+
+457
+00:32:50,750 --> 00:32:54,210
+فبالتالي مش هينتج حيوانات منوية بالشكل المطلوب و
+
+458
+00:32:54,210 --> 00:32:57,530
+بالكم المطلوب و بالكفاءة المطلوبة Congenital
+
+459
+00:32:57,530 --> 00:33:02,290
+problems like pear defects such as the absence of
+
+460
+00:33:02,290 --> 00:33:05,130
+tubules that carry the sperm و هي ال vas
+
+461
+00:33:05,130 --> 00:33:09,430
+deferens بعض الذكور بيولدوا عندهم مشكلة في ال
+
+462
+00:33:09,430 --> 00:33:12,390
+vas deferens و هو القنوات الناقلة أو الوعاء
+
+463
+00:33:12,390 --> 00:33:17,470
+الناقل مفقود فبالتالي المصنع شغال و يخلق ولكن مافي
+
+464
+00:33:17,470 --> 00:33:22,400
+شيء ينقل من الداخل للخارج طبعا هدولة يعتبروا
+
+465
+00:33:22,400 --> 00:33:27,180
+infertile .. infertile غير قادر على الإنجاب بشكل طبيعي
+
+466
+00:33:27,180 --> 00:33:32,500
+ولكن لو أنا روحت عملت له حاجة بتسميها تيسا أو بيسا
+
+467
+00:33:32,500 --> 00:33:36,440
+يكون .. ممكن يكون قادر على الإنجاب طبعا شو التيسا و شو
+
+468
+00:33:36,440 --> 00:33:41,740
+البيسا هتكلم عنها في محاضرات لاحقة إن شاء الله
+
+469
+00:33:41,740 --> 00:33:47,400
+ببساطة تعريفة أنا باخد عينة أو خزعة من ال testes
+
+470
+00:33:47,400 --> 00:33:52,570
+نفسه Genetic Chromosomal Abnormality من الأسباب
+
+471
+00:33:52,570 --> 00:33:56,910
+التي قد تؤدي إلى male Infertility بعض الأسباب
+
+472
+00:33:56,910 --> 00:34:00,910
+والمشاكل التي لها علاقة بالكروموسوم أو بعض المشاكل
+
+473
+00:34:00,910 --> 00:34:05,250
+الجينية Anti-Sperm Antibodies حكينا أن male يمكن
+
+474
+00:34:05,250 --> 00:34:08,710
+يكون Anti-Sperm Antibodies  صحيح ضد نفسه إذا اتعرض
+
+475
+00:34:08,710 --> 00:34:12,410
+لترومة في منطقة ال Reproductive System
+
+476
+00:34:12,410 --> 00:34:16,510
+ال Varicocele الدوالي وهي عبارة عن انتفاخات في
+
+477
+00:34:16,510 --> 00:34:20,200
+الأوعية الدموية الموصلة للدم والغذاء الى ال
+
+478
+00:34:20,200 --> 00:34:24,280
+testes فبتصير عندي Varicocele تؤدي الى تأخر الإنجاب
+
+479
+00:34:24,280 --> 00:34:27,460
+يعني تؤدي الى infertility لها علاج صحيح لها علاج
+
+480
+00:34:27,460 --> 00:34:30,760
+ال lifestyle ممكن تأثر على ال number و ال quality
+
+481
+00:34:30,760 --> 00:34:35,300
+تبع ال sperm ال lifestyle يعني تتحدث عنها بلا حرج
+
+482
+00:34:35,300 --> 00:34:42,020
+زي التدخين زي الدخان و الشيشة و العمل في مصنع
+
+483
+00:34:42,020 --> 00:34:45,360
+البطاريات العمل في مصانع ال sponges التعرض لدرجات
+
+484
+00:34:45,360 --> 00:34:49,300
+حرارة عالية لفترة وقت زمنية طويلة التعرض للفسفور
+
+485
+00:34:49,300 --> 00:34:55,560
+الأبيض وخلافه الالكحول and drugs ممكن تسبب
+
+486
+00:34:55,560 --> 00:34:59,000
+abnormality وممكن في ال semen parameters أو ممكن
+
+487
+00:34:59,000 --> 00:35:02,700
+تؤدي إلى reduction في ال seminal quality أو في ال
+
+488
+00:35:02,700 --> 00:35:06,440
+sperm quality بشكل مؤقت لأن ال cigarette smoking
+
+489
+00:35:06,440 --> 00:35:09,640
+تأثيره عند ال male يختلف عن تأثيره عند ال female
+
+490
+00:35:09,640 --> 00:35:13,560
+ولكن اللي بدأنا نعرفه أن الالكحول و ال cigarette
+
+491
+00:35:13,560 --> 00:35:16,920
+smoking في الغالب تأثيره بكون temporary عند ال
+
+492
+00:35:16,920 --> 00:35:23,790
+male لأن ال seminal fluid أو ال sperm ما بيخزن
+
+493
+00:35:23,790 --> 00:35:27,630
+لفترات زمنية طويلة جدا لأ هو في حالة تخليق بشكل
+
+494
+00:35:27,630 --> 00:35:31,070
+مستمر فلو أتوقف الإنسان عن شرب الكحول أو عن تناول
+
+495
+00:35:31,070 --> 00:35:35,010
+التدخين برجع الأمر لوضعه الطبيعي ولكن بعد فترة
+
+496
+00:35:35,010 --> 00:35:40,330
+زمنية معينة ال environmental toxins المتعرض لها خاصة
+
+497
+00:35:40,330 --> 00:35:46,590
+ال pesticides والمواد الثقيلة والمواد الإشعاعية بعض
+
+498
+00:35:46,590 --> 00:35:50,570
+الأحيان بيصنف بعض الحالات unexplained infertility
+
+499
+00:35:50,570 --> 00:35:54,310
+idiopathic يعني كله طبيعي مية في المية الإنتاج مية
+
+500
+00:35:54,310 --> 00:35:55,910
+في المية الهرمونات مية في المية ال reproductive
+
+501
+00:35:55,910 --> 00:35:58,630
+system مية في المية مافي عنده antifertility body
+
+502
+00:35:58,630 --> 00:36:02,230
+مافي عنده ال varicocele lifestyle مية في المية مافي
+
+503
+00:36:02,230 --> 00:36:05,490
+عنده مشكلة ولكن والجينات برضه مافي عنده مشكلة
+
+504
+00:36:05,490 --> 00:36:09,570
+جينية أو مافي عنده مشكلة جينية ولكن يصنف infertile
+
+505
+00:36:09,570 --> 00:36:15,200
+تحت عنوان idiopathic infertility أو unexplained
+
+506
+00:36:15,200 --> 00:36:19,720
+Infertility يعني أسباب غير معروفة طبعا عندي
+
+507
+00:36:19,720 --> 00:36:24,280
+بالنسبة لل infertility cases .. causes عندي 30%
+
+508
+00:36:24,280 --> 00:36:28,660
+اللي لها علاقة بال male عندي 30% اللي لها علاقة بال
+
+509
+00:36:28,660 --> 00:36:32,560
+female عندي 10% اللي لهم علاقة بال male و female
+
+510
+00:36:32,560 --> 00:36:38,480
+25% تعتبر idiopathic و 5% غير معروفين حتى مش
+
+511
+00:36:38,480 --> 00:36:42,740
+مصنفين ك idiopathic بدي أنا قبل ما أختم هذه
+
+512
+00:36:42,740 --> 00:36:46,850
+المحاضرة بدي أحكي ببساطة جدا أن كمية و نسبة ال
+
+513
+00:36:46,850 --> 00:36:51,330
+infertility في الواقع اللي بيعيش في قطاع غزة زادت
+
+514
+00:36:51,330 --> 00:36:57,210
+بعد حرب 2008 بشكل ملحوظ جدا بعد حرب 2012 and the
+
+515
+00:36:57,210 --> 00:37:00,510
+rate طبعا بعد حرب 2012 صار and the recurrent abortion
+
+516
+00:37:00,510 --> 00:37:06,870
+بشكل ملحوظ جدا خصوصا عند سكان المناطق الحدودية
+
+517
+00:37:06,870 --> 00:37:09,950
+سواء المناطق الشرقية أو المناطق الشمالية قد يكون
+
+518
+00:37:09,950 --> 00:37:14,440
+له علاقة وقد يكون .. وقد لا يكون له علاقة بمخلفات
+
+519
+00:37:14,440 --> 00:37:18,280
+الحروب هذا بيحتاج إلى دراسة ولكن ما تم لمسه على
+
+520
+00:37:18,280 --> 00:37:21,600
+أرض الواقع أن ال male infertility زادت بعد حرب
+
+521
+00:37:21,600 --> 00:37:26,540
+2008 و ال miscarriage أو ال recurrent abortion أو
+
+522
+00:37:26,540 --> 00:37:31,560
+التشوهات الجنينية التي تظهر على الأجنة بعد عملية
+
+523
+00:37:31,560 --> 00:37:34,800
+ال miscarriage أو بعد عملية ال abortion كانت عالية
+
+524
+00:37:34,800 --> 00:37:40,580
+بعد حرب 2012 في المناطق الحدودية الشرقية والشمالية
+
+525
+00:37:40,830 --> 00:37:44,530
+سوف نكتفي بهذا القدر في محاضرة اليوم، على أمل أن
+
+526
+00:37:44,530 --> 00:37:48,290
+نستكمل في المحاضرة التالية تحت عنوان Primary
+
+527
+00:37:48,290 --> 00:37:53,470
+Fertility and Secondary Infertility، دمتم في حفظ
+
+528
+00:37:53,470 --> 00:37:54,570
+الله وراعي حياتي
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/C8pUDf7Uze8_raw.json b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/C8pUDf7Uze8_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..d1c2c0a8c320dcfb3b5fdc934b714e7c21454d03
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/C8pUDf7Uze8_raw.json
@@ -0,0 +1 @@
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"start": 1463.75, "end": 1492.47, "text": "hyperthyroidism أو hypothyroidism سيدة عندها thyroid hormone activity عالي جدا بتسميها hyperthyroidism أو very low بتسميها hypothyroidism وهذا بيأثر بشكل كبير جدا على ال ovulation و ال menstrual cycle عشان كده أي سيدة .. خدوا بالكوا .. أي سيدة بتروح تعمل إجزي تلقيح صناعي أو حق المجهري بيقصولها هرمونات ال FSH و ال LH و ال E2", "tokens": [3495, 610, 28433, 6490, 1434, 34051, 7420, 18907, 6490, 1434, 8608, 25708, 3660, 43242, 11296, 32332, 24211, 5191, 6225, 6027, 1829, 10874, 28259, 39894, 38251, 1829, 11296, 9848, 28433, 6490, 1434, 34051, 588, 2295, 39894, 38251, 1829, 11296, 7420, 18907, 6490, 1434, 37037, 15730, 4724, 1829, 10721, 49115, 4724, 8592, 28820, 9122, 3555, 13546, 10874, 28259, 15844, 2423, 14187, 2776, 4032, 2423, 38827, 304, 6586, 6225, 8592, 7649, 9122, 3215, 3224, 36632, 8608, 25708, 3660, 4386, 16490, 3215, 14407, 20666, 4117, 14407, 4386, 36632, 8608, 25708, 3660, 39894, 32887, 5016, 6055, 25957, 1211, 11933, 7435, 11622, 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"temperature": 1.0}, {"id": 82, "seek": 227457, "start": 2260.83, "end": 2274.57, "text": "سوف نكتفي بهذا القدر في محاضرة اليوم، على أمل أن نستكمل في المحاضرة التالية تحت عنوان Primary Fertility and Secondary Infertility، دمتم في حفظ الله ورياه حياتي", "tokens": [3794, 38688, 8717, 4117, 2655, 41185, 39627, 15730, 25062, 3215, 2288, 8978, 3714, 5016, 46958, 25720, 45595, 20498, 12399, 15844, 5551, 42213, 14739, 8717, 14851, 24793, 1211, 8978, 9673, 5016, 46958, 25720, 16712, 6027, 10632, 6055, 33753, 18871, 2407, 7649, 42576, 479, 911, 1140, 293, 5736, 822, 682, 34784, 1140, 12399, 11778, 2304, 39237, 8978, 11331, 5172, 19913, 21984, 4032, 2288, 25528, 3224, 11331, 1829, 9307, 1829], "avg_logprob": -0.19450826482737765, "compression_ratio": 1.4375, "no_speech_prob": 4.172325134277344e-07, "words": [{"start": 2260.83, "end": 2261.15, "word": "سوف", "probability": 0.962890625}, {"start": 2261.15, "end": 2261.59, "word": " نكتفي", "probability": 0.7611083984375}, {"start": 2261.59, "end": 2261.95, "word": " بهذا", "probability": 0.947509765625}, {"start": 2261.95, "end": 2262.31, "word": " القدر", "probability": 0.9892578125}, {"start": 2262.31, "end": 2262.41, "word": " في", "probability": 0.96435546875}, {"start": 2262.41, "end": 2262.87, "word": " محاضرة", "probability": 0.9764404296875}, {"start": 2262.87, "end": 2263.67, "word": " اليوم،", "probability": 0.80029296875}, {"start": 2263.67, "end": 2263.85, "word": " على", "probability": 0.89208984375}, {"start": 2263.85, "end": 2264.29, "word": " أمل", "probability": 0.916015625}, {"start": 2264.29, "end": 2264.53, "word": " أن", "probability": 0.9423828125}, {"start": 2264.53, "end": 2265.09, "word": " نستكمل", "probability": 0.972900390625}, {"start": 2265.09, "end": 2265.21, "word": " في", "probability": 0.9609375}, {"start": 2265.21, "end": 2265.83, "word": " المحاضرة", "probability": 0.99169921875}, {"start": 2265.83, "end": 2266.79, "word": " التالية", "probability": 0.9951171875}, {"start": 2266.79, "end": 2267.39, "word": " تحت", "probability": 0.954833984375}, {"start": 2267.39, "end": 2267.81, "word": " عنوان", "probability": 0.7936197916666666}, {"start": 2267.81, "end": 2268.29, "word": " Primary", "probability": 0.552734375}, {"start": 2268.29, "end": 2269.17, "word": " Fertility", "probability": 0.798583984375}, {"start": 2269.17, "end": 2269.75, "word": " and", "probability": 0.71826171875}, {"start": 2269.75, "end": 2270.55, "word": " Secondary", "probability": 0.92919921875}, {"start": 2270.55, "end": 2272.33, "word": " Infertility،", "probability": 0.8990478515625}, {"start": 2272.33, "end": 2272.79, "word": " دمتم", "probability": 0.60302734375}, {"start": 2272.79, "end": 2273.13, "word": " في", "probability": 0.9755859375}, {"start": 2273.13, "end": 2273.47, "word": " حفظ", "probability": 0.99609375}, {"start": 2273.47, "end": 2273.77, "word": " الله", "probability": 0.89501953125}, {"start": 2273.77, "end": 2274.31, "word": " ورياه", "probability": 0.5455322265625}, {"start": 2274.31, "end": 2274.57, "word": " حياتي", "probability": 0.739990234375}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2314.0078125, "duration_after_vad": 2248.070624999993}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/C8pUDf7Uze8_raw.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/C8pUDf7Uze8_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..9126603c8c24520059c04200a35727387e9afd37
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/C8pUDf7Uze8_raw.srt
@@ -0,0 +1,2112 @@
+1
+00:00:01,250 --> 00:00:05,090
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:05,090 --> 00:00:09,750
+المرسلين سيدنا محمد الصادق الأمين أما بعد بداية
+
+3
+00:00:09,750 --> 00:00:14,970
+نرحب بكم في مصاف مواضيع خاصة في العلوم الطبية
+
+4
+00:00:14,970 --> 00:00:19,980
+المخبرية لطلبة الماجستير المستوى الثانياتحدثنا في
+
+5
+00:00:19,980 --> 00:00:25,200
+اللقاء التعريفي عن محتويات هذا المصدق وقد أسلفنا
+
+6
+00:00:25,200 --> 00:00:29,840
+أن هذا المصدق سوف يتحدث عن تقنية مهمة جدا وهي
+
+7
+00:00:29,840 --> 00:00:33,580
+تقنية التلقيح الصناعي أو أطفال الأنابيب أو ما
+
+8
+00:00:33,580 --> 00:00:38,380
+يُعرف حاليا بالحقن المجهري حكينا إن هناك تلت طرق
+
+9
+00:00:38,380 --> 00:00:44,160
+مختلفة هي عبارة عن عملية التلقيح الصناعي أو أطفال
+
+10
+00:00:44,160 --> 00:00:47,970
+الأنابيب وهي عبارة عن الطريقة التقليديةثم ارتقت
+
+11
+00:00:47,970 --> 00:00:52,390
+فيما بعد إلى الحقن المجهري الذي يُعرف باختصار IGC
+
+12
+00:00:52,390 --> 00:00:57,590
+أي Intracytoplasmic sperm injection تكلمنا في
+
+13
+00:00:57,590 --> 00:01:01,670
+البداية عن محتوى هذا المصاق ما على الطلاب من
+
+14
+00:01:01,670 --> 00:01:06,070
+واجبات وما على المدرس من التزامات وواجبات أيضا
+
+15
+00:01:06,070 --> 00:01:10,950
+توقفنا عن أسباب ال IGC واليوم سنستكمل هذا الموضوع
+
+16
+00:01:10,950 --> 00:01:15,520
+حول مصطلح مهم جدا وهو ال infertilityال infertility
+
+17
+00:01:15,520 --> 00:01:20,600
+ككلمة تعني عدم القدرة على الإنجاب فال infertility
+
+18
+00:01:20,600 --> 00:01:26,500
+ككلمة بشكلها العام و شكلها المعروف هي عدم قدرة
+
+19
+00:01:26,500 --> 00:01:31,040
+الزوجين على الحصول على طفل خلال فترة زمنية معينة
+
+20
+00:01:31,040 --> 00:01:35,480
+ولكن للأسف في مجتمعنا الحالي أو مجتمعنا المتواجد
+
+21
+00:01:35,480 --> 00:01:40,220
+الآن هناك اختلاف في المعنى ما بين العقوم و عدم
+
+22
+00:01:40,220 --> 00:01:44,020
+القدرة على الإنجابواسلفنا فيما سبق إن العكم هو
+
+23
+00:01:44,020 --> 00:01:48,420
+الـsterility وعدم القدرة على الإنجاب بأي شكل من
+
+24
+00:01:48,420 --> 00:01:53,480
+الأشكال أما ال infertility وهي عبارة عن مشكلة
+
+25
+00:01:53,480 --> 00:01:58,640
+يواجهها بعض الناس أو بعض العائلات هي عبارة عن تأخر
+
+26
+00:01:58,640 --> 00:02:02,380
+الإنجاب أو عدم القدرة على الإنجاب بالطريقة
+
+27
+00:02:02,380 --> 00:02:06,120
+التخلدية وللأسف، بناء على العادات والتقاليد
+
+28
+00:02:06,120 --> 00:02:09,860
+الموجودة في مجتمعنادائما أي two couples تبدو حياة
+
+29
+00:02:09,860 --> 00:02:14,620
+جديدة متى سوف يتم الإنجاب وينتأخر الإنجاب لفترة
+
+30
+00:02:14,620 --> 00:02:18,940
+زمنية بسيطة تقدر بشهور و لو خمسة شهور أو ستة شهور
+
+31
+00:02:18,940 --> 00:02:24,100
+أو سنة يصنفهم المجتمع يصنفه على إنه infertile أو
+
+32
+00:02:24,100 --> 00:02:28,000
+غير قادر على الإنجاب طبعا هذا مصطلح خاطئ جدا
+
+33
+00:02:28,000 --> 00:02:33,320
+وتصنيف خاطئ جدا التعريف العلمي لل infertility هي
+
+34
+00:02:33,320 --> 00:02:38,170
+عبارة عن عدم القدرة على الإنجاب بشرطفي فترة زمانية
+
+35
+00:02:38,170 --> 00:02:45,290
+تقدر بسنة واحدة من بعد الزواج بشرط أن يكون هناك
+
+36
+00:02:45,290 --> 00:02:52,610
+نية للإنجاب بشكل مستمر علشان كده يُعرف بإنه يُعرف
+
+37
+00:02:52,610 --> 00:02:56,150
+هذا المصطلح بإنه usually defined as inability to
+
+38
+00:02:56,150 --> 00:03:01,010
+get pregnant after trying for one year of regular
+
+39
+00:03:01,010 --> 00:03:05,010
+sexual intercourse without any contraceptive يعني
+
+40
+00:03:05,010 --> 00:03:08,910
+في عندك two couplesعندهم الرغبة في الإنجاب و
+
+41
+00:03:08,910 --> 00:03:13,970
+بيحاولوا .. و بيحاولوا بيسعوا في الإنجاب للحصول
+
+42
+00:03:13,970 --> 00:03:16,670
+على طفل سواء كان طبعا male أو female بغض النظر عن
+
+43
+00:03:16,670 --> 00:03:20,810
+جنس المولود حاليا ولكن لا يملكوا القدرة خلال هذه
+
+44
+00:03:20,810 --> 00:03:23,910
+السنة إذا فقدوا القدرة على الإنجاب بنسميهم
+
+45
+00:03:23,910 --> 00:03:29,090
+infertile طب هل ال infertility تعتبر مشكلة؟ وهل
+
+46
+00:03:29,090 --> 00:03:33,920
+تصنف بناء على التصنيفات الألمية مشكلة؟صحيح تعتبر
+
+47
+00:03:33,920 --> 00:03:37,300
+من أكتر المشاكل الانتشارة سواء كان في المجتمع
+
+48
+00:03:37,300 --> 00:03:41,980
+الغربي أو المجتمع العربي أو الشرقي رغم كثافة
+
+49
+00:03:41,980 --> 00:03:46,760
+السكانية الموجودة زيها زي السمنة زيها زي الـ
+
+50
+00:03:46,760 --> 00:03:52,100
+Diabetes زيها زي blood pressure تصنف كحالة مرضية
+
+51
+00:03:52,100 --> 00:03:57,860
+حوالين العالم تقدر ال infertility بحوالي 8 إلى 12%
+
+52
+00:03:57,860 --> 00:04:00,790
+between two couples يعني عندي لو أنا عنديmeat
+
+53
+00:04:00,790 --> 00:04:06,690
+couples منهم 12% يصنفوا على إنهم infertile على
+
+54
+00:04:06,690 --> 00:04:09,670
+سبيل المثال في ال united states كانت النسبة أعلى
+
+55
+00:04:09,670 --> 00:04:13,530
+تصل إلى 15% يعني لو أنا عنده meat couples بطلّق
+
+56
+00:04:13,530 --> 00:04:18,250
+منهم 15 couples infertile ولو توجهنا إلى المجتمعات
+
+57
+00:04:18,250 --> 00:04:23,570
+الغربية هنلاقي كنسبة بتزيد يعني على سبيل المثال
+
+58
+00:04:23,570 --> 00:04:27,190
+ألمانيا بلاقي نسبة ال infertility عالية جدا و ال
+
+59
+00:04:27,190 --> 00:04:32,300
+infertility دي مش سببها أمورطبية، ولكن فقدان الـ
+
+60
+00:04:32,300 --> 00:04:36,540
+two couples الرغبة في اقتناء طفل أو امتلاك طفل أو
+
+61
+00:04:36,540 --> 00:04:40,780
+الحصول على طفل طبيعة مجتمع، طبيعة عاداته تقاليد في
+
+62
+00:04:40,780 --> 00:04:45,440
+ال United States حوالي 15 أو 10% من السيدات اللي
+
+63
+00:04:45,440 --> 00:04:52,020
+عمهم يتروح ما بين 15 إلى 44 سنة يصنفوا بعدم القدرة
+
+64
+00:04:52,020 --> 00:04:56,900
+على الإنجاب بشكل طبيعي أو عدم القدرة على الاحتفاظ
+
+65
+00:04:56,900 --> 00:05:01,200
+بالجنين بشكله الطبيعيليش صنف الخمستعش لأربع
+
+66
+00:05:01,200 --> 00:05:04,540
+واربعين سنة؟ لأن الخمستعش و الأربع و أربعين سنة
+
+67
+00:05:04,540 --> 00:05:08,680
+العمر الواقع ما بينهم يعتبر هو سن الإنجاب عند
+
+68
+00:05:08,680 --> 00:05:13,900
+السيدة فحوالي من كل ميت سيدة عمرها خمستعش إلى أربع
+
+69
+00:05:13,900 --> 00:05:18,020
+واربعين سنة بطلّها منهم عشر سيدات تفقد القدرة على
+
+70
+00:05:18,020 --> 00:05:22,360
+الاحتفاظ بالجنين غير قادرة على الإنجاب بشكل طبيعي
+
+71
+00:05:22,360 --> 00:05:28,820
+وتصنف بأنها infertileبأنها infertile، هذا التعريف
+
+72
+00:05:28,820 --> 00:05:32,680
+الأساسي هل هناك تعريف أخر لل infertility؟ أكيد
+
+73
+00:05:32,680 --> 00:05:36,020
+هناك تعريف أخر ل infertility فعلى سبيل المثال لو
+
+74
+00:05:36,020 --> 00:05:39,120
+أنا عرفت ال infertility according to reproductive
+
+75
+00:05:39,120 --> 00:05:42,940
+age يعني بمناعة اخر أنا بدي أصنف ال infertility
+
+76
+00:05:42,940 --> 00:05:46,660
+بناء على العمر الإنجابي، طبعا ال male له عمر
+
+77
+00:05:46,660 --> 00:05:51,100
+إنجابي يختلف عن ال femaleالمال عمر الإنجابي من 16
+
+78
+00:05:51,100 --> 00:05:57,480
+حوالي ل 60 أو ل 50 طبعا زيادة العمر هيأثر على ال
+
+79
+00:05:57,480 --> 00:06:01,320
+ability of production عند المال بينما ال female ال
+
+80
+00:06:01,320 --> 00:06:06,160
+reproductive age محدود يقدر من على سبيل المثال من
+
+81
+00:06:06,160 --> 00:06:11,720
+مجتمع لمجتمع يختلف من 15 سنة ل 35 سنة ل 40 سنة
+
+82
+00:06:11,720 --> 00:06:16,190
+ماكسما هذا عبارة عن العمر الإنجابي عند السيدةطب
+
+83
+00:06:16,190 --> 00:06:18,830
+العمر الإنجابي عند ال male أطول؟ أكيد أطول وحنا
+
+84
+00:06:18,830 --> 00:06:22,990
+نعرف السبب كمان شوية إذا لو أنا قسمت ال
+
+85
+00:06:22,990 --> 00:06:26,170
+infertility أو عرفت ال infertility بتعريف آخر بناء
+
+86
+00:06:26,170 --> 00:06:30,410
+على ال reproductive age هو عدم قدرة ال two couples
+
+87
+00:06:30,410 --> 00:06:34,930
+على الإنجاب أو على الحصول على طفل خلال الفترة
+
+88
+00:06:34,930 --> 00:06:39,970
+الإنجابية التي تتروح من 15 ل 49 سنة إذا اندمجت ال
+
+89
+00:06:39,970 --> 00:06:43,230
+male مع ال female to become or remain pregnant
+
+90
+00:06:43,610 --> 00:06:46,970
+within five years of exposure to pregnancy يعني
+
+91
+00:06:46,970 --> 00:06:52,750
+أنا عندي سيدات عمرهم يتروح من 15 إلى 49 سنة فقدوا
+
+92
+00:06:52,750 --> 00:06:57,410
+القدرة على الإنجاب لمدة خمس سنوات متتالية رغم
+
+93
+00:06:57,410 --> 00:07:00,850
+المحاولة
+
+94
+00:07:00,850 --> 00:07:06,290
+المستمرة من أجل إنجاب طفل بسميها infertile تعريف
+
+95
+00:07:06,290 --> 00:07:10,370
+آخر بسمي inability to become pregnant with live
+
+96
+00:07:10,370 --> 00:07:14,780
+pairs within five years of exposurebased on
+
+97
+00:07:14,780 --> 00:07:19,100
+constant unique status بمعنى آخر إن هذه ال women
+
+98
+00:07:19,100 --> 00:07:25,780
+تفقد القدرة على الإنجاب خلال خمس سنوات من المحاولة
+
+99
+00:07:25,780 --> 00:07:29,720
+على الإنجاب ولكن هنا صنف ال infertility كأنها
+
+100
+00:07:29,720 --> 00:07:34,000
+infertility ليس فقط القدرة على الحمل فقط ولكن
+
+101
+00:07:34,000 --> 00:07:38,620
+القدرة على الحصول life baby life birth يعني سيدة
+
+102
+00:07:38,620 --> 00:07:44,900
+تحمل وتحصل على طفل حيعلى قيد الحياة، يعني تصل
+
+103
+00:07:44,900 --> 00:07:49,240
+لمرحلة الولادة، فهذا تعريف آخر لل infertility بشرط
+
+104
+00:07:49,240 --> 00:07:53,960
+.. بشرط أن هذه السيدة تكون مازالت محافظة على
+
+105
+00:07:53,960 --> 00:07:59,560
+الرغبة في الإنجاب غير مرضعة ولا تتناول موانع حمل،
+
+106
+00:07:59,560 --> 00:08:02,880
+بنسميها oral contraception طب ليه السمة أو ليش
+
+107
+00:08:02,880 --> 00:08:07,690
+حافظة على تلت معايير الأساسية؟إن السيدة ما زالت
+
+108
+00:08:07,690 --> 00:08:11,170
+تملك القدرة على الإنجاب لإن هذه الأمور لها علاقة
+
+109
+00:08:11,170 --> 00:08:14,710
+بالأمور النفسية كمان شوية هنتعرف إن الأمور النفسية
+
+110
+00:08:14,710 --> 00:08:16,950
+و ال depression اللي بتعرض إليها ال male و ال
+
+111
+00:08:16,950 --> 00:08:20,870
+female يعمل على إنقاس القدرة على الإنجاب No
+
+112
+00:08:20,870 --> 00:08:25,130
+lactation أو lacting لإن عملية الإرضاع للطفل تؤدي
+
+113
+00:08:25,130 --> 00:08:28,690
+إلى تأخير عملية ال ovulation فبالتالي تؤدي إلى
+
+114
+00:08:28,690 --> 00:08:32,950
+تأخير عملية الإنجاب لإن ما بنعرف إن هرمون الحليب
+
+115
+00:08:33,760 --> 00:08:38,380
+الـ LH يؤثر على الدورة الخاصة بالسيدة، مما يؤدي
+
+116
+00:08:38,380 --> 00:08:42,040
+إلى تأخير عملية الإبادة، مما يؤدي إلى تأخير الحمض
+
+117
+00:08:42,040 --> 00:08:45,020
+السبب التالت هو الـ oral contraceptive الممكن
+
+118
+00:08:45,020 --> 00:08:49,160
+تتناول السيدة من أجل منع عملية الحمض فبالتالي،
+
+119
+00:08:49,160 --> 00:08:54,020
+السيدة حافظة على الرغبة على الإنجاب لم تتناول
+
+120
+00:08:54,020 --> 00:08:58,960
+موانع حمض وغير مرضعة، ولكنها غير قادرة على الإنجاب
+
+121
+00:08:58,960 --> 00:09:05,000
+أو الحصول على طفل حي، مولود حييعني بتحصل على جنين
+
+122
+00:09:05,000 --> 00:09:11,080
+حي بعد 9 شهور لمدة خمس سنوات متواصلة يمكن أن تصنف
+
+123
+00:09:11,080 --> 00:09:16,620
+بأنها infertile ما هي أسباب ال infertility عند ال
+
+124
+00:09:16,620 --> 00:09:19,940
+male وما هي أسباب ال infertility عند ال female؟
+
+125
+00:09:19,940 --> 00:09:24,140
+وهل هناك أسباب مختلفة أو أسباب متشابهة؟ أكيد تبع
+
+126
+00:09:24,140 --> 00:09:29,450
+الجنس و ال reproductive age هناك أسباب مختلفةسنبدأ
+
+127
+00:09:29,450 --> 00:09:33,030
+بأسباب ال infertility عند الفيميل وأولهم هيعرف اسم
+
+128
+00:09:33,030 --> 00:09:36,970
+tubular blockage كلمنا في المحاضرة السابقة إن ال
+
+129
+00:09:36,970 --> 00:09:41,070
+reproductive system عند الفيميل بيبدأ بالcervix،
+
+130
+00:09:41,070 --> 00:09:44,290
+بعدين الرحم أو عنق الرحم خلّيني أسميه، بعدين
+
+131
+00:09:44,290 --> 00:09:48,610
+الرحم، بعدين قنوات فلوك، بعدين المبيض هذا هو عبارة
+
+132
+00:09:48,610 --> 00:09:51,690
+عن ال reproductive system عند السيدة أي مشكلة في
+
+133
+00:09:51,690 --> 00:09:56,370
+أي منطقة من تلك المناطق يودي إلى حدوث infertility
+
+134
+00:09:56,660 --> 00:10:02,420
+قد تكون دائمة و قد تكون مؤقتة تحل بالإلاج قد يكون
+
+135
+00:10:02,420 --> 00:10:06,240
+إلاج عن طريق medication و قد يكون إلاج يستوجب
+
+136
+00:10:06,240 --> 00:10:09,640
+الجراحة سنتحدث عن هذا الموضوع أول سبب من أسباب ال
+
+137
+00:10:09,640 --> 00:10:13,300
+infertility هو عبارة عن انغلاق في الأنابيب أي
+
+138
+00:10:13,300 --> 00:10:18,820
+أنابيب أشهرها الفانوبيا نتيوب أول سبب من الأسباب
+
+139
+00:10:18,820 --> 00:10:23,180
+التي تؤدي إلى تأخر الإنجاب عند السيدة هي انغلاق
+
+140
+00:10:23,180 --> 00:10:27,990
+الأنابيب انغلاق الأنابيبشو بيعمل؟ ببساطة جدا أول
+
+141
+00:10:27,990 --> 00:10:32,550
+شغلة بشكل طلقائي يمنع وصول ال sperm إلى ال oocyte
+
+142
+00:10:32,550 --> 00:10:37,310
+لإن ال oocyte وهي البويضة إذا كانت ناضجة تلقح في
+
+143
+00:10:37,310 --> 00:10:42,010
+الفلوبيا نتيوب ولكي يتم التلقيح في الفلوبيا نتيوب
+
+144
+00:10:42,010 --> 00:10:46,230
+يجب على ال sperm أن يقطع منطقة عنق الرحم والرحم
+
+145
+00:10:46,230 --> 00:10:49,750
+ليصل إلى الفلوبيا نتيوب ويلقح البويضة في هذا
+
+146
+00:10:49,750 --> 00:10:53,930
+المكان فإذا صار عندى blockage في الفلوبيا نتيوب
+
+147
+00:10:53,930 --> 00:10:57,890
+أدبنها ال sperm أن يصللـ Targeted Place اللي موجود
+
+148
+00:10:57,890 --> 00:11:01,870
+فيها البويضة فبالتالي مش هيصير عملية التلقيح إذن
+
+149
+00:11:01,870 --> 00:11:07,690
+أول شغلة أن الـ Tepular Blockage تمنا لـ Pregnancy
+
+150
+00:11:07,690 --> 00:11:12,490
+من خلال منع الستر من الوصول إلى البويضة و تلقيحها
+
+151
+00:11:12,490 --> 00:11:19,150
+أو من خلال منع وصول البويضة الملقحة إلى الرحم لأن
+
+152
+00:11:19,150 --> 00:11:23,370
+البويضة بعد ما تتلقح في ال Fallopian Tube المفروض
+
+153
+00:11:23,600 --> 00:11:26,780
+تسافر من الـ Fallopian tube حتى تصل إلى الرحم
+
+154
+00:11:26,780 --> 00:11:31,600
+وتنغرز في بطانة الرحم لتكوين الجنين اللي فيما بعد
+
+155
+00:11:31,600 --> 00:11:35,200
+يكوّن لـ Placenta أو لتكوين الـ Placenta التي تؤدي
+
+156
+00:11:35,200 --> 00:11:41,540
+إلى مصدر غذاء للجنين فعندي طريقتين أو two way للـ
+
+157
+00:11:41,540 --> 00:11:45,940
+tubular blockage التي تؤدي لمنع الحمض أول حاجة منع
+
+158
+00:11:45,940 --> 00:11:49,400
+وصول الحيوان المنو ال sperm إلى البويضة مما يمنع
+
+159
+00:11:49,400 --> 00:11:54,210
+التلقيح منعانتقال البويضة الملقحة من الـ Fallopian
+
+160
+00:11:54,210 --> 00:11:58,310
+tube إلى الرحم مما يؤدي إلى عدم تكوين الجنين
+
+161
+00:11:58,310 --> 00:12:02,410
+فبالتالي المحصلة سفر في الشيبرجنانسي السبب التاني
+
+162
+00:12:02,410 --> 00:12:05,950
+عند الفيميل حاجة بنتسميها Endometriosis ببساطة جدا
+
+163
+00:12:05,950 --> 00:12:09,270
+Endometriosis مصطلح من ال Endometrium و ال
+
+164
+00:12:09,270 --> 00:12:13,350
+Endometrium هي عبارة عن النسيج المبطن للرحم أو
+
+165
+00:12:13,350 --> 00:12:17,690
+بطانة الرحم بسموهافي بعض الأحيان وبعض الحالات
+
+166
+00:12:17,690 --> 00:12:21,690
+المرضية بيصير في عندي خلل في الأنسجة المبطنة للرحم
+
+167
+00:12:21,690 --> 00:12:25,410
+اللي بنسميها بطنط الرحم أو ال endometerium فبصير
+
+168
+00:12:25,410 --> 00:12:30,030
+إليها انتقال أو نمو خارج الرحم انتقال ال
+
+169
+00:12:30,030 --> 00:12:35,310
+endometerium ونموها خارج الرحم يؤدي إلى تكوين
+
+170
+00:12:35,310 --> 00:12:39,150
+pregnancy failure يؤدي إلى تكوين pregnancy failure
+
+171
+00:12:39,150 --> 00:12:43,800
+لأنه بيبنع عملية أصلا التبويضأو قد يمنع وصول
+
+172
+00:12:43,800 --> 00:12:48,320
+البوايضة الملقحة إلى المكان المناسب لتكوين الجنين
+
+173
+00:12:48,320 --> 00:12:51,560
+داخل الرحم السبب التالت بنسميه حاجة بنسميها
+
+174
+00:12:51,560 --> 00:12:55,600
+cervical factor cervical factor يعني عوامل لها
+
+175
+00:12:55,600 --> 00:13:00,520
+علاقة بأنق الرحم وأن أنق الرحم يعتبر أول محطات
+
+176
+00:13:00,520 --> 00:13:04,460
+انتقال ال sperm بعد ال .. بعد ال .. ال .. ال .. ال
+
+177
+00:13:04,460 --> 00:13:05,080
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+178
+00:13:05,080 --> 00:13:05,680
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+179
+00:13:05,680 --> 00:13:06,800
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+180
+00:13:06,800 --> 00:13:07,680
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+181
+00:13:07,680 --> 00:13:08,180
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+182
+00:13:08,180 --> 00:13:08,260
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+183
+00:13:08,260 --> 00:13:12,010
+.. ال .. ال .. ال .. ال .. ال .. ال .. الor
+
+184
+00:13:12,010 --> 00:13:15,130
+antagonist to sperm يعني في عندى في ال cervical
+
+185
+00:13:15,130 --> 00:13:20,190
+factor two factors الأول كمية الميوكاس الموجودة في
+
+186
+00:13:20,190 --> 00:13:26,130
+منطقة ال cervical كمية قليلة جدا هى أدلها way تمنع
+
+187
+00:13:26,130 --> 00:13:30,370
+حدوث ال pregnancy او الشيء التانى ان وجود في منطقة
+
+188
+00:13:30,370 --> 00:13:35,230
+ال cervical sperm يعمل ك antagonist يعني مضاد أو
+
+189
+00:13:35,230 --> 00:13:39,330
+مواد تستخدم او مواد موجودة عفوا مواد موجودة في
+
+190
+00:13:39,330 --> 00:13:42,650
+منطقة ال cervicalتعمل ك antagonist ضد ال sperm
+
+191
+00:13:42,650 --> 00:13:45,430
+يعني مجرد ما يتواجد ال sperm في منطقة ال cervical
+
+192
+00:13:45,430 --> 00:13:49,210
+هذه المواد بتعمل destructure ل ال sperm فبالتالي
+
+193
+00:13:49,210 --> 00:13:53,350
+ال sperm يفقد قدرته على الانتقال ثم يفقد قدرته على
+
+194
+00:13:53,350 --> 00:13:57,550
+الإخصاد ال ant sperm antibody من أهم هذه المواد
+
+195
+00:13:57,550 --> 00:14:01,750
+اللتي تعمل ك antagonist against sperm في بعض
+
+196
+00:14:01,750 --> 00:14:05,730
+الأحيان بيكون اندي two couples normal 100% ال male
+
+197
+00:14:05,730 --> 00:14:09,650
+و ال female لاندو crime level normalال Anatomy تبع
+
+198
+00:14:09,650 --> 00:14:12,490
+ال pelvic عند ال male و ال female normal ال
+
+199
+00:14:12,490 --> 00:14:15,630
+Anatomy ال productive system عند ال male و ال
+
+200
+00:14:15,630 --> 00:14:18,890
+female normal بنسبة 100% ولكن غير قادرين على
+
+201
+00:14:18,890 --> 00:14:24,090
+الإنجاب السبب أن هذه الزوجة أو هذه ال female عندها
+
+202
+00:14:24,090 --> 00:14:29,670
+ant sperm موجودة في منطقة ال cervic تشتغل ضد ال
+
+203
+00:14:29,670 --> 00:14:33,730
+sperm الخاص بهذا الرجل أو خاص بهذا الزوجة فبالتالي
+
+204
+00:14:33,940 --> 00:14:39,820
+لا يحدث تلقيح للبويضة حتى لو كانت البويضة نادجة
+
+205
+00:14:39,820 --> 00:14:43,360
+لأن مافيه spear بيصل للبويضة النادجة وبيعملها
+
+206
+00:14:43,360 --> 00:14:48,140
+عملية تلقيح فبالتالي ال ant spear من أهم الأسباب
+
+207
+00:14:48,140 --> 00:14:54,200
+التي تؤدي إلى منع تلقيح البويضة والتي تؤدي إلى قتل
+
+208
+00:14:54,200 --> 00:14:59,200
+الحيوان بمجرد تواجده في منطقة ال cervical فمجرد
+
+209
+00:14:59,200 --> 00:15:03,060
+أنه اشتغلت هذا ال ant spear ضد ال spear فبيعملها
+
+210
+00:15:03,320 --> 00:15:07,000
+انتاجونيست بتفقد ال capacity تبع ال sperm على ال
+
+211
+00:15:07,000 --> 00:15:11,260
+fertilization سؤال هل يمكن للذكر تكوين ant sperm
+
+212
+00:15:11,260 --> 00:15:14,980
+ضد نفسه أو ضد الحيوانات المنوية الخاصة فيه؟ صحيح
+
+213
+00:15:14,980 --> 00:15:20,560
+يمكن في أدت حالات رغم علميا أن ال testes الخاصة
+
+214
+00:15:20,560 --> 00:15:24,620
+بالميل موجودة في منطقة معزولة عن ال blood stream
+
+215
+00:15:24,620 --> 00:15:29,020
+بشكل كامل فبالتالي ما في الها ما بتعرضلها جهاز
+
+216
+00:15:29,020 --> 00:15:33,420
+المناعةولكن في لحظة من اللحظات بخطأ طبي بسيط على
+
+217
+00:15:33,420 --> 00:15:36,840
+سبيل المثال لو صار عندك trauma أو injury في منطقة
+
+218
+00:15:36,840 --> 00:15:39,800
+ال testis بيصير في عندك direct contact ما بين
+
+219
+00:15:39,800 --> 00:15:44,800
+immune system و ال testis فبادي إلى تكوين antibody
+
+220
+00:15:44,800 --> 00:15:48,600
+ضد ال sperm الخاص بهذا الإنسان فيصبح الإنسان غير
+
+221
+00:15:48,600 --> 00:15:52,260
+قادر على الإنجاب بفئة جهازه المناعي بفئة جهازه
+
+222
+00:15:52,260 --> 00:15:58,140
+المناعي فبتكون السيدة ما إلها سبب في تأخر الإنجاب
+
+223
+00:15:58,140 --> 00:16:01,740
+في هذه اللحظةفي أمور تانية بنسميها cervical factor
+
+224
+00:16:01,740 --> 00:16:06,140
+could be physical problem or mucus related problem
+
+225
+00:16:06,140 --> 00:16:10,340
+بعض الأحيان ال cervical factor قسموها إلى عوامل
+
+226
+00:16:10,340 --> 00:16:14,960
+فيزيائية علاقة مثلا بال thickness الخاصة بالميوكاس
+
+227
+00:16:14,960 --> 00:16:20,220
+أو عوامل ليس لها علاقة بال physical أبدا فعلى سبيل
+
+228
+00:16:20,220 --> 00:16:25,280
+المثال لو كان عندي cervical mucus very thick
+
+229
+00:16:25,280 --> 00:16:28,320
+الميوكاس الموجود في منطقة ال cervical عند السيدة
+
+230
+00:16:28,870 --> 00:16:33,770
+very very very thick هذا بيعمل كشبكة شبكة مغلقة
+
+231
+00:16:33,770 --> 00:16:39,250
+محكمة الإغلاق تمنع انتقال أي sperm داخل ال
+
+232
+00:16:39,250 --> 00:16:42,950
+cervical فبالتالي ما بيقطع ال cervical وما بيقطع
+
+233
+00:16:42,950 --> 00:16:47,270
+الرحم وما بيصل لل Fallopian tube فبالتالي ال
+
+234
+00:16:47,270 --> 00:16:51,130
+fertilization محصلة سفر فماعندي pregnancy صرفي
+
+235
+00:16:51,130 --> 00:16:55,670
+عندي infertility و لو كانت موقفة شغل تاني أقول ليه
+
+236
+00:16:56,310 --> 00:17:00,990
+الـ physical problem الخاصة بالـ cervic لها علاقة
+
+237
+00:17:00,990 --> 00:17:04,750
+بشكل كبير جدا جدا بالـ miscarriage والـ
+
+238
+00:17:04,750 --> 00:17:09,030
+miscarriage بشكل أساسي هو عبارة عن الإجهاض الـ
+
+239
+00:17:09,030 --> 00:17:12,870
+miscarriage زي ال abortion الإجهاض الـ mucus
+
+240
+00:17:12,870 --> 00:17:16,510
+related problem ممكن يؤدي لميوكس إلى عدة مشاكل
+
+241
+00:17:16,510 --> 00:17:20,750
+بفعل كمية الميوكس الموجودة في ال cervical غير
+
+242
+00:17:20,750 --> 00:17:25,380
+كافية فبالتاليالـ sperm غير قادر على البقاء طب إيش
+
+243
+00:17:25,380 --> 00:17:28,360
+دخل ال mucus في بقاء ال sperm؟ طب إحنا حكينا إن ال
+
+244
+00:17:28,360 --> 00:17:33,080
+mucus بيقتل ال sperm خد بالك يقتل ال sperm في حالة
+
+245
+00:17:33,080 --> 00:17:37,240
+زيادة ال thickness تبع ال mucus فبالتالي وجود ال
+
+246
+00:17:37,240 --> 00:17:41,780
+mucus في منطقة ال cervical بعمل عملية حماية لل
+
+247
+00:17:41,780 --> 00:17:45,380
+sperm من ال pH الخاص بال cervical ال pH اللي
+
+248
+00:17:45,380 --> 00:17:49,100
+موجودة عند السيدة لإن ال pH تبع ال male يختلف عن
+
+249
+00:17:49,100 --> 00:17:53,030
+ال pH تبع ال female فلو كان في عنديفيش عنده
+
+250
+00:17:53,030 --> 00:17:56,150
+ميوكاس، هيصير عنده shock للـ sperm ويصيرله
+
+251
+00:17:56,150 --> 00:18:01,650
+destructure فكمية الـ mucus المعقولة والكافية تعمل
+
+252
+00:18:01,650 --> 00:18:07,250
+حماية للـ sperm بعد الintercourses من أجل المحافظة
+
+253
+00:18:07,250 --> 00:18:10,390
+على الـ sperm بال full activity الخاصة فيه للوصول
+
+254
+00:18:10,390 --> 00:18:14,830
+إلى ال fallopian tube ففي حالة وجود كمية غير كافية
+
+255
+00:18:14,830 --> 00:18:19,770
+من الميوكاس، معناه ال survivor rate للـ sperm هقل
+
+256
+00:18:19,770 --> 00:18:27,060
+بشكل كبيرis too thick for sperm to survive لو كان
+
+257
+00:18:27,060 --> 00:18:32,500
+لدي الميوكاس ثقبته عالية جدا أو الدنسته عالية جدا
+
+258
+00:18:32,500 --> 00:18:37,160
+معناه أن كمية ال sperm اللي هتصل إلى الفلوبيا
+
+259
+00:18:37,160 --> 00:18:40,620
+هتكون قليلة جدا لأن الميوكاس في هذا اللحظة عمل زي
+
+260
+00:18:40,620 --> 00:18:45,400
+شبكة أسطاد كل sperm وعملهم ال structureالحاجة
+
+261
+00:18:45,400 --> 00:18:48,980
+التالتة بيسموها The Mucus Contains Spam Antibody
+
+262
+00:18:48,980 --> 00:18:53,160
+اتكلمنا عليها في مصابق ان الميوكاس نفسه في منطقة
+
+263
+00:18:53,160 --> 00:18:56,780
+الـ cervical الخاص بالفيميل يحتوي على Antibody
+
+264
+00:18:56,780 --> 00:19:00,580
+طبعا Antibody في هذه اللحظة السيدة اللتي تصنعه
+
+265
+00:19:00,580 --> 00:19:06,600
+وليس الراجل السيدة وليس الراجل السبب الرابع حاجة
+
+266
+00:19:06,600 --> 00:19:10,740
+بيسمونها الـ Belvic Adhesion ببساطة في بعض الأحيان
+
+267
+00:19:10,740 --> 00:19:14,900
+السيدات بتتعرض ل trauma في منطقة ال belvicأو تتعرض
+
+268
+00:19:14,900 --> 00:19:18,300
+لـ inflammation في منطقة الـ pelvic أو بتتعرض ل
+
+269
+00:19:18,300 --> 00:19:21,920
+surgical operation في منطقة الـ pelvic عملية الـ
+
+270
+00:19:21,920 --> 00:19:25,620
+healing للتيشو في منطقة الـ pelvic تؤدي في بعض
+
+271
+00:19:25,620 --> 00:19:29,480
+الأحيان إلى تكوين pelvic adhesion الـ pelvic
+
+272
+00:19:29,480 --> 00:19:32,460
+adhesion ببساطة زي ما احنا شايفنا في الصورة هي
+
+273
+00:19:32,460 --> 00:19:39,340
+عبارة عن فلمة اتطورت، نمت بشكل كبير جداعملت رابط
+
+274
+00:19:39,340 --> 00:19:42,960
+لبعض الأعضاء الموجودة في منطقة ال abdominal ومنطقة
+
+275
+00:19:42,960 --> 00:19:47,840
+ال pelvic عند السيدة فأدت إلى وجود anatomical ..
+
+276
+00:19:47,840 --> 00:19:50,560
+anatomical structure لـ reproductive system غير
+
+277
+00:19:50,560 --> 00:19:56,000
+طبيعي فأدى إلى عدم القدرة على الإنجاب عدم القدرة
+
+278
+00:19:56,000 --> 00:20:00,000
+على الإنجاب السبب الأساسي أن هذه السيدة اتعرضت ل
+
+279
+00:20:00,000 --> 00:20:04,200
+trauma inflammation surgical operation في منطقة ال
+
+280
+00:20:04,200 --> 00:20:08,350
+pelvic بعد فترة صار healing لل tissueالـ healing
+
+281
+00:20:08,350 --> 00:20:12,710
+كون filament الـ filament أملت ربط لبعض الأعضاء
+
+282
+00:20:12,710 --> 00:20:16,090
+الموجودة في منطقة ال بالبج مع بعض البعض فأدى إلى
+
+283
+00:20:16,090 --> 00:20:20,470
+تكوين anatomical structure abnormal shape او
+
+284
+00:20:20,470 --> 00:20:25,530
+abnormal anatomical structure أدى إلى تأخر الإنجاب
+
+285
+00:20:25,530 --> 00:20:30,730
+أو حدوث infertility سبب
+
+286
+00:20:30,730 --> 00:20:34,990
+الخامس الذي يعتبر من أسباب ال female infertility
+
+287
+00:20:34,990 --> 00:20:39,450
+هو عبارة عنOvulation Disorder يعني السيدة تمام
+
+288
+00:20:39,450 --> 00:20:42,830
+مافيش عندها Antisperm Antibody مافيش عندها Pelvic
+
+289
+00:20:42,830 --> 00:20:46,890
+Adhesion ال Anatomical Reproductive System Normal
+
+290
+00:20:46,890 --> 00:20:51,950
+ولكن في عندها مشكلة في عملية ال Ovulation نفسها
+
+291
+00:20:51,950 --> 00:20:56,190
+يعني في عملية التبويض نعرف بشكل أساسي و بشكل مبدئي
+
+292
+00:20:56,190 --> 00:21:00,710
+أن المتعرف عليه ان ال menstrual cycle لأي سيدة 28
+
+293
+00:21:00,710 --> 00:21:04,570
+يوم من إلى من لحظة ال bleeding إلى ال bleeding
+
+294
+00:21:05,390 --> 00:21:07,930
+التاني الموجود في الـ cycle التاني يعني 28 يوم
+
+295
+00:21:07,930 --> 00:21:11,510
+ولكن هذا ميثابت في بعضهم تصل لـ 30 وفي بعضهم تصل
+
+296
+00:21:11,510 --> 00:21:15,750
+لـ 36 يوم زي ما احنا بنعرف ان ال pleading time
+
+297
+00:21:15,750 --> 00:21:19,610
+تمان تيام في بعضهم أربع في بعضهم عشر في بعض
+
+298
+00:21:19,610 --> 00:21:24,030
+السيدات بيكون عندهم ovulation disorder يعني بمعنى
+
+299
+00:21:24,030 --> 00:21:28,110
+أخر ان في عوامل بتأثر على عملية ال egg releasing
+
+300
+00:21:28,110 --> 00:21:31,750
+ايش عن ال ovulation؟ ovulation هي عبارة عن التبويض
+
+301
+00:21:31,750 --> 00:21:35,500
+أو الإبادةإيش معنى التفويض أو الإبادة؟ هي عبارة عن
+
+302
+00:21:35,500 --> 00:21:39,800
+خروج البويضة الناضجة من الـ ovary إلى قناة
+
+303
+00:21:39,800 --> 00:21:42,500
+Fallopian هذه بسميها الـ ovulation طبعا دايما
+
+304
+00:21:42,500 --> 00:21:45,520
+بتصير في اليوم التلتاش أو اليوم الأربعة عشر من
+
+305
+00:21:45,520 --> 00:21:49,600
+الدورة الشهرية اللي بيسميها menstrual cycle بعض
+
+306
+00:21:49,600 --> 00:21:54,100
+السيدات عندهم مشكلة في وقت التفويض أو عندهم مشكلة
+
+307
+00:21:54,100 --> 00:21:57,060
+في قليل التفويض أو عندهم مشكلة في كيفية التفويض
+
+308
+00:21:57,060 --> 00:22:00,260
+عندهم عملية إخراج البويضةأو عملية الـ ovulation
+
+309
+00:22:00,260 --> 00:22:04,260
+بشكل الطبيعي لأ مابتحدث، أسبابها شوف في عندى
+
+310
+00:22:04,260 --> 00:22:07,320
+هرمون، فمش داخل الهرمون في الموضوع هذا؟ ببساطة
+
+311
+00:22:07,320 --> 00:22:10,440
+جدا، عارفين أن ال reproductive system و ال
+
+312
+00:22:10,440 --> 00:22:14,820
+ovulation ما بيصير إلا تحت تأثير الهرمونات، وأهمها
+
+313
+00:22:14,820 --> 00:22:19,740
+ال FSH و ال LH اللي فيما بعد بيحفظ الإنتاج
+
+314
+00:22:19,740 --> 00:22:23,500
+للبروجسترون و الاستروجين، وهذا هناخده بالتفصيل
+
+315
+00:22:23,500 --> 00:22:28,280
+الممل في chapter رقم 2 ان شاء اللهإذا الأول سبب من
+
+316
+00:22:28,280 --> 00:22:31,700
+أسباب الـ ovulation disorder أنه في عندي hormonal
+
+317
+00:22:31,700 --> 00:22:35,860
+disorder ومن أشهرها ال polycystic ovarian syndrome
+
+318
+00:22:35,860 --> 00:22:39,180
+شو مقصود بال polycystic ovarian syndrome؟ حاجة
+
+319
+00:22:39,180 --> 00:22:45,400
+بيسموها PCOS Polycystic
+
+320
+00:22:45,400 --> 00:22:50,020
+Ovarian Syndrome يعني في عندي تكييسات حول المبيض
+
+321
+00:22:50,020 --> 00:22:56,180
+تمنع عملية الإبادة تحجب عملية الإبادة تمنع خروج
+
+322
+00:22:57,400 --> 00:23:00,800
+البوايضة في ناس بتقولك لأ انه انا عندى الفوليكل
+
+323
+00:23:00,800 --> 00:23:05,420
+اللى موجود فيها البوايضة بتنتفخ و بتكبر لدرجة انه
+
+324
+00:23:05,420 --> 00:23:10,640
+انا لو شوفتها ال ultrasound باعتبرها فوليكل طبيعية
+
+325
+00:23:10,640 --> 00:23:16,140
+تحتوي على بوايضة طبيعية ناضجة ولكن لو دققت النظر
+
+326
+00:23:16,140 --> 00:23:20,020
+فيها بلاج الفوليكل فاضية مافيها بوايضة ناضجة عشان
+
+327
+00:23:20,020 --> 00:23:24,620
+كده بيسموها polycystic ovary syndrome polycystic
+
+328
+00:23:24,620 --> 00:23:29,720
+ovary syndrome يعني الفوليكلوصلت للديامتر الخاص
+
+329
+00:23:29,720 --> 00:23:33,740
+بالفوليكيل الناضجة ولكن في داخلها Zero بويضات
+
+330
+00:23:33,740 --> 00:23:38,440
+ناضجة سبب التاني حاجة بنتسميها Hyperproto .. حاجة
+
+331
+00:23:38,440 --> 00:23:44,200
+.. اللي لها علاقة بال .. ال .. Lactemia يعني ..
+
+332
+00:23:44,200 --> 00:23:47,960
+هرمون الحليب .. اللي لها علاقة بهرمون الحليب زيادة
+
+333
+00:23:47,960 --> 00:23:53,080
+في مستوى هرمون الحليب Prolactin hormone حاجة
+
+334
+00:23:53,080 --> 00:23:56,730
+بنتسميها Hyperprolactinemiaيعني مستوى هرمون الحليب
+
+335
+00:23:56,730 --> 00:24:01,330
+بيكون عالي جدا فبتتأخر عملية التبويض اللي احنا
+
+336
+00:24:01,330 --> 00:24:05,070
+بنسميها بالمصطلح العام تأخر الدورة عشان كده معظم
+
+337
+00:24:05,070 --> 00:24:07,990
+السيدات اللي بينجبوا و بكونوا في مرحلة الرضاعة ال
+
+338
+00:24:07,990 --> 00:24:11,150
+lactation بلاجئ الدورة ما بتيجي بشكل منتظم أو
+
+339
+00:24:11,150 --> 00:24:15,330
+بتتأخر شهرين تلاتة و ممكن تتأخر سنة كاملة عند بعض
+
+340
+00:24:15,330 --> 00:24:21,210
+السيدات سبب التالت لل ovulation disorder هي too
+
+341
+00:24:21,210 --> 00:24:24,890
+much thyroid hormone اللي بنسميهاhyperthyroidism
+
+342
+00:24:24,890 --> 00:24:28,630
+أو hypothyroidism سيدة عندها thyroid hormone
+
+343
+00:24:28,630 --> 00:24:32,270
+activity عالي جدا بتسميها hyperthyroidism أو very
+
+344
+00:24:32,270 --> 00:24:36,430
+low بتسميها hypothyroidism وهذا بيأثر بشكل كبير
+
+345
+00:24:36,430 --> 00:24:41,270
+جدا على ال ovulation و ال menstrual cycle عشان كده
+
+346
+00:24:41,270 --> 00:24:45,490
+أي سيدة .. خدوا بالكوا .. أي سيدة بتروح تعمل إجزي
+
+347
+00:24:45,490 --> 00:24:49,990
+تلقيح صناعي أو حق المجهري بيقصولها هرمونات ال FSH
+
+348
+00:24:49,990 --> 00:24:57,180
+و ال LH و ال E2والـ TSH هو Thyroid Stimulating
+
+349
+00:24:57,180 --> 00:25:00,280
+Hormone Thyroid Stimulating Hormone وكمان هرمون
+
+350
+00:25:00,280 --> 00:25:05,340
+جديد بيسموه AMH Anti-Mullerian Hormone وحنتكلم عنه
+
+351
+00:25:05,340 --> 00:25:09,360
+باستفادة شو هو الـ Anti-Mullerian Hormone علشان
+
+352
+00:25:09,360 --> 00:25:14,140
+كده مهم جدا الـ prolactin يكون طبيعي مهم جدا ال
+
+353
+00:25:14,140 --> 00:25:18,960
+FSH يكون طبيعي مهم جدا ال LH يكون طبيعي مهم جدا ال
+
+354
+00:25:18,960 --> 00:25:24,960
+E2مهم جداً الـ TSH يكون طبيعي قبل الزوجة أو السيدة
+
+355
+00:25:24,960 --> 00:25:31,140
+ما تروح تعمل إجزي وإلا هتدخل في برنامج علاجي يرجع
+
+356
+00:25:31,140 --> 00:25:35,520
+هذه الهرمونات لوضعها كالطبيعي ال other causes اللي
+
+357
+00:25:35,520 --> 00:25:39,960
+بتأدي إلى ال ovulation disorder بعض الأحيان أن هذه
+
+358
+00:25:39,960 --> 00:25:45,080
+السيدة بتعمل exercise بشكل hard exercise hard
+
+359
+00:25:45,080 --> 00:25:50,490
+exercise بيأدي إلى حدوث تلفعندها في بعض المناطق
+
+360
+00:25:50,490 --> 00:25:54,050
+الخاصة بال reproductive system eating disorder أو
+
+361
+00:25:54,050 --> 00:26:00,190
+tumor بعض الأحيان بصير عندها tumor في منطقة ال
+
+362
+00:26:00,190 --> 00:26:04,650
+بالبك tumor في ال ovary tumor في الفلوجياليتيوب
+
+363
+00:26:04,650 --> 00:26:10,530
+تمنع عملية ال ovulation بالشكل الطبيعي سبب سادس من
+
+364
+00:26:10,530 --> 00:26:15,050
+أسباب ال female infertility وهو primary ovarian
+
+365
+00:26:15,050 --> 00:26:15,770
+insufficiency
+
+366
+00:26:18,060 --> 00:26:20,240
+What's the meaning of the primary or variant
+
+367
+00:26:20,240 --> 00:26:24,200
+sufficient هو عبارة عن ال early monopioes ال
+
+368
+00:26:24,200 --> 00:26:27,740
+monopioes أنا ما بدي أسميها فترة اليأس أو زمن
+
+369
+00:26:27,740 --> 00:26:32,500
+اليأس أو وقت اليأس أنا بسميها لبساطة جدا انقطاع
+
+370
+00:26:32,500 --> 00:26:37,700
+الدورة أو انقطاع الطمف بعضهم من أجل تغيير الوصولات
+
+371
+00:26:37,700 --> 00:26:43,100
+بسميها سن الأمد لأ هو عبارة عن وقت انقطاع الدورة
+
+372
+00:26:43,100 --> 00:26:47,980
+أو وقت انقطاع الطمف بسموها monopioesفي هذا السبب
+
+373
+00:26:47,980 --> 00:26:52,220
+اللي بنسميه Primary Ovarian Insufficiency إله اسم
+
+374
+00:26:52,220 --> 00:26:56,980
+آخر وهو الـ Early Monobiosis السيدة بشكلها الطبيعي
+
+375
+00:26:56,980 --> 00:27:00,040
+و بعمرها الطبيعي و ال physiological الطبيعية
+
+376
+00:27:00,040 --> 00:27:03,100
+الخاصة فيها تصل لـ Monobiosis أربعين و أحد و
+
+377
+00:27:03,100 --> 00:27:05,860
+أربعين و أتنين و أربعين سنة يعني لما تصل لعمر من
+
+378
+00:27:05,860 --> 00:27:08,020
+أربعين لتانين و أربعين سنة المفروض كانت وصلت لـ
+
+379
+00:27:08,020 --> 00:27:10,940
+Monobiosis و هنعرف أيش الأسباب التي تؤدي إلى الـ
+
+380
+00:27:10,940 --> 00:27:16,830
+Monobiosis ولكن لكل قاعدةشواذ في بعض السيدات ما
+
+381
+00:27:16,830 --> 00:27:20,290
+بتصل لـ Monobios على ال 40 بتصل على 35 هذا
+
+382
+00:27:20,290 --> 00:27:25,250
+بنتسميها Early Monobios Early Monobios و طبعا
+
+383
+00:27:25,250 --> 00:27:29,390
+بعضهم أو بعض المقالات بتقولك أنه .. و بعض المراجع
+
+384
+00:27:29,390 --> 00:27:34,530
+بتقولك أن أسبابها unknown حتى الآن ولكن في factors
+
+385
+00:27:34,530 --> 00:27:39,850
+تساعد و ترتبط بال Early Monobios منها عندك problem
+
+386
+00:27:39,850 --> 00:27:42,790
+في ال immune systemهيصير ال immune system يشتغل
+
+387
+00:27:42,790 --> 00:27:48,070
+على ال بويضات المخزنة بيدمرها وبتصل ل 35-36 ما
+
+388
+00:27:48,070 --> 00:27:52,010
+بيكون عندها مخزون وبتتوقف الدورة عندها او بعض اللي
+
+389
+00:27:52,010 --> 00:27:54,410
+أحيان بيقولك في عندي genetical condition زي
+
+390
+00:27:54,410 --> 00:27:58,790
+الternal syndrome زي ال fragile egg syndrome أو
+
+391
+00:27:58,790 --> 00:28:01,530
+بعض السيدات اللي بتتعرضوا لل radiotherapy و ال
+
+392
+00:28:01,530 --> 00:28:06,150
+chemotherapy إذا هذه عبارة عن تلت عوامل أساسية
+
+393
+00:28:06,150 --> 00:28:11,860
+تساعد وتدفعالسيدة للوصول إلى الـ Airline Monobios
+
+394
+00:28:11,860 --> 00:28:15,840
+قبل الوقت الطبيعي يعني قبل الأربعين في خلصه تلقين
+
+395
+00:28:15,840 --> 00:28:21,420
+ستة أولوية طيب خلصنا من أسباب الـ Monobios عند
+
+396
+00:28:21,420 --> 00:28:25,500
+الفيميل عفوا خلصنا عند أعوام الـ Monobios أو
+
+397
+00:28:25,500 --> 00:28:29,820
+Airline Monobios عند الفيميل وبالتالي أنهينا
+
+398
+00:28:29,820 --> 00:28:34,460
+الأسباب التي تؤدي إلى الـ Female Infertility نيجي
+
+399
+00:28:34,460 --> 00:28:37,000
+لـ Male Infertility ولكن قبل ما نيجي لـ Male
+
+400
+00:28:37,000 --> 00:28:44,480
+Infertilityمش صح إنه أنا أرجع و أعود بأسباب ال
+
+401
+00:28:44,480 --> 00:28:48,240
+infertility إلى شخص دون الآخر أو إلى جنس دون الآخر
+
+402
+00:28:48,240 --> 00:28:52,420
+ولا بقول إن ال infertility لها علاقة بال female أو
+
+403
+00:28:52,420 --> 00:28:56,200
+لها علاقة بال male لأ في أسباب خاصة بال male في
+
+404
+00:28:56,200 --> 00:28:59,600
+أسباب خاصة بال female فبالتالي قبل ما أطلق أي حاجة
+
+405
+00:28:59,600 --> 00:29:04,640
+و أقول إن ال infertility خاصة بال female فبالتالي
+
+406
+00:29:04,640 --> 00:29:08,690
+لازم أنا أستشير طبيبأستشير أخصائي البريولوجيست
+
+407
+00:29:08,690 --> 00:29:13,050
+أعمل الفحوصات المطلوبة عشان أحدد السبب علشان بعد
+
+408
+00:29:13,050 --> 00:29:17,230
+تحديد السبب بدأ الإلاج فبالتالي ما بلقي التهم
+
+409
+00:29:17,230 --> 00:29:22,750
+جوزافة أسباب ال male infertility بداية لما أقول
+
+410
+00:29:22,750 --> 00:29:27,110
+أنا عندي infertility عند ال male معناه إن هذا ال
+
+411
+00:29:27,110 --> 00:29:33,920
+male قد ينتج seminal fluid ولكن مافي spermأو قد
+
+412
+00:29:33,920 --> 00:29:38,000
+ينتج seminal fluid وفي sperm ولكن الـ sperm non
+
+413
+00:29:38,000 --> 00:29:41,840
+-functional يعني بمعنى أخر ممكن يكون أنا عندي
+
+414
+00:29:41,840 --> 00:29:46,040
+مشكلة في ال seminal fluid composition أو ممكن يكون
+
+415
+00:29:46,040 --> 00:29:50,700
+عندي مشكلة في المصنع و هو ال testis بس لأ ممكن
+
+416
+00:29:50,700 --> 00:29:54,780
+يكون عندي مشكلة أيضا في القنابيب الناقلة من المصنع
+
+417
+00:29:54,780 --> 00:29:59,080
+إلى ال .. إلى ال .. إلى .. خلّيني أسميه ال ..
+
+418
+00:30:02,470 --> 00:30:05,710
+النبوبة القاضي فخلّيني أسميها بهذا الشكل فبالتالي
+
+419
+00:30:05,710 --> 00:30:10,510
+في عندي مرحلة التصنيع مرحلة النقل والمنتج المنتج
+
+420
+00:30:10,510 --> 00:30:13,330
+هو عبارة عن الـ seminal fluid ممكن يكون عندي مشكلة
+
+421
+00:30:13,330 --> 00:30:16,770
+في مرحلة التصنيع في المصنع في المصنع هو ال testis
+
+422
+00:30:16,770 --> 00:30:20,890
+ممكن يكون عندي مشكلة في ال vas deferens وهو
+
+423
+00:30:20,890 --> 00:30:24,570
+الأنابيب الناقلة وممكن يكون عندي مشكلة في العينة
+
+424
+00:30:24,570 --> 00:30:29,570
+يعني كل ما سبق طبيعي ولكن المشكلة في العينة بمعنى
+
+425
+00:30:29,570 --> 00:30:35,090
+آخرإن العينة ما فيها sperm أو العينة فيها sperm
+
+426
+00:30:35,090 --> 00:30:38,670
+ولكن عدده قليل أو العينة فيها sperm وعدده 100%
+
+427
+00:30:38,670 --> 00:30:42,170
+ولكن non-functional غير قادر على الإتجاب أو غير
+
+428
+00:30:42,170 --> 00:30:45,910
+قادر على التلقيح هي المقصود فيه فبالتالي ال
+
+429
+00:30:45,910 --> 00:30:51,810
+problem with sperm ال problem with sperm خلّيني
+
+430
+00:30:51,810 --> 00:30:56,750
+أقول إن الأسباب المرتبطة بالعقوم عند الرجال لها
+
+431
+00:30:56,750 --> 00:31:02,790
+عدة سببلو أنا بتاخد على مستوى ال testis فيه أسباب
+
+432
+00:31:02,790 --> 00:31:05,770
+على مستوى ال fast difference و العنابيب الناقلة
+
+433
+00:31:05,770 --> 00:31:09,970
+فيه أسباب و عوامل على مستوى العينة بحد ذاتها فيه
+
+434
+00:31:09,970 --> 00:31:15,130
+أسباب و عوامل أيضا ولكن بشكل عام أن عندي some man
+
+435
+00:31:15,130 --> 00:31:19,950
+produce no sperm فبسميه asospermia زي ما حكينا في
+
+436
+00:31:19,950 --> 00:31:25,350
+slide ما قبل الأخيرة المحاضرة السابقة أو somemale
+
+437
+00:31:25,350 --> 00:31:29,950
+produce seminal fluid with a few number of sperm
+
+438
+00:31:29,950 --> 00:31:34,050
+بنسميها oligospermia العينة ككل بنسميها seminal
+
+439
+00:31:34,050 --> 00:31:38,930
+fluid ال sperm ال بالداخل إذا كان طبيعي بنسميه
+
+440
+00:31:38,930 --> 00:31:43,250
+normal seminal fluid طبعا إذا كان طبيعي من حياته
+
+441
+00:31:43,250 --> 00:31:47,970
+العدد من حياته الحركة من حياته الحجم ومن حياته ال
+
+442
+00:31:47,970 --> 00:31:51,070
+progressive motility اللي هتكلم عنها بشكلها الأوضح
+
+443
+00:31:51,070 --> 00:31:55,780
+ولكن إذا كان عدد الحيوانات المنوية في العينةأقل من
+
+444
+00:31:55,780 --> 00:32:02,340
+20 مليون بسميها Oligospermia بسميها Oligospermia
+
+445
+00:32:02,340 --> 00:32:06,380
+طيب other problem include في عندي sexual
+
+446
+00:32:06,380 --> 00:32:11,020
+dysfunction عند مشاكل في الأعضاء التناثورية الخاصة
+
+447
+00:32:11,020 --> 00:32:14,440
+بالميل فبالتالي ما بتقوم بالوظيفة المطلوبة منه
+
+448
+00:32:14,440 --> 00:32:18,420
+ومنها في عندي hormonal and endocrine abnormality
+
+449
+00:32:18,420 --> 00:32:23,570
+مثلا عند مشكلة في ال FSH عند مشكلة في ال LHعندي
+
+450
+00:32:23,570 --> 00:32:27,330
+مشكلة في الـ Testosterone لأنه هو الهرمون الذكوري
+
+451
+00:32:27,330 --> 00:32:30,470
+الموجود عند الذكور و ال Progesterone هو الهرمون
+
+452
+00:32:30,470 --> 00:32:34,950
+الأنثوي الموجود عند الإناس فبالتالي لو كان عندي
+
+453
+00:32:34,950 --> 00:32:38,390
+مشكلة في ال FSH و ال LH ال Testosterone معناه
+
+454
+00:32:38,390 --> 00:32:42,370
+مشكلة عندي في عملية الإنتاج Infection صار عند هذا
+
+455
+00:32:42,370 --> 00:32:45,710
+ال male Infection في ال testis أو Infection في ال
+
+456
+00:32:45,710 --> 00:32:50,690
+accessory gland أو حاجة نسموها الغدد المساعدة
+
+457
+00:32:50,750 --> 00:32:54,210
+فبالتالي مش هينتج حيوانات منوية بالشكل المطلوب و
+
+458
+00:32:54,210 --> 00:32:57,530
+بالكم المطلوب و بالكفاءة المطلوب Congenital
+
+459
+00:32:57,530 --> 00:33:02,290
+problems like pear defect such as the absence of
+
+460
+00:33:02,290 --> 00:33:05,130
+tubule that carried the sperm و هي ال vase
+
+461
+00:33:05,130 --> 00:33:09,430
+difference بعض الذكور بيولدوا عندهم مشكلة في ال
+
+462
+00:33:09,430 --> 00:33:12,390
+vase difference و هو القنطوب الناقل أو الوعاء
+
+463
+00:33:12,390 --> 00:33:17,470
+الناقل مفقود فبالتالي المصنع شغال و يخلق ولكن مافي
+
+464
+00:33:17,470 --> 00:33:22,400
+شيء ينقل من الداخل للخارجطبعا هدولة يعتبروا
+
+465
+00:33:22,400 --> 00:33:27,180
+infertile .. infertile غير قادر عن جبب بشكل طبيعي
+
+466
+00:33:27,180 --> 00:33:32,500
+ولكن لو أنا روحت أعملتله حاجة بتسميها تيسا أو بيسا
+
+467
+00:33:32,500 --> 00:33:36,440
+يكون .. ممكن يكون قادر عن جبب طبعا شو التيسا و شو
+
+468
+00:33:36,440 --> 00:33:41,740
+البيسا هتكلم عنها في محاضرات لاحقة إن شاء الله
+
+469
+00:33:41,740 --> 00:33:47,400
+ببساطة تعريفة أنا باخد عينة أو خزعة من ال testis
+
+470
+00:33:47,400 --> 00:33:52,570
+نفسهGenetic Chromosomal Abnormality من الأسباب
+
+471
+00:33:52,570 --> 00:33:56,910
+التي قد تؤدي إلى المال Infertility بعض الأسباب
+
+472
+00:33:56,910 --> 00:34:00,910
+والمشاكل التي لها علاقة بالكرومزوم أو بعض المشاكل
+
+473
+00:34:00,910 --> 00:34:05,250
+الجينية Anti-Sperm Antibody حكينا أن المال يمكن
+
+474
+00:34:05,250 --> 00:34:08,710
+يكون Anti-Sperm Antibody صحيح ضد نفسه إذا اتعرض
+
+475
+00:34:08,710 --> 00:34:12,410
+لترومة في منطقة الـ Reproductive System
+
+476
+00:34:12,410 --> 00:34:16,510
+الـVaricoseal الدوالي وهي عبارة عن انتفاخات في
+
+477
+00:34:16,510 --> 00:34:20,200
+الأواعي الدموية الموصلة لهالدم والغذاء الى ال
+
+478
+00:34:20,200 --> 00:34:24,280
+testis فبتصير عندي Varicosel تؤدي الى تأخر الإنجاب
+
+479
+00:34:24,280 --> 00:34:27,460
+يعني تؤدي الى infertility لها علاج صحيح لها علاج
+
+480
+00:34:27,460 --> 00:34:30,760
+ال lifestyle ممكن تأثر على ال number و ال quality
+
+481
+00:34:30,760 --> 00:34:35,300
+تبع ال sperm ال lifestyle يعني تتحدث عنها بلا حرج
+
+482
+00:34:35,300 --> 00:34:42,020
+زى التدخين زى الدخان و الشيشة و العمل في مصنع
+
+483
+00:34:42,020 --> 00:34:45,360
+البطاريات العمل في مصانع ال sponge التعرض لدرجات
+
+484
+00:34:45,360 --> 00:34:49,300
+حرارة عالية لفترة وقت زمنية طويلةالتعرض للفسفور
+
+485
+00:34:49,300 --> 00:34:55,560
+الأبيض وخلافه الالكحول and drug ممكن تسبب
+
+486
+00:34:55,560 --> 00:34:59,000
+abnormality وممكن في ال semen parameter أو ممكن
+
+487
+00:34:59,000 --> 00:35:02,700
+تؤدي إلى reduction في ال seminal quality أو في ال
+
+488
+00:35:02,700 --> 00:35:06,440
+sperm quality بشكل مؤقت لأن ال cigarette smoking
+
+489
+00:35:06,440 --> 00:35:09,640
+تأثيره عند ال male يختلف عن تأثيره عند ال female
+
+490
+00:35:09,640 --> 00:35:13,560
+ولكن اللي بدأنا أعرفه أن الالكحول و ال cigarette
+
+491
+00:35:13,560 --> 00:35:16,920
+smoking في الغالب تأثيره بكون temporary عند ال
+
+492
+00:35:16,920 --> 00:35:23,790
+maleلأن الـ seminal fluid أو الـ sperm ما بيخزن
+
+493
+00:35:23,790 --> 00:35:27,630
+لفترات زمنية طويلة جدا لأ هو في حالة تخليق بشكل
+
+494
+00:35:27,630 --> 00:35:31,070
+مستمر فلو أتوقف الإنسان عن شرب الكحول أو عن تناول
+
+495
+00:35:31,070 --> 00:35:35,010
+التدخين برجع الأمر لوضعه الطبيعي ولكن بعد فترة
+
+496
+00:35:35,010 --> 00:35:40,330
+زمنية معينة ال environment toxin المتعرض لها خاصة
+
+497
+00:35:40,330 --> 00:35:46,590
+ال pesticide والمواد الثقيلة والمواد الإشعاعيةبعض
+
+498
+00:35:46,590 --> 00:35:50,570
+الأحيان بيصنف بعض الحالات unexplained infertility
+
+499
+00:35:50,570 --> 00:35:54,310
+اديوباثيك يعني كله طبيعي مية في المية الإنتاج مية
+
+500
+00:35:54,310 --> 00:35:55,910
+في المية الهرمونات مية في المية ال reproductive
+
+501
+00:35:55,910 --> 00:35:58,630
+system مية في المية مافي عنده antiferrent body
+
+502
+00:35:58,630 --> 00:36:02,230
+مافي عنده ال percocial lifestyle مية في المية مافي
+
+503
+00:36:02,230 --> 00:36:05,490
+عنده مشكلة ولكن والجيلاتك برضه مافي عنده مشكلة
+
+504
+00:36:05,490 --> 00:36:09,570
+جينية أو مافي عنده مشكلة جينية ولكن يصنف infertile
+
+505
+00:36:09,570 --> 00:36:15,200
+تحت عنوان adiopathic infertility أوExcipline
+
+506
+00:36:15,200 --> 00:36:19,720
+Infertility يعني أسباب غير معروفة طبعا عندي
+
+507
+00:36:19,720 --> 00:36:24,280
+بالنسبة لل infertility cases .. courses عندي 30%
+
+508
+00:36:24,280 --> 00:36:28,660
+اللي لها علاقة بالمال عندي 30% اللي لها علاقة بال
+
+509
+00:36:28,660 --> 00:36:32,560
+female عندي 10% اللي لهم علاقة بال male و female
+
+510
+00:36:32,560 --> 00:36:38,480
+25% تعتبر idiopathic و 5% غير معروفين حتى مش
+
+511
+00:36:38,480 --> 00:36:42,740
+مصنفين ك idiopathic بدي أنا قبل ما أختم هذه
+
+512
+00:36:42,740 --> 00:36:46,850
+المحاضرةبدي أحكي ببساطة جدا أن كمية و نسبة ال
+
+513
+00:36:46,850 --> 00:36:51,330
+infertility في الواقع اللي بيعيش في قطاع غزة زادت
+
+514
+00:36:51,330 --> 00:36:57,210
+بعد حرب 2008 بشكل ملحوظ جدا بعد حرب 2012 and المية
+
+515
+00:36:57,210 --> 00:37:00,510
+طبعا بعد حرب 2012 صار and the recurrent abortion
+
+516
+00:37:00,510 --> 00:37:06,870
+بشكل ملحوظ جدا وصوصا عند سكان المناطق الحدودية
+
+517
+00:37:06,870 --> 00:37:09,950
+سواء المناطق الشرقية أو المناطق الشمالية قد يكون
+
+518
+00:37:09,950 --> 00:37:14,440
+له علاقةوقد يكون .. وقد لا يكون له علاقة بمخلفات
+
+519
+00:37:14,440 --> 00:37:18,280
+الحروب هذا بيحتاج إلى دراسة ولكن ما تم لمسه على
+
+520
+00:37:18,280 --> 00:37:21,600
+أرض الواقع أن ال male infertility زادت بعد حرب
+
+521
+00:37:21,600 --> 00:37:26,540
+2008 و ال miscarriage أو ال recurrent abortion أو
+
+522
+00:37:26,540 --> 00:37:31,560
+التشوهات الجنينية التي تظهر على الأجنة بعد عملية
+
+523
+00:37:31,560 --> 00:37:34,800
+ال miscarriage أو بعد عملية ال abortion كانت عالية
+
+524
+00:37:34,800 --> 00:37:40,580
+بعد حرب 2012 في المناطق القدودية الشرقية والشمالية
+
+525
+00:37:40,830 --> 00:37:44,530
+سوف نكتفي بهذا القدر في محاضرة اليوم، على أمل أن
+
+526
+00:37:44,530 --> 00:37:48,290
+نستكمل في المحاضرة التالية تحت عنوان Primary
+
+527
+00:37:48,290 --> 00:37:53,470
+Fertility and Secondary Infertility، دمتم في حفظ
+
+528
+00:37:53,470 --> 00:37:54,570
+الله ورياه حياتي
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/DYESKICx4QA.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/DYESKICx4QA.srt
new file mode 100644
index 0000000000000000000000000000000000000000..516b43c33f70fdd2c6c69067fb38ea9fc0f3fe1f
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/DYESKICx4QA.srt
@@ -0,0 +1,1691 @@
+1
+00:00:00,770 --> 00:00:04,450
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:04,450 --> 00:00:09,830
+المرسلين سيدنا محمد وعلى آله وصحبه أجمعين، طلابنا 
+
+3
+00:00:09,830 --> 00:00:14,270
+العزاء، أرجو من الله أن تكونوا بخير. استكمالًا لما
+
+4
+00:00:14,270 --> 00:00:17,930
+بدأنا فيه من محاضرة sperm assessment processing
+
+5
+00:00:17,930 --> 00:00:22,230
+and selection، تحدثنا عن عدة أمور لها علاقة بالـ
+
+6
+00:00:22,230 --> 00:00:25,170
+macroscopic examination والـmicroscopic examination.
+
+7
+00:00:25,870 --> 00:00:29,110
+وفي النهاية، تحدثنا عن الـVatility Test أو الـLife 
+
+8
+00:00:29,110 --> 00:00:33,450
+Sperm Examination من خلال فحص الأيوزين أو
+
+9
+00:00:33,450 --> 00:00:38,150
+النجروسين. استكمالًا لهذا الأمر، سوف نتكلم عن
+
+10
+00:00:38,150 --> 00:00:41,610
+الـHoss Test أو ما يُعرف باسم الـHypoosmotic
+
+11
+00:00:41,610 --> 00:00:45,770
+Swelling Test. الـHypoosmotic Swelling Test، اختصار 
+
+12
+00:00:45,770 --> 00:00:50,910
+Hoss Test، وهو عبارة عن فحص يُستخدم للتفريق ما بين
+
+13
+00:00:50,910 --> 00:00:56,570
+الحيوان المنوي الحي والحيوان المنوي الميت. وهو كفحص 
+
+14
+00:00:56,570 --> 00:01:00,850
+مهم جدًا خلال عملية الـ fertilization، لأنه أنا بهمني 
+
+15
+00:01:00,850 --> 00:01:05,590
+أن أحقن الخلية بحيوان منوي حي، حتى لو كان غير متحرك.
+
+16
+00:01:05,590 --> 00:01:10,890
+فالمهم أن يكون حي. The principle: only living cell 
+
+17
+00:01:10,890 --> 00:01:14,590
+with intact membrane will swell under hypoosmotic
+
+18
+00:01:14,590 --> 00:01:20,530
+condition 150 mO·L. يعني مبدأ عمل هذا الفحص أن 
+
+19
+00:01:20,530 --> 00:01:25,960
+الخلايا الحية تميل إلى الـ swelling في حالة تعرضها
+
+20
+00:01:25,960 --> 00:01:30,480
+إلى الـ hypo osmotic condition. يعني أنا أي خلية
+
+21
+00:01:30,480 --> 00:01:34,400
+أحطها في hypo osmotic condition هتنتفخ. وهذه نفس
+
+22
+00:01:34,400 --> 00:01:39,360
+الفكرة في الـ host test أو الـ hypo osmotic
+
+23
+00:01:39,360 --> 00:01:44,540
+swelling: the influx of a fluid into via pedicel is 
+
+24
+00:01:44,540 --> 00:01:49,020
+reflected by the coiling of the sperm. يعني الـ
+
+25
+00:01:49,020 --> 00:01:53,080
+sperm إذا كان هذا الـ sperm حيوضعته في hypo-osmotic
+
+26
+00:01:53,080 --> 00:01:57,640
+swelling or solution مباشرة، نهاية التل الخاصة به 
+
+27
+00:01:57,640 --> 00:02:02,200
+هتنتفخ، معناه إن والله هذا الـ sperm life، هذا الـ
+
+28
+00:02:02,200 --> 00:02:07,660
+sperm available or life. أحد أفضليات هذا الاختبار هو
+
+29
+00:02:07,660 --> 00:02:13,460
+أنه لا يقتل الـ sperm، الفحص الذي يسمح بالتوليد لهذا الـ sperm.
+
+30
+00:02:13,460 --> 00:02:18,500
+للتكنولوجيا التجاربية. يعني بمعنى آخر أن هذا الفحص 
+
+31
+00:02:18,500 --> 00:02:21,480
+لا يؤثر على الـ sperm، ما بيأثر على المادة الوراثية 
+
+32
+00:02:21,480 --> 00:02:24,240
+بتاعة الـ sperm، ما بيأثر على الـ function بتاعة الـ sperm،
+
+33
+00:02:24,240 --> 00:02:28,640
+ما بيأثر على الـ capacity بتاعة الـ sperm. فبالتالي أي Sperm 
+
+34
+00:02:28,640 --> 00:02:32,600
+أخضعته لهذه العملية واتضح فيما بعد أن الـ life 
+
+35
+00:02:32,600 --> 00:02:39,220
+ممكن أن أستخدمه في الـ IVF بشكل مباشر بدون أي تردد. In 
+
+36
+00:02:39,220 --> 00:02:42,100
+this method, sperm sample should be mixed with the 
+
+37
+00:02:42,100 --> 00:02:46,660
+hypoosmotic solution and incubated at 37 Celsius 
+
+38
+00:02:46,660 --> 00:02:50,700
+for 30 minutes. عشان أنا أتأكد هذا الـ sperm alive
+
+39
+00:02:50,700 --> 00:02:54,320
+ولا لا. طب إذا كانت العينة بتستخدمها للإخصاب يكفي 
+
+40
+00:02:54,320 --> 00:02:59,910
+خمس دقائق تحضيرها بالـ hypoosmotic solution. بعد 
+
+41
+00:02:59,910 --> 00:03:05,930
+عملية الحضانة على 37 درجة مئوية لمدة 30 دقيقة أو 
+
+42
+00:03:05,930 --> 00:03:11,150
+لمدة 5 دقائق، باجي بعمل check up للـ sperm، أو بعد الـ
+
+43
+00:03:11,150 --> 00:03:16,070
+sperm بعمل with preparation على الـ slide. should be 
+
+44
+00:03:16,070 --> 00:03:19,170
+made and assess the sample under phase contrast 
+
+45
+00:03:19,170 --> 00:03:23,630
+microscope على عدسة تكبير 400 أو 200، بعيد 200.
+
+46
+00:03:23,630 --> 00:03:28,330
+sperm، بشوف مين فيهم life ومين فيهم dead. بناء على 
+
+47
+00:03:28,330 --> 00:03:34,450
+الانتفاخ اللي يظهر أسفل الذيل في هذا الشكل، طبعًا دي 
+
+48
+00:03:34,450 --> 00:03:37,890
+اللي على اليسار رقم A هي عبارة عن الـ fertility 
+
+49
+00:03:37,890 --> 00:03:42,590
+test بفعل الـ نجروسين أو الـ Iosin. بضيف قطرة من الـ
+
+50
+00:03:42,590 --> 00:03:46,170
+Iosin، بضيف قطرة من الـ نجروسين، و بضيف قطرة من الـ semen
+
+51
+00:03:46,170 --> 00:03:50,450
+بعمله mix. أو واحد semen اتنين drop Iosin، اتنين drop
+
+52
+00:03:50,450 --> 00:03:54,170
+نجروسين، بعمل mix وبشوفها تحت الـ microscope اللي 
+
+53
+00:03:54,170 --> 00:04:00,980
+بالشب هو الـ life. أما الأخر صفقة الـ Iosin هو الـ 
+
+54
+00:04:00,980 --> 00:04:05,340
+dead أو الـ non-viable. اللي على اليسار هي عبارة عن
+
+55
+00:04:05,340 --> 00:04:09,700
+الـ hypo osmotic swelling test، الـ host test. بضيف 
+
+56
+00:04:09,700 --> 00:04:14,140
+sample من الـ seminal fluid، بضيف عليه الـ hypo
+
+57
+00:04:14,140 --> 00:04:18,180
+osmotic swelling fluid or solution وبعمل mixing
+
+58
+00:04:18,180 --> 00:04:24,900
+وincubation لمدة 30 أو 5 دقائق على 37 درجة مئوية. أي
+
+59
+00:04:24,900 --> 00:04:29,440
+sperm بظهر له swelling في أسفله، هذا معناه normal
+
+60
+00:04:29,440 --> 00:04:32,280
+sperm swelling زي ما أحنا شايفينه على جهة اليسار
+
+61
+00:04:32,280 --> 00:04:36,840
+في منطقة التل. بسميه normal sperm، viable sperm. أما
+
+62
+00:04:36,840 --> 00:04:39,800
+إذا كان مافيه swelling في نهاية التل فهو عبارة عن 
+
+63
+00:04:39,800 --> 00:04:45,420
+non viable sperm أو dead sperm. هذا الفرق ما بين
+
+64
+00:04:45,420 --> 00:04:50,220
+الفرقتين. في طريقة ثانية وهي طريقة العد معتمدة على 
+
+65
+00:04:50,220 --> 00:04:54,480
+الكمبيوتر. بنسميها Computerized
+
+66
+00:04:54,480 --> 00:05:00,560
+Assisted Sperm Analysis أو Computer Assisted Sperm
+
+67
+00:05:00,560 --> 00:05:07,840
+Analysis، تحت مصطلح كذا كذا، C للكمبيوتر، A Assisted
+
+68
+00:05:07,840 --> 00:05:12,940
+Sperm Analysis. يعني أنت كـ technician ما بتشتغل شيء إلا
+
+69
+00:05:12,940 --> 00:05:16,360
+بتعمل weight mount. يعني كـ technician بتضيف 50 micro من 
+
+70
+00:05:16,730 --> 00:05:19,590
+عينة الـ Seminal Fluid بعد الـ mix الجيد، وبتغطيها 
+
+71
+00:05:19,590 --> 00:05:22,930
+بـ cover slide وبتدخلها تحت الـ microscope، والـ
+
+72
+00:05:22,930 --> 00:05:26,550
+microscope بناء على software معين بيقرأ كل الـ
+
+73
+00:05:26,550 --> 00:05:29,870
+field، بيهدلك الـ sperm وبيجيبلك الـ motility، و
+
+74
+00:05:29,870 --> 00:05:34,130
+بيجيبلك الـ morphology، حتى بيجيبلك تصنيف الـ motile
+
+75
+00:05:34,130 --> 00:05:37,830
+هل هي الـ progressive ولا non progressive motile. ولكن 
+
+76
+00:05:37,830 --> 00:05:42,410
+خد بالك أنه لازم بنعمل check-up على نتائجه لأن في 
+
+77
+00:05:42,410 --> 00:05:47,270
+نسبة خطأ منها بفعل أن بعض الـ Debris ممكن يعدها كـ
+
+78
+00:05:47,270 --> 00:05:56,030
+sperm. خلينا نشوف الفيديو متعلق بعد الموضوع، نشوف
+
+79
+00:05:56,030 --> 00:05:59,030
+الفيديو. Motility and concentration sample 
+
+80
+00:05:59,030 --> 00:06:03,290
+preparation. First step is to prepare a sample for 
+
+81
+00:06:03,290 --> 00:06:05,410
+motility and concentration analysis.
+
+82
+00:06:12,750 --> 00:06:13,950
+يمكن استخدام بطاريات مستخدمة. يمكن استخدامها 
+
+83
+00:06:13,950 --> 00:06:16,590
+بطاريات مستخدمة. يمكن استخدامها. بطاريات مستخدمة
+
+84
+00:06:16,590 --> 00:06:20,710
+يمكن استخدامها. بطاريات مستخدمة. يمكن استخدامها
+
+85
+00:06:20,710 --> 00:06:21,250
+بطاريات مستخدمة. يمكن استخدامها. بطاريات مستخدمة
+
+86
+00:06:21,250 --> 00:06:23,670
+يمكن استخدامها. بطاريات مستخدمة. يمكن استخدامها
+
+87
+00:06:23,670 --> 00:06:27,550
+بطاريات مستخدمة. يمكن استخدامها. بطاريات مستخدمة
+
+88
+00:06:27,550 --> 00:06:29,270
+يمكن استخدامها. بطاريات مستخدمة. يمكن استخدامها
+
+89
+00:06:29,270 --> 00:06:31,470
+بطاريات مستخدمة. يمكن استخدامها. بطاريات مستخدمة
+
+90
+00:06:31,470 --> 00:06:36,270
+يمكن استخدامها. بطاريات مستخدمة. يمكن استخ
+
+91
+00:06:40,810 --> 00:06:45,450
+ثم إزالة المواصفات المكسورة، السلسلة مستعدة للتعامل 
+
+92
+00:06:45,450 --> 00:06:50,150
+معها. مقاطع الميكروسكوبللتحديث الموتولوجيا 
+
+93
+00:06:50,150 --> 00:06:54,150
+والتركيزية سنستخدم الـ Green Filter، الـ Condenser 
+
+94
+00:06:54,150 --> 00:06:59,490
+في موقع PH1 و10X Face Consciousness Objective. تذكر
+
+95
+00:06:59,490 --> 00:07:02,650
+أنه ممكن أيضًا أن تستخدم الـ Fluorescence 
+
+96
+00:07:02,650 --> 00:07:06,870
+موتولوجيا والتركيزية. تستخدم الـ Fluorescence. It is 
+
+97
+00:07:06,870 --> 00:07:09,670
+possible to access the analysis module from the 
+
+98
+00:07:09,670 --> 00:07:12,670
+respective button in results tab or from the icons
+
+99
+00:07:12,670 --> 00:07:16,810
+bar. In this window, the user can choose different 
+
+100
+00:07:16,810 --> 00:07:20,760
+analysis configurations. This is the main analysis 
+
+101
+00:07:20,760 --> 00:07:23,540
+window where the sample information is presented.
+
+102
+00:07:23,540 --> 00:07:28,400
+Press analyze to start. Live image is displayed
+
+103
+00:07:28,400 --> 00:07:34,420
+focus. طبعًا هنا ضاف العينة وشغل الـ microscope وعمل 
+
+104
+00:07:34,420 --> 00:07:38,000
+analysis، فجاب الـ field أخد capture للـ microscope
+
+105
+00:07:38,000 --> 00:07:41,100
+فيما بعد. ببدأ أو الكمبيوتر ببدأ يعد الـ sperm 
+
+106
+00:07:41,100 --> 00:07:47,140
+الموجودة في هذا الـ capture بناء على طبعًا عدد 
+
+107
+00:07:47,140 --> 00:07:53,220
+وParameter معينة وطول وعرض خاصة بالـ head. بعد كده
+
+108
+00:07:53,220 --> 00:07:55,600
+بياخد أكتر من الـ capture وبيقارنهم مع بعض ومع
+
+109
+00:07:55,600 --> 00:08:00,740
+بعض علشان يشوف مين الـ motile ومين الـ مش متايل، sperm
+
+110
+00:08:00,740 --> 00:08:04,220
+fill and start the analysis clicking again the
+
+111
+00:08:04,220 --> 00:08:08,560
+analyze button. main analysis information is always
+
+112
+00:08:08,560 --> 00:08:12,760
+present on this side or capture sequences can be
+
+113
+00:08:12,760 --> 00:08:17,250
+played in the analysis user tab. باستخدام مانيال 
+
+114
+00:08:17,250 --> 00:08:18,930
+النتائج، يمكن للمستخدم أن يختار مقاطع الـ Sperm
+
+115
+00:08:18,930 --> 00:08:22,830
+مختلفة ويقوم بمعرفة أو لا معرفة أي Spermatozoa تم 
+
+116
+00:08:22,830 --> 00:08:25,850
+إظهارها.
+
+117
+00:08:25,850 --> 00:08:33,950
+من 
+
+118
+00:08:33,950 --> 00:08:36,790
+الممكن أيضًا أن تشاهد المعلومات عن واحدة Sperm
+
+119
+00:08:36,790 --> 00:08:42,260
+بمضغط عينيها، وفتح مقاطع الـ Sperm Info. بنقل إلى
+
+120
+00:08:42,260 --> 00:08:44,100
+نتيجة. نتيجة. نتيجة. نتيجة. نتيجة. نتيجة. نتيجة.
+
+121
+00:08:44,100 --> 00:08:46,600
+نتيجة. نتيجة. نتيجة. نتيجة. نتيجة. نتيجة. نتيجة.
+
+122
+00:08:46,600 --> 00:08:49,960
+نتيجة. نتيجة. نتيجة. نتيجة. نتيجة. نتيجة. نتيجة.
+
+123
+00:08:49,960 --> 00:08:55,400
+نتيجة. نتيجة. نتيجة. نتيجة. نتيجة. نتيجة. نتيجة.
+
+124
+00:08:55,400 --> 00:08:55,500
+نتيجة. نتيجة. نتيجة. نتيجة. نتيجة. نتيجة. نتيجة.
+
+125
+00:08:55,500 --> 00:08:55,600
+نتيجة. نتيجة. نتيجة. نتيجة. نتيجة. نتيجة. نتيجة.
+
+126
+00:08:55,600 --> 00:09:05,720
+نتيجة. نتيجة. نتيجة. نتيجة. نتيجة.
+
+127
+00:09:05,720 --> 00:09:10,080
+نتيج
+
+128
+00:09:10,580 --> 00:09:13,360
+أتابع مع المعلومات عن مصادرها الـ Spermatozoon 
+
+129
+00:09:13,360 --> 00:09:28,380
+وخلاصة.
+
+130
+00:09:28,380 --> 00:09:32,040
+مصادر تجارب. تجارب. تجارب. تجارب. تجارب. تجارب. تجارب.
+
+131
+00:09:32,040 --> 00:09:33,260
+تجارب. تجارب. تجارب.
+
+132
+00:09:41,070 --> 00:09:44,770
+هو بسهولة جدًا للوصول إلى مقال التجارب اللي يمكن
+
+133
+00:09:44,770 --> 00:09:55,650
+أن يتم تحميله لأي مصمم التجارب التجاربية.
+
+134
+00:09:55,650 --> 00:09:57,210
+يمكن أن يتم تحميله لأي مصمم التجارب التجاربية.
+
+135
+00:09:57,210 --> 00:10:00,650
+التجاربية. يمكن أن يتم تحميله لأي مصمم التجارب 
+
+136
+00:10:00,650 --> 00:10:02,630
+التجاربية. التجاربية. التجاربية. التجاربية. التجاربية.
+
+137
+00:10:02,630 --> 00:10:03,230
+التجاربية. التجاربية. التجاربية. التجاربية. التجاربية.
+
+138
+00:10:03,230 --> 00:10:03,310
+التجاربية. التجاربية. التجاربية. التجاربية. التجاربية.
+
+139
+00:10:03,310 --> 00:10:03,710
+التجاربية. التجاربية. التجاربية. التجاربية. التجاربية.
+
+140
+00:10:03,710 --> 00:10:09,650
+التجاربية. التجاربية. التجاربية. التجاربية. التجارب. 
+
+141
+00:10:14,380 --> 00:10:18,700
+إذا هذه فكرة الكازا وهي ال computer assisted sperm
+
+142
+00:10:18,700 --> 00:10:22,200
+analysis إنه أنا ك technician ما بشغل شيء بيدي و
+
+143
+00:10:22,200 --> 00:10:25,320
+جرد إن بحضر ال sample من خلال وضع خمسين micro أو 
+
+144
+00:10:25,320 --> 00:10:28,740
+عشرة micro بناء على ال protocol المستخدم وبعدين
+
+145
+00:10:28,740 --> 00:10:31,220
+بضيفه تحت ال fluorescent microscope أو ال phase
+
+146
+00:10:31,220 --> 00:10:34,840
+contrast microscope على عدسة عشرة بعدين بعمل
+
+147
+00:10:34,840 --> 00:10:38,640
+switch on للجهاز وبخليه ياخد capture و 2 و 3 و 4
+
+148
+00:10:39,000 --> 00:10:42,500
+بعدين بدأت على ال analysis عشان يبدأ الجهاز يحلل
+
+149
+00:10:42,500 --> 00:10:46,100
+الصور اللي أخدهم أكثر من مرة بيديني ال utility،
+
+150
+00:10:46,100 --> 00:10:48,520
+بيديني أنواعها، بيديني ال concentration، بيديني ال
+
+151
+00:10:48,520 --> 00:10:51,540
+total count، بيديني ال morphology، بناء على شو أنا
+
+152
+00:10:51,540 --> 00:10:54,720
+بدي براميتر كلها متوفرة، بناء على ال program
+
+153
+00:10:54,720 --> 00:10:59,130
+المستخدم، كل شركة لها program خاص فيهاخدوا بالكوا
+
+154
+00:10:59,130 --> 00:11:03,030
+الكازا ما بيستخدم في الـ routine lab أو اللي بيقول
+
+155
+00:11:03,030 --> 00:11:06,790
+كمية العيلة بتجي لها خمسة، ستة، سبعة، ثمانية في
+
+156
+00:11:06,790 --> 00:11:12,030
+اليوم لأ بيستخدم في المختبرات الكبيرة التي يوجد
+
+157
+00:11:12,030 --> 00:11:16,190
+عندها ضغط كبير من العمل أو مختبرات التي لها علاقة
+
+158
+00:11:16,190 --> 00:11:20,370
+بال research المتعلق في ال anthropology هذه فكرة
+
+159
+00:11:20,370 --> 00:11:25,470
+الكازا الفكرة الثانية التي بتتكلم عنها كيف تعمل
+
+160
+00:11:25,470 --> 00:11:29,850
+evaluation لل sperm DNA طبعا ال sperm عرفته أنه
+
+161
+00:11:29,850 --> 00:11:33,590
+life ال sperm عرفته أنه motile هل ال sperm DNA
+
+162
+00:11:33,590 --> 00:11:37,710
+جيد فيه damage في ال sperm DNA لأنه ممكن ال sperm
+
+163
+00:11:37,710 --> 00:11:43,210
+يكون motile ويكون life ولكن ال capacity تبعته مش
+
+164
+00:11:43,210 --> 00:11:47,350
+هال capacity و ال DNA تبعته صار فيها fragmentation
+
+165
+00:11:47,350 --> 00:11:50,790
+فبالتالي لو عمل fertilization ممكن يؤدي إلى إجهاض
+
+166
+00:11:50,790 --> 00:11:56,480
+الجنين لأنه ما ارتقى إلى الكيف والكم المناسب لإتمام
+
+167
+00:11:56,480 --> 00:12:00,180
+عملية ال fertilization بالشكل المطلوب تحت مصطلح
+
+168
+00:12:00,180 --> 00:12:03,680
+evaluation of sperm DNA damage the maintenance of
+
+169
+00:12:03,680 --> 00:12:08,160
+sperm DNA integrity is vital for fertilized and to
+
+170
+00:12:08,160 --> 00:12:10,440
+transmit the genetic material from one
+
+171
+00:12:10,440 --> 00:12:13,880
+generation to another لأن المادة الوراثية هي عبارة
+
+172
+00:12:13,880 --> 00:12:18,800
+عن جوهر العملية ال fertilization تصير عشان ينقل
+
+173
+00:12:18,800 --> 00:12:23,350
+المادة النووية الخاصة بالأب إلى المادة النووية
+
+174
+00:12:23,350 --> 00:12:26,810
+الخاصة بالأم تكوين الزيجوت إذا كان هذه المادة
+
+175
+00:12:26,810 --> 00:12:29,550
+النووية فيها مشكلة معناه الزيجوت التي اتكونت
+
+176
+00:12:29,550 --> 00:12:34,310
+حتصير فيها مشكلة معناه فرصة ال abortion portion هتزيد ال
+
+177
+00:12:34,310 --> 00:12:37,850
+sperm chromatin undergoes extensive remodeling
+
+178
+00:12:37,850 --> 00:12:43,430
+during spermatogenesis to protect sperm DNA بمعنى
+
+179
+00:12:43,430 --> 00:12:46,590
+آخر إن هذا ال DNA الموجود داخل ال sperm في ال head
+
+180
+00:12:46,590 --> 00:12:50,450
+تاع ال sperm فيه عند ال chromatin الكروماتين الموجود
+
+181
+00:12:50,450 --> 00:12:53,970
+هناك بيصير له عملية كبيرة جدا من الـ remodeling
+
+182
+00:12:53,970 --> 00:12:58,050
+عشان يحافظ على ال sperm و يحمل مادة نوية لخاصة
+
+183
+00:12:58,050 --> 00:13:02,690
+بال sperm من التكسير أو من التلف إذا ما صارش إلها
+
+184
+00:13:02,690 --> 00:13:06,130
+remodeling معناه فيه defect حيصير على صعيد ال
+
+185
+00:13:06,130 --> 00:13:10,410
+sperm DNA in this process most of sperm DNA
+
+186
+00:13:10,410 --> 00:13:14,610
+histone should be replaced with protamine 1 و
+
+187
+00:13:14,610 --> 00:13:19,050
+البروتامين 2 وكمية صغيرة من البروتامين يجب أن
+
+188
+00:13:19,050 --> 00:13:24,530
+تبقى موجودة في ال DNA، في المبالغة هذه العملية
+
+189
+00:13:24,530 --> 00:13:27,550
+مهمة جدا أنه إذا كان عندك كمية كبيرة جدا من
+
+190
+00:13:27,550 --> 00:13:31,550
+البروتامين كبروتين هذا البروتامين سوف يستبدل
+
+191
+00:13:31,550 --> 00:13:35,790
+بالبروتامين 1 وبروتامين 2 ولازم ما يتبقى من
+
+192
+00:13:35,790 --> 00:13:40,310
+البروتامين إلا كمية قليلة جدا جدا جدا لو لم تحدث
+
+193
+00:13:40,310 --> 00:13:44,760
+هذه العملية عملية البروتامين replacement هيكون فيه
+
+194
+00:13:44,760 --> 00:13:47,800
+end effect في الـ structure of DNA في الـ
+
+195
+00:13:47,800 --> 00:13:50,720
+spermatogenesis، معناه الـ sperm لن يؤدي الوظيفة
+
+196
+00:13:50,720 --> 00:13:55,140
+المطلوبة منه if this event don't occur probably
+
+197
+00:13:55,140 --> 00:13:58,240
+endospermatozoa will retain more or save more
+
+198
+00:13:58,240 --> 00:14:01,460
+histone than they should sperm DNA become more
+
+199
+00:14:01,460 --> 00:14:04,060
+sensitive to damaging هذا الكلام اللي حكيته قبل
+
+200
+00:14:04,060 --> 00:14:07,560
+بشوية إنه يجب أن تتم عملية استبدال الهستون
+
+201
+00:14:07,560 --> 00:14:11,300
+بالبروتامين 1 وبروتامين 2 ويبقى الهستون بكمية
+
+202
+00:14:11,300 --> 00:14:14,830
+قليلة جدا جدا جدا داخل ال sperm إذا لم تحدث هذه
+
+203
+00:14:14,830 --> 00:14:18,450
+العملية، معناه إن الـDNA الموجود داخل الـSperm
+
+204
+00:14:18,450 --> 00:14:23,230
+هيكون أكثر حساسية للتلف والتكسير طيب، شو اللي
+
+205
+00:14:23,230 --> 00:14:27,250
+هيكسر؟ وشو هيخليه عرض للتلف؟ بقول الـDNA الـdamage
+
+206
+00:14:27,250 --> 00:14:31,090
+can occur during spermatogenesis أكيد، but
+
+207
+00:14:31,090 --> 00:14:35,610
+also during storage in epididymis or transport from
+
+208
+00:14:35,610 --> 00:14:39,310
+one place to another يعني معنى آخر إن الـSperm
+
+209
+00:14:39,310 --> 00:14:43,950
+طالما خُلق ولم يحدث له عن أي مشكلة خلال عمل التخليق
+
+210
+00:14:43,950 --> 00:14:49,470
+أنه بيكون فيه أمان وفيه مكان مأمون عن المخاطر لأ
+
+211
+00:14:49,470 --> 00:14:53,150
+ممكن يتعرض إلى external factor أو another factor
+
+212
+00:14:53,150 --> 00:14:56,330
+خلال عملية التخزين في ال epididymis أو خلال عملية ال
+
+213
+00:14:56,330 --> 00:14:59,650
+ejaculation أو خلال ال transfer من منطقة إلى منطقة
+
+214
+00:14:59,650 --> 00:15:04,020
+يؤدي إلى تلفه يعني من أشهر العوامل التي تؤدي إلى
+
+215
+00:15:04,020 --> 00:15:07,460
+DNA damage هي عبارة عن Oxidative Stress التي
+
+216
+00:15:07,460 --> 00:15:11,680
+بتسميه OS شو يعني Oxidative Stress؟ ببساطة في
+
+217
+00:15:11,680 --> 00:15:15,160
+أجسامنا في حاجة اسمها Free Radical وفي حاجة اسمها
+
+218
+00:15:15,160 --> 00:15:18,020
+Antioxidant لازم يصير فيه balance ما بين ال
+
+219
+00:15:18,020 --> 00:15:23,200
+antioxidant و ال free radical إذا صار في عندي
+
+220
+00:15:23,200 --> 00:15:26,200
+imbalance ما بين ال free radical و ال antioxidant
+
+221
+00:15:26,200 --> 00:15:30,520
+حيصير عندي حالة بنسميها oxidative stress oxidative
+
+222
+00:15:30,520 --> 00:15:33,460
+stress is one of the most common intrinsic factors
+
+223
+00:15:33,460 --> 00:15:37,640
+leading to sperm DNA damage but it may also result
+
+224
+00:15:37,640 --> 00:15:42,440
+from pathogenic status of the reproductive system
+
+225
+00:15:42,440 --> 00:15:48,610
+برجع بقول مرة ثانية ال Oxidative Stress ينتج من
+
+226
+00:15:48,610 --> 00:15:52,750
+خلال عدم وجود اتزان ما بين كمية ال Antioxidant
+
+227
+00:15:52,750 --> 00:15:56,890
+الموجودة في أجسامنا و ال Free Radical و الأكثر
+
+228
+00:15:56,890 --> 00:16:01,590
+تخصيص عدم وجود اتزان ما بين كمية ال Antioxidant و
+
+229
+00:16:01,590 --> 00:16:04,470
+ال Free Radical الموجودة في seminal fluid فواحد
+
+230
+00:16:04,470 --> 00:16:08,310
+يزيد عن الثاني هيعطيني Oxidative Stress Oxidative
+
+231
+00:16:08,310 --> 00:16:12,620
+Stress يعتبر من أشهر وأكثر الأسباب المسببة إلى
+
+232
+00:16:12,620 --> 00:16:16,800
+تكسير وتلف المادة الوراثية الخاصة بال sperm ولكن
+
+233
+00:16:16,800 --> 00:16:21,940
+هناك عوامل أخرى لها علاقة بالأمراض المتعلقة بال
+
+234
+00:16:21,940 --> 00:16:28,680
+Male Reproductive System حوالي 25% زيادة من ال
+
+235
+00:16:28,680 --> 00:16:33,940
+reactive oxidase species التي سميناها free radical
+
+236
+00:16:33,940 --> 00:16:38,030
+25% increase in seminal معنى ال Reactive Oxygen
+
+237
+00:16:38,030 --> 00:16:43,070
+Species Level مرتبط ب 10% تزيد في عدد ال Sperm
+
+238
+00:16:43,070 --> 00:16:47,190
+DNA Fragmentation يعني عندي لو زاد ال Reactive
+
+239
+00:16:47,190 --> 00:16:53,050
+Oxygen Species التي سميناها Free Radical 25% ستكون
+
+240
+00:16:53,050 --> 00:16:59,970
+سبب في تدمير 10% من ال Sperm DNA تحت مصطلح DNA
+
+241
+00:16:59,970 --> 00:17:04,790
+Fragmentation بمعدل 10% DNA Damage can affect both
+
+242
+00:17:04,790 --> 00:17:09,940
+Nuclear DNA و Mitochondrial DNA يعني بمعنى آخر أن
+
+243
+00:17:09,940 --> 00:17:13,760
+ال Oxidative Stress لن يؤثر فقط على ال Nucleic
+
+244
+00:17:13,760 --> 00:17:16,500
+Acid الموجودة في ال head، في ال Nuclear ولكن
+
+245
+00:17:16,500 --> 00:17:19,040
+هيؤثر أيضًا على ال Nucleic Acid الموجودة في ال
+
+246
+00:17:19,040 --> 00:17:23,300
+Mitochondria Oxidative Stress induced damage to
+
+247
+00:17:23,300 --> 00:17:27,180
+Nuclear DNA may accelerate germ cell apoptosis
+
+248
+00:17:27,180 --> 00:17:30,300
+leading to decline in sperm production and
+
+249
+00:17:30,300 --> 00:17:35,080
+consequently decrease sperm count in ejaculation لو
+
+250
+00:17:35,080 --> 00:17:38,440
+حصل فيه stress أكسدة سيدمر ال DNA الموجودة في
+
+251
+00:17:38,440 --> 00:17:42,120
+نواة ال sperm فبالتالي سيتعرض ال sperm إلى
+
+252
+00:17:42,120 --> 00:17:46,120
+Apoptosis معناه سيصير نقصان في عدد ال sperm
+
+253
+00:17:46,120 --> 00:17:50,760
+الموجودة في ال ejaculation معناه في عندي ببساطة جدا
+
+254
+00:17:50,760 --> 00:17:54,640
+نقصان في كمية ال sperm المخلقة معناه في عندي نقصان
+
+255
+00:17:54,640 --> 00:17:58,780
+في ال sperm count يعني one step another step go to
+
+256
+00:17:58,780 --> 00:18:02,080
+another step a positive sum study
+
+257
+00:18:13,420 --> 00:18:18,640
+معناه زيادة ال sperm DNA fragmentation متعلق
+
+258
+00:18:18,640 --> 00:18:22,440
+بزيادة ال abnormal في ال sperm morphology و
+
+259
+00:18:22,440 --> 00:18:26,820
+بالذات في ال sperm ثاني في دراسة أخرى قالت إنه في
+
+260
+00:18:26,820 --> 00:18:30,800
+عندي higher incidence of aneuploidy in man in men
+
+261
+00:18:30,800 --> 00:18:34,520
+or males with high sperm DNA fragmentation ال
+
+262
+00:18:34,520 --> 00:18:40,120
+incidence تبع الانبلويدي في الذكور بيزيد لو زاد
+
+263
+00:18:40,120 --> 00:18:46,160
+عندي ال DNA fragmentation هذه شكل آخر ودراسة أخرى
+
+264
+00:18:46,160 --> 00:18:50,800
+وجدت أن ال higher incidence of aneuploidy في الذكور
+
+265
+00:18:50,800 --> 00:18:58,480
+مرتبط بال high sperm DNA fragmentation صورة توضح
+
+266
+00:18:58,480 --> 00:19:02,580
+الكلام التي اتكلمنا عنه هذا ال sperm في أعلى ال
+
+267
+00:19:02,580 --> 00:19:06,000
+slide sperm، normal sperm بيصير له capacitation
+
+268
+00:19:06,000 --> 00:19:09,260
+بيصير عندي acrosome reaction بيصير عندي
+
+269
+00:19:09,260 --> 00:19:12,880
+hyperactivation يعني بيصير عندي fertilization ما
+
+270
+00:19:12,880 --> 00:19:15,960
+بيصير fertilization إلا إذا صارت capacitation وهو
+
+271
+00:19:15,960 --> 00:19:19,900
+تحول ال sperm إلى completely mature sperm بعدين
+
+272
+00:19:19,900 --> 00:19:23,960
+بيصير acrosome reaction من خلال اتصال ال sperm مع
+
+273
+00:19:23,960 --> 00:19:26,440
+ال receptor الموجودة في zona pellucida رقم 3
+
+274
+00:19:26,440 --> 00:19:30,430
+وإفراز إنزيماته الهاضمة بعدين بيصير ال
+
+275
+00:19:30,430 --> 00:19:33,950
+hyperactivation وهي عبارة عن زيادة الحركة مما
+
+276
+00:19:33,950 --> 00:19:36,630
+يسمح لل sperm باختراق ال oocyte بيصير
+
+277
+00:19:36,630 --> 00:19:40,510
+fertilization تصور صار عندك imbalance ما بين ال
+
+278
+00:19:40,510 --> 00:19:43,710
+free radical reactive oxygen species و ال
+
+279
+00:19:43,710 --> 00:19:47,790
+antioxidant هتعطيلي حالة بنسميها oxidative stress
+
+280
+00:19:47,790 --> 00:19:51,570
+هذا ال oxidative stress مصدرها قد يكون أسبابها 
+
+281
+00:19:51,570 --> 00:19:55,830
+خارجية زي الـ smoking زي الـ radiation زي الكحول و
+
+282
+00:19:55,830 --> 00:19:59,400
+زي المواد التكسيدية وقد تكون داخلية زي الـ
+
+283
+00:19:59,400 --> 00:20:04,060
+Varicosel دوال الخصية زي الـ Leukocyte زيادة في 
+
+284
+00:20:04,060 --> 00:20:06,700
+عدد Leukocyte يعني الـ inflammation وزي الـ
+
+285
+00:20:06,700 --> 00:20:11,600
+immature spermatozoa خدوا بالكم النقطة التهاب 
+
+286
+00:20:11,600 --> 00:20:16,460
+وزيادة عدد الحيوانات المنوية الغير ناضجة يؤدي إلى 
+
+287
+00:20:16,460 --> 00:20:20,080
+زيادة عدد الرُس زيادة عدد الرُس تعتبر من أهم
+
+288
+00:20:20,080 --> 00:20:23,840
+العوامل التي تؤدي إلى الـ oxidative stress طب صار
+
+289
+00:20:23,840 --> 00:20:27,890
+في oxidative stress إيش هيسوي؟ هيعمل على تعطيل الـ
+
+290
+00:20:27,890 --> 00:20:31,410
+physiological rules الخاصة بالـ sperm هتعطل
+
+291
+00:20:31,410 --> 00:20:34,810
+الـ capacitation، هتعطل الـ acrosome reaction، هتعطل
+
+292
+00:20:34,810 --> 00:20:38,070
+الـ hyperactivity، يعني مافيه fertilization أضف إلى
+
+293
+00:20:38,070 --> 00:20:42,310
+ذلك، هتعمل apoptosis، هتعمل DNA damage على الـ صحيح
+
+294
+00:20:42,310 --> 00:20:47,590
+DNA، هتعمل مشاكل في الـ lipid protein الموجودة
+
+295
+00:20:47,850 --> 00:20:52,730
+في الـ peroxidation الخاصة بالـ sperm فبالتالي الـ 
+
+296
+00:20:52,730 --> 00:20:57,070
+infertility بتكون أقرب في هذه الحالة إلى الذكورة
+
+297
+00:20:57,070 --> 00:21:01,030
+Alteration in mitochondria sperm DNA mainly led to
+
+298
+00:21:01,030 --> 00:21:04,470
+impaired mitochondrial function those resulting in
+
+299
+00:21:04,470 --> 00:21:08,030
+the homotility abnormality, hyperactivity
+
+300
+00:21:08,030 --> 00:21:11,310
+abnormality, inability to fertilization يعني بمعنى
+
+301
+00:21:11,310 --> 00:21:16,030
+آخر ليس الخطر مرتبط بالدمج في الـ sperm nuclear DNA
+
+302
+00:21:16,510 --> 00:21:19,990
+ولكن لو حد رزد دمش في الـ sperm mitochondrial DNA، هذا
+
+303
+00:21:19,990 --> 00:21:22,670
+معناه هيوقف الـ motility، هتكون الـ motility غير 
+
+304
+00:21:22,670 --> 00:21:28,610
+متكافئة، غير سليمة، غير صحيحة، غير مطلوبة الـ
+
+305
+00:21:28,610 --> 00:21:32,570
+hyperactivity هيصير فيها defect، هيصير غير قادر 
+
+306
+00:21:32,570 --> 00:21:35,970
+على الـ fertilization زي ما شفنا في الـ slide السابق
+
+307
+00:21:45,480 --> 00:21:54,500
+الفرصة اللي تبقى
+
+308
+00:21:54,500 --> 00:21:58,060
+محدودة
+
+309
+00:21:58,060 --> 00:22:01,000
+في الـ sperm DNA لإصلاح المزيد من المزيد من المزيد
+
+310
+00:22:01,000 --> 00:22:03,160
+من المزيد من المزيدو Damage في الـ DNA معناه 
+
+311
+00:22:03,160 --> 00:22:06,260
+البروتينات الموجودة في الـ Sperm هتفقد وظيفتها 
+
+312
+00:22:06,260 --> 00:22:10,200
+معناه الـ Sperm هيفقد وظيفته The available method
+
+313
+00:22:10,200 --> 00:22:13,280
+we can use it to detect the DNA damage
+
+314
+00:22:13,280 --> 00:22:17,080
+fragmentation or apoptosis عندي تلت طرق Measured
+
+315
+00:22:17,080 --> 00:22:22,400
+DNA damage by incorporating DNA probe Measured the
+
+316
+00:22:22,400 --> 00:22:26,580
+sensitivity of DNA to denaturation indirect
+
+317
+00:22:26,580 --> 00:22:30,300
+measures of level chromatin compaction هذه التلت 
+
+318
+00:22:30,300 --> 00:22:34,640
+عوامل أساسية هناخد تنتين مهمين جدا و لازم يتم 
+
+319
+00:22:34,640 --> 00:22:39,080
+إجراءهم في مراكز التوضيح الصناعي So what is the
+
+320
+00:22:39,080 --> 00:22:42,620
+type of DNA damage؟ according to the type بقدر
+
+321
+00:22:42,620 --> 00:22:46,380
+أحدد الـ test أول حاجة DNA fragmentation والـ DNA 
+
+322
+00:22:46,380 --> 00:22:50,380
+Fragmentation في عوامل أخرى كثيرة تساهم فيه منها
+
+323
+00:22:50,380 --> 00:22:53,220
+الـ Intrinsic أو الـ Extrinsic Factor الـ
+
+324
+00:22:53,220 --> 00:22:56,600
+Intrinsic Factor التي تؤدي إلى DNA Fragmentation
+
+325
+00:22:56,600 --> 00:23:01,980
+والذي يعتبر أحد أنواع الـ DNA Damaged Epitosis and
+
+326
+00:23:01,980 --> 00:23:05,620
+Oxidative Stress وحكينا عنها الـ Defect في الـ 
+
+327
+00:23:05,620 --> 00:23:08,140
+Protamination وهي عملية استبدال الـ Histone
+
+328
+00:23:08,140 --> 00:23:13,220
+بالبروتامين لأن وجود البروتامين مهم جدا لحماية DNA
+
+329
+00:23:13,220 --> 00:23:17,480
+of spermatozoa Insufficient chromatin remodeling
+
+330
+00:23:17,480 --> 00:23:20,780
+خلل في الـ spermatogenesis إذا الأربع عوامل
+
+331
+00:23:20,780 --> 00:23:26,400
+الأساسية تصنف intrinsic factor تعمل على و تساهم في
+
+332
+00:23:26,400 --> 00:23:30,420
+حدوث الـ DNA fragmentation الذي يعتبر أحد أنواع
+
+333
+00:23:30,420 --> 00:23:33,830
+الـ DNA damage العوامل الأخرى بنسميها external
+
+334
+00:23:33,830 --> 00:23:38,530
+factors زي الـ life style زي الـ diet و الـ drug
+
+335
+00:23:38,530 --> 00:23:43,110
+consuming و الـ tobacco، cigarette smoking، الشيشة، 
+
+336
+00:23:43,110 --> 00:23:46,330
+الـ advancing age زيادة العمر، الـ environment
+
+337
+00:23:46,330 --> 00:23:50,770
+exposure زي الـ pesticide و الـ pollution، بعض الـ
+
+338
+00:23:50,770 --> 00:23:53,430
+medical history زي الـ inflammation و الفارقوسيل و
+
+339
+00:23:53,430 --> 00:23:58,420
+الـ cancer دول الأربع يعتبروا external factor تساهم
+
+340
+00:23:58,420 --> 00:24:02,600
+في إحداث DNA fragmentation الذي يعتبر أحد أنواع
+
+341
+00:24:02,600 --> 00:24:08,360
+الـ DNA damage صورة بتوضح الكلام اللي احنا اتكلمنا
+
+342
+00:24:08,360 --> 00:24:14,220
+عنه في sperm and sperm DNA damage بيصير بفعل أول
+
+343
+00:24:14,220 --> 00:24:18,480
+حاجة الـ aging advanced aging infection cancer
+
+344
+00:24:18,480 --> 00:24:24,360
+toxic material radiation pollution Caffeine Intake
+
+345
+00:24:24,360 --> 00:24:30,100
+Body Mass Index Malnutrition Poor Diet Alcohol
+
+346
+00:24:30,100 --> 00:24:34,560
+Stress Smoking Increase in testicular temperature
+
+347
+00:24:34,560 --> 00:24:37,360
+و البركوسيلة عشان كده الناس اللي بتشتغل في المخابز 
+
+348
+00:24:37,360 --> 00:24:40,520
+القديمة و الناس اللي بتشتغل في مصانع الاسفنج و
+
+349
+00:24:40,520 --> 00:24:43,560
+بتتعرض لكمية كبيرة جدا من الحرارة بتكون أقرب للـ
+
+350
+00:24:43,560 --> 00:24:48,700
+infertility بفيها الحدوث اتدمج في الـ DNA طبعا مهم
+
+351
+00:24:48,700 --> 00:24:52,640
+جدا نعرف على هذه العوامل اللي قسمها Intrinsic
+
+352
+00:24:52,860 --> 00:24:57,400
+و extrinsic factor أكثر انتشاراً الـ extrinsic 
+
+353
+00:24:57,400 --> 00:25:01,860
+factor هي الأكثر انتشارا من أشهر الفحوصات التي
+
+354
+00:25:01,860 --> 00:25:05,860
+يمكن أن تستخدم بتحديد الـ DNA fragmentation هي عبارة 
+
+355
+00:25:05,860 --> 00:25:09,400
+عن فحص بنسميه Tunnel فحص Tunnel هو عبارة عن
+
+356
+00:25:09,400 --> 00:25:12,800
+Microscopic Detection للأبيبتوسس فحص Tunnel هو
+
+357
+00:25:12,800 --> 00:25:17,240
+عبارة عن Microscopic Detection للأبيبتوسس شو الـ
+
+358
+00:25:17,240 --> 00:25:21,320
+مبدأ الأساسي الخاص فيه؟ ببساطة جدا، this assay
+
+359
+00:25:21,320 --> 00:25:27,580
+is based on the labeling of 3'3-hydroxyl-M of the
+
+360
+00:25:27,580 --> 00:25:32,770
+fragmented DNA with fluorescence dUTP catalyzed by
+
+361
+00:25:32,770 --> 00:25:36,930
+terminal dUTP يعني بمعنى آخر، لو أنا فيه عندي
+
+362
+00:25:36,930 --> 00:25:40,670
+الـ DNA الخاص بالـ Spermatozoa الموجودة في الهدف، لو
+
+363
+00:25:40,670 --> 00:25:46,410
+صار لها Fragmentation، هيصير عندي Free OH الموجودة على 
+
+364
+00:25:46,410 --> 00:25:50,770
+الـ 3 Prime الـ Free OH الموجودة على الـ 3 Prime
+
+365
+00:25:50,770 --> 00:25:57,390
+تعتبر كمكان مميز ومكان as mark indicator على وجود 
+
+366
+00:25:57,390 --> 00:26:01,190
+الـ Fragmentation ففي صبغة ممكن ترتبط مع هذا
+
+367
+00:26:01,190 --> 00:26:06,870
+المكان و تعطيني fluorescent dye الـ dUTP مميز مع 
+
+368
+00:26:06,870 --> 00:26:10,050
+الـ fluorescent probe نستطيع اتجاهه باستخدام
+
+369
+00:26:10,050 --> 00:26:13,910
+ميكروسكوب fluorescent أو فلو سايتوميتر الوصول
+
+370
+00:26:13,910 --> 00:26:18,150
+للسيجنال الطبيعي سيكون مرتبط بقيمة الـ Strand
+
+371
+00:26:18,150 --> 00:26:23,930
+Breaks والتي ستتفكر كمية الـ sperm DNA باختصار
+
+372
+00:26:23,930 --> 00:26:28,850
+شديد الـ Tunnel هو عبارة عن تحس يستخدم لقياس مدى
+
+373
+00:26:28,850 --> 00:26:32,310
+الـ Apoptosis أو الـ DNA Fragmentation في الـ 
+
+374
+00:26:32,310 --> 00:26:36,870
+spermatozoa DNA من خلال أن في مادة موجودة في هذا
+
+375
+00:26:36,870 --> 00:26:42,560
+الـ reagent لها قابلية للارتباط مع الـ OH الـ Free
+
+376
+00:26:42,560 --> 00:26:46,440
+الموجودة على الـ 3 Prime من أين أجت أن عند Double
+
+377
+00:26:46,440 --> 00:26:50,960
+Strand DNA صارها Fragmentation أدت إلى وجود Free
+
+378
+00:26:50,960 --> 00:26:55,280
+OH موجودة على الـ 3 Prime ترتبط بهذه المادة المادة
+
+379
+00:26:55,280 --> 00:27:02,000
+هذه مرتبطة بـ Fluorescent Probe إذا عرضت للـ UV أو 
+
+380
+00:27:02,000 --> 00:27:06,220
+لـ Fluorescent Microscope أو لـ Fluorescent Microscope هشوفها
+
+381
+00:27:06,220 --> 00:27:10,320
+تحت الميكروسكوب فممكن أقرأها ببساطة جدا على هيئة
+
+382
+00:27:10,320 --> 00:27:15,640
+percentage في علاقة ما بين عدد الـ indicator التي
+
+383
+00:27:15,640 --> 00:27:19,320
+تظهر عدد الـ flow التي تظهر عدد الـ light التي 
+
+384
+00:27:19,320 --> 00:27:21,920
+ignition light التي تظهر الـ emission light التي
+
+385
+00:27:21,920 --> 00:27:28,860
+تظهر و نسبة الـ apoptosis كل ما زاد .. كل ما زاد الـ 
+
+386
+00:27:28,860 --> 00:27:34,020
+signal معناه في عندي عدد كبير من الـ DNA apoptosis
+
+387
+00:27:34,020 --> 00:27:38,550
+أو الـ DNA fragmentation صورة بتوضح الكلمة ده هاي في
+
+388
+00:27:38,550 --> 00:27:42,550
+عندي sperm double strand يعني صار في عندي break في
+
+389
+00:27:42,550 --> 00:27:46,310
+الـ double strand أدت إلى تكوين OH3 على الـ 3 prime
+
+390
+00:27:46,310 --> 00:27:52,050
+عملتلها mixing بالـ TUNEL kit فلجيت أنه في عند الـ
+
+391
+00:27:52,050 --> 00:27:57,010
+TdT enzyme ارتبط فيها ومربوط بالـ Fluoro Scan لو
+
+392
+00:27:57,010 --> 00:27:59,630
+عرضته لـ flow cytometer أو fluorescent microscope
+
+393
+00:27:59,630 --> 00:28:03,150
+هتعطيني emission لونه green الـ emission أو light
+
+394
+00:28:03,150 --> 00:28:07,610
+لونه green light لونه green يتناسب تناسباً طردياً
+
+395
+00:28:07,610 --> 00:28:11,470
+مع عدد الحيوانات المنوية التي بها defect أو بها
+
+396
+00:28:11,470 --> 00:28:17,470
+apoptosis الصورة أفضل دالين هي عندي صورة الـ 
+
+397
+00:28:17,470 --> 00:28:24,130
+background black وفي عندي لونين لون pale green
+
+398
+00:28:24,130 --> 00:28:29,090
+فاتح أخضر فاتح و لون dark green الـ dark green
+
+399
+00:28:29,090 --> 00:28:31,930
+معناه tone positive ماذا يعني الـ tone الـ 
+
+400
+00:28:31,930 --> 00:28:35,170
+positive؟ معناه إنه في صار في عندي Fragmentation 
+
+401
+00:28:35,170 --> 00:28:40,070
+ارتبطت الـ probe مع الـ OH الـ 3 الموجودة على الـ 3 
+
+402
+00:28:40,070 --> 00:28:44,810
+prime معناه إذا عرضتها لفلورسانت مايكروسكوب أو
+
+403
+00:28:44,810 --> 00:28:49,570
+الـ FluoroScan هيعطيني signal light لونه green كل ما
+
+404
+00:28:49,570 --> 00:28:53,110
+زاد الـ intensity للـ green color معناه في عندي كمية 
+
+405
+00:28:53,110 --> 00:28:56,610
+Fragmentation أعلى أما الـ pale color معناه الـ tone
+
+406
+00:28:56,610 --> 00:28:59,740
+الـ negative يعني مافي عندي Fragmentation هنا ما في 
+
+407
+00:28:59,740 --> 00:29:04,200
+OH3 يرتبط فيها الـ probe هنا عشان كده بقوللي
+
+408
+00:29:04,200 --> 00:29:06,740
+TUNEL Assay for Detection of Sperm DNA
+
+409
+00:29:06,740 --> 00:29:13,060
+Fragmentation Under Fluorescent Microscope الـ
+
+410
+00:29:13,060 --> 00:29:16,640
+Normal DNA هيديني الـ Light Green عشان كده بسميه 
+
+411
+00:29:16,640 --> 00:29:19,920
+TUNEL Negative بينما الـ Damaged DNA أو الـ 
+
+412
+00:29:19,920 --> 00:29:24,940
+Apoptosis Sperm هيعطيني Bright أو Dark Green وهو
+
+413
+00:29:24,940 --> 00:29:29,740
+عبارة عن الـ TUNEL الـ Positive عن الـ TUNEL
+
+414
+00:29:29,740 --> 00:29:34,860
+positive طبعاً هذا هي عبارة عن الفكرة ما بين الـ
+
+415
+00:29:34,860 --> 00:29:38,160
+TUNEL positive والـ TUNEL الـ negative الخاصة
+
+416
+00:29:38,160 --> 00:29:42,120
+بقياس الـ Fragmentation Sperm يعني Fragmentation أو
+
+417
+00:29:42,120 --> 00:29:50,660
+Sperm Apoptosis سنكتفي 
+
+418
+00:29:50,660 --> 00:29:55,000
+بهذا القدر من المعلومات في هذه المحاضرة على أمل أن
+
+419
+00:29:55,000 --> 00:29:59,280
+نتقي في المحاضرة القادمة إن شاء الله Dom Tom في حفظ 
+
+420
+00:29:59,280 --> 00:29:59,420
+الله 
+
+Okay, please provide the Arabic/English lecture transcript that you would like me to review and correct for typos and grammatical errors. 
+
+I will ensure that I:
+
+* **Focus on typos and grammar only.**
+* **Preserve the original Arabic and English dialect and grammar.**
+* **Maintain the original meaning and style of the text.**
+* **Provide the corrected transcript ONLY in the same format as the input.** 
+* **Keep the text in the original language.**
+
+I am ready to assist you with correcting your lecture transcript. Just paste the text and I will get to work! 
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/KDv30k-n6FE_postprocess.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/KDv30k-n6FE_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..286e11761dfc2002296ac68b0c6662d563eca9a6
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/KDv30k-n6FE_postprocess.srt
@@ -0,0 +1,3668 @@
+1
+00:00:01,450 --> 00:00:05,330
+باسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:05,330 --> 00:00:10,690
+المرسلين سيدنا محمد وعلى آله وصحبه أجمعين طلابنا
+
+3
+00:00:10,690 --> 00:00:15,030
+الأعزاء أرجو من الله الكريم أن تكونوا جميعا بخير
+
+4
+00:00:15,030 --> 00:00:20,110
+اليوم سوف نستكمل ما بدأنا فيه في المحاضرة السابقة
+
+5
+00:00:20,110 --> 00:00:25,170
+التي كانت بعنوان الحقن المجهري intracytoplasmic
+
+6
+00:00:25,170 --> 00:00:30,460
+sperm injection تكلمنا في المحاضرة السابقة عنأهم
+
+7
+00:00:30,460 --> 00:00:35,000
+الخطوات المتبعة في الحقن المجهري والتي تتمثل فيه
+
+8
+00:00:35,000 --> 00:00:39,740
+آلية تحضير الأطباق الخاصة بالحقن كيف يتم تحميل
+
+9
+00:00:39,740 --> 00:00:45,140
+الجميطات الأنثوية والذكرية داخل الطبق مما تتكون
+
+10
+00:00:45,140 --> 00:00:50,700
+هذه الأطباق من أوصاد زراعية كيف يمكن استخدام الزيت
+
+11
+00:00:50,700 --> 00:00:54,840
+من أجل تغطية هذه القطارات الموضوعة في ال injection
+
+12
+00:00:54,840 --> 00:01:00,220
+dish أو ال petri dishكيف يتم عمل immobilization
+
+13
+00:01:00,220 --> 00:01:03,940
+للـ spermatozoa من أجل يقاف قدرتها على الحركة
+
+14
+00:01:03,940 --> 00:01:08,800
+واستخدامها في عملية الحقن؟ كيف يمكن التفريط بين ال
+
+15
+00:01:08,800 --> 00:01:13,820
+spermatozoa الميت والحي؟ وبناء عليه نستطيع أن نقول
+
+16
+00:01:13,820 --> 00:01:17,880
+هذا الحيوان المنوي يصلح لعملية الحقن أم لا يصلح
+
+17
+00:01:17,880 --> 00:01:22,760
+اليوم سوف نستكمل باقي ما تعلق بهذا الموضوع في
+
+18
+00:01:22,760 --> 00:01:28,410
+محاضرة واحدة فقط لا غير لن نقسم المحاضرةأول عنوان
+
+19
+00:01:28,410 --> 00:01:32,790
+سوف نتحدث فيه هو عبارة عن فشل عملية الحقن المجهري
+
+20
+00:01:32,790 --> 00:01:40,210
+ثم سوف نتحدث عن فشل نتائج الحقن المجهري المعروف أن
+
+21
+00:01:40,210 --> 00:01:45,030
+الحقن المجهري نتيجته انقسام في البويضة المخصبة لكي
+
+22
+00:01:45,030 --> 00:01:54,610
+تصبح خليتين أو 4 ثم 8 ثم 16ثم 32 لكي تصلح وتصل إلى
+
+23
+00:01:54,610 --> 00:02:00,090
+اللحظة التي يمكن أن يتم إرجاعها إلى رحم السيدة من
+
+24
+00:02:00,090 --> 00:02:05,030
+أجل عمل implementation واستكمال عملية تكوين الجنين
+
+25
+00:02:05,030 --> 00:02:12,050
+ولكن Exifailure موضوع مهم جدا لا يمكن بشكل من
+
+26
+00:02:12,050 --> 00:02:15,650
+الأشكال أن نقول عملية الحقن ال major عملية ناجحة
+
+27
+00:02:15,650 --> 00:02:21,050
+إلا إذا حصلنا على true baby فبالتاليفي عندي نجاح
+
+28
+00:02:21,050 --> 00:02:26,170
+مؤقت يشمل نجاح حملية الحقل وانقسام البويضة المخصبة
+
+29
+00:02:26,170 --> 00:02:30,190
+في المختبر هذه نسبة نجاح معينة تعتبر theoretical
+
+30
+00:02:30,190 --> 00:02:35,790
+إلى حد ما ولكن النجاح الحقيقي هو عبارة عن إرجاع
+
+31
+00:02:35,790 --> 00:02:39,950
+البويضة المخصبة إلى رحم الأنثى ثم عمل implantation
+
+32
+00:02:39,950 --> 00:02:44,990
+وتكوين جنين ثم بعد نهاية 9 شهور الحصول على طفل
+
+33
+00:02:44,990 --> 00:02:49,770
+حقيقي على قيد الحياةكدا بتكون عملية الحقن المجهري
+
+34
+00:02:49,770 --> 00:02:55,290
+عملية ناجحة و بقدر أحقق نسبة و أحسب نسبة نجاح كل
+
+35
+00:02:55,290 --> 00:03:02,470
+ألف حالة جديش بحصل على theoretical إجزي true
+
+36
+00:03:02,470 --> 00:03:07,510
+process success process و جديش بحصل على success
+
+37
+00:03:07,510 --> 00:03:15,210
+process من ال إجزي plasma injection كعملية ناجحة
+
+38
+00:03:15,210 --> 00:03:18,480
+فبالتالي في عندينجاح حقيقي بالحصول على true pp
+
+39
+00:03:18,480 --> 00:03:23,200
+ونجاح إلى حد ما نظري مؤقت بنجاح حملية الحقن
+
+40
+00:03:23,200 --> 00:03:27,160
+المجهري من خلال القسام البويضة المخصبة في المختبر
+
+41
+00:03:27,160 --> 00:03:31,600
+فبالتالي إلى حد ما معدل الـdegenerated of oocyte
+
+42
+00:03:31,600 --> 00:03:38,460
+بعد الإجزي بتروح ما بين 1 إلى 2، 3، أقل من 3 يعني
+
+43
+00:03:38,460 --> 00:03:43,340
+1 إلى 3 كحد أعلى ان في عندي من كل .. من 100 طبعا
+
+44
+00:03:43,340 --> 00:03:48,270
+.. في عندي من كلميت بويضة مخصبة بيصير failure إلها
+
+45
+00:03:48,270 --> 00:03:51,910
+وما بتكمل عملية انقسام وهذا بنسميه Oocyte
+
+46
+00:03:51,910 --> 00:03:57,350
+Degradation after Exit طبعا ال Exit Failure كان بي
+
+47
+00:03:57,350 --> 00:04:02,150
+occur in three different level أول level ممكن يحدث
+
+48
+00:04:02,150 --> 00:04:05,570
+فيه failure لل Exit Process هو عبارة عن مرحلة
+
+49
+00:04:05,570 --> 00:04:09,550
+الحصول على ال spermatozoonوخاصة إذا كان ال male
+
+50
+00:04:09,550 --> 00:04:13,110
+يعاني من obstructive azospermia عنده obstructive
+
+51
+00:04:13,110 --> 00:04:16,990
+azospermia مش هيقدر يجيب عينة مافي عنده
+
+52
+00:04:16,990 --> 00:04:20,830
+ejaculation فهيضطر الطبيب يعمل testicular biopsy
+
+53
+00:04:20,830 --> 00:04:24,510
+اللي سمناها TSA أو PSA تصور إن الطبيب عمل
+
+54
+00:04:24,510 --> 00:04:29,030
+testicular biopsy ومالاجعش فيه عندي أو عند هذا ال
+
+55
+00:04:29,030 --> 00:04:32,850
+male أو عند هذه الحالة وانا بشغل مافي عندي
+
+56
+00:04:32,850 --> 00:04:36,630
+spermatozoaما في Anti-Spermatozoa هيه اللي جاء إلى
+
+57
+00:04:36,630 --> 00:04:41,910
+عمل cancellation أو cancel للـXE process فبالتالي
+
+58
+00:04:41,910 --> 00:04:46,710
+فشلت عملية الحقن المجهري بسبب عدم القدرة على حصول
+
+59
+00:04:46,710 --> 00:04:51,210
+على عين Anti-Spermatozoa من هذا الشخص المصاب بالـ
+
+60
+00:04:51,210 --> 00:04:55,290
+Obstructive AzospermiaOn the other hand, as may be
+
+61
+00:04:55,290 --> 00:05:00,010
+expected, sperm are recovered in virtually all
+
+62
+00:05:00,010 --> 00:05:03,090
+attempts involved man with obstructive aspermia
+
+63
+00:05:03,090 --> 00:05:05,370
+لأن الوضع الطبيعي بيقولك طالما عنده obstructive
+
+64
+00:05:05,370 --> 00:05:09,450
+aspermia، إيه المفروض؟من المصنع وهو ال testis
+
+65
+00:05:09,450 --> 00:05:12,530
+تشتغل بشكل طبيعي يعني لو أنا أعملت له testicular
+
+66
+00:05:12,530 --> 00:05:17,070
+biopsy المفروض ألاجه أن يكون عنده spermatozoa أصور
+
+67
+00:05:17,070 --> 00:05:21,050
+أن هذا الطبيب عمل testicular biopsy وما وجد وما
+
+68
+00:05:21,050 --> 00:05:23,910
+وجد عند هذا المريض أي نوع من أنواع ال spermatozoa
+
+69
+00:05:23,910 --> 00:05:27,330
+فبالتالي فشلت عملية الحقن المجهري إذن هذه أول
+
+70
+00:05:27,330 --> 00:05:31,550
+مرحلة من مراحل فشل الحقن المجهري التي يمكن أن تحدث
+
+71
+00:05:31,550 --> 00:05:35,700
+المرحلة التانيةfailure of fertilized after exit في
+
+72
+00:05:35,700 --> 00:05:40,260
+عندك كمية كافية من ال spermatozoa ال spermatozoa
+
+73
+00:05:40,260 --> 00:05:43,280
+morphological normal ولكن functional أنا لا أدري
+
+74
+00:05:43,280 --> 00:05:47,380
+فبالتالي حصلت على ال spermatozoa ولكن هذه ال
+
+75
+00:05:47,380 --> 00:05:52,200
+spermatozoa فشلت في إتمام عملية التلقيح خدوا بالكم
+
+76
+00:05:52,200 --> 00:05:56,140
+النقطة المهمة التلقيح بالمستوى و بالمعروف المبدأي
+
+77
+00:05:56,140 --> 00:06:00,080
+هو اختراق ال spermatozoa للبوايدة ولكن لكي أكتمل
+
+78
+00:06:00,080 --> 00:06:04,070
+التلقيح و أحكي أن في عنديtrue fertilization لازم
+
+79
+00:06:04,070 --> 00:06:06,630
+يصير اندماج ما بين النواء الذكرية مع النواء
+
+80
+00:06:06,630 --> 00:06:10,130
+الأنثوية فبالتالي بصير أقدر أقول أنه صار عندي
+
+81
+00:06:10,130 --> 00:06:14,490
+fertilization success process not failure of
+
+82
+00:06:14,490 --> 00:06:17,970
+fertilization مافي عندي فشل في ال fertilization ..
+
+83
+00:06:17,970 --> 00:06:20,570
+في ال fertilization ولكن ال fertilization نجحت
+
+84
+00:06:20,570 --> 00:06:23,710
+بشكل كامل the reasons for this few failures
+
+85
+00:06:23,710 --> 00:06:27,730
+remained unclear until now but we can summarize
+
+86
+00:06:27,730 --> 00:06:34,140
+this topic in differentLiver for example بور sperm
+
+87
+00:06:34,140 --> 00:06:39,000
+viability or a problem in the penetration of
+
+88
+00:06:39,000 --> 00:06:46,520
+oocyte ممكن انا يكون عندي مشكلة في عملية ال
+
+89
+00:06:46,520 --> 00:06:49,200
+viability بتاعة ال sperm metazoa فبالتالي كل sperm
+
+90
+00:06:49,200 --> 00:06:53,160
+dead morphological okay طبيعي 100% ولكن not life
+
+91
+00:06:53,160 --> 00:06:57,220
+فبالتالي هتفشل عملية ال fertilization ال sperm
+
+92
+00:06:57,220 --> 00:07:01,990
+metazoa lifeولكن ال oocyte مش mature فبالتالي
+
+93
+00:07:01,990 --> 00:07:06,610
+هتفشل عملية ال fertilization
+
+94
+00:07:06,610 --> 00:07:10,930
+نجحت عملية الاختراق ولكن لم تنجح عملية الدمش بين
+
+95
+00:07:10,930 --> 00:07:15,220
+النويتين فبالتالي فشلت عملية ال fertilizationفي
+
+96
+00:07:15,220 --> 00:07:18,400
+بعض الأحيان بعض الذكور في عندهم مشكلة بيسميها
+
+97
+00:07:18,400 --> 00:07:23,080
+Acrosomalis و ال Acrosomalis بمصطلح آخر بيسموه
+
+98
+00:07:23,080 --> 00:07:27,260
+Global Zospermic Global Zospermic Spermatozoa
+
+99
+00:07:27,260 --> 00:07:32,000
+cannot be achieved Sangam Sangam even after
+
+100
+00:07:32,000 --> 00:07:35,200
+existence شو يعني Sangam؟ Sangam معناه اندماج يعني
+
+101
+00:07:35,200 --> 00:07:39,020
+okay هذا الذكر عنده spermatozoa spermatozoa طبيعية
+
+102
+00:07:39,020 --> 00:07:42,780
+morphological functional مافي عنده أي مشكلة ولكن
+
+103
+00:07:42,780 --> 00:07:48,130
+هذه ال spermatozoaوهذه النطف لا تستطيع أن تصل إلى
+
+104
+00:07:48,130 --> 00:07:51,850
+المرحلة المطلوبة وهي الاندماج الكامل مع نوات
+
+105
+00:07:51,850 --> 00:07:55,270
+البويضة من أجل الحصول على ما يُرى باسم الزيجوت
+
+106
+00:07:55,270 --> 00:07:59,070
+فبالتالي فشلت عملية ال fertilization The sperm
+
+107
+00:07:59,070 --> 00:08:03,590
+cell of male with Globus ospermia however have a
+
+108
+00:08:03,590 --> 00:08:07,030
+round head and no acrosome عنده round head طبيعي
+
+109
+00:08:07,030 --> 00:08:11,090
+ولكن ال acrosome مش موجود المسؤول عنهإفراز
+
+110
+00:08:11,090 --> 00:08:14,090
+الإنزيمات المهمة لعملية ال penetration والمهمة
+
+111
+00:08:14,090 --> 00:08:18,010
+لعملية ال complete fusion the abnormal sperm are
+
+112
+00:08:18,010 --> 00:08:21,870
+unable to fertilize an egg and led to infertility
+
+113
+00:08:21,870 --> 00:08:25,390
+هذا بالوضع الطبيعي ولكن حكينا أن عملية ال
+
+114
+00:08:25,390 --> 00:08:29,140
+penetration تغلبت عليها بال eggsولكن في أمور تانية
+
+115
+00:08:29,140 --> 00:08:33,000
+الإجزي ما بقدر أو ما بستطيع أن يتغلب عليها وهي
+
+116
+00:08:33,000 --> 00:08:36,280
+الاندماج الكامل however, the successful
+
+117
+00:08:36,280 --> 00:08:39,200
+fertilization, pregnancy and overspring have
+
+118
+00:08:39,200 --> 00:08:44,120
+result after treat the oocyte post-egzi by either
+
+119
+00:08:44,120 --> 00:08:47,980
+chemical agent or electrical pulse what's the
+
+120
+00:08:47,980 --> 00:08:50,860
+meaning of this statement؟ بيقولك في الأولى
+
+121
+00:08:50,860 --> 00:08:55,220
+الأخيرة تم التخلص والتغلب علىعدم القدرة على
+
+122
+00:08:55,220 --> 00:08:59,860
+الاندماج بين النواتين من خلال حقن لـ spermatozoa
+
+123
+00:08:59,860 --> 00:09:03,880
+في منطقة بعيدة عن النواء الأنثوية الموجودة داخل
+
+124
+00:09:03,880 --> 00:09:08,320
+البويضة ثم معالجة هذه العملية بتعريض البويضة بعد
+
+125
+00:09:08,320 --> 00:09:14,160
+عملية الحقن إلى تيار كهربائي بفرق جهد معين ومنطقي
+
+126
+00:09:14,160 --> 00:09:18,000
+وقليل إلى حد ما أو إضافة بعض المواد الكيميائية
+
+127
+00:09:18,000 --> 00:09:23,070
+التي تسهل وتحفظ عملية ال fusionمما يؤدي إلى تكوين
+
+128
+00:09:23,070 --> 00:09:27,370
+الـ Zygote فبالتالي تغلبنا على مشكلة الاندماج
+
+129
+00:09:27,370 --> 00:09:30,970
+المرحلة التالتة أو ال level التالت من المستويات
+
+130
+00:09:30,970 --> 00:09:35,090
+التي يفشل فيها عملية الحقن المجهري تسمى failure to
+
+131
+00:09:35,090 --> 00:09:38,490
+cleavage after eggs fertilization تمام التمام ما
+
+132
+00:09:38,490 --> 00:09:42,110
+فيه عنده مشكلة فيه عنده نطف أنثوية و ذكيرية النطف
+
+133
+00:09:42,110 --> 00:09:44,650
+الذكيرية مافيش فيها مشكلة من حيث العدد و ال
+
+134
+00:09:44,650 --> 00:09:48,900
+morphology و ال functionalحصلت على immobilized
+
+135
+00:09:48,900 --> 00:09:53,760
+sperm of life عملتله insertion انحقا و اتغلبت على
+
+136
+00:09:53,760 --> 00:09:57,340
+مشكلة ال fusion باستعريضها إلى electrical field
+
+137
+00:09:57,340 --> 00:10:01,590
+بفرق جوده منخفض صار في عندي اندماجولكن البويضة
+
+138
+00:10:01,590 --> 00:10:05,490
+المندمجة الملقحة اللتي أصبحت مندمجة مع النواية
+
+139
+00:10:05,490 --> 00:10:09,930
+الذكرية لن تستطيع الاستمرار في الانقسام okay
+
+140
+00:10:09,930 --> 00:10:13,990
+انقسمت صارت عندى خليتين صارت عندى أربعة بعد كده
+
+141
+00:10:13,990 --> 00:10:19,830
+توقفت لم تكمل عملية الانقسام للوصول إلى ال 32 و64
+
+142
+00:10:19,830 --> 00:10:24,710
+خلية هذا بنسميها failure of cleavage يعني الخلل في
+
+143
+00:10:24,710 --> 00:10:28,610
+الانقسام او الفشل في الانقسام فبالتالي ما بستطيع
+
+144
+00:10:28,610 --> 00:10:34,090
+اقول عنها imperialوين رجعت لرحم السيدة بيكون فرصة
+
+145
+00:10:34,090 --> 00:10:38,270
+الفشل عالية جدا when the couple with filled with
+
+146
+00:10:38,270 --> 00:10:41,750
+filled eggs fertilization attempt future eggs
+
+147
+00:10:41,750 --> 00:10:44,990
+cycle their success rate were similar to other
+
+148
+00:10:44,990 --> 00:10:48,430
+couples undergoing repeating eggs cycle معنى
+
+149
+00:10:48,430 --> 00:10:52,080
+الكلام؟إن لو أنا عندي two couples عملوا إجزي cycle
+
+150
+00:10:52,080 --> 00:10:56,640
+وفشلت هيعملوا إجزي cycle جديدة مش معناها إن فشلت
+
+151
+00:10:56,640 --> 00:11:00,100
+هتنجح التانية ومش معناها إن نسبة الفشل هتكون
+
+152
+00:11:00,100 --> 00:11:04,660
+متتابعة يعني طالما فشلت الأولى لازم تفشل التانية و
+
+153
+00:11:04,660 --> 00:11:07,520
+التالتة و الرابعة طالما فشلت الأولى التانية لازم
+
+154
+00:11:07,520 --> 00:11:12,220
+تنجح لأ كل cycle لها chance بتسميه independent
+
+155
+00:11:12,220 --> 00:11:15,740
+event or independent chance لا تعتمد على الذي
+
+156
+00:11:15,740 --> 00:11:20,200
+يسبقها ولا تعتمد على الذي يليهافبالتالي ممكن تفشل
+
+157
+00:11:20,200 --> 00:11:24,960
+و ممكن تنجح the main problem that led to IGZ
+
+158
+00:11:24,960 --> 00:11:28,440
+failure أول حاجة spermatozoa remained attached to
+
+159
+00:11:28,440 --> 00:11:31,880
+the IGZ pipet while beginning release طبعا هنتكلم
+
+160
+00:11:31,880 --> 00:11:35,300
+عن الأسباب التي تؤدي إلى فشل IGZ ولكن من ناحية
+
+161
+00:11:35,300 --> 00:11:39,800
+practical من ناحية practical أول حاجة أنه أنا و
+
+162
+00:11:39,800 --> 00:11:43,120
+أنا بشغل ماقدرت أعمل releasing لل spermatozoa داخل
+
+163
+00:11:43,120 --> 00:11:48,130
+الvoider لسبب التصاقالـ spermatozoa في الصفح
+
+164
+00:11:48,130 --> 00:11:53,050
+الداخلي لل injection needle جد ما أضغط عشان أنزل و
+
+165
+00:11:53,050 --> 00:11:57,370
+أعمل releasing لل spermatozoa من ال injection
+
+166
+00:11:57,370 --> 00:12:02,090
+needle لأ مافي إمكانية لنصل إتصاب حاد و قوي ما بين
+
+167
+00:12:02,090 --> 00:12:04,270
+الجدار الداخلي لل injection needle و ال
+
+168
+00:12:04,270 --> 00:12:08,370
+spermatozoa insufficient immobilization of
+
+169
+00:12:08,370 --> 00:12:12,190
+spermatozoa as assessed by subsequent movement
+
+170
+00:12:12,190 --> 00:12:16,110
+بمعنى آخرإن ماعند الكمية الكافية من ال spermatozoa
+
+171
+00:12:16,110 --> 00:12:19,550
+اللي عملت لها immobilization كمية ال spermatozoa
+
+172
+00:12:19,550 --> 00:12:23,550
+أو عددها اللازمة الحقن لا يتماشى مع الكمية
+
+173
+00:12:23,550 --> 00:12:26,990
+المتوفرة يعني أنا عند خمس بويضات ماعملت
+
+174
+00:12:26,990 --> 00:12:30,130
+immobilization إلا لـ two spermatozoa لأن هم
+
+175
+00:12:30,130 --> 00:12:34,460
+المتوفرين فقطفبالتالي سيؤدي إلى فشل جزءي لعملية
+
+176
+00:12:34,460 --> 00:12:37,420
+الحقل المجهد Rejection of spermatozoa into
+
+177
+00:12:37,420 --> 00:12:42,320
+preventive space after exit إن الـ space بعد زولة
+
+178
+00:12:42,320 --> 00:12:46,150
+بلوسيدا الموجود في الـ oocyte عمل rejection لـالـ
+
+179
+00:12:46,150 --> 00:12:48,850
+spermatozoa فبالتالي فشلت شو يعني عمل rejection؟
+
+180
+00:12:48,850 --> 00:12:52,270
+يعني ماقدر يتقطبل دخول ال spermatozoa منع ال
+
+181
+00:12:52,270 --> 00:12:56,150
+spermatozoa انه يدخل طرد ال spermatozoa من الخلية
+
+182
+00:12:56,150 --> 00:12:59,790
+ككل هذه الحالات تتصير فلاجد حالات نادرة إلها
+
+183
+00:12:59,790 --> 00:13:04,670
+أسبابها المعينة difficult breaking of ulma أنا عند
+
+184
+00:13:04,670 --> 00:13:08,470
+injection needle هي اللي هتخترق الـ zoonablus ده
+
+185
+00:13:08,470 --> 00:13:12,050
+وتخترق و تدخل في ال cytoplasm صار في عند صعوبة
+
+186
+00:13:12,050 --> 00:13:15,630
+ماقدرت ال needleبتختارق لأن عملية الاختلاق لازم
+
+187
+00:13:15,630 --> 00:13:20,470
+تكون smooth و soft لإن لو زدت الضغط ممكن أعمل
+
+188
+00:13:20,470 --> 00:13:23,750
+rapture لل oocyte شو اللي بيخلي عندي مشكلة في
+
+189
+00:13:23,750 --> 00:13:26,190
+عملية اختراق الذنب اليوسيط أو القلمة أو ال
+
+190
+00:13:26,190 --> 00:13:30,770
+cytoplasmic of oocyte في وجود rigidity وجود صلابة
+
+191
+00:13:30,770 --> 00:13:36,080
+إلى حد ما فيمكونات الـ oocyte أو في مكونات الـ
+
+192
+00:13:36,080 --> 00:13:40,120
+zoonableucida فبالتالي ما بدي أغامل و أضغط
+
+193
+00:13:40,120 --> 00:13:45,810
+بالزيادة عشان ما أخسر البوايدة to overcomeهذا
+
+194
+00:13:45,810 --> 00:13:49,950
+الفرصة السعيدة للتنقل من أوسايت الـ Oocyte و الـ
+
+195
+00:13:49,950 --> 00:13:54,350
+alternative laser assist XE لقد تم تفضيلها مؤخراً
+
+196
+00:13:54,350 --> 00:13:59,090
+و تم تطبيقها بشركة patient بمشكلة مثل هذه المشكلة
+
+197
+00:13:59,090 --> 00:14:03,010
+ممكن أن اتغلب على ال rigidity ممكن أن اتغلب على
+
+198
+00:14:03,010 --> 00:14:06,910
+عدم استقبال ال space بعد زيورة الفلوسيدال ال
+
+199
+00:14:06,910 --> 00:14:10,850
+spermatozoa من خلال حاجة و تقنيك مهم جدا بتسموه
+
+200
+00:14:10,850 --> 00:14:14,460
+laser assist hatching أو laser hatchingإيش فكرة
+
+201
+00:14:14,460 --> 00:14:17,120
+الـ Laser Hatching؟ إنه عندي أنا مدفع إلى حد ما
+
+202
+00:14:17,120 --> 00:14:21,160
+بيسموه مدفع الـ Laser أو مطلق الـ Laser بطلق نبضات
+
+203
+00:14:21,160 --> 00:14:23,620
+من الـ Laser على منطقة معينة موجودة في الزورة
+
+204
+00:14:23,620 --> 00:14:29,240
+بليوسيدا علشان يعملها عملية ثقوف داخلها فبالتالي
+
+205
+00:14:29,240 --> 00:14:33,860
+بسمح بدخول ال injection needle بسهولة خصوصا إذا
+
+206
+00:14:33,860 --> 00:14:37,000
+كان في عندي نوع من أنواع الصلابة و الصعوبة في
+
+207
+00:14:37,000 --> 00:14:40,940
+اختراق الزورة بليوسيدا من خلال ال injection needle
+
+208
+00:14:40,940 --> 00:14:47,160
+زي ما أحنا شايفين هناهي الـ Oocyte الـ Oocyte أجى
+
+209
+00:14:47,160 --> 00:14:51,880
+مدفع الليزر، ضرط طلقة هنا، فعملت فجوة بمقدار 5 إلى
+
+210
+00:14:51,880 --> 00:14:57,760
+10 ميكروميتر في الزنا بليوسيدا هذه الفجوة تسمح للـ
+
+211
+00:14:57,760 --> 00:15:03,080
+injection needle بالدخول ببساطة وبسهولة للوصول إلى
+
+212
+00:15:03,080 --> 00:15:07,380
+أقرب منطقة من الـcytoplasmالفجوة اللي بتصير
+
+213
+00:15:07,380 --> 00:15:10,320
+مابتكون كاملة عشان مايصيرش leakage لمحتوى
+
+214
+00:15:10,320 --> 00:15:13,400
+الـcytoplasm لأن هذا النقطة البسيطة اللتي أصبحت
+
+215
+00:15:13,400 --> 00:15:17,660
+تمنع ال leakage يجب اختراقها باستخدام ال injection
+
+216
+00:15:17,660 --> 00:15:21,280
+needed إيش هذا اسم التكنيك؟ اسمه Laser Hatching
+
+217
+00:15:21,280 --> 00:15:27,320
+وحنتكلم عنه بشكل موسع في عملية ال embryo biopsy في
+
+218
+00:15:27,320 --> 00:15:30,520
+ال chapter اللي قادم ان شاء الله خليني أشوف
+
+219
+00:15:30,520 --> 00:15:34,640
+الفيديو هذاكيف و بيتكلم و بحكي عن عملية الـ Laser
+
+220
+00:15:34,640 --> 00:15:41,420
+Hatch So
+
+221
+00:15:41,420 --> 00:15:43,560
+this is Deborah preparing one of our ICSI dishes
+
+222
+00:15:43,560 --> 00:15:46,620
+which actually are once again prepared sterile
+
+223
+00:15:46,620 --> 00:15:52,280
+with certified and tested medias what she's doing
+
+224
+00:15:52,280 --> 00:15:57,780
+initially here is getting out the PVP or the first
+
+225
+00:15:57,780 --> 00:16:01,970
+media that we need in order to have the spermلذلك
+
+226
+00:16:01,970 --> 00:16:05,290
+يبطئهم قليلاً لكي نستطيع أن نجربهم في البداية
+
+227
+00:16:05,290 --> 00:16:10,170
+تستخدم ميديا ميكرو درس ميكرو درس ميكرو درس ميكرو
+
+228
+00:16:10,170 --> 00:16:10,310
+درس ميكرو درس ميكرو درس ميكرو درس ميكرو درس ميكرو
+
+229
+00:16:10,310 --> 00:16:12,370
+درس ميكرو درس ميكرو درس ميكرو درس ميكرو درس ميكرو
+
+230
+00:16:12,370 --> 00:16:12,550
+درس ميكرو درس ميكرو درس ميكرو درس ميكرو درس ميكرو
+
+231
+00:16:12,550 --> 00:16:12,650
+درس ميكرو درس ميكرو درس ميكرو درس ميكرو درس ميكرو
+
+232
+00:16:12,650 --> 00:16:26,850
+درس ميكرو درس ميكرو
+
+233
+00:16:26,850 --> 00:16:33,740
+درس ميكرو درFinding the media that we need in
+
+234
+00:16:33,740 --> 00:16:36,380
+order to do this, this micro manipulation media,
+
+235
+00:16:36,500 --> 00:16:38,720
+she's going to make multiple drops here, so we'd
+
+236
+00:16:38,720 --> 00:16:43,070
+be able to do more than one egg at a timeطبعا هنا
+
+237
+00:16:43,070 --> 00:16:46,210
+هي بتعمل preparation for exe dish وضعت القطرة
+
+238
+00:16:46,210 --> 00:16:50,250
+الأولى وهي ال PVP media المسئولة عن تحميل الجميطات
+
+239
+00:16:50,250 --> 00:16:54,210
+الذكرية فيها ثم وضعت ال media الخاصة بال oocyte
+
+240
+00:16:54,210 --> 00:16:57,530
+بشرط يقولنا 8 قطرات في كل قطرة بوايدة أو بوايدتين
+
+241
+00:16:57,530 --> 00:17:01,230
+للناس المبتدئة although it's only one patient at a
+
+242
+00:17:01,230 --> 00:17:07,060
+time and we never reuse a dishالعزيزة قمت بإنهاء
+
+243
+00:17:07,060 --> 00:17:10,200
+الأسلحة الأولى والعزيزة ستقوم بتغطية الزبدة التي
+
+244
+00:17:10,200 --> 00:17:15,520
+ستكون محمية حماية لكي لا تتفرد و لكي تبقى مرموزا
+
+245
+00:17:15,520 --> 00:17:21,620
+مرموزا مرموزا مرموزا مرموزا مرموزا
+
+246
+00:17:21,620 --> 00:17:22,500
+مرموزا
+
+247
+00:17:47,840 --> 00:17:51,040
+طبعا هنا هيبدأ عملية الـ injection بالتعرف على
+
+248
+00:17:51,040 --> 00:17:53,840
+الميكروسكوب بالإضافة إلى التحدث عن الـ injection
+
+249
+00:17:53,840 --> 00:17:58,980
+needle و الـholder tubeهيبدأ بتركيب الـ holder
+
+250
+00:17:58,980 --> 00:18:02,500
+tube ثم تركيب ال injection needle وعمليات ال إكسي
+
+251
+00:18:02,500 --> 00:18:05,620
+put it on a micro tool holder and on the left hand
+
+252
+00:18:05,620 --> 00:18:09,600
+side here we will put it up and in place there you
+
+253
+00:18:09,600 --> 00:18:12,820
+see a nice clean holding pipette about 120 microns
+
+254
+00:18:12,820 --> 00:18:16,140
+in size about what will be the same size of the
+
+255
+00:18:16,140 --> 00:18:18,660
+eggs that we'll be using now over on this side I
+
+256
+00:18:18,660 --> 00:18:20,780
+have to put the iksi needle now this needle is
+
+257
+00:18:20,780 --> 00:18:25,780
+very very small it's aboutEight microns in size.
+
+258
+00:18:26,200 --> 00:18:30,020
+You can fit at the end of this one hundred of
+
+259
+00:18:30,020 --> 00:18:33,040
+these in the thickness of one hair. So once again
+
+260
+00:18:33,040 --> 00:18:35,060
+I get everything prepared, get it up and into
+
+261
+00:18:35,060 --> 00:18:37,680
+place, and then go through the process of
+
+262
+00:18:37,680 --> 00:18:41,060
+alignment to get everything set ahead of time.So
+
+263
+00:18:41,060 --> 00:18:43,800
+we're getting prepared to do an ICSI here. So we
+
+264
+00:18:43,800 --> 00:18:45,660
+need to label up the dish once again with a
+
+265
+00:18:45,660 --> 00:18:47,940
+diamond pen with the name of the patient who we're
+
+266
+00:18:47,940 --> 00:18:51,060
+going to do so that we know what it is.Then we
+
+267
+00:18:51,060 --> 00:18:53,940
+have a second person come and check that the sperm
+
+268
+00:18:53,940 --> 00:18:56,600
+matches up to the paperwork for this specific
+
+269
+00:18:56,600 --> 00:18:59,380
+patient and I have to verify and then additionally
+
+270
+00:18:59,380 --> 00:19:03,780
+that the individual eggs match up with the patient
+
+271
+00:19:03,780 --> 00:19:07,010
+specific information.فانتظرين 2 شخص واحد دائما قبل
+
+272
+00:19:07,010 --> 00:19:08,990
+أن يكون اي شيء مفهوم و نقوم بمزيد من البيضاء و
+
+273
+00:19:08,990 --> 00:19:12,870
+النار ففي هذه الحالة انا واضح انها شهدت كل ما
+
+274
+00:19:12,870 --> 00:19:14,970
+احتاجه لذلك انا قمت بتعامل عبارة عن عبارة عن عبارة
+
+275
+00:19:14,970 --> 00:19:18,750
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+276
+00:19:18,750 --> 00:19:18,930
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+277
+00:19:18,930 --> 00:19:19,510
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+278
+00:19:19,510 --> 00:19:19,710
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+279
+00:19:19,710 --> 00:19:33,470
+عن عبارة عن عبارة عن عبارة عن عبار
+
+280
+00:19:34,800 --> 00:19:37,520
+Now I will go ahead and grab the eggs that I need
+
+281
+00:19:37,520 --> 00:19:44,360
+and I'll move them to the EGGSY DISH طبعا هنا بدأ
+
+282
+00:19:44,360 --> 00:19:48,520
+بتحميل ال spermatozoa as a male gamete على قطرة ال
+
+283
+00:19:48,520 --> 00:19:52,300
+PVV بعدين هياخد ال oocyte من الطبق الخاص فيه
+
+284
+00:19:52,300 --> 00:19:55,940
+وينقلهم على الطبق الخاص بال EGGSY DISH تمهيدا
+
+285
+00:19:55,940 --> 00:19:56,780
+لعملية الحقنة
+
+286
+00:20:06,560 --> 00:20:08,980
+So I'll put them away temporarily in the micro
+
+287
+00:20:08,980 --> 00:20:11,280
+chamber which is getting humidity and gas levels
+
+288
+00:20:11,280 --> 00:20:14,040
+at the appropriate thing Now my eggs and sperm are
+
+289
+00:20:14,040 --> 00:20:16,100
+both in the same dish and we're going to go and
+
+290
+00:20:16,100 --> 00:20:20,080
+actually perform the ICSI procedureلذلك إذا كنت
+
+291
+00:20:20,080 --> 00:20:22,960
+تنظر كما أفعل هذا على الشاشة الآن ترى مجموعة من
+
+292
+00:20:22,960 --> 00:20:26,480
+الأشياء الصغيرة المتحركة هؤلاء هم الصحراء سأقوم
+
+293
+00:20:26,480 --> 00:20:32,560
+بإزالة واحدة منهم في جزء من إكسي نيدلي طبعا هنا في
+
+294
+00:20:32,560 --> 00:20:35,580
+البداية هيدخل على ال media PVP عشان يبدأ يعمل
+
+295
+00:20:35,580 --> 00:20:39,460
+immobilization للصحراء الذواء وينقل عدد منهم إلى
+
+296
+00:20:39,460 --> 00:20:43,400
+الداخل ال injection needle من أجل تمهيدة عملية ال
+
+297
+00:20:43,400 --> 00:20:47,580
+injection in order to then inject them into the
+
+298
+00:20:47,580 --> 00:20:48,520
+mature eggs
+
+299
+00:20:51,700 --> 00:20:53,720
+So initially I'm bringing down my Yixin needle
+
+300
+00:20:53,720 --> 00:20:57,840
+which you can see now on the screen and I'm going
+
+301
+00:20:57,840 --> 00:21:01,100
+to go in and find a few very normal looking sperm
+
+302
+00:21:01,100 --> 00:21:04,340
+and
+
+303
+00:21:04,340 --> 00:21:09,840
+I'm going to immobilize them by
+
+304
+00:21:09,840 --> 00:21:13,780
+very carefully but strongly rubbing them against
+
+305
+00:21:13,780 --> 00:21:18,760
+the bottom of the dish in order toلتحركهم و
+
+306
+00:21:18,760 --> 00:21:23,200
+لتحركهم في التفكير بأنهم يدخلوا في البيض نفسه.
+
+307
+00:21:23,800 --> 00:21:27,840
+لذلك انا اقوم بتحريك واحد و اخرجه من البيبت و اقوم
+
+308
+00:21:27,840 --> 00:21:30,220
+بتحريكه من خلفه. لذلك الان انا اقوم بتحريك واحد
+
+309
+00:21:30,220 --> 00:21:34,320
+واحد من داخلي اللوح. إذا كنت تنظر جيدا سوف اريك ان
+
+310
+00:21:34,320 --> 00:21:38,040
+في نهاية اللوح من اللوح. انا اقوم بتحريك شخصية رأس
+
+311
+00:21:38,040 --> 00:21:43,600
+كبيرة في نهاية اللوح. لذلك في نهاية اللوح من
+
+312
+00:21:43,600 --> 00:21:45,260
+البيبت. انا اقوم بتحريك شخصية رأس كبيرة.
+
+313
+00:21:48,480 --> 00:21:54,620
+أدى عملية الحقن طبعا
+
+314
+00:21:54,620 --> 00:21:58,180
+هنا بيبدأ عملية الحقن اعمل عملية fix لل oocyte
+
+315
+00:21:58,180 --> 00:22:01,660
+باستخدام ال holder tube بشرط ان يكون ال body عند
+
+316
+00:22:01,660 --> 00:22:05,220
+الساعة 6 او عند الساعة 12 ويبدأ عملية ال injection
+
+317
+00:22:05,220 --> 00:22:09,480
+عند الساعة 3 بالظبط تخيل ان ال injection نيدل بكل
+
+318
+00:22:09,480 --> 00:22:13,470
+بساطة و بكل هدوء وبشكل smooth جداbrought the sperm
+
+319
+00:22:13,470 --> 00:22:16,230
+head right to the end of the needle and now I'm
+
+320
+00:22:16,230 --> 00:22:19,870
+pushing my way through the shell of the egg and
+
+321
+00:22:19,870 --> 00:22:22,410
+there it went and now I'm pushing my way through
+
+322
+00:22:22,410 --> 00:22:25,930
+the membrane of the egg and it broke now I'm going
+
+323
+00:22:25,930 --> 00:22:28,090
+to mix the sperm and the inside of the egg
+
+324
+00:22:28,090 --> 00:22:32,330
+together and I'm going to leave the eggI just
+
+325
+00:22:32,330 --> 00:22:35,250
+performed one single ICSI and deposited one single
+
+326
+00:22:35,250 --> 00:22:38,270
+sperm at the end.So to give you an idea you can
+
+327
+00:22:38,270 --> 00:22:40,490
+see the channel that I went in is directly along
+
+328
+00:22:40,490 --> 00:22:43,690
+here and at the very very end is the single sperm
+
+329
+00:22:43,690 --> 00:22:46,350
+head that was deposited there.So we've done one
+
+330
+00:22:46,350 --> 00:22:49,970
+roll that one away and let's bring up the next
+
+331
+00:22:49,970 --> 00:22:53,690
+candidate.I will align that much that polar body
+
+332
+00:22:53,690 --> 00:22:57,750
+for knowing where it's mature and now I will move
+
+333
+00:22:57,750 --> 00:23:02,470
+throughكدا تمت عملية حقن one o o site باستخدام
+
+334
+00:23:02,470 --> 00:23:07,350
+single sperm قرفنا على ال exe procedure من لحظة
+
+335
+00:23:07,350 --> 00:23:11,290
+تحضير ال exe dish حتى عملية الحقن بعد ما تم عملية
+
+336
+00:23:11,290 --> 00:23:15,610
+الحقن بتم عملية نقلهم إلى ال incubator في ظروف
+
+337
+00:23:15,610 --> 00:23:19,820
+معينة من أجل عمليةالـ Cleavage وهذا اللي هنتكلم
+
+338
+00:23:19,820 --> 00:23:23,460
+عليها فيما بعد Embryo evaluation from the zygote
+
+339
+00:23:23,460 --> 00:23:27,180
+to the blastocyst stage كيف يتم انقسام ال embryo
+
+340
+00:23:27,180 --> 00:23:31,280
+أو البويضة المخصبة للوصول إلى مرحلة ال zygote ثم
+
+341
+00:23:31,280 --> 00:23:34,200
+للوصول إلى مرحلة ال blastocyte أو ال blastocyst
+
+342
+00:23:34,200 --> 00:23:36,700
+بيسموها في بعض الأحيان أو في معظم الأحيان بيسموها
+
+343
+00:23:36,700 --> 00:23:42,460
+blastocyst لكي نحصل على embryo كامل ال
+
+344
+00:23:42,460 --> 00:23:45,780
+introduction ببساطة جدا بعد ال oocyte injection
+
+345
+00:23:46,140 --> 00:23:49,640
+There are moved to the culture dish prepared and
+
+346
+00:23:49,640 --> 00:23:56,370
+pre-incubated for more than 24 hours بمعنى آخرإن
+
+347
+00:23:56,370 --> 00:24:02,190
+البويضات اللي صارلها عملية
+
+348
+00:24:02,190 --> 00:24:05,390
+denodation
+
+349
+00:24:05,390 --> 00:24:09,910
+وهي إزالة الكيومال السل من عليها يجب أن تنقل إلى
+
+350
+00:24:09,910 --> 00:24:12,990
+طبق ال petri dish أو ال Exodus اللي شفناه قبل
+
+351
+00:24:12,990 --> 00:24:17,910
+بشوية و اللي لازم يكون محضر قبل من 6 إلى 12 ساعة
+
+352
+00:24:17,910 --> 00:24:23,170
+من عملية الحقن علشان ياخد ال atmosphericأو ياخد ال
+
+353
+00:24:23,170 --> 00:24:27,170
+fact أو ياخد المنظومة
+
+354
+00:24:27,170 --> 00:24:30,830
+المطلوبة اللي لازم تكون في ال incubator و يصير
+
+355
+00:24:30,830 --> 00:24:38,110
+عملية تكيف للطبقبعد كده باستخدام إبندروف إتيوب
+
+356
+00:24:38,110 --> 00:24:44,030
+بنعمل على نقل الـ oocyte اللي صارها عملية تعرية أو
+
+357
+00:24:44,030 --> 00:24:48,590
+عملية إزالة ال accumulus إلى ال drop media اللي
+
+358
+00:24:48,590 --> 00:24:53,590
+موجودة على الأطراف و اللي عددها تمانية و بناخد حجم
+
+359
+00:24:53,590 --> 00:24:56,930
+معين من ال spermatozoa و بنحطها في القطرة الموجودة
+
+360
+00:24:56,930 --> 00:25:01,750
+في المتصف اللي سمناها PVP media من أجل عملية ال M
+
+361
+00:25:01,750 --> 00:25:06,300
+-mobilization طبعا ال Exodusلازم يوضع فيه CO2
+
+362
+00:25:06,300 --> 00:25:11,980
+انكبياتور بيحتوي على 37 درجة مئوية 5% carbon
+
+363
+00:25:11,980 --> 00:25:17,180
+dioxide و 95% humidity ال fertilization check بعد
+
+364
+00:25:17,180 --> 00:25:20,460
+الإجزي لازم أعمل fertilization check لل OO site
+
+365
+00:25:20,460 --> 00:25:25,800
+بعد 16 إلى 18 ساعة من عملية ال insemination أو
+
+366
+00:25:25,800 --> 00:25:28,830
+عملية ال intracytoplasmic sperm injectionيعني
+
+367
+00:25:28,830 --> 00:25:31,950
+بمعنى أخر لو أنا عملت injection للبوايدة الساعة
+
+368
+00:25:31,950 --> 00:25:35,510
+ستة صباحا تاني يوم الساعة ستة صباحا لازم أبدأ أعمل
+
+369
+00:25:35,510 --> 00:25:39,590
+check-up تحت الميكروسكوب هل صار cleavage للبوايدة
+
+370
+00:25:39,590 --> 00:25:44,210
+المخصبة ولا لأ هذه مهم جدا أول مرحلة من مراحل
+
+371
+00:25:44,210 --> 00:25:48,510
+النجاح الإجزي وجود ما يُعرف باسم Lebron nuclei
+
+372
+00:25:48,510 --> 00:25:51,970
+Lebron nuclei هنتكلم عنها وشوهي Lebron nuclei
+
+373
+00:25:51,970 --> 00:25:58,450
+وشوهو إزاي God كيف يتم تحديدوعمل evaluation و
+
+374
+00:25:58,450 --> 00:26:01,330
+assessment لعملية ال fertilization واللي أنا من
+
+375
+00:26:01,330 --> 00:26:04,470
+خلالها بقول والله عملية ال fertilization نجحت أو
+
+376
+00:26:04,470 --> 00:26:07,310
+عملية ال fertilization فشلة morphological
+
+377
+00:26:07,310 --> 00:26:12,550
+assessment is evaluated on several days Thursday
+
+378
+00:26:12,550 --> 00:26:17,550
+0, 1, 2, 3 شو يعني Thursday 0؟ Thursday 0 يعني
+
+379
+00:26:17,550 --> 00:26:21,740
+اليوم اللي صار فيه عملية ال injection من خلالتقييم
+
+380
+00:26:21,740 --> 00:26:25,280
+البويضة، هل البويضة ناضجة أو غير ناضجة، من خلال
+
+381
+00:26:25,280 --> 00:26:28,160
+تقييم الـSpermatozoa، هل الـSpermatozoa صالحة
+
+382
+00:26:28,160 --> 00:26:31,380
+لعملية الحقن ولا لا، هذه بنسميها Fairest
+
+383
+00:26:31,380 --> 00:26:36,640
+Evaluation in the Zero Day أسيسمات في الـDay 5 و
+
+384
+00:26:36,640 --> 00:26:40,620
+Day 6 مرتبطة بـExtent Culture to the Plastocyst
+
+385
+00:26:40,620 --> 00:26:44,270
+Stageيعني أنا ممكن أعمل evaluation في اليوم رقم 0
+
+386
+00:26:44,270 --> 00:26:49,890
+و 1 و 2 و 3 و 4 و 5 و 6 اليوم رقم 0 أنا بتأكد منه
+
+387
+00:26:49,890 --> 00:26:53,970
+من الجامدات صالحة أم غير صالحة لعملية الحقناليوم
+
+388
+00:26:53,970 --> 00:26:58,690
+الـ 1 و 2 و 3 و 4 بتأكد من عملية الإنقسامات سليمة
+
+389
+00:26:58,690 --> 00:27:03,250
+ولا لأ خمسة و ستة بستخدمهم في بعض الأحيان إذا كان
+
+390
+00:27:03,250 --> 00:27:07,310
+في عند عملية زيادة في فترة ال incubation كان عملية
+
+391
+00:27:07,310 --> 00:27:10,830
+الإنقسام عملية غير متناسقة فبالتالي بدي أزيد فترة
+
+392
+00:27:10,830 --> 00:27:14,450
+ال incubation في ال incubator و أرجع بعد اليوم
+
+393
+00:27:14,450 --> 00:27:19,920
+الخامس علشان أضمن أنه العددالبلاستوست أو الجنين
+
+394
+00:27:19,920 --> 00:27:24,460
+وصل إلى level معين من المقسمات تسمح ليه بعمل عملية
+
+395
+00:27:24,460 --> 00:27:30,080
+إعادة لهذا الجنين طبعا في ال D0 evaluation تعتمد
+
+396
+00:27:30,080 --> 00:27:33,380
+على تقييم ال oocyte من حيث ال morphology هل ال
+
+397
+00:27:33,380 --> 00:27:36,460
+oocyte صالح العملية الحقن ولا لأ تقييم ال
+
+398
+00:27:36,460 --> 00:27:39,950
+spermatozoa من حيث العددمن حيث الـ morphology، من
+
+399
+00:27:39,950 --> 00:27:43,990
+حيث الـ functional وهذه العملية بتصير جامع العملية
+
+400
+00:27:43,990 --> 00:27:47,650
+الـ insemination prior to insemination أو إجزي
+
+401
+00:27:47,650 --> 00:27:51,750
+وبما فيهم العملية بيسميها oocyte denodation عملية
+
+402
+00:27:51,750 --> 00:27:55,530
+تعريط الـ oocyte طبعا ال immature oocyte لا تصلح
+
+403
+00:27:55,530 --> 00:27:59,630
+لعملية الحقن المجهري واللي سميناها إنها بتكون في
+
+404
+00:27:59,630 --> 00:28:05,570
+الـ GVأما الخلية والبوايدة التي تصلح لعملية الحقن
+
+405
+00:28:05,570 --> 00:28:08,930
+المجهري هي الخلية التي توقفت في القسم الميوزي
+
+406
+00:28:08,930 --> 00:28:12,190
+الثاني في مرحلة الـmetaphyse second metaphyse
+
+407
+00:28:12,190 --> 00:28:16,510
+واللي بتتميز بوجود fairest polar body، fairest
+
+408
+00:28:16,510 --> 00:28:19,810
+polar body، هذه بتكون صالحة لعملية ال
+
+409
+00:28:19,810 --> 00:28:23,110
+fertilizationخلصنا عملية ال evaluation للـ zero
+
+410
+00:28:23,110 --> 00:28:26,590
+day بنيجي لل evaluation لل first day ال first day
+
+411
+00:28:26,590 --> 00:28:30,090
+هي عبارة عن normal زيجوت formed on day one and
+
+412
+00:28:30,090 --> 00:28:33,150
+should have two pronuclear شو يعني الزيجوت؟
+
+413
+00:28:33,150 --> 00:28:35,530
+الواجهة أنا عندى فيه نواة ذكرية تأتي من ال sperm
+
+414
+00:28:35,530 --> 00:28:39,580
+متزوها و نواة أنثوية موجودة في البويضةعند الحقن
+
+415
+00:28:39,580 --> 00:28:43,220
+تندمج النواة الذكرية مع النواة الأنثوية فبيعطيني
+
+416
+00:28:43,220 --> 00:28:46,980
+نواة واحدة ولكن في بينهم انفصال بسيط جدا نسميه
+
+417
+00:28:46,980 --> 00:28:53,440
+pronuclei ال pronuclei يعني قبل النوية وسميتها 2PN
+
+418
+00:28:53,440 --> 00:28:57,300
+يعني 2 pronuclei لإن فيها نواة من ذكر و نواة من
+
+419
+00:28:57,300 --> 00:29:02,440
+أنثى عشان كده سمناهم 2PN و ال 2PN هي أول علامة من
+
+420
+00:29:02,440 --> 00:29:06,920
+علامات نجاح عملية الحقد المجهريلازم يقولوا اتنين
+
+421
+00:29:06,920 --> 00:29:10,920
+PN وهي ال two pronuclear هي عبارة عن equal في ال
+
+422
+00:29:10,920 --> 00:29:14,140
+size very close متقاربين من بعض ومن بعض وموجود في
+
+423
+00:29:14,140 --> 00:29:17,860
+ال center of cytoplasm مش على طرف البوايدة لأ في
+
+424
+00:29:17,860 --> 00:29:21,540
+منتصف البوايدة إذا المتمثلين في الحجم مقتربين من
+
+425
+00:29:21,540 --> 00:29:25,300
+بعض ومن بعض وفي منتصف الcytoplasm الخاص بالبوايدة
+
+426
+00:29:25,300 --> 00:29:28,680
+ال PN واللي سميتها pronuclear morphological should
+
+427
+00:29:28,680 --> 00:29:33,100
+be grade between60 to 80 hours post insemination
+
+428
+00:29:33,100 --> 00:29:37,680
+يعني متى بتظهر؟ بتظهر بعد 16 ساعة من عملية الإجزة
+
+429
+00:29:37,680 --> 00:29:40,780
+فإذا ظهرت بعد 16 ساعة من عملية الإجزة بقدر أقول
+
+430
+00:29:40,780 --> 00:29:45,260
+والله أن عملية الحق العملية سليمة وناجحة 100% ال M
+
+431
+00:29:45,260 --> 00:29:49,760
+phase is observed between 22 to 31 hour and a
+
+432
+00:29:49,760 --> 00:29:54,200
+cleavage to two cells stage taking place 25 to 33
+
+433
+00:29:54,200 --> 00:29:57,890
+hours post inseminationيعني بمعنى آخر أن البوايضة
+
+434
+00:29:57,890 --> 00:30:02,190
+الناضجة بعد عملية الإنقسام تأخذ لها لكي تنتقسم إلى
+
+435
+00:30:02,190 --> 00:30:05,630
+خليتين خدوا بالك فيه فرق بين ال two cells و ال two
+
+436
+00:30:05,630 --> 00:30:09,910
+PN ال two PN هي علاقة بالأنوية أما ال two cells
+
+437
+00:30:09,910 --> 00:30:16,470
+تأخذ لها من 25 ساعة إلى 4-33 ساعة بعد عملية الحقن
+
+438
+00:30:16,470 --> 00:30:22,170
+يعني تقريبا تقدر تقولبعد سبع ساعات من ظهور الـ
+
+439
+00:30:22,170 --> 00:30:26,330
+pronuclear تبدأ الخلية بالانقسام إلى خليتين لأن
+
+440
+00:30:26,330 --> 00:30:30,090
+بعد عملية ال insemination ب16 إلى 18 ساعة لازم
+
+441
+00:30:30,090 --> 00:30:35,750
+تكون ظهرت ال BN أو الـ 2BN 2 pronuclear بعد عملية
+
+442
+00:30:35,750 --> 00:30:41,910
+الحقن ب 225 ساعة تبدأ في ظهور عملية ال cleavage
+
+443
+00:30:41,910 --> 00:30:47,190
+للخلية لكي تصبح خليتين لكي تصبح خليتين طبعا ال BN
+
+444
+00:30:47,190 --> 00:30:50,540
+morphology is a very important stepwhen evaluating
+
+445
+00:30:50,540 --> 00:30:52,980
+morphology because it is the first point and the
+
+446
+00:30:52,980 --> 00:30:56,780
+first critical point to true and good grade of
+
+447
+00:30:56,780 --> 00:31:01,200
+embryo as I got embryo evaluation كيف انا بقدر
+
+448
+00:31:01,200 --> 00:31:04,080
+اقول والله هذه البوايضة نجحت في عملية الاخصاد
+
+449
+00:31:04,080 --> 00:31:10,500
+ونجحت في السير اتجاه الانقسام اول حاجة ظهور ال 2pm
+
+450
+00:31:10,500 --> 00:31:15,700
+بعد 16 ساعةتاني حاجة، ظهور الـ second polar body،
+
+451
+00:31:15,700 --> 00:31:19,280
+يعني صار في عندي 2PM بعد 16 أو 18 ساعة من عملية ال
+
+452
+00:31:19,280 --> 00:31:23,660
+injection تانياً، ظهر ال second polar body خارج
+
+453
+00:31:23,660 --> 00:31:26,900
+البوايدة، معناه صار اختزال لعدد الكرموزوات
+
+454
+00:31:26,900 --> 00:31:31,250
+الأنثويةإلى 23 كرموزوم لكي تندمج مع الـ 23 كرموزوم
+
+455
+00:31:31,250 --> 00:31:35,730
+اللي جاء من الأب فبصفح أندي 46 كرموزوم أو 23 زوج
+
+456
+00:31:35,730 --> 00:31:39,690
+من الكرموزوم الواحدة إذن the first critical point
+
+457
+00:31:39,690 --> 00:31:43,210
+ظهور الـ 2PN and the second critical point ظهور
+
+458
+00:31:43,210 --> 00:31:49,050
+الـ second polar body أي تأخر في ظهور الـ PN معناه
+
+459
+00:31:49,050 --> 00:31:53,170
+أنه بعد ال insemination أي تأخر بيكون مرتبط بعملية
+
+460
+00:31:53,170 --> 00:31:56,830
+تدهور في عملية development للإمبريوبيعطيني poor
+
+461
+00:31:56,830 --> 00:32:00,830
+embryo development بالإضافة إلى زيادة فرصة حدوث لـ
+
+462
+00:32:00,830 --> 00:32:04,150
+chromosomal abnormality و هذه مشكلة إنه والله
+
+463
+00:32:04,150 --> 00:32:08,070
+البيئة أنما زهرت بعد 18 ساعة زهرت بعد 25 ساعة
+
+464
+00:32:08,070 --> 00:32:11,890
+معناه في عندي مشكلة في ال chromosome تؤدي إلى
+
+465
+00:32:11,890 --> 00:32:15,690
+زيادة معدل حدوث لـ chromosomal abnormality هذه
+
+466
+00:32:15,690 --> 00:32:20,150
+نقطة والنقطة التانية قلنا اللي هي علاقة بال second
+
+467
+00:32:20,150 --> 00:32:23,510
+polar body طب في نقطة تالتة من خلالها بقدر أتحكم
+
+468
+00:32:23,510 --> 00:32:28,860
+وأحكمفي عملية نجاح عملية الإخصاب وهي عبارة عن ال
+
+469
+00:32:28,860 --> 00:32:31,920
+orientation شو يعني ال orientation؟ مقصود بال
+
+470
+00:32:31,920 --> 00:32:36,740
+orientation هي الالتفاف هل ال polar body و ال 2PN
+
+471
+00:32:36,740 --> 00:32:41,620
+في مسار واحد؟ هل في فضاء واحد ولا لأ؟ طيب ال polar
+
+472
+00:32:41,620 --> 00:32:46,460
+أو حاجة بنسميها ال pronuclear orientation is in
+
+473
+00:32:46,460 --> 00:32:49,620
+relationship to the polar body can also be used to
+
+474
+00:32:49,620 --> 00:32:53,490
+evaluate embryo morphology in day oneأول حاجة الـ
+
+475
+00:32:53,490 --> 00:32:58,160
+2 polar body ظهوره ثانية حاجة ظهور الـ 2PLتالت
+
+476
+00:32:58,160 --> 00:33:01,300
+حاجة ال orientation الموجودة ما بين ال pro nuclear
+
+477
+00:33:01,300 --> 00:33:08,140
+و ال polar body هل هم متوازين ولا لا علشان احنا
+
+478
+00:33:08,140 --> 00:33:11,740
+نحكي في الموضوع ده خلونا نشوف الصورة بتكون أفضل لو
+
+479
+00:33:11,740 --> 00:33:15,360
+احنا طلعنا على الصورة الموجودة في الأسفل بهذا
+
+480
+00:33:15,360 --> 00:33:20,120
+الشكل الصورة الموجودة في الأسفل تتحدث عن ال polar
+
+481
+00:33:20,120 --> 00:33:24,660
+و حاجة سمناها ال nuclear او ال pro nuclear
+
+482
+00:33:24,660 --> 00:33:29,200
+orientationهي أنا عندي نواة ذكرية وهي أنا عندي
+
+483
+00:33:29,200 --> 00:33:33,220
+نواة أنثوية موجودين مع بعضهم البعض في المنتصف
+
+484
+00:33:33,220 --> 00:33:38,020
+متماثلين في الحجم ملتسقين مع بعضهم البعض إذا عملية
+
+485
+00:33:38,020 --> 00:33:41,240
+ال fertilization ناجح إلى حد ما هي عند ال first
+
+486
+00:33:41,240 --> 00:33:44,280
+polar body وهي عند ال second polar body زهروا هي
+
+487
+00:33:44,280 --> 00:33:47,440
+عندي نقطة تانية تدل عن نجاح عملية ال fertilization
+
+488
+00:33:47,440 --> 00:33:51,120
+في نقطة تالتة؟ أه في نقطة تالتةإن الـ Orientation
+
+489
+00:33:51,120 --> 00:33:54,360
+الخاص بالـ Prone Nuclear تتماشى مع الـ Orientation
+
+490
+00:33:54,360 --> 00:33:57,060
+الخاصة بالـ Polar Body شو يعني؟ يعني الـ Polar
+
+491
+00:33:57,060 --> 00:34:01,980
+Body توازى لـ Prone Nuclear معناه إن عملية ال
+
+492
+00:34:01,980 --> 00:34:06,360
+fertilization عملية ناجحة بشكل كامل جدا، هذا معناه
+
+493
+00:34:06,360 --> 00:34:11,360
+الـ Parallel أو التوازىالصورة التانية هي خلّينا
+
+494
+00:34:11,360 --> 00:34:15,860
+نضع خط بهذا الشكل و نضع خط بهذا الشكل مافي عندى
+
+495
+00:34:15,860 --> 00:34:20,700
+عملية توازي ما بين الـ polar body location و ال
+
+496
+00:34:20,700 --> 00:34:25,040
+pronuclear location فهم not parallelفبالتالي مش
+
+497
+00:34:25,040 --> 00:34:28,500
+متوازين فبالتالي ال orientation غير صحيح يعني
+
+498
+00:34:28,500 --> 00:34:32,800
+عملية ال fertilization فاشلة بنسبة كبيرة جدا وقد
+
+499
+00:34:32,800 --> 00:34:36,540
+تؤدي إلى chromosome ال abnormality أو تأخر في
+
+500
+00:34:36,540 --> 00:34:41,200
+انقسام الجنين إذن فهمنا إيش المقصود بال pronuclear
+
+501
+00:34:41,200 --> 00:34:45,020
+orientation طب عملية التقييم في اليوم التاني و
+
+502
+00:34:45,020 --> 00:34:48,830
+اليوم التالت هل إلهامعايير معينة أكيد إلها معايير
+
+503
+00:34:48,830 --> 00:34:52,290
+معينة في اليوم التاني من عملية الـ insemination
+
+504
+00:34:52,290 --> 00:34:58,050
+أهم معيار ظهور ال 4-plastomere ومقصود فيها إن أنا
+
+505
+00:34:58,050 --> 00:35:02,010
+عندي خلية كبيرة هي الـboidal في الأصل صار في عندي
+
+506
+00:35:02,010 --> 00:35:05,690
+خلية صغيرة في الداخل وهي عبارة عن نتج انقسم النواء
+
+507
+00:35:05,690 --> 00:35:08,690
+اندماج النواء الذكرية مع الأنثوية فقدرت تكون خلية
+
+508
+00:35:08,690 --> 00:35:12,870
+بعد كده الخلية تحت القسم اللاتنتين وهي داخلجدار
+
+509
+00:35:12,870 --> 00:35:16,370
+البويضة والتنتير حيصيروا 4 والاربع حيصيروا 16 كل
+
+510
+00:35:16,370 --> 00:35:20,030
+خلية من هذه الخلايا بنسميها Plastomera فلازم يكون
+
+511
+00:35:20,030 --> 00:35:24,430
+انا عندى في اليوم التانى اربع خلايا بنسميها four
+
+512
+00:35:24,430 --> 00:35:28,050
+embryonic cells او four Plastomera دول ال four
+
+513
+00:35:28,050 --> 00:35:31,610
+Plastomera لازم يكونوا متمثلين في الحجم ومافيش
+
+514
+00:35:31,610 --> 00:35:33,970
+عندهم حجة بنسميها no multinucleation
+
+515
+00:35:33,970 --> 00:35:37,130
+والpsychoplasm of each Plastomera should be pale
+
+516
+00:35:37,130 --> 00:35:41,730
+and clear sometime some granulationوالـ
+
+517
+00:35:41,730 --> 00:35:45,250
+fragmentation should be appeared around 20% وفي
+
+518
+00:35:45,250 --> 00:35:48,430
+اليوم التاني او اليوم التالت بقدر انا اقيم الجنين
+
+519
+00:35:48,430 --> 00:35:53,850
+الى grade 1 و2 و3 و4 1 هو الأفضل على الإطلاق بيكون
+
+520
+00:35:53,850 --> 00:35:57,790
+الخلايا الأربع بلاستوميرة الموجودة جوا متماثلة في
+
+521
+00:35:57,790 --> 00:36:03,410
+الحجم مافي عندي متماثلين في الحجم equal in the
+
+522
+00:36:03,410 --> 00:36:05,870
+size no cytoplasmic fragmentation in the result
+
+523
+00:36:05,870 --> 00:36:09,960
+يعني بمعنى أخر الأربع خلاياعبارة عن خلايا متمثلة
+
+524
+00:36:09,960 --> 00:36:12,800
+في الحجم بشكل كبير جدا والـ Fragmentation غير
+
+525
+00:36:12,800 --> 00:36:16,140
+موجود داخل الـ Cytoplasm فبسميها grade 1 وهي أفضل
+
+526
+00:36:16,140 --> 00:36:20,280
+أنواع على الإطلاق grade 2 بتكون الخلايا إلى حد ما
+
+527
+00:36:20,280 --> 00:36:24,320
+مختلفة اختلاف بسيط وفيه Cytoplasm Fragmentation
+
+528
+00:36:24,320 --> 00:36:28,900
+بسيط grade 3 الخلايا مختلفة في الحجم وفي عند الـ
+
+529
+00:36:28,900 --> 00:36:32,720
+Fragmentation واضح grade 4 الخلايا غير متمثلة في
+
+530
+00:36:32,720 --> 00:36:37,140
+الحجم و Fragmentation عالي جدا جدا جداطب انا لما
+
+531
+00:36:37,140 --> 00:36:40,940
+بدى ارجع لرحمة سيدة ارجع grade one ولا اتنين ولا
+
+532
+00:36:40,940 --> 00:36:45,460
+تلاتة ولا اربع برجع grade واحد على كل الأوجه مافيش
+
+533
+00:36:45,460 --> 00:36:49,680
+برجع grade اتنين مافيش برجع grade تلاتة ولكن اول
+
+534
+00:36:49,680 --> 00:36:53,160
+chance عندي لازم ارجع grade واحد و grade اتنين
+
+535
+00:36:53,160 --> 00:36:56,400
+طبعا في اليوم التالت لازم يصير عند الأربع خلايا
+
+536
+00:36:56,400 --> 00:36:59,660
+تصير تمان خلايا وفي اليوم الرابع التمان خلايا لازم
+
+537
+00:36:59,660 --> 00:37:05,280
+يصيروا ستة عشر خلية عشان كده عمليت انقسامخلية تصبح
+
+538
+00:37:05,280 --> 00:37:10,860
+2 و 2 يصبح 4 و 4 يصبح 8 و 8 يصبح 16 و 16 يصبح 32 و
+
+539
+00:37:10,860 --> 00:37:16,100
+32 يصبح 64 .. و هكذافي اليوم التالت اللي حكينا فيه
+
+540
+00:37:16,100 --> 00:37:20,420
+ان عدد الخلايا لازم تصير 8 خلايا بنسمي هذا ال
+
+541
+00:37:20,420 --> 00:37:24,520
+stage موريلا موريلا stage وهي عبارة عن مرحلة من
+
+542
+00:37:24,520 --> 00:37:28,160
+مراحل تطور انقسام الجنين حيث تصل عدد الخلايا فيه
+
+543
+00:37:28,160 --> 00:37:34,400
+إلى 8 خلايا على الإطلاق 8 plus 2 ميرة 8 plus 2
+
+544
+00:37:34,400 --> 00:37:40,180
+ميرة بنسمي ال structure ككل موريلا طبعابعض ال ..
+
+545
+00:37:40,180 --> 00:37:43,900
+هدف يسموها Morella
+
+546
+00:37:43,900 --> 00:37:49,240
+The pre-embryo is around 60 cell stage شو معناها؟
+
+547
+00:37:49,240 --> 00:37:53,380
+أنا ما بقدر أسمي الخلايا هذه اللي كانت تمانية و
+
+548
+00:37:53,380 --> 00:37:56,960
+اللي كانت أربع و اللي كانت اتنين ماقدرش أسميها
+
+549
+00:37:56,960 --> 00:38:03,720
+embryo بقدر أسميها 2PN بقدر أسميها زي God بقدر
+
+550
+00:38:03,720 --> 00:38:09,430
+أسميها Plastomere إذا كانت أربع خلاياولكن لما تصل
+
+551
+00:38:09,430 --> 00:38:14,230
+أعتاب ال 16 خلية في اليوم الرابع ببدأ أسميها
+
+552
+00:38:14,230 --> 00:38:17,750
+embryo ببدأ أسميها embryo يعني حتى في اليوم التاني
+
+553
+00:38:17,750 --> 00:38:21,610
+.. التالت لما صار في عندي 8 خلايا ما بقدر أسميها
+
+554
+00:38:21,610 --> 00:38:25,810
+embryo بسميها موريلا لما اتصل أعتاب ال 16 خلية
+
+555
+00:38:25,810 --> 00:38:30,470
+ببدأ أسميها embryo ببدأ أسميها embryo طبعا هي عندي
+
+556
+00:38:30,880 --> 00:38:34,680
+بداية رسمة بتوضح الكلام اللي أنا حكيته انا عندي
+
+557
+00:38:34,680 --> 00:38:38,380
+الخلية او ال void المخصبة بعد ما اتخصبت صارت اسمها
+
+558
+00:38:38,380 --> 00:38:44,540
+zygote لإنها عندي two PN في المنتصف و close مع بعض
+
+559
+00:38:44,540 --> 00:38:48,880
+البعض فبسم الخلية ككل zygote هذه الخلية انقسمت إلى
+
+560
+00:38:48,880 --> 00:38:53,480
+two cell في اليوم الأول بعدين صارت أربع خلايا في
+
+561
+00:38:53,480 --> 00:38:56,260
+اليوم التاني في اليوم التالت صارت تمان خلايا
+
+562
+00:38:56,260 --> 00:39:00,950
+سميتها morellaبعد كده التمن خلية هيصيروا 16 خلية و
+
+563
+00:39:00,950 --> 00:39:05,510
+ال 16 هيصيروا 32 خلية بسميها بعد ال 16 خلية بسميها
+
+564
+00:39:05,510 --> 00:39:12,050
+Plastocyst و لما اتصل الى 16 خلية ببدأ أسميها
+
+565
+00:39:12,050 --> 00:39:16,860
+Imperium بشكل كامل صورة بتوضحالكلام اللي احنا
+
+566
+00:39:16,860 --> 00:39:21,820
+حكيناه بشكل اخر هي انا عندي ال mature oocyte
+
+567
+00:39:21,820 --> 00:39:26,200
+صارلها fertilization أدت إلى حدوث zygote ال zygote
+
+568
+00:39:26,200 --> 00:39:29,360
+صارت two cell في اليوم الأول أربع في اليوم التاني
+
+569
+00:39:29,360 --> 00:39:32,840
+تمانية في اليوم التالت وهي الموريلا أو من تمانية
+
+570
+00:39:32,840 --> 00:39:36,540
+إلى ستاشر بعض الأحيان بيسموها وplastocyst إذا كانت
+
+571
+00:39:36,540 --> 00:39:39,640
+بعد عتاب ستاشر خلية يعني لما انا أجي أقولك
+
+572
+00:39:39,640 --> 00:39:43,060
+الموريلا عدد خلاياها بتقوللي الموريلا هي عبارة عن
+
+573
+00:39:43,060 --> 00:39:45,990
+مركبأو عبارة عن خلية أو عبارة عن الـ structure
+
+574
+00:39:45,990 --> 00:39:49,690
+يظهر في اليوم التالت من القسام من بعد عملية ال
+
+575
+00:39:49,690 --> 00:39:54,990
+fertilization تحتوي على 8 ل 16 خلية لبساطة جدا
+
+576
+00:39:54,990 --> 00:39:58,290
+لازم يكون على شكل ال range خلّيني أشوف كيف بيصير
+
+577
+00:39:58,290 --> 00:40:06,070
+عملية ال cleavage لل embryo بفيديو بسيط جدا طبعا
+
+578
+00:40:06,070 --> 00:40:10,650
+هذه عملية ال cleavage اتكلم عليها من البداية في
+
+579
+00:40:10,650 --> 00:40:14,280
+اليوم الأول والتاني والتالت والرابعهذه الواجهة
+
+580
+00:40:14,280 --> 00:40:16,940
+فيها انت خلية اتنين تلاتة اربع خلايا خمس خلايا
+
+581
+00:40:16,940 --> 00:40:21,880
+صاروا ستة اذا سبعة في اليوم التالت لازم يصلوا ل
+
+582
+00:40:21,880 --> 00:40:34,700
+تمام خلايا على كل خلية بتاعة اتنين هذه القصة هذه
+
+583
+00:40:34,700 --> 00:40:37,780
+طبعا ال stage of memorella مابتقدر تميز الخلايا و
+
+584
+00:40:37,780 --> 00:40:45,920
+هنتكلم عنها الصفات كل stage من different phasesالـ
+
+585
+00:40:45,920 --> 00:40:49,060
+Plastocyst Formation نفسنا نستطيع أن نقول إنها
+
+586
+00:40:49,060 --> 00:40:53,980
+خلية منفصلة عن الأخرى فلس ال line اختفت مباشرة
+
+587
+00:40:53,980 --> 00:40:55,440
+الحدود اختفت
+
+588
+00:41:05,760 --> 00:41:09,100
+أوريلا بدأت تزيد في الحجم تحت مصطلح expand عشان
+
+589
+00:41:09,100 --> 00:41:13,120
+تزيد حجمها بعد كده الحدود الخارجية اللي كانت خاصة
+
+590
+00:41:13,120 --> 00:41:17,500
+بالـ Oocyte مابتقدر تستحمل كمية الضغط الموجود بفعل
+
+591
+00:41:17,500 --> 00:41:21,240
+تمدد البلاستوكست فبدها نوع من أنواع الفجوات تتصير
+
+592
+00:41:21,240 --> 00:41:27,680
+عشان يصيرها releasing وزيادة في التمددطبعا هذه
+
+593
+00:41:27,680 --> 00:41:32,800
+امارة عن صورة بتوضح ليه عملية الـ Cleavage في
+
+594
+00:41:32,800 --> 00:41:36,420
+اليوم الخامس والسادس اللي بنتسميه Plastocyst Stage
+
+595
+00:41:36,420 --> 00:41:41,080
+بيحدث أو تصل الخلية أو البويضة المخصبة إلى الـ
+
+596
+00:41:41,080 --> 00:41:46,900
+Plastocyst Stage المفروض بعد 112 ساعة إلى 114 ساعة
+
+597
+00:41:46,900 --> 00:41:50,160
+من عملية ال injection هذا في الوضع الطبيعييعني في
+
+598
+00:41:50,160 --> 00:41:53,620
+الوضع الطبيعي صار ال injection الساعة ستة صباحا أو
+
+599
+00:41:53,620 --> 00:41:57,860
+ستة مساء عيد 112 ساعة المفروض الخلية تكون وصلت
+
+600
+00:41:57,860 --> 00:42:02,940
+لبلاستوست أو وصلت لليوم الخامس البلاستوست has two
+
+601
+00:42:02,940 --> 00:42:06,000
+..يعني البلاستوست بشكل أساسي في عندها نوعين من
+
+602
+00:42:06,000 --> 00:42:09,440
+الخلايا الخلية الكبيرة هذه اللي صار فيها expansion
+
+603
+00:42:09,440 --> 00:42:12,760
+في الفيديو السابق بيصير فيها نوعين من الخلايا
+
+604
+00:42:12,760 --> 00:42:15,640
+الخلية الأولى بنسميها inner cell mass والخلاية
+
+605
+00:42:15,640 --> 00:42:21,580
+التانية بنسميها differentiatedوكل خلية مسؤولة عن
+
+606
+00:42:21,580 --> 00:42:26,000
+إنتاج نوع من أنواع الخلايا الموجودة في أجسامنا في
+
+607
+00:42:26,000 --> 00:42:30,340
+عندي مرحلتين من الـplasticist المرحلة الأولى هي
+
+608
+00:42:30,340 --> 00:42:33,200
+عبارة عن ال early plasticist والتانية ال later
+
+609
+00:42:33,200 --> 00:42:38,660
+plasticist ال early ال embryo بيظل كما هو the same
+
+610
+00:42:38,660 --> 00:42:44,560
+size and zona has its same thickness في مرحلة ال
+
+611
+00:42:44,560 --> 00:42:49,090
+early ال embryo بيكونحجمه كما هو ثابت مافي عندى
+
+612
+00:42:49,090 --> 00:42:52,010
+زيادة في الحجم والزناب اللي سيدة بتكون لها نفس ال
+
+613
+00:42:52,010 --> 00:42:56,050
+thickness ما اتغيرت عشان كده لسه مادخلتش في مرحلة
+
+614
+00:42:56,050 --> 00:43:01,130
+التمددPlastocyst cavity beginning to enlargement
+
+615
+00:43:01,130 --> 00:43:04,710
+في نهاية هذه ال stage بيصير انديسيل beginning to
+
+616
+00:43:04,710 --> 00:43:08,070
+distinction into outer layer سميتها trophoplast و
+
+617
+00:43:08,070 --> 00:43:12,230
+inner layer في ال later stage ال embryo بيبدأ في
+
+618
+00:43:12,230 --> 00:43:16,070
+الزيادة في الحجم اللي سميتها الزيادة في الحجم أو
+
+619
+00:43:16,070 --> 00:43:18,130
+ال expansion بنسميها زيادة في الحجم أو ال
+
+620
+00:43:18,130 --> 00:43:24,150
+expansionباليو سيدا بتبدأ تكون أخف من حيث الصمك
+
+621
+00:43:24,150 --> 00:43:29,870
+علشان تبدأ السماح للخلايا أنها تخرج وتتمدد و ال
+
+622
+00:43:29,870 --> 00:43:33,610
+plastic coal and inner cell mass become large و
+
+623
+00:43:33,610 --> 00:43:40,350
+هذا كلام مش كتير حنهتم فيه في آخر في آخر فقرة أنا
+
+624
+00:43:40,350 --> 00:43:44,960
+بهمنيإنه زيادة في الحجم و الـ zoonableucida ببدأ
+
+625
+00:43:44,960 --> 00:43:48,860
+في عملية thinner من حيث ال sickness الخاص فيها
+
+626
+00:43:48,860 --> 00:43:53,840
+صورة بتوضح ال embryonic stem cell في اليوم الأول و
+
+627
+00:43:53,840 --> 00:43:57,000
+بعدين اليوم التاني و بعدين اليوم التالت و الرابع و
+
+628
+00:43:57,000 --> 00:44:00,360
+الخامس أو من الخامس ل السابع طبعا هذه الخلية اللي
+
+629
+00:44:00,360 --> 00:44:03,100
+في الداخل بنسميها embryonic stem cell
+
+630
+00:44:06,550 --> 00:44:09,850
+تحتوي على مادة وراثية تشبه المادة الوراثية التي
+
+631
+00:44:09,850 --> 00:44:13,230
+سوف تظهر عند الجنين فبالتالي لو أنا أخذت خلية
+
+632
+00:44:13,230 --> 00:44:16,810
+واحدة منهم ممكن أشخص الجنين هل هو male أو female؟
+
+633
+00:44:16,810 --> 00:44:20,010
+وإيش طبيعة الأمراض الوراثية اللي ممكن تظهر عنده؟
+
+634
+00:44:20,010 --> 00:44:23,130
+هذه ال embryonic stem cell تعتبر polypotence إيش
+
+635
+00:44:23,130 --> 00:44:27,370
+يعني polypotence؟ يعني تستطيع أن تعطي أي نوع من
+
+636
+00:44:27,370 --> 00:44:31,150
+أنواع القلاي الموجودة في أجسامنا هذه بنسميها
+
+637
+00:44:31,150 --> 00:44:37,510
+polypotence cellصورة أخرى تتكلم عن عملية الانقسام
+
+638
+00:44:37,510 --> 00:44:42,090
+طبعا هذه ال fertilized egg الموجودة على اليسار
+
+639
+00:44:42,090 --> 00:44:45,910
+بالأعلى صار عندي two cell في اليوم الأول four cell
+
+640
+00:44:45,910 --> 00:44:51,750
+ات cell صار في عندي خلايا متداخلة مع بعض البعض
+
+641
+00:44:51,750 --> 00:44:55,170
+مختفية الحدود ما بينهم هي ال morella و الموريلا
+
+642
+00:44:55,170 --> 00:44:58,270
+هتنقسم فيما بعد للوصول الى ال early stage من ال
+
+643
+00:44:58,270 --> 00:45:01,940
+plastocystو ال later stage من ال blastocyst في
+
+644
+00:45:01,940 --> 00:45:07,800
+اليوم الخامس إلى اليوم السابع إذا أنا خلصت مراحل
+
+645
+00:45:07,800 --> 00:45:11,980
+ال cleavage الخاصة بيهالـ embryo هنتكلم عنها بشكل
+
+646
+00:45:11,980 --> 00:45:15,940
+آخر في ال chapter القادم كيف يمكن أن نحصل على
+
+647
+00:45:15,940 --> 00:45:19,960
+بيوبسي من ال embryo لتشخيص بعض الأمراض الوراثية
+
+648
+00:45:19,960 --> 00:45:24,240
+كيف يمكن تشخيص الأمراض الوراثية من خلال الحصول على
+
+649
+00:45:24,240 --> 00:45:29,560
+embryonic biopsy أو embryo biopsy أو الحصول على
+
+650
+00:45:29,560 --> 00:45:33,390
+بيوبسي من ال polar، بنسميه polar body biopsyطبعا
+
+651
+00:45:33,390 --> 00:45:37,550
+مش هبترخص فيه، هنتكلم فيه بالإضافة إلى ال sex
+
+652
+00:45:37,550 --> 00:45:41,850
+determination أو ال gender selection في مصطلح جديد
+
+653
+00:45:41,850 --> 00:45:45,330
+بيستخدموه في مصطلح جديد بيستخدموه وهو عبارة عن ال
+
+654
+00:45:45,330 --> 00:45:50,170
+IUI وهو عبارة عن ال intrauterine insemination يعني
+
+655
+00:45:50,170 --> 00:45:54,970
+بمعنى آخر الحقن داخل الرحم طبعا هذا مصطلح يستخدم
+
+656
+00:45:54,970 --> 00:45:58,770
+في حالات معينة عند .. عند couples اللي هم مشكلة في
+
+657
+00:45:58,770 --> 00:46:04,260
+معينة بمعنى أنه ال male طبيعيةالفميل الطبيعي ولكن
+
+658
+00:46:04,260 --> 00:46:07,340
+ال spermatozoa الموجودة بعد عملية ال ejaculation
+
+659
+00:46:07,340 --> 00:46:13,700
+inside the vagina بيصير عنده مشكلة في وصول
+
+660
+00:46:13,700 --> 00:46:18,920
+ال spermatozoa إلى ال fallopian tube هنا عبارة عن
+
+661
+00:46:18,920 --> 00:46:23,390
+المشكلةطبعا في هذا النوع من أنواع ال «couples» أو
+
+662
+00:46:23,390 --> 00:46:25,610
+هؤلاء المشاكل اللي بتواجه ال «couples» بيكون فيه
+
+663
+00:46:25,610 --> 00:46:27,790
+أنا عند ال «couples» عادة من حيث عدد ال
+
+664
+00:46:27,790 --> 00:46:32,010
+spermatozoa أو ال morphology ولكن بعد عملية ال
+
+665
+00:46:32,010 --> 00:46:34,790
+ejaculation inside the vagina في مشاكل بتواجه ال
+
+666
+00:46:34,790 --> 00:46:38,490
+spermatozoa ما بتقدر تخترق ال cervix خصوصا إذا كان
+
+667
+00:46:38,490 --> 00:46:42,410
+عند الفيميل ant sperm antibodyأو في عندها مشكلة في
+
+668
+00:46:42,410 --> 00:46:46,610
+عملية .. في الـ mucus الموجود في منطقة الـ cervic
+
+669
+00:46:46,610 --> 00:46:49,730
+أو في عنده مشكلة في الـ pH فبتقتل ال spermatozoa
+
+670
+00:46:49,730 --> 00:46:54,950
+فالطبيب بيجي بحكم كمية كبيرة جدا من ال spermatozoa
+
+671
+00:46:54,950 --> 00:46:58,810
+بقى في الرحل مباشرة في الرحل المباشرة عشان يقلل
+
+672
+00:46:58,810 --> 00:47:03,810
+فرصة تعرض ال spermatozoa إلى الأخطار التي يمكن أن
+
+673
+00:47:03,810 --> 00:47:07,520
+تتعرض لها أثناء عملية دخول ال cervicواختراف منطقة
+
+674
+00:47:07,520 --> 00:47:11,760
+الـ cervic و بيقصر المسافة اللي ممكن يقطعها ال
+
+675
+00:47:11,760 --> 00:47:14,760
+spermatozoa وصولا إلى ال fallopian tube هذه مصطلح
+
+676
+00:47:14,760 --> 00:47:20,160
+بنسميه IUI Intra-Uterine insemination is a
+
+677
+00:47:20,160 --> 00:47:22,720
+fertility treatment that involve placing
+
+678
+00:47:22,720 --> 00:47:26,600
+spermatozoa inside women uterus to facilitate
+
+679
+00:47:26,600 --> 00:47:30,360
+fertilization يعني ال spermatozoa يتم وضعها في
+
+680
+00:47:30,360 --> 00:47:34,500
+الرحم ولا يتم وضع في ال fallopian tubeالسبيرمتازوه
+
+681
+00:47:34,500 --> 00:47:37,260
+بعد ما يوضع في الرحم هو اللي هيروح ويهاجر للـ
+
+682
+00:47:37,260 --> 00:47:44,720
+Fallopian tube طبعا متى بتتم النصح بعمل I.O.I؟ هل
+
+683
+00:47:44,720 --> 00:47:48,340
+كل إنسان ممكن يعمل I.O.I؟ ولا لازم كابلز لهم صفات
+
+684
+00:47:48,340 --> 00:47:52,120
+معينة؟ لأ أكيد لازم يكون كابلز لهم صفات معينة منهم
+
+685
+00:47:52,120 --> 00:47:58,320
+ال I.O.I يعتبر inexpensive إلى حد ما يعتبر غير
+
+686
+00:47:58,320 --> 00:48:03,570
+مكلف لأن مافي أدوية تاخدها السيدةما في أدوية
+
+687
+00:48:03,570 --> 00:48:06,650
+بتعالج مشكلة معينة عند السيدة الخاصة السيدة ما
+
+688
+00:48:06,650 --> 00:48:10,850
+عندها مشكلة في ال ovulation ال I.O.I يعتبر أول
+
+689
+00:48:10,850 --> 00:48:16,090
+chance أو أول فكرة أو أول حل في وجه الأطباء و لازم
+
+690
+00:48:16,090 --> 00:48:21,310
+يعملوه قبل ما يروحوا إلى الإجزي بشكل مباشر ال I.O
+
+691
+00:48:21,310 --> 00:48:26,770
+.I يوصف للسيدات اللي عندهم مشاكل في منطقة ال
+
+692
+00:48:26,770 --> 00:48:31,530
+cervical نسميها cervical scar ال tissue اللي بتمنع
+
+693
+00:48:31,800 --> 00:48:36,200
+وصول الـ spermatozoa إلى الرحم فبالتالي تفقد
+
+694
+00:48:36,200 --> 00:48:41,740
+الفرصة على أو في الإنجاب تفقد الفرصة في الإنجاب
+
+695
+00:48:41,740 --> 00:48:46,300
+هذا بالنسبة لل IOI شغلة تانية ال IOI يوصف لبعض
+
+696
+00:48:46,300 --> 00:48:49,340
+الحالات اللي عندهم mild male factor infertility
+
+697
+00:48:49,340 --> 00:48:53,160
+unexplained infertility الناس اللي يعتبروا
+
+698
+00:48:53,160 --> 00:48:56,020
+infertile بسبب جهاز المناع اللي بتسميه
+
+699
+00:48:56,020 --> 00:48:59,640
+immunological infertilityالناس اللي عندهم مشاكل في
+
+700
+00:48:59,640 --> 00:49:02,880
+ال ejaculation .. okay فيه spermatozoa بيصير
+
+701
+00:49:02,880 --> 00:49:06,280
+intercourses ولكن المشكلة في ال ejaculation ما
+
+702
+00:49:06,280 --> 00:49:11,160
+بيصلّى الحد المسموح فيه فبالتالي كمية و عدد ال
+
+703
+00:49:11,160 --> 00:49:13,660
+spermatozoa اللي بتصل لل cervic و تستطيع تخترق ال
+
+704
+00:49:13,660 --> 00:49:18,040
+cervic بتكون قليلة جدا طبعا هتتدمر و تتلف أثناء
+
+705
+00:49:18,040 --> 00:49:20,740
+الرحلة الطويلة فبالتالي فرصة ال fertilization
+
+706
+00:49:20,740 --> 00:49:24,500
+ضعيفة الناس اللي عندها endomateriosis اللي عندهم
+
+707
+00:49:24,500 --> 00:49:30,780
+ovarian dysfunctionمشاكل في التبيول if the male
+
+708
+00:49:30,780 --> 00:49:34,840
+parent sperm count motility or shape is less than
+
+709
+00:49:34,840 --> 00:49:38,680
+adequate or normal if the female cervical mucous
+
+710
+00:49:38,680 --> 00:49:43,600
+is very thick IUI will allow the spermto transfer
+
+711
+00:49:43,600 --> 00:49:49,620
+and overcome the mucus في فحص بيسموه PCT مهم جدا
+
+712
+00:49:49,620 --> 00:49:56,840
+هذا الفحص و هو ال postcoital test أو بمعنى فحص ما
+
+713
+00:49:56,840 --> 00:50:01,740
+بعد الجبع ببساطة جدا يستخدم إذا كان في عند ال
+
+714
+00:50:01,740 --> 00:50:07,120
+couples مشكلة في انتقال ال spermatozoa و اختراق
+
+715
+00:50:07,120 --> 00:50:13,640
+منطقة ال cervicالطبيب أو الطبيبة بيطلب من الـ
+
+716
+00:50:13,640 --> 00:50:17,880
+couples إنهم يعملوا فحص الـ BCT بيصير interaction
+
+717
+00:50:17,880 --> 00:50:20,360
+و intercourse بيبقى بين ال two couples بعدين
+
+718
+00:50:20,360 --> 00:50:23,000
+الطبيبة بتيجي و بتاخد swap مباشرة بعد ال
+
+719
+00:50:23,000 --> 00:50:28,500
+intercourse من منطقة ال cervic بتقسمها part one
+
+720
+00:50:28,500 --> 00:50:32,370
+part two part threeوبتشوف وين ال spermatozoa هل ال
+
+721
+00:50:32,370 --> 00:50:35,250
+spermatozoa أخر part تواجد فيها part 1 فبالتالي
+
+722
+00:50:35,250 --> 00:50:38,770
+part 2 و part 2 part 2 و part 3 مافيها spermatozoa
+
+723
+00:50:38,770 --> 00:50:42,730
+في في part 1 و part 2 وفيش في part 3 فمعناه بتحدد
+
+724
+00:50:42,730 --> 00:50:46,210
+المسافة أو أقصى مسافة ممكن تقطعها ال spermatozoa
+
+725
+00:50:46,210 --> 00:50:51,650
+وبناء عليه ممكن تحدد هل تحتاج إلى IOI أم تحتاج إلى
+
+726
+00:50:51,650 --> 00:50:57,590
+IVF أم تحتاج إلى ECG ولكن ال IOI في الغالببيستخدم
+
+727
+00:50:57,590 --> 00:51:01,950
+لـ two couples normal بشكل عام جدا ال female ما
+
+728
+00:51:01,950 --> 00:51:04,370
+عندها أي مشاكل هرمونية ما عندها مشاكل في الطويد ما
+
+729
+00:51:04,370 --> 00:51:08,130
+عندها مشاكل في عدد البويضات ال male ما عنده مشاكل
+
+730
+00:51:08,130 --> 00:51:12,070
+في عدد الحيارات ما عنده مشاكل في ال morphology ال
+
+731
+00:51:12,070 --> 00:51:16,030
+seam البراميض الطبيعي ولكن مشكلة في عملية الانتقال
+
+732
+00:51:16,030 --> 00:51:19,690
+واختراق و التغلب على منطقته و العواقق الموجودة في
+
+733
+00:51:19,690 --> 00:51:23,190
+منطقة ال cervic للوصول إلى الleotard هذا المشكلة
+
+734
+00:51:23,190 --> 00:51:29,310
+الوحيدة المشكلة تحل باستخدامالـ I&I إلى حد ما I&I
+
+735
+00:51:29,310 --> 00:51:33,370
+involve pre-procedure evaluation including
+
+736
+00:51:33,370 --> 00:51:36,550
+physical clinical lab evaluation of to determine
+
+737
+00:51:36,550 --> 00:51:40,790
+the duration and causes of infertility, semen
+
+738
+00:51:40,790 --> 00:51:44,410
+quality, functional tubule status and follicular
+
+739
+00:51:44,410 --> 00:51:49,210
+and uterine status يعني أي two couples بدون يخضعوا
+
+740
+00:51:49,210 --> 00:51:52,690
+للـ I&I لازم يخضعوا لعملية evaluation قبل كل شيء
+
+741
+00:51:52,690 --> 00:51:56,640
+عشان يحددوا الـ semen parameter equality ككفيةيحدد
+
+742
+00:51:56,640 --> 00:51:59,900
+ال duration لل infertility و أسبابها كيف ال
+
+743
+00:51:59,900 --> 00:52:02,900
+function بتاعة ال ovary الخاصة بالسيدة هو بيعي مش
+
+744
+00:52:02,900 --> 00:52:06,400
+طبيعي؟ في مشكلة في ال tubule ولا لأ؟ و ال follicle
+
+745
+00:52:06,400 --> 00:52:09,980
+كيف وضعها؟ و الرحم كيف وضعه؟ ممكن يبني بطانة الرحم
+
+746
+00:52:09,980 --> 00:52:11,960
+فيها inflammation؟ مش فيها inflammation؟ فيها
+
+747
+00:52:11,960 --> 00:52:16,460
+infection؟ أمر طبيعي جدا لأنه مش منطق الطبيب يروح
+
+748
+00:52:16,460 --> 00:52:21,040
+يعمل I.O.I و تكون المشكلة أصلا مش في عملية التغلب
+
+749
+00:52:21,040 --> 00:52:23,220
+و قطع مسافة ال cervical يكون المشكلة في
+
+750
+00:52:29,900 --> 00:52:34,500
+لازم يكون كل شيء طبيعي باستثناء المسافة التي سوف
+
+751
+00:52:34,500 --> 00:52:39,240
+يقطعها ال spermatozoon للتغلب علىمنطقة الـ cervic
+
+752
+00:52:39,240 --> 00:52:42,240
+ساعتها انا بقدر اقول والله هدولة ال couples
+
+753
+00:52:42,240 --> 00:52:46,620
+هيحتاجوا الى IUI control ovarian hyper stimulation
+
+754
+00:52:46,620 --> 00:52:50,380
+with close monitoring of leukogenesis and
+
+755
+00:52:50,380 --> 00:52:54,300
+ovulation to avoid a side effect like ovarian
+
+756
+00:52:54,300 --> 00:52:56,700
+hyper stimulation syndrome حتى السيدات اللي
+
+757
+00:52:56,700 --> 00:53:01,140
+هيخضعوا على ال IUI نادر مايروحوا يعملوا induction
+
+758
+00:53:01,140 --> 00:53:05,760
+يعملوا stimulation لأن وضعهم طبيعي ولكن في بعض
+
+759
+00:53:05,760 --> 00:53:09,980
+الأحيان علشانيكون عندى فرصة نجاح عالية جدا بعمل
+
+760
+00:53:09,980 --> 00:53:15,000
+stimulation خفيف مسيطر عليه عشان اتجنب اي ovarian
+
+761
+00:53:15,000 --> 00:53:21,140
+hyper stimulation syndrome as side effect ال IOI
+
+762
+00:53:21,140 --> 00:53:25,160
+is preferred conception enhancing technique for
+
+763
+00:53:25,160 --> 00:53:30,080
+women less than 35 years functional tube short
+
+764
+00:53:30,080 --> 00:53:34,430
+period of infertility moderatemale infertility هذا
+
+765
+00:53:34,430 --> 00:53:39,270
+أكثر الشخصيات اللي ينصح لهم أن عمر السيدة أقل من
+
+766
+00:53:39,270 --> 00:53:42,770
+35 تبعه اللي عندنا normal من حيث ال functional و
+
+767
+00:53:42,770 --> 00:53:45,810
+ال structure ال infertility time و duration قصيرة
+
+768
+00:53:45,810 --> 00:53:51,810
+جدا و infertility severity عند ال male moderate or
+
+769
+00:53:51,810 --> 00:53:56,380
+mildطبعا بالنسبة لل IOI cycle perform before
+
+770
+00:53:56,380 --> 00:54:00,300
+consider alternative therapy such as IVF إذا فشل
+
+771
+00:54:00,300 --> 00:54:07,360
+ال IOI بتروح سيدة لل IVF فشلة ال IVF بتروح لعمليات
+
+772
+00:54:07,360 --> 00:54:12,440
+LHZ هذا المنطقه يقول كده طبعا في عندي بعض المعوقات
+
+773
+00:54:12,440 --> 00:54:17,660
+أو خليني أسميها contraindication
+
+774
+00:54:17,660 --> 00:54:21,180
+ال IOI may be contraindication in women with sperm
+
+775
+00:54:21,180 --> 00:54:24,800
+immunoimmobilized antibody في بعض الأحيان بعض
+
+776
+00:54:24,800 --> 00:54:32,340
+التحذيرات ال I.O.I مهم جدا انه يستخدم للتغلب على
+
+777
+00:54:32,340 --> 00:54:35,800
+المشاكل التي تظهر عند السيدات إذا كانت المشاكل لها
+
+778
+00:54:35,800 --> 00:54:40,420
+علاقة بجهاز المنع بجهاز المنع ال antibody secreted
+
+779
+00:54:40,420 --> 00:54:42,380
+in the female reproductive tract that may be
+
+780
+00:54:42,380 --> 00:54:45,960
+impaired sperm passage inhibit fertilization and
+
+781
+00:54:45,960 --> 00:54:48,880
+prevent normal post fertilization process و هذا
+
+782
+00:54:48,880 --> 00:54:54,220
+الكلام اتكلمنا عنه انه من اهمالمشاكل التي تؤدي إلى
+
+783
+00:54:54,220 --> 00:54:59,520
+اللجوء لل IOI وجود antibody ضد الـ spermatozoa عند
+
+784
+00:54:59,520 --> 00:55:02,940
+الفيماية عند الفيماية troubles with severe male
+
+785
+00:55:02,940 --> 00:55:08,480
+factor abnormal pelvic anatomy cannot be performed
+
+786
+00:55:08,480 --> 00:55:12,040
+or corrected by micro surgical repair يعني بعض
+
+787
+00:55:12,040 --> 00:55:16,360
+السيدات بيكون عندهم ال pelvic anatomy غير طبيعي
+
+788
+00:55:17,370 --> 00:55:21,090
+فبالتالي لا يمكن تعديله بعملية جراحية فبترجع إلى
+
+789
+00:55:21,090 --> 00:55:24,230
+ال IUI شو بيصير في ال insemination شو بيصير في ال
+
+790
+00:55:24,230 --> 00:55:28,750
+IUI ببساطة جدا بيقول ليه انه is pre-performed at
+
+791
+00:55:28,750 --> 00:55:33,510
+the time of ovulation usually 24 to 36 hours after
+
+792
+00:55:33,510 --> 00:55:38,150
+LH surge or peak is detected or after trigger
+
+793
+00:55:38,150 --> 00:55:43,210
+injection of HCG is administrated بمعنى آخر ان ال
+
+794
+00:55:43,210 --> 00:55:49,260
+IUI بتحدث بعد عمليةأو ظهور الـ LH Peak أو الـ LH
+
+795
+00:55:49,260 --> 00:55:55,800
+Surge بوقت يقدر بـ 24 ساعة أو 36 ساعة وهي عبارة عن
+
+796
+00:55:55,800 --> 00:55:58,940
+وقت الـ ovulation إذا بتتذكروا أو إذا هو بده
+
+797
+00:55:58,940 --> 00:56:03,600
+يعملها stimulation و induction لازم تصير بعد
+
+798
+00:56:03,600 --> 00:56:08,740
+إعطاءها القبرة التفجير اللي سميناها Sheragon وهي
+
+799
+00:56:08,740 --> 00:56:14,680
+عبارة عن مادة تحتوي على الـ HCG in the case of
+
+800
+00:56:14,680 --> 00:56:17,940
+husband inseminationالمايل should be giving the
+
+801
+00:56:17,940 --> 00:56:21,720
+sample in the same day of insemination و هذه ال
+
+802
+00:56:21,720 --> 00:56:25,420
+sample لازم يصير لها analysis عشان أعرف ال
+
+803
+00:56:25,420 --> 00:56:29,680
+parameter و أعملها purification و أعملها swarm up
+
+804
+00:56:29,680 --> 00:56:32,750
+في الغالب swarm up علشان أفرزالـ Mutile
+
+805
+00:56:32,750 --> 00:56:36,130
+spermatozoa من other spermatozoa و الـ Depressed
+
+806
+00:56:36,130 --> 00:56:40,270
+بعملها إما spermatozoa swamp up process أو بعملها
+
+807
+00:56:40,270 --> 00:56:44,850
+density gradient centrifugation بعد كده باخد ال
+
+808
+00:56:44,850 --> 00:56:49,830
+spermatozoa المطيل في حاجة بنسميها flexible
+
+809
+00:56:49,830 --> 00:56:55,830
+catheter هذه ال flexible catheter الطبيب بدخلها
+
+810
+00:56:55,830 --> 00:56:59,690
+داخل ال cervica الخاص بال female و بعمل injection
+
+811
+00:56:59,690 --> 00:57:06,770
+لل spermatozoaداخل الرحمة و بعد ذلك ستبدأ رحلتها
+
+812
+00:57:06,770 --> 00:57:11,890
+للوصول الى البويضة و التخصيبات طبعا معظم الدكاترة
+
+813
+00:57:11,890 --> 00:57:14,370
+بيعملوا recommendation ان هذه السيدة اللي قامت
+
+814
+00:57:14,370 --> 00:57:17,610
+with I.O.I لازم تبقى على ال table او على السرير
+
+815
+00:57:17,610 --> 00:57:21,690
+اللي صار فيه او عملت I.O.I فيها يعني في منطقة او
+
+816
+00:57:21,690 --> 00:57:26,660
+غرفة العملياتمدة 15 إلى 30 دقيقة بعد عملية ال
+
+817
+00:57:26,660 --> 00:57:31,620
+injection علشان تسمح للـ spermatozoa بالحركة في
+
+818
+00:57:31,620 --> 00:57:35,360
+اتجاه الفانوبيا الاتيومي ال implantation إذا كانت
+
+819
+00:57:35,360 --> 00:57:40,920
+العملية صحيحة ببدأ بعد ال 6 أيام إلى 12 يوم بعد
+
+820
+00:57:40,920 --> 00:57:44,420
+عملية ال ovulation السؤال بيطرح نفسه هل يمكن
+
+821
+00:57:44,420 --> 00:57:47,420
+استخدام ال IOI إذا كانت السيدة عندها tubule
+
+822
+00:57:47,420 --> 00:57:50,920
+ligation لأ لأن ال tubule ligation معناه أن ال
+
+823
+00:57:50,920 --> 00:57:55,410
+oocyte لن تتوفرفما فيش عندي .. إيش هستفيد من عملية
+
+824
+00:57:55,410 --> 00:58:00,550
+ال I.O.I؟ Can I.O.I be used for gender selection؟
+
+825
+00:58:00,550 --> 00:58:03,630
+بالمنطق ما بقدر أستخدم ال I.O.I لل gender
+
+826
+00:58:03,630 --> 00:58:09,190
+selection إلا إذا أنا عملت injection فقط لل sperm
+
+827
+00:58:10,070 --> 00:58:14,130
+اللي بيحمل Y كرومزوم أو ال sperm X كرومزوم وهذا
+
+828
+00:58:14,130 --> 00:58:18,610
+منطق غير مقبول لأن المسافة اللي هينتقلها ويقطعها
+
+829
+00:58:18,610 --> 00:58:22,650
+ال sperm طويلة جدا فكمية كبيرة جدا هتموت من ال
+
+830
+00:58:22,650 --> 00:58:26,190
+spermatozoa المسافة اللي هيقطعها من نهاية عمق
+
+831
+00:58:26,190 --> 00:58:30,090
+الرحم حتى ال fallopian tube وهذه مسافة طويلة إلى
+
+832
+00:58:30,090 --> 00:58:36,430
+حد ما تحتاج وقت إلى حد ما طويل تتعرض لأمور كثيرة
+
+833
+00:58:36,430 --> 00:58:39,350
+ال spermatozoa اتكلمنا عنها وشوفناها في فيديوهات
+
+834
+00:58:39,350 --> 00:58:42,840
+كثيرةفبيعمل reduction لكمية كبيرة جدا من ال
+
+835
+00:58:42,840 --> 00:58:46,620
+spermatozoa الفكرة في ال I.O.I أني أضغط أكبر عدد
+
+836
+00:58:46,620 --> 00:58:50,280
+من الحيوانات المنوية المتحركة في منطقة الرحم
+
+837
+00:58:50,280 --> 00:58:53,800
+فبالتالي ما بقدر استخدمها إذا كانت عندي tubular
+
+838
+00:58:53,800 --> 00:58:58,080
+ligation وما بقدر استخدمها لل gender selection
+
+839
+00:58:58,080 --> 00:59:03,480
+طبعا صورة بتوضح عملية ال I.O.I في صورة تانية هي
+
+840
+00:59:03,480 --> 00:59:08,700
+المبيض الأيمن و الآيسر و ال fluvial tube هي الرحم
+
+841
+00:59:09,000 --> 00:59:12,700
+هي منطقة الـ vagina وهي منطقة الـ cervic الطبيب
+
+842
+00:59:12,700 --> 00:59:16,100
+بيجيب needle مشبوكة في نهيتها flexa بال catheter
+
+843
+00:59:16,100 --> 00:59:20,360
+محملة فيها ال spermatozoa بدخل من خلال ال cervic و
+
+844
+00:59:20,360 --> 00:59:24,260
+بيعمل injection ل ال spermatozoa داخل الرحم وال
+
+845
+00:59:24,260 --> 00:59:28,300
+spermatozoa تبدأ بالهجرة إلى ال fallopian tube لكي
+
+846
+00:59:28,300 --> 00:59:33,620
+تتم عملية الطلقية خلينا نشوف الفيديو اللي بتكلم عن
+
+847
+00:59:33,620 --> 00:59:35,960
+هذا الموضوع باستفادة
+
+848
+00:59:37,460 --> 00:59:40,440
+الـ sperm that has been prepared is loaded into a
+
+849
+00:59:40,440 --> 00:59:43,880
+syringe to which a catheter is attached then the
+
+850
+00:59:43,880 --> 00:59:46,220
+speculum is introduced into the vagina allowing
+
+851
+00:59:46,220 --> 00:59:48,520
+the entrance of the neck of the uterus to be made
+
+852
+00:59:48,520 --> 00:59:51,180
+visible the catheter that has been charged with
+
+853
+00:59:51,180 --> 00:59:54,020
+sperm is introduced high into the uterus and the
+
+854
+00:59:54,020 --> 00:59:56,940
+sperm ascends through the fallopian tubes arriving
+
+855
+00:59:56,940 --> 00:59:59,960
+at the area where the oocyte is located and
+
+856
+00:59:59,960 --> 01:00:04,820
+fertilization of the oocyte is facilitated طبعا
+
+857
+01:00:04,820 --> 01:00:09,950
+هذه فكرة ال IOI ببساطة جدافي فيديو تاني بتكلم عن
+
+858
+01:00:09,950 --> 01:00:17,310
+هذا الموضوع بشكل أوسع خلّينا ننظر إليه
+
+859
+01:00:17,310 --> 01:00:22,330
+Intrauterine insemination also known as artificial
+
+860
+01:00:22,330 --> 01:00:25,590
+insemination is a procedure done to help a woman
+
+861
+01:00:25,590 --> 01:00:29,870
+get pregnant a
+
+862
+01:00:29,870 --> 01:00:33,710
+woman's reproductive system includes the vagina
+
+863
+01:00:33,710 --> 01:00:36,430
+cervix
+
+864
+01:00:39,580 --> 01:00:49,580
+Uterus Fallopian tubes and ovaries During
+
+865
+01:00:49,580 --> 01:00:52,220
+the monthly menstrual cycle, one of her ovaries
+
+866
+01:00:52,220 --> 01:00:55,840
+releases an egg in a process called ovulation
+
+867
+01:00:55,840 --> 01:00:59,200
+After
+
+868
+01:00:59,200 --> 01:01:02,200
+ovulation, the egg enters the fallopian tube
+
+869
+01:01:05,080 --> 01:01:08,180
+الفتاة أكتر ممكن أن تصبح عميقة إذا كانت لديها نفس
+
+870
+01:01:08,180 --> 01:01:15,600
+في الأيام قبل فقط، خلال أو بعد عبولة. في هذا
+
+871
+01:01:15,600 --> 01:01:19,000
+الوقت، جسد عميقة من ميزة عيونية لرجل رجل مسمى
+
+872
+01:01:19,000 --> 01:01:22,400
+سيمان قادر على تفرتيز حيوانها كما يتحرك من خلال
+
+873
+01:01:22,400 --> 01:01:27,840
+محطة الفلوبيين.يمكن
+
+874
+01:01:27,840 --> 01:01:28,540
+تفعيل عملية عملية عملية عملية عملية عملية عملية
+
+875
+01:01:28,540 --> 01:01:28,600
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+876
+01:01:28,600 --> 01:01:30,260
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+877
+01:01:30,260 --> 01:01:33,540
+عملية عملية عملي
+
+878
+01:01:34,140 --> 01:01:36,920
+أو قد يكون فعله إذا كانت المرأة تريد أن تكون لديها
+
+879
+01:01:36,920 --> 01:01:43,480
+طفل بدون شركة رجل قبل
+
+880
+01:01:43,480 --> 01:01:46,540
+إدارة الانسمينة للأطفال، يمكن أن تلقى المرأة
+
+881
+01:01:46,540 --> 01:01:49,740
+مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة
+
+882
+01:01:49,740 --> 01:01:50,360
+مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة
+
+883
+01:01:50,360 --> 01:01:50,660
+مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة
+
+884
+01:01:50,660 --> 01:01:59,140
+مواجهة مواجهة مواجهة مواج
+
+885
+01:01:59,420 --> 01:02:02,260
+هذا يقوم بالتركيز في الحرارة ويقوم بإزالة الحرارة
+
+886
+01:02:02,260 --> 01:02:03,940
+ويقوم بإزالة الحرارة ويقوم بإزالة الحرارة ويقوم
+
+887
+01:02:03,940 --> 01:02:05,140
+بإزالة الحرارة ويقوم بإزالة الحرارة ويقوم بإزالة
+
+888
+01:02:05,140 --> 01:02:07,280
+الحرارة ويقوم بإزالة الحرارة ويقوم بإزالة الحرارة
+
+889
+01:02:07,280 --> 01:02:07,540
+ويقوم بإزالة الحرارة ويقوم بإزالة الحرارة ويقوم
+
+890
+01:02:07,540 --> 01:02:10,440
+بإزالة الحرارة ويقوم بإزالة الحرارة ويقوم بإزالة
+
+891
+01:02:10,440 --> 01:02:15,660
+الحرارة ويقوم بإزالة الحرارة ويقوم بإزالة الحرارة
+
+892
+01:02:15,660 --> 01:02:23,120
+ويقوم بإزالة الحرارة و
+
+893
+01:02:23,940 --> 01:02:26,780
+التجارة التجارية التجارية التجارية التجارية
+
+894
+01:02:26,780 --> 01:02:27,000
+التجارية التجارية التجارية التجارية التجارية
+
+895
+01:02:27,000 --> 01:02:28,120
+التجارية التجارية التجارية التجارية التجارية
+
+896
+01:02:28,120 --> 01:02:29,220
+التجارية التجارية التجارية التجارية التجارية
+
+897
+01:02:29,220 --> 01:02:32,420
+التجارية التجارية التجارية التجارية التجارية
+
+898
+01:02:32,420 --> 01:02:37,140
+التجارية التجارية
+
+899
+01:02:37,140 --> 01:02:39,160
+التجارية التجارية التجارية التجارية التجارية
+
+900
+01:02:39,160 --> 01:02:39,380
+التجارية التجارية التجارية التجارية التجارية
+
+901
+01:02:39,380 --> 01:02:42,340
+التجارية التجارية التجارية التجارية التجارية
+
+902
+01:02:42,340 --> 01:02:50,360
+التجارية التجارية التجارية التجارسيرينج سيتم
+
+903
+01:02:50,360 --> 01:02:52,960
+تحميله بمقدورة صغيرة من المواظب اللي تحتوي على الـ
+
+904
+01:02:52,960 --> 01:02:57,860
+Washed Sperm ثم السيرينج سيتم إضافته إلى طب قوى
+
+905
+01:02:57,860 --> 01:03:02,540
+طويل واسمه كاثاتر الدكتور سينضغط الكاثاتر في الـ
+
+906
+01:03:02,540 --> 01:03:07,060
+Vagina فأسطول الكاثاتر سيكون مدرساً من خلال فتحة
+
+907
+01:03:07,060 --> 01:03:12,080
+في الـ cervix وإلى الـ uterus عندما يكون الكاثاتر
+
+908
+01:03:12,080 --> 01:03:15,240
+داخل الـ uterus دكتوره سينجح الـ sperm
+
+909
+01:03:18,050 --> 01:03:24,630
+Then the catheter and speculum will be removedThe
+
+910
+01:03:24,630 --> 01:03:28,070
+woman may continue to lie on her back for about 10
+
+911
+01:03:28,070 --> 01:03:34,010
+minutes طبعا هذه معظم الأمور اللي بتصير خلال ال I
+
+912
+01:03:34,010 --> 01:03:37,370
+.O.I من أجل إنجاح عملية الحقن و التغلب على ال
+
+913
+01:03:37,370 --> 01:03:41,570
+infertility problem اللتي تكون عند السيدات بفعل
+
+914
+01:03:41,570 --> 01:03:44,550
+الأسباب اللتي تم ذكرها سواء كانت في الفيديو أو في
+
+915
+01:03:44,550 --> 01:03:48,680
+الشرحبهذا القدر نكتفي ونكون قد أنهينا من هذا ال
+
+916
+01:03:48,680 --> 01:03:51,520
+chapter على أمل أن نلتقي في محاضرة جديدة ب chapter
+
+917
+01:03:51,520 --> 01:03:55,560
+جديد ان شاء الله دومتم في حفظ الله و رعايته
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/KDv30k-n6FE_raw.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/KDv30k-n6FE_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..808efd0461cead79777ac1531af6744b5f462db3
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/KDv30k-n6FE_raw.srt
@@ -0,0 +1,3680 @@
+1
+00:00:01,450 --> 00:00:05,330
+باسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:05,330 --> 00:00:10,690
+المرسلين سيدنا محمد وعلى آله وصحبه أجمعين طلابنا
+
+3
+00:00:10,690 --> 00:00:15,030
+الأعزاء أرجو من الله الكريم أن تكونوا جميعا بخير
+
+4
+00:00:15,030 --> 00:00:20,110
+اليوم سوف نستكمل ما بدأنا فيه في المحاضرة السابقة
+
+5
+00:00:20,110 --> 00:00:25,170
+التي كانت بعنوان الحقن المجهري intracytoplasmic
+
+6
+00:00:25,170 --> 00:00:30,460
+sperm injection تكلمنا في المحاضرة السابقة عنأهم
+
+7
+00:00:30,460 --> 00:00:35,000
+الخطوات المتبعة في الحقن المجهري والتي تتمثل فيه
+
+8
+00:00:35,000 --> 00:00:39,740
+آلية تحضير الأطباق الخاصة بالحقن كيف يتم تحميل
+
+9
+00:00:39,740 --> 00:00:45,140
+الجميطات الأنثوية والذكرية داخل الطبق مما تتكون
+
+10
+00:00:45,140 --> 00:00:50,700
+هذه الأطباق من أوصاد زراعية كيف يمكن استخدام الزيت
+
+11
+00:00:50,700 --> 00:00:54,840
+من أجل تغطية هذه القطارات الموضوعة في ال injection
+
+12
+00:00:54,840 --> 00:01:00,220
+dish أو ال petri dishكيف يتم عمل immobilization
+
+13
+00:01:00,220 --> 00:01:03,940
+للـ spermatozoa من أجل يقاف قدرتها على الحركة
+
+14
+00:01:03,940 --> 00:01:08,800
+واستخدامها في عملية الحقن؟ كيف يمكن التفريط بين ال
+
+15
+00:01:08,800 --> 00:01:13,820
+spermatozoa الميت والحي؟ وبناء عليه نستطيع أن نقول
+
+16
+00:01:13,820 --> 00:01:17,880
+هذا الحيوان المنوي يصلح لعملية الحقن أم لا يصلح
+
+17
+00:01:17,880 --> 00:01:22,760
+اليوم سوف نستكمل باقي ما تعلق بهذا الموضوع في
+
+18
+00:01:22,760 --> 00:01:28,410
+محاضرة واحدة فقط لا غير لن نقسم المحاضرةأول عنوان
+
+19
+00:01:28,410 --> 00:01:32,790
+سوف نتحدث فيه هو عبارة عن فشل عملية الحقن المجهري
+
+20
+00:01:32,790 --> 00:01:40,210
+ثم سوف نتحدث عن فشل نتائج الحقن المجهري المعروف أن
+
+21
+00:01:40,210 --> 00:01:45,030
+الحقن المجهري نتيجته انقسام في البويضة المخصبة لكي
+
+22
+00:01:45,030 --> 00:01:54,610
+تصبح خليتين أو 4 ثم 8 ثم 16ثم 32 لكي تصلح وتصل إلى
+
+23
+00:01:54,610 --> 00:02:00,090
+اللحظة التي يمكن أن يتم إرجاعها إلى رحم السيدة من
+
+24
+00:02:00,090 --> 00:02:05,030
+أجل عمل implementation واستكمال عملية تكوين الجنين
+
+25
+00:02:05,030 --> 00:02:12,050
+ولكن Exifailure موضوع مهم جدا لا يمكن بشكل من
+
+26
+00:02:12,050 --> 00:02:15,650
+الأشكال أن نقول عملية الحقن ال major عملية ناجحة
+
+27
+00:02:15,650 --> 00:02:21,050
+إلا إذا حصلنا على true baby فبالتاليفي عندي نجاح
+
+28
+00:02:21,050 --> 00:02:26,170
+مؤقت يشمل نجاح حملية الحقل وانقسام البويضة المخصبة
+
+29
+00:02:26,170 --> 00:02:30,190
+في المختبر هذه نسبة نجاح معينة تعتبر theoretical
+
+30
+00:02:30,190 --> 00:02:35,790
+إلى حد ما ولكن النجاح الحقيقي هو عبارة عن إرجاع
+
+31
+00:02:35,790 --> 00:02:39,950
+البويضة المخصبة إلى رحم الأنثى ثم عمل implantation
+
+32
+00:02:39,950 --> 00:02:44,990
+وتكوين جنين ثم بعد نهاية 9 شهور الحصول على طفل
+
+33
+00:02:44,990 --> 00:02:49,770
+حقيقي على قيد الحياةكدا بتكون عملية الحقن المجهري
+
+34
+00:02:49,770 --> 00:02:55,290
+عملية ناجحة و بقدر أحقق نسبة و أحسب نسبة نجاح كل
+
+35
+00:02:55,290 --> 00:03:02,470
+ألف حالة جديش بحصل على theoretical إجزي true
+
+36
+00:03:02,470 --> 00:03:07,510
+process success process و جديش بحصل على success
+
+37
+00:03:07,510 --> 00:03:15,210
+process من ال إجزي plasma injection كعملية ناجحة
+
+38
+00:03:15,210 --> 00:03:18,480
+فبالتالي في عندينجاح حقيقي بالحصول على true pp
+
+39
+00:03:18,480 --> 00:03:23,200
+ونجاح إلى حد ما نظري مؤقت بنجاح حملية الحقن
+
+40
+00:03:23,200 --> 00:03:27,160
+المجهري من خلال القسام البويضة المخصبة في المختبر
+
+41
+00:03:27,160 --> 00:03:31,600
+فبالتالي إلى حد ما معدل الـdegenerated of oocyte
+
+42
+00:03:31,600 --> 00:03:38,460
+بعد الإجزي بتروح ما بين 1 إلى 2، 3، أقل من 3 يعني
+
+43
+00:03:38,460 --> 00:03:43,340
+1 إلى 3 كحد أعلى ان في عندي من كل .. من 100 طبعا
+
+44
+00:03:43,340 --> 00:03:48,270
+.. في عندي من كلميت بويضة مخصبة بيصير failure إلها
+
+45
+00:03:48,270 --> 00:03:51,910
+وما بتكمل عملية انقسام وهذا بنسميه Oocyte
+
+46
+00:03:51,910 --> 00:03:57,350
+Degradation after Exit طبعا ال Exit Failure كان بي
+
+47
+00:03:57,350 --> 00:04:02,150
+occur in three different level أول level ممكن يحدث
+
+48
+00:04:02,150 --> 00:04:05,570
+فيه failure لل Exit Process هو عبارة عن مرحلة
+
+49
+00:04:05,570 --> 00:04:09,550
+الحصول على ال spermatozoonوخاصة إذا كان ال male
+
+50
+00:04:09,550 --> 00:04:13,110
+يعاني من obstructive azospermia عنده obstructive
+
+51
+00:04:13,110 --> 00:04:16,990
+azospermia مش هيقدر يجيب عينة مافي عنده
+
+52
+00:04:16,990 --> 00:04:20,830
+ejaculation فهيضطر الطبيب يعمل testicular biopsy
+
+53
+00:04:20,830 --> 00:04:24,510
+اللي سمناها TSA أو PSA تصور إن الطبيب عمل
+
+54
+00:04:24,510 --> 00:04:29,030
+testicular biopsy ومالاجعش فيه عندي أو عند هذا ال
+
+55
+00:04:29,030 --> 00:04:32,850
+male أو عند هذه الحالة وانا بشغل مافي عندي
+
+56
+00:04:32,850 --> 00:04:36,630
+spermatozoaما في Anti-Spermatozoa هيه اللي جاء إلى
+
+57
+00:04:36,630 --> 00:04:41,910
+عمل cancellation أو cancel للـXE process فبالتالي
+
+58
+00:04:41,910 --> 00:04:46,710
+فشلت عملية الحقن المجهري بسبب عدم القدرة على حصول
+
+59
+00:04:46,710 --> 00:04:51,210
+على عين Anti-Spermatozoa من هذا الشخص المصاب بالـ
+
+60
+00:04:51,210 --> 00:04:55,290
+Obstructive AzospermiaOn the other hand, as may be
+
+61
+00:04:55,290 --> 00:05:00,010
+expected, sperm are recovered in virtually all
+
+62
+00:05:00,010 --> 00:05:03,090
+attempts involved man with obstructive aspermia
+
+63
+00:05:03,090 --> 00:05:05,370
+لأن الوضع الطبيعي بيقولك طالما عنده obstructive
+
+64
+00:05:05,370 --> 00:05:09,450
+aspermia، إيه المفروض؟من المصنع وهو ال testis
+
+65
+00:05:09,450 --> 00:05:12,530
+تشتغل بشكل طبيعي يعني لو أنا أعملت له testicular
+
+66
+00:05:12,530 --> 00:05:17,070
+biopsy المفروض ألاجه أن يكون عنده spermatozoa أصور
+
+67
+00:05:17,070 --> 00:05:21,050
+أن هذا الطبيب عمل testicular biopsy وما وجد وما
+
+68
+00:05:21,050 --> 00:05:23,910
+وجد عند هذا المريض أي نوع من أنواع ال spermatozoa
+
+69
+00:05:23,910 --> 00:05:27,330
+فبالتالي فشلت عملية الحقن المجهري إذن هذه أول
+
+70
+00:05:27,330 --> 00:05:31,550
+مرحلة من مراحل فشل الحقن المجهري التي يمكن أن تحدث
+
+71
+00:05:31,550 --> 00:05:35,700
+المرحلة التانيةfailure of fertilized after exit في
+
+72
+00:05:35,700 --> 00:05:40,260
+عندك كمية كافية من ال spermatozoa ال spermatozoa
+
+73
+00:05:40,260 --> 00:05:43,280
+morphological normal ولكن functional أنا لا أدري
+
+74
+00:05:43,280 --> 00:05:47,380
+فبالتالي حصلت على ال spermatozoa ولكن هذه ال
+
+75
+00:05:47,380 --> 00:05:52,200
+spermatozoa فشلت في إتمام عملية التلقيح خدوا بالكم
+
+76
+00:05:52,200 --> 00:05:56,140
+النقطة المهمة التلقيح بالمستوى و بالمعروف المبدأي
+
+77
+00:05:56,140 --> 00:06:00,080
+هو اختراق ال spermatozoa للبوايدة ولكن لكي أكتمل
+
+78
+00:06:00,080 --> 00:06:04,070
+التلقيح و أحكي أن في عنديtrue fertilization لازم
+
+79
+00:06:04,070 --> 00:06:06,630
+يصير اندماج ما بين النواء الذكرية مع النواء
+
+80
+00:06:06,630 --> 00:06:10,130
+الأنثوية فبالتالي بصير أقدر أقول أنه صار عندي
+
+81
+00:06:10,130 --> 00:06:14,490
+fertilization success process not failure of
+
+82
+00:06:14,490 --> 00:06:17,970
+fertilization مافي عندي فشل في ال fertilization ..
+
+83
+00:06:17,970 --> 00:06:20,570
+في ال fertilization ولكن ال fertilization نجحت
+
+84
+00:06:20,570 --> 00:06:23,710
+بشكل كامل the reasons for this few failures
+
+85
+00:06:23,710 --> 00:06:27,730
+remained unclear until now but we can summarize
+
+86
+00:06:27,730 --> 00:06:34,140
+this topic in differentLiver for example بور sperm
+
+87
+00:06:34,140 --> 00:06:39,000
+viability or a problem in the penetration of
+
+88
+00:06:39,000 --> 00:06:46,520
+oocyte ممكن انا يكون عندي مشكلة في عملية ال
+
+89
+00:06:46,520 --> 00:06:49,200
+viability بتاعة ال sperm metazoa فبالتالي كل sperm
+
+90
+00:06:49,200 --> 00:06:53,160
+dead morphological okay طبيعي 100% ولكن not life
+
+91
+00:06:53,160 --> 00:06:57,220
+فبالتالي هتفشل عملية ال fertilization ال sperm
+
+92
+00:06:57,220 --> 00:07:01,990
+metazoa lifeولكن ال oocyte مش mature فبالتالي
+
+93
+00:07:01,990 --> 00:07:06,610
+هتفشل عملية ال fertilization
+
+94
+00:07:06,610 --> 00:07:10,930
+نجحت عملية الاختراق ولكن لم تنجح عملية الدمش بين
+
+95
+00:07:10,930 --> 00:07:15,220
+النويتين فبالتالي فشلت عملية ال fertilizationفي
+
+96
+00:07:15,220 --> 00:07:18,400
+بعض الأحيان بعض الذكور في عندهم مشكلة بيسميها
+
+97
+00:07:18,400 --> 00:07:23,080
+Acrosomalis و ال Acrosomalis بمصطلح آخر بيسموه
+
+98
+00:07:23,080 --> 00:07:27,260
+Global Zospermic Global Zospermic Spermatozoa
+
+99
+00:07:27,260 --> 00:07:32,000
+cannot be achieved Sangam Sangam even after
+
+100
+00:07:32,000 --> 00:07:35,200
+existence شو يعني Sangam؟ Sangam معناه اندماج يعني
+
+101
+00:07:35,200 --> 00:07:39,020
+okay هذا الذكر عنده spermatozoa spermatozoa طبيعية
+
+102
+00:07:39,020 --> 00:07:42,780
+morphological functional مافي عنده أي مشكلة ولكن
+
+103
+00:07:42,780 --> 00:07:48,130
+هذه ال spermatozoaوهذه النطف لا تستطيع أن تصل إلى
+
+104
+00:07:48,130 --> 00:07:51,850
+المرحلة المطلوبة وهي الاندماج الكامل مع نوات
+
+105
+00:07:51,850 --> 00:07:55,270
+البويضة من أجل الحصول على ما يُرى باسم الزيجوت
+
+106
+00:07:55,270 --> 00:07:59,070
+فبالتالي فشلت عملية ال fertilization The sperm
+
+107
+00:07:59,070 --> 00:08:03,590
+cell of male with Globus ospermia however have a
+
+108
+00:08:03,590 --> 00:08:07,030
+round head and no acrosome عنده round head طبيعي
+
+109
+00:08:07,030 --> 00:08:11,090
+ولكن ال acrosome مش موجود المسؤول عنهإفراز
+
+110
+00:08:11,090 --> 00:08:14,090
+الإنزيمات المهمة لعملية ال penetration والمهمة
+
+111
+00:08:14,090 --> 00:08:18,010
+لعملية ال complete fusion the abnormal sperm are
+
+112
+00:08:18,010 --> 00:08:21,870
+unable to fertilize an egg and led to infertility
+
+113
+00:08:21,870 --> 00:08:25,390
+هذا بالوضع الطبيعي ولكن حكينا أن عملية ال
+
+114
+00:08:25,390 --> 00:08:29,140
+penetration تغلبت عليها بال eggsولكن في أمور تانية
+
+115
+00:08:29,140 --> 00:08:33,000
+الإجزي ما بقدر أو ما بستطيع أن يتغلب عليها وهي
+
+116
+00:08:33,000 --> 00:08:36,280
+الاندماج الكامل however, the successful
+
+117
+00:08:36,280 --> 00:08:39,200
+fertilization, pregnancy and overspring have
+
+118
+00:08:39,200 --> 00:08:44,120
+result after treat the oocyte post-egzi by either
+
+119
+00:08:44,120 --> 00:08:47,980
+chemical agent or electrical pulse what's the
+
+120
+00:08:47,980 --> 00:08:50,860
+meaning of this statement؟ بيقولك في الأولى
+
+121
+00:08:50,860 --> 00:08:55,220
+الأخيرة تم التخلص والتغلب علىعدم القدرة على
+
+122
+00:08:55,220 --> 00:08:59,860
+الاندماج بين النواتين من خلال حقن لـ spermatozoa
+
+123
+00:08:59,860 --> 00:09:03,880
+في منطقة بعيدة عن النواء الأنثوية الموجودة داخل
+
+124
+00:09:03,880 --> 00:09:08,320
+البويضة ثم معالجة هذه العملية بتعريض البويضة بعد
+
+125
+00:09:08,320 --> 00:09:14,160
+عملية الحقن إلى تيار كهربائي بفرق جهد معين ومنطقي
+
+126
+00:09:14,160 --> 00:09:18,000
+وقليل إلى حد ما أو إضافة بعض المواد الكيميائية
+
+127
+00:09:18,000 --> 00:09:23,070
+التي تسهل وتحفظ عملية ال fusionمما يؤدي إلى تكوين
+
+128
+00:09:23,070 --> 00:09:27,370
+الـ Zygote فبالتالي تغلبنا على مشكلة الاندماج
+
+129
+00:09:27,370 --> 00:09:30,970
+المرحلة التالتة أو ال level التالت من المستويات
+
+130
+00:09:30,970 --> 00:09:35,090
+التي يفشل فيها عملية الحقن المجهري تسمى failure to
+
+131
+00:09:35,090 --> 00:09:38,490
+cleavage after eggs fertilization تمام التمام ما
+
+132
+00:09:38,490 --> 00:09:42,110
+فيه عنده مشكلة فيه عنده نطف أنثوية و ذكيرية النطف
+
+133
+00:09:42,110 --> 00:09:44,650
+الذكيرية مافيش فيها مشكلة من حيث العدد و ال
+
+134
+00:09:44,650 --> 00:09:48,900
+morphology و ال functionalحصلت على immobilized
+
+135
+00:09:48,900 --> 00:09:53,760
+sperm of life عملتله insertion انحقا و اتغلبت على
+
+136
+00:09:53,760 --> 00:09:57,340
+مشكلة ال fusion باستعريضها إلى electrical field
+
+137
+00:09:57,340 --> 00:10:01,590
+بفرق جوده منخفض صار في عندي اندماجولكن البويضة
+
+138
+00:10:01,590 --> 00:10:05,490
+المندمجة الملقحة اللتي أصبحت مندمجة مع النواية
+
+139
+00:10:05,490 --> 00:10:09,930
+الذكرية لن تستطيع الاستمرار في الانقسام okay
+
+140
+00:10:09,930 --> 00:10:13,990
+انقسمت صارت عندى خليتين صارت عندى أربعة بعد كده
+
+141
+00:10:13,990 --> 00:10:19,830
+توقفت لم تكمل عملية الانقسام للوصول إلى ال 32 و64
+
+142
+00:10:19,830 --> 00:10:24,710
+خلية هذا بنسميها failure of cleavage يعني الخلل في
+
+143
+00:10:24,710 --> 00:10:28,610
+الانقسام او الفشل في الانقسام فبالتالي ما بستطيع
+
+144
+00:10:28,610 --> 00:10:34,090
+اقول عنها imperialوين رجعت لرحم السيدة بيكون فرصة
+
+145
+00:10:34,090 --> 00:10:38,270
+الفشل عالية جدا when the couple with filled with
+
+146
+00:10:38,270 --> 00:10:41,750
+filled eggs fertilization attempt future eggs
+
+147
+00:10:41,750 --> 00:10:44,990
+cycle their success rate were similar to other
+
+148
+00:10:44,990 --> 00:10:48,430
+couples undergoing repeating eggs cycle معنى
+
+149
+00:10:48,430 --> 00:10:52,080
+الكلام؟إن لو أنا عندي two couples عملوا إجزي cycle
+
+150
+00:10:52,080 --> 00:10:56,640
+وفشلت هيعملوا إجزي cycle جديدة مش معناها إن فشلت
+
+151
+00:10:56,640 --> 00:11:00,100
+هتنجح التانية ومش معناها إن نسبة الفشل هتكون
+
+152
+00:11:00,100 --> 00:11:04,660
+متتابعة يعني طالما فشلت الأولى لازم تفشل التانية و
+
+153
+00:11:04,660 --> 00:11:07,520
+التالتة و الرابعة طالما فشلت الأولى التانية لازم
+
+154
+00:11:07,520 --> 00:11:12,220
+تنجح لأ كل cycle لها chance بتسميه independent
+
+155
+00:11:12,220 --> 00:11:15,740
+event or independent chance لا تعتمد على الذي
+
+156
+00:11:15,740 --> 00:11:20,200
+يسبقها ولا تعتمد على الذي يليهافبالتالي ممكن تفشل
+
+157
+00:11:20,200 --> 00:11:24,960
+و ممكن تنجح the main problem that led to IGZ
+
+158
+00:11:24,960 --> 00:11:28,440
+failure أول حاجة spermatozoa remained attached to
+
+159
+00:11:28,440 --> 00:11:31,880
+the IGZ pipet while beginning release طبعا هنتكلم
+
+160
+00:11:31,880 --> 00:11:35,300
+عن الأسباب التي تؤدي إلى فشل IGZ ولكن من ناحية
+
+161
+00:11:35,300 --> 00:11:39,800
+practical من ناحية practical أول حاجة أنه أنا و
+
+162
+00:11:39,800 --> 00:11:43,120
+أنا بشغل ماقدرت أعمل releasing لل spermatozoa داخل
+
+163
+00:11:43,120 --> 00:11:48,130
+الvoider لسبب التصاقالـ spermatozoa في الصفح
+
+164
+00:11:48,130 --> 00:11:53,050
+الداخلي لل injection needle جد ما أضغط عشان أنزل و
+
+165
+00:11:53,050 --> 00:11:57,370
+أعمل releasing لل spermatozoa من ال injection
+
+166
+00:11:57,370 --> 00:12:02,090
+needle لأ مافي إمكانية لنصل إتصاب حاد و قوي ما بين
+
+167
+00:12:02,090 --> 00:12:04,270
+الجدار الداخلي لل injection needle و ال
+
+168
+00:12:04,270 --> 00:12:08,370
+spermatozoa insufficient immobilization of
+
+169
+00:12:08,370 --> 00:12:12,190
+spermatozoa as assessed by subsequent movement
+
+170
+00:12:12,190 --> 00:12:16,110
+بمعنى آخرإن ماعند الكمية الكافية من ال spermatozoa
+
+171
+00:12:16,110 --> 00:12:19,550
+اللي عملت لها immobilization كمية ال spermatozoa
+
+172
+00:12:19,550 --> 00:12:23,550
+أو عددها اللازمة الحقن لا يتماشى مع الكمية
+
+173
+00:12:23,550 --> 00:12:26,990
+المتوفرة يعني أنا عند خمس بويضات ماعملت
+
+174
+00:12:26,990 --> 00:12:30,130
+immobilization إلا لـ two spermatozoa لأن هم
+
+175
+00:12:30,130 --> 00:12:34,460
+المتوفرين فقطفبالتالي سيؤدي إلى فشل جزءي لعملية
+
+176
+00:12:34,460 --> 00:12:37,420
+الحقل المجهد Rejection of spermatozoa into
+
+177
+00:12:37,420 --> 00:12:42,320
+preventive space after exit إن الـ space بعد زولة
+
+178
+00:12:42,320 --> 00:12:46,150
+بلوسيدا الموجود في الـ oocyte عمل rejection لـالـ
+
+179
+00:12:46,150 --> 00:12:48,850
+spermatozoa فبالتالي فشلت شو يعني عمل rejection؟
+
+180
+00:12:48,850 --> 00:12:52,270
+يعني ماقدر يتقطبل دخول ال spermatozoa منع ال
+
+181
+00:12:52,270 --> 00:12:56,150
+spermatozoa انه يدخل طرد ال spermatozoa من الخلية
+
+182
+00:12:56,150 --> 00:12:59,790
+ككل هذه الحالات تتصير فلاجد حالات نادرة إلها
+
+183
+00:12:59,790 --> 00:13:04,670
+أسبابها المعينة difficult breaking of ulma أنا عند
+
+184
+00:13:04,670 --> 00:13:08,470
+injection needle هي اللي هتخترق الـ zoonablus ده
+
+185
+00:13:08,470 --> 00:13:12,050
+وتخترق و تدخل في ال cytoplasm صار في عند صعوبة
+
+186
+00:13:12,050 --> 00:13:15,630
+ماقدرت ال needleبتختارق لأن عملية الاختلاق لازم
+
+187
+00:13:15,630 --> 00:13:20,470
+تكون smooth و soft لإن لو زدت الضغط ممكن أعمل
+
+188
+00:13:20,470 --> 00:13:23,750
+rapture لل oocyte شو اللي بيخلي عندي مشكلة في
+
+189
+00:13:23,750 --> 00:13:26,190
+عملية اختراق الذنب اليوسيط أو القلمة أو ال
+
+190
+00:13:26,190 --> 00:13:30,770
+cytoplasmic of oocyte في وجود rigidity وجود صلابة
+
+191
+00:13:30,770 --> 00:13:36,080
+إلى حد ما فيمكونات الـ oocyte أو في مكونات الـ
+
+192
+00:13:36,080 --> 00:13:40,120
+zoonableucida فبالتالي ما بدي أغامل و أضغط
+
+193
+00:13:40,120 --> 00:13:45,810
+بالزيادة عشان ما أخسر البوايدة to overcomeهذا
+
+194
+00:13:45,810 --> 00:13:49,950
+الفرصة السعيدة للتنقل من أوسايت الـ Oocyte و الـ
+
+195
+00:13:49,950 --> 00:13:54,350
+alternative laser assist XE لقد تم تفضيلها مؤخراً
+
+196
+00:13:54,350 --> 00:13:59,090
+و تم تطبيقها بشركة patient بمشكلة مثل هذه المشكلة
+
+197
+00:13:59,090 --> 00:14:03,010
+ممكن أن اتغلب على ال rigidity ممكن أن اتغلب على
+
+198
+00:14:03,010 --> 00:14:06,910
+عدم استقبال ال space بعد زيورة الفلوسيدال ال
+
+199
+00:14:06,910 --> 00:14:10,850
+spermatozoa من خلال حاجة و تقنيك مهم جدا بتسموه
+
+200
+00:14:10,850 --> 00:14:14,460
+laser assist hatching أو laser hatchingإيش فكرة
+
+201
+00:14:14,460 --> 00:14:17,120
+الـ Laser Hatching؟ إنه عندي أنا مدفع إلى حد ما
+
+202
+00:14:17,120 --> 00:14:21,160
+بيسموه مدفع الـ Laser أو مطلق الـ Laser بطلق نبضات
+
+203
+00:14:21,160 --> 00:14:23,620
+من الـ Laser على منطقة معينة موجودة في الزورة
+
+204
+00:14:23,620 --> 00:14:29,240
+بليوسيدا علشان يعملها عملية ثقوف داخلها فبالتالي
+
+205
+00:14:29,240 --> 00:14:33,860
+بسمح بدخول ال injection needle بسهولة خصوصا إذا
+
+206
+00:14:33,860 --> 00:14:37,000
+كان في عندي نوع من أنواع الصلابة و الصعوبة في
+
+207
+00:14:37,000 --> 00:14:40,940
+اختراق الزورة بليوسيدا من خلال ال injection needle
+
+208
+00:14:40,940 --> 00:14:47,160
+زي ما أحنا شايفين هناهي الـ Oocyte الـ Oocyte أجى
+
+209
+00:14:47,160 --> 00:14:51,880
+مدفع الليزر، ضرط طلقة هنا، فعملت فجوة بمقدار 5 إلى
+
+210
+00:14:51,880 --> 00:14:57,760
+10 ميكروميتر في الزنا بليوسيدا هذه الفجوة تسمح للـ
+
+211
+00:14:57,760 --> 00:15:03,080
+injection needle بالدخول ببساطة وبسهولة للوصول إلى
+
+212
+00:15:03,080 --> 00:15:07,380
+أقرب منطقة من الـcytoplasmالفجوة اللي بتصير
+
+213
+00:15:07,380 --> 00:15:10,320
+مابتكون كاملة عشان مايصيرش leakage لمحتوى
+
+214
+00:15:10,320 --> 00:15:13,400
+الـcytoplasm لأن هذا النقطة البسيطة اللتي أصبحت
+
+215
+00:15:13,400 --> 00:15:17,660
+تمنع ال leakage يجب اختراقها باستخدام ال injection
+
+216
+00:15:17,660 --> 00:15:21,280
+needed إيش هذا اسم التكنيك؟ اسمه Laser Hatching
+
+217
+00:15:21,280 --> 00:15:27,320
+وحنتكلم عنه بشكل موسع في عملية ال embryo biopsy في
+
+218
+00:15:27,320 --> 00:15:30,520
+ال chapter اللي قادم ان شاء الله خليني أشوف
+
+219
+00:15:30,520 --> 00:15:34,640
+الفيديو هذاكيف و بيتكلم و بحكي عن عملية الـ Laser
+
+220
+00:15:34,640 --> 00:15:41,420
+Hatch So
+
+221
+00:15:41,420 --> 00:15:43,560
+this is Deborah preparing one of our ICSI dishes
+
+222
+00:15:43,560 --> 00:15:46,620
+which actually are once again prepared sterile
+
+223
+00:15:46,620 --> 00:15:52,280
+with certified and tested medias what she's doing
+
+224
+00:15:52,280 --> 00:15:57,780
+initially here is getting out the PVP or the first
+
+225
+00:15:57,780 --> 00:16:01,970
+media that we need in order to have the spermلذلك
+
+226
+00:16:01,970 --> 00:16:05,290
+يبطئهم قليلاً لكي نستطيع أن نجربهم في البداية
+
+227
+00:16:05,290 --> 00:16:10,170
+تستخدم ميديا ميكرو درس ميكرو درس ميكرو درس ميكرو
+
+228
+00:16:10,170 --> 00:16:10,310
+درس ميكرو درس ميكرو درس ميكرو درس ميكرو درس ميكرو
+
+229
+00:16:10,310 --> 00:16:12,370
+درس ميكرو درس ميكرو درس ميكرو درس ميكرو درس ميكرو
+
+230
+00:16:12,370 --> 00:16:12,550
+درس ميكرو درس ميكرو درس ميكرو درس ميكرو درس ميكرو
+
+231
+00:16:12,550 --> 00:16:12,650
+درس ميكرو درس ميكرو درس ميكرو درس ميكرو درس ميكرو
+
+232
+00:16:12,650 --> 00:16:26,850
+درس ميكرو درس ميكرو
+
+233
+00:16:26,850 --> 00:16:33,740
+درس ميكرو درFinding the media that we need in
+
+234
+00:16:33,740 --> 00:16:36,380
+order to do this, this micro manipulation media,
+
+235
+00:16:36,500 --> 00:16:38,720
+she's going to make multiple drops here, so we'd
+
+236
+00:16:38,720 --> 00:16:43,070
+be able to do more than one egg at a timeطبعا هنا
+
+237
+00:16:43,070 --> 00:16:46,210
+هي بتعمل preparation for exe dish وضعت القطرة
+
+238
+00:16:46,210 --> 00:16:50,250
+الأولى وهي ال PVP media المسئولة عن تحميل الجميطات
+
+239
+00:16:50,250 --> 00:16:54,210
+الذكرية فيها ثم وضعت ال media الخاصة بال oocyte
+
+240
+00:16:54,210 --> 00:16:57,530
+بشرط يقولنا 8 قطرات في كل قطرة بوايدة أو بوايدتين
+
+241
+00:16:57,530 --> 00:17:01,230
+للناس المبتدئة although it's only one patient at a
+
+242
+00:17:01,230 --> 00:17:07,060
+time and we never reuse a dishالعزيزة قمت بإنهاء
+
+243
+00:17:07,060 --> 00:17:10,200
+الأسلحة الأولى والعزيزة ستقوم بتغطية الزبدة التي
+
+244
+00:17:10,200 --> 00:17:15,520
+ستكون محمية حماية لكي لا تتفرد و لكي تبقى مرموزا
+
+245
+00:17:15,520 --> 00:17:21,620
+مرموزا مرموزا مرموزا مرموزا مرموزا
+
+246
+00:17:21,620 --> 00:17:22,500
+مرموزا
+
+247
+00:17:47,840 --> 00:17:51,040
+طبعا هنا هيبدأ عملية الـ injection بالتعرف على
+
+248
+00:17:51,040 --> 00:17:53,840
+الميكروسكوب بالإضافة إلى التحدث عن الـ injection
+
+249
+00:17:53,840 --> 00:17:58,980
+needle و الـholder tubeهيبدأ بتركيب الـ holder
+
+250
+00:17:58,980 --> 00:18:02,500
+tube ثم تركيب ال injection needle وعمليات ال إكسي
+
+251
+00:18:02,500 --> 00:18:05,620
+put it on a micro tool holder and on the left hand
+
+252
+00:18:05,620 --> 00:18:09,600
+side here we will put it up and in place there you
+
+253
+00:18:09,600 --> 00:18:12,820
+see a nice clean holding pipette about 120 microns
+
+254
+00:18:12,820 --> 00:18:16,140
+in size about what will be the same size of the
+
+255
+00:18:16,140 --> 00:18:18,660
+eggs that we'll be using now over on this side I
+
+256
+00:18:18,660 --> 00:18:20,780
+have to put the iksi needle now this needle is
+
+257
+00:18:20,780 --> 00:18:25,780
+very very small it's aboutEight microns in size.
+
+258
+00:18:26,200 --> 00:18:30,020
+You can fit at the end of this one hundred of
+
+259
+00:18:30,020 --> 00:18:33,040
+these in the thickness of one hair. So once again
+
+260
+00:18:33,040 --> 00:18:35,060
+I get everything prepared, get it up and into
+
+261
+00:18:35,060 --> 00:18:37,680
+place, and then go through the process of
+
+262
+00:18:37,680 --> 00:18:41,060
+alignment to get everything set ahead of time.So
+
+263
+00:18:41,060 --> 00:18:43,800
+we're getting prepared to do an ICSI here. So we
+
+264
+00:18:43,800 --> 00:18:45,660
+need to label up the dish once again with a
+
+265
+00:18:45,660 --> 00:18:47,940
+diamond pen with the name of the patient who we're
+
+266
+00:18:47,940 --> 00:18:51,060
+going to do so that we know what it is.Then we
+
+267
+00:18:51,060 --> 00:18:53,940
+have a second person come and check that the sperm
+
+268
+00:18:53,940 --> 00:18:56,600
+matches up to the paperwork for this specific
+
+269
+00:18:56,600 --> 00:18:59,380
+patient and I have to verify and then additionally
+
+270
+00:18:59,380 --> 00:19:03,780
+that the individual eggs match up with the patient
+
+271
+00:19:03,780 --> 00:19:07,010
+specific information.فانتظرين 2 شخص واحد دائما قبل
+
+272
+00:19:07,010 --> 00:19:08,990
+أن يكون اي شيء مفهوم و نقوم بمزيد من البيضاء و
+
+273
+00:19:08,990 --> 00:19:12,870
+النار ففي هذه الحالة انا واضح انها شهدت كل ما
+
+274
+00:19:12,870 --> 00:19:14,970
+احتاجه لذلك انا قمت بتعامل عبارة عن عبارة عن عبارة
+
+275
+00:19:14,970 --> 00:19:18,750
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+276
+00:19:18,750 --> 00:19:18,930
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+277
+00:19:18,930 --> 00:19:19,510
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+278
+00:19:19,510 --> 00:19:19,710
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+279
+00:19:19,710 --> 00:19:33,470
+عن عبارة عن عبارة عن عبارة عن عبار
+
+280
+00:19:34,800 --> 00:19:37,520
+Now I will go ahead and grab the eggs that I need
+
+281
+00:19:37,520 --> 00:19:44,360
+and I'll move them to the EGGSY DISH طبعا هنا بدأ
+
+282
+00:19:44,360 --> 00:19:48,520
+بتحميل ال spermatozoa as a male gamete على قطرة ال
+
+283
+00:19:48,520 --> 00:19:52,300
+PVV بعدين هياخد ال oocyte من الطبق الخاص فيه
+
+284
+00:19:52,300 --> 00:19:55,940
+وينقلهم على الطبق الخاص بال EGGSY DISH تمهيدا
+
+285
+00:19:55,940 --> 00:19:56,780
+لعملية الحقنة
+
+286
+00:20:06,560 --> 00:20:08,980
+So I'll put them away temporarily in the micro
+
+287
+00:20:08,980 --> 00:20:11,280
+chamber which is getting humidity and gas levels
+
+288
+00:20:11,280 --> 00:20:14,040
+at the appropriate thing Now my eggs and sperm are
+
+289
+00:20:14,040 --> 00:20:16,100
+both in the same dish and we're going to go and
+
+290
+00:20:16,100 --> 00:20:20,080
+actually perform the ICSI procedureلذلك إذا كنت
+
+291
+00:20:20,080 --> 00:20:22,960
+تنظر كما أفعل هذا على الشاشة الآن ترى مجموعة من
+
+292
+00:20:22,960 --> 00:20:26,480
+الأشياء الصغيرة المتحركة هؤلاء هم الصحراء سأقوم
+
+293
+00:20:26,480 --> 00:20:32,560
+بإزالة واحدة منهم في جزء من إكسي نيدلي طبعا هنا في
+
+294
+00:20:32,560 --> 00:20:35,580
+البداية هيدخل على ال media PVP عشان يبدأ يعمل
+
+295
+00:20:35,580 --> 00:20:39,460
+immobilization للصحراء الذواء وينقل عدد منهم إلى
+
+296
+00:20:39,460 --> 00:20:43,400
+الداخل ال injection needle من أجل تمهيدة عملية ال
+
+297
+00:20:43,400 --> 00:20:47,580
+injection in order to then inject them into the
+
+298
+00:20:47,580 --> 00:20:48,520
+mature eggs
+
+299
+00:20:51,700 --> 00:20:53,720
+So initially I'm bringing down my Yixin needle
+
+300
+00:20:53,720 --> 00:20:57,840
+which you can see now on the screen and I'm going
+
+301
+00:20:57,840 --> 00:21:01,100
+to go in and find a few very normal looking sperm
+
+302
+00:21:01,100 --> 00:21:04,340
+and
+
+303
+00:21:04,340 --> 00:21:09,840
+I'm going to immobilize them by
+
+304
+00:21:09,840 --> 00:21:13,780
+very carefully but strongly rubbing them against
+
+305
+00:21:13,780 --> 00:21:18,760
+the bottom of the dish in order toلتحركهم و
+
+306
+00:21:18,760 --> 00:21:23,200
+لتحركهم في التفكير بأنهم يدخلوا في البيض نفسه.
+
+307
+00:21:23,800 --> 00:21:27,840
+لذلك انا اقوم بتحريك واحد و اخرجه من البيبت و اقوم
+
+308
+00:21:27,840 --> 00:21:30,220
+بتحريكه من خلفه. لذلك الان انا اقوم بتحريك واحد
+
+309
+00:21:30,220 --> 00:21:34,320
+واحد من داخلي اللوح. إذا كنت تنظر جيدا سوف اريك ان
+
+310
+00:21:34,320 --> 00:21:38,040
+في نهاية اللوح من اللوح. انا اقوم بتحريك شخصية رأس
+
+311
+00:21:38,040 --> 00:21:43,600
+كبيرة في نهاية اللوح. لذلك في نهاية اللوح من
+
+312
+00:21:43,600 --> 00:21:45,260
+البيبت. انا اقوم بتحريك شخصية رأس كبيرة.
+
+313
+00:21:48,480 --> 00:21:54,620
+أدى عملية الحقن طبعا
+
+314
+00:21:54,620 --> 00:21:58,180
+هنا بيبدأ عملية الحقن اعمل عملية fix لل oocyte
+
+315
+00:21:58,180 --> 00:22:01,660
+باستخدام ال holder tube بشرط ان يكون ال body عند
+
+316
+00:22:01,660 --> 00:22:05,220
+الساعة 6 او عند الساعة 12 ويبدأ عملية ال injection
+
+317
+00:22:05,220 --> 00:22:09,480
+عند الساعة 3 بالظبط تخيل ان ال injection نيدل بكل
+
+318
+00:22:09,480 --> 00:22:13,470
+بساطة و بكل هدوء وبشكل smooth جداbrought the sperm
+
+319
+00:22:13,470 --> 00:22:16,230
+head right to the end of the needle and now I'm
+
+320
+00:22:16,230 --> 00:22:19,870
+pushing my way through the shell of the egg and
+
+321
+00:22:19,870 --> 00:22:22,410
+there it went and now I'm pushing my way through
+
+322
+00:22:22,410 --> 00:22:25,930
+the membrane of the egg and it broke now I'm going
+
+323
+00:22:25,930 --> 00:22:28,090
+to mix the sperm and the inside of the egg
+
+324
+00:22:28,090 --> 00:22:32,330
+together and I'm going to leave the eggI just
+
+325
+00:22:32,330 --> 00:22:35,250
+performed one single ICSI and deposited one single
+
+326
+00:22:35,250 --> 00:22:38,270
+sperm at the end.So to give you an idea you can
+
+327
+00:22:38,270 --> 00:22:40,490
+see the channel that I went in is directly along
+
+328
+00:22:40,490 --> 00:22:43,690
+here and at the very very end is the single sperm
+
+329
+00:22:43,690 --> 00:22:46,350
+head that was deposited there.So we've done one
+
+330
+00:22:46,350 --> 00:22:49,970
+roll that one away and let's bring up the next
+
+331
+00:22:49,970 --> 00:22:53,690
+candidate.I will align that much that polar body
+
+332
+00:22:53,690 --> 00:22:57,750
+for knowing where it's mature and now I will move
+
+333
+00:22:57,750 --> 00:23:02,470
+throughكدا تمت عملية حقن one o o site باستخدام
+
+334
+00:23:02,470 --> 00:23:07,350
+single sperm قرفنا على ال exe procedure من لحظة
+
+335
+00:23:07,350 --> 00:23:11,290
+تحضير ال exe dish حتى عملية الحقن بعد ما تم عملية
+
+336
+00:23:11,290 --> 00:23:15,610
+الحقن بتم عملية نقلهم إلى ال incubator في ظروف
+
+337
+00:23:15,610 --> 00:23:19,820
+معينة من أجل عمليةالـ Cleavage وهذا اللي هنتكلم
+
+338
+00:23:19,820 --> 00:23:23,460
+عليها فيما بعد Embryo evaluation from the zygote
+
+339
+00:23:23,460 --> 00:23:27,180
+to the blastocyst stage كيف يتم انقسام ال embryo
+
+340
+00:23:27,180 --> 00:23:31,280
+أو البويضة المخصبة للوصول إلى مرحلة ال zygote ثم
+
+341
+00:23:31,280 --> 00:23:34,200
+للوصول إلى مرحلة ال blastocyte أو ال blastocyst
+
+342
+00:23:34,200 --> 00:23:36,700
+بيسموها في بعض الأحيان أو في معظم الأحيان بيسموها
+
+343
+00:23:36,700 --> 00:23:42,460
+blastocyst لكي نحصل على embryo كامل ال
+
+344
+00:23:42,460 --> 00:23:45,780
+introduction ببساطة جدا بعد ال oocyte injection
+
+345
+00:23:46,140 --> 00:23:49,640
+There are moved to the culture dish prepared and
+
+346
+00:23:49,640 --> 00:23:56,370
+pre-incubated for more than 24 hours بمعنى آخرإن
+
+347
+00:23:56,370 --> 00:24:02,190
+البويضات اللي صارلها عملية
+
+348
+00:24:02,190 --> 00:24:05,390
+denodation
+
+349
+00:24:05,390 --> 00:24:09,910
+وهي إزالة الكيومال السل من عليها يجب أن تنقل إلى
+
+350
+00:24:09,910 --> 00:24:12,990
+طبق ال petri dish أو ال Exodus اللي شفناه قبل
+
+351
+00:24:12,990 --> 00:24:17,910
+بشوية و اللي لازم يكون محضر قبل من 6 إلى 12 ساعة
+
+352
+00:24:17,910 --> 00:24:23,170
+من عملية الحقن علشان ياخد ال atmosphericأو ياخد ال
+
+353
+00:24:23,170 --> 00:24:27,170
+fact أو ياخد المنظومة
+
+354
+00:24:27,170 --> 00:24:30,830
+المطلوبة اللي لازم تكون في ال incubator و يصير
+
+355
+00:24:30,830 --> 00:24:38,110
+عملية تكيف للطبقبعد كده باستخدام إبندروف إتيوب
+
+356
+00:24:38,110 --> 00:24:44,030
+بنعمل على نقل الـ oocyte اللي صارها عملية تعرية أو
+
+357
+00:24:44,030 --> 00:24:48,590
+عملية إزالة ال accumulus إلى ال drop media اللي
+
+358
+00:24:48,590 --> 00:24:53,590
+موجودة على الأطراف و اللي عددها تمانية و بناخد حجم
+
+359
+00:24:53,590 --> 00:24:56,930
+معين من ال spermatozoa و بنحطها في القطرة الموجودة
+
+360
+00:24:56,930 --> 00:25:01,750
+في المتصف اللي سمناها PVP media من أجل عملية ال M
+
+361
+00:25:01,750 --> 00:25:06,300
+-mobilization طبعا ال Exodusلازم يوضع فيه CO2
+
+362
+00:25:06,300 --> 00:25:11,980
+انكبياتور بيحتوي على 37 درجة مئوية 5% carbon
+
+363
+00:25:11,980 --> 00:25:17,180
+dioxide و 95% humidity ال fertilization check بعد
+
+364
+00:25:17,180 --> 00:25:20,460
+الإجزي لازم أعمل fertilization check لل OO site
+
+365
+00:25:20,460 --> 00:25:25,800
+بعد 16 إلى 18 ساعة من عملية ال insemination أو
+
+366
+00:25:25,800 --> 00:25:28,830
+عملية ال intracytoplasmic sperm injectionيعني
+
+367
+00:25:28,830 --> 00:25:31,950
+بمعنى أخر لو أنا عملت injection للبوايدة الساعة
+
+368
+00:25:31,950 --> 00:25:35,510
+ستة صباحا تاني يوم الساعة ستة صباحا لازم أبدأ أعمل
+
+369
+00:25:35,510 --> 00:25:39,590
+check-up تحت الميكروسكوب هل صار cleavage للبوايدة
+
+370
+00:25:39,590 --> 00:25:44,210
+المخصبة ولا لأ هذه مهم جدا أول مرحلة من مراحل
+
+371
+00:25:44,210 --> 00:25:48,510
+النجاح الإجزي وجود ما يُعرف باسم Lebron nuclei
+
+372
+00:25:48,510 --> 00:25:51,970
+Lebron nuclei هنتكلم عنها وشوهي Lebron nuclei
+
+373
+00:25:51,970 --> 00:25:58,450
+وشوهو إزاي God كيف يتم تحديدوعمل evaluation و
+
+374
+00:25:58,450 --> 00:26:01,330
+assessment لعملية ال fertilization واللي أنا من
+
+375
+00:26:01,330 --> 00:26:04,470
+خلالها بقول والله عملية ال fertilization نجحت أو
+
+376
+00:26:04,470 --> 00:26:07,310
+عملية ال fertilization فشلة morphological
+
+377
+00:26:07,310 --> 00:26:12,550
+assessment is evaluated on several days Thursday
+
+378
+00:26:12,550 --> 00:26:17,550
+0, 1, 2, 3 شو يعني Thursday 0؟ Thursday 0 يعني
+
+379
+00:26:17,550 --> 00:26:21,740
+اليوم اللي صار فيه عملية ال injection من خلالتقييم
+
+380
+00:26:21,740 --> 00:26:25,280
+البويضة، هل البويضة ناضجة أو غير ناضجة، من خلال
+
+381
+00:26:25,280 --> 00:26:28,160
+تقييم الـSpermatozoa، هل الـSpermatozoa صالحة
+
+382
+00:26:28,160 --> 00:26:31,380
+لعملية الحقن ولا لا، هذه بنسميها Fairest
+
+383
+00:26:31,380 --> 00:26:36,640
+Evaluation in the Zero Day أسيسمات في الـDay 5 و
+
+384
+00:26:36,640 --> 00:26:40,620
+Day 6 مرتبطة بـExtent Culture to the Plastocyst
+
+385
+00:26:40,620 --> 00:26:44,270
+Stageيعني أنا ممكن أعمل evaluation في اليوم رقم 0
+
+386
+00:26:44,270 --> 00:26:49,890
+و 1 و 2 و 3 و 4 و 5 و 6 اليوم رقم 0 أنا بتأكد منه
+
+387
+00:26:49,890 --> 00:26:53,970
+من الجامدات صالحة أم غير صالحة لعملية الحقناليوم
+
+388
+00:26:53,970 --> 00:26:58,690
+الـ 1 و 2 و 3 و 4 بتأكد من عملية الإنقسامات سليمة
+
+389
+00:26:58,690 --> 00:27:03,250
+ولا لأ خمسة و ستة بستخدمهم في بعض الأحيان إذا كان
+
+390
+00:27:03,250 --> 00:27:07,310
+في عند عملية زيادة في فترة ال incubation كان عملية
+
+391
+00:27:07,310 --> 00:27:10,830
+الإنقسام عملية غير متناسقة فبالتالي بدي أزيد فترة
+
+392
+00:27:10,830 --> 00:27:14,450
+ال incubation في ال incubator و أرجع بعد اليوم
+
+393
+00:27:14,450 --> 00:27:19,920
+الخامس علشان أضمن أنه العددالبلاستوست أو الجنين
+
+394
+00:27:19,920 --> 00:27:24,460
+وصل إلى level معين من المقسمات تسمح ليه بعمل عملية
+
+395
+00:27:24,460 --> 00:27:30,080
+إعادة لهذا الجنين طبعا في ال D0 evaluation تعتمد
+
+396
+00:27:30,080 --> 00:27:33,380
+على تقييم ال oocyte من حيث ال morphology هل ال
+
+397
+00:27:33,380 --> 00:27:36,460
+oocyte صالح العملية الحقن ولا لأ تقييم ال
+
+398
+00:27:36,460 --> 00:27:39,950
+spermatozoa من حيث العددمن حيث الـ morphology، من
+
+399
+00:27:39,950 --> 00:27:43,990
+حيث الـ functional وهذه العملية بتصير جامع العملية
+
+400
+00:27:43,990 --> 00:27:47,650
+الـ insemination prior to insemination أو إجزي
+
+401
+00:27:47,650 --> 00:27:51,750
+وبما فيهم العملية بيسميها oocyte denodation عملية
+
+402
+00:27:51,750 --> 00:27:55,530
+تعريط الـ oocyte طبعا ال immature oocyte لا تصلح
+
+403
+00:27:55,530 --> 00:27:59,630
+لعملية الحقن المجهري واللي سميناها إنها بتكون في
+
+404
+00:27:59,630 --> 00:28:05,570
+الـ GVأما الخلية والبوايدة التي تصلح لعملية الحقن
+
+405
+00:28:05,570 --> 00:28:08,930
+المجهري هي الخلية التي توقفت في القسم الميوزي
+
+406
+00:28:08,930 --> 00:28:12,190
+الثاني في مرحلة الـmetaphyse second metaphyse
+
+407
+00:28:12,190 --> 00:28:16,510
+واللي بتتميز بوجود fairest polar body، fairest
+
+408
+00:28:16,510 --> 00:28:19,810
+polar body، هذه بتكون صالحة لعملية ال
+
+409
+00:28:19,810 --> 00:28:23,110
+fertilizationخلصنا عملية ال evaluation للـ zero
+
+410
+00:28:23,110 --> 00:28:26,590
+day بنيجي لل evaluation لل first day ال first day
+
+411
+00:28:26,590 --> 00:28:30,090
+هي عبارة عن normal زيجوت formed on day one and
+
+412
+00:28:30,090 --> 00:28:33,150
+should have two pronuclear شو يعني الزيجوت؟
+
+413
+00:28:33,150 --> 00:28:35,530
+الواجهة أنا عندى فيه نواة ذكرية تأتي من ال sperm
+
+414
+00:28:35,530 --> 00:28:39,580
+متزوها و نواة أنثوية موجودة في البويضةعند الحقن
+
+415
+00:28:39,580 --> 00:28:43,220
+تندمج النواة الذكرية مع النواة الأنثوية فبيعطيني
+
+416
+00:28:43,220 --> 00:28:46,980
+نواة واحدة ولكن في بينهم انفصال بسيط جدا نسميه
+
+417
+00:28:46,980 --> 00:28:53,440
+pronuclei ال pronuclei يعني قبل النوية وسميتها 2PN
+
+418
+00:28:53,440 --> 00:28:57,300
+يعني 2 pronuclei لإن فيها نواة من ذكر و نواة من
+
+419
+00:28:57,300 --> 00:29:02,440
+أنثى عشان كده سمناهم 2PN و ال 2PN هي أول علامة من
+
+420
+00:29:02,440 --> 00:29:06,920
+علامات نجاح عملية الحقد المجهريلازم يقولوا اتنين
+
+421
+00:29:06,920 --> 00:29:10,920
+PN وهي ال two pronuclear هي عبارة عن equal في ال
+
+422
+00:29:10,920 --> 00:29:14,140
+size very close متقاربين من بعض ومن بعض وموجود في
+
+423
+00:29:14,140 --> 00:29:17,860
+ال center of cytoplasm مش على طرف البوايدة لأ في
+
+424
+00:29:17,860 --> 00:29:21,540
+منتصف البوايدة إذا المتمثلين في الحجم مقتربين من
+
+425
+00:29:21,540 --> 00:29:25,300
+بعض ومن بعض وفي منتصف الcytoplasm الخاص بالبوايدة
+
+426
+00:29:25,300 --> 00:29:28,680
+ال PN واللي سميتها pronuclear morphological should
+
+427
+00:29:28,680 --> 00:29:33,100
+be grade between60 to 80 hours post insemination
+
+428
+00:29:33,100 --> 00:29:37,680
+يعني متى بتظهر؟ بتظهر بعد 16 ساعة من عملية الإجزة
+
+429
+00:29:37,680 --> 00:29:40,780
+فإذا ظهرت بعد 16 ساعة من عملية الإجزة بقدر أقول
+
+430
+00:29:40,780 --> 00:29:45,260
+والله أن عملية الحق العملية سليمة وناجحة 100% ال M
+
+431
+00:29:45,260 --> 00:29:49,760
+phase is observed between 22 to 31 hour and a
+
+432
+00:29:49,760 --> 00:29:54,200
+cleavage to two cells stage taking place 25 to 33
+
+433
+00:29:54,200 --> 00:29:57,890
+hours post inseminationيعني بمعنى آخر أن البوايضة
+
+434
+00:29:57,890 --> 00:30:02,190
+الناضجة بعد عملية الإنقسام تأخذ لها لكي تنتقسم إلى
+
+435
+00:30:02,190 --> 00:30:05,630
+خليتين خدوا بالك فيه فرق بين ال two cells و ال two
+
+436
+00:30:05,630 --> 00:30:09,910
+PN ال two PN هي علاقة بالأنوية أما ال two cells
+
+437
+00:30:09,910 --> 00:30:16,470
+تأخذ لها من 25 ساعة إلى 4-33 ساعة بعد عملية الحقن
+
+438
+00:30:16,470 --> 00:30:22,170
+يعني تقريبا تقدر تقولبعد سبع ساعات من ظهور الـ
+
+439
+00:30:22,170 --> 00:30:26,330
+pronuclear تبدأ الخلية بالانقسام إلى خليتين لأن
+
+440
+00:30:26,330 --> 00:30:30,090
+بعد عملية ال insemination ب16 إلى 18 ساعة لازم
+
+441
+00:30:30,090 --> 00:30:35,750
+تكون ظهرت ال BN أو الـ 2BN 2 pronuclear بعد عملية
+
+442
+00:30:35,750 --> 00:30:41,910
+الحقن ب 225 ساعة تبدأ في ظهور عملية ال cleavage
+
+443
+00:30:41,910 --> 00:30:47,190
+للخلية لكي تصبح خليتين لكي تصبح خليتين طبعا ال BN
+
+444
+00:30:47,190 --> 00:30:50,540
+morphology is a very important stepwhen evaluating
+
+445
+00:30:50,540 --> 00:30:52,980
+morphology because it is the first point and the
+
+446
+00:30:52,980 --> 00:30:56,780
+first critical point to true and good grade of
+
+447
+00:30:56,780 --> 00:31:01,200
+embryo as I got embryo evaluation كيف انا بقدر
+
+448
+00:31:01,200 --> 00:31:04,080
+اقول والله هذه البوايضة نجحت في عملية الاخصاد
+
+449
+00:31:04,080 --> 00:31:10,500
+ونجحت في السير اتجاه الانقسام اول حاجة ظهور ال 2pm
+
+450
+00:31:10,500 --> 00:31:15,700
+بعد 16 ساعةتاني حاجة، ظهور الـ second polar body،
+
+451
+00:31:15,700 --> 00:31:19,280
+يعني صار في عندي 2PM بعد 16 أو 18 ساعة من عملية ال
+
+452
+00:31:19,280 --> 00:31:23,660
+injection تانياً، ظهر ال second polar body خارج
+
+453
+00:31:23,660 --> 00:31:26,900
+البوايدة، معناه صار اختزال لعدد الكرموزوات
+
+454
+00:31:26,900 --> 00:31:31,250
+الأنثويةإلى 23 كرموزوم لكي تندمج مع الـ 23 كرموزوم
+
+455
+00:31:31,250 --> 00:31:35,730
+اللي جاء من الأب فبصفح أندي 46 كرموزوم أو 23 زوج
+
+456
+00:31:35,730 --> 00:31:39,690
+من الكرموزوم الواحدة إذن the first critical point
+
+457
+00:31:39,690 --> 00:31:43,210
+ظهور الـ 2PN and the second critical point ظهور
+
+458
+00:31:43,210 --> 00:31:49,050
+الـ second polar body أي تأخر في ظهور الـ PN معناه
+
+459
+00:31:49,050 --> 00:31:53,170
+أنه بعد ال insemination أي تأخر بيكون مرتبط بعملية
+
+460
+00:31:53,170 --> 00:31:56,830
+تدهور في عملية development للإمبريوبيعطيني poor
+
+461
+00:31:56,830 --> 00:32:00,830
+embryo development بالإضافة إلى زيادة فرصة حدوث لـ
+
+462
+00:32:00,830 --> 00:32:04,150
+chromosomal abnormality و هذه مشكلة إنه والله
+
+463
+00:32:04,150 --> 00:32:08,070
+البيئة أنما زهرت بعد 18 ساعة زهرت بعد 25 ساعة
+
+464
+00:32:08,070 --> 00:32:11,890
+معناه في عندي مشكلة في ال chromosome تؤدي إلى
+
+465
+00:32:11,890 --> 00:32:15,690
+زيادة معدل حدوث لـ chromosomal abnormality هذه
+
+466
+00:32:15,690 --> 00:32:20,150
+نقطة والنقطة التانية قلنا اللي هي علاقة بال second
+
+467
+00:32:20,150 --> 00:32:23,510
+polar body طب في نقطة تالتة من خلالها بقدر أتحكم
+
+468
+00:32:23,510 --> 00:32:28,860
+وأحكمفي عملية نجاح عملية الإخصاب وهي عبارة عن ال
+
+469
+00:32:28,860 --> 00:32:31,920
+orientation شو يعني ال orientation؟ مقصود بال
+
+470
+00:32:31,920 --> 00:32:36,740
+orientation هي الالتفاف هل ال polar body و ال 2PN
+
+471
+00:32:36,740 --> 00:32:41,620
+في مسار واحد؟ هل في فضاء واحد ولا لأ؟ طيب ال polar
+
+472
+00:32:41,620 --> 00:32:46,460
+أو حاجة بنسميها ال pronuclear orientation is in
+
+473
+00:32:46,460 --> 00:32:49,620
+relationship to the polar body can also be used to
+
+474
+00:32:49,620 --> 00:32:53,490
+evaluate embryo morphology in day oneأول حاجة الـ
+
+475
+00:32:53,490 --> 00:32:58,160
+2 polar body ظهوره ثانية حاجة ظهور الـ 2PLتالت
+
+476
+00:32:58,160 --> 00:33:01,300
+حاجة ال orientation الموجودة ما بين ال pro nuclear
+
+477
+00:33:01,300 --> 00:33:08,140
+و ال polar body هل هم متوازين ولا لا علشان احنا
+
+478
+00:33:08,140 --> 00:33:11,740
+نحكي في الموضوع ده خلونا نشوف الصورة بتكون أفضل لو
+
+479
+00:33:11,740 --> 00:33:15,360
+احنا طلعنا على الصورة الموجودة في الأسفل بهذا
+
+480
+00:33:15,360 --> 00:33:20,120
+الشكل الصورة الموجودة في الأسفل تتحدث عن ال polar
+
+481
+00:33:20,120 --> 00:33:24,660
+و حاجة سمناها ال nuclear او ال pro nuclear
+
+482
+00:33:24,660 --> 00:33:29,200
+orientationهي أنا عندي نواة ذكرية وهي أنا عندي
+
+483
+00:33:29,200 --> 00:33:33,220
+نواة أنثوية موجودين مع بعضهم البعض في المنتصف
+
+484
+00:33:33,220 --> 00:33:38,020
+متماثلين في الحجم ملتسقين مع بعضهم البعض إذا عملية
+
+485
+00:33:38,020 --> 00:33:41,240
+ال fertilization ناجح إلى حد ما هي عند ال first
+
+486
+00:33:41,240 --> 00:33:44,280
+polar body وهي عند ال second polar body زهروا هي
+
+487
+00:33:44,280 --> 00:33:47,440
+عندي نقطة تانية تدل عن نجاح عملية ال fertilization
+
+488
+00:33:47,440 --> 00:33:51,120
+في نقطة تالتة؟ أه في نقطة تالتةإن الـ Orientation
+
+489
+00:33:51,120 --> 00:33:54,360
+الخاص بالـ Prone Nuclear تتماشى مع الـ Orientation
+
+490
+00:33:54,360 --> 00:33:57,060
+الخاصة بالـ Polar Body شو يعني؟ يعني الـ Polar
+
+491
+00:33:57,060 --> 00:34:01,980
+Body توازى لـ Prone Nuclear معناه إن عملية ال
+
+492
+00:34:01,980 --> 00:34:06,360
+fertilization عملية ناجحة بشكل كامل جدا، هذا معناه
+
+493
+00:34:06,360 --> 00:34:11,360
+الـ Parallel أو التوازىالصورة التانية هي خلّينا
+
+494
+00:34:11,360 --> 00:34:15,860
+نضع خط بهذا الشكل و نضع خط بهذا الشكل مافي عندى
+
+495
+00:34:15,860 --> 00:34:20,700
+عملية توازي ما بين الـ polar body location و ال
+
+496
+00:34:20,700 --> 00:34:25,040
+pronuclear location فهم not parallelفبالتالي مش
+
+497
+00:34:25,040 --> 00:34:28,500
+متوازين فبالتالي ال orientation غير صحيح يعني
+
+498
+00:34:28,500 --> 00:34:32,800
+عملية ال fertilization فاشلة بنسبة كبيرة جدا وقد
+
+499
+00:34:32,800 --> 00:34:36,540
+تؤدي إلى chromosome ال abnormality أو تأخر في
+
+500
+00:34:36,540 --> 00:34:41,200
+انقسام الجنين إذن فهمنا إيش المقصود بال pronuclear
+
+501
+00:34:41,200 --> 00:34:45,020
+orientation طب عملية التقييم في اليوم التاني و
+
+502
+00:34:45,020 --> 00:34:48,830
+اليوم التالت هل إلهامعايير معينة أكيد إلها معايير
+
+503
+00:34:48,830 --> 00:34:52,290
+معينة في اليوم التاني من عملية الـ insemination
+
+504
+00:34:52,290 --> 00:34:58,050
+أهم معيار ظهور ال 4-plastomere ومقصود فيها إن أنا
+
+505
+00:34:58,050 --> 00:35:02,010
+عندي خلية كبيرة هي الـboidal في الأصل صار في عندي
+
+506
+00:35:02,010 --> 00:35:05,690
+خلية صغيرة في الداخل وهي عبارة عن نتج انقسم النواء
+
+507
+00:35:05,690 --> 00:35:08,690
+اندماج النواء الذكرية مع الأنثوية فقدرت تكون خلية
+
+508
+00:35:08,690 --> 00:35:12,870
+بعد كده الخلية تحت القسم اللاتنتين وهي داخلجدار
+
+509
+00:35:12,870 --> 00:35:16,370
+البويضة والتنتير حيصيروا 4 والاربع حيصيروا 16 كل
+
+510
+00:35:16,370 --> 00:35:20,030
+خلية من هذه الخلايا بنسميها Plastomera فلازم يكون
+
+511
+00:35:20,030 --> 00:35:24,430
+انا عندى في اليوم التانى اربع خلايا بنسميها four
+
+512
+00:35:24,430 --> 00:35:28,050
+embryonic cells او four Plastomera دول ال four
+
+513
+00:35:28,050 --> 00:35:31,610
+Plastomera لازم يكونوا متمثلين في الحجم ومافيش
+
+514
+00:35:31,610 --> 00:35:33,970
+عندهم حجة بنسميها no multinucleation
+
+515
+00:35:33,970 --> 00:35:37,130
+والpsychoplasm of each Plastomera should be pale
+
+516
+00:35:37,130 --> 00:35:41,730
+and clear sometime some granulationوالـ
+
+517
+00:35:41,730 --> 00:35:45,250
+fragmentation should be appeared around 20% وفي
+
+518
+00:35:45,250 --> 00:35:48,430
+اليوم التاني او اليوم التالت بقدر انا اقيم الجنين
+
+519
+00:35:48,430 --> 00:35:53,850
+الى grade 1 و2 و3 و4 1 هو الأفضل على الإطلاق بيكون
+
+520
+00:35:53,850 --> 00:35:57,790
+الخلايا الأربع بلاستوميرة الموجودة جوا متماثلة في
+
+521
+00:35:57,790 --> 00:36:03,410
+الحجم مافي عندي متماثلين في الحجم equal in the
+
+522
+00:36:03,410 --> 00:36:05,870
+size no cytoplasmic fragmentation in the result
+
+523
+00:36:05,870 --> 00:36:09,960
+يعني بمعنى أخر الأربع خلاياعبارة عن خلايا متمثلة
+
+524
+00:36:09,960 --> 00:36:12,800
+في الحجم بشكل كبير جدا والـ Fragmentation غير
+
+525
+00:36:12,800 --> 00:36:16,140
+موجود داخل الـ Cytoplasm فبسميها grade 1 وهي أفضل
+
+526
+00:36:16,140 --> 00:36:20,280
+أنواع على الإطلاق grade 2 بتكون الخلايا إلى حد ما
+
+527
+00:36:20,280 --> 00:36:24,320
+مختلفة اختلاف بسيط وفيه Cytoplasm Fragmentation
+
+528
+00:36:24,320 --> 00:36:28,900
+بسيط grade 3 الخلايا مختلفة في الحجم وفي عند الـ
+
+529
+00:36:28,900 --> 00:36:32,720
+Fragmentation واضح grade 4 الخلايا غير متمثلة في
+
+530
+00:36:32,720 --> 00:36:37,140
+الحجم و Fragmentation عالي جدا جدا جداطب انا لما
+
+531
+00:36:37,140 --> 00:36:40,940
+بدى ارجع لرحمة سيدة ارجع grade one ولا اتنين ولا
+
+532
+00:36:40,940 --> 00:36:45,460
+تلاتة ولا اربع برجع grade واحد على كل الأوجه مافيش
+
+533
+00:36:45,460 --> 00:36:49,680
+برجع grade اتنين مافيش برجع grade تلاتة ولكن اول
+
+534
+00:36:49,680 --> 00:36:53,160
+chance عندي لازم ارجع grade واحد و grade اتنين
+
+535
+00:36:53,160 --> 00:36:56,400
+طبعا في اليوم التالت لازم يصير عند الأربع خلايا
+
+536
+00:36:56,400 --> 00:36:59,660
+تصير تمان خلايا وفي اليوم الرابع التمان خلايا لازم
+
+537
+00:36:59,660 --> 00:37:05,280
+يصيروا ستة عشر خلية عشان كده عمليت انقسامخلية تصبح
+
+538
+00:37:05,280 --> 00:37:10,860
+2 و 2 يصبح 4 و 4 يصبح 8 و 8 يصبح 16 و 16 يصبح 32 و
+
+539
+00:37:10,860 --> 00:37:16,100
+32 يصبح 64 .. و هكذافي اليوم التالت اللي حكينا فيه
+
+540
+00:37:16,100 --> 00:37:20,420
+ان عدد الخلايا لازم تصير 8 خلايا بنسمي هذا ال
+
+541
+00:37:20,420 --> 00:37:24,520
+stage موريلا موريلا stage وهي عبارة عن مرحلة من
+
+542
+00:37:24,520 --> 00:37:28,160
+مراحل تطور انقسام الجنين حيث تصل عدد الخلايا فيه
+
+543
+00:37:28,160 --> 00:37:34,400
+إلى 8 خلايا على الإطلاق 8 plus 2 ميرة 8 plus 2
+
+544
+00:37:34,400 --> 00:37:40,180
+ميرة بنسمي ال structure ككل موريلا طبعابعض ال ..
+
+545
+00:37:40,180 --> 00:37:43,900
+هدف يسموها Morella
+
+546
+00:37:43,900 --> 00:37:49,240
+The pre-embryo is around 60 cell stage شو معناها؟
+
+547
+00:37:49,240 --> 00:37:53,380
+أنا ما بقدر أسمي الخلايا هذه اللي كانت تمانية و
+
+548
+00:37:53,380 --> 00:37:56,960
+اللي كانت أربع و اللي كانت اتنين ماقدرش أسميها
+
+549
+00:37:56,960 --> 00:38:03,720
+embryo بقدر أسميها 2PN بقدر أسميها زي God بقدر
+
+550
+00:38:03,720 --> 00:38:09,430
+أسميها Plastomere إذا كانت أربع خلاياولكن لما تصل
+
+551
+00:38:09,430 --> 00:38:14,230
+أعتاب ال 16 خلية في اليوم الرابع ببدأ أسميها
+
+552
+00:38:14,230 --> 00:38:17,750
+embryo ببدأ أسميها embryo يعني حتى في اليوم التاني
+
+553
+00:38:17,750 --> 00:38:21,610
+.. التالت لما صار في عندي 8 خلايا ما بقدر أسميها
+
+554
+00:38:21,610 --> 00:38:25,810
+embryo بسميها موريلا لما اتصل أعتاب ال 16 خلية
+
+555
+00:38:25,810 --> 00:38:30,470
+ببدأ أسميها embryo ببدأ أسميها embryo طبعا هي عندي
+
+556
+00:38:30,880 --> 00:38:34,680
+بداية رسمة بتوضح الكلام اللي أنا حكيته انا عندي
+
+557
+00:38:34,680 --> 00:38:38,380
+الخلية او ال void المخصبة بعد ما اتخصبت صارت اسمها
+
+558
+00:38:38,380 --> 00:38:44,540
+zygote لإنها عندي two PN في المنتصف و close مع بعض
+
+559
+00:38:44,540 --> 00:38:48,880
+البعض فبسم الخلية ككل zygote هذه الخلية انقسمت إلى
+
+560
+00:38:48,880 --> 00:38:53,480
+two cell في اليوم الأول بعدين صارت أربع خلايا في
+
+561
+00:38:53,480 --> 00:38:56,260
+اليوم التاني في اليوم التالت صارت تمان خلايا
+
+562
+00:38:56,260 --> 00:39:00,950
+سميتها morellaبعد كده التمن خلية هيصيروا 16 خلية و
+
+563
+00:39:00,950 --> 00:39:05,510
+ال 16 هيصيروا 32 خلية بسميها بعد ال 16 خلية بسميها
+
+564
+00:39:05,510 --> 00:39:12,050
+Plastocyst و لما اتصل الى 16 خلية ببدأ أسميها
+
+565
+00:39:12,050 --> 00:39:16,860
+Imperium بشكل كامل صورة بتوضحالكلام اللي احنا
+
+566
+00:39:16,860 --> 00:39:21,820
+حكيناه بشكل اخر هي انا عندي ال mature oocyte
+
+567
+00:39:21,820 --> 00:39:26,200
+صارلها fertilization أدت إلى حدوث zygote ال zygote
+
+568
+00:39:26,200 --> 00:39:29,360
+صارت two cell في اليوم الأول أربع في اليوم التاني
+
+569
+00:39:29,360 --> 00:39:32,840
+تمانية في اليوم التالت وهي الموريلا أو من تمانية
+
+570
+00:39:32,840 --> 00:39:36,540
+إلى ستاشر بعض الأحيان بيسموها وplastocyst إذا كانت
+
+571
+00:39:36,540 --> 00:39:39,640
+بعد عتاب ستاشر خلية يعني لما انا أجي أقولك
+
+572
+00:39:39,640 --> 00:39:43,060
+الموريلا عدد خلاياها بتقوللي الموريلا هي عبارة عن
+
+573
+00:39:43,060 --> 00:39:45,990
+مركبأو عبارة عن خلية أو عبارة عن الـ structure
+
+574
+00:39:45,990 --> 00:39:49,690
+يظهر في اليوم التالت من القسام من بعد عملية ال
+
+575
+00:39:49,690 --> 00:39:54,990
+fertilization تحتوي على 8 ل 16 خلية لبساطة جدا
+
+576
+00:39:54,990 --> 00:39:58,290
+لازم يكون على شكل ال range خلّيني أشوف كيف بيصير
+
+577
+00:39:58,290 --> 00:40:06,070
+عملية ال cleavage لل embryo بفيديو بسيط جدا طبعا
+
+578
+00:40:06,070 --> 00:40:10,650
+هذه عملية ال cleavage اتكلم عليها من البداية في
+
+579
+00:40:10,650 --> 00:40:14,280
+اليوم الأول والتاني والتالت والرابعهذه الواجهة
+
+580
+00:40:14,280 --> 00:40:16,940
+فيها انت خلية اتنين تلاتة اربع خلايا خمس خلايا
+
+581
+00:40:16,940 --> 00:40:21,880
+صاروا ستة اذا سبعة في اليوم التالت لازم يصلوا ل
+
+582
+00:40:21,880 --> 00:40:34,700
+تمام خلايا على كل خلية بتاعة اتنين هذه القصة هذه
+
+583
+00:40:34,700 --> 00:40:37,780
+طبعا ال stage of memorella مابتقدر تميز الخلايا و
+
+584
+00:40:37,780 --> 00:40:45,920
+هنتكلم عنها الصفات كل stage من different phasesالـ
+
+585
+00:40:45,920 --> 00:40:49,060
+Plastocyst Formation نفسنا نستطيع أن نقول إنها
+
+586
+00:40:49,060 --> 00:40:53,980
+خلية منفصلة عن الأخرى فلس ال line اختفت مباشرة
+
+587
+00:40:53,980 --> 00:40:55,440
+الحدود اختفت
+
+588
+00:41:05,760 --> 00:41:09,100
+أوريلا بدأت تزيد في الحجم تحت مصطلح expand عشان
+
+589
+00:41:09,100 --> 00:41:13,120
+تزيد حجمها بعد كده الحدود الخارجية اللي كانت خاصة
+
+590
+00:41:13,120 --> 00:41:17,500
+بالـ Oocyte مابتقدر تستحمل كمية الضغط الموجود بفعل
+
+591
+00:41:17,500 --> 00:41:21,240
+تمدد البلاستوكست فبدها نوع من أنواع الفجوات تتصير
+
+592
+00:41:21,240 --> 00:41:27,680
+عشان يصيرها releasing وزيادة في التمددطبعا هذه
+
+593
+00:41:27,680 --> 00:41:32,800
+امارة عن صورة بتوضح ليه عملية الـ Cleavage في
+
+594
+00:41:32,800 --> 00:41:36,420
+اليوم الخامس والسادس اللي بنتسميه Plastocyst Stage
+
+595
+00:41:36,420 --> 00:41:41,080
+بيحدث أو تصل الخلية أو البويضة المخصبة إلى الـ
+
+596
+00:41:41,080 --> 00:41:46,900
+Plastocyst Stage المفروض بعد 112 ساعة إلى 114 ساعة
+
+597
+00:41:46,900 --> 00:41:50,160
+من عملية ال injection هذا في الوضع الطبيعييعني في
+
+598
+00:41:50,160 --> 00:41:53,620
+الوضع الطبيعي صار ال injection الساعة ستة صباحا أو
+
+599
+00:41:53,620 --> 00:41:57,860
+ستة مساء عيد 112 ساعة المفروض الخلية تكون وصلت
+
+600
+00:41:57,860 --> 00:42:02,940
+لبلاستوست أو وصلت لليوم الخامس البلاستوست has two
+
+601
+00:42:02,940 --> 00:42:06,000
+..يعني البلاستوست بشكل أساسي في عندها نوعين من
+
+602
+00:42:06,000 --> 00:42:09,440
+الخلايا الخلية الكبيرة هذه اللي صار فيها expansion
+
+603
+00:42:09,440 --> 00:42:12,760
+في الفيديو السابق بيصير فيها نوعين من الخلايا
+
+604
+00:42:12,760 --> 00:42:15,640
+الخلية الأولى بنسميها inner cell mass والخلاية
+
+605
+00:42:15,640 --> 00:42:21,580
+التانية بنسميها differentiatedوكل خلية مسؤولة عن
+
+606
+00:42:21,580 --> 00:42:26,000
+إنتاج نوع من أنواع الخلايا الموجودة في أجسامنا في
+
+607
+00:42:26,000 --> 00:42:30,340
+عندي مرحلتين من الـplasticist المرحلة الأولى هي
+
+608
+00:42:30,340 --> 00:42:33,200
+عبارة عن ال early plasticist والتانية ال later
+
+609
+00:42:33,200 --> 00:42:38,660
+plasticist ال early ال embryo بيظل كما هو the same
+
+610
+00:42:38,660 --> 00:42:44,560
+size and zona has its same thickness في مرحلة ال
+
+611
+00:42:44,560 --> 00:42:49,090
+early ال embryo بيكونحجمه كما هو ثابت مافي عندى
+
+612
+00:42:49,090 --> 00:42:52,010
+زيادة في الحجم والزناب اللي سيدة بتكون لها نفس ال
+
+613
+00:42:52,010 --> 00:42:56,050
+thickness ما اتغيرت عشان كده لسه مادخلتش في مرحلة
+
+614
+00:42:56,050 --> 00:43:01,130
+التمددPlastocyst cavity beginning to enlargement
+
+615
+00:43:01,130 --> 00:43:04,710
+في نهاية هذه ال stage بيصير انديسيل beginning to
+
+616
+00:43:04,710 --> 00:43:08,070
+distinction into outer layer سميتها trophoplast و
+
+617
+00:43:08,070 --> 00:43:12,230
+inner layer في ال later stage ال embryo بيبدأ في
+
+618
+00:43:12,230 --> 00:43:16,070
+الزيادة في الحجم اللي سميتها الزيادة في الحجم أو
+
+619
+00:43:16,070 --> 00:43:18,130
+ال expansion بنسميها زيادة في الحجم أو ال
+
+620
+00:43:18,130 --> 00:43:24,150
+expansionباليو سيدا بتبدأ تكون أخف من حيث الصمك
+
+621
+00:43:24,150 --> 00:43:29,870
+علشان تبدأ السماح للخلايا أنها تخرج وتتمدد و ال
+
+622
+00:43:29,870 --> 00:43:33,610
+plastic coal and inner cell mass become large و
+
+623
+00:43:33,610 --> 00:43:40,350
+هذا كلام مش كتير حنهتم فيه في آخر في آخر فقرة أنا
+
+624
+00:43:40,350 --> 00:43:44,960
+بهمنيإنه زيادة في الحجم و الـ zoonableucida ببدأ
+
+625
+00:43:44,960 --> 00:43:48,860
+في عملية thinner من حيث ال sickness الخاص فيها
+
+626
+00:43:48,860 --> 00:43:53,840
+صورة بتوضح ال embryonic stem cell في اليوم الأول و
+
+627
+00:43:53,840 --> 00:43:57,000
+بعدين اليوم التاني و بعدين اليوم التالت و الرابع و
+
+628
+00:43:57,000 --> 00:44:00,360
+الخامس أو من الخامس ل السابع طبعا هذه الخلية اللي
+
+629
+00:44:00,360 --> 00:44:03,100
+في الداخل بنسميها embryonic stem cell
+
+630
+00:44:06,550 --> 00:44:09,850
+تحتوي على مادة وراثية تشبه المادة الوراثية التي
+
+631
+00:44:09,850 --> 00:44:13,230
+سوف تظهر عند الجنين فبالتالي لو أنا أخذت خلية
+
+632
+00:44:13,230 --> 00:44:16,810
+واحدة منهم ممكن أشخص الجنين هل هو male أو female؟
+
+633
+00:44:16,810 --> 00:44:20,010
+وإيش طبيعة الأمراض الوراثية اللي ممكن تظهر عنده؟
+
+634
+00:44:20,010 --> 00:44:23,130
+هذه ال embryonic stem cell تعتبر polypotence إيش
+
+635
+00:44:23,130 --> 00:44:27,370
+يعني polypotence؟ يعني تستطيع أن تعطي أي نوع من
+
+636
+00:44:27,370 --> 00:44:31,150
+أنواع القلاي الموجودة في أجسامنا هذه بنسميها
+
+637
+00:44:31,150 --> 00:44:37,510
+polypotence cellصورة أخرى تتكلم عن عملية الانقسام
+
+638
+00:44:37,510 --> 00:44:42,090
+طبعا هذه ال fertilized egg الموجودة على اليسار
+
+639
+00:44:42,090 --> 00:44:45,910
+بالأعلى صار عندي two cell في اليوم الأول four cell
+
+640
+00:44:45,910 --> 00:44:51,750
+ات cell صار في عندي خلايا متداخلة مع بعض البعض
+
+641
+00:44:51,750 --> 00:44:55,170
+مختفية الحدود ما بينهم هي ال morella و الموريلا
+
+642
+00:44:55,170 --> 00:44:58,270
+هتنقسم فيما بعد للوصول الى ال early stage من ال
+
+643
+00:44:58,270 --> 00:45:01,940
+plastocystو ال later stage من ال blastocyst في
+
+644
+00:45:01,940 --> 00:45:07,800
+اليوم الخامس إلى اليوم السابع إذا أنا خلصت مراحل
+
+645
+00:45:07,800 --> 00:45:11,980
+ال cleavage الخاصة بيهالـ embryo هنتكلم عنها بشكل
+
+646
+00:45:11,980 --> 00:45:15,940
+آخر في ال chapter القادم كيف يمكن أن نحصل على
+
+647
+00:45:15,940 --> 00:45:19,960
+بيوبسي من ال embryo لتشخيص بعض الأمراض الوراثية
+
+648
+00:45:19,960 --> 00:45:24,240
+كيف يمكن تشخيص الأمراض الوراثية من خلال الحصول على
+
+649
+00:45:24,240 --> 00:45:29,560
+embryonic biopsy أو embryo biopsy أو الحصول على
+
+650
+00:45:29,560 --> 00:45:33,390
+بيوبسي من ال polar، بنسميه polar body biopsyطبعا
+
+651
+00:45:33,390 --> 00:45:37,550
+مش هبترخص فيه، هنتكلم فيه بالإضافة إلى ال sex
+
+652
+00:45:37,550 --> 00:45:41,850
+determination أو ال gender selection في مصطلح جديد
+
+653
+00:45:41,850 --> 00:45:45,330
+بيستخدموه في مصطلح جديد بيستخدموه وهو عبارة عن ال
+
+654
+00:45:45,330 --> 00:45:50,170
+IUI وهو عبارة عن ال intrauterine insemination يعني
+
+655
+00:45:50,170 --> 00:45:54,970
+بمعنى آخر الحقن داخل الرحم طبعا هذا مصطلح يستخدم
+
+656
+00:45:54,970 --> 00:45:58,770
+في حالات معينة عند .. عند couples اللي هم مشكلة في
+
+657
+00:45:58,770 --> 00:46:04,260
+معينة بمعنى أنه ال male طبيعيةالفميل الطبيعي ولكن
+
+658
+00:46:04,260 --> 00:46:07,340
+ال spermatozoa الموجودة بعد عملية ال ejaculation
+
+659
+00:46:07,340 --> 00:46:13,700
+inside the vagina بيصير عنده مشكلة في وصول
+
+660
+00:46:13,700 --> 00:46:18,920
+ال spermatozoa إلى ال fallopian tube هنا عبارة عن
+
+661
+00:46:18,920 --> 00:46:23,390
+المشكلةطبعا في هذا النوع من أنواع ال «couples» أو
+
+662
+00:46:23,390 --> 00:46:25,610
+هؤلاء المشاكل اللي بتواجه ال «couples» بيكون فيه
+
+663
+00:46:25,610 --> 00:46:27,790
+أنا عند ال «couples» عادة من حيث عدد ال
+
+664
+00:46:27,790 --> 00:46:32,010
+spermatozoa أو ال morphology ولكن بعد عملية ال
+
+665
+00:46:32,010 --> 00:46:34,790
+ejaculation inside the vagina في مشاكل بتواجه ال
+
+666
+00:46:34,790 --> 00:46:38,490
+spermatozoa ما بتقدر تخترق ال cervix خصوصا إذا كان
+
+667
+00:46:38,490 --> 00:46:42,410
+عند الفيميل ant sperm antibodyأو في عندها مشكلة في
+
+668
+00:46:42,410 --> 00:46:46,610
+عملية .. في الـ mucus الموجود في منطقة الـ cervic
+
+669
+00:46:46,610 --> 00:46:49,730
+أو في عنده مشكلة في الـ pH فبتقتل ال spermatozoa
+
+670
+00:46:49,730 --> 00:46:54,950
+فالطبيب بيجي بحكم كمية كبيرة جدا من ال spermatozoa
+
+671
+00:46:54,950 --> 00:46:58,810
+بقى في الرحل مباشرة في الرحل المباشرة عشان يقلل
+
+672
+00:46:58,810 --> 00:47:03,810
+فرصة تعرض ال spermatozoa إلى الأخطار التي يمكن أن
+
+673
+00:47:03,810 --> 00:47:07,520
+تتعرض لها أثناء عملية دخول ال cervicواختراف منطقة
+
+674
+00:47:07,520 --> 00:47:11,760
+الـ cervic و بيقصر المسافة اللي ممكن يقطعها ال
+
+675
+00:47:11,760 --> 00:47:14,760
+spermatozoa وصولا إلى ال fallopian tube هذه مصطلح
+
+676
+00:47:14,760 --> 00:47:20,160
+بنسميه IUI Intra-Uterine insemination is a
+
+677
+00:47:20,160 --> 00:47:22,720
+fertility treatment that involve placing
+
+678
+00:47:22,720 --> 00:47:26,600
+spermatozoa inside women uterus to facilitate
+
+679
+00:47:26,600 --> 00:47:30,360
+fertilization يعني ال spermatozoa يتم وضعها في
+
+680
+00:47:30,360 --> 00:47:34,500
+الرحم ولا يتم وضع في ال fallopian tubeالسبيرمتازوه
+
+681
+00:47:34,500 --> 00:47:37,260
+بعد ما يوضع في الرحم هو اللي هيروح ويهاجر للـ
+
+682
+00:47:37,260 --> 00:47:44,720
+Fallopian tube طبعا متى بتتم النصح بعمل I.O.I؟ هل
+
+683
+00:47:44,720 --> 00:47:48,340
+كل إنسان ممكن يعمل I.O.I؟ ولا لازم كابلز لهم صفات
+
+684
+00:47:48,340 --> 00:47:52,120
+معينة؟ لأ أكيد لازم يكون كابلز لهم صفات معينة منهم
+
+685
+00:47:52,120 --> 00:47:58,320
+ال I.O.I يعتبر inexpensive إلى حد ما يعتبر غير
+
+686
+00:47:58,320 --> 00:48:03,570
+مكلف لأن مافي أدوية تاخدها السيدةما في أدوية
+
+687
+00:48:03,570 --> 00:48:06,650
+بتعالج مشكلة معينة عند السيدة الخاصة السيدة ما
+
+688
+00:48:06,650 --> 00:48:10,850
+عندها مشكلة في ال ovulation ال I.O.I يعتبر أول
+
+689
+00:48:10,850 --> 00:48:16,090
+chance أو أول فكرة أو أول حل في وجه الأطباء و لازم
+
+690
+00:48:16,090 --> 00:48:21,310
+يعملوه قبل ما يروحوا إلى الإجزي بشكل مباشر ال I.O
+
+691
+00:48:21,310 --> 00:48:26,770
+.I يوصف للسيدات اللي عندهم مشاكل في منطقة ال
+
+692
+00:48:26,770 --> 00:48:31,530
+cervical نسميها cervical scar ال tissue اللي بتمنع
+
+693
+00:48:31,800 --> 00:48:36,200
+وصول الـ spermatozoa إلى الرحم فبالتالي تفقد
+
+694
+00:48:36,200 --> 00:48:41,740
+الفرصة على أو في الإنجاب تفقد الفرصة في الإنجاب
+
+695
+00:48:41,740 --> 00:48:46,300
+هذا بالنسبة لل IOI شغلة تانية ال IOI يوصف لبعض
+
+696
+00:48:46,300 --> 00:48:49,340
+الحالات اللي عندهم mild male factor infertility
+
+697
+00:48:49,340 --> 00:48:53,160
+unexplained infertility الناس اللي يعتبروا
+
+698
+00:48:53,160 --> 00:48:56,020
+infertile بسبب جهاز المناع اللي بتسميه
+
+699
+00:48:56,020 --> 00:48:59,640
+immunological infertilityالناس اللي عندهم مشاكل في
+
+700
+00:48:59,640 --> 00:49:02,880
+ال ejaculation .. okay فيه spermatozoa بيصير
+
+701
+00:49:02,880 --> 00:49:06,280
+intercourses ولكن المشكلة في ال ejaculation ما
+
+702
+00:49:06,280 --> 00:49:11,160
+بيصلّى الحد المسموح فيه فبالتالي كمية و عدد ال
+
+703
+00:49:11,160 --> 00:49:13,660
+spermatozoa اللي بتصل لل cervic و تستطيع تخترق ال
+
+704
+00:49:13,660 --> 00:49:18,040
+cervic بتكون قليلة جدا طبعا هتتدمر و تتلف أثناء
+
+705
+00:49:18,040 --> 00:49:20,740
+الرحلة الطويلة فبالتالي فرصة ال fertilization
+
+706
+00:49:20,740 --> 00:49:24,500
+ضعيفة الناس اللي عندها endomateriosis اللي عندهم
+
+707
+00:49:24,500 --> 00:49:30,780
+ovarian dysfunctionمشاكل في التبيول if the male
+
+708
+00:49:30,780 --> 00:49:34,840
+parent sperm count motility or shape is less than
+
+709
+00:49:34,840 --> 00:49:38,680
+adequate or normal if the female cervical mucous
+
+710
+00:49:38,680 --> 00:49:43,600
+is very thick IUI will allow the spermto transfer
+
+711
+00:49:43,600 --> 00:49:49,620
+and overcome the mucus في فحص بيسموه PCT مهم جدا
+
+712
+00:49:49,620 --> 00:49:56,840
+هذا الفحص و هو ال postcoital test أو بمعنى فحص ما
+
+713
+00:49:56,840 --> 00:50:01,740
+بعد الجبع ببساطة جدا يستخدم إذا كان في عند ال
+
+714
+00:50:01,740 --> 00:50:07,120
+couples مشكلة في انتقال ال spermatozoa و اختراق
+
+715
+00:50:07,120 --> 00:50:13,640
+منطقة ال cervicالطبيب أو الطبيبة بيطلب من الـ
+
+716
+00:50:13,640 --> 00:50:17,880
+couples إنهم يعملوا فحص الـ BCT بيصير interaction
+
+717
+00:50:17,880 --> 00:50:20,360
+و intercourse بيبقى بين ال two couples بعدين
+
+718
+00:50:20,360 --> 00:50:23,000
+الطبيبة بتيجي و بتاخد swap مباشرة بعد ال
+
+719
+00:50:23,000 --> 00:50:28,500
+intercourse من منطقة ال cervic بتقسمها part one
+
+720
+00:50:28,500 --> 00:50:32,370
+part two part threeوبتشوف وين ال spermatozoa هل ال
+
+721
+00:50:32,370 --> 00:50:35,250
+spermatozoa أخر part تواجد فيها part 1 فبالتالي
+
+722
+00:50:35,250 --> 00:50:38,770
+part 2 و part 2 part 2 و part 3 مافيها spermatozoa
+
+723
+00:50:38,770 --> 00:50:42,730
+في في part 1 و part 2 وفيش في part 3 فمعناه بتحدد
+
+724
+00:50:42,730 --> 00:50:46,210
+المسافة أو أقصى مسافة ممكن تقطعها ال spermatozoa
+
+725
+00:50:46,210 --> 00:50:51,650
+وبناء عليه ممكن تحدد هل تحتاج إلى IOI أم تحتاج إلى
+
+726
+00:50:51,650 --> 00:50:57,590
+IVF أم تحتاج إلى ECG ولكن ال IOI في الغالببيستخدم
+
+727
+00:50:57,590 --> 00:51:01,950
+لـ two couples normal بشكل عام جدا ال female ما
+
+728
+00:51:01,950 --> 00:51:04,370
+عندها أي مشاكل هرمونية ما عندها مشاكل في الطويد ما
+
+729
+00:51:04,370 --> 00:51:08,130
+عندها مشاكل في عدد البويضات ال male ما عنده مشاكل
+
+730
+00:51:08,130 --> 00:51:12,070
+في عدد الحيارات ما عنده مشاكل في ال morphology ال
+
+731
+00:51:12,070 --> 00:51:16,030
+seam البراميض الطبيعي ولكن مشكلة في عملية الانتقال
+
+732
+00:51:16,030 --> 00:51:19,690
+واختراق و التغلب على منطقته و العواقق الموجودة في
+
+733
+00:51:19,690 --> 00:51:23,190
+منطقة ال cervic للوصول إلى الleotard هذا المشكلة
+
+734
+00:51:23,190 --> 00:51:29,310
+الوحيدة المشكلة تحل باستخدامالـ I&I إلى حد ما I&I
+
+735
+00:51:29,310 --> 00:51:33,370
+involve pre-procedure evaluation including
+
+736
+00:51:33,370 --> 00:51:36,550
+physical clinical lab evaluation of to determine
+
+737
+00:51:36,550 --> 00:51:40,790
+the duration and causes of infertility, semen
+
+738
+00:51:40,790 --> 00:51:44,410
+quality, functional tubule status and follicular
+
+739
+00:51:44,410 --> 00:51:49,210
+and uterine status يعني أي two couples بدون يخضعوا
+
+740
+00:51:49,210 --> 00:51:52,690
+للـ I&I لازم يخضعوا لعملية evaluation قبل كل شيء
+
+741
+00:51:52,690 --> 00:51:56,640
+عشان يحددوا الـ semen parameter equality ككفيةيحدد
+
+742
+00:51:56,640 --> 00:51:59,900
+ال duration لل infertility و أسبابها كيف ال
+
+743
+00:51:59,900 --> 00:52:02,900
+function بتاعة ال ovary الخاصة بالسيدة هو بيعي مش
+
+744
+00:52:02,900 --> 00:52:06,400
+طبيعي؟ في مشكلة في ال tubule ولا لأ؟ و ال follicle
+
+745
+00:52:06,400 --> 00:52:09,980
+كيف وضعها؟ و الرحم كيف وضعه؟ ممكن يبني بطانة الرحم
+
+746
+00:52:09,980 --> 00:52:11,960
+فيها inflammation؟ مش فيها inflammation؟ فيها
+
+747
+00:52:11,960 --> 00:52:16,460
+infection؟ أمر طبيعي جدا لأنه مش منطق الطبيب يروح
+
+748
+00:52:16,460 --> 00:52:21,040
+يعمل I.O.I و تكون المشكلة أصلا مش في عملية التغلب
+
+749
+00:52:21,040 --> 00:52:23,220
+و قطع مسافة ال cervical يكون المشكلة في
+
+750
+00:52:29,900 --> 00:52:34,500
+لازم يكون كل شيء طبيعي باستثناء المسافة التي سوف
+
+751
+00:52:34,500 --> 00:52:39,240
+يقطعها ال spermatozoon للتغلب علىمنطقة الـ cervic
+
+752
+00:52:39,240 --> 00:52:42,240
+ساعتها انا بقدر اقول والله هدولة ال couples
+
+753
+00:52:42,240 --> 00:52:46,620
+هيحتاجوا الى IUI control ovarian hyper stimulation
+
+754
+00:52:46,620 --> 00:52:50,380
+with close monitoring of leukogenesis and
+
+755
+00:52:50,380 --> 00:52:54,300
+ovulation to avoid a side effect like ovarian
+
+756
+00:52:54,300 --> 00:52:56,700
+hyper stimulation syndrome حتى السيدات اللي
+
+757
+00:52:56,700 --> 00:53:01,140
+هيخضعوا على ال IUI نادر مايروحوا يعملوا induction
+
+758
+00:53:01,140 --> 00:53:05,760
+يعملوا stimulation لأن وضعهم طبيعي ولكن في بعض
+
+759
+00:53:05,760 --> 00:53:09,980
+الأحيان علشانيكون عندى فرصة نجاح عالية جدا بعمل
+
+760
+00:53:09,980 --> 00:53:15,000
+stimulation خفيف مسيطر عليه عشان اتجنب اي ovarian
+
+761
+00:53:15,000 --> 00:53:21,140
+hyper stimulation syndrome as side effect ال IOI
+
+762
+00:53:21,140 --> 00:53:25,160
+is preferred conception enhancing technique for
+
+763
+00:53:25,160 --> 00:53:30,080
+women less than 35 years functional tube short
+
+764
+00:53:30,080 --> 00:53:34,430
+period of infertility moderatemale infertility هذا
+
+765
+00:53:34,430 --> 00:53:39,270
+أكثر الشخصيات اللي ينصح لهم أن عمر السيدة أقل من
+
+766
+00:53:39,270 --> 00:53:42,770
+35 تبعه اللي عندنا normal من حيث ال functional و
+
+767
+00:53:42,770 --> 00:53:45,810
+ال structure ال infertility time و duration قصيرة
+
+768
+00:53:45,810 --> 00:53:51,810
+جدا و infertility severity عند ال male moderate or
+
+769
+00:53:51,810 --> 00:53:56,380
+mildطبعا بالنسبة لل IOI cycle perform before
+
+770
+00:53:56,380 --> 00:54:00,300
+consider alternative therapy such as IVF إذا فشل
+
+771
+00:54:00,300 --> 00:54:07,360
+ال IOI بتروح سيدة لل IVF فشلة ال IVF بتروح لعمليات
+
+772
+00:54:07,360 --> 00:54:12,440
+LHZ هذا المنطقه يقول كده طبعا في عندي بعض المعوقات
+
+773
+00:54:12,440 --> 00:54:17,660
+أو خليني أسميها contraindication
+
+774
+00:54:17,660 --> 00:54:21,180
+ال IOI may be contraindication in women with sperm
+
+775
+00:54:21,180 --> 00:54:24,800
+immunoimmobilized antibody في بعض الأحيان بعض
+
+776
+00:54:24,800 --> 00:54:32,340
+التحذيرات ال I.O.I مهم جدا انه يستخدم للتغلب على
+
+777
+00:54:32,340 --> 00:54:35,800
+المشاكل التي تظهر عند السيدات إذا كانت المشاكل لها
+
+778
+00:54:35,800 --> 00:54:40,420
+علاقة بجهاز المنع بجهاز المنع ال antibody secreted
+
+779
+00:54:40,420 --> 00:54:42,380
+in the female reproductive tract that may be
+
+780
+00:54:42,380 --> 00:54:45,960
+impaired sperm passage inhibit fertilization and
+
+781
+00:54:45,960 --> 00:54:48,880
+prevent normal post fertilization process و هذا
+
+782
+00:54:48,880 --> 00:54:54,220
+الكلام اتكلمنا عنه انه من اهمالمشاكل التي تؤدي إلى
+
+783
+00:54:54,220 --> 00:54:59,520
+اللجوء لل IOI وجود antibody ضد الـ spermatozoa عند
+
+784
+00:54:59,520 --> 00:55:02,940
+الفيماية عند الفيماية troubles with severe male
+
+785
+00:55:02,940 --> 00:55:08,480
+factor abnormal pelvic anatomy cannot be performed
+
+786
+00:55:08,480 --> 00:55:12,040
+or corrected by micro surgical repair يعني بعض
+
+787
+00:55:12,040 --> 00:55:16,360
+السيدات بيكون عندهم ال pelvic anatomy غير طبيعي
+
+788
+00:55:17,370 --> 00:55:21,090
+فبالتالي لا يمكن تعديله بعملية جراحية فبترجع إلى
+
+789
+00:55:21,090 --> 00:55:24,230
+ال IUI شو بيصير في ال insemination شو بيصير في ال
+
+790
+00:55:24,230 --> 00:55:28,750
+IUI ببساطة جدا بيقول ليه انه is pre-performed at
+
+791
+00:55:28,750 --> 00:55:33,510
+the time of ovulation usually 24 to 36 hours after
+
+792
+00:55:33,510 --> 00:55:38,150
+LH surge or peak is detected or after trigger
+
+793
+00:55:38,150 --> 00:55:43,210
+injection of HCG is administrated بمعنى آخر ان ال
+
+794
+00:55:43,210 --> 00:55:49,260
+IUI بتحدث بعد عمليةأو ظهور الـ LH Peak أو الـ LH
+
+795
+00:55:49,260 --> 00:55:55,800
+Surge بوقت يقدر بـ 24 ساعة أو 36 ساعة وهي عبارة عن
+
+796
+00:55:55,800 --> 00:55:58,940
+وقت الـ ovulation إذا بتتذكروا أو إذا هو بده
+
+797
+00:55:58,940 --> 00:56:03,600
+يعملها stimulation و induction لازم تصير بعد
+
+798
+00:56:03,600 --> 00:56:08,740
+إعطاءها القبرة التفجير اللي سميناها Sheragon وهي
+
+799
+00:56:08,740 --> 00:56:14,680
+عبارة عن مادة تحتوي على الـ HCG in the case of
+
+800
+00:56:14,680 --> 00:56:17,940
+husband inseminationالمايل should be giving the
+
+801
+00:56:17,940 --> 00:56:21,720
+sample in the same day of insemination و هذه ال
+
+802
+00:56:21,720 --> 00:56:25,420
+sample لازم يصير لها analysis عشان أعرف ال
+
+803
+00:56:25,420 --> 00:56:29,680
+parameter و أعملها purification و أعملها swarm up
+
+804
+00:56:29,680 --> 00:56:32,750
+في الغالب swarm up علشان أفرزالـ Mutile
+
+805
+00:56:32,750 --> 00:56:36,130
+spermatozoa من other spermatozoa و الـ Depressed
+
+806
+00:56:36,130 --> 00:56:40,270
+بعملها إما spermatozoa swamp up process أو بعملها
+
+807
+00:56:40,270 --> 00:56:44,850
+density gradient centrifugation بعد كده باخد ال
+
+808
+00:56:44,850 --> 00:56:49,830
+spermatozoa المطيل في حاجة بنسميها flexible
+
+809
+00:56:49,830 --> 00:56:55,830
+catheter هذه ال flexible catheter الطبيب بدخلها
+
+810
+00:56:55,830 --> 00:56:59,690
+داخل ال cervica الخاص بال female و بعمل injection
+
+811
+00:56:59,690 --> 00:57:06,770
+لل spermatozoaداخل الرحمة و بعد ذلك ستبدأ رحلتها
+
+812
+00:57:06,770 --> 00:57:11,890
+للوصول الى البويضة و التخصيبات طبعا معظم الدكاترة
+
+813
+00:57:11,890 --> 00:57:14,370
+بيعملوا recommendation ان هذه السيدة اللي قامت
+
+814
+00:57:14,370 --> 00:57:17,610
+with I.O.I لازم تبقى على ال table او على السرير
+
+815
+00:57:17,610 --> 00:57:21,690
+اللي صار فيه او عملت I.O.I فيها يعني في منطقة او
+
+816
+00:57:21,690 --> 00:57:26,660
+غرفة العملياتمدة 15 إلى 30 دقيقة بعد عملية ال
+
+817
+00:57:26,660 --> 00:57:31,620
+injection علشان تسمح للـ spermatozoa بالحركة في
+
+818
+00:57:31,620 --> 00:57:35,360
+اتجاه الفانوبيا الاتيومي ال implantation إذا كانت
+
+819
+00:57:35,360 --> 00:57:40,920
+العملية صحيحة ببدأ بعد ال 6 أيام إلى 12 يوم بعد
+
+820
+00:57:40,920 --> 00:57:44,420
+عملية ال ovulation السؤال بيطرح نفسه هل يمكن
+
+821
+00:57:44,420 --> 00:57:47,420
+استخدام ال IOI إذا كانت السيدة عندها tubule
+
+822
+00:57:47,420 --> 00:57:50,920
+ligation لأ لأن ال tubule ligation معناه أن ال
+
+823
+00:57:50,920 --> 00:57:55,410
+oocyte لن تتوفرفما فيش عندي .. إيش هستفيد من عملية
+
+824
+00:57:55,410 --> 00:58:00,550
+ال I.O.I؟ Can I.O.I be used for gender selection؟
+
+825
+00:58:00,550 --> 00:58:03,630
+بالمنطق ما بقدر أستخدم ال I.O.I لل gender
+
+826
+00:58:03,630 --> 00:58:09,190
+selection إلا إذا أنا عملت injection فقط لل sperm
+
+827
+00:58:10,070 --> 00:58:14,130
+اللي بيحمل Y كرومزوم أو ال sperm X كرومزوم وهذا
+
+828
+00:58:14,130 --> 00:58:18,610
+منطق غير مقبول لأن المسافة اللي هينتقلها ويقطعها
+
+829
+00:58:18,610 --> 00:58:22,650
+ال sperm طويلة جدا فكمية كبيرة جدا هتموت من ال
+
+830
+00:58:22,650 --> 00:58:26,190
+spermatozoa المسافة اللي هيقطعها من نهاية عمق
+
+831
+00:58:26,190 --> 00:58:30,090
+الرحم حتى ال fallopian tube وهذه مسافة طويلة إلى
+
+832
+00:58:30,090 --> 00:58:36,430
+حد ما تحتاج وقت إلى حد ما طويل تتعرض لأمور كثيرة
+
+833
+00:58:36,430 --> 00:58:39,350
+ال spermatozoa اتكلمنا عنها وشوفناها في فيديوهات
+
+834
+00:58:39,350 --> 00:58:42,840
+كثيرةفبيعمل reduction لكمية كبيرة جدا من ال
+
+835
+00:58:42,840 --> 00:58:46,620
+spermatozoa الفكرة في ال I.O.I أني أضغط أكبر عدد
+
+836
+00:58:46,620 --> 00:58:50,280
+من الحيوانات المنوية المتحركة في منطقة الرحم
+
+837
+00:58:50,280 --> 00:58:53,800
+فبالتالي ما بقدر استخدمها إذا كانت عندي tubular
+
+838
+00:58:53,800 --> 00:58:58,080
+ligation وما بقدر استخدمها لل gender selection
+
+839
+00:58:58,080 --> 00:59:03,480
+طبعا صورة بتوضح عملية ال I.O.I في صورة تانية هي
+
+840
+00:59:03,480 --> 00:59:08,700
+المبيض الأيمن و الآيسر و ال fluvial tube هي الرحم
+
+841
+00:59:09,000 --> 00:59:12,700
+هي منطقة الـ vagina وهي منطقة الـ cervic الطبيب
+
+842
+00:59:12,700 --> 00:59:16,100
+بيجيب needle مشبوكة في نهيتها flexa بال catheter
+
+843
+00:59:16,100 --> 00:59:20,360
+محملة فيها ال spermatozoa بدخل من خلال ال cervic و
+
+844
+00:59:20,360 --> 00:59:24,260
+بيعمل injection ل ال spermatozoa داخل الرحم وال
+
+845
+00:59:24,260 --> 00:59:28,300
+spermatozoa تبدأ بالهجرة إلى ال fallopian tube لكي
+
+846
+00:59:28,300 --> 00:59:33,620
+تتم عملية الطلقية خلينا نشوف الفيديو اللي بتكلم عن
+
+847
+00:59:33,620 --> 00:59:35,960
+هذا الموضوع باستفادة
+
+848
+00:59:37,460 --> 00:59:40,440
+الـ sperm that has been prepared is loaded into a
+
+849
+00:59:40,440 --> 00:59:43,880
+syringe to which a catheter is attached then the
+
+850
+00:59:43,880 --> 00:59:46,220
+speculum is introduced into the vagina allowing
+
+851
+00:59:46,220 --> 00:59:48,520
+the entrance of the neck of the uterus to be made
+
+852
+00:59:48,520 --> 00:59:51,180
+visible the catheter that has been charged with
+
+853
+00:59:51,180 --> 00:59:54,020
+sperm is introduced high into the uterus and the
+
+854
+00:59:54,020 --> 00:59:56,940
+sperm ascends through the fallopian tubes arriving
+
+855
+00:59:56,940 --> 00:59:59,960
+at the area where the oocyte is located and
+
+856
+00:59:59,960 --> 01:00:04,820
+fertilization of the oocyte is facilitated طبعا
+
+857
+01:00:04,820 --> 01:00:09,950
+هذه فكرة ال IOI ببساطة جدافي فيديو تاني بتكلم عن
+
+858
+01:00:09,950 --> 01:00:17,310
+هذا الموضوع بشكل أوسع خلّينا ننظر إليه
+
+859
+01:00:17,310 --> 01:00:22,330
+Intrauterine insemination also known as artificial
+
+860
+01:00:22,330 --> 01:00:25,590
+insemination is a procedure done to help a woman
+
+861
+01:00:25,590 --> 01:00:29,870
+get pregnant a
+
+862
+01:00:29,870 --> 01:00:33,710
+woman's reproductive system includes the vagina
+
+863
+01:00:33,710 --> 01:00:36,430
+cervix
+
+864
+01:00:39,580 --> 01:00:49,580
+Uterus Fallopian tubes and ovaries During
+
+865
+01:00:49,580 --> 01:00:52,220
+the monthly menstrual cycle, one of her ovaries
+
+866
+01:00:52,220 --> 01:00:55,840
+releases an egg in a process called ovulation
+
+867
+01:00:55,840 --> 01:00:59,200
+After
+
+868
+01:00:59,200 --> 01:01:02,200
+ovulation, the egg enters the fallopian tube
+
+869
+01:01:05,080 --> 01:01:08,180
+الفتاة أكتر ممكن أن تصبح عميقة إذا كانت لديها نفس
+
+870
+01:01:08,180 --> 01:01:15,600
+في الأيام قبل فقط، خلال أو بعد عبولة. في هذا
+
+871
+01:01:15,600 --> 01:01:19,000
+الوقت، جسد عميقة من ميزة عيونية لرجل رجل مسمى
+
+872
+01:01:19,000 --> 01:01:22,400
+سيمان قادر على تفرتيز حيوانها كما يتحرك من خلال
+
+873
+01:01:22,400 --> 01:01:27,840
+محطة الفلوبيين.يمكن
+
+874
+01:01:27,840 --> 01:01:28,540
+تفعيل عملية عملية عملية عملية عملية عملية عملية
+
+875
+01:01:28,540 --> 01:01:28,600
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+876
+01:01:28,600 --> 01:01:30,260
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+877
+01:01:30,260 --> 01:01:33,540
+عملية عملية عملي
+
+878
+01:01:34,140 --> 01:01:36,920
+أو قد يكون فعله إذا كانت المرأة تريد أن تكون لديها
+
+879
+01:01:36,920 --> 01:01:43,480
+طفل بدون شركة رجل قبل
+
+880
+01:01:43,480 --> 01:01:46,540
+إدارة الانسمينة للأطفال، يمكن أن تلقى المرأة
+
+881
+01:01:46,540 --> 01:01:49,740
+مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة
+
+882
+01:01:49,740 --> 01:01:50,360
+مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة
+
+883
+01:01:50,360 --> 01:01:50,360
+مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة
+
+884
+01:01:50,360 --> 01:01:50,660
+مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة
+
+885
+01:01:50,660 --> 01:01:59,140
+مواجهة مواجهة مواجهة مواج
+
+886
+01:01:59,420 --> 01:02:02,260
+هذا يقوم بالتركيز في الحرارة ويقوم بإزالة الحرارة
+
+887
+01:02:02,260 --> 01:02:03,940
+ويقوم بإزالة الحرارة ويقوم بإزالة الحرارة ويقوم
+
+888
+01:02:03,940 --> 01:02:05,140
+بإزالة الحرارة ويقوم بإزالة الحرارة ويقوم بإزالة
+
+889
+01:02:05,140 --> 01:02:07,280
+الحرارة ويقوم بإزالة الحرارة ويقوم بإزالة الحرارة
+
+890
+01:02:07,280 --> 01:02:07,540
+ويقوم بإزالة الحرارة ويقوم بإزالة الحرارة ويقوم
+
+891
+01:02:07,540 --> 01:02:10,440
+بإزالة الحرارة ويقوم بإزالة الحرارة ويقوم بإزالة
+
+892
+01:02:10,440 --> 01:02:15,660
+الحرارة ويقوم بإزالة الحرارة ويقوم بإزالة الحرارة
+
+893
+01:02:15,660 --> 01:02:23,120
+ويقوم بإزالة الحرارة و
+
+894
+01:02:23,940 --> 01:02:26,780
+التجارة التجارية التجارية التجارية التجارية
+
+895
+01:02:26,780 --> 01:02:27,000
+التجارية التجارية التجارية التجارية التجارية
+
+896
+01:02:27,000 --> 01:02:28,120
+التجارية التجارية التجارية التجارية التجارية
+
+897
+01:02:28,120 --> 01:02:29,220
+التجارية التجارية التجارية التجارية التجارية
+
+898
+01:02:29,220 --> 01:02:32,420
+التجارية التجارية التجارية التجارية التجارية
+
+899
+01:02:32,420 --> 01:02:37,140
+التجارية التجارية
+
+900
+01:02:37,140 --> 01:02:39,160
+التجارية التجارية التجارية التجارية التجارية
+
+901
+01:02:39,160 --> 01:02:39,160
+التجارية التجارية التجارية التجارية التجارية
+
+902
+01:02:39,160 --> 01:02:39,160
+التجارية التجارية التجارية التجارية التجارية
+
+903
+01:02:39,160 --> 01:02:39,380
+التجارية التجارية التجارية التجارية التجارية
+
+904
+01:02:39,380 --> 01:02:42,340
+التجارية التجارية التجارية التجارية التجارية
+
+905
+01:02:42,340 --> 01:02:50,360
+التجارية التجارية التجارية التجارسيرينج سيتم
+
+906
+01:02:50,360 --> 01:02:52,960
+تحميله بمقدورة صغيرة من المواظب اللي تحتوي على الـ
+
+907
+01:02:52,960 --> 01:02:57,860
+Washed Sperm ثم السيرينج سيتم إضافته إلى طب قوى
+
+908
+01:02:57,860 --> 01:03:02,540
+طويل واسمه كاثاتر الدكتور سينضغط الكاثاتر في الـ
+
+909
+01:03:02,540 --> 01:03:07,060
+Vagina فأسطول الكاثاتر سيكون مدرساً من خلال فتحة
+
+910
+01:03:07,060 --> 01:03:12,080
+في الـ cervix وإلى الـ uterus عندما يكون الكاثاتر
+
+911
+01:03:12,080 --> 01:03:15,240
+داخل الـ uterus دكتوره سينجح الـ sperm
+
+912
+01:03:18,050 --> 01:03:24,630
+Then the catheter and speculum will be removedThe
+
+913
+01:03:24,630 --> 01:03:28,070
+woman may continue to lie on her back for about 10
+
+914
+01:03:28,070 --> 01:03:34,010
+minutes طبعا هذه معظم الأمور اللي بتصير خلال ال I
+
+915
+01:03:34,010 --> 01:03:37,370
+.O.I من أجل إنجاح عملية الحقن و التغلب على ال
+
+916
+01:03:37,370 --> 01:03:41,570
+infertility problem اللتي تكون عند السيدات بفعل
+
+917
+01:03:41,570 --> 01:03:44,550
+الأسباب اللتي تم ذكرها سواء كانت في الفيديو أو في
+
+918
+01:03:44,550 --> 01:03:48,680
+الشرحبهذا القدر نكتفي ونكون قد أنهينا من هذا ال
+
+919
+01:03:48,680 --> 01:03:51,520
+chapter على أمل أن نلتقي في محاضرة جديدة ب chapter
+
+920
+01:03:51,520 --> 01:03:55,560
+جديد ان شاء الله دومتم في حفظ الله و رعايته
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/LftGtVx2Jyc_raw.json b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/LftGtVx2Jyc_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..3abf81e4a73f8b55a0fcf87f92169857186d54ef
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/LftGtVx2Jyc_raw.json
@@ -0,0 +1 @@
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عملية ال collection عن طريق ال aspiration باستخدام needle معينة بجوج معينة تدخل من خلال ما يُعرف باسم ال Transvaginal aspiration هذه العملية ككل", "tokens": [10721, 3555, 25720, 6055, 33753, 45865, 15844, 9122, 13063, 2407, 8315, 2655, 10874, 11536, 18513, 35473, 32887, 21292, 1863, 8032, 13063, 2304, 11536, 23032, 3555, 3615, 995, 14111, 6225, 42213, 10632, 39894, 9381, 13546, 6225, 42213, 10632, 2423, 5765, 18871, 23032, 16572, 4587, 2423, 44565, 4724, 995, 14851, 9778, 3215, 10943, 11037, 20449, 9957, 3660, 4724, 7435, 29245, 20449, 9957, 3660, 6055, 3215, 9778, 1211, 9154, 16490, 1211, 6027, 19446, 7251, 10859, 3615, 28480, 4724, 32277, 2304, 2423, 6531, 42586, 2071, 44565, 29538, 18863, 42213, 10632, 9122, 28820], "avg_logprob": -0.23595505216148463, "compression_ratio": 1.6097560975609757, "no_speech_prob": 1.0728836059570312e-06, "words": [{"start": 227.1, "end": 227.64, "word": "أبرة", "probability": 0.5160319010416666}, {"start": 227.64, "end": 228.38, "word": " تحتوي", 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349.94, "word": " ال", "probability": 0.95751953125}, {"start": 349.94, "end": 350.34, "word": " fluid", "probability": 0.904296875}, {"start": 350.34, "end": 350.6, "word": " مع", "probability": 0.984375}, {"start": 350.6, "end": 350.72, "word": " ال", "probability": 0.97607421875}, {"start": 350.72, "end": 351.18, "word": " oocyte", "probability": 0.6941731770833334}, {"start": 351.18, "end": 351.46, "word": " سواء", "probability": 0.97412109375}, {"start": 351.46, "end": 351.78, "word": " كانت", "probability": 0.91162109375}, {"start": 351.78, "end": 352.18, "word": " mature", "probability": 0.9736328125}, {"start": 352.18, "end": 352.8, "word": " أو", "probability": 0.884765625}, {"start": 352.8, "end": 353.42, "word": " immature", "probability": 0.9482421875}, {"start": 353.42, "end": 354.14, "word": " لأن", "probability": 0.90185546875}, {"start": 354.14, "end": 354.28, "word": " ال", "probability": 0.87109375}, {"start": 354.28, "end": 354.64, "word": " immature", "probability": 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البوايدات الموجودة و أبدأ أعمل collection لهذه البوايدات و أنقلها من هذا ال fluid إلى a new media اللي اسمها maturation media أو IVF media", "tokens": [10721, 25957, 1211, 23874, 24976, 39184, 9113, 13672, 1829, 10874, 2304, 3615, 8978, 2423, 1500, 9917, 11203, 8592, 7649, 5551, 8592, 38688, 9122, 3215, 33599, 6225, 3215, 3215, 29739, 14407, 25708, 9307, 9673, 29245, 23328, 3660, 4032, 5551, 44510, 10721, 5551, 25957, 1211, 5765, 46740, 24192, 29739, 14407, 25708, 9307, 4032, 14739, 4587, 1211, 11296, 9154, 23758, 2423, 9113, 30731, 257, 777, 3021, 13672, 1829, 24525, 2304, 11296, 3803, 8167, 3021, 34051, 15967, 37, 3021], "avg_logprob": -0.13569079241470286, "compression_ratio": 1.5472636815920398, "no_speech_prob": 4.172325134277344e-07, "words": [{"start": 360.63, "end": 361.17, "word": "أعمل", "probability": 0.96728515625}, {"start": 361.17, "end": 361.81, "word": " examination", "probability": 0.77685546875}, {"start": 361.81, "end": 362.33, "word": " للـ", "probability": 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"temperature": 1.0}, {"id": 17, "seek": 39668, "start": 381.34, "end": 396.68, "text": "During the collection يجب أن يستخدم ضغط يقدر على أقصى حد مائة وعشرين ميلي متر ذئبقي هذا الضغط الموصفي خلال عملية الجمع وإلا زيادة الضغط بيعمل rupture في ال follicle", "tokens": [35, 1345, 264, 5765, 7251, 7435, 3555, 14739, 7251, 14851, 9778, 40448, 48812, 17082, 9566, 7251, 28543, 2288, 15844, 5551, 4587, 9381, 7578, 11331, 3215, 3714, 16373, 3660, 4032, 3615, 46309, 9957, 3714, 1829, 20292, 44650, 2288, 29910, 19986, 3555, 38436, 23758, 6024, 114, 17082, 9566, 9673, 2407, 9381, 41185, 16490, 1211, 6027, 6225, 42213, 10632, 25724, 2304, 3615, 4032, 28814, 15040, 30767, 1829, 18513, 3660, 6024, 114, 17082, 9566, 4724, 1829, 25957, 1211, 5420, 35603, 8978, 2423, 25483, 3520], "avg_logprob": -0.234375, "compression_ratio": 1.456043956043956, "no_speech_prob": 3.5762786865234375e-07, "words": [{"start": 381.34, "end": 381.78, "word": "During", "probability": 0.61248779296875}, {"start": 381.78, "end": 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"end": 406.59, "word": " plucida", "probability": 0.6063435872395834}, {"start": 406.59, "end": 407.55, "word": " بمعنى", "probability": 0.9208984375}, {"start": 407.55, "end": 408.01, "word": " آخر", "probability": 0.833740234375}, {"start": 408.01, "end": 408.39, "word": " إنه", "probability": 0.75537109375}, {"start": 408.39, "end": 408.67, "word": " مهم", "probability": 0.99267578125}, {"start": 408.67, "end": 409.09, "word": " جدا", "probability": 0.931640625}, {"start": 409.09, "end": 409.91, "word": " أستخدم", "probability": 0.915771484375}, {"start": 409.91, "end": 410.39, "word": " ضغط", "probability": 0.7137044270833334}, {"start": 410.39, "end": 410.91, "word": " يقدر", "probability": 0.9757486979166666}, {"start": 410.91, "end": 411.55, "word": " بـ120", "probability": 0.7482096354166666}, {"start": 411.55, "end": 411.99, "word": " ميلي", "probability": 0.541748046875}, {"start": 411.99, "end": 412.31, "word": " متر", "probability": 0.983642578125}, {"start": 412.31, "end": 412.83, "word": " ذئبقي", "probability": 0.8038330078125}, {"start": 412.83, "end": 413.61, "word": " خلال", "probability": 0.9754231770833334}, {"start": 413.61, "end": 414.27, "word": " عملية", "probability": 0.9860026041666666}, {"start": 414.27, "end": 414.93, "word": " الجمع", "probability": 0.7937825520833334}], "temperature": 1.0}, {"id": 19, "seek": 44494, "start": 415.38, "end": 444.94, "text": "ما أزيد هذا الضغط لأن زيادته ممكن تؤثر على ال oocyte بشكل سلبي وتدمرها أو تدمر ال cumulus الموجودة حوالي ال oocyte أو تدمر الزيونابليوسيدا ودمرت الزيونابليوسيدا يعني أنا فقط ال cytoplasm والمادة النووية once the oocyte are collected they are placed or put in culture plate with neutron media and then placed into incubator بمجرد ما أحصل على ال oocyte", "tokens": [15042, 5551, 11622, 25708, 23758, 6024, 114, 17082, 9566, 5296, 33456, 30767, 1829, 18513, 47395, 3714, 43020, 6055, 33604, 49115, 15844, 2423, 277, 31078, 975, 4724, 8592, 28820, 8608, 1211, 21292, 34683, 40448, 2288, 11296, 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aspiration و releasing سكشن و releasing هتروح كل هدوء يدل اللي باللون الأخضر الفاتح و هي الكيومولا السل لازم انا اتجنب كمية كبيرة جدا ال granulosa cell هي عبارة عن خليط من الموريلا cell و الكيومولا cell دعونا", "tokens": [9566, 3555, 3615, 995, 14111, 5296, 15042, 5551, 7435, 7578, 5551, 25957, 1211, 44565, 4032, 16327, 8608, 4117, 8592, 1863, 4032, 16327, 8032, 2655, 32887, 5016, 28242, 8032, 3215, 2407, 38207, 7251, 3215, 1211, 13672, 1829, 20666, 1211, 11536, 16247, 9778, 11242, 2288, 27188, 9307, 5016, 4032, 39896, 33251, 1829, 20498, 12610, 995, 21136, 1211, 5296, 31377, 2304, 1975, 8315, 1975, 2655, 7435, 1863, 3555, 9122, 2304, 10632, 9122, 3555, 48923, 10874, 28259, 2423, 9370, 425, 6447, 2815, 39896, 6225, 3555, 9640, 3660, 18871, 16490, 20292, 9566, 9154, 9673, 13063, 1829, 15040, 2815, 4032, 33251, 1829, 20498, 12610, 995, 2815, 11778, 3615, 2407, 8315], "avg_logprob": -0.26428571882702057, "compression_ratio": 1.6396396396396395, "no_speech_prob": 1.1920928955078125e-07, 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اكبر", "probability": 0.6827799479166666}, {"start": 2295.58, "end": 2296.32, "word": " البوايضات", "probability": 0.8396484375}, {"start": 2296.32, "end": 2298.4, "word": " هتشوفهم", "probability": 0.63662109375}, {"start": 2298.4, "end": 2299.54, "word": " بهذا", "probability": 0.91162109375}, {"start": 2299.54, "end": 2300.36, "word": " الشكل", "probability": 0.989013671875}, {"start": 2300.36, "end": 2300.98, "word": " هذه", "probability": 0.59130859375}, {"start": 2300.98, "end": 2301.44, "word": " فكرة", "probability": 0.9713541666666666}, {"start": 2301.44, "end": 2301.9, "word": " الـ", "probability": 0.708251953125}, {"start": 2301.9, "end": 2302.5, "word": " Denotation", "probability": 0.6463216145833334}, {"start": 2302.5, "end": 2303.16, "word": " بشكل", "probability": 0.9879557291666666}, {"start": 2303.16, "end": 2304.0, "word": " أساسي", "probability": 0.9649658203125}, {"start": 2304.0, "end": 2304.82, "word": " كيف", "probability": 0.9609375}, {"start": 2304.82, "end": 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"temperature": 1.0}, {"id": 87, "seek": 233462, "start": 2310.88, "end": 2334.62, "text": "الـ timing للـ oocyte denodation الـ oocyte denodation is usually performed between 37 and 40 hours after HCG يعني عملية الـ denodation بتصير بعد عملية ال injection للشريجون أو لل human chronic gonadotropin اللي بيعمل ovulation بـ 37 إلى 40 ساعة ولكن يجب أن تحدث", "tokens": [6027, 39184, 10822, 24976, 39184, 277, 31078, 975, 1441, 378, 399, 2423, 39184, 277, 31078, 975, 1441, 378, 399, 307, 2673, 10332, 1296, 13435, 293, 3356, 2496, 934, 30440, 38, 37495, 22653, 6225, 42213, 10632, 2423, 39184, 1441, 378, 399, 39894, 9381, 13546, 39182, 6225, 42213, 10632, 2423, 22873, 24976, 46309, 1829, 7435, 11536, 34051, 24976, 1952, 14493, 26307, 345, 310, 1513, 259, 13672, 1829, 4724, 1829, 25957, 1211, 14187, 2776, 4724, 39184, 13435, 30731, 3356, 8608, 995, 27884, 35525, 19452, 7251, 7435, 3555, 14739, 6055, 24401, 12984], "avg_logprob": -0.19733145665586665, "compression_ratio": 1.4572649572649572, 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{"start": 2323.16, "end": 2323.46, "word": " بعد", "probability": 0.95947265625}, {"start": 2323.46, "end": 2323.92, "word": " عملية", "probability": 0.9928385416666666}, {"start": 2323.92, "end": 2324.14, "word": " ال", "probability": 0.96142578125}, {"start": 2324.14, "end": 2324.54, "word": " injection", "probability": 0.923828125}, {"start": 2324.54, "end": 2325.44, "word": " للشريجون", "probability": 0.6725830078125}, {"start": 2325.44, "end": 2325.82, "word": " أو", "probability": 0.90966796875}, {"start": 2325.82, "end": 2326.08, "word": " لل", "probability": 0.76611328125}, {"start": 2326.08, "end": 2326.36, "word": " human", "probability": 0.73291015625}, {"start": 2326.36, "end": 2327.2, "word": " chronic", "probability": 0.58154296875}, {"start": 2327.2, "end": 2328.06, "word": " gonadotropin", "probability": 0.8900390625}, {"start": 2328.06, "end": 2328.6, "word": " اللي", "probability": 0.945556640625}, {"start": 2328.6, "end": 2328.94, "word": " بيعمل", "probability": 0.8564453125}, {"start": 2328.94, "end": 2329.56, "word": " ovulation", "probability": 0.904052734375}, {"start": 2329.56, "end": 2330.06, "word": " بـ", "probability": 0.707275390625}, {"start": 2330.06, "end": 2330.54, "word": " 37", "probability": 0.9599609375}, {"start": 2330.54, "end": 2331.04, "word": " إلى", "probability": 0.9580078125}, {"start": 2331.04, "end": 2331.46, "word": " 40", "probability": 0.98095703125}, {"start": 2331.46, "end": 2332.34, "word": " ساعة", "probability": 0.9322916666666666}, {"start": 2332.34, "end": 2333.34, "word": " ولكن", "probability": 0.860595703125}, {"start": 2333.34, "end": 2333.92, "word": " يجب", "probability": 0.9586588541666666}, {"start": 2333.92, "end": 2334.14, "word": " أن", "probability": 0.8759765625}, {"start": 2334.14, "end": 2334.62, "word": " تحدث", "probability": 0.9905598958333334}], "temperature": 1.0}, {"id": 88, "seek": 236407, "start": 2334.87, "end": 2364.07, "text": "قبل الـ insemination بساعة أو نص ساعة على الأقل الإنزيمات التي تستخدم وتركيزها بشكل عام وtraditionally الـdenodation أو الـ denoding process أو procedure involve a poivrein derivative هيلورينيدازي يعني هيلورينيدازي مع مشتق من الـpoivrein بشكل أساسي in order to minimum any potential toxic effect on oocyte for this type of enzyme", "tokens": [4587, 36150, 2423, 39184, 33874, 2367, 399, 4724, 3794, 995, 27884, 34051, 8717, 9381, 8608, 995, 27884, 15844, 16247, 4587, 1211, 33688, 1863, 11622, 32640, 9307, 38392, 6055, 14851, 9778, 40448, 34683, 31747, 1829, 11622, 11296, 4724, 8592, 28820, 6225, 10943, 4032, 43831, 15899, 2423, 39184, 1556, 378, 399, 34051, 2423, 39184, 1441, 8616, 1399, 34051, 10747, 9494, 257, 714, 592, 265, 259, 13760, 39896, 1211, 13063, 9957, 25708, 31377, 1829, 37495, 22653, 39896, 1211, 13063, 9957, 25708, 31377, 1829, 20449, 37893, 2655, 4587, 9154, 2423, 39184, 2259, 592, 265, 259, 4724, 8592, 28820, 5551, 3794, 32277, 1829, 294, 1668, 281, 7285, 604, 3995, 12786, 1802, 322, 277, 31078, 975, 337, 341, 2010, 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{"start": 2339.49, "end": 2339.69, "word": " التي", "probability": 0.86181640625}, {"start": 2339.69, "end": 2340.25, "word": " تستخدم", "probability": 0.9691162109375}, {"start": 2340.25, "end": 2341.01, "word": " وتركيزها", "probability": 0.97099609375}, {"start": 2341.01, "end": 2341.49, "word": " بشكل", "probability": 0.9708658854166666}, {"start": 2341.49, "end": 2341.87, "word": " عام", "probability": 0.998779296875}, {"start": 2341.87, "end": 2343.05, "word": " وtraditionally", "probability": 0.6263834635416666}, {"start": 2343.05, "end": 2344.37, "word": " الـdenodation", "probability": 0.668359375}, {"start": 2344.37, "end": 2344.67, "word": " أو", "probability": 0.83740234375}, {"start": 2344.67, "end": 2344.73, "word": " الـ", "probability": 0.738037109375}, {"start": 2344.73, "end": 2345.17, "word": " denoding", "probability": 0.557373046875}, {"start": 2345.17, "end": 2346.49, "word": " process", "probability": 0.97216796875}, {"start": 2346.49, "end": 2347.47, "word": " أو", "probability": 0.84814453125}, {"start": 2347.47, "end": 2347.99, "word": " procedure", "probability": 0.462158203125}, {"start": 2347.99, "end": 2348.71, "word": " involve", "probability": 0.385498046875}, {"start": 2348.71, "end": 2349.05, "word": " a", "probability": 0.7822265625}, {"start": 2349.05, "end": 2349.65, "word": " poivrein", "probability": 0.4620361328125}, {"start": 2349.65, "end": 2350.43, "word": " derivative", "probability": 0.841796875}, {"start": 2350.43, "end": 2352.25, "word": " هيلورينيدازي", "probability": 0.5640869140625}, {"start": 2352.25, "end": 2352.51, "word": " يعني", "probability": 0.86083984375}, {"start": 2352.51, "end": 2354.67, "word": " هيلورينيدازي", "probability": 0.8366350446428571}, {"start": 2354.67, "end": 2354.95, "word": " مع", "probability": 0.57763671875}, {"start": 2354.95, "end": 2355.61, "word": " مشتق", "probability": 0.9044596354166666}, {"start": 2355.61, "end": 2355.89, "word": " من", "probability": 0.9853515625}, {"start": 2355.89, "end": 2356.73, "word": " الـpoivrein", "probability": 0.776123046875}, {"start": 2356.73, "end": 2357.15, "word": " بشكل", "probability": 0.9767252604166666}, {"start": 2357.15, "end": 2358.25, "word": " أساسي", "probability": 0.981689453125}, {"start": 2358.25, "end": 2358.85, "word": " in", "probability": 0.857421875}, {"start": 2358.85, "end": 2359.19, "word": " order", "probability": 0.9453125}, {"start": 2359.19, "end": 2359.49, "word": " to", "probability": 0.97705078125}, {"start": 2359.49, "end": 2359.83, "word": " minimum", "probability": 0.6875}, {"start": 2359.83, "end": 2360.19, "word": " any", "probability": 0.86279296875}, {"start": 2360.19, "end": 2360.79, "word": " potential", "probability": 0.880859375}, {"start": 2360.79, "end": 2361.39, "word": " toxic", "probability": 0.95458984375}, {"start": 2361.39, "end": 2361.91, "word": " effect", "probability": 0.8955078125}, {"start": 2361.91, "end": 2362.33, "word": " on", "probability": 0.91455078125}, {"start": 2362.33, "end": 2362.89, "word": " oocyte", "probability": 0.8416341145833334}, {"start": 2362.89, "end": 2363.13, "word": " for", "probability": 0.9013671875}, {"start": 2363.13, "end": 2363.35, "word": " this", "probability": 0.95849609375}, {"start": 2363.35, "end": 2363.59, "word": " type", "probability": 0.95947265625}, {"start": 2363.59, "end": 2363.73, "word": " of", "probability": 0.96337890625}, {"start": 2363.73, "end": 2364.07, "word": " enzyme", "probability": 0.955078125}], "temperature": 1.0}, {"id": 89, "seek": 239290, "start": 2364.56, "end": 2392.9, "text": "we should be reduce the enzymatic concentration or the enzyme concentration or reduce that duration for oocyte exposure to this type of enzyme يعني أنا ممكن أجلل ال toxicity الخاصة بهذا الانزيم بطريقة تانية الطريقة الأولى أنه أجلل ال time اللي بتتعرض فيه الخلية لهذا الانزيم أو أجلل ما يُعرف باسم ال concentration الخاصة فيه وفي بعضهم بيجلد ال time أفضل لإن ال concentration بيكون fixed", "tokens": [826, 820, 312, 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so we can use a match as a predictor for ovarian reserve and ovarian response سوف نكتفي بهذا القدر في المحاضرة اليوم على أن نكمل ما تبقى من هذا ال chapter في المحاضرة القادمة ان شاء الله", "tokens": [7035, 312, 1143, 382, 16961, 337, 277, 8517, 952, 4134, 293, 277, 8517, 952, 17824, 15844, 3714, 9778, 11622, 11536, 9673, 21292, 11242, 4032, 2304, 3215, 7578, 44713, 7435, 16758, 3660, 9673, 21292, 11242, 370, 321, 393, 764, 257, 2995, 382, 257, 6069, 284, 337, 277, 8517, 952, 17824, 293, 277, 8517, 952, 4134, 8608, 38688, 8717, 4117, 2655, 41185, 39627, 15730, 25062, 3215, 2288, 8978, 9673, 5016, 46958, 25720, 45595, 20498, 15844, 14739, 8717, 24793, 1211, 19446, 6055, 3555, 4587, 7578, 9154, 23758, 2423, 7187, 8978, 9673, 5016, 46958, 25720, 25062, 18513, 46007, 16472, 13412, 16606, 21984], "avg_logprob": -0.1470959632083623, "compression_ratio": 1.7391304347826086, "no_speech_prob": 1.7881393432617188e-06, "words": [{"start": 2725.26, "end": 2725.52, "word": "can", "probability": 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/LftGtVx2Jyc_raw.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/LftGtVx2Jyc_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b1a31a1a4343ddf0674350f90b00e5a3f7bec3d8
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/LftGtVx2Jyc_raw.srt
@@ -0,0 +1,2388 @@
+1
+00:00:00,930 --> 00:00:05,210
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:05,210 --> 00:00:11,650
+المرسلين سيدنا محمد وعلى آله وصحبه أجمعين طلبنا
+
+3
+00:00:11,650 --> 00:00:16,070
+الأكارم نرجو من الله الكريم أن تكونوا جميعا بخير
+
+4
+00:00:16,070 --> 00:00:21,810
+وبصحة جيدة اليوم سوف نستكمل ما تقطع من الشبط
+
+5
+00:00:21,810 --> 00:00:26,880
+الرابعحيث تحدثنا في المحاضرات السابقة عن القالية
+
+6
+00:00:26,880 --> 00:00:31,600
+والنظام المتبع من أجل تحفيز المبيض للسيدة التي
+
+7
+00:00:31,600 --> 00:00:35,780
+تخضع لعمليات التلقيح الصناعي أو الزراعة من أجل
+
+8
+00:00:35,780 --> 00:00:40,500
+الحصول على أكبر عدد من البويضات الناضجة وذات
+
+9
+00:00:40,500 --> 00:00:45,520
+الجودة العالية وقُسمت هذه الأنظمة المستخدمة إلى
+
+10
+00:00:45,520 --> 00:00:50,020
+Agonist Protocol وAntagonist Protocolالـ Agonist
+
+11
+00:00:50,020 --> 00:00:54,100
+Protocol على سبيل المثال قُسم إلى Ultra Short و
+
+12
+00:00:54,100 --> 00:00:59,300
+Short و Long والـ Antagonist Protocol قُسم إلى One
+
+13
+00:00:59,300 --> 00:01:04,000
+Dose أو Single Dose أو Multi Doseأدى بالنسبة إلى
+
+14
+00:01:04,000 --> 00:01:08,380
+ما تحدثنا عنه في المحاضرة السابقة ثم انتقلنا
+
+15
+00:01:08,380 --> 00:01:13,160
+للتحدث عن حالة مرضية تسمى Hyperovarian Stimulation
+
+16
+00:01:13,160 --> 00:01:17,700
+Syndrome والتي تحدث عند بعض السيدات بسبب الإفراط
+
+17
+00:01:17,700 --> 00:01:22,740
+في عملية إعطاء الأدوية التي تعمل على تحفيظ المبيض
+
+18
+00:01:22,740 --> 00:01:27,920
+مما يؤدي إلى إنتاج بويضات غير ناضجة أو الوصول إلى
+
+19
+00:01:27,920 --> 00:01:35,050
+فوليكل ناضق تحتوي علىfluid بدون أي mature oocyte
+
+20
+00:01:35,050 --> 00:01:40,270
+اليوم سوف نتكلم عن المرحلة الثانية من مراحل تحضير
+
+21
+00:01:40,270 --> 00:01:46,090
+السيدة فبعد إعطاء السيدة هرمون الـHCG لـHuman
+
+22
+00:01:46,090 --> 00:01:50,710
+Chronic Gynadotropin الذي يعمل عمل الـLH من أجل
+
+23
+00:01:50,710 --> 00:01:56,280
+عمل ovulationيجب أن نلتقي وننتقل إلى نقطة جديدة
+
+24
+00:01:56,280 --> 00:02:04,060
+اسمها or oocyte pick up بمعنى
+
+25
+00:02:04,060 --> 00:02:08,860
+آخر عملية الحصاد عملية ال harvest بعد ما تم تحفيز
+
+26
+00:02:08,860 --> 00:02:14,900
+المبيع و اتصل فولكل بعدد معين و بعدد مناسب إلى
+
+27
+00:02:14,900 --> 00:02:20,680
+ديامتر مناسب أكبر من أو يساوي 18 ملي مترمعناه إن
+
+28
+00:02:20,680 --> 00:02:25,560
+هذه الفوليكل تحتوي على بويضة ناضجة تكون صالحة
+
+29
+00:02:25,560 --> 00:02:30,220
+للطلقيح الصناعي إذا كانت متوقفة في الـ Metaphase 2
+
+30
+00:02:30,220 --> 00:02:35,300
+Metaphase التاني يعني الـ Metaphase الخاص بالقسام
+
+31
+00:02:35,300 --> 00:02:38,920
+الميوزي الثاني والذي يدل على هذا الأمر وجود الـ
+
+32
+00:02:38,920 --> 00:02:42,600
+Ferrous Polar Body ننتقل إلى مرحلة جديدة وهي مرحلة
+
+33
+00:02:42,600 --> 00:02:47,560
+الـ Collection أو الـ Oocyte Retrieval أو الـ Ovum
+
+34
+00:02:47,560 --> 00:02:53,180
+Pick Upبمعنى آخر إن كل follicle وصلت إلى الـ
+
+35
+00:02:53,180 --> 00:02:57,900
+maturation stage المفروض تحتوي على بويضة ناتجة
+
+36
+00:02:57,900 --> 00:03:02,780
+المفروض بعد إعطاء الكورونادوتروبين administration
+
+37
+00:03:02,780 --> 00:03:08,260
+نستطيع هذه الـ follicle أن تقوم بعملية ovulation
+
+38
+00:03:08,260 --> 00:03:12,520
+ليه بتضبط بعد الكورونادوتروبين؟ لأن هذا الهرمون
+
+39
+00:03:12,520 --> 00:03:18,280
+مسئول عن عمل الألأتش أو عمله يحاكي عمل الألأتشوهي
+
+40
+00:03:18,280 --> 00:03:23,000
+عبارة عن عملية الـ ovulation and oocyte pickup is
+
+41
+00:03:23,000 --> 00:03:27,460
+performed approximately 36 hours later by
+
+42
+00:03:27,460 --> 00:03:31,940
+ultrasound transvaginal aspiration بمعنى آخر إن
+
+43
+00:03:31,940 --> 00:03:37,680
+عملية جمع البويضات تحدث بعد 36 ساعة من إعطاء إبرة
+
+44
+00:03:37,680 --> 00:03:42,000
+التفجير اللي بنسميها بالوضع العام بإبرة التفجير أو
+
+45
+00:03:42,000 --> 00:03:46,500
+sheregon يعني إبرة التفجير إبرة الشيرجون وهي عبارة
+
+46
+00:03:46,500 --> 00:03:52,320
+عنأبرة تحتوي على كورونات جونادوتروبين هورمون طبعاً
+
+47
+00:03:52,320 --> 00:03:55,820
+عملية بتصير عملية ال collection عن طريق ال
+
+48
+00:03:55,820 --> 00:04:00,080
+aspiration باستخدام needle معينة بجوج معينة تدخل
+
+49
+00:04:00,080 --> 00:04:03,500
+من خلال ما يُعرف باسم ال Transvaginal aspiration
+
+50
+00:04:03,500 --> 00:04:09,240
+هذه العملية ككلفي لحظة عمل الـ Oocyte Collection
+
+51
+00:04:09,240 --> 00:04:12,980
+لازم نعمل Clearing للفاجينة بالـ Normal Saline
+
+52
+00:04:12,980 --> 00:04:18,440
+بدون استخدام أي مطهر على سبيل المثال الـ Betadine
+
+53
+00:04:18,440 --> 00:04:24,040
+لا يمكن ولا ينصح باستخدامه كنوع من أنواع المطهرات
+
+54
+00:04:24,040 --> 00:04:28,900
+قبل عملية الـ Egg Collectionلأنه very toxic وممكن
+
+55
+00:04:28,900 --> 00:04:33,920
+يؤثر على ال egg بشكل سلبي وبشكل غير مرغوب فيه
+
+56
+00:04:33,920 --> 00:04:37,500
+عملية جمع البويضات تسمى ال oocyte pick up أو ال
+
+57
+00:04:37,500 --> 00:04:41,820
+oocyte harvest أو harvest the harvesting is
+
+58
+00:04:41,820 --> 00:04:45,660
+carried out using the aspiration unit composed of
+
+59
+00:04:45,660 --> 00:04:50,260
+vacuum pumpA collection tube connected to 70 gauge
+
+60
+00:04:50,260 --> 00:04:53,840
+needle and collection test tube يعني الوحدة
+
+61
+00:04:53,840 --> 00:04:57,720
+المسؤولة عن عملية جمع البويضات تتكون من تلت مكونات
+
+62
+00:04:57,720 --> 00:05:02,020
+أساسية المكون الأول هو ال vacuum pump مضخة تعتمد
+
+63
+00:05:02,020 --> 00:05:08,590
+علىالـ suction سحب الأواء الشغلة التانية و سحب الـ
+
+64
+00:05:08,590 --> 00:05:11,710
+fluid الشغلة التانية الـ collection tube متصلة
+
+65
+00:05:11,710 --> 00:05:16,910
+بنيدل الجوج تبعها 17 بالإضافة إلى collection test
+
+66
+00:05:16,910 --> 00:05:20,590
+tube وهي الـ test tube التي تجمع بها البوايضات هذه
+
+67
+00:05:20,590 --> 00:05:25,750
+عبارة عن الـ oocyte collection unit تلت مكونات
+
+68
+00:05:25,750 --> 00:05:30,910
+vacuum pump collection tube متصلة بالجوج نيدل 17 و
+
+69
+00:05:30,910 --> 00:05:35,160
+collection test tubeالـ fluid الموجود داخل الـ
+
+70
+00:05:35,160 --> 00:05:39,100
+follicle يجب أن يُسحب كله ويجب أن يُسحب من كل
+
+71
+00:05:39,100 --> 00:05:43,400
+follicle وصلت إلى 18 mm على الأقل سواء كان في الـ
+
+72
+00:05:43,400 --> 00:05:46,960
+over اليمين أو في ال over اليسار فبالتالي أنا أسحب
+
+73
+00:05:46,960 --> 00:05:50,720
+كل fluid الموجود معناه أنا بسحب ال fluid مع ال
+
+74
+00:05:50,720 --> 00:05:54,280
+oocyte سواء كانت mature أو immature لأن ال
+
+75
+00:05:54,280 --> 00:05:59,400
+immature في خارج جسم الإنسان لها استخدامات شتة بعد
+
+76
+00:05:59,400 --> 00:06:03,310
+كده ببدأأعمل examination للـ fluid اللي جمع في ال
+
+77
+00:06:03,310 --> 00:06:07,790
+test tube علشان أشوف كداش عدد البوايدات الموجودة و
+
+78
+00:06:07,790 --> 00:06:10,710
+أبدأ أعمل collection لهذه البوايدات و أنقلها من
+
+79
+00:06:10,710 --> 00:06:16,150
+هذا ال fluid إلى a new media اللي اسمها maturation
+
+80
+00:06:16,150 --> 00:06:23,800
+media أو IVF mediaDuring the collection يجب أن
+
+81
+00:06:23,800 --> 00:06:28,740
+يستخدم ضغط يقدر على أقصى حد مائة وعشرين ميلي متر
+
+82
+00:06:28,740 --> 00:06:34,080
+ذئبقي هذا الضغط الموصفي خلال عملية الجمع وإلا
+
+83
+00:06:34,080 --> 00:06:37,670
+زيادة الضغط بيعمل rupture في ال follicleوهذا شيء
+
+84
+00:06:37,670 --> 00:06:41,950
+غير مطلوب to avoid the risk of damage of oocyte
+
+85
+00:06:41,950 --> 00:06:45,990
+such as stripping the cumulus cell or the zona
+
+86
+00:06:45,990 --> 00:06:50,910
+plucida بمعنى آخر إنه مهم جدا أستخدم ضغط يقدر
+
+87
+00:06:50,910 --> 00:06:56,400
+بـ120 ميلي متر ذئبقي خلال عملية الجمعما أزيد هذا
+
+88
+00:06:56,400 --> 00:07:00,280
+الضغط لأن زيادته ممكن تؤثر على ال oocyte بشكل سلبي
+
+89
+00:07:00,280 --> 00:07:04,660
+وتدمرها أو تدمر ال cumulus الموجودة حوالي ال
+
+90
+00:07:04,660 --> 00:07:07,700
+oocyte أو تدمر الزيونابليوسيدا ودمرت
+
+91
+00:07:07,700 --> 00:07:10,440
+الزيونابليوسيدا يعني أنا فقط ال cytoplasm والمادة
+
+92
+00:07:10,440 --> 00:07:14,980
+النووية once the oocyte are collected they are
+
+93
+00:07:14,980 --> 00:07:19,320
+placed or put in culture plate with neutron media
+
+94
+00:07:19,320 --> 00:07:24,060
+and then placed into incubator بمجرد ما أحصل على
+
+95
+00:07:24,060 --> 00:07:28,050
+ال oocyteالـ fluid اللي جمعته من الـ follicle و
+
+96
+00:07:28,050 --> 00:07:31,130
+ابتدأ أعمل examination تحت ال inverted microscope
+
+97
+00:07:31,130 --> 00:07:34,910
+و أجمع البويضات هذه البويضات باخدها ب sterile
+
+98
+00:07:34,910 --> 00:07:38,830
+dropper و بنجلها على طبق يحتوي على قطرات من ال
+
+99
+00:07:38,830 --> 00:07:43,630
+media المغذية و بنقل هذا الطبق و بوضعه في ال
+
+100
+00:07:43,630 --> 00:07:49,210
+incubator بقولي ببساطة جدا هذه العملية كلها تحدث
+
+101
+00:07:49,210 --> 00:07:54,100
+عملية ال oocyte collection تحت تخدير موضعيأو تخدير
+
+102
+00:07:54,100 --> 00:07:58,080
+كلي ولكن خفيف لفترة زمانية قصيرة الفترة الزمانية
+
+103
+00:07:58,080 --> 00:08:00,840
+المفروض تاخدها العملية كلها عملية ال egg
+
+104
+00:08:00,840 --> 00:08:04,340
+collection و ال fluid aspiration من 10 إلى 15
+
+105
+00:08:04,340 --> 00:08:09,020
+دقيقة و الطبيب الشاطر ما بتطلق blood في ال fluid
+
+106
+00:08:09,020 --> 00:08:14,640
+المسحوب من ال follicle Therefore, during a system
+
+107
+00:08:14,640 --> 00:08:17,080
+reproductive technology procedure, cumulus cells
+
+108
+00:08:17,080 --> 00:08:19,440
+surrounding the oocyte should be removed to
+
+109
+00:08:19,440 --> 00:08:23,120
+improve oocyte evaluation and manipulationهنعرف
+
+110
+00:08:23,120 --> 00:08:26,500
+إيش يعني cumulus cell واتكلمنا عنها cumulus cell
+
+111
+00:08:26,500 --> 00:08:29,900
+فيما سبق إنه في خلايا خفيفة موجودة حول ال oocyte
+
+112
+00:08:29,900 --> 00:08:33,200
+تسمى cumulus cell هذه ال cumulus cell لازم أخفف
+
+113
+00:08:33,200 --> 00:08:37,120
+عددها بشكل كبير جدا أو أزينها علشان يسهل عملية
+
+114
+00:08:37,120 --> 00:08:42,380
+evaluation لل oocyte وأحدد هل هي mature ولا
+
+115
+00:08:42,380 --> 00:08:45,460
+immature ويسهل عملية ال manipulation وما المقصود
+
+116
+00:08:45,460 --> 00:08:50,060
+فيها ال injection مهم جداأعرّ الخلية، أخفف عدد الـ
+
+117
+00:08:50,060 --> 00:08:52,920
+Cumulus Cell اللي حوالها، أزيل الـ Cumulus Cell
+
+118
+00:08:52,920 --> 00:08:59,500
+اللي حوالها بعض الأحيان بكون عندى بويضات أو بكون
+
+119
+00:08:59,500 --> 00:09:03,800
+عندى Full Hill وصلت للـ18 مليمتر ولكن البويضات لم
+
+120
+00:09:03,800 --> 00:09:07,450
+تصل إلى درجة النضوجةفبطّر في هذه الحلقة أعملها
+
+121
+00:09:07,450 --> 00:09:11,710
+maturation outside in vitro maturation تحت مصطلح
+
+122
+00:09:11,710 --> 00:09:15,670
+oocyte maturation في ال clinical IVF laboratories
+
+123
+00:09:15,670 --> 00:09:21,090
+التكنولوجيست اللي بيشتغلوا في هذا المجال بيميلوا
+
+124
+00:09:21,090 --> 00:09:25,890
+إلى استغلال البويضات الغير ناضجة وانضاجها في
+
+125
+00:09:25,890 --> 00:09:31,470
+المختبر ثم استخدامها في عملية الحقد من أجل زيادة
+
+126
+00:09:31,470 --> 00:09:36,740
+عدد البويضات المحقونة مما يؤدي لزيادة معدلالحقن أو
+
+127
+00:09:36,740 --> 00:09:40,200
+معدل ال fertilization وخدوا بالك بعض البويضات اللي
+
+128
+00:09:40,200 --> 00:09:44,060
+بالشكل هذا بتنجح و بتعطيني embryo و البعض لا ينجح
+
+129
+00:09:44,060 --> 00:09:47,780
+ولا يعطي embryo في بعض البويضات في بتكون في مرحلة
+
+130
+00:09:47,780 --> 00:09:54,000
+ال GV وهي التي تسمى germinal vesicle وفي مرحلة ال
+
+131
+00:09:54,000 --> 00:09:59,600
+M1 وهي القسم الميوز الأولوفي الـ M2 القسم الميوزي
+
+132
+00:09:59,600 --> 00:10:05,680
+التاني فبالتالي myotic maturation actually is a
+
+133
+00:10:05,680 --> 00:10:08,740
+continuous process and some oocyte aspirated from
+
+134
+00:10:08,740 --> 00:10:14,000
+follicle of various size would be expected to be
+
+135
+00:10:14,000 --> 00:10:16,560
+intermediate stage of maturation يعني في بعض
+
+136
+00:10:16,560 --> 00:10:20,060
+الأحيان بيصير في عندي بعض ال follicle تحتوي على
+
+137
+00:10:20,060 --> 00:10:26,420
+بويضات أنا بسحب هذه ال fluid وبما فيها منبوايضات
+
+138
+00:10:26,420 --> 00:10:30,700
+ولكن بلاج البوايضات غير ناضجة أو وكفت في أحد ال
+
+139
+00:10:30,700 --> 00:10:34,560
+stage الذي يُعتبر intermediate stage خلال عملية ال
+
+140
+00:10:34,560 --> 00:10:39,640
+maturation من أشهر هذه البوايضات زي ما حكينا هي ال
+
+141
+00:10:39,640 --> 00:10:43,840
+GV من أشهر هذه البوايضات التي تُعتبر إما pure
+
+142
+00:10:43,840 --> 00:10:48,240
+oocyte هي ال GV وهي ال germinal vesicle و ال
+
+143
+00:10:48,240 --> 00:10:53,120
+metaphase I إذن أنا عندي أربع .. تلت أقسام
+
+144
+00:10:53,120 --> 00:11:00,080
+للبوايضة ممكن أحصل عليهاإما GV أو M1 أو M2 M2
+
+145
+00:11:00,080 --> 00:11:05,400
+معناه إن البويضة وقفت في انقسام الميوز الثاني في
+
+146
+00:11:05,400 --> 00:11:10,440
+الـ Stage Metaphyse فهي صالحة للحقن الـ GV الـ
+
+147
+00:11:10,440 --> 00:11:14,660
+Germinal Vesicle و الـ M1 يعني انقسام الميوز الأول
+
+148
+00:11:14,660 --> 00:11:18,100
+في الـ Metaphyse الأول أو انقسام الميوز الأول
+
+149
+00:11:18,100 --> 00:11:23,280
+معناه هذه البويضات إما pure oocyte تكون غير صالحة
+
+150
+00:11:23,280 --> 00:11:28,810
+للحقن إلا بعضبعد الإنضاج ومش كلهم بيصلوا لل level
+
+151
+00:11:28,810 --> 00:11:32,210
+الخاص بال maturation break down of germinal
+
+152
+00:11:32,210 --> 00:11:39,050
+vesicle indicates the continuance of meiosis and
+
+153
+00:11:39,050 --> 00:11:42,590
+ejaculate of the first polar body indicates
+
+154
+00:11:42,590 --> 00:11:45,250
+complete the first meiotic division in human
+
+155
+00:11:45,250 --> 00:11:49,130
+oocyte عشان أقول والله الخلية أو الويضة التي
+
+156
+00:11:49,130 --> 00:11:53,480
+سُحِبت وهي في مرحلة ال GV ال germinal vesicleلازم
+
+157
+00:11:53,480 --> 00:11:58,060
+أوضعها في ظروف تشبه الظروف الموجودة داخل الـ Opera
+
+158
+00:11:58,060 --> 00:12:01,480
+الخاصة بالسيدة يعني في ظروف شبه طبيعية في media
+
+159
+00:12:01,480 --> 00:12:06,280
+تحاكي الظرفة التي تعيش فيها البوايدة عشان أسمح لها
+
+160
+00:12:06,280 --> 00:12:11,960
+بالنضوج والدليل على نضوجها أو تحويلها من GV إلى
+
+161
+00:12:11,960 --> 00:12:19,240
+مثلا M2 تكون عند إذن صالح للحقل أنه يزيد حجمها
+
+162
+00:12:19,730 --> 00:12:24,290
+وتقضف ال first polar body الخاص بها للخارج فبتطيني
+
+163
+00:12:24,290 --> 00:12:30,210
+خلية أو بويضة اسمها بويضة ناضجة في مرحلة ال M2 عند
+
+164
+00:12:30,210 --> 00:12:34,110
+هذا اللحظة أو عند تلك اللحظة تكون صالحة للإخصام
+
+165
+00:12:34,110 --> 00:12:40,630
+اذا تلت حالات البويضة تلخيص الحدث GV M1 M2 هذه
+
+166
+00:12:40,630 --> 00:12:44,390
+حالات البويضة التي يمكن أنراها ال M2 تكون هي
+
+167
+00:12:44,390 --> 00:12:49,030
+الوحيدة الصالحة لعملية الإخصادالـ GV هي عبارة عن
+
+168
+00:12:49,030 --> 00:12:54,150
+خلية غير ناضجة والـ M1 خلية غير ناضجة أيضًا يمكن
+
+169
+00:12:54,150 --> 00:12:59,350
+أن تنضج في المختبر صورة توضح الكلام اللي احنا
+
+170
+00:12:59,350 --> 00:13:05,170
+حكيناه عن طبيعة انقسام البويضة هي في عندي الـ GV
+
+171
+00:13:05,170 --> 00:13:11,190
+الخاص بالبويضة على سبيل المثال هذه GV وهي عبارة عن
+
+172
+00:13:11,190 --> 00:13:15,970
+German Visicleوهي عند ال M1 وهي عبارة عن البويضة
+
+173
+00:13:15,970 --> 00:13:18,770
+اللتي وقفت في أحد الستجل خاصة بالانقسام الميوزي
+
+174
+00:13:18,770 --> 00:13:25,590
+الأول وهي M2 وهي عبارة عن البويضة البويضة دخلت
+
+175
+00:13:25,590 --> 00:13:32,570
+وأنهت الانقسام الميوزي الأول واتوقفت في الانقسام
+
+176
+00:13:32,570 --> 00:13:37,110
+الميوزي التاني في مرحلة ال meta phase مما أدى إلى
+
+177
+00:13:37,110 --> 00:13:43,730
+ظهور ال fairest polar bodyبعد ال maturation و ال
+
+178
+00:13:43,730 --> 00:13:48,450
+fertilization يظهر ال second polar body لأنه حكينا
+
+179
+00:13:48,450 --> 00:13:52,530
+أن ال first polar body هو أول indication على أن
+
+180
+00:13:52,530 --> 00:13:57,150
+البويضة أنهت الانقسام الميوز الأول و أنهت جزء كبير
+
+181
+00:13:57,150 --> 00:14:01,470
+من انقسام الميوز التاني و توقفت في ال stage الاسم
+
+182
+00:14:01,470 --> 00:14:06,850
+ميتا فيز 2 يعني الميتا فيز التاني من انقسام التاني
+
+183
+00:14:06,850 --> 00:14:10,440
+او الميتا فيز الخاص بالانقسام الميوز التانيأما
+
+184
+00:14:10,440 --> 00:14:13,160
+بالنسبة إلى الـ two polar body أو الـ second polar
+
+185
+00:14:13,160 --> 00:14:19,040
+body لا يظهر إلا بعد عملية ونجاح عملية ال
+
+186
+00:14:19,040 --> 00:14:23,800
+fertilization تلقيح البويضة من خلال وجود ال spirit
+
+187
+00:14:23,800 --> 00:14:31,060
+هذه عبارة عن مراحل البويضة بشكل الكامل طيب the
+
+188
+00:14:31,060 --> 00:14:34,520
+immature oocyte are incubated in the original
+
+189
+00:14:34,870 --> 00:14:38,570
+Culture Media or Original Tissue Culture Dish
+
+190
+00:14:38,570 --> 00:14:42,570
+بتكون من واحد أو يحتوي على واحد مليمتر من الـ
+
+191
+00:14:42,570 --> 00:14:45,670
+Oocyte Maturation Media يعني الميديا المستخدمة
+
+192
+00:14:45,670 --> 00:14:50,370
+لتطوير ونضوج الـ Oocyte حيث تحتوي هذه الميديا على
+
+193
+00:14:50,370 --> 00:14:55,630
+75 ملل International Unit لكل مليلتر من الـ FSH
+
+194
+00:14:55,630 --> 00:15:00,530
+بالإضافة إلى 75 من الـ LH وموجودة في إنكبياتور 37
+
+195
+00:15:00,530 --> 00:15:05,730
+درجة مئوية يعني كل هذه الميدياهي مواد مغذية ودرجة
+
+196
+00:15:05,730 --> 00:15:09,570
+حرارة مناسبة بالإضافة إلى هرمونات الأفاساتش
+
+197
+00:15:09,570 --> 00:15:14,910
+والألاتش المستخدمان في إنضاج البوايدة طبعا بوضعوها
+
+198
+00:15:14,910 --> 00:15:20,630
+في إنكبياتور على 37 درجة مئوية في وجود 5% carbon
+
+199
+00:15:20,630 --> 00:15:27,050
+dioxide و95% air with high humidity ويجب أن تكون
+
+200
+00:15:27,050 --> 00:15:31,110
+في نسبة عالية من الرطوبة طبعا يفضل إنها تحضن
+
+201
+00:15:31,110 --> 00:15:35,570
+البوايدة الغير نادجة لكي تنضجفي وجود انكبياتور فيه
+
+202
+00:15:35,570 --> 00:15:39,410
+triple gas نيتروجين كاربون دايفسايد اكسيجين
+
+203
+00:15:39,410 --> 00:15:45,570
+النيتروجين يوصف 90% الثريفستر كاربون 5% والأكسيجن
+
+204
+00:15:45,570 --> 00:15:50,870
+5% و ال humidity الرطوبة 100% عشان كده لإما بيكون
+
+205
+00:15:50,870 --> 00:15:55,190
+في عندي normal saline bottle معلقة في الانكبياتور
+
+206
+00:15:55,190 --> 00:15:59,250
+من الخارج موصلة بأنبوب لداخل الانكبياتور عشان توفر
+
+207
+00:15:59,800 --> 00:16:03,820
+الرطوبة المناسبة أو بيضعوا يعني زي حاوية بسيطة
+
+208
+00:16:03,820 --> 00:16:06,980
+فيها ديستل ووتر أو ultra pure water داخل ال
+
+209
+00:16:06,980 --> 00:16:10,900
+incubator علشان في درجة حرارة 37 بتتبخر الماء
+
+210
+00:16:10,900 --> 00:16:15,880
+فبتكونلي كمية مناسبة ودرجة مناسبة من الرطوبة التي
+
+211
+00:16:15,880 --> 00:16:20,820
+تبقي البوايدة في حالة جيدة جدا ال oocyte
+
+212
+00:16:20,820 --> 00:16:26,220
+maturation media should be preparedبنسبة .. طبعا
+
+213
+00:16:26,220 --> 00:16:30,740
+ال media التي تستخدم لإنضاج ال oocyte يجب أن تحضر
+
+214
+00:16:30,740 --> 00:16:35,360
+قبل ساعتين من وضع البويضة الغير نادجة ويفضل أن
+
+215
+00:16:35,360 --> 00:16:40,040
+تحضر قبل بيوم يعني بنحضرها و بنحط لها drops أو
+
+216
+00:16:40,040 --> 00:16:42,480
+بنحط ال media في ال petri dish و ال petri dish
+
+217
+00:16:42,480 --> 00:16:46,280
+بندخله داخل ال incubator اللي فيه ال triple gas و
+
+218
+00:16:46,280 --> 00:16:52,040
+37 درجة موية علشان يصير في عندي balance و عملية
+
+219
+00:16:52,040 --> 00:16:57,450
+اتزان في ال pHمهم جدا علشان ما تروح البويضة على
+
+220
+00:16:57,450 --> 00:17:02,010
+أتموسفير أو تروح على ميديا مختلفة اختلاف كل فبيصير
+
+221
+00:17:02,010 --> 00:17:05,830
+فيها shock وممكن يصير failure فتحضير ال media جابل
+
+222
+00:17:05,830 --> 00:17:09,050
+بساعتين من خلال وضعها في الطبق ويدخل الطبق لل
+
+223
+00:17:09,050 --> 00:17:13,630
+incubator بيخل فيه اتزان واستقبال وتكييف للميديا
+
+224
+00:17:13,630 --> 00:17:18,870
+مع الظرف المحيط بها ال oocyte will be arrivedto
+
+225
+00:17:18,870 --> 00:17:22,550
+the metaphase of the second meiotic division stage
+
+226
+00:17:22,550 --> 00:17:29,610
+on the day of collection are stripping
+
+227
+00:17:29,610 --> 00:17:33,230
+and fertilized يعني بمعنى أخر بيسميها الـ
+
+228
+00:17:33,230 --> 00:17:37,330
+denudation بمعنى أخر أن البوايضة اللي كانت في حالة
+
+229
+00:17:37,330 --> 00:17:42,350
+ال maturation و ساحبناها و هي mature لازم في يوم
+
+230
+00:17:42,350 --> 00:17:47,240
+السحب تتعرض لحالتينولا خطواتين الخطوة الأولى الـ
+
+231
+00:17:47,240 --> 00:17:50,980
+Denodation أو الـ Stripping بسموها التعرية وإزالة
+
+232
+00:17:50,980 --> 00:17:54,540
+الكيومال السل و النقطة التانية ال fertilization
+
+233
+00:17:54,540 --> 00:17:59,920
+طبعا together with any in vitro matured oocyte
+
+234
+00:17:59,920 --> 00:18:04,240
+while immature oocyte are collected in IVM media
+
+235
+00:18:04,240 --> 00:18:10,640
+for 24 to 48 hours يعني أي بويضة ناضجة وكانت ناضجة
+
+236
+00:18:10,640 --> 00:18:14,440
+في يوم السحب يجب أن يحدث لها denodation أو
+
+237
+00:18:14,440 --> 00:18:17,760
+strippingو fertilization في نفس اليوم مش أجيله من
+
+238
+00:18:17,760 --> 00:18:21,400
+أي يوم تاني لأ في نفس اليوم السحب بيصير ال
+
+239
+00:18:21,400 --> 00:18:25,920
+injection أما بالنسبة للبوايضة الغير نادجة لازم
+
+240
+00:18:25,920 --> 00:18:30,700
+أوضعها في ال IVM media و يعني ما يطلق عليها in
+
+241
+00:18:30,700 --> 00:18:36,430
+vitro maturation mediaلمدة 24 ساعة على الأقل وعلى
+
+242
+00:18:36,430 --> 00:18:42,150
+الأكثر 48 ساعة لكي يسمح أو نسمح لهذه البويضة
+
+243
+00:18:42,150 --> 00:18:46,730
+بالنضوج الـ Follicle is the basic functional unit
+
+244
+00:18:46,730 --> 00:18:51,050
+of mammalian ovary which each follicle contained a
+
+245
+00:18:51,050 --> 00:18:53,370
+single oocyte surrounded by inner layer of
+
+246
+00:18:53,370 --> 00:18:56,170
+granulosa cell and outer layer of fecal cell
+
+247
+00:18:56,170 --> 00:19:00,650
+الفوليكل هي الوحدة الأساسية التي تحتوي على البويضة
+
+248
+00:19:00,650 --> 00:19:09,360
+الناضجة أو غير ناضجةفبالتالي هذه البويضة و
+
+249
+00:19:09,360 --> 00:19:14,330
+كل بويضة ناضجةتكون محاطة بطبقة خفيفة و رقيقة جدا
+
+250
+00:19:14,330 --> 00:19:17,210
+من الـ granulosa cell بالاضافة .. طبعا هذه طبقة
+
+251
+00:19:17,210 --> 00:19:21,270
+داخلية أو طبقات في بعض الأحيان بتكون داخلية من الـ
+
+252
+00:19:21,270 --> 00:19:25,270
+granulosa cell بالاضافة إلى طبقة أو طبقات متعددة
+
+253
+00:19:25,270 --> 00:19:29,010
+من الخارج تسمى fecal cell وحنشوفها كمان شوية
+
+254
+00:19:29,010 --> 00:19:35,030
+بالصورة يعني في المركز بويضة حواليها طبقات متعددة
+
+255
+00:19:35,030 --> 00:19:39,740
+من الخلايا تسمى الـ granulosa cellومن الخارج طبقات
+
+256
+00:19:39,740 --> 00:19:43,120
+متعددة من الـ fecal cell الـ granulosa cell بتلعب
+
+257
+00:19:43,120 --> 00:19:47,280
+دور مهم جدا بتعمل زي ال nursing يعني زي كأنها
+
+258
+00:19:47,280 --> 00:19:53,000
+بتعمل خادمة أو ممرضة أو يعني حاجة بتسهر على راحة
+
+259
+00:19:53,000 --> 00:19:57,520
+البوادة توفر الأمور اللازمة للبوادة nurse أو
+
+260
+00:19:57,520 --> 00:20:01,540
+nursing the oocyte and differentiated and
+
+261
+00:20:01,540 --> 00:20:06,530
+proliferation in response to gonadotropinالتي مهمة
+
+262
+00:20:06,530 --> 00:20:12,310
+لتطبيق و تضميد و إنعاش البويضة لعنى الـ Granulosa
+
+263
+00:20:12,310 --> 00:20:17,230
+cell بالمجمل تلعب دور مهم جدا في تطبيق و تضميد و
+
+264
+00:20:17,230 --> 00:20:22,550
+إنعاش البويضة كما أنها تلعب دور مهم جدا في تميز و
+
+265
+00:20:22,550 --> 00:20:27,750
+نمو البويضة كما أنها تلعب مهم جدا في استجابة و
+
+266
+00:20:27,750 --> 00:20:31,750
+زيادة استجابة البويضة لل-gonadotropin هرمون الذي
+
+267
+00:20:31,750 --> 00:20:37,630
+يُعطى فبالتاليفهي تلعب دورة حاسمة ودورة مهمة في
+
+268
+00:20:37,630 --> 00:20:42,430
+نجاح نمو البوايضة ونجاح عملية ال ovulation هذا
+
+269
+00:20:42,430 --> 00:20:46,230
+بالنسبة إلى ال granulosa cell بدونها البوايضة لن
+
+270
+00:20:46,230 --> 00:20:51,430
+تنمو بدونها البوايضة لن تنضج بدونها ال ovulation
+
+271
+00:20:51,430 --> 00:20:55,970
+لن يحدث لأن حكينا إنها بتلعب دور كبير وسارفنا إيش
+
+272
+00:20:55,970 --> 00:20:58,730
+الدور اللي بتلعبه من أهمها ال response for
+
+273
+00:20:58,730 --> 00:21:02,250
+gonadotropin على سبيل المثالThere are bi
+
+274
+00:21:02,250 --> 00:21:05,830
+-directional communication between the oocyte and
+
+275
+00:21:05,830 --> 00:21:09,290
+the surrounding somatic cell من خلال الـ Gap
+
+276
+00:21:09,290 --> 00:21:13,430
+Injection and Paracrine Signal طبعا الـ Somatic
+
+277
+00:21:13,430 --> 00:21:17,730
+Cell أو الـ Oocyte خليني أسميها بالمجمل ما بتكون
+
+278
+00:21:17,730 --> 00:21:22,750
+في معزل عن الخلايا الأخرى أو البيئة المحيطة فيها
+
+279
+00:21:22,750 --> 00:21:27,610
+لأ في عندي connection تؤثر وتتأثر تتأثر بالبيئة
+
+280
+00:21:27,610 --> 00:21:31,610
+المحيطة وتؤثر على البيئة المحيطةمن خلال junction
+
+281
+00:21:31,610 --> 00:21:34,270
+gap موجودة ما بينها وما بين الـ somatic cell
+
+282
+00:21:34,270 --> 00:21:38,710
+المحيطة بها ومن خلال ما يُعرف اسم الـ Paracrine
+
+283
+00:21:38,710 --> 00:21:42,650
+Signal ويعرفين الناس اللي أخدت Indocrine في حسمة
+
+284
+00:21:42,650 --> 00:21:48,690
+Autocrine في Paracrine وفي أنواع مختلفة من ال
+
+285
+00:21:48,690 --> 00:21:52,230
+signal من Indocrine و Paracrine و Autocrine هذه
+
+286
+00:21:52,230 --> 00:21:57,370
+أنواع مختلفة من ال signal بتفرز بالفعل الخلايا
+
+287
+00:21:57,370 --> 00:22:02,090
+الموجودة طبعاهذه العملية بتسهل بشكل كبير جدا نمو
+
+288
+00:22:02,090 --> 00:22:05,890
+البوايضة و تطور البوايضة الموجودة داخل الـ
+
+289
+00:22:05,890 --> 00:22:08,850
+follicle مما يؤدي إلى نجاح عملية الـ
+
+290
+00:22:08,850 --> 00:22:14,690
+folliculogenesis عملية تطور البوايضة نجد المرحلة
+
+291
+00:22:14,690 --> 00:22:18,230
+الأولى التي تحدث و العملية الأولى التي تحدث بعد
+
+292
+00:22:18,230 --> 00:22:21,530
+عملية الـ collection و هي ما يُعرف اسم oocyte
+
+293
+00:22:21,530 --> 00:22:25,510
+denodation أو denoding في الغالب بيسموها stripping
+
+294
+00:22:25,510 --> 00:22:30,030
+أو denodation يعني التعرية أو الإزالةطبعاً لما
+
+295
+00:22:30,030 --> 00:22:34,550
+أقول oocyte denoding تعني إزالة الـ somatic cell
+
+296
+00:22:34,550 --> 00:22:38,890
+المحيطة بالـ oocyte لأن أنا ما بدي أثناء عملية ال
+
+297
+00:22:38,890 --> 00:22:43,650
+injection أدخل somatic cell داخل الـ oocyte خلال
+
+298
+00:22:43,650 --> 00:22:46,510
+عملية ال injection أو جزء من المادة الوراثية
+
+299
+00:22:46,510 --> 00:22:49,770
+الخاصة بالـ somatic cell تدخل مع الإبرة خلال عملية
+
+300
+00:22:49,770 --> 00:22:52,830
+ال injection فبدي أزيل أغلب الـ somatic cell
+
+301
+00:22:52,830 --> 00:22:56,670
+المحيطة بالـ oocyte علشان أعمل injection بشكل صحيح
+
+302
+00:22:57,000 --> 00:23:00,980
+و مضمون 100% The removal of cumulus cell become
+
+303
+00:23:00,980 --> 00:23:04,860
+critical step, very necessary step, very important
+
+304
+00:23:04,860 --> 00:23:09,940
+step before fertilization since it allow an
+
+305
+00:23:09,940 --> 00:23:14,940
+evaluation of oocyte nuclear maturity and easily
+
+306
+00:23:14,940 --> 00:23:19,150
+handling of the oocyteDuring manipulation عملية
+
+307
+00:23:19,150 --> 00:23:22,790
+الإزالة عملية الـ stripping تسمح لأنا ك تكنولوجيست
+
+308
+00:23:22,790 --> 00:23:27,370
+أقيم ال Oocyte بشكل صحيح هل هي M1 ولا M2 ولا GV
+
+309
+00:23:27,370 --> 00:23:32,170
+أيضا بسهل عملية ال injection أن أعمل injection في
+
+310
+00:23:32,170 --> 00:23:35,510
+منطقة بعيدة عن ال polar body أعمل injection في
+
+311
+00:23:35,510 --> 00:23:39,130
+منطقةتحتوي على كمية قليلة جدا من الـ somatic cell
+
+312
+00:23:39,130 --> 00:23:44,270
+The cumulus and corona cell are removed before any
+
+313
+00:23:44,270 --> 00:23:49,670
+step of micromanipulation procedure by using two
+
+314
+00:23:49,670 --> 00:23:54,190
+method enzymatic method و mechanical treatment أنا
+
+315
+00:23:54,190 --> 00:23:57,770
+ممكن أعمل denodation أو stripping قبل ما أعمل أي
+
+316
+00:23:57,770 --> 00:24:01,400
+خطوة من خطوات ال injectionإما بستخدم إنزيم، هنعرف
+
+317
+00:24:01,400 --> 00:24:06,100
+إيش هو الإنزيم وكيف بستخدمه أو بستخدم طريقة يدوية،
+
+318
+00:24:06,100 --> 00:24:10,320
+ميكانيكية من أشهر الإنزيمات اللي تستخدم هو إنزيم
+
+319
+00:24:10,320 --> 00:24:15,600
+يؤثر على مادة تسمى الـ Hyaluronic Acid الـ
+
+320
+00:24:15,600 --> 00:24:18,260
+Hyaluronic Acid مادة بتعمل عملية تلاحق ما بين
+
+321
+00:24:18,260 --> 00:24:23,880
+الخلية و تباصق ما بين الخلية فبصير عملية زعزعة
+
+322
+00:24:23,880 --> 00:24:26,660
+الخلايا أو إزالة الخلايا صعب هذا الـ Hyaluronic
+
+323
+00:24:26,660 --> 00:24:32,630
+Acid فبدي مادة تشتغل عليه و تزيلههيالورينك أسد هو
+
+324
+00:24:32,630 --> 00:24:38,050
+مجموعة كبيرة من مجموعة كيومولاس المتحركة التي تجمع
+
+325
+00:24:38,050 --> 00:24:41,850
+الهيالورينك أسد فبالتالي بستخدم إنزيم اسمه
+
+326
+00:24:41,850 --> 00:24:47,850
+هيورينيداز اللي بلعب دوري كتير جدا في إزالة وتقطيع
+
+327
+00:24:47,850 --> 00:24:52,510
+الهيالورينك أسد مما يؤدي إلى إزالة الخلايا ده
+
+328
+00:24:52,510 --> 00:24:56,870
+البروسيجير عادةً يتم تفعيله تحت ميكروسكوب ستيريو
+
+329
+00:24:58,790 --> 00:25:00,970
+الأنواع الأجهزة الموجودة أشهر على الـ
+
+330
+00:25:00,970 --> 00:25:04,990
+Stereomicroscope Indifferent well or micro drop
+
+331
+00:25:04,990 --> 00:25:09,170
+containing content buffer media usually covered by
+
+332
+00:25:09,170 --> 00:25:13,350
+oil on the warm thermoplane Stereomicroscope هو
+
+333
+00:25:13,350 --> 00:25:18,570
+عبارة عن ميكروسكوب الـ stage الخاص بيه بيكون فيه
+
+334
+00:25:18,570 --> 00:25:24,930
+heating stage يعني موصول ببطارية بتعطي حرارةأو
+
+335
+00:25:24,930 --> 00:25:28,710
+heater بيعطي حرارة 37 درجة مئوية عشان تكون قريبة
+
+336
+00:25:28,710 --> 00:25:33,950
+من درجة حرارة الجسم وأنا بستخدم طبق فيه drop أو
+
+337
+00:25:33,950 --> 00:25:37,950
+فيه well كل well فيها media موجود بداخلها البويضات
+
+338
+00:25:37,950 --> 00:25:42,250
+الناضجة ومغطى بال oil عشان أمنع ال contamination
+
+339
+00:25:42,250 --> 00:25:46,330
+دخول أي شيء من الخارج داخل ال media فبالتالي بيؤثر
+
+340
+00:25:46,330 --> 00:25:51,650
+سلبا على البويضاتكيف انا ممكن اسرع و ادى عملية ال
+
+341
+00:25:51,650 --> 00:25:55,470
+removing لل cumulus و ال corona cell بستخدم انزيم
+
+342
+00:25:55,470 --> 00:26:00,790
+اسمه اللي هي lorandase enzyme او ممكن اعمل
+
+343
+00:26:00,790 --> 00:26:04,570
+stripping شو يعني stripping ببساطة جدا بجيب
+
+344
+00:26:04,570 --> 00:26:07,450
+plastic dropper استرايه plastic dropper إلى gauge
+
+345
+00:26:07,450 --> 00:26:12,610
+معين او ديامتر معين هيكون اكبر بقليل او اصغر بقليل
+
+346
+00:26:12,610 --> 00:26:17,220
+من ال oocyteو بعمل suction و releasing suction و
+
+347
+00:26:17,220 --> 00:26:21,020
+releasing حوالي 7-8 مرات خلال عملية ال suction و
+
+348
+00:26:21,020 --> 00:26:23,880
+ال releasing أو ال aspiration و ال releasing لل
+
+349
+00:26:23,880 --> 00:26:27,900
+oocyte بيصير خلخلة في ال cumulus cell و تفتت أنا
+
+350
+00:26:27,900 --> 00:26:30,920
+كده بكون خلصتها بعد ما أعمل عشر مرات في ال drop
+
+351
+00:26:30,920 --> 00:26:34,040
+هذه باخد ال void و بالقلها ل drop جديدة و مظيفة
+
+352
+00:26:34,040 --> 00:26:39,810
+مافيها أي شوائب أو مافي حدث فيهاSuction و
+
+353
+00:26:39,810 --> 00:26:42,430
+Releasing للجوايدات يعني مافيها خلايا طبعا هذه
+
+354
+00:26:42,430 --> 00:26:44,910
+العملية عملية ال aspiration و ال releasing لل
+
+355
+00:26:44,910 --> 00:26:48,750
+oocyte ممكن تكرر بالعدد 20 مرة أو لمدة اعمالها
+
+356
+00:26:48,750 --> 00:26:51,950
+كررها لمدة 30 ثانية يعني انت بدك بالوقت او بدك
+
+357
+00:26:51,950 --> 00:26:58,770
+بالعدد سين once initial cell this خلينا نسميها
+
+358
+00:26:58,770 --> 00:27:04,130
+removing is observed oocyte are removed to the
+
+359
+00:27:04,130 --> 00:27:07,310
+second well droplet containing buffer media taking
+
+360
+00:27:07,310 --> 00:27:11,640
+careto carry over minimum amount of enzyme طبعا
+
+361
+00:27:11,640 --> 00:27:15,560
+هذه ال media ممكن تكون media وفيها انزيم الانزيم
+
+362
+00:27:15,560 --> 00:27:19,120
+المسئول عن خلخلة ال hyaluronic acid بالاضافة إلى
+
+363
+00:27:19,120 --> 00:27:21,740
+ال aspiration و ال releasing فبصير عندي mechanical
+
+364
+00:27:21,740 --> 00:27:26,000
+aspiration releasing و enzymatic وجود الانزيم بعد
+
+365
+00:27:26,000 --> 00:27:30,100
+ما أعمل aspiration و releasing لمدة 30 ثانية بنقل
+
+366
+00:27:30,100 --> 00:27:34,250
+البوايدة هذه إلى قطرة جديدةلم يحدث فيها عملية
+
+367
+00:27:34,250 --> 00:27:37,090
+removing للـ Oocyte طبعاً بكرر هذه العملية مرة و
+
+368
+00:27:37,090 --> 00:27:42,790
+مرتين و تلاتة حتى أتأكد أن كمية الكيوملة السل
+
+369
+00:27:42,790 --> 00:27:47,050
+المحيطة بالـ Oocyte قليلة جداً جداً جداً جداً
+
+370
+00:27:47,050 --> 00:27:50,350
+طبعاً في القطرة الأولى بستخدم الـ dropper بدياميتر
+
+371
+00:27:50,350 --> 00:27:53,370
+معين في القطرة التالية بستخدم الـ dropper بدياميتر
+
+372
+00:27:53,370 --> 00:27:58,070
+أقل لأن كل منقل البويضة من قطرة لقطرة جديدة الـ
+
+373
+00:27:58,070 --> 00:28:01,710
+Oocyte الدياميتر بتقل و الكيوملة السل الحواليها
+
+374
+00:28:01,710 --> 00:28:05,730
+بتقلفبالتالي بدّي Dropper جديدة بـ Diameter أقل
+
+375
+00:28:05,730 --> 00:28:10,250
+عشان أقدر أعمل قوة احتكار أثناء دخول وخرول
+
+376
+00:28:10,250 --> 00:28:17,070
+البوايضة من الفوه .. من الفوهات الأنبوبة طيب،
+
+377
+00:28:17,070 --> 00:28:21,710
+لازم أعمل Washing للـ Oocyte بشكل كامل علشان أوقف
+
+378
+00:28:21,710 --> 00:28:25,810
+عملية عمل الـEnzyme عشان مايضلش فيه Enzyme مرتبط
+
+379
+00:28:25,810 --> 00:28:29,350
+بخلايا الكيوميلاصيل المتبقية وبالتالي أنا بعمل
+
+380
+00:28:29,350 --> 00:28:33,540
+Stopping لعمل الEnzyme فلازم أعملها Washingبعد
+
+381
+00:28:33,540 --> 00:28:36,180
+after partially removal of the cumulus cell by
+
+382
+00:28:36,180 --> 00:28:40,400
+short exposure أو exposure to buffered media
+
+383
+00:28:40,400 --> 00:28:45,960
+contained an enzyme the oocyte are removed and put
+
+384
+00:28:45,960 --> 00:28:49,400
+in the culture media and placed back to the
+
+385
+00:28:49,400 --> 00:28:52,960
+incubator for 30 minutes أنا عملت Deunidation كامل
+
+386
+00:28:52,960 --> 00:28:57,220
+ماخلت ولا cumulus cell حوالين الخلية أو عدد قليل
+
+387
+00:28:57,220 --> 00:29:06,110
+جدا باخد ال oocyte بضيفه في mediaClear Media بدخل
+
+388
+00:29:06,110 --> 00:29:09,530
+الطبق للإنكبيوتر عشان الخلية تستقر لأجل أن أنا
+
+389
+00:29:09,530 --> 00:29:16,030
+كانت مجهدة بفعل وجود الإنزيم وعملية ال aspiration
+
+390
+00:29:16,030 --> 00:29:20,630
+و ال releasing لمدة 30 دقيقة على الأقل قبل ال
+
+391
+00:29:20,630 --> 00:29:25,150
+injection يعني قبل .. ما بين ال stripping و ما بين
+
+392
+00:29:25,150 --> 00:29:29,110
+ال injection في فترة زمانية تسمى rested stage خاصة
+
+393
+00:29:29,110 --> 00:29:34,970
+براحةلازم تحتاجها الـ oocyte عشان لا تجهد في نوع
+
+394
+00:29:34,970 --> 00:29:37,630
+من أنواع الاستقرار المادة الوراثية بداخلها تقدر
+
+395
+00:29:37,630 --> 00:29:43,270
+بتلاتين دقيقة على حد أدنى ف future step أو this
+
+396
+00:29:43,270 --> 00:29:49,890
+future step led to طبعا عملية ال mixing للبوايضة
+
+397
+00:29:49,890 --> 00:29:53,950
+مع ال media اللي بتحتوي على الهيرون ديز as enzyme
+
+398
+00:29:53,950 --> 00:29:58,650
+تعمل عملية tweaking لقوة الترابط ما بين القلاعين
+
+399
+00:29:58,650 --> 00:30:02,680
+فبسهل عملية ال removingبعد الـdenodation الـ
+
+400
+00:30:02,680 --> 00:30:05,480
+Oocyte should be examined under inverted
+
+401
+00:30:05,480 --> 00:30:09,940
+microscope to assess integrity and the stage of
+
+402
+00:30:09,940 --> 00:30:13,480
+maturation عملت الـ denodation جاب المداخلة في الـ
+
+403
+00:30:13,480 --> 00:30:17,980
+incubator لمدة 30 دقيقة طلّق البوادة نقولها عن
+
+404
+00:30:17,980 --> 00:30:20,360
+inverted microscope فشوفها تحت ال inverted
+
+405
+00:30:20,360 --> 00:30:24,440
+microscope شو ال integrity تبعتها؟ جداش ال
+
+406
+00:30:24,440 --> 00:30:28,150
+maturation stage تبعتها؟ هل هي M1 ولا M2؟ولّا أي
+
+407
+00:30:28,150 --> 00:30:31,750
+نوع من أنواع يعني تصلح أم لا تصلح لعملية ال
+
+408
+00:30:31,750 --> 00:30:36,030
+fertilization the incomplete denodation of oocyte
+
+409
+00:30:36,030 --> 00:30:39,710
+before eggsy يعني في بعض الناس بيقولك لأ أنا بتعمل
+
+410
+00:30:39,710 --> 00:30:43,810
+complete denodation ما بتخلي أي cumula cell بهدوء
+
+411
+00:30:43,810 --> 00:30:47,030
+لازم يكون فيه جزء من ال cumula cell لأن هذا بيفيد
+
+412
+00:30:47,030 --> 00:30:50,430
+ال oocyte كيف بيفيد ال oocyte؟ لأنه في دراسات
+
+413
+00:30:50,430 --> 00:30:54,710
+بتقولك عملية ال denodation الغير كاملة يعني التي
+
+414
+00:30:54,710 --> 00:30:57,950
+تترك عدد قليل من ال cumula cellطبقة محيطة بالـ
+
+415
+00:30:57,950 --> 00:31:02,030
+Oocyte تساعد في تحسين جودة الـ embryo بعد ال
+
+416
+00:31:02,030 --> 00:31:05,730
+fertilization وتساعد في تحسين الـ developmental
+
+417
+00:31:05,730 --> 00:31:10,230
+embryo أيضًا تلعب دور كبير جدًا في الـ assist
+
+418
+00:31:10,230 --> 00:31:13,770
+embryonic metabolism و ال stimulation gene
+
+419
+00:31:13,770 --> 00:31:17,810
+expression تعمل reduction لل oxidative stress يعني
+
+420
+00:31:17,810 --> 00:31:22,490
+مش شضارة ولا دقة في الأداء إنك تتعرّض الخلية بشكل
+
+421
+00:31:22,490 --> 00:31:26,740
+الكامل و ما تخلّي أي كيوم للسلحة حولها، لأخفف قدر
+
+422
+00:31:26,740 --> 00:31:31,100
+الإمكان و افقي و لو two layers حوالها عدد قليل من
+
+423
+00:31:31,100 --> 00:31:34,060
+الخلايا إنك انت ماتضرك الخلايا أثناء عملية ال
+
+424
+00:31:34,060 --> 00:31:38,840
+injection و ماتضر الجنين لإن وجودها مفيد في أربع
+
+425
+00:31:38,840 --> 00:31:42,820
+أو خمس نقاط بتساعد ال embryo quality أو بتحسن ال
+
+426
+00:31:42,820 --> 00:31:46,260
+embryo quality و ال embryo development و بتعمل أسس
+
+427
+00:31:46,260 --> 00:31:49,560
+embryonic metabolism بتعمل stimulation لـ Angelic
+
+428
+00:31:49,560 --> 00:31:52,440
+suppression وتعمل reduction لل oxidative stress
+
+429
+00:31:52,440 --> 00:31:59,330
+خمس فوائدمهمة لبقاء كمية من كيومة الـ cell حوالين
+
+430
+00:31:59,330 --> 00:32:06,350
+الـ Oocyte طبعا هذه ببساطة جدا شكل الـ Oocyte لما
+
+431
+00:32:06,350 --> 00:32:11,050
+تطلع هذه شكل الـ Oocyte لما تطلع من ال fluid و أنا
+
+432
+00:32:11,050 --> 00:32:13,850
+أحصلها من ال fluid لو أنقلها لقطرة جديدة هذه بتكون
+
+433
+00:32:13,850 --> 00:32:19,470
+كلها عبارة عن الـ Oocyte ولكن لو أنا فرغت هذه الـ
+
+434
+00:32:19,470 --> 00:32:24,350
+Oocyteوهذه كلها cumulus cell و corona cell حوالها
+
+435
+00:32:24,350 --> 00:32:28,310
+بعد ال denodation لازم تكون بهذا الشكل طبعا هذا
+
+436
+00:32:28,310 --> 00:32:31,470
+اللي باللون الأحمر هذا خلينا نسميه هذا ال zoona
+
+437
+00:32:31,470 --> 00:32:35,490
+وهذا ال polar body وهذا ال polar body وهذه كلها
+
+438
+00:32:35,490 --> 00:32:42,550
+طبقة من ال cytoplasm هاي ال oocyte اللي باللون
+
+439
+00:32:42,550 --> 00:32:46,290
+الأخضر الفاتح بيسموها cumulus cell اللي باللون
+
+440
+00:32:46,290 --> 00:32:50,520
+الأخضر الداكن موريلا وهذا ال thica cellطبعاً لما
+
+441
+00:32:50,520 --> 00:32:55,100
+أجى أعمل aspiration و releasing سكشن و releasing
+
+442
+00:32:55,100 --> 00:33:00,740
+هتروح كل هدوء يدل اللي باللون الأخضر الفاتح و هي
+
+443
+00:33:00,740 --> 00:33:04,840
+الكيومولا السل لازم انا اتجنب كمية كبيرة جدا ال
+
+444
+00:33:04,840 --> 00:33:08,880
+granulosa cell هي عبارة عن خليط من الموريلا cell و
+
+445
+00:33:08,880 --> 00:33:15,650
+الكيومولا cell دعونانرى هذا الفيديو المتعلق بعملية
+
+446
+00:33:15,650 --> 00:33:20,270
+ال denotation علشان تكون الأمر أوضح ان شاء الله
+
+447
+00:33:20,270 --> 00:33:27,090
+طبعا
+
+448
+00:33:27,090 --> 00:33:34,970
+هيتكلم عن ال denotation تحت ال microscope طبعا
+
+449
+00:33:34,970 --> 00:33:38,290
+هذه ال pasteur tube او pasteur pipet او dropper
+
+450
+00:33:38,290 --> 00:33:43,280
+طبعا هنا هذه البوايضات الليموجودة فيها بيعمل
+
+451
+00:33:43,280 --> 00:33:45,780
+suction بداخل البيضات للداخل وبعدين بيعملها
+
+452
+00:33:45,780 --> 00:33:49,040
+releasing أكتر من مرة وشوف كيف بيصير تفتت لل
+
+453
+00:33:49,040 --> 00:33:49,500
+cumulus
+
+454
+00:34:24,960 --> 00:34:27,440
+و اخدوا بالكوا في الخطوة التانية اغير ال pipet يا
+
+455
+00:34:27,440 --> 00:34:31,580
+بابت اقل ال diameter تبعها اقل لان الخلية او
+
+456
+00:34:31,580 --> 00:34:35,120
+البويضة فقدت الجرانيلوزا سيل فقدت الكيوركيوميلاس
+
+457
+00:34:35,120 --> 00:34:39,120
+سيل فصغر حجمها فابدي ب steer pipet ال diameter اقل
+
+458
+00:35:22,520 --> 00:35:25,720
+شايفين في كل مرة بيعمل aspiration و releasing
+
+459
+00:35:25,720 --> 00:35:29,140
+بيعمل في منطقة جديدة علشان ما يصير الشواقب حوالها
+
+460
+00:35:29,140 --> 00:35:33,320
+و في كل مرة بعد فترة زمنية بعد ما يعمل يعني خمسين
+
+461
+00:35:33,320 --> 00:35:37,700
+عشر مرات عشرين مرة خمسين ثانية بنقل هذه ال oxide
+
+462
+00:35:37,700 --> 00:35:40,300
+كلها بداخلها داخل ال dropout او داخل ال pasture
+
+463
+00:35:40,300 --> 00:35:41,940
+pipe و بنقلها ل drop جديد
+
+464
+00:36:07,360 --> 00:36:10,260
+شوف كيف شكل البويضات هي عندي واحدة ..تنتين ..تلاتة
+
+465
+00:36:10,260 --> 00:36:12,840
+..اربعة ..خمسة ..ستة ..سبعة ..تمانية ..عشرة
+
+466
+00:36:12,840 --> 00:36:16,220
+..احداشر بويضة من سيدة واحدة اللي كانت مفروضة تطلع
+
+467
+00:36:16,220 --> 00:36:19,500
+فقط تلت بويضات كحد أقصى هذا طبعا بعد ال
+
+468
+00:36:19,500 --> 00:36:25,200
+stimulation هذه
+
+469
+00:36:25,200 --> 00:36:28,320
+طريقة ال stripping أو ال denodation الخاصة
+
+470
+00:36:28,320 --> 00:36:30,660
+بالاواصيت خليني أشوف فيديو تاني يتكلم عن هذا
+
+471
+00:36:30,660 --> 00:36:31,120
+الموضوع
+
+472
+00:36:37,110 --> 00:36:40,190
+طبعا هذا شكل البوايضات أول ما نحزلهم من ال fluid
+
+473
+00:36:40,190 --> 00:36:42,990
+أو من ال flucular fluid بكون شكلهم بهذا الشكل زي
+
+474
+00:36:42,990 --> 00:36:45,790
+ما شوفناها تحت الصورة هذه البوايضة و هذه كل
+
+475
+00:36:45,790 --> 00:36:49,830
+الثيكاسيل و الكيملاسسيل و ال موريلاسيل و ال
+
+476
+00:36:49,830 --> 00:36:53,410
+somatic cell كلها محيطة فيها بده يعملها pipetting
+
+477
+00:36:53,410 --> 00:36:59,370
+هالوقت بيجي بالدربر بيعملها suction و releasing
+
+478
+00:36:59,370 --> 00:37:06,230
+لمدة تلاتين ثانية على الأقل مش وجدش ال diameter
+
+479
+00:37:08,580 --> 00:37:11,900
+الخاصة بال بستير بايبت أو الخاصة بالدروبة اللي
+
+480
+00:37:11,900 --> 00:37:15,740
+لازم تكون استراتيك خمسة، ستة، سبعة، تمان مرات أو
+
+481
+00:37:15,740 --> 00:37:22,100
+تلاتين ثانية كحد أدنى و بعدين بيعملهم transfer إلى
+
+482
+00:37:22,100 --> 00:37:25,880
+a new drop علشان يتخلص من كمية الشباب هاي فال new
+
+483
+00:37:25,880 --> 00:37:29,980
+drop عملها releasing و بعدين بيعملهم suction و
+
+484
+00:37:29,980 --> 00:37:33,640
+releasing بس بده يغير ال bybitتغير بايبت لأنه بده
+
+485
+00:37:33,640 --> 00:37:38,020
+بايبت الديامتر تبعته أقل علشان يقدر يصير قوة
+
+486
+00:37:38,020 --> 00:37:42,300
+احتكاك ما بين الجدار الداخل للأنبوبة و البويضة
+
+487
+00:37:42,300 --> 00:37:45,800
+واحدة واحدة و في بعضهم بيعملها كاملة ولكن افضل
+
+488
+00:37:45,800 --> 00:37:49,980
+واحدة واحدة علشان مايصيرش تزاحم و مما يدى لتهتك
+
+489
+00:37:49,980 --> 00:37:54,800
+الخلايا في بعض الأحيان ممكن يعيدها تلاتين ثانية زي
+
+490
+00:37:54,800 --> 00:37:59,200
+ما قلنا و ينتقل إلى drop جديدة فيما بعد هينقل إلى
+
+491
+00:37:59,200 --> 00:38:04,880
+drop جديدة هيغير ال بايبتالمفروض يغير الـ Pivot
+
+492
+00:38:04,880 --> 00:38:09,980
+علشان يعطيني نتائج أفضل يعطيني Diameter Pivot with
+
+493
+00:38:09,980 --> 00:38:15,580
+low diameter اكبر
+
+494
+00:38:15,580 --> 00:38:21,900
+البوايضات هتشوفهم بهذا الشكل هذه فكرة الـ
+
+495
+00:38:21,900 --> 00:38:25,800
+Denotation بشكل أساسي كيف بتصير عملية الـ
+
+496
+00:38:25,800 --> 00:38:29,760
+Denotation اتعرفنا عنها بعد ما حكينا عن الـ
+
+497
+00:38:29,760 --> 00:38:32,900
+Denotationالـ timing للـ oocyte denodation الـ
+
+498
+00:38:32,900 --> 00:38:37,160
+oocyte denodation is usually performed between 37
+
+499
+00:38:37,160 --> 00:38:42,220
+and 40 hours after HCG يعني عملية الـ denodation
+
+500
+00:38:42,220 --> 00:38:46,360
+بتصير بعد عملية ال injection للشريجون أو لل human
+
+501
+00:38:46,360 --> 00:38:50,540
+chronic gonadotropin اللي بيعمل ovulation بـ 37
+
+502
+00:38:50,540 --> 00:38:56,050
+إلى 40 ساعة ولكن يجب أن تحدثقبل الـ insemination
+
+503
+00:38:56,050 --> 00:39:00,250
+بساعة أو نص ساعة على الأقل الإنزيمات التي تستخدم
+
+504
+00:39:00,250 --> 00:39:04,670
+وتركيزها بشكل عام وtraditionally الـdenodation أو
+
+505
+00:39:04,670 --> 00:39:09,050
+الـ denoding process أو procedure involve a
+
+506
+00:39:09,050 --> 00:39:14,670
+poivrein derivative هيلورينيدازي يعني هيلورينيدازي
+
+507
+00:39:14,670 --> 00:39:19,490
+مع مشتق من الـpoivrein بشكل أساسي in order to
+
+508
+00:39:19,490 --> 00:39:23,130
+minimum any potential toxic effect on oocyte for
+
+509
+00:39:23,130 --> 00:39:26,420
+this type of enzymewe should be reduce the
+
+510
+00:39:26,420 --> 00:39:28,440
+enzymatic concentration or the enzyme
+
+511
+00:39:28,440 --> 00:39:33,340
+concentration or reduce that duration for oocyte
+
+512
+00:39:33,340 --> 00:39:37,640
+exposure to this type of enzyme يعني أنا ممكن أجلل
+
+513
+00:39:37,640 --> 00:39:39,840
+ال toxicity الخاصة بهذا الانزيم بطريقة تانية
+
+514
+00:39:39,840 --> 00:39:43,500
+الطريقة الأولى أنه أجلل ال time اللي بتتعرض فيه
+
+515
+00:39:43,500 --> 00:39:47,540
+الخلية لهذا الانزيم أو أجلل ما يُعرف باسم ال
+
+516
+00:39:47,540 --> 00:39:50,440
+concentration الخاصة فيه وفي بعضهم بيجلد ال time
+
+517
+00:39:50,440 --> 00:39:54,760
+أفضل لإن ال concentration بيكون fixedأقل الـ
+
+518
+00:39:54,760 --> 00:39:57,540
+concentration ممكن أن أستخدم خلال الـ denotation
+
+519
+00:39:57,540 --> 00:40:02,040
+80 international units per milliliter يعني لو الـ
+
+520
+00:40:02,040 --> 00:40:05,620
+one drop فيها 80 unit ممكن أن أضع هذه الـ one drop
+
+521
+00:40:05,620 --> 00:40:10,520
+من الإنزيم على 1 مليليتر من ال media وكل ما كان
+
+522
+00:40:10,520 --> 00:40:15,620
+أقل تركيزه وكل ما كان تأثير السلبي أقل أو ال
+
+523
+00:40:15,620 --> 00:40:20,830
+toxicity أقل فممكن أناأخفض درجة حرارته .. عفوا ..
+
+524
+00:40:20,830 --> 00:40:24,870
+أخفض تركيزه وأخفض effect تبعته إن أستخدم تركيز
+
+525
+00:40:24,870 --> 00:40:28,470
+عشرة international unit per milliliter بعض
+
+526
+00:40:28,470 --> 00:40:32,170
+الدراسات قالت إن هذا التركيز has also been shown
+
+527
+00:40:32,170 --> 00:40:37,970
+to be able to make denotation for mature oocyte
+
+528
+00:40:37,970 --> 00:40:43,150
+بشكل عالي جدا يعني العشرة international unit قادرة
+
+529
+00:40:43,150 --> 00:40:46,190
+أن تعمل denotation وبكفاءة عالية جدا فأنا ليش
+
+530
+00:40:46,190 --> 00:40:49,690
+أستخدم التمانين؟فلو بدى أستخدم الـ 80 بدي أقلل ال
+
+531
+00:40:49,690 --> 00:40:53,490
+duration لازم
+
+532
+00:40:53,490 --> 00:40:57,230
+أقلل ال duration خلصنا كده من عملية ال denodation
+
+533
+00:40:57,230 --> 00:40:59,790
+و ال stripping جاهز لعملية ال injection اللى
+
+534
+00:40:59,790 --> 00:41:04,570
+هناخدها في الشكتر الجديد ولكن قبل ما نخلص الموضوع
+
+535
+00:41:04,570 --> 00:41:09,570
+ده فيه موضوع صغير بتنوح له وهو هرمون ال EAMH ال
+
+536
+00:41:09,570 --> 00:41:14,170
+EAMH ببساطة جدا يا طلابنا الأعزاء هو عبارة عن
+
+537
+00:41:14,170 --> 00:41:18,730
+هرمون يطلق عليه protein هرمونيُفرز بشكل أساسي من
+
+538
+00:41:18,730 --> 00:41:22,350
+الـ granulosa cell in the ovarian follicle in the
+
+539
+00:41:22,350 --> 00:41:27,130
+ovarian follicle لما تكون أو يكون عند سيدة تفرز ال
+
+540
+00:41:27,130 --> 00:41:29,830
+ovarian follicle هرمون أو ال granulosa cell
+
+541
+00:41:29,830 --> 00:41:32,250
+الموجودة في ال ovarian follicle تفرز هرمون
+
+542
+00:41:32,250 --> 00:41:35,590
+antimolarin هرمون خدوا بالك هذا الهرمون مهم جدا
+
+543
+00:41:35,590 --> 00:41:39,790
+وبناء عليه بعض الأضطراب بيستخدموه عشان يحددوا هدى
+
+544
+00:41:39,790 --> 00:41:43,630
+الزوجة أو هدى السيدة تروح agonist أو antagonist
+
+545
+00:41:43,630 --> 00:41:48,700
+short protocol ولا long protocolوبعضهم بيستخدم ال
+
+546
+00:41:48,700 --> 00:41:51,740
+A match عشان يحدد ال shorter protocol أو ال longer
+
+547
+00:41:51,740 --> 00:41:55,840
+protocol شو هيختار طبعا ال A match level بلعب دور
+
+548
+00:41:55,840 --> 00:42:01,120
+كبير جدا حيث أنه يزيد بعد ال 25 سنة عند السيدات
+
+549
+00:42:01,120 --> 00:42:05,800
+ويبدأ في التناقص بعد ال 30 أو عند 30 سنة ال A
+
+550
+00:42:05,800 --> 00:42:10,060
+match بلعب دور كبير جدا في ال development of sex
+
+551
+00:42:10,060 --> 00:42:15,400
+organ في ال unborn baby كيف بلعب هذا الدور؟بقولك
+
+552
+00:42:15,400 --> 00:42:20,420
+ببساطة جدا في أول أسابيع من الحمل ال baby will be
+
+553
+00:42:20,420 --> 00:42:24,240
+start reproductive organ development إذا كان ال
+
+554
+00:42:24,240 --> 00:42:28,960
+baby male فهيفرس كمية كبيرة جدا من ال AMH علشان
+
+555
+00:42:28,960 --> 00:42:33,700
+يمنع تكوين بالإضافة طبعا إلى ال male hormone علشان
+
+556
+00:42:33,700 --> 00:42:40,180
+يمنع تكوين ال female organ development ويسمح
+
+557
+00:42:40,180 --> 00:42:47,160
+بتكوين ال maledeveloped male organ يعني ال AMH
+
+558
+00:42:47,160 --> 00:42:52,860
+يفرز في المرحلة الجنينية إذا كان الجنين ذكر يفرز
+
+559
+00:42:52,860 --> 00:42:57,680
+كمية كبيرة جدا من ال AMH plus ال sex hormone الخاص
+
+560
+00:42:57,680 --> 00:43:02,460
+بالذكور مما يمنع تكوين ال organ الخاص بال female
+
+561
+00:43:02,460 --> 00:43:08,060
+organويسمح ويساعد على إنتاج وتكوين ال organ الخاص
+
+562
+00:43:08,060 --> 00:43:13,340
+بالمال لو كان العكس عند ال unborn baby في المرحلة
+
+563
+00:43:13,340 --> 00:43:17,500
+الجنينية female كمية اللي قد أبقاش هتقل، هتكون أقل
+
+564
+00:43:17,500 --> 00:43:23,940
+ما يمكن و تكاد تكون غير مذكورة مما يسمح بظهور ال
+
+565
+00:43:23,940 --> 00:43:27,680
+organ related with female و عدم ظهور ال organ
+
+566
+00:43:27,680 --> 00:43:33,510
+related with male مما يؤدي إلى ظهور الجنين كجنين
+
+567
+00:43:33,510 --> 00:43:39,230
+أنثى عشان كده بعض الأطباء وبعض المراكز ممكن تستخدم
+
+568
+00:43:39,230 --> 00:43:42,570
+ال AMH تحديد مستوى ال AMH في المرحلة الجنينية
+
+569
+00:43:42,570 --> 00:43:47,470
+لتحديد جنس المولود هل هو male أو female إذا كان
+
+570
+00:43:47,470 --> 00:43:53,050
+مستوى عالي جدا بيكون male إذا كان مستوى منخفض أو
+
+571
+00:43:53,050 --> 00:44:00,970
+منعدم بيكون female لإن وجوده يسمح بإنشاء الأعضاء
+
+572
+00:44:00,970 --> 00:44:06,920
+الذكريةيمنع تكوين الأعضاء الجنثوية في المرحلة
+
+573
+00:44:06,920 --> 00:44:11,540
+الجنينية طبعاً الـ AMH has a different role for
+
+574
+00:44:11,540 --> 00:44:17,360
+female from or after puberty at the time of his
+
+575
+00:44:17,360 --> 00:44:21,020
+beginning making AMH the more egg cell there are
+
+576
+00:44:21,020 --> 00:44:25,400
+the high level of AMH ال AMH يمكن أن يستخدم as
+
+577
+00:44:25,400 --> 00:44:29,610
+marker or indicator for ovarian responseجدّيش أنا
+
+578
+00:44:29,610 --> 00:44:32,870
+عند مستوى الـ AMH عند السيدات جدّيش بكون عندها
+
+579
+00:44:32,870 --> 00:44:36,810
+مخزون في المبيض ففي علاقة طردية ما بين مستوى الـ
+
+580
+00:44:36,810 --> 00:44:40,950
+AMH ومخزون المبيض كل ما كان الـ AMH عالي، معناه
+
+581
+00:44:40,950 --> 00:44:45,570
+فيه بيبايدات كتير جدا عند السيدة الـ AMH يمكن أن
+
+582
+00:44:45,570 --> 00:44:50,710
+يستخدم ليه؟ predict for started monobios متى كل ما
+
+583
+00:44:50,710 --> 00:44:54,770
+كان قليل المنوبيوز بتكون أقرب يستخدم في تشخيص الـ
+
+584
+00:44:54,770 --> 00:44:57,530
+polycystic ovarian syndrome ال hormonal disorder
+
+585
+00:44:58,580 --> 00:45:02,840
+يستخدم في .. for infant .. infant .. chick infant
+
+586
+00:45:02,840 --> 00:45:06,260
+with genital that are not clear identified عند ال
+
+587
+00:45:06,260 --> 00:45:10,700
+male و female monitoring women who have some type
+
+588
+00:45:10,700 --> 00:45:15,000
+of ovarian cancer we can use it as indicator for
+
+589
+00:45:15,000 --> 00:45:18,640
+fertility in women specifically in relation to the
+
+590
+00:45:18,640 --> 00:45:25,740
+number of egg in reserve of ovaries so AMHcan be
+
+591
+00:45:25,740 --> 00:45:30,740
+used as indicator for ovarian response and ovarian
+
+592
+00:45:30,740 --> 00:45:34,440
+reserve
+
+593
+00:45:34,440 --> 00:45:40,540
+على مخزون المبيض ومدى استجابة المبيض so we can use
+
+594
+00:45:40,540 --> 00:45:44,160
+a match as a predictor for ovarian reserve and
+
+595
+00:45:44,160 --> 00:45:48,000
+ovarian response سوف نكتفي بهذا القدر في المحاضرة
+
+596
+00:45:48,000 --> 00:45:51,380
+اليوم على أن نكمل ما تبقى من هذا ال chapter في
+
+597
+00:45:51,380 --> 00:45:54,020
+المحاضرة القادمة ان شاء الله
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/N-8xgiNju1w_raw.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/N-8xgiNju1w_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..8ff46b231f78cd58e78decbdd9c80f2af0abbb90
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/N-8xgiNju1w_raw.srt
@@ -0,0 +1,1592 @@
+1
+00:00:00,960 --> 00:00:04,200
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:04,200 --> 00:00:09,020
+المرسلين سيدنا محمد وعلى آله وصاحبه أجمعين طلابنا
+
+3
+00:00:09,020 --> 00:00:12,720
+الأعزاء نرجو من الله الكريم أن تكونوا جميعا بخير و
+
+4
+00:00:12,720 --> 00:00:16,840
+بصحة جيدة استكمالا لما بدأنا فيه في المحاضرة
+
+5
+00:00:16,840 --> 00:00:21,080
+السابقة تحدثنا عن الآليات والطرق التي يمكن أن
+
+6
+00:00:21,080 --> 00:00:24,780
+تستخدم من أجل تحضير عينة السائل الحطن المجهري أو
+
+7
+00:00:24,780 --> 00:00:29,060
+التلقيح الصناعيواتطرحنا إلى ثلاث طرق أساسية طريقة
+
+8
+00:00:29,060 --> 00:00:32,560
+الأولى طريقة الـ Simple Washing Method طريقة تليها
+
+9
+00:00:32,560 --> 00:00:36,080
+طريقة الـ Swamp Up و الأكثر استخداما في حالة الـ
+
+10
+00:00:36,080 --> 00:00:39,840
+IOI أو الـ IVF الـ Traditional IVF و الطريقة
+
+11
+00:00:39,840 --> 00:00:43,060
+الثالثة هي عبارة عن الـ Density Gradient
+
+12
+00:00:43,060 --> 00:00:47,020
+Centrifugation and this method will be used in IGZ
+
+13
+00:00:47,020 --> 00:00:52,560
+or during IGZ process اليوم سوف نستكمل هذا الأمر
+
+14
+00:00:52,560 --> 00:00:57,220
+في التعرف على طرق أخرىيمكن من خلالها الحصول على
+
+15
+00:00:57,220 --> 00:01:03,060
+عينة السمن في حالات معينة تعتبر حالات مرضية تحت
+
+16
+00:01:03,060 --> 00:01:09,020
+مصطلح تيسا أو تيسي، بيسا أو ميسا شو معنى هذه
+
+17
+00:01:09,020 --> 00:01:14,960
+المصطلحات وما المقصود بها في المحاضرة السابقة
+
+18
+00:01:14,960 --> 00:01:20,540
+تكلمنا عن مصطلح asospermia وهو عدد عدم وجود
+
+19
+00:01:20,540 --> 00:01:25,040
+spermatozoa في السمن الفلويدوقُسمت Clinical من
+
+20
+00:01:25,040 --> 00:01:27,820
+ناحية كليكية إلى Obstructive وNon-obstructive
+
+21
+00:01:27,820 --> 00:01:31,740
+Azospermia والـ Obstructive Azospermia هي عبارة عن
+
+22
+00:01:31,740 --> 00:01:36,320
+عدم وجود سبرماتوزوة في السمن الفلويد بفعل خلل
+
+23
+00:01:36,320 --> 00:01:39,680
+ميكانيكي يسمى Mechanical Blockage في الـ Vase
+
+24
+00:01:39,680 --> 00:01:43,840
+Difference أو الـ Ejaculatory Duct أو الـ
+
+25
+00:01:43,840 --> 00:01:47,620
+Epidermis معناة تلاتة هدولة، تلاتة مناطق هذه فيها
+
+26
+00:01:47,620 --> 00:01:52,080
+Blockage فأثدت إلى عدم خروج لسبرماتوزوة من المصنع
+
+27
+00:01:53,210 --> 00:01:56,670
+قسموهم الـ Obstructive Azoospermia إلى Acquired و
+
+28
+00:01:56,670 --> 00:01:59,890
+Congenital الـ Acquired إن الإنسان كان طبيعي و
+
+29
+00:01:59,890 --> 00:02:03,470
+فجأة تعرض إلى حادث معين حدث عنده Obstructive
+
+30
+00:02:03,470 --> 00:02:07,490
+Azoospermia زي الـ Vasectomy الـ Post Infection
+
+31
+00:02:07,490 --> 00:02:12,150
+Disease Surgical Operation أو أي مشكلة في منطقة
+
+32
+00:02:12,150 --> 00:02:17,190
+الـ Abdominal أو منطقة الـ Pelvic أو صاروا Trauma
+
+33
+00:02:17,190 --> 00:02:18,670
+في منطقة الـ Reproductive System
+
+34
+00:02:21,980 --> 00:02:24,080
+الـ Congenital Obstructive Azoospermia الـ
+
+35
+00:02:24,080 --> 00:02:27,560
+Congenital Obstructive Azoospermia إن الطفل الذكر
+
+36
+00:02:27,560 --> 00:02:31,380
+يولد بعدم موجود لا إبداد مصر ولا Fast Difference
+
+37
+00:02:31,380 --> 00:02:36,380
+ولا Ejaculatory Duct أو واحد منهم مختفي أو بمعنى
+
+38
+00:02:36,380 --> 00:02:40,000
+آخر عنده مشكلة في الـ Prostatic Cyst أو مرحلة
+
+39
+00:02:40,000 --> 00:02:44,340
+بنسميها Young Syndrome طبعا هذا Genetic بشكل عام
+
+40
+00:02:44,340 --> 00:02:48,720
+وبشكل أساسي طبعا هذه هي عبارة عن الأسباب التي تؤدي
+
+41
+00:02:48,720 --> 00:02:52,610
+وتقصي وتقسيمات الـ Obstructive Azoospermiaأما
+
+42
+00:02:52,610 --> 00:02:55,490
+بالنسبة لتقسيمات الـ Non-obstructive Azospermia
+
+43
+00:02:55,490 --> 00:02:59,290
+فحكينا إن الـ Non-obstructive إن هذا الإنسان طبيعي
+
+44
+00:02:59,290 --> 00:03:03,050
+بكل نواقله المخصص بالـ Reproductive tract موجودة
+
+45
+00:03:03,050 --> 00:03:07,890
+وطبيعية ولكن تعرض إلى أمور أدت إلى حدوث خلل في
+
+46
+00:03:07,890 --> 00:03:11,510
+المصدر، في المصنع، في الـ Testis زي الـ Endocrine
+
+47
+00:03:11,510 --> 00:03:16,110
+abnormality زي الـ Genetic abnormality كرومزوم الـ
+
+48
+00:03:16,110 --> 00:03:18,570
+abnormality أنبلود الـ Translocation الـ Y
+
+49
+00:03:18,570 --> 00:03:20,550
+-microchromosome deletion abnormality في
+
+50
+00:03:20,550 --> 00:03:24,660
+الكاريوتيبلفي عنده post infection، في عنده trauma،
+
+51
+00:03:24,660 --> 00:03:28,020
+في عنده environment toxic exposure to radiation or
+
+52
+00:03:28,020 --> 00:03:30,740
+chemotherapy or radiotherapy exposure to heavy
+
+53
+00:03:30,740 --> 00:03:37,200
+metal and varicose veins this point أو هذه النقات
+
+54
+00:03:37,200 --> 00:03:41,660
+تعتبر من أكثر النقات التي تؤدي إلى حدوث non
+
+55
+00:03:41,660 --> 00:03:46,380
+-obstructive azospermia طيب السؤال اللي بترح نفسه
+
+56
+00:03:46,380 --> 00:03:50,870
+إنسان في عنده seminal fluidولكن بدون وجود
+
+57
+00:03:50,870 --> 00:03:56,470
+spermatozoa في السمن قد يكون obstructive و قد يكون
+
+58
+00:03:56,470 --> 00:04:00,070
+non-obstructive إذا كان obstructive الأمر بسيط
+
+59
+00:04:00,070 --> 00:04:05,930
+بعملية جروحية يعالج الأمر إذا كان هذا obstructive
+
+60
+00:04:05,930 --> 00:04:10,530
+إذا كان non-obstructive فبلجأ إلى الحصول على ال
+
+61
+00:04:10,530 --> 00:04:13,730
+spermatozoa من المصنع المباشرة يعني بمعنى آخر
+
+62
+00:04:13,730 --> 00:04:16,750
+طالما ال Epidermis موجود و ال vas deferens موجود
+
+63
+00:04:17,120 --> 00:04:21,760
+والتستش موجود قادر على إنتاج الـ spermatozoa ولكن
+
+64
+00:04:21,760 --> 00:04:25,260
+في عندها مشكلة ما بتقدر تخرج ال spermatozoa فبلجأ
+
+65
+00:04:25,260 --> 00:04:28,560
+إلى الوصول إلى ال spermatozoa بشكل مباشر و الحصول
+
+66
+00:04:28,560 --> 00:04:32,620
+عليها سواء كان في عندي obstructive أو في عندي non
+
+67
+00:04:32,620 --> 00:04:36,960
+-obstructive بشرط ما يكون عندي complete failure في
+
+68
+00:04:36,960 --> 00:04:40,120
+ال testicle function في ال non-obstructive ساعتها
+
+69
+00:04:40,120 --> 00:04:44,080
+بقدر أحصل على spermatozoa من المصنع طب كيف بحصل
+
+70
+00:04:44,080 --> 00:04:48,420
+على spermatozoa في تلت مصطلحات أساسيةبريكتانيوس
+
+71
+00:04:48,420 --> 00:04:56,860
+بيدمل sperm aspiration هذا بيسميها PECA PECA PECA
+
+72
+00:04:56,860 --> 00:04:59,460
+PECA PECA PECA PECA PECA PECA PECA PECA PECA PECA
+
+73
+00:04:59,460 --> 00:04:59,520
+PECA PECA PECA PECA PECA PECA PECA PECA PECA PECA
+
+74
+00:04:59,520 --> 00:04:59,520
+PECA PECA PECA PECA PECA PECA PECA PECA PECA PECA
+
+75
+00:04:59,520 --> 00:04:59,580
+PECA PECA PECA PECA PECA PECA PECA PECA PECA PECA
+
+76
+00:04:59,580 --> 00:05:02,400
+PECA PECA PECA PECA PECA PECA PECA PECA PECA PECA
+
+77
+00:05:02,400 --> 00:05:03,380
+PECA PECA PECA PECA PECA PECA PECA PECA PECA PECA
+
+78
+00:05:03,380 --> 00:05:11,600
+PECA PECA PECA PECA PECA
+
+79
+00:05:11,600 --> 00:05:15,820
+P
+
+80
+00:05:16,070 --> 00:05:19,970
+أختصار لـ testicular sperm aspiration وفي مصطلح
+
+81
+00:05:19,970 --> 00:05:23,770
+تاني بسميه TSA وهو عبارة عن testicular sperm
+
+82
+00:05:23,770 --> 00:05:28,610
+extraction أن أنا باخد sperm مباشرة بدون ما أعمل
+
+83
+00:05:28,610 --> 00:05:32,150
+aspiration طبعاً this is the method for harvest
+
+84
+00:05:32,150 --> 00:05:36,110
+sperm from the testicular in obstructed aspermia
+
+85
+00:05:36,110 --> 00:05:39,710
+يعني التلات مصطلحات هذه أو الأربعة هي المصطلحات
+
+86
+00:05:39,710 --> 00:05:43,290
+التي يمكن أن تستخدم للحصول و الوصول
+
+87
+00:05:47,440 --> 00:05:52,320
+obstructive azospermia يعني التستشغالة ولكن
+
+88
+00:05:52,320 --> 00:05:56,740
+النواقل فيها مشكلة in contrast, open testicular
+
+89
+00:05:56,740 --> 00:06:00,440
+sperm extraction تيسيه using single or multi
+
+90
+00:06:00,440 --> 00:06:06,420
+-biopsy and تيسيه with the aid of microsurgical R
+
+91
+00:06:06,420 --> 00:06:09,500
+-method to harvest sperm from man with non
+
+92
+00:06:09,500 --> 00:06:13,980
+-obstructive azospermia يعني بمعنى آخر أن ممكن أن
+
+93
+00:06:13,980 --> 00:06:17,930
+أعمل أكتر من biopsy في هذه الحالةإن تم فشل الـ
+
+94
+00:06:17,930 --> 00:06:21,190
+biopsy الأولى والـ biopsy التانية فالـ TSA هي
+
+95
+00:06:21,190 --> 00:06:26,230
+الأكثر استخداما أيضا في الـ non-obstructive
+
+96
+00:06:26,230 --> 00:06:30,950
+azoospermia الـ non-obstructive azoospermia تمام؟
+
+97
+00:06:30,950 --> 00:06:35,270
+مين هي؟ اللي هي سمناها microdissection testicular
+
+98
+00:06:35,270 --> 00:06:42,250
+sperm extraction أو micro TSA micro TSA صورة بتوضح
+
+99
+00:06:42,250 --> 00:06:47,400
+الكلام اللي أنا قلته خلّينا نبدأ من اليمينTC من
+
+100
+00:06:47,400 --> 00:06:52,580
+يمين أعلى الشاشة شايف أنا باخد بيوبسي tissue من ال
+
+101
+00:06:52,580 --> 00:06:57,440
+testis مباشرة التي تقابلها باخد aspiration من ال
+
+102
+00:06:57,440 --> 00:07:00,880
+fluid الموجود في ال testis الصورة السفلة على
+
+103
+00:07:00,880 --> 00:07:03,960
+اليمين باخد aspiration ال fluid من ال epidermis
+
+104
+00:07:03,960 --> 00:07:09,420
+واللي وراها باخد aspiration من ال epidermis ولكن
+
+105
+00:07:09,420 --> 00:07:14,580
+باختراق هنا في الأولى من الأسفل مباشرة ال needle
+
+106
+00:07:14,580 --> 00:07:19,750
+بتروح علىهي بتدمس يعني بيصير فتح بعملية جراحية أما
+
+107
+00:07:19,750 --> 00:07:22,870
+في التانية العليا الصالة أنا بقترق الجلد بدون
+
+108
+00:07:22,870 --> 00:07:28,130
+مفتاح ال testis و هنشوف كيف العملية بيهتم نجي
+
+109
+00:07:28,130 --> 00:07:33,690
+للمرة الأولى أو المصطلح الأول اللي سمته مي سا و بي
+
+110
+00:07:33,690 --> 00:07:38,490
+سا ال procedure to collect this step او this
+
+111
+00:07:38,490 --> 00:07:42,260
+method we used itأو الـ procedure for this method
+
+112
+00:07:42,260 --> 00:07:47,040
+we can use it to collect sperm from Epidermis عن
+
+113
+00:07:47,040 --> 00:07:50,860
+طريق الـ MESA و الـ PESA يعني الـ Epidermis أنا
+
+114
+00:07:50,860 --> 00:07:54,760
+بجمع منه spermatozoa كتكنولوجيس باستخدام طريقتين
+
+115
+00:07:54,760 --> 00:08:03,560
+طريقة بسميها MESA و PESA طريقة الأولى فيها فتحة
+
+116
+00:08:03,560 --> 00:08:08,360
+بتصير في ال testicularis و الطريقة التانيةبيصير عن
+
+117
+00:08:08,360 --> 00:08:10,440
+طريق الـ aspiration بدخول الـ needle وحنشوفها
+
+118
+00:08:10,440 --> 00:08:15,400
+بالصورة كمان شوية اذا fine needle is used to
+
+119
+00:08:15,400 --> 00:08:22,400
+puncture the epidermis and the epidermal fluid is
+
+120
+00:08:22,400 --> 00:08:27,840
+collected by fine gauge needle aspiration الميسة
+
+121
+00:08:27,840 --> 00:08:31,080
+طبعا هذه لما نقول fine needle بتخترق ال epidermis
+
+122
+00:08:31,080 --> 00:08:37,230
+وبتصير aspiration لل epidermal fluidإذا هدف طالما
+
+123
+00:08:37,230 --> 00:08:40,450
+فيها aspiration بسميها و بدون وجود فتحة جراحية
+
+124
+00:08:40,450 --> 00:08:47,070
+بسميها PSA Aspiration Spam Aspiration في ال MESA
+
+125
+00:08:47,070 --> 00:08:52,170
+بصير فتحة جراحية بسميها Open Surgical Spam
+
+126
+00:08:52,170 --> 00:08:56,350
+Retrovide Procedure that used an operating
+
+127
+00:08:56,350 --> 00:09:01,650
+microscopic to locate the tupule of the epidermis
+
+128
+00:09:01,650 --> 00:09:05,450
+يعني بمعنى أخر أنا بحدد ال epidermis و بعمل فتحة
+
+129
+00:09:05,700 --> 00:09:10,080
+جراحية في الغلاف المحيط بالتستس و بصل إلى ال
+
+130
+00:09:10,080 --> 00:09:13,680
+Epidermis عشان أعمل aspiration لل fluid الموجود
+
+131
+00:09:13,680 --> 00:09:18,520
+منه يعني ما بخترق ال skin و ما بعمل puncture لل
+
+132
+00:09:18,520 --> 00:09:22,120
+skin المحيط بالتستس بفعل needle من الخارج لأن أنا
+
+133
+00:09:22,120 --> 00:09:28,280
+بعمل فتحة جراحية فيها once they are located the
+
+134
+00:09:28,280 --> 00:09:32,540
+tupules are opened and the spermatic fluid that
+
+135
+00:09:32,540 --> 00:09:37,410
+follow out is aspiratedببساطة جدا يعني انا حددت
+
+136
+00:09:37,410 --> 00:09:41,990
+الـ Epidermis عملت فتحة جراحية بمشروط جراحي حددت
+
+137
+00:09:41,990 --> 00:09:45,330
+التيبيول اللي انا بده اسحب منه ال spermatozoa عملت
+
+138
+00:09:45,330 --> 00:09:47,790
+aspiration لل spermatozoa fluid او ال spermatic
+
+139
+00:09:47,790 --> 00:09:53,350
+fluid من منطقة ال Epidermis إذا كلا الطريقتين سواء
+
+140
+00:09:53,350 --> 00:09:57,510
+كانت الميسا أو البيسا بتصير في ال Epidermis
+
+141
+00:09:57,510 --> 00:10:04,720
+aspiration أو ال Epidermislocation او epidermis
+
+142
+00:10:04,720 --> 00:10:09,040
+part ولكن واحدة بتصير micro surgical واحدة بتصير
+
+143
+00:10:09,040 --> 00:10:14,740
+حاجة بتسميها puncture of the skin precontinuous
+
+144
+00:10:14,740 --> 00:10:21,440
+regardless for the approach of epidermal fluid is
+
+145
+00:10:21,440 --> 00:10:24,460
+placed on the petri dish and examined under the
+
+146
+00:10:24,460 --> 00:10:27,710
+microscope in vitro microscopeInverted Microscope
+
+147
+00:10:27,710 --> 00:10:31,610
+to confirm the presence of Motile Sperm سواء أنا
+
+148
+00:10:31,610 --> 00:10:35,850
+جمعت الـ Epidermal Fluid أو أفضل Epidermal Fluid
+
+149
+00:10:35,850 --> 00:10:39,330
+سواء جمعت Epidermal Fluid باستخدام الـ ESA أو الـ
+
+150
+00:10:39,330 --> 00:10:43,850
+PSA هذا ال Epidermal Fluid بوضعه في Petri dish و
+
+151
+00:10:43,850 --> 00:10:47,190
+بفحصه تحت ال Inverted Microscope على عدسة وقوة
+
+152
+00:10:47,190 --> 00:10:51,310
+تكبير 400X و بشوف هل يحتوى على Spermatozoa ولا لأ
+
+153
+00:10:51,310 --> 00:10:56,540
+بشرط أن تكون Motile Spermatozoaإذن هذا الفرق ما
+
+154
+00:10:56,540 --> 00:11:02,860
+بين ال PC و ال MESA ال PC أسبيراشن بشكل مباشر بدون
+
+155
+00:11:02,860 --> 00:11:06,300
+اختراق للجلد لفتحة جراحية أما ال MESA هي
+
+156
+00:11:06,300 --> 00:11:10,040
+Microsurgical أنا بعمل فتحة لفي الجلد طبعا هي أنا
+
+157
+00:11:10,040 --> 00:11:14,060
+شايف أدخل نيدل في الإبددمس مباشرة إذن هذا بسميه
+
+158
+00:11:14,060 --> 00:11:19,000
+Precutaneous Epidermal Sperm Aspirationعمل سكشة لـ
+
+159
+00:11:19,000 --> 00:11:23,580
+spermatozoa لـ spermatozoa او لإبّي dead male
+
+160
+00:11:23,580 --> 00:11:28,440
+fluid حطها
+
+161
+00:11:28,440 --> 00:11:31,400
+في petri dish وشافها تحت الـ inverted microscope
+
+162
+00:11:31,400 --> 00:11:35,600
+هل تحتوي على motile sperm ولا لأ طبعا إذا كانت
+
+163
+00:11:35,600 --> 00:11:39,140
+تحتوي إليها فعل وحدث وإذا كانت لا تحتوي إليها فعل
+
+164
+00:11:39,140 --> 00:11:44,440
+وحدث مغير ومختلف طبعا
+
+165
+00:11:44,440 --> 00:11:46,240
+بعد ما أقيسها
+
+166
+00:11:49,150 --> 00:11:54,650
+والله في sperm كافي ومافيش إذا في sperm كافي
+
+167
+00:11:54,650 --> 00:11:57,950
+مباشرة بعمل sperm washing أو بعمل gradient
+
+168
+00:11:57,950 --> 00:12:01,470
+centrifugation بناء على اللي أنا شو بده أعمل
+
+169
+00:12:01,470 --> 00:12:04,850
+بالعينة و الله إذا بده أعمل بالعينة I و I sperm أو
+
+170
+00:12:04,850 --> 00:12:08,190
+swarm up بتكفي إذا بده أعمل Xيه ال gradient مهم
+
+171
+00:12:08,190 --> 00:12:12,450
+جدا طب تصور إنه مافيش end sperm في العينة بس حتي
+
+172
+00:12:12,450 --> 00:12:17,790
+اللي بيدتمل fluid أو ال fluid الموجودفي الـ
+
+173
+00:12:17,790 --> 00:12:20,350
+Epidermis ما لاجدش فيه أندي كمية كافية من ال
+
+174
+00:12:20,350 --> 00:12:24,970
+spermatozoa إيش بده أعمل ساعتها مباشرة بلجأ إلى ال
+
+175
+00:12:24,970 --> 00:12:28,550
+M مايعرف اسم ال Microscopic Examination طبعا
+
+176
+00:12:28,550 --> 00:12:33,350
+عملتها مالاجدش كمية كافية بلجأ إلى ال MEC وهي
+
+177
+00:12:33,350 --> 00:12:37,750
+عبارة عن فتحة جراحية في الscortum بحدد اللوب الخاص
+
+178
+00:12:37,750 --> 00:12:42,650
+بال Epidermis و بعمل aspiration منه بشكله المباشر
+
+179
+00:12:42,650 --> 00:12:48,470
+والثاني إذا لاجدتالكمية طبعا الكافية و حضرت العينة
+
+180
+00:12:48,470 --> 00:12:51,370
+جزء من العينة بخليها تروح للحفن و الجزء التاني
+
+181
+00:12:51,370 --> 00:12:54,710
+بعملها freezing او ما يُعرف اسم ال
+
+182
+00:12:54,710 --> 00:13:00,110
+cryopreservation للمستقبل تمام؟ هذه الفرق ما بين
+
+183
+00:13:00,110 --> 00:13:06,110
+ال Pc و ال Mc for sperm aspiration or collection
+
+184
+00:13:06,110 --> 00:13:10,930
+from a bed moss خلينا نشوف الفيديو المتعلق بهذه
+
+185
+00:13:10,930 --> 00:13:11,450
+العملية
+
+186
+00:13:36,500 --> 00:13:37,900
+موسيقى
+
+187
+00:14:08,680 --> 00:14:10,080
+موسيقى
+
+188
+00:14:55,100 --> 00:14:57,000
+هو العملية اللي شبهت في الفيديو هي عبارة عن عملية
+
+189
+00:14:57,000 --> 00:15:00,760
+مصغرة تم فتح الجلد المحيط بالـ Testis ثم وصولا إلى
+
+190
+00:15:00,760 --> 00:15:05,360
+ال Epidermis طبعا فتح وعمل جروح في ال Epidermis
+
+191
+00:15:05,360 --> 00:15:08,140
+عشان يخرج السائل الموجود فيه المكازن فيه و بعدين
+
+192
+00:15:08,140 --> 00:15:11,420
+يعمله suction طالما أنا عملت بهذا الشكل و فيه فتحة
+
+193
+00:15:11,420 --> 00:15:15,500
+جراحية بسميها MS micro-surgical لو أنا دخلت ب
+
+194
+00:15:15,500 --> 00:15:18,700
+needle و بس اخترق الجلد عن طريق ال needle بدون
+
+195
+00:15:18,700 --> 00:15:23,040
+فتحة جراحية بسميها PC طبعا المنطق بقول إن أعمل PC
+
+196
+00:15:23,040 --> 00:15:28,660
+في الأول مالاجهش أعملهذه الفكرة الأساسية المتعلقة
+
+197
+00:15:28,660 --> 00:15:35,800
+بهذا الموضوع الطريقة التانية طريقة الـ TSA هي
+
+198
+00:15:35,800 --> 00:15:38,960
+عبارة عن طريقة يتم فيها عمل collection للـ
+
+199
+00:15:38,960 --> 00:15:42,700
+spermatozoa من المصنع مباشرة مش من مكان التخزين من
+
+200
+00:15:42,700 --> 00:15:46,140
+المصنع المباشرة يعني مقصود فيها من الـ testis so
+
+201
+00:15:46,140 --> 00:15:49,160
+the sample spermatozoa should be collected from
+
+202
+00:15:49,160 --> 00:15:53,380
+the testis either by testicular sperm aspirationor
+
+203
+00:15:53,380 --> 00:15:56,280
+testicular sperm extraction لما أقول aspiration
+
+204
+00:15:56,280 --> 00:15:58,980
+يعني أنا باخد fluid لما أقول extraction يعني أنا
+
+205
+00:15:58,980 --> 00:16:04,080
+باخد tissue he say samples are obtained with wide
+
+206
+00:16:04,080 --> 00:16:08,640
+pore needle pushed recontinuously into the testis
+
+207
+00:16:08,640 --> 00:16:11,740
+يعني في عندى needle هذه ال needle ال pores تبعتها
+
+208
+00:16:11,740 --> 00:16:16,760
+عريضة جدا بتتم اختراقها للجلد وصولا إلى ال testis
+
+209
+00:16:16,760 --> 00:16:20,980
+مجرد أنه اتصل لل testis بتتم عمل suction لل fluid
+
+210
+00:16:20,980 --> 00:16:25,830
+الموجود أو لجزءمن .. خلّيني أسأل .. إذا صح التعبير
+
+211
+00:16:25,830 --> 00:16:30,290
+لجزء من الـ tissue عمل suction عن طريق بنزع ال
+
+212
+00:16:30,290 --> 00:16:35,790
+tissue انتزاع بدون اختراق الجلد أنا بدخل needle و
+
+213
+00:16:35,790 --> 00:16:39,210
+ال needle هي اللي بتعمل catching ل ال biopsy أو ال
+
+214
+00:16:39,210 --> 00:16:41,750
+tissue ال testicular tissue و بتعملها عملية
+
+215
+00:16:41,750 --> 00:16:46,890
+extraction أما بالنسبة لل TC بال E لأ أنا بعمل
+
+216
+00:16:46,890 --> 00:16:50,670
+removingOpen technique that removes several pieces
+
+217
+00:16:50,670 --> 00:16:54,530
+of testis tissue بعدين باخد يعني بعمل فتحة جراحية
+
+218
+00:16:54,530 --> 00:16:59,470
+بصل ال testis وباخد منها نسيج اتنين تلاتة من اكتر
+
+219
+00:16:59,470 --> 00:17:04,690
+من منطقة TSA samples are evaluated for motile or
+
+220
+00:17:04,690 --> 00:17:08,210
+immotile spermatozoa with stereo microscope هناخد
+
+221
+00:17:08,210 --> 00:17:10,730
+إيش يعني stereo وإيش يعني inverted microscope
+
+222
+00:17:10,730 --> 00:17:14,940
+العين اللي أخدتها من ال testicular tissueأو
+
+223
+00:17:14,940 --> 00:17:18,400
+testicular biopsy سواء كانت باستخدام الـ TSA أو
+
+224
+00:17:18,400 --> 00:17:22,520
+الـ TSA بعمل إيه ما إلها عملية evaluation باستخدام
+
+225
+00:17:22,520 --> 00:17:26,880
+الـ stereomicroscope و بشوف هل تحتوى على motile أو
+
+226
+00:17:26,880 --> 00:17:30,360
+non motile sperm ولكن خدوا بالك طالما أنا آخر ما
+
+227
+00:17:30,360 --> 00:17:33,960
+أخد tissue لازم هذا ال tissue أقطعه بشكل كبير جدا
+
+228
+00:17:33,960 --> 00:17:37,620
+جدا جدا جدا أقطعه أكثر من مرة عشان يصير انديجيزيات
+
+229
+00:17:37,620 --> 00:17:41,920
+صغيرة جدا جدا جدا تم تسمح بخروج ال spermatozoa
+
+230
+00:17:41,920 --> 00:17:46,240
+اللي تكون محجوزة داخل هذاالـ tissue داخل هذا الـ
+
+231
+00:17:46,240 --> 00:17:51,260
+tissue طبعا هي عند الـ TSA بالـ A طالما بالـ A
+
+232
+00:17:51,260 --> 00:17:54,560
+يعني بعمل aspiration هاي ال needle اللي بتاع ..
+
+233
+00:17:54,560 --> 00:17:58,260
+اللي لها pores very wide دخلت من خلال ال testes
+
+234
+00:17:58,260 --> 00:18:04,920
+اخترقتها وصلت ل testicular عملت ضغط عن طريق high
+
+235
+00:18:04,920 --> 00:18:09,240
+pressure أو high push اخترقت ال TSA وأخدت منها
+
+236
+00:18:09,240 --> 00:18:12,960
+قطعة من النسيج هذه قطعة النسيج الموجودة في ال test
+
+237
+00:18:12,960 --> 00:18:18,240
+tubeبعملها عملية fragmentation أو بسميها عملية
+
+238
+00:18:18,240 --> 00:18:22,680
+section عن طريق ال forceps الحالي بقطعها قطع صغيرة
+
+239
+00:18:22,680 --> 00:18:26,800
+جدا جدا جدا حتى تسمح و بغسلها مرة و اتنين حتى تسمح
+
+240
+00:18:26,800 --> 00:18:30,860
+بخروج طبعا مش بغسلها بضيف عليها المحلول و بكبه لأ
+
+241
+00:18:30,860 --> 00:18:33,840
+ان بضيف عليها المحلول علشان تسمح بخروج ال
+
+242
+00:18:33,840 --> 00:18:39,250
+spermatozoa و بشوف هذا النسيج تحت ال microscopeبعد
+
+243
+00:18:39,250 --> 00:18:42,130
+كده بعملها عملية centrifugation عشان يتخلص من كل
+
+244
+00:18:42,130 --> 00:18:46,230
+fluid و ما يتخلص من كل ال tissue و يبقى ال fluid
+
+245
+00:18:46,230 --> 00:18:49,930
+اللي يحتوي على ال spermatozoon بعملها evaluation
+
+246
+00:18:49,930 --> 00:18:55,910
+فيما بعد طيب إذا عملت ال aspiration أو تسأل P سا
+
+247
+00:18:55,910 --> 00:18:59,350
+بالA aspiration و لجيت في عندك كمية كافية من ال
+
+248
+00:18:59,350 --> 00:19:04,250
+spermatozoon تحت ال inverted microscope ببدأ
+
+249
+00:19:04,250 --> 00:19:09,220
+أحضرهالعملية الحقن المجهوري من خلال الـ Density
+
+250
+00:19:09,220 --> 00:19:12,960
+Gradient Centrifugation و ببعتها للمختبر إذا كانت
+
+251
+00:19:12,960 --> 00:19:16,360
+العينة كافية و جزء منها بخزنه إذا كانت العينة لا
+
+252
+00:19:16,360 --> 00:19:20,720
+تحتوى على كمية كافية من الـ sperm metazoa تصلح
+
+253
+00:19:20,720 --> 00:19:25,000
+للإكزي يعني adequated sample for sperm for إكزي is
+
+254
+00:19:25,000 --> 00:19:28,660
+not enough بروح بعمل موضوع تاني وهو عبارة عن الـ
+
+255
+00:19:28,660 --> 00:19:34,230
+TC بالـ E وهو أنا باخد tissueمرة و مرتين و تلاتة
+
+256
+00:19:34,230 --> 00:19:39,610
+باستخدام micro operation .. micro surgical
+
+257
+00:19:39,610 --> 00:19:43,870
+operation في منطقة ال testis و باخد النسيج من اكثر
+
+258
+00:19:43,870 --> 00:19:48,370
+من منطقة من one side سواء كانت ال left او ال right
+
+259
+00:19:48,370 --> 00:19:52,970
+testis left او ال right testis خلينا نشوف الكلام
+
+260
+00:19:52,970 --> 00:19:57,970
+اللي كلمنا عنه و اللي متعلق بال TC او ال TC
+
+261
+00:20:12,620 --> 00:20:14,020
+أمريكا
+
+262
+00:20:22,830 --> 00:20:26,590
+طب نخدوا بالكوا هنا عمل فتحة جراحية في منطقة ال
+
+263
+00:20:26,590 --> 00:20:30,750
+testis وصل إلى الأنسجة المخلقة ال spermatozoa و
+
+264
+00:20:30,750 --> 00:20:33,770
+بدأ ياخد بيبس منها عن طريق عملية الانتزاع فهذه
+
+265
+00:20:33,770 --> 00:20:40,470
+عبارة عن TESE وليس TESE مافيها aspiration لأنه عمل
+
+266
+00:20:40,470 --> 00:20:43,190
+extraction ل testicular tissue
+
+267
+00:21:07,000 --> 00:21:08,400
+موسيقى
+
+268
+00:21:47,680 --> 00:21:50,640
+طبعا هنا بتكلم كيف بدي أعمل ال processing لعينة ال
+
+269
+00:21:50,640 --> 00:21:53,800
+testicular tissue في عينة محاضرة وشكتر كامل اللي
+
+270
+00:21:53,800 --> 00:21:57,520
+علاقة بال sample processing وكيف أنا بدي أعمل ال
+
+271
+00:21:57,520 --> 00:22:02,360
+spermatozoa تحت الميكروسكوب وفي عملية ال exudation
+
+272
+00:22:02,360 --> 00:22:02,780
+preparation
+
+273
+00:22:28,870 --> 00:22:33,070
+طبعا هذه العملية المتعلقة بالـ Tc بالـ A والـ Tc
+
+274
+00:22:33,070 --> 00:22:37,170
+بالـ E و الفرق ما بينهم و كيف أخد عينة الـ
+
+275
+00:22:37,170 --> 00:22:41,970
+testicular fluid و testicular tissue أيضا في حالة
+
+276
+00:22:41,970 --> 00:22:45,640
+ال micro operationوكيف بدأ يفحصها تحت ال inverted
+
+277
+00:22:45,640 --> 00:22:49,800
+microscope و ال stereo microscope علشان يتأكد فيها
+
+278
+00:22:49,800 --> 00:22:54,920
+spermatozoa ولا لأ هذه الفكرة ال testicular tissue
+
+279
+00:22:54,920 --> 00:23:00,020
+او ال epidermis fluid aspiration في حالة ال
+
+280
+00:23:00,020 --> 00:23:02,960
+obstructive و ال non-obstructive azosperma طب لو
+
+281
+00:23:02,960 --> 00:23:06,540
+انا قرنت بينهم على سبيل المثال بيسا بدها local
+
+282
+00:23:06,540 --> 00:23:11,850
+anesthesia يعني انك ك male يخضر تخضير موضعيفإنما
+
+283
+00:23:11,850 --> 00:23:17,190
+في الميسا في عملية جراحية تخضير كلي نسبة الحصول
+
+284
+00:23:17,190 --> 00:23:23,230
+على ال sperm 80% إلى 100% في الطريقة الأولى من 95%
+
+285
+00:23:23,230 --> 00:23:27,510
+إلى 100% في الطريقة التانية طبعا في الها
+
+286
+00:23:27,510 --> 00:23:33,410
+disadvantage مافي طريقة صحية وسليمة 100% كلها
+
+287
+00:23:33,410 --> 00:23:36,150
+advantage لأ في disadvantage فالطريقة الأولى
+
+288
+00:23:36,150 --> 00:23:41,350
+disadvantage هيماتوما بيظهر عندىفي فرصة للمحصولة
+
+289
+00:23:41,350 --> 00:23:44,590
+على كمية كافية من الـ spermatozoa بالإضافة إلى can
+
+290
+00:23:44,590 --> 00:23:48,990
+induce epidermal obstruction ممكن يبدأ لها أما
+
+291
+00:23:48,990 --> 00:23:52,510
+الميسا required operation room and micro surgical
+
+292
+00:23:52,510 --> 00:23:55,710
+scale يعني عملية جراحية حتى لو كانت عملية جراحية
+
+293
+00:23:55,710 --> 00:24:01,770
+صغيرة لو أنا قرنت ما بين ال Tc و Tc طبعا الأولى
+
+294
+00:24:01,770 --> 00:24:04,810
+طالما aspiration local واناستيزيا التانية طالما
+
+295
+00:24:04,810 --> 00:24:08,660
+operation generalالكمية الـ spermatozoa التي يمكن
+
+296
+00:24:08,660 --> 00:24:12,520
+أن نحصل عليها بالطريقة الأولى 52% إلا 100% أما
+
+297
+00:24:12,520 --> 00:24:15,800
+الطريقة التانية 100% عشان كده اللي هتبقى بالجائلة
+
+298
+00:24:15,800 --> 00:24:20,540
+بشكل عام ولكن مشكلتها أنها very painful شغلة تانية
+
+299
+00:24:20,540 --> 00:24:23,820
+أن النسيج اللي بتاخده مايرجع بيه المتاني بيصير
+
+300
+00:24:23,820 --> 00:24:26,800
+تليف في هذا المنطقة يعني كأنه منطقة بتموت
+
+301
+00:24:26,800 --> 00:24:31,320
+disadvantage hematomaكمية قليلة جدا من الـ
+
+302
+00:24:31,320 --> 00:24:33,800
+spermatosis و ممكن نحصل عليها بالطريقة الأولى أما
+
+303
+00:24:33,800 --> 00:24:37,360
+الطريقة التانية ال risk of testicular atrophy and
+
+304
+00:24:37,360 --> 00:24:40,320
+hypo functional في عند ال risk أنه يصير عندي hypo
+
+305
+00:24:40,320 --> 00:24:44,360
+functional في ال testis تحتاج إلى غرفة جراحية،
+
+306
+00:24:44,360 --> 00:24:48,880
+تحتاج إلى معدات، تحتاج إلى اهتمام بشكل كبير جدا
+
+307
+00:24:48,880 --> 00:24:54,500
+جدا جدا خلال عملية الاستشفاء خلال عملية الاستشفاء
+
+308
+00:24:55,960 --> 00:24:58,860
+طبعاً الـ spermatozoa حصلنا عليها باستخدام
+
+309
+00:24:58,860 --> 00:25:02,640
+testicular biopsy، كيف نتأكد أن هذا الحيوان المنوي
+
+310
+00:25:02,640 --> 00:25:06,640
+اللي حصلنا عليه حي؟ لأن عملية الحقن يجب أن تحدث
+
+311
+00:25:06,640 --> 00:25:10,600
+باستخدام life spermatozoa، مش أي حيوان منوي أنا
+
+312
+00:25:10,600 --> 00:25:13,970
+باستخدمه في عملية الحقنلازم يكون أقل شيء live
+
+313
+00:25:13,970 --> 00:25:19,610
+فممكن أنا أفحصه باستخدام فحص بتسميه hypo osmotic
+
+314
+00:25:19,610 --> 00:25:22,630
+swelling test اللي سمته host test واتكلمنا عنه في
+
+315
+00:25:22,630 --> 00:25:26,790
+المرحلة السابقة إن أنا بضيف ال spermatozoa اللي
+
+316
+00:25:26,790 --> 00:25:30,410
+أنا طلعتها فيه محلولهو عبارة عن hypotonic solution
+
+317
+00:25:30,410 --> 00:25:34,170
+وبشوف ال tail الخاص بهذا ال sperm صاله swelling
+
+318
+00:25:34,170 --> 00:25:37,070
+ولا لأ والله إذا صاله swelling ال end of tail
+
+319
+00:25:37,070 --> 00:25:40,690
+معناه هذا ال sperm متزوه استجاب واتفاعل مع المحلول
+
+320
+00:25:40,690 --> 00:25:44,970
+إذا هذا ال sperm متزوه أو ال sperm حي يمكن أن
+
+321
+00:25:44,970 --> 00:25:50,850
+يستخدم ومهم جدا أنه يتم غسل ال sperm الحي بعد
+
+322
+00:25:50,850 --> 00:25:54,930
+تعريضه لل hypo osmotic solution ب fresh mediaعلشان
+
+323
+00:25:54,930 --> 00:25:59,550
+يتخلص من المحلول اللي دخل على هذا ال sperm هذه
+
+324
+00:25:59,550 --> 00:26:05,810
+العملية فقط بتحتاج إلى 20 دقيقة ثانية على حد أعلى
+
+325
+00:26:05,810 --> 00:26:10,510
+أثناء استخدام وفحص ال spermatozoon هل هو حي أم لأ
+
+326
+00:26:10,510 --> 00:26:15,710
+من أجل إخضاعه وإشراكه في عملية الحقن الميجاري هذه
+
+327
+00:26:15,710 --> 00:26:19,890
+الشكل اللي بقصود فيه تلاقي ال sperm في عنده هذا ال
+
+328
+00:26:19,890 --> 00:26:22,630
+sperm dead هذا ال sperm اللي في نهاية التل فيه
+
+329
+00:26:22,630 --> 00:26:27,260
+عنده انتفارأو انتفاخ معناه أن الـ sperm حي يصلح أن
+
+330
+00:26:27,260 --> 00:26:31,360
+يستخدم في عملية الحقن الميجاري في طريقة تانية
+
+331
+00:26:31,360 --> 00:26:35,400
+طريقة ال sperm tail flexibility test ان انا بشوف
+
+332
+00:26:35,400 --> 00:26:38,980
+هل ال sperm flexible ولا مش flexible كيف انا بده
+
+333
+00:26:38,980 --> 00:26:43,860
+اقيصه لبساطة جدا ان using micro injection pipette
+
+334
+00:26:44,520 --> 00:26:48,680
+up morphological normal in motile sperm from sperm
+
+335
+00:26:48,680 --> 00:26:52,400
+micro drop and transferred to the PPV solution
+
+336
+00:26:52,400 --> 00:26:57,120
+يعني تحت الميكروسكوب أي sperm مش متحرك ولكن
+
+337
+00:26:57,120 --> 00:27:01,040
+morphological normal بسحبه وبنقله لقطرة جديدة
+
+338
+00:27:01,040 --> 00:27:05,320
+بنقله لبتردش جديد بنقله لبتردش يحتوي على media
+
+339
+00:27:05,320 --> 00:27:09,180
+بسميها PVP media خدوا بالكوا من هذه ال media
+
+340
+00:27:09,180 --> 00:27:13,420
+هنتكلم عنها بشكل مستفيد شو هي ال media وشو أهميتها
+
+341
+00:27:14,360 --> 00:27:17,860
+ببساطة جدا مش هنتكلم عنها اليوم ولكن من أحد
+
+342
+00:27:17,860 --> 00:27:21,760
+أهميتها أن تبقى طبق الحيوان المنوي في ظروف طبيعية
+
+343
+00:27:21,760 --> 00:27:25,620
+هنتكلم اللي هي وظائف أخرى اللي هي علاقة بطريقة
+
+344
+00:27:25,620 --> 00:27:30,300
+التعامل وإخفاء حركة الحيوان المنوي ولكن ببساطة
+
+345
+00:27:30,300 --> 00:27:33,460
+شوفت هذا الحيوان المنوي normal form ولكن non
+
+346
+00:27:33,460 --> 00:27:36,540
+-mutation بعمله aspiration و بلقله في petri dish
+
+347
+00:27:36,540 --> 00:27:42,840
+يحتوي على ميديا اسم PVP Media بعد كده باجي بطرف ال
+
+348
+00:27:42,840 --> 00:27:47,740
+injection needleبعمل touching للـ sperm with the
+
+349
+00:27:47,740 --> 00:27:50,940
+tip of micro injection pipet and forces the tail
+
+350
+00:27:50,940 --> 00:27:55,320
+to move up and down يعني بمعنى أخر باجي في نهاية
+
+351
+00:27:55,320 --> 00:28:00,160
+الـ tail الخاص بالـ sperm بدفع الـ sperm للأعلى أو
+
+352
+00:28:00,160 --> 00:28:05,160
+بدفع للأسفل وبشوف هل الـ sperm الـ tail الخاص بالـ
+
+353
+00:28:05,160 --> 00:28:08,660
+sperm فيه رد فعل ولا لا tail is considered
+
+354
+00:28:08,660 --> 00:28:12,020
+flexible when it moves independent of sperm head
+
+355
+00:28:12,530 --> 00:28:16,210
+بمعنى آخر إذا كان الـ sperm flexible الـ tail
+
+356
+00:28:16,210 --> 00:28:20,730
+الخاص بالـ sperm flexible هلاجي أن الـ head بتحرك
+
+357
+00:28:20,730 --> 00:28:24,430
+في اتجاه و الـ tail بتحرك في اتجاه آخر يعني بمعنى
+
+358
+00:28:24,430 --> 00:28:28,730
+آخر حركة الـ they لا تعتمد على حركة الـ head يعني
+
+359
+00:28:28,730 --> 00:28:33,050
+منفصلين منفصلين so sperm tail flexible is
+
+360
+00:28:33,050 --> 00:28:35,930
+considered a marker or indicator of sperm
+
+361
+00:28:35,930 --> 00:28:40,010
+viability إذا والله أنا أخدت هذا الـ sperm أتزوه
+
+362
+00:28:40,460 --> 00:28:43,860
+وحطته في طبق تحتوي على ال pvp media وجبت ال
+
+363
+00:28:43,860 --> 00:28:47,660
+injection needle وحركت نهاية ال sperm tail ولاجيت
+
+364
+00:28:47,660 --> 00:28:51,480
+أن ال sperm بتحرك في جهة و ال head بتحرك في جهة
+
+365
+00:28:51,480 --> 00:28:56,600
+معناه هذا أن ال sperm flexible ال tail لهذا ال
+
+366
+00:28:56,600 --> 00:29:01,860
+sperm flexible معناه أن ال sperm هذا حي الله يصلح
+
+367
+00:29:01,860 --> 00:29:05,640
+عملية الحقن المجاني والله لو انا حركته ولاجيت ال
+
+368
+00:29:05,640 --> 00:29:10,040
+tail و ال head بتحركوا مع بعض في اتجاه واحدمعناه
+
+369
+00:29:10,040 --> 00:29:14,080
+إن هذا الـ sperm non-flexibility دبعته equal zero
+
+370
+00:29:14,080 --> 00:29:18,240
+فلا يمكن أن يستخدم في الحقن المجاري if the tail
+
+371
+00:29:18,240 --> 00:29:21,860
+remain bridge upon touching and sperm head and
+
+372
+00:29:21,860 --> 00:29:25,940
+tail move together as one unit this sperm .. the
+
+373
+00:29:25,940 --> 00:29:28,680
+flexibility of this sperm equal zero and we cannot
+
+374
+00:29:28,680 --> 00:29:35,400
+be used for exit إذن الديل والديل بعد عملية اللمس
+
+375
+00:29:35,400 --> 00:29:39,270
+باستخدام ال injection needleتحرك بشكل مستقل عن
+
+376
+00:29:39,270 --> 00:29:42,550
+الهد يعني كلاهم في اتجاه المختلفين إذا هذا الحيوان
+
+377
+00:29:42,550 --> 00:29:47,430
+المنوي حي يمكن استخدامه الذير والهد تحركوا كقطلة
+
+378
+00:29:47,430 --> 00:29:50,790
+واحدة واحدة واحدة في اتجاه واحد إذا لا يمكن
+
+379
+00:29:50,790 --> 00:29:57,710
+استخدامه في عملية الحقن هذا ما يتعلق بمحاضرة اليوم
+
+380
+00:29:57,710 --> 00:30:01,770
+كيف يمكن الحصول على ال spermatozoa باستخدام ال
+
+381
+00:30:01,770 --> 00:30:05,770
+testicular biopsy بالأنواع الثلاثة المختلفة كيف
+
+382
+00:30:06,160 --> 00:30:11,540
+يمكن فحص الحيوان المنوي بعد ما أنا أحضره و أستخلصه
+
+383
+00:30:11,540 --> 00:30:15,340
+من النسيج هل هو mutile ولا non-mutile واللي أهم من
+
+384
+00:30:15,340 --> 00:30:19,000
+كده هل هو life ولا non-life ولا non-life or dead
+
+385
+00:30:19,000 --> 00:30:23,540
+sperm لأنه مهم جدا أن أعمل عملية الحقن باستخدام
+
+386
+00:30:23,540 --> 00:30:29,420
+life sperm, no dead sperm we cannot be used dead
+
+387
+00:30:29,420 --> 00:30:34,950
+sperm during IGZ or in IGZ processفممكن أنا بعد ال
+
+388
+00:30:34,950 --> 00:30:38,210
+testicular biopsy ألاقي كل الحيوانات المنوية non
+
+389
+00:30:38,210 --> 00:30:42,790
+-motile ما أفقد الثقة و أفقد الفرصة بقول ممكن يكون
+
+390
+00:30:42,790 --> 00:30:47,350
+non-motile ولكنه life فبأخد هذه ال normal form non
+
+391
+00:30:47,350 --> 00:30:51,250
+-motile spermatozoa و بعرضها لل hypotonic solution
+
+392
+00:30:51,250 --> 00:30:54,850
+أو بعملها flexibility test و أشوف هل ال sperm tail
+
+393
+00:30:54,850 --> 00:30:59,590
+بتحرك في اتجاه ال head tail كوحدة واحدة أو في
+
+394
+00:30:59,590 --> 00:31:02,490
+اتجاهين مختلفينإذا كانوا في اتجاهين مختلفين is a
+
+395
+00:31:02,490 --> 00:31:05,950
+life sphere, we can use it during or exit process
+
+396
+00:31:05,950 --> 00:31:09,370
+or exit operation إذا كانوا بتحركوا كوحدة واحدة لا
+
+397
+00:31:09,370 --> 00:31:12,970
+يمكن استخدامه يكفي في هذا القدر من المعلومات في
+
+398
+00:31:12,970 --> 00:31:17,630
+هذه المحاضرة على أمل أن نلتقي دائما بخير وعلى خير
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/UpgBJG4XVfA_raw.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/UpgBJG4XVfA_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f993bd88a8d204fb7eeeaf4077e6e2f227890990
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/UpgBJG4XVfA_raw.srt
@@ -0,0 +1,2684 @@
+1
+00:00:00,000 --> 00:00:05,240
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:05,240 --> 00:00:11,080
+المرسلين سيدنا محمد وعلى آله وصحبه أجمعين طلابنا
+
+3
+00:00:11,080 --> 00:00:15,240
+الأعزاء نرجو من الله الكريم أن تكونوا جميعا بخير
+
+4
+00:00:15,240 --> 00:00:21,760
+وبصحة جيدة اليوم سوف ننتقل إلى مربع جديد يعتبر جزء
+
+5
+00:00:21,760 --> 00:00:27,130
+أساسيا من عمليات الحقن المجهريوالذي سوف يتحدث عن
+
+6
+00:00:27,130 --> 00:00:31,050
+تحفيز المبيض لدى السيدات تحت مصطلح stimulation
+
+7
+00:00:31,050 --> 00:00:35,490
+protocol ثم ننتقل إلى أنواع ال media التي تستخدم
+
+8
+00:00:35,490 --> 00:00:40,030
+من أجل انضاج البوايضة إذا كانت البوايضة غير ناضجة
+
+9
+00:00:40,030 --> 00:00:45,590
+لحظة السحب أو وضع البوايضة المخصبة في media معينة
+
+10
+00:00:45,590 --> 00:00:51,710
+بناء على أيام انقسامها عملية stimulation protocol
+
+11
+00:00:51,710 --> 00:00:57,310
+مهمة جدا في عمليات الحقن المجهريومن خلال عملية
+
+12
+00:00:57,310 --> 00:01:02,830
+تحفيظ المبيض نصل إلى عدد معين من البويضات التي
+
+13
+00:01:02,830 --> 00:01:07,870
+ينبغي أن تكون ناضجة وينبغي أن تكون صالح للإخصاد
+
+14
+00:01:07,870 --> 00:01:12,890
+بأن تكون تحتوي على first polar body اليوم سوف
+
+15
+00:01:12,890 --> 00:01:18,010
+نتحدث عن هذه البروتوكولات المختلفة وكيف وما هي وما
+
+16
+00:01:18,010 --> 00:01:23,490
+اختلاف ما بين هذه البروتوكولات في البدايةفي بدايات
+
+17
+00:01:23,490 --> 00:01:27,730
+عملية التلقيح الصناعي أو عملية التلقيح الصناعي
+
+18
+00:01:27,730 --> 00:01:32,770
+المعترف بيها اسم In vitro fertilization يعني أطفال
+
+19
+00:01:32,770 --> 00:01:38,530
+النبيب كان هناك حالات يحدث فيها حمل ولكن من أجل
+
+20
+00:01:38,530 --> 00:01:44,390
+زيادة فرصة نجاح عملية التلقيح الصناعي وزيادة فرصة
+
+21
+00:01:44,390 --> 00:01:49,370
+وجود حمل ونجاح عملية التلقيح يجب علينا أن نصل إلى
+
+22
+00:01:49,370 --> 00:01:53,790
+مرحلةوهي مرحلة الحصول على أكبر عدد من البويضات
+
+23
+00:01:53,790 --> 00:02:00,090
+النادجة من أجل ضمان إلى حد ما نجاح عملية الحقن أو
+
+24
+00:02:00,090 --> 00:02:07,130
+التلقيح الصناعي فبالتالي من أجل تحسين عملية الحقن
+
+25
+00:02:07,130 --> 00:02:13,090
+ومن أجل تحسين معدل الحقن ومن أجل تحسين معدلحدوث
+
+26
+00:02:13,090 --> 00:02:18,810
+عملية الحمل pregnancy rate يجب علينا أن نسحب ونجمع
+
+27
+00:02:18,810 --> 00:02:23,490
+أكبر عدد من البويضات الناضجة التي تكون صالحة
+
+28
+00:02:23,490 --> 00:02:27,250
+لعملية الإخصاد فالبويضة الناضجة تكون صالحة لعملية
+
+29
+00:02:27,250 --> 00:02:31,790
+الإخصاد إذا كانت على شكل بويضة تحتوي على fairest
+
+30
+00:02:31,790 --> 00:02:36,510
+polar body فهذه العملية التي يتم من خلال تحسين
+
+31
+00:02:36,510 --> 00:02:42,160
+وزيادة عدد البويضات المسعوبة يتم من خلالحث المبيض
+
+32
+00:02:42,160 --> 00:02:47,740
+على إنتاج أكبر عدد من خلال تحفيزه بهرمونات خارجية
+
+33
+00:02:47,740 --> 00:02:52,560
+أو داخلية تشبه الهرمونات التي تعمل على المبيض من
+
+34
+00:02:52,560 --> 00:02:55,520
+أشهر الهرمونات التي تعمل على المبيض بناء على ما
+
+35
+00:02:55,520 --> 00:03:01,580
+دراسنا ال FSH و ال LH فبالتالي أنا كإنسان بشتغل في
+
+36
+00:03:01,580 --> 00:03:05,840
+ال emperiologist بدي أعمل تحفيز للمبيض و غادر طبعا
+
+37
+00:03:05,840 --> 00:03:08,400
+الطبيب هو اللي بحدد ال dose بناء على ال history
+
+38
+00:03:08,400 --> 00:03:13,330
+باستخدامExogenous أو Endogenous هرمون في الغالب
+
+39
+00:03:13,330 --> 00:03:17,770
+بيكون FSH في الغالب بيكون FSH أو ما يُعرف باسم
+
+40
+00:03:17,770 --> 00:03:22,550
+Gonadotropin والـ Gonadotropin هما نوعين FSH و LH
+
+41
+00:03:22,550 --> 00:03:27,790
+خلال السنوات المتعاقبة التي تتعلق بعمليات الحقن
+
+42
+00:03:27,790 --> 00:03:31,670
+المجهري والتلقيح الصناعيوجد هناك العديد من ال
+
+43
+00:03:31,670 --> 00:03:35,670
+protocolات التي يمكن استخدامها وكل ال protocol له
+
+44
+00:03:35,670 --> 00:03:39,270
+advantage و له disadvantage فلا يمكن استخدام
+
+45
+00:03:39,270 --> 00:03:43,290
+protocol واحد لجميع السيدات فبالتالي كل حالة
+
+46
+00:03:43,290 --> 00:03:48,070
+مستقلة عن الأخرى ولها protocol خاص فيها أول من
+
+47
+00:03:48,070 --> 00:03:52,590
+استخدم عملية ال protocols وعملية تحفيز المبيض كان
+
+48
+00:03:52,590 --> 00:03:58,190
+Porterزملاءه هما استخدموا ما يسمى الـ Gonadotropin
+
+49
+00:03:58,190 --> 00:04:02,650
+Releasing Hormone Agonist في عملية الـ IV Epi
+
+50
+00:04:02,650 --> 00:04:07,350
+Treatment فهو أول من استخدم عملية حقن السيدات
+
+51
+00:04:07,350 --> 00:04:13,130
+بغرمونات خارجية من أجل تحفيز المبيض تحت مصطلح GnRa
+
+52
+00:04:13,130 --> 00:04:17,790
+Agonist أي Gonadotropin Releasing Hormone Agonist
+
+53
+00:04:17,790 --> 00:04:22,730
+هذا كان أول واحد فيما يلي تعاقبة الأحداث وتتاليت
+
+54
+00:04:23,160 --> 00:04:27,520
+وتم تطوير قعدة البروتوكولات تقليديًا تطوير عدد
+
+55
+00:04:27,520 --> 00:04:32,420
+مرتبط أوسايت كان ممكنًا فقط بعد تطوير التحكم
+
+56
+00:04:32,420 --> 00:04:37,900
+التسلسلي أوفريانية بمعنى آخر يمكن للسيدة أن تعطي
+
+57
+00:04:37,900 --> 00:04:41,700
+عدد كبير جدًا من البويضات أكبر من الوضع الطبيعي
+
+58
+00:04:41,700 --> 00:04:45,480
+جعلنا في الوضع الطبيعي واحدة تنتين تلاتة بويضة
+
+59
+00:04:45,480 --> 00:04:50,580
+بينما إذا خضعت لمصطلح يسمى COS وهو عبارة عن
+
+60
+00:04:50,580 --> 00:04:54,740
+Controlled Ovarian Stimulationحطيط عدد كبير من
+
+61
+00:04:54,740 --> 00:05:00,000
+البوايدات قد يصل إلى 25 بوايدة وبعض الحالات تصل
+
+62
+00:05:00,000 --> 00:05:05,100
+إلى 35 بوايدة طبعا للأسف كلهم مش ناضج ولكن أقل شئ
+
+63
+00:05:05,100 --> 00:05:09,460
+تلتينه بيكون ناضجين شو يعني Controlled Ovarian
+
+64
+00:05:09,460 --> 00:05:12,680
+Hyperstimulation Protocol؟ هو عبارة عن نظام
+
+65
+00:05:12,680 --> 00:05:17,540
+وبروتوكول يستخدم فيه هرمونات تعمل على تحفيز المبيض
+
+66
+00:05:17,810 --> 00:05:22,350
+ولكن تحت عملية السيطرة ما بيغرد المبرة .. المبية
+
+67
+00:05:22,350 --> 00:05:26,450
+تخرج السرب و بيصير يشتغل من تلقاء نفسه ما بيصير
+
+68
+00:05:26,450 --> 00:05:32,670
+عندي hyper response لأ ال response بيكون محكم ..
+
+69
+00:05:32,670 --> 00:05:37,970
+انا ك technologist او ك imperialist متحكم فيه بناء
+
+70
+00:05:37,970 --> 00:05:41,870
+على ال dose اللي بعطيها للسيدة طبعا في الوضع
+
+71
+00:05:41,870 --> 00:05:46,460
+الطبيعي و في الدورة الشهرية الطبيعية تنموعدت من
+
+72
+00:05:46,460 --> 00:05:51,280
+الـAnterior Follicle الموجودة في المبيض ولكن ما
+
+73
+00:05:51,280 --> 00:05:55,540
+يصل إلى الـGrafian Follicle وهي لحظة الـ ovulation
+
+74
+00:05:55,540 --> 00:05:59,460
+واحدة، اتن، تلاتة ماكسيما الـ interaction between
+
+75
+00:05:59,460 --> 00:06:03,040
+growing follicle and pituitary gland and
+
+76
+00:06:03,040 --> 00:06:06,620
+hypothalamus prevented multifollicle growth and
+
+77
+00:06:06,620 --> 00:06:10,140
+allowed only one follicle complete maturation and
+
+78
+00:06:10,140 --> 00:06:13,400
+arrive to the stage of ovulation إيش اللي بيخلي
+
+79
+00:06:13,630 --> 00:06:16,790
+المبيض في الوضع الطبيعي ما بيطلّع أكتر من تلت
+
+80
+00:06:16,790 --> 00:06:20,350
+بويضات أو بويضتين كحد أقصى إنه في عندي نوع من
+
+81
+00:06:20,350 --> 00:06:23,370
+أنواع ال correlation نوع من أنواع ال interaction
+
+82
+00:06:23,370 --> 00:06:27,850
+نوع من أنواع ال connection ما بين ال hypothalamus
+
+83
+00:06:27,850 --> 00:06:32,230
+كmaster و ال pituitary gland التي تفرز الأفسح
+
+84
+00:06:32,230 --> 00:06:36,590
+والأدش و ال growing follicle فهذه الهرمونات اللي
+
+85
+00:06:36,590 --> 00:06:40,140
+بتكون رايحة جاية بين التلت مناطق هذههي اللي بتتحكم
+
+86
+00:06:40,140 --> 00:06:43,340
+في عمل المبيض و بتقول المبيض يكفي إنتاج بوايض
+
+87
+00:06:43,340 --> 00:06:47,960
+تانية أو ثلاثة كحد أقصى في الوضع الطبيعي لأن هذا
+
+88
+00:06:47,960 --> 00:06:52,020
+شغل هرمونات كل ما زاد هرمون ال FSH كل ما زاد معدل
+
+89
+00:06:52,020 --> 00:06:57,840
+نضوج البوايض و هكذا فبالتالي control ovarian
+
+90
+00:06:57,840 --> 00:07:02,100
+stimulation required multiply tele injection and
+
+91
+00:07:02,100 --> 00:07:05,620
+frequently monitoring scanning that creating
+
+92
+00:07:05,620 --> 00:07:08,580
+directly and indirectly caused lose of working
+
+93
+00:07:08,580 --> 00:07:14,280
+timeللأسف وجدوا أن عملية تحفيظ المبيض المتحكم به
+
+94
+00:07:14,280 --> 00:07:18,460
+مسمى Control Ovarian Hyper Stimulation يتم من خلال
+
+95
+00:07:18,460 --> 00:07:23,400
+إعطاء الزوجة أو إعطاء السيدة جرعات متتالية ويومية
+
+96
+00:07:23,400 --> 00:07:28,460
+من الهرمونات بشكل متتالي تكون هذه الجرعات تحت
+
+97
+00:07:28,460 --> 00:07:32,720
+السيطرة وتحت المراقبة بالإضافة إلى مراقبة وظهر
+
+98
+00:07:32,720 --> 00:07:37,320
+المبيضو الـ Diameter الخاصة بالفوليكيد ولكن للأسف
+
+99
+00:07:37,320 --> 00:07:40,860
+وجدوا أن هذه العملية عملية بالشكل العام متعبة
+
+100
+00:07:40,860 --> 00:07:47,880
+مرهقة مكلفة إضافة إلى أنها مضيعة للوقت في النظام
+
+101
+00:07:47,880 --> 00:07:52,240
+العالمي اللي يعتمد على أن الشخص يشتغل 8 ساعات
+
+102
+00:07:52,240 --> 00:07:56,120
+يوميا أو 9 ساعات يوميا فإذا هذه السيدة كانت عاملة
+
+103
+00:07:56,120 --> 00:08:00,280
+تشتغل في وظيفة معينة فبدت تخضع لل control of
+
+104
+00:08:00,280 --> 00:08:04,910
+various stimulationمن الراحة إلى حد ما عدم الإجهاد
+
+105
+00:08:04,910 --> 00:08:08,350
+فبالتالي هتخسر من ساعات أو هتقلل من ساعات دوامها
+
+106
+00:08:08,350 --> 00:08:12,190
+فبالتالي الإنتاج بتأثر عشان كده قالوا إنه يؤثر على
+
+107
+00:08:12,190 --> 00:08:18,430
+عدد ساعات العمل بشكل مباشر أو غير مباشر ولكن
+
+108
+00:08:18,430 --> 00:08:22,970
+المشكلة الأساسية هي مشكلة مادية فوجدوا إن الناس
+
+109
+00:08:22,970 --> 00:08:26,510
+والسيدات اللي بتخضع لدى ال protocol بدفع كميات
+
+110
+00:08:26,510 --> 00:08:30,960
+مهولة من الأموال فبالتالي بتكون عندى عبق ماليعلى
+
+111
+00:08:30,960 --> 00:08:35,560
+هذه العائلة The most important medical problem
+
+112
+00:08:35,560 --> 00:08:39,480
+associated with control ovarian stimulation is the
+
+113
+00:08:39,480 --> 00:08:43,940
+risk for ovarian hyperstimulation syndrome رسك
+
+114
+00:08:43,940 --> 00:08:48,760
+الخطير أو خلّيني أقول إن المعضلة الخطيرة اللي ممكن
+
+115
+00:08:48,760 --> 00:08:54,180
+تظهر عند هؤلاء السيداتاللواتي يخضعنا إلى الـ
+
+116
+00:08:54,180 --> 00:08:59,400
+Control Ovarian Stimulation عفوا ممكن يصير عندهم
+
+117
+00:08:59,400 --> 00:09:03,940
+حالة سميتها قبل شوية Hyper Stimulation ولكن إن ظهر
+
+118
+00:09:03,940 --> 00:09:08,140
+عليهم symptoms بسميها في هذه الحالة Ovarian Hyper
+
+119
+00:09:08,140 --> 00:09:12,640
+Stimulation Syndrome وحنتكلم عنها باستفادة في الشق
+
+120
+00:09:12,640 --> 00:09:15,480
+التاني من المحاضرة الـ Ovarian Hyper Stimulation
+
+121
+00:09:15,480 --> 00:09:18,460
+Syndrome تتميز إن في عندي enlargement في الـ Ovary
+
+122
+00:09:18,460 --> 00:09:24,380
+زيادة في blood capillaryPermeability بالإضافة إلى
+
+123
+00:09:24,380 --> 00:09:29,100
+shifting للـ fluid داخل الـ space المحيط بالـ
+
+124
+00:09:29,100 --> 00:09:33,920
+abdominal المحيط بالـ ovary طبعاً، this result
+
+125
+00:09:33,920 --> 00:09:37,980
+يؤدى إلى تكوين ما يُعرف باسم hypovolemia بيؤدى إلى
+
+126
+00:09:37,980 --> 00:09:40,980
+تكوين hemoconcentration بيؤدى إلى تكوين
+
+127
+00:09:40,980 --> 00:09:43,480
+hypercoagulopathy
+
+128
+00:09:45,660 --> 00:09:49,940
+high bar coagulability هنتكلم عنها باستفادة كيف
+
+129
+00:09:49,940 --> 00:09:55,280
+ممكن يصير عندك high bar في ال coagulation ال OHSS
+
+130
+00:09:55,280 --> 00:10:01,260
+maybe have some complicated like acute renal
+
+131
+00:10:01,260 --> 00:10:09,380
+failure, hypovolemic shock, thrombosis
+
+132
+00:10:13,940 --> 00:10:19,840
+في عندي مشاكل في الجهاز التنفسي بالاضافة إلى أنه
+
+133
+00:10:19,840 --> 00:10:24,780
+قد يكون قاتل شو يعني قد يكون قاتل؟ اه قد يكون قاتل
+
+134
+00:10:24,780 --> 00:10:31,620
+ال OHSS اللي لم يعالج هيكون يؤدي بالوفاة للسيدات
+
+135
+00:10:31,620 --> 00:10:35,260
+مصابين فيه طبعا انا مش هستفيد في هذا الموضوع ولكن
+
+136
+00:10:35,260 --> 00:10:39,780
+كانت علاج بسيطهنعرف كيف بيكون قاتل بناء على ال
+
+137
+00:10:39,780 --> 00:10:44,560
+severity الخاصة فيه ال risk for OHSS can be high
+
+138
+00:10:44,560 --> 00:10:49,180
+as 6% in young women with the polycystic ovarian
+
+139
+00:10:49,180 --> 00:10:52,600
+syndrome طبعا ال polycystic ovarian syndrome حالة
+
+140
+00:10:52,600 --> 00:10:58,420
+مرضية تختلف عن ال OHSS ال polycystic ovarian
+
+141
+00:10:58,420 --> 00:11:03,100
+syndrome قد تؤدي إلى إعاقة الحمل بسبب وجود تكييسات
+
+142
+00:11:03,100 --> 00:11:08,310
+حول المبيض أو تكييساتفي المبيعات هذا مرض يختلف عن
+
+143
+00:11:08,310 --> 00:11:12,390
+المرض الآخر اسمه ovarian hyperstimulation syndrome
+
+144
+00:11:12,390 --> 00:11:15,830
+PCOS
+
+145
+00:11:15,830 --> 00:11:20,270
+ممكن يحدث بشكل طبيعي هذا بيحدث بفعل effect أو
+
+146
+00:11:20,270 --> 00:11:26,470
+influence factor زي ال exogenous hormone طيب كيف
+
+147
+00:11:26,470 --> 00:11:30,970
+يمكن تحضير الذأسية و إعطائها بعض الأنواع من
+
+148
+00:11:30,970 --> 00:11:34,150
+الأتوية التي يمكن أن تستخدم في تحفيز المبيعات؟
+
+149
+00:11:35,730 --> 00:11:40,570
+Controlled Ovarian Hyperstimulation كان فيما سبق
+
+150
+00:11:40,570 --> 00:11:48,190
+يتم فيه استخدام نوع معين من الدراج يسمى Colombirin
+
+151
+00:11:48,190 --> 00:11:53,250
+Citrate هذا النوع من أنواع الأدوية فيما بعد تم
+
+152
+00:11:53,250 --> 00:11:58,710
+استبداله بـHuman Monopiosal Gonadotropin وخدوا
+
+153
+00:11:58,710 --> 00:12:04,250
+بالكم من كلمة monopiosal و human يعني بشريويله
+
+154
+00:12:04,250 --> 00:12:08,750
+علاقة بسن اليأس عند السيدات ثم تم استبداله بالـ
+
+155
+00:12:08,750 --> 00:12:12,810
+Urinary FSH Preparation ثم تم استبداله بال
+
+156
+00:12:12,810 --> 00:12:17,130
+Recomponent FSH يعني لو أنا عرفت التدريج تبعته،
+
+157
+00:12:17,130 --> 00:12:21,330
+هيكون في البداية عندى من الأسفل إلى الأعلى بناء
+
+158
+00:12:21,330 --> 00:12:25,590
+على التقدم هيكون فيه End Human Monobiosal
+
+159
+00:12:25,590 --> 00:12:29,600
+Gonadotropin Urinary FSH Preparationو الـ
+
+160
+00:12:29,600 --> 00:12:33,700
+Recombinant FSH Preparation إذا ماهي
+
+161
+00:12:33,700 --> 00:12:37,420
+الجونادوتروبين؟ الجونادوتروبين هي الهرمونات المهمة
+
+162
+00:12:37,420 --> 00:12:41,340
+التي تفرز من الـ anterior lobopatary gland و تأثير
+
+163
+00:12:41,340 --> 00:12:46,300
+على الـ specific cell in the ovary هذه الهرمونات
+
+164
+00:12:46,300 --> 00:12:51,300
+أفضل مثال عليها الـ FSH أو هي عبارة عن الـ FSH و
+
+165
+00:12:51,300 --> 00:12:56,950
+LH الـ human monopiosal gonadotropinمتم استخدامه
+
+166
+00:12:56,950 --> 00:13:04,630
+في البداية عام 1960 وهو عبارة عن drug يستخدم من
+
+167
+00:13:04,630 --> 00:13:09,590
+أجل تحفيز المبيض The initial preparations were
+
+168
+00:13:09,590 --> 00:13:15,530
+very impure with mainly contaminated protein with
+
+169
+00:13:15,530 --> 00:13:22,030
+less than 5% of protein being bioactive بمعنى آخر
+
+170
+00:13:22,030 --> 00:13:26,460
+أن هذاالدراج اللي سميته human monobiosal
+
+171
+00:13:26,460 --> 00:13:31,100
+gonadotropin والذي استخدم في بدايات 1960 من أجل
+
+172
+00:13:31,100 --> 00:13:37,900
+تحفيز المبيان أول ما تم إنشائه كان باحتواء على
+
+173
+00:13:37,900 --> 00:13:42,060
+كمية كبيرة جدا من الشوائب فهو not pure drug
+
+174
+00:13:42,060 --> 00:13:45,740
+بالإضافة إلى أنه في بعض ال contaminant البروتين
+
+175
+00:13:45,740 --> 00:13:49,280
+اللي مفروض ما تكون موجودة فالمفروض لمن بدأ يعمل
+
+176
+00:13:49,280 --> 00:13:53,800
+stimulation للسيدة للovering خاص بسيدة معينةلازم
+
+177
+00:13:53,800 --> 00:13:58,820
+اعطيها pure drug يعني pure هرمون مافي other
+
+178
+00:13:58,820 --> 00:14:03,280
+compound ممكن تأثر سلبا على هذا ال structure
+
+179
+00:14:03,280 --> 00:14:12,000
+الموجود في جسد السيدة مع ذلك وبتتالي الاختبارات
+
+180
+00:14:12,000 --> 00:14:16,120
+على الهرمونات المستخلصة والمستخدمة والمصنعة في عام
+
+181
+00:14:16,120 --> 00:14:23,060
+1980 تم تحسين وتطوير نوع من أنواع ال drug عملنوع
+
+182
+00:14:23,060 --> 00:14:26,060
+من أنواع الـ Improvement للـ Action و الـ
+
+183
+00:14:26,060 --> 00:14:29,720
+Structure و الـ Composition الخاصة بالـ
+
+184
+00:14:29,720 --> 00:14:35,820
+Gonadotropin تحت مصطلح مهم جدا هو الـ Urinary FSH
+
+185
+00:14:35,820 --> 00:14:40,560
+و فكرته ببساطة أن في عند السيدات اللي بتصل لمرحلة
+
+186
+00:14:40,560 --> 00:14:47,120
+الـ Monopiose هيصير كمية releasing للـ FSH و LH في
+
+187
+00:14:47,120 --> 00:14:50,190
+الـ urine بكمية كبيرة جدافكانوا ياخدوا هذا ال
+
+188
+00:14:50,190 --> 00:14:54,330
+urine ويعملوله عملية extraction او عملية خلينا
+
+189
+00:14:54,330 --> 00:14:58,850
+نقول extraction لل FSH و extraction لل LH الموجودة
+
+190
+00:14:58,850 --> 00:15:01,830
+في كميات المهولة من ال urine الخاص بالسيدات اللي
+
+191
+00:15:01,830 --> 00:15:06,270
+وصلوا للمونوبيوز و بيعملوا بعد كده عملية تنقية إذا
+
+192
+00:15:06,270 --> 00:15:11,310
+سيدات بيجمعوا منهم ال urine بس سيدة وصلت إلى سن
+
+193
+00:15:11,310 --> 00:15:15,970
+المونوبيوز جمعوا ال urine حلجوا كمية كبيرة جدا من
+
+194
+00:15:15,970 --> 00:15:20,410
+ال FSH و LH يفرص في عينة ال urineعملوا extraction
+
+195
+00:15:20,410 --> 00:15:23,610
+للـ FSH والـ LH بعدين عملوا عملية ال purification
+
+196
+00:15:23,610 --> 00:15:28,030
+باستخدام ال monoclonal antibody أو ما يُعرف باسم
+
+197
+00:15:28,030 --> 00:15:32,810
+ال affinity chromatography ثم تطور هذا الأمر فأصبح
+
+198
+00:15:32,810 --> 00:15:37,230
+لدينا قدرة على استخدام ال DNA technology أو
+
+199
+00:15:37,230 --> 00:15:40,930
+biotechnology تحت مصطلح recombinant DNA وأكيد
+
+200
+00:15:40,930 --> 00:15:44,330
+عارفين إيش عن ال recombinant DNA ببساطة جدا ال
+
+201
+00:15:44,330 --> 00:15:48,650
+recombinant DNA هو أنا بجيب fragmentمن الـ DNA للـ
+
+202
+00:15:48,650 --> 00:15:53,010
+target protein أو target هرمون و بعمله عملية
+
+203
+00:15:53,010 --> 00:15:56,470
+ligation مع vector like بلزميد و البلزميد هذا
+
+204
+00:15:56,470 --> 00:15:59,450
+بعملها insertion داخل الـ E.coli for example و
+
+205
+00:15:59,450 --> 00:16:02,790
+بدفع ال E.coli إنها تتطور و تنمو و تتضاعف بكميات
+
+206
+00:16:02,790 --> 00:16:06,590
+كبيرة جدا مما يسمح لها بعمل replication و
+
+207
+00:16:06,590 --> 00:16:09,630
+transcription و translation للمادة اللي ورا فيها
+
+208
+00:16:09,630 --> 00:16:14,610
+plus ال inserted DNA فبالتالي ال protein هينتج
+
+209
+00:16:14,610 --> 00:16:19,160
+هعمله عملية collectionExtraction Purification
+
+210
+00:16:19,160 --> 00:16:26,360
+سميته Recomponent FSH وأول ما تم استخدام نوع معين
+
+211
+00:16:26,360 --> 00:16:31,540
+من أنواع الـ Ovary سموها Chinese Hemisphere Ovary
+
+212
+00:16:31,540 --> 00:16:37,860
+Cell Line CHO Chinese Hemisphere Ovary Cell Line
+
+213
+00:16:37,860 --> 00:16:43,300
+وذلك لأنها تنتج كمية كبيرة جدا من البروتينالروتين
+
+214
+00:16:43,300 --> 00:16:47,540
+الموجود في جسم الإنسان post modification حتى بعد
+
+215
+00:16:47,540 --> 00:16:50,920
+ال post modification لأن احنا عارفين ان معظم
+
+216
+00:16:50,920 --> 00:16:54,420
+الهرمونات Alpha subunit و Beta subunit ال Alpha
+
+217
+00:16:54,420 --> 00:16:58,220
+subunit متشابهة في الجميع لل Beta subunit مختلفة
+
+218
+00:16:58,220 --> 00:17:03,020
+فوجدوا ان ال chinese hamster ovarian cell line
+
+219
+00:17:03,020 --> 00:17:06,680
+تستطيه ان تنتج Beta subunit من ال gonadotropin
+
+220
+00:17:06,680 --> 00:17:11,260
+هرميون يشبه بشكل كبير جدا جدا جدا ل human
+
+221
+00:17:11,260 --> 00:17:16,480
+gonadotropinفبالتالي أستطيع أن أجبرها و أسخرها لكي
+
+222
+00:17:16,480 --> 00:17:21,660
+تنتج هذا الهرمون المطلوب control أو مايعرف اسم ال
+
+223
+00:17:21,660 --> 00:17:25,640
+hamster أو ال chinese hamster cell line were
+
+224
+00:17:25,640 --> 00:17:29,860
+selected as recipient cell since they were easily
+
+225
+00:17:29,860 --> 00:17:33,420
+transfer with a foreign DNA and are capable to
+
+226
+00:17:33,420 --> 00:17:36,500
+synthesize a very large amount of complex
+
+227
+00:17:36,500 --> 00:17:40,840
+glycoprotein هي في عندي كمان صفتين جديدتين رغم
+
+228
+00:17:40,840 --> 00:17:44,590
+أنها بتفرز ما يشبهما يوجد في جسم الإنسان they
+
+229
+00:17:44,590 --> 00:17:47,250
+could be growing in the cell culture on a large
+
+230
+00:17:47,250 --> 00:17:50,790
+scale ممكن أنميها بكميات كبيرة جدا وكميات مهولة
+
+231
+00:17:50,790 --> 00:17:56,070
+اللي تخدمني على الصعيد ال industrial لو أنا فرجت
+
+232
+00:17:56,070 --> 00:18:01,210
+فرقت ببساطة جدا ما بين ال urinary FSH و ال human
+
+233
+00:18:01,210 --> 00:18:06,190
+monobiosis gonadotropin ال human monobiosis
+
+234
+00:18:06,190 --> 00:18:11,350
+gonadotropin يُرمز له H humanM-monobiosal G
+
+235
+00:18:11,350 --> 00:18:15,950
+-gonadotropin بيقول ببساطة إن نسبة ال FSH إلى ال
+
+236
+00:18:15,950 --> 00:18:21,410
+LH في ال HMG 1 إلى 1 بينما في ال urinary FSH
+
+237
+00:18:21,410 --> 00:18:26,190
+preparation كمية contained a small amount of LH
+
+238
+00:18:26,190 --> 00:18:30,910
+يعني كمية ال LH إلى كمية ال FSH متساوية في ال
+
+239
+00:18:30,910 --> 00:18:34,610
+human monobiosal gonadotropin ولكن كمية ال ALH
+
+240
+00:18:34,610 --> 00:18:39,300
+قليلة في ال urinary FSH من اسمهUranary FSH يعني
+
+241
+00:18:39,300 --> 00:18:44,820
+كمية الـ FSH عارية جدا طبعا الـ Follicles may be
+
+242
+00:18:44,820 --> 00:18:49,140
+exposed to the high level of LH وجدوا أن تعرض الـ
+
+243
+00:18:49,140 --> 00:18:53,180
+Ovary لكميات كبيرة جدا من الـ LH خلال عملية ال
+
+244
+00:18:53,180 --> 00:18:57,640
+development و قبل عملية ال ovulation يلعب دورة
+
+245
+00:18:57,640 --> 00:19:02,080
+سلبية على عملية ال ovulation بشكلها الأساسي مش
+
+246
+00:19:02,080 --> 00:19:07,550
+منطقي أعرض ال Ovary و ال Follicleلدوز عالم من
+
+247
+00:19:07,550 --> 00:19:13,010
+الالأتش جاب اليوم 13 و14 لأن إذا بتذكروا حكينا إن
+
+248
+00:19:13,010 --> 00:19:16,790
+الالأتش بيلعب دور مهم جدا في ال ovulation فالمفروض
+
+249
+00:19:16,790 --> 00:19:20,610
+بناء على ال chart ما يظهر إلا على هيئة sharp في
+
+250
+00:19:20,610 --> 00:19:26,150
+اليوم 13 و14 ظهوره قبل هذه الأيام يعني في أيام ال
+
+251
+00:19:26,150 --> 00:19:31,320
+development له تأثير سلبي فبالتالي المفروضما يكون
+
+252
+00:19:31,320 --> 00:19:36,040
+موجود فمنطقيا ان تأثير ال human monobiosal
+
+253
+00:19:36,040 --> 00:19:40,260
+gonadotropin إذا قرنته بال urinary FSH preparation
+
+254
+00:19:40,260 --> 00:19:45,500
+على ال development هيكون سيء إلى حد ما سيء إلى حد
+
+255
+00:19:45,500 --> 00:19:50,000
+ما فبالتالي high level of LH during their early
+
+256
+00:19:50,000 --> 00:19:52,520
+stage of development when stimulated with human
+
+257
+00:19:52,520 --> 00:19:55,920
+monobiosal gonadotropin to compare to the urinary
+
+258
+00:19:55,920 --> 00:20:00,880
+FSHهذا بيعمل عملية failure للـ follicle maturation
+
+259
+00:20:00,880 --> 00:20:05,160
+إلى حد ما من ال study have demonstrated that too
+
+260
+00:20:05,160 --> 00:20:08,420
+much allergy during this time هي follicular
+
+261
+00:20:08,420 --> 00:20:15,160
+development before ovulation day هيلعب دورة سلبية
+
+262
+00:20:15,160 --> 00:20:19,540
+ودورة سلبية في عملية ال maturation ولاجوا انه
+
+263
+00:20:19,540 --> 00:20:25,680
+associated with more one rules او more one point
+
+264
+00:20:25,680 --> 00:20:28,910
+for example the first oneبعمل reduction في ال rate
+
+265
+00:20:28,910 --> 00:20:31,730
+of fertilization بعمل reduction في ال pregnancy
+
+266
+00:20:31,730 --> 00:20:35,210
+rate و بعمل increase في ال spontaneous abortion
+
+267
+00:20:35,210 --> 00:20:39,050
+يعني السيدة إذا اتعرضت لل human
+
+268
+00:20:39,050 --> 00:20:43,570
+monopiosargonadotropin يعني ال ovary اتعرضت لدوز
+
+269
+00:20:43,570 --> 00:20:47,970
+عالي جدا من ال LH قبل أيام التطوير في الأشهر أيام
+
+270
+00:20:47,970 --> 00:20:52,410
+الأولى هذا وجدوا أنه بلعب دور سلبي و بأثر بشكل
+
+271
+00:20:52,410 --> 00:20:56,240
+سلبي على عملية ال oocyte maturationوالـ Follicular
+
+272
+00:20:56,240 --> 00:20:59,660
+Maturation أو Development، هذه نقطة وجدوا إنه
+
+273
+00:20:59,660 --> 00:21:02,820
+بيأثر سلبًا على ال rate of fertilization و rate of
+
+274
+00:21:02,820 --> 00:21:06,100
+pregnancy زيادة الألاتش في هذا المرحلة بيعمل
+
+275
+00:21:06,100 --> 00:21:10,920
+reduction فالعلاقة علاقة عكسية أيضًا وجدوا إنه
+
+276
+00:21:10,920 --> 00:21:15,680
+بيعمل زيادة في احتمالية حدوث ال abortion بسبب أو
+
+277
+00:21:15,680 --> 00:21:20,220
+من نوع spontaneous abortion هذا قران اتبان لل
+
+278
+00:21:20,220 --> 00:21:25,310
+human مونوبيوزر جونات أتروبيوالـ Urinary FSH طب لو
+
+279
+00:21:25,310 --> 00:21:28,390
+أنا قرنت بين الـ Recombinant FSH و الـ Human
+
+280
+00:21:28,390 --> 00:21:32,510
+Monobiosal Gonadotropin The main source of Human
+
+281
+00:21:32,510 --> 00:21:36,810
+Monobiosal Gonadotropin and FSH preparation هي الـ
+
+282
+00:21:36,810 --> 00:21:40,870
+urine زي ما حكينا بشكل أساسي أن المصدر الأساسي للـ
+
+283
+00:21:40,870 --> 00:21:44,530
+FSH في الـ Human Monobiosal Gonadotropin هو عبارة
+
+284
+00:21:44,530 --> 00:21:47,890
+عن الـ FSH استخلص من الـ urine sample الخاص
+
+285
+00:21:47,890 --> 00:21:52,500
+بالسيدات التي وصلت إلى أو اللواتي وصلنا إلىالـ
+
+286
+00:21:52,500 --> 00:21:55,780
+monobiosis الـ development الجديدة أو التكنيك
+
+287
+00:21:55,780 --> 00:21:58,280
+الجديد أو التكنولوجيا الجديدة اللي سميناها
+
+288
+00:21:58,280 --> 00:22:02,820
+recombinant يعني إيه؟ لأ ما إلها علاقة ما إلها
+
+289
+00:22:02,820 --> 00:22:06,880
+علاقة بال in vitro .. in vivo لأ أنا بصنا ال FSH
+
+290
+00:22:06,880 --> 00:22:13,020
+in vitro يشبه بشكل كبير قد تصل ل 99% و بعض الأحيان
+
+291
+00:22:13,020 --> 00:22:17,880
+إلى 100% إلى ال human FSH this preparation have an
+
+292
+00:22:17,880 --> 00:22:22,260
+extremely high purity which make them attractiveas
+
+293
+00:22:22,260 --> 00:22:27,480
+alternative to human monobiosargonadotropin and
+
+294
+00:22:27,480 --> 00:22:33,060
+urinary FSH وذلك لأن سلبياته و ال complications
+
+295
+00:22:33,060 --> 00:22:37,960
+خاصة فيه تعتبر قليلة جدا مقارنة بال complications
+
+296
+00:22:37,960 --> 00:22:42,600
+التي تنتج عن ال human monobiosargonadotropin or
+
+297
+00:22:42,600 --> 00:22:50,320
+urinary FSH دراساتوجريت في عام 2003 وجدت أنه مافي
+
+298
+00:22:50,320 --> 00:22:52,900
+significant مافي difference significant ما بين
+
+299
+00:22:52,900 --> 00:22:58,520
+استخدام ال HMG واستخدام ال recombinant FSH من حيث
+
+300
+00:22:58,520 --> 00:23:03,980
+نمو وفطور ال void من حيث معدل الحمل ومن حيث ال
+
+301
+00:23:03,980 --> 00:23:09,740
+life pairsكلام يحترم هذا في 2003 طب لو اتقدم الزمن
+
+302
+00:23:09,740 --> 00:23:18,800
+وجدوا في 2008 فيه دراسات وجدت انه في اختلاف في
+
+303
+00:23:18,800 --> 00:23:24,660
+ال life birth rate ما بين استخدام ال HMG و ال
+
+304
+00:23:24,660 --> 00:23:29,440
+recombinant FSH فوجدوا ان السيدات او الحالات اللي
+
+305
+00:23:29,440 --> 00:23:33,920
+اخدت recombinant FSH معدل الحمل عندهم اعلىمن
+
+306
+00:23:33,920 --> 00:23:37,180
+السيدات اللي أخدوا human monobiosis الجنادو تروبيه
+
+307
+00:23:37,180 --> 00:23:41,660
+و هذا المنطق جدا بسبب الأسباب اللي ذكرناها في مصدر
+
+308
+00:23:41,660 --> 00:23:48,300
+في أول شغلة مصطلح سموه جنادو تروبيين releasing
+
+309
+00:23:48,300 --> 00:23:53,340
+hormone agonist NGRARHA
+
+310
+00:23:53,340 --> 00:23:58,100
+جنادو تروبيين releasing hormone agonist وهو عبارة
+
+311
+00:23:58,100 --> 00:24:02,260
+عن نوع من أنواع ال protocols التي تستخدممن أجل عمل
+
+312
+00:24:02,260 --> 00:24:05,540
+down regulation for pituitary gland شو يعني down
+
+313
+00:24:05,540 --> 00:24:08,700
+regulation أنه بتقول للـ pituitary gland بيكفيكي
+
+314
+00:24:08,700 --> 00:24:14,780
+إفراز FSH و LH أنا هقوم بالوظيفة من حيث إعطاء
+
+315
+00:24:14,780 --> 00:24:19,780
+هرمونات خارجية وبالتالي أوقف إفراز الهرمونات
+
+316
+00:24:19,780 --> 00:24:25,180
+الطبيعية وأعطي هرمونات مصنعة من الخارج أتحكم في
+
+317
+00:24:25,180 --> 00:24:26,620
+كميتها كطبيب
+
+318
+00:24:30,380 --> 00:24:33,720
+طيب بالنسبة للـ gonadotropin releasing hormone
+
+319
+00:24:33,720 --> 00:24:37,980
+agonist قسموها إلى عدة أقسام بناء على ال duration
+
+320
+00:24:37,980 --> 00:24:42,380
+قسموها إلى long protocol يعني بتاخد عدد أيام أكتر
+
+321
+00:24:42,380 --> 00:24:47,000
+short protocol و ultra short protocol يعني في عندي
+
+322
+00:24:47,000 --> 00:24:50,480
+ultra short protocol و في عندي short protocol و في
+
+323
+00:24:50,480 --> 00:24:53,440
+عندي longer protocol حنا عارف جديش عدد أيام كل
+
+324
+00:24:53,440 --> 00:24:57,260
+protocolThe stimulation may be initiated in the
+
+325
+00:24:57,260 --> 00:25:00,520
+first day of that cycle إذا والله أنا بدأت ال
+
+326
+00:25:00,520 --> 00:25:03,060
+stimulation من أول يوم في الدورة من أول يوم
+
+327
+00:25:03,060 --> 00:25:07,120
+bleeding بسمي هذا ال protocol short protocol the
+
+328
+00:25:07,120 --> 00:25:12,920
+cycle preceding the stimulation cycle long
+
+329
+00:25:12,920 --> 00:25:17,520
+protocol بمعنى أخر بمعنى أخر أنه أنا عملت
+
+330
+00:25:17,520 --> 00:25:21,320
+stimulation في ال cycle السابقة هذا ال cycle
+
+331
+00:25:21,320 --> 00:25:25,070
+السابق يعني أنا أخدتتلت أربع خمس أيام من أيام
+
+332
+00:25:25,070 --> 00:25:28,970
+الدورة السابقة فمعناه هاخد سبع أيام من الدورة
+
+333
+00:25:28,970 --> 00:25:31,970
+السابقة و سبع أيام من الدورة الجديدة حتى أصل إلى
+
+334
+00:25:31,970 --> 00:25:34,830
+يوم الطبويد يعني أخدت أربعة عشر أيام بسميه long
+
+335
+00:25:34,830 --> 00:25:38,790
+protocol هاي الفرق بين ال long و ال short ال short
+
+336
+00:25:38,790 --> 00:25:42,950
+protocol بدأت من أول يوم الدورة عمل stimulation ال
+
+337
+00:25:42,950 --> 00:25:46,170
+long protocol بدأت من الأيام السابقة أخدت أيام
+
+338
+00:25:46,170 --> 00:25:49,830
+سابقة من الدورة السابقة أو أيام إضافية من الدورة
+
+339
+00:25:49,830 --> 00:25:55,540
+السابقة يعني كإني بدأت مثلا مثلافي اليوم رقم 20 من
+
+340
+00:25:55,540 --> 00:26:01,020
+الدورة السابقة و أخدت أخر 8 أيام و أخدت كمان 10
+
+341
+00:26:01,020 --> 00:26:03,720
+أيام من الدورة الجديدة و أخدت كأني ما أخدت 18 أيام
+
+342
+00:26:03,720 --> 00:26:06,980
+و بيسعلها طبعا هذه الأيام ال duration تعتمد على
+
+343
+00:26:06,980 --> 00:26:12,180
+عمر السيدة طبيعة المبيض مستوى هرموني القامعش
+
+344
+00:26:12,180 --> 00:26:17,720
+سنتحدث عن هذا مستقبلا ان شاء اللهseveral years
+
+345
+00:26:17,720 --> 00:26:23,200
+later following a several studies have been shown
+
+346
+00:26:23,200 --> 00:26:27,660
+that a long protocol gave the best result in the
+
+347
+00:26:27,660 --> 00:26:30,540
+term of pregnancy rate يعني بناء على الدراسات
+
+348
+00:26:30,540 --> 00:26:34,720
+الجديدة اللتي يتم استحداثها مقارنة ما بين ال
+
+349
+00:26:34,720 --> 00:26:38,820
+different protocol وجدوا ان معدل ال pregnancy rate
+
+350
+00:26:38,820 --> 00:26:43,600
+بيكون أفضل إذا استخدمنا ال long protocol بمنطق جيد
+
+351
+00:26:44,030 --> 00:26:46,770
+في الـ long protocol أنا ما بخضع و ما بجبر
+
+352
+00:26:46,770 --> 00:26:50,990
+البويضات أن تتطور بسرعة و ما بعطيها دوز عالي لأ
+
+353
+00:26:50,990 --> 00:26:54,810
+أنا بعطي دوز معقول خلال فترة زمنية طويلة يعني كإني
+
+354
+00:26:54,810 --> 00:26:58,790
+بخل المبيض يشتغل بوضعه الطبيعي ولكن تحت تأثير
+
+355
+00:26:58,790 --> 00:27:02,030
+الهرمونات اللي أنا بعطيها مش الهرمونات الطبيعية
+
+356
+00:27:02,030 --> 00:27:06,290
+عشان كده ممكن يكون عندي ال pregnancy rate أفضل عند
+
+357
+00:27:06,290 --> 00:27:12,090
+استخدام ال long protocolفي مادة بيسموها
+
+358
+00:27:12,090 --> 00:27:16,170
+gonadotropin-releasing hormone analogues شو يعني
+
+359
+00:27:16,170 --> 00:27:20,210
+analogues؟ ال analogues ببساطة هي عبارة عن نوع من
+
+360
+00:27:20,210 --> 00:27:24,890
+أنواع المواد المصنعة مشبه مادة طبيعية أصلية موجودة
+
+361
+00:27:24,890 --> 00:27:28,670
+في جسم الإنسان فسموها gonadotropin-releasing
+
+362
+00:27:28,670 --> 00:27:32,190
+hormone analogues هي عبارة عن short peptide من
+
+363
+00:27:32,190 --> 00:27:35,750
+gonadotropin-releasing hormone يعني هي عبارة عن
+
+364
+00:27:35,750 --> 00:27:39,290
+هرمون اسمه gonadotropin-releasing hormone ولكن
+
+365
+00:27:39,290 --> 00:27:44,860
+short peptidethat caused profound inhibition of
+
+366
+00:27:44,860 --> 00:27:48,400
+estrogen and androgen synthase وجدوا أن
+
+367
+00:27:48,400 --> 00:27:52,360
+الـAnalogues هذه، اللي هي عبارة عن short peptide
+
+368
+00:27:52,360 --> 00:27:55,600
+من الـGonadotropin releasing hormone تلعب دورة
+
+369
+00:27:55,600 --> 00:28:00,340
+مهمة جدا في تثبيت الاستروجين والتثبيت الاندروجين
+
+370
+00:28:01,980 --> 00:28:05,220
+Gynadotropin-releasing hormone analogues were
+
+371
+00:28:05,220 --> 00:28:09,280
+created by a series of modification in
+
+372
+00:28:09,280 --> 00:28:12,260
+Gynadotropin-releasing hormone molecule that led
+
+373
+00:28:12,260 --> 00:28:16,960
+to a viable of a new agonist or antagonist يعني
+
+374
+00:28:16,960 --> 00:28:19,740
+أنا جبت الـGynadotropin-releasing hormone عملت
+
+375
+00:28:19,740 --> 00:28:23,220
+عليه modification، كوللي مادة جديدة اسمها
+
+376
+00:28:23,220 --> 00:28:26,660
+Gynadotropin-releasing hormone analogues وجود هذه
+
+377
+00:28:26,660 --> 00:28:30,400
+المادة الجديدة أدت إلى وجود two protocol عظيمين
+
+378
+00:28:30,620 --> 00:28:33,440
+البروتوكول الأول اسمه agonist البروتوكول التاني
+
+379
+00:28:33,440 --> 00:28:41,240
+اسمه antagonist agonist يعني محافظة مناهض يعني
+
+380
+00:28:41,240 --> 00:28:47,280
+بيعمل ضد بمعنى أخر ال agonist بيعمل ببساطة جدا
+
+381
+00:28:47,280 --> 00:28:52,600
+enhancing for gonadotropin production كأنه بيجبر
+
+382
+00:28:52,600 --> 00:28:56,650
+ال anterior lobe أو بطيوتة رجلانعلى إنتاج كمية
+
+383
+00:28:56,650 --> 00:29:01,390
+كبيرة جدا من الـ gonadotropin بين جثين FSH وH ما
+
+384
+00:29:01,390 --> 00:29:08,370
+إستمرار إعطاء هذا الهرمون الخارجي كدا الخلية أو
+
+385
+00:29:08,370 --> 00:29:11,790
+الغدة بتقول و الله طالما فيه هرمون يأتي من الخارج
+
+386
+00:29:11,790 --> 00:29:17,150
+أنا مافي داعي أفرز فتتوقف الغدة عن الإفراز فيبقى
+
+387
+00:29:17,150 --> 00:29:21,170
+الجسم فقط يستجيب إلى كمية الـ gonadotropin التي
+
+388
+00:29:21,170 --> 00:29:25,770
+تأتي من الخارج والتي تتمثلفي الـLH والـFSH يعني
+
+389
+00:29:25,770 --> 00:29:28,970
+فكرته أنه في البداية بيحفظ الـAnterior Lobe
+
+390
+00:29:28,970 --> 00:29:32,590
+وPatentary Glan لإفراز الـGonadotropin بعد فترة مع
+
+391
+00:29:32,590 --> 00:29:35,350
+استمرار ال injection هتيجي في الـAnterior Lobe
+
+392
+00:29:35,350 --> 00:29:38,290
+وPatentary Glan ليش تجيد نفسها طالما فيه هرمون
+
+393
+00:29:38,290 --> 00:29:42,410
+جايس بييجي بيصير reduction في ال level of FSH LH
+
+394
+00:29:42,410 --> 00:29:46,210
+المفروض من الـAnterior Lobe وPatentary Glan ويتم
+
+395
+00:29:46,210 --> 00:29:50,590
+استعادة استعادة عنهم من الـGonadotropin releasing
+
+396
+00:29:50,590 --> 00:29:55,920
+hormone الذي يأتي من الخارجأول وهذا المصطلح اللي
+
+397
+00:29:55,920 --> 00:30:02,160
+سموه Gunadotropin agonist agonist يعني يحفظ ثم
+
+398
+00:30:02,160 --> 00:30:06,720
+يثبت وهي اللي شفناها حفظ الانتريو اللوب و بطيت
+
+399
+00:30:06,720 --> 00:30:11,740
+رجلها وبعدين ثبتها traditionally a tutoring down
+
+400
+00:30:11,740 --> 00:30:15,060
+regulation has been the most common protocol
+
+401
+00:30:15,060 --> 00:30:19,560
+utilized by IGC or IVF يعني كل ال protocolات اللي
+
+402
+00:30:19,560 --> 00:30:23,180
+لها علاقة بال stimulation وظيفتها الأساسية أنها
+
+403
+00:30:23,180 --> 00:30:28,170
+تقومبإيقاف الـ anterior loop وبتيوتر الجلد من
+
+404
+00:30:28,170 --> 00:30:31,750
+إفراز الـ FSH والـ H يعني كذا بتعمل ال blocking خد
+
+405
+00:30:31,750 --> 00:30:38,270
+بالكوا ال blocking مؤقت طبعا من خلال إعطاء هرمون
+
+406
+00:30:38,270 --> 00:30:41,910
+مصنع في الخارج نعطيه subcutaneous ال
+
+407
+00:30:41,910 --> 00:30:44,650
+administration of gonadotropin releasing hormone
+
+408
+00:30:44,650 --> 00:30:48,010
+agonist will be initiated the cause of releasing
+
+409
+00:30:48,010 --> 00:30:51,430
+FSH الـ H from the anterior loop هذا الكلام حكيناه
+
+410
+00:30:51,430 --> 00:30:57,060
+في ال slideالفقرة الأخيرة بعد أكثر من يوم بعد
+
+411
+00:30:57,060 --> 00:31:01,200
+several days الإعطاء المستمر بيعمل inhibition و
+
+412
+00:31:01,200 --> 00:31:04,060
+dropping في مستوى الافاساتش والقلاتش المفروض من
+
+413
+00:31:04,060 --> 00:31:06,780
+هذه ال loop أو من هذه ال gland دي اسمه anterior
+
+414
+00:31:06,780 --> 00:31:10,460
+and pituitary gland نسبة إلى وجود كمية كبيرة جدا
+
+415
+00:31:10,460 --> 00:31:14,240
+في الدم فمفيش داعة تفرز طالما في كمية كافية في
+
+416
+00:31:14,240 --> 00:31:18,520
+الدم عالية في الدم أنا ك loop اسمي anterior loop و
+
+417
+00:31:18,520 --> 00:31:22,730
+pituitary gland ما بفرز ال hormone طالما موجودةSo
+
+418
+00:31:22,730 --> 00:31:26,890
+dropping in the circulating concentration of FSH
+
+419
+00:31:26,890 --> 00:31:33,010
+and LH and to prevent LH wave or surge من خلال
+
+420
+00:31:33,010 --> 00:31:37,770
+مصطلح بيسمي desensitization أي receptor
+
+421
+00:31:37,770 --> 00:31:41,960
+desensitization يعني الفكرة ببساطةإنه أنا كطبيب
+
+422
+00:31:41,960 --> 00:31:45,340
+باعطي الـ gonadotropin-releasing hormone agonist
+
+423
+00:31:45,340 --> 00:31:51,480
+عدة أيام بحفظ الخلية أو الغدة الاسمها anterior
+
+424
+00:31:51,480 --> 00:31:55,540
+lobe وبتوتر جلاد لإفراز ال FSH والالاتش باستمرار
+
+425
+00:31:55,540 --> 00:32:00,120
+ال injection الغدة بتقول المستوى عالي أنا ما بد
+
+426
+00:32:00,120 --> 00:32:04,120
+أفرز فتتوقف على إفراز ال normal FSH والالاتش ال
+
+427
+00:32:04,120 --> 00:32:08,870
+human ال inside ال indigenousمع استمرار الإعطاء
+
+428
+00:32:08,870 --> 00:32:11,350
+بيصير ال dropping في ال level للأفقس أتش والقلقش
+
+429
+00:32:11,350 --> 00:32:14,770
+ال dropping في ال level للأفقس أتش والقلقش يؤدي
+
+430
+00:32:14,770 --> 00:32:20,290
+إلى منع تكوين القلقش search or قلقش with تحت مصطلح
+
+431
+00:32:20,290 --> 00:32:25,510
+بنسمي desensitization or receptor desensitization
+
+432
+00:32:25,510 --> 00:32:29,110
+so what's the meaning of desensitization what's
+
+433
+00:32:29,110 --> 00:32:31,170
+the meaning of receptor desensitization
+
+434
+00:32:31,810 --> 00:32:35,450
+desensitization of this phenomenon occurs when
+
+435
+00:32:35,450 --> 00:32:39,450
+receptor decreases its response to agonist at high
+
+436
+00:32:39,450 --> 00:32:44,190
+concentration يعني أنا ك response موجود على سطح ال
+
+437
+00:32:44,190 --> 00:32:48,070
+ovary أو خلايا معينة في ال ovary باستقبل ال FSH
+
+438
+00:32:48,070 --> 00:32:53,750
+هيصير استقبالي لل FSH و رضي على ال FSH من خلال ال
+
+439
+00:32:53,750 --> 00:33:00,030
+response قليل جدا هذه بنسميها desensitization it's
+
+440
+00:33:00,030 --> 00:33:06,250
+a process through whichوهذا يحدث من خلال إعطاء جرع
+
+441
+00:33:06,250 --> 00:33:09,750
+متتالية من الـ human gonadotropin-releasing
+
+442
+00:33:09,750 --> 00:33:13,710
+hormone agonist خلال عملية induction الحدث
+
+443
+00:33:13,710 --> 00:33:17,010
+Inducing Stimulation Stimulation بنسميها induction
+
+444
+00:33:17,010 --> 00:33:22,730
+كمان هذا المصطلح بسميه desensitization يعني
+
+445
+00:33:22,730 --> 00:33:28,650
+reduction in the response of receptor receptor for
+
+446
+00:33:28,650 --> 00:33:31,970
+example gonadotropin-releasing hormone agonist are
+
+447
+00:33:31,970 --> 00:33:37,400
+typeof medication that suppress ovulation by
+
+448
+00:33:37,400 --> 00:33:39,560
+stopping the production of estrogen and
+
+449
+00:33:39,560 --> 00:33:42,620
+progesterone الـ gonadotropin releasing hormone
+
+450
+00:33:42,620 --> 00:33:47,660
+agonist they had ال advantage تبعته انه عنده high
+
+451
+00:33:47,660 --> 00:33:51,560
+affinity for gonadotropin releasing hormone
+
+452
+00:33:51,560 --> 00:33:56,140
+receptor compared to native يعني انا لو قرنت ال
+
+453
+00:33:56,140 --> 00:34:02,710
+receptor لو قرنت ال receptor قابليتها للارتباطما
+
+454
+00:34:02,710 --> 00:34:05,010
+الـ agonist جناد تربين releasing hormone و لا
+
+455
+00:34:05,010 --> 00:34:08,150
+الناتيف هتلاقي اللي جناد تربين releasing hormone
+
+456
+00:34:08,150 --> 00:34:12,030
+إله قابلية للارتباط مع الـ receptor أكتر من
+
+457
+00:34:12,030 --> 00:34:15,490
+الناتيف عشان كده إله أفضلية they have greater
+
+458
+00:34:15,490 --> 00:34:19,290
+resistance to enzyme breakdown فطالما بقاوم
+
+459
+00:34:19,290 --> 00:34:22,850
+التكسير بفعل الإنزيمات المحللة إذاً هيبقى لفترة
+
+460
+00:34:22,850 --> 00:34:27,450
+زمنية طويلة جدا إذا فترة بقاءه أكتر من فترة بقاء
+
+461
+00:34:27,450 --> 00:34:30,450
+الناتيف جناد تربين releasing hormonethey have a
+
+462
+00:34:30,450 --> 00:34:34,930
+prolonged life half-life شو يعني طالما فترة بقاءه
+
+463
+00:34:34,930 --> 00:34:39,690
+أطول و طالما بيقاوم إذا فترة بقاءه أطول يعني ال
+
+464
+00:34:39,690 --> 00:34:42,630
+half-life تبعته أطول من النتيجة هذه تعتبر
+
+465
+00:34:42,630 --> 00:34:46,970
+advantage خاصة بال gonadotropin releasing hormone
+
+466
+00:34:46,970 --> 00:34:52,090
+بشكل عام ال gonadotropin releasing hormone agonist
+
+467
+00:34:52,090 --> 00:34:59,220
+يجب أن تُعطى يجب أن تُعطى لمدة 10 إلى 15 يومbefore
+
+468
+00:34:59,220 --> 00:35:02,100
+down regulation يعني قبل ما يصير ال down
+
+469
+00:35:02,100 --> 00:35:06,240
+regulation السيدة بتكون ماخدة dose من الجناد
+
+470
+00:35:06,240 --> 00:35:09,040
+التروبيين releasing hormone agonist من 10 ل 15
+
+471
+00:35:09,040 --> 00:35:16,720
+اشهر يوم علشان يصير في عيندي سرعة في استجابة ال
+
+472
+00:35:16,720 --> 00:35:20,400
+anterior loop لبطيوتر الجلد من أجل إخفاض مستوى ال
+
+473
+00:35:20,400 --> 00:35:25,140
+FSH والLH يعني سرعة في ال dropping الخاصة بال FSH
+
+474
+00:35:25,140 --> 00:35:29,510
+والLH نتيجةأو الخاصة بعمل ما يُعرف اسم
+
+475
+00:35:29,510 --> 00:35:33,110
+Downregulation of antilipopapotatory gland لازم
+
+476
+00:35:33,110 --> 00:35:36,430
+أبدأ عملية ال injection بالجناداتروبيين releasing
+
+477
+00:35:36,430 --> 00:35:40,390
+hormone في مرحلة ال middle utl phase أي ما يُعرف
+
+478
+00:35:40,390 --> 00:35:45,810
+في اليوم ال 21 من الدورة السابقة إذا أنا في عندي
+
+479
+00:35:45,810 --> 00:35:50,890
+احتمالين و التالت جاي في الطريقة الاحتمال الأول إن
+
+480
+00:35:50,890 --> 00:35:55,570
+السيدة لازم يصيرها injection و inductionبالـ
+
+481
+00:35:55,570 --> 00:35:58,830
+gonadotropin-releasing hormone agonist لمدة من 10
+
+482
+00:35:58,830 --> 00:36:02,510
+إلى 15 يوم جابل الـ down regulation علشان يصير
+
+483
+00:36:02,510 --> 00:36:06,950
+عندي down regulation سريع ببدأ في اليوم 21 من
+
+484
+00:36:06,950 --> 00:36:11,510
+الدورة السابقة ببدأ في اليوم 21 من الدورة السابقة
+
+485
+00:36:11,510 --> 00:36:15,650
+it can also be started in the early follicular
+
+486
+00:36:15,650 --> 00:36:21,600
+phase في اليوم السادس أو اليوم التلاتعاش أيضابعد
+
+487
+00:36:21,600 --> 00:36:26,340
+انتجار
+
+488
+00:36:26,340 --> 00:36:33,840
+الانترول للبطيوتر الانتجار
+
+489
+00:36:33,840 --> 00:36:34,320
+الانتجار الانتجار الانتجار الانتجار الانتجار
+
+490
+00:36:34,320 --> 00:36:36,960
+الانتجار الانتجار الانتجار الانتجار الانتجار
+
+491
+00:36:36,960 --> 00:36:37,020
+الانتجار الانتجار الانتجار الانتجار الانتجار
+
+492
+00:36:37,020 --> 00:36:37,240
+الانتجار الانتجار الانتجار الانتجار الانتجار
+
+493
+00:36:37,240 --> 00:36:37,240
+الانتجار الانتجار الانتجار الانتجار الانتجار
+
+494
+00:36:37,240 --> 00:36:37,240
+الانتجار الانتجار الانتجار الانتجار الانتجار
+
+495
+00:36:37,240 --> 00:36:41,560
+الانتجار الانتجار الانتجار الانتجار الانتجار
+
+496
+00:36:41,560 --> 00:36:50,400
+الانتجار الانتجار الانتجار الانتجار الانتجار الالـ
+
+497
+00:36:50,400 --> 00:36:54,820
+gonadotropin releasing hormone agonist كمية الإبرة
+
+498
+00:36:54,820 --> 00:36:59,100
+اللي باعطيها حتى الوصول إلى مرحلة ال ovulation
+
+499
+00:36:59,100 --> 00:37:06,720
+باعطي FSH علشان يعمل نضوج للبويضة استعدادا للإبادة
+
+500
+00:37:06,720 --> 00:37:11,640
+استعدادا لل ovulation طبعا ال dose of FSH required
+
+501
+00:37:11,640 --> 00:37:14,820
+may be different from one person to another person
+
+502
+00:37:14,820 --> 00:37:19,320
+يعني من 150 إلى 450 international unit per day
+
+503
+00:37:19,720 --> 00:37:24,500
+فبالتالي ال FSH هو المسئول عن عملية .. المسئول عن
+
+504
+00:37:24,500 --> 00:37:29,680
+عملية ال maturation of oocyte ال maturation of
+
+505
+00:37:29,680 --> 00:37:34,520
+oocyte what is the side effect of gonadotropin
+
+506
+00:37:34,520 --> 00:37:37,320
+releasing hormone agonist؟ هل هو إله side effect؟
+
+507
+00:37:37,320 --> 00:37:41,260
+أكيد إله side effect لإن أنا بعطي السيدة hormone
+
+508
+00:37:41,260 --> 00:37:44,900
+بعطيها hormone exogenous hormone فبالتالي هيكون
+
+509
+00:37:44,900 --> 00:37:49,480
+عندها side effect منها hot flush انه بقت من الحمّة
+
+510
+00:37:50,630 --> 00:37:53,690
+في عندها dryness في الفاجينة، في عندها headache،
+
+511
+00:37:53,690 --> 00:37:58,310
+fatigue، في عندها sweating في مرحلة الليل، في
+
+512
+00:37:58,310 --> 00:38:01,570
+عندها مشاكل في ال mood، ال mood غير متزن، أعصابية،
+
+513
+00:38:01,570 --> 00:38:06,390
+tension، قلقة، بتكون، في عندها decrease في ال bone
+
+514
+00:38:06,390 --> 00:38:11,270
+mineral density عندها كثافة الإظام لحد ما بتكون
+
+515
+00:38:11,270 --> 00:38:15,810
+قليلة أو تميل إلى عدم وجود mineral فيها، هذا
+
+516
+00:38:15,810 --> 00:38:18,810
+المقصود فيها طبعا الولادة الروبيين اللي لازم هرمون
+
+517
+00:38:18,810 --> 00:38:23,100
+agonistهذا كل اللي حكينا فيه عشر إلى خمس عشر يوم
+
+518
+00:38:23,100 --> 00:38:25,280
+وممكن أبدأ في اليوم الواحد وعشرين من الدورة
+
+519
+00:38:25,280 --> 00:38:28,420
+السابقة أو اليوم السادس من الدورة الحالية كله
+
+520
+00:38:28,420 --> 00:38:31,500
+علاقة بالـ long protocol تعالوا شوفوا ال short
+
+521
+00:38:31,500 --> 00:38:37,180
+protocol the continuous for a duration of two week
+
+522
+00:38:37,180 --> 00:38:41,800
+required patient to take a drug to stimulate the
+
+523
+00:38:41,800 --> 00:38:47,120
+ovaries for just five to nine days before a
+
+524
+00:38:47,120 --> 00:38:53,490
+collection rather than five4 to 5 days in long
+
+525
+00:38:53,490 --> 00:38:57,190
+protocol خدوا بالك و بيقول هنا في الـ gonadotropin
+
+526
+00:38:57,190 --> 00:39:00,270
+-releasing hormone agonist الـ long protocol بياخد
+
+527
+00:39:00,270 --> 00:39:04,490
+خمس أسابيع ال short protocol بياخد أسبوعين فقط
+
+528
+00:39:04,490 --> 00:39:09,450
+لغيره شوفت الفرق من خمس أسابيع لأسبوعين في ال long
+
+529
+00:39:09,450 --> 00:39:15,460
+protocol خمس أسابيعخمس أسابيع يوم يوم هتاخد الزوجة
+
+530
+00:39:15,460 --> 00:39:20,020
+أو السيدة induction إبر حتى وصول إلى مرحلة التفجير
+
+531
+00:39:20,020 --> 00:39:24,820
+والمقصود بالتفجير يعني ال ovulation هذا في ال long
+
+532
+00:39:24,820 --> 00:39:27,780
+في ال short protocol و notropine releasing hormone
+
+533
+00:39:27,780 --> 00:39:33,640
+agonist أسبوعين أسبوعين بتشمل ال down regulation و
+
+534
+00:39:33,640 --> 00:39:39,120
+بتشمل ال ovulation أيضافترة زمنية قوية هنا صورة
+
+535
+00:39:39,120 --> 00:39:43,920
+بتوضح الكلام اللي احنا حكينا من حيث عملية ال
+
+536
+00:39:43,920 --> 00:39:48,360
+duration لو انا عندي هذه اليوم 21 من الدورة
+
+537
+00:39:48,360 --> 00:39:52,760
+السابقة ال past cycle ال past menstrual cycle
+
+538
+00:39:52,760 --> 00:39:59,640
+الدورة الحالية 1 لحد دي اليوم 11 وهو يوم التفجير
+
+539
+00:39:59,640 --> 00:40:05,080
+اعتبره ال long protocol بدأ من يوم ال long
+
+540
+00:40:05,080 --> 00:40:11,230
+protocol بدأ منيوم 21 من الدورة السابقة فاخد عندي
+
+541
+00:40:11,230 --> 00:40:17,110
+21 و22 و23 و24 و25 و26 و27 و28 تمام أيام من الدورة
+
+542
+00:40:17,110 --> 00:40:21,550
+السابقة وكمان أخد عشر أيام من الدورة الحالية يعني
+
+543
+00:40:21,550 --> 00:40:27,030
+ما يقارب 18 يوم يعني تقريبا تلات أسابيع هذا بيسموه
+
+544
+00:40:27,030 --> 00:40:31,930
+long protocol ال short protocol بدأ فقط لغير من
+
+545
+00:40:31,930 --> 00:40:38,810
+اليوم مثلا التالت من الدورة الحاليةلحد دي عشر أيام
+
+546
+00:40:38,810 --> 00:40:44,390
+يعني تقريبا أسبوع إلا شوية ال ultra short ما بياخد
+
+547
+00:40:44,390 --> 00:40:48,310
+فترة زمنية طويلة جدا في ال stimulation ما بياخد
+
+548
+00:40:48,310 --> 00:40:51,970
+فترة زمنية طويلة جدا في ال stimulation هذه الفرق
+
+549
+00:40:51,970 --> 00:40:56,370
+بين ال long و ال short و ال ultra short ال started
+
+550
+00:40:56,370 --> 00:41:01,010
+point وين هل ال 21 من الدورة السابقة و لا اليوم
+
+551
+00:41:01,010 --> 00:41:07,480
+الأول من الدورة السابقة و لا اليومالسادس من الدورة
+
+552
+00:41:07,480 --> 00:41:12,520
+الحالية هذه اللي احنا بنحكي عنها ايش الفرق ما بين
+
+553
+00:41:12,520 --> 00:41:17,020
+ال long و ال short protocol خلينا نشوف ال short
+
+554
+00:41:17,020 --> 00:41:21,280
+protocol شو هو بناء على الفيديو وبعدين ننتقل ال
+
+555
+00:41:21,280 --> 00:41:26,980
+long protocol كمقارنة بسيطةفي الأيام الأولى من
+
+556
+00:41:26,980 --> 00:41:30,500
+المدرسة، تم التحقق من مدرسة الاندومتريام من مصفحة
+
+557
+00:41:30,500 --> 00:41:34,100
+الهوتران والتعامل مع موجودة من السيستات في
+
+558
+00:41:34,100 --> 00:41:38,120
+الـRacin
+
+559
+00:41:38,120 --> 00:41:44,620
+إذا
+
+560
+00:41:44,620 --> 00:41:48,500
+كانت كل شيء عادي، يتم تحقيق الـGnRH-Analog Agonist
+
+561
+00:41:49,720 --> 00:41:54,820
+1 أو 2 أيام لاحقاً تبدأ استخدام الهورمون FSH في
+
+562
+00:41:54,820 --> 00:42:01,200
+اليوم اليوم اليوم يومي
+
+563
+00:42:01,200 --> 00:42:02,860
+يومي يومي يومي يومي يومي يومي
+
+564
+00:42:06,690 --> 00:42:10,030
+في نهاية أقل من 4 إلى 6 أيام من التدخل، يتم تجاربه
+
+565
+00:42:10,030 --> 00:42:13,690
+مرة أخرى لتحقق رقمه ومعمومته من الفوليكولات
+
+566
+00:42:13,690 --> 00:42:18,130
+ومعمومته من الاندومتريا كل 2 أو 3 أيام، يتم تجاربه
+
+567
+00:42:18,130 --> 00:42:21,050
+مرة أخرى لتحقيق الـ Ultrasound عندما تكون أقل من 3
+
+568
+00:42:21,050 --> 00:42:26,350
+فوليكولات أكبر إلى أقل من 18 ميليمتر، يتم تحريكه
+
+569
+00:42:26,350 --> 00:42:28,770
+بالهورمون HCG
+
+570
+00:42:32,660 --> 00:42:35,500
+Oocyte recovery is undertaken 36 hours later.
+
+571
+00:42:35,960 --> 00:42:38,640
+Following the procedure, daily administration of
+
+572
+00:42:38,640 --> 00:42:41,720
+the hormone progesterone is given vaginally. Two
+
+573
+00:42:41,720 --> 00:42:44,560
+to five days after oocyte recovery, the embryos
+
+574
+00:42:44,560 --> 00:42:48,020
+are transferred. Two weeks later, a pregnancy test
+
+575
+00:42:48,020 --> 00:42:52,580
+is performed طبعا هنا بتحكي عن شغلة، شايفين هنا في
+
+576
+00:42:52,580 --> 00:42:55,060
+عيني، سماها gonadotropin-releasing hormone
+
+577
+00:42:55,060 --> 00:42:59,680
+Analogues بعدين أعطى ال FH اللي بتعمل stimulation
+
+578
+00:42:59,680 --> 00:43:04,400
+و inductionولمّا نوصلت الفولك الـ 18 ميلي متر و هي
+
+579
+00:43:04,400 --> 00:43:07,980
+عبارة عن ال .. ال .. ال diameter المسموح بعملية
+
+580
+00:43:07,980 --> 00:43:12,980
+الإبادة أعطى ما يُعرف الـ RHCG وهو عبارة عن human
+
+581
+00:43:12,980 --> 00:43:17,220
+chronic gonadotropin ولكن recombinant وعمله يشبه
+
+582
+00:43:17,220 --> 00:43:21,780
+عمل الـ LH وهو عبارة عن ال ovulation بعد كده أعطى
+
+583
+00:43:21,780 --> 00:43:25,560
+لبروجسترون بعد عملية ال embryo transfer من أجل
+
+584
+00:43:25,560 --> 00:43:28,820
+تثبيت عملية الحمل إن وجدت
+
+585
+00:43:37,790 --> 00:43:41,790
+هذا الـ long protocol طبعا بدأ من long protocol
+
+586
+00:43:41,790 --> 00:43:47,190
+هيبدأ من اليوم رقم 21 من الدورة السابقة وصولا إلى
+
+587
+00:43:47,190 --> 00:43:51,350
+اليوم 13 او 12 لعملية ال ovulation بعد كده ال
+
+588
+00:43:51,350 --> 00:43:58,120
+embryo transfer و خلافهالـ GnRH-Analog أغانيست يتم
+
+589
+00:43:58,120 --> 00:44:01,820
+استخدامه بشكل نسوي أو بشكل أساسي من اليوم الـ 21
+
+590
+00:44:01,820 --> 00:44:02,000
+من عملية عملية عملية عملية عملية عملية الـ
+
+591
+00:44:02,000 --> 00:44:05,780
+Menstrual Cycle.بالتالي، بسبب تأثير الـ LH الأول،
+
+592
+00:44:05,780 --> 00:44:09,480
+تم إطلاق الـ Pituity للـ LH والذلك يقوم بتحرير
+
+593
+00:44:09,480 --> 00:44:09,980
+عملية عملية عملية عملية عملية العملية الـ LH بشكل
+
+594
+00:44:09,980 --> 00:44:10,400
+أساسي لتحرير عملية عملية عملية عملية العملية
+
+595
+00:44:10,400 --> 00:44:11,640
+العملية العملية العملية العملية العملية العملية
+
+596
+00:44:11,640 --> 00:44:11,980
+العملية العملية العملية العملية العملية العملية
+
+597
+00:44:11,980 --> 00:44:13,140
+العملية العملية العملية العملية العملية العملية
+
+598
+00:44:13,140 --> 00:44:17,360
+العملية العملية العملفي وقت الإستعمار، يتم إتجار
+
+599
+00:44:17,360 --> 00:44:21,760
+صورة لتحقق أضعف الـEndometrium في المخزن الدوري،
+
+600
+00:44:21,760 --> 00:44:31,080
+ويقوم بإدخال موجودة من الـCysts في الأعضاء.إذا
+
+601
+00:44:31,080 --> 00:44:36,220
+كانت كل شيء عاديًا، يتم إدخال تدخلات FSH بسرعة
+
+602
+00:44:36,220 --> 00:44:38,650
+أساسيةهذا الهورمون يساعد على اكتشاف عبارة عن عبارة
+
+603
+00:44:38,650 --> 00:44:38,990
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+604
+00:44:38,990 --> 00:44:39,650
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+605
+00:44:39,650 --> 00:44:40,950
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+606
+00:44:40,950 --> 00:44:42,770
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+607
+00:44:42,770 --> 00:44:49,290
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+608
+00:44:49,290 --> 00:44:49,910
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+609
+00:44:49,910 --> 00:44:52,990
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+610
+00:44:52,990 --> 00:44:56,370
+عبارة
+
+611
+00:44:56,370 --> 00:44:58,430
+عن عب
+
+612
+00:45:00,760 --> 00:45:04,840
+كل 2 أو 3 أيام يتم تجريب جرس جديد، عندما يكوّن أقل
+
+613
+00:45:04,840 --> 00:45:08,960
+من 3 فوليكولات أكتر إلى أقل من 18 ميلي مترأخيرًا،
+
+614
+00:45:08,960 --> 00:45:14,400
+تشغّل مادة الفلائكولات مع هرمون HCG، الفلائكولات
+
+615
+00:45:14,400 --> 00:45:16,960
+الموجودة داخل الفلائكولات ستبدأ في التطور التجارب
+
+616
+00:45:16,960 --> 00:45:21,860
+الأمريكية يتعامل 36 ساعات لاحقًا، وبالتالي، يتم
+
+617
+00:45:21,860 --> 00:45:24,300
+إعادة الهرمون البروجيسترون يتم إعادة الهرمون
+
+618
+00:45:24,300 --> 00:45:27,720
+البروجيسترون بشكل عقلي، و2 إلى 5 أيام بعد التعامل
+
+619
+00:45:27,720 --> 00:45:29,460
+مع الهرمون الأمريكي، يتم إعادة التعامل مع الهرمون
+
+620
+00:45:29,460 --> 00:45:31,020
+البروجيسترون بشكل عقلي، و2 أيام لاحقًا، يتم إعادة
+
+621
+00:45:31,020 --> 00:45:34,730
+التعامل مع الهرمون البروجيسترون بشكل عقليفي كل
+
+622
+00:45:34,730 --> 00:45:37,310
+المرحلة من البداية حتى النهاية من مرحلة ال
+
+623
+00:45:37,310 --> 00:45:41,970
+induction حتى مرحلة ال beta CG analysis أنا بحكي
+
+624
+00:45:41,970 --> 00:45:45,030
+على ال long protocol تحت مصطلح gonadotropin
+
+625
+00:45:45,030 --> 00:45:48,690
+-releasing hormone analogues agonist أعطاها في
+
+626
+00:45:48,690 --> 00:45:52,290
+اليوم ال 21 من الدورة السابقة من أجل تحفيز ال
+
+627
+00:45:52,290 --> 00:45:54,870
+antiloid loop للبتيوتر gland لإنتاج الأفسادش
+
+628
+00:45:54,870 --> 00:45:57,770
+والألاتش بعد كده عملها dropping أو down or
+
+629
+00:45:57,770 --> 00:46:02,340
+shutdown أو down regulation فبطلت تفرزبعد كده عمل
+
+630
+00:46:02,340 --> 00:46:06,900
+عملية scanning لل ovary شاف ال endomaterium أو
+
+631
+00:46:06,900 --> 00:46:11,100
+بطانة الرحم نمت بشكل .. في استجابة ولا لأ؟ إذا لجأ
+
+632
+00:46:11,100 --> 00:46:13,600
+في استجابة هيبدأ يعطيها ال recomponent of a such
+
+633
+00:46:13,600 --> 00:46:19,280
+حتى اليوم ال 12 كل تلت أيام أو كل يومين بصور بشوف
+
+634
+00:46:19,280 --> 00:46:25,290
+وضع المبيضكيف هو؟ هل استجاب لهرمون علشان يظبط
+
+635
+00:46:25,290 --> 00:46:28,110
+الدوز؟ ممكن في بعض الأحيان نلاقي الاستجابة سريعة
+
+636
+00:46:28,110 --> 00:46:31,750
+فبيقلل الدوز الاستجابة بطيقة فبيزود الدوز الطبيب
+
+637
+00:46:31,750 --> 00:46:35,030
+هذا من خلال حاجة بنسميها الـ E2 level و الـ
+
+638
+00:46:35,030 --> 00:46:39,430
+Estrogen يعني و تصوير الرحم مع تصوير المبيض و
+
+639
+00:46:39,430 --> 00:46:43,050
+الفوليكل إذا الفوليكل عدد من الفوليكل أقل شيء
+
+640
+00:46:43,050 --> 00:46:46,550
+تلاتة فوليكل وصلوا إلى الـ Diameter المطلوب على 18
+
+641
+00:46:46,550 --> 00:46:50,990
+Millimeter يعني معناه فيه mature oocyteهيعطيها
+
+642
+00:46:50,990 --> 00:46:54,570
+للزوجة ما يُعرف باسم أو للسيدة ما يُعرف باسم الـ
+
+643
+00:46:54,570 --> 00:46:59,850
+Recombinant HCG الذي يعمل عملية الـ ovulation بعد
+
+644
+00:46:59,850 --> 00:47:03,750
+كده بيصير pancture أنه بيعمل aspiration للـ oocyte
+
+645
+00:47:03,750 --> 00:47:07,430
+بعدين بيعملها تلقيح بعد يومين تلاتة بيعمل embryo
+
+646
+00:47:07,430 --> 00:47:11,170
+transfer و بعد أسبوعين بيعمل pregnancy test علشان
+
+647
+00:47:11,170 --> 00:47:14,490
+نشوف ال beta HCG قداشي ال level تبعها ولكن بعد ما
+
+648
+00:47:14,490 --> 00:47:18,230
+يعمل embryo transfer لازم يعطي البروجيسترون علشان
+
+649
+00:47:18,230 --> 00:47:22,490
+يزيدمن تثبيت والـ implantation rate اللي احنا
+
+650
+00:47:22,490 --> 00:47:26,730
+بنسميها حبوب التثبيت او اغار التثبيت هي عبارة عن
+
+651
+00:47:26,730 --> 00:47:32,250
+هرمون لبروجسترون هذه فكرة الـ long protocol و
+
+652
+00:47:32,250 --> 00:47:35,610
+short protocol المتعلق بالـ gonadotropin releasing
+
+653
+00:47:35,610 --> 00:47:40,030
+hormone agonist so what is the advantage of short
+
+654
+00:47:40,030 --> 00:47:43,650
+protocol؟ ال advantage of short protocol ان انا ما
+
+655
+00:47:43,650 --> 00:47:48,070
+بجهد افضل ال advantage of short protocol أول شغلة
+
+656
+00:47:48,290 --> 00:47:51,050
+إن أنا بيصير عندي reduction في ال chance of a
+
+657
+00:47:51,050 --> 00:47:55,430
+premature and low birth weight baby بيصير عندي
+
+658
+00:47:55,430 --> 00:47:58,490
+reduction في ال risk of ovarian hyper stimulation
+
+659
+00:47:58,490 --> 00:48:03,590
+syndrome بيصير أكثر تركيزا على البويضات الناضجة
+
+660
+00:48:03,590 --> 00:48:08,170
+لوحدها بشكل طبيعي ولكن تحتاج إلى تدقيم قليل لأن في
+
+661
+00:48:08,170 --> 00:48:11,310
+بويضات بتكون ناضج طبيعي ولكن تحتاج إلى dose بسيطة
+
+662
+00:48:11,310 --> 00:48:16,030
+علشان تنضج وتنمو فهذه بتكون ال quality تبعتها جيدة
+
+663
+00:48:16,030 --> 00:48:19,900
+جدا، بتكون matureوhigh equality it is more
+
+664
+00:48:19,900 --> 00:48:24,860
+inexpensive because we used low dose of medication
+
+665
+00:48:24,860 --> 00:48:27,980
+reducing the cost of treatment يعني فيه علاقة بال
+
+666
+00:48:27,980 --> 00:48:31,700
+equality of mature oocyte في علاقة بانقاس معدل
+
+667
+00:48:31,700 --> 00:48:37,120
+حدوث ال pre mature baby في علاقة بانقاس معدل حدوث
+
+668
+00:48:37,120 --> 00:48:40,520
+ال ovarian hyperstimulation syndrome بالاضافة إلى
+
+669
+00:48:40,520 --> 00:48:45,780
+أن تكلفته قليلة إلى حد ما سوف نكتفي بهذا القدر في
+
+670
+00:48:45,780 --> 00:48:50,230
+محاضرة اليومعلى أمل أن نلتقي في محاضرات قادمة ان
+
+671
+00:48:50,230 --> 00:48:50,770
+شاء الله
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/VNoCop9C_V4.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/VNoCop9C_V4.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b19cfd6dd48577c17f51aecaca324f7bef6134bb
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/VNoCop9C_V4.srt
@@ -0,0 +1,1599 @@
+1
+00:00:00,000 --> 00:00:04,480
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:04,480 --> 00:00:09,580
+المرسلين سيدنا محمد وعلى آله وصحبه أجمعين، طلبتنا 
+
+3
+00:00:09,580 --> 00:00:13,500
+الأعزاء، نرجو من الله الكريم أن تكونوا بصحة جيدة
+
+4
+00:00:13,500 --> 00:00:18,480
+وبكل خير، اليوم سوف نستكمل ما بدأنا فيه من 
+
+5
+00:00:18,480 --> 00:00:22,340
+stimulation protocol، what is the difference
+
+6
+00:00:22,340 --> 00:00:24,680
+between agonist and antagonist؟ what is the
+
+7
+00:00:24,680 --> 00:00:27,800
+difference between long, short, ultra short protocol؟
+
+8
+00:00:28,380 --> 00:00:32,100
+تحدثنا في المحاضرة السابقة عن الـ Gonadotropin
+
+9
+00:00:32,100 --> 00:00:36,420
+-releasing hormone agonist protocol، وقلنا أن هذا
+
+10
+00:00:36,420 --> 00:00:39,940
+الـ protocol ينقسم إلى long و short و ultra short 
+
+11
+00:00:39,940 --> 00:00:43,940
+بناء على الـ duration time، وحكينا إن فكرته
+
+12
+00:00:43,940 --> 00:00:48,640
+ببساطة إن أنا بعطي السيدة gonadotropin-releasing
+
+13
+00:00:48,640 --> 00:00:52,560
+hormone analogues، وظيفتها الأساسية بتعمل induction
+
+14
+00:00:52,560 --> 00:00:56,540
+و inducing و stimulation للـ anterior loop، بقصد 
+
+15
+00:00:56,540 --> 00:01:01,320
+تحفيزها من أجل إفراز الـ native FSH والـ LH، بعد فترة 
+
+16
+00:01:01,320 --> 00:01:05,860
+زمانية باستمرار الـ injection، بيصير down regulation
+
+17
+00:01:05,860 --> 00:01:10,600
+للـ anterior loop، مما يؤهلني إلى إعطاء الـ Recombinant FSH 
+
+18
+00:01:10,600 --> 00:01:16,660
+بدوز معين ولفترة زمانية معينة، تتعلق وتعتمد على 
+
+19
+00:01:17,150 --> 00:01:22,110
+البطانة الرحم كيف وضعها ومدى استجابة المبيض، عندما 
+
+20
+00:01:22,110 --> 00:01:25,490
+تصل الفوليكل إلى أقل شيء تلاتة فوليكل وصلت إلى 
+
+21
+00:01:25,490 --> 00:01:31,710
+الـ diameter أكبر من أو يساوي 18 ملم، ساعتها بعطي
+
+22
+00:01:31,710 --> 00:01:35,430
+الـ injection اللي اسمه hCG، human corona
+
+23
+00:01:35,430 --> 00:01:39,130
+gonadotropin، اللي بيعمل عمل الـ LH واللي بيساعد على 
+
+24
+00:01:39,130 --> 00:01:43,230
+الـ ovulation، هذه فكرة الـ gonadotropin releasing
+
+25
+00:01:43,230 --> 00:01:47,210
+hormone agonist، اليوم نتكلم عن الـ Gonadotropin
+
+26
+00:01:47,210 --> 00:01:51,010
+Releasing Hormone Antagonist، وكلاهما يستخدم 
+
+27
+00:01:51,010 --> 00:01:54,630
+Gonadotropin Releasing Hormone Analogues من أجل 
+
+28
+00:01:54,630 --> 00:01:58,130
+تحفيز الـ anterior loop of pituitary gland، الـ 
+
+29
+00:01:58,130 --> 00:02:00,490
+Gonadotropin Releasing Hormone Antagonist
+
+30
+00:02:00,490 --> 00:02:03,350
+reversible binding to Gonadotropin Releasing 
+
+31
+00:02:03,350 --> 00:02:07,210
+Hormone Receptor and prevent the releasing of FSH
+
+32
+00:02:07,210 --> 00:02:11,270
+and LH، يعني هذا الـ protocol اللي أنا بستخدمه
+
+33
+00:02:11,270 --> 00:02:15,430
+بيحفظ الـ anterior loop و الـ pituitary gland لأن
+
+34
+00:02:15,430 --> 00:02:20,730
+بيعملها blocking بشكل مباشر وبشكل سريع من خلال
+
+35
+00:02:20,730 --> 00:02:25,430
+ارتباط مادة معينة مع الـ receptor اللي لها علاقة
+
+36
+00:02:25,430 --> 00:02:28,790
+بالـ gonadotropin-releasing hormone receptor مما
+
+37
+00:02:28,790 --> 00:02:32,810
+يؤدي إلى امتناع الـ loop الخاصة بالـ pituitary
+
+38
+00:02:32,810 --> 00:02:36,650
+gland، الـ anterior loop، من إفراز الـ FSH والـ LH
+
+39
+00:02:36,650 --> 00:02:41,500
+So, in the antagonist protocol, there is no down
+
+40
+00:02:41,500 --> 00:02:44,900
+regulation. A gonadotropin-releasing hormone
+
+41
+00:02:44,900 --> 00:02:48,480
+antagonist binds and blocks the receptor of
+
+42
+00:02:48,480 --> 00:02:51,580
+gonadotropin-releasing hormone in pituitary gland
+
+43
+00:02:51,580 --> 00:02:58,800
+.This action leads to immediately suppression of FSH
+
+44
+00:02:58,800 --> 00:03:03,380
+and LH releasing. يعني هنا الفرق إنه مافي اندي down
+
+45
+00:03:03,380 --> 00:03:06,720
+regulation، يعني inducing بعدين reduction، لأ في
+
+46
+00:03:06,720 --> 00:03:11,770
+اندي blocking بشكل مباشر من خلال إغلاق الـ Receptor 
+
+47
+00:03:11,770 --> 00:03:15,690
+الخاص بالـ FSH والـ LH. Gonadotropin-releasing
+
+48
+00:03:15,690 --> 00:03:19,730
+hormone antagonist has a long half-life and high
+
+49
+00:03:19,730 --> 00:03:22,990
+affinity binding to the receptor of gonadotropin 
+
+50
+00:03:22,990 --> 00:03:26,890
+releasing hormone، but without activating them or
+
+51
+00:03:26,890 --> 00:03:29,630
+activating them، صح إنه بيرتبط مع هذا الـ Receptor 
+
+52
+00:03:29,630 --> 00:03:34,610
+ولكن ما بيحفزه بخلاف الـ agonist. The gonadotropin
+
+53
+00:03:34,610 --> 00:03:37,790
+releasing hormone antagonist has immediate action on
+
+54
+00:03:37,790 --> 00:03:42,290
+the prevention of LH surge and requires a few
+
+55
+00:03:42,290 --> 00:03:46,990
+injections during the treatment cycle، ما بحتاج إلى
+
+56
+00:03:46,990 --> 00:03:54,230
+حقن متعدد، لأ حقن بسيطة جدا، معدودة for this
+
+57
+00:03:54,230 --> 00:03:58,830
+protocol. Gonadotropins are started on cycle day 2
+
+58
+00:03:58,830 --> 00:04:02,610
+in the cycle، day number 2. يعني هذا الـ protocol 
+
+59
+00:04:02,610 --> 00:04:06,090
+بتميز أنه يبدأ في اليوم الثاني، أو يمكن أن نبدأ فيه في
+
+60
+00:04:06,090 --> 00:04:10,110
+اليوم الثاني من الدورة، فمش محتاجين ناخد من اليوم رقم 
+
+61
+00:04:10,110 --> 00:04:14,490
+21 من الدورة السابقة، الـ advantage الخاصة فيه، fewer 
+
+62
+00:04:14,490 --> 00:04:19,270
+injections، زي ما اتكلمنا قبل شوية، بيعمل
+
+63
+00:04:19,270 --> 00:04:24,270
+suppression للـ FSH و للـ LH بشكل سريع، فبالتالي
+
+64
+00:04:24,270 --> 00:04:29,450
+بحتاج إلى injection وعدد قليل جدا، بيعمل reduction
+
+65
+00:04:29,450 --> 00:04:33,390
+في فرصة حدوث متلازمة الـ ovarian hyperstimulation 
+
+66
+00:04:33,390 --> 00:04:38,760
+syndrome، بعض الدراسات أو وجدت معلومات معينة ونتائج
+
+67
+00:04:38,760 --> 00:04:42,100
+معينة، على سبيل المثال وجدت أن الـ gonadotropin
+
+68
+00:04:42,100 --> 00:04:47,420
+releasing hormone antagonist was effectiveness 
+
+69
+00:04:47,420 --> 00:04:51,340
+as gonadotropin-releasing hormone analogues for
+
+70
+00:04:51,340 --> 00:04:56,420
+prevention of premature LH surge، يعني وجدوا أن
+
+71
+00:04:56,420 --> 00:05:02,440
+كفاءته، الـ effectiveness، طبعا، على منع الـ premature
+
+72
+00:05:02,440 --> 00:05:10,650
+LH surge أعلى من الـ agonist، أيضًا 
+
+73
+00:05:10,650 --> 00:05:14,010
+احتمالية الحصول على الـ pregnancy، clinical
+
+74
+00:05:14,010 --> 00:05:18,970
+pregnancy، وجدوا rate was shown to be lower than
+
+75
+00:05:18,970 --> 00:05:21,750
+gonadotropin releasing hormone antagonist group،
+
+76
+00:05:21,750 --> 00:05:25,310
+وجدوا أن الـ pregnancy rate عند استخدام الـ
+
+77
+00:05:25,310 --> 00:05:28,950
+gonadotropin releasing hormone antagonist أقل، أيضًا
+
+78
+00:05:28,950 --> 00:05:32,530
+there is no difference in the live birth rate، يعني
+
+79
+00:05:32,530 --> 00:05:37,250
+هذه تعتبر دراسات، بعضهم قال أن والله الـ antagonist 
+
+80
+00:05:37,250 --> 00:05:40,510
+أفضل من الـ agonist، بعضهم قال مافيش اختلاف ما بينهم،
+
+81
+00:05:40,510 --> 00:05:43,450
+و بعض قال لأ، والله الـ pregnancy rate as a clinical
+
+82
+00:05:43,450 --> 00:05:47,250
+pregnancy rate في الـ antagonist أقل من الـ agonist،
+
+83
+00:05:47,250 --> 00:05:52,550
+فبتختلف الدراسات بناء على طبيعة الدراسة في
+
+84
+00:05:52,550 --> 00:05:55,750
+ND2 protocol، خاصة بالـ antagonist، الـ protocol الأول
+
+85
+00:05:55,750 --> 00:05:59,050
+اسمه single dose protocol، و الـ protocol الثاني
+
+86
+00:05:59,050 --> 00:06:02,690
+اسمه multiply dose protocol، بالـ Single dose
+
+87
+00:06:02,690 --> 00:06:06,130
+protocol، أنا بعطي dose واحد بمعدل تلاتة milligram 
+
+88
+00:06:06,130 --> 00:06:12,750
+في مرحلة الـ late follicular stage، في الـ multiple
+
+89
+00:06:12,750 --> 00:06:16,470
+dose، أنا بعطي أكثر من dose بشكل يومي بمعدل ربع 
+
+90
+00:06:16,470 --> 00:06:19,850
+milligram من الـ analogues اللي هي عبارة عن gonadotropin 
+
+91
+00:06:19,850 --> 00:06:22,850
+releasing hormone analogues، تبدأ في اليوم
+
+92
+00:06:22,850 --> 00:06:26,010
+الخامس أو السادس من الدورة، هذا الفرق بين الـ single
+
+93
+00:06:26,010 --> 00:06:31,950
+dose و multiple dose protocol، صورة بتوضح الفرق بين 
+
+94
+00:06:31,950 --> 00:06:34,490
+الـ agonist و الـ antagonist، لو بدأت أنا من الـ
+
+95
+00:06:34,490 --> 00:06:37,490
+agonist، هي الـ hypothalamus، هي الـ pituitary gland
+
+96
+00:06:37,490 --> 00:06:40,150
+هي الـ receptor الخاص بالـ gonadotropin releasing
+
+97
+00:06:40,150 --> 00:06:44,650
+hormone receptor، أنا هنا باعطي gonadotropin
+
+98
+00:06:44,650 --> 00:06:47,710
+releasing hormone analogues، هترتبط بالـ receptor 
+
+99
+00:06:47,710 --> 00:06:51,190
+فهتحفز الـ receptor الموجودة على الـ anterior loop
+
+100
+00:06:51,190 --> 00:06:53,490
+فبتدفع الـ anterior loop و الـ pituitary gland
+
+101
+00:06:53,490 --> 00:06:58,290
+لإفراز كمية كبيرة جدا من الـ FSH والـ LH، في لحظة 
+
+102
+00:06:58,290 --> 00:07:05,030
+معينة تتوقف، بتبطل تفرز الـ FSH و الـ LH، أنا كطبيب ببدأ
+
+103
+00:07:05,030 --> 00:07:09,230
+أعطي الـ recombinant FSH، هذا ما نسميه agonist.
+
+104
+00:07:09,230 --> 00:07:14,790
+الـ antagonist، لأ، مباشرة المادة اللي بتتحقن تعمل
+
+105
+00:07:14,790 --> 00:07:18,290
+blocking للـ receptor الموجودة في الـ pituitary
+
+106
+00:07:18,290 --> 00:07:22,490
+gland، فتعمل على إيقاف الـ gonadotropin releasing
+
+107
+00:07:22,490 --> 00:07:29,150
+hormone، like FSH and LH، فبالتالي بعطي مباشرة الـ
+
+108
+00:07:29,150 --> 00:07:32,030
+recombinant FSH من الخارج، هذا الفرق بين الـ
+
+109
+00:07:32,030 --> 00:07:38,150
+agonist و الـ antagonist. طيب، بعد ما عرفنا الفرق بين 
+
+110
+00:07:38,150 --> 00:07:43,230
+الـ agonist و الـ antagonist، صورة بتوضح و بتعمل 
+
+111
+00:07:43,230 --> 00:07:47,290
+summarization لكل الـ information اللي احنا اتكلمنا 
+
+112
+00:07:47,290 --> 00:07:51,850
+عنها سابقًا، فلو أنا بدأت، لو نفرض أن عندي هي اليوم 
+
+113
+00:07:51,850 --> 00:07:55,470
+الأول من الدورة، و هذه الأيام السابقة من الدورة 
+
+114
+00:07:55,470 --> 00:08:01,500
+السابقة، في الـ ultra short و short و long، و long
+
+115
+00:08:01,500 --> 00:08:06,420
+mid-luteal protocol، و agonist، هذا كله... عفواً، هذا 
+
+116
+00:08:06,420 --> 00:08:09,940
+antagonist، هذا كله agonist، اللي فوق الـ ultra short
+
+117
+00:08:09,940 --> 00:08:13,980
+لحد دي الـ long، هذا كله agonist، في الـ ultra short
+
+118
+00:08:13,980 --> 00:08:17,600
+بدأ من اليوم الأول للدورة، أعطي gonadotropin
+
+119
+00:08:17,600 --> 00:08:21,400
+releasing hormone analogues تلت أيام، بعضين أعطي 
+
+120
+00:08:21,400 --> 00:08:27,030
+FSH، بعضين في اليوم العاشر أعطي الـ human chorionic
+
+121
+00:08:27,030 --> 00:08:30,790
+gonadotropin اللي بيعمل ovulation، فوجدت أخد أيام
+
+122
+00:08:30,790 --> 00:08:37,270
+تقريبا 10 أيام، في الـ short اختلف الموضوع، أعطي
+
+123
+00:08:37,270 --> 00:08:42,430
+Analogues تلت أيام من الدورة، بعدين أعطي FSH plus
+
+124
+00:08:42,430 --> 00:08:45,090
+gonadotropin releasing hormone Analogues، علشان
+
+125
+00:08:45,090 --> 00:08:49,050
+يستمر في تحفيز الـ anterior loop of pituitary gland
+
+126
+00:08:49,050 --> 00:08:53,150
+من أجل إنتاج الـ FSH و الـ LH، لما نصل إلى الـ
+
+127
+00:08:53,150 --> 00:08:58,410
+Downregulation، حيس يعطي الـ Recombinant FSH ويصل
+
+128
+00:08:58,410 --> 00:09:02,450
+لـ diameter المطلوب للفوليكل، من أجل إعطاء الـ Human
+
+129
+00:09:02,450 --> 00:09:06,650
+Corona Gonadotropin، في الـ Long Protocol المفروض
+
+130
+00:09:06,650 --> 00:09:09,990
+في الـ Long Protocol، عندي نوعين Long Protocol، في
+
+131
+00:09:09,990 --> 00:09:13,210
+الـ Follicular Stage، و Long Protocol في الـ Middle
+
+132
+00:09:13,210 --> 00:09:17,210
+Luteal Stage، Long Protocol في الـ Follicular ببدأ
+
+133
+00:09:17,210 --> 00:09:21,010
+من اليوم الأول من الدورة الحالية، هيعطي Analogues 
+
+134
+00:09:21,010 --> 00:09:26,800
+لمدة 13 يوم أو 12 يوم، بعدين بمجرد ما يصير down
+
+135
+00:09:26,800 --> 00:09:31,280
+regulation، هيعطي الـ recombinant FSH، بمجرد الـ follicle
+
+136
+00:09:31,280 --> 00:09:35,040
+اللي ما تصل إلى 18 ملم أو أكبر، هيعطي الـ HCG، 
+
+137
+00:09:35,040 --> 00:09:39,420
+اللي سميتها هي human chorionic gonadotropin اللي
+
+138
+00:09:39,420 --> 00:09:44,310
+بيشتغل شغل الـ LH، وهي الـ ovulation، في الـ Long 
+
+139
+00:09:44,310 --> 00:09:48,230
+Middle Luteal Protocol، حيبدأ بإعطاء الجنادوتروبين 
+
+140
+00:09:48,230 --> 00:09:51,790
+Releasing Hormone Analogues، من آخر عشر أيام في 
+
+141
+00:09:51,790 --> 00:09:58,990
+الدورة السابقة ويستمر إلى اليوم السابع
+
+142
+00:09:58,990 --> 00:10:03,710
+من الدورة الحالية تجريبا اليوم السابع أو اليوم 
+
+143
+00:10:03,710 --> 00:10:07,690
+الثامن، اليوم السابع بعد كده، هيستمر بإعطاء
+
+144
+00:10:07,690 --> 00:10:10,830
+الجنادو تروبين Releasing Hormone حتى يصل إلى مرحلة
+
+145
+00:10:10,830 --> 00:10:14,310
+الـ Down Regulation of the anterior pituitary gland
+
+146
+00:10:14,310 --> 00:10:19,450
+وقتها هيعطي الـ FSH من أجل إنضاج البويضات بمجرد 
+
+147
+00:10:19,450 --> 00:10:23,650
+البويضة ما تنضج وتنضج بشكل كامل وتصل الفولكل 
+
+148
+00:10:23,650 --> 00:10:28,330
+الأكبر من أو تصل إلى 18 مليمتر هيبدأ يعطي هرمون
+
+149
+00:10:28,330 --> 00:10:32,810
+مسئول عن عملية الـ ovulation هذه كلها الـ protocol
+
+150
+00:10:32,810 --> 00:10:36,530
+هذه الأربع اللي حكينا عنها هي عبارة عن
+
+151
+00:10:36,530 --> 00:10:42,200
+Gonadotropin Releasing Hormone agonist نأتي للـ
+
+152
+00:10:42,200 --> 00:10:46,080
+Antagonist الـ Antagonist ما في عندي Analogues
+
+153
+00:10:46,080 --> 00:10:49,580
+بمعنى آخر، ما في عندي Down Regulation في عندي
+
+154
+00:10:49,580 --> 00:10:55,460
+مباشرة Blocking للـ Receptor الخاصة بالـ FSH
+
+155
+00:10:55,460 --> 00:10:58,760
+واللاتش الموجودة في الـ Anterior Lobe فبيعطي FSH
+
+156
+00:10:58,760 --> 00:11:03,260
+مباشرة، بعدين بيعطي FSH Recombinant المسئولة عن
+
+157
+00:11:03,260 --> 00:11:06,920
+عملية إنضاج الفوليكل لما ينتصر الفوليكل للحد
+
+158
+00:11:06,920 --> 00:11:09,760
+المطلوب والدياميتر المطلوب، بيعطيها لـ Human
+
+159
+00:11:09,760 --> 00:11:13,750
+Chorionic Gonadotropin هذا المقصود فيها Antagonist 
+
+160
+00:11:13,750 --> 00:11:18,830
+الـ Agonist Stimulation Releasing Stopping الـ
+
+161
+00:11:18,830 --> 00:11:22,970
+Antagonist Stopping Directly Without Activation،
+
+162
+00:11:22,970 --> 00:11:28,070
+Without Stimulation هذا الفرق ما بين الاتنين طيب،
+
+163
+00:11:28,070 --> 00:11:32,990
+العملية إعطاء الجرعة هادي وإعطاء الهرمونات وإعطاء
+
+164
+00:11:32,990 --> 00:11:35,490
+الـ Analogues وإعطاء الـ F-Acetyl-Component
+
+165
+00:11:35,490 --> 00:11:38,050
+البروتين وإعطاء الـ Human Chorionic Gonadotropin
+
+166
+00:11:38,050 --> 00:11:42,090
+المسئول عن الـ Ovulation هل تحدث عبثاً؟ هل يجب أن 
+
+167
+00:11:42,090 --> 00:11:45,370
+تخضع إلى عملية monitoring؟ لا يجب أن تخضع إلى
+
+168
+00:11:45,370 --> 00:11:49,210
+عملية monitoring بشكل مستمر حتى بعض المختبرات و
+
+169
+00:11:49,210 --> 00:11:54,130
+بعض المراكز بتعمل monitoring يوم بيوم كل يوم لازم 
+
+170
+00:11:54,130 --> 00:11:58,590
+الزوجة تيجي تعمل E2 level examination وتعمل
+
+171
+00:11:58,590 --> 00:12:02,190
+vaginal ultrasound examination يعني أنا بحدد مستوى
+
+172
+00:12:02,190 --> 00:12:08,970
+الـ E2 وبأخذ صورة للأوبري والرحم بشكل مستمر بعد
+
+173
+00:12:08,970 --> 00:12:13,260
+الدراسات قالت E2 level is used to determine the
+
+174
+00:12:13,260 --> 00:12:16,800
+dose of gonadotropin and if under or over
+
+175
+00:12:16,800 --> 00:12:20,720
+stimulation okay يعني جدش أنا فيه عندي E2 جدش
+
+176
+00:12:20,720 --> 00:12:25,300
+المفروض يكون فيه عندي بويضة لأن كل بويضة بتفرز
+
+177
+00:12:25,300 --> 00:12:29,240
+كمية معينة من الـ E2 لو أنا حددت جدش عندي كمية الـ
+
+178
+00:12:29,240 --> 00:12:34,760
+E2 وجسمت على كمية الـ E2 المفرز من كل بويضة هعرف
+
+179
+00:12:34,760 --> 00:12:40,000
+تقريباً إلى حد اللي ما جدش عندي mature oocyte بعض
+
+180
+00:12:40,000 --> 00:12:45,300
+الدراسات قالت إن الـ E2 ليس له أهمية يكفي أن نعمل
+
+181
+00:12:45,300 --> 00:12:48,280
+monitoring من خلال ما يُعرف باسم الـ vaginal
+
+182
+00:12:48,280 --> 00:12:53,340
+ultrasound examination and so the E2 level is not
+
+183
+00:12:53,340 --> 00:12:56,520
+necessary is not always necessary and the response
+
+184
+00:12:56,520 --> 00:12:59,160
+to the treatment can be followed by ultrasound
+
+185
+00:12:59,160 --> 00:13:02,800
+monitoring only the goal for ovarian hyper
+
+186
+00:13:02,800 --> 00:13:07,740
+stimulation is to develop at least three mature
+
+187
+00:13:07,740 --> 00:13:14,410
+oocyte أو 3 mature follicle القطر أكبر من أو
+
+188
+00:13:14,410 --> 00:13:20,670
+يساوي 18 مليمتر بعضهم بيديني لأ بيكفلي 18 بدي يكون
+
+189
+00:13:20,670 --> 00:13:26,090
+القطر من 22 إلى 24 بس كحد أخدنا 18 ويطلع لازم
+
+190
+00:13:26,090 --> 00:13:31,530
+يكون الـ follicle as diameter 18 مليمتر طيب لما نصل
+
+191
+00:13:31,530 --> 00:13:36,020
+أو تصل الـ follicle لديامتر المطلوب نقتصر على القطر
+
+192
+00:13:36,020 --> 00:13:39,960
+المطلوب يكون 18 مليمتر الـ FSH والاخرى مدعومين
+
+193
+00:13:39,960 --> 00:13:44,880
+مستمرين والانجيكشن الوحيد من الـ Human Chorionic
+
+194
+00:13:44,880 --> 00:13:48,060
+Gonadotropin يجب أن يتم إعطاءه لتعامل الفوليكين ويسمح
+
+195
+00:13:48,060 --> 00:13:52,260
+له بفرتاليز يعني وصلت الفوليكين لحد المطلوب ووصلت
+
+196
+00:13:52,260 --> 00:13:56,420
+للقطر المطلوبة خلاص بوقف إعطاء الـ FSH والـ
+
+197
+00:13:56,420 --> 00:13:59,140
+medication الاخرى او الـ injection الاخرى وبعطي
+
+198
+00:13:59,140 --> 00:14:04,020
+injection واحدة بهرمون اسمه HCG hormone واضيف 
+
+199
+00:14:04,020 --> 00:14:07,730
+تقولنا تشبه وظيفة الـ LH وهي مسئولة عن الـ ovulation
+
+200
+00:14:07,730 --> 00:14:12,770
+الـ HCG for administration will be cause ovulation
+
+201
+00:14:12,770 --> 00:14:17,550
+so it is equal in the function like LH but this
+
+202
+00:14:17,550 --> 00:14:22,290
+does not occur until 36 to 40 hours after the
+
+203
+00:14:22,290 --> 00:14:26,750
+injection طبعا عملية الـ ovulation ما بتحدث بشكل
+
+204
+00:14:26,750 --> 00:14:31,430
+مباشر لا تحدث بعد 36 إلى 40 ساعة من الـ injection
+
+205
+00:14:31,430 --> 00:14:37,110
+يعني لو أنا أعطيت الزوجة الـ HCG الساعة 4 العصر عيد
+
+206
+00:14:37,110 --> 00:14:41,070
+36 ساعة إلى 40 ساعة خلال الفترة هذه لازم يصير عندي
+
+207
+00:14:41,070 --> 00:14:45,970
+ovulation therefore it is standard that the HCG
+
+208
+00:14:45,970 --> 00:14:49,990
+injection is administrated 36 hours before the
+
+209
+00:14:49,990 --> 00:14:55,230
+scheduled egg collected such that this will allow a
+
+210
+00:14:55,230 --> 00:14:58,790
+quiet maturation of the oocyte and yet there
+
+211
+00:14:58,790 --> 00:15:02,090
+would be little risk for ovulation علشان كده مهم
+
+212
+00:15:02,090 --> 00:15:05,130
+جدا أنت كإنسان بيشتغل في هذا المجال إنك تعمل 
+
+213
+00:15:05,130 --> 00:15:09,050
+schedule time table time أنا لو أعطيت السيدة هذه
+
+214
+00:15:09,050 --> 00:15:15,550
+الـ hcg الساعة كده الساعة الخامسة متى المفروض أجمع
+
+215
+00:15:15,550 --> 00:15:18,250
+البويضات الستة و تلاتين ساعة نهايتها متى هتكون 
+
+216
+00:15:18,250 --> 00:15:21,990
+علشان أشوف هل جدوى اللي بسمح ولا لا لأنه مش منطقي
+
+217
+00:15:21,990 --> 00:15:26,370
+أخليها بعد 36 ساعة أنتظر إنه ممكن يصير ovulation
+
+218
+00:15:26,370 --> 00:15:29,550
+أنا ما بدي يصير ovulation أنا بدي أصل إلى لحظة الـ
+
+219
+00:15:29,550 --> 00:15:32,710
+ovulation قبلها بقليل وأدخل بالإبرة الـ 
+
+220
+00:15:32,710 --> 00:15:38,070
+aspiration هاي المقصود بالموضوع أجي نا مصطلح مهم
+
+221
+00:15:38,070 --> 00:15:42,270
+جدا تكلمنا عنه باختصار شديد في البداية المحاضرة
+
+222
+00:15:42,270 --> 00:15:46,170
+السابقة وهي Ovarian Hyperstimulation Syndrome الـ
+
+223
+00:15:46,170 --> 00:15:48,770
+Ovarian Hyperstimulation Syndrome هو عبارة عن 
+
+224
+00:15:48,770 --> 00:15:53,910
+حالة ومظهر يحدث عند السيدات اللي ممكن يخضعوا للـ
+
+225
+00:15:53,910 --> 00:15:57,090
+injection أو الـ induction أو الـ stimulation
+
+226
+00:15:57,090 --> 00:16:02,670
+فبالتالي بيصير عندي مشكلة في مستوى الهرمونات
+
+227
+00:16:02,670 --> 00:16:07,390
+treatment that taking hormone as injection or a
+
+228
+00:16:07,390 --> 00:16:12,230
+drug to stimulation the ovary and increase the
+
+229
+00:16:12,230 --> 00:16:18,750
+number of oocyte it will be evaluated ovulated it
+
+230
+00:16:18,750 --> 00:16:23,890
+will be ovulated but there are rare cases of OHSS
+
+231
+00:16:23,890 --> 00:16:27,150
+occurring spontaneously يعني بوضع الطبيعي أن هذا
+
+232
+00:16:27,150 --> 00:16:30,910
+المرض أو هذه الحالة أو هذه الـ case اللي سميتها
+
+233
+00:16:30,910 --> 00:16:34,170
+Ovarian Hyperstimulation Syndrome ما بتحدث في شكل
+
+234
+00:16:34,170 --> 00:16:38,210
+تلقائي إلا في عدد قليل جدا لا يذكر معظم الحالات
+
+235
+00:16:38,210 --> 00:16:40,790
+اللي تم تأكيدها أنها Ovarian Hyperstimulation
+
+236
+00:16:40,790 --> 00:16:44,910
+Syndrome بتكون لسيدات خضعوا إلى الـ Ovarian
+
+237
+00:16:44,910 --> 00:16:50,260
+induction أو الـ Ovarian Stimulation طيب الـ OHSS
+
+238
+00:16:50,260 --> 00:16:52,620
+happened during fertility treatment using
+
+239
+00:16:52,620 --> 00:17:00,400
+medication you take by mouth such as Clomiphene
+
+240
+00:17:00,400 --> 00:17:04,000
+يعني بعض السيدات ممكن تكون ماخدة fertility
+
+241
+00:17:04,000 --> 00:17:10,920
+treatment عن طريق الـ mouth فممكن يظهر عندها زي
+
+242
+00:17:10,920 --> 00:17:14,640
+عفواً الـ Clomiphene فممكن يظهر عندها ما يعرف باسم
+
+243
+00:17:14,640 --> 00:17:20,440
+الـ OHSS الـ excessive dose للهرمونات التي تُعطى
+
+244
+00:17:20,440 --> 00:17:28,720
+بدون أي رقابة قد تؤدي إلى حدوث OHSS مما يصاحبه من
+
+245
+00:17:28,720 --> 00:17:34,180
+زيادة في حجم المبيض، تضخم في حجم المبيض، ظهور للـ
+
+246
+00:17:34,180 --> 00:17:37,720
+cyst حوالين المبيض، و ضغط لكمية كبيرة جدا من الـ
+
+247
+00:17:37,720 --> 00:17:43,600
+fluid في الـ intravascular space فبالتالي قسموا من
+
+248
+00:17:43,600 --> 00:17:48,470
+حيث الـ severity إلى moderate و severe قسموا من حيث
+
+249
+00:17:48,470 --> 00:17:52,890
+وقت الحدوث إلى Early و Late قسموا من حيث الأسباب
+
+250
+00:17:52,890 --> 00:17:59,790
+إلى spontaneous وحاجة بنتسموها heterogenic وهي
+
+251
+00:17:59,790 --> 00:18:03,930
+عبارة عن حالة مرضية تحدث بالفعل تناول السيدة
+
+252
+00:18:03,930 --> 00:18:08,150
+لهرمونات عن طريق الـ mouth أو عن طريق الـ injection
+
+253
+00:18:08,150 --> 00:18:17,960
+الـ Early OHSS تظهر بعد عملية الـ ovulation بعد الـ
+
+254
+00:18:17,960 --> 00:18:22,700
+ovulatory dose بتلات إلى سبع أيام of the HCG where
+
+255
+00:18:22,700 --> 00:18:27,260
+as الـ late من 12 إلى 17 يوم يعني وين اليوم اللي
+
+256
+00:18:27,260 --> 00:18:34,400
+تم إعطاء الزوجة الـ HCG ممكن يظهر الـ OHSS إذا ظهر من
+
+257
+00:18:34,400 --> 00:18:38,500
+اتنين إلى تلات أيام بعد الـ ovulation بيكون Early إذا 
+
+258
+00:18:38,500 --> 00:18:43,040
+ظهر بعد إثني عشر يوم بيكون Late مشكلة أكثر لـ Ovarian
+
+259
+00:18:43,040 --> 00:18:48,540
+Hyperstimulation Syndrome هي iatrogenic بسبب إعطاء
+
+260
+00:18:48,540 --> 00:18:54,100
+الـ Gonadotropin الهرمون كمية قليلة جدا تحدث بفعل 
+
+261
+00:18:54,100 --> 00:18:58,900
+spontaneous قد تكون بفعل الـ mutation أثرت على الـ
+
+262
+00:18:58,900 --> 00:19:02,500
+receptor المسؤول عن استقبال الـ FSH والـ LH مما
+
+263
+00:19:02,500 --> 00:19:06,580
+أدى إلى حدوث الـ Ovarian Hyperstimulation Syndrome
+
+264
+00:19:06,580 --> 00:19:11,590
+الذي يؤثر على الـ pregnancy بشكل عام Ovarian
+
+265
+00:19:11,590 --> 00:19:14,550
+Hyperstimulation Syndrome, we can classify it
+
+266
+00:19:14,550 --> 00:19:17,750
+according to the severity into mild, moderate,
+
+267
+00:19:18,310 --> 00:19:23,070
+severe وفي بعض الأحيان بيسموه critical grade الـ
+
+268
+00:19:23,070 --> 00:19:27,270
+mild الـ ovary إذا أنا قسته عن طريق الـ ultrasound
+
+269
+00:19:27,270 --> 00:19:31,490
+هيكون أقل من 8 سم وفي الغالب بيكون عندها Mild الـ
+
+270
+00:19:31,490 --> 00:19:35,630
+symptoms اللي علاقة بالأبدومير الـ moderate إذا أنا
+
+271
+00:19:35,630 --> 00:19:39,030
+قست الـ ovary من خلال الـ ultrasound هيكون من 8 إلى
+
+272
+00:19:39,030 --> 00:19:47,730
+12 الـ fluid حوالين الـ abdominal البريتونيوم في
+
+273
+00:19:47,730 --> 00:19:51,610
+الـ severe هيكون الـ diameter بتاع الـ ovary أكثر من
+
+274
+00:19:51,610 --> 00:19:57,010
+12 سم وهذه حالة مقلقة إلى حد ما بالنسبة لـ الـ
+
+275
+00:19:57,010 --> 00:19:59,890
+mild والـ moderate الـ symptoms بيصير عندها
+
+276
+00:19:59,890 --> 00:20:04,550
+abdominal pain السيدة بيصير عندها زيادة في محيط
+
+277
+00:20:04,550 --> 00:20:09,190
+الخصر وعندها انتفاخات بيصير عندها adenasia و
+
+278
+00:20:09,190 --> 00:20:12,880
+vomiting diarrhea بيصير في عندها تصلب في منطقة الـ
+
+279
+00:20:12,880 --> 00:20:16,000
+ovary أيضًا الـ severe Ovarian Hyperstimulation
+
+280
+00:20:16,000 --> 00:20:19,620
+Syndrome بيصير في عندها rapid weight بتكتسب 
+
+281
+00:20:19,620 --> 00:20:25,500
+increasing in the body weight بشكل سريع جدًا بمعدل
+
+282
+00:20:25,500 --> 00:20:29,620
+1 kilogram لكل 24 ساعة بصير عندها abdominal pain
+
+283
+00:20:29,620 --> 00:20:32,520
+بصير عندها nasal vomiting very severe بصير عندها
+
+284
+00:20:32,520 --> 00:20:34,760
+decrease في ال urination بصير في عندها blood 
+
+285
+00:20:34,760 --> 00:20:38,940
+clotting بصير في عندها problem in the breathing
+
+286
+00:20:38,940 --> 00:20:42,290
+short breathing بصير عندها أيضًا enlargement في
+
+287
+00:20:42,290 --> 00:20:47,890
+منطقة الـ Thigh ومنطقة الـ Abdomen طب إيش العامل
+
+288
+00:20:47,890 --> 00:20:50,310
+اللي ممكن يتزيد من فرصة حدوث الـ Ovarian
+
+289
+00:20:50,310 --> 00:20:54,370
+Hyperstimulation Syndrome؟ أول عامل وأختارهم هو
+
+290
+00:20:54,370 --> 00:20:57,630
+الـ Polycystic Ovarian Syndrome الـ Polycystic
+
+291
+00:20:57,630 --> 00:21:02,030
+Ovarian Syndrome حالة مرضية بتعاني منها بعض
+
+292
+00:21:02,030 --> 00:21:06,910
+السيدات اللي لهم أصلاً history خاص بالـ Polycystic
+
+293
+00:21:06,910 --> 00:21:11,970
+Ovarian Syndrome مشكلة polycystic ovarian syndrome
+
+294
+00:21:11,970 --> 00:21:16,730
+هو بيظهر سيست في منطقة الـ ovary مما يؤدي إلى
+
+295
+00:21:16,730 --> 00:21:19,910
+خربطة في ال menstrual cycle بيبقى ال menstrual
+
+296
+00:21:19,910 --> 00:21:24,810
+cycle مش منتظمة طبعا هذا بيمنع الإنجاب أو يؤخر
+
+297
+00:21:24,810 --> 00:21:28,690
+الإنجاب ولكن لا يمنعه بشكل مطلق ممكن لو تم إزالة
+
+298
+00:21:28,690 --> 00:21:35,460
+السيست مع إلاجات ترجع السيدة تنجب بشكل طبيعي ممكن
+
+299
+00:21:35,460 --> 00:21:39,880
+ال risk factor يزيد لو تم اعطاء الزوجة او السيدة
+
+300
+00:21:39,880 --> 00:21:43,780
+دوز عالي من ال human Chorionic Gonadotropin خلال ال IVF
+
+301
+00:21:43,780 --> 00:21:50,260
+cycle أو اعطت large number of follicles ممكن بعضهم
+
+302
+00:21:50,260 --> 00:21:57,840
+يكون free عمرها أقل من 35 ال body weight very low
+
+303
+00:21:57,840 --> 00:22:03,440
+أو عندها في تاريخ الطب إصابات سابقة بال ovarian
+
+304
+00:22:03,440 --> 00:22:08,780
+hyper stimulation So what is the complication؟
+
+305
+00:22:08,780 --> 00:22:11,760
+الكمبليكيشن لهذه الحالة المرضية أول حاجة بتسميها
+
+306
+00:22:11,760 --> 00:22:16,320
+من الكمبليكيشن وجود imbalance في ال electrolyte
+
+307
+00:22:16,320 --> 00:22:20,300
+وذلك بسبب severe fluid will be shifted out of the
+
+308
+00:22:20,300 --> 00:22:22,060
+blood vessels may be effected on the blood
+
+309
+00:22:22,060 --> 00:22:26,120
+pressure أنه بيصير في shifting كمية كبيرة جدا من
+
+310
+00:22:26,120 --> 00:22:31,000
+السوائل من الدموية إلى الفراغ ما بين الخلايا هذا
+
+311
+00:22:31,000 --> 00:22:36,020
+يجعل لدي الـ Electrolyte imbalance في عندي status
+
+312
+00:22:36,020 --> 00:22:41,620
+of thrombotic abnormality وذلك بفعل عند وجود خلل
+
+313
+00:22:41,620 --> 00:22:45,980
+في الأستروجين لأن الأستروجين بيلعب دور مهم جدا as
+
+314
+00:22:45,980 --> 00:22:51,060
+a pro-coagulant hormone one may develop
+
+315
+00:22:51,060 --> 00:22:55,460
+hemoconcentration and cause abnormal blood clot in
+
+316
+00:22:55,460 --> 00:23:01,660
+large vessels usually lower limb في عندي مشكلة في
+
+317
+00:23:01,660 --> 00:23:07,020
+مستوى الأستروجين في السيدات اللى عندهم ovarian
+
+318
+00:23:07,020 --> 00:23:11,240
+hyperstimulation syndrome فبصير عندهم مشاكل في ال
+
+319
+00:23:11,240 --> 00:23:14,200
+coagulation cascade أو ال coagulation status أو ال
+
+320
+00:23:14,200 --> 00:23:18,640
+thrombotic status بفعل وجود خلل في الأستروجين لأن
+
+321
+00:23:18,640 --> 00:23:21,920
+الأستروجين في الأصل بيشتغل ك pro-coagulant hormone
+
+322
+00:23:21,920 --> 00:23:25,320
+فممكن يصير عندها من أحد ال complications kidney
+
+323
+00:23:25,320 --> 00:23:32,200
+failure مشاكل في ال kidney التوقعات في الـ Ovary يصير
+
+324
+00:23:32,200 --> 00:23:34,780
+في عندي rupture للسست الموجودة مما يؤدي إلى حدوث
+
+325
+00:23:34,780 --> 00:23:38,180
+ال bleeding ممكن يصير عندي مشكلة في ال breathing
+
+326
+00:23:38,180 --> 00:23:41,540
+ما تقدر تاخد نفسها بفعل كمية كبيرة جدا من ال fluid
+
+327
+00:23:41,540 --> 00:23:45,420
+اللي تسربت فتضغط على الرئتين ممكن يصير عندها
+
+328
+00:23:45,420 --> 00:23:48,880
+abortion, miscarriage ممكن يؤدي إلى ال death في
+
+329
+00:23:48,880 --> 00:23:53,300
+بعض الحالات سجلات سيدات بسبب النزيف الداخلي العصبي
+
+330
+00:23:53,300 --> 00:23:56,700
+مثلًا بسبب كمية ال fluid الموجودة على الرئتين بفعل
+
+331
+00:23:56,700 --> 00:23:59,580
+أحد ال complications في فئة ال bleeding هذه كلها
+
+332
+00:23:59,580 --> 00:24:03,320
+إذا كانت مافي monitoring مافي treatment قد تؤدي
+
+333
+00:24:03,320 --> 00:24:09,100
+إلى الوفاة فبالتالي كيف يمكن تجنب هذا الأمر ال
+
+334
+00:24:09,100 --> 00:24:14,080
+prevention من خلال أول حاجة أن أعمل evaluation و
+
+335
+00:24:14,080 --> 00:24:19,520
+adjusting لـ ال medication الدكتور و الطبيب المعالج 
+
+336
+00:24:19,770 --> 00:24:23,790
+لازم يتأكد من كمية من الجرعة وكيفية يعطيها ويعطيها 
+
+337
+00:24:23,790 --> 00:24:28,110
+بالشكل السليم الجرعة المناسبة تحدد من خلال عدد
+
+338
+00:24:28,110 --> 00:24:33,690
+الـ follicles التي تؤهل للنضوج كيف هي استجابة المبيض
+
+339
+00:24:33,690 --> 00:24:38,510
+للـ analogues التي تُعطى أو للهرمونات التي تُعطى 
+
+340
+00:24:38,510 --> 00:24:42,810
+أيضًا، some medications seem to reduce the risk of
+
+341
+00:24:42,810 --> 00:24:45,510
+ovarian hyperstimulation syndrome without
+
+342
+00:24:45,510 --> 00:24:49,710
+affecting the odds of pregnancy بعض الأحيان فيه
+
+343
+00:24:49,710 --> 00:24:54,850
+medication تُوصف تؤدي إلى خفض معدل أو risk factor
+
+344
+00:24:54,850 --> 00:24:58,030
+لهذه الحالة أو لهذا المرض ولكن ما بتأثر على ال
+
+345
+00:24:58,030 --> 00:25:01,790
+fertility و ما بتأثر على ال pregnancy أيضًا بياضف 
+
+346
+00:25:01,790 --> 00:25:06,610
+إلى ذلك من أهم الأمور التثبيت أو الهبوط إيش يعني
+
+347
+00:25:06,610 --> 00:25:10,890
+التثبيت أو الهبوط يعني أنا ممكن أقلل الجرعة ببساطة
+
+348
+00:25:10,890 --> 00:25:14,870
+جدا ما أخليها على جرعة واحدة if your estrogen for
+
+349
+00:25:14,870 --> 00:25:19,170
+example level is very high or you have a large
+
+350
+00:25:19,170 --> 00:25:21,950
+number of developing follicle your doctor may
+
+351
+00:25:21,950 --> 00:25:25,630
+have you stop injectable medication and wait a few
+
+352
+00:25:25,630 --> 00:25:29,870
+days يعني والله خمس أيام بيعطيها جرعة معينة من
+
+353
+00:25:29,870 --> 00:25:35,310
+الهرمونات لقى فجأة الاستروجين عالي جدا عمل ال
+
+354
+00:25:35,310 --> 00:25:38,710
+ultrasound كمية كبيرة جدا أو عدد لابأس فيه من ال
+
+355
+00:25:38,710 --> 00:25:43,650
+follicles قريب إنه ينضج يصير mature ما في عندي مشكلة 
+
+356
+00:25:43,650 --> 00:25:47,330
+لو وقفت عملية ال injection يوم يومين ثلاثة أربعة
+
+357
+00:25:47,330 --> 00:25:52,210
+حتى أؤخر عملية الـ maturation وما أخلي الزوجة أو 
+
+358
+00:25:52,210 --> 00:25:54,390
+السيدة تدخل في الـ ovarian hyperstimulation
+
+359
+00:25:54,390 --> 00:25:59,310
+syndrome بعد كده أرجع أعطيها الهرمونات مرة جديدة
+
+360
+00:25:59,310 --> 00:26:02,270
+لاكمال عملية ال ovarian أو ال follicular
+
+361
+00:26:02,270 --> 00:26:06,270
+maturation هذا ما في عندها مشكلة أنه اهبط و اخفض
+
+362
+00:26:06,270 --> 00:26:10,450
+الجرعة ما في مشكلة أيضًا حاجة مهمة جدا أن نعمل
+
+363
+00:26:10,450 --> 00:26:14,370
+cancel ال cycle cancellation أو canceling cycle مش
+
+364
+00:26:14,370 --> 00:26:18,190
+غلط إنه أنا لو كان معظم المعايير و المؤشرات
+
+365
+00:26:18,190 --> 00:26:20,870
+بتقولوا إن هذه الزوجة أو هذه السيدة هتروح لل
+
+366
+00:26:20,870 --> 00:26:24,730
+ovarian hyper stimulation syndrome مش غلط إن أوقف
+
+367
+00:26:24,730 --> 00:26:28,130
+ال cycle و أعمل dropping و أعمل canceling لل cycle
+
+368
+00:26:28,130 --> 00:26:32,450
+و أريح السيدة شهر شهرين ثلاثة و ارجع من أول جديد
+
+369
+00:26:32,450 --> 00:26:42,090
+في cycle جديدة مش غلط يعني خسارة قريبة أفضل من ما
+
+370
+00:26:42,090 --> 00:26:48,720
+أُكسب بعيد مهم جدا أن أنا أوقف الـ cycle أوقف ال
+
+371
+00:26:48,720 --> 00:26:51,760
+stimulation أوقف ال induction في الوقت المناسب
+
+372
+00:26:51,760 --> 00:26:57,260
+holding HCG used to be the most common method used
+
+373
+00:26:57,260 --> 00:27:00,240
+to prevent ovarian hyperstimulation syndrome in
+
+374
+00:27:00,240 --> 00:27:03,480
+patients predicted to be at high risk for
+
+375
+00:27:03,480 --> 00:27:05,460
+development or to development of ovarian
+
+376
+00:27:05,460 --> 00:27:09,480
+hyperstimulation syndrome بمعنى آخر إنه حكوا 
+
+377
+00:27:09,870 --> 00:27:16,650
+العلماء أن أي سيدة مستوى الاستروجين بيكون أكبر من
+
+378
+00:27:16,650 --> 00:27:23,770
+أو يساوي 4000 Pg per ml هذه السيدة مؤهلة للدخول في
+
+379
+00:27:23,770 --> 00:27:27,190
+الـ Ovarian Hyper Stimulation Syndrome فبالتالي قدامك 
+
+380
+00:27:27,190 --> 00:27:31,110
+حال من الاثنين يا تخفض الدوز أو توقفها مؤقت أو
+
+381
+00:27:31,110 --> 00:27:36,910
+توقف عملية ال induction equal or more important
+
+382
+00:27:36,910 --> 00:27:40,700
+and critical for cancelling cycle than estradiol
+
+383
+00:27:40,700 --> 00:27:46,100
+level are the number of follicles أربعة ثمانية
+
+384
+00:27:46,100 --> 00:27:49,820
+لعشرة ملي متر follicles that maybe have acquired
+
+385
+00:27:49,820 --> 00:27:55,740
+ال LH receptors  خد بجانب ال E2 جدش عندي عدد ال
+
+386
+00:27:55,740 --> 00:27:58,620
+follicles اللي وصلت ل ثمانية لعشرة ملي متر يعني
+
+387
+00:27:58,620 --> 00:28:02,740
+قريب من 4 ملي متر و تصل ل ال mature ممكن يكون 
+
+388
+00:28:02,740 --> 00:28:06,500
+عندي ما تقدر تصل ل ال mature فبالتالي هأعطيها دوز 
+
+389
+00:28:06,500 --> 00:28:10,910
+عالية أستمر في عطاء الدوز يعني كأني بأجبر المبيض إنه
+
+390
+00:28:10,910 --> 00:28:14,210
+ينضج لأكبر عدد من الـ follicles التي تحتوي على
+
+391
+00:28:14,210 --> 00:28:18,270
+البويضات الناضجة وهذا مشكلة بيقع فيها بعض الأطباء 
+
+392
+00:28:18,270 --> 00:28:21,910
+إنه ما بياخدوا القرار المناسب في الوقت المناسب من
+
+393
+00:28:21,910 --> 00:28:27,090
+أجل إيقاف الدورة أو إنقاص الدوز أو إيقاف الدوز ولو
+
+394
+00:28:27,090 --> 00:28:31,430
+بشكل مؤقت هذه الأمور المتعلقة بالـ ovarian
+
+395
+00:28:31,430 --> 00:28:36,320
+hyperstimulation syndrome بالإضافة إلىالكمبليكيشن 
+
+396
+00:28:36,320 --> 00:28:40,300
+ال risk factor وكيف ممكن نعمل presentation أو نعمل
+
+397
+00:28:40,300 --> 00:28:44,760
+avoiding لل ovarian hyperstimulation syndrome سوف
+
+398
+00:28:44,760 --> 00:28:48,360
+نتوقف عند هذا الكم من المعلومات في هذه المحاضرة
+
+399
+00:28:48,360 --> 00:28:52,340
+على أمل أن نلتقي في محاضرات قادمة إن شاء الله دوم
+
+400
+00:28:52,340 --> 00:28:53,540
+دوم في حفظ الله
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/VNoCop9C_V4_raw.json b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/VNoCop9C_V4_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..0c545cc98fa14409f1e1b51124033d9be0fd6e04
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/VNoCop9C_V4_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2780, "start": 0.0, "end": 27.8, "text": "بسم الله الرحمن الرحيم والصلاة والسلام على أشرف المرسلين سيدنا محمد وعلى آله وصحبه أجمعين طلبنا الأعزاء نرجو من الله الكريم أن تكونوا بصحة جيدة وبكل خيارة اليوم سوف نستكمل ما بدأنا فيه من stimulation protocol what is the difference between agonist and antagonist what is the difference between long short ultra short protocol", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 16070, 9381, 15040, 3660, 16070, 3794, 37440, 15844, 5551, 8592, 28480, 9673, 2288, 3794, 1211, 9957, 8608, 25708, 8315, 3714, 35571, 3215, 4032, 3615, 23942, 19753, 43761, 4032, 9381, 5016, 3555, 3224, 5551, 7435, 2304, 3615, 9957, 23032, 46152, 8315, 16247, 3615, 11622, 16606, 8717, 47341, 2407, 9154, 21984, 33251, 16572, 2304, 14739, 6055, 30544, 14407, 4724, 9381, 5016, 3660, 10874, 25708, 3660, 46599, 28820, 16490, 1829, 9640, 3660, 45595, 20498, 8608, 38688, 8717, 14851, 24793, 1211, 19446, 47525, 10721, 8315, 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"text": "ما بيحفظ الـ anterior loop و الـ pituitary gland لأ بيعملها blocking بشكل مباشر وبشكل سريع من خلال ارتباط مادة معينة مع الـ receptor اللي لها علاقة بالـ gonadotropin-releasing hormone receptor مما يؤدي إلى امتناع الـ loop الخاصة بالـ pituitary gland الـ anterior loop من إفراز الـ FSH والـ LH So in the antagonist protocol", "tokens": [15042, 4724, 1829, 5016, 5172, 19913, 2423, 39184, 22272, 6367, 4032, 2423, 39184, 10147, 1983, 822, 43284, 5296, 10721, 4724, 1829, 25957, 1211, 11296, 17776, 4724, 8592, 28820, 3714, 3555, 33599, 2288, 46599, 8592, 28820, 8608, 16572, 3615, 9154, 16490, 1211, 6027, 1975, 43500, 3555, 41193, 3714, 18513, 3660, 20449, 9957, 3660, 20449, 2423, 39184, 32264, 13672, 1829, 5296, 11296, 11203, 995, 28671, 20666, 39184, 26307, 345, 310, 1513, 259, 12, 265, 306, 3349, 24211, 32264, 3714, 15042, 7251, 33604, 16254, 30731, 1975, 2304, 2655, 8315, 3615, 2423, 39184, 6367, 33962, 33546, 3660, 20666, 39184, 10147, 1983, 822, 43284, 2423, 39184, 22272, 6367, 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{"start": 837.36, "end": 837.5, "word": " او", "probability": 0.7288818359375}, {"start": 837.5, "end": 837.62, "word": " ال", "probability": 0.93603515625}, {"start": 837.62, "end": 837.88, "word": " injection", "probability": 0.5576171875}, {"start": 837.88, "end": 838.52, "word": " الأخرى", "probability": 0.93310546875}, {"start": 838.52, "end": 838.76, "word": " و", "probability": 0.7978515625}, {"start": 838.76, "end": 839.14, "word": " بعطي", "probability": 0.72113037109375}, {"start": 839.14, "end": 839.62, "word": " injection", "probability": 0.84375}, {"start": 839.62, "end": 840.32, "word": " واحدة", "probability": 0.9514973958333334}, {"start": 840.32, "end": 841.22, "word": " بهرمون", "probability": 0.77109375}, {"start": 841.22, "end": 841.78, "word": " اسمه", "probability": 0.9554036458333334}, {"start": 841.78, "end": 842.74, "word": " HCG", "probability": 0.7509765625}, {"start": 842.74, "end": 843.28, "word": " hormone", "probability": 0.677734375}, {"start": 843.28, 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"start": 868.17, "end": 893.21, "text": "تحدث بعد 36 إلى 40 ساعة من ال injection يعني لو أنا أعطيت الزوجة ال HCG الساعة 4 العصر عيد 36 ساعة إلى 40 ساعة خلال الفترة هذه لازم يصير عندي ovulation therefore it is standard that the HCG injection is administrated 36 hours before the schedule egg collected such that", "tokens": [2655, 24401, 12984, 39182, 8652, 30731, 3356, 8608, 995, 27884, 9154, 2423, 22873, 37495, 22653, 45164, 41850, 5551, 3615, 9566, 36081, 6024, 110, 29245, 3660, 2423, 30440, 38, 21136, 995, 27884, 1017, 18863, 9381, 2288, 6225, 25708, 8652, 8608, 995, 27884, 30731, 3356, 8608, 995, 27884, 16490, 1211, 6027, 27188, 2655, 25720, 29538, 5296, 31377, 2304, 7251, 9381, 13546, 18871, 16254, 14187, 2776, 4412, 309, 307, 3832, 300, 264, 30440, 38, 22873, 307, 4968, 5468, 8652, 2496, 949, 264, 7567, 3777, 11087, 1270, 300], "avg_logprob": -0.16277574020273544, "compression_ratio": 1.4896265560165975, "no_speech_prob": 7.152557373046875e-07, "words": [{"start": 868.17, "end": 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الأحيان بيسموه critical grade الـ mild الـ ovary إذا أنا قسته عن طريق ال ultrasound هيكون أقل من 8 cm و في الغالب بيكون عندها mild ال symptoms اللي علاقة بالأبدومير المoderate إذا أنا قست ال ovary من خلال ال ultrasound هيكون من 8 إلى 12", "tokens": [36, 2757, 5501, 9848, 372, 332, 2776, 19371, 11, 321, 393, 33872, 309, 4650, 281, 264, 35179, 666, 15154, 11, 18174, 11, 8922, 4032, 41185, 45030, 11242, 16247, 5016, 1829, 7649, 4724, 1829, 38251, 2407, 3224, 4924, 7204, 2423, 39184, 15154, 2423, 39184, 14187, 822, 11933, 15730, 41850, 12174, 14851, 3224, 18871, 23032, 16572, 4587, 2423, 40895, 8032, 1829, 30544, 5551, 4587, 1211, 9154, 1649, 14668, 4032, 8978, 6024, 118, 6027, 3555, 4724, 1829, 30544, 43242, 11296, 15154, 2423, 8332, 13672, 1829, 11203, 995, 28671, 20666, 10721, 3555, 3215, 20498, 13546, 9673, 19866, 473, 11933, 15730, 41850, 12174, 14851, 2423, 14187, 822, 9154, 16490, 1211, 6027, 2423, 40895, 8032, 1829, 30544, 9154, 1649, 30731, 2272], "avg_logprob": 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1172.39, "word": " علاقة", "probability": 0.8929036458333334}, {"start": 1172.39, "end": 1173.01, "word": " بالأبدومير", "probability": 0.63494873046875}, {"start": 1173.01, "end": 1174.69, "word": " المoderate", "probability": 0.6150309244791666}, {"start": 1174.69, "end": 1175.45, "word": " إذا", "probability": 0.952880859375}, {"start": 1175.45, "end": 1175.63, "word": " أنا", "probability": 0.9228515625}, {"start": 1175.63, "end": 1175.85, "word": " قست", "probability": 0.962890625}, {"start": 1175.85, "end": 1175.99, "word": " ال", "probability": 0.9306640625}, {"start": 1175.99, "end": 1176.41, "word": " ovary", "probability": 0.8837890625}, {"start": 1176.41, "end": 1177.41, "word": " من", "probability": 0.98828125}, {"start": 1177.41, "end": 1177.67, "word": " خلال", "probability": 0.9568684895833334}, {"start": 1177.67, "end": 1177.79, "word": " ال", "probability": 0.984375}, {"start": 1177.79, "end": 1178.13, "word": " ultrasound", "probability": 0.9287109375}, {"start": 1178.13, "end": 1178.53, "word": " هيكون", "probability": 0.7096354166666666}, {"start": 1178.53, "end": 1178.65, "word": " من", "probability": 0.9775390625}, {"start": 1178.65, "end": 1178.91, "word": " 8", "probability": 0.97412109375}, {"start": 1178.91, "end": 1179.03, "word": " إلى", "probability": 0.290283203125}, {"start": 1179.03, "end": 1179.35, "word": " 12", "probability": 0.95654296875}], "temperature": 1.0}, {"id": 43, "seek": 121029, "start": 1181.05, "end": 1210.29, "text": "الـ fluid حوالين الـ abdominal البريتونيوم في الـ severe هيكون ال diameter بتاع ال ovary أكتر من 12 صنطي و هذه حالة مقلقة إلى حد ما بالنسبة ل ال mild و ال moderate ال symptoms بصير عندها abdominal pain السيدة بصير عندها زيادة في محيط الخسر و عندها انتفاخات بصير عندها adenasia و vomiting دياريا", "tokens": [6027, 39184, 9113, 11331, 2407, 6027, 9957, 2423, 39184, 38701, 2423, 26890, 36081, 11536, 1829, 20498, 8978, 2423, 39184, 8922, 39896, 30544, 2423, 14196, 39894, 45761, 2423, 14187, 822, 5551, 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"word": " هعضيها", "probability": 0.86103515625}, {"start": 1686.2, "end": 1686.5, "word": " دوز", "probability": 0.7233072916666666}, {"start": 1686.5, "end": 1686.9, "word": " عالي", "probability": 0.9091796875}], "temperature": 1.0}, {"id": 61, "seek": 171419, "start": 1687.25, "end": 1714.19, "text": "هستمر في عضاء الدوز يعني كأني بجبر المبيض انه ينضج لأكبر عدد من الـ follicle التي تحتوي على البويضات الناضجة وهذا مشكلة بيقع فيها بعض الأطباء انه ما بياخدوا القرار المناسب في الوقت المناسب من أجل إيقاف الدورة أو انقاص الدوز أو إيقاف الدوز ولو بشكل مؤقت هذه الأمور المتعلقة بالـ ovarian hyperstimulation syndrome بالإضافة إلى", "tokens": [3224, 14851, 29973, 8978, 6225, 11242, 16606, 32748, 2407, 11622, 37495, 22653, 9122, 33456, 1829, 4724, 7435, 26890, 9673, 21292, 11242, 16472, 3224, 7251, 1863, 11242, 7435, 5296, 10721, 4117, 26890, 6225, 3215, 3215, 9154, 2423, 39184, 25483, 3520, 38392, 6055, 33753, 45865, 15844, 29739, 45865, 11242, 9307, 28239, 46958, 7435, 3660, 37037, 15730, 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{"start": 1688.25, "end": 1688.41, "word": " الدوز", "probability": 0.8772786458333334}, {"start": 1688.41, "end": 1688.69, "word": " يعني", "probability": 0.69921875}, {"start": 1688.69, "end": 1688.99, "word": " كأني", "probability": 0.6780598958333334}, {"start": 1688.99, "end": 1689.51, "word": " بجبر", "probability": 0.9583333333333334}, {"start": 1689.51, "end": 1690.13, "word": " المبيض", "probability": 0.96044921875}, {"start": 1690.13, "end": 1690.91, "word": " انه", "probability": 0.6396484375}, {"start": 1690.91, "end": 1691.31, "word": " ينضج", "probability": 0.9195556640625}, {"start": 1691.31, "end": 1691.81, "word": " لأكبر", "probability": 0.917724609375}, {"start": 1691.81, "end": 1692.11, "word": " عدد", "probability": 0.98974609375}, {"start": 1692.11, "end": 1692.29, "word": " من", "probability": 0.9873046875}, {"start": 1692.29, "end": 1692.47, "word": " الـ", "probability": 0.43450927734375}, {"start": 1692.47, "end": 1692.87, "word": " follicle", "probability": 0.6800537109375}, {"start": 1692.87, "end": 1693.47, "word": " التي", "probability": 0.68017578125}, {"start": 1693.47, "end": 1694.03, "word": " تحتوي", "probability": 0.94140625}, {"start": 1694.03, "end": 1694.21, "word": " على", "probability": 0.8564453125}, {"start": 1694.21, "end": 1694.75, "word": " البويضات", "probability": 0.8470458984375}, {"start": 1694.75, "end": 1695.35, "word": " الناضجة", "probability": 0.916015625}, {"start": 1695.35, "end": 1695.91, "word": " وهذا", "probability": 0.711181640625}, {"start": 1695.91, "end": 1696.57, "word": " مشكلة", "probability": 0.9788411458333334}, {"start": 1696.57, "end": 1697.09, "word": " بيقع", "probability": 0.8367919921875}, {"start": 1697.09, "end": 1697.33, "word": " فيها", "probability": 0.969970703125}, {"start": 1697.33, "end": 1697.63, "word": " بعض", "probability": 0.936279296875}, {"start": 1697.63, "end": 1698.27, "word": " الأطباء", "probability": 0.9761962890625}, {"start": 1698.27, "end": 1698.89, "word": " انه", 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"word": " أو", "probability": 0.7978515625}, {"start": 1703.67, "end": 1705.33, "word": " انقاص", "probability": 0.6661783854166666}, {"start": 1705.33, "end": 1705.87, "word": " الدوز", "probability": 0.9246419270833334}, {"start": 1705.87, "end": 1706.07, "word": " أو", "probability": 0.72412109375}, {"start": 1706.07, "end": 1706.39, "word": " إيقاف", "probability": 0.9873046875}, {"start": 1706.39, "end": 1706.71, "word": " الدوز", "probability": 0.9840494791666666}, {"start": 1706.71, "end": 1707.09, "word": " ولو", "probability": 0.77294921875}, {"start": 1707.09, "end": 1707.77, "word": " بشكل", "probability": 0.9923502604166666}, {"start": 1707.77, "end": 1708.25, "word": " مؤقت", "probability": 0.8439127604166666}, {"start": 1708.25, "end": 1708.99, "word": " هذه", "probability": 0.57177734375}, {"start": 1708.99, "end": 1710.21, "word": " الأمور", "probability": 0.9803059895833334}, {"start": 1710.21, "end": 1710.81, "word": " المتعلقة", "probability": 0.9857177734375}, {"start": 1710.81, "end": 1711.01, "word": " بالـ", "probability": 0.7042236328125}, {"start": 1711.01, "end": 1711.43, "word": " ovarian", "probability": 0.760498046875}, {"start": 1711.43, "end": 1712.21, "word": " hyperstimulation", "probability": 0.8846435546875}, {"start": 1712.21, "end": 1712.75, "word": " syndrome", "probability": 0.9462890625}, {"start": 1712.75, "end": 1713.97, "word": " بالإضافة", "probability": 0.95576171875}, {"start": 1713.97, "end": 1714.19, "word": " إلى", "probability": 0.90625}], "temperature": 1.0}, {"id": 62, "seek": 173354, "start": 1715.5, "end": 1733.54, "text": "الكمبليكيشن ال risk factor وكيف ممكن نعمل presentation أو نعمل avoiding لل ovarian hyperstimulation syndrome سوف نتوقف عند هذا الكام من المعلومات في هذه المحاضرة على أمل أن نلتقي في محاضرات قادمة ان شاء الله دوم دوم في حفظ الله", "tokens": [6027, 24793, 3555, 20292, 4117, 1829, 8592, 1863, 2423, 3148, 5952, 4032, 4117, 33911, 3714, 43020, 8717, 25957, 1211, 5860, 34051, 8717, 25957, 1211, 20220, 24976, 277, 8517, 952, 9848, 372, 332, 2776, 19371, 8608, 38688, 8717, 2655, 30543, 5172, 43242, 23758, 33251, 10943, 9154, 9673, 30241, 20498, 9307, 8978, 29538, 9673, 5016, 46958, 25720, 15844, 5551, 42213, 14739, 8717, 1211, 2655, 38436, 8978, 3714, 5016, 46958, 2288, 9307, 12174, 18513, 46007, 16472, 13412, 16606, 21984, 11778, 20498, 11778, 20498, 8978, 11331, 5172, 19913, 21984], "avg_logprob": -0.2107558087554089, "compression_ratio": 1.5663716814159292, "no_speech_prob": 2.086162567138672e-06, "words": [{"start": 1715.5, "end": 1716.32, "word": "الكمبليكيشن", "probability": 0.68939208984375}, {"start": 1716.32, "end": 1716.6, "word": " ال", "probability": 0.3564453125}, {"start": 1716.6, "end": 1716.82, "word": " risk", "probability": 0.88427734375}, {"start": 1716.82, "end": 1717.34, "word": " factor", "probability": 0.83642578125}, {"start": 1717.34, "end": 1717.74, "word": " وكيف", "probability": 0.8095703125}, {"start": 1717.74, "end": 1718.04, "word": " ممكن", "probability": 0.854736328125}, {"start": 1718.04, "end": 1718.36, "word": " نعمل", "probability": 0.9894205729166666}, {"start": 1718.36, "end": 1719.02, "word": " presentation", "probability": 0.28369140625}, {"start": 1719.02, "end": 1719.86, "word": " أو", "probability": 0.81884765625}, {"start": 1719.86, "end": 1720.3, "word": " نعمل", "probability": 0.9573567708333334}, {"start": 1720.3, "end": 1720.96, "word": " avoiding", "probability": 0.70263671875}, {"start": 1720.96, "end": 1721.66, "word": " لل", "probability": 0.74951171875}, {"start": 1721.66, "end": 1722.22, "word": " ovarian", "probability": 0.7255045572916666}, {"start": 1722.22, "end": 1723.32, "word": " hyperstimulation", "probability": 0.697509765625}, {"start": 1723.32, "end": 1723.76, "word": " syndrome", "probability": 0.328857421875}, {"start": 1723.76, "end": 1724.76, "word": " سوف", "probability": 0.916748046875}, {"start": 1724.76, "end": 1725.36, "word": " نتوقف", "probability": 0.9921875}, {"start": 1725.36, "end": 1725.58, "word": " عند", "probability": 0.98974609375}, {"start": 1725.58, "end": 1725.88, "word": " هذا", "probability": 0.92431640625}, {"start": 1725.88, "end": 1726.34, "word": " الكام", "probability": 0.7001953125}, {"start": 1726.34, "end": 1726.76, "word": " من", "probability": 0.98046875}, {"start": 1726.76, "end": 1727.34, "word": " المعلومات", "probability": 0.9837646484375}, {"start": 1727.34, "end": 1727.48, "word": " في", "probability": 0.96240234375}, {"start": 1727.48, "end": 1727.74, "word": " هذه", "probability": 0.97119140625}, {"start": 1727.74, "end": 1728.36, "word": " المحاضرة", "probability": 0.99072265625}, {"start": 1728.36, "end": 1728.94, "word": " على", "probability": 0.84423828125}, {"start": 1728.94, "end": 1729.22, "word": " أمل", "probability": 0.91943359375}, {"start": 1729.22, "end": 1729.42, "word": " أن", "probability": 0.88623046875}, {"start": 1729.42, "end": 1729.8, "word": " نلتقي", "probability": 0.973388671875}, {"start": 1729.8, "end": 1729.98, "word": " في", "probability": 0.9755859375}, {"start": 1729.98, "end": 1730.52, "word": " محاضرات", "probability": 0.876708984375}, {"start": 1730.52, "end": 1730.96, "word": " قادمة", "probability": 0.9910481770833334}, {"start": 1730.96, "end": 1731.12, "word": " ان", "probability": 0.6318359375}, {"start": 1731.12, "end": 1731.36, "word": " شاء", "probability": 0.974609375}, {"start": 1731.36, "end": 1731.6, "word": " الله", "probability": 0.9404296875}, {"start": 1731.6, "end": 1732.34, "word": " دوم", "probability": 0.5931396484375}, {"start": 1732.34, "end": 1732.66, "word": " دوم", "probability": 0.9169921875}, {"start": 1732.66, "end": 1732.98, "word": " في", "probability": 0.89501953125}, {"start": 1732.98, "end": 1733.3, "word": " حفظ", "probability": 0.9943033854166666}, {"start": 1733.3, "end": 1733.54, "word": " الله", "probability": 0.6640625}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1735.9470625, "duration_after_vad": 1709.6703437499968}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/VNoCop9C_V4_raw.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/VNoCop9C_V4_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..98830f242512166d717ffac7934be8942eada165
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/VNoCop9C_V4_raw.srt
@@ -0,0 +1,1600 @@
+1
+00:00:00,000 --> 00:00:04,480
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:04,480 --> 00:00:09,580
+المرسلين سيدنا محمد وعلى آله وصحبه أجمعين طلبنا
+
+3
+00:00:09,580 --> 00:00:13,500
+الأعزاء نرجو من الله الكريم أن تكونوا بصحة جيدة
+
+4
+00:00:13,500 --> 00:00:18,480
+وبكل خيارة اليوم سوف نستكمل ما بدأنا فيه من
+
+5
+00:00:18,480 --> 00:00:22,340
+stimulation protocol what is the difference
+
+6
+00:00:22,340 --> 00:00:24,680
+between agonist and antagonist what is the
+
+7
+00:00:24,680 --> 00:00:27,800
+difference between long short ultra short protocol
+
+8
+00:00:28,380 --> 00:00:32,100
+تحدثنا في المحاضرة السابقة عن الـ Gonadotropin
+
+9
+00:00:32,100 --> 00:00:36,420
+-releasing hormone agonist protocol وقولنا أن هذا
+
+10
+00:00:36,420 --> 00:00:39,940
+ال protocol ينقسم إلى long و short و ultra short
+
+11
+00:00:39,940 --> 00:00:43,940
+بناء على ال duration time وحكينا إن هذه فكرته
+
+12
+00:00:43,940 --> 00:00:48,640
+ببساطة إن أنا بعطي السيدة gonadotropin-releasing
+
+13
+00:00:48,640 --> 00:00:52,560
+hormone analogues وظيفتها الأساسية بتعمل induction
+
+14
+00:00:52,560 --> 00:00:56,540
+و inducing و stimulationللـ anterior loop بقبطة
+
+15
+00:00:56,540 --> 00:01:01,320
+رجلان من أجل إفراز الناتيف FSH والقلاتش بعد فترة
+
+16
+00:01:01,320 --> 00:01:05,860
+زمانية باستمرار ال injection بيصير down regulation
+
+17
+00:01:05,860 --> 00:01:10,600
+للـ anterior loop مما يؤهلني إلى أطاق الركم بين
+
+18
+00:01:10,600 --> 00:01:16,660
+FSH بدوز معين ولفترة زمانية معينة تتعلق وتعتمد على
+
+19
+00:01:17,150 --> 00:01:22,110
+البطانة الرحم كيف وضعها ومدى استجابة المبيض عندما
+
+20
+00:01:22,110 --> 00:01:25,490
+تصل الفوليكل إلى أقل شيء تلاتة فوليكل وصلت إلى
+
+21
+00:01:25,490 --> 00:01:31,710
+الديامتر أكبر من أو يسوى 18 ملي ميتر ساعتها بعطي
+
+22
+00:01:31,710 --> 00:01:35,430
+ال injection اللي اسمه RHCG human corona
+
+23
+00:01:35,430 --> 00:01:39,130
+gonadotropin اللي بيعمل عمل القلش واللي بيساعد على
+
+24
+00:01:39,130 --> 00:01:43,230
+ال ovulation هذه فكرة ال gonadotropin releasing
+
+25
+00:01:43,230 --> 00:01:47,210
+hormone agonistاليوم نتكلم عن الـ Gonadotropin
+
+26
+00:01:47,210 --> 00:01:51,010
+Releasing Hormone Antagonist وكلهما يستخدم
+
+27
+00:01:51,010 --> 00:01:54,630
+Gonadotropin Releasing Hormone Analogues من أجل
+
+28
+00:01:54,630 --> 00:01:58,130
+تحفيز الـ anterior loop of pituitary gland الـ
+
+29
+00:01:58,130 --> 00:02:00,490
+Gonadotropin Releasing Hormone Antagonist
+
+30
+00:02:00,490 --> 00:02:03,350
+reversable binding to Gonadotropin Releasing
+
+31
+00:02:03,350 --> 00:02:07,210
+Hormone Receptor and prevent the releasing of FSH
+
+32
+00:02:07,210 --> 00:02:11,270
+and ALH يعني هذا الـ protocol اللي أنا بستخدمهما
+
+33
+00:02:11,270 --> 00:02:15,430
+بيحفظ الـ anterior loop و الـ pituitary gland لأ
+
+34
+00:02:15,430 --> 00:02:20,730
+بيعملها blocking بشكل مباشر وبشكل سريع من خلال
+
+35
+00:02:20,730 --> 00:02:25,430
+ارتباط مادة معينة مع الـ receptor اللي لها علاقة
+
+36
+00:02:25,430 --> 00:02:28,790
+بالـ gonadotropin-releasing hormone receptor مما
+
+37
+00:02:28,790 --> 00:02:32,810
+يؤدي إلى امتناع الـ loop الخاصة بالـ pituitary
+
+38
+00:02:32,810 --> 00:02:36,650
+gland الـ anterior loop من إفراز الـ FSH والـ LH
+
+39
+00:02:36,650 --> 00:02:41,500
+So in the antagonist protocolThere is no down
+
+40
+00:02:41,500 --> 00:02:44,900
+regulation.A gonadotropin-releasing hormone
+
+41
+00:02:44,900 --> 00:02:48,480
+antagonist bind and block the receptor of
+
+42
+00:02:48,480 --> 00:02:51,580
+gonadotropin-releasing hormone in pituitary gland
+
+43
+00:02:51,580 --> 00:02:58,800
+.This action led to immediately suppression of FSH
+
+44
+00:02:58,800 --> 00:03:03,380
+-FLH releasing يعني هنا الفرغ انه مافي اندي down
+
+45
+00:03:03,380 --> 00:03:06,720
+regulation يعني inducing بعدين reduction لأ في
+
+46
+00:03:06,720 --> 00:03:11,770
+اندي blocking بشكلمباشر من خلال إغلاق الـReceptor
+
+47
+00:03:11,770 --> 00:03:15,690
+الخاص بالـFSH والـLH.Gonadotropin-releasing
+
+48
+00:03:15,690 --> 00:03:19,730
+-hormone-antagonist have long half-life and high
+
+49
+00:03:19,730 --> 00:03:22,990
+affinity binding to the receptor of gonadotropin
+
+50
+00:03:22,990 --> 00:03:26,890
+-releasing-hormone but without activation them or
+
+51
+00:03:26,890 --> 00:03:29,630
+activating them صح إنه برتبط مع هذا الـReceptor
+
+52
+00:03:29,630 --> 00:03:34,610
+ولكن ما بحفظها بخلاف الـagonist.The gonadotropin
+
+53
+00:03:34,610 --> 00:03:37,790
+-releasing-hormone-antagonist immediately actionon
+
+54
+00:03:37,790 --> 00:03:42,290
+the prevention of LH surge and required a few
+
+55
+00:03:42,290 --> 00:03:46,990
+injections during the treatment cycle ما بحتاج إلى
+
+56
+00:03:46,990 --> 00:03:54,230
+حقن متعدد، لأ حقن بسيطة جدا، معدودة for this
+
+57
+00:03:54,230 --> 00:03:58,830
+protocol, gonadotropins are started on the cycle 2
+
+58
+00:03:58,830 --> 00:04:02,610
+in the cycle day number 2 يعني هذا ال protocol
+
+59
+00:04:02,610 --> 00:04:06,090
+بتميز أنه يبدأ في اليوم أو يمكن أن نبدأ فيه في
+
+60
+00:04:06,090 --> 00:04:10,110
+اليوم التاني من الدورةفمش محتاج ناخد من اليوم رقم
+
+61
+00:04:10,110 --> 00:04:14,490
+21 من الدورة السابقة ال advantage الخاصة فيه fewer
+
+62
+00:04:14,490 --> 00:04:19,270
+injections زي ما اتكلمنا قبل بشوية بيعمل
+
+63
+00:04:19,270 --> 00:04:24,270
+suppression ل ال FSH و ال LH بشكل سريع فبالتالي
+
+64
+00:04:24,270 --> 00:04:29,450
+بحتاج إلى injection و عدد قليل جدا بيعمل reduction
+
+65
+00:04:29,450 --> 00:04:33,390
+في فرصة حدوث الجنادو ال Oberian hyperstimulation
+
+66
+00:04:33,390 --> 00:04:38,760
+syndrome بعض الدراساتأو وجدت معلومات معينة ونتاج
+
+67
+00:04:38,760 --> 00:04:42,100
+معين على سبيل المثال وجدت أن الـ gonadotropin
+
+68
+00:04:42,100 --> 00:04:47,420
+-releasing hormone antagonist was effectiveness
+
+69
+00:04:47,420 --> 00:04:51,340
+as gonadotropin-releasing hormone analogues for
+
+70
+00:04:51,340 --> 00:04:56,420
+prevention of premature LH surge يعني وجدوا أن
+
+71
+00:04:56,420 --> 00:05:02,440
+كفائته ال effectiveness طبعته على منع ال premature
+
+72
+00:05:02,440 --> 00:05:10,650
+LH surgeأعلى من الـ agonist ايضا
+
+73
+00:05:10,650 --> 00:05:14,010
+احتمالية الحصول على ال pregnancy clinical
+
+74
+00:05:14,010 --> 00:05:18,970
+pregnancy وجدوا rate was shown to be lower than
+
+75
+00:05:18,970 --> 00:05:21,750
+gonadotropin releasing hormone antagonist group
+
+76
+00:05:21,750 --> 00:05:25,310
+وجدوا ان ال pregnancy rate عند استخدام ال
+
+77
+00:05:25,310 --> 00:05:28,950
+gonadotropin releasing hormone antagonist أقل ايضا
+
+78
+00:05:28,950 --> 00:05:32,530
+there is no difference in the life birth rateيعني
+
+79
+00:05:32,530 --> 00:05:37,250
+هذه تعتبر دراسات بعضهم قالت أن والله ال antagonist
+
+80
+00:05:37,250 --> 00:05:40,510
+أفضل من ال agonist بعضهم قال مافي اختلاف ما بينهم
+
+81
+00:05:40,510 --> 00:05:43,450
+و بعض قال لأ والله ال pregnancy rate as a clinical
+
+82
+00:05:43,450 --> 00:05:47,250
+pregnancy rate في ال antagonist أقل من ال agonist
+
+83
+00:05:47,250 --> 00:05:52,550
+فبتدالها دراسات تختلف بناء على طبيعة الدراسة في
+
+84
+00:05:52,550 --> 00:05:55,750
+ND2 protocol خاصة بال antagonist ال protocol الأول
+
+85
+00:05:55,750 --> 00:05:59,050
+اسمه single dose protocol و ال protocol التاني
+
+86
+00:05:59,050 --> 00:06:02,690
+اسمه multiply dose protocolبالـ Single dose
+
+87
+00:06:02,690 --> 00:06:06,130
+protocol أنا بعطي dose واحد بمعدل تلاتة milligram
+
+88
+00:06:06,130 --> 00:06:12,750
+في مرحلة ال late follicular stage في ال multiple
+
+89
+00:06:12,750 --> 00:06:16,470
+dose أنا بعطي أكتر من dose بشكل يومي بمعدل ربع
+
+90
+00:06:16,470 --> 00:06:19,850
+milligram من ال analogues اللي هي عبارة عن جولات
+
+91
+00:06:19,850 --> 00:06:22,850
+ربين و raising hormone analogues تبدأ في اليوم
+
+92
+00:06:22,850 --> 00:06:26,010
+الخامس أو السادس من الدورة هذا الفرق بين ال single
+
+93
+00:06:26,010 --> 00:06:31,950
+dose و multiple dose protocolصورة بتوضح الفرق بين
+
+94
+00:06:31,950 --> 00:06:34,490
+ال agonist و ال antagonist لو بدأت انا من ال
+
+95
+00:06:34,490 --> 00:06:37,490
+agonist هى ال hypothalamus هى ال pituitary gland
+
+96
+00:06:37,490 --> 00:06:40,150
+هى ال receptor الخاص بال gonadotropin releasing
+
+97
+00:06:40,150 --> 00:06:44,650
+hormone receptor انا هنا باعطي gonadotropin
+
+98
+00:06:44,650 --> 00:06:47,710
+releasing hormone analogues هترتبط بال receptor
+
+99
+00:06:47,710 --> 00:06:51,190
+فهتحفظ ال receptor الموجودة على ال anterior loop
+
+100
+00:06:51,190 --> 00:06:53,490
+فبتدفع ال anterior loop و ال pituitary gland
+
+101
+00:06:53,490 --> 00:06:58,290
+لإفراز كمية كبيرة جدا من الأفسش و الألاتشفي لحظة
+
+102
+00:06:58,290 --> 00:07:05,030
+معينة تتوقف بتبطل تفرز الـLH والـLH أنا كطبيب ببدأ
+
+103
+00:07:05,030 --> 00:07:09,230
+أعطي الـrecombinant FSH هذا ما نسميه agonist
+
+104
+00:07:09,230 --> 00:07:14,790
+الـantagonist لأ مباشرة المادة اللي تحققن تعمل
+
+105
+00:07:14,790 --> 00:07:18,290
+blocking للـreceptor الموجودة في الـpatietary
+
+106
+00:07:18,290 --> 00:07:22,490
+gland فتعمل على إيقاف الـgonadotropin releasing
+
+107
+00:07:22,490 --> 00:07:29,150
+releasing like FSH and LH فبالتاليبعطي مباشرة ال
+
+108
+00:07:29,150 --> 00:07:32,030
+recombinant همجمون من الخارج هذا الفرق بين ال
+
+109
+00:07:32,030 --> 00:07:38,150
+agonist و ال antagonist طيب بعد ما عرفنا الفرق بين
+
+110
+00:07:38,150 --> 00:07:43,230
+ال agonist و ال antagonist صورة بتوضح و بتعمل
+
+111
+00:07:43,230 --> 00:07:47,290
+summarization لكل ال information اللي احنا اتكلمنا
+
+112
+00:07:47,290 --> 00:07:51,850
+عنها سابقا فلو انا بديت لو نفرض ان عندي هي اليوم
+
+113
+00:07:51,850 --> 00:07:55,470
+الأول من الدورة و هذه الأيام السابقة من الدورة
+
+114
+00:07:55,470 --> 00:08:01,500
+السابقةفي الـ ultra short و short و long و long
+
+115
+00:08:01,500 --> 00:08:06,420
+mid-uteal protocol و agonist هذا كله .. عفوًا هذا
+
+116
+00:08:06,420 --> 00:08:09,940
+antagonist هذا كله agonist اللي فوق ال ultra short
+
+117
+00:08:09,940 --> 00:08:13,980
+لحد دي ال long هذا كله agonist في ال ultra short
+
+118
+00:08:13,980 --> 00:08:17,600
+بدأ من اليوم الأول للدورة أعطى جناد تروبين
+
+119
+00:08:17,600 --> 00:08:21,400
+releasing hormone analogues تلت أيام بعضين أعطى
+
+120
+00:08:21,400 --> 00:08:27,030
+FSH بعضين في اليوم العاشر أعطىالـ human coronary
+
+121
+00:08:27,030 --> 00:08:30,790
+gonadotropin اللي بيعمل ovulation فجدتش أخد أيام
+
+122
+00:08:30,790 --> 00:08:37,270
+تقريبا 10 أيام في ال short اختلف الموضوع أعطى
+
+123
+00:08:37,270 --> 00:08:42,430
+Analogues تلت أيام من الدورة بعدين أعطى FSH plus
+
+124
+00:08:42,430 --> 00:08:45,090
+gonadotropin releasing hormone Analogues علشان
+
+125
+00:08:45,090 --> 00:08:49,050
+يستمر في تحفيز ال anterior loop of pituitary gland
+
+126
+00:08:49,050 --> 00:08:53,150
+من أجل إنتاج ال FSH والLHلما نصل إلى الـ
+
+127
+00:08:53,150 --> 00:08:58,410
+Downregulation حيس يعطي الـ FSH Recomponent ويصل
+
+128
+00:08:58,410 --> 00:09:02,450
+لاداميتر المطلوب للفوليكل من أجل إعطاء الـ Human
+
+129
+00:09:02,450 --> 00:09:06,650
+-Corona-Gonadotropin في الـ Long Protocol المفروض
+
+130
+00:09:06,650 --> 00:09:09,990
+في الـ Long Protocol عندي نوعين Long Protocol في
+
+131
+00:09:09,990 --> 00:09:13,210
+الـ Follicular Stage و Long Protocol في الـ Middle
+
+132
+00:09:13,210 --> 00:09:17,210
+Blutial Stage Long Protocol في الـ Follicular ببدأ
+
+133
+00:09:17,210 --> 00:09:21,010
+من اليوم الأول من الدورة الحالية هيعطي Analogues
+
+134
+00:09:21,010 --> 00:09:26,800
+لمدة13 يوم او 12 يوم بعدين بمجرد ما يصير down
+
+135
+00:09:26,800 --> 00:09:31,280
+regulation هيعطي ال recomponent FSH بمجرد الفلك
+
+136
+00:09:31,280 --> 00:09:35,040
+اللي ما تصل الى 18 ميلي متر او اكبر هيعطي ال HCG
+
+137
+00:09:35,040 --> 00:09:39,420
+اللي سميتها هي human chronic gonadotropin اللي
+
+138
+00:09:39,420 --> 00:09:44,310
+بيشتغل شغل ال LH وهي ال ovulationفي الـ Long
+
+139
+00:09:44,310 --> 00:09:48,230
+Middle Luteal Protocol حيبدأ بإعطاء الجنادو تروبين
+
+140
+00:09:48,230 --> 00:09:51,790
+Releasing Hormone Analogues من آخر عشر أيام في
+
+141
+00:09:51,790 --> 00:09:58,990
+الدورة السابقة ويستمر إلى اليوم السابع
+
+142
+00:09:58,990 --> 00:10:03,710
+من الدورة الحالية تجريبا اليوم السابع أو اليوم
+
+143
+00:10:03,710 --> 00:10:07,690
+التامن، اليوم السابع بعد كده، هيستمر بإعطاء
+
+144
+00:10:07,690 --> 00:10:10,830
+الجنادو تروبين Releasing Hormone حتى يصل إلى مرحلة
+
+145
+00:10:10,830 --> 00:10:14,310
+الـ Down Regulationof anterior lobopertatory gland
+
+146
+00:10:14,310 --> 00:10:19,450
+وقتها هيعطي ال FSH من أجل إنضاج البويضات بمجرد
+
+147
+00:10:19,450 --> 00:10:23,650
+البويضة ما تنضج وتنضج بشكل كامل وتصل الفولكل
+
+148
+00:10:23,650 --> 00:10:28,330
+الأكبر من أو تسبب 18 ميلي متر هيبدأ يعطي هرمون
+
+149
+00:10:28,330 --> 00:10:32,810
+مسئول عن عملية ال ovulation هذه كلها ال protocol
+
+150
+00:10:32,810 --> 00:10:36,530
+هذه الأربع اللي حكينا عنها هي عبارة عن
+
+151
+00:10:36,530 --> 00:10:42,200
+gonadotropin releasing hormone agonistنأتي للـ
+
+152
+00:10:42,200 --> 00:10:46,080
+Antagonist الـ Antagonist ما في عندي Analogues
+
+153
+00:10:46,080 --> 00:10:49,580
+بمعنى آخر، ما في عندي Down Regulation في عندي
+
+154
+00:10:49,580 --> 00:10:55,460
+مباشرة Blocking للـ Receptor الخاصة بالـ FSH
+
+155
+00:10:55,460 --> 00:10:58,760
+والألاتش الموجودة في الـ Anterior Loop فبيعطي FSH
+
+156
+00:10:58,760 --> 00:11:03,260
+مباشرة، بعدين بيعطي FSH Recombinant المسئولة عن
+
+157
+00:11:03,260 --> 00:11:06,920
+عملية إنضاج الفوليكل لما انتصر الفوليكل للحد
+
+158
+00:11:06,920 --> 00:11:09,760
+المطلوب والدياميتر المطلوب، بيعطيها لـ Human
+
+159
+00:11:09,760 --> 00:11:13,750
+Chronic Gonadotropinهذا المقصود فيها Antagonist
+
+160
+00:11:13,750 --> 00:11:18,830
+الـ Agonist Stimulation Releasing Stopping الـ
+
+161
+00:11:18,830 --> 00:11:22,970
+Antagonist Stopping Directly Without Activation،
+
+162
+00:11:22,970 --> 00:11:28,070
+Without Stimulation هذا الفرق ما بين الاتنين طيب،
+
+163
+00:11:28,070 --> 00:11:32,990
+العملية إعطاء الجرأ هادي و إعطاء الهرمونات و إعطاء
+
+164
+00:11:32,990 --> 00:11:35,490
+الـ Analogues و إعطاء الـ F-Acetyl-Component
+
+165
+00:11:35,490 --> 00:11:38,050
+البروتين و إعطاء الـ Human Colonic Gonadotropin
+
+166
+00:11:38,050 --> 00:11:42,090
+المسئول عن الـ Ovulation هل تحدث عبثاً؟هل يجب أن
+
+167
+00:11:42,090 --> 00:11:45,370
+تخضأ إلى عملية monitoring؟ لأ يجب أن تخضأ إلى
+
+168
+00:11:45,370 --> 00:11:49,210
+عملية monitoring بشكل مستمر حتى بعض المختبرات و
+
+169
+00:11:49,210 --> 00:11:54,130
+بعض المراكز بتعمل monitoring يوم بيوم كل يوم لازم
+
+170
+00:11:54,130 --> 00:11:58,590
+الزوجة تيجي تعمل E2 level examination و تعمل
+
+171
+00:11:58,590 --> 00:12:02,190
+vaginal ultrasound examination يعني انا بحدد مستوى
+
+172
+00:12:02,190 --> 00:12:08,970
+ال E2 و باخد صورة للأوبري والرحم بشكل مستمر بعد
+
+173
+00:12:08,970 --> 00:12:13,260
+الدراسات جالتE2 level is used to determine the
+
+174
+00:12:13,260 --> 00:12:16,800
+dose of gonadotropin and if under or over
+
+175
+00:12:16,800 --> 00:12:20,720
+stimulation okay يعني جدش انا فيه عندى E2 جدش
+
+176
+00:12:20,720 --> 00:12:25,300
+المفروض يكون فيه عندى بوايضة لأن كل بوايضة بتفرز
+
+177
+00:12:25,300 --> 00:12:29,240
+كمية معينة من ال E2 لو انا حددت جدش عندى كمية ال
+
+178
+00:12:29,240 --> 00:12:34,760
+E2 وجسمت على كمية ال E2 المفرز من كل بوايضة هعرف
+
+179
+00:12:34,760 --> 00:12:40,000
+تقديرا إلى حد اللي ما جدش عندي mature oversightبعض
+
+180
+00:12:40,000 --> 00:12:45,300
+الدراسات قالت إن الـ E2 ليس له أهمية يكفي أن نعمل
+
+181
+00:12:45,300 --> 00:12:48,280
+monitoring من خلال ما يُعرف باسم الـ vaginal
+
+182
+00:12:48,280 --> 00:12:53,340
+ultrasound examination and so the E2 level is not
+
+183
+00:12:53,340 --> 00:12:56,520
+necessary is not always necessary and the response
+
+184
+00:12:56,520 --> 00:12:59,160
+to the treatment can be followed by ultrasound
+
+185
+00:12:59,160 --> 00:13:02,800
+monitoring only the goal for ovarian hyper
+
+186
+00:13:02,800 --> 00:13:07,740
+stimulation is to develop at least three mature
+
+187
+00:13:07,740 --> 00:13:14,410
+oocyteأو 3 mature follicle الديامتر أكبر من أو
+
+188
+00:13:14,410 --> 00:13:20,670
+يساوي 18 مليلتر بعضهم بيديني لأ بيكفلي 18 بدي يكون
+
+189
+00:13:20,670 --> 00:13:26,090
+الديامتر من 22 ل 24 بس كحد أخدنا 18 و يطلع لازم
+
+190
+00:13:26,090 --> 00:13:31,530
+يكون ال follicle as diameter 18 مليمتر طيب لما نصل
+
+191
+00:13:31,530 --> 00:13:36,020
+أو تصل ال follicle لديامتر المطلوباقتصى للدياميتر
+
+192
+00:13:36,020 --> 00:13:39,960
+المطلوب يكون 18 ميلي متر ال FSH و الاخرى مدعومين
+
+193
+00:13:39,960 --> 00:13:44,880
+مستمرين و الانجيكشن الوحيد من الهيومان كورونادو
+
+194
+00:13:44,880 --> 00:13:48,060
+تروبيل يجب أن يتم إعطاءه لتعامل الفوليكين و يسمح
+
+195
+00:13:48,060 --> 00:13:52,260
+له فرتاليز يعني وصلت الفوليكين لحد المطلوب و وصلت
+
+196
+00:13:52,260 --> 00:13:56,420
+للدياميتر المطلوبة خلاص بواجف اعطاء ال FSH و ال
+
+197
+00:13:56,420 --> 00:13:59,140
+medication الأخرى او ال injection الأخرى و بعطي
+
+198
+00:13:59,140 --> 00:14:04,020
+injection واحدة بهرمون اسمه HCG hormone واضيف
+
+199
+00:14:04,020 --> 00:14:07,730
+تقولناتشبه وظيفة الـLH وهي مسئولة عن الـ ovulation
+
+200
+00:14:07,730 --> 00:14:12,770
+الـ HCG لـ administration will be cause ovulation
+
+201
+00:14:12,770 --> 00:14:17,550
+so it is equal in the function like LH but this
+
+202
+00:14:17,550 --> 00:14:22,290
+does not occur until 36 to 40 hours after the
+
+203
+00:14:22,290 --> 00:14:26,750
+injection طبعا عملية ال ovulation ما بتحدث بشكل
+
+204
+00:14:26,750 --> 00:14:31,430
+مباشر لأتحدث بعد 36 إلى 40 ساعة من ال injection
+
+205
+00:14:31,430 --> 00:14:37,110
+يعني لو أنا أعطيت الزوجة ال HCG الساعة 4 العصر عيد
+
+206
+00:14:37,110 --> 00:14:41,070
+36 ساعة إلى 40 ساعة خلال الفترة هذه لازم يصير عندي
+
+207
+00:14:41,070 --> 00:14:45,970
+ovulation therefore it is standard that the HCG
+
+208
+00:14:45,970 --> 00:14:49,990
+injection is administrated 36 hours before the
+
+209
+00:14:49,990 --> 00:14:55,230
+schedule egg collected such thatthis will allow a
+
+210
+00:14:55,230 --> 00:14:58,790
+quieted maturation of the oocyte and yet there
+
+211
+00:14:58,790 --> 00:15:02,090
+would be little risk for ovulation علشان كده مهم
+
+212
+00:15:02,090 --> 00:15:05,130
+جدا انت كانسان بيشتغل في هذا المجال انك تعمل
+
+213
+00:15:05,130 --> 00:15:09,050
+schedule time table time انا لو اعطيت السيدة هذه
+
+214
+00:15:09,050 --> 00:15:15,550
+ال hcg الساعة كده الساعة الخامسة متى المفروض اجمع
+
+215
+00:15:15,550 --> 00:15:18,250
+البويضات الستة و تلاتين ساعة نهايتها متى هتكون
+
+216
+00:15:18,250 --> 00:15:21,990
+علشان اشوف هل جدوة اللي بسمح ولا لأ لأنه مش منطق
+
+217
+00:15:21,990 --> 00:15:26,370
+اخليهابعد 36 ساعة انتظر انه ممكن يصير ovulation
+
+218
+00:15:26,370 --> 00:15:29,550
+انا مابدي يصير ovulation انا بدي اصل الى لحظة ال
+
+219
+00:15:29,550 --> 00:15:32,710
+ovulation قبلها بقليل و ادخل بالنيد الوهم ال
+
+220
+00:15:32,710 --> 00:15:38,070
+aspiration هاي المقصود بالموضوع ايجينا مصطلح مهم
+
+221
+00:15:38,070 --> 00:15:42,270
+جدا كلمنا عنه باختصار شديد في البداية المحاضرة
+
+222
+00:15:42,270 --> 00:15:46,170
+السابقة وهي ovarian hyper stimulation syndrome ال
+
+223
+00:15:46,170 --> 00:15:48,770
+ovarian hyper stimulation syndrome هو عبارة عن
+
+224
+00:15:48,770 --> 00:15:53,910
+حالة ومظهريحدث عند السيدات اللى ممكن يخضعوا لل
+
+225
+00:15:53,910 --> 00:15:57,090
+injection أو ال induction أو ال stimulation
+
+226
+00:15:57,090 --> 00:16:02,670
+فبالتالي بيصير عندى مشكلة في مستوى الهرمونات
+
+227
+00:16:02,670 --> 00:16:07,390
+treatment that taking hormone as injection or a
+
+228
+00:16:07,390 --> 00:16:12,230
+drug to stimulation the ovary and increase the
+
+229
+00:16:12,230 --> 00:16:18,750
+number of oocyte it will be evaluated ovulated it
+
+230
+00:16:18,750 --> 00:16:23,890
+will be ovulatedBut there are rare cases of OHSS
+
+231
+00:16:23,890 --> 00:16:27,150
+occurring spontaneously يعني بوضع الطبيعي أن هذا
+
+232
+00:16:27,150 --> 00:16:30,910
+المرض أو هذه الحالة أو هذه ال case اللي سميتها
+
+233
+00:16:30,910 --> 00:16:34,170
+ovarian hyperstimulation syndrome ما بتحدث في شكل
+
+234
+00:16:34,170 --> 00:16:38,210
+تلقائي إلا في عدد قليل جدا لا يذكر معظم الحالات
+
+235
+00:16:38,210 --> 00:16:40,790
+اللي تم تأكيدها أنها ovarian hyperstimulation
+
+236
+00:16:40,790 --> 00:16:44,910
+syndrome بتكون لسيدات خضعوا إلى ال ovarian
+
+237
+00:16:44,910 --> 00:16:50,260
+induction أو ال ovarian stimulationطيب ال OHSS
+
+238
+00:16:50,260 --> 00:16:52,620
+happened during fertility treatment using
+
+239
+00:16:52,620 --> 00:17:00,400
+medication you take by mouth such as Clomipherine
+
+240
+00:17:00,400 --> 00:17:04,000
+يعني بعض السيدات ممكن تكون ماخدة fertility
+
+241
+00:17:04,000 --> 00:17:10,920
+treatment عن طريق ال mouth فممكن يظهر عندها زي
+
+242
+00:17:10,920 --> 00:17:14,640
+عفوا ال Clomipherine فممكن يظهر عندها ما يعرف باسم
+
+243
+00:17:14,640 --> 00:17:20,440
+ال OHSSالـ excessive dose للهرمونات التي تُعطى
+
+244
+00:17:20,440 --> 00:17:28,720
+بدون أي رقابة قد تؤدي إلى حدوث OHSS مما يصاحبه من
+
+245
+00:17:28,720 --> 00:17:34,180
+زيادة في حجم المبيض، تضخم في حجم المبيض، ظهور للـ
+
+246
+00:17:34,180 --> 00:17:37,720
+cyst حوالين المبيض، وضفق لكمية كبيرة جدا من ال
+
+247
+00:17:37,720 --> 00:17:43,600
+fluid في الـ intravascular space فبالتالي قسموا من
+
+248
+00:17:43,600 --> 00:17:48,470
+حيث ال severity إلى moderate و severeقسموا من حيث
+
+249
+00:17:48,470 --> 00:17:52,890
+بقض الحدوث إلى Early وLate قسموا من حيث الأسباب
+
+250
+00:17:52,890 --> 00:17:59,790
+إلى spontaneous وحاجة بنتسموها heterogenic وهي
+
+251
+00:17:59,790 --> 00:18:03,930
+عبارة عن حالة مرضية تحدث بالفعل تناول السيدة
+
+252
+00:18:03,930 --> 00:18:08,150
+لهرمونات عن طريق ال mouth أو عن طريق ال injection
+
+253
+00:18:08,150 --> 00:18:17,960
+ال Early OHSS تظهربعد عملية ال ovulation بعد ال
+
+254
+00:18:17,960 --> 00:18:22,700
+ovulatory dose بتلت إلى سبع أيام of the HCG where
+
+255
+00:18:22,700 --> 00:18:27,260
+as ال late من 12 إلى 17 دقيقة يعني وين اليوم اللي
+
+256
+00:18:27,260 --> 00:18:34,400
+تم اعطاء الزوج ال HCG ممكن يظهر ال OHSS إذا ظهر من
+
+257
+00:18:34,400 --> 00:18:38,500
+اتنين لتلت أيام بعد ال ovulation بيكون early إذا
+
+258
+00:18:38,500 --> 00:18:43,040
+ظهر بعد اتناشر يوم بيكون lateمشكلة أكتر لـ Ovarian
+
+259
+00:18:43,040 --> 00:18:48,540
+hyperstimulation syndrome هي أتاروجينك بسبب إعطاء
+
+260
+00:18:48,540 --> 00:18:54,100
+الجونادوتروبين الهرمون كمية قليلة جدا تحدث بفعل
+
+261
+00:18:54,100 --> 00:18:58,900
+spontaneous قد تكون بفعل الـ mutation أثرت على الـ
+
+262
+00:18:58,900 --> 00:19:02,500
+receptor المسؤول عن استقبال الـ FSH و الـLH مما
+
+263
+00:19:02,500 --> 00:19:06,580
+أدى إلى حدوث الـ Ovarian hyperstimulation syndrome
+
+264
+00:19:06,580 --> 00:19:11,590
+الذي يؤثر على الـ pregnancy بشكل عامEvarian
+
+265
+00:19:11,590 --> 00:19:14,550
+hyperstimulation syndrome, we can classify it
+
+266
+00:19:14,550 --> 00:19:17,750
+according to the severity into mild, moderate,
+
+267
+00:19:18,310 --> 00:19:23,070
+severe وفي بعض الأحيان بيسموه critical grade الـ
+
+268
+00:19:23,070 --> 00:19:27,270
+mild الـ ovary إذا أنا قسته عن طريق ال ultrasound
+
+269
+00:19:27,270 --> 00:19:31,490
+هيكون أقل من 8 cm و في الغالب بيكون عندها mild ال
+
+270
+00:19:31,490 --> 00:19:35,630
+symptoms اللي علاقة بالأبدومير المoderate إذا أنا
+
+271
+00:19:35,630 --> 00:19:39,030
+قست ال ovary من خلال ال ultrasound هيكون من 8 إلى
+
+272
+00:19:39,030 --> 00:19:47,730
+12الـ fluid حوالين الـ abdominal البريتونيوم في
+
+273
+00:19:47,730 --> 00:19:51,610
+الـ severe هيكون ال diameter بتاع ال ovary أكتر من
+
+274
+00:19:51,610 --> 00:19:57,010
+12 صنطي و هذه حالة مقلقة إلى حد ما بالنسبة ل ال
+
+275
+00:19:57,010 --> 00:19:59,890
+mild و ال moderate ال symptoms بصير عندها
+
+276
+00:19:59,890 --> 00:20:04,550
+abdominal pain السيدة بصير عندها زيادة في محيط
+
+277
+00:20:04,550 --> 00:20:09,190
+الخسر و عندها انتفاخات بصير عندها adenasia و
+
+278
+00:20:09,190 --> 00:20:12,880
+vomiting دياريابصير في عندها تصلب في منطقة الـ
+
+279
+00:20:12,880 --> 00:20:16,000
+ovary أيضًا الـ severe ovarian hyperstimulation
+
+280
+00:20:16,000 --> 00:20:19,620
+syndrome بصير في عندها rapid weight تكتسب
+
+281
+00:20:19,620 --> 00:20:25,500
+increasing in the body weight بشكل سريع جدًا بمعدل
+
+282
+00:20:25,500 --> 00:20:29,620
+1 kilogram لكل 24 ساعة بصير عندها abdominal pain
+
+283
+00:20:29,620 --> 00:20:32,520
+بصير عندها nasal vomiting very severe بصير عندها
+
+284
+00:20:32,520 --> 00:20:34,760
+decrease في ال urination بصير في عندها blood
+
+285
+00:20:34,760 --> 00:20:38,940
+clotting بصير في عندها problem in the breathing
+
+286
+00:20:38,940 --> 00:20:42,290
+short breathingبصير عندها أيضًا enlargement في
+
+287
+00:20:42,290 --> 00:20:47,890
+منطقة الـ Tide ومنطقة الـ Abdomen طب إيش العامل
+
+288
+00:20:47,890 --> 00:20:50,310
+اللي ممكن يتزيد من فرصة حدوث الـ Ovarian
+
+289
+00:20:50,310 --> 00:20:54,370
+Hyperstimulation Syndrome؟ أول عامل وأختارهم هو
+
+290
+00:20:54,370 --> 00:20:57,630
+الـ Polycystic Ovarian Syndrome الـ Polycystic
+
+291
+00:20:57,630 --> 00:21:02,030
+Ovarian Syndrome حالة مرضية بتعاني منها بعض
+
+292
+00:21:02,030 --> 00:21:06,910
+السيدات اللي لهم أصلاً history خاص بالـ Polycystic
+
+293
+00:21:06,910 --> 00:21:11,970
+Ovarian Syndromeمشكلة polycystic ovarian syndrome
+
+294
+00:21:11,970 --> 00:21:16,730
+هو بيظهر سيست في منطقة الـ ovary مما يؤدي إلى
+
+295
+00:21:16,730 --> 00:21:19,910
+خربطة في ال menstrual cycle بيبقى ال menstrual
+
+296
+00:21:19,910 --> 00:21:24,810
+cycle مش منتظمة طبعا هذا بيمنع الإنجاب أو يؤخر
+
+297
+00:21:24,810 --> 00:21:28,690
+الإنجاب ولكن لا يمنعه بشكل مطلق ممكن لو تم إزالة
+
+298
+00:21:28,690 --> 00:21:35,460
+السيست مع إلاجات ترجع السيدة تنجب بشكل طبيعيممكن
+
+299
+00:21:35,460 --> 00:21:39,880
+ال risk factor يزيد لو تم اعطاء الزوجة او السيدة
+
+300
+00:21:39,880 --> 00:21:43,780
+دوز عالي من ال human كوروناتروبين خلال ال IVF
+
+301
+00:21:43,780 --> 00:21:50,260
+cycle او اعطت large number of follicles ممكن بعضهم
+
+302
+00:21:50,260 --> 00:21:57,840
+يكون free امرها اقل من 35 ال body weight very low
+
+303
+00:21:57,840 --> 00:22:03,440
+او عندها في تاريخ الطب اصابات سابقة بال ovarian
+
+304
+00:22:03,440 --> 00:22:08,780
+hyper stimulationSo what is the complication؟
+
+305
+00:22:08,780 --> 00:22:11,760
+الكمبليكيشن لهذه الحالة المرضية أول حاجة بتسميها
+
+306
+00:22:11,760 --> 00:22:16,320
+من الكمبليكيشن وجود imbalance في ال electrolyte
+
+307
+00:22:16,320 --> 00:22:20,300
+وذلك بسبب severe fluid will be shifted out of the
+
+308
+00:22:20,300 --> 00:22:22,060
+blood vessels may be effected on the blood
+
+309
+00:22:22,060 --> 00:22:26,120
+pressure أنه بيصير في shifting كمية كبيرة جدا من
+
+310
+00:22:26,120 --> 00:22:31,000
+السواعر من الدموية إلى الفراغ ما بين الخلايافهذا
+
+311
+00:22:31,000 --> 00:22:36,020
+يجعل لدي الـ Electrolyte imbalance في عندي status
+
+312
+00:22:36,020 --> 00:22:41,620
+of thrombotic abnormality وذلك بفعل عند وجود خلل
+
+313
+00:22:41,620 --> 00:22:45,980
+في الأستروجين لأن الأستروجين بيلعب دور مهم جدا as
+
+314
+00:22:45,980 --> 00:22:51,060
+a pro-coagulant hormone one may develop
+
+315
+00:22:51,060 --> 00:22:55,460
+hemoconcentration and cause abnormal blood clot in
+
+316
+00:22:55,460 --> 00:23:01,660
+large vessels usually lower limbفي عندى مشكلة في
+
+317
+00:23:01,660 --> 00:23:07,020
+مستوى الأستروجين في السيدات اللى عندهم ovarian
+
+318
+00:23:07,020 --> 00:23:11,240
+hyperstimulation syndrome فبصير عندهم مشاكل في ال
+
+319
+00:23:11,240 --> 00:23:14,200
+coagulation cascade أو ال coagulation status أو ال
+
+320
+00:23:14,200 --> 00:23:18,640
+thrombotic status بفعل وجود خلل في الأستروجين لإن
+
+321
+00:23:18,640 --> 00:23:21,920
+الأستروجين في الأصل بيشتغل ك pro-coagulant hormone
+
+322
+00:23:21,920 --> 00:23:25,320
+فيممكن يصير عندها من أحد ال complications kidney
+
+323
+00:23:25,320 --> 00:23:32,200
+فالية مشاكل في ال ovaryالتوقعات في الـ Ovary يصير
+
+324
+00:23:32,200 --> 00:23:34,780
+في عندي rupture للسست الموجودة مما يؤدي إلى حدوث
+
+325
+00:23:34,780 --> 00:23:38,180
+ال bleeding ممكن يصير عندي مشكلة في ال breathing
+
+326
+00:23:38,180 --> 00:23:41,540
+ماتقدر تاخد نفسها بفعل كمية كبيرة جدا من ال fluid
+
+327
+00:23:41,540 --> 00:23:45,420
+اللي تسربت فتضغط على الرؤى ممكن يصير عندها
+
+328
+00:23:45,420 --> 00:23:48,880
+abortion, miscarriage ممكن يؤدي إلى ال death في
+
+329
+00:23:48,880 --> 00:23:53,300
+بعض الحالات سجلات سيدات بسبب النزيف الداخلي العصبي
+
+330
+00:23:53,300 --> 00:23:56,700
+مثلًا بسبب كمية ال fluid الموجودة على الرؤتين بفعل
+
+331
+00:23:56,700 --> 00:23:59,580
+أحد ال complicationsفي فئة ال bleeding هذه كلها
+
+332
+00:23:59,580 --> 00:24:03,320
+إذا كانت مافي monitoring مافي treatment قد تؤدي
+
+333
+00:24:03,320 --> 00:24:09,100
+إلى الوفاة فبالتالي كيف يمكن تجنب هذا القمر ال
+
+334
+00:24:09,100 --> 00:24:14,080
+prevention من خلال أول حاجة أن أعمل evaluation و
+
+335
+00:24:14,080 --> 00:24:19,520
+adjusting ل ال medication الدكتور و الطبيب المعالج
+
+336
+00:24:19,770 --> 00:24:23,790
+لازم يتأكد من كمية من الجرعة وكيفية يعطاها ويعطاها
+
+337
+00:24:23,790 --> 00:24:28,110
+بالشكل السريب الجرعة المناسبة تحدد من خلال عدد
+
+338
+00:24:28,110 --> 00:24:33,690
+الـboilers التي تؤهل للنضوج كيف هي استجابة المبيض
+
+339
+00:24:33,690 --> 00:24:38,510
+للـanalogues اللتي تُعطى أو للهرمونات اللتي تُعطى
+
+340
+00:24:38,510 --> 00:24:42,810
+أيضًا، some medications seem to reduce the risk of
+
+341
+00:24:42,810 --> 00:24:45,510
+ovarian hyperstimulation syndrome without
+
+342
+00:24:45,510 --> 00:24:49,710
+affecting the odds of pregnancyبعض الأحيان فيه
+
+343
+00:24:49,710 --> 00:24:54,850
+medication توصف تتأدي إلى خفض معدل أو risk factor
+
+344
+00:24:54,850 --> 00:24:58,030
+لهذا الحالة أو لهذا المرض ولكن ما بتأثر على ال
+
+345
+00:24:58,030 --> 00:25:01,790
+fertility و ما بتأثر على ال pregnancy ايضا بياضف
+
+346
+00:25:01,790 --> 00:25:06,610
+إلى ذلك من اهم الأمور التثبيت او الهبوط ايش يعني
+
+347
+00:25:06,610 --> 00:25:10,890
+التثبيت او الهبوط يعني انا ممكن اقلل الجرعة ببساطة
+
+348
+00:25:10,890 --> 00:25:14,870
+جدا ما اخليها ع جرعة واحدة if your estrogen for
+
+349
+00:25:14,870 --> 00:25:19,170
+example level is very high or you havea large
+
+350
+00:25:19,170 --> 00:25:21,950
+number of development follicle your doctor may
+
+351
+00:25:21,950 --> 00:25:25,630
+have you stop injectable medication and wait a few
+
+352
+00:25:25,630 --> 00:25:29,870
+days يعني والله خمس أيام بيعطيها جرعة معينة من
+
+353
+00:25:29,870 --> 00:25:35,310
+الهرمونات لجى فجأة الاستروجين عالي جدا عمل ال
+
+354
+00:25:35,310 --> 00:25:38,710
+ultrasound كمية كبيرة جدا او عدد لبأس فيه من ال
+
+355
+00:25:38,710 --> 00:25:43,650
+follicle قريب انه ينضج يصير mature مافي عندي مشكلة
+
+356
+00:25:43,650 --> 00:25:47,330
+لو وقفت عملية ال injection يوم يومين تلاتة اربع
+
+357
+00:25:47,330 --> 00:25:52,210
+حتىأؤخر عملية الـ maturation وما أخلى الزوجة أو
+
+358
+00:25:52,210 --> 00:25:54,390
+السيدة تدخل في الـ ovarian hyperstimulation
+
+359
+00:25:54,390 --> 00:25:59,310
+syndrome بعد كده أرجع أعطيها الهرمونات مرة جديدة
+
+360
+00:25:59,310 --> 00:26:02,270
+لاستكمال عملية ال ovarian أو الfurricular
+
+361
+00:26:02,270 --> 00:26:06,270
+maturation هذا ما في عندها مشكلة أنه أهبط و أخفض
+
+362
+00:26:06,270 --> 00:26:10,450
+الجرعة مافي مشكلة أيضا حاجة مهمة جدا أن نعمل
+
+363
+00:26:10,450 --> 00:26:14,370
+cancel ال cycle cancellation او canceling cycleمش
+
+364
+00:26:14,370 --> 00:26:18,190
+غلط انه انا لو كان معظم المعايير و المؤشرات
+
+365
+00:26:18,190 --> 00:26:20,870
+بتقولوا ان هذه الزوجة او هذه السيدة هتروح لل
+
+366
+00:26:20,870 --> 00:26:24,730
+ovarian hyper stimulation syndrome مش غلط ان اوجف
+
+367
+00:26:24,730 --> 00:26:28,130
+ال cycle و اعمل dropping و اعمل canceling لل cycle
+
+368
+00:26:28,130 --> 00:26:32,450
+و اريح السيدة شهر شهرين تلاتة و ارجع من أوله جديد
+
+369
+00:26:32,450 --> 00:26:42,090
+في cycle جديدة مش غلط يعني خسارة قريبة أفضل من ما
+
+370
+00:26:42,090 --> 00:26:48,720
+اكسب بعيدمهم جدا ان انا اوقف الـ cycle اوقف ال
+
+371
+00:26:48,720 --> 00:26:51,760
+stimulation اوقف ال induction في الوقت المناسب
+
+372
+00:26:51,760 --> 00:26:57,260
+holding HCG used to be the most common method used
+
+373
+00:26:57,260 --> 00:27:00,240
+to prevent ovarian hyperstimulation syndrome in
+
+374
+00:27:00,240 --> 00:27:03,480
+patients predicted to be at high risk for
+
+375
+00:27:03,480 --> 00:27:05,460
+development or to development of ovarian
+
+376
+00:27:05,460 --> 00:27:09,480
+hyperstimulation syndrome بمعنى اخر انه حكوا
+
+377
+00:27:09,870 --> 00:27:16,650
+العلماء أن أي سيدة مستوى الاستروجين بيكون أكبر من
+
+378
+00:27:16,650 --> 00:27:23,770
+أو يساوي 4000 Pg per ml هذه السيدة مؤهلة للدخول في
+
+379
+00:27:23,770 --> 00:27:27,190
+الـ Ovarian Hyper Stimulation صندوق فبالتالي قدامك
+
+380
+00:27:27,190 --> 00:27:31,110
+حال من الإتنين يا تخفض الدوز أو توقفها مؤقت أو
+
+381
+00:27:31,110 --> 00:27:36,910
+توقف عملية ال induction equal or more important
+
+382
+00:27:36,910 --> 00:27:40,700
+and criticalfor cancelling cycle than estradiol
+
+383
+00:27:40,700 --> 00:27:46,100
+level are the number of follicle اربعة تمانية
+
+384
+00:27:46,100 --> 00:27:49,820
+لعشرة ملي متر follicle that maybe have acquired
+
+385
+00:27:49,820 --> 00:27:55,740
+الاتش ريسبتور خد بجنب ال E2 جدش عندي عدد ال
+
+386
+00:27:55,740 --> 00:27:58,620
+follicle اللي وصلت ل تمانية لعشرة ملي متر يعني
+
+387
+00:27:58,620 --> 00:28:02,740
+ضايقها اربعة ملي متر و تصل ل ال mature ممكن يكون
+
+388
+00:28:02,740 --> 00:28:06,500
+عندي ما تقدر تصل ل ال mature فبالتالي هعضيها دوز
+
+389
+00:28:06,500 --> 00:28:10,910
+عاليهستمر في عضاء الدوز يعني كأني بجبر المبيض انه
+
+390
+00:28:10,910 --> 00:28:14,210
+ينضج لأكبر عدد من الـ follicle التي تحتوي على
+
+391
+00:28:14,210 --> 00:28:18,270
+البويضات الناضجة وهذا مشكلة بيقع فيها بعض الأطباء
+
+392
+00:28:18,270 --> 00:28:21,910
+انه ما بياخدوا القرار المناسب في الوقت المناسب من
+
+393
+00:28:21,910 --> 00:28:27,090
+أجل إيقاف الدورة أو انقاص الدوز أو إيقاف الدوز ولو
+
+394
+00:28:27,090 --> 00:28:31,430
+بشكل مؤقت هذه الأمور المتعلقة بالـ ovarian
+
+395
+00:28:31,430 --> 00:28:36,320
+hyperstimulation syndrome بالإضافة إلىالكمبليكيشن
+
+396
+00:28:36,320 --> 00:28:40,300
+ال risk factor وكيف ممكن نعمل presentation أو نعمل
+
+397
+00:28:40,300 --> 00:28:44,760
+avoiding لل ovarian hyperstimulation syndrome سوف
+
+398
+00:28:44,760 --> 00:28:48,360
+نتوقف عند هذا الكام من المعلومات في هذه المحاضرة
+
+399
+00:28:48,360 --> 00:28:52,340
+على أمل أن نلتقي في محاضرات قادمة ان شاء الله دوم
+
+400
+00:28:52,340 --> 00:28:53,540
+دوم في حفظ الله
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/Vk4A33MkSlQ_raw.json b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/Vk4A33MkSlQ_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..c3169f68a7f78c71886a560e7c7d55ca497eaa74
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/Vk4A33MkSlQ_raw.json
@@ -0,0 +1 @@
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plus to minus في اليوم التاني ونص جريبا علشان نتصل اليوم التالت وهي 8 من 8 ل 16 خلية في اليوم التالت 16 خلية اللي بتسميها morela في اليوم الرابع تصير 58 خلية بتسميها plus to sixth", "tokens": [2407, 3224, 1829, 6225, 3555, 9640, 3660, 18871, 4724, 45865, 11242, 3660, 5296, 4587, 33753, 5551, 3615, 9566, 2655, 22653, 8978, 45595, 20498, 16247, 12610, 16490, 1211, 36081, 9957, 25961, 2655, 472, 5438, 8608, 2304, 36081, 11296, 382, 286, 658, 39182, 9957, 1975, 2655, 4587, 38251, 2655, 16712, 1211, 2655, 5296, 732, 5438, 23758, 8978, 45595, 20498, 16247, 12610, 8978, 45595, 20498, 16712, 7649, 1829, 5551, 3215, 2655, 22653, 5551, 25513, 3615, 16490, 15040, 25528, 28242, 16490, 1211, 10632, 39894, 38251, 1829, 11296, 1804, 281, 3175, 8978, 45595, 20498, 16712, 7649, 1829, 4032, 1863, 9381, 10874, 16572, 3555, 995, 11203, 8592, 7649, 8717, 2655, 36520, 45595, 20498, 16712, 6027, 2655, 4032, 3224, 1829, 1649, 9154, 1649, 5296, 3165, 16490, 1211, 10632, 8978, 45595, 20498, 16712, 6027, 2655, 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يعني هتبارع عن ال protein plus carbohydrate الـ Zoonopelucida بتلعب دور كبير جدًا في عملية ال protection بتلعب دور كبير جدًا في عملية ال embryo development", "tokens": [2407, 6027, 41779, 9566, 33962, 9640, 7435, 1829, 34051, 9673, 5016, 1829, 9566, 33962, 9640, 7435, 1829, 34051, 2423, 21292, 19986, 3660, 33962, 9640, 7435, 10632, 9122, 15042, 5551, 3794, 46538, 8315, 8608, 16758, 4587, 14111, 995, 8032, 1211, 5296, 11296, 6225, 2407, 10943, 1211, 5551, 34740, 7578, 4032, 19913, 16373, 5172, 5551, 34740, 7578, 22807, 5551, 4117, 25708, 5296, 11296, 4032, 19913, 16373, 5172, 5551, 34740, 7578, 4032, 19913, 16373, 5172, 13412, 2655, 3660, 2423, 39184, 1176, 4106, 404, 338, 1311, 2887, 44945, 2288, 2304, 11622, 30731, 20666, 39184, 1176, 33, 4032, 3555, 2655, 2655, 30544, 8978, 6024, 118, 6027, 3555, 9154, 47286, 482, 22633, 13084, 81, 1370, 259, 37495, 22653, 8032, 2655, 3555, 9640, 3615, 18871, 2423, 7944, 1804, 47048, 2423, 39184, 1176, 4106, 404, 338, 1311, 2887, 39894, 1211, 3615, 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function الخاصة فيها بعد كده كيف يمكن أن نعمل على ترقيق الزونا بليوسيدا بمعنى آخر في الحقن المجهري جاب العملية ال embryo transfer أو إرجاع ال embryo لازم أعمل حاجة بنسميها thinning يعني بمعنى آخر", "tokens": [40228, 22653, 5551, 24401, 5551, 35457, 16758, 2423, 39184, 308, 349, 40216, 16120, 33962, 1211, 1211, 8978, 6024, 110, 2407, 8315, 4724, 20292, 41779, 25708, 995, 23032, 1829, 3555, 4032, 36520, 2655, 11331, 28480, 8315, 5551, 16095, 10632, 6024, 110, 2407, 8315, 4724, 20292, 41779, 25708, 995, 2423, 2445, 33962, 33546, 3660, 8978, 11296, 39182, 9122, 3215, 3224, 9122, 33911, 7251, 43020, 14739, 8717, 25957, 1211, 15844, 6055, 2288, 38436, 4587, 6024, 110, 2407, 8315, 4724, 20292, 41779, 25708, 995, 4724, 2304, 3615, 1863, 7578, 19753, 34740, 8978, 21542, 4587, 1863, 9673, 7435, 3224, 16572, 10874, 16758, 18863, 42213, 10632, 2423, 31588, 78, 5003, 34051, 11933, 47341, 45761, 2423, 31588, 78, 5296, 31377, 2304, 5551, 25957, 1211, 11331, 26108, 3660, 44945, 38251, 1829, 11296, 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1690.75, "word": " Assisted", "probability": 0.839599609375}, {"start": 1690.75, "end": 1691.21, "word": " Hatching", "probability": 0.90869140625}, {"start": 1691.21, "end": 1691.87, "word": " ولا", "probability": 0.51611328125}, {"start": 1691.87, "end": 1692.19, "word": " حالات", "probability": 0.9879557291666666}, {"start": 1692.19, "end": 1692.85, "word": " معينة؟", "probability": 0.916015625}], "temperature": 1.0}, {"id": 65, "seek": 171903, "start": 1692.93, "end": 1719.03, "text": "في حالات معينة مهم جدا بل لاجب يجب بشكل واجب أنه يعمل assist hatching قبل ما يعمل embryo transfer من أشهر هذه الحالات السيدات اللي عندهم recurrent failure of embryo implantation after embryo transfer يعني عند سيدة خضعت للإجزي تلت أربع أو خمس مرات كل مرة برجع جنين بيصير عنده فشل في ال implantation فبالتالي النتيجة negative", "tokens": [41185, 11331, 6027, 9307, 20449, 9957, 3660, 3714, 16095, 10874, 28259, 4724, 1211, 5296, 26108, 3555, 7251, 7435, 3555, 4724, 8592, 28820, 4032, 26108, 3555, 14739, 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"word": " وراثية", "probability": 0.95498046875}, {"start": 2134.01, "end": 2134.43, "word": " خاصة", "probability": 0.9765625}, {"start": 2134.43, "end": 2134.93, "word": " بالجنين", "probability": 0.985107421875}, {"start": 2134.93, "end": 2135.59, "word": " أو", "probability": 0.91162109375}, {"start": 2135.59, "end": 2135.99, "word": " أحصل", "probability": 0.9812825520833334}, {"start": 2135.99, "end": 2136.19, "word": " على", "probability": 0.93505859375}, {"start": 2136.19, "end": 2136.51, "word": " مادة", "probability": 0.9895833333333334}, {"start": 2136.51, "end": 2137.01, "word": " وراثية", "probability": 0.98916015625}, {"start": 2137.01, "end": 2137.47, "word": " خاصة", "probability": 0.9754231770833334}, {"start": 2137.47, "end": 2137.89, "word": " بالأم", "probability": 0.9767252604166666}, {"start": 2137.89, "end": 2138.39, "word": " من", "probability": 0.9482421875}, {"start": 2138.39, "end": 2138.79, "word": " أجل", "probability": 0.99560546875}, {"start": 2138.79, "end": 2139.61, "word": " الفحوصات", "probability": 0.94970703125}, {"start": 2139.61, "end": 2140.19, "word": " الوراثية", "probability": 0.98603515625}, {"start": 2140.19, "end": 2140.47, "word": " التي", "probability": 0.86865234375}, {"start": 2140.47, "end": 2141.27, "word": " تسمى", "probability": 0.8759765625}, {"start": 2141.27, "end": 2141.75, "word": " pre", "probability": 0.290283203125}, {"start": 2141.75, "end": 2142.71, "word": "-implantation", "probability": 0.82989501953125}, {"start": 2142.71, "end": 2143.13, "word": " genetic", "probability": 0.912109375}, {"start": 2143.13, "end": 2143.75, "word": " testing", "probability": 0.8515625}, {"start": 2143.75, "end": 2144.23, "word": " يعني", "probability": 0.853271484375}, {"start": 2144.23, "end": 2144.67, "word": " الفحص", "probability": 0.9659830729166666}, {"start": 2144.67, "end": 2145.37, "word": " الجنيني", "probability": 0.937744140625}, {"start": 2145.37, "end": 2145.75, "word": " أو", "probability": 0.93359375}, {"start": 2145.75, "end": 2146.17, "word": " الفحص", "probability": 0.9352213541666666}, {"start": 2146.17, "end": 2146.77, "word": " الجيني", "probability": 0.9181315104166666}, {"start": 2146.77, "end": 2147.23, "word": " قبل", "probability": 0.987060546875}, {"start": 2147.23, "end": 2147.91, "word": " عملية", "probability": 0.9931640625}, {"start": 2147.91, "end": 2148.67, "word": " ال", "probability": 0.95556640625}, {"start": 2148.67, "end": 2149.37, "word": " implantation", "probability": 0.682373046875}, {"start": 2149.37, "end": 2149.59, "word": " أو", "probability": 0.9501953125}, {"start": 2149.59, "end": 2150.23, "word": " الانغراس", "probability": 0.775732421875}, {"start": 2150.23, "end": 2150.45, "word": " أو", "probability": 0.96533203125}, {"start": 2150.45, "end": 2151.01, "word": " الزراع", "probability": 0.8946533203125}, {"start": 2151.01, "end": 2151.75, "word": " أو", "probability": 0.95458984375}, {"start": 2151.75, "end": 2152.33, "word": " الإعادة", "probability": 0.939208984375}, {"start": 2152.33, "end": 2152.45, "word": " ال", "probability": 0.422607421875}, {"start": 2152.45, "end": 2152.93, "word": " embryo", "probability": 0.528167724609375}, {"start": 2152.93, "end": 2154.43, "word": " هذا", "probability": 0.8359375}, {"start": 2154.43, "end": 2154.85, "word": " مصطلح", "probability": 0.990625}, {"start": 2154.85, "end": 2155.45, "word": " بنسميه", "probability": 0.8802490234375}, {"start": 2155.45, "end": 2155.69, "word": " polar", "probability": 0.7861328125}, {"start": 2155.69, "end": 2156.05, "word": " body", "probability": 0.8466796875}, {"start": 2156.05, "end": 2156.55, "word": " biopsy", "probability": 0.9034830729166666}, {"start": 2156.55, "end": 2157.19, "word": " ممكن", "probability": 0.941162109375}, {"start": 2157.19, "end": 2157.61, "word": " أخد", "probability": 0.83984375}, {"start": 2157.61, "end": 2157.95, "word": " polar", "probability": 0.94482421875}, {"start": 2157.95, "end": 2158.27, "word": " body", "probability": 0.8779296875}, {"start": 2158.27, "end": 2158.67, "word": " biopsy", "probability": 0.912109375}, {"start": 2158.67, "end": 2158.91, "word": " يعني", "probability": 0.881591796875}, {"start": 2158.91, "end": 2159.23, "word": " أخد", "probability": 0.9339192708333334}, {"start": 2159.23, "end": 2159.59, "word": " جزء", "probability": 0.99609375}, {"start": 2159.59, "end": 2159.75, "word": " من", "probability": 0.9951171875}, {"start": 2159.75, "end": 2159.89, "word": " ال", "probability": 0.9306640625}, {"start": 2159.89, "end": 2160.09, "word": " polar", "probability": 0.85009765625}, {"start": 2160.09, "end": 2160.43, "word": " body", "probability": 0.888671875}], "temperature": 1.0}, {"id": 82, "seek": 218873, "start": 2161.35, "end": 2188.73, "text": "و أعمله genetic testing فلازم عشان أصل للـ polar body أعمل opening في الـ zoonableucida لأن أحنا عارفين أن البويضة الملقحة فيها two polar body بتكون ما بين البويضة و ما بين ال zoonableucida فلازم أخترق ال zoonableucida عشان أعمل suction لل polar body تحت مصطلح polar body biopsy ال polar body biopsy كان أول ما تم تكوينه في عام و إنجازه في عام 1990 ال polar body", "tokens": [2407, 5551, 25957, 43761, 12462, 4997, 6156, 1211, 31377, 2304, 6225, 8592, 7649, 5551, 36520, 24976, 39184, 12367, 1772, 5551, 25957, 1211, 5193, 8978, 2423, 39184, 710, 4106, 712, 1311, 2887, 5296, 33456, 5551, 5016, 8315, 6225, 9640, 5172, 9957, 14739, 29739, 45865, 11242, 3660, 9673, 1211, 4587, 5016, 3660, 8978, 11296, 732, 12367, 1772, 39894, 30544, 19446, 49374, 29739, 45865, 11242, 3660, 4032, 19446, 49374, 2423, 710, 4106, 712, 1311, 2887, 6156, 1211, 31377, 2304, 5551, 46456, 2288, 4587, 2423, 710, 4106, 712, 1311, 2887, 6225, 8592, 7649, 5551, 25957, 1211, 40431, 24976, 12367, 1772, 6055, 33753, 3714, 9381, 9566, 1211, 5016, 12367, 1772, 3228, 404, 3187, 2423, 12367, 1772, 3228, 404, 3187, 25961, 5551, 12610, 19446, 46811, 6055, 4117, 2407, 9957, 3224, 8978, 6225, 10943, 4032, 36145, 7435, 31377, 3224, 8978, 6225, 10943, 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{"start": 2174.47, "end": 2175.21, "word": " فلازم", "probability": 0.935302734375}, {"start": 2175.21, "end": 2175.59, "word": " أخترق", "probability": 0.8739013671875}, {"start": 2175.59, "end": 2175.69, "word": " ال", "probability": 0.94580078125}, {"start": 2175.69, "end": 2176.15, "word": " zoonableucida", "probability": 0.93427734375}, {"start": 2176.15, "end": 2176.41, "word": " عشان", "probability": 0.9376627604166666}, {"start": 2176.41, "end": 2176.77, "word": " أعمل", "probability": 0.9903971354166666}, {"start": 2176.77, "end": 2177.29, "word": " suction", "probability": 0.57177734375}, {"start": 2177.29, "end": 2177.83, "word": " لل", "probability": 0.9150390625}, {"start": 2177.83, "end": 2178.09, "word": " polar", "probability": 0.54296875}, {"start": 2178.09, "end": 2178.39, "word": " body", "probability": 0.8642578125}, {"start": 2178.39, "end": 2178.91, "word": " تحت", "probability": 0.980712890625}, {"start": 2178.91, "end": 2179.41, "word": " مصطلح", "probability": 0.99169921875}, {"start": 2179.41, "end": 2180.07, "word": " polar", "probability": 0.82421875}, {"start": 2180.07, "end": 2180.49, "word": " body", "probability": 0.83447265625}, {"start": 2180.49, "end": 2181.33, "word": " biopsy", "probability": 0.9454752604166666}, {"start": 2181.33, "end": 2181.75, "word": " ال", "probability": 0.8056640625}, {"start": 2181.75, "end": 2181.97, "word": " polar", "probability": 0.5361328125}, {"start": 2181.97, "end": 2182.23, "word": " body", "probability": 0.85888671875}, {"start": 2182.23, "end": 2182.79, "word": " biopsy", "probability": 0.9192708333333334}, {"start": 2182.79, "end": 2183.21, "word": " كان", "probability": 0.97607421875}, {"start": 2183.21, "end": 2183.57, "word": " أول", "probability": 0.936767578125}, {"start": 2183.57, "end": 2183.73, "word": " ما", "probability": 0.9638671875}, {"start": 2183.73, "end": 2184.07, "word": " تم", "probability": 0.9931640625}, {"start": 2184.07, "end": 2184.69, "word": " تكوينه", "probability": 0.9666015625}, {"start": 2184.69, "end": 2184.83, "word": " في", "probability": 0.865234375}, {"start": 2184.83, "end": 2185.09, "word": " عام", "probability": 0.9921875}, {"start": 2185.09, "end": 2185.25, "word": " و", "probability": 0.896484375}, {"start": 2185.25, "end": 2185.87, "word": " إنجازه", "probability": 0.887939453125}, {"start": 2185.87, "end": 2185.97, "word": " في", "probability": 0.96826171875}, {"start": 2185.97, "end": 2186.09, "word": " عام", "probability": 0.979248046875}, {"start": 2186.09, "end": 2186.75, "word": " 1990", "probability": 0.8720703125}, {"start": 2186.75, "end": 2188.15, "word": " ال", "probability": 0.78271484375}, {"start": 2188.15, "end": 2188.37, "word": " polar", "probability": 0.93408203125}, {"start": 2188.37, "end": 2188.73, "word": " body", "probability": 0.8759765625}], "temperature": 1.0}, {"id": 83, "seek": 221026, "start": 2189.06, "end": 2210.26, "text": "بيحتوي على المادة الوراثية الخاصة بالأم polar body consists of genetic material related to mother or maternal only خدوا بالكوا من القصة يعنى أي مرض وراثي متعلق بالأم بافحصه من خلال ال polar body أي مرض وراثي متعلق بالجنين بافحصه من خلال ال embryonic cell", "tokens": [21292, 33753, 45865, 15844, 9673, 18513, 3660, 2423, 13063, 5718, 104, 10632, 33962, 33546, 3660, 20666, 10721, 2304, 12367, 1772, 14689, 295, 12462, 2527, 4077, 281, 2895, 420, 37944, 787, 16490, 3215, 14407, 20666, 4117, 14407, 9154, 25062, 9381, 3660, 37495, 1863, 7578, 36632, 3714, 43042, 4032, 2288, 5718, 104, 1829, 44650, 30241, 4587, 20666, 10721, 2304, 4724, 31845, 5016, 9381, 3224, 9154, 16490, 1211, 6027, 2423, 12367, 1772, 36632, 3714, 43042, 4032, 2288, 5718, 104, 1829, 44650, 30241, 4587, 20666, 7435, 1863, 9957, 4724, 31845, 5016, 9381, 3224, 9154, 16490, 1211, 6027, 2423, 31588, 11630, 2815], "avg_logprob": -0.21077806456964843, "compression_ratio": 1.8487804878048781, "no_speech_prob": 4.589557647705078e-06, "words": [{"start": 2189.06, "end": 2189.62, "word": "بيحتوي", "probability": 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related", "probability": 0.9580078125}, {"start": 2195.58, "end": 2195.86, "word": " to", "probability": 0.97607421875}, {"start": 2195.86, "end": 2196.22, "word": " mother", "probability": 0.81640625}, {"start": 2196.22, "end": 2196.96, "word": " or", "probability": 0.88623046875}, {"start": 2196.96, "end": 2197.64, "word": " maternal", "probability": 0.92724609375}, {"start": 2197.64, "end": 2198.32, "word": " only", "probability": 0.896484375}, {"start": 2198.32, "end": 2198.8, "word": " خدوا", "probability": 0.60205078125}, {"start": 2198.8, "end": 2199.1, "word": " بالكوا", "probability": 0.6153971354166666}, {"start": 2199.1, "end": 2199.18, "word": " من", "probability": 0.41064453125}, {"start": 2199.18, "end": 2199.52, "word": " القصة", "probability": 0.9793294270833334}, {"start": 2199.52, "end": 2199.72, "word": " يعنى", "probability": 0.726806640625}, {"start": 2199.72, "end": 2200.4, "word": " أي", "probability": 0.39111328125}, {"start": 2200.4, "end": 2200.76, "word": " 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أي النواء الذكرية النواء الأنثوية اندمجت صار ال fertilization خرج ال second polar body فانا ممكن أسحب هذا ال polar body و ممكن أسحب اتنين مع بعض هذا له وظيفة و هذا له وظيفة", "tokens": [3224, 1829, 2423, 39184, 460, 53, 17349, 23032, 3555, 3615, 995, 29538, 2423, 39184, 44169, 306, 2423, 39184, 2935, 39182, 9957, 20328, 9640, 43242, 7578, 3714, 3224, 26108, 25720, 10874, 11622, 38207, 9154, 33962, 15040, 25528, 34051, 6225, 5172, 14407, 10874, 11622, 38207, 9154, 33251, 2288, 2304, 2407, 11622, 20498, 9307, 30731, 41950, 28480, 33962, 1211, 10632, 16070, 7435, 11622, 38207, 16247, 34740, 6055, 3555, 4587, 7578, 6055, 2407, 22653, 2423, 4865, 372, 12367, 1772, 39182, 2423, 18512, 2144, 36632, 28239, 2407, 16606, 32545, 4117, 16572, 3660, 28239, 2407, 16606, 16247, 1863, 12984, 2407, 10632, 16472, 40448, 7435, 2655, 20328, 9640, 2423, 18512, 2144, 16490, 47341, 2423, 1150, 12367, 1772, 6156, 7649, 995, 3714, 43020, 5551, 3794, 5016, 3555, 23758, 2423, 12367, 1772, 4032, 3714, 43020, 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"end": 2681.84, "word": " حد", "probability": 0.99267578125}, {"start": 2681.84, "end": 2682.12, "word": " ما", "probability": 0.97265625}, {"start": 2682.12, "end": 2683.02, "word": " تقلل", "probability": 0.9141845703125}, {"start": 2683.02, "end": 2683.32, "word": " عدد", "probability": 0.9762369791666666}, {"start": 2683.32, "end": 2683.68, "word": " الخلال", "probability": 0.7776692708333334}, {"start": 2683.68, "end": 2683.94, "word": " التي", "probability": 0.57666015625}, {"start": 2683.94, "end": 2684.4, "word": " تخرج", "probability": 0.99462890625}, {"start": 2684.4, "end": 2684.68, "word": " من", "probability": 0.9951171875}, {"start": 2684.68, "end": 2685.92, "word": " ال", "probability": 0.95751953125}, {"start": 2685.92, "end": 2686.54, "word": " embryo", "probability": 0.5237274169921875}, {"start": 2686.54, "end": 2686.72, "word": " أو", "probability": 0.78369140625}, {"start": 2686.72, "end": 2687.7, "word": " البوايدة", "probability": 0.64990234375}, {"start": 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"word": " body", "probability": 0.90625}, {"start": 2706.39, "end": 2706.67, "word": " و", "probability": 0.60791015625}, {"start": 2706.67, "end": 2706.85, "word": " هذا", "probability": 0.71826171875}, {"start": 2706.85, "end": 2706.97, "word": " ال", "probability": 0.93896484375}, {"start": 2706.97, "end": 2707.19, "word": " first", "probability": 0.89697265625}, {"start": 2707.19, "end": 2707.51, "word": " polar", "probability": 0.953125}, {"start": 2707.51, "end": 2707.77, "word": " body", "probability": 0.89453125}, {"start": 2707.77, "end": 2708.07, "word": " لأن", "probability": 0.83544921875}, {"start": 2708.07, "end": 2708.43, "word": " دائما", "probability": 0.8165690104166666}, {"start": 2708.43, "end": 2708.65, "word": " هذه", "probability": 0.923828125}, {"start": 2708.65, "end": 2709.53, "word": " البوايضة", "probability": 0.977734375}, {"start": 2709.53, "end": 2709.79, "word": " يكون", "probability": 0.614990234375}, {"start": 2709.79, "end": 2709.91, "word": " ال", "probability": 0.94287109375}, {"start": 2709.91, "end": 2710.13, "word": " first", "probability": 0.892578125}, {"start": 2710.13, "end": 2710.45, "word": " polar", "probability": 0.955078125}, {"start": 2710.45, "end": 2710.67, "word": " body", "probability": 0.91748046875}, {"start": 2710.67, "end": 2710.85, "word": " عند", "probability": 0.974609375}, {"start": 2710.85, "end": 2711.13, "word": " الساعة", "probability": 0.9269205729166666}, {"start": 2711.13, "end": 2711.43, "word": " 12", "probability": 0.646484375}, {"start": 2711.43, "end": 2711.63, "word": " for", "probability": 0.6015625}, {"start": 2711.63, "end": 2712.09, "word": " example", "probability": 0.96484375}], "temperature": 1.0}, {"id": 102, "seek": 272565, "start": 2712.47, "end": 2725.65, "text": "و ال second polar body على يمينه دائما بكون على يمينه فبالتالي لما انت تعمل دخول بال aspiration needle او aspiration pipet هتسحب في البداية ال first polar body .. ال second polar body", "tokens": [2407, 2423, 1150, 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2921.39, "word": " التي", "probability": 0.79296875}, {"start": 2921.39, "end": 2922.21, "word": " يمكن", "probability": 0.850830078125}, {"start": 2922.21, "end": 2922.43, "word": " أن", "probability": 0.78564453125}, {"start": 2922.43, "end": 2922.93, "word": " تحدث", "probability": 0.97119140625}, {"start": 2922.93, "end": 2923.79, "word": " فبالتالي", "probability": 0.9698893229166666}, {"start": 2923.79, "end": 2924.21, "word": " من", "probability": 0.97119140625}, {"start": 2924.21, "end": 2924.83, "word": " خلال", "probability": 0.9944661458333334}, {"start": 2924.83, "end": 2925.63, "word": " تقليل", "probability": 0.9869384765625}, {"start": 2925.63, "end": 2925.95, "word": " عدد", "probability": 0.9757486979166666}, {"start": 2925.95, "end": 2926.27, "word": " الخلال", "probability": 0.841796875}, {"start": 2926.27, "end": 2926.47, "word": " التي", "probability": 0.92626953125}, {"start": 2926.47, "end": 2926.83, "word": " يمكن", "probability": 0.945556640625}, {"start": 2926.83, "end": 2926.99, "word": " أن", "probability": 0.74951171875}, {"start": 2926.99, "end": 2927.51, "word": " تخرج", "probability": 0.9742838541666666}, {"start": 2927.51, "end": 2927.85, "word": " مع", "probability": 0.9755859375}, {"start": 2927.85, "end": 2928.43, "word": " ال", "probability": 0.935546875}, {"start": 2928.43, "end": 2928.69, "word": " polar", "probability": 0.74658203125}, {"start": 2928.69, "end": 2929.05, "word": " body", "probability": 0.884765625}, {"start": 2929.05, "end": 2929.33, "word": " مع", "probability": 0.37353515625}, {"start": 2929.33, "end": 2929.71, "word": " ال", "probability": 0.9423828125}, {"start": 2929.71, "end": 2929.97, "word": " polar", "probability": 0.95703125}, {"start": 2929.97, "end": 2930.45, "word": " body", "probability": 0.92578125}, {"start": 2930.45, "end": 2930.87, "word": " هذا", "probability": 0.56689453125}, {"start": 2930.87, "end": 2931.27, "word": " شكل", "probability": 0.9736328125}, {"start": 2931.27, "end": 2931.89, "word": " أخر", "probability": 0.7197265625}, {"start": 2931.89, "end": 2932.11, "word": " من", "probability": 0.99072265625}, {"start": 2932.11, "end": 2932.63, "word": " الأشكال", "probability": 0.9915771484375}, {"start": 2932.63, "end": 2933.55, "word": " الخاصة", "probability": 0.9557291666666666}, {"start": 2933.55, "end": 2934.45, "word": " فيه", "probability": 0.84228515625}, {"start": 2934.45, "end": 2934.75, "word": " طبعا", "probability": 0.86785888671875}, {"start": 2934.75, "end": 2934.95, "word": " هذه", "probability": 0.27294921875}, {"start": 2934.95, "end": 2935.83, "word": " بدخل", "probability": 0.7657877604166666}, {"start": 2935.83, "end": 2936.01, "word": " ب", "probability": 0.332275390625}, {"start": 2936.01, "end": 2936.83, "word": " aspiration", "probability": 0.6455078125}, {"start": 2936.83, "end": 2937.41, "word": " needle", "probability": 0.91748046875}, {"start": 2937.41, "end": 2938.59, "word": " سحب", "probability": 0.796630859375}, {"start": 2938.59, "end": 2939.31, "word": " أو", "probability": 0.71728515625}, {"start": 2939.31, "end": 2939.75, "word": " ثبت", "probability": 0.9781901041666666}, {"start": 2939.75, "end": 2939.89, "word": " ال", "probability": 0.76416015625}, {"start": 2939.89, "end": 2940.13, "word": " first", "probability": 0.89208984375}, {"start": 2940.13, "end": 2940.45, "word": " polar", "probability": 0.9423828125}, {"start": 2940.45, "end": 2940.79, "word": " body", "probability": 0.9052734375}, {"start": 2940.79, "end": 2941.49, "word": " بعدين", "probability": 0.6810302734375}, {"start": 2941.49, "end": 2942.05, "word": " بيسحبوا", "probability": 0.8850911458333334}, {"start": 2942.05, "end": 2942.35, "word": " بهذا", "probability": 0.827880859375}, {"start": 2942.35, "end": 2942.73, "word": " الشكل", "probability": 0.990478515625}, {"start": 2942.73, "end": 2943.41, "word": " سحب", "probability": 0.97607421875}, {"start": 2943.41, "end": 2943.53, "word": " ال", "probability": 0.85693359375}, {"start": 2943.53, "end": 2943.73, "word": " second", "probability": 0.96484375}, {"start": 2943.73, "end": 2944.01, "word": " polar", "probability": 0.9599609375}, {"start": 2944.01, "end": 2944.35, "word": " body", "probability": 0.90673828125}, {"start": 2944.35, "end": 2944.89, "word": " بعدين", "probability": 0.806640625}, {"start": 2944.89, "end": 2945.21, "word": " سحب", "probability": 0.9912109375}, {"start": 2945.21, "end": 2945.29, "word": " ال", "probability": 0.96826171875}, {"start": 2945.29, "end": 2945.51, "word": " first", "probability": 0.91064453125}, {"start": 2945.51, "end": 2945.81, "word": " polar", "probability": 0.94140625}, {"start": 2945.81, "end": 2946.15, "word": " body", "probability": 0.890625}, {"start": 2946.15, "end": 2946.65, "word": " طلع", "probability": 0.7327473958333334}, {"start": 2946.65, "end": 2947.03, "word": " منهم", "probability": 0.97607421875}, {"start": 2947.03, "end": 2947.47, "word": " و", "probability": 0.9453125}, {"start": 2947.47, "end": 2947.89, "word": " أضافهم", "probability": 0.81915283203125}, {"start": 2947.89, "end": 2948.07, "word": " في", "probability": 0.96435546875}, {"start": 2948.07, "end": 2948.57, "word": " منطقة", "probability": 0.9772135416666666}], "temperature": 1.0}, {"id": 110, "seek": 295664, "start": 2948.96, "end": 2956.64, "text": "خالية كدا سنكتفي بهذا القدر في هذه المحاضرة على أمل أن نلتقي في محاضرة قادمة ان شاء الله", "tokens": [9778, 6027, 10632, 9122, 28259, 8608, 1863, 4117, 2655, 41185, 39627, 15730, 25062, 3215, 2288, 8978, 29538, 9673, 5016, 46958, 25720, 15844, 5551, 42213, 14739, 8717, 1211, 2655, 38436, 8978, 3714, 5016, 46958, 25720, 12174, 18513, 46007, 16472, 13412, 16606, 21984], "avg_logprob": -0.08458891120694932, "compression_ratio": 1.4722222222222223, "no_speech_prob": 6.973743438720703e-06, "words": [{"start": 2948.96, "end": 2949.52, "word": "خالية", "probability": 0.7906901041666666}, {"start": 2949.52, "end": 2950.22, "word": " كدا", "probability": 0.665771484375}, {"start": 2950.22, "end": 2951.02, "word": " سنكتفي", "probability": 0.94228515625}, {"start": 2951.02, "end": 2951.38, "word": " بهذا", "probability": 0.956787109375}, {"start": 2951.38, "end": 2951.76, "word": " القدر", "probability": 0.9864908854166666}, {"start": 2951.76, "end": 2951.9, "word": " في", "probability": 0.9619140625}, {"start": 2951.9, "end": 2952.16, "word": " هذه", "probability": 0.9091796875}, {"start": 2952.16, "end": 2952.78, "word": " المحاضرة", "probability": 0.99267578125}, {"start": 2952.78, "end": 2953.24, "word": " على", "probability": 0.8984375}, {"start": 2953.24, "end": 2953.56, "word": " أمل", "probability": 0.906494140625}, {"start": 2953.56, "end": 2953.78, "word": " أن", "probability": 0.7998046875}, {"start": 2953.78, "end": 2954.26, "word": " نلتقي", "probability": 0.9361572265625}, {"start": 2954.26, "end": 2954.42, "word": " في", "probability": 0.96533203125}, {"start": 2954.42, "end": 2954.94, "word": " محاضرة", "probability": 0.9935302734375}, {"start": 2954.94, "end": 2955.58, "word": " قادمة", "probability": 0.9931640625}, {"start": 2955.58, "end": 2956.18, "word": " ان", "probability": 0.78515625}, {"start": 2956.18, "end": 2956.56, "word": " شاء", "probability": 0.97998046875}, {"start": 2956.56, "end": 2956.64, "word": " الله", "probability": 0.92919921875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2957.06125, "duration_after_vad": 2854.3568749999863}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/WkQtL6R0CPk_raw.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/WkQtL6R0CPk_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..bc80863a3e0119bb8f4c95ede517fb2ab8358990
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/WkQtL6R0CPk_raw.srt
@@ -0,0 +1,2652 @@
+1
+00:00:02,600 --> 00:00:06,900
+بسم الله الرحمن الرحيم والصلاة وسلامه على أشرف
+
+2
+00:00:06,900 --> 00:00:12,620
+المرسلين سيدنا محمد وعلى آله وصحبه أجمعين، طلابنا
+
+3
+00:00:12,620 --> 00:00:17,240
+الأفاضل، نرجو من الله أن تكونوا جميعا بخير وبصحة
+
+4
+00:00:17,240 --> 00:00:22,790
+جيدةاستكمالًا لما بدأنا فيه في مساق مواضيع خاصة في
+
+5
+00:00:22,790 --> 00:00:27,190
+العلوم الطبية المخبرية والذي سوف يتناول هذا المساق
+
+6
+00:00:27,190 --> 00:00:31,070
+عملية التلقيح الصناعي أو الحقن المجهري طرقه
+
+7
+00:00:31,070 --> 00:00:36,630
+وأسبابه وأساليبه اليوم سوف نبدأ في chapter جديد
+
+8
+00:00:36,630 --> 00:00:41,610
+وهو ال chapter الثاني والذي سوف يتحدث عن عملية نقل
+
+9
+00:00:41,610 --> 00:00:46,110
+الجامعاتوالجميطات المقصود بها هي عبارة عن النطف
+
+10
+00:00:46,110 --> 00:00:49,250
+الذكالية المتمثلة في الـ spermatozoa والنطف
+
+11
+00:00:49,250 --> 00:00:53,430
+الأنثوية المتمثلة في الـ oocyte كيف يتم نقلها من
+
+12
+00:00:53,430 --> 00:00:56,730
+مكان التصنيع إلى مكان الاستخدام والمقصود
+
+13
+00:00:56,730 --> 00:01:00,490
+بالاستخدام؟ هي عبارة عن منطقة ال fertilization
+
+14
+00:01:00,490 --> 00:01:05,190
+والتي تحدث في ال fallopian tube عند الفيميل مرورا
+
+15
+00:01:05,190 --> 00:01:10,150
+بال fertilizationوانتهاء بمرض يحدث عند السيدات
+
+16
+00:01:10,150 --> 00:01:15,530
+يؤدي إلى عدم إنجاب يسمى Ectopic Epigenesis هذه أهم
+
+17
+00:01:15,530 --> 00:01:20,070
+النقاط اللي احنا هنتكلم فيها خلال هذه المحاضرة
+
+18
+00:01:20,070 --> 00:01:28,130
+وعلى مدار الشبطر هذا بشكل الكامل بداية سوف نتكلم
+
+19
+00:01:28,130 --> 00:01:35,430
+عن ال fertilization ال fertilization كمصطلح يعني
+
+20
+00:01:35,430 --> 00:01:39,780
+الإخصاءيعني طلاق الجامعات الذكرية مع الجامعات
+
+21
+00:01:39,780 --> 00:01:44,640
+الأنثوية في منطقة معينة واندماجهم مع بعضهم البعض،
+
+22
+00:01:44,640 --> 00:01:49,320
+وخاصة في الـ Female Reproductive Track مما يؤدي
+
+23
+00:01:49,320 --> 00:01:54,220
+إلى تكوين خلية تسمى الزيجوت، الزيجوت هي عبارة عن
+
+24
+00:01:54,220 --> 00:01:59,600
+أول خليةتنتج من خلال اندماج الجامعات الذكرية مع
+
+25
+00:01:59,600 --> 00:02:04,200
+الجامعات الأنثوية تحت مصطلح fertilization وعشان
+
+26
+00:02:04,200 --> 00:02:07,820
+أبدأ أحكي عن ال fertilization لازم أبدأ أحكي عن
+
+27
+00:02:07,820 --> 00:02:11,440
+أول حدث بيصير عند ال female وهو عبارة عن ال
+
+28
+00:02:11,440 --> 00:02:16,120
+ovulation فال ovulation كمصطلح يقصد به عملية
+
+29
+00:02:16,120 --> 00:02:21,860
+الإبادةعرفنا إن الفيميل تصل لسنه برشد وهي تملك عدد
+
+30
+00:02:21,860 --> 00:02:27,020
+معين من البويضات يقدر بـ250 ألف بويضة ربع مليون
+
+31
+00:02:27,020 --> 00:02:31,660
+بويضة لا يتم استخدام كل هذه البويضات إنما معظمها
+
+32
+00:02:31,660 --> 00:02:37,400
+يدخل في الاببتوسس تحت مصطلح atresia فبالتالي هناك
+
+33
+00:02:37,400 --> 00:02:41,960
+عدد من البويضات يتم استخدام بشكل شهري في مصطلح ال
+
+34
+00:02:41,960 --> 00:02:46,970
+menstrual cycle بعضهم يخصط ويؤدي لتكوي جنينوالبعض
+
+35
+00:02:46,970 --> 00:02:51,550
+الآخر يخرج مع الدورة الشهرية في عملية ال bleeding
+
+36
+00:02:51,550 --> 00:02:56,870
+وعرفنا أن الدورة الشهرية تتراوح ما بين 28 يوم من
+
+37
+00:02:56,870 --> 00:03:00,850
+البداية حتى النهاية بس كمان بينما كان ال duration
+
+38
+00:03:00,850 --> 00:03:06,190
+مع ال bleeding خمس أيام as average في المتصف
+
+39
+00:03:06,190 --> 00:03:09,250
+الدورة الشهرية at the middle point of menstrual
+
+40
+00:03:09,250 --> 00:03:12,550
+cycle في اليوم ال 13 وال14 بيحدث عملية ال
+
+41
+00:03:12,550 --> 00:03:18,540
+ovulation حيث تتدوروتنضج عدد من الفوليكل تسمى
+
+42
+00:03:18,540 --> 00:03:21,780
+graphian follicle وإذا نضجت تسميها mature graphian
+
+43
+00:03:21,780 --> 00:03:27,040
+follicle تحتوي بداخلها على بوايبة واحدة ناضجة هذه
+
+44
+00:03:27,040 --> 00:03:31,460
+البوايبة الواحدة الناضجة يجب أن تستقر وتدخل في
+
+45
+00:03:31,460 --> 00:03:35,420
+مرحلة arrested stage في مرحلة يسميها Prophase of
+
+46
+00:03:35,420 --> 00:03:39,080
+the fairest meiotic division Prophase of the
+
+47
+00:03:39,080 --> 00:03:42,600
+fairest meiotic division Prophase of the fairest
+
+48
+00:03:42,600 --> 00:03:45,340
+meiotic divisionيعني هذه البوايضة الناضجة عشان
+
+49
+00:03:45,340 --> 00:03:49,960
+أقول إنها ناضجة و Graphian فولكيل ناضجة لازم هذه
+
+50
+00:03:49,960 --> 00:03:54,520
+الفولكيل تحتوي على بوايضة داخلها في مرحلة arrested
+
+51
+00:03:54,520 --> 00:03:58,900
+في الإنقسام الميوزي الأول في أي طور من انقسام
+
+52
+00:03:58,900 --> 00:04:02,900
+الميوزي الأول لـProphase في هذه اللحظة تبدأ
+
+53
+00:04:02,900 --> 00:04:08,930
+البوايضة تظهر على سطح الـovaryبعد كده الميويدا
+
+54
+00:04:08,930 --> 00:04:11,730
+لازم تستجيب لبعض الهرمونات أشهرها الـ Follicle
+
+55
+00:04:11,730 --> 00:04:15,210
+Stimulating Hormone و الـ Lactalizing Hormone اللي
+
+56
+00:04:15,210 --> 00:04:20,150
+بيعملوا عملية أطور و نضوج دراماتيكي للميويدا عشان
+
+57
+00:04:20,150 --> 00:04:24,190
+تصل للدياميتر المطلوب و لعدد الكروموزومات المطلوبة
+
+58
+00:04:24,190 --> 00:04:29,170
+The first meiotic division will be completely then
+
+59
+00:04:29,170 --> 00:04:32,590
+the second meiotic division will be start until
+
+60
+00:04:32,590 --> 00:04:36,560
+metaphysic stage يعني وصلت الفولكلالـ Graphin
+
+61
+00:04:36,560 --> 00:04:43,440
+follicle لحد النضوج هيكتمل انقسام الميوزي الأول ثم
+
+62
+00:04:43,440 --> 00:04:48,060
+تبدأ البوايضة في الدخول في انقسام الميوزي الثاني
+
+63
+00:04:48,060 --> 00:04:53,180
+وتستقر في الـ Metaphyse من أشهر ال marker الخاصة
+
+64
+00:04:53,180 --> 00:04:56,160
+باستقرارها في ال Metaphyse ظهور ما يُعرف اسم
+
+65
+00:04:56,160 --> 00:05:00,000
+الferrous polar body وعارفين أن الferrous polar
+
+66
+00:05:00,000 --> 00:05:04,740
+body عبارة عن جزء من الكروموزومات بعد عملية انقسام
+
+67
+00:05:04,740 --> 00:05:08,930
+السيتوبلازميولأ، بيتودّي لتكوين خلية هذه الخلية
+
+68
+00:05:08,930 --> 00:05:12,810
+تحتوي على كمية قالية جدا من الـcytoplasm لا تكفي
+
+69
+00:05:12,810 --> 00:05:16,190
+للاستقرار أو للبقاء أو لاستمرار عملية الانقسام
+
+70
+00:05:16,190 --> 00:05:20,310
+فبسميها The rest polar body وقوف الخلية أو
+
+71
+00:05:20,310 --> 00:05:23,450
+البوايبة عند الـmetaphase الخاص بالانقسام الميوزي
+
+72
+00:05:23,450 --> 00:05:28,310
+الثاني دليل على نضوجها وقدرتنا على استخدامها في
+
+73
+00:05:28,310 --> 00:05:33,320
+عملية ال fertilization يعني بمعنى أخرلا يمكن تلقيح
+
+74
+00:05:33,320 --> 00:05:39,280
+أي بويضة إلا عند وقوفة في الmetaphase stage الخاص
+
+75
+00:05:39,280 --> 00:05:44,160
+بالقسام الميوزي الثاني يعني بويضة زائد first polar
+
+76
+00:05:44,160 --> 00:05:48,240
+body ساعتها بقول والله دي البويضة أستطيع أن أدخلها
+
+77
+00:05:48,240 --> 00:05:56,280
+في عملية التلقيح الصناعي أو الحقن المجهد after
+
+78
+00:05:56,280 --> 00:05:58,920
+the first meiotic division, the first polar body
+
+79
+00:05:58,920 --> 00:06:08,430
+will be appearedهذا هو المقارنة لإنه ينقص
+
+80
+00:06:08,430 --> 00:06:12,230
+الميوزي الأول ودخلت في انقصام الميوزي الثاني
+
+81
+00:06:12,230 --> 00:06:16,450
+استعدادا لعملية البرتاليزيشن الـ Stimulus for
+
+82
+00:06:16,450 --> 00:06:22,470
+ovulation is the wave or surge of LH secreted by
+
+83
+00:06:22,470 --> 00:06:25,390
+anterior loboparticular gland in the middle point
+
+84
+00:06:25,390 --> 00:06:31,580
+of menstrual cycleيعني نقطة التحفيز الخاصة بعملية
+
+85
+00:06:31,580 --> 00:06:36,560
+الإبادة تنتج وتحدث بفعل إفراز كميات هائلة من
+
+86
+00:06:36,560 --> 00:06:39,880
+الـUtilizing hormone تُعرف باسم الـH-wave يعني
+
+87
+00:06:39,880 --> 00:06:44,380
+الموجة الخاصة بالـH والذي يُفرز كما أسلبنا من
+
+88
+00:06:44,380 --> 00:06:47,740
+الـAnterior Loop of Bacterial Glan في منتصف الدورة
+
+89
+00:06:47,740 --> 00:06:49,460
+الشغرية اليوم 13 أو 14
+
+90
+00:07:00,060 --> 00:07:06,640
+بمجرد إفراز كميات مهولة من الـLH يتم بدرجة و بوقت
+
+91
+00:07:06,640 --> 00:07:11,140
+قصير جدا بعد هذه العملية، بعد إفراز الـLH بكمية من
+
+92
+00:07:11,140 --> 00:07:15,460
+الوقت قليلة جدا تضفق و زيادة تضفق الدم بكمية كبيرة
+
+93
+00:07:15,460 --> 00:07:18,880
+جدا إلى الـouter layer الخاصة بالـfollicular wall
+
+94
+00:07:18,880 --> 00:07:24,360
+اللي بحتوي على جوايدة نادجةمع زيادة تضافق الدم
+
+95
+00:07:24,360 --> 00:07:30,240
+بيصير leakage تسريب لبلازمال بروتين into the
+
+96
+00:07:30,240 --> 00:07:34,540
+tissue through post capillary venules مما يؤدي إلى
+
+97
+00:07:34,540 --> 00:07:38,520
+تكوين ما يُعرف باسم local godiva يعني كام إفراز
+
+98
+00:07:38,520 --> 00:07:42,420
+كمية هائلة من ال utilizing hormone في منتصف الدورة
+
+99
+00:07:42,420 --> 00:07:47,040
+الخاصة في الأنثى يليه مباشرة بكمية قليلة جدا من
+
+100
+00:07:47,040 --> 00:07:53,470
+الوقتبإفراز كمية كبيرة و اتضافة كمية كبيرة جدا من
+
+101
+00:07:53,470 --> 00:07:58,230
+الدم لهذا المكان يليه إفراز كمية هائلة و تثيرية
+
+102
+00:07:58,230 --> 00:08:01,150
+كمية هائلة من الـ plasma protein في ال tissue عن
+
+103
+00:08:01,150 --> 00:08:06,310
+طريق الـ post capillary venules مما يؤدي إلى تدوين
+
+104
+00:08:06,310 --> 00:08:12,730
+local oedema المقصود بالـ local oedema هي عبارة عن
+
+105
+00:08:12,730 --> 00:08:16,750
+إفراز كمية كبيرة جدا من الـ fluid so the oedema
+
+106
+00:08:16,750 --> 00:08:21,360
+and the releasing of certainLogically, activity
+
+107
+00:08:21,360 --> 00:08:24,160
+compounds such as prostaglandin, histamine,
+
+108
+00:08:24,300 --> 00:08:28,640
+vasopressin, plasmin and G-activator will provide
+
+109
+00:08:28,640 --> 00:08:31,660
+a starting point for a series of reactions that
+
+110
+00:08:31,660 --> 00:08:34,900
+result in the local production of a matrix
+
+111
+00:08:34,900 --> 00:08:39,080
+metalloproteinase family of lytic enzymes that
+
+112
+00:08:39,080 --> 00:08:42,520
+degrade a compound of the extracellular matrix
+
+113
+00:08:42,520 --> 00:08:48,770
+يعني انتظروا قمية كبيرة جدا من bloodبالإضافة إلى
+
+114
+00:08:48,770 --> 00:08:52,010
+الـ Leakage الخاص بالـ Plasma Protein وحدوث الـ
+
+115
+00:08:52,010 --> 00:08:56,310
+Local Podema يتبعوا مباشرة إفراز كميات كبيرة جدا
+
+116
+00:08:56,310 --> 00:08:59,690
+من الـ Active Compound على ربطها الـ Prostaglandin
+
+117
+00:08:59,690 --> 00:09:05,710
+يليها الهيستامين ثم نفرطفازوبريسين ثم الـ
+
+118
+00:09:05,710 --> 00:09:09,670
+Plasminogen Activator هذه كلها عبارة عن مواد كيمية
+
+119
+00:09:09,670 --> 00:09:14,670
+تشبه إلى حد ما الـ Hormone Action تساعد في عملية
+
+120
+00:09:14,670 --> 00:09:18,140
+الـ Ovulation كيف تساعد في عملية الـ Ovulation؟من
+
+121
+00:09:18,140 --> 00:09:25,020
+خلال إفراز والمساعدة في عمل series or serial of
+
+122
+00:09:25,020 --> 00:09:29,760
+reaction هذه ال reaction like reaction cascade هذه
+
+123
+00:09:29,760 --> 00:09:34,800
+ال reaction بتعمل على إفراز كمية من matrix
+
+124
+00:09:34,800 --> 00:09:40,080
+metalloproteinase family which working as lytic
+
+125
+00:09:40,080 --> 00:09:44,890
+enzyme هذه ال metalloproteinase family بتشتغلعلى
+
+126
+00:09:44,890 --> 00:09:49,710
+شكل Lithic Enzyme يعني إنزيمات محللة مما يعمل
+
+127
+00:09:49,710 --> 00:09:53,630
+ويؤدي إلى تحليل الخلايا الخارجية للـ Gravian
+
+128
+00:09:53,630 --> 00:09:58,930
+Follicle والسماح بالوايضة الناضجة بالخروج هذه فكرة
+
+129
+00:09:58,930 --> 00:10:02,930
+ال ovulation at that same time في نفس الوقت اللي
+
+130
+00:10:02,930 --> 00:10:06,390
+بتتم فيها إفراز الكملها إن ال active compound
+
+131
+00:10:06,390 --> 00:10:11,300
+بالإضافة إلى ال lithic enzymeيتم إفراز مُركّب آخر،
+
+132
+00:10:11,300 --> 00:10:15,960
+هو عبارة عن الهيالو يورينك أسد، هذا الهيالو يورينك
+
+133
+00:10:15,960 --> 00:10:20,500
+أسد by cell of the humerus، results in losing of
+
+134
+00:10:20,500 --> 00:10:25,600
+the cell surrounding the egg، بمعنى آخرمرافق
+
+135
+00:10:25,600 --> 00:10:32,040
+للأحداث السابقة يفرز مادة تسمى Hyaluronic Acid عن
+
+136
+00:10:32,040 --> 00:10:35,740
+طريق خلايا by the cell of the cumulus عن طريق
+
+137
+00:10:35,740 --> 00:10:39,460
+خلايا تسمى cumulus cells هذه الخلايا أو هذه المادة
+
+138
+00:10:39,460 --> 00:10:44,100
+اللي وفرزت تسمح بتحلل وتفكك الخلايا المحيطة
+
+139
+00:10:44,100 --> 00:10:48,880
+بالبوايدة علشان تكون البوايدة سهلة الانتقال سهلة
+
+140
+00:10:48,880 --> 00:10:53,240
+الخروج سهلة التخصيب لأنه ليس منطق البوايدة تخرج
+
+141
+00:10:53,450 --> 00:10:58,310
+ويكون محيطها كمية كبيرة وهائلة جدا من الخلايا الـ
+
+142
+00:10:58,310 --> 00:11:02,630
+lytic action of matrix metalloproteinase produce
+
+143
+00:11:02,630 --> 00:11:06,570
+an inflammatory-like reaction يعني هذه الكمية
+
+144
+00:11:06,570 --> 00:11:10,910
+المهولة من الـ lytic action بفعل إفراز ال matrix
+
+145
+00:11:10,910 --> 00:11:15,150
+من الـ metalloproteinase reaction أو الـ material
+
+146
+00:11:15,150 --> 00:11:20,230
+أو الـ enzyme بتعمل عمل الـ inflammatory substance
+
+147
+00:11:20,920 --> 00:11:23,800
+شو يعني إذا بيصير عندى inflammatory؟ أول علامات ال
+
+148
+00:11:23,800 --> 00:11:29,260
+inflammation عارفين swelling, fever, redness و ال
+
+149
+00:11:29,260 --> 00:11:32,740
+redness معناها زيادة تضافة الدم في المنطقة اللي
+
+150
+00:11:32,740 --> 00:11:35,680
+صار فيها ال inflammation أو اللي وصل إليها العواب
+
+151
+00:11:35,680 --> 00:11:39,240
+اللي بتعمل inflammation فإنه يشتغل ال matrix
+
+152
+00:11:39,240 --> 00:11:43,540
+metalloproteinase as inflammatory reaction هذا مهم
+
+153
+00:11:43,540 --> 00:11:48,610
+جدا و بيساعد بشكل كبير جدا على حدوث raptureللـ
+
+154
+00:11:48,610 --> 00:11:52,950
+outer layer أو الـ outer wall الخاص بالـ Gravian
+
+155
+00:11:52,950 --> 00:11:59,410
+Follicle مما يسمح بخروج الجوادة طبعا مات بيصير و
+
+156
+00:11:59,410 --> 00:12:02,590
+مات بيفرز و مات بيصير ال rupture و مات بيصير ال
+
+157
+00:12:02,590 --> 00:12:06,970
+ovulation بعد خروج ال utilizing hormone و وصوله
+
+158
+00:12:06,970 --> 00:12:13,990
+إلى أعلى بيه بمعدل 28 إلى 36 ساعة يعني لو السيدة
+
+159
+00:12:13,990 --> 00:12:19,350
+عملت تحليلللـ LH و جالت و الله او وجدت ان الـ LH
+
+160
+00:12:19,350 --> 00:12:25,410
+وصل لأعلى بيك الساعة واحدة صباق غبران مثلا عدت 28
+
+161
+00:12:25,410 --> 00:12:29,730
+ساعة على الأقل بعدين هيبدأ عملية ال ovulation و
+
+162
+00:12:29,730 --> 00:12:33,450
+البويضة تخرج من ال graphian follicle و تصل لل
+
+163
+00:12:33,450 --> 00:12:39,030
+fallopian tube هذه الأعمال او الأحداث اللي بتصير
+
+164
+00:12:39,030 --> 00:12:42,990
+بشكل متتالي و بشكل متتابع علشان الصناعين دي
+
+165
+00:12:42,990 --> 00:12:48,950
+ovulationالـ ovulation result هو عبارة عن انفجار
+
+166
+00:12:48,950 --> 00:12:53,290
+للـ anterior follicle and the ovum from the ovary
+
+167
+00:12:53,290 --> 00:12:58,890
+into the .. into the special cavity located in the
+
+168
+00:12:58,890 --> 00:13:02,810
+ovary .. located in the ovary الـ ovum is not
+
+169
+00:13:02,810 --> 00:13:08,930
+ovulated as single نقت سلقط as complex هذه
+
+170
+00:13:08,930 --> 00:13:12,830
+البوايضة اللي تطلع من الجرافيا للفوليكل بفعل حدوث
+
+171
+00:13:12,830 --> 00:13:17,130
+rupture في الحُد بالذباب قدوس rupture في الـ
+
+172
+00:13:17,130 --> 00:13:23,070
+anterior الـ anterior fluid and ovum ما بتخرج هذه
+
+173
+00:13:23,070 --> 00:13:28,210
+الويدا بشكل نكت يعني عارية من الخلايا لأ ما بتخرج
+
+174
+00:13:28,210 --> 00:13:33,030
+single لوحدها لأ بتخرج محاطة بكمية من الخلايا تعرض
+
+175
+00:13:33,030 --> 00:13:38,830
+كالتالي تخرج عبارة عن ovum زونابليوسيدا وهي عبارة
+
+176
+00:13:38,830 --> 00:13:44,450
+عن cell membrane as word2 أو 3 ملعقة من الكورونا
+
+177
+00:13:44,450 --> 00:13:52,010
+ردياتا و الـ «ماتريكس» يحتوي على «سلب الكيومولاس»
+
+178
+00:13:52,010 --> 00:13:56,770
+يعني عندي في المنتصف الـ ovum البويضة الناضجة التي
+
+179
+00:13:56,770 --> 00:14:01,310
+تلقح يليها مباشرة من الخارج الـ zoonopelucida التي
+
+180
+00:14:01,310 --> 00:14:05,850
+تعمل كـ cell membrane يليها طبقتين أو تلت طبقات من
+
+181
+00:14:05,850 --> 00:14:12,130
+الكورونا ردياتاجاليها طبقة سميكة من الـ cell أو
+
+182
+00:14:12,130 --> 00:14:15,930
+الـ cumulus وهذا الـ cumulus مهم جدًا نتخلص منها
+
+183
+00:14:15,930 --> 00:14:21,790
+قبل عملية ال fertilization مهم جدًا نفهم أن بعض
+
+184
+00:14:21,790 --> 00:14:25,810
+السيدات وبعض الحالات أثناء عملية ال rupture أو ال
+
+185
+00:14:25,810 --> 00:14:29,590
+ovulation بيصير عند السيدة bleeding وهذا أمر طبيعي
+
+186
+00:14:29,590 --> 00:14:34,210
+جدًا ال bleeding مااتش عن تفجر ال follicular الـ
+
+187
+00:14:34,210 --> 00:14:37,010
+graphial follicle أو تفجر ال follicle وخروج
+
+188
+00:14:37,010 --> 00:14:41,110
+البوادةفما في عند منه خوف طالما كان slightly بينما
+
+189
+00:14:41,110 --> 00:14:45,310
+إذا كان heavy و continuously هنا مشكلة لازم يصير
+
+190
+00:14:45,310 --> 00:14:51,150
+فيها زيارة لطبي طبعا يرافقها ألم مستمر في منطقة ال
+
+191
+00:14:51,150 --> 00:14:55,110
+ovary خلينا نشوف الفيديو المتعلق بهذا الموضوع إيش
+
+192
+00:14:55,110 --> 00:14:59,290
+فيحكي على عملية ال ovulation و كيف تتم عملية ال
+
+193
+00:14:59,290 --> 00:15:03,550
+ovulation Structure
+
+194
+00:15:03,550 --> 00:15:04,490
+of Open Ovary
+
+195
+00:15:09,460 --> 00:15:13,540
+الـ ovum هو الوضع الوطني المدرسي اللي يتطور من جرم
+
+196
+00:15:13,540 --> 00:15:17,940
+البراميض الجرمية اللي مجلده في كورتكس العضلات كل
+
+197
+00:15:17,940 --> 00:15:23,100
+جرم البراميض الجرمية يتطور إلى عدد صغير من الجرم
+
+198
+00:15:23,100 --> 00:15:33,240
+يسمى أوغانيا من خلال تقليدات مستمرة وتطور أوغانيا
+
+199
+00:15:33,240 --> 00:15:36,940
+تتطور إلى موقعات استخدام أساسية ومن ثم إلى عضلات
+
+200
+00:15:36,940 --> 00:15:37,320
+مدرسة
+
+201
+00:15:40,850 --> 00:15:43,390
+هل كنت تعرف أن أولاد الحيوانات أو الحيوانات من
+
+202
+00:15:43,390 --> 00:15:49,030
+الحيوانات يمكنها أن تنزل إلى شخص جديد بداخل فترة
+
+203
+00:15:49,030 --> 00:15:52,910
+قصيرة من الأيام أو الأيام أو الأسابق؟ هل هذا لا
+
+204
+00:15:52,910 --> 00:15:57,990
+يجعل الحيوانات حقيقية مميزة في الحيوانات؟ هيا،
+
+205
+00:15:57,990 --> 00:16:01,370
+دعنا نتعرف أكتر عن أسلوب هذه الحيوانات المميزة
+
+206
+00:16:03,920 --> 00:16:08,120
+طبعا في الشق الأول اتكلم عن ال Ogonia وكيف تتطور
+
+207
+00:16:08,120 --> 00:16:12,100
+البويضات من البداية وصولا إلى ال Oocyte حاليا
+
+208
+00:16:12,100 --> 00:16:16,300
+هيتكلم عن ال structure of ovum or oocyte at the
+
+209
+00:16:16,300 --> 00:16:19,760
+end of this module you will be able to describe
+
+210
+00:16:19,760 --> 00:16:25,480
+the structure of a mature ovum structure of an
+
+211
+00:16:25,480 --> 00:16:30,460
+ovum the ovum of humans are spherical about 0.2
+
+212
+00:16:30,460 --> 00:16:35,240
+millimeters in diameterهي وجدتها مغلقه في أعضاء
+
+213
+00:16:35,240 --> 00:16:41,900
+الأعضاء عادة موجوده واحدة من الأعضاء في أعضاء
+
+214
+00:16:41,900 --> 00:16:45,140
+واحدة
+
+215
+00:16:45,140 --> 00:16:46,460
+من الأعضاء موجوده واحدة من الأعضاء موجوده واحدة من
+
+216
+00:16:46,460 --> 00:16:46,460
+الأعضاء موجوده واحدة من الأعضاء موجوده واحدة من
+
+217
+00:16:46,460 --> 00:16:46,500
+الأعضاء موجوده واحدة من الأعضاء موجوده واحدة من
+
+218
+00:16:46,500 --> 00:16:47,320
+الأعضاء موجوده واحدة من الأعضاء موجوده واحدة من
+
+219
+00:16:47,320 --> 00:16:47,320
+الأعضاء موجوده واحدة من الأعضاء موجوده واحدة من
+
+220
+00:16:47,320 --> 00:16:47,480
+الأعضاء موجوده واحدة من الأعضاء موجوده واحدة من
+
+221
+00:16:47,480 --> 00:16:50,900
+الأعضاء موجوده واحدة من الأعضاء موجوده واحد من
+
+222
+00:16:50,900 --> 00:17:00,500
+الأعضاء موجوده واحد
+
+223
+00:17:00,500 --> 00:17:05,980
+من الأعإذن الـ cytoplasm الخاص بالـ Oocyte أو الـ
+
+224
+00:17:05,980 --> 00:17:11,120
+Ovum بسمي O-plasm O-plasm، plasma من الـ plasma و
+
+225
+00:17:11,120 --> 00:17:15,560
+O من ال Oocyte أو ال Ovum فبسميه O-plasm الـ
+
+226
+00:17:15,560 --> 00:17:19,120
+vesicle and the nucleolus is known as the germinal
+
+227
+00:17:19,120 --> 00:17:23,940
+spot a thick transparent envelope covering the
+
+228
+00:17:23,940 --> 00:17:28,620
+ovum is called zona striata or zona pellucida
+
+229
+00:17:29,710 --> 00:17:34,810
+والعضلات العضلية التي تتجارب من الفوليقل إلى الجسم
+
+230
+00:17:34,810 --> 00:17:40,270
+الخارجي تسمى كورونا رادياتر دعونا نعرف أكتر عن
+
+231
+00:17:40,270 --> 00:17:44,870
+الجزءين المختلفة من الـ ovum يلك
+
+232
+00:17:44,870 --> 00:17:50,530
+أو أوفم الوحوش من أوفم يمكن أن يكون مختلفاة إلى
+
+233
+00:17:50,530 --> 00:17:55,250
+اكسوبلزم مظهر خارجي ايضا يسمى البرتقال الأجهزي
+
+234
+00:17:55,250 --> 00:17:59,250
+واندوبلزم مظهر خارجي ايضا يسمى أوفم
+
+235
+00:18:25,380 --> 00:18:28,620
+طبعا هذه التفاصيل اللي بيحكيها كلها مش مهتمين فيها
+
+236
+00:18:28,620 --> 00:18:34,590
+بشكل أساسي ولكن مهتمين مما تتكون ال organالجسم
+
+237
+00:18:34,590 --> 00:18:38,310
+البشري ليس لديه الكثير من هذا اليوك المدعوم الذي
+
+238
+00:18:38,310 --> 00:18:45,870
+يدفع الجسم بسرعة في تطوره، لذلك الجسم البشري يسمى
+
+239
+00:18:45,870 --> 00:18:50,550
+كـ Microlacetal لأن Microlacetal هو كلمة استخدامها
+
+240
+00:18:50,550 --> 00:18:55,490
+لتسمية أشجار صغيرة ليس لديها الكثير من اليوك جرمين
+
+241
+00:18:55,490 --> 00:19:02,100
+الوثيقل الجسم يسمى جرمين الوثيقلالجرمن البسيكل هو
+
+242
+00:19:02,100 --> 00:19:07,500
+كبير ومسلح وفي البداية يحتوي على موقع أساسي ولكن
+
+243
+00:19:07,500 --> 00:19:11,080
+عندما يتكبر الـ ovum فهو يصبح أكسنترك في الموقع،
+
+244
+00:19:11,080 --> 00:19:15,640
+فالطفل الشخصي يحتوي على مقاومة بولارية. جزء من الـ
+
+245
+00:19:15,640 --> 00:19:21,240
+ovum مع جسمه وجسمه بولاري يسمى بـ Animal Pole وجزء
+
+246
+00:19:21,240 --> 00:19:27,540
+أخر يسمى بـ Vegetable Pole. جسم جسم الـ ovum هو
+
+247
+00:19:27,540 --> 00:19:31,370
+نفس ما يكون من جسم عضويةوهي مقفلة في محطة
+
+248
+00:19:31,370 --> 00:19:37,850
+نوكليالية وداخل النوكليس يوجد نوكليوليس مفهوم كما
+
+249
+00:19:37,850 --> 00:19:44,530
+يسمى كـ Germinal Spot مقفلات المطبخ مقفلة ضخمة
+
+250
+00:19:44,530 --> 00:19:49,970
+يسمى Zona striata أو Zona pellucida مقفلة المطبخ
+
+251
+00:19:49,970 --> 00:19:54,830
+لوقت طويل من وقت الترتيب هذه المطبخة قد تساعد في
+
+252
+00:19:54,830 --> 00:20:00,220
+الحماية في أول مرات من الانتقالالـ Corona Radiator
+
+253
+00:20:00,220 --> 00:20:04,420
+هو مجلد من 2 أو 3 مجلد من الأجسام التي تم تجريبها
+
+254
+00:20:04,420 --> 00:20:08,940
+من الفوليكولات هذه الأجسام تتجه إلى الوضع الخارق
+
+255
+00:20:08,940 --> 00:20:15,880
+من الـ Zona pellucida عند إطلاقها من الفوليكولات
+
+256
+00:20:15,880 --> 00:20:20,240
+أجسام الـ Corona Radiator تم تجريبها من حول الـ
+
+257
+00:20:20,240 --> 00:20:24,100
+Zona pellucida والأجسام الأعلى من هذه المجلدة هي
+
+258
+00:20:24,100 --> 00:20:25,680
+كولومنار في شكل
+
+259
+00:20:28,620 --> 00:20:32,720
+طبعا هذه أهم المعلومات الخاصة بالـ Ovum الـ
+
+260
+00:20:32,720 --> 00:20:36,740
+Structure و الـ Ovum بهمن منها الـ Zoonableucida و
+
+261
+00:20:36,740 --> 00:20:38,980
+الـ Function اللي خاصة فيها وهذا هنتكلم فيها
+
+262
+00:20:38,980 --> 00:20:43,960
+باستفادة في محاضرات لاحقة ثم يليها الـ two أو
+
+263
+00:20:43,960 --> 00:20:48,400
+three layer من الـ corona radiata ثم يليها الcell
+
+264
+00:20:48,400 --> 00:20:51,480
+cumulus أو الـ cell cumulus cell المهم جدا في
+
+265
+00:20:51,480 --> 00:20:56,480
+عملية الحماية في عملية الحماية هذه أهم مركبات
+
+266
+00:20:57,440 --> 00:21:03,540
+الخاصة بالـ oven ننتقل فيما بعد إلى كيف تنقل
+
+267
+00:21:03,540 --> 00:21:07,900
+البويضة كيف تنقل البويضة تحت مصطلح oven transport
+
+268
+00:21:07,900 --> 00:21:13,400
+or egg transport the first step in egg transport
+
+269
+00:21:13,400 --> 00:21:18,300
+is capture of the ovulated egg by the tube urinary
+
+270
+00:21:18,300 --> 00:21:21,980
+tube بمعنى
+
+271
+00:21:21,980 --> 00:21:26,840
+آخر انهبمجرد خروج البوايدة من الـ follicle أو من
+
+272
+00:21:26,840 --> 00:21:30,820
+الـ griffian follicle، لازم شعيرات موجودة في نهاية
+
+273
+00:21:30,820 --> 00:21:33,800
+الـ fallopian tube تعمل catching للبوايدة،
+
+274
+00:21:33,800 --> 00:21:38,380
+capturing، capture or catching shortly before
+
+275
+00:21:38,380 --> 00:21:42,820
+ovulation, the bithelium cell of the uterine tube
+
+276
+00:21:42,820 --> 00:21:47,020
+become more highly ciliated and smooth muscles
+
+277
+00:21:47,020 --> 00:21:52,040
+activity in the tube and isLigament increase as
+
+278
+00:21:52,040 --> 00:21:55,620
+the result of hormone influx بمعنى آخر إن هذه
+
+279
+00:21:55,620 --> 00:22:00,220
+العملية لازم تكون عملية متناسقة بمجرد ما البويضة
+
+280
+00:22:00,220 --> 00:22:04,220
+تصل لمرحلة ال population لازم الهرمونات تأثر على
+
+281
+00:22:04,220 --> 00:22:08,000
+ال fallopian tube وعلى ال filament و ال ligament
+
+282
+00:22:08,000 --> 00:22:12,120
+الموجودة في نهاية ال fallopian tube عشان تصير more
+
+283
+00:22:12,120 --> 00:22:16,800
+ciliated مما يساعد على حركة البويضة للداخلو more
+
+284
+00:22:16,800 --> 00:22:20,360
+flexible علشان تقدر تصل للبوايدة في المكان اللي
+
+285
+00:22:20,360 --> 00:22:24,760
+بده تخرج منه بمجرد خروج البوايدة بتعمل catching
+
+286
+00:22:24,760 --> 00:22:28,740
+هذه ال filament أو هذه ال ligament لهذه البوايدة و
+
+287
+00:22:28,740 --> 00:22:32,140
+بتحركها في اتجاه الداخل طب إيش اللي بيخلي ال
+
+288
+00:22:32,140 --> 00:22:36,240
+ligament more flexible و more ciliated؟ و إيش اللي
+
+289
+00:22:36,240 --> 00:22:38,440
+بيخلي ال smooth muscles الخاصة في ال fallopian
+
+290
+00:22:38,440 --> 00:22:41,860
+tube more active؟ هي عبارة عن ال hormones اللي
+
+291
+00:22:41,860 --> 00:22:45,330
+تفرز من خلال ال anterior pateata الجلاندبالإضافة
+
+292
+00:22:45,330 --> 00:22:48,630
+إلى الهرمونات التي تفرز من خلال الـ ovary زي الـ
+
+293
+00:22:48,630 --> 00:22:55,970
+Estrogen ثم البيض سيترانسفورت اتجاه اليوترات
+
+294
+00:22:55,970 --> 00:23:01,570
+أخيرًا بسبب التقلق من عضلات الثموس من جزء من جزء
+
+295
+00:23:01,570 --> 00:23:01,850
+من الجزء من الجزء من الجزء من الجزء من الجزء من
+
+296
+00:23:01,850 --> 00:23:02,370
+الجزء من الجزء من الجزء من الجزء من الجزء من الجزء
+
+297
+00:23:02,370 --> 00:23:07,210
+من الجزء من الجزء من الجزء من الجزء من الجزء من
+
+298
+00:23:07,210 --> 00:23:07,430
+الجزء من الجزء من الجزء من الجزء من الجزء من الجزء
+
+299
+00:23:07,430 --> 00:23:07,450
+من الجزء من الجزء من الجزء من الجزء من الجزء من
+
+300
+00:23:07,450 --> 00:23:07,470
+الجزء من الجزء من الجزء من الجزء من الجزء من الجزء
+
+301
+00:23:07,470 --> 00:23:11,090
+من الجزء من
+
+302
+00:23:11,090 --> 00:23:14,590
+الجزء منمن خلال .. أو عفوًا إلى الرحم من خلال
+
+303
+00:23:14,590 --> 00:23:18,130
+Fallopian Tube ويتم نقلة من خلال Contraction
+
+304
+00:23:18,130 --> 00:23:20,850
+Muscles الخاصة في الـ Fallopian Tube بالإضافة إلى
+
+305
+00:23:20,850 --> 00:23:24,370
+السيريا الموجودة في الداخل وحنشوفها كمان شوية
+
+306
+00:23:24,370 --> 00:23:29,250
+بولّت معلومة جانبية أن الـ Fallopian Tube أو هذه
+
+307
+00:23:29,250 --> 00:23:34,090
+الـ Tube الموجودة في المبيض لأن المبيض هو عبارة عن
+
+308
+00:23:34,090 --> 00:23:38,630
+الـ Ovary الـ Fallopian Tube و الرحم وخلاف وانا
+
+309
+00:23:38,630 --> 00:23:42,110
+كله reproductive systemالمبيع هو المنطقة اللي
+
+310
+00:23:42,110 --> 00:23:46,270
+بيصير فيها مضوج للبويضة، يليها Fallopian Tube اللي
+
+311
+00:23:46,270 --> 00:23:50,050
+بتنقل البويضة بعد ال maturation و ال ovulation إلى
+
+312
+00:23:50,050 --> 00:23:55,330
+الرحل هذه ال tubes بتكون celiated من الداخل، بتكون
+
+313
+00:23:55,330 --> 00:24:01,290
+مبطنة بسيلية من الداخل، like the tubule mucosa may
+
+314
+00:24:01,290 --> 00:24:04,650
+also play a role in the egg transportation، their
+
+315
+00:24:04,650 --> 00:24:08,110
+action is not obligatorybecause women with
+
+316
+00:24:08,110 --> 00:24:13,410
+immutility cilia syndrome are often fertile وجدوا
+
+317
+00:24:13,410 --> 00:24:18,630
+أن الأنابيب هذه اللي بتوصل من المبيض حتى الرحم
+
+318
+00:24:18,630 --> 00:24:23,670
+مبطنة بالداخل بالسيليا وهي كمان فيها ميوكاس هذه
+
+319
+00:24:23,670 --> 00:24:27,150
+السيليا والميوكاس بتساعد البويضة على الحركة
+
+320
+00:24:27,150 --> 00:24:31,790
+الميوكاس بتعمل كمادة تشحين تساعد انزلاق البويضة و
+
+321
+00:24:31,790 --> 00:24:35,610
+السيليا أيضا تدفع البويضة وتسرق من عملية انزلاقة
+
+322
+00:24:35,610 --> 00:24:40,660
+وصولا للرحمولكن عملية وجود السيليا ليس عملية
+
+323
+00:24:40,660 --> 00:24:45,100
+وحركتها ليس عملية إجبارية لأن بعض الدراسات العلمية
+
+324
+00:24:45,100 --> 00:24:49,420
+وجدت أن بعض السيدات تفتقر إلى السيليا تحت مصطلح
+
+325
+00:24:49,420 --> 00:24:54,340
+Immatile Celiac Syndrome ولكنها ما زالت قادرة على
+
+326
+00:24:54,340 --> 00:24:58,940
+الإنجاب وصنفت as fertile women or fertile female
+
+327
+00:25:00,930 --> 00:25:04,830
+عملية نقل البويضة من خلال الأنابيب التي تسمى
+
+328
+00:25:04,830 --> 00:25:09,930
+tubular transport تستغرق حوالي 3 إلى 4 أيام، يعني
+
+329
+00:25:09,930 --> 00:25:13,170
+بويضة أول ما تدخل في الـopiate tube بفعل
+
+330
+00:25:13,170 --> 00:25:17,010
+الـligament، بفعل عملية الـcatching لها، تأخذ من 3
+
+331
+00:25:17,010 --> 00:25:21,730
+إلى 4 أيام سواء كانت هذه البويضة مخصبة أو غير مخصة
+
+332
+00:25:23,170 --> 00:25:27,230
+لأنه لو كانت مخصبة هتنزل للرحل اللي يترس على شكل
+
+333
+00:25:27,230 --> 00:25:31,450
+embryo و لو كانت غير مخصبة هتنزل على شكل oocyte و
+
+334
+00:25:31,450 --> 00:25:37,210
+تطلع معه ل bleeding each fallopian tube طولها ..
+
+335
+00:25:37,210 --> 00:25:42,130
+كل fallopian tube طوله ما يقارب من 10 إلى 13 cm طب
+
+336
+00:25:42,130 --> 00:25:45,390
+ال egg transport لها نفس ال phase أم لها phase
+
+337
+00:25:45,390 --> 00:25:49,250
+مختلفة؟ وجد العلماء أن ال egg transportation as a
+
+338
+00:25:49,250 --> 00:25:53,100
+process تمر ب two phaseالـ phase الأول وهو ال
+
+339
+00:25:53,100 --> 00:25:57,840
+slowly transport و بتناول و بيستغرق حوالي 72 ساعة
+
+340
+00:25:57,840 --> 00:26:03,160
+يليه ال more rapid phase و بتستغرق حوالي 8 ساعات
+
+341
+00:26:03,160 --> 00:26:06,800
+during which the egg or the embryo pays through
+
+342
+00:26:06,800 --> 00:26:11,940
+the isthmus and into uterus يعني بمعنى أخر أن ال
+
+343
+00:26:11,940 --> 00:26:17,700
+slowly transportation phase بيستغرق 72 ساعة وهو
+
+344
+00:26:17,700 --> 00:26:20,740
+بيقطع هذه ال 72 ساعة بس بيقطع
+
+345
+00:26:23,770 --> 00:26:28,250
+عشرة لتلتاشر centimeter أما ال rapid phase اللي
+
+346
+00:26:28,250 --> 00:26:32,510
+بيستغرب تمان ساعات فقط تقطع المنحنة ما بين ال
+
+347
+00:26:32,510 --> 00:26:36,310
+fallopian tube و اليوتراس اللي بتسميه ال isthmus
+
+348
+00:26:36,310 --> 00:26:39,750
+أو المضيق، هنشوفه كمان بشوية في الصورة if
+
+349
+00:26:39,750 --> 00:26:42,450
+fertilized has not occurred, the egg will be
+
+350
+00:26:42,450 --> 00:26:46,650
+degenerated and is phagocytes يعني والله إذا كانت
+
+351
+00:26:46,650 --> 00:26:49,430
+الويضة ماصللش fertilization ممكن يصيلها
+
+352
+00:26:49,430 --> 00:26:51,070
+degeneration في ال fallopian tube، وبعدين
+
+353
+00:26:51,070 --> 00:26:57,590
+phagocytosisالأخضر وظلت يصير عملية تدحر جوصنا
+
+354
+00:26:57,590 --> 00:27:02,550
+لليوترست هتنزل مع ال bleeding و لكن .. و لكن .. و
+
+355
+00:27:02,550 --> 00:27:09,030
+لكن الأكتر دقة و الأصح أن عمر الويضة 24 ساعة
+
+356
+00:27:09,030 --> 00:27:13,550
+فبالتالي طالما هي 24 ساعة هتمكس في الفلوبيا التي
+
+357
+00:27:13,550 --> 00:27:18,190
+هو تتحرك بعد 24 ساعة يعني بعد يوم ما صدرش
+
+358
+00:27:18,190 --> 00:27:24,590
+fertilization هتستغرق لنقلها للإزمس 72 ساعةأخدت من
+
+359
+00:27:24,590 --> 00:27:30,670
+الـ 72 ساعة لـ 24 ساعة ليه؟ as half-life عشان
+
+360
+00:27:30,670 --> 00:27:38,530
+تتلقح أو ما تتلقح ما تلقحتش لسه دايلها كمان 24 و
+
+361
+00:27:38,530 --> 00:27:43,370
+24 فبالتالي بيصير لها عملية degradation يعني ما
+
+362
+00:27:43,370 --> 00:27:47,150
+اتصل لـ Rabbit phase يعني بيصير عملية degradation
+
+363
+00:27:47,150 --> 00:27:50,810
+برجع بأكد مرة تانيةإن البويضة تستقر في ال
+
+364
+00:27:50,810 --> 00:27:54,930
+Fallopian tube 24 ساعة ال half-life حقوق تبعتها 24
+
+365
+00:27:54,930 --> 00:28:00,330
+ساعة بعد 24 ساعة ماصارش إلها عملية تلقيح لهذه
+
+366
+00:28:00,330 --> 00:28:03,890
+البويضة البويضة مباشرة بيصيلها degradation و بعدين
+
+367
+00:28:03,890 --> 00:28:09,250
+باجو سيتوسيز طب ليش مابتكمل؟ لإن عملية إكمالها
+
+368
+00:28:09,250 --> 00:28:13,290
+للوصول إلى اليوترست بتحتاج إلى 72 ساعة من ال 72
+
+369
+00:28:13,290 --> 00:28:16,210
+ساعة أصطغر في ال 24 ساعة عشان بس يصيلها
+
+370
+00:28:16,210 --> 00:28:19,720
+fertilization ولا لأسرلة فيرتاليزيشن بتكمل أو
+
+371
+00:28:19,720 --> 00:28:24,280
+بتقطع، ما سرلهاش بسرلة self-degradation أو بعد كده
+
+372
+00:28:24,280 --> 00:28:28,540
+Vagocytosis هذا الشكل اللي احنا بنحكي عنه، هذا الـ
+
+373
+00:28:28,540 --> 00:28:32,620
+ligament هنا اللي طبعا المبيض وهذه الجرفيا
+
+374
+00:28:32,620 --> 00:28:38,600
+الفوليكل وصلت لدامي أكتر من 18 مليمتر الفوليكل،
+
+375
+00:28:38,600 --> 00:28:41,460
+يعني دا ليه ان أنا mature؟ بيبدأ يصير عملية ال
+
+376
+00:28:41,460 --> 00:28:44,640
+ovulation، خروج البوادة ال ligament هذه اللي
+
+377
+00:28:44,640 --> 00:28:47,200
+موجودة في نهاية الفلوبي نفسيوك بتكون flexible
+
+378
+00:28:47,850 --> 00:28:54,850
+Ciliated و قادرة على ال contraction فبتعمل
+
+379
+00:28:54,850 --> 00:28:59,390
+Catching أو Capturing للـ Oocyte أو للـ Ova لازم
+
+380
+00:28:59,390 --> 00:29:02,750
+يصلها fertilization في هذه المنطقة في رتولة الأول
+
+381
+00:29:02,750 --> 00:29:06,310
+أو ربع الأول من Fallopian Tube طبعا سيلها ماشية
+
+382
+00:29:06,310 --> 00:29:11,450
+تقطع هذه العملية كلها تحتاج 72 ساعة عشان تدخل
+
+383
+00:29:11,450 --> 00:29:14,570
+المضيق هذا و هي المنطقة التي تفصل Fallopian Tube
+
+384
+00:29:14,570 --> 00:29:21,600
+على اليوترات تقدرها 8 ساعاتفي أول 24 ساعة هي
+
+385
+00:29:21,600 --> 00:29:24,520
+فرصتها لل fertilization بعد كده يصيبها degradation
+
+386
+00:29:24,520 --> 00:29:29,920
+و elimination ما بتكمل للآخر ما بتكمل للآخر خلينا
+
+387
+00:29:29,920 --> 00:29:35,180
+نشوف الفيديو اللي بحكي في هذا الموضوع كيف تنتقل
+
+388
+00:29:35,180 --> 00:29:39,760
+الجو أيضا ovulation is the release of an egg from
+
+389
+00:29:39,760 --> 00:29:42,640
+one of the ovaries it often happens about midway
+
+390
+00:29:42,640 --> 00:29:45,260
+through the menstrual cycle although the exact
+
+391
+00:29:45,260 --> 00:29:48,980
+timing may varyIn preparation for ovulation, the
+
+392
+00:29:48,980 --> 00:29:51,520
+lining of the uterus, or endometrium, thickens.
+
+393
+00:29:52,160 --> 00:29:55,080
+The pituitary gland in the brain stimulates one of
+
+394
+00:29:55,080 --> 00:29:58,260
+the ovaries to release an egg. The wall of the
+
+395
+00:29:58,260 --> 00:30:00,820
+ovarian follicle ruptures at the surface of the
+
+396
+00:30:00,820 --> 00:30:04,740
+ovary. The egg is released. Finger-like structures
+
+397
+00:30:04,740 --> 00:30:07,500
+called fembrae sweep the egg into the neighboring
+
+398
+00:30:07,500 --> 00:30:12,160
+fallopian tube.الليمين سماه هنا finger-like
+
+399
+00:30:12,160 --> 00:30:15,490
+structureالطيب يسير من خلال الـ Fallopian Tube
+
+400
+00:30:15,490 --> 00:30:17,670
+تحريره بشكل أكبر من التعبيرات في أعضاء الـ
+
+401
+00:30:17,670 --> 00:30:22,230
+Fallopian Tube هنا في الـ Fallopian Tube الطيب
+
+402
+00:30:22,230 --> 00:30:27,050
+يمكن أن يكون مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+403
+00:30:27,050 --> 00:30:27,350
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+404
+00:30:27,350 --> 00:30:27,690
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+405
+00:30:27,690 --> 00:30:27,690
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+406
+00:30:27,690 --> 00:30:36,530
+مجرد مجرد مجرد مجرد
+
+407
+00:30:36,530 --> 00:30:41,630
+مج
+
+408
+00:30:42,010 --> 00:30:45,250
+طبعا بيحكيلي إذا الـ oocyte صلى fertilization في
+
+409
+00:30:45,250 --> 00:30:49,090
+الفلوبيان الـ tube، هيصيرلها عملية division بشكل
+
+410
+00:30:49,090 --> 00:30:52,750
+مستمر جدا، هتتكون لـ cluster أو complex من
+
+411
+00:30:52,750 --> 00:30:57,790
+الخلايا، تبدأ بالزيجوت، بعد كده هتبدأ تستمر رحلتها
+
+412
+00:30:57,790 --> 00:31:02,010
+وصولا إلى اليوتراب When the zygote reaches the
+
+413
+00:31:02,010 --> 00:31:04,790
+uterus, it implants in the lining of the uterus,
+
+414
+00:31:04,970 --> 00:31:06,250
+and pregnancy begins
+
+415
+00:31:13,720 --> 00:31:18,800
+معلومة مهمة جدا البويضة إن خُصبة هتستمر في عملية
+
+416
+00:31:18,800 --> 00:31:22,840
+الانقسام المتتالي لوصول إلى عدد كبير جدا من
+
+417
+00:31:22,840 --> 00:31:27,460
+الخلايا اللي هتعبر ال isthmus وصولا إلى الرحم و
+
+418
+00:31:27,460 --> 00:31:31,160
+تنغمس فيه بداية لتكوين الجنين ولكن ذكروا في
+
+419
+00:31:31,160 --> 00:31:35,340
+الفيديو إذا البويضة لم تخصب سوف يصير يحدث عملية
+
+420
+00:31:35,340 --> 00:31:41,530
+degradationو self degradation و vagocytosis أو
+
+421
+00:31:41,530 --> 00:31:45,710
+self absorption قبل ما تصل اليوترا بمعنى آخر قبل
+
+422
+00:31:45,710 --> 00:31:58,750
+ما تدخل الإزماس في أول 72 ساعة طبعا
+
+423
+00:32:06,570 --> 00:32:09,510
+بعد .. بعد هذه العملية ما تخلص و ما تصارى شهرية
+
+424
+00:32:09,510 --> 00:32:13,550
+fertilization بسفوعين تكمل الدورة تبدأ ودورة شهرية
+
+425
+00:32:13,550 --> 00:32:18,270
+جد الجديدة نسميها menstruation أو الدورة الشهرية
+
+426
+00:32:18,270 --> 00:32:23,870
+هذا بالنسبة لعملية انتقال البويضة من لحظة تخليقها
+
+427
+00:32:23,870 --> 00:32:29,580
+و نضوجها مرورا بوصولها إلى الرحم أو بنقاط الرحمنجي
+
+428
+00:32:29,580 --> 00:32:33,680
+لشقة تانية المتعلقة بالـ Male Gametes وهو عبارة عن
+
+429
+00:32:33,680 --> 00:32:37,620
+الـ spermatozoa تحت أنواع sperm transportation أو
+
+430
+00:32:37,620 --> 00:32:41,000
+الـ transport ال sperm transport occur in both
+
+431
+00:32:41,000 --> 00:32:43,820
+male reproductive tract and female reproductive
+
+432
+00:32:43,820 --> 00:32:47,020
+tract يعني ما بقدر أقول إن عملية نقل الجامعتان
+
+433
+00:32:47,020 --> 00:32:50,220
+الذكرية فقط تحدث في ال reproductive system للمالي
+
+434
+00:32:50,220 --> 00:32:53,440
+لأ في كمان تحدث في reproductive system لل female
+
+435
+00:32:53,440 --> 00:32:57,260
+وتكون الأصعب لإن ال sperm في أندهي في ال
+
+436
+00:32:57,260 --> 00:33:01,330
+reproductive system لل femaleهي عبارة عن رحلة
+
+437
+00:33:01,330 --> 00:33:06,350
+محفوفة بالمخاطر وصولا إلى مكان تلقيح البويضة في
+
+438
+00:33:06,350 --> 00:33:09,450
+الـ Fallopian tube هنعرف أيش المخاطر والصعوبات
+
+439
+00:33:09,450 --> 00:33:12,770
+اللي بواجهتها الـ sperm انتقالا من منطقة الفيجاينة
+
+440
+00:33:12,770 --> 00:33:16,410
+حتى وصولا إلى الـ Fallopian tube in the male
+
+441
+00:33:16,410 --> 00:33:19,350
+reproductive tract, transport of spermatozoa is
+
+442
+00:33:19,350 --> 00:33:22,870
+closely connected with their structural and
+
+443
+00:33:22,870 --> 00:33:28,000
+functional maturation يعني ينتقل ال sperm في الـمن
+
+444
+00:33:28,000 --> 00:33:31,180
+مكان التصنيع لمكان التخزين ثم Ejaculation في
+
+445
+00:33:31,180 --> 00:33:35,260
+الخارج بينما .. فبالتالي البيئة واحدة .. البيئة
+
+446
+00:33:35,260 --> 00:33:38,540
+واحدة خاصة بال reproductive system and ال male
+
+447
+00:33:38,540 --> 00:33:43,440
+البيئة واحدة خاصة بالتصنيع والنضوج والتخزين مافيش
+
+448
+00:33:43,440 --> 00:33:47,980
+أي مخاطر عليه إلا إذا كان بيكون self-antibody ضده
+
+449
+00:33:47,980 --> 00:33:52,220
+In female reproductive tract it is important for
+
+450
+00:33:52,220 --> 00:33:55,920
+spermatozoa to pass or transport to the upper
+
+451
+00:33:55,920 --> 00:34:01,390
+uterine tubeWhere they can meet with oocyte to
+
+452
+00:34:01,390 --> 00:34:04,770
+fertilize مهم جدا بالنسبة للـ reproductive tract
+
+453
+00:34:04,770 --> 00:34:09,530
+إن الـ sperm يقطع مسافة خطرة ومحفوفة بالمخاطر من
+
+454
+00:34:09,530 --> 00:34:14,350
+بداية الـ cervic حتى وصولا إلى الأنابيب فلوب يلتقي
+
+455
+00:34:14,350 --> 00:34:16,930
+هناك مع البوايدة لكي يحدث عملية ال fertilization
+
+456
+00:34:16,930 --> 00:34:20,670
+بعد ما يصير عملية الـ spermatogenesis في
+
+457
+00:34:20,670 --> 00:34:25,870
+سيمينيرفستبيول يُنقل لحيوان منويأو النطفة إلى الـ
+
+458
+00:34:25,870 --> 00:34:32,070
+Epidermis من أجل التخزين والنضوج أثناء عملية نقله
+
+459
+00:34:32,070 --> 00:34:40,130
+يكون هذا الـ sperm mature but are non-motile يعني
+
+460
+00:34:40,130 --> 00:34:46,250
+خلال عملية تصنيعه إلى حد ما وعملية نقله يكون
+
+461
+00:34:46,250 --> 00:34:50,330
+mature already ولكن non-functional، non-motile
+
+462
+00:34:50,330 --> 00:34:56,180
+unable for fertilizationمهم جدا أن هذا الـ sperm
+
+463
+00:34:56,180 --> 00:35:02,320
+صار mature و ينقل إلى الـ Epidermis لكي يخزن و
+
+464
+00:35:02,320 --> 00:35:07,000
+يحدث له عملية ال functionality بمعنى أخر اكتساب
+
+465
+00:35:07,000 --> 00:35:14,680
+القدرة على الحركة من خلال طباول الفلاجلة و اكتساب
+
+466
+00:35:14,680 --> 00:35:18,860
+قدرته على اخصاب البعد ال spermatozoa تنتقل من ال
+
+467
+00:35:18,860 --> 00:35:22,980
+seminal vestibuleإلى الـ Epidermis بطريقة معينة
+
+468
+00:35:22,980 --> 00:35:25,580
+تسمى الـ passive transportation ال passive
+
+469
+00:35:25,580 --> 00:35:28,680
+transportation يعني عبارة عن عملية لا تحتاج إلى
+
+470
+00:35:28,680 --> 00:35:34,700
+داقة فبالتالي الشول بيخليها تنقل ببساطة to the
+
+471
+00:35:34,700 --> 00:35:40,120
+head of the epidermis يعني في بعض ال fluid يفرز
+
+472
+00:35:40,120 --> 00:35:44,560
+يساعد في نقل ال sperm اللي mature بعد ما صُنّى في
+
+473
+00:35:44,560 --> 00:35:48,200
+ال semi-nervous ينقل من ال semi-nervous to الhead
+
+474
+00:35:48,200 --> 00:35:51,960
+of the epidermisالـ Epidermis منطقة مهمة جدًا
+
+475
+00:35:51,960 --> 00:35:55,480
+للمتوراش والـ functionality الخاصة من الـ sperm
+
+476
+00:35:55,480 --> 00:36:00,120
+طبعًا الـ sperm حوالي بستغرب 12 يوم in high
+
+477
+00:36:00,120 --> 00:36:05,240
+equivalent duct of the epidermis which measured 60
+
+478
+00:36:05,240 --> 00:36:09,520
+meter in the human during which they undergo
+
+479
+00:36:09,520 --> 00:36:13,780
+biochemical maturation يعني الـ epidermis هذا طوله
+
+480
+00:36:13,780 --> 00:36:18,360
+حوالي 6 مترالحيوان الملو يستقر فيه ويستغرق فيه 6
+
+481
+00:36:18,360 --> 00:36:23,500
+أيام 12 يوم 6 متر يستغرق الحيوان الملو فيه 12 يوم
+
+482
+00:36:23,500 --> 00:36:29,760
+خلال 12 يوم يكتسب النقاط القدرة العالية على التطور
+
+483
+00:36:29,760 --> 00:36:35,480
+والنضوج بالشكل الكامل تحت مصطلح biochemical
+
+484
+00:36:35,480 --> 00:36:39,080
+maturation شو يحصل في هذه العملية
+
+485
+00:36:45,640 --> 00:36:48,040
+أول شغلة بيصير فيها من الـ maturation أو الـ
+
+486
+00:36:48,040 --> 00:36:50,840
+exchange أو الـ variation إن هناك بعض التغيرات
+
+487
+00:36:50,840 --> 00:36:54,620
+التي تحدث على الـ glycoprotein الموجود في الـ cell
+
+488
+00:36:54,620 --> 00:36:57,240
+membrane أو الـ plasma membrane الخاصة بالـ head
+
+489
+00:36:57,240 --> 00:37:02,000
+sphere by the time spermatozoa have arrived at the
+
+490
+00:37:02,000 --> 00:37:05,480
+tail of the epidermis they are capable of
+
+491
+00:37:05,480 --> 00:37:10,120
+fertilizing it بعد هذه الأتناشر يوم ما تبدأ تمضي
+
+492
+00:37:10,430 --> 00:37:14,010
+بشكل أو باخر تبدأ الحيوانات المنوية في الوصول إلى
+
+493
+00:37:14,010 --> 00:37:17,810
+نهاية الـ Epidermis دليل على أنها اكتسبت القدرة
+
+494
+00:37:17,810 --> 00:37:24,290
+على الحركة والقدرة على عملية التخصيب لذا سوف تنطلق
+
+495
+00:37:24,290 --> 00:37:27,670
+لكي تؤدي الوظيفة المطلوبة منها من خلال عملية
+
+496
+00:37:27,670 --> 00:37:31,030
+بتسميها ال ejaculation ال ejaculation هي عبارة عن
+
+497
+00:37:31,030 --> 00:37:38,600
+عملية خروج المطف من الإنسان إلىإلى الـ cervix أو
+
+498
+00:37:38,600 --> 00:37:43,920
+الفجرية الـ sperm will be rapidly passed through
+
+499
+00:37:43,920 --> 00:37:51,560
+the venous difference and are mixed with the fluid
+
+500
+00:37:51,560 --> 00:37:55,360
+secretion from the seminal vesicle and prostatic
+
+501
+00:37:55,360 --> 00:37:59,320
+gland لحظة ال ejaculation يتم نقل الحيوانات
+
+502
+00:37:59,320 --> 00:38:02,760
+المنوية أو النطف الذكيرية بفعل ال fast difference
+
+503
+00:38:02,760 --> 00:38:09,980
+للخارج ولكنما تنقل للخارج لوحدها، لأ، تنقل خليط مع
+
+504
+00:38:09,980 --> 00:38:15,380
+ال fluid الذي يفرز من ال seminal vesicles بالإضافة
+
+505
+00:38:15,380 --> 00:38:18,680
+للبرستاتيكي كلها يعني ال seminal fluid اللي هناخده
+
+506
+00:38:18,680 --> 00:38:22,660
+مستقبلا في محاضرة خاصة فيه، هو عبارة عن خليط من ال
+
+507
+00:38:22,660 --> 00:38:27,290
+spermatozoa، الموقف الذكري و ال fluidيخرج من منطقة
+
+508
+00:38:27,290 --> 00:38:31,530
+تانية منطقة لها علاقة بالـ seminal vesicles النبيب
+
+509
+00:38:31,530 --> 00:38:35,710
+المنوية ومنطقة تسمى ال prostatic gland غُدّة
+
+510
+00:38:35,710 --> 00:38:39,270
+البرستاتا طبعا ال prostatic fluid اللي يخرج من
+
+511
+00:38:39,270 --> 00:38:43,690
+البرستاتا غني ببعض المواد زي ال citric acid زي
+
+512
+00:38:43,690 --> 00:38:48,070
+الacidic phosphatase زي الزنك وزي المغنيزيوم بينما
+
+513
+00:38:48,070 --> 00:38:50,990
+الفلويد اللي بيخرج من ال seminal vesicle غني
+
+514
+00:38:50,990 --> 00:38:56,220
+بالفراكتوزوالفراكتوز يعتبر من أهم مصادر الطاقة
+
+515
+00:38:56,220 --> 00:39:00,940
+الخاصة بالحيوان المنوي قطف إلى الفراكتوز بيكون خاص
+
+516
+00:39:00,940 --> 00:39:04,000
+في مادة أخرى ال prostaglandin يعني similar to
+
+517
+00:39:04,000 --> 00:39:07,920
+physical بيخرج fluid لفلويد غني بالفراكتوز و
+
+518
+00:39:07,920 --> 00:39:11,350
+للبروستاجلاندينالـ prostatic gland أو الـ
+
+519
+00:39:11,350 --> 00:39:14,890
+prostatic gland تخرج fluid غني بالزنك و ال citric
+
+520
+00:39:14,890 --> 00:39:19,650
+acid و الفوسفاتيز و الميجنيزيو طب سؤالي لماذا
+
+521
+00:39:19,650 --> 00:39:22,710
+يستخدم ال sperm ال fractose و لا يستخدم الجليكوز
+
+522
+00:39:22,710 --> 00:39:27,410
+لأن احتراق الجليكوز أسرع من احتراق الجليكوز
+
+523
+00:39:27,410 --> 00:39:33,930
+وبالتالي طالما ال sperm يتحرك بسرعة هائلة فبيحتاج
+
+524
+00:39:33,930 --> 00:39:38,630
+إلى كمية كبيرة من الطاقة تحرق بسرعةأضف إلى ذلك إنه
+
+525
+00:39:38,630 --> 00:39:44,230
+إن الـ sperm الـ cell يلتقل إلى بعض الإنذيمات
+
+526
+00:39:44,230 --> 00:39:47,750
+المسؤولة عن ال consuming للجليكوز واستهلاك
+
+527
+00:39:47,750 --> 00:39:51,470
+الجليكوز ومن أشهرها ال Exokinase for example فما
+
+528
+00:39:51,470 --> 00:39:56,170
+بيقدر يستخدم الجليكوز فبيستخدم ال fractose أسرع في
+
+529
+00:39:56,170 --> 00:40:01,950
+الاحتراف وتماشى مع الإنذيمات التي يمتلكها صورة
+
+530
+00:40:01,950 --> 00:40:07,310
+بتوضح الكلام اللي أنا حكيته من خلالالـ Testes وهي
+
+531
+00:40:07,310 --> 00:40:11,750
+المصنع الخاص بتصنيع الحيوانات المنوية أو النطف
+
+532
+00:40:11,750 --> 00:40:15,230
+التكارية في منطقة سميها Seminerval Stipule يتم
+
+533
+00:40:15,230 --> 00:40:17,970
+نقلها إلى الـ Epidermis عن طريق الـ Passive
+
+534
+00:40:17,970 --> 00:40:22,210
+Transportation الـ Epidermis في الـ Head يبقى 12
+
+535
+00:40:22,210 --> 00:40:24,590
+يوم من أجل عملية الـ Maturation و الـ
+
+536
+00:40:24,590 --> 00:40:29,230
+Functionality بعدين بيصلتل Epidermis ينتقل من خلال
+
+537
+00:40:29,230 --> 00:40:33,550
+ما يُعرف باسم الـ Vase Difference إلى قناة الـ
+
+538
+00:40:33,550 --> 00:40:37,870
+Ejaculation، قناة الخروجأو قلة القلب في الـ Vase
+
+539
+00:40:37,870 --> 00:40:41,970
+Difference يتم خلطه بـ Fluid تأتي جزء من الـ
+
+540
+00:40:41,970 --> 00:40:45,890
+Prostatic Fluid و Fluid آخر يأتي من الـ Seminal
+
+541
+00:40:45,890 --> 00:40:50,390
+Vesicle طبعا هذه الـ Fluid مهمة جدا في حماية الـ
+
+542
+00:40:50,390 --> 00:40:54,290
+Spermatozoa و في تغذية الـ Spermatozoa في حماية و
+
+543
+00:40:54,290 --> 00:40:58,050
+تغذية الـ Spermatozoa يعني ديش الـ sperm بيقعد في
+
+544
+00:40:58,050 --> 00:41:03,750
+limited mass 12 يوم أو أسبوعين على حد أقصىالـ
+
+545
+00:41:03,750 --> 00:41:06,550
+Sperm Maturation in Epidermis شو بيصير في الـ
+
+546
+00:41:06,550 --> 00:41:09,930
+sperm من maturation أو variation في الـ Epidermis
+
+547
+00:41:09,930 --> 00:41:13,810
+أول حاجة بيكتسب القدرة على ال progressive motility
+
+548
+00:41:13,810 --> 00:41:17,090
+و لما أقول progressive motility يعني الحركة التي
+
+549
+00:41:17,090 --> 00:41:20,970
+تحدث في اتجاه واحد وبشكل مستقيم progressive
+
+550
+00:41:20,970 --> 00:41:25,870
+motility بيزيد قدرته على تخصيب القواعدة بيعمل
+
+551
+00:41:25,870 --> 00:41:29,610
+change في مادة البروتين الموجودة داخل ال sperm
+
+552
+00:41:29,610 --> 00:41:34,680
+فبيخلي ال sperm تتخرجMaturation of Acrosome، والـ
+
+553
+00:41:34,680 --> 00:41:37,640
+Acrosome باكل بيحتوى على كمية كبيرة جدا من الـ
+
+554
+00:41:37,640 --> 00:41:40,880
+lytic enzyme أو الإنزماق الهاضمة التي تساعد في
+
+555
+00:41:40,880 --> 00:41:43,980
+عملية ال penetration بيعمل تغيير في الـ plasma
+
+556
+00:41:43,980 --> 00:41:48,180
+membrane بيخلّي ال sperm أكثر ملائمة لعملية ال
+
+557
+00:41:48,180 --> 00:41:54,180
+fertilizationباكتسب الـ sperm قدرة على امتلاك
+
+558
+00:41:54,180 --> 00:41:57,960
+ريسيبتور خاصة بالـ zoonabulisida يعني بمعنى آخر
+
+559
+00:41:57,960 --> 00:42:00,800
+بيصير more specific أنه يرتبط بالـ zoonabulisida
+
+560
+00:42:00,800 --> 00:42:06,300
+الموجودة as outer layer خاصة بالـ oocyte بدونها،
+
+561
+00:42:06,300 --> 00:42:09,640
+مش هيقدر يتعرف على هذا الريسيبتور increased
+
+562
+00:42:09,640 --> 00:42:13,900
+disulfide bond between the nucleoprotein وهذا الـ
+
+563
+00:42:13,900 --> 00:42:17,120
+disulfide bond بتخليه more stable بيخلي البروتين
+
+564
+00:42:17,120 --> 00:42:21,840
+أو بيخلي المادة الوراقيةmore stable تقوم المواد
+
+565
+00:42:21,840 --> 00:42:25,300
+وتقوم العقبات اللي هتواجهها في عملية انتقالها
+
+566
+00:42:25,300 --> 00:42:27,140
+للفلوجيا من الـ tube عندما تصل إلى الـ
+
+567
+00:42:27,140 --> 00:42:31,020
+reproductive system الخاص بالفيميل فال stability
+
+568
+00:42:31,020 --> 00:42:36,400
+بتصير أعلى accumulation of manosalate residue on
+
+569
+00:42:36,400 --> 00:42:41,300
+the acrosome plasma membrane طبعا هذا أيضا بيخليها
+
+570
+00:42:41,300 --> 00:42:46,600
+more stable في عملية الانتقال في عملية الانتقال
+
+571
+00:42:48,000 --> 00:42:50,820
+طبعا message of sperm through the female
+
+572
+00:42:50,820 --> 00:42:55,660
+reproductive tract is regularity to maximum of its
+
+573
+00:42:55,660 --> 00:42:58,360
+chance of fertilization and ensure that sperm with
+
+574
+00:42:58,360 --> 00:43:02,640
+normal morphology and motility will be once to
+
+575
+00:43:02,640 --> 00:43:06,060
+success يعني نقل ال sperm خلال ال reproductive
+
+576
+00:43:06,060 --> 00:43:10,960
+system لازم نحافظ على ال sperm بكامل هيئته، بكامل
+
+577
+00:43:10,960 --> 00:43:15,630
+نشاطه، بكامل حيويته، بكامل وظرفهالحفاظ على الـ
+
+578
+00:43:15,630 --> 00:43:20,650
+sperm بكامل هذه المؤشرات يساعد على زيادة فرصة ال
+
+579
+00:43:20,650 --> 00:43:25,770
+fertilization مما يساعد على حدوث الحمل والحصول على
+
+580
+00:43:25,770 --> 00:43:30,310
+بيبي أو إمبريو ال sperm are subject to physical
+
+581
+00:43:30,310 --> 00:43:34,350
+stress during ejaculation and contraction of the
+
+582
+00:43:34,350 --> 00:43:38,720
+femoral tract and they may be oxidativeيعني بمعنى
+
+583
+00:43:38,720 --> 00:43:41,480
+أخر خلال عملية الـ ejaculation في ال reproductive
+
+584
+00:43:41,480 --> 00:43:45,980
+system الخاص بالفيميل بسبب بواجه كمية كبيرة جدا من
+
+585
+00:43:45,980 --> 00:43:50,120
+المعوقات والمخاطر أولهم ال stress ال physical
+
+586
+00:43:50,120 --> 00:43:53,360
+stress الناتج عن اختلاف ال environment ما بين ال
+
+587
+00:43:53,360 --> 00:43:56,100
+reproductive system الخاص بالفيميل و reproductive
+
+588
+00:43:56,100 --> 00:43:59,660
+system الخاص بالفيميل أو ما يُعرف اسم ال
+
+589
+00:43:59,660 --> 00:44:02,640
+reproductive tract male reproductive tract أو
+
+590
+00:44:02,640 --> 00:44:05,650
+female reproductive tractأضف إلى ذلك الـ
+
+591
+00:44:05,650 --> 00:44:08,990
+contraction الخاص بالـ female tract الـ female
+
+592
+00:44:08,990 --> 00:44:11,730
+tract الخاص بالـ reproductive tract عند الفميل
+
+593
+00:44:11,730 --> 00:44:14,770
+فيها contraction مختلفة عن ال contraction الموجودة
+
+594
+00:44:14,770 --> 00:44:18,730
+عند المال فبالتالي هذا يكبر أحد المخاطر والصعوبات
+
+595
+00:44:18,730 --> 00:44:22,430
+اللي بوجهها ال sperm أضف إلى ذلك ال oxidative
+
+596
+00:44:22,430 --> 00:44:27,530
+damage بفعل اختلاف ال pH واختلاف المواد الموجودة
+
+597
+00:44:27,530 --> 00:44:33,360
+عند الفميل عن المال because sperm are allogenicto
+
+598
+00:44:33,360 --> 00:44:38,820
+female they may be prepared and activated the
+
+599
+00:44:38,820 --> 00:44:46,740
+immune system باختلاف الطبيعة الـ sperm عن الهيئة
+
+600
+00:44:46,740 --> 00:44:49,900
+أو خلّيني أقول عن البيئة الخاصة بال reproductive
+
+601
+00:44:49,900 --> 00:44:55,440
+system عند ال female الجهاز التنفسي اللي عند ال
+
+602
+00:44:55,440 --> 00:44:59,480
+female بيتعرف على ال sperm كأنه abnormal or
+
+603
+00:44:59,480 --> 00:45:03,710
+foreign substanceفبحث الجهاز المناعة مما يؤدي إلى
+
+604
+00:45:03,710 --> 00:45:08,510
+تدميره علشان كده بلاقي دايما ال normal sperm count
+
+605
+00:45:08,510 --> 00:45:13,390
+تكون بالملايين علشان لو صار فيه reduction في ال
+
+606
+00:45:13,390 --> 00:45:17,390
+count الخاص بال sperm أثناء نقله من ال .. في خلال
+
+607
+00:45:17,390 --> 00:45:20,150
+ال reproductive .. female reproductive tract
+
+608
+00:45:20,150 --> 00:45:25,110
+transportation process يظل في عندي عدد يكفي لعملية
+
+609
+00:45:25,110 --> 00:45:29,110
+ال fertilization during intercourses or coitus
+
+610
+00:45:32,600 --> 00:45:35,780
+the upper vagina to grow close to the cervix يعني
+
+611
+00:45:35,780 --> 00:45:39,980
+خلال عملية الإبتصال كل sperm أو كل السيمن بيقع في
+
+612
+00:45:39,980 --> 00:45:43,560
+منطقة معينة تعرف باسم ال upper vagina وهي عبارة عن
+
+613
+00:45:43,560 --> 00:45:47,220
+منطقة قريبة جدا من ال cervix وهو عنق الرحب اللذي
+
+614
+00:45:47,220 --> 00:45:50,640
+يعتبر بوابة ال reproductive system الخاصة بال
+
+615
+00:45:50,640 --> 00:45:55,980
+female the normal environment of vaginais unstable
+
+616
+00:45:55,980 --> 00:46:03,620
+for sperm لأنها تقريبا أقل من خمسة pH أقل من خمسة
+
+617
+00:46:03,620 --> 00:46:07,680
+فبالتالي الـ pH الخاصة بالفيلاينة و الخاصة
+
+618
+00:46:07,680 --> 00:46:13,500
+بالفيميل تكون أقل من خمسة pH فالي انستابل للسبرم
+
+619
+00:46:13,500 --> 00:46:17,300
+فلا تساعد على بقاء السبرم بالشكل الحي أو بالشكل
+
+620
+00:46:17,300 --> 00:46:22,080
+المطلوب مما يؤدي إلى ثلاث كمية كبيرة جدا و عدد
+
+621
+00:46:22,080 --> 00:46:28,730
+كبير جدا من السبرمالـ lower pH of vagina is a
+
+622
+00:46:28,730 --> 00:46:31,970
+protective mechanism for women against many
+
+623
+00:46:31,970 --> 00:46:35,350
+sexually transmitted pathogens يعني بمعنى أخر هذه
+
+624
+00:46:35,350 --> 00:46:38,630
+الـ pH الأقل من خالصها ما بيكون بشكل عشوائي وشكل
+
+625
+00:46:38,630 --> 00:46:42,150
+غير مدروس لأ، مهم جدا عشان يحمي ال reproductive
+
+626
+00:46:42,150 --> 00:46:45,790
+system الخاص بالفيميل من ال sexually transmitted
+
+627
+00:46:45,790 --> 00:46:49,730
+disease sexually transmitted disease، so this pH
+
+628
+00:46:49,730 --> 00:46:52,630
+working like fires حوارز
+
+629
+00:46:55,050 --> 00:47:01,870
+مجارات مباشرة شهدت أنه في 10 ثانية من إدارة الحركة
+
+630
+00:47:01,870 --> 00:47:10,150
+الحركة العقلية ترتفع من 4.3 إلى 7.2 وهذا يجعل الـ
+
+631
+00:47:10,150 --> 00:47:13,830
+sperm أكثر قدرة على البقاء وبكسب قدرة على الحركة
+
+632
+00:47:13,830 --> 00:47:17,150
+بقولك بعد الـ ejaculation ووصول الحركة الحركة
+
+633
+00:47:17,150 --> 00:47:20,710
+العقلية إلى أعلى جزء الحركة عقلية مقابل الحركة
+
+634
+00:47:20,710 --> 00:47:27,420
+العقلية مباشرةاحسب عشر ثواني تبدأ البيئة الخاصة
+
+635
+00:47:27,420 --> 00:47:31,340
+بالفيجاينال بـH تتغير فتصبح من خمسة إلى سبعة
+
+636
+00:47:31,340 --> 00:47:35,700
+واثنين وهي عبارة عن بيئة مناسبة لبقاء ال sperm
+
+637
+00:47:35,700 --> 00:47:39,760
+واكتسابه قدرة على الحركة يعني كأنه بتفعل عملية
+
+638
+00:47:39,760 --> 00:47:43,720
+الحركة لل sperm بتصير ال sperm عنده قدرة ورغبة في
+
+639
+00:47:43,720 --> 00:47:48,260
+الحركة بدل ما كان عنده غير قادر على الحركة وممكن
+
+640
+00:47:48,260 --> 00:47:52,540
+يصيله destruction بشكل او باخرالـ optimal pH للـ
+
+641
+00:47:52,540 --> 00:48:00,020
+sperm motility تقدر من 6 ل 6.5 6 ل 6.5 خلال دقائق
+
+642
+00:48:00,020 --> 00:48:03,080
+بعد دخول الفجاية .. ده دخول الـ semen للفجاية
+
+643
+00:48:03,080 --> 00:48:07,380
+الخاصة بالفمان الـ human semen will be coagulated
+
+644
+00:48:07,380 --> 00:48:11,760
+into loose gel شو يعني loose gel؟ أن الـ semen
+
+645
+00:48:11,760 --> 00:48:16,420
+بيكون عبارة عن كتل بفعل عمليات التجلط الموجودة فيه
+
+646
+00:48:16,420 --> 00:48:20,060
+طبعا هذه التجلطات الموجودة بتحميهخلال انتقاله من
+
+647
+00:48:20,060 --> 00:48:24,740
+الـ Reproductive Tract للألمان وصولا إلى الـ
+
+648
+00:48:24,740 --> 00:48:28,620
+Cervic طبعا بيبدأ هذا الكواجوليت يسيله عملية إذابة
+
+649
+00:48:28,620 --> 00:48:32,380
+علشان يتحرر ال sperm إيش يعني إذابة؟ الكواجوليت
+
+650
+00:48:32,380 --> 00:48:36,920
+عبارة عن شبكة تحمل ال sperm من أي خطر ممكن يواجهه
+
+651
+00:48:36,920 --> 00:48:41,170
+خلال عملية الانتقال وعلشان ال sperm يتحررويبدأ
+
+652
+00:48:41,170 --> 00:48:46,270
+يتحرك، لازم يصير تفكك لهذا الخيوط تحت حاجة نسميها
+
+653
+00:48:46,270 --> 00:48:53,530
+«Lose the Gel» «الكواجولان» يحمي الـ Spam من مجال
+
+654
+00:48:53,530 --> 00:48:56,930
+الـ «ميكروعينفيرومنت» الـ Harsh Vaginal ويمكن
+
+655
+00:48:56,930 --> 00:49:00,450
+أيضًا تحمي الـ Spam قريبًا من الـ Serum إيش وظيفة
+
+656
+00:49:00,450 --> 00:49:04,470
+الكواجولان أو التجلطات أو التخثرات الموجودة في الـ
+
+657
+00:49:04,470 --> 00:49:10,520
+seminal؟ هي عبارة عن عوامل تحميالـ sperm من أي up
+
+658
+00:49:10,520 --> 00:49:16,180
+-normality موجودة في الفيجاينة و تعمل على إيصال ال
+
+659
+00:49:16,180 --> 00:49:21,600
+sperm إلى طرف ال cervical بكفاءة عالية و بدرجة
+
+660
+00:49:21,600 --> 00:49:27,240
+عالية من الأمام
+
+661
+00:49:27,240 --> 00:49:31,840
+سوف نتقف على هذا الحد في مهدد المحاضرة على أمل أن
+
+662
+00:49:31,840 --> 00:49:36,100
+نكمل في المحاضرة القادمة ان شاء الله أرجو أن
+
+663
+00:49:36,100 --> 00:49:39,010
+تكونوا دائما بخيرتروح القوم
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/Z4YwVN8UPs8_postprocess.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/Z4YwVN8UPs8_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..e4ceb19183084f58933b722165b705e63887dacd
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/Z4YwVN8UPs8_postprocess.srt
@@ -0,0 +1,2700 @@
+1
+00:00:01,530 --> 00:00:05,430
+بسم الله الرحمن الرحيم الصلاة والسلام على أشرف
+
+2
+00:00:05,430 --> 00:00:10,270
+المرسلين سيدنا محمد الصادق الأمين أما بعد بداية
+
+3
+00:00:10,270 --> 00:00:14,090
+أراحب بكم جميعا جديد وأرجو من الله الكريم أن
+
+4
+00:00:14,090 --> 00:00:18,960
+تكونوا جميعا بخير و بصحة جيدةفي المحاضرة السابقة
+
+5
+00:00:18,960 --> 00:00:23,680
+تطرحنا إلى عدة نقاط أهمها الـ infertility problem
+
+6
+00:00:23,680 --> 00:00:29,040
+تعريف ال infertility كيف تصنف ال infertility هل
+
+7
+00:00:29,040 --> 00:00:34,060
+تعتبر ال infertility أو التأثر في الإنجاب مشكلة
+
+8
+00:00:34,060 --> 00:00:39,680
+يعاني منها جميع الناس أم فيها معينة تحدثنا عن
+
+9
+00:00:39,680 --> 00:00:43,320
+أسباب ال infertility عند ال male و عند ال female
+
+10
+00:00:43,320 --> 00:00:48,490
+تحدثنا عن العوامل التي تؤثرعلى ال fertility أي
+
+11
+00:00:48,490 --> 00:00:52,270
+الخصوبة عند ال male و عند ال female و فيما سابق
+
+12
+00:00:52,270 --> 00:00:58,210
+تحدثنا عن ال IVF و تحدثنا عن ال IGC كانوك ذا بسيطة
+
+13
+00:00:58,210 --> 00:01:05,110
+عنه و توقفنا عند مصطلح جديد كيف يمكن الحصول على
+
+14
+00:01:05,110 --> 00:01:12,780
+baby أو كيف يمكن الحصول على حالة من الإنجابتحت
+
+15
+00:01:12,780 --> 00:01:18,140
+عنوان getting ready for pregnancy كيف يحدث الحميد
+
+16
+00:01:18,140 --> 00:01:24,760
+عند ال female وكيف يساهم نطف الرجل أو ال male على
+
+17
+00:01:24,760 --> 00:01:28,720
+الإتجار هنتكلم هلأ عدة أمور هنتكلم على ال
+
+18
+00:01:28,720 --> 00:01:33,780
+spermogenesis هنتكلم عن ال oogenesis كتعريفهم
+
+19
+00:01:33,780 --> 00:01:39,750
+أحداث بتصير في كلا العمليتين كيفتساهم عملية الـ
+
+20
+00:01:39,750 --> 00:01:43,770
+sperm metagenesis والتخليق النطف الذكرية في الحصول
+
+21
+00:01:43,770 --> 00:01:50,370
+على sperm mature قادر أن يلطح بويضة ناضجة هذه
+
+22
+00:01:50,370 --> 00:01:54,530
+البويضة تتحول إلى جنين، هذا الجنين يصبح
+
+23
+00:01:54,530 --> 00:02:00,240
+implementation في جدار الرحم للوصول إلىمولود كامل
+
+24
+00:02:00,240 --> 00:02:05,780
+بعد تسعة شهور أو سبعة شهور يناير على الحالة الخاصة
+
+25
+00:02:05,780 --> 00:02:11,600
+بالأنثى أو السيدة في نقاط بسيطة ان شاء الله سنتكلم
+
+26
+00:02:11,600 --> 00:02:17,500
+عن getting pregnancy بداية عملية ال pregnancy ليست
+
+27
+00:02:17,500 --> 00:02:22,200
+عملية سهلة بل هي عبارة عن عملية معقدة جدا جدا جدا
+
+28
+00:02:22,200 --> 00:02:27,240
+تمر بعدة مراحل و عدة أحداث و يشارك فيها الرجل
+
+29
+00:02:27,720 --> 00:02:32,780
+وتشارك فيها السيدة كلًا بجاميطته المقصود
+
+30
+00:02:32,780 --> 00:02:36,300
+بالجاميطات ال female gametes هي عبارة عن ال oocyte
+
+31
+00:02:36,300 --> 00:02:42,020
+و لازم تكون ضمن صفات معينة ومواصفات معينة حتى ضمن
+
+32
+00:02:42,020 --> 00:02:46,400
+Diameter معين وجاميطات الذكر اللي بنسميها male
+
+33
+00:02:46,400 --> 00:02:49,400
+gametes هي عبارة عن ال sperm و هذا ال sperm لازم
+
+34
+00:02:49,400 --> 00:02:53,600
+يكون completely normal أو بنسبة معينة طبعًا لما
+
+35
+00:02:53,600 --> 00:02:56,700
+نقول normal لما نحكي عن ال sperm من حيث ال
+
+36
+00:02:56,700 --> 00:02:59,760
+morphologyأما لحكي على الـ semen و هنتكلم عنه بشكل
+
+37
+00:02:59,760 --> 00:03:04,260
+مستفيد لازم يكون normal من حيث الـ count من حيث ال
+
+38
+00:03:04,260 --> 00:03:08,940
+motility و من حيث ال morphology علشان يصير في عنده
+
+39
+00:03:08,940 --> 00:03:12,880
+pregnancy و ال pregnancy should be pigance لازم
+
+40
+00:03:12,880 --> 00:03:17,240
+يصير عنده fusion ما بين ال sperm ال خاص بال male
+
+41
+00:03:17,240 --> 00:03:21,900
+مع ال oocyte الخاصة بال female وهذه عملية ال
+
+42
+00:03:21,900 --> 00:03:26,550
+fusion أو ال fertilization بالمصطلح العلميتحدث في
+
+43
+00:03:26,550 --> 00:03:29,730
+منطقة معينة من ال reproductive system عند الفيميل
+
+44
+00:03:29,730 --> 00:03:34,090
+وهي عبارة عن ال fallopian tube او reproductive
+
+45
+00:03:34,090 --> 00:03:38,810
+tract اذا صار في عندي fusion يعني صار في عندي اول
+
+46
+00:03:38,810 --> 00:03:42,910
+خطوة من خطوات ال pregnancy وعلشان يصير في عندي
+
+47
+00:03:42,910 --> 00:03:47,270
+pregnancy لازم يصير عندي steps اول حاجة both male
+
+48
+00:03:47,270 --> 00:03:51,290
+and female sex cell should be or must be passed
+
+49
+00:03:51,290 --> 00:03:57,310
+through a longseries of exchanges وهي اللي بنسميها
+
+50
+00:03:57,310 --> 00:04:01,510
+gematogenesis بمعنى أخر أنه أنا عندي male gemats و
+
+51
+00:04:01,510 --> 00:04:05,130
+female gemats هذه ال male و ال female gemats لازم
+
+52
+00:04:05,130 --> 00:04:08,810
+أنه يصير فيها عملية maturation للوصول إلى ال
+
+53
+00:04:08,810 --> 00:04:13,030
+formula أو ال form اللي بسمح لها بعملية التلقيح
+
+54
+00:04:13,030 --> 00:04:18,230
+هذه ال exchange اللي بتصير بنسميها mutagenesis أي
+
+55
+00:04:18,230 --> 00:04:23,820
+تخليق الجامتات تخليق عفوا بنسميهاGermetogenesis هي
+
+56
+00:04:23,820 --> 00:04:27,940
+عبارة عن تخليق الجميطات تسميها Germetogenesis وهي
+
+57
+00:04:27,940 --> 00:04:33,160
+عبارة عن عملية يتم فيها تحويل وتخليق الجميطات ولكي
+
+58
+00:04:33,160 --> 00:04:36,420
+تخلق الجميطات ال male و ال female germetes لازم
+
+59
+00:04:36,420 --> 00:04:40,660
+يصير في عندك convert لهم في ال genetic material في
+
+60
+00:04:40,660 --> 00:04:46,020
+الفينو تبقى structure عشان تصل لمثيور جميط وإذا
+
+61
+00:04:46,020 --> 00:04:50,580
+وصلت لمثيور جميط معناها سوف تكون قادرة حتما على ال
+
+62
+00:04:50,580 --> 00:04:54,500
+fertilizationبشرط أن تكون Normal من حيث الـ
+
+63
+00:04:54,500 --> 00:04:57,420
+Function لأن في عندي بعض الجميطات زي الـ Oocyte
+
+64
+00:04:57,420 --> 00:05:03,140
+جميط أو الـ spermatozoite أو الـ spermatozoa أو
+
+65
+00:05:03,140 --> 00:05:08,480
+الـ sperm بتكون phylotypically normal ولكن
+
+66
+00:05:08,480 --> 00:05:12,020
+functional abnormal فما بتقدر تعمل ال
+
+67
+00:05:12,020 --> 00:05:15,240
+fertilization هذه ال spermatozoa أو ال oocyte ما
+
+68
+00:05:15,240 --> 00:05:19,640
+بتقدر تستمر بعد عملية ال fertilization هذه إذا
+
+69
+00:05:19,640 --> 00:05:23,910
+كانت functionalغير طبيعية المرحلة التانية من
+
+70
+00:05:23,910 --> 00:05:29,070
+المراحل وهي عبارة عن بعد عملية الـ Gematogenesis
+
+71
+00:05:29,070 --> 00:05:34,370
+عملية التخليق لازم هذه الجميطات تنتقل من مكان
+
+72
+00:05:34,370 --> 00:05:38,770
+التخليق إلى مكان النضوج فبالتالي نستطيع أن نستوعب
+
+73
+00:05:38,770 --> 00:05:42,330
+و نفهم شيء هنا أن الـ place of production should
+
+74
+00:05:42,330 --> 00:05:45,290
+be separated from the place of storage and
+
+75
+00:05:45,290 --> 00:05:49,330
+saturation فبالتالي معناه أن الجميطات تخلق في مكان
+
+76
+00:05:49,800 --> 00:05:54,740
+وتنضج في مكان وتخصط في مكان آخر أو تستخدم في
+
+77
+00:05:54,740 --> 00:05:59,800
+التقسيد في مكان آخر فلو أنا أجهز على سبيل مثال على
+
+78
+00:05:59,800 --> 00:06:05,300
+الجناد الخاصة أو الـ Gematocyte الخاصة بالفيميل
+
+79
+00:06:05,300 --> 00:06:10,180
+حلاجيها تخلق في ال ovary و بيصير لها maturation في
+
+80
+00:06:10,180 --> 00:06:13,440
+ال ovary ولكن بيصير لها fertilization في ال
+
+81
+00:06:13,440 --> 00:06:17,400
+fallopian tube فبالتالي مكان ال maturation حتى في
+
+82
+00:06:17,400 --> 00:06:20,870
+ال ovary مكان ال maturationيختلف عن مكان الـ
+
+83
+00:06:20,870 --> 00:06:24,610
+formation لو أنا أتكلمت على الـ spermatocyte
+
+84
+00:06:24,610 --> 00:06:28,210
+هلاجيها تخلق في الـ testis وتنضج في الـ embedded
+
+85
+00:06:28,210 --> 00:06:32,510
+muscle وهو جوز من الـ testis تخلق في منطقة في الـ
+
+86
+00:06:32,510 --> 00:06:36,750
+testis، عن كلام أنا بالصورة و ثم بعد ذلك بيصيرها
+
+87
+00:06:36,750 --> 00:06:42,230
+ejaculation خارج جسم الإنسان علشان تستخدم في عملية
+
+88
+00:06:42,230 --> 00:06:46,170
+تلقيح البويضة الناضجة بـ fallopian tube هذه رحلة
+
+89
+00:06:46,170 --> 00:06:51,470
+طويلة جدايتم فيها انتقال ال sperm من ال male إلى
+
+90
+00:06:51,470 --> 00:06:54,370
+ال female لتلقح البقايدة واحنا نتكلم عنها بشكل
+
+91
+00:06:54,370 --> 00:06:57,890
+واضح جدا طب ليش هنتكلم عن هذا الموضوع؟ لأنه لازم
+
+92
+00:06:57,890 --> 00:07:01,790
+نفهم ال gematogenesis كيف تخلّح أي خلل في تخليق
+
+93
+00:07:01,790 --> 00:07:06,030
+الجمهيطات معناه فشل في ال fertilization فشل في ال
+
+94
+00:07:06,030 --> 00:07:11,990
+fertilization يعني غير .. غير قادرين على الحصول
+
+95
+00:07:11,990 --> 00:07:17,720
+على حالة من حالة pregnancyبالنسبة للموضوع الواضح
+
+96
+00:07:17,720 --> 00:07:23,940
+أن الوضع
+
+97
+00:07:23,940 --> 00:07:26,820
+يتنصف بالنسبة للموضوع الواضح ان الوضع يتنصف
+
+98
+00:07:26,820 --> 00:07:26,920
+بالنسبة للموضوع الواضح ان الوضع يتنصف بالنسبة
+
+99
+00:07:26,920 --> 00:07:26,980
+للموضوع الواضح ان الوضع يتنصف بالنسبة للموضوع
+
+100
+00:07:26,980 --> 00:07:28,800
+الواضح ان الوضع يتنصف بالنسبة للموضوع الواضح ان
+
+101
+00:07:28,800 --> 00:07:30,520
+الوضع يتنصف بالنسبة للموضوع الواضح ان الوضع يتنصف
+
+102
+00:07:30,520 --> 00:07:33,320
+بالنسبة للموضوع الواضح ان الوضع يتنصف بالنسبة
+
+103
+00:07:33,320 --> 00:07:37,100
+للموضوع الواضح ان الوضع يتنصف بالنسبة للموضوع
+
+104
+00:07:37,100 --> 00:07:42,970
+الواضح ان الوأي Oocyte بعد عملية التخصيب لازم
+
+105
+00:07:42,970 --> 00:07:47,650
+تُنقل بفعل السيليا على سبيل المثال بفعل القبضات
+
+106
+00:07:47,650 --> 00:07:51,510
+للعضلات اللي خاصة بال reproductive tract و ال
+
+107
+00:07:51,510 --> 00:07:54,870
+fallopian tube تنتقل من منطقة التلطيح و هي
+
+108
+00:07:54,870 --> 00:07:59,210
+fallopian tube فنشوف صورة في هذه عملية التلطيح
+
+109
+00:07:59,210 --> 00:08:02,970
+البويضة animation من منطقة التلطيح fallopian tube
+
+110
+00:08:02,970 --> 00:08:07,150
+إلى الرحم لكي تنغرز في بطارية الرحم تحت مصطلح
+
+111
+00:08:07,150 --> 00:08:13,420
+بتسميهimplantation هو عبارة عن انغراس أو الانغماس
+
+112
+00:08:13,420 --> 00:08:17,120
+فبصير في عندي انغماس البويضة الملقح في بطانة الرحم
+
+113
+00:08:17,120 --> 00:08:21,200
+والأم فيما بعد بتمدها أو الدورة الدموية الخاصة
+
+114
+00:08:21,200 --> 00:08:24,360
+بالأم بتمدها بكل المواد الغذائية لتكوين ال
+
+115
+00:08:24,360 --> 00:08:29,900
+placenta التي تعتبر مصدر ومدخل للغذاء ال
+
+116
+00:08:29,900 --> 00:08:33,760
+gematogenesis هل هي عبارة عن حدث واحد فقط لغير one
+
+117
+00:08:33,760 --> 00:08:37,960
+event one step ولا في different stepوهل ال male و
+
+118
+00:08:37,960 --> 00:08:41,780
+female gematogenesis مختلفين؟ أكيد مختلفين، لكن
+
+119
+00:08:41,780 --> 00:08:45,700
+لكي نبسط المعلومة، بما نستطيع أن نقول إن ال male
+
+120
+00:08:45,700 --> 00:08:50,100
+gematogenesis similar with male female
+
+121
+00:08:50,100 --> 00:08:55,680
+gematogenesis في only one phase هل هناك أطوار
+
+122
+00:08:55,680 --> 00:08:59,540
+أخرى؟ أكيد في عندي أربع أطوار أو أربع مراحل لتكوين
+
+123
+00:08:59,540 --> 00:09:03,380
+ال gematocyte أو ال gematogenesis العملية المرحلة
+
+124
+00:09:03,380 --> 00:09:07,500
+الأولى بنسميها extra-emperionic originalأو origin
+
+125
+00:09:07,500 --> 00:09:11,600
+of the germ cell and their migration into gonads
+
+126
+00:09:11,600 --> 00:09:17,180
+وهي عبارة عن عملية يتم فيها تخليق الجميطات في ال
+
+127
+00:09:17,180 --> 00:09:20,920
+embryo اللي بنسميها extra embryonic ليش سموها
+
+128
+00:09:20,920 --> 00:09:25,380
+extra embryonic؟ لأنها بتحدث خارج أو قبل تكوين ال
+
+129
+00:09:25,380 --> 00:09:29,640
+embryo بالشكل اللي احنا بنعرفه ثم بعد ذلك يتم
+
+130
+00:09:29,640 --> 00:09:34,320
+نقلها إلى منطقة الجناد في ناس تعرفها بمنطق أخر هي
+
+131
+00:09:34,320 --> 00:09:38,240
+عبارة .. بمنطق أخر هي عبارة عنتصنيع الجميطات في
+
+132
+00:09:38,240 --> 00:09:42,940
+غير مكانها يعني المفروض الجميل كالـ sperm يُصنع في
+
+133
+00:09:42,940 --> 00:09:46,660
+الـ testis وكالـ oocyte تُصنع في الـ ovary ولكن
+
+134
+00:09:46,660 --> 00:09:51,140
+أول مرحلة بنتسموها extra-embryonic وهي عبارة عن
+
+135
+00:09:51,140 --> 00:09:55,500
+عملية يتم فيها تصنيع الجميطات خارج منطقة الجنادى
+
+136
+00:09:55,500 --> 00:09:58,380
+الجنادى اللي بنتسميه ال reproductive system للـ
+
+137
+00:09:58,380 --> 00:10:02,000
+male أو reproductive system لل female ال ovary و
+
+138
+00:10:02,000 --> 00:10:06,450
+ال testis هذه المرحلة الأولىوهذه المرحلة تتشابه
+
+139
+00:10:06,450 --> 00:10:09,990
+عند الـ Male وعند الـ Female يليها ثلاث مراحل،
+
+140
+00:10:09,990 --> 00:10:13,610
+المرحلة التانية زيادة في عدد الـ Germ Cypin
+
+141
+00:10:13,610 --> 00:10:18,750
+استخدام انقسم ميتوزي يليه reduction in the
+
+142
+00:10:18,750 --> 00:10:22,530
+chromosome number في الـ Female والمال تحت انقسم
+
+143
+00:10:22,530 --> 00:10:26,370
+ميوزي وآخر الـ phase بنسميه Structural and
+
+144
+00:10:26,370 --> 00:10:30,130
+Functional Maturation of Oocyte and Sperm أربع
+
+145
+00:10:30,130 --> 00:10:35,380
+step الأولى هي عبارة عن تخليق الجميطخارج منطقة
+
+146
+00:10:35,380 --> 00:10:40,440
+الجونات بالسمية Extra-Empirionic Origin وهي تتشابه
+
+147
+00:10:40,440 --> 00:10:44,760
+عند الذكر والأنثى الـ three step الأخيرة تختلف عند
+
+148
+00:10:44,760 --> 00:10:48,460
+الذكر عن الأنثى وهي عبارة عن increase in the
+
+149
+00:10:48,460 --> 00:10:52,580
+number of germ cell من القسم الميتوزي reduction in
+
+150
+00:10:52,580 --> 00:10:55,840
+the chromosome number من القسم الميوزي بعدين
+
+151
+00:10:55,840 --> 00:10:59,020
+structural and functional macuration of oocyte
+
+152
+00:10:59,020 --> 00:11:04,700
+بأكد مرة أخرى أن التلتخطوات الأخيرة تختلف عند ال
+
+153
+00:11:04,700 --> 00:11:08,760
+male و عند ال female بينما الخطوة الأولى متشابهة
+
+154
+00:11:08,760 --> 00:11:13,160
+عند الذكر و المنتقل نيجي الخطوة خطوة الخطوة الأولى
+
+155
+00:11:13,160 --> 00:11:17,920
+اللى سمناها extra embryonic origin and migration
+
+156
+00:11:17,920 --> 00:11:23,520
+of germ cell to the gonadal place في خلاية بنسميها
+
+157
+00:11:23,520 --> 00:11:27,640
+الخلاية الأم زى الخلاية ال stem cell في خلاينا
+
+158
+00:11:27,640 --> 00:11:31,690
+جميعا في خلاية أم بنسميها stem cell ولكنالخلية
+
+159
+00:11:31,690 --> 00:11:36,130
+الأم الخاصة بالجميد عند الميل وعند الفيميل بسميها
+
+160
+00:11:36,130 --> 00:11:41,450
+PGS Primordial Germ Cell من اسم الجيرم سيل ولكن
+
+161
+00:11:41,450 --> 00:11:45,150
+ضافوا لها Primordial لإنها خلية الأم هذه الخلية
+
+162
+00:11:45,150 --> 00:11:48,170
+الأم اللي بتسميها Primordial Germ Cell واختصارها
+
+163
+00:11:48,170 --> 00:11:53,390
+PGS هي عبارة عن الخلية الأولى التي تظهر خلال عملية
+
+164
+00:11:53,390 --> 00:11:57,510
+تكوين الجميد فبنسميها Precursor Cell for Gemid
+
+165
+00:11:57,510 --> 00:12:01,930
+Formation أو Precursor Cell for Gemidهذه الخلايا
+
+166
+00:12:01,930 --> 00:12:07,610
+الـ BGS تظهر خارج الجناد وبعد أن تتكافر بأعداد
+
+167
+00:12:07,610 --> 00:12:11,930
+مناسبة بيصيرها migration لمنطقة الجناد وهذه
+
+168
+00:12:11,930 --> 00:12:15,870
+العملية بتصير في ال early embryonic development في
+
+169
+00:12:15,870 --> 00:12:21,930
+ال early embryonic development وهي أول شهور الحمل
+
+170
+00:12:21,930 --> 00:12:27,010
+على سبيل المثال حمل الذكر أو أنثى طبعا بيصير في
+
+171
+00:12:27,010 --> 00:12:32,680
+عين ديprimordial germ cell تبدأ تظهر في منطقة خارج
+
+172
+00:12:32,680 --> 00:12:37,900
+الجونات ثم عندما تكثر من حيث العدد تنتقل إلى منطقة
+
+173
+00:12:37,900 --> 00:12:41,800
+الجونات human primordial germ cell first become
+
+174
+00:12:41,800 --> 00:12:47,720
+pretty recognizable at 24 days after fertilization
+
+175
+00:12:47,720 --> 00:12:52,420
+يعني ببدأ أتعرف على هذه ال primordial germ cell
+
+176
+00:12:52,420 --> 00:12:56,590
+بعد 24 يوم من ال fertilizationلو صار فيها في عندي
+
+177
+00:12:56,590 --> 00:13:00,830
+fertilization aid 1,2,3 لحد اليوم الـ 24 بعد اليوم
+
+178
+00:13:00,830 --> 00:13:05,690
+الـ 24 تبدأ primordial germ cell تظهر و ببدأ أنا
+
+179
+00:13:05,690 --> 00:13:10,450
+أتعرف عليها in the endodermal layer of yolk sac
+
+180
+00:13:10,450 --> 00:13:14,570
+يوكساك زي المحي، بنسميه المحي من اللغة العربية
+
+181
+00:13:14,570 --> 00:13:18,190
+طبعا بتكون في ال size .. من حيث ال size very large
+
+182
+00:13:18,190 --> 00:13:22,940
+بتحتوي هذه الخلايا على كمية كبيرة جدامن الجليكوجين
+
+183
+00:13:22,940 --> 00:13:26,320
+وبعض الإنزيمات زي الـAlkaline Phosphatase طبعا هذا
+
+184
+00:13:26,320 --> 00:13:29,240
+الجليكوجين بيحافظ على شكله و بيحميها والAlkaline
+
+185
+00:13:29,240 --> 00:13:32,960
+Phosphatase بيلعب دور كبير جدا في الـmetabolic ال
+
+186
+00:13:32,960 --> 00:13:36,680
+process الخاصة بهذا الخلايا طبعا عملوا دراسة على
+
+187
+00:13:36,680 --> 00:13:40,760
+الماوس كمديول وجدوا أن فيه عنده حوالي 100 cell
+
+188
+00:13:40,760 --> 00:13:44,540
+موجودة أو تغادر، خلّيني أسمي الـyolk sac 100 cell
+
+189
+00:13:44,540 --> 00:13:48,730
+من الـprimordial germ cell تغادر اليوكساكوبتخضع
+
+190
+00:13:48,730 --> 00:13:51,150
+لانقسام الميتوزي المتكرر بيصير عندنا
+
+191
+00:13:51,150 --> 00:13:56,630
+multiplication حوالي 6 إلى 7 مرات الميت خلية بتصل
+
+192
+00:13:56,630 --> 00:14:01,210
+إلى 4000 خلية من حيث العدد وهذه بتسميها 4000
+
+193
+00:14:01,210 --> 00:14:04,630
+primordial germ cells will be entered the
+
+194
+00:14:04,630 --> 00:14:09,890
+embryonic colon هذه الميت خلية من دراسة حدثت على
+
+195
+00:14:09,890 --> 00:14:13,310
+الفقران وجدوا ان ميت خلية من ال primordial germ
+
+196
+00:14:13,310 --> 00:14:18,240
+cell موجودةفي هذه المنطقة أو تنتقل خلّيني أسميها
+
+197
+00:14:18,240 --> 00:14:22,540
+من منطقة اليوكساك إلى منطقة الجناد ولكن قبل أن
+
+198
+00:14:22,540 --> 00:14:27,080
+تنتقل لازم تخضع إلى المقسام الميتوزي حوالي 7 مرات
+
+199
+00:14:27,080 --> 00:14:32,940
+عشان يصل عددها إلى 4000 خلية هذه ال 4000 خلية هي
+
+200
+00:14:32,940 --> 00:14:37,020
+اللي بتدخل في منطقة ال embryonic جناد اللي بتسميها
+
+201
+00:14:37,020 --> 00:14:42,220
+primitive أو embryonic جناد علشان تبدأ صنع الجناد
+
+202
+00:14:43,460 --> 00:14:46,800
+عشان تبدأ تصنع الجناد الخاصة بالـ membrane تيجي
+
+203
+00:14:46,800 --> 00:14:49,300
+المرحلة التانية، طبعا هذه المرحلة similar in male
+
+204
+00:14:49,300 --> 00:14:52,540
+and female المرحلة التانية هي increasing the
+
+205
+00:14:52,540 --> 00:14:56,180
+number of germ cell by mitosis بعد ما تصل
+
+206
+00:14:56,180 --> 00:14:59,640
+لـprimordial germ cell الأربع ثلاث خلية، تصل
+
+207
+00:14:59,640 --> 00:15:03,960
+للجناد، primordial germ cell begin a phase of
+
+208
+00:15:03,960 --> 00:15:07,180
+rapidly mitotic proliferationأول ما تصل
+
+209
+00:15:07,180 --> 00:15:10,900
+الـprimordial germ cell إلى الجنات تبدأ في عملية
+
+210
+00:15:10,900 --> 00:15:14,720
+الانقسام الميتوزي المتكرر عشان يزيد العدد لأن
+
+211
+00:15:14,720 --> 00:15:18,220
+الورق في الأرض مش هيكوفن فبالتالي لازم يصير زيادة
+
+212
+00:15:18,220 --> 00:15:20,960
+في العدد زيادة في العدد معناه أنه لازم يصير في
+
+213
+00:15:20,960 --> 00:15:24,300
+عنده انقسام ميتوزي وعارفين أن انقسام الميتوزي من
+
+214
+00:15:24,300 --> 00:15:27,620
+المحاضرة السابقة ومن المعلومات السابقة اللي كنا
+
+215
+00:15:27,620 --> 00:15:31,140
+بنعرفها أن كل خلية بتدخل في انقسام الميتوزي تعطي
+
+216
+00:15:31,140 --> 00:15:36,770
+خليتين identical بنسميهم two daughter cellsفي الـ
+
+217
+00:15:36,770 --> 00:15:41,590
+Mitotic Division، كل خلية تعطي 2 diploid progen
+
+218
+00:15:41,590 --> 00:15:44,910
+that are genetically equal، عشان كده بنسميهم
+
+219
+00:15:44,910 --> 00:15:47,930
+daughter cells، تبقى إيش يعني diploid؟ يعني فيها
+
+220
+00:15:47,930 --> 00:15:51,610
+أزواج من الكروموزوم، إذا كان أنا في الخلية الأصلية
+
+221
+00:15:51,610 --> 00:15:54,710
+فيها عند اتنين كروموزوم، فبتعطيني خليتين كل خلية
+
+222
+00:15:54,710 --> 00:15:58,390
+فيها اتنين كروموزوم، diploid، الـ diploid منصف
+
+223
+00:15:58,390 --> 00:16:04,960
+لعدد الكروموزومطبعا بعد انقسام ميتوزي بشكل مستمر
+
+224
+00:16:04,960 --> 00:16:08,700
+وبشكل متتالي للـPrimordial Germ Cell اتصل من
+
+225
+00:16:08,700 --> 00:16:12,660
+hundred أو thousand إلى مليون لأن وجودنا مية خلية
+
+226
+00:16:12,660 --> 00:16:16,800
+في الفئران انقسموا انقسام ميتوزي ووصلوا أربع تلاف
+
+227
+00:16:16,800 --> 00:16:19,300
+للأربع تلاف انتقلوا إلى الـPrimordial Germ Cell
+
+228
+00:16:19,300 --> 00:16:21,740
+إلى الـGonad Place اللي بيسميها Embryonic Gonad
+
+229
+00:16:21,740 --> 00:16:25,220
+طبعا هذه تستمر في انقسام الميتوزي عشان اتصل
+
+230
+00:16:25,220 --> 00:16:28,950
+الملايين الخلاياهل هي الـ Primordial Germ Cell لها
+
+231
+00:16:28,950 --> 00:16:31,850
+علاقة بالـ Oocyte و الـ Spermatocyte؟ أكيد عشان
+
+232
+00:16:31,850 --> 00:16:34,690
+كده لازم تصير ملايين عشان هتخدم ال male و ال
+
+233
+00:16:34,690 --> 00:16:37,730
+female طيلة فترة حياته من الخمسين أو الستين أو
+
+234
+00:16:37,730 --> 00:16:41,810
+السمعين سنة طبعا في الـ Mitotic Preliberation في
+
+235
+00:16:41,810 --> 00:16:44,650
+بعض ال different mark عند ال male و عند ال female
+
+236
+00:16:44,650 --> 00:16:48,710
+germ cell هنتكلم عنها يعني كيف ال male بتختلف عن
+
+237
+00:16:48,710 --> 00:16:51,850
+ال female أو كيف ال male يختلف عن ال female في
+
+238
+00:16:51,850 --> 00:16:55,610
+الإنقسام الميتوذي هنتكلم عنه في mark معين و site
+
+239
+00:16:55,610 --> 00:17:01,720
+معينبداية الـ mitotic active germ cell في الفيميل
+
+240
+00:17:01,720 --> 00:17:06,220
+بنسميها Ogonia يعني الخلايا اللي دخلت القسم
+
+241
+00:17:06,220 --> 00:17:11,200
+الميتوزي عند الفيميل وصارت بالملايين بسميها Ogonia
+
+242
+00:17:11,200 --> 00:17:16,500
+which is going through a period of mitotic
+
+243
+00:17:16,500 --> 00:17:19,840
+activity in the embryonic ovary from the second
+
+244
+00:17:19,840 --> 00:17:24,280
+throat to the fifth mouth of pregnancy in the
+
+245
+00:17:24,280 --> 00:17:28,330
+humanاللي بتفهمه من هذه الإبارة إن الـ Ogonia
+
+246
+00:17:28,330 --> 00:17:34,050
+تستمر في الإنقسام الميتوزي من الشهر التاني لعمر
+
+247
+00:17:34,050 --> 00:17:38,210
+الجنين حتى الشهر الخامس بعد كده مافيش حاجة اسمها
+
+248
+00:17:38,210 --> 00:17:41,750
+Ogonia أو بمعنى آخر بعد كده بتتوقف الإنقسام
+
+249
+00:17:41,750 --> 00:17:45,290
+الميتوزي إذا بالنسبة لل female وهذا أول نقاط
+
+250
+00:17:45,290 --> 00:17:49,090
+الإختلاف ما بين ال male و ال female في الحدث
+
+251
+00:17:49,090 --> 00:17:54,100
+التاني أو ال phase التانيمن تكوين الجميطات إن الـ
+
+252
+00:17:54,100 --> 00:17:59,520
+Female تستمر عملية الانقسام الميتوزي بشكل تبدأ في
+
+253
+00:17:59,520 --> 00:18:03,240
+الشهر الثاني من الحمل أو الشهر الثاني من عمر
+
+254
+00:18:03,240 --> 00:18:08,000
+الجنين حتى الشهر الخامس يعني بمجرد الجنين يدخل
+
+255
+00:18:08,000 --> 00:18:11,720
+الشهر الخامس الانقسام الميتوزي إذا كان الجنين
+
+256
+00:18:11,720 --> 00:18:18,580
+Female بتوقف هذه النقطة الأولى طيب بالنسبة ل ..
+
+257
+00:18:18,580 --> 00:18:22,830
+أنا خلصت بالنسبة لنقطة الأولىطبعا خلال هذه الشهرين
+
+258
+00:18:22,830 --> 00:18:26,810
+إلى خمس شهور الـ Primordial Germ Cell بزيد عددها
+
+259
+00:18:26,810 --> 00:18:30,470
+بشكل كبير جدا تصل إلى ملايين تصل عند ال female
+
+260
+00:18:30,470 --> 00:18:35,230
+تقريبا سبعة مليون خلية هذه سبعة مليون خلية هيتطور
+
+261
+00:18:35,230 --> 00:18:41,430
+ويعطوني سبعة مليون OocyteThe number represent the
+
+262
+00:18:41,430 --> 00:18:45,190
+maximum number of germ cells that are even bound
+
+263
+00:18:45,190 --> 00:18:49,590
+in ovary يعني هدول السبعة مليون germ cell هيتطوروا
+
+264
+00:18:49,590 --> 00:18:53,830
+إلى سبعة مليون oocyte وهي بتمثل عدد البويضات في ال
+
+265
+00:18:53,830 --> 00:18:58,230
+ovary طبعا لما أقول ovaries كل سيدة في عندها مبيض
+
+266
+00:18:58,230 --> 00:19:02,030
+على اليمين ومبيض على اليسار محصل البويضات الموجودة
+
+267
+00:19:02,030 --> 00:19:07,190
+في كل المبيضات سبعة مليون بويضة أو سبعة مليون
+
+268
+00:19:07,450 --> 00:19:11,370
+Primordial Gerbsinia طبعا ما بيبقوا 7 مليون وما
+
+269
+00:19:11,370 --> 00:19:15,310
+بيستمروا 7 مليون لإنه بيدخلوا في مراحل الاببتواسيس
+
+270
+00:19:15,310 --> 00:19:20,990
+فيما بعد طبعا خلال هذه الفترة الـ Ogonia بتدخل في
+
+271
+00:19:20,990 --> 00:19:26,590
+مرحلة بتسميها Natural Degeneration أو التدمير
+
+272
+00:19:26,590 --> 00:19:30,630
+الطبيعي إنه كل خلية إلى half-life معين بعد كده لم
+
+273
+00:19:30,630 --> 00:19:35,470
+تستعمل بصيلها تدمير بسميها هذه العملية الـ Trachea
+
+274
+00:19:35,660 --> 00:19:40,080
+إذا الـ Atresia هي عبارة عن تدمير طبيعي للـ Ogonia
+
+275
+00:19:40,080 --> 00:19:44,880
+تدمير طبيعي للـ Ogonia .. للـ Ogonia بينما الـ
+
+276
+00:19:44,880 --> 00:19:48,480
+Atresia في مرحلة تانية بتشبه الـ Menstrual Cycle
+
+277
+00:19:48,480 --> 00:19:52,380
+أو الدورة الخاصة بالسيدة لأنه مافي مقحت البويضة
+
+278
+00:19:52,380 --> 00:19:57,520
+فتنزل مع بطاقة الرحل في حالة البلد أما الـ Ogonia
+
+279
+00:19:57,520 --> 00:20:01,980
+تدخل مرحلة Apoptosis أو الـ Degeneration طبيعية
+
+280
+00:20:01,980 --> 00:20:05,360
+بسمي هذا الـ Degeneration طبيعية Atresiaطبعا
+
+281
+00:20:05,360 --> 00:20:13,160
+الاتراجيا تستمر خلال فترة حياة الأنثى من و هي جنين
+
+282
+00:20:13,160 --> 00:20:18,260
+حتى تصل مرحلة الـ monobiosis هي اتراجيا بشكل مستمر
+
+283
+00:20:18,260 --> 00:20:24,200
+و بشكل شهري و إلا كيف السيدة هتتخلص من الـ 7 مليون
+
+284
+00:20:24,200 --> 00:20:30,520
+بوايضة أو 7 مليون جرسل هذه
+
+285
+00:20:30,520 --> 00:20:34,240
+الصورة بتبين لي الاتراجيا اللي بتصير من لحظة
+
+286
+00:20:35,710 --> 00:20:40,190
+الاخصاب مرورا بلحظة الميلاد يعني الفترة الجانبية
+
+287
+00:20:40,190 --> 00:20:45,510
+مرورا بلحظة الميلاد وصولا إلى مرحلة الـ monobios
+
+288
+00:20:45,510 --> 00:20:49,850
+طبعا في عند اللون الـ yellow أو الذهبي نسميها
+
+289
+00:20:49,850 --> 00:20:54,010
+follicular pool اللون الأخضر الأتراجيا اللي بيصير
+
+290
+00:20:54,010 --> 00:20:57,190
+فيها degeneration اللون ال purple هي ال growing
+
+291
+00:20:57,190 --> 00:21:00,470
+follicle المرحلة اللي بيصير فيها تطور الخلايا و
+
+292
+00:21:00,470 --> 00:21:04,610
+اللون اللي باللون ال redأو الـ Kermidi هي عبارة عن
+
+293
+00:21:04,610 --> 00:21:06,850
+الـ ovulated follicle هي المرحلة اللي بيصل فيها
+
+294
+00:21:06,850 --> 00:21:11,230
+ovulation طبعا فيها دياجرام بيمثل ال years وبيمثل
+
+295
+00:21:11,230 --> 00:21:15,270
+ال number of germ cell خلال فترات الحياة في أول
+
+296
+00:21:15,270 --> 00:21:22,910
+فترات الحياة قبل سن الرشد أو 15 أو 16 سنة كواتبار
+
+297
+00:21:22,910 --> 00:21:27,270
+السن بيصل فيها اندي كمية كبيرة جدا من ال follicle
+
+298
+00:21:27,270 --> 00:21:31,610
+folds لأن ال follicle أو ال germ cell بتكون زي ما
+
+299
+00:21:31,610 --> 00:21:36,610
+هيفي حالة خمول وفي حالة .. زي حاجة بتسميها
+
+300
+00:21:36,610 --> 00:21:41,770
+arrested phase و بصير في هذه المرحلة atresia بشكل
+
+301
+00:21:41,770 --> 00:21:46,890
+واضح جدا لما بعد سن الرشد او مقصير adult من 20 ل
+
+302
+00:21:46,890 --> 00:21:52,030
+30 او ل 35 بلاقي انا في عندي atresia زادت بشكل
+
+303
+00:21:52,030 --> 00:21:56,710
+ملحوظ طبعا زيادة ال atresia معناه هيصير في عندي
+
+304
+00:21:56,710 --> 00:22:01,290
+نقصان في ال follicular pool عشان كده اللون الدهبي
+
+305
+00:22:01,290 --> 00:22:06,560
+بلاقيه بقلفي المقابل، سيكون في عندي Folicle Growth
+
+306
+00:22:06,560 --> 00:22:10,800
+علشان الدورة أو الـ Menstrual Cycle وفي عندي
+
+307
+00:22:10,800 --> 00:22:14,680
+Ovulated Follicle بدأت تظهر طبعا هذا العمر من 20
+
+308
+00:22:14,680 --> 00:22:22,780
+أو من 15 حتى 35 من 40 فما فوق، بلاقي كل المرحلة
+
+309
+00:22:22,780 --> 00:22:29,880
+هذه كلها Atragia كمية قليلة جدا جدا جدا هي عبارة
+
+310
+00:22:29,880 --> 00:22:33,900
+عن Ovulated Follicleلأن في هذه المرحلة، مرحلة الـ
+
+311
+00:22:33,900 --> 00:22:37,940
+post-monobiose أو الـ monobiosal مافي عندى
+
+312
+00:22:37,940 --> 00:22:41,720
+bleeding بيصير، مافي عندى menstrual cycle بيصير
+
+313
+00:22:41,720 --> 00:22:46,180
+إلا بكمية قليلة جدا في السيدات، بنسبة قليلة جدا
+
+314
+00:22:46,180 --> 00:22:50,420
+بعد الـ 40 أو بعد الـ 45 طب ليش ما بيصير في عندى
+
+315
+00:22:50,420 --> 00:22:54,180
+ovulated follicle أو ما بيصير عندى menstrual
+
+316
+00:22:54,180 --> 00:22:57,960
+cycle؟ لأن كل الـ follicle الموجودة أو ال germ
+
+317
+00:22:57,960 --> 00:23:02,350
+cell الموجودة أو القوائدات الموجودة تم استهلاكهاو
+
+318
+00:23:02,350 --> 00:23:08,050
+جزء كبير منها دخل في مرحلة الـ Atresia فبلاجي مخزن
+
+319
+00:23:08,050 --> 00:23:13,610
+البويضات الـ ovary تكون محصلة المخزون فيه تكاد
+
+320
+00:23:13,610 --> 00:23:18,270
+تكون منعدمة فما تصير عنده menstrual cycle بالإضافة
+
+321
+00:23:18,270 --> 00:23:21,790
+إلى إن الهرمونات تصير في عنده fluctuation في مستوى
+
+322
+00:23:21,790 --> 00:23:25,950
+الهرمونات أو في كفاءة الـ Receptor إذا الـ Atresia
+
+323
+00:23:25,950 --> 00:23:31,590
+بتكون واضحة قبل عملية البلوأزداد بشكل ملحوظ جدا
+
+324
+00:23:31,590 --> 00:23:35,710
+بعد البلوك في مرحلة الأضغط تكون هي المسيطرة على
+
+325
+00:23:35,710 --> 00:23:40,670
+حياة السيدة بعد ال post-menopausal stage فبتصير هي
+
+326
+00:23:40,670 --> 00:23:45,470
+اللي بتاخد أكبر حيز من الأحداث، lethargy انقسام
+
+327
+00:23:45,470 --> 00:23:49,950
+الميتوزي عند الذكور كمان أنا حكيت عند الاناث بتبقى
+
+328
+00:23:49,950 --> 00:23:54,010
+في الشهر التاني للشهر الخامس من عمر الجنين للأنثى
+
+329
+00:23:54,010 --> 00:23:58,610
+عند الذكور يختلف، فألاقي أن انقسام الميتوزي عند
+
+330
+00:23:58,610 --> 00:24:03,510
+الذكورببدأ بشكل مبكر جدا من مرحلة الـ Empyrionic
+
+331
+00:24:03,510 --> 00:24:08,210
+Testes ولكن بتوجه في الـ Second Trimester يعني
+
+332
+00:24:08,210 --> 00:24:11,950
+بداية ال Second Trimester بتوجه في بداية ال Second
+
+333
+00:24:11,950 --> 00:24:15,330
+Trimester لإنوا عارفين الحمل يقص تسعة شهور يقسم
+
+334
+00:24:15,330 --> 00:24:20,170
+First, Second, Third Trimester تلت شهور الأولى،
+
+335
+00:24:20,170 --> 00:24:23,730
+تلت شهور التانية، تلت شهور الأخيرة من واحد لدلده،
+
+336
+00:24:23,730 --> 00:24:28,330
+من أربع على ستة ومن سبعة تمانية تسعة لل Third
+
+337
+00:24:28,330 --> 00:24:34,170
+Trimesterأو بتسميه ال third أو ال trimester طبعا
+
+338
+00:24:34,170 --> 00:24:37,510
+ال third trimester في ال second trimester يعني
+
+339
+00:24:37,510 --> 00:24:41,110
+بمعنى آخر في نهاية الشهر التالت من الحمل إذا كان
+
+340
+00:24:41,110 --> 00:24:45,770
+الجنين ذكر بتوقف الانقسام الميتوزي و بظل انقسام
+
+341
+00:24:45,770 --> 00:24:54,050
+الميتوزي متوقف and does not resume until حتى ال
+
+342
+00:24:54,050 --> 00:24:57,970
+blueيعني بمعنى آخر إن الإنقسام الميتوزي بتوقف عند
+
+343
+00:24:57,970 --> 00:25:04,350
+الجنين الذكر من بداية الـ second trimester حتى سن
+
+344
+00:25:04,350 --> 00:25:07,190
+البلوك بمجرد ما يصل الذكر لسن البلوك بيبدأ
+
+345
+00:25:07,190 --> 00:25:11,410
+الإنقسام الميتوزي يشتغل ويستمر مرة أخرى in
+
+346
+00:25:11,410 --> 00:25:14,070
+contrast to female germ cell male germ cell
+
+347
+00:25:14,070 --> 00:25:16,410
+maintains the ability to divide throughout
+
+348
+00:25:16,410 --> 00:25:21,270
+postnatal life بمعنى آخر إن ال germ cell الخاصة
+
+349
+00:25:21,270 --> 00:25:27,120
+بالذكر تستمر في الإنقسامطيلة فترة حياته، طيلة فترة
+
+350
+00:25:27,120 --> 00:25:30,280
+حياته، عشان كده بلاجي ال male بعد الخمسين و بعد
+
+351
+00:25:30,280 --> 00:25:33,720
+الستين و بعد السبعين، فيه عندهم spermatocyte و
+
+352
+00:25:33,720 --> 00:25:36,660
+spermateid، فيه عندهم spermatozoa و فيه عندهم
+
+353
+00:25:36,660 --> 00:25:40,680
+sperm، هذه كلها مصطلحات لل sperm، بينما ال female
+
+354
+00:25:40,680 --> 00:25:44,060
+مابلاجي عندها oocyte بعد الخمسة و أربعين، نادر جدا
+
+355
+00:25:45,290 --> 00:25:48,030
+طبعا في منطقة في الـ testes endymal بنتسميها الـ
+
+356
+00:25:48,030 --> 00:25:52,670
+semi-nervostipule هي المنطقة المصنع المصنع اللي
+
+357
+00:25:52,670 --> 00:25:56,670
+بتتم فيها تصنيع ال sperm metocyte اللي بنتسميه
+
+358
+00:25:56,670 --> 00:26:00,890
+spermatogonia sperm metocyte أو ال sperm لما يكون
+
+359
+00:26:00,890 --> 00:26:05,190
+في منطقة ال seminal .. seminal .. semen .. nervous
+
+360
+00:26:05,190 --> 00:26:10,570
+tipule بسميه spermatogoniaفي بداية سن البلوغ الـ
+
+361
+00:26:10,570 --> 00:26:14,270
+spermatogonium بتمر بعدة مراحل من التغيرات من
+
+362
+00:26:14,270 --> 00:26:20,330
+القسم الميتوزي علشان تتحول من spermatogonium إلى
+
+363
+00:26:20,330 --> 00:26:25,690
+sperm .. إلى sperm وهذه العملية بتظل مستمرة طول
+
+364
+00:26:25,690 --> 00:26:32,290
+فترة حياة الذكر .. طول فترة حياة الذكر نجي للحدث
+
+365
+00:26:32,290 --> 00:26:36,130
+التالت اللي بيصير وهو عبارة عن reduction in the
+
+366
+00:26:36,130 --> 00:26:39,940
+chromosome numberطبعا عشان أقول reduction إذا لازم
+
+367
+00:26:39,940 --> 00:26:44,380
+يكون فيها انقسام منصف وانقسام المنصف هو عبارة عن
+
+368
+00:26:44,380 --> 00:26:50,120
+انقسام الميوزي وده انقسام ميوز عارفين ان خلية
+
+369
+00:26:50,120 --> 00:26:54,280
+بتكون فيها اتنين chromosome تعطيني خليتين كل واحدة
+
+370
+00:26:54,280 --> 00:26:57,580
+فيها واحد chromosome نسميها خلية فيها اتنين N
+
+371
+00:26:57,580 --> 00:27:01,440
+تعطيني two cell كل واحدة فيها one N عشان كده
+
+372
+00:27:01,440 --> 00:27:06,260
+بنسميه انقسام منصف او ميوزيطبعا ال biological
+
+373
+00:27:06,260 --> 00:27:10,080
+significance of meiosis should be or will be
+
+374
+00:27:10,080 --> 00:27:13,220
+summarized as the following عشان أصبح عندي انقسام
+
+375
+00:27:13,220 --> 00:27:17,300
+ميوزي لازم أن ألخصه في أكثر من نقطة النقطة الأولى
+
+376
+00:27:17,300 --> 00:27:20,760
+نقطة ال reduction وإيش بيصير في ال reduction أنه
+
+377
+00:27:20,760 --> 00:27:26,040
+في عندى خلية تحتوي على deploy 2N أو 2S المقصود
+
+378
+00:27:26,040 --> 00:27:30,120
+بالـ2N هي الـ2 كروموزوم الـS اختصارا لكروموزوم
+
+379
+00:27:30,120 --> 00:27:35,120
+هتنقسم لتعطي خليتك و الخلية فيها 1N اللي بنسميه
+
+380
+00:27:35,280 --> 00:27:38,760
+Heploid So that the kind number of chromosome can
+
+381
+00:27:38,760 --> 00:27:42,380
+be maintained from generation to generation بهذه
+
+382
+00:27:42,380 --> 00:27:47,000
+القالية قالية ال reduction التي تتبع انقسام
+
+383
+00:27:47,000 --> 00:27:52,280
+الميوزي بتم المحافظة على المادة الوراثية و
+
+384
+00:27:52,280 --> 00:27:55,720
+الكرموزومات لكي تنتقل من generation ل generation
+
+385
+00:27:55,720 --> 00:28:00,540
+لذلك هذه أول مرحلة من المراحل الميوزي يليها
+
+386
+00:28:00,540 --> 00:28:03,860
+independent أو حاجة نسميها
+
+387
+00:28:07,790 --> 00:28:11,630
+resortment أي بمعنى أخر إعادة التجميع إعادة
+
+388
+00:28:11,630 --> 00:28:15,090
+التجميع إيش بمعنى إعادة التجميع؟ إنه في عنده
+
+389
+00:28:15,090 --> 00:28:18,410
+جامطات من الذكر و هي المادة الوراثية اللي جاي من
+
+390
+00:28:18,410 --> 00:28:22,530
+ال sperm و جامطات من الأنثة و هي المادة الوراثية
+
+391
+00:28:22,530 --> 00:28:25,450
+اللي جاي من الأنثة كرموزومات ذكرية و كرموزومات
+
+392
+00:28:25,450 --> 00:28:30,270
+أنثوية لازم يجتمعوا مع بعض و يصير mix ما بينهم و
+
+393
+00:28:30,270 --> 00:28:34,890
+تبادل للمادة الوراثية هذا بنسميها التجميع الغير
+
+394
+00:28:34,890 --> 00:28:42,170
+معتمديعني ما بيتمد على شيء بيدفعه بيصير بشكل مستقل
+
+395
+00:28:42,170 --> 00:28:45,670
+independent بعد كده بيصير حاجة بيسميها
+
+396
+00:28:45,670 --> 00:28:50,010
+redistribution
+
+397
+00:28:50,010 --> 00:28:54,550
+يعني إعادة التوزيع سبحان الله في مناطق على
+
+398
+00:28:54,550 --> 00:28:57,690
+الكرومزومات ال male و الكرومزومات ال female
+
+399
+00:28:57,690 --> 00:29:03,110
+متشابهة فبصير تبديل المنطقة هذه بتروح كرومزوم
+
+400
+00:29:03,110 --> 00:29:06,080
+الأولىو المنطقة هي دي نفسها اللي موجودة على
+
+401
+00:29:06,080 --> 00:29:10,020
+كرومزوم الأنثى بتروح كرومزوم الذكر تحت مصطلح
+
+402
+00:29:10,020 --> 00:29:13,040
+redistribution redistribution for what?
+
+403
+00:29:13,400 --> 00:29:16,320
+redistribution for maternal and paternal genetic
+
+404
+00:29:16,320 --> 00:29:20,640
+information through this process called crossing
+
+405
+00:29:20,640 --> 00:29:25,280
+over اللي كنا ناس نسميها فيما سبق التصالب العبور
+
+406
+00:29:25,280 --> 00:29:29,460
+إيش التصالب العبور؟ ببساطة جدا أي كرومزوم في عنده
+
+407
+00:29:29,460 --> 00:29:33,380
+عبارة عن two sister chromatid two sister chromatid
+
+408
+00:29:33,860 --> 00:29:38,200
+لو الكرموزوم رقم واحد في الذكر بيجي في الكرموزوم
+
+409
+00:29:38,200 --> 00:29:42,140
+رقم واحد في الأنثى متقابلين ال sister chromatid
+
+410
+00:29:42,140 --> 00:29:46,000
+الداخلي في نقاط ومناطق معينة متشابهة على كيلو
+
+411
+00:29:46,000 --> 00:29:51,600
+الكرموزوم بتم تبادلهم تحت مصطلح redistribution أو
+
+412
+00:29:51,600 --> 00:29:56,620
+crossing over on a major compound of the first
+
+413
+00:29:56,620 --> 00:30:00,660
+meiotic division is genetic recombination takes a
+
+414
+00:30:00,660 --> 00:30:06,330
+changeمن المادة
+
+415
+00:30:06,330 --> 00:30:10,230
+الوراثية أو مناطق معينة موجودة على الكرموزوم بتتم
+
+416
+00:30:10,230 --> 00:30:16,170
+تبادلهم في السيستر كرماتية الداخل One form of
+
+417
+00:30:16,170 --> 00:30:20,170
+recombination which typically occur early in the
+
+418
+00:30:20,170 --> 00:30:22,850
+prophase involve short segments and occur through
+
+419
+00:30:22,850 --> 00:30:27,660
+the mechanism similar to the anaerobicأحد صفات الـ
+
+420
+00:30:27,660 --> 00:30:32,060
+Redistribution أو الـ Recombination إن قطعة معينة
+
+421
+00:30:32,060 --> 00:30:35,800
+موجودة على الـ Male أو الـ Female كروموزوم نفس
+
+422
+00:30:35,800 --> 00:30:38,220
+الكروموزوم طبعاً لما نقول كروموزوم 1 عند الـ Male
+
+423
+00:30:38,220 --> 00:30:40,620
+و الـ Female أو كروموزوم 8 عند الـ Male و الـ
+
+424
+00:30:40,620 --> 00:30:45,520
+Female تصير تبادل لهذه القطعة بمصطلح يشبه إلى حد
+
+425
+00:30:45,520 --> 00:30:49,820
+ما مصطلح التصاريف العجول وتشبه إلى حد ما حاجة
+
+426
+00:30:49,820 --> 00:30:53,500
+بنسميها الـ DNA repair شو يعني الـ DNA repair؟
+
+427
+00:30:53,500 --> 00:30:58,190
+يعني تصليح الأخطاقهل في أخطاء بتصير؟ هو يعتبر
+
+428
+00:30:58,190 --> 00:31:02,910
+انتقال القطعة من كروموزوم الأب إلى كروموزوم الأم
+
+429
+00:31:02,910 --> 00:31:06,350
+وانتقال نفس القطعة من كروموزوم الأم إلى كروموزوم
+
+430
+00:31:06,350 --> 00:31:09,810
+الأب هي عبارة عن عملية قطع وعادة لصق فهي عبارة عن
+
+431
+00:31:09,810 --> 00:31:13,550
+repair وبعض الأحيان بيعمل check up عشان يتأكد إن
+
+432
+00:31:13,550 --> 00:31:17,270
+نفس القطعة نقلت أو لا طبعا هذه العملية عملية
+
+433
+00:31:17,270 --> 00:31:21,170
+crossing over أو redistribution بتصير في stage
+
+434
+00:31:21,170 --> 00:31:27,450
+معين بنسمي Pactin stage أيضاهذه العملية لا تحدث
+
+435
+00:31:27,450 --> 00:31:31,810
+على الـ autosome للكرموزوم و هي الكرموزوم الجسدية
+
+436
+00:31:31,810 --> 00:31:36,330
+لها تحدث على 6 كرموزوم زي ال X و ال Y معقول هل في
+
+437
+00:31:36,330 --> 00:31:39,750
+مناطق على ال X تشبه المناطق الموجودة على ال Y؟
+
+438
+00:31:39,750 --> 00:31:43,550
+صحيح، في مناطق على ال X تتشبه مع المناطق الموجودة
+
+439
+00:31:43,550 --> 00:31:48,450
+على ال Y و هي عبارة عن مناطق حيوية ولكن لا تدخل في
+
+440
+00:31:48,450 --> 00:31:51,810
+تحديد جلس المولودفي هذه المناطق بيصير لها crossing
+
+441
+00:31:51,810 --> 00:31:56,790
+over أو redistribution أو استبدال crossing over is
+
+442
+00:31:56,790 --> 00:32:01,550
+not okay و randomly طبعا هذه عملية التصالب والعبور
+
+443
+00:32:01,550 --> 00:32:06,830
+أو عملية تبادل القطع ما بتصير بشكل عشوائي لأ بتصير
+
+444
+00:32:06,830 --> 00:32:11,970
+تحت control بشكل عالي جدا بطريقة مرتبة جدا في
+
+445
+00:32:11,970 --> 00:32:15,390
+مناطق معينة جدا هذه المناطق في الغالب بيسموها hot
+
+446
+00:32:15,390 --> 00:32:19,010
+spot على الكروبوزونما في حاجة بتصير داخل جسم
+
+447
+00:32:19,010 --> 00:32:24,870
+الإنسان بشكل عشوائي أو بشكل تلقائي في الوضع
+
+448
+00:32:24,870 --> 00:32:32,110
+الطبيعي طبعا هذه صورة بتوضحلي الـ Pro phase وهو
+
+449
+00:32:32,110 --> 00:32:37,390
+عبارة عن انقسام أو طور من أطوار انقسام الميوزي لو
+
+450
+00:32:37,390 --> 00:32:41,290
+أنا جيت للطور التالت الـ Actin Stage اللي بيصير
+
+451
+00:32:41,290 --> 00:32:45,270
+فيه التصالب و العبور وعبارة عن أحد الأطوار اللي
+
+452
+00:32:45,270 --> 00:32:48,860
+بيصير فيها ال crossing overيأتي مباشرة بعد تكوين
+
+453
+00:32:48,860 --> 00:32:53,680
+الزيجوت طب شو هي الزيجوت؟ الزيجوت هي اندماج النواة
+
+454
+00:32:53,680 --> 00:32:57,900
+الخاصة بالـ Spear مع النواة الخاصة بالـ Oocyte
+
+455
+00:32:57,900 --> 00:33:03,620
+لتكوين نواة واحدة بنسميها زيجوت أو الزيجوت هي
+
+456
+00:33:03,620 --> 00:33:09,160
+عبارة عن خلية تحتوي على نواة واحدة هذه النواة تنتج
+
+457
+00:33:09,160 --> 00:33:12,660
+من اندماج المادة الوراثية الخاصة بالأرض مع المادة
+
+458
+00:33:12,660 --> 00:33:17,760
+الوراثية الخاصة بالأرض فبسميها زيجوتأسميها زي ما
+
+459
+00:33:17,760 --> 00:33:23,120
+ترونها طبعاً موقعها يعتمد على تنظيم البروتين التي
+
+460
+00:33:23,120 --> 00:33:28,600
+أُرغنزت كروموزوم في ميوسيس فهذه العملية و المناطق
+
+461
+00:33:28,600 --> 00:33:32,720
+اللي بيصير فيها الـ crossing over تعتمد على درجة
+
+462
+00:33:32,720 --> 00:33:38,080
+عالية من الكرتير و التأكد و تكتب بروتينات معينة
+
+463
+00:33:38,080 --> 00:33:41,600
+مسؤولة عن عملية العملية من أشهر هذه العملية التي
+
+464
+00:33:41,600 --> 00:33:46,880
+تعمل علىإتمام عملية الـ crossing over بروتين نسميه
+
+465
+00:33:46,880 --> 00:33:53,120
+cohesin protein من أشهر البروتينات التي تساعد على
+
+466
+00:33:53,120 --> 00:33:58,040
+إتمام و بدء الـ crossing over حيث تساعد على ربط
+
+467
+00:33:58,040 --> 00:34:01,240
+الـ two sister chromatid مع بعض و مع البعض two
+
+468
+00:34:01,240 --> 00:34:04,840
+sister chromatid عفوا المقصود في hold sister
+
+469
+00:34:04,840 --> 00:34:07,000
+chromatid together during division لما أقول two
+
+470
+00:34:07,000 --> 00:34:09,860
+sister chromatid يعني كل كرمزوم في two sister
+
+471
+00:34:09,860 --> 00:34:12,910
+chromatid لما أجيب كرمزوم واحد من الأبمع كرموزوم
+
+472
+00:34:12,910 --> 00:34:18,710
+واحد من الـ O لازم يصطفوا أمام بعض بشكل متوازي
+
+473
+00:34:18,710 --> 00:34:22,010
+وبعدين ييجي الـ sister الكرمتيد الداخلي الخاص
+
+474
+00:34:22,010 --> 00:34:24,730
+بالأب مع ال sister الكرمتيد الداخلي الخاص بالأم
+
+475
+00:34:24,730 --> 00:34:28,330
+بيصير فيهم crossing over طبعا البروتين اللي بيقوم
+
+476
+00:34:28,330 --> 00:34:33,550
+بعملية الاصطفاف البروتين بنسميه cohesin protein في
+
+477
+00:34:33,550 --> 00:34:36,710
+عملية تانية بنسميها hypermethylation هذه الـ
+
+478
+00:34:36,710 --> 00:34:39,990
+hypermethylation بتصير على ال DNA وبتصير على ال
+
+479
+00:34:39,990 --> 00:34:43,070
+بيستون والبيستون هو عبارة عن البروتينولكن الـ
+
+480
+00:34:43,070 --> 00:34:45,070
+hypermethylation بتصير على الـ stone و لما أقول
+
+481
+00:34:45,070 --> 00:34:48,010
+hypermethylation يعني زيادة في عملية الـ
+
+482
+00:34:48,010 --> 00:34:50,790
+methylation شو هي الـ methylation؟ الـ methylation
+
+483
+00:34:50,790 --> 00:34:54,810
+هي عبارة عن عملية يتم فيها إضافة مجموعة methyl
+
+484
+00:34:54,810 --> 00:34:59,910
+group CH3 على الـ cytosine طب على كل الـ cytosine؟
+
+485
+00:34:59,910 --> 00:35:03,550
+لأ على الـ cytosine التي تتبعها جوانين فقط لغاية
+
+486
+00:35:03,550 --> 00:35:07,250
+طبعا لما نصير hypermethylation على الـ stoneIn
+
+487
+00:35:07,250 --> 00:35:10,650
+chromatin بعمل indication specific site where DNA
+
+488
+00:35:10,650 --> 00:35:14,650
+strand should be break and are later repaired
+
+489
+00:35:14,650 --> 00:35:16,910
+after crossing over لما يصير في هندي
+
+490
+00:35:16,910 --> 00:35:20,070
+hypermethylation بيصير relaxation للstone
+
+491
+00:35:20,070 --> 00:35:24,150
+relaxation للstone بيسمح لبعض الإنزيمات تدخل و
+
+492
+00:35:24,150 --> 00:35:27,430
+تقطع مناطق معينة هذا المناطق لازم يصير فيها
+
+493
+00:35:27,430 --> 00:35:31,630
+crossing over بعد كده بيصير لها repairing في
+
+494
+00:35:31,630 --> 00:35:35,150
+بروتين آخر بيساعد في عملية ال crossing over بنسميه
+
+495
+00:35:35,290 --> 00:35:39,350
+Condensin Protein أو Condensed Protein هذا مهم
+
+496
+00:35:39,350 --> 00:35:44,850
+جدًا للبروتين لأنه يعمل عملية مهمة جدًا في عمل
+
+497
+00:35:44,850 --> 00:35:49,450
+Condensation للكرومزومة ناخد ملاحظة مهمة جدًا أن
+
+498
+00:35:49,450 --> 00:35:53,270
+الكرومزوم في الأصل المادة الوراثية الموجودة بداخله
+
+499
+00:35:53,270 --> 00:35:57,190
+و هي الكروماتين لازم تكون Closed عشان تكون Closed
+
+500
+00:35:57,190 --> 00:36:01,170
+لازم تصير Condensed لأنها لما تصير Condensed هذا
+
+501
+00:36:01,170 --> 00:36:06,000
+يمنعها من أي ضرر ممكن يواجههاأي أنزين ممكن يشتغل
+
+502
+00:36:06,000 --> 00:36:09,820
+عليها طب علشان يصير ال crossing over لازم يصير في
+
+503
+00:36:09,820 --> 00:36:12,760
+عندى decondensation لهذا الكروماتين، يعني
+
+504
+00:36:12,760 --> 00:36:16,180
+relaxation واللي بيعمل ال relaxation هي عبارة عن
+
+505
+00:36:16,180 --> 00:36:19,380
+الـ hypermethylation لذلك، البروتين الـ Condensed
+
+506
+00:36:19,380 --> 00:36:22,800
+يلعب رولة مهمة جدًا في الcrossing over من
+
+507
+00:36:22,800 --> 00:36:26,740
+الكرومزوم اللي محتاجه لكلا الميوتك والميتوتك
+
+508
+00:36:26,740 --> 00:36:32,040
+للإكمال بدون البروتين الـ Condensed ما فيه ميتوتك
+
+509
+00:36:32,040 --> 00:36:36,060
+division وما فيه ميوتك divisionالـ Second Meiotic
+
+510
+00:36:36,060 --> 00:36:43,160
+Division أو انقسام الميوز التاني هو انقسام المنصف
+
+511
+00:36:43,160 --> 00:36:46,980
+وفي الغالب .. في الغالب انقسام الميوز التاني هو
+
+512
+00:36:46,980 --> 00:36:53,040
+عبارة عن انقسام ميتوزي ولكن لا يُسبق بطور تمهيدي
+
+513
+00:36:53,040 --> 00:36:58,470
+يؤدي إلى زيادة عدد الكرموزوماتلأن أي انقسام مثل
+
+514
+00:36:58,470 --> 00:37:04,130
+انقسام الميتوزي يمر بالـ Prophase الـ Metaphase
+
+515
+00:37:04,130 --> 00:37:08,770
+الـ Anaphase الـ Telophase هو يسبقه انقسام تمهيدي
+
+516
+00:37:08,770 --> 00:37:13,790
+انقسام تمهيدي أو عفوا طور تمهيدي بتمثيل تضاعف
+
+517
+00:37:13,790 --> 00:37:18,010
+المادة الوراثية تضاعف المادة الوراثية فبالتالي
+
+518
+00:37:18,010 --> 00:37:22,950
+انقسام الميوزي الثاني هو عبارة عن انقسام ميتوزي
+
+519
+00:37:22,950 --> 00:37:28,480
+ولكن لا يسبقه طورا تمهيديالتضعف المادة الوراثية
+
+520
+00:37:28,480 --> 00:37:32,060
+عشان كده بتدخل اتنين and تطلع two cell كل واحدة
+
+521
+00:37:32,060 --> 00:37:38,500
+منهم one and فسمّاه انقسام منصف صورة بتوضح لي
+
+522
+00:37:38,500 --> 00:37:41,420
+الكلام اللي أنا حكيته على البوايضة الصورة ممكن
+
+523
+00:37:41,420 --> 00:37:45,220
+تلاقيها معقدة ولكن خلّينا ناخدها step by step تحت
+
+524
+00:37:45,220 --> 00:37:49,420
+عنوان the major event of human oogenesis and
+
+525
+00:37:49,420 --> 00:37:53,900
+follicular development هي عمر السيدة عمر السيدة
+
+526
+00:37:53,900 --> 00:38:00,380
+يقسم كتاليفترة أو العمر الجنيني ما قبل الولادة حتى
+
+527
+00:38:00,380 --> 00:38:05,300
+الولادة نبدأ من اليسار بعد الولادة و بعد الولودة
+
+528
+00:38:05,300 --> 00:38:09,400
+هذه ثلاث أحداث ايش بيصير فيها؟ طبعا لو انا طلعت
+
+529
+00:38:09,400 --> 00:38:14,840
+على الصورة صورة عبارة عن بويضة سموها بهذا الشكل في
+
+530
+00:38:14,840 --> 00:38:18,320
+ما قبل الميلاد او عفوا الطور الجنيني اللي بتسميه
+
+531
+00:38:18,320 --> 00:38:23,040
+fetal period no follicles مافي follicles التكونت
+
+532
+00:38:24,060 --> 00:38:29,840
+الـ Follicle هي عبارة عن بويضات موجودة داخل خلية
+
+533
+00:38:29,840 --> 00:38:33,340
+محفظة، بسميها لكل الـ Structure Follicle وهذه ما
+
+534
+00:38:33,340 --> 00:38:37,080
+بتكون إلا في وجود الرحم وعفوا، وجود المبيض، اللذي
+
+535
+00:38:37,080 --> 00:38:39,500
+يعتبر جزء من الجهاز التناثوري الـ Reproductive
+
+536
+00:38:39,500 --> 00:38:43,440
+System طبعا الـ Fetal Period لسه ما فيه Over اتكون
+
+537
+00:38:43,440 --> 00:38:46,260
+لأن الـ Primordial Germ Cell لسه خارج منطقة
+
+538
+00:38:46,260 --> 00:38:52,640
+الكونية فما فيه No Follicle جبل الميلاد تكون الـ
+
+539
+00:38:52,640 --> 00:38:55,500
+Follicle بدأت تتكونو ال primordial germ cell اللي
+
+540
+00:38:55,500 --> 00:39:00,560
+اتكونت بعد الميلاد بسمي ال primordial germ cell أو
+
+541
+00:39:00,560 --> 00:39:03,900
+ال primordial follicle إلى primar follicle بعد
+
+542
+00:39:03,900 --> 00:39:07,060
+البلو بسمي ال primar follicle secondary follicle
+
+543
+00:39:07,060 --> 00:39:11,580
+بعدين بسميها tertiary بعدين بصير ovulated oocyte
+
+544
+00:39:11,580 --> 00:39:15,120
+بعدين ال fertilization oocyte انصار fertilization
+
+545
+00:39:15,120 --> 00:39:19,740
+طب إيش الأحداث اللي بتصير؟ في ناس بيسميها أو علماء
+
+546
+00:39:19,740 --> 00:39:24,080
+بيسموها أو مدارس بيسموها تسمية أخرىفي منطقة الـ
+
+547
+00:39:24,080 --> 00:39:28,160
+Fetal Primordial بيسموها Ogonium حكينا إيش هي الـ
+
+548
+00:39:28,160 --> 00:39:32,240
+Ogonium هي عبارة عن Primordial جنب سلخ خضعت
+
+549
+00:39:32,240 --> 00:39:38,280
+لانقسام ميتوزي متكرر وصلت لسبعة ملوى بعد كده جاب
+
+550
+00:39:38,280 --> 00:39:44,080
+للميلاد حتى الميلاد بيسميها Primary Oocyte طبعا
+
+551
+00:39:44,080 --> 00:39:46,620
+الأحداث اللي بتصير ما بين ال Ogonium و ال Primary
+
+552
+00:39:46,620 --> 00:39:51,800
+Oocyte هي انقسامات ميتوزية علشان كده السيدة أو
+
+553
+00:39:51,800 --> 00:39:58,040
+الأنثىعندما تولد يكون المبيض يحتوي على خلايا تقدر
+
+554
+00:39:58,040 --> 00:40:02,040
+بعدد كبير ملايين الخلايا هنعرف قداش العدد بالضبط
+
+555
+00:40:02,040 --> 00:40:09,060
+تسمى Primary Oocyte طالما هو عبارة عن جنين بسميها
+
+556
+00:40:09,060 --> 00:40:14,500
+Ogonium أول ما يصير مولود بابي حي بسميها Primary
+
+557
+00:40:14,500 --> 00:40:19,380
+Oocyte طبعا ال Primary Oocyte بتخضع لانقسام ميوزي
+
+558
+00:40:20,300 --> 00:40:24,400
+وبتظلها حتى بعد الميلاد على شكل الـ primary oocyte
+
+559
+00:40:24,400 --> 00:40:29,360
+بعد الميلاد بتصير عملية arrested استقرار وإيقاف
+
+560
+00:40:29,360 --> 00:40:34,660
+للانقسام الميتوزي في طور معين وهو عبارة عن الـ
+
+561
+00:40:34,660 --> 00:40:41,180
+diprotin stage الخاص بالانقسام الميتوزي إذا وصلت
+
+562
+00:40:41,180 --> 00:40:46,400
+الأنثى إلى سن البلوغ 8، 9، 10، 11، 12، 13 whatever
+
+563
+00:40:47,310 --> 00:40:55,390
+الـ Primary Oocyte تبقى Primary Oocyte وتستكمل
+
+564
+00:40:55,390 --> 00:40:59,050
+انقسام الميوزي الأول لأنه صار في عندي إيقاف
+
+565
+00:40:59,050 --> 00:41:03,490
+لانقسام الميوزي الأول في مرحلة بنتسميها الـ
+
+566
+00:41:03,490 --> 00:41:08,470
+diprotin stage تستكمل انقسام الميوزي الأول بمجرد
+
+567
+00:41:08,470 --> 00:41:13,650
+استكمالها انقسام الميوزي الأول حطيقيني خلية تسمى
+
+568
+00:41:13,650 --> 00:41:20,490
+secondary oocyteوخلية تسمى polar body أيش الفرق
+
+569
+00:41:20,490 --> 00:41:23,010
+بين ال secondary oocyte و ال polar body تعالى
+
+570
+00:41:23,010 --> 00:41:26,950
+ناخدها من الأول ال Ogonia بيقول فيها عندها خلية
+
+571
+00:41:26,950 --> 00:41:32,270
+تحتوى على two chromosome two C نين S two S يعني
+
+572
+00:41:32,270 --> 00:41:36,370
+two chromosomeالـ Primary Oocyte لأنها اتخضعت
+
+573
+00:41:36,370 --> 00:41:40,210
+لانقسام ميتوزي يحدث فيه تضاعف لعدد الكرموزومات
+
+574
+00:41:40,210 --> 00:41:45,070
+وتضاعف الخلايا فاعطاني Primary Oocyte تحتوي على 4S
+
+575
+00:41:45,070 --> 00:41:50,450
+يعني أربع كرموزومات تستمر على شكل Primary Oocyte
+
+576
+00:41:50,450 --> 00:41:54,030
+Primary Oocyte ومجرد ال Primary Oocyte بعد ما
+
+577
+00:41:54,030 --> 00:41:57,370
+اتوجفت في الـ Diploting Stage الخاص بالانقسام
+
+578
+00:41:57,370 --> 00:42:01,610
+الميتوزي الأول معناه هي ما كمل انقسام الميتوزي
+
+579
+00:42:01,610 --> 00:42:06,380
+الأولبمجرد ما تكمل انقسام الـ mitosis الأول و هو
+
+580
+00:42:06,380 --> 00:42:11,720
+الذي يحدث بمجرد وصول السيدة إلى سن الرشد الخلايا
+
+581
+00:42:11,720 --> 00:42:16,800
+اللي بتكون 4C تتحول إلى خليتين، كل خلية فيها اتنين
+
+582
+00:42:16,800 --> 00:42:21,080
+أس الاتنين أس التانية وين راحت؟ تحولت إلى polar
+
+583
+00:42:21,080 --> 00:42:24,960
+body يعني في عندي خلية هي عبارة عن ال primary
+
+584
+00:42:24,960 --> 00:42:28,490
+oocyteكملت الإنقسام اللي تحتوي على الاربعة
+
+585
+00:42:28,490 --> 00:42:33,750
+كرموزومات قملت الإنقسام الميتوزي الأول فعطتني خلية
+
+586
+00:42:33,750 --> 00:42:38,290
+فيها 2S وخلية فيها 2S الخلية الأولى فيها 2S سميتها
+
+587
+00:42:38,290 --> 00:42:42,290
+secondary oocyte و الخلية التانية فيها 2S سميتها
+
+588
+00:42:42,290 --> 00:42:47,110
+polar body why؟ ليش أنا سميتها polar body؟ لأنها
+
+589
+00:42:47,110 --> 00:42:51,030
+عبارة عن خليةتحتوي على 2 كرومزومات، 2 من
+
+590
+00:42:51,030 --> 00:42:55,290
+الكرومزومات ولكن كمية الهضيات وكمية الـ cytoplasm
+
+591
+00:42:55,290 --> 00:43:00,110
+اللي موجودة فيها لا تكفي أو لا تكفيها لكي ترتقي
+
+592
+00:43:00,110 --> 00:43:04,350
+إلى أن تصبح بويضة نادجة فبسميها polar body هل تخضع
+
+593
+00:43:04,350 --> 00:43:06,890
+لل fertilization؟ ليس لها علاقة بال fertilization
+
+594
+00:43:06,890 --> 00:43:11,610
+هل تنقسم؟ بعض المدارس بيقولك تنقسم ولكن لا ترتقي
+
+595
+00:43:11,610 --> 00:43:15,450
+إلى درجة secondary oocyte لكي تكمل عملية النقسام
+
+596
+00:43:15,450 --> 00:43:20,650
+ونحصل على بويضة نادجةالـ secondary oocyte بعد
+
+597
+00:43:20,650 --> 00:43:25,470
+البلوغ بيصير اللي هي عملية ovulation على شكل
+
+598
+00:43:25,470 --> 00:43:28,890
+secondary oocyte طب السؤال ال secondary oocyte
+
+599
+00:43:28,890 --> 00:43:32,530
+فيها اتنين كروموزوم و لو لقحت هتاخد كمان كروموزوم
+
+600
+00:43:32,530 --> 00:43:35,690
+من الذكر ال spirit هيصير فيه عند تلاتة كروموزوم
+
+601
+00:43:35,690 --> 00:43:39,950
+يعني عدد الكروموزومات لازم تكون في الطبيعة اتنين
+
+602
+00:43:39,950 --> 00:43:43,150
+فإذا حصلت على تلاتة فلا تصلح لعملية ال
+
+603
+00:43:43,150 --> 00:43:48,580
+fertilization البويضة إذا صارها ovulationعلى شكل
+
+604
+00:43:48,580 --> 00:43:56,720
+secondary oocyte وتحتوى على 2 كروموزوم تكون صالحة
+
+605
+00:43:56,720 --> 00:44:01,400
+لل fertilization ولا تستكمل عملية الانقسام الميوزي
+
+606
+00:44:01,400 --> 00:44:05,800
+التالي إلا بعد عملية ال fertilization بمجرد ما
+
+607
+00:44:05,800 --> 00:44:09,660
+يصير fertilization وهذا اللي بنسميها secondary
+
+608
+00:44:09,660 --> 00:44:13,660
+oocyte plus polar body بتصيرها arrested في مرحلة
+
+609
+00:44:13,660 --> 00:44:17,760
+الmetaphase 2 إيه شعر مرحلة الmetaphase 2؟يعني الـ
+
+610
+00:44:17,760 --> 00:44:21,200
+metaphase الخاص للانقسام الميوزي التاني فهل في
+
+611
+00:44:21,200 --> 00:44:24,260
+انقسام ميوزي تاني؟ أكيد لأن احنا حكينا انقسام
+
+612
+00:44:24,260 --> 00:44:27,340
+الميوزي هو عبارة عن ميوزي أول وميوزي تاني الميوزي
+
+613
+00:44:27,340 --> 00:44:30,440
+التاني يشبه انقسام الميتوزي ولكن لا يسبق وتضاعف
+
+614
+00:44:30,440 --> 00:44:33,520
+المادة الوراق فيها بمجرد ما يصير fertilization
+
+615
+00:44:33,520 --> 00:44:38,180
+ودخول ال sperm ال sperm بعمل activation للبويضة
+
+616
+00:44:38,180 --> 00:44:43,120
+اللي في شكل secondary oocyte علشان تكمل انقسام
+
+617
+00:44:43,120 --> 00:44:47,080
+الميوزي تكمل انقسام الميوزي كيف؟هتفصل الـ two
+
+618
+00:44:47,080 --> 00:44:51,660
+chromosome واحد هيطلع بخلية تسمى secondary polar
+
+619
+00:44:51,660 --> 00:44:56,520
+body والتاني هيبقى داخل ال oocyte عشان يندمج مع ال
+
+620
+00:44:56,520 --> 00:44:59,980
+chromosome اللي جاي من ال sperm ويحصل لي على خلية
+
+621
+00:44:59,980 --> 00:45:05,700
+تحتوي على two chromosome بسميها fertilized oocyte
+
+622
+00:45:05,700 --> 00:45:11,620
+يعني المحصلة النهائية هي عبارة عن mature oocyte
+
+623
+00:45:11,620 --> 00:45:18,510
+تحتوي plus one polar body أوfertilized oocyte plus
+
+624
+00:45:18,510 --> 00:45:24,050
+two polar body خلّيني أشوف الفيديو اللي بتكلم عن
+
+625
+00:45:24,050 --> 00:45:29,370
+هذه العملية طبعا
+
+626
+00:45:29,370 --> 00:45:33,650
+هذا الفيديو بتكلم كيف بتصير عملية ال fertilization
+
+627
+00:45:33,650 --> 00:45:41,150
+وعملية ال oogenesis طبعا هذا عندي هذه منطقة ال
+
+628
+00:45:41,150 --> 00:45:43,830
+cervical هذه منطقة الرحم هذه منطقة الفلوبيا
+
+629
+00:45:43,830 --> 00:45:48,420
+الكيوبا هذه منطقة ال ovaryفي منطقة الـ ovary في
+
+630
+00:45:48,420 --> 00:45:57,020
+عند الـ fully kill بتكون مصفوفة على طول ال ovary
+
+631
+00:45:57,020 --> 00:46:00,340
+طبعا هذه المراحل اللي بيمر فيها من اليمين لليسار
+
+632
+00:46:00,340 --> 00:46:05,420
+بتكون primordial
+
+633
+00:46:05,420 --> 00:46:11,400
+germ cell وخلافه او immature oocyte او first
+
+634
+00:46:11,400 --> 00:46:15,940
+oocyte او primary oocyte مش المسمى ولكن اكتر
+
+635
+00:46:16,240 --> 00:46:20,200
+المسميات انتشارا هي ال primary oocyte او ال
+
+636
+00:46:20,200 --> 00:46:24,060
+ogonium بعدين تديني primary لان حكينا ogonium
+
+637
+00:46:24,060 --> 00:46:32,380
+primary secondary خلينا نشوف ايش العملية تصير فيها
+
+638
+00:46:32,380 --> 00:46:39,660
+هذا
+
+639
+00:46:39,660 --> 00:46:45,780
+بيعمل zoom على البوادة هي ال ogonium عمل zoom لها
+
+640
+00:46:46,680 --> 00:46:52,140
+البويضة بدأت تتطور دخلت الانقسام الميتوزي علشان
+
+641
+00:46:52,140 --> 00:47:00,060
+تتضاعف تضاعفت البويضة اعطتلي تنتين مثلا او جونيام
+
+642
+00:47:00,060 --> 00:47:05,400
+هتدخل انقسام نمت هتدخل انقسام الميوزي الأول فيه
+
+643
+00:47:05,400 --> 00:47:10,840
+عنده two chromosome وعشانها بويضة لازم تاخد
+
+644
+00:47:10,840 --> 00:47:13,680
+كرموزوم من الأم و كرموزوم من الأب لذا هذا ال two
+
+645
+00:47:13,680 --> 00:47:17,040
+chromosome لازم تفصلنحصل على وان كرموزوم والتاني
+
+646
+00:47:17,040 --> 00:47:21,980
+جيميل الأب طيب هتدخل انقسام ميوزي أول ومجرد ايه
+
+647
+00:47:21,980 --> 00:47:26,900
+primary oocyte primary oocyte دخلت انقسام ميوزي
+
+648
+00:47:26,900 --> 00:47:31,900
+أول هيتخلص من هذا الكرموزوم على شكل polar body
+
+649
+00:47:31,900 --> 00:47:37,580
+وعندي هذا الكرموزوم طبعا خد بالك كرموزوم هو عبارة
+
+650
+00:47:37,580 --> 00:47:41,140
+عن two sister chromatid فلازم تخلص من one sister
+
+651
+00:47:41,140 --> 00:47:45,070
+chromatid علشان ناخد التاني من الأبفبالتالي بحصل
+
+652
+00:47:45,070 --> 00:47:49,450
+على زوج من الكروموزون خلص منه او chromated
+
+653
+00:47:49,450 --> 00:47:52,590
+whatever المسمى مش عندهم كتير عن المسمى حاليا لان
+
+654
+00:47:52,590 --> 00:47:56,670
+هموضحها قدام بالتحصيل ان شاء الله هداني polar body
+
+655
+00:47:56,670 --> 00:48:02,870
+و secondary oocyte دخلت في انقسام الميوزي التاني
+
+656
+00:48:02,870 --> 00:48:07,410
+كملته طبعا هداني secondary polar body بس علشان
+
+657
+00:48:07,410 --> 00:48:12,650
+يكون الموضوع واضح جدا ان انقسام الميتوزي الثاني لا
+
+658
+00:48:13,050 --> 00:48:17,730
+يحدث و لا يتم إلا بمجرد حدوث ال fertilization
+
+659
+00:48:17,730 --> 00:48:22,030
+طالما البوايبة ماصرلش fertilization تبقى secondary
+
+660
+00:48:22,030 --> 00:48:27,410
+oocyte بدون second polar body لكن هذا animation ما
+
+661
+00:48:27,410 --> 00:48:33,110
+بقدر أوضحها فيها في ال animation هذا بالفعلطبعا
+
+662
+00:48:33,110 --> 00:48:36,630
+هنا بيقول الفولار بادي قد ينقسم صحيح قد ينقسم ولكن
+
+663
+00:48:36,630 --> 00:48:39,630
+لا يرتقي الى بوادة تلقح عشان كده بيصيرله
+
+664
+00:48:39,630 --> 00:48:44,110
+degradation عشان كده بيصيرله degradation فيما بعد
+
+665
+00:48:44,110 --> 00:48:48,770
+هذه
+
+666
+00:48:48,770 --> 00:48:53,270
+الفولار بادي بيصيرها عملية تدمير و removing و
+
+667
+00:48:53,270 --> 00:48:57,890
+بعدين بيصيرها the ghost انا سايرالايسز داخل الخلية
+
+668
+00:48:57,890 --> 00:49:03,990
+حصلت على employ egg طبعاجاهزة للتلقيح بس ده مش
+
+669
+00:49:03,990 --> 00:49:07,710
+دقيق ال animation كتير هنشوف animation تاني أكثر
+
+670
+00:49:07,710 --> 00:49:12,170
+درجة ان شاء الله هذا بالنسبة إلى تصنيع ال oocyte
+
+671
+00:49:12,170 --> 00:49:15,910
+ال primary وال secondary ال first polar body وال
+
+672
+00:49:15,910 --> 00:49:20,210
+second polar body كيف يتم عملية التنصيب هنكتفي
+
+673
+00:49:20,210 --> 00:49:24,610
+بهذا القدر في هذه المحاضرة على أن نستكمل في
+
+674
+00:49:24,610 --> 00:49:28,870
+المحاضرة القادمة ان شاء الله توم توم في حفظ الله
+
+675
+00:49:28,870 --> 00:49:29,910
+وارعة
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/Z4YwVN8UPs8_raw.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/Z4YwVN8UPs8_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..e4ceb19183084f58933b722165b705e63887dacd
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/Z4YwVN8UPs8_raw.srt
@@ -0,0 +1,2700 @@
+1
+00:00:01,530 --> 00:00:05,430
+بسم الله الرحمن الرحيم الصلاة والسلام على أشرف
+
+2
+00:00:05,430 --> 00:00:10,270
+المرسلين سيدنا محمد الصادق الأمين أما بعد بداية
+
+3
+00:00:10,270 --> 00:00:14,090
+أراحب بكم جميعا جديد وأرجو من الله الكريم أن
+
+4
+00:00:14,090 --> 00:00:18,960
+تكونوا جميعا بخير و بصحة جيدةفي المحاضرة السابقة
+
+5
+00:00:18,960 --> 00:00:23,680
+تطرحنا إلى عدة نقاط أهمها الـ infertility problem
+
+6
+00:00:23,680 --> 00:00:29,040
+تعريف ال infertility كيف تصنف ال infertility هل
+
+7
+00:00:29,040 --> 00:00:34,060
+تعتبر ال infertility أو التأثر في الإنجاب مشكلة
+
+8
+00:00:34,060 --> 00:00:39,680
+يعاني منها جميع الناس أم فيها معينة تحدثنا عن
+
+9
+00:00:39,680 --> 00:00:43,320
+أسباب ال infertility عند ال male و عند ال female
+
+10
+00:00:43,320 --> 00:00:48,490
+تحدثنا عن العوامل التي تؤثرعلى ال fertility أي
+
+11
+00:00:48,490 --> 00:00:52,270
+الخصوبة عند ال male و عند ال female و فيما سابق
+
+12
+00:00:52,270 --> 00:00:58,210
+تحدثنا عن ال IVF و تحدثنا عن ال IGC كانوك ذا بسيطة
+
+13
+00:00:58,210 --> 00:01:05,110
+عنه و توقفنا عند مصطلح جديد كيف يمكن الحصول على
+
+14
+00:01:05,110 --> 00:01:12,780
+baby أو كيف يمكن الحصول على حالة من الإنجابتحت
+
+15
+00:01:12,780 --> 00:01:18,140
+عنوان getting ready for pregnancy كيف يحدث الحميد
+
+16
+00:01:18,140 --> 00:01:24,760
+عند ال female وكيف يساهم نطف الرجل أو ال male على
+
+17
+00:01:24,760 --> 00:01:28,720
+الإتجار هنتكلم هلأ عدة أمور هنتكلم على ال
+
+18
+00:01:28,720 --> 00:01:33,780
+spermogenesis هنتكلم عن ال oogenesis كتعريفهم
+
+19
+00:01:33,780 --> 00:01:39,750
+أحداث بتصير في كلا العمليتين كيفتساهم عملية الـ
+
+20
+00:01:39,750 --> 00:01:43,770
+sperm metagenesis والتخليق النطف الذكرية في الحصول
+
+21
+00:01:43,770 --> 00:01:50,370
+على sperm mature قادر أن يلطح بويضة ناضجة هذه
+
+22
+00:01:50,370 --> 00:01:54,530
+البويضة تتحول إلى جنين، هذا الجنين يصبح
+
+23
+00:01:54,530 --> 00:02:00,240
+implementation في جدار الرحم للوصول إلىمولود كامل
+
+24
+00:02:00,240 --> 00:02:05,780
+بعد تسعة شهور أو سبعة شهور يناير على الحالة الخاصة
+
+25
+00:02:05,780 --> 00:02:11,600
+بالأنثى أو السيدة في نقاط بسيطة ان شاء الله سنتكلم
+
+26
+00:02:11,600 --> 00:02:17,500
+عن getting pregnancy بداية عملية ال pregnancy ليست
+
+27
+00:02:17,500 --> 00:02:22,200
+عملية سهلة بل هي عبارة عن عملية معقدة جدا جدا جدا
+
+28
+00:02:22,200 --> 00:02:27,240
+تمر بعدة مراحل و عدة أحداث و يشارك فيها الرجل
+
+29
+00:02:27,720 --> 00:02:32,780
+وتشارك فيها السيدة كلًا بجاميطته المقصود
+
+30
+00:02:32,780 --> 00:02:36,300
+بالجاميطات ال female gametes هي عبارة عن ال oocyte
+
+31
+00:02:36,300 --> 00:02:42,020
+و لازم تكون ضمن صفات معينة ومواصفات معينة حتى ضمن
+
+32
+00:02:42,020 --> 00:02:46,400
+Diameter معين وجاميطات الذكر اللي بنسميها male
+
+33
+00:02:46,400 --> 00:02:49,400
+gametes هي عبارة عن ال sperm و هذا ال sperm لازم
+
+34
+00:02:49,400 --> 00:02:53,600
+يكون completely normal أو بنسبة معينة طبعًا لما
+
+35
+00:02:53,600 --> 00:02:56,700
+نقول normal لما نحكي عن ال sperm من حيث ال
+
+36
+00:02:56,700 --> 00:02:59,760
+morphologyأما لحكي على الـ semen و هنتكلم عنه بشكل
+
+37
+00:02:59,760 --> 00:03:04,260
+مستفيد لازم يكون normal من حيث الـ count من حيث ال
+
+38
+00:03:04,260 --> 00:03:08,940
+motility و من حيث ال morphology علشان يصير في عنده
+
+39
+00:03:08,940 --> 00:03:12,880
+pregnancy و ال pregnancy should be pigance لازم
+
+40
+00:03:12,880 --> 00:03:17,240
+يصير عنده fusion ما بين ال sperm ال خاص بال male
+
+41
+00:03:17,240 --> 00:03:21,900
+مع ال oocyte الخاصة بال female وهذه عملية ال
+
+42
+00:03:21,900 --> 00:03:26,550
+fusion أو ال fertilization بالمصطلح العلميتحدث في
+
+43
+00:03:26,550 --> 00:03:29,730
+منطقة معينة من ال reproductive system عند الفيميل
+
+44
+00:03:29,730 --> 00:03:34,090
+وهي عبارة عن ال fallopian tube او reproductive
+
+45
+00:03:34,090 --> 00:03:38,810
+tract اذا صار في عندي fusion يعني صار في عندي اول
+
+46
+00:03:38,810 --> 00:03:42,910
+خطوة من خطوات ال pregnancy وعلشان يصير في عندي
+
+47
+00:03:42,910 --> 00:03:47,270
+pregnancy لازم يصير عندي steps اول حاجة both male
+
+48
+00:03:47,270 --> 00:03:51,290
+and female sex cell should be or must be passed
+
+49
+00:03:51,290 --> 00:03:57,310
+through a longseries of exchanges وهي اللي بنسميها
+
+50
+00:03:57,310 --> 00:04:01,510
+gematogenesis بمعنى أخر أنه أنا عندي male gemats و
+
+51
+00:04:01,510 --> 00:04:05,130
+female gemats هذه ال male و ال female gemats لازم
+
+52
+00:04:05,130 --> 00:04:08,810
+أنه يصير فيها عملية maturation للوصول إلى ال
+
+53
+00:04:08,810 --> 00:04:13,030
+formula أو ال form اللي بسمح لها بعملية التلقيح
+
+54
+00:04:13,030 --> 00:04:18,230
+هذه ال exchange اللي بتصير بنسميها mutagenesis أي
+
+55
+00:04:18,230 --> 00:04:23,820
+تخليق الجامتات تخليق عفوا بنسميهاGermetogenesis هي
+
+56
+00:04:23,820 --> 00:04:27,940
+عبارة عن تخليق الجميطات تسميها Germetogenesis وهي
+
+57
+00:04:27,940 --> 00:04:33,160
+عبارة عن عملية يتم فيها تحويل وتخليق الجميطات ولكي
+
+58
+00:04:33,160 --> 00:04:36,420
+تخلق الجميطات ال male و ال female germetes لازم
+
+59
+00:04:36,420 --> 00:04:40,660
+يصير في عندك convert لهم في ال genetic material في
+
+60
+00:04:40,660 --> 00:04:46,020
+الفينو تبقى structure عشان تصل لمثيور جميط وإذا
+
+61
+00:04:46,020 --> 00:04:50,580
+وصلت لمثيور جميط معناها سوف تكون قادرة حتما على ال
+
+62
+00:04:50,580 --> 00:04:54,500
+fertilizationبشرط أن تكون Normal من حيث الـ
+
+63
+00:04:54,500 --> 00:04:57,420
+Function لأن في عندي بعض الجميطات زي الـ Oocyte
+
+64
+00:04:57,420 --> 00:05:03,140
+جميط أو الـ spermatozoite أو الـ spermatozoa أو
+
+65
+00:05:03,140 --> 00:05:08,480
+الـ sperm بتكون phylotypically normal ولكن
+
+66
+00:05:08,480 --> 00:05:12,020
+functional abnormal فما بتقدر تعمل ال
+
+67
+00:05:12,020 --> 00:05:15,240
+fertilization هذه ال spermatozoa أو ال oocyte ما
+
+68
+00:05:15,240 --> 00:05:19,640
+بتقدر تستمر بعد عملية ال fertilization هذه إذا
+
+69
+00:05:19,640 --> 00:05:23,910
+كانت functionalغير طبيعية المرحلة التانية من
+
+70
+00:05:23,910 --> 00:05:29,070
+المراحل وهي عبارة عن بعد عملية الـ Gematogenesis
+
+71
+00:05:29,070 --> 00:05:34,370
+عملية التخليق لازم هذه الجميطات تنتقل من مكان
+
+72
+00:05:34,370 --> 00:05:38,770
+التخليق إلى مكان النضوج فبالتالي نستطيع أن نستوعب
+
+73
+00:05:38,770 --> 00:05:42,330
+و نفهم شيء هنا أن الـ place of production should
+
+74
+00:05:42,330 --> 00:05:45,290
+be separated from the place of storage and
+
+75
+00:05:45,290 --> 00:05:49,330
+saturation فبالتالي معناه أن الجميطات تخلق في مكان
+
+76
+00:05:49,800 --> 00:05:54,740
+وتنضج في مكان وتخصط في مكان آخر أو تستخدم في
+
+77
+00:05:54,740 --> 00:05:59,800
+التقسيد في مكان آخر فلو أنا أجهز على سبيل مثال على
+
+78
+00:05:59,800 --> 00:06:05,300
+الجناد الخاصة أو الـ Gematocyte الخاصة بالفيميل
+
+79
+00:06:05,300 --> 00:06:10,180
+حلاجيها تخلق في ال ovary و بيصير لها maturation في
+
+80
+00:06:10,180 --> 00:06:13,440
+ال ovary ولكن بيصير لها fertilization في ال
+
+81
+00:06:13,440 --> 00:06:17,400
+fallopian tube فبالتالي مكان ال maturation حتى في
+
+82
+00:06:17,400 --> 00:06:20,870
+ال ovary مكان ال maturationيختلف عن مكان الـ
+
+83
+00:06:20,870 --> 00:06:24,610
+formation لو أنا أتكلمت على الـ spermatocyte
+
+84
+00:06:24,610 --> 00:06:28,210
+هلاجيها تخلق في الـ testis وتنضج في الـ embedded
+
+85
+00:06:28,210 --> 00:06:32,510
+muscle وهو جوز من الـ testis تخلق في منطقة في الـ
+
+86
+00:06:32,510 --> 00:06:36,750
+testis، عن كلام أنا بالصورة و ثم بعد ذلك بيصيرها
+
+87
+00:06:36,750 --> 00:06:42,230
+ejaculation خارج جسم الإنسان علشان تستخدم في عملية
+
+88
+00:06:42,230 --> 00:06:46,170
+تلقيح البويضة الناضجة بـ fallopian tube هذه رحلة
+
+89
+00:06:46,170 --> 00:06:51,470
+طويلة جدايتم فيها انتقال ال sperm من ال male إلى
+
+90
+00:06:51,470 --> 00:06:54,370
+ال female لتلقح البقايدة واحنا نتكلم عنها بشكل
+
+91
+00:06:54,370 --> 00:06:57,890
+واضح جدا طب ليش هنتكلم عن هذا الموضوع؟ لأنه لازم
+
+92
+00:06:57,890 --> 00:07:01,790
+نفهم ال gematogenesis كيف تخلّح أي خلل في تخليق
+
+93
+00:07:01,790 --> 00:07:06,030
+الجمهيطات معناه فشل في ال fertilization فشل في ال
+
+94
+00:07:06,030 --> 00:07:11,990
+fertilization يعني غير .. غير قادرين على الحصول
+
+95
+00:07:11,990 --> 00:07:17,720
+على حالة من حالة pregnancyبالنسبة للموضوع الواضح
+
+96
+00:07:17,720 --> 00:07:23,940
+أن الوضع
+
+97
+00:07:23,940 --> 00:07:26,820
+يتنصف بالنسبة للموضوع الواضح ان الوضع يتنصف
+
+98
+00:07:26,820 --> 00:07:26,920
+بالنسبة للموضوع الواضح ان الوضع يتنصف بالنسبة
+
+99
+00:07:26,920 --> 00:07:26,980
+للموضوع الواضح ان الوضع يتنصف بالنسبة للموضوع
+
+100
+00:07:26,980 --> 00:07:28,800
+الواضح ان الوضع يتنصف بالنسبة للموضوع الواضح ان
+
+101
+00:07:28,800 --> 00:07:30,520
+الوضع يتنصف بالنسبة للموضوع الواضح ان الوضع يتنصف
+
+102
+00:07:30,520 --> 00:07:33,320
+بالنسبة للموضوع الواضح ان الوضع يتنصف بالنسبة
+
+103
+00:07:33,320 --> 00:07:37,100
+للموضوع الواضح ان الوضع يتنصف بالنسبة للموضوع
+
+104
+00:07:37,100 --> 00:07:42,970
+الواضح ان الوأي Oocyte بعد عملية التخصيب لازم
+
+105
+00:07:42,970 --> 00:07:47,650
+تُنقل بفعل السيليا على سبيل المثال بفعل القبضات
+
+106
+00:07:47,650 --> 00:07:51,510
+للعضلات اللي خاصة بال reproductive tract و ال
+
+107
+00:07:51,510 --> 00:07:54,870
+fallopian tube تنتقل من منطقة التلطيح و هي
+
+108
+00:07:54,870 --> 00:07:59,210
+fallopian tube فنشوف صورة في هذه عملية التلطيح
+
+109
+00:07:59,210 --> 00:08:02,970
+البويضة animation من منطقة التلطيح fallopian tube
+
+110
+00:08:02,970 --> 00:08:07,150
+إلى الرحم لكي تنغرز في بطارية الرحم تحت مصطلح
+
+111
+00:08:07,150 --> 00:08:13,420
+بتسميهimplantation هو عبارة عن انغراس أو الانغماس
+
+112
+00:08:13,420 --> 00:08:17,120
+فبصير في عندي انغماس البويضة الملقح في بطانة الرحم
+
+113
+00:08:17,120 --> 00:08:21,200
+والأم فيما بعد بتمدها أو الدورة الدموية الخاصة
+
+114
+00:08:21,200 --> 00:08:24,360
+بالأم بتمدها بكل المواد الغذائية لتكوين ال
+
+115
+00:08:24,360 --> 00:08:29,900
+placenta التي تعتبر مصدر ومدخل للغذاء ال
+
+116
+00:08:29,900 --> 00:08:33,760
+gematogenesis هل هي عبارة عن حدث واحد فقط لغير one
+
+117
+00:08:33,760 --> 00:08:37,960
+event one step ولا في different stepوهل ال male و
+
+118
+00:08:37,960 --> 00:08:41,780
+female gematogenesis مختلفين؟ أكيد مختلفين، لكن
+
+119
+00:08:41,780 --> 00:08:45,700
+لكي نبسط المعلومة، بما نستطيع أن نقول إن ال male
+
+120
+00:08:45,700 --> 00:08:50,100
+gematogenesis similar with male female
+
+121
+00:08:50,100 --> 00:08:55,680
+gematogenesis في only one phase هل هناك أطوار
+
+122
+00:08:55,680 --> 00:08:59,540
+أخرى؟ أكيد في عندي أربع أطوار أو أربع مراحل لتكوين
+
+123
+00:08:59,540 --> 00:09:03,380
+ال gematocyte أو ال gematogenesis العملية المرحلة
+
+124
+00:09:03,380 --> 00:09:07,500
+الأولى بنسميها extra-emperionic originalأو origin
+
+125
+00:09:07,500 --> 00:09:11,600
+of the germ cell and their migration into gonads
+
+126
+00:09:11,600 --> 00:09:17,180
+وهي عبارة عن عملية يتم فيها تخليق الجميطات في ال
+
+127
+00:09:17,180 --> 00:09:20,920
+embryo اللي بنسميها extra embryonic ليش سموها
+
+128
+00:09:20,920 --> 00:09:25,380
+extra embryonic؟ لأنها بتحدث خارج أو قبل تكوين ال
+
+129
+00:09:25,380 --> 00:09:29,640
+embryo بالشكل اللي احنا بنعرفه ثم بعد ذلك يتم
+
+130
+00:09:29,640 --> 00:09:34,320
+نقلها إلى منطقة الجناد في ناس تعرفها بمنطق أخر هي
+
+131
+00:09:34,320 --> 00:09:38,240
+عبارة .. بمنطق أخر هي عبارة عنتصنيع الجميطات في
+
+132
+00:09:38,240 --> 00:09:42,940
+غير مكانها يعني المفروض الجميل كالـ sperm يُصنع في
+
+133
+00:09:42,940 --> 00:09:46,660
+الـ testis وكالـ oocyte تُصنع في الـ ovary ولكن
+
+134
+00:09:46,660 --> 00:09:51,140
+أول مرحلة بنتسموها extra-embryonic وهي عبارة عن
+
+135
+00:09:51,140 --> 00:09:55,500
+عملية يتم فيها تصنيع الجميطات خارج منطقة الجنادى
+
+136
+00:09:55,500 --> 00:09:58,380
+الجنادى اللي بنتسميه ال reproductive system للـ
+
+137
+00:09:58,380 --> 00:10:02,000
+male أو reproductive system لل female ال ovary و
+
+138
+00:10:02,000 --> 00:10:06,450
+ال testis هذه المرحلة الأولىوهذه المرحلة تتشابه
+
+139
+00:10:06,450 --> 00:10:09,990
+عند الـ Male وعند الـ Female يليها ثلاث مراحل،
+
+140
+00:10:09,990 --> 00:10:13,610
+المرحلة التانية زيادة في عدد الـ Germ Cypin
+
+141
+00:10:13,610 --> 00:10:18,750
+استخدام انقسم ميتوزي يليه reduction in the
+
+142
+00:10:18,750 --> 00:10:22,530
+chromosome number في الـ Female والمال تحت انقسم
+
+143
+00:10:22,530 --> 00:10:26,370
+ميوزي وآخر الـ phase بنسميه Structural and
+
+144
+00:10:26,370 --> 00:10:30,130
+Functional Maturation of Oocyte and Sperm أربع
+
+145
+00:10:30,130 --> 00:10:35,380
+step الأولى هي عبارة عن تخليق الجميطخارج منطقة
+
+146
+00:10:35,380 --> 00:10:40,440
+الجونات بالسمية Extra-Empirionic Origin وهي تتشابه
+
+147
+00:10:40,440 --> 00:10:44,760
+عند الذكر والأنثى الـ three step الأخيرة تختلف عند
+
+148
+00:10:44,760 --> 00:10:48,460
+الذكر عن الأنثى وهي عبارة عن increase in the
+
+149
+00:10:48,460 --> 00:10:52,580
+number of germ cell من القسم الميتوزي reduction in
+
+150
+00:10:52,580 --> 00:10:55,840
+the chromosome number من القسم الميوزي بعدين
+
+151
+00:10:55,840 --> 00:10:59,020
+structural and functional macuration of oocyte
+
+152
+00:10:59,020 --> 00:11:04,700
+بأكد مرة أخرى أن التلتخطوات الأخيرة تختلف عند ال
+
+153
+00:11:04,700 --> 00:11:08,760
+male و عند ال female بينما الخطوة الأولى متشابهة
+
+154
+00:11:08,760 --> 00:11:13,160
+عند الذكر و المنتقل نيجي الخطوة خطوة الخطوة الأولى
+
+155
+00:11:13,160 --> 00:11:17,920
+اللى سمناها extra embryonic origin and migration
+
+156
+00:11:17,920 --> 00:11:23,520
+of germ cell to the gonadal place في خلاية بنسميها
+
+157
+00:11:23,520 --> 00:11:27,640
+الخلاية الأم زى الخلاية ال stem cell في خلاينا
+
+158
+00:11:27,640 --> 00:11:31,690
+جميعا في خلاية أم بنسميها stem cell ولكنالخلية
+
+159
+00:11:31,690 --> 00:11:36,130
+الأم الخاصة بالجميد عند الميل وعند الفيميل بسميها
+
+160
+00:11:36,130 --> 00:11:41,450
+PGS Primordial Germ Cell من اسم الجيرم سيل ولكن
+
+161
+00:11:41,450 --> 00:11:45,150
+ضافوا لها Primordial لإنها خلية الأم هذه الخلية
+
+162
+00:11:45,150 --> 00:11:48,170
+الأم اللي بتسميها Primordial Germ Cell واختصارها
+
+163
+00:11:48,170 --> 00:11:53,390
+PGS هي عبارة عن الخلية الأولى التي تظهر خلال عملية
+
+164
+00:11:53,390 --> 00:11:57,510
+تكوين الجميد فبنسميها Precursor Cell for Gemid
+
+165
+00:11:57,510 --> 00:12:01,930
+Formation أو Precursor Cell for Gemidهذه الخلايا
+
+166
+00:12:01,930 --> 00:12:07,610
+الـ BGS تظهر خارج الجناد وبعد أن تتكافر بأعداد
+
+167
+00:12:07,610 --> 00:12:11,930
+مناسبة بيصيرها migration لمنطقة الجناد وهذه
+
+168
+00:12:11,930 --> 00:12:15,870
+العملية بتصير في ال early embryonic development في
+
+169
+00:12:15,870 --> 00:12:21,930
+ال early embryonic development وهي أول شهور الحمل
+
+170
+00:12:21,930 --> 00:12:27,010
+على سبيل المثال حمل الذكر أو أنثى طبعا بيصير في
+
+171
+00:12:27,010 --> 00:12:32,680
+عين ديprimordial germ cell تبدأ تظهر في منطقة خارج
+
+172
+00:12:32,680 --> 00:12:37,900
+الجونات ثم عندما تكثر من حيث العدد تنتقل إلى منطقة
+
+173
+00:12:37,900 --> 00:12:41,800
+الجونات human primordial germ cell first become
+
+174
+00:12:41,800 --> 00:12:47,720
+pretty recognizable at 24 days after fertilization
+
+175
+00:12:47,720 --> 00:12:52,420
+يعني ببدأ أتعرف على هذه ال primordial germ cell
+
+176
+00:12:52,420 --> 00:12:56,590
+بعد 24 يوم من ال fertilizationلو صار فيها في عندي
+
+177
+00:12:56,590 --> 00:13:00,830
+fertilization aid 1,2,3 لحد اليوم الـ 24 بعد اليوم
+
+178
+00:13:00,830 --> 00:13:05,690
+الـ 24 تبدأ primordial germ cell تظهر و ببدأ أنا
+
+179
+00:13:05,690 --> 00:13:10,450
+أتعرف عليها in the endodermal layer of yolk sac
+
+180
+00:13:10,450 --> 00:13:14,570
+يوكساك زي المحي، بنسميه المحي من اللغة العربية
+
+181
+00:13:14,570 --> 00:13:18,190
+طبعا بتكون في ال size .. من حيث ال size very large
+
+182
+00:13:18,190 --> 00:13:22,940
+بتحتوي هذه الخلايا على كمية كبيرة جدامن الجليكوجين
+
+183
+00:13:22,940 --> 00:13:26,320
+وبعض الإنزيمات زي الـAlkaline Phosphatase طبعا هذا
+
+184
+00:13:26,320 --> 00:13:29,240
+الجليكوجين بيحافظ على شكله و بيحميها والAlkaline
+
+185
+00:13:29,240 --> 00:13:32,960
+Phosphatase بيلعب دور كبير جدا في الـmetabolic ال
+
+186
+00:13:32,960 --> 00:13:36,680
+process الخاصة بهذا الخلايا طبعا عملوا دراسة على
+
+187
+00:13:36,680 --> 00:13:40,760
+الماوس كمديول وجدوا أن فيه عنده حوالي 100 cell
+
+188
+00:13:40,760 --> 00:13:44,540
+موجودة أو تغادر، خلّيني أسمي الـyolk sac 100 cell
+
+189
+00:13:44,540 --> 00:13:48,730
+من الـprimordial germ cell تغادر اليوكساكوبتخضع
+
+190
+00:13:48,730 --> 00:13:51,150
+لانقسام الميتوزي المتكرر بيصير عندنا
+
+191
+00:13:51,150 --> 00:13:56,630
+multiplication حوالي 6 إلى 7 مرات الميت خلية بتصل
+
+192
+00:13:56,630 --> 00:14:01,210
+إلى 4000 خلية من حيث العدد وهذه بتسميها 4000
+
+193
+00:14:01,210 --> 00:14:04,630
+primordial germ cells will be entered the
+
+194
+00:14:04,630 --> 00:14:09,890
+embryonic colon هذه الميت خلية من دراسة حدثت على
+
+195
+00:14:09,890 --> 00:14:13,310
+الفقران وجدوا ان ميت خلية من ال primordial germ
+
+196
+00:14:13,310 --> 00:14:18,240
+cell موجودةفي هذه المنطقة أو تنتقل خلّيني أسميها
+
+197
+00:14:18,240 --> 00:14:22,540
+من منطقة اليوكساك إلى منطقة الجناد ولكن قبل أن
+
+198
+00:14:22,540 --> 00:14:27,080
+تنتقل لازم تخضع إلى المقسام الميتوزي حوالي 7 مرات
+
+199
+00:14:27,080 --> 00:14:32,940
+عشان يصل عددها إلى 4000 خلية هذه ال 4000 خلية هي
+
+200
+00:14:32,940 --> 00:14:37,020
+اللي بتدخل في منطقة ال embryonic جناد اللي بتسميها
+
+201
+00:14:37,020 --> 00:14:42,220
+primitive أو embryonic جناد علشان تبدأ صنع الجناد
+
+202
+00:14:43,460 --> 00:14:46,800
+عشان تبدأ تصنع الجناد الخاصة بالـ membrane تيجي
+
+203
+00:14:46,800 --> 00:14:49,300
+المرحلة التانية، طبعا هذه المرحلة similar in male
+
+204
+00:14:49,300 --> 00:14:52,540
+and female المرحلة التانية هي increasing the
+
+205
+00:14:52,540 --> 00:14:56,180
+number of germ cell by mitosis بعد ما تصل
+
+206
+00:14:56,180 --> 00:14:59,640
+لـprimordial germ cell الأربع ثلاث خلية، تصل
+
+207
+00:14:59,640 --> 00:15:03,960
+للجناد، primordial germ cell begin a phase of
+
+208
+00:15:03,960 --> 00:15:07,180
+rapidly mitotic proliferationأول ما تصل
+
+209
+00:15:07,180 --> 00:15:10,900
+الـprimordial germ cell إلى الجنات تبدأ في عملية
+
+210
+00:15:10,900 --> 00:15:14,720
+الانقسام الميتوزي المتكرر عشان يزيد العدد لأن
+
+211
+00:15:14,720 --> 00:15:18,220
+الورق في الأرض مش هيكوفن فبالتالي لازم يصير زيادة
+
+212
+00:15:18,220 --> 00:15:20,960
+في العدد زيادة في العدد معناه أنه لازم يصير في
+
+213
+00:15:20,960 --> 00:15:24,300
+عنده انقسام ميتوزي وعارفين أن انقسام الميتوزي من
+
+214
+00:15:24,300 --> 00:15:27,620
+المحاضرة السابقة ومن المعلومات السابقة اللي كنا
+
+215
+00:15:27,620 --> 00:15:31,140
+بنعرفها أن كل خلية بتدخل في انقسام الميتوزي تعطي
+
+216
+00:15:31,140 --> 00:15:36,770
+خليتين identical بنسميهم two daughter cellsفي الـ
+
+217
+00:15:36,770 --> 00:15:41,590
+Mitotic Division، كل خلية تعطي 2 diploid progen
+
+218
+00:15:41,590 --> 00:15:44,910
+that are genetically equal، عشان كده بنسميهم
+
+219
+00:15:44,910 --> 00:15:47,930
+daughter cells، تبقى إيش يعني diploid؟ يعني فيها
+
+220
+00:15:47,930 --> 00:15:51,610
+أزواج من الكروموزوم، إذا كان أنا في الخلية الأصلية
+
+221
+00:15:51,610 --> 00:15:54,710
+فيها عند اتنين كروموزوم، فبتعطيني خليتين كل خلية
+
+222
+00:15:54,710 --> 00:15:58,390
+فيها اتنين كروموزوم، diploid، الـ diploid منصف
+
+223
+00:15:58,390 --> 00:16:04,960
+لعدد الكروموزومطبعا بعد انقسام ميتوزي بشكل مستمر
+
+224
+00:16:04,960 --> 00:16:08,700
+وبشكل متتالي للـPrimordial Germ Cell اتصل من
+
+225
+00:16:08,700 --> 00:16:12,660
+hundred أو thousand إلى مليون لأن وجودنا مية خلية
+
+226
+00:16:12,660 --> 00:16:16,800
+في الفئران انقسموا انقسام ميتوزي ووصلوا أربع تلاف
+
+227
+00:16:16,800 --> 00:16:19,300
+للأربع تلاف انتقلوا إلى الـPrimordial Germ Cell
+
+228
+00:16:19,300 --> 00:16:21,740
+إلى الـGonad Place اللي بيسميها Embryonic Gonad
+
+229
+00:16:21,740 --> 00:16:25,220
+طبعا هذه تستمر في انقسام الميتوزي عشان اتصل
+
+230
+00:16:25,220 --> 00:16:28,950
+الملايين الخلاياهل هي الـ Primordial Germ Cell لها
+
+231
+00:16:28,950 --> 00:16:31,850
+علاقة بالـ Oocyte و الـ Spermatocyte؟ أكيد عشان
+
+232
+00:16:31,850 --> 00:16:34,690
+كده لازم تصير ملايين عشان هتخدم ال male و ال
+
+233
+00:16:34,690 --> 00:16:37,730
+female طيلة فترة حياته من الخمسين أو الستين أو
+
+234
+00:16:37,730 --> 00:16:41,810
+السمعين سنة طبعا في الـ Mitotic Preliberation في
+
+235
+00:16:41,810 --> 00:16:44,650
+بعض ال different mark عند ال male و عند ال female
+
+236
+00:16:44,650 --> 00:16:48,710
+germ cell هنتكلم عنها يعني كيف ال male بتختلف عن
+
+237
+00:16:48,710 --> 00:16:51,850
+ال female أو كيف ال male يختلف عن ال female في
+
+238
+00:16:51,850 --> 00:16:55,610
+الإنقسام الميتوذي هنتكلم عنه في mark معين و site
+
+239
+00:16:55,610 --> 00:17:01,720
+معينبداية الـ mitotic active germ cell في الفيميل
+
+240
+00:17:01,720 --> 00:17:06,220
+بنسميها Ogonia يعني الخلايا اللي دخلت القسم
+
+241
+00:17:06,220 --> 00:17:11,200
+الميتوزي عند الفيميل وصارت بالملايين بسميها Ogonia
+
+242
+00:17:11,200 --> 00:17:16,500
+which is going through a period of mitotic
+
+243
+00:17:16,500 --> 00:17:19,840
+activity in the embryonic ovary from the second
+
+244
+00:17:19,840 --> 00:17:24,280
+throat to the fifth mouth of pregnancy in the
+
+245
+00:17:24,280 --> 00:17:28,330
+humanاللي بتفهمه من هذه الإبارة إن الـ Ogonia
+
+246
+00:17:28,330 --> 00:17:34,050
+تستمر في الإنقسام الميتوزي من الشهر التاني لعمر
+
+247
+00:17:34,050 --> 00:17:38,210
+الجنين حتى الشهر الخامس بعد كده مافيش حاجة اسمها
+
+248
+00:17:38,210 --> 00:17:41,750
+Ogonia أو بمعنى آخر بعد كده بتتوقف الإنقسام
+
+249
+00:17:41,750 --> 00:17:45,290
+الميتوزي إذا بالنسبة لل female وهذا أول نقاط
+
+250
+00:17:45,290 --> 00:17:49,090
+الإختلاف ما بين ال male و ال female في الحدث
+
+251
+00:17:49,090 --> 00:17:54,100
+التاني أو ال phase التانيمن تكوين الجميطات إن الـ
+
+252
+00:17:54,100 --> 00:17:59,520
+Female تستمر عملية الانقسام الميتوزي بشكل تبدأ في
+
+253
+00:17:59,520 --> 00:18:03,240
+الشهر الثاني من الحمل أو الشهر الثاني من عمر
+
+254
+00:18:03,240 --> 00:18:08,000
+الجنين حتى الشهر الخامس يعني بمجرد الجنين يدخل
+
+255
+00:18:08,000 --> 00:18:11,720
+الشهر الخامس الانقسام الميتوزي إذا كان الجنين
+
+256
+00:18:11,720 --> 00:18:18,580
+Female بتوقف هذه النقطة الأولى طيب بالنسبة ل ..
+
+257
+00:18:18,580 --> 00:18:22,830
+أنا خلصت بالنسبة لنقطة الأولىطبعا خلال هذه الشهرين
+
+258
+00:18:22,830 --> 00:18:26,810
+إلى خمس شهور الـ Primordial Germ Cell بزيد عددها
+
+259
+00:18:26,810 --> 00:18:30,470
+بشكل كبير جدا تصل إلى ملايين تصل عند ال female
+
+260
+00:18:30,470 --> 00:18:35,230
+تقريبا سبعة مليون خلية هذه سبعة مليون خلية هيتطور
+
+261
+00:18:35,230 --> 00:18:41,430
+ويعطوني سبعة مليون OocyteThe number represent the
+
+262
+00:18:41,430 --> 00:18:45,190
+maximum number of germ cells that are even bound
+
+263
+00:18:45,190 --> 00:18:49,590
+in ovary يعني هدول السبعة مليون germ cell هيتطوروا
+
+264
+00:18:49,590 --> 00:18:53,830
+إلى سبعة مليون oocyte وهي بتمثل عدد البويضات في ال
+
+265
+00:18:53,830 --> 00:18:58,230
+ovary طبعا لما أقول ovaries كل سيدة في عندها مبيض
+
+266
+00:18:58,230 --> 00:19:02,030
+على اليمين ومبيض على اليسار محصل البويضات الموجودة
+
+267
+00:19:02,030 --> 00:19:07,190
+في كل المبيضات سبعة مليون بويضة أو سبعة مليون
+
+268
+00:19:07,450 --> 00:19:11,370
+Primordial Gerbsinia طبعا ما بيبقوا 7 مليون وما
+
+269
+00:19:11,370 --> 00:19:15,310
+بيستمروا 7 مليون لإنه بيدخلوا في مراحل الاببتواسيس
+
+270
+00:19:15,310 --> 00:19:20,990
+فيما بعد طبعا خلال هذه الفترة الـ Ogonia بتدخل في
+
+271
+00:19:20,990 --> 00:19:26,590
+مرحلة بتسميها Natural Degeneration أو التدمير
+
+272
+00:19:26,590 --> 00:19:30,630
+الطبيعي إنه كل خلية إلى half-life معين بعد كده لم
+
+273
+00:19:30,630 --> 00:19:35,470
+تستعمل بصيلها تدمير بسميها هذه العملية الـ Trachea
+
+274
+00:19:35,660 --> 00:19:40,080
+إذا الـ Atresia هي عبارة عن تدمير طبيعي للـ Ogonia
+
+275
+00:19:40,080 --> 00:19:44,880
+تدمير طبيعي للـ Ogonia .. للـ Ogonia بينما الـ
+
+276
+00:19:44,880 --> 00:19:48,480
+Atresia في مرحلة تانية بتشبه الـ Menstrual Cycle
+
+277
+00:19:48,480 --> 00:19:52,380
+أو الدورة الخاصة بالسيدة لأنه مافي مقحت البويضة
+
+278
+00:19:52,380 --> 00:19:57,520
+فتنزل مع بطاقة الرحل في حالة البلد أما الـ Ogonia
+
+279
+00:19:57,520 --> 00:20:01,980
+تدخل مرحلة Apoptosis أو الـ Degeneration طبيعية
+
+280
+00:20:01,980 --> 00:20:05,360
+بسمي هذا الـ Degeneration طبيعية Atresiaطبعا
+
+281
+00:20:05,360 --> 00:20:13,160
+الاتراجيا تستمر خلال فترة حياة الأنثى من و هي جنين
+
+282
+00:20:13,160 --> 00:20:18,260
+حتى تصل مرحلة الـ monobiosis هي اتراجيا بشكل مستمر
+
+283
+00:20:18,260 --> 00:20:24,200
+و بشكل شهري و إلا كيف السيدة هتتخلص من الـ 7 مليون
+
+284
+00:20:24,200 --> 00:20:30,520
+بوايضة أو 7 مليون جرسل هذه
+
+285
+00:20:30,520 --> 00:20:34,240
+الصورة بتبين لي الاتراجيا اللي بتصير من لحظة
+
+286
+00:20:35,710 --> 00:20:40,190
+الاخصاب مرورا بلحظة الميلاد يعني الفترة الجانبية
+
+287
+00:20:40,190 --> 00:20:45,510
+مرورا بلحظة الميلاد وصولا إلى مرحلة الـ monobios
+
+288
+00:20:45,510 --> 00:20:49,850
+طبعا في عند اللون الـ yellow أو الذهبي نسميها
+
+289
+00:20:49,850 --> 00:20:54,010
+follicular pool اللون الأخضر الأتراجيا اللي بيصير
+
+290
+00:20:54,010 --> 00:20:57,190
+فيها degeneration اللون ال purple هي ال growing
+
+291
+00:20:57,190 --> 00:21:00,470
+follicle المرحلة اللي بيصير فيها تطور الخلايا و
+
+292
+00:21:00,470 --> 00:21:04,610
+اللون اللي باللون ال redأو الـ Kermidi هي عبارة عن
+
+293
+00:21:04,610 --> 00:21:06,850
+الـ ovulated follicle هي المرحلة اللي بيصل فيها
+
+294
+00:21:06,850 --> 00:21:11,230
+ovulation طبعا فيها دياجرام بيمثل ال years وبيمثل
+
+295
+00:21:11,230 --> 00:21:15,270
+ال number of germ cell خلال فترات الحياة في أول
+
+296
+00:21:15,270 --> 00:21:22,910
+فترات الحياة قبل سن الرشد أو 15 أو 16 سنة كواتبار
+
+297
+00:21:22,910 --> 00:21:27,270
+السن بيصل فيها اندي كمية كبيرة جدا من ال follicle
+
+298
+00:21:27,270 --> 00:21:31,610
+folds لأن ال follicle أو ال germ cell بتكون زي ما
+
+299
+00:21:31,610 --> 00:21:36,610
+هيفي حالة خمول وفي حالة .. زي حاجة بتسميها
+
+300
+00:21:36,610 --> 00:21:41,770
+arrested phase و بصير في هذه المرحلة atresia بشكل
+
+301
+00:21:41,770 --> 00:21:46,890
+واضح جدا لما بعد سن الرشد او مقصير adult من 20 ل
+
+302
+00:21:46,890 --> 00:21:52,030
+30 او ل 35 بلاقي انا في عندي atresia زادت بشكل
+
+303
+00:21:52,030 --> 00:21:56,710
+ملحوظ طبعا زيادة ال atresia معناه هيصير في عندي
+
+304
+00:21:56,710 --> 00:22:01,290
+نقصان في ال follicular pool عشان كده اللون الدهبي
+
+305
+00:22:01,290 --> 00:22:06,560
+بلاقيه بقلفي المقابل، سيكون في عندي Folicle Growth
+
+306
+00:22:06,560 --> 00:22:10,800
+علشان الدورة أو الـ Menstrual Cycle وفي عندي
+
+307
+00:22:10,800 --> 00:22:14,680
+Ovulated Follicle بدأت تظهر طبعا هذا العمر من 20
+
+308
+00:22:14,680 --> 00:22:22,780
+أو من 15 حتى 35 من 40 فما فوق، بلاقي كل المرحلة
+
+309
+00:22:22,780 --> 00:22:29,880
+هذه كلها Atragia كمية قليلة جدا جدا جدا هي عبارة
+
+310
+00:22:29,880 --> 00:22:33,900
+عن Ovulated Follicleلأن في هذه المرحلة، مرحلة الـ
+
+311
+00:22:33,900 --> 00:22:37,940
+post-monobiose أو الـ monobiosal مافي عندى
+
+312
+00:22:37,940 --> 00:22:41,720
+bleeding بيصير، مافي عندى menstrual cycle بيصير
+
+313
+00:22:41,720 --> 00:22:46,180
+إلا بكمية قليلة جدا في السيدات، بنسبة قليلة جدا
+
+314
+00:22:46,180 --> 00:22:50,420
+بعد الـ 40 أو بعد الـ 45 طب ليش ما بيصير في عندى
+
+315
+00:22:50,420 --> 00:22:54,180
+ovulated follicle أو ما بيصير عندى menstrual
+
+316
+00:22:54,180 --> 00:22:57,960
+cycle؟ لأن كل الـ follicle الموجودة أو ال germ
+
+317
+00:22:57,960 --> 00:23:02,350
+cell الموجودة أو القوائدات الموجودة تم استهلاكهاو
+
+318
+00:23:02,350 --> 00:23:08,050
+جزء كبير منها دخل في مرحلة الـ Atresia فبلاجي مخزن
+
+319
+00:23:08,050 --> 00:23:13,610
+البويضات الـ ovary تكون محصلة المخزون فيه تكاد
+
+320
+00:23:13,610 --> 00:23:18,270
+تكون منعدمة فما تصير عنده menstrual cycle بالإضافة
+
+321
+00:23:18,270 --> 00:23:21,790
+إلى إن الهرمونات تصير في عنده fluctuation في مستوى
+
+322
+00:23:21,790 --> 00:23:25,950
+الهرمونات أو في كفاءة الـ Receptor إذا الـ Atresia
+
+323
+00:23:25,950 --> 00:23:31,590
+بتكون واضحة قبل عملية البلوأزداد بشكل ملحوظ جدا
+
+324
+00:23:31,590 --> 00:23:35,710
+بعد البلوك في مرحلة الأضغط تكون هي المسيطرة على
+
+325
+00:23:35,710 --> 00:23:40,670
+حياة السيدة بعد ال post-menopausal stage فبتصير هي
+
+326
+00:23:40,670 --> 00:23:45,470
+اللي بتاخد أكبر حيز من الأحداث، lethargy انقسام
+
+327
+00:23:45,470 --> 00:23:49,950
+الميتوزي عند الذكور كمان أنا حكيت عند الاناث بتبقى
+
+328
+00:23:49,950 --> 00:23:54,010
+في الشهر التاني للشهر الخامس من عمر الجنين للأنثى
+
+329
+00:23:54,010 --> 00:23:58,610
+عند الذكور يختلف، فألاقي أن انقسام الميتوزي عند
+
+330
+00:23:58,610 --> 00:24:03,510
+الذكورببدأ بشكل مبكر جدا من مرحلة الـ Empyrionic
+
+331
+00:24:03,510 --> 00:24:08,210
+Testes ولكن بتوجه في الـ Second Trimester يعني
+
+332
+00:24:08,210 --> 00:24:11,950
+بداية ال Second Trimester بتوجه في بداية ال Second
+
+333
+00:24:11,950 --> 00:24:15,330
+Trimester لإنوا عارفين الحمل يقص تسعة شهور يقسم
+
+334
+00:24:15,330 --> 00:24:20,170
+First, Second, Third Trimester تلت شهور الأولى،
+
+335
+00:24:20,170 --> 00:24:23,730
+تلت شهور التانية، تلت شهور الأخيرة من واحد لدلده،
+
+336
+00:24:23,730 --> 00:24:28,330
+من أربع على ستة ومن سبعة تمانية تسعة لل Third
+
+337
+00:24:28,330 --> 00:24:34,170
+Trimesterأو بتسميه ال third أو ال trimester طبعا
+
+338
+00:24:34,170 --> 00:24:37,510
+ال third trimester في ال second trimester يعني
+
+339
+00:24:37,510 --> 00:24:41,110
+بمعنى آخر في نهاية الشهر التالت من الحمل إذا كان
+
+340
+00:24:41,110 --> 00:24:45,770
+الجنين ذكر بتوقف الانقسام الميتوزي و بظل انقسام
+
+341
+00:24:45,770 --> 00:24:54,050
+الميتوزي متوقف and does not resume until حتى ال
+
+342
+00:24:54,050 --> 00:24:57,970
+blueيعني بمعنى آخر إن الإنقسام الميتوزي بتوقف عند
+
+343
+00:24:57,970 --> 00:25:04,350
+الجنين الذكر من بداية الـ second trimester حتى سن
+
+344
+00:25:04,350 --> 00:25:07,190
+البلوك بمجرد ما يصل الذكر لسن البلوك بيبدأ
+
+345
+00:25:07,190 --> 00:25:11,410
+الإنقسام الميتوزي يشتغل ويستمر مرة أخرى in
+
+346
+00:25:11,410 --> 00:25:14,070
+contrast to female germ cell male germ cell
+
+347
+00:25:14,070 --> 00:25:16,410
+maintains the ability to divide throughout
+
+348
+00:25:16,410 --> 00:25:21,270
+postnatal life بمعنى آخر إن ال germ cell الخاصة
+
+349
+00:25:21,270 --> 00:25:27,120
+بالذكر تستمر في الإنقسامطيلة فترة حياته، طيلة فترة
+
+350
+00:25:27,120 --> 00:25:30,280
+حياته، عشان كده بلاجي ال male بعد الخمسين و بعد
+
+351
+00:25:30,280 --> 00:25:33,720
+الستين و بعد السبعين، فيه عندهم spermatocyte و
+
+352
+00:25:33,720 --> 00:25:36,660
+spermateid، فيه عندهم spermatozoa و فيه عندهم
+
+353
+00:25:36,660 --> 00:25:40,680
+sperm، هذه كلها مصطلحات لل sperm، بينما ال female
+
+354
+00:25:40,680 --> 00:25:44,060
+مابلاجي عندها oocyte بعد الخمسة و أربعين، نادر جدا
+
+355
+00:25:45,290 --> 00:25:48,030
+طبعا في منطقة في الـ testes endymal بنتسميها الـ
+
+356
+00:25:48,030 --> 00:25:52,670
+semi-nervostipule هي المنطقة المصنع المصنع اللي
+
+357
+00:25:52,670 --> 00:25:56,670
+بتتم فيها تصنيع ال sperm metocyte اللي بنتسميه
+
+358
+00:25:56,670 --> 00:26:00,890
+spermatogonia sperm metocyte أو ال sperm لما يكون
+
+359
+00:26:00,890 --> 00:26:05,190
+في منطقة ال seminal .. seminal .. semen .. nervous
+
+360
+00:26:05,190 --> 00:26:10,570
+tipule بسميه spermatogoniaفي بداية سن البلوغ الـ
+
+361
+00:26:10,570 --> 00:26:14,270
+spermatogonium بتمر بعدة مراحل من التغيرات من
+
+362
+00:26:14,270 --> 00:26:20,330
+القسم الميتوزي علشان تتحول من spermatogonium إلى
+
+363
+00:26:20,330 --> 00:26:25,690
+sperm .. إلى sperm وهذه العملية بتظل مستمرة طول
+
+364
+00:26:25,690 --> 00:26:32,290
+فترة حياة الذكر .. طول فترة حياة الذكر نجي للحدث
+
+365
+00:26:32,290 --> 00:26:36,130
+التالت اللي بيصير وهو عبارة عن reduction in the
+
+366
+00:26:36,130 --> 00:26:39,940
+chromosome numberطبعا عشان أقول reduction إذا لازم
+
+367
+00:26:39,940 --> 00:26:44,380
+يكون فيها انقسام منصف وانقسام المنصف هو عبارة عن
+
+368
+00:26:44,380 --> 00:26:50,120
+انقسام الميوزي وده انقسام ميوز عارفين ان خلية
+
+369
+00:26:50,120 --> 00:26:54,280
+بتكون فيها اتنين chromosome تعطيني خليتين كل واحدة
+
+370
+00:26:54,280 --> 00:26:57,580
+فيها واحد chromosome نسميها خلية فيها اتنين N
+
+371
+00:26:57,580 --> 00:27:01,440
+تعطيني two cell كل واحدة فيها one N عشان كده
+
+372
+00:27:01,440 --> 00:27:06,260
+بنسميه انقسام منصف او ميوزيطبعا ال biological
+
+373
+00:27:06,260 --> 00:27:10,080
+significance of meiosis should be or will be
+
+374
+00:27:10,080 --> 00:27:13,220
+summarized as the following عشان أصبح عندي انقسام
+
+375
+00:27:13,220 --> 00:27:17,300
+ميوزي لازم أن ألخصه في أكثر من نقطة النقطة الأولى
+
+376
+00:27:17,300 --> 00:27:20,760
+نقطة ال reduction وإيش بيصير في ال reduction أنه
+
+377
+00:27:20,760 --> 00:27:26,040
+في عندى خلية تحتوي على deploy 2N أو 2S المقصود
+
+378
+00:27:26,040 --> 00:27:30,120
+بالـ2N هي الـ2 كروموزوم الـS اختصارا لكروموزوم
+
+379
+00:27:30,120 --> 00:27:35,120
+هتنقسم لتعطي خليتك و الخلية فيها 1N اللي بنسميه
+
+380
+00:27:35,280 --> 00:27:38,760
+Heploid So that the kind number of chromosome can
+
+381
+00:27:38,760 --> 00:27:42,380
+be maintained from generation to generation بهذه
+
+382
+00:27:42,380 --> 00:27:47,000
+القالية قالية ال reduction التي تتبع انقسام
+
+383
+00:27:47,000 --> 00:27:52,280
+الميوزي بتم المحافظة على المادة الوراثية و
+
+384
+00:27:52,280 --> 00:27:55,720
+الكرموزومات لكي تنتقل من generation ل generation
+
+385
+00:27:55,720 --> 00:28:00,540
+لذلك هذه أول مرحلة من المراحل الميوزي يليها
+
+386
+00:28:00,540 --> 00:28:03,860
+independent أو حاجة نسميها
+
+387
+00:28:07,790 --> 00:28:11,630
+resortment أي بمعنى أخر إعادة التجميع إعادة
+
+388
+00:28:11,630 --> 00:28:15,090
+التجميع إيش بمعنى إعادة التجميع؟ إنه في عنده
+
+389
+00:28:15,090 --> 00:28:18,410
+جامطات من الذكر و هي المادة الوراثية اللي جاي من
+
+390
+00:28:18,410 --> 00:28:22,530
+ال sperm و جامطات من الأنثة و هي المادة الوراثية
+
+391
+00:28:22,530 --> 00:28:25,450
+اللي جاي من الأنثة كرموزومات ذكرية و كرموزومات
+
+392
+00:28:25,450 --> 00:28:30,270
+أنثوية لازم يجتمعوا مع بعض و يصير mix ما بينهم و
+
+393
+00:28:30,270 --> 00:28:34,890
+تبادل للمادة الوراثية هذا بنسميها التجميع الغير
+
+394
+00:28:34,890 --> 00:28:42,170
+معتمديعني ما بيتمد على شيء بيدفعه بيصير بشكل مستقل
+
+395
+00:28:42,170 --> 00:28:45,670
+independent بعد كده بيصير حاجة بيسميها
+
+396
+00:28:45,670 --> 00:28:50,010
+redistribution
+
+397
+00:28:50,010 --> 00:28:54,550
+يعني إعادة التوزيع سبحان الله في مناطق على
+
+398
+00:28:54,550 --> 00:28:57,690
+الكرومزومات ال male و الكرومزومات ال female
+
+399
+00:28:57,690 --> 00:29:03,110
+متشابهة فبصير تبديل المنطقة هذه بتروح كرومزوم
+
+400
+00:29:03,110 --> 00:29:06,080
+الأولىو المنطقة هي دي نفسها اللي موجودة على
+
+401
+00:29:06,080 --> 00:29:10,020
+كرومزوم الأنثى بتروح كرومزوم الذكر تحت مصطلح
+
+402
+00:29:10,020 --> 00:29:13,040
+redistribution redistribution for what?
+
+403
+00:29:13,400 --> 00:29:16,320
+redistribution for maternal and paternal genetic
+
+404
+00:29:16,320 --> 00:29:20,640
+information through this process called crossing
+
+405
+00:29:20,640 --> 00:29:25,280
+over اللي كنا ناس نسميها فيما سبق التصالب العبور
+
+406
+00:29:25,280 --> 00:29:29,460
+إيش التصالب العبور؟ ببساطة جدا أي كرومزوم في عنده
+
+407
+00:29:29,460 --> 00:29:33,380
+عبارة عن two sister chromatid two sister chromatid
+
+408
+00:29:33,860 --> 00:29:38,200
+لو الكرموزوم رقم واحد في الذكر بيجي في الكرموزوم
+
+409
+00:29:38,200 --> 00:29:42,140
+رقم واحد في الأنثى متقابلين ال sister chromatid
+
+410
+00:29:42,140 --> 00:29:46,000
+الداخلي في نقاط ومناطق معينة متشابهة على كيلو
+
+411
+00:29:46,000 --> 00:29:51,600
+الكرموزوم بتم تبادلهم تحت مصطلح redistribution أو
+
+412
+00:29:51,600 --> 00:29:56,620
+crossing over on a major compound of the first
+
+413
+00:29:56,620 --> 00:30:00,660
+meiotic division is genetic recombination takes a
+
+414
+00:30:00,660 --> 00:30:06,330
+changeمن المادة
+
+415
+00:30:06,330 --> 00:30:10,230
+الوراثية أو مناطق معينة موجودة على الكرموزوم بتتم
+
+416
+00:30:10,230 --> 00:30:16,170
+تبادلهم في السيستر كرماتية الداخل One form of
+
+417
+00:30:16,170 --> 00:30:20,170
+recombination which typically occur early in the
+
+418
+00:30:20,170 --> 00:30:22,850
+prophase involve short segments and occur through
+
+419
+00:30:22,850 --> 00:30:27,660
+the mechanism similar to the anaerobicأحد صفات الـ
+
+420
+00:30:27,660 --> 00:30:32,060
+Redistribution أو الـ Recombination إن قطعة معينة
+
+421
+00:30:32,060 --> 00:30:35,800
+موجودة على الـ Male أو الـ Female كروموزوم نفس
+
+422
+00:30:35,800 --> 00:30:38,220
+الكروموزوم طبعاً لما نقول كروموزوم 1 عند الـ Male
+
+423
+00:30:38,220 --> 00:30:40,620
+و الـ Female أو كروموزوم 8 عند الـ Male و الـ
+
+424
+00:30:40,620 --> 00:30:45,520
+Female تصير تبادل لهذه القطعة بمصطلح يشبه إلى حد
+
+425
+00:30:45,520 --> 00:30:49,820
+ما مصطلح التصاريف العجول وتشبه إلى حد ما حاجة
+
+426
+00:30:49,820 --> 00:30:53,500
+بنسميها الـ DNA repair شو يعني الـ DNA repair؟
+
+427
+00:30:53,500 --> 00:30:58,190
+يعني تصليح الأخطاقهل في أخطاء بتصير؟ هو يعتبر
+
+428
+00:30:58,190 --> 00:31:02,910
+انتقال القطعة من كروموزوم الأب إلى كروموزوم الأم
+
+429
+00:31:02,910 --> 00:31:06,350
+وانتقال نفس القطعة من كروموزوم الأم إلى كروموزوم
+
+430
+00:31:06,350 --> 00:31:09,810
+الأب هي عبارة عن عملية قطع وعادة لصق فهي عبارة عن
+
+431
+00:31:09,810 --> 00:31:13,550
+repair وبعض الأحيان بيعمل check up عشان يتأكد إن
+
+432
+00:31:13,550 --> 00:31:17,270
+نفس القطعة نقلت أو لا طبعا هذه العملية عملية
+
+433
+00:31:17,270 --> 00:31:21,170
+crossing over أو redistribution بتصير في stage
+
+434
+00:31:21,170 --> 00:31:27,450
+معين بنسمي Pactin stage أيضاهذه العملية لا تحدث
+
+435
+00:31:27,450 --> 00:31:31,810
+على الـ autosome للكرموزوم و هي الكرموزوم الجسدية
+
+436
+00:31:31,810 --> 00:31:36,330
+لها تحدث على 6 كرموزوم زي ال X و ال Y معقول هل في
+
+437
+00:31:36,330 --> 00:31:39,750
+مناطق على ال X تشبه المناطق الموجودة على ال Y؟
+
+438
+00:31:39,750 --> 00:31:43,550
+صحيح، في مناطق على ال X تتشبه مع المناطق الموجودة
+
+439
+00:31:43,550 --> 00:31:48,450
+على ال Y و هي عبارة عن مناطق حيوية ولكن لا تدخل في
+
+440
+00:31:48,450 --> 00:31:51,810
+تحديد جلس المولودفي هذه المناطق بيصير لها crossing
+
+441
+00:31:51,810 --> 00:31:56,790
+over أو redistribution أو استبدال crossing over is
+
+442
+00:31:56,790 --> 00:32:01,550
+not okay و randomly طبعا هذه عملية التصالب والعبور
+
+443
+00:32:01,550 --> 00:32:06,830
+أو عملية تبادل القطع ما بتصير بشكل عشوائي لأ بتصير
+
+444
+00:32:06,830 --> 00:32:11,970
+تحت control بشكل عالي جدا بطريقة مرتبة جدا في
+
+445
+00:32:11,970 --> 00:32:15,390
+مناطق معينة جدا هذه المناطق في الغالب بيسموها hot
+
+446
+00:32:15,390 --> 00:32:19,010
+spot على الكروبوزونما في حاجة بتصير داخل جسم
+
+447
+00:32:19,010 --> 00:32:24,870
+الإنسان بشكل عشوائي أو بشكل تلقائي في الوضع
+
+448
+00:32:24,870 --> 00:32:32,110
+الطبيعي طبعا هذه صورة بتوضحلي الـ Pro phase وهو
+
+449
+00:32:32,110 --> 00:32:37,390
+عبارة عن انقسام أو طور من أطوار انقسام الميوزي لو
+
+450
+00:32:37,390 --> 00:32:41,290
+أنا جيت للطور التالت الـ Actin Stage اللي بيصير
+
+451
+00:32:41,290 --> 00:32:45,270
+فيه التصالب و العبور وعبارة عن أحد الأطوار اللي
+
+452
+00:32:45,270 --> 00:32:48,860
+بيصير فيها ال crossing overيأتي مباشرة بعد تكوين
+
+453
+00:32:48,860 --> 00:32:53,680
+الزيجوت طب شو هي الزيجوت؟ الزيجوت هي اندماج النواة
+
+454
+00:32:53,680 --> 00:32:57,900
+الخاصة بالـ Spear مع النواة الخاصة بالـ Oocyte
+
+455
+00:32:57,900 --> 00:33:03,620
+لتكوين نواة واحدة بنسميها زيجوت أو الزيجوت هي
+
+456
+00:33:03,620 --> 00:33:09,160
+عبارة عن خلية تحتوي على نواة واحدة هذه النواة تنتج
+
+457
+00:33:09,160 --> 00:33:12,660
+من اندماج المادة الوراثية الخاصة بالأرض مع المادة
+
+458
+00:33:12,660 --> 00:33:17,760
+الوراثية الخاصة بالأرض فبسميها زيجوتأسميها زي ما
+
+459
+00:33:17,760 --> 00:33:23,120
+ترونها طبعاً موقعها يعتمد على تنظيم البروتين التي
+
+460
+00:33:23,120 --> 00:33:28,600
+أُرغنزت كروموزوم في ميوسيس فهذه العملية و المناطق
+
+461
+00:33:28,600 --> 00:33:32,720
+اللي بيصير فيها الـ crossing over تعتمد على درجة
+
+462
+00:33:32,720 --> 00:33:38,080
+عالية من الكرتير و التأكد و تكتب بروتينات معينة
+
+463
+00:33:38,080 --> 00:33:41,600
+مسؤولة عن عملية العملية من أشهر هذه العملية التي
+
+464
+00:33:41,600 --> 00:33:46,880
+تعمل علىإتمام عملية الـ crossing over بروتين نسميه
+
+465
+00:33:46,880 --> 00:33:53,120
+cohesin protein من أشهر البروتينات التي تساعد على
+
+466
+00:33:53,120 --> 00:33:58,040
+إتمام و بدء الـ crossing over حيث تساعد على ربط
+
+467
+00:33:58,040 --> 00:34:01,240
+الـ two sister chromatid مع بعض و مع البعض two
+
+468
+00:34:01,240 --> 00:34:04,840
+sister chromatid عفوا المقصود في hold sister
+
+469
+00:34:04,840 --> 00:34:07,000
+chromatid together during division لما أقول two
+
+470
+00:34:07,000 --> 00:34:09,860
+sister chromatid يعني كل كرمزوم في two sister
+
+471
+00:34:09,860 --> 00:34:12,910
+chromatid لما أجيب كرمزوم واحد من الأبمع كرموزوم
+
+472
+00:34:12,910 --> 00:34:18,710
+واحد من الـ O لازم يصطفوا أمام بعض بشكل متوازي
+
+473
+00:34:18,710 --> 00:34:22,010
+وبعدين ييجي الـ sister الكرمتيد الداخلي الخاص
+
+474
+00:34:22,010 --> 00:34:24,730
+بالأب مع ال sister الكرمتيد الداخلي الخاص بالأم
+
+475
+00:34:24,730 --> 00:34:28,330
+بيصير فيهم crossing over طبعا البروتين اللي بيقوم
+
+476
+00:34:28,330 --> 00:34:33,550
+بعملية الاصطفاف البروتين بنسميه cohesin protein في
+
+477
+00:34:33,550 --> 00:34:36,710
+عملية تانية بنسميها hypermethylation هذه الـ
+
+478
+00:34:36,710 --> 00:34:39,990
+hypermethylation بتصير على ال DNA وبتصير على ال
+
+479
+00:34:39,990 --> 00:34:43,070
+بيستون والبيستون هو عبارة عن البروتينولكن الـ
+
+480
+00:34:43,070 --> 00:34:45,070
+hypermethylation بتصير على الـ stone و لما أقول
+
+481
+00:34:45,070 --> 00:34:48,010
+hypermethylation يعني زيادة في عملية الـ
+
+482
+00:34:48,010 --> 00:34:50,790
+methylation شو هي الـ methylation؟ الـ methylation
+
+483
+00:34:50,790 --> 00:34:54,810
+هي عبارة عن عملية يتم فيها إضافة مجموعة methyl
+
+484
+00:34:54,810 --> 00:34:59,910
+group CH3 على الـ cytosine طب على كل الـ cytosine؟
+
+485
+00:34:59,910 --> 00:35:03,550
+لأ على الـ cytosine التي تتبعها جوانين فقط لغاية
+
+486
+00:35:03,550 --> 00:35:07,250
+طبعا لما نصير hypermethylation على الـ stoneIn
+
+487
+00:35:07,250 --> 00:35:10,650
+chromatin بعمل indication specific site where DNA
+
+488
+00:35:10,650 --> 00:35:14,650
+strand should be break and are later repaired
+
+489
+00:35:14,650 --> 00:35:16,910
+after crossing over لما يصير في هندي
+
+490
+00:35:16,910 --> 00:35:20,070
+hypermethylation بيصير relaxation للstone
+
+491
+00:35:20,070 --> 00:35:24,150
+relaxation للstone بيسمح لبعض الإنزيمات تدخل و
+
+492
+00:35:24,150 --> 00:35:27,430
+تقطع مناطق معينة هذا المناطق لازم يصير فيها
+
+493
+00:35:27,430 --> 00:35:31,630
+crossing over بعد كده بيصير لها repairing في
+
+494
+00:35:31,630 --> 00:35:35,150
+بروتين آخر بيساعد في عملية ال crossing over بنسميه
+
+495
+00:35:35,290 --> 00:35:39,350
+Condensin Protein أو Condensed Protein هذا مهم
+
+496
+00:35:39,350 --> 00:35:44,850
+جدًا للبروتين لأنه يعمل عملية مهمة جدًا في عمل
+
+497
+00:35:44,850 --> 00:35:49,450
+Condensation للكرومزومة ناخد ملاحظة مهمة جدًا أن
+
+498
+00:35:49,450 --> 00:35:53,270
+الكرومزوم في الأصل المادة الوراثية الموجودة بداخله
+
+499
+00:35:53,270 --> 00:35:57,190
+و هي الكروماتين لازم تكون Closed عشان تكون Closed
+
+500
+00:35:57,190 --> 00:36:01,170
+لازم تصير Condensed لأنها لما تصير Condensed هذا
+
+501
+00:36:01,170 --> 00:36:06,000
+يمنعها من أي ضرر ممكن يواجههاأي أنزين ممكن يشتغل
+
+502
+00:36:06,000 --> 00:36:09,820
+عليها طب علشان يصير ال crossing over لازم يصير في
+
+503
+00:36:09,820 --> 00:36:12,760
+عندى decondensation لهذا الكروماتين، يعني
+
+504
+00:36:12,760 --> 00:36:16,180
+relaxation واللي بيعمل ال relaxation هي عبارة عن
+
+505
+00:36:16,180 --> 00:36:19,380
+الـ hypermethylation لذلك، البروتين الـ Condensed
+
+506
+00:36:19,380 --> 00:36:22,800
+يلعب رولة مهمة جدًا في الcrossing over من
+
+507
+00:36:22,800 --> 00:36:26,740
+الكرومزوم اللي محتاجه لكلا الميوتك والميتوتك
+
+508
+00:36:26,740 --> 00:36:32,040
+للإكمال بدون البروتين الـ Condensed ما فيه ميتوتك
+
+509
+00:36:32,040 --> 00:36:36,060
+division وما فيه ميوتك divisionالـ Second Meiotic
+
+510
+00:36:36,060 --> 00:36:43,160
+Division أو انقسام الميوز التاني هو انقسام المنصف
+
+511
+00:36:43,160 --> 00:36:46,980
+وفي الغالب .. في الغالب انقسام الميوز التاني هو
+
+512
+00:36:46,980 --> 00:36:53,040
+عبارة عن انقسام ميتوزي ولكن لا يُسبق بطور تمهيدي
+
+513
+00:36:53,040 --> 00:36:58,470
+يؤدي إلى زيادة عدد الكرموزوماتلأن أي انقسام مثل
+
+514
+00:36:58,470 --> 00:37:04,130
+انقسام الميتوزي يمر بالـ Prophase الـ Metaphase
+
+515
+00:37:04,130 --> 00:37:08,770
+الـ Anaphase الـ Telophase هو يسبقه انقسام تمهيدي
+
+516
+00:37:08,770 --> 00:37:13,790
+انقسام تمهيدي أو عفوا طور تمهيدي بتمثيل تضاعف
+
+517
+00:37:13,790 --> 00:37:18,010
+المادة الوراثية تضاعف المادة الوراثية فبالتالي
+
+518
+00:37:18,010 --> 00:37:22,950
+انقسام الميوزي الثاني هو عبارة عن انقسام ميتوزي
+
+519
+00:37:22,950 --> 00:37:28,480
+ولكن لا يسبقه طورا تمهيديالتضعف المادة الوراثية
+
+520
+00:37:28,480 --> 00:37:32,060
+عشان كده بتدخل اتنين and تطلع two cell كل واحدة
+
+521
+00:37:32,060 --> 00:37:38,500
+منهم one and فسمّاه انقسام منصف صورة بتوضح لي
+
+522
+00:37:38,500 --> 00:37:41,420
+الكلام اللي أنا حكيته على البوايضة الصورة ممكن
+
+523
+00:37:41,420 --> 00:37:45,220
+تلاقيها معقدة ولكن خلّينا ناخدها step by step تحت
+
+524
+00:37:45,220 --> 00:37:49,420
+عنوان the major event of human oogenesis and
+
+525
+00:37:49,420 --> 00:37:53,900
+follicular development هي عمر السيدة عمر السيدة
+
+526
+00:37:53,900 --> 00:38:00,380
+يقسم كتاليفترة أو العمر الجنيني ما قبل الولادة حتى
+
+527
+00:38:00,380 --> 00:38:05,300
+الولادة نبدأ من اليسار بعد الولادة و بعد الولودة
+
+528
+00:38:05,300 --> 00:38:09,400
+هذه ثلاث أحداث ايش بيصير فيها؟ طبعا لو انا طلعت
+
+529
+00:38:09,400 --> 00:38:14,840
+على الصورة صورة عبارة عن بويضة سموها بهذا الشكل في
+
+530
+00:38:14,840 --> 00:38:18,320
+ما قبل الميلاد او عفوا الطور الجنيني اللي بتسميه
+
+531
+00:38:18,320 --> 00:38:23,040
+fetal period no follicles مافي follicles التكونت
+
+532
+00:38:24,060 --> 00:38:29,840
+الـ Follicle هي عبارة عن بويضات موجودة داخل خلية
+
+533
+00:38:29,840 --> 00:38:33,340
+محفظة، بسميها لكل الـ Structure Follicle وهذه ما
+
+534
+00:38:33,340 --> 00:38:37,080
+بتكون إلا في وجود الرحم وعفوا، وجود المبيض، اللذي
+
+535
+00:38:37,080 --> 00:38:39,500
+يعتبر جزء من الجهاز التناثوري الـ Reproductive
+
+536
+00:38:39,500 --> 00:38:43,440
+System طبعا الـ Fetal Period لسه ما فيه Over اتكون
+
+537
+00:38:43,440 --> 00:38:46,260
+لأن الـ Primordial Germ Cell لسه خارج منطقة
+
+538
+00:38:46,260 --> 00:38:52,640
+الكونية فما فيه No Follicle جبل الميلاد تكون الـ
+
+539
+00:38:52,640 --> 00:38:55,500
+Follicle بدأت تتكونو ال primordial germ cell اللي
+
+540
+00:38:55,500 --> 00:39:00,560
+اتكونت بعد الميلاد بسمي ال primordial germ cell أو
+
+541
+00:39:00,560 --> 00:39:03,900
+ال primordial follicle إلى primar follicle بعد
+
+542
+00:39:03,900 --> 00:39:07,060
+البلو بسمي ال primar follicle secondary follicle
+
+543
+00:39:07,060 --> 00:39:11,580
+بعدين بسميها tertiary بعدين بصير ovulated oocyte
+
+544
+00:39:11,580 --> 00:39:15,120
+بعدين ال fertilization oocyte انصار fertilization
+
+545
+00:39:15,120 --> 00:39:19,740
+طب إيش الأحداث اللي بتصير؟ في ناس بيسميها أو علماء
+
+546
+00:39:19,740 --> 00:39:24,080
+بيسموها أو مدارس بيسموها تسمية أخرىفي منطقة الـ
+
+547
+00:39:24,080 --> 00:39:28,160
+Fetal Primordial بيسموها Ogonium حكينا إيش هي الـ
+
+548
+00:39:28,160 --> 00:39:32,240
+Ogonium هي عبارة عن Primordial جنب سلخ خضعت
+
+549
+00:39:32,240 --> 00:39:38,280
+لانقسام ميتوزي متكرر وصلت لسبعة ملوى بعد كده جاب
+
+550
+00:39:38,280 --> 00:39:44,080
+للميلاد حتى الميلاد بيسميها Primary Oocyte طبعا
+
+551
+00:39:44,080 --> 00:39:46,620
+الأحداث اللي بتصير ما بين ال Ogonium و ال Primary
+
+552
+00:39:46,620 --> 00:39:51,800
+Oocyte هي انقسامات ميتوزية علشان كده السيدة أو
+
+553
+00:39:51,800 --> 00:39:58,040
+الأنثىعندما تولد يكون المبيض يحتوي على خلايا تقدر
+
+554
+00:39:58,040 --> 00:40:02,040
+بعدد كبير ملايين الخلايا هنعرف قداش العدد بالضبط
+
+555
+00:40:02,040 --> 00:40:09,060
+تسمى Primary Oocyte طالما هو عبارة عن جنين بسميها
+
+556
+00:40:09,060 --> 00:40:14,500
+Ogonium أول ما يصير مولود بابي حي بسميها Primary
+
+557
+00:40:14,500 --> 00:40:19,380
+Oocyte طبعا ال Primary Oocyte بتخضع لانقسام ميوزي
+
+558
+00:40:20,300 --> 00:40:24,400
+وبتظلها حتى بعد الميلاد على شكل الـ primary oocyte
+
+559
+00:40:24,400 --> 00:40:29,360
+بعد الميلاد بتصير عملية arrested استقرار وإيقاف
+
+560
+00:40:29,360 --> 00:40:34,660
+للانقسام الميتوزي في طور معين وهو عبارة عن الـ
+
+561
+00:40:34,660 --> 00:40:41,180
+diprotin stage الخاص بالانقسام الميتوزي إذا وصلت
+
+562
+00:40:41,180 --> 00:40:46,400
+الأنثى إلى سن البلوغ 8، 9، 10، 11، 12، 13 whatever
+
+563
+00:40:47,310 --> 00:40:55,390
+الـ Primary Oocyte تبقى Primary Oocyte وتستكمل
+
+564
+00:40:55,390 --> 00:40:59,050
+انقسام الميوزي الأول لأنه صار في عندي إيقاف
+
+565
+00:40:59,050 --> 00:41:03,490
+لانقسام الميوزي الأول في مرحلة بنتسميها الـ
+
+566
+00:41:03,490 --> 00:41:08,470
+diprotin stage تستكمل انقسام الميوزي الأول بمجرد
+
+567
+00:41:08,470 --> 00:41:13,650
+استكمالها انقسام الميوزي الأول حطيقيني خلية تسمى
+
+568
+00:41:13,650 --> 00:41:20,490
+secondary oocyteوخلية تسمى polar body أيش الفرق
+
+569
+00:41:20,490 --> 00:41:23,010
+بين ال secondary oocyte و ال polar body تعالى
+
+570
+00:41:23,010 --> 00:41:26,950
+ناخدها من الأول ال Ogonia بيقول فيها عندها خلية
+
+571
+00:41:26,950 --> 00:41:32,270
+تحتوى على two chromosome two C نين S two S يعني
+
+572
+00:41:32,270 --> 00:41:36,370
+two chromosomeالـ Primary Oocyte لأنها اتخضعت
+
+573
+00:41:36,370 --> 00:41:40,210
+لانقسام ميتوزي يحدث فيه تضاعف لعدد الكرموزومات
+
+574
+00:41:40,210 --> 00:41:45,070
+وتضاعف الخلايا فاعطاني Primary Oocyte تحتوي على 4S
+
+575
+00:41:45,070 --> 00:41:50,450
+يعني أربع كرموزومات تستمر على شكل Primary Oocyte
+
+576
+00:41:50,450 --> 00:41:54,030
+Primary Oocyte ومجرد ال Primary Oocyte بعد ما
+
+577
+00:41:54,030 --> 00:41:57,370
+اتوجفت في الـ Diploting Stage الخاص بالانقسام
+
+578
+00:41:57,370 --> 00:42:01,610
+الميتوزي الأول معناه هي ما كمل انقسام الميتوزي
+
+579
+00:42:01,610 --> 00:42:06,380
+الأولبمجرد ما تكمل انقسام الـ mitosis الأول و هو
+
+580
+00:42:06,380 --> 00:42:11,720
+الذي يحدث بمجرد وصول السيدة إلى سن الرشد الخلايا
+
+581
+00:42:11,720 --> 00:42:16,800
+اللي بتكون 4C تتحول إلى خليتين، كل خلية فيها اتنين
+
+582
+00:42:16,800 --> 00:42:21,080
+أس الاتنين أس التانية وين راحت؟ تحولت إلى polar
+
+583
+00:42:21,080 --> 00:42:24,960
+body يعني في عندي خلية هي عبارة عن ال primary
+
+584
+00:42:24,960 --> 00:42:28,490
+oocyteكملت الإنقسام اللي تحتوي على الاربعة
+
+585
+00:42:28,490 --> 00:42:33,750
+كرموزومات قملت الإنقسام الميتوزي الأول فعطتني خلية
+
+586
+00:42:33,750 --> 00:42:38,290
+فيها 2S وخلية فيها 2S الخلية الأولى فيها 2S سميتها
+
+587
+00:42:38,290 --> 00:42:42,290
+secondary oocyte و الخلية التانية فيها 2S سميتها
+
+588
+00:42:42,290 --> 00:42:47,110
+polar body why؟ ليش أنا سميتها polar body؟ لأنها
+
+589
+00:42:47,110 --> 00:42:51,030
+عبارة عن خليةتحتوي على 2 كرومزومات، 2 من
+
+590
+00:42:51,030 --> 00:42:55,290
+الكرومزومات ولكن كمية الهضيات وكمية الـ cytoplasm
+
+591
+00:42:55,290 --> 00:43:00,110
+اللي موجودة فيها لا تكفي أو لا تكفيها لكي ترتقي
+
+592
+00:43:00,110 --> 00:43:04,350
+إلى أن تصبح بويضة نادجة فبسميها polar body هل تخضع
+
+593
+00:43:04,350 --> 00:43:06,890
+لل fertilization؟ ليس لها علاقة بال fertilization
+
+594
+00:43:06,890 --> 00:43:11,610
+هل تنقسم؟ بعض المدارس بيقولك تنقسم ولكن لا ترتقي
+
+595
+00:43:11,610 --> 00:43:15,450
+إلى درجة secondary oocyte لكي تكمل عملية النقسام
+
+596
+00:43:15,450 --> 00:43:20,650
+ونحصل على بويضة نادجةالـ secondary oocyte بعد
+
+597
+00:43:20,650 --> 00:43:25,470
+البلوغ بيصير اللي هي عملية ovulation على شكل
+
+598
+00:43:25,470 --> 00:43:28,890
+secondary oocyte طب السؤال ال secondary oocyte
+
+599
+00:43:28,890 --> 00:43:32,530
+فيها اتنين كروموزوم و لو لقحت هتاخد كمان كروموزوم
+
+600
+00:43:32,530 --> 00:43:35,690
+من الذكر ال spirit هيصير فيه عند تلاتة كروموزوم
+
+601
+00:43:35,690 --> 00:43:39,950
+يعني عدد الكروموزومات لازم تكون في الطبيعة اتنين
+
+602
+00:43:39,950 --> 00:43:43,150
+فإذا حصلت على تلاتة فلا تصلح لعملية ال
+
+603
+00:43:43,150 --> 00:43:48,580
+fertilization البويضة إذا صارها ovulationعلى شكل
+
+604
+00:43:48,580 --> 00:43:56,720
+secondary oocyte وتحتوى على 2 كروموزوم تكون صالحة
+
+605
+00:43:56,720 --> 00:44:01,400
+لل fertilization ولا تستكمل عملية الانقسام الميوزي
+
+606
+00:44:01,400 --> 00:44:05,800
+التالي إلا بعد عملية ال fertilization بمجرد ما
+
+607
+00:44:05,800 --> 00:44:09,660
+يصير fertilization وهذا اللي بنسميها secondary
+
+608
+00:44:09,660 --> 00:44:13,660
+oocyte plus polar body بتصيرها arrested في مرحلة
+
+609
+00:44:13,660 --> 00:44:17,760
+الmetaphase 2 إيه شعر مرحلة الmetaphase 2؟يعني الـ
+
+610
+00:44:17,760 --> 00:44:21,200
+metaphase الخاص للانقسام الميوزي التاني فهل في
+
+611
+00:44:21,200 --> 00:44:24,260
+انقسام ميوزي تاني؟ أكيد لأن احنا حكينا انقسام
+
+612
+00:44:24,260 --> 00:44:27,340
+الميوزي هو عبارة عن ميوزي أول وميوزي تاني الميوزي
+
+613
+00:44:27,340 --> 00:44:30,440
+التاني يشبه انقسام الميتوزي ولكن لا يسبق وتضاعف
+
+614
+00:44:30,440 --> 00:44:33,520
+المادة الوراق فيها بمجرد ما يصير fertilization
+
+615
+00:44:33,520 --> 00:44:38,180
+ودخول ال sperm ال sperm بعمل activation للبويضة
+
+616
+00:44:38,180 --> 00:44:43,120
+اللي في شكل secondary oocyte علشان تكمل انقسام
+
+617
+00:44:43,120 --> 00:44:47,080
+الميوزي تكمل انقسام الميوزي كيف؟هتفصل الـ two
+
+618
+00:44:47,080 --> 00:44:51,660
+chromosome واحد هيطلع بخلية تسمى secondary polar
+
+619
+00:44:51,660 --> 00:44:56,520
+body والتاني هيبقى داخل ال oocyte عشان يندمج مع ال
+
+620
+00:44:56,520 --> 00:44:59,980
+chromosome اللي جاي من ال sperm ويحصل لي على خلية
+
+621
+00:44:59,980 --> 00:45:05,700
+تحتوي على two chromosome بسميها fertilized oocyte
+
+622
+00:45:05,700 --> 00:45:11,620
+يعني المحصلة النهائية هي عبارة عن mature oocyte
+
+623
+00:45:11,620 --> 00:45:18,510
+تحتوي plus one polar body أوfertilized oocyte plus
+
+624
+00:45:18,510 --> 00:45:24,050
+two polar body خلّيني أشوف الفيديو اللي بتكلم عن
+
+625
+00:45:24,050 --> 00:45:29,370
+هذه العملية طبعا
+
+626
+00:45:29,370 --> 00:45:33,650
+هذا الفيديو بتكلم كيف بتصير عملية ال fertilization
+
+627
+00:45:33,650 --> 00:45:41,150
+وعملية ال oogenesis طبعا هذا عندي هذه منطقة ال
+
+628
+00:45:41,150 --> 00:45:43,830
+cervical هذه منطقة الرحم هذه منطقة الفلوبيا
+
+629
+00:45:43,830 --> 00:45:48,420
+الكيوبا هذه منطقة ال ovaryفي منطقة الـ ovary في
+
+630
+00:45:48,420 --> 00:45:57,020
+عند الـ fully kill بتكون مصفوفة على طول ال ovary
+
+631
+00:45:57,020 --> 00:46:00,340
+طبعا هذه المراحل اللي بيمر فيها من اليمين لليسار
+
+632
+00:46:00,340 --> 00:46:05,420
+بتكون primordial
+
+633
+00:46:05,420 --> 00:46:11,400
+germ cell وخلافه او immature oocyte او first
+
+634
+00:46:11,400 --> 00:46:15,940
+oocyte او primary oocyte مش المسمى ولكن اكتر
+
+635
+00:46:16,240 --> 00:46:20,200
+المسميات انتشارا هي ال primary oocyte او ال
+
+636
+00:46:20,200 --> 00:46:24,060
+ogonium بعدين تديني primary لان حكينا ogonium
+
+637
+00:46:24,060 --> 00:46:32,380
+primary secondary خلينا نشوف ايش العملية تصير فيها
+
+638
+00:46:32,380 --> 00:46:39,660
+هذا
+
+639
+00:46:39,660 --> 00:46:45,780
+بيعمل zoom على البوادة هي ال ogonium عمل zoom لها
+
+640
+00:46:46,680 --> 00:46:52,140
+البويضة بدأت تتطور دخلت الانقسام الميتوزي علشان
+
+641
+00:46:52,140 --> 00:47:00,060
+تتضاعف تضاعفت البويضة اعطتلي تنتين مثلا او جونيام
+
+642
+00:47:00,060 --> 00:47:05,400
+هتدخل انقسام نمت هتدخل انقسام الميوزي الأول فيه
+
+643
+00:47:05,400 --> 00:47:10,840
+عنده two chromosome وعشانها بويضة لازم تاخد
+
+644
+00:47:10,840 --> 00:47:13,680
+كرموزوم من الأم و كرموزوم من الأب لذا هذا ال two
+
+645
+00:47:13,680 --> 00:47:17,040
+chromosome لازم تفصلنحصل على وان كرموزوم والتاني
+
+646
+00:47:17,040 --> 00:47:21,980
+جيميل الأب طيب هتدخل انقسام ميوزي أول ومجرد ايه
+
+647
+00:47:21,980 --> 00:47:26,900
+primary oocyte primary oocyte دخلت انقسام ميوزي
+
+648
+00:47:26,900 --> 00:47:31,900
+أول هيتخلص من هذا الكرموزوم على شكل polar body
+
+649
+00:47:31,900 --> 00:47:37,580
+وعندي هذا الكرموزوم طبعا خد بالك كرموزوم هو عبارة
+
+650
+00:47:37,580 --> 00:47:41,140
+عن two sister chromatid فلازم تخلص من one sister
+
+651
+00:47:41,140 --> 00:47:45,070
+chromatid علشان ناخد التاني من الأبفبالتالي بحصل
+
+652
+00:47:45,070 --> 00:47:49,450
+على زوج من الكروموزون خلص منه او chromated
+
+653
+00:47:49,450 --> 00:47:52,590
+whatever المسمى مش عندهم كتير عن المسمى حاليا لان
+
+654
+00:47:52,590 --> 00:47:56,670
+هموضحها قدام بالتحصيل ان شاء الله هداني polar body
+
+655
+00:47:56,670 --> 00:48:02,870
+و secondary oocyte دخلت في انقسام الميوزي التاني
+
+656
+00:48:02,870 --> 00:48:07,410
+كملته طبعا هداني secondary polar body بس علشان
+
+657
+00:48:07,410 --> 00:48:12,650
+يكون الموضوع واضح جدا ان انقسام الميتوزي الثاني لا
+
+658
+00:48:13,050 --> 00:48:17,730
+يحدث و لا يتم إلا بمجرد حدوث ال fertilization
+
+659
+00:48:17,730 --> 00:48:22,030
+طالما البوايبة ماصرلش fertilization تبقى secondary
+
+660
+00:48:22,030 --> 00:48:27,410
+oocyte بدون second polar body لكن هذا animation ما
+
+661
+00:48:27,410 --> 00:48:33,110
+بقدر أوضحها فيها في ال animation هذا بالفعلطبعا
+
+662
+00:48:33,110 --> 00:48:36,630
+هنا بيقول الفولار بادي قد ينقسم صحيح قد ينقسم ولكن
+
+663
+00:48:36,630 --> 00:48:39,630
+لا يرتقي الى بوادة تلقح عشان كده بيصيرله
+
+664
+00:48:39,630 --> 00:48:44,110
+degradation عشان كده بيصيرله degradation فيما بعد
+
+665
+00:48:44,110 --> 00:48:48,770
+هذه
+
+666
+00:48:48,770 --> 00:48:53,270
+الفولار بادي بيصيرها عملية تدمير و removing و
+
+667
+00:48:53,270 --> 00:48:57,890
+بعدين بيصيرها the ghost انا سايرالايسز داخل الخلية
+
+668
+00:48:57,890 --> 00:49:03,990
+حصلت على employ egg طبعاجاهزة للتلقيح بس ده مش
+
+669
+00:49:03,990 --> 00:49:07,710
+دقيق ال animation كتير هنشوف animation تاني أكثر
+
+670
+00:49:07,710 --> 00:49:12,170
+درجة ان شاء الله هذا بالنسبة إلى تصنيع ال oocyte
+
+671
+00:49:12,170 --> 00:49:15,910
+ال primary وال secondary ال first polar body وال
+
+672
+00:49:15,910 --> 00:49:20,210
+second polar body كيف يتم عملية التنصيب هنكتفي
+
+673
+00:49:20,210 --> 00:49:24,610
+بهذا القدر في هذه المحاضرة على أن نستكمل في
+
+674
+00:49:24,610 --> 00:49:28,870
+المحاضرة القادمة ان شاء الله توم توم في حفظ الله
+
+675
+00:49:28,870 --> 00:49:29,910
+وارعة
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/diNdtthu9cM_raw.json b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/diNdtthu9cM_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..6b402f10d28c6cfb701bacd790e8eabb68694358
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/diNdtthu9cM_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2743, "start": 1.35, "end": 27.43, "text": "بسم الله الرحمن الرحيم والصلاة والسلام على أشرف المرسلين سيدنا محمد الصادق الأمين أما بعد توقفنا في المحاضرة السابقة عند ال ovulatory phase as one of menstrual cycle stage or phase وقلنا أن هذا الطور يستهلك ما يقارب من 32 ساعة إلى 16 ساعة من خلال أيام الدورة الشهرية الكاملة التي تتمثل في 28 يوم", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 16070, 9381, 15040, 3660, 16070, 3794, 37440, 15844, 5551, 8592, 28480, 9673, 2288, 3794, 1211, 9957, 8608, 25708, 8315, 3714, 35571, 3215, 31767, 18513, 4587, 16247, 2304, 9957, 5551, 15042, 39182, 6055, 30543, 5172, 8315, 8978, 9673, 5016, 46958, 25720, 21136, 16758, 28671, 43242, 2423, 14187, 425, 4745, 5574, 382, 472, 295, 38827, 304, 6586, 3233, 420, 5574, 4032, 4587, 1211, 8315, 14739, 23758, 41950, 13063, 7251, 14851, 3224, 23275, 19446, 7251, 4587, 9640, 3555, 9154, 8858, 8608, 995, 27884, 30731, 3165, 8608, 995, 27884, 9154, 16490, 1211, 6027, 36632, 10943, 32748, 13063, 3660, 25124, 3224, 2288, 10632, 33251, 10943, 37977, 38392, 6055, 39237, 12984, 1211, 8978, 7562, 7251, 20498], "avg_logprob": -0.13593750298023224, "compression_ratio": 1.694736842105263, "no_speech_prob": 4.172325134277344e-07, "words": [{"start": 1.35, "end": 1.67, "word": "بسم", "probability": 0.84375}, {"start": 1.67, "end": 1.97, "word": " الله", "probability": 0.9580078125}, {"start": 1.97, "end": 2.49, "word": " الرحمن", "probability": 0.9734700520833334}, {"start": 2.49, "end": 2.97, "word": " الرحيم", "probability": 0.9934895833333334}, {"start": 2.97, "end": 3.51, "word": " والصلاة", "probability": 0.83941650390625}, {"start": 3.51, "end": 4.01, "word": " والسلام", "probability": 0.9500325520833334}, {"start": 4.01, "end": 4.29, "word": " على", "probability": 0.55908203125}, {"start": 4.29, "end": 4.75, "word": " أشرف", "probability": 0.9864908854166666}, {"start": 4.75, "end": 5.43, "word": " المرسلين", "probability": 0.98603515625}, 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LH الـ LH يستطيله ريسبتور تقدر بـ 20 ألف ريسبتور موجودة على سطح الـ leading cells الموجودة في الـ testes فمجرد إفراز الـ LH من خلال الـ anterior loop للبطيوريجلان ينقل عبر الدم إلى الـ leading cell الموجودة في الـ testes الخاصة بالمياه هذا الـ l-autolizing hormone", "tokens": [6027, 39184, 47403, 345, 310, 1513, 259, 12, 265, 306, 3349, 24211, 13672, 1829, 4724, 1829, 10721, 49115, 15844, 2423, 39184, 22272, 6367, 24976, 3555, 9566, 1829, 13063, 1829, 7435, 1211, 7649, 6156, 21292, 5172, 2288, 11622, 2423, 39184, 479, 17308, 16070, 39184, 441, 39, 2423, 39184, 441, 39, 7251, 14851, 9566, 26895, 3224, 12602, 1829, 35457, 2655, 13063, 6055, 28543, 2288, 4724, 39184, 945, 5551, 46538, 12602, 1829, 35457, 2655, 13063, 3714, 29245, 23328, 3660, 15844, 8608, 9566, 5016, 2423, 39184, 5775, 5438, 9673, 29245, 23328, 3660, 8978, 2423, 39184, 1500, 279, 6156, 2304, 7435, 2288, 3215, 11933, 5172, 2288, 31377, 2423, 39184, 441, 39, 9154, 16490, 1211, 6027, 2423, 39184, 22272, 6367, 24976, 3555, 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"probability": 0.988671875}, {"start": 1826.88, "end": 1827.44, "word": " المطلوبة", "probability": 0.95908203125}, {"start": 1827.44, "end": 1827.8, "word": " منها", "probability": 0.99267578125}, {"start": 1827.8, "end": 1828.56, "word": " ويكون", "probability": 0.7703450520833334}, {"start": 1828.56, "end": 1829.08, "word": " أفرزة", "probability": 0.91591796875}, {"start": 1829.08, "end": 1829.5, "word": " الكمية", "probability": 0.7473958333333334}, {"start": 1829.5, "end": 1830.1, "word": " المطلوبة", "probability": 0.9796875}, {"start": 1830.1, "end": 1830.26, "word": " من", "probability": 0.9912109375}, {"start": 1830.26, "end": 1831.0, "word": " الهرمونات", "probability": 0.9421735491071429}, {"start": 1831.0, "end": 1831.84, "word": " المسؤولة", "probability": 0.893359375}, {"start": 1831.84, "end": 1832.0, "word": " عن", "probability": 0.97900390625}, {"start": 1832.0, "end": 1832.4, "word": " تصنيع", "probability": 0.9703369140625}, {"start": 1832.4, "end": 1832.56, "word": " الـ", "probability": 0.817138671875}, {"start": 1832.56, "end": 1833.4, "word": " spermatozoa", "probability": 0.722259521484375}, {"start": 1833.4, "end": 1834.24, "word": " تعمل", "probability": 0.9241536458333334}, {"start": 1834.24, "end": 1834.46, "word": " على", "probability": 0.92431640625}, {"start": 1834.46, "end": 1834.92, "word": " إفراز", "probability": 0.9615478515625}, {"start": 1834.92, "end": 1835.3, "word": " هرمون", "probability": 0.876708984375}, {"start": 1835.3, "end": 1835.72, "word": " اسمه", "probability": 0.9488932291666666}, {"start": 1835.72, "end": 1835.86, "word": " الـ", "probability": 0.68505859375}, {"start": 1835.86, "end": 1836.42, "word": " Estrogen", "probability": 0.6083984375}, {"start": 1836.42, "end": 1837.08, "word": " leading", "probability": 0.74951171875}, {"start": 1837.08, "end": 1837.4, "word": " cell", "probability": 0.9111328125}, {"start": 1837.4, "end": 1837.94, "word": " stimulating", "probability": 0.7763671875}, {"start": 1837.94, "end": 1838.58, "word": " factor", "probability": 0.83984375}, {"start": 1838.58, "end": 1839.28, "word": " هذا", "probability": 0.525390625}, {"start": 1839.28, "end": 1839.4, "word": " الـ", "probability": 0.5867919921875}, {"start": 1839.4, "end": 1839.92, "word": " Estrogen", "probability": 0.88037109375}, {"start": 1839.92, "end": 1841.08, "word": " يعمل", "probability": 0.9532877604166666}, {"start": 1841.08, "end": 1841.8, "word": " أيضًا", "probability": 0.893798828125}, {"start": 1841.8, "end": 1842.3, "word": " على", "probability": 0.94970703125}, {"start": 1842.3, "end": 1843.46, "word": " تحفيز", "probability": 0.78961181640625}], "temperature": 1.0}, {"id": 71, "seek": 187035, "start": 1844.95, "end": 1870.35, "text": "الـ leading cell لإستمرار إفراز الـ testosterone عند الحاجة أو يفبطها عند انتهاء الوظيفة المطلوبة منها إذا في عندي two arrows red for stimulation و purple for inhibitor نفس الهرمون ممكن يعمل inhibition و يعمل stimulation أو ممكن هرمون آخر يفرز من نفس ال cells من أجل عمل inhibition للـhypothalamus و الانتيرويوب أو", "tokens": [6027, 39184, 5775, 2815, 5296, 28814, 14851, 29973, 9640, 11933, 5172, 2288, 31377, 2423, 39184, 1500, 7096, 546, 43242, 21542, 26108, 3660, 34051, 7251, 5172, 3555, 9566, 11296, 43242, 16472, 47395, 16606, 2423, 2407, 19913, 33911, 3660, 9673, 9566, 1211, 37746, 3660, 9154, 11296, 11933, 15730, 8978, 18871, 16254, 732, 19669, 2182, 337, 37405, 4032, 9656, 337, 20406, 3029, 8717, 36178, 2423, 3224, 2288, 2304, 11536, 3714, 43020, 7251, 25957, 1211, 20406, 849, 4032, 7251, 25957, 1211, 37405, 34051, 3714, 43020, 8032, 2288, 2304, 11536, 19753, 34740, 7251, 5172, 2288, 11622, 9154, 8717, 36178, 2423, 5438, 9154, 5551, 7435, 1211, 6225, 42213, 20406, 849, 24976, 39184, 3495, 79, 900, 23819, 301, 4032, 2423, 7649, 31371, 32887, 1829, 37746, 34051], "avg_logprob": -0.24492187425494194, "compression_ratio": 1.7330827067669172, "no_speech_prob": 0.0, "words": [{"start": 1844.95, "end": 1845.79, "word": "الـ", "probability": 0.516357421875}, {"start": 1845.79, "end": 1846.11, "word": " leading", "probability": 0.71142578125}, {"start": 1846.11, "end": 1846.43, "word": " cell", "probability": 0.90380859375}, {"start": 1846.43, "end": 1847.17, "word": " لإستمرار", "probability": 0.79404296875}, {"start": 1847.17, "end": 1847.49, "word": " إفراز", "probability": 0.934326171875}, {"start": 1847.49, "end": 1847.63, "word": " الـ", "probability": 0.80029296875}, {"start": 1847.63, "end": 1848.17, "word": " testosterone", "probability": 0.6783854166666666}, {"start": 1848.17, "end": 1848.37, "word": " عند", "probability": 0.95849609375}, {"start": 1848.37, "end": 1848.89, "word": " الحاجة", "probability": 0.9938151041666666}, {"start": 1848.89, "end": 1849.45, "word": " أو", "probability": 0.9599609375}, {"start": 1849.45, "end": 1850.23, "word": " يفبطها", "probability": 0.88515625}, {"start": 1850.23, "end": 1850.85, "word": " عند", "probability": 0.9892578125}, {"start": 1850.85, "end": 1851.51, "word": " انتهاء", "probability": 0.87255859375}, {"start": 1851.51, "end": 1852.31, "word": " الوظيفة", "probability": 0.98828125}, {"start": 1852.31, "end": 1853.15, "word": " المطلوبة", "probability": 0.9318359375}, {"start": 1853.15, "end": 1853.43, "word": " منها", "probability": 0.97607421875}, {"start": 1853.43, "end": 1853.83, "word": " إذا", "probability": 0.51824951171875}, {"start": 1853.83, "end": 1854.01, "word": " في", "probability": 0.301025390625}, {"start": 1854.01, "end": 1854.41, "word": " عندي", "probability": 0.751220703125}, {"start": 1854.41, "end": 1855.05, "word": " two", "probability": 0.62841796875}, {"start": 1855.05, "end": 1855.61, "word": " arrows", "probability": 0.89697265625}, {"start": 1855.61, "end": 1856.23, "word": " red", "probability": 0.38720703125}, {"start": 1856.23, "end": 1856.61, "word": " for", "probability": 0.90087890625}, {"start": 1856.61, "end": 1857.31, "word": " stimulation", "probability": 0.98291015625}, {"start": 1857.31, "end": 1857.65, "word": " و", "probability": 0.91845703125}, {"start": 1857.65, "end": 1857.91, "word": " purple", "probability": 0.484130859375}, {"start": 1857.91, "end": 1858.21, "word": " for", "probability": 0.95263671875}, {"start": 1858.21, "end": 1858.95, "word": " inhibitor", "probability": 0.874755859375}, {"start": 1858.95, "end": 1859.91, "word": " نفس", "probability": 0.98876953125}, {"start": 1859.91, "end": 1860.23, "word": " الهرمون", "probability": 0.808203125}, {"start": 1860.23, "end": 1860.51, "word": " ممكن", "probability": 0.91845703125}, {"start": 1860.51, "end": 1860.77, "word": " يعمل", "probability": 0.9386393229166666}, {"start": 1860.77, "end": 1861.19, "word": " inhibition", "probability": 0.86376953125}, {"start": 1861.19, "end": 1861.31, "word": " و", "probability": 0.93359375}, {"start": 1861.31, "end": 1861.47, "word": " يعمل", "probability": 0.778076171875}, {"start": 1861.47, "end": 1861.97, "word": " stimulation", "probability": 0.95703125}, {"start": 1861.97, "end": 1862.73, "word": " أو", "probability": 0.869140625}, {"start": 1862.73, "end": 1863.01, "word": " ممكن", "probability": 0.94189453125}, {"start": 1863.01, "end": 1863.43, "word": " هرمون", "probability": 0.96875}, {"start": 1863.43, "end": 1863.93, "word": " آخر", "probability": 0.76318359375}, {"start": 1863.93, "end": 1864.85, "word": " يفرز", "probability": 0.875244140625}, {"start": 1864.85, "end": 1865.27, "word": " من", "probability": 0.98974609375}, {"start": 1865.27, "end": 1865.53, "word": " نفس", "probability": 0.99658203125}, {"start": 1865.53, "end": 1865.69, "word": " ال", "probability": 0.9189453125}, {"start": 1865.69, "end": 1865.97, "word": " cells", "probability": 0.73095703125}, {"start": 1865.97, "end": 1866.39, "word": " من", "probability": 0.95654296875}, {"start": 1866.39, "end": 1866.75, "word": " أجل", "probability": 0.9889322916666666}, {"start": 1866.75, "end": 1867.37, "word": " عمل", "probability": 0.977294921875}, {"start": 1867.37, "end": 1868.09, "word": " inhibition", "probability": 0.828857421875}, {"start": 1868.09, "end": 1869.07, "word": " للـhypothalamus", "probability": 0.7131696428571429}, {"start": 1869.07, "end": 1869.25, "word": " و", "probability": 0.58740234375}, {"start": 1869.25, "end": 1870.05, "word": " الانتيرويوب", "probability": 0.5306396484375}, {"start": 1870.05, "end": 1870.35, "word": " أو", "probability": 0.82275390625}], "temperature": 1.0}, {"id": 72, "seek": 188428, "start": 1872.08, "end": 1884.28, "text": "بهذا القدر نقوم انتهينا من ال chapter الأول ان شاء الله على أمل أن نستكمل في المحاضرات القادمة بأم الله، دومتم في حفظ الله وريعاك", "tokens": [3555, 3224, 15730, 25062, 3215, 2288, 8717, 4587, 20498, 16472, 47395, 1829, 8315, 9154, 2423, 7187, 16247, 12610, 16472, 13412, 16606, 21984, 15844, 5551, 42213, 14739, 8717, 14851, 24793, 1211, 8978, 9673, 5016, 46958, 2288, 9307, 25062, 18513, 46007, 4724, 10721, 2304, 21984, 12399, 11778, 20498, 39237, 8978, 11331, 5172, 19913, 21984, 4032, 16572, 3615, 995, 4117], "avg_logprob": -0.24488146860024024, "compression_ratio": 1.4836601307189543, "no_speech_prob": 0.0, "words": [{"start": 1872.08, "end": 1872.54, "word": "بهذا", "probability": 0.8899739583333334}, {"start": 1872.54, "end": 1873.16, "word": " القدر", "probability": 0.9951171875}, {"start": 1873.16, "end": 1873.7, "word": " نقوم", "probability": 0.9503580729166666}, {"start": 1873.7, "end": 1874.56, "word": " انتهينا", "probability": 0.6833343505859375}, {"start": 1874.56, "end": 1874.76, "word": " من", "probability": 0.9775390625}, {"start": 1874.76, "end": 1874.9, "word": " ال", "probability": 0.50634765625}, {"start": 1874.9, "end": 1875.18, "word": " chapter", "probability": 0.84521484375}, {"start": 1875.18, "end": 1875.66, "word": " الأول", "probability": 0.91162109375}, {"start": 1875.66, "end": 1875.84, "word": " ان", "probability": 0.37646484375}, {"start": 1875.84, "end": 1876.12, "word": " شاء", "probability": 0.989990234375}, {"start": 1876.12, "end": 1876.36, "word": " الله", "probability": 0.943359375}, {"start": 1876.36, "end": 1877.4, "word": " على", "probability": 0.74560546875}, {"start": 1877.4, "end": 1877.74, "word": " أمل", "probability": 0.908203125}, {"start": 1877.74, "end": 1877.96, "word": " أن", "probability": 0.75439453125}, {"start": 1877.96, "end": 1878.56, "word": " نستكمل", "probability": 0.97314453125}, {"start": 1878.56, "end": 1878.72, "word": " في", "probability": 0.912109375}, {"start": 1878.72, "end": 1879.38, "word": " المحاضرات", "probability": 0.97568359375}, {"start": 1879.38, "end": 1880.12, "word": " القادمة", "probability": 0.99560546875}, {"start": 1880.12, "end": 1880.7, "word": " بأم", "probability": 0.7887369791666666}, {"start": 1880.7, "end": 1881.56, "word": " الله،", "probability": 0.34759521484375}, {"start": 1881.56, "end": 1882.02, "word": " دومتم", "probability": 0.6433919270833334}, {"start": 1882.02, "end": 1882.36, "word": " في", "probability": 0.93505859375}, {"start": 1882.36, "end": 1882.72, "word": " حفظ", "probability": 0.9982096354166666}, {"start": 1882.72, "end": 1883.06, "word": " الله", "probability": 0.92578125}, {"start": 1883.06, "end": 1884.28, "word": " وريعاك", "probability": 0.639697265625}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1927.442, "duration_after_vad": 1837.5149999999958}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/diNdtthu9cM_raw.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/diNdtthu9cM_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f65e4070e5a8f86d9de9c5632b58b253a3be9d7a
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/diNdtthu9cM_raw.srt
@@ -0,0 +1,1836 @@
+1
+00:00:01,350 --> 00:00:04,750
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:04,750 --> 00:00:09,470
+المرسلين سيدنا محمد الصادق الأمين أما بعد توقفنا
+
+3
+00:00:09,470 --> 00:00:13,510
+في المحاضرة السابقة عند ال ovulatory phase as one
+
+4
+00:00:13,510 --> 00:00:16,910
+of menstrual cycle stage or phase وقلنا أن هذا
+
+5
+00:00:16,910 --> 00:00:22,410
+الطور يستهلك ما يقارب من 32 ساعة إلى 16 ساعة من
+
+6
+00:00:22,410 --> 00:00:26,690
+خلال أيام الدورة الشهرية الكاملة التي تتمثل في 28
+
+7
+00:00:26,690 --> 00:00:32,290
+يومفي هذا الطور يتمثل خروج البويضة من المبيض تحت
+
+8
+00:00:32,290 --> 00:00:36,570
+مصطلح بيسمى الـ Opulation أي الطبويد وهذا الطبويد
+
+9
+00:00:36,570 --> 00:00:39,790
+يحدث بفعل هرمون يسمى الـ Lutralizing hormone حيث
+
+10
+00:00:39,790 --> 00:00:44,370
+عندما تصل لـ Graphian Follicle الحجم المطلوب الذي
+
+11
+00:00:44,370 --> 00:00:47,830
+يدل على وصوله إلى الـ Maturation Stage تبدأ بإفراز
+
+12
+00:00:47,830 --> 00:00:51,970
+كمية كبيرة جدا من الـ Estrogen هرمون هذا الـ
+
+13
+00:00:51,970 --> 00:00:55,610
+Estrogen هرمون يحفظ الـ Pituitary gland anterior
+
+14
+00:00:55,610 --> 00:01:00,460
+loop لإفراز Lutralizing hormoneالذي يعمل على تفجير
+
+15
+00:01:00,460 --> 00:01:06,620
+الفوليكل وخروج البوايدة البوايدة خرجت من الفوليكل
+
+16
+00:01:06,620 --> 00:01:09,340
+اللي سميتها Graphene Follicle والـ Graphene
+
+17
+00:01:09,340 --> 00:01:13,620
+Follicle في مباعد بتحول إلى الجسم الأصفر أو Corpus
+
+18
+00:01:13,620 --> 00:01:18,800
+Luteum الذي يلعب دورة مهمة جدا في عملية استمرار أو
+
+19
+00:01:18,800 --> 00:01:22,700
+تغذية الجسم بالـ Progesterone هرمون في بداية الحمل
+
+20
+00:01:22,700 --> 00:01:28,790
+وهو الذي يعمل على استقرار الحمل في أول أيامهطبعاً
+
+21
+00:01:28,790 --> 00:01:34,130
+في نهاية الـ Wave الخاصة بالـ LH تبدأ عملية
+
+22
+00:01:34,130 --> 00:01:41,370
+التبويض بالحدوث ما بين 10 إلى 12 ساعة يعني بعد الـ
+
+23
+00:01:41,370 --> 00:01:45,350
+Wave أو نهاية الـ LH Wave بعشر ساعات ممكن يصير
+
+24
+00:01:45,350 --> 00:01:49,550
+التبويض أو 12 ساعة ممكن يصير التبويض فبالتالي الـ
+
+25
+00:01:49,550 --> 00:01:52,930
+LH وظيفته فقط الـ ovulation ما له علاقة بالـ
+
+26
+00:01:52,930 --> 00:01:57,230
+maturation الذي لهدورة مهمة في عملية ال maturation
+
+27
+00:01:57,230 --> 00:02:03,770
+هو ال FSH هرمون ال FSH هرمون طبعا ال oocyte about
+
+28
+00:02:03,770 --> 00:02:09,530
+24 hours after this day the egg will be die or
+
+29
+00:02:09,530 --> 00:02:14,260
+dissolve if there is no fertilization okayطبعا
+
+30
+00:02:14,260 --> 00:02:18,380
+فترة حياة البويضة بعد تبويض 24 ساعة فقط لغير، يعني
+
+31
+00:02:18,380 --> 00:02:20,460
+يوم كامل، يعني خلال هذا اليوم لازم يصير
+
+32
+00:02:20,460 --> 00:02:24,440
+fertilization أو intercourses علشان يصير عنده
+
+33
+00:02:24,440 --> 00:02:28,420
+pregnancy، يصير عنده fetus مستقبلا إذا ما صار فيه
+
+34
+00:02:28,420 --> 00:02:31,360
+intercourses، يعني ما صار فيه fertilization،
+
+35
+00:02:31,360 --> 00:02:36,260
+البويضة بتموت و بتدوب و تخرج مع ال bleedingفي
+
+36
+00:02:36,260 --> 00:02:40,860
+مرحلة الـ menstrual phase fertilization is more
+
+37
+00:02:40,860 --> 00:02:44,280
+likely when sperm are present in the productive
+
+38
+00:02:44,280 --> 00:02:48,460
+tract before the egg is released أفضل حالات ال
+
+39
+00:02:48,460 --> 00:02:52,980
+fertilization تحدث و الأكثر حدوثا أن ال sperm يكون
+
+40
+00:02:52,980 --> 00:02:56,920
+موجود في ال fallopian tube قبل أيام الطبوية بيوم
+
+41
+00:02:56,920 --> 00:03:00,180
+أو بيومين لأن ال sperm بتميز أن ال half-life
+
+42
+00:03:00,180 --> 00:03:03,430
+الخاصة فيه تلت أيامبينما ال half-life تبعت ال
+
+43
+00:03:03,430 --> 00:03:06,650
+oocyte يوم واحد علشان أطمن أنه يحصل فيه pregnancy
+
+44
+00:03:06,650 --> 00:03:10,970
+و يحصل fertilization لازم يكون ال sperm في انتظار
+
+45
+00:03:10,970 --> 00:03:14,010
+البويضة يعني ال sperm يكون وصل في لوبيا التيوب
+
+46
+00:03:14,010 --> 00:03:18,950
+جابل البويضة ما يصير لها عملية ovulation وهذه أكثر
+
+47
+00:03:18,950 --> 00:03:23,590
+حالات ل pregnancy حدوثا طبعا ال egg released does
+
+48
+00:03:23,590 --> 00:03:27,130
+not alternate between the two ovarian and appear
+
+49
+00:03:27,130 --> 00:03:31,350
+to be randomبمعنى آخر أن ال over الأيمن و ال over
+
+50
+00:03:31,350 --> 00:03:36,130
+الأيسر كلاهما يعمل بشكل مستقل بمعنى آخر أن كلاهما
+
+51
+00:03:36,130 --> 00:03:40,510
+يستطيع إخراج بويضة في نفس الشهر مافي حاجة اسمها أن
+
+52
+00:03:40,510 --> 00:03:45,670
+المبيضين يتناوبوا في شهر مايو يشغل المبيض الأيمن
+
+53
+00:03:45,670 --> 00:03:49,710
+في شهر ستة يشغل الأيسر في شهر سبعة يرجع الأيمن في
+
+54
+00:03:49,710 --> 00:03:54,790
+شهر تمانية يرجع الأيسر مافي تناوب في العمل والدليل
+
+55
+00:03:54,790 --> 00:04:00,850
+أن في بعض الأحيان ممكن يصير في انديtwins أو triple
+
+56
+00:04:00,850 --> 00:04:04,970
+لأن المبيض أفرز بوايدتين وهذا المبيض أفرز بوايدة
+
+57
+00:04:04,970 --> 00:04:08,010
+أو أجد بوايدة من المبيض الأيمن و بوايدة من المبيض
+
+58
+00:04:08,010 --> 00:04:13,050
+الأيسر حالة أخرى تؤكد هذا الكلام بمعنى آخر إن
+
+59
+00:04:13,050 --> 00:04:17,150
+السيدة لو خضعت إلى عملية جراحية استقصلت أحد
+
+60
+00:04:17,150 --> 00:04:21,490
+المبيضين فالمبيض الأخر سوف يستمر كل شهر في إفراز
+
+61
+00:04:21,490 --> 00:04:27,890
+وانضاج بوايدة ما بنلاقي شهر أه وشهر لأ فالعملية
+
+62
+00:04:28,160 --> 00:04:32,660
+بتكون بشكل عشوائي مافي نوع من أنواع الترتيب الطور
+
+63
+00:04:32,660 --> 00:04:35,540
+الأخير من أطوار الدورة الشرية اللي بنسميه الـ UTL
+
+64
+00:04:35,540 --> 00:04:39,120
+phase أو حاجة بنسميها ال post-ovulatory phase
+
+65
+00:04:39,120 --> 00:04:45,720
+وبتاخد من 15 إلى 28 من أيام الدورة خلال الـ UTL
+
+66
+00:04:45,720 --> 00:04:48,760
+phase و اللي بيصير بعد ال rupture of the follicle
+
+67
+00:04:48,760 --> 00:04:51,480
+which causes releasing of the oocyte and forms a
+
+68
+00:04:51,480 --> 00:04:54,160
+structure called the corpus luteum يعني الفولكل
+
+69
+00:04:54,160 --> 00:04:58,630
+صارها rupture طلعت ال oocyteبعد ما تطلع الـ Oocyte
+
+70
+00:04:58,630 --> 00:05:03,690
+هذه الفولكية بتتحول إلى كوربوس اليوتيوم الذي يقوم
+
+71
+00:05:03,690 --> 00:05:06,810
+بتقليم و إزالة البروجسترون هذا الكوربوس اليوتيوم
+
+72
+00:05:06,810 --> 00:05:10,890
+مهم جدا في أول بداية الحمل بعد انحدث البروجسترون
+
+73
+00:05:10,890 --> 00:05:16,570
+أو في أول العملية أو في أول عملية الـ util phase
+
+74
+00:05:16,570 --> 00:05:20,130
+أول أطوار الـ util phase لأنه بيعمل على إنتاج كمية
+
+75
+00:05:20,130 --> 00:05:24,430
+كبيرة جدا من البروجسترون على أمل أن يحصل في أدي
+
+76
+00:05:24,430 --> 00:05:29,140
+البروجسترونالبروجسترون هل له وظيفة معينة؟ أكيد
+
+77
+00:05:29,140 --> 00:05:33,980
+البروجسترون بيعمل على تحفيز المبيض على تهييء
+
+78
+00:05:33,980 --> 00:05:38,000
+المبيض لعملية ال implantation من خلال تدعيم ال
+
+79
+00:05:38,000 --> 00:05:42,220
+endomaterium regeneration تدعيم بطانة الرحم caused
+
+80
+00:05:42,220 --> 00:05:46,220
+endomaterium to thick بيخلي بطانة الرحم أكثر سماكة
+
+81
+00:05:46,220 --> 00:05:50,880
+إذا صارت أكثر سماكة يعني إن عندها قابلية أكبر إنها
+
+82
+00:05:50,880 --> 00:05:55,260
+تستقبل الجنين و تعمله implantationوبتصير أكثر
+
+83
+00:05:55,260 --> 00:05:59,060
+سماكة من خلال زيادة المواد الغذائية وتضافة الدم
+
+84
+00:05:59,060 --> 00:06:04,100
+إلى هذه المنطقة Caused the mucus in the cervix to
+
+85
+00:06:04,100 --> 00:06:08,160
+thicken so that the sperm or bacteria are less
+
+86
+00:06:08,160 --> 00:06:11,880
+likely to enter the uterus بيخلّي المنطقة الـ
+
+87
+00:06:11,880 --> 00:06:16,160
+cervical .. الميوكاس المنطقة الـ cervical الكثافة
+
+88
+00:06:16,160 --> 00:06:19,800
+تبعتها عالية جدا فبصير الميوكاس more thick هذا
+
+89
+00:06:19,800 --> 00:06:24,370
+بيمنع أي sperm أو أي نوع من أنواع البكتيريا تدخلو
+
+90
+00:06:24,370 --> 00:06:28,930
+تخطأ منطقة الـ cervic و تصل للرحم فتعمل التهابات
+
+91
+00:06:28,930 --> 00:06:32,730
+حادة جدا في منطقة الرحم مما يؤدي إلى إيجاد الجنين
+
+92
+00:06:32,730 --> 00:06:35,810
+فالبروجيسترون بيمنع الكلام هذا شغل تانية
+
+93
+00:06:35,810 --> 00:06:39,230
+البروجيسترون بيعمل causing body temperature to
+
+94
+00:06:39,230 --> 00:06:43,630
+increase slightly during the UTL phase and remain
+
+95
+00:06:43,630 --> 00:06:47,870
+elevated until menstrual cycle period علشان يحفظ
+
+96
+00:06:47,870 --> 00:06:52,350
+هذا المنطقة أن يصير في أنه تجديد أضف إلى ذلك أنه
+
+97
+00:06:52,350 --> 00:06:56,400
+بيحفظ جهاز المناعةإن و الله في عندي شيء غريب هيحدث
+
+98
+00:06:56,400 --> 00:07:00,440
+في منطقة ال abdominal فلازم جهاز المناعة يظل محفظ
+
+99
+00:07:00,440 --> 00:07:06,100
+يحفظ جهاز المناعة من خلال ارتفاع درجة حرارة الجسم
+
+100
+00:07:06,100 --> 00:07:11,740
+بشكل تدريجي معناه جهاز المناعة عنده ميار معين
+
+101
+00:07:11,740 --> 00:07:17,110
+ارتفاع درجة الحرارة معناه ان في عندي حالةأو خطر أو
+
+102
+00:07:17,110 --> 00:07:21,330
+حالة من الاستعداد يجب أن يكون فيه من خلال الجهاز
+
+103
+00:07:21,330 --> 00:07:26,850
+المناعي لأي invasion ممكن يصير للجسم if the women
+
+104
+00:07:26,850 --> 00:07:30,070
+become pregnant إذا صار في عند ال fertilization
+
+105
+00:07:30,070 --> 00:07:33,430
+وشاء الأقدار وشاء الله ان يصير fertilization هيصير
+
+106
+00:07:33,430 --> 00:07:37,290
+هنا في ال fallopian tube يبدأ الجسم يفرز هرمون
+
+107
+00:07:37,290 --> 00:07:41,190
+بنسميه هرمون الحمل وهو عبارة عن ال betaHuman
+
+108
+00:07:41,190 --> 00:07:48,110
+Chronic Gonadotropin بيسموها Beta HCG
+
+109
+00:07:48,110 --> 00:07:54,290
+اختصار Beta H Human C Chronic G Gonadotropin طبعا
+
+110
+00:07:54,290 --> 00:08:00,410
+هذا الهرمون يفرز يسمى بهرمون الحملويتم إفرازه and
+
+111
+00:08:00,410 --> 00:08:04,850
+its help يتم إفرازه بمجرد حدوث ال fertilization من
+
+112
+00:08:04,850 --> 00:08:09,850
+قبل الجسم وظيفته الأساسية بيحفظ الـ corpus luteum
+
+113
+00:08:09,850 --> 00:08:14,630
+من أجل استمرار إفراز البروجسترون كمان هذا الـ Beta
+
+114
+00:08:14,630 --> 00:08:19,330
+-HCG يحفظ بطنط الرحم إنها تبقى thick ما يصير لها
+
+115
+00:08:19,330 --> 00:08:23,020
+thinningوبالتالي بيصير لها degradation بشكل سريء
+
+116
+00:08:23,020 --> 00:08:25,920
+During a pregnancy, all events of the menstrual
+
+117
+00:08:25,920 --> 00:08:30,000
+cycle will be stopped and there is no menstruation
+
+118
+00:08:30,000 --> 00:08:33,820
+خلال عملية الحمض وإذا صار في fertilization، كل
+
+119
+00:08:33,820 --> 00:08:37,580
+أحداث الدورة الشهرية كلها هتتوقف ومش هيصير a
+
+120
+00:08:37,580 --> 00:08:40,800
+bleeding في نهاية التمانية وعشرين يوم لإنه صار في
+
+121
+00:08:40,800 --> 00:08:45,290
+عندي جنينوالجنين يعني انغرز في بطانة الرحم يعني
+
+122
+00:08:45,290 --> 00:08:48,350
+بطانة الرحم لازم تبقى موجودة ومايصلهاش degradation
+
+123
+00:08:48,350 --> 00:08:51,570
+طب إذا ماصارش فيه pregnancy كل الهرمونات هذه
+
+124
+00:08:51,570 --> 00:08:55,710
+هتتغير هيبدأ الكوربس اليوتيام يوقف إفراز
+
+125
+00:08:55,710 --> 00:09:00,070
+لبروجسترون هيصير فيه شرينكش بشكل تدريجي ويصير له
+
+126
+00:09:00,070 --> 00:09:04,590
+degradation إفراز هرمون البروجسترون كمان في
+
+127
+00:09:04,590 --> 00:09:09,140
+المقابل يقلل إفراز هرمون الأستروجينكلهم يلعب دورة
+
+128
+00:09:09,140 --> 00:09:12,500
+سلبية على بطاطة الرحم، مما يؤدي إلى إضعافها
+
+129
+00:09:12,500 --> 00:09:18,180
+وتهتكها وتكسرها وخروجها مع ال bleeding في نهاية
+
+130
+00:09:18,180 --> 00:09:23,400
+هذا ال cycle والتي تعتبر بداية cycle جديدة هذا
+
+131
+00:09:23,400 --> 00:09:24,180
+بالنسبة إلى
+
+132
+00:09:27,980 --> 00:09:32,380
+هنتكلم ببساطة في صورة هي في عين دي Hypothalamic
+
+133
+00:09:32,380 --> 00:09:35,560
+وهو عبارة عن الـ Hypothalamus اللي بيفرز
+
+134
+00:09:35,560 --> 00:09:38,060
+الجريادوتروبين releasing hormone للناس اللي أخدت
+
+135
+00:09:38,060 --> 00:09:40,880
+اندوكراينولوجيا بأثر على الـ anterior loop
+
+136
+00:09:40,880 --> 00:09:44,040
+للبتيوتر الجلد فبيفرز ال FSH ال follicle
+
+137
+00:09:44,040 --> 00:09:48,660
+stimulating hormone وبيفرز ال utilizing hormone ال
+
+138
+00:09:48,660 --> 00:09:52,060
+follicle stimulating hormone وظيفته الأساسية بيحفظ
+
+139
+00:09:52,060 --> 00:09:56,500
+ال follicle للنضوج للوصول إلى الجريافية ال
+
+140
+00:09:56,500 --> 00:10:00,470
+follicleالـ Graphian Follicle بمجرد وصول الـ
+
+141
+00:10:00,470 --> 00:10:02,730
+Graphian Follicle إلى الـ Diameter المطلوب من 18
+
+142
+00:10:02,730 --> 00:10:07,930
+-36 ببدأ يفرز كمية كبيرة جدا من الـ Estrogen اللي
+
+143
+00:10:07,930 --> 00:10:10,910
+بحفظ الـ Anterolube للـ Pituitary Gland فتفرز الـ
+
+144
+00:10:10,910 --> 00:10:14,970
+Lactalizing Hormone اللي بيعمل Ovulation الفوليكل
+
+145
+00:10:14,970 --> 00:10:17,890
+هذه اللي صار فيها Ovulation تتحول إلى Corpus
+
+146
+00:10:17,890 --> 00:10:22,490
+Luteum من أجل إفراز هرمون للبروجسترون هذه فكرة
+
+147
+00:10:22,490 --> 00:10:27,030
+عمليةالدورة الشهرية أو الهرمونات الدورة الشهرية
+
+148
+00:10:27,030 --> 00:10:30,890
+عند السيدات خلّينا نشوف الفيديو اللي بتكلم عن هذه
+
+149
+00:10:30,890 --> 00:10:38,190
+العملية الـ
+
+150
+00:10:38,190 --> 00:10:41,470
+menstrual cycle is a term used to describe monthly
+
+151
+00:10:41,470 --> 00:10:44,130
+events that occur within a woman's body in
+
+152
+00:10:44,130 --> 00:10:48,270
+preparation for the possibility of pregnancy each
+
+153
+00:10:48,270 --> 00:10:50,570
+month an egg is released from an ovary
+
+154
+00:10:53,700 --> 00:10:58,220
+في نفس الوقت، يتحرر خطوط البرتقال لإستعداد الحضورة
+
+155
+00:10:58,220 --> 00:11:03,000
+إذا لم تتحرر الخطوط بالبرتقال لإستعداد الحضورة
+
+156
+00:11:03,000 --> 00:11:04,220
+لإستعداد الحضورة لإستعداد الحضورة لإستعداد الحضورة
+
+157
+00:11:04,220 --> 00:11:04,620
+لإستعداد الحضورة لإستعداد الحضورة لإستعداد الحضورة
+
+158
+00:11:04,620 --> 00:11:04,720
+لإستعداد الحضورة لإستعداد الحضورة لإستعداد الحضورة
+
+159
+00:11:04,720 --> 00:11:06,340
+لإستعداد الحضورة لإستعداد الحضورة لإستعداد الحضورة
+
+160
+00:11:06,340 --> 00:11:09,740
+لإستعداد الحضورة لإستعداد الحضورة لإستعداد الحضورة
+
+161
+00:11:09,740 --> 00:11:16,800
+لإستعداد الحضورة لإستعداد الحضورة لإستعداد
+
+162
+00:11:16,800 --> 00:11:19,760
+الحضورة لإستعداد الح
+
+163
+00:11:22,610 --> 00:11:26,010
+السيقل المنسوي يتحكم في الهرمونات التي يتم تحريرها
+
+164
+00:11:26,010 --> 00:11:32,290
+من الجلد والعضلات الجلد الهرموني نفسه يتحكم في
+
+165
+00:11:32,290 --> 00:11:37,150
+الهيبثالموس الهيبثالموس ينتج هرمون يدعى
+
+166
+00:11:37,150 --> 00:11:44,090
+غوندوترابين ريليسينغ هورمون أو GNRH GNRH يدفع جذب
+
+167
+00:11:44,090 --> 00:11:47,670
+الهرمون الهرموني لتحرير الهرمون الهرموني يدفع
+
+168
+00:11:47,670 --> 00:11:53,230
+الهرمون الهرموني لتحريرالـ FSH تسير في مصادر الدم
+
+169
+00:11:53,230 --> 00:11:58,750
+إلى الأعضاء ويعزز مجموعة من الفوليكولات لتنمو هذه
+
+170
+00:11:58,750 --> 00:12:02,330
+الفوليكولات الأساسية تتطور إلى فوليكولات أساسية ثم
+
+171
+00:12:02,330 --> 00:12:06,710
+فوليكولات ثانوية هذه الفوليكولات تنتج هرمون اسمه
+
+172
+00:12:06,710 --> 00:12:10,350
+أستراجين وهو يعمل لإنشطة تنمو تطور الاندومتريا
+
+173
+00:12:10,350 --> 00:12:15,190
+الانترالي من الجلد الفوليكولات
+
+174
+00:12:15,190 --> 00:12:17,430
+الثانوية تقاتلوا مع بعضها البعض وإلا واحد منهم
+
+175
+00:12:17,430 --> 00:12:22,060
+سيبقى ماتور من الفوليكولةوالباقي يتعذب ويموت.
+
+176
+00:12:23,420 --> 00:12:26,200
+مستوى المزيد من الأسترجان يعمل أيضًا على الـ
+
+177
+00:12:26,200 --> 00:12:31,180
+hypothalamus ومعينة الأمامية لإزالة مستوى الـ GNRH
+
+178
+00:12:31,180 --> 00:12:37,920
+ويجعله ينتج هرمون آخر، هرمون الـ LH. تشغّل تشغف
+
+179
+00:12:37,920 --> 00:12:42,840
+الـ LH تشغّف الـ ovulation. إطلاق الأجهزة من
+
+180
+00:12:42,840 --> 00:12:47,200
+الفولجل والأعضاء. والأجهزة ثم تسحق من الـ Fembrae
+
+181
+00:12:47,200 --> 00:12:52,120
+ويتخلص من مخصصة الـ uterineFertilization by a
+
+182
+00:12:52,120 --> 00:12:55,540
+spermatozoan when it occurs usually takes place in
+
+183
+00:12:55,540 --> 00:12:58,100
+the ampulla, the widest section of the fallopian
+
+184
+00:12:58,100 --> 00:13:01,660
+tube لذن عملية ال fertilization بتصير في ال
+
+185
+00:13:01,660 --> 00:13:04,740
+fallopian tube في منطقة بيسموها ال ambula في منطقة
+
+186
+00:13:04,740 --> 00:13:09,120
+بيسموها ال ambula لأن هذا المصطلح هيمر علينا قدام
+
+187
+00:13:09,120 --> 00:13:11,760
+ال fertilized egg immediately begins the process
+
+188
+00:13:11,760 --> 00:13:14,880
+of development while traveling towards the uterus
+
+189
+00:13:14,880 --> 00:13:20,410
+after six days it becomes a blastocystوهي مصابة في
+
+190
+00:13:20,410 --> 00:13:24,710
+الاندومتريوم في الجلد طبعا بعد كده البوايضة
+
+191
+00:13:24,710 --> 00:13:28,210
+المخصبة هتنتقل إلى الرحم وتنغلط في بطانة الرحم في
+
+192
+00:13:28,210 --> 00:13:32,030
+مرحلة معينة إلى أقسم معين هتتكلم عنه لما نصل ل ال
+
+193
+00:13:32,030 --> 00:13:37,690
+embryo grading و ال embryo typing meanwhile the
+
+194
+00:13:37,690 --> 00:13:40,210
+leftover of the ruptured follicle has become a
+
+195
+00:13:40,210 --> 00:13:42,930
+corpus luteum which secretes progesterone
+
+196
+00:13:42,930 --> 00:13:46,150
+Progesterone further stimulates uterine
+
+197
+00:13:46,150 --> 00:13:50,440
+developmentتجعلها مجلد مدعوم للمجلد في حالة
+
+198
+00:13:50,440 --> 00:13:55,620
+الحفاظة في مفاوضة الحفاظة، يتخلص الكوربوسلوثيوم
+
+199
+00:13:55,620 --> 00:14:01,080
+ويتخلص مستوى البروجسترون هذا يعيد إلى انتقال من
+
+200
+00:14:01,080 --> 00:14:04,760
+الاندومتريوم، يبدأ الانتقال ويبدأ السيكلية بالعكس
+
+201
+00:14:04,760 --> 00:14:11,040
+طبعا
+
+202
+00:14:11,040 --> 00:14:13,720
+هذه الكلام تخلق الدورة الشهرية وأحداث الدورة
+
+203
+00:14:13,720 --> 00:14:17,970
+الشهرية والهرمونات التيتنتج من الـ Gonadotropin من
+
+204
+00:14:17,970 --> 00:14:20,150
+الـ hypotalamus متمثل في الـ gonadotropin الـ
+
+205
+00:14:20,150 --> 00:14:23,230
+releasing hormone من الـ pituitary gland متوسطة في
+
+206
+00:14:23,230 --> 00:14:26,950
+الـ FSH و الـ LH و من ال corpus luteum متمثل
+
+207
+00:14:26,950 --> 00:14:32,030
+بالبروجسترون و من ال follicular متمثل بالـ E2
+
+208
+00:14:32,030 --> 00:14:35,670
+متمثل بالـ E2 طبعا كل هذه الهرمونات مهمة جدا كل
+
+209
+00:14:35,670 --> 00:14:41,180
+واحد له وظيفة معينة مصدر معينوأهمية معينة خلال
+
+210
+00:14:41,180 --> 00:14:46,200
+عملية menstrual cycle للوصول إلى pregnancy status
+
+211
+00:14:46,200 --> 00:14:51,860
+طبعا هذه شكل ومنحنيات الهرمونات طبعا في عند ال FSH
+
+212
+00:14:51,860 --> 00:14:54,600
+والالاتش يفرز من ال anterior loop للبطولة رجلان
+
+213
+00:14:54,600 --> 00:15:01,960
+يفرز ال FSH على شكل مستمر والالاتش يفرز ب high
+
+214
+00:15:01,960 --> 00:15:07,510
+peak في مرة واحدة فقط لغير وهي عبارة عنلحظة
+
+215
+00:15:07,510 --> 00:15:11,070
+الطبويد اللي بتسميها لحظة الطبويد وهي الـLH wave
+
+216
+00:15:11,070 --> 00:15:16,370
+triggered for ovulation هاي المراحل تدور البويضة
+
+217
+00:15:16,370 --> 00:15:19,850
+من primordial germ cell primary oocyte، secondary
+
+218
+00:15:19,850 --> 00:15:25,510
+oocyte، follicle، single follicle، الـgraphian
+
+219
+00:15:25,510 --> 00:15:29,230
+follicle، وبعدين ال ovulation، corpus luteum، لما
+
+220
+00:15:29,230 --> 00:15:33,270
+يصير له degeneration في الـUTL phase
+
+221
+00:15:34,540 --> 00:15:38,760
+الـ Ovarian hormone أول هرمون يفرز هو الأستروجين
+
+222
+00:15:38,760 --> 00:15:43,680
+لأنه يفرز من البويضات أو الفوليكل التي تبدأ بتطور
+
+223
+00:15:43,680 --> 00:15:48,180
+ونضوج ثم بعد ال ovulation يبدأ إفراز هرمون
+
+224
+00:15:48,180 --> 00:15:52,020
+لبروجسترون الكوربوس اليوتيام طبعا هذه المراحل
+
+225
+00:15:52,020 --> 00:15:55,020
+بيصير فيها ال bleeding أول دورة شهرية بيصير فيها
+
+226
+00:15:55,020 --> 00:15:59,880
+end bleeding من خلال تهتق وتمزق قطعة الرحمعملية
+
+227
+00:15:59,880 --> 00:16:02,980
+قبل الـ ovulation تبدأ الـ endomaterium يصير لها
+
+228
+00:16:02,980 --> 00:16:06,600
+عملية regeneration مرة أخرى علشان تستقبل البوايضة
+
+229
+00:16:06,600 --> 00:16:11,180
+المقصبة البوايضة المقصبة في حالة تخزي باب الاسفلان
+
+230
+00:16:11,180 --> 00:16:16,580
+طيب في بعض الحالات ممكن يزيد ال duration خاصة بين
+
+231
+00:16:16,580 --> 00:16:19,800
+ال menstrual cycle في بعض الحالات يزيد أكتر لعدة
+
+232
+00:16:19,800 --> 00:16:24,920
+أسباب السبب الأول أنه صير في عندي عدم انتظام في
+
+233
+00:16:24,920 --> 00:16:27,980
+الهرمونات السبب الأول أنه الهرمونات out of work
+
+234
+00:16:27,980 --> 00:16:32,240
+خارج العملالورومات بتكون out of work يعني out of
+
+235
+00:16:32,240 --> 00:16:36,920
+control خارج العمل خارج .. خارج قلية التنظيم و هذا
+
+236
+00:16:36,920 --> 00:16:40,540
+بيصير من خلال ال PCO الـ Polycystic Ovarian
+
+237
+00:16:40,540 --> 00:16:44,980
+Syndrome اللي اتكلمنا عليها وهي عبارة عن أن ..
+
+238
+00:16:44,980 --> 00:16:48,780
+عبارة عن خلق .. يعني عبارة عن حالة تؤدي إلى إفقاد
+
+239
+00:16:48,780 --> 00:16:52,700
+المبيض وظيفته يعني بتصير عند الفليل اللي بتنمو و
+
+240
+00:16:52,700 --> 00:16:56,480
+مافيها بويضة مضجة أو ممكن يكون under reacted أو
+
+241
+00:16:56,480 --> 00:17:02,670
+over ..underactive أو overactive للـ thyroid gland
+
+242
+00:17:02,670 --> 00:17:06,030
+اللي بتفرز هرمون الـ thyroid hormone and other
+
+243
+00:17:06,030 --> 00:17:11,710
+disorders that affected in the sex hormone in
+
+244
+00:17:11,710 --> 00:17:17,390
+female من أشهرها أو هذه الأمور اللي اتكلمنا عليها
+
+245
+00:17:17,390 --> 00:17:21,990
+سواء كانت الـ PCO أو زيادة نشاط أو نقصان نشاط
+
+246
+00:17:21,990 --> 00:17:27,560
+هرمون هرمون المفرز من الغدة الدراقيةيؤدي إلى زيادة
+
+247
+00:17:27,560 --> 00:17:32,360
+طول الدورة كالوقت اللي تستهلكه بدل سبع أيام أو
+
+248
+00:17:32,360 --> 00:17:35,960
+متوسط خمس أيام تصبح عشرة أو سبعة أو تمانية وتصبح
+
+249
+00:17:35,960 --> 00:17:40,200
+الدورة heavy و irregular أيضا بعض ال medication
+
+250
+00:17:40,200 --> 00:17:44,960
+إذا كانت السيدة بتاخد thyroid medication، citroid
+
+251
+00:17:44,960 --> 00:17:51,540
+بعض الأدوية بتعمل على تأثير سلبي على ال sex
+
+252
+00:17:51,540 --> 00:17:54,800
+hormone الخاصة فيها زي الفسادش والالاتشفبالتالي
+
+253
+00:17:54,800 --> 00:17:57,180
+بيغير من طبيعة الدورة، بيغير من ال evaluation
+
+254
+00:17:57,180 --> 00:18:01,600
+للدورة، عشان كده أي سيدة بتتناول هرمونات اللي هي
+
+255
+00:18:01,600 --> 00:18:04,620
+علاقة بالسترويد هرمون أو بتتناول medication اللي
+
+256
+00:18:04,620 --> 00:18:08,920
+هي علاقة بالثيرويد medication أو السترويد هرمون،
+
+257
+00:18:08,920 --> 00:18:11,720
+لازم تتأكد من الكمية اللي بتاخدها أو الكيفية اللي
+
+258
+00:18:11,720 --> 00:18:15,820
+بتاخد فيهاExposure to environment estrogen بعض
+
+259
+00:18:15,820 --> 00:18:19,820
+الأحيان بعض السيدات بتتعرض لهرمونات من ال
+
+260
+00:18:19,820 --> 00:18:22,440
+environment خاصة الهرمونات اللي بتتواجد في ال
+
+261
+00:18:22,440 --> 00:18:27,780
+plastic material ال plastic product ال pesticide
+
+262
+00:18:27,780 --> 00:18:32,800
+تناول لحوم لأبقار معالجة بالهرمونات يعني كأنها
+
+263
+00:18:32,800 --> 00:18:37,380
+بتاخد هرمون من مصدر آخر فهذا بيخل الهرمونات داخل
+
+264
+00:18:37,380 --> 00:18:42,980
+الجسم out of control فبيغير مدى استجابةالـ Ovary
+
+265
+00:18:42,980 --> 00:18:47,280
+لهذه الهرمونات فبؤدي إلى تغيير طبيعة الدورة من حيث
+
+266
+00:18:47,280 --> 00:18:50,800
+ال duration أيضًا من الأسباب التي تؤدي إلى زيادة
+
+267
+00:18:50,800 --> 00:18:55,380
+فترة الدورة الدموية اكتساب الوزن أو ال stress بعض
+
+268
+00:18:55,380 --> 00:18:58,300
+السيدات لو زاد وزنها عن الوزن المطلوب أو الوزن
+
+269
+00:18:58,300 --> 00:19:01,760
+الصحيح أو الوزن المثالي خلّينا نسميهبناء على ال
+
+270
+00:19:01,760 --> 00:19:04,880
+body mass index يصير فيه عدة fluctuation أو
+
+271
+00:19:04,880 --> 00:19:08,420
+irregularity في ال menstrual cycle ال menstrual
+
+272
+00:19:08,420 --> 00:19:13,600
+cycle بتكون irregular أيضا ال stress القلق يؤدي
+
+273
+00:19:13,600 --> 00:19:19,800
+إلى انقاص العمر بشكل حرفي لأن القلق مسئول عنإنقاص
+
+274
+00:19:19,800 --> 00:19:24,440
+العمر الافتراضي للخلايا هذا كما قلت على مرحلة من
+
+275
+00:19:24,440 --> 00:19:28,160
+ناحية الـ Genetics القلق يودع إلى انقاص التلومير
+
+276
+00:19:28,160 --> 00:19:32,040
+فالتلومير يعمل على إفقاد الخلية قدرتها على البقاء
+
+277
+00:19:32,040 --> 00:19:36,180
+فبصرا destructure أيضا القلق بيعمل fluctuation في
+
+278
+00:19:36,180 --> 00:19:39,560
+ال hormones بشكل عام ومن أشهرهم ال six hormones زي
+
+279
+00:19:39,560 --> 00:19:43,240
+ال FSH و ال LH فبيدّي الحالة النفسية إلى فقدان
+
+280
+00:19:43,240 --> 00:19:50,400
+السيدةأو فقدان الزوج الذكر الرغبة في الإنجاب مما
+
+281
+00:19:50,400 --> 00:19:55,020
+يؤدي إلى تأخر الإنجاب فما بالك هذا على سعيد تأخر
+
+282
+00:19:55,020 --> 00:19:59,020
+الإنجاب كمشكلة عامة فما بالك على سعيد ال phases
+
+283
+00:19:59,020 --> 00:20:02,020
+الخاصة بتدورة ممكن تصير fluctuation في مستوى
+
+284
+00:20:02,020 --> 00:20:04,900
+الهرمونات في كمية الهرمونات في كيفية افراز
+
+285
+00:20:04,900 --> 00:20:09,760
+الهرمونات فبالتالي بيصير في اندي increasing in the
+
+286
+00:20:09,760 --> 00:20:15,300
+duration of menstrual cycleخلصنا من الـ Female و
+
+287
+00:20:15,300 --> 00:20:19,940
+الهرمونات الخاصة بها، سنتحدث عن الهرمون الخاص بال
+
+288
+00:20:19,940 --> 00:20:24,300
+Male هل هناك هرمونات خاصة بال Male Reproductive
+
+289
+00:20:24,300 --> 00:20:28,900
+System مغيرة عن الهرمونات التي ذُكرت في ال Female؟
+
+290
+00:20:28,900 --> 00:20:31,420
+معظم الهرمونات متشابهة باستثناء الـ Testosterone
+
+291
+00:20:32,880 --> 00:20:37,580
+الذكورة لا يوجد إلا عند الذكور يوجد عند الإينات
+
+292
+00:20:37,580 --> 00:20:42,460
+بكمية قليلة جدا تكاد لا تذكر ولكن يبدأ بالزيادة
+
+293
+00:20:42,460 --> 00:20:46,280
+بعد ال rest well cycle عشان كده السيدة بعد سن
+
+294
+00:20:46,280 --> 00:20:51,880
+إقطاع الطنف بيبدأ عندها زيادة في حجم العظم
+
+295
+00:20:51,880 --> 00:20:57,220
+بالإضافة إلى خشورة في الصوم فبالتالي ال hormones
+
+296
+00:20:57,220 --> 00:20:59,960
+and reproduction in male
+
+297
+00:21:02,970 --> 00:21:05,670
+الـ Gonadotropin-releasing hormone اللي بيأثر على
+
+298
+00:21:05,670 --> 00:21:09,270
+الـ anterior loop للبطيوريجلان فبيفرز الـ FSH والـ
+
+299
+00:21:09,270 --> 00:21:14,810
+LH الـ LH يستطيله ريسبتور تقدر بـ 20 ألف ريسبتور
+
+300
+00:21:14,810 --> 00:21:17,510
+موجودة على سطح الـ leading cells الموجودة في الـ
+
+301
+00:21:17,510 --> 00:21:21,950
+testes فمجرد إفراز الـ LH من خلال الـ anterior
+
+302
+00:21:21,950 --> 00:21:25,710
+loop للبطيوريجلان ينقل عبر الدم إلى الـ leading
+
+303
+00:21:25,710 --> 00:21:31,010
+cell الموجودة في الـ testes الخاصة بالمياه هذا الـ
+
+304
+00:21:31,010 --> 00:21:34,310
+l-autolizing hormoneيحفظ الـ leading cell على
+
+305
+00:21:34,310 --> 00:21:39,290
+إنتاج التستيستيرون ينتج من ماذا؟ ينتج من مادة مهمة
+
+306
+00:21:39,290 --> 00:21:43,990
+جدا الكوليسترول إذا الكوليسترول هو المكون الأساسي
+
+307
+00:21:43,990 --> 00:21:48,150
+للـ sex hormone بشكل أساسي التستيستيرون بمجرد
+
+308
+00:21:48,150 --> 00:21:50,590
+إفرازه من ال leading cell is released in the blood
+
+309
+00:21:50,590 --> 00:21:55,310
+and is taken to the sirtuolar cell بمجرد أن ال
+
+310
+00:21:55,310 --> 00:21:58,170
+leading cell تستقبل الـ H تفرز التستيستيرون
+
+311
+00:21:58,170 --> 00:22:02,170
+التستيستيرون ينقل عبر الدمإلى مناطق مختلفة من
+
+312
+00:22:02,170 --> 00:22:05,530
+الجسم وقامها الـ Sertoli cell الموجودة في التستس
+
+313
+00:22:05,530 --> 00:22:10,190
+أيضًا بمجرد وصولها إلى ال Sertoli cell أو وصولها
+
+314
+00:22:10,190 --> 00:22:12,810
+إلى ال Sertoli cell where it is affected in the
+
+315
+00:22:12,810 --> 00:22:15,570
+secondary sexual tissue يعني بأثر على ال Sertoli
+
+316
+00:22:15,570 --> 00:22:19,290
+cell و بأثر أيضًا على أنسجة أخرى في الجسم هنتكلم
+
+317
+00:22:19,290 --> 00:22:23,310
+عنها زي مثلًا ال muscles بيزيد ال thickness لل
+
+318
+00:22:23,310 --> 00:22:29,790
+musclesالعظم بيزيد كثافة العظم الصوت بيزيد خشونة
+
+319
+00:22:29,790 --> 00:22:33,630
+الصوت عند الذكور أيضًا في بعض المناطق اللي بتعمل
+
+320
+00:22:33,630 --> 00:22:37,830
+على ذبور الصفات الذكورية الثانوية السيرتول السيل
+
+321
+00:22:37,830 --> 00:22:42,350
+مهم جدًا طبعًا بمجرد أنه يصير لها stimulation
+
+322
+00:22:42,350 --> 00:22:47,190
+للسيرتول السيل بفعل هرمون اسمه FSH تفرز السيرتول
+
+323
+00:22:47,190 --> 00:22:51,280
+السيل مادة تسمى Androgen Binding Proteinهذا
+
+324
+00:22:51,280 --> 00:22:54,760
+الاندروجين binding البروتين يعتبر carrier for
+
+325
+00:22:54,760 --> 00:22:59,220
+تستيستيرون برتبط مع التستيستيرون وبيعمل الى نقله
+
+326
+00:22:59,220 --> 00:23:03,200
+الى مناطق مختلفة من أشهرها الـ seminal vestibule
+
+327
+00:23:03,200 --> 00:23:07,080
+وهو المكان اللذي يصنع فيه الـ sperm with its
+
+328
+00:23:07,080 --> 00:23:11,980
+strong influence of the course of spermatogenesis
+
+329
+00:23:11,980 --> 00:23:15,860
+يعني hypothalamus بيفرز غنادوتروبين رياليزين
+
+330
+00:23:15,860 --> 00:23:19,260
+كورموت بأثر على الانتروليوبل البتوتة رجلات بتفرز
+
+331
+00:23:19,260 --> 00:23:24,870
+FSHالـ LH يُنقل إلى الـ leading cell ويؤثر عليها
+
+332
+00:23:24,870 --> 00:23:30,930
+تفرز التستيسترون من الكوليسترون التستيسترون يُنقل
+
+333
+00:23:30,930 --> 00:23:34,750
+في الدم فيؤثر على السيرتولوسيل السيرتولوسيل بتفرز
+
+334
+00:23:34,750 --> 00:23:37,910
+مادة عبارة عن carrier protein بتسمى أندروجين
+
+335
+00:23:37,910 --> 00:23:41,950
+binding protein يرتبط مع التستيسترون ويعمل على نقل
+
+336
+00:23:41,950 --> 00:23:46,550
+التستيسترون إلى مناطق مختلفة طيب السيرتولوسيل
+
+337
+00:23:46,550 --> 00:23:50,980
+productionالسيرتولاسيل تنتج أيضًا نوع آخر من
+
+338
+00:23:50,980 --> 00:23:54,540
+الهرمون يسمى انهيبين طبعًا هذا الانهيبين اللي تم
+
+339
+00:23:54,540 --> 00:23:58,620
+تحميله من البلد إلى الانترويد البتوتري وممكنًا إلى
+
+340
+00:23:58,620 --> 00:24:03,120
+الهيبوتالماص الانهيبين يعمل كتابة ناجحة لإنهيبط
+
+341
+00:24:03,120 --> 00:24:09,400
+سكريشة الـSFS طبعًا بمجرد أن السيرتولاسيل تتأثر
+
+342
+00:24:09,400 --> 00:24:12,800
+بالتستسترول هتفرز الكاريهر بروتين اللي اسمه
+
+343
+00:24:12,800 --> 00:24:16,120
+أندروجين وويندنج بروتيناللي برتبط مع الـ
+
+344
+00:24:16,120 --> 00:24:19,700
+Testosterone وضُنطق له لمناطق مختلفة من الجسم أهم
+
+345
+00:24:19,700 --> 00:24:21,900
+الـ seminiferous tubule الموجودة في الـ Testis
+
+346
+00:24:21,900 --> 00:24:26,240
+اللي تعتبر مصنع الـ spermatocyte أيضًا الـ
+
+347
+00:24:26,240 --> 00:24:29,280
+Sirtolocin لا تكتفي بهذا الأمر بل تقوم بإفراز
+
+348
+00:24:29,280 --> 00:24:33,300
+هرمون آخر اسمه الانهيبين هذا الانهيبين هو المنظم
+
+349
+00:24:33,300 --> 00:24:37,180
+اللي ممكن يصل إلى الـ anterior lobe للبطيوتر جلان
+
+350
+00:24:37,180 --> 00:24:41,540
+وإلى الـ hypothalamus ويعملهم shutdown بمعنى آخر
+
+351
+00:24:41,540 --> 00:24:45,860
+مش shutdown completelyلأ، بيعمل إيقاف لإفراز هرمون
+
+352
+00:24:45,860 --> 00:24:49,800
+الـ FSH طيب، what is the function أو what is the
+
+353
+00:24:49,800 --> 00:24:52,580
+major function of sertolysol؟ أول حاجة بتعمل
+
+354
+00:24:52,580 --> 00:24:56,840
+maintenance لـ blood testis spires الحواجز
+
+355
+00:24:56,840 --> 00:25:00,480
+الموجودة بين الدورة الدموية والتستس المسئولة عن ال
+
+356
+00:25:00,480 --> 00:25:04,240
+maintenance الخاص بيها ال sertolysol وإلا، حيصير
+
+357
+00:25:04,240 --> 00:25:07,820
+في direct contact ما بين blood circulation و ال
+
+358
+00:25:07,820 --> 00:25:12,420
+testis ويعمل الجسم Antibody ضد ال sperm، ضد نفسهأي
+
+359
+00:25:12,420 --> 00:25:15,580
+شغلة .. شغلة تانية Secretion of tubular fluid مهم
+
+360
+00:25:15,580 --> 00:25:18,900
+جدا Secretion of androgen binding protein اللي
+
+361
+00:25:18,900 --> 00:25:22,360
+تحكينا فيها قبل بشوية Secretion of estrogen and
+
+362
+00:25:22,360 --> 00:25:25,300
+inhibin و الانهيبين مهم جدا في عملية ال regulation
+
+363
+00:25:25,300 --> 00:25:30,360
+Secretion of a wide number of other proteins vary
+
+364
+00:25:30,360 --> 00:25:36,140
+growth factor Transferrin أضافة إلى هرمون أخر مثلا
+
+365
+00:25:36,140 --> 00:25:41,180
+binding protein هذا مهم جدا Maintenance and
+
+366
+00:25:41,510 --> 00:25:44,450
+coordination of spermatogenesis بتعمل maintenance
+
+367
+00:25:44,450 --> 00:25:49,010
+لعملية الـ spermatogenesis وبتعمل تنصيب متى ينتقل
+
+368
+00:25:49,010 --> 00:25:53,470
+من الـ type A لtype B الفيروس الـ spermatocyte لسا
+
+369
+00:25:53,470 --> 00:25:56,830
+كان spermatocyte هذا كلها مسئولة على الـ Sertoli
+
+370
+00:25:56,830 --> 00:26:00,130
+cell عشان كده الـ Sertoli cell قلنا في البداية أن
+
+371
+00:26:00,130 --> 00:26:04,270
+one Sertoli cell تستطيع أن تدعم إنتاج خمسين من
+
+372
+00:26:04,270 --> 00:26:09,000
+تلاتين لخمسين spermatocyte أو spermVagocytosis of
+
+373
+00:26:09,000 --> 00:26:12,620
+residual body of sperm cell مسئولة عنها السرطولسل
+
+374
+00:26:12,620 --> 00:26:16,800
+فالسرطولسل لها أكتر من function خلّينا نشوف
+
+375
+00:26:16,800 --> 00:26:22,980
+الفيديو اللي بتكلم عن الهرمون الخاص بالذكور وكيف
+
+376
+00:26:22,980 --> 00:26:30,520
+مسئولة عن إنتاج ال spermatocyte Testosterone
+
+377
+00:26:30,520 --> 00:26:31,000
+production
+
+378
+00:26:34,110 --> 00:26:37,490
+الـ Hypothalamus تطلع غناطوتروبين تطلع الحرمون أو
+
+379
+00:26:37,490 --> 00:26:42,670
+GNRH في حركتين كل 60 إلى 90 دقيقة لتشغّل تطلع
+
+380
+00:26:42,670 --> 00:26:49,710
+الحرمون الـ LH من الجلد الحمضي إلى دماغه الـ LH
+
+381
+00:26:49,710 --> 00:26:53,570
+يجمع الحرمون الـ LH على الجلدات اللاديكية للتاستيز
+
+382
+00:26:56,150 --> 00:26:58,670
+Binding initiates a cascade of events, which
+
+383
+00:26:58,670 --> 00:27:01,610
+include the conversion of cholesterol, depicted as
+
+384
+00:27:01,610 --> 00:27:05,050
+LDL here, to pregnenolone, followed by a series of
+
+385
+00:27:05,050 --> 00:27:07,810
+reactions, which convert pregnenolone to
+
+386
+00:27:07,810 --> 00:27:12,050
+testosterone Testosterone
+
+387
+00:27:12,050 --> 00:27:14,750
+secreted by the testes diffuses into the
+
+388
+00:27:14,750 --> 00:27:17,190
+peripheral circulation to be carried to target
+
+389
+00:27:17,190 --> 00:27:24,310
+tissues In liver .. طبعا في بعض ال .. ال .. ال ..
+
+390
+00:27:24,310 --> 00:27:24,630
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+391
+00:27:24,630 --> 00:27:25,030
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+392
+00:27:25,030 --> 00:27:25,930
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+393
+00:27:25,930 --> 00:27:25,950
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+394
+00:27:25,950 --> 00:27:25,950
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+395
+00:27:25,950 --> 00:27:25,950
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+396
+00:27:25,950 --> 00:27:25,950
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+397
+00:27:25,950 --> 00:27:25,950
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+398
+00:27:25,950 --> 00:27:27,680
+ال .. ال .. ال ..الـ Equation مش مطالبين فيها In
+
+399
+00:27:27,680 --> 00:27:30,700
+genital and adipose tissue تستاسترون binds
+
+400
+00:27:30,700 --> 00:27:34,380
+directly to its androgen receptor or AR to exert
+
+401
+00:27:34,380 --> 00:27:38,840
+its biological effect In skin, hair, the prostate
+
+402
+00:27:38,840 --> 00:27:42,460
+gland and gonadal tissue تستاسترون must be
+
+403
+00:27:42,460 --> 00:27:46,660
+converted to dihydrotestosterone or DHT by five
+
+404
+00:27:46,660 --> 00:27:49,440
+alpha reductase in order to bind the androgen
+
+405
+00:27:49,440 --> 00:27:55,060
+receptor In bone and brain, testosterone is
+
+406
+00:27:55,060 --> 00:27:55,720
+converted by
+
+407
+00:28:00,140 --> 00:28:04,400
+وانتقل إلى ميكروفون الأستراجين E2R لتحمل تأثيره
+
+408
+00:28:06,740 --> 00:28:09,920
+هذا بالنسبة إلى الهرمونات اللي هي علاقة بالذكور
+
+409
+00:28:09,920 --> 00:28:14,180
+بشكل أساسي كيف تفرز و من أين تفرز و كيف تساهم في
+
+410
+00:28:14,180 --> 00:28:18,300
+العملية هذه الصورة تؤكد العملية مرة أخرى هي عند
+
+411
+00:28:18,300 --> 00:28:20,720
+الـ hypothalamus وهو عبارة عن الـmaster gland
+
+412
+00:28:20,720 --> 00:28:25,080
+الخاص بالجسم بتحكم بكل شيء له علاقة بالجسم بيفرز
+
+413
+00:28:25,080 --> 00:28:28,120
+هرمون اسمه gonadotropin-releasing hormone اللي
+
+414
+00:28:28,120 --> 00:28:30,700
+بنتقل إلى الـanterior loop للبطيوتر الجلمد هذا
+
+415
+00:28:30,700 --> 00:28:33,960
+اللون الأبيض الانتريو وهذا اللون الغامق الاستيريو
+
+416
+00:28:34,990 --> 00:28:38,770
+طبعا بيتكلم إنه في عندي أسهم باللون الأحمر دايما
+
+417
+00:28:38,770 --> 00:28:43,370
+بتعمل enhancing بتعمل stimulation واللي باللون ال
+
+418
+00:28:43,370 --> 00:28:46,770
+bare ball بتعمل depression أو بتعمل reduction أو
+
+419
+00:28:46,770 --> 00:28:51,470
+بتعمل feedback يعني كأنها بتعمل عملية إنقاص في
+
+420
+00:28:51,470 --> 00:28:55,490
+كمية الهرمون المفرز إذا بتعمل inhibitor إذا اللي
+
+421
+00:28:55,490 --> 00:28:58,310
+بالأحمر بتعمل stimulation واللي بال bare ball
+
+422
+00:28:58,310 --> 00:29:01,690
+بتعمل inhibition طبعا gonadotropin raising hormone
+
+423
+00:29:01,690 --> 00:29:04,910
+بيأثر على ال anterior loop للبطيوتر الجلانبيفرز
+
+424
+00:29:04,910 --> 00:29:09,310
+الـ FSH وبيفرز الـ LH الـ LH يُنقل إلى الـ Target
+
+425
+00:29:09,310 --> 00:29:11,930
+Cell وهي الـ Leading Cell لأن الـ Receptor موجود
+
+426
+00:29:11,930 --> 00:29:15,290
+على سطحها فبتفرز رمون الـ Testosterone الـ
+
+427
+00:29:15,290 --> 00:29:18,750
+Testosterone يُنطقى .. يُنقل إلى مناطق مختلفة من
+
+428
+00:29:18,750 --> 00:29:23,430
+أجل إظهار الصفات الذكورية الثانوية فيُنقل إلى
+
+429
+00:29:23,430 --> 00:29:26,630
+البرستاتا، يُنقل إلى ال muscles، يُنقل إلى
+
+430
+00:29:26,630 --> 00:29:29,610
+الepidermis، يُنقل إلى ال seminal vesicles وخلافه
+
+431
+00:29:29,980 --> 00:29:33,420
+كمان ينقل إلى الـ Sertolicil فيحفظ الـ Sertolicil
+
+432
+00:29:33,420 --> 00:29:37,000
+تحت
+
+433
+00:29:37,000 --> 00:29:42,180
+تأثير الـ FSH-Hormone ستفرز مادة بسميها Androgen
+
+434
+00:29:42,180 --> 00:29:46,500
+Binding Protein الـ Androgen Binding Protein برتبط
+
+435
+00:29:46,500 --> 00:29:49,520
+مع الـ Testosterone وبينقله إلى الـ
+
+436
+00:29:49,520 --> 00:29:54,140
+Semipnephrostibule المسؤول عن إنتاجالـ
+
+437
+00:29:54,140 --> 00:29:58,540
+spermatocyte طب خلص وظيفته أيضًا السيرتول السيل
+
+438
+00:29:58,540 --> 00:30:02,160
+طالما خلصت وظيفتها هتفرز هرمون اسمه الانهيبين
+
+439
+00:30:02,160 --> 00:30:05,180
+باللون البربول فبتأثر على الـ anterolube و
+
+440
+00:30:05,180 --> 00:30:08,280
+الباتيوترجلان بتعملها negative feedback و بتأثر
+
+441
+00:30:08,280 --> 00:30:13,000
+على الhypothalamus أيضًا التستسترون قد وظيفته
+
+442
+00:30:13,000 --> 00:30:16,560
+هيشتغل على الhypothalamus فيعمله negative
+
+443
+00:30:16,560 --> 00:30:20,460
+inhibition أو inhibitor وعلى ال anterolube
+
+444
+00:30:20,460 --> 00:30:25,980
+للباتيوترجلانبالإضافة إلى إن الـ Sirtolacel بعد ما
+
+445
+00:30:25,980 --> 00:30:29,500
+تخلص الوظيفة المطلوبة منها ويكون أفرزة الكمية
+
+446
+00:30:29,500 --> 00:30:32,560
+المطلوبة من الهرمونات المسؤولة عن تصنيع الـ
+
+447
+00:30:32,560 --> 00:30:36,420
+spermatozoa تعمل على إفراز هرمون اسمه الـ Estrogen
+
+448
+00:30:36,420 --> 00:30:39,920
+leading cell stimulating factor هذا الـ Estrogen
+
+449
+00:30:39,920 --> 00:30:47,170
+يعمل أيضًا على تحفيزالـ leading cell لإستمرار
+
+450
+00:30:47,170 --> 00:30:50,850
+إفراز الـ testosterone عند الحاجة أو يفبطها عند
+
+451
+00:30:50,850 --> 00:30:55,050
+انتهاء الوظيفة المطلوبة منها إذا في عندي two
+
+452
+00:30:55,050 --> 00:30:58,950
+arrows red for stimulation و purple for inhibitor
+
+453
+00:30:58,950 --> 00:31:01,470
+نفس الهرمون ممكن يعمل inhibition و يعمل
+
+454
+00:31:01,470 --> 00:31:05,970
+stimulation أو ممكن هرمون آخر يفرز من نفس ال cells
+
+455
+00:31:05,970 --> 00:31:09,250
+من أجل عمل inhibition للـhypothalamus و
+
+456
+00:31:09,250 --> 00:31:14,900
+الانتيرويوب أوبهذا القدر نقوم انتهينا من ال
+
+457
+00:31:14,900 --> 00:31:18,720
+chapter الأول ان شاء الله على أمل أن نستكمل في
+
+458
+00:31:18,720 --> 00:31:23,060
+المحاضرات القادمة بأم الله، دومتم في حفظ الله
+
+459
+00:31:23,060 --> 00:31:24,280
+وريعاك
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/dsOa0-DLeoA.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/dsOa0-DLeoA.srt
new file mode 100644
index 0000000000000000000000000000000000000000..a77781c6f4ff2f438a052e0fbcda4a2034ed3149
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/dsOa0-DLeoA.srt
@@ -0,0 +1,3555 @@
+1
+00:00:01,080 --> 00:00:05,080
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:05,080 --> 00:00:10,620
+المرسلين سيدنا محمد وعلى آله وصحبه أجمعين، طلابنا 
+
+3
+00:00:10,620 --> 00:00:14,900
+الأفاضل، نرجو من الله أن تكونوا جميعا بخير وبصحة 
+
+4
+00:00:14,900 --> 00:00:19,860
+جيدة. اليوم سوف ننتقل إلى Chapter جديد يتحدث عن ال
+
+5
+00:00:19,860 --> 00:00:24,260
+embryo transfer and implantation. سوف نتحدث في هذا 
+
+6
+00:00:24,260 --> 00:00:29,020
+الـ Chapter عن آلية نقل الـ Embryo، ما هو الجنين الذي 
+
+7
+00:00:29,020 --> 00:00:34,260
+ينقل؟ كيف يكون تقييم الجنين بناء على الضوابط المعمول 
+
+8
+00:00:34,260 --> 00:00:38,060
+فيها في مختبرات التلقيح الصناعي؟ ما معنى 
+
+9
+00:00:38,060 --> 00:00:41,900
+implantation؟ كيف تحدث عملية الـ Implantation؟
+
+10
+00:00:41,900 --> 00:00:45,000
+بالإضافة إلى الانتقال إلى موضوع الـ
+
+11
+00:00:45,000 --> 00:00:49,820
+Cryopreservation. كان مبدأ مختصرا بسيطا عن آلية 
+
+12
+00:00:49,820 --> 00:00:54,160
+تجميد الأجنة وتجميد البويضات. طبعا هذا الـ Chapter 
+
+13
+00:00:54,160 --> 00:00:57,760
+هيكون هو الـ Chapter الأخير في هذا المساق إن شاء 
+
+14
+00:00:57,760 --> 00:01:03,450
+الله. نبدأ على بركة الله. بداية، عملية الـ Implantation
+
+15
+00:01:03,450 --> 00:01:08,930
+ببساطة جدا هي عبارة عن عملية يتم فيها انغراس 
+
+16
+00:01:08,930 --> 00:01:13,830
+الجنين المنقول بعد عملية التلقيح التي حدثت في 
+
+17
+00:01:13,830 --> 00:01:19,310
+المختبر إلى رحم الأنثى أو رحم السيدة. هذا الانغراس 
+
+18
+00:01:19,310 --> 00:01:23,930
+يؤدي إلى تشابك ما بين الجنين وبين الـ Endometrium 
+
+19
+00:01:23,930 --> 00:01:28,070
+الـ lining الموجودة في رحم السيدة وهي التي تعرف باسم 
+
+20
+00:01:28,370 --> 00:01:33,110
+بطانة الرحم، مما يؤدي في النهاية إلى تكوين الـ Placenta 
+
+21
+00:01:33,110 --> 00:01:36,730
+التي تكون عبارة عن حلقة الوصل ما بين الدورة 
+
+22
+00:01:36,730 --> 00:01:40,690
+الدموية الخاصة بالجنين والدورة الدموية الخاصة 
+
+23
+00:01:40,690 --> 00:01:45,760
+بالأم والتي تكون بمثابة البوابة التي من خلالها يحدث 
+
+24
+00:01:45,760 --> 00:01:49,740
+تبادل المواد الغذائية التي يحتاج إليها الجنين 
+
+25
+00:01:49,740 --> 00:01:54,780
+بالإضافة إلى الـ Oxygen وخلافه. كما نعرف، الـ Placenta 
+
+26
+00:01:54,780 --> 00:01:58,900
+that will provide an interface between growing 
+
+27
+00:01:58,900 --> 00:02:02,120
+fetus and maternal circulation. The human 
+
+28
+00:02:02,120 --> 00:02:06,640
+Endometrium undergo a complex series of organized
+
+29
+00:02:07,790 --> 00:02:12,870
+هذه الـ Endometrium الموجودة في الرحم والتي سميت 
+
+30
+00:02:12,870 --> 00:02:17,750
+بطانة الرحم خلال عملية الـ Ovulation. إذا بدأنا من 
+
+31
+00:02:17,750 --> 00:02:22,690
+البداية مرورا بـ Fertilization إذا كان الأمر طبيعي 
+
+32
+00:02:22,690 --> 00:02:27,690
+تخضع إلى العديد من التغيرات التي تجعل خلايا الـ
+
+33
+00:02:27,690 --> 00:02:33,510
+Endometrium أكثر نموًا، أكثر سماكة، أكثر تقبلًا 
+
+34
+00:02:33,510 --> 00:02:39,370
+لإستقبال الجنين الذي سوف ينغرس في هذه البطانة، مما 
+
+35
+00:02:39,370 --> 00:02:44,110
+يؤدي إلى تكوين الـ Placenta التي تكون ناشئة عن وجود 
+
+36
+00:02:44,110 --> 00:02:49,070
+جنين جديد تم انغراسه في منطقة البطانة. هذه الرحلة، هذه 
+
+37
+00:02:49,070 --> 00:02:53,710
+التغيرات ممكن تكون تغيرات لها علاقة بكمية Blood 
+
+38
+00:02:53,710 --> 00:02:57,390
+Supply التي تصل إلى هذه المنطقة، كمية الـ Proteins 
+
+39
+00:02:57,390 --> 00:03:01,410
+التي تفرز، كمية الـ Transporter Material أو الـ 
+
+40
+00:03:01,410 --> 00:03:04,590
+Transporter Protein التي تبدأ في الهجرة إلى هذا 
+
+41
+00:03:04,590 --> 00:03:09,630
+المكان بالإضافة إلى كمية الهرمونات التي تفرز بحدد 
+
+42
+00:03:09,630 --> 00:03:14,510
+معين من أجل المساهمة في بناء بطانة الرحم ومن أجل 
+
+43
+00:03:14,510 --> 00:03:18,230
+المساهمة في إنجاح عملية الـ Implantation. فبالتالي، 
+
+44
+00:03:18,230 --> 00:03:23,870
+هذه العملية عملية مهمة جدا، عملية نمو بطانة الرحم. 
+
+45
+00:03:23,870 --> 00:03:26,970
+فبالتالي، عملية الانغراس أو عملية الـ Implantation 
+
+46
+00:03:27,220 --> 00:03:32,520
+ليس عملية عشوائية تحدث بسبب فعل واحد أو حدث واحد 
+
+47
+00:03:32,520 --> 00:03:37,100
+إنما هي عبارة عن أحداث متراكمة تؤدي في النهاية إلى 
+
+48
+00:03:37,100 --> 00:03:41,320
+حدوث الـ Implantation in a human during normal 
+
+49
+00:03:41,320 --> 00:03:45,060
+cycle. For example, the Embryo will be enter in the
+
+50
+00:03:45,060 --> 00:03:49,580
+uterine cavity in the four day after Ovulation. في 
+
+51
+00:03:49,580 --> 00:03:53,330
+الوضع الطبيعي، إذا صار عندي Fertilization طبيعي
+
+52
+00:03:53,330 --> 00:03:57,450
+المفروض الـ Embryo إذا تم تلقيحه بشكل طبيعي في قناة 
+
+53
+00:03:57,450 --> 00:04:02,010
+Fallopian Tube هيصل إلى الرحم بعد أربع أيام من 
+
+54
+00:04:02,010 --> 00:04:06,750
+عملية الـ Ovulation. عشان كده حكينا إن البويضة 
+
+55
+00:04:06,750 --> 00:04:11,430
+تستغرق ثلاثة أيام كحد أقصى علشان تقطع منطقة الـ 
+
+56
+00:04:11,430 --> 00:04:16,730
+Fallopian Tube وصولا إلى الـ Uterus. وعشان كده حكينا 
+
+57
+00:04:16,730 --> 00:04:22,120
+إنه عملية إرجاع الأجنة في عملية الحقن المجهري تحدث 
+
+58
+00:04:22,120 --> 00:04:27,140
+بعد ثلاثة أيام كحد أدنى أو خمسة أيام كحد أقصى. إذا 
+
+59
+00:04:27,140 --> 00:04:30,540
+بتتذكر اللغة اللي حكينا عن الـ PGD كانت بيصير 
+
+60
+00:04:30,540 --> 00:04:35,580
+Embryo Transfer ال
+
+61
+00:04:35,580 --> 00:04:38,600
+Endometrium become receptive
+
+62
+00:04:41,190 --> 00:04:47,430
+أقل من 6 أيام بعد الـ Ovulation ويبقى مستمع لـ 4 أيام 
+
+63
+00:04:47,430 --> 00:04:54,730
+في سيكل 22-24، أي دورة شهرية بيولوجية منتظمة عند السيدة 
+
+64
+00:04:54,730 --> 00:04:59,890
+معناه أن الـ Endometrium هتكون قابلة لاستقبال وقادرة 
+
+65
+00:04:59,890 --> 00:05:03,010
+على استقبال الـ Blastocyst وهي عبارة عن 
+
+66
+00:05:03,010 --> 00:05:06,050
+الـ Embryo بعد ما اتحول من مورولا إلى بلاستوسيست 
+
+67
+00:05:06,050 --> 00:05:13,320
+خلال 6 أيام على الأقل بعد الـ Ovulation بينما تبقى 
+
+68
+00:05:13,320 --> 00:05:17,160
+بعد 6 أيام قادرة على استقبال الجنين حتى 4 أيام،
+
+69
+00:05:17,160 --> 00:05:21,320
+يعني بمعنى آخر تستطيع الـ Endometrium أن تحتفظ 
+
+70
+00:05:21,320 --> 00:05:28,080
+بقابليتها لاستقبال الجنين من 6 إلى 4 أيام، Total
+
+71
+00:05:28,080 --> 00:05:32,650
+عشرة أيام من لحظة الـ Ovulation. عشان كده حكينا إنه في 
+
+72
+00:05:32,650 --> 00:05:36,950
+الـ IVF أو الـ IVF عملية الـ Embryo Transfer ممكن تحدث 
+
+73
+00:05:36,950 --> 00:05:39,990
+في اليوم الثاني والثالث والرابع والخامس والسادس. طبعا هذا إيش بتحكم فيه؟ بتحكم عدد الخلايا 
+
+74
+00:05:39,990 --> 00:05:44,270
+اللي انقسمت داخل الجنين، متى وصلت إلى مرحلة الـ
+
+75
+00:05:44,270 --> 00:05:48,230
+Blastocyst؟ هل تحتاج إلى عمل PGD ولا لأ؟ ما هي 
+
+76
+00:05:48,230 --> 00:05:53,150
+طبيعة الفحوصات الوراثية التي سوف تحدث على هذا 
+
+77
+00:05:53,150 --> 00:05:56,770
+الجنين؟ هل تستغرق وقت طويل؟ يومين، ثلاثة؟ فبالتالي 
+
+78
+00:05:56,770 --> 00:06:00,750
+أنا هنتظر نتيجة ظهور الـ PGD as genetic testing 
+
+79
+00:06:00,750 --> 00:06:06,930
+وبناء عليه أقرر أرجع أي جنين. عشان كده ممكن أرجع 
+
+80
+00:06:06,930 --> 00:06:10,270
+الجنين في اليوم الخامس، في اليوم السادس. فسبحان 
+
+81
+00:06:10,270 --> 00:06:13,090
+الله أن الـ Endometrium لها قابلية أن تستقبل جنين
+
+82
+00:06:13,090 --> 00:06:16,710
+لمدة ستة أيام، ستة أيام بالضبط بعد الـ Ovulation 
+
+83
+00:06:16,710 --> 00:06:20,170
+وأضيف عليهم كمان أربعة أيام. أضيف عليهم كمان أربعة
+
+84
+00:06:24,530 --> 00:06:27,390
+أيام. When Implantation does not occur، ما في 
+
+85
+00:06:27,390 --> 00:06:30,610
+Implantation، صار Fertilization وما في Implantation، 
+
+86
+00:06:30,610 --> 00:06:34,850
+ما صار Fertilization، معناه إنه خلاص الـ Endometrium 
+
+87
+00:06:34,850 --> 00:06:38,250
+هتبدأ عملية الـ Destruction و we are removing as
+
+88
+00:06:38,250 --> 00:06:42,330
+bleeding تحت مصطلح الدورة أو الـ Menstrual Cycle.
+
+89
+00:06:42,330 --> 00:06:46,390
+هذا اللي بيصير في وضعه الطبيعي. طيب السؤال، هل الـ
+
+90
+00:06:46,390 --> 00:06:50,430
+Implantation تحدث بشكل عابر؟ هل الـ Implantation 
+
+91
+00:06:50,430 --> 00:06:55,180
+تحدث بفعل حدث واحد أم أحداث متتالية؟ To achieve
+
+92
+00:06:55,180 --> 00:06:58,900
+successful Implantation, the Uterus should undergo
+
+93
+00:06:58,900 --> 00:07:02,660
+structural and functional remodeling. يعني معناها 
+
+94
+00:07:02,660 --> 00:07:07,020
+إنه لازم أنا أهيئ الرحم للتغيرات الفسيولوجية 
+
+95
+00:07:07,020 --> 00:07:11,710
+والوظيفية المطلوبة. التمدد مثلًا، تسارع عملية انقسام 
+
+96
+00:07:11,710 --> 00:07:15,410
+الخلايا، زيادة الـ Blood Supply، زيادة مستوى 
+
+97
+00:07:15,410 --> 00:07:18,650
+الهرمونات المعينة زي الـ Progesterone. عشان كده 
+
+98
+00:07:18,650 --> 00:07:23,310
+حكينا بعد الـ ET، بعد عملية الـ Embryo Transfer في 
+
+99
+00:07:23,310 --> 00:07:26,530
+الـ Agonist والـ Antagonist، الزوجة أو المرأة 
+
+100
+00:07:26,530 --> 00:07:30,010
+تُعطى Progesterone عن طريق الـ Cervical من أجل 
+
+101
+00:07:30,010 --> 00:07:35,070
+تحفيز زيادة أو من أجل تحفيز وزيادة معدل نمو 
+
+102
+00:07:35,070 --> 00:07:39,430
+الخلايا المبطنة للرحم، من أجل تثبيت الجنين، ومن أجل 
+
+103
+00:07:39,430 --> 00:07:43,850
+المساعدة في زيادة فرصة الـ Implantation أثناء 
+
+104
+00:07:43,850 --> 00:07:48,790
+عملية تاريجية الأجنة الملقحة أو التي خلقت.. 
+
+105
+00:07:48,790 --> 00:07:51,610
+خلينا نسميها.. أو التي نتجت من التلقيح الصناعي 
+
+106
+00:07:51,610 --> 00:07:55,970
+في المختبر. الاستروجين والبروجسترون هما الهرمون 
+
+107
+00:07:55,970 --> 00:08:02,990
+المعروف. هذا الهرمون سيفعل point and rule in this 
+
+108
+00:08:02,990 --> 00:08:07,090
+step or in this function وهي structural and 
+
+109
+00:08:07,090 --> 00:08:11,210
+functional remodeling of uterus. فبالتالي عند
+
+110
+00:08:11,210 --> 00:08:14,170
+الاستروجين والبروجسترون هما أشهر الهرمونات 
+
+111
+00:08:14,170 --> 00:08:19,330
+التي تلعب دورًا مهمًا وأساسيًا وفعالًا لعملية تهيئة 
+
+112
+00:08:19,330 --> 00:08:24,550
+الرحم لاستقبال الجنين. البروجسترون أيضًا يلعب دورًا
+
+113
+00:08:24,550 --> 00:08:27,950
+رئيسيًا في عملية إنجاح الـ Implantation من خلال 
+
+114
+00:08:27,950 --> 00:08:33,730
+تدعيم وزيادة معدل نمو الأجنة، بالإضافة إلى زيادة أو 
+
+115
+00:08:33,730 --> 00:08:38,370
+تدام نمو وتطور الجنين لكي يصل إلى المرحلة 
+
+116
+00:08:38,370 --> 00:08:42,050
+المقبولة التي تساهم في عملية الـ Implantation. في ال
+
+117
+00:08:42,050 --> 00:08:44,550
+Follicular Phase is under influence of rising
+
+118
+00:08:44,550 --> 00:08:48,010
+Estrogen level due to growing Ovarian Follicle. إذا 
+
+119
+00:08:48,010 --> 00:08:51,450
+بنرجع بالذاكرة للـ Chapter 2 قلنا فيه عندي.. أو الـ 
+
+120
+00:08:51,450 --> 00:08:53,710
+Chapter 2 فيه عندي الـ Follicular Phase والـ 
+
+121
+00:08:53,710 --> 00:08:56,430
+Follicular Phase هو عبارة عن الطور الذي تبدأ 
+
+122
+00:08:56,430 --> 00:09:00,670
+البويضة في النضوج، فلوكيلة بالنضوج يعني البويضة 
+
+123
+00:09:00,670 --> 00:09:04,910
+بالنضوج بداخلها، نضوج البويضة معناه إفراز هرمون 
+
+124
+00:09:04,910 --> 00:09:10,190
+الاستروجين الذي يرسل إشارة إلى الرحم وخلايا 
+
+125
+00:09:10,190 --> 00:09:12,790
+الرحم، أي الخلايا المبطنة للرحم التي سميتها 
+
+126
+00:09:12,790 --> 00:09:17,910
+Endometrium، من أجل البدء في الانقسام والتضاعف 
+
+127
+00:09:17,910 --> 00:09:24,430
+لتهيئة الرحم لاستقبال بويضة مخصبة إن حدث التخصيب.
+
+128
+00:09:24,430 --> 00:09:29,230
+لذلك يقول إن الاستروجين أيضًا دورهم خلال 
+
+129
+00:09:29,230 --> 00:09:34,150
+الـ Follicular Phase لتو Proliferation of 
+
+130
+00:09:34,150 --> 00:09:38,230
+Epithelium، Stroma، and Vascular Endothelium to
+
+131
+00:09:38,230 --> 00:09:42,800
+cause regeneration of the Endometrium. عرفت إيه وشو 
+
+132
+00:09:42,800 --> 00:09:46,720
+وظيفة الاستروجين، وأين يفرز الاستروجين؟ اعمل 
+
+133
+00:09:46,720 --> 00:09:50,260
+Flashback للـ Chapter الثاني أو الثالث، هنعرف إن 
+
+134
+00:09:50,260 --> 00:09:54,460
+الاستروجين يفرز من البويضة أو من الـ Follicle التي 
+
+135
+00:09:54,460 --> 00:09:59,020
+تبدأ بالنضوج وكل ما زاد عدد البويضات الناضجة، زاد 
+
+136
+00:09:59,020 --> 00:10:02,640
+مستوى الاستروجين. عشان كده قلنا إن الاستروجين 
+
+137
+00:10:02,640 --> 00:10:06,780
+يعتبر أحد الـ Indicators التي تستخدم للتعرف على عدد 
+
+138
+00:10:06,780 --> 00:10:11,630
+البويضات التي قد تنضج مستقبلاً. ما هو وظيفته في عملية 
+
+139
+00:10:11,630 --> 00:10:15,290
+الـ Implantation؟ إنه يرسل إشارة إلى الـ Uterus. 
+
+141
+00:10:15,290 --> 00:10:19,930
+إنه تبدأ خلايا بطانة الرحم تنمو وتضاعف وتتكثر من
+
+142
+00:10:19,930 --> 00:10:25,430
+أجل تهيئ الرحم لاستقبال جنين جديد أو بويضة مخصبة
+
+143
+00:10:25,430 --> 00:10:33,530
+الـ Estrogen can induce Uterine طبعا الـ Estrogen
+
+144
+00:10:33,530 --> 00:10:38,330
+أيضا بلعب دور في زيادة قابلية الرحم أن يستقبل هذه
+
+145
+00:10:38,330 --> 00:10:45,570
+البويضة من خلال حثّها على الالتصاق من خلال زيادة معدل
+
+146
+00:10:45,570 --> 00:10:49,750
+انقسام الخلايا زيادة blood supply remaining open for
+
+147
+00:10:49,750 --> 00:10:54,730
+extended period at lower estrogen level يعني مش بس
+
+148
+00:10:54,730 --> 00:10:59,430
+أنه بيزيد معدل استقبال أو معدل نمو و تكاثر
+
+149
+00:10:59,430 --> 00:11:03,390
+الخلايا لأ  أنه بيعمل extension لعدد الأيام التي 
+
+150
+00:11:03,390 --> 00:11:07,450
+تسمح لبطانة الرحم باستقبال الجنين اللي احنا قلناها 
+
+151
+00:11:07,450 --> 00:11:11,890
+أربع أيام إضافية رغم أنه فيه ستة أيام أربع أيام
+
+152
+00:11:11,890 --> 00:11:14,370
+إضافية بفعل الـ E2
+
+153
+00:11:16,840 --> 00:11:22,620
+أيضًا بالنسبة للأستروجين level is improved when
+
+154
+00:11:22,620 --> 00:11:24,860
+estrogen levels are decreased during pre
+
+155
+00:11:24,860 --> 00:11:27,960
+-implantation period and patients undergo in vitro
+
+156
+00:11:27,960 --> 00:11:32,480
+fertilization مهم جدًا من أجل زيادة وتحسين قدرة
+
+157
+00:11:32,480 --> 00:11:36,820
+الرحم على استقبال البويضة المخصبة لإيصال reduction
+
+158
+00:11:36,820 --> 00:11:41,180
+للأستروجين مايعني reduction للأستروجين؟ معنى
+
+159
+00:11:41,180 --> 00:11:44,200
+reduction للأستروجين يعني مستوى الأستروجين يقل
+
+160
+00:11:44,410 --> 00:11:50,090
+معناه الجسم بيفهم تلقائيًا أن الفوليكلر انفجرت وصار
+
+161
+00:11:50,090 --> 00:11:54,530
+ovulation يعني البويضة قد تكون قُصّبت فبالتالي
+
+162
+00:11:54,530 --> 00:11:57,190
+عملية الـFollicular phase وعملية الـ ovulation
+
+163
+00:11:57,190 --> 00:12:01,410
+انتهت منها انتهى الجسم منها يعني بتبدأ بمرحلة
+
+164
+00:12:01,410 --> 00:12:05,170
+جديدة وهي استقبال الجنين تحت مصطلح implantation
+
+165
+00:12:05,170 --> 00:12:08,310
+فبالتالي الـ استروجين لازم يقل في هذه الفترة وإلا
+
+166
+00:12:08,310 --> 00:12:13,670
+إذا ظلّ مرتفع معناه لسه ما صار في عندي الوصول
+
+167
+00:12:13,670 --> 00:12:16,710
+لدرجة نضوج البويضة معناه ما صار في عندي
+
+168
+00:12:16,710 --> 00:12:28,610
+ovulation لأ بالراحة التي كانت
+
+169
+00:12:28,610 --> 00:12:34,070
+مفروض تكون صار لها operation حاليًا الـ early embryo
+
+170
+00:12:34,070 --> 00:12:38,430
+entered the uterine cavity as morula and become 32
+
+171
+00:12:38,430 --> 00:12:43,810
+to 265
+
+172
+00:12:43,810 --> 00:12:48,250
+65 cell blastocyst before implantation بمعنى آخر أن
+
+173
+00:12:48,250 --> 00:12:53,170
+الـ embryo ممكن يصل و يدخل تجويف الرحم يا إما على
+
+174
+00:12:53,170 --> 00:12:57,970
+شكل موريلا أو على شكل بلاستوسيت عدد خلاياها تصل إلى
+
+175
+00:12:57,970 --> 00:13:06,510
+2256 خلية موريلا أو بلاستوسيت والأكثر بلاستوسيت
+
+176
+00:13:06,510 --> 00:13:09,230
+Implantation beginning with the loss of zona
+
+177
+00:13:09,230 --> 00:13:12,750
+pellucida or hatching as we know about one to
+
+178
+00:13:12,750 --> 00:13:16,290
+three day after موريلا entered the uterine Cavity
+
+179
+00:13:16,290 --> 00:13:19,490
+in the preparation of attachment يعني عملية ال
+
+180
+00:13:19,490 --> 00:13:23,850
+implantation تبدأ بدخول الجنين في مرحلة الموريلا
+
+181
+00:13:23,850 --> 00:13:32,650
+إلى ال cavity الخاص برحم السيدة ثم تبدأ ال zona
+
+182
+00:13:32,650 --> 00:13:39,310
+pellucida باتهتك أو تنقسم أو تتقشر أو تُزال هذا
+
+183
+00:13:39,310 --> 00:13:43,670
+تقريبًا بياخد يوم إلى ثلاثة أيام بعد دخول الموريلا
+
+184
+00:13:43,670 --> 00:13:48,250
+الـ uterine cavity بعد كده بتبدأ عملية ال attachment
+
+185
+00:13:48,250 --> 00:13:52,190
+مع الـ endometrium يعني ثلاث نقاط أساسية دخول
+
+186
+00:13:52,190 --> 00:13:58,930
+الموريلا أو الـ embryo كـ موريلا لتجويف الرحم
+
+187
+00:13:58,930 --> 00:14:03,570
+إزالة وتهتك الـ zona pellucida والبدء في عملية ال
+
+188
+00:14:03,570 --> 00:14:06,450
+attachment مع الـ endometrium عشان كده قسموا الـ
+
+189
+00:14:06,450 --> 00:14:09,950
+Implantation إلى ثلاث مقاطع أو ثلاث أطوار الطور
+
+190
+00:14:09,950 --> 00:14:13,690
+الأول بيسموه Opposition والطور الثاني بيسموه
+
+191
+00:14:13,690 --> 00:14:16,830
+Adhesion والطور الثالث بيسموه Invasion الـ
+
+192
+00:14:16,830 --> 00:14:19,890
+Opposition بيصير فيه عندي blastocyst contact the
+
+193
+00:14:19,890 --> 00:14:22,290
+implantation site of the endometrium يعني الـ
+
+194
+00:14:22,290 --> 00:14:25,290
+blastocyst بتتصل بالمكان اللي المفروض بيصير فيه
+
+195
+00:14:25,290 --> 00:14:28,010
+Implantation بيسموه Opposition بعدين الـ Adhesion
+
+196
+00:14:28,010 --> 00:14:33,480
+أن الـ trophoblast cells of the blastocyst تتصل مع
+
+197
+00:14:33,480 --> 00:14:36,880
+الـ endometrium بعدين بيصير عندي invasion وهي
+
+198
+00:14:36,880 --> 00:14:41,040
+عبارة عن الانغماس أو الانغراس أن البلاستوسيت جميع
+
+199
+00:14:41,040 --> 00:14:45,500
+خلاياها تبدأ تتشابك مع الـ endometrium وتصبح جزء
+
+200
+00:14:45,500 --> 00:14:48,980
+لا يتجزأ منها هل بنسميها invasion انغراس
+
+201
+00:14:48,980 --> 00:14:50,820
+opposition
+
+202
+00:14:52,700 --> 00:14:55,160
+and adhesion implantation beginning with the
+
+203
+00:14:55,160 --> 00:14:57,900
+apposition of the blastocyst at the uterine and
+
+204
+00:14:57,900 --> 00:15:01,040
+epithelium generally about two to four days after
+
+205
+00:15:01,040 --> 00:15:04,920
+morula entered the uterine cavity يعني بيقول لي أن
+
+206
+00:15:04,920 --> 00:15:08,220
+الـ opposition والـ adhesion الخاصة بالـ
+
+207
+00:15:08,220 --> 00:15:12,600
+implantation على أساس أنهم أول حدثين بتبدأ من
+
+208
+00:15:12,600 --> 00:15:16,080
+اليوم الثاني إلى اليوم الرابع بعد يعني بعد يومين
+
+209
+00:15:16,080 --> 00:15:20,840
+إلى أربعة أيام بعد دخول الموريلا إلى تجويف الرحم الـ
+
+210
+00:15:20,840 --> 00:15:24,700
+Implantation is considered العلماء صنفوا الـ
+
+211
+00:15:24,700 --> 00:15:30,040
+Implantation على إنها ظاهرة تسمى Pro-inflammatory
+
+212
+00:15:30,040 --> 00:15:33,870
+reaction طب ليه سموها بهذا الشكل؟ لأنه بيصير عندي
+
+213
+00:15:33,870 --> 00:15:39,090
+vasovascular permeability is markedly increased at
+
+214
+00:15:39,090 --> 00:15:42,830
+the attachment site mediated by cyclooxygenase
+
+215
+00:15:42,830 --> 00:15:46,090
+derivative prostaglandin لأنه بيصير عندي شغلة شغلتين
+
+216
+00:15:46,090 --> 00:15:49,670
+الأولى زيادة النفاذية الخاصة بالأوعية الدموية مما
+
+217
+00:15:49,670 --> 00:15:54,170
+يؤدي إلى زيادة ضغط الدم للمكان الذي انغرص فيه
+
+218
+00:15:54,170 --> 00:15:58,830
+الجنين الشغلة الثانية إفراز بعض المكونات الأساسية
+
+219
+00:15:58,830 --> 00:16:02,750
+التي تلعب دور كبير جدا التي تعمل على زيادة الضغط
+
+220
+00:16:02,750 --> 00:16:05,550
+قدامها و زيادة الدورة الدموية زي الـ prostaglandin
+
+221
+00:16:05,550 --> 00:16:10,010
+اللي يسمونه coax prostaglandin أو cyclooxygenase
+
+222
+00:16:12,810 --> 00:16:15,850
+Prostaglandin E2 هذا الكلام أخذناه تقريبًا في
+
+223
+00:16:15,850 --> 00:16:19,710
+الشابتر الأول والشابتر الثاني عرّجنا عليه بشكل بسيط
+
+224
+00:16:19,710 --> 00:16:23,350
+أنه يقول بروستاجلاندين E2 is increased in the
+
+225
+00:16:23,350 --> 00:16:27,310
+luminal epithelium and the underlying stroma at
+
+226
+00:16:27,310 --> 00:16:30,230
+the human implantation site يعني بيبدأ يزيد في
+
+227
+00:16:30,230 --> 00:16:33,890
+المنطقة اللي صار فيها implantation those indicate
+
+228
+00:16:33,890 --> 00:16:36,770
+its role in the attached and localized
+
+229
+00:16:36,770 --> 00:16:40,520
+endometrium vascular permeability يعني
+
+230
+00:16:40,520 --> 00:16:45,340
+الـ prostaglandin E2 أول زياداته تكمن في المنطقة
+
+231
+00:16:45,340 --> 00:16:48,600
+اللي صار فيها attachment وإن البلاستوسيت عملت 
+
+232
+00:16:48,600 --> 00:16:52,420
+attachment مع الـ endometrium يبدأ البروستاجلاندين
+
+233
+00:16:52,420 --> 00:16:56,420
+بالانفراز والخروج في هذه المنطقة طب إيش وظيفته؟
+
+234
+00:16:56,420 --> 00:17:00,140
+وظيفته بشكل أساسي Indicating its role in the
+
+235
+00:17:00,140 --> 00:17:03,340
+attachment and localized endometrium vascular
+
+236
+00:17:03,340 --> 00:17:07,900
+permeability بحدد مكان الـ attachment ما بين
+
+237
+00:17:07,900 --> 00:17:11,880
+البلاستوسيت والـ endometrium مما يؤدي إلى زيادة
+
+238
+00:17:11,880 --> 00:17:15,960
+النفاذية الدموية لهذه المنطقة يعني زيادة الدور
+
+239
+00:17:15,960 --> 00:17:18,600
+الدموية وضخ الدم في هذه المنطقة اللي صار فيها
+
+240
+00:17:18,600 --> 00:17:23,400
+attachment during a position process, the placenta
+
+241
+00:17:23,400 --> 00:17:27,480
+differentiates into inner cell mass embryo and trophoectoderm
+
+242
+00:17:27,480 --> 00:17:30,770
+placenta خلال هذه العملية، وهي الخطوة الأولى من
+
+243
+00:17:30,770 --> 00:17:34,370
+عملية الـ Implantation لـ blastocyst بتم فيها
+
+244
+00:17:34,370 --> 00:17:37,730
+عملية التمايز إلى two parts الـ part الداخل اللي
+
+245
+00:17:37,730 --> 00:17:40,750
+بيسميها inner cell mass وهي عبارة عن جنين والـ
+
+246
+00:17:40,750 --> 00:17:44,250
+part الخارجي وهي trophoectoderm اللي بيسميها
+
+247
+00:17:44,250 --> 00:17:48,770
+placenta اللي بتكوّن الـ placenta فيما بعد طبعا بعد
+
+248
+00:17:48,770 --> 00:17:52,830
+الحدث الأول الـ opposition بيصير الحدث الثاني وهو ال
+
+249
+00:17:52,830 --> 00:17:56,630
+adhesion stage والـ adhesion stage في الغالب in
+
+250
+00:17:56,630 --> 00:17:59,270
+which the association of trophoblast and the
+
+251
+00:17:59,270 --> 00:18:02,430
+luminal epithelia is strong enough to resist
+
+252
+00:18:02,430 --> 00:18:07,610
+dislodgement of blastocyst by flushing the
+
+253
+00:18:07,610 --> 00:18:11,790
+uterine lumina بمعنى آخر أن هذا الـ stage اللي سمّيته
+
+254
+00:18:11,790 --> 00:18:16,830
+adhesion مهم جدًا لأنه بيلعب دور كبير جدا في تثبيت
+
+255
+00:18:17,360 --> 00:18:21,300
+الـ embryo في هذا المكان ومنع الـ embryo من عملية
+
+256
+00:18:21,300 --> 00:18:24,760
+تغيير مكانه يعني بيخلّيه resistant for this
+
+257
+00:18:24,760 --> 00:18:28,700
+location ما بيخليه يغير مكانه لأنه إذا صار
+
+258
+00:18:28,700 --> 00:18:31,760
+adhesion معناه الخطوة الثانية الـ invasion مهمة جدا
+
+259
+00:18:31,760 --> 00:18:37,040
+حتصير بدون adhesion معناه مافي عندي invasion طبعا
+
+260
+00:18:37,040 --> 00:18:41,380
+هذا الـ stage اللي سمّيته adhesion بياخد ما يقارب من
+
+261
+00:18:41,380 --> 00:18:48,260
+20 إلى 21 يومًا مهم جدا في زيادة استمرارية تدفق
+
+262
+00:18:48,260 --> 00:18:51,720
+الدم إلى المكان اللي صار فيه attachment بعدين
+
+263
+00:18:51,720 --> 00:18:54,860
+بيجي بعد الـ adhesion مرحلة أخرى وهي الـ invasion
+
+264
+00:18:54,860 --> 00:19:00,340
+التي يتم من خلالها غوص الـ embryo أو blastocyst
+
+265
+00:19:00,340 --> 00:19:04,580
+بشكل شبه كامل داخل الـ endometrium وتثبيتها بشكل
+
+266
+00:19:04,580 --> 00:19:09,540
+كبير جدا والبداية في تكوين الـ placenta
+
+267
+00:19:12,110 --> 00:19:17,450
+هذا بالنسبة إلى مراحل عملية الـ Implantation دعونا
+
+268
+00:19:17,450 --> 00:19:20,850
+ننتقل إلى موضوع جديد وهو الـ Embryo Transfer لم
+
+269
+00:19:20,850 --> 00:19:24,650
+أكن مسموح أن أعمل Embryo Transfer يعني 3 Embryos
+
+270
+00:19:24,650 --> 00:19:28,230
+بعد الحقن المجهري ولا 2 ولا 4 ولا 5 في الغالب
+
+271
+00:19:28,230 --> 00:19:34,010
+معظم المراكز ثبتت أن أنا أعمل Transfer لثلاثة 2
+
+272
+00:19:34,010 --> 00:19:37,370
+Embryos ولكن يعتمد هذا على الحالة ممكن أعمل
+
+273
+00:19:37,370 --> 00:19:42,150
+Transfer لـ 1 Embryo أو 3 Embryos مع بعض في الدول
+
+274
+00:19:42,150 --> 00:19:44,750
+الأوروبية القانون واحد Embryo مافيش أكتر و كده بعض
+
+275
+00:19:44,750 --> 00:19:49,370
+الحالات بيرجع اتنين بموافقة خطية من المريض ولكن
+
+276
+00:19:49,370 --> 00:19:53,890
+قانونًا one embryo embryo transfer can be performed
+
+277
+00:19:53,890 --> 00:19:57,990
+in the day three after cleavage or after
+
+278
+00:19:57,990 --> 00:20:03,130
+fertilization or day five in the blastocyst stage
+
+279
+00:20:03,130 --> 00:20:07,070
+after fertilization وهذا أو after egg collection
+
+280
+00:20:07,070 --> 00:20:09,950
+and fertilization يعني أنا مسموح ليه ك
+
+281
+00:20:09,950 --> 00:20:14,190
+embryologist أرجع الأجنة في اليوم الثاني أو اليوم 
+
+282
+00:20:14,190 --> 00:20:18,910
+الخامس أو اليوم السادس طبعاً لها قوانين معينة لها
+
+283
+00:20:18,910 --> 00:20:22,150
+ضوابط معينة ولكن in general اليوم الثالث بعض
+
+284
+00:20:22,150 --> 00:20:25,970
+الأحيان اليوم الخامس في الـ United States على سبيل
+
+285
+00:20:25,970 --> 00:20:29,790
+المثال في protocol أنه أنا ما أرجع الجنين إلا في
+
+286
+00:20:29,790 --> 00:20:32,730
+اليوم الخامس يعني لما نصل لمرحلة الـ blastocyst plus sixth
+
+287
+00:20:32,730 --> 00:20:38,250
+stage في اليوم الثالث مسموح لي أرجع فقط الـ embryo
+
+288
+00:20:38,250 --> 00:20:41,910
+اللي هو عبارة عن good quality embryo or generally
+
+289
+00:20:41,910 --> 00:20:45,810
+between six to eight cells شو يعني good quality؟
+
+290
+00:20:45,810 --> 00:20:50,350
+هنعرفها كمان شوية ولكن بقول في اليوم الثالث الجنين
+
+291
+00:20:50,350 --> 00:20:54,720
+دائماً بيكون من ست خلايا لثمان خلايا طالما الجنين وصل
+
+292
+00:20:54,720 --> 00:20:59,900
+لـ 6 خلايا أو 8 خلايا مسموح لي أرجع رجع جنين إلى رحم
+
+293
+00:20:59,900 --> 00:21:03,700
+السيدة أو اثنين أو ثلاثة بناء على اعتبارات معينة
+
+294
+00:21:03,700 --> 00:21:08,830
+ولكن بعض المراكز ثبتت على اليوم الخامس الفرصة
+
+295
+00:21:08,830 --> 00:21:13,430
+للمنتظر حتى اليوم الخامس هي أنها تقدم وقت إضافي
+
+296
+00:21:13,430 --> 00:21:18,410
+لتختار الـ protocol بقيمة أفضل لأن فقط 50%-60% من
+
+297
+00:21:18,410 --> 00:21:20,850
+الـ embryo يمتلك القدرة على التطور إلى الـ blastocyst
+
+298
+00:21:20,850 --> 00:21:25,450
+ومن ثم أقل من الـ embryo مستحيل للتبريد
+
+299
+00:21:25,450 --> 00:21:29,450
+والتحريك ليه سببته على اليوم الخامس؟ بقول لك لأن
+
+300
+00:21:29,450 --> 00:21:32,830
+التأخر في عملية إرجاع الأجنّة وبقاء الجنين في 
+
+301
+00:21:32,830 --> 00:21:37,460
+المختبر في الظروف المناسبة داخل الـ incubator يسمح 
+
+302
+00:21:37,460 --> 00:21:43,100
+للجنين بالنمو والتضاعف بشكل مناسب بشكل ملحوظ بشكل
+
+303
+00:21:43,100 --> 00:21:49,480
+يعطي له أفضلية للبقاء إن تم ترجعه أضيف إلى ذلك أن
+
+304
+00:21:49,480 --> 00:21:54,620
+تأخير عملية الترجيع تعطيني information أكثر عن كيف
+
+305
+00:21:55,020 --> 00:21:58,520
+يتحرك هذا الجنين أو كيف ينمو هذا الجنين أو كيف
+
+306
+00:21:58,520 --> 00:22:03,840
+تنقسم خلايا هذا الجنين إضافة إلى أنها تسمح لي بعمل
+
+307
+00:22:03,840 --> 00:22:08,060
+فحوصات المطلوبة من أجل اختيار أفضل جنين من أجل
+
+308
+00:22:08,060 --> 00:22:13,100
+إرجاع من أجل إرجاع أيضا إن في بعض الأحيان بكون عندي
+
+309
+00:22:13,100 --> 00:22:18,310
+عشرة أجنة فأنا ألجأ إلى تخزين بعض الأجنة مش منطق
+
+310
+00:22:18,310 --> 00:22:22,090
+أرجع عشرة أجنة أرجع ثلاثة اثنين طب والباقي أرميهم
+
+311
+00:22:22,090 --> 00:22:25,690
+أعملهم إتلاف أعملهم removing لأ بعمله بحاجة اسمها 
+
+312
+00:22:25,690 --> 00:22:31,510
+freezing أو cryopreservation الحفظ بالتبريد طب أنا 
+
+313
+00:22:31,510 --> 00:22:34,850
+مين أفضل أعمله cryopreservation و freezing وهو في
+
+314
+00:22:34,850 --> 00:22:39,270
+اليوم الثاني أو الثالث أو بعد خمس أيام كل ما زادت
+
+315
+00:22:39,270 --> 00:22:43,540
+فترة الانتظار كل ما كان نتيجة الـ freezing أفضل لأن 
+
+316
+00:22:43,540 --> 00:22:48,380
+بكون الجنين كده خلاياه شبه استقرت فبالتالي إذا
+
+317
+00:22:48,380 --> 00:22:51,140
+أنا عملت freezing في اليوم الخامس أو اليوم السادس
+
+318
+00:22:51,140 --> 00:22:54,440
+أفضل من إني أعمل freezing للأجنة أو للبواية ..
+
+319
+00:22:54,440 --> 00:22:58,460
+للأجنة عفواً في اليوم الثاني أو الثالث لأنه لسه ما
+
+320
+00:22:58,460 --> 00:23:03,960
+استقرت في مرحلة الإنقاذ The recommended number of
+
+321
+00:23:03,960 --> 00:23:07,580
+embryo to transfer is determined by women age and
+
+322
+00:23:07,580 --> 00:23:10,930
+timing of the embryo transfer يعني أنا ..جدش بدأ
+
+323
+00:23:10,930 --> 00:23:13,790
+أرجع embryo هذا يعتمد على سن المرأة والله إذا كانت
+
+324
+00:23:13,790 --> 00:23:17,990
+المرأة كبيرة في العمر يعني بعد الأربعين فرصة
+
+325
+00:23:17,990 --> 00:23:22,090
+الإنجاب إلى كل ما زاد العمر تقل فبالتالي ممكن ألجأ
+
+326
+00:23:22,090 --> 00:23:27,110
+إلى زيادة عدد الـ embryo المرجعة للسيدة لسه شابة في
+
+327
+00:23:27,110 --> 00:23:31,680
+بداية العشرينات مش منطقي أنا لسه عندها فترة زمنية
+
+328
+00:23:31,680 --> 00:23:34,060
+طويلة لإنجاب مرة واثنين وثلاثة وأربع مش منطقي
+
+329
+00:23:34,060 --> 00:23:37,180
+في المرة الأولى أروح وأرجع لثلاثة embryo لأ واحد
+
+330
+00:23:37,180 --> 00:23:41,140
+اثنين maximum فبالتالي اللي يحكم هذه العملية عمر
+
+331
+00:23:41,140 --> 00:23:45,940
+السيدة و quality of embryo يعني أنه على سبيل
+
+332
+00:23:45,940 --> 00:23:50,460
+المثال عندي عشرة بويضات لقحت العشرة بويضات أعطي عشر
+
+333
+00:23:50,460 --> 00:23:54,360
+أجنة في العشرة أجنة ما لقيت إلا اثنين embryo هم
+
+334
+00:23:54,360 --> 00:23:58,180
+اللي انقسموا وهم أفضل embryo اللي باقي مش كويسين
+
+335
+00:23:58,180 --> 00:24:03,350
+ده الفكرة منطق أرجع للاتنين ونخلصنا من هذه القصة
+
+336
+00:24:03,350 --> 00:24:06,550
+لأن ليس منطق أرجع واحد وبعدها أذهب وأعمله
+
+337
+00:24:06,550 --> 00:24:11,350
+freezing لأن ثمانية الباقين ما انقسموا فبالتالي as
+
+338
+00:24:11,350 --> 00:24:16,270
+one chance أرجع الاثنين احتياطاً اثنين ناموا و
+
+339
+00:24:16,270 --> 00:24:19,010
+أصبحوا in block وأنا بياخذ واحد اه وواحد لا كده
+
+340
+00:24:19,010 --> 00:24:24,350
+أنا بكون عندي probability أو chance 50% a serum
+
+341
+00:24:24,350 --> 00:24:29,610
+pregnancy test is performed 11 day after cleavage
+
+342
+00:24:29,610 --> 00:24:34,510
+or embryo transfer 9 day after blastocyst transfer
+
+343
+00:24:34,510 --> 00:24:40,950
+أنا عملت نقل للاجنة ممكن أعمل فحص الـ beta HCG أو
+
+344
+00:24:40,950 --> 00:24:45,490
+فحص الحمل في اليوم رقم 11 من نقل الـ embryo أو في
+
+345
+00:24:45,490 --> 00:24:49,790
+اليوم رقم 9 من نقل الـ blastocyst ومعظمهم بيعملوا
+
+346
+00:24:49,790 --> 00:24:53,770
+في اليوم رقم 9 معظم في اليوم رقم 9 نادر جداً ما
+
+347
+00:24:53,770 --> 00:24:58,240
+يعملوا في اليوم رقم 14 معظم بيعملوا في اليوم رقم 9
+
+348
+00:24:58,240 --> 00:25:01,580
+يعني بمعنى آخر في واحد الشهر صار embryo transfer
+
+349
+00:25:01,580 --> 00:25:05,940
+في عشرة الشهر بتيجي بتعمل أو تسعة الشهر بتيجي بتعمل
+
+350
+00:25:05,940 --> 00:25:10,400
+الـ beta HCG عشان تأخذ احتياطاتها أيضاً طبعاً
+
+351
+00:25:10,400 --> 00:25:14,000
+بيعملوا من الدم مش من البول خصوصاً للسيدات اللي 
+
+352
+00:25:14,000 --> 00:25:19,640
+خضعوا لـ IVF جدول يوضح لي عدد الـ embryo المفضل
+
+353
+00:25:19,640 --> 00:25:24,940
+إرجاعها بناء على العمر إذا كانت السيدة أقل من 35
+
+354
+00:25:24,940 --> 00:25:30,200
+أرجع one embryo the best if no high quality embryo present
+
+355
+00:25:30,200 --> 00:25:33,620
+إذا ما فيش إيش يعني high quality يعني إذا فيه 
+
+356
+00:25:33,620 --> 00:25:36,220
+أنا عندي embryo high quality أرجع واحد ما في عندي
+
+357
+00:25:36,220 --> 00:25:39,440
+high quality أرجع اثنين هذه للسيدة اللي عمرها 35
+
+358
+00:25:39,440 --> 00:25:44,280
+وأقل من 35 لـ 37 إذا في عندي high quality أرجع واحد
+
+359
+00:25:44,280 --> 00:25:48,800
+ما في أرجع اثنين من 38 لـ 40 ما في عندي high quality
+
+360
+00:25:48,800 --> 00:25:54,320
+هرجع اثنين high quality embryo ولكن عمرها 38 إذا 
+
+361
+00:25:54,320 --> 00:25:59,120
+فرصة الإنجاب مستقبلاً بتقل وما بدأت أخضعها لل
+
+362
+00:25:59,120 --> 00:26:03,040
+ovarian stimulation أكثر من مرة فأرجع two embryo
+
+363
+00:26:03,040 --> 00:26:07,200
+عشان أزيد فرصة نجاح الـ IVF والله ما في عندي high
+
+364
+00:26:07,200 --> 00:26:12,660
+quality embryo أرجع ثلاثة عندي عدد الـ age أقل من أربع
+
+365
+00:26:12,660 --> 00:26:15,780
+أربعين وفوق يعني أكبر من أربعين يعني قريباً من ال
+
+366
+00:26:15,780 --> 00:26:20,030
+menopause أرجع خمسة embryo رغم أنه موجود في high
+
+367
+00:26:20,030 --> 00:26:23,250
+quality embryo ما في عندي high quality أيضاً أرجع
+
+368
+00:26:23,250 --> 00:26:27,230
+خمسة embryo شو يعني high quality؟ الـ high quality
+
+369
+00:26:27,230 --> 00:26:33,350
+embryo يعني embryo يحتوي على ست خلايا blastomere
+
+370
+00:26:33,350 --> 00:26:38,490
+أو أكبر ست خلايا blastomere أو أكبر بمعنى آخر عدد
+
+371
+00:26:38,490 --> 00:26:44,530
+الأجنة المرجعة يتناسب تناسباً طردياً مع سن الزوجة أو 
+
+372
+00:26:44,530 --> 00:26:52,010
+الأنثى كلما زاد سنها كلما زاد عدد الأجنة المرجعة
+
+373
+00:26:52,010 --> 00:26:59,310
+طبعاً جدول آخر يوضّح لي شو يعني grade 1 و grade 2 و
+
+374
+00:26:59,310 --> 00:27:03,870
+grade 3 و grade 4 يعني شو يعني high quality embryo
+
+375
+00:27:03,870 --> 00:27:07,690
+grade 1 معناه الخلايا الـ blastomere الـ blastomere 
+
+376
+00:27:07,690 --> 00:27:11,610
+الموجودة داخل الـ embryo متساوية في الحجم وما في
+
+377
+00:27:11,610 --> 00:27:15,970
+عندها fragmentation grade 2 متساوية في الحجم ولكن 
+
+378
+00:27:15,970 --> 00:27:20,430
+في القليل من الـ fragmentation grade 3 cells are
+
+379
+00:27:20,430 --> 00:27:24,990
+unequal in the size no fragmentation to moderate
+
+380
+00:27:24,990 --> 00:27:29,430
+fragmentation يعني ما في عندها تساوي في الحجم و
+
+381
+00:27:29,430 --> 00:27:35,190
+خلية عند مثلًا في اليوم grade 3 في اليوم الثاني في
+
+382
+00:27:35,190 --> 00:27:37,150
+اليوم الثاني المفروض يكون عندي أربع خلايا لجأت
+
+383
+00:27:37,150 --> 00:27:40,270
+ثلاث خلايا أكبر وخلايا صغيرة ما في عندي تساوي في
+
+384
+00:27:40,270 --> 00:27:44,770
+الحجم فبسميها grade 3 وعندي الـ fragmentation بدأ
+
+385
+00:27:44,770 --> 00:27:50,030
+يظهر moderate أما grade 4 هي عبارة عن الـ cells are
+
+386
+00:27:50,030 --> 00:27:53,730
+of equal or unequal size fragmentation is moderate
+
+387
+00:27:53,730 --> 00:27:56,310
+to heavy في عندي fragmentation بشكل كبير جداً تاب 
+
+388
+00:27:56,310 --> 00:28:01,570
+سؤالي متى أعمل evaluation أو grading للـ embryo في
+
+389
+00:28:01,570 --> 00:28:04,710
+اليوم الأول من انقسام؟ يوم الثاني ويوم الثالث لأ
+
+390
+00:28:04,710 --> 00:28:09,710
+في يوم الترجيع بعمل عملية grading أو evaluation أو
+
+391
+00:28:09,710 --> 00:28:13,010
+ممكن أبدأ في اليوم الثالث اليوم الثالث أعمل
+
+392
+00:28:13,010 --> 00:28:16,510
+evaluation اليوم الرابع اليوم الخامس ويوم الترجيع
+
+393
+00:28:16,510 --> 00:28:19,550
+مهم جداً عشان أعرف والله هذا الـ embryo رقم واحد
+
+394
+00:28:19,550 --> 00:28:23,410
+grade واحد رقم خمسة grade اثنين رقم عشرة grade
+
+395
+00:28:23,410 --> 00:28:27,790
+واحد فبرجع فقط لـ grade واحد بين جثين high quality
+
+396
+00:28:27,790 --> 00:28:32,090
+يعني grade واحد معناها high quality وتتميز بوجود
+
+397
+00:28:33,010 --> 00:28:37,750
+تناسق وتساوي في حجم الخلايا الموجودة داخل الـ
+
+398
+00:28:37,750 --> 00:28:40,810
+embryo blastomere بالإضافة إلى عدم وجود
+
+399
+00:28:40,810 --> 00:28:45,770
+fragment في الـ cytoplasm كيف تتم عملية الإرجاع؟
+
+400
+00:28:45,770 --> 00:28:50,070
+صورة توضح معظم الـ steps اللي احنا تكلمنا عنها في
+
+401
+00:28:50,070 --> 00:28:53,940
+عملية الإجراء نبدأ بالخطوة الأولى وهي عبارة عن 
+
+402
+00:28:53,940 --> 00:28:57,340
+ovarian stimulation الزوجة بتخضع لـ agonist أو 
+
+403
+00:28:57,340 --> 00:29:00,520
+الـ antagonist ovarian stimulation protocol سواء
+
+404
+00:29:00,520 --> 00:29:06,700
+كانت short أو long أو ultra short short long ultra
+
+405
+00:29:06,700 --> 00:29:14,620
+short protocol بعد كده المبيض بيبدا البويضات 
+
+406
+00:29:14,620 --> 00:29:17,520
+الفولك اللي بتنمو البويضات تنضج بصير عندي 
+
+407
+00:29:17,520 --> 00:29:21,960
+aspiration for egg واللي سميتها egg pick up بعد كده
+
+408
+00:29:21,960 --> 00:29:25,060
+الـ egg pick up بتسيلها عملية treatment عن طريق الـ 
+
+409
+00:29:25,060 --> 00:29:29,780
+denudation وخلافه في نفس اللحظة باجي بعمل semen
+
+410
+00:29:29,780 --> 00:29:36,360
+analysis للذكر و semen preparation بعد كده بعمل
+
+411
+00:29:36,360 --> 00:29:40,140
+fertilization إما باستخدام الـ IVF إنه بوايضة مع الـ
+
+412
+00:29:40,140 --> 00:29:43,460
+sperm أو باستخدام الـ ICSI  درجة الحقن المجهري
+
+413
+00:29:43,460 --> 00:29:47,860
+بعد عملية الـ fertilization تبدأ البويضة بالانقسام 
+
+414
+00:29:47,860 --> 00:29:55,160
+مثل 2 خليتين، 4 خلايا، ثم 8 خلايا ثم 16 
+
+415
+00:29:55,160 --> 00:29:59,220
+و 32 بعد كده لما تصل لمرحلة الـ morula
+
+416
+00:29:59,220 --> 00:30:05,280
+أو الـ blastocyst باجي بعملية الإرجاع من خلال
+
+417
+00:30:05,280 --> 00:30:09,280
+مرحلة بنسميها Embryo Transfer وعملية الإرجاع لا
+
+418
+00:30:09,280 --> 00:30:13,940
+تحدث إلا للأجنة اللي تعتبر grade one كـ first
+
+419
+00:30:13,940 --> 00:30:14,440
+chance
+
+420
+00:30:21,550 --> 00:30:24,790
+الأخير الموضوع اللي بنتكلم فيه هو الـ 
+
+421
+00:30:24,790 --> 00:30:31,730
+cryopreservation كيف نقوم بعملية حفظ
+
+422
+00:30:31,730 --> 00:30:38,030
+البويضة أو حفظ الأجنة عندي خمس أجنة عمر
+
+423
+00:30:38,030 --> 00:30:40,950
+السيدة أقل من ثلاثين سنة يعني لازم بناء على
+
+424
+00:30:40,950 --> 00:30:45,920
+القانون أرجع جنين واحد والباقي الأجنة أعملهم بعمل لهم 
+
+425
+00:30:45,920 --> 00:30:49,760
+Cryopreservation شو يعني Cryopreservation؟ كيف
+
+426
+00:30:49,760 --> 00:30:54,600
+نقوم بعمل Cryopreservation؟ فعملية التقنيات
+
+427
+00:30:54,600 --> 00:30:59,920
+المساعدة على الإنجاب تعتبر أفضل التقنية .. تقنية
+
+428
+00:30:59,920 --> 00:31:03,120
+الـ IVF طبعا في الوضع الحالي أفضل التقنيات التي
+
+429
+00:31:03,120 --> 00:31:07,540
+تستخدم لحل مشكلة ال infertility عند الفيميل
+
+430
+00:31:07,540 --> 00:31:12,060
+بالإضافة إلى عملية حفظ ال fertility للميل والفيميل
+
+431
+00:31:12,060 --> 00:31:15,710
+كيف يعني حفظ ال fertility؟ يعني في ميل بدأت تتعرض
+
+432
+00:31:15,710 --> 00:31:20,130
+لراديو ثيرابي كيمو ثيرابي باجي بخليها تخضع ل
+
+433
+00:31:20,130 --> 00:31:24,690
+ovarian stimulation بجمع البويضات والبويضات بعملها
+
+434
+00:31:24,690 --> 00:31:32,330
+cryopreservation حفظ أو عندي ميل بده يعمل إخصاب هو
+
+435
+00:31:32,330 --> 00:31:35,690
+والـ cabulist بتاعه بده يعمل إخصاب مش مابقدر يجيب
+
+436
+00:31:35,690 --> 00:31:38,550
+عينة دائماً مش دائماً ال parameter بتاعة ال semen
+
+437
+00:31:38,550 --> 00:31:42,530
+fluid بتكون طبيعية فمرة من المرات جاب عينة لجنينها 
+
+438
+00:31:42,770 --> 00:31:46,530
+Full Normal خليني أسميها بهذا الشكل أو Normal
+
+439
+00:31:46,530 --> 00:31:50,290
+بالنسبة لـ 50% فبلجأ إنه أحفظ الـ spermatozoa عن
+
+440
+00:31:50,290 --> 00:31:54,830
+طريق الـ Cryopreservation حتى تتم عملية الـ IVF
+
+441
+00:31:54,830 --> 00:31:58,510
+نجح أول حاجة جاميط الـ Cryopreservation لما أقول
+
+442
+00:31:58,510 --> 00:32:01,590
+جاميط الـ Cryopreservation يعني عملية تخزين
+
+443
+00:32:01,590 --> 00:32:05,150
+الجاميطات الأنثوية متمثلة في البويضات أو الجاميطات
+
+444
+00:32:05,150 --> 00:32:08,870
+الذكرية متمثلة في الـ sperm ممكن أن أحفظهم ممكن
+
+445
+00:32:08,870 --> 00:32:14,130
+أحفظهم ممكن يكونوا available ممكن يعطوا نتيجة في
+
+446
+00:32:14,130 --> 00:32:17,790
+مُباعد صحيح ممكن يكونوا available ويعطوا نتيجة إذا
+
+447
+00:32:17,790 --> 00:32:22,650
+عملية الجاميط cryopreservation تعتبر عملية مهمة جداً
+
+448
+00:32:22,650 --> 00:32:27,870
+للحفاظ على ال fertility for male and female before
+
+449
+00:32:27,870 --> 00:32:31,910
+exposure and this is process of care before
+
+450
+00:32:31,910 --> 00:32:35,250
+exposure to the cytotoxic therapy or chemotherapy
+
+451
+00:32:36,060 --> 00:32:38,940
+ممكن أعمل جاميط ممكن أعمل جاميط cryopreservation
+
+452
+00:32:38,940 --> 00:32:42,600
+ممكن أعمل جنين ممكن أعمل embryo cryopreservation
+
+453
+00:32:42,600 --> 00:32:47,720
+طبعاً هذه بتعطي قابلية للإنجاب في مُباعد للميل
+
+454
+00:32:47,720 --> 00:32:52,880
+والفيميل The ability of  Glycerol to act as a
+
+455
+00:32:52,880 --> 00:32:56,260
+cryoprotective agent during freezing and thawing
+
+456
+00:32:56,260 --> 00:33:01,420
+of spermatozoa was the fairest report in 1949
+
+457
+00:33:01,420 --> 00:33:05,520
+طبعاً أول ما تم استخدام الـ cryoprotective agent
+
+458
+00:33:05,520 --> 00:33:10,140
+التي تحمي الجميطات من عملية التكسر والانهيار
+
+459
+00:33:10,140 --> 00:33:14,260
+استخدمه لـ glycerol كان هو أول cryoprotective
+
+460
+00:33:14,260 --> 00:33:20,160
+agent وتم استخدامه في عام 1949 وفيما بعد كان أول
+
+461
+00:33:20,160 --> 00:33:25,940
+طفل نتج من عملية جاميط cryopreservation تم تسجيلها
+
+462
+00:33:25,940 --> 00:33:31,740
+في عام 1950 وهو عبارة عن طفل أنجب بعد ما تم تلقيح
+
+463
+00:33:31,740 --> 00:33:35,820
+البويضة من cryopreservative أو cryopreserved sperm
+
+464
+00:33:35,820 --> 00:33:43,400
+تم تخزينه باستخدام ال cryopreservation survival
+
+465
+00:33:43,400 --> 00:33:46,820
+fertilization and fetal development followed
+
+466
+00:33:46,820 --> 00:33:50,340
+cryopreservation of unfertilized mouse or oocyte
+
+467
+00:33:50,340 --> 00:33:56,180
+using DMSO were the first report in 1972 يعني
+
+468
+00:33:56,180 --> 00:34:00,850
+بمعنى آخر بعد كده تم تطوير بعض الـ cryoprotective
+
+469
+00:34:00,850 --> 00:34:05,170
+agent بخلاف الجليسرول فاستخدموا الديمسو والديمسو هي
+
+470
+00:34:05,170 --> 00:34:10,610
+عبارة عن مادة كيميائية إلى حد ما تستخدم as
+
+471
+00:34:10,610 --> 00:34:15,050
+cryopreservative agent زيها زي الجليسرول وتم 
+
+472
+00:34:15,050 --> 00:34:19,630
+إعطاء نتائج جدا رائعة في عملية الـ
+
+473
+00:34:19,630 --> 00:34:22,590
+cryopreservation والحفاظ على الجميطات من عملية
+
+474
+00:34:22,590 --> 00:34:26,350
+الانهيار والتكسُر طيب سؤالي when the oocyte
+
+475
+00:34:26,350 --> 00:34:29,410
+fertilizing .. fertilizing كان okay متى أنا ممكن
+
+476
+00:34:29,410 --> 00:34:35,290
+أعمل fertili .. متى ممكن أعمل ال freezing لل
+
+477
+00:34:35,290 --> 00:34:39,830
+oocyte تحت عنوان when the oocyte freezing كان okay
+
+478
+00:34:39,830 --> 00:34:45,090
+متى ممكن اعمل freezing لل oocyte طبعاً في عندي أكثر
+
+479
+00:34:45,090 --> 00:34:49,250
+من حالة ممكن أعملها freezing طبعاً women محتاجة
+
+480
+00:34:49,250 --> 00:34:52,090
+أنها تعمل .. تأخذ جرعة chemotherapy أو
+
+481
+00:34:52,090 --> 00:34:56,040
+radiotherapy ولكن عندها رغبة في الإنجاب فيما بعد
+
+482
+00:34:56,040 --> 00:34:59,940
+لأن سنها ما زال صغير ثلاثين سنة مثلاً أو أواخر
+
+483
+00:34:59,940 --> 00:35:03,580
+العشرينات ولكن شُقة الأقدار أن صار عندها cancer
+
+484
+00:35:03,580 --> 00:35:07,320
+راحت تعمل ريديو ثيرابي كيميو ثيرابي شرعت فبدها
+
+485
+00:35:07,320 --> 00:35:11,500
+تنجب فيما بعد فممكن نعمل لها oocyte freezing من خلال
+
+486
+00:35:11,500 --> 00:35:15,540
+إدخالها في برنامج ovarian stimulation وجمع أكبر
+
+487
+00:35:15,540 --> 00:35:19,840
+عدد من البويضات وتخزينها وبعد فترة زمنية من انتهاء
+
+488
+00:35:19,840 --> 00:35:23,460
+الحالة الموجودة حالياً أو انتهاء جرعة الكيموثيرابي
+
+489
+00:35:23,460 --> 00:35:28,220
+ممكن تبدأ بعملية الـcycling الجديدة اللي لها من
+
+490
+00:35:28,220 --> 00:35:32,760
+خلال عملية الـthawing for oocyte freezing بعدين ال
+
+491
+00:35:32,760 --> 00:35:37,420
+fertilization بعض ال medication زي حكينا ال radio
+
+492
+00:35:37,420 --> 00:35:40,440
+therapy والكيموثيرابي اللي ممكن تدمر ال fertility
+
+493
+00:35:40,440 --> 00:35:43,820
+الخاصة بالفيميل  oocyte freezing before treatment
+
+494
+00:35:43,820 --> 00:35:47,560
+maybe enable you to have biological children later
+
+495
+00:35:47,560 --> 00:35:51,900
+أكيد women undergoing in vitro fertilization when
+
+496
+00:35:51,900 --> 00:35:56,180
+undergoing in vitro fertilization some people
+
+497
+00:35:56,180 --> 00:35:59,000
+preferred egg fertilization to embryo freezing for
+
+498
+00:35:59,000 --> 00:36:03,980
+ethical reasons women wish to preserve young egg
+
+499
+00:36:03,980 --> 00:36:07,620
+now for future use يعني في أكثر من حالة من حالات
+
+500
+00:36:07,620 --> 00:36:11,640
+اللي حالياً صارت المشكلة تظهر على الصّرح بكميات
+
+501
+00:36:11,640 --> 00:36:16,810
+كبيرة جداً وفي مجتمعاتنا العربية خصوصاً في الناس
+
+502
+00:36:16,810 --> 00:36:20,270
+اللي بتشتغل as fashionist على سبيل المثال بتقوم
+
+503
+00:36:20,270 --> 00:36:26,430
+بتخزين بويضاتِها الشابة علشان مايصير عملية إنجاب
+
+504
+00:36:26,430 --> 00:36:30,570
+وعملية حمل خلال فترة عملها على سبيل المثال وبعد
+
+505
+00:36:30,570 --> 00:36:34,210
+فترة زمنية عشر سنين عشرين سنة whatever يعني ال
+
+506
+00:36:34,210 --> 00:36:38,410
+calendar الخاصة فيها وقت ما بدها تنجب تروح تستخدم
+
+507
+00:36:38,410 --> 00:36:41,590
+البويضات المخزنة زي ما في عندنا sperm banking في
+
+508
+00:36:41,590 --> 00:36:45,070
+عندنا oocyte banking صار حالياً حتى الـ oocyte
+
+509
+00:36:45,070 --> 00:36:48,130
+banking ممكن تؤجر ممكن تباع زي الـ sperm banking
+
+510
+00:36:48,130 --> 00:36:52,190
+ممكن تباع ما في مشكلة بس طبعاً هذا مش في مجتمعاتنا
+
+511
+00:36:52,190 --> 00:36:56,150
+موجودة في المجتمعات الغربية ولكن في مجتمعاتنا بدأت
+
+512
+00:36:56,150 --> 00:37:00,310
+تظهر ظاهرة جديدة وهي الظاهرة الموجودة في آخر ال
+
+513
+00:37:00,310 --> 00:37:04,310
+slide التي بعنوان women wish to preserve younger
+
+514
+00:37:04,310 --> 00:37:12,180
+egg now for if youth are used طبعاً خلال عملية الـ
+
+515
+00:37:12,180 --> 00:37:15,300
+Cryopreservation أو الـ freezing للـ Oocyte الـ
+
+516
+00:37:15,300 --> 00:37:18,680
+Oocyte ما بتتمهد العملية بشكل سلس بشكل سهل الـ
+
+517
+00:37:18,680 --> 00:37:22,900
+Oocyte بتتعرض لعديد من الـ challenges لعديد من
+
+518
+00:37:22,900 --> 00:37:26,480
+المخاطر قد تؤدي إلى حدوث rupture في الـ Oocyte
+
+519
+00:37:26,480 --> 00:37:32,660
+وفقدان الـ Oocyte بفعل تكوين crystal ice داخل الـ
+
+520
+00:37:32,660 --> 00:37:36,640
+cytoplasm الخاص بالـ Oocyte مما يؤدي إلى تمزيق
+
+521
+00:37:36,640 --> 00:37:40,410
+الغشاء الخلوي الخاص بالـ Oocyte white layer هذه
+
+522
+00:37:40,410 --> 00:37:45,850
+أشهر المعوقات التي تتواجه
+
+523
+00:37:45,850 --> 00:37:48,950
+الـ oocyte خلال عملية الـ freezing أو الـ
+
+524
+00:37:48,950 --> 00:37:51,390
+cryopreservation ممكن أن أتجنب تكوين ال ice
+
+525
+00:37:51,390 --> 00:37:56,070
+crystal and toxic concentration of salt which are
+
+526
+00:37:56,070 --> 00:37:59,130
+the two main cause of the cell death associated
+
+527
+00:37:59,130 --> 00:38:02,110
+with cryopreservation while maintaining the
+
+528
+00:38:02,110 --> 00:38:05,010
+function of intracellular organelle and the
+
+529
+00:38:05,010 --> 00:38:10,070
+viability of the embryo oocyte يعني أشهر نقطتين
+
+530
+00:38:10,070 --> 00:38:14,270
+تتعرض إليه أو خطرين تتعرض إليهما الـ oocyte خلال
+
+531
+00:38:14,270 --> 00:38:18,470
+عملية الـ cryopreservation أو الـ freezing تكوين
+
+532
+00:38:18,470 --> 00:38:23,850
+ال ice crystal و ال toxicity الخاصة بالمواد التي
+
+533
+00:38:23,850 --> 00:38:29,170
+تستخدم ولكن حالياً أصبح هناك إمكانية أن أمنع خطر
+
+534
+00:38:29,170 --> 00:38:32,890
+النقطتين هدول من خلال استخدام ما يعرف باسم الـ
+
+535
+00:38:32,890 --> 00:38:38,140
+cryoprotective additive or cryoprotective agent إذن
+
+536
+00:38:38,140 --> 00:38:42,100
+هناك خطرين تواجهها البويضة خلال عملية التخزين
+
+537
+00:38:42,100 --> 00:38:47,000
+تكوين ال ice crystal خطر و ال toxicity الخاصة
+
+538
+00:38:47,000 --> 00:38:51,080
+بالمواد المستخدمة ممكن أنا أتجنب هذين الخطرين من
+
+539
+00:38:51,080 --> 00:38:55,140
+خلال استخدام شيء بسميه CPA وهي cryoprotective
+
+540
+00:38:55,140 --> 00:38:59,060
+agent من أشهر الـ cryoprotective agent هنتكلم عنها
+
+541
+00:38:59,060 --> 00:39:02,880
+كمان شوية exposure to cryoprotective agent support
+
+542
+00:39:02,880 --> 00:39:05,640
+the dehydration of the cell and reduce
+
+543
+00:39:05,640 --> 00:39:08,920
+intracellular ice formation إذن ال cryoprotective
+
+544
+00:39:08,920 --> 00:39:13,200
+agent بعمل dehydration للخلية فبالتالي بنزع منها
+
+545
+00:39:13,200 --> 00:39:16,780
+الماء فبالتالي ما بتتكون ال ice crystal داخل
+
+546
+00:39:16,780 --> 00:39:21,230
+الخلية من أشهر الـ CPA على سبيل المثال، هنتقسم إلى
+
+547
+00:39:21,230 --> 00:39:24,270
+قسمين القسم الأول بيسميه Intracellular والقسم
+
+548
+00:39:24,270 --> 00:39:27,730
+الثاني بيسميه Extracellular الـ Intracellular
+
+549
+00:39:27,730 --> 00:39:33,330
+membrane permitting زي Glycerol، Dimethyl glycerol
+
+550
+00:39:33,330 --> 00:39:40,390
+والإيثيلينيجليسرول إذا عندي الجليسيرول،
+
+551
+00:39:40,390 --> 00:39:44,230
+Dimethyl glycerol، إيثيليني جليكول أربعة أنواع من
+
+552
+00:39:44,230 --> 00:39:49,520
+أنواع الـ Intracellular membrane permitting أما الـ
+
+553
+00:39:49,520 --> 00:39:53,500
+Extracellular Membrane Non-permenting زي السكروز
+
+554
+00:39:53,500 --> 00:39:58,040
+والجلوكوز والأمينو acids والبروتينات والليبوبروتينات إذا
+
+555
+00:39:58,040 --> 00:40:01,420
+في عندي نوعين منهم واحد Intracellular وواحد
+
+556
+00:40:01,420 --> 00:40:08,760
+Extracellular طبعا الـ Pre-Nipple-CPA Removing
+
+557
+00:40:08,760 --> 00:40:14,300
+Water بشتغل على إزالة الـ Intracellular بشتغل على
+
+558
+00:40:14,300 --> 00:40:19,380
+إزالة الماء من داخل الـ Oocyte من خلال الإزالة
+
+559
+00:40:19,380 --> 00:40:23,360
+التدريجية Why? An osmotic gradient and partially
+
+560
+00:40:23,360 --> 00:40:26,580
+occupy the place of intracellular water while the 
+
+561
+00:40:26,580 --> 00:40:29,880
+extracellular في المقابل extracellular increase
+
+562
+00:40:29,880 --> 00:40:34,580
+the extracellular osmolarity generating an osmotic
+
+563
+00:40:34,580 --> 00:40:37,420
+gradient across the cell membrane supporting the
+
+564
+00:40:37,420 --> 00:40:39,800
+dehydration of the cell before CP
+
+565
+00:40:42,590 --> 00:40:46,190
+إذن في  هناك طريقتين للعمل الطريقة الـ
+
+566
+00:40:46,190 --> 00:40:49,210
+intracellular إنه بعمل removing للماء الموجود داخل 
+
+567
+00:40:49,210 --> 00:40:53,430
+الخلية من خلال الـ osmotic gradient  وبحتل مكان
+
+568
+00:40:53,430 --> 00:40:56,750
+الماء بشكل تدريجي في المقابل الـ extracellular
+
+569
+00:40:56,750 --> 00:41:01,510
+بعمل زيادة للـ extracellular osmolarity مما يؤدي 
+
+570
+00:41:01,510 --> 00:41:06,090
+إلى إخراج الماء بشكل كامل وعمل ال dehydration ولكن
+
+571
+00:41:06,090 --> 00:41:10,570
+تحدث قبل ال CB والمقصود بال CB في هذه الفقرة مقصود
+
+572
+00:41:10,570 --> 00:41:15,490
+بالـ CB هي ال cryopreservation at the same time it
+
+573
+00:41:15,490 --> 00:41:18,050
+prevents the rapid enter of the water into the 
+
+574
+00:41:18,050 --> 00:41:21,170
+cell after thawing during rehydration of the 
+
+575
+00:41:21,170 --> 00:41:26,410
+permitting CBA طيب أي بويضة صارت لها freezing أو 
+
+576
+00:41:26,410 --> 00:41:29,250
+صارت لها cryopreservation لما بدي استخدمها لازم
+
+577
+00:41:29,250 --> 00:41:34,130
+أعملها thawing شو يعني thawing يعني إذابة بدي 
+
+578
+00:41:34,130 --> 00:41:39,350
+أعملها إذابة وأرجعها  لـ intracellular في 
+
+579
+00:41:39,350 --> 00:41:43,990
+نفس اللحظة أنه هو بيحافظ على ال oocyte خلال عملية 
+
+580
+00:41:43,990 --> 00:41:47,590
+الـ cryopreservation أيضا بيحافظ على ال oocyte خلال
+
+581
+00:41:47,590 --> 00:41:52,410
+عملية thawing من خلال شو؟ من خلال منع ما يسمى
+
+582
+00:41:52,410 --> 00:41:56,290
+rapid enter of water into the cell after thawing
+
+583
+00:41:56,290 --> 00:42:00,270
+يعني بيمنع دخول الماء أو بيمنع دخول الماء السريع 
+
+584
+00:42:00,270 --> 00:42:06,390
+داخل ال oocyte خلال عملية الاذابة أو عملية الإذابة
+
+585
+00:42:06,390 --> 00:42:10,170
+أو عملية الـ rehydration مما يحافظ على البويضة في
+
+586
+00:42:10,170 --> 00:42:15,790
+أفضل صورة ممكنة لها إذن الـ Intracellular ما بحمل
+
+587
+00:42:15,790 --> 00:42:20,430
+بويضة خلال عملية التجميد فقط لأ بحميها خلال عملية 
+
+588
+00:42:20,430 --> 00:42:24,530
+الـ rehydration من خلال إيقاف عملية تدفق الماء
+
+589
+00:42:24,530 --> 00:42:29,550
+السريع داخل البويضة خلال أو بعد عملية الـ thaw
+
+590
+00:42:31,020 --> 00:42:33,200
+Dehydration of the cell mainly depending on the 
+
+591
+00:42:33,200 --> 00:42:36,680
+permeability properties of the cell membrane دخول
+
+592
+00:42:36,680 --> 00:42:39,120
+الماء وخروج الماء وبالذات أنا بحكي هنا على الـ 
+
+593
+00:42:39,120 --> 00:42:41,420
+dehydration خروج الماء خلال عملية الـ 
+
+594
+00:42:41,420 --> 00:42:45,360
+cryopreservation يعتمد بشكل أساسي على الـ 
+
+595
+00:42:45,360 --> 00:42:47,360
+permeability of the cell membrane إذا كانت ال cell
+
+596
+00:42:47,360 --> 00:42:50,660
+membrane permeability جيدة إذا العملية بتستمر
+
+597
+00:42:50,660 --> 00:42:54,440
+وتنتهي بنجاح ال permeability properties of the 
+
+598
+00:42:54,440 --> 00:42:58,160
+immature and mature oocyte different and can be
+
+599
+00:42:58,160 --> 00:43:02,320
+there by seven fold between individual human of 
+
+600
+00:43:03,160 --> 00:43:07,600
+Oocite in the Metaphase-II أكيد طالما أنا عندي 
+
+601
+00:43:07,600 --> 00:43:11,140
+Oocite هذا ال Oocite لما تكون mature الـ 
+
+602
+00:43:11,140 --> 00:43:15,320
+permeability تختلف عنما تكون immature فبالتالي في
+
+603
+00:43:15,320 --> 00:43:19,940
+اختلاف هذا الاختلاف يقدر بسبع مرات مختلف أو سبع
+
+604
+00:43:19,940 --> 00:43:24,320
+أضعاف الاختلاف بين permeability of mature Oocite
+
+605
+00:43:24,320 --> 00:43:27,930
+and immature Oocite هذا الاختلاف في الـ
+
+606
+00:43:27,930 --> 00:43:31,730
+permeability  الـ permeability قد تتأثر بقوة  قوة على
+
+607
+00:43:31,730 --> 00:43:35,170
+نتيجة الانتقال اللازمة من الـ oocyte لكنها يمكن أن 
+
+608
+00:43:35,170 --> 00:43:39,290
+تكون  محكومة بإنعكاس مقاومة الـ non-permeability الـ
+
+609
+00:43:39,290 --> 00:43:44,090
+CpA ومقاومة البيئة طالما أن في عندي permeability
+
+610
+00:43:44,090 --> 00:43:46,510
+مختلفة ما بين ال mature oocyte و ال immature
+
+611
+00:43:46,510 --> 00:43:51,430
+oocyte هذا الاختلاف وجدوا أنه بلعب دور كبير جدا في
+
+612
+00:43:51,910 --> 00:43:59,590
+الـ outcome of cell freezing يعني نجاح 
+
+613
+00:43:59,590 --> 00:44:02,830
+الـ oocyte freezing باستخدام ال slow method هل
+
+614
+00:44:02,830 --> 00:44:07,360
+تنجح أم لا تنجح؟ ولكن في المقابل وجدوا أن هناك
+
+615
+00:44:07,360 --> 00:44:11,920
+قابلية للتحكم في هذا الأمر من خلال زيادة مستوى للـ
+
+616
+00:44:11,920 --> 00:44:14,760
+cryoprotective agent اللي بيستخدموه وخاصة إن إذا
+
+617
+00:44:14,760 --> 00:44:18,280
+كان intracellular وخاصة إن إذا كان عفوا non
+
+618
+00:44:18,280 --> 00:44:21,300
+permeable وهو الـ extracellular بالإضافة إلى
+
+619
+00:44:21,300 --> 00:44:25,040
+التحكم في كمية الحرارة ال environment temperature
+
+620
+00:44:25,040 --> 00:44:28,940
+الموجودة إذا مافي حاجة اسمها خطأ مطلق مافي حاجة
+
+621
+00:44:28,940 --> 00:44:33,510
+اسمها عامل يؤثر بشكل مطلق لأ في عندي إمكانية للتحكم 
+
+622
+00:44:33,510 --> 00:44:38,070
+في هذه الأمور By having the concentration of non
+
+623
+00:44:38,070 --> 00:44:44,530
+-permitting cryoprotective agent increase عن طريق
+
+624
+00:44:44,530 --> 00:44:51,350
+زيادة الـ CPA كتركيزه فممكن أستخدم سكروز 0.2 أو 0.3 
+
+625
+00:44:51,350 --> 00:44:55,170
+مولار وخدوا بالكم أنا قلت non-permitting يعني عبارة 
+
+626
+00:44:55,170 --> 00:45:01,200
+عن بناء على هذه الصورة الـ Extracellular
+
+627
+00:45:01,200 --> 00:45:06,760
+فممكن أزيدها لتصل تركيز السكاروز as CpA إلى 0.2 أو
+
+628
+00:45:06,760 --> 00:45:12,140
+0.3 مولار هذا بعمل زيادة في survivor rate لل
+
+629
+00:45:12,140 --> 00:45:16,720
+oocyte خلال عملية freezing over all freezing 
+
+630
+00:45:16,720 --> 00:45:20,020
+fertilization rate of freezing thawing oocyte 
+
+631
+00:45:20,020 --> 00:45:25,180
+appeared to be similar to those of fresh oocyte عن
+
+632
+00:45:25,180 --> 00:45:30,320
+زيادة الـ CBA concentration علشان يصل إلى 0.2 أو 0
+
+633
+00:45:30,320 --> 00:45:35,420
+.3 مولار بيخلّي ال survival rate عالي جدا بيخلّي
+
+634
+00:45:35,420 --> 00:45:39,940
+ال fertilization rate للبويضات المخصبة التي نتجت 
+
+635
+00:45:39,940 --> 00:45:43,300
+بعد عملية ال throwing تشبه ال fertilization rate
+
+636
+00:45:43,300 --> 00:45:47,280
+للبوايضة ال fresh يعني مافي عندي اختلاف؟ اه مافي 
+
+637
+00:45:47,280 --> 00:45:51,000
+عندي اختلاف بينهم طبعا هذا مش رأيي بناء على أبحاث
+
+638
+00:45:51,000 --> 00:45:55,980
+ودراسات أجريت على بويضات خُصّبت بعد أن حدث لها 
+
+639
+00:45:55,980 --> 00:45:58,900
+عملية thawing وهي تعرضت لـ cryopreservation
+
+640
+00:45:58,900 --> 00:46:02,940
+باستخدام الـ CPA الـ external extracellular بتركيز 0
+
+641
+00:46:02,940 --> 00:46:09,340
+.2 و 0.3 مولار طبعا قبل الـ slow cooling 
+
+642
+00:46:09,340 --> 00:46:12,420
+dehydration of the embryo site is carried out by 
+
+643
+00:46:12,420 --> 00:46:16,830
+exposure to a mixture of permeable and non
+
+644
+00:46:16,830 --> 00:46:20,570
+-permeable CBA duration 10 minutes يعني ممكن أنا 
+
+645
+00:46:20,570 --> 00:46:26,990
+أزيد كمان ال survivor rate لل Oocyte و أمنع ال bad 
+
+646
+00:46:26,990 --> 00:46:32,790
+effect ل ال CBA من خلال عمل mixing أو تعريض الـ 
+
+647
+00:46:32,790 --> 00:46:36,490
+Oocyte لخليط من ال intracellular و الـ
+
+648
+00:46:36,490 --> 00:46:41,870
+extracellular CBA لمدة عشرة minutes Currently 
+
+649
+00:46:41,870 --> 00:46:46,820
+there are two methods حالياً في عندي طريقتين لعملية 
+
+650
+00:46:46,820 --> 00:46:49,740
+ال freezing طريقة بتسميها slow rate freezing و هي
+
+651
+00:46:49,740 --> 00:46:53,240
+طريقة بطيئة جدا بتاخد تلت ساعات أو ساعتين بناء على 
+
+652
+00:46:53,240 --> 00:46:56,240
+ال machine المستخدمة وطريقة بتسميها طريقة سريعة 
+
+653
+00:46:56,240 --> 00:46:59,580
+بتسميها ال vitrification إذا في عندنا ال oocyte و
+
+654
+00:46:59,580 --> 00:47:02,560
+ال embryo طريقتين لعملية ال freezing طريقة ال slow
+
+655
+00:47:02,560 --> 00:47:07,720
+rate freezing و هي تعتمد على machine وطريقة اسمها
+
+656
+00:47:07,720 --> 00:47:09,300
+very fast أو vitrification
+
+657
+00:47:13,020 --> 00:47:16,700
+طبعاً في مختبرات بتستخدم الطريقة الأولى وطريقة 
+
+658
+00:47:16,700 --> 00:47:20,280
+ناجحة وفي مختبرات بسبب الضغط اللي عمل عليها
+
+659
+00:47:20,280 --> 00:47:23,400
+بتستخدم طريقة ال vitrification طريقة ناجحة بشكل 
+
+660
+00:47:23,400 --> 00:47:27,840
+كبير جدا بتاخدش تقريبا دقيقة واحدة during rib
+
+661
+00:47:27,840 --> 00:47:32,540
+reservation cell are exposed to a number of stress
+
+662
+00:47:32,540 --> 00:47:35,940
+factors mechanical, thermal, chemical which can
+
+663
+00:47:35,940 --> 00:47:39,620
+lead to defect the cell functional and lead to 
+
+664
+00:47:39,620 --> 00:47:42,350
+cell death يعني خلال عملية الـ Cryopreservation
+
+665
+00:47:42,350 --> 00:47:47,070
+الخلية ما بتكون منعمة ما بتكون في بيئة optimal
+
+666
+00:47:47,070 --> 00:47:51,890
+condition لأ بتتعرض إلى بعض العوامل الضغطة سواء
+
+667
+00:47:51,890 --> 00:47:55,070
+كانت عوامل كيميائية أو بيئية أو حرارية أو 
+
+668
+00:47:55,070 --> 00:47:59,010
+ميكانيكية وأنت بتشتغل وأنت بتضغط عليها باستخدام ال
+
+669
+00:47:59,010 --> 00:48:03,830
+needle هذه كلها عوامل ممكن تؤدي إلى قتل الخلية أو
+
+670
+00:48:03,830 --> 00:48:08,490
+تؤدي إلى إيقاف وظيفتها إلى إيقاف وظيفتها بشكل عام
+
+671
+00:48:10,790 --> 00:48:13,630
+It has been demonstrated that oocyte are more
+
+672
+00:48:13,630 --> 00:48:17,470
+sensitive to cryodamage than later embryonic stage
+
+673
+00:48:17,470 --> 00:48:23,050
+بشكل عام حكوا ووجدوا أن البويضة إذا تعرضت لـ
+
+674
+00:48:23,050 --> 00:48:26,230
+Cryopreservation هيكون فرصة تدميرها أكثر من ال
+
+675
+00:48:26,230 --> 00:48:29,330
+embryo لأن ال embryo عنده resistant عالية ال
+
+676
+00:48:29,330 --> 00:48:33,770
+oocyte sensitive عشان كده معظم المراكز بيميلوا إلى
+
+677
+00:48:33,770 --> 00:48:37,890
+تجميد الأجنة وليس إلى تجميد البويضة لأن البويضة
+
+678
+00:48:37,890 --> 00:48:41,910
+بين لحظة ولحظة أخرى ممكن تتلف بينما الأجنة مقاومتها 
+
+679
+00:48:41,910 --> 00:48:45,450
+للتلف بفعل ال cryopreservation بتكون أعلى يعني ال
+
+680
+00:48:45,450 --> 00:48:49,910
+survival rate تبعتها أعلى slow rate of freezing
+
+681
+00:48:49,910 --> 00:48:53,730
+attempt to control biophysical properties of 
+
+682
+00:48:53,730 --> 00:48:57,730
+freezing such as a cooling and warming rate in 
+
+683
+00:48:57,730 --> 00:49:02,710
+conjunction with cryoprotectant to minimize advice
+
+684
+00:49:02,710 --> 00:49:08,210
+cellular event يعني فكرة slow freezing method هي
+
+685
+00:49:08,210 --> 00:49:13,210
+طريقة تعتمد على التحكم في درجات انخفاض الحرارة 
+
+686
+00:49:13,210 --> 00:49:17,430
+ودرجات ارتفاع الحرارة اعتمادًا على كمية الـ 
+
+687
+00:49:17,430 --> 00:49:21,150
+cryoprotectant الموجودة من أجل تقليل التأثير
+
+688
+00:49:21,150 --> 00:49:25,850
+السلبي الخاص بالـ cellular event اللي بتحدث خلال
+
+689
+00:49:25,850 --> 00:49:30,630
+عملية الـ cryopreservation في الـ slow freezing 
+
+690
+00:49:30,630 --> 00:49:35,030
+method بيصير cooling للخلايا to very low 
+
+691
+00:49:35,030 --> 00:49:38,650
+temperature circulating الخلايا لدرجة حرارة منخفضة 
+
+692
+00:49:38,650 --> 00:49:43,490
+جدا قد تصل إلى minus 30 كعدد درجة الحرارة التي يتم 
+
+693
+00:49:43,490 --> 00:49:46,590
+تناقصها في الدقيقة الواحدة while minimizing
+
+694
+00:49:46,590 --> 00:49:50,430
+intracellular ice crystal formation and at the
+
+695
+00:49:50,430 --> 00:49:52,990
+same time attempt to minimize the harmful
+
+696
+00:49:52,990 --> 00:49:56,390
+influence of increased salient concentration and 
+
+697
+00:49:56,390 --> 00:50:00,730
+osmotic stress إذن في ال slow freezing method هي
+
+698
+00:50:00,730 --> 00:50:06,150
+طريقة تعمل على تبريد الخلايا لكي تصل إلى درجة حرارة 
+
+699
+00:50:06,150 --> 00:50:10,770
+منخفضة جدا جدا بشرط أن تحافظ على الـ functional of
+
+700
+00:50:10,770 --> 00:50:16,290
+oocyte or embryo تقلل من تأثير التركيز المرتفعة
+
+701
+00:50:16,290 --> 00:50:21,230
+للمواد التي تستخدم والتي تؤدي إلى إطلاف الخلية
+
+702
+00:50:21,230 --> 00:50:25,510
+بالإضافة إلى تقليل التأثير السلبي للـ osmotic
+
+703
+00:50:25,510 --> 00:50:29,610
+stress، الـvitrification بيصير في عندي مش slow
+
+704
+00:50:29,610 --> 00:50:32,850
+freezing، لأ rapid freezing، أنه بيصير عملية cooling
+
+705
+00:50:32,850 --> 00:50:38,050
+سريع جدًا باستخدام تركيز عالٍ من الـ cryoprotectant
+
+706
+00:50:38,050 --> 00:50:43,290
+that solidified without forming ice crystal، يعني
+
+707
+00:50:43,290 --> 00:50:47,450
+الـvitrification تبريد سريع جدا باستخدام تركيز 
+
+708
+00:50:47,450 --> 00:50:51,090
+عالي من الـ cryoprotectant لمنع تكوين الـ ice crystal
+
+709
+00:50:51,090 --> 00:50:56,070
+هناخد إيش الفرق بين كل طريقة أو أخرى على سبيل
+
+710
+00:50:56,070 --> 00:50:59,230
+المثال، أن الـvitrification تقنية الـ oocyte والـ
+
+711
+00:50:59,230 --> 00:51:04,070
+embryo بصير فيها dehydration قبل عملية الـ cooling من 
+
+712
+00:51:04,070 --> 00:51:07,870
+خلال تعريضها إلى concentrating solution of the
+
+713
+00:51:07,870 --> 00:51:11,570
+cryoprotectant before plugging the sample directly 
+
+714
+00:51:11,570 --> 00:51:14,310
+into liquid nitrogen، بمعنى آخر أنه أنا بجيب
+
+715
+00:51:14,310 --> 00:51:18,250
+البويضة، البويضة بحضنها مع تركيز عالي من 
+
+716
+00:51:18,250 --> 00:51:23,950
+cryoprotectant بيخليها بيصلها dehydration، بعدين باخد 
+
+717
+00:51:23,950 --> 00:51:27,250
+البويضة وبلقيها في الـ liquid nitrogen، طبعا مش
+
+718
+00:51:27,250 --> 00:51:30,510
+بلقيها بلقيها بشكل عشوائي لأ فيها طريقة معينة أنه 
+
+719
+00:51:30,510 --> 00:51:34,710
+بستخدمها في حاجة بتسميها strip هنشوفها كمان شوية
+
+720
+00:51:34,710 --> 00:51:40,650
+زي الحاضنة طبعا كيف عملية الـ freezing بتتم with
+
+721
+00:51:40,650 --> 00:51:44,830
+low cooling rate تصل إلى point three لكل دقيقة 
+
+722
+00:51:44,830 --> 00:51:48,850
+يعني بيصير عملية اخفاض درجة حرارة point ثلاثة درجة
+
+723
+00:51:48,850 --> 00:51:55,130
+لكل دقيقة to about minus 30 سلسيوس لـ 40 سلسيوس
+
+724
+00:51:55,130 --> 00:52:02,030
+تتبع بإزالة حرارة الهواء لـ-50 سلسيوس في ساعة
+
+725
+00:52:02,030 --> 00:52:10,470
+لتحرير من الـ-80 سلسيوس لـ-150 سلسيوس قبل البداية
+
+726
+00:52:10,470 --> 00:52:14,430
+بالإنزال بالنيتروجين السائل يعني بيصير عندي انخفاض
+
+727
+00:52:14,430 --> 00:52:19,800
+وانخفاض تدريجي في درجة الحرارة من سالب ثلاثين لسالب
+
+728
+00:52:19,800 --> 00:52:24,860
+أربعين كل دقيقة، بعدين بيرتفع من سالب خمسين لسالب
+
+729
+00:52:24,860 --> 00:52:28,380
+خمسين لكل دقيقة، بعدين بيصير من سالب ثمانين
+
+730
+00:52:28,380 --> 00:52:33,240
+لسالب مئة وخمسين لكل دقيقة، شوف جدّيش عملية انخفاض
+
+731
+00:52:33,240 --> 00:52:37,700
+درجة الحرارة معدل انخفاضها، طبعا لازم تصل لسالب مئة
+
+732
+00:52:37,700 --> 00:52:42,540
+وخمسين درجة قبل الإلقاء في الـ liquid nitrogen، طيب
+
+733
+00:52:42,540 --> 00:52:47,210
+خلال الـ during أو خلال slow cooling بيصير
+
+734
+00:52:47,210 --> 00:52:50,130
+dehydration، وبعدين بيصير عندي حاجة بتسميها
+
+735
+00:52:50,130 --> 00:52:56,230
+continuous reduction for oocyte temperature أو 
+
+736
+00:52:56,230 --> 00:53:01,610
+خليني أسميه continuous reduction for temperature
+
+737
+00:53:01,610 --> 00:53:06,840
+قد تصل إلى ماينص ثلاثين درجة، after which any 
+
+738
+00:53:06,840 --> 00:53:12,060
+remaining water is super cooling، هذا عبارة عن
+
+739
+00:53:12,060 --> 00:53:15,400
+العملية، يعني بيصير خلال slow cooling بيصير في عندي
+
+740
+00:53:15,400 --> 00:53:19,800
+dehydration للبويضة وبعدين بيصير عندي خفض لدرجة
+
+741
+00:53:19,800 --> 00:53:24,940
+الحرارة بشكل مستمر بمعدل سالب ثلاثين قبل ما أنا 
+
+742
+00:53:24,940 --> 00:53:29,640
+استخدم الـ liquid nitrogen فيها، إذا هذه فكرة الـ
+
+743
+00:53:29,640 --> 00:53:31,980
+cooling، slow cooling أو الـ vitrification
+
+744
+00:53:35,900 --> 00:53:40,480
+الـ Embryo and oocyte cooled slowly to sub-zero
+
+745
+00:53:40,480 --> 00:53:45,140
+temperature of minus 30 to minus 40 Celsius before
+
+746
+00:53:45,140 --> 00:53:51,780
+rapidly cooling to arrive minus 196 Celsius
+
+747
+00:53:51,780 --> 00:53:55,520
+required rapidly warming thawing in warm water of
+
+748
+00:53:55,520 --> 00:54:00,400
+25 Celsius to 37 Celsius، يعني بيقول لي ببساطة اللي
+
+749
+00:54:00,400 --> 00:54:05,560
+الـ embryo هتخضع إلى عملية التبريد التدريجي والبطيء
+
+750
+00:54:05,820 --> 00:54:10,600
+لكي تصل إلى درجة حرارة أقل من الصفر أو تحت الصفر
+
+751
+00:54:10,600 --> 00:54:15,340
+تصل إلى سالب ثلاثين، بعدين سالب أربعين، بعدين تستمر
+
+752
+00:54:15,340 --> 00:54:18,880
+في التناقص بشكل تدريجي لتصل إلى سالب مئة وستة
+
+753
+00:54:18,880 --> 00:54:24,120
+وتسعين درجة مئوية، وهي في الغالب درجة حرارة الـ liquid
+
+754
+00:54:24,120 --> 00:54:28,140
+nitrogen، liquid nitrogen درجة حرارته سالب مئة وستة
+
+755
+00:54:28,140 --> 00:54:32,720
+وتسعين درجة مئوية، طبعا خلال هذه العملية خلاص
+
+756
+00:54:32,720 --> 00:54:36,780
+اتجمدت البويضة، ببدأ أرجع أعملها thawing، لازم أضيفها أو
+
+757
+00:54:36,780 --> 00:54:42,340
+أوضعها في حمام مائي بصل درجة حرارته 25 إلى 37 درجة
+
+758
+00:54:42,340 --> 00:54:46,980
+مئوية، Rapid thawing is followed by remove the CPA
+
+759
+00:54:46,980 --> 00:54:51,800
+from the embryo and oocyte، شو بيصير وشو بيحدث
+
+760
+00:54:51,800 --> 00:54:56,960
+خلال عملية الـ thawing بتم عملية إزالة وإخراج الـ
+
+761
+00:54:56,960 --> 00:55:00,160
+cryoprotective agent الموجود داخل الـ embryo أو 
+
+762
+00:55:00,160 --> 00:55:03,500
+الموجود داخل البويضة أو التخلص منه، هيحل محله مين؟
+
+763
+00:55:03,500 --> 00:55:07,060
+هيحل محله الماء، لأنه في الـ cryopreservation الماء 
+
+764
+00:55:07,060 --> 00:55:11,620
+طلع ودخل مكانه الـ CPA، في الـ thawing الـ CPA بيطلع
+
+765
+00:55:11,620 --> 00:55:15,480
+وتحل محله الماء تحت مصطلح الـ rehydration
+
+766
+00:55:15,480 --> 00:55:18,780
+rehydration of the cell is carried out in 
+
+767
+00:55:18,780 --> 00:55:22,400
+increasing concentration of permitting CPA
+
+768
+00:55:22,400 --> 00:55:25,480
+generally in the presence of increased
+
+769
+00:55:25,480 --> 00:55:29,140
+concentration of non-permitting CPA، إذا في عملية 
+
+770
+00:55:29,140 --> 00:55:33,090
+الـ thawing عبارة عن عملية بنسميها rehydration حيث 
+
+771
+00:55:33,090 --> 00:55:38,810
+بتتم إزالة وإخراج الـ CPA ويحل محله الماء كما كانت
+
+772
+00:55:38,810 --> 00:55:44,790
+الخلية فيما سبق، الـ vitrification وهي المصطلح الآخر
+
+773
+00:55:44,790 --> 00:55:49,210
+اللي سموه Ultra Rapid Cryopreservation، أول ما تم
+
+774
+00:55:49,210 --> 00:55:54,990
+استخدامه كان في بداية أو في منتصف عام 1980، هي طريقة
+
+775
+00:55:54,990 --> 00:55:58,630
+تختلف بشكل كبير جدًا عن slow freezing method، يتم 
+
+776
+00:55:58,630 --> 00:56:02,170
+فيها تجنب تكوين الـ ice crystal in the 
+
+777
+00:56:02,170 --> 00:56:06,290
+intracellular and extracellular space، يعني مش فقط 
+
+778
+00:56:06,290 --> 00:56:11,020
+بمنع تكوين الـ ice crystal في داخل الخلية الـ
+
+779
+00:56:11,020 --> 00:56:13,680
+intracellular، كمان بيعمل منع تكوينه في الـ
+
+780
+00:56:13,680 --> 00:56:19,120
+extracellular، في الـ vitrification عملية يتم فيها
+
+781
+00:56:19,120 --> 00:56:23,260
+ببساطة إنخفاض درجة الحرارة ومنع تكوين الـ ice
+
+782
+00:56:23,260 --> 00:56:28,500
+crystal من خلال الحصول واستخدام تركيز عالي من
+
+783
+00:56:28,500 --> 00:56:34,010
+الـ CPA يصل إلى من 4 إلى 8 مول per liter وتعريضها
+
+784
+00:56:34,010 --> 00:56:39,330
+لعملية التبريد السريع، يعني ممكن تنزل لـ -196 خلال 3
+
+785
+00:56:39,330 --> 00:56:43,870
+دقائق فقط، لغاية ما تاخدش ساعة أو ساعتين خلال الـ 
+
+786
+00:56:43,870 --> 00:56:48,090
+vitrification بيصير dehydration للبويضة أو الجنين
+
+787
+00:56:48,090 --> 00:56:52,690
+قبل ما تتعرض إلى الـ liquid nitrogen من خلال 
+
+788
+00:56:52,690 --> 00:56:56,610
+تحضيرها مع تركيز عالي من الـ CBA وهو الـ 
+
+789
+00:56:56,610 --> 00:57:01,060
+cryopreservating agent، طبعاً في عندي potential risk
+
+790
+00:57:01,060 --> 00:57:03,260
+associated with the vitrification procedure is the
+
+791
+00:57:03,260 --> 00:57:07,200
+high concentration of CPA، بس بالإضافة إلى الـ
+
+792
+00:57:07,200 --> 00:57:09,600
+toxicity اللي خاصة فيها، يعني نفس الـ factor اللي
+
+793
+00:57:09,600 --> 00:57:12,220
+ممكن يتأثر على نتيجة الـ slow freezing هي نفس الـ 
+
+794
+00:57:12,220 --> 00:57:13,900
+factor اللي ممكن يتأثر على نتيجة الـ
+
+795
+00:57:13,900 --> 00:57:16,480
+vitrification وهي عبارة عن التركيز العالية
+
+796
+00:57:16,480 --> 00:57:20,520
+للمواد الحافظة، بالإضافة إلى الـ toxicity اللي خاصة 
+
+797
+00:57:20,520 --> 00:57:24,220
+بها، الـ toxicity اللي خاصة بها ممكن أنا أعمل
+
+798
+00:57:24,220 --> 00:57:29,050
+limitation لهذا التأثير من خلال damage، مركبين مع
+
+799
+00:57:29,050 --> 00:57:33,350
+بعض من بعض، عمل mixing لـ two compounds، هذا بيعمل 
+
+800
+00:57:33,350 --> 00:57:38,190
+reducing the toxicity أو من خلال تقليل الوقت
+
+801
+00:57:38,190 --> 00:57:42,610
+اللازم أو وقت تعرض البويضة أو الجنين لهذه المواد،
+
+802
+00:57:42,610 --> 00:57:46,630
+للـ CPA، يعني بدل ما أخليها عشر دقائق، بخليها خمس
+
+803
+00:57:46,630 --> 00:57:52,310
+دقائق، طبعا في بعض الـ media، الـ media هي 
+
+804
+00:57:52,310 --> 00:57:56,630
+أيضا مدعومة مع micro molecule مثل polyethylene
+
+805
+00:57:56,630 --> 00:58:02,310
+glycol أو poly أو PVP، بعض الأحيان الـ media أو 
+
+806
+00:58:02,310 --> 00:58:05,090
+المواد الـ CBA التي تستخدم في الـ media بتكون
+
+807
+00:58:05,090 --> 00:58:08,410
+مخلوطة مع الـ micro molecule زي الـ PVP وهي الـ media التي 
+
+808
+00:58:08,410 --> 00:58:13,190
+استخدمت في  immobilisation of spermatozoa أو استخدام
+
+809
+00:58:13,190 --> 00:58:18,000
+polyethylene glycol، فهي عبارة عن مواد بتعمل
+
+810
+00:58:18,000 --> 00:58:21,420
+increasing للـ viscosity، the macromolecules support
+
+811
+00:58:21,420 --> 00:58:24,460
+vitrification with low concentration of CBA، هذا
+
+812
+00:58:24,460 --> 00:58:28,620
+بتعمل زيادة للـ viscosity فبالتالي بتحتل مساحة أكبر
+
+813
+00:58:28,620 --> 00:58:33,300
+بالإضافة إلى بتعمل reduction للـ toxicity level الخاصة
+
+814
+00:58:33,300 --> 00:58:38,340
+بالـ CBA، طريقة بتوضح الكلام اللي أنا قلته في الـ
+
+815
+00:58:38,340 --> 00:58:42,240
+vitrification، أول حاجة باخد البويضة أو الـ embryo
+
+816
+00:58:42,240 --> 00:58:45,960
+بعد اليوم الثالث أو بعد اليوم الرابع، بعمله
+
+817
+00:58:45,960 --> 00:58:48,980
+hybridisation أو بعمله mixing أو بعمله incubation
+
+818
+00:58:48,980 --> 00:58:53,020
+مع الـ CPA لمدة عشر دقائق أو عشرين دقيقة بناء على
+
+819
+00:58:53,020 --> 00:58:58,720
+الـ protocol المستخدة، هذه العملية بنسميها hydration
+
+820
+00:58:58,720 --> 00:59:03,720
+بعدين باخد البويضة أو الـ embryo بضيفها في منطقة
+
+821
+00:59:03,720 --> 00:59:08,140
+باسمها small amount of cryoprotectant on the
+
+822
+00:59:08,140 --> 00:59:13,780
+cryovial، بمعنى آخر أنه أنا حضنتها باخد البويضة
+
+823
+00:59:13,780 --> 00:59:19,420
+اللي موجودة في الـ Cups هذا بالـ aspiration needle 
+
+824
+00:59:19,420 --> 00:59:24,220
+بضيفها على ... في الـ catheter و بضيف عليها جزء من
+
+825
+00:59:24,220 --> 00:59:28,200
+الـ media اللي أنا استخدمتها، بعد كده باخد الـ
+
+826
+00:59:28,200 --> 00:59:31,460
+catheter اللي أنا ضفت فيها البويضة، طبعا هذا كله
+
+827
+00:59:31,460 --> 00:59:33,560
+تحت الميكروسكوب بيصير، يعني هذه العملية تحت
+
+828
+00:59:33,560 --> 00:59:36,100
+الميكروسكوب، وهذه العملية تحت الميكروسكوب الوحيدة 
+
+829
+00:59:36,100 --> 00:59:38,860
+اللي بتكون خارج الميكروسكوب عامل لإن ما بقدر أشوف 
+
+830
+00:59:38,860 --> 00:59:41,880
+الـ catheter ورفع الـ catheter والعلامة اللي ...
+
+831
+00:59:42,070 --> 00:59:47,110
+محدد أضيف فيها الـ egg أو الـ oocyte بشكل سليم، بيعمل
+
+832
+00:59:47,110 --> 00:59:52,390
+عملية removing للـ catheter وبيعملها عملية putting
+
+833
+00:59:52,390 --> 00:59:56,250
+في الـ liquid nitrogen لفترة زمنية معينة تقدر
+
+834
+00:59:56,250 --> 00:59:59,250
+بثلاثين ثانية، أربعين ثانية بناء على الـ protocol
+
+835
+00:59:59,250 --> 01:00:03,750
+المستخدم، إذا shift it into liquid nitrogen where
+
+836
+01:00:03,750 --> 01:00:09,490
+high velocity cooling or rapid cooling for the
+
+837
+01:00:09,490 --> 01:00:13,550
+oocyte enable the egg to arrive vitrification stage
+
+838
+01:00:13,550 --> 01:00:18,330
+بعد كده باخد الـ catheter هذه و بضيفه في الـ tank of 
+
+839
+01:00:18,330 --> 01:00:23,350
+liquid nitrogen لفترة زمنية اللي أنا بحتاجها for 
+
+840
+01:00:23,350 --> 01:00:26,990
+the next cycle، هذه طريقة الـ vitrification بشكل 
+
+841
+01:00:26,990 --> 01:00:30,490
+بسيط خليني أشوف الفيديو اللي بيتكلم عن هذا الموضوع
+
+842
+01:00:30,490 --> 01:00:33,850
+و كيف بتصير عملية الـ vitrification
+
+843
+01:00:56,360 --> 01:00:58,620
+طبعا الـ video notification بيكون عبارة عن زي كت
+
+844
+01:00:58,620 --> 01:01:00,020
+خاص فيها هذه الـ catheter
+
+845
+01:01:27,190 --> 01:01:32,170
+طبعا بعدد أهميتها وإيش الوظائف المطلوبة منها أو
+
+846
+01:01:32,170 --> 01:01:37,510
+كيف بتقوم بهذه العملية طبعا في منها أنواع ما
+
+847
+01:01:37,510 --> 01:01:41,470
+بيعنينا الكلام هذا كله خلينا نشوف كيف عملية
+
+848
+01:01:41,470 --> 01:01:47,270
+العملية بتصير هي بهذا الشكل بدأ عملية إخراج الـ
+
+849
+01:01:47,270 --> 01:01:53,870
+catheter أو إخراج الـ strip خليني أسميه بضيف الـ
+
+850
+01:01:53,870 --> 01:01:58,030
+Label عليها علشان ما يصير عملية interference في
+
+851
+01:01:58,030 --> 01:02:08,090
+البيانات الـ ID الـ forceps بيخرج جزء منها طبعاً 
+
+852
+01:02:08,090 --> 01:02:13,550
+بحطها في الـ Liquid nitrogen تحت
+
+853
+01:02:13,550 --> 01:02:19,070
+الميكروسكوب هياخد قلب ويده هيضيفها ويعملها holding
+
+854
+01:02:19,070 --> 01:02:24,270
+على الـ strip الموجود أو الـ Straw في بعض الأحيان
+
+855
+01:02:24,270 --> 01:02:28,070
+بيسموها طبعا في لمكان محدد هذي بيسموها الزرجة
+
+856
+01:02:28,070 --> 01:02:33,910
+بيسموها الـ Straw أو الـ Strip بعد
+
+857
+01:02:33,910 --> 01:02:43,730
+كده لازم يعمل عملية إدخال للمحتوى في داخل و بلفها 
+
+858
+01:02:43,730 --> 01:02:49,070
+عشان يسكرها كده عمل vitrification ببساطة جدا كيف
+
+859
+01:02:49,070 --> 01:02:50,070
+بيعملها warming؟
+
+860
+01:02:55,240 --> 01:03:00,540
+عشان يعمل flowing يعني طبعا 
+
+861
+01:03:00,540 --> 01:03:05,840
+في الـ liquid nitrogen بيلفها لف عكسي علشان يفكها و
+
+862
+01:03:05,840 --> 01:03:09,260
+بيسحبها وبنتظر شوية في الـ liquid nitrogen عشان
+
+863
+01:03:09,260 --> 01:03:13,980
+ما يصير الشكلها وبعدين بنقلها على الـ media الخاصة
+
+864
+01:03:13,980 --> 01:03:17,080
+فيها عشان كده الـ vitrification تعتبر أسهل الطرق
+
+865
+01:03:17,080 --> 01:03:20,080
+التي تستخدمها مقارنة بسيطة بين الـ slow freezing و
+
+866
+01:03:20,080 --> 01:03:23,060
+الـ vitrification الـ damage بيصير في الـ low
+
+867
+01:03:23,060 --> 01:03:26,300
+freezing مافيش في الـ vitrification دمج ل الـ oocyte
+
+868
+01:03:26,300 --> 01:03:29,680
+من خلال تكوين الـ ice crystal الـ speed of freezing
+
+869
+01:03:29,680 --> 01:03:37,020
+تقدر بـ 0.3 درجة
+
+870
+01:03:37,020 --> 01:03:40,100
+لكل minute في الـ slow freezing والـ vitrification
+
+871
+01:03:40,100 --> 01:03:43,940
+بتصل لـ 23 درجة لكل دقيقة بيصير reduction في الـ
+
+872
+01:03:43,940 --> 01:03:48,270
+temperature الـ Pre-protectant amounted very low،
+
+873
+01:03:48,270 --> 01:03:51,370
+very high في الـ vitrification، الـ survival rate
+
+874
+01:03:51,370 --> 01:03:56,070
+very low في الـ slow freezing، في الـ vitrification
+
+875
+01:03:56,070 --> 01:03:58,830
+عالية، الـ procedure very simple في الـ slow
+
+876
+01:03:58,830 --> 01:04:02,390
+freezing، في الـ vitrification complex، لأنها
+
+877
+01:04:02,390 --> 01:04:07,490
+بتعتمد على الدقة والتركيز بشكل كبير جدا طبعا الـ
+
+878
+01:04:07,490 --> 01:04:10,930
+duration تأخد second الـ vitrification slow
+
+879
+01:04:10,930 --> 01:04:14,190
+freezing ممكن تأخد ساعات control of dehydration
+
+880
+01:04:14,190 --> 01:04:16,910
+rate موجودة في الـ vitrification مش موجودة في الـ
+
+881
+01:04:16,910 --> 01:04:20,750
+slow freezing الـ duration out of incubator عشرة
+
+882
+01:04:20,750 --> 01:04:22,950
+دقائق في الـ vitrification تلاتة hour في الـ slow
+
+883
+01:04:22,950 --> 01:04:27,050
+freezing زونة في الـ oocyte تصير تدمير في الـ
+
+884
+01:04:27,050 --> 01:04:30,790
+vitrification لأ في الـ slow freezing maybe الـ
+
+885
+01:04:30,790 --> 01:04:33,950
+equipment and running cost inexpensive في الـ
+
+886
+01:04:33,950 --> 01:04:38,250
+vitrification very expensive تحتاج إلى machine الـ
+
+887
+01:04:38,250 --> 01:04:42,050
+slow freezing في هذا القدر نكون قد أنهينا هذه
+
+888
+01:04:42,050 --> 01:04:47,230
+المحاضرة وأنهينا إلى حد ما معظم الـ topics اللي
+
+889
+01:04:47,230 --> 01:04:51,350
+احنا اتوقعنا وكنا نحكي عليها خلال هذه المحاضرة
+
+890
+01:04:51,350 --> 01:04:56,550
+نرجو لكم التوفيق دائما ودمتم في حفظنا ورعايتنا 
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/dsOa0-DLeoA_postprocess.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/dsOa0-DLeoA_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..4d6ea0305be2b41d461e3b60818f1366d6a9b6cf
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/dsOa0-DLeoA_postprocess.srt
@@ -0,0 +1,3560 @@
+1
+00:00:01,080 --> 00:00:05,080
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:05,080 --> 00:00:10,620
+المرسلين سيدنا محمد وعلى آله وصحبه أجمعين طلابنا
+
+3
+00:00:10,620 --> 00:00:14,900
+الأفاضل نرجو من الله أن تكونوا جميعا بخير وبصحة
+
+4
+00:00:14,900 --> 00:00:19,860
+جيدة اليوم سوف ننتقل إلى chapter جديد يتحدث عن ال
+
+5
+00:00:19,860 --> 00:00:24,260
+embryo transfer and implantation سوف نتحدث في هذا
+
+6
+00:00:24,260 --> 00:00:29,020
+ال chapter عن آلية نقل ال embryo ما هو الجنين الذي
+
+7
+00:00:29,020 --> 00:00:34,260
+ينقلكيف يكون تقييم الجنين بناء على الضوابط المعمول
+
+8
+00:00:34,260 --> 00:00:38,060
+فيها في مختبرات التلقيح الصناعي؟ ما معنى
+
+9
+00:00:38,060 --> 00:00:41,900
+implantation؟ كيف تحدث عملية الـ implantation؟
+
+10
+00:00:41,900 --> 00:00:45,000
+بالإضافة إلى الانتقال إلى موضوع الـ
+
+11
+00:00:45,000 --> 00:00:49,820
+cryopreservation كان مبدأ مختصرا بسيطا عن آلية
+
+12
+00:00:49,820 --> 00:00:54,160
+تجميد الأجنة وتجميد البويضات طبعا هذا ال chapter
+
+13
+00:00:54,160 --> 00:00:57,760
+هيكون هو ال chapter الأخير في هذا المصاق ان شاء
+
+14
+00:00:57,760 --> 00:01:03,450
+اللهنبدأ على بركة الله بداية عملية ال implantation
+
+15
+00:01:03,450 --> 00:01:08,930
+ببساطة جدا هي عبارة عن عملية يتم فيها انغراس
+
+16
+00:01:08,930 --> 00:01:13,830
+الجنين المنقول بعد عملية التلقيح التي حدثت في
+
+17
+00:01:13,830 --> 00:01:19,310
+المختبر إلى رحم الأنثى أو رحم السيدة هذا الانغراس
+
+18
+00:01:19,310 --> 00:01:23,930
+يؤدي إلى تشابك ما بين الجنين وبين ال endomaterial
+
+19
+00:01:23,930 --> 00:01:28,070
+service الموجودة في رحم السيدة وهي التي تعرف باسم
+
+20
+00:01:28,370 --> 00:01:33,110
+بقنط الرحم مما يؤدي في النهاية إلى تكوين لبلاسنتا
+
+21
+00:01:33,110 --> 00:01:36,730
+التي تكون عبارة عن حلقة الوصل ما بين الدورة
+
+22
+00:01:36,730 --> 00:01:40,690
+الدموية الخاصة بالجنين والدورة الدموية الخاصة
+
+23
+00:01:40,690 --> 00:01:45,760
+بالأم والتي تكون بمثابة البوابةالتي من خلالها يحدث
+
+24
+00:01:45,760 --> 00:01:49,740
+تبادل المواد الغذائية التي يحتاج إليها الجنين
+
+25
+00:01:49,740 --> 00:01:54,780
+بالإضافة إلى الوكسوجين وخلافه كما نعرف بلاسنتا
+
+26
+00:01:54,780 --> 00:01:58,900
+that will provide an interference between growing
+
+27
+00:01:58,900 --> 00:02:02,120
+fetus and maternal circulation the human
+
+28
+00:02:02,120 --> 00:02:06,640
+endomaterium undergo a complex series of organized
+
+29
+00:02:07,790 --> 00:02:12,870
+هذه الـ endomaterium الموجودة في الرحم و التي سميت
+
+30
+00:02:12,870 --> 00:02:17,750
+بالنقطة الرحم خلال عملية ال ovulation إذا بدأنا من
+
+31
+00:02:17,750 --> 00:02:22,690
+البداية مرورا ب fertilization إذا كان الأمر طبيعي
+
+32
+00:02:22,690 --> 00:02:27,690
+تخضع إلى العديد من التغيرات التي تجعل خلايا ال
+
+33
+00:02:27,690 --> 00:02:33,510
+endomaterium أكثر نموأكثر سماكة، أكثر تقبلًا
+
+34
+00:02:33,510 --> 00:02:39,370
+لإستقبال الجنين الذي سوف ينغرس في هذه البطانة مما
+
+35
+00:02:39,370 --> 00:02:44,110
+يؤدي إلى تكوين الـ placenta التي تكون ناشع عن وجود
+
+36
+00:02:44,110 --> 00:02:49,070
+جنين جديد تم انغراسه في منطقة البطانة الرحلة هذه
+
+37
+00:02:49,070 --> 00:02:53,710
+التغيرات ممكن تكون تغيرات لها علاقة بكمية blood
+
+38
+00:02:53,710 --> 00:02:57,390
+supply التي تصل إلى هذه المنطقة كمية البوتينات
+
+39
+00:02:57,390 --> 00:03:01,410
+التي تفرزكمية الـ Transporter Material أو الـ
+
+40
+00:03:01,410 --> 00:03:04,590
+Transporter Protein التي تبدأ في المهاجرة إلى هذا
+
+41
+00:03:04,590 --> 00:03:09,630
+المكان بالإضافة إلى كمية الغرمونات التي تفرز بحدد
+
+42
+00:03:09,630 --> 00:03:14,510
+معين من أجل المساهمة في بناء بطاقة الرحم ومن أجل
+
+43
+00:03:14,510 --> 00:03:18,230
+المساهمة في إنجاح عملية ال implantation فبالتالي
+
+44
+00:03:18,230 --> 00:03:23,870
+هذه العملية عملية مهمة جدا عملية نمو بطاقة الرحم
+
+45
+00:03:23,870 --> 00:03:26,970
+فبالتالي عملية الانغراس أو عملية ال implantation
+
+46
+00:03:27,220 --> 00:03:32,520
+ليس عملية عشوائية تحدث بسبب فعل واحد أو حدث واحد
+
+47
+00:03:32,520 --> 00:03:37,100
+إنما هي عبارة عن أحداث متراكمة تؤدي في النهاية إلى
+
+48
+00:03:37,100 --> 00:03:41,320
+حدوث ال implantation in a human during normal
+
+49
+00:03:41,320 --> 00:03:45,060
+cycle for example ال embryo will be enter in the
+
+50
+00:03:45,060 --> 00:03:49,580
+uterine cavity in the four day after ovulation في
+
+51
+00:03:49,580 --> 00:03:53,330
+الوضع الطبيعيإذا صار عندى fertilization طبيعي
+
+52
+00:03:53,330 --> 00:03:57,450
+المفروض ال embryo إذا تم تلقيحه بشكل طبيعي في قناة
+
+53
+00:03:57,450 --> 00:04:02,010
+Fallopian tube هيصل إلى الرحل بعد أربع أيام من
+
+54
+00:04:02,010 --> 00:04:06,750
+عملية ال ovulation عشان كده حكينا إن البويضة
+
+55
+00:04:06,750 --> 00:04:11,430
+تستغرط تلت أيام كحد أقصى علشان تقطع منطقة ال
+
+56
+00:04:11,430 --> 00:04:16,730
+fallopian tube وصولا إلى اليوتران وعلشان كده حكينا
+
+57
+00:04:16,730 --> 00:04:22,120
+إنهعملية إرجاع الأجنة في عملية الحقن المجهري تحدث
+
+58
+00:04:22,120 --> 00:04:27,140
+بعد تلت أيام كحد أدنى أو خمس أيام كحد أقصى إذا
+
+59
+00:04:27,140 --> 00:04:30,540
+بتتذكر اللغة اللي حكينا عن الـBGD كانت بيصير
+
+60
+00:04:30,540 --> 00:04:35,580
+embryo transfer ال
+
+61
+00:04:35,580 --> 00:04:38,600
+endomaterium become receptive
+
+62
+00:04:41,190 --> 00:04:47,430
+أقل من 6 أيام بعد الوفيوليشيا ويبقى مستمع ل 4 أيام
+
+63
+00:04:47,430 --> 00:04:54,730
+سيكل 22-24 أي دورة شهرية أبيعية منتظمة عند السيدة
+
+64
+00:04:54,730 --> 00:04:59,890
+معناه أن الهندو ماتيريام هتكون قابلة لاستقبال و
+
+65
+00:04:59,890 --> 00:05:03,010
+قادرة على استقبال لبلاستوسيست وهي عبارة عن
+
+66
+00:05:03,010 --> 00:05:06,050
+الامبريو بعد ما اتحول من موريلا إلى بلاستوسيست
+
+67
+00:05:06,050 --> 00:05:13,320
+خلال 6 أيام على الأقل بعد الوفيوليشيابينما تبقى
+
+68
+00:05:13,320 --> 00:05:17,160
+بعد 6 أيام قادرة على استقبال الجنين حتى 4 أيام،
+
+69
+00:05:17,160 --> 00:05:21,320
+يعني بمعنى آخر تستطيع الـ endomaterial أن تحتفظ
+
+70
+00:05:21,320 --> 00:05:28,080
+بقابلتها لاستقبال الجنين من 6 إلى 4 أيام، total
+
+71
+00:05:28,080 --> 00:05:32,650
+عشر أيام من لحظة الوفيولوجياعشان كده حكينا إنه في
+
+72
+00:05:32,650 --> 00:05:36,950
+ال XE أو ال IVF عملية ال import transfer ممكن تحدث
+
+73
+00:05:36,950 --> 00:05:39,990
+في اليوم التاني و التالت و الرابع و الخامس و
+
+74
+00:05:39,990 --> 00:05:44,270
+السادس طبعا هذا إيش بتحكم فيها؟ بتحكم عدد الخلايا
+
+75
+00:05:44,270 --> 00:05:48,230
+اللي انقسمت داخل الجنين متى وصلت إلى مرحلة ال
+
+76
+00:05:48,230 --> 00:05:53,150
+plasticest هل تحتاج إلى عمل PGD ولا لأ؟ ماء ان
+
+77
+00:05:53,150 --> 00:05:56,770
+طبيعة الفحوصات الوراثية اللتي سوف تحدث على هذا
+
+78
+00:05:56,770 --> 00:06:00,750
+الجنينهل تستغرق وقت طويل؟ يومين، تلاتة؟ فبالتالي
+
+79
+00:06:00,750 --> 00:06:06,930
+أنا هنتظر نتيجة ظهور الـBGD as genetic testing
+
+80
+00:06:06,930 --> 00:06:10,270
+وبناء عليه أقرر أرجع أي جنين عشان كده ممكن أرجع
+
+81
+00:06:10,270 --> 00:06:13,090
+الجنين في اليوم الخامس، في اليوم السادس فسبحان
+
+82
+00:06:13,090 --> 00:06:16,710
+الله أن الـEndometrium لها قابلية أن تستقبل جنين
+
+83
+00:06:16,710 --> 00:06:20,170
+لمدة ست أيام، ست أيام بالضبط بعد الـovulation
+
+84
+00:06:20,170 --> 00:06:24,530
+واضيف عليهم كمان أربع أيام اضيف عليهم كمان أربع
+
+85
+00:06:24,530 --> 00:06:27,390
+أيام when implantation does not occurمافي
+
+86
+00:06:27,390 --> 00:06:30,610
+implantation صار fertilization ومافي implantation
+
+87
+00:06:30,610 --> 00:06:34,850
+ماصار fertilization معناه انه خلاص ال endomaterium
+
+88
+00:06:34,850 --> 00:06:38,250
+هتبدأ عملية ال destruction و we are removing as
+
+89
+00:06:38,250 --> 00:06:42,330
+bleeding تحت مصطلح الدورة او ال menstrual cycle
+
+90
+00:06:42,330 --> 00:06:46,390
+هذا اللي بيصير في وضعه الطبيعي طيب السؤال هل ال
+
+91
+00:06:46,390 --> 00:06:50,430
+implantation تحدث بشكل عابر؟ هل ال implantation
+
+92
+00:06:50,430 --> 00:06:55,180
+تحدث بفعل حدث واحد ام احداث متتالية؟To achieve
+
+93
+00:06:55,180 --> 00:06:58,900
+successful implantation, the uterus should undergo
+
+94
+00:06:58,900 --> 00:07:02,660
+structural and functional remodeling يعني معناها
+
+95
+00:07:02,660 --> 00:07:07,020
+إنه لازم أنا أهيأ الرحم للتغيرات الفيسيولوجية
+
+96
+00:07:07,020 --> 00:07:11,710
+والوظيفية المطلوبةالتمدد مثلًا، تسارع عملية انقصام
+
+97
+00:07:11,710 --> 00:07:15,410
+الخلايا، زيادة الـBlood supply، زيادة مستوى
+
+98
+00:07:15,410 --> 00:07:18,650
+الهرمونات المعينة زي الـ Progesterone عشان كده
+
+99
+00:07:18,650 --> 00:07:23,310
+حكينا بعد الـ IG بعد عملية الـ Improtransfer في
+
+100
+00:07:23,310 --> 00:07:26,530
+الـ Agonist و الـ Antagonist الزوجة أو المرأة
+
+101
+00:07:26,530 --> 00:07:30,010
+تُعطى Progesterone عن طريق الـ cervical من أجل
+
+102
+00:07:30,010 --> 00:07:35,070
+تحفيز زيادة أو من أجل تحفيز وزيادة معدل نمو
+
+103
+00:07:35,070 --> 00:07:39,430
+الخلايا المبطنة للرحمومن أجل تثبيت الجنين ومن أجل
+
+104
+00:07:39,430 --> 00:07:43,850
+المساعدة في زيادة فرصة الـ implantation أثناء
+
+105
+00:07:43,850 --> 00:07:48,790
+عملية تاريجية الأجنة الملقحة أو التي خلقت ..
+
+106
+00:07:48,790 --> 00:07:51,610
+خلّينا نسميها .. أو التي نتجت من التلقيح الصناعي
+
+107
+00:07:51,610 --> 00:07:55,970
+في المختبر الاستروجين و البروجسترون هم الهرمون
+
+108
+00:07:55,970 --> 00:08:02,990
+المعروف هذا الهرمون سيفعلpoint and rule in this
+
+109
+00:08:02,990 --> 00:08:07,090
+step or in this function وهي structural and
+
+110
+00:08:07,090 --> 00:08:11,210
+functional remodeling of uterus فبالتالي عند
+
+111
+00:08:11,210 --> 00:08:14,170
+الاستروجين و البروجيسترون هما الأشهر الغرمونات
+
+112
+00:08:14,170 --> 00:08:19,330
+اللتي تلعب دورة مهمة و أساسيا و فعالة لعملية تهيئ
+
+113
+00:08:19,330 --> 00:08:24,550
+الرحم لاستقبال الجنين البروجيسترون أيضا بيلعب دورة
+
+114
+00:08:24,550 --> 00:08:27,950
+رئيسية في عملية إنجاح ال implantation من خلال
+
+115
+00:08:27,950 --> 00:08:33,730
+تدعيم وزيادة معدل نمو الأجنةبالإضافة إلى زيادة أو
+
+116
+00:08:33,730 --> 00:08:38,370
+تدايم نمو وتطور الجنين لكي يصل إلى المرحلة
+
+117
+00:08:38,370 --> 00:08:42,050
+المقلوبة التي تساهم في عملية ال implantation في ال
+
+118
+00:08:42,050 --> 00:08:44,550
+follicular phase is under influence of rising
+
+119
+00:08:44,550 --> 00:08:48,010
+estrogen level due to growing ovarian follicle إذا
+
+120
+00:08:48,010 --> 00:08:51,450
+بنرجع بالذاكرة لل chapter 2 قلنا فيه عندى .. أو ال
+
+121
+00:08:51,450 --> 00:08:53,710
+chapter 2 فيه عندى ال follicular phase و ال
+
+122
+00:08:53,710 --> 00:08:56,430
+follicular phase هو عبارة عن الطور اللي تبدأ
+
+123
+00:08:56,430 --> 00:09:00,670
+البويضة في النضوجفلوكيلة بالنضوج يعني البويضة
+
+124
+00:09:00,670 --> 00:09:04,910
+بالنضوج بداخلها نضوج البويضة معناه إفراز هرمون
+
+125
+00:09:04,910 --> 00:09:10,190
+الاستروجين الذي يرسل إشارة إلى الرحم و لخلايا
+
+126
+00:09:10,190 --> 00:09:12,790
+الرحم أي الخلايا المبطلة للرحم اللي سميتها
+
+127
+00:09:12,790 --> 00:09:17,910
+endomateria من أجل البدء في الإنقسام والتضاعف
+
+128
+00:09:17,910 --> 00:09:24,430
+لتهيئة الرحم لاستقبال بويضة مخصبة إن حدث التخسيب
+
+129
+00:09:24,430 --> 00:09:29,230
+لذلك يقول إن الاستروجينأيضًا دورهم خلال
+
+130
+00:09:29,230 --> 00:09:34,150
+الـFollicular phase لتو Proliferation of
+
+131
+00:09:34,150 --> 00:09:38,230
+epithelium stroma and vascular endothelium to
+
+132
+00:09:38,230 --> 00:09:42,800
+cause regeneration of the endomaterialعرفت ايه وش
+
+133
+00:09:42,800 --> 00:09:46,720
+وظيفة الاستروجين و اين يفرز الاستروجين اعمل
+
+134
+00:09:46,720 --> 00:09:50,260
+flashback لل chapter التاني او التالت هنعرف ان
+
+135
+00:09:50,260 --> 00:09:54,460
+الاستروجين يفرز من البويضة او من ال filicular التي
+
+136
+00:09:54,460 --> 00:09:59,020
+تبدأ بالنضوج و كل ما زاد عدد البويضات الناضجة زاد
+
+137
+00:09:59,020 --> 00:10:02,640
+مستوى الاستروجين علشان كده قلنا ان الاستروجين
+
+138
+00:10:02,640 --> 00:10:06,780
+يعتبر احد ال indicator التي تستخدم للتعرف على عدد
+
+139
+00:10:06,780 --> 00:10:11,630
+البويضات التي قد تنضج مستقبلاما هو وظيفته في عملية
+
+140
+00:10:11,630 --> 00:10:15,290
+الـ Implantation؟ إنه يرسل إسشارة إلى الـUterus
+
+141
+00:10:15,290 --> 00:10:19,930
+إنه تبدأ خلايا بطاقة الرحم تنمو وتضاعف وتتكثر من
+
+142
+00:10:19,930 --> 00:10:25,430
+أجل تهيئ الرحم لإستقبال جنين جديد أو بوادة مخصرة
+
+143
+00:10:25,430 --> 00:10:33,530
+الـ Estrogen can induce Uterine طبعا ال Estrogen
+
+144
+00:10:33,530 --> 00:10:38,330
+أيضا بلعب دور في زيادة قابلية الرحم إن يستقبل هذه
+
+145
+00:10:38,330 --> 00:10:45,570
+البوادة من خلالحاكنها في مصابة من خلال زيادة معدل
+
+146
+00:10:45,570 --> 00:10:49,750
+مضوج الخلايا زيادة blood supply remaining open for
+
+147
+00:10:49,750 --> 00:10:54,730
+extended period at lower estrogen level يعني مش بس
+
+148
+00:10:54,730 --> 00:10:59,430
+انه بيزيد معدل استقبال او معدل نموب و تكاثر
+
+149
+00:10:59,430 --> 00:11:03,390
+الخلايا لأ انه بيعمل extension لعدد الايام اللتي
+
+150
+00:11:03,390 --> 00:11:07,450
+تسمحلبيطانة الرحم باستقبال الجنين اللي احنا قلناها
+
+151
+00:11:07,450 --> 00:11:11,890
+اربع أيام اضافية رغم انه فيه ست أيام اربع ايام
+
+152
+00:11:11,890 --> 00:11:14,370
+اضافية بفعل ال E2
+
+153
+00:11:16,840 --> 00:11:22,620
+أيضًا بالنسبة للأستروجين level is improved when
+
+154
+00:11:22,620 --> 00:11:24,860
+estrogen levels are decreased during pre
+
+155
+00:11:24,860 --> 00:11:27,960
+-implantation period and patients undergo in vitro
+
+156
+00:11:27,960 --> 00:11:32,480
+fertilization مهم جدًا من أجل زيادة وتحسين قدرة
+
+157
+00:11:32,480 --> 00:11:36,820
+الرحم على استقبال البويضة المخصبة لإيصال reduction
+
+158
+00:11:36,820 --> 00:11:41,180
+للأستروجين مايعني reduction للأستروجين؟ معنى
+
+159
+00:11:41,180 --> 00:11:44,200
+reduction للأستروجين يعني مستوى الأستروجين يقل
+
+160
+00:11:44,410 --> 00:11:50,090
+معناه الجسم بيفهم تلقائيا ان الفوليكلر انفجرت وصار
+
+161
+00:11:50,090 --> 00:11:54,530
+ovulation يعني البويضة قد تكونقُصّبت فبالتالي
+
+162
+00:11:54,530 --> 00:11:57,190
+عملية الـFollicular phase وعملية الـ ovulation
+
+163
+00:11:57,190 --> 00:12:01,410
+انتهت منها انتهى الجسم منها يعني بتبدأ بمرحلة
+
+164
+00:12:01,410 --> 00:12:05,170
+جديدة وهي استقبال الجنين تحت مصطلح implantation
+
+165
+00:12:05,170 --> 00:12:08,310
+فبالتالي الاستروجين لازم يجل في هذه الفترة وإلا
+
+166
+00:12:08,310 --> 00:12:13,670
+إذا دلوا مرتفع معناه لسه ما صار في عندي الوصول
+
+167
+00:12:13,670 --> 00:12:16,710
+لدرجة النضوج البويضة معناه ما صار في عندي
+
+168
+00:12:16,710 --> 00:12:28,610
+ovulation لأ بالراحةالتي كانت
+
+169
+00:12:28,610 --> 00:12:34,070
+مفروض تكون صارها operation حاليا الـ early embryo
+
+170
+00:12:34,070 --> 00:12:38,430
+entered the uterine cavity as morela and become 32
+
+171
+00:12:38,430 --> 00:12:43,810
+to 265
+
+172
+00:12:43,810 --> 00:12:48,250
+65 cell blastocyst before implantation بمعنى آخرإن
+
+173
+00:12:48,250 --> 00:12:53,170
+الـ embryo ممكن يصل و يدخل تجويف الرحم يا إما على
+
+174
+00:12:53,170 --> 00:12:57,970
+شكل موريلا أو على شكل بلاستوست عدد خليها تصل إلى
+
+175
+00:12:57,970 --> 00:13:06,510
+2256 خلية موريلا أو بلاستوست والأكثر بلاستوست
+
+176
+00:13:06,510 --> 00:13:09,230
+Implantation beginning with the loss of zona
+
+177
+00:13:09,230 --> 00:13:12,750
+pellucida none of hatching as we know about one to
+
+178
+00:13:12,750 --> 00:13:16,290
+three day after موريلا entered the uterineCavity
+
+179
+00:13:16,290 --> 00:13:19,490
+in the preparation of attachment يعني عملية ال
+
+180
+00:13:19,490 --> 00:13:23,850
+implantation تبدأ بدخول الجنين في مرحلة الموريلا
+
+181
+00:13:23,850 --> 00:13:32,650
+إلى ال cavity الخاص برحم السيدة ثم تبدأ ال zona
+
+182
+00:13:32,650 --> 00:13:39,310
+pellucida باتهتك أو انقسم أو التقشر أو الإزالةهذا
+
+183
+00:13:39,310 --> 00:13:43,670
+تقريبا بياخد يوم إلى تلت أيام بعد دخول الموريلا
+
+184
+00:13:43,670 --> 00:13:48,250
+الوريتان كافيتي بعد كده بتبدأ عملية ال attachment
+
+185
+00:13:48,250 --> 00:13:52,190
+مع ال endomateria يعني تلت نقاط أساسية دخول
+
+186
+00:13:52,190 --> 00:13:58,930
+الموريلا او ال embryo از موريلا face لتجويف الرحم
+
+187
+00:13:58,930 --> 00:14:03,570
+ازالة وتهتك ال zona pellucida والبدء في عملية ال
+
+188
+00:14:03,570 --> 00:14:06,450
+attachment مع ال endomateriaعشان كده قسموا الـ
+
+189
+00:14:06,450 --> 00:14:09,950
+Implantation إلى تلت مقاطع أو تلت أطوار الطور
+
+190
+00:14:09,950 --> 00:14:13,690
+الأول بيسموه Opposition و الطور التاني بيسموه
+
+191
+00:14:13,690 --> 00:14:16,830
+Adhesion و الطور التالت بيسموه Invasion ال
+
+192
+00:14:16,830 --> 00:14:19,890
+Opposition بيصير فيه عند Plastocyst contact the
+
+193
+00:14:19,890 --> 00:14:22,290
+implantation site of the endomaterium يعني الـ
+
+194
+00:14:22,290 --> 00:14:25,290
+Plastocyst بتتصل بالمكات اللي المفروض بيصير فيه
+
+195
+00:14:25,290 --> 00:14:28,010
+Implantation بيسموه Opposition بعدين ال Adhesion
+
+196
+00:14:28,010 --> 00:14:33,480
+إن الـTrophoplast cellof the plastocyst تتصل مع
+
+197
+00:14:33,480 --> 00:14:36,880
+الـ endomaterium بعدين بيصير عندي invasion وهي
+
+198
+00:14:36,880 --> 00:14:41,040
+عبارة عن الانغماس أو الانغراس ان البلاستوست جميع
+
+199
+00:14:41,040 --> 00:14:45,500
+خلاياها تبدأ تتشابك مع ال endomaterium وتصبح جزء
+
+200
+00:14:45,500 --> 00:14:48,980
+لا يتجزأ منها هل بنسميها invasion انغراس
+
+201
+00:14:48,980 --> 00:14:50,820
+opposition
+
+202
+00:14:52,700 --> 00:14:55,160
+and adhesion implantation beginning with the
+
+203
+00:14:55,160 --> 00:14:57,900
+apposition of the blastocyst at the uterine and
+
+204
+00:14:57,900 --> 00:15:01,040
+epithelium generally about two to four days after
+
+205
+00:15:01,040 --> 00:15:04,920
+Morella entered the uterine cavity يعني بيقوللي ان
+
+206
+00:15:04,920 --> 00:15:08,220
+ال opposition و ال adhesion الخاصة بال
+
+207
+00:15:08,220 --> 00:15:12,600
+implantation على أساس أنهم أول حدثين بتبدأ من
+
+208
+00:15:12,600 --> 00:15:16,080
+اليوم التاني إلى اليوم الرابع بعد يعني عد يومين
+
+209
+00:15:16,080 --> 00:15:20,840
+إلى أربع أيام بعد دخول الموريلا إلى تجوف الرحمالـ
+
+210
+00:15:20,840 --> 00:15:24,700
+Implantation is considered العلماء صنفوا الـ
+
+211
+00:15:24,700 --> 00:15:30,040
+Implantation على إنها ظاهرة تسمى Pro-inflammatory
+
+212
+00:15:30,040 --> 00:15:33,870
+reactionطب ليه سموها بهذا الشكل؟ لإنه بيصير عندي
+
+213
+00:15:33,870 --> 00:15:39,090
+vasovascular permeability is marked increased at
+
+214
+00:15:39,090 --> 00:15:42,830
+the attachment site mediated by cyclooxygenase
+
+215
+00:15:42,830 --> 00:15:46,090
+derivative prostaglandin لإنه بيصير عندي شغلة شغل
+
+216
+00:15:46,090 --> 00:15:49,670
+الأولى زيادة النفازية الخاصة بالأواع الدموية مما
+
+217
+00:15:49,670 --> 00:15:54,170
+يؤدي إلى زيادة ضفق الدم للمكان الذي انغرص فيه
+
+218
+00:15:54,170 --> 00:15:58,830
+الجنين الشغلة التانية إفراز بعض المكونات الأساسية
+
+219
+00:15:58,830 --> 00:16:02,750
+التي تلعب دور كبير جداالتي تعمل على زيادة الضفف
+
+220
+00:16:02,750 --> 00:16:05,550
+قدامه و زيادة الدورة الدموية زي ال prostaglandin
+
+221
+00:16:05,550 --> 00:16:10,010
+اللي يسمونه coax prostaglandin او cyclooxygenase
+
+222
+00:16:12,810 --> 00:16:15,850
+Prostaglandin E2 هذا الكلام أخدناه تقريبا في
+
+223
+00:16:15,850 --> 00:16:19,710
+الشبتر الأول والشبتر التاني عرّجنا عليه بشكل بسيط
+
+224
+00:16:19,710 --> 00:16:23,350
+انه يقول برستاجلاندين E2 is increased in the
+
+225
+00:16:23,350 --> 00:16:27,310
+luminal epithelium and the underlying stroma at
+
+226
+00:16:27,310 --> 00:16:30,230
+the human implantation site يعني بيبدأ يزيد في
+
+227
+00:16:30,230 --> 00:16:33,890
+المنطقة اللي صار فيها implantation those indicate
+
+228
+00:16:33,890 --> 00:16:36,770
+its role in the attached and localized
+
+229
+00:16:36,770 --> 00:16:40,520
+endomaterium vascular permeabilityيعني
+
+230
+00:16:40,520 --> 00:16:45,340
+البروستاجلاندين E2 أول زياداته تكمن في المنطقة
+
+231
+00:16:45,340 --> 00:16:48,600
+اللي صار فيها attachment وإن البلاستوست عملت
+
+232
+00:16:48,600 --> 00:16:52,420
+attachment مع الـendomaterium يبدأ البروستاجلاندين
+
+233
+00:16:52,420 --> 00:16:56,420
+بالانفراز والخروج في هذه المنطقة طب إيش وظيفته؟
+
+234
+00:16:56,420 --> 00:17:00,140
+وظيفته بشكل أساسي Indicating its role in the
+
+235
+00:17:00,140 --> 00:17:03,340
+attachment and localized endomaterium vascular
+
+236
+00:17:03,340 --> 00:17:07,900
+permeability بحدد مكان ال attachment ما بين
+
+237
+00:17:07,900 --> 00:17:11,880
+البلاستوستوالـ endomateria مما يؤدي إلى زيادة
+
+238
+00:17:11,880 --> 00:17:15,960
+النفاذية الدموية لهذه المنطقة يعني زيادة الدور
+
+239
+00:17:15,960 --> 00:17:18,600
+الدموية وضخ الدم في هذه المنطقة اللي صار فيها
+
+240
+00:17:18,600 --> 00:17:23,400
+attachment during a position process, the placenta
+
+241
+00:17:23,400 --> 00:17:27,480
+differs into inner cell embryo and trophoectoderm
+
+242
+00:17:27,480 --> 00:17:30,770
+placentaخلال هذه العملية، وهي الخطوة الأولى من
+
+243
+00:17:30,770 --> 00:17:34,370
+عملية الـ Implantation لـ Plastocyst بتم فيها
+
+244
+00:17:34,370 --> 00:17:37,730
+عملية التمايز إلى two parts ال part الداخل اللي
+
+245
+00:17:37,730 --> 00:17:40,750
+بيسميها inner cell mass وهي عبارة عن إمبريو وال
+
+246
+00:17:40,750 --> 00:17:44,250
+part الخارجي وهي trophoectoderm اللي بيسميها
+
+247
+00:17:44,250 --> 00:17:48,770
+Placenta اللي بتكوّل لـ Placenta فيما بعدطبعا بعد
+
+248
+00:17:48,770 --> 00:17:52,830
+الحدثان الأول ال opposition بصير الحدث تاني وهو ال
+
+249
+00:17:52,830 --> 00:17:56,630
+adhesion stage و ال adhesion stage في الغالب in
+
+250
+00:17:56,630 --> 00:17:59,270
+which the association of trophoplast and the
+
+251
+00:17:59,270 --> 00:18:02,430
+luminal epithelia is strong enough to resist
+
+252
+00:18:02,430 --> 00:18:07,610
+delocalization of blastocyst by flushing the
+
+253
+00:18:07,610 --> 00:18:11,790
+uterine lumina بمعنى آخر أن هذا ال stage اللي سمته
+
+254
+00:18:11,790 --> 00:18:16,830
+adhesion مهم جدا لأنه بيلعب دور كبير جدا في تثبيت
+
+255
+00:18:17,360 --> 00:18:21,300
+الـ embryo في هذا المكان ومنع ال embryo من عملية
+
+256
+00:18:21,300 --> 00:18:24,760
+تغيير مكان يعني بيخلّيه resistant for this
+
+257
+00:18:24,760 --> 00:18:28,700
+location ما بيخلّيه يغير مكانه لأنه إذا صار
+
+258
+00:18:28,700 --> 00:18:31,760
+adhesion معناه الخطوة التانية ال invasion مهمة جدا
+
+259
+00:18:31,760 --> 00:18:37,040
+حتصير بدون adhesion معناه مافي عندي invasion طبعا
+
+260
+00:18:37,040 --> 00:18:41,380
+هذا ال stage اللي سمته adhesion بياخد ما يقارب من
+
+261
+00:18:41,380 --> 00:18:48,260
+20 إلى 21 يومومهم جدا في زيادة استمرارية تضافق
+
+262
+00:18:48,260 --> 00:18:51,720
+الدم إلى المكان اللي صار فيه attachment بعدين
+
+263
+00:18:51,720 --> 00:18:54,860
+بييجي بعد ال adhesion مرحلة أخرى وهي ال invasion
+
+264
+00:18:54,860 --> 00:19:00,340
+التي يتم من خلالها غوص ال embryo أو plasticist
+
+265
+00:19:00,340 --> 00:19:04,580
+بشكل شبه كامل داخل ال endometeria وتثبيتها بشكل
+
+266
+00:19:04,580 --> 00:19:09,540
+كبير جدا والبداية في تكوين البلسنتة
+
+267
+00:19:12,110 --> 00:19:17,450
+هذا بالنسبة إلى مراحل عملية الـ Implantation دعونا
+
+268
+00:19:17,450 --> 00:19:20,850
+ننتقل إلى موضوع جديد وهو الـ Embryo Transfer لم
+
+269
+00:19:20,850 --> 00:19:24,650
+أكن مسموح أن أعمل Embryo Transfer يعني 3 Embryo
+
+270
+00:19:24,650 --> 00:19:28,230
+بعد الحقن الميجاري ولا 2 ولا 4 ولا 5 في الغالب
+
+271
+00:19:28,230 --> 00:19:34,010
+معظم المراكز ثبتت إن أنا أعمل Transfer لتنوء 2
+
+272
+00:19:34,010 --> 00:19:37,370
+Embryo ولكن يعتمد هذا على الحالة ممكن أعمل
+
+273
+00:19:37,370 --> 00:19:42,150
+Transfer ل 1 Embryo أو 3 Embryo مع بعضفي الدول
+
+274
+00:19:42,150 --> 00:19:44,750
+البرا القانون واحد embryo مافيش اكتر و كده بعض
+
+275
+00:19:44,750 --> 00:19:49,370
+الحالات بيرجع اتنين بموافق خطية من المريض ولكن
+
+276
+00:19:49,370 --> 00:19:53,890
+قانونا one embryo embryo transfer can be performed
+
+277
+00:19:53,890 --> 00:19:57,990
+in the day three after cleavage or after
+
+278
+00:19:57,990 --> 00:20:03,130
+fertilization or day five in the plastocyst stage
+
+279
+00:20:03,130 --> 00:20:07,070
+after fertilization و هذا او after egg collection
+
+280
+00:20:07,070 --> 00:20:09,950
+and fertilizationيعني أنا مسموح ليه ك
+
+281
+00:20:09,950 --> 00:20:14,190
+emperiologist أرجع الأجنة في اليوم التاني أو اليوم
+
+282
+00:20:14,190 --> 00:20:18,910
+الخامس أو اليوم السادس طبعاً لها قوانين معينة لها
+
+283
+00:20:18,910 --> 00:20:22,150
+ضوابط معينة ولكن in general اليوم التالت بعض
+
+284
+00:20:22,150 --> 00:20:25,970
+الأحيان اليوم الخامسالـ United States على سبيل
+
+285
+00:20:25,970 --> 00:20:29,790
+المثال في protocol أنه أنا ما برجّع الجنين إلا في
+
+286
+00:20:29,790 --> 00:20:32,730
+اليوم الخامس يعني لما نصل لمرحلة ال plus و sixth
+
+287
+00:20:32,730 --> 00:20:38,250
+stage في اليوم التالت مسموح لأرجع فقط ال embryo
+
+288
+00:20:38,250 --> 00:20:41,910
+اللي هو عبارة عن good quality embryo or generally
+
+289
+00:20:41,910 --> 00:20:45,810
+between six to eight cells شو يعني good quality؟
+
+290
+00:20:45,810 --> 00:20:50,350
+هنعرفها كمان شوية ولكن بقول في اليوم التالت الجنين
+
+291
+00:20:50,350 --> 00:20:54,720
+دائما بكون من ست خلايا لتمان خلاياطالما الجنين وصل
+
+292
+00:20:54,720 --> 00:20:59,900
+ل 6 خلايا أو 8 خلايا مسموح لأرجع رجع جنين إلى رحم
+
+293
+00:20:59,900 --> 00:21:03,700
+السيدة أو اتنين أو تلاتة بناء على اعتبارات معينة
+
+294
+00:21:03,700 --> 00:21:08,830
+ولكن بعض المراكز ثبتت على اليوم الخامسالفرصة
+
+295
+00:21:08,830 --> 00:21:13,430
+للمنتظر حتى اليوم الخامس هي أنها تقدم وقت أضافي
+
+296
+00:21:13,430 --> 00:21:18,410
+لتختار البرنامج بقيمة أفضل لأن فقط 50%-60% من
+
+297
+00:21:18,410 --> 00:21:20,850
+البرنامج يمتلك القدرة على التطور إلى البرنامج
+
+298
+00:21:20,850 --> 00:21:25,450
+البلاستيكي ومن ثم أقل من البرنامج مستحيل للتبريد
+
+299
+00:21:25,450 --> 00:21:29,450
+والتحريك ليه سببته على اليوم الخامس؟ بقولك لأن
+
+300
+00:21:29,450 --> 00:21:32,830
+التأخر في عملية إرجاع الأجنب وبقاء الجنين في
+
+301
+00:21:32,830 --> 00:21:37,460
+المختبرفي الظروف المناسبة داخل ال incubator يسمح
+
+302
+00:21:37,460 --> 00:21:43,100
+للجنين بالنمو والتضاعف بشكل مناسب بشكل ملحوظ بشكل
+
+303
+00:21:43,100 --> 00:21:49,480
+يعطي له أفضلية للبقاء إن تم ترجعه أضيف إلى ذلك أن
+
+304
+00:21:49,480 --> 00:21:54,620
+تأخير عملية الترجع تعطيني information أكتر عن كيف
+
+305
+00:21:55,020 --> 00:21:58,520
+يتحرك هذا الجنين أو كيف ينمو هذا الجنين أو كيف
+
+306
+00:21:58,520 --> 00:22:03,840
+تنقسم خلايا هذا الجنين إضافة إلى أنها تسمح لي بعمل
+
+307
+00:22:03,840 --> 00:22:08,060
+فحوصات المطلوبة من أجل اختيار أفضل جنين من أجل
+
+308
+00:22:08,060 --> 00:22:13,100
+ارجع من أجل ارجع أيضا ان في بعض الأحيان بكون عندى
+
+309
+00:22:13,100 --> 00:22:18,310
+عشر أجنةفأنا بلجأ إلى تخزين بعض الأجنة مش منطق
+
+310
+00:22:18,310 --> 00:22:22,090
+أرجع عشر أجنة برجع تلاتة اتنين طب و الباقي أرميهم
+
+311
+00:22:22,090 --> 00:22:25,690
+أعملهم إتلاف أعملهم removing لأ بعمله بحاجة اسمها
+
+312
+00:22:25,690 --> 00:22:31,510
+freezing أو cryopreservation الحفظ بالتبريد طب أنا
+
+313
+00:22:31,510 --> 00:22:34,850
+مين أفضل أعمله cryopreservation و freezing و هو في
+
+314
+00:22:34,850 --> 00:22:39,270
+اليوم التاني أو التالت أو بعد خمس أيام كل ما زادت
+
+315
+00:22:39,270 --> 00:22:43,540
+فترة الانتظار كل ما كان نتيجة ال freezing أفضللأن
+
+316
+00:22:43,540 --> 00:22:48,380
+بكون الجنين كده خلايا شبه استقارات فبالتالي إذا
+
+317
+00:22:48,380 --> 00:22:51,140
+أنا عملت freezing في اليوم الخامس أو اليوم السادس
+
+318
+00:22:51,140 --> 00:22:54,440
+أفضل من إني أعمل freezing للأجنة أو للبواية ..
+
+319
+00:22:54,440 --> 00:22:58,460
+للأجنة عفوا في اليوم التاني أو التالت لأنه لسه ما
+
+320
+00:22:58,460 --> 00:23:03,960
+اتزالت في مرحلة الإنقاذ The recommended number of
+
+321
+00:23:03,960 --> 00:23:07,580
+embryo to transfer is determined by women age and
+
+322
+00:23:07,580 --> 00:23:10,930
+timing of the embryo transfer يعني أنا ..جدش بدأ
+
+323
+00:23:10,930 --> 00:23:13,790
+أرجع embryo هذا يعتمد على سن المرأة والله إذا كانت
+
+324
+00:23:13,790 --> 00:23:17,990
+المرأة كبيرة في العمر يعني بعد الأربعين فرصة
+
+325
+00:23:17,990 --> 00:23:22,090
+الإنجاب إلى كل ما زاد العمر تقل فبالتالي ممكن ألجأ
+
+326
+00:23:22,090 --> 00:23:27,110
+إلى زيادة عدد ال embryo المرجع السيدة لسه شابة في
+
+327
+00:23:27,110 --> 00:23:31,680
+بداية العشريناتمش منطقي أنا لسه عنده فترة زمانية
+
+328
+00:23:31,680 --> 00:23:34,060
+طويلة لإنجاب مرة و اتنين و تلاتة و أربع مش منطقي
+
+329
+00:23:34,060 --> 00:23:37,180
+في المرة الأولى أروح و أرجع لتلاتة embryo لأ واحد
+
+330
+00:23:37,180 --> 00:23:41,140
+اتنين maximum فبالتالي اللي بحكم هذه العملية عمر
+
+331
+00:23:41,140 --> 00:23:45,940
+السيدة و equality of embryo يعني أنه على سبيل
+
+332
+00:23:45,940 --> 00:23:50,460
+المثال عندي عشرة بويضات لقحت العشر بويضات أندي عشر
+
+333
+00:23:50,460 --> 00:23:54,360
+أجنة في العشر أجنة ما لجيت إلا اتنين embryo هم
+
+334
+00:23:54,360 --> 00:23:58,180
+اللي انقسموا و هم أفضل embryo اللي باجي مش كويسين
+
+335
+00:23:58,180 --> 00:24:03,350
+ده الفكرةمنطق أرجع للإثنين و أخلصنا من هذه القصة
+
+336
+00:24:03,350 --> 00:24:06,550
+لأنه ليس منطق أرجع واحد و بعدها أذهب و أعمله
+
+337
+00:24:06,550 --> 00:24:11,350
+freezing لأن تمانية الباقين ما انقسموا فبالتالي as
+
+338
+00:24:11,350 --> 00:24:16,270
+one chance أرجع الإثنين إحتياطا إثنين ناموا و
+
+339
+00:24:16,270 --> 00:24:19,010
+أصبحوا in block و أنا بيها واحد اه و واحد لأ كده
+
+340
+00:24:19,010 --> 00:24:24,350
+انا بكون عندي probability أو chance 50% a serum
+
+341
+00:24:24,350 --> 00:24:29,610
+pregnancy test is performed11 day after cleavage
+
+342
+00:24:29,610 --> 00:24:34,510
+or embryo transfer 9 day after blastocyst transfer
+
+343
+00:24:34,510 --> 00:24:40,950
+انا عملت نقل للاجنة ممكن اعمل فحص ال beta sc و او
+
+344
+00:24:40,950 --> 00:24:45,490
+فحص الحمل في اليوم رقم 11 من نقل ال embryo او في
+
+345
+00:24:45,490 --> 00:24:49,790
+اليوم رقم 9 من نقل ال blastocyst و معظمهم بيعملوا
+
+346
+00:24:49,790 --> 00:24:53,770
+في اليوم رقم 9 معظم في اليوم رقم 9 نادر جدا ما
+
+347
+00:24:53,770 --> 00:24:58,240
+يعملوا في اليوم رقم 14 معظم بيعملوا في اليومرقم 9
+
+348
+00:24:58,240 --> 00:25:01,580
+يعني بمعنى أخر في واحد الشهر صار embryo transfer
+
+349
+00:25:01,580 --> 00:25:05,940
+في عشر الشهر بتيجي بتعمل أو تسعة الشهر بتيجي بتعمل
+
+350
+00:25:05,940 --> 00:25:10,400
+ال beta at CG عشان تاخد احتياطاتها أيضا طبعا
+
+351
+00:25:10,400 --> 00:25:14,000
+بيعملوا من الدم مش من اليوريم خصوصا للسيدات اللي
+
+352
+00:25:14,000 --> 00:25:19,640
+خضعوا ال IV جدول بوضحلي عدد ال embryo المفضل
+
+353
+00:25:19,640 --> 00:25:24,940
+ارجعهابناء على العمر إذا كانت السيدة أقل من 35
+
+354
+00:25:24,940 --> 00:25:30,200
+برجع one embryo the best if no hcg embryo present
+
+355
+00:25:30,200 --> 00:25:33,620
+إذا مافيش إيش يعني hg high quality يعني إذا فيه
+
+356
+00:25:33,620 --> 00:25:36,220
+أنا عندي embryo high quality برجع واحد مافي عندي
+
+357
+00:25:36,220 --> 00:25:39,440
+high quality برجع اتنين هذه للسيدة اللي عمرها 35
+
+358
+00:25:39,440 --> 00:25:44,280
+وأقل من 35 ل 37 إذا في عندي high quality برجع واحد
+
+359
+00:25:44,280 --> 00:25:48,800
+مافيه برجع اتنين من 38 ل 40 مافي عندي high quality
+
+360
+00:25:48,800 --> 00:25:54,320
+هرجع اتنينhigh quality embryo ولكن عمرها 38 إذا
+
+361
+00:25:54,320 --> 00:25:59,120
+فرصة الإنجاب مستقبلا بتقلب ومابدأ أخضعها لل
+
+362
+00:25:59,120 --> 00:26:03,040
+ovarian stimulation أكتر من مرة فبرجع two embryo
+
+363
+00:26:03,040 --> 00:26:07,200
+علشان أزيد فرصة نجاح ال IVF والله مافي عندي high
+
+364
+00:26:07,200 --> 00:26:12,660
+quality embryo برجع تلاتة عندي عدد ال age أقل أربع
+
+365
+00:26:12,660 --> 00:26:15,780
+أربعين وفوق يعني أكبر من أربعين يعني قريبا من ال
+
+366
+00:26:15,780 --> 00:26:20,030
+monopiosبرجّه خمسة embryo رغم أنه موجود في high
+
+367
+00:26:20,030 --> 00:26:23,250
+quality embryo مافي عندي high quality أيضا برجّه
+
+368
+00:26:23,250 --> 00:26:27,230
+خمسة embryo شو يعني high quality؟ ال high quality
+
+369
+00:26:27,230 --> 00:26:33,350
+embryo يعني embryo يحتوي على ست خلايا بلاستوميرة
+
+370
+00:26:33,350 --> 00:26:38,490
+أو أكبر ست خلايا بلاستوميرة أو أكبر بمعنى أخر عدد
+
+371
+00:26:38,490 --> 00:26:44,530
+الأجنةالمرجعة تتناسب تناسبا ترضيا مع سن الزوجة أو
+
+372
+00:26:44,530 --> 00:26:52,010
+الأنفة كلما زاد سنها كلما زاد عدد الأجنة المرجعة
+
+373
+00:26:52,010 --> 00:26:59,310
+طبعا جدول آخر بوضّح لي شو يعني grade 1 و grade 2 و
+
+374
+00:26:59,310 --> 00:27:03,870
+grade 3 و grade 4 يعني شو يعني high quality embryo
+
+375
+00:27:03,870 --> 00:27:07,690
+grade 1 معناه الخلايا الـplastomeraالـ Plastomere
+
+376
+00:27:07,690 --> 00:27:11,610
+الموجودة داخل الـ embryo متساوية في الحجم و مافي
+
+377
+00:27:11,610 --> 00:27:15,970
+عنده fragmentation grade 2 متساوية في الحجم ولكن
+
+378
+00:27:15,970 --> 00:27:20,430
+في القليل من ال fragmentation grade 3 cell are
+
+379
+00:27:20,430 --> 00:27:24,990
+unequal in the size no fragmentation to moderate
+
+380
+00:27:24,990 --> 00:27:29,430
+fragmentation يعني مافي عنده تساوية في الحجم و
+
+381
+00:27:29,430 --> 00:27:35,190
+خلية عند مثلا في اليوم grade 3في اليوم التاني في
+
+382
+00:27:35,190 --> 00:27:37,150
+اليوم التاني المفروض يكون عندى أربعة خلايا لاجئت
+
+383
+00:27:37,150 --> 00:27:40,270
+تلت خلايا أكبر وخالية صغيرة مافي عندى تساوي في
+
+384
+00:27:40,270 --> 00:27:44,770
+الحجم فبسميها grade 3 وعندى ال fragmentation بدأ
+
+385
+00:27:44,770 --> 00:27:50,030
+يظهر moderate أما grade 4 هي عبارة عن ال cell are
+
+386
+00:27:50,030 --> 00:27:53,730
+of equal or unequal size fragmentation is moderate
+
+387
+00:27:53,730 --> 00:27:56,310
+to heavy في عندى fragmentation بشكل كبير جدا تاب
+
+388
+00:27:56,310 --> 00:28:01,570
+سؤالى متى بعمل evaluation أو grading لل embryo في
+
+389
+00:28:01,570 --> 00:28:04,710
+اليوم الأول من انقصاه؟يوم التاني وليوم التالت لأ
+
+390
+00:28:04,710 --> 00:28:09,710
+في يوم الترجيع بعمل عملية grading او evaluation او
+
+391
+00:28:09,710 --> 00:28:13,010
+ممكن ابدأ في اليوم التالت اليوم التالت اعمل
+
+392
+00:28:13,010 --> 00:28:16,510
+evaluation اليوم الرابع اليوم الخامس ويوم الترجيع
+
+393
+00:28:16,510 --> 00:28:19,550
+مهم جدا عشان اعرف والله هذا ال embryo رقم واحد
+
+394
+00:28:19,550 --> 00:28:23,410
+grade واحد رقم خمسة grade اتنين رقم عشرة grade
+
+395
+00:28:23,410 --> 00:28:27,790
+واحد فبرجع فقط ل grade واحد بين جثين high quality
+
+396
+00:28:27,790 --> 00:28:32,090
+يعني grade واحد معناها high quality وتتميز بوجود
+
+397
+00:28:33,010 --> 00:28:37,750
+تناسق وتساوي في حجم الخلايا الموجودة داخل الـ
+
+398
+00:28:37,750 --> 00:28:40,810
+Imperolizameta Plastomera بالاضافة إلى عدم وجود
+
+399
+00:28:40,810 --> 00:28:45,770
+fragment في الـCytoplasm كيف يتم عملية الإرجاع؟
+
+400
+00:28:45,770 --> 00:28:50,070
+صورة بتوضح معظم ال steps اللي احنا اتكلمنا عنها في
+
+401
+00:28:50,070 --> 00:28:53,940
+عملية الإجزينبدأ بالخطوة الأولى وهي عبارة عن
+
+402
+00:28:53,940 --> 00:28:57,340
+ovarian stimulation زوجة بتخضع إلى ال agonist أو
+
+403
+00:28:57,340 --> 00:29:00,520
+ال antagonist ovarian stimulation protocol سواء
+
+404
+00:29:00,520 --> 00:29:06,700
+كانت short أو long أو ultra short short long ultra
+
+405
+00:29:06,700 --> 00:29:14,620
+short protocol بعد كده المبيضة ببدأ البويضات
+
+406
+00:29:14,620 --> 00:29:17,520
+الفولك اللي بتنمو البويضات تنضج بصير عندي
+
+407
+00:29:17,520 --> 00:29:21,960
+aspiration for egg و اللي سميتها egg backupبعد كده
+
+408
+00:29:21,960 --> 00:29:25,060
+ال egg pick up بيسيلها عملية treatment عن طريق ال
+
+409
+00:29:25,060 --> 00:29:29,780
+denodation و خلافه في نفس اللحظة باجي بعمل semen
+
+410
+00:29:29,780 --> 00:29:36,360
+analysis للميل و semen preparation بعد كده بعمل
+
+411
+00:29:36,360 --> 00:29:40,140
+fertilization إما باستخدام ال IVF إنه بوايضة مع ال
+
+412
+00:29:40,140 --> 00:29:43,460
+sperm أو باستخدام ال eggs on درجة الحقن المجهري
+
+413
+00:29:43,460 --> 00:29:47,860
+بعد عملية ال fertilization تبدأ البوايضة بالانقسام
+
+414
+00:29:47,860 --> 00:29:55,160
+زي goatخليتين، أربع خلايا، ثم تمن خلايا وست وستاش
+
+415
+00:29:55,160 --> 00:29:59,220
+واتنين وتلاتين بعد كده لما تصل لمرحلة الـ Morella
+
+416
+00:29:59,220 --> 00:30:05,280
+أو الـ Plasticist باجي بعملية الإرجاع من خلال
+
+417
+00:30:05,280 --> 00:30:09,280
+مرحلة بنسميها Embryo Transfer وعملية الإرجاع لا
+
+418
+00:30:09,280 --> 00:30:13,940
+تحدث إلا للأجنة لأنها تعتبر grade one كfirst
+
+419
+00:30:13,940 --> 00:30:14,440
+chance
+
+420
+00:30:21,550 --> 00:30:24,790
+الأخير الموضوع اللي بنتكلم فيه هو الـ
+
+421
+00:30:24,790 --> 00:30:31,730
+cryopreservation كيف نقوم لعملية حفظ
+
+422
+00:30:31,730 --> 00:30:38,030
+البويضة أو حفظ الأجنة عندى خمس أجنة عمر
+
+423
+00:30:38,030 --> 00:30:40,950
+السيدة أقل من تلاتين سنة يعني لازم بناء على
+
+424
+00:30:40,950 --> 00:30:45,920
+القانون أرجع جنين واحد للباقى الأجنة أعملهمبعملهم
+
+425
+00:30:45,920 --> 00:30:49,760
+Cryopreservation شو يعني Cryopreservation؟ كيف
+
+426
+00:30:49,760 --> 00:30:54,600
+نقوم بعمل Cryopreservation؟ فعملية التقنيات
+
+427
+00:30:54,600 --> 00:30:59,920
+المساعدة على الإنجاب تعتبر أفضل التقنية .. تقنية
+
+428
+00:30:59,920 --> 00:31:03,120
+الـ Exit طبعا في الوضع الحالي أفضل التقنيات التي
+
+429
+00:31:03,120 --> 00:31:07,540
+تستخدم لحل مشكلة ال infertility عند الفيميل
+
+430
+00:31:07,540 --> 00:31:12,060
+بالإضافة إلى عملية حفظ ال fertility للمال والفيميل
+
+431
+00:31:12,060 --> 00:31:15,710
+كيف يعني حفظ ال fertility؟ يعنيفي ميل بدأت أتعرض
+
+432
+00:31:15,710 --> 00:31:20,130
+لراديو ثيرابي كيمو ثيرابي باجي بخليها تخضع ل
+
+433
+00:31:20,130 --> 00:31:24,690
+ovarian stimulation بجمع البويضات والبويضات بعملها
+
+434
+00:31:24,690 --> 00:31:32,330
+cryopreservation حفظ أو عندي ميل بده يعمل إجزي هو
+
+435
+00:31:32,330 --> 00:31:35,690
+و ال cabulist بتاعه بده يعمل إجزي مش مابقدر يجيب
+
+436
+00:31:35,690 --> 00:31:38,550
+عينة دائما مش دائما ال parameter بتاعة ال semen
+
+437
+00:31:38,550 --> 00:31:42,530
+fluid بتكون طبيعية فمرة من المرات جاب عينة لجناها
+
+438
+00:31:42,770 --> 00:31:46,530
+Full Normal خلّيني أسميها بهذا الشكل أو Normal
+
+439
+00:31:46,530 --> 00:31:50,290
+بالنسبة لـ 50% فبلجأ إنه أحفظ الـ spermatozoa عن
+
+440
+00:31:50,290 --> 00:31:54,830
+طريق الـ Cryopreservation حتى تتم عملية الـ XGB
+
+441
+00:31:54,830 --> 00:31:58,510
+نجح أول حاجة جاميط الـ Cryopreservation لما أقول
+
+442
+00:31:58,510 --> 00:32:01,590
+جاميط الـ Cryopreservation يعني عملية تخزين
+
+443
+00:32:01,590 --> 00:32:05,150
+الجاميطات الأنثوية متمثلة في البويضات أو الجاميطات
+
+444
+00:32:05,150 --> 00:32:08,870
+الذكرية متمثلة في الـ sperm ممكن أن أحفظهم ممكن
+
+445
+00:32:08,870 --> 00:32:14,130
+أحفظهم ممكن يكونواavailable ممكن يعطوا نتيجة في
+
+446
+00:32:14,130 --> 00:32:17,790
+مباعد صحيح ممكن يكونوا available ويعطوا نتيجة اذا
+
+447
+00:32:17,790 --> 00:32:22,650
+عملية الجامد crab reservation تعتبر عملية مهمة جدا
+
+448
+00:32:22,650 --> 00:32:27,870
+للحفاظ على ال fertility for male and female before
+
+449
+00:32:27,870 --> 00:32:31,910
+exposure and this is process of care before
+
+450
+00:32:31,910 --> 00:32:35,250
+exposure to the cytotoxic therapy or chemotherapy
+
+451
+00:32:36,060 --> 00:32:38,940
+ممكن أعمل جميط ممكن أعمل جميط cryopreservation
+
+452
+00:32:38,940 --> 00:32:42,600
+ممكن أعمل embryo ممكن أعمل embryo cryopreservation
+
+453
+00:32:42,600 --> 00:32:47,720
+طبعا هذه بتعطي قابلية للإنجاب في مبعد للمال
+
+454
+00:32:47,720 --> 00:32:52,880
+والفيميل The ability of Iglis Harol to act as a
+
+455
+00:32:52,880 --> 00:32:56,260
+cryoprotective agent during freezing and thawing
+
+456
+00:32:56,260 --> 00:33:01,420
+of spermatozoa was the fairest report in 190094
+
+457
+00:33:01,420 --> 00:33:05,520
+طبعاً أول ما تم استخدام الـ cryoprotective agent
+
+458
+00:33:05,520 --> 00:33:10,140
+التي تحمي الجميطات من عملية التكسر و الانهيار
+
+459
+00:33:10,140 --> 00:33:14,260
+استخدمه لـ glycerol كان هو أول cryoprotective
+
+460
+00:33:14,260 --> 00:33:20,160
+agent و تم استخدامه في عام 1949 و فيما بعد كان أول
+
+461
+00:33:20,160 --> 00:33:25,940
+طفل نتج من عملية جميط cryopreservation تم تسجيلها
+
+462
+00:33:25,940 --> 00:33:31,740
+في عام 1950وهو عبارة عن طفل أنجب بعد ما تم تلقيح
+
+463
+00:33:31,740 --> 00:33:35,820
+البوادة من cryopreservative او cryopreserved sperm
+
+464
+00:33:35,820 --> 00:33:43,400
+تم تخزينه استخدام ال cryopreservation survival
+
+465
+00:33:43,400 --> 00:33:46,820
+fertilization and fetal development followed
+
+466
+00:33:46,820 --> 00:33:50,340
+cryopreservation of unfertilized mouse or oocyte
+
+467
+00:33:50,340 --> 00:33:56,180
+using dimso were the first report in 1917 يعني
+
+468
+00:33:56,180 --> 00:34:00,850
+بمعنى أخربعد كده تم تطوير بعض الـ cryoprotective
+
+469
+00:34:00,850 --> 00:34:05,170
+agent بخلاف الجليسرول فاستخدموا الدمسو و الدمسو هي
+
+470
+00:34:05,170 --> 00:34:10,610
+عبارة عن مادة كيميائية إلى حد ما تستخدم as
+
+471
+00:34:10,610 --> 00:34:15,050
+cryopreservative agent زيها زي الجليسرول و تم
+
+472
+00:34:15,050 --> 00:34:19,630
+اعطاء نتائج جدا رائعة في عملية الـ
+
+473
+00:34:19,630 --> 00:34:22,590
+cryopreservation و الحفاظ على الجميطات من عملية
+
+474
+00:34:22,590 --> 00:34:26,350
+الانهيار والتكسفطيب سؤالي when the oocyte
+
+475
+00:34:26,350 --> 00:34:29,410
+fertilizing .. fertilizing كان okay متى انا ممكن
+
+476
+00:34:29,410 --> 00:34:35,290
+اعمل fertili .. متى ممكن اعمل ال freezing لل
+
+477
+00:34:35,290 --> 00:34:39,830
+oocyte تحت عنوان when the oocyte freezing كان okay
+
+478
+00:34:39,830 --> 00:34:45,090
+متى ممكن اعمل freezing لل oocyte طبعا في عندي اكثر
+
+479
+00:34:45,090 --> 00:34:49,250
+من حالة ممكن اعملها freezing طبعا women محتاجة
+
+480
+00:34:49,250 --> 00:34:52,090
+انها تعمل .. تاخد جرعة chemotherapy او
+
+481
+00:34:52,090 --> 00:34:56,040
+radiotherapyولكن عندها رغبة في الإنجاب فيما بعد
+
+482
+00:34:56,040 --> 00:34:59,940
+لأن سنها ما زال صغير تلاتين سنة مثلا أو أواخر
+
+483
+00:34:59,940 --> 00:35:03,580
+الأشرينات ولكن شقة الأقدار انها صار عندها cancer
+
+484
+00:35:03,580 --> 00:35:07,320
+راحت تعمل ريديو ثيرابي كيميو ثيرابي شرعات فبدها
+
+485
+00:35:07,320 --> 00:35:11,500
+تنجب فيما بعد فممكن نعملها oocyte freezing من خلال
+
+486
+00:35:11,500 --> 00:35:15,540
+إدخالها في برنامج ovarian stimulation وجمع أكبر
+
+487
+00:35:15,540 --> 00:35:19,840
+عدد من البويضات وتخزينها وبعد فترة زمنية من انتهاء
+
+488
+00:35:19,840 --> 00:35:23,460
+الحالة الموجودة حالياأو انتهاء جرعة الكيموثيرابي
+
+489
+00:35:23,460 --> 00:35:28,220
+ممكن تبدأ بعملية الـcycling الجديدة اللي لها من
+
+490
+00:35:28,220 --> 00:35:32,760
+خلال عملية الـthawing for oocyte freezing بعدين ال
+
+491
+00:35:32,760 --> 00:35:37,420
+fertilization بعض ال medication زي حكينا ال radio
+
+492
+00:35:37,420 --> 00:35:40,440
+therapy و الكيموثيرابي اللي ممكن تدمر ال fertility
+
+493
+00:35:40,440 --> 00:35:43,820
+الخاصة بالفيميل ال IgG freezing before treatment
+
+494
+00:35:43,820 --> 00:35:47,560
+maybe enable you to have biological children later
+
+495
+00:35:47,560 --> 00:35:51,900
+أكيدwomen undergoing in vitro fertilization when
+
+496
+00:35:51,900 --> 00:35:56,180
+undergoing in vitro fertilization some people
+
+497
+00:35:56,180 --> 00:35:59,000
+preferred egg fertilization to embryo freezing for
+
+498
+00:35:59,000 --> 00:36:03,980
+ethical reasons women wish to preserve young egg
+
+499
+00:36:03,980 --> 00:36:07,620
+now for future use يعني في أكتر من حالة من حالات
+
+500
+00:36:07,620 --> 00:36:11,640
+اللي حاليا صارت المشكلة تظهر على الصدح بكميات
+
+501
+00:36:11,640 --> 00:36:16,810
+كبيرة جدا و في مجتمعاتنا العربيةخصوصا في الناس
+
+502
+00:36:16,810 --> 00:36:20,270
+اللي بتشتغل as fashionist على سبيل المثال بتقوم
+
+503
+00:36:20,270 --> 00:36:26,430
+بتخزين بوايضاتها الشابة علشان مايصير عملية إنجاب
+
+504
+00:36:26,430 --> 00:36:30,570
+وعملية حمل خلال فترة عملها على سبيل المثال و بعد
+
+505
+00:36:30,570 --> 00:36:34,210
+فترة زمانية عشر سنين عشرين سنة whatever يعني ال
+
+506
+00:36:34,210 --> 00:36:38,410
+calendar الخاصة فيها وقت ما بدها تنجب تروح تستخدم
+
+507
+00:36:38,410 --> 00:36:41,590
+البوايضات المخزنة زي ما في عندنا sperm banking في
+
+508
+00:36:41,590 --> 00:36:45,070
+عندنا oocyte banking صار حالياحتى الـ oxide
+
+509
+00:36:45,070 --> 00:36:48,130
+banking ممكن تؤجر ممكن تباع زي الـ spare banking
+
+510
+00:36:48,130 --> 00:36:52,190
+ممكن تباع مافي مشكلة بس طبعا هذا مش في مجتمعاتنا
+
+511
+00:36:52,190 --> 00:36:56,150
+موجودة في المجتمعات الغربية ولكن في مجتمعاتنا بدأت
+
+512
+00:36:56,150 --> 00:37:00,310
+تظهر ظاهرة جديدة وهي الظاهرة الموجودة في آخر ال
+
+513
+00:37:00,310 --> 00:37:04,310
+slide التي بعنوان women wish to preserve younger
+
+514
+00:37:04,310 --> 00:37:12,180
+egg now for if youth are used طبعاخلال عملية الـ
+
+515
+00:37:12,180 --> 00:37:15,300
+Cryopreservation أو الـ freezing للـ Oocyte الـ
+
+516
+00:37:15,300 --> 00:37:18,680
+Oocyte ما بتتمهد العملية بشكل سلس بشكل سهل الـ
+
+517
+00:37:18,680 --> 00:37:22,900
+Oocyte بتتعرض لعديد من الـ challenging لعديد من
+
+518
+00:37:22,900 --> 00:37:26,480
+المخاطر قد تؤدي إلى حدوث rupture في الـ Oocyte
+
+519
+00:37:26,480 --> 00:37:32,660
+وفقدان الـ Oocyte بفعل تكوين crystal ice داخل الـ
+
+520
+00:37:32,660 --> 00:37:36,640
+cytoplasm الخاص بالـ Oocyte مما يؤدي إلى تمزيق
+
+521
+00:37:36,640 --> 00:37:40,410
+الغشاء الخلوي الخاص بالـ Oocyte white layerهذه
+
+522
+00:37:40,410 --> 00:37:45,850
+أشهر المعوقات التي تتواجه
+
+523
+00:37:45,850 --> 00:37:48,950
+الـ oocyte خلال عملية الـ freezing أو الـ
+
+524
+00:37:48,950 --> 00:37:51,390
+cryopreservation ممكن أن أتجنب تكوين ال ice
+
+525
+00:37:51,390 --> 00:37:56,070
+crystal and toxic concentration of salt which are
+
+526
+00:37:56,070 --> 00:37:59,130
+the two main cause of the cell death associated
+
+527
+00:37:59,130 --> 00:38:02,110
+with cryopreservation while maintaining the
+
+528
+00:38:02,110 --> 00:38:05,010
+functional of intracellular organelle and the
+
+529
+00:38:05,010 --> 00:38:10,070
+viability of the embryo oocyteيعني أشهر نقطتين
+
+530
+00:38:10,070 --> 00:38:14,270
+تتعرض إليه أو خطريًا تتعرض إليهم الـ oocyte خلال
+
+531
+00:38:14,270 --> 00:38:18,470
+عملية الـ cryopreservation أو الـ freezing تكوين
+
+532
+00:38:18,470 --> 00:38:23,850
+ال ice crystal و ال toxicity الخاصة بالمواد التي
+
+533
+00:38:23,850 --> 00:38:29,170
+تستخدم ولكن حاليًا أصبح هناك إمكانية أن أمنع خطر
+
+534
+00:38:29,170 --> 00:38:32,890
+النقطتين هدولة من خلال استخدام ما يعرف باسم الـ
+
+535
+00:38:32,890 --> 00:38:38,140
+cryoprotective additive or cryoprotective agentإذن
+
+536
+00:38:38,140 --> 00:38:42,100
+هناك خطرين تواجهها البويضة خلال عملية التخزين
+
+537
+00:38:42,100 --> 00:38:47,000
+تكوين ال ice crystal خطر و ال toxicity الخاصة
+
+538
+00:38:47,000 --> 00:38:51,080
+بالمواد المستخدمة ممكن أنا أتجنب هذا الخطرين من
+
+539
+00:38:51,080 --> 00:38:55,140
+خلال استخدام شيء بسميه CPA و هي cryoprotective
+
+540
+00:38:55,140 --> 00:38:59,060
+agentمن أشهر الـ cryoprotective agent هنتكلم عنها
+
+541
+00:38:59,060 --> 00:39:02,880
+كمان شوية exposure to cryoprotective agent support
+
+542
+00:39:02,880 --> 00:39:05,640
+the dehydration of the cell and reduce
+
+543
+00:39:05,640 --> 00:39:08,920
+intracellular ice formation إذن ال cryoprotective
+
+544
+00:39:08,920 --> 00:39:13,200
+agent بعمل dehydration للخلية فبالتالي بنزع منها
+
+545
+00:39:13,200 --> 00:39:16,780
+الماء فبالتالي ما بتتكون ال ice crystal داخل
+
+546
+00:39:16,780 --> 00:39:21,230
+الخليةمن أشهر الـ CBA على سبيل المثال، هنتقسم إلى
+
+547
+00:39:21,230 --> 00:39:24,270
+قسمين القسم الأول بيسميه Intracellular والقسم
+
+548
+00:39:24,270 --> 00:39:27,730
+التاني بيسميه Extracellular الـ Intracellular
+
+549
+00:39:27,730 --> 00:39:33,330
+membrane permitting زي Glucerol، Dimethylglucerol
+
+550
+00:39:33,330 --> 00:39:40,390
+والإيثيلينيجليسرول إذا عندي الجليكول،
+
+551
+00:39:40,390 --> 00:39:44,230
+Dimethylglucerol، إيثيلينيجليكول أربع أنواع من
+
+552
+00:39:44,230 --> 00:39:49,520
+أنواع الـ Intracellular membrane permittingأما الـ
+
+553
+00:39:49,520 --> 00:39:53,500
+Extracellular Membrane Non-permenting زي السكاروز
+
+554
+00:39:53,500 --> 00:39:58,040
+والجليكوز والأميند والبروتينز والليبوبروتينز إذا
+
+555
+00:39:58,040 --> 00:40:01,420
+في عندي نوعين منهم واحد Intracellular وواحد
+
+556
+00:40:01,420 --> 00:40:08,760
+Extracellular طبعا الـ Pre-Nipple-CPA Removing
+
+557
+00:40:08,760 --> 00:40:14,300
+Water بشتغل على إزالة الـ Intracellular بشتغل على
+
+558
+00:40:14,300 --> 00:40:19,380
+إزالة الماء من داخل الـ Oocyteمن خلال الإزالة
+
+559
+00:40:19,380 --> 00:40:23,360
+التدريجية Why? An osmotic gradient and partially
+
+560
+00:40:23,360 --> 00:40:26,580
+occupy the place of intracellular water while the
+
+561
+00:40:26,580 --> 00:40:29,880
+extracellular في المقابل Extracellular increase
+
+562
+00:40:29,880 --> 00:40:34,580
+the extracellular osmolarity generating an osmotic
+
+563
+00:40:34,580 --> 00:40:37,420
+gradient across the cell membrane supporting the
+
+564
+00:40:37,420 --> 00:40:39,800
+dehydration of the cell before CP
+
+565
+00:40:42,590 --> 00:40:46,190
+إذن في هندي طريقتين للعمل الطريقة الـ
+
+566
+00:40:46,190 --> 00:40:49,210
+intracellular إنه بعمل removing للماء الموجود داخل
+
+567
+00:40:49,210 --> 00:40:53,430
+الخلية من خلال الـ osmotic gradient و بحتل مكان
+
+568
+00:40:53,430 --> 00:40:56,750
+الماء بشكل تدريجي في المقابل الـ extracellular
+
+569
+00:40:56,750 --> 00:41:01,510
+بعمل زيادة للـ extracellular osmolarity مما يؤدي
+
+570
+00:41:01,510 --> 00:41:06,090
+إلى إخراج الماء بشكل كاملوعمل ال dehydration ولكن
+
+571
+00:41:06,090 --> 00:41:10,570
+تحدث قبل ال CB والمقصود بال CB في هذه الفقرة مقصود
+
+572
+00:41:10,570 --> 00:41:15,490
+بال CB هي ال cryopreservation at the same time it
+
+573
+00:41:15,490 --> 00:41:18,050
+prevents the rapidly enter of the water into the
+
+574
+00:41:18,050 --> 00:41:21,170
+cell after thawing during rehydration of the
+
+575
+00:41:21,170 --> 00:41:26,410
+permitting CBA طيب اي بوادة صارلة freezing او
+
+576
+00:41:26,410 --> 00:41:29,250
+صارلة cryopreservation لما بدي استخدمها لازم
+
+577
+00:41:29,250 --> 00:41:34,130
+اعملها thawing شو يعني thawing يعني اذابةبدي
+
+578
+00:41:34,130 --> 00:41:39,350
+أعملها إذابة و أرجعها ضيبل فالـ intracellular في
+
+579
+00:41:39,350 --> 00:41:43,990
+نفس اللحظة أنه هو بيحافظ على ال oocyte خلال عملية
+
+580
+00:41:43,990 --> 00:41:47,590
+ال cryopreservation أيضا بيحافظ على ال oocyte خلال
+
+581
+00:41:47,590 --> 00:41:52,410
+عملية thawing من خلال شو؟ من خلال منع ما يسمى
+
+582
+00:41:52,410 --> 00:41:56,290
+rabbit enter of water into the cell after thawing
+
+583
+00:41:56,290 --> 00:42:00,270
+يعني بيمنع دخول الماء أو بيمنع دخول الماء السريع
+
+584
+00:42:00,270 --> 00:42:06,390
+داخل ال oocyte خلال عمليةالاذابة أو عملية الاذابة
+
+585
+00:42:06,390 --> 00:42:10,170
+أو عملية الـrehydration مما يحافظ على البويضة في
+
+586
+00:42:10,170 --> 00:42:15,790
+أفضل صورة ممكنة لها إذن الـIntracellular ما بحمل
+
+587
+00:42:15,790 --> 00:42:20,430
+بويضة خلال عملية التجميد فقط لأ بحميها خلال عملية
+
+588
+00:42:20,430 --> 00:42:24,530
+الـrehydration من خلال إيقاف عملية تدفق الماء
+
+589
+00:42:24,530 --> 00:42:29,550
+السريع داخل البويضة خلال أو بعد عملية الـthaw
+
+590
+00:42:31,020 --> 00:42:33,200
+Dehydration of the cell mainly depending on the
+
+591
+00:42:33,200 --> 00:42:36,680
+permeability properties of the cell membraneدخول
+
+592
+00:42:36,680 --> 00:42:39,120
+الماء وخروج الماء و بالذات أنا بحكي هنا على الـ
+
+593
+00:42:39,120 --> 00:42:41,420
+dehydration خروج الماء خلال عملية الـ
+
+594
+00:42:41,420 --> 00:42:45,360
+cryopreservation يعتمد بشكل أساسي على ال
+
+595
+00:42:45,360 --> 00:42:47,360
+permeability of the cell membrane إذا كانت ال cell
+
+596
+00:42:47,360 --> 00:42:50,660
+membrane permeability جيدة إذا العملية استقول
+
+597
+00:42:50,660 --> 00:42:54,440
+وتنتهي بنجاح ال permeability properties of the
+
+598
+00:42:54,440 --> 00:42:58,160
+immature and mature oocyte different and can be
+
+599
+00:42:58,160 --> 00:43:02,320
+there by seven fold between individual human of
+
+600
+00:43:03,160 --> 00:43:07,600
+Oocite in the Metaphase-II أكيد طالما أنا عندي
+
+601
+00:43:07,600 --> 00:43:11,140
+Oocite هذا الـ Oocite لما تكون mature ال
+
+602
+00:43:11,140 --> 00:43:15,320
+permeability تختلف عنما تكون immature فبالتالي في
+
+603
+00:43:15,320 --> 00:43:19,940
+اختلاف هذا الاختلاف يقدر بسبع مرات مختلف أو سبع
+
+604
+00:43:19,940 --> 00:43:24,320
+أضعاف الاختلاف بين permeability of mature Oocite
+
+605
+00:43:24,320 --> 00:43:27,930
+and immature Oociteهذا الاختلاف في الـ
+
+606
+00:43:27,930 --> 00:43:31,730
+permeability البرميابيات قد تتأثر قوة قوة على
+
+607
+00:43:31,730 --> 00:43:35,170
+نتيجة الانتقال اللازمة من الـ oocyte لكنها يمكن أن
+
+608
+00:43:35,170 --> 00:43:39,290
+تكون تحكم بإنعكاس مقاومة الـ non-permeability الـ
+
+609
+00:43:39,290 --> 00:43:44,090
+CpA ومقاومة البيئة طالما أن في عندي permeability
+
+610
+00:43:44,090 --> 00:43:46,510
+مختلفة ما بين ال mature oocyte و ال immature
+
+611
+00:43:46,510 --> 00:43:51,430
+oocyte هذا الاختلاف وجدوا أنه بلعب دور كبير جدا في
+
+612
+00:43:51,910 --> 00:43:59,590
+الـ outcome of cell freezing يعني نجاح
+
+613
+00:43:59,590 --> 00:44:02,830
+الـ oocyte freezing باستخدام ال slow method هل
+
+614
+00:44:02,830 --> 00:44:07,360
+تنجح أم لا تنجح؟ولكن في المقابل وجدوا أن هناك
+
+615
+00:44:07,360 --> 00:44:11,920
+قابلية للتحكم في هذا الأمر من خلال زيادة مستوى للـ
+
+616
+00:44:11,920 --> 00:44:14,760
+cryoprotective agent اللي بيستخدموه و خاصة إن إذا
+
+617
+00:44:14,760 --> 00:44:18,280
+كان intracellular و خاصة إن إذا كان عفوا non
+
+618
+00:44:18,280 --> 00:44:21,300
+permeable وهو الـ extracellular بالإضافة إلى
+
+619
+00:44:21,300 --> 00:44:25,040
+التحكم في كمية الحرارة ال environment temperature
+
+620
+00:44:25,040 --> 00:44:28,940
+الموجودة إذا مافي حاجة اسمها خطأ مطلق مافي حاجة
+
+621
+00:44:28,940 --> 00:44:33,510
+اسمها عامل يؤثر بشكل مطلقلأ في عندي إمكانية للتحكم
+
+622
+00:44:33,510 --> 00:44:38,070
+في هذه الأمور By having the concentration of non
+
+623
+00:44:38,070 --> 00:44:44,530
+-permitting cryoprotective agent increase عن طريق
+
+624
+00:44:44,530 --> 00:44:51,350
+زيادة ال-CPA كتركيزه فممكن أستخدم سكروز 0.2 أو 0.3
+
+625
+00:44:51,350 --> 00:44:55,170
+مولار وخدوا بالك أنا قلت non-permitting يعني عبارة
+
+626
+00:44:55,170 --> 00:45:01,200
+عنبناء على هذه الصورة الـ Extracellular
+
+627
+00:45:01,200 --> 00:45:06,760
+فممكن أزيدها لتصل تركيز السكاروز as CpA إلى 0.2 أو
+
+628
+00:45:06,760 --> 00:45:12,140
+0.3 مولار هذا بعمل زيادة في survivor rate لل
+
+629
+00:45:12,140 --> 00:45:16,720
+oocyte خلال عملية freezing over all freezing
+
+630
+00:45:16,720 --> 00:45:20,020
+fertilization rate of freezing thawing oocyte
+
+631
+00:45:20,020 --> 00:45:25,180
+appeared to be similar to those of fresh oocyteعن
+
+632
+00:45:25,180 --> 00:45:30,320
+زيادة الـ CBA concentration علشان يصل إلى 0.2 أو 0
+
+633
+00:45:30,320 --> 00:45:35,420
+.3 مولار بيخلّي ال survival rate عالي جدا بيخلّي
+
+634
+00:45:35,420 --> 00:45:39,940
+ال fertilization rate للبوايضة المقصبة التي نتجت
+
+635
+00:45:39,940 --> 00:45:43,300
+بعد عملية ال throwing تشبه ال fertilization rate
+
+636
+00:45:43,300 --> 00:45:47,280
+للبوايضة ال fresh يعني مافي عندى اختلاف؟ اه مافي
+
+637
+00:45:47,280 --> 00:45:51,000
+عندى اختلاف بناهن طبعا هذا مش اراه بناهن على أبحاث
+
+638
+00:45:51,000 --> 00:45:55,980
+و دراسات أجريا على بوايضاتخُصّبت بعد أن حدث لها
+
+639
+00:45:55,980 --> 00:45:58,900
+عملية thawing وهي تعرضت لـ cryopreservation
+
+640
+00:45:58,900 --> 00:46:02,940
+باستخدام الـCPA الـexternal extracellular بتركيز 0
+
+641
+00:46:02,940 --> 00:46:09,340
+.2 و 0.3 مولار طبعا قبل الـslow cooling
+
+642
+00:46:09,340 --> 00:46:12,420
+dehydration of the embryo site is carried out by
+
+643
+00:46:12,420 --> 00:46:16,830
+exposure to a mixture ofPermeable and non
+
+644
+00:46:16,830 --> 00:46:20,570
+-permeable CBA duration 10 minutes يعني ممكن انا
+
+645
+00:46:20,570 --> 00:46:26,990
+ازيد كمان ال survivor rate لل Oocyte و امنع ال bad
+
+646
+00:46:26,990 --> 00:46:32,790
+effect ل ال CBA من خلال عمل mixing أو تعريض ال
+
+647
+00:46:32,790 --> 00:46:36,490
+Oocyte لخليط من ال intracellular و ال
+
+648
+00:46:36,490 --> 00:46:41,870
+extracellular CBA لمدة عشرة minutes Currently
+
+649
+00:46:41,870 --> 00:46:46,820
+there are two methodsحالياً في عندى طريقتين لعملية
+
+650
+00:46:46,820 --> 00:46:49,740
+ال freezing طريقة بتسميها slow rate freezing و هي
+
+651
+00:46:49,740 --> 00:46:53,240
+طريقة بضيئة جدا بتاخد تلت ساعات او سعتين بناء على
+
+652
+00:46:53,240 --> 00:46:56,240
+ال machine المستخدمة و طريقة بتسميها طريقة سريعة
+
+653
+00:46:56,240 --> 00:46:59,580
+بتسميها ال vitrification اذا في عندنا ال oocyte و
+
+654
+00:46:59,580 --> 00:47:02,560
+ال embryo طريقتين لعملية ال freezing طريقة ال slow
+
+655
+00:47:02,560 --> 00:47:07,720
+rate freezing و هى تعتمد على machine و طريقة اسمها
+
+656
+00:47:07,720 --> 00:47:09,300
+very fast او verification
+
+657
+00:47:13,020 --> 00:47:16,700
+طبعاً في مختبرات بتستخدم الطريقة الأولى وطريقة
+
+658
+00:47:16,700 --> 00:47:20,280
+ناجحة وفي مختبرات بسبب الضغط اللي عمل عليها
+
+659
+00:47:20,280 --> 00:47:23,400
+بتستخدم طريقة ال vitrification طريقة ناجحة بشكل
+
+660
+00:47:23,400 --> 00:47:27,840
+كبير جدا تاخدش تقريبا دقيقة واحدة during rib
+
+661
+00:47:27,840 --> 00:47:32,540
+reservation cell are exposed to a number of stress
+
+662
+00:47:32,540 --> 00:47:35,940
+factors mechanical, thermal, chemical which can
+
+663
+00:47:35,940 --> 00:47:39,620
+lead to defect the cell functional and lead to
+
+664
+00:47:39,620 --> 00:47:42,350
+cell deathيعني خلال عملية الـ Crime Preservation
+
+665
+00:47:42,350 --> 00:47:47,070
+الخلية ما بتكون منعمة ما بتكون في بيئة optimal
+
+666
+00:47:47,070 --> 00:47:51,890
+condition لأ بتتعرض إلى بعض العوامل الضغطة سواء
+
+667
+00:47:51,890 --> 00:47:55,070
+كانت عوامل كيميائية أو بيئية أو حرارية أو
+
+668
+00:47:55,070 --> 00:47:59,010
+ميكانيكية وانت بتشتغل وانت بتضغط عليها باستخدام ال
+
+669
+00:47:59,010 --> 00:48:03,830
+needle هذه كلها عوامل ممكن تؤدي إلى قتل الخلية أو
+
+670
+00:48:03,830 --> 00:48:08,490
+تؤدي إلى إيقاف وظيفتها إلى إيقاف وظيفتها بشكل عام
+
+671
+00:48:10,790 --> 00:48:13,630
+It has been demonstrated that oocyte are more
+
+672
+00:48:13,630 --> 00:48:17,470
+sensitive to cryodamage than later embryonic stage
+
+673
+00:48:17,470 --> 00:48:23,050
+بشكل عام حكوا ووجدوا أن البويضة إذا تعرضت لـ
+
+674
+00:48:23,050 --> 00:48:26,230
+Cryopreservation هيكون فرصة تدميرها أكتر من ال
+
+675
+00:48:26,230 --> 00:48:29,330
+embryo لأن ال embryo عنده resistant عالية ال
+
+676
+00:48:29,330 --> 00:48:33,770
+oocyte sensitive عشان كده معظم المراكز بيميلوا إلى
+
+677
+00:48:33,770 --> 00:48:37,890
+تجميد الأجنة و ليس إلى تجميد البويضة لأن البويضة
+
+678
+00:48:37,890 --> 00:48:41,910
+بين لحظة و تانية ممكن تتلفبينما الأجنة مقاومتها
+
+679
+00:48:41,910 --> 00:48:45,450
+للتلف بفعل ال cryopreservation بتكون أعلى يعني ال
+
+680
+00:48:45,450 --> 00:48:49,910
+survival rate تبعتها أعلى slow rate of freezing
+
+681
+00:48:49,910 --> 00:48:53,730
+attempt to control biophysical properties of
+
+682
+00:48:53,730 --> 00:48:57,730
+freezing such as a cooling and warming grade in
+
+683
+00:48:57,730 --> 00:49:02,710
+conjunction with cryoprotectant to minimize advice
+
+684
+00:49:02,710 --> 00:49:08,210
+cellular even يعني فكرة slow freezing methodهي
+
+685
+00:49:08,210 --> 00:49:13,210
+طريقة تعتمد على التحكم في درجات انخفاض الحرارة
+
+686
+00:49:13,210 --> 00:49:17,430
+ودرجات ارتفاع الحرارة اعتمادًا على كمية الـ
+
+687
+00:49:17,430 --> 00:49:21,150
+cryoprotectant الموجودة من أجل تقليل التأثير
+
+688
+00:49:21,150 --> 00:49:25,850
+السلبي الخاص بالـ cellular event اللي بتحدث خلال
+
+689
+00:49:25,850 --> 00:49:30,630
+عملية الـ cryopreservation في الـ slow freezing
+
+690
+00:49:30,630 --> 00:49:35,030
+method بيصير cooling للخلايا to very low
+
+691
+00:49:35,030 --> 00:49:38,650
+temperaturecirculating الخلايا لدرجة حرارة مخاطرة
+
+692
+00:49:38,650 --> 00:49:43,490
+جدا قد تصل إلى minus 30 كعدد درجة الحرارة التي يتم
+
+693
+00:49:43,490 --> 00:49:46,590
+تناقصها في الدقيقة الواحدة while minimizing
+
+694
+00:49:46,590 --> 00:49:50,430
+intracellular ice crystal formation and at the
+
+695
+00:49:50,430 --> 00:49:52,990
+same time attempt to minimize the harmful
+
+696
+00:49:52,990 --> 00:49:56,390
+influence of increased salient concentration and
+
+697
+00:49:56,390 --> 00:50:00,730
+osmotic stress إذن في ال slow freezing method هي
+
+698
+00:50:00,730 --> 00:50:06,150
+طريقة تعمل على تبريد الخلايالكي تصل إلى درجة حرارة
+
+699
+00:50:06,150 --> 00:50:10,770
+منخفضة جدا جدا بشرط أن تحافظ على الـfunctional of
+
+700
+00:50:10,770 --> 00:50:16,290
+oocyte or embryo تقلل من تأثير التركيز المرتفعة
+
+701
+00:50:16,290 --> 00:50:21,230
+للمواد التي تستخدم و التي تؤدي إلى إطلاف الخلية
+
+702
+00:50:21,230 --> 00:50:25,510
+بالإضافة إلى تقليل التأثير السلبي للـosmotic
+
+703
+00:50:25,510 --> 00:50:29,610
+stress الـvetrification بيصير في عندي مش slow
+
+704
+00:50:29,610 --> 00:50:32,850
+freezing لأ rapid freezing انه بيصير عملية cooling
+
+705
+00:50:32,850 --> 00:50:38,050
+سريع جداباستخدام تركيز عالمي الـ cryoprotectant
+
+706
+00:50:38,050 --> 00:50:43,290
+that solidified without forming ice crystal يعني
+
+707
+00:50:43,290 --> 00:50:47,450
+الventrification تبريد سريع جدا باستخدام تركيز
+
+708
+00:50:47,450 --> 00:50:51,090
+عالمي الـ cryoprotectant منع تكوين ال ice crystal
+
+709
+00:50:51,090 --> 00:50:56,070
+هناخد ايش الفرق بين كل طريقة او اخرى على سبيل
+
+710
+00:50:56,070 --> 00:50:59,230
+المثال، ان verification تقنيكي ال oocyte و ال
+
+711
+00:50:59,230 --> 00:51:04,070
+embryo بصيرها dehydrationقبل عملية ال cooling من
+
+712
+00:51:04,070 --> 00:51:07,870
+خلال تعريضها إلى concentrating solution of the
+
+713
+00:51:07,870 --> 00:51:11,570
+cribrotectin before plugging the sample directly
+
+714
+00:51:11,570 --> 00:51:14,310
+into liquid nitrogen بمعنى آخر أنه أنا بجيب
+
+715
+00:51:14,310 --> 00:51:18,250
+البويضة البويضة بحضنها مع تركيز عالي من
+
+716
+00:51:18,250 --> 00:51:23,950
+cribrotectin بيخليها بيصلها dehydration بعدين باخد
+
+717
+00:51:23,950 --> 00:51:27,250
+البويضة و بلقيهافي الـ liquid nitrogen طبعا مش
+
+718
+00:51:27,250 --> 00:51:30,510
+بلقيها بلقيها بعد الشكل لأ فيها طريقة معينة انه
+
+719
+00:51:30,510 --> 00:51:34,710
+بستخدمها في حاجة بتسميها strip هنشوفها كمان شوية
+
+720
+00:51:34,710 --> 00:51:40,650
+زي الحاضنة طبعا كيف عملية ال freezing بتتم with
+
+721
+00:51:40,650 --> 00:51:44,830
+low cooling rate تصل إلى point three لكل دقيقة
+
+722
+00:51:44,830 --> 00:51:48,850
+يعني بيصير عملية اخفاض درجة حرارة point تلاتة درجة
+
+723
+00:51:48,850 --> 00:51:55,130
+لكل دقيقة to about minus30 سلسيوس لـ 40 سلسيوس
+
+724
+00:51:55,130 --> 00:52:02,030
+تتبع بإزالة حرارة الهواء لـ-50 سلسيوس في ساعة
+
+725
+00:52:02,030 --> 00:52:10,470
+لتحرير من الـ-80 سلسيوس لـ-150 سلسيوس قبل البداية
+
+726
+00:52:10,470 --> 00:52:14,430
+الانفجار بالنيتوجين الليلي يعني بصير عندي اخفاض
+
+727
+00:52:14,430 --> 00:52:19,800
+وانخفاض تدريجي في درجة الحرارةمن سالب تلاتين لسالب
+
+728
+00:52:19,800 --> 00:52:24,860
+أربعين كل دقيقة بعدين بيرتفع من سالب خمسين لسالب
+
+729
+00:52:24,860 --> 00:52:28,380
+سالب خمسين لكل دقيقة بعدين بيصير من سالب تمانين
+
+730
+00:52:28,380 --> 00:52:33,240
+لسالب مية وخمسين لكل دقيقة شوف جديش عملية انخفاض
+
+731
+00:52:33,240 --> 00:52:37,700
+درجة الحرارة معدل انخفاضها طبعا لازم تصل لسالب مية
+
+732
+00:52:37,700 --> 00:52:42,540
+وخمسين درجة قبل إلقاء في ال liquid nitrogen طيب
+
+733
+00:52:42,540 --> 00:52:47,210
+خلال ال during او خلال slow coolingبصير
+
+734
+00:52:47,210 --> 00:52:50,130
+dehydration وبعدين بصير عندى حاجة بتسميها
+
+735
+00:52:50,130 --> 00:52:56,230
+continuous reduction for oocyte temperature أو
+
+736
+00:52:56,230 --> 00:53:01,610
+خلّيني أسميه continuous reduction for temperature
+
+737
+00:53:01,610 --> 00:53:06,840
+قد تصل إلى ماينس تلاتين درجة after whichany
+
+738
+00:53:06,840 --> 00:53:12,060
+remaining water is super cooling هذا عبارة عن
+
+739
+00:53:12,060 --> 00:53:15,400
+العملية يعني بيصير خلال slow cooling بيصير في عندي
+
+740
+00:53:15,400 --> 00:53:19,800
+dehydration للفويدة وبعدين بيصير عندي خفض لدرجة
+
+741
+00:53:19,800 --> 00:53:24,940
+الحرارة بشكل مستمر بمعدل سالب تلاتين قبل ما انا
+
+742
+00:53:24,940 --> 00:53:29,640
+استخدم ال liquid نيتروجين فيها اذا هذه فكرة ال
+
+743
+00:53:29,640 --> 00:53:31,980
+cooling slow cooling او ال vitrification
+
+744
+00:53:35,900 --> 00:53:40,480
+الـ Embryo and oocyte cooled slowly to sub-zero
+
+745
+00:53:40,480 --> 00:53:45,140
+temperature of minus 30 to minus 40 Celsius before
+
+746
+00:53:45,140 --> 00:53:51,780
+rapidly cooling to arrive minus 196 Celsius
+
+747
+00:53:51,780 --> 00:53:55,520
+required rapidly warming thawing in warm water of
+
+748
+00:53:55,520 --> 00:54:00,400
+25 Celsius to 37 Celsius يعني بيقوللي ببساطة اللي
+
+749
+00:54:00,400 --> 00:54:05,560
+ال embryo هتخضع إلى عملية التبريد التدريجي والبطير
+
+750
+00:54:05,820 --> 00:54:10,600
+لكي تصل إلى درجة حرارة أقل من السفر أو تحت السفر
+
+751
+00:54:10,600 --> 00:54:15,340
+تصل إلى سالب تلاتين بعدين سالب أربعين بعدين تستمر
+
+752
+00:54:15,340 --> 00:54:18,880
+في التناقص بشكل تدريجي لتصل إلى سالب مية وستة
+
+753
+00:54:18,880 --> 00:54:24,120
+وتسعين درجة مائوية وهي في الغالب درجة حرارة liquid
+
+754
+00:54:24,120 --> 00:54:28,140
+nitrogen liquid nitrogen درجة حرارته سالب مية وستة
+
+755
+00:54:28,140 --> 00:54:32,720
+وتسعين درجة مائوية طبعا خلال هذه العملية خلاص
+
+756
+00:54:32,720 --> 00:54:36,780
+اتجمدت البويضةبدأ أرجع عملها thawing لازم أضيفه أو
+
+757
+00:54:36,780 --> 00:54:42,340
+أوضعها في حمام مائي بصل درجة حرارته 25 إلى 37 درجة
+
+758
+00:54:42,340 --> 00:54:46,980
+معوية Rapid thawing is followed by remove the CPA
+
+759
+00:54:46,980 --> 00:54:51,800
+from the embryo and oocyte شو بيصير و شو بيحدث
+
+760
+00:54:51,800 --> 00:54:56,960
+خلال عملية ال thawing بتم عملية إزالة و إخراج ال
+
+761
+00:54:56,960 --> 00:55:00,160
+cryoprotective agent الموجود داخل ال embryo أو
+
+762
+00:55:00,160 --> 00:55:03,500
+الموجود داخل البوادة أو التخلص منههيحل محله مين؟
+
+763
+00:55:03,500 --> 00:55:07,060
+هيحل محله الماء لأنه في الـ cryopreservation الماء
+
+764
+00:55:07,060 --> 00:55:11,620
+طلع ودخل مكانه الـCPA في الـthawing الـCPA بيطلع
+
+765
+00:55:11,620 --> 00:55:15,480
+وتحل محله الماء تحت مصطلح الـrehydration
+
+766
+00:55:15,480 --> 00:55:18,780
+rehydration of the cell is carried out in
+
+767
+00:55:18,780 --> 00:55:22,400
+increasing concentration of permitting CPA
+
+768
+00:55:22,400 --> 00:55:25,480
+generally in the presence of increased
+
+769
+00:55:25,480 --> 00:55:29,140
+concentration of non-permitting CPA إذا في عملية
+
+770
+00:55:29,140 --> 00:55:33,090
+الـthawingيعبارة عن عملية بنسميها Rehydration حيث
+
+771
+00:55:33,090 --> 00:55:38,810
+تبنزع وإخراج الـCPA ويحل محله الماء كما كانت
+
+772
+00:55:38,810 --> 00:55:44,790
+الخلية فيما سبق ال Petrification وهي المصطلح الآخر
+
+773
+00:55:44,790 --> 00:55:49,210
+اللي سموه Ultra Rapid Cryopreservation أول ما تم
+
+774
+00:55:49,210 --> 00:55:54,990
+استخدامه كان في بداية أو في منتصف عام 1980هي طريقة
+
+775
+00:55:54,990 --> 00:55:58,630
+تختلف بشكل كبير جدا عن slow freezing method يتم
+
+776
+00:55:58,630 --> 00:56:02,170
+فيها تجنب تكوين ال ice crystal in the
+
+777
+00:56:02,170 --> 00:56:06,290
+intracellular and extracellular space يعني مش فقط
+
+778
+00:56:06,290 --> 00:56:11,020
+بمنع تكوين ال ice crystalفي داخل الخلية الـ
+
+779
+00:56:11,020 --> 00:56:13,680
+Intracellular كمان بيعمل منع تكوينه في الـ
+
+780
+00:56:13,680 --> 00:56:19,120
+Extracellular في الـ Vitrification عملية يتم فيها
+
+781
+00:56:19,120 --> 00:56:23,260
+ببساطة إخفاء درجة الحرارة ومنع تكوين الـ ice
+
+782
+00:56:23,260 --> 00:56:28,500
+crystal من خلال الحصول و استخدام تركيز عالي من
+
+783
+00:56:28,500 --> 00:56:34,010
+الـCPA يصل إلى من 4 إلى 8 مول per literوتعريضها
+
+784
+00:56:34,010 --> 00:56:39,330
+لعملية التبريد السريع يعني ممكن تنزل لـ-196 خلال 3
+
+785
+00:56:39,330 --> 00:56:43,870
+دقائق فقط لغاية ماتاخدلاش ساعة أو ساعتين خلال ال
+
+786
+00:56:43,870 --> 00:56:48,090
+vitrification بيصير dehydration للبوايضة أو الجنين
+
+787
+00:56:48,090 --> 00:56:52,690
+قبل ما تتعرض إلى ال liquid nitrogen من خلال
+
+788
+00:56:52,690 --> 00:56:56,610
+تحضيرها مع تركيز علمي من ال CBA وهو ال
+
+789
+00:56:56,610 --> 00:57:01,060
+cryopreservating agentطبعاً في عندي potential risk
+
+790
+00:57:01,060 --> 00:57:03,260
+associated with the fertification procedure is the
+
+791
+00:57:03,260 --> 00:57:07,200
+high concentration of CPA بس بالإضافة إلى ال
+
+792
+00:57:07,200 --> 00:57:09,600
+toxicity اللي خاصة فيها يعني نفس ال factor اللي
+
+793
+00:57:09,600 --> 00:57:12,220
+ممكن يتأثر على نتيجة slow freezing هي نفس ال
+
+794
+00:57:12,220 --> 00:57:13,900
+factor اللي ممكن يتأثر على نتيجة ال
+
+795
+00:57:13,900 --> 00:57:16,480
+fertilification و هي عبارة عن التركيز العالية
+
+796
+00:57:16,480 --> 00:57:20,520
+للمواد الحافظة لإضافة إلى ال toxicity اللي خاصة
+
+797
+00:57:20,520 --> 00:57:24,220
+بها ال toxicity اللي خاصة بها ممكن أنا أعمل
+
+798
+00:57:24,220 --> 00:57:29,050
+limitation لهذا التأثير من خلال damageمراكبين مع
+
+799
+00:57:29,050 --> 00:57:33,350
+بعض من بعض، عمل mixing ل two compounds هذا بعمل
+
+800
+00:57:33,350 --> 00:57:38,190
+reducing the toxicity أو من خلال تقليل الوقت
+
+801
+00:57:38,190 --> 00:57:42,610
+اللازم أو وقت تعرض البويضة أو الجنين لهذه المواد،
+
+802
+00:57:42,610 --> 00:57:46,630
+لل-CPA يعني بدل ما أخليها عشر دقائق، بخليها خمس
+
+803
+00:57:46,630 --> 00:57:52,310
+دقائقطبعاً في بعض البرتقالات ميديا البرتقالات هي
+
+804
+00:57:52,310 --> 00:57:56,630
+ايضا مدعومة مع ميكرو مليكيول مثل بولي إيثيلين
+
+805
+00:57:56,630 --> 00:58:02,310
+إيجليكول أو بولي أو PVP بعض الأحيان الميديا أو
+
+806
+00:58:02,310 --> 00:58:05,090
+المواد ال CBA التي تستخدم في البرتقالات بتكون
+
+807
+00:58:05,090 --> 00:58:08,410
+مخلوطة بالميكرو مليكيول زي ال PVP وهي الميديا التي
+
+808
+00:58:08,410 --> 00:58:13,190
+استخدمت في إمبوليزاショن of spermatozoa أو استخدام
+
+809
+00:58:13,190 --> 00:58:18,000
+بولي إيثيلين إيجليكول فهي عبارةعن مواد بتعمل
+
+810
+00:58:18,000 --> 00:58:21,420
+increasing للviscosity the macromolecules support
+
+811
+00:58:21,420 --> 00:58:24,460
+vitrification with low concentration of CBA هذا
+
+812
+00:58:24,460 --> 00:58:28,620
+بتعمل زيادة للviscosity فبالتالي بتحتل مساحة أكبر
+
+813
+00:58:28,620 --> 00:58:33,300
+إضافة إلى بتعمل reduction لل toxicity level الخاصة
+
+814
+00:58:33,300 --> 00:58:38,340
+بال CBA طريقة بتوضح الكلام اللي أنا قلته في ال
+
+815
+00:58:38,340 --> 00:58:42,240
+vitrification أول حاجة باخد البويضة أو ال embryo
+
+816
+00:58:42,240 --> 00:58:45,960
+بعد اليوم التالت أو بعد اليوم الرابعبعمله
+
+817
+00:58:45,960 --> 00:58:48,980
+hybridization أو بعمله mixing أو بعمله incubation
+
+818
+00:58:48,980 --> 00:58:53,020
+مع الـCPA لمدة عشر دقائق أو عشرين دقيقة بناء على
+
+819
+00:58:53,020 --> 00:58:58,720
+ال protocol المستخدة هذه العملية بنسميها hydration
+
+820
+00:58:58,720 --> 00:59:03,720
+بعدين باخد البويضة أو ال embryo بضيفها في منطقة
+
+821
+00:59:03,720 --> 00:59:08,140
+بسميها small amount of cryoprotectant on the
+
+822
+00:59:08,140 --> 00:59:13,780
+cryovial بمعنى آخر أنه أنا حضنتها باخدالبوايضة
+
+823
+00:59:13,780 --> 00:59:19,420
+اللى موجودة في الـ Cups هذا بالـ Aspiration needle
+
+824
+00:59:19,420 --> 00:59:24,220
+بضيفها على .. في الـ catheter و بضيف عليها جزء من
+
+825
+00:59:24,220 --> 00:59:28,200
+ال media اللى أنا استخدمتها بعد كده باخد ال
+
+826
+00:59:28,200 --> 00:59:31,460
+catheter اللى أنا ضفط فيها البوايضة طبعا هذا كله
+
+827
+00:59:31,460 --> 00:59:33,560
+تحت الميكروسكوب بيصير يعني هذه العملية تحت
+
+828
+00:59:33,560 --> 00:59:36,100
+الميكروسكوب و هذه العملية تحت الميكروسكوب الوحيدة
+
+829
+00:59:36,100 --> 00:59:38,860
+اللى بتكون خارج الميكروسكوب عامل لإن ما بقدر أشوف
+
+830
+00:59:38,860 --> 00:59:41,880
+ال catheter و رفع ال catheter و العلامة اللى ..
+
+831
+00:59:42,070 --> 00:59:47,110
+محدد أضيف فيها ال egg أو ال oocyte بشكل سليم بعمل
+
+832
+00:59:47,110 --> 00:59:52,390
+عملية removing لل catheter و بعملها عملية putting
+
+833
+00:59:52,390 --> 00:59:56,250
+في ال liquid nitrogen لفترة زمنية معينة تقدر
+
+834
+00:59:56,250 --> 00:59:59,250
+بتلاتين ثانية اربعين ثانية بناء على ال protocol
+
+835
+00:59:59,250 --> 01:00:03,750
+المستخدم اذا shift it into liquid nitrogen where
+
+836
+01:00:03,750 --> 01:00:09,490
+high velocity cooling or rapid cooling for the
+
+837
+01:00:09,490 --> 01:00:13,550
+oocyte enable the eggto arrive vitrification stage
+
+838
+01:00:13,550 --> 01:00:18,330
+بعد كده باخد ال catheter هذه و بضيفه في ال tank of
+
+839
+01:00:18,330 --> 01:00:23,350
+liquid nitrogen لفترة زمنية اللي انا بحتاجها for
+
+840
+01:00:23,350 --> 01:00:26,990
+the next cycle هذه طريقة ال vitrification بشكل
+
+841
+01:00:26,990 --> 01:00:30,490
+بسيط خليني اشوف الفيديو اللي بتكلم عن هذا الموضوع
+
+842
+01:00:30,490 --> 01:00:33,850
+و كيف بتصير عملية ال vitrification
+
+843
+01:00:56,360 --> 01:00:58,620
+طبعا ال video notification بيكون عبارة عن زي كت
+
+844
+01:00:58,620 --> 01:01:00,020
+خاص فيها هذه ال catheter
+
+845
+01:01:27,190 --> 01:01:32,170
+طبعا بعدد أهميتها و إيش الوظائف المطلوبة منها أو
+
+846
+01:01:32,170 --> 01:01:37,510
+كيف بتقوم بهذه العملية طبعا في منها أنواع ما
+
+847
+01:01:37,510 --> 01:01:41,470
+بيعنينا الكلام هذا كله خلينا نشوف كيف عملية
+
+848
+01:01:41,470 --> 01:01:47,270
+العملية بتصير هي بهذا الشكل بدأ عملية إخراج ال
+
+849
+01:01:47,270 --> 01:01:53,870
+catheter أو إخراج ال strip خليني أسميهبضيف الـ
+
+850
+01:01:53,870 --> 01:01:58,030
+Label عليها علشان ما يصير عملية interference في
+
+851
+01:01:58,030 --> 01:02:08,090
+البيانات الـ ID الـ forceps بيخرج جزء منها طبعاً
+
+852
+01:02:08,090 --> 01:02:13,550
+بحطها في الـ Liquid nitrogen تحت
+
+853
+01:02:13,550 --> 01:02:19,070
+الميكروسكوب هياخد قلب ويدة هيضيفها ويعملها holding
+
+854
+01:02:19,070 --> 01:02:24,270
+على الـ strip الموجودأو الـ Straw في بعض الأحيان
+
+855
+01:02:24,270 --> 01:02:28,070
+بيسموها طبعا في لمكان محدد هذي بيسموها الزرجة
+
+856
+01:02:28,070 --> 01:02:33,910
+بيسموها ال Straw أو ال Strip بعد
+
+857
+01:02:33,910 --> 01:02:43,730
+كده لازم يعمل عملية إدخال للمحتوى في داخل و بلفها
+
+858
+01:02:43,730 --> 01:02:49,070
+عشان يسكرها كده عمل petrification ببساطة جدا كيف
+
+859
+01:02:49,070 --> 01:02:50,070
+بيعملها warming؟
+
+860
+01:02:55,240 --> 01:03:00,540
+عشان يعمل flowing يعني طبعا
+
+861
+01:03:00,540 --> 01:03:05,840
+في ال liquid nitrogen بيلفها لف عكسي علشان يفكها و
+
+862
+01:03:05,840 --> 01:03:09,260
+بيسحبها و بنتظر شوية في ال liquid nitrogen عشان
+
+863
+01:03:09,260 --> 01:03:13,980
+مايصير الشكلها و بعدين بنقلها على ال media الخاصة
+
+864
+01:03:13,980 --> 01:03:17,080
+فيها عشان كده ال vitrification تعتبر أسهل الطرق
+
+865
+01:03:17,080 --> 01:03:20,080
+التي تستخدمها مقارنة بسيطة بين ال slow freezing و
+
+866
+01:03:20,080 --> 01:03:23,060
+ال vitrificationالـ damage بيصير في ال low
+
+867
+01:03:23,060 --> 01:03:26,300
+freezing مافيش في ال vitrification دمج ل ال oocyte
+
+868
+01:03:26,300 --> 01:03:29,680
+من خلال تكوين ال ice crystal ال speed of freezing
+
+869
+01:03:29,680 --> 01:03:37,020
+تقدر ب 0.3 درجة
+
+870
+01:03:37,020 --> 01:03:40,100
+لكل minute في ال slow freezing و ال vitrification
+
+871
+01:03:40,100 --> 01:03:43,940
+بتصل ل 23 درجة لكل دقيقة بيصير reduction في ال
+
+872
+01:03:43,940 --> 01:03:48,270
+temperatureالـ Pre-protectant amounted very low،
+
+873
+01:03:48,270 --> 01:03:51,370
+very high في ال vitrification، ال survival rate
+
+874
+01:03:51,370 --> 01:03:56,070
+very low في ال slow freezing، في ال vitrification
+
+875
+01:03:56,070 --> 01:03:58,830
+عالية، ال procedure very simple في ال slow
+
+876
+01:03:58,830 --> 01:04:02,390
+freezing، في ال vitrification complex، لأنها
+
+877
+01:04:02,390 --> 01:04:07,490
+بتعتمد على الدقة والتركيز بشكل كبير جداطبعا ال
+
+878
+01:04:07,490 --> 01:04:10,930
+duration تأخد second ال vitrification slow
+
+879
+01:04:10,930 --> 01:04:14,190
+freezing ممكن تأخد ساعات control of dehydration
+
+880
+01:04:14,190 --> 01:04:16,910
+rate موجودة في ال vitrification مش موجودة في ال
+
+881
+01:04:16,910 --> 01:04:20,750
+slow freezing ال duration out of incubator عشرة
+
+882
+01:04:20,750 --> 01:04:22,950
+منت في ال vitrification تلاتة hour في ال slow
+
+883
+01:04:22,950 --> 01:04:27,050
+freezing زونة في اليوسيطة تصير تدمير في ال
+
+884
+01:04:27,050 --> 01:04:30,790
+vitrification لأ في ال slow freezing maybe ال
+
+885
+01:04:30,790 --> 01:04:33,950
+equipment and running cost inexpensive في ال
+
+886
+01:04:33,950 --> 01:04:38,250
+vitrification very expensiveتحتاج إلى machine ال
+
+887
+01:04:38,250 --> 01:04:42,050
+slow freezing في هذا القدر نكون قد أنهينا هذه
+
+888
+01:04:42,050 --> 01:04:47,230
+المحاضرة و أنهينا إلى حد ما معظم ال topics اللي
+
+889
+01:04:47,230 --> 01:04:51,350
+احنا اتوقعنا و كنا نحكي عليها خلال هذه المحاضرة
+
+890
+01:04:51,350 --> 01:04:56,550
+نرجو لكم التوفيق دائما و دمتم في حفظنا و رعايتنا
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/dsOa0-DLeoA_raw.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/dsOa0-DLeoA_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..4d6ea0305be2b41d461e3b60818f1366d6a9b6cf
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/dsOa0-DLeoA_raw.srt
@@ -0,0 +1,3560 @@
+1
+00:00:01,080 --> 00:00:05,080
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:05,080 --> 00:00:10,620
+المرسلين سيدنا محمد وعلى آله وصحبه أجمعين طلابنا
+
+3
+00:00:10,620 --> 00:00:14,900
+الأفاضل نرجو من الله أن تكونوا جميعا بخير وبصحة
+
+4
+00:00:14,900 --> 00:00:19,860
+جيدة اليوم سوف ننتقل إلى chapter جديد يتحدث عن ال
+
+5
+00:00:19,860 --> 00:00:24,260
+embryo transfer and implantation سوف نتحدث في هذا
+
+6
+00:00:24,260 --> 00:00:29,020
+ال chapter عن آلية نقل ال embryo ما هو الجنين الذي
+
+7
+00:00:29,020 --> 00:00:34,260
+ينقلكيف يكون تقييم الجنين بناء على الضوابط المعمول
+
+8
+00:00:34,260 --> 00:00:38,060
+فيها في مختبرات التلقيح الصناعي؟ ما معنى
+
+9
+00:00:38,060 --> 00:00:41,900
+implantation؟ كيف تحدث عملية الـ implantation؟
+
+10
+00:00:41,900 --> 00:00:45,000
+بالإضافة إلى الانتقال إلى موضوع الـ
+
+11
+00:00:45,000 --> 00:00:49,820
+cryopreservation كان مبدأ مختصرا بسيطا عن آلية
+
+12
+00:00:49,820 --> 00:00:54,160
+تجميد الأجنة وتجميد البويضات طبعا هذا ال chapter
+
+13
+00:00:54,160 --> 00:00:57,760
+هيكون هو ال chapter الأخير في هذا المصاق ان شاء
+
+14
+00:00:57,760 --> 00:01:03,450
+اللهنبدأ على بركة الله بداية عملية ال implantation
+
+15
+00:01:03,450 --> 00:01:08,930
+ببساطة جدا هي عبارة عن عملية يتم فيها انغراس
+
+16
+00:01:08,930 --> 00:01:13,830
+الجنين المنقول بعد عملية التلقيح التي حدثت في
+
+17
+00:01:13,830 --> 00:01:19,310
+المختبر إلى رحم الأنثى أو رحم السيدة هذا الانغراس
+
+18
+00:01:19,310 --> 00:01:23,930
+يؤدي إلى تشابك ما بين الجنين وبين ال endomaterial
+
+19
+00:01:23,930 --> 00:01:28,070
+service الموجودة في رحم السيدة وهي التي تعرف باسم
+
+20
+00:01:28,370 --> 00:01:33,110
+بقنط الرحم مما يؤدي في النهاية إلى تكوين لبلاسنتا
+
+21
+00:01:33,110 --> 00:01:36,730
+التي تكون عبارة عن حلقة الوصل ما بين الدورة
+
+22
+00:01:36,730 --> 00:01:40,690
+الدموية الخاصة بالجنين والدورة الدموية الخاصة
+
+23
+00:01:40,690 --> 00:01:45,760
+بالأم والتي تكون بمثابة البوابةالتي من خلالها يحدث
+
+24
+00:01:45,760 --> 00:01:49,740
+تبادل المواد الغذائية التي يحتاج إليها الجنين
+
+25
+00:01:49,740 --> 00:01:54,780
+بالإضافة إلى الوكسوجين وخلافه كما نعرف بلاسنتا
+
+26
+00:01:54,780 --> 00:01:58,900
+that will provide an interference between growing
+
+27
+00:01:58,900 --> 00:02:02,120
+fetus and maternal circulation the human
+
+28
+00:02:02,120 --> 00:02:06,640
+endomaterium undergo a complex series of organized
+
+29
+00:02:07,790 --> 00:02:12,870
+هذه الـ endomaterium الموجودة في الرحم و التي سميت
+
+30
+00:02:12,870 --> 00:02:17,750
+بالنقطة الرحم خلال عملية ال ovulation إذا بدأنا من
+
+31
+00:02:17,750 --> 00:02:22,690
+البداية مرورا ب fertilization إذا كان الأمر طبيعي
+
+32
+00:02:22,690 --> 00:02:27,690
+تخضع إلى العديد من التغيرات التي تجعل خلايا ال
+
+33
+00:02:27,690 --> 00:02:33,510
+endomaterium أكثر نموأكثر سماكة، أكثر تقبلًا
+
+34
+00:02:33,510 --> 00:02:39,370
+لإستقبال الجنين الذي سوف ينغرس في هذه البطانة مما
+
+35
+00:02:39,370 --> 00:02:44,110
+يؤدي إلى تكوين الـ placenta التي تكون ناشع عن وجود
+
+36
+00:02:44,110 --> 00:02:49,070
+جنين جديد تم انغراسه في منطقة البطانة الرحلة هذه
+
+37
+00:02:49,070 --> 00:02:53,710
+التغيرات ممكن تكون تغيرات لها علاقة بكمية blood
+
+38
+00:02:53,710 --> 00:02:57,390
+supply التي تصل إلى هذه المنطقة كمية البوتينات
+
+39
+00:02:57,390 --> 00:03:01,410
+التي تفرزكمية الـ Transporter Material أو الـ
+
+40
+00:03:01,410 --> 00:03:04,590
+Transporter Protein التي تبدأ في المهاجرة إلى هذا
+
+41
+00:03:04,590 --> 00:03:09,630
+المكان بالإضافة إلى كمية الغرمونات التي تفرز بحدد
+
+42
+00:03:09,630 --> 00:03:14,510
+معين من أجل المساهمة في بناء بطاقة الرحم ومن أجل
+
+43
+00:03:14,510 --> 00:03:18,230
+المساهمة في إنجاح عملية ال implantation فبالتالي
+
+44
+00:03:18,230 --> 00:03:23,870
+هذه العملية عملية مهمة جدا عملية نمو بطاقة الرحم
+
+45
+00:03:23,870 --> 00:03:26,970
+فبالتالي عملية الانغراس أو عملية ال implantation
+
+46
+00:03:27,220 --> 00:03:32,520
+ليس عملية عشوائية تحدث بسبب فعل واحد أو حدث واحد
+
+47
+00:03:32,520 --> 00:03:37,100
+إنما هي عبارة عن أحداث متراكمة تؤدي في النهاية إلى
+
+48
+00:03:37,100 --> 00:03:41,320
+حدوث ال implantation in a human during normal
+
+49
+00:03:41,320 --> 00:03:45,060
+cycle for example ال embryo will be enter in the
+
+50
+00:03:45,060 --> 00:03:49,580
+uterine cavity in the four day after ovulation في
+
+51
+00:03:49,580 --> 00:03:53,330
+الوضع الطبيعيإذا صار عندى fertilization طبيعي
+
+52
+00:03:53,330 --> 00:03:57,450
+المفروض ال embryo إذا تم تلقيحه بشكل طبيعي في قناة
+
+53
+00:03:57,450 --> 00:04:02,010
+Fallopian tube هيصل إلى الرحل بعد أربع أيام من
+
+54
+00:04:02,010 --> 00:04:06,750
+عملية ال ovulation عشان كده حكينا إن البويضة
+
+55
+00:04:06,750 --> 00:04:11,430
+تستغرط تلت أيام كحد أقصى علشان تقطع منطقة ال
+
+56
+00:04:11,430 --> 00:04:16,730
+fallopian tube وصولا إلى اليوتران وعلشان كده حكينا
+
+57
+00:04:16,730 --> 00:04:22,120
+إنهعملية إرجاع الأجنة في عملية الحقن المجهري تحدث
+
+58
+00:04:22,120 --> 00:04:27,140
+بعد تلت أيام كحد أدنى أو خمس أيام كحد أقصى إذا
+
+59
+00:04:27,140 --> 00:04:30,540
+بتتذكر اللغة اللي حكينا عن الـBGD كانت بيصير
+
+60
+00:04:30,540 --> 00:04:35,580
+embryo transfer ال
+
+61
+00:04:35,580 --> 00:04:38,600
+endomaterium become receptive
+
+62
+00:04:41,190 --> 00:04:47,430
+أقل من 6 أيام بعد الوفيوليشيا ويبقى مستمع ل 4 أيام
+
+63
+00:04:47,430 --> 00:04:54,730
+سيكل 22-24 أي دورة شهرية أبيعية منتظمة عند السيدة
+
+64
+00:04:54,730 --> 00:04:59,890
+معناه أن الهندو ماتيريام هتكون قابلة لاستقبال و
+
+65
+00:04:59,890 --> 00:05:03,010
+قادرة على استقبال لبلاستوسيست وهي عبارة عن
+
+66
+00:05:03,010 --> 00:05:06,050
+الامبريو بعد ما اتحول من موريلا إلى بلاستوسيست
+
+67
+00:05:06,050 --> 00:05:13,320
+خلال 6 أيام على الأقل بعد الوفيوليشيابينما تبقى
+
+68
+00:05:13,320 --> 00:05:17,160
+بعد 6 أيام قادرة على استقبال الجنين حتى 4 أيام،
+
+69
+00:05:17,160 --> 00:05:21,320
+يعني بمعنى آخر تستطيع الـ endomaterial أن تحتفظ
+
+70
+00:05:21,320 --> 00:05:28,080
+بقابلتها لاستقبال الجنين من 6 إلى 4 أيام، total
+
+71
+00:05:28,080 --> 00:05:32,650
+عشر أيام من لحظة الوفيولوجياعشان كده حكينا إنه في
+
+72
+00:05:32,650 --> 00:05:36,950
+ال XE أو ال IVF عملية ال import transfer ممكن تحدث
+
+73
+00:05:36,950 --> 00:05:39,990
+في اليوم التاني و التالت و الرابع و الخامس و
+
+74
+00:05:39,990 --> 00:05:44,270
+السادس طبعا هذا إيش بتحكم فيها؟ بتحكم عدد الخلايا
+
+75
+00:05:44,270 --> 00:05:48,230
+اللي انقسمت داخل الجنين متى وصلت إلى مرحلة ال
+
+76
+00:05:48,230 --> 00:05:53,150
+plasticest هل تحتاج إلى عمل PGD ولا لأ؟ ماء ان
+
+77
+00:05:53,150 --> 00:05:56,770
+طبيعة الفحوصات الوراثية اللتي سوف تحدث على هذا
+
+78
+00:05:56,770 --> 00:06:00,750
+الجنينهل تستغرق وقت طويل؟ يومين، تلاتة؟ فبالتالي
+
+79
+00:06:00,750 --> 00:06:06,930
+أنا هنتظر نتيجة ظهور الـBGD as genetic testing
+
+80
+00:06:06,930 --> 00:06:10,270
+وبناء عليه أقرر أرجع أي جنين عشان كده ممكن أرجع
+
+81
+00:06:10,270 --> 00:06:13,090
+الجنين في اليوم الخامس، في اليوم السادس فسبحان
+
+82
+00:06:13,090 --> 00:06:16,710
+الله أن الـEndometrium لها قابلية أن تستقبل جنين
+
+83
+00:06:16,710 --> 00:06:20,170
+لمدة ست أيام، ست أيام بالضبط بعد الـovulation
+
+84
+00:06:20,170 --> 00:06:24,530
+واضيف عليهم كمان أربع أيام اضيف عليهم كمان أربع
+
+85
+00:06:24,530 --> 00:06:27,390
+أيام when implantation does not occurمافي
+
+86
+00:06:27,390 --> 00:06:30,610
+implantation صار fertilization ومافي implantation
+
+87
+00:06:30,610 --> 00:06:34,850
+ماصار fertilization معناه انه خلاص ال endomaterium
+
+88
+00:06:34,850 --> 00:06:38,250
+هتبدأ عملية ال destruction و we are removing as
+
+89
+00:06:38,250 --> 00:06:42,330
+bleeding تحت مصطلح الدورة او ال menstrual cycle
+
+90
+00:06:42,330 --> 00:06:46,390
+هذا اللي بيصير في وضعه الطبيعي طيب السؤال هل ال
+
+91
+00:06:46,390 --> 00:06:50,430
+implantation تحدث بشكل عابر؟ هل ال implantation
+
+92
+00:06:50,430 --> 00:06:55,180
+تحدث بفعل حدث واحد ام احداث متتالية؟To achieve
+
+93
+00:06:55,180 --> 00:06:58,900
+successful implantation, the uterus should undergo
+
+94
+00:06:58,900 --> 00:07:02,660
+structural and functional remodeling يعني معناها
+
+95
+00:07:02,660 --> 00:07:07,020
+إنه لازم أنا أهيأ الرحم للتغيرات الفيسيولوجية
+
+96
+00:07:07,020 --> 00:07:11,710
+والوظيفية المطلوبةالتمدد مثلًا، تسارع عملية انقصام
+
+97
+00:07:11,710 --> 00:07:15,410
+الخلايا، زيادة الـBlood supply، زيادة مستوى
+
+98
+00:07:15,410 --> 00:07:18,650
+الهرمونات المعينة زي الـ Progesterone عشان كده
+
+99
+00:07:18,650 --> 00:07:23,310
+حكينا بعد الـ IG بعد عملية الـ Improtransfer في
+
+100
+00:07:23,310 --> 00:07:26,530
+الـ Agonist و الـ Antagonist الزوجة أو المرأة
+
+101
+00:07:26,530 --> 00:07:30,010
+تُعطى Progesterone عن طريق الـ cervical من أجل
+
+102
+00:07:30,010 --> 00:07:35,070
+تحفيز زيادة أو من أجل تحفيز وزيادة معدل نمو
+
+103
+00:07:35,070 --> 00:07:39,430
+الخلايا المبطنة للرحمومن أجل تثبيت الجنين ومن أجل
+
+104
+00:07:39,430 --> 00:07:43,850
+المساعدة في زيادة فرصة الـ implantation أثناء
+
+105
+00:07:43,850 --> 00:07:48,790
+عملية تاريجية الأجنة الملقحة أو التي خلقت ..
+
+106
+00:07:48,790 --> 00:07:51,610
+خلّينا نسميها .. أو التي نتجت من التلقيح الصناعي
+
+107
+00:07:51,610 --> 00:07:55,970
+في المختبر الاستروجين و البروجسترون هم الهرمون
+
+108
+00:07:55,970 --> 00:08:02,990
+المعروف هذا الهرمون سيفعلpoint and rule in this
+
+109
+00:08:02,990 --> 00:08:07,090
+step or in this function وهي structural and
+
+110
+00:08:07,090 --> 00:08:11,210
+functional remodeling of uterus فبالتالي عند
+
+111
+00:08:11,210 --> 00:08:14,170
+الاستروجين و البروجيسترون هما الأشهر الغرمونات
+
+112
+00:08:14,170 --> 00:08:19,330
+اللتي تلعب دورة مهمة و أساسيا و فعالة لعملية تهيئ
+
+113
+00:08:19,330 --> 00:08:24,550
+الرحم لاستقبال الجنين البروجيسترون أيضا بيلعب دورة
+
+114
+00:08:24,550 --> 00:08:27,950
+رئيسية في عملية إنجاح ال implantation من خلال
+
+115
+00:08:27,950 --> 00:08:33,730
+تدعيم وزيادة معدل نمو الأجنةبالإضافة إلى زيادة أو
+
+116
+00:08:33,730 --> 00:08:38,370
+تدايم نمو وتطور الجنين لكي يصل إلى المرحلة
+
+117
+00:08:38,370 --> 00:08:42,050
+المقلوبة التي تساهم في عملية ال implantation في ال
+
+118
+00:08:42,050 --> 00:08:44,550
+follicular phase is under influence of rising
+
+119
+00:08:44,550 --> 00:08:48,010
+estrogen level due to growing ovarian follicle إذا
+
+120
+00:08:48,010 --> 00:08:51,450
+بنرجع بالذاكرة لل chapter 2 قلنا فيه عندى .. أو ال
+
+121
+00:08:51,450 --> 00:08:53,710
+chapter 2 فيه عندى ال follicular phase و ال
+
+122
+00:08:53,710 --> 00:08:56,430
+follicular phase هو عبارة عن الطور اللي تبدأ
+
+123
+00:08:56,430 --> 00:09:00,670
+البويضة في النضوجفلوكيلة بالنضوج يعني البويضة
+
+124
+00:09:00,670 --> 00:09:04,910
+بالنضوج بداخلها نضوج البويضة معناه إفراز هرمون
+
+125
+00:09:04,910 --> 00:09:10,190
+الاستروجين الذي يرسل إشارة إلى الرحم و لخلايا
+
+126
+00:09:10,190 --> 00:09:12,790
+الرحم أي الخلايا المبطلة للرحم اللي سميتها
+
+127
+00:09:12,790 --> 00:09:17,910
+endomateria من أجل البدء في الإنقسام والتضاعف
+
+128
+00:09:17,910 --> 00:09:24,430
+لتهيئة الرحم لاستقبال بويضة مخصبة إن حدث التخسيب
+
+129
+00:09:24,430 --> 00:09:29,230
+لذلك يقول إن الاستروجينأيضًا دورهم خلال
+
+130
+00:09:29,230 --> 00:09:34,150
+الـFollicular phase لتو Proliferation of
+
+131
+00:09:34,150 --> 00:09:38,230
+epithelium stroma and vascular endothelium to
+
+132
+00:09:38,230 --> 00:09:42,800
+cause regeneration of the endomaterialعرفت ايه وش
+
+133
+00:09:42,800 --> 00:09:46,720
+وظيفة الاستروجين و اين يفرز الاستروجين اعمل
+
+134
+00:09:46,720 --> 00:09:50,260
+flashback لل chapter التاني او التالت هنعرف ان
+
+135
+00:09:50,260 --> 00:09:54,460
+الاستروجين يفرز من البويضة او من ال filicular التي
+
+136
+00:09:54,460 --> 00:09:59,020
+تبدأ بالنضوج و كل ما زاد عدد البويضات الناضجة زاد
+
+137
+00:09:59,020 --> 00:10:02,640
+مستوى الاستروجين علشان كده قلنا ان الاستروجين
+
+138
+00:10:02,640 --> 00:10:06,780
+يعتبر احد ال indicator التي تستخدم للتعرف على عدد
+
+139
+00:10:06,780 --> 00:10:11,630
+البويضات التي قد تنضج مستقبلاما هو وظيفته في عملية
+
+140
+00:10:11,630 --> 00:10:15,290
+الـ Implantation؟ إنه يرسل إسشارة إلى الـUterus
+
+141
+00:10:15,290 --> 00:10:19,930
+إنه تبدأ خلايا بطاقة الرحم تنمو وتضاعف وتتكثر من
+
+142
+00:10:19,930 --> 00:10:25,430
+أجل تهيئ الرحم لإستقبال جنين جديد أو بوادة مخصرة
+
+143
+00:10:25,430 --> 00:10:33,530
+الـ Estrogen can induce Uterine طبعا ال Estrogen
+
+144
+00:10:33,530 --> 00:10:38,330
+أيضا بلعب دور في زيادة قابلية الرحم إن يستقبل هذه
+
+145
+00:10:38,330 --> 00:10:45,570
+البوادة من خلالحاكنها في مصابة من خلال زيادة معدل
+
+146
+00:10:45,570 --> 00:10:49,750
+مضوج الخلايا زيادة blood supply remaining open for
+
+147
+00:10:49,750 --> 00:10:54,730
+extended period at lower estrogen level يعني مش بس
+
+148
+00:10:54,730 --> 00:10:59,430
+انه بيزيد معدل استقبال او معدل نموب و تكاثر
+
+149
+00:10:59,430 --> 00:11:03,390
+الخلايا لأ انه بيعمل extension لعدد الايام اللتي
+
+150
+00:11:03,390 --> 00:11:07,450
+تسمحلبيطانة الرحم باستقبال الجنين اللي احنا قلناها
+
+151
+00:11:07,450 --> 00:11:11,890
+اربع أيام اضافية رغم انه فيه ست أيام اربع ايام
+
+152
+00:11:11,890 --> 00:11:14,370
+اضافية بفعل ال E2
+
+153
+00:11:16,840 --> 00:11:22,620
+أيضًا بالنسبة للأستروجين level is improved when
+
+154
+00:11:22,620 --> 00:11:24,860
+estrogen levels are decreased during pre
+
+155
+00:11:24,860 --> 00:11:27,960
+-implantation period and patients undergo in vitro
+
+156
+00:11:27,960 --> 00:11:32,480
+fertilization مهم جدًا من أجل زيادة وتحسين قدرة
+
+157
+00:11:32,480 --> 00:11:36,820
+الرحم على استقبال البويضة المخصبة لإيصال reduction
+
+158
+00:11:36,820 --> 00:11:41,180
+للأستروجين مايعني reduction للأستروجين؟ معنى
+
+159
+00:11:41,180 --> 00:11:44,200
+reduction للأستروجين يعني مستوى الأستروجين يقل
+
+160
+00:11:44,410 --> 00:11:50,090
+معناه الجسم بيفهم تلقائيا ان الفوليكلر انفجرت وصار
+
+161
+00:11:50,090 --> 00:11:54,530
+ovulation يعني البويضة قد تكونقُصّبت فبالتالي
+
+162
+00:11:54,530 --> 00:11:57,190
+عملية الـFollicular phase وعملية الـ ovulation
+
+163
+00:11:57,190 --> 00:12:01,410
+انتهت منها انتهى الجسم منها يعني بتبدأ بمرحلة
+
+164
+00:12:01,410 --> 00:12:05,170
+جديدة وهي استقبال الجنين تحت مصطلح implantation
+
+165
+00:12:05,170 --> 00:12:08,310
+فبالتالي الاستروجين لازم يجل في هذه الفترة وإلا
+
+166
+00:12:08,310 --> 00:12:13,670
+إذا دلوا مرتفع معناه لسه ما صار في عندي الوصول
+
+167
+00:12:13,670 --> 00:12:16,710
+لدرجة النضوج البويضة معناه ما صار في عندي
+
+168
+00:12:16,710 --> 00:12:28,610
+ovulation لأ بالراحةالتي كانت
+
+169
+00:12:28,610 --> 00:12:34,070
+مفروض تكون صارها operation حاليا الـ early embryo
+
+170
+00:12:34,070 --> 00:12:38,430
+entered the uterine cavity as morela and become 32
+
+171
+00:12:38,430 --> 00:12:43,810
+to 265
+
+172
+00:12:43,810 --> 00:12:48,250
+65 cell blastocyst before implantation بمعنى آخرإن
+
+173
+00:12:48,250 --> 00:12:53,170
+الـ embryo ممكن يصل و يدخل تجويف الرحم يا إما على
+
+174
+00:12:53,170 --> 00:12:57,970
+شكل موريلا أو على شكل بلاستوست عدد خليها تصل إلى
+
+175
+00:12:57,970 --> 00:13:06,510
+2256 خلية موريلا أو بلاستوست والأكثر بلاستوست
+
+176
+00:13:06,510 --> 00:13:09,230
+Implantation beginning with the loss of zona
+
+177
+00:13:09,230 --> 00:13:12,750
+pellucida none of hatching as we know about one to
+
+178
+00:13:12,750 --> 00:13:16,290
+three day after موريلا entered the uterineCavity
+
+179
+00:13:16,290 --> 00:13:19,490
+in the preparation of attachment يعني عملية ال
+
+180
+00:13:19,490 --> 00:13:23,850
+implantation تبدأ بدخول الجنين في مرحلة الموريلا
+
+181
+00:13:23,850 --> 00:13:32,650
+إلى ال cavity الخاص برحم السيدة ثم تبدأ ال zona
+
+182
+00:13:32,650 --> 00:13:39,310
+pellucida باتهتك أو انقسم أو التقشر أو الإزالةهذا
+
+183
+00:13:39,310 --> 00:13:43,670
+تقريبا بياخد يوم إلى تلت أيام بعد دخول الموريلا
+
+184
+00:13:43,670 --> 00:13:48,250
+الوريتان كافيتي بعد كده بتبدأ عملية ال attachment
+
+185
+00:13:48,250 --> 00:13:52,190
+مع ال endomateria يعني تلت نقاط أساسية دخول
+
+186
+00:13:52,190 --> 00:13:58,930
+الموريلا او ال embryo از موريلا face لتجويف الرحم
+
+187
+00:13:58,930 --> 00:14:03,570
+ازالة وتهتك ال zona pellucida والبدء في عملية ال
+
+188
+00:14:03,570 --> 00:14:06,450
+attachment مع ال endomateriaعشان كده قسموا الـ
+
+189
+00:14:06,450 --> 00:14:09,950
+Implantation إلى تلت مقاطع أو تلت أطوار الطور
+
+190
+00:14:09,950 --> 00:14:13,690
+الأول بيسموه Opposition و الطور التاني بيسموه
+
+191
+00:14:13,690 --> 00:14:16,830
+Adhesion و الطور التالت بيسموه Invasion ال
+
+192
+00:14:16,830 --> 00:14:19,890
+Opposition بيصير فيه عند Plastocyst contact the
+
+193
+00:14:19,890 --> 00:14:22,290
+implantation site of the endomaterium يعني الـ
+
+194
+00:14:22,290 --> 00:14:25,290
+Plastocyst بتتصل بالمكات اللي المفروض بيصير فيه
+
+195
+00:14:25,290 --> 00:14:28,010
+Implantation بيسموه Opposition بعدين ال Adhesion
+
+196
+00:14:28,010 --> 00:14:33,480
+إن الـTrophoplast cellof the plastocyst تتصل مع
+
+197
+00:14:33,480 --> 00:14:36,880
+الـ endomaterium بعدين بيصير عندي invasion وهي
+
+198
+00:14:36,880 --> 00:14:41,040
+عبارة عن الانغماس أو الانغراس ان البلاستوست جميع
+
+199
+00:14:41,040 --> 00:14:45,500
+خلاياها تبدأ تتشابك مع ال endomaterium وتصبح جزء
+
+200
+00:14:45,500 --> 00:14:48,980
+لا يتجزأ منها هل بنسميها invasion انغراس
+
+201
+00:14:48,980 --> 00:14:50,820
+opposition
+
+202
+00:14:52,700 --> 00:14:55,160
+and adhesion implantation beginning with the
+
+203
+00:14:55,160 --> 00:14:57,900
+apposition of the blastocyst at the uterine and
+
+204
+00:14:57,900 --> 00:15:01,040
+epithelium generally about two to four days after
+
+205
+00:15:01,040 --> 00:15:04,920
+Morella entered the uterine cavity يعني بيقوللي ان
+
+206
+00:15:04,920 --> 00:15:08,220
+ال opposition و ال adhesion الخاصة بال
+
+207
+00:15:08,220 --> 00:15:12,600
+implantation على أساس أنهم أول حدثين بتبدأ من
+
+208
+00:15:12,600 --> 00:15:16,080
+اليوم التاني إلى اليوم الرابع بعد يعني عد يومين
+
+209
+00:15:16,080 --> 00:15:20,840
+إلى أربع أيام بعد دخول الموريلا إلى تجوف الرحمالـ
+
+210
+00:15:20,840 --> 00:15:24,700
+Implantation is considered العلماء صنفوا الـ
+
+211
+00:15:24,700 --> 00:15:30,040
+Implantation على إنها ظاهرة تسمى Pro-inflammatory
+
+212
+00:15:30,040 --> 00:15:33,870
+reactionطب ليه سموها بهذا الشكل؟ لإنه بيصير عندي
+
+213
+00:15:33,870 --> 00:15:39,090
+vasovascular permeability is marked increased at
+
+214
+00:15:39,090 --> 00:15:42,830
+the attachment site mediated by cyclooxygenase
+
+215
+00:15:42,830 --> 00:15:46,090
+derivative prostaglandin لإنه بيصير عندي شغلة شغل
+
+216
+00:15:46,090 --> 00:15:49,670
+الأولى زيادة النفازية الخاصة بالأواع الدموية مما
+
+217
+00:15:49,670 --> 00:15:54,170
+يؤدي إلى زيادة ضفق الدم للمكان الذي انغرص فيه
+
+218
+00:15:54,170 --> 00:15:58,830
+الجنين الشغلة التانية إفراز بعض المكونات الأساسية
+
+219
+00:15:58,830 --> 00:16:02,750
+التي تلعب دور كبير جداالتي تعمل على زيادة الضفف
+
+220
+00:16:02,750 --> 00:16:05,550
+قدامه و زيادة الدورة الدموية زي ال prostaglandin
+
+221
+00:16:05,550 --> 00:16:10,010
+اللي يسمونه coax prostaglandin او cyclooxygenase
+
+222
+00:16:12,810 --> 00:16:15,850
+Prostaglandin E2 هذا الكلام أخدناه تقريبا في
+
+223
+00:16:15,850 --> 00:16:19,710
+الشبتر الأول والشبتر التاني عرّجنا عليه بشكل بسيط
+
+224
+00:16:19,710 --> 00:16:23,350
+انه يقول برستاجلاندين E2 is increased in the
+
+225
+00:16:23,350 --> 00:16:27,310
+luminal epithelium and the underlying stroma at
+
+226
+00:16:27,310 --> 00:16:30,230
+the human implantation site يعني بيبدأ يزيد في
+
+227
+00:16:30,230 --> 00:16:33,890
+المنطقة اللي صار فيها implantation those indicate
+
+228
+00:16:33,890 --> 00:16:36,770
+its role in the attached and localized
+
+229
+00:16:36,770 --> 00:16:40,520
+endomaterium vascular permeabilityيعني
+
+230
+00:16:40,520 --> 00:16:45,340
+البروستاجلاندين E2 أول زياداته تكمن في المنطقة
+
+231
+00:16:45,340 --> 00:16:48,600
+اللي صار فيها attachment وإن البلاستوست عملت
+
+232
+00:16:48,600 --> 00:16:52,420
+attachment مع الـendomaterium يبدأ البروستاجلاندين
+
+233
+00:16:52,420 --> 00:16:56,420
+بالانفراز والخروج في هذه المنطقة طب إيش وظيفته؟
+
+234
+00:16:56,420 --> 00:17:00,140
+وظيفته بشكل أساسي Indicating its role in the
+
+235
+00:17:00,140 --> 00:17:03,340
+attachment and localized endomaterium vascular
+
+236
+00:17:03,340 --> 00:17:07,900
+permeability بحدد مكان ال attachment ما بين
+
+237
+00:17:07,900 --> 00:17:11,880
+البلاستوستوالـ endomateria مما يؤدي إلى زيادة
+
+238
+00:17:11,880 --> 00:17:15,960
+النفاذية الدموية لهذه المنطقة يعني زيادة الدور
+
+239
+00:17:15,960 --> 00:17:18,600
+الدموية وضخ الدم في هذه المنطقة اللي صار فيها
+
+240
+00:17:18,600 --> 00:17:23,400
+attachment during a position process, the placenta
+
+241
+00:17:23,400 --> 00:17:27,480
+differs into inner cell embryo and trophoectoderm
+
+242
+00:17:27,480 --> 00:17:30,770
+placentaخلال هذه العملية، وهي الخطوة الأولى من
+
+243
+00:17:30,770 --> 00:17:34,370
+عملية الـ Implantation لـ Plastocyst بتم فيها
+
+244
+00:17:34,370 --> 00:17:37,730
+عملية التمايز إلى two parts ال part الداخل اللي
+
+245
+00:17:37,730 --> 00:17:40,750
+بيسميها inner cell mass وهي عبارة عن إمبريو وال
+
+246
+00:17:40,750 --> 00:17:44,250
+part الخارجي وهي trophoectoderm اللي بيسميها
+
+247
+00:17:44,250 --> 00:17:48,770
+Placenta اللي بتكوّل لـ Placenta فيما بعدطبعا بعد
+
+248
+00:17:48,770 --> 00:17:52,830
+الحدثان الأول ال opposition بصير الحدث تاني وهو ال
+
+249
+00:17:52,830 --> 00:17:56,630
+adhesion stage و ال adhesion stage في الغالب in
+
+250
+00:17:56,630 --> 00:17:59,270
+which the association of trophoplast and the
+
+251
+00:17:59,270 --> 00:18:02,430
+luminal epithelia is strong enough to resist
+
+252
+00:18:02,430 --> 00:18:07,610
+delocalization of blastocyst by flushing the
+
+253
+00:18:07,610 --> 00:18:11,790
+uterine lumina بمعنى آخر أن هذا ال stage اللي سمته
+
+254
+00:18:11,790 --> 00:18:16,830
+adhesion مهم جدا لأنه بيلعب دور كبير جدا في تثبيت
+
+255
+00:18:17,360 --> 00:18:21,300
+الـ embryo في هذا المكان ومنع ال embryo من عملية
+
+256
+00:18:21,300 --> 00:18:24,760
+تغيير مكان يعني بيخلّيه resistant for this
+
+257
+00:18:24,760 --> 00:18:28,700
+location ما بيخلّيه يغير مكانه لأنه إذا صار
+
+258
+00:18:28,700 --> 00:18:31,760
+adhesion معناه الخطوة التانية ال invasion مهمة جدا
+
+259
+00:18:31,760 --> 00:18:37,040
+حتصير بدون adhesion معناه مافي عندي invasion طبعا
+
+260
+00:18:37,040 --> 00:18:41,380
+هذا ال stage اللي سمته adhesion بياخد ما يقارب من
+
+261
+00:18:41,380 --> 00:18:48,260
+20 إلى 21 يومومهم جدا في زيادة استمرارية تضافق
+
+262
+00:18:48,260 --> 00:18:51,720
+الدم إلى المكان اللي صار فيه attachment بعدين
+
+263
+00:18:51,720 --> 00:18:54,860
+بييجي بعد ال adhesion مرحلة أخرى وهي ال invasion
+
+264
+00:18:54,860 --> 00:19:00,340
+التي يتم من خلالها غوص ال embryo أو plasticist
+
+265
+00:19:00,340 --> 00:19:04,580
+بشكل شبه كامل داخل ال endometeria وتثبيتها بشكل
+
+266
+00:19:04,580 --> 00:19:09,540
+كبير جدا والبداية في تكوين البلسنتة
+
+267
+00:19:12,110 --> 00:19:17,450
+هذا بالنسبة إلى مراحل عملية الـ Implantation دعونا
+
+268
+00:19:17,450 --> 00:19:20,850
+ننتقل إلى موضوع جديد وهو الـ Embryo Transfer لم
+
+269
+00:19:20,850 --> 00:19:24,650
+أكن مسموح أن أعمل Embryo Transfer يعني 3 Embryo
+
+270
+00:19:24,650 --> 00:19:28,230
+بعد الحقن الميجاري ولا 2 ولا 4 ولا 5 في الغالب
+
+271
+00:19:28,230 --> 00:19:34,010
+معظم المراكز ثبتت إن أنا أعمل Transfer لتنوء 2
+
+272
+00:19:34,010 --> 00:19:37,370
+Embryo ولكن يعتمد هذا على الحالة ممكن أعمل
+
+273
+00:19:37,370 --> 00:19:42,150
+Transfer ل 1 Embryo أو 3 Embryo مع بعضفي الدول
+
+274
+00:19:42,150 --> 00:19:44,750
+البرا القانون واحد embryo مافيش اكتر و كده بعض
+
+275
+00:19:44,750 --> 00:19:49,370
+الحالات بيرجع اتنين بموافق خطية من المريض ولكن
+
+276
+00:19:49,370 --> 00:19:53,890
+قانونا one embryo embryo transfer can be performed
+
+277
+00:19:53,890 --> 00:19:57,990
+in the day three after cleavage or after
+
+278
+00:19:57,990 --> 00:20:03,130
+fertilization or day five in the plastocyst stage
+
+279
+00:20:03,130 --> 00:20:07,070
+after fertilization و هذا او after egg collection
+
+280
+00:20:07,070 --> 00:20:09,950
+and fertilizationيعني أنا مسموح ليه ك
+
+281
+00:20:09,950 --> 00:20:14,190
+emperiologist أرجع الأجنة في اليوم التاني أو اليوم
+
+282
+00:20:14,190 --> 00:20:18,910
+الخامس أو اليوم السادس طبعاً لها قوانين معينة لها
+
+283
+00:20:18,910 --> 00:20:22,150
+ضوابط معينة ولكن in general اليوم التالت بعض
+
+284
+00:20:22,150 --> 00:20:25,970
+الأحيان اليوم الخامسالـ United States على سبيل
+
+285
+00:20:25,970 --> 00:20:29,790
+المثال في protocol أنه أنا ما برجّع الجنين إلا في
+
+286
+00:20:29,790 --> 00:20:32,730
+اليوم الخامس يعني لما نصل لمرحلة ال plus و sixth
+
+287
+00:20:32,730 --> 00:20:38,250
+stage في اليوم التالت مسموح لأرجع فقط ال embryo
+
+288
+00:20:38,250 --> 00:20:41,910
+اللي هو عبارة عن good quality embryo or generally
+
+289
+00:20:41,910 --> 00:20:45,810
+between six to eight cells شو يعني good quality؟
+
+290
+00:20:45,810 --> 00:20:50,350
+هنعرفها كمان شوية ولكن بقول في اليوم التالت الجنين
+
+291
+00:20:50,350 --> 00:20:54,720
+دائما بكون من ست خلايا لتمان خلاياطالما الجنين وصل
+
+292
+00:20:54,720 --> 00:20:59,900
+ل 6 خلايا أو 8 خلايا مسموح لأرجع رجع جنين إلى رحم
+
+293
+00:20:59,900 --> 00:21:03,700
+السيدة أو اتنين أو تلاتة بناء على اعتبارات معينة
+
+294
+00:21:03,700 --> 00:21:08,830
+ولكن بعض المراكز ثبتت على اليوم الخامسالفرصة
+
+295
+00:21:08,830 --> 00:21:13,430
+للمنتظر حتى اليوم الخامس هي أنها تقدم وقت أضافي
+
+296
+00:21:13,430 --> 00:21:18,410
+لتختار البرنامج بقيمة أفضل لأن فقط 50%-60% من
+
+297
+00:21:18,410 --> 00:21:20,850
+البرنامج يمتلك القدرة على التطور إلى البرنامج
+
+298
+00:21:20,850 --> 00:21:25,450
+البلاستيكي ومن ثم أقل من البرنامج مستحيل للتبريد
+
+299
+00:21:25,450 --> 00:21:29,450
+والتحريك ليه سببته على اليوم الخامس؟ بقولك لأن
+
+300
+00:21:29,450 --> 00:21:32,830
+التأخر في عملية إرجاع الأجنب وبقاء الجنين في
+
+301
+00:21:32,830 --> 00:21:37,460
+المختبرفي الظروف المناسبة داخل ال incubator يسمح
+
+302
+00:21:37,460 --> 00:21:43,100
+للجنين بالنمو والتضاعف بشكل مناسب بشكل ملحوظ بشكل
+
+303
+00:21:43,100 --> 00:21:49,480
+يعطي له أفضلية للبقاء إن تم ترجعه أضيف إلى ذلك أن
+
+304
+00:21:49,480 --> 00:21:54,620
+تأخير عملية الترجع تعطيني information أكتر عن كيف
+
+305
+00:21:55,020 --> 00:21:58,520
+يتحرك هذا الجنين أو كيف ينمو هذا الجنين أو كيف
+
+306
+00:21:58,520 --> 00:22:03,840
+تنقسم خلايا هذا الجنين إضافة إلى أنها تسمح لي بعمل
+
+307
+00:22:03,840 --> 00:22:08,060
+فحوصات المطلوبة من أجل اختيار أفضل جنين من أجل
+
+308
+00:22:08,060 --> 00:22:13,100
+ارجع من أجل ارجع أيضا ان في بعض الأحيان بكون عندى
+
+309
+00:22:13,100 --> 00:22:18,310
+عشر أجنةفأنا بلجأ إلى تخزين بعض الأجنة مش منطق
+
+310
+00:22:18,310 --> 00:22:22,090
+أرجع عشر أجنة برجع تلاتة اتنين طب و الباقي أرميهم
+
+311
+00:22:22,090 --> 00:22:25,690
+أعملهم إتلاف أعملهم removing لأ بعمله بحاجة اسمها
+
+312
+00:22:25,690 --> 00:22:31,510
+freezing أو cryopreservation الحفظ بالتبريد طب أنا
+
+313
+00:22:31,510 --> 00:22:34,850
+مين أفضل أعمله cryopreservation و freezing و هو في
+
+314
+00:22:34,850 --> 00:22:39,270
+اليوم التاني أو التالت أو بعد خمس أيام كل ما زادت
+
+315
+00:22:39,270 --> 00:22:43,540
+فترة الانتظار كل ما كان نتيجة ال freezing أفضللأن
+
+316
+00:22:43,540 --> 00:22:48,380
+بكون الجنين كده خلايا شبه استقارات فبالتالي إذا
+
+317
+00:22:48,380 --> 00:22:51,140
+أنا عملت freezing في اليوم الخامس أو اليوم السادس
+
+318
+00:22:51,140 --> 00:22:54,440
+أفضل من إني أعمل freezing للأجنة أو للبواية ..
+
+319
+00:22:54,440 --> 00:22:58,460
+للأجنة عفوا في اليوم التاني أو التالت لأنه لسه ما
+
+320
+00:22:58,460 --> 00:23:03,960
+اتزالت في مرحلة الإنقاذ The recommended number of
+
+321
+00:23:03,960 --> 00:23:07,580
+embryo to transfer is determined by women age and
+
+322
+00:23:07,580 --> 00:23:10,930
+timing of the embryo transfer يعني أنا ..جدش بدأ
+
+323
+00:23:10,930 --> 00:23:13,790
+أرجع embryo هذا يعتمد على سن المرأة والله إذا كانت
+
+324
+00:23:13,790 --> 00:23:17,990
+المرأة كبيرة في العمر يعني بعد الأربعين فرصة
+
+325
+00:23:17,990 --> 00:23:22,090
+الإنجاب إلى كل ما زاد العمر تقل فبالتالي ممكن ألجأ
+
+326
+00:23:22,090 --> 00:23:27,110
+إلى زيادة عدد ال embryo المرجع السيدة لسه شابة في
+
+327
+00:23:27,110 --> 00:23:31,680
+بداية العشريناتمش منطقي أنا لسه عنده فترة زمانية
+
+328
+00:23:31,680 --> 00:23:34,060
+طويلة لإنجاب مرة و اتنين و تلاتة و أربع مش منطقي
+
+329
+00:23:34,060 --> 00:23:37,180
+في المرة الأولى أروح و أرجع لتلاتة embryo لأ واحد
+
+330
+00:23:37,180 --> 00:23:41,140
+اتنين maximum فبالتالي اللي بحكم هذه العملية عمر
+
+331
+00:23:41,140 --> 00:23:45,940
+السيدة و equality of embryo يعني أنه على سبيل
+
+332
+00:23:45,940 --> 00:23:50,460
+المثال عندي عشرة بويضات لقحت العشر بويضات أندي عشر
+
+333
+00:23:50,460 --> 00:23:54,360
+أجنة في العشر أجنة ما لجيت إلا اتنين embryo هم
+
+334
+00:23:54,360 --> 00:23:58,180
+اللي انقسموا و هم أفضل embryo اللي باجي مش كويسين
+
+335
+00:23:58,180 --> 00:24:03,350
+ده الفكرةمنطق أرجع للإثنين و أخلصنا من هذه القصة
+
+336
+00:24:03,350 --> 00:24:06,550
+لأنه ليس منطق أرجع واحد و بعدها أذهب و أعمله
+
+337
+00:24:06,550 --> 00:24:11,350
+freezing لأن تمانية الباقين ما انقسموا فبالتالي as
+
+338
+00:24:11,350 --> 00:24:16,270
+one chance أرجع الإثنين إحتياطا إثنين ناموا و
+
+339
+00:24:16,270 --> 00:24:19,010
+أصبحوا in block و أنا بيها واحد اه و واحد لأ كده
+
+340
+00:24:19,010 --> 00:24:24,350
+انا بكون عندي probability أو chance 50% a serum
+
+341
+00:24:24,350 --> 00:24:29,610
+pregnancy test is performed11 day after cleavage
+
+342
+00:24:29,610 --> 00:24:34,510
+or embryo transfer 9 day after blastocyst transfer
+
+343
+00:24:34,510 --> 00:24:40,950
+انا عملت نقل للاجنة ممكن اعمل فحص ال beta sc و او
+
+344
+00:24:40,950 --> 00:24:45,490
+فحص الحمل في اليوم رقم 11 من نقل ال embryo او في
+
+345
+00:24:45,490 --> 00:24:49,790
+اليوم رقم 9 من نقل ال blastocyst و معظمهم بيعملوا
+
+346
+00:24:49,790 --> 00:24:53,770
+في اليوم رقم 9 معظم في اليوم رقم 9 نادر جدا ما
+
+347
+00:24:53,770 --> 00:24:58,240
+يعملوا في اليوم رقم 14 معظم بيعملوا في اليومرقم 9
+
+348
+00:24:58,240 --> 00:25:01,580
+يعني بمعنى أخر في واحد الشهر صار embryo transfer
+
+349
+00:25:01,580 --> 00:25:05,940
+في عشر الشهر بتيجي بتعمل أو تسعة الشهر بتيجي بتعمل
+
+350
+00:25:05,940 --> 00:25:10,400
+ال beta at CG عشان تاخد احتياطاتها أيضا طبعا
+
+351
+00:25:10,400 --> 00:25:14,000
+بيعملوا من الدم مش من اليوريم خصوصا للسيدات اللي
+
+352
+00:25:14,000 --> 00:25:19,640
+خضعوا ال IV جدول بوضحلي عدد ال embryo المفضل
+
+353
+00:25:19,640 --> 00:25:24,940
+ارجعهابناء على العمر إذا كانت السيدة أقل من 35
+
+354
+00:25:24,940 --> 00:25:30,200
+برجع one embryo the best if no hcg embryo present
+
+355
+00:25:30,200 --> 00:25:33,620
+إذا مافيش إيش يعني hg high quality يعني إذا فيه
+
+356
+00:25:33,620 --> 00:25:36,220
+أنا عندي embryo high quality برجع واحد مافي عندي
+
+357
+00:25:36,220 --> 00:25:39,440
+high quality برجع اتنين هذه للسيدة اللي عمرها 35
+
+358
+00:25:39,440 --> 00:25:44,280
+وأقل من 35 ل 37 إذا في عندي high quality برجع واحد
+
+359
+00:25:44,280 --> 00:25:48,800
+مافيه برجع اتنين من 38 ل 40 مافي عندي high quality
+
+360
+00:25:48,800 --> 00:25:54,320
+هرجع اتنينhigh quality embryo ولكن عمرها 38 إذا
+
+361
+00:25:54,320 --> 00:25:59,120
+فرصة الإنجاب مستقبلا بتقلب ومابدأ أخضعها لل
+
+362
+00:25:59,120 --> 00:26:03,040
+ovarian stimulation أكتر من مرة فبرجع two embryo
+
+363
+00:26:03,040 --> 00:26:07,200
+علشان أزيد فرصة نجاح ال IVF والله مافي عندي high
+
+364
+00:26:07,200 --> 00:26:12,660
+quality embryo برجع تلاتة عندي عدد ال age أقل أربع
+
+365
+00:26:12,660 --> 00:26:15,780
+أربعين وفوق يعني أكبر من أربعين يعني قريبا من ال
+
+366
+00:26:15,780 --> 00:26:20,030
+monopiosبرجّه خمسة embryo رغم أنه موجود في high
+
+367
+00:26:20,030 --> 00:26:23,250
+quality embryo مافي عندي high quality أيضا برجّه
+
+368
+00:26:23,250 --> 00:26:27,230
+خمسة embryo شو يعني high quality؟ ال high quality
+
+369
+00:26:27,230 --> 00:26:33,350
+embryo يعني embryo يحتوي على ست خلايا بلاستوميرة
+
+370
+00:26:33,350 --> 00:26:38,490
+أو أكبر ست خلايا بلاستوميرة أو أكبر بمعنى أخر عدد
+
+371
+00:26:38,490 --> 00:26:44,530
+الأجنةالمرجعة تتناسب تناسبا ترضيا مع سن الزوجة أو
+
+372
+00:26:44,530 --> 00:26:52,010
+الأنفة كلما زاد سنها كلما زاد عدد الأجنة المرجعة
+
+373
+00:26:52,010 --> 00:26:59,310
+طبعا جدول آخر بوضّح لي شو يعني grade 1 و grade 2 و
+
+374
+00:26:59,310 --> 00:27:03,870
+grade 3 و grade 4 يعني شو يعني high quality embryo
+
+375
+00:27:03,870 --> 00:27:07,690
+grade 1 معناه الخلايا الـplastomeraالـ Plastomere
+
+376
+00:27:07,690 --> 00:27:11,610
+الموجودة داخل الـ embryo متساوية في الحجم و مافي
+
+377
+00:27:11,610 --> 00:27:15,970
+عنده fragmentation grade 2 متساوية في الحجم ولكن
+
+378
+00:27:15,970 --> 00:27:20,430
+في القليل من ال fragmentation grade 3 cell are
+
+379
+00:27:20,430 --> 00:27:24,990
+unequal in the size no fragmentation to moderate
+
+380
+00:27:24,990 --> 00:27:29,430
+fragmentation يعني مافي عنده تساوية في الحجم و
+
+381
+00:27:29,430 --> 00:27:35,190
+خلية عند مثلا في اليوم grade 3في اليوم التاني في
+
+382
+00:27:35,190 --> 00:27:37,150
+اليوم التاني المفروض يكون عندى أربعة خلايا لاجئت
+
+383
+00:27:37,150 --> 00:27:40,270
+تلت خلايا أكبر وخالية صغيرة مافي عندى تساوي في
+
+384
+00:27:40,270 --> 00:27:44,770
+الحجم فبسميها grade 3 وعندى ال fragmentation بدأ
+
+385
+00:27:44,770 --> 00:27:50,030
+يظهر moderate أما grade 4 هي عبارة عن ال cell are
+
+386
+00:27:50,030 --> 00:27:53,730
+of equal or unequal size fragmentation is moderate
+
+387
+00:27:53,730 --> 00:27:56,310
+to heavy في عندى fragmentation بشكل كبير جدا تاب
+
+388
+00:27:56,310 --> 00:28:01,570
+سؤالى متى بعمل evaluation أو grading لل embryo في
+
+389
+00:28:01,570 --> 00:28:04,710
+اليوم الأول من انقصاه؟يوم التاني وليوم التالت لأ
+
+390
+00:28:04,710 --> 00:28:09,710
+في يوم الترجيع بعمل عملية grading او evaluation او
+
+391
+00:28:09,710 --> 00:28:13,010
+ممكن ابدأ في اليوم التالت اليوم التالت اعمل
+
+392
+00:28:13,010 --> 00:28:16,510
+evaluation اليوم الرابع اليوم الخامس ويوم الترجيع
+
+393
+00:28:16,510 --> 00:28:19,550
+مهم جدا عشان اعرف والله هذا ال embryo رقم واحد
+
+394
+00:28:19,550 --> 00:28:23,410
+grade واحد رقم خمسة grade اتنين رقم عشرة grade
+
+395
+00:28:23,410 --> 00:28:27,790
+واحد فبرجع فقط ل grade واحد بين جثين high quality
+
+396
+00:28:27,790 --> 00:28:32,090
+يعني grade واحد معناها high quality وتتميز بوجود
+
+397
+00:28:33,010 --> 00:28:37,750
+تناسق وتساوي في حجم الخلايا الموجودة داخل الـ
+
+398
+00:28:37,750 --> 00:28:40,810
+Imperolizameta Plastomera بالاضافة إلى عدم وجود
+
+399
+00:28:40,810 --> 00:28:45,770
+fragment في الـCytoplasm كيف يتم عملية الإرجاع؟
+
+400
+00:28:45,770 --> 00:28:50,070
+صورة بتوضح معظم ال steps اللي احنا اتكلمنا عنها في
+
+401
+00:28:50,070 --> 00:28:53,940
+عملية الإجزينبدأ بالخطوة الأولى وهي عبارة عن
+
+402
+00:28:53,940 --> 00:28:57,340
+ovarian stimulation زوجة بتخضع إلى ال agonist أو
+
+403
+00:28:57,340 --> 00:29:00,520
+ال antagonist ovarian stimulation protocol سواء
+
+404
+00:29:00,520 --> 00:29:06,700
+كانت short أو long أو ultra short short long ultra
+
+405
+00:29:06,700 --> 00:29:14,620
+short protocol بعد كده المبيضة ببدأ البويضات
+
+406
+00:29:14,620 --> 00:29:17,520
+الفولك اللي بتنمو البويضات تنضج بصير عندي
+
+407
+00:29:17,520 --> 00:29:21,960
+aspiration for egg و اللي سميتها egg backupبعد كده
+
+408
+00:29:21,960 --> 00:29:25,060
+ال egg pick up بيسيلها عملية treatment عن طريق ال
+
+409
+00:29:25,060 --> 00:29:29,780
+denodation و خلافه في نفس اللحظة باجي بعمل semen
+
+410
+00:29:29,780 --> 00:29:36,360
+analysis للميل و semen preparation بعد كده بعمل
+
+411
+00:29:36,360 --> 00:29:40,140
+fertilization إما باستخدام ال IVF إنه بوايضة مع ال
+
+412
+00:29:40,140 --> 00:29:43,460
+sperm أو باستخدام ال eggs on درجة الحقن المجهري
+
+413
+00:29:43,460 --> 00:29:47,860
+بعد عملية ال fertilization تبدأ البوايضة بالانقسام
+
+414
+00:29:47,860 --> 00:29:55,160
+زي goatخليتين، أربع خلايا، ثم تمن خلايا وست وستاش
+
+415
+00:29:55,160 --> 00:29:59,220
+واتنين وتلاتين بعد كده لما تصل لمرحلة الـ Morella
+
+416
+00:29:59,220 --> 00:30:05,280
+أو الـ Plasticist باجي بعملية الإرجاع من خلال
+
+417
+00:30:05,280 --> 00:30:09,280
+مرحلة بنسميها Embryo Transfer وعملية الإرجاع لا
+
+418
+00:30:09,280 --> 00:30:13,940
+تحدث إلا للأجنة لأنها تعتبر grade one كfirst
+
+419
+00:30:13,940 --> 00:30:14,440
+chance
+
+420
+00:30:21,550 --> 00:30:24,790
+الأخير الموضوع اللي بنتكلم فيه هو الـ
+
+421
+00:30:24,790 --> 00:30:31,730
+cryopreservation كيف نقوم لعملية حفظ
+
+422
+00:30:31,730 --> 00:30:38,030
+البويضة أو حفظ الأجنة عندى خمس أجنة عمر
+
+423
+00:30:38,030 --> 00:30:40,950
+السيدة أقل من تلاتين سنة يعني لازم بناء على
+
+424
+00:30:40,950 --> 00:30:45,920
+القانون أرجع جنين واحد للباقى الأجنة أعملهمبعملهم
+
+425
+00:30:45,920 --> 00:30:49,760
+Cryopreservation شو يعني Cryopreservation؟ كيف
+
+426
+00:30:49,760 --> 00:30:54,600
+نقوم بعمل Cryopreservation؟ فعملية التقنيات
+
+427
+00:30:54,600 --> 00:30:59,920
+المساعدة على الإنجاب تعتبر أفضل التقنية .. تقنية
+
+428
+00:30:59,920 --> 00:31:03,120
+الـ Exit طبعا في الوضع الحالي أفضل التقنيات التي
+
+429
+00:31:03,120 --> 00:31:07,540
+تستخدم لحل مشكلة ال infertility عند الفيميل
+
+430
+00:31:07,540 --> 00:31:12,060
+بالإضافة إلى عملية حفظ ال fertility للمال والفيميل
+
+431
+00:31:12,060 --> 00:31:15,710
+كيف يعني حفظ ال fertility؟ يعنيفي ميل بدأت أتعرض
+
+432
+00:31:15,710 --> 00:31:20,130
+لراديو ثيرابي كيمو ثيرابي باجي بخليها تخضع ل
+
+433
+00:31:20,130 --> 00:31:24,690
+ovarian stimulation بجمع البويضات والبويضات بعملها
+
+434
+00:31:24,690 --> 00:31:32,330
+cryopreservation حفظ أو عندي ميل بده يعمل إجزي هو
+
+435
+00:31:32,330 --> 00:31:35,690
+و ال cabulist بتاعه بده يعمل إجزي مش مابقدر يجيب
+
+436
+00:31:35,690 --> 00:31:38,550
+عينة دائما مش دائما ال parameter بتاعة ال semen
+
+437
+00:31:38,550 --> 00:31:42,530
+fluid بتكون طبيعية فمرة من المرات جاب عينة لجناها
+
+438
+00:31:42,770 --> 00:31:46,530
+Full Normal خلّيني أسميها بهذا الشكل أو Normal
+
+439
+00:31:46,530 --> 00:31:50,290
+بالنسبة لـ 50% فبلجأ إنه أحفظ الـ spermatozoa عن
+
+440
+00:31:50,290 --> 00:31:54,830
+طريق الـ Cryopreservation حتى تتم عملية الـ XGB
+
+441
+00:31:54,830 --> 00:31:58,510
+نجح أول حاجة جاميط الـ Cryopreservation لما أقول
+
+442
+00:31:58,510 --> 00:32:01,590
+جاميط الـ Cryopreservation يعني عملية تخزين
+
+443
+00:32:01,590 --> 00:32:05,150
+الجاميطات الأنثوية متمثلة في البويضات أو الجاميطات
+
+444
+00:32:05,150 --> 00:32:08,870
+الذكرية متمثلة في الـ sperm ممكن أن أحفظهم ممكن
+
+445
+00:32:08,870 --> 00:32:14,130
+أحفظهم ممكن يكونواavailable ممكن يعطوا نتيجة في
+
+446
+00:32:14,130 --> 00:32:17,790
+مباعد صحيح ممكن يكونوا available ويعطوا نتيجة اذا
+
+447
+00:32:17,790 --> 00:32:22,650
+عملية الجامد crab reservation تعتبر عملية مهمة جدا
+
+448
+00:32:22,650 --> 00:32:27,870
+للحفاظ على ال fertility for male and female before
+
+449
+00:32:27,870 --> 00:32:31,910
+exposure and this is process of care before
+
+450
+00:32:31,910 --> 00:32:35,250
+exposure to the cytotoxic therapy or chemotherapy
+
+451
+00:32:36,060 --> 00:32:38,940
+ممكن أعمل جميط ممكن أعمل جميط cryopreservation
+
+452
+00:32:38,940 --> 00:32:42,600
+ممكن أعمل embryo ممكن أعمل embryo cryopreservation
+
+453
+00:32:42,600 --> 00:32:47,720
+طبعا هذه بتعطي قابلية للإنجاب في مبعد للمال
+
+454
+00:32:47,720 --> 00:32:52,880
+والفيميل The ability of Iglis Harol to act as a
+
+455
+00:32:52,880 --> 00:32:56,260
+cryoprotective agent during freezing and thawing
+
+456
+00:32:56,260 --> 00:33:01,420
+of spermatozoa was the fairest report in 190094
+
+457
+00:33:01,420 --> 00:33:05,520
+طبعاً أول ما تم استخدام الـ cryoprotective agent
+
+458
+00:33:05,520 --> 00:33:10,140
+التي تحمي الجميطات من عملية التكسر و الانهيار
+
+459
+00:33:10,140 --> 00:33:14,260
+استخدمه لـ glycerol كان هو أول cryoprotective
+
+460
+00:33:14,260 --> 00:33:20,160
+agent و تم استخدامه في عام 1949 و فيما بعد كان أول
+
+461
+00:33:20,160 --> 00:33:25,940
+طفل نتج من عملية جميط cryopreservation تم تسجيلها
+
+462
+00:33:25,940 --> 00:33:31,740
+في عام 1950وهو عبارة عن طفل أنجب بعد ما تم تلقيح
+
+463
+00:33:31,740 --> 00:33:35,820
+البوادة من cryopreservative او cryopreserved sperm
+
+464
+00:33:35,820 --> 00:33:43,400
+تم تخزينه استخدام ال cryopreservation survival
+
+465
+00:33:43,400 --> 00:33:46,820
+fertilization and fetal development followed
+
+466
+00:33:46,820 --> 00:33:50,340
+cryopreservation of unfertilized mouse or oocyte
+
+467
+00:33:50,340 --> 00:33:56,180
+using dimso were the first report in 1917 يعني
+
+468
+00:33:56,180 --> 00:34:00,850
+بمعنى أخربعد كده تم تطوير بعض الـ cryoprotective
+
+469
+00:34:00,850 --> 00:34:05,170
+agent بخلاف الجليسرول فاستخدموا الدمسو و الدمسو هي
+
+470
+00:34:05,170 --> 00:34:10,610
+عبارة عن مادة كيميائية إلى حد ما تستخدم as
+
+471
+00:34:10,610 --> 00:34:15,050
+cryopreservative agent زيها زي الجليسرول و تم
+
+472
+00:34:15,050 --> 00:34:19,630
+اعطاء نتائج جدا رائعة في عملية الـ
+
+473
+00:34:19,630 --> 00:34:22,590
+cryopreservation و الحفاظ على الجميطات من عملية
+
+474
+00:34:22,590 --> 00:34:26,350
+الانهيار والتكسفطيب سؤالي when the oocyte
+
+475
+00:34:26,350 --> 00:34:29,410
+fertilizing .. fertilizing كان okay متى انا ممكن
+
+476
+00:34:29,410 --> 00:34:35,290
+اعمل fertili .. متى ممكن اعمل ال freezing لل
+
+477
+00:34:35,290 --> 00:34:39,830
+oocyte تحت عنوان when the oocyte freezing كان okay
+
+478
+00:34:39,830 --> 00:34:45,090
+متى ممكن اعمل freezing لل oocyte طبعا في عندي اكثر
+
+479
+00:34:45,090 --> 00:34:49,250
+من حالة ممكن اعملها freezing طبعا women محتاجة
+
+480
+00:34:49,250 --> 00:34:52,090
+انها تعمل .. تاخد جرعة chemotherapy او
+
+481
+00:34:52,090 --> 00:34:56,040
+radiotherapyولكن عندها رغبة في الإنجاب فيما بعد
+
+482
+00:34:56,040 --> 00:34:59,940
+لأن سنها ما زال صغير تلاتين سنة مثلا أو أواخر
+
+483
+00:34:59,940 --> 00:35:03,580
+الأشرينات ولكن شقة الأقدار انها صار عندها cancer
+
+484
+00:35:03,580 --> 00:35:07,320
+راحت تعمل ريديو ثيرابي كيميو ثيرابي شرعات فبدها
+
+485
+00:35:07,320 --> 00:35:11,500
+تنجب فيما بعد فممكن نعملها oocyte freezing من خلال
+
+486
+00:35:11,500 --> 00:35:15,540
+إدخالها في برنامج ovarian stimulation وجمع أكبر
+
+487
+00:35:15,540 --> 00:35:19,840
+عدد من البويضات وتخزينها وبعد فترة زمنية من انتهاء
+
+488
+00:35:19,840 --> 00:35:23,460
+الحالة الموجودة حالياأو انتهاء جرعة الكيموثيرابي
+
+489
+00:35:23,460 --> 00:35:28,220
+ممكن تبدأ بعملية الـcycling الجديدة اللي لها من
+
+490
+00:35:28,220 --> 00:35:32,760
+خلال عملية الـthawing for oocyte freezing بعدين ال
+
+491
+00:35:32,760 --> 00:35:37,420
+fertilization بعض ال medication زي حكينا ال radio
+
+492
+00:35:37,420 --> 00:35:40,440
+therapy و الكيموثيرابي اللي ممكن تدمر ال fertility
+
+493
+00:35:40,440 --> 00:35:43,820
+الخاصة بالفيميل ال IgG freezing before treatment
+
+494
+00:35:43,820 --> 00:35:47,560
+maybe enable you to have biological children later
+
+495
+00:35:47,560 --> 00:35:51,900
+أكيدwomen undergoing in vitro fertilization when
+
+496
+00:35:51,900 --> 00:35:56,180
+undergoing in vitro fertilization some people
+
+497
+00:35:56,180 --> 00:35:59,000
+preferred egg fertilization to embryo freezing for
+
+498
+00:35:59,000 --> 00:36:03,980
+ethical reasons women wish to preserve young egg
+
+499
+00:36:03,980 --> 00:36:07,620
+now for future use يعني في أكتر من حالة من حالات
+
+500
+00:36:07,620 --> 00:36:11,640
+اللي حاليا صارت المشكلة تظهر على الصدح بكميات
+
+501
+00:36:11,640 --> 00:36:16,810
+كبيرة جدا و في مجتمعاتنا العربيةخصوصا في الناس
+
+502
+00:36:16,810 --> 00:36:20,270
+اللي بتشتغل as fashionist على سبيل المثال بتقوم
+
+503
+00:36:20,270 --> 00:36:26,430
+بتخزين بوايضاتها الشابة علشان مايصير عملية إنجاب
+
+504
+00:36:26,430 --> 00:36:30,570
+وعملية حمل خلال فترة عملها على سبيل المثال و بعد
+
+505
+00:36:30,570 --> 00:36:34,210
+فترة زمانية عشر سنين عشرين سنة whatever يعني ال
+
+506
+00:36:34,210 --> 00:36:38,410
+calendar الخاصة فيها وقت ما بدها تنجب تروح تستخدم
+
+507
+00:36:38,410 --> 00:36:41,590
+البوايضات المخزنة زي ما في عندنا sperm banking في
+
+508
+00:36:41,590 --> 00:36:45,070
+عندنا oocyte banking صار حالياحتى الـ oxide
+
+509
+00:36:45,070 --> 00:36:48,130
+banking ممكن تؤجر ممكن تباع زي الـ spare banking
+
+510
+00:36:48,130 --> 00:36:52,190
+ممكن تباع مافي مشكلة بس طبعا هذا مش في مجتمعاتنا
+
+511
+00:36:52,190 --> 00:36:56,150
+موجودة في المجتمعات الغربية ولكن في مجتمعاتنا بدأت
+
+512
+00:36:56,150 --> 00:37:00,310
+تظهر ظاهرة جديدة وهي الظاهرة الموجودة في آخر ال
+
+513
+00:37:00,310 --> 00:37:04,310
+slide التي بعنوان women wish to preserve younger
+
+514
+00:37:04,310 --> 00:37:12,180
+egg now for if youth are used طبعاخلال عملية الـ
+
+515
+00:37:12,180 --> 00:37:15,300
+Cryopreservation أو الـ freezing للـ Oocyte الـ
+
+516
+00:37:15,300 --> 00:37:18,680
+Oocyte ما بتتمهد العملية بشكل سلس بشكل سهل الـ
+
+517
+00:37:18,680 --> 00:37:22,900
+Oocyte بتتعرض لعديد من الـ challenging لعديد من
+
+518
+00:37:22,900 --> 00:37:26,480
+المخاطر قد تؤدي إلى حدوث rupture في الـ Oocyte
+
+519
+00:37:26,480 --> 00:37:32,660
+وفقدان الـ Oocyte بفعل تكوين crystal ice داخل الـ
+
+520
+00:37:32,660 --> 00:37:36,640
+cytoplasm الخاص بالـ Oocyte مما يؤدي إلى تمزيق
+
+521
+00:37:36,640 --> 00:37:40,410
+الغشاء الخلوي الخاص بالـ Oocyte white layerهذه
+
+522
+00:37:40,410 --> 00:37:45,850
+أشهر المعوقات التي تتواجه
+
+523
+00:37:45,850 --> 00:37:48,950
+الـ oocyte خلال عملية الـ freezing أو الـ
+
+524
+00:37:48,950 --> 00:37:51,390
+cryopreservation ممكن أن أتجنب تكوين ال ice
+
+525
+00:37:51,390 --> 00:37:56,070
+crystal and toxic concentration of salt which are
+
+526
+00:37:56,070 --> 00:37:59,130
+the two main cause of the cell death associated
+
+527
+00:37:59,130 --> 00:38:02,110
+with cryopreservation while maintaining the
+
+528
+00:38:02,110 --> 00:38:05,010
+functional of intracellular organelle and the
+
+529
+00:38:05,010 --> 00:38:10,070
+viability of the embryo oocyteيعني أشهر نقطتين
+
+530
+00:38:10,070 --> 00:38:14,270
+تتعرض إليه أو خطريًا تتعرض إليهم الـ oocyte خلال
+
+531
+00:38:14,270 --> 00:38:18,470
+عملية الـ cryopreservation أو الـ freezing تكوين
+
+532
+00:38:18,470 --> 00:38:23,850
+ال ice crystal و ال toxicity الخاصة بالمواد التي
+
+533
+00:38:23,850 --> 00:38:29,170
+تستخدم ولكن حاليًا أصبح هناك إمكانية أن أمنع خطر
+
+534
+00:38:29,170 --> 00:38:32,890
+النقطتين هدولة من خلال استخدام ما يعرف باسم الـ
+
+535
+00:38:32,890 --> 00:38:38,140
+cryoprotective additive or cryoprotective agentإذن
+
+536
+00:38:38,140 --> 00:38:42,100
+هناك خطرين تواجهها البويضة خلال عملية التخزين
+
+537
+00:38:42,100 --> 00:38:47,000
+تكوين ال ice crystal خطر و ال toxicity الخاصة
+
+538
+00:38:47,000 --> 00:38:51,080
+بالمواد المستخدمة ممكن أنا أتجنب هذا الخطرين من
+
+539
+00:38:51,080 --> 00:38:55,140
+خلال استخدام شيء بسميه CPA و هي cryoprotective
+
+540
+00:38:55,140 --> 00:38:59,060
+agentمن أشهر الـ cryoprotective agent هنتكلم عنها
+
+541
+00:38:59,060 --> 00:39:02,880
+كمان شوية exposure to cryoprotective agent support
+
+542
+00:39:02,880 --> 00:39:05,640
+the dehydration of the cell and reduce
+
+543
+00:39:05,640 --> 00:39:08,920
+intracellular ice formation إذن ال cryoprotective
+
+544
+00:39:08,920 --> 00:39:13,200
+agent بعمل dehydration للخلية فبالتالي بنزع منها
+
+545
+00:39:13,200 --> 00:39:16,780
+الماء فبالتالي ما بتتكون ال ice crystal داخل
+
+546
+00:39:16,780 --> 00:39:21,230
+الخليةمن أشهر الـ CBA على سبيل المثال، هنتقسم إلى
+
+547
+00:39:21,230 --> 00:39:24,270
+قسمين القسم الأول بيسميه Intracellular والقسم
+
+548
+00:39:24,270 --> 00:39:27,730
+التاني بيسميه Extracellular الـ Intracellular
+
+549
+00:39:27,730 --> 00:39:33,330
+membrane permitting زي Glucerol، Dimethylglucerol
+
+550
+00:39:33,330 --> 00:39:40,390
+والإيثيلينيجليسرول إذا عندي الجليكول،
+
+551
+00:39:40,390 --> 00:39:44,230
+Dimethylglucerol، إيثيلينيجليكول أربع أنواع من
+
+552
+00:39:44,230 --> 00:39:49,520
+أنواع الـ Intracellular membrane permittingأما الـ
+
+553
+00:39:49,520 --> 00:39:53,500
+Extracellular Membrane Non-permenting زي السكاروز
+
+554
+00:39:53,500 --> 00:39:58,040
+والجليكوز والأميند والبروتينز والليبوبروتينز إذا
+
+555
+00:39:58,040 --> 00:40:01,420
+في عندي نوعين منهم واحد Intracellular وواحد
+
+556
+00:40:01,420 --> 00:40:08,760
+Extracellular طبعا الـ Pre-Nipple-CPA Removing
+
+557
+00:40:08,760 --> 00:40:14,300
+Water بشتغل على إزالة الـ Intracellular بشتغل على
+
+558
+00:40:14,300 --> 00:40:19,380
+إزالة الماء من داخل الـ Oocyteمن خلال الإزالة
+
+559
+00:40:19,380 --> 00:40:23,360
+التدريجية Why? An osmotic gradient and partially
+
+560
+00:40:23,360 --> 00:40:26,580
+occupy the place of intracellular water while the
+
+561
+00:40:26,580 --> 00:40:29,880
+extracellular في المقابل Extracellular increase
+
+562
+00:40:29,880 --> 00:40:34,580
+the extracellular osmolarity generating an osmotic
+
+563
+00:40:34,580 --> 00:40:37,420
+gradient across the cell membrane supporting the
+
+564
+00:40:37,420 --> 00:40:39,800
+dehydration of the cell before CP
+
+565
+00:40:42,590 --> 00:40:46,190
+إذن في هندي طريقتين للعمل الطريقة الـ
+
+566
+00:40:46,190 --> 00:40:49,210
+intracellular إنه بعمل removing للماء الموجود داخل
+
+567
+00:40:49,210 --> 00:40:53,430
+الخلية من خلال الـ osmotic gradient و بحتل مكان
+
+568
+00:40:53,430 --> 00:40:56,750
+الماء بشكل تدريجي في المقابل الـ extracellular
+
+569
+00:40:56,750 --> 00:41:01,510
+بعمل زيادة للـ extracellular osmolarity مما يؤدي
+
+570
+00:41:01,510 --> 00:41:06,090
+إلى إخراج الماء بشكل كاملوعمل ال dehydration ولكن
+
+571
+00:41:06,090 --> 00:41:10,570
+تحدث قبل ال CB والمقصود بال CB في هذه الفقرة مقصود
+
+572
+00:41:10,570 --> 00:41:15,490
+بال CB هي ال cryopreservation at the same time it
+
+573
+00:41:15,490 --> 00:41:18,050
+prevents the rapidly enter of the water into the
+
+574
+00:41:18,050 --> 00:41:21,170
+cell after thawing during rehydration of the
+
+575
+00:41:21,170 --> 00:41:26,410
+permitting CBA طيب اي بوادة صارلة freezing او
+
+576
+00:41:26,410 --> 00:41:29,250
+صارلة cryopreservation لما بدي استخدمها لازم
+
+577
+00:41:29,250 --> 00:41:34,130
+اعملها thawing شو يعني thawing يعني اذابةبدي
+
+578
+00:41:34,130 --> 00:41:39,350
+أعملها إذابة و أرجعها ضيبل فالـ intracellular في
+
+579
+00:41:39,350 --> 00:41:43,990
+نفس اللحظة أنه هو بيحافظ على ال oocyte خلال عملية
+
+580
+00:41:43,990 --> 00:41:47,590
+ال cryopreservation أيضا بيحافظ على ال oocyte خلال
+
+581
+00:41:47,590 --> 00:41:52,410
+عملية thawing من خلال شو؟ من خلال منع ما يسمى
+
+582
+00:41:52,410 --> 00:41:56,290
+rabbit enter of water into the cell after thawing
+
+583
+00:41:56,290 --> 00:42:00,270
+يعني بيمنع دخول الماء أو بيمنع دخول الماء السريع
+
+584
+00:42:00,270 --> 00:42:06,390
+داخل ال oocyte خلال عمليةالاذابة أو عملية الاذابة
+
+585
+00:42:06,390 --> 00:42:10,170
+أو عملية الـrehydration مما يحافظ على البويضة في
+
+586
+00:42:10,170 --> 00:42:15,790
+أفضل صورة ممكنة لها إذن الـIntracellular ما بحمل
+
+587
+00:42:15,790 --> 00:42:20,430
+بويضة خلال عملية التجميد فقط لأ بحميها خلال عملية
+
+588
+00:42:20,430 --> 00:42:24,530
+الـrehydration من خلال إيقاف عملية تدفق الماء
+
+589
+00:42:24,530 --> 00:42:29,550
+السريع داخل البويضة خلال أو بعد عملية الـthaw
+
+590
+00:42:31,020 --> 00:42:33,200
+Dehydration of the cell mainly depending on the
+
+591
+00:42:33,200 --> 00:42:36,680
+permeability properties of the cell membraneدخول
+
+592
+00:42:36,680 --> 00:42:39,120
+الماء وخروج الماء و بالذات أنا بحكي هنا على الـ
+
+593
+00:42:39,120 --> 00:42:41,420
+dehydration خروج الماء خلال عملية الـ
+
+594
+00:42:41,420 --> 00:42:45,360
+cryopreservation يعتمد بشكل أساسي على ال
+
+595
+00:42:45,360 --> 00:42:47,360
+permeability of the cell membrane إذا كانت ال cell
+
+596
+00:42:47,360 --> 00:42:50,660
+membrane permeability جيدة إذا العملية استقول
+
+597
+00:42:50,660 --> 00:42:54,440
+وتنتهي بنجاح ال permeability properties of the
+
+598
+00:42:54,440 --> 00:42:58,160
+immature and mature oocyte different and can be
+
+599
+00:42:58,160 --> 00:43:02,320
+there by seven fold between individual human of
+
+600
+00:43:03,160 --> 00:43:07,600
+Oocite in the Metaphase-II أكيد طالما أنا عندي
+
+601
+00:43:07,600 --> 00:43:11,140
+Oocite هذا الـ Oocite لما تكون mature ال
+
+602
+00:43:11,140 --> 00:43:15,320
+permeability تختلف عنما تكون immature فبالتالي في
+
+603
+00:43:15,320 --> 00:43:19,940
+اختلاف هذا الاختلاف يقدر بسبع مرات مختلف أو سبع
+
+604
+00:43:19,940 --> 00:43:24,320
+أضعاف الاختلاف بين permeability of mature Oocite
+
+605
+00:43:24,320 --> 00:43:27,930
+and immature Oociteهذا الاختلاف في الـ
+
+606
+00:43:27,930 --> 00:43:31,730
+permeability البرميابيات قد تتأثر قوة قوة على
+
+607
+00:43:31,730 --> 00:43:35,170
+نتيجة الانتقال اللازمة من الـ oocyte لكنها يمكن أن
+
+608
+00:43:35,170 --> 00:43:39,290
+تكون تحكم بإنعكاس مقاومة الـ non-permeability الـ
+
+609
+00:43:39,290 --> 00:43:44,090
+CpA ومقاومة البيئة طالما أن في عندي permeability
+
+610
+00:43:44,090 --> 00:43:46,510
+مختلفة ما بين ال mature oocyte و ال immature
+
+611
+00:43:46,510 --> 00:43:51,430
+oocyte هذا الاختلاف وجدوا أنه بلعب دور كبير جدا في
+
+612
+00:43:51,910 --> 00:43:59,590
+الـ outcome of cell freezing يعني نجاح
+
+613
+00:43:59,590 --> 00:44:02,830
+الـ oocyte freezing باستخدام ال slow method هل
+
+614
+00:44:02,830 --> 00:44:07,360
+تنجح أم لا تنجح؟ولكن في المقابل وجدوا أن هناك
+
+615
+00:44:07,360 --> 00:44:11,920
+قابلية للتحكم في هذا الأمر من خلال زيادة مستوى للـ
+
+616
+00:44:11,920 --> 00:44:14,760
+cryoprotective agent اللي بيستخدموه و خاصة إن إذا
+
+617
+00:44:14,760 --> 00:44:18,280
+كان intracellular و خاصة إن إذا كان عفوا non
+
+618
+00:44:18,280 --> 00:44:21,300
+permeable وهو الـ extracellular بالإضافة إلى
+
+619
+00:44:21,300 --> 00:44:25,040
+التحكم في كمية الحرارة ال environment temperature
+
+620
+00:44:25,040 --> 00:44:28,940
+الموجودة إذا مافي حاجة اسمها خطأ مطلق مافي حاجة
+
+621
+00:44:28,940 --> 00:44:33,510
+اسمها عامل يؤثر بشكل مطلقلأ في عندي إمكانية للتحكم
+
+622
+00:44:33,510 --> 00:44:38,070
+في هذه الأمور By having the concentration of non
+
+623
+00:44:38,070 --> 00:44:44,530
+-permitting cryoprotective agent increase عن طريق
+
+624
+00:44:44,530 --> 00:44:51,350
+زيادة ال-CPA كتركيزه فممكن أستخدم سكروز 0.2 أو 0.3
+
+625
+00:44:51,350 --> 00:44:55,170
+مولار وخدوا بالك أنا قلت non-permitting يعني عبارة
+
+626
+00:44:55,170 --> 00:45:01,200
+عنبناء على هذه الصورة الـ Extracellular
+
+627
+00:45:01,200 --> 00:45:06,760
+فممكن أزيدها لتصل تركيز السكاروز as CpA إلى 0.2 أو
+
+628
+00:45:06,760 --> 00:45:12,140
+0.3 مولار هذا بعمل زيادة في survivor rate لل
+
+629
+00:45:12,140 --> 00:45:16,720
+oocyte خلال عملية freezing over all freezing
+
+630
+00:45:16,720 --> 00:45:20,020
+fertilization rate of freezing thawing oocyte
+
+631
+00:45:20,020 --> 00:45:25,180
+appeared to be similar to those of fresh oocyteعن
+
+632
+00:45:25,180 --> 00:45:30,320
+زيادة الـ CBA concentration علشان يصل إلى 0.2 أو 0
+
+633
+00:45:30,320 --> 00:45:35,420
+.3 مولار بيخلّي ال survival rate عالي جدا بيخلّي
+
+634
+00:45:35,420 --> 00:45:39,940
+ال fertilization rate للبوايضة المقصبة التي نتجت
+
+635
+00:45:39,940 --> 00:45:43,300
+بعد عملية ال throwing تشبه ال fertilization rate
+
+636
+00:45:43,300 --> 00:45:47,280
+للبوايضة ال fresh يعني مافي عندى اختلاف؟ اه مافي
+
+637
+00:45:47,280 --> 00:45:51,000
+عندى اختلاف بناهن طبعا هذا مش اراه بناهن على أبحاث
+
+638
+00:45:51,000 --> 00:45:55,980
+و دراسات أجريا على بوايضاتخُصّبت بعد أن حدث لها
+
+639
+00:45:55,980 --> 00:45:58,900
+عملية thawing وهي تعرضت لـ cryopreservation
+
+640
+00:45:58,900 --> 00:46:02,940
+باستخدام الـCPA الـexternal extracellular بتركيز 0
+
+641
+00:46:02,940 --> 00:46:09,340
+.2 و 0.3 مولار طبعا قبل الـslow cooling
+
+642
+00:46:09,340 --> 00:46:12,420
+dehydration of the embryo site is carried out by
+
+643
+00:46:12,420 --> 00:46:16,830
+exposure to a mixture ofPermeable and non
+
+644
+00:46:16,830 --> 00:46:20,570
+-permeable CBA duration 10 minutes يعني ممكن انا
+
+645
+00:46:20,570 --> 00:46:26,990
+ازيد كمان ال survivor rate لل Oocyte و امنع ال bad
+
+646
+00:46:26,990 --> 00:46:32,790
+effect ل ال CBA من خلال عمل mixing أو تعريض ال
+
+647
+00:46:32,790 --> 00:46:36,490
+Oocyte لخليط من ال intracellular و ال
+
+648
+00:46:36,490 --> 00:46:41,870
+extracellular CBA لمدة عشرة minutes Currently
+
+649
+00:46:41,870 --> 00:46:46,820
+there are two methodsحالياً في عندى طريقتين لعملية
+
+650
+00:46:46,820 --> 00:46:49,740
+ال freezing طريقة بتسميها slow rate freezing و هي
+
+651
+00:46:49,740 --> 00:46:53,240
+طريقة بضيئة جدا بتاخد تلت ساعات او سعتين بناء على
+
+652
+00:46:53,240 --> 00:46:56,240
+ال machine المستخدمة و طريقة بتسميها طريقة سريعة
+
+653
+00:46:56,240 --> 00:46:59,580
+بتسميها ال vitrification اذا في عندنا ال oocyte و
+
+654
+00:46:59,580 --> 00:47:02,560
+ال embryo طريقتين لعملية ال freezing طريقة ال slow
+
+655
+00:47:02,560 --> 00:47:07,720
+rate freezing و هى تعتمد على machine و طريقة اسمها
+
+656
+00:47:07,720 --> 00:47:09,300
+very fast او verification
+
+657
+00:47:13,020 --> 00:47:16,700
+طبعاً في مختبرات بتستخدم الطريقة الأولى وطريقة
+
+658
+00:47:16,700 --> 00:47:20,280
+ناجحة وفي مختبرات بسبب الضغط اللي عمل عليها
+
+659
+00:47:20,280 --> 00:47:23,400
+بتستخدم طريقة ال vitrification طريقة ناجحة بشكل
+
+660
+00:47:23,400 --> 00:47:27,840
+كبير جدا تاخدش تقريبا دقيقة واحدة during rib
+
+661
+00:47:27,840 --> 00:47:32,540
+reservation cell are exposed to a number of stress
+
+662
+00:47:32,540 --> 00:47:35,940
+factors mechanical, thermal, chemical which can
+
+663
+00:47:35,940 --> 00:47:39,620
+lead to defect the cell functional and lead to
+
+664
+00:47:39,620 --> 00:47:42,350
+cell deathيعني خلال عملية الـ Crime Preservation
+
+665
+00:47:42,350 --> 00:47:47,070
+الخلية ما بتكون منعمة ما بتكون في بيئة optimal
+
+666
+00:47:47,070 --> 00:47:51,890
+condition لأ بتتعرض إلى بعض العوامل الضغطة سواء
+
+667
+00:47:51,890 --> 00:47:55,070
+كانت عوامل كيميائية أو بيئية أو حرارية أو
+
+668
+00:47:55,070 --> 00:47:59,010
+ميكانيكية وانت بتشتغل وانت بتضغط عليها باستخدام ال
+
+669
+00:47:59,010 --> 00:48:03,830
+needle هذه كلها عوامل ممكن تؤدي إلى قتل الخلية أو
+
+670
+00:48:03,830 --> 00:48:08,490
+تؤدي إلى إيقاف وظيفتها إلى إيقاف وظيفتها بشكل عام
+
+671
+00:48:10,790 --> 00:48:13,630
+It has been demonstrated that oocyte are more
+
+672
+00:48:13,630 --> 00:48:17,470
+sensitive to cryodamage than later embryonic stage
+
+673
+00:48:17,470 --> 00:48:23,050
+بشكل عام حكوا ووجدوا أن البويضة إذا تعرضت لـ
+
+674
+00:48:23,050 --> 00:48:26,230
+Cryopreservation هيكون فرصة تدميرها أكتر من ال
+
+675
+00:48:26,230 --> 00:48:29,330
+embryo لأن ال embryo عنده resistant عالية ال
+
+676
+00:48:29,330 --> 00:48:33,770
+oocyte sensitive عشان كده معظم المراكز بيميلوا إلى
+
+677
+00:48:33,770 --> 00:48:37,890
+تجميد الأجنة و ليس إلى تجميد البويضة لأن البويضة
+
+678
+00:48:37,890 --> 00:48:41,910
+بين لحظة و تانية ممكن تتلفبينما الأجنة مقاومتها
+
+679
+00:48:41,910 --> 00:48:45,450
+للتلف بفعل ال cryopreservation بتكون أعلى يعني ال
+
+680
+00:48:45,450 --> 00:48:49,910
+survival rate تبعتها أعلى slow rate of freezing
+
+681
+00:48:49,910 --> 00:48:53,730
+attempt to control biophysical properties of
+
+682
+00:48:53,730 --> 00:48:57,730
+freezing such as a cooling and warming grade in
+
+683
+00:48:57,730 --> 00:49:02,710
+conjunction with cryoprotectant to minimize advice
+
+684
+00:49:02,710 --> 00:49:08,210
+cellular even يعني فكرة slow freezing methodهي
+
+685
+00:49:08,210 --> 00:49:13,210
+طريقة تعتمد على التحكم في درجات انخفاض الحرارة
+
+686
+00:49:13,210 --> 00:49:17,430
+ودرجات ارتفاع الحرارة اعتمادًا على كمية الـ
+
+687
+00:49:17,430 --> 00:49:21,150
+cryoprotectant الموجودة من أجل تقليل التأثير
+
+688
+00:49:21,150 --> 00:49:25,850
+السلبي الخاص بالـ cellular event اللي بتحدث خلال
+
+689
+00:49:25,850 --> 00:49:30,630
+عملية الـ cryopreservation في الـ slow freezing
+
+690
+00:49:30,630 --> 00:49:35,030
+method بيصير cooling للخلايا to very low
+
+691
+00:49:35,030 --> 00:49:38,650
+temperaturecirculating الخلايا لدرجة حرارة مخاطرة
+
+692
+00:49:38,650 --> 00:49:43,490
+جدا قد تصل إلى minus 30 كعدد درجة الحرارة التي يتم
+
+693
+00:49:43,490 --> 00:49:46,590
+تناقصها في الدقيقة الواحدة while minimizing
+
+694
+00:49:46,590 --> 00:49:50,430
+intracellular ice crystal formation and at the
+
+695
+00:49:50,430 --> 00:49:52,990
+same time attempt to minimize the harmful
+
+696
+00:49:52,990 --> 00:49:56,390
+influence of increased salient concentration and
+
+697
+00:49:56,390 --> 00:50:00,730
+osmotic stress إذن في ال slow freezing method هي
+
+698
+00:50:00,730 --> 00:50:06,150
+طريقة تعمل على تبريد الخلايالكي تصل إلى درجة حرارة
+
+699
+00:50:06,150 --> 00:50:10,770
+منخفضة جدا جدا بشرط أن تحافظ على الـfunctional of
+
+700
+00:50:10,770 --> 00:50:16,290
+oocyte or embryo تقلل من تأثير التركيز المرتفعة
+
+701
+00:50:16,290 --> 00:50:21,230
+للمواد التي تستخدم و التي تؤدي إلى إطلاف الخلية
+
+702
+00:50:21,230 --> 00:50:25,510
+بالإضافة إلى تقليل التأثير السلبي للـosmotic
+
+703
+00:50:25,510 --> 00:50:29,610
+stress الـvetrification بيصير في عندي مش slow
+
+704
+00:50:29,610 --> 00:50:32,850
+freezing لأ rapid freezing انه بيصير عملية cooling
+
+705
+00:50:32,850 --> 00:50:38,050
+سريع جداباستخدام تركيز عالمي الـ cryoprotectant
+
+706
+00:50:38,050 --> 00:50:43,290
+that solidified without forming ice crystal يعني
+
+707
+00:50:43,290 --> 00:50:47,450
+الventrification تبريد سريع جدا باستخدام تركيز
+
+708
+00:50:47,450 --> 00:50:51,090
+عالمي الـ cryoprotectant منع تكوين ال ice crystal
+
+709
+00:50:51,090 --> 00:50:56,070
+هناخد ايش الفرق بين كل طريقة او اخرى على سبيل
+
+710
+00:50:56,070 --> 00:50:59,230
+المثال، ان verification تقنيكي ال oocyte و ال
+
+711
+00:50:59,230 --> 00:51:04,070
+embryo بصيرها dehydrationقبل عملية ال cooling من
+
+712
+00:51:04,070 --> 00:51:07,870
+خلال تعريضها إلى concentrating solution of the
+
+713
+00:51:07,870 --> 00:51:11,570
+cribrotectin before plugging the sample directly
+
+714
+00:51:11,570 --> 00:51:14,310
+into liquid nitrogen بمعنى آخر أنه أنا بجيب
+
+715
+00:51:14,310 --> 00:51:18,250
+البويضة البويضة بحضنها مع تركيز عالي من
+
+716
+00:51:18,250 --> 00:51:23,950
+cribrotectin بيخليها بيصلها dehydration بعدين باخد
+
+717
+00:51:23,950 --> 00:51:27,250
+البويضة و بلقيهافي الـ liquid nitrogen طبعا مش
+
+718
+00:51:27,250 --> 00:51:30,510
+بلقيها بلقيها بعد الشكل لأ فيها طريقة معينة انه
+
+719
+00:51:30,510 --> 00:51:34,710
+بستخدمها في حاجة بتسميها strip هنشوفها كمان شوية
+
+720
+00:51:34,710 --> 00:51:40,650
+زي الحاضنة طبعا كيف عملية ال freezing بتتم with
+
+721
+00:51:40,650 --> 00:51:44,830
+low cooling rate تصل إلى point three لكل دقيقة
+
+722
+00:51:44,830 --> 00:51:48,850
+يعني بيصير عملية اخفاض درجة حرارة point تلاتة درجة
+
+723
+00:51:48,850 --> 00:51:55,130
+لكل دقيقة to about minus30 سلسيوس لـ 40 سلسيوس
+
+724
+00:51:55,130 --> 00:52:02,030
+تتبع بإزالة حرارة الهواء لـ-50 سلسيوس في ساعة
+
+725
+00:52:02,030 --> 00:52:10,470
+لتحرير من الـ-80 سلسيوس لـ-150 سلسيوس قبل البداية
+
+726
+00:52:10,470 --> 00:52:14,430
+الانفجار بالنيتوجين الليلي يعني بصير عندي اخفاض
+
+727
+00:52:14,430 --> 00:52:19,800
+وانخفاض تدريجي في درجة الحرارةمن سالب تلاتين لسالب
+
+728
+00:52:19,800 --> 00:52:24,860
+أربعين كل دقيقة بعدين بيرتفع من سالب خمسين لسالب
+
+729
+00:52:24,860 --> 00:52:28,380
+سالب خمسين لكل دقيقة بعدين بيصير من سالب تمانين
+
+730
+00:52:28,380 --> 00:52:33,240
+لسالب مية وخمسين لكل دقيقة شوف جديش عملية انخفاض
+
+731
+00:52:33,240 --> 00:52:37,700
+درجة الحرارة معدل انخفاضها طبعا لازم تصل لسالب مية
+
+732
+00:52:37,700 --> 00:52:42,540
+وخمسين درجة قبل إلقاء في ال liquid nitrogen طيب
+
+733
+00:52:42,540 --> 00:52:47,210
+خلال ال during او خلال slow coolingبصير
+
+734
+00:52:47,210 --> 00:52:50,130
+dehydration وبعدين بصير عندى حاجة بتسميها
+
+735
+00:52:50,130 --> 00:52:56,230
+continuous reduction for oocyte temperature أو
+
+736
+00:52:56,230 --> 00:53:01,610
+خلّيني أسميه continuous reduction for temperature
+
+737
+00:53:01,610 --> 00:53:06,840
+قد تصل إلى ماينس تلاتين درجة after whichany
+
+738
+00:53:06,840 --> 00:53:12,060
+remaining water is super cooling هذا عبارة عن
+
+739
+00:53:12,060 --> 00:53:15,400
+العملية يعني بيصير خلال slow cooling بيصير في عندي
+
+740
+00:53:15,400 --> 00:53:19,800
+dehydration للفويدة وبعدين بيصير عندي خفض لدرجة
+
+741
+00:53:19,800 --> 00:53:24,940
+الحرارة بشكل مستمر بمعدل سالب تلاتين قبل ما انا
+
+742
+00:53:24,940 --> 00:53:29,640
+استخدم ال liquid نيتروجين فيها اذا هذه فكرة ال
+
+743
+00:53:29,640 --> 00:53:31,980
+cooling slow cooling او ال vitrification
+
+744
+00:53:35,900 --> 00:53:40,480
+الـ Embryo and oocyte cooled slowly to sub-zero
+
+745
+00:53:40,480 --> 00:53:45,140
+temperature of minus 30 to minus 40 Celsius before
+
+746
+00:53:45,140 --> 00:53:51,780
+rapidly cooling to arrive minus 196 Celsius
+
+747
+00:53:51,780 --> 00:53:55,520
+required rapidly warming thawing in warm water of
+
+748
+00:53:55,520 --> 00:54:00,400
+25 Celsius to 37 Celsius يعني بيقوللي ببساطة اللي
+
+749
+00:54:00,400 --> 00:54:05,560
+ال embryo هتخضع إلى عملية التبريد التدريجي والبطير
+
+750
+00:54:05,820 --> 00:54:10,600
+لكي تصل إلى درجة حرارة أقل من السفر أو تحت السفر
+
+751
+00:54:10,600 --> 00:54:15,340
+تصل إلى سالب تلاتين بعدين سالب أربعين بعدين تستمر
+
+752
+00:54:15,340 --> 00:54:18,880
+في التناقص بشكل تدريجي لتصل إلى سالب مية وستة
+
+753
+00:54:18,880 --> 00:54:24,120
+وتسعين درجة مائوية وهي في الغالب درجة حرارة liquid
+
+754
+00:54:24,120 --> 00:54:28,140
+nitrogen liquid nitrogen درجة حرارته سالب مية وستة
+
+755
+00:54:28,140 --> 00:54:32,720
+وتسعين درجة مائوية طبعا خلال هذه العملية خلاص
+
+756
+00:54:32,720 --> 00:54:36,780
+اتجمدت البويضةبدأ أرجع عملها thawing لازم أضيفه أو
+
+757
+00:54:36,780 --> 00:54:42,340
+أوضعها في حمام مائي بصل درجة حرارته 25 إلى 37 درجة
+
+758
+00:54:42,340 --> 00:54:46,980
+معوية Rapid thawing is followed by remove the CPA
+
+759
+00:54:46,980 --> 00:54:51,800
+from the embryo and oocyte شو بيصير و شو بيحدث
+
+760
+00:54:51,800 --> 00:54:56,960
+خلال عملية ال thawing بتم عملية إزالة و إخراج ال
+
+761
+00:54:56,960 --> 00:55:00,160
+cryoprotective agent الموجود داخل ال embryo أو
+
+762
+00:55:00,160 --> 00:55:03,500
+الموجود داخل البوادة أو التخلص منههيحل محله مين؟
+
+763
+00:55:03,500 --> 00:55:07,060
+هيحل محله الماء لأنه في الـ cryopreservation الماء
+
+764
+00:55:07,060 --> 00:55:11,620
+طلع ودخل مكانه الـCPA في الـthawing الـCPA بيطلع
+
+765
+00:55:11,620 --> 00:55:15,480
+وتحل محله الماء تحت مصطلح الـrehydration
+
+766
+00:55:15,480 --> 00:55:18,780
+rehydration of the cell is carried out in
+
+767
+00:55:18,780 --> 00:55:22,400
+increasing concentration of permitting CPA
+
+768
+00:55:22,400 --> 00:55:25,480
+generally in the presence of increased
+
+769
+00:55:25,480 --> 00:55:29,140
+concentration of non-permitting CPA إذا في عملية
+
+770
+00:55:29,140 --> 00:55:33,090
+الـthawingيعبارة عن عملية بنسميها Rehydration حيث
+
+771
+00:55:33,090 --> 00:55:38,810
+تبنزع وإخراج الـCPA ويحل محله الماء كما كانت
+
+772
+00:55:38,810 --> 00:55:44,790
+الخلية فيما سبق ال Petrification وهي المصطلح الآخر
+
+773
+00:55:44,790 --> 00:55:49,210
+اللي سموه Ultra Rapid Cryopreservation أول ما تم
+
+774
+00:55:49,210 --> 00:55:54,990
+استخدامه كان في بداية أو في منتصف عام 1980هي طريقة
+
+775
+00:55:54,990 --> 00:55:58,630
+تختلف بشكل كبير جدا عن slow freezing method يتم
+
+776
+00:55:58,630 --> 00:56:02,170
+فيها تجنب تكوين ال ice crystal in the
+
+777
+00:56:02,170 --> 00:56:06,290
+intracellular and extracellular space يعني مش فقط
+
+778
+00:56:06,290 --> 00:56:11,020
+بمنع تكوين ال ice crystalفي داخل الخلية الـ
+
+779
+00:56:11,020 --> 00:56:13,680
+Intracellular كمان بيعمل منع تكوينه في الـ
+
+780
+00:56:13,680 --> 00:56:19,120
+Extracellular في الـ Vitrification عملية يتم فيها
+
+781
+00:56:19,120 --> 00:56:23,260
+ببساطة إخفاء درجة الحرارة ومنع تكوين الـ ice
+
+782
+00:56:23,260 --> 00:56:28,500
+crystal من خلال الحصول و استخدام تركيز عالي من
+
+783
+00:56:28,500 --> 00:56:34,010
+الـCPA يصل إلى من 4 إلى 8 مول per literوتعريضها
+
+784
+00:56:34,010 --> 00:56:39,330
+لعملية التبريد السريع يعني ممكن تنزل لـ-196 خلال 3
+
+785
+00:56:39,330 --> 00:56:43,870
+دقائق فقط لغاية ماتاخدلاش ساعة أو ساعتين خلال ال
+
+786
+00:56:43,870 --> 00:56:48,090
+vitrification بيصير dehydration للبوايضة أو الجنين
+
+787
+00:56:48,090 --> 00:56:52,690
+قبل ما تتعرض إلى ال liquid nitrogen من خلال
+
+788
+00:56:52,690 --> 00:56:56,610
+تحضيرها مع تركيز علمي من ال CBA وهو ال
+
+789
+00:56:56,610 --> 00:57:01,060
+cryopreservating agentطبعاً في عندي potential risk
+
+790
+00:57:01,060 --> 00:57:03,260
+associated with the fertification procedure is the
+
+791
+00:57:03,260 --> 00:57:07,200
+high concentration of CPA بس بالإضافة إلى ال
+
+792
+00:57:07,200 --> 00:57:09,600
+toxicity اللي خاصة فيها يعني نفس ال factor اللي
+
+793
+00:57:09,600 --> 00:57:12,220
+ممكن يتأثر على نتيجة slow freezing هي نفس ال
+
+794
+00:57:12,220 --> 00:57:13,900
+factor اللي ممكن يتأثر على نتيجة ال
+
+795
+00:57:13,900 --> 00:57:16,480
+fertilification و هي عبارة عن التركيز العالية
+
+796
+00:57:16,480 --> 00:57:20,520
+للمواد الحافظة لإضافة إلى ال toxicity اللي خاصة
+
+797
+00:57:20,520 --> 00:57:24,220
+بها ال toxicity اللي خاصة بها ممكن أنا أعمل
+
+798
+00:57:24,220 --> 00:57:29,050
+limitation لهذا التأثير من خلال damageمراكبين مع
+
+799
+00:57:29,050 --> 00:57:33,350
+بعض من بعض، عمل mixing ل two compounds هذا بعمل
+
+800
+00:57:33,350 --> 00:57:38,190
+reducing the toxicity أو من خلال تقليل الوقت
+
+801
+00:57:38,190 --> 00:57:42,610
+اللازم أو وقت تعرض البويضة أو الجنين لهذه المواد،
+
+802
+00:57:42,610 --> 00:57:46,630
+لل-CPA يعني بدل ما أخليها عشر دقائق، بخليها خمس
+
+803
+00:57:46,630 --> 00:57:52,310
+دقائقطبعاً في بعض البرتقالات ميديا البرتقالات هي
+
+804
+00:57:52,310 --> 00:57:56,630
+ايضا مدعومة مع ميكرو مليكيول مثل بولي إيثيلين
+
+805
+00:57:56,630 --> 00:58:02,310
+إيجليكول أو بولي أو PVP بعض الأحيان الميديا أو
+
+806
+00:58:02,310 --> 00:58:05,090
+المواد ال CBA التي تستخدم في البرتقالات بتكون
+
+807
+00:58:05,090 --> 00:58:08,410
+مخلوطة بالميكرو مليكيول زي ال PVP وهي الميديا التي
+
+808
+00:58:08,410 --> 00:58:13,190
+استخدمت في إمبوليزاショن of spermatozoa أو استخدام
+
+809
+00:58:13,190 --> 00:58:18,000
+بولي إيثيلين إيجليكول فهي عبارةعن مواد بتعمل
+
+810
+00:58:18,000 --> 00:58:21,420
+increasing للviscosity the macromolecules support
+
+811
+00:58:21,420 --> 00:58:24,460
+vitrification with low concentration of CBA هذا
+
+812
+00:58:24,460 --> 00:58:28,620
+بتعمل زيادة للviscosity فبالتالي بتحتل مساحة أكبر
+
+813
+00:58:28,620 --> 00:58:33,300
+إضافة إلى بتعمل reduction لل toxicity level الخاصة
+
+814
+00:58:33,300 --> 00:58:38,340
+بال CBA طريقة بتوضح الكلام اللي أنا قلته في ال
+
+815
+00:58:38,340 --> 00:58:42,240
+vitrification أول حاجة باخد البويضة أو ال embryo
+
+816
+00:58:42,240 --> 00:58:45,960
+بعد اليوم التالت أو بعد اليوم الرابعبعمله
+
+817
+00:58:45,960 --> 00:58:48,980
+hybridization أو بعمله mixing أو بعمله incubation
+
+818
+00:58:48,980 --> 00:58:53,020
+مع الـCPA لمدة عشر دقائق أو عشرين دقيقة بناء على
+
+819
+00:58:53,020 --> 00:58:58,720
+ال protocol المستخدة هذه العملية بنسميها hydration
+
+820
+00:58:58,720 --> 00:59:03,720
+بعدين باخد البويضة أو ال embryo بضيفها في منطقة
+
+821
+00:59:03,720 --> 00:59:08,140
+بسميها small amount of cryoprotectant on the
+
+822
+00:59:08,140 --> 00:59:13,780
+cryovial بمعنى آخر أنه أنا حضنتها باخدالبوايضة
+
+823
+00:59:13,780 --> 00:59:19,420
+اللى موجودة في الـ Cups هذا بالـ Aspiration needle
+
+824
+00:59:19,420 --> 00:59:24,220
+بضيفها على .. في الـ catheter و بضيف عليها جزء من
+
+825
+00:59:24,220 --> 00:59:28,200
+ال media اللى أنا استخدمتها بعد كده باخد ال
+
+826
+00:59:28,200 --> 00:59:31,460
+catheter اللى أنا ضفط فيها البوايضة طبعا هذا كله
+
+827
+00:59:31,460 --> 00:59:33,560
+تحت الميكروسكوب بيصير يعني هذه العملية تحت
+
+828
+00:59:33,560 --> 00:59:36,100
+الميكروسكوب و هذه العملية تحت الميكروسكوب الوحيدة
+
+829
+00:59:36,100 --> 00:59:38,860
+اللى بتكون خارج الميكروسكوب عامل لإن ما بقدر أشوف
+
+830
+00:59:38,860 --> 00:59:41,880
+ال catheter و رفع ال catheter و العلامة اللى ..
+
+831
+00:59:42,070 --> 00:59:47,110
+محدد أضيف فيها ال egg أو ال oocyte بشكل سليم بعمل
+
+832
+00:59:47,110 --> 00:59:52,390
+عملية removing لل catheter و بعملها عملية putting
+
+833
+00:59:52,390 --> 00:59:56,250
+في ال liquid nitrogen لفترة زمنية معينة تقدر
+
+834
+00:59:56,250 --> 00:59:59,250
+بتلاتين ثانية اربعين ثانية بناء على ال protocol
+
+835
+00:59:59,250 --> 01:00:03,750
+المستخدم اذا shift it into liquid nitrogen where
+
+836
+01:00:03,750 --> 01:00:09,490
+high velocity cooling or rapid cooling for the
+
+837
+01:00:09,490 --> 01:00:13,550
+oocyte enable the eggto arrive vitrification stage
+
+838
+01:00:13,550 --> 01:00:18,330
+بعد كده باخد ال catheter هذه و بضيفه في ال tank of
+
+839
+01:00:18,330 --> 01:00:23,350
+liquid nitrogen لفترة زمنية اللي انا بحتاجها for
+
+840
+01:00:23,350 --> 01:00:26,990
+the next cycle هذه طريقة ال vitrification بشكل
+
+841
+01:00:26,990 --> 01:00:30,490
+بسيط خليني اشوف الفيديو اللي بتكلم عن هذا الموضوع
+
+842
+01:00:30,490 --> 01:00:33,850
+و كيف بتصير عملية ال vitrification
+
+843
+01:00:56,360 --> 01:00:58,620
+طبعا ال video notification بيكون عبارة عن زي كت
+
+844
+01:00:58,620 --> 01:01:00,020
+خاص فيها هذه ال catheter
+
+845
+01:01:27,190 --> 01:01:32,170
+طبعا بعدد أهميتها و إيش الوظائف المطلوبة منها أو
+
+846
+01:01:32,170 --> 01:01:37,510
+كيف بتقوم بهذه العملية طبعا في منها أنواع ما
+
+847
+01:01:37,510 --> 01:01:41,470
+بيعنينا الكلام هذا كله خلينا نشوف كيف عملية
+
+848
+01:01:41,470 --> 01:01:47,270
+العملية بتصير هي بهذا الشكل بدأ عملية إخراج ال
+
+849
+01:01:47,270 --> 01:01:53,870
+catheter أو إخراج ال strip خليني أسميهبضيف الـ
+
+850
+01:01:53,870 --> 01:01:58,030
+Label عليها علشان ما يصير عملية interference في
+
+851
+01:01:58,030 --> 01:02:08,090
+البيانات الـ ID الـ forceps بيخرج جزء منها طبعاً
+
+852
+01:02:08,090 --> 01:02:13,550
+بحطها في الـ Liquid nitrogen تحت
+
+853
+01:02:13,550 --> 01:02:19,070
+الميكروسكوب هياخد قلب ويدة هيضيفها ويعملها holding
+
+854
+01:02:19,070 --> 01:02:24,270
+على الـ strip الموجودأو الـ Straw في بعض الأحيان
+
+855
+01:02:24,270 --> 01:02:28,070
+بيسموها طبعا في لمكان محدد هذي بيسموها الزرجة
+
+856
+01:02:28,070 --> 01:02:33,910
+بيسموها ال Straw أو ال Strip بعد
+
+857
+01:02:33,910 --> 01:02:43,730
+كده لازم يعمل عملية إدخال للمحتوى في داخل و بلفها
+
+858
+01:02:43,730 --> 01:02:49,070
+عشان يسكرها كده عمل petrification ببساطة جدا كيف
+
+859
+01:02:49,070 --> 01:02:50,070
+بيعملها warming؟
+
+860
+01:02:55,240 --> 01:03:00,540
+عشان يعمل flowing يعني طبعا
+
+861
+01:03:00,540 --> 01:03:05,840
+في ال liquid nitrogen بيلفها لف عكسي علشان يفكها و
+
+862
+01:03:05,840 --> 01:03:09,260
+بيسحبها و بنتظر شوية في ال liquid nitrogen عشان
+
+863
+01:03:09,260 --> 01:03:13,980
+مايصير الشكلها و بعدين بنقلها على ال media الخاصة
+
+864
+01:03:13,980 --> 01:03:17,080
+فيها عشان كده ال vitrification تعتبر أسهل الطرق
+
+865
+01:03:17,080 --> 01:03:20,080
+التي تستخدمها مقارنة بسيطة بين ال slow freezing و
+
+866
+01:03:20,080 --> 01:03:23,060
+ال vitrificationالـ damage بيصير في ال low
+
+867
+01:03:23,060 --> 01:03:26,300
+freezing مافيش في ال vitrification دمج ل ال oocyte
+
+868
+01:03:26,300 --> 01:03:29,680
+من خلال تكوين ال ice crystal ال speed of freezing
+
+869
+01:03:29,680 --> 01:03:37,020
+تقدر ب 0.3 درجة
+
+870
+01:03:37,020 --> 01:03:40,100
+لكل minute في ال slow freezing و ال vitrification
+
+871
+01:03:40,100 --> 01:03:43,940
+بتصل ل 23 درجة لكل دقيقة بيصير reduction في ال
+
+872
+01:03:43,940 --> 01:03:48,270
+temperatureالـ Pre-protectant amounted very low،
+
+873
+01:03:48,270 --> 01:03:51,370
+very high في ال vitrification، ال survival rate
+
+874
+01:03:51,370 --> 01:03:56,070
+very low في ال slow freezing، في ال vitrification
+
+875
+01:03:56,070 --> 01:03:58,830
+عالية، ال procedure very simple في ال slow
+
+876
+01:03:58,830 --> 01:04:02,390
+freezing، في ال vitrification complex، لأنها
+
+877
+01:04:02,390 --> 01:04:07,490
+بتعتمد على الدقة والتركيز بشكل كبير جداطبعا ال
+
+878
+01:04:07,490 --> 01:04:10,930
+duration تأخد second ال vitrification slow
+
+879
+01:04:10,930 --> 01:04:14,190
+freezing ممكن تأخد ساعات control of dehydration
+
+880
+01:04:14,190 --> 01:04:16,910
+rate موجودة في ال vitrification مش موجودة في ال
+
+881
+01:04:16,910 --> 01:04:20,750
+slow freezing ال duration out of incubator عشرة
+
+882
+01:04:20,750 --> 01:04:22,950
+منت في ال vitrification تلاتة hour في ال slow
+
+883
+01:04:22,950 --> 01:04:27,050
+freezing زونة في اليوسيطة تصير تدمير في ال
+
+884
+01:04:27,050 --> 01:04:30,790
+vitrification لأ في ال slow freezing maybe ال
+
+885
+01:04:30,790 --> 01:04:33,950
+equipment and running cost inexpensive في ال
+
+886
+01:04:33,950 --> 01:04:38,250
+vitrification very expensiveتحتاج إلى machine ال
+
+887
+01:04:38,250 --> 01:04:42,050
+slow freezing في هذا القدر نكون قد أنهينا هذه
+
+888
+01:04:42,050 --> 01:04:47,230
+المحاضرة و أنهينا إلى حد ما معظم ال topics اللي
+
+889
+01:04:47,230 --> 01:04:51,350
+احنا اتوقعنا و كنا نحكي عليها خلال هذه المحاضرة
+
+890
+01:04:51,350 --> 01:04:56,550
+نرجو لكم التوفيق دائما و دمتم في حفظنا و رعايتنا
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/e8zUWOaK1rw.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/e8zUWOaK1rw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..9d0f5745b4820f0fac83da215b5c5be0786d49b3
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/e8zUWOaK1rw.srt
@@ -0,0 +1,2295 @@
+1
+00:00:01,480 --> 00:00:05,680
+باسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:05,680 --> 00:00:11,460
+المسلمين سيدنا محمد وعلى آله وصحبه أجمعين بداية 
+
+3
+00:00:11,460 --> 00:00:16,740
+نرجو من الله الكريم أن تكونوا جميعا بخير استكمالا 
+
+4
+00:00:16,740 --> 00:00:20,580
+لمبدأنا فيه من سلسلة محاضرات التلقيح الصناعي
+
+5
+00:00:20,580 --> 00:00:26,520
+أسبابه وسبوله وطرقه المتنوعة تحدثنا في الأسبوع
+
+6
+00:00:26,520 --> 00:00:35,040
+الماضي عن رحلة لسبيرم بداية من الـ cervix حتى وصولا
+
+7
+00:00:35,040 --> 00:00:37,860
+إلى ال fallopian tube من أجل حدوث عملية ال
+
+8
+00:00:37,860 --> 00:00:43,180
+fertilization وما يواجهه من مخاطر ومعويقات هذه
+
+9
+00:00:43,180 --> 00:00:49,140
+المخاطر والمعويقات تلعب دورا أساسيا في انقاص عدد
+
+10
+00:00:49,140 --> 00:00:53,380
+الـ sperm الذي قد يصل إلى البويضة وهذا أمر طبيعي
+
+11
+00:00:53,380 --> 00:00:58,160
+وأمر محمود ولكن بشرط أن لا يزيد عن الأمر الطبيعي
+
+12
+00:00:59,840 --> 00:01:04,340
+سنستكمل اليوم بعض النقاط المتعلقة بالـ Transport 
+
+13
+00:01:04,340 --> 00:01:09,260
+of Gametes and Fertilization وهو الجزء الثالث من
+
+14
+00:01:09,260 --> 00:01:12,260
+هذا الـ chapter والذي يتحدث عن آلية ال
+
+15
+00:01:12,260 --> 00:01:15,680
+fertilization كيف تحدث ال fertilization  وأين تحدث
+
+16
+00:01:15,680 --> 00:01:19,740
+عملية ال fertilization وما المانع من إخصاب البويضة 
+
+17
+00:01:19,740 --> 00:01:23,480
+بـ sperm وإن تم إخصاب البويضة بـ sperm ماذا سوف 
+
+18
+00:01:23,480 --> 00:01:28,200
+يحدث هذه أمور سوف نتطرق إليها خلال محاضرة الأسبوع 
+
+19
+00:01:28,200 --> 00:01:32,910
+الحالي إن شاء الله بداية وقبل أن نبدأ بعملية ال
+
+20
+00:01:32,910 --> 00:01:36,750
+fertilization توقفنا فيما سبق عند الكوربوس 
+
+21
+00:01:36,750 --> 00:01:41,610
+ليوتيوم وكيف ينتج هذا الجسم الأصفر وتحدثنا أن 
+
+22
+00:01:41,610 --> 00:01:44,370
+الجسم الأصفر في البداية هو عبارة عن ال Graafian 
+
+23
+00:01:44,370 --> 00:01:50,770
+follicle بعد عملية ال ovulation تتحول 
+
+24
+00:01:50,770 --> 00:01:57,290
+إلى كوربوس ليوتيوم بسبب بخ الدم بكمية كبيرة جدا
+
+25
+00:01:57,290 --> 00:02:02,220
+إلى هذه المنطقة وهذه المنطقة تلعب دورا مهمة في
+
+26
+00:02:02,220 --> 00:02:07,440
+إبقاء الحمل إن حدث من خلال إفراز بعض الهرمونات 
+
+27
+00:02:07,440 --> 00:02:11,040
+فبالتالي Ruptured Follicle بين جثين Giraffen 
+
+28
+00:02:11,040 --> 00:02:15,340
+Follicle undergoes a series of strict changes that 
+
+29
+00:02:15,340 --> 00:02:18,620
+are essentially for progression and of even
+
+30
+00:02:18,620 --> 00:02:23,500
+leading and supporting pregnancy يعني هذه التحولات
+
+31
+00:02:23,500 --> 00:02:26,400
+والتغيرات اللي بتصير على الـ Graafian follicle بعد
+
+32
+00:02:26,400 --> 00:02:30,460
+عملية ال ovulation تعتبر عاملًا حيويًا وعاملًا
+
+33
+00:02:30,460 --> 00:02:35,720
+أساسيًا في بقاء الحمل إن حدث وتدعيمه فبالتالي 
+
+34
+00:02:35,720 --> 00:02:40,360
+وجودها ليس بالأمر الافتراضي الذي يحدث بشكل عشوائي
+
+35
+00:02:41,510 --> 00:02:44,630
+فماذا يحدث بعد عملية الـ ovulation؟ مباشرة بعد
+
+36
+00:02:44,630 --> 00:02:47,730
+عملية الإبادة الـ basement membrane الخاص بالـ
+
+37
+00:02:47,730 --> 00:02:52,190
+Graafian follicle that's separated the granulosa 
+
+38
+00:02:52,190 --> 00:02:56,330
+cells from the theca breaks down thus allowing
+
+39
+00:02:56,330 --> 00:02:59,690
+thecal blood vessels to grow into the cavity of 
+
+40
+00:02:59,690 --> 00:03:04,310
+the ruptured follicle يعني عملية الـ separation 
+
+41
+00:03:04,310 --> 00:03:08,230
+اللي بتحدث ما بين الـ theca cells و ال granulosa
+
+42
+00:03:08,230 --> 00:03:12,180
+cells اللي موجودة في الـ basement membrane للـ
+
+43
+00:03:12,180 --> 00:03:16,140
+Graafian Follicle تسمح بضخ كمية كبيرة جدا من الدم
+
+44
+00:03:16,140 --> 00:03:22,780
+في هذه المنطقة مما يسمح بتكوين الكوربوس ليوتير
+
+45
+00:03:22,780 --> 00:03:25,480
+فيما بعد وهذا بيقولك allowing thecal blood
+
+46
+00:03:25,480 --> 00:03:28,140
+vessels الـ blood vessels الموجودة في الثيكا أنها
+
+47
+00:03:28,140 --> 00:03:33,030
+تنمو وتضخ كمية كبيرة جدا من الدم المحمل بالمواد 
+
+48
+00:03:33,030 --> 00:03:36,650
+الغذائية في الـ cavity بعد عملية الـ rupture الـ
+
+49
+00:03:36,650 --> 00:03:39,710
+granulosa cells تعمل stimulation أو بيصير لها
+
+50
+00:03:39,710 --> 00:03:43,030
+stimulation أو خلّيني أسميها بمعنى آخر بيصير لها 
+
+51
+00:03:43,030 --> 00:03:48,270
+variation و changing بفعل تلقائي مما يؤدي إلى 
+
+52
+00:03:48,270 --> 00:03:52,170
+سلسلة من التغيرات هذه التغيرات تحدث في الشكل وفي
+
+53
+00:03:52,170 --> 00:03:55,750
+الوظيفة نطلق على هذه التغيرات عملية بيسميها
+
+54
+00:03:55,750 --> 00:04:00,550
+لوتونيزيشن لذا اللوتونيزيشن هي a series or group 
+
+55
+00:04:00,550 --> 00:04:06,100
+of Modifications happened on granulosa cells لماذا
+
+56
+00:04:06,100 --> 00:04:11,040
+تحدث عن granulosa cells؟ لكي تخدم الوظيفة التي كانت
+
+57
+00:04:11,040 --> 00:04:15,540
+مكونة لأجلها فيما بعد إذا تحولت المكان إلى كورباس 
+
+58
+00:04:15,540 --> 00:04:18,100
+ليوتيام أو الفوليك الهادي تحول إلى كورباس
+
+59
+00:04:18,100 --> 00:04:23,960
+ليوتيام وبقيت لتخدم الحمل خلال ما يقارب من 30 إلى
+
+60
+00:04:23,960 --> 00:04:30,060
+40 ساعة بعد الـ LH wave بعد الـ high peak للـ LH 
+
+61
+00:04:30,060 --> 00:04:33,740
+احسب تلاتين لاربعين ساعة this cell اللي سميتها
+
+62
+00:04:33,740 --> 00:04:38,620
+granulosa cells تسمى فيما بعد أو تتحول فيما بعد إلى
+
+63
+00:04:38,620 --> 00:04:44,200
+خلايا أخرى تسمى granulosa lutein cells إذا ال
+
+64
+00:04:44,200 --> 00:04:46,720
+granulosa cells بعد ما يصير عليها ال modification
+
+65
+00:04:46,720 --> 00:04:51,240
+اللي احنا حكينا عنه وسميناه luteinization بعد
+
+66
+00:04:51,240 --> 00:04:56,560
+أربعين ساعة من الـ luteinization أصبحت تسمى
+
+67
+00:04:56,560 --> 00:05:01,460
+Granulosa Lutein Cells وإلها وظيفة معينة Beginning
+
+68
+00:05:01,460 --> 00:05:06,060
+secreting increasing amounts of progesterone along
+
+69
+00:05:06,060 --> 00:05:09,380
+with some estrogen إذن هذه الـ granulosa cells اللي
+
+70
+00:05:09,380 --> 00:05:13,740
+اتحولت إلى Granulosa Lutein Cells أصبحت تلعب دورا 
+
+71
+00:05:13,740 --> 00:05:19,400
+مهمة في إفراز كمية كبيرة وكافية من البروجسترون 
+
+72
+00:05:19,400 --> 00:05:23,510
+بالإضافة إلى كمية من الاستروجين والبروجسترون عرفنا 
+
+73
+00:05:23,510 --> 00:05:28,050
+في السابق أنه هرمون مهم جدا يساعد على بقاء الحمل
+
+74
+00:05:28,050 --> 00:05:31,750
+وعملية الـ implantation مهمة جدا عملية الـ 
+
+75
+00:05:31,750 --> 00:05:36,250
+implantation لأن بدونها بيصير عندي a portion in the
+
+76
+00:05:36,250 --> 00:05:39,810
+first trimester ولما نقول first trimester يعني أول 
+
+77
+00:05:39,810 --> 00:05:45,010
+ثلاثة شهور من عملية الحمل الـ granulosa lutein
+
+78
+00:05:45,010 --> 00:05:49,530
+cells are terminally differentiated يعني بتصير
+
+79
+00:05:49,530 --> 00:05:52,320
+لـ differentiated تنتهي عملية الـ
+
+80
+00:05:52,320 --> 00:05:56,760
+differentiation وتبقى كما هي في مبتعد بمجرد
+
+81
+00:05:56,760 --> 00:06:01,880
+انقسامها يتوقف أو توقف عملية الانقسام تتوقف خلاص
+
+82
+00:06:01,880 --> 00:06:05,260
+بمجرد تحويل الـ granulosa cells إلى granulosa الـ
+
+83
+00:06:05,260 --> 00:06:08,440
+lutein cells مافي انقسام بعد كده مافي 
+
+84
+00:06:08,440 --> 00:06:12,200
+differentiation توقفت جميع عمليات الانقسام وعمليات
+
+85
+00:06:12,200 --> 00:06:16,400
+التمييز المتعلقة بالـ granulosa cells بمجرد تحولها
+
+86
+00:06:16,400 --> 00:06:22,630
+إلى granulosa lutein cells بفعل luteinization but
+
+87
+00:06:22,630 --> 00:06:25,890
+they continue to secrete progesterone for 10
+
+88
+00:06:25,890 --> 00:06:29,350
+days طبعا مهمة جدا بيقولك صحيح ان اتحولت من 
+
+89
+00:06:29,350 --> 00:06:33,510
+granulosa cells لـ granulosa lutein cells واتوقفت من
+
+90
+00:06:33,510 --> 00:06:37,970
+الانقسام واتوقفت من التمايز يعني هتبقى كما هي ولكنها
+
+91
+00:06:37,970 --> 00:06:41,790
+تبقى تلعب دورا مهمة في إفراز الـ progesterone لمدة 
+
+92
+00:06:41,790 --> 00:06:46,650
+عشر أيام أو عشر أيام طب ليه؟ ببساطة جدا لإن خلال 
+
+93
+00:06:46,650 --> 00:06:50,450
+فترة العشر أيام يجب أن تتكوّن الـ placenta 
+
+94
+00:06:53,640 --> 00:06:58,320
+إفراز البروجيسترون منها وبالتالي يتوقف إفراز
+
+95
+00:06:58,320 --> 00:07:02,960
+البروجيسترون من الـ granulosa lutein cells قدت 
+
+96
+00:07:02,960 --> 00:07:06,400
+وظيفتها بعد عشر أيام خدوا بالك ليش بعد عشر أيام؟ 
+
+97
+00:07:06,400 --> 00:07:10,440
+لأن في فترة هذه يا إما بيصير pregnancy موجود وصار 
+
+98
+00:07:10,440 --> 00:07:13,120
+له implantation يا إما مافيه عندها pregnancy 
+
+99
+00:07:13,120 --> 00:07:18,740
+فبالتالي بيصير عندها menstrual cycle جديد The 
+
+100
+00:07:18,740 --> 00:07:21,960
+secretion of human chorionic gonadotropin اللي بتسمي
+
+101
+00:07:21,960 --> 00:07:26,060
+HCG يلعب دورا مهمة في عملية الـ Maintenance of 
+
+102
+00:07:26,060 --> 00:07:29,920
+Pregnancy until approximately the seventh week of
+
+103
+00:07:29,920 --> 00:07:35,100
+the pregnancy أو الـ gestation يعني بمعنى أخر أن 
+
+104
+00:07:35,100 --> 00:07:39,560
+الهرمون اللي سميته HCG وهو اختصار له Human Chorionic
+
+105
+00:07:39,560 --> 00:07:43,760
+Gonadotropin هذا مش هرمون عبث يفرز، لا هرمون مهم 
+
+106
+00:07:43,760 --> 00:07:50,060
+جدا يفرز بشكل مستمر ويلعب دورا أساسية ومهمة بجانب
+
+107
+00:07:50,060 --> 00:07:55,450
+البروجسترون في المحافظة على الحمل وبقاءه لمدة ما
+
+108
+00:07:55,450 --> 00:08:00,770
+يقارب سبع أسابيع لمدة أول سبع أسابيع من الحمل ما 
+
+109
+00:08:00,770 --> 00:08:04,010
+بين الأسبوع السابع للأسبوع العاشر من عملية الحمل
+
+110
+00:08:04,010 --> 00:08:08,230
+The Corpus Luteum is replaced by the placenta in
+
+111
+00:08:08,230 --> 00:08:14,530
+terms of progesterone production يعني بعد السبع
+
+112
+00:08:14,530 --> 00:08:19,290
+أسابيع وصولا للأسبوع العاشر البروجسترون يفقد 
+
+113
+00:08:24,490 --> 00:08:29,330
+يعني الـ Corpus Luteum تدريجيا يفقد قدرته على
+
+114
+00:08:29,330 --> 00:08:34,350
+إخراج وإفراز البروجسترون فمن سيحل محله؟ سيحل محله
+
+115
+00:08:34,350 --> 00:08:38,750
+الـ placenta اللي بدأ تتكون هذه الفترة عملية 
+
+116
+00:08:38,750 --> 00:08:41,110
+التحول وهذا الـ event اللي بتصير وهذا الطول اللي
+
+117
+00:08:41,110 --> 00:08:46,200
+بيصير هذه الفترة من عملية الـ Corpus Luteum Luteal Placenta
+
+118
+00:08:46,200 --> 00:08:50,420
+Shift ماهي المقصود فيها؟ بداية في أربع نقاط بسيطة
+
+119
+00:08:50,420 --> 00:08:54,300
+جدا granulosa cells اتحولت إلى granulosa lutein
+
+120
+00:08:54,300 --> 00:09:00,460
+cells قادرة على إفراز البروجسترون وكمية من الاستروجين
+
+121
+00:09:00,460 --> 00:09:05,320
+البروجسترون مهم جدا في إبقاء الحمل والمساعدة على
+
+122
+00:09:05,320 --> 00:09:11,360
+الـ implantation يبقى هذه العملية لمدة 7 أسابيع أول 7
+
+123
+00:09:11,360 --> 00:09:14,560
+أسابيع من عملية الحمل ما بين الأسبوع السابع
+
+124
+00:09:14,560 --> 00:09:18,080
+والعاشر تبدأ الـ placenta في التكون لكي تأخذ مكان 
+
+125
+00:09:18,080 --> 00:09:22,860
+الـ Corpus Luteum في إفراز البروجسترون بمجرد توقف
+
+126
+00:09:22,860 --> 00:09:27,340
+إفراز البروجسترون من الـ Corpus Luteum وإفرازه من 
+
+127
+00:09:27,340 --> 00:09:31,760
+الـ placenta هذه العملية بنسميها الـ Luteal Placental 
+
+128
+00:09:31,760 --> 00:09:37,850
+Shift بمعنى آخر Progesterone as a hormone بدل ما يُفرَز
+
+129
+00:09:37,850 --> 00:09:40,850
+من الـ Luteal granulosa lutein cells أصبح 
+
+130
+00:09:40,850 --> 00:09:45,230
+يُفرَز من الـ Placenta شيء كده يسموها Luteal الأصل
+
+131
+00:09:45,230 --> 00:09:50,690
+Placental الجديدة Shift من إلها In conception
+
+132
+00:09:50,690 --> 00:09:55,690
+cycle the life of the Corpus Luteum is extended
+
+133
+00:09:55,690 --> 00:09:58,570
+until the Luteal Placental Shift again يعني في
+
+134
+00:09:58,570 --> 00:10:02,230
+الوضع الطبيعي بقولك الـ Corpus Luteum يبقى متوفر
+
+135
+00:10:02,230 --> 00:10:08,390
+يبقى فعال يبقى يعمل على إفراج البروجسترون حتى تكوين
+
+136
+00:10:08,390 --> 00:10:11,790
+الـ placenta بمجرد تكوين الـ placenta يتوقف عن
+
+137
+00:10:11,790 --> 00:10:17,370
+عملية الإفراز يعني بمعنى آخر وبشكل منطقي المفروض 
+
+138
+00:10:17,370 --> 00:10:21,630
+يتوقف بشكل كامل عند الأسبوع العاشر ويبدأ بعد كده
+
+139
+00:10:21,630 --> 00:10:24,970
+في عملية الـ degradation أو الـ atrophy فده يعني
+
+140
+00:10:24,970 --> 00:10:29,410
+الـ Corpus Luteum in the absence of fertilization
+
+141
+00:10:29,410 --> 00:10:33,410
+ماصارش فيه fertilization and hormone stimulus
+
+142
+00:10:33,410 --> 00:10:37,340
+provided by the early embryo الـcorpus luteum يبدأ
+
+143
+00:10:37,340 --> 00:10:41,440
+بالتخصيب للبويضة والتخصيب للبويضة والتخصيب
+
+144
+00:10:41,440 --> 00:10:46,260
+للبويضة والتخصيب للبويضة والتخصيب للبويضة
+
+145
+00:10:46,260 --> 00:10:46,520
+والتخصيب للبويضة والتخصيب للبويضة والتخصيب
+
+146
+00:10:46,520 --> 00:10:48,260
+للبويضة والتخصيب للبويضة والتخصيب للبويضة
+
+147
+00:10:48,260 --> 00:10:49,540
+والتخصيب للبويضة والتخصيب للبويضة والتخصيب
+
+148
+00:10:49,540 --> 00:10:54,900
+للبويضة والتخصيب للبويضة والتخصيب للبويضة
+
+149
+00:10:54,900 --> 00:11:02,840
+والتخصيب للبويضة والتخصيب للبويضة والتخصيب
+
+150
+00:11:02,840 --> 00:11:12,290
+بالنسبة للبروجيسترون ستكون تنقص
+
+151
+00:11:12,290 --> 00:11:16,790
+بشكل تدريجي أو 
+
+152
+00:11:16,790 --> 00:11:19,370
+تنقص أو تدريجي أو تدريجي أو تدريجي أو تدريجي أو
+
+153
+00:11:19,370 --> 00:11:20,370
+تدريجي أو تدريجي أو تدريجي أو تدريجي أو تدريجي أو
+
+154
+00:11:20,370 --> 00:11:21,710
+تدريجي أو تدريجي أو تدريجي أو تدريجي أو تدريجي أو
+
+155
+00:11:21,710 --> 00:11:23,790
+تدريجي أو تدريجي أو تدريجي أو تدريجي أو تدريجي أو
+
+156
+00:11:23,790 --> 00:11:30,550
+تدريجي أو تدريجي أو تدريجي أو لأن مافي بلاستنتا
+
+157
+00:11:30,550 --> 00:11:35,390
+اتكونت فبالتالي بعد 8 أسابيع أو 10 أسابيع ما له 
+
+158
+00:11:35,390 --> 00:11:38,970
+function فبيصير له لوتيوليزيس اللي أنا حكيتها قبل
+
+159
+00:11:38,970 --> 00:11:43,030
+بشوية أو الـdegeneration طيب، this is necessary to
+
+160
+00:11:43,030 --> 00:11:45,510
+allow the development of a new follicle providing
+
+161
+00:11:45,510 --> 00:11:49,810
+a new chance for fertilization بمجرد أنه يبدأ
+
+162
+00:11:49,810 --> 00:11:53,590
+الـcorpus luteum في الـdegradation أو الـbreakdown هذا
+
+163
+00:11:53,590 --> 00:11:57,720
+بيعطي إشارة مباشرة إلى الـhypothalamus بعد ذلك إلى
+
+164
+00:11:57,720 --> 00:11:59,960
+الـanterior loop of the pituitary gland عشان تبدأ
+
+165
+00:11:59,960 --> 00:12:04,660
+دورة جديدة من إفراز الـFSH والـLH عشان يعطيني دورة
+
+166
+00:12:04,660 --> 00:12:09,140
+شهرية جديدة وعملية إباضة جديدة جديدة مما يسمح
+
+167
+00:12:09,140 --> 00:12:15,280
+بحدوث حمل مستقبلاً and it's okay by the 22 to 24
+
+168
+00:12:15,280 --> 00:12:19,140
+of menstrual cycle يعني بمعنى آخر أن هذه العملية و
+
+169
+00:12:19,140 --> 00:12:25,100
+هذه الـatrophy تبدأ بتصير في اليوم 22 لليوم 24 من
+
+170
+00:12:25,100 --> 00:12:29,520
+الدورة عشان تبدأ دورة جديدة تمامًا ما بيحدث إذا
+
+171
+00:12:29,520 --> 00:12:32,760
+ما صار fertilization يعني there is no pregnancy
+
+172
+00:12:32,760 --> 00:12:36,300
+خذوا
+
+173
+00:12:36,300 --> 00:12:40,360
+بالكم من الكلام مافي مشكلة بعد 7 أسابيع بيصيروا
+
+174
+00:12:40,360 --> 00:12:44,320
+تأثير فيه بعد 7 أسابيع هو فبتوقف خليني أسميه إذا 
+
+175
+00:12:44,320 --> 00:12:47,680
+جاز التعبير لأنه لبدأ سنة أخدت الكامل أكبر
+
+176
+00:12:50,310 --> 00:12:54,050
+خلاص فصار له reduction في الـfunctional limit هذا
+
+177
+00:12:54,050 --> 00:12:58,540
+يعني الـcorpus luteum لكن لو ما صار حمل ما في داعي 
+
+178
+00:12:58,540 --> 00:13:03,840
+أنه يستمر في إنتاج البروجيسترون عشان كده بتوقف و
+
+179
+00:13:03,840 --> 00:13:06,900
+ببدأ يدخل فيه الـdegeneration في اليوم 22 من
+
+180
+00:13:06,900 --> 00:13:10,400
+الدورة إذا المعلومة الأولى ما فيها تعارض في
+
+181
+00:13:10,400 --> 00:13:13,560
+المعلومة الثانية المعلومة الأولى تتعلق إذا صار
+
+182
+00:13:13,560 --> 00:13:16,720
+pregnancy المعلومة الثانية إذا ما صار pregnancy
+
+183
+00:13:16,720 --> 00:13:21,100
+تمام؟ تمام الـsecond phase the functional
+
+184
+00:13:33,860 --> 00:13:37,460
+مهم جدًا بعد ما يصير له الـDegeneration ويصير
+
+185
+00:13:37,460 --> 00:13:39,420
+Reduction عفواً، بعد ما يصير Reduction في
+
+186
+00:13:39,420 --> 00:13:42,640
+البروجيسترون ويبدأ يصير له Lutealization و
+
+187
+00:13:42,640 --> 00:13:46,420
+Degeneration لازم يصير Removing للـcorpus luteum
+
+188
+00:13:46,420 --> 00:13:49,920
+بشكل كامل علشان ما يصيرش Accumulation لأنه كده
+
+189
+00:13:49,920 --> 00:13:54,280
+بالكل كل دورة بيصير عندك Corpus Luteum Formation لأن
+
+190
+00:13:54,280 --> 00:13:58,340
+أصل الـCorpus Luteum هو عبارة عن Graafian
+
+191
+00:13:58,340 --> 00:14:01,420
+Follicle اللي بتطلع منها البويضة إذا كل عملية
+
+192
+00:14:01,420 --> 00:14:05,000
+إباضة وخروج بويضة في عندك Graafian Follicle تتحول
+
+193
+00:14:05,000 --> 00:14:09,160
+إلى Corpus Luteum تصور على مدار السنة في عندك مثلاً
+
+194
+00:14:09,160 --> 00:14:15,150
+على أقل تقدير 12 عملية إباضة، يعني 12 follicle،
+
+195
+00:14:15,150 --> 00:14:17,650
+يعني 12 corpus luteum إذا صار accumulation
+
+196
+00:14:17,650 --> 00:14:23,230
+لهذه الأنسجة مع بعض لبعض تؤدي إلى حدوث مشكلة في الـ
+
+197
+00:14:23,230 --> 00:14:27,490
+over it إحنا كـhuman في غنى عنها، إحنا كـhuman في
+
+198
+00:14:27,490 --> 00:14:30,630
+غنى عنها فبالتالي لازم يصير الـdegeneration و
+
+199
+00:14:30,630 --> 00:14:36,970
+removing للـcorpus luteum بشكل كامل removing الـcorpus
+
+200
+00:14:36,970 --> 00:14:42,110
+luteum بشكل تدريجي ولكن بياخد فترة زمنية طويلة
+
+201
+00:14:42,110 --> 00:14:45,450
+إلى حد ما مش طويلة يعني سنين لأ طويلة إلى حد ما
+
+202
+00:14:45,450 --> 00:14:48,710
+مقصود بالـcycle مش بعد كل cycle بروح وبنتي بده
+
+203
+00:14:48,710 --> 00:14:51,730
+اتنين ثلاث أربع cycle عشان ينتهي الأول corpus
+
+204
+00:14:51,730 --> 00:14:55,210
+luteum عشان كده بحكي لك أنه الـstructure
+
+205
+00:14:55,210 --> 00:14:58,230
+lutealized and its beginning after the degrees of
+
+206
+00:14:58,230 --> 00:15:01,810
+progesterone as we said secretion also complete
+
+207
+00:15:01,810 --> 00:15:04,750
+deletion of the corpus luteum should take
+
+208
+00:15:04,750 --> 00:15:08,370
+several cycle يعني ممكن بعد 20 cycle corpus
+
+209
+00:15:08,370 --> 00:15:12,250
+luteum يختفي الأول اللي اتكون هذه الفكرة المقصود
+
+210
+00:15:12,250 --> 00:15:17,250
+فيها يعني بمعنى آخر مش انتهاء الدورة وما في عملية
+
+211
+00:15:17,250 --> 00:15:20,770
+pregnancy ينتهي الـcorpus luteum بشكل فوري لأ
+
+212
+00:15:20,770 --> 00:15:24,090
+بياخد several cycle ممكن تكون خمسة، ستة، سبعة،
+
+213
+00:15:24,090 --> 00:15:29,590
+عشرة، بينها على طبيعة السيدة During the regeneration
+
+214
+00:15:29,590 --> 00:15:32,830
+of the corpus luteum, the granulosa lutein cell
+
+215
+00:15:32,830 --> 00:15:37,810
+degenerate and are replaced with collagenous scar
+
+216
+00:15:37,810 --> 00:15:40,770
+tissue خلال عملية الـdegeneration والـlysis،
+
+217
+00:15:40,770 --> 00:15:44,150
+الجرانولوزا سيل تتحول وتستبدل وتكسى
+
+218
+00:15:44,150 --> 00:15:48,110
+بالـcollagenous tissue لونها أبيض، عشان كده
+
+219
+00:15:48,110 --> 00:15:50,850
+الـcorpus luteum بتتحول من corpus luteum with
+
+220
+00:15:50,850 --> 00:15:55,050
+yellow color إلى corpus albicans with white color،
+
+221
+00:15:55,050 --> 00:15:59,300
+لأنه عبارة عن ألياف كل جيل والكل جيل دائماً أبيض
+
+222
+00:15:59,300 --> 00:16:03,720
+اللون لذلك corpus luteum في حالة شيخوخته خليني
+
+223
+00:16:03,720 --> 00:16:08,540
+أسميه أو توجهه إلى الـdegeneration phase بتحول من
+
+224
+00:16:08,540 --> 00:16:11,780
+اللون الأصفر إلى اللون الأبيض بسميه corpus luteum
+
+225
+00:16:11,780 --> 00:16:21,780
+2 corpus albicans ده السؤال المهم جداً فهمنا كيف تحدث
+
+226
+00:16:21,780 --> 00:16:25,580
+الـovulation فهمنا كيف تتحول الـgraafian follicle
+
+227
+00:16:25,580 --> 00:16:29,120
+إلى corpus luteum فهمنا متى يختفي الـcorpus
+
+228
+00:16:29,120 --> 00:16:33,760
+luteum سواء كان في الـcase pregnant أو non
+
+229
+00:16:33,760 --> 00:16:37,320
+-pregnant شو بيحصل في الـfertilization؟ وشو هي الـ
+
+230
+00:16:37,320 --> 00:16:40,500
+fertilization؟ وأين بتحصل الـfertilization؟ الـ
+
+231
+00:16:40,500 --> 00:16:44,120
+fertilization ببساطة جدا هي عملية تحدث عند لقاء
+
+232
+00:16:44,120 --> 00:16:50,830
+الجاميطات The process should be occur when gamete face to
+
+233
+00:16:50,830 --> 00:16:54,370
+face يعني الجاميطات بتبقى face to face علشان يصير في
+
+234
+00:16:54,370 --> 00:16:57,990
+coupling ما بينهم أو joint ما بينهم إيش يعني
+
+235
+00:16:57,990 --> 00:17:00,510
+coupling وإيش يعني joint؟ مش coupling بالشكل
+
+236
+00:17:00,510 --> 00:17:04,030
+المتعارف أو الشكل المتوقع ولكن هي عبارة عن
+
+237
+00:17:04,030 --> 00:17:07,310
+penetration للسّبيرم الـoocyte يحدث لها
+
+238
+00:17:07,310 --> 00:17:11,970
+penetration بواسطّة السّبيرم only one single sperm أي
+
+239
+00:17:11,970 --> 00:17:15,130
+بويضة تخصب بـtwo sperm إن حدث بيصير لها
+
+240
+00:17:15,130 --> 00:17:18,330
+degeneration مباشرة إن حدث بيصير لها degeneration
+
+241
+00:17:18,330 --> 00:17:22,620
+مباشرة اتفقنا؟ اتفقنا When spermatozoa started to
+
+242
+00:17:22,620 --> 00:17:26,300
+penetrate the corona radiata that surrounding the
+
+243
+00:17:26,300 --> 00:17:32,000
+egg and end with the invasion of the maternal and
+
+244
+00:17:32,000 --> 00:17:35,580
+paternal chromosomes after spermatozoa has entered
+
+245
+00:17:35,580 --> 00:17:38,860
+the egg يعني هي عبارة عن عملية تبدأ باقتراب الـ
+
+246
+00:17:38,860 --> 00:17:42,420
+sperm الـmale gametes من الـfemale gametes الـ
+
+247
+00:17:42,420 --> 00:17:45,930
+oocyte يبدأ الـsperm باختراق الـcorona radiata
+
+248
+00:17:45,930 --> 00:17:51,450
+الطبقة المحيطة بها ثم الـzona pellucida ثم تندمج
+
+249
+00:17:51,450 --> 00:17:54,210
+المادة الوراثية الخاصة بالـmaternal بالمادة
+
+250
+00:17:54,210 --> 00:17:58,110
+الوراثية الخاصة بالـpaternal اندماجًا كاملًا من
+
+251
+00:17:58,110 --> 00:18:02,990
+حصول نواة واحدة هنا بسميها fertilized oocyte
+
+252
+00:18:02,990 --> 00:18:08,550
+fertilized oocyte يعني بويضة مخصبة الـcorona
+
+253
+00:18:08,550 --> 00:18:12,790
+radiata هي عبارة عن خلايا تحيط بالـoocyte with a
+
+254
+00:18:12,790 --> 00:18:16,410
+high cellular layer with an intracellular matrix
+
+255
+00:18:16,410 --> 00:18:19,370
+consist of يعني هي عبارة عن خلايا محيطة بالـ
+
+256
+00:18:19,370 --> 00:18:22,170
+oocyte من الخارج ولكن الـmatrix في الداخل التابع
+
+257
+00:18:22,170 --> 00:18:29,450
+الخاص بها يحتوي على مواد أخرى البروتينات بشكل أساسي
+
+258
+00:18:29,450 --> 00:18:33,990
+بـhigh concentration of carbohydrate and
+
+259
+00:18:33,990 --> 00:18:37,610
+hyaluronic acid خذوا بالكم المواد هذه مهمة جدا لازم
+
+260
+00:18:37,610 --> 00:18:41,450
+تكون فيها لأنها بتغذي البويضة بشكل أساسي في المراحل
+
+261
+00:18:41,450 --> 00:18:45,850
+الأولى من عملية النضج It is why believed
+
+262
+00:18:45,850 --> 00:18:51,910
+that hyaluronidase present
+
+263
+00:18:51,910 --> 00:18:56,050
+or released from the head of a sperm play a very
+
+264
+00:18:56,050 --> 00:19:00,390
+important role وبين تريدت كورونا ردياتا طالما أن
+
+265
+00:19:00,390 --> 00:19:03,490
+كورونا ردياتا هذه الخلية فيها مركب اسمه الهيالورنك
+
+266
+00:19:03,490 --> 00:19:08,470
+أسيد طبيعي ومنطقي يجب أن يكون في الـsperm head
+
+267
+00:19:08,470 --> 00:19:12,390
+إنزيم يكسر هذه المادة لماذا هذه المادة موجودة؟
+
+268
+00:19:12,390 --> 00:19:15,870
+أو لماذا هذه المادة موجودة؟ الهيالورنك أسيد الموجود
+
+269
+00:19:15,870 --> 00:19:19,210
+في كورونا ردياتا بحافظ على تماسك الخلايا حول
+
+270
+00:19:19,210 --> 00:19:23,210
+البويضة عشان الـsperm يخترق هذا التماسك البنيان
+
+271
+00:19:23,210 --> 00:19:27,610
+المرسوم حول البويضة لازم يعمل تكسير في هذا البنيان
+
+272
+00:19:27,610 --> 00:19:31,830
+أو تكسير في المادة الموجودة فبيفرز الـhead sperm
+
+273
+00:19:31,830 --> 00:19:37,050
+بيحتوي على vesicles تفرز إنزيم بيشتغل ضد الـ
+
+274
+00:19:37,050 --> 00:19:41,050
+hyaluronic acid اسمه hyaluronidase enzyme بيعمل
+
+275
+00:19:41,050 --> 00:19:46,070
+breakdown for this complex فبيساعد الـsperm على
+
+276
+00:19:46,070 --> 00:19:51,800
+اختراق البويضة من خلال اختراق الـcorona radiata but
+
+277
+00:19:51,800 --> 00:19:55,000
+the active swimming movement of the sperm are also
+
+278
+00:19:55,000 --> 00:19:58,860
+important هل يعني أن الـsperm يستطيع اختراق
+
+279
+00:19:58,860 --> 00:20:04,360
+البويضة من خلال إفراز المادة اللي سميتها هيالورونيد من
+
+280
+00:20:04,360 --> 00:20:09,760
+خلال إفراز المادة التي تعمل على الهيالورنك أسيد؟ لأ 
+
+281
+00:20:09,760 --> 00:20:13,400
+صح هي بتلعب دور أساسي ولكن لازم plus  the movement
+
+282
+00:20:13,400 --> 00:20:17,400
+وحنشوفها كمان شوية تحت انوار الـ activation 
+
+283
+00:20:17,400 --> 00:20:21,020
+the movement هنشوفها بشرحها و نسمعها و نشوفها في فيديو
+
+284
+00:20:21,020 --> 00:20:24,340
+إن شاء الله إذا عملية الـ penetration تعتمد على
+
+285
+00:20:24,340 --> 00:20:28,180
+نقطتين أساسيتين: إفراز إنزيم يعمل على الـ Hyaluronic acid
+
+286
+00:20:28,180 --> 00:20:34,640
+الـ Hyaluronic acid بيشتغل عليه و الـ movement اللي تحدث
+
+287
+00:20:34,640 --> 00:20:37,480
+في الـ sperm من خلال الـ swimming من خلال الـ
+
+288
+00:20:37,480 --> 00:20:45,420
+swimming  يخترق الـ sperm الـ corona radiata بعد كده 
+
+289
+00:20:45,420 --> 00:20:50,890
+لازم يواجه الحائط الآخر أو المانع الآخر اللي جاي من
+
+290
+00:20:50,890 --> 00:20:54,710
+يصل للمادة الوراثية اللي خاصة بالبويضة، وهذا المانع
+
+291
+00:20:54,710 --> 00:21:00,490
+يسمى Zona pellucida، وهو عبارة عن  Zona pellucida، so the sperm
+
+292
+00:21:00,490 --> 00:21:04,090
+should be penetrated the Zona pellucida after
+
+293
+00:21:04,090 --> 00:21:07,660
+attachment with the receptor The Outer Surface of
+
+294
+00:21:07,660 --> 00:21:12,100
+Zona pellucida وفي ريسيبتور على الـ Oocyte أكيد في
+
+295
+00:21:12,100 --> 00:21:14,860
+ريسيبتور، و لا كيف بتصير فيه أنه عندي نوع من أنواع
+
+296
+00:21:14,860 --> 00:21:19,080
+التخصصية أو الخصوصية الـ specificity كيف بتصير و
+
+297
+00:21:19,080 --> 00:21:25,520
+إلا ممكن أحط نطف الحيوان مثلا بوايض الطائر نطف
+
+298
+00:21:25,520 --> 00:21:29,020
+خاصة بطائر معين أو بحيوان معين، وهذا شيء غير
+
+299
+00:21:29,020 --> 00:21:33,960
+منطقي، فبالتالي في ريسيبتور مهم جدا علشان يصير في 
+
+300
+00:21:33,960 --> 00:21:37,730
+عندي Attachment ثم Penetration ثم Fertilization
+
+301
+00:21:37,730 --> 00:21:44,430
+Zona pellucida  سماكتها يقدر بحوالي 13 ميكرومتر، تبعد
+
+302
+00:21:44,430 --> 00:21:49,650
+خاصة بـ human female oocyte تتكون من جليكوبروتين
+
+303
+00:21:49,650 --> 00:21:55,670
+بشكل أساسي، تقسم إلى Zona pellucida 1,2,3,4، جمعها 
+
+304
+00:21:55,670 --> 00:21:59,930
+مع بعضها لتصميم جزء أساسي من الـ polymerized into
+
+305
+00:21:59,930 --> 00:22:03,720
+long filamentيعني هذه ترتبط مع بعضها البعض عشان
+
+306
+00:22:03,720 --> 00:22:07,900
+تديني الـ Zona pellucida الكاملة المتعرف عليها طبعا
+
+307
+00:22:07,900 --> 00:22:11,820
+بعد ما يصير اختراق للـ corona radiata بفعل الـ
+
+308
+00:22:11,820 --> 00:22:16,100
+sperm، الـ sperm مباشرة بعمل search على الـ 
+
+309
+00:22:16,100 --> 00:22:22,200
+receptor و بتتصل مع الـ Zona pellucida من خلال الـ
+
+310
+00:22:22,200 --> 00:22:25,860
+receptor، الـ Zona pellucida by mean of the plasma
+
+311
+00:22:25,860 --> 00:22:29,830
+membrane of the sperm head Spermatozoa binds
+
+312
+00:22:29,830 --> 00:22:34,170
+specifically to the sialic acid molecule that is
+
+313
+00:22:34,170 --> 00:22:37,170
+attached with the polypeptide core of the
+
+314
+00:22:37,170 --> 00:22:41,130
+Zona pellucida molecule بمعنى آخر أنه عشان يصير
+
+315
+00:22:41,130 --> 00:22:45,230
+penetration للـ Oocyte أو للـ Zona pellucida لازم ال
+
+316
+00:22:45,230 --> 00:22:50,870
+sperm ينسك في منطقة معينة لا تتواجد إلا في الـ
+
+317
+00:22:50,870 --> 00:22:55,250
+Zona pellucida 3، تسمى الـ sialic acid molecule يعني
+
+318
+00:22:55,250 --> 00:23:01,490
+كأن الـ sperm متخصص بالارتباط بالـ sialic acid
+
+319
+00:23:01,490 --> 00:23:09,270
+molecule الموجود في Zona pellucida 3 والذي مرتبط
+
+320
+00:23:09,270 --> 00:23:11,570
+بالـ polypeptide core of Zona pellucida 3 بشكل
+
+321
+00:23:11,570 --> 00:23:16,180
+أساسيبشكل أساسي موجودة في أو مرتبط بهذا الـ Silic
+
+322
+00:23:16,180 --> 00:23:20,480
+Acid في الـ Poly-Tied Core of Zona pellucida-3
+
+323
+00:23:20,480 --> 00:23:24,520
+موليول on the surface of sperm head are specific
+
+324
+00:23:24,520 --> 00:23:28,160
+binding site of Zona pellucida-3 sperm receptor on
+
+325
+00:23:28,160 --> 00:23:31,640
+the Zona pellucida So what is the meaning of this
+
+326
+00:23:31,640 --> 00:23:38,530
+paragraph؟ ببساطة إن الـ sperm بيبحث عن منطقة في
+
+327
+00:23:38,530 --> 00:23:41,910
+الـ Zona pellucida 3 فقط، لغير هي عبارة عن الـ
+
+328
+00:23:41,910 --> 00:23:45,930
+Receptor لأنها تحتوي على مادة يختص فيها ولا يتعرف
+
+329
+00:23:45,930 --> 00:23:49,870
+إلا عليها لـ sperm مثلا تسمى Sialic Acid، هذا الـ
+
+330
+00:23:49,870 --> 00:23:52,890
+Sialic Acid الـ attachment و الـ polypeptide core
+
+331
+00:23:52,890 --> 00:23:56,100
+الموجود في الـ Zona pellucida يعني تشتغل هذه المنطقة
+
+332
+00:23:56,100 --> 00:24:01,220
+كـ Receptor وهي موجودة هيرقبط فيها ب sperm تمهيدة
+
+333
+00:24:01,220 --> 00:24:06,540
+لعملية إفراز الإنزيمات الهاضمة للـ Zona pellucida
+
+334
+00:24:06,540 --> 00:24:11,840
+طيب، before binding to the Zona pellucida  مباشرة
+
+335
+00:24:11,840 --> 00:24:15,100
+الـ spermatozoa undergo to a  capacitation reaction
+
+336
+00:24:15,100 --> 00:24:21,250
+طبعا قبل ما يتم الإرتباط وقبل ما يصل إلى الـ
+
+337
+00:24:21,250 --> 00:24:24,650
+receptor ويصير فيه إرتباط بشكل واضح وقوي، لازم
+
+338
+00:24:24,650 --> 00:24:28,830
+يصير عند الـ sperm full active و عشان يصير الـ
+
+339
+00:24:28,830 --> 00:24:33,530
+sperm full active يعني لازم يكون قادر على إفراز
+
+340
+00:24:33,530 --> 00:24:38,740
+الإنزيمات الهاضمة، تحت مصطلح الـ acrosomal reaction، يبقى
+
+341
+00:24:38,740 --> 00:24:41,160
+شو بيصير في الـ acrosomal reaction؟ و شو هو الـ
+
+342
+00:24:41,160 --> 00:24:43,840
+acrosomal reaction؟ الـ acrosomal reaction سلسلة
+
+343
+00:24:43,840 --> 00:24:47,020
+من التفاعلات بتصير على الـ acrosome الموجود في
+
+344
+00:24:47,020 --> 00:24:51,800
+مقدمة الـ head للـ sperm تمهيدا لإفراز محتويات الـ
+
+345
+00:24:51,800 --> 00:24:56,120
+acrosome التي تحتوي على الإنزيمات الهاضمة كيف
+
+346
+00:24:56,120 --> 00:25:00,780
+تبدأ؟ في البداية في بداية تطور الـ acrosome
+
+347
+00:25:00,780 --> 00:25:04,740
+reaction بيصير في عندي حاجة بيسموها massive influx
+
+348
+00:25:04,740 --> 00:25:07,100
+of calcium شو يعني massive؟ يعني  كبير، with ATP
+
+349
+00:25:07,100 --> 00:25:11,620
+influx خروج، تدفق، يعني كأنه الكالسيوم الموجود في
+
+350
+00:25:11,620 --> 00:25:14,360
+الـ head of the sperm أو الموجود في الـ acrosome
+
+351
+00:25:14,360 --> 00:25:22,280
+يخرج نحو الخارج بشكل تلقائي Ca+2 through the
+
+352
+00:25:22,280 --> 00:25:26,410
+plasma membrane of the sperm head هذا البروسيس اللي
+
+353
+00:25:26,410 --> 00:25:30,570
+مقصود فيه influx أو influx كبير من الكالسيوم من
+
+354
+00:25:30,570 --> 00:25:36,630
+جهة داخل الـ acrosome بيكون مصاحبه مباشرة influx للسوديوم و
+
+355
+00:25:36,630 --> 00:25:40,690
+efflux للهيدروجين، يعني كأنه مجرد ما يبدأ الـ
+
+356
+00:25:40,690 --> 00:25:47,180
+reaction الكالسيوم هيطلع من جهة الـ acrosome هيطلع معه
+
+357
+00:25:47,180 --> 00:25:51,760
+السوديوم، بينما الهيدروجين هيدخل داخل الـ head of 
+
+358
+00:25:51,760 --> 00:25:57,560
+sperm، الخروج والتدفق influx والدخول efflux هذا
+
+359
+00:25:57,560 --> 00:26:01,600
+بيعمل increasing للـ intracellular pH this process
+
+360
+00:26:01,600 --> 00:26:06,780
+caused exocytosis of the acrosomal vesicle هذه
+
+361
+00:26:06,780 --> 00:26:09,580
+مهمة جدا، خروج الكالسيوم، خروج الصوديوم ودخول
+
+362
+00:26:09,580 --> 00:26:13,040
+الهيدروجين بيعمل زيادة في الـ intracellular pH بيقرش
+
+363
+00:26:13,040 --> 00:26:17,500
+الخاصة بالـ sperm مما يسمح ويسبب عيب نسميه
+
+364
+00:26:17,500 --> 00:26:22,360
+Exocytosis، Exocytosis of acrosome vesicles يعني
+
+365
+00:26:22,360 --> 00:26:25,440
+خروج الـ acrosome في الـ vesicles، خدوا بالك، اندو
+
+366
+00:26:25,440 --> 00:26:30,240
+تختلف عن إندو، إندو للداخل، إكزو للخارج، لأنه لازم
+
+367
+00:26:30,240 --> 00:26:33,900
+تطلع هذه الـ vesicles عشان تفرز محتوى عشان تدمر
+
+368
+00:26:33,900 --> 00:26:41,050
+الحواجز التي تمنعها من الوصول إلى البويضة، طبعا هذا
+
+369
+00:26:41,050 --> 00:26:49,870
+الوضع في إطلاق مجموعة من الإنزيمات الـ lytic enzymes
+
+370
+00:26:49,870 --> 00:26:51,290
+الـ lytic enzymes الـ lytic enzymes الـ lytic enzymes
+
+371
+00:26:51,290 --> 00:26:51,870
+الـ lytic enzymes الـ lytic enzymes الـ lytic enzymes
+
+372
+00:26:51,870 --> 00:26:53,050
+الـ lytic enzymes الـ lytic enzymes الـ lytic enzymes
+
+373
+00:26:53,050 --> 00:26:53,510
+الـ lytic enzymes الـ lytic enzymes الـ lytic enzymes
+
+374
+00:26:53,510 --> 00:26:54,510
+الـ lytic enzymes الـ lytic enzymes الـ lytic enzymes
+
+375
+00:26:54,510 --> 00:26:54,850
+الـ lytic enzymes الـ lytic enzymes الـ lytic enzymes
+
+376
+00:26:54,850 --> 00:26:57,750
+الـ lytic enzymes الـ lytic enzymes الـ lytic enzymes
+
+377
+00:26:57,750 --> 00:27:07,770
+الـ lytic enzymes الـ lytic enzymes الـ lytic enzymes
+
+378
+00:27:07,770 --> 00:27:12,820
+إفراز محتويات الـ acrosome اللي بنسميها
+
+379
+00:27:12,820 --> 00:27:16,280
+lytic enzyme أو degradative enzyme أو licensed
+
+380
+00:27:16,280 --> 00:27:20,840
+enzyme، يعني الإنزيمات الهاضمة بشكل أساسي، فبالتالي
+
+381
+00:27:20,840 --> 00:27:25,960
+مهم جدا أن تصير هذه العمليات علشان تبدأ ويبدأ ال
+
+382
+00:27:25,960 --> 00:27:30,880
+acrosome أن يفرز محتواه، ماهي محتوياته؟ licensed
+
+383
+00:27:30,880 --> 00:27:34,240
+enzyme أو lytic enzyme Penetration of the Zona
+
+384
+00:27:34,240 --> 00:27:41,230
+pellucida بتصير بطريقتين، الطريقة الأولى هي
+
+385
+00:27:41,230 --> 00:27:44,470
+إفراز الإنزيمات، الطريقة الثانية هي عبارة عن الـ
+
+386
+00:27:44,470 --> 00:27:47,090
+high active motility للـ sperm اللي بنسميها
+
+387
+00:27:47,090 --> 00:27:50,270
+hyperactivation .. hyperactivation .. هنشوفها و
+
+388
+00:27:50,270 --> 00:27:54,810
+اتكلمنا عنها في المحاضرة السابقة، أشهر الإنزيمات التي
+
+389
+00:27:54,810 --> 00:28:00,150
+تُفرَز خلال عملية الـ acrosome reaction هو إنزيم
+
+390
+00:28:00,150 --> 00:28:04,760
+بنسميه الـ acrosin، الـ Acrosin هو عبارة عن a serine
+
+391
+00:28:04,760 --> 00:28:08,440
+proteinase that is formed to the inner acrosome
+
+392
+00:28:08,440 --> 00:28:11,540
+membrane، هو عبارة عن بروتينيز، عشان كده بسميه
+
+393
+00:28:11,540 --> 00:28:15,180
+Acrosin، هو بروتينيز، إنزيم يحتوي على الـ Serine
+
+394
+00:28:15,180 --> 00:28:19,140
+موجود في الـ acrosome membrane، ومهم جدا في عملية
+
+395
+00:28:19,140 --> 00:28:22,140
+.. مرتبط في inner surface of acrosome membrane
+
+396
+00:28:22,140 --> 00:28:26,520
+ومهم جدا في عملية الـ penetration، الـ Acrosin هل له
+
+397
+00:28:26,520 --> 00:28:31,040
+معلومات أخرى، تعريف آخر، مواصفات أخرى؟ بهمني برو
+
+398
+00:28:31,040 --> 00:28:36,320
+أكروزين عبارة عن endoprotease enzyme، هو عبارة عن
+
+399
+00:28:36,320 --> 00:28:39,580
+endoprotease enzyme with trypsin-like for example
+
+400
+00:28:39,580 --> 00:28:44,420
+بيكون localized في الـ acrosome، الـ
+
+401
+00:28:44,420 --> 00:28:47,380
+enzymatic activity تبعته بيكون inactive
+
+402
+00:28:47,380 --> 00:28:50,940
+طالما هو داخل الـ acrosome بيكون inactive على شكل
+
+403
+00:28:50,940 --> 00:28:57,260
+زيموجين، بروأكروزين، بمجرد ما يتحول ويتنشط بتتحول
+
+404
+00:28:57,260 --> 00:29:00,710
+من البروأكروزين inactive form أو زي ما هو موجود in
+
+405
+00:29:00,710 --> 00:29:06,650
+active form إلى أكروزين في الـ active form أو بيبدأ
+
+406
+00:29:06,650 --> 00:29:09,930
+الـ action تبعه، مهم جدا يكون داخل الـ acrosome
+
+407
+00:29:09,930 --> 00:29:12,970
+الخاصة بالـ chromosome inactive علشان ما يعمل side
+
+408
+00:29:12,970 --> 00:29:19,470
+effect خلال عمل وتطور الـ sperm، هذه فكرة أو طريقة
+
+409
+00:29:19,470 --> 00:29:26,540
+شغل الأكروزين as a lytic enzyme صورة بتوضح الـ
+
+410
+00:29:26,540 --> 00:29:30,220
+events اللي ممكن تصير خلال الـ fertilization هي في
+
+411
+00:29:30,220 --> 00:29:35,380
+عندي الـ oocyte هي في عندي الـ sperm، الـ sperm makes
+
+412
+00:29:35,380 --> 00:29:39,120
+contact with egg الخطوة الأولى الـ acrosome طبعا
+
+413
+00:29:39,120 --> 00:29:42,080
+قولناها دي باللون الأخضر اللي بتكون دايما في مقدمة
+
+414
+00:29:42,080 --> 00:29:47,380
+رأس النطفة الذكرية الـ event رقم اتنين إن ال
+
+415
+00:29:47,380 --> 00:29:50,720
+acrosome react with Zona pellucida من خلال
+
+416
+00:29:50,720 --> 00:29:53,640
+Zona pellucida رقم تلاتة فبيفرز الـ lytic enzyme اللي
+
+417
+00:29:53,640 --> 00:29:57,910
+بتعمل على التدمير، يعني كأنه بيعمل عملية opening أو
+
+418
+00:29:57,910 --> 00:30:01,050
+holes في الـ Zona pellucida، ده الـ acrosome reacts
+
+419
+00:30:01,050 --> 00:30:07,370
+with perivitelline space يعني هذا الـ space اللي احنا
+
+420
+00:30:07,370 --> 00:30:11,370
+شايفينه هذا الـ space لونه زي لون الزهر الفاتح 
+
+421
+00:30:11,370 --> 00:30:16,610
+بنتسميه pre-vital space طبعا هنا هيلاقي granules
+
+422
+00:30:16,610 --> 00:30:20,250
+بسيطة بنتسميها protein receptor هذا هيتصل فيها لـ
+
+423
+00:30:20,250 --> 00:30:24,340
+the plasma membrane of sperm and egg تبدأ تعمل
+
+424
+00:30:24,340 --> 00:30:27,580
+fusion مع بعض من البعض وبتدخل بس النواة الخاصة
+
+425
+00:30:27,580 --> 00:30:32,260
+بالـ sperm يعني بمعنى آخر النواة الخاصة بالـ sperm
+
+426
+00:30:32,260 --> 00:30:35,420
+هي التي تشارك في عملية ال fertilization كمان شوية،
+
+427
+00:30:35,420 --> 00:30:38,540
+حلاج الكلام يختلف، حلاج النواة والـ mitochondria،
+
+428
+00:30:38,540 --> 00:30:44,320
+ويلها تفاصيل تانية خلّيني أشوف الفيديو اللي بتكلم
+
+429
+00:30:44,320 --> 00:30:49,000
+عن عملية ال fertilization وقريتها وأهم ال events
+
+430
+00:30:49,000 --> 00:30:50,280
+اللي ممكن تحصل خلالها
+
+431
+00:30:57,290 --> 00:31:01,210
+عندما يحدث الهجوم خلال التجارب، يتم دفع ما يقارب
+
+432
+00:31:01,210 --> 00:31:07,470
+200 مليون سبرم أو spermatozoa إلى الجلد. هم
+
+433
+00:31:07,470 --> 00:31:10,090
+يسافرون من خلال عصرهم، ويحركوا من خلال حركتين مثل
+
+434
+00:31:10,090 --> 00:31:14,850
+الـ whip أو الـ flagella، ومن ثم تدفعهم من خلال
+
+435
+00:31:14,850 --> 00:31:17,830
+عضلة العضلة العضلة العضلة العضلة العضلة العضلة العضلة العضلة 
+
+436
+00:31:17,830 --> 00:31:18,530
+عضلة عضلة عضلة عضلة عضلة عضلة عضلة عضلة عضلة عضلة
+
+437
+00:31:18,530 --> 00:31:19,170
+عضلة عضلة عضلة عضلة عضلة عضلة عضلة عضلة عضلة عضلة
+
+438
+00:31:19,170 --> 00:31:24,710
+عضلة عضلة عضلة عضلة عضلة عضلة 
+
+439
+00:31:24,710 --> 00:31:28,670
+عضلة عضلة عضلة عضلة عضلة عضلة قبل 200 سبيرمتازوه فقط
+
+440
+00:31:28,670 --> 00:31:32,810
+ستصل إلى الـ secondary oocyte في البرمجل ومن هذه
+
+441
+00:31:32,810 --> 00:31:37,090
+فقط واحدة سوف تفردلها الفرداليزية لا يمكن أن تحدث
+
+442
+00:31:37,090 --> 00:31:42,870
+حتى أن اتجهت اتجاهين كتابة واتجاه الاكراسومال
+
+443
+00:31:42,870 --> 00:31:48,470
+يمكن أن تأخذ ساعات كتابة واتجاه الاكراسومال لا
+
+444
+00:31:48,470 --> 00:31:53,920
+يمكن أن تأخذ ساعات ولكن تحريكات من الجدران والجدران
+
+445
+00:31:53,920 --> 00:31:58,220
+التجاري تحرير ممكنات البلازما اللي تقع في جدران
+
+446
+00:31:58,220 --> 00:32:03,280
+السبيرمتازوة أو الـ Acrosome تتسبب في الممكنات تصبح
+
+447
+00:32:03,280 --> 00:32:07,420
+أكثر مطرقة، وهذا يساعد في تحريك السبيرمتازوة لأحداث
+
+448
+00:32:07,420 --> 00:32:13,360
+الترتيب السبيرمتازوة تصبح حيبر أكثر، فالجسدها تضرب
+
+449
+00:32:13,360 --> 00:32:18,220
+أكثر بشكل عادي، ومصادرها تتحرك من الجهد الـ
+
+450
+00:32:18,220 --> 00:32:20,880
+Capacitated Spermatozoa تتحرك من خلال كورونا
+
+451
+00:32:20,880 --> 00:32:22,780
+راديايدا، عبارة عن عبارة عن عبارة عن عبارة عن
+
+452
+00:32:22,780 --> 00:32:24,000
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+453
+00:32:24,000 --> 00:32:24,620
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+454
+00:32:24,620 --> 00:32:25,480
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+455
+00:32:25,480 --> 00:32:25,700
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+456
+00:32:25,700 --> 00:32:25,880
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+457
+00:32:25,880 --> 00:32:27,700
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+458
+00:32:27,700 --> 00:32:45,140
+عبارة عن عبارة 
+
+459
+00:32:46,040 --> 00:32:51,240
+عندما يتم إطلاق مصادر الأنزيمات للـ Acrosome هذه
+
+460
+00:32:51,240 --> 00:32:54,180
+الأنزيمات ساعدت في تجهيز طريقة من خلال الـ
+
+461
+00:32:54,180 --> 00:32:57,460
+Zona pellucida يسمح بشركة الـ Spermatozoa بإدخال
+
+462
+00:32:57,460 --> 00:33:01,700
+مخطط الـ Perivitalin وتصل إلى مصادر الـ Plasma من
+
+463
+00:33:01,700 --> 00:33:05,920
+مصادر الـ Oocyte الثانوية التي تتعامل معها لتأكيد
+
+464
+00:33:05,920 --> 00:33:08,660
+أن فقط واحد من الـ Spermatozoa يدخل مصادر الـ
+
+465
+00:33:08,660 --> 00:33:13,410
+Zona pellucida ويتعامل مع مصادر الـ Oocyte Fusion of
+
+466
+00:33:13,410 --> 00:33:16,570
+the spermatozoan and oocyte membranes activates a
+
+467
+00:33:16,570 --> 00:33:21,090
+fast and a slow block to polyspermy. During fast
+
+468
+00:33:21,090 --> 00:33:24,450
+block to polyspermy, after fusion, the oocyte
+
+469
+00:33:24,450 --> 00:33:28,530
+membrane depolarizes, preventing other spermatozoa
+
+470
+00:33:28,530 --> 00:33:34,150
+from fusing with it. slow طبعا هنا بتكلم ما هي
+
+471
+00:33:34,150 --> 00:33:38,410
+الآلية التي تستخدمها البويضة لمنع قلقيها بأكثر من
+
+472
+00:33:38,410 --> 00:33:43,160
+سبقين وهذا هنشرحه كمان شوية والمجلد لـ Polyspermia
+
+473
+00:33:43,160 --> 00:33:48,400
+هو أيضًا مدفع من هذا الانتقال. في مجلد مدفع لـ
+
+474
+00:33:48,400 --> 00:33:51,840
+Polyspermia، يتم إطلاق حوار من الكالسيوم
+
+475
+00:33:51,840 --> 00:33:56,260
+الانتقالية، يسبب فيها عصباء صغيرة وكورتقالات تحت
+
+476
+00:33:56,260 --> 00:34:00,300
+عصباء الـ Oocyte Membrane لإطلاق مواصلتهم، يجعل
+
+477
+00:34:00,300 --> 00:34:05,100
+الـ ZP3 غير مفتوح ويجعل الـ Zona pellucida غير مدفع.
+
+478
+00:34:05,680 --> 00:34:09,180
+عندما يدخل الـ spermatozoon، يتعامل الـ Oocyte
+
+479
+00:34:09,180 --> 00:34:16,940
+Meiosis 2 ويتطور إلى الـ female pronucleus في هذه
+
+480
+00:34:16,940 --> 00:34:21,060
+الوقت، الـ sperm يتطور إلى الـ male pronucleus وال
+
+481
+00:34:21,060 --> 00:34:25,680
+the two pronuclei يتجمدوا لتصميم نوكليس ديبلويد أو
+
+482
+00:34:25,680 --> 00:34:30,820
+zygote طبعا
+
+483
+00:34:30,820 --> 00:34:37,120
+هنا اتكلم عن أكثر من حالة على سبيل المثال، اتكلم
+
+484
+00:34:37,120 --> 00:34:40,840
+عن الآلية التي يتم في عملية ال penetration دور الـ 
+
+485
+00:34:40,840 --> 00:34:47,960
+ZP3 الموجودة بالوسداء كيف الـ oocyte تمنع التوقيع
+
+486
+00:34:47,960 --> 00:34:52,120
+نفسها بأكثر من sperm من خلال إفراز بعض المركبات
+
+487
+00:34:52,120 --> 00:34:57,620
+كيف يتكون الزيجوت أيضًا طبعًا عملية منع التوقيع بـ
+
+488
+00:34:57,620 --> 00:35:01,340
+two sperm لها طريقتين سنتحدث عنهم واحدة سلوك واحدة
+
+489
+00:35:01,340 --> 00:35:05,640
+فصل سأشرحهم في الفيديو بشكل مقتصر وسنتحدث عنهم إن
+
+490
+00:35:05,640 --> 00:35:08,920
+شاء الله طبعًا
+
+491
+00:35:10,340 --> 00:35:18,520
+بعد اتفاق الـ Spermatozoa الوراثية
+
+492
+00:35:18,520 --> 00:35:21,380
+للمادة الوراثية في الـ site الخاص بالـ sperm في
+
+493
+00:35:21,380 --> 00:35:24,540
+الـ cytoplasm الخاص بالـ oocyte عشان يبدأ عملية
+
+494
+00:35:24,540 --> 00:35:27,560
+الاندماج ما بين الـ maternal و الـ paternal
+
+495
+00:35:27,560 --> 00:35:33,240
+nucleic acid في بعضهم بقول ليه وبعض العلماء هنا
+
+496
+00:35:33,240 --> 00:35:36,500
+فيه نقطة اختلاف Also, mitochondria located in the
+
+497
+00:35:36,500 --> 00:35:39,900
+sperm neck enter the egg, they do not contribute
+
+498
+00:35:41,270 --> 00:35:44,750
+mitochondrial complement of the zygote يعني في ناس
+
+499
+00:35:44,750 --> 00:35:47,710
+بتحكي وعلماء بتقول أن الـ mitochondria الموجودة
+
+500
+00:35:47,710 --> 00:35:52,150
+في الـ neck أو الخاصة بالـ sperm تدخل مع المادة
+
+501
+00:35:52,150 --> 00:35:57,610
+الوراثية داخل الـ cytoplasm الخاص بالـ oocyte ولكن
+
+502
+00:35:57,610 --> 00:36:01,670
+لا تساهم في تكوين الـ zygote هل هذا صحيح؟ لأن في
+
+503
+00:36:01,670 --> 00:36:04,310
+ناس تانية بتقول لك لأ مافي عندي mitochondrial
+
+504
+00:36:04,310 --> 00:36:07,070
+paternal mitochondrial دي يعني مافي حاجة اسمها
+
+505
+00:36:07,070 --> 00:36:09,890
+paternal mitochondrial دي يعني ممكن ألجيها في
+
+506
+00:36:09,890 --> 00:36:13,990
+الجنين عشان كده صار في عنده اختلاف هل الـ DNA الخاص
+
+507
+00:36:13,990 --> 00:36:17,470
+في الـ mitochondria الموجود في الأجنة يتبع ال male
+
+508
+00:36:17,470 --> 00:36:21,190
+ولا يتبع ال female بمعنى آخر خاص بالأب paternal
+
+509
+00:36:21,190 --> 00:36:25,990
+ولا خاص بالأم maternal وهذا كان نقطة خلاف كبير جدا
+
+510
+00:36:25,990 --> 00:36:30,570
+ما بين العلماء على هذا الموضوع ولكن الموضوع أنه في
+
+511
+00:36:30,570 --> 00:36:34,710
+حاجة اسمها autophage system بتعمل engulfing لل
+
+512
+00:36:34,710 --> 00:36:37,950
+paternal mitochondria دي يعني إن دخلت ال cytoplasm
+
+513
+00:36:37,950 --> 00:36:41,120
+عشان كده جدا نادر ما بتشوف الـ Paternal
+
+514
+00:36:41,120 --> 00:36:45,100
+Mitochondria في البشر الـ sperm تشغّل الـ
+
+515
+00:36:45,100 --> 00:36:50,760
+Centrosome اللي محتاجه لتنزيف الجسد موجود في
+
+516
+00:36:50,760 --> 00:36:56,540
+المادة الوراثية للأب بشكل أساسي مهم جدا علشان يكمل
+
+517
+00:36:56,540 --> 00:37:01,340
+عملية الغسام الخاصة بالجنين ال paternal
+
+518
+00:37:01,340 --> 00:37:04,620
+mitochondria اللي حكينا فيها اندخلت خلال عملية ال
+
+519
+00:37:04,620 --> 00:37:09,640
+fertilization ووصلت لها ال fertilized oocyte أو
+
+520
+00:37:09,640 --> 00:37:12,760
+الـ cytoplasm الخاص بالـ fertilized oocyte هتلاقي
+
+521
+00:37:12,760 --> 00:37:17,420
+مباشرة فيه لها elimination يعني بتترد أو بيصيلها
+
+522
+00:37:17,420 --> 00:37:21,300
+breakdown أو degeneration بفعل إنزين يسميه
+
+523
+00:37:21,300 --> 00:37:27,660
+autophagocyte ولكن الطريقة والميكنزم حتى الآن في
+
+524
+00:37:27,660 --> 00:37:29,300
+عندي limitation
+
+525
+00:37:34,850 --> 00:37:41,310
+المتوفرة عن هذا السبب أو عن هذه القالية The 
+
+526
+00:37:41,310 --> 00:37:45,850
+inheritance of mitochondria اتفق العلماء أن معظم
+
+527
+00:37:45,850 --> 00:37:49,070
+الـ mitochondria في أجسادنا inherited from mother
+
+528
+00:37:49,070 --> 00:37:54,270
+so this type of mitochondria is maternal
+
+529
+00:37:54,270 --> 00:37:57,310
+inheritance يعني معظم الـ mitochondria في أجسادنا
+
+530
+00:37:57,310 --> 00:38:02,350
+أصلها ومصدرها الأم بسيط الفيرتاليزيات البيتيرنا
+
+531
+00:38:02,350 --> 00:38:02,990
+البيتيرنا البيتيرنا البيتيرنا البيتيرنا البيتيرنا
+
+532
+00:38:02,990 --> 00:38:12,570
+البيتيرنا البيتيرنا البيتيرنا البيتيرنا 
+
+533
+00:38:12,570 --> 00:38:14,250
+البيتيرنا البيتيرنا البيتيرنا البيتيرنا البيتيرنا
+
+534
+00:38:14,250 --> 00:38:16,110
+البيتيرنا البيتيرنا البيتيرنا البيتيرنا البيتيرنا
+
+535
+00:38:16,110 --> 00:38:19,210
+البيتيرنا
+
+536
+00:38:19,210 --> 00:38:23,750
+البيتيرنا
+
+537
+00:38:23,750 --> 00:38:26,610
+البيتيرنا البيتيرنا البيتيرنا البيتيرنا البيتيرنا
+
+538
+00:38:26,610 --> 00:38:27,990
+البيتيرنا البيتيرنا البيتيرنا البيتيرنا البيتيرنا
+
+539
+00:38:27,990 --> 00:38:28,050
+البيتيرنا البيتيرنا البيتيرنا البيتيرنا البيتيرنا
+
+540
+00:38:28,050 --> 00:38:31,190
+الRecently, several authors have found that
+
+541
+00:38:31,190 --> 00:38:33,270
+sperm mitochondrial DNA remains in the
+
+542
+00:38:33,270 --> 00:38:36,750
+preimplantation embryo دراسات لما اتطورت والأبحاث
+
+543
+00:38:36,750 --> 00:38:40,110
+وجدوا أنه في مرحلة ال preimplantation embryo، ال
+
+544
+00:38:40,110 --> 00:38:43,870
+embryo قبل عملية ال implantation وجدوا في عندي
+
+545
+00:38:43,870 --> 00:38:47,650
+بعض ال maternal mitochondrial DNA، طبعا هذا تفسيره
+
+546
+00:38:47,890 --> 00:38:51,710
+أنه قد يكون هناك خلل في الـ autophage system ففي
+
+547
+00:38:51,710 --> 00:38:55,450
+بعض الـ maternal mitochondria DNA scabbing وظلت
+
+548
+00:38:55,450 --> 00:38:58,630
+كما هي بدون ما يصير لها degeneration this finding ..
+
+549
+00:38:58,630 --> 00:39:02,570
+this finding suggests that spare mitochondrial DNA
+
+550
+00:39:02,570 --> 00:39:05,850
+is replicated compound and is not actively
+
+551
+00:39:05,850 --> 00:39:09,930
+eliminated during infragenesis ببساطة جدا ماصار لهاش
+
+552
+00:39:09,930 --> 00:39:13,250
+من elimination بفعل خلل في ال autophage system
+
+553
+00:39:13,250 --> 00:39:17,880
+وصار لها replication فتضعفت بكمية موجودة فوجدناها
+
+554
+00:39:17,880 --> 00:39:22,180
+فيما بعد and the other explanation is that the
+
+555
+00:39:22,180 --> 00:39:25,840
+mitophage mechanism of the oocyte is defect ببساطة
+
+556
+00:39:25,840 --> 00:39:30,260
+جدا يعني في عدة سببين السبب الأول أن الميتوفاج ..
+
+557
+00:39:30,260 --> 00:39:33,380
+الميكنزم اللي سميته autophage الخاص بالـ oocyte
+
+558
+00:39:33,380 --> 00:39:37,280
+defect أو السبب الثاني أنه صار لها replication
+
+559
+00:39:37,280 --> 00:39:40,800
+بكميات كبيرة جدا فأجد ما بدأت تشغل ال autophage مش
+
+560
+00:39:40,800 --> 00:39:46,170
+هتقضي عليها فبالتالي هذا صارت حالة .. طبعا ما 
+
+561
+00:39:46,170 --> 00:39:49,350
+اكتشفوهاش بكمية كبيرة جدا فقط حالات معدودة .. 7 ..
+
+562
+00:39:49,350 --> 00:39:52,730
+8 .. 9 حالات حتى الآن اكتشفوهم حتى بالـ whole 
+
+563
+00:39:52,730 --> 00:39:55,830
+genome sequencing أو الـ DNA Sequencing لما عملوا 
+
+564
+00:39:55,830 --> 00:39:59,370
+الـ DNA Sequencing للمادة الوراثية الموجودة في الـ
+
+565
+00:39:59,370 --> 00:40:01,530
+embryo لاقوا عندي تلاتة .. واحدة paternal ..
+
+566
+00:40:01,530 --> 00:40:04,430
+متقدرية واحدة maternal .. متقدرية واحدة paternal
+
+567
+00:40:04,430 --> 00:40:08,510
+.. متقدرية أو لاقوا تلاتة .. واحدة خاصة بالأب ..
+
+568
+00:40:08,510 --> 00:40:11,610
+واحدة خاصة بالأم .. والثالثة فيما بعد اكتشفوا أنها 
+
+569
+00:40:11,610 --> 00:40:14,700
+عبارة عن paternal .. متقدرية .. DNA sequence يعني
+
+570
+00:40:14,700 --> 00:40:18,700
+دليل أن الـ mitochondria الموجودة في الـ sperm قد
+
+571
+00:40:18,700 --> 00:40:24,480
+تتواجد و تتضاعف و تبقى في الـ imprint كده هنخلص هذا
+
+572
+00:40:24,480 --> 00:40:27,680
+الموضوع و هذه المحاضرة عند هذا الحد إن شاء الله
+
+573
+00:40:27,680 --> 00:40:32,000
+على أمل أن نلتقي في المحاضرة القادمة إن شاء الله
+
+574
+00:40:32,000 --> 00:40:33,780
+تم تم في رعاية الله 
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/e8zUWOaK1rw_postprocess.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/e8zUWOaK1rw_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ad64651fcb03cef923e4bdc03cdd047b4707afed
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/e8zUWOaK1rw_postprocess.srt
@@ -0,0 +1,2296 @@
+1
+00:00:01,480 --> 00:00:05,680
+باسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:05,680 --> 00:00:11,460
+المسلين سيدنا محمد وعلى آله وصحبه أجمعين بداية
+
+3
+00:00:11,460 --> 00:00:16,740
+نرجو من الله الكريم أن تكونوا جميعا بخير استكمالا
+
+4
+00:00:16,740 --> 00:00:20,580
+لمبدأنا فيه من سلسلة محاضرات التلقيح الصناعي
+
+5
+00:00:20,580 --> 00:00:26,520
+أسبابه وسبوله وطرقه المتنوعة تحدثنا في الأسبوع
+
+6
+00:00:26,520 --> 00:00:35,040
+الماضي عن رحلة لسبيرنبداية من الـ cervic حتى وصولا
+
+7
+00:00:35,040 --> 00:00:37,860
+إلى ال fallopian tube من أجل حدوث عملية ال
+
+8
+00:00:37,860 --> 00:00:43,180
+fertilization وما يواجله من مخاطر ومعويقات هذه
+
+9
+00:00:43,180 --> 00:00:49,140
+المخاطر والمعويقات تلعب دورا أساسيا في انقاس عدد
+
+10
+00:00:49,140 --> 00:00:53,380
+ال sperm الذي قد يصل إلى البويضة وهذا أمر طبيعي
+
+11
+00:00:53,380 --> 00:00:58,160
+وامر محمود ولكن بشرط أن لا يزيد عن الأمر الطبيعي
+
+12
+00:00:59,840 --> 00:01:04,340
+سنستكمل اليوم بعض النقاط المتعلقة بالـ Transport
+
+13
+00:01:04,340 --> 00:01:09,260
+of Gametes and Fertilization وهو الجزء الثالث من
+
+14
+00:01:09,260 --> 00:01:12,260
+هذا الـ chapter والذي يتحدث عن آلية ال
+
+15
+00:01:12,260 --> 00:01:15,680
+fertilization كيف تحدث ال fertilization و أين تحدث
+
+16
+00:01:15,680 --> 00:01:19,740
+عملية ال fertilization وما المانع من إخصاب البويضة
+
+17
+00:01:19,740 --> 00:01:23,480
+بتوسبيرم وإن تم إخصاب البويضة بتوسبيرم ماذا سوف
+
+18
+00:01:23,480 --> 00:01:28,200
+يحدث هذه أمور سوف نتطرق إليها خلال محاضرة الأسبوع
+
+19
+00:01:28,200 --> 00:01:32,910
+الحالي إن شاء اللهبداية و قبل أن نبدأ بعملية ال
+
+20
+00:01:32,910 --> 00:01:36,750
+fertilization توقفنا فيما سبق عند الكوربوس
+
+21
+00:01:36,750 --> 00:01:41,610
+اليوتيوم و كيف ينتج هذا الجسم الأصفر و تحدثنا أن
+
+22
+00:01:41,610 --> 00:01:44,370
+الجسم الأصفر في البداية هو عبارة عن ال graphian
+
+23
+00:01:44,370 --> 00:01:50,770
+follicle بعد عملية ال ovulation تتحول
+
+24
+00:01:50,770 --> 00:01:57,290
+إلى كوربوس اليوتيوم بسبب بخ الدم بكمية كبيرة جدا
+
+25
+00:01:57,290 --> 00:02:02,220
+إلى هذه المنطقةوهذه المنطقة تلعب دورة مهمة في
+
+26
+00:02:02,220 --> 00:02:07,440
+إبقاء الحمل إن حدث من خلال إفراز بعض الهرمونات
+
+27
+00:02:07,440 --> 00:02:11,040
+فبالتالي Rapture Follicle بين جثين Giraffen
+
+28
+00:02:11,040 --> 00:02:15,340
+Follicle undergoes a series of strict changes that
+
+29
+00:02:15,340 --> 00:02:18,620
+are essentially for progression and of even
+
+30
+00:02:18,620 --> 00:02:23,500
+leading and supporting pregnancyيعني هذه التحولات
+
+31
+00:02:23,500 --> 00:02:26,400
+والتغيرات اللي بتصير على الجرفيا الفوليكي بعد
+
+32
+00:02:26,400 --> 00:02:30,460
+عملية ال ovulation تعتبر عاملًا حيويًا وعاملًا
+
+33
+00:02:30,460 --> 00:02:35,720
+أساسيًا في بقاء الحمل إن حدث و تدعيمه فبالتالي
+
+34
+00:02:35,720 --> 00:02:40,360
+وجودها ليس بالأمر الافتراضي الذي يحدث بشكل عشوائي
+
+35
+00:02:41,510 --> 00:02:44,630
+فماذا يحدث بعد عملية الـ ovulation؟ مباشرة بعد
+
+36
+00:02:44,630 --> 00:02:47,730
+عملية الإبادة الـ basement membrane الخاص بالـ
+
+37
+00:02:47,730 --> 00:02:52,190
+griffion follicle that's separated the granulosa
+
+38
+00:02:52,190 --> 00:02:56,330
+cell from the theca breakdown those allowing
+
+39
+00:02:56,330 --> 00:02:59,690
+thecal blood vessels to grow into the cavity of
+
+40
+00:02:59,690 --> 00:03:04,310
+the ruptured follicle يعني عملية الـ separation
+
+41
+00:03:04,310 --> 00:03:08,230
+اللي بتحدث ما بين الـ theca cell و ال granulosa
+
+42
+00:03:08,230 --> 00:03:12,180
+cell اللي موجودة في ال basement membraneللـ
+
+43
+00:03:12,180 --> 00:03:16,140
+Graafian Follicle تسمح بضخ كمية كبيرة جدا من الدم
+
+44
+00:03:16,140 --> 00:03:22,780
+في هذه المنطقة مما يسمح بتكوين الكوربوس اليوتر
+
+45
+00:03:22,780 --> 00:03:25,480
+فيما بعد و هذا بيقولك allowing thecal blood
+
+46
+00:03:25,480 --> 00:03:28,140
+vessels ال blood vessels الموجودة في الثيكل أنها
+
+47
+00:03:28,140 --> 00:03:33,030
+تنمو و تضخ كمية كبيرة جدا من الدمالمحمّد بالمواد
+
+48
+00:03:33,030 --> 00:03:36,650
+الغذائية في الـ cavity بعد عملية الـ rupture الـ
+
+49
+00:03:36,650 --> 00:03:39,710
+granulosa cell تعمل stimulation أو بيصيرلها
+
+50
+00:03:39,710 --> 00:03:43,030
+stimulation أو خلّيني أسميها بمعنى آخر بيصيرلها
+
+51
+00:03:43,030 --> 00:03:48,270
+variation و changing بفعل تلقائي مما يؤدي إلى
+
+52
+00:03:48,270 --> 00:03:52,170
+سلسلة من التغيرات هذه التغيرات تحدث في الشكل و في
+
+53
+00:03:52,170 --> 00:03:55,750
+الوظيفة نطلق على هذه التغيرات عملية بيسميها
+
+54
+00:03:55,750 --> 00:04:00,550
+لوتونيزيشن لذا اللوتونيزيشن هي a series or group
+
+55
+00:04:00,550 --> 00:04:06,100
+ofModification happened on granulosa cell لماذا
+
+56
+00:04:06,100 --> 00:04:11,040
+تحدث عن granulosa cell؟ لكي تخدم الوظيفة التي كانت
+
+57
+00:04:11,040 --> 00:04:15,540
+كوّنة لأجلها فيما بعد إذا اتحولت المكان إلى كورباس
+
+58
+00:04:15,540 --> 00:04:18,100
+اليوتيام أو الفولك الهادي اتحول إلى كورباس
+
+59
+00:04:18,100 --> 00:04:23,960
+اليوتيام وبقيت لتخدم الحمل خلال ما يقارب من 30 إلى
+
+60
+00:04:23,960 --> 00:04:30,060
+40 ساعة بعد ال ال H-waveبعد الـ high peak للـ LH
+
+61
+00:04:30,060 --> 00:04:33,740
+احسب تلاتين لاربعين ساعة this cell اللي سميتها
+
+62
+00:04:33,740 --> 00:04:38,620
+granulosa cell تسمى فيما بعد او تتحول فيما بعد إلى
+
+63
+00:04:38,620 --> 00:04:44,200
+خلايا اخرى تسمى granulosa utian cell اذا ال
+
+64
+00:04:44,200 --> 00:04:46,720
+granulosa cell بعد ما يصير عليها ال modification
+
+65
+00:04:46,720 --> 00:04:51,240
+اللي احنا حكينا عنه وسميناه lutealization بعد
+
+66
+00:04:51,240 --> 00:04:56,560
+اربعين ساعة من ال lutealizationأصبحت تسمى
+
+67
+00:04:56,560 --> 00:05:01,460
+Granulosa Lutein Cell وإلها وظيفة معينة Beginning
+
+68
+00:05:01,460 --> 00:05:06,060
+secreting increasing amount of progesterone along
+
+69
+00:05:06,060 --> 00:05:09,380
+with some estrogen إذن هذه الجرانيلوزا سيل اللي
+
+70
+00:05:09,380 --> 00:05:13,740
+اتحولت إلى Granulosa Lutein Cell أصبحت تلعب دورة
+
+71
+00:05:13,740 --> 00:05:19,400
+مهمة في إفراز كمية كبيرة وكافية من البروجسترون
+
+72
+00:05:19,400 --> 00:05:23,510
+بالإضافة إلى كمية من الاستروجينوالبروجيسترون عرفنا
+
+73
+00:05:23,510 --> 00:05:28,050
+في مصبق أنه همور مهم جدا يساعد على بقاء الحمل
+
+74
+00:05:28,050 --> 00:05:31,750
+وعملية ال implantation مهم جدا عملية ال
+
+75
+00:05:31,750 --> 00:05:36,250
+implantation لأن بدونها بصير عندي a portion in the
+
+76
+00:05:36,250 --> 00:05:39,810
+first trimester ولما نقول first trimester يعني أول
+
+77
+00:05:39,810 --> 00:05:45,010
+ثلاثة شهور من عملية الحمل ال granulosa اليوتيان
+
+78
+00:05:45,010 --> 00:05:49,530
+cell are terminally differentiated يعني بتصير
+
+79
+00:05:49,530 --> 00:05:52,320
+لعملية differentiatedتنتهي عملية الـ
+
+80
+00:05:52,320 --> 00:05:56,760
+differentiated وتبقى كما هي في مبتعد بمجرد
+
+81
+00:05:56,760 --> 00:06:01,880
+انقسامها يتوقف أو توقف عملية الانقسام تتوقف خلاص
+
+82
+00:06:01,880 --> 00:06:05,260
+بمجرد تحويل الـ granulosa cell إلى granulosa الـ
+
+83
+00:06:05,260 --> 00:06:08,440
+lutein cell مافي انقسام بعد كده مافي
+
+84
+00:06:08,440 --> 00:06:12,200
+differentiation توقفت جميع عمليات الانقسام وعمليات
+
+85
+00:06:12,200 --> 00:06:16,400
+التمييز المتعلقة بالـ granulosa cell بمجرد تحولها
+
+86
+00:06:16,400 --> 00:06:22,630
+إلى granulosa lutein cell بفعل lotalizationbut
+
+87
+00:06:22,630 --> 00:06:25,890
+they continued to secreted progesterone for 10
+
+88
+00:06:25,890 --> 00:06:29,350
+days طبعا مهمة جدا بيقولك صحيح ان اتحولت من
+
+89
+00:06:29,350 --> 00:06:33,510
+granulosa cell ل granulosa lutein cell واتوقفت من
+
+90
+00:06:33,510 --> 00:06:37,970
+انقسام واتوقفت من التمايز يعني هتبقى كما هي ولكنها
+
+91
+00:06:37,970 --> 00:06:41,790
+تبقى تلعب دورة مهمة في إفراز ال progesterone لمدة
+
+92
+00:06:41,790 --> 00:06:46,650
+عشر أيام او عشر أيام طب ليه؟ ببساطة جدا لإن خلال
+
+93
+00:06:46,650 --> 00:06:50,450
+فترة العشر أيام يجب أن تتكوّل بلسنتر
+
+94
+00:06:53,640 --> 00:06:58,320
+عفراز البروجيسترون منها وبالتالي يتوقف عفراز
+
+95
+00:06:58,320 --> 00:07:02,960
+البروجيسترون من الجرانيولوجيا اليوتيان سيت قدت
+
+96
+00:07:02,960 --> 00:07:06,400
+وظيفتها بعد عشر أيام خدوا بالك ليش بعد عشر أيام؟
+
+97
+00:07:06,400 --> 00:07:10,440
+لأن في فترة هذه يا إما بيصير pregnancy موجود وصار
+
+98
+00:07:10,440 --> 00:07:13,120
+له implantation يا إما مافيه عنده pregnancy
+
+99
+00:07:13,120 --> 00:07:18,740
+فبالتالي بيصير عنده menstrual cycle جديد The
+
+100
+00:07:18,740 --> 00:07:21,960
+secretion of human coronaginatotropin اللي بتسمي
+
+101
+00:07:21,960 --> 00:07:26,060
+HCGيلعب دورة مهمة في عملية الـ Maintenance of
+
+102
+00:07:26,060 --> 00:07:29,920
+Pregnancy until approximately the seventh week of
+
+103
+00:07:29,920 --> 00:07:35,100
+the pregnancy أو الـ gestation يعني بمعنى أخر أن
+
+104
+00:07:35,100 --> 00:07:39,560
+الهرمون اللي سميته HCG وهو اختصار له Human Chronic
+
+105
+00:07:39,560 --> 00:07:43,760
+Gonadotropin هذا مش هرمون عبث يفرز، لأ هرمون مهم
+
+106
+00:07:43,760 --> 00:07:50,060
+جدا يفرز بشكل مستمر ويلعب دورة أساسية ومهمة بجانب
+
+107
+00:07:50,060 --> 00:07:55,450
+البروجسترونفي المحافظة على الحمل وبقاءه لمدة ما
+
+108
+00:07:55,450 --> 00:08:00,770
+يقارب سبع أسابيع لمدة أول سبع أسابيع من الحمل ما
+
+109
+00:08:00,770 --> 00:08:04,010
+بين الأسبوع السابع للأسبوع العاشر من عملية الحمل
+
+110
+00:08:04,010 --> 00:08:08,230
+ال Corpus Luteum is replaced by the placenta in
+
+111
+00:08:08,230 --> 00:08:14,530
+term of progesterone production يعني بعد السبع
+
+112
+00:08:14,530 --> 00:08:19,290
+أسابيع وصولا للأسبوع العاشر البروجسترون يفقد
+
+113
+00:08:24,490 --> 00:08:29,330
+يعني الكوربوس اليوتياب تدريجيا يفقد قدرته على
+
+114
+00:08:29,330 --> 00:08:34,350
+إخراج وإفراز البروجسترون فمن سيحل محله؟ سيحل محله
+
+115
+00:08:34,350 --> 00:08:38,750
+الـ placental اللي بدأ تتكوّن هذه الفترة عملية
+
+116
+00:08:38,750 --> 00:08:41,110
+التحول وهذا الـ event اللي بتصير وهذا الطول اللي
+
+117
+00:08:41,110 --> 00:08:46,200
+بيصير هذه الفترة من عملية اليوتيابUteal Placenta
+
+118
+00:08:46,200 --> 00:08:50,420
+Shift ماهي المقصود فيها؟ بداية في أربع نقاط بسيطة
+
+119
+00:08:50,420 --> 00:08:54,300
+جدا جرانيلوزا سيل اتحولت إلى الجرانيلوزا اليوتيان
+
+120
+00:08:54,300 --> 00:09:00,460
+سيل قادر على إفراز البروجسترون وكمية من الاستروجين
+
+121
+00:09:00,460 --> 00:09:05,320
+البروجسترون مهم جدا في إبقاء الحمل و المساعدة على
+
+122
+00:09:05,320 --> 00:09:11,360
+الimplantationيبقى هذه العملية لمدة 7 أسابيع أول 7
+
+123
+00:09:11,360 --> 00:09:14,560
+أسابيع من عملية الحميدة ما بين السبوع السابع
+
+124
+00:09:14,560 --> 00:09:18,080
+والعشر تبدأ البلانسينتا في التكون لكي تأخذ مكان
+
+125
+00:09:18,080 --> 00:09:22,860
+الكوربوس اليوتيوم في إفراز البروجسترون بمجرد توقف
+
+126
+00:09:22,860 --> 00:09:27,340
+إفراز البروجسترون من الكوربوس اليوتيوم وإفرازه من
+
+127
+00:09:27,340 --> 00:09:31,760
+البلانسينتا هذه العملية بنسميها الـUtil Placental
+
+128
+00:09:31,760 --> 00:09:37,850
+Shift بمعنى آخر برجسترون as hormoneبدل ما يُفرَز
+
+129
+00:09:37,850 --> 00:09:40,850
+من الـ Luteal جرانيولوجيا الـ Luteal Cell أصبح
+
+130
+00:09:40,850 --> 00:09:45,230
+يُفرَز من الـ Placenta شيء كده يسموها Luteal الأصل
+
+131
+00:09:45,230 --> 00:09:50,690
+Placental الجديدة Shift من إلها In conception
+
+132
+00:09:50,690 --> 00:09:55,690
+cycle the life of the corpus luteum is extended
+
+133
+00:09:55,690 --> 00:09:58,570
+until the luteal placenta shift again يعني في
+
+134
+00:09:58,570 --> 00:10:02,230
+الوضع الطبيعي بقولك ال corpus luteum يبقى متوفر
+
+135
+00:10:02,230 --> 00:10:08,390
+يبقى فعال يبقى يعمل على إفراج البروجسترونحتى تكوّل
+
+136
+00:10:08,390 --> 00:10:11,790
+الـ placenta بمجرد تكوّل الـ placenta يتوقف عن
+
+137
+00:10:11,790 --> 00:10:17,370
+عملية الإفراز يعني بمعنى آخر وبشكل منطقي المفروض
+
+138
+00:10:17,370 --> 00:10:21,630
+يتوقف بشكل كامل عند الأسبوع العاشر ويبدأ بعد كده
+
+139
+00:10:21,630 --> 00:10:24,970
+في عملية ال degradation أو ال atrophy فده يعني
+
+140
+00:10:24,970 --> 00:10:29,410
+الكوربس اليوتيوم in the absence of fertilization
+
+141
+00:10:29,410 --> 00:10:33,410
+ماصارش فيه fertilization and hormone stimulus
+
+142
+00:10:33,410 --> 00:10:37,340
+provided by the early embryoالكوربس اليوتيام يبدأ
+
+143
+00:10:37,340 --> 00:10:41,440
+بالتخصيب للبوايضة والتخصيب للبوايضة والتخصيب
+
+144
+00:10:41,440 --> 00:10:46,260
+للبوايضة والتخصيب للبوايضة والتخصيب للبوايضة
+
+145
+00:10:46,260 --> 00:10:46,520
+والتخصيب للبوايضة والتخصيب للبوايضة والتخصيب
+
+146
+00:10:46,520 --> 00:10:48,260
+للبوايضة والتخصيب للبوايضة والتخصيب للبوايضة
+
+147
+00:10:48,260 --> 00:10:49,540
+والتخصيب للبوايضة والتخصيب للبوايضة والتخصيب
+
+148
+00:10:49,540 --> 00:10:54,900
+للبوايضة والتخصيب للبوايضة والتخصيب للبوايضة
+
+149
+00:10:54,900 --> 00:11:02,840
+والتخصيب للبوايضة والتخصيب للبوايضة والتخصيب
+
+150
+00:11:02,840 --> 00:11:12,290
+للبالنسبة للبروجيسترون ستكون تنقس
+
+151
+00:11:12,290 --> 00:11:16,790
+بشكل تدريجي او
+
+152
+00:11:16,790 --> 00:11:19,370
+تنقس او تدريجي او تدريجي او تدريجي او تدريجي او
+
+153
+00:11:19,370 --> 00:11:20,370
+تدريجي او تدريجي او تدريجي او تدريجي او تدريجي او
+
+154
+00:11:20,370 --> 00:11:21,710
+تدريجي او تدريجي او تدريجي او تدريجي او تدريجي او
+
+155
+00:11:21,710 --> 00:11:23,790
+تدريجي او تدريجي او تدريجي او تدريجي او تدريجي او
+
+156
+00:11:23,790 --> 00:11:30,550
+تدريجي او تدريجي او تدريجي او تلأنه مافي بلسنت
+
+157
+00:11:30,550 --> 00:11:35,390
+أتكونت فبالتالي بعد 8 أسابيع أو 10 أسابيع مالوش
+
+158
+00:11:35,390 --> 00:11:38,970
+function فبصير له لوتوليزي اللي أنا حكيتها قبل
+
+159
+00:11:38,970 --> 00:11:43,030
+بشوية أو الـdegeneration طيب، this is necessary to
+
+160
+00:11:43,030 --> 00:11:45,510
+allow the development of a new follicle providing
+
+161
+00:11:45,510 --> 00:11:49,810
+a new chance for fertilization بمجرد أنه يبدأ
+
+162
+00:11:49,810 --> 00:11:53,590
+الكوربسليوتن في ال degradation أو ال breakdown هذا
+
+163
+00:11:53,590 --> 00:11:57,720
+بيعطي إشارة مباشرة إلى الhybrophilomasبعد ذلك إلى
+
+164
+00:11:57,720 --> 00:11:59,960
+الـ anterior loop of the pituitary gland عشان تبدأ
+
+165
+00:11:59,960 --> 00:12:04,660
+دورة جديدة من إفراز ال FSH والLH عشان يعطيني دورة
+
+166
+00:12:04,660 --> 00:12:09,140
+شهرية جديدة وعملية إبادة جديدة جديدة مما يسمح
+
+167
+00:12:09,140 --> 00:12:15,280
+بحدود الحمل مستقبلاً and it's okay by the 22 to 24
+
+168
+00:12:15,280 --> 00:12:19,140
+of menstrual cycle يعني بمعنى أخر أن هذه العملية و
+
+169
+00:12:19,140 --> 00:12:25,100
+هذه ال atrophy تبدأ بتصيرفي اليوم 22 لليوم 24 من
+
+170
+00:12:25,100 --> 00:12:29,520
+الدورة عشان تبدأ دورة جديدة تماشي ماتبيحدث إذا
+
+171
+00:12:29,520 --> 00:12:32,760
+ماصارش fertilization يعني there is no pregnancy
+
+172
+00:12:32,760 --> 00:12:36,300
+خدوا
+
+173
+00:12:36,300 --> 00:12:40,360
+بالكوا من الكلام مافي مشكلة بعد سبع أسابيع بيصيروا
+
+174
+00:12:40,360 --> 00:12:44,320
+أثروا فيه بعد سبع أسابيع هو فبتوقف خليني أسميه إذا
+
+175
+00:12:44,320 --> 00:12:47,680
+جاز التعبير لإنه لبدأ سنة أخدت الكمل أكبر
+
+176
+00:12:50,310 --> 00:12:54,050
+خلاص فصار له reduction في ال functional limit هذا
+
+177
+00:12:54,050 --> 00:12:58,540
+يعني الكوربوس اليتيحولكن لو ماصارش حمل مافيش داعي
+
+178
+00:12:58,540 --> 00:13:03,840
+إنه يستمر في إنتاج البروجسترون عشان كده بتوقف و
+
+179
+00:13:03,840 --> 00:13:06,900
+ببدأ يدخل فيه الـdegeneration في اليوم ال 22 من
+
+180
+00:13:06,900 --> 00:13:10,400
+الدورة إذا المعلومة الأولى مافيها تعارض في
+
+181
+00:13:10,400 --> 00:13:13,560
+المعلومة التانية المعلومة الأولى تتعلق إذا صار
+
+182
+00:13:13,560 --> 00:13:16,720
+pregnancy المعلومة التانية إذا ماصارش pregnancy
+
+183
+00:13:16,720 --> 00:13:21,100
+تمام؟ تمام ال second phase the functional
+
+184
+00:13:33,860 --> 00:13:37,460
+مهم جدًا بعد ما يصيره الـ Degeneration و يصير
+
+185
+00:13:37,460 --> 00:13:39,420
+Reduction عفويا، بعد ما يصير Reduction في
+
+186
+00:13:39,420 --> 00:13:42,640
+البروجسترون و يبدأ يصير له Lutealization و
+
+187
+00:13:42,640 --> 00:13:46,420
+Degeneration لازم يصير Removing للقربس اليوتيام
+
+188
+00:13:46,420 --> 00:13:49,920
+بشكل كامل علشان ما يصيرش Accumulation لأنه كده
+
+189
+00:13:49,920 --> 00:13:54,280
+بالك كل دورةبيصير عندك Corpus Luteum Formation لأن
+
+190
+00:13:54,280 --> 00:13:58,340
+أصد الـ Corpus Luteum هو عبارة عن Graphene
+
+191
+00:13:58,340 --> 00:14:01,420
+Follicle اللي بتطلع منها البويضة إذا كل عملية
+
+192
+00:14:01,420 --> 00:14:05,000
+إبادة وخروج بويضة في عندك Graphene Follicle تتحول
+
+193
+00:14:05,000 --> 00:14:09,160
+إلى Corpus Luteum تصور على مدار السنة في عندك مثلا
+
+194
+00:14:09,160 --> 00:14:15,150
+على أقل تقليد 12عملية لبعضة، يعني إتناشر فوريكل،
+
+195
+00:14:15,150 --> 00:14:17,650
+يعني إتناشر كوربا سليوتين إذا صار accumulation
+
+196
+00:14:17,650 --> 00:14:23,230
+لهذه الأنسجة مع بعض لبعض تؤدي إلى حدوث مشكلة في ال
+
+197
+00:14:23,230 --> 00:14:27,490
+over it إحنا ك human في غين عنها، إحنا ك human في
+
+198
+00:14:27,490 --> 00:14:30,630
+غين عنها فبالتالي لازم يصير ال degeneration و
+
+199
+00:14:30,630 --> 00:14:36,970
+removing لكوربا سليوتين بشكل كاملremoving الكوربا
+
+200
+00:14:36,970 --> 00:14:42,110
+سليوتيام بشكل ثوري ولكن بياخد فترة زمانية طويلة
+
+201
+00:14:42,110 --> 00:14:45,450
+إلى حد ما مش طويلة يعني سنين لأ طويلة إلى حد ما
+
+202
+00:14:45,450 --> 00:14:48,710
+مقصود بالcycle مش بعد كل cycle بروح وبنتي بده
+
+203
+00:14:48,710 --> 00:14:51,730
+اتنين اتلات اربع cycle عشان ينتهي الاول كوربا
+
+204
+00:14:51,730 --> 00:14:55,210
+سليوتيام عشان كده بحكيلي انه ال structure
+
+205
+00:14:55,210 --> 00:14:58,230
+lutealized and its beginning after the degrees of
+
+206
+00:14:58,230 --> 00:15:01,810
+progesterone as we said secretion also complete
+
+207
+00:15:01,810 --> 00:15:04,750
+deletion of the كوربا سليوتيامshould be take
+
+208
+00:15:04,750 --> 00:15:08,370
+several cycle يعني ممكن بعد 20 cycle كوربس
+
+209
+00:15:08,370 --> 00:15:12,250
+اليوتيام يختفي الأول اللي اتكون هذه الفكرة المقصود
+
+210
+00:15:12,250 --> 00:15:17,250
+فيها يعني بمعنى أخر مش انتهاء الدورة ومافي عملية
+
+211
+00:15:17,250 --> 00:15:20,770
+pregnancy ينتهي الكوربس اليوتيام بشكل فوري لأ
+
+212
+00:15:20,770 --> 00:15:24,090
+بياخد several cycle ممكن تكون خمسة، ستة، سبعة،
+
+213
+00:15:24,090 --> 00:15:29,590
+عشر، بيننا على طبيعة السيدةDuring the regeneration
+
+214
+00:15:29,590 --> 00:15:32,830
+of the corpus luteum, the granulosa luteum cell
+
+215
+00:15:32,830 --> 00:15:37,810
+degenerate and are replaced with collagenous scar
+
+216
+00:15:37,810 --> 00:15:40,770
+tissue خلال عملية الـdegeneration و الـlysis،
+
+217
+00:15:40,770 --> 00:15:44,150
+الجرانولوزا السل تتحول وتستبدل وتكسى
+
+218
+00:15:44,150 --> 00:15:48,110
+بالـcollagenous tissue لونها أبيض، عشان كده
+
+219
+00:15:48,110 --> 00:15:50,850
+الـcorpus luteum بتتحول من corpus luteum with
+
+220
+00:15:50,850 --> 00:15:55,050
+yellow color إلى corpus albicum with white color،
+
+221
+00:15:55,050 --> 00:15:59,300
+لأنه عبارة عن أليافكل جيل والكل جيل دائما أبيض
+
+222
+00:15:59,300 --> 00:16:03,720
+اللون لذلك كوربس اليوتيام في حالة شيخوخته خلّيني
+
+223
+00:16:03,720 --> 00:16:08,540
+أسميه أو توجهه إلى الـdegeneration phase بتحول من
+
+224
+00:16:08,540 --> 00:16:11,780
+اللون الأصفر إلى اللون الأبيض بسميه كوربس اليوتيام
+
+225
+00:16:11,780 --> 00:16:21,780
+2 كوربس البكند ده السؤال المهم جدافهمنا كيف تحدث
+
+226
+00:16:21,780 --> 00:16:25,580
+الـ ovulation فهمنا كيف تتحول الجريفيا الفوليكية
+
+227
+00:16:25,580 --> 00:16:29,120
+إلى كوربس اليوتيام فهمنا متى يختفي الكوربس
+
+228
+00:16:29,120 --> 00:16:33,760
+اليوتيام سواء كان في ال case pregnant أو non
+
+229
+00:16:33,760 --> 00:16:37,320
+-pregnant شو بيحصل في ال fertilization؟ وشو هي ال
+
+230
+00:16:37,320 --> 00:16:40,500
+fertilization؟ و أين بتحصل ال fertilization؟ ال
+
+231
+00:16:40,500 --> 00:16:44,120
+fertilization ببساطة جدا هي عملية تحدث عند القيقاء
+
+232
+00:16:44,120 --> 00:16:50,830
+الجميطات process should be occur when جميطface to
+
+233
+00:16:50,830 --> 00:16:54,370
+face يعني الجميع بتبقى face to face علشان يصير في
+
+234
+00:16:54,370 --> 00:16:57,990
+coupling ما بينهم أو joint ما بينهم إيش يعني
+
+235
+00:16:57,990 --> 00:17:00,510
+coupling و إيش يعني joint؟ مش coupling بالشكل
+
+236
+00:17:00,510 --> 00:17:04,030
+المتعارف أو الشكل المتوقع ولكن هي عبارة عن
+
+237
+00:17:04,030 --> 00:17:07,310
+penetration لل spear ال oocyte يحدث لها
+
+238
+00:17:07,310 --> 00:17:11,970
+penetration بواصل spear only one single spear أي
+
+239
+00:17:11,970 --> 00:17:15,130
+بويضة تخصّف ب two spear إن حدث بيصيرها
+
+240
+00:17:15,130 --> 00:17:18,330
+degeneration مباشرة إن حدث بيصيرها degeneration
+
+241
+00:17:18,330 --> 00:17:22,620
+مباشرةإتفقنا؟ إتفقنا When spermatozoa started to
+
+242
+00:17:22,620 --> 00:17:26,300
+penetrate the coronary dieta that surrounding the
+
+243
+00:17:26,300 --> 00:17:32,000
+egg and end with the invasion of the maternal and
+
+244
+00:17:32,000 --> 00:17:35,580
+paternal chromosomes after spermatozoa has entered
+
+245
+00:17:35,580 --> 00:17:38,860
+the egg يعني هي عبارة عن عملية تبدأ باقتراط ال
+
+246
+00:17:38,860 --> 00:17:42,420
+sperm ال male gametes من ال female gametes ال
+
+247
+00:17:42,420 --> 00:17:45,930
+Oocyteيبدأ الـ sperm باختراق الـ corona radiata
+
+248
+00:17:45,930 --> 00:17:51,450
+السلسة المحيطة فيها ثم الـ zona pellucida ثم تندمج
+
+249
+00:17:51,450 --> 00:17:54,210
+المادة الوراثية الخاصة بالـ maternal بالمادة
+
+250
+00:17:54,210 --> 00:17:58,110
+الوراثية الخاصة بالـ maternal اندماجا كاملا من
+
+251
+00:17:58,110 --> 00:18:02,990
+حصول نواة واحدة هنا بسميها fertilized oocyte
+
+252
+00:18:02,990 --> 00:18:08,550
+fertilized oocyte يعني بويضة مخصمة ال corona
+
+253
+00:18:08,550 --> 00:18:12,790
+radiata هي عبارة عن خلايا تحيط بالـ oocytewith a
+
+254
+00:18:12,790 --> 00:18:16,410
+high cellular layer with an intracellular matrix
+
+255
+00:18:16,410 --> 00:18:19,370
+consist of يعني هي عبارة عن خلايا محيطة بالـ
+
+256
+00:18:19,370 --> 00:18:22,170
+Oocyte من الخارج ولكن ال matrix في الداخل التابع
+
+257
+00:18:22,170 --> 00:18:29,450
+الخاص فيها يحتوي على مواد أخرىالبروتينز بشكل أساسي
+
+258
+00:18:29,450 --> 00:18:33,990
+ال high concentration of carbohydrate and
+
+259
+00:18:33,990 --> 00:18:37,610
+hyaluronic acid خدوا بالك المواد هذه مهمة جدا لازم
+
+260
+00:18:37,610 --> 00:18:41,450
+تكون فيها لأنها بتغذ البويضة بشكل أساسي في المراحل
+
+261
+00:18:41,450 --> 00:18:45,850
+الأولى من عملية ال maturation it is why believed
+
+262
+00:18:45,850 --> 00:18:51,910
+that hyaluronidase present
+
+263
+00:18:51,910 --> 00:18:56,050
+or released from the head of a sperm play a very
+
+264
+00:18:56,050 --> 00:19:00,390
+important roleوبين تريدت كورونا ردياتا طالما أن
+
+265
+00:19:00,390 --> 00:19:03,490
+كورونا ردياتا هذه الخلية فيها مراكب اسمه الهيارونك
+
+266
+00:19:03,490 --> 00:19:08,470
+أسد طبيعي ومنطقي يجب أن يكون في ال sperm head
+
+267
+00:19:08,470 --> 00:19:12,390
+إنزين يكسر هذه المكونة لماذا هذه المكونة موجودة؟
+
+268
+00:19:12,390 --> 00:19:15,870
+أو لماذا هذه المادة موجودة؟ الهيارونك أسد الموجود
+
+269
+00:19:15,870 --> 00:19:19,210
+في كورونا ردياتا بحافظ على تماسك الخلايا حول
+
+270
+00:19:19,210 --> 00:19:23,210
+البويضة عشان ال sperm يخترق هذا التماسك البنيان
+
+271
+00:19:23,210 --> 00:19:27,610
+المرسوسحول البوايدة لازم يعمل تكسير في هذا البنيان
+
+272
+00:19:27,610 --> 00:19:31,830
+أو تكسير في المادة الموجودة فبيفرز الـ heto-sperm
+
+273
+00:19:31,830 --> 00:19:37,050
+بيحتوي على vesicles تفرز انزيم بيشتغل ضد الـ
+
+274
+00:19:37,050 --> 00:19:41,050
+hyaluronic acid اسمه hyaluronidase enzyme بيعمل
+
+275
+00:19:41,050 --> 00:19:46,070
+breakdown for this complex فبيساعد الـ sperm على
+
+276
+00:19:46,070 --> 00:19:51,800
+اختراق البوايدةمن خلال اختراق الكورونا رادياتا but
+
+277
+00:19:51,800 --> 00:19:55,000
+the active swimming movement of the sperm are also
+
+278
+00:19:55,000 --> 00:19:58,860
+important هل يعني ان ال sperm يستطيع اختراق
+
+279
+00:19:58,860 --> 00:20:04,360
+البويضة من خلال افراز المادة اللي سمتها هيرونيد من
+
+280
+00:20:04,360 --> 00:20:09,760
+خلال افراز المادة التي تعمل على الهيرونك أسد؟ لأ
+
+281
+00:20:09,760 --> 00:20:13,400
+صح هي بتلعب دور أساسي ولكن لازم plus ال movement
+
+282
+00:20:13,400 --> 00:20:17,400
+وحنشوفها كمان شوية تحت انوار ال activation ال
+
+283
+00:20:17,400 --> 00:20:21,020
+movement حنشوفهابشرحها و نسمعها و نشوفها في فيديو
+
+284
+00:20:21,020 --> 00:20:24,340
+ان شاء الله اذا عملية ال penetration تعتمد على
+
+285
+00:20:24,340 --> 00:20:28,180
+نقطتين أساسيتين افراز انزيم يعمل على الهيارونك أسد
+
+286
+00:20:28,180 --> 00:20:34,640
+الهيارونك أسد بيشتغل عليه و ال movement اللي تحدث
+
+287
+00:20:34,640 --> 00:20:37,480
+في ال sperm من خلال ال swimming من خلال ال
+
+288
+00:20:37,480 --> 00:20:45,420
+swimming اخترق ال sperm ال corona radiata بعد كده
+
+289
+00:20:45,420 --> 00:20:50,890
+لازم يواجهالحائط الآخر أو المانع الآخر جاء من و
+
+290
+00:20:50,890 --> 00:20:54,710
+يصل للمادة الوراثية اللي خاصة بالبويضة وهذا المانع
+
+291
+00:20:54,710 --> 00:21:00,490
+يسمى ZD وهو عبارة عن زونافليوسيدا، so the sperm
+
+292
+00:21:00,490 --> 00:21:04,090
+should be penetrated the zoonapelucida after
+
+293
+00:21:04,090 --> 00:21:07,660
+attachment with the receptorThe Outer Surface of
+
+294
+00:21:07,660 --> 00:21:12,100
+Zoonopathy وفي رسبتور على الـ Oocyte أكيد في
+
+295
+00:21:12,100 --> 00:21:14,860
+رسبتور و لا كيف بتصير فيه أنه عندي نوع من أنواع
+
+296
+00:21:14,860 --> 00:21:19,080
+التخصصية أو الخصوصية ال specificity كيف بتصير و
+
+297
+00:21:19,080 --> 00:21:25,520
+إلا ممكن أحطن بوايض ال human مثلا بوايض الطائر نطف
+
+298
+00:21:25,520 --> 00:21:29,020
+تعتبط خاصة بطائر معين أو بحيوان معين و هذا شيء غير
+
+299
+00:21:29,020 --> 00:21:33,960
+منطقي فبالتالي في رسبتور مهم جدا علشان يصير في
+
+300
+00:21:33,960 --> 00:21:37,730
+عنديattachment ثم penetration ثم fertilization
+
+301
+00:21:37,730 --> 00:21:44,430
+زوناف اليوسيدا ثقنسها يقدر بحوالي 13 ميكромتر تبعد
+
+302
+00:21:44,430 --> 00:21:49,650
+خاصة بـ human female oocyte تتكوّر من جليكو بروتين
+
+303
+00:21:49,650 --> 00:21:55,670
+بشكل أساسي تقسم إلى زوناف اليوسيدا 1,2,3,4 جمعها
+
+304
+00:21:55,670 --> 00:21:59,930
+مع بعضها لتصميم جزء أساسي من الـ polymerized into
+
+305
+00:21:59,930 --> 00:22:03,720
+long filamentيعني هذه ترتبط مع بعضها البعض عشان
+
+306
+00:22:03,720 --> 00:22:07,900
+تديني الـ Zoonopelucida الكاملة المتعرف عليها طبعا
+
+307
+00:22:07,900 --> 00:22:11,820
+بعد ما يصير اختراق للـ corona radiata بفعل الـ
+
+308
+00:22:11,820 --> 00:22:16,100
+sperm الـ sperm مباشرة بعمل search على الـ
+
+309
+00:22:16,100 --> 00:22:22,200
+receptor و بتتصل مع الـ Zoonopelucida من خلال الـ
+
+310
+00:22:22,200 --> 00:22:25,860
+receptor الـ Zoonopelucida by mean of the plasma
+
+311
+00:22:25,860 --> 00:22:29,830
+membrane of the sperm headSpermatozoa binds
+
+312
+00:22:29,830 --> 00:22:34,170
+specifically to the silica acid molecule that is
+
+313
+00:22:34,170 --> 00:22:37,170
+attached with the polypeptide core of the
+
+314
+00:22:37,170 --> 00:22:41,130
+zoonopelucida molecule بمعنى آخر أنه عشان يصير
+
+315
+00:22:41,130 --> 00:22:45,230
+penetration للـOocyte أو للـZoonopelucida لازم ال
+
+316
+00:22:45,230 --> 00:22:50,870
+sperm ينسك في منطقة معينةلا تتواجد إلا في الـ
+
+317
+00:22:50,870 --> 00:22:55,250
+zoonabulucida 3 تسمى الـ silica acid molecule يعني
+
+318
+00:22:55,250 --> 00:23:01,490
+كأن الـ sperm متخصص بالارتباط بالـ silica acid
+
+319
+00:23:01,490 --> 00:23:09,270
+molecule الموجود في zoonabulucida 3 والذي مرتبط
+
+320
+00:23:09,270 --> 00:23:11,570
+بالـ polypeptide core of zoonabulucida 3 بشكل
+
+321
+00:23:11,570 --> 00:23:16,180
+أساسيبشكل أساسي موجودة في أو مرتبط بهذا الـ Silic
+
+322
+00:23:16,180 --> 00:23:20,480
+Acid في الـ Poly-Tied Core of Zoonopelucid-3
+
+323
+00:23:20,480 --> 00:23:24,520
+ميكيول on the surface of sperm head are specific
+
+324
+00:23:24,520 --> 00:23:28,160
+binding site of Zoonopelucid-3 sperm receptor on
+
+325
+00:23:28,160 --> 00:23:31,640
+the Zoonopelucid So what is the meaning of this
+
+326
+00:23:31,640 --> 00:23:38,530
+paragraph؟ ببساطة إن الـ spermبيبحث عن منطقة في
+
+327
+00:23:38,530 --> 00:23:41,910
+الـ Zoonabolista 3 فقط لغير هي عبارة عن الـ
+
+328
+00:23:41,910 --> 00:23:45,930
+Receptor لأنها تحتوي على مادة يختص فيها ولا يتعرف
+
+329
+00:23:45,930 --> 00:23:49,870
+إلا عليها لـ sperm مثلا تسمى Silic Acid، هذا الـ
+
+330
+00:23:49,870 --> 00:23:52,890
+Silic Acid الـ attachment و الـ polypeptide core
+
+331
+00:23:52,890 --> 00:23:56,100
+الموجود في الـ Zoonabolistaيعني تشتغل هذه المنطقة
+
+332
+00:23:56,100 --> 00:24:01,220
+كـ Receptor وهي موجودة هيرقبط فيها ب sperm تمهيدة
+
+333
+00:24:01,220 --> 00:24:06,540
+لعملية إفراز الإنزيمات الهاضمة للـ Zona Pellucida
+
+334
+00:24:06,540 --> 00:24:11,840
+طيب، before binding to the Zona Pellucida ممانيا
+
+335
+00:24:11,840 --> 00:24:15,100
+الـ spermatozoa undergo to a chromosomal reaction
+
+336
+00:24:15,100 --> 00:24:21,250
+طبعا جابلما يتم الإرتباط و قبل ما يصل إلى الـ
+
+337
+00:24:21,250 --> 00:24:24,650
+receptor و يصير فيه إرتباط بشكل واضح و قوي لازم
+
+338
+00:24:24,650 --> 00:24:28,830
+يصير عند الـ sperm full active و لشأن يصير الـ
+
+339
+00:24:28,830 --> 00:24:33,530
+sperm full active يعني لازم يكون قادر على إفراز
+
+340
+00:24:33,530 --> 00:24:38,740
+الإنزيمات المقلوبة تحت مصطلحأكروزومال reaction تب
+
+341
+00:24:38,740 --> 00:24:41,160
+شو بيصير في الـ acrosomal reaction؟ وشو هو الـ
+
+342
+00:24:41,160 --> 00:24:43,840
+acrosomal reaction؟ الـ acrosomal reaction سلسلة
+
+343
+00:24:43,840 --> 00:24:47,020
+من التفاعلات بتصير على الـ acrosome الموجود في
+
+344
+00:24:47,020 --> 00:24:51,800
+مقدمة الـ head للـ sperm تمهيدا لإفراز محتويات الـ
+
+345
+00:24:51,800 --> 00:24:56,120
+physical التي تحتوي على الإنزيمات الغاضبة كيف
+
+346
+00:24:56,120 --> 00:25:00,780
+تبدأ؟ في البدايةفي بداية تطور الـ acrosome
+
+347
+00:25:00,780 --> 00:25:04,740
+reaction بيصير في عندي حاجة بيسموها massive influx
+
+348
+00:25:04,740 --> 00:25:07,100
+of calcium شو يعني massive؟ يعني without ATP
+
+349
+00:25:07,100 --> 00:25:11,620
+influx خروج، تدفق يعني كأنه الكالسيوم الموجود في
+
+350
+00:25:11,620 --> 00:25:14,360
+الـ head of the sperm أو الموجود في الـ acrosome
+
+351
+00:25:14,360 --> 00:25:22,280
+يخرج نحو الخارج بشكل تلقائي CA plus 2 through the
+
+352
+00:25:22,280 --> 00:25:26,410
+plasma membrane of the sperm headهذا البروسيز اللي
+
+353
+00:25:26,410 --> 00:25:30,570
+مقصود فيها influx أو influx كبير من الكالسيوم من
+
+354
+00:25:30,570 --> 00:25:36,630
+جهة إسبانيا يكون مصاحبه مباشرة influx للسوديوم و
+
+355
+00:25:36,630 --> 00:25:40,690
+efflux للهيدروجين يعني كأنه مجرد ما يبدأ ال
+
+356
+00:25:40,690 --> 00:25:47,180
+reaction الكالسيوم هيطلع من جهة إسبانياهيطلع معه
+
+357
+00:25:47,180 --> 00:25:51,760
+السوديوم بينما الهيدروجين هيدخل داخل الـ head of
+
+358
+00:25:51,760 --> 00:25:57,560
+spirit الخروج والتدفق influx والدخول efflux هذا
+
+359
+00:25:57,560 --> 00:26:01,600
+بيعمل increasing للـ intracellular pH this process
+
+360
+00:26:01,600 --> 00:26:06,780
+caused exocytosis of the acrosomal vesicle هذه
+
+361
+00:26:06,780 --> 00:26:09,580
+مهمة جدا، خروج الكالسوم، خروج السوديومودخول
+
+362
+00:26:09,580 --> 00:26:13,040
+الهيدروجين بيعمل زيادة في الـ intracellular بيقرش
+
+363
+00:26:13,040 --> 00:26:17,500
+الخاصة بالـ sperm مما يسمح ويسبب عيب نسميه
+
+364
+00:26:17,500 --> 00:26:22,360
+Exocytosis Exocytosis of acrosome vesicles يعني
+
+365
+00:26:22,360 --> 00:26:25,440
+خروج الـ acrosome في الـ vesicles تخدوا بالك اندو
+
+366
+00:26:25,440 --> 00:26:30,240
+تختلف عن إجزو اندو للداخل إجزو للخارج لأنه لازم
+
+367
+00:26:30,240 --> 00:26:33,900
+تطلع هذه الـ vesicles عشان تفرز محتوى عشان تدمر
+
+368
+00:26:33,900 --> 00:26:41,050
+الحواجز التي تمناها من الوصول إلى الواحدةطبعاً هذا
+
+369
+00:26:41,050 --> 00:26:49,870
+الوضع في إطلاق مجموعة من الانزينات اللاتك انزينات
+
+370
+00:26:49,870 --> 00:26:51,290
+اللاتك انزينات اللاتك انزينات اللاتك انزينات
+
+371
+00:26:51,290 --> 00:26:51,870
+اللاتك انزينات اللاتك انزينات اللاتك انزينات
+
+372
+00:26:51,870 --> 00:26:53,050
+اللاتك انزينات اللاتك انزينات اللاتك انزينات
+
+373
+00:26:53,050 --> 00:26:53,510
+اللاتك انزينات اللاتك انزينات اللاتك انزينات
+
+374
+00:26:53,510 --> 00:26:54,510
+اللاتك انزينات اللاتك انزينات اللاتك انزينات
+
+375
+00:26:54,510 --> 00:26:54,850
+اللاتك انزينات اللاتك انزينات اللاتك انزينات
+
+376
+00:26:54,850 --> 00:26:57,750
+اللاتك انزينات اللاتك انزينات اللاتك انزينات
+
+377
+00:26:57,750 --> 00:27:07,770
+اللاتك انزينات اللاتك انزينات اللاتك انزينات
+
+378
+00:27:07,770 --> 00:27:12,820
+اللاتوإفراز محتويات الـ acrosome اللي بنسميها
+
+379
+00:27:12,820 --> 00:27:16,280
+lithic enzyme أو degenerate enzyme أو licensed
+
+380
+00:27:16,280 --> 00:27:20,840
+enzyme يعني الانزيمات الغاضمة بشكل أساسي فبالتالي
+
+381
+00:27:20,840 --> 00:27:25,960
+مهم جدا أن تصير هذه العمليات علشان تبدأ ويبدأ ال
+
+382
+00:27:25,960 --> 00:27:30,880
+acrosome أن يفرز محتوى ماهي محتوياته؟ licensed
+
+383
+00:27:30,880 --> 00:27:34,240
+enzyme أو lithic enzyme penetration of the zona
+
+384
+00:27:34,240 --> 00:27:41,230
+pellucida بتصير بطريقتينالطريقة الأولى هي
+
+385
+00:27:41,230 --> 00:27:44,470
+إفراز الإنزيمات الطريقة التانية هي عبارة عن الـ
+
+386
+00:27:44,470 --> 00:27:47,090
+high active motility للـ sperm اللي بنسميها
+
+387
+00:27:47,090 --> 00:27:50,270
+hyperactivation .. hyperactivation .. هنشوفها و
+
+388
+00:27:50,270 --> 00:27:54,810
+اتكلمنا عنها المحاضرة السابقة أشهر الإنزيمات التي
+
+389
+00:27:54,810 --> 00:28:00,150
+تُفرَز خلال عملية الـ acrosome reaction هو إنزين
+
+390
+00:28:00,150 --> 00:28:04,760
+بنسميه الـ acrosinالـ Acrosin هو عبارة عن a serine
+
+391
+00:28:04,760 --> 00:28:08,440
+proteinase that is formed to the inner acrosome
+
+392
+00:28:08,440 --> 00:28:11,540
+membrane هو عبارة عن البروتينيز، عشان كده بسميه
+
+393
+00:28:11,540 --> 00:28:15,180
+Acrosin هو بروتينيز انزيم يحتوى على الـ Serine
+
+394
+00:28:15,180 --> 00:28:19,140
+موجود في الـ Acrosome membrane ومهم جدا في عملية
+
+395
+00:28:19,140 --> 00:28:22,140
+.. مرتبط في inner surface of Acrosome membrane
+
+396
+00:28:22,140 --> 00:28:26,520
+ومهم جدا في عملية ال penetration الـ Acrosin هل له
+
+397
+00:28:26,520 --> 00:28:31,040
+معلومات أخرى، تعريف آخر، مواصفات أخرى؟ بهمنيبرو
+
+398
+00:28:31,040 --> 00:28:36,320
+أكروزين عبارة عن endoprotease enzyme هو عبارة عن
+
+399
+00:28:36,320 --> 00:28:39,580
+endoprotease enzyme with terpsin-like for example
+
+400
+00:28:39,580 --> 00:28:44,420
+بيكون localized في الـ acrosome reaction الـ
+
+401
+00:28:44,420 --> 00:28:47,380
+enzymatic بيكون الـ activity تبعته بيكون inactive
+
+402
+00:28:47,380 --> 00:28:50,940
+طالما هو داخل الـ acrosome بيكون inactive على شكل
+
+403
+00:28:50,940 --> 00:28:57,260
+زيموجين برو أكروزين بمجرد ما يتحول ويتنشط بتتحول
+
+404
+00:28:57,260 --> 00:29:00,710
+من البرو أكروزين in active formأو زي الموجود in
+
+405
+00:29:00,710 --> 00:29:06,650
+active form إلى أكروزين في ال active form أو بيبدأ
+
+406
+00:29:06,650 --> 00:29:09,930
+ال action تبعه مهم جدا يكون داخل ال physical
+
+407
+00:29:09,930 --> 00:29:12,970
+الخاصة بالchromosome inactive علشان ما يعمل side
+
+408
+00:29:12,970 --> 00:29:19,470
+effect خلال عمل و تطور ال spirit هذه فكرة أو طريقة
+
+409
+00:29:19,470 --> 00:29:26,540
+شغل الأكروزين as a lithic enzyme صورة بتوضحالـ
+
+410
+00:29:26,540 --> 00:29:30,220
+event اللى ممكن تصير خلال ال fertilization هى في
+
+411
+00:29:30,220 --> 00:29:35,380
+عندى ال oocyte هى في عندى ال sperm ال sperm makes
+
+412
+00:29:35,380 --> 00:29:39,120
+contact with egg الخطوة الأولى ال acrosome طبعا
+
+413
+00:29:39,120 --> 00:29:42,080
+قولناها دى باللون الأخضر اللى بتكون دايما في مقدمة
+
+414
+00:29:42,080 --> 00:29:47,380
+رأس النطوة الذكية ال event رقم اتنين ان ال
+
+415
+00:29:47,380 --> 00:29:50,720
+acrosome react with زونابلوسيدا من خلال
+
+416
+00:29:50,720 --> 00:29:53,640
+زونابلوسيدا رقم تلاتة فبفرز ال lytic enzyme اللى
+
+417
+00:29:53,640 --> 00:29:57,910
+بتعمل على التدميريعني كأنه بيعمل عملية opening أو
+
+418
+00:29:57,910 --> 00:30:01,050
+holes في الـ Zoonapalus ده الـ acrosome reacts
+
+419
+00:30:01,050 --> 00:30:07,370
+with pre-vital space يعني هذا الـ space اللي احنا
+
+420
+00:30:07,370 --> 00:30:11,370
+شايفينه هذا الـ space اللونه زي لون الزهر الفاتح
+
+421
+00:30:11,370 --> 00:30:16,610
+بنتسميه pre-vital space طبعا هنا هيلاقي granules
+
+422
+00:30:16,610 --> 00:30:20,250
+بسيطة بنتسميها protein receptor هذا هيتصل فيها لـ
+
+423
+00:30:20,250 --> 00:30:24,340
+spermPlasma membrane of sperm and egg تبدأ تعمل
+
+424
+00:30:24,340 --> 00:30:27,580
+fusion مع بعض من البعض وبتدخل بس النواة الخاصة
+
+425
+00:30:27,580 --> 00:30:32,260
+بالـ sperm يعني بمعنى أخر النواة الخاصة بالـ sperm
+
+426
+00:30:32,260 --> 00:30:35,420
+هي التي تشارك في عملية ال fertilization كمان شوية،
+
+427
+00:30:35,420 --> 00:30:38,540
+حلاج الكلام يختلف، حلاج النواة والـ metacondria،
+
+428
+00:30:38,540 --> 00:30:44,320
+ويلها تفاصيل تانية خلّيني أشوف الفيديو اللي بتكلم
+
+429
+00:30:44,320 --> 00:30:49,000
+عن عملية ال fertilization وقريتها وأهم ال event
+
+430
+00:30:49,000 --> 00:30:50,280
+اللي ممكن تحصل خلالها
+
+431
+00:30:57,290 --> 00:31:01,210
+عندما يحدث الهجوم خلال التجارب، يتم دفع ما يقارب
+
+432
+00:31:01,210 --> 00:31:07,470
+200 مليون سبرم أو spermatozoa إلى الجلد. هم
+
+433
+00:31:07,470 --> 00:31:10,090
+يسافرون من خلال عصرهم، ويحركوا من خلال حركتين مثل
+
+434
+00:31:10,090 --> 00:31:14,850
+الـ whip أو الـ flagella، ومن ثم تدفعهم من خلال
+
+435
+00:31:14,850 --> 00:31:17,830
+عضلات عضلات عضلة عضلة عضلة عضلة عضلة عضلة عضلة
+
+436
+00:31:17,830 --> 00:31:18,530
+عضلة عضلة عضلة عضلة عضلة عضلة عضلة عضلة عضلة عضلة
+
+437
+00:31:18,530 --> 00:31:19,170
+عضلة عضلة عضلة عضلة عضلة عضلة عضلة عضلة عضلة عضلة
+
+438
+00:31:19,170 --> 00:31:24,710
+عضلة عضلة عضلة عضلة عضلة عضلة
+
+439
+00:31:24,710 --> 00:31:28,670
+عضلة عضلة عضلة عضلة عضلة عضقبل 200 سبيرمتازوه فقط
+
+440
+00:31:28,670 --> 00:31:32,810
+ستصل إلى الـ secondary oocyte في البرمجل و من هذه
+
+441
+00:31:32,810 --> 00:31:37,090
+فقط واحدة سوف تفردلها الفرداليزية لا يمكن أن تحدث
+
+442
+00:31:37,090 --> 00:31:42,870
+حتى أن اتجهت اتجاهين كتابة و اتجاه الاكراسومال
+
+443
+00:31:42,870 --> 00:31:48,470
+يمكن ان تأخذ ساعات كتابة و اتجاه الاكراسومال لا
+
+444
+00:31:48,470 --> 00:31:53,920
+يمكن ان تأخذ ساعاتولكن تحريكات من الجدران والجدران
+
+445
+00:31:53,920 --> 00:31:58,220
+التجاري تحرير ممكنات البلازمة اللي تقع في جدران
+
+446
+00:31:58,220 --> 00:32:03,280
+السفرمتازوة أو الـ Acrosome تتسبب في الممكنات تصبح
+
+447
+00:32:03,280 --> 00:32:07,420
+أكتر مطرقة، وهذا يساعد في تحريك السفرمتازوة لأحداث
+
+448
+00:32:07,420 --> 00:32:13,360
+الترتيب السفرمتازوة تصبح حيبر اكتر، فالجسدها تضرب
+
+449
+00:32:13,360 --> 00:32:18,220
+أكتر بشكل عادى، ومصادرها تتحرك من الجهدالـ
+
+450
+00:32:18,220 --> 00:32:20,880
+Capacitated Spermatozoa تتحرك من خلال كورونا
+
+451
+00:32:20,880 --> 00:32:22,780
+راديايدا، عبارة عن عبارة عن عبارة عن عبارة عن
+
+452
+00:32:22,780 --> 00:32:24,000
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+453
+00:32:24,000 --> 00:32:24,620
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+454
+00:32:24,620 --> 00:32:25,480
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+455
+00:32:25,480 --> 00:32:25,700
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+456
+00:32:25,700 --> 00:32:25,880
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+457
+00:32:25,880 --> 00:32:27,700
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+458
+00:32:27,700 --> 00:32:45,140
+عبارة عن عبارة
+
+459
+00:32:46,040 --> 00:32:51,240
+عندما يتم إطلاق مصادر الأنزيمات للـ Acrosome هذه
+
+460
+00:32:51,240 --> 00:32:54,180
+الأنزيمات ساعدت في تجهيز طريقة من خلال الـ
+
+461
+00:32:54,180 --> 00:32:57,460
+Zonopelucida يسمح بشركة الـ Spermatozoa بإدخال
+
+462
+00:32:57,460 --> 00:33:01,700
+مخطط الـ Perivitalin و تصل إلى مصادر الـ Plasma من
+
+463
+00:33:01,700 --> 00:33:05,920
+مصادر الـ Oocyte الثانوية التي تتعامل معها لتأكيد
+
+464
+00:33:05,920 --> 00:33:08,660
+أن فقط واحد من الـ Spermatozoa يدخل مصادر الـ
+
+465
+00:33:08,660 --> 00:33:13,410
+Zonopelucida و يتعامل مع مصادر الـ OocyteFusion of
+
+466
+00:33:13,410 --> 00:33:16,570
+the spermatozoan and oocyte membranes activates a
+
+467
+00:33:16,570 --> 00:33:21,090
+fast and a slow block to polyspermy. During fast
+
+468
+00:33:21,090 --> 00:33:24,450
+block to polyspermy, after fusion, the oocyte
+
+469
+00:33:24,450 --> 00:33:28,530
+membrane depolarizes, preventing other spermatozoa
+
+470
+00:33:28,530 --> 00:33:34,150
+from fusing with it. slow طبعا هنا بتكلم ما هي
+
+471
+00:33:34,150 --> 00:33:38,410
+الألية اللتي تستخدمها البويضة لمنع قلقيها بأكثر من
+
+472
+00:33:38,410 --> 00:33:43,160
+سبقين و هذا هنشرحه كمان شويةوالمجلد لـ Polyspermia
+
+473
+00:33:43,160 --> 00:33:48,400
+هو أيضًا مدفع من هذا الانتقال. في مجلد مدفع لـ
+
+474
+00:33:48,400 --> 00:33:51,840
+Polyspermia، يتم إطلاق حوار من الكالسيوم
+
+475
+00:33:51,840 --> 00:33:56,260
+الانتقالية، يسبب فيها عصباء صغيرة وكورتقالات تحت
+
+476
+00:33:56,260 --> 00:34:00,300
+عصباء الـ Oocyte Membrane لإطلاق مواصلتهم، يجعل
+
+477
+00:34:00,300 --> 00:34:05,100
+الـ ZP3 غير مفتوح ويجعل الـ Zonopelucida غير مدفع.
+
+478
+00:34:05,680 --> 00:34:09,180
+عندما يدخل الـ spermatozoon، يتعامل الـ Oocyte
+
+479
+00:34:09,180 --> 00:34:16,940
+ميوزس 2و يتطور إلى الـ female pronucleus في هذه
+
+480
+00:34:16,940 --> 00:34:21,060
+الوقت، الـ sperm يتطور إلى الـ male pronucleus و
+
+481
+00:34:21,060 --> 00:34:25,680
+الـ two pronuclei يتجمدوا لتصميم نوكليس ديبلويد أو
+
+482
+00:34:25,680 --> 00:34:30,820
+زيجوت طبعا
+
+483
+00:34:30,820 --> 00:34:37,120
+هنا اتكلم عن أكثر من حالة على سبيل المثال، اتكلم
+
+484
+00:34:37,120 --> 00:34:40,840
+عن الألية التي يتم في عملية ال penetrationدور الـ
+
+485
+00:34:40,840 --> 00:34:47,960
+ZE3 الموجودة بالوسداء كيف الـ oocyte تمنع التوقيع
+
+486
+00:34:47,960 --> 00:34:52,120
+نفسها بأكثر من sperm من خلال إفراز بعض المُركّبات
+
+487
+00:34:52,120 --> 00:34:57,620
+كيف يتكون الزيجات أيضًا طبعًا عملية منع التوقيع بـ
+
+488
+00:34:57,620 --> 00:35:01,340
+two sperm لها طريقتين سنتحدث عنهم واحدة سلوك واحدة
+
+489
+00:35:01,340 --> 00:35:05,640
+فصل سأشرحهم في الفيديو بشكل مقتصر وسنتحدث عنهم إن
+
+490
+00:35:05,640 --> 00:35:08,920
+شاء الله طبعًا
+
+491
+00:35:10,340 --> 00:35:18,520
+بعد اتفاق الـ Spermatozoa الوارثية
+
+492
+00:35:18,520 --> 00:35:21,380
+للمادة الوارثية في الـ site الخاص بالـ sperm في
+
+493
+00:35:21,380 --> 00:35:24,540
+الـ cytoplasm الخاص بالـ oocyte عشان يبدأ عملية
+
+494
+00:35:24,540 --> 00:35:27,560
+الاندماج ما بين الـ maternal و الـ maternal
+
+495
+00:35:27,560 --> 00:35:33,240
+nucleic acid في بعضهم بقول ليه و بعض العلماء هنا
+
+496
+00:35:33,240 --> 00:35:36,500
+فيه نقطة اختلاف Also, metachondria located in the
+
+497
+00:35:36,500 --> 00:35:39,900
+sperm neck enter the egg, they do not contribute
+
+498
+00:35:41,270 --> 00:35:44,750
+metachondrial complement of the zygote يعني في ناس
+
+499
+00:35:44,750 --> 00:35:47,710
+بتحكي و علماء بتقول أن الـ metachondria الموجودة
+
+500
+00:35:47,710 --> 00:35:52,150
+في الـ neck أو الخاصة بالـ sperm تدخل مع المادة
+
+501
+00:35:52,150 --> 00:35:57,610
+الوراثية داخل الـ cytoplasm الخاص بالـ oocyte ولكن
+
+502
+00:35:57,610 --> 00:36:01,670
+لا تساهم في تكوين الـ zygote هل هذا صحيح؟ لأن في
+
+503
+00:36:01,670 --> 00:36:04,310
+ناس تانية بتقول لك لأ مافي عندي metachondrial
+
+504
+00:36:04,310 --> 00:36:07,070
+paternal metachondrial دي يعني مافي حاجة اسمها
+
+505
+00:36:07,070 --> 00:36:09,890
+paternal metachondrial دي يعني ممكن ألجيها في
+
+506
+00:36:09,890 --> 00:36:13,990
+الجنين عشان كدهصار في عنده اختلاف هل الـ DNA الخاص
+
+507
+00:36:13,990 --> 00:36:17,470
+في الـ metacondria الموجود في الأجنة تتبع ال male
+
+508
+00:36:17,470 --> 00:36:21,190
+و لا يتبع ال female بمعنى أخر خاص بالأب paterna
+
+509
+00:36:21,190 --> 00:36:25,990
+ولا خاص بالأم materna وهذا كان نقطة خلاف كبير جدا
+
+510
+00:36:25,990 --> 00:36:30,570
+ما بين العلماء على هذا الموضوع ولكن الموضوع أنه في
+
+511
+00:36:30,570 --> 00:36:34,710
+حاجة اسمها autophage system بتعمل engulfing لل
+
+512
+00:36:34,710 --> 00:36:37,950
+paterna الميتاكندريا الدياني إن دخلت الcytoplasma
+
+513
+00:36:37,950 --> 00:36:41,120
+عشان كده جدا نادر ما بتشوفالـ Paternal
+
+514
+00:36:41,120 --> 00:36:45,100
+Mitochondrial في البشر الـ sperm تشغّل الـ
+
+515
+00:36:45,100 --> 00:36:50,760
+Centrosome اللي محتاجه لتنزيف الجسد موجود في
+
+516
+00:36:50,760 --> 00:36:56,540
+المادة الوراثية للأب بشكل أساسي مهم جدا علشان يكمل
+
+517
+00:36:56,540 --> 00:37:01,340
+عملية الغسام الخاصة بالجنين ال paternal
+
+518
+00:37:01,340 --> 00:37:04,620
+mitochondrial اللي حكينا فيها اندخلت خلال عملية ال
+
+519
+00:37:04,620 --> 00:37:09,640
+fertilization ووصلت لهاالـfertilized oocyte أو
+
+520
+00:37:09,640 --> 00:37:12,760
+الـCytoplasma الخاص بالـfertilized oocyte هتلاقي
+
+521
+00:37:12,760 --> 00:37:17,420
+مباشرة فيه إلها elimination يعني بتترد أو بيصيلها
+
+522
+00:37:17,420 --> 00:37:21,300
+breakdown أو degeneration بفعل إنزين يسميه
+
+523
+00:37:21,300 --> 00:37:27,660
+autophagocyte و لكن الطريقة و الميكنزم حتى الآن في
+
+524
+00:37:27,660 --> 00:37:29,300
+عندي limitation
+
+525
+00:37:34,850 --> 00:37:41,310
+المتوفرة عن هذا السبب أو عن هذه القالية The
+
+526
+00:37:41,310 --> 00:37:45,850
+inheritance of metachondria اتفق العلماء أن معظم
+
+527
+00:37:45,850 --> 00:37:49,070
+الـ metachondrial في أجسادنا inherited from mother
+
+528
+00:37:49,070 --> 00:37:54,270
+so this type of metachondrial is maternal
+
+529
+00:37:54,270 --> 00:37:57,310
+inheritance يعني معظم الـ metachondrial في أجسادنا
+
+530
+00:37:57,310 --> 00:38:02,350
+أصلها ومصدرها الأمبسيط الفيرتاليزيات البيتيرنا
+
+531
+00:38:02,350 --> 00:38:02,990
+البيتيرنا البيتيرنا البيتيرنا البيتيرنا البيتيرنا
+
+532
+00:38:02,990 --> 00:38:12,570
+البيتيرنا البيتيرنا البيتيرنا البيتيرنا
+
+533
+00:38:12,570 --> 00:38:14,250
+البيتيرنا البيتيرنا البيتيرنا البيتيرنا البيتيرنا
+
+534
+00:38:14,250 --> 00:38:16,110
+البيتيرنا البيتيرنا البيتيرنا البيتيرنا البيتيرنا
+
+535
+00:38:16,110 --> 00:38:19,210
+البيتيرنا
+
+536
+00:38:19,210 --> 00:38:23,750
+البيتيرنا
+
+537
+00:38:23,750 --> 00:38:26,610
+البيتيرنا البيتيرنا البيتيرنا البيتيرنا البيتيرنا
+
+538
+00:38:26,610 --> 00:38:27,990
+البيتيرنا البيتيرنا البيتيرنا البيتيرنا البيتيرنا
+
+539
+00:38:27,990 --> 00:38:28,050
+البيتيرنا البيتيرنا البيتيرنا البيتيرنا البيتيرنا
+
+540
+00:38:28,050 --> 00:38:31,190
+البيRecently, several authors have found that
+
+541
+00:38:31,190 --> 00:38:33,270
+sperm mitochondrial DNA remains in the
+
+542
+00:38:33,270 --> 00:38:36,750
+preimplantation embryo دراسات لما اتطورت و الأبحاث
+
+543
+00:38:36,750 --> 00:38:40,110
+وجدوا انه في مرحلة ال preimplantation embryo، ال
+
+544
+00:38:40,110 --> 00:38:43,870
+embryo جاب لعملية ال implantation وجدوا في عندي
+
+545
+00:38:43,870 --> 00:38:47,650
+بعض ال maternal mitochondrial DNA، طبعا هذا تفسيره
+
+546
+00:38:47,890 --> 00:38:51,710
+إنه قد يكون هناك خلل في الـ autophage system ففي
+
+547
+00:38:51,710 --> 00:38:55,450
+بعض الـ maternal metacondrial DNA scabbing وظلت
+
+548
+00:38:55,450 --> 00:38:58,630
+كما هي بدون ما يصيرها degeneration this finding ..
+
+549
+00:38:58,630 --> 00:39:02,570
+this finding suggest that spare metacondrial DNA
+
+550
+00:39:02,570 --> 00:39:05,850
+is replicated compound and is not actively
+
+551
+00:39:05,850 --> 00:39:09,930
+eliminated during infragenesis ببساطة جدا ماصارداش
+
+552
+00:39:09,930 --> 00:39:13,250
+من elimination بفعل خلل في ال autophage system
+
+553
+00:39:13,250 --> 00:39:17,880
+وصار هي replication فتضعفت بكمية موجودةفوجدناها
+
+554
+00:39:17,880 --> 00:39:22,180
+فيما بعد and the other explanation is that the
+
+555
+00:39:22,180 --> 00:39:25,840
+mitophage mechanism of the oocyte is defect ببساطة
+
+556
+00:39:25,840 --> 00:39:30,260
+جدا يعني في عدة سببين السبب الأول أن الميتوفاج ..
+
+557
+00:39:30,260 --> 00:39:33,380
+الميكنزم اللي سميته autophage الخاص بالـ oocyte
+
+558
+00:39:33,380 --> 00:39:37,280
+defect أو السبب التاني أنه صار لها replication
+
+559
+00:39:37,280 --> 00:39:40,800
+بكميات كبيرة جدا فأجد مابدتش تشغل ال autophage مش
+
+560
+00:39:40,800 --> 00:39:46,170
+هتقضي عليها فبالتالي هذاصارت حالة .. طبعا ما
+
+561
+00:39:46,170 --> 00:39:49,350
+اكتشفوهاش بكمية كبيرة جدا فقط حالات معدودة .. 7 ..
+
+562
+00:39:49,350 --> 00:39:52,730
+8 .. 9 حالات حتى الآن اكتشفوهم حتى بالـ whole
+
+563
+00:39:52,730 --> 00:39:55,830
+genome sequencing أو الـ DNA Sequencing لما عملوا
+
+564
+00:39:55,830 --> 00:39:59,370
+الـ DNA Sequencing للمادة الوراقية الموجودة في الـ
+
+565
+00:39:59,370 --> 00:40:01,530
+embryo لاجوا عندي تلاتة .. واحدة paternal ..
+
+566
+00:40:01,530 --> 00:40:04,430
+متكندرية واحدة maternal .. متكندرية واحدة paternal
+
+567
+00:40:04,430 --> 00:40:08,510
+.. متكندرية او لاجوا تلاتة .. واحدة خاصة بالأب ..
+
+568
+00:40:08,510 --> 00:40:11,610
+واحدة خاصة بالأم .. والتالتة فيما بعد اكتشفوا انها
+
+569
+00:40:11,610 --> 00:40:14,700
+عبارة عن paternal .. متكندرية .. DNA sequenceيعني
+
+570
+00:40:14,700 --> 00:40:18,700
+دليل أن الـ metacondria الموجودة في الـ spam قد
+
+571
+00:40:18,700 --> 00:40:24,480
+تتواجد و تضاعف و تبقى في الـ imprint كده هنخلص هذا
+
+572
+00:40:24,480 --> 00:40:27,680
+الموضوع و هذه المحاضرة عند هذا الحد ان شاء الله
+
+573
+00:40:27,680 --> 00:40:32,000
+على أمل أن نلتقي في المحاضرة القادمة ان شاء الله
+
+574
+00:40:32,000 --> 00:40:33,780
+تم تم في رعاية الله
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/g1I29Wemtw4_postprocess.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/g1I29Wemtw4_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..de81ae0d5fb44358d6f2fdad4158aa1d8f927e7f
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/g1I29Wemtw4_postprocess.srt
@@ -0,0 +1,1708 @@
+1
+00:00:01,160 --> 00:00:05,100
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:05,100 --> 00:00:10,240
+المرسلين سيدنا محمد وعلى آله وصحبه أجمعين طلابنا
+
+3
+00:00:10,240 --> 00:00:14,420
+الأعزاء أرجو من الله الكريم أن تكونوا جميعًا بخير
+
+4
+00:00:14,420 --> 00:00:19,540
+اليوم سوف نستكمل ما بدأنا فيه في المحاضرة السابقة
+
+5
+00:00:19,540 --> 00:00:23,920
+المتعلقة بالإكزي الـ Intracytoplasmic sperm
+
+6
+00:00:23,920 --> 00:00:27,900
+injection حيث تحدثنا في المحاضرة السابقة عن
+
+7
+00:00:27,900 --> 00:00:33,630
+القالية sperm catchingالـ Exidase preparation ما
+
+8
+00:00:33,630 --> 00:00:36,750
+هي المؤوقات التي تواجه الـ embryologies خلال عملية
+
+9
+00:00:36,750 --> 00:00:41,390
+الـ catching كيف يتم التخلص منها ما هي أنواع ال
+
+10
+00:00:41,390 --> 00:00:45,310
+media التي تستخدم زي الـ PVP media أو الـ high
+
+11
+00:00:45,310 --> 00:00:48,530
+viscous media أو ال solution media وما هي المادة
+
+12
+00:00:48,530 --> 00:00:52,710
+البديلة التي يمكن أن تستخدم بدل المينا الـ PVP وما
+
+13
+00:00:52,710 --> 00:00:57,210
+هو السبب الذي جعلها alternative media أو
+
+14
+00:00:57,210 --> 00:01:03,390
+alternative PVP mediaاليوم سوف نتكلم عن موضوع جديد
+
+15
+00:01:03,390 --> 00:01:08,510
+مكمل للموضوع السابق وهو آلية عمل sperm
+
+16
+00:01:08,510 --> 00:01:16,090
+immobilization كيف نفقد ال
+
+17
+00:01:16,090 --> 00:01:20,390
+sperm القدرة على الحركة تمهيدا لاستخدامه في عملية
+
+18
+00:01:20,390 --> 00:01:25,930
+الحطب once the spermatozoa is catch or pick up it
+
+19
+00:01:25,930 --> 00:01:29,630
+is appeared necessary immobilized before injection
+
+20
+00:01:29,890 --> 00:01:34,550
+بمعنى آخر طالما انت عملت catching ل3، 4، 5، 6
+
+21
+00:01:34,550 --> 00:01:39,230
+sperm هتستخدمهم في عملية ال injection لازم تخليهم
+
+22
+00:01:39,230 --> 00:01:43,910
+immobilized يعني immutable جبل ما تستخدمهم في
+
+23
+00:01:43,910 --> 00:01:48,170
+عملية ال injection فبالتالي كيف تتم عملية ال
+
+24
+00:01:48,170 --> 00:01:53,370
+immobilization for spermatozoa regardless of the
+
+25
+00:01:53,370 --> 00:01:57,550
+fact that under normal in vivo condition no sperm
+
+26
+00:01:57,550 --> 00:02:01,820
+tailwill be entered in the oocyte immobilized or
+
+27
+00:02:01,820 --> 00:02:06,140
+spermatozoa has two beneficial effects في الوضع
+
+28
+00:02:06,140 --> 00:02:08,800
+الطبيعي لما يصير injection في الوضع الطبيعي لل
+
+29
+00:02:08,800 --> 00:02:12,200
+oocyte و fertilization لل oocyte مافي tail يساهم
+
+30
+00:02:12,200 --> 00:02:15,920
+في عملية مافي tail بيدخل داخل الخلية يعني بمعنى
+
+31
+00:02:15,920 --> 00:02:19,300
+آخر ال tail له علاقة في ال fertilization إن كان
+
+32
+00:02:19,300 --> 00:02:24,020
+طبيعي ولكن ما بدخل داخل الخلية لأن ال
+
+33
+00:02:24,020 --> 00:02:28,690
+fertilization مهم جدا من أوامل وجودالـ tail علشان
+
+34
+00:02:28,690 --> 00:02:31,850
+يصير hyper activation زي ما شوفناها في المحاضرات
+
+35
+00:02:31,850 --> 00:02:37,150
+السابقة ولكن في الإجزي الـ tail مش مهم كتير لأن ال
+
+36
+00:02:37,150 --> 00:02:41,950
+injection سوف يحدث بفعل needed أول حاجة أقول ليه
+
+37
+00:02:41,950 --> 00:02:47,170
+شو هي أهمية ان نعمل sperm immobilization قبل عملية
+
+38
+00:02:47,170 --> 00:02:50,130
+ال injection any possible damage to the
+
+39
+00:02:50,130 --> 00:02:53,410
+cytoskeleton caused by a motile sperm is
+
+40
+00:02:53,410 --> 00:02:57,170
+theoretically ineligible بمعنى آخر أنا لما أجي
+
+41
+00:02:57,170 --> 00:03:02,370
+أعملImmobilization أو Cutting للتل كده أنا ألغيت
+
+42
+00:03:02,370 --> 00:03:06,870
+أي شكل غير طبيعي أو أي effect للشكل الغير طبيعي
+
+43
+00:03:06,870 --> 00:03:10,510
+الموجود في التل يعني مش هيأثر على عملية ال
+
+44
+00:03:10,510 --> 00:03:15,190
+fertilization The premobilization of the sperm
+
+45
+00:03:15,190 --> 00:03:20,270
+membrane will ensure that the soluble oocyte
+
+46
+00:03:20,270 --> 00:03:23,690
+activating factor immediately enter to the
+
+47
+00:03:23,690 --> 00:03:27,520
+oroplasma شو يعني الكلام هذا؟ببساطة بيقول ان انت
+
+48
+00:03:27,520 --> 00:03:31,840
+لما تجرح ال sperm tail لما تقطع ال sperm tail لما
+
+49
+00:03:31,840 --> 00:03:38,000
+تعمل sperm immobilization انت كده بتحفظ العوامل
+
+50
+00:03:38,000 --> 00:03:41,840
+السائلة الموجودة داخل ال spermatozoa انها تخرج
+
+51
+00:03:41,840 --> 00:03:46,760
+مباشرة بمجرد دخولها إلى ال oocyte ففيش عملية إعاقة
+
+52
+00:03:46,760 --> 00:03:49,940
+كده وهذه العملية مهمة جدا في عملية ال activation
+
+53
+00:03:49,940 --> 00:03:54,160
+لعملية ال fertilization وإتمامة بشكل صحيح وإتمام
+
+54
+00:03:54,160 --> 00:03:58,790
+عملية اندماجالنواة الذكرية مع النواة الأنثوية
+
+55
+00:03:58,790 --> 00:04:04,010
+لتكوين الزيجوت sperm immobilization usually
+
+56
+00:04:04,010 --> 00:04:09,110
+performed in the end of the tail او في منطقة
+
+57
+00:04:09,110 --> 00:04:13,070
+بنسميها المنتصف ما بين ال mid piece و ال tail يعني
+
+58
+00:04:13,070 --> 00:04:16,150
+انا ممكن اضرب ال sperm في منطقة tail و اجرح ال
+
+59
+00:04:16,150 --> 00:04:19,630
+tail تبعته اما في منهية ال tail ال tip of the tail
+
+60
+00:04:19,630 --> 00:04:24,030
+end of the tail او في منتصف المنطقة التي تفصل ما
+
+61
+00:04:24,030 --> 00:04:28,240
+بين ال headو ال tail أو ال mid piece و ال tail هي
+
+62
+00:04:28,240 --> 00:04:32,960
+عندي أكثر من منطقة من خلالها أنا بستطيع إعقاب ال
+
+63
+00:04:32,960 --> 00:04:36,900
+spermatozoa و فقدارها القدرة على الحركة طب في طرق
+
+64
+00:04:36,900 --> 00:04:40,900
+لهذه العملية أه في حوالي تلت طرق على سبيل المثال و
+
+65
+00:04:40,900 --> 00:04:44,720
+هي الطريقة الأكثر استخداما هي الطريقة بيسموها
+
+66
+00:04:44,720 --> 00:04:48,260
+mechanical method أو ال traditional method و بيبقى
+
+67
+00:04:48,260 --> 00:04:52,660
+ببساطة جدا أنا ده ال sperm شايفه normal من حيث ال
+
+68
+00:04:52,660 --> 00:04:57,150
+morphology و متحركعملتله catching من الhead نقلته
+
+69
+00:04:57,150 --> 00:05:01,010
+على ال PVP media تمام؟ عملت reduction ل ال
+
+70
+00:05:01,010 --> 00:05:04,450
+motility تبعته فبالتالي صار يتحرك ببطء شديد يعني
+
+71
+00:05:04,450 --> 00:05:07,970
+أنا بقدر أتحكم فيه أنا لو أجيت بطرف ال needle
+
+72
+00:05:07,970 --> 00:05:11,690
+الموج اللي خاصة بال injection ضغطت على ال tail
+
+73
+00:05:11,690 --> 00:05:17,030
+بشكل قوي أنا كإني بعمل عملية pressing أو عملية صحق
+
+74
+00:05:17,030 --> 00:05:21,430
+لل tail فكده أنا كإني قطعت ال tail ولو قطع جزء هذا
+
+75
+00:05:21,430 --> 00:05:25,060
+الطريقة الأولىطريقة تانية بتسميها more aggressive
+
+76
+00:05:25,060 --> 00:05:30,480
+mechanical وتحدث من خلال إن أنا باجي للمنطقة
+
+77
+00:05:30,480 --> 00:05:36,560
+الموجودة تحت المدبيس بقطع ال tail بضربه ضربتين
+
+78
+00:05:36,560 --> 00:05:41,380
+يعني قطين فبالتالي أنا كده إذا فشلت القطعة الأولى
+
+79
+00:05:41,380 --> 00:05:46,040
+لما كنت قطعته في القطعة التانية بنسبة 90% أو باجي
+
+80
+00:05:46,040 --> 00:05:50,120
+بقطعه قطع في ال end of the tail بعدين بقطعه في
+
+81
+00:05:50,120 --> 00:05:53,420
+منتصف المنطقة ما بين ال head و ال tailو نهاية التل
+
+82
+00:05:53,420 --> 00:05:56,760
+كده أنا قطعته كمان قطعته في بعضهم يقولك لأ أنا
+
+83
+00:05:56,760 --> 00:06:01,060
+بدرب و تلت ضربة .. ضربة في نهاية التل و ضربة في
+
+84
+00:06:01,060 --> 00:06:04,800
+منتصف المسافة ما بين ال head و نهاية التل و ضربة
+
+85
+00:06:04,800 --> 00:06:07,960
+في منتصف المسافة ما بين ال head و نهاية ال .. ال
+
+86
+00:06:07,960 --> 00:06:10,500
+mid piece و نهاية التل يعني كأنه بدرب و تلت ضربة
+
+87
+00:06:10,500 --> 00:06:15,800
+كأنه المنطقة من نهاية ال mid piece لتل بيقسمها ل 3
+
+88
+00:06:15,800 --> 00:06:19,880
+أقسام نهاية التل قسم و المنطقة المتباقيه قسمين
+
+89
+00:06:19,880 --> 00:06:24,660
+بضربتينطبعا هذه أقل استخداما الأكثر استخداما هي
+
+90
+00:06:24,660 --> 00:06:29,100
+الطريقة الأولى طريقة ال pressing انه انا بنهاية ال
+
+91
+00:06:29,100 --> 00:06:32,380
+injection needle بضغط على منتصف ال tail بقوة و
+
+92
+00:06:32,380 --> 00:06:36,420
+بسحب ال needle كإني بجرحه جرحه او بقطع و قطع و مش
+
+93
+00:06:36,420 --> 00:06:41,080
+لازم اقطع ال tail كامل اجرحه و يبين زي حرف زي
+
+94
+00:06:41,080 --> 00:06:44,120
+علامة الصح باللغة العربية زي علامة الصح باللغة
+
+95
+00:06:44,120 --> 00:06:49,080
+العربية هذه معناها ان والله انا كده جرحت ال tail
+
+96
+00:06:49,080 --> 00:06:54,270
+او فصلتيظهر بهذا الشكل يعني هاي باقي ال tail وهي
+
+97
+00:06:54,270 --> 00:06:56,650
+المنطقة القضاعتها لو انا افرض ان هي عند ال
+
+98
+00:06:56,650 --> 00:07:00,650
+spermatozoon بهذا الشكل انا ممكن اضرب ضربة هنا هاي
+
+99
+00:07:00,650 --> 00:07:03,590
+منطقة هاي طريقة طريقة تانية اضرب ضربة هنا و اضرب
+
+100
+00:07:03,590 --> 00:07:07,990
+كمان ضربتين هنا هاي طريقتين الاكثر استخداما هي
+
+101
+00:07:07,990 --> 00:07:11,790
+ضربة واحدة على نهاية ال tail بهذا الشكل هاي ال
+
+102
+00:07:11,790 --> 00:07:15,850
+spermatozoon هاي ال tail باجي بال injection needle
+
+103
+00:07:15,850 --> 00:07:20,150
+على المنطقة هذه و بضغط عليها ضغطة كاملة و بسحبفكدا
+
+104
+00:07:20,150 --> 00:07:25,270
+هيظهر لي ال sperm بهذا الشكل دليل ان انا قطعت ال
+
+105
+00:07:25,270 --> 00:07:30,610
+spermاترزوه هاد المنطقة هي عبارة عن منطقة القطع
+
+106
+00:07:30,610 --> 00:07:35,290
+طريقة تالتة بيستخدموها و هي طريقة ال aspiration او
+
+107
+00:07:35,290 --> 00:07:38,910
+ال repeated aspiration ان نعمل suction releasing
+
+108
+00:07:38,910 --> 00:07:43,570
+releasing suction و هكذا بشكل متتالي كدا انا بجبر
+
+109
+00:07:43,570 --> 00:07:50,520
+يصير في عملية damage ل ال sperm تالتأو بسرع في
+
+110
+00:07:50,520 --> 00:07:55,740
+عملية ال sperm immobilization طريقة الرابعة وهي
+
+111
+00:07:55,740 --> 00:08:00,180
+الأكثر استخداما حاليا بسبب تطور الأدوات المستخدمة
+
+112
+00:08:00,180 --> 00:08:05,060
+هي طريقة ال laser وهي ببساطة جدا في عندي مؤشر زي
+
+113
+00:08:05,060 --> 00:08:09,780
+مؤشر القناص بجيبه على منتصف الدل وبعمل click
+
+114
+00:08:09,780 --> 00:08:17,300
+بالماوس او بكنوب معين كنوب معين زر معين بطلق شعاع
+
+115
+00:08:17,300 --> 00:08:21,000
+laser هذا شعاع laser بدربالـ cell membrane فبعمل
+
+116
+00:08:21,000 --> 00:08:25,660
+قطع بسيط فيه أو بضرب الـ cell membrane الخاص بالـ
+
+117
+00:08:25,660 --> 00:08:29,740
+tail of spermatozoa فبعمل قطع في spermatozoa وهو
+
+118
+00:08:29,740 --> 00:08:33,740
+قطع بسيط مما يؤدي إلى عمل spermatozoa
+
+119
+00:08:33,740 --> 00:08:41,170
+immobilization طبعا في دراسات اختلفت فينتائجها ففي
+
+120
+00:08:41,170 --> 00:08:44,310
+دراسة جالت أنه more aggressive mechanical
+
+121
+00:08:44,310 --> 00:08:48,710
+immobilization process للـ Epidermal sperm تساعد
+
+122
+00:08:48,710 --> 00:08:52,490
+على زيادة ال fertilization rate بمعدل من 48 إلى 82
+
+123
+00:08:52,490 --> 00:08:56,450
+بس بشرط أنه تم تطبيقها على ال spermatozoa اللي جاي
+
+124
+00:08:56,450 --> 00:09:00,490
+من Epidermal يعني من التيسا أو البيسا مش ال
+
+125
+00:09:00,490 --> 00:09:05,780
+ejaculation العاديببساطة بجيب large drop فيها
+
+126
+00:09:05,780 --> 00:09:10,420
+حوالي 15 microliter من ال PVP media تركيزة 7%
+
+127
+00:09:10,420 --> 00:09:14,860
+بتكون في طريقة تانية طبعا بيستخدموها حاليا انه
+
+128
+00:09:14,860 --> 00:09:20,100
+بيجيب قطر تل قطرة حجمها 10 microliter و بيحط قطرة
+
+129
+00:09:20,100 --> 00:09:24,260
+جنبها هنشوفها كمان شوية في الصورة خليني أشرح
+
+130
+00:09:24,260 --> 00:09:27,260
+الصورة خليني أشرح الصورة أفضل على سبيل المثال
+
+131
+00:09:27,260 --> 00:09:31,710
+الصورةبقول ببساطة لو انا بدى استخدم عملية الـ
+
+132
+00:09:31,710 --> 00:09:35,910
+Laser أو عملية الـ Aggressive بجيب القطرة الأولى و
+
+133
+00:09:35,910 --> 00:09:42,930
+بحط فيها تقريبا 15 ميكرو ليتر من ال PVP media PVP
+
+134
+00:09:42,930 --> 00:09:50,250
+media و لازم يكون تركيزها 7% و هنا قطرة تانية
+
+135
+00:09:50,250 --> 00:09:56,370
+تركيزها كمية 10وبيجي بالـ needle بيعمل زي مسافة ما
+
+136
+00:09:56,370 --> 00:10:00,670
+بينهم أو زي قناة ما بينهم، canal الـ spermatozoa
+
+137
+00:10:00,670 --> 00:10:05,210
+بتتحرك في هذه الكئة طبعا بعد ما يضيف و يعمل
+
+138
+00:10:05,210 --> 00:10:08,150
+loading للـ spermatozoa في القطر الكبير الـ 15
+
+139
+00:10:08,150 --> 00:10:12,530
+microliter ال spermatozoa تميل إلى الحركة في اتجاه
+
+140
+00:10:12,530 --> 00:10:17,110
+حواف القطرة و هي تتحرك في اتجاه حواف القطرة هتلاقي
+
+141
+00:10:17,110 --> 00:10:22,320
+فتحة صغيرة هتبدأ تدخل من ال spermatozoaلما تدخل
+
+142
+00:10:22,320 --> 00:10:25,620
+الـ spermatozoa انت هتكون تستناها على البوابة
+
+143
+00:10:25,620 --> 00:10:29,440
+باستخدام ال injection needle أي sperm مدخل هتعمل
+
+144
+00:10:29,440 --> 00:10:34,280
+جرح للـ tail الخاص بيه بعدين تعمله aspiration او
+
+145
+00:10:34,280 --> 00:10:40,040
+تيجي توجه عليه مؤشر ال laser مطلق ال laser ال
+
+146
+00:10:40,040 --> 00:10:43,080
+laser shoot يا اما تضرب على منطقة ال tail
+
+147
+00:10:49,260 --> 00:10:53,160
+ممنوع احنا نستخدمها لأن فيها المادة الوراثية فانت
+
+148
+00:10:53,160 --> 00:10:57,760
+تضرب في منطقة ال tail ال tip of tail او منطقة ال
+
+149
+00:10:57,760 --> 00:11:02,820
+middle of tail بكون افضل كده انا بكون عملت تقليل
+
+150
+00:11:02,820 --> 00:11:07,460
+لل spermatozoa من حيث الحركة وعملت immobilization
+
+151
+00:11:07,460 --> 00:11:11,720
+باستخدام ال mechanical method او ال laser method
+
+152
+00:11:11,720 --> 00:11:16,040
+هذه او هذه طبعا ما بيستخدموا هذه الطريقةبستخدمه
+
+153
+00:11:16,040 --> 00:11:19,360
+إنه مباشرة باخد الـ spermatozoa مضيفة في قطرة
+
+154
+00:11:19,360 --> 00:11:23,980
+حجمها 15 microliter من الـ PVP media تركيزها 7%
+
+155
+00:11:23,980 --> 00:11:27,800
+وباجب ال injection needle باخد cutting للhead
+
+156
+00:11:27,800 --> 00:11:31,800
+بعدين بعمل aspiration لتلاتة spermatozoa مع بعض
+
+157
+00:11:31,800 --> 00:11:36,440
+بعدين بنقلهم إلى القطرة اللي موجودة في منتصف ال
+
+158
+00:11:36,440 --> 00:11:42,440
+bitter dish اللي سميته eggsy dish هذه الصورة بتبين
+
+159
+00:11:42,440 --> 00:11:47,790
+الكلام اللي اتكلمنا عنهببساطة جدا بقولني هاي انا
+
+160
+00:11:47,790 --> 00:11:52,290
+عندي ال sperm هذا normal form شكل لو منحسه ال head
+
+161
+00:11:52,290 --> 00:11:57,150
+و ال tail باجي بال injection needle هذه بقطع هذه
+
+162
+00:11:57,150 --> 00:12:00,590
+زي الإبرة شايفين هذه؟ هذه زي الإبرة نهايتها باجي
+
+163
+00:12:00,590 --> 00:12:06,110
+بقطع ال tail في المنتصف أو في نهاية ال tail بعدين
+
+164
+00:12:06,110 --> 00:12:10,100
+بعمله aspiration شوفوا في اختلاف هنافي المرة
+
+165
+00:12:10,100 --> 00:12:14,460
+الأولى لما نختار ال spermatozoa اللى بدى يعملهم in
+
+166
+00:12:14,460 --> 00:12:18,900
+mobilization عملهم suction من ال head لأنه لسه
+
+167
+00:12:18,900 --> 00:12:22,280
+متحرك بكمية كبيرة جدا فصعب يعمله suction و
+
+168
+00:12:22,280 --> 00:12:26,740
+aspiration من التل بعد ما عمله in mobilization صار
+
+169
+00:12:26,740 --> 00:12:30,740
+التل عديم الفائدة لايتحرك ال sperm فعمله
+
+170
+00:12:30,740 --> 00:12:35,680
+aspiration داخل ال injection needle باستخدام من
+
+171
+00:12:35,680 --> 00:12:41,000
+منطقة التلأضف إلى ذلك أنه لما تبدأ يعمل injection
+
+172
+00:12:41,000 --> 00:12:45,020
+مهم جدا أول ما يدخل داخل الخلية يدخل .. داخل
+
+173
+00:12:45,020 --> 00:12:48,260
+القصيد يدخل ال head of sperm مش ال tail of sperm
+
+174
+00:12:48,260 --> 00:12:53,100
+هذا طبعا مهم جدا علشان يسرع في عملية ال
+
+175
+00:12:53,100 --> 00:12:57,580
+fertilization هذه فكرة عملية ال sperm
+
+176
+00:12:57,580 --> 00:13:01,600
+immobilization كيف تتمس و كانت mechanical أو laser
+
+177
+00:13:01,600 --> 00:13:05,580
+أو حاجة بتسميها more aggressive أو عملية ال
+
+178
+00:13:05,580 --> 00:13:08,440
+aspiration repeated aspirationهنشوف الفيديو
+
+179
+00:13:08,440 --> 00:13:12,600
+المتعلق بهذا الكلام كيف نقوم بعمل إعقاب للـ
+
+180
+00:13:12,600 --> 00:13:17,840
+spermatozoa انتبهوا على الفيديو كويس خدوا
+
+181
+00:13:17,840 --> 00:13:21,240
+بالكوا دايما الحيوانات المتحركة الأكثر حركة أو
+
+182
+00:13:21,240 --> 00:13:25,860
+القدرة على الحركة بتكون على حواف القطرة طبعا هنا
+
+183
+00:13:26,640 --> 00:13:29,860
+اختار الـ spermatozoa وبعدين عملها افراغ في قطرة
+
+184
+00:13:29,860 --> 00:13:35,580
+جديدة وبدأ يعملهم immobilization من خلال عملية ضغط
+
+185
+00:13:35,580 --> 00:13:44,460
+وسحب على منطقة التل ضغط وسحب ثم aspiration ضغط على
+
+186
+00:13:44,460 --> 00:13:47,680
+منطقة التل سحب عشان يجرحها وبعدين يعملها
+
+187
+00:13:47,680 --> 00:13:54,810
+aspiration عشان تدخل داخل ال injection neededطيب،
+
+188
+00:13:54,810 --> 00:13:57,150
+كيف أنت أعمل selection للـ spermatozoa؟ هل كل الـ
+
+189
+00:13:57,150 --> 00:13:59,850
+spermatozoa الموجودة تمامًا، مية في المية و ممكن
+
+190
+00:13:59,850 --> 00:14:02,910
+أستخدمها في ال fertilization؟ يعني، okay أنا عملت
+
+191
+00:14:02,910 --> 00:14:07,150
+swarm up أو سيبك من ال swarm up، عند spermatozoa
+
+192
+00:14:07,150 --> 00:14:12,430
+عملتلها gradient، قدّتني في ال sperm كيف يمكن أن
+
+193
+00:14:12,430 --> 00:14:16,630
+نتأكد أن هذه الحيوانات المنوية تصلح لعملية الحق إن
+
+194
+00:14:16,630 --> 00:14:21,350
+ممكن يكون spermatozoa ميت، non-vital، non-life
+
+195
+00:14:21,350 --> 00:14:25,680
+sperm فبالتالي، مهم جدًا أعملselection for
+
+196
+00:14:25,680 --> 00:14:29,780
+spermatozoa زي ما عملنا selection للـ oocyte فقط
+
+197
+00:14:29,780 --> 00:14:33,980
+الـ oocyte اللي بتكون في second metaphase وهو الـ
+
+198
+00:14:33,980 --> 00:14:37,180
+second metaphase أو الـ metaphase الخاص بالـ
+
+199
+00:14:37,180 --> 00:14:40,400
+second metodic division هي التي تصلح لعملية الحقن،
+
+200
+00:14:40,400 --> 00:14:44,400
+فمهم جدا مهم جدا إن أشوف الـ spermatozoa تحت
+
+201
+00:14:44,400 --> 00:14:48,180
+الميكروسكوب على عدسة تكبير مية عشان أنا أقول والله
+
+202
+00:14:48,180 --> 00:14:53,350
+هذا ال sperm يصلح أو لا يصلح بعد كدهلازم اعمل
+
+203
+00:14:53,350 --> 00:14:57,050
+evaluation لل spermatozoa من حيث طول، من حيث حجم
+
+204
+00:14:57,050 --> 00:15:01,830
+ال head، من حيث طول ال tail، يعني مورفوليجيكال
+
+205
+00:15:01,830 --> 00:15:06,530
+يكونوا قبعيين 100% مافي عندي مشكلة لأن ال sperm
+
+206
+00:15:06,530 --> 00:15:10,490
+ممكن يكون طبيعي، مافي مشكلة، بس المادة الوراثية
+
+207
+00:15:10,490 --> 00:15:13,970
+فيها مشكلة طبعا هذا مش هنقدر نتعرف عليها بالطريقة
+
+208
+00:15:13,970 --> 00:15:16,430
+العادية، هنستخدم طريقة أخرى اسمها DNA
+
+209
+00:15:16,430 --> 00:15:21,300
+Fragmentationوهذه طريقة مخالقة، طريقة جديدة، نادر
+
+210
+00:15:21,300 --> 00:15:23,960
+ما يستخدموها عندنا ممكن مركز واحد هو اللي
+
+211
+00:15:23,960 --> 00:15:27,880
+بيستخدمها طريقة الـDNA Fragmentation فعلى سبيل
+
+212
+00:15:27,880 --> 00:15:31,020
+المثال، study report that Hyrunate receptor is
+
+213
+00:15:31,020 --> 00:15:34,560
+expressed in the mature spermatozoa only after
+
+214
+00:15:34,560 --> 00:15:37,760
+plasma membrane remodeling during spermatogenesis
+
+215
+00:15:37,760 --> 00:15:42,420
+and that Hyrunate is an ideal media for sperm
+
+216
+00:15:42,420 --> 00:15:46,880
+selection for exitوهذا حكيناها قبل كده كيف يمكن
+
+217
+00:15:46,880 --> 00:15:51,860
+استخدامها الهي لورينايت استخدمها في الشق الأول في
+
+218
+00:15:51,860 --> 00:15:55,400
+عملية ال immobilization أو عملية ال reduction لل
+
+219
+00:15:55,400 --> 00:15:58,860
+spare motility حاليا بقولك ممكن أنت كمان تستخدمها
+
+220
+00:15:58,860 --> 00:16:03,260
+في عملية ال spare selection زي ما استخدمناها في ال
+
+221
+00:16:03,260 --> 00:16:08,420
+swarm up أو في ال gradient centrifigation كيف أفرق
+
+222
+00:16:08,420 --> 00:16:11,480
+ما بين ال motile و ال non-motile spare؟ هذه الحتة
+
+223
+00:16:11,480 --> 00:16:15,840
+شوية حكينا فيها في مصابقولكن مهم أيضًا أدرجة في
+
+224
+00:16:15,840 --> 00:16:20,480
+هذه المنطقة لأنها تعتبر عملية مهمة يجب أن تقام
+
+225
+00:16:20,480 --> 00:16:24,940
+ويعمل بيها قبل ما أعمل immobilization لأي sperm إن
+
+226
+00:16:24,940 --> 00:16:29,460
+هذا ال sperm already live، already متعد، مش ساكن،
+
+227
+00:16:29,460 --> 00:16:34,760
+ممكن يكون ال sperm ساكن ولكن ميت طب أنا إيش بدي
+
+228
+00:16:34,760 --> 00:16:39,920
+منه؟ لازم يكون متعد ال sperm، live ال sperm هل
+
+229
+00:16:39,920 --> 00:16:43,280
+يمكن استخدام ال immobilization في عملية الحقن؟لا
+
+230
+00:16:43,280 --> 00:16:47,420
+يمكن استخدام الـ Immatile Sperm في عملية الحقن ولو
+
+231
+00:16:47,420 --> 00:16:50,380
+كان Normal Form من حيث Normal Morphology Normal
+
+232
+00:16:50,380 --> 00:16:55,440
+ممنوع استخدامه فبالتالي if they cannot distinction
+
+233
+00:16:55,440 --> 00:16:59,740
+between Immatile and non-viable sperm also
+
+234
+00:16:59,740 --> 00:17:03,220
+Immatile does not prevent viability ايش يعني
+
+235
+00:17:03,220 --> 00:17:06,900
+المعنى الكلام؟ مش كل sperm Immatile هو sperm مميت
+
+236
+00:17:06,900 --> 00:17:11,620
+فبالتالي ال Immatility لا تنفي الحياة ممكن يكون حي
+
+237
+00:17:11,920 --> 00:17:16,380
+يصلح لعملية الطلقاح الصناعي رغم أنه غير متحرك
+
+238
+00:17:16,380 --> 00:17:19,780
+فبالتالي أنا ممكن أستخدمه في هذه الحتة لأنه مهمنيش
+
+239
+00:17:19,780 --> 00:17:23,260
+مهمني أكون حي حتى لو أنه مش متعرض لأن أنا اللي
+
+240
+00:17:23,260 --> 00:17:26,560
+هأخرق البويضة أو أخترقها من خلال ال injection
+
+241
+00:17:26,560 --> 00:17:31,260
+needed فمهم يكون sperm life لكي أستخدمه في عملية
+
+242
+00:17:31,260 --> 00:17:36,380
+الحقن حتى لو كان غير متحرك فبالتالي ال trick هذه
+
+243
+00:17:36,380 --> 00:17:40,520
+ممكن أتغلب عليها بعدة أمور الأمر الأول طريقة ال
+
+244
+00:17:40,520 --> 00:17:43,860
+flexibilityماذا يعني flexibility؟ أشوف هل الـ
+
+245
+00:17:43,860 --> 00:17:49,020
+sperm tail إله flexible يعني بيقاوم الحركة اللي
+
+246
+00:17:49,020 --> 00:17:53,140
+ممكن تتوجهله يعني لو أنا حركت ال tail باستخدام ال
+
+247
+00:17:53,140 --> 00:17:58,000
+injection needle لأي sperm غير متحرك، هيتحرك معي
+
+248
+00:17:58,000 --> 00:18:03,100
+ال head هيتحرك في اتجاه مخالف لحركة ال tail ولكنهم
+
+249
+00:18:03,100 --> 00:18:06,120
+هيتحركوا كتلة واحدة، هذه إليها تعريف وهذه إليها
+
+250
+00:18:06,120 --> 00:18:09,900
+تعريف، هذه إليها تفسير وهذه إليها تفسير second ال
+
+251
+00:18:09,900 --> 00:18:14,050
+spermatozoafor example showing an elastic tail
+
+252
+00:18:14,050 --> 00:18:17,510
+when
+
+253
+00:18:17,510 --> 00:18:22,510
+we pressuring to the tail of a spermatozoa to be
+
+254
+00:18:22,510 --> 00:18:27,790
+more viable than those with more rigid ones بمعنى
+
+255
+00:18:27,790 --> 00:18:33,590
+آخر أنا لما أجي أحرك عند ال sperm أجي بطرف ال
+
+256
+00:18:33,590 --> 00:18:37,710
+needle أحرك ال tail الخاص بال sperm لو أنا ال tail
+
+257
+00:18:37,710 --> 00:18:47,710
+اتحرك معي بكل سهولةمعناه ال sperm life وبالتالي شو
+
+258
+00:18:47,710 --> 00:18:51,630
+يعني ال sperm life؟ لأن ال tail مرن لو ال sperm
+
+259
+00:18:51,630 --> 00:18:57,010
+dead هتجد ال tail very fixed، very rigid، مش
+
+260
+00:18:57,010 --> 00:19:01,050
+هيتحرك، مافيش فيه ليونة في الحركة فبالتالي هيتحرك
+
+261
+00:19:01,050 --> 00:19:05,150
+في اتجاه و ال tail هيتحرك في اتجاه آخر بينما لو
+
+262
+00:19:05,150 --> 00:19:10,430
+كان ال sperm حي هيتحرك كلهم ككتلة واحدة هنشوفها
+
+263
+00:19:10,430 --> 00:19:14,610
+كمان شوية بالصورةأضف إلى ذلك في حالة ال sperm الحي
+
+264
+00:19:14,610 --> 00:19:18,450
+هلاجي بمجرد أعمل touch لل sperm بنهاية ال
+
+265
+00:19:18,450 --> 00:19:22,890
+injection needle هيصير عملية rolling في نهاية ال
+
+266
+00:19:22,890 --> 00:19:27,110
+tail ال tail هيعمل rolling يعني التفاف ولو بسيط
+
+267
+00:19:27,110 --> 00:19:32,530
+جدا بخلاف ال sperm الميت هيكون عبارة عن street
+
+268
+00:19:32,530 --> 00:19:38,410
+line مش هيؤدي ولا رد فعل تذكركيف ممكن أن اتأكد
+
+269
+00:19:38,410 --> 00:19:41,770
+بفحص كتير حكينا فيه في مصابق اسمه الـ Hypo
+
+270
+00:19:41,770 --> 00:19:47,070
+Cosmetic Swelling Solution ان انا باخد هذا ال
+
+271
+00:19:47,070 --> 00:19:51,630
+sperm و بضيفه فيه Cosmetic Solution اذا والله
+
+272
+00:19:51,630 --> 00:19:56,150
+انتفخ التل معناه هذا ال sperm حي ماانتفخش هذا ال
+
+273
+00:19:56,150 --> 00:20:00,050
+sperm غير حي عشان كده بقول الجميط و ال functional
+
+274
+00:20:00,050 --> 00:20:04,310
+membranewill undergo swelling of the cytoplasmic
+
+275
+00:20:04,310 --> 00:20:08,510
+space and sperm till fiber will be colloid هذا
+
+276
+00:20:08,510 --> 00:20:13,430
+معناه بأن الـ sperm هي الـ sperm استجاب لاختلاف
+
+277
+00:20:13,430 --> 00:20:17,110
+الضغط الأسموذي إذا هذا ال sperm ممكن أخته أعمله
+
+278
+00:20:17,110 --> 00:20:21,910
+immobilization و أستخدمه في عملية الحقن هذه الصورة
+
+279
+00:20:21,910 --> 00:20:26,330
+بتتكلم عن الحوار اللي أنا حكيته قبل شوية هذا الـ
+
+280
+00:20:26,330 --> 00:20:31,010
+osmotic ribo osmotic swelling testكيف الـ sperm
+
+281
+00:20:31,010 --> 00:20:36,230
+ماتزوب تستجيب لاختلاف الضغط الأسموزي إذا كان ال
+
+282
+00:20:36,230 --> 00:20:40,390
+sperm live زي هذا الشكل و هذا الشكل و هذا الشكل و
+
+283
+00:20:40,390 --> 00:20:43,630
+هذا الشكل هدولة صار فيها عندك swelling أو صار فيها
+
+284
+00:20:43,630 --> 00:20:47,830
+عندك coil في نهاية ال sperm معناه هذا live الصورة
+
+285
+00:20:47,830 --> 00:20:51,970
+هذه رقم A اللي بدي أحكي عليها بتبينلي عملية الحركة
+
+286
+00:20:51,970 --> 00:20:56,290
+أنا هاي عند ال sperm هاي ال sperm بالشكل هذا أجيت
+
+287
+00:20:56,290 --> 00:21:00,620
+بنهاية ال needle أو ال injection needleو وضعتها في
+
+288
+00:21:00,620 --> 00:21:04,680
+نهاية ال sperm و بدأت اتحرك في اتجاه السهم لما
+
+289
+00:21:04,680 --> 00:21:09,100
+بدأت اتحرك في اتجاه السهم في نوع من انواع الليونة
+
+290
+00:21:09,100 --> 00:21:17,020
+في حركة ال sperm اضف إلى ذلك ان ال head اتحرك مع
+
+291
+00:21:17,020 --> 00:21:21,600
+حركة ال tail بحركة متناغمة اضف إلى ذلك ان ال tail
+
+292
+00:21:21,600 --> 00:21:27,580
+اخد التفاف بسيط على طرف ال injection needle معناه
+
+293
+00:21:27,580 --> 00:21:33,450
+في استجابةمن قبل الـ tail ال head و ال tail تحركت
+
+294
+00:21:33,450 --> 00:21:40,910
+كحركة و كتلة واحدة نجلة P بيها دي إذا كانت م tile
+
+295
+00:21:40,910 --> 00:21:46,010
+و non-life أنا أجيت وضعت ال injection needle في
+
+296
+00:21:46,010 --> 00:21:50,670
+نهاية ال tail و اتحركت لأعلى على سبيل المثال بلاجي
+
+297
+00:21:50,670 --> 00:21:55,050
+كل أنا راح أتحرك لأعلى ال head بنزل لأسفل كأنه
+
+298
+00:21:55,050 --> 00:22:01,950
+مافيش حركةواضحة خاصة فيهم مافيش حركة واضحة خاصة
+
+299
+00:22:01,950 --> 00:22:07,830
+فيهم مافيش استجابة من قبل ال tail مافي الليونة
+
+300
+00:22:07,830 --> 00:22:12,170
+التي ظهرت مافي الإنحناء اللذي ظهر في نهاية ال tail
+
+301
+00:22:12,170 --> 00:22:15,550
+زي الصورة الأولى طبعا هذه بيستخدموها بس لازم تكون
+
+302
+00:22:15,550 --> 00:22:18,910
+professional فيها شوية اتعلمت مرة و مرتين و تلاتة
+
+303
+00:22:18,910 --> 00:22:24,450
+هذه أكثر استخدام تاعة ال hypocosmotic طبعا في شغل
+
+304
+00:22:24,450 --> 00:22:30,600
+تانيةإنه في حركة A بمجرد أنا مارفع ال needle عن
+
+305
+00:22:30,600 --> 00:22:33,700
+نهاية ال tail ال tail برجع لوضعه الطبيعي برجع
+
+306
+00:22:33,700 --> 00:22:37,840
+لوضعه الطبيعي بينما هنا لأ بضله كما هو fixed مافي
+
+307
+00:22:37,840 --> 00:22:44,840
+أي ردد فعل فهذا معناه non-life وهذا معناه life في
+
+308
+00:22:44,840 --> 00:22:49,200
+طريقة تانية بستخدموها بستخدموا فيها ال laser وهو
+
+309
+00:22:49,200 --> 00:22:55,820
+ببساطة جدا بيجي بعمل إطلاق لقذيفة من ال laserبحجب
+
+310
+00:22:55,820 --> 00:23:00,680
+معين و بكمية معينة و بقوة معينة على نهاية ال tail
+
+311
+00:23:00,680 --> 00:23:05,340
+و ال sperm في داخلها إذا والله ال sperm non motile
+
+312
+00:23:05,340 --> 00:23:11,240
+ولكن life مباشرة هلاجي ال tail استجاب للطلقة و عمل
+
+313
+00:23:11,240 --> 00:23:16,760
+التفاف في النهاية معناه والله إن هذا ال sperm life
+
+314
+00:23:16,760 --> 00:23:22,300
+عشان كده استجاب لهذا الطلقة إذا كان ال sperm بعد
+
+315
+00:23:22,300 --> 00:23:26,320
+الطلقة شعار laser لم يستجيبفهذا معناه إن الـ sperm
+
+316
+00:23:26,320 --> 00:23:31,080
+dead، non-motile، non-life، لا يمكن أن يُستخدم في
+
+317
+00:23:31,080 --> 00:23:35,220
+الحقن الميجاري طبعاً هذه طريقة و هذه طريقة طبعاً
+
+318
+00:23:35,220 --> 00:23:39,200
+كل الطرق حالياً بتميل إلى استخدام الـ laser بيقولك
+
+319
+00:23:39,200 --> 00:23:45,240
+أسرع و أضمن ولكن هذا يعتمد على كمية الحالات اللي
+
+320
+00:23:45,240 --> 00:23:47,740
+بتيجي على المركز والله المركز بيجيله في الشهر 50
+
+321
+00:23:47,740 --> 00:23:52,260
+حالة هيجيب هذا الطريقة أسرعله و أضمنله بشكل كبير
+
+322
+00:23:52,260 --> 00:23:59,250
+جداًطبعاً هذا الشكل بيظهر لي مكونات عملية الحقن
+
+323
+00:23:59,250 --> 00:24:03,530
+المجهري أنا قلت على اليمين مباشرة عند الساعة تلاتة
+
+324
+00:24:03,530 --> 00:24:06,810
+في حاجة بنتسميها الـ Injection Needle هذه دائما
+
+325
+00:24:06,810 --> 00:24:10,450
+بتحمل الـ spermatozoa بداخلها عشان كده داخلها لازم
+
+326
+00:24:10,450 --> 00:24:14,250
+يكون مغسول بالـ PVP media على اليسار في اتجاه
+
+327
+00:24:14,250 --> 00:24:17,810
+الساعة تسعة في حاجة اسمها Holding Tube وهي اللي
+
+328
+00:24:17,810 --> 00:24:22,740
+بتعمل Fixing أو Fixation للـ Oocyteما بتخلّي الـ
+
+329
+00:24:22,740 --> 00:24:28,340
+Oocyte تتحرك دايما الـ Oocyte عند الحقن بأعملها
+
+330
+00:24:28,340 --> 00:24:31,940
+suction باستخدام ال holding pipet و لازم يكون ال
+
+331
+00:24:31,940 --> 00:24:36,320
+polar body في اتجاه الساعة 12 أو في اتجاه الساعة 6
+
+332
+00:24:36,320 --> 00:24:42,640
+و أبدأ عملية ال injection بشكل موازي لل holding
+
+333
+00:24:42,640 --> 00:24:45,980
+pipet لو أنا مافيش عندي pipet مافيش عندي عقون
+
+334
+00:24:45,980 --> 00:24:49,480
+Oocyte في هذا المكان و مافيش عندي spermatozoa وبدا
+
+335
+00:24:49,480 --> 00:24:53,590
+أتأكد هل ال injection needleموضوع بشكل صحيح هي و
+
+336
+00:24:53,590 --> 00:24:56,810
+ال holding pipet بقربهم بعض إذا دخلت ال injection
+
+337
+00:24:56,810 --> 00:25:01,730
+needle في الفجوة هذه الموجودة في مقدمة ال holding
+
+338
+00:25:01,730 --> 00:25:05,610
+pipet يعني تركيب ال two tools صحيح مية في المية
+
+339
+00:25:05,610 --> 00:25:11,510
+مافي عند مشكلة فببدأ أقدر أبدأ شغلي هذه فكرة عملية
+
+340
+00:25:11,510 --> 00:25:15,950
+ال injection و كيف تتم عملية ال injection مباشرة
+
+341
+00:25:15,950 --> 00:25:19,630
+تحت ال injection microscope أو ال X microscope
+
+342
+00:25:20,470 --> 00:25:25,490
+بأتأكد إن الـ egg موجودة على عدسة 200x بعدين بغير
+
+343
+00:25:25,490 --> 00:25:29,170
+ال field على عدسة 40x عشان يكون ال field أكثر وضوح
+
+344
+00:25:29,170 --> 00:25:35,750
+بعمل holding لبوايضة باستخدام ال holding by bit و
+
+345
+00:25:35,750 --> 00:25:41,450
+بخلّي ال polar body يا إما 66 أو 12 و باخد ال
+
+346
+00:25:41,450 --> 00:25:44,450
+injection needle اللي فيها ال sperm طبعا إذا كنت
+
+347
+00:25:44,450 --> 00:25:48,380
+متمرس في الحكاية هذهممكن تدخل داخل ال injection
+
+348
+00:25:48,380 --> 00:25:51,460
+needle تلاتة sperm عشان تحقن تلات بوايدات ولكن
+
+349
+00:25:51,460 --> 00:25:56,720
+الأفضل كل مرة لك تحقن بوايدة لازم يكون only single
+
+350
+00:25:56,720 --> 00:26:00,400
+sperm موجود داخل ال injection needle بعدين تيجي
+
+351
+00:26:00,400 --> 00:26:06,160
+تبدأ تحقن البوايدة بكل بدوء تتأكد إنك إنت اخترقت
+
+352
+00:26:06,160 --> 00:26:09,880
+الزونابليوسيدا أول ما تخترق الزونابليوسيدا و تحس
+
+353
+00:26:09,880 --> 00:26:12,800
+إنك دخلت ال cytoplasm طبعا لما تخترب من
+
+354
+00:26:12,800 --> 00:26:15,300
+الزونابليوسيدا و الcelmanpirale هتلاقي فيه مقاومة
+
+355
+00:26:15,990 --> 00:26:19,950
+أول ما تختارقها كإنك زي بلون و تم انفجاره، بالضبط
+
+356
+00:26:19,950 --> 00:26:23,690
+كذا تتأكد إنك موجود في الـ cytoplasm هتعمل suction
+
+357
+00:26:23,690 --> 00:26:28,570
+أو aspiration لكمية قليلة جدا من الـ sperm من الـ
+
+358
+00:26:28,570 --> 00:26:32,110
+cytoplasm الخاص بالـ oocyte بعد كده تعمل releasing
+
+359
+00:26:32,110 --> 00:26:36,670
+لهذه الكمية اللي سحبتها plus ال spermatozoo اللي
+
+360
+00:26:36,670 --> 00:26:42,490
+موجودة داخل ال injection needle طب شو هي .. لإيش
+
+361
+00:26:42,490 --> 00:26:45,850
+أنا بعملأسبيريشن للـ cytoplasm و لو كانت كمية قليل
+
+362
+00:26:45,850 --> 00:26:49,490
+جدا ليه شغل تاني؟ شغل الأولى إنه يتأكد إنه داخل
+
+363
+00:26:49,490 --> 00:26:53,890
+الـ oocyte شغل التانى عملية الـ aspiration لكمية
+
+364
+00:26:53,890 --> 00:26:56,650
+قليل جدا من الـcytoplasm تعمل زي دوامات بسيطة داخل
+
+365
+00:26:56,650 --> 00:27:01,710
+الخلية تنبيه خلية صار فيها اندفرتاليزيشن صار فيه
+
+366
+00:27:01,710 --> 00:27:04,410
+اختراق للزورة بلوسيدا يعني في عملية fertilization
+
+367
+00:27:04,410 --> 00:27:10,250
+قادمة تبدأ في استقبال الـ spermatozoa زي عملية
+
+368
+00:27:10,250 --> 00:27:17,300
+بنسميها activationهذه شكل الميكروسكوب الخاص بيه
+
+369
+00:27:17,300 --> 00:27:21,380
+طبعا هذه المناطق اللي احنا بنتكلم عنها طبعا هنا
+
+370
+00:27:21,380 --> 00:27:24,980
+بتكون ال injection needle هنا بتكون ال holder هذه
+
+371
+00:27:24,980 --> 00:27:29,620
+كلها المناطق و الأدوات اللي علاقة بال holder تحريك
+
+372
+00:27:29,620 --> 00:27:34,620
+لليمين اليسار للخلف للأمام للأعلى للأسفل الدغط
+
+373
+00:27:34,620 --> 00:27:37,220
+الداخل ال holder عملية ال suction عملية ال
+
+374
+00:27:37,220 --> 00:27:41,130
+releasing وهذه الموادو هذه الأدوات خاصة بالـ
+
+375
+00:27:41,130 --> 00:27:44,510
+injection needle تقديمها للأمام من الخلف عملية ال
+
+376
+00:27:44,510 --> 00:27:47,130
+releasing عملية ال suction عملية ال aspiration
+
+377
+00:27:47,130 --> 00:27:51,550
+تحريكها بشكل دائري أيضا يعني إلى حد ما إذا مافيش
+
+378
+00:27:51,550 --> 00:27:55,610
+stress just give بتصير القصة ولكن ال stress هو
+
+379
+00:27:55,610 --> 00:27:59,930
+اللي بيخلي فيها صعوبة إلى حد ما مهم جدا بعد عملية
+
+380
+00:27:59,930 --> 00:28:03,550
+releasing لل spermatozoon داخل ال oocyte أني أخرج
+
+381
+00:28:03,550 --> 00:28:08,610
+بكل سلاسة و بكل هدوء ما أعمل تهتك لل oocyte هذه
+
+382
+00:28:08,610 --> 00:28:12,220
+العمليةلو انت مبتدأ هتاخد لك دقيقة أو نصف دقيقة لو
+
+383
+00:28:12,220 --> 00:28:15,620
+انت بتشتغل في هذا المجال بشكل كبير جدا هتاخد فقط
+
+384
+00:28:15,620 --> 00:28:23,540
+تلاتين ثانية تلاتين ثانية القمر كله هياخد دقيقة
+
+385
+00:28:23,540 --> 00:28:23,560
+دقيقة دقيقة دقيقة دقيقة دقيقة دقيقة دقيقة دقيقة
+
+386
+00:28:23,560 --> 00:28:26,720
+دقيقة دقيقة دقيقة دقيقة دقيقة ديكتر ديكتر ديكتر
+
+387
+00:28:26,720 --> 00:28:26,800
+ديكتر ديكتر ديكتر ديكتر ديكتر ديكتر ديكتر ديكتر
+
+388
+00:28:26,800 --> 00:28:38,720
+ديكتر ديكتر ديكتر ديكتر ديكتر ديكت
+
+389
+00:28:38,900 --> 00:28:47,200
+400 هذا
+
+390
+00:28:47,200 --> 00:28:52,760
+الـ polar body الموجود عند العدسة عند الساعة 6 هذا
+
+391
+00:28:52,760 --> 00:28:56,800
+polar body هذا هو ال polar body المفروض أبعد عنه
+
+392
+00:28:56,800 --> 00:29:01,860
+أدخل طالما مقابل الفجوة هذه يعني أدخل من عند
+
+393
+00:29:01,860 --> 00:29:06,150
+الساعة 3 عشان أتأكد إن دخلت بالشكل الصحيحخُدوا
+
+394
+00:29:06,150 --> 00:29:08,770
+بالكوا هنا في partial denotation لأنه لو عمل الـ
+
+395
+00:29:08,770 --> 00:29:11,170
+denotation بشكل صحيح كل هذه ال accumulations
+
+396
+00:29:11,170 --> 00:29:14,250
+المفروض تروح تكون هاريا الخلية إلى حد ما
+
+397
+00:29:36,970 --> 00:29:40,630
+شايفين هذا الـ spermatozoa؟ قبل ما يدخل الخلية و
+
+398
+00:29:40,630 --> 00:29:43,490
+يعمل penetration للـ zoonablucida لازم ينسي ال
+
+399
+00:29:43,490 --> 00:29:46,970
+spermatozoa هذه البلون الفضي إلى أقرب منطقة من
+
+400
+00:29:46,970 --> 00:29:50,430
+فوية ال injection عشان ما ينزلش كتير PVP ميديا
+
+401
+00:29:50,430 --> 00:29:55,610
+داخل أوهوسايت كمان
+
+402
+00:29:55,610 --> 00:30:00,470
+هيصل لمنطقة هذه المفروض يصل لمنطقة هذه لحد ما
+
+403
+00:30:00,470 --> 00:30:06,600
+تمام؟ المفروض هلوجد يبدأ يخترق البويضة بكل هدوءبدا
+
+404
+00:30:06,600 --> 00:30:12,320
+يشعر فيه مقاومة بدا ياخد حرف ال U دليل انه موجود
+
+405
+00:30:12,320 --> 00:30:16,920
+على سطح ال spermatozoa سطح ال cytoplasm ال
+
+406
+00:30:16,920 --> 00:30:23,280
+cytoplasm بالمرن بدا يخترق .. يخترق .. هيصير
+
+407
+00:30:23,280 --> 00:30:28,100
+انفجار كده صار انفجار المفروض ياخد aspiration جزء
+
+408
+00:30:28,100 --> 00:30:32,980
+بسيط هياخد aspiration هيرتفع ال spermatozoa داخل
+
+409
+00:30:32,980 --> 00:30:33,640
+injection needle
+
+410
+00:30:36,400 --> 00:30:41,300
+بعدين يعمل releasing لـ spermatozoon علشان تبدأ
+
+411
+00:30:41,300 --> 00:30:46,140
+عملية ال fertilization شايفين؟ أعمل aspiration
+
+412
+00:30:46,140 --> 00:30:51,700
+ارتفع الـ cytoplasm ومعه ارتفع ال sperm بعد كده
+
+413
+00:30:51,700 --> 00:30:56,120
+هيعمل releasing علشان يتم عملية ال fertilization
+
+414
+00:31:08,630 --> 00:31:13,250
+كدا خلص عملية هاي الـ sperm الموجودة هذه كدا خلص
+
+415
+00:31:13,250 --> 00:31:17,430
+عملية ال fertilization بالشكل الكامل والشكل
+
+416
+00:31:17,430 --> 00:31:22,250
+المطلوب طبعا هذه الصورة بتوضح الخطوات نبدأ من A
+
+417
+00:31:22,250 --> 00:31:26,130
+الموجودة على اليسار holder injection needle
+
+418
+00:31:26,130 --> 00:31:33,270
+spermatozoa Oocyte في عندي polar body دخل لامس الـ
+
+419
+00:31:33,270 --> 00:31:37,710
+zona pellucidaبدا يضغط فيها بشواش تكوّن حرف الـ V
+
+420
+00:31:37,710 --> 00:31:44,270
+أو الـ U اخترق هاي الـ spermatozoa هيدخل إلى أقصى
+
+421
+00:31:44,270 --> 00:31:49,410
+مكان ممكن هيعمل aspiration بعدين يعمل releasing
+
+422
+00:31:49,410 --> 00:31:54,470
+بعد ما يعمل releasing هيسحب و يبدأ يخرج من نفس
+
+423
+00:31:54,470 --> 00:31:59,270
+المكان اللي دخل منه هيتأكد انه كده عمل عملية الحقد
+
+424
+00:31:59,270 --> 00:32:03,970
+بالشكل السليم والشكل المطلوبهنكتفي بهذا القدر في
+
+425
+00:32:03,970 --> 00:32:08,690
+هذه المحاضرة على أمل أن نكمل ما تبقى من محاضرة ال
+
+426
+00:32:08,690 --> 00:32:14,210
+Exe وعملية التلقيح و الحقنص مجهري في المحاضرات
+
+427
+00:32:14,210 --> 00:32:14,750
+القادمة
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/g1I29Wemtw4_raw.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/g1I29Wemtw4_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..58966308ba27f03b892ec52958dbdd2fa42a33bc
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/g1I29Wemtw4_raw.srt
@@ -0,0 +1,1712 @@
+1
+00:00:01,160 --> 00:00:05,100
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:05,100 --> 00:00:10,240
+المرسلين سيدنا محمد وعلى آله وصحبه أجمعين طلابنا
+
+3
+00:00:10,240 --> 00:00:14,420
+الأعزاء أرجو من الله الكريم أن تكونوا جميعًا بخير
+
+4
+00:00:14,420 --> 00:00:19,540
+اليوم سوف نستكمل ما بدأنا فيه في المحاضرة السابقة
+
+5
+00:00:19,540 --> 00:00:23,920
+المتعلقة بالإكزي الـ Intracytoplasmic sperm
+
+6
+00:00:23,920 --> 00:00:27,900
+injection حيث تحدثنا في المحاضرة السابقة عن
+
+7
+00:00:27,900 --> 00:00:33,630
+القالية sperm catchingالـ Exidase preparation ما
+
+8
+00:00:33,630 --> 00:00:36,750
+هي المؤوقات التي تواجه الـ embryologies خلال عملية
+
+9
+00:00:36,750 --> 00:00:41,390
+الـ catching كيف يتم التخلص منها ما هي أنواع ال
+
+10
+00:00:41,390 --> 00:00:45,310
+media التي تستخدم زي الـ PVP media أو الـ high
+
+11
+00:00:45,310 --> 00:00:48,530
+viscous media أو ال solution media وما هي المادة
+
+12
+00:00:48,530 --> 00:00:52,710
+البديلة التي يمكن أن تستخدم بدل المينا الـ PVP وما
+
+13
+00:00:52,710 --> 00:00:57,210
+هو السبب الذي جعلها alternative media أو
+
+14
+00:00:57,210 --> 00:01:03,390
+alternative PVP mediaاليوم سوف نتكلم عن موضوع جديد
+
+15
+00:01:03,390 --> 00:01:08,510
+مكمل للموضوع السابق وهو آلية عمل sperm
+
+16
+00:01:08,510 --> 00:01:16,090
+immobilization كيف نفقد ال
+
+17
+00:01:16,090 --> 00:01:20,390
+sperm القدرة على الحركة تمهيدا لاستخدامه في عملية
+
+18
+00:01:20,390 --> 00:01:25,930
+الحطب once the spermatozoa is catch or pick up it
+
+19
+00:01:25,930 --> 00:01:29,630
+is appeared necessary immobilized before injection
+
+20
+00:01:29,890 --> 00:01:34,550
+بمعنى آخر طالما انت عملت catching ل3، 4، 5، 6
+
+21
+00:01:34,550 --> 00:01:39,230
+sperm هتستخدمهم في عملية ال injection لازم تخليهم
+
+22
+00:01:39,230 --> 00:01:43,910
+immobilized يعني immutable جبل ما تستخدمهم في
+
+23
+00:01:43,910 --> 00:01:48,170
+عملية ال injection فبالتالي كيف تتم عملية ال
+
+24
+00:01:48,170 --> 00:01:53,370
+immobilization for spermatozoa regardless of the
+
+25
+00:01:53,370 --> 00:01:57,550
+fact that under normal in vivo condition no sperm
+
+26
+00:01:57,550 --> 00:02:01,820
+tailwill be entered in the oocyte immobilized or
+
+27
+00:02:01,820 --> 00:02:06,140
+spermatozoa has two beneficial effects في الوضع
+
+28
+00:02:06,140 --> 00:02:08,800
+الطبيعي لما يصير injection في الوضع الطبيعي لل
+
+29
+00:02:08,800 --> 00:02:12,200
+oocyte و fertilization لل oocyte مافي tail يساهم
+
+30
+00:02:12,200 --> 00:02:15,920
+في عملية مافي tail بيدخل داخل الخلية يعني بمعنى
+
+31
+00:02:15,920 --> 00:02:19,300
+آخر ال tail له علاقة في ال fertilization إن كان
+
+32
+00:02:19,300 --> 00:02:24,020
+طبيعي ولكن ما بدخل داخل الخلية لأن ال
+
+33
+00:02:24,020 --> 00:02:28,690
+fertilization مهم جدا من أوامل وجودالـ tail علشان
+
+34
+00:02:28,690 --> 00:02:31,850
+يصير hyper activation زي ما شوفناها في المحاضرات
+
+35
+00:02:31,850 --> 00:02:37,150
+السابقة ولكن في الإجزي الـ tail مش مهم كتير لأن ال
+
+36
+00:02:37,150 --> 00:02:41,950
+injection سوف يحدث بفعل needed أول حاجة أقول ليه
+
+37
+00:02:41,950 --> 00:02:47,170
+شو هي أهمية ان نعمل sperm immobilization قبل عملية
+
+38
+00:02:47,170 --> 00:02:50,130
+ال injection any possible damage to the
+
+39
+00:02:50,130 --> 00:02:53,410
+cytoskeleton caused by a motile sperm is
+
+40
+00:02:53,410 --> 00:02:57,170
+theoretically ineligible بمعنى آخر أنا لما أجي
+
+41
+00:02:57,170 --> 00:03:02,370
+أعملImmobilization أو Cutting للتل كده أنا ألغيت
+
+42
+00:03:02,370 --> 00:03:06,870
+أي شكل غير طبيعي أو أي effect للشكل الغير طبيعي
+
+43
+00:03:06,870 --> 00:03:10,510
+الموجود في التل يعني مش هيأثر على عملية ال
+
+44
+00:03:10,510 --> 00:03:15,190
+fertilization The premobilization of the sperm
+
+45
+00:03:15,190 --> 00:03:20,270
+membrane will ensure that the soluble oocyte
+
+46
+00:03:20,270 --> 00:03:23,690
+activating factor immediately enter to the
+
+47
+00:03:23,690 --> 00:03:27,520
+oroplasma شو يعني الكلام هذا؟ببساطة بيقول ان انت
+
+48
+00:03:27,520 --> 00:03:31,840
+لما تجرح ال sperm tail لما تقطع ال sperm tail لما
+
+49
+00:03:31,840 --> 00:03:38,000
+تعمل sperm immobilization انت كده بتحفظ العوامل
+
+50
+00:03:38,000 --> 00:03:41,840
+السائلة الموجودة داخل ال spermatozoa انها تخرج
+
+51
+00:03:41,840 --> 00:03:46,760
+مباشرة بمجرد دخولها إلى ال oocyte ففيش عملية إعاقة
+
+52
+00:03:46,760 --> 00:03:49,940
+كده وهذه العملية مهمة جدا في عملية ال activation
+
+53
+00:03:49,940 --> 00:03:54,160
+لعملية ال fertilization وإتمامة بشكل صحيح وإتمام
+
+54
+00:03:54,160 --> 00:03:58,790
+عملية اندماجالنواة الذكرية مع النواة الأنثوية
+
+55
+00:03:58,790 --> 00:04:04,010
+لتكوين الزيجوت sperm immobilization usually
+
+56
+00:04:04,010 --> 00:04:09,110
+performed in the end of the tail او في منطقة
+
+57
+00:04:09,110 --> 00:04:13,070
+بنسميها المنتصف ما بين ال mid piece و ال tail يعني
+
+58
+00:04:13,070 --> 00:04:16,150
+انا ممكن اضرب ال sperm في منطقة tail و اجرح ال
+
+59
+00:04:16,150 --> 00:04:19,630
+tail تبعته اما في منهية ال tail ال tip of the tail
+
+60
+00:04:19,630 --> 00:04:24,030
+end of the tail او في منتصف المنطقة التي تفصل ما
+
+61
+00:04:24,030 --> 00:04:28,240
+بين ال headو ال tail أو ال mid piece و ال tail هي
+
+62
+00:04:28,240 --> 00:04:32,960
+عندي أكثر من منطقة من خلالها أنا بستطيع إعقاب ال
+
+63
+00:04:32,960 --> 00:04:36,900
+spermatozoa و فقدارها القدرة على الحركة طب في طرق
+
+64
+00:04:36,900 --> 00:04:40,900
+لهذه العملية أه في حوالي تلت طرق على سبيل المثال و
+
+65
+00:04:40,900 --> 00:04:44,720
+هي الطريقة الأكثر استخداما هي الطريقة بيسموها
+
+66
+00:04:44,720 --> 00:04:48,260
+mechanical method أو ال traditional method و بيبقى
+
+67
+00:04:48,260 --> 00:04:52,660
+ببساطة جدا أنا ده ال sperm شايفه normal من حيث ال
+
+68
+00:04:52,660 --> 00:04:57,150
+morphology و متحركعملتله catching من الhead نقلته
+
+69
+00:04:57,150 --> 00:05:01,010
+على ال PVP media تمام؟ عملت reduction ل ال
+
+70
+00:05:01,010 --> 00:05:04,450
+motility تبعته فبالتالي صار يتحرك ببطء شديد يعني
+
+71
+00:05:04,450 --> 00:05:07,970
+أنا بقدر أتحكم فيه أنا لو أجيت بطرف ال needle
+
+72
+00:05:07,970 --> 00:05:11,690
+الموج اللي خاصة بال injection ضغطت على ال tail
+
+73
+00:05:11,690 --> 00:05:17,030
+بشكل قوي أنا كإني بعمل عملية pressing أو عملية صحق
+
+74
+00:05:17,030 --> 00:05:21,430
+لل tail فكده أنا كإني قطعت ال tail ولو قطع جزء هذا
+
+75
+00:05:21,430 --> 00:05:25,060
+الطريقة الأولىطريقة تانية بتسميها more aggressive
+
+76
+00:05:25,060 --> 00:05:30,480
+mechanical وتحدث من خلال إن أنا باجي للمنطقة
+
+77
+00:05:30,480 --> 00:05:36,560
+الموجودة تحت المدبيس بقطع ال tail بضربه ضربتين
+
+78
+00:05:36,560 --> 00:05:41,380
+يعني قطين فبالتالي أنا كده إذا فشلت القطعة الأولى
+
+79
+00:05:41,380 --> 00:05:46,040
+لما كنت قطعته في القطعة التانية بنسبة 90% أو باجي
+
+80
+00:05:46,040 --> 00:05:50,120
+بقطعه قطع في ال end of the tail بعدين بقطعه في
+
+81
+00:05:50,120 --> 00:05:53,420
+منتصف المنطقة ما بين ال head و ال tailو نهاية التل
+
+82
+00:05:53,420 --> 00:05:56,760
+كده أنا قطعته كمان قطعته في بعضهم يقولك لأ أنا
+
+83
+00:05:56,760 --> 00:06:01,060
+بدرب و تلت ضربة .. ضربة في نهاية التل و ضربة في
+
+84
+00:06:01,060 --> 00:06:04,800
+منتصف المسافة ما بين ال head و نهاية التل و ضربة
+
+85
+00:06:04,800 --> 00:06:07,960
+في منتصف المسافة ما بين ال head و نهاية ال .. ال
+
+86
+00:06:07,960 --> 00:06:10,500
+mid piece و نهاية التل يعني كأنه بدرب و تلت ضربة
+
+87
+00:06:10,500 --> 00:06:15,800
+كأنه المنطقة من نهاية ال mid piece لتل بيقسمها ل 3
+
+88
+00:06:15,800 --> 00:06:19,880
+أقسام نهاية التل قسم و المنطقة المتباقيه قسمين
+
+89
+00:06:19,880 --> 00:06:24,660
+بضربتينطبعا هذه أقل استخداما الأكثر استخداما هي
+
+90
+00:06:24,660 --> 00:06:29,100
+الطريقة الأولى طريقة ال pressing انه انا بنهاية ال
+
+91
+00:06:29,100 --> 00:06:32,380
+injection needle بضغط على منتصف ال tail بقوة و
+
+92
+00:06:32,380 --> 00:06:36,420
+بسحب ال needle كإني بجرحه جرحه او بقطع و قطع و مش
+
+93
+00:06:36,420 --> 00:06:41,080
+لازم اقطع ال tail كامل اجرحه و يبين زي حرف زي
+
+94
+00:06:41,080 --> 00:06:44,120
+علامة الصح باللغة العربية زي علامة الصح باللغة
+
+95
+00:06:44,120 --> 00:06:49,080
+العربية هذه معناها ان والله انا كده جرحت ال tail
+
+96
+00:06:49,080 --> 00:06:54,270
+او فصلتيظهر بهذا الشكل يعني هاي باقي ال tail وهي
+
+97
+00:06:54,270 --> 00:06:56,650
+المنطقة القضاعتها لو انا افرض ان هي عند ال
+
+98
+00:06:56,650 --> 00:07:00,650
+spermatozoon بهذا الشكل انا ممكن اضرب ضربة هنا هاي
+
+99
+00:07:00,650 --> 00:07:03,590
+منطقة هاي طريقة طريقة تانية اضرب ضربة هنا و اضرب
+
+100
+00:07:03,590 --> 00:07:07,990
+كمان ضربتين هنا هاي طريقتين الاكثر استخداما هي
+
+101
+00:07:07,990 --> 00:07:11,790
+ضربة واحدة على نهاية ال tail بهذا الشكل هاي ال
+
+102
+00:07:11,790 --> 00:07:15,850
+spermatozoon هاي ال tail باجي بال injection needle
+
+103
+00:07:15,850 --> 00:07:20,150
+على المنطقة هذه و بضغط عليها ضغطة كاملة و بسحبفكدا
+
+104
+00:07:20,150 --> 00:07:25,270
+هيظهر لي ال sperm بهذا الشكل دليل ان انا قطعت ال
+
+105
+00:07:25,270 --> 00:07:30,610
+spermاترزوه هاد المنطقة هي عبارة عن منطقة القطع
+
+106
+00:07:30,610 --> 00:07:35,290
+طريقة تالتة بيستخدموها و هي طريقة ال aspiration او
+
+107
+00:07:35,290 --> 00:07:38,910
+ال repeated aspiration ان نعمل suction releasing
+
+108
+00:07:38,910 --> 00:07:43,570
+releasing suction و هكذا بشكل متتالي كدا انا بجبر
+
+109
+00:07:43,570 --> 00:07:50,520
+يصير في عملية damage ل ال sperm تالتأو بسرع في
+
+110
+00:07:50,520 --> 00:07:55,740
+عملية ال sperm immobilization طريقة الرابعة وهي
+
+111
+00:07:55,740 --> 00:08:00,180
+الأكثر استخداما حاليا بسبب تطور الأدوات المستخدمة
+
+112
+00:08:00,180 --> 00:08:05,060
+هي طريقة ال laser وهي ببساطة جدا في عندي مؤشر زي
+
+113
+00:08:05,060 --> 00:08:09,780
+مؤشر القناص بجيبه على منتصف الدل وبعمل click
+
+114
+00:08:09,780 --> 00:08:17,300
+بالماوس او بكنوب معين كنوب معين زر معين بطلق شعاع
+
+115
+00:08:17,300 --> 00:08:21,000
+laser هذا شعاع laser بدربالـ cell membrane فبعمل
+
+116
+00:08:21,000 --> 00:08:25,660
+قطع بسيط فيه أو بضرب الـ cell membrane الخاص بالـ
+
+117
+00:08:25,660 --> 00:08:29,740
+tail of spermatozoa فبعمل قطع في spermatozoa وهو
+
+118
+00:08:29,740 --> 00:08:33,740
+قطع بسيط مما يؤدي إلى عمل spermatozoa
+
+119
+00:08:33,740 --> 00:08:41,170
+immobilization طبعا في دراسات اختلفت فينتائجها ففي
+
+120
+00:08:41,170 --> 00:08:44,310
+دراسة جالت أنه more aggressive mechanical
+
+121
+00:08:44,310 --> 00:08:48,710
+immobilization process للـ Epidermal sperm تساعد
+
+122
+00:08:48,710 --> 00:08:52,490
+على زيادة ال fertilization rate بمعدل من 48 إلى 82
+
+123
+00:08:52,490 --> 00:08:56,450
+بس بشرط أنه تم تطبيقها على ال spermatozoa اللي جاي
+
+124
+00:08:56,450 --> 00:09:00,490
+من Epidermal يعني من التيسا أو البيسا مش ال
+
+125
+00:09:00,490 --> 00:09:05,780
+ejaculation العاديببساطة بجيب large drop فيها
+
+126
+00:09:05,780 --> 00:09:10,420
+حوالي 15 microliter من ال PVP media تركيزة 7%
+
+127
+00:09:10,420 --> 00:09:14,860
+بتكون في طريقة تانية طبعا بيستخدموها حاليا انه
+
+128
+00:09:14,860 --> 00:09:20,100
+بيجيب قطر تل قطرة حجمها 10 microliter و بيحط قطرة
+
+129
+00:09:20,100 --> 00:09:24,260
+جنبها هنشوفها كمان شوية في الصورة خليني أشرح
+
+130
+00:09:24,260 --> 00:09:27,260
+الصورة خليني أشرح الصورة أفضل على سبيل المثال
+
+131
+00:09:27,260 --> 00:09:31,710
+الصورةبقول ببساطة لو انا بدى استخدم عملية الـ
+
+132
+00:09:31,710 --> 00:09:35,910
+Laser أو عملية الـ Aggressive بجيب القطرة الأولى و
+
+133
+00:09:35,910 --> 00:09:42,930
+بحط فيها تقريبا 15 ميكرو ليتر من ال PVP media PVP
+
+134
+00:09:42,930 --> 00:09:50,250
+media و لازم يكون تركيزها 7% و هنا قطرة تانية
+
+135
+00:09:50,250 --> 00:09:56,370
+تركيزها كمية 10وبيجي بالـ needle بيعمل زي مسافة ما
+
+136
+00:09:56,370 --> 00:10:00,670
+بينهم أو زي قناة ما بينهم، canal الـ spermatozoa
+
+137
+00:10:00,670 --> 00:10:05,210
+بتتحرك في هذه الكئة طبعا بعد ما يضيف و يعمل
+
+138
+00:10:05,210 --> 00:10:08,150
+loading للـ spermatozoa في القطر الكبير الـ 15
+
+139
+00:10:08,150 --> 00:10:12,530
+microliter ال spermatozoa تميل إلى الحركة في اتجاه
+
+140
+00:10:12,530 --> 00:10:17,110
+حواف القطرة و هي تتحرك في اتجاه حواف القطرة هتلاقي
+
+141
+00:10:17,110 --> 00:10:22,320
+فتحة صغيرة هتبدأ تدخل من ال spermatozoaلما تدخل
+
+142
+00:10:22,320 --> 00:10:25,620
+الـ spermatozoa انت هتكون تستناها على البوابة
+
+143
+00:10:25,620 --> 00:10:29,440
+باستخدام ال injection needle أي sperm مدخل هتعمل
+
+144
+00:10:29,440 --> 00:10:34,280
+جرح للـ tail الخاص بيه بعدين تعمله aspiration او
+
+145
+00:10:34,280 --> 00:10:40,040
+تيجي توجه عليه مؤشر ال laser مطلق ال laser ال
+
+146
+00:10:40,040 --> 00:10:43,080
+laser shoot يا اما تضرب على منطقة ال tail
+
+147
+00:10:49,260 --> 00:10:53,160
+ممنوع احنا نستخدمها لأن فيها المادة الوراثية فانت
+
+148
+00:10:53,160 --> 00:10:57,760
+تضرب في منطقة ال tail ال tip of tail او منطقة ال
+
+149
+00:10:57,760 --> 00:11:02,820
+middle of tail بكون افضل كده انا بكون عملت تقليل
+
+150
+00:11:02,820 --> 00:11:07,460
+لل spermatozoa من حيث الحركة وعملت immobilization
+
+151
+00:11:07,460 --> 00:11:11,720
+باستخدام ال mechanical method او ال laser method
+
+152
+00:11:11,720 --> 00:11:16,040
+هذه او هذه طبعا ما بيستخدموا هذه الطريقةبستخدمه
+
+153
+00:11:16,040 --> 00:11:19,360
+إنه مباشرة باخد الـ spermatozoa مضيفة في قطرة
+
+154
+00:11:19,360 --> 00:11:23,980
+حجمها 15 microliter من الـ PVP media تركيزها 7%
+
+155
+00:11:23,980 --> 00:11:27,800
+وباجب ال injection needle باخد cutting للhead
+
+156
+00:11:27,800 --> 00:11:31,800
+بعدين بعمل aspiration لتلاتة spermatozoa مع بعض
+
+157
+00:11:31,800 --> 00:11:36,440
+بعدين بنقلهم إلى القطرة اللي موجودة في منتصف ال
+
+158
+00:11:36,440 --> 00:11:42,440
+bitter dish اللي سميته eggsy dish هذه الصورة بتبين
+
+159
+00:11:42,440 --> 00:11:47,790
+الكلام اللي اتكلمنا عنهببساطة جدا بقولني هاي انا
+
+160
+00:11:47,790 --> 00:11:52,290
+عندي ال sperm هذا normal form شكل لو منحسه ال head
+
+161
+00:11:52,290 --> 00:11:57,150
+و ال tail باجي بال injection needle هذه بقطع هذه
+
+162
+00:11:57,150 --> 00:12:00,590
+زي الإبرة شايفين هذه؟ هذه زي الإبرة نهايتها باجي
+
+163
+00:12:00,590 --> 00:12:06,110
+بقطع ال tail في المنتصف أو في نهاية ال tail بعدين
+
+164
+00:12:06,110 --> 00:12:10,100
+بعمله aspiration شوفوا في اختلاف هنافي المرة
+
+165
+00:12:10,100 --> 00:12:14,460
+الأولى لما نختار ال spermatozoa اللى بدى يعملهم in
+
+166
+00:12:14,460 --> 00:12:18,900
+mobilization عملهم suction من ال head لأنه لسه
+
+167
+00:12:18,900 --> 00:12:22,280
+متحرك بكمية كبيرة جدا فصعب يعمله suction و
+
+168
+00:12:22,280 --> 00:12:26,740
+aspiration من التل بعد ما عمله in mobilization صار
+
+169
+00:12:26,740 --> 00:12:30,740
+التل عديم الفائدة لايتحرك ال sperm فعمله
+
+170
+00:12:30,740 --> 00:12:35,680
+aspiration داخل ال injection needle باستخدام من
+
+171
+00:12:35,680 --> 00:12:41,000
+منطقة التلأضف إلى ذلك أنه لما تبدأ يعمل injection
+
+172
+00:12:41,000 --> 00:12:45,020
+مهم جدا أول ما يدخل داخل الخلية يدخل .. داخل
+
+173
+00:12:45,020 --> 00:12:48,260
+القصيد يدخل ال head of sperm مش ال tail of sperm
+
+174
+00:12:48,260 --> 00:12:53,100
+هذا طبعا مهم جدا علشان يسرع في عملية ال
+
+175
+00:12:53,100 --> 00:12:57,580
+fertilization هذه فكرة عملية ال sperm
+
+176
+00:12:57,580 --> 00:13:01,600
+immobilization كيف تتمس و كانت mechanical أو laser
+
+177
+00:13:01,600 --> 00:13:05,580
+أو حاجة بتسميها more aggressive أو عملية ال
+
+178
+00:13:05,580 --> 00:13:08,440
+aspiration repeated aspirationهنشوف الفيديو
+
+179
+00:13:08,440 --> 00:13:12,600
+المتعلق بهذا الكلام كيف نقوم بعمل إعقاب للـ
+
+180
+00:13:12,600 --> 00:13:17,840
+spermatozoa انتبهوا على الفيديو كويس خدوا
+
+181
+00:13:17,840 --> 00:13:21,240
+بالكوا دايما الحيوانات المتحركة الأكثر حركة أو
+
+182
+00:13:21,240 --> 00:13:25,860
+القدرة على الحركة بتكون على حواف القطرة طبعا هنا
+
+183
+00:13:26,640 --> 00:13:29,860
+اختار الـ spermatozoa وبعدين عملها افراغ في قطرة
+
+184
+00:13:29,860 --> 00:13:35,580
+جديدة وبدأ يعملهم immobilization من خلال عملية ضغط
+
+185
+00:13:35,580 --> 00:13:44,460
+وسحب على منطقة التل ضغط وسحب ثم aspiration ضغط على
+
+186
+00:13:44,460 --> 00:13:47,680
+منطقة التل سحب عشان يجرحها وبعدين يعملها
+
+187
+00:13:47,680 --> 00:13:54,810
+aspiration عشان تدخل داخل ال injection neededطيب،
+
+188
+00:13:54,810 --> 00:13:57,150
+كيف أنت أعمل selection للـ spermatozoa؟ هل كل الـ
+
+189
+00:13:57,150 --> 00:13:59,850
+spermatozoa الموجودة تمامًا، مية في المية و ممكن
+
+190
+00:13:59,850 --> 00:14:02,910
+أستخدمها في ال fertilization؟ يعني، okay أنا عملت
+
+191
+00:14:02,910 --> 00:14:07,150
+swarm up أو سيبك من ال swarm up، عند spermatozoa
+
+192
+00:14:07,150 --> 00:14:12,430
+عملتلها gradient، قدّتني في ال sperm كيف يمكن أن
+
+193
+00:14:12,430 --> 00:14:16,630
+نتأكد أن هذه الحيوانات المنوية تصلح لعملية الحق إن
+
+194
+00:14:16,630 --> 00:14:21,350
+ممكن يكون spermatozoa ميت، non-vital، non-life
+
+195
+00:14:21,350 --> 00:14:25,680
+sperm فبالتالي، مهم جدًا أعملselection for
+
+196
+00:14:25,680 --> 00:14:29,780
+spermatozoa زي ما عملنا selection للـ oocyte فقط
+
+197
+00:14:29,780 --> 00:14:33,980
+الـ oocyte اللي بتكون في second metaphase وهو الـ
+
+198
+00:14:33,980 --> 00:14:37,180
+second metaphase أو الـ metaphase الخاص بالـ
+
+199
+00:14:37,180 --> 00:14:40,400
+second metodic division هي التي تصلح لعملية الحقن،
+
+200
+00:14:40,400 --> 00:14:44,400
+فمهم جدا مهم جدا إن أشوف الـ spermatozoa تحت
+
+201
+00:14:44,400 --> 00:14:48,180
+الميكروسكوب على عدسة تكبير مية عشان أنا أقول والله
+
+202
+00:14:48,180 --> 00:14:53,350
+هذا ال sperm يصلح أو لا يصلح بعد كدهلازم اعمل
+
+203
+00:14:53,350 --> 00:14:57,050
+evaluation لل spermatozoa من حيث طول، من حيث حجم
+
+204
+00:14:57,050 --> 00:15:01,830
+ال head، من حيث طول ال tail، يعني مورفوليجيكال
+
+205
+00:15:01,830 --> 00:15:06,530
+يكونوا قبعيين 100% مافي عندي مشكلة لأن ال sperm
+
+206
+00:15:06,530 --> 00:15:10,490
+ممكن يكون طبيعي، مافي مشكلة، بس المادة الوراثية
+
+207
+00:15:10,490 --> 00:15:13,970
+فيها مشكلة طبعا هذا مش هنقدر نتعرف عليها بالطريقة
+
+208
+00:15:13,970 --> 00:15:16,430
+العادية، هنستخدم طريقة أخرى اسمها DNA
+
+209
+00:15:16,430 --> 00:15:21,300
+Fragmentationوهذه طريقة مخالقة، طريقة جديدة، نادر
+
+210
+00:15:21,300 --> 00:15:23,960
+ما يستخدموها عندنا ممكن مركز واحد هو اللي
+
+211
+00:15:23,960 --> 00:15:27,880
+بيستخدمها طريقة الـDNA Fragmentation فعلى سبيل
+
+212
+00:15:27,880 --> 00:15:31,020
+المثال، study report that Hyrunate receptor is
+
+213
+00:15:31,020 --> 00:15:34,560
+expressed in the mature spermatozoa only after
+
+214
+00:15:34,560 --> 00:15:37,760
+plasma membrane remodeling during spermatogenesis
+
+215
+00:15:37,760 --> 00:15:42,420
+and that Hyrunate is an ideal media for sperm
+
+216
+00:15:42,420 --> 00:15:46,880
+selection for exitوهذا حكيناها قبل كده كيف يمكن
+
+217
+00:15:46,880 --> 00:15:51,860
+استخدامها الهي لورينايت استخدمها في الشق الأول في
+
+218
+00:15:51,860 --> 00:15:55,400
+عملية ال immobilization أو عملية ال reduction لل
+
+219
+00:15:55,400 --> 00:15:58,860
+spare motility حاليا بقولك ممكن أنت كمان تستخدمها
+
+220
+00:15:58,860 --> 00:16:03,260
+في عملية ال spare selection زي ما استخدمناها في ال
+
+221
+00:16:03,260 --> 00:16:08,420
+swarm up أو في ال gradient centrifigation كيف أفرق
+
+222
+00:16:08,420 --> 00:16:11,480
+ما بين ال motile و ال non-motile spare؟ هذه الحتة
+
+223
+00:16:11,480 --> 00:16:15,840
+شوية حكينا فيها في مصابقولكن مهم أيضًا أدرجة في
+
+224
+00:16:15,840 --> 00:16:20,480
+هذه المنطقة لأنها تعتبر عملية مهمة يجب أن تقام
+
+225
+00:16:20,480 --> 00:16:24,940
+ويعمل بيها قبل ما أعمل immobilization لأي sperm إن
+
+226
+00:16:24,940 --> 00:16:29,460
+هذا ال sperm already live، already متعد، مش ساكن،
+
+227
+00:16:29,460 --> 00:16:34,760
+ممكن يكون ال sperm ساكن ولكن ميت طب أنا إيش بدي
+
+228
+00:16:34,760 --> 00:16:39,920
+منه؟ لازم يكون متعد ال sperm، live ال sperm هل
+
+229
+00:16:39,920 --> 00:16:43,280
+يمكن استخدام ال immobilization في عملية الحقن؟لا
+
+230
+00:16:43,280 --> 00:16:47,420
+يمكن استخدام الـ Immatile Sperm في عملية الحقن ولو
+
+231
+00:16:47,420 --> 00:16:50,380
+كان Normal Form من حيث Normal Morphology Normal
+
+232
+00:16:50,380 --> 00:16:55,440
+ممنوع استخدامه فبالتالي if they cannot distinction
+
+233
+00:16:55,440 --> 00:16:59,740
+between Immatile and non-viable sperm also
+
+234
+00:16:59,740 --> 00:17:03,220
+Immatile does not prevent viability ايش يعني
+
+235
+00:17:03,220 --> 00:17:06,900
+المعنى الكلام؟ مش كل sperm Immatile هو sperm مميت
+
+236
+00:17:06,900 --> 00:17:11,620
+فبالتالي ال Immatility لا تنفي الحياة ممكن يكون حي
+
+237
+00:17:11,920 --> 00:17:16,380
+يصلح لعملية الطلقاح الصناعي رغم أنه غير متحرك
+
+238
+00:17:16,380 --> 00:17:19,780
+فبالتالي أنا ممكن أستخدمه في هذه الحتة لأنه مهمنيش
+
+239
+00:17:19,780 --> 00:17:23,260
+مهمني أكون حي حتى لو أنه مش متعرض لأن أنا اللي
+
+240
+00:17:23,260 --> 00:17:26,560
+هأخرق البويضة أو أخترقها من خلال ال injection
+
+241
+00:17:26,560 --> 00:17:31,260
+needed فمهم يكون sperm life لكي أستخدمه في عملية
+
+242
+00:17:31,260 --> 00:17:36,380
+الحقن حتى لو كان غير متحرك فبالتالي ال trick هذه
+
+243
+00:17:36,380 --> 00:17:40,520
+ممكن أتغلب عليها بعدة أمور الأمر الأول طريقة ال
+
+244
+00:17:40,520 --> 00:17:43,860
+flexibilityماذا يعني flexibility؟ أشوف هل الـ
+
+245
+00:17:43,860 --> 00:17:49,020
+sperm tail إله flexible يعني بيقاوم الحركة اللي
+
+246
+00:17:49,020 --> 00:17:53,140
+ممكن تتوجهله يعني لو أنا حركت ال tail باستخدام ال
+
+247
+00:17:53,140 --> 00:17:58,000
+injection needle لأي sperm غير متحرك، هيتحرك معي
+
+248
+00:17:58,000 --> 00:18:03,100
+ال head هيتحرك في اتجاه مخالف لحركة ال tail ولكنهم
+
+249
+00:18:03,100 --> 00:18:06,120
+هيتحركوا كتلة واحدة، هذه إليها تعريف وهذه إليها
+
+250
+00:18:06,120 --> 00:18:09,900
+تعريف، هذه إليها تفسير وهذه إليها تفسير second ال
+
+251
+00:18:09,900 --> 00:18:14,050
+spermatozoafor example showing an elastic tail
+
+252
+00:18:14,050 --> 00:18:17,510
+when
+
+253
+00:18:17,510 --> 00:18:22,510
+we pressuring to the tail of a spermatozoa to be
+
+254
+00:18:22,510 --> 00:18:27,790
+more viable than those with more rigid ones بمعنى
+
+255
+00:18:27,790 --> 00:18:33,590
+آخر أنا لما أجي أحرك عند ال sperm أجي بطرف ال
+
+256
+00:18:33,590 --> 00:18:37,710
+needle أحرك ال tail الخاص بال sperm لو أنا ال tail
+
+257
+00:18:37,710 --> 00:18:47,710
+اتحرك معي بكل سهولةمعناه ال sperm life وبالتالي شو
+
+258
+00:18:47,710 --> 00:18:51,630
+يعني ال sperm life؟ لأن ال tail مرن لو ال sperm
+
+259
+00:18:51,630 --> 00:18:57,010
+dead هتجد ال tail very fixed، very rigid، مش
+
+260
+00:18:57,010 --> 00:19:01,050
+هيتحرك، مافيش فيه ليونة في الحركة فبالتالي هيتحرك
+
+261
+00:19:01,050 --> 00:19:05,150
+في اتجاه و ال tail هيتحرك في اتجاه آخر بينما لو
+
+262
+00:19:05,150 --> 00:19:10,430
+كان ال sperm حي هيتحرك كلهم ككتلة واحدة هنشوفها
+
+263
+00:19:10,430 --> 00:19:14,610
+كمان شوية بالصورةأضف إلى ذلك في حالة ال sperm الحي
+
+264
+00:19:14,610 --> 00:19:18,450
+هلاجي بمجرد أعمل touch لل sperm بنهاية ال
+
+265
+00:19:18,450 --> 00:19:22,890
+injection needle هيصير عملية rolling في نهاية ال
+
+266
+00:19:22,890 --> 00:19:27,110
+tail ال tail هيعمل rolling يعني التفاف ولو بسيط
+
+267
+00:19:27,110 --> 00:19:32,530
+جدا بخلاف ال sperm الميت هيكون عبارة عن street
+
+268
+00:19:32,530 --> 00:19:38,410
+line مش هيؤدي ولا رد فعل تذكركيف ممكن أن اتأكد
+
+269
+00:19:38,410 --> 00:19:41,770
+بفحص كتير حكينا فيه في مصابق اسمه الـ Hypo
+
+270
+00:19:41,770 --> 00:19:47,070
+Cosmetic Swelling Solution ان انا باخد هذا ال
+
+271
+00:19:47,070 --> 00:19:51,630
+sperm و بضيفه فيه Cosmetic Solution اذا والله
+
+272
+00:19:51,630 --> 00:19:56,150
+انتفخ التل معناه هذا ال sperm حي ماانتفخش هذا ال
+
+273
+00:19:56,150 --> 00:20:00,050
+sperm غير حي عشان كده بقول الجميط و ال functional
+
+274
+00:20:00,050 --> 00:20:04,310
+membranewill undergo swelling of the cytoplasmic
+
+275
+00:20:04,310 --> 00:20:08,510
+space and sperm till fiber will be colloid هذا
+
+276
+00:20:08,510 --> 00:20:13,430
+معناه بأن الـ sperm هي الـ sperm استجاب لاختلاف
+
+277
+00:20:13,430 --> 00:20:17,110
+الضغط الأسموذي إذا هذا ال sperm ممكن أخته أعمله
+
+278
+00:20:17,110 --> 00:20:21,910
+immobilization و أستخدمه في عملية الحقن هذه الصورة
+
+279
+00:20:21,910 --> 00:20:26,330
+بتتكلم عن الحوار اللي أنا حكيته قبل شوية هذا الـ
+
+280
+00:20:26,330 --> 00:20:31,010
+osmotic ribo osmotic swelling testكيف الـ sperm
+
+281
+00:20:31,010 --> 00:20:36,230
+ماتزوب تستجيب لاختلاف الضغط الأسموزي إذا كان ال
+
+282
+00:20:36,230 --> 00:20:40,390
+sperm live زي هذا الشكل و هذا الشكل و هذا الشكل و
+
+283
+00:20:40,390 --> 00:20:43,630
+هذا الشكل هدولة صار فيها عندك swelling أو صار فيها
+
+284
+00:20:43,630 --> 00:20:47,830
+عندك coil في نهاية ال sperm معناه هذا live الصورة
+
+285
+00:20:47,830 --> 00:20:51,970
+هذه رقم A اللي بدي أحكي عليها بتبينلي عملية الحركة
+
+286
+00:20:51,970 --> 00:20:56,290
+أنا هاي عند ال sperm هاي ال sperm بالشكل هذا أجيت
+
+287
+00:20:56,290 --> 00:21:00,620
+بنهاية ال needle أو ال injection needleو وضعتها في
+
+288
+00:21:00,620 --> 00:21:04,680
+نهاية ال sperm و بدأت اتحرك في اتجاه السهم لما
+
+289
+00:21:04,680 --> 00:21:09,100
+بدأت اتحرك في اتجاه السهم في نوع من انواع الليونة
+
+290
+00:21:09,100 --> 00:21:17,020
+في حركة ال sperm اضف إلى ذلك ان ال head اتحرك مع
+
+291
+00:21:17,020 --> 00:21:21,600
+حركة ال tail بحركة متناغمة اضف إلى ذلك ان ال tail
+
+292
+00:21:21,600 --> 00:21:27,580
+اخد التفاف بسيط على طرف ال injection needle معناه
+
+293
+00:21:27,580 --> 00:21:33,450
+في استجابةمن قبل الـ tail ال head و ال tail تحركت
+
+294
+00:21:33,450 --> 00:21:40,910
+كحركة و كتلة واحدة نجلة P بيها دي إذا كانت م tile
+
+295
+00:21:40,910 --> 00:21:46,010
+و non-life أنا أجيت وضعت ال injection needle في
+
+296
+00:21:46,010 --> 00:21:50,670
+نهاية ال tail و اتحركت لأعلى على سبيل المثال بلاجي
+
+297
+00:21:50,670 --> 00:21:55,050
+كل أنا راح أتحرك لأعلى ال head بنزل لأسفل كأنه
+
+298
+00:21:55,050 --> 00:22:01,950
+مافيش حركةواضحة خاصة فيهم مافيش حركة واضحة خاصة
+
+299
+00:22:01,950 --> 00:22:07,830
+فيهم مافيش استجابة من قبل ال tail مافي الليونة
+
+300
+00:22:07,830 --> 00:22:12,170
+التي ظهرت مافي الإنحناء اللذي ظهر في نهاية ال tail
+
+301
+00:22:12,170 --> 00:22:15,550
+زي الصورة الأولى طبعا هذه بيستخدموها بس لازم تكون
+
+302
+00:22:15,550 --> 00:22:18,910
+professional فيها شوية اتعلمت مرة و مرتين و تلاتة
+
+303
+00:22:18,910 --> 00:22:24,450
+هذه أكثر استخدام تاعة ال hypocosmotic طبعا في شغل
+
+304
+00:22:24,450 --> 00:22:30,600
+تانيةإنه في حركة A بمجرد أنا مارفع ال needle عن
+
+305
+00:22:30,600 --> 00:22:33,700
+نهاية ال tail ال tail برجع لوضعه الطبيعي برجع
+
+306
+00:22:33,700 --> 00:22:37,840
+لوضعه الطبيعي بينما هنا لأ بضله كما هو fixed مافي
+
+307
+00:22:37,840 --> 00:22:44,840
+أي ردد فعل فهذا معناه non-life وهذا معناه life في
+
+308
+00:22:44,840 --> 00:22:49,200
+طريقة تانية بستخدموها بستخدموا فيها ال laser وهو
+
+309
+00:22:49,200 --> 00:22:55,820
+ببساطة جدا بيجي بعمل إطلاق لقذيفة من ال laserبحجب
+
+310
+00:22:55,820 --> 00:23:00,680
+معين و بكمية معينة و بقوة معينة على نهاية ال tail
+
+311
+00:23:00,680 --> 00:23:05,340
+و ال sperm في داخلها إذا والله ال sperm non motile
+
+312
+00:23:05,340 --> 00:23:11,240
+ولكن life مباشرة هلاجي ال tail استجاب للطلقة و عمل
+
+313
+00:23:11,240 --> 00:23:16,760
+التفاف في النهاية معناه والله إن هذا ال sperm life
+
+314
+00:23:16,760 --> 00:23:22,300
+عشان كده استجاب لهذا الطلقة إذا كان ال sperm بعد
+
+315
+00:23:22,300 --> 00:23:26,320
+الطلقة شعار laser لم يستجيبفهذا معناه إن الـ sperm
+
+316
+00:23:26,320 --> 00:23:31,080
+dead، non-motile، non-life، لا يمكن أن يُستخدم في
+
+317
+00:23:31,080 --> 00:23:35,220
+الحقن الميجاري طبعاً هذه طريقة و هذه طريقة طبعاً
+
+318
+00:23:35,220 --> 00:23:39,200
+كل الطرق حالياً بتميل إلى استخدام الـ laser بيقولك
+
+319
+00:23:39,200 --> 00:23:45,240
+أسرع و أضمن ولكن هذا يعتمد على كمية الحالات اللي
+
+320
+00:23:45,240 --> 00:23:47,740
+بتيجي على المركز والله المركز بيجيله في الشهر 50
+
+321
+00:23:47,740 --> 00:23:52,260
+حالة هيجيب هذا الطريقة أسرعله و أضمنله بشكل كبير
+
+322
+00:23:52,260 --> 00:23:59,250
+جداًطبعاً هذا الشكل بيظهر لي مكونات عملية الحقن
+
+323
+00:23:59,250 --> 00:24:03,530
+المجهري أنا قلت على اليمين مباشرة عند الساعة تلاتة
+
+324
+00:24:03,530 --> 00:24:06,810
+في حاجة بنتسميها الـ Injection Needle هذه دائما
+
+325
+00:24:06,810 --> 00:24:10,450
+بتحمل الـ spermatozoa بداخلها عشان كده داخلها لازم
+
+326
+00:24:10,450 --> 00:24:14,250
+يكون مغسول بالـ PVP media على اليسار في اتجاه
+
+327
+00:24:14,250 --> 00:24:17,810
+الساعة تسعة في حاجة اسمها Holding Tube وهي اللي
+
+328
+00:24:17,810 --> 00:24:22,740
+بتعمل Fixing أو Fixation للـ Oocyteما بتخلّي الـ
+
+329
+00:24:22,740 --> 00:24:28,340
+Oocyte تتحرك دايما الـ Oocyte عند الحقن بأعملها
+
+330
+00:24:28,340 --> 00:24:31,940
+suction باستخدام ال holding pipet و لازم يكون ال
+
+331
+00:24:31,940 --> 00:24:36,320
+polar body في اتجاه الساعة 12 أو في اتجاه الساعة 6
+
+332
+00:24:36,320 --> 00:24:42,640
+و أبدأ عملية ال injection بشكل موازي لل holding
+
+333
+00:24:42,640 --> 00:24:45,980
+pipet لو أنا مافيش عندي pipet مافيش عندي عقون
+
+334
+00:24:45,980 --> 00:24:49,480
+Oocyte في هذا المكان و مافيش عندي spermatozoa وبدا
+
+335
+00:24:49,480 --> 00:24:53,590
+أتأكد هل ال injection needleموضوع بشكل صحيح هي و
+
+336
+00:24:53,590 --> 00:24:56,810
+ال holding pipet بقربهم بعض إذا دخلت ال injection
+
+337
+00:24:56,810 --> 00:25:01,730
+needle في الفجوة هذه الموجودة في مقدمة ال holding
+
+338
+00:25:01,730 --> 00:25:05,610
+pipet يعني تركيب ال two tools صحيح مية في المية
+
+339
+00:25:05,610 --> 00:25:11,510
+مافي عند مشكلة فببدأ أقدر أبدأ شغلي هذه فكرة عملية
+
+340
+00:25:11,510 --> 00:25:15,950
+ال injection و كيف تتم عملية ال injection مباشرة
+
+341
+00:25:15,950 --> 00:25:19,630
+تحت ال injection microscope أو ال X microscope
+
+342
+00:25:20,470 --> 00:25:25,490
+بأتأكد إن الـ egg موجودة على عدسة 200x بعدين بغير
+
+343
+00:25:25,490 --> 00:25:29,170
+ال field على عدسة 40x عشان يكون ال field أكثر وضوح
+
+344
+00:25:29,170 --> 00:25:35,750
+بعمل holding لبوايضة باستخدام ال holding by bit و
+
+345
+00:25:35,750 --> 00:25:41,450
+بخلّي ال polar body يا إما 66 أو 12 و باخد ال
+
+346
+00:25:41,450 --> 00:25:44,450
+injection needle اللي فيها ال sperm طبعا إذا كنت
+
+347
+00:25:44,450 --> 00:25:48,380
+متمرس في الحكاية هذهممكن تدخل داخل ال injection
+
+348
+00:25:48,380 --> 00:25:51,460
+needle تلاتة sperm عشان تحقن تلات بوايدات ولكن
+
+349
+00:25:51,460 --> 00:25:56,720
+الأفضل كل مرة لك تحقن بوايدة لازم يكون only single
+
+350
+00:25:56,720 --> 00:26:00,400
+sperm موجود داخل ال injection needle بعدين تيجي
+
+351
+00:26:00,400 --> 00:26:06,160
+تبدأ تحقن البوايدة بكل بدوء تتأكد إنك إنت اخترقت
+
+352
+00:26:06,160 --> 00:26:09,880
+الزونابليوسيدا أول ما تخترق الزونابليوسيدا و تحس
+
+353
+00:26:09,880 --> 00:26:12,800
+إنك دخلت ال cytoplasm طبعا لما تخترب من
+
+354
+00:26:12,800 --> 00:26:15,300
+الزونابليوسيدا و الcelmanpirale هتلاقي فيه مقاومة
+
+355
+00:26:15,990 --> 00:26:19,950
+أول ما تختارقها كإنك زي بلون و تم انفجاره، بالضبط
+
+356
+00:26:19,950 --> 00:26:23,690
+كذا تتأكد إنك موجود في الـ cytoplasm هتعمل suction
+
+357
+00:26:23,690 --> 00:26:28,570
+أو aspiration لكمية قليلة جدا من الـ sperm من الـ
+
+358
+00:26:28,570 --> 00:26:32,110
+cytoplasm الخاص بالـ oocyte بعد كده تعمل releasing
+
+359
+00:26:32,110 --> 00:26:36,670
+لهذه الكمية اللي سحبتها plus ال spermatozoo اللي
+
+360
+00:26:36,670 --> 00:26:42,490
+موجودة داخل ال injection needle طب شو هي .. لإيش
+
+361
+00:26:42,490 --> 00:26:45,850
+أنا بعملأسبيريشن للـ cytoplasm و لو كانت كمية قليل
+
+362
+00:26:45,850 --> 00:26:49,490
+جدا ليه شغل تاني؟ شغل الأولى إنه يتأكد إنه داخل
+
+363
+00:26:49,490 --> 00:26:53,890
+الـ oocyte شغل التانى عملية الـ aspiration لكمية
+
+364
+00:26:53,890 --> 00:26:56,650
+قليل جدا من الـcytoplasm تعمل زي دوامات بسيطة داخل
+
+365
+00:26:56,650 --> 00:27:01,710
+الخلية تنبيه خلية صار فيها اندفرتاليزيشن صار فيه
+
+366
+00:27:01,710 --> 00:27:04,410
+اختراق للزورة بلوسيدا يعني في عملية fertilization
+
+367
+00:27:04,410 --> 00:27:10,250
+قادمة تبدأ في استقبال الـ spermatozoa زي عملية
+
+368
+00:27:10,250 --> 00:27:17,300
+بنسميها activationهذه شكل الميكروسكوب الخاص بيه
+
+369
+00:27:17,300 --> 00:27:21,380
+طبعا هذه المناطق اللي احنا بنتكلم عنها طبعا هنا
+
+370
+00:27:21,380 --> 00:27:24,980
+بتكون ال injection needle هنا بتكون ال holder هذه
+
+371
+00:27:24,980 --> 00:27:29,620
+كلها المناطق و الأدوات اللي علاقة بال holder تحريك
+
+372
+00:27:29,620 --> 00:27:34,620
+لليمين اليسار للخلف للأمام للأعلى للأسفل الدغط
+
+373
+00:27:34,620 --> 00:27:37,220
+الداخل ال holder عملية ال suction عملية ال
+
+374
+00:27:37,220 --> 00:27:41,130
+releasing وهذه الموادو هذه الأدوات خاصة بالـ
+
+375
+00:27:41,130 --> 00:27:44,510
+injection needle تقديمها للأمام من الخلف عملية ال
+
+376
+00:27:44,510 --> 00:27:47,130
+releasing عملية ال suction عملية ال aspiration
+
+377
+00:27:47,130 --> 00:27:51,550
+تحريكها بشكل دائري أيضا يعني إلى حد ما إذا مافيش
+
+378
+00:27:51,550 --> 00:27:55,610
+stress just give بتصير القصة ولكن ال stress هو
+
+379
+00:27:55,610 --> 00:27:59,930
+اللي بيخلي فيها صعوبة إلى حد ما مهم جدا بعد عملية
+
+380
+00:27:59,930 --> 00:28:03,550
+releasing لل spermatozoon داخل ال oocyte أني أخرج
+
+381
+00:28:03,550 --> 00:28:08,610
+بكل سلاسة و بكل هدوء ما أعمل تهتك لل oocyte هذه
+
+382
+00:28:08,610 --> 00:28:12,220
+العمليةلو انت مبتدأ هتاخد لك دقيقة أو نصف دقيقة لو
+
+383
+00:28:12,220 --> 00:28:15,620
+انت بتشتغل في هذا المجال بشكل كبير جدا هتاخد فقط
+
+384
+00:28:15,620 --> 00:28:23,540
+تلاتين ثانية تلاتين ثانية القمر كله هياخد دقيقة
+
+385
+00:28:23,540 --> 00:28:23,560
+دقيقة دقيقة دقيقة دقيقة دقيقة دقيقة دقيقة دقيقة
+
+386
+00:28:23,560 --> 00:28:23,560
+دقيقة دقيقة دقيقة دقيقة دقيقة دقيقة دقيقة دقيقة
+
+387
+00:28:23,560 --> 00:28:26,720
+دقيقة دقيقة دقيقة دقيقة دقيقة ديكتر ديكتر ديكتر
+
+388
+00:28:26,720 --> 00:28:26,800
+ديكتر ديكتر ديكتر ديكتر ديكتر ديكتر ديكتر ديكتر
+
+389
+00:28:26,800 --> 00:28:38,720
+ديكتر ديكتر ديكتر ديكتر ديكتر ديكت
+
+390
+00:28:38,900 --> 00:28:47,200
+400 هذا
+
+391
+00:28:47,200 --> 00:28:52,760
+الـ polar body الموجود عند العدسة عند الساعة 6 هذا
+
+392
+00:28:52,760 --> 00:28:56,800
+polar body هذا هو ال polar body المفروض أبعد عنه
+
+393
+00:28:56,800 --> 00:29:01,860
+أدخل طالما مقابل الفجوة هذه يعني أدخل من عند
+
+394
+00:29:01,860 --> 00:29:06,150
+الساعة 3 عشان أتأكد إن دخلت بالشكل الصحيحخُدوا
+
+395
+00:29:06,150 --> 00:29:08,770
+بالكوا هنا في partial denotation لأنه لو عمل الـ
+
+396
+00:29:08,770 --> 00:29:11,170
+denotation بشكل صحيح كل هذه ال accumulations
+
+397
+00:29:11,170 --> 00:29:14,250
+المفروض تروح تكون هاريا الخلية إلى حد ما
+
+398
+00:29:36,970 --> 00:29:40,630
+شايفين هذا الـ spermatozoa؟ قبل ما يدخل الخلية و
+
+399
+00:29:40,630 --> 00:29:43,490
+يعمل penetration للـ zoonablucida لازم ينسي ال
+
+400
+00:29:43,490 --> 00:29:46,970
+spermatozoa هذه البلون الفضي إلى أقرب منطقة من
+
+401
+00:29:46,970 --> 00:29:50,430
+فوية ال injection عشان ما ينزلش كتير PVP ميديا
+
+402
+00:29:50,430 --> 00:29:55,610
+داخل أوهوسايت كمان
+
+403
+00:29:55,610 --> 00:30:00,470
+هيصل لمنطقة هذه المفروض يصل لمنطقة هذه لحد ما
+
+404
+00:30:00,470 --> 00:30:06,600
+تمام؟ المفروض هلوجد يبدأ يخترق البويضة بكل هدوءبدا
+
+405
+00:30:06,600 --> 00:30:12,320
+يشعر فيه مقاومة بدا ياخد حرف ال U دليل انه موجود
+
+406
+00:30:12,320 --> 00:30:16,920
+على سطح ال spermatozoa سطح ال cytoplasm ال
+
+407
+00:30:16,920 --> 00:30:23,280
+cytoplasm بالمرن بدا يخترق .. يخترق .. هيصير
+
+408
+00:30:23,280 --> 00:30:28,100
+انفجار كده صار انفجار المفروض ياخد aspiration جزء
+
+409
+00:30:28,100 --> 00:30:32,980
+بسيط هياخد aspiration هيرتفع ال spermatozoa داخل
+
+410
+00:30:32,980 --> 00:30:33,640
+injection needle
+
+411
+00:30:36,400 --> 00:30:41,300
+بعدين يعمل releasing لـ spermatozoon علشان تبدأ
+
+412
+00:30:41,300 --> 00:30:46,140
+عملية ال fertilization شايفين؟ أعمل aspiration
+
+413
+00:30:46,140 --> 00:30:51,700
+ارتفع الـ cytoplasm ومعه ارتفع ال sperm بعد كده
+
+414
+00:30:51,700 --> 00:30:56,120
+هيعمل releasing علشان يتم عملية ال fertilization
+
+415
+00:31:08,630 --> 00:31:13,250
+كدا خلص عملية هاي الـ sperm الموجودة هذه كدا خلص
+
+416
+00:31:13,250 --> 00:31:17,430
+عملية ال fertilization بالشكل الكامل والشكل
+
+417
+00:31:17,430 --> 00:31:22,250
+المطلوب طبعا هذه الصورة بتوضح الخطوات نبدأ من A
+
+418
+00:31:22,250 --> 00:31:26,130
+الموجودة على اليسار holder injection needle
+
+419
+00:31:26,130 --> 00:31:33,270
+spermatozoa Oocyte في عندي polar body دخل لامس الـ
+
+420
+00:31:33,270 --> 00:31:37,710
+zona pellucidaبدا يضغط فيها بشواش تكوّن حرف الـ V
+
+421
+00:31:37,710 --> 00:31:44,270
+أو الـ U اخترق هاي الـ spermatozoa هيدخل إلى أقصى
+
+422
+00:31:44,270 --> 00:31:49,410
+مكان ممكن هيعمل aspiration بعدين يعمل releasing
+
+423
+00:31:49,410 --> 00:31:54,470
+بعد ما يعمل releasing هيسحب و يبدأ يخرج من نفس
+
+424
+00:31:54,470 --> 00:31:59,270
+المكان اللي دخل منه هيتأكد انه كده عمل عملية الحقد
+
+425
+00:31:59,270 --> 00:32:03,970
+بالشكل السليم والشكل المطلوبهنكتفي بهذا القدر في
+
+426
+00:32:03,970 --> 00:32:08,690
+هذه المحاضرة على أمل أن نكمل ما تبقى من محاضرة ال
+
+427
+00:32:08,690 --> 00:32:14,210
+Exe وعملية التلقيح و الحقنص مجهري في المحاضرات
+
+428
+00:32:14,210 --> 00:32:14,750
+القادمة
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/kSV23vKKJRo_postprocess.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/kSV23vKKJRo_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..576201eb162544dbd1a2a1a93f79e0a39c66f1b6
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/kSV23vKKJRo_postprocess.srt
@@ -0,0 +1,2388 @@
+1
+00:00:00,840 --> 00:00:04,860
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:04,860 --> 00:00:10,460
+المرسلين سيدنا محمد وعلى آله وصحبه أجمعين طلابنا
+
+3
+00:00:10,460 --> 00:00:14,600
+الأعزاء نرجو من الله الكريم أن تكونوا جميعا بخير
+
+4
+00:00:14,600 --> 00:00:19,980
+وبصحة جيدة استكمالا لما بدأنا فيه من مواضيع متعلقة
+
+5
+00:00:19,980 --> 00:00:25,240
+بالحقن المجهري أساليبه وأنواعهوطرقه تحدثنا في
+
+6
+00:00:25,240 --> 00:00:28,340
+المحاضرات السابقة عن ال spermogenesis و ال
+
+7
+00:00:28,340 --> 00:00:32,600
+oogenesis تحدثنا عن الخطوات التي تمور بها ال
+
+8
+00:00:32,600 --> 00:00:36,720
+spermocyte من لحظة التصنيع حتى لحظة ال ejaculation
+
+9
+00:00:36,720 --> 00:00:40,980
+ثم مرورا بال reproductive system الخاص بالفيميل
+
+10
+00:00:40,980 --> 00:00:44,980
+لحظة ال intercourse من أجل ال fertilization ثم
+
+11
+00:00:44,980 --> 00:00:48,800
+تحدثنا عن ال oogenesis and الفيميل و كيف يحدث
+
+12
+00:00:48,800 --> 00:00:53,360
+عملية reduction في ال oocyte countتحت مصطلح
+
+13
+00:00:53,360 --> 00:00:59,920
+atresia وصولا إلى سن الرشد ثم مرورا بمراحل الدورة
+
+14
+00:00:59,920 --> 00:01:04,140
+الشهرية menstrual cycle التي تحدث عند السيدة وكام
+
+15
+00:01:04,140 --> 00:01:09,020
+بوايضة يتنفقدانها تحت مصطلح atresia بشكل شهري ماهي
+
+16
+00:01:09,020 --> 00:01:13,720
+الهرمونات التي تساهم في إنتاج وانداج البوايضة؟ متى
+
+17
+00:01:13,720 --> 00:01:17,280
+يحدث التلقيح؟ وأين يحدث التلقيح؟ ماهو الكوربس
+
+18
+00:01:17,280 --> 00:01:21,690
+اليوتيام؟ ماهو الكوربس البيكان؟متى يتكون ومتى
+
+19
+00:01:21,690 --> 00:01:27,290
+يندثر أو يتكسّر اليوم سننتقل إلى مربع جديد له
+
+20
+00:01:27,290 --> 00:01:31,990
+علاقة بالميل بشكل أساسي تحت مصطلح sperm assessment
+
+21
+00:01:31,990 --> 00:01:37,170
+processing and selection وذلك لأن عملية ال
+
+22
+00:01:37,170 --> 00:01:41,010
+fertilization أو عملية الإجزي الـ Intracytoplasmic
+
+23
+00:01:41,010 --> 00:01:44,810
+sperm injection تحتاج إلى single sperm لكي تتم
+
+24
+00:01:44,810 --> 00:01:50,790
+بشكل أبيعي وبشكل سليمإضافة إلى single oocyte يجب
+
+25
+00:01:50,790 --> 00:01:56,130
+أن تكون mature فبالتالي الإجزة عملية تحتاج إلى two
+
+26
+00:01:56,130 --> 00:02:00,050
+جميط Male جميط هي single sperm mature و Female
+
+27
+00:02:00,050 --> 00:02:04,390
+جميط هي oocyte mature ولكي تحدث عملية ال
+
+28
+00:02:04,390 --> 00:02:07,850
+fertilization يجب أن يحدث عملية treatment أو
+
+29
+00:02:07,850 --> 00:02:12,110
+processing للسمين ال fluid أو للسمين ال sample أو
+
+30
+00:02:12,110 --> 00:02:16,070
+للسمين ال sample علشان أقدر أن أحصل على only one
+
+31
+00:02:16,070 --> 00:02:16,910
+single sperm
+
+32
+00:02:21,890 --> 00:02:26,780
+العملية تحتاج إلى عمليةEvaluation للـ Seminal
+
+33
+00:02:26,780 --> 00:02:30,620
+Fluid تحتاج إلى عملية assessment للـ Seminal Fluid
+
+34
+00:02:30,620 --> 00:02:35,380
+تحتاج إنك تكتب تقرير صحيح وسليم المشكلة إن معظم ال
+
+35
+00:02:35,380 --> 00:02:38,040
+routine lab ما بتقوم بعمل ال Seminal Fluid
+
+36
+00:02:38,040 --> 00:02:41,700
+Analysis أو الـ Semin Analysis باستثناء المرايات
+
+37
+00:02:41,700 --> 00:02:45,480
+والمختبرات المتخصصة التي لها علاقة بال Andrology
+
+38
+00:02:45,480 --> 00:02:50,100
+أو التي لها علاقة باطفال الحقن المجاني معظم الطلاب
+
+39
+00:02:50,100 --> 00:02:56,090
+يكون عندهم افتقار فيهذا الشق بسبب عدم التمرس و عدم
+
+40
+00:02:56,090 --> 00:03:00,630
+التدريب و التدرب عليه لذلك يجب علينا أن نفرض جزء
+
+41
+00:03:00,630 --> 00:03:05,890
+من هذه المحاضرات تتعلق بـ Seminal Process أو
+
+42
+00:03:05,890 --> 00:03:10,130
+Seminal Analysis لما أقول أنا عندي infertility
+
+43
+00:03:10,130 --> 00:03:14,190
+Male infertile يعني غير قادر أو عنده مشكلة خليني
+
+44
+00:03:14,190 --> 00:03:18,490
+أسميها في الحصول على طفللما أقول عندي مال استرال
+
+45
+00:03:18,490 --> 00:03:22,850
+يعني ذكر عقيم لا يستطيع أن ينجب سواء كان بالطريقة
+
+46
+00:03:22,850 --> 00:03:27,710
+الطبيعية أو بالطريقة الصناعية من خلال الحقن
+
+47
+00:03:27,710 --> 00:03:34,930
+المجاني ومع ذلك صنف ال WHO بعض الذكور على أنه
+
+48
+00:03:34,930 --> 00:03:40,540
+Proven Fertilefertile, subfertile, sterile طبعا
+
+49
+00:03:40,540 --> 00:03:44,980
+هذا يعتمد على المقدر على الإنجاب بشكل طبيعي المقدر
+
+50
+00:03:44,980 --> 00:03:48,320
+على الإنجاب بعد التلقيح الصناعي وكيف تكون ال semen
+
+51
+00:03:48,320 --> 00:03:53,660
+parameter فبالتالي وجدوا أن ال seminal analysis أو
+
+52
+00:03:53,660 --> 00:03:59,600
+تحليل السائل عند الذكور هو عبارة عن أول فحص يطلب
+
+53
+00:03:59,600 --> 00:04:04,930
+من أجل تشخيص القدرة الإنجابية عند الرجلWe can
+
+54
+00:04:04,930 --> 00:04:08,330
+evaluate the fertility status for any male person
+
+55
+00:04:08,330 --> 00:04:12,890
+by using seminal analysis as a fair system بناء
+
+56
+00:04:12,890 --> 00:04:15,930
+على ال seminal analysis ممكن أن أحصل على بعض ال
+
+57
+00:04:15,930 --> 00:04:20,490
+information التي تتعلق بالـ functional of sperm
+
+58
+00:04:20,490 --> 00:04:23,730
+production by testis هل ال testis بتفرزلي و
+
+59
+00:04:23,730 --> 00:04:29,390
+بتنتجلي sperm بشكل كافي وبالكمية المطلوبة وبالحجم
+
+60
+00:04:29,390 --> 00:04:34,450
+المطلوب وبالعدد المطلوبأضف إلى ذلك الـ potency of
+
+61
+00:04:34,450 --> 00:04:39,690
+genital tract كيف هي قدرة الـ genital tract في نقل
+
+62
+00:04:39,690 --> 00:04:43,090
+و في إخراج الـ seminal fluid هل تمشي و تسير بشكل
+
+63
+00:04:43,090 --> 00:04:47,790
+طبيعي أم هناك بعض المشاكل؟ أيضًا بيعطيني picture و
+
+64
+00:04:47,790 --> 00:04:52,410
+photo كاملة عن الـ secretory activity of the all
+
+65
+00:04:52,410 --> 00:04:54,370
+accessory gland الـ accessory gland زي الـ
+
+66
+00:04:54,370 --> 00:04:58,110
+prostatic gland كيف طبيعة عمل؟ هل تعمل بشكل سليم؟
+
+67
+00:04:58,280 --> 00:05:01,420
+تعمل بشكل دقيق، في عندها مشكلة، في عندى
+
+68
+00:05:01,420 --> 00:05:03,660
+deficiencies في الـ activity الخاصة فيها أمهية
+
+69
+00:05:03,660 --> 00:05:06,580
+normal في الـ normal status The information
+
+70
+00:05:06,580 --> 00:05:11,720
+contributes to the effective establishment of
+
+71
+00:05:11,720 --> 00:05:15,200
+individual diagnoses and serve as the essential
+
+72
+00:05:15,200 --> 00:05:18,460
+basic investigation of male factors on the
+
+73
+00:05:18,460 --> 00:05:22,240
+infertile couple فبالتاني، الـ seminal fluid يعتبر
+
+74
+00:05:22,240 --> 00:05:26,180
+أول فحص يطلب في تشخيص الحالة الإنجابية أو القدرة
+
+75
+00:05:26,180 --> 00:05:30,950
+الإنجابية عند اللأنه هيعطيني صورة عامة إلى حد ما
+
+76
+00:05:30,950 --> 00:05:37,230
+عن الوضع الحالي الذي يتمتع بيه الذاكرة بالنسبة لل
+
+77
+00:05:37,230 --> 00:05:40,810
+Basic Seminal Analysis بيلعب دور مهم جدا في الـ
+
+78
+00:05:40,810 --> 00:05:43,350
+Central .. الـ Central role في ال diagnostic of
+
+79
+00:05:43,350 --> 00:05:46,990
+male infertility في ال making significant
+
+80
+00:05:46,990 --> 00:05:49,750
+contribution to the diagnosis process in
+
+81
+00:05:49,750 --> 00:05:54,390
+andrology، gynecologyunclinical urology في تلاتة
+
+82
+00:05:54,390 --> 00:05:57,970
+unit هذه ال unit الخاص بالclinical urology ال unit
+
+83
+00:05:57,970 --> 00:06:00,150
+الخاص بالandrology ال unit الخاص بالclinical ال
+
+84
+00:06:00,150 --> 00:06:04,810
+clinic أو ال unit الخاص بكينيكولوجيا تولدت تلاتة
+
+85
+00:06:04,810 --> 00:06:08,710
+unit بيهتموا بال seminal analysis بالدرجة الأولى
+
+86
+00:06:08,710 --> 00:06:14,470
+as basic analysis or basic test في طبعا اختلاف ما
+
+87
+00:06:14,470 --> 00:06:17,650
+بين العلماء فعلى سبيل المثال في الأيام الحالية
+
+88
+00:06:17,650 --> 00:06:21,680
+الدراسات حكت أنهExamination include the analysis
+
+89
+00:06:21,680 --> 00:06:26,000
+of certain established seminal parameters can
+
+90
+00:06:26,000 --> 00:06:29,020
+provide key information about the quality of
+
+91
+00:06:29,020 --> 00:06:33,880
+patient's semen and functional of sperm بمعنى آخر
+
+92
+00:06:33,880 --> 00:06:37,620
+إن أنا بمجرد ما أحصل على تقرير له علاقة بالـ
+
+93
+00:06:37,620 --> 00:06:41,760
+Seminal Analysis بشكل صحيح ومضبوط أستطيع أن أحصل
+
+94
+00:06:41,760 --> 00:06:45,800
+على صورة مبدئية عن الوضع الصحي والإنجابي الخاص
+
+95
+00:06:45,800 --> 00:06:49,910
+بالمرض وبما على ليه بقدر أشخص الحالة المرضيةوبقدر
+
+96
+00:06:49,910 --> 00:06:53,610
+أحدد في ببعض طبيعة الفحوصات اللي أنا ممكن أطلبها
+
+97
+00:06:53,610 --> 00:06:57,990
+في المستقبل علشان يعملي correct or true diagnostic
+
+98
+00:06:57,990 --> 00:07:04,310
+or حاجة بنسميها تشخيص سليم، تشخيص صحيح 100% this
+
+99
+00:07:04,310 --> 00:07:06,850
+information can help to determine reproductive
+
+100
+00:07:06,850 --> 00:07:11,630
+capacity of male فبالتالي ممكن أنا من فقط ال
+
+101
+00:07:11,630 --> 00:07:14,910
+seminal fluid أو ال seminal analysis أتعرف على
+
+102
+00:07:14,910 --> 00:07:19,110
+الحالة الإنجابيةالـ WHO وهي اختصار للـ World
+
+103
+00:07:19,110 --> 00:07:23,650
+Healthy Organization عملت دراسات وعملت reference
+
+104
+00:07:23,650 --> 00:07:28,090
+value للـ seminal fluid بمعنى قيم متعلقة بالـ
+
+105
+00:07:28,090 --> 00:07:32,010
+Fertile Men أو Fertile Males ما هي الـ reference؟
+
+106
+00:07:32,010 --> 00:07:34,530
+يعني كم يجب أن تكون الـ utility كم يجب أن تكون
+
+107
+00:07:34,530 --> 00:07:36,790
+الحركة؟ كم يجب أن تكون العدد؟ كم يجب أن تكون ال
+
+108
+00:07:36,790 --> 00:07:39,430
+morphology؟ كم يجب أن تكون ال volume؟ كم يجب أن
+
+109
+00:07:39,430 --> 00:07:44,580
+تكون ال pH؟ هذا نسميها reference value أيضاووجدوا
+
+110
+00:07:44,580 --> 00:07:49,300
+وصنعوا وكوّنوا وحضروا multi-step for manual
+
+111
+00:07:49,300 --> 00:07:54,280
+seminal analysis كنت ك تكنيشن ك أندرولوجيست كيف
+
+112
+00:07:54,280 --> 00:07:57,580
+تستطيع عمل تحليل السائل ما هي الخطوات المتبعة من
+
+113
+00:07:57,580 --> 00:08:03,560
+لحظة استلام العينة حتى كتابة التقرير لكي نجمل هذه
+
+114
+00:08:03,560 --> 00:08:08,760
+النقاط و هذه الخطوات قسموها إلى pre-analytical وهي
+
+115
+00:08:08,760 --> 00:08:13,110
+خطواتنا قبل الفحصanalytical خطوات متعلقة بالفحص
+
+116
+00:08:13,110 --> 00:08:18,130
+post-analytical خطوات ما بعد الفحص وهي التي تشمل
+
+117
+00:08:18,130 --> 00:08:22,690
+في كتابة التقرير وتفسير النتائج فبالتالي الـ
+
+118
+00:08:22,690 --> 00:08:25,690
+Seminal بالوضع الطبيعي هو عبارة عن heterogeneous
+
+119
+00:08:25,690 --> 00:08:31,530
+fluid بتكون من عدة مكونات مختلفة هذه المكونات قد
+
+120
+00:08:31,530 --> 00:08:36,650
+تتأثر بعوامل داخلية لها علاقة بالبيئة الداخلية
+
+121
+00:08:36,650 --> 00:08:41,870
+لجسد الإنسان أو جسد الذكروطبيعة غذائه وعوامل
+
+122
+00:08:41,870 --> 00:08:44,450
+خارجية اللي بتسميها environment factor أو
+
+123
+00:08:44,450 --> 00:08:48,870
+extrinsic factor من أشهر العوامل اللتي قد تؤثر على
+
+124
+00:08:48,870 --> 00:08:52,650
+ال infertility أو على خلّيني أسميها بشكل أوضح على
+
+125
+00:08:52,650 --> 00:08:57,150
+ال seminal analysis ال infection هل وجود infection
+
+126
+00:08:57,150 --> 00:09:02,130
+في القنوات الناقلة أو في المصنع ال accessory gland
+
+127
+00:09:02,130 --> 00:09:06,770
+function كيف وظيفة هذه الغدد المساعد هل تقوم
+
+128
+00:09:06,770 --> 00:09:11,330
+بالوظيفة المطلوبة ولا فيها انها inhibitionالـ
+
+129
+00:09:11,330 --> 00:09:14,870
+period of sexual absence الفترة الإمتناء عن الـ
+
+130
+00:09:14,870 --> 00:09:17,570
+ejaculation تلت أيام ولا أربع أيام ولا خمس أيام
+
+131
+00:09:17,570 --> 00:09:21,450
+خدوا بالك الفترة هذه مهمة جدا لأنه بناء عليها أنا
+
+132
+00:09:21,450 --> 00:09:26,410
+بقدر أقيم بشكل سليم وبشكل صحيح ال value اللي بتطلع
+
+133
+00:09:26,410 --> 00:09:31,090
+بعد تحليل السائل أيضا من العوامل التي تؤثر
+
+134
+00:09:31,090 --> 00:09:35,570
+anatomical hormonalGenetic Life Style Factors All
+
+135
+00:09:35,570 --> 00:09:39,450
+of these factors can contribute to male fertility
+
+136
+00:09:39,450 --> 00:09:42,490
+خدوا بالك الهرمون عامل مهم زي ما شوفنا في الشبطة
+
+137
+00:09:42,490 --> 00:09:45,910
+الرقم اتنين هو المسؤول عن إنتاج الـ spermatocyte
+
+138
+00:09:45,910 --> 00:09:50,450
+Life Style زي ال smoking و الكفين و ال stress عندك
+
+139
+00:09:50,450 --> 00:09:53,230
+ال anatomical هنتكلم عنها زي ما اتكلمنا عنها عند
+
+140
+00:09:53,230 --> 00:09:58,650
+ال female و genetic بعض المشاكل الوراثية قد تؤدي
+
+141
+00:09:58,650 --> 00:10:05,250
+إلى ال infertility عند ال maleطبعاً هذا شكل بوضّح
+
+142
+00:10:05,250 --> 00:10:08,910
+و جدول بوضّح الـ Normal Value للـ Cement Parameter
+
+143
+00:10:08,910 --> 00:10:12,710
+الـ Liquefaction Time و هو وقت الإسالة تلاتين
+
+144
+00:10:12,710 --> 00:10:16,790
+minutes كحد أقصى الـ Ejaculation Fold Volume و هو
+
+145
+00:10:16,790 --> 00:10:20,910
+الحجم المقضوف لازم يكون أقل أقفل أكبر من أو يساوي
+
+146
+00:10:20,910 --> 00:10:26,050
+1.5 ملي لتر عند الـ Normal من الفسكوسة اللزوجة
+
+147
+00:10:26,050 --> 00:10:30,330
+لازم تعطيني Line خطب نسميها و هنعرف إيش يعني Line
+
+148
+00:10:31,010 --> 00:10:35,510
+طوله أقل من أو يسوى 2 cm هي ال line اللى بتخرج من
+
+149
+00:10:35,510 --> 00:10:38,770
+ال pipet ال plastic pipet اللى هنتكلم عنها ال
+
+150
+00:10:38,770 --> 00:10:43,030
+total sperm count يجب أن يكون أكبر من أو يسوى 39
+
+151
+00:10:43,030 --> 00:10:46,990
+مليون ال sperm concentration لازم يكون أكبر من أو
+
+152
+00:10:46,990 --> 00:10:51,150
+يسوى 15 مليون ال total motility لازم يكون أكبر من
+
+153
+00:10:51,150 --> 00:10:58,020
+أو تسوى 40%أكبر من أو تسوى 32% الـ viatility أو
+
+154
+00:10:58,020 --> 00:11:01,220
+الـ life sperm لازم العينة تحتوي على أكثر من أو
+
+155
+00:11:01,220 --> 00:11:06,120
+تسوى 58% أما بالنسبة للـ monormal form الشكل
+
+156
+00:11:06,120 --> 00:11:10,480
+الطبيعي للـ sperm يجب أن تحتوي العينة على أكثر من
+
+157
+00:11:10,480 --> 00:11:14,960
+40% من ال spermatocyte عفوا أكثر من 4% من ال
+
+158
+00:11:14,960 --> 00:11:19,500
+spermatocyte تكون normal form فبنال كل هذه ال
+
+159
+00:11:19,500 --> 00:11:24,310
+parameter مهمة هي في المنطق والمعقول مهمةولكن أكثر
+
+160
+00:11:24,310 --> 00:11:28,790
+ما نهتم فيه إيجا ال volume و ال sperm
+
+161
+00:11:28,790 --> 00:11:32,250
+concentration و ال total motility و المورفوليجي بس
+
+162
+00:11:32,250 --> 00:11:37,250
+في ال X المورفوليجي نسقط عنه أهم شيء ال motility و
+
+163
+00:11:37,250 --> 00:11:41,330
+ال concentration
+
+164
+00:11:41,330 --> 00:11:46,930
+صورة توضح ال step اللي احنا قسمناها pre analytical
+
+165
+00:11:46,930 --> 00:11:50,650
+و analytical و post analyticalأول حاجة في عندي الـ
+
+166
+00:11:50,650 --> 00:11:55,410
+Sample Collection وهي مسئولية المريض بحد أول
+
+167
+00:11:55,410 --> 00:11:59,850
+وبدرجة أولى الـ Technician وظيفته الأساسية يعطي
+
+168
+00:11:59,850 --> 00:12:04,950
+الـ Container Stripe ويقوله ويحكي له أهم التعليمات
+
+169
+00:12:04,950 --> 00:12:09,470
+اللازم أثناء جمع العينة تعطيه بعض التوصيات من
+
+170
+00:12:09,470 --> 00:12:14,740
+خلالها بيقدر يوصل العينة بشكل سليم 100%ممكن تجمع
+
+171
+00:12:14,740 --> 00:12:17,980
+الأينا في المكان، مكان إجراء الفحص أو في البيت بس
+
+172
+00:12:17,980 --> 00:12:21,620
+بشرط منطقة اللي هو فترة زمان يا بابينا وصولها
+
+173
+00:12:21,620 --> 00:12:25,620
+لمختبر وجامعة في البيت لا تقزيد عن نص ساعة أما
+
+174
+00:12:25,620 --> 00:12:29,320
+بالنسبة إلى عملية الـ Analysis وهي الـ Analytical
+
+175
+00:12:29,320 --> 00:12:33,820
+تقسم إلى قسمين Macro و Micro الـ Macro أي شيء أنا
+
+176
+00:12:33,820 --> 00:12:38,900
+بشوفه بالعين المجردة زي Liquefication Sample Age
+
+177
+00:12:38,900 --> 00:12:43,180
+يعني جمعت من ساعة، من ساعة و نصالـ Appearance، الـ
+
+178
+00:12:43,180 --> 00:12:47,440
+Volume، الـ Viscosity و الـ pH هذه تقسم macro أما
+
+179
+00:12:47,440 --> 00:12:50,820
+ال micro زي ال motility، ال concentration، ال
+
+180
+00:12:50,820 --> 00:12:56,020
+morphology، ال agglutination في بعض المصطلحات وبعض
+
+181
+00:12:56,020 --> 00:12:59,680
+الأطباء خليني أسميها وبعض المصطلحات الطبية التي
+
+182
+00:12:59,680 --> 00:13:05,760
+تستخدم تطلب من قبل أطباء كفحوصات مساعدة ولكنها
+
+183
+00:13:05,760 --> 00:13:11,840
+أساسية تحت عنوانHell paying test أو خلّيني أسميها
+
+184
+00:13:11,840 --> 00:13:15,140
+اوكي من أشهرها ال fractose نقيص نسبة ال fractose
+
+185
+00:13:15,140 --> 00:13:18,900
+في السمن الفلوينت و ال sperm و ال biatility جداش
+
+186
+00:13:18,900 --> 00:13:23,940
+عدد ال life sperm مهم جدا خصوصا أثناء عملية الإلاج
+
+187
+00:13:23,940 --> 00:13:30,020
+هذه أشهر المصطلحات اللي احنا هنواجهها خلال عملية
+
+188
+00:13:30,020 --> 00:13:35,740
+ال seminal analysisطبعاً عملية جمع العينة بشكل
+
+189
+00:13:35,740 --> 00:13:39,960
+أساسي تعتبر هي الـ critical step بمعنى آخر لو جمعت
+
+190
+00:13:39,960 --> 00:13:43,660
+العينة بطريقة غير سليمة فالنتيجة تلقائيا غير سليمة
+
+191
+00:13:43,660 --> 00:13:47,540
+وغير صحيحة فيجب أن تجمع العينة بطريقة سليمة طريقة
+
+192
+00:13:47,540 --> 00:13:52,640
+صحيحة 100% لكي تؤدي إلى إنتاج نتيجة سليمة وللعملية
+
+193
+00:13:52,640 --> 00:13:57,100
+الـ sample collection مسئولية المريض بحد أقصى وبحد
+
+194
+00:13:57,100 --> 00:14:01,400
+ودرجة أولى ولكن if liquification does not occur
+
+195
+00:14:01,400 --> 00:14:04,360
+probablyThe physical and chemical properties of
+
+196
+00:14:04,360 --> 00:14:10,340
+the seminal may be wrong or have a problem بمعنى
+
+197
+00:14:10,340 --> 00:14:14,300
+آخر، العينة الملطسة للمختبر لازم يصلها إسالة بشكل
+
+198
+00:14:14,300 --> 00:14:18,220
+سليم وصحيح إذا صارلها إسالة بشكل غير سليم وغير
+
+199
+00:14:18,220 --> 00:14:22,720
+صحيح، النتيجة تعتبر غير دقيقة من أهم الـ Adjacent
+
+200
+00:14:22,720 --> 00:14:25,340
+Test أو الـ Helping Test اللي احنا حكينا فيها الـ
+
+201
+00:14:25,340 --> 00:14:28,820
+Viatilityالـ lycoside الـ concentration of
+
+202
+00:14:28,820 --> 00:14:33,560
+fructose الـ concentration of fructose for example
+
+203
+00:14:33,560 --> 00:14:38,080
+هذه الـ most common الفحوصات التي يمكن أن تستخدم و
+
+204
+00:14:38,080 --> 00:14:42,940
+تطلب من قبل الطبيب للمساعدة في تشخص المرض سامبل
+
+205
+00:14:42,940 --> 00:14:47,120
+كولكشن تجمع العينة في container استلاءة استرايه
+
+206
+00:14:47,120 --> 00:14:50,240
+container with wide mouth مايعني wide mouth؟ يعني
+
+207
+00:14:50,240 --> 00:14:54,200
+فتحة ال container تكون واسعة ليس منطق تجمع في ال
+
+208
+00:14:54,200 --> 00:14:58,460
+test tube على سبيل المثاللازم تجمع في cup يشبه ال
+
+209
+00:14:58,460 --> 00:15:02,820
+urine cup ولكن استرالي دايما بكون cover red color
+
+210
+00:15:02,820 --> 00:15:07,620
+زي على سبيل المثال ال cup اللي يستخدم فيه ال urine
+
+211
+00:15:07,620 --> 00:15:15,560
+culture طبعا ممنوع انا ك technician لازم عليا انه
+
+212
+00:15:15,560 --> 00:15:20,080
+اقول للمريض انه يجب ان يمتنع عن جمع العين باستخدام
+
+213
+00:15:20,080 --> 00:15:24,200
+ال apricot او ال condom لان كلاهم في مواد قاتلة لل
+
+214
+00:15:24,200 --> 00:15:30,580
+sperm حاجة بتسميها spermSpermocidal agent تجمع
+
+215
+00:15:30,580 --> 00:15:33,600
+العينة بطريقة واحدة وأفضل الطرق على الإطلاق هي
+
+216
+00:15:33,600 --> 00:15:37,840
+طريقة ال master patient طريقة توتمت في مراكز
+
+217
+00:15:37,840 --> 00:15:42,740
+التلقيح الصيني العينة جميعها يجب أن تجمع في ال
+
+218
+00:15:42,740 --> 00:15:45,960
+container أي فقدر للعينة يجب أن يبلغ به ال
+
+219
+00:15:45,960 --> 00:15:49,560
+technician يعني بمعنى أخر المفروض يعمل ejaculation
+
+220
+00:15:49,560 --> 00:15:54,850
+لخمسة مل تم جمع أربعة مل إذا بكتب خمس أربعة ملخمسة
+
+221
+00:15:54,850 --> 00:15:58,970
+mil collected قسمين أربع mil received و one mil
+
+222
+00:15:58,970 --> 00:16:08,010
+مفقد ال time of collection مهم جدا لو أنا كمريد
+
+223
+00:16:08,010 --> 00:16:11,510
+جمعت العينة في المختبر لازم أبلغ التكنيشن بالوقت
+
+224
+00:16:11,510 --> 00:16:15,530
+اللي جمعت فيه العينة لو كمريد جمعت العينة في البيت
+
+225
+00:16:15,530 --> 00:16:18,930
+لازم أبلغ التكنيشن بالوقت اللي جمعت فيه العينة
+
+226
+00:16:18,930 --> 00:16:23,050
+سواء كان في البيتأو في المختبر عشان بناء عليه لازم
+
+227
+00:16:23,050 --> 00:16:28,130
+يحسب الـ liquification ال sample collection بمجرد
+
+228
+00:16:28,130 --> 00:16:30,550
+ما أحصل عليها لازم أكتب كل البيانات على ال
+
+229
+00:16:30,550 --> 00:16:34,390
+container و أدخلها في ال incubator على 37 درجة
+
+230
+00:16:34,390 --> 00:16:38,790
+موية من أجل ال liquification ثم أبدأ فيما بعد بال
+
+231
+00:16:38,790 --> 00:16:43,930
+macroscopic analysis اللي لازم يتم خلال فترة زمنية
+
+232
+00:16:43,930 --> 00:16:48,200
+من نصها على تلقى 60دقيقة خلال هذه الفترة الزمنية
+
+233
+00:16:48,200 --> 00:16:52,500
+لازم كل ال macroscopic examination أو analysis
+
+234
+00:16:52,500 --> 00:16:58,640
+تكون أنهيت منها بشكل كامل زي الviscosity زي ال pH
+
+235
+00:16:58,640 --> 00:17:04,000
+زي ال color زي ال volume وخلافه The most important
+
+236
+00:17:04,000 --> 00:17:06,980
+issue of the sample collection is the absent time
+
+237
+00:17:06,980 --> 00:17:10,880
+the number of days without ejaculation مهم جدا
+
+238
+00:17:10,880 --> 00:17:15,830
+بشكل كبير جدا أنهتجمع العينة بعد امتناع عن ال
+
+239
+00:17:15,830 --> 00:17:19,270
+ejaculation أو عن ال intercourse بفترة زمنية معينة
+
+240
+00:17:19,270 --> 00:17:24,570
+أقلها تلت أيام، أكثرها خمس أيام ولكن معظم المراكز
+
+241
+00:17:24,570 --> 00:17:27,410
+تستعمل أن يجب على المريض الامتناع عن ال
+
+242
+00:17:27,410 --> 00:17:31,430
+ejaculation أو ال intercourse تلت أيام بشكل أساسي
+
+243
+00:17:31,430 --> 00:17:34,970
+في اليوم التالت بيجمع العينة في نهاية اليوم التالت
+
+244
+00:17:34,970 --> 00:17:38,340
+أو بعض الاحيان بيقولك في بداية اليوم الرابعالمهم
+
+245
+00:17:38,340 --> 00:17:41,820
+يكون له تلات أيام ممتنة before sample collection
+
+246
+00:17:41,820 --> 00:17:44,840
+spermatozoa are stored in the epidermis until
+
+247
+00:17:44,840 --> 00:17:50,180
+ejaculation however, the epidermal storage is not
+
+248
+00:17:50,180 --> 00:17:53,200
+completely empty in the single ejaculation and the
+
+249
+00:17:53,200 --> 00:17:56,240
+remaining spermatozoa stay until the next
+
+250
+00:17:56,240 --> 00:18:00,560
+ejaculation كون على ثقة إن صحيح إن ال spermatozoa
+
+251
+00:18:00,560 --> 00:18:04,920
+تخزن في ال epidermis ولكن خلال ال ejaculationاللي
+
+252
+00:18:04,920 --> 00:18:08,860
+بيعطيها الـ 105 أو 3 أو 4 ميل ما بيطلع كل المخزون
+
+253
+00:18:08,860 --> 00:18:14,920
+جزء منه يبقى لـ Ejaculation التالية علشان كده مهم
+
+254
+00:18:14,920 --> 00:18:21,180
+جدا أكون هذه المعلومة في نص عيني ويبقى على دراية
+
+255
+00:18:21,180 --> 00:18:26,420
+فيها علشان أقدر أقيم بشكل سليم Ideal duration of
+
+256
+00:18:26,420 --> 00:18:32,120
+sexual absence2 to 3 days و لكن الكل متفق على تلت
+
+257
+00:18:32,120 --> 00:18:35,100
+أيام معظمهم متفق على تلت أيام يجب على المريض اللي
+
+258
+00:18:35,100 --> 00:18:39,460
+مدينة عنه ejaculation أو الintercourses تلت أيام
+
+259
+00:18:39,460 --> 00:18:45,320
+طيب لو أنا بدي أعمل تحليل آخر كقبيل طلب تحليل آخر
+
+260
+00:18:45,320 --> 00:18:50,100
+المريض يجمع العينة مباشرة ولا ينتظر فترة لازم
+
+261
+00:18:50,100 --> 00:18:55,060
+المريض ينتظر فترة أقلها سبوعين يعني التحليل الأول
+
+262
+00:18:55,060 --> 00:18:58,280
+كان في واحد عشرة التحليل التاني لازم يكون في أربع
+
+263
+00:18:58,280 --> 00:19:02,770
+تاشر عشرةيعني بمعنى أخر بين التحليل الأول والتاني
+
+264
+00:19:02,770 --> 00:19:08,870
+أسبوعين هي نقطة تجمع بنفس الطريقة هي نقطتين تجمع
+
+265
+00:19:08,870 --> 00:19:12,470
+بنفس ال absence of intercourse أو ال sexual
+
+266
+00:19:12,470 --> 00:19:15,110
+absence في المرة الأولى امتنع يومين في المرة
+
+267
+00:19:15,110 --> 00:19:17,490
+التانية لازم امتنع يومين في المرة الأولى امتنع
+
+268
+00:19:17,490 --> 00:19:20,670
+تلاتة في المرة التانية لازم امتنع تلت أيام علشان
+
+269
+00:19:20,670 --> 00:19:25,210
+يصير في عندي نوع من أنواع ال bias اتجنبهتجنب الـ
+
+270
+00:19:25,210 --> 00:19:28,730
+bias أو الـ interfere اللي ممكن تتصير ال interval
+
+271
+00:19:28,730 --> 00:19:31,350
+between separated C من ال analysis is generally
+
+272
+00:19:31,350 --> 00:19:36,070
+recommended to be two to four weeks ولكن الكل متفق
+
+273
+00:19:36,070 --> 00:19:40,190
+أنه أقل شي أسبوعين فبالتالي أسبوعين و إيام مينفع
+
+274
+00:19:40,190 --> 00:19:43,750
+معاك من أسبوعين لأربع أسبوع كمريل ولكن الكل متفق
+
+275
+00:19:43,750 --> 00:19:46,650
+زي ما هو متفق على تلت أيام sexual absence الكل
+
+276
+00:19:46,650 --> 00:19:51,490
+متفق على تلت أسبوعين ما بين العينة الأولى و العينة
+
+277
+00:19:51,490 --> 00:19:52,670
+التالية
+
+278
+00:19:54,630 --> 00:19:58,050
+نبدأ بأول نقطة إلى علاقة بالـ macroscopic
+
+279
+00:19:58,050 --> 00:20:00,970
+evaluation كيف يمكن تحديد الـ macroscopic
+
+280
+00:20:00,970 --> 00:20:03,970
+evaluation؟ بمعنى آخر، هل يمكن تحديد الـ
+
+281
+00:20:03,970 --> 00:20:07,770
+macroscopic evaluation؟ وما هي؟ أول test له علاقة
+
+282
+00:20:07,770 --> 00:20:10,970
+بالـ macroscopic الـ liquefication، وهي الإسالة
+
+283
+00:20:10,970 --> 00:20:17,850
+الإسالة هي تحول الـ seminal fluid من شكل الكتل إلى
+
+284
+00:20:17,850 --> 00:20:21,490
+شكل liquid من الشكل الـ semisolid إلى شكل الـ
+
+285
+00:20:21,490 --> 00:20:21,650
+liquid
+
+286
+00:20:26,220 --> 00:20:31,500
+الـ Semen بيخرج على شكل دفقات هي عبارة محاطة بكمية
+
+287
+00:20:31,500 --> 00:20:35,700
+من البروتين لتحميه من ال external environment أو
+
+288
+00:20:35,700 --> 00:20:40,040
+external factor بالإضافة إلى ال environment
+
+289
+00:20:40,040 --> 00:20:43,100
+المختلفة الموجودة في ال reproductive tract الخاصة
+
+290
+00:20:43,100 --> 00:20:47,320
+بالفيميل فبالتالي after ejaculation human semen
+
+291
+00:20:47,320 --> 00:20:51,600
+form lose gel-like coagulant in a few seconds by
+
+292
+00:20:51,600 --> 00:20:55,790
+cross-linking of seminal vesicle proteinلذن السمنة
+
+293
+00:20:55,790 --> 00:20:59,170
+الـ fluid بمجرد خروجه من جسم الإنسان بيتحول من
+
+294
+00:20:59,170 --> 00:21:02,430
+القوام الجيلاتيني الجلي إلى القوام السائل بفعل
+
+295
+00:21:02,430 --> 00:21:05,810
+إنزيمات وبروتينات موجودة في السمنة الـ fluid من
+
+296
+00:21:05,810 --> 00:21:11,450
+أشارها السينوكليين 1 و 2 و الفيبرينوكتين as
+
+297
+00:21:11,450 --> 00:21:17,170
+protein the formation of coagulant مهم جدا، ماهو
+
+298
+00:21:17,170 --> 00:21:20,150
+هدف الـ coagulant؟ ماهو هدف المادة الجيلاتينية
+
+299
+00:21:20,150 --> 00:21:26,370
+التي تحيط بالسمنة بال spermatozoaأو بـ sperm حكينا
+
+300
+00:21:26,370 --> 00:21:32,530
+أول شغلة بتعمل على تقليل معدل خروج السمن الفلود من
+
+301
+00:21:32,530 --> 00:21:36,150
+منطقة الفاجينة فهذا بيزيد من فرصة ال fertilization
+
+302
+00:21:36,150 --> 00:21:39,910
+to minimize the backflow يعني التطفق للخارج أو
+
+303
+00:21:39,910 --> 00:21:44,810
+للخلف بعد التبوسيت في الفاجينة نقطة تانية to
+
+304
+00:21:44,810 --> 00:21:50,850
+protect the spermatozoa or sperm from the acidic
+
+305
+00:21:50,850 --> 00:21:55,170
+pH of vaginaand to protect them from immune attack
+
+306
+00:21:55,170 --> 00:21:59,670
+يعني تلت أسباب ووظائف للـ coagulant المادة
+
+307
+00:21:59,670 --> 00:22:02,590
+الجلوتانية التي تحيط بالـ sperm حماية من الـ
+
+308
+00:22:02,590 --> 00:22:05,450
+acidic pH الموجودة في الفاجينة حماية من ال immune
+
+309
+00:22:05,450 --> 00:22:09,390
+system attack أو الimmune attack ومنع ال back
+
+310
+00:22:09,390 --> 00:22:15,050
+follow بعد الدوبوزيشن اللي بيصير في الفاجينةمادة
+
+311
+00:22:15,050 --> 00:22:17,650
+أخرى موجودة في الـ seminal fluid وتساعد على
+
+312
+00:22:17,650 --> 00:22:22,090
+الليكوفيكاشن هي البروستاتا specific antigen بقعة
+
+313
+00:22:22,090 --> 00:22:25,950
+اللي عاوز أسموها البروستاتيك specific antigen ABCA
+
+314
+00:22:25,950 --> 00:22:30,510
+هذه تلعب
+
+315
+00:22:30,510 --> 00:22:35,390
+دور كبير جدا ومهم في تكسير الكواكولوم علشان تعمل
+
+316
+00:22:35,390 --> 00:22:41,730
+تحرر للسبيرماتوزوة مصدرها بشكل أساسي لبروستاتا في
+
+317
+00:22:41,730 --> 00:22:46,010
+أيضا مادة أخرىالـ Vibrinolysis Vibrinolysis هو
+
+318
+00:22:46,010 --> 00:22:50,570
+عبارة عن بروتاليتك إنزين يفرز أيضًا من البرستاتا
+
+319
+00:22:50,570 --> 00:22:54,290
+وبيلعب دور مهم جدًا في تكسير الفيبرين المسؤول عن
+
+320
+00:22:54,290 --> 00:22:58,870
+تكوين الـ coagulant which lycophytes the seminal
+
+321
+00:22:58,870 --> 00:23:01,790
+within fifty to thirty minutes the function of
+
+322
+00:23:01,790 --> 00:23:05,790
+this enzyme is gradual طبعًا البرستاتك ال specific
+
+323
+00:23:05,790 --> 00:23:08,330
+انتجن أو البرستاتك ال specific انتجن و ال
+
+324
+00:23:08,330 --> 00:23:12,670
+Vibrinolysis ال Vibrinolysin as enzymeما بيشتغلوا
+
+325
+00:23:12,670 --> 00:23:18,610
+بشكل مفاجئ، لأ بشكل تدريجي ما بيقطع منطقة الـ
+
+326
+00:23:18,610 --> 00:23:21,890
+cervical إلا بيكون صارله complete liquefaction هذا
+
+327
+00:23:21,890 --> 00:23:25,890
+بالوضع الطبيعي، عشان كده بتاخد من 15 أقل شيء إلى
+
+328
+00:23:25,890 --> 00:23:30,590
+30 الـ liquefaction كان okay رأي رومتون بريتشار
+
+329
+00:23:30,880 --> 00:23:36,280
+ويمكننا إستعمال ذلك باستخدام مخزن لدرجة 37 دقائق
+
+330
+00:23:36,280 --> 00:23:37,960
+مستمر في المزيد من المزيد من المزيد من المزيد من
+
+331
+00:23:37,960 --> 00:23:40,380
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+332
+00:23:40,380 --> 00:23:40,820
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+333
+00:23:40,820 --> 00:23:47,520
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+334
+00:23:47,520 --> 00:23:51,480
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+335
+00:23:51,480 --> 00:23:51,500
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+336
+00:23:51,500 --> 00:23:58,010
+المزيد من المزيد من المزيد من المزيدالprocess of
+
+337
+00:23:58,010 --> 00:24:01,050
+liquefaction is significant as it allows for
+
+338
+00:24:01,050 --> 00:24:04,410
+impolized sperm to become motile مهم جدا عشان تسمح
+
+339
+00:24:04,410 --> 00:24:07,790
+للـ spermatozoa أنها تتحرك، ما تكون عالقة داخل
+
+340
+00:24:07,790 --> 00:24:12,110
+الشبكة، if the semen fails to liquefy it, it can
+
+341
+00:24:12,110 --> 00:24:17,670
+be indicative of a glandular dysfunction of the
+
+342
+00:24:17,670 --> 00:24:20,750
+prostata والله بعد نص ساعة ما أصلحش liquefaction
+
+343
+00:24:20,750 --> 00:24:24,780
+لعينة، استنيت كمان 35، كمان 5 دقايقخمس و تلاتين،
+
+344
+00:24:24,780 --> 00:24:27,440
+اربعين، خمس و اربعين، خمسين ماصارش liquefication
+
+345
+00:24:27,440 --> 00:24:30,820
+إذا أنا بعرف إن فيه أنا عندي مشكلة في البروستاتا
+
+346
+00:24:30,820 --> 00:24:33,720
+لإن هي اللي بتفرز البروستاتا ال specific antigen و
+
+347
+00:24:33,720 --> 00:24:37,760
+ال fibrinolysis أو fibrinolysin as a proteolytic
+
+348
+00:24:37,760 --> 00:24:40,720
+enzyme معناه في عندي dysfunction اللي فيه
+
+349
+00:24:40,720 --> 00:24:45,020
+البروستاتا ال abnormality الخاصة بال liquefication
+
+350
+00:24:45,020 --> 00:24:49,360
+أسبابها عندي ejaculatory duct obstruction في عندي
+
+351
+00:24:49,360 --> 00:24:51,400
+obstruction في ال ejaculatory duct في القضايا
+
+352
+00:24:51,400 --> 00:24:56,070
+القادرةفيها اندى congenital absence للسمن physical
+
+353
+00:24:56,070 --> 00:25:00,690
+الناقل أو فيها اندى genital tract infection وهي
+
+354
+00:25:00,690 --> 00:25:06,370
+تعتبر من أكثر الأسباب شيوعا لحدوث elongation in
+
+355
+00:25:06,370 --> 00:25:09,850
+the duration of .. in the duration time of السمن
+
+356
+00:25:09,850 --> 00:25:13,670
+liquification يعني زيادة أكثر الأسباب انتشارا
+
+357
+00:25:13,670 --> 00:25:19,230
+والتي تؤدي إلى زيادة الوقت المستهلك لتميُع السائل
+
+358
+00:25:19,230 --> 00:25:25,630
+هي عبارة عن ال genital tract infectionالنوع التاني
+
+359
+00:25:25,630 --> 00:25:28,850
+أو ال test التاني من ال macroscopic هي عبارة عن ال
+
+360
+00:25:28,850 --> 00:25:32,910
+viscosity اللزوجة طبعا after liquification تصل
+
+361
+00:25:32,910 --> 00:25:36,210
+liquification بعد نص ساعة كل الفحوصات مباحة يعني
+
+362
+00:25:36,210 --> 00:25:39,450
+ممكن أنت تستطيع أن تعمل أي فحص بعد ال
+
+363
+00:25:39,450 --> 00:25:41,930
+liquification قبل ال liquification ممنوع تعمل أي
+
+364
+00:25:41,930 --> 00:25:46,050
+فحص حتى لو كان فحص بسيط جدا ال viscosity referred
+
+365
+00:25:46,050 --> 00:25:49,390
+to elastic properties of the sample after
+
+366
+00:25:49,390 --> 00:25:53,110
+liquification يعني أنا بشوف ميعدتها كيف؟ بشوف
+
+367
+00:25:53,110 --> 00:25:56,700
+لزوجتها كيف؟بشوف قوامها كيف، قوام مين؟ قوام العينة
+
+368
+00:25:56,700 --> 00:25:59,380
+اللي عبارة عن السمن طب كيف بتعملها عملية
+
+369
+00:25:59,380 --> 00:26:02,740
+evaluation ببساطة جدا بجيب dropper، plastic
+
+370
+00:26:02,740 --> 00:26:07,060
+dropper، استراعي بعمل mixing و باخد العينة كلها و
+
+371
+00:26:07,060 --> 00:26:11,780
+برفع إيدي و بعمل dropping بشوف السمن ال fluid بنزل
+
+372
+00:26:11,780 --> 00:26:15,840
+قطرة قطرة ولا بنزل على هذه ال line و ال line اللي
+
+373
+00:26:15,840 --> 00:26:19,240
+بنزل جدش تورو تقديرا، مش بجيب مصدر وقيص، لأ تقديرا
+
+374
+00:26:19,240 --> 00:26:23,960
+فإذا كانت بنزل drop by dropمعناه انه liquification
+
+375
+00:26:23,960 --> 00:26:29,020
+طبيعية و الviscosity طبيعية والله نزل على شكل ال
+
+376
+00:26:29,020 --> 00:26:33,300
+line طوله 2 cm تقريبا إذا بسميها hyperviscosity من
+
+377
+00:26:33,300 --> 00:26:37,220
+2 إلى 4 slightly hyperviscosity من 4 إلى 6
+
+378
+00:26:37,220 --> 00:26:42,500
+moderate hyperviscosity أكتر من 6 cm معناها higher
+
+379
+00:26:42,500 --> 00:26:48,380
+hyperviscosity هذه فكرة الviscosity معظمه يكون ما
+
+380
+00:26:48,380 --> 00:26:52,830
+بين hyper و slightlyولكن في ناس بتكون normal drop
+
+381
+00:26:52,830 --> 00:26:57,710
+by drop الـ abnormal viscosity وجدوا أنها لها
+
+382
+00:26:57,710 --> 00:27:03,030
+علاقة بأمر معين وهو hypofunction of prostata or
+
+383
+00:27:03,030 --> 00:27:06,450
+seminal vesicle يعني عندي reduction في الـ
+
+384
+00:27:06,450 --> 00:27:10,530
+functional المتعلقة بالبرستاتكي gland و ال seminal
+
+385
+00:27:10,530 --> 00:27:14,610
+vesicle علما عندي مشكلة في ال functional إذا كلا
+
+386
+00:27:14,610 --> 00:27:16,790
+المنطقتين سواء كانت البرستاتا أو ال seminal
+
+387
+00:27:16,790 --> 00:27:21,180
+vesicle لن تستطيع إخراج محتوىهافبالتالي، هيكون
+
+388
+00:27:21,180 --> 00:27:23,360
+عندي مشكلة في الـ liquefication ومشكلة في
+
+389
+00:27:23,360 --> 00:27:26,460
+الviscosity on the other hand, infection and
+
+390
+00:27:26,460 --> 00:27:30,100
+inflammation of accessory gland or other male
+
+391
+00:27:30,100 --> 00:27:32,860
+fertility related disease may also lead to semen
+
+392
+00:27:32,860 --> 00:27:36,800
+hyperviscosity in men with functionally normal
+
+393
+00:27:36,800 --> 00:27:40,760
+accessory gland في بعض الأحيان، ممكن يكون عندي ال
+
+394
+00:27:40,760 --> 00:27:44,680
+functional gland normal 100%ولكن في مشكلة عندى في
+
+395
+00:27:44,680 --> 00:27:47,720
+الviscosity بيكون سببها infection او inflammation
+
+396
+00:27:47,720 --> 00:27:51,900
+في ال accessary gland فممكن انا اطلق عليها و
+
+397
+00:27:51,900 --> 00:27:55,640
+اشخصها عفوا من خلال اعمل مظرة على ال seminal fluid
+
+398
+00:27:55,640 --> 00:27:59,860
+زي ما بعمل مظرة على ال urine بعمل مظرة على ال
+
+399
+00:27:59,860 --> 00:28:04,680
+seminal fluid ال hyperviscosity has been shown to
+
+400
+00:28:04,680 --> 00:28:07,980
+be ايش ال hyperviscosity اسبابها what is the
+
+401
+00:28:07,980 --> 00:28:11,460
+reasons of hyperviscosity اول حاجة وجدوا انها
+
+402
+00:28:11,460 --> 00:28:17,790
+associated% of motility spermatozoa بمعنى آخر
+
+403
+00:28:17,790 --> 00:28:20,890
+خلّيني أسميها رغم إن عرفنا في النقطة الأولى
+
+404
+00:28:20,890 --> 00:28:25,530
+أسبابها زي الـ Hypofunctional Prostatic أو الـ
+
+405
+00:28:25,530 --> 00:28:27,750
+Hypofunctional Seminal Vesicle أو عنده
+
+406
+00:28:27,750 --> 00:28:30,890
+Inflammation أو Infection طب الـ Hyperfiscosity
+
+407
+00:28:30,890 --> 00:28:36,350
+لإيش تؤدي؟ إيش مخاطرها؟ إيش الـ side effect تبعها؟
+
+408
+00:28:36,350 --> 00:28:40,460
+الـ side effect أول حاجة بتعملي لاورأو الـ
+
+409
+00:28:40,460 --> 00:28:43,580
+reduction in the percentage of motile sperm نسبة
+
+410
+00:28:43,580 --> 00:28:46,060
+الـ motile sperm بتكون قليلة جدا لإن ال sperm
+
+411
+00:28:46,060 --> 00:28:52,020
+بيكون محصور داخل شبكة اتنين indicative of a
+
+412
+00:28:52,020 --> 00:28:54,700
+deficiency in the functional activity of accessory
+
+413
+00:28:54,700 --> 00:28:58,340
+6 glands لما تكون ال viscosity عالية معناه أنه أنا
+
+414
+00:28:58,340 --> 00:29:02,760
+عند مشكلة في وظائف الغدد الجنسية أو الغدد المساعدة
+
+415
+00:29:02,760 --> 00:29:08,520
+ل ال reproductive system عند المن نجلد نوع تالت من
+
+416
+00:29:08,520 --> 00:29:14,010
+أنواعالـ Macroscopic Examination و هو الـ pH طبعا
+
+417
+00:29:14,010 --> 00:29:18,170
+في عندي accessor gland أو accessor 6 gland هي التي
+
+418
+00:29:18,170 --> 00:29:23,930
+تساهم في إنتاج الـ pH الخاص بالـ seminal fluid على
+
+419
+00:29:23,930 --> 00:29:28,070
+سبيل المثال الـ seminal is multiglandular in
+
+420
+00:29:28,070 --> 00:29:31,050
+origin with the acetic prostata and alkaline
+
+421
+00:29:31,050 --> 00:29:36,330
+seminal vesicle يعني البرستاتة بتفرز fluid acid و
+
+422
+00:29:36,330 --> 00:29:37,950
+ال seminal vesicle بتفرز
+
+423
+00:29:41,680 --> 00:29:46,440
+مين بتغير تاني بيديني تكوين الـ pH الخاص بالسمن
+
+424
+00:29:46,440 --> 00:29:51,440
+وهو high pH يعني ايش يعني high pH؟ يعني أكبر من 7
+
+425
+00:29:51,440 --> 00:29:56,340
+يعني alkaline combining to produce alkaline fluid
+
+426
+00:29:56,340 --> 00:30:01,200
+with the high pH range from 7.2 ل 8 إذا نخدوا
+
+427
+00:30:01,200 --> 00:30:04,720
+بالكم هنا من النقطة صحيح إنه في عندك بروستاتا
+
+428
+00:30:04,720 --> 00:30:08,660
+بتتفرز acidic fluid وصحيح عندك في سمنال physically
+
+429
+00:30:08,660 --> 00:30:12,420
+بتتفرز alkaline fluidوالاتنين الـ fluid يلتقوا في
+
+430
+00:30:12,420 --> 00:30:16,840
+مجلة واحد وهو الـ ejaculatory duct ولكن الـ pH تبع
+
+431
+00:30:16,840 --> 00:30:20,240
+الـ seminal physical يطغى على الـ pH تبع ال
+
+432
+00:30:20,240 --> 00:30:23,440
+prostatic لأن كمية ال fluid اللي جاي من ال seminal
+
+433
+00:30:23,440 --> 00:30:27,660
+physical أعلى فبالتالي بيعطي ال pH ال alkaline
+
+434
+00:30:27,660 --> 00:30:32,920
+الخاص بال seminal fluid ال pH اللي ليه عبارة من 7
+
+435
+00:30:32,920 --> 00:30:41,720
+.2 ل 8 ال pH إذا كان أقل من 7 بكون أسبابهاأو تقنين
+
+436
+00:30:41,720 --> 00:30:45,740
+مؤشر أنه في congenital absent في ال vas deferens
+
+437
+00:30:45,740 --> 00:30:49,680
+أو obstruction في ال ejaculatory duct يعني لما أجى
+
+438
+00:30:49,680 --> 00:30:52,960
+ال pH على طريق ال stream أقل من 7 تقسم من ال fluid
+
+439
+00:30:52,960 --> 00:30:57,580
+بقول والله ممكن يكون absent في ال congenital أو
+
+440
+00:30:57,580 --> 00:31:00,420
+يعني بمعنى absent في ال vas deferens وهذا طبيعة ال
+
+441
+00:31:00,420 --> 00:31:03,840
+absent congenital يعني الذكر هذا مولود بال absent
+
+442
+00:31:03,840 --> 00:31:08,400
+منذ الولادة أو في عندي انسداد في ال ejaculatory
+
+443
+00:31:08,400 --> 00:31:15,620
+duct القناة القادفةلو زاد ال pH عن 7.8 أو زاد عن 8
+
+444
+00:31:15,620 --> 00:31:19,620
+صار more alkaline أسبابها أو بيعطيني indication
+
+445
+00:31:19,620 --> 00:31:22,120
+أنه و الله عندي فيه مشكلة في ال seminal vesicle
+
+446
+00:31:22,120 --> 00:31:25,560
+حاجة بنسميها dysfunctional seminal vesicle
+
+447
+00:31:25,560 --> 00:31:30,260
+dysfunctional seminal vesicle إذن ال normal range
+
+448
+00:31:30,260 --> 00:31:34,340
+عرفناه لل pH لل seminal fluid إن زاد ال pH و إن قل
+
+449
+00:31:34,340 --> 00:31:38,940
+ال pH بيعتبر indicative و indication على شو بالضبط
+
+450
+00:31:40,780 --> 00:31:44,220
+كدا بيكون خلصنا ال microscopic التي تورا بالعين
+
+451
+00:31:44,220 --> 00:31:48,680
+المجردة سننتقل إلى موضوع جديد له علاقة بال
+
+452
+00:31:48,680 --> 00:31:53,740
+microscopic examination و هذا الكلام ان شاء الله
+
+453
+00:31:53,740 --> 00:32:00,640
+هنمشي فيه بخطة على أمل انه نبسط بعض النقاط ال
+
+454
+00:32:00,640 --> 00:32:04,140
+microscopic examination أول مصطلح اللي بنحكي فيه و
+
+455
+00:32:04,140 --> 00:32:08,940
+هو أهم مصطلح هو ال spare concentration خدوا بالك
+
+456
+00:32:08,940 --> 00:32:14,200
+keep in your mindThere are two terms sperm
+
+457
+00:32:14,200 --> 00:32:18,460
+concentration and total sperm count دولة different
+
+458
+00:32:18,460 --> 00:32:24,360
+term sperm concentration معناه ببساطة عدد
+
+459
+00:32:24,360 --> 00:32:28,540
+الحيوانات في ملي لتر واحد يعني انا عندى ملي لتر
+
+460
+00:32:28,540 --> 00:32:31,760
+واحد اكتر حيوان منوي اكتر نطفة موجودة عندى هذا
+
+461
+00:32:31,760 --> 00:32:37,600
+بسميها لإنه صار في حجم معين و هو one milliliter
+
+462
+00:32:37,600 --> 00:32:42,430
+بسميه sperm concentration ال spermالـ total count
+
+463
+00:32:42,430 --> 00:32:46,150
+هو عبارة عن عدد الحيوانات المنوية في العينة ككل
+
+464
+00:32:46,150 --> 00:32:51,210
+كيف تحسب؟ بقول ال total sperm count يساوي ال sperm
+
+465
+00:32:51,210 --> 00:32:54,910
+concentration ضرب ال total volume يعني لو أنا اللي
+
+466
+00:32:54,910 --> 00:32:59,050
+جيت ببساطة عندي خمسة مليون as sperm concentration
+
+467
+00:32:59,050 --> 00:33:02,610
+في الواحد مل وعندي ال total volume خمسة إذا ال
+
+468
+00:33:02,610 --> 00:33:07,660
+total sperm count خمسة في خمسة وعشرين مليونSperm
+
+469
+00:33:07,660 --> 00:33:12,100
+concentration can be assessed by homocytometer هذه
+
+470
+00:33:12,100 --> 00:33:14,960
+طريقة من طرق القياس وهي التي تعتبر reference
+
+471
+00:33:14,960 --> 00:33:20,180
+method ال macular هو عبارة عن slide خاصة بال
+
+472
+00:33:20,180 --> 00:33:24,200
+seminal fluid يستخدم في ال fertility center وال
+
+473
+00:33:24,200 --> 00:33:28,260
+slide method وهي عبارة عن طريقة روتينية لها طريقة
+
+474
+00:33:28,260 --> 00:33:33,920
+معينة في القياس الأصح يابتستخدم macular يابتستخدم
+
+475
+00:33:33,920 --> 00:33:38,490
+homocytometer هذا صحThe concentration of the semen
+
+476
+00:33:38,490 --> 00:33:43,110
+depending on what يعني عدد الحيوانات في ال one
+
+477
+00:33:43,110 --> 00:33:46,790
+milliliter تعتمد على شغل أول حاجة تعتمد على volume
+
+478
+00:33:46,790 --> 00:33:50,450
+of testis حجم ال testis جدش كل ما زاد الحجم
+
+479
+00:33:50,450 --> 00:33:55,210
+المنطقي يقول هيزيد عملية التصنيع، هيزيد المخزون،
+
+480
+00:33:55,210 --> 00:34:00,070
+هيزيد عدد الحيوانات المقضوفة اتنين ال period of
+
+481
+00:34:00,070 --> 00:34:03,550
+sexual absence هل امتنع عن ال intercourse أو ال
+
+482
+00:34:03,550 --> 00:34:06,630
+ejaculation تلت أيام ولا أسبوع؟طبعاً هذا منطق كل
+
+483
+00:34:06,630 --> 00:34:09,950
+ما زاد الإمتناع زادت عملية التحصيل والتخزين
+
+484
+00:34:09,950 --> 00:34:14,890
+فبالتالي زاد عملية ال sperm اللي مقضوف ال size of
+
+485
+00:34:14,890 --> 00:34:19,930
+epidermal sperm منطقي كل ما زاد ال size يعني كل ما
+
+486
+00:34:19,930 --> 00:34:23,910
+زاد المستودع كل ما زادت عملية التخزين إذن تلت عوام
+
+487
+00:34:23,910 --> 00:34:29,030
+الأساسية هي التي تساهم وتعتمد عليها عدد الحيوانات
+
+488
+00:34:29,030 --> 00:34:32,770
+المنوية أو ما يُعرف باسم ال sperm concentration
+
+489
+00:34:32,770 --> 00:34:40,660
+sperm morphologyمن أشهر وأهم الـ Parameter احنا
+
+490
+00:34:40,660 --> 00:34:43,660
+عارفين دايما ان الـSperm بتكون من head و neck و
+
+491
+00:34:43,660 --> 00:34:47,460
+mid piece و tail ال head فيه الأكرزوم و فيه ال
+
+492
+00:34:47,460 --> 00:34:53,720
+nuclear acid ال mid piece فيها متاكندرية و ال
+
+493
+00:34:53,720 --> 00:34:57,420
+flagella أو ال tail مسئولة عن الحركة طبعا هذه
+
+494
+00:34:57,420 --> 00:35:00,220
+الصورة هي عبارة عن ال normal shape او ال normal
+
+495
+00:35:00,220 --> 00:35:04,560
+form لـSpermفي بعض الأحيان في عندي abnormal form
+
+496
+00:35:04,560 --> 00:35:10,940
+زي زيادة في ال head size نقصان في ال head size
+
+497
+00:35:10,940 --> 00:35:20,520
+نقصان في ال head size نقصان في ال head size نقصان
+
+498
+00:35:20,520 --> 00:35:22,080
+في ال head size نقصان في ال head size نقصان في ال
+
+499
+00:35:22,080 --> 00:35:22,320
+head size نقصان في ال head size نقصان في ال head
+
+500
+00:35:22,320 --> 00:35:22,420
+size نقصان في ال head size نقصان في ال head size
+
+501
+00:35:22,420 --> 00:35:23,260
+نقصان في ال head size نقصان في ال head size نقصان
+
+502
+00:35:23,260 --> 00:35:25,060
+في ال head size نقصان في ال head size نقصان في ال
+
+503
+00:35:25,060 --> 00:35:26,240
+head size نقصان في ال head size نقصان في ال head
+
+504
+00:35:26,240 --> 00:35:28,540
+size نقصان في ال head size نقصان في ال head size
+
+505
+00:35:28,540 --> 00:35:29,880
+نقصان في ال head size نقصان في ال head size نقصان
+
+506
+00:35:29,880 --> 00:35:31,560
+head size نقصان في ال head size نقabnormal
+
+507
+00:35:31,560 --> 00:35:35,420
+morphology may have an impact on هذه الـ abnormal
+
+508
+00:35:35,420 --> 00:35:37,760
+morphology لما أشوف abnormality عالية في الـ
+
+509
+00:35:37,760 --> 00:35:41,180
+morphology للـ sperm تعطيلي indication على شو؟
+
+510
+00:35:41,180 --> 00:35:44,740
+تعطيلي إن في عندي chromatin condensation بشكل غير
+
+511
+00:35:44,740 --> 00:35:50,180
+طبيعي في عندي أكرزوم أو عفوًا بتأثر على شو؟ بتعمل
+
+512
+00:35:50,180 --> 00:35:53,480
+impact على شو؟ لما يكون عندي abnormality في ال
+
+513
+00:35:53,480 --> 00:35:54,020
+morphology
+
+514
+00:36:10,230 --> 00:36:16,610
+الحركة نشاط الأكرزوم الاببتوسس كلهم يتأثروا
+
+515
+00:36:16,610 --> 00:36:19,590
+بالمورفولوجي يعني بمعنى آخر أن المورفولوجي السيء
+
+516
+00:36:19,590 --> 00:36:23,950
+يتأثر عليه بشكل سيءSpecific morphological defects
+
+517
+00:36:23,950 --> 00:36:29,170
+such as multiple tail abnormalities or headless
+
+518
+00:36:29,170 --> 00:36:33,870
+spermatozoa may be associated with genetic
+
+519
+00:36:33,870 --> 00:36:37,650
+abnormality يعني في عندي بعض الـ abnormal form
+
+520
+00:36:37,650 --> 00:36:41,670
+اللي علاقة بالgenetic زي فقدان ال head على سبيل
+
+521
+00:36:41,670 --> 00:36:46,070
+المثال أو وجود أكتر من tail وجود أكتر من tail زي
+
+522
+00:36:46,070 --> 00:36:50,210
+ما أحنا شايفين في رقم تلاتة من جهة اليمين قد يكون
+
+523
+00:36:50,210 --> 00:36:55,370
+genetical abnormalityصورة بتوضح الـ abnormal بالـ
+
+524
+00:36:55,370 --> 00:37:01,870
+head double head يعني
+
+525
+00:37:01,870 --> 00:37:04,630
+حاجة مثل الـ cytoplasmic droplet بين head بين head
+
+526
+00:37:04,630 --> 00:37:08,850
+في هنا أشكال في ال mid piece و هنا أشكال في ال
+
+527
+00:37:08,850 --> 00:37:14,390
+tail طبعا أنا ما بميل أن أحفظ الأشكال ولكن أميل أن
+
+528
+00:37:14,390 --> 00:37:19,090
+يكون في عندي صورة كاملة لكل ال abnormal form or
+
+529
+00:37:19,090 --> 00:37:22,830
+morphology موجودة أمام ال technician علشان يقدر
+
+530
+00:37:23,160 --> 00:37:30,000
+يصنف شكل آخر بوضّحلي الـ abnormal form الممكن أنا
+
+531
+00:37:30,000 --> 00:37:33,140
+ك recognition ألجيها تحت ال microscope أشكال اللي
+
+532
+00:37:33,140 --> 00:37:36,060
+علاقة بال head defect أشكال اللي علاقة بال mid
+
+533
+00:37:36,060 --> 00:37:40,760
+piece or neck defect أشكال اللي علاقة بال tail
+
+534
+00:37:40,760 --> 00:37:45,520
+defect يعني على سبيل عملي و اللي أنا شوفته شوفت ال
+
+535
+00:37:45,520 --> 00:37:51,320
+megalo ال large head شوفت ال pin headشوفت الـ neck
+
+536
+00:37:51,320 --> 00:37:54,740
+بتكون شبه مكسورة زي الرقم اتنين هذه شوفت ال
+
+537
+00:37:54,740 --> 00:38:01,200
+droplet cytoplasm حوالين ال mid piece شوفت ال thin
+
+538
+00:38:01,200 --> 00:38:07,920
+mid piece شوفت ال cloid tail شوفت ال pentail ايضا
+
+539
+00:38:07,920 --> 00:38:11,580
+شوفت ال terminal cloid tail بهذا الشكل يعني في
+
+540
+00:38:11,580 --> 00:38:14,960
+أشكال مختلفة من ال abnormal morphology اللي ممكن
+
+541
+00:38:14,960 --> 00:38:20,650
+انت تشوفها تحت ال microscopeمصطلح له علاقة بال
+
+542
+00:38:20,650 --> 00:38:25,670
+sperm viability وبعض الأحيان بيطلب عليه sperm
+
+543
+00:38:25,670 --> 00:38:30,130
+viability يعني بمعنى آخر حيوية ال sperm هل ال
+
+544
+00:38:30,130 --> 00:38:34,630
+sperm حي أم ميت ال percentage of life ended sperm
+
+545
+00:38:34,630 --> 00:38:38,470
+in the sample and it's indicative of abnormalities
+
+546
+00:38:38,470 --> 00:38:42,850
+in any of the genital organs لما أقوم أن أعمل ال
+
+547
+00:38:42,850 --> 00:38:46,550
+viability test أو ال viability test هد بتعطيني
+
+548
+00:38:46,550 --> 00:38:49,430
+indication جداش في عندك sperm حيكداش في عندي الـ
+
+549
+00:38:49,430 --> 00:38:52,970
+sperm ميت و بتعطيني indication على وجود
+
+550
+00:38:52,970 --> 00:38:56,610
+abnormality في الـ genital organ أو لا طب كيف أنا
+
+551
+00:38:56,610 --> 00:39:01,610
+ممكن أحللها؟ ال analysis of sperm vitality is
+
+552
+00:39:01,610 --> 00:39:04,470
+based on the integrity of the sperm cell membrane
+
+553
+00:39:04,470 --> 00:39:07,730
+هذا ال principle يعني ال vitality test على شو
+
+554
+00:39:07,730 --> 00:39:11,630
+بتعتمد؟ تعتمد على ال integrity تبع ال sperm cell
+
+555
+00:39:11,630 --> 00:39:15,170
+membrane هل في عندي integrity بشكل معقول صحيح؟ هل
+
+556
+00:39:15,170 --> 00:39:20,300
+في عملوcontrolling لـ cell membrane على ما يدخل و
+
+557
+00:39:20,300 --> 00:39:24,760
+ما يخرج من خلية الحيوان المنوي بالشكل المطلوب و لا
+
+558
+00:39:24,760 --> 00:39:27,940
+لأ ممكن انا اعملها evaluation لـ viability
+
+559
+00:39:27,940 --> 00:39:32,720
+باستخدام Iosin-Nigrosin stain او باستخدام الـ hypo
+
+560
+00:39:32,720 --> 00:39:40,550
+osmotic swelling test تلت فحصين مهمين جداbiatility
+
+561
+00:39:40,550 --> 00:39:44,590
+is affected by number of variables such as
+
+562
+00:39:44,590 --> 00:39:47,390
+abnormal spermatogenesis and vascular and
+
+563
+00:39:47,390 --> 00:39:51,710
+prostatic fluid تلت عوامل بأثروا على حيوية ال
+
+564
+00:39:51,710 --> 00:39:55,390
+sperm أول حاجة ال abnormality في spermatogenesis
+
+565
+00:39:55,390 --> 00:39:58,750
+الشغل تاني ع ال abnormal في ال vascular ال
+
+566
+00:39:58,750 --> 00:40:02,310
+vascular أو ال prostatic fluid ال principle ببساطة
+
+567
+00:40:02,310 --> 00:40:06,750
+جدا أن أنا بصبغ ال sperm بصبغة ال sperm إذا كان
+
+568
+00:40:06,750 --> 00:40:10,290
+ميتالـ Integrity تبع الـ cell membrane بتكون
+
+569
+00:40:10,290 --> 00:40:15,310
+defect فبتسنح بدخول الصبغة إذا اللي كان ال sperm
+
+570
+00:40:15,310 --> 00:40:18,910
+live ال Integrity بتكون سليمة فتمنأ دخول الصبغة
+
+571
+00:40:18,910 --> 00:40:23,930
+فبالتالي بشوف أنا ال sperm in live cell membrane
+
+572
+00:40:23,930 --> 00:40:27,790
+remain intact and therefore exclude the dive from
+
+573
+00:40:27,790 --> 00:40:32,990
+penetrating بمعنى آخر إن إذا كان الحيوان المنوي حي
+
+574
+00:40:32,990 --> 00:40:39,850
+يبقى بلونه الطبيعي pale colorفاتح أما إذا كان الـ
+
+575
+00:40:39,850 --> 00:40:44,110
+sperm dead بياخد صبغة النجروسين أعفوا لل أيوزين أو
+
+576
+00:40:44,110 --> 00:40:47,570
+النجروسين و في الغالب صبغة ال أيوزين بتكون pink
+
+577
+00:40:47,570 --> 00:40:50,070
+color فبياخد اللون ال pink و هنشوفها كمان شوية
+
+578
+00:40:50,070 --> 00:40:56,090
+بصورة متى تستخدم و يجرى فحص ال viability عشان كده
+
+579
+00:40:56,090 --> 00:41:01,110
+بقولك ليس جميع المراكز تقوم بهذه الفرصات ككل تهتم
+
+580
+00:41:01,110 --> 00:41:04,110
+بال concentration و ال motility و ال volume بينما
+
+581
+00:41:04,110 --> 00:41:09,260
+ال viability test يتم إجراءهاإذا كان عدد الـ sperm
+
+582
+00:41:09,260 --> 00:41:13,320
+الـ motility أو ك percentage أقل من 10% يعني لما
+
+583
+00:41:13,320 --> 00:41:17,200
+أنا طالع أتقرر و ألاجى عندى ال motility total
+
+584
+00:41:17,200 --> 00:41:21,400
+motile أقل من 10% المفروض أعمل viability test لأنه
+
+585
+00:41:21,400 --> 00:41:25,500
+قد يكون ال sperm صحيح immotile ولكنه live فبالتالي
+
+586
+00:41:25,500 --> 00:41:30,500
+يمكن استخدامه في الحقن المجهري مابروحش أخد
+
+587
+00:41:30,500 --> 00:41:35,740
+testicular biopsy خزعة من ال testesطبعاً هذه
+
+588
+00:41:35,740 --> 00:41:40,040
+الصورة بتوضح الكلام اللي أنا قلته Hi في عندى صبغت
+
+589
+00:41:40,040 --> 00:41:44,080
+بال أيوزين الدد sperm أخد اللون ال pink في منطقة
+
+590
+00:41:44,080 --> 00:41:46,840
+ال head لأن ال integrity تبعت ال cell membrane
+
+591
+00:41:46,840 --> 00:41:51,760
+defect فسمحت بدخول الصبغة أما ال pale color أو ال
+
+592
+00:41:51,760 --> 00:41:55,880
+white color هو عبارة عن ال life sperm فبالتالي ما
+
+593
+00:41:55,880 --> 00:41:58,280
+أخد الصبغة لأن ال integrity تبعت ال cell membrane
+
+594
+00:41:58,280 --> 00:42:02,460
+كما هي فمنعت دخول الصبغة أو إن دخلت الصبغة عملت ال
+
+595
+00:42:02,460 --> 00:42:07,430
+exclusionطبعا هذه معظم النقاط اللي أنا بتتكلم عنها
+
+596
+00:42:07,430 --> 00:42:11,450
+في محاضرة اليوم، نرجو أن نكمل في المحاضرة القادمة
+
+597
+00:42:11,450 --> 00:42:13,950
+إن شاء الله، دوم توم في حفظ الله
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/kSV23vKKJRo_raw.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/kSV23vKKJRo_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..68635a8c664d743cb405747ee0df8abf50efb76d
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/kSV23vKKJRo_raw.srt
@@ -0,0 +1,2404 @@
+1
+00:00:00,840 --> 00:00:04,860
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:04,860 --> 00:00:10,460
+المرسلين سيدنا محمد وعلى آله وصحبه أجمعين طلابنا
+
+3
+00:00:10,460 --> 00:00:14,600
+الأعزاء نرجو من الله الكريم أن تكونوا جميعا بخير
+
+4
+00:00:14,600 --> 00:00:19,980
+وبصحة جيدة استكمالا لما بدأنا فيه من مواضيع متعلقة
+
+5
+00:00:19,980 --> 00:00:25,240
+بالحقن المجهري أساليبه وأنواعهوطرقه تحدثنا في
+
+6
+00:00:25,240 --> 00:00:28,340
+المحاضرات السابقة عن ال spermogenesis و ال
+
+7
+00:00:28,340 --> 00:00:32,600
+oogenesis تحدثنا عن الخطوات التي تمور بها ال
+
+8
+00:00:32,600 --> 00:00:36,720
+spermocyte من لحظة التصنيع حتى لحظة ال ejaculation
+
+9
+00:00:36,720 --> 00:00:40,980
+ثم مرورا بال reproductive system الخاص بالفيميل
+
+10
+00:00:40,980 --> 00:00:44,980
+لحظة ال intercourse من أجل ال fertilization ثم
+
+11
+00:00:44,980 --> 00:00:48,800
+تحدثنا عن ال oogenesis and الفيميل و كيف يحدث
+
+12
+00:00:48,800 --> 00:00:53,360
+عملية reduction في ال oocyte countتحت مصطلح
+
+13
+00:00:53,360 --> 00:00:59,920
+atresia وصولا إلى سن الرشد ثم مرورا بمراحل الدورة
+
+14
+00:00:59,920 --> 00:01:04,140
+الشهرية menstrual cycle التي تحدث عند السيدة وكام
+
+15
+00:01:04,140 --> 00:01:09,020
+بوايضة يتنفقدانها تحت مصطلح atresia بشكل شهري ماهي
+
+16
+00:01:09,020 --> 00:01:13,720
+الهرمونات التي تساهم في إنتاج وانداج البوايضة؟ متى
+
+17
+00:01:13,720 --> 00:01:17,280
+يحدث التلقيح؟ وأين يحدث التلقيح؟ ماهو الكوربس
+
+18
+00:01:17,280 --> 00:01:21,690
+اليوتيام؟ ماهو الكوربس البيكان؟متى يتكون ومتى
+
+19
+00:01:21,690 --> 00:01:27,290
+يندثر أو يتكسّر اليوم سننتقل إلى مربع جديد له
+
+20
+00:01:27,290 --> 00:01:31,990
+علاقة بالميل بشكل أساسي تحت مصطلح sperm assessment
+
+21
+00:01:31,990 --> 00:01:37,170
+processing and selection وذلك لأن عملية ال
+
+22
+00:01:37,170 --> 00:01:41,010
+fertilization أو عملية الإجزي الـ Intracytoplasmic
+
+23
+00:01:41,010 --> 00:01:44,810
+sperm injection تحتاج إلى single sperm لكي تتم
+
+24
+00:01:44,810 --> 00:01:50,790
+بشكل أبيعي وبشكل سليمإضافة إلى single oocyte يجب
+
+25
+00:01:50,790 --> 00:01:56,130
+أن تكون mature فبالتالي الإجزة عملية تحتاج إلى two
+
+26
+00:01:56,130 --> 00:02:00,050
+جميط Male جميط هي single sperm mature و Female
+
+27
+00:02:00,050 --> 00:02:04,390
+جميط هي oocyte mature ولكي تحدث عملية ال
+
+28
+00:02:04,390 --> 00:02:07,850
+fertilization يجب أن يحدث عملية treatment أو
+
+29
+00:02:07,850 --> 00:02:12,110
+processing للسمين ال fluid أو للسمين ال sample أو
+
+30
+00:02:12,110 --> 00:02:16,070
+للسمين ال sample علشان أقدر أن أحصل على only one
+
+31
+00:02:16,070 --> 00:02:16,910
+single sperm
+
+32
+00:02:21,890 --> 00:02:26,780
+العملية تحتاج إلى عمليةEvaluation للـ Seminal
+
+33
+00:02:26,780 --> 00:02:30,620
+Fluid تحتاج إلى عملية assessment للـ Seminal Fluid
+
+34
+00:02:30,620 --> 00:02:35,380
+تحتاج إنك تكتب تقرير صحيح وسليم المشكلة إن معظم ال
+
+35
+00:02:35,380 --> 00:02:38,040
+routine lab ما بتقوم بعمل ال Seminal Fluid
+
+36
+00:02:38,040 --> 00:02:41,700
+Analysis أو الـ Semin Analysis باستثناء المرايات
+
+37
+00:02:41,700 --> 00:02:45,480
+والمختبرات المتخصصة التي لها علاقة بال Andrology
+
+38
+00:02:45,480 --> 00:02:50,100
+أو التي لها علاقة باطفال الحقن المجاني معظم الطلاب
+
+39
+00:02:50,100 --> 00:02:56,090
+يكون عندهم افتقار فيهذا الشق بسبب عدم التمرس و عدم
+
+40
+00:02:56,090 --> 00:03:00,630
+التدريب و التدرب عليه لذلك يجب علينا أن نفرض جزء
+
+41
+00:03:00,630 --> 00:03:05,890
+من هذه المحاضرات تتعلق بـ Seminal Process أو
+
+42
+00:03:05,890 --> 00:03:10,130
+Seminal Analysis لما أقول أنا عندي infertility
+
+43
+00:03:10,130 --> 00:03:14,190
+Male infertile يعني غير قادر أو عنده مشكلة خليني
+
+44
+00:03:14,190 --> 00:03:18,490
+أسميها في الحصول على طفللما أقول عندي مال استرال
+
+45
+00:03:18,490 --> 00:03:22,850
+يعني ذكر عقيم لا يستطيع أن ينجب سواء كان بالطريقة
+
+46
+00:03:22,850 --> 00:03:27,710
+الطبيعية أو بالطريقة الصناعية من خلال الحقن
+
+47
+00:03:27,710 --> 00:03:34,930
+المجاني ومع ذلك صنف ال WHO بعض الذكور على أنه
+
+48
+00:03:34,930 --> 00:03:40,540
+Proven Fertilefertile, subfertile, sterile طبعا
+
+49
+00:03:40,540 --> 00:03:44,980
+هذا يعتمد على المقدر على الإنجاب بشكل طبيعي المقدر
+
+50
+00:03:44,980 --> 00:03:48,320
+على الإنجاب بعد التلقيح الصناعي وكيف تكون ال semen
+
+51
+00:03:48,320 --> 00:03:53,660
+parameter فبالتالي وجدوا أن ال seminal analysis أو
+
+52
+00:03:53,660 --> 00:03:59,600
+تحليل السائل عند الذكور هو عبارة عن أول فحص يطلب
+
+53
+00:03:59,600 --> 00:04:04,930
+من أجل تشخيص القدرة الإنجابية عند الرجلWe can
+
+54
+00:04:04,930 --> 00:04:08,330
+evaluate the fertility status for any male person
+
+55
+00:04:08,330 --> 00:04:12,890
+by using seminal analysis as a fair system بناء
+
+56
+00:04:12,890 --> 00:04:15,930
+على ال seminal analysis ممكن أن أحصل على بعض ال
+
+57
+00:04:15,930 --> 00:04:20,490
+information التي تتعلق بالـ functional of sperm
+
+58
+00:04:20,490 --> 00:04:23,730
+production by testis هل ال testis بتفرزلي و
+
+59
+00:04:23,730 --> 00:04:29,390
+بتنتجلي sperm بشكل كافي وبالكمية المطلوبة وبالحجم
+
+60
+00:04:29,390 --> 00:04:34,450
+المطلوب وبالعدد المطلوبأضف إلى ذلك الـ potency of
+
+61
+00:04:34,450 --> 00:04:39,690
+genital tract كيف هي قدرة الـ genital tract في نقل
+
+62
+00:04:39,690 --> 00:04:43,090
+و في إخراج الـ seminal fluid هل تمشي و تسير بشكل
+
+63
+00:04:43,090 --> 00:04:47,790
+طبيعي أم هناك بعض المشاكل؟ أيضًا بيعطيني picture و
+
+64
+00:04:47,790 --> 00:04:52,410
+photo كاملة عن الـ secretory activity of the all
+
+65
+00:04:52,410 --> 00:04:54,370
+accessory gland الـ accessory gland زي الـ
+
+66
+00:04:54,370 --> 00:04:58,110
+prostatic gland كيف طبيعة عمل؟ هل تعمل بشكل سليم؟
+
+67
+00:04:58,280 --> 00:05:01,420
+تعمل بشكل دقيق، في عندها مشكلة، في عندى
+
+68
+00:05:01,420 --> 00:05:03,660
+deficiencies في الـ activity الخاصة فيها أمهية
+
+69
+00:05:03,660 --> 00:05:06,580
+normal في الـ normal status The information
+
+70
+00:05:06,580 --> 00:05:11,720
+contributes to the effective establishment of
+
+71
+00:05:11,720 --> 00:05:15,200
+individual diagnoses and serve as the essential
+
+72
+00:05:15,200 --> 00:05:18,460
+basic investigation of male factors on the
+
+73
+00:05:18,460 --> 00:05:22,240
+infertile couple فبالتاني، الـ seminal fluid يعتبر
+
+74
+00:05:22,240 --> 00:05:26,180
+أول فحص يطلب في تشخيص الحالة الإنجابية أو القدرة
+
+75
+00:05:26,180 --> 00:05:30,950
+الإنجابية عند اللأنه هيعطيني صورة عامة إلى حد ما
+
+76
+00:05:30,950 --> 00:05:37,230
+عن الوضع الحالي الذي يتمتع بيه الذاكرة بالنسبة لل
+
+77
+00:05:37,230 --> 00:05:40,810
+Basic Seminal Analysis بيلعب دور مهم جدا في الـ
+
+78
+00:05:40,810 --> 00:05:43,350
+Central .. الـ Central role في ال diagnostic of
+
+79
+00:05:43,350 --> 00:05:46,990
+male infertility في ال making significant
+
+80
+00:05:46,990 --> 00:05:49,750
+contribution to the diagnosis process in
+
+81
+00:05:49,750 --> 00:05:54,390
+andrology، gynecologyunclinical urology في تلاتة
+
+82
+00:05:54,390 --> 00:05:57,970
+unit هذه ال unit الخاص بالclinical urology ال unit
+
+83
+00:05:57,970 --> 00:06:00,150
+الخاص بالandrology ال unit الخاص بالclinical ال
+
+84
+00:06:00,150 --> 00:06:04,810
+clinic أو ال unit الخاص بكينيكولوجيا تولدت تلاتة
+
+85
+00:06:04,810 --> 00:06:08,710
+unit بيهتموا بال seminal analysis بالدرجة الأولى
+
+86
+00:06:08,710 --> 00:06:14,470
+as basic analysis or basic test في طبعا اختلاف ما
+
+87
+00:06:14,470 --> 00:06:17,650
+بين العلماء فعلى سبيل المثال في الأيام الحالية
+
+88
+00:06:17,650 --> 00:06:21,680
+الدراسات حكت أنهExamination include the analysis
+
+89
+00:06:21,680 --> 00:06:26,000
+of certain established seminal parameters can
+
+90
+00:06:26,000 --> 00:06:29,020
+provide key information about the quality of
+
+91
+00:06:29,020 --> 00:06:33,880
+patient's semen and functional of sperm بمعنى آخر
+
+92
+00:06:33,880 --> 00:06:37,620
+إن أنا بمجرد ما أحصل على تقرير له علاقة بالـ
+
+93
+00:06:37,620 --> 00:06:41,760
+Seminal Analysis بشكل صحيح ومضبوط أستطيع أن أحصل
+
+94
+00:06:41,760 --> 00:06:45,800
+على صورة مبدئية عن الوضع الصحي والإنجابي الخاص
+
+95
+00:06:45,800 --> 00:06:49,910
+بالمرض وبما على ليه بقدر أشخص الحالة المرضيةوبقدر
+
+96
+00:06:49,910 --> 00:06:53,610
+أحدد في ببعض طبيعة الفحوصات اللي أنا ممكن أطلبها
+
+97
+00:06:53,610 --> 00:06:57,990
+في المستقبل علشان يعملي correct or true diagnostic
+
+98
+00:06:57,990 --> 00:07:04,310
+or حاجة بنسميها تشخيص سليم، تشخيص صحيح 100% this
+
+99
+00:07:04,310 --> 00:07:06,850
+information can help to determine reproductive
+
+100
+00:07:06,850 --> 00:07:11,630
+capacity of male فبالتالي ممكن أنا من فقط ال
+
+101
+00:07:11,630 --> 00:07:14,910
+seminal fluid أو ال seminal analysis أتعرف على
+
+102
+00:07:14,910 --> 00:07:19,110
+الحالة الإنجابيةالـ WHO وهي اختصار للـ World
+
+103
+00:07:19,110 --> 00:07:23,650
+Healthy Organization عملت دراسات وعملت reference
+
+104
+00:07:23,650 --> 00:07:28,090
+value للـ seminal fluid بمعنى قيم متعلقة بالـ
+
+105
+00:07:28,090 --> 00:07:32,010
+Fertile Men أو Fertile Males ما هي الـ reference؟
+
+106
+00:07:32,010 --> 00:07:34,530
+يعني كم يجب أن تكون الـ utility كم يجب أن تكون
+
+107
+00:07:34,530 --> 00:07:36,790
+الحركة؟ كم يجب أن تكون العدد؟ كم يجب أن تكون ال
+
+108
+00:07:36,790 --> 00:07:39,430
+morphology؟ كم يجب أن تكون ال volume؟ كم يجب أن
+
+109
+00:07:39,430 --> 00:07:44,580
+تكون ال pH؟ هذا نسميها reference value أيضاووجدوا
+
+110
+00:07:44,580 --> 00:07:49,300
+وصنعوا وكوّنوا وحضروا multi-step for manual
+
+111
+00:07:49,300 --> 00:07:54,280
+seminal analysis كنت ك تكنيشن ك أندرولوجيست كيف
+
+112
+00:07:54,280 --> 00:07:57,580
+تستطيع عمل تحليل السائل ما هي الخطوات المتبعة من
+
+113
+00:07:57,580 --> 00:08:03,560
+لحظة استلام العينة حتى كتابة التقرير لكي نجمل هذه
+
+114
+00:08:03,560 --> 00:08:08,760
+النقاط و هذه الخطوات قسموها إلى pre-analytical وهي
+
+115
+00:08:08,760 --> 00:08:13,110
+خطواتنا قبل الفحصanalytical خطوات متعلقة بالفحص
+
+116
+00:08:13,110 --> 00:08:18,130
+post-analytical خطوات ما بعد الفحص وهي التي تشمل
+
+117
+00:08:18,130 --> 00:08:22,690
+في كتابة التقرير وتفسير النتائج فبالتالي الـ
+
+118
+00:08:22,690 --> 00:08:25,690
+Seminal بالوضع الطبيعي هو عبارة عن heterogeneous
+
+119
+00:08:25,690 --> 00:08:31,530
+fluid بتكون من عدة مكونات مختلفة هذه المكونات قد
+
+120
+00:08:31,530 --> 00:08:36,650
+تتأثر بعوامل داخلية لها علاقة بالبيئة الداخلية
+
+121
+00:08:36,650 --> 00:08:41,870
+لجسد الإنسان أو جسد الذكروطبيعة غذائه وعوامل
+
+122
+00:08:41,870 --> 00:08:44,450
+خارجية اللي بتسميها environment factor أو
+
+123
+00:08:44,450 --> 00:08:48,870
+extrinsic factor من أشهر العوامل اللتي قد تؤثر على
+
+124
+00:08:48,870 --> 00:08:52,650
+ال infertility أو على خلّيني أسميها بشكل أوضح على
+
+125
+00:08:52,650 --> 00:08:57,150
+ال seminal analysis ال infection هل وجود infection
+
+126
+00:08:57,150 --> 00:09:02,130
+في القنوات الناقلة أو في المصنع ال accessory gland
+
+127
+00:09:02,130 --> 00:09:06,770
+function كيف وظيفة هذه الغدد المساعد هل تقوم
+
+128
+00:09:06,770 --> 00:09:11,330
+بالوظيفة المطلوبة ولا فيها انها inhibitionالـ
+
+129
+00:09:11,330 --> 00:09:14,870
+period of sexual absence الفترة الإمتناء عن الـ
+
+130
+00:09:14,870 --> 00:09:17,570
+ejaculation تلت أيام ولا أربع أيام ولا خمس أيام
+
+131
+00:09:17,570 --> 00:09:21,450
+خدوا بالك الفترة هذه مهمة جدا لأنه بناء عليها أنا
+
+132
+00:09:21,450 --> 00:09:26,410
+بقدر أقيم بشكل سليم وبشكل صحيح ال value اللي بتطلع
+
+133
+00:09:26,410 --> 00:09:31,090
+بعد تحليل السائل أيضا من العوامل التي تؤثر
+
+134
+00:09:31,090 --> 00:09:35,570
+anatomical hormonalGenetic Life Style Factors All
+
+135
+00:09:35,570 --> 00:09:39,450
+of these factors can contribute to male fertility
+
+136
+00:09:39,450 --> 00:09:42,490
+خدوا بالك الهرمون عامل مهم زي ما شوفنا في الشبطة
+
+137
+00:09:42,490 --> 00:09:45,910
+الرقم اتنين هو المسؤول عن إنتاج الـ spermatocyte
+
+138
+00:09:45,910 --> 00:09:50,450
+Life Style زي ال smoking و الكفين و ال stress عندك
+
+139
+00:09:50,450 --> 00:09:53,230
+ال anatomical هنتكلم عنها زي ما اتكلمنا عنها عند
+
+140
+00:09:53,230 --> 00:09:58,650
+ال female و genetic بعض المشاكل الوراثية قد تؤدي
+
+141
+00:09:58,650 --> 00:10:05,250
+إلى ال infertility عند ال maleطبعاً هذا شكل بوضّح
+
+142
+00:10:05,250 --> 00:10:08,910
+و جدول بوضّح الـ Normal Value للـ Cement Parameter
+
+143
+00:10:08,910 --> 00:10:12,710
+الـ Liquefaction Time و هو وقت الإسالة تلاتين
+
+144
+00:10:12,710 --> 00:10:16,790
+minutes كحد أقصى الـ Ejaculation Fold Volume و هو
+
+145
+00:10:16,790 --> 00:10:20,910
+الحجم المقضوف لازم يكون أقل أقفل أكبر من أو يساوي
+
+146
+00:10:20,910 --> 00:10:26,050
+1.5 ملي لتر عند الـ Normal من الفسكوسة اللزوجة
+
+147
+00:10:26,050 --> 00:10:30,330
+لازم تعطيني Line خطب نسميها و هنعرف إيش يعني Line
+
+148
+00:10:31,010 --> 00:10:35,510
+طوله أقل من أو يسوى 2 cm هي ال line اللى بتخرج من
+
+149
+00:10:35,510 --> 00:10:38,770
+ال pipet ال plastic pipet اللى هنتكلم عنها ال
+
+150
+00:10:38,770 --> 00:10:43,030
+total sperm count يجب أن يكون أكبر من أو يسوى 39
+
+151
+00:10:43,030 --> 00:10:46,990
+مليون ال sperm concentration لازم يكون أكبر من أو
+
+152
+00:10:46,990 --> 00:10:51,150
+يسوى 15 مليون ال total motility لازم يكون أكبر من
+
+153
+00:10:51,150 --> 00:10:58,020
+أو تسوى 40%أكبر من أو تسوى 32% الـ viatility أو
+
+154
+00:10:58,020 --> 00:11:01,220
+الـ life sperm لازم العينة تحتوي على أكثر من أو
+
+155
+00:11:01,220 --> 00:11:06,120
+تسوى 58% أما بالنسبة للـ monormal form الشكل
+
+156
+00:11:06,120 --> 00:11:10,480
+الطبيعي للـ sperm يجب أن تحتوي العينة على أكثر من
+
+157
+00:11:10,480 --> 00:11:14,960
+40% من ال spermatocyte عفوا أكثر من 4% من ال
+
+158
+00:11:14,960 --> 00:11:19,500
+spermatocyte تكون normal form فبنال كل هذه ال
+
+159
+00:11:19,500 --> 00:11:24,310
+parameter مهمة هي في المنطق والمعقول مهمةولكن أكثر
+
+160
+00:11:24,310 --> 00:11:28,790
+ما نهتم فيه إيجا ال volume و ال sperm
+
+161
+00:11:28,790 --> 00:11:32,250
+concentration و ال total motility و المورفوليجي بس
+
+162
+00:11:32,250 --> 00:11:37,250
+في ال X المورفوليجي نسقط عنه أهم شيء ال motility و
+
+163
+00:11:37,250 --> 00:11:41,330
+ال concentration
+
+164
+00:11:41,330 --> 00:11:46,930
+صورة توضح ال step اللي احنا قسمناها pre analytical
+
+165
+00:11:46,930 --> 00:11:50,650
+و analytical و post analyticalأول حاجة في عندي الـ
+
+166
+00:11:50,650 --> 00:11:55,410
+Sample Collection وهي مسئولية المريض بحد أول
+
+167
+00:11:55,410 --> 00:11:59,850
+وبدرجة أولى الـ Technician وظيفته الأساسية يعطي
+
+168
+00:11:59,850 --> 00:12:04,950
+الـ Container Stripe ويقوله ويحكي له أهم التعليمات
+
+169
+00:12:04,950 --> 00:12:09,470
+اللازم أثناء جمع العينة تعطيه بعض التوصيات من
+
+170
+00:12:09,470 --> 00:12:14,740
+خلالها بيقدر يوصل العينة بشكل سليم 100%ممكن تجمع
+
+171
+00:12:14,740 --> 00:12:17,980
+الأينا في المكان، مكان إجراء الفحص أو في البيت بس
+
+172
+00:12:17,980 --> 00:12:21,620
+بشرط منطقة اللي هو فترة زمان يا بابينا وصولها
+
+173
+00:12:21,620 --> 00:12:25,620
+لمختبر وجامعة في البيت لا تقزيد عن نص ساعة أما
+
+174
+00:12:25,620 --> 00:12:29,320
+بالنسبة إلى عملية الـ Analysis وهي الـ Analytical
+
+175
+00:12:29,320 --> 00:12:33,820
+تقسم إلى قسمين Macro و Micro الـ Macro أي شيء أنا
+
+176
+00:12:33,820 --> 00:12:38,900
+بشوفه بالعين المجردة زي Liquefication Sample Age
+
+177
+00:12:38,900 --> 00:12:43,180
+يعني جمعت من ساعة، من ساعة و نصالـ Appearance، الـ
+
+178
+00:12:43,180 --> 00:12:47,440
+Volume، الـ Viscosity و الـ pH هذه تقسم macro أما
+
+179
+00:12:47,440 --> 00:12:50,820
+ال micro زي ال motility، ال concentration، ال
+
+180
+00:12:50,820 --> 00:12:56,020
+morphology، ال agglutination في بعض المصطلحات وبعض
+
+181
+00:12:56,020 --> 00:12:59,680
+الأطباء خليني أسميها وبعض المصطلحات الطبية التي
+
+182
+00:12:59,680 --> 00:13:05,760
+تستخدم تطلب من قبل أطباء كفحوصات مساعدة ولكنها
+
+183
+00:13:05,760 --> 00:13:11,840
+أساسية تحت عنوانHell paying test أو خلّيني أسميها
+
+184
+00:13:11,840 --> 00:13:15,140
+اوكي من أشهرها ال fractose نقيص نسبة ال fractose
+
+185
+00:13:15,140 --> 00:13:18,900
+في السمن الفلوينت و ال sperm و ال biatility جداش
+
+186
+00:13:18,900 --> 00:13:23,940
+عدد ال life sperm مهم جدا خصوصا أثناء عملية الإلاج
+
+187
+00:13:23,940 --> 00:13:30,020
+هذه أشهر المصطلحات اللي احنا هنواجهها خلال عملية
+
+188
+00:13:30,020 --> 00:13:35,740
+ال seminal analysisطبعاً عملية جمع العينة بشكل
+
+189
+00:13:35,740 --> 00:13:39,960
+أساسي تعتبر هي الـ critical step بمعنى آخر لو جمعت
+
+190
+00:13:39,960 --> 00:13:43,660
+العينة بطريقة غير سليمة فالنتيجة تلقائيا غير سليمة
+
+191
+00:13:43,660 --> 00:13:47,540
+وغير صحيحة فيجب أن تجمع العينة بطريقة سليمة طريقة
+
+192
+00:13:47,540 --> 00:13:52,640
+صحيحة 100% لكي تؤدي إلى إنتاج نتيجة سليمة وللعملية
+
+193
+00:13:52,640 --> 00:13:57,100
+الـ sample collection مسئولية المريض بحد أقصى وبحد
+
+194
+00:13:57,100 --> 00:14:01,400
+ودرجة أولى ولكن if liquification does not occur
+
+195
+00:14:01,400 --> 00:14:04,360
+probablyThe physical and chemical properties of
+
+196
+00:14:04,360 --> 00:14:10,340
+the seminal may be wrong or have a problem بمعنى
+
+197
+00:14:10,340 --> 00:14:14,300
+آخر، العينة الملطسة للمختبر لازم يصلها إسالة بشكل
+
+198
+00:14:14,300 --> 00:14:18,220
+سليم وصحيح إذا صارلها إسالة بشكل غير سليم وغير
+
+199
+00:14:18,220 --> 00:14:22,720
+صحيح، النتيجة تعتبر غير دقيقة من أهم الـ Adjacent
+
+200
+00:14:22,720 --> 00:14:25,340
+Test أو الـ Helping Test اللي احنا حكينا فيها الـ
+
+201
+00:14:25,340 --> 00:14:28,820
+Viatilityالـ lycoside الـ concentration of
+
+202
+00:14:28,820 --> 00:14:33,560
+fructose الـ concentration of fructose for example
+
+203
+00:14:33,560 --> 00:14:38,080
+هذه الـ most common الفحوصات التي يمكن أن تستخدم و
+
+204
+00:14:38,080 --> 00:14:42,940
+تطلب من قبل الطبيب للمساعدة في تشخص المرض سامبل
+
+205
+00:14:42,940 --> 00:14:47,120
+كولكشن تجمع العينة في container استلاءة استرايه
+
+206
+00:14:47,120 --> 00:14:50,240
+container with wide mouth مايعني wide mouth؟ يعني
+
+207
+00:14:50,240 --> 00:14:54,200
+فتحة ال container تكون واسعة ليس منطق تجمع في ال
+
+208
+00:14:54,200 --> 00:14:58,460
+test tube على سبيل المثاللازم تجمع في cup يشبه ال
+
+209
+00:14:58,460 --> 00:15:02,820
+urine cup ولكن استرالي دايما بكون cover red color
+
+210
+00:15:02,820 --> 00:15:07,620
+زي على سبيل المثال ال cup اللي يستخدم فيه ال urine
+
+211
+00:15:07,620 --> 00:15:15,560
+culture طبعا ممنوع انا ك technician لازم عليا انه
+
+212
+00:15:15,560 --> 00:15:20,080
+اقول للمريض انه يجب ان يمتنع عن جمع العين باستخدام
+
+213
+00:15:20,080 --> 00:15:24,200
+ال apricot او ال condom لان كلاهم في مواد قاتلة لل
+
+214
+00:15:24,200 --> 00:15:30,580
+sperm حاجة بتسميها spermSpermocidal agent تجمع
+
+215
+00:15:30,580 --> 00:15:33,600
+العينة بطريقة واحدة وأفضل الطرق على الإطلاق هي
+
+216
+00:15:33,600 --> 00:15:37,840
+طريقة ال master patient طريقة توتمت في مراكز
+
+217
+00:15:37,840 --> 00:15:42,740
+التلقيح الصيني العينة جميعها يجب أن تجمع في ال
+
+218
+00:15:42,740 --> 00:15:45,960
+container أي فقدر للعينة يجب أن يبلغ به ال
+
+219
+00:15:45,960 --> 00:15:49,560
+technician يعني بمعنى أخر المفروض يعمل ejaculation
+
+220
+00:15:49,560 --> 00:15:54,850
+لخمسة مل تم جمع أربعة مل إذا بكتب خمس أربعة ملخمسة
+
+221
+00:15:54,850 --> 00:15:58,970
+mil collected قسمين أربع mil received و one mil
+
+222
+00:15:58,970 --> 00:16:08,010
+مفقد ال time of collection مهم جدا لو أنا كمريد
+
+223
+00:16:08,010 --> 00:16:11,510
+جمعت العينة في المختبر لازم أبلغ التكنيشن بالوقت
+
+224
+00:16:11,510 --> 00:16:15,530
+اللي جمعت فيه العينة لو كمريد جمعت العينة في البيت
+
+225
+00:16:15,530 --> 00:16:18,930
+لازم أبلغ التكنيشن بالوقت اللي جمعت فيه العينة
+
+226
+00:16:18,930 --> 00:16:23,050
+سواء كان في البيتأو في المختبر عشان بناء عليه لازم
+
+227
+00:16:23,050 --> 00:16:28,130
+يحسب الـ liquification ال sample collection بمجرد
+
+228
+00:16:28,130 --> 00:16:30,550
+ما أحصل عليها لازم أكتب كل البيانات على ال
+
+229
+00:16:30,550 --> 00:16:34,390
+container و أدخلها في ال incubator على 37 درجة
+
+230
+00:16:34,390 --> 00:16:38,790
+موية من أجل ال liquification ثم أبدأ فيما بعد بال
+
+231
+00:16:38,790 --> 00:16:43,930
+macroscopic analysis اللي لازم يتم خلال فترة زمنية
+
+232
+00:16:43,930 --> 00:16:48,200
+من نصها على تلقى 60دقيقة خلال هذه الفترة الزمنية
+
+233
+00:16:48,200 --> 00:16:52,500
+لازم كل ال macroscopic examination أو analysis
+
+234
+00:16:52,500 --> 00:16:58,640
+تكون أنهيت منها بشكل كامل زي الviscosity زي ال pH
+
+235
+00:16:58,640 --> 00:17:04,000
+زي ال color زي ال volume وخلافه The most important
+
+236
+00:17:04,000 --> 00:17:06,980
+issue of the sample collection is the absent time
+
+237
+00:17:06,980 --> 00:17:10,880
+the number of days without ejaculation مهم جدا
+
+238
+00:17:10,880 --> 00:17:15,830
+بشكل كبير جدا أنهتجمع العينة بعد امتناع عن ال
+
+239
+00:17:15,830 --> 00:17:19,270
+ejaculation أو عن ال intercourse بفترة زمنية معينة
+
+240
+00:17:19,270 --> 00:17:24,570
+أقلها تلت أيام، أكثرها خمس أيام ولكن معظم المراكز
+
+241
+00:17:24,570 --> 00:17:27,410
+تستعمل أن يجب على المريض الامتناع عن ال
+
+242
+00:17:27,410 --> 00:17:31,430
+ejaculation أو ال intercourse تلت أيام بشكل أساسي
+
+243
+00:17:31,430 --> 00:17:34,970
+في اليوم التالت بيجمع العينة في نهاية اليوم التالت
+
+244
+00:17:34,970 --> 00:17:38,340
+أو بعض الاحيان بيقولك في بداية اليوم الرابعالمهم
+
+245
+00:17:38,340 --> 00:17:41,820
+يكون له تلات أيام ممتنة before sample collection
+
+246
+00:17:41,820 --> 00:17:44,840
+spermatozoa are stored in the epidermis until
+
+247
+00:17:44,840 --> 00:17:50,180
+ejaculation however, the epidermal storage is not
+
+248
+00:17:50,180 --> 00:17:53,200
+completely empty in the single ejaculation and the
+
+249
+00:17:53,200 --> 00:17:56,240
+remaining spermatozoa stay until the next
+
+250
+00:17:56,240 --> 00:18:00,560
+ejaculation كون على ثقة إن صحيح إن ال spermatozoa
+
+251
+00:18:00,560 --> 00:18:04,920
+تخزن في ال epidermis ولكن خلال ال ejaculationاللي
+
+252
+00:18:04,920 --> 00:18:08,860
+بيعطيها الـ 105 أو 3 أو 4 ميل ما بيطلع كل المخزون
+
+253
+00:18:08,860 --> 00:18:14,920
+جزء منه يبقى لـ Ejaculation التالية علشان كده مهم
+
+254
+00:18:14,920 --> 00:18:21,180
+جدا أكون هذه المعلومة في نص عيني ويبقى على دراية
+
+255
+00:18:21,180 --> 00:18:26,420
+فيها علشان أقدر أقيم بشكل سليم Ideal duration of
+
+256
+00:18:26,420 --> 00:18:32,120
+sexual absence2 to 3 days و لكن الكل متفق على تلت
+
+257
+00:18:32,120 --> 00:18:35,100
+أيام معظمهم متفق على تلت أيام يجب على المريض اللي
+
+258
+00:18:35,100 --> 00:18:39,460
+مدينة عنه ejaculation أو الintercourses تلت أيام
+
+259
+00:18:39,460 --> 00:18:45,320
+طيب لو أنا بدي أعمل تحليل آخر كقبيل طلب تحليل آخر
+
+260
+00:18:45,320 --> 00:18:50,100
+المريض يجمع العينة مباشرة ولا ينتظر فترة لازم
+
+261
+00:18:50,100 --> 00:18:55,060
+المريض ينتظر فترة أقلها سبوعين يعني التحليل الأول
+
+262
+00:18:55,060 --> 00:18:58,280
+كان في واحد عشرة التحليل التاني لازم يكون في أربع
+
+263
+00:18:58,280 --> 00:19:02,770
+تاشر عشرةيعني بمعنى أخر بين التحليل الأول والتاني
+
+264
+00:19:02,770 --> 00:19:08,870
+أسبوعين هي نقطة تجمع بنفس الطريقة هي نقطتين تجمع
+
+265
+00:19:08,870 --> 00:19:12,470
+بنفس ال absence of intercourse أو ال sexual
+
+266
+00:19:12,470 --> 00:19:15,110
+absence في المرة الأولى امتنع يومين في المرة
+
+267
+00:19:15,110 --> 00:19:17,490
+التانية لازم امتنع يومين في المرة الأولى امتنع
+
+268
+00:19:17,490 --> 00:19:20,670
+تلاتة في المرة التانية لازم امتنع تلت أيام علشان
+
+269
+00:19:20,670 --> 00:19:25,210
+يصير في عندي نوع من أنواع ال bias اتجنبهتجنب الـ
+
+270
+00:19:25,210 --> 00:19:28,730
+bias أو الـ interfere اللي ممكن تتصير ال interval
+
+271
+00:19:28,730 --> 00:19:31,350
+between separated C من ال analysis is generally
+
+272
+00:19:31,350 --> 00:19:36,070
+recommended to be two to four weeks ولكن الكل متفق
+
+273
+00:19:36,070 --> 00:19:40,190
+أنه أقل شي أسبوعين فبالتالي أسبوعين و إيام مينفع
+
+274
+00:19:40,190 --> 00:19:43,750
+معاك من أسبوعين لأربع أسبوع كمريل ولكن الكل متفق
+
+275
+00:19:43,750 --> 00:19:46,650
+زي ما هو متفق على تلت أيام sexual absence الكل
+
+276
+00:19:46,650 --> 00:19:51,490
+متفق على تلت أسبوعين ما بين العينة الأولى و العينة
+
+277
+00:19:51,490 --> 00:19:52,670
+التالية
+
+278
+00:19:54,630 --> 00:19:58,050
+نبدأ بأول نقطة إلى علاقة بالـ macroscopic
+
+279
+00:19:58,050 --> 00:20:00,970
+evaluation كيف يمكن تحديد الـ macroscopic
+
+280
+00:20:00,970 --> 00:20:03,970
+evaluation؟ بمعنى آخر، هل يمكن تحديد الـ
+
+281
+00:20:03,970 --> 00:20:07,770
+macroscopic evaluation؟ وما هي؟ أول test له علاقة
+
+282
+00:20:07,770 --> 00:20:10,970
+بالـ macroscopic الـ liquefication، وهي الإسالة
+
+283
+00:20:10,970 --> 00:20:17,850
+الإسالة هي تحول الـ seminal fluid من شكل الكتل إلى
+
+284
+00:20:17,850 --> 00:20:21,490
+شكل liquid من الشكل الـ semisolid إلى شكل الـ
+
+285
+00:20:21,490 --> 00:20:21,650
+liquid
+
+286
+00:20:26,220 --> 00:20:31,500
+الـ Semen بيخرج على شكل دفقات هي عبارة محاطة بكمية
+
+287
+00:20:31,500 --> 00:20:35,700
+من البروتين لتحميه من ال external environment أو
+
+288
+00:20:35,700 --> 00:20:40,040
+external factor بالإضافة إلى ال environment
+
+289
+00:20:40,040 --> 00:20:43,100
+المختلفة الموجودة في ال reproductive tract الخاصة
+
+290
+00:20:43,100 --> 00:20:47,320
+بالفيميل فبالتالي after ejaculation human semen
+
+291
+00:20:47,320 --> 00:20:51,600
+form lose gel-like coagulant in a few seconds by
+
+292
+00:20:51,600 --> 00:20:55,790
+cross-linking of seminal vesicle proteinلذن السمنة
+
+293
+00:20:55,790 --> 00:20:59,170
+الـ fluid بمجرد خروجه من جسم الإنسان بيتحول من
+
+294
+00:20:59,170 --> 00:21:02,430
+القوام الجيلاتيني الجلي إلى القوام السائل بفعل
+
+295
+00:21:02,430 --> 00:21:05,810
+إنزيمات وبروتينات موجودة في السمنة الـ fluid من
+
+296
+00:21:05,810 --> 00:21:11,450
+أشارها السينوكليين 1 و 2 و الفيبرينوكتين as
+
+297
+00:21:11,450 --> 00:21:17,170
+protein the formation of coagulant مهم جدا، ماهو
+
+298
+00:21:17,170 --> 00:21:20,150
+هدف الـ coagulant؟ ماهو هدف المادة الجيلاتينية
+
+299
+00:21:20,150 --> 00:21:26,370
+التي تحيط بالسمنة بال spermatozoaأو بـ sperm حكينا
+
+300
+00:21:26,370 --> 00:21:32,530
+أول شغلة بتعمل على تقليل معدل خروج السمن الفلود من
+
+301
+00:21:32,530 --> 00:21:36,150
+منطقة الفاجينة فهذا بيزيد من فرصة ال fertilization
+
+302
+00:21:36,150 --> 00:21:39,910
+to minimize the backflow يعني التطفق للخارج أو
+
+303
+00:21:39,910 --> 00:21:44,810
+للخلف بعد التبوسيت في الفاجينة نقطة تانية to
+
+304
+00:21:44,810 --> 00:21:50,850
+protect the spermatozoa or sperm from the acidic
+
+305
+00:21:50,850 --> 00:21:55,170
+pH of vaginaand to protect them from immune attack
+
+306
+00:21:55,170 --> 00:21:59,670
+يعني تلت أسباب ووظائف للـ coagulant المادة
+
+307
+00:21:59,670 --> 00:22:02,590
+الجلوتانية التي تحيط بالـ sperm حماية من الـ
+
+308
+00:22:02,590 --> 00:22:05,450
+acidic pH الموجودة في الفاجينة حماية من ال immune
+
+309
+00:22:05,450 --> 00:22:09,390
+system attack أو الimmune attack ومنع ال back
+
+310
+00:22:09,390 --> 00:22:15,050
+follow بعد الدوبوزيشن اللي بيصير في الفاجينةمادة
+
+311
+00:22:15,050 --> 00:22:17,650
+أخرى موجودة في الـ seminal fluid وتساعد على
+
+312
+00:22:17,650 --> 00:22:22,090
+الليكوفيكاشن هي البروستاتا specific antigen بقعة
+
+313
+00:22:22,090 --> 00:22:25,950
+اللي عاوز أسموها البروستاتيك specific antigen ABCA
+
+314
+00:22:25,950 --> 00:22:30,510
+هذه تلعب
+
+315
+00:22:30,510 --> 00:22:35,390
+دور كبير جدا ومهم في تكسير الكواكولوم علشان تعمل
+
+316
+00:22:35,390 --> 00:22:41,730
+تحرر للسبيرماتوزوة مصدرها بشكل أساسي لبروستاتا في
+
+317
+00:22:41,730 --> 00:22:46,010
+أيضا مادة أخرىالـ Vibrinolysis Vibrinolysis هو
+
+318
+00:22:46,010 --> 00:22:50,570
+عبارة عن بروتاليتك إنزين يفرز أيضًا من البرستاتا
+
+319
+00:22:50,570 --> 00:22:54,290
+وبيلعب دور مهم جدًا في تكسير الفيبرين المسؤول عن
+
+320
+00:22:54,290 --> 00:22:58,870
+تكوين الـ coagulant which lycophytes the seminal
+
+321
+00:22:58,870 --> 00:23:01,790
+within fifty to thirty minutes the function of
+
+322
+00:23:01,790 --> 00:23:05,790
+this enzyme is gradual طبعًا البرستاتك ال specific
+
+323
+00:23:05,790 --> 00:23:08,330
+انتجن أو البرستاتك ال specific انتجن و ال
+
+324
+00:23:08,330 --> 00:23:12,670
+Vibrinolysis ال Vibrinolysin as enzymeما بيشتغلوا
+
+325
+00:23:12,670 --> 00:23:18,610
+بشكل مفاجئ، لأ بشكل تدريجي ما بيقطع منطقة الـ
+
+326
+00:23:18,610 --> 00:23:21,890
+cervical إلا بيكون صارله complete liquefaction هذا
+
+327
+00:23:21,890 --> 00:23:25,890
+بالوضع الطبيعي، عشان كده بتاخد من 15 أقل شيء إلى
+
+328
+00:23:25,890 --> 00:23:30,590
+30 الـ liquefaction كان okay رأي رومتون بريتشار
+
+329
+00:23:30,880 --> 00:23:36,280
+ويمكننا إستعمال ذلك باستخدام مخزن لدرجة 37 دقائق
+
+330
+00:23:36,280 --> 00:23:37,960
+مستمر في المزيد من المزيد من المزيد من المزيد من
+
+331
+00:23:37,960 --> 00:23:40,380
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+332
+00:23:40,380 --> 00:23:40,820
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+333
+00:23:40,820 --> 00:23:47,520
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+334
+00:23:47,520 --> 00:23:51,480
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+335
+00:23:51,480 --> 00:23:51,500
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+336
+00:23:51,500 --> 00:23:51,500
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+337
+00:23:51,500 --> 00:23:51,500
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+338
+00:23:51,500 --> 00:23:51,500
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+339
+00:23:51,500 --> 00:23:58,010
+المزيد من المزيد من المزيد من المزيدالprocess of
+
+340
+00:23:58,010 --> 00:24:01,050
+liquefaction is significant as it allows for
+
+341
+00:24:01,050 --> 00:24:04,410
+impolized sperm to become motile مهم جدا عشان تسمح
+
+342
+00:24:04,410 --> 00:24:07,790
+للـ spermatozoa أنها تتحرك، ما تكون عالقة داخل
+
+343
+00:24:07,790 --> 00:24:12,110
+الشبكة، if the semen fails to liquefy it, it can
+
+344
+00:24:12,110 --> 00:24:17,670
+be indicative of a glandular dysfunction of the
+
+345
+00:24:17,670 --> 00:24:20,750
+prostata والله بعد نص ساعة ما أصلحش liquefaction
+
+346
+00:24:20,750 --> 00:24:24,780
+لعينة، استنيت كمان 35، كمان 5 دقايقخمس و تلاتين،
+
+347
+00:24:24,780 --> 00:24:27,440
+اربعين، خمس و اربعين، خمسين ماصارش liquefication
+
+348
+00:24:27,440 --> 00:24:30,820
+إذا أنا بعرف إن فيه أنا عندي مشكلة في البروستاتا
+
+349
+00:24:30,820 --> 00:24:33,720
+لإن هي اللي بتفرز البروستاتا ال specific antigen و
+
+350
+00:24:33,720 --> 00:24:37,760
+ال fibrinolysis أو fibrinolysin as a proteolytic
+
+351
+00:24:37,760 --> 00:24:40,720
+enzyme معناه في عندي dysfunction اللي فيه
+
+352
+00:24:40,720 --> 00:24:45,020
+البروستاتا ال abnormality الخاصة بال liquefication
+
+353
+00:24:45,020 --> 00:24:49,360
+أسبابها عندي ejaculatory duct obstruction في عندي
+
+354
+00:24:49,360 --> 00:24:51,400
+obstruction في ال ejaculatory duct في القضايا
+
+355
+00:24:51,400 --> 00:24:56,070
+القادرةفيها اندى congenital absence للسمن physical
+
+356
+00:24:56,070 --> 00:25:00,690
+الناقل أو فيها اندى genital tract infection وهي
+
+357
+00:25:00,690 --> 00:25:06,370
+تعتبر من أكثر الأسباب شيوعا لحدوث elongation in
+
+358
+00:25:06,370 --> 00:25:09,850
+the duration of .. in the duration time of السمن
+
+359
+00:25:09,850 --> 00:25:13,670
+liquification يعني زيادة أكثر الأسباب انتشارا
+
+360
+00:25:13,670 --> 00:25:19,230
+والتي تؤدي إلى زيادة الوقت المستهلك لتميُع السائل
+
+361
+00:25:19,230 --> 00:25:25,630
+هي عبارة عن ال genital tract infectionالنوع التاني
+
+362
+00:25:25,630 --> 00:25:28,850
+أو ال test التاني من ال macroscopic هي عبارة عن ال
+
+363
+00:25:28,850 --> 00:25:32,910
+viscosity اللزوجة طبعا after liquification تصل
+
+364
+00:25:32,910 --> 00:25:36,210
+liquification بعد نص ساعة كل الفحوصات مباحة يعني
+
+365
+00:25:36,210 --> 00:25:39,450
+ممكن أنت تستطيع أن تعمل أي فحص بعد ال
+
+366
+00:25:39,450 --> 00:25:41,930
+liquification قبل ال liquification ممنوع تعمل أي
+
+367
+00:25:41,930 --> 00:25:46,050
+فحص حتى لو كان فحص بسيط جدا ال viscosity referred
+
+368
+00:25:46,050 --> 00:25:49,390
+to elastic properties of the sample after
+
+369
+00:25:49,390 --> 00:25:53,110
+liquification يعني أنا بشوف ميعدتها كيف؟ بشوف
+
+370
+00:25:53,110 --> 00:25:56,700
+لزوجتها كيف؟بشوف قوامها كيف، قوام مين؟ قوام العينة
+
+371
+00:25:56,700 --> 00:25:59,380
+اللي عبارة عن السمن طب كيف بتعملها عملية
+
+372
+00:25:59,380 --> 00:26:02,740
+evaluation ببساطة جدا بجيب dropper، plastic
+
+373
+00:26:02,740 --> 00:26:07,060
+dropper، استراعي بعمل mixing و باخد العينة كلها و
+
+374
+00:26:07,060 --> 00:26:11,780
+برفع إيدي و بعمل dropping بشوف السمن ال fluid بنزل
+
+375
+00:26:11,780 --> 00:26:15,840
+قطرة قطرة ولا بنزل على هذه ال line و ال line اللي
+
+376
+00:26:15,840 --> 00:26:19,240
+بنزل جدش تورو تقديرا، مش بجيب مصدر وقيص، لأ تقديرا
+
+377
+00:26:19,240 --> 00:26:23,960
+فإذا كانت بنزل drop by dropمعناه انه liquification
+
+378
+00:26:23,960 --> 00:26:29,020
+طبيعية و الviscosity طبيعية والله نزل على شكل ال
+
+379
+00:26:29,020 --> 00:26:33,300
+line طوله 2 cm تقريبا إذا بسميها hyperviscosity من
+
+380
+00:26:33,300 --> 00:26:37,220
+2 إلى 4 slightly hyperviscosity من 4 إلى 6
+
+381
+00:26:37,220 --> 00:26:42,500
+moderate hyperviscosity أكتر من 6 cm معناها higher
+
+382
+00:26:42,500 --> 00:26:48,380
+hyperviscosity هذه فكرة الviscosity معظمه يكون ما
+
+383
+00:26:48,380 --> 00:26:52,830
+بين hyper و slightlyولكن في ناس بتكون normal drop
+
+384
+00:26:52,830 --> 00:26:57,710
+by drop الـ abnormal viscosity وجدوا أنها لها
+
+385
+00:26:57,710 --> 00:27:03,030
+علاقة بأمر معين وهو hypofunction of prostata or
+
+386
+00:27:03,030 --> 00:27:06,450
+seminal vesicle يعني عندي reduction في الـ
+
+387
+00:27:06,450 --> 00:27:10,530
+functional المتعلقة بالبرستاتكي gland و ال seminal
+
+388
+00:27:10,530 --> 00:27:14,610
+vesicle علما عندي مشكلة في ال functional إذا كلا
+
+389
+00:27:14,610 --> 00:27:16,790
+المنطقتين سواء كانت البرستاتا أو ال seminal
+
+390
+00:27:16,790 --> 00:27:21,180
+vesicle لن تستطيع إخراج محتوىهافبالتالي، هيكون
+
+391
+00:27:21,180 --> 00:27:23,360
+عندي مشكلة في الـ liquefication ومشكلة في
+
+392
+00:27:23,360 --> 00:27:26,460
+الviscosity on the other hand, infection and
+
+393
+00:27:26,460 --> 00:27:30,100
+inflammation of accessory gland or other male
+
+394
+00:27:30,100 --> 00:27:32,860
+fertility related disease may also lead to semen
+
+395
+00:27:32,860 --> 00:27:36,800
+hyperviscosity in men with functionally normal
+
+396
+00:27:36,800 --> 00:27:40,760
+accessory gland في بعض الأحيان، ممكن يكون عندي ال
+
+397
+00:27:40,760 --> 00:27:44,680
+functional gland normal 100%ولكن في مشكلة عندى في
+
+398
+00:27:44,680 --> 00:27:47,720
+الviscosity بيكون سببها infection او inflammation
+
+399
+00:27:47,720 --> 00:27:51,900
+في ال accessary gland فممكن انا اطلق عليها و
+
+400
+00:27:51,900 --> 00:27:55,640
+اشخصها عفوا من خلال اعمل مظرة على ال seminal fluid
+
+401
+00:27:55,640 --> 00:27:59,860
+زي ما بعمل مظرة على ال urine بعمل مظرة على ال
+
+402
+00:27:59,860 --> 00:28:04,680
+seminal fluid ال hyperviscosity has been shown to
+
+403
+00:28:04,680 --> 00:28:07,980
+be ايش ال hyperviscosity اسبابها what is the
+
+404
+00:28:07,980 --> 00:28:11,460
+reasons of hyperviscosity اول حاجة وجدوا انها
+
+405
+00:28:11,460 --> 00:28:17,790
+associated% of motility spermatozoa بمعنى آخر
+
+406
+00:28:17,790 --> 00:28:20,890
+خلّيني أسميها رغم إن عرفنا في النقطة الأولى
+
+407
+00:28:20,890 --> 00:28:25,530
+أسبابها زي الـ Hypofunctional Prostatic أو الـ
+
+408
+00:28:25,530 --> 00:28:27,750
+Hypofunctional Seminal Vesicle أو عنده
+
+409
+00:28:27,750 --> 00:28:30,890
+Inflammation أو Infection طب الـ Hyperfiscosity
+
+410
+00:28:30,890 --> 00:28:36,350
+لإيش تؤدي؟ إيش مخاطرها؟ إيش الـ side effect تبعها؟
+
+411
+00:28:36,350 --> 00:28:40,460
+الـ side effect أول حاجة بتعملي لاورأو الـ
+
+412
+00:28:40,460 --> 00:28:43,580
+reduction in the percentage of motile sperm نسبة
+
+413
+00:28:43,580 --> 00:28:46,060
+الـ motile sperm بتكون قليلة جدا لإن ال sperm
+
+414
+00:28:46,060 --> 00:28:52,020
+بيكون محصور داخل شبكة اتنين indicative of a
+
+415
+00:28:52,020 --> 00:28:54,700
+deficiency in the functional activity of accessory
+
+416
+00:28:54,700 --> 00:28:58,340
+6 glands لما تكون ال viscosity عالية معناه أنه أنا
+
+417
+00:28:58,340 --> 00:29:02,760
+عند مشكلة في وظائف الغدد الجنسية أو الغدد المساعدة
+
+418
+00:29:02,760 --> 00:29:08,520
+ل ال reproductive system عند المن نجلد نوع تالت من
+
+419
+00:29:08,520 --> 00:29:14,010
+أنواعالـ Macroscopic Examination و هو الـ pH طبعا
+
+420
+00:29:14,010 --> 00:29:18,170
+في عندي accessor gland أو accessor 6 gland هي التي
+
+421
+00:29:18,170 --> 00:29:23,930
+تساهم في إنتاج الـ pH الخاص بالـ seminal fluid على
+
+422
+00:29:23,930 --> 00:29:28,070
+سبيل المثال الـ seminal is multiglandular in
+
+423
+00:29:28,070 --> 00:29:31,050
+origin with the acetic prostata and alkaline
+
+424
+00:29:31,050 --> 00:29:36,330
+seminal vesicle يعني البرستاتة بتفرز fluid acid و
+
+425
+00:29:36,330 --> 00:29:37,950
+ال seminal vesicle بتفرز
+
+426
+00:29:41,680 --> 00:29:46,440
+مين بتغير تاني بيديني تكوين الـ pH الخاص بالسمن
+
+427
+00:29:46,440 --> 00:29:51,440
+وهو high pH يعني ايش يعني high pH؟ يعني أكبر من 7
+
+428
+00:29:51,440 --> 00:29:56,340
+يعني alkaline combining to produce alkaline fluid
+
+429
+00:29:56,340 --> 00:30:01,200
+with the high pH range from 7.2 ل 8 إذا نخدوا
+
+430
+00:30:01,200 --> 00:30:04,720
+بالكم هنا من النقطة صحيح إنه في عندك بروستاتا
+
+431
+00:30:04,720 --> 00:30:08,660
+بتتفرز acidic fluid وصحيح عندك في سمنال physically
+
+432
+00:30:08,660 --> 00:30:12,420
+بتتفرز alkaline fluidوالاتنين الـ fluid يلتقوا في
+
+433
+00:30:12,420 --> 00:30:16,840
+مجلة واحد وهو الـ ejaculatory duct ولكن الـ pH تبع
+
+434
+00:30:16,840 --> 00:30:20,240
+الـ seminal physical يطغى على الـ pH تبع ال
+
+435
+00:30:20,240 --> 00:30:23,440
+prostatic لأن كمية ال fluid اللي جاي من ال seminal
+
+436
+00:30:23,440 --> 00:30:27,660
+physical أعلى فبالتالي بيعطي ال pH ال alkaline
+
+437
+00:30:27,660 --> 00:30:32,920
+الخاص بال seminal fluid ال pH اللي ليه عبارة من 7
+
+438
+00:30:32,920 --> 00:30:41,720
+.2 ل 8 ال pH إذا كان أقل من 7 بكون أسبابهاأو تقنين
+
+439
+00:30:41,720 --> 00:30:45,740
+مؤشر أنه في congenital absent في ال vas deferens
+
+440
+00:30:45,740 --> 00:30:49,680
+أو obstruction في ال ejaculatory duct يعني لما أجى
+
+441
+00:30:49,680 --> 00:30:52,960
+ال pH على طريق ال stream أقل من 7 تقسم من ال fluid
+
+442
+00:30:52,960 --> 00:30:57,580
+بقول والله ممكن يكون absent في ال congenital أو
+
+443
+00:30:57,580 --> 00:31:00,420
+يعني بمعنى absent في ال vas deferens وهذا طبيعة ال
+
+444
+00:31:00,420 --> 00:31:03,840
+absent congenital يعني الذكر هذا مولود بال absent
+
+445
+00:31:03,840 --> 00:31:08,400
+منذ الولادة أو في عندي انسداد في ال ejaculatory
+
+446
+00:31:08,400 --> 00:31:15,620
+duct القناة القادفةلو زاد ال pH عن 7.8 أو زاد عن 8
+
+447
+00:31:15,620 --> 00:31:19,620
+صار more alkaline أسبابها أو بيعطيني indication
+
+448
+00:31:19,620 --> 00:31:22,120
+أنه و الله عندي فيه مشكلة في ال seminal vesicle
+
+449
+00:31:22,120 --> 00:31:25,560
+حاجة بنسميها dysfunctional seminal vesicle
+
+450
+00:31:25,560 --> 00:31:30,260
+dysfunctional seminal vesicle إذن ال normal range
+
+451
+00:31:30,260 --> 00:31:34,340
+عرفناه لل pH لل seminal fluid إن زاد ال pH و إن قل
+
+452
+00:31:34,340 --> 00:31:38,940
+ال pH بيعتبر indicative و indication على شو بالضبط
+
+453
+00:31:40,780 --> 00:31:44,220
+كدا بيكون خلصنا ال microscopic التي تورا بالعين
+
+454
+00:31:44,220 --> 00:31:48,680
+المجردة سننتقل إلى موضوع جديد له علاقة بال
+
+455
+00:31:48,680 --> 00:31:53,740
+microscopic examination و هذا الكلام ان شاء الله
+
+456
+00:31:53,740 --> 00:32:00,640
+هنمشي فيه بخطة على أمل انه نبسط بعض النقاط ال
+
+457
+00:32:00,640 --> 00:32:04,140
+microscopic examination أول مصطلح اللي بنحكي فيه و
+
+458
+00:32:04,140 --> 00:32:08,940
+هو أهم مصطلح هو ال spare concentration خدوا بالك
+
+459
+00:32:08,940 --> 00:32:14,200
+keep in your mindThere are two terms sperm
+
+460
+00:32:14,200 --> 00:32:18,460
+concentration and total sperm count دولة different
+
+461
+00:32:18,460 --> 00:32:24,360
+term sperm concentration معناه ببساطة عدد
+
+462
+00:32:24,360 --> 00:32:28,540
+الحيوانات في ملي لتر واحد يعني انا عندى ملي لتر
+
+463
+00:32:28,540 --> 00:32:31,760
+واحد اكتر حيوان منوي اكتر نطفة موجودة عندى هذا
+
+464
+00:32:31,760 --> 00:32:37,600
+بسميها لإنه صار في حجم معين و هو one milliliter
+
+465
+00:32:37,600 --> 00:32:42,430
+بسميه sperm concentration ال spermالـ total count
+
+466
+00:32:42,430 --> 00:32:46,150
+هو عبارة عن عدد الحيوانات المنوية في العينة ككل
+
+467
+00:32:46,150 --> 00:32:51,210
+كيف تحسب؟ بقول ال total sperm count يساوي ال sperm
+
+468
+00:32:51,210 --> 00:32:54,910
+concentration ضرب ال total volume يعني لو أنا اللي
+
+469
+00:32:54,910 --> 00:32:59,050
+جيت ببساطة عندي خمسة مليون as sperm concentration
+
+470
+00:32:59,050 --> 00:33:02,610
+في الواحد مل وعندي ال total volume خمسة إذا ال
+
+471
+00:33:02,610 --> 00:33:07,660
+total sperm count خمسة في خمسة وعشرين مليونSperm
+
+472
+00:33:07,660 --> 00:33:12,100
+concentration can be assessed by homocytometer هذه
+
+473
+00:33:12,100 --> 00:33:14,960
+طريقة من طرق القياس وهي التي تعتبر reference
+
+474
+00:33:14,960 --> 00:33:20,180
+method ال macular هو عبارة عن slide خاصة بال
+
+475
+00:33:20,180 --> 00:33:24,200
+seminal fluid يستخدم في ال fertility center وال
+
+476
+00:33:24,200 --> 00:33:28,260
+slide method وهي عبارة عن طريقة روتينية لها طريقة
+
+477
+00:33:28,260 --> 00:33:33,920
+معينة في القياس الأصح يابتستخدم macular يابتستخدم
+
+478
+00:33:33,920 --> 00:33:38,490
+homocytometer هذا صحThe concentration of the semen
+
+479
+00:33:38,490 --> 00:33:43,110
+depending on what يعني عدد الحيوانات في ال one
+
+480
+00:33:43,110 --> 00:33:46,790
+milliliter تعتمد على شغل أول حاجة تعتمد على volume
+
+481
+00:33:46,790 --> 00:33:50,450
+of testis حجم ال testis جدش كل ما زاد الحجم
+
+482
+00:33:50,450 --> 00:33:55,210
+المنطقي يقول هيزيد عملية التصنيع، هيزيد المخزون،
+
+483
+00:33:55,210 --> 00:34:00,070
+هيزيد عدد الحيوانات المقضوفة اتنين ال period of
+
+484
+00:34:00,070 --> 00:34:03,550
+sexual absence هل امتنع عن ال intercourse أو ال
+
+485
+00:34:03,550 --> 00:34:06,630
+ejaculation تلت أيام ولا أسبوع؟طبعاً هذا منطق كل
+
+486
+00:34:06,630 --> 00:34:09,950
+ما زاد الإمتناع زادت عملية التحصيل والتخزين
+
+487
+00:34:09,950 --> 00:34:14,890
+فبالتالي زاد عملية ال sperm اللي مقضوف ال size of
+
+488
+00:34:14,890 --> 00:34:19,930
+epidermal sperm منطقي كل ما زاد ال size يعني كل ما
+
+489
+00:34:19,930 --> 00:34:23,910
+زاد المستودع كل ما زادت عملية التخزين إذن تلت عوام
+
+490
+00:34:23,910 --> 00:34:29,030
+الأساسية هي التي تساهم وتعتمد عليها عدد الحيوانات
+
+491
+00:34:29,030 --> 00:34:32,770
+المنوية أو ما يُعرف باسم ال sperm concentration
+
+492
+00:34:32,770 --> 00:34:40,660
+sperm morphologyمن أشهر وأهم الـ Parameter احنا
+
+493
+00:34:40,660 --> 00:34:43,660
+عارفين دايما ان الـSperm بتكون من head و neck و
+
+494
+00:34:43,660 --> 00:34:47,460
+mid piece و tail ال head فيه الأكرزوم و فيه ال
+
+495
+00:34:47,460 --> 00:34:53,720
+nuclear acid ال mid piece فيها متاكندرية و ال
+
+496
+00:34:53,720 --> 00:34:57,420
+flagella أو ال tail مسئولة عن الحركة طبعا هذه
+
+497
+00:34:57,420 --> 00:35:00,220
+الصورة هي عبارة عن ال normal shape او ال normal
+
+498
+00:35:00,220 --> 00:35:04,560
+form لـSpermفي بعض الأحيان في عندي abnormal form
+
+499
+00:35:04,560 --> 00:35:10,940
+زي زيادة في ال head size نقصان في ال head size
+
+500
+00:35:10,940 --> 00:35:20,520
+نقصان في ال head size نقصان في ال head size نقصان
+
+501
+00:35:20,520 --> 00:35:22,080
+في ال head size نقصان في ال head size نقصان في ال
+
+502
+00:35:22,080 --> 00:35:22,320
+head size نقصان في ال head size نقصان في ال head
+
+503
+00:35:22,320 --> 00:35:22,420
+size نقصان في ال head size نقصان في ال head size
+
+504
+00:35:22,420 --> 00:35:23,260
+نقصان في ال head size نقصان في ال head size نقصان
+
+505
+00:35:23,260 --> 00:35:25,060
+في ال head size نقصان في ال head size نقصان في ال
+
+506
+00:35:25,060 --> 00:35:26,240
+head size نقصان في ال head size نقصان في ال head
+
+507
+00:35:26,240 --> 00:35:28,540
+size نقصان في ال head size نقصان في ال head size
+
+508
+00:35:28,540 --> 00:35:29,880
+نقصان في ال head size نقصان في ال head size نقصان
+
+509
+00:35:29,880 --> 00:35:29,880
+في ال head size نقصان في ال head size نقصان في ال
+
+510
+00:35:29,880 --> 00:35:31,560
+head size نقصان في ال head size نقabnormal
+
+511
+00:35:31,560 --> 00:35:35,420
+morphology may have an impact on هذه الـ abnormal
+
+512
+00:35:35,420 --> 00:35:37,760
+morphology لما أشوف abnormality عالية في الـ
+
+513
+00:35:37,760 --> 00:35:41,180
+morphology للـ sperm تعطيلي indication على شو؟
+
+514
+00:35:41,180 --> 00:35:44,740
+تعطيلي إن في عندي chromatin condensation بشكل غير
+
+515
+00:35:44,740 --> 00:35:50,180
+طبيعي في عندي أكرزوم أو عفوًا بتأثر على شو؟ بتعمل
+
+516
+00:35:50,180 --> 00:35:53,480
+impact على شو؟ لما يكون عندي abnormality في ال
+
+517
+00:35:53,480 --> 00:35:54,020
+morphology
+
+518
+00:36:10,230 --> 00:36:16,610
+الحركة نشاط الأكرزوم الاببتوسس كلهم يتأثروا
+
+519
+00:36:16,610 --> 00:36:19,590
+بالمورفولوجي يعني بمعنى آخر أن المورفولوجي السيء
+
+520
+00:36:19,590 --> 00:36:23,950
+يتأثر عليه بشكل سيءSpecific morphological defects
+
+521
+00:36:23,950 --> 00:36:29,170
+such as multiple tail abnormalities or headless
+
+522
+00:36:29,170 --> 00:36:33,870
+spermatozoa may be associated with genetic
+
+523
+00:36:33,870 --> 00:36:37,650
+abnormality يعني في عندي بعض الـ abnormal form
+
+524
+00:36:37,650 --> 00:36:41,670
+اللي علاقة بالgenetic زي فقدان ال head على سبيل
+
+525
+00:36:41,670 --> 00:36:46,070
+المثال أو وجود أكتر من tail وجود أكتر من tail زي
+
+526
+00:36:46,070 --> 00:36:50,210
+ما أحنا شايفين في رقم تلاتة من جهة اليمين قد يكون
+
+527
+00:36:50,210 --> 00:36:55,370
+genetical abnormalityصورة بتوضح الـ abnormal بالـ
+
+528
+00:36:55,370 --> 00:37:01,870
+head double head يعني
+
+529
+00:37:01,870 --> 00:37:04,630
+حاجة مثل الـ cytoplasmic droplet بين head بين head
+
+530
+00:37:04,630 --> 00:37:08,850
+في هنا أشكال في ال mid piece و هنا أشكال في ال
+
+531
+00:37:08,850 --> 00:37:14,390
+tail طبعا أنا ما بميل أن أحفظ الأشكال ولكن أميل أن
+
+532
+00:37:14,390 --> 00:37:19,090
+يكون في عندي صورة كاملة لكل ال abnormal form or
+
+533
+00:37:19,090 --> 00:37:22,830
+morphology موجودة أمام ال technician علشان يقدر
+
+534
+00:37:23,160 --> 00:37:30,000
+يصنف شكل آخر بوضّحلي الـ abnormal form الممكن أنا
+
+535
+00:37:30,000 --> 00:37:33,140
+ك recognition ألجيها تحت ال microscope أشكال اللي
+
+536
+00:37:33,140 --> 00:37:36,060
+علاقة بال head defect أشكال اللي علاقة بال mid
+
+537
+00:37:36,060 --> 00:37:40,760
+piece or neck defect أشكال اللي علاقة بال tail
+
+538
+00:37:40,760 --> 00:37:45,520
+defect يعني على سبيل عملي و اللي أنا شوفته شوفت ال
+
+539
+00:37:45,520 --> 00:37:51,320
+megalo ال large head شوفت ال pin headشوفت الـ neck
+
+540
+00:37:51,320 --> 00:37:54,740
+بتكون شبه مكسورة زي الرقم اتنين هذه شوفت ال
+
+541
+00:37:54,740 --> 00:38:01,200
+droplet cytoplasm حوالين ال mid piece شوفت ال thin
+
+542
+00:38:01,200 --> 00:38:07,920
+mid piece شوفت ال cloid tail شوفت ال pentail ايضا
+
+543
+00:38:07,920 --> 00:38:11,580
+شوفت ال terminal cloid tail بهذا الشكل يعني في
+
+544
+00:38:11,580 --> 00:38:14,960
+أشكال مختلفة من ال abnormal morphology اللي ممكن
+
+545
+00:38:14,960 --> 00:38:20,650
+انت تشوفها تحت ال microscopeمصطلح له علاقة بال
+
+546
+00:38:20,650 --> 00:38:25,670
+sperm viability وبعض الأحيان بيطلب عليه sperm
+
+547
+00:38:25,670 --> 00:38:30,130
+viability يعني بمعنى آخر حيوية ال sperm هل ال
+
+548
+00:38:30,130 --> 00:38:34,630
+sperm حي أم ميت ال percentage of life ended sperm
+
+549
+00:38:34,630 --> 00:38:38,470
+in the sample and it's indicative of abnormalities
+
+550
+00:38:38,470 --> 00:38:42,850
+in any of the genital organs لما أقوم أن أعمل ال
+
+551
+00:38:42,850 --> 00:38:46,550
+viability test أو ال viability test هد بتعطيني
+
+552
+00:38:46,550 --> 00:38:49,430
+indication جداش في عندك sperm حيكداش في عندي الـ
+
+553
+00:38:49,430 --> 00:38:52,970
+sperm ميت و بتعطيني indication على وجود
+
+554
+00:38:52,970 --> 00:38:56,610
+abnormality في الـ genital organ أو لا طب كيف أنا
+
+555
+00:38:56,610 --> 00:39:01,610
+ممكن أحللها؟ ال analysis of sperm vitality is
+
+556
+00:39:01,610 --> 00:39:04,470
+based on the integrity of the sperm cell membrane
+
+557
+00:39:04,470 --> 00:39:07,730
+هذا ال principle يعني ال vitality test على شو
+
+558
+00:39:07,730 --> 00:39:11,630
+بتعتمد؟ تعتمد على ال integrity تبع ال sperm cell
+
+559
+00:39:11,630 --> 00:39:15,170
+membrane هل في عندي integrity بشكل معقول صحيح؟ هل
+
+560
+00:39:15,170 --> 00:39:20,300
+في عملوcontrolling لـ cell membrane على ما يدخل و
+
+561
+00:39:20,300 --> 00:39:24,760
+ما يخرج من خلية الحيوان المنوي بالشكل المطلوب و لا
+
+562
+00:39:24,760 --> 00:39:27,940
+لأ ممكن انا اعملها evaluation لـ viability
+
+563
+00:39:27,940 --> 00:39:32,720
+باستخدام Iosin-Nigrosin stain او باستخدام الـ hypo
+
+564
+00:39:32,720 --> 00:39:40,550
+osmotic swelling test تلت فحصين مهمين جداbiatility
+
+565
+00:39:40,550 --> 00:39:44,590
+is affected by number of variables such as
+
+566
+00:39:44,590 --> 00:39:47,390
+abnormal spermatogenesis and vascular and
+
+567
+00:39:47,390 --> 00:39:51,710
+prostatic fluid تلت عوامل بأثروا على حيوية ال
+
+568
+00:39:51,710 --> 00:39:55,390
+sperm أول حاجة ال abnormality في spermatogenesis
+
+569
+00:39:55,390 --> 00:39:58,750
+الشغل تاني ع ال abnormal في ال vascular ال
+
+570
+00:39:58,750 --> 00:40:02,310
+vascular أو ال prostatic fluid ال principle ببساطة
+
+571
+00:40:02,310 --> 00:40:06,750
+جدا أن أنا بصبغ ال sperm بصبغة ال sperm إذا كان
+
+572
+00:40:06,750 --> 00:40:10,290
+ميتالـ Integrity تبع الـ cell membrane بتكون
+
+573
+00:40:10,290 --> 00:40:15,310
+defect فبتسنح بدخول الصبغة إذا اللي كان ال sperm
+
+574
+00:40:15,310 --> 00:40:18,910
+live ال Integrity بتكون سليمة فتمنأ دخول الصبغة
+
+575
+00:40:18,910 --> 00:40:23,930
+فبالتالي بشوف أنا ال sperm in live cell membrane
+
+576
+00:40:23,930 --> 00:40:27,790
+remain intact and therefore exclude the dive from
+
+577
+00:40:27,790 --> 00:40:32,990
+penetrating بمعنى آخر إن إذا كان الحيوان المنوي حي
+
+578
+00:40:32,990 --> 00:40:39,850
+يبقى بلونه الطبيعي pale colorفاتح أما إذا كان الـ
+
+579
+00:40:39,850 --> 00:40:44,110
+sperm dead بياخد صبغة النجروسين أعفوا لل أيوزين أو
+
+580
+00:40:44,110 --> 00:40:47,570
+النجروسين و في الغالب صبغة ال أيوزين بتكون pink
+
+581
+00:40:47,570 --> 00:40:50,070
+color فبياخد اللون ال pink و هنشوفها كمان شوية
+
+582
+00:40:50,070 --> 00:40:56,090
+بصورة متى تستخدم و يجرى فحص ال viability عشان كده
+
+583
+00:40:56,090 --> 00:41:01,110
+بقولك ليس جميع المراكز تقوم بهذه الفرصات ككل تهتم
+
+584
+00:41:01,110 --> 00:41:04,110
+بال concentration و ال motility و ال volume بينما
+
+585
+00:41:04,110 --> 00:41:09,260
+ال viability test يتم إجراءهاإذا كان عدد الـ sperm
+
+586
+00:41:09,260 --> 00:41:13,320
+الـ motility أو ك percentage أقل من 10% يعني لما
+
+587
+00:41:13,320 --> 00:41:17,200
+أنا طالع أتقرر و ألاجى عندى ال motility total
+
+588
+00:41:17,200 --> 00:41:21,400
+motile أقل من 10% المفروض أعمل viability test لأنه
+
+589
+00:41:21,400 --> 00:41:25,500
+قد يكون ال sperm صحيح immotile ولكنه live فبالتالي
+
+590
+00:41:25,500 --> 00:41:30,500
+يمكن استخدامه في الحقن المجهري مابروحش أخد
+
+591
+00:41:30,500 --> 00:41:35,740
+testicular biopsy خزعة من ال testesطبعاً هذه
+
+592
+00:41:35,740 --> 00:41:40,040
+الصورة بتوضح الكلام اللي أنا قلته Hi في عندى صبغت
+
+593
+00:41:40,040 --> 00:41:44,080
+بال أيوزين الدد sperm أخد اللون ال pink في منطقة
+
+594
+00:41:44,080 --> 00:41:46,840
+ال head لأن ال integrity تبعت ال cell membrane
+
+595
+00:41:46,840 --> 00:41:51,760
+defect فسمحت بدخول الصبغة أما ال pale color أو ال
+
+596
+00:41:51,760 --> 00:41:55,880
+white color هو عبارة عن ال life sperm فبالتالي ما
+
+597
+00:41:55,880 --> 00:41:58,280
+أخد الصبغة لأن ال integrity تبعت ال cell membrane
+
+598
+00:41:58,280 --> 00:42:02,460
+كما هي فمنعت دخول الصبغة أو إن دخلت الصبغة عملت ال
+
+599
+00:42:02,460 --> 00:42:07,430
+exclusionطبعا هذه معظم النقاط اللي أنا بتتكلم عنها
+
+600
+00:42:07,430 --> 00:42:11,450
+في محاضرة اليوم، نرجو أن نكمل في المحاضرة القادمة
+
+601
+00:42:11,450 --> 00:42:13,950
+إن شاء الله، دوم توم في حفظ الله
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/wi8cqG8vR_Q.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/wi8cqG8vR_Q.srt
new file mode 100644
index 0000000000000000000000000000000000000000..d1728030f0d4f9332a7f395fc13d24efeaac5504
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/wi8cqG8vR_Q.srt
@@ -0,0 +1,1979 @@
+1
+00:00:00,790 --> 00:00:04,650
+باسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:04,650 --> 00:00:10,210
+المرسلين سيدنا محمد وعلى آله وصحبه أجمعين اليوم 
+
+3
+00:00:10,210 --> 00:00:14,230
+سوف نستكمل الجزء الأخير من هذا الـ chapter والذي 
+
+4
+00:00:14,230 --> 00:00:19,850
+سوف يتكلم بشكل أساسي عن الـ culture media بمعنى ما 
+
+5
+00:00:19,850 --> 00:00:24,350
+هي الأوساط التي يمكن أن تستخدم خلال عملية التلقيح 
+
+6
+00:00:24,350 --> 00:00:28,980
+الصناعي، ما هي الأوساط التي يمكن أن تستخدم خلال نضوج 
+
+7
+00:00:28,980 --> 00:00:33,800
+وانضاج البويضات خارج الرحم، وما هي مكونات هذه 
+
+8
+00:00:33,800 --> 00:00:39,080
+الأوساط، وما هي الهدف الأساسي من استخدام هذه 
+
+9
+00:00:39,080 --> 00:00:43,840
+المكونات؟ الـ culture media بشكل عام هي عبارة عن وسط 
+
+10
+00:00:43,840 --> 00:00:48,360
+غذائي يشبه وسط الغذاء التي تكون متواجدة فيه 
+
+11
+00:00:48,360 --> 00:00:52,400
+البويضة، وتستخدم يا إما من أجل إنماء البويضة 
+
+12
+00:00:52,610 --> 00:00:57,150
+واستكمال نموها إذا كانت في مرحلة الـ M1 أو إبقائها 
+
+13
+00:00:57,150 --> 00:01:02,350
+في وسط طبيعي يشبه الوسط الذي سوف تنتقل إليه وهو 
+
+14
+00:01:02,350 --> 00:01:07,370
+عبارة عن رحم السيدة خلال عملية الـ injection. The 
+
+15
+00:01:07,370 --> 00:01:11,390
+optimal cultural media which reflect the changing 
+
+16
+00:01:11,390 --> 00:01:17,770
+need of the developed embryo is important for 
+
+17
+00:01:17,770 --> 00:01:23,260
+success of IVF treatment. يعني بمعنى آخر كل ما كانت 
+
+18
+00:01:23,260 --> 00:01:29,880
+الوسط الزراعي أو الـ media قريبة من الوسط التي يوجد 
+
+19
+00:01:29,880 --> 00:01:35,080
+فيه الـ embryo أو توجد فيه البويضة، كل ما زاد فرصة 
+
+20
+00:01:35,080 --> 00:01:39,040
+نجاح عملية التلقيح أو عملية الحقن المجهرية. الـ 
+
+21
+00:01:39,040 --> 00:01:44,660
+environment بتلعب دور مهم جدا. الضغط الشديد اللى 
+
+22
+00:01:44,660 --> 00:01:48,160
+بتتعرضلها الخلية، بتتعرضله الـ oocyte من oxidative 
+
+23
+00:01:48,160 --> 00:01:52,200
+stress، من pH، من كمية الـ albumin، من كمية البروتين، من 
+
+24
+00:01:52,200 --> 00:01:56,280
+كمية الجلوكوز، من كمية البيروفيت، يجب أن تشبه إلى حد 
+
+25
+00:01:56,280 --> 00:02:00,480
+ما الكمية اللى بتتعرضلها وهي في الـ ovary وهي في 
+
+26
+00:02:00,480 --> 00:02:05,580
+الـ uterus وهي كمان في الـ fallopian tube، فمش هيكون 
+
+27
+00:02:05,580 --> 00:02:10,760
+هناك اختلاف لضمان نجاح عملية الحقن المجهري سواء 
+
+28
+00:02:10,760 --> 00:02:15,370
+كانت البويضة في مرحلة بويضة أو في مرحلة زيجوت أو في 
+
+29
+00:02:15,370 --> 00:02:19,070
+مرحلة الـ embryo، في كل مرحلة من المراحل بيكون 
+
+30
+00:02:19,070 --> 00:02:23,330
+حواليها وسط غذائي في داخل جسم السيدة خاص فيها 
+
+31
+00:02:23,330 --> 00:02:27,070
+يختلف عن الوسط اللي بيكون في الزيجوت أو يختلف عن 
+
+32
+00:02:27,070 --> 00:02:30,630
+الوسط اللي بيكون في الـ embryo، فبالتالي لازم أوفر 
+
+33
+00:02:30,630 --> 00:02:35,590
+وسط غذائي في المعمل يشبه الوسط الغذائي اللي بيكون 
+
+34
+00:02:35,590 --> 00:02:38,650
+في الـ embryo اللي بتكون فيها البويضة، واللي بيكون 
+
+35
+00:02:38,650 --> 00:02:42,450
+فيه البويضة خلال انتقالها في الـ fallopian tube. The 
+
+36
+00:02:42,450 --> 00:02:46,610
+culture media need to meet the metabolic need of 
+
+37
+00:02:46,610 --> 00:02:52,450
+pre-implantation embryo by addressing genetic and 
+
+38
+00:02:52,450 --> 00:02:55,830
+amino acid requirement in stage specific manner.
+
+39
+00:02:55,830 --> 00:03:00,410
+بمعنى آخر أن مرحلة البويضة تحتاج إلى كمية من الـ 
+
+40
+00:03:00,410 --> 00:03:04,350
+amino acid تختلف عن المرحلة الجنينية، تختلف عن 
+
+41
+00:03:04,350 --> 00:03:08,750
+مرحلة الزيجوت، فبالتالي لكل مرحلة احتياجاتها، لازم 
+
+42
+00:03:08,750 --> 00:03:11,330
+أعرف أنا هذه الاحتياجات وأوفرها في الـ culture 
+
+43
+00:03:11,330 --> 00:03:14,810
+media. أول ما تم اكتشاف الـ Culture Media أو الـ 
+
+44
+00:03:14,810 --> 00:03:20,850
+Media الخاصة بالـ IVF كان في عام 1980، في عام 1985 
+
+45
+00:03:20,850 --> 00:03:25,170
+كان أول Media يصرح باستخدامها، وكان يطلق عليها الـ 
+
+46
+00:03:25,170 --> 00:03:32,390
+HITF بمعنى Human Tupule Fluid وهي تشبه إلى حد ما 
+
+47
+00:03:32,390 --> 00:03:36,190
+الـ Media إلى حد كبير جدا الـ media الموجودة in vivo 
+
+48
+00:03:36,190 --> 00:03:40,230
+environment to which the embryo is exposed، يعني 
+
+49
+00:03:40,230 --> 00:03:44,610
+تشبه بشكل كبير جدا الـ media الداخلية التي يتعرض 
+
+50
+00:03:44,610 --> 00:03:48,310
+إليها الـ embryo خلال عملية انتقاله من الـ fallopian 
+
+51
+00:03:48,310 --> 00:03:52,870
+tube إلى الرحم. الهدف الأساسي من الـ culture media 
+
+52
+00:03:52,870 --> 00:03:56,610
+أو الـ embryo culture as a part of human assisted 
+
+53
+00:03:56,610 --> 00:04:00,230
+reproduction is to provide a stable environment 
+
+54
+00:04:00,230 --> 00:04:04,760
+for embryo to grow and develop from fertilization 
+
+55
+00:04:04,760 --> 00:04:10,160
+through the early stage for transfer into the 
+
+56
+00:04:10,160 --> 00:04:14,020
+uterus or cryopreservation. يعني بمعنى بسيط جدا 
+
+57
+00:04:14,020 --> 00:04:17,520
+الهدف الأساسي من الـ embryonic media أو الـ embryo 
+
+58
+00:04:17,520 --> 00:04:22,280
+media هي توفير ظروف مناخية تناسب الجنين في كل 
+
+59
+00:04:22,280 --> 00:04:26,260
+مراحله في المراحل أثناء انتقاله من fallopian tube 
+
+60
+00:04:26,720 --> 00:04:29,500
+في المراحل التي ينغرس فيها في بطانة الرحم، في 
+
+61
+00:04:29,500 --> 00:04:33,440
+المراحل التي تؤهله لعملية الـ Cryopreservation أي 
+
+62
+00:04:33,440 --> 00:04:38,320
+التجميد باستخدام الـ Liquid Nitrogen. فعلى سبيل 
+
+63
+00:04:38,320 --> 00:04:42,900
+المثال، في ميديا تستخدم في الـ cleavage stage في 
+
+64
+00:04:42,900 --> 00:04:46,360
+اليوم الثاني والثالث. شو يعني الـ cleavage stage؟ 
+
+65
+00:04:46,360 --> 00:04:51,360
+شو يعني اليوم الثاني والثالث؟ ببساطة جدا، البويضة 
+
+66
+00:04:51,360 --> 00:04:55,560
+بعد إخصابها بتمر بخمس أيام، كل يوم بيصير فيها 
+
+67
+00:04:55,560 --> 00:04:58,920
+انقسام، انقسام اليوم الأول، وانقسام اليوم الثاني 
+
+68
+00:04:58,920 --> 00:05:02,080
+وانقسام اليوم الثالث، وانقسام اليوم الرابع، وانقسام 
+
+69
+00:05:02,080 --> 00:05:06,500
+اليوم الخامس. هذه كل يوم عبارة عن انقسام، وفي كل يوم 
+
+70
+00:05:06,500 --> 00:05:11,160
+تنتقل من مكان، وفي كل يوم تنتقل من مكان إلى مكان 
+
+71
+00:05:11,160 --> 00:05:16,620
+آخر خلال عملية الانتقال من Fallopian tube إلى 
+
+72
+00:05:16,620 --> 00:05:22,020
+بطانة الرحم ثم الانغراس. فبالتالي احتياجاته في 
+
+73
+00:05:22,020 --> 00:05:25,520
+اليوم الأول للمادة الغذائية تختلف عن اليوم الثاني، 
+
+74
+00:05:25,520 --> 00:05:28,300
+تختلف عن الثالث، تختلف عن الرابع، تختلف عن الخامس 
+
+75
+00:05:28,300 --> 00:05:32,320
+وهكذا، فلازم كل يوم أعرف شو هو اليوم وشو هو 
+
+76
+00:05:32,320 --> 00:05:35,560
+الاحتياجات. فالـ cleavage stage for example دي اثنين 
+
+77
+00:05:35,560 --> 00:05:41,240
+لديها ثلاثة. it has become clear that it is prefer to 
+
+78
+00:05:41,240 --> 00:05:46,420
+transfer at the blastocyst stage day 5 or day 6 
+
+79
+00:05:46,420 --> 00:05:50,160
+for the number of reasons. شو يعني blastocyst؟ شو 
+
+80
+00:05:50,160 --> 00:05:53,860
+يعني morulla؟ هي عبارة عن مرحلة من مراحل تطور 
+
+81
+00:05:53,860 --> 00:05:58,920
+الجنين، هناخدها بإستفادة. سي goat, blastocyst, 
+
+82
+00:05:59,840 --> 00:06:03,300
+morulla، أسماء كثيرة هنتكلم عنها، بس احنا مش 
+
+83
+00:06:03,300 --> 00:06:07,460
+هنستفيد في الحتة هذه، في اللحظة هذه. في عندنا اثنين 
+
+84
+00:06:07,460 --> 00:06:12,100
+مثال، spontaneous conception لـ human embryo does 
+
+85
+00:06:12,100 --> 00:06:16,500
+not normally pass into the uterus until morulla. في 
+
+86
+00:06:16,500 --> 00:06:20,220
+التلقيح الطبيعي وعملية التلقيح الطبيعية الـ 
+
+87
+00:06:20,220 --> 00:06:26,320
+intercourses الـ embryo ما بينتقل إلى الرحم إلا إذا 
+
+88
+00:06:26,320 --> 00:06:29,900
+وصل لمرحلة الموريلا، والموريلا هي عبارة عن خلية 
+
+89
+00:06:29,900 --> 00:06:34,650
+تحتوي بداخلها على أكثر من 32 خلية. هذا تعريف البسيط 
+
+90
+00:06:34,650 --> 00:06:37,870
+خلّينا نعرفها بهذا الشكل حتى الآن، وقدام هناخد 
+
+91
+00:06:37,870 --> 00:06:41,970
+استفادة شوية عن morulla to the early blastocyst 
+
+92
+00:06:41,970 --> 00:06:46,830
+stage and the aortas is like not well equipped to 
+
+93
+00:06:46,830 --> 00:06:50,830
+support the cleavage stage embryo. يعني بيقول لي 
+
+94
+00:06:50,830 --> 00:06:55,970
+ببساطة جدا أنه في الوضع الطبيعي والتلقيح الطبيعي 
+
+95
+00:06:55,970 --> 00:07:02,510
+الـ embryo لن ينتقل إلى الرحم إلا بعد أن تتحول 
+
+96
+00:07:02,510 --> 00:07:08,160
+لموريلا وهي أحد أطوار الجنين إلى Blastocyst، والـ 
+
+97
+00:07:08,160 --> 00:07:13,980
+Blastocyst أكثر من 64 خلية، ببساطة يعني إذا كان 
+
+98
+00:07:13,980 --> 00:07:17,440
+موريلا معناه لسه مش هينزل إلى الرحم، هيظل في الـ 
+
+99
+00:07:17,440 --> 00:07:21,580
+Fallopian tube. وين انتقل لمرحلة Blastocyst؟ هينتقل 
+
+100
+00:07:21,580 --> 00:07:26,980
+إلى الـ Uterus ويصير له Implantation. خدوا بالكم 
+
+101
+00:07:26,980 --> 00:07:30,420
+طالما morulla إلا احتياجاتها، طالما blastocyst إلا 
+
+102
+00:07:30,420 --> 00:07:34,420
+احتياجات مختلفة. الـ gonadotropin stimulation of 
+
+103
+00:07:34,420 --> 00:07:38,400
+the ovary to provide an increased number of oocyte 
+
+104
+00:07:38,400 --> 00:07:42,720
+results in very high circulating concentration of 
+
+105
+00:07:42,720 --> 00:07:47,420
+estrogen that leads to abnormal development and 
+
+106
+00:07:47,420 --> 00:07:50,820
+functional activity of uterus. خلال عملية تحفيز 
+
+107
+00:07:50,820 --> 00:07:54,220
+المبيض، الزوجة والسيدة بتاخد كمية كبيرة جدا من 
+
+108
+00:07:54,220 --> 00:07:58,740
+الهرمونات. هذه الهرمونات تعمل خربة، خلينا نسميها عدم 
+
+109
+00:07:58,740 --> 00:08:04,780
+انتظام في الحالة العامة للسيدة، في الدورة الدموية 
+
+110
+00:08:04,780 --> 00:08:09,460
+للسيدة، في عملية... العمليات التي تحدث في الـ 
+
+111
+00:08:09,460 --> 00:08:12,960
+reproductive system، نسبة إلى وجود كمية كبيرة جدا و
+
+112
+00:08:12,960 --> 00:08:16,180
+تركيز كبير وعالي من الاستروجين في الدورة الدموية. 
+
+113
+00:08:16,180 --> 00:08:19,800
+هذا ممكن يعمل abnormality في development of 
+
+114
+00:08:19,800 --> 00:08:23,400
+unfunctional activity of uterus. يعني بمعنى آخر 
+
+115
+00:08:23,750 --> 00:08:28,110
+الرحم ما بيعمل بالطريقة المطلوبة في هذه اللحظة. سبب 
+
+116
+00:08:28,110 --> 00:08:32,550
+الثالث. بعض الأحيان بيقولوا الـ culture to blastocyst 
+
+117
+00:08:32,550 --> 00:08:38,550
+stage allowed for more extensive evaluation of the 
+
+118
+00:08:38,550 --> 00:08:44,550
+embryo، خاصة بالـ genetic testing. أنا لما أجي أخلي 
+
+119
+00:08:44,550 --> 00:08:48,250
+الـ embryo في media ليوم أو يومين قبل عملية الإرجاع 
+
+120
+00:08:48,250 --> 00:08:51,610
+هذا بيعطيني فرصة أن أعمل selection. شو يعني 
+
+121
+00:08:51,610 --> 00:08:55,570
+selection؟ أرجع على سبيل المثال الجنين السليم الذي 
+
+122
+00:08:55,570 --> 00:08:59,430
+لا يحتوي على أمراض وراثية، أو أرجع الجنين الذكر أو 
+
+123
+00:08:59,430 --> 00:09:03,370
+أرجع الجنين الأنثى. يعني بتيح لي فترة زمانية كافية أن 
+
+124
+00:09:03,370 --> 00:09:08,210
+أعمل فحوصات جينية على الجنين قبل الإرجاع، مما يضمن 
+
+125
+00:09:08,210 --> 00:09:12,830
+لي بشكل كبير إلى حد ما إرجاع الجنين المطلوب أو 
+
+126
+00:09:12,830 --> 00:09:17,440
+الجنين السليم. في الهند، من أشهر أنواع الـ media اللي 
+
+127
+00:09:17,440 --> 00:09:20,420
+استخدمت هي الـ tissue culture media. الـ tissue 
+
+128
+00:09:20,420 --> 00:09:24,000
+culture media من أشهر هذه الـ media اللي استخدمت 
+
+129
+00:09:24,000 --> 00:09:27,620
+وكانت تحتوي على salt solution، بيحتوي على 
+
+130
+00:09:27,620 --> 00:09:29,480
+Sodium chloride، potassium chloride، calcium 
+
+131
+00:09:29,480 --> 00:09:33,540
+chloride، و low concentration of sodium bicarbonate 
+
+132
+00:09:33,540 --> 00:09:37,860
+عشان تعمل الـ balance في الـ pH. وهذه طبعا إلى حد ما 
+
+133
+00:09:37,860 --> 00:09:43,720
+استخدمت بكمية كبيرة جدا for the study of the frog 
+
+134
+00:09:43,720 --> 00:09:49,270
+heart، نبضات قلب الضفدع، وكانوا يستخدموها... طبعا 
+
+135
+00:09:49,270 --> 00:09:52,870
+كانوا زمان يستخلصوا وينزعوا قلب الضفدع ويضيفوا 
+
+136
+00:09:52,870 --> 00:09:56,030
+عليه الـ Ringer solution اللي هو عبارة عن Sodium 
+
+137
+00:09:56,030 --> 00:09:58,350
+Chloride أو Potassium Chloride أو whatever ويشوف 
+
+138
+00:09:58,350 --> 00:10:02,210
+هل هو بيستجيب لهذه الأملاح، بقد إيش كمية استجابته؟ فهم 
+
+139
+00:10:02,210 --> 00:10:07,150
+بدأوا يستخدموا هذه الـ media إلى الـ IVF أو للـ IVF 
+
+140
+00:10:07,150 --> 00:10:11,230
+بعدها أثبتت كفاءتها، ولكن بعد كده تم تطوير الأمر بشكل 
+
+141
+00:10:11,230 --> 00:10:14,930
+كبير جدا حاليا في عندنا media كاملة و media جاهزة
+
+142
+00:10:15,110 --> 00:10:18,650
+تستخدم بكفاءة عالية جدا إيش موجود في الـ media؟
+
+143
+00:10:18,650 --> 00:10:21,270
+وإيش الـ reagent اللي موجود؟ في عندي media بيسميها
+
+144
+00:10:21,270 --> 00:10:24,650
+cleavage media وفي media بيسميها blastocyst media
+
+145
+00:10:24,650 --> 00:10:28,510
+من اسمها cleavage media يعني media للـ ... mediaة
+
+146
+00:10:28,510 --> 00:10:32,830
+الانقسام الوسط الغذائي للانقسام وهو يستخدم في
+
+147
+00:10:32,830 --> 00:10:36,870
+اليوم الأول والثاني والثالث من الحقن يعني لو أنا
+
+148
+00:10:36,870 --> 00:10:39,950
+حقنت الـ oocyte يوم السبت هستخدم الـ cleavage media
+
+149
+00:10:39,950 --> 00:10:43,910
+يوم السبت والأحد والاثنين، blastocyst media الثلاثاء
+
+150
+00:10:43,910 --> 00:10:47,470
+والأربعاء ليش الثلاثاء والأربعاء؟ أو ليش خمس أيام؟
+
+151
+00:10:47,470 --> 00:10:52,170
+لأن عملية الإرجاع تحدث في اليوم الثالث أو الرابع أو
+
+152
+00:10:52,170 --> 00:10:55,230
+الخامس في الدول المتقدمة، في راجعه في الخامس فإن
+
+153
+00:10:55,230 --> 00:11:00,090
+بيراجعها في الثالث أو الرابع كحد أقصى، فيه طبعًا في
+
+154
+00:11:00,090 --> 00:11:04,290
+الـ media reagents منها اللي هي human serum albumin
+
+155
+00:11:04,290 --> 00:11:08,490
+sperm preparation media هذه أنواع الـ media التي
+
+156
+00:11:08,490 --> 00:11:13,540
+تستخدم خلال الحقن، في عندي الـ Hyaluronidase Media في
+
+157
+00:11:13,540 --> 00:11:15,960
+عند الـ Sperm Preparation Media وفي عند الـ PVP 
+
+158
+00:11:15,960 --> 00:11:19,940
+Media يعني في أنا عندي أربع أنواع من الـ media أو
+
+159
+00:11:19,940 --> 00:11:23,520
+أربع أنواع من الـ reagent تستخدم بشكل كامل في culture 
+
+160
+00:11:23,520 --> 00:11:27,260
+media خاصة بالـ oocyte و الـ embryo أفضل مثال عليها
+
+161
+00:11:27,260 --> 00:11:31,600
+الـ cleavage media و الـ blastocyst media، cleavage
+
+162
+00:11:31,600 --> 00:11:33,780
+media في اليوم الأول والثاني والثالث، و الـ blastocyst في
+
+163
+00:11:33,780 --> 00:11:36,320
+اليوم الرابع والخامس في الـ media اسمها الـ 
+
+164
+00:11:36,320 --> 00:11:39,160
+Hyaluronidase اللي استخدمناها في الـ cumulus 
+
+165
+00:11:39,160 --> 00:11:42,600
+removing، الـ stripping في عندي الـ sperm preparation 
+
+166
+00:11:42,600 --> 00:11:46,120
+media وهذا هنستخدمه في الـ chapter اللي جاي علشان
+
+167
+00:11:46,120 --> 00:11:50,700
+أنا أحصل على single sperm صالح للـ injection وفي
+
+168
+00:11:50,700 --> 00:11:55,060
+عندي الـ BVB media طبعًا هذه الـ BVB media هي عبارة عن
+
+169
+00:11:55,060 --> 00:11:59,120
+intracytoplasmic sperm injection media أو في بعض
+
+170
+00:11:59,120 --> 00:12:02,620
+الأحيان بيسموها media used during injection طبعًا
+
+171
+00:12:02,620 --> 00:12:06,280
+مهمة جدا هذه الـ media ووظيفتها إنها بتقلل قدرة الـ
+
+172
+00:12:06,280 --> 00:12:09,220
+sperm على الـ motility يعني بتعمل reduction in the
+
+173
+00:12:09,220 --> 00:12:13,030
+motility of spermatozoa، تعمل prevent their sticking
+
+174
+00:12:13,030 --> 00:12:18,650
+to the injection pipet بمعنى آخر إن الـ sperm قدرته
+
+175
+00:12:18,650 --> 00:12:21,350
+على الـ motility بتقل يعني أنا بقدر أتحكم بالـ sperm و
+
+176
+00:12:21,350 --> 00:12:25,350
+أعمله catching أيضًا تمنع التصاق الـ sperm بالجدار
+
+177
+00:12:25,350 --> 00:12:31,250
+الداخلي للـ tube فبالتالي أنا الـ sperm بقدر أشوف هو
+
+178
+00:12:31,250 --> 00:12:37,030
+بتحرك داخل الـ tube خلال عملية الإنزال والسحب، During
+
+179
+00:12:37,030 --> 00:12:40,610
+the procedure and to give more control over the
+
+180
+00:12:40,610 --> 00:12:44,970
+flow of a fluid in the injection needle أيضًا بتعطيني
+
+181
+00:12:44,970 --> 00:12:49,010
+قدرة كبيرة جدًا على التحكم بالسائل أثناء دخوله
+
+182
+00:12:49,010 --> 00:12:52,710
+وخروجه من الـ injection needle، الإبرة،  التلقت عشان
+
+183
+00:12:52,710 --> 00:12:59,330
+كثافتها، الكثافة تبعها كافية لإحداث تحكم واضح من
+
+184
+00:12:59,330 --> 00:13:02,170
+الـ reagent اللي يستخدم إضافة إلى الـ culture media
+
+185
+00:13:02,170 --> 00:13:06,020
+اللي هي الـ HTF و الـ C-Spermpreparation media و
+
+186
+00:13:06,020 --> 00:13:10,020
+الـ PVP، في الـ oil طبعًا أنا بستخدم الـ oil بشكل كبير 
+
+187
+00:13:10,020 --> 00:13:14,560
+جدا عشان أغطي الـ media لما أنا بتردش أضيف قطرة
+
+188
+00:13:14,560 --> 00:13:17,320
+drop .. drop .. drop .. drop من الـ media لازم
+
+189
+00:13:17,320 --> 00:13:22,000
+أغطيها بالـ oil هذا الـ oil بيحمي الـ media و بيحمي
+
+190
+00:13:22,000 --> 00:13:25,340
+البويضة اللي موجودة داخل الـ media أو بيحمي الـ
+
+191
+00:13:25,340 --> 00:13:28,280
+embryo اللي موجود داخل الـ media من الـ external
+
+192
+00:13:28,280 --> 00:13:32,480
+environment factors فبيعطيها كمية حرارة ثابتة
+
+193
+00:13:32,480 --> 00:13:37,450
+osmolality ثابتة، pH ثابتة، humidity ثابتة مافي
+
+194
+00:13:37,450 --> 00:13:42,210
+fluctuation، تزحزح، تغير، عدم ثبات، و الـ oil
+
+195
+00:13:42,210 --> 00:13:46,830
+بيعمل لي نوع من أنواع الـ sterilization هائل جدا ده
+
+196
+00:13:46,830 --> 00:13:50,690
+الـ quality of oil can be affected by shipping طبعًا
+
+197
+00:13:50,690 --> 00:13:53,910
+أكيد بتأثر بالـ shipping، بالـ storage، الـ light
+
+198
+00:13:53,910 --> 00:14:00,270
+فبالتالي لازم الـ oil يتم شراؤه من مكان موثوق فيه
+
+199
+00:14:00,270 --> 00:14:04,450
+خاص بالـ IVF مش أي oil يستخدم، The oil type commonly
+
+200
+00:14:04,450 --> 00:14:09,210
+used are mineral oil و paraffin oil و بعض الأحيان
+
+201
+00:14:09,210 --> 00:14:13,270
+الناس بتختار mineral oil، مقرفين يعني هذا أفضل الـ oil 
+
+202
+00:14:13,270 --> 00:14:17,010
+مستخدم، human serum albumin يعتبر من المواد التي
+
+203
+00:14:17,010 --> 00:14:21,930
+تستخدم وتوجد في الـ media بكمية معينة و بدرجة معينة
+
+204
+00:14:21,930 --> 00:14:25,570
+جدا، السبب استخدامه لأنه بيلعب على التوتر السطحي 
+
+205
+00:14:25,570 --> 00:14:29,670
+بيلعب على عامل التوتر السطحي، كيف بيعمل وإيش وظيفته؟
+
+206
+00:14:30,020 --> 00:14:33,200
+بعمل preventing embryo and gamete from sticking
+
+207
+00:14:33,200 --> 00:14:41,440
+to the inner surface of the tube يعني بمعنى آخر بعمل
+
+208
+00:14:41,440 --> 00:14:45,820
+منع لالتصاق الـ embryo أو الجاميطات سواء كانت الـ 
+
+209
+00:14:45,820 --> 00:14:49,520
+oocyte أو الـ sperm أن تلتصق بالجدار الداخلي خلال
+
+210
+00:14:49,520 --> 00:14:53,200
+عملية الـ injection مش منطقي أنا أجي أعمل injection
+
+211
+00:14:53,200 --> 00:14:55,860
+ولاجي الـ sperm مملزج في الجدار الداخلي للـ
+
+212
+00:14:55,860 --> 00:15:01,140
+injection needle مش راضي ينزل، خطأ أنا عملت pools
+
+213
+00:15:01,140 --> 00:15:05,920
+فاشل، injection فاشل فلازم يكون فيه human 
+
+214
+00:15:05,920 --> 00:15:11,320
+serum albumin علشان يقلل الـ sticking، الـ attachment
+
+215
+00:15:11,320 --> 00:15:14,620
+with the inner surface of injection needle
+
+216
+00:15:14,620 --> 00:15:19,020
+Additionally, albumin can protect embryo from toxic
+
+217
+00:15:19,020 --> 00:15:22,500
+substances in the culture environment and act as
+
+218
+00:15:22,500 --> 00:15:26,240
+a buffer مهم جدا أن يحمل embryo من أي toxic material
+
+219
+00:15:26,240 --> 00:15:32,650
+وبيلعب كـ buffer، في embryo بعد تطور الأحداث وتطور
+
+220
+00:15:32,650 --> 00:15:36,270
+الدراسات صار في عندي embryo جديد اسمه sequential 
+
+221
+00:15:36,270 --> 00:15:40,810
+embryo يعني التدريجية أو التتابعية، الـ early
+
+222
+00:15:40,810 --> 00:15:45,510
+culture media used in human IVF tend to be rather
+
+223
+00:15:45,510 --> 00:15:49,010
+simple، very simple، تحتوي على بعض الأملاح
+
+224
+00:15:49,010 --> 00:15:52,930
+والكربونيدرات، والهيدروكربونيات يعني أول ما تم
+
+225
+00:15:52,930 --> 00:15:56,430
+إنشاء الـ media كانت بسيطة جدا، water, sterile water,
+
+226
+00:15:56,550 --> 00:15:59,830
+sterile water, ultra pure water فيها كمية من
+
+227
+00:15:59,830 --> 00:16:03,630
+الأملاح وفيها carbohydrates طيب بعد كده اتغير
+
+228
+00:16:03,630 --> 00:16:07,090
+الموضوع، صاروا يضيفوا أو يستخدموا الـ media الخاصة 
+
+229
+00:16:07,090 --> 00:16:11,630
+بالـ tissue culture وأعطت كفاءة كافية وكفاءة و
+
+230
+00:16:11,630 --> 00:16:17,670
+نتائج معينة، بعد كده تطور الموضوع فصار يدمجوا بعض
+
+231
+00:16:17,670 --> 00:16:20,970
+الأنواع المختلفة من الـ media مع بعض البعض فصار في
+
+232
+00:16:20,970 --> 00:16:25,970
+عندي simple media those lead to amino acids such as 
+
+233
+00:16:25,970 --> 00:16:31,310
+those developed in initial form from mouse and adapted for
+
+234
+00:16:31,310 --> 00:16:34,930
+the human يعني أول أنواع الـ simple media هي عبارة
+
+235
+00:16:34,930 --> 00:16:38,570
+عن الـ simple media التي تفتقر إلى بعض أنواع من
+
+236
+00:16:38,570 --> 00:16:41,710
+الأحماض الأمينية كانوا يستخدموها في البداية علشان
+
+237
+00:16:41,710 --> 00:16:45,530
+الـ embryo الخاص بالـ mouse ويستخدموها مع الـ human 
+
+238
+00:16:45,530 --> 00:16:49,930
+أعطت نتاج، أعطت نتاج، مين مثال عليها؟ مثال عليها الـ 
+
+239
+00:16:49,930 --> 00:16:56,230
+human tubal fluid media ولكن were not effective
+
+240
+00:16:56,570 --> 00:17:00,110
+in supporting a human embryo past the 8-cell stage. صحيح أنها
+
+241
+00:17:00,110 --> 00:17:02,990
+أعطت نتائج في البدايات ولكن لما نصل الـ embryo إلى 
+
+242
+00:17:02,990 --> 00:17:07,610
+8 خلايا ما في لها أهمية، ما في لها أي قيمة فبالتالي
+
+243
+00:17:07,610 --> 00:17:12,150
+أثبتت فشلها مع الـ embryo related with the human
+
+244
+00:17:12,150 --> 00:17:18,210
+عندما يصل إلى 8 خلايا، فاستخدموا sequential media
+
+245
+00:17:18,210 --> 00:17:23,950
+بمعنى آخر، في آخر عشر إلى خمس عشرة سنة صار في عندي
+
+246
+00:17:23,950 --> 00:17:28,030
+shifting بشكل دراماتيكي في تطور الـ media فأصبح
+
+247
+00:17:28,030 --> 00:17:33,790
+يستخدم media للـ cleavage وللـ blastocyst وللـ embryo
+
+248
+00:17:33,790 --> 00:17:36,850
+يعني ثلاثة في واحد، يعني هذه الـ media تصلح لجميع
+
+249
+00:17:36,850 --> 00:17:42,030
+المراحل تطور الجنين، so the stage of cleavage و
+
+250
+00:17:42,030 --> 00:17:44,850
+stage of embryo are cultured in one media 
+
+251
+00:17:44,850 --> 00:17:49,320
+formation of the first one to three days، then
+
+252
+00:17:49,320 --> 00:17:53,280
+subsequently placed into a second media for formation
+
+253
+00:17:53,280 --> 00:17:56,320
+for the next two to three days to support morula
+
+254
+00:17:56,320 --> 00:18:00,960
+and blastocyst development يعني في ... في ... في ...
+
+255
+00:18:00,960 --> 00:18:05,380
+بمعنى آخر، قبل ما يصير تطور للميديا ويصير dramatic
+
+256
+00:18:05,380 --> 00:18:09,040
+shifting بشكل واضح، كانوا يستخدموا media لأول ثلاث
+
+257
+00:18:09,040 --> 00:18:12,980
+أيام بعدين ينقلوا الجنين ويضيفوا media ثانية 
+
+258
+00:18:12,980 --> 00:18:16,620
+لليوم الرابع والخامس، الـ media الأولى مسؤولة عن الـ 
+
+259
+00:18:16,620 --> 00:18:21,810
+development والـ media الثانية مسؤولة عن تدعيم نمو 
+
+260
+00:18:21,810 --> 00:18:27,190
+الموريولا والبلاستوسيست، هذه الـ media قليلًا في
+
+261
+00:18:27,190 --> 00:18:30,990
+مجموعتهم، تغيير مستوى الجلوكوز ومجموعات الطاقة
+
+262
+00:18:30,990 --> 00:18:35,270
+الأخرى كذلك في تغيير المزيد من المزيد من المزيد من
+
+263
+00:18:35,270 --> 00:18:36,010
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+264
+00:18:36,010 --> 00:18:36,490
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+265
+00:18:36,490 --> 00:18:38,490
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+266
+00:18:38,490 --> 00:18:41,310
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+267
+00:18:41,310 --> 00:18:41,610
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+268
+00:18:41,610 --> 00:18:43,730
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+269
+00:18:43,730 --> 00:18:47,680
+المزيد من المزيد من، بالإضافة إلى كمية الـ
+
+270
+00:18:47,680 --> 00:18:51,820
+substrate اللي بتاعة الطاقة، أضف إلى ذلك أنواع
+
+271
+00:18:51,820 --> 00:18:56,340
+الأحماض الأمينية، هذا الاختلاف البسيط ما بينهم صورة
+
+272
+00:18:56,340 --> 00:19:01,020
+بتوضح لي شو يعني الـ common integrity اللي موجودة في
+
+273
+00:19:01,020 --> 00:19:05,640
+الـ sequential culture system في عندي اليوم الأول و
+
+274
+00:19:05,640 --> 00:19:09,640
+اليوم الثاني واليوم الثالث، واليوم الرابع واليوم 
+
+275
+00:19:09,640 --> 00:19:12,440
+الخامس واليوم السادس، هذه عبارة عن أيام الانقسام
+
+276
+00:19:12,440 --> 00:19:16,560
+الستة، في ناس بترجع في اليوم الثالث أو بعد، عفواً 
+
+277
+00:19:16,560 --> 00:19:21,580
+اليوم الثالث وفي ناس بترجع في اليوم الرابع أو
+
+278
+00:19:21,580 --> 00:19:28,160
+الخامس أو السادس، بناءً على كفاءة الجنين وجودته، الـ 
+
+279
+00:19:28,160 --> 00:19:32,800
+sequential media هي عبارة عن media جزء منها أو هي
+
+280
+00:19:32,800 --> 00:19:36,930
+عبارة عن media تتكون من two parts، الـ Part الأول أو 
+
+281
+00:19:36,930 --> 00:19:40,770
+الـ Vial الأول يستخدم من اليوم الأول للتالت والـ 
+
+282
+00:19:40,770 --> 00:19:44,670
+Vial الثاني يستخدم من اليوم الرابع للخامس يحتوي
+
+283
+00:19:44,670 --> 00:19:48,710
+على نفس المواد ولكن بتركيز مختلفة هذا نسميه 
+
+284
+00:19:48,710 --> 00:19:52,390
+Sequential Media التي تستخدم في اليوم الأول للتالت
+
+285
+00:19:52,390 --> 00:19:57,450
+تحتوي على كمية قليلة جدا من الجلوكوز فيها EDTA
+
+286
+00:19:57,450 --> 00:20:00,290
+فيها بيروفيت فيها لاكتيت وما فيها essential amino
+
+287
+00:20:00,290 --> 00:20:04,500
+acid التي تستخدم من اليوم الرابع للسادس فيها 
+
+288
+00:20:04,500 --> 00:20:09,540
+essential amino acid فيها كمية وفيرة من الجلوكوز 
+
+289
+00:20:09,540 --> 00:20:13,960
+فيها بيروفيت وفيها لاكتيت أضف إلى ذلك no
+
+290
+00:20:13,960 --> 00:20:17,680
+essential amino acid no essential amino acid أو 
+
+291
+00:20:17,680 --> 00:20:19,980
+non-essential amino acid مش موجود عفوا فيها
+
+292
+00:20:19,980 --> 00:20:22,700
+non-essential amino acid يعني بمعنى آخر non
+
+293
+00:20:22,700 --> 00:20:25,800
+essential amino acid موجود في ال part الأول موجود
+
+294
+00:20:25,800 --> 00:20:29,330
+في ال part الثاني الجلوكوز موجود في ال part الأول
+
+295
+00:20:29,330 --> 00:20:32,490
+بكمية قليلة في ال part الثاني بكمية أعلى ال bio
+
+296
+00:20:32,490 --> 00:20:35,530
+rate موجود في كلاهما ال lactate موجود في كلاهما ال
+
+297
+00:20:35,530 --> 00:20:38,970
+EDTA موجودة في ال part الأول مش موجودة في ال part
+
+298
+00:20:38,970 --> 00:20:42,190
+الثاني وال part الثاني يختلف عن ال part الأول في
+
+299
+00:20:42,190 --> 00:20:45,250
+وجود ال essential amino acid في وجود ال essential
+
+300
+00:20:45,250 --> 00:20:48,630
+amino acid هذه نسميها sequential cultural media
+
+301
+00:20:48,630 --> 00:20:51,470
+هي عبارة عن ميديا بتتكون من two vials ال file
+
+302
+00:20:51,470 --> 00:20:54,320
+الأول لأول تلت أيام والثاني للتلت أيام التالية
+
+303
+00:20:54,320 --> 00:20:57,440
+ثلاثة أيام وهو الرابع والخامس والسادس أو الرابع 
+
+304
+00:20:57,440 --> 00:21:00,900
+والخمسة والسادس استخدموا هذا الموضوع ب one media
+
+305
+00:21:00,900 --> 00:21:05,660
+وهي media يمكن أن تستخدم من اليوم الأول لليوم
+
+306
+00:21:05,660 --> 00:21:10,220
+السادس فيها non-essential فيها essential فيها
+
+307
+00:21:10,220 --> 00:21:13,820
+EDTA فيها glucose فيها pyruvate وفيها lactate
+
+308
+00:21:13,820 --> 00:21:18,280
+يعني كأنه بيقول لك تحتوي على جميع المواد واللي عاوز
+
+309
+00:21:18,280 --> 00:21:22,200
+الجنين ياخذها اللي عاوزها الموريلا من المواد تاخدها
+
+310
+00:21:22,200 --> 00:21:26,860
+عاوزة بلاستوسيست مواد معينة تاخدها الزيجوت عاوزة من
+
+311
+00:21:26,860 --> 00:21:30,500
+المواد معينة تاخدها والمواد الثانية مايلها side
+
+312
+00:21:30,500 --> 00:21:35,460
+effect عليها أشهر المواد الموجودة الجلوكوز الذي 
+
+313
+00:21:35,460 --> 00:21:40,120
+يعتبر أشهر وأكبر مادة موجودة في ال culture media
+
+314
+00:21:40,120 --> 00:21:46,070
+الجنين بيحتاجه and is one of the primary variables
+
+315
+00:21:46,070 --> 00:21:49,310
+in sequential media culture media أكيد لأنه قلنا
+
+316
+00:21:49,310 --> 00:21:53,890
+الفي ال very low في step one أو ال vial one و very
+
+317
+00:21:53,890 --> 00:21:57,010
+high في ال vial two طبعا ال cleavage stage human
+
+318
+00:21:57,010 --> 00:22:03,050
+embryo can be used glucose ولكن بكميات قليلة يزيد
+
+319
+00:22:03,050 --> 00:22:07,170
+كل ما زاد عمر الجنين ال lactate وال pyruvate the
+
+320
+00:22:07,170 --> 00:22:11,480
+addition of lactate to early salt solution media
+
+321
+00:22:11,480 --> 00:22:16,320
+was instrumental in supporting development from
+
+322
+00:22:16,320 --> 00:22:19,380
+the two cell stage of the mouse embryo وجدوا إن
+
+323
+00:22:19,380 --> 00:22:25,060
+اللاكتات يستخدم بشكل كبير جدا في تدعيم نمو الخلايا
+
+324
+00:22:25,060 --> 00:22:29,260
+أو البويضة الملقحة لما تصل إلى ال two stage خصوصا
+
+325
+00:22:29,260 --> 00:22:34,200
+ال embryo mouse أو ال mouse of embryo البيروفيت تم 
+
+326
+00:22:34,200 --> 00:22:39,290
+فيما بعد اكتشافه واستخدامه أعطى نتائج فعالة في
+
+327
+00:22:39,290 --> 00:22:45,690
+تطوير وتحسين نضوج الزيجوت وتم استخدامه as a
+
+328
+00:22:45,690 --> 00:22:48,970
+primary source of energy for a cleavage stage
+
+329
+00:22:48,970 --> 00:22:52,570
+embryo including a human where it is used
+
+330
+00:22:52,570 --> 00:22:56,210
+throughout development of a blastocyst stage يعني
+
+331
+00:22:56,210 --> 00:22:59,310
+بمعنى آخر البيروفيت أصبح استخدامه أكثر من 
+
+332
+00:22:59,310 --> 00:23:04,250
+اللاكتات as source of energy سواء كان في المرحلة
+
+333
+00:23:04,250 --> 00:23:07,470
+المتقدمة أول ثلاثة أيام أو في مرحلة الـ blastocyst
+
+334
+00:23:07,470 --> 00:23:12,190
+اللي بتظهر في اليوم الرابع أو الخامس أو السادس بعض
+
+335
+00:23:12,190 --> 00:23:16,590
+الأحماض الأمينية التي تلعب دور أساسي كمصدر من مصادر
+
+336
+00:23:16,590 --> 00:23:20,970
+الطاقة المستخدمة من قبل الجنين أثناء عملية ال
+
+337
+00:23:20,970 --> 00:23:24,540
+development ولكن أيضًا تساعد في التدخل في
+
+338
+00:23:24,540 --> 00:23:27,780
+الهوموستازيس داخل الخلايا رغم أنها تعتبر مصدر
+
+339
+00:23:27,780 --> 00:23:33,040
+للطاقة أن الـ Amino Acid أصبحت تستخدم كمصدر مهم
+
+340
+00:23:33,040 --> 00:23:36,320
+جدا للمحافظة على الهوموستازيس داخل الخلايا فهي
+
+341
+00:23:36,320 --> 00:23:40,900
+تعمل كـ Buffering أيضا تعمل كـ Antioxidant وتعمل
+
+342
+00:23:40,900 --> 00:23:45,280
+أيضا Organic Osmolites to control cell volume
+
+343
+00:23:45,280 --> 00:23:49,980
+يعني الـ Amino Acid مادة مش هينة في الـ Culture
+
+344
+00:23:49,980 --> 00:23:55,090
+Media خاصة في بعد اليوم الثالث Amino acid,
+
+345
+00:23:55,290 --> 00:23:58,950
+pyruvate, lactate were recognized as preferred
+
+346
+00:23:58,950 --> 00:24:03,850
+energy source for all or for the early embryo over
+
+347
+00:24:03,850 --> 00:24:08,050
+glucose يعني لو أنا قرنت ال substances كلهم مع ال
+
+348
+00:24:08,050 --> 00:24:12,590
+glucose بلاقي إنه أكثر استخدام لمصادر الطاقة لل
+
+349
+00:24:12,590 --> 00:24:17,070
+embryo وخاصة في المراحل المبكرة يعني أول يومين ثلاثة
+
+350
+00:24:17,070 --> 00:24:21,530
+أيام يستخدم ال amino acid كمصدر للطاقة البيروفيت والـ
+
+351
+00:24:21,530 --> 00:24:27,630
+Lactate يعتبر مفضل أو مفضلين عن الجلوكوز بالنسبة
+
+352
+00:24:27,630 --> 00:24:32,850
+للجنين في أول أيامه في أول أيامه طبعا بعض الدراسات
+
+353
+00:24:32,850 --> 00:24:37,930
+التي أجريت على ال mouse embryo Demonstrated وجدت إن
+
+354
+00:24:37,930 --> 00:24:41,030
+non-essential amino acids are important during
+
+355
+00:24:41,030 --> 00:24:42,610
+early embryo development
+
+356
+00:24:46,110 --> 00:24:48,410
+Essential and non-essential amino acids should
+
+357
+00:24:48,410 --> 00:24:52,450
+be included in the media after 8th to 6th cell
+
+358
+00:24:52,450 --> 00:24:56,450
+stage ايش يعني 6th stage؟ خذوا بالكم اليوم الأول
+
+359
+00:24:56,450 --> 00:25:05,190
+انقسم بقدر 2 cell الثاني 4 الثالث 8 الرابع 16
+
+360
+00:25:05,190 --> 00:25:12,470
+الخامس 32 السادس 64 لأن الأمر مضاعف هي المقصود من
+
+361
+00:25:12,470 --> 00:25:17,360
+الانقسام إذن ال 8 خلايا بيكون في اليوم الثالث لأنه
+
+362
+00:25:17,360 --> 00:25:21,020
+عندي أربعة ثمانية هذه الفكرة الموجودة فبقول لي 
+
+363
+00:25:21,020 --> 00:25:25,080
+ببساطة جدا أن بناء على التجربة وجدوا أن الأحماض
+
+364
+00:25:25,080 --> 00:25:29,220
+الأمينية غير الأساسية تعتبر مهمة لتطور الجنين في 
+
+365
+00:25:29,220 --> 00:25:32,660
+مراحل الأولى بينما الأساسية وغير الأساسية من حيث
+
+366
+00:25:32,660 --> 00:25:37,640
+الأحماض الأمينية تعتبر لتطور ونضوج ونمو الجنين في
+
+367
+00:25:37,640 --> 00:25:42,760
+المراحل بعد اليوم الثالث لما يصل لستة عشر خلية أو
+
+368
+00:25:42,760 --> 00:25:47,720
+ستة عشر خلية يعني في اليوم الثالث واليوم الرابع The
+
+369
+00:25:47,720 --> 00:25:52,780
+use of amino acid and specifically glutamine in
+
+370
+00:25:52,780 --> 00:25:55,700
+the media is associated with ammonium accumulation
+
+371
+00:25:55,700 --> 00:25:59,660
+هل في accumulation للأمونيا بتصير داخل ال media أو 
+
+372
+00:25:59,660 --> 00:26:03,380
+بتصير داخل أكيد في accumulation لأنه خلية
+
+373
+00:26:03,380 --> 00:26:08,600
+والخلية بيطلع منها waste product ووجدوا على سبيل
+
+374
+00:26:08,600 --> 00:26:13,360
+المثال إن embryo واحد في اليوم الرابع يستطيع إنتاج
+
+375
+00:26:13,360 --> 00:26:17,500
+100 micro mole من الأمونيا and the amino acid
+
+376
+00:26:17,500 --> 00:26:21,220
+breakdown added few charge few ذراع to this
+
+377
+00:26:21,220 --> 00:26:24,620
+which can affect the development capacity and 
+
+378
+00:26:24,620 --> 00:26:27,740
+gene expression يعني تصور أنا عندي embryo في اليوم
+
+379
+00:26:27,740 --> 00:26:35,040
+الرابع يعني عدد خلاياه 2، 4، 8، 16 خلية يستطيع إنتاج 
+
+380
+00:26:35,040 --> 00:26:38,760
+100 micromole من الأمونيا بالإضافة إلى وجود
+
+381
+00:26:38,760 --> 00:26:43,560
+الأحماض الأمنية التي تتكسر داخل الوسط أو داخل ال
+
+382
+00:26:43,560 --> 00:26:47,280
+media هيزيد مستوى الأمونيا زيادة مستوى الأمونيا
+
+383
+00:26:47,280 --> 00:26:51,460
+بيعمل feedback أو negative feedback على ال
+
+384
+00:26:51,460 --> 00:26:55,000
+capacity لل gene development لل embryo development
+
+385
+00:26:55,000 --> 00:26:58,520
+وال gene expression يعني في تأثير سلبي على ال
+
+386
+00:26:58,520 --> 00:27:02,960
+gene expression لل embryo والـ capacity التي تتعلق 
+
+387
+00:27:02,960 --> 00:27:07,020
+بالـ embryo development فبالتالي لازم نتخلص منها
+
+388
+00:27:07,020 --> 00:27:12,220
+من خلال وجود system معين في الـ osmolarity and
+
+389
+00:27:12,220 --> 00:27:18,340
+an important concept to be aware of in regard to
+
+390
+00:27:18,340 --> 00:27:22,560
+culture media is osmolarity and it is resulting
+
+391
+00:27:22,560 --> 00:27:26,820
+affecting the cell on the cell volume and embryo 
+
+392
+00:27:26,820 --> 00:27:30,680
+development ال osmolarity لو اختلفت ال volume الخاص
+
+393
+00:27:30,680 --> 00:27:34,420
+بال embryo هيختلف ال development الخاص بال embryo
+
+394
+00:27:34,420 --> 00:27:38,820
+هتختلف فعلى سبيل المثال بناء على التجارب وجدوا أن 
+
+395
+00:27:38,820 --> 00:27:42,500
+ال high osmolarity كان affecting embryo development 
+
+396
+00:27:42,500 --> 00:27:46,980
+and was one of the underlying causes of the two
+
+397
+00:27:46,980 --> 00:27:50,380
+cell blocking observed in early embryo culture
+
+398
+00:27:50,380 --> 00:27:54,060
+media studies شو يعني معنى الكلام؟ وجدوا أن ارتفاع
+
+399
+00:27:54,060 --> 00:27:58,290
+ال osmolarity في ال media خلال حضانة الجنين في هذه
+
+400
+00:27:58,290 --> 00:28:01,830
+الـ media في اليوم الثالث أو اليوم الرابع يؤدي إلى 
+
+401
+00:28:01,830 --> 00:28:06,410
+إيقاف أو اليوم الثاني ممكن يؤدي إلى إيقاف تطوّر
+
+402
+00:28:06,410 --> 00:28:10,510
+الجنين في ال two cell يعني ينقسم في انقسام الأول
+
+403
+00:28:10,510 --> 00:28:14,650
+وانقسام الثاني بس يعني بيقف فقط عند خلية فيها
+
+404
+00:28:14,650 --> 00:28:18,190
+خليتين خلية كبيرة بداخل ال two cell يعني تقريبا
+
+405
+00:28:18,190 --> 00:28:22,150
+يقف في نهاية اليوم الأول وبداية اليوم الثاني ما هو
+
+406
+00:28:22,150 --> 00:28:26,670
+هذا الذي يجعله يوقف انقسام الخلايا؟ blocking a two
+
+407
+00:28:26,670 --> 00:28:32,830
+-cell هو وجود نسبة ومستوى عالي من الـosmolarity so
+
+408
+00:28:32,830 --> 00:28:35,970
+high osmolarity will affect the
+
+409
+00:28:35,970 --> 00:28:39,410
+development of embryo and it is considered as one of the
+
+410
+00:28:39,410 --> 00:28:45,030
+main causes of two-cell block بعض الدراسات التي
+
+411
+00:28:45,030 --> 00:28:49,010
+أجريت على أحماض أمينية مختلفة وجدت أن provided 
+
+412
+00:28:49,010 --> 00:28:52,670
+protection against high osmolarity and are those
+
+413
+00:28:52,670 --> 00:28:57,280
+recommended in all media دراسات حدثت على بعض
+
+414
+00:28:57,280 --> 00:28:59,920
+الأحماض الأمنية وجدت أن هذه الأحماض الأمنية بتلعب
+
+415
+00:28:59,920 --> 00:29:03,360
+دور إيجابي في حماية ال embryo من ال osmolarity
+
+416
+00:29:03,360 --> 00:29:07,240
+فبالتالي بتمنع من ال two cell block بعض ال
+
+417
+00:29:07,240 --> 00:29:11,460
+additives زي ال antioxidant يمكن أن تضاف إلى ال
+
+418
+00:29:11,460 --> 00:29:14,220
+media ومن أشهر هذه ال antioxidant ال pyruvate it
+
+419
+00:29:14,220 --> 00:29:18,620
+will be pyruvate act as a powerful antioxidant
+
+420
+00:29:18,620 --> 00:29:22,680
+فبالتالي بيحمي ال embryo من التأثير السلبي والسيء
+
+421
+00:29:22,680 --> 00:29:28,160
+من أشهر أنواع الـ reactive oxygen species 
+
+422
+00:29:28,160 --> 00:29:33,280
+إيثايل بيروفيت وميثايل بيروفيت وأيضا الـ Antioxidant
+
+423
+00:29:33,280 --> 00:29:37,200
+Sodium Pyruvate بيعتبر من أشهر أنواع الـ 
+
+424
+00:29:37,200 --> 00:29:43,540
+Antioxidant التي قد تستخدم في حماية الـ embryo
+
+425
+00:29:43,540 --> 00:29:50,630
+من الـ oxidative stress وتعمل بشكل كبير جدا على
+
+426
+00:29:50,630 --> 00:29:53,790
+تدعيم الـ embryo الخاص بالماوس خلال عملية الـ
+
+427
+00:29:53,790 --> 00:29:59,170
+development عالية مصدر من مصادر الطاقة مصدر من 
+
+428
+00:29:59,170 --> 00:30:03,030
+مصادر الطاقة فبالتالي الـ Pyruvate مهم جدا في
+
+429
+00:30:03,030 --> 00:30:07,710
+إحداث stability بنسبة و بكمية و بمستوى عالي جدا
+
+430
+00:30:07,710 --> 00:30:13,850
+كمان بعمل increasing لـ membrane permeability
+
+431
+00:30:13,850 --> 00:30:19,190
+factor which could have an impact on both embryo or
+
+432
+00:30:19,190 --> 00:30:24,110
+embryo metabolism or ability to scavenge الرُس
+
+433
+00:30:24,110 --> 00:30:29,950
+يعني مقاومة الرُس التغلب على الرُس الرُس اختصار لل
+
+434
+00:30:29,950 --> 00:30:35,430
+reactive oxygen species وهي very toxic substance
+
+435
+00:30:35,430 --> 00:30:42,050
+harmful harmful harmful سؤال بطرح نفسه هل الجليكوز
+
+436
+00:30:42,050 --> 00:30:47,930
+يعتبر مادة أساسية أو مادة مضرة؟ الجليكوز تُعتبر
+
+437
+00:30:47,930 --> 00:30:53,090
+essential أو harmful substance The toxicity of
+
+438
+00:30:53,090 --> 00:30:57,210
+glucose for the early embryo is controversial
+
+439
+00:30:57,210 --> 00:31:01,930
+بمعنى آخر اختلف العلماء حول تأثير الجليكوز على
+
+440
+00:31:01,930 --> 00:31:05,430
+تطور الجنين في مراحل الأولية بعضهم قال بيأثر
+
+441
+00:31:05,430 --> 00:31:08,650
+التأثير السلبي بعضهم قال يعني toxic وبعضهم قال لأ
+
+442
+00:31:08,650 --> 00:31:11,950
+ما إلو أي علاقة أو ما إلو تأثير  Provost study
+
+443
+00:31:11,950 --> 00:31:15,870
+conclude that glucose is not harmful for the early
+
+444
+00:31:15,870 --> 00:31:22,040
+embryo في المقابل في دراسات ثانية قالت إن الجليكوز
+
+445
+00:31:22,040 --> 00:31:27,640
+والفركتوز يعتبروا من المكونات or fructose is
+
+446
+00:31:27,640 --> 00:31:31,080
+essential and amino acid were considered a key of
+
+447
+00:31:31,080 --> 00:31:34,140
+overcoming two cell blocking possible by
+
+448
+00:31:34,140 --> 00:31:38,280
+regulating the reactive oxygen species يعني بمعنى
+
+449
+00:31:38,280 --> 00:31:44,760
+آخر دراسة أخرى قالت وحدثت أن الجليكوز والفركتوز
+
+450
+00:31:44,760 --> 00:31:48,710
+essential  وamino acid بلعب دور كبير جدا في حماية ال
+
+451
+00:31:48,710 --> 00:31:53,050
+embryo من الرُس ويمنع حدوث ال two cell blocking
+
+452
+00:31:53,050 --> 00:31:57,810
+study showed that the reduction in the embryo
+
+453
+00:31:57,810 --> 00:32:00,010
+quality was associated with the high level of
+
+454
+00:32:00,010 --> 00:32:04,930
+glucose أي دراسة ثانية in another study or in
+
+455
+00:32:04,930 --> 00:32:08,570
+another hand another study found that a media
+
+456
+00:32:08,570 --> 00:32:12,980
+content 4.7 millimole per liter glucose
+
+457
+00:32:12,980 --> 00:32:15,580
+supporting the human embryo development to
+
+458
+00:32:15,580 --> 00:32:20,180
+blastocyst with high effectiveness يعني حتى
+
+459
+00:32:20,180 --> 00:32:25,880
+الدراسات مختلفة علشان كده أنا مابقدر أحكم على مادة
+
+460
+00:32:25,880 --> 00:32:29,840
+إلا بعد أدرسها على المجتمع اللي أنا بعيش فيه لأنه
+
+461
+00:32:29,840 --> 00:32:35,160
+من مجتمع لمجتمع من عدد لعدد تختلف نتائج الدراسة
+
+462
+00:32:35,160 --> 00:32:39,160
+study compared three cultures فيه study عملت 
+
+463
+00:32:39,160 --> 00:32:43,350
+comparing لتأثير تلت أنواع من الـ Media الـ Media
+
+464
+00:32:43,350 --> 00:32:47,090
+الأولى P1 بتحتوى على جليكوز Free مافيش فيها جليكوز
+
+465
+00:32:47,090 --> 00:32:52,750
+يعني و Media اسمها SIM1 بتحتوى على 1 ميلي مول من
+
+466
+00:32:52,750 --> 00:32:57,650
+الجليكوز و Media اسمها Universal IVF Media بتحتوى
+
+467
+00:32:57,650 --> 00:33:02,230
+على 5.55 ميلي مول  for the glucose يعني Media
+
+468
+00:33:02,230 --> 00:33:05,090
+مافيش فيها و ميديا فيها كمية قليلة و ميديا فيها
+
+469
+00:33:05,090 --> 00:33:08,790
+كمية كبيرة جدا طب النتائج ببساطة جدا demonstrate
+
+470
+00:33:08,790 --> 00:33:12,490
+that high concentration did not affect the
+
+471
+00:33:12,490 --> 00:33:17,390
+embryo quality but result in high polyploidy
+
+472
+00:33:17,390 --> 00:33:24,790
+fertilization and affected cleavage rate while SIMI
+
+473
+00:33:24,790 --> 00:33:27,750
+had beneficial effect on the embryo development
+
+474
+00:33:28,360 --> 00:33:32,500
+يعني بمعنى آخر الدراسة استخلصت إن وجود الجليكوز
+
+475
+00:33:32,500 --> 00:33:36,140
+بكميات كبيرة جدا ما بتأثر على جودة الـ embryo
+
+476
+00:33:36,140 --> 00:33:41,980
+كجودة ولكن ممكن تؤدي إلى وجود polyploidy 
+
+477
+00:33:41,980 --> 00:33:46,180
+fertilization ممكن تؤثر على الـ cleavage rate لل
+
+478
+00:33:46,180 --> 00:33:51,160
+embryo بينما النوع الثاني الـ media رقم 2 اللي
+
+479
+00:33:51,160 --> 00:33:57,380
+فيها كمية قليلة وجد إن هيله تأثير إيجابي على نمو
+
+480
+00:33:57,380 --> 00:34:02,500
+وتطور الجنين it has been suggested that glucose is
+
+481
+00:34:02,500 --> 00:34:07,700
+not inhibitor or have negative effect for the
+
+482
+00:34:07,700 --> 00:34:11,380
+early embryo and the concentration that mimics the
+
+483
+00:34:11,380 --> 00:34:15,180
+in vivo condition of avoiding extremely خلاصة هذه
+
+484
+00:34:15,180 --> 00:34:19,960
+الدراسة قالت أن الجليكوز لا يؤثر تأثير سلبي على
+
+485
+00:34:19,960 --> 00:34:26,150
+تطور الجنين ونموه طالما يحاكي نسبته نسبة طبيعية
+
+486
+00:34:26,150 --> 00:34:30,090
+الموجودة في جسم السيدة أو في جسم الأنثى ما لم يزيد
+
+487
+00:34:30,090 --> 00:34:34,510
+ما لم يزيد زيادته ساعتها بيأثر مش على ال quality
+
+488
+00:34:34,510 --> 00:34:40,830
+بيأثر على ال polyploidy بيأثر على ال polyploidy
+
+489
+00:34:40,830 --> 00:34:43,870
+بيأثر على ال polyploidy fertilization وبيأثر على
+
+490
+00:34:43,870 --> 00:34:47,730
+ال cleavage rate بيأثر على ال cleavage rate بهذا
+
+491
+00:34:47,730 --> 00:34:52,550
+الشكل نكون قد أنهينا من ال chapter هذا الشابتر
+
+492
+00:34:52,550 --> 00:34:56,110
+الشابتر الرابع على أمل أن نلتقي في شابتر جديد الشابتر
+
+493
+00:34:56,110 --> 00:34:59,970
+الجديد سوف نتحدث فيه عن كيف تتم عملية الحقن
+
+494
+00:34:59,970 --> 00:35:06,710
+process على أمل أن نلتقي دائما على خير دمتم في حفظ
+
+495
+00:35:06,710 --> 00:35:06,910
+الله
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/wi8cqG8vR_Q_postprocess.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/wi8cqG8vR_Q_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..0b56cc1e04332e0e5d20cb94e369e8adf9c64a2b
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/wi8cqG8vR_Q_postprocess.srt
@@ -0,0 +1,1980 @@
+1
+00:00:00,790 --> 00:00:04,650
+باسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:04,650 --> 00:00:10,210
+المرسلين سيدنا محمد وعلى آله وصحبه أجمعين اليوم
+
+3
+00:00:10,210 --> 00:00:14,230
+سوف نستكمل الجزء الأخير من هذا ال chapter والذي
+
+4
+00:00:14,230 --> 00:00:19,850
+سوف يتكلم بشكل أساسي عن ال culture media بمعنى ما
+
+5
+00:00:19,850 --> 00:00:24,350
+هي الأوساط التي يمكن أن تستخدم خلال عملية التلقيح
+
+6
+00:00:24,350 --> 00:00:28,980
+الصناعيما هي الأوساط التي يمكن أن تستخدم خلال نضوج
+
+7
+00:00:28,980 --> 00:00:33,800
+وانضاج البويضات خارج الرحم وما هي مكونات هذه
+
+8
+00:00:33,800 --> 00:00:39,080
+الأوساط وما هي الهدف الأساسي من استخدام هذه
+
+9
+00:00:39,080 --> 00:00:43,840
+المكونات ال culture media بشكل عام هي عبارة عن وسط
+
+10
+00:00:43,840 --> 00:00:48,360
+غذائي يشبه وسط الغذاء التي تكون متواجدة فيه
+
+11
+00:00:48,360 --> 00:00:52,400
+البويضة وتستخدم يا إما من أجل إنماء البويضة
+
+12
+00:00:52,610 --> 00:00:57,150
+واستكمال نموها إذا كانت في مرحة الـ M1 أو إبقائها
+
+13
+00:00:57,150 --> 00:01:02,350
+في وسط طبيعي يشبه الوسط الذي سوف تنتقل إليه وهو
+
+14
+00:01:02,350 --> 00:01:07,370
+عبارة عن رحم السيدة خلال عملية ال injection The
+
+15
+00:01:07,370 --> 00:01:11,390
+optimal cultural media which reflect the changing
+
+16
+00:01:11,390 --> 00:01:17,770
+need of the developed embryo is important for
+
+17
+00:01:17,770 --> 00:01:23,260
+success of IVF treatmentيعني بمعنى آخر كل ما كانت
+
+18
+00:01:23,260 --> 00:01:29,880
+الوسط الزراعي أو ال media قريبة من الوسط التي يوجد
+
+19
+00:01:29,880 --> 00:01:35,080
+فيه ال embryo أو توجد فيه البويضة كل ما زاد فرصة
+
+20
+00:01:35,080 --> 00:01:39,040
+نجاح عملية التلقيح أو عملية الحقن المجاني ال
+
+21
+00:01:39,040 --> 00:01:44,660
+environment بتلعب دور مهم جداالضغط الشديد اللى
+
+22
+00:01:44,660 --> 00:01:48,160
+بتتعرضلها الخلية بتتعرضل الـ oocyte من oxidative
+
+23
+00:01:48,160 --> 00:01:52,200
+stress من pH من كمية البومين من كمية البروتين من
+
+24
+00:01:52,200 --> 00:01:56,280
+كمية الجلوكوز من كمية البيروفيت يجب أن تشبه إلى حد
+
+25
+00:01:56,280 --> 00:02:00,480
+ما الكمية اللى بتتعرضلها و هي في ال ovary و هي في
+
+26
+00:02:00,480 --> 00:02:05,580
+ال uterus و هي كمان في ال fallopian tube فمش هيكون
+
+27
+00:02:05,580 --> 00:02:10,760
+هناك اختلاف لضمان نجاح عملية الحقن المجهري سواء
+
+28
+00:02:10,760 --> 00:02:15,370
+كانت البويضةفي مرحلة بويضة أو في مرحلة زيجوت أو في
+
+29
+00:02:15,370 --> 00:02:19,070
+مرحلة الامبريو في كل مرحلة من المراحل بيكون
+
+30
+00:02:19,070 --> 00:02:23,330
+حواليها وسط غذائي في داخل جسم السيدة خاص فيها
+
+31
+00:02:23,330 --> 00:02:27,070
+يختلف عن الوسط اللي بيكون في الزيجوت أو يختلف عن
+
+32
+00:02:27,070 --> 00:02:30,630
+الوسط اللي بيكون في الامبريو فبالتالي لازم اوفر
+
+33
+00:02:30,630 --> 00:02:35,590
+وسط غذائي في المعمل يشبه الوسط الغذائي اللي بيكون
+
+34
+00:02:35,590 --> 00:02:38,650
+في الامبريو اللي بتكون فيها البويضة و اللي بيكون
+
+35
+00:02:38,650 --> 00:02:42,450
+فيها البويضة خلال انتقالها في ال fallopian tubeThe
+
+36
+00:02:42,450 --> 00:02:46,610
+culture media need to meet the metabolic need of
+
+37
+00:02:46,610 --> 00:02:52,450
+pre-implantation embryo by addressing genetic and
+
+38
+00:02:52,450 --> 00:02:55,830
+amino acid requirement in stage specific manner
+
+39
+00:02:55,830 --> 00:03:00,410
+بمعنى أخر أن مرحلة البويضة تحتاج إلى كمية من ال
+
+40
+00:03:00,410 --> 00:03:04,350
+amino acid تختلف عن المرحلة الجنينية تختلف عن
+
+41
+00:03:04,350 --> 00:03:08,750
+مرحلة الزيجوت فبالتالي لكل مرحلة احتياجاتها لازم
+
+42
+00:03:08,750 --> 00:03:11,330
+أعرف أنا هذه الاحتياجات وأوفرها في ال culture
+
+43
+00:03:11,330 --> 00:03:14,810
+mediaأول ما تم اكتشاف الـ Culture Media أو الـ
+
+44
+00:03:14,810 --> 00:03:20,850
+Media الخاصة بالـ IVF كان في عام 1980 في عام 1985
+
+45
+00:03:20,850 --> 00:03:25,170
+كان أول Media يصرح باستخدامها وكان يطلق عليها الـ
+
+46
+00:03:25,170 --> 00:03:32,390
+HITF بمعنى Human Tupule Fluid وهي تشبه إلى حد ال
+
+47
+00:03:32,390 --> 00:03:36,190
+Mediaإلى حد كبير جدا ال media الموجودة in vivo
+
+48
+00:03:36,190 --> 00:03:40,230
+environment to which the embryo is exposed يعني
+
+49
+00:03:40,230 --> 00:03:44,610
+تشبه بشكل كبير جدا ال media الداخلية التي يتعرض
+
+50
+00:03:44,610 --> 00:03:48,310
+إليها ال embryo خلال عملية انتقاله من ال fallopian
+
+51
+00:03:48,310 --> 00:03:52,870
+tube إلى الرحم الهدف الأساسي من ال culture media
+
+52
+00:03:52,870 --> 00:03:56,610
+أو ال embryo culture as a part of human assisted
+
+53
+00:03:56,610 --> 00:04:00,230
+reproduction is to provide a stable environment
+
+54
+00:04:00,230 --> 00:04:04,760
+for embryo to growand develop from fertilization
+
+55
+00:04:04,760 --> 00:04:10,160
+through the early stage for transfer into the
+
+56
+00:04:10,160 --> 00:04:14,020
+uterus or cryopreservation يعني بمعنى بسيط جدا
+
+57
+00:04:14,020 --> 00:04:17,520
+الهدف الأساسي من ال embryonic media أو ال embryo
+
+58
+00:04:17,520 --> 00:04:22,280
+media هي توفير ظروف مناخية تناسب الجنين في كل
+
+59
+00:04:22,280 --> 00:04:26,260
+مراحله في المراحل أثناء انتقاله من fallopian tube
+
+60
+00:04:26,720 --> 00:04:29,500
+في المراحل التي ينغرس فيها في بطانة الرحم في
+
+61
+00:04:29,500 --> 00:04:33,440
+المراحل التي تؤهله لعملية الـ Cryopreservation أي
+
+62
+00:04:33,440 --> 00:04:38,320
+التجميد باستخدام الـ Liquid Nitrogen فعلى سبيل
+
+63
+00:04:38,320 --> 00:04:42,900
+المثال، في ميديا تستخدم في الـ cleavage stage في
+
+64
+00:04:42,900 --> 00:04:46,360
+اليوم التاني والتالت شو يعني الـ cleavage stage؟
+
+65
+00:04:46,360 --> 00:04:51,360
+شو يعني اليوم التاني والتالت؟ ببساطة جدا، البويضة
+
+66
+00:04:51,360 --> 00:04:55,560
+بعد إخصابها بتمر بخمس أيام كل يوم بيصير فيها
+
+67
+00:04:55,560 --> 00:04:58,920
+انقسامانقسام اليوم الأول وانقسام اليوم التاني
+
+68
+00:04:58,920 --> 00:05:02,080
+وانقسام اليوم التالت وانقسام اليوم الرابع وانقسام
+
+69
+00:05:02,080 --> 00:05:06,500
+اليوم الخامس هذه كل يوم عبارة عن انقسام وفي كل يوم
+
+70
+00:05:06,500 --> 00:05:11,160
+تنتقل من مكان وفي كل يوم تنتقل من مكان إلى مكان
+
+71
+00:05:11,160 --> 00:05:16,620
+آخر خلال عملية الانتقال من Fallopian tube إلى
+
+72
+00:05:16,620 --> 00:05:22,020
+بيطانة الرحم ثم الانغراس فبالتالي احتياجته في
+
+73
+00:05:22,020 --> 00:05:25,520
+اليوم الأولللمادة الغذائية تختلف عن اليوم التاني،
+
+74
+00:05:25,520 --> 00:05:28,300
+تختلف عن التالت، تختلف عن الرابع، تختلف عن الخامس
+
+75
+00:05:28,300 --> 00:05:32,320
+و هكذا، فلازم كل يوم أعرف شو هو اليوم و شو هو
+
+76
+00:05:32,320 --> 00:05:35,560
+الاحتياجات فالcleavage stage for example دي اتنين
+
+77
+00:05:35,560 --> 00:05:41,240
+لديه تلاتة it has become clear that it isprefer to
+
+78
+00:05:41,240 --> 00:05:46,420
+transfer at the plastocyst stage day 5 or day 6
+
+79
+00:05:46,420 --> 00:05:50,160
+for the number of reasons شو يعني plastocyst؟ شو
+
+80
+00:05:50,160 --> 00:05:53,860
+يعني morella؟ هي عبارة عن مرحلة من مراحل تطور
+
+81
+00:05:53,860 --> 00:05:58,920
+الجنين، هناخدها باستفادة، سي goat, plastocyst,
+
+82
+00:05:59,840 --> 00:06:03,300
+morella، أسماء كتيرة هنتكلم عنها، بس احنا مش
+
+83
+00:06:03,300 --> 00:06:07,460
+هنستفيد في الحتة هذه، في اللحظة هذهفي عند عزبين
+
+84
+00:06:07,460 --> 00:06:12,100
+المثال spontaneous conception لـ human embryo does
+
+85
+00:06:12,100 --> 00:06:16,500
+not normally pass into the uterus until morella في
+
+86
+00:06:16,500 --> 00:06:20,220
+التلقيح الطبيعي وعملية التلقيح الطبيعية الـ
+
+87
+00:06:20,220 --> 00:06:26,320
+intercourses ال embryo ما بينتقل إلى الرحم إلا إذا
+
+88
+00:06:26,320 --> 00:06:29,900
+وصل لمرحلة الموريلا والموريلا هي عبارة عن خلية
+
+89
+00:06:29,900 --> 00:06:34,650
+تحتوي بداخلها على أكتر من 32 خليةهذا تعريف البسيط
+
+90
+00:06:34,650 --> 00:06:37,870
+خلّينا نعرفها بهذا الشكل حتى الآن و قدام هناخد
+
+91
+00:06:37,870 --> 00:06:41,970
+استفادة شوية عن موريلا to the early plastocyst
+
+92
+00:06:41,970 --> 00:06:46,830
+stage and the aortas is like not well occupied to
+
+93
+00:06:46,830 --> 00:06:50,830
+support the cleavage stage embryo يعني بيقول لي
+
+94
+00:06:50,830 --> 00:06:55,970
+ببساطة جدا أنه في الوضع الطبيعي و التلقيح الطبيعي
+
+95
+00:06:55,970 --> 00:07:02,510
+ال embryo لن ينتقل إلى الرحم إلا بعد أن تتحول
+
+96
+00:07:02,510 --> 00:07:08,160
+لموريلاوهي أحد أطوار الجنين إلى Plastocyst والـ
+
+97
+00:07:08,160 --> 00:07:13,980
+Plastocyst أكتر من 64 خلية ببساطة يعني إذا كان
+
+98
+00:07:13,980 --> 00:07:17,440
+موريلا معناه لسه مش هينزل إلى الرحم، هيظل في الـ
+
+99
+00:07:17,440 --> 00:07:21,580
+Fallopian tube وين انتقل لمرحلة Plastocyst؟ هينتقل
+
+100
+00:07:21,580 --> 00:07:26,980
+إلى الـ Uterus ويصيرله Implantationواخدوا بالك
+
+101
+00:07:26,980 --> 00:07:30,420
+طالما موريلا إلا إحتياجاتها طالما Plastocyst إلا
+
+102
+00:07:30,420 --> 00:07:34,420
+إحتياجات مختلفة الـ gonadotropin stimulation of
+
+103
+00:07:34,420 --> 00:07:38,400
+the ovary to provide an increased number of oocyte
+
+104
+00:07:38,400 --> 00:07:42,720
+result is very high circulating concentration of
+
+105
+00:07:42,720 --> 00:07:47,420
+estrogen that led to abnormal development and
+
+106
+00:07:47,420 --> 00:07:50,820
+functional activity of uterus خلال عملية تحفيز
+
+107
+00:07:50,820 --> 00:07:54,220
+المبيض الزوجة والسيدة بتاخد كمية كبيرة جدا من
+
+108
+00:07:54,220 --> 00:07:58,740
+الهرموناتهذه الهرمونات تعمل خربة خلّينا نسميها عدم
+
+109
+00:07:58,740 --> 00:08:04,780
+انتظام في الحالة العامة للسيدة في الدورة الدموية
+
+110
+00:08:04,780 --> 00:08:09,460
+للسيدة في عملية .. العمليات التي تحدث في ال
+
+111
+00:08:09,460 --> 00:08:12,960
+reproductive system نسبة إلى وجود كمية كبيرة جدا و
+
+112
+00:08:12,960 --> 00:08:16,180
+تركيز كبير وعالي من الاستروجين في الدورة الدموية
+
+113
+00:08:16,180 --> 00:08:19,800
+هذا ممكن يعمل abnormality في development of
+
+114
+00:08:19,800 --> 00:08:23,400
+unfunctional activity of uterus يعني بمعنى أخر
+
+115
+00:08:23,750 --> 00:08:28,110
+الرحم ما بيعمل بالطريقة المطلوبة في هذه اللحظة سبب
+
+116
+00:08:28,110 --> 00:08:32,550
+التالت بعض الأحيان بيقول ال culture to plastocyst
+
+117
+00:08:32,550 --> 00:08:38,550
+stage allowed for more extensive evaluation of the
+
+118
+00:08:38,550 --> 00:08:44,550
+embryo خاصة بال genetic testing أنا لما أجي أخلي
+
+119
+00:08:44,550 --> 00:08:48,250
+ال embryo في media ليوم أو يومين قبل عملية الإرجاع
+
+120
+00:08:48,250 --> 00:08:51,610
+هذا بتحلي فرصة أن أعمل selection شو يعني
+
+121
+00:08:51,610 --> 00:08:55,570
+selection؟أرجع على سبيل المثال الجنين السليم الذي
+
+122
+00:08:55,570 --> 00:08:59,430
+لا يحتوي على أمراض غيراثية أو أرجع الجنين الذكر أو
+
+123
+00:08:59,430 --> 00:09:03,370
+أرجع الجنين الأنثى يعني بتيح لفترة زمانية كافية أن
+
+124
+00:09:03,370 --> 00:09:08,210
+أعمل فحوصات جينية على الجنين قبل الإرجاع مما يضمن
+
+125
+00:09:08,210 --> 00:09:12,830
+ليه بشكل كبير إلى حد ما إرجاع الجنين المطلوب أو
+
+126
+00:09:12,830 --> 00:09:17,440
+الجنين السليمفي هندى من أشهر أنواع ال media اللى
+
+127
+00:09:17,440 --> 00:09:20,420
+استخدمت هي ال tissue culture media ال tissue
+
+128
+00:09:20,420 --> 00:09:24,000
+culture media من أشهر هذه ال media اللى استخدمت
+
+129
+00:09:24,000 --> 00:09:27,620
+وكانت تحتوي solution salt solution بيحتوى على
+
+130
+00:09:27,620 --> 00:09:29,480
+Sodium chloride, potassium chloride, calcium
+
+131
+00:09:29,480 --> 00:09:33,540
+chloride و low concentration of sodium bicarbonate
+
+132
+00:09:33,540 --> 00:09:37,860
+عشان تعمل ال balance في ال pH وهذه طبعا إلى حد ما
+
+133
+00:09:37,860 --> 00:09:43,720
+استخدمت بكمية كبيرة جدا for the study of the frog
+
+134
+00:09:43,720 --> 00:09:49,270
+heartنبضات قلب الضفدع و كانوا يستخدموها .. طبعا
+
+135
+00:09:49,270 --> 00:09:52,870
+كانوا زمان يستخلصوا و ينزعوا قلب الضفدع و يضيفوا
+
+136
+00:09:52,870 --> 00:09:56,030
+عليه ال ringer solution اللي هو عبارة عن Sodium
+
+137
+00:09:56,030 --> 00:09:58,350
+Chloride أو Potassium Chloride أو whatever و يشوف
+
+138
+00:09:58,350 --> 00:10:02,210
+هل هو باستجيب لهذه الأملح بقداش كمية استجابته فهم
+
+139
+00:10:02,210 --> 00:10:07,150
+بدوا يستخدموا هذه ال media إلى ال IVF أو لل IVF
+
+140
+00:10:07,150 --> 00:10:11,230
+بعدها أثبت كفاوب و لكن بعد كده تم تطوير الأمر بشكل
+
+141
+00:10:11,230 --> 00:10:14,930
+كبير جدا حاليا في عند media كاملة و media جاهزة
+
+142
+00:10:15,110 --> 00:10:18,650
+تستخدم بكفاءة عالية جدا إيش موجود في ال media؟
+
+143
+00:10:18,650 --> 00:10:21,270
+وإيش ال reagent اللي موجود؟ في عندي media بيسميها
+
+144
+00:10:21,270 --> 00:10:24,650
+cleavage media وفي media بيسميها plastocyst media
+
+145
+00:10:24,650 --> 00:10:28,510
+من اسمة cleavage media يعني media .. mediaة
+
+146
+00:10:28,510 --> 00:10:32,830
+الإنقسام الوسط الغذائي للإنقسام وهو يستخدم في
+
+147
+00:10:32,830 --> 00:10:36,870
+اليوم الأول والتاني والتالت من الحقن يعني لو أنا
+
+148
+00:10:36,870 --> 00:10:39,950
+حقنت ال boiler يوم السبت هستخدم ال cleavage media
+
+149
+00:10:39,950 --> 00:10:43,910
+يوم السبت والأحد والإتنينبلاستوست ميديا التلاتة
+
+150
+00:10:43,910 --> 00:10:47,470
+والاربعة ليش التلاتة والاربعة؟ أو ليش خمس أيام؟
+
+151
+00:10:47,470 --> 00:10:52,170
+لأن عملية الإرجع تحدث في اليوم التالت أو الرابع أو
+
+152
+00:10:52,170 --> 00:10:55,230
+الخامس في الدول المتقدمة في راجعه في الخامس فإن
+
+153
+00:10:55,230 --> 00:11:00,090
+بيراجعه في التالت أو الرابع كحد أقصى فيه طبعا في
+
+154
+00:11:00,090 --> 00:11:04,290
+ال media reagent منها اللي هي lorandaise serum
+
+155
+00:11:04,290 --> 00:11:08,490
+sperm preparation media هذه أنواع الميديا التي
+
+156
+00:11:08,490 --> 00:11:13,540
+تستخدم خلال الحقنفي عند الـ Hyaluronidase Media في
+
+157
+00:11:13,540 --> 00:11:15,960
+عند الـ Sperm Preparation Media وفي عند الـ PVP
+
+158
+00:11:15,960 --> 00:11:19,940
+Media يعني في أنا عندي أربع أنواع من ال media أو
+
+159
+00:11:19,940 --> 00:11:23,520
+أربع أنواع من ال reagent تستخدم بشكل كامل culture
+
+160
+00:11:23,520 --> 00:11:27,260
+media خاصة بالـ oocyte و ال embryo أفضل مثال عليها
+
+161
+00:11:27,260 --> 00:11:31,600
+ال cleavage media و ال blastocyst media cleavage
+
+162
+00:11:31,600 --> 00:11:33,780
+media في اليوم الأول و التالت و ال blastocyst في
+
+163
+00:11:33,780 --> 00:11:36,320
+اليوم الرابع و الخامس في ال media اسمها الـ
+
+164
+00:11:36,320 --> 00:11:39,160
+Hyaluronidase اللي استخدمناها في ال cumulus
+
+165
+00:11:39,160 --> 00:11:42,600
+removing ال strippingفي عند الـ sperm preparation
+
+166
+00:11:42,600 --> 00:11:46,120
+media وهذا هنستخدمها في الـ chapter اللي جاي علشان
+
+167
+00:11:46,120 --> 00:11:50,700
+أنا أحصل على single sperm صالح لل injection وفي
+
+168
+00:11:50,700 --> 00:11:55,060
+عند ال BVB media طبعا هذه ال BVB media هي عبارة عن
+
+169
+00:11:55,060 --> 00:11:59,120
+intracytoplasmic sperm injection media أو في بعض
+
+170
+00:11:59,120 --> 00:12:02,620
+الأحيان بيسموها media used during injection طبعا
+
+171
+00:12:02,620 --> 00:12:06,280
+مهمة جدا هذه ال media ووظيفتها إنها بتقلل قدرة ال
+
+172
+00:12:06,280 --> 00:12:09,220
+sperm على ال motility يعني بتعمل reduction in the
+
+173
+00:12:09,220 --> 00:12:13,030
+motility of spermatozoaتعمل prevent their sticking
+
+174
+00:12:13,030 --> 00:12:18,650
+to the injection pipet بمعنى آخر إن ال sperm قدرته
+
+175
+00:12:18,650 --> 00:12:21,350
+على الموتلتي بتقل يعني أنا بقدر أتحكم بال sperm و
+
+176
+00:12:21,350 --> 00:12:25,350
+أعمله catching أيضا تمنع اتصاق ال sperm بالجدار
+
+177
+00:12:25,350 --> 00:12:31,250
+الداخلي لل tube فبالتالي أنا ال sperm بقدر أشوف هو
+
+178
+00:12:31,250 --> 00:12:37,030
+بتحرك داخل ال tube خلال عملية الإنزال والسحبDuring
+
+179
+00:12:37,030 --> 00:12:40,610
+the procedure and to give more control over the
+
+180
+00:12:40,610 --> 00:12:44,970
+flow of a fluid in the XZ needle أيضًا بتعطيني
+
+181
+00:12:44,970 --> 00:12:49,010
+قدرة كبيرة جدًا على التحكم بالسائل أثناء دخوله
+
+182
+00:12:49,010 --> 00:12:52,710
+وخروجه من ال injection needle إبرة تلحقت عشان
+
+183
+00:12:52,710 --> 00:12:59,330
+كثافتها، الكثافة تبعتها كافية لإحداث تحكم واضح من
+
+184
+00:12:59,330 --> 00:13:02,170
+ال reagent اللي يستخدم إضافة إلى ال culture media
+
+185
+00:13:02,170 --> 00:13:06,020
+اللي هي الورينبيز وال C-Spermpreparation media و
+
+186
+00:13:06,020 --> 00:13:10,020
+ال PVP في ال oil طبعا انا بستخدم ال oil بشكل كبير
+
+187
+00:13:10,020 --> 00:13:14,560
+جدا عشان اغطي ال media لما انا بتردش اضيف قطرة
+
+188
+00:13:14,560 --> 00:13:17,320
+drop .. drop .. drop .. drop من ال media لازم
+
+189
+00:13:17,320 --> 00:13:22,000
+اغطيها ب oil هذا ال oil بيحمي ال media و بيحمي
+
+190
+00:13:22,000 --> 00:13:25,340
+البويضة اللي موجودة داخل ال media او بيحمي ال
+
+191
+00:13:25,340 --> 00:13:28,280
+embryo اللي موجود داخل ال media من ال external
+
+192
+00:13:28,280 --> 00:13:32,480
+environment factor فبيعطيها كمية حرارة ثابتة
+
+193
+00:13:32,480 --> 00:13:37,450
+cosmolarity ثابتةبـH ثابتة، humidity ثابتة مافي
+
+194
+00:13:37,450 --> 00:13:42,210
+fluctuation، تزحزح، تغير، عدم ثبات والـ oil
+
+195
+00:13:42,210 --> 00:13:46,830
+بيعمللي نوع من أنواع ال sterilization هائل جدا ده
+
+196
+00:13:46,830 --> 00:13:50,690
+ال quality of oil can be affected by shipping طبعا
+
+197
+00:13:50,690 --> 00:13:53,910
+أكيد بتأثر بال shipping، بال storage، ال light
+
+198
+00:13:53,910 --> 00:14:00,270
+فبالتالي لازم ال oil يتم شرائه من مكان موثوق فيه
+
+199
+00:14:00,270 --> 00:14:04,450
+خاص بال IPF مش أي oil يستخدمThe oil type commonly
+
+200
+00:14:04,450 --> 00:14:09,210
+used are mineral oil و paraffin oil و بعض الأحيان
+
+201
+00:14:09,210 --> 00:14:13,270
+الناس بتخلق mineral مقرفين يعني هذا أفضل ال oil
+
+202
+00:14:13,270 --> 00:14:17,010
+مستخدم ال human serum albumin يعتبر من المواد التي
+
+203
+00:14:17,010 --> 00:14:21,930
+تستخدم وتوجد في ال media بكمية معينة و بدرجة معينة
+
+204
+00:14:21,930 --> 00:14:25,570
+جدا السبب استخدامه لأنه بلعب على التوتر السطحي
+
+205
+00:14:25,570 --> 00:14:29,670
+بلعب على عامل التوتر السطحي كيف بيعمل و إيش وظيفته
+
+206
+00:14:30,020 --> 00:14:33,200
+بعمل preventing embryo and gamete from sticking
+
+207
+00:14:33,200 --> 00:14:41,440
+the inner surface of the tube يعني بمعنى آخر بعمل
+
+208
+00:14:41,440 --> 00:14:45,820
+منع لالتصاق ال embryo أو الجاميطات سواء كانت ال
+
+209
+00:14:45,820 --> 00:14:49,520
+oocyte أو ال sperm أن تلتصق بالجدار الداخلي خلال
+
+210
+00:14:49,520 --> 00:14:53,200
+عملية ال injection مش منطق أنا أجي أعمل injection
+
+211
+00:14:53,200 --> 00:14:55,860
+ولاجي ال sperm مملزج في الجدار الداخلي لل
+
+212
+00:14:55,860 --> 00:15:01,140
+injection needle مش راضي ينزل خطأأنا عملت pools
+
+213
+00:15:01,140 --> 00:15:05,920
+فاشل injection فاشل فلازم يكون فيه هندي human
+
+214
+00:15:05,920 --> 00:15:11,320
+serum albumin علشان يقلل ال sticking ال attachment
+
+215
+00:15:11,320 --> 00:15:14,620
+with the inner surface of injection needle
+
+216
+00:15:14,620 --> 00:15:19,020
+additionally albumin can protect embryo from toxic
+
+217
+00:15:19,020 --> 00:15:22,500
+substance in the culture environment and act as
+
+218
+00:15:22,500 --> 00:15:26,240
+buffer مهم جدا أن يحمل embryo من أي toxic material
+
+219
+00:15:26,240 --> 00:15:32,650
+وبيلعب ك bufferفي إمبريو بعد تطور الأحداث و تطور
+
+220
+00:15:32,650 --> 00:15:36,270
+الدراسات صار في عندي إمبريو جديد اسمه sequential
+
+221
+00:15:36,270 --> 00:15:40,810
+إمبريو يعني التدريجية أو التتابعية الـ early
+
+222
+00:15:40,810 --> 00:15:45,510
+culture media used in human IVF tend to be rather
+
+223
+00:15:45,510 --> 00:15:49,010
+simply very simple تحتوي على بعض السلط
+
+224
+00:15:49,010 --> 00:15:52,930
+والهيدروكربونيات والهيدروكربونيات يعني أول ما تم
+
+225
+00:15:52,930 --> 00:15:56,430
+إنشاء الميديا كانت بسيطة جدا water, sterile water,
+
+226
+00:15:56,550 --> 00:15:59,830
+sterile water, ultra pure waterفيها كمية من
+
+227
+00:15:59,830 --> 00:16:03,630
+الأملاح و فيها carbohydrate طيب بعد كده اتغير
+
+228
+00:16:03,630 --> 00:16:07,090
+الموضوع صاروا يضيفوا او يستخدموا ال media الخاصة
+
+229
+00:16:07,090 --> 00:16:11,630
+بال tissue culture و أعطت كفاءة كافية و كفاءة و
+
+230
+00:16:11,630 --> 00:16:17,670
+نتائج معينة بعد كده اتطور الموضوع فصار يدمجوا بعض
+
+231
+00:16:17,670 --> 00:16:20,970
+الأنواع المختلفة من ال media مع بعض البعض فصار في
+
+232
+00:16:20,970 --> 00:16:25,970
+عندي simple media those lead amino acid such as
+
+233
+00:16:25,970 --> 00:16:31,310
+those develop initial form mouseand adapted for
+
+234
+00:16:31,310 --> 00:16:34,930
+the human يعني أول أنواع ال simple media هي عبارة
+
+235
+00:16:34,930 --> 00:16:38,570
+عن ال simple media التي تفتقر إلى بعض أنواع من
+
+236
+00:16:38,570 --> 00:16:41,710
+الأحماض الأمنية كانوا يستخدموها في البداية علشان
+
+237
+00:16:41,710 --> 00:16:45,530
+ال ember الخاص بال mouse و يستخدموها مع ال human
+
+238
+00:16:45,530 --> 00:16:49,930
+أعطت نتاج أعطت نتاج مين مثال عليها؟ مثال عليها ال
+
+239
+00:16:49,930 --> 00:16:56,230
+human tubule fluid media ولكن we're not effective
+
+240
+00:16:56,570 --> 00:17:00,110
+in supporting a human embryo past itself صحيح أنها
+
+241
+00:17:00,110 --> 00:17:02,990
+أعطت نتائج في البدايات ولكن لما نيصل ال embryo إلى
+
+242
+00:17:02,990 --> 00:17:07,610
+8 خلايا مافي إلى أهمية مافي إلى أي قيمة فبالتالي
+
+243
+00:17:07,610 --> 00:17:12,150
+أثبتت فشلها مع ال embryo related with the human
+
+244
+00:17:12,150 --> 00:17:18,210
+عندما يصل إلى 8 خلايا فاستخدموا sequential median
+
+245
+00:17:18,210 --> 00:17:23,950
+بمعنى آخر في آخرعشر إلى خمس عشر سنة صار في عندي
+
+246
+00:17:23,950 --> 00:17:28,030
+shifting بشكل دراماتيكي في تطور ال media فأصبح
+
+247
+00:17:28,030 --> 00:17:33,790
+يستخدم media للcleavage و للplastocyst و لل embryo
+
+248
+00:17:33,790 --> 00:17:36,850
+يعني تلتة في واحد يعني هذه ال media تصلح لجميع
+
+249
+00:17:36,850 --> 00:17:42,030
+المراحل تطور الجنين so the stage of cleavage و
+
+250
+00:17:42,030 --> 00:17:44,850
+stage of embryo are cultured in one media
+
+251
+00:17:44,850 --> 00:17:49,320
+formation of the first one to three daysthen
+
+252
+00:17:49,320 --> 00:17:53,280
+subsequently placed into a second media formation
+
+253
+00:17:53,280 --> 00:17:56,320
+for the next two to three days to support Morella
+
+254
+00:17:56,320 --> 00:18:00,960
+and Plastocyst development يعني في .. في .. في ..
+
+255
+00:18:00,960 --> 00:18:05,380
+بمعنى آخر قبل ما يصير تطور للميديا و يصير dramatic
+
+256
+00:18:05,380 --> 00:18:09,040
+shifting بشكل واضح كانوا يستخدموا ميديا لأول تلت
+
+257
+00:18:09,040 --> 00:18:12,980
+أيام بعدين ينقلوا الجنين و يضيفوا ميديا تانية
+
+258
+00:18:12,980 --> 00:18:16,620
+لليوم الرابع والخامس ال media الأولى مسئولة عن ال
+
+259
+00:18:16,620 --> 00:18:21,810
+developmentوالميديا التانية مسؤولة عن تدعيم نمو
+
+260
+00:18:21,810 --> 00:18:27,190
+الموريلا والبلاستوسيست هذه الميديا قليلًا في
+
+261
+00:18:27,190 --> 00:18:30,990
+مجموعتهم تغيير مستوى الجليكوز ومجموعات الطاقة
+
+262
+00:18:30,990 --> 00:18:35,270
+الأخرى كذلك في تغيير المزيد من المزيد من المزيد من
+
+263
+00:18:35,270 --> 00:18:36,010
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+264
+00:18:36,010 --> 00:18:36,490
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+265
+00:18:36,490 --> 00:18:38,490
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+266
+00:18:38,490 --> 00:18:41,310
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+267
+00:18:41,310 --> 00:18:41,610
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+268
+00:18:41,610 --> 00:18:43,730
+المزيد من المزيد من المزيد من المزيد من المزيد من
+
+269
+00:18:43,730 --> 00:18:47,680
+المزيد من المزيد من المبالإضافة إلى كمية الـ
+
+270
+00:18:47,680 --> 00:18:51,820
+substrate اللي بتاعة الطاقة أضف إلى ذلك أنواع
+
+271
+00:18:51,820 --> 00:18:56,340
+الأحماض الأمينية هذا الاختلاف البسيط ما بينهم صورة
+
+272
+00:18:56,340 --> 00:19:01,020
+بتوضحلي شو يعني ال common integrity اللي موجودة في
+
+273
+00:19:01,020 --> 00:19:05,640
+ال sequential culture system في عند اليوم الأول و
+
+274
+00:19:05,640 --> 00:19:09,640
+اليوم التاني و اليوم التالتو اليوم الرابع و اليوم
+
+275
+00:19:09,640 --> 00:19:12,440
+الخامس و اليوم السادس هذه عبارة عن أيام الإنقسام
+
+276
+00:19:12,440 --> 00:19:16,560
+الستة في ناس بترجع في اليوم التالت أو بعد عفوًا
+
+277
+00:19:16,560 --> 00:19:21,580
+اليوم التالت و في ناس بترجع في اليوم الرابع أو
+
+278
+00:19:21,580 --> 00:19:28,160
+الخامس أو السادس بناءً على كفاءة الجنين وجودته الـ
+
+279
+00:19:28,160 --> 00:19:32,800
+sequential media هي عبارة عن media جزء منها أو هي
+
+280
+00:19:32,800 --> 00:19:36,930
+عبارة عن media تتكون من two partsالـ Part الأول أو
+
+281
+00:19:36,930 --> 00:19:40,770
+الـ Vial الأول يستخدم من اليوم الأول للتالت والـ
+
+282
+00:19:40,770 --> 00:19:44,670
+Vial التاني يستخدم من اليوم الرابع للخامس يحتوي
+
+283
+00:19:44,670 --> 00:19:48,710
+على نفس المواد ولكن بتركيز مختلفة هذا بنتسميه
+
+284
+00:19:48,710 --> 00:19:52,390
+Sequential Media التي تستخدم في اليوم الأول للتالت
+
+285
+00:19:52,390 --> 00:19:57,450
+تحتوي على كمية قليل جدا من الجريكوز فيها إيديتا
+
+286
+00:19:57,450 --> 00:20:00,290
+فيها بيروفيت فيها لاكتيت وما فيها essential amino
+
+287
+00:20:00,290 --> 00:20:04,500
+acidالتي تستخدم من اليوم الرابع للسادس فيها
+
+288
+00:20:04,500 --> 00:20:09,540
+essential amino acid فيها كمية واثيرة من الجليكوز
+
+289
+00:20:09,540 --> 00:20:13,960
+فيها بيروفيت و فيها لاكتيت أضف إلى ذلك no
+
+290
+00:20:13,960 --> 00:20:17,680
+essential amino acid no essential amino acid أو
+
+291
+00:20:17,680 --> 00:20:19,980
+fine non essential amino acid مش موجود عفوا فيها
+
+292
+00:20:19,980 --> 00:20:22,700
+non essential amino acid يعني بمعنى أخر non
+
+293
+00:20:22,700 --> 00:20:25,800
+essential amino acid موجود في البارت الأول موجود
+
+294
+00:20:25,800 --> 00:20:29,330
+في البارت التانيالجليكوز موجود في ال part الأول
+
+295
+00:20:29,330 --> 00:20:32,490
+بكمية قليلة في ال part التاني بكمية أعلى ال bio
+
+296
+00:20:32,490 --> 00:20:35,530
+rate موجود في كلاهما ال lactate موجود في كلاهما ال
+
+297
+00:20:35,530 --> 00:20:38,970
+Edita موجودة في ال part الأول مش موجودة في ال part
+
+298
+00:20:38,970 --> 00:20:42,190
+التاني و ال part التاني يختلف عن ال part الأول في
+
+299
+00:20:42,190 --> 00:20:45,250
+وجود ال essential amino acid في وجود ال essential
+
+300
+00:20:45,250 --> 00:20:48,630
+amino acid هذه بيسموها sequential cultural media
+
+301
+00:20:48,630 --> 00:20:51,470
+هي عبارة عن ميديا بتكوين من two files ال file
+
+302
+00:20:51,470 --> 00:20:54,320
+الأول لأول تلت أيام و الفعل التاني لتلت أياملتالي
+
+303
+00:20:54,320 --> 00:20:57,440
+تلت أيام و هو الرابع و الخمسة و السادس او الرابع و
+
+304
+00:20:57,440 --> 00:21:00,900
+الخمس و السادس استقدروا هذا الموضوع ب one media
+
+305
+00:21:00,900 --> 00:21:05,660
+وهي media يمكن ان تستخدم من اليوم الأول لليوم
+
+306
+00:21:05,660 --> 00:21:10,220
+السادس فيها non-essential فيها essential فيها
+
+307
+00:21:10,220 --> 00:21:13,820
+edita فيها jericose فيها pyruvate و فيها lactate
+
+308
+00:21:13,820 --> 00:21:18,280
+يعني كأنه بيقولك تحتوي على جميع المواد و اللي عاوز
+
+309
+00:21:18,280 --> 00:21:22,200
+الجنين ياخدهاللي عاوزة الموريلا من المواد تاخدها
+
+310
+00:21:22,200 --> 00:21:26,860
+عاوزة بلاستوست مواد معينة تاخدها الزيجوت عاوزة من
+
+311
+00:21:26,860 --> 00:21:30,500
+المواد معينة تاخدها والمواد التانية مايلها side
+
+312
+00:21:30,500 --> 00:21:35,460
+effect عليها أشهر المواد الموجودة الجليكوز الذي
+
+313
+00:21:35,460 --> 00:21:40,120
+يعتبر أشهر وأكبر مادة موجودة في ال culture media
+
+314
+00:21:40,120 --> 00:21:46,070
+الجنين بيحتاجهand is one of the primary variable
+
+315
+00:21:46,070 --> 00:21:49,310
+in sequential media culture media أكيد لأنه قولنا
+
+316
+00:21:49,310 --> 00:21:53,890
+الفي ال very low في step one أو ال vial one و very
+
+317
+00:21:53,890 --> 00:21:57,010
+high في ال vial two طبعا ال cleavage stage human
+
+318
+00:21:57,010 --> 00:22:03,050
+embryo can be used glucose ولكن بكميات قليلة بيزيد
+
+319
+00:22:03,050 --> 00:22:07,170
+كل ما زاد عمر الجنين ال lactate و ال pyruvate the
+
+320
+00:22:07,170 --> 00:22:11,480
+additionof lactate to early salt solution media
+
+321
+00:22:11,480 --> 00:22:16,320
+was instrumental in supporting development from
+
+322
+00:22:16,320 --> 00:22:19,380
+the two cell stage of the mouse embryo وجدوا إن
+
+323
+00:22:19,380 --> 00:22:25,060
+اللاكتات يستخدم بشكل كبير جدا في تدعيم نمو الخلايا
+
+324
+00:22:25,060 --> 00:22:29,260
+أو البويضة الملقحة لما تصل إلى ال two stage خصوصا
+
+325
+00:22:29,260 --> 00:22:34,200
+ال embryo mouse أو ال mouse of embryo البيروفيت تم
+
+326
+00:22:34,200 --> 00:22:39,290
+فيما بعد اكتشافه واستخدامهأعطى نتائج فعالة في
+
+327
+00:22:39,290 --> 00:22:45,690
+تطوير وتحسين نضوج الزيجون وتم استخدامه as a
+
+328
+00:22:45,690 --> 00:22:48,970
+primary source of energy for a cleavage stage
+
+329
+00:22:48,970 --> 00:22:52,570
+embryo including a human where it is used
+
+330
+00:22:52,570 --> 00:22:56,210
+throughout development of a blastocyst stageيعني
+
+331
+00:22:56,210 --> 00:22:59,310
+بمعنى أخر البيوروفيت أصبح استخدامه أكثر من
+
+332
+00:22:59,310 --> 00:23:04,250
+اللاكتات as source of energy سواء كان في المرحلة
+
+333
+00:23:04,250 --> 00:23:07,470
+المتقدمة أول تلات أيام أو في مرحلة الـPlesiocyst
+
+334
+00:23:07,470 --> 00:23:12,190
+اللي بتظهر في اليوم الرابع أو الخامس أو السادس بعض
+
+335
+00:23:12,190 --> 00:23:16,590
+الأحماض الأمنية التي تلعب دور أساسي كمصدر من مصادر
+
+336
+00:23:16,590 --> 00:23:20,970
+الطاقة المستخدمة من قبل الجنين أثناء عملية ال
+
+337
+00:23:20,970 --> 00:23:24,540
+developmentولكن أيضًا تساعد في التدخل في
+
+338
+00:23:24,540 --> 00:23:27,780
+الهيموستاسي داخل الخلايا رغم أنها تعتبر مصدر
+
+339
+00:23:27,780 --> 00:23:33,040
+للطاقة أن الـ Amino Acid أصبحت تستخدم كمصدر مهم
+
+340
+00:23:33,040 --> 00:23:36,320
+جدًا للمحافظة على الهيموستاسي داخل الخلايا فهي
+
+341
+00:23:36,320 --> 00:23:40,900
+تعمل كـ Buffering أيضًا تعمل كـ Antioxidant وتعمل
+
+342
+00:23:40,900 --> 00:23:45,280
+أيضًا Organic Osmolites to control cell volume
+
+343
+00:23:45,280 --> 00:23:49,980
+يعني الـ Amino Acid مادة مش هينة في الـ Culture
+
+344
+00:23:49,980 --> 00:23:55,090
+Media خاصةفي بعد اليوم التالت Amino acid,
+
+345
+00:23:55,290 --> 00:23:58,950
+pyruvate, lactate were recognized as preferred
+
+346
+00:23:58,950 --> 00:24:03,850
+energy source for all or for the early embryo over
+
+347
+00:24:03,850 --> 00:24:08,050
+glucose يعني لو أنا قرنت ال substance كلهم مع ال
+
+348
+00:24:08,050 --> 00:24:12,590
+glucose بلاقي إنه أكثر استخدام لمصادر الطاقة لل
+
+349
+00:24:12,590 --> 00:24:17,070
+embryo وخاصة في المناطق المبكرة يعني أول يومين تلت
+
+350
+00:24:17,070 --> 00:24:21,530
+أيام يستخدم ال amino acid كمصدر للطاقةبيروفيت والـ
+
+351
+00:24:21,530 --> 00:24:27,630
+Lactate يعتبر مفضل أو مفضلين عن الجليكوز بالنسبة
+
+352
+00:24:27,630 --> 00:24:32,850
+للجنين في أول أيامه في أول أيام طبعا بعض الدراسات
+
+353
+00:24:32,850 --> 00:24:37,930
+التي حدثت على ال mouse embryo Demonstrated وجدت إن
+
+354
+00:24:37,930 --> 00:24:41,030
+non-essential amino acids are important during
+
+355
+00:24:41,030 --> 00:24:42,610
+early embryo development
+
+356
+00:24:46,110 --> 00:24:48,410
+Essentially and non-essential amino acids should
+
+357
+00:24:48,410 --> 00:24:52,450
+be included in the media after 8th to 6th cell
+
+358
+00:24:52,450 --> 00:24:56,450
+stage ايش يعني 6th stage؟ خدوا بالكوا اليوم الأول
+
+359
+00:24:56,450 --> 00:25:05,190
+انقسم بقدر 2 cell التاني 4 التالت 8 الرابع 16
+
+360
+00:25:05,190 --> 00:25:12,470
+الخامس 32 السادس 64 لأن الأمر متضائف هي المقصود من
+
+361
+00:25:12,470 --> 00:25:17,360
+انقسم إذا ال 8 خلايا بيكون في اليومالثالث لأنه
+
+362
+00:25:17,360 --> 00:25:21,020
+عندى أربعة تمانية هذه الفكرة الموجودة فبقول لي
+
+363
+00:25:21,020 --> 00:25:25,080
+ببساطة جدا أنه بناء على التجربة وجدوا أن الأحماض
+
+364
+00:25:25,080 --> 00:25:29,220
+الأمينية الغير أساسية تعتبر مهمة لتطور الجنين في
+
+365
+00:25:29,220 --> 00:25:32,660
+مراحل الأولى بينما الأساسية والغير أساسية من حيث
+
+366
+00:25:32,660 --> 00:25:37,640
+الأحماض الأمينية تعتبر لتطور ونضوج ونمو الجنين في
+
+367
+00:25:37,640 --> 00:25:42,760
+المراحل بعد اليوم التالت لما يصل لست اتمن خلايا أو
+
+368
+00:25:42,760 --> 00:25:47,720
+ستاشر خلية يعني في اليوم التالتواليوم الرابع The
+
+369
+00:25:47,720 --> 00:25:52,780
+use of amino acid and specifically glutamine in
+
+370
+00:25:52,780 --> 00:25:55,700
+the media is associated with ammonium accumulation
+
+371
+00:25:55,700 --> 00:25:59,660
+هل في accumulation للأمونيا بتصير داخل ال media أو
+
+372
+00:25:59,660 --> 00:26:03,380
+بتصير داخل الأكيد في accumulation لأنه خلية
+
+373
+00:26:03,380 --> 00:26:08,600
+والخلية بيطلع منها waste product واجدوا على سبيل
+
+374
+00:26:08,600 --> 00:26:13,360
+المثال إن embryo واحد في اليوم الرابع يستطيع إنتاج
+
+375
+00:26:13,360 --> 00:26:17,500
+100 micro mole من الأمونيا and the amino acid
+
+376
+00:26:17,500 --> 00:26:21,220
+breakdown added few charge .. few ذرع to this
+
+377
+00:26:21,220 --> 00:26:24,620
+which can affected in the development capacity and
+
+378
+00:26:24,620 --> 00:26:27,740
+gene expression يعني تصور أنا عندي embryo في اليوم
+
+379
+00:26:27,740 --> 00:26:35,040
+الرابع يعني عدد خليات2، 4، 8، 16 خلية يستطيع إنتاج
+
+380
+00:26:35,040 --> 00:26:38,760
+100 micromole من الأمونيا بالإضافة إلى وجود
+
+381
+00:26:38,760 --> 00:26:43,560
+الأحماض الأمنية التي تتكسر داخل الوسط أو داخل ال
+
+382
+00:26:43,560 --> 00:26:47,280
+media هيزيد مستوى الأمونيا زيادة مستوى الأمونيا
+
+383
+00:26:47,280 --> 00:26:51,460
+بيعمل feedback أو negative feedback على ال
+
+384
+00:26:51,460 --> 00:26:55,000
+capacity لل gene development لل embryo development
+
+385
+00:26:55,000 --> 00:26:58,520
+و ال gene expression يعني في تأثير سلبي على ال
+
+386
+00:26:58,520 --> 00:27:02,960
+gene expression لل embryoوالـ capacity التي تتعلق
+
+387
+00:27:02,960 --> 00:27:07,020
+بالـ embryo development فبالتالي لازم نتخلص منها
+
+388
+00:27:07,020 --> 00:27:12,220
+من خلال وجود system معين في الـ osmolarity an
+
+389
+00:27:12,220 --> 00:27:18,340
+important concept to be aware of in regard to
+
+390
+00:27:18,340 --> 00:27:22,560
+culture media is osmolarity and it is resulting
+
+391
+00:27:22,560 --> 00:27:26,820
+affected one cell on the cell volume and embryo
+
+392
+00:27:26,820 --> 00:27:30,680
+development ال osmolarity لو اختلفتال volume الخاص
+
+393
+00:27:30,680 --> 00:27:34,420
+بال embryo هيختلف ال development الخاص بال embryo
+
+394
+00:27:34,420 --> 00:27:38,820
+هتختلف فعلى سبيل المثال بناء على التجارب وجدوا ان
+
+395
+00:27:38,820 --> 00:27:42,500
+ال high osmolarity كان affected embryo development
+
+396
+00:27:42,500 --> 00:27:46,980
+and was one of the underlying causes of the two
+
+397
+00:27:46,980 --> 00:27:50,380
+cell blocking observed in early embryo culture
+
+398
+00:27:50,380 --> 00:27:54,060
+media study شو يعني معنى الكلام؟ وجدوا ان ارتفاع
+
+399
+00:27:54,060 --> 00:27:58,290
+ال osmolarity في ال media خلالتحضين الجنين في هذه
+
+400
+00:27:58,290 --> 00:28:01,830
+الـ media في اليوم التالت أو اليوم الرابع يؤدي إلى
+
+401
+00:28:01,830 --> 00:28:06,410
+إيقاف أو اليوم التاني ممكن يؤدي إلى إيقاف تطول
+
+402
+00:28:06,410 --> 00:28:10,510
+الجنين في الاتنين cell يعني ينقسم في انقسام الأول
+
+403
+00:28:10,510 --> 00:28:14,650
+وانقسام التاني بس يعني بيقف فقط أن خلية فيها
+
+404
+00:28:14,650 --> 00:28:18,190
+خليتين خلية كبيرة بداخل ال two cell يعني تقريبا
+
+405
+00:28:18,190 --> 00:28:22,150
+يقف في نهاية اليوم الأول و بداية اليوم التاني ماهو
+
+406
+00:28:22,150 --> 00:28:26,670
+هذا اللي يجعله يجف انقسام الخلايا؟blocking a two
+
+407
+00:28:26,670 --> 00:28:32,830
+-cell هو وجود نسبة ومستوى عالي من الـosmolarity so
+
+408
+00:28:32,830 --> 00:28:35,970
+high osmolarity will be affected on the
+
+409
+00:28:35,970 --> 00:28:39,410
+development of embryo and it is considered as the
+
+410
+00:28:39,410 --> 00:28:45,030
+one causes of two-cell block بعض الدراسات اللي
+
+411
+00:28:45,030 --> 00:28:49,010
+أجريت على أحماض أمينية مختلفة وجدت إن provided
+
+412
+00:28:49,010 --> 00:28:52,670
+prediction against high osmolarity and are those
+
+413
+00:28:52,670 --> 00:28:57,280
+recommended in all mediaدراسات حدثت على بعض
+
+414
+00:28:57,280 --> 00:28:59,920
+اللحماض الأمنية وجدت إن هذه اللحماض الأمنية بتلعب
+
+415
+00:28:59,920 --> 00:29:03,360
+دور إيجابي في حماية ال embryo من ال isoglarity
+
+416
+00:29:03,360 --> 00:29:07,240
+فبالتالي بتمنع من ال two cell block بعض ال
+
+417
+00:29:07,240 --> 00:29:11,460
+additive زي ال antioxidant يمكن أن تضاف إلى ال
+
+418
+00:29:11,460 --> 00:29:14,220
+media ومن أشهر هذه ال antioxidant ال pyruvate it
+
+419
+00:29:14,220 --> 00:29:18,620
+will be pyruvate act as powerful antioxidant
+
+420
+00:29:18,620 --> 00:29:22,680
+فبالتالي بيحمي ال embryo من التأثير السلبي والسيء
+
+421
+00:29:22,680 --> 00:29:28,160
+لل reactive oxygen speciesمن أشهر أنواع الـ
+
+422
+00:29:28,160 --> 00:29:33,280
+Antioxidant إيثايل بيروفيت وميثايل بيروفيت وأيضا
+
+423
+00:29:33,280 --> 00:29:37,200
+في عيني الـ Sodium Pyruvate بيعتبر من أشهر أنواع
+
+424
+00:29:37,200 --> 00:29:43,540
+الـ Antioxidant التي قد تستخدم في حماية الـ embryo
+
+425
+00:29:43,540 --> 00:29:50,630
+من الـ oxidative stressوتعمل بشكل كبير جدا على
+
+426
+00:29:50,630 --> 00:29:53,790
+تدعيم الـ embryo الخاص بالماوس خلال عملية الـ
+
+427
+00:29:53,790 --> 00:29:59,170
+development عالية مصدر من مصادر الطاقة مصدر من
+
+428
+00:29:59,170 --> 00:30:03,030
+مصادر الطاقة فبالتالي الـ Pyruvate مهم جدا في
+
+429
+00:30:03,030 --> 00:30:07,710
+إحداث stability بنسبة و بكمية و بمستوى عالي جدا
+
+430
+00:30:07,710 --> 00:30:13,850
+كمان بعمل increasing لـ membrane permeability
+
+431
+00:30:13,850 --> 00:30:19,190
+factor which could have an impact on bothImbrio or
+
+432
+00:30:19,190 --> 00:30:24,110
+imbrio metabolism or ability to scavenge الرُس
+
+433
+00:30:24,110 --> 00:30:29,950
+يعني مقاومة الرُس التغلب على الرُس الرُس اختصار لل
+
+434
+00:30:29,950 --> 00:30:35,430
+reactive oxygen species وهي very toxic substance
+
+435
+00:30:35,430 --> 00:30:42,050
+harmful harmful harmful سؤال بطرح نفسه هل الجليكوز
+
+436
+00:30:42,050 --> 00:30:47,930
+يعتبر مادة أساسية او مادة مضرة؟الجليكوز تُعتبر
+
+437
+00:30:47,930 --> 00:30:53,090
+essential أو harmful substance The toxicity of
+
+438
+00:30:53,090 --> 00:30:57,210
+glicose for the early embryo is controversial
+
+439
+00:30:57,210 --> 00:31:01,930
+بمعنى آخر اختلف العلماء حول تأثير الجليكوز على
+
+440
+00:31:01,930 --> 00:31:05,430
+تطور الجنين في مراحل الأولية بعضهم قال بيأثر
+
+441
+00:31:05,430 --> 00:31:08,650
+التأثير السلبي بعضهم قال يعني toxic و بعضهم قال لأ
+
+442
+00:31:08,650 --> 00:31:11,950
+ما إلو أي علاقة أو ما إلو تأثير Provoist study
+
+443
+00:31:11,950 --> 00:31:15,870
+conclude that glicose is not harmful for the early
+
+444
+00:31:15,870 --> 00:31:22,040
+embryoفي المقابل في دراسات تانية قالت إن الجليكوز
+
+445
+00:31:22,040 --> 00:31:27,640
+والفركتوز يعتبروا من المكونات or fractose is
+
+446
+00:31:27,640 --> 00:31:31,080
+essential and amino acid were considered a key of
+
+447
+00:31:31,080 --> 00:31:34,140
+overcoming two cell blocking possible by
+
+448
+00:31:34,140 --> 00:31:38,280
+regulating the reactive oxygen species يعني بمعنى
+
+449
+00:31:38,280 --> 00:31:44,760
+أخر دراسة أخرى قالت وحدثت أن الجليكوز والفركتوز
+
+450
+00:31:44,760 --> 00:31:48,710
+essentialوmylo acid بلعب دور كبير جدا في حماية ال
+
+451
+00:31:48,710 --> 00:31:53,050
+embryo من الروس ويمنع حدوث ال two cell blocking
+
+452
+00:31:53,050 --> 00:31:57,810
+study showed that the reduction in the embryo
+
+453
+00:31:57,810 --> 00:32:00,010
+quality was associated with the high level of
+
+454
+00:32:00,010 --> 00:32:04,930
+glucose أي دراسة تانية in another site or in
+
+455
+00:32:04,930 --> 00:32:08,570
+another hand another study found that a media
+
+456
+00:32:08,570 --> 00:32:12,980
+content 4.7 millimole per literChelicose
+
+457
+00:32:12,980 --> 00:32:15,580
+supporting the human embryo development to
+
+458
+00:32:15,580 --> 00:32:20,180
+plasticest with high effectiveness يعني حتى
+
+459
+00:32:20,180 --> 00:32:25,880
+الدراسات مختلفة علشان كده أنا مابقدر أحكم على مادة
+
+460
+00:32:25,880 --> 00:32:29,840
+إلا بعد أدرسها على المجتمع اللي أنا بعيش فيه لأنه
+
+461
+00:32:29,840 --> 00:32:35,160
+من مجتمع لمجتمع من عدد لعدد تختلف نتائج الدراسة
+
+462
+00:32:35,160 --> 00:32:39,160
+study compared three cultures فيه study عملت
+
+463
+00:32:39,160 --> 00:32:43,350
+comparingلتأثير تلت أنواع من الـ Media الـ Media
+
+464
+00:32:43,350 --> 00:32:47,090
+الأولى P1 بتحتوى على جليكوز Free مافيش فيها جليكوز
+
+465
+00:32:47,090 --> 00:32:52,750
+يعني و Media اسمها SIM1 بتحتوى على 1 ميلي مول من
+
+466
+00:32:52,750 --> 00:32:57,650
+الجليكوز و Media اسمها Universal IVF Media بتحتوى
+
+467
+00:32:57,650 --> 00:33:02,230
+على 5.55 ميلي مول Bare Little للجليكوز يعني Media
+
+468
+00:33:02,230 --> 00:33:05,090
+مافيش فيهاو ميديا فيها كمية قليلة و ميديا فيها
+
+469
+00:33:05,090 --> 00:33:08,790
+كمية كبيرة جدا طب النتائج ببساطة جدا demonstrate
+
+470
+00:33:08,790 --> 00:33:12,490
+that high concentration did not affected in the
+
+471
+00:33:12,490 --> 00:33:17,390
+embryo quality but result in high polyploidy
+
+472
+00:33:17,390 --> 00:33:24,790
+fertilized and affected cleavage rate while SIMI
+
+473
+00:33:24,790 --> 00:33:27,750
+had beneficial effect on the embryo development
+
+474
+00:33:28,360 --> 00:33:32,500
+يعني بمعنى آخر الدراسة استخلصت إن وجود الجليكوز
+
+475
+00:33:32,500 --> 00:33:36,140
+بكميات كبيرة جدا ما بتأثر على جودة الـ Imperium
+
+476
+00:33:36,140 --> 00:33:41,980
+كجودة ولكن ممكن تؤدي إلى وجود polyploidy
+
+477
+00:33:41,980 --> 00:33:46,180
+fertilization ممكن تؤثر على الـ cleavage rate لل
+
+478
+00:33:46,180 --> 00:33:51,160
+Imperium بينما النوع التاني الـ media رقم 2 اللي
+
+479
+00:33:51,160 --> 00:33:57,380
+فيها كمية قليلة وجد إن هيله تأثير إيجابي علىنمو
+
+480
+00:33:57,380 --> 00:34:02,500
+وتطور الجنين it has been suggested that glucose is
+
+481
+00:34:02,500 --> 00:34:07,700
+not inhibitor or have negative effect for the
+
+482
+00:34:07,700 --> 00:34:11,380
+early embryo and the concentration that mimics the
+
+483
+00:34:11,380 --> 00:34:15,180
+in vivo condition of voiding extremely خلاصة هذه
+
+484
+00:34:15,180 --> 00:34:19,960
+الدراسة قالت أن الجليكوز لا يؤثر تأثير سلبي على
+
+485
+00:34:19,960 --> 00:34:26,150
+تطور الجنين ونموه طالمايحاكي نسبته نسبة طبيعية
+
+486
+00:34:26,150 --> 00:34:30,090
+الموجودة في جسم السيدة أو في جسم الأنثى ما لم يزيد
+
+487
+00:34:30,090 --> 00:34:34,510
+ما لم يزيد زيادته ساعتها بيأثر مش على ال quality
+
+488
+00:34:34,510 --> 00:34:40,830
+بيأثر على ال polyploidy بيأثر على ال polyploidy
+
+489
+00:34:40,830 --> 00:34:43,870
+بيأثر على ال polyploidy fertilization وبيأثر على
+
+490
+00:34:43,870 --> 00:34:47,730
+ال cleavage rate بيأثر على ال cleavage rate بهذا
+
+491
+00:34:47,730 --> 00:34:52,550
+الشكل نكون قد أنهينا من ال chapterهذا الشبتر
+
+492
+00:34:52,550 --> 00:34:56,110
+الشبتر الرابع على أمل أن نلتقي في شبتر جديد الشبتر
+
+493
+00:34:56,110 --> 00:34:59,970
+الجديد سوف نتحدث فيه عن كيف تتم عملية الحقن
+
+494
+00:34:59,970 --> 00:35:06,710
+process على أمل أن نلتقي دائما على خير دمتم في حفظ
+
+495
+00:35:06,710 --> 00:35:06,910
+الله
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/wi8cqG8vR_Q_raw.json b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/wi8cqG8vR_Q_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..f403a91d93e8511902f88e5027d99f2aff6bdf59
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/wi8cqG8vR_Q_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2489, "start": 0.79, "end": 24.89, "text": "باسم الله الرحمن الرحيم والصلاة والسلام على أشرف المرسلين سيدنا محمد وعلى آله وصحبه أجمعين اليوم سوف نستكمل الجزء الأخير من هذا ال chapter والذي سوف يتكلم بشكل أساسي عن ال culture media بمعنى ما هي الأوساط التي يمكن أن تستخدم خلال عملية التلقيح الصناعي", "tokens": [3555, 32277, 2304, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 16070, 9381, 15040, 3660, 16070, 3794, 37440, 15844, 5551, 8592, 28480, 9673, 2288, 3794, 1211, 9957, 8608, 25708, 8315, 3714, 35571, 3215, 4032, 3615, 23942, 19753, 43761, 4032, 9381, 5016, 3555, 3224, 5551, 7435, 2304, 3615, 9957, 45595, 20498, 8608, 38688, 8717, 14851, 24793, 1211, 25724, 11622, 38207, 16247, 9778, 13546, 9154, 23758, 2423, 7187, 16070, 8848, 1829, 8608, 38688, 7251, 2655, 4117, 19528, 4724, 8592, 28820, 5551, 3794, 32277, 1829, 18871, 2423, 3713, 3021, 4724, 2304, 3615, 1863, 7578, 19446, 39896, 16247, 41779, 41193, 38392, 7251, 43020, 14739, 6055, 14851, 9778, 40448, 16490, 1211, 6027, 6225, 42213, 10632, 16712, 1211, 38436, 5016, 31767, 8315, 3615, 1829], "avg_logprob": -0.07355667442335921, "compression_ratio": 1.743083003952569, "no_speech_prob": 5.662441253662109e-06, "words": [{"start": 0.79, "end": 1.17, "word": "باسم", "probability": 0.7890625}, {"start": 1.17, "end": 1.51, "word": " الله", "probability": 0.96875}, {"start": 1.51, "end": 2.11, "word": " الرحمن", "probability": 0.9619140625}, {"start": 2.11, "end": 2.67, "word": " الرحيم", "probability": 0.9918619791666666}, {"start": 2.67, "end": 3.29, "word": " والصلاة", "probability": 0.88232421875}, {"start": 3.29, "end": 3.85, "word": " والسلام", "probability": 0.9235026041666666}, {"start": 3.85, "end": 4.15, "word": " على", "probability": 0.744140625}, {"start": 4.15, "end": 4.65, "word": " أشرف", "probability": 0.9765625}, {"start": 4.65, "end": 5.41, "word": " المرسلين", "probability": 0.9916015625}, {"start": 5.41, "end": 5.99, "word": " سيدنا", "probability": 0.9749348958333334}, {"start": 5.99, "end": 6.59, "word": " محمد", "probability": 0.9903971354166666}, {"start": 6.59, "end": 7.01, "word": " وعلى", "probability": 0.9396158854166666}, {"start": 7.01, "end": 7.53, "word": " آله", "probability": 0.9453125}, {"start": 7.53, "end": 8.35, "word": " وصحبه", "probability": 0.97548828125}, {"start": 8.35, "end": 9.65, "word": " أجمعين", "probability": 0.971875}, {"start": 9.65, "end": 10.21, "word": " اليوم", "probability": 0.9150390625}, {"start": 10.21, "end": 10.61, "word": " سوف", "probability": 0.98046875}, {"start": 10.61, "end": 11.39, "word": " نستكمل", "probability": 0.9835205078125}, {"start": 11.39, "end": 11.89, "word": " الجزء", "probability": 0.9635416666666666}, {"start": 11.89, "end": 12.49, "word": " الأخير", "probability": 0.8590494791666666}, {"start": 12.49, "end": 12.77, "word": " من", "probability": 0.9833984375}, {"start": 12.77, "end": 13.09, "word": " هذا", "probability": 0.97607421875}, {"start": 13.09, "end": 13.17, 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{"start": 19.85, "end": 20.17, "word": " هي", "probability": 0.92138671875}, {"start": 20.17, "end": 21.25, "word": " الأوساط", "probability": 0.9283854166666666}, {"start": 21.25, "end": 21.53, "word": " التي", "probability": 0.90576171875}, {"start": 21.53, "end": 21.95, "word": " يمكن", "probability": 0.978271484375}, {"start": 21.95, "end": 22.15, "word": " أن", "probability": 0.66796875}, {"start": 22.15, "end": 22.77, "word": " تستخدم", "probability": 0.95703125}, {"start": 22.77, "end": 23.19, "word": " خلال", "probability": 0.9892578125}, {"start": 23.19, "end": 23.71, "word": " عملية", "probability": 0.9920247395833334}, {"start": 23.71, "end": 24.35, "word": " التلقيح", "probability": 0.8897705078125}, {"start": 24.35, "end": 24.89, "word": " الصناعي", "probability": 0.9931640625}], "temperature": 1.0}, {"id": 2, "seek": 5240, "start": 25.34, "end": 52.4, "text": "ما هي الأوساط التي يمكن أن تستخدم خلال نضوج وانضاج البويضات خارج الرحم وما هي مكونات هذه الأوساط وما هي الهدف الأساسي من استخدام هذه المكونات ال culture media بشكل عام هي عبارة عن وسط غذائي يشبه وسط الغذاء التي تكون متواجدة فيه البويضة وتستخدم يا إما من أجل إنماء البويضة", "tokens": [15042, 39896, 16247, 41779, 41193, 38392, 7251, 43020, 14739, 6055, 14851, 9778, 40448, 16490, 1211, 6027, 8717, 11242, 29245, 4032, 7649, 11242, 26108, 29739, 45865, 11242, 9307, 16490, 9640, 7435, 34892, 35571, 4032, 15042, 39896, 3714, 4117, 2407, 8315, 2655, 29538, 16247, 41779, 41193, 4032, 15042, 39896, 2423, 3224, 3215, 5172, 16247, 3794, 32277, 1829, 9154, 44713, 9778, 3215, 10943, 29538, 9673, 4117, 2407, 8315, 2655, 2423, 3713, 3021, 4724, 8592, 28820, 6225, 10943, 39896, 6225, 3555, 9640, 3660, 18871, 46952, 9566, 32771, 8848, 16373, 1829, 7251, 8592, 3555, 3224, 46952, 9566, 6024, 118, 8848, 16606, 38392, 6055, 30544, 44650, 2407, 26108, 41891, 8978, 3224, 29739, 45865, 11242, 3660, 34683, 14851, 9778, 40448, 35186, 11933, 15042, 9154, 5551, 7435, 1211, 36145, 2304, 16606, 29739, 45865, 11242, 3660], 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{"start": 390.9, "end": 391.08, "word": " على", "probability": 0.9267578125}, {"start": 391.08, "end": 391.4, "word": " أكتر", "probability": 0.9432373046875}, {"start": 391.4, "end": 391.66, "word": " من", "probability": 0.9951171875}, {"start": 391.66, "end": 392.32, "word": " 32", "probability": 0.88525390625}, {"start": 392.32, "end": 392.96, "word": " خلية", "probability": 0.9700520833333334}], "temperature": 1.0}, {"id": 16, "seek": 42317, "start": 393.57, "end": 423.17, "text": "هذا تعريف البسيط خلّينا نعرفها بهذا الشكل حتى الآن و قدام هناخد استفادة شوية عن موريلا to the early plastocyst stage and the aortas is like not well occupied to support the cleavage stage embryo يعني بيقول لي ببساطة جدا أنه في الوضع الطبيعي و التلقيح الطبيعي ال embryo لن ينتقل إلى الرحم إلا بعد أن تتحول لموريلا", "tokens": [3224, 15730, 37279, 16572, 5172, 29739, 3794, 1829, 9566, 16490, 1211, 11703, 9957, 995, 8717, 3615, 28480, 11296, 39627, 15730, 25124, 28820, 11331, 49975, 6024, 48506, 4032, 12174, 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{"start": 398.69, "end": 399.13, "word": " موريلا", "probability": 0.700408935546875}, {"start": 399.13, "end": 400.57, "word": " to", "probability": 0.50390625}, {"start": 400.57, "end": 400.81, "word": " the", "probability": 0.91748046875}, {"start": 400.81, "end": 401.19, "word": " early", "probability": 0.9140625}, {"start": 401.19, "end": 401.97, "word": " plastocyst", "probability": 0.6986490885416666}, {"start": 401.97, "end": 402.49, "word": " stage", "probability": 0.8681640625}, {"start": 402.49, "end": 403.33, "word": " and", "probability": 0.892578125}, {"start": 403.33, "end": 403.91, "word": " the", "probability": 0.81787109375}, {"start": 403.91, "end": 404.51, "word": " aortas", "probability": 0.7552083333333334}, {"start": 404.51, "end": 404.75, "word": " is", "probability": 0.8935546875}, {"start": 404.75, "end": 405.07, "word": " like", "probability": 0.453125}, {"start": 405.07, "end": 405.33, "word": " not", "probability": 0.857421875}, {"start": 405.33, "end": 405.71, "word": " well", "probability": 0.8505859375}, {"start": 405.71, "end": 406.63, "word": " occupied", "probability": 0.0992431640625}, {"start": 406.63, "end": 406.83, "word": " to", "probability": 0.97509765625}, {"start": 406.83, "end": 408.21, "word": " support", "probability": 0.96044921875}, {"start": 408.21, "end": 408.45, "word": " the", "probability": 0.701171875}, {"start": 408.45, "end": 408.87, "word": " cleavage", "probability": 0.9685872395833334}, {"start": 408.87, "end": 409.25, "word": " stage", "probability": 0.8779296875}, {"start": 409.25, "end": 409.77, "word": " embryo", "probability": 0.931884765625}, {"start": 409.77, "end": 410.37, "word": " يعني", "probability": 0.92333984375}, {"start": 410.37, "end": 410.69, "word": " بيقول", "probability": 0.9547526041666666}, {"start": 410.69, "end": 410.83, "word": " لي", "probability": 0.25537109375}, {"start": 410.83, "end": 411.53, "word": " ببساطة", "probability": 0.99111328125}, {"start": 411.53, "end": 411.95, "word": " جدا", "probability": 0.9814453125}, {"start": 411.95, "end": 413.35, "word": " أنه", "probability": 0.70654296875}, {"start": 413.35, "end": 413.87, "word": " في", "probability": 0.95849609375}, {"start": 413.87, "end": 414.21, "word": " الوضع", "probability": 0.99267578125}, {"start": 414.21, "end": 414.77, "word": " الطبيعي", "probability": 0.9847412109375}, {"start": 414.77, "end": 414.91, "word": " و", "probability": 0.51171875}, {"start": 414.91, "end": 415.37, "word": " التلقيح", "probability": 0.81103515625}, {"start": 415.37, "end": 415.97, "word": " الطبيعي", "probability": 0.9898681640625}, {"start": 415.97, "end": 416.31, "word": " ال", "probability": 0.880859375}, {"start": 416.31, "end": 416.93, "word": " embryo", "probability": 0.872314453125}, {"start": 416.93, "end": 417.25, "word": " لن", "probability": 0.99072265625}, {"start": 417.25, "end": 417.89, "word": " ينتقل", "probability": 0.984130859375}, {"start": 417.89, "end": 418.21, "word": " إلى", 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" إلى", "probability": 0.884765625}, {"start": 426.38, "end": 427.16, "word": " Plastocyst", "probability": 0.647613525390625}, {"start": 427.16, "end": 428.16, "word": " والـ", "probability": 0.4742431640625}, {"start": 428.16, "end": 428.8, "word": " Plastocyst", "probability": 0.8914794921875}, {"start": 428.8, "end": 429.34, "word": " أكتر", "probability": 0.9794921875}, {"start": 429.34, "end": 429.68, "word": " من", "probability": 0.9833984375}, {"start": 429.68, "end": 430.98, "word": " 64", "probability": 0.93310546875}, {"start": 430.98, "end": 431.6, "word": " خلية", "probability": 0.9786783854166666}, {"start": 431.6, "end": 433.04, "word": " ببساطة", "probability": 0.9447265625}, {"start": 433.04, "end": 433.62, "word": " يعني", "probability": 0.8623046875}, {"start": 433.62, "end": 433.8, "word": " إذا", "probability": 0.918701171875}, {"start": 433.8, "end": 433.98, "word": " كان", "probability": 0.99658203125}, {"start": 433.98, "end": 434.38, "word": " موريلا", 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number of oocyte result is very high circulating concentration of estrogen that led to abnormal development and functional activity of uterus خلال عملية تحفيز المبيض الزوجة والسيدة بتاخد كمية كبيرة جدا من الهرمونات", "tokens": [2407, 47283, 3215, 14407, 20666, 4117, 23032, 6027, 15042, 3714, 13063, 1829, 15040, 11933, 15040, 11933, 33753, 1829, 26108, 9307, 11296, 23032, 6027, 15042, 2149, 525, 31078, 372, 11933, 15040, 11933, 33753, 1829, 26108, 9307, 3714, 46456, 46538, 3660, 2423, 39184, 26307, 345, 310, 1513, 259, 37405, 295, 264, 14187, 822, 281, 2893, 364, 6505, 1230, 295, 277, 31078, 975, 1874, 307, 588, 1090, 39749, 9856, 295, 44754, 300, 4684, 281, 32847, 3250, 293, 11745, 5191, 295, 2839, 37287, 16490, 1211, 6027, 6225, 42213, 10632, 6055, 5016, 41185, 11622, 9673, 21292, 11242, 6024, 110, 29245, 3660, 16070, 3794, 25708, 3660, 39894, 47283, 3215, 9122, 2304, 10632, 9122, 3555, 48923, 10874, 28259, 9154, 2423, 3224, 2288, 2304, 2407, 8315, 2655], "avg_logprob": 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"seek": 81418, "start": 785.02, "end": 814.18, "text": "preparation media و ال PVP في ال oil طبعا انا بستخدم ال oil بشكل كبير جدا عشان اغطي ال media لما انا بتردش اضيف قطرة drop .. drop .. drop .. drop من ال media لازم اغطيها ب oil هذا ال oil بيحمي ال media و بيحمي البويضة اللي موجودة داخل ال media او بيحمي ال embryo اللي موجود داخل ال media من ال external environment factor فبيعطيها كمية حرارة ثابتة cosmolarity ثابتة", "tokens": [3712, 2181, 399, 3021, 4032, 2423, 23035, 47, 8978, 2423, 3184, 23032, 3555, 3615, 995, 1975, 8315, 4724, 14851, 9778, 40448, 2423, 3184, 4724, 8592, 28820, 9122, 3555, 13546, 10874, 28259, 6225, 8592, 7649, 1975, 17082, 9566, 1829, 2423, 3021, 5296, 15042, 1975, 8315, 39894, 2288, 3215, 8592, 1975, 11242, 33911, 12174, 9566, 25720, 3270, 4386, 3270, 4386, 3270, 4386, 3270, 9154, 2423, 3021, 5296, 31377, 2304, 1975, 17082, 9566, 1829, 11296, 4724, 3184, 23758, 2423, 3184, 4724, 1829, 35571, 1829, 2423, 3021, 4032, 4724, 1829, 35571, 1829, 29739, 45865, 11242, 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IVF Media بتحتوى على 5.55 ميلي مول Bare Little للجليكوز يعني Media مافيش فيها", "tokens": [1211, 2655, 10721, 12984, 13546, 6055, 1211, 2655, 14739, 14407, 3615, 9154, 2423, 39184, 14741, 2423, 39184, 14741, 16247, 12610, 7578, 430, 16, 39894, 33753, 2407, 7578, 15844, 10874, 20292, 4117, 2407, 11622, 11551, 19446, 41185, 8592, 8978, 11296, 10874, 20292, 4117, 2407, 11622, 37495, 22653, 4032, 14741, 24525, 2304, 11296, 24738, 16, 39894, 33753, 2407, 7578, 15844, 502, 3714, 1829, 20292, 3714, 12610, 9154, 25724, 20292, 4117, 2407, 11622, 4032, 14741, 24525, 2304, 11296, 22617, 15967, 37, 14741, 39894, 33753, 2407, 7578, 15844, 1025, 13, 13622, 3714, 1829, 20292, 3714, 12610, 43957, 8022, 24976, 7435, 20292, 4117, 2407, 11622, 37495, 22653, 14741, 19446, 41185, 8592, 8978, 11296], "avg_logprob": -0.17732225044058003, "compression_ratio": 1.9744897959183674, "no_speech_prob": 2.6226043701171875e-06, "words": [{"start": 1960.59, "end": 1961.15, "word": "لتأثير", "probability": 0.959375}, 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2007.75, "text": "و ميديا فيها كمية قليلة و ميديا فيها كمية كبيرة جدا طب النتائج ببساطة جدا demonstrate that high concentration did not affected in the embryo quality but result in high polyploidy fertilized and affected cleavage rate while SIMI had beneficial effect on the embryo development", "tokens": [2407, 3714, 1829, 16254, 995, 8978, 11296, 9122, 2304, 10632, 12174, 20292, 37977, 4032, 3714, 1829, 16254, 995, 8978, 11296, 9122, 2304, 10632, 9122, 3555, 48923, 10874, 28259, 23032, 3555, 28239, 2655, 16373, 7435, 4724, 3555, 3794, 41193, 3660, 10874, 28259, 11698, 300, 1090, 9856, 630, 406, 8028, 294, 264, 31588, 78, 3125, 457, 1874, 294, 1090, 6754, 564, 17079, 88, 18512, 1602, 293, 8028, 1233, 706, 609, 3314, 1339, 24738, 40, 632, 14072, 1802, 322, 264, 31588, 78, 3250], "avg_logprob": -0.18923610816767186, "compression_ratio": 1.5045045045045045, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1983.33, "end": 1983.53, "word": "و", "probability": 0.82421875}, 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new file mode 100644
index 0000000000000000000000000000000000000000..9b3949053b85fc93fc042dec6cc50e2440155d9f
--- /dev/null
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@@ -0,0 +1 @@
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{"start": 525.92, "end": 526.22, "word": " body", "probability": 0.89013671875}, {"start": 526.22, "end": 526.82, "word": " مكانه", "probability": 0.97705078125}, {"start": 526.82, "end": 527.5, "word": " بيجب", "probability": 0.8350830078125}, {"start": 527.5, "end": 527.92, "word": " أطلع", "probability": 0.817138671875}, {"start": 527.92, "end": 528.12, "word": " على", "probability": 0.88037109375}, {"start": 528.12, "end": 528.22, "word": " ال", "probability": 0.78173828125}, {"start": 528.22, "end": 528.46, "word": " slide", "probability": 0.974609375}, {"start": 528.46, "end": 528.62, "word": " من", "probability": 0.990234375}, {"start": 528.62, "end": 529.08, "word": " الأسفل", "probability": 0.99365234375}, {"start": 529.08, "end": 529.24, "word": " هي", "probability": 0.466796875}, {"start": 529.24, "end": 529.54, "word": " مكان", "probability": 0.983642578125}, {"start": 529.54, "end": 529.66, "word": " ال", "probability": 0.9580078125}, {"start": 529.66, "end": 529.86, "word": " polar", "probability": 0.9404296875}, {"start": 529.86, "end": 530.14, "word": " body", "probability": 0.90478515625}, {"start": 530.14, "end": 530.6, "word": " بعمله", "probability": 0.8870442708333334}, {"start": 530.6, "end": 531.22, "word": " markering", "probability": 0.61083984375}, {"start": 531.22, "end": 532.38, "word": " بوضع", "probability": 0.8759765625}, {"start": 532.38, "end": 533.1, "word": " دائرة", "probability": 0.9905598958333334}, {"start": 533.1, "end": 533.8, "word": " باستخدام", "probability": 0.9847819010416666}, {"start": 533.8, "end": 534.2, "word": " marker", "probability": 0.814453125}, {"start": 534.2, "end": 534.54, "word": " معين", "probability": 0.993408203125}, {"start": 534.54, "end": 534.94, "word": " بشرط", "probability": 0.8782552083333334}, {"start": 534.94, "end": 535.08, "word": " أن", "probability": 0.453125}, {"start": 535.08, "end": 535.2, "word": " ال", "probability": 0.394287109375}, {"start": 535.2, "end": 535.48, "word": " marker", "probability": 0.96044921875}, {"start": 535.48, "end": 535.9, "word": " حتى", "probability": 0.759521484375}, {"start": 535.9, "end": 536.04, "word": " ال", "probability": 0.76123046875}, {"start": 536.04, "end": 536.32, "word": " marker", "probability": 0.96337890625}, {"start": 536.32, "end": 536.52, "word": " اللي", "probability": 0.747314453125}, {"start": 536.52, "end": 537.12, "word": " يستخدم", "probability": 0.9473876953125}], "temperature": 1.0}, {"id": 22, "seek": 54490, "start": 537.38, "end": 544.9, "text": "في الـ Polar Body أو في الـ Imperium لازم يكونش volatile علشان مايأذيش ال Imperium", "tokens": [41185, 2423, 39184, 3635, 289, 21329, 34051, 8978, 2423, 39184, 18360, 2197, 5296, 31377, 2304, 7251, 30544, 8592, 34377, 11203, 8592, 7649, 19446, 1829, 10721, 8848, 1829, 8592, 2423, 18360, 2197], "avg_logprob": -0.31225585751235485, "compression_ratio": 1.125, "no_speech_prob": 0.0, "words": [{"start": 537.38, "end": 537.58, "word": "في", "probability": 0.7255859375}, {"start": 537.58, "end": 537.72, "word": " الـ", "probability": 0.490234375}, {"start": 537.72, "end": 537.96, "word": " Polar", "probability": 0.580078125}, {"start": 537.96, "end": 538.28, "word": " Body", "probability": 0.56103515625}, {"start": 538.28, "end": 539.16, "word": " أو", "probability": 0.7724609375}, {"start": 539.16, "end": 539.36, "word": " في", "probability": 0.6064453125}, {"start": 539.36, "end": 539.5, "word": " الـ", "probability": 0.79833984375}, {"start": 539.5, "end": 540.34, "word": " Imperium", "probability": 0.6162109375}, {"start": 540.34, "end": 541.34, "word": " لازم", "probability": 0.8951822916666666}, {"start": 541.34, "end": 541.78, "word": " يكونش", "probability": 0.9248046875}, {"start": 541.78, "end": 542.2, "word": " volatile", "probability": 0.7861328125}, {"start": 542.2, "end": 542.84, "word": " علشان", "probability": 0.9552408854166666}, {"start": 542.84, "end": 543.68, "word": " مايأذيش", "probability": 0.8166097005208334}, {"start": 543.68, "end": 544.3, "word": " ال", "probability": 0.98681640625}, {"start": 544.3, "end": 544.9, "word": " Imperium", "probability": 0.74609375}], "temperature": 1.0}, {"id": 23, "seek": 57271, "start": 545.89, "end": 572.71, "text": "خلصنا من طريقة الـ Fixation الأولى، بإمكاننا عمل Fixation تانية من خلال استخدام Methanol Acidic Acid Solution من خلال تركيزه 3 Methanol إلى 1 Microliter Acidic Acid يعني ممكن يحضروا 3 Methanol إلى 1 Methanol Acidic Acid أو 100 أو 300 إلى 100 يعني المفروض يكون النسبة 3 إلى 1 3 Methanol إلى 1 Acidic Acid", "tokens": [9778, 1211, 9381, 8315, 9154, 23032, 16572, 28671, 2423, 39184, 25538, 399, 16247, 12610, 7578, 12399, 4724, 28814, 2304, 41361, 8315, 6225, 42213, 25538, 399, 6055, 7649, 10632, 9154, 16490, 1211, 6027, 44713, 9778, 3215, 10943, 48602, 282, 401, 5097, 327, 299, 5097, 327, 318, 3386, 9154, 16490, 1211, 6027, 6055, 31747, 1829, 11622, 3224, 805, 48602, 282, 401, 30731, 502, 5818, 6623, 1681, 5097, 327, 299, 5097, 327, 37495, 22653, 3714, 43020, 7251, 5016, 11242, 2288, 14407, 805, 48602, 282, 401, 30731, 502, 48602, 282, 401, 5097, 327, 299, 5097, 327, 34051, 2319, 34051, 6641, 30731, 2319, 37495, 22653, 9673, 5172, 32887, 11242, 7251, 30544, 28239, 35457, 3660, 805, 30731, 502, 805, 48602, 282, 401, 30731, 502, 5097, 327, 299, 5097, 327], "avg_logprob": -0.20287298254909053, "compression_ratio": 1.8421052631578947, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 545.89, "end": 546.37, "word": "خلصنا", "probability": 0.91650390625}, {"start": 546.37, "end": 546.47, "word": " من", "probability": 0.97412109375}, {"start": 546.47, "end": 546.83, "word": " طريقة", "probability": 0.9840494791666666}, {"start": 546.83, "end": 547.01, "word": " الـ", "probability": 0.8056640625}, {"start": 547.01, "end": 547.39, "word": " Fixation", "probability": 0.6744384765625}, {"start": 547.39, "end": 548.13, "word": " الأولى،", "probability": 0.804443359375}, {"start": 548.13, "end": 548.41, "word": " بإمكاننا", "probability": 0.723681640625}, {"start": 548.41, "end": 548.63, "word": " عمل", "probability": 0.5758056640625}, {"start": 548.63, "end": 549.19, "word": " Fixation", "probability": 0.6822509765625}, {"start": 549.19, "end": 549.67, "word": " تانية", "probability": 0.88427734375}, {"start": 549.67, "end": 550.11, "word": " من", "probability": 0.91552734375}, {"start": 550.11, "end": 550.53, "word": " خلال", "probability": 0.9905598958333334}, {"start": 550.53, "end": 551.31, "word": " استخدام", "probability": 0.9405517578125}, {"start": 551.31, "end": 552.23, "word": " Methanol", "probability": 0.8709309895833334}, {"start": 552.23, "end": 552.77, "word": " Acidic", "probability": 0.9111328125}, {"start": 552.77, "end": 553.07, "word": " Acid", "probability": 0.91259765625}, {"start": 553.07, "end": 553.71, "word": " Solution", "probability": 0.759521484375}, {"start": 553.71, "end": 554.51, "word": " من", "probability": 0.60693359375}, {"start": 554.51, "end": 555.39, "word": " خلال", "probability": 0.9918619791666666}, {"start": 555.39, "end": 556.07, "word": " تركيزه", "probability": 0.95390625}, {"start": 556.07, "end": 556.35, "word": " 3", "probability": 0.479736328125}, {"start": 556.35, "end": 556.97, "word": " Methanol", "probability": 0.7959798177083334}, {"start": 556.97, "end": 557.15, "word": " إلى", "probability": 0.92138671875}, {"start": 557.15, "end": 557.61, "word": " 1", "probability": 0.97998046875}, {"start": 557.61, "end": 559.27, "word": " Microliter", "probability": 0.6967366536458334}, {"start": 559.27, "end": 560.27, "word": " Acidic", "probability": 0.9568684895833334}, {"start": 560.27, "end": 560.43, "word": " Acid", "probability": 0.981201171875}, {"start": 560.43, "end": 560.61, "word": " يعني", "probability": 0.766357421875}, {"start": 560.61, "end": 560.79, "word": " ممكن", "probability": 0.7271728515625}, {"start": 560.79, "end": 561.33, "word": " يحضروا", "probability": 0.788525390625}, {"start": 561.33, "end": 561.83, "word": " 3", "probability": 0.88427734375}, {"start": 561.83, "end": 563.31, "word": " Methanol", "probability": 0.7683919270833334}, {"start": 563.31, "end": 563.45, "word": " إلى", "probability": 0.98681640625}, {"start": 563.45, "end": 563.69, "word": " 1", "probability": 0.9921875}, {"start": 563.69, "end": 563.93, "word": " Methanol", "probability": 0.7390950520833334}, {"start": 563.93, "end": 564.27, "word": " Acidic", "probability": 0.95556640625}, {"start": 564.27, "end": 564.57, "word": " Acid", "probability": 0.98193359375}, {"start": 564.57, "end": 565.05, "word": " أو", "probability": 0.80859375}, {"start": 565.05, "end": 565.39, "word": " 100", "probability": 0.783203125}, {"start": 565.39, "end": 565.95, "word": " أو", "probability": 0.69482421875}, {"start": 565.95, "end": 566.33, "word": " 300", "probability": 0.97021484375}, {"start": 566.33, "end": 566.63, "word": " إلى", "probability": 0.98681640625}, {"start": 566.63, "end": 566.91, "word": " 100", "probability": 0.87744140625}, {"start": 566.91, "end": 567.31, "word": " يعني", "probability": 0.722900390625}, {"start": 567.31, "end": 568.21, "word": " المفروض", "probability": 0.9161376953125}, {"start": 568.21, "end": 568.49, "word": " يكون", "probability": 0.875732421875}, {"start": 568.49, "end": 569.51, "word": " النسبة", "probability": 0.7728678385416666}, {"start": 569.51, "end": 569.97, "word": " 3", "probability": 0.83935546875}, {"start": 569.97, "end": 570.13, "word": " إلى", "probability": 0.82470703125}, {"start": 570.13, "end": 570.37, "word": " 1", "probability": 0.98974609375}, {"start": 570.37, "end": 570.67, "word": " 3", "probability": 0.333984375}, {"start": 570.67, "end": 571.29, "word": " Methanol", "probability": 0.9646809895833334}, {"start": 571.29, "end": 571.47, "word": " إلى", "probability": 0.9833984375}, {"start": 571.47, "end": 571.85, "word": " 1", "probability": 0.9921875}, {"start": 571.85, "end": 572.41, "word": " Acidic", "probability": 0.91259765625}, {"start": 572.41, "end": 572.71, "word": " Acid", "probability": 0.981689453125}], "temperature": 1.0}, {"id": 24, "seek": 58571, "start": 572.87, "end": 585.71, "text": "بقوم بوضع تقريباً 20 أو 30 microliter يعني تلاتة ضرب على الـ polar body هذا بعمل عملية fixation لمدة طبعا فترة زمانية معينة", "tokens": [3555, 4587, 20498, 4724, 2407, 11242, 3615, 6055, 4587, 16572, 3555, 995, 14111, 945, 34051, 2217, 4532, 40632, 37495, 22653, 6055, 1211, 9307, 3660, 48812, 25513, 15844, 2423, 39184, 12367, 1772, 23758, 4724, 25957, 1211, 6225, 42213, 10632, 3191, 399, 32767, 41891, 23032, 3555, 3615, 995, 6156, 2655, 25720, 30767, 2304, 7649, 10632, 20449, 9957, 3660], "avg_logprob": -0.2552083333333333, "compression_ratio": 1.2371794871794872, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 572.87, "end": 573.27, "word": "بقوم", "probability": 0.5791015625}, {"start": 573.27, "end": 574.13, "word": " بوضع", "probability": 0.98828125}, {"start": 574.13, "end": 575.19, "word": " تقريباً", "probability": 0.8317057291666666}, {"start": 575.19, "end": 575.73, "word": " 20", "probability": 0.57568359375}, {"start": 575.73, "end": 576.29, "word": " أو", "probability": 0.2418212890625}, {"start": 576.29, "end": 576.69, "word": " 30", "probability": 0.98095703125}, {"start": 576.69, "end": 577.77, "word": " microliter", "probability": 0.5006103515625}, {"start": 577.77, "end": 578.41, "word": " يعني", "probability": 0.757568359375}, {"start": 578.41, "end": 578.83, "word": " تلاتة", "probability": 0.87109375}, {"start": 578.83, "end": 579.13, "word": " ضرب", "probability": 0.596435546875}, {"start": 579.13, "end": 579.77, "word": " على", "probability": 0.87744140625}, {"start": 579.77, "end": 580.11, "word": " الـ", "probability": 0.5814208984375}, {"start": 580.11, "end": 580.31, "word": " polar", "probability": 0.2174072265625}, {"start": 580.31, "end": 580.65, "word": " body", "probability": 0.888671875}, {"start": 580.65, "end": 581.29, "word": " هذا", "probability": 0.77294921875}, {"start": 581.29, "end": 581.75, "word": " بعمل", "probability": 0.8097330729166666}, {"start": 581.75, "end": 582.21, "word": " عملية", "probability": 0.9827473958333334}, {"start": 582.21, "end": 582.91, "word": " fixation", "probability": 0.75830078125}, {"start": 582.91, "end": 583.53, "word": " لمدة", "probability": 0.94970703125}, {"start": 583.53, "end": 583.97, "word": " طبعا", "probability": 0.9735107421875}, {"start": 583.97, "end": 584.81, "word": " فترة", "probability": 0.8946940104166666}, {"start": 584.81, "end": 585.19, "word": " زمانية", "probability": 0.8670654296875}, {"start": 585.19, "end": 585.71, "word": " معينة", "probability": 0.9947916666666666}], "temperature": 1.0}, {"id": 25, "seek": 61285, "start": 586.03, "end": 612.85, "text": "تقريباً تلاتين ثانية اربعين ثانية هذا كنوع من أنواع ال fixation رقم اتنين بعد ما يصيله fixation another fixation after air dried using methanol at room temperature for five minutes يعني عملت تلت أنواع من ال fixation fixation الأول باستخدام ال water والdrying fixation التاني باستخدام تلاتة إلى واحد methanol acidic acid وال fixation التالت وهو ال methanol على room temperature خمسة minutes خلصت كده", "tokens": [2655, 4587, 16572, 3555, 995, 14111, 6055, 1211, 9307, 9957, 38637, 7649, 10632, 1975, 25513, 3615, 9957, 38637, 7649, 10632, 23758, 9122, 1863, 45367, 9154, 14739, 14407, 3615, 2423, 3191, 399, 12602, 4587, 2304, 1975, 2655, 1863, 9957, 39182, 19446, 7251, 9381, 1829, 43761, 3191, 399, 1071, 3191, 399, 934, 1988, 13538, 1228, 1131, 35735, 412, 1808, 4292, 337, 1732, 2077, 37495, 22653, 6225, 42213, 2655, 6055, 1211, 2655, 14739, 14407, 3615, 9154, 2423, 3191, 399, 3191, 399, 16247, 12610, 4724, 995, 14851, 9778, 3215, 10943, 2423, 1281, 16070, 67, 19076, 3191, 399, 16712, 7649, 1829, 4724, 995, 14851, 9778, 3215, 10943, 6055, 1211, 9307, 3660, 30731, 36764, 24401, 1131, 35735, 39514, 8258, 4032, 6027, 3191, 399, 16712, 6027, 2655, 37037, 2407, 2423, 1131, 35735, 15844, 1808, 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يتحكم فيه بالنسبة للبيوبس التكنيكي ممكن أنا أعمل penetration لزونا بليوسيدا mechanical زي ما احنا شوفنا في الـ assistant hatching و بالفيديو chemical باستخدام بعض المواد الكيميائية وهي عبارة عن مواد في الغالب تكون acidic زي الـ triode acid هذا أخدناها في الـ polar body biopsy إذا في عندي mechanical وفي عندي", "tokens": [9566, 21292, 27884, 2423, 39184, 31588, 78, 5551, 24793, 16490, 1211, 10632, 3714, 29245, 23328, 3660, 8978, 2423, 39184, 31588, 78, 23758, 13672, 1829, 7251, 2655, 5016, 24793, 8978, 3224, 20666, 1863, 35457, 3660, 24976, 21292, 2407, 3555, 3794, 16712, 19452, 1829, 4117, 1829, 3714, 43020, 41850, 5551, 25957, 1211, 35187, 5296, 11622, 2407, 8315, 4724, 20292, 41779, 25708, 995, 12070, 30767, 1829, 19446, 1975, 5016, 8315, 13412, 38688, 8315, 8978, 2423, 39184, 10994, 17387, 278, 4032, 20666, 41185, 16254, 2407, 7313, 4724, 995, 14851, 9778, 3215, 10943, 45030, 11242, 9673, 14407, 3215, 33251, 32640, 1829, 16373, 10632, 37037, 1829, 6225, 3555, 9640, 3660, 18871, 3714, 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"probability": 0.785888671875}, {"start": 1012.8, "end": 1013.06, "word": " is", "probability": 0.93701171875}, {"start": 1013.06, "end": 1013.38, "word": " placed", "probability": 0.796875}, {"start": 1013.38, "end": 1013.68, "word": " back", "probability": 0.85986328125}, {"start": 1013.68, "end": 1013.84, "word": " in", "probability": 0.8837890625}, {"start": 1013.84, "end": 1013.96, "word": " the", "probability": 0.7509765625}, {"start": 1013.96, "end": 1014.28, "word": " culture", "probability": 0.85498046875}, {"start": 1014.28, "end": 1014.72, "word": " media", "probability": 0.89599609375}, {"start": 1014.72, "end": 1015.16, "word": " and", "probability": 0.9462890625}], "temperature": 1.0}, {"id": 43, "seek": 104376, "start": 1015.54, "end": 1043.76, "text": "turned to the incubator where it can be resumed it's normal growth and development طبعا هذه العملية .. عملية ال aspiration بتكون في اليوم التاني .. عفوا في اليوم التالت .. في اليوم الرابع بناء على عدد الخلايا الموجودة 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IVF أو الإجزة يعطيني Healthy Baby بنسبة 100%؟ طبعا للأسف هذه العملية مافيها ضمان So there is no guarantee for PGD to giving a completely healthy baby بنسبة 100% لأنك أنت بتدور على جينات معينة موجودة في العائلة ممكن يصير لحظة من لحظات ال mutation", "tokens": [27842, 11331, 1829, 12984, 2423, 39184, 27274, 9154, 11331, 1829, 12984, 2423, 39184, 426, 1978, 563, 8910, 9154, 11331, 1829, 12984, 2423, 39184, 1300, 2894, 4032, 2423, 39184, 16261, 19446, 41185, 8592, 36632, 37893, 28820, 3660, 8608, 33604, 6027, 6055, 7649, 1829, 8032, 1211, 2423, 39184, 40975, 35, 7251, 10859, 34268, 26890, 48812, 10943, 1863, 36145, 3224, 6055, 1863, 7435, 5016, 6225, 42213, 10632, 2423, 39184, 15967, 37, 34051, 33688, 7435, 11622, 3660, 7251, 3615, 9566, 9957, 1829, 37733, 9425, 4724, 1863, 35457, 3660, 2319, 4, 22807, 23032, 3555, 3615, 995, 24976, 10721, 3794, 5172, 29538, 18863, 42213, 10632, 19446, 41185, 11296, 48812, 2304, 7649, 407, 456, 307, 572, 10815, 337, 40975, 35, 281, 2902, 257, 2584, 4627, 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"seek": 246527, "start": 2437.27, "end": 2465.27, "text": "طبعا chronic villasamling كان exhibited if a baby has chromosomal conditions such as down syndrome and other type of genetic disorder like cystic fibrosis also chronic villasamling can provide viable information about your baby healthy يعني أنا لما أخد عين الدم أو عين نسيجية من ال placenta تحت مصطلح ال chronic villasamling أنا باخد معلومات طبية عن حالة المولود", "tokens": [9566, 3555, 3615, 995, 14493, 4284, 296, 335, 1688, 25961, 49446, 498, 257, 3186, 575, 26824, 298, 304, 4487, 1270, 382, 760, 19371, 293, 661, 2010, 295, 12462, 13399, 411, 48915, 299, 13116, 2635, 271, 611, 14493, 4284, 296, 335, 1688, 393, 2893, 22024, 1589, 466, 428, 3186, 4627, 37495, 22653, 41850, 5296, 15042, 5551, 9778, 3215, 6225, 9957, 32748, 2304, 34051, 6225, 9957, 8717, 3794, 1829, 7435, 10632, 9154, 2423, 20831, 8938, 6055, 33753, 3714, 9381, 9566, 1211, 5016, 2423, 14493, 4284, 296, 335, 1688, 41850, 4724, 47283, 3215, 20449, 1211, 20498, 9307, 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يعني أنا كده أخدت مادة ورثية لها علاقة بالجنين لها علاقة بالجنين what is the purpose of the aminothensis? check the inherited blood disorder like sickle cell anemia, hemophilia, thalassemia muscular skeletal disorder check chromosome abnormality and fetal infection and also we can use it", "tokens": [1829, 33753, 45865, 15844, 45030, 11242, 33962, 15040, 25528, 9673, 2655, 30241, 28671, 20666, 7435, 1863, 9957, 6156, 1211, 2407, 41850, 5551, 9778, 3215, 2655, 6889, 9154, 11296, 41850, 9122, 3215, 3224, 5551, 9778, 3215, 2655, 5438, 4077, 365, 31588, 78, 37495, 22653, 41850, 9122, 3215, 3224, 5551, 9778, 3215, 2655, 3714, 18513, 3660, 4032, 2288, 12984, 10632, 5296, 11296, 11203, 995, 28671, 20666, 7435, 1863, 9957, 5296, 11296, 11203, 995, 28671, 20666, 7435, 1863, 9957, 437, 307, 264, 4334, 295, 264, 669, 259, 900, 694, 271, 30, 1520, 264, 27091, 3390, 13399, 411, 4998, 306, 2815, 364, 14058, 11, 8636, 5317, 24169, 11, 258, 304, 8604, 29958, 31641, 32321, 304, 13399, 1520, 42896, 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"temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 3209.764, "duration_after_vad": 3163.25062499999}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/xq8dGPuJD2c_raw.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/xq8dGPuJD2c_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..6db60c91faf9ae4032af3e7c277cd176fb3759bd
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/xq8dGPuJD2c_raw.srt
@@ -0,0 +1,3056 @@
+1
+00:00:01,300 --> 00:00:05,440
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:05,440 --> 00:00:10,820
+المرسلين سيدنا محمد وعلى آله وصحبه أجمعين طلابنا
+
+3
+00:00:10,820 --> 00:00:15,120
+الأعزاء نرجو من الله الكريم أن تكونوا جميعا بخير
+
+4
+00:00:15,120 --> 00:00:21,520
+اليوم سوف نستكمل ما بدأنا فيه من الجزء السادس من
+
+5
+00:00:21,520 --> 00:00:26,380
+محاضرة التي كانت تتحدث عن عملية ال implantation
+
+6
+00:00:26,380 --> 00:00:31,530
+الخاصة بال embryo بعد نجاح عملية الحقن المجهريوكيف
+
+7
+00:00:31,530 --> 00:00:36,530
+يمكن أن ينتقل الجنين من مكان التلقيح المتمثل في
+
+8
+00:00:36,530 --> 00:00:41,090
+الثلث الأول من قناة fallopian tube وصولا إلى الرحم
+
+9
+00:00:41,090 --> 00:00:47,350
+ثم بعد ذلك الانطلاق في مرحلة انغراس وتكوين المشيمة
+
+10
+00:00:47,350 --> 00:00:51,490
+ثم تحدثنا عن مصطلح جديد وهو عبارة عن ال biopsy
+
+11
+00:00:51,490 --> 00:00:56,470
+الذي يستخدم لتشخيص بعض الأمراض الوراثية التي تنتقل
+
+12
+00:00:56,470 --> 00:01:01,190
+من الأم إلى الأبناء أوبعض الأمراض الوراثية التي
+
+13
+00:01:01,190 --> 00:01:06,730
+لها علاقة بالعائلة ككل ثم سوف ننتقل إلى أنواع أخرى
+
+14
+00:01:06,730 --> 00:01:11,530
+من ال biopsy ولكن في البداية تحدثنا عن نوع واحد من
+
+15
+00:01:11,530 --> 00:01:16,290
+ال biopsy وهي عبارة عن ال polar body biopsy سننتقل
+
+16
+00:01:16,290 --> 00:01:21,550
+للحديث عن ال embryo biopsy و الحديث عن ال PGD و ال
+
+17
+00:01:21,550 --> 00:01:27,790
+sex selection أيضا لأن كلا الموضوعينلهم علاقة
+
+18
+00:01:27,790 --> 00:01:34,470
+كبيرة جدا بعملية الـ embryo biopsy خاصة لعمليات
+
+19
+00:01:34,470 --> 00:01:38,110
+الحقن المجهري وبعض العائلات التي تعاني من أمراض
+
+20
+00:01:38,110 --> 00:01:42,450
+وراثية معينة أو التي تحتاج إلى عمل تحديد جنس
+
+21
+00:01:42,450 --> 00:01:45,510
+للمولود سواء كان يحتاجوا إلى مولود بكر أو مولود
+
+22
+00:01:45,510 --> 00:01:49,650
+أنثى هذا ما سوف نتحدث عنه في محاضرة اليوم إن شاء
+
+23
+00:01:49,650 --> 00:01:54,970
+الله المتعلقة بالجزء السادس أو الشبط الرقم 6 الجزء
+
+24
+00:01:54,970 --> 00:01:59,970
+2لما تحدثنا عن ال polar body تحدثنا إن أنا عندي ال
+
+25
+00:01:59,970 --> 00:02:03,030
+two polar body فممكن أخد ال first polar body وممكن
+
+26
+00:02:03,030 --> 00:02:05,890
+أخد ال second polar body أو ممكن أخد ال two polar
+
+27
+00:02:05,890 --> 00:02:10,410
+body مع بعضهم البعض ومن أشهر أنواع الفحوصات التي
+
+28
+00:02:10,410 --> 00:02:14,370
+يمكن أن تجرى على ال polar body تحت مصطلح polar
+
+29
+00:02:14,370 --> 00:02:17,610
+body biopsy إما فحص ال fish technique وهو ال
+
+30
+00:02:17,610 --> 00:02:21,350
+fluorescent in situ hybridization أو فحص ال PCR
+
+31
+00:02:21,350 --> 00:02:27,000
+وال PCR بشكل أساسي عملية يتم فيها مضاعفةالـ DNA أو
+
+32
+00:02:27,000 --> 00:02:30,660
+ضعفة fragment من الـ DNA إذا أنا ببحث عن جين معين
+
+33
+00:02:30,660 --> 00:02:33,960
+أو defect في جين معين أما ال fluorescent in situ
+
+34
+00:02:33,960 --> 00:02:38,120
+hybridization أنا بدي أعمل targeting ل part معين ل
+
+35
+00:02:38,120 --> 00:02:41,540
+sequence معينة أو لجين معين إذا كنت بدور على
+
+36
+00:02:41,540 --> 00:02:45,760
+defect gene بشكل الكامل هذا المقصود بال
+
+37
+00:02:45,760 --> 00:02:48,900
+fluorescent in situ hybridization و ال PCR أو
+
+38
+00:02:48,900 --> 00:02:54,840
+polymerase chain reactionطبعاً ال transfer عملية
+
+39
+00:02:54,840 --> 00:02:59,320
+ال transfer ل ال embryo عملية تعتبر very critical
+
+40
+00:02:59,320 --> 00:03:04,000
+.. very critical و عملية ال transfer ل ال .. أو ال
+
+41
+00:03:04,000 --> 00:03:07,440
+biopsy خلينا نسميها من منطلق آخر ل ال embryo
+
+42
+00:03:07,440 --> 00:03:12,020
+biopsy أو .. أو polar polar biopsy تعتبر عملية
+
+43
+00:03:12,020 --> 00:03:16,340
+very critical أي خطأ فيها يودي إلى تدمير الجنين
+
+44
+00:03:16,340 --> 00:03:20,550
+بشكل كامل فبالتالي أنا بفقدجنين رغم أنه عملية
+
+45
+00:03:20,550 --> 00:03:24,370
+الحقن أي ال fertilization عملية طبيعية و عملية
+
+46
+00:03:24,370 --> 00:03:27,850
+ناجحة transfer for fluorescent in situ
+
+47
+00:03:27,850 --> 00:03:31,910
+hybridization تختلف اختلافا كليا عن العملية اللي
+
+48
+00:03:31,910 --> 00:03:34,910
+انا بدي استخدم فيها ال PCR يعني لو انا اليوم بدي
+
+49
+00:03:34,910 --> 00:03:40,000
+اعمل fish techniqueعملية نقل الـ polar body تختلف
+
+50
+00:03:40,000 --> 00:03:42,900
+عن عملية نقلها إذا أنا بدي أعمل ال PCR فبالتالي في
+
+51
+00:03:42,900 --> 00:03:46,440
+حالة ال fish technique immediately after biopsy of
+
+52
+00:03:46,440 --> 00:03:49,940
+an oocyte the corresponding polar body are placed
+
+53
+00:03:49,940 --> 00:03:54,080
+in the naporing droplet of the media until the
+
+54
+00:03:54,080 --> 00:03:59,960
+oocyte are biopsied بمعنى إنه أنا مباشرة أنا عشرين
+
+55
+00:03:59,960 --> 00:04:03,140
+بوايدة لعشرين بوايدة بسحب منهم ال polar body و ال
+
+56
+00:04:03,140 --> 00:04:07,840
+polar body بنقلهم إلىقطرة مجاورة للقطرة التي تحتوي
+
+57
+00:04:07,840 --> 00:04:11,140
+على الـ oocyte فبالتالي ماعملش حاجة اسمها
+
+58
+00:04:11,140 --> 00:04:15,020
+separation شو يعني separation؟ يعني ما بقوم بفصل و
+
+59
+00:04:15,020 --> 00:04:18,180
+الله قطرة لل first polar body و قطرة لل second
+
+60
+00:04:18,180 --> 00:04:21,500
+polar body عشان بقول ليه كده بقول ان ال fish
+
+61
+00:04:21,500 --> 00:04:24,280
+technique it is not essentially to place the first
+
+62
+00:04:24,280 --> 00:04:26,660
+polar body and the second polar body in different
+
+63
+00:04:26,660 --> 00:04:30,120
+droplets يعني ممكن أضيفهم مع بعض لإنه حكيت في
+
+64
+00:04:30,120 --> 00:04:32,640
+البداية أن ال first polar body و ال second polar
+
+65
+00:04:32,640 --> 00:04:38,140
+bodyهي عبارة عن مادة وراثية متعلقة بويضة واحدة
+
+66
+00:04:38,140 --> 00:04:42,380
+تعود إلى الأم فأي defect له علاقة بالأم maternal
+
+67
+00:04:42,380 --> 00:04:46,660
+defect فما بحتاج أني أفرق ال polar body الأول عن
+
+68
+00:04:46,660 --> 00:04:50,580
+ال polar body التاني و مجرد بعمل biopsy بحطهم في
+
+69
+00:04:50,580 --> 00:04:54,370
+نفس القطرة أو بنقلهمفي نفس القطرة as they can be
+
+70
+00:04:54,370 --> 00:04:58,810
+visualized during fluorescent evaluation هذا
+
+71
+00:04:58,810 --> 00:05:01,230
+بالنسبة إلى ال polar body و second polar body
+
+72
+00:05:01,230 --> 00:05:06,450
+عملية ال transfer الخاصة فيهم فبالتالي مش مهم عندي
+
+73
+00:05:06,450 --> 00:05:09,710
+أفصل ما بينهم due to small cytoplasmic content of
+
+74
+00:05:09,710 --> 00:05:15,050
+polar body a special pretreatment like hypoosmatic
+
+75
+00:05:15,050 --> 00:05:19,690
+swelling or proteinase treatment prior fish is not
+
+76
+00:05:19,690 --> 00:05:24,440
+necessaryمعنى آخر أن عملية ال fish technique أو
+
+77
+00:05:24,440 --> 00:05:27,440
+الخاصة بالخلينا نسميها أن ال polar body لما نبدأ
+
+78
+00:05:27,440 --> 00:05:30,980
+أعمله fish technique مش لازم أعمل حاجة بتسميها
+
+79
+00:05:30,980 --> 00:05:34,460
+pretreatment قبل ال testing أو pretreatment قبل ال
+
+80
+00:05:34,460 --> 00:05:38,800
+analysis يعني مش مطلوب مني أعمل swelling باستخدام
+
+81
+00:05:38,800 --> 00:05:42,540
+ال hypo osmotic swelling test لل polar body مش
+
+82
+00:05:42,540 --> 00:05:46,470
+مطلوب أعمل ما يُعرف باسم ال proteinaseTreatment لـ
+
+83
+00:05:46,470 --> 00:05:50,610
+Polar Body قبل عملية Fish Technique سبب ببساطة أن
+
+84
+00:05:50,610 --> 00:05:53,750
+كمية الـCytoplasma الموجودة في Polar Body كمية
+
+85
+00:05:53,750 --> 00:05:58,430
+قليلة جدا فهذا يسمح لنا بإجراء الفحص مباشرة دون أي
+
+86
+00:05:58,430 --> 00:06:01,970
+خطوة من خطوات المعالجة قبل عملية الـFish Technique
+
+87
+00:06:01,970 --> 00:06:06,670
+For transfer into the glass slide polar body of
+
+88
+00:06:06,670 --> 00:06:09,410
+one oocyte are removed from their drop and
+
+89
+00:06:09,410 --> 00:06:14,210
+transferred intointo tin drop 0.2ml of water
+
+90
+00:06:14,210 --> 00:06:16,730
+placed on the cleaning glass slide يعني هالوقت
+
+91
+00:06:16,730 --> 00:06:20,750
+بتدبدأ أعمل الفحص باخد واحد من ال polar body بضعه
+
+92
+00:06:20,750 --> 00:06:25,060
+في قطرة تحتوى على 0.2ملي لتر من الماء تقريبا يعني
+
+93
+00:06:25,060 --> 00:06:27,800
+200 ميكرو لتر water خدوا بالكوا لما اقول water
+
+94
+00:06:27,800 --> 00:06:30,920
+يعني ultra pure water في كل شيء له علاقة بال
+
+95
+00:06:30,920 --> 00:06:34,460
+molecular biology او ال emperiology small volume
+
+96
+00:06:34,460 --> 00:06:39,020
+مهم جدا طب ليش انا بستخدم 200 micro أو 0.2 ملي لتر
+
+97
+00:06:39,020 --> 00:06:43,040
+من ال water لأنه مهم جدا فيهالمساعدة للـ Polar
+
+98
+00:06:43,040 --> 00:06:45,520
+Body المساعدة للـ Polar Body ان يصيله Attachment
+
+99
+00:06:45,520 --> 00:06:49,120
+مع الـ Glass خلال عملية الـ Drying طالما انا حطيت
+
+100
+00:06:49,120 --> 00:06:52,080
+200 Micro وضفت فيها الـ Polar Body حسيب هذا الـ
+
+101
+00:06:52,080 --> 00:06:56,980
+GIF عملية الـ Drying تعمل عملية Attachment او
+
+102
+00:06:56,980 --> 00:07:01,820
+Fixation بتشتغل ك Fixation Step أو Fixative Step
+
+103
+00:07:01,820 --> 00:07:05,920
+فتعمل Fixation للـ Polar Body في الـ Glass Slide
+
+104
+00:07:05,920 --> 00:07:09,080
+فبالتالي الـ Polar Body بيصير ثابت اي عملية
+
+105
+00:07:09,080 --> 00:07:12,920
+Removing او Washing بيصير له عمليةdrilling أو
+
+106
+00:07:12,920 --> 00:07:16,600
+removing خلاص صار له عملية attachment مع ال glass
+
+107
+00:07:16,600 --> 00:07:19,880
+slide placing the polar body directly at the
+
+108
+00:07:19,880 --> 00:07:22,860
+bottom of the slide will prevent floating and
+
+109
+00:07:22,860 --> 00:07:25,780
+rupture of the polar body انا وانا برفع ال polar
+
+110
+00:07:25,780 --> 00:07:29,080
+body و بنقله الى القطرة التي تحتوى على 200 micro
+
+111
+00:07:29,080 --> 00:07:34,120
+liter من الماء بكون دائما في بالي ان انا اضع ال
+
+112
+00:07:34,120 --> 00:07:37,600
+polar body في اسفل القطرة مش ارميها على سطح القطرة
+
+113
+00:07:37,600 --> 00:07:43,050
+لأ بده ادخل بال needle في القطرةبتأكد إن أنا وضعته
+
+114
+00:07:43,050 --> 00:07:48,250
+بأقرب مسافة من ال slide علشان هذا بمنع ال polar
+
+115
+00:07:48,250 --> 00:07:51,030
+body أن يصير floating و بيساعد على عملية ال
+
+116
+00:07:51,030 --> 00:07:54,870
+fixation بشكل كبير جدا لأن لو صار عملية floating
+
+117
+00:07:54,870 --> 00:07:59,230
+على ال polar body احتمالية فقدره بتكون أكبر بكثير
+
+118
+00:07:59,230 --> 00:08:02,670
+The drying process must be observed under a
+
+119
+00:08:02,670 --> 00:08:05,350
+stereomicroscope and the final location of the
+
+120
+00:08:05,350 --> 00:08:09,010
+polar body after air dries should be markedبمعنى
+
+121
+00:08:09,010 --> 00:08:13,250
+آخر إن بدي أسرع عملية ال drying باخد ال glass اللي
+
+122
+00:08:13,250 --> 00:08:16,730
+فيها 200 ميكرو ليتر water و اللي ضيفت فيها ال
+
+123
+00:08:16,730 --> 00:08:20,650
+polar body بضيفها أو بوضعها على ال stereo
+
+124
+00:08:20,650 --> 00:08:24,830
+microscope واحد الميكروسكوبات اللتي تستخدم في
+
+125
+00:08:24,830 --> 00:08:28,990
+مختبر الأجنة طبعا بكون ال light معرض إليها مشكلة
+
+126
+00:08:28,990 --> 00:08:32,900
+مباشرةهذا بيعمل نوع من أنواع الحرارة المقبولة التي
+
+127
+00:08:32,900 --> 00:08:36,520
+تساعد على تبخر الماء بسرعة مما يؤدي إلى تسريح
+
+128
+00:08:36,520 --> 00:08:40,840
+عملية ال fixation خلصت عملية ال fixation باستخدام
+
+129
+00:08:40,840 --> 00:08:45,620
+ال heating مع ال drying بقوم بعمل markering لل
+
+130
+00:08:45,620 --> 00:08:49,080
+polar body مكانه بيجب أطلع على ال slide من الأسفل
+
+131
+00:08:49,080 --> 00:08:53,100
+هي مكان ال polar body بعمله markering بوضع دائرة
+
+132
+00:08:53,100 --> 00:08:56,040
+باستخدام marker معين بشرط أن ال marker حتى ال
+
+133
+00:08:56,040 --> 00:08:59,500
+marker اللي يستخدمفي الـ Polar Body أو في الـ
+
+134
+00:08:59,500 --> 00:09:04,300
+Imperium لازم يكونش volatile علشان مايأذيش ال
+
+135
+00:09:04,300 --> 00:09:08,130
+Imperiumخلصنا من طريقة الـ Fixation الأولى،
+
+136
+00:09:08,130 --> 00:09:11,310
+بإمكاننا عمل Fixation تانية من خلال استخدام
+
+137
+00:09:11,310 --> 00:09:16,350
+Methanol Acidic Acid Solution من خلال تركيزه 3
+
+138
+00:09:16,350 --> 00:09:20,790
+Methanol إلى 1 Microliter Acidic Acid يعني ممكن
+
+139
+00:09:20,790 --> 00:09:25,050
+يحضروا 3 Methanol إلى 1 Methanol Acidic Acid أو
+
+140
+00:09:25,050 --> 00:09:30,130
+100 أو 300 إلى 100 يعني المفروض يكون النسبة 3 إلى
+
+141
+00:09:30,130 --> 00:09:35,730
+1 3 Methanol إلى 1 Acidic Acidبقوم بوضع تقريباً 20
+
+142
+00:09:35,730 --> 00:09:40,650
+أو 30 microliter يعني تلاتة ضرب على الـ polar body
+
+143
+00:09:40,650 --> 00:09:45,190
+هذا بعمل عملية fixation لمدة طبعا فترة زمانية
+
+144
+00:09:45,190 --> 00:09:49,510
+معينةتقريباً تلاتين ثانية اربعين ثانية هذا كنوع من
+
+145
+00:09:49,510 --> 00:09:52,850
+أنواع ال fixation رقم اتنين بعد ما يصيله fixation
+
+146
+00:09:52,850 --> 00:09:56,050
+another fixation after air dried using methanol at
+
+147
+00:09:56,050 --> 00:09:58,770
+room temperature for five minutes يعني عملت تلت
+
+148
+00:09:58,770 --> 00:10:01,190
+أنواع من ال fixation fixation الأول باستخدام ال
+
+149
+00:10:01,190 --> 00:10:05,150
+water والdrying fixation التاني باستخدام تلاتة إلى
+
+150
+00:10:05,150 --> 00:10:08,210
+واحد methanol acidic acid وال fixation التالت وهو
+
+151
+00:10:08,210 --> 00:10:12,570
+ال methanol على room temperature خمسة minutes خلصت
+
+152
+00:10:12,570 --> 00:10:17,540
+كدهتحضير الـ Polar Body لعملية الـ Fish Technique
+
+153
+00:10:17,540 --> 00:10:20,580
+بعد كده الـ Fish Technique هو Protocol يعتمد على
+
+154
+00:10:20,580 --> 00:10:23,900
+الشركة اللي أنا ماخد منها الـ Sequence المحمل
+
+155
+00:10:23,900 --> 00:10:29,800
+عليها ال Prob أو ال Die هذا مافيش فيه اي اختلافكيف
+
+156
+00:10:29,800 --> 00:10:33,280
+انا بده اعمل transfer ل ال polar body عشان اعمل
+
+157
+00:10:33,280 --> 00:10:37,320
+PCR؟ طبعا بالنسبة لل polar body ال transfer for
+
+158
+00:10:37,320 --> 00:10:40,320
+PCR ال differentiation of the first and second
+
+159
+00:10:40,320 --> 00:10:43,820
+polar body is very important لما بده اعمل PCR
+
+160
+00:10:43,820 --> 00:10:46,460
+باستخدام المادة الوراثية المتعلقة بال polar body
+
+161
+00:10:46,820 --> 00:10:50,320
+هنا لازم أفصل ال first polar body عن ال second
+
+162
+00:10:50,320 --> 00:10:53,460
+polar body لأن لو ال defect صارت في ال first polar
+
+163
+00:10:53,460 --> 00:10:56,260
+body إلها معنى ال defect صار في ال second polar
+
+164
+00:10:56,260 --> 00:10:59,720
+body إلها معنى تاني يختلف عن المعنى الأولاني
+
+165
+00:10:59,720 --> 00:11:04,900
+فبالتالي هنا معناه أن الخلية أو البوايضة فيها خلل
+
+166
+00:11:04,900 --> 00:11:08,280
+في القسم الميوز الأول هنا البوايضة فيها خلل في
+
+167
+00:11:08,280 --> 00:11:14,240
+القسم الميوز التاني فبالتالي الخلل ممكن يكون مستمر
+
+168
+00:11:14,240 --> 00:11:17,810
+مع الأجيالفمعنى آخر إذا كان في عندي خلال في ال
+
+169
+00:11:17,810 --> 00:11:23,270
+polar body biopsy الأول معناه قد يكون تم تصحيحه
+
+170
+00:11:23,270 --> 00:11:27,090
+عندما تم إنتاج ال polar body التاني أو لم يتم
+
+171
+00:11:27,090 --> 00:11:30,650
+تصحيحه فاللي بأكد هذا الكلامالـ second polar body
+
+172
+00:11:30,650 --> 00:11:34,830
+biopsy فبالتالي في حالة ال PCR لازم افصل ال first
+
+173
+00:11:34,830 --> 00:11:38,070
+polar body عن ال second polar body therefore the
+
+174
+00:11:38,070 --> 00:11:40,570
+first and the second polar body are released after
+
+175
+00:11:40,570 --> 00:11:45,110
+biopsy in the two different droplets و لازم اغطي
+
+176
+00:11:45,110 --> 00:11:47,810
+ال cover بعد ما اضفه في ال droplets الخاص بال
+
+177
+00:11:47,810 --> 00:11:52,070
+media اعمله covering و اغطي ال drops باستخدام
+
+178
+00:11:52,070 --> 00:11:56,720
+mineral oil علشان احافظ على المادة الوراثيةكما هي
+
+179
+00:11:56,720 --> 00:12:01,280
+وحافظ على البولار بادي بدون أي external effect
+
+180
+00:12:01,280 --> 00:12:06,740
+خلصنا من البولار بادي نيجي لقى ال embryo واللي
+
+181
+00:12:06,740 --> 00:12:09,920
+الكل الناس اللي بتشتغل في هذا المجال بتنيل إلى
+
+182
+00:12:09,920 --> 00:12:13,400
+استخدام ال embryo فيبسي في تشخيص الأمراض الوراثية
+
+183
+00:12:13,400 --> 00:12:19,420
+أو تحديد مرض معين إذا كان الطبيب بتبحث عنه طبعا
+
+184
+00:12:19,420 --> 00:12:23,100
+بالنسبة لل embryoهذه عملية ..عملية critical إلى حد
+
+185
+00:12:23,100 --> 00:12:27,900
+ما بشكل كبير جدا لأن أنا مهمتي هنا أخد خلية من وسط
+
+186
+00:12:27,900 --> 00:12:32,000
+تمام الخلايا أو أخد خاليتين من وسط 32 خلية
+
+187
+00:12:32,000 --> 00:12:36,140
+فبالتالي أي خطأ أثناء ال biopsy معناه rupture و
+
+188
+00:12:36,140 --> 00:12:39,660
+destructure لل embryo يعني أنا كده فشلت في أخذ
+
+189
+00:12:39,660 --> 00:12:43,540
+الخزعة وفشلت في إتمام عملية الحقن المجهر إلى
+
+190
+00:12:43,540 --> 00:12:49,000
+النهاية للحصول على true baby فبالتالي مهم جدا أعرف
+
+191
+00:12:49,000 --> 00:12:53,770
+وقت الخزعةوكم خلية اخد هذا مهم جدا اهم two factor
+
+192
+00:12:53,770 --> 00:12:59,330
+لنجاح عملية ال embryo biopsy حكينا في حاجة اسمة
+
+193
+00:12:59,330 --> 00:13:03,790
+Plastomere وهي كل خلية تظهر بعد اليوم الثاني من
+
+194
+00:13:03,790 --> 00:13:08,000
+الانقسان بسميها Plastomereكل خلية أنا باخدها
+
+195
+00:13:08,000 --> 00:13:12,540
+بسميها embryo biopsy Plastomere biopsy or embryo
+
+196
+00:13:12,540 --> 00:13:16,240
+biopsy is a technique that is performed during IVF
+
+197
+00:13:16,240 --> 00:13:20,340
+when an embryo has arrived at the 6th or 8th cell
+
+198
+00:13:20,340 --> 00:13:24,740
+يعني بعد تلت أيام من القسم يعني معنى الكلام أن ال
+
+199
+00:13:24,740 --> 00:13:28,460
+embryo biopsy لها مسمة أخر هي Plastomere biopsy
+
+200
+00:13:28,460 --> 00:13:32,920
+وهي عبارة عن عملية يتم فيها أخذ خلية واحد أو
+
+201
+00:13:32,920 --> 00:13:37,470
+خاليتينمن جنين يحتوي في الأصل على 6 خلايا على
+
+202
+00:13:37,470 --> 00:13:41,410
+الأقل أو 8 خلايا متى بيصير 6 خلايا أو 8 خلايا؟ لأن
+
+203
+00:13:41,410 --> 00:13:45,590
+هذه فترة في اليوم التالت من الإنقسام الهدف الأساسي
+
+204
+00:13:45,590 --> 00:13:48,990
+للإمبيريوبيبسي هو إزالة صفشا من تشو الإمبيريونيك
+
+205
+00:13:48,990 --> 00:13:53,770
+لجيناتك الدياجنوستيك مثلا من أشهر أنواع الجيناتك
+
+206
+00:13:53,770 --> 00:13:58,270
+الدياجنوستيك الحاجة بيسميها pre-genetic أو pre
+
+207
+00:13:58,270 --> 00:14:01,920
+-genetic diagnosticأو خلّينا نسميه Pre
+
+208
+00:14:01,920 --> 00:14:04,080
+-implantation Genetic Diagnostic اللي حاجة نسميه
+
+209
+00:14:04,080 --> 00:14:07,960
+PGD Pre-implantation Genetic Diagnostic و اللي
+
+210
+00:14:07,960 --> 00:14:13,560
+كانت أول مطاردة في عام 1989 كبداية تم فيها تشقيس
+
+211
+00:14:13,560 --> 00:14:17,840
+بعض الأمراض المتصلة بال X-Chromosome سواء كان
+
+212
+00:14:17,840 --> 00:14:20,620
+dominant أو recessive اللي سمينا X-linked disorder
+
+213
+00:14:20,620 --> 00:14:26,320
+أيضا بعد كده استخدموا الامبروبيوتس 4-6 selection
+
+214
+00:14:27,020 --> 00:14:29,420
+الـ Embryo biopsy هي عبارة عن two-step
+
+215
+00:14:29,420 --> 00:14:33,700
+micromanipulation process تشمل الخطواتين الخطوة
+
+216
+00:14:33,700 --> 00:14:37,120
+الأولى تشمل penetration للزونا بليوسيدا أو
+
+217
+00:14:37,120 --> 00:14:40,780
+partially removing للزونا بليوسيدا علشان انا
+
+218
+00:14:40,780 --> 00:14:46,660
+استطيع ان ادخل للخلية بعد كده بعد ما يصير عندي
+
+219
+00:14:46,660 --> 00:14:51,970
+partially penetration للزونا بليوسيدالازم بعد كده
+
+220
+00:14:51,970 --> 00:14:57,270
+اعمل removing ل one cell او two cells من الخلية
+
+221
+00:14:57,270 --> 00:15:01,810
+إذن هي عبارة عن عملية بتتم بخطواتين الخطوة الأولى
+
+222
+00:15:01,810 --> 00:15:04,290
+partial removing for zona pellucida
+
+223
+00:15:07,620 --> 00:15:14,000
+مؤقت الشغلة التانية بشكل جزء خلينا نسميه بعد كده
+
+224
+00:15:14,000 --> 00:15:18,360
+بدخل بال aspiration needle عشان أجي أعمل حاجة
+
+225
+00:15:18,360 --> 00:15:23,660
+بنسميها aspiration أو removing لل one or more one
+
+226
+00:15:23,660 --> 00:15:28,320
+cells طبعا عدد الخلايا أنا مش اللي بتحكم فيه بشكل
+
+227
+00:15:28,320 --> 00:15:32,740
+عام بل بتحكم فيهطبيعة الـ embryo أكم خلية موجودة
+
+228
+00:15:32,740 --> 00:15:35,760
+في الـ embryo هذا اللي يتحكم فيه بالنسبة للبيوبس
+
+229
+00:15:35,760 --> 00:15:39,200
+التكنيكي ممكن أنا أعمل penetration لزونا بليوسيدا
+
+230
+00:15:39,200 --> 00:15:41,860
+mechanical زي ما احنا شوفنا في الـ assistant
+
+231
+00:15:41,860 --> 00:15:46,080
+hatching و بالفيديو chemical باستخدام بعض المواد
+
+232
+00:15:46,080 --> 00:15:49,980
+الكيميائية وهي عبارة عن مواد في الغالب تكون acidic
+
+233
+00:15:49,980 --> 00:15:54,640
+زي الـ triode acid هذا أخدناها في الـ polar body
+
+234
+00:15:54,640 --> 00:15:58,670
+biopsy إذا في عندي mechanical وفي عنديكيميكال وفي
+
+235
+00:15:58,670 --> 00:16:03,070
+عندى الحاجة اللى بنسميها ال laser hatching إن أنا
+
+236
+00:16:03,070 --> 00:16:06,910
+بستخدم طريقة ال laser وإني بعمل firing بدبث معين
+
+237
+00:16:06,910 --> 00:16:10,970
+بعدد معين Plastomera Remove قولنا إيه إيه ال
+
+238
+00:16:10,970 --> 00:16:14,190
+Plastomera؟ حكى إن Plastomera هي كل خلية موجودة
+
+239
+00:16:14,190 --> 00:16:17,670
+داخل ال embryo بعد اليوم التاني the most
+
+240
+00:16:17,670 --> 00:16:20,350
+frequently used method for Plastomera Remove is
+
+241
+00:16:20,350 --> 00:16:24,710
+aspiration هذه هي الطريقة اللى تستخدم بشكل عالميش
+
+242
+00:16:24,710 --> 00:16:29,960
+بط بتدخل بال forceps مثلا و بسحدالبلاستوميرا لأ،
+
+243
+00:16:29,960 --> 00:16:34,340
+هي عبارة عن suction tube أو aspiration needle بدخل
+
+244
+00:16:34,340 --> 00:16:39,700
+داخل البويضة بعد عملية التعرية أو إزالة جزء من الـ
+
+245
+00:16:39,700 --> 00:16:42,660
+zona pellucida من نفس المكان اللي أزلت منه zona
+
+246
+00:16:42,660 --> 00:16:46,140
+pellucida بدخل بال aspiration needle وبعمل
+
+247
+00:16:46,140 --> 00:16:50,580
+aspiration or suction ل one or two cell after
+
+248
+00:16:50,580 --> 00:16:53,380
+remove the cell, the developed embryo is placed
+
+249
+00:16:53,380 --> 00:16:56,800
+back in the culture media andturned to the
+
+250
+00:16:56,800 --> 00:16:59,760
+incubator where it can be resumed it's normal
+
+251
+00:16:59,760 --> 00:17:02,440
+growth and development طبعا هذه العملية .. عملية
+
+252
+00:17:02,440 --> 00:17:05,120
+ال aspiration بتكون في اليوم التاني .. عفوا في
+
+253
+00:17:05,120 --> 00:17:08,100
+اليوم التالت .. في اليوم الرابع بناء على عدد
+
+254
+00:17:08,100 --> 00:17:10,940
+الخلايا الموجودة داخل الجنين بعد ما أخد الخلايا
+
+255
+00:17:10,940 --> 00:17:14,320
+المطلوبة .. الخلية أو التنتين مباشرة برجع الجنين
+
+256
+00:17:14,320 --> 00:17:17,380
+في ال petri dish أو عفوا برجع الجنين الموجود في ال
+
+257
+00:17:17,380 --> 00:17:22,060
+petri dish كله في ال petri dish الموجود كامل ك one
+
+258
+00:17:22,060 --> 00:17:26,670
+unit في ال incubatorوبسمح للجنين إنه في هذه اللحظة
+
+259
+00:17:26,670 --> 00:17:32,150
+يستكمل عملية نموه وانقسامه عشان يصل إلى 16 خلية و
+
+260
+00:17:32,150 --> 00:17:38,510
+2 تلاتية خلية و يصل لمرحلة الموريلا أيضا هذه الشكل
+
+261
+00:17:38,510 --> 00:17:44,690
+اللي أنا بقصده في الخطوة الأولى عملت عملية holding
+
+262
+00:17:44,690 --> 00:17:52,700
+ل ال embryo بتكون من 1,2,3,4,5,6 حوالي 6 خلاياعملت
+
+263
+00:17:52,700 --> 00:17:55,980
+له holding في ال holder طيبت بعدين دخلت بال needle
+
+264
+00:17:55,980 --> 00:17:59,440
+عشان أعمل حاجة بنسميها mechanical zoonapelucida
+
+265
+00:17:59,440 --> 00:18:04,300
+removing أو mechanical hatching بعد كده حكيت أنه
+
+266
+00:18:04,300 --> 00:18:08,400
+بعمل releasing إلها من ال holder tube و باخدها و
+
+267
+00:18:08,400 --> 00:18:13,440
+بحك أو بعمل عملية احتكاك بسيط في أسفل ال holder
+
+268
+00:18:13,440 --> 00:18:16,300
+tube علشان أعمل removing لهذه المنطقة
+
+269
+00:18:19,740 --> 00:18:22,800
+طبعا بعد ما أعمل removing بدخل بال aspiration
+
+270
+00:18:22,800 --> 00:18:28,340
+needle و بعمل aspiration ل one tube إذن في هذه
+
+271
+00:18:28,340 --> 00:18:31,860
+العملية يتم عمل partial removing للـ zona
+
+272
+00:18:31,860 --> 00:18:36,080
+pellucida كما هو موضح في الصورة الأولى ثم بعد ذلك
+
+273
+00:18:36,080 --> 00:18:40,080
+الدخول بال aspiration needle من المنطقة التي تم
+
+274
+00:18:40,080 --> 00:18:43,360
+عمل فيها partial removing للـ zona pellucida و عمل
+
+275
+00:18:43,360 --> 00:18:48,460
+suction أو aspiration ل one cell من الblastomera
+
+276
+00:18:48,460 --> 00:18:53,380
+الموجودةهذا بالنسبة لعملية الـ Empyrean biopsy
+
+277
+00:18:53,380 --> 00:18:59,500
+سؤال مهم بالنسبة لـ Empyrean biopsy شو أهم عوامل
+
+278
+00:18:59,500 --> 00:19:03,280
+بتتحكم فيها؟ أقول إن الـ timing متى أعمل زونة
+
+279
+00:19:03,280 --> 00:19:07,200
+بليستر removing أو متى أعمل Empyrean biopsy في أي
+
+280
+00:19:07,200 --> 00:19:11,840
+يوم وعدد الخلايا اللي أنا جادر أخدها فبالتالي ال
+
+281
+00:19:11,840 --> 00:19:14,820
+timing of biopsy domestically Vigestige biopsy
+
+282
+00:19:14,820 --> 00:19:18,360
+taking place on the third morning followed of
+
+283
+00:19:18,520 --> 00:19:23,080
+Insemination بمعنى آخر انه انا في معظم الحالات لو
+
+284
+00:19:23,080 --> 00:19:25,980
+بدي اعمل embryo biopsy بدي اعملها في اليوم التالت
+
+285
+00:19:25,980 --> 00:19:30,340
+من عملية الاجزي يعني بمعنى آخر لو صارت عملية ال
+
+286
+00:19:30,340 --> 00:19:35,260
+injection في اليوم الأول و هو يوم السبت السبت خلص
+
+287
+00:19:35,260 --> 00:19:39,260
+الأحد يوم الأثنين ممكن ابدأ اعمل embryo biopsy
+
+288
+00:19:39,260 --> 00:19:43,620
+وهذا ال protocol معظم مختبرات الاجزي او مختبرات ال
+
+289
+00:19:43,620 --> 00:19:47,100
+IVF ال IVF بتعتمد عليه انه في اليوم التالت هو
+
+290
+00:19:47,100 --> 00:19:52,660
+اليوماللي مفضل لعمل ال biopsy طبعاً لما نبدأ أجي
+
+291
+00:19:52,660 --> 00:19:57,740
+أعمل biopsy مهم جدا أن بعضهم بيعمل biopsy في اليوم
+
+292
+00:19:57,740 --> 00:20:01,500
+الأول فبالتالي إذا كانت النتيجة بتحتاج إلى فترة
+
+293
+00:20:01,500 --> 00:20:05,400
+زمنية طويلة جدا يومين أو تلاتة علشان تطلع عن نتيجة
+
+294
+00:20:05,400 --> 00:20:09,980
+نتيجة ال genetic testing فبرجع في اليوم الخامس
+
+295
+00:20:09,980 --> 00:20:13,700
+والله إذا كان النتيجة بتطلع خلال 24 ساعة برجع في
+
+296
+00:20:13,700 --> 00:20:19,270
+اليومالرابع يعني مهم جدا ان عملية الترجية تحدث بعد
+
+297
+00:20:19,270 --> 00:20:23,290
+يومين كحد اقصى او تلاتة كحد اقصى من عملية ال
+
+298
+00:20:23,290 --> 00:20:25,610
+embryo biopsy اذا انا عملت ال embryo biopsy في
+
+299
+00:20:25,610 --> 00:20:29,470
+اليوم التالت في اليوم التالت من عملية ال
+
+300
+00:20:29,470 --> 00:20:34,170
+insemination النقطة التانية المهمة جدا ال number
+
+301
+00:20:34,170 --> 00:20:38,410
+of cells اكمل Plastomere انا ممكن اخد من الbiopsy
+
+302
+00:20:38,410 --> 00:20:45,610
+او من ال embryo هذاأكم او أكم cells موجودة داخل ال
+
+303
+00:20:45,610 --> 00:20:50,630
+embryo هاي موجود 6 موجود 8 موجود 16 موجود 32 كل ما
+
+304
+00:20:50,630 --> 00:20:54,110
+زاد عدد الخلايا كل ما كان عندي إمكانية أن أاخد
+
+305
+00:20:54,110 --> 00:21:00,410
+بيبسي 2 و 3 و 4 فهذا مهم جدا في معظم أو العديد من
+
+306
+00:21:00,410 --> 00:21:04,770
+مختبرات ال IVF بيعتوا second blastomera is removed
+
+307
+00:21:04,770 --> 00:21:10,270
+from embryo having 7 or more cellsيعني أي embryo
+
+308
+00:21:10,270 --> 00:21:14,870
+بيحتوي على ستة أو سبع خلايا أو أكتر كل المختبرات
+
+309
+00:21:14,870 --> 00:21:17,630
+أو عدد خليني أسميها من المختبرات بياخد خليتين يعني
+
+310
+00:21:17,630 --> 00:21:21,650
+بياخد two blastomeras و بيخضعهم لل genetic testing
+
+311
+00:21:21,650 --> 00:21:25,890
+بعضهم لأ بياخد واحدة بقولك لأنه بعض الدراسات جلت
+
+312
+00:21:25,890 --> 00:21:29,350
+أنه كل ما زاد عدد ال pipes المأخوذة كل ما كانت لها
+
+313
+00:21:29,350 --> 00:21:33,950
+تأثير سلبي على تطور و نمو الجديد في بعض الأحيان أو
+
+314
+00:21:33,950 --> 00:21:37,740
+بعض الدراسات جلت لأ مافيش منه الكلام هذالأن الجنين
+
+315
+00:21:37,740 --> 00:21:42,660
+قادر إنه ينمو ويتأقلم على الوضع الجديد فبالتالي
+
+316
+00:21:42,660 --> 00:21:49,220
+القرار الأساسي اللي بحكمني أكم بيوبسي أخد أو أكم
+
+317
+00:21:49,220 --> 00:21:54,660
+Plastomere أخد واحدة أو تنتين يعتمد على عدة عوامل
+
+318
+00:21:54,660 --> 00:21:57,860
+العامل الأول الـ embryo cell number أكم خلية
+
+319
+00:21:57,860 --> 00:22:02,780
+موجودة داخل ال embryo والشغل التاني ال testing
+
+320
+00:22:02,780 --> 00:22:05,660
+اللي أنا بدي أعمله و ال diagnostic اللي بدي أعمله
+
+321
+00:22:05,920 --> 00:22:09,280
+أنا ماحتاج جداش كمية من المادة الوراثية يعني مش
+
+322
+00:22:09,280 --> 00:22:13,760
+منطقي و الله انا بدي اعمل خمس فحوصات وراثية فال
+
+323
+00:22:13,760 --> 00:22:18,100
+one embryo او one biopsy او one plasomera الكمية
+
+324
+00:22:18,100 --> 00:22:21,560
+المادة الوراثية الموجودة فيها لن تكفي فمش منطقي
+
+325
+00:22:21,560 --> 00:22:25,060
+اروح اعمل بس اتنين واسيب الخمسة او باجد الخمس
+
+326
+00:22:25,060 --> 00:22:27,880
+فحوصات المطلوبة ففي نفس اللحظة باخد اتنين
+
+327
+00:22:27,880 --> 00:22:31,600
+plasomera او تلاتة plasomera علشان اضمن ان الكمية
+
+328
+00:22:31,600 --> 00:22:35,550
+المتوفرة لدي من المادة الوراثية الخاصة بالجنينتكفي
+
+329
+00:22:35,550 --> 00:22:40,490
+لعمل جميع الفحوصات الوراثية المطلوبة remove of two
+
+330
+00:22:40,490 --> 00:22:44,030
+cells should only be considered one embryo with
+
+331
+00:22:44,030 --> 00:22:47,770
+six or more cells يعني keep it in your mind as
+
+332
+00:22:47,770 --> 00:22:53,450
+note ان عزل خلية واحدة plus تميرة او خليتين يجب ان
+
+333
+00:22:53,450 --> 00:22:58,090
+تكون او تحدث على امبريو يحتوي على الأقل ست خلايا
+
+334
+00:22:58,090 --> 00:23:02,950
+اول الفحوصات اللي انا ممكن اشتغلها فحص بنسمي ال
+
+335
+00:23:02,950 --> 00:23:08,720
+BGD وهوimplantation genetic testing من اسمه تشخيص
+
+336
+00:23:08,720 --> 00:23:14,720
+جيني قبل الإنغراس أو قبل الجرجعة وهو أحد الفحوصات
+
+337
+00:23:14,720 --> 00:23:19,280
+الوراثية المنتشرة في المراكز التحقن المجهري أو
+
+338
+00:23:19,280 --> 00:23:23,680
+التلقيح الصناعي والتي تعتمد على تشخيص أمراض معينة
+
+339
+00:23:23,680 --> 00:23:29,040
+لها علاقة بعائلة معينة يعني بمعنى آخر زي
+
+340
+00:23:29,040 --> 00:23:31,340
+الهموفيليا منتشرة في عائلة معينة ال sickle cell
+
+341
+00:23:31,340 --> 00:23:34,630
+منتشرة في عائلة معينةالأنيميا بأنواعها متشرة في
+
+342
+00:23:34,630 --> 00:23:39,450
+بعض العائلات فبدي أنا أرجّق جنين هذا الجنين لا
+
+343
+00:23:39,450 --> 00:23:43,990
+يحمل الجين المسؤول عن المرض يعني جنين normal بنسبة
+
+344
+00:23:43,990 --> 00:23:47,630
+كبيرة جدا during PGD the genetic analysis is done
+
+345
+00:23:47,630 --> 00:23:51,490
+for of the single cell from 8 cell embryo نفس
+
+346
+00:23:51,490 --> 00:23:54,930
+القصة يقول إن أنا بعمل analysis للمادة الوراثية
+
+347
+00:23:54,930 --> 00:23:58,730
+المأخوذة من خلية واحدة من ال embryo يحتوي على 8
+
+348
+00:23:58,730 --> 00:24:02,390
+خلاياعشان كده قلنا فيما سبق أنه أقل شيء من 6 إلى 7
+
+349
+00:24:02,390 --> 00:24:05,830
+خلايا هو الجنين المسموح له يخضع للـ Empyrean
+
+350
+00:24:05,830 --> 00:24:10,510
+Biopsy الـ PGD هي عبارة عن الـ procedure تحدث بعد
+
+351
+00:24:10,510 --> 00:24:14,870
+عملية ال fertilization وتحدث قبل عملية ال
+
+352
+00:24:14,870 --> 00:24:18,610
+implantation وهذا أمر طبيعي جدا جدا عشان أنا أشخص
+
+353
+00:24:18,610 --> 00:24:22,730
+أي defect في المادة الوراثية المتعلقة بالجنين وليس
+
+354
+00:24:22,730 --> 00:24:25,890
+المتعلقة بالأب والأم لأن هذه المادة الوراثية الـ
+
+355
+00:24:25,890 --> 00:24:30,810
+Plastomereهي مادة وراثية خاصة بالجنين كحد عام أو
+
+356
+00:24:30,810 --> 00:24:36,090
+بشكل خاص جدا الـ PGD لا يُعتبر therapeutic
+
+357
+00:24:36,090 --> 00:24:40,650
+procedure بمعنى آخر إنه أنا برغم إنه عملت PGD ما
+
+358
+00:24:40,650 --> 00:24:45,430
+في عندي جارانتي إنه الطفل المرجع يكون سالم بنسبة
+
+359
+00:24:45,430 --> 00:24:49,530
+100% يكون سليم بنسبة 100% فبالتالي
+
+360
+00:24:54,410 --> 00:24:58,830
+مادة أو عملية الـ BGD هي عبارة عن عملية تشخيصية
+
+361
+00:24:58,830 --> 00:25:03,530
+محظة بالشكل الأول ومن الدرجة الأولى لا تعتبر عملية
+
+362
+00:25:03,530 --> 00:25:07,410
+علاجية لأنه لا يتم حدوث تغير في المادة الوراثية
+
+363
+00:25:07,410 --> 00:25:12,090
+المتعلقة بالجنين ما بدخل جين مقابل جين هذا إشي
+
+364
+00:25:12,090 --> 00:25:17,810
+تاني طبعا الـ BGD مرت بتسميات مختلفة منها الـ BGT
+
+365
+00:25:17,810 --> 00:25:21,050
+وهي الـ Preimplantation Genetic Testing بعد أن
+
+366
+00:25:21,050 --> 00:25:26,980
+تطورت إلى تشخيص أنبلودي فسموهاBGT-A يعني بلودي بعد
+
+367
+00:25:26,980 --> 00:25:30,600
+ان اتطورت الى الـ BGT-M اللي لها علاقة بالـ Single
+
+368
+00:25:30,600 --> 00:25:33,760
+Gene Defect أو الـ Monogenetic بعد ان اتطورت الى
+
+369
+00:25:33,760 --> 00:25:36,880
+الـ BGT-SR اللي لها علاقة بالـ Structure
+
+370
+00:25:36,880 --> 00:25:42,140
+Rearrangement فبالاصل هي عبارة عن BGT or BGT بناء
+
+371
+00:25:42,140 --> 00:25:46,420
+على ماذا تستخدم أو لماذا تستخدم أو في ماذا تستخدم
+
+372
+00:25:46,790 --> 00:25:50,110
+إذا كانت تستخدم لتشخيص الانبلودي، بضيف حرف A إذا
+
+373
+00:25:50,110 --> 00:25:53,050
+كانت تستخدم لتشخيص الـ monogenetic أو single gene
+
+374
+00:25:53,050 --> 00:25:57,190
+defect، بضيف M إذا كانت تستخدم لتشخيص الكرومزومة
+
+375
+00:25:57,190 --> 00:26:01,950
+الـ Structural Rearrangement بضيف BGTSR Single
+
+376
+00:26:01,950 --> 00:26:06,190
+Structural Rearrangement مين ممكن يستفيد من الـ
+
+377
+00:26:06,190 --> 00:26:11,120
+BGT؟ عدةحالات ممكن تستفيد من الـ BGD أول حالة ان
+
+378
+00:26:11,120 --> 00:26:16,660
+الكابلز اللي عندهم career for sex link disorder او
+
+379
+00:26:16,660 --> 00:26:19,360
+genetic disorder اللي بنسميه sex link genetic
+
+380
+00:26:19,360 --> 00:26:22,940
+disorder الكاريار لل single gene disorder الناس
+
+381
+00:26:22,940 --> 00:26:25,720
+اللي عندهم الكرموزومة الأبطول مالتيال women اللي
+
+382
+00:26:25,720 --> 00:26:29,300
+عمرها أكتر من 38 سنة لإن عرض ال structure
+
+383
+00:26:29,300 --> 00:26:33,100
+rearrangement بتكون أكتر ال chance لظهورها ال
+
+384
+00:26:33,100 --> 00:26:38,260
+women have severe .. or several خلينا نسميها
+
+385
+00:26:38,260 --> 00:26:42,900
+miscarriage السيدات اللي عندهم pregnancy lose بشكل
+
+386
+00:26:42,900 --> 00:26:46,860
+مستمر السيدات اللي عندهم chromosomal abnormality
+
+387
+00:26:46,860 --> 00:26:51,940
+بشكل واضحو تم تشخيصهم بالـ chromosomal abnormality
+
+388
+00:26:51,940 --> 00:26:55,080
+بشكل واضح قبل عملية الحمل فبالتالي ممكن هذه الحالة
+
+389
+00:26:55,080 --> 00:26:59,820
+تنتقل للجنين فبالتالي بعمل BGD للجنين علشان أتأكد
+
+390
+00:26:59,820 --> 00:27:03,980
+أن هذه الحالة مش موجودة عنده أيضا ال BGD ممكن
+
+391
+00:27:03,980 --> 00:27:08,040
+أستخدمها لل sex selection ال BGD ممكن أعملها لل
+
+392
+00:27:08,040 --> 00:27:11,440
+balancing for sex يعني بدي family تبتعد من اتنين
+
+393
+00:27:11,440 --> 00:27:15,480
+ذكور اتنين اناف هذا ما يسمى balanceالـ PGD ممكن
+
+394
+00:27:15,480 --> 00:27:20,100
+تحدث للـ couples اللي عندهم IVF فاليار أكتر من تلت
+
+395
+00:27:20,100 --> 00:27:25,740
+مرات man with some of sperm abnormality سواء كانت
+
+396
+00:27:25,740 --> 00:27:28,800
+عنده sperm abnormality في الـ head في الميتاكندرية
+
+397
+00:27:28,800 --> 00:27:34,580
+في الـ chromatin abnormality في الكرومزوم
+
+398
+00:27:34,580 --> 00:27:38,560
+كوندنسيشن هذه كلها ممكن أنا أستخدم PGD عشان أتأكد
+
+399
+00:27:38,560 --> 00:27:41,700
+أن الحالة المرضية مش موجودة الـ Unexplained
+
+400
+00:27:41,700 --> 00:27:45,340
+infertility ممكن أستخدم فيها PGDY chromosome
+
+401
+00:27:45,340 --> 00:27:50,560
+deletion found in 5-10% of male with those pair
+
+402
+00:27:50,560 --> 00:27:54,180
+count يعني ممكن انا اعمل Y chromosome deletion او
+
+403
+00:27:54,180 --> 00:27:58,740
+micro deletion باستخدام ال BGD صحيح ممكن ان اشوف
+
+404
+00:27:58,740 --> 00:28:01,420
+ال chromosome هذا او ال micro deletion الخاصة
+
+405
+00:28:01,420 --> 00:28:05,240
+بالchromosome Y موجودة في ال embryo خاصة اذا كان
+
+406
+00:28:05,240 --> 00:28:08,340
+ال embryo طبعا male اذا كان الجينات المسؤولة عن
+
+407
+00:28:08,340 --> 00:28:11,780
+ظهور ال reproductive system for male موجودة في ال
+
+408
+00:28:11,780 --> 00:28:15,580
+embryoأو الجينات المسؤولة عن الـ spermatogenesis
+
+409
+00:28:15,580 --> 00:28:18,820
+موجودة في الـ embryo فبالتالي هذا الـ embryo
+
+410
+00:28:18,820 --> 00:28:23,660
+هيتحول لميل فيما بعد فبالتالي ممكن أنا أبحث عن ال
+
+411
+00:28:23,660 --> 00:28:27,480
+micro deletion أو بنسميها Y كرمزوم micro deletion
+
+412
+00:28:27,480 --> 00:28:31,160
+abnormality إذا موجودة و لا مش موجودة و خاصة في
+
+413
+00:28:31,160 --> 00:28:35,000
+الميل اللي عندهم low sperm count اللي سمناها
+
+414
+00:28:35,000 --> 00:28:40,020
+Oligosperm هنعرف إيش يعني ما هي الجينات المحمولة
+
+415
+00:28:40,020 --> 00:28:44,500
+على ال Y كرمزومأول الفحوصات التي يمكن أن تشخص
+
+416
+00:28:44,500 --> 00:28:48,380
+باستخدام الـ BGD فحص بنسميه الـ Anplody الـ
+
+417
+00:28:48,380 --> 00:28:52,960
+Anplody و أكيد كلنا بنعرفها هي عبارة عن وجود مشكلة
+
+418
+00:28:52,960 --> 00:28:56,720
+في عدد الكرمزومات وجود مشكلة في عدد الكرمزومات
+
+419
+00:28:56,720 --> 00:29:00,240
+يعني عدد الكرمزومات مش طبيعي سواء هذه المشكلة
+
+420
+00:29:00,240 --> 00:29:03,120
+زيادة في عدد الكرمزومات بالكرمزوم واحد أو اتنين أو
+
+421
+00:29:03,120 --> 00:29:06,880
+نقصان في عدد الكرمزومات بالكرمزوم واحد او اتنين أو
+
+422
+00:29:06,880 --> 00:29:12,110
+أكتر أو أقل هذا بنسميها Anplody زيادة أو نقصانتؤدي
+
+423
+00:29:12,110 --> 00:29:16,310
+إلى اختلاف في عدد الكروموزوم يعني abnormality in
+
+424
+00:29:16,310 --> 00:29:19,770
+the number of chromosomes Anaploidy occur during
+
+425
+00:29:19,770 --> 00:29:22,930
+cell division when the chromosomes don't separated
+
+426
+00:29:22,930 --> 00:29:26,870
+probably between the two cells يعني الهدف الأساسي
+
+427
+00:29:26,870 --> 00:29:31,010
+أو السبب الأساسي من ال Anaploidy يعبر عن خلل في
+
+428
+00:29:31,010 --> 00:29:34,130
+انقسام الخلية عندما في مرحلة من مراحل الخلية
+
+429
+00:29:34,130 --> 00:29:38,680
+وخصوصا في مرحلة الانافيزإنه بيصير عندي فصل
+
+430
+00:29:38,680 --> 00:29:42,780
+للكرمزومة عن بعض البعض بشكل غير صحيح فخلية بتاخد
+
+431
+00:29:42,780 --> 00:29:46,560
+عدد زيادة وخلية بيكون فيها عدد ناقص من الكرمزومة
+
+432
+00:29:46,560 --> 00:29:49,380
+الـ Abnormality most frequently caused of
+
+433
+00:29:49,380 --> 00:29:53,380
+spontaneous abortion بناء على دراسات معينة يوجد
+
+434
+00:29:53,380 --> 00:29:58,960
+عديد من الأشكال المتعلقة بالأنبلودي زي تريزوم 21،
+
+435
+00:29:58,960 --> 00:30:05,010
+تريزوم 18، الادوارووالـ Trisomy 13 كمان من أشهر
+
+436
+00:30:05,010 --> 00:30:07,910
+أنواع الانبلودي طبعاً في انبلودي كتير بس احنا
+
+437
+00:30:07,910 --> 00:30:12,710
+مانشوفهاش لإنه بيصيلها defect قبل الميلاد The
+
+438
+00:30:12,710 --> 00:30:16,810
+impact of a chromosome abnormality شو بتأثر أو على
+
+439
+00:30:16,810 --> 00:30:19,190
+شو بتأثر الكرمزومات abnormality؟ شو ال influence
+
+440
+00:30:19,190 --> 00:30:22,510
+تبعتها؟ بتأثر على .. بتؤدي إلى .. خلّيني أسمي أو
+
+441
+00:30:22,510 --> 00:30:25,770
+تأثيرها يؤدي إلى decrease في ال embryo transfer
+
+442
+00:30:25,770 --> 00:30:29,490
+طالما أنا عندي خمسة embryo في عندهم تلاتة embryo
+
+443
+00:30:31,100 --> 00:30:34,160
+فبالتالي مش منطق ارجعهم و انا اكتشفت ان فيهم عندهم
+
+444
+00:30:34,160 --> 00:30:37,760
+انبلوه دي فبرجع اتنين فصار عندي reduction في ال
+
+445
+00:30:37,760 --> 00:30:41,900
+rate of embryo transfer implantation failure ممكن
+
+446
+00:30:41,900 --> 00:30:46,860
+تصير في عندي pregnancy loss بشكل مستمر وارد او
+
+447
+00:30:46,860 --> 00:30:51,780
+miscarriage في عندي birth defect ممكن الطفل يولد و
+
+448
+00:30:51,780 --> 00:30:57,080
+هو ميت maternal and physical problem in offspring
+
+449
+00:30:57,080 --> 00:31:02,210
+ممكن الأجيالالجيل يورّف الـ abnormality للجيل
+
+450
+00:31:02,210 --> 00:31:06,430
+التاني فبتبقى سما غاهرة في هذه العائلة هذه كلها
+
+451
+00:31:06,430 --> 00:31:10,590
+تعتبر the impact of a chromosome abnormality سؤال
+
+452
+00:31:10,590 --> 00:31:14,330
+بيطرح نفسه هل ال PGD safe على ال embryo أم بيعمل
+
+453
+00:31:14,330 --> 00:31:17,650
+defect لل embryo؟ والله معظم .. معظم المقالات اللي
+
+454
+00:31:17,650 --> 00:31:20,930
+قرأناها و معظم المراجع العلمية الحديثة والقديمة
+
+455
+00:31:20,930 --> 00:31:25,610
+تقول أن ال PGD يعتبرvery safe عن ال embryo لأن ال
+
+456
+00:31:25,610 --> 00:31:29,170
+embryo زي ما حكينا يستطيع ان يتأقلم على الوضع
+
+457
+00:31:29,170 --> 00:31:33,410
+الجديد بسرعة وتستمر عملية النمو المتعلقة فيه
+
+458
+00:31:33,410 --> 00:31:38,570
+فبالتالي ال BGD safe بشكل كبير جدا evaluation of
+
+459
+00:31:38,570 --> 00:31:41,570
+children born after BGD does not show any
+
+460
+00:31:41,570 --> 00:31:48,230
+indication for a determinal effect of the process
+
+461
+00:31:48,230 --> 00:31:51,190
+of new growth or neurological development والدليل
+
+462
+00:31:51,190 --> 00:31:57,380
+ان دراسةدراسة عملت scanning على ال embryo أو على
+
+463
+00:31:57,380 --> 00:32:01,680
+الأطفال اللي أجوا من embryo اتعرض لل PGD فوجدوا
+
+464
+00:32:01,680 --> 00:32:05,800
+أنه ما عندهم أي مشكلة في عملية النمو ما عندهم أي
+
+465
+00:32:05,800 --> 00:32:11,540
+مشكلة في أيضا المشاكل اللي لها علاقة بالأعصاب و
+
+466
+00:32:11,540 --> 00:32:15,220
+التي تعمل على إيقاف ال development فبالتالي أنجبت
+
+467
+00:32:15,220 --> 00:32:20,960
+الأطفال التي أتت من أجنة خضعت لل PGD بشكل طبيعي من
+
+468
+00:32:20,960 --> 00:32:23,940
+حيث النمومن حيث الـ Intelligence من حيث الـ
+
+469
+00:32:23,940 --> 00:32:26,680
+Nervous System من حيث الـ Reaction و الـ Action
+
+470
+00:32:26,680 --> 00:32:31,420
+مافيش أي مشكلة سؤال تاني هل الـ PGD يُعتبر ضامن
+
+471
+00:32:31,420 --> 00:32:34,580
+إنه تنجح عملية الـ IVF أو الإجزة يعطيني Healthy
+
+472
+00:32:34,580 --> 00:32:38,460
+Baby بنسبة 100%؟ طبعا للأسف هذه العملية مافيها
+
+473
+00:32:38,460 --> 00:32:43,580
+ضمان So there is no guarantee for PGD to giving a
+
+474
+00:32:43,580 --> 00:32:47,380
+completely healthy baby بنسبة 100% لأنك أنت بتدور
+
+475
+00:32:47,380 --> 00:32:50,640
+على جينات معينة موجودة في العائلة ممكن يصير لحظة
+
+476
+00:32:50,640 --> 00:32:54,910
+من لحظات ال mutationيعطيك طفرة تعطيك مرض جديد وارد
+
+477
+00:32:54,910 --> 00:32:59,110
+أو يصير الحملية تتخلص بسبب external factor ل
+
+478
+00:32:59,110 --> 00:33:03,030
+الجنين فيصير اندي a portion وارد فبالتالي مافي
+
+479
+00:33:03,030 --> 00:33:07,290
+حاجة اسمها guarantee بنسبة 100% so no there is
+
+480
+00:33:07,290 --> 00:33:09,910
+many different factors can be affected in the
+
+481
+00:33:09,910 --> 00:33:14,650
+chance of IVF successful or success transferring
+
+482
+00:33:14,650 --> 00:33:18,190
+an embryo that have undergone PGD does not
+
+483
+00:33:18,190 --> 00:33:22,350
+guarantee a pregnancy or a healthy baby حوالي3 إلى
+
+484
+00:33:22,350 --> 00:33:27,510
+5% كل pregnancy كل حالة حمل في عندها 3 إلى 5% as
+
+485
+00:33:27,510 --> 00:33:32,790
+risk for baby lose or defect يعني كل سيدة بتحمل
+
+486
+00:33:32,790 --> 00:33:37,730
+حمل معين عندها احتمالية فقدان الجنين بمعدل 3 إلى 5
+
+487
+00:33:37,730 --> 00:33:42,250
+% يعني بمعنى أخر عندي خمس سيدات بيصير عندهم حمل
+
+488
+00:33:42,250 --> 00:33:47,270
+ممكن يصير عندهم فقدان للجنين فقدان للجنين so what
+
+489
+00:33:47,270 --> 00:33:50,680
+is the advantage of PGDالـ PGD له عدة advantages
+
+490
+00:33:50,680 --> 00:33:53,480
+إنه بعمل لـ improved للـ embryo selection لأن ما
+
+491
+00:33:53,480 --> 00:33:57,000
+برجع إلا للـ embryo اللي واثق إن هذا المرض الوراثي
+
+492
+00:33:57,000 --> 00:34:00,400
+مش موجود بناء على ال data الموجودة عليه بعمل
+
+493
+00:34:00,400 --> 00:34:06,080
+reduction أو decline لمعدل نقل الأجنة التي تحتوى
+
+494
+00:34:06,080 --> 00:34:10,040
+على تشوّق قبل ال implantation بعمل عملية reduction
+
+495
+00:34:10,040 --> 00:34:12,940
+for transfer of embryo that will lead to pregnancy
+
+496
+00:34:12,940 --> 00:34:17,700
+loss فبالتاليمعدل فقدان الجنين معدل ال up portion
+
+497
+00:34:17,700 --> 00:34:21,360
+معدل ال spontaneous up portion بقل لإن أنا برجع
+
+498
+00:34:21,360 --> 00:34:26,240
+الجنين السليم برجع الجنين الحيوي إلى حد ما reduce
+
+499
+00:34:26,240 --> 00:34:30,420
+the financial responsibility طبعا خد بالك أنه معنى
+
+500
+00:34:30,420 --> 00:34:34,640
+جنين فقد أو جنين تم إعادته وصار له up portion
+
+501
+00:34:34,640 --> 00:34:40,460
+معناه في مشاكل صحية مشاكل نفسية مشاكل آطفية عند ال
+
+502
+00:34:40,460 --> 00:34:46,770
+two couples معناه إعادة ال cycleيعني دفع و cost
+
+503
+00:34:46,770 --> 00:34:52,790
+أعلى فده أنا بتجنبها من خلال ال BGD ايضا ال BGD
+
+504
+00:34:52,790 --> 00:34:56,950
+بيعطي ضعم نفسي من ناحية إيجابية positive بشكل كبير
+
+505
+00:34:56,950 --> 00:35:02,430
+جدا مما يساعد على إكمال الحياة و إكمال عملية
+
+506
+00:35:02,430 --> 00:35:05,890
+الإنجاب بالشكل الطبيعي لما والله السيدة و ال two
+
+507
+00:35:05,890 --> 00:35:09,550
+couples بتعرف أنه الجنين اللي تم إرجاع هو الجنين
+
+508
+00:35:09,550 --> 00:35:14,040
+السليم طبعا بصير عنده نوع من أنواع الاهتمامبشكل
+
+509
+00:35:14,040 --> 00:35:19,560
+كبير جدا القلق بقل فبالتالي معدل فقدار الجنين من
+
+510
+00:35:19,560 --> 00:35:24,220
+خلال ال stress العالي بقل بشكل كبير جدا هذه فوائد
+
+511
+00:35:24,220 --> 00:35:29,060
+ال BGD خلصنا من فوائد ال BGD واتكلمنا عنها نيجي
+
+512
+00:35:29,060 --> 00:35:32,400
+لمرحلة تانية من مراحل ال genetic testing إلها
+
+513
+00:35:32,400 --> 00:35:35,100
+علاقة بال بي جي إلها علاقة أيضا بال sex selection
+
+514
+00:35:35,100 --> 00:35:38,520
+إلها علاقة بال embryo biopsyاسمها sex selection طب
+
+515
+00:35:38,520 --> 00:35:41,700
+شو علاقة ال embryo biopsy بال sex selection؟ لأن
+
+516
+00:35:41,700 --> 00:35:45,220
+ال sex selection هو عبارة عن فحص جيني يحتاج إلى ال
+
+517
+00:35:45,220 --> 00:35:48,840
+embryo biopsy لكي يتم لأن ال embryo biopsy هي خزعة
+
+518
+00:35:48,840 --> 00:35:52,980
+من الجنين تحتوي على مادة وراثية أقوم بفحصها من
+
+519
+00:35:52,980 --> 00:35:56,980
+خلال ال sex selection طبعا ال sex selection هو
+
+520
+00:35:56,980 --> 00:36:02,770
+مصطلح يستخدم بشكل عام as a medical termas medical
+
+521
+00:36:02,770 --> 00:36:08,110
+term إذا كان هدفه طبي ولكن أصبح استخداماته مختلفة
+
+522
+00:36:08,110 --> 00:36:12,190
+ال sex selection we can use to making selection of
+
+523
+00:36:12,190 --> 00:36:15,790
+the embryo for transfer and implantation followed
+
+524
+00:36:15,790 --> 00:36:21,490
+IVF separating sperm and selectivity transmitting
+
+525
+00:36:21,490 --> 00:36:26,890
+a pregnancy يعني sex selection بمعنى آخر هو مصطلح
+
+526
+00:36:26,890 --> 00:36:32,940
+يستخدم لاختيار جنس المولود أو عمليةتستخدم لاختيار
+
+527
+00:36:32,940 --> 00:36:36,780
+جنس المولود طبعا في الغالب هي عبارة عن عملية قطبية
+
+528
+00:36:36,780 --> 00:36:40,960
+خاصة في العوائل التي تحتوي على أمراض متعلقة
+
+529
+00:36:40,960 --> 00:36:45,860
+بالفيميل فبالتالي بيعطيني فيميل مشوهة أو فيميل
+
+530
+00:36:45,860 --> 00:36:51,640
+عندها مشاكل جينية أو فيميل defect فبالتالي مش منطق
+
+531
+00:36:51,640 --> 00:36:54,360
+اروح ارجع الأجنة اللي عندهم female او ال female
+
+532
+00:36:54,360 --> 00:36:58,200
+inferior طبعا ال six solution ممكن انا اعمله من
+
+533
+00:36:58,200 --> 00:37:02,220
+خلالتحديد جينات معينة إنها علاقة بالـ Male أو بالـ
+
+534
+00:37:02,220 --> 00:37:04,720
+Female، أي طريقة أو أعمل separation للـ
+
+535
+00:37:04,720 --> 00:37:08,380
+spermatozoa إن أحضن الـ boy ده فقط بـ sperm يحمل Y
+
+536
+00:37:08,380 --> 00:37:12,460
+كروموزوم أو يحمل X كروموزوم بناء على شو الهدف من
+
+537
+00:37:12,460 --> 00:37:15,740
+ال sex selection أو بعمل حاجة بنسميها للأسف
+
+538
+00:37:15,740 --> 00:37:19,920
+بيسخدموها بشكل أو بآخر إنه selectivity pregnancy
+
+539
+00:37:19,920 --> 00:37:24,100
+أو بمعنى آخر cancelling pregnancy يعني بعد الشهر
+
+540
+00:37:24,100 --> 00:37:29,160
+التاني أو التالت أو الرابع اتأكد إنه المولودmale
+
+541
+00:37:29,160 --> 00:37:33,960
+فأجهضه اتأكد ان المولود female فأجهضها هذه تعتبر
+
+542
+00:37:33,960 --> 00:37:37,240
+طريقة من طرق ال sex selection التي كانت تستخدم
+
+543
+00:37:37,240 --> 00:37:42,580
+فيما سبق بكميات كبيرة جدا طبعا بالنسبة لل sex
+
+544
+00:37:42,580 --> 00:37:47,020
+selection has a wide range of ethical legal social
+
+545
+00:37:47,020 --> 00:37:51,440
+problem يعني ماذا ده حتى لأنه رغم انه عمر طبي الا
+
+546
+00:37:51,440 --> 00:37:55,350
+انه في بعض المشاكلالأخلاقية عليه، بعض المشاكل
+
+547
+00:37:55,350 --> 00:37:58,270
+الطبية عليه، بعض المشاكل اجتماعية عليه في بعض
+
+548
+00:37:58,270 --> 00:38:03,890
+المجتمعات ما بتقبل ان يحصل sex selection في دولتها
+
+549
+00:38:03,890 --> 00:38:07,490
+أو في مجتمعها في بعض الدول عليها فرض انه ما تعمل
+
+550
+00:38:07,490 --> 00:38:10,930
+sex selection بعد الحرب العالمية تانية تتانية انه
+
+551
+00:38:10,930 --> 00:38:14,770
+ممنوع انت كدولة تعملي genetic implantation ممنوع
+
+552
+00:38:14,770 --> 00:38:19,950
+كدولة تعملي sex selection إليها هذا من أحد الفروضة
+
+553
+00:38:19,950 --> 00:38:24,700
+اللتي فرضت عليهاطبعا الـ Gender Selection is used
+
+554
+00:38:24,700 --> 00:38:28,500
+to prevent genetic disease the process is called
+
+555
+00:38:28,500 --> 00:38:31,880
+medical genetic أو gender selection إذا كان الهدف
+
+556
+00:38:31,880 --> 00:38:36,800
+الأساسي من اختيار جنس مولود تجنب مرض ورث معين فعند
+
+557
+00:38:36,800 --> 00:38:40,940
+الإذن بسميه medical gender selection أو medical
+
+558
+00:38:40,940 --> 00:38:45,380
+sex selection وهذا الهدف الأساسي من هذه العملية من
+
+559
+00:38:45,380 --> 00:38:48,520
+أشهر الأمراض هي الأمراض المتعلقة بال sex link
+
+560
+00:38:48,520 --> 00:38:53,860
+disorder أو ال X linkdisorder التي تخصيب الذكور عن
+
+561
+00:38:53,860 --> 00:38:58,340
+الاناث بكمية كبيرة جدا بعض الأحيان يكون الهدف من
+
+562
+00:38:58,340 --> 00:39:01,300
+ال sex selection ليس طبي فبسميه في هذه الحالة
+
+563
+00:39:01,300 --> 00:39:05,540
+elective اختياري انه انا والله بدي موليد بدي عيلة
+
+564
+00:39:05,540 --> 00:39:08,600
+تكونها اناث او بدي عيلة تكونها ذكور او بدي balance
+
+565
+00:39:08,600 --> 00:39:12,220
+اتنين الاناس اتنين الذكور فادم يسميه elective sex
+
+566
+00:39:12,220 --> 00:39:17,460
+selection او non medical sex selection ايضا زي ما
+
+567
+00:39:17,460 --> 00:39:22,340
+حكينا انه اكثرالأسباب التي تؤدي لعمل sex relation
+
+568
+00:39:22,340 --> 00:39:26,240
+هي ال family balancing أنه أنا بدي عيلة فقط قفلين
+
+569
+00:39:26,240 --> 00:39:31,000
+ولد و بنت بدي عيلة خمسة ولدين و تلت بنات و تلت
+
+570
+00:39:31,000 --> 00:39:33,740
+بنات وولدين وها كذا يعني بدي نوع من أنواع
+
+571
+00:39:33,740 --> 00:39:38,940
+الإختيارية أو نوع من أنواع الإتزال في أفراد الأسرة
+
+572
+00:39:38,940 --> 00:39:43,320
+طبعا هذا الأمر منطقيا غير مقبولطب كيف بدنا نعمل
+
+573
+00:39:43,320 --> 00:39:45,300
+six selection؟ و إيش طبيعة العين اللى بدنا
+
+574
+00:39:45,300 --> 00:39:48,460
+نستخدمها؟ في مسابق كانوا يستخدموا حاجة بتسميها
+
+575
+00:39:48,460 --> 00:39:51,620
+chronic villus sampling شو يعني chronic villus
+
+576
+00:39:51,620 --> 00:39:56,780
+sampling؟ CVS chronic villus sampling ببساطة جدا
+
+577
+00:39:56,780 --> 00:40:00,700
+is a paternal test in which sample of chronic
+
+578
+00:40:00,700 --> 00:40:04,260
+villi is removed from the placenta of testing يعني
+
+579
+00:40:04,260 --> 00:40:10,090
+أنا كطبيب بروح باخد جزء أو .. يا إماخلايا من خلايا
+
+580
+00:40:10,090 --> 00:40:14,530
+البلاسينتا أو دم من دم لبلاسينتا وبعمله عملية
+
+581
+00:40:14,530 --> 00:40:18,850
+فحوصات لتبحث عن الجينات المتعلقة بال female أو
+
+582
+00:40:18,850 --> 00:40:22,730
+الجينات المتعلقة بال male بشكل أساسي that test can
+
+583
+00:40:22,730 --> 00:40:27,390
+be done as early as 10 weeks of pregnancy يعني هذا
+
+584
+00:40:27,390 --> 00:40:31,130
+الفحص أو هذا ال sample اللي سميتها chronic villus
+
+585
+00:40:31,130 --> 00:40:35,830
+sampling بتخضع لها المرأة في أول عشر أسابيع من
+
+586
+00:40:35,830 --> 00:40:39,990
+عملية الحببطبعا chronic villasamling كان exhibited
+
+587
+00:40:39,990 --> 00:40:42,970
+if a baby has chromosomal conditions such as down
+
+588
+00:40:42,970 --> 00:40:46,230
+syndrome and other type of genetic disorder like
+
+589
+00:40:46,230 --> 00:40:49,810
+cystic fibrosis also chronic villasamling can
+
+590
+00:40:49,810 --> 00:40:54,270
+provide viable information about your baby healthy
+
+591
+00:40:54,270 --> 00:40:58,590
+يعني أنا لما أخد عين الدم أو عين نسيجية من ال
+
+592
+00:40:58,590 --> 00:41:02,230
+placenta تحت مصطلح ال chronic villasamling أنا
+
+593
+00:41:02,230 --> 00:41:06,890
+باخد معلومات طبية عن حالة المولودممكن أشخص جنس
+
+594
+00:41:06,890 --> 00:41:10,570
+المولود منها ممكن أعرف هل المولود يحتوي على بعض
+
+595
+00:41:10,570 --> 00:41:13,470
+الأمراض الوراثية الـGastric Fibrosis for example
+
+596
+00:41:13,470 --> 00:41:18,170
+أو الـ Down Syndrome النوع التاني من أنواع الـ
+
+597
+00:41:18,170 --> 00:41:20,930
+material التي يمكن أن تُستخدم في حالة الـ sex
+
+598
+00:41:20,930 --> 00:41:25,470
+selection الأمنو- الامنوسينتيسيز وهي عبارة عن أخذ
+
+599
+00:41:25,470 --> 00:41:29,190
+عينة من السائل المحيط بالجنين السائل المحيط
+
+600
+00:41:29,190 --> 00:41:33,810
+بالجنين هو عبارة عن سائل مغذر الجنين، حامل الجنين
+
+601
+00:41:33,990 --> 00:41:37,390
+يحتوي على بعض الخلايا المتعلقة بالجنين فلو أنا
+
+602
+00:41:37,390 --> 00:41:41,930
+أخدت sample منها أنا كده أخدت cells related with
+
+603
+00:41:41,930 --> 00:41:45,690
+embryo يعني أنا كده أخدت مادة ورثية لها علاقة
+
+604
+00:41:45,690 --> 00:41:50,090
+بالجنين لها علاقة بالجنين what is the purpose of
+
+605
+00:41:50,090 --> 00:41:52,830
+the aminothensis? check the inherited blood
+
+606
+00:41:52,830 --> 00:41:54,870
+disorder like sickle cell anemia, hemophilia,
+
+607
+00:41:54,950 --> 00:41:59,210
+thalassemia muscular skeletal disorder check
+
+608
+00:41:59,210 --> 00:42:02,350
+chromosome abnormality and fetal infection and
+
+609
+00:42:02,350 --> 00:42:06,580
+also we can use itfor sex selection or sex
+
+610
+00:42:06,580 --> 00:42:10,820
+determination هذه أهم الصفات أو أهم الاستخدامات
+
+611
+00:42:10,820 --> 00:42:18,100
+التي تنطوي أو تتعلق باخذ عينة من السائل الجنين
+
+612
+00:42:18,100 --> 00:42:21,360
+خلينا نشوف الفيديو اللي بتكلم عن هذا الموضوع وكيف
+
+613
+00:42:21,360 --> 00:42:25,420
+بياخد العينة المتعلقة بالسائل الجنين
+
+614
+00:42:29,970 --> 00:42:33,750
+Amniocentesis Amniocentesis is a medical procedure
+
+615
+00:42:33,750 --> 00:42:37,810
+called in prenatal diagnosis of chromosomal
+
+616
+00:42:37,810 --> 00:42:43,560
+abnormalities and fetal infectionsوهي أيضًا
+
+617
+00:42:43,560 --> 00:42:46,220
+استخدامة لتحريك الزبدة في الواقع التي تحتوي عدد
+
+618
+00:42:46,220 --> 00:42:49,620
+صغير من الموارد الأمنياطية التي تحتوي على دماغ
+
+619
+00:42:49,620 --> 00:42:54,340
+أمنياطية مجموعة أمنياطية مجموعة أمنياطية مجموعة
+
+620
+00:42:54,340 --> 00:42:54,580
+أمنياطية مجموعة أمنياطية مجموعة أمنياطية مجموعة
+
+621
+00:42:54,580 --> 00:42:55,180
+أمنياطية مجموعة أمنياطية مجموعة أمنياطية مجموعة
+
+622
+00:42:55,180 --> 00:42:58,940
+أمنياطية مجموعة أمنياطية مجموعة أمنياطية مجموعة
+
+623
+00:42:58,940 --> 00:43:05,000
+أمنياطية مجموعة أمنياطية مجموعة أمنياطية مجموعة
+
+624
+00:43:05,000 --> 00:43:11,480
+أمنياطية مجموعة أمنياطية مجمو
+
+625
+00:43:39,160 --> 00:43:42,660
+ببساطة، حكى عن الـ Amniotic Fluid والسائل المحيط
+
+626
+00:43:42,660 --> 00:43:45,830
+بالجنينوسائل يحتوي على العديد من البروتينات
+
+627
+00:43:45,830 --> 00:43:48,930
+والإنزيمات المتعلقة بالجنين بالإضافة إلى بعض
+
+628
+00:43:48,930 --> 00:43:52,590
+الخلايا الجدية المتعلقة بالجنين التي يمكن فصلها
+
+629
+00:43:52,590 --> 00:43:56,430
+وعمل culture لها لكي نحصل علامات دوراتية كافية
+
+630
+00:43:56,430 --> 00:44:01,170
+لإجراء الفحوصات الطبية والفحوصات الجينية المطلوبة
+
+631
+00:44:01,170 --> 00:44:06,090
+هذا بالنسبة للـ Amnotic Fluid أو عملية الـ
+
+632
+00:44:06,090 --> 00:44:12,720
+Amnothynthesisالتي يمكن من خلالها سحب جزء من الـ
+
+633
+00:44:12,720 --> 00:44:16,480
+Amniotic Fluid لإجراء الحصافة الطبية المطلوبة
+
+634
+00:44:16,480 --> 00:44:19,800
+النوع التالت أو الطريقة التالتة من طرق عمل Sex
+
+635
+00:44:19,800 --> 00:44:22,880
+Selection وهي الـ Sperm Separation by
+
+636
+00:44:22,880 --> 00:44:27,500
+Fluocytometer أنه أنا قبل ما أعمل حقن مجهري بفصل
+
+637
+00:44:27,500 --> 00:44:31,820
+الـ spermatozoa إلى sperm تحمل Y-chromosome و
+
+638
+00:44:31,820 --> 00:44:36,380
+sperm يحمل X-chromosome وبناء على حاجة المريض بحقن
+
+639
+00:44:36,380 --> 00:44:40,800
+يا إما بالـ X-chromosomeSperm with X Chromosome أو
+
+640
+00:44:40,800 --> 00:44:44,740
+Sperm with Y Chromosome طب كيف انا بدي افصل ال X
+
+641
+00:44:44,740 --> 00:44:49,160
+عن ال Y Chromosome الموجودة في Sperm Metazoa ممكن
+
+642
+00:44:49,160 --> 00:44:54,140
+افصلها بناء على كثافة ال DNA او كمية ال DNA فوجدوا
+
+643
+00:44:54,140 --> 00:44:58,380
+ان ال Sperm Metazoa المحملة بال X Chromosome حوالي
+
+644
+00:44:58,380 --> 00:45:04,240
+2.8% more DNA than those carrying Y Chromosome
+
+645
+00:45:04,240 --> 00:45:07,700
+يعني بمعنى اخر ال Sperm Metazoaاللي إلها علاقة
+
+646
+00:45:07,700 --> 00:45:10,860
+بالـ X كرموزوم أو محمول عليها الـ X كرموزوم كمية
+
+647
+00:45:10,860 --> 00:45:13,960
+الـ DNA أكتر من الـ sperm المتزول عليها Y كرموزوم
+
+648
+00:45:13,960 --> 00:45:17,440
+بمعدل 2.8 والسبب زي أحنا ما بنعرف في الـ
+
+649
+00:45:17,440 --> 00:45:22,200
+karyotyping أن الـ Y كرموزوم أقصر من الـ X كرموزوم
+
+650
+00:45:22,200 --> 00:45:26,700
+الـ X كرموزوم very long مقارنة بالـ Y كرموزوم
+
+651
+00:45:26,700 --> 00:45:30,460
+فبالتالي وجدوا أن كمية الـ DNA في الـ X أكتر من
+
+652
+00:45:30,460 --> 00:45:34,160
+كمية الـ DNA في الـ Y أو الـ sperm المحمل عليه الـ
+
+653
+00:45:34,160 --> 00:45:41,360
+Y كرموزوم بمعدل2.8 فممكن ببساطة جدا باستخدام ال
+
+654
+00:45:41,360 --> 00:45:45,500
+fluorocytometer أستخدم صبغة هذه الصبغة related
+
+655
+00:45:45,500 --> 00:45:49,720
+with amount of DNA فهي ترتبط بكمية ال DNA الموجودة
+
+656
+00:45:49,720 --> 00:45:53,580
+هنا وكمية ال DNA الموجودة هنا طالما ال X sperm
+
+657
+00:45:53,580 --> 00:45:57,660
+يحتوي على كمية DNA أكبر فبالتالي كمية صبغة أكبر
+
+658
+00:45:57,660 --> 00:46:01,360
+هترتبط فيها طالما ال Y sperm يحتوي على كمية DNA
+
+659
+00:46:01,360 --> 00:46:08,460
+أقل هترتبط في كميةدى يعني صبغة أقل فبيجي بعد كده
+
+660
+00:46:08,460 --> 00:46:15,140
+بيجي بقطع بعمل عملية ادخال لل Siemens sample في
+
+661
+00:46:15,140 --> 00:46:18,680
+capillary tube هذه ال capillary tube تمشي من خلال
+
+662
+00:46:18,680 --> 00:46:24,120
+مثلا طيار الكهربائي و في أخرها laser line بقطع ال
+
+663
+00:46:24,120 --> 00:46:27,400
+spermatozoa و بيقيز جداش كمية الصبغة و بين أعلى
+
+664
+00:46:27,400 --> 00:46:31,760
+قيمة الصبغة مقارنة مع reference value موجودةبقسم
+
+665
+00:46:31,760 --> 00:46:36,500
+هذا X-Sperm وهذا Y-Sperm وبفصلهم إلى two separated
+
+666
+00:46:36,500 --> 00:46:40,680
+tubes بعد كده أنا واجه ما بدي أو زي ما بدي أو بناء
+
+667
+00:46:40,680 --> 00:46:43,400
+على احتياج المريض يا اما بحتنها بال spermatozoa
+
+668
+00:46:43,400 --> 00:46:46,620
+الموجودة في ال tube اللي تتحتوي على X-Sperm أو ال
+
+669
+00:46:46,620 --> 00:46:49,600
+spermatozoa الموجودة في ال tube اللي تحتوي على Y
+
+670
+00:46:49,600 --> 00:46:54,800
+-Sperm فهذه بنسميها sperm separation by flow
+
+671
+00:46:54,800 --> 00:46:58,640
+cytometer وهي عبارة عن عملية تحدث قبل عملية ال
+
+672
+00:46:58,640 --> 00:47:01,820
+fertilization قبل عملية ال fertilizationفي طريقة
+
+673
+00:47:01,820 --> 00:47:05,960
+تانية و طريقة ماشي طريقة ولكن مشكلة في كتير لغة
+
+674
+00:47:05,960 --> 00:47:10,340
+حواليها اسمها طريقة .. طريقة اسمها Ericsson
+
+675
+00:47:10,340 --> 00:47:13,180
+albumin method طبعا اللغة اللي صار حواليها لأن
+
+676
+00:47:13,180 --> 00:47:16,460
+معظم المقالات اللي نشرت كان Ericsson موجود فيها
+
+677
+00:47:16,460 --> 00:47:20,860
+يعني معظم المقالات اللي لها علاقة بفصل spermatozoa
+
+678
+00:47:20,860 --> 00:47:24,340
+بناء على طريقة Ericsson albumin method كان
+
+679
+00:47:24,340 --> 00:47:30,480
+Ericsson هو الكاتب و المؤلف الموجود في كل المقالات
+
+680
+00:47:31,050 --> 00:47:34,150
+طبعا الـ effectiveness of this method is high
+
+681
+00:47:34,150 --> 00:47:40,070
+..highly disputed يعني في عندها شكوك حواليها، في
+
+682
+00:47:40,070 --> 00:47:43,390
+لغب حواليها، في كلام عنها الريكسون method involve
+
+683
+00:47:43,390 --> 00:47:46,590
+placing special washing sperm cell on the top of
+
+684
+00:47:46,590 --> 00:47:49,910
+layer solution of albumin ببساطة جدا بجيب solution
+
+685
+00:47:49,910 --> 00:47:52,910
+of albumin و بجيب عينة ال spermatozoa بعد ال
+
+686
+00:47:52,910 --> 00:47:56,810
+washing و بعد density gradient و بعد ال swamp up
+
+687
+00:47:56,810 --> 00:48:01,010
+بحملها فوق ال solution هذاطبعا معروف أن الـ
+
+688
+00:48:01,010 --> 00:48:06,350
+thickness للألبومين مختلفة عن ال thickness للمادة
+
+689
+00:48:06,350 --> 00:48:10,630
+أو ال media اللي عملت فيها washing لل spermatozoa
+
+690
+00:48:10,630 --> 00:48:13,890
+فبالتالي ال spermatozoa بتبدأ أنها تتحرك نحو
+
+691
+00:48:13,890 --> 00:48:17,890
+الأسفل بفعلة جاذبية و المعروف كل ما اتحركنا للأسفل
+
+692
+00:48:17,890 --> 00:48:20,570
+ال thickness أو ال density تبعة ال albumin
+
+693
+00:48:20,570 --> 00:48:24,470
+solution هتكون أعلى albumin is kind of a protein
+
+694
+00:48:24,470 --> 00:48:29,060
+found in the cementThe albumin is layer with
+
+695
+00:48:29,060 --> 00:48:32,160
+increased thickness with the thickness layer in
+
+696
+00:48:32,160 --> 00:48:35,780
+the bottom معناه أنه كل ما توجهنا للأسفل هيكون ال
+
+697
+00:48:35,780 --> 00:48:38,220
+thickness أو ال density خلّيني أقول ال thickness
+
+698
+00:48:38,220 --> 00:48:41,440
+زي ما موجودة في ال slide هتكون أعلى فبالتالي هلاقي
+
+699
+00:48:41,440 --> 00:48:45,320
+ال spermatozoon هتتقاوم .. هيتلاقي مقاومة كبيرة
+
+700
+00:48:45,320 --> 00:48:50,440
+جدا أثناء عملية انتقالها من السطح لل albumin
+
+701
+00:48:50,440 --> 00:48:55,040
+solution حتى أسفل اللمبوبة الفكرة أن ال Y sperm
+
+702
+00:48:55,040 --> 00:48:59,030
+cell والسوامdown and arrive to the thick layer
+
+703
+00:48:59,030 --> 00:49:02,550
+faster ليه؟ لأن كمية الـ DNA الموجودة فيه كمية
+
+704
+00:49:02,550 --> 00:49:08,710
+قليلة جدا مقارنة بالـ X-Spermatozoa for those that
+
+705
+00:49:08,710 --> 00:49:12,310
+want a baby the filtration method is called by
+
+706
+00:49:12,310 --> 00:49:17,570
+insemination or IY طالما أنا بدي baby male هحقن
+
+707
+00:49:17,570 --> 00:49:21,230
+البوايضة من الـ spermatozoa الموجودة في منطقة ال
+
+708
+00:49:21,230 --> 00:49:25,350
+thicker solution layerوالله إذا بدي على سبيل
+
+709
+00:49:25,350 --> 00:49:29,430
+المثال female as imperial بحقنها من ال spermatozoa
+
+710
+00:49:29,430 --> 00:49:34,910
+اللي موجودة في المنطقة العلوية لإنها بتكون كثافتها
+
+711
+00:49:34,910 --> 00:49:40,050
+او كثافة ال spermatozoa أعلى لإنه Y .. او لإنه X
+
+712
+00:49:40,050 --> 00:49:43,130
+spermatozoa spermatozoa يحتوى على ال X chromosome
+
+713
+00:49:43,130 --> 00:49:47,830
+اللي فيه مادة وراثية أعلى نحيثه الكميةفي بعض
+
+714
+00:49:47,830 --> 00:49:52,550
+الأحيان بيقولك لأ أنا عندي spermatozoa كتيرة بيدور
+
+715
+00:49:52,550 --> 00:49:56,330
+على جينات معينة بيدور على جينات معينة gene that
+
+716
+00:49:56,330 --> 00:50:02,010
+are exclusive of Y-chromosome خلصت من عملية sex
+
+717
+00:50:02,010 --> 00:50:06,610
+selection سواء كان pre-implantation أو بعد ال
+
+718
+00:50:06,610 --> 00:50:11,210
+pregnancy أو قبل عملية ال fertilization باستخدام
+
+719
+00:50:11,210 --> 00:50:15,740
+ال Eryxolipamine method لأ أنا عندي سارجانينأو
+
+720
+00:50:15,740 --> 00:50:18,960
+عندى أجنة فى المختبر حقنت وبدى أرجع بس الجنين اللى
+
+721
+00:50:18,960 --> 00:50:21,080
+هو عبارة عن الـ Male أو الجنين اللى عبارة عن
+
+722
+00:50:21,080 --> 00:50:24,060
+Female إذا بدى أرجع الجنين اللى عبارة عن ال Male
+
+723
+00:50:24,060 --> 00:50:28,580
+بدى أحاول باستخدام ال Fish Technique أبحث عن جينات
+
+724
+00:50:28,580 --> 00:50:32,480
+لا توجد إلا على ال Y-Chromosome فبالتالي ببحث عن
+
+725
+00:50:32,480 --> 00:50:36,460
+جينات مهمة وهي اللى باللون الأزرق زى ال AZF
+
+726
+00:50:36,460 --> 00:50:40,400
+Azospermia Factor 1 في عند ال 6th determining
+
+727
+00:50:40,400 --> 00:50:45,280
+region Yوهي المسؤولة عن إنتاج الـ Phenotype الخاصة
+
+728
+00:50:45,280 --> 00:50:50,220
+بالميل في عند الـ TspY Testis Specific Protein Y
+
+729
+00:50:50,220 --> 00:50:55,500
+-Link في عندي كمان Basic Protein on Y-Chromosome
+
+730
+00:50:55,500 --> 00:51:02,040
+في عندي الـ Delete in Azospermia 1 وفي عند ال Y
+
+731
+00:51:02,040 --> 00:51:07,860
+-Link Protein Kinase هذه معظمها الجينات لا تتواجد
+
+732
+00:51:07,860 --> 00:51:11,200
+إلا على الـ Y-Chromosome ولكن أشهرها التلاتة اللي
+
+733
+00:51:11,200 --> 00:51:16,150
+باللونالأزرق و بالذات رقم 2 باللون الأزرق اللي
+
+734
+00:51:16,150 --> 00:51:23,410
+سمته SRY 6-Determining Region Y هذه أشهر أنواع
+
+735
+00:51:23,410 --> 00:51:26,710
+الجينات المحملة على Y كرموزوم و التي من خلالها
+
+736
+00:51:26,710 --> 00:51:32,150
+أستطيع تحديد جنس المولود أو تحديد جنس الجنين
+
+737
+00:51:32,150 --> 00:51:37,450
+الموجود في البيتردش قبل عملية الرجعة عشان كده حكيت
+
+738
+00:51:37,450 --> 00:51:42,400
+أن ال embryo بيبسي ممكن أعملها بعد كده PCRأو fish
+
+739
+00:51:42,400 --> 00:51:45,840
+technique و هذه الطريقة طريقة تحديد الجينات يمكن
+
+740
+00:51:45,840 --> 00:51:50,420
+استخدام ال fish technique فيها بشكل سريع طبعا عند
+
+741
+00:51:50,420 --> 00:51:54,420
+slide بعد ال fish technique و عملت six
+
+742
+00:51:54,420 --> 00:51:58,020
+determination لجيت فيها اندي two spots لونها blue
+
+743
+00:51:58,020 --> 00:52:01,900
+و one spot green و one spot violet ال pam fetish
+
+744
+00:52:01,900 --> 00:52:05,520
+بتقول ايه؟ بتقول ايه هذه خلية تحتوي على خلية
+
+745
+00:52:05,520 --> 00:52:09,640
+مأخوذة من جنين يعني هذه ال plus two mirror عملنا
+
+746
+00:52:09,640 --> 00:52:13,560
+لها fish techniqueعطاني green color يعني هذا X
+
+747
+00:52:13,560 --> 00:52:19,340
+كرمزوم red color يعني Y كرمزوم وعندي blue color
+
+748
+00:52:19,340 --> 00:52:25,380
+علاقة بالكرمزوم رقم 18 كرمزوم 18 as we show normal
+
+749
+00:52:25,380 --> 00:52:29,820
+يعني عندي two copy يعني هذا الكرمزوم ماعندهش انبلو
+
+750
+00:52:29,820 --> 00:52:33,820
+دي من كرمزوم 18 ممكن أستخدم الكرمزوم 21؟ okay ممكن
+
+751
+00:52:33,820 --> 00:52:39,010
+بس بدي sequence related with كرمزوم 21فهذا بقدر
+
+752
+00:52:39,010 --> 00:52:44,750
+أقول إنه male with normal number of chromosome 18
+
+753
+00:52:44,750 --> 00:52:48,110
+يعني مافي عندي مشكلة في ال chromosome 18 لأنه two
+
+754
+00:52:48,110 --> 00:52:51,450
+copy طب ليش male لأنه في عندي ال red color و هو
+
+755
+00:52:51,450 --> 00:52:54,930
+عبارة عن ال probe موجهة ضد sequence لأ تواجد إلا
+
+756
+00:52:54,930 --> 00:52:58,930
+على ال Y-chromosome كده أنا بكون حدد الجنس المولود
+
+757
+00:52:58,930 --> 00:53:02,190
+بالإضافة إلى شخصتي المولود من حيث Down Syndrome
+
+758
+00:53:02,190 --> 00:53:05,730
+اللي له علاقة بال three copy من ال chromosome 18
+
+759
+00:53:05,730 --> 00:53:08,750
+موجودة ولا لأ؟فهذا normal لأنه عندي two copies من
+
+760
+00:53:08,750 --> 00:53:12,790
+كرموزوم 18 عندي X كرموزوم و عندي Y كرموزوم طبعا
+
+761
+00:53:12,790 --> 00:53:15,690
+هذه الطريقة بتسميها Fish technique fluorescent in
+
+762
+00:53:15,690 --> 00:53:19,650
+situ hybridization technique بهذا القدر نقوم قد
+
+763
+00:53:19,650 --> 00:53:22,690
+انتهينا من ال chapter 6 على أمل أن نلتقي في ال
+
+764
+00:53:22,690 --> 00:53:26,230
+chapter السابع و الأخير ان شاء الله في المحاضرات
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/xw35hLAZ8Hg.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/xw35hLAZ8Hg.srt
new file mode 100644
index 0000000000000000000000000000000000000000..3639ef82658774de9275f9366b379db2cba51486
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/xw35hLAZ8Hg.srt
@@ -0,0 +1,1579 @@
+1
+00:00:00,720 --> 00:00:04,440
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:04,440 --> 00:00:09,020
+المرسلين سيدنا محمد الصادق الأمين  أما بعد بداية
+
+3
+00:00:09,020 --> 00:00:13,940
+نرجو لكم و لنا السلامة في ظل هذه الظروف الصعبة 
+
+4
+00:00:13,940 --> 00:00:19,760
+التي نمر بها جميعًا ثم نكرر الترحاب بكم في هذا .. في 
+
+5
+00:00:19,760 --> 00:00:24,920
+هذا المصطلح الذي بعنوان الحقن المجهري أسبابه، طرقه
+
+6
+00:00:24,920 --> 00:00:29,000
+وأساليبه تحدثنا في المحاضرة السابقة على ال
+
+7
+00:00:29,000 --> 00:00:32,820
+infertility بشكل عام أسبابها عند ال male، أسبابها
+
+8
+00:00:32,820 --> 00:00:37,560
+عند ال female وكل سبب يندرج أسفله أكثر من سبب 
+
+9
+00:00:38,080 --> 00:00:41,420
+وقفنا في المحاضرة النهائية وفي نهاية المحاضرة
+
+10
+00:00:41,420 --> 00:00:44,780
+السابقة عند مصطلح اسمه Primary Infertility
+
+11
+00:00:44,780 --> 00:00:47,700
+وSecondary Infertility  Primary Infertility
+
+12
+00:00:47,700 --> 00:00:51,640
+وSecondary Infertility بشكل أساسي له علاقة بال
+
+13
+00:00:51,640 --> 00:00:56,080
+Female فلما أقول Primary Infertility مصطلح لا يطلق
+
+14
+00:00:56,080 --> 00:01:01,160
+إلا على سيدة لم تنجب ولم تنجب حتى الآن يعني بمعنى
+
+15
+00:01:01,160 --> 00:01:07,330
+آخر زوجة متزوجة من 7 أو 8 أو 9 سنين لم تنجب حتى
+
+16
+00:01:07,330 --> 00:01:11,390
+الآن ولم تنجب فيما سابق يعني محصلة الأطفال
+
+17
+00:01:11,390 --> 00:01:16,830
+الموجودين Zero محصلة حالات الحمل Zero محصلة 
+
+18
+00:01:16,830 --> 00:01:20,190
+الإجهاض Zero هذه بسميها Primary Infertility
+
+19
+00:01:20,190 --> 00:01:24,830
+Secondary Infertility حالة تطلق على السيدة التي 
+
+20
+00:01:24,830 --> 00:01:29,210
+أصبحت غير قادرة على الإنجاب بعد أن أنجبت قد تكون
+
+21
+00:01:29,210 --> 00:01:32,950
+أنجبت مرة أو مرتين أو ثلاثة حاليًا غير قادرة على
+
+22
+00:01:32,950 --> 00:01:36,330
+الإنجاب فبسميها secondary infertility ممكن تكون
+
+23
+00:01:36,330 --> 00:01:39,430
+تعرضت لصدمة ممكن تكون تعرضت لـ أذى نفسي طبعًا
+
+24
+00:01:39,430 --> 00:01:42,970
+ممكن تكون تعرضت لـ radiotherapy ممكن تكون تعرضت لـ
+
+25
+00:01:42,970 --> 00:01:46,490
+chemotherapy كل هذه أسباب تعتبر من العوامل أو
+
+26
+00:01:46,490 --> 00:01:51,090
+الأسباب التي تؤدي إلى ال secondary infertility أما
+
+27
+00:01:51,090 --> 00:01:55,130
+بالنسبة إلى العوامل التي قد تؤثر على العقم تحت 
+
+28
+00:01:55,130 --> 00:02:00,890
+عنوان لما أقول infertility يعني بالدرجة تحتها Male
+
+29
+00:02:00,890 --> 00:02:04,470
+and Female أول عامل من العوامل التي تؤثر على ال
+
+30
+00:02:04,470 --> 00:02:09,270
+infertility هي ال maternal age عمر السيدة طبعًا عمر
+
+31
+00:02:09,270 --> 00:02:13,790
+السيدة بناء على دراسات سابقة بشكل كبير جدا يلعب
+
+32
+00:02:13,790 --> 00:02:18,570
+دورًا أساسيًا ومهمًا في الإنجاب و الحصول على طفل سواء 
+
+33
+00:02:18,570 --> 00:02:21,870
+كان الإنجاب طبيعيًا أو الإنجاب عن طريق الحقن
+
+34
+00:02:21,870 --> 00:02:27,160
+المجهري لدرجة أن معظم الباحثين تجاهلوا ولم يهتموا
+
+35
+00:02:27,160 --> 00:02:31,800
+بعمر الأب فقالوا أن عمر السيدة وعمر الأنثى هو
+
+36
+00:02:31,800 --> 00:02:36,800
+العمر والمحدد الأساسي لدرجة نجاح عملية الحمل أو
+
+37
+00:02:36,800 --> 00:02:40,980
+درجة نجاح الحقن المجهري من جديد سبع ثمان سنين أو
+
+38
+00:02:40,980 --> 00:02:46,860
+ست سنين أصبح لعمر الأب دورًا مهمًا في عملية نجاح
+
+39
+00:02:46,860 --> 00:02:51,460
+الحقن المجهري أو نجاح عملية التلقيح الطبيعي وأصبحت
+
+40
+00:02:51,460 --> 00:02:55,880
+تتكرر الدراسات حول ال paternal age خلينا حاليًا في
+
+41
+00:02:55,880 --> 00:02:59,200
+الـ Maternal Age الـ Maternal Age عمر السيدة أو
+
+42
+00:02:59,200 --> 00:03:04,340
+عمر الأم هو العامل الأساسي الذي يؤثر على ال
+
+43
+00:03:04,340 --> 00:03:08,260
+fertility عند ال female كيف يصير؟ ببساطة جدا
+
+44
+00:03:08,260 --> 00:03:12,440
+بقول لك أن ال female تصل إلى ال maximum fertility
+
+45
+00:03:12,440 --> 00:03:15,780
+تليها في فترة زمنية معينة تبدأ ال infertility
+
+46
+00:03:15,780 --> 00:03:20,180
+عندها يصيبها decline في 24 سنة يعني بعد أن تبلغ 24 سنة 
+
+47
+00:03:20,180 --> 00:03:22,780
+يصير ال infertility والقدرة على الإنجاب تقل 
+
+48
+00:03:22,780 --> 00:03:28,520
+تدريجيًا ولكن تتسارع هذه العملية في التناقص أو ال
+
+49
+00:03:28,520 --> 00:03:32,840
+infertility تتسارع في التناقص لما تصل ل 37 إذا عند
+
+50
+00:03:32,840 --> 00:03:40,480
+24 تقل تدريجيًا تصل ل 37 تقل بشكل سريع جدا طبعًا
+
+51
+00:03:40,480 --> 00:03:44,800
+ما فيش تفسير لهذا الموضوع إلا إما يصير عندها نقص
+
+52
+00:03:44,800 --> 00:03:49,690
+في عدد البويضات أو يصير عندها dysfunctional في ال
+
+53
+00:03:49,690 --> 00:03:53,530
+ovary أو يصير عندها نقص في ال quality تبع البويضة
+
+54
+00:03:53,530 --> 00:03:56,410
+هذه الثلاث theories اللي كانت مطروحة 
+
+55
+00:03:56,410 --> 00:04:02,350
+dysfunctional في ال ovary reduction في ال egg
+
+56
+00:04:02,350 --> 00:04:05,830
+quality أو reduction في ال egg quantity هذه 
+
+57
+00:04:05,830 --> 00:04:09,430
+الثلاث فرضيات بشكل أساسي بعض الفحوصات التي
+
+58
+00:04:09,430 --> 00:04:15,630
+أجريت على ال model مثل الفئران والأغنام على سبيل 
+
+59
+00:04:15,630 --> 00:04:24,300
+المثال وجدوا أن الإناث في سن متأخر يعني 40 مثلا 39
+
+60
+00:04:24,300 --> 00:04:29,100
+.. 37 انخفض عندها عدد البويضات وكان هذا العدد من البويضات
+
+61
+00:04:29,100 --> 00:04:33,020
+يمكن تلقيحه ولكن تكون ال quality تبعتها قليلة
+
+62
+00:04:33,020 --> 00:04:39,720
+جدا فظهرت نظرية ونتيجة أن عدد البويضات أو
+
+63
+00:04:39,720 --> 00:04:45,180
+السيدات أو الإناث في عمر متأخر جدا يمكن أن تعطي
+
+64
+00:04:45,570 --> 00:04:50,030
+بويضات وهذه البويضات تكون صالحة للإخصاب والتلقيح
+
+65
+00:04:50,030 --> 00:04:54,750
+ولكن ال quality تبعتها تكون قليلة فتم وضع band
+
+66
+00:04:54,750 --> 00:04:59,690
+أساسي أن ال maternal age له علاقة بشكل أساسي في ال
+
+67
+00:04:59,690 --> 00:05:05,290
+reduction لل egg quality أو ال reduction لل oocyte
+
+68
+00:05:05,290 --> 00:05:09,510
+quality فوجدوا positive correlation ما بين زيادة 
+
+69
+00:05:09,510 --> 00:05:14,090
+عفوًا وجدوا negative correlation ما بين زيادة عمر
+
+70
+00:05:14,090 --> 00:05:20,780
+السيدة ونقصان ال quality تبع ال oocyte فكلما زاد
+
+71
+00:05:20,780 --> 00:05:24,120
+عمر
+
+72
+00:05:24,120 --> 00:05:28,140
+السيدة قلت ال oocyte quality عشان كده سموها
+
+73
+00:05:28,140 --> 00:05:33,200
+negative correlation على سبيل المثال وجدوا أن
+
+74
+00:05:33,200 --> 00:05:38,100
+الأنثى تولد في فترة تكون الجنين عندما يكون الجنين 
+
+75
+00:05:38,100 --> 00:05:45,200
+أنثى تعمل على إنتاج 7 إلى 6 مليون بويضة في الأسبوع 
+
+76
+00:05:45,200 --> 00:05:49,020
+رقم 20 من الحمل إذا كان الجنين أنثى يعني إذا كان
+
+77
+00:05:49,020 --> 00:05:53,640
+الجنين أنثى يكون يحتوي في مخزونه من 6 ل 7 مليون 
+
+78
+00:05:53,640 --> 00:05:58,720
+هذه البويضات تستمر في الانقسام لفترة زمنية معينة
+
+79
+00:05:58,720 --> 00:06:03,020
+تيجي في حاجة نسميها الـ Pro phase في الانقسام
+
+80
+00:06:03,020 --> 00:06:06,600
+المايوزي الأول هنتكلم عن مراحل انقسام المايوزي الأول
+
+81
+00:06:06,600 --> 00:06:10,060
+ومراحل انقسام المايوزي الثاني عند ال male و عند ال
+
+82
+00:06:10,060 --> 00:06:13,680
+female وإيش الفرق ما بينهم في المحاضرات اللاحقة إن 
+
+83
+00:06:13,680 --> 00:06:17,930
+شاء الله ولكن أنا أبدأ أقول وأؤسس الشغلة أن ال
+
+84
+00:06:17,930 --> 00:06:22,590
+female إذا كان الجنين الذي بداخلها أنثى الجنين
+
+85
+00:06:22,590 --> 00:06:27,530
+الأنثى في الأسبوع رقم 20 يكون يملك من 6 إلى 7
+
+86
+00:06:27,530 --> 00:06:32,030
+مليون بويضة من 6 إلى 7 مليون بويضة هذه البويضة
+
+87
+00:06:32,030 --> 00:06:36,110
+تكون على شكل Primordial Follicle بسميها في مخزون في
+
+88
+00:06:36,110 --> 00:06:39,310
+منطقة بسميها Primordial Follicle يصير لها هي
+
+89
+00:06:39,310 --> 00:06:44,330
+Arrested إيقاف في طور معين يسمى الـ Prophase
+
+90
+00:06:44,330 --> 00:06:48,770
+للميتافيزي لانقسام المايوزي الأول لأن عندي فيها انقسام
+
+91
+00:06:48,770 --> 00:06:51,590
+مايوزي أول وانقسام مايوزي ثاني هذه البويضات في مرحلة 
+
+92
+00:06:51,590 --> 00:06:56,410
+ال Primordial Follicle تجد في ال Prophase لطور
+
+93
+00:06:56,410 --> 00:07:01,750
+الخاص بانقسام المايوزي الأول بعد فترة من الزمن
+
+94
+00:07:02,330 --> 00:07:05,790
+الكمية كبيرة جدا من 6 إلى 7 مليون بويضة تذهب
+
+95
+00:07:05,790 --> 00:07:09,790
+لمرحلة نسميها atragia ال atragia يعني قتل الخلايا 
+
+96
+00:07:09,790 --> 00:07:13,590
+أو موت الخلايا زيها زي ال apoptosis إلى حد ما ولكن
+
+97
+00:07:13,590 --> 00:07:18,350
+في حالة ال Oocyte نسميها atragia فيصير reduction 
+
+98
+00:07:18,350 --> 00:07:22,410
+في عدد البويضات من 6 إلى 7 مليون إلى 2 مليون فقط
+
+99
+00:07:22,410 --> 00:07:27,810
+لغير عند .. فقط عندما تولد يعني عندما يولد الجنين 
+
+100
+00:07:27,810 --> 00:07:31,990
+الأنثى يصير .. صار عندها atragia وتناقص لعدد
+
+101
+00:07:31,990 --> 00:07:37,510
+البويضات من سبعة مليون إلى اثنين مليون من عمر يوم
+
+102
+00:07:37,510 --> 00:07:42,930
+واحد حتى سن البلوغ إن سن البلوغ تصير عند السيدة أو 
+
+103
+00:07:42,930 --> 00:07:47,090
+عند الأنثى فقط سبعمائة ألف بويضة لأن كمان صار
+
+104
+00:07:47,090 --> 00:07:50,690
+مرحلة ثانية من مراحل ال atresia وهي تناقص في عدد
+
+105
+00:07:50,690 --> 00:07:56,090
+البويضات المرحلة الثانية كانت من عمر عشرين شهر حتى 
+
+106
+00:07:56,090 --> 00:08:00,280
+الميلاد وصير فيه تناقص لعدد البويضات من 7 مليون ل
+
+107
+00:08:00,280 --> 00:08:05,240
+2 مليون المرحلة الثانية من الميلاد حتى البلوغ صار 
+
+108
+00:08:05,240 --> 00:08:10,500
+تناقص من 2 مليون ل 700 ألف بويضة يعني الأنثى
+
+109
+00:08:10,500 --> 00:08:15,780
+عندما تبلغ وتصل إلى سن الرشد تكون تملك 700 ألف
+
+110
+00:08:15,780 --> 00:08:22,760
+بويضة كل شهر تنطلق بويضتان أو ثلاث بويضات في الشهر 
+
+111
+00:08:22,760 --> 00:08:28,140
+ثلاث في 12 في .. لو قلنا على 15 سنة، 15 لحد دي
+
+112
+00:08:28,140 --> 00:08:31,760
+تلقاه ال 40 شوف كم سنة واضرب كم بويضة بيصير
+
+113
+00:08:31,760 --> 00:08:37,100
+خسارة هذه السيدة عند سن ال 37 بيصير عندها مخزون
+
+114
+00:08:37,100 --> 00:08:44,860
+يقدر ب 25 ألف بويضة فبالتالي كل ما تقدم العمر في
+
+115
+00:08:44,860 --> 00:08:49,000
+عندها reduction في ال Oocyte number من خلال 
+
+116
+00:08:49,000 --> 00:08:52,380
+التسلسل الزمني الذي رأيناه بالإضافة إلى فيه
+
+117
+00:08:52,380 --> 00:08:55,220
+reduction في ال oocyte quality من خلال التجارب
+
+118
+00:08:55,220 --> 00:09:01,060
+التي أجريت على الفئران وال animals So there is a
+
+119
+00:09:01,060 --> 00:09:04,520
+high chance that the egg released at ovulation has
+
+120
+00:09:04,520 --> 00:09:08,240
+been abnormal chromosome أقول لك كل ما زاد العمر
+
+121
+00:09:08,240 --> 00:09:11,820
+الخاص بال female كل ما زاد العمر الخاص بال female 
+
+122
+00:09:11,820 --> 00:09:16,800
+نجد ثلاث أحداث تصير زيادة في معدل ال atragia وهي
+
+123
+00:09:16,800 --> 00:09:22,530
+عبارة عن reduction في عدد البويضات زيادة في ال
+
+124
+00:09:22,530 --> 00:09:25,530
+oocyte quality .. ال oocyte quality يصير عندها
+
+125
+00:09:25,530 --> 00:09:29,110
+reduction في معدل أو في جودة ال oocyte يصير
+
+126
+00:09:29,110 --> 00:09:32,590
+عندها reduction كمان كل ما زاد العمر عند ال female
+
+127
+00:09:32,590 --> 00:09:36,750
+نلاجي نسبة ال ovulation لبويضات عندها abnormality
+
+128
+00:09:36,750 --> 00:09:39,930
+كروموزومية ال abnormality تكون عالية جدا وهذا
+
+129
+00:09:39,930 --> 00:09:43,230
+الكروموزوم ال abnormality تكون بفعل أخطاء خلال
+
+130
+00:09:43,230 --> 00:09:46,910
+انقسام المايوزي .. خلال انقسام المايوزي إذا ثلاث 
+
+131
+00:09:46,910 --> 00:09:53,320
+أسباب وثلاث أمور تحدث خلال تطور العمر وزيادة العمر
+
+132
+00:09:53,320 --> 00:09:58,100
+عند السيدة نقصان عدد البويضات نقصان جودة البويضات 
+
+133
+00:09:58,100 --> 00:10:03,140
+وزيادة فرصة ظهور بويضات تحمل chromosomal
+
+134
+00:10:03,140 --> 00:10:07,240
+abnormality بفعل ال problem التي تصير خلال انقسام
+
+135
+00:10:07,240 --> 00:10:13,540
+المايوزي طيب في أمور أخرى ممكن تؤدي وهي عبارة عن
+
+136
+00:10:13,540 --> 00:10:17,460
+ظهور ما يعرف باسم الانبلودي والانبلودي مصطلح يطلق
+
+137
+00:10:17,460 --> 00:10:21,680
+على مشكلة في عدد الكروموزومات يعني انضمام زيادة في
+
+138
+00:10:21,680 --> 00:10:25,980
+عدد الكروموزومات هذه الأسباب غير معروفة حتى الآن
+
+139
+00:10:25,980 --> 00:10:30,560
+ولكن بعضهم يرى أن الانبلويد الذي يصير في ال VYDATA 
+
+140
+00:10:30,560 --> 00:10:34,660
+عند ال Advanced Age Maternal Advanced Age أول حاجة 
+
+141
+00:10:34,660 --> 00:10:39,880
+dysfunctional في الـMitotic Spindle المسؤول عن
+
+142
+00:10:39,880 --> 00:10:45,660
+الـAnaphase ويعبر عن انقسام الكروموزومات إلى 
+
+143
+00:10:46,090 --> 00:10:50,250
+وانفصالهم إلى أقطاب الخلية في مرحلة الـanaphase
+
+144
+00:10:50,250 --> 00:10:53,050
+يصير في عندي dysfunction في هذه الـ spindle fiber
+
+145
+00:10:53,050 --> 00:10:57,710
+أو بيصير عندي مشكلة في الـ adhesion between sister
+
+146
+00:10:57,710 --> 00:11:01,250
+chromatid في حاجة اسمها التصالب والعبور أن الـ two
+
+147
+00:11:01,250 --> 00:11:04,490
+sister chromatid الداخليات بيصير في تبادل لبعض
+
+148
+00:11:04,490 --> 00:11:10,730
+القطع الـ DNA فإذا صار في عندي مشكلة في عملية فصل
+
+149
+00:11:10,730 --> 00:11:15,630
+الـ sister chromatid معناه يؤدي إلى عمل Aneuploidy
+
+150
+00:11:15,760 --> 00:11:18,940
+لأن الكروموزوم الـ 2 copy of الكروموزوم هيروح في
+
+151
+00:11:18,940 --> 00:11:23,200
+اتجاه خلية واحدة فالخلية الأخرى تكون تحتوى على عدد
+
+152
+00:11:23,200 --> 00:11:27,040
+من هذه الكروموزومات تكون تحتوى على عدد من
+
+153
+00:11:27,040 --> 00:11:29,780
+هذه الكروموزومات طبعا الكروموزوم الـ abnormality
+
+154
+00:11:29,780 --> 00:11:35,160
+تستطيع أن تفسر ما يقارب 70 إلى 80% من حالات فقدان
+
+155
+00:11:35,160 --> 00:11:38,640
+الجنين في أول تلات شهور فقدان الجنين في أول تلات
+
+156
+00:11:38,640 --> 00:11:42,840
+شهور 80% من نسبتهم يكون سببها Chromosomal
+
+157
+00:11:42,840 --> 00:11:50,180
+abnormality دراسة تم إجراءها في مصابق فينت أن 
+
+158
+00:11:50,180 --> 00:11:56,100
+الـ Aneuploidy كنسبة بتزيد مع زيادة عمر الأم فإذا كانت
+
+159
+00:11:56,100 --> 00:12:02,650
+الأم 30 سنة نسبة الـ Aneuploidy 2% 35 سنة 4% نسبة الـ Aneuploidy
+
+160
+00:12:02,650 --> 00:12:10,170
+40 سنة 5% نسبة الـ Aneuploidy 45 سنة 8% نسبة
+
+161
+00:12:10,170 --> 00:12:14,470
+الـ Aneuploidy فوجدوا أن في عندي positive correlation
+
+162
+00:12:14,470 --> 00:12:19,730
+ما بين عمر الأم ونسبة ظهور الـ Aneuploidy كل ما زاد عمر
+
+163
+00:12:19,730 --> 00:12:24,070
+الأم كل ما كانت نسبة ظهور الـ Aneuploidy في الجنين أعلى
+
+164
+00:12:24,070 --> 00:12:29,970
+بكافة أي فكرة وسببوعامل من العوامل التي تؤثر عند
+
+165
+00:12:29,970 --> 00:12:32,670
+الـ infertility  ان الـ female وهي ميارة باسم الـ
+
+166
+00:12:32,670 --> 00:12:36,330
+maternal age نيجي للشق التاني اللي كان مهمل اسمه
+
+167
+00:12:36,330 --> 00:12:40,730
+paternal age وجدوا على سبيل المثال أن الـ testosterone
+
+168
+00:12:40,730 --> 00:12:45,430
+يفرث بشكل مستمر في جسم الإنسان الذكر من أجل تحفيز
+
+169
+00:12:45,430 --> 00:12:50,410
+التستوستيرون لإنتاج الـ sperm نسبة الـ testosterone تقل
+
+170
+00:12:50,410 --> 00:12:55,830
+تدريجيا عن سن الأربعين بدراسة بسيطة على ذكور عمرهم
+
+171
+00:12:55,830 --> 00:13:02,430
+75 سنة وجدوا أن نسبة الـ testosterone عندهم تساوي نصف
+
+172
+00:13:02,430 --> 00:13:06,570
+كمية الـ testosterone في شاب عمره 20 سنة يعني لو أجبت
+
+173
+00:13:06,570 --> 00:13:11,310
+أنا 75 سنة مجموعة ذكور 75 سنة ومجموعة ذكور 20 سنة
+
+174
+00:13:11,310 --> 00:13:14,950
+هألاجي نسبة الـ testosterone كمية الـ testosterone عند
+
+175
+00:13:14,950 --> 00:13:19,070
+الذكور اللي عمرهم 75 وفوج تساوي نصف كمية
+
+176
+00:13:19,070 --> 00:13:24,550
+الـ testosterone اللي عند الذكور عمرهم الـ testosterone
+
+177
+00:13:24,550 --> 00:13:29,110
+بيلعب دور مهم في إنتاج الحيوانات المنوية تناقص
+
+178
+00:13:29,110 --> 00:13:33,590
+الـ testosterone بشكل ملحوظ يؤدي إلى reduction في الـ
+
+179
+00:13:33,590 --> 00:13:38,190
+sperm count reduction في الـ sperm morphology ولكن
+
+180
+00:13:38,190 --> 00:13:42,310
+لا يؤدي إلى انعدام لا يؤدي إلى انعدام فالـ semen
+
+181
+00:13:42,310 --> 00:13:46,090
+parameter وجدوا .. وجدت بعض الدراسات أن semen
+
+182
+00:13:46,090 --> 00:13:50,510
+parameter التي قد تتأثر بعمر الذكور هي عبارة عن
+
+183
+00:13:50,510 --> 00:13:54,230
+الـ Semen Volume الـ Motility الـ Semen Morphology الـ
+
+184
+00:13:54,230 --> 00:13:57,310
+Normal Morphology وبعضهم قال الـ Sperm Count أو
+
+185
+00:13:57,310 --> 00:14:01,030
+الـ Sperm Concentration فبالدراسات قالت إن والله
+
+186
+00:14:01,030 --> 00:14:05,210
+الـ Age يؤثر تأثيرا سلبيا على الـ Semen Parameters
+
+187
+00:14:05,210 --> 00:14:09,010
+زيادة الـ Age بيؤدي لنقصان الـ Volume ونقصان الـ
+
+188
+00:14:09,010 --> 00:14:11,750
+Sperm Quality ونقصان الـ Sperm Concentration
+
+189
+00:14:11,750 --> 00:14:14,790
+ونقصان الـ Sperm Motility بعض الدراسات خلفت
+
+190
+00:14:14,790 --> 00:14:19,300
+الموضوع دو قالت لأالـ paternal age لا يؤثر سلبيا
+
+191
+00:14:19,300 --> 00:14:22,860
+على الـ semen parameter إذا there is no
+
+192
+00:14:22,860 --> 00:14:27,200
+significant relationship between paternal age and
+
+193
+00:14:27,200 --> 00:14:31,200
+semen parameter هذه دراسة قالت كده ودراسة قالت كده
+
+194
+00:14:31,200 --> 00:14:35,500
+ودراسات قالت بنفس الشكل ودراسات عاكسات ما تم توصيه
+
+195
+00:14:35,500 --> 00:14:40,160
+الـ Aneuploidy أيضا وجدوا أنه يعتبر عامل أساسي
+
+196
+00:14:40,160 --> 00:14:44,070
+ومهم عند الذكورو يؤثر على الـ fertility سواء كان
+
+197
+00:14:44,070 --> 00:14:47,630
+الـ Aneuploidy او ما يُعرف باسم الـ disomy بصلاحة
+
+198
+00:14:47,630 --> 00:14:54,670
+Disomy ببساطة جدا أنه استقبال two copy of كروموزوم
+
+199
+00:14:54,670 --> 00:14:59,650
+from the same parent يعني أنا حصلت على كروموزوم رقم
+
+200
+00:14:59,650 --> 00:15:03,510
+11 من الأم كروموزوم رقم 11 اللي جاي من الأب مش
+
+201
+00:15:03,510 --> 00:15:08,610
+موجود فده بسمي الحالة Disomy Disomy ببساطة هي
+
+202
+00:15:08,610 --> 00:15:15,270
+حالة تطلق على شخص أو Embryo الإمبريو حصل على كلا
+
+203
+00:15:15,270 --> 00:15:19,290
+النسختين من الكروموزوم معين من مصدر واحد، يا إما
+
+204
+00:15:19,290 --> 00:15:23,830
+كلاهما من الأب أو كلاهما من الأم فوجدوا أن
+
+205
+00:15:23,830 --> 00:15:27,450
+الـ Aneuploidy أو الـ Disomy إذا حدثت في الـ Spermatozoa
+
+206
+00:15:27,450 --> 00:15:32,490
+تؤدي إلى فقدان الحمل، لما يقول Pregnancy lose يعني
+
+207
+00:15:32,490 --> 00:15:37,590
+فقدانه في أول تلت شهور من عملية الحمل معدل
+
+208
+00:15:37,590 --> 00:15:41,690
+الـ Aneuploidy في الـ Sperm فقط 2% معدل الـ Aneuploidy في
+
+209
+00:15:41,690 --> 00:15:47,350
+الـ Sperm 2% and there is no evidence to support
+
+210
+00:15:47,350 --> 00:15:51,270
+an increased rate of aneuploidy involving autosomal
+
+211
+00:15:51,270 --> 00:15:55,930
+in males with advanced age يعني بس فقط معدل
+
+212
+00:15:55,930 --> 00:16:00,670
+الـ Aneuploidy حدوثه عند الذكور 2% حتى الآن دراسات
+
+213
+00:16:00,670 --> 00:16:05,450
+قليلة جدا ولا تكاد تذكر اللي دعمت هذه الفرضية أو
+
+214
+00:16:05,450 --> 00:16:12,530
+قالت إن الـ Aneuploidy يزيد بزيادة عمر الذكر شو السبب؟
+
+215
+00:16:12,530 --> 00:16:18,590
+بمنطق جدا إن الحيوانات المنوية في حالة تخليق وتكوين
+
+216
+00:16:18,590 --> 00:16:23,990
+وإنشاء بشكل مستمر لا تخلق وتخزن لفترة زمنية طويلة
+
+217
+00:16:23,990 --> 00:16:28,790
+جدا لكي يحدث فيها abnormal خلال القسم الميوزي وإن
+
+218
+00:16:28,790 --> 00:16:34,190
+حدث بيصير لها reprogramming بشكل مستمر أو
+
+219
+00:16:34,190 --> 00:16:39,030
+repairing بخلاف الـ Oocyte الـ time of intercourse
+
+220
+00:16:39,030 --> 00:16:43,590
+وقت الاتصال أو وقت الاتصال بين الـ male و الـ female
+
+221
+00:16:43,590 --> 00:16:48,190
+يعتبر من أهم الأسباب أو العوامل التي تؤثر على الـ
+
+222
+00:16:48,190 --> 00:16:52,070
+fertility فكل ما كان وقت الـ intercourse بين الـ
+
+223
+00:16:52,070 --> 00:16:56,150
+male و الـ female الزوج و الزوجة قريب من وقت الطبيعي
+
+224
+00:16:56,150 --> 00:17:00,730
+كل ما كانت فرصة الـ fertilization أعلى كل ما كانت الـ
+
+225
+00:17:00,730 --> 00:17:03,570
+infertility أقل كل ما كانت فرصة الحصول على
+
+226
+00:17:03,570 --> 00:17:07,810
+pregnancy أعلى بكثير طب شو هو الأيام هذه؟ 12 .. 13
+
+227
+00:17:07,810 --> 00:17:11,650
+.. 14 طبعا تختلف باختلاف الـ Menstrual cycle
+
+228
+00:17:11,650 --> 00:17:17,870
+duration حنتكلم فيها الـ Biohazard بعض المجتمعات في
+
+229
+00:17:17,870 --> 00:17:21,590
+عندها Biohazard بتأثر على الـ infertility بشكل كبير
+
+230
+00:17:21,590 --> 00:17:26,860
+خصوصا الناس اللي بتشتغل فيها المزارعين الناس تشتغل في
+
+231
+00:17:26,860 --> 00:17:29,860
+الزراعة الناس تشتغل في مصانع المبيدات الحشرية
+
+232
+00:17:29,860 --> 00:17:34,220
+تشتغل في مصانع البطاريات تشتغل في مصانع الاسفنج في
+
+233
+00:17:34,220 --> 00:17:38,660
+بعض الـ Biohazard اللي بتعرضولهم فمن أشهر الـ Hazard
+
+234
+00:17:38,660 --> 00:17:42,200
+اللي بتعرضهم بعيد عن الـ Biohazard من أشهرها الـ
+
+235
+00:17:42,200 --> 00:17:45,620
+Nitrous Oxide الـ Nitrous Oxide وجدوا أنه له علاقة
+
+236
+00:17:45,620 --> 00:17:49,280
+بالـ Spontaneous Abortion بالإضافة إلى أنه يرتبط
+
+237
+00:17:49,280 --> 00:17:53,800
+ارتباطا وثيقا باختزال وتناقص الـ fertility عند الـ Male
+
+238
+00:17:53,800 --> 00:17:58,340
+وعند الـ Female إضافة إلى بعض المواد الكيميائية
+
+239
+00:17:58,340 --> 00:18:02,120
+اللي ممكن نتعرض لها زي المواد الكيميائية الموجودة
+
+240
+00:18:02,120 --> 00:18:06,860
+في السجائر النيكوتين والكاديوم المواد الموجودة في
+
+241
+00:18:06,860 --> 00:18:12,460
+البطاريات هذه كلها مواد كيميائية ثقيلة سامة تؤثر
+
+242
+00:18:12,460 --> 00:18:17,380
+على الـ infertility بشكل تراكمي .. بشكل تراكمي عند
+
+243
+00:18:17,380 --> 00:18:21,940
+الـ Male و عند الـ Female نجي لعمل تاني وهو الغذاء
+
+244
+00:18:21,940 --> 00:18:26,060
+طبعا عملية الـ Oogenesis تخلق البويضات
+
+245
+00:18:26,060 --> 00:18:30,880
+وعملية الـ Spermatogenesis تخلق النطف عند الرجال هي
+
+246
+00:18:30,880 --> 00:18:35,080
+عملية تحتاج إلى مواد غذائية معينة ومركبات معينة زي
+
+247
+00:18:35,080 --> 00:18:38,800
+الفركتوز مثال لـ Spermatozoa عشان تتحرك بتحتاج إلى
+
+248
+00:18:38,800 --> 00:18:42,620
+Fructose فهي ممكن يكون عندك كل الأمور طبيعية ما عدا
+
+249
+00:18:42,620 --> 00:18:46,980
+الحركة عندك Abnormal، بذكر بتحتاج إلى مواد غذائية
+
+250
+00:18:46,980 --> 00:18:50,760
+تحتوي على الـ Fructose فبتؤدي إلى تنشيط الـ Sperm
+
+251
+00:18:50,760 --> 00:18:54,510
+ويمكنه يؤدي إلى تحسين الباراميترات تبع الـ Sperm
+
+252
+00:18:54,510 --> 00:18:57,310
+Motility أو الـ Progressive Sperm Motility الـ
+
+253
+00:18:57,310 --> 00:19:00,490
+Progressive Sperm Motility مصطلح يطلق على الـ
+
+254
+00:19:00,490 --> 00:19:04,870
+Spermatozoa التي تتحرك بشكل نشط One Way One
+
+255
+00:19:04,870 --> 00:19:10,250
+Direction فبالتالي الغذاء بيلعب دور كبير جدا كمواد
+
+256
+00:19:10,250 --> 00:19:15,430
+غذائية أيضا الغذاء إن كان صحي أو غير صحي ولو أنا
+
+257
+00:19:15,430 --> 00:19:19,170
+بدي أفسر الغذاء أكتر بدي أعمل دراسة على الـ Body
+
+258
+00:19:19,170 --> 00:19:24,390
+Mass Index الـ Body Mass Index يعني في عندي Obese
+
+259
+00:19:24,390 --> 00:19:27,710
+ولا ما فيش عنده Obese؟ فوجدوا بعض الدراسات وجدت أن
+
+260
+00:19:27,710 --> 00:19:33,410
+الـ Women with Body Mass Index أقل من 19 أو Body
+
+261
+00:19:33,410 --> 00:19:39,670
+Fat حوالي أقل من 22% هم عبارة عن Risk
+
+262
+00:19:39,670 --> 00:19:44,290
+للـ Hypothalamic Dysfunction اللي بيأثر على الـ
+
+263
+00:19:44,290 --> 00:19:49,190
+Ovulation يعني أي سيدة عندها كمية الـ Fat في جسمها
+
+264
+00:19:49,190 --> 00:19:54,100
+أقل من 22% أو الـ Body Mass Index الخاص فيها أقل من
+
+265
+00:19:54,100 --> 00:19:59,060
+19 معناها بتكون عرضة إلى خلل في الـ Hypothalamus
+
+266
+00:19:59,060 --> 00:20:04,380
+يسمى Hypothalamic Dysfunction هذا الخلل يؤثر على
+
+267
+00:20:04,380 --> 00:20:10,040
+الـ Ovulation من خلال عمل Abnormality في الـ FSH و
+
+268
+00:20:10,040 --> 00:20:16,000
+الـ LH Production at the other hand بعض السيدات
+
+269
+00:20:16,000 --> 00:20:19,230
+اللي عندهم زيادة في الـ Body Mass Index يكون لهم
+
+270
+00:20:19,230 --> 00:20:25,110
+عرضة للإصابة بالـ PCOS اللي سميتها Polycystic
+
+271
+00:20:25,110 --> 00:20:28,150
+Ovarian Syndrome اللي هي عبارة عن الـ Follicle
+
+272
+00:20:28,150 --> 00:20:32,510
+بتكون وصلت لمرحلة النضوج الـ Diameter تبعتها 18
+
+273
+00:20:32,510 --> 00:20:36,410
+يعني مرحلة النضوج ولكن فارغة من الداخل طبعا هذا
+
+274
+00:20:36,410 --> 00:20:42,540
+الـ PCOS يكون يؤدي إلى طبعا سبب من أسبابه أو أحد
+
+275
+00:20:42,540 --> 00:20:46,140
+العلاقات التي تؤدي إليه هي عبارة عن الـ High Body
+
+276
+00:20:46,140 --> 00:20:49,520
+Mass Index أو Increasing Body Mass Index فده طبعا
+
+277
+00:20:49,520 --> 00:20:53,020
+بيؤدي إلى Ovulation Problem أو Ovulation
+
+278
+00:20:53,020 --> 00:20:56,440
+Dysfunction there is growing evidence that
+
+279
+00:20:56,440 --> 00:20:59,020
+increased body weight itself may be reduce
+
+280
+00:20:59,020 --> 00:21:03,140
+fertility aside from its impact on ovulatory
+
+281
+00:21:03,140 --> 00:21:08,060
+function لذن لمعنى آخر الغذاء من حيث المكونات
+
+282
+00:21:08,060 --> 00:21:12,300
+الغذائية المتواجدة فيه تؤثر على الovulation تؤثر
+
+283
+00:21:12,300 --> 00:21:15,700
+على تكوين الهرمونات الbody mass index التي لها 
+
+284
+00:21:15,700 --> 00:21:20,020
+علاقة بالضيق تؤثر على الinfertility عند الmale
+
+285
+00:21:20,020 --> 00:21:23,280
+تؤثر على الinfertility عند الmale و عند ال
+
+286
+00:21:23,280 --> 00:21:28,840
+female أيضا في حاجة اسمها الoral contraceptive
+
+287
+00:21:28,840 --> 00:21:32,700
+إذا كان أوcontraception إذا كان بيتم استخدام
+
+288
+00:21:32,700 --> 00:21:36,740
+موانع حمل أو بعض السيدات بتستخدم موانع حمل الoral
+
+289
+00:21:36,740 --> 00:21:41,000
+كالtablet هذا استخدامه بشكل مفرط ولفترات زمنية
+
+290
+00:21:41,000 --> 00:21:45,270
+طويلة يؤدي إلى حدوث مشاكل وعدم استقرار في الدورة
+
+291
+00:21:45,270 --> 00:21:48,450
+الشهرية مما يؤدي إلى التأثير عنinfertility
+
+292
+00:21:48,450 --> 00:21:53,130
+مستقبلا في حالة العودة للتفكير للإنجاب مرة أخرى
+
+293
+00:21:53,130 --> 00:21:56,670
+وقيص عليها اللولب اللي هنتكلم عنه وعن آليات
+
+294
+00:21:56,670 --> 00:22:00,850
+استخدامه وكيفية استخدامه يؤثر علىinfertility and
+
+295
+00:22:00,850 --> 00:22:05,050
+الfemale عشان كده المفروض والمنطق كلsix months
+
+296
+00:22:05,050 --> 00:22:11,620
+يصير عملية تغيير وexamination على موضوع اللولب
+
+297
+00:22:11,620 --> 00:22:15,200
+lifestyle هو من أشهر الlifestyle تأثيرا هي ال
+
+298
+00:22:15,200 --> 00:22:17,960
+smoking طبعا لما أقولsmoking لازم أفصل بين ال
+
+299
+00:22:17,960 --> 00:22:22,340
+male و الfemale لإن الfemale تتأثر بشكل أكبر من
+
+300
+00:22:22,340 --> 00:22:26,120
+الmale لإن الfemale عندها oocyte مخلق أو جاهزة
+
+301
+00:22:26,120 --> 00:22:30,700
+في مرحلة استقرار و ثبات و خمول في مرحلة ال
+
+302
+00:22:30,700 --> 00:22:34,700
+prophase من المقسم الميوزي الأول فدخان السجائر لما
+
+303
+00:22:34,700 --> 00:22:38,740
+ندخل على الجسم هيأثر على المخزن بينما عند الmale
+
+304
+00:22:38,960 --> 00:22:43,920
+الSpermatogenesis كل 73 يوم تخلق كل 60 يوم في
+
+305
+00:22:43,920 --> 00:22:48,260
+حاجة جديدة فبالتالي .. فبالتالي تأثيرها بيكون
+
+306
+00:22:48,260 --> 00:22:53,220
+محدود يختفي التأثير باختفاء المؤثر يعني الmale لو
+
+307
+00:22:53,220 --> 00:22:56,420
+وقف التدخين مدة سنة سنتين حيتها بشوية ولكن هيرجع
+
+308
+00:22:56,420 --> 00:23:01,220
+الreproduction تبعته طبيعية وإنما الfemale مشكلة
+
+309
+00:23:01,220 --> 00:23:07,100
+لأن التأثير موجود على بويضات مخزنة في مرحلة خمول
+
+310
+00:23:07,100 --> 00:23:13,030
+ومرحلة سكونsmoking كان making variation in ovarian
+
+311
+00:23:13,030 --> 00:23:16,930
+function and in the number .. in ovarian function
+
+312
+00:23:16,930 --> 00:23:20,330
+by different way على سبيل المثال الchemical
+
+313
+00:23:20,330 --> 00:23:25,030
+material موجودة في دخان السجائر تؤثر على ال
+
+314
+00:23:25,030 --> 00:23:28,650
+metabolism وتؤثر علىliver metabolism بشكل أساسي
+
+315
+00:23:28,650 --> 00:23:33,230
+تؤثر على steroid hormone لأن الliver كوليسترول
+
+316
+00:23:33,230 --> 00:23:38,720
+كوليسترول يدخل في تكوين يقول في تكوين steroid
+
+317
+00:23:38,720 --> 00:23:41,760
+هورمون steroid هورمون هي عبارة عن الsex hormone
+
+318
+00:23:41,760 --> 00:23:45,020
+اللي عند الmale تتمثل في الtestosterone، الLH،
+
+319
+00:23:45,020 --> 00:23:48,340
+الprogesterone، الoestrogen وعند الfemale الprogesterone
+
+320
+00:23:48,340 --> 00:23:53,440
+فبالتالي هي أحد الطرق التي يؤثر فيها تدخين السجائر
+
+321
+00:23:53,440 --> 00:23:57,400
+على عملية الإنجاب أنه بأثر على الhepatic
+
+322
+00:23:57,400 --> 00:24:01,560
+metabolism أوliver metabolism مما يؤثر على إنشاء
+
+323
+00:24:01,560 --> 00:24:06,180
+وتخليق steroid hormone بعض الدراسات اللي حدثت .. بعض
+
+324
+00:24:06,180 --> 00:24:09,580
+الدراسات اللي حدثت في المختبر وردت إن الchemical
+
+325
+00:24:09,580 --> 00:24:13,260
+material الموجودة في دخان السجائر تؤثر على
+
+326
+00:24:13,260 --> 00:24:18,660
+الإنزيمات اللي بتعمل ويكون مهمة جدا للovarian
+
+327
+00:24:18,660 --> 00:24:22,080
+hormone production علشان يفرز ال .. علشان يفرز
+
+328
+00:24:22,080 --> 00:24:27,020
+مثلا الprogesterone أو يفرز الoestrogen  E2
+
+329
+00:24:27,020 --> 00:24:32,200
+لازم إنزيمات معينة بتعمل للovarian تعملهswitch 
+
+330
+00:24:32,200 --> 00:24:35,890
+on أو تعملهstimulation خلّينا نسميه علشان هذه
+
+331
+00:24:35,890 --> 00:24:40,130
+الهرمونات تفرز فوجدوا أنه دخان السجاير والمواد
+
+332
+00:24:40,130 --> 00:24:43,210
+الكيميائية الموجودة في دخان السجاير تؤثر على هذه
+
+333
+00:24:43,210 --> 00:24:46,910
+الإنزيمات بشكل كبير جدا فظلما أثرت على الإنزيمات
+
+334
+00:24:46,910 --> 00:24:51,770
+إذا الإنزيمات سوف تعمل بشكل غير طبيعي مما يحفظ
+
+335
+00:24:51,770 --> 00:24:56,130
+هرمونات الovarian بشكل غير طبيعي فبتأثر على ال
+
+336
+00:24:56,130 --> 00:25:00,570
+fertility عند الfemale finally الwomen اللي
+
+337
+00:25:00,570 --> 00:25:05,520
+بتدخن مستواهم في بلادنا قليل جدا جدا جدا ولكن في
+
+338
+00:25:05,520 --> 00:25:09,700
+الغرب تعتبر أكثر من الرجال النساء المدخنات أكثر من
+
+339
+00:25:09,700 --> 00:25:14,360
+الرجال في المجتمعات الغربية يعني تقدر تقول أربع كل
+
+340
+00:25:14,360 --> 00:25:18,800
+أربع female واحد male مدخن في المجتمعات الأوروبية
+
+341
+00:25:18,800 --> 00:25:25,260
+السيدة المدخنة تصل إلى مرحلة الearly menopause و
+
+342
+00:25:25,260 --> 00:25:28,120
+قبل السيدة الطبيعية بمعدل سنتين يعني إذا كانت
+
+343
+00:25:28,120 --> 00:25:31,160
+السيدة الطبيعية تصل لأربعين هي ممكن تصل إلى 36 أو
+
+344
+00:25:31,160 --> 00:25:35,550
+37 أو ثمانية أو ثلاثية عشان نكون واضحين ممكن ثلاث
+
+345
+00:25:35,550 --> 00:25:38,650
+سنين وممكن أربع سنين هذا يعتمد على شو؟ يعتمد على
+
+346
+00:25:38,650 --> 00:25:43,770
+الdose قداش بتدخن في اليوم؟ وإيش نوع الدخان
+
+347
+00:25:43,770 --> 00:25:47,530
+كمان؟ مش قداش بتدخن وإيش نوع الدخان؟ لإن في بعض
+
+348
+00:25:47,530 --> 00:25:50,990
+السجائر كمية الchemical material اللي فيها أكثر
+
+349
+00:25:50,990 --> 00:25:57,510
+من أنواع أخرى الكافيينcaffeine intake caffeine intake
+
+350
+00:26:06,200 --> 00:26:10,720
+التجارب تحت التجارب وتحت النقاش ولكن في دراسات
+
+351
+00:26:10,720 --> 00:26:16,040
+كثيرة لنمور بتقول إن استخدام الكافيين بشكل مفرد
+
+352
+00:26:16,040 --> 00:26:18,580
+يؤدي إلى حدوثreduction في الfertility عند ال
+
+353
+00:26:18,580 --> 00:26:21,660
+male و عند الfemale على سبيل المثال لو أنت تناولت
+
+354
+00:26:21,660 --> 00:26:27,620
+كمية تحتوي على caffeine high dose أكثر من 500
+
+355
+00:26:27,620 --> 00:26:31,860
+milligram per day هذا يؤدي إلى عملreduction في ال
+
+356
+00:26:31,860 --> 00:26:35,280
+fertility سواء كانت male أو female نجي لشيء ثاني
+
+357
+00:26:35,280 --> 00:26:40,420
+اللي مش موجود بشكل واضح جدا ولكن موجود في الغرب
+
+358
+00:26:40,420 --> 00:26:43,960
+بشكل كبير جدا الalcohol intake على سبيل المثال ال
+
+359
+00:26:43,960 --> 00:26:48,360
+women who drinking a large amount of alcohol حوالي
+
+360
+00:26:48,360 --> 00:26:53,000
+seven drinks per week أو أكثر من three drinks في
+
+361
+00:26:53,000 --> 00:26:56,980
+الحفلات are more likely to have heavy or irregular
+
+362
+00:26:56,980 --> 00:27:01,610
+period and fertility problem دراسات تم عملها على
+
+363
+00:27:01,610 --> 00:27:05,290
+السيدات المدمنات على الكحول أو اللي بيشرب الكحول
+
+364
+00:27:05,290 --> 00:27:09,830
+وجدوا أن السيدة الطبيعية مسموح لها تقريبا تتناول سبع
+
+365
+00:27:09,830 --> 00:27:15,710
+كؤوس أو ثلاث مرات في أي حفلة إذا زاد هذا المعدل و
+
+366
+00:27:15,710 --> 00:27:20,650
+أصبحت مدمنة بشكل كبير جدا تتناول عشر أو عشرين و
+
+367
+00:27:20,650 --> 00:27:26,710
+طول الحفلة و هي بتعمل alcohol drinking فوجدوا عند
+
+368
+00:27:26,710 --> 00:27:30,110
+هذول السيدات أو هؤلاء السيدات وجدوا أن في عندهم
+
+369
+00:27:30,110 --> 00:27:33,590
+fertility problem بشكل كبير جدا بدأت تغضب ومن
+
+370
+00:27:33,590 --> 00:27:37,490
+أهمها عدم انتظام الدورة الشهرية عدم انتظام الدورة
+
+371
+00:27:37,490 --> 00:27:40,110
+الmenstrual cycle يعني عدم انتظام الovulation
+
+372
+00:27:40,110 --> 00:27:44,730
+عدم انتظام الovulation يعني عدم القدرة على .. عدم
+
+373
+00:27:44,730 --> 00:27:49,370
+القدرة على الإنجاب بالشكل الطبيعي بالشكل الطبيعي ال
+
+374
+00:27:49,370 --> 00:27:52,350
+alcohol can also affected ovulation which can make
+
+375
+00:27:52,350 --> 00:27:57,900
+it difficult to arrive صعب جدا أن أنا أتنبأ متى هو
+
+376
+00:27:57,900 --> 00:28:01,840
+يوم التبويض فبالتالي هيعمل مشكلة في الtime of
+
+377
+00:28:01,840 --> 00:28:06,280
+intercourse stress و الtension أحدث ولا حرج عن ال
+
+378
+00:28:06,280 --> 00:28:09,100
+stress و الtension الstress و الtension دراسات
+
+379
+00:28:09,100 --> 00:28:13,640
+أثبتت أن 40% من الinfertile women هم عبارة عن
+
+380
+00:28:13,640 --> 00:28:18,340
+سيدات يقعن تحت ضغط و قلق بشكل مستمر، لذن ال
+
+381
+00:28:18,340 --> 00:28:22,280
+tension و الstress بلعب دور كبير جدا مش على ال
+
+382
+00:28:22,280 --> 00:28:26,940
+genetic material فقط، بلعب دور واسع على الحالة
+
+383
+00:28:26,940 --> 00:28:31,120
+النفسية عند الزوجة أو عند السيدة بشكل أساسي مما
+
+384
+00:28:31,120 --> 00:28:36,980
+يؤدي إلى فقد الرغبة في الإنجاب مما يؤدي إلى تغيير
+
+385
+00:28:36,980 --> 00:28:40,660
+في الفسيولوجيا الخاصة بالسيدة فعدم انتظام الدورة
+
+386
+00:28:40,660 --> 00:28:45,440
+الشهرية بفعل وجود fluctuation في مستوى الهرمونات
+
+387
+00:28:45,440 --> 00:28:48,220
+التذبذب في مستوى الهرمونات وعدم انتظام مستوى
+
+388
+00:28:48,220 --> 00:28:52,190
+الهرمونات يؤدي إلى عدم انتظام الدورة عدم انتظام
+
+389
+00:28:52,190 --> 00:28:55,490
+الدورة يعني عدم انتظام عملية الovulation عدم
+
+390
+00:28:55,490 --> 00:29:00,190
+انتظام عملية الovulation يعني انقاص فرصة الحصول
+
+391
+00:29:00,190 --> 00:29:06,030
+على حمل هذه عبارة عن العوامل التي تساهم في ال
+
+392
+00:29:06,030 --> 00:29:10,670
+fertility عند الmale و عند الfemale نكتفي بهذا
+
+393
+00:29:10,670 --> 00:29:16,950
+القدر لهذا الأسبوع على أمل أن نلتقي الأسبوع القادم
+
+394
+00:29:16,950 --> 00:29:22,390
+بعنوان جديد getting ready for pregnancy Dom Tom في
+
+395
+00:29:22,390 --> 00:29:23,950
+حفظ الله ورعاية
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/xw35hLAZ8Hg_postprocess.srt b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/xw35hLAZ8Hg_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..c6d86f1b99c4bf5402499946633636efa69720c1
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/xw35hLAZ8Hg_postprocess.srt
@@ -0,0 +1,1580 @@
+1
+00:00:00,720 --> 00:00:04,440
+بسم الله الرحمن الرحيم والصلاة والسلام على أشرف
+
+2
+00:00:04,440 --> 00:00:09,020
+المرسلين سيدنا محمد الصادق الأمين أما بعد بداية
+
+3
+00:00:09,020 --> 00:00:13,940
+نرجو لكم و لنا السلامة في ظل هذه الظروف الصعبة
+
+4
+00:00:13,940 --> 00:00:19,760
+التي نمرضيها جميعاثم نكرر الترحاب بكم في هذا .. في
+
+5
+00:00:19,760 --> 00:00:24,920
+هذا المصطلح الذي بعنوان الحقن المجهري أسبابه، طرقه
+
+6
+00:00:24,920 --> 00:00:29,000
+وأساليبه تحدثنا في المحاضرة السابقة على ال
+
+7
+00:00:29,000 --> 00:00:32,820
+infertility بشكل عام أسبابها عند ال male، أسبابها
+
+8
+00:00:32,820 --> 00:00:37,560
+عند ال female وكل سبب يندرج أسفل منه أكتر من سبب
+
+9
+00:00:38,080 --> 00:00:41,420
+وقفنا في المحاضرة النهائية وفي نهاية المحاضرة
+
+10
+00:00:41,420 --> 00:00:44,780
+السابقة عند مصطلح اسمه Primary Infertility
+
+11
+00:00:44,780 --> 00:00:47,700
+وSecondary Infertility Primary Infertility
+
+12
+00:00:47,700 --> 00:00:51,640
+وSecondary Infertility بشكل أساسي له علاقة بال
+
+13
+00:00:51,640 --> 00:00:56,080
+Female فلما أقول Primary Infertility مصطلح لا يطلق
+
+14
+00:00:56,080 --> 00:01:01,160
+إلا على سيدة لم تنجب ولم تنجب حتى الآن يعني بمعنى
+
+15
+00:01:01,160 --> 00:01:07,330
+آخر زوجة متزوجة من 7 أو 8 أو 9 سنينلم تنجب حتى
+
+16
+00:01:07,330 --> 00:01:11,390
+الآن ولم تنجب فيما سابق يعني محصلة الأطفال
+
+17
+00:01:11,390 --> 00:01:16,830
+الموجودين Zero محصلة حالات الحمض Zero محصلة
+
+18
+00:01:16,830 --> 00:01:20,190
+الإجهاض Zero هذه بسميها Primary Infertility
+
+19
+00:01:20,190 --> 00:01:24,830
+Secondary Infertility حالة تطلق على السيدة التي
+
+20
+00:01:24,830 --> 00:01:29,210
+أصبحت غير قادرة على الإنجاب بعد أن أنجبت قد تكون
+
+21
+00:01:29,210 --> 00:01:32,950
+أنجبت مرة أو مرتين أو تلاتةحاليًا غير قادرة على
+
+22
+00:01:32,950 --> 00:01:36,330
+الإنجابة فبسميها secondary infertility ممكن تكون
+
+23
+00:01:36,330 --> 00:01:39,430
+تعرضت لصدمة ممكن تكون تعرضت لإنسان نفسية طبعًا
+
+24
+00:01:39,430 --> 00:01:42,970
+ممكن تكون تعرضت ل radiotherapy ممكن تكون تعرضت ل
+
+25
+00:01:42,970 --> 00:01:46,490
+chemotherapy كل هذه أسباب تعتبر من العوامل أو
+
+26
+00:01:46,490 --> 00:01:51,090
+الأسباب التي تودي إلى ال secondary infertility أما
+
+27
+00:01:51,090 --> 00:01:55,130
+بالنسبة إلى العوامل التي قد تؤثر على القصوبة تحت
+
+28
+00:01:55,130 --> 00:02:00,890
+عنوانلما أقول infertility يعني بالدرجة تحتها Male
+
+29
+00:02:00,890 --> 00:02:04,470
+and Female أول عامل من العوامل بأثر على ال
+
+30
+00:02:04,470 --> 00:02:09,270
+infertility هي ال maternal age عمر السيدة طبعا عمر
+
+31
+00:02:09,270 --> 00:02:13,790
+السيدة بناء على دراسات سابقة بشكل كتير جدا يلعب
+
+32
+00:02:13,790 --> 00:02:18,570
+دورة أساسية ومهمة في الإنجاب و الحصول على طفل سواء
+
+33
+00:02:18,570 --> 00:02:21,870
+كان الإنجاب الطبيعي أو الإنجاب عن طريق الحقن
+
+34
+00:02:21,870 --> 00:02:27,160
+المجهري لدرجة أن معظم الباحثين تلاشواولم يهتموا
+
+35
+00:02:27,160 --> 00:02:31,800
+بعمر الأب فقالوا أن عمر السيدة وعمر الأنثى هو
+
+36
+00:02:31,800 --> 00:02:36,800
+العمر والمحدد الأساسي لدرجة نجاح عملية الحمل أو
+
+37
+00:02:36,800 --> 00:02:40,980
+درجة نجاح الحقن المجهري من جديد سبع تمان سنين أو
+
+38
+00:02:40,980 --> 00:02:46,860
+ست سنين أصبح لعمر الأب دورة مهمة في عملية نجاح
+
+39
+00:02:46,860 --> 00:02:51,460
+الحقن المجهري أو نجاح عملية التوقيح الطبيعي وأصبحت
+
+40
+00:02:51,460 --> 00:02:55,880
+تكرر الدراسات حول ال paternal age خلينا حاليافي
+
+41
+00:02:55,880 --> 00:02:59,200
+الـ Maternal Age الـ Maternal Age عمر السيدة أو
+
+42
+00:02:59,200 --> 00:03:04,340
+عمر الأم هو العامل الأساسي الذي يؤثر على ال
+
+43
+00:03:04,340 --> 00:03:08,260
+fertility عند ال female كيف بيصير؟ ببساطة جدا
+
+44
+00:03:08,260 --> 00:03:12,440
+بقولك أن ال female تصل إلى ال maximum infertility
+
+45
+00:03:12,440 --> 00:03:15,780
+تبعتها في فترة زمنية معينة تبدأ ال infertility
+
+46
+00:03:15,780 --> 00:03:20,180
+عندها يصيرها decline في 24 سنة يعني بعد أن 24 سنة
+
+47
+00:03:20,180 --> 00:03:22,780
+بيصير ال infertility و الفضل على الإنجاب تقل
+
+48
+00:03:22,780 --> 00:03:28,520
+تدريجياولكن تتسارق هذه العملية في التناقص أو ال
+
+49
+00:03:28,520 --> 00:03:32,840
+infertility تتسارق في التناقص لما تصل ل 37 إذا عند
+
+50
+00:03:32,840 --> 00:03:40,480
+24 بتقل تدريجيا تصل ل 37 بتقل بشكل سريع جدا طبعا
+
+51
+00:03:40,480 --> 00:03:44,800
+مافيش تفسير لهذا الموضوع إلا إما بيصير عندها نقص
+
+52
+00:03:44,800 --> 00:03:49,690
+في عدد البويضاتأو بيصير عندها dysfunctional في ال
+
+53
+00:03:49,690 --> 00:03:53,530
+ovary أو بيصير عندها نقص في ال quality تبع البويضة
+
+54
+00:03:53,530 --> 00:03:56,410
+هذه التلاتة ال theory اللي كانت مطروحة
+
+55
+00:03:56,410 --> 00:04:02,350
+dysfunctional في ال ovary reduction في ال egg
+
+56
+00:04:02,350 --> 00:04:05,830
+quality أو reduction في ال egg quantity هذه
+
+57
+00:04:05,830 --> 00:04:09,430
+التلاتة الفرضيات بشكل أساسي بعض الفحوصات اللتي
+
+58
+00:04:09,430 --> 00:04:15,630
+أجريت على ال model مثل الفئران والأغنام على سبيل
+
+59
+00:04:15,630 --> 00:04:24,300
+المثالوجدوا إن الإناث في سن متأخر يعني 40 مثلا 39
+
+60
+00:04:24,300 --> 00:04:29,100
+.. 37 ابطعتها عدد بويضات وكان هذه عدد البويضات
+
+61
+00:04:29,100 --> 00:04:33,020
+يمكن تلقيحها ولكن بتكون ال quality تبعتها قليلة
+
+62
+00:04:33,020 --> 00:04:39,720
+جدا فطلعوا نظرية وبنتيجة إن عدد البويضات أو
+
+63
+00:04:39,720 --> 00:04:45,180
+السيدات أو الإناث في عمر متأخر جدا يمكن أن تعطي
+
+64
+00:04:45,570 --> 00:04:50,030
+بويضات وهذه البويضات تكون صالحة للإخصاب والتخصيب
+
+65
+00:04:50,030 --> 00:04:54,750
+ولكن ال quality تبعتها بتكون قليلة فتم وضع band
+
+66
+00:04:54,750 --> 00:04:59,690
+أساسي إن ال maternal age له علاقة بشكل أساسي في ال
+
+67
+00:04:59,690 --> 00:05:05,290
+reduction لل egg quality أو ال reduction لل oocyte
+
+68
+00:05:05,290 --> 00:05:09,510
+quality فوجدوا positive correlation ما بين زيادة
+
+69
+00:05:09,510 --> 00:05:14,090
+عفوا وجدوا negative correlation ما بين زيادة عمر
+
+70
+00:05:14,090 --> 00:05:20,780
+السيدةونقصان ال equality تبعت ال oocyte فكلما زاد
+
+71
+00:05:20,780 --> 00:05:24,120
+عمر
+
+72
+00:05:24,120 --> 00:05:28,140
+السيدة قلت ال oocyte equality عشان كده سموها
+
+73
+00:05:28,140 --> 00:05:33,200
+negative correlation على سبيل المثال وجدوا أن
+
+74
+00:05:33,200 --> 00:05:38,100
+الأنثى تولد في فترة أكوين الجنين عندما يكون الجنين
+
+75
+00:05:38,100 --> 00:05:45,200
+أنثى تعمل على إنتاج 7 إلى 6 مليون بوايضةفي الأسبوع
+
+76
+00:05:45,200 --> 00:05:49,020
+رقم 20 من الحمل إذا كان الجانين أنثى يعني إذا كان
+
+77
+00:05:49,020 --> 00:05:53,640
+الجانين أنثى يكون يحتوي في مخزونه من 6 ل 7 مليون
+
+78
+00:05:53,640 --> 00:05:58,720
+هذه البوايضات تستمر في الإنقسام لفترة زمانية معينة
+
+79
+00:05:58,720 --> 00:06:03,020
+تيجي في حاجة نسميها الـ Pro phase في الإنقسام
+
+80
+00:06:03,020 --> 00:06:06,600
+الميوزي الأول هنتكلم عن مراحل انقسام الميوزي الأول
+
+81
+00:06:06,600 --> 00:06:10,060
+ومراحل انقسام الميوزي التاني عند ال male و عند ال
+
+82
+00:06:10,060 --> 00:06:13,680
+female وإيش الفرق ما بينهم في المحاضرات اللاحقة إن
+
+83
+00:06:13,680 --> 00:06:17,930
+شاء اللهولكن أنا بدأ أقول و أؤسس الشغلة إن ال
+
+84
+00:06:17,930 --> 00:06:22,590
+female إذا كان الجنين اللي بداخلها أنفة الجنين
+
+85
+00:06:22,590 --> 00:06:27,530
+الأنفة في الأسبوع رقم 20 يكون يملك من 6 إلى 7
+
+86
+00:06:27,530 --> 00:06:32,030
+مليون بويضة من 6 إلى 7 مليون بويضة هذه البويضة
+
+87
+00:06:32,030 --> 00:06:36,110
+تكون على شكلPrimordial Follicle بسميها في مخزون في
+
+88
+00:06:36,110 --> 00:06:39,310
+منطق بسميها Primordial Follicle بيصير اللي هى
+
+89
+00:06:39,310 --> 00:06:44,330
+Arrested ايقاف في طور معين بيسميه الـ Prophase
+
+90
+00:06:44,330 --> 00:06:48,770
+للميتافيزي للقسام الميوزي الأول لأن عندي فيها قسام
+
+91
+00:06:48,770 --> 00:06:51,590
+ميوزي أول و قسام ميوزي تاني هذه الويضات في مرحلة
+
+92
+00:06:51,590 --> 00:06:56,410
+ال Primordial Follicle تجت في ال Prophase لطور
+
+93
+00:06:56,410 --> 00:07:01,750
+الخاص بالقسام الميوزي الأول بعد فترة من الزمن
+
+94
+00:07:02,330 --> 00:07:05,790
+الكمية كبيرة جداً من 6 إلى 7 مليون بويضة بتروح
+
+95
+00:07:05,790 --> 00:07:09,790
+لمرحلة بسميها atragia ال atragia يعني قتل الخلايا
+
+96
+00:07:09,790 --> 00:07:13,590
+أو موت الخلايا زيها زي ال apoptosis إلى حد ما ولكن
+
+97
+00:07:13,590 --> 00:07:18,350
+في حالة ال Oocyte بسميها atragia فبصير reduction
+
+98
+00:07:18,350 --> 00:07:22,410
+في عدد البويضات من 6 إلى 7 مليون إلى 2 مليون فقط
+
+99
+00:07:22,410 --> 00:07:27,810
+لغير عند .. فقط عندما تولد يعني عندما يولد الجنين
+
+100
+00:07:27,810 --> 00:07:31,990
+الأنثى يصير .. صار عنده atragiaو تناقص لعدد
+
+101
+00:07:31,990 --> 00:07:37,510
+البويضات من سبعة مليون إلى اتنين مليون من عمر يوم
+
+102
+00:07:37,510 --> 00:07:42,930
+واحد حتى سن البلوغ ان سن البلوغ تصير عند السيدة او
+
+103
+00:07:42,930 --> 00:07:47,090
+عند الأنثى فقط سبعمائد الف بويضات لان كمان صار
+
+104
+00:07:47,090 --> 00:07:50,690
+مرحلة تانية من مراحل ال atresia وهي تناقص في عدد
+
+105
+00:07:50,690 --> 00:07:56,090
+البويضات المرحلة التانية كانت من عمر عشرين شهر حتى
+
+106
+00:07:56,090 --> 00:08:00,280
+الميلادوصار فيه تناقص لعدد البوايدات من 7 مليون ل
+
+107
+00:08:00,280 --> 00:08:05,240
+2 مليون المرحلة التانية من الميلاد حتى البلوك صار
+
+108
+00:08:05,240 --> 00:08:10,500
+تناقص من 2 مليون ل 700 ألف بوايدة يعني الأنثى
+
+109
+00:08:10,500 --> 00:08:15,780
+عندما تبلغ و تصل إلى سن الرشد بتكون بتملك 700 ألف
+
+110
+00:08:15,780 --> 00:08:22,760
+بوايدة كل شهر بتنقل بوايدتين أو تلاتة قيس شهر
+
+111
+00:08:22,760 --> 00:08:28,140
+تلاتة في 12في .. لو جولنا على 15 سنة، 15 لحد دي
+
+112
+00:08:28,140 --> 00:08:31,760
+تلقاه الـ 40، شوف أكم سنة و أضرب أكم بويضة، بيصير
+
+113
+00:08:31,760 --> 00:08:37,100
+خسرة هذه السيدة عند سن الـ 37، بيصير عندها مخزون
+
+114
+00:08:37,100 --> 00:08:44,860
+يقدر بـ 25 ألف بويضة فبالتالي، كل ما قدم العمر، في
+
+115
+00:08:44,860 --> 00:08:49,000
+عنده reduction في الـ Oocyte number من خلال
+
+116
+00:08:49,000 --> 00:08:52,380
+التسلسل الزمن اللي شفناهبالإضافة اللى فيه
+
+117
+00:08:52,380 --> 00:08:55,220
+reduction في ال oocyte quality من خلال التجارب
+
+118
+00:08:55,220 --> 00:09:01,060
+اللى أجريت على الفقران و ال animals So there is a
+
+119
+00:09:01,060 --> 00:09:04,520
+high chance that the egg released at ovulation has
+
+120
+00:09:04,520 --> 00:09:08,240
+been abnormal chromosome بقولك كل ما زاد العمر
+
+121
+00:09:08,240 --> 00:09:11,820
+الخاص بال female كل ما زاد العمر خاص بال female
+
+122
+00:09:11,820 --> 00:09:16,800
+فيندي تلت أحداث تصير زيادة في معدل الأتراجيا و هي
+
+123
+00:09:16,800 --> 00:09:22,530
+عبارة عن reduction في عدد البويضاتزيادة في الـ
+
+124
+00:09:22,530 --> 00:09:25,530
+oocyte quality .. الـ oocyte quality بيصير عندها
+
+125
+00:09:25,530 --> 00:09:29,110
+reduction في معدل أو في جودة الـ oocyte بيصير
+
+126
+00:09:29,110 --> 00:09:32,590
+عندها reduction كمان كل ما زاد العمر عند الفemale
+
+127
+00:09:32,590 --> 00:09:36,750
+بلاجي نسبة ال ovulation لبويضات عندها abnormality
+
+128
+00:09:36,750 --> 00:09:39,930
+كرمزومة ال abnormality بتكون عالية جدا و هذا
+
+129
+00:09:39,930 --> 00:09:43,230
+الكرمزومة ال abnormality بتكون بفعل أخطاء خلال
+
+130
+00:09:43,230 --> 00:09:46,910
+انقسام الميوزي .. خلال انقسام الميوزي اذا تلت
+
+131
+00:09:46,910 --> 00:09:53,320
+أسباب و تلت أمور تحدثخلال تطور العمر وزيادة العمر
+
+132
+00:09:53,320 --> 00:09:58,100
+عند السيدة نقصان عدد البويضات نقصان جودة البويضات
+
+133
+00:09:58,100 --> 00:10:03,140
+وزيادة فرصة ظهور بويضات تحمل chromosomal
+
+134
+00:10:03,140 --> 00:10:07,240
+abnormality بفعل لproblem اللي بتصير خلال انقسام
+
+135
+00:10:07,240 --> 00:10:13,540
+الميوزي طيب في أمور تانية ممكن تؤدي وهي عبارة عن
+
+136
+00:10:13,540 --> 00:10:17,460
+ظهور ما يعرف اسم الانبلودي والانبلودي مصطلح يطلق
+
+137
+00:10:17,460 --> 00:10:21,680
+علىمشكلة في عدد الكروموزومات يعني انتصار زيادة في
+
+138
+00:10:21,680 --> 00:10:25,980
+عدد الكروموزومات هذه الأسباب مش معروفة حتى الآن
+
+139
+00:10:25,980 --> 00:10:30,560
+ولكن بعضهم تأثر الانبلويد اللي بتصير في الـVYDATA
+
+140
+00:10:30,560 --> 00:10:34,660
+عند الـAdvanced Age Maternal Advanced Age أول حاجة
+
+141
+00:10:34,660 --> 00:10:39,880
+dysfunctional في الـMetotic Spindle المسؤول عن
+
+142
+00:10:39,880 --> 00:10:45,660
+الـAnaphase ويعبارة عن انقسام الكروموزومات إلى
+
+143
+00:10:46,090 --> 00:10:50,250
+وانفصالهم إلى أقطاب الخلية في مرحلة الـ anaphase
+
+144
+00:10:50,250 --> 00:10:53,050
+يصير في عندي dysfunction في هذه الـ spindle fiber
+
+145
+00:10:53,050 --> 00:10:57,710
+أو بيصير عندي مشكلة في ال adhesion between sister
+
+146
+00:10:57,710 --> 00:11:01,250
+chromatid في حاجة اسمها التصالب والعبور أن الـ two
+
+147
+00:11:01,250 --> 00:11:04,490
+sister chromatid الداخليات بيصير في تبادل لبعض
+
+148
+00:11:04,490 --> 00:11:10,730
+القطع ال DNA فإذا صار في عندي مشكلة في عملية فصل
+
+149
+00:11:10,730 --> 00:11:15,630
+ال sister chromatid معناه يؤدي إلى عمل Anaploidy
+
+150
+00:11:15,760 --> 00:11:18,940
+لأن الكرموزوم الـ 2 copy of الكرموزوم هيروح في
+
+151
+00:11:18,940 --> 00:11:23,200
+اتجاه خلية واحدة فالخلية الأخرى تكون تحتوى على سفر
+
+152
+00:11:23,200 --> 00:11:27,040
+عدد من هذه الكرموزومات تكون تحتوى على سفر عدد من
+
+153
+00:11:27,040 --> 00:11:29,780
+هذه الكرموزومات طبعا الكرموزوم الـ abnormality
+
+154
+00:11:29,780 --> 00:11:35,160
+تستطيع أن تفسر ما يقارب 70 إلى 80% من حالات فقدان
+
+155
+00:11:35,160 --> 00:11:38,640
+الجنين في أول تلات شهور فقدان الجنين في أول تلات
+
+156
+00:11:38,640 --> 00:11:42,840
+شهور 80% من نسبتهميكون سببها chromosomal
+
+157
+00:11:42,840 --> 00:11:50,180
+abnormality دراسة تم إجراءها في مصابق فينت أن
+
+158
+00:11:50,180 --> 00:11:56,100
+الانبلودي كنسبة بتزيد مع زيادة عمر الأم فإذا كانت
+
+159
+00:11:56,100 --> 00:12:02,650
+الأم 30 نسبة الانبلودي 2335 سنة 34% نسبة الانبلودي
+
+160
+00:12:02,650 --> 00:12:10,170
+40 سنة 58% نسبة الانبلودي 45 سنة 84% نسبة
+
+161
+00:12:10,170 --> 00:12:14,470
+الانبلودي فوجدوا ان في عندي positive correlation
+
+162
+00:12:14,470 --> 00:12:19,730
+ما بين عمر الأم ونسبة ظهور الانبلودي كل ما زاد عمر
+
+163
+00:12:19,730 --> 00:12:24,070
+الأم كل ما كانت نسبة ظهور الانبلودي في الجنين أعلى
+
+164
+00:12:24,070 --> 00:12:29,970
+بكافة أي فكرة وسببوعامل من العوامل التي تؤثر عند
+
+165
+00:12:29,970 --> 00:12:32,670
+ال infertility ان ال female وهي ميارة باسم ال
+
+166
+00:12:32,670 --> 00:12:36,330
+maternal age نيجي للشق التاني اللي كان مهمل اسمه
+
+167
+00:12:36,330 --> 00:12:40,730
+paternal age وجدوا على سبيل المثال ان التستستيرون
+
+168
+00:12:40,730 --> 00:12:45,430
+يفرث بشكل مستمر في جسم الإنسان الذكر من أجل تحفيز
+
+169
+00:12:45,430 --> 00:12:50,410
+التستس لإنتاج ال sperm نسبة التستستيرون تقل
+
+170
+00:12:50,410 --> 00:12:55,830
+تدريجيا عن سن الأربعينبدراسة بسيطة على ذكور عمرهم
+
+171
+00:12:55,830 --> 00:13:02,430
+75 سنة وجدوا أن نسبة التستيستيرون عندهم تساوي نصف
+
+172
+00:13:02,430 --> 00:13:06,570
+كمية التستيستيرون في شاب عمره 20 سنة يعني لو أجبت
+
+173
+00:13:06,570 --> 00:13:11,310
+أنا 75 سنة مجموعة ذكور 75 سنة ومجموعة ذكور 20 سنة
+
+174
+00:13:11,310 --> 00:13:14,950
+هألاجي نسبة التستيستيرون كمية التستيستيرون عند
+
+175
+00:13:14,950 --> 00:13:19,070
+الذكور اللي عمرهم 75 وفوج تساوي نصف كمية
+
+176
+00:13:19,070 --> 00:13:24,550
+التستيستيرون اللي عند الذكور عمرهمالتستيستيرون
+
+177
+00:13:24,550 --> 00:13:29,110
+بلعب دورة مهمة في إنتاج الحيوانات المنوية تناقص
+
+178
+00:13:29,110 --> 00:13:33,590
+التستيستيرون بشكل ملحوظ يؤدي إلى reduction في ال
+
+179
+00:13:33,590 --> 00:13:38,190
+sperm count reduction في ال sperm morphology ولكن
+
+180
+00:13:38,190 --> 00:13:42,310
+لا يؤدي إلى انعدام لا يؤدي إلى انعدام فال Siemen
+
+181
+00:13:42,310 --> 00:13:46,090
+parameter وجدوا .. وجدت بعض الدراسات أن Siemen
+
+182
+00:13:46,090 --> 00:13:50,510
+parameter التي قد تتأثر بعمر الذكور هي عبارة عن
+
+183
+00:13:50,510 --> 00:13:54,230
+Siemen Alfolioالـ Semen Volume الـ Motility الـ
+
+184
+00:13:54,230 --> 00:13:57,310
+Normal Morphology وبعضهم جال الـ Sperm Count أو
+
+185
+00:13:57,310 --> 00:14:01,030
+الـ Sperm Concentration فبالدراسات جالت إن والله
+
+186
+00:14:01,030 --> 00:14:05,210
+الـ Age يؤثر تأثيرا سلبيا على الـ Semen Parameters
+
+187
+00:14:05,210 --> 00:14:09,010
+زيادة الـ Age بيؤدي لنقصان الـ Volume ونقصان الـ
+
+188
+00:14:09,010 --> 00:14:11,750
+Sperm Quality ونقصان الـ Sperm Concentration
+
+189
+00:14:11,750 --> 00:14:14,790
+ونقصان الـ Sperm Motility بعض الدراسات خلفت
+
+190
+00:14:14,790 --> 00:14:19,300
+الموضوع دو جالت لأالـ paternal age لا يؤثر سلبيا
+
+191
+00:14:19,300 --> 00:14:22,860
+على الـ semen parameter إذا there is no
+
+192
+00:14:22,860 --> 00:14:27,200
+significant relationship between paternal age and
+
+193
+00:14:27,200 --> 00:14:31,200
+semen parameter هذه دراسة جالت كده ودراسة جالت كده
+
+194
+00:14:31,200 --> 00:14:35,500
+ودراسات حاجت بنفس الشكل ودراسات عاكسات ما تم توصيه
+
+195
+00:14:35,500 --> 00:14:40,160
+الجيل الانبلودي أيضا وجدوا أنه يعتبر عامل أساسي
+
+196
+00:14:40,160 --> 00:14:44,070
+ومهم عند الذكورو يؤثر على ال fertility سواء كان
+
+197
+00:14:44,070 --> 00:14:47,630
+الانبلو دي او ما يُعرف باسم ال diesomy بصلاحة
+
+198
+00:14:47,630 --> 00:14:54,670
+diesomy ببساطة جدا انه استخدال two copy of كرومزوم
+
+199
+00:14:54,670 --> 00:14:59,650
+from the same parent يعني انا حصلت على كرومزوم رقم
+
+200
+00:14:59,650 --> 00:15:03,510
+11 من الأم كرومزوم رقم 11 اللي جاي من الأب مش
+
+201
+00:15:03,510 --> 00:15:08,610
+موجود فده بسمي الحالة diesomy diesomy ببساطة هي
+
+202
+00:15:08,610 --> 00:15:15,270
+حالة تطلق على شخص او imperiumالإمبيريو حصل على كلا
+
+203
+00:15:15,270 --> 00:15:19,290
+النسختين من الكرموزوم معين من مصدر واحد، يا إما
+
+204
+00:15:19,290 --> 00:15:23,830
+كلاهما من الأب أو كلاهما من الأم فوجدوا أن
+
+205
+00:15:23,830 --> 00:15:27,450
+الانبلودي أو الديزومي إذا حدثت في الاسبيرماتوزوفة
+
+206
+00:15:27,450 --> 00:15:32,490
+تؤدي إلى فقدان الحمض، لما يقول pregnancy lose يعني
+
+207
+00:15:32,490 --> 00:15:37,590
+فقدانه في أول تلت شهور من عملية الحمضمعدل
+
+208
+00:15:37,590 --> 00:15:41,690
+الانبلودي في الـ sperm فقط 2% معدل الانبلودي في
+
+209
+00:15:41,690 --> 00:15:47,350
+الـ sperm 2% and there is no evidence to support
+
+210
+00:15:47,350 --> 00:15:51,270
+an increased rate of anabloody involving autosomal
+
+211
+00:15:51,270 --> 00:15:55,930
+in male with advanced age يعني بس فقط معدل
+
+212
+00:15:55,930 --> 00:16:00,670
+الانبلودي حدوثه عند الذكور 2% حتى الآن دراسات
+
+213
+00:16:00,670 --> 00:16:05,450
+قليلة جدا ولا تكاد تذكر اللي دعمت هذه الفرضية أو
+
+214
+00:16:05,450 --> 00:16:12,530
+قالتإن الانبلو يزيد بزيادة عمر الذكر شو السبب؟
+
+215
+00:16:12,530 --> 00:16:18,590
+بمنطق جدا إن الحيوانات المنوية في حالة تخليق وتخلق
+
+216
+00:16:18,590 --> 00:16:23,990
+وإنشاء بشكل مستمر لا تخلق وتخزن لفترة زمنية طويلة
+
+217
+00:16:23,990 --> 00:16:28,790
+جدا لكي يحدث فيها abnormal خلال القسم الميوزي وإن
+
+218
+00:16:28,790 --> 00:16:34,190
+حدث بيصير لها reprogramming بشكل مستمر أو
+
+219
+00:16:34,190 --> 00:16:39,030
+repairingبخلاف الـ Oocyte الـ time of intercourse
+
+220
+00:16:39,030 --> 00:16:43,590
+وقت الاتصال أو وقت الاتصال بين ال male و ال female
+
+221
+00:16:43,590 --> 00:16:48,190
+يعتبر من أهم الأسباب أو العوامل التي تؤثر على ال
+
+222
+00:16:48,190 --> 00:16:52,070
+fertility فكل ما كان وقت ال intercourse بين ال
+
+223
+00:16:52,070 --> 00:16:56,150
+male و ال female الزوج و الزوجة قريب من وقت الطبيب
+
+224
+00:16:56,150 --> 00:17:00,730
+كل ما كانت فرصة ال fertilization أعلىكل ما كانت ال
+
+225
+00:17:00,730 --> 00:17:03,570
+infertility أعلى كل ما كانت فرصة الحصول على
+
+226
+00:17:03,570 --> 00:17:07,810
+pregnancy أعلى بكثير طب شو هو الأيام هذه؟ 12 .. 13
+
+227
+00:17:07,810 --> 00:17:11,650
+.. 14 طبعا تختلف باختلاف ال municipal cycle
+
+228
+00:17:11,650 --> 00:17:17,870
+duration حنتكلم فيها ال biohazard بعض المجتمعات في
+
+229
+00:17:17,870 --> 00:17:21,590
+عندها biohazard بتأثر على ال infertility بشكل كبير
+
+230
+00:17:21,590 --> 00:17:26,860
+خصوصا الناس اللي بتشتغل فيهالمزاريع الناس تشتغل في
+
+231
+00:17:26,860 --> 00:17:29,860
+الزراعة الناس تشتغل في مصانع المبيضات الحشرية
+
+232
+00:17:29,860 --> 00:17:34,220
+تشتغل في مصانع البطاريات تشتغل في مصانع الاسفنج في
+
+233
+00:17:34,220 --> 00:17:38,660
+بعض ال biohazard اللي بتعرضولهم فمن أشهر ال hazard
+
+234
+00:17:38,660 --> 00:17:42,200
+اللي بتعرضهم بعيد عن ال biohazard من أشهرها ال
+
+235
+00:17:42,200 --> 00:17:45,620
+nitrous oxide ال nitrous oxide وجدوا أنه له علاقة
+
+236
+00:17:45,620 --> 00:17:49,280
+بال spontaneous apportion بالإضافة إلى أنه يرتبط
+
+237
+00:17:49,280 --> 00:17:53,800
+رتبطا موثيقا باختزال وتناقص ال fertility عند الميل
+
+238
+00:17:53,800 --> 00:17:58,340
+وعندالـ Female إضافة إلى بعض المواد الكيميائية
+
+239
+00:17:58,340 --> 00:18:02,120
+اللي ممكن نتعرض لها زي المواد الكيميائية الموجودة
+
+240
+00:18:02,120 --> 00:18:06,860
+في السجائر النكوتين والكالميوم المواد الموجودة في
+
+241
+00:18:06,860 --> 00:18:12,460
+البطاريات هذه كلها مواد كيميائية ثقيلة سامة تؤثر
+
+242
+00:18:12,460 --> 00:18:17,380
+على ال infertility بشكل تراكمي .. بشكل تراكمي عند
+
+243
+00:18:17,380 --> 00:18:21,940
+ال male و عند ال female نجي لعمل تاني وهو الضياء
+
+244
+00:18:21,940 --> 00:18:26,060
+الغذاء طبعاعملية الـ eugenesis تخلق البويضات
+
+245
+00:18:26,060 --> 00:18:30,880
+وعملية ال spermogenesis تخلق النطف عند الرجال هي
+
+246
+00:18:30,880 --> 00:18:35,080
+عملية تحتاج إلى مواد غذائية معينة ومركبات معينة زي
+
+247
+00:18:35,080 --> 00:18:38,800
+عصابين مثال لـ spermatozoa عشان تتحرك بتحتاج إلى
+
+248
+00:18:38,800 --> 00:18:42,620
+fractose فهي ممكن يكون عندك كل الأمور طبيعية ماعاد
+
+249
+00:18:42,620 --> 00:18:46,980
+الحركة عندك abnormal، بذكر فتحتاج إلى مواد غذائية
+
+250
+00:18:46,980 --> 00:18:50,760
+تحتوي على ال fractose فبتؤدي إلى تنشيط ال sperm
+
+251
+00:18:50,760 --> 00:18:54,510
+ويمكنه يؤدي إلى تحسينالبرامير تبع ال sperm
+
+252
+00:18:54,510 --> 00:18:57,310
+motility أو ال progressive sperm motility ال
+
+253
+00:18:57,310 --> 00:19:00,490
+progressive sperm motility مصطلح يطلق على ال
+
+254
+00:19:00,490 --> 00:19:04,870
+spermatozoa التي تتحرك بشكل نشط one way one
+
+255
+00:19:04,870 --> 00:19:10,250
+direction فبالتالي الضيط بيلعب دور كبير جدا كمواد
+
+256
+00:19:10,250 --> 00:19:15,430
+غذائية ايضا الضيط ان كان صحي او غير صحي و لو انا
+
+257
+00:19:15,430 --> 00:19:19,170
+بدي افسر الضيط اكتر بدي اعمل دراسة على ال body
+
+258
+00:19:19,170 --> 00:19:24,390
+mass index ال body mass index يعنيفي عندي obese
+
+259
+00:19:24,390 --> 00:19:27,710
+ولا مافيش عنده obese؟ فوجدوا بعض الدراسات وجدت أن
+
+260
+00:19:27,710 --> 00:19:33,410
+ال women with body mass index أقل من 19 or body
+
+261
+00:19:33,410 --> 00:19:39,670
+fat حوالي أقل من 22% هم عبارة عن risk
+
+262
+00:19:39,670 --> 00:19:44,290
+للhypothalamic dysfunction اللي بيأثر على ال
+
+263
+00:19:44,290 --> 00:19:49,190
+ovulation يعني أي سيدة عندها كمية ال fat في جسمها
+
+264
+00:19:49,190 --> 00:19:54,100
+أقل من 22%أو الـ Body Mass Index الخاص فيها أقل من
+
+265
+00:19:54,100 --> 00:19:59,060
+19 معناها بتكون عرضة إلى خلل في الـ Hypothalamus
+
+266
+00:19:59,060 --> 00:20:04,380
+يسمى Hypothalamic dysfunction هذا الخلل يؤثر على
+
+267
+00:20:04,380 --> 00:20:10,040
+الـ ovulation من خلال عمل abnormality في الـ FSH و
+
+268
+00:20:10,040 --> 00:20:16,000
+الـ LH Production at the other way بعض السيدات
+
+269
+00:20:16,000 --> 00:20:19,230
+اللي عندهم زيادة في الـ Body Mass Indexيكون لهم
+
+270
+00:20:19,230 --> 00:20:25,110
+عرضة للإصابة بالـ PCOS اللي سميتها Polycystic
+
+271
+00:20:25,110 --> 00:20:28,150
+Ovarian Syndrome اللي هي عبارة عن الـ follicle
+
+272
+00:20:28,150 --> 00:20:32,510
+بتكون وصلت لمرحلة النضوج الـ Diameter تبعتها 18
+
+273
+00:20:32,510 --> 00:20:36,410
+يعني مرحلة النضوج ولكن فارقة من الداخل طبعا هذا
+
+274
+00:20:36,410 --> 00:20:42,540
+الـ PCOS يكون يؤدي إلى طبعا سبب من أسبابهأو أحد
+
+275
+00:20:42,540 --> 00:20:46,140
+الإلاقات التي تؤدي إليه هي عبارة عن الـ high body
+
+276
+00:20:46,140 --> 00:20:49,520
+mass index أو increasing body mass index فده طبعا
+
+277
+00:20:49,520 --> 00:20:53,020
+بيؤدي إلى ovulation problem أو ovulation
+
+278
+00:20:53,020 --> 00:20:56,440
+dysfunction there is growing evidence that
+
+279
+00:20:56,440 --> 00:20:59,020
+increased body weight itself may be reduce
+
+280
+00:20:59,020 --> 00:21:03,140
+fertility aside from its impact on ovulatory
+
+281
+00:21:03,140 --> 00:21:08,060
+function لذن لمعنى آخر الغذاء من حيث المكونات
+
+282
+00:21:08,060 --> 00:21:12,300
+الغذائية المتواجدة فيه تؤثر على ال ovulationتؤثر
+
+283
+00:21:12,300 --> 00:21:15,700
+على تكوين الهرمونات ال body mass index التي لها
+
+284
+00:21:15,700 --> 00:21:20,020
+علاقة بالضيق تؤثر على ال infertility عند ال male
+
+285
+00:21:20,020 --> 00:21:23,280
+تؤثر على ال infertility عند ال male و عند ال
+
+286
+00:21:23,280 --> 00:21:28,840
+female أيضا في حاجة اسمها ال oral contraceptive
+
+287
+00:21:28,840 --> 00:21:32,700
+اذا كان او contraception اذا كان بيتم استخدام
+
+288
+00:21:32,700 --> 00:21:36,740
+موانع حمل او بعض السيدات بتستخدم موانع حمل ال oral
+
+289
+00:21:36,740 --> 00:21:41,000
+كال tablet هذا استخدامه بشكل مفرط ولفترات زمنية
+
+290
+00:21:41,000 --> 00:21:45,270
+طويلةيودي إلى حدوث مشاكل وعدم استقرار في الدورة
+
+291
+00:21:45,270 --> 00:21:48,450
+الشارية مما يؤدي إلى التأثير عن infertility
+
+292
+00:21:48,450 --> 00:21:53,130
+مستقبلا في حالة العودة للتفكير للإنجاب مرة أخرى
+
+293
+00:21:53,130 --> 00:21:56,670
+وقيص عليها اللولب اللي هنتكلم عنه وعن آليات
+
+294
+00:21:56,670 --> 00:22:00,850
+استخدامه وكيفية استخدامه يوثر على infertility and
+
+295
+00:22:00,850 --> 00:22:05,050
+ال female عشان كده المفروض والمنطق كل six months
+
+296
+00:22:05,050 --> 00:22:11,620
+يصير عملية تغيير و examination على موضوع اللولبال
+
+297
+00:22:11,620 --> 00:22:15,200
+life style هو من أشهر ال life style تأثيرا هي ال
+
+298
+00:22:15,200 --> 00:22:17,960
+smoking طبعا لما أقول smoking لازم أفصل بين ال
+
+299
+00:22:17,960 --> 00:22:22,340
+male و ال female لإن ال female تتأثر بشكل أكبر من
+
+300
+00:22:22,340 --> 00:22:26,120
+ال male لإن ال female عندها أوسايت مخلق أو جاهزة
+
+301
+00:22:26,120 --> 00:22:30,700
+في مرحلة استقرار و ثبات و خمول في مرحلة ال
+
+302
+00:22:30,700 --> 00:22:34,700
+prophase من المقسم الميوزي الأول فدخان السجال لما
+
+303
+00:22:34,700 --> 00:22:38,740
+ندخل على الجسم هيأثر على المخزن بينما عند ال male
+
+304
+00:22:38,960 --> 00:22:43,920
+الـSpermatogenesis كل 73 يوم تخلق كل 60 يوم في
+
+305
+00:22:43,920 --> 00:22:48,260
+حاجة جديدة فبالتالي .. فبالتالي تأثيرها بيكون
+
+306
+00:22:48,260 --> 00:22:53,220
+محدود يختفي التأثير باختفاء المؤثر يعني ال male لو
+
+307
+00:22:53,220 --> 00:22:56,420
+وقف التدخين مدة سنة سنتين حيتها بشوية ولكن هيرجع
+
+308
+00:22:56,420 --> 00:23:01,220
+ال reproduction تبعته طبيعية وإنما ال female مشكلة
+
+309
+00:23:01,220 --> 00:23:07,100
+لأن التأثير موجود على بويضات مخزنة في مرحلة قمول
+
+310
+00:23:07,100 --> 00:23:13,030
+ومرحلة سكونsmoking كان making variation in ovarian
+
+311
+00:23:13,030 --> 00:23:16,930
+function and in the number .. in ovarian function
+
+312
+00:23:16,930 --> 00:23:20,330
+by different way على سبيل المثال ال chemical
+
+313
+00:23:20,330 --> 00:23:25,030
+material موجودة في دخان السجائر تؤثر على ال
+
+314
+00:23:25,030 --> 00:23:28,650
+metabolism وتؤثر على liver metabolism بشكل أساسي
+
+315
+00:23:28,650 --> 00:23:33,230
+تؤثر على citroid hormone لأن ال liver كوليسترول
+
+316
+00:23:33,230 --> 00:23:38,720
+كوليسترول يدخل في تكوينيقول في تكوين سيترويد
+
+317
+00:23:38,720 --> 00:23:41,760
+هورمون سيترويد هورمون هي عبارة عن الـ sex hormone
+
+318
+00:23:41,760 --> 00:23:45,020
+اللي عند المال تتمثل في الافاساتش، الالاتش،
+
+319
+00:23:45,020 --> 00:23:48,340
+الروجسترون، الاستروجين وعند الفيمايل الروجسترون
+
+320
+00:23:48,340 --> 00:23:53,440
+فبالتالي هي أحد الطرق التي يؤثر فيها تدخين السجائر
+
+321
+00:23:53,440 --> 00:23:57,400
+على عملية الإنجاب أنه بأثر على الـ hepatic
+
+322
+00:23:57,400 --> 00:24:01,560
+metabolism أو liver metabolism مما يؤثر على إنشاء
+
+323
+00:24:01,560 --> 00:24:06,180
+وتخليق سيترويد هورمونبعض الدراسات اللي حدثت .. بعض
+
+324
+00:24:06,180 --> 00:24:09,580
+الدراسات اللي حدثت في المختبر وردت إن الـ chemical
+
+325
+00:24:09,580 --> 00:24:13,260
+material الموجودة في دخان السجائر يؤثر على
+
+326
+00:24:13,260 --> 00:24:18,660
+الإنزيمات اللي ابتصل ويكون مهمة جدا للـ ovarian
+
+327
+00:24:18,660 --> 00:24:22,080
+hormone production علشان يفرز ال .. علشان يفرز
+
+328
+00:24:22,080 --> 00:24:27,020
+مثلا البروجسترون أو يفرز الـ E الاستروجين الـ E2
+
+329
+00:24:27,020 --> 00:24:32,200
+لازم إنزيمات معينة ابتصل للـ ovarian تعمله switch
+
+330
+00:24:32,200 --> 00:24:35,890
+onأو تعمله stimulation خلّينا نسميه علشان هذه
+
+331
+00:24:35,890 --> 00:24:40,130
+الهرمونات تفرز فوجدوا أنه دخان السجاير والمواد
+
+332
+00:24:40,130 --> 00:24:43,210
+الكيميائية الموجودة في دخان السجاير تؤثر على هذه
+
+333
+00:24:43,210 --> 00:24:46,910
+الإنزيمات بشكل كبير جدا فظلما أثرت على الإنزيمات
+
+334
+00:24:46,910 --> 00:24:51,770
+إذا الإنزيمات سوف تعمل بشكل غير طبيعي مما يحفظ
+
+335
+00:24:51,770 --> 00:24:56,130
+هرمونات ال ovarian بشكل غير طبيعي فبتأثر على ال
+
+336
+00:24:56,130 --> 00:25:00,570
+fertility عند ال female finally ال women اللي
+
+337
+00:25:00,570 --> 00:25:05,520
+بتدخنمستواهم في بلادنا قليل جدا جدا جدا ولكن في
+
+338
+00:25:05,520 --> 00:25:09,700
+الغرب تعتبر أكتر من الرجال النساء المدخنات أكتر من
+
+339
+00:25:09,700 --> 00:25:14,360
+الرجال في المجتمعات الغربية يعني تقدر تقول أربع كل
+
+340
+00:25:14,360 --> 00:25:18,800
+أربع female واحد male مدخن في المجتمعات الأوروبية
+
+341
+00:25:18,800 --> 00:25:25,260
+السيدة المدخنة تصل إلى مرحلة ال early menopause و
+
+342
+00:25:25,260 --> 00:25:28,120
+جاب للسيدة الطبيعية بمعدل سنتين يعني إذا كانت
+
+343
+00:25:28,120 --> 00:25:31,160
+السيدة الطبيعية تصل لأربين هي ممكن تصل أنت 36 أو
+
+344
+00:25:31,160 --> 00:25:35,550
+37أو تمانية أو تلاتية عشان نكون واضحين ممكن تلت
+
+345
+00:25:35,550 --> 00:25:38,650
+سنين وممكن أربع سنين هذا يعتمد على شو؟ يعتمد على
+
+346
+00:25:38,650 --> 00:25:43,770
+ال dose جداش بالدخن في اليوم؟ وإيش نوع الدخان
+
+347
+00:25:43,770 --> 00:25:47,530
+كمان؟ مش جداش بالدخن وإيش نوع الدخان؟ لإن في بعض
+
+348
+00:25:47,530 --> 00:25:50,990
+السجائر كمية ال chemical material اللي فيها أكثر
+
+349
+00:25:50,990 --> 00:25:57,510
+من أنواع أخرى الكافين كافيين intake كافيين intake
+
+350
+00:26:06,200 --> 00:26:10,720
+التجارب تحت التجارب وتحت النقاش ولكن في دراسات
+
+351
+00:26:10,720 --> 00:26:16,040
+زهرة لنمور بتقول إن استخدام الكفايين بشكل مفرد
+
+352
+00:26:16,040 --> 00:26:18,580
+يودي إلى حدوث reduction في ال fertility عند ال
+
+353
+00:26:18,580 --> 00:26:21,660
+male و عند ال female على سبيل المثال لو أنت تناولت
+
+354
+00:26:21,660 --> 00:26:27,620
+بعام يحتوى على كفين كفايين high dose أكتر من 500
+
+355
+00:26:27,620 --> 00:26:31,860
+milligram per day هذا يودي إلى عمل reduction فيالـ
+
+356
+00:26:31,860 --> 00:26:35,280
+fertility سواء كانت male أو female نجي لشيء تاني
+
+357
+00:26:35,280 --> 00:26:40,420
+اللي مش موجود بشكل واضح وجالي ولكن موجود في الغرب
+
+358
+00:26:40,420 --> 00:26:43,960
+بشكل كبير جدا ال alcohol intake على سبيل المثال ال
+
+359
+00:26:43,960 --> 00:26:48,360
+women who drinking a large amount of alcohol حوالي
+
+360
+00:26:48,360 --> 00:26:53,000
+seven drinks week or more than three drinks في
+
+361
+00:26:53,000 --> 00:26:56,980
+الحفلات are more likely to have heavy or irregular
+
+362
+00:26:56,980 --> 00:27:01,610
+period and fertility problem دراساتتم عملها على
+
+363
+00:27:01,610 --> 00:27:05,290
+السيدات المدمنات اللي بالكحول أو اللي بيشرب الكحول
+
+364
+00:27:05,290 --> 00:27:09,830
+وجدوا أن السيدة الطبيعية مسموحلة تقريبا تتناول سبع
+
+365
+00:27:09,830 --> 00:27:15,710
+كوس أو تلت مرات في أي حفلة إذا زاد هذا المعدل و
+
+366
+00:27:15,710 --> 00:27:20,650
+أصبحت مدمنا بشكل كبير جدا تتناول عشر أو عشرين و
+
+367
+00:27:20,650 --> 00:27:26,710
+طول الحفلة و هي بتعمل alcohol drinkingفوجدوا عند
+
+368
+00:27:26,710 --> 00:27:30,110
+هدول السيدات أو هؤلاء السيدات وجدوا ان في عندهم
+
+369
+00:27:30,110 --> 00:27:33,590
+fertility problem بشكل كبير جدا بدأت تغضب ومن
+
+370
+00:27:33,590 --> 00:27:37,490
+أهمها عدم انتظام الدورة الشهرية عدم انتظام الدورة
+
+371
+00:27:37,490 --> 00:27:40,110
+ال menstrual cycle يعني عدم انتظام ال ovulation
+
+372
+00:27:40,110 --> 00:27:44,730
+عدم انتظام ال ovulation يعني عدم القدرة على .. عدم
+
+373
+00:27:44,730 --> 00:27:49,370
+القدرة على إنجاب بالشكل الطبيعي بالشكل الطبيعي ال
+
+374
+00:27:49,370 --> 00:27:52,350
+alcohol can also affected ovulation which can make
+
+375
+00:27:52,350 --> 00:27:57,900
+it difficult to arriveصعب جدا أن انا أتنبأ متى هو
+
+376
+00:27:57,900 --> 00:28:01,840
+يوم التطوير فبالتالي هيعمل مشكلة في الـtime of
+
+377
+00:28:01,840 --> 00:28:06,280
+intercourse stress و ال tension أحدث ولا حرج عن ال
+
+378
+00:28:06,280 --> 00:28:09,100
+stress و ال tension ال stress و ال tension دراسات
+
+379
+00:28:09,100 --> 00:28:13,640
+أثبتت أن 40% من ال infertile women هم عبارة عن
+
+380
+00:28:13,640 --> 00:28:18,340
+سيدات يقعوا تحت ضغط و قلق بشكل مستمر، لذن ال
+
+381
+00:28:18,340 --> 00:28:22,280
+tension و ال stress بلعب دور كبير جدا مش على ال
+
+382
+00:28:22,280 --> 00:28:26,940
+genetic material فقطلأ، بيلعب دور سيّع على الحالة
+
+383
+00:28:26,940 --> 00:28:31,120
+النفسية عند الزوجة أو عند السيدة بشكل أساسي مما
+
+384
+00:28:31,120 --> 00:28:36,980
+يؤدي إلى فقد الرغبة على الإنجاب مما يؤدي إلى تغيير
+
+385
+00:28:36,980 --> 00:28:40,660
+في السيولوجية الخاصة بالسيدة فعدم انتظام الدورة
+
+386
+00:28:40,660 --> 00:28:45,440
+الشهرية بفعل وجود fluctuation في مستوى الهرمونات
+
+387
+00:28:45,440 --> 00:28:48,220
+التذبذب في مستوى الهرمونات وعدم انتظام مستوى
+
+388
+00:28:48,220 --> 00:28:52,190
+الهرمونات يؤدي إلى عدم انتظام الدورةعدم انتظام
+
+389
+00:28:52,190 --> 00:28:55,490
+الدورة يعني عدم انتظام عملية ال ovulation عدم
+
+390
+00:28:55,490 --> 00:29:00,190
+انتظام عملية ال ovulation يعني انقاس فرصة الحصول
+
+391
+00:29:00,190 --> 00:29:06,030
+على حملة هذه عبارة عن العوامل التي تساهم في ال
+
+392
+00:29:06,030 --> 00:29:10,670
+fertility عند ال male و عند ال female نكتفي بهذا
+
+393
+00:29:10,670 --> 00:29:16,950
+القدر لهذا الأسبوع على أمل أن نتقى الأسبوع القادم
+
+394
+00:29:16,950 --> 00:29:22,390
+بعنوان جديد getting ready for pregnancyDom Tom في
+
+395
+00:29:22,390 --> 00:29:23,950
+حفظ الله ورعاية
+
diff --git a/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/xw35hLAZ8Hg_raw.json b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/xw35hLAZ8Hg_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..5b0b164fcdb9704e6db7c12e2dced52d6be73152
--- /dev/null
+++ b/PL9fwy3NUQKwZ2maYQWAufx8JKyPTiiP30/xw35hLAZ8Hg_raw.json
@@ -0,0 +1 @@
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1724.12, "end": 1725.44, "word": " الهرمونات", "probability": 0.9264090401785714}, {"start": 1725.44, "end": 1726.16, "word": " التذبذب", "probability": 0.814892578125}, {"start": 1726.16, "end": 1726.28, "word": " في", "probability": 0.982421875}, {"start": 1726.28, "end": 1726.6, "word": " مستوى", "probability": 0.9844970703125}, {"start": 1726.6, "end": 1727.12, "word": " الهرمونات", "probability": 0.9806082589285714}, {"start": 1727.12, "end": 1727.48, "word": " وعدم", "probability": 0.9192708333333334}, {"start": 1727.48, "end": 1727.86, "word": " انتظام", "probability": 0.990234375}, {"start": 1727.86, "end": 1728.22, "word": " مستوى", "probability": 0.974365234375}, {"start": 1728.22, "end": 1728.88, "word": " الهرمونات", "probability": 0.9834681919642857}, {"start": 1728.88, "end": 1729.86, "word": " يؤدي", "probability": 0.9256184895833334}, {"start": 1729.86, "end": 1730.1, "word": " إلى", "probability": 0.87939453125}, {"start": 1730.1, "end": 1730.4, "word": " عدم", 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38392, 6055, 3794, 995, 16095, 8978, 2423, 31707, 43242, 2423, 7133, 4032, 43242, 2423, 6556, 8717, 4117, 2655, 41185, 39627, 15730, 25062, 3215, 2288, 46740, 15730, 16247, 35457, 45367, 15844, 5551, 42213, 14739, 8717, 2655, 4587, 7578, 16247, 35457, 45367, 25062, 18513, 2304, 4724, 3615, 1863, 2407, 7649, 10874, 16254, 3215, 1242, 1919, 337, 16120], "avg_logprob": -0.12346421042059222, "compression_ratio": 1.9300411522633745, "no_speech_prob": 3.3974647521972656e-06, "words": [{"start": 1731.49, "end": 1731.87, "word": "عدم", "probability": 0.7646484375}, {"start": 1731.87, "end": 1732.19, "word": " انتظام", "probability": 0.9844970703125}, {"start": 1732.19, "end": 1732.53, "word": " الدورة", "probability": 0.9222005208333334}, {"start": 1732.53, "end": 1732.71, "word": " يعني", "probability": 0.92236328125}, {"start": 1732.71, "end": 1732.95, "word": " عدم", "probability": 0.933349609375}, {"start": 1732.95, "end": 1733.53, "word": " انتظام", "probability": 0.97998046875}, {"start": 1733.53, "end": 1734.03, "word": " عملية", "probability": 0.9718424479166666}, {"start": 1734.03, "end": 1734.19, "word": " ال", "probability": 0.6669921875}, {"start": 1734.19, "end": 1734.71, "word": " ovulation", "probability": 0.59979248046875}, {"start": 1734.71, "end": 1735.49, "word": " عدم", "probability": 0.81591796875}, {"start": 1735.49, "end": 1735.97, "word": " انتظام", "probability": 0.991455078125}, {"start": 1735.97, "end": 1736.29, "word": " عملية", "probability": 0.9903971354166666}, {"start": 1736.29, "end": 1736.41, "word": " ال", "probability": 0.94921875}, {"start": 1736.41, "end": 1736.87, "word": " ovulation", "probability": 0.941162109375}, {"start": 1736.87, "end": 1737.35, "word": " يعني", "probability": 0.968017578125}, {"start": 1737.35, "end": 1738.53, "word": " انقاس", "probability": 0.75830078125}, {"start": 1738.53, "end": 1739.35, "word": " فرصة", "probability": 0.9794921875}, {"start": 1739.35, "end": 1740.19, "word": " الحصول", "probability": 0.9952799479166666}, {"start": 1740.19, "end": 1740.53, "word": " على", "probability": 0.92626953125}, {"start": 1740.53, "end": 1741.23, "word": " حملة", "probability": 0.6394856770833334}, {"start": 1741.23, "end": 1741.89, "word": " هذه", "probability": 0.82373046875}, {"start": 1741.89, "end": 1742.49, "word": " عبارة", "probability": 0.978515625}, {"start": 1742.49, "end": 1742.73, "word": " عن", "probability": 0.99609375}, {"start": 1742.73, "end": 1743.45, "word": " العوامل", "probability": 0.985107421875}, {"start": 1743.45, "end": 1743.97, "word": " التي", "probability": 0.89453125}, {"start": 1743.97, "end": 1745.29, "word": " تساهم", "probability": 0.986083984375}, {"start": 1745.29, "end": 1745.79, "word": " في", "probability": 0.955078125}, {"start": 1745.79, "end": 1746.03, "word": " ال", "probability": 0.67724609375}, {"start": 1746.03, "end": 1746.47, "word": " fertility", "probability": 0.9609375}, {"start": 1746.47, "end": 1746.83, "word": " عند", "probability": 0.908203125}, {"start": 1746.83, "end": 1746.99, "word": " ال", "probability": 0.6201171875}, {"start": 1746.99, "end": 1747.27, "word": " male", "probability": 0.8212890625}, {"start": 1747.27, "end": 1747.67, "word": " و", "probability": 0.98583984375}, {"start": 1747.67, "end": 1747.97, "word": " عند", "probability": 0.73388671875}, {"start": 1747.97, "end": 1748.25, "word": " ال", "probability": 0.90869140625}, {"start": 1748.25, "end": 1748.61, "word": " female", "probability": 0.9501953125}, {"start": 1748.61, "end": 1750.17, "word": " نكتفي", "probability": 0.94970703125}, {"start": 1750.17, "end": 1750.67, "word": " بهذا", "probability": 0.85009765625}, {"start": 1750.67, "end": 1751.19, "word": " القدر", "probability": 0.9742838541666666}, {"start": 1751.19, "end": 1752.63, "word": " لهذا", "probability": 0.8212890625}, {"start": 1752.63, "end": 1753.13, "word": " الأسبوع", "probability": 0.95361328125}, {"start": 1753.13, "end": 1753.97, "word": " على", "probability": 0.81884765625}, {"start": 1753.97, "end": 1754.29, "word": " أمل", "probability": 0.900146484375}, {"start": 1754.29, "end": 1754.53, "word": " أن", "probability": 0.73486328125}, {"start": 1754.53, "end": 1755.09, "word": " نتقى", "probability": 0.73565673828125}, {"start": 1755.09, "end": 1756.37, "word": " الأسبوع", "probability": 0.9578450520833334}, {"start": 1756.37, "end": 1756.95, "word": " القادم", "probability": 0.9931640625}, {"start": 1756.95, "end": 1757.55, "word": " بعنوان", "probability": 0.846484375}, {"start": 1757.55, "end": 1758.11, "word": " جديد", "probability": 0.9908854166666666}, {"start": 1758.11, "end": 1758.51, "word": " getting", "probability": 0.41259765625}, {"start": 1758.51, "end": 1759.15, "word": " ready", "probability": 0.8291015625}, {"start": 1759.15, "end": 1759.69, "word": " for", "probability": 0.96875}, {"start": 1759.69, "end": 1760.21, "word": " pregnancy", "probability": 0.8681640625}], "temperature": 1.0}, {"id": 65, "seek": 176395, "start": 1761.19, "end": 1763.95, "text": "Dom Tom في حفظ الله ورعاية", "tokens": [35, 298, 5041, 8978, 11331, 5172, 19913, 21984, 4032, 2288, 3615, 995, 10632], "avg_logprob": -0.41127231291362215, "compression_ratio": 0.8723404255319149, "no_speech_prob": 0.0, "words": [{"start": 1761.19, "end": 1761.49, "word": "Dom", "probability": 0.592041015625}, {"start": 1761.49, "end": 1761.75, "word": " Tom", "probability": 0.513671875}, {"start": 1761.75, "end": 1762.39, "word": " في", "probability": 0.8818359375}, {"start": 1762.39, "end": 1762.81, "word": " حفظ", "probability": 0.99560546875}, {"start": 1762.81, "end": 1763.17, "word": " الله", "probability": 0.5068359375}, {"start": 1763.17, "end": 1763.95, "word": " ورعاية", "probability": 0.575927734375}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1795.390125, "duration_after_vad": 1737.8556249999965}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/6UTJs0i7Qvc.srt b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/6UTJs0i7Qvc.srt
new file mode 100644
index 0000000000000000000000000000000000000000..edc9f0d1bc87bc5b15cebcb6490de2467f3e5515
--- /dev/null
+++ b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/6UTJs0i7Qvc.srt
@@ -0,0 +1,1119 @@
+
+1
+00:00:13,840 --> 00:00:17,640
+Bismillahirrahmanirrahim Today, inshallah, we are
+
+2
+00:00:17,640 --> 00:00:20,020
+going to continue with definiteness and
+
+3
+00:00:20,020 --> 00:00:23,400
+indefiniteness in English and Arabic. Last time,
+
+4
+00:00:23,420 --> 00:00:25,980
+we spoke about definiteness and indefiniteness in
+
+5
+00:00:25,980 --> 00:00:31,300
+English, and we just touched Arabic a little bit.
+
+6
+00:00:31,400 --> 00:00:34,420
+Today, we are going to go deeply on Arabic
+
+7
+00:00:34,420 --> 00:00:37,640
+definiteness and indefiniteness. And we are going
+
+8
+00:00:37,640 --> 00:00:40,480
+to start with the use of indefinite article in
+
+9
+00:00:40,480 --> 00:00:41,440
+standard Arabic.
+
+10
+00:00:46,510 --> 00:00:49,070
+The indefinite article or the definite article
+
+11
+00:00:49,070 --> 00:00:52,430
+precedes the nouns in Arabic completely like
+
+12
+00:00:52,430 --> 00:00:54,030
+English, okay?
+
+13
+00:00:58,070 --> 00:01:04,610
+The indefinite article, first of all, is zero in
+
+14
+00:01:04,610 --> 00:01:08,590
+Arabic according to some grammarians. Still some
+
+15
+00:01:08,590 --> 00:01:13,510
+others believe that the nonation is indefinite
+
+16
+00:01:13,510 --> 00:01:19,980
+article. رأيت ولدًا يمشي في الشارع I saw a boy
+
+17
+00:01:19,980 --> 00:01:28,660
+walking at the street okay a boy ولدًا so the
+
+18
+00:01:28,660 --> 00:01:34,560
+notation n is considered as indefinite article in
+
+19
+00:01:34,560 --> 00:01:37,540
+Arabic according to some grammarians still some
+
+20
+00:01:37,540 --> 00:01:40,720
+others believe that the indefiniteness in Arabic
+
+21
+00:01:40,720 --> 00:01:44,540
+is zero anyway
+
+22
+00:01:47,390 --> 00:01:49,830
+To introduce indefinite nouns which refer to
+
+23
+00:01:49,830 --> 00:01:52,770
+objects mentioned for the first time in this
+
+24
+00:01:52,770 --> 00:01:56,910
+course The object in the sentence which are
+
+25
+00:01:56,910 --> 00:01:59,010
+mentioned which is mentioned for the first time in
+
+26
+00:01:59,010 --> 00:02:02,330
+the sentence Must be preceded by the indefinite
+
+27
+00:02:02,330 --> 00:02:10,730
+article كان هناك ملك يدعى شهريار Okay
+
+28
+00:02:17,590 --> 00:02:22,630
+Malikun. It is indefinite because it is mentioned
+
+29
+00:02:22,630 --> 00:02:27,290
+for the first time. Once upon a time there was a
+
+30
+00:02:27,290 --> 00:02:31,570
+king called Shahrayar. A king. It is the same like
+
+31
+00:02:31,570 --> 00:02:32,050
+English.
+
+32
+00:02:41,810 --> 00:02:46,290
+Now the indefinite noun Standing as a predicate in
+
+33
+00:02:46,290 --> 00:02:49,930
+the sentence must be preceded by also by
+
+34
+00:02:49,930 --> 00:02:59,010
+indefinite article البيت كبير كبير is a noun okay
+
+35
+00:02:59,010 --> 00:03:04,410
+it's a predicate and
+
+36
+00:03:04,410 --> 00:03:06,870
+is preceded by the indefinite article
+
+37
+00:03:10,130 --> 00:03:14,030
+The nouns here are mainly verbal nouns used as
+
+38
+00:03:14,030 --> 00:03:21,870
+adjectives It
+
+39
+00:03:21,870 --> 00:03:26,550
+is
+
+40
+00:03:26,550 --> 00:03:33,470
+predicate عالم comes from يعلم this is verb okay
+
+41
+00:03:35,420 --> 00:03:39,180
+and works here as a predicate it is preceded by
+
+42
+00:03:39,180 --> 00:03:42,820
+the indefinite article it's preceded by the
+
+43
+00:03:42,820 --> 00:03:47,660
+indefinite article a which is zero or you can
+
+44
+00:03:47,660 --> 00:03:56,340
+consider it the donation on names of
+
+45
+00:03:56,340 --> 00:04:01,250
+professions as we mentioned previously okay I say,
+
+46
+00:04:01,390 --> 00:04:04,250
+for example, once I translate the sentence, the
+
+47
+00:04:04,250 --> 00:04:07,510
+previous sentence, البيت كبير. How could I
+
+48
+00:04:07,510 --> 00:04:11,790
+translate it into English? The house is big. Okay.
+
+49
+00:04:11,870 --> 00:04:18,010
+It's different from English. البيت كبير. Okay. Big
+
+50
+00:04:18,010 --> 00:04:22,330
+is an adjective in English. كبير is a predicate in
+
+51
+00:04:22,330 --> 00:04:26,230
+Arabic preceded by the indefinite article or it
+
+52
+00:04:26,230 --> 00:04:32,940
+has the indefinite article. Zayd is a scientist
+
+53
+00:04:32,940 --> 00:04:36,700
+because this is a profession. I told you that
+
+54
+00:04:36,700 --> 00:04:40,060
+professions and handicrafts are preceded by the
+
+55
+00:04:40,060 --> 00:04:43,260
+indefinite article in English. It is the same in
+
+56
+00:04:43,260 --> 00:04:43,780
+Arabic.
+
+57
+00:04:50,940 --> 00:04:52,920
+We mentioned that in English, we have the
+
+58
+00:04:52,920 --> 00:04:56,360
+professions, the handicrafts and religions are
+
+59
+00:04:56,360 --> 00:05:00,260
+preceded by A or N. In Arabic, we have the same
+
+60
+00:05:00,260 --> 00:05:04,480
+thing. We have zero indefinite article or the
+
+61
+00:05:04,480 --> 00:05:11,640
+nonation on. Zaydun najjarun. Hindun tabibatun.
+
+62
+00:05:13,680 --> 00:05:20,070
+Hind is a lady doctor. Zayd is a junior. A joiner,
+
+63
+00:05:20,170 --> 00:05:22,030
+sorry. Zaid is a joiner.
+
+64
+00:05:28,350 --> 00:05:33,230
+Now, you have the nouns preceded directly by a
+
+65
+00:05:33,230 --> 00:05:38,990
+particle A, the question particle A or A, okay?
+
+66
+00:05:40,230 --> 00:05:44,130
+And the negative particle Ma. The noun following
+
+67
+00:05:44,130 --> 00:05:52,690
+them is always Indefinite أي كتاب قرأت؟ What book
+
+68
+00:05:52,690 --> 00:05:57,430
+did you study? What book did you study? We can't
+
+69
+00:05:57,430 --> 00:06:01,910
+say What a book did you study? What book did you
+
+70
+00:06:01,910 --> 00:06:06,490
+study? This is English however in Arabic أي or أ
+
+71
+00:06:06,490 --> 00:06:09,670
+أقرأت؟
+
+72
+00:06:09,670 --> 00:06:13,250
+Okay Or
+
+73
+00:06:13,250 --> 00:06:17,940
+ما these question particles are followed by nouns
+
+74
+00:06:17,940 --> 00:06:20,980
+if followed by nouns they must these nouns must be
+
+75
+00:06:20,980 --> 00:06:29,620
+indefinite أي كتاب قرأت؟ now
+
+76
+00:06:29,620 --> 00:06:34,420
+once you have nouns expressing wishes they must be
+
+77
+00:06:34,420 --> 00:06:35,100
+indefinite
+
+78
+00:06:45,420 --> 00:06:50,280
+Iqamatun jameelatun Okay, I say in English have a
+
+79
+00:06:50,280 --> 00:06:55,180
+nice day Have a nice day. We mentioned that we
+
+80
+00:06:55,180 --> 00:07:00,300
+have the indefiniteness A or N preceding Wishing
+
+81
+00:07:00,300 --> 00:07:03,700
+or greeting have a nice day. Have a good day. Have
+
+82
+00:07:03,700 --> 00:07:09,080
+a good quiz Okay It is the same in Arabic Iqamatun
+
+83
+00:07:09,080 --> 00:07:09,880
+jameelatun
+
+84
+00:07:15,260 --> 00:07:19,340
+We have also adverbs of circumstances الحال in
+
+85
+00:07:19,340 --> 00:07:24,600
+Arabic and cognate objects المفعول لأجله which are
+
+86
+00:07:24,600 --> 00:07:28,520
+always assigned accusative case along with noun
+
+87
+00:07:28,520 --> 00:07:34,560
+specification تميز الحال
+
+88
+00:07:34,560 --> 00:07:41,280
+and المفعول لأجله in Arabic have indefiniteness
+
+89
+00:07:41,280 --> 00:07:53,890
+جاء الرجل مبتسمًا مبتسما The man came smiling ضرب
+
+90
+00:07:53,890 --> 00:08:02,450
+المعلم الولد ضرب مبرح ضرب
+
+91
+00:08:02,450 --> 00:08:08,070
+مبرح ضرب المعلم الولد ضرب
+
+92
+00:08:21,590 --> 00:08:22,590
+Okay.
+
+93
+00:08:25,370 --> 00:08:30,850
+The teacher hit the boy severely. So you have
+
+94
+00:08:30,850 --> 00:08:34,450
+three
+
+95
+00:08:34,450 --> 00:08:38,750
+elements, adverbs of circumstances, الحال, cognate
+
+96
+00:08:38,750 --> 00:08:42,750
+object, مفعول لأجله and
+
+97
+00:08:44,090 --> 00:08:48,630
+Tamiz, nouns of specification, are always preceded
+
+98
+00:08:48,630 --> 00:08:51,670
+by the indefinite article which is either zero or
+
+99
+00:08:51,670 --> 00:08:52,210
+nonational.
+
+100
+00:08:57,830 --> 00:09:02,590
+We have the indefinite article in Arabic is used
+
+101
+00:09:02,590 --> 00:09:07,050
+directly after ربّة
+
+102
+00:09:14,060 --> 00:09:17,680
+These here are assigned genitive case because you
+
+103
+00:09:17,680 --> 00:09:22,440
+know we have three cases in Arabic Nominative
+
+104
+00:09:22,440 --> 00:09:26,480
+accusative and genitive and the nomination can be
+
+105
+00:09:26,480 --> 00:09:31,060
+nominative can be accusative can be genitive ولد
+
+106
+00:09:31,060 --> 00:09:44,030
+ولد ولد okay رب ضارة نافع رب ضارة نافع ربّة the
+
+107
+00:09:44,030 --> 00:09:49,450
+noun following it is indefinite here ضارة okay
+
+108
+00:09:49,450 --> 00:09:56,350
+perhaps a disaster is useful also the
+
+109
+00:09:56,350 --> 00:10:00,590
+indefiniteness is used with some idiomatic terms
+
+110
+00:10:00,590 --> 00:10:05,590
+in Arabic now
+
+111
+00:10:05,590 --> 00:10:09,690
+we have the definite article in standard Arabic it
+
+112
+00:10:09,690 --> 00:10:13,010
+refers to part Whole relationship.
+
+113
+00:10:19,530 --> 00:10:23,810
+Part-whole relationship. When a part of entity
+
+114
+00:10:23,810 --> 00:10:26,710
+becomes definite in the speaker's mind due to the
+
+115
+00:10:26,710 --> 00:10:31,950
+effect of situational setting. Okay, an example
+
+116
+00:10:31,950 --> 00:10:36,370
+for convenience is represented below. Look, افتح
+
+117
+00:10:36,370 --> 00:10:42,190
+الراديو من فضلك. Radio here is part, whole
+
+118
+00:10:42,190 --> 00:10:46,870
+relationship. It represents an entity. It is seen,
+
+119
+00:10:46,970 --> 00:10:50,230
+it is known by the speaker and the listener. So it
+
+120
+00:10:50,230 --> 00:10:54,550
+is preceded by the indefinite article. Okay? Open
+
+121
+00:10:54,550 --> 00:10:57,410
+the radio please. It is the same like English. We
+
+122
+00:10:57,410 --> 00:11:00,170
+don't say open radio please. Open the radio
+
+123
+00:11:00,170 --> 00:11:04,570
+because you see it is visible. Okay? افتح الراديو
+
+124
+00:11:04,570 --> 00:11:05,250
+من فضلك.
+
+125
+00:11:11,270 --> 00:11:14,990
+Any noun previously mentioned in the paragraph or
+
+126
+00:11:14,990 --> 00:11:17,250
+in this course must be preceded by the definite
+
+127
+00:11:17,250 --> 00:11:30,710
+article Okay,
+
+128
+00:11:32,290 --> 00:11:35,090
+first of all, it is indefinite now once I repeat
+
+129
+00:11:35,090 --> 00:11:41,530
+it becomes الفلم كان الفيلم شيقا جدا I watched a
+
+130
+00:11:41,530 --> 00:11:47,570
+film in the TV. The film was very interesting It's
+
+131
+00:11:47,570 --> 00:11:56,470
+like English a film then the film The
+
+132
+00:11:56,470 --> 00:12:01,250
+noun preceding the relative pronoun or adjectival
+
+133
+00:12:01,250 --> 00:12:07,710
+clauses are always definite in Arabic عاد
+
+134
+00:12:07,710 --> 00:12:16,690
+الرجل الذي سافر إلى لندن I can't say عاد الرجل عاد
+
+135
+00:12:16,690 --> 00:12:22,190
+الرجل الذي الذي is complementizer is relative
+
+136
+00:12:22,190 --> 00:12:26,530
+clause it is like English the man who traveled to
+
+137
+00:12:26,530 --> 00:12:36,850
+London came back the
+
+138
+00:12:36,850 --> 00:12:43,100
+physical stimulus cases have the definite article
+
+139
+00:12:43,100 --> 00:12:50,400
+هذا
+
+140
+00:12:50,400 --> 00:12:54,840
+الرجل جاء لزيارة يعني if you have the
+
+141
+00:12:54,840 --> 00:13:01,020
+demonstrative pronoun هذا الرجل جاء لزيارة this is
+
+142
+00:13:01,020 --> 00:13:06,320
+physical stimulus يعني you see a رجل it is seen I
+
+143
+00:13:06,320 --> 00:13:10,410
+mean the object is seen here هذا الرجل any seen
+
+144
+00:13:10,410 --> 00:13:14,510
+object must have the definite article هذا الرجل
+
+145
+00:13:14,510 --> 00:13:18,570
+جاء لزيارتي. The man came to visit us. This man
+
+146
+00:13:18,570 --> 00:13:20,970
+came to visit us and we have a difference here
+
+147
+00:13:20,970 --> 00:13:26,290
+between Arabic and English هذا الرجل what do you
+
+148
+00:13:26,290 --> 00:13:30,230
+call about what do you call هذا this that these
+
+149
+00:13:30,230 --> 00:13:33,990
+those what do you call this demonstrative pronoun
+
+150
+00:13:33,990 --> 00:13:38,290
+okay it is followed by the definite article how
+
+151
+00:13:38,290 --> 00:13:41,010
+could you translate it into Arabic into English
+
+152
+00:13:41,010 --> 00:13:46,200
+this the man or this man so this means that in
+
+153
+00:13:46,200 --> 00:13:51,060
+English we have a determiner phrase this man this
+
+154
+00:13:51,060 --> 00:13:54,960
+is a determiner demonstrative pronoun however in
+
+155
+00:13:54,960 --> 00:13:59,800
+Arabic we have هذا الرجل هذا is determiner
+
+156
+00:13:59,800 --> 00:14:05,660
+demonstrative pronoun الرجل is another phrase okay
+
+157
+00:14:05,660 --> 00:14:10,740
+we call it article phrase So in Arabic, we have
+
+158
+00:14:10,740 --> 00:14:14,120
+the DB or the terminal phrase followed by an
+
+159
+00:14:14,120 --> 00:14:17,680
+article phrase. Okay, once you have the sentence
+
+160
+00:14:17,680 --> 00:14:21,880
+beginning with a demonstrative pronoun. However,
+
+161
+00:14:21,900 --> 00:14:25,260
+in English, once you translate, you only have the
+
+162
+00:14:25,260 --> 00:14:29,260
+terminal phrase, this man, I can't say this, the
+
+163
+00:14:29,260 --> 00:14:32,320
+man, this man. Okay.
+
+164
+00:14:35,470 --> 00:14:38,770
+So we have here an article, a phrase that is not
+
+165
+00:14:38,770 --> 00:14:42,290
+available in English. It is called article phrase.
+
+166
+00:14:42,850 --> 00:14:44,950
+However, in English, we have what is called
+
+167
+00:14:44,950 --> 00:14:48,690
+determinal phrases, which include the definite and
+
+168
+00:14:48,690 --> 00:14:52,670
+indefinite articles a and the. Okay.
+
+169
+00:15:00,050 --> 00:15:04,090
+So this
+
+170
+00:15:04,090 --> 00:15:04,390
+is
+
+171
+00:15:07,220 --> 00:15:10,520
+the indefinite and definite articles in Arabic.
+
+172
+00:15:10,940 --> 00:15:15,780
+They are the same or nearly similar to English
+
+173
+00:15:15,780 --> 00:15:20,000
+except the zero article which is translated, which
+
+174
+00:15:20,000 --> 00:15:24,200
+is, so any sentence is zero in English must be,
+
+175
+00:15:24,360 --> 00:15:27,040
+any zero article in English is translated to
+
+176
+00:15:27,040 --> 00:15:35,660
+mostly the التعريف in Arabic, okay? We speak about
+
+177
+00:15:35,660 --> 00:15:40,520
+diseases. They are zero. Days. Months. Sports.
+
+178
+00:15:41,000 --> 00:15:45,360
+They are zero in English. Meals. The three times
+
+179
+00:15:45,360 --> 00:15:51,140
+of the day. Morning. Noon. Sunset. Night. I say at
+
+180
+00:15:51,140 --> 00:15:57,040
+night. So these are translated into Alit Ta'rif in
+
+181
+00:15:57,040 --> 00:16:02,160
+Arabic. Now how could you teach articles to your
+
+182
+00:16:02,160 --> 00:16:06,220
+students? They are tricky. And you can see that
+
+183
+00:16:06,220 --> 00:16:09,040
+they are very tricky for the Arab learners because
+
+184
+00:16:09,040 --> 00:16:12,040
+we have differences that may cause negative
+
+185
+00:16:12,040 --> 00:16:15,820
+interference resulting into interlingual errors or
+
+186
+00:16:15,820 --> 00:16:16,840
+interlingual errors.
+
+187
+00:16:22,280 --> 00:16:23,460
+Interlingual errors.
+
+188
+00:16:28,160 --> 00:16:32,500
+Now we
+
+189
+00:16:32,500 --> 00:16:35,490
+come to teaching articles. Okay.
+
+190
+00:16:39,150 --> 00:16:46,050
+Teaching must be contextual. Okay. Because giving
+
+191
+00:16:46,050 --> 00:16:52,570
+your students such a subject with its very overt
+
+192
+00:16:52,570 --> 00:16:55,390
+name, very clear name, definiteness and
+
+193
+00:16:55,390 --> 00:16:58,230
+indefiniteness is very difficult for the junior
+
+194
+00:16:58,230 --> 00:17:03,470
+classes or intermediate or even advanced. Okay. if
+
+195
+00:17:03,470 --> 00:17:06,390
+you teach them in a formal way becomes very
+
+196
+00:17:06,390 --> 00:17:08,790
+complicated however you have to teach them
+
+197
+00:17:08,790 --> 00:17:12,370
+contextually okay connecting between the context
+
+198
+00:17:12,370 --> 00:17:17,230
+and the discourse so teaching pay attention please
+
+199
+00:17:17,230 --> 00:17:22,490
+teaching must be inductive or deductive must be
+
+200
+00:17:22,490 --> 00:17:26,010
+inductive so you have to teach inductively instead
+
+201
+00:17:26,010 --> 00:17:32,300
+of deductively making use of the situation and the
+
+202
+00:17:32,300 --> 00:17:39
+
+223
+00:19:10,110 --> 00:19:14,270
+linguistics. A book. Is this specific or generic?
+
+224
+00:19:16,550 --> 00:19:20,750
+Specific. I'd like to read a book in linguistics.
+
+225
+00:19:22,090 --> 00:19:29,430
+Generic. Okay. We have Language Log Activity Test.
+
+226
+00:19:31,370 --> 00:19:36,110
+The Language Log Activity Test. Here, you have to
+
+227
+00:19:36,110 --> 00:19:42,330
+give homework, and you are not to give everything
+
+228
+00:19:42,330 --> 00:19:46,170
+to your students in the class. You have to let
+
+229
+00:19:46,170 --> 00:19:51,570
+them deduce the rules of articles, either A or the
+
+230
+00:19:51,570 --> 00:20:00,480
+or whatever. Okay? Here, you can introduce the
+
+231
+00:20:00,480 --> 00:20:05,940
+language log this language log exercise is given
+
+232
+00:20:05,940 --> 00:20:10,100
+as assignment to your students it is to be given
+
+233
+00:20:10,100 --> 00:20:16,840
+at home as homework you introduce wrong sentences
+
+234
+00:20:19,440 --> 00:20:22,460
+either the wrong sentences which the students
+
+235
+00:20:22,460 --> 00:20:26,800
+commit during the class, or you can just write
+
+236
+00:20:26,800 --> 00:20:31,560
+sentences with wrong articles, for example. Okay?
+
+237
+00:20:32,100 --> 00:20:37,200
+Then you ask your students to discover the error.
+
+238
+00:20:37,960 --> 00:20:44,800
+Okay? Say, the research, for example. Research is
+
+239
+00:20:44,800 --> 00:20:49,680
+without the. Okay, so they underline that this is
+
+240
+00:20:49,680 --> 00:20:55,400
+the error then the rule Okay, why does research?
+
+241
+00:20:56,620 --> 00:21:03,180
+Cannot cannot take article Okay, so because it is
+
+242
+00:21:03,180 --> 00:21:10,250
+uncountable now Okay Here we have it with zero
+
+243
+00:21:10,250 --> 00:21:14,290
+article. Now you have another space for
+
+244
+00:21:14,290 --> 00:21:18,810
+correction. You say research. Okay. Then you write
+
+245
+00:21:18,810 --> 00:21:22,570
+the sentence, the correct sentence, the correct
+
+246
+00:21:22,570 --> 00:21:32,050
+sentence. I have a son and the daughter. Okay. I
+
+247
+00:21:32,050 --> 00:21:36,690
+have to say, so the mistake is in the. You give
+
+248
+00:21:36,690 --> 00:21:39,690
+the rule. The noun mentioned for the first time is
+
+249
+00:21:39,690 --> 00:21:45,050
+always indefinite. Okay? Once repeated, it is
+
+250
+00:21:45,050 --> 00:21:49,930
+preceded by the. Okay? So I have a son and a
+
+251
+00:21:49,930 --> 00:21:54,410
+daughter. This is done at home. So your students
+
+252
+00:21:54,410 --> 00:21:58,730
+can rely on their parents at home, can rely on
+
+253
+00:21:58,730 --> 00:22:05,170
+anyone. Okay? The family to help them or even
+
+254
+00:22:05,170 --> 00:22:10,110
+their friends. So they can pay sufficient efforts
+
+255
+00:22:10,110 --> 00:22:13,290
+at home for understanding the rules because you
+
+256
+00:22:13,290 --> 00:22:17,790
+are not allowed to give rules in the class. Okay?
+
+257
+00:22:18,090 --> 00:22:21,470
+Because you teach communicatively and the focus is
+
+258
+00:22:21,470 --> 00:22:27,130
+on address rather than giving rules. Okay? So you
+
+259
+00:22:27,130 --> 00:22:30,170
+ask your student to deduce rules at home.
+
+260
+00:22:37,960 --> 00:22:39,680
+Okay. Fine.
+
+261
+00:22:43,480 --> 00:22:48,240
+So we have the
+
+262
+00:22:48,240 --> 00:22:52,440
+articles. Now I'd like to introduce some sentences
+
+263
+00:22:52,440 --> 00:22:56,320
+for you to answer to check your understanding.
+
+264
+00:23:00,120 --> 00:23:05,600
+Can you pass sugar, please? The sugar. Why?
+
+265
+00:23:05,740 --> 00:23:12,100
+Because this is visible. Okay? He's sailing up
+
+266
+00:23:12,100 --> 00:23:19,260
+the Nile for holidays. Nile. He's sailing up the Nile for
+
+267
+00:23:19,260 --> 00:23:24,570
+holidays. The Nile. Why? Because we told you that
+
+268
+00:23:24,570 --> 00:23:28,890
+seas, oceans, and rivers are preceded by the
+
+269
+00:23:28,890 --> 00:23:34,130
+definite article, the. My favorite sea is
+
+270
+00:23:34,130 --> 00:23:37,770
+the Mediterranean Sea. The Mediterranean Sea.
+
+271
+00:23:40,910 --> 00:23:46,630
+I'd love to visit Jerusalem. Jerusalem. Country,
+
+272
+00:23:46,790 --> 00:23:52,400
+country. So proper nouns, proper nouns,
+
+273
+00:23:52,500 --> 00:23:56,340
+geographical names are always zero except, except
+
+274
+00:23:56,340 --> 00:24:00,280
+we say the Sudan or any compound noun.
+
+275
+00:24:04,440 --> 00:24:13,140
+He is the man who lives next door. He is the man who
+
+276
+00:24:13,140 --> 00:24:23,510
+lives next door. okay because he is known yes we
+
+277
+00:24:23,510 --> 00:24:27,530
+have the relative clause who then we have a man
+
+278
+00:24:27,530 --> 00:24:31,390
+preceding it so we have either the it can be a or
+
+279
+00:24:31,390 --> 00:24:37,710
+n but mostly the okay i have been looking for work
+
+280
+00:24:37,710 --> 00:24:46,520
+for a long time i have been looking for work Or a
+
+281
+00:24:46,520 --> 00:24:51,800
+work or the work. A work. Or work or the work.
+
+282
+00:24:52,400 --> 00:24:53,980
+Work. It is zero.
+
+283
+00:24:57,080 --> 00:25:06,840
+I say work.
+
+284
+00:25:07,040 --> 00:25:12,580
+This is uncountable. This is abstract now. Okay?
+
+285
+00:25:13,840 --> 00:25:20,000
+It is generic. I am looking for any work. Okay. I
+
+286
+00:25:20,000 --> 00:25:23,300
+say London Zoo. Do they say the London Zoo or
+
+287
+00:25:23,300 --> 00:25:28,060
+London Zoo? London Zoo. It is zero. Lake Victoria.
+
+288
+00:25:28,780 --> 00:25:36,680
+The lake Victoria. Lake is very large. The lake is
+
+289
+00:25:36,680 --> 00:25:42,380
+very large. I say London Zoo. It is zero. British
+
+290
+00:25:42,380 --> 00:25:48,210
+Museum. The British Museum. The British Museum,
+
+291
+00:25:48,350 --> 00:25:48,590
+why?
+
+292
+00:25:51,450 --> 00:25:57,950
+Because it is very famous and known for both the
+
+293
+00:25:57,950 --> 00:26:00,610
+speaker and the listener. Like once I say, for
+
+294
+00:26:00,610 --> 00:26:04,570
+example, the Parliament. The White House. The
+
+295
+00:26:04,570 --> 00:26:07,210
+White House. The Prime Minister. The Prime
+
+296
+00:26:07,210 --> 00:26:15,350
+Minister. Okay. Professor is absent today. The
+
+297
+00:26:15,350 --> 00:26:17,950
+professor is absent today because it is known for
+
+298
+00:26:17,950 --> 00:26:20,710
+both the speaker and the listener.
+
+299
+00:26:23,890 --> 00:26:24,650
+Okay.
+
+300
+00:26:32,790 --> 00:26:37,210
+I need you to answer the following quiz.
diff --git a/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/9KEnfN0oPFw.srt b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/9KEnfN0oPFw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..fdd50073aba79cbb4a68a99441b021214981156e
--- /dev/null
+++ b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/9KEnfN0oPFw.srt
@@ -0,0 +1,1697 @@
+
+1
+00:00:14,920 --> 00:00:21,860
+Today we are going to touch some 
+
+2
+00:00:21,860 --> 00:00:27,650
+verb constructions specifically futurity. We are
+
+3
+00:00:27,650 --> 00:00:30,790
+going to speak about the future constructions in
+
+4
+00:00:30,790 --> 00:00:35,790
+English and Arabic. This will cover future simple,
+
+5
+00:00:36,910 --> 00:00:44,350
+future continuous, future perfect continuous,
+
+6
+00:00:45,170 --> 00:00:53,530
+future perfect. And the constructions going to, be 
+
+7
+00:00:53,530 --> 00:00:58,820
+to, about to, and also the present simple, which
+
+8
+00:00:58,820 --> 00:01:02,940
+denotes future, and the present continuous, which
+
+9
+00:01:02,940 --> 00:01:06,640
+also denotes future. We are going to speak about
+
+10
+00:01:06,640 --> 00:01:09,680
+these constructions in English, and then we need
+
+11
+00:01:09,680 --> 00:01:15,180
+to touch their counterparts in Arabic. Okay? As
+
+12
+00:01:15,180 --> 00:01:21,740
+you see, future simple. First of all, will attend.
+
+13
+00:01:22,780 --> 00:01:27,460
+What does this construction consist of? What does
+
+14
+00:01:27,460 --> 00:01:31,580
+it consist of? Will, what do you call will? Tense
+
+15
+00:01:31,580 --> 00:01:37,140
+or aspect or whatever? Tense. It is tense. I will
+
+16
+00:01:37,140 --> 00:01:42,420
+attend the lecture. Will is tense. Attend? Aspect. 
+
+17
+00:01:42,580 --> 00:01:48,340
+Simple aspect. So the future simple consists of
+
+18
+00:01:48,340 --> 00:01:54,460
+tense plus simple aspect. Okay?
+
+19
+00:02:00,380 --> 00:02:05,860
+Now, semantically, future simple denotes
+
+20
+00:02:05,860 --> 00:02:11,100
+colorless, neutral future. It refers to open
+
+21
+00:02:11,100 --> 00:02:17,680
+future, neutral future. I shall be 47 years old by 
+
+22
+00:02:17,680 --> 00:02:18,600
+next birthday. 
+
+23
+00:02:22,620 --> 00:02:28,580
+Shall be. It's open. You'll be pleased to see 
+
+24
+00:02:28,580 --> 00:02:33,100
+them. When? We don't know. Will be, please. Will 
+
+25
+00:02:33,100 --> 00:02:38,160
+be. Okay? It's neutral and colorless. There is no
+
+26
+00:02:38,160 --> 00:02:42,520
+distinction of or determination of any exact time.
+
+27
+00:02:43,040 --> 00:02:44,720
+But the meaning is in future. 
+
+28
+00:02:52,320 --> 00:02:58,080
+Now, will and shall plus
+
+29
+00:02:59,160 --> 00:03:02,760
+infinitive without two, these are the constructions
+
+30
+00:03:02,760 --> 00:03:08,520
+of future simple, will shall plus the stem of the
+
+31
+00:03:08,520 --> 00:03:15,340
+verb now, will is used with all pronouns, with all
+
+32
+00:03:15,340 --> 00:03:22,660
+nouns. Once we express determination, okay, or
+
+33
+00:03:22,660 --> 00:03:28,900
+persistence, I'll be opaque, I will be opaque. I will
+
+34
+00:03:28,900 --> 00:03:35,260
+be obeyed. Okay. So this is determination. I am
+
+35
+00:03:35,260 --> 00:03:40,460
+determined to be obeyed. He will do as he likes. 
+
+36
+00:03:41,780 --> 00:03:47,760
+He is determined to do as he likes. Okay. He will
+
+37
+00:03:47,760 --> 00:03:51,020
+do. I will be obeyed. Okay.
+
+38
+00:04:07,020 --> 00:04:12,860
+Now, we have different functions for future 
+
+39
+00:04:12,860 --> 00:04:16,700
+simple. It refers to willingness. 
+
+40
+00:04:23,160 --> 00:04:28,600
+Once you need to or like to do something in
+
+41
+00:04:28,600 --> 00:04:34,080
+future, so you use future simple. Here we have
+
+42
+00:04:34,080 --> 00:04:39,100
+shall, is used to express willingness on the part
+
+43
+00:04:39,100 --> 00:04:42,760
+of the speaker, and the second and third person. Shall is
+
+44
+00:04:42,760 --> 00:04:46,060
+used with the second and third person while will
+
+45
+00:04:46,060 --> 00:04:50,620
+is with the first person. He shall return the good 
+
+46
+00:04:50,620 --> 00:04:57,200
+to the store and refund his money. He shall, shall 
+
+47
+00:04:57,200 --> 00:05:01,470
+he refers to willingness. He shall return the good 
+
+48
+00:05:01,470 --> 00:05:05,910
+to the store and refund his money. This means that
+
+49
+00:05:05,910 --> 00:05:09,950
+he is willing to return the good to the store just
+
+50
+00:05:09,950 --> 00:05:16,830
+to refund his money back. Okay? So we have shall 
+
+51
+00:05:16,830 --> 00:05:24,810
+with he, she, it, they, and you. Okay? In case of
+
+52
+00:05:24,810 --> 00:05:25,710
+willingness.
+
+53
+00:05:27,860 --> 00:05:31,920
+You shall behave as you like. You shall behave as
+
+54
+00:05:31,920 --> 00:05:39,720
+you like. Okay, also future simple expresses offer
+
+55
+00:05:39,720 --> 00:05:45,360
+Shall I give you a lift? Shall I give you a lift
+
+56
+00:05:45,360 --> 00:05:50,140
+Shall with the first person. Shall I, shall I offer
+
+57
+00:05:50,140 --> 00:05:53,720
+you another chance? Shall I offer you another
+
+58
+00:05:53,720 --> 00:06:00,420
+chance? Will you have a rest for 10 minutes? Shall 
+
+59
+00:06:00,420 --> 00:06:06,200
+she make you a cup of tea? Shall she make you a
+
+60
+00:06:06,200 --> 00:06:10,920
+cup of tea? So we have here different semantic
+
+61
+00:06:10,920 --> 00:06:15,400
+functions for the use of future simple. Okay? It
+
+62
+00:06:15,400 --> 00:06:20,780
+refers to open and neutral, colorless future. It 
+
+63
+00:06:20,780 --> 00:06:27,130
+refers to willingness and offer, promise, threat,
+
+64
+00:06:27,670 --> 00:06:30,990
+and other functions. Let's see. We spoke about 
+
+65
+00:06:30,990 --> 00:06:31,430
+willingness. 
+
+66
+00:06:34,990 --> 00:06:37,650
+Who could translate into English? 
+
+67
+00:06:45,370 --> 00:06:49,730
+How could 
+
+68
+00:06:49,730 --> 00:06:52,770
+I translate the word targab or yargab, the verb 
+
+69
+00:06:52,770 --> 00:06:53,250
+yargab? 
+
+70
+00:06:56,690 --> 00:07:01,110
+She shall return the good to the store and refund
+
+71
+00:07:01,110 --> 00:07:05,310
+her money. Okay? Since we have the sense of
+
+72
+00:07:05,310 --> 00:07:11,030
+yarghab, desire, we translate into shall. Shall
+
+73
+00:07:11,030 --> 00:07:14,510
+plus the stem. She shall return the good to the 
+
+74
+00:07:14,510 --> 00:07:19,910
+store. Okay? Ofal. Shall I give you another chance 
+
+75
+00:07:19,910 --> 00:07:25,410
+to read the chapter again? Shall I give you
+
+76
+00:07:25,410 --> 00:07:29,970
+another chance? Shall I give you another chance? 
+
+77
+00:07:30,090 --> 00:07:33,290
+Shall I give you a lift? Shall I give you a lift? 
+
+78
+00:07:34,170 --> 00:07:34,590
+Okay? 
+
+79
+00:07:42,010 --> 00:07:44,130
+Now we have determination.
+
+80
+00:07:46,850 --> 00:07:47,410
+Okay? 
+
+81
+00:07:50,890 --> 00:07:56,700
+I shall do what I like. I am determined to do what
+
+82
+00:07:56,700 --> 00:08:00,260
+I would like to do. Okay?
+
+83
+00:08:04,800 --> 00:08:09,700
+We have also promise. Promise is expressed by
+
+84
+00:08:09,700 --> 00:08:13,980
+future simple. You shall be punished if you do
+
+85
+00:08:13,980 --> 00:08:17,220
+that again. Promise and threat here.
+
+86
+00:08:19,040 --> 00:08:21,000
+We use shall.
+
+87
+00:08:24,560 --> 00:08:31,800
+and will, okay? But here we have shall for some 
+
+88
+00:08:31,800 --> 00:08:38,140
+pronouns and will for other pronouns. So the
+
+89
+00:08:38,140 --> 00:08:41,760
+future simple here can be expressed in the second
+
+90
+00:08:41,760 --> 00:08:45,400
+and third person by shall, and in the first person
+
+91
+00:08:45,400 --> 00:08:50,610
+by will, completely like willingness. Shall takes
+
+92
+00:08:50,610 --> 00:08:53,990
+the second, takes the second and third person while
+
+93
+00:08:53,990 --> 00:08:58,310
+will the first person once we express promise and
+
+94
+00:08:58,310 --> 00:09:02,310
+threat. You shall be punished if you do that again.
+
+95
+00:09:02,310 --> 00:09:08,310
+Shall be punished with
+
+96
+00:09:08,310 --> 00:09:14,270
+you. I'll be there to help. This is a promise. I'll be 
+
+97
+00:09:14,270 --> 00:09:20,880
+there to help, will with I, okay? Is to express
+
+98
+00:09:20,880 --> 00:09:24,740
+promise and the first sentence to express threat 
+
+99
+00:09:24,740 --> 00:09:28,460
+also.
+
+100
+00:09:28,460 --> 00:09:33,440
+We have future simple expressing request in the
+
+101
+00:09:33,440 --> 00:09:39,300
+present and future, you use will with the second 
+
+102
+00:09:39,300 --> 00:09:44,700
+person, will with the second person, once you ask
+
+103
+00:09:44,700 --> 00:09:48,440
+someone, you ask the second person face to face.
+
+104
+00:09:49,560 --> 00:09:52,900
+Will you please open the door? Will you please
+
+105
+00:09:52,900 --> 00:09:58,120
+open the door? Will you, don't say shall you, will
+
+106
+00:09:58,120 --> 00:10:02,360
+you please open the door? Okay. This is a request. 
+
+107
+00:10:03,080 --> 00:10:07,280
+Will you kindly send me an application form? Will 
+
+108
+00:10:07,280 --> 00:10:10,880
+you kindly send me an application form? Will you 
+
+109
+00:10:10,880 --> 00:10:15,100
+kindly send me? Yes. 
+
+110
+00:10:20,990 --> 00:10:26,110
+Yes, shall in case of promise, threat, and
+
+111
+00:10:26,110 --> 00:10:29,990
+willingness, as well with the second and third 
+
+112
+00:10:29,990 --> 00:10:36,670
+person. Request, the first person, we use will, not
+
+113
+00:10:36,670 --> 00:10:42,510
+shall. Sorry, yes, the second person. Will takes
+
+114
+00:10:42,510 --> 00:10:49,430
+you in case of request. Will comes with the second 
+
+115
+00:10:49,430 --> 00:10:52,790
+person. Yes. However, in case of willingness,
+
+116
+00:10:53,470 --> 00:10:59,250
+threat, or promise, okay, you use shall with the 
+
+117
+00:10:59,250 --> 00:11:02,170
+second and third person. Once you have offer, 
+
+118
+00:11:05,310 --> 00:11:09,390
+you use shall with the first person. You offer 
+
+119
+00:11:09,390 --> 00:11:12,550
+something to someone. Shall I offer you a lift?
+
+120
+00:11:13,410 --> 00:11:23,250
+Shall I offer you another chance? You see, now
+
+121
+00:11:23,250 --> 00:11:27,530
+future simple, as you see, refers to neutral
+
+122
+00:11:27,530 --> 00:11:38,750
+colorless, open future. Okay. Open. It is future
+
+123
+00:11:38,750 --> 00:11:45,170
+simple. Is open, colorless, and neutral. It refers to
+
+124
+00:11:46,300 --> 00:11:52,860
+First of all, promise, willingness, threat, offer,
+
+125
+00:11:53,660 --> 00:11:58,760
+and request, plus determination. Okay, do you have
+
+126
+00:11:58,760 --> 00:12:01,880
+the same meanings in Arabic? What about the future 
+
+127
+00:12:01,880 --> 00:12:04,100
+simple? Do you have future simple in Arabic, or
+
+128
+00:12:04,100 --> 00:12:09,470
+not? Okay, let's see. We have future simple in
+
+129
+00:12:09,470 --> 00:12:15,010
+Arabic, it is expressed by sawfa. Sawfa refers to
+
+130
+00:12:15,010 --> 00:12:21,270
+remote future, remote future, not near future. We 
+
+131
+00:12:21,270 --> 00:12:27,950
+say for the near future, we say sa. So sawfa 
+
+132
+00:12:27,950 --> 00:12:33,130
+yusafir Uzaydum ila misra mustaqbalan. When? We
+
+133
+00:12:33,130 --> 00:12:37,300
+don't know, it is open. Colorless and neutral.
+
+134
+00:12:37,900 --> 00:12:46,100
+Okay. It's like English. We have the imperfect
+
+135
+00:12:46,100 --> 00:12:48,400
+indicative form of the verb. 
+
+136
+00:12:51,040 --> 00:12:56,200
+The present imperfect indicative form of the verb.
+
+137
+00:12:57,600 --> 00:12:58,800
+Okay.
+
+138
+00:13:03,790 --> 00:13:07,530
+Remember that in English, we use the stem of the
+
+139
+00:13:07,530 --> 00:13:12,390
+verb. Okay, and the first conjugation of the verb
+
+140
+00:13:12,390 --> 00:13:20,690
+the bare infinitive. However, in English, we use the
+
+141
+00:13:20,690 --> 00:13:24,690
+present imperfect indicative form, with the
+
+142
+00:13:24,690 --> 00:13:32,710
+inflection, ي, يسافر. You can't say, سافرة, يسافر. Okay.
+
+143
+00:13:33,230 --> 00:13:38,270
+This is the future in Arabic. Okay.
+
+144
+00:13:45,090 --> 00:13:51,150
+Here, we have once, we have nom. This is for
+
+145
+00:13:51,150 --> 00:13:54,570
+nominative case. We have three inflections, as we
+
+146
+00:13:54,570 --> 00:13:58,930
+mentioned, nominative case, accusative and
+
+147
+00:13:58,930 --> 00:13:59,770
+genitive case.
+
+148
+00:14:05,420 --> 00:14:09,440
+يريد زيدن, we have here willingness, the future 
+
+149
+00:14:09,440 --> 00:14:13,560
+simple in Arabic also expresses willingness, يريد
+
+150
+00:14:13,560 --> 00:14:21,140
+زيدن أن يعيد البضاعة, يريد زيدن أن يعيد البضاعة 
+
+151
+00:14:21,140 --> 00:14:26,700
+Here we have the imperfect indicative form of the
+
+152
+00:14:26,700 --> 00:14:30,880
+verb, followed by the complementizer أن, or the 
+
+153
+00:14:30,880 --> 00:14:34,920
+derived nominal, إعادة. 
+
+154
+00:14:35,860 --> 00:14:40,380
+Okay. يعيد, إعادة, derived nominal, معناها المصدر, يعني
+
+155
+00:14:40,380 --> 00:14:48,780
+المصدر من يعيد, إعادة. يريد زيدون إعادة البضاعة, يريد 
+
+156
+00:14:48,780 --> 00:14:53,120
+زيدون أن يعيد البضاعة, and is called complementizer
+
+157
+00:14:53,120 --> 00:14:56,260
+يعني relative pronoun
+
+158
+00:15:01,550 --> 00:15:06,250
+Zaid shall retain the good. Why do I use shall
+
+159
+00:15:06,250 --> 00:15:11,910
+here in translation? Why didn't I say Zaid will
+
+160
+00:15:11,910 --> 00:15:16,510
+retain the good? Because shall here expresses 
+
+161
+00:15:16,510 --> 00:15:24,210
+what? Willingness. In Arabic, it is يرغب, or يريد. 
+
+162
+00:15:26,150 --> 00:15:31,680
+يريد زيد إعادة البضاعة. What do you call about? 
+
+163
+00:15:31,860 --> 00:15:35,280
+What do you call it? Derived nominal. 
+
+164
+00:15:37,880 --> 00:15:50,700
+Now we
+
+165
+00:15:50,700 --> 00:15:54,800
+have other 
+
+166
+00:15:54,800 --> 00:16:01,120
+uses for the future simple in Arabic. أريد أن
+
+167
+00:16:01,120 --> 00:16:19,540
+أمنحك فرصة أخرى. أريد
+
+168
+00:16:19,540 --> 00:16:23,200
+أن
+
+169
+00:16:23,200 --> 00:16:28,440
+أمنحك. So, we have the willingness verb, أريد, or أرغب 
+
+170
+00:16:28,440 --> 00:16:36,420
+plus the complementizer أن, plus the verb, يمنح, أمنح 
+
+171
+00:16:36,420 --> 00:16:44,600
+تمنح, نمنح, okay. Also we have the willingness
+
+172
+00:16:44,600 --> 00:16:53,100
+verb, أريد, or يرغب, plus the derived nominal, منح 
+
+173
+00:16:55,900 --> 00:17:05,020
+I shall offer you
+
+174
+00:17:05,020 --> 00:17:14,980
+another chance
+
+175
+00:17:14,980 --> 00:17:20,400
+Okay. Is this correct? I shall offer you another
+
+176
+00:17:20,400 --> 00:17:20,860
+chance.
+
+177
+00:17:25,000 --> 00:17:28,320
+Shall I offer? It is willingness. It is offer.
+
+178
+00:17:28,800 --> 00:17:32,240
+Once we have offer, we use shall with the first 
+
+179
+00:17:32,240 --> 00:17:37,060
+person. Yes. I shall offer you another chance. 
+
+180
+00:17:41,140 --> 00:17:46,440
+Do you want a cup of tea? Do you want soup? What
+
+181
+00:17:46,440 --> 00:17:52,570
+do you call soup? Derived nominal. Okay. So, we
+
+182
+00:17:52,570 --> 00:17:55,470
+have you read, plus, derived nominal, this expresses
+
+183
+00:17:55,470 --> 00:18:00,710
+offer in English. Will you want to drink a cup of
+
+184
+00:18:00,710 --> 00:18:00,950
+tea? 
+
+185
+00:18:07,830 --> 00:18:13,960
+So, we have differences between the future simple 
+
+186
+00:18:13,960 --> 00:18:17,920
+in English, and the future simple in Arabic. Both
+
+187
+00:18:17,920 --> 00:18:23,020
+exist in both languages. However, the future simple
+
+188
+00:18:23,020 --> 00:18:26,840
+is expressed syntactically in English, by using 
+
+189
+00:18:26,840 --> 00:18:31,120
+shall, or will, plus the stem of the verb. Okay.
+
+190
+00:18:31,120 --> 00:18:37,080
+Semantically, it expresses willingness, offer
+
+191
+00:18:37,080 --> 00:18:45,900
+request, threat, determination, I promise. Okay? We
+
+192
+00:18:45,900 --> 00:18:50,140
+have this in Arabic. So, both languages are
+
+193
+00:18:50,140 --> 00:18:53,080
+identical semantically in using the future simple,
+
+194
+00:18:53,460 --> 00:18:56,860
+but they differ syntactically. In Arabic, we use
+
+195
+00:18:56,860 -->
+
+223
+00:21:27,230 --> 00:21:33,710
+progress at a certain time in future. shall will
+
+224
+00:21:33,710 --> 00:21:39,550
+plus the progressive construction of the verb, the
+
+225
+00:21:39,550 --> 00:21:46,850
+aspect, verb to be plus verb plus ing we shall be
+
+226
+00:21:46,850 --> 00:21:52,670
+traveling shall will plus be plus verb plus ing
+
+227
+00:22:03,440 --> 00:22:09,980
+Also, the future progressive shall, will be, their
+
+228
+00:22:09,980 --> 00:22:13,340
+plus ing construction is also used to avoid the
+
+229
+00:22:13,340 --> 00:22:18,560
+interpretation of volition, insistence, etc. That
+
+230
+00:22:18,560 --> 00:22:22,260
+future simple is characterized with, I'll do my
+
+231
+00:22:22,260 --> 00:22:27,340
+best. I'll be doing my best. What's the difference
+
+232
+00:22:27,340 --> 00:22:31,400
+between the two Sentences who could you translate
+
+233
+00:22:31,400 --> 00:22:34,840
+these two sentences? I'll do my best. I'll be
+
+234
+00:22:34,840 --> 00:22:39,100
+doing my best Okay
+
+235
+00:22:39,100 --> 00:22:45,460
+Yes,
+
+236
+00:22:45,740 --> 00:22:51,400
+mm-hmm hooker translated yes, I'll do my best I
+
+237
+00:22:57,400 --> 00:23:00,620
+This is a promise to do my best. Okay, it is
+
+238
+00:23:00,620 --> 00:23:03,260
+promise. طيب I'll be doing my best.
+
+239
+00:23:06,740 --> 00:23:10,480
+This is
+
+240
+00:23:10,480 --> 00:23:15,620
+determination. I'll be doing my best. Okay, I'll
+
+241
+00:23:15,620 --> 00:23:19,860
+be doing my best. This is determination. يعني
+
+242
+00:23:19,860 --> 00:23:26,710
+الأولى I'll do my best سأفعل الأفضل and the second
+
+243
+00:23:26,710 --> 00:23:40,270
+انا مصمم على فعل الأفضل او عازم على فعل الأفضل سوف
+
+244
+00:23:40,270 --> 00:23:48,850
+أبذل قصارى جهدي okay الأولى
+
+245
+00:23:48,850 --> 00:23:53,330
+you have to use سوف سوف أبذل قصارى جهدي في مساعدتك
+
+246
+00:23:53,880 --> 00:23:59,820
+ثانية سأبذل قصارى جهدي okay س refers to the near
+
+247
+00:23:59,820 --> 00:24:06,820
+future okay once you express progressive use س or
+
+248
+00:24:06,820 --> 00:24:17,140
+any near future طيب
+
+249
+00:24:19,080 --> 00:24:22,540
+Now standard Arabic, do we have future continuous
+
+250
+00:24:22,540 --> 00:24:24,400
+or progressive in Arabic or not?
+
+251
+00:24:28,500 --> 00:24:34,800
+سيلعب فريقنا الكورة سيلعب
+
+252
+00:24:34,800 --> 00:24:41,180
+فريقنا الكورة عند الساعة السابعة مساء يعني at
+
+253
+00:24:41,180 --> 00:24:45,420
+seven o'clock our team will be playing football
+
+254
+00:24:46,330 --> 00:24:51,310
+Okay, we have this سيلعب فريقنا الكورة عند الساعة
+
+255
+00:24:51,310 --> 00:24:55,750
+السابعة مساء So this construction and the future
+
+256
+00:24:55,750 --> 00:25:03,550
+progressive in Arabic consists of what? Okay It
+
+257
+00:25:03,550 --> 00:25:09,930
+is س plus imperfect indicative form سيلعب Okay,
+
+258
+00:25:10,470 --> 00:25:12,290
+followed by a point of time
+
+259
+00:25:17,700 --> 00:25:21,940
+Okay, followed by a point of time. سيلعب فريقنا
+
+260
+00:25:21,940 --> 00:25:25,480
+الكورة. So we have س plus the imperfect indicative
+
+261
+00:25:25,480 --> 00:25:33,280
+form of the verb plus the noun followed by a point
+
+262
+00:25:33,280 --> 00:25:33,780
+of time.
+
+263
+00:25:42,840 --> 00:25:49,190
+سيلعب فريقنا الكورة عند الساعة السابعة مساء. Okay?
+
+264
+00:25:49,970 --> 00:25:52,910
+Our team will be playing football at seven o'clock
+
+265
+00:25:52,910 --> 00:25:53,850
+tomorrow.
+
+266
+00:25:57,670 --> 00:26:03,310
+Now we come to future perfect. Future perfect in
+
+267
+00:26:03,310 --> 00:26:09,890
+English refers to an action that will finish at a
+
+268
+00:26:09,890 --> 00:26:15,330
+future time at a specific future time in English.
+
+269
+00:26:16,800 --> 00:26:22,380
+I say the government or the company will have the
+
+270
+00:26:22,380 --> 00:26:27,420
+project built, will have the project built or will
+
+271
+00:26:27,420 --> 00:26:33,380
+finish the project by the end of next April. The
+
+272
+00:26:33,380 --> 00:26:38,280
+company will have the project, will have finished
+
+273
+00:26:38,280 --> 00:26:43,440
+the project by
+
+274
+00:26:43,440 --> 00:26:49,930
+next April. Okay, or by the end of next April will
+
+275
+00:26:49,930 --> 00:26:55,430
+have finished Well, what do you call well? Tense
+
+276
+00:26:55,430 --> 00:27:03,370
+have Simple aspect finished Perfect
+
+277
+00:27:04,440 --> 00:27:09,560
+perfect or perfective aspect so the future perfect
+
+278
+00:27:09,560 --> 00:27:14,020
+consists of tense plus simple aspect and
+
+279
+00:27:14,020 --> 00:27:16,580
+perfective aspect okay
+
+280
+00:27:26,910 --> 00:27:30,190
+refers to an action that will have happened before
+
+281
+00:27:30,190 --> 00:27:33,450
+some other future action happened or before some
+
+282
+00:27:33,450 --> 00:27:38,790
+point of time arrives. They shall have played two
+
+283
+00:27:38,790 --> 00:27:42,150
+games of tennis before we arrive there.
+
+284
+00:27:45,330 --> 00:27:48,830
+Before we arrive, they will have finished two
+
+285
+00:27:48,830 --> 00:27:54,690
+games or two rounds of tennis. They shall have
+
+286
+00:27:54,690 --> 00:27:58,390
+played two games of tennis before we arrive there.
+
+287
+00:27:59,130 --> 00:28:04,130
+So the first verb is future perfect. The second is
+
+288
+00:28:04,130 --> 00:28:09,090
+future simple, okay, which refers to future. They
+
+289
+00:28:09,090 --> 00:28:11,970
+will have graduated by the end of April. They will
+
+290
+00:28:11,970 --> 00:28:16,070
+have graduated. So it refers to an action that
+
+291
+00:28:16,070 --> 00:28:21,750
+will be completed at a certain time in future. The
+
+292
+00:28:21,750 --> 00:28:25,870
+action may be in progress now. It started in the
+
+293
+00:28:25,870 --> 00:28:30,090
+past, still in progress, and will finish at a
+
+294
+00:28:30,090 --> 00:28:36,230
+specific time in future. We are present perfect
+
+295
+00:28:36,230 --> 00:28:40,850
+continuous. When I say I have been studying
+
+296
+00:28:40,850 --> 00:28:45,550
+English for 10 years, Okay, this is different.
+
+297
+00:28:46,270 --> 00:28:49,310
+Okay, it refers to an action that started in the
+
+298
+00:28:49,310 --> 00:28:55,230
+past is progressive now and will finish at unknown
+
+299
+00:28:55,230 --> 00:28:59,470
+time, not specific time. Okay.
+
+300
+00:29:03,730 --> 00:29:06,690
+Now, do we have the same equivalent in Arabic? Do
+
+301
+00:29:06,690 --> 00:29:10,350
+we have future perfect in Arabic or not? Yes, we
+
+302
+00:29:10,350 --> 00:29:10,670
+have.
+
+303
+00:29:43,010 --> 00:29:46,710
+They will have finished the project by next March.
+
+304
+00:29:48,900 --> 00:29:53,680
+okay? سَيَكُنُوا قَدْ أَنْهُ So we have the
+
+305
+00:29:53,680 --> 00:30:00,900
+construction سَ which refers to near future يَكُن
+
+306
+00:30:00,900 --> 00:30:09,460
+this is the indicative this is the imperfect verb
+
+307
+00:30:09,460 --> 00:30:16,920
+the defective verb from كان يكون plus the
+
+308
+00:30:16,920 --> 00:30:23,810
+expletive قَدْ and the perfect form of the verb
+
+309
+00:30:23,810 --> 00:30:27,790
+أنها سيكونوا
+
+310
+00:30:27,790 --> 00:30:36,170
+قد أنهوا العمل في المشروع في مارس القادم okay so
+
+311
+00:30:36,170 --> 00:30:42,590
+we have the future particle س plus the defective
+
+312
+00:30:42,590 --> 00:30:46,250
+verb in the imperfect indicative form يكون present
+
+313
+00:30:46,250 --> 00:30:51,350
+form followed by the expletive قد and the past
+
+314
+00:30:51,350 --> 00:30:55,650
+form of the verb this semantically expresses
+
+315
+00:30:55,650 --> 00:30:59,950
+future perfect in Arabic so it is expressed
+
+316
+00:30:59,950 --> 00:31:04,130
+lexically however in English it is expressed
+
+317
+00:31:04,130 --> 00:31:11,710
+grammatically or syntactically okay سيكون قد أنهى
+
+318
+00:31:11,710 --> 00:31:21,310
+سيكون زيد قد أنهى العمل في المشروع في بداية مارس
+
+319
+00:31:21,310 --> 00:31:26,310
+القادر. So this is called future perfect in
+
+320
+00:31:26,310 --> 00:31:29,150
+Arabic. Okay.
+
+321
+00:31:34,230 --> 00:31:38,010
+They will have finished the project by the
+
+322
+00:31:38,010 --> 00:31:42,890
+beginning of March. Okay. Yes.
+
+323
+00:31:49,420 --> 00:31:55,780
+No, no, here we have, we don't have will and shall
+
+324
+00:31:55,780 --> 00:32:00,040
+translation into Arabic. Both are sawfa or sah.
+
+325
+00:32:00,580 --> 00:32:02,780
+However, once you translate the sentence into
+
+326
+00:32:02,780 --> 00:32:06,450
+English, you have to consider the translation
+
+327
+00:32:06,450 --> 00:32:11,370
+shell with the first person i we however well with
+
+328
+00:32:11,370 --> 00:32:14,710
+the rest of the pronouns in case of future simple
+
+329
+00:32:14,710 --> 00:32:18,970
+a future continuous future perfect future perfect
+
+330
+00:32:18,970 --> 00:32:22,690
+continuous etc you have these limitations in
+
+331
+00:32:22,690 --> 00:32:25,910
+translation for shell or well just in the use of
+
+332
+00:32:25,910 --> 00:32:30,950
+future simple Once you express willingness, once
+
+333
+00:32:30,950 --> 00:32:34,750
+you express promise, once you express offer, once
+
+334
+00:32:34,750 --> 00:32:39,630
+you express threat, determination, or request. So
+
+335
+00:32:39,630 --> 00:32:44,650
+you have specific translation
+
+336
+00:32:44,650 --> 00:32:48,330
+for shell or will. So you have to take care of
+
+337
+00:32:48,330 --> 00:32:50,410
+that. However, in the rest of the future
+
+338
+00:32:50,410 --> 00:32:53,030
+constructions, you have the form which you are
+
+339
+00:32:53,030 --> 00:32:56,930
+familiar with. shall with the first person and
+
+340
+00:32:56,930 --> 00:32:59,670
+will with the rest of the pronouns.
+
+341
+00:33:03,090 --> 00:33:06,390
+They will have finished building the house by next
+
+342
+00:33:06,390 --> 00:33:14,430
+May. This is
+
+343
+00:33:14,430 --> 00:33:15,370
+future perfect.
+
+344
+00:33:21,370 --> 00:33:27,950
+So we have two constructions. س ينهوا plus the
+
+345
+00:33:27,950 --> 00:33:34,790
+derived nominal بناء or س يكونون قد أنهوا س plus
+
+346
+00:33:34,790 --> 00:33:40,190
+the defective verb يكون plus the expletive قد plus
+
+347
+00:33:40,190 --> 00:33:43,310
+the imperfect indicative form of the verb the
+
+348
+00:33:43,310 --> 00:33:46,630
+perfect indicative form perfect indicative form
+
+349
+00:33:46,630 --> 00:33:52,630
+يعني الماضي من الفعل ينهي أنها okay finish
+
+350
+00:33:52,630 --> 00:33:53,150
+finished
+
+351
+00:33:58,330 --> 00:34:01,470
+Now we have future perfect continuous.
+
+352
+00:34:04,930 --> 00:34:09,550
+In English, this construction refers to an action
+
+353
+00:34:09,550 --> 00:34:15,130
+that will be in progress after a certain time in
+
+354
+00:34:15,130 --> 00:34:19,980
+future. It expresses an action that will be in
+
+355
+00:34:19,980 --> 00:34:24,380
+progress when some point of time arrives. In 2009,
+
+356
+00:34:25,240 --> 00:34:30,600
+I say here, in 2014, for example, in 2014, I shall
+
+357
+00:34:30,600 --> 00:34:36,020
+have been teaching English for 20 years. In 2014,
+
+358
+00:34:37,360 --> 00:34:39,280
+in 2014,
+
+359
+00:34:41,200 --> 00:34:44,820
+I shall have been teaching English for 20 years.
+
+360
+00:34:54,780 --> 00:35:01,620
+in 2014 I shall be teaching English for 20 years
+
+361
+00:35:01,620 --> 00:35:08,420
+this means that here we use future perfect future
+
+362
+00:35:08,420 --> 00:35:14,860
+future perfect continuous in 2014 I'll have been
+
+363
+00:35:14,860 --> 00:35:18,920
+teaching English for 20 years this means that I'm
+
+364
+00:35:18,920 --> 00:35:25,530
+going to resign in 2014 No, the action will be in
+
+365
+00:35:25,530 --> 00:35:29,710
+progress. Okay? So it refers to an action that
+
+366
+00:35:29,710 --> 00:35:33,670
+will be continuous after a certain time in future.
+
+367
+00:35:39,890 --> 00:35:40,810
+You see?
+
+368
+00:36:17,880 --> 00:36:22,640
+Okay Future Perfect
+
+369
+00:36:22,640 --> 00:36:29,960
+continuous, okay Do
+
+370
+00:36:29,960 --> 00:36:33,860
+we have future perfect continuous in Arabic? Yes,
+
+371
+00:36:33,880 --> 00:36:45,090
+we have سيكونوا قد ناموا ساعتين عند الخامسة مساء
+
+372
+00:36:45,090 --> 00:36:48,910
+سيكونوا
+
+373
+00:36:48,910 --> 00:36:53,210
+الأطفال قد ناموا ساعتين عند الخامسة مساء يعني once
+
+374
+00:36:53,210 --> 00:36:56,310
+you come to the house you'll find the kids
+
+375
+00:36:56,310 --> 00:37:00,370
+sleeping for two hours and they remain or they
+
+376
+00:37:00,370 --> 00:37:06,170
+still sleep okay so the action is in progress at a
+
+377
+00:37:06,170 --> 00:37:11,230
+certain time in future they will have been
+
+378
+00:37:11,230 --> 00:37:14,650
+sleeping for two hours by five o'clock in the
+
+379
+00:37:14,650 --> 00:37:23,730
+evening okay so we have the verb we have the
+
+380
+00:37:23,730 --> 00:37:28,400
+construction plus the defective verb in the
+
+381
+00:37:28,400 --> 00:37:31,840
+imperfect form in the imperfect indicative form
+
+382
+00:37:31,840 --> 00:37:38,960
+يكون plus the expletive قد plus the perfect form
+
+383
+00:37:38,960 --> 00:37:48,640
+of the verb نام okay سيكونوا قد ناموا ساعتين عند
+
+384
+00:37:48,640 --> 00:37:52,360
+الخمسة مساء plus طبعا a point of time
+
+385
+00:37:55,740 --> 00:37:58,740
+They will have been sleeping for two hours by five
+
+386
+00:37:58,740 --> 00:38:04,040
+o'clock in the evening. Now we have also the
+
+387
+00:38:04,040 --> 00:38:07,160
+future construction expressed by future by simple
+
+388
+00:38:07,160 --> 00:38:14,200
+present in English. I say for example, let's wait
+
+389
+00:38:14,200 --> 00:38:15,320
+until he comes.
+
+390
+00:38:18,400 --> 00:38:22,980
+So we have the present simple denoting future in
+
+391
+00:38:22,980 --> 00:38:28,990
+clauses of time and condition. Okay, I say for
+
+392
+00:38:28,990 --> 00:38:33,110
+example, let's wait until he comes. What will you
+
+393
+00:38:33,110 --> 00:38:38,610
+say if I punish him? Punish. What does this refer
+
+394
+00:38:38,610 --> 00:38:42,110
+to? Does it refer to present action or to future
+
+395
+00:38:42,110 --> 00:38:46,050
+action? Future action expressed by the present
+
+396
+00:38:46,050 --> 00:38:52,150
+simple. So the tense here present tense here
+
+397
+00:38:52,150 --> 00:38:57,980
+expresses future event That is part of settled
+
+398
+00:38:57,980 --> 00:39:05,360
+program. He leaves for Egypt tomorrow. Leaves. It
+
+399
+00:39:05,360 --> 00:39:11,200
+refers to near future. Near programmed action. She
+
+400
+00:39:11,200 --> 00:39:13,960
+arrives by 10 o'clock train this evening.
+
+401
+00:39:14,960 --> 00:39:18,440
+Programmed action. We speak about the railway
+
+402
+00:39:18,440 --> 00:39:22,990
+train. which is of computer system it is
+
+403
+00:39:22,990 --> 00:39:28,290
+computerized system okay so she arrives by 10 o
+
+404
+00:39:28,290 --> 00:39:31,170
+'clock this means that she will arrive exactly on
+
+405
+00:39:31,170 --> 00:39:36,110
+time at 10 o'clock okay since we have timetable or
+
+406
+00:39:36,110 --> 00:39:40,190
+programmed action then we use present simple okay
+
+407
+00:39:40,190 --> 00:39:45,390
+it is used also for formal or official actions.
+
+408
+00:39:46,070 --> 00:39:50,290
+The president travels to Egypt by the 10 o'clock
+
+409
+00:39:50,290 --> 00:39:56,390
+flight tonight. The president travels. If you
+
+410
+00:39:56,390 --> 00:40:00,750
+speak about any personality, official personality,
+
+411
+00:40:01,270 --> 00:40:06,350
+if official personnel, then you use present simple
+
+412
+00:40:06,350 --> 00:40:10,270
+to refer to future action. However, if you speak
+
+413
+00:40:10,270 --> 00:40:13,330
+about ordinary people, we use present continuous.
+
+414
+00:40:14,330 --> 00:40:19,950
+Okay. So I am traveling to Egypt by the 10 o'clock
+
+415
+00:40:19,950 --> 00:40:25,350
+flight. I'm traveling. I am ordinary man. However,
+
+416
+00:40:25,490 --> 00:40:29,850
+the president travels to Egypt. You understand
+
+417
+00:40:29,850 --> 00:40:34,090
+that? Did you get that? Okay. The president
+
+418
+
+445
+00:43:13,520 --> 00:43:17,340
+We 
+
+446
+00:43:17,340 --> 00:43:28,040
+have this also in Arabic, the 
+
+447
+00:43:28,040 --> 00:43:34,720
+present progressive in Arabic is expressed by the
+
+448
+00:43:34,720 --> 00:43:38,200
+nominal subject, اسم الفاعل قادم
+
+449
+00:43:40,430 --> 00:43:44,790
+In Arabic? Yes. So derived subject, sorry, nominal
+
+450
+00:43:44,790 --> 00:43:48,930
+subject. When I say derived subject, this is the 
+
+451
+00:43:48,930 --> 00:43:51,690
+noun of the verb. This is the noun of the verb.
+
+452
+00:43:53,670 --> 00:43:59,750
+Nominal subject. I am coming to visit you today. I
+
+453
+00:43:59,750 --> 00:44:02,770
+am coming. This is present progressive referring 
+
+454
+00:44:02,770 --> 00:44:07,450
+to an action that will happen at a planned time
+
+455
+00:44:08,630 --> 00:44:14,750
+okay, in the near future, okay
+
+456
+00:44:14,750 --> 00:44:21,250
+We 
+
+457
+00:44:21,250 --> 00:44:27,950
+also have other constructions. We 
+
+458
+00:44:27,950 --> 00:44:31,130
+have other constructions in English that refer to 
+
+459
+00:44:31,130 --> 00:44:39,930
+future like going to, be to, about to, okay going to, 
+
+460
+00:44:40,750 --> 00:44:45,510
+be to, about to. These also express future in 
+
+461
+00:44:45,510 --> 00:44:49,390
+English. Once we say going to, this refers to
+
+462
+00:44:49,390 --> 00:44:56,370
+cause or intention. Okay? Now, I'm going to 
+
+463
+00:44:56,370 --> 00:45:01,420
+graduate by the end of this semester. This means
+
+464
+00:45:01,420 --> 00:45:05,820
+that you studied for four years and you are going 
+
+465
+00:45:05,820 --> 00:45:09,120
+to have your BBA by the end of this semester. You
+
+466
+00:45:09,120 --> 00:45:12,740
+are going to graduate. So you have the complete 
+
+467
+00:45:12,740 --> 00:45:20,780
+cause for the action. Okay? Mariam is pregnant. 
+
+468
+00:45:21,680 --> 00:45:28,220
+She's going to have a baby next month. Okay? She's 
+
+469
+00:45:28,220 --> 00:45:32,380
+pregnant. It's the cause for the action which 
+
+470
+00:45:32,380 --> 00:45:40,460
+happens next month. The delivery. Maryam is going 
+
+471
+00:45:40,460 --> 00:45:44,400
+to have a baby next month. Going to, we have 
+
+472
+00:45:44,400 --> 00:45:49,240
+cause. We have also intention. I'm going to attend 
+
+473
+00:45:49,240 --> 00:45:53,560
+Ahmed's party tonight. I have the intention, the 
+
+474
+00:45:53,560 --> 00:45:58,340
+intention to attend the party. So I use going to. 
+
+475
+00:45:59,180 --> 00:46:02,440
+Do you have this in Arabic? Do you have equivalent
+
+476
+00:46:02,440 --> 00:46:07,200
+for be to or about to in Arabic? This is what we are
+
+477
+00:46:07,200 --> 00:46:11,520
+going to see next time. Okay, that's it for today. 
+
+478
+00:46:11,640 --> 00:46:12,100
+Thank you. 
diff --git a/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/CwFequR3Y5g.srt b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/CwFequR3Y5g.srt
new file mode 100644
index 0000000000000000000000000000000000000000..c8a0bc28e841716ec4dc5d0394ef783da3c3a091
--- /dev/null
+++ b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/CwFequR3Y5g.srt
@@ -0,0 +1,1650 @@
+
+1
+00:00:00,000 --> 00:00:00,800
+You.
+
+2
+00:00:34,780 --> 00:00:38,200
+Bismillah ar-Rahman ar-Rahim. Today we are going
+
+3
+00:00:38,200 --> 00:00:42,360
+to continue with infinitive and gerund in English
+
+4
+00:00:42,360 --> 00:00:47,800
+versus overt and covert derived nominal in Arabic.
+
+5
+00:00:52,260 --> 00:00:55,860
+Last time we saw the function, we've seen the
+
+6
+00:00:55,860 --> 00:00:59,820
+function of the syntactic function of infinitive
+
+7
+00:00:59,820 --> 00:01:03,120
+in English. We mentioned that the syntactic
+
+8
+00:01:03,120 --> 00:01:09,390
+function covers four points. The infinitive can be
+
+9
+00:01:09,390 --> 00:01:10,510
+a subject.
+
+10
+00:01:13,950 --> 00:01:19,710
+Yes. Can stand as a subject, as object, as subject
+
+11
+00:01:19,710 --> 00:01:25,710
+complement, and object complement. Okay? This is
+
+12
+00:01:25,710 --> 00:01:30,870
+in English. It is also the same in Arabic. We have
+
+13
+00:01:30,870 --> 00:01:36,370
+the derived nominal, derived nominal stands as a
+
+14
+00:01:36,370 --> 00:01:41,610
+subject, as object, as subject complement, or
+
+15
+00:01:41,610 --> 00:01:42,490
+object complement.
+
+16
+00:01:53,450 --> 00:01:56,690
+Then we shifted to what is called sensation verbs.
+
+17
+00:01:58,510 --> 00:02:03,160
+We've seen that the sensation verbs like see, hear,
+
+18
+00:02:03,900 --> 00:02:12,620
+touch, notice. Look, these only accept bare
+
+19
+00:02:12,620 --> 00:02:16,720
+infinitive. Bare infinitive. Yani infinitive
+
+20
+00:02:16,720 --> 00:02:20,500
+without to. Okay? I heard them talk about the
+
+21
+00:02:20,500 --> 00:02:25,340
+plan. I heard them talk about the plan. I saw Ali
+
+22
+00:02:25,340 --> 00:02:29,420
+stand at the gate. I noticed her pick a flower.
+
+23
+00:02:30,380 --> 00:02:34,970
+Okay? However, in Arabic, we don't have bare
+
+24
+00:02:34,970 --> 00:02:41,030
+infinitive. We have the present imperfect
+
+25
+00:02:41,030 --> 00:02:44,990
+indicative form of the verb. This means that the
+
+26
+00:02:44,990 --> 00:02:49,030
+verb stands with inflections. We have persons
+
+27
+00:02:49,030 --> 00:02:54,330
+added to the verb. Samaatuhu yatakellamu 3an
+
+28
+00:02:54,330 --> 00:02:59,730
+alkhatta. Samaatuhu yatakellam. Okay, so
+
+29
+00:02:59,730 --> 00:03:04,500
+yatakellam, this is present. Verb present in
+
+30
+00:03:04,500 --> 00:03:10,300
+perfect indicative form. Yeah this is third person
+
+31
+00:03:10,300 --> 00:03:18,720
+inflection in Arabic يتكلم تكلم أتكلم sorry يتكلم
+
+32
+00:03:18,720 --> 00:03:22,880
+أتكلم نتكلم تتكلم so we have four inflections
+
+33
+00:03:22,880 --> 00:03:27,930
+representing persons in Arabic okay it's different
+
+34
+00:03:27,930 --> 00:03:31,810
+from English which has only one inflection that is
+
+35
+00:03:31,810 --> 00:03:39,870
+the subject verb agreement us okay
+
+36
+00:03:39,870 --> 00:03:44,530
+still we have three verbs in English which are
+
+37
+00:03:44,530 --> 00:03:50,090
+related to sensation verbs these are like help let
+
+38
+00:03:50,090 --> 00:03:56,180
+and and make yes let help and make these accept
+
+39
+00:03:56,180 --> 00:04:03,860
+both their infinitive and to infinitive now this
+
+40
+00:04:03,860 --> 00:04:07,380
+cannot be corresponded to Arabic since Arabic has
+
+41
+00:04:07,380 --> 00:04:12,640
+the inflections added to the verb okay دعه يتكلم
+
+42
+00:04:12,640 --> 00:04:13,460
+عن الخطة
+
+43
+00:04:18,340 --> 00:04:25,160
+present in perfect indicative form of the verb now
+
+44
+00:04:25,160 --> 00:04:30,340
+we have a problem with infinitives and gerunds
+
+45
+00:04:30,340 --> 00:04:33,760
+verbs which accept infinitives infinitive or
+
+46
+00:04:33,760 --> 00:04:40,040
+gerund we just have
+
+47
+00:04:40,040 --> 00:04:44,370
+this point Very tricky just for it appears very
+
+48
+00:04:44,370 --> 00:04:48,970
+tricky for our students since they confuse just in
+
+49
+00:04:48,970 --> 00:04:52,630
+using either infinitive or gerund. So they commit
+
+50
+00:04:52,630 --> 00:04:57,050
+serious mistakes in this side. Most of them are
+
+51
+00:04:57,050 --> 00:05:02,090
+interlingual or interlingual? Interlingual. These
+
+52
+00:05:02,090 --> 00:05:05,230
+are interlingual. Interlingual.
+
+53
+00:05:14,340 --> 00:05:20,440
+Most of them are intralingual. So we try to solve
+
+54
+00:05:20,440 --> 00:05:29,250
+this problem by having a new account. a theory
+
+55
+00:05:29,250 --> 00:05:33,750
+that accounts for the use of infinitive or gerund.
+
+56
+00:05:34,330 --> 00:05:37,250
+But before introducing this theory, we need to
+
+57
+00:05:37,250 --> 00:05:40,770
+introduce the previous theories in this or the
+
+58
+00:05:40,770 --> 00:05:44,030
+previous principles in this regard. We have
+
+59
+00:05:44,030 --> 00:05:50,350
+Bollinger's principle, okay, in which the choice
+
+60
+00:05:50,350 --> 00:05:53,750
+of infinitive correlates in some degree with
+
+61
+00:05:53,750 --> 00:05:58,160
+events that are theoretical or hypothetical. Okay,
+
+62
+00:05:58,580 --> 00:06:02,680
+or hypothetical, all hypothetical actions are in,
+
+63
+00:06:03,620 --> 00:06:08,320
+they take infinitive. However, the vivid or actual
+
+64
+00:06:08,320 --> 00:06:14,760
+or already fulfilled actions are gerund. Okay, so
+
+65
+00:06:14,760 --> 00:06:18,460
+speak about real actions that take gerund. We have
+
+66
+00:06:18,460 --> 00:06:23,080
+hypothetical actions which only take infinitive.
+
+67
+00:06:23,500 --> 00:06:26,620
+Speak about things which will happen. This is
+
+68
+00:06:26,620 --> 00:06:30,940
+infinitive. Things which have already happened or
+
+69
+00:06:30,940 --> 00:06:36,020
+are in progress, they take gerund as well. Okay?
+
+70
+00:06:36,500 --> 00:06:39,800
+But applying this principle on the verb, for
+
+71
+00:06:39,800 --> 00:06:44,700
+example, start, comes out with negative results.
+
+72
+00:06:45,840 --> 00:06:49,360
+It stands to rain. Sorry, it's start. It starts to
+
+73
+00:06:49,360 --> 00:06:53,240
+rain. It starts raining. Is there any difference
+
+74
+00:06:53,240 --> 00:06:57,450
+in translation? There's no difference. Okay?
+
+75
+00:06:57,570 --> 00:07:01,190
+There's no difference. Richard continued to work.
+
+76
+00:07:01,690 --> 00:07:06,050
+Richard continued working. Okay? We don't have
+
+77
+00:07:06,050 --> 00:07:10,010
+dissimilarities or any difference just in
+
+78
+00:07:10,010 --> 00:07:13,210
+translating these two sentences. I prefer to eat
+
+79
+00:07:13,210 --> 00:07:18,730
+sandwiches. I prefer eating sandwiches. So, these
+
+80
+00:07:18,730 --> 00:07:22,890
+verbs start, prefer, continue
+
+81
+00:07:25,720 --> 00:07:32,440
+cannot accept Bollinger's principle. This
+
+82
+00:07:32,440 --> 00:07:37,960
+necessitates thinking of a new principle that can
+
+83
+00:07:37,960 --> 00:07:42,020
+be applied on all the verbs of English which
+
+84
+00:07:42,020 --> 00:07:46,780
+accept either infinitive or gerund or both we are
+
+85
+00:07:46,780 --> 00:07:49,820
+in front of some verbs which accept both the
+
+86
+00:07:49,820 --> 00:07:53,640
+alternate between infinitive and gerund and some
+
+87
+00:07:53,640 --> 00:07:58,780
+other verbs only accept gerund we have verbs only
+
+88
+00:07:58,780 --> 00:08:02,840
+accept infinitive so
+
+89
+00:08:05,510 --> 00:08:12,910
+I came with a new account which divides the verbs
+
+90
+00:08:12,910 --> 00:08:17,510
+accepting infinitive and gerund or either one of
+
+91
+00:08:17,510 --> 00:08:22,910
+them. I divided them into four categories. Okay.
+
+92
+00:08:23,310 --> 00:08:29,110
+First of all, the emotive verbs, aspectual verbs,
+
+93
+00:08:30,450 --> 00:08:35,480
+reactive verbs and forward oriented verbs. Okay?
+
+94
+00:08:36,040 --> 00:08:41,960
+So for emotive verbs, these
+
+95
+00:08:41,960 --> 00:08:50,600
+verbs are not associated with time. Okay? They are
+
+96
+00:08:50,600 --> 00:08:55,320
+like dread, hate, like, love, lose, prefer, and
+
+97
+00:08:55,320 --> 00:09:01,040
+rejoice. These verbs are not connected to time.
+
+98
+00:09:01,680 --> 00:09:07,810
+Okay? So they accept both infinitive and gerund. I
+
+99
+00:09:07,810 --> 00:09:11,290
+hated to meet the boss. I hated meeting the boss.
+
+100
+00:09:12,390 --> 00:09:16,690
+We have difference in translation here. The first
+
+101
+00:09:16,690 --> 00:09:21,150
+sentence refers to an action that has not
+
+102
+00:09:21,150 --> 00:09:26,010
+happened. Okay? Future action. Okay? The second
+
+103
+00:09:26,010 --> 00:09:30,330
+one refers to an action which happened. Okay?
+
+104
+00:09:32,840 --> 00:09:35,460
+Would you like to see my dad? Would you like
+
+105
+00:09:35,460 --> 00:09:36,260
+seeing my dad?
+
+106
+00:09:39,600 --> 00:09:43,280
+Here we have also some sort of difference between
+
+107
+00:09:43,280 --> 00:09:46,760
+the two sentences. The first one, the verb see,
+
+108
+00:09:47,300 --> 00:09:51,660
+refers to, I mean, the infinitive to see refers to
+
+109
+00:09:51,660 --> 00:09:56,280
+future action, hypothetical action. However, the
+
+110
+00:09:56,280 --> 00:10:02,960
+second one refers to real action, okay? Do you
+
+111
+00:10:02,960 --> 00:10:07,100
+prefer to read the daily or watch the TV? Or to
+
+112
+00:10:07,100 --> 00:10:10,480
+watch the TV? Do you prefer reading the daily or
+
+113
+00:10:10,480 --> 00:10:14,060
+watching the TV? Again, the first sentence is
+
+114
+00:10:14,060 --> 00:10:17,160
+hypothetical. It is theoretical, refers to an
+
+115
+00:10:17,160 --> 00:10:20,800
+action that is to happen. However, the second one
+
+116
+00:10:20,800 --> 00:10:25,280
+refers to a habit which actually happens every
+
+117
+00:10:25,280 --> 00:10:28,360
+day. I mean action which already happened. We
+
+118
+00:10:28,360 --> 00:10:31,180
+speak about vivid or real action which is
+
+119
+00:10:31,180 --> 00:10:31,700
+fulfilled.
+
+120
+00:10:37,380 --> 00:10:40,780
+Do we have emotive verbs in Arabic? What about
+
+121
+00:10:40,780 --> 00:10:45,120
+their structure? Yes, we have emotive verbs in
+
+122
+00:10:45,120 --> 00:11:00,440
+Arabic like يفضل يخاف يبغض يكره يحب يخشى يعجب يعشق
+
+123
+00:11:00,440 --> 00:11:06,380
+etc These are emotive verbs They touch the feeling
+
+124
+00:11:08,060 --> 00:11:13,920
+They are not related to time influence. Okay? We
+
+125
+00:11:13,920 --> 00:11:20,680
+have يحب زيد قراءة القرآن. يحب زيد أن يقرأ القرآن.
+
+126
+00:11:21,360 --> 00:11:25,100
+So they accept both. So the emotive verbs of
+
+127
+00:11:25,100 --> 00:11:28,300
+Arabic are the same like the emotive verbs of
+
+128
+00:11:28,300 --> 00:11:28,700
+English.
+
+129
+00:11:36,040 --> 00:11:44,460
+Yes. We have يكره الولد اللعب في الشارع يكره الولد
+
+130
+00:11:44,460 --> 00:11:49,900
+اللعب في الشارع So we have the first sentence it
+
+131
+00:11:49,900 --> 00:11:53,840
+is of overt derived nominal while the second one
+
+132
+00:11:53,840 --> 00:12:02,620
+is of a modified derived nominal يفضل
+
+133
+00:12:02,620 --> 00:12:07,380
+زيدن شرب الشاي Overt, derived nominal, as you see.
+
+134
+00:12:07,720 --> 00:12:09,860
+يفضل زيد أن يشرب الشاي.
+
+135
+00:12:14,740 --> 00:12:20,620
+يخاف المؤمن ارتكاب الكبار. يخاف المؤمن أن يرتكب
+
+136
+00:12:20,620 --> 00:12:24,840
+الكبار. So we have overt derived nominal and
+
+137
+00:12:24,840 --> 00:12:27,760
+covert derived nominal within the same time. So
+
+138
+00:12:27,760 --> 00:12:31,540
+this, I mean the emotive verbs, the emotive verbs
+
+139
+00:12:33,380 --> 00:12:37,360
+are alternating between infinitive and gerund.
+
+140
+00:12:39,720 --> 00:12:41,940
+What about aspectual verbs?
+
+141
+00:12:45,200 --> 00:12:52,380
+They are associated with time. Yes. The aspectual
+
+142
+00:12:52,380 --> 00:12:55,620
+verbs are associated to time. They refer to a
+
+143
+00:12:55,620 --> 00:13:02,670
+variety of time. Okay? So these refer to a variety
+
+144
+00:13:02,670 --> 00:13:08,910
+of time aspects like initiation, continuation,
+
+145
+00:13:09,670 --> 00:13:14,090
+repetition, termination. So we have verbs like
+
+146
+00:13:14,090 --> 00:13:16,650
+begin.
+
+147
+00:13:17,150 --> 00:13:20,730
+This is initiation. Resume.
+
+148
+00:13:23,870 --> 00:13:27,870
+Resume. This is repetition. Okay.
+
+149
+00:13:34,950 --> 00:13:40,690
+It is more related to repetition. You repeat the
+
+150
+00:13:40,690 --> 00:13:48,830
+action. Okay? Remain. Continuation. Commence.
+
+151
+00:13:50,030 --> 00:13:55,570
+Initiation. Finish. Continue. Discontinue.
+
+152
+00:13:59,630 --> 00:14:11,050
+Termination. End up. Seize. Repeat. Complete. Give
+
+153
+00:14:11,050 --> 00:14:20,290
+up. Postpone. Proceed. Continuation. Quit. Keep.
+
+154
+00:14:20,550 --> 00:14:27,610
+Keep on. Start. Initiation. Stay. Continuation.
+
+155
+00:14:27,690 --> 00:14:34,240
+Stop. Termination. Okay, so we have these verbs
+
+156
+00:14:34,240 --> 00:14:40,380
+refer to refer to a variety of time aspects okay
+
+157
+00:14:40,380 --> 00:14:44,320
+so we have either initiation continuation
+
+158
+00:14:44,320 --> 00:14:49,420
+repetition or termination these verbs in English
+
+159
+00:14:49,420 --> 00:14:54,260
+almost accept both infinitive and gerund except
+
+160
+00:14:54,260 --> 00:15:00,190
+only in termination we have some words related to
+
+161
+00:15:00,190 --> 00:15:04,770
+this matter. Okay? Mostly they accept only gerund.
+
+162
+00:15:05,350 --> 00:15:08,410
+Okay? He began to answer the question. He began
+
+163
+00:15:08,410 --> 00:15:11,470
+answering the question. We have a slight
+
+164
+00:15:11,470 --> 00:15:14,610
+difference between the two sentences. The first is
+
+165
+00:15:14,610 --> 00:15:18,550
+hypothetical. It is to happen. It's about to
+
+166
+00:15:18,550 --> 00:15:22,150
+happen. Okay? However, the second one already
+
+167
+00:15:22,150 --> 00:15:26,710
+happened or in progress. Okay?
+
+168
+00:15:36,600 --> 00:15:41,520
+The emotive verb does not refer to time.
+
+169
+00:15:42,380 --> 00:15:44,600
+Semantically, there is some sort of difference
+
+170
+00:15:44,600 --> 00:15:49,720
+between them. Okay. But it's the same meaning. I
+
+171
+00:15:49,720 --> 00:15:52,660
+know that the first one is not related to time and
+
+172
+00:15:52,660 --> 00:15:55,000
+the second one is not related to time. But we can
+
+173
+00:15:55,000 --> 00:15:59,380
+mingle between them or mix between them and have
+
+174
+00:15:59,380 --> 00:16:02,220
+the same meaning. The first category is a special
+
+175
+00:16:02,220 --> 00:16:04,040
+category. No, no. They are similar. They are
+
+176
+00:16:04,040 --> 00:16:07,280
+similar in their syntactic function. But
+
+177
+00:16:07,280 --> 00:16:11,340
+semantically they differ. Okay. And here we have a
+
+178
+00:16:11,340 --> 00:16:17,880
+big question that appears in this point why does
+
+179
+00:16:17,880 --> 00:16:26,260
+this verb accept infinitive or gerund and that
+
+180
+00:16:26,260 --> 00:16:30,260
+verb does not accept infinitive or does not accept
+
+181
+00:16:30,260 --> 00:16:35,300
+gerund okay so this is semantic question it needs
+
+182
+00:16:35,300 --> 00:16:39,940
+semantic interpretation that will be available
+
+183
+00:16:39,940 --> 00:16:45,200
+just later Okay? He began to answer the question.
+
+184
+00:16:45,660 --> 00:16:49,260
+He began answering the question. Having said that
+
+185
+00:16:49,260 --> 00:16:52,760
+he would be frank, we all commenced to listen to
+
+186
+00:16:52,760 --> 00:16:52,960
+him.
+
+187
+00:16:57,320 --> 00:17:00,860
+We all commenced to listen to him. Having said
+
+188
+00:17:00,860 --> 00:17:03,760
+that he would be frank, we all commenced listening
+
+189
+00:17:03,760 --> 00:17:07,140
+to him. Okay? So we speak about theoretical
+
+190
+00:17:07,140 --> 00:17:11,880
+actions and vivid or real actions. Okay?
+
+191
+00:17:17,420 --> 00:17:20,600
+So we have some verbs which refer to duration of
+
+192
+00:17:20,600 --> 00:17:25,980
+time, okay? That end with what is called
+
+193
+00:17:25,980 --> 00:17:30,380
+termination. These verbs which have this meaning
+
+194
+00:17:30,380 --> 00:17:35,040
+only accept gerund. John finished doing his
+
+195
+00:17:35,040 --> 00:17:39,180
+homework at midnight. We cannot say John finished
+
+196
+00:17:39,180 --> 00:17:46,100
+to do his homework. He quit smoking cigarettes. He
+
+197
+00:17:46,100 --> 00:17:47,140
+quit smoking.
+
+198
+00:17:50,240 --> 00:17:54,960
+The committee postponed making the decision on the
+
+199
+00:17:5
+
+223
+00:20:17,120 --> 00:20:19,320
+from Arabic to English.
+
+224
+00:20:22,120 --> 00:20:24,360
+Okay, or from English to Arabic.
+
+225
+00:20:27,320 --> 00:20:29,920
+Now, semantically,
+
+226
+00:20:32,760 --> 00:20:40,210
+the emotive verbs and aspectual verbs have
+
+227
+00:20:40,210 --> 00:20:42,870
+difference in meaning just in the use of
+
+228
+00:20:42,870 --> 00:20:48,650
+infinitive and gerund. So a sentence like, I love
+
+229
+00:20:48,650 --> 00:20:55,090
+to eat sandwiches. I love eating sandwiches. The
+
+230
+00:20:55,090 --> 00:20:58,110
+two sentences are different in meaning. The first
+
+231
+00:20:58,110 --> 00:21:02,110
+one is hypothetical. The second one is not fulfilled,
+
+232
+00:21:02,290 --> 00:21:07,290
+yes. And the second one is actual, achieved. Okay,
+
+233
+00:21:07,730 --> 00:21:11,900
+it's real. He stopped to smoke. He stopped
+
+234
+00:21:11,900 --> 00:21:13,540
+smoking. Could you translate?
+
+235
+00:21:16,220 --> 00:21:17,840
+He stopped to smoke.
+
+236
+00:21:21,500 --> 00:21:24,500
+Hard luck. Yes.
+
+237
+00:21:28,120 --> 00:21:28,780
+Yes.
+
+238
+00:21:39,660 --> 00:21:44,740
+The first sentence, Mary stopped to eat. I stopped
+
+239
+00:21:44,740 --> 00:21:48,520
+to smoke. He stopped doing an activity to smoke.
+
+240
+00:21:48,700 --> 00:21:53,120
+Yes. So he stopped to smoke. This means that he
+
+241
+00:21:53,120 --> 00:21:56,660
+stopped some action. He terminated, he quit some
+
+242
+00:21:56,660 --> 00:22:00,180
+action in order to have another action to smoke.
+
+243
+00:22:01,260 --> 00:22:08,210
+He stopped smoking. This means that he quit. So 
+
+244
+00:22:08,210 --> 00:22:12,110
+you have difference in meaning you have to take
+
+245
+00:22:12,110 --> 00:22:17,170
+care of that John forgot to buy the linguistics 
+
+246
+00:22:17,170 --> 00:22:25,210
+book John forgot to buy Sorry if John forgot 
+
+247
+00:22:25,210 --> 00:22:27,990
+buying the linguistics book. Is there any
+
+248
+00:22:27,990 --> 00:22:31,950
+difference? No, no difference at all.
+
+249
+00:22:34,940 --> 00:22:39,180
+So how can you interpret the two sentences? John
+
+250
+00:22:39,180 --> 00:22:43,660
+forgot to buy the linguistics book. John forgot
+
+251
+00:22:43,660 --> 00:22:48,700
+buying the linguistics book. Yes. He forgot to buy 
+
+252
+00:22:48,700 --> 00:22:57,680
+this
+
+253
+00:22:57,680 --> 00:23:01,880
+means that he forgot to buy this book, he has He 
+
+254
+00:23:01,880 --> 00:23:05,540
+hasn't bought it. However, the second one, he
+
+255
+00:23:05,540 --> 00:23:09,080
+bought the book, but he forgot that he bought it.
+
+256
+00:23:09,660 --> 00:23:09,920
+Okay?
+
+257
+00:23:16,460 --> 00:23:23,200
+Mary quit to cook. Mary quit cooking. Mary quit
+
+258
+00:23:23,200 --> 00:23:27,800
+cooking. Is there any difference? Yes. What about 
+
+259
+00:23:27,800 --> 00:23:32,910
+this group? Yes? that means Mary's stopped
+
+260
+00:23:32,910 --> 00:23:35,610
+activities but doing now in order to go and cook.
+
+261
+00:23:36,030 --> 00:23:39,410
+While Mary quit cooking, that Mary doesn't cook
+
+262
+00:23:39,410 --> 00:23:45,870
+anymore. Very good. Excellent. John remembered to
+
+263
+00:23:45,870 --> 00:23:50,690
+wash the plates. John remembered washing the
+
+264
+00:23:50,690 --> 00:23:54,930
+plates. Still, we have difference between the two
+
+265
+00:23:54,930 --> 00:23:58,940
+sentences semantically. So in translation, the two
+
+266
+00:23:58,940 --> 00:24:01,780
+sentences are different, are divergent. Who could 
+
+267
+00:24:01,780 --> 00:24:07,420
+translate them? John stopped to wash the plates.
+
+268
+00:24:08,260 --> 00:24:13,100
+John stopped washing the plates. It is the same.
+
+269
+00:24:13,380 --> 00:24:13,420
+Marco.
+
+270
+00:24:16,780 --> 00:24:22,340
+Iman? Yes, number two, that he, in the action 
+
+271
+00:24:22,340 --> 00:24:26,550
+order two, The first action is hypothetical, is
+
+272
+00:24:26,550 --> 00:24:30,710
+theoretical, that has not happened. Okay? He
+
+273
+00:24:30,710 --> 00:24:34,990
+remembered to wash. He did not wash. But the 
+
+274
+00:24:34,990 --> 00:24:39,570
+second one, he has already washed them, but he
+
+275
+00:24:39,570 --> 00:24:41,370
+forgot. Good.
+
+276
+00:24:46,530 --> 00:24:52,070
+Mary stopped to eat. Mary stopped eating. Mary 
+
+277
+00:24:52,070 --> 00:24:55,130
+stopped to eat or Mary stopped eating? The second 
+
+278
+00:24:55,130 --> 00:25:01,710
+one is that Mary stopped to eat. Mary stopped in
+
+279
+00:25:01,710 --> 00:25:08,910
+order to eat. However, the second one, she
+
+280
+00:25:08,910 --> 00:25:13,430
+finished or quit eating. Okay.
+
+281
+00:25:17,350 --> 00:25:20,850
+Do we have semantic distinction between the 
+
+282
+00:25:20,850 --> 00:25:24,070
+emotive verbs and aspectual verbs in Arabic? Do 
+
+283
+00:25:24,070 --> 00:25:26,450
+you have this semantic distinction in Arabic? Is 
+
+284
+00:25:26,450 --> 00:25:30,830
+this applicable to Arabic or not? Let's see. Okay,
+
+285
+00:25:30,830 --> 00:25:35,790
+I think that it corresponds to Arabic. The first 
+
+286
+00:25:35,790 --> 00:25:36,470
+one
+
+287
+00:25:47,400 --> 00:25:51,060
+refers to an action that has not happened. The 
+
+288
+00:25:51,060 --> 00:25:54,380
+second one refers to an action that happened but
+
+289
+00:25:54,380 --> 00:25:58,240
+forgotten. Okay? It's like English.
+
+290
+00:26:01,300 --> 00:26:06,140
+Now we come to the third category that is reactive
+
+291
+00:26:06,140 --> 00:26:11,840
+verbs. It refers to actions that are in progress.
+
+292
+00:26:13,710 --> 00:26:20,030
+The verbs which refer to reactive meaning only
+
+293
+00:26:20,030 --> 00:26:25,390
+accept gerund. They only accept gerund. Okay?
+
+294
+00:26:31,390 --> 00:26:32,350
+Yes.
+
+295
+00:26:37,710 --> 00:26:40,210
+These verbs only accept gerund. 
+
+296
+00:26:44,270 --> 00:26:51,770
+These are like resist, resent, repent, remember,
+
+297
+00:26:52,590 --> 00:26:58,570
+reject, regret, recommend, recall, abhor, enjoy,
+
+298
+00:26:59,210 --> 00:27:05,950
+dislike, detest, deny, consider, confess, okay?
+
+299
+00:27:06,310 --> 00:27:09,470
+Imagine, mind, and propose.
+
+300
+00:27:13,430 --> 00:27:16,430
+These verbs refer to what's called continuity, 
+
+301
+00:27:17,370 --> 00:27:21,970
+okay? Continuity of action or continuity in 
+
+302
+00:27:21,970 --> 00:27:27,670
+meaning. These only accept gerund. We discussed 
+
+303
+00:27:27,670 --> 00:27:29,850
+going to the zoo in the weekend. 
+
+304
+00:27:32,390 --> 00:27:37,210
+We can say we discussed to go to the zoo. The 
+
+305
+00:27:37,210 --> 00:27:39,990
+family has seriously considered selling the house. 
+
+306
+00:27:42,220 --> 00:27:45,280
+is not available to say the family has seriously
+
+307
+00:27:45,280 --> 00:27:49,100
+considered to sell the house. The suspect denies 
+
+308
+00:27:49,100 --> 00:27:54,980
+ever committing the crime. The suspect denies ever
+
+309
+00:27:54,980 --> 00:28:00,980
+to commit? No. He repented having shot the dog. He 
+
+310
+00:28:00,980 --> 00:28:05,380
+repented having shot it, not to have. Okay, 
+
+311
+00:28:05,380 --> 00:28:09,300
+because the action happened. So reactive verbs
+
+312
+00:28:09,300 --> 00:28:14,040
+refer to real actions, to vivid actions, to
+
+313
+00:28:14,040 --> 00:28:20,140
+actions which have been already done. Okay? Or at 
+
+314
+00:28:20,140 --> 00:28:25,980
+least in progress. So they only accept gerund.
+
+315
+00:28:26,860 --> 00:28:29,860
+Okay? Yes.
+
+316
+00:28:37,540 --> 00:28:46,980
+Yes. These emotive verbs, you see, they are in the
+
+317
+00:28:46,980 --> 00:28:50,820
+process of continuity. We speak about habitual
+
+318
+00:28:50,820 --> 00:28:56,040
+actions. Yes. We speak about habitual actions or 
+
+319
+00:28:56,040 --> 00:28:59,740
+actions which are more or less related to habits 
+
+320
+00:28:59,740 --> 00:29:05,960
+and customs. Okay? Actions which are associated
+
+321
+00:29:05,960 --> 00:29:11,640
+with daily work. I mean, the action already or 
+
+322
+00:29:11,640 --> 00:29:15,680
+always happens every day as accustomed by the 
+
+323
+00:29:15,680 --> 00:29:19,320
+subject or the doer of the action. Okay? So in 
+
+324
+00:29:19,320 --> 00:29:22,960
+that sense, we consider them reactive verbs. But
+
+325
+00:29:22,960 --> 00:29:26,120
+if you speak hypothetically or theoretically about
+
+326
+00:29:26,120 --> 00:29:33,370
+the verb as emotive verb, it takes both. Okay? He
+
+327
+00:29:33,370 --> 00:29:38,530
+detests socializing with students at school. He 
+
+328
+00:29:38,530 --> 00:29:42,310
+detests to socialize. This is a custom, permanent
+
+329
+00:29:42,310 --> 00:29:45,510
+custom with the speaker. I mean, his mood is like
+
+330
+00:29:45,510 --> 00:29:53,570
+this. The suspect confessed murdering the man. We
+
+331
+00:29:53,570 --> 00:29:56,430
+can't say that the subject confessed to murder the
+
+332
+00:29:56,430 --> 00:29:59,230
+man because the action happened.
+
+333
+00:30:02,820 --> 00:30:08,460
+We have Arabic, the Arabic reactive verbs. These
+
+334
+00:30:08,460 --> 00:30:26,700
+are like يثمن يناقش يقدر يقيم يقاوم يتذكر ينسى 
+
+335
+00:30:26,700 --> 00:30:32,660
+يتخيل And these verbs, as you see, accept both. 
+
+336
+00:30:33,400 --> 00:30:36,980
+Overt derived nominal and covert derived nominal.
+
+337
+00:30:37,580 --> 00:30:40,700
+They accept both. However, in English, they only
+
+338
+00:30:40,700 --> 00:30:48,180
+accept gerund. قَدَّرَ اللَّهُ أَن يَتِمَّ ذَلِكَ 
+
+339
+00:30:48,180 --> 00:30:54,280
+We can say also, قَدَّرَ اللَّهُ أَتْمَامَ ذَلِكَ 
+
+340
+00:30:54,280 --> 00:30:57,400
+لَنَ 
+
+341
+00:30:57,400 --> 00:31:04,550
+تَسَوَّر أن نقبل الظلم لا نتصور قبول الظلم so we
+
+342
+00:31:04,550 --> 00:31:13,650
+accept here we both are accepted يفضل 
+
+343
+00:31:13,650 --> 00:31:18,810
+عليهم أن يرفض
+
+344
+00:31:18,810 --> 00:31:23,390
+عليهم أن يظلم الناس يرفض عليهم ظلم الناس
+
+345
+00:31:29,050 --> 00:31:35,730
+يفترض زيدن أن يجيء عمرن يفترض زيدن ماجيء عمرن
+
+346
+00:31:35,730 --> 00:31:39,170
+يتطلب
+
+347
+00:31:39,170 --> 00:31:48,350
+النجاح الاشتهاد أو أن أشتهد يتطلب النجاح الاشتهاد 
+
+348
+00:31:48,350 --> 00:31:51,530
+okay, now the derived nominal in Arabic 
+
+349
+00:31:51,530 --> 00:31:56,370
+syntactically works as a verb, it assigns case
+
+350
+00:31:57,790 --> 00:32:02,890
+Mostly it assigns genitive case. It has the 
+
+351
+00:32:02,890 --> 00:32:05,870
+requirements of a verb. You know, the verb assigns
+
+352
+00:32:05,870 --> 00:32:12,710
+accusative case. كتب زيدن الدرسة. الدرسة is an
+
+353
+00:32:12,710 --> 00:32:16,330
+object. John wrote the lesson. The lesson is an 
+
+354
+00:32:16,330 --> 00:32:23,430
+object assigned accusative case. Okay? Now يفضل
+
+355
+00:32:23,430 --> 00:32:32,260
+زيدن كتابة الدرسي. الدرسي is an object, but here it
+
+356
+00:32:32,260 --> 00:32:35,940
+is we have the genitive case assigned to this noun,
+
+357
+00:32:35,940 --> 00:32:40,120
+this directly comes from the derived nominal, the
+
+358
+00:32:40,120 --> 00:32:48,820
+overt derived nominal. Okay, we
+
+359
+00:32:48,820 --> 00:32:51,360
+have some reactive verbs in Arabic only accept
+
+360
+00:32:51,360 --> 00:32:57,760
+nouns, not derived nominal like لا يثمن تعب
+
+361
+00:32:57,760 --> 00:33:04,900
+الوالدين بالنقود. Ta'ab is referred to as a noun 
+
+362
+00:33:04,900 --> 00:33:13,080
+in Arabic. لا يثمن أن يتعب الوالدين بالنقود. This
+
+363
+00:33:13,080 --> 00:33:16,660
+is not accepted. In case of having a noun coming 
+
+364
+00:33:16,660 --> 00:33:22,880
+after the reactive verb, then we have only the
+
+365
+00:33:22,880 --> 00:33:24,580
+overt derived nominal accepted. 
+
+366
+00:33:30,650 --> 00:33:39,410
+Okay? يقاوم الجنود هجوم العدو يقاوم الجنود أن يهجم
+
+367
+00:33:39,410 --> 00:33:39,870
+العدو يقاوم الجنود أن يهجم العدو يقاوم الجنود أن 
+
+368
+00:33:39,870 --> 00:33:44,370
+يهجم العدو يقاوم الجنود أن يهجم العدو يقاوم الجنود 
+
+369
+00:33:44,370 --> 00:33:45,370
+أن يهجم العدو يقاوم الجنود أن يهجم العدو يقاوم
+
+370
+00:33:45,370 --> 00:33:48,090
+الجنود أن يهجم العدو يقاوم الجنود أن يهجم العدو
+
+371
+00:33:48,090 --> 00:33:48,490
+يقاوم الجنود أن يهجم العدو يقاوم الجنود أن يهجم
+
+372
+00:33:48,490 --> 00:33:50,850
+يهجم العدو يقاوم الجنود أن يهجم العدو يقاوم الجنود
+
+373
+00:33:50,850 --> 00:33:56,150
+أن يهجم العد not a noun following the reactive
+
+374
+00:33:56,150 --> 00:34:00,890
+verb, then we have both derived nominal overt and 
+
+375
+00:34:00,890 --> 00:34:03,170
+covert or modified derived nominal.
+
+376
+00:34:05,850 --> 00:34:10,710
+We have the last category that is forward oriented
+
+377
+00:34:10,710 --> 00:34:11,190
+verbs.
+
+378
+00:34:14,020 --> 00:34:17,200
+These verbs refer to theoretical actions, to
+
+379
+00:34:17,200 --> 00:34:22,060
+hypothetical actions, to actions that will be 
+
+380
+00:34:22,060 --> 00:34:29,860
+fulfilled in future. Okay. So 
+
+381
+00:34:29,860 --> 00:34:34,780
+all the verbs here are hypothetical, and they 
+
+382
+00:34:34,780 --> 00:34:41,280
+accept only infinitive. Okay,
+
+383
+00:34:41,760 --> 00:34:47,860
+we expected to stop the security disorder soon.
+
+384
+00:34:48,660 --> 00:34:56,700
+Expect, hope, imagine. Okay? These verbs refer to
+
+385
+00:34:56,700 --> 00:35:03,320
+action that is to happen. Okay? We expect to stop
+
+386
+00:35:03,320 --> 00:35:06,080
+the security disorder. We cannot say we expect
+
+387
+00:35:06,080 --> 00:35:12,320
+stopping. We hope to submit the paper soon. We 
+
+388
+00:35:12,320 --> 00:35:16,880
+cannot say, we hope submitting. Okay? Because it
+
+389
+00:35:16,880 --> 00:35:21,200
+refers to action that has not happened. Okay? They
+
+390
+00:35:21,200 --> 00:35:25,140
+planned to spend the vacation in London. We cannot
+
+391
+00:35:25,140 --> 00:35:29,340
+say they planned spending because the action has
+
+392
+00:35:29,340 --> 00:35:30,160
+not happened yet.
+
+393
+00:35:35,860 --> 00:35:39,900
+Mary aspired to be a famous advocate. 
+
+394
+00:35:42,350 --> 00:35:46,110
+تتصور أنها ستكون. We speak about things which have
+
+395
+00:35:46,110 --> 00:35:49,890
+not been happened. So, the verbs like these are
+
+396
+00:35:49,890 --> 00:35:57,890
+like Britain, persuade, urge, tend, tell, order, 
+
+397
+00:35:58,490 --> 00:36:04,750
+learn, aspire, ask, force, fear, decline, agree,
+
+398
+00:36:05,770 --> 00:36:12,230
+we have managed, long seek, remind, refuse, swear,
+
+399
+00:36:13,670 --> 00:36:19,850
+mean, offer, strive, and vow. Okay? Of course, we
+
+400
+00:36:19,850 --> 00:36:29,070
+have hope as well. Own, and expect. Okay? Ahmed was
+
+401
+00:36:29,070 --> 00:36:34,730
+obliged to attend the
+
+402
+00:36:34,730 --> 00:36:35,050
+meeting. 
+
+403
+00:36:43,200 --> 00:36:47,880
+The suspect abstained to answer the detective's
+
+404
+00:36:47,880 --> 00:36:52,480
+questions. The action has not happened.
+
+405
+00:36:56,220 --> 00:37:00,200
+Now, if you look to Arabic, we also have forward 
+
+406
+00:37:00,200 --> 00:37:06,460
+-oriented verbs. Okay? They accept both modified 
+
+407
+00:37:06,460 --> 00:37:15,040
+and overt derived nominal. يتوقع يعني expect يخطط
+
+408
+00:37:15,040 --> 00:37:24,200
+يريد ينوي يصمم These verbs are forward oriental
+
+409
+00:37:24,200 --> 00:37:28,400
+verbs. They still have the meaning that has not
+
+410
+00:37:28,400 --> 00:37:30,420
+been fulfilled.
+
+411
+00:37:33,660 --> 00:37:43,040
+So يتوقع زيدن أن يصل أخاه من السفر اليوم أن يصل 
+
+412
+00:37:44,570 --> 00:37:48,030
+يتوقع زيدون وصول أخيه من السفر اليوم يتوقع زيدون 
+
+413
+00:37:48,030 --> 00:37:51,510
+وصول أخيه من السفر اليوم So they have both forward 
+
+414
+00:37:51,510 --> 00:37:5
+
+445
+00:40:39,850 --> 00:40:46,010
+other times we have only infinitive. This relies
+
+446
+00:40:46,010 --> 00:40:51,200
+on the lexical entry of the verb. The lexical
+
+447
+00:40:51,200 --> 00:40:53,860
+entry of the verb, the lexical capacity of the
+
+448
+00:40:53,860 --> 00:40:59,480
+verb. Okay? So it either accepts infinitive, it
+
+449
+00:40:59,480 --> 00:41:04,380
+either accepts gerund, it may accept both. Okay?
+
+450
+00:41:04,840 --> 00:41:09,960
+So it depends on the lexical capacity. Completely
+
+451
+00:41:09,960 --> 00:41:12,900
+like the verbs of giving, once accepting double
+
+452
+00:41:12,900 --> 00:41:18,990
+object construction. John gave Mary a book. John
+
+453
+00:41:18,990 --> 00:41:21,430
+gave a book to Mary. So we have double object
+
+454
+00:41:21,430 --> 00:41:29,350
+construction and we have dative construction. Okay.
+
+455
+00:41:29,350 --> 00:41:32,750
+Still
+
+456
+00:41:32,750 --> 00:41:36,090
+we have one object, the direct object plus the
+
+457
+00:41:36,090 --> 00:41:41,220
+dative object. John gave a book to Mary. Okay, so we
+
+458
+00:41:41,220 --> 00:41:44,280
+have this verb, the verbs of giving alternate
+
+459
+00:41:44,280 --> 00:41:47,900
+between double object construction and dative here.
+
+460
+00:41:47,900 --> 00:41:51,580
+We have these verbs. Some of them alternate between
+
+461
+00:41:51,580 --> 00:41:55,160
+accepting overt derived nominal in Arabic or
+
+462
+00:41:55,160 --> 00:42:00,620
+covert derived nominal, or gerund, or infinitive, or
+
+463
+00:42:00,620 --> 00:42:07,360
+both. This is attributed to the lexical entry of
+
+464
+00:42:07,360 --> 00:42:11,490
+the verb. Okay. The semantic capacity as well can
+
+465
+00:42:11,490 --> 00:42:14,990
+be considered. Okay. That's it for today. Thank
+
+466
+00:42:14,990 --> 00:42:15,130
+you.
diff --git a/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/CwFequR3Y5g_postprocess.srt b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/CwFequR3Y5g_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..7341878d7f1b8345cbcd071c33506afb7ec9ce2f
--- /dev/null
+++ b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/CwFequR3Y5g_postprocess.srt
@@ -0,0 +1,1864 @@
+1
+00:00:00,000 --> 00:00:00,800
+You.
+
+2
+00:00:34,780 --> 00:00:38,200
+Bismillah ar-Rahman ar-Rahim. Today we are going
+
+3
+00:00:38,200 --> 00:00:42,360
+to continue with infinitive and gerund in English
+
+4
+00:00:42,360 --> 00:00:47,800
+versus overt and covert derived nominal in Arabic.
+
+5
+00:00:52,260 --> 00:00:55,860
+Last time we saw the function, we've seen the
+
+6
+00:00:55,860 --> 00:00:59,820
+function of the syntactic function of infinitive
+
+7
+00:00:59,820 --> 00:01:03,120
+in English. We mentioned that the syntactic
+
+8
+00:01:03,120 --> 00:01:09,390
+function covers Four points. The infinitive can be
+
+9
+00:01:09,390 --> 00:01:10,510
+a subject.
+
+10
+00:01:13,950 --> 00:01:19,710
+Yes. Can stand as a subject, as object, as subject
+
+11
+00:01:19,710 --> 00:01:25,710
+complement, and object complement. Okay? This is
+
+12
+00:01:25,710 --> 00:01:30,870
+in English. It is also the same in Arabic. We have
+
+13
+00:01:30,870 --> 00:01:36,370
+the derived nominal, derived nominal stands as a
+
+14
+00:01:36,370 --> 00:01:41,610
+subject, as object, as subject complement, or
+
+15
+00:01:41,610 --> 00:01:42,490
+object complement.
+
+16
+00:01:53,450 --> 00:01:56,690
+Then we shifted to what is called sensation verbs.
+
+17
+00:01:58,510 --> 00:02:03,160
+We've seen that the sensation verbs like C, Here,
+
+18
+00:02:03,900 --> 00:02:12,620
+touch, notice. Look, these only accept bare
+
+19
+00:02:12,620 --> 00:02:16,720
+infinitive. Bare infinitive. Yani infinitive
+
+20
+00:02:16,720 --> 00:02:20,500
+without to. Okay? I heard them talk about the
+
+21
+00:02:20,500 --> 00:02:25,340
+plan. I heard them talk about the plan. I saw Ali
+
+22
+00:02:25,340 --> 00:02:29,420
+stand at the gate. I noticed her pick a flower.
+
+23
+00:02:30,380 --> 00:02:34,970
+Okay? However, in Arabic, we don't have bare
+
+24
+00:02:34,970 --> 00:02:41,030
+infinitive. We have the present imperfect
+
+25
+00:02:41,030 --> 00:02:44,990
+indicative form of the verb. This means that the
+
+26
+00:02:44,990 --> 00:02:49,030
+verb stands with inflections. We have persons
+
+27
+00:02:49,030 --> 00:02:54,330
+added to the verb. Samaatuhu yatakellamu 3an
+
+28
+00:02:54,330 --> 00:02:59,730
+alkhatta. Samaatuhu yatakellam. Okay, so
+
+29
+00:02:59,730 --> 00:03:04,500
+yatakellam, this is present. Verb present in
+
+30
+00:03:04,500 --> 00:03:10,300
+perfect indicative form. Yeah this is third person
+
+31
+00:03:10,300 --> 00:03:18,720
+inflection in Arabic يتكلم تكلم أتكلم sorry يتكلم
+
+32
+00:03:18,720 --> 00:03:22,880
+أتكلم نتكلم تتكلم so we have four inflections
+
+33
+00:03:22,880 --> 00:03:27,930
+representing persons in Arabic okay it's different
+
+34
+00:03:27,930 --> 00:03:31,810
+from English which has only one inflection that is
+
+35
+00:03:31,810 --> 00:03:39,870
+the subject verb agreement us okay
+
+36
+00:03:39,870 --> 00:03:44,530
+still we have three verbs in English which are
+
+37
+00:03:44,530 --> 00:03:50,090
+related to sensation verbs these are like help let
+
+38
+00:03:50,090 --> 00:03:56,180
+and and make yes let help and make these accept
+
+39
+00:03:56,180 --> 00:04:03,860
+both their infinitive and to infinitive now this
+
+40
+00:04:03,860 --> 00:04:07,380
+cannot be corresponded to Arabic since Arabic has
+
+41
+00:04:07,380 --> 00:04:12,640
+the inflections added to the verb okay دعه يتكلم
+
+42
+00:04:12,640 --> 00:04:13,460
+عن الخطة
+
+43
+00:04:18,340 --> 00:04:25,160
+present in perfect indicative form of the verb now
+
+44
+00:04:25,160 --> 00:04:30,340
+we have a problem with infinitives and gerunds
+
+45
+00:04:30,340 --> 00:04:33,760
+verbs which accept infinitives infinitive or
+
+46
+00:04:33,760 --> 00:04:40,040
+gerund we just have
+
+47
+00:04:40,040 --> 00:04:44,370
+this point Very tricky just for it appears very
+
+48
+00:04:44,370 --> 00:04:48,970
+tricky for our students since they confuse just in
+
+49
+00:04:48,970 --> 00:04:52,630
+using either infinitive or gerund. So they commit
+
+50
+00:04:52,630 --> 00:04:57,050
+serious mistakes in this side. Most of them are
+
+51
+00:04:57,050 --> 00:05:02,090
+interlingual or interlingual? Interlingual. These
+
+52
+00:05:02,090 --> 00:05:05,230
+are interlingual. Interlingual.
+
+53
+00:05:14,340 --> 00:05:20,440
+Most of them are intralingual. So we try to solve
+
+54
+00:05:20,440 --> 00:05:29,250
+this problem by having a new account. a theory
+
+55
+00:05:29,250 --> 00:05:33,750
+that accounts for the use of infinitive or gerund.
+
+56
+00:05:34,330 --> 00:05:37,250
+But before introducing this theory, we need to
+
+57
+00:05:37,250 --> 00:05:40,770
+introduce the previous theories in this or the
+
+58
+00:05:40,770 --> 00:05:44,030
+previous principles in this regard. We have
+
+59
+00:05:44,030 --> 00:05:50,350
+Bollinger's principle, okay, in which the choice
+
+60
+00:05:50,350 --> 00:05:53,750
+of infinitive correlates in some degree with
+
+61
+00:05:53,750 --> 00:05:58,160
+events that are theoretical or hypothetical. Okay,
+
+62
+00:05:58,580 --> 00:06:02,680
+or hypothetical, all hypothetical actions are in,
+
+63
+00:06:03,620 --> 00:06:08,320
+they take infinitive. However, the vivid or actual
+
+64
+00:06:08,320 --> 00:06:14,760
+or already fulfilled actions are gerund. Okay, so
+
+65
+00:06:14,760 --> 00:06:18,460
+speak about real actions that take gerund. We have
+
+66
+00:06:18,460 --> 00:06:23,080
+hypothetical actions which only take infinitive.
+
+67
+00:06:23,500 --> 00:06:26,620
+Speak about things which will happen. This is
+
+68
+00:06:26,620 --> 00:06:30,940
+infinitive. Things which have already happened or
+
+69
+00:06:30,940 --> 00:06:36,020
+are in progress, they take gerund as well. Okay?
+
+70
+00:06:36,500 --> 00:06:39,800
+But applying this principle on the verb, for
+
+71
+00:06:39,800 --> 00:06:44,700
+example, start, comes out with negative results.
+
+72
+00:06:45,840 --> 00:06:49,360
+It stands to rain. Sorry, it's start. It starts to
+
+73
+00:06:49,360 --> 00:06:53,240
+rain. It starts raining. Is there any difference
+
+74
+00:06:53,240 --> 00:06:57,450
+in translation? There's no difference. Okay?
+
+75
+00:06:57,570 --> 00:07:01,190
+There's no difference. Richard continued to work.
+
+76
+00:07:01,690 --> 00:07:06,050
+Richard continued working. Okay? We don't have
+
+77
+00:07:06,050 --> 00:07:10,010
+dissimilarities or any difference just in
+
+78
+00:07:10,010 --> 00:07:13,210
+translating these two sentences. I prefer to eat
+
+79
+00:07:13,210 --> 00:07:18,730
+sandwiches. I prefer eating sandwiches. So, these
+
+80
+00:07:18,730 --> 00:07:22,890
+verbs start, prefer, continue
+
+81
+00:07:25,720 --> 00:07:32,440
+cannot accept Bollinger's principle. This
+
+82
+00:07:32,440 --> 00:07:37,960
+necessitates thinking of a new principle that can
+
+83
+00:07:37,960 --> 00:07:42,020
+be applied on all the verbs of English which
+
+84
+00:07:42,020 --> 00:07:46,780
+accept either infinitive or gerund or both we are
+
+85
+00:07:46,780 --> 00:07:49,820
+in front of some verbs which accept both the
+
+86
+00:07:49,820 --> 00:07:53,640
+alternate between infinitive and gerund and some
+
+87
+00:07:53,640 --> 00:07:58,780
+other verbs only accept gerund we have verbs only
+
+88
+00:07:58,780 --> 00:08:02,840
+accept infinitive so
+
+89
+00:08:05,510 --> 00:08:12,910
+I came with a new account which divides the verbs
+
+90
+00:08:12,910 --> 00:08:17,510
+accepting infinitive and gerund or either one of
+
+91
+00:08:17,510 --> 00:08:22,910
+them. I divided them into four categories. Okay.
+
+92
+00:08:23,310 --> 00:08:29,110
+First of all, the emotive verbs, aspectual verbs,
+
+93
+00:08:30,450 --> 00:08:35,480
+reactive verbs and forward oriented verbs. Okay?
+
+94
+00:08:36,040 --> 00:08:41,960
+So for emotive verbs, these
+
+95
+00:08:41,960 --> 00:08:50,600
+verbs are not associated with time. Okay? They are
+
+96
+00:08:50,600 --> 00:08:55,320
+like dread, hate, like, love, lose, prefer, and
+
+97
+00:08:55,320 --> 00:09:01,040
+rejoice. These verbs are not connected to time.
+
+98
+00:09:01,680 --> 00:09:07,810
+Okay? So they accept both infinitive and gerund. I
+
+99
+00:09:07,810 --> 00:09:11,290
+hated to meet the boss. I hated meeting the boss.
+
+100
+00:09:12,390 --> 00:09:16,690
+We have difference in translation here. The first
+
+101
+00:09:16,690 --> 00:09:21,150
+sentence refers to an action that has not
+
+102
+00:09:21,150 --> 00:09:26,010
+happened. Okay? Future action. Okay? The second
+
+103
+00:09:26,010 --> 00:09:30,330
+one refers to an action which happened. Okay?
+
+104
+00:09:32,840 --> 00:09:35,460
+Would you like to see my dad? Would you like
+
+105
+00:09:35,460 --> 00:09:36,260
+seeing my dad?
+
+106
+00:09:39,600 --> 00:09:43,280
+Here we have also some sort of difference between
+
+107
+00:09:43,280 --> 00:09:46,760
+the two sentences. The first one, the verb see,
+
+108
+00:09:47,300 --> 00:09:51,660
+refers to, I mean, the infinitive to see refers to
+
+109
+00:09:51,660 --> 00:09:56,280
+future action, hypothetical action. However, the
+
+110
+00:09:56,280 --> 00:10:02,960
+second one refers to real action, okay? Do you
+
+111
+00:10:02,960 --> 00:10:07,100
+prefer to read the daily or watch the TV? Or to
+
+112
+00:10:07,100 --> 00:10:10,480
+watch the TV? Do you prefer reading the daily or
+
+113
+00:10:10,480 --> 00:10:14,060
+watching the TV? Again, the first sentence is
+
+114
+00:10:14,060 --> 00:10:17,160
+hypothetical. It is theoretical, refers to an
+
+115
+00:10:17,160 --> 00:10:20,800
+action that is to happen. However, the second one
+
+116
+00:10:20,800 --> 00:10:25,280
+refers to a habit which actually happens every
+
+117
+00:10:25,280 --> 00:10:28,360
+day. I mean action which already happened. We
+
+118
+00:10:28,360 --> 00:10:31,180
+speak about vivid or real action which is
+
+119
+00:10:31,180 --> 00:10:31,700
+fulfilled.
+
+120
+00:10:37,380 --> 00:10:40,780
+Do we have emotive verbs in Arabic? What about
+
+121
+00:10:40,780 --> 00:10:45,120
+their structure? Yes, we have emotive verbs in
+
+122
+00:10:45,120 --> 00:11:00,440
+Arabic like يفضل يخاف يبغض يكره يحب يخشى يعجب يعشق
+
+123
+00:11:00,440 --> 00:11:06,380
+etc These are emotive verbs They touch the feeling
+
+124
+00:11:08,060 --> 00:11:13,920
+They are not related to time influence. Okay? We
+
+125
+00:11:13,920 --> 00:11:20,680
+have يحب زيد قراءة القرآن. يحب زيد أن يقرأ القرآن.
+
+126
+00:11:21,360 --> 00:11:25,100
+So they accept both. So the emotive verbs of
+
+127
+00:11:25,100 --> 00:11:28,300
+Arabic are the same like the emotive verbs of
+
+128
+00:11:28,300 --> 00:11:28,700
+English.
+
+129
+00:11:36,040 --> 00:11:44,460
+Yes. We have يكره الولد اللعب في الشارع يكره الولد
+
+130
+00:11:44,460 --> 00:11:49,900
+اللعب في الشارع So we have the first sentence it
+
+131
+00:11:49,900 --> 00:11:53,840
+is of overt derived nominal while the second one
+
+132
+00:11:53,840 --> 00:12:02,620
+is of a modified derived nominal يفضل
+
+133
+00:12:02,620 --> 00:12:07,380
+زيدن شرب الشاي Overt, derived nominal, as you see.
+
+134
+00:12:07,720 --> 00:12:09,860
+يفضل زيد أن يشرب الشاي.
+
+135
+00:12:14,740 --> 00:12:20,620
+يخاف المؤمن ارتكاب الكبار. يخاف المؤمن أن يرتكب
+
+136
+00:12:20,620 --> 00:12:24,840
+الكبار. So we have overt derived nominal and
+
+137
+00:12:24,840 --> 00:12:27,760
+covert derived nominal within the same time. So
+
+138
+00:12:27,760 --> 00:12:31,540
+this, I mean the emotive verbs, the emotive verbs
+
+139
+00:12:33,380 --> 00:12:37,360
+are alternating between infinitive and gerund.
+
+140
+00:12:39,720 --> 00:12:41,940
+What about aspectual verbs?
+
+141
+00:12:45,200 --> 00:12:52,380
+They are associated with time. Yes. The aspectual
+
+142
+00:12:52,380 --> 00:12:55,620
+verbs are associated to time. They refer to a
+
+143
+00:12:55,620 --> 00:13:02,670
+variety of time. Okay? So these refer to a variety
+
+144
+00:13:02,670 --> 00:13:08,910
+of time aspects like initiation, continuation,
+
+145
+00:13:09,670 --> 00:13:14,090
+repetition, termination. So we have verbs like
+
+146
+00:13:14,090 --> 00:13:16,650
+begin.
+
+147
+00:13:17,150 --> 00:13:20,730
+This is initiation. Resume.
+
+148
+00:13:23,870 --> 00:13:27,870
+Resume. This is repetition. Okay.
+
+149
+00:13:34,950 --> 00:13:40,690
+It is more related to repetition. You repeat the
+
+150
+00:13:40,690 --> 00:13:48,830
+action. Okay? Remain. Continuation. Commence.
+
+151
+00:13:50,030 --> 00:13:55,570
+Initiation. Finish. Continue. Discontinue.
+
+152
+00:13:59,630 --> 00:14:11,050
+Termination. End up. Seize. Repeat. Complete. Give
+
+153
+00:14:11,050 --> 00:14:20,290
+up. Postpone. Proceed. Continuation. Quit. Keep.
+
+154
+00:14:20,550 --> 00:14:27,610
+Keep on. Start. Initiation. Stay. Continuation.
+
+155
+00:14:27,690 --> 00:14:34,240
+Stop. Termination. Okay, so we have these verbs
+
+156
+00:14:34,240 --> 00:14:40,380
+refer to refer to a variety of time aspects okay
+
+157
+00:14:40,380 --> 00:14:44,320
+so we have either initiation continuation
+
+158
+00:14:44,320 --> 00:14:49,420
+repetition or termination these verbs in English
+
+159
+00:14:49,420 --> 00:14:54,260
+almost accept both infinitive and gerund except
+
+160
+00:14:54,260 --> 00:15:00,190
+only in termination we have some words related to
+
+161
+00:15:00,190 --> 00:15:04,770
+this matter. Okay? Mostly they accept only gerund.
+
+162
+00:15:05,350 --> 00:15:08,410
+Okay? He began to answer the question. He began
+
+163
+00:15:08,410 --> 00:15:11,470
+answering the question. We have a slight
+
+164
+00:15:11,470 --> 00:15:14,610
+difference between the two sentences. The first is
+
+165
+00:15:14,610 --> 00:15:18,550
+hypothetical. It is to happen. It's about to
+
+166
+00:15:18,550 --> 00:15:22,150
+happen. Okay? However, the second one already
+
+167
+00:15:22,150 --> 00:15:26,710
+happened or in progress. Okay?
+
+168
+00:15:36,600 --> 00:15:41,520
+The emotive verb does not refer to time.
+
+169
+00:15:42,380 --> 00:15:44,600
+Semantically, there is some sort of difference
+
+170
+00:15:44,600 --> 00:15:49,720
+between them. Okay. But it's the same meaning. I
+
+171
+00:15:49,720 --> 00:15:52,660
+know that the first one is not related to time and
+
+172
+00:15:52,660 --> 00:15:55,000
+the second one is not related to time. But we can
+
+173
+00:15:55,000 --> 00:15:59,380
+mingle between them or mix between them and have
+
+174
+00:15:59,380 --> 00:16:02,220
+the same meaning. The first category is a special
+
+175
+00:16:02,220 --> 00:16:04,040
+category. No, no. They are similar. They are
+
+176
+00:16:04,040 --> 00:16:07,280
+similar in their syntactic function. But
+
+177
+00:16:07,280 --> 00:16:11,340
+semantically they differ. Okay. And here we have a
+
+178
+00:16:11,340 --> 00:16:17,880
+big question that appears in this point why does
+
+179
+00:16:17,880 --> 00:16:26,260
+this verb accept infinitive or gerund and that
+
+180
+00:16:26,260 --> 00:16:30,260
+verb does not accept infinitive or does not accept
+
+181
+00:16:30,260 --> 00:16:35,300
+gerund okay so this is semantic question it needs
+
+182
+00:16:35,300 --> 00:16:39,940
+semantic interpretation that will be available
+
+183
+00:16:39,940 --> 00:16:45,200
+just later Okay? He began to answer the question.
+
+184
+00:16:45,660 --> 00:16:49,260
+He began answering the question. Having said that
+
+185
+00:16:49,260 --> 00:16:52,760
+he would be frank, we all commenced to listen to
+
+186
+00:16:52,760 --> 00:16:52,960
+him.
+
+187
+00:16:57,320 --> 00:17:00,860
+We all commenced to listen to him. Having said
+
+188
+00:17:00,860 --> 00:17:03,760
+that he would be frank, we all commenced listening
+
+189
+00:17:03,760 --> 00:17:07,140
+to him. Okay? So we speak about theoretical
+
+190
+00:17:07,140 --> 00:17:11,880
+actions and vivid or real actions. Okay?
+
+191
+00:17:17,420 --> 00:17:20,600
+So we have some verbs which refer to duration of
+
+192
+00:17:20,600 --> 00:17:25,980
+time, okay? That end with what is called
+
+193
+00:17:25,980 --> 00:17:30,380
+termination. These verbs which have this meaning
+
+194
+00:17:30,380 --> 00:17:35,040
+only accept gerund. John finished doing his
+
+195
+00:17:35,040 --> 00:17:39,180
+homework at midnight. We cannot say John finished
+
+196
+00:17:39,180 --> 00:17:46,100
+to do his homework. He quit smoking cigarettes. He
+
+197
+00:17:46,100 --> 00:17:47,140
+quit smoking.
+
+198
+00:17:50,240 --> 00:17:54,960
+The committee postponed making the decision on the
+
+199
+00:17:54,960 --> 00:18:00,900
+matter. We'll stop for an hour and resume working
+
+200
+00:18:00,900 --> 00:18:06,560
+at three o'clock. So we have these verbs only
+
+201
+00:18:06,560 --> 00:18:14,820
+accept gerunds. Because they refer to a duration
+
+202
+00:18:14,820 --> 00:18:21,460
+of time. Okay We
+
+203
+00:18:21,460 --> 00:18:27,920
+have aspectual verbs in Arabic as well These
+
+204
+00:18:27,920 --> 00:18:37,640
+aspectual verbs Are
+
+205
+00:18:37,640 --> 00:18:44,000
+like يستأنف يوقف
+
+206
+00:18:47,920 --> 00:18:52,820
+يستمر يواصل ينهي
+
+207
+00:18:52,820 --> 00:18:56,380
+ينهي
+
+208
+00:18:56,380 --> 00:19:02,680
+يؤجل we
+
+209
+00:19:02,680 --> 00:19:06,860
+speak about aspectual verbs okay we spoke about
+
+210
+00:19:06,860 --> 00:19:09,760
+them in English and found that they accept both
+
+211
+00:19:09,760 --> 00:19:14,420
+infinitive and gerund now we have aspectual verbs
+
+212
+00:19:14,420 --> 00:19:22,640
+of Arabic As we mentioned, these verbs only accept
+
+213
+00:19:22,640 --> 00:19:29,060
+overt derived nominal. For example, يبدأ المعلم
+
+214
+00:19:29,060 --> 00:19:34,020
+مناقشة الطلاب. We cannot say يبدأ المعلم أن يناقش
+
+215
+00:19:34,020 --> 00:19:35,580
+الطلاب. It's not accepted.
+
+216
+00:19:43,630 --> 00:19:49,970
+يبتدئ المعلم أن يناقش الطلاب is not accepted ينهي
+
+217
+00:19:49,970 --> 00:19:55,430
+علي كتابة الدرس ينهي
+
+218
+00:19:55,430 --> 00:20:00,930
+علي أن يكتب الدرس is not accepted so aspectual
+
+219
+00:20:00,930 --> 00:20:04,830
+verbs in Arabic only accept overt derived nominal
+
+220
+00:20:04,830 --> 00:20:09,330
+however in English they accept both except the
+
+221
+00:20:09,330 --> 00:20:14,440
+verbs of termination so you have to take care you
+
+222
+00:20:14,440 --> 00:20:17,120
+have to be very careful just once you translate
+
+223
+00:20:17,120 --> 00:20:19,320
+from Arabic to English.
+
+224
+00:20:22,120 --> 00:20:24,360
+Okay, or from English to Arabic.
+
+225
+00:20:27,320 --> 00:20:29,920
+Now, semantically,
+
+226
+00:20:32,760 --> 00:20:40,210
+the emotive verbs and aspectual verbs have
+
+227
+00:20:40,210 --> 00:20:42,870
+difference in meaning just in the use of
+
+228
+00:20:42,870 --> 00:20:48,650
+infinitive and gerund. So a sentence like, I love
+
+229
+00:20:48,650 --> 00:20:55,090
+to eat sandwiches. I love eating sandwiches. The
+
+230
+00:20:55,090 --> 00:20:58,110
+two sentences are different in meaning. The first
+
+231
+00:20:58,110 --> 00:21:02,110
+one is hypothetical. The second one not fulfilled,
+
+232
+00:21:02,290 --> 00:21:07,290
+yes. And the second one is actual, achieved. Okay,
+
+233
+00:21:07,730 --> 00:21:11,900
+it's real. He stopped to smoke. He stopped
+
+234
+00:21:11,900 --> 00:21:13,540
+smoking. Could you translate?
+
+235
+00:21:16,220 --> 00:21:17,840
+He stopped to smoke.
+
+236
+00:21:21,500 --> 00:21:24,500
+Hard luck. Yes.
+
+237
+00:21:28,120 --> 00:21:28,780
+Yes.
+
+238
+00:21:39,660 --> 00:21:44,740
+The first sentence, Mary stopped to eat. I stopped
+
+239
+00:21:44,740 --> 00:21:48,520
+to smoke. He stopped doing an activity to smoke.
+
+240
+00:21:48,700 --> 00:21:53,120
+Yes. So he stopped to smoke. This means that he
+
+241
+00:21:53,120 --> 00:21:56,660
+stopped some action. He terminated, he quit some
+
+242
+00:21:56,660 --> 00:22:00,180
+action in order to have another action to smoke.
+
+243
+00:22:01,260 --> 00:22:08,210
+He stopped smoking. This means that he quit. So
+
+244
+00:22:08,210 --> 00:22:12,110
+you have difference in meaning you have to take
+
+245
+00:22:12,110 --> 00:22:17,170
+care of that John forgot to buy the linguistics
+
+246
+00:22:17,170 --> 00:22:25,210
+book John forgot to buy Sorry if John forgot
+
+247
+00:22:25,210 --> 00:22:27,990
+buying the linguistics book is there any
+
+248
+00:22:27,990 --> 00:22:31,950
+difference No, no difference at all
+
+249
+00:22:34,940 --> 00:22:39,180
+So how can you interpret the two sentences? John
+
+250
+00:22:39,180 --> 00:22:43,660
+forgot to buy the linguistics book. John forgot
+
+251
+00:22:43,660 --> 00:22:48,700
+buying the linguistics book. Yes. He forgot to buy
+
+252
+00:22:48,700 --> 00:22:57,680
+this
+
+253
+00:22:57,680 --> 00:23:01,880
+means that he forgot to buy this book he has He
+
+254
+00:23:01,880 --> 00:23:05,540
+hasn't bought it. However, the second one, he
+
+255
+00:23:05,540 --> 00:23:09,080
+bought the book, but he forgot that he bought it.
+
+256
+00:23:09,660 --> 00:23:09,920
+Okay?
+
+257
+00:23:16,460 --> 00:23:23,200
+Mary quit to cook. Mary quit cooking. Mary quit
+
+258
+00:23:23,200 --> 00:23:27,800
+cooking. Is there any difference? Yes. What about
+
+259
+00:23:27,800 --> 00:23:32,910
+this group? Yes? that means Mary's stopped
+
+260
+00:23:32,910 --> 00:23:35,610
+activities but doing now in order to go and cook.
+
+261
+00:23:36,030 --> 00:23:39,410
+While Mary quit cooking, that Mary doesn't cook
+
+262
+00:23:39,410 --> 00:23:45,870
+anymore. Very good. Excellent. John remembered to
+
+263
+00:23:45,870 --> 00:23:50,690
+wash the plates. John remembered washing the
+
+264
+00:23:50,690 --> 00:23:54,930
+plates. Still, we have difference between the two
+
+265
+00:23:54,930 --> 00:23:58,940
+sentences semantically. So in translation, The two
+
+266
+00:23:58,940 --> 00:24:01,780
+sentences are different, are divergent. Who could
+
+267
+00:24:01,780 --> 00:24:07,420
+translate them? John stopped to wash the plates.
+
+268
+00:24:08,260 --> 00:24:13,100
+John stopped washing the plates. It is the same.
+
+269
+00:24:13,380 --> 00:24:13,420
+Marco.
+
+270
+00:24:16,780 --> 00:24:22,340
+Iman? Yes, number two, that he, in the action
+
+271
+00:24:22,340 --> 00:24:26,550
+order two, The first action is hypothetical, is
+
+272
+00:24:26,550 --> 00:24:30,710
+theoretical, that has not happened. Okay? He
+
+273
+00:24:30,710 --> 00:24:34,990
+remembered to wash. He did not wash. But the
+
+274
+00:24:34,990 --> 00:24:39,570
+second one, he has already washed them, but he
+
+275
+00:24:39,570 --> 00:24:41,370
+forgot. Good.
+
+276
+00:24:46,530 --> 00:24:52,070
+Mary stopped to eat. Mary stopped eating. Mary
+
+277
+00:24:52,070 --> 00:24:55,130
+stopped to eat or Mary stopped eating? The second
+
+278
+00:24:55,130 --> 00:25:01,710
+one is that Mary stopped to eat. Mary stopped in
+
+279
+00:25:01,710 --> 00:25:08,910
+order to eat. However, the second one, she
+
+280
+00:25:08,910 --> 00:25:13,430
+finished or quit eating. Okay.
+
+281
+00:25:17,350 --> 00:25:20,850
+Do we have semantic distinction between the
+
+282
+00:25:20,850 --> 00:25:24,070
+emotive verbs and aspectual verbs in Arabic? Do
+
+283
+00:25:24,070 --> 00:25:26,450
+you have this semantic distinction in Arabic? Is
+
+284
+00:25:26,450 --> 00:25:30,830
+this applicable to Arabic or not? Let's see Okay,
+
+285
+00:25:30,830 --> 00:25:35,790
+I think that it corresponds to Arabic The first
+
+286
+00:25:35,790 --> 00:25:36,470
+one
+
+287
+00:25:47,400 --> 00:25:51,060
+refers to an action that has not happened. The
+
+288
+00:25:51,060 --> 00:25:54,380
+second one refers to an action that happened but
+
+289
+00:25:54,380 --> 00:25:58,240
+forgotten. Okay? It's like English.
+
+290
+00:26:01,300 --> 00:26:06,140
+Now we come to the third category that is reactive
+
+291
+00:26:06,140 --> 00:26:11,840
+verbs. It refers to actions that are in progress.
+
+292
+00:26:13,710 --> 00:26:20,030
+The verbs which refer to reactive meaning only
+
+293
+00:26:20,030 --> 00:26:25,390
+accept gerund. They only accept gerund. Okay?
+
+294
+00:26:31,390 --> 00:26:32,350
+Yes.
+
+295
+00:26:37,710 --> 00:26:40,210
+These verbs only accept gerund.
+
+296
+00:26:44,270 --> 00:26:51,770
+These are like resist, resent, repent, remember,
+
+297
+00:26:52,590 --> 00:26:58,570
+reject, regret, recommend, recall, abhor, enjoy,
+
+298
+00:26:59,210 --> 00:27:05,950
+dislike, detest, deny, consider, confess, okay?
+
+299
+00:27:06,310 --> 00:27:09,470
+Imagine, mind, and propose.
+
+300
+00:27:13,430 --> 00:27:16,430
+These verbs refer to what's called continuity,
+
+301
+00:27:17,370 --> 00:27:21,970
+okay? Continuity of action or continuity in
+
+302
+00:27:21,970 --> 00:27:27,670
+meaning. These only accept gerund. We discussed
+
+303
+00:27:27,670 --> 00:27:29,850
+going to the zoo in the weekend.
+
+304
+00:27:32,390 --> 00:27:37,210
+We can say we discussed to go to the zoo. The
+
+305
+00:27:37,210 --> 00:27:39,990
+family has seriously considered selling the house.
+
+306
+00:27:42,220 --> 00:27:45,280
+is not available to say the family has seriously
+
+307
+00:27:45,280 --> 00:27:49,100
+considered to sell the house. The suspect denies
+
+308
+00:27:49,100 --> 00:27:54,980
+ever committing the crime. The suspect denies ever
+
+309
+00:27:54,980 --> 00:28:00,980
+to commit? No. He repented having shot the dog. He
+
+310
+00:28:00,980 --> 00:28:05,380
+repented having shot it, not to have. Okay,
+
+311
+00:28:05,380 --> 00:28:09,300
+because the action happened. So reactive verbs
+
+312
+00:28:09,300 --> 00:28:14,040
+refer to real actions, to vivid actions, to
+
+313
+00:28:14,040 --> 00:28:20,140
+actions which have been already done. Okay? Or at
+
+314
+00:28:20,140 --> 00:28:25,980
+least in progress. So they only accept gerund.
+
+315
+00:28:26,860 --> 00:28:29,860
+Okay? Yes.
+
+316
+00:28:37,540 --> 00:28:46,980
+Yes. These emotive verbs, you see, they are in the
+
+317
+00:28:46,980 --> 00:28:50,820
+process of continuity. We speak about habitual
+
+318
+00:28:50,820 --> 00:28:56,040
+actions. Yes. We speak about habitual actions or
+
+319
+00:28:56,040 --> 00:28:59,740
+actions which are more or less related to habits
+
+320
+00:28:59,740 --> 00:29:05,960
+and customs. Okay? Actions which are associated
+
+321
+00:29:05,960 --> 00:29:11,640
+with daily work. I mean, the action already or
+
+322
+00:29:11,640 --> 00:29:15,680
+always happens every day as accustomed by the
+
+323
+00:29:15,680 --> 00:29:19,320
+subject or the doer of the action. Okay? So in
+
+324
+00:29:19,320 --> 00:29:22,960
+that sense, we consider them reactive verbs. But
+
+325
+00:29:22,960 --> 00:29:26,120
+if you speak hypothetically or theoretically about
+
+326
+00:29:26,120 --> 00:29:33,370
+the verb as emotive verb, it takes both. Okay? He
+
+327
+00:29:33,370 --> 00:29:38,530
+detests socializing with students at school. He
+
+328
+00:29:38,530 --> 00:29:42,310
+detests to socialize. This is a custom, permanent
+
+329
+00:29:42,310 --> 00:29:45,510
+custom with the speaker. I mean, his mood is like
+
+330
+00:29:45,510 --> 00:29:53,570
+this. The suspect confessed murdering the man. We
+
+331
+00:29:53,570 --> 00:29:56,430
+can't say that the subject confessed to murder the
+
+332
+00:29:56,430 --> 00:29:59,230
+man because the action happened.
+
+333
+00:30:02,820 --> 00:30:08,460
+We have Arabic, the Arabic reactive verbs. These
+
+334
+00:30:08,460 --> 00:30:26,700
+are like يثمن يناقش يقدر يقيم يقاوم يتذكر ينسى
+
+335
+00:30:26,700 --> 00:30:32,660
+يتخيل And these verbs, as you see, accept both.
+
+336
+00:30:33,400 --> 00:30:36,980
+Overt derived nominal and covert derived nominal.
+
+337
+00:30:37,580 --> 00:30:40,700
+They accept both. However, in English, they only
+
+338
+00:30:40,700 --> 00:30:48,180
+accept gerund. قَدَّرَ اللَّهُ أَن يَتِمَّ ذَلِكَ
+
+339
+00:30:48,180 --> 00:30:54,280
+We can say also, قَدَّرَ اللَّهُ أَتْمَامَ ذَلِكَ
+
+340
+00:30:54,280 --> 00:30:57,400
+لَنَ
+
+341
+00:30:57,400 --> 00:31:04,550
+تَسَوَّر أن نقبل الظلم لا نتصور قبول الظلم so we
+
+342
+00:31:04,550 --> 00:31:13,650
+accept here we both are accepted يفضل
+
+343
+00:31:13,650 --> 00:31:18,810
+عليهم أن يرفض
+
+344
+00:31:18,810 --> 00:31:23,390
+عليهم أن يظلم الناس يرفض عليهم ظلم الناس
+
+345
+00:31:29,050 --> 00:31:35,730
+يفترض زيدن أن يجيء عمرن يفترض زيدن ماجيء عمرن
+
+346
+00:31:35,730 --> 00:31:39,170
+يتطلب
+
+347
+00:31:39,170 --> 00:31:48,350
+النجاح الاشتهاد أو أن أشتهد يتطلب النجاح الاشتهاد
+
+348
+00:31:48,350 --> 00:31:51,530
+okay now the derived nominal in Arabic
+
+349
+00:31:51,530 --> 00:31:56,370
+syntactically works as a verb it assigns case
+
+350
+00:31:57,790 --> 00:32:02,890
+Mostly it assigns genitive case. It has the
+
+351
+00:32:02,890 --> 00:32:05,870
+requirements of a verb. You know, the verb assigns
+
+352
+00:32:05,870 --> 00:32:12,710
+accusative case. كتب زيدن الدرسة. الدرسة is an
+
+353
+00:32:12,710 --> 00:32:16,330
+object. John wrote the lesson. The lesson is an
+
+354
+00:32:16,330 --> 00:32:23,430
+object assigned accusative case. Okay? Now يفضل
+
+355
+00:32:23,430 --> 00:32:32,260
+زيدن كتابة الدرسي. الدرسي is an object but here it
+
+356
+00:32:32,260 --> 00:32:35,940
+is we have the genitive case assigned to this noun
+
+357
+00:32:35,940 --> 00:32:40,120
+this directly comes from the derived nominal the
+
+358
+00:32:40,120 --> 00:32:48,820
+overt derived nominal okay we
+
+359
+00:32:48,820 --> 00:32:51,360
+have some reactive verbs in Arabic only accept
+
+360
+00:32:51,360 --> 00:32:57,760
+nouns not derived nominal like لا يثمن تعب
+
+361
+00:32:57,760 --> 00:33:04,900
+الوالدين بالنقود. Ta'ab is referred to as a noun
+
+362
+00:33:04,900 --> 00:33:13,080
+in Arabic. لا يثمن أن يتعب الوالدين بالنقود. This
+
+363
+00:33:13,080 --> 00:33:16,660
+is not accepted. In case of having a noun coming
+
+364
+00:33:16,660 --> 00:33:22,880
+after the reactive verb, then we have only the
+
+365
+00:33:22,880 --> 00:33:24,580
+overt derived nominal accepted.
+
+366
+00:33:30,650 --> 00:33:39,410
+Okay? يقاوم الجنود هجوم العدو يقاوم الجنود أن يهجم
+
+367
+00:33:39,410 --> 00:33:39,870
+العدو يقاوم الجنود أن يهجم العدو يقاوم الجنود أن
+
+368
+00:33:39,870 --> 00:33:44,370
+يهجم العدو يقاوم الجنود أن يهجم العدو يقاوم الجنود
+
+369
+00:33:44,370 --> 00:33:45,370
+أن يهجم العدو يقاوم الجنود أن يهجم العدو يقاوم
+
+370
+00:33:45,370 --> 00:33:48,090
+الجنود أن يهجم العدو يقاوم الجنود أن يهجم العدو
+
+371
+00:33:48,090 --> 00:33:48,490
+يقاوم الجنود أن يهجم العدو يقاوم الجنود أن يهجم
+
+372
+00:33:48,490 --> 00:33:50,850
+يهجم العدو يقاوم الجنود أن يهجم العدو يقاوم الجنود
+
+373
+00:33:50,850 --> 00:33:56,150
+أن يهجم العد not a noun following the reactive
+
+374
+00:33:56,150 --> 00:34:00,890
+verb then we have both derived nominal overt and
+
+375
+00:34:00,890 --> 00:34:03,170
+covert or modified derived nominal.
+
+376
+00:34:05,850 --> 00:34:10,710
+We have the last category that is forward oriented
+
+377
+00:34:10,710 --> 00:34:11,190
+verbs.
+
+378
+00:34:14,020 --> 00:34:17,200
+These verbs refer to theoretical actions to
+
+379
+00:34:17,200 --> 00:34:22,060
+hypothetical actions to actions that will be
+
+380
+00:34:22,060 --> 00:34:29,860
+fulfilled in future Okay So
+
+381
+00:34:29,860 --> 00:34:34,780
+all the verbs here are hypothetical and they
+
+382
+00:34:34,780 --> 00:34:41,280
+accept only infinitive Okay,
+
+383
+00:34:41,760 --> 00:34:47,860
+we expected to stop the security disorder soon.
+
+384
+00:34:48,660 --> 00:34:56,700
+Expect, hope, imagine. Okay? These verbs refer to
+
+385
+00:34:56,700 --> 00:35:03,320
+action that is to happen. Okay? We expect to stop
+
+386
+00:35:03,320 --> 00:35:06,080
+the security disorder. We cannot say we expect
+
+387
+00:35:06,080 --> 00:35:12,320
+stopping. We hope to submit the paper soon. We
+
+388
+00:35:12,320 --> 00:35:16,880
+cannot say, we hope submitting. Okay? Because it
+
+389
+00:35:16,880 --> 00:35:21,200
+refers to action that has not happened. Okay? They
+
+390
+00:35:21,200 --> 00:35:25,140
+planned to spend the vacation in London. We cannot
+
+391
+00:35:25,140 --> 00:35:29,340
+say they planned spending because the action has
+
+392
+00:35:29,340 --> 00:35:30,160
+not happened yet.
+
+393
+00:35:35,860 --> 00:35:39,900
+Mary aspired to be a famous advocate.
+
+394
+00:35:42,350 --> 00:35:46,110
+تتصور أنها ستكون. We speak about things which have
+
+395
+00:35:46,110 --> 00:35:49,890
+not been happened. So, the verbs like these are
+
+396
+00:35:49,890 --> 00:35:57,890
+like Britain, persuade, urge, tend, tell, order,
+
+397
+00:35:58,490 --> 00:36:04,750
+learn, aspire, ask, force, fear, decline, agree,
+
+398
+00:36:05,770 --> 00:36:12,230
+we have managed, Long seek, remind, refuse, swear,
+
+399
+00:36:13,670 --> 00:36:19,850
+mean, offer, strive, and vow. Okay? Of course, we
+
+400
+00:36:19,850 --> 00:36:29,070
+have hope as well. Own and expect. Okay? Ahmed was
+
+401
+00:36:29,070 --> 00:36:34,730
+obliged to attend the
+
+402
+00:36:34,730 --> 00:36:35,050
+meeting.
+
+403
+00:36:43,200 --> 00:36:47,880
+The suspect abstained to answer the detective's
+
+404
+00:36:47,880 --> 00:36:52,480
+questions. The action has not happened.
+
+405
+00:36:56,220 --> 00:37:00,200
+Now, if you look to Arabic, we also have forward
+
+406
+00:37:00,200 --> 00:37:06,460
+-oriented verbs. Okay? They accept both modified
+
+407
+00:37:06,460 --> 00:37:15,040
+and overt derived nominal. يتوقع يعني expect يخطط
+
+408
+00:37:15,040 --> 00:37:24,200
+يريد ينوي يصمم These verbs are forward oriental
+
+409
+00:37:24,200 --> 00:37:28,400
+verbs. They still have the meaning that has not
+
+410
+00:37:28,400 --> 00:37:30,420
+been fulfilled.
+
+411
+00:37:33,660 --> 00:37:43,040
+So يتوقع زيدن أن يصل أخاه من السفر اليوم أن يصل
+
+412
+00:37:44,570 --> 00:37:48,030
+يتوقع زيدون وصول أخيه من السفر اليوم يتوقع زيدون
+
+413
+00:37:48,030 --> 00:37:51,510
+وصول أخيه من السفر اليوم So they have both forward
+
+414
+00:37:51,510 --> 00:37:56,530
+oriented verbs except both overt and covert
+
+415
+00:37:56,530 --> 00:37:58,690
+derived nominal however in English once you
+
+416
+00:37:58,690 --> 00:38:06,030
+translate you only have infinitive okay so we have
+
+417
+00:38:06,030 --> 00:38:11,450
+here a point of dissimilarity between Arabic and
+
+418
+00:38:11,450 --> 00:38:18,080
+English He intends for the sinner to repent to God
+
+419
+00:38:18,080 --> 00:38:26,960
+He intends for the sinner to repent to God Zayd
+
+420
+00:38:26,960 --> 00:38:31,560
+suggests that he meet a Indian He suggests that
+
+421
+00:38:31,560 --> 00:38:36,220
+Zayd meet an Indian The father plans
+
+422
+00:38:48,660 --> 00:38:49,980
+Okay,
+
+423
+00:39:01,480 --> 00:39:06,550
+we have both infinitive and gerund okay sorry we
+
+424
+00:39:06,550 --> 00:39:11,330
+have both overt derived nominal and covert derived
+
+425
+00:39:11,330 --> 00:39:18,550
+nominal you see so this shows that Arabic here is
+
+426
+00:39:18,550 --> 00:39:24,290
+different from English regarding the use of overt
+
+427
+00:39:24,290 --> 00:39:27,550
+and covert derived nominal their equivalents in
+
+428
+00:39:27,550 --> 00:39:31,370
+English are gerund and infinitive however not
+
+429
+00:39:31,370 --> 00:39:37,510
+necessarily We have the same translation. So once
+
+430
+00:39:37,510 --> 00:39:43,590
+we have a sentence involving infinitive, it's not
+
+431
+00:39:43,590 --> 00:39:47,570
+necessarily to be translated into covert derived
+
+432
+00:39:47,570 --> 00:39:51,490
+nominal. And once we have a sentence involving
+
+433
+00:39:51,490 --> 00:39:55,050
+overt derived nominal, it's not necessarily to be
+
+434
+00:39:55,050 --> 00:39:58,650
+translated into gerund. You have to take care. We
+
+435
+00:39:58,650 --> 00:40:03,010
+have four categories. You have to understand them
+
+436
+00:40:03,010 --> 00:40:08,110
+very, very carefully in order to facilitate your
+
+437
+00:40:08,110 --> 00:40:11,030
+translation and you come out with correct
+
+438
+00:40:11,030 --> 00:40:14,050
+translation at the end of the day. So we have four
+
+439
+00:40:14,050 --> 00:40:17,410
+categories. We speak about emotive verbs,
+
+440
+00:40:17,870 --> 00:40:21,350
+aspectual verbs, reactive verbs, and forward
+
+441
+00:40:21,350 --> 00:40:27,190
+-oriented verbs. Why do we have these verbs of
+
+442
+00:40:27,190 --> 00:40:31,950
+different semantic functions, different syntactic
+
+443
+00:40:31,950 --> 00:40:36,410
+functions? Sometimes we use both infinitive and
+
+444
+00:40:36,410 --> 00:40:39,850
+gerund, sometimes we have only gerund and some
+
+445
+00:40:39,850 --> 00:40:46,010
+other times we have only infinitive. This relies
+
+446
+00:40:46,010 --> 00:40:51,200
+on the lexical entry of the verb. the lexical
+
+447
+00:40:51,200 --> 00:40:53,860
+entry of the verb, the lexical capacity of the
+
+448
+00:40:53,860 --> 00:40:59,480
+verb. Okay? So it either accepts infinitive, it
+
+449
+00:40:59,480 --> 00:41:04,380
+either accepts gerund, it may accept both. Okay?
+
+450
+00:41:04,840 --> 00:41:09,960
+So it depends on the lexical capacity. Completely
+
+451
+00:41:09,960 --> 00:41:12,900
+like the verbs of giving once accepting double
+
+452
+00:41:12,900 --> 00:41:18,990
+object construction. John gave Mary a book. john
+
+453
+00:41:18,990 --> 00:41:21,430
+gave a book to mary so we have double object
+
+454
+00:41:21,430 --> 00:41:29,350
+construction and we have dative construction okay
+
+455
+00:41:29,350 --> 00:41:32,750
+still
+
+456
+00:41:32,750 --> 00:41:36,090
+we have one object the direct object plus the
+
+457
+00:41:36,090 --> 00:41:41,220
+dative object john gave a book to mary okay so we
+
+458
+00:41:41,220 --> 00:41:44,280
+have this verb the verbs of giving alternate
+
+459
+00:41:44,280 --> 00:41:47,900
+between double object construction and dative here
+
+460
+00:41:47,900 --> 00:41:51,580
+we have these verbs some of them alternate between
+
+461
+00:41:51,580 --> 00:41:55,160
+accepting overt derived nominal in Arabic or
+
+462
+00:41:55,160 --> 00:42:00,620
+covert derived nominal or gerund or infinitive or
+
+463
+00:42:00,620 --> 00:42:07,360
+both this is attributed to the lexical entry of
+
+464
+00:42:07,360 --> 00:42:11,490
+the verb Okay, the semantic capacity as well can
+
+465
+00:42:11,490 --> 00:42:14,990
+be considered. Okay, that's it for today. Thank
+
+466
+00:42:14,990 --> 00:42:15,130
+you.
+
diff --git a/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/H5hSvmaprtU_raw.srt b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/H5hSvmaprtU_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..d57c4579e67b731bf731fcfea91609f9384e37f9
--- /dev/null
+++ b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/H5hSvmaprtU_raw.srt
@@ -0,0 +1,692 @@
+1
+00:00:13,280 --> 00:00:16,540
+Bismillah ar-Rahman ar-Rahim Last time we spoke
+
+2
+00:00:16,540 --> 00:00:20,360
+about the adverbs and we mentioned that the
+
+3
+00:00:20,360 --> 00:00:26,320
+adverbs as usually modify three elements in
+
+4
+00:00:26,320 --> 00:00:28,460
+language they modify
+
+5
+00:00:32,830 --> 00:00:38,290
+Verb, adjective and another adverb as we said most
+
+6
+00:00:38,290 --> 00:00:42,970
+of the adverbs end in ly except we have some
+
+7
+00:00:42,970 --> 00:00:47,550
+exceptions like I mean adjectives ending in ly
+
+8
+00:00:47,550 --> 00:00:51,870
+like what lovely, lowly, motherly, friendly,
+
+9
+00:00:52,470 --> 00:00:58,900
+neighborly, etc okay the adverbials can be
+
+10
+00:00:58,900 --> 00:01:02,680
+preposition phrases, can be infinitive phrases,
+
+11
+00:01:03,420 --> 00:01:07,580
+okay, and can be also noun phrases. He went to the
+
+12
+00:01:07,580 --> 00:01:11,040
+movies. To the movies is an adverbial phrase
+
+13
+00:01:11,040 --> 00:01:16,260
+consisting of preposition phrase. They lived in
+
+14
+00:01:16,260 --> 00:01:18,440
+Canada during the war. The same thing.
+
+15
+00:01:26,630 --> 00:01:29,250
+For the comparisons of adverbs, as we mentioned
+
+16
+00:01:29,250 --> 00:01:32,170
+last time, we have the same system like
+
+17
+00:01:32,170 --> 00:01:34,910
+adjectives. So you have three degrees. What are
+
+18
+00:01:34,910 --> 00:01:37,310
+they? What are they?
+
+19
+00:01:40,370 --> 00:01:43,790
+Positive degree,
+
+20
+00:01:44,290 --> 00:01:51,230
+comparative degree, superlative degree. Okay. So
+
+21
+00:01:51,230 --> 00:01:55,440
+we have wukfa, astardices. Comparative. Fastest.
+
+22
+00:01:56,460 --> 00:02:01,280
+Superlative. As fast as... Equality. Positive
+
+23
+00:02:01,280 --> 00:02:06,480
+degree. Okay? Now, the position of the adverb can
+
+24
+00:02:06,480 --> 00:02:10,700
+be sentenced finally, or can come initially, and
+
+25
+00:02:10,700 --> 00:02:13,780
+in that sense, the meaning changes. He arrived
+
+26
+00:02:13,780 --> 00:02:17,140
+late. Lately, he could not seem to be on time for
+
+27
+00:02:17,140 --> 00:02:20,620
+anything. Okay? So, the meaning differs between
+
+28
+00:02:20,620 --> 00:02:24,250
+the two sentences. Okay? I mean the meaning of the
+
+29
+00:02:24,250 --> 00:02:25,090
+adverb late.
+
+30
+00:02:27,830 --> 00:02:30,930
+We mentioned that we have different types of
+
+31
+00:02:30,930 --> 00:02:34,870
+adverbs. We have three main types. They are the
+
+32
+00:02:34,870 --> 00:02:40,530
+adjuncts, disjuncts, and conjuncts. Adjuncts,
+
+33
+00:02:40,830 --> 00:02:44,710
+disjuncts, and conjuncts. Okay? The adjuncts are
+
+34
+00:02:44,710 --> 00:02:46,790
+of different types. We have the intensifiers,
+
+35
+00:02:47,270 --> 00:02:51,380
+which are of three types. They are Emphasizers
+
+36
+00:02:51,380 --> 00:02:56,780
+amplifiers and downtrodes Okay, this is what
+
+37
+00:02:56,780 --> 00:02:59,160
+explained last time, okay?
+
+38
+00:03:02,580 --> 00:03:07,940
+The adverb can post modify and pre modify another
+
+39
+00:03:07,940 --> 00:03:13,100
+adverb or adjective Okay
+
+40
+00:03:13,100 --> 00:03:18,410
+for the adverbs Semantically, we have different
+
+41
+00:03:18,410 --> 00:03:20,810
+types for the adverbs. We have adverbs of manner,
+
+42
+00:03:21,590 --> 00:03:25,410
+adverbs of place, of frequency, of time, and
+
+43
+00:03:25,410 --> 00:03:30,030
+purpose as well. And these were already explained
+
+44
+00:03:30,030 --> 00:03:33,050
+also last time. For the position of the adverb, I
+
+45
+00:03:33,050 --> 00:03:36,160
+told you that it is floating. mainly the adverbs
+
+46
+00:03:36,160 --> 00:03:38,460
+of manner, can be in the beginning of the
+
+47
+00:03:38,460 --> 00:03:42,660
+sentence, in the middle of the sentence, or at the
+
+48
+00:03:42,660 --> 00:03:46,020
+end of the sentence. Okay? Solemnly, the minister
+
+49
+00:03:46,020 --> 00:03:49,200
+addressed her congregation. The minister solemnly
+
+50
+00:03:49,200 --> 00:03:52,220
+addressed her congregation. The minister addressed
+
+51
+00:03:52,220 --> 00:03:54,940
+her congregation solemnly. So, at the beginning,
+
+52
+00:03:55,580 --> 00:04:02,060
+in the middle, at the end. Okay? Now, the position
+
+53
+00:04:02,060 --> 00:04:06,320
+of the adverb. it directly precedes the lexical
+
+54
+00:04:06,320 --> 00:04:12,340
+verb in the sentence. Okay? Or it can come between
+
+55
+00:04:12,340 --> 00:04:15,720
+the auxiliary verb and the lexical verb.
+
+56
+00:04:19,660 --> 00:04:23,060
+For the order of adverbs, we mentioned that the
+
+57
+00:04:23,060 --> 00:04:26,160
+most consistent order of adverbs in the sentence
+
+58
+00:04:26,160 --> 00:04:32,380
+begins with manner, place, frequency, time, and
+
+59
+00:04:32,380 --> 00:04:37,050
+purpose. okay and we cited lots of examples last
+
+60
+00:04:37,050 --> 00:04:44,810
+time okay we have what's called focus where the
+
+61
+00:04:44,810 --> 00:04:47,530
+adverb can moves to the beginning of the sentence
+
+62
+00:04:47,530 --> 00:04:53,790
+okay we have if we have two adverbs at that sense
+
+63
+00:04:53,790 --> 00:04:58,210
+we can start with a shorter one As we cited the
+
+64
+00:04:58,210 --> 00:05:02,290
+examples last time, dad takes a brisk walk before
+
+65
+00:05:02,290 --> 00:05:05,950
+breakfast every day of his life. So before
+
+66
+00:05:05,950 --> 00:05:12,150
+breakfast comes initially or comes first, as you
+
+67
+00:05:12,150 --> 00:05:16,230
+see, because shorter than the second adverb
+
+68
+00:05:16,230 --> 00:05:20,200
+morphologically. Okay? This is what is called
+
+69
+00:05:20,200 --> 00:05:24,780
+focus. Slowly, ever so carefully, Jesse filled the
+
+70
+00:05:24,780 --> 00:05:28,220
+coffee cup up to the brim, even above the brim.
+
+71
+00:05:28,840 --> 00:05:33,000
+Okay? Here you have the sentence, the adverb comes
+
+72
+00:05:33,000 --> 00:05:39,420
+sentence initially for purpose of focus or
+
+73
+00:05:39,420 --> 00:05:45,120
+emphasis. Occasionally, but only occasionally, one
+
+74
+00:05:45,120 --> 00:05:49,700
+of these lemons will get by the inspectors. Okay?
+
+75
+00:05:51,920 --> 00:05:54,740
+As we mentioned syntactically at the beginning of
+
+76
+00:05:54,740 --> 00:05:57,760
+the class last time, we have syntactically three
+
+77
+00:05:57,760 --> 00:06:02,260
+types of adverbials, adjuncts, disjuncts, and
+
+78
+00:06:02,260 --> 00:06:05,420
+conjuncts. And we mentioned that the adjunct is
+
+79
+00:06:05,420 --> 00:06:09,280
+one of the main parts of the body of the sentence.
+
+80
+00:06:09,940 --> 00:06:13,580
+It's not separated from the sentence even by a
+
+81
+00:06:13,580 --> 00:06:18,280
+comma. Okay? Still, the disjunct is directly
+
+82
+00:06:18,280 --> 00:06:22,380
+followed by a comma and begins in the beginning of
+
+83
+00:06:22,380 --> 00:06:25,980
+the sentence okay so it starts sentence initially
+
+84
+00:06:27,180 --> 00:06:31,240
+However, the conjunct means the conjunction. Okay?
+
+85
+00:06:31,560 --> 00:06:34,400
+The connector, the coordinator. Okay? That
+
+86
+00:06:34,400 --> 00:06:37,220
+connects between the parts of the sentence.
+
+87
+00:06:37,700 --> 00:06:42,080
+Frankly, Martha, I don't give a hoot. Fortunately,
+
+88
+00:06:42,240 --> 00:06:45,660
+no one was hurt. So frankly, fortunately, these
+
+89
+00:06:45,660 --> 00:06:47,640
+are disjuncts.
+
+90
+00:06:49,060 --> 00:06:54,140
+Okay? Once we speak about them, nevertheless,
+
+91
+00:06:54,440 --> 00:06:58,280
+however, yet, these are conjuncts. Strictly
+
+92
+00:06:58,280 --> 00:07:03,440
+speaking. The prisoners or our captors released
+
+93
+00:07:03,440 --> 00:07:07,780
+yesterday was very, very nice. So, strictly
+
+94
+00:07:07,780 --> 00:07:12,800
+speaking. Disjunct. Geographically speaking.
+
+95
+00:07:14,640 --> 00:07:16,400
+Disjunct. Okay?
+
+96
+00:07:21,750 --> 00:07:26,870
+Now, we have what is called a viewpoint adjunct.
+
+97
+00:07:27,970 --> 00:07:33,130
+Okay? The viewpoint adjunct is an adverb. It's
+
+98
+00:07:33,130 --> 00:07:38,450
+part of the sentence and it comes finally. It
+
+99
+00:07:38,450 --> 00:07:42,670
+normally locates finally in the sentence. A
+
+100
+00:07:42,670 --> 00:07:45,910
+successful athletic team is often a good team
+
+101
+00:07:45,910 --> 00:07:51,570
+scholastically. Okay? Investing all our money in
+
+102
+00:07:51,570 --> 00:07:56,110
+snowmobiles was probably not a sound idea
+
+103
+00:07:56,110 --> 00:08:00,770
+financially. So financially, scholastically, our
+
+104
+00:08:00,770 --> 00:08:04,370
+viewpoint adverse. Okay? That come sentence
+
+105
+00:08:04,370 --> 00:08:07,210
+finally, and they are considered part of the
+
+106
+00:08:07,210 --> 00:08:10,850
+sentence as well. Okay? And they consist a crucial
+
+107
+00:08:10,850 --> 00:08:13,870
+part of the body of the sentence. So they are not
+
+108
+00:08:13,870 --> 00:08:16,680
+separated by any command. Okay, we explained that
+
+109
+00:08:16,680 --> 00:08:17,540
+last time, I think.
+
+110
+00:08:22,880 --> 00:08:25,940
+We explained that, and I think we terminated on
+
+111
+00:08:25,940 --> 00:08:33,100
+this. Title, focus, and negative adverbs. Okay?
+
+112
+00:08:34,860 --> 00:08:37,440
+Semantically, we have negative adverbs that do not
+
+113
+00:08:37,440 --> 00:08:42,120
+need the particle not. Like seldom, hardly,
+
+114
+00:08:42,780 --> 00:08:49,040
+rarely, okay? Never. He has never been much help
+
+115
+00:08:49,040 --> 00:08:54,260
+to his mother. So it is equal to the sentence that
+
+116
+00:08:54,260 --> 00:09:00,860
+he has not helped her mother at all, for example.
+
+117
+00:09:01,620 --> 00:09:07,640
+Okay? She has not helped her mother. So the never
+
+118
+00:09:07,640 --> 00:09:12,600
+adverb, never adverb equals the particle not. So
+
+119
+00:09:12,600 --> 00:09:16,200
+there is no need for having double negative in the
+
+120
+00:09:16,200 --> 00:09:19,100
+sentence. We cannot say he hasn't never been.
+
+121
+00:09:21,140 --> 00:09:24,860
+Okay? Double negative is not available in English.
+
+122
+00:09:27,740 --> 00:09:28,500
+Yes.
+
+123
+00:09:31,880 --> 00:09:36,080
+No, no. Double negative. It may be available in
+
+124
+00:09:36,080 --> 00:09:39,760
+some English
+
+125
+00:09:39,760 --> 00:09:44,420
+dialects, okay? Like Arabic. For standard Arabic,
+
+126
+00:09:44,580 --> 00:09:50,560
+we don't have double negative. لا يدرس، لا يأتي،
+
+127
+00:09:50,560 --> 00:09:54,540
+لا يريد. But in Palestinian Arabic, we have double
+
+128
+00:09:54,540 --> 00:10:00,600
+negative. ما بدّيش، ما ش. Okay? Double negative.
+
+129
+00:10:00,840 --> 00:10:08,300
+ما بدّيش. Okay? So we have this double negative
+
+130
+00:10:08,300 --> 00:10:12,300
+available in dialects of Arabic and may available
+
+131
+00:10:12,300 --> 00:10:15,780
+in some dialects of English, but not necessarily
+
+132
+00:10:15,780 --> 00:10:19,160
+in received English or standard English or even
+
+133
+00:10:19,160 --> 00:10:24,200
+standard Arabic. He's never been much help to his
+
+134
+00:10:24,200 --> 00:10:28,840
+mother. He seldom visits. She hardly eats anything
+
+135
+00:10:28,840 --> 00:10:32,040
+since the accident. After his long and tedious
+
+136
+00:10:32,040 --> 00:10:35,300
+lectures, rarely was anyone awake.
+
+137
+00:10:38,180 --> 00:10:48,760
+Okay? So, for Arabic, we have adverbs which are
+
+138
+00:10:48,760 --> 00:10:52,500
+called hal. They are represented in Arabic
+
+139
+00:10:52,500 --> 00:10:56,220
+syntactically by using the preposition phrase and
+
+140
+00:10:56,220 --> 00:11:03,660
+the derived nominal okay ذهبت إلى الجامعة بسرعة
+
+141
+00:11:03,660 --> 00:11:14,000
+ذهبت إلى الجامعة مصريا بسرعة is had consisting of
+
+142
+00:11:14,000 --> 00:11:19,570
+preposition phrase جار و مجروروشبه الجملة في محال
+
+143
+00:11:19,570 --> 00:11:26,290
+نصب حال مصلى عن حال منصوب بالفتحة So we have this
+
+144
+00:11:26,290 --> 00:11:34,150
+however the construction the syntactic function is
+
+145
+00:11:34,150 --> 00:11:39,850
+the same but I mean the syntactic rules of adverbs
+
+146
+00:11:39,850 --> 00:11:43,630
+in Arabic differ from their syntactic rules in
+
+147
+00:11:43,630 --> 00:11:46,970
+English you have systematic order for the adverbs
+
+148
+00:11:48,630 --> 00:11:53,230
+in English, okay? We have systematic position or
+
+149
+00:11:53,230 --> 00:11:56,150
+strict position of the adverb in English.
+
+150
+00:11:58,730 --> 00:12:02,770
+However, in Arabic, the situation is very simple,
+
+151
+00:12:03,630 --> 00:12:08,170
+very clear. It comes generally at sentence final
+
+152
+00:12:08,170 --> 00:12:14,250
+position. The structure of Arabic adverbs differs
+
+153
+00:12:14,250 --> 00:12:21,390
+from English, okay? So this causes what was called
+
+154
+00:12:21,390 --> 00:12:25,530
+interlingual errors and some interlingual errors
+
+155
+00:12:25,530 --> 00:12:28,830
+that come as a result of the difficulty of the
+
+156
+00:12:28,830 --> 00:12:33,430
+structure of English adverbs. So we have
+
+157
+00:12:33,430 --> 00:12:37,130
+interlingual errors resulting from the difference
+
+158
+00:12:37,130 --> 00:12:42,120
+in the syntax of adverbs. and the semantics of
+
+159
+00:12:42,120 --> 00:12:45,400
+adverbs, the meaning of the adverb, and the
+
+160
+00:12:45,400 --> 00:12:48,680
+movement. Once we speak about the syntax and the
+
+161
+00:12:48,680 --> 00:12:52,380
+position of the adverb, the movement of the adverb
+
+162
+00:12:52,380 --> 00:12:55,400
+in the sentence, the order of the adverbs within
+
+163
+00:12:55,400 --> 00:13:01,380
+the same sentence. Okay? Now, the meaning can
+
+164
+00:13:01,380 --> 00:13:06,310
+differ according to the position of the adverb. So
+
+165
+00:13:06,310 --> 00:13:11,210
+if it locates sentence finally, it gives a meaning
+
+166
+00:13:11,210 --> 00:13:14,670
+that is different from being sentenced initially,
+
+167
+00:13:14,910 --> 00:13:20,590
+like the adverb late, which we explained. You see?
+
+168
+00:13:21,110 --> 00:13:25,790
+So this is what I have about adverbs. And now we
+
+169
+00:13:25,790 --> 00:13:32,040
+come to another subject. Or it is about
+
+170
+00:13:32,040 --> 00:13:38,380
+causativity in English and Arabic. But before
+
+171
+00:13:38,380 --> 00:13:42,620
+that, we need to have this quiz. So we need to
+
+172
+00:13:42,620 --> 00:13:45,400
+terminate here just for having the chance for the
+
+173
+00:13:45,400 --> 00:13:46,380
+quiz. Thank you.
+
diff --git a/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/Nq-CK4O_-MU_raw.srt b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/Nq-CK4O_-MU_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..6c9581d87f4f5168ed1bc5db5f8e3aec94d7dcb6
--- /dev/null
+++ b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/Nq-CK4O_-MU_raw.srt
@@ -0,0 +1,268 @@
+1
+00:00:13,440 --> 00:00:15,740
+Bismillahirrahmanirrahim. Today inshallah I'm
+
+2
+00:00:15,740 --> 00:00:19,400
+going to continue with causative verbs Last time
+
+3
+00:00:19,400 --> 00:00:22,480
+we spoke about the meaning of causatives, the
+
+4
+00:00:22,480 --> 00:00:26,580
+definition of causatives, types of causatives in
+
+5
+00:00:26,580 --> 00:00:30,560
+English, and we've seen that in English we have
+
+6
+00:00:30,560 --> 00:00:36,260
+active causatives and passive causatives. In case
+
+7
+00:00:36,260 --> 00:00:40,920
+of active, the subject and the agent are available
+
+8
+00:00:40,920 --> 00:00:46,080
+in the sentence. In case of passive, the agent is
+
+9
+00:00:46,080 --> 00:00:50,920
+absent and it is replaced by the object okay we
+
+10
+00:00:50,920 --> 00:00:54,400
+have causative verbs which accept only bare
+
+11
+00:00:54,400 --> 00:00:57,600
+infinitive however we have causative verbs which
+
+12
+00:00:57,600 --> 00:01:03,400
+accept to infinitive okay the verbs which accept
+
+13
+00:01:03,400 --> 00:01:12,390
+bare infinitive are yes have let and make and the
+
+14
+00:01:12,390 --> 00:01:15,210
+verb which accept I mean the causative verb which
+
+15
+00:01:15,210 --> 00:01:20,190
+accept both get okay still the rest of causatives
+
+16
+00:01:20,190 --> 00:01:27,530
+accept to infinitive okay يعني infinitive with to
+
+17
+00:01:27,530 --> 00:01:33,770
+okay now
+
+18
+00:01:33,770 --> 00:01:40,180
+this construction I mean the causative verbs is
+
+19
+00:01:40,180 --> 00:01:46,000
+either with bare infinitive or with two infinitive
+
+20
+00:01:46,000 --> 00:01:52,200
+it appears in active appears in passive it means
+
+21
+00:01:52,200 --> 00:02:00,700
+that the causer does something to the cozy okay it
+
+22
+00:02:00,700 --> 00:02:04,520
+means the subject Or the agent is responsible for
+
+23
+00:02:04,520 --> 00:02:11,180
+causing an action done on the object itself. If
+
+24
+00:02:11,180 --> 00:02:15,560
+you look to Arabic, do you have the same
+
+25
+00:02:15,560 --> 00:02:19,240
+constructions? Do we have causative verbs in
+
+26
+00:02:19,240 --> 00:02:23,600
+Arabic? Don't we have causative verbs? We have
+
+27
+00:02:23,600 --> 00:02:26,280
+causative verbs. We have causative verbs in
+
+28
+00:02:26,280 --> 00:02:30,100
+Arabic, but these causative verbs syntactically
+
+29
+00:02:30,100 --> 00:02:32,820
+differ from English and the function of the
+
+30
+00:02:32,820 --> 00:02:36,060
+causative verb in Arabic differs from English.
+
+31
+00:02:36,180 --> 00:02:41,700
+We've seen or we dealt with the infinitive and
+
+32
+00:02:41,700 --> 00:02:47,840
+bare infinitive in English. However, in Arabic, we
+
+33
+00:02:47,840 --> 00:02:52,880
+don't have this equivalence. We have the verb
+
+34
+00:02:52,880 --> 00:02:59,120
+itself has some sort of inflections added to it,
+
+35
+00:02:59,320 --> 00:03:02,440
+so it becomes accusative verb. The first
+
+36
+00:03:02,440 --> 00:03:09,080
+inflection is allowed. Yes, this is by changing
+
+37
+00:03:09,080 --> 00:03:13,700
+the inflection itself, the nominative, the
+
+38
+00:03:13,700 --> 00:03:23,000
+genitive and the accusative case. هزق هزق Okay. So
+
+39
+00:03:23,000 --> 00:03:27,860
+we change the genitive case into accusative case,
+
+40
+00:03:28,200 --> 00:03:32,400
+having the causative there. We still have what is
+
+41
+00:03:32,400 --> 00:03:39,660
+called gemination. Okay. Hadama, haddama. Alima,
+
+42
+00:03:40,700 --> 00:03:47,710
+allama. Okay. You add another Sound having what
+
+43
+00:03:47,710 --> 00:03:50,490
+was called the consonant doubling. This is called
+
+44
+00:03:50,490 --> 00:03:55,710
+gymnasium. Okay shut down Okay, now still we have
+
+45
+00:03:55,710 --> 00:04:01,070
+Another way the third way. This is Hamza Okay, you
+
+46
+00:04:01,070 --> 00:04:05,950
+have the Hamza the glottal sound a Okay when I say
+
+47
+00:04:05,950 --> 00:04:14,710
+for example Farrah Farraha Afraha Okay Alima Alama
+
+48
+00:04:17,900 --> 00:04:28,940
+but not all verbs have these three ways okay don't
+
+49
+00:04:28,940 --> 00:04:33,380
+have all these verbs except the three ways all
+
+50
+00:04:33,380 --> 00:04:38,260
+together for making the verb causative okay we
+
+51
+00:04:38,260 --> 00:04:41,460
+have some verbs except all-determination some
+
+52
+00:04:41,460 --> 00:04:47,170
+other verbs except about another category of verbs
+
+53
+00:04:47,170 --> 00:04:51,610
+except the glottal sound or the glottal sound a or
+
+54
+00:04:51,610 --> 00:04:56,770
+hamza at the beginning of the verb okay but
+
+55
+00:04:56,770 --> 00:04:59,850
+functionally
+
+56
+00:04:59,850 --> 00:05:06,370
+or say syntactically the two verbs i mean english
+
+57
+00:05:06,370 --> 00:05:09,730
+and arabic causatives differ completely from each
+
+58
+00:05:09,730 --> 00:05:15,250
+other okay so This does not cause what is called
+
+59
+00:05:15,250 --> 00:05:18,370
+negative interference once learning causatives.
+
+60
+00:05:19,070 --> 00:05:24,190
+All causative errors or mistakes done by the Arab
+
+61
+00:05:24,190 --> 00:05:30,230
+learners of English result from the difficulty of
+
+62
+00:05:30,230 --> 00:05:33,570
+English that result to what is called intralingual
+
+63
+00:05:33,570 --> 00:05:38,830
+errors. Intralingual errors, okay? That's it for
+
+64
+00:05:38,830 --> 00:05:42,790
+causatives and now we need to discuss the point
+
+65
+00:05:42,790 --> 00:05:46,990
+generally and also need to speak about the best
+
+66
+00:05:46,990 --> 00:05:51,330
+activities or games for teaching causatives to our
+
+67
+00:05:51,330 --> 00:05:52,730
+students. That's it.
+
diff --git a/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/SOlLbIAz1Dk_postprocess.srt b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/SOlLbIAz1Dk_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f762984fd798665a5cf82afbc1bed56592809189
--- /dev/null
+++ b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/SOlLbIAz1Dk_postprocess.srt
@@ -0,0 +1,1708 @@
+1
+00:00:16,140 --> 00:00:19,460
+Today we are going to speak about the prepositions
+
+2
+00:00:19,460 --> 00:00:24,140
+of English and Arabic This is very tricky subject
+
+3
+00:00:24,140 --> 00:00:26,020
+since
+
+4
+00:00:28,310 --> 00:00:33,210
+English has 150 prepositions,
+
+5
+00:00:33,650 --> 00:00:41,770
+150 prepositions, while Arabic has only 20
+
+6
+00:00:41,770 --> 00:00:49,450
+prepositions, six of them are widely used. So
+
+7
+00:00:49,450 --> 00:00:51,610
+there is no equivalence between the prepositions
+
+8
+00:00:51,610 --> 00:00:57,500
+of English and the prepositions of Arabic. The
+
+9
+00:00:57,500 --> 00:01:03,000
+meaning is conveyed straightforwardly in Arabic by
+
+10
+00:01:03,000 --> 00:01:06,440
+using only one preposition. However, the same
+
+11
+00:01:06,440 --> 00:01:08,580
+meaning can be conveyed in a number of
+
+12
+00:01:08,580 --> 00:01:12,920
+prepositions in English. So this causes confusion
+
+13
+00:01:12,920 --> 00:01:20,410
+and makes our students, I mean the Arab students,
+
+14
+00:01:20,590 --> 00:01:24,490
+to commit serious errors in using prepositions.
+
+15
+00:01:25,070 --> 00:01:28,650
+Most of them are interlingual errors. They result
+
+16
+00:01:28,650 --> 00:01:34,610
+from Arabic. The preposition of English has
+
+17
+00:01:34,610 --> 00:01:41,490
+semantic function and syntactic function. Semantic
+
+18
+00:01:41,490 --> 00:01:46,700
+function means it gives a meaning. It refers to
+
+19
+00:01:46,700 --> 00:01:51,980
+place, time, a position, manner, etc.
+
+20
+00:01:54,260 --> 00:01:58,400
+Syntactically, it refers to case assignment.
+
+21
+00:02:00,740 --> 00:02:04,420
+The case I mean nominative, accusative, and
+
+22
+00:02:04,420 --> 00:02:08,720
+genitive case. Mainly the genitive case and the
+
+23
+00:02:08,720 --> 00:02:13,380
+dative case are assigned by prepositions in a
+
+24
+00:02:13,380 --> 00:02:18,980
+certain places a language. So we have, for
+
+25
+00:02:18,980 --> 00:02:24,240
+example, John gave Mary a book. John gave a book
+
+26
+00:02:24,240 --> 00:02:31,100
+to Mary. To Mary, Mary, John here is a subject
+
+27
+00:02:31,100 --> 00:02:37,500
+assigned nominative case, while book is direct
+
+28
+00:02:37,500 --> 00:02:43,640
+object assigned accusative case and to Mary, Mary
+
+29
+00:02:43,640 --> 00:02:48,640
+is prepositional object assigned dative case. The
+
+30
+00:02:48,640 --> 00:02:52,420
+dative case is equivalent to accusative case,
+
+31
+00:02:53,320 --> 00:02:58,060
+fatha, but it is assigned by the preposition, the
+
+32
+00:02:58,060 --> 00:03:02,420
+dative preposition too. At the same time, we have
+
+33
+00:03:02,420 --> 00:03:06,400
+our other prepositions assigned genitive case,
+
+34
+00:03:07,440 --> 00:03:13,520
+completely like Arabic, kasra. So we have He
+
+35
+00:03:13,520 --> 00:03:16,980
+arrived in London. This means he dominantly lives
+
+36
+00:03:16,980 --> 00:03:22,800
+or stays in London. He arrives in London is
+
+37
+00:03:22,800 --> 00:03:28,540
+different from he arrives at London. Okay? At
+
+38
+00:03:28,540 --> 00:03:34,080
+London means transitional arrival. However, in
+
+39
+00:03:34,080 --> 00:03:38,940
+London means dominant stay
+
+40
+00:03:38,940 --> 00:03:43,930
+in London. Okay, here he arrived in London or at
+
+41
+00:03:43,930 --> 00:03:49,850
+London, the prepositional noun London is assigned
+
+42
+00:03:49,850 --> 00:03:55,970
+genitive case by the prepositions at or in. Most
+
+43
+00:03:55,970 --> 00:03:58,750
+of the prepositions assign genitive case except
+
+44
+00:03:58,750 --> 00:04:04,090
+the dative preposition to, which assigns dative
+
+45
+00:04:04,090 --> 00:04:08,410
+case, which is equivalent to accusative case.
+
+46
+00:04:09,970 --> 00:04:16,220
+Okay. Semantically, we see that the prepositions
+
+47
+00:04:16,220 --> 00:04:21,100
+are of different semantic functions. We have
+
+48
+00:04:21,100 --> 00:04:27,320
+prepositions of time. So we have in, at, on,
+
+49
+00:04:28,660 --> 00:04:36,520
+after, before, etc. Now in is related to, it
+
+50
+00:04:36,520 --> 00:04:45,240
+precedes months, years, seasons, and parts of the
+
+51
+00:04:45,240 --> 00:04:50,300
+day. So we have in months, we say in July, in
+
+52
+00:04:50,300 --> 00:04:56,580
+September. For years, we say in 1985, 1999.
+
+53
+00:04:58,160 --> 00:05:04,800
+Seasons, we say in summer, in the summer of 1969,
+
+54
+00:05:05,300 --> 00:05:10,660
+for example. We say in the morning, in the
+
+55
+00:05:10,660 --> 00:05:15,900
+afternoon, in the evening. But if you speak about
+
+56
+00:05:15,900 --> 00:05:20,060
+very, very specific time, we use at. I say at
+
+57
+00:05:20,060 --> 00:05:28,780
+noon, at dawn, at sunset. I mean the moment which
+
+58
+00:05:28,780 --> 00:05:36,260
+refers to the existence of dawn, noon, or sunset.
+
+59
+00:05:37,820 --> 00:05:41,340
+However, if you speak about long duration, you say
+
+60
+00:05:41,340 --> 00:05:44,360
+in the morning, in the afternoon, in the evening.
+
+61
+00:05:46,640 --> 00:05:51,680
+Okay? Also durations we see in, I say in a minute,
+
+62
+00:05:52,240 --> 00:06:00,180
+in two weeks, in an hour, in a day, in a month, in
+
+63
+00:06:00,180 --> 00:06:09,350
+15 days. This is duration. However, at refers to
+
+64
+00:06:09,350 --> 00:06:15,670
+part of the day, as in we say at night, at six o
+
+65
+00:06:15,670 --> 00:06:19,170
+'clock, at midnight. We speak about time, not
+
+66
+00:06:19,170 --> 00:06:26,290
+duration. Also, we refer to celebrations by using
+
+67
+00:06:26,290 --> 00:06:32,030
+at. At Christmas, at Easter, at Ramadan feast,
+
+68
+00:06:32,830 --> 00:06:33,150
+etc.
+
+69
+00:06:36,780 --> 00:06:40,020
+If you speak about fixed phrases, we use also at.
+
+70
+00:06:40,900 --> 00:06:44,100
+So we say at the same time, not in the same time,
+
+71
+00:06:44,600 --> 00:06:45,840
+at the same time.
+
+72
+00:06:49,540 --> 00:06:55,660
+On refers to the days. Days of the week take on.
+
+73
+00:06:57,900 --> 00:07:02,080
+Dates of the days also take on. I say on Sunday,
+
+74
+00:07:02,560 --> 00:07:10,020
+on Friday, on 25th of December. The date and days
+
+75
+00:07:10,020 --> 00:07:15,480
+of the week receive on. Special holidays, we say
+
+76
+00:07:15,480 --> 00:07:20,280
+on Good Friday, on Easter Sunday, on my birthday.
+
+77
+00:07:20,880 --> 00:07:26,860
+We mean the day. Okay? If you speak about special,
+
+78
+00:07:27,000 --> 00:07:30,140
+very special part of the day, I say on the morning
+
+79
+00:07:30,140 --> 00:07:35,160
+of September. So this is specific, not generic.
+
+80
+00:07:35,980 --> 00:07:41,110
+Okay? on the morning of September. We see in the
+
+81
+00:07:41,110 --> 00:07:45,830
+morning. Which morning? In the afternoon. In the
+
+82
+00:07:45,830 --> 00:07:49,830
+evening. This is generic. However, speaking
+
+83
+00:07:49,830 --> 00:07:54,690
+specifically about one special morning becomes on.
+
+84
+00:07:56,290 --> 00:08:01,150
+Okay, you see? On the morning of September the
+
+85
+00:08:01,150 --> 00:08:11,100
+11th. After refers also to time. I say, after
+
+86
+00:08:11,100 --> 00:08:15,620
+something happened, later than something happened,
+
+87
+00:08:16,020 --> 00:08:17,040
+after school,
+
+88
+00:08:20,040 --> 00:08:21,080
+after lecture,
+
+89
+00:08:24,300 --> 00:08:31,700
+after arrival, after the accident. It refers to
+
+90
+00:08:31,700 --> 00:08:36,280
+something happening after another thing. Pay
+
+91
+00:08:36,280 --> 00:08:37,000
+attention, please.
+
+92
+00:08:40,700 --> 00:08:47,000
+Ago. Ago refers to the past. Okay? So it comes
+
+93
+00:08:47,000 --> 00:08:54,100
+after time. Okay? It refers to how far something
+
+94
+00:08:54,100 --> 00:08:59,080
+happened in the past. Six years ago. Five days
+
+95
+00:08:59,080 --> 00:09:04,700
+ago. Three hours ago. An hour ago. It refers to
+
+96
+00:09:04,700 --> 00:09:11,090
+past. Past simple. Before, it's the opposite of
+
+97
+00:09:11,090 --> 00:09:15,370
+after, but it refers to something that happened
+
+98
+00:09:15,370 --> 00:09:19,370
+earlier than some other things. I say before
+
+99
+00:09:19,370 --> 00:09:24,350
+Christmas, before Ramadan feast, before Al-Adha
+
+100
+00:09:24,350 --> 00:09:33,040
+Eid or feast, okay? Between, it refers also to
+
+101
+00:09:33,040 --> 00:09:38,420
+separate two points. I say between Monday and
+
+102
+00:09:38,420 --> 00:09:43,320
+Friday. So this is a duration of time between.
+
+103
+00:09:45,500 --> 00:09:50,740
+We can use also by referring to time as well. So
+
+104
+00:09:50,740 --> 00:09:55,340
+we say not later than a special time by Thursday.
+
+105
+00:09:56,440 --> 00:10:02,040
+By Thursday. Okay, they are going to finish the
+
+106
+00:10:02,040 --> 00:10:05,820
+project or they will have the project finished by
+
+107
+00:10:05,820 --> 00:10:11,840
+the end of April by the end of April Okay, not
+
+108
+00:10:11,840 --> 00:10:14,820
+later than a special time. Yeah, not not later
+
+109
+00:10:14,820 --> 00:10:21,300
+than the end of April Okay During
+
+110
+00:10:21,300 --> 00:10:26,960
+So it refers to progressive action action will
+
+111
+00:10:26,960 --> 00:10:32,740
+happen during a period of time through the whole
+
+112
+00:10:32,740 --> 00:10:36,440
+period of time. We say, for example, during the
+
+113
+00:10:36,440 --> 00:10:42,880
+holidays, most of us have picnics to the seashore.
+
+114
+00:10:46,480 --> 00:10:46,940
+Okay?
+
+115
+00:10:52,920 --> 00:10:57,940
+During the holidays. For, it refers also to the
+
+116
+00:10:57,940 --> 00:11:04,030
+period of time. for three weeks. This is duration.
+
+117
+00:11:05,110 --> 00:11:13,570
+I stay in Gaza for six months. I have stayed in
+
+118
+00:11:13,570 --> 00:11:17,090
+Gaza for six months. I have stayed in Gaza for
+
+119
+00:11:17,090 --> 00:11:22,250
+five months. I have stayed in Gaza since last
+
+120
+00:11:22,250 --> 00:11:27,050
+April. So for refers to duration. While since
+
+121
+00:11:27,050 --> 00:11:31,930
+refers to time. Okay. They are the key
+
+122
+00:11:31,930 --> 00:11:38,970
+prepositions used with present perfect Okay,
+
+123
+00:11:39,230 --> 00:11:45,910
+so I stay I have stayed for three weeks From to
+
+124
+00:11:45,910 --> 00:11:52,650
+from till until these are our prepositions which
+
+125
+00:11:52,650 --> 00:11:58,420
+are mainly used to refer to time. Two points from
+
+126
+00:11:58,420 --> 00:12:00,980
+a period, from Monday to Wednesday, for example.
+
+127
+00:12:01,500 --> 00:12:05,900
+From two. From Monday till Wednesday. Two is
+
+128
+00:12:05,900 --> 00:12:09,400
+equivalent to till. From Monday until Wednesday.
+
+129
+00:12:09,880 --> 00:12:16,860
+Two till until. They are of the same meaning. They
+
+130
+00:12:16,860 --> 00:12:20,180
+refer to two points from one period to another.
+
+131
+00:12:20,360 --> 00:12:21,660
+From Monday to Wednesday.
+
+132
+00:12:25,590 --> 00:12:33,110
+Okay. Past. Past as a preposition. It refers to
+
+133
+00:12:33,110 --> 00:12:37,330
+time of the day. Twenty-three minutes past six.
+
+134
+00:12:39,450 --> 00:12:50,270
+Okay. Half past six. Okay. So it refers to time,
+
+135
+00:12:51,370 --> 00:12:57,280
+the clock time. Okay. Since refers to point, not
+
+136
+00:12:57,280 --> 00:13:02,780
+duration. Specific point. Okay. Point of time. I
+
+137
+00:13:02,780 --> 00:13:07,060
+say since Monday. I haven't seen them since they
+
+138
+00:13:07,060 --> 00:13:12,060
+traveled to London. I haven't seen him since he
+
+139
+00:13:12,060 --> 00:13:17,020
+traveled to Egypt. The time he traveled. The point
+
+140
+00:13:17,020 --> 00:13:20,720
+of time he traveled. So this is referred to by
+
+141
+00:13:20,720 --> 00:13:24,850
+using since. Okay.
+
+142
+00:13:27,950 --> 00:13:32,570
+Till and until also refer to time. I say till
+
+143
+00:13:32,570 --> 00:13:35,850
+tomorrow, until tomorrow, the same thing.
+
+144
+00:13:40,310 --> 00:13:48,590
+Too, it also refers to time of the day. Okay. So
+
+145
+00:13:48,590 --> 00:13:54,510
+we have twenty three minutes to six. Okay. Here we
+
+146
+00:13:54,510 --> 00:14:04,050
+have to and past past refers to after and to
+
+147
+00:14:04,050 --> 00:14:10,690
+refers to before okay up to and not more than
+
+148
+00:14:10,690 --> 00:14:16,700
+special time up to six hours a day within It's
+
+149
+00:14:16,700 --> 00:14:20,280
+during a period of time, within a day. I will
+
+150
+00:14:20,280 --> 00:14:23,500
+finish the project within a day, within two days,
+
+151
+00:14:24,060 --> 00:14:27,180
+within a month, within a year.
+
+152
+00:14:33,860 --> 00:14:37,780
+These are the propositions of time. So we speak
+
+153
+00:14:37,780 --> 00:14:43,670
+about different propositions, mainly in, on, at,
+
+154
+00:14:43,990 --> 00:14:52,890
+for, since, after, before, till, until, ago, past,
+
+155
+00:14:53,330 --> 00:15:02,590
+to, up to, within, between, during. Okay.
+
+156
+00:15:05,450 --> 00:15:10,290
+These refer to time. Okay. Now, if you translate
+
+157
+00:15:10,290 --> 00:15:14,830
+them into Arabic, We speak about nearly 20
+
+158
+00:15:14,830 --> 00:15:18,630
+prepositions, but if they translated into Arabic,
+
+159
+00:15:18,770 --> 00:15:24,850
+they can be referred to by using Fi, one, or Men,
+
+160
+00:15:25,490 --> 00:15:31,490
+two prepositions only versus 20 prepositions in
+
+161
+00:15:31,490 --> 00:15:35,430
+English. So this faces or this makes difficulty
+
+162
+00:15:35,430 --> 00:15:43,030
+for your students to translate. And you yourself
+
+163
+00:15:43,030 --> 00:15:46,930
+commit serious errors in translation, in the use
+
+164
+00:15:46,930 --> 00:15:52,050
+of prepositions. Which to use? Which to use? On or
+
+165
+00:15:52,050 --> 00:15:53,530
+in or at?
+
+166
+00:15:56,810 --> 00:16:03,570
+Between, for example, or among? So it's quite
+
+167
+00:16:03,570 --> 00:16:07,530
+difficult. You have to understand these
+
+168
+00:16:07,530 --> 00:16:10,610
+prepositions, their semantic function, their
+
+169
+00:16:10,610 --> 00:16:14,870
+lexical function, their syntactic function very
+
+170
+00:16:14,870 --> 00:16:18,150
+perfectly. Okay? And you have to use them
+
+171
+00:16:18,150 --> 00:16:22,690
+contextually. We have the prepositions of place
+
+172
+00:16:22,690 --> 00:16:24,130
+and direction.
+
+173
+00:16:26,950 --> 00:16:34,520
+I traveled from Rafah to Gaza. أسكن في غزة من إلى
+
+174
+00:16:34,520 --> 00:16:40,620
+في Okay, this refers to place in Arabic however in
+
+175
+00:16:40,620 --> 00:16:45,260
+English we have lots of Prepositions as you see
+
+176
+00:16:45,260 --> 00:16:51,260
+let's see We sit in the room now. We are in the
+
+177
+00:16:51,260 --> 00:16:58,960
+room Okay The laptop is on the table Okay
+
+178
+00:17:02,790 --> 00:17:06,810
+Here we have the
+
+179
+00:17:06,810 --> 00:17:14,850
+duster is under the table, on the table, okay? Now
+
+180
+00:17:14,850 --> 00:17:24,390
+it's on the board, on the board, okay? If I put it
+
+181
+00:17:24,390 --> 00:17:31,640
+overhead, it's at top of or in top of sorry in top
+
+182
+00:17:31,640 --> 00:17:39,420
+of okay so we have lots of prepositions of place
+
+183
+00:17:39,420 --> 00:17:44,780
+in English however in Arabic you have at most
+
+184
+00:17:44,780 --> 00:17:48,460
+three prepositions this make is this makes
+
+185
+00:17:48,460 --> 00:17:53,960
+confusion and lead your students to commit serious
+
+186
+00:17:53,960 --> 00:17:57,020
+interlingual errors, not intralingual,
+
+187
+00:17:57,540 --> 00:18:01,040
+interlingual errors. And also we have intralingual
+
+188
+00:18:01,040 --> 00:18:06,040
+errors committed in using prepositions. We sit in
+
+189
+00:18:06,040 --> 00:18:12,740
+the room. I see a house in the picture. You have
+
+190
+00:18:12,740 --> 00:18:16,560
+the picture containing lots of things. including a
+
+191
+00:18:16,560 --> 00:18:20,800
+house. So I see a house in the picture. There are
+
+192
+00:18:20,800 --> 00:18:26,100
+trout in the river. He lives in Paris. I found the
+
+193
+00:18:26,100 --> 00:18:30,660
+picture in the paper. He sits in the corner of the
+
+194
+00:18:30,660 --> 00:18:37,400
+room. The first hand side corner, the second hand
+
+195
+00:18:37,400 --> 00:18:43,100
+side corner, the second right-hand side corner,
+
+196
+00:18:43,780 --> 00:18:47,160
+the first right-hand side corner, the first left
+
+197
+00:18:47,160 --> 00:18:50,980
+-hand side corner, the second left-hand side
+
+198
+00:18:50,980 --> 00:18:55,560
+corner. So in the left-hand side corner, in the
+
+199
+00:18:55,560 --> 00:19:01,500
+right-hand side corner, etc. Okay? He sits in the
+
+200
+00:19:01,500 --> 00:19:06,720
+back of the car. We arrive in Madrid. He gets in
+
+201
+00:19:06,720 --> 00:19:10,660
+the car. We speak about the space inside
+
+202
+00:19:10,660 --> 00:19:16,480
+something. We stay in the room. So the room
+
+203
+00:19:16,480 --> 00:19:20,020
+represents a place, a space, and we sit in this
+
+204
+00:19:20,020 --> 00:19:21,940
+place. So in the room.
+
+205
+00:19:29,660 --> 00:19:35,760
+Ibtihal is going to stand close to the door. She
+
+206
+00:19:35,760 --> 00:19:42,060
+is standing by the door, by the door. If the door
+
+207
+00:19:42,060 --> 00:19:46,100
+is open and she is standing just outside, okay, in
+
+208
+00:19:46,100 --> 00:19:49,640
+the border of the room, we say, Btehal is standing
+
+209
+00:19:49,640 --> 00:19:54,440
+at the room, at the room. This is the place. I met
+
+210
+00:19:54,440 --> 00:19:59,140
+my friend at the hospital. What does it mean? At
+
+211
+00:19:59,140 --> 00:20:03,290
+the gates of the hospital. I met my friend in the
+
+212
+00:20:03,290 --> 00:20:12,490
+hospital inside the hospital Okay So we have lots
+
+213
+00:20:12,490 --> 00:20:16,330
+of prepositions as you see that cover the meaning
+
+214
+00:20:16,330 --> 00:20:21,610
+of في The
+
+215
+00:20:21,610 --> 00:20:26,470
+boys stand in a line It's a big tree in the middle
+
+216
+00:20:26,470 --> 00:20:32,130
+of the garden He is in town I have to stay in bed.
+
+217
+00:20:33,890 --> 00:20:39,270
+You mustn't park your car in front of the school.
+
+218
+00:20:40,790 --> 00:20:42,830
+The robber is in prison now.
+
+219
+00:20:46,950 --> 00:20:51,850
+She sits at the desk. I'm sitting at the desk.
+
+220
+00:20:52,330 --> 00:20:57,890
+Open your books at page 10. The bus stops at Graz.
+
+221
+00:20:58,720 --> 00:21:03,140
+Okay, the bus station, I mean, or the bus stop. I
+
+222
+00:21:03,140 --> 00:21:09,260
+stay at my grandmother's house. I stand at the
+
+223
+00:21:09,260 --> 00:21:14,180
+door. Look at the top of the page. The car stands
+
+224
+00:21:14,180 --> 00:21:18,040
+at the end of the street. Can we meet at the
+
+225
+00:21:18,040 --> 00:21:24,220
+corner of the street? I met John at a party. Pat
+
+226
+00:21:24,220 --> 00:21:28,900
+wasn't at home yesterday. I study economics at
+
+227
+00:21:28,900 --> 00:21:32,380
+university. So we study at the Islamic University
+
+228
+00:21:32,380 --> 00:21:37,260
+of Gaza. We can't say we study in the Islamic
+
+229
+00:21:37,260 --> 00:21:41,640
+University of Gaza. At the Islamic University of
+
+230
+00:21:41,640 --> 00:21:49,100
+Gaza. Okay? It refers to your dominant study
+
+231
+00:21:49,100 --> 00:21:55,360
+in this institution. It is aspectual
+
+232
+00:21:55,360 --> 00:21:59,420
+meaning. It refers to aspectual meaning, not
+
+233
+00:21:59,420 --> 00:22:06,460
+concrete meaning. So I say in the class, we are
+
+234
+00:22:06,460 --> 00:22:10,240
+sitting in the class, okay? We are studying in the
+
+235
+00:22:10,240 --> 00:22:13,740
+class. All the time we study in this class, the
+
+236
+00:22:13,740 --> 00:22:16,420
+whole semester long. You understand?
+
+237
+00:22:22,150 --> 00:22:27,010
+So we study at the class or at the university the
+
+238
+00:22:27,010 --> 00:22:32,550
+whole semester long. We currently are studying
+
+239
+00:22:32,550 --> 00:22:38,790
+comparative linguistics in the class. We speak
+
+240
+00:22:38,790 --> 00:22:48,160
+about now a moment, okay? Specific place. Look at
+
+241
+00:22:48,160 --> 00:22:51,240
+the top of the page. The car stands at the end of
+
+242
+00:22:51,240 --> 00:22:54,740
+the street. I'm a Joan at a party. I study
+
+243
+00:22:54,740 --> 00:22:58,900
+economics at university. The children are at
+
+244
+00:22:58,900 --> 00:23:01,600
+grandmother's house. If you ask me about my
+
+245
+00:23:01,600 --> 00:23:05,720
+children, I say to you that they are staying at
+
+246
+00:23:05,720 --> 00:23:10,750
+home. Okay. So we speak about them. They are in
+
+247
+00:23:10,750 --> 00:23:14,770
+Khan Yunus and we are now in Gaza. Okay. But if
+
+248
+00:23:14,770 --> 00:23:18,350
+you ask me about them while I am at home, I say
+
+249
+00:23:18,350 --> 00:23:26,430
+they are in the home. Okay. He always arrives late
+
+250
+00:23:26,430 --> 00:23:33,270
+at school. At school. This is for learning. You
+
+251
+00:23:33,270 --> 00:23:41,090
+see, I say at school. The map lies on the desk. So
+
+252
+00:23:41,090 --> 00:23:46,470
+in translating the meaning of Fi, we met with lots
+
+253
+00:23:46,470 --> 00:23:52,990
+of prepositions, mainly in and at. Now, on.
+
+254
+00:23:56,270 --> 00:24:03,110
+So the map lies on the desk. The picture is on
+
+255
+00:24:03,110 --> 00:24:08,570
+page 10. The photo hangs on the wall. He lives on
+
+256
+00:24:08,570 --> 00:24:17,570
+a farm. Dresden lies on the river. Okay, on. On
+
+257
+00:24:17,570 --> 00:24:23,230
+also refers to, as you see, on place. We spoke
+
+258
+00:24:23,230 --> 00:24:30,070
+about in. I live in Gaza. She lives in London. You
+
+259
+00:24:30,070 --> 00:24:30,290
+see?
+
+260
+00:24:34,160 --> 00:24:39,440
+I'd like to refer to islands. So what prepositions
+
+261
+00:24:39,440 --> 00:24:46,560
+could I use in places like islands? She lives in
+
+262
+00:24:46,560 --> 00:24:53,500
+or on Cyprus? On Cyprus. Or are all islands take
+
+263
+00:24:53,500 --> 00:25:03,600
+on? She lives on Cyprus. Okay. But I live in Gaza.
+
+264
+00:25:09,490 --> 00:25:15,990
+Okay On a farm We speak about a specific place
+
+265
+00:25:15,990 --> 00:25:20,750
+surrounded by fence. It's like the island Okay, so
+
+266
+00:25:20,750 --> 00:25:25,330
+once you speak we speak about on referring to
+
+267
+00:25:25,330 --> 00:25:30,910
+fields specific areas open areas it refers to
+
+268
+00:25:32,390 --> 00:25:36,590
+islands. So regarding place, we say we live in
+
+269
+00:25:36,590 --> 00:25:41,730
+Cyprus, sorry on Cyprus, but in Gaza, in London,
+
+270
+00:25:42,230 --> 00:25:48,630
+etc. He lives on a farm. Dressed in lies on the
+
+271
+00:25:48,630 --> 00:25:53,150
+river Elbe. Men's clothes are on the second floor.
+
+272
+00:25:53,890 --> 00:26:00,550
+On, not in. He lives on Heligoland. Heligoland.
+
+273
+00:26:01,440 --> 00:26:05,860
+The shop is on the left. My friend is on the way
+
+274
+00:26:05,860 --> 00:26:10,880
+to Moscow. Okay? Write this information on the
+
+275
+00:26:10,880 --> 00:26:15,160
+front of the letter. When she was a little girl,
+
+276
+00:26:15,480 --> 00:26:19,940
+people saw a realistic cowboy film on television.
+
+277
+00:26:21,620 --> 00:26:27,380
+On. Still, we have other propositions referring to
+
+278
+00:26:27,380 --> 00:26:33,600
+a place. Okay. So you have above, across, after,
+
+279
+00:26:33,940 --> 00:26:38,820
+against, along, among, around, behind, below,
+
+280
+00:26:39,180 --> 00:26:48,500
+beside, between. Okay. We spoke about in, on, and
+
+281
+00:26:48,500 --> 00:26:52,960
+now we have, we spoke about at yes, now we have
+
+282
+00:26:52,960 --> 00:26:53,520
+above.
+
+283
+00:27:05,960 --> 00:27:10,780
+So above refers to higher than something. The
+
+284
+00:27:10,780 --> 00:27:14,420
+picture hangs above my bed.
+
+285
+00:27:17,700 --> 00:27:25,540
+Above. The fan is above us. The ceiling is above
+
+286
+00:27:25,540 --> 00:27:32,400
+us. Above. You have a space between two objects.
+
+287
+00:27:32,960 --> 00:27:33,940
+Okay?
+
+288
+00:27:36,090 --> 00:27:41,890
+across from one side to the other side. You must
+
+289
+00:27:41,890 --> 00:27:46,610
+not go across this road here. There isn't a bridge
+
+290
+00:27:46,610 --> 00:27:48,990
+across the river. Across.
+
+291
+00:27:51,970 --> 00:27:55,370
+Okay, once you cross one point to another point,
+
+292
+00:27:55,510 --> 00:27:59,170
+you use once you pass one point to another point,
+
+293
+00:27:59,290 --> 00:28:02,710
+you use across. After.
+
+294
+00:28:05,560 --> 00:28:09,800
+One follows the other. The cat ran after the dog.
+
+295
+00:28:10,440 --> 00:28:18,320
+Chased the dog. Okay? After you. Against. This
+
+296
+00:28:18,320 --> 00:28:21,480
+means directed towards something. The bird flew
+
+297
+00:28:21,480 --> 00:28:22,740
+against the window.
+
+298
+00:28:26,840 --> 00:28:31,640
+Directed towards something. The bird flew against
+
+299
+00:28:31,640 --> 00:28:37,650
+the window. Along. In line with. From one point to
+
+300
+00:28:37,650 --> 00:28:42,110
+another. They are walking along the beach. They
+
+301
+00:28:42,110 --> 00:28:45,390
+are walking along the beach. Along the river.
+
+302
+00:28:46,630 --> 00:28:50,630
+Along the
+
+303
+00:28:50,630 --> 00:28:53,370
+university. Along the university walls.
+
+304
+00:28:56,230 --> 00:29:04,030
+Among. I like being among people. So between,
+
+305
+00:29:04,110 --> 00:29:07,930
+between, it refers to two people. However, among
+
+306
+00:29:07,930 --> 00:29:09,770
+refers to plural.
+
+307
+00:29:11,930 --> 00:29:17,010
+Around, this is circular way. Circular way refers
+
+308
+00:29:17,010 --> 00:29:23,830
+to circle. We are sitting around the campfire. The
+
+309
+00:29:23,830 --> 00:29:26,410
+students circled around the teacher.
+
+310
+00:29:30,080 --> 00:29:34,180
+Behind, at the back of. Our house is behind the
+
+311
+00:29:34,180 --> 00:29:39,960
+supermarket. Behind the supermarket. Below, lower
+
+312
+00:29:39,960 --> 00:29:45,980
+than something. This valley is 86 meters below the
+
+313
+00:29:45,980 --> 00:29:46,520
+sea level.
+
+314
+00:29:51,480 --> 00:29:56,620
+Jericho is below the sea level.
+
+315
+00:29:59,630 --> 00:30:04,050
+Beside means next to our house is beside the
+
+316
+00:30:04,050 --> 00:30:12,750
+supermarket Between and between two things By
+
+317
+00:30:12,750 --> 00:30:17,590
+means near he lives in the house by the river and
+
+318
+00:30:17,590 --> 00:30:22,930
+he close to the river Okay close to also means
+
+319
+00:30:22,930 --> 00:30:26,770
+near our house is close to the supermarket and
+
+320
+00:30:27,310 --> 00:30:33,670
+Down, he came down the hill. Up, he came up the
+
+321
+00:30:33,670 --> 00:30:39,750
+stairs. From this place where it starts, the train
+
+322
+00:30:39,750 --> 00:30:44,730
+or the bus came from Rafah to Gaza.
+
+323
+00:30:47,530 --> 00:30:53,450
+Do you come from Tokyo? Where are you from? I'm
+
+324
+00:30:53,450 --> 00:30:54,170
+from Palestine.
+
+325
+00:31:03,470 --> 00:31:07,130
+In front of. Our house is in front of the
+
+326
+00:31:07,130 --> 00:31:11,530
+supermarket. Inside. You shouldn't stay inside the
+
+327
+00:31:11,530 --> 00:31:16,350
+castle. Into. She came into the room. This means
+
+328
+00:31:16,350 --> 00:31:21,670
+to the sudden coming of someone. She came into the
+
+329
+00:31:21,670 --> 00:31:28,420
+room. You shouldn't go into the castle. Okay? Near
+
+330
+00:31:28,420 --> 00:31:31,300
+this is close to also our house is near the
+
+331
+00:31:31,300 --> 00:31:34,880
+supermarket next to our house is next to the
+
+332
+00:31:34,880 --> 00:31:40,860
+supermarket We live in the next door Okay off and
+
+333
+00:31:40,860 --> 00:31:45,360
+away from something the cat jumped off the roof
+
+334
+00:31:45,360 --> 00:31:51,200
+Onto moving to a place the cat jumped onto the
+
+335
+00:31:51,200 --> 00:31:57,360
+roof opposite On the other side, our house is
+
+336
+00:31:57,360 --> 00:32:02,920
+opposite the supermarket. The cat jumped out of
+
+337
+00:32:02,920 --> 00:32:04,960
+the window. This is leaving something.
+
+338
+00:32:07,820 --> 00:32:15,740
+We have outside. Can you wait outside? It is the
+
+339
+00:32:15,740 --> 00:32:21,750
+opposite of inside. Over. this is above something
+
+340
+00:32:21,750 --> 00:32:27,890
+the cat jumped over the wall over the wall okay
+
+341
+00:32:27,890 --> 00:32:31,410
+jumped over the wall so there is no space once you
+
+342
+00:32:31,410 --> 00:32:35,490
+have a space it is above once there'll be no space
+
+343
+00:32:35,490 --> 00:32:41,050
+or very specific space then becomes also over past
+
+344
+00:32:41,050 --> 00:32:46,010
+go past the post office go near the post office
+
+345
+00:32:46,950 --> 00:32:50,970
+Round, of course, circle. We are sitting around
+
+346
+00:32:50,970 --> 00:32:56,490
+the campfire. Through, you shouldn't walk through
+
+347
+00:32:56,490 --> 00:33:02,650
+the forest. عبر يعني. To refers to the verbs of
+
+348
+00:33:02,650 --> 00:33:06,730
+motion. Where do you have motion, حركة, you use
+
+349
+00:33:06,730 --> 00:33:10,650
+to. I like going to Australia. Can you come to me?
+
+350
+00:33:11,480 --> 00:33:16,560
+I've never been to Africa. Travel is motion. I go
+
+351
+00:33:16,560 --> 00:33:21,540
+to school every day. He came to London for the
+
+352
+00:33:21,540 --> 00:33:26,360
+first time. Two. Towards. We ran towards the
+
+353
+00:33:26,360 --> 00:33:31,740
+castle. This is the direction of something. Under
+
+354
+00:33:31,740 --> 00:33:38,040
+is the opposite of up. The cat is under the table.
+
+355
+00:33:38,620 --> 00:33:41,420
+He went up the hill. Okay?
+
+356
+00:33:46,420 --> 00:33:55,640
+Now semantically, prepositions of English have
+
+357
+00:33:55,640 --> 00:34:00,800
+a meaning and this syntactically refers to some
+
+358
+00:34:00,800 --> 00:34:06,520
+syntactic function. So the preposition is a word
+
+359
+00:34:06,520 --> 00:34:11,340
+that is used to connect noun and noun. structure
+
+360
+00:34:11,340 --> 00:34:14,520
+to another structure in the sentence, I mean
+
+361
+00:34:14,520 --> 00:34:20,940
+syntactically. The girl is in the garden. The
+
+362
+00:34:20,940 --> 00:34:27,950
+prepositional object can be Pronoun can be a
+
+363
+00:34:27,950 --> 00:34:31,990
+pronoun, can be adjective, can be adverb, can be a
+
+364
+00:34:31,990 --> 00:34:35,650
+clause, can be a gerund. The girl is in the
+
+365
+00:34:35,650 --> 00:34:40,170
+garden. Ahmed is behind me. This is pronoun. He is
+
+366
+00:34:40,170 --> 00:34:48,250
+clever at tennis. Clever at. Adjective. Okay. An
+
+367
+00:34:48,250 --> 00:34:52,910
+adverb. He ran too quickly for his years. I don't
+
+368
+00:34:52,910 --> 00:34:57,470
+know. I don't care for what you are saying. What
+
+369
+00:34:57,470 --> 00:35:01,870
+you are saying. I don't care for what you are
+
+370
+00:35:01,870 --> 00:35:04,930
+saying. What you are saying is a close. We thought
+
+371
+00:35:04,930 --> 00:35:08,310
+about giving a present. Giving a present is a
+
+372
+00:35:08,310 --> 00:35:08,670
+gerund.
+
+373
+00:35:14,750 --> 00:35:19,760
+Now we have The preposition can be used for making
+
+374
+00:35:19,760 --> 00:35:25,800
+phrasal verbs. Take after, get at, run out of, for
+
+375
+00:35:25,800 --> 00:35:32,620
+example. Come into, come in, come out. These are
+
+376
+00:35:32,620 --> 00:35:37,380
+phrasal verbs. They are also used for making
+
+377
+00:35:37,380 --> 00:35:43,100
+idiomatic adjectives like grateful to, angry with.
+
+378
+00:35:48,100 --> 00:35:50,600
+We have also prepositional phrases like the
+
+379
+00:35:50,600 --> 00:35:54,100
+soldier fought with great bravery with great
+
+380
+00:35:54,100 --> 00:35:58,080
+bravery Prepositional phrases the man or the men
+
+381
+00:35:58,080 --> 00:36:03,080
+The man in the brown coat is my friend in the
+
+382
+00:36:03,080 --> 00:36:10,260
+brown coat prepositional phrase Okay however in
+
+383
+00:36:10,260 --> 00:36:14,340
+Arabic The preposition is a kind of conjunction
+
+384
+00:36:14,340 --> 00:36:18,220
+that can connect two parts of the sentence with
+
+385
+00:36:18,220 --> 00:36:24,740
+each other. So they convey a syntactic relation
+
+386
+00:36:24,740 --> 00:36:31,260
+between noun and verb. This is in Arabic. So we
+
+387
+00:36:31,260 --> 00:36:36,360
+have وقع الكتاب من أحمد. وقع الكتاب من أحمد. This
+
+388
+00:36:36,360 --> 00:36:40,720
+is transitive or intransitive verb. intransitive
+
+389
+00:36:40,720 --> 00:36:47,180
+أخذت الكتابة من علي جلست على البسات وصلت في ساعة
+
+390
+00:36:47,180 --> 00:36:52,240
+كتبت بالقلم all of these sentences are
+
+391
+00:36:52,240 --> 00:36:58,420
+intransitive they contain intransitive there also
+
+392
+00:36:58,420 --> 00:37:03,520
+we have derivational derivations
+
+393
+00:37:03,520 --> 00:37:07,550
+and their phrases In case of having derivation and
+
+394
+00:37:07,550 --> 00:37:12,610
+their phrases, we have the preposition. In, ana
+
+395
+00:37:12,610 --> 00:37:18,610
+katibun bilqalam. Katib, this is derived. This is
+
+396
+00:37:18,610 --> 00:37:22,410
+nominal subject. Ism fa'al. Ana katibun bilqalam.
+
+397
+00:37:22,910 --> 00:37:26,550
+Alqalamu maktubun bihi. Katib maktub. What do you
+
+398
+00:37:26,550 --> 00:37:30,670
+call this? These are called derivations. You still
+
+399
+00:37:30,670 --> 00:37:31,810
+recall morphology.
+
+400
+00:37:53,150 --> 00:37:58,770
+These are derivations. We use the preposition ب
+
+401
+00:37:58,770 --> 00:38:01,670
+which is equivalent to في.
+
+402
+00:38:04,820 --> 00:38:10,680
+we have also abstract meaning or abstract semantic
+
+403
+00:38:10,680 --> 00:38:18,320
+function for the prepositions okay لَيْسَ زَيْدٌ
+
+404
+00:38:18,320 --> 00:38:23,600
+قَائِمٌ حقًا so the meaning is purely abstract
+
+405
+00:38:29,410 --> 00:38:32,930
+Mostly the preposition as we the preposition in
+
+406
+00:38:32,930 --> 00:38:38,150
+English Depends on the noun following it. I say on
+
+407
+00:38:38,150 --> 00:38:48,550
+Sunday in July in winter on the island in London
+
+408
+00:38:49,520 --> 00:38:54,360
+at school so it depends on the prepositional noun
+
+409
+00:38:54,360 --> 00:39:01,100
+or the I mean the post noun say that the we have
+
+410
+00:39:01,100 --> 00:39:05,540
+preposition phrase so the modifier of the of of
+
+411
+00:39:05,540 --> 00:39:09,100
+the preposition decides the use of this
+
+412
+00:39:09,100 --> 00:39:12,580
+preposition which preposition we could use it
+
+413
+00:39:12,580 --> 00:39:16,740
+depends on the modifier following it okay on the
+
+414
+00:39:16,740 --> 00:39:21,000
+noun following it You see? So this is the
+
+415
+00:39:21,000 --> 00:39:21,500
+proposition.
+
+416
+00:39:24,260 --> 00:39:27,500
+The story of the proposition, as I mentioned, is
+
+417
+00:39:27,500 --> 00:39:32,690
+very tricky. it needs more focus more explanation
+
+418
+00:39:32,690 --> 00:39:38,270
+more use it depends on more practice so the more
+
+419
+00:39:38,270 --> 00:39:41,210
+you practice prepositions the more you use them
+
+420
+00:39:41,210 --> 00:39:44,630
+this means that we have to use them contextually
+
+421
+00:39:44,630 --> 00:39:48,490
+and in situational use next time we are going to
+
+422
+00:39:48,490 --> 00:39:51,970
+practice using prepositions and we are going to
+
+423
+00:39:51,970 --> 00:39:55,330
+see your preparations your presentations so please
+
+424
+00:39:56,010 --> 00:39:59,710
+have your presentations ready for next time for
+
+425
+00:39:59,710 --> 00:40:03,010
+teaching prepositions and interpreting
+
+426
+00:40:03,010 --> 00:40:06,690
+prepositions at the same time okay that's it for
+
+427
+00:40:06,690 --> 00:40:07,490
+today thank you
+
diff --git a/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/TDnUSeo1_6c_raw.json b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/TDnUSeo1_6c_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..dbec33b5bb317c25ba64e36dc1d722240f54f77a
--- /dev/null
+++ b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/TDnUSeo1_6c_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 1430, "start": 12.9, "end": 14.3, "text": " Bismillahirrahmanirrahim", "tokens": [34594, 32703, 347, 15688, 1601, 347, 15688, 332], "avg_logprob": -0.2782118055555556, "compression_ratio": 0.8620689655172413, "no_speech_prob": 0.0, "words": [{"start": 12.9, "end": 14.3, "word": " Bismillahirrahmanirrahim", "probability": 0.792510986328125}], "temperature": 1.0}, {"id": 2, "seek": 4273, "start": 15.37, "end": 42.73, "text": " Today we are going to continue with futurity once again. We need to see futurity in English and futurity in Arabic. We have already spoken about future simple, future continuous, future perfect, future perfect continuous. And we've seen that these constructions are available in both English and Arabic. However, the constructions are different in both languages.", "tokens": [2692, 321, 366, 516, 281, 2354, 365, 1877, 3051, 1564, 797, 13, 492, 643, 281, 536, 1877, 3051, 294, 3669, 293, 1877, 3051, 294, 19938, 13, 492, 362, 1217, 10759, 466, 2027, 2199, 11, 2027, 10957, 11, 2027, 2176, 11, 2027, 2176, 10957, 13, 400, 321, 600, 1612, 300, 613, 7690, 626, 366, 2435, 294, 1293, 3669, 293, 19938, 13, 2908, 11, 264, 7690, 626, 366, 819, 294, 1293, 8650, 13], "avg_logprob": -0.1195746526742975, "compression_ratio": 1.793103448275862, "no_speech_prob": 0.0, "words": [{"start": 15.37, "end": 15.71, "word": " Today", "probability": 0.8642578125}, {"start": 15.71, "end": 15.85, "word": " we", "probability": 0.60107421875}, {"start": 15.85, "end": 15.95, "word": " are", "probability": 0.755859375}, {"start": 15.95, "end": 16.11, "word": " going", "probability": 0.935546875}, {"start": 16.11, "end": 16.21, "word": " to", "probability": 0.96875}, {"start": 16.21, "end": 16.63, "word": " continue", "probability": 0.89501953125}, {"start": 16.63, "end": 17.01, "word": " with", "probability": 0.91650390625}, {"start": 17.01, "end": 17.57, "word": " futurity", "probability": 0.60479736328125}, {"start": 17.57, "end": 18.25, "word": " once", "probability": 0.83056640625}, {"start": 18.25, "end": 18.53, "word": " again.", "probability": 0.955078125}, {"start": 18.61, "end": 18.67, "word": " We", "probability": 0.94580078125}, {"start": 18.67, "end": 18.83, "word": " need", "probability": 0.912109375}, {"start": 18.83, "end": 18.93, "word": " to", "probability": 0.97265625}, {"start": 18.93, "end": 19.13, "word": " see", "probability": 0.919921875}, {"start": 19.13, "end": 19.63, "word": " futurity", "probability": 0.935302734375}, {"start": 19.63, "end": 19.91, "word": " in", "probability": 0.94921875}, {"start": 19.91, "end": 20.27, "word": " English", "probability": 0.978515625}, {"start": 20.27, "end": 21.05, "word": " and", "probability": 0.8291015625}, {"start": 21.05, "end": 21.65, "word": " futurity", "probability": 0.96630859375}, {"start": 21.65, "end": 21.97, "word": " in", "probability": 0.95166015625}, {"start": 21.97, "end": 22.29, "word": " Arabic.", "probability": 0.92138671875}, {"start": 22.85, "end": 23.09, "word": " We", "probability": 0.9609375}, {"start": 23.09, "end": 23.27, "word": " have", "probability": 0.9423828125}, {"start": 23.27, "end": 23.63, "word": " already", "probability": 0.931640625}, {"start": 23.63, "end": 24.13, "word": " spoken", "probability": 0.9384765625}, {"start": 24.13, "end": 24.79, "word": " about", "probability": 0.89404296875}, {"start": 24.79, "end": 25.79, "word": " future", "probability": 0.94189453125}, {"start": 25.79, "end": 26.25, "word": " simple,", "probability": 0.88427734375}, {"start": 26.95, "end": 27.25, "word": " future", "probability": 0.9833984375}, {"start": 27.25, "end": 27.81, "word": " continuous,", "probability": 0.84619140625}, {"start": 28.65, "end": 29.05, "word": " future", "probability": 0.98388671875}, {"start": 29.05, "end": 29.59, "word": " perfect,", "probability": 0.9248046875}, {"start": 30.27, "end": 30.59, "word": " future", "probability": 0.98291015625}, {"start": 30.59, "end": 31.11, "word": " perfect", "probability": 0.92138671875}, {"start": 31.11, "end": 31.63, "word": " continuous.", "probability": 0.78466796875}, {"start": 32.43, "end": 32.65, "word": " And", "probability": 0.92724609375}, {"start": 32.65, "end": 32.93, "word": " we've", "probability": 0.89404296875}, {"start": 32.93, "end": 33.25, "word": " seen", "probability": 0.9541015625}, {"start": 33.25, "end": 33.51, "word": " that", "probability": 0.908203125}, {"start": 33.51, "end": 34.03, "word": " these", "probability": 0.84423828125}, {"start": 34.03, "end": 34.95, "word": " constructions", "probability": 0.94384765625}, {"start": 34.95, "end": 35.67, "word": " are", "probability": 0.9365234375}, {"start": 35.67, "end": 36.15, "word": " available", "probability": 0.845703125}, {"start": 36.15, "end": 36.55, "word": " in", "probability": 0.947265625}, {"start": 36.55, "end": 36.79, "word": " both", "probability": 0.88671875}, {"start": 36.79, "end": 37.29, "word": " English", "probability": 0.9775390625}, {"start": 37.29, "end": 38.05, "word": " and", "probability": 0.93896484375}, {"start": 38.05, "end": 38.49, "word": " Arabic.", "probability": 0.90185546875}, {"start": 39.11, "end": 39.51, "word": " However,", "probability": 0.88330078125}, {"start": 39.59, "end": 39.77, "word": " the", "probability": 0.91796875}, {"start": 39.77, "end": 40.61, "word": " constructions", "probability": 0.945068359375}, {"start": 40.61, "end": 41.31, "word": " are", "probability": 0.939453125}, {"start": 41.31, "end": 41.77, "word": " different", "probability": 0.89208984375}, {"start": 41.77, "end": 41.99, "word": " in", "probability": 0.93017578125}, {"start": 41.99, "end": 42.23, "word": " both", "probability": 0.88818359375}, {"start": 42.23, "end": 42.73, "word": " languages.", "probability": 0.9697265625}], "temperature": 1.0}, {"id": 3, "seek": 6531, "start": 43.47, "end": 65.31, "text": " The syntactic construction of future simple is different from the syntactic construction of future simple in English. Its usage is of more functions, more semantic functions in English rather than it in Arabic. However, we have", "tokens": [440, 23980, 19892, 6435, 295, 2027, 2199, 307, 819, 490, 264, 23980, 19892, 6435, 295, 2027, 2199, 294, 3669, 13, 6953, 14924, 307, 295, 544, 6828, 11, 544, 47982, 6828, 294, 3669, 2831, 813, 309, 294, 19938, 13, 2908, 11, 321, 362], "avg_logprob": -0.16987646041914475, "compression_ratio": 1.6521739130434783, "no_speech_prob": 0.0, "words": [{"start": 43.47, "end": 43.75, "word": " The", "probability": 0.398193359375}, {"start": 43.75, "end": 44.89, "word": " syntactic", "probability": 0.90673828125}, {"start": 44.89, "end": 45.47, "word": " construction", "probability": 0.93505859375}, {"start": 45.47, "end": 46.03, "word": " of", "probability": 0.96728515625}, {"start": 46.03, "end": 47.25, "word": " future", "probability": 0.74560546875}, {"start": 47.25, "end": 47.69, "word": " simple", "probability": 0.70166015625}, {"start": 47.69, "end": 48.21, "word": " is", "probability": 0.89892578125}, {"start": 48.21, "end": 48.61, "word": " different", "probability": 0.8876953125}, {"start": 48.61, "end": 48.85, "word": " from", "probability": 0.86376953125}, {"start": 48.85, "end": 49.03, "word": " the", "probability": 0.890625}, {"start": 49.03, "end": 49.47, "word": " syntactic", "probability": 0.936767578125}, {"start": 49.47, "end": 50.05, "word": " construction", "probability": 0.9248046875}, {"start": 50.05, "end": 50.33, "word": " of", "probability": 0.95703125}, {"start": 50.33, "end": 50.61, "word": " future", "probability": 0.9619140625}, {"start": 50.61, "end": 51.09, "word": " simple", "probability": 0.93994140625}, {"start": 51.09, "end": 51.79, "word": " in", "probability": 0.93896484375}, {"start": 51.79, "end": 52.19, "word": " English.", "probability": 0.9609375}, {"start": 53.33, "end": 54.21, "word": " Its", "probability": 0.448486328125}, {"start": 54.21, "end": 54.81, "word": " usage", "probability": 0.9404296875}, {"start": 54.81, "end": 55.79, "word": " is", "probability": 0.90966796875}, {"start": 55.79, "end": 56.51, "word": " of", "probability": 0.8837890625}, {"start": 56.51, "end": 56.83, "word": " more", "probability": 0.94384765625}, {"start": 56.83, "end": 57.53, "word": " functions,", "probability": 0.78173828125}, {"start": 57.97, "end": 58.15, "word": " more", "probability": 0.93359375}, {"start": 58.15, "end": 58.55, "word": " semantic", "probability": 0.95458984375}, {"start": 58.55, "end": 59.31, "word": " functions", "probability": 0.9033203125}, {"start": 59.31, "end": 60.01, "word": " in", "probability": 0.80078125}, {"start": 60.01, "end": 60.33, "word": " English", "probability": 0.97802734375}, {"start": 60.33, "end": 60.67, "word": " rather", "probability": 0.86083984375}, {"start": 60.67, "end": 61.01, "word": " than", "probability": 0.95166015625}, {"start": 61.01, "end": 61.31, "word": " it", "probability": 0.50439453125}, {"start": 61.31, "end": 61.85, "word": " in", "probability": 0.880859375}, {"start": 61.85, "end": 62.15, "word": " Arabic.", "probability": 0.93017578125}, {"start": 62.73, "end": 63.09, "word": " However,", "probability": 0.87353515625}, {"start": 63.53, "end": 64.95, "word": " we", "probability": 0.95166015625}, {"start": 64.95, "end": 65.31, "word": " have", "probability": 0.9443359375}], "temperature": 1.0}, {"id": 4, "seek": 7888, "start": 67.66, "end": 78.88, "text": " Other constructions like future continuous, future perfect, future perfect continuous, they are represented in Arabic lexically.", "tokens": [5358, 7690, 626, 411, 2027, 10957, 11, 2027, 2176, 11, 2027, 2176, 10957, 11, 436, 366, 10379, 294, 19938, 476, 87, 984, 13], "avg_logprob": -0.1720377542078495, "compression_ratio": 1.372340425531915, "no_speech_prob": 0.0, "words": [{"start": 67.66000000000001, "end": 68.60000000000001, "word": " Other", "probability": 0.7783203125}, {"start": 68.60000000000001, "end": 69.54, "word": " constructions", "probability": 0.882080078125}, {"start": 69.54, "end": 70.58, "word": " like", "probability": 0.56103515625}, {"start": 70.58, "end": 71.0, "word": " future", "probability": 0.88916015625}, {"start": 71.0, "end": 71.74, "word": " continuous,", "probability": 0.80908203125}, {"start": 72.34, "end": 72.68, "word": " future", "probability": 0.97412109375}, {"start": 72.68, "end": 73.22, "word": " perfect,", "probability": 0.90966796875}, {"start": 73.72, "end": 74.04, "word": " future", "probability": 0.96435546875}, {"start": 74.04, "end": 74.52, "word": " perfect", "probability": 0.92529296875}, {"start": 74.52, "end": 75.26, "word": " continuous,", "probability": 0.8330078125}, {"start": 75.68, "end": 75.8, "word": " they", "probability": 0.82958984375}, {"start": 75.8, "end": 75.96, "word": " are", "probability": 0.93896484375}, {"start": 75.96, "end": 76.42, "word": " represented", "probability": 0.78125}, {"start": 76.42, "end": 76.64, "word": " in", "probability": 0.95361328125}, {"start": 76.64, "end": 77.12, "word": " Arabic", "probability": 0.90625}, {"start": 77.12, "end": 78.88, "word": " lexically.", "probability": 0.9088541666666666}], "temperature": 1.0}, {"id": 5, "seek": 10374, "start": 79.6, "end": 103.74, "text": " Okay? And grammatically. However, in English, we have specific rules for each construction. These are not verbs. They consist of different parts of inflections or inflection phrase. Future simple consists of, once I go, I will travel to London.", "tokens": [1033, 30, 400, 17570, 5030, 13, 2908, 11, 294, 3669, 11, 321, 362, 2685, 4474, 337, 1184, 6435, 13, 1981, 366, 406, 30051, 13, 814, 4603, 295, 819, 3166, 295, 1536, 1809, 626, 420, 1536, 5450, 9535, 13, 20805, 2199, 14689, 295, 11, 1564, 286, 352, 11, 286, 486, 3147, 281, 7042, 13], "avg_logprob": -0.1572627298257969, "compression_ratio": 1.3920454545454546, "no_speech_prob": 0.0, "words": [{"start": 79.6, "end": 79.96, "word": " Okay?", "probability": 0.478759765625}, {"start": 80.5, "end": 80.86, "word": " And", "probability": 0.8564453125}, {"start": 80.86, "end": 82.76, "word": " grammatically.", "probability": 0.82763671875}, {"start": 82.92, "end": 83.2, "word": " However,", "probability": 0.87548828125}, {"start": 83.48, "end": 83.66, "word": " in", "probability": 0.9541015625}, {"start": 83.66, "end": 84.1, "word": " English,", "probability": 0.97705078125}, {"start": 84.64, "end": 84.74, "word": " we", 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129.04, "end": 146.56, "text": " aspect which simple aspect okay so for future simple what are the semantic functions of this construction the semantic functions of this concept we have willingness yes offer", "tokens": [4171, 597, 2199, 4171, 1392, 370, 337, 2027, 2199, 437, 366, 264, 47982, 6828, 295, 341, 6435, 264, 47982, 6828, 295, 341, 3410, 321, 362, 25069, 2086, 2626], "avg_logprob": -0.2171336268556529, "compression_ratio": 1.6666666666666667, "no_speech_prob": 0.0, "words": [{"start": 129.04, "end": 129.64, "word": " aspect", "probability": 0.372802734375}, {"start": 129.64, "end": 130.1, "word": " which", "probability": 0.376953125}, {"start": 130.1, "end": 131.06, "word": " simple", "probability": 0.5556640625}, {"start": 131.06, "end": 131.74, "word": " aspect", "probability": 0.86181640625}, {"start": 131.74, "end": 132.5, "word": " okay", "probability": 0.74169921875}, {"start": 132.5, "end": 133.56, "word": " so", "probability": 0.74560546875}, {"start": 133.56, "end": 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Okay? Here we have different usages of the modal auxiliaries shell or will. In case of willingness, we use shell with what? 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We use shell with the second and third person. So we have different semantic functions for the future simple. However, in English, in Arabic, we have some sort of limitations semantically. We have willingness in Arabic, we have requests, we have all these meanings, okay? But we find that", "tokens": [293, 4734, 13, 492, 764, 8720, 365, 264, 1150, 293, 2636, 954, 13, 407, 321, 362, 819, 47982, 6828, 337, 264, 2027, 2199, 13, 2908, 11, 294, 3669, 11, 294, 19938, 11, 321, 362, 512, 1333, 295, 15705, 4361, 49505, 13, 492, 362, 25069, 294, 19938, 11, 321, 362, 12475, 11, 321, 362, 439, 613, 28138, 11, 1392, 30, 583, 321, 915, 300], "avg_logprob": -0.2053222598042339, "compression_ratio": 1.5759162303664922, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 198.99, "end": 199.39, "word": " and", "probability": 0.455322265625}, {"start": 199.39, "end": 199.69, "word": " threat.", "probability": 0.72802734375}, {"start": 199.85, "end": 199.93, "word": " We", "probability": 0.91845703125}, {"start": 199.93, "end": 200.17, "word": " use", "probability": 0.87548828125}, {"start": 200.17, "end": 200.49, "word": " shell", "probability": 0.81494140625}, {"start": 200.49, "end": 200.69, "word": " with", "probability": 0.865234375}, {"start": 200.69, "end": 200.81, "word": " the", "probability": 0.8349609375}, {"start": 200.81, "end": 201.09, "word": " second", "probability": 0.89501953125}, {"start": 201.09, "end": 201.47, "word": " and", "probability": 0.93115234375}, {"start": 201.47, "end": 201.89, "word": " third", "probability": 0.9375}, {"start": 201.89, "end": 202.85, "word": " person.", "probability": 0.87841796875}, {"start": 203.27, "end": 203.49, "word": " So", "probability": 0.90576171875}, {"start": 203.49, "end": 203.61, "word": " we", "probability": 0.80126953125}, {"start": 203.61, "end": 203.77, "word": " have", "probability": 0.94677734375}, {"start": 203.77, "end": 204.15, "word": " different", "probability": 0.896484375}, {"start": 204.15, "end": 204.61, "word": " semantic", "probability": 0.947265625}, {"start": 204.61, "end": 205.29, "word": " functions", "probability": 0.90380859375}, {"start": 205.29, "end": 206.23, "word": " for", "probability": 0.93701171875}, {"start": 206.23, "end": 206.83, "word": " the", "probability": 0.8623046875}, {"start": 206.83, "end": 207.13, "word": " future", "probability": 0.97021484375}, {"start": 207.13, "end": 207.59, "word": " simple.", "probability": 0.66552734375}, {"start": 208.53, "end": 208.83, "word": " However,", "probability": 0.845703125}, {"start": 209.15, "end": 209.29, "word": " in", "probability": 0.9560546875}, {"start": 209.29, "end": 209.89, "word": " English,", "probability": 0.5966796875}, {"start": 210.01, "end": 210.11, "word": " in", "probability": 0.94775390625}, {"start": 210.11, "end": 210.39, "word": " Arabic,", "probability": 0.90576171875}, {"start": 210.85, "end": 211.45, "word": " we", "probability": 0.95947265625}, {"start": 211.45, "end": 211.85, "word": " have", "probability": 0.947265625}, {"start": 211.85, "end": 212.13, "word": " some", "probability": 0.8857421875}, {"start": 212.13, "end": 212.55, "word": " sort", "probability": 0.90673828125}, {"start": 212.55, "end": 213.05, "word": " of", "probability": 0.970703125}, {"start": 213.05, "end": 214.79, "word": " limitations", "probability": 0.81591796875}, {"start": 214.79, "end": 216.27, "word": " semantically.", "probability": 0.85205078125}, {"start": 216.81, "end": 217.17, "word": " We", "probability": 0.9580078125}, {"start": 217.17, "end": 217.39, "word": " have", "probability": 0.94482421875}, {"start": 217.39, "end": 217.71, "word": " willingness", "probability": 0.8603515625}, {"start": 217.71, "end": 218.01, "word": " in", "probability": 0.86962890625}, {"start": 218.01, "end": 218.31, "word": " Arabic,", "probability": 0.8974609375}, {"start": 218.93, "end": 219.21, "word": " we", "probability": 0.9580078125}, {"start": 219.21, "end": 219.43, "word": " have", "probability": 0.9443359375}, {"start": 219.43, "end": 219.93, "word": " requests,", "probability": 0.53173828125}, {"start": 220.11, "end": 220.25, "word": " we", "probability": 0.95166015625}, {"start": 220.25, "end": 220.45, "word": " have", "probability": 0.94482421875}, {"start": 220.45, "end": 220.97, "word": " all", "probability": 0.94873046875}, {"start": 220.97, "end": 221.35, "word": " these", "probability": 0.84814453125}, {"start": 221.35, "end": 221.87, "word": " meanings,", "probability": 0.94140625}, {"start": 222.45, "end": 222.71, "word": " okay?", "probability": 0.80859375}, {"start": 223.09, "end": 223.39, "word": " But", "probability": 0.9375}, {"start": 223.39, "end": 223.55, "word": " we", "probability": 0.92626953125}, {"start": 223.55, "end": 223.93, "word": " find", "probability": 0.89501953125}, {"start": 223.93, "end": 224.33, "word": " that", "probability": 0.9375}], "temperature": 1.0}, {"id": 11, "seek": 25420, "start": 225.2, "end": 254.2, "text": " Future simple is available once expressing willingness. We use سوف يرجع البضاعة. سوف يرجع. سوف, this is the future particle in Arabic, which refers to remote future or near future? Remote future. Okay. سوف يرجع. 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So, how could you translate this into English?", "tokens": [3300, 2874, 1434, 8038, 366, 1009, 7784, 294, 264, 661, 7690, 626, 11, 2027, 10957, 11, 2027, 2176, 11, 2027, 2176, 10957, 11, 1030, 11458, 13, 407, 11, 577, 727, 291, 13799, 341, 666, 3669, 30], "avg_logprob": -0.23247466699497119, "compression_ratio": 1.4724409448818898, "no_speech_prob": 0.0, "words": [{"start": 299.02, "end": 299.78, "word": " Errorism", "probability": 0.8037109375}, {"start": 299.78, "end": 300.48, "word": " mistakes", "probability": 0.76416015625}, {"start": 300.48, "end": 301.88, "word": " are", "probability": 0.75244140625}, {"start": 301.88, "end": 302.18, "word": " always", "probability": 0.9189453125}, {"start": 302.18, "end": 302.68, "word": " committed", "probability": 0.95849609375}, {"start": 302.68, "end": 303.1, "word": " in", "probability": 0.92919921875}, {"start": 303.1, "end": 303.22, "word": " the", "probability": 0.86083984375}, {"start": 303.22, "end": 303.5, "word": " other", 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You are expected to graduate in June, so I am going to attend your graduation ceremony, okay? Or celebration. Here I have intention, I have intention to attend, okay? 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Going to. She has a cause. Okay. She has a cause. She's pregnant and she will deliver according to the plan next month. Okay. So we say she's going to. She's going to have a baby next month. Okay. I'm going to attend your graduation party next June. 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I'm going to attend Ahmed's party tonight. We have intention to do that. Okay. So going to refers to intention and cause. It will rain soon or it's going to rain. What was it? It's going to rain because we have cloudy weather. So we have cause.", "tokens": [1033, 13, 286, 478, 516, 281, 6888, 39189, 311, 3595, 4440, 13, 492, 362, 7789, 281, 360, 300, 13, 1033, 13, 407, 516, 281, 14942, 281, 7789, 293, 3082, 13, 467, 486, 4830, 2321, 420, 309, 311, 516, 281, 4830, 13, 708, 390, 309, 30, 467, 311, 516, 281, 4830, 570, 321, 362, 33060, 5503, 13, 407, 321, 362, 3082, 13], "avg_logprob": -0.1549899215179105, "compression_ratio": 1.62987012987013, "no_speech_prob": 0.0, "words": [{"start": 501.19, "end": 501.55, "word": " Okay.", "probability": 0.470947265625}, {"start": 501.87, "end": 502.23, "word": " I'm", "probability": 0.787109375}, {"start": 502.23, "end": 502.63, "word": " going", "probability": 0.94873046875}, {"start": 502.63, "end": 502.85, "word": " to", "probability": 0.9755859375}, {"start": 502.85, "end": 503.33, "word": " attend", "probability": 0.888671875}, {"start": 503.33, "end": 503.95, "word": " Ahmed's", "probability": 0.828369140625}, {"start": 503.95, "end": 504.25, "word": " party", "probability": 0.88818359375}, {"start": 504.25, "end": 504.83, "word": " tonight.", "probability": 0.8515625}, {"start": 505.91, "end": 506.57, "word": " We", "probability": 0.9453125}, {"start": 506.57, "end": 506.75, "word": " have", "probability": 0.94921875}, {"start": 506.75, "end": 507.19, "word": " intention", "probability": 0.91552734375}, {"start": 507.19, "end": 507.41, "word": " to", "probability": 0.97021484375}, {"start": 507.41, "end": 507.57, "word": " do", "probability": 0.96044921875}, {"start": 507.57, "end": 507.89, "word": " that.", "probability": 0.935546875}, {"start": 509.13, "end": 509.79, "word": " Okay.", "probability": 0.83349609375}, {"start": 510.11, "end": 510.35, "word": " So", "probability": 0.93212890625}, {"start": 510.35, "end": 510.63, "word": " going", "probability": 0.7314453125}, {"start": 510.63, "end": 510.87, "word": " to", "probability": 0.95263671875}, {"start": 510.87, "end": 511.37, "word": " refers", "probability": 0.74609375}, {"start": 511.37, "end": 511.73, "word": " to", "probability": 0.9658203125}, {"start": 511.73, "end": 512.69, "word": " intention", "probability": 0.939453125}, {"start": 512.69, "end": 513.75, "word": " and", "probability": 0.90625}, {"start": 513.75, "end": 514.71, "word": " cause.", "probability": 0.751953125}, {"start": 516.45, "end": 517.11, "word": " It", "probability": 0.5126953125}, {"start": 517.11, "end": 518.51, "word": " will", "probability": 0.8818359375}, {"start": 518.51, "end": 518.97, "word": " rain", "probability": 0.92919921875}, {"start": 518.97, "end": 520.85, "word": " soon", "probability": 0.89990234375}, {"start": 520.85, "end": 521.31, "word": " or", "probability": 0.724609375}, {"start": 521.31, "end": 521.63, "word": " it's", "probability": 0.96875}, {"start": 521.63, "end": 521.87, "word": " going", "probability": 0.951171875}, {"start": 521.87, "end": 522.07, "word": " to", "probability": 0.97265625}, {"start": 522.07, "end": 522.29, "word": " rain.", "probability": 0.9375}, {"start": 523.27, "end": 523.65, "word": " What", "probability": 0.72412109375}, {"start": 523.65, "end": 523.93, "word": " was", "probability": 0.90185546875}, {"start": 523.93, "end": 524.39, "word": " it?", "probability": 0.6943359375}, {"start": 524.39, "end": 524.59, "word": " It's", "probability": 0.950439453125}, {"start": 524.59, "end": 524.79, "word": " going", "probability": 0.93994140625}, {"start": 524.79, "end": 524.97, "word": " to", "probability": 0.9677734375}, {"start": 524.97, "end": 525.11, "word": " rain", "probability": 0.94091796875}, {"start": 525.11, "end": 525.41, "word": " because", "probability": 0.80419921875}, {"start": 525.41, "end": 525.67, "word": " we", "probability": 0.96142578125}, {"start": 525.67, "end": 526.07, "word": " have", "probability": 0.94677734375}, {"start": 526.07, "end": 527.05, "word": " cloudy", "probability": 0.94921875}, {"start": 527.05, "end": 527.37, "word": " weather.", "probability": 0.9462890625}, {"start": 527.67, "end": 527.93, "word": " So", "probability": 0.9580078125}, {"start": 527.93, "end": 528.09, "word": " we", "probability": 0.92333984375}, {"start": 528.09, "end": 528.29, "word": " have", "probability": 0.9453125}, {"start": 528.29, "end": 528.63, "word": " cause.", "probability": 0.74072265625}], "temperature": 1.0}, {"id": 23, "seek": 55862, "start": 529.72, "end": 558.62, "text": " Okay. So going to refers to cause and intention. Okay. ستمطر الدنيا حالا سيمطر الجو or yes ستمطر حالا ستمطر this is Arabic س we have the near future particle س plus the present imperfect indicative form of the verb يمطر", "tokens": [1033, 13, 407, 516, 281, 14942, 281, 3082, 293, 7789, 13, 1033, 13, 8608, 39237, 9566, 2288, 32748, 22653, 995, 11331, 6027, 995, 8608, 32640, 9566, 2288, 25724, 2407, 420, 2086, 8608, 39237, 9566, 2288, 11331, 6027, 995, 8608, 39237, 9566, 2288, 341, 307, 19938, 8608, 321, 362, 264, 2651, 2027, 12359, 8608, 1804, 264, 1974, 26714, 47513, 1254, 295, 264, 9595, 7251, 2304, 9566, 2288], "avg_logprob": -0.23460820539673763, "compression_ratio": 1.434782608695652, "no_speech_prob": 0.0, "words": [{"start": 529.72, "end": 530.02, "word": " Okay.", "probability": 0.62109375}, {"start": 530.64, "end": 530.84, "word": " So", "probability": 0.95068359375}, {"start": 530.84, "end": 531.18, "word": " going", "probability": 0.47021484375}, {"start": 531.18, "end": 531.58, "word": " to", "probability": 0.97119140625}, {"start": 531.58, "end": 533.56, "word": " refers", "probability": 0.60986328125}, {"start": 533.56, "end": 533.82, "word": " to", "probability": 0.97314453125}, {"start": 533.82, "end": 534.32, "word": " cause", "probability": 0.78369140625}, {"start": 534.32, "end": 535.6, "word": " and", "probability": 0.92236328125}, {"start": 535.6, "end": 536.4, "word": " intention.", "probability": 0.95361328125}, {"start": 537.22, "end": 537.52, "word": " Okay.", "probability": 0.837890625}, {"start": 538.54, "end": 539.2, "word": " ستمطر", "probability": 0.61322021484375}, {"start": 539.2, "end": 539.68, "word": " الدنيا", "probability": 0.9895833333333334}, {"start": 539.68, "end": 540.16, "word": " حالا", "probability": 0.8880208333333334}, {"start": 540.16, "end": 541.26, "word": " سيمطر", "probability": 0.8387451171875}, {"start": 541.26, "end": 541.82, "word": " الجو", "probability": 0.80859375}, {"start": 541.82, "end": 542.62, "word": " or", "probability": 0.2176513671875}, {"start": 542.62, "end": 544.02, "word": " yes", "probability": 0.42236328125}, {"start": 544.02, "end": 544.74, "word": " ستمطر", "probability": 0.9300537109375}, {"start": 544.74, "end": 545.26, "word": " حالا", "probability": 0.8855794270833334}, {"start": 545.26, "end": 546.64, "word": " ستمطر", "probability": 0.83905029296875}, {"start": 546.64, "end": 547.2, "word": " this", "probability": 0.433349609375}, {"start": 547.2, "end": 547.36, "word": " is", "probability": 0.9609375}, {"start": 547.36, "end": 547.88, "word": " Arabic", "probability": 0.873046875}, {"start": 547.88, "end": 548.64, "word": " س", "probability": 0.51220703125}, {"start": 548.64, "end": 549.26, "word": " we", "probability": 0.650390625}, {"start": 549.26, "end": 549.52, "word": " have", "probability": 0.9560546875}, {"start": 549.52, "end": 549.72, "word": " the", "probability": 0.92333984375}, {"start": 549.72, "end": 549.94, "word": " near", "probability": 0.9287109375}, {"start": 549.94, "end": 550.38, "word": " future", "probability": 0.96435546875}, {"start": 550.38, "end": 550.94, "word": " particle", "probability": 0.82470703125}, {"start": 550.94, "end": 551.28, "word": " س", "probability": 0.9248046875}, {"start": 551.28, "end": 552.46, "word": " plus", "probability": 0.93212890625}, {"start": 552.46, "end": 552.96, "word": " the", "probability": 0.89599609375}, {"start": 552.96, "end": 553.96, "word": " present", "probability": 0.89013671875}, {"start": 553.96, "end": 555.32, "word": " imperfect", "probability": 0.86572265625}, {"start": 555.32, "end": 556.14, "word": " indicative", "probability": 0.96044921875}, {"start": 556.14, "end": 556.68, "word": " form", "probability": 0.9296875}, {"start": 556.68, "end": 557.3, "word": " of", "probability": 0.97314453125}, {"start": 557.3, "end": 557.44, "word": " the", "probability": 0.93408203125}, {"start": 557.44, "end": 557.76, "word": " verb", "probability": 0.9111328125}, {"start": 557.76, "end": 558.62, "word": " يمطر", "probability": 0.9674072265625}], "temperature": 1.0}, {"id": 24, "seek": 57979, "start": 559.52, "end": 579.8, "text": " Not amtara, yumtara. About to. We are about to start explaining the rest of the lecture about futurity. We're about to leave. We are about to quit.", "tokens": [1726, 669, 83, 2419, 11, 26420, 83, 2419, 13, 7769, 281, 13, 492, 366, 466, 281, 722, 13468, 264, 1472, 295, 264, 7991, 466, 1877, 3051, 13, 492, 434, 466, 281, 1856, 13, 492, 366, 466, 281, 10366, 13], "avg_logprob": -0.19599610045552254, "compression_ratio": 1.4230769230769231, "no_speech_prob": 0.0, "words": [{"start": 559.52, "end": 559.8, "word": " Not", "probability": 0.4853515625}, {"start": 559.8, "end": 560.4, "word": " amtara,", "probability": 0.5677083333333334}, {"start": 560.92, "end": 561.38, "word": " yumtara.", "probability": 0.55908203125}, {"start": 562.88, "end": 563.18, "word": " About", "probability": 0.75146484375}, {"start": 563.18, "end": 563.54, "word": " to.", "probability": 0.91552734375}, {"start": 565.16, "end": 565.38, "word": " We", "probability": 0.84423828125}, {"start": 565.38, "end": 565.82, "word": " are", "probability": 0.939453125}, {"start": 565.82, "end": 566.28, "word": " about", "probability": 0.90771484375}, {"start": 566.28, "end": 567.48, "word": " to", "probability": 0.9716796875}, {"start": 567.48, "end": 568.98, "word": " start", "probability": 0.923828125}, {"start": 568.98, "end": 571.06, "word": " explaining", "probability": 0.8447265625}, {"start": 571.06, "end": 572.76, "word": " the", "probability": 0.90673828125}, {"start": 572.76, "end": 573.1, "word": " rest", "probability": 0.935546875}, {"start": 573.1, "end": 573.42, "word": " of", "probability": 0.970703125}, {"start": 573.42, "end": 573.56, "word": " the", "probability": 0.9228515625}, {"start": 573.56, "end": 573.98, "word": " lecture", "probability": 0.953125}, {"start": 573.98, "end": 574.78, "word": " about", "probability": 0.740234375}, {"start": 574.78, "end": 575.44, "word": " futurity.", "probability": 0.88671875}, {"start": 576.22, "end": 576.62, "word": " We're", "probability": 0.835693359375}, {"start": 576.62, "end": 576.98, "word": " about", "probability": 0.90576171875}, {"start": 576.98, "end": 577.24, "word": " to", "probability": 0.9697265625}, {"start": 577.24, "end": 577.56, "word": " leave.", "probability": 0.96337890625}, {"start": 578.38, "end": 578.68, "word": " We", "probability": 0.96728515625}, {"start": 578.68, "end": 578.84, "word": " are", "probability": 0.87451171875}, {"start": 578.84, "end": 579.2, "word": " about", "probability": 0.9091796875}, {"start": 579.2, "end": 579.44, "word": " to", "probability": 0.970703125}, {"start": 579.44, "end": 579.8, "word": " quit.", "probability": 0.9208984375}], "temperature": 1.0}, {"id": 25, "seek": 60973, "start": 580.79, "end": 609.73, "text": " Okay, we are about to quit about to على وشك We have the same equivalent in Arabic على وشك أن أبدأ المحاضرة على وشك أن نبدأ المحاضرة على وشك بدء المحاضرة نحن على وشك بدء المحاضرة is accepted. So we have So we have على وشك أن نبدأ Okay this refers to imminent future", "tokens": [1033, 11, 321, 366, 466, 281, 10366, 466, 281, 15844, 4032, 8592, 4117, 492, 362, 264, 912, 10344, 294, 19938, 15844, 4032, 8592, 4117, 14739, 5551, 44510, 10721, 9673, 5016, 46958, 25720, 15844, 4032, 8592, 4117, 14739, 8717, 44510, 10721, 9673, 5016, 46958, 25720, 15844, 4032, 8592, 4117, 47525, 38207, 9673, 5016, 46958, 25720, 8717, 5016, 1863, 15844, 4032, 8592, 4117, 47525, 38207, 9673, 5016, 46958, 25720, 307, 9035, 13, 407, 321, 362, 407, 321, 362, 15844, 4032, 8592, 4117, 14739, 8717, 44510, 10721, 1033, 341, 14942, 281, 44339, 2027], "avg_logprob": -0.18732829244582208, "compression_ratio": 1.9565217391304348, "no_speech_prob": 0.0, "words": [{"start": 580.79, "end": 581.15, "word": " Okay,", "probability": 0.59619140625}, {"start": 581.69, "end": 581.83, "word": " we", "probability": 0.85302734375}, {"start": 581.83, "end": 581.91, "word": " are", "probability": 0.70556640625}, {"start": 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Okay. Very near future. Imminent future. Okay. The taxi is there at the gate and we are about to leave. The taxi is there at the gate and we are about to leave. Okay. After a few minutes, about to leave. We have about plus the infinitive in English. 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"end": 664.57, "word": " covert", "probability": 0.72412109375}, {"start": 664.57, "end": 665.49, "word": " derived", "probability": 0.87109375}, {"start": 665.49, "end": 665.91, "word": " nominal", "probability": 0.955078125}, {"start": 665.91, "end": 666.85, "word": " طب", "probability": 0.7724609375}, {"start": 666.85, "end": 667.27, "word": " نحن", "probability": 0.9287109375}, {"start": 667.27, "end": 667.49, "word": " على", "probability": 0.966796875}, {"start": 667.49, "end": 667.93, "word": " وشك", "probability": 0.9982096354166666}, {"start": 667.93, "end": 668.61, "word": " المغادرة", "probability": 0.98876953125}], "temperature": 1.0}, {"id": 28, "seek": 67524, "start": 671.12, "end": 675.24, "text": " Overt derived nominal okay", "tokens": [422, 3281, 18949, 41641, 1392], "avg_logprob": -0.910156269868215, "compression_ratio": 0.7714285714285715, "no_speech_prob": 0.0, "words": [{"start": 671.12, "end": 672.52, "word": " Overt", "probability": 0.435943603515625}, {"start": 672.52, "end": 673.16, "word": " derived", "probability": 0.359619140625}, {"start": 673.16, "end": 673.54, "word": " nominal", "probability": 0.9443359375}, {"start": 673.54, "end": 675.24, "word": " okay", "probability": 0.32861328125}], "temperature": 1.0}, {"id": 29, "seek": 73214, "start": 702.88, "end": 732.14, "text": " We spoke about the present simple denoting future and present progressive denoting future as well. Sheikh? Okay. He leaves for Egypt tomorrow. She arrives by ten o'clock train this evening. So we have the present simple denoting future if we have a plan or program.", "tokens": [492, 7179, 466, 264, 1974, 2199, 1441, 17001, 2027, 293, 1974, 16131, 1441, 17001, 2027, 382, 731, 13, 46160, 30, 1033, 13, 634, 5510, 337, 9582, 4153, 13, 1240, 20116, 538, 2064, 277, 6, 9023, 3847, 341, 5634, 13, 407, 321, 362, 264, 1974, 2199, 1441, 17001, 2027, 498, 321, 362, 257, 1393, 420, 1461, 13], "avg_logprob": -0.17859100458914773, "compression_ratio": 1.6521739130434783, "no_speech_prob": 0.0, "words": [{"start": 702.88, "end": 703.14, "word": " We", "probability": 0.771484375}, {"start": 703.14, "end": 703.44, "word": " spoke", "probability": 0.87451171875}, {"start": 703.44, "end": 703.7, "word": " about", "probability": 0.9091796875}, {"start": 703.7, "end": 703.88, "word": " the", "probability": 0.87841796875}, {"start": 703.88, "end": 704.16, "word": " present", "probability": 0.87109375}, {"start": 704.16, "end": 704.66, "word": " simple", "probability": 0.876953125}, {"start": 704.66, "end": 705.1, "word": " denoting", "probability": 0.90625}, {"start": 705.1, "end": 705.6, "word": " future", "probability": 0.96875}, {"start": 705.6, "end": 705.86, "word": " and", "probability": 0.87109375}, {"start": 705.86, "end": 706.16, "word": " present", "probability": 0.9248046875}, {"start": 706.16, "end": 706.84, "word": " progressive", "probability": 0.80224609375}, {"start": 706.84, "end": 707.9, "word": " denoting", "probability": 0.936279296875}, {"start": 707.9, "end": 708.38, "word": " future", "probability": 0.9736328125}, {"start": 708.38, "end": 708.58, "word": " as", "probability": 0.916015625}, {"start": 708.58, "end": 708.84, "word": " well.", "probability": 0.94482421875}, {"start": 709.96, "end": 710.24, "word": " Sheikh?", "probability": 0.31884765625}, {"start": 718.04, "end": 718.78, "word": " Okay.", "probability": 0.52001953125}, {"start": 719.6, "end": 719.86, "word": " He", "probability": 0.85107421875}, {"start": 719.86, "end": 720.26, "word": " leaves", "probability": 0.86572265625}, {"start": 720.26, "end": 720.74, "word": " for", "probability": 0.76513671875}, {"start": 720.74, "end": 721.1, "word": " Egypt", "probability": 0.93212890625}, {"start": 721.1, "end": 721.58, "word": " tomorrow.", "probability": 0.875}, {"start": 723.0, "end": 723.16, "word": " She", "probability": 0.8916015625}, {"start": 723.16, "end": 723.6, "word": " arrives", "probability": 0.89697265625}, {"start": 723.6, "end": 723.84, "word": " by", "probability": 0.96826171875}, {"start": 723.84, "end": 724.12, "word": " ten", "probability": 0.465087890625}, {"start": 724.12, "end": 724.3, "word": " o", "probability": 0.83056640625}, {"start": 724.3, "end": 724.42, "word": "'clock", "probability": 0.933837890625}, {"start": 724.42, "end": 724.82, "word": " train", "probability": 0.93896484375}, {"start": 724.82, "end": 725.26, "word": " this", "probability": 0.93798828125}, {"start": 725.26, "end": 725.72, "word": " evening.", "probability": 0.92919921875}, {"start": 726.4, "end": 726.98, "word": " So", "probability": 0.93994140625}, {"start": 726.98, "end": 727.12, "word": " we", "probability": 0.74072265625}, {"start": 727.12, "end": 727.46, "word": " have", "probability": 0.9521484375}, {"start": 727.46, "end": 727.7, "word": " the", "probability": 0.63427734375}, {"start": 727.7, "end": 727.96, "word": " present", "probability": 0.92822265625}, {"start": 727.96, "end": 728.48, "word": " simple", "probability": 0.9287109375}, {"start": 728.48, "end": 729.16, "word": " denoting", "probability": 0.871337890625}, {"start": 729.16, "end": 729.66, "word": " future", "probability": 0.97705078125}, {"start": 729.66, "end": 729.94, "word": " if", "probability": 0.81591796875}, {"start": 729.94, "end": 730.08, "word": " we", "probability": 0.9541015625}, {"start": 730.08, "end": 730.26, "word": " have", "probability": 0.94921875}, {"start": 730.26, "end": 730.4, "word": " a", "probability": 0.994140625}, {"start": 730.4, "end": 730.76, "word": " plan", "probability": 0.962890625}, {"start": 730.76, "end": 731.2, "word": " or", "probability": 0.95068359375}, {"start": 731.2, "end": 732.14, "word": " program.", "probability": 0.79931640625}], "temperature": 1.0}, {"id": 30, "seek": 75685, "start": 732.95, "end": 756.85, "text": " or a timetable. We have this also available in Arabic. سأسافر عندما يأتي أحمد. We mentioned that we have the present simple just in the structure of adverbial clauses of time and condition. This is what we mentioned in the last lecture. Okay.", "tokens": [420, 257, 524, 302, 712, 13, 492, 362, 341, 611, 2435, 294, 19938, 13, 8608, 10721, 3794, 31845, 2288, 43242, 15042, 7251, 10721, 31371, 5551, 35571, 3215, 13, 492, 2835, 300, 321, 362, 264, 1974, 2199, 445, 294, 264, 3877, 295, 614, 25809, 831, 49072, 295, 565, 293, 4188, 13, 639, 307, 437, 321, 2835, 294, 264, 1036, 7991, 13, 1033, 13], "avg_logprob": -0.19419642667921763, "compression_ratio": 1.3717277486910995, "no_speech_prob": 0.0, "words": [{"start": 732.95, "end": 733.19, "word": " or", "probability": 0.476318359375}, {"start": 733.19, "end": 733.35, "word": " a", "probability": 0.47265625}, {"start": 733.35, "end": 733.85, "word": " timetable.", "probability": 0.9591471354166666}, {"start": 734.71, "end": 734.81, "word": " We", "probability": 0.80810546875}, {"start": 734.81, "end": 734.99, "word": " have", "probability": 0.947265625}, {"start": 734.99, "end": 736.65, "word": " this", "probability": 0.4541015625}, {"start": 736.65, "end": 737.13, "word": " also", "probability": 0.84765625}, {"start": 737.13, "end": 737.63, "word": " available", "probability": 0.83544921875}, {"start": 737.63, "end": 738.03, "word": " in", "probability": 0.95166015625}, {"start": 738.03, "end": 738.57, "word": " Arabic.", "probability": 0.9111328125}, {"start": 740.45, "end": 741.25, "word": " سأسافر", "probability": 0.8072265625}, {"start": 741.25, "end": 742.35, "word": " عندما", "probability": 0.9541015625}, {"start": 742.35, "end": 742.91, "word": " يأتي", "probability": 0.9601236979166666}, {"start": 742.91, "end": 743.65, "word": " أحمد.", "probability": 0.8134765625}, {"start": 744.03, "end": 744.73, "word": " We", "probability": 0.8662109375}, {"start": 744.73, "end": 745.11, "word": " mentioned", "probability": 0.76953125}, {"start": 745.11, "end": 745.39, "word": " that", "probability": 0.935546875}, {"start": 745.39, "end": 745.57, "word": " we", "probability": 0.95654296875}, {"start": 745.57, "end": 745.87, "word": " have", "probability": 0.9501953125}, {"start": 745.87, "end": 746.05, "word": " the", "probability": 0.8857421875}, {"start": 746.05, "end": 746.33, "word": " present", "probability": 0.91064453125}, {"start": 746.33, "end": 746.85, "word": " simple", "probability": 0.9560546875}, {"start": 746.85, "end": 747.99, "word": " just", "probability": 0.7314453125}, {"start": 747.99, "end": 748.27, "word": " in", "probability": 0.94140625}, {"start": 748.27, "end": 748.41, "word": " the", "probability": 0.9208984375}, {"start": 748.41, "end": 748.83, "word": " structure", "probability": 0.86865234375}, {"start": 748.83, "end": 749.27, "word": " of", "probability": 0.96923828125}, {"start": 749.27, "end": 750.01, "word": " adverbial", "probability": 0.8932291666666666}, {"start": 750.01, "end": 750.41, "word": " clauses", "probability": 0.88330078125}, {"start": 750.41, "end": 750.87, "word": " of", "probability": 0.96240234375}, {"start": 750.87, "end": 751.33, "word": " time", "probability": 0.88525390625}, {"start": 751.33, "end": 751.97, "word": " and", "probability": 0.9462890625}, {"start": 751.97, "end": 752.45, "word": " condition.", "probability": 0.947265625}, {"start": 753.81, "end": 754.09, "word": " This", "probability": 0.84814453125}, {"start": 754.09, "end": 754.17, "word": " is", "probability": 0.8935546875}, {"start": 754.17, "end": 754.29, "word": " what", "probability": 0.94775390625}, {"start": 754.29, "end": 754.43, "word": " we", "probability": 0.9619140625}, {"start": 754.43, "end": 754.75, "word": " mentioned", "probability": 0.84130859375}, {"start": 754.75, "end": 755.01, "word": " in", "probability": 0.669921875}, {"start": 755.01, "end": 755.17, "word": " the", "probability": 0.599609375}, {"start": 755.17, "end": 755.43, "word": " last", "probability": 0.86376953125}, {"start": 755.43, "end": 755.85, "word": " lecture.", "probability": 0.9453125}, {"start": 756.57, "end": 756.85, "word": " Okay.", "probability": 0.783203125}], "temperature": 1.0}, {"id": 31, "seek": 78756, "start": 758.58, "end": 787.56, "text": " سو سافر عندما يأتي أحمد. I'll travel when Ahmed comes. When Ahmed comes. Don't say when Ahmed came or will come. It's wrong. Once Ahmed comes. Okay. What do you say if I stay here for another two hours? What do you say if I stay?", "tokens": [8608, 2407, 8608, 31845, 2288, 43242, 15042, 7251, 10721, 31371, 5551, 35571, 3215, 13, 286, 603, 3147, 562, 39189, 1487, 13, 1133, 39189, 1487, 13, 1468, 380, 584, 562, 39189, 1361, 420, 486, 808, 13, 467, 311, 2085, 13, 3443, 39189, 1487, 13, 1033, 13, 708, 360, 291, 584, 498, 286, 1754, 510, 337, 1071, 732, 2496, 30, 708, 360, 291, 584, 498, 286, 1754, 30], "avg_logprob": -0.18831622422631109, "compression_ratio": 1.447674418604651, "no_speech_prob": 0.0, "words": [{"start": 758.58, "end": 758.96, "word": " سو", "probability": 0.39453125}, {"start": 758.96, "end": 759.42, "word": " سافر", "probability": 0.9842122395833334}, {"start": 759.42, "end": 759.86, "word": " عندما", "probability": 0.9658203125}, {"start": 759.86, "end": 760.34, "word": " يأتي", "probability": 0.95458984375}, {"start": 760.34, "end": 760.86, "word": " أحمد.", "probability": 0.8606770833333334}, {"start": 761.0, "end": 761.54, "word": " I'll", "probability": 0.70751953125}, {"start": 761.54, "end": 761.88, "word": " travel", "probability": 0.8662109375}, {"start": 761.88, "end": 762.54, "word": " when", "probability": 0.931640625}, {"start": 762.54, "end": 763.22, "word": " Ahmed", "probability": 0.4638671875}, {"start": 763.22, "end": 764.36, "word": " comes.", "probability": 0.6650390625}, {"start": 765.94, "end": 766.3, "word": " When", "probability": 0.58984375}, {"start": 766.3, "end": 766.78, "word": " Ahmed", "probability": 0.81591796875}, {"start": 766.78, "end": 767.32, "word": " comes.", "probability": 0.85986328125}, {"start": 767.82, "end": 768.12, "word": " Don't", "probability": 0.914306640625}, {"start": 768.12, "end": 768.38, "word": " say", "probability": 0.951171875}, {"start": 768.38, "end": 768.6, "word": " when", "probability": 0.8134765625}, {"start": 768.6, "end": 768.92, "word": " Ahmed", "probability": 0.8681640625}, {"start": 768.92, "end": 769.34, "word": " came", "probability": 0.84912109375}, {"start": 769.34, "end": 770.46, "word": " or", "probability": 0.837890625}, {"start": 770.46, "end": 770.82, "word": " will", "probability": 0.865234375}, {"start": 770.82, "end": 771.24, "word": " come.", "probability": 0.89794921875}, {"start": 771.52, "end": 771.78, "word": " It's", "probability": 0.95703125}, {"start": 771.78, "end": 772.14, "word": " wrong.", "probability": 0.939453125}, {"start": 772.86, "end": 773.22, "word": " Once", "probability": 0.88671875}, {"start": 773.22, "end": 773.68, "word": " Ahmed", "probability": 0.87646484375}, {"start": 773.68, "end": 774.58, "word": " comes.", "probability": 0.859375}, {"start": 775.78, "end": 776.22, "word": " Okay.", "probability": 0.75537109375}, {"start": 777.52, "end": 778.36, "word": " What", "probability": 0.90234375}, {"start": 778.36, "end": 778.48, "word": " do", "probability": 0.96484375}, {"start": 778.48, "end": 778.62, "word": " you", "probability": 0.96875}, {"start": 778.62, "end": 778.88, "word": " say", "probability": 0.953125}, {"start": 778.88, "end": 779.18, "word": " if", "probability": 0.9287109375}, {"start": 779.18, "end": 779.4, "word": " I", "probability": 0.998046875}, {"start": 779.4, "end": 779.72, "word": " stay", "probability": 0.9755859375}, {"start": 779.72, "end": 780.18, "word": " here", "probability": 0.85595703125}, {"start": 780.18, "end": 781.94, "word": " for", "probability": 0.92431640625}, {"start": 781.94, "end": 782.36, "word": " another", "probability": 0.9228515625}, {"start": 782.36, "end": 782.6, "word": " two", "probability": 0.90673828125}, {"start": 782.6, "end": 783.0, "word": " hours?", "probability": 0.9208984375}, {"start": 784.76, "end": 785.6, "word": " What", "probability": 0.88671875}, {"start": 785.6, "end": 785.7, "word": " do", "probability": 0.9619140625}, {"start": 785.7, "end": 785.82, "word": " you", "probability": 0.96533203125}, {"start": 785.82, "end": 786.1, "word": " say", "probability": 0.95068359375}, {"start": 786.1, "end": 786.92, "word": " if", "probability": 0.896484375}, {"start": 786.92, "end": 787.18, "word": " I", "probability": 0.998046875}, {"start": 787.18, "end": 787.56, "word": " stay?", "probability": 0.95947265625}], "temperature": 1.0}, {"id": 32, "seek": 80941, "start": 789.79, "end": 809.41, "text": " What will you say if I stay? So the conditional clause also contains the present simple which refers to future action. We have present continuous as well.", "tokens": [708, 486, 291, 584, 498, 286, 1754, 30, 407, 264, 27708, 25925, 611, 8306, 264, 1974, 2199, 597, 14942, 281, 2027, 3069, 13, 492, 362, 1974, 10957, 382, 731, 13], "avg_logprob": -0.14226311156826635, "compression_ratio": 1.3135593220338984, "no_speech_prob": 0.0, "words": [{"start": 789.79, "end": 790.53, "word": " What", "probability": 0.73388671875}, {"start": 790.53, "end": 790.79, "word": " will", "probability": 0.861328125}, {"start": 790.79, "end": 790.99, "word": " you", "probability": 0.9697265625}, {"start": 790.99, "end": 791.29, "word": " say", "probability": 0.95556640625}, {"start": 791.29, "end": 791.67, "word": " if", "probability": 0.93310546875}, {"start": 791.67, "end": 791.97, "word": " I", "probability": 0.9873046875}, {"start": 791.97, "end": 792.29, "word": " stay?", "probability": 0.485107421875}, {"start": 793.15, "end": 793.31, "word": " So", "probability": 0.79638671875}, {"start": 793.31, "end": 793.65, "word": " the", "probability": 0.689453125}, {"start": 793.65, "end": 794.15, "word": " conditional", "probability": 0.84619140625}, {"start": 794.15, "end": 794.67, "word": " clause", "probability": 0.95361328125}, {"start": 794.67, "end": 795.69, "word": " also", "probability": 0.8544921875}, {"start": 795.69, "end": 796.29, "word": " contains", "probability": 0.90283203125}, {"start": 796.29, "end": 796.51, "word": " the", "probability": 0.91162109375}, {"start": 796.51, "end": 796.79, "word": " present", "probability": 0.89697265625}, {"start": 796.79, "end": 797.23, "word": " simple", "probability": 0.9306640625}, {"start": 797.23, "end": 797.51, "word": " which", "probability": 0.74658203125}, {"start": 797.51, "end": 798.31, "word": " refers", "probability": 0.8154296875}, {"start": 798.31, "end": 798.67, "word": " to", "probability": 0.96630859375}, {"start": 798.67, "end": 799.71, "word": " future", "probability": 0.97802734375}, {"start": 799.71, "end": 800.15, "word": " action.", "probability": 0.947265625}, {"start": 806.93, "end": 807.67, "word": " We", "probability": 0.93115234375}, {"start": 807.67, "end": 807.89, "word": " have", "probability": 0.9541015625}, {"start": 807.89, "end": 808.25, "word": " present", "probability": 0.943359375}, {"start": 808.25, "end": 808.77, "word": " continuous", "probability": 0.80615234375}, {"start": 808.77, "end": 809.19, "word": " as", "probability": 0.96923828125}, {"start": 809.19, "end": 809.41, "word": " well.", "probability": 0.94873046875}], "temperature": 1.0}, {"id": 33, "seek": 83934, "start": 811.18, "end": 839.34, "text": " which refers to an action that has been planned for the future. I'm traveling by seven o'clock flight to Egypt this evening. I'm taking the children to the seashore tomorrow evening. Okay, so we have plan or timetable program. Okay, we have this in Arabic. أنا قادم لزيارتكم اليوم.", "tokens": [597, 14942, 281, 364, 3069, 300, 575, 668, 8589, 337, 264, 2027, 13, 286, 478, 9712, 538, 3407, 277, 6, 9023, 7018, 281, 9582, 341, 5634, 13, 286, 478, 1940, 264, 2227, 281, 264, 369, 1299, 418, 4153, 5634, 13, 1033, 11, 370, 321, 362, 1393, 420, 524, 302, 712, 1461, 13, 1033, 11, 321, 362, 341, 294, 19938, 13, 41850, 12174, 18513, 2304, 5296, 11622, 1829, 9640, 2655, 24793, 45595, 20498, 13], "avg_logprob": -0.16078969997328682, "compression_ratio": 1.3542600896860986, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 811.18, "end": 811.48, "word": " which", "probability": 0.52685546875}, {"start": 811.48, "end": 811.98, "word": " refers", "probability": 0.85546875}, {"start": 811.98, "end": 812.52, "word": " to", "probability": 0.96875}, {"start": 812.52, "end": 812.76, "word": " an", "probability": 0.958984375}, {"start": 812.76, "end": 813.08, "word": " action", "probability": 0.94873046875}, {"start": 813.08, "end": 813.32, "word": " that", "probability": 0.93603515625}, {"start": 813.32, "end": 813.58, "word": " has", "probability": 0.94189453125}, {"start": 813.58, "end": 813.86, "word": " been", "probability": 0.9140625}, {"start": 813.86, "end": 814.36, "word": " planned", "probability": 0.89453125}, {"start": 814.36, "end": 815.06, "word": " for", "probability": 0.9521484375}, {"start": 815.06, "end": 815.28, "word": " the", "probability": 0.91845703125}, {"start": 815.28, "end": 815.74, "word": " future.", "probability": 0.9775390625}, {"start": 816.44, "end": 816.62, "word": " I'm", "probability": 0.893310546875}, {"start": 816.62, "end": 817.04, "word": " traveling", "probability": 0.68310546875}, {"start": 817.04, "end": 817.42, "word": " by", "probability": 0.9736328125}, {"start": 817.42, "end": 817.8, "word": " seven", "probability": 0.7001953125}, {"start": 817.8, "end": 818.14, "word": " o", "probability": 0.88427734375}, {"start": 818.14, "end": 818.16, "word": "'clock", "probability": 0.95068359375}, {"start": 818.16, "end": 818.7, "word": " flight", "probability": 0.86083984375}, {"start": 818.7, "end": 819.34, "word": " to", "probability": 0.9560546875}, {"start": 819.34, "end": 819.68, "word": " Egypt", "probability": 0.92333984375}, {"start": 819.68, "end": 820.0, "word": " this", "probability": 0.93505859375}, {"start": 820.0, "end": 820.38, "word": " evening.", "probability": 0.921875}, {"start": 821.6, "end": 822.36, "word": " I'm", "probability": 0.982666015625}, {"start": 822.36, "end": 822.68, "word": " taking", "probability": 0.9072265625}, {"start": 822.68, "end": 822.88, "word": " the", "probability": 0.71630859375}, {"start": 822.88, "end": 823.16, "word": " children", "probability": 0.849609375}, {"start": 823.16, "end": 823.46, "word": " to", "probability": 0.96630859375}, {"start": 823.46, "end": 823.64, "word": " the", "probability": 0.92236328125}, {"start": 823.64, "end": 824.14, "word": " seashore", "probability": 0.82421875}, {"start": 824.14, "end": 824.62, "word": " tomorrow", "probability": 0.8779296875}, {"start": 824.62, "end": 825.28, "word": " evening.", "probability": 0.91845703125}, {"start": 827.7, "end": 828.08, "word": " Okay,", "probability": 0.62939453125}, {"start": 828.68, "end": 829.74, "word": " so", "probability": 0.9345703125}, {"start": 829.74, "end": 829.9, "word": " we", "probability": 0.94189453125}, {"start": 829.9, "end": 830.06, "word": " have", "probability": 0.9482421875}, {"start": 830.06, "end": 830.48, "word": " plan", "probability": 0.58447265625}, {"start": 830.48, "end": 831.6, "word": " or", "probability": 0.73828125}, {"start": 831.6, "end": 832.34, "word": " timetable", "probability": 0.9611002604166666}, {"start": 832.34, "end": 832.94, "word": " program.", "probability": 0.87255859375}, {"start": 834.48, "end": 834.76, "word": " Okay,", "probability": 0.84033203125}, {"start": 835.12, "end": 835.38, "word": " we", "probability": 0.9599609375}, {"start": 835.38, "end": 835.56, "word": " have", "probability": 0.94580078125}, {"start": 835.56, "end": 835.84, "word": " this", "probability": 0.94970703125}, {"start": 835.84, "end": 836.08, "word": " in", "probability": 0.9521484375}, {"start": 836.08, "end": 836.52, "word": " Arabic.", "probability": 0.90673828125}, {"start": 837.22, "end": 837.36, "word": " أنا", "probability": 0.185791015625}, {"start": 837.36, "end": 837.96, "word": " قادم", "probability": 0.9261067708333334}, {"start": 837.96, "end": 838.92, "word": " لزيارتكم", "probability": 0.9464518229166666}, {"start": 838.92, "end": 839.34, "word": " اليوم.", "probability": 0.99267578125}], "temperature": 1.0}, {"id": 34, "seek": 86525, "start": 840.47, "end": 865.25, "text": " أنا قادم. What do you say about قادم? This is nominal subject. اسم الفاعل. Okay. We mentioned going to, I'm going to. So we have there to be M is R plus going to infinitive. Okay. She's going to get married.", "tokens": [41850, 12174, 18513, 2304, 13, 708, 360, 291, 584, 466, 12174, 18513, 2304, 30, 639, 307, 41641, 3983, 13, 24525, 2304, 27188, 995, 30241, 13, 1033, 13, 492, 2835, 516, 281, 11, 286, 478, 516, 281, 13, 407, 321, 362, 456, 281, 312, 376, 307, 497, 1804, 516, 281, 7193, 2187, 13, 1033, 13, 1240, 311, 516, 281, 483, 5259, 13], "avg_logprob": -0.2442036348004495, "compression_ratio": 1.2954545454545454, "no_speech_prob": 0.0, "words": [{"start": 840.47, "end": 840.79, "word": " أنا", "probability": 0.06982421875}, {"start": 840.79, "end": 841.33, "word": " قادم.", "probability": 0.98681640625}, {"start": 841.93, "end": 842.43, "word": " What", "probability": 0.7939453125}, {"start": 842.43, "end": 842.53, "word": " do", "probability": 0.93505859375}, {"start": 842.53, "end": 842.61, "word": " you", "probability": 0.962890625}, {"start": 842.61, "end": 842.73, "word": " say", "probability": 0.888671875}, {"start": 842.73, "end": 843.03, "word": " about", "probability": 0.9326171875}, {"start": 843.03, "end": 843.47, "word": " قادم?", "probability": 0.8977864583333334}, {"start": 844.65, "end": 845.33, "word": " This", "probability": 0.6142578125}, {"start": 845.33, "end": 845.49, "word": " is", "probability": 0.939453125}, {"start": 845.49, "end": 845.69, "word": " nominal", "probability": 0.921875}, {"start": 845.69, "end": 846.43, "word": " subject.", "probability": 0.97265625}, {"start": 846.67, "end": 846.89, "word": " اسم", "probability": 0.75732421875}, {"start": 846.89, "end": 847.41, "word": " الفاعل.", "probability": 0.8302408854166666}, {"start": 848.19, "end": 848.45, "word": " Okay.", "probability": 0.72314453125}, {"start": 852.49, "end": 853.17, "word": " We", "probability": 0.93359375}, {"start": 853.17, "end": 853.65, "word": " mentioned", "probability": 0.80419921875}, {"start": 853.65, "end": 854.95, "word": " going", "probability": 0.90966796875}, {"start": 854.95, "end": 855.35, "word": " to,", "probability": 0.978515625}, {"start": 856.03, "end": 856.25, "word": " I'm", "probability": 0.80517578125}, {"start": 856.25, "end": 856.61, "word": " going", "probability": 0.9560546875}, {"start": 856.61, "end": 856.91, "word": " to.", "probability": 0.96435546875}, {"start": 857.07, "end": 857.17, "word": " So", "probability": 0.94140625}, {"start": 857.17, "end": 857.33, "word": " we", "probability": 0.8740234375}, {"start": 857.33, "end": 857.59, "word": " have", "probability": 0.94775390625}, {"start": 857.59, "end": 857.83, "word": " there", "probability": 0.83154296875}, {"start": 857.83, "end": 857.99, "word": " to", "probability": 0.978515625}, {"start": 857.99, "end": 858.29, "word": " be", "probability": 0.96240234375}, {"start": 858.29, "end": 858.79, "word": " M", "probability": 0.448974609375}, {"start": 858.79, "end": 859.15, "word": " is", "probability": 0.8837890625}, {"start": 859.15, "end": 859.49, "word": " R", "probability": 0.80615234375}, {"start": 859.49, "end": 859.79, "word": " plus", "probability": 0.87744140625}, {"start": 859.79, "end": 860.35, "word": " going", "probability": 0.9482421875}, {"start": 860.35, "end": 861.61, "word": " to", "probability": 0.9609375}, {"start": 861.61, "end": 862.63, "word": " infinitive.", "probability": 0.79736328125}, {"start": 863.23, "end": 863.57, "word": " Okay.", "probability": 0.83154296875}, {"start": 863.97, "end": 864.27, "word": " She's", "probability": 0.8896484375}, {"start": 864.27, "end": 864.49, "word": " going", "probability": 0.9501953125}, {"start": 864.49, "end": 864.65, "word": " to", "probability": 0.97216796875}, {"start": 864.65, "end": 864.87, "word": " get", "probability": 0.9482421875}, {"start": 864.87, "end": 865.25, "word": " married.", "probability": 0.90966796875}], "temperature": 1.0}, {"id": 35, "seek": 89626, "start": 867.0, "end": 896.26, "text": " We have cause. Okay. There is an engagement that is followed by marriage. Julie is going to have a baby. So we have causes. I'm going to attend Ahmed's party. This is intention. Okay. Be about to. The taxi is there at the gate and we are about to leave.", "tokens": [492, 362, 3082, 13, 1033, 13, 821, 307, 364, 8742, 300, 307, 6263, 538, 7194, 13, 18794, 307, 516, 281, 362, 257, 3186, 13, 407, 321, 362, 7700, 13, 286, 478, 516, 281, 6888, 39189, 311, 3595, 13, 639, 307, 7789, 13, 1033, 13, 879, 466, 281, 13, 440, 18984, 307, 456, 412, 264, 8539, 293, 321, 366, 466, 281, 1856, 13], "avg_logprob": -0.13950892384090122, "compression_ratio": 1.5301204819277108, "no_speech_prob": 0.0, "words": [{"start": 867.0, "end": 867.2, "word": " We", "probability": 0.7939453125}, {"start": 867.2, "end": 867.46, "word": " have", "probability": 0.9384765625}, {"start": 867.46, "end": 867.86, "word": " cause.", "probability": 0.3017578125}, {"start": 868.78, "end": 869.0, "word": " Okay.", "probability": 0.6962890625}, {"start": 869.1, "end": 869.22, "word": " There", "probability": 0.67822265625}, {"start": 869.22, "end": 869.36, "word": " is", "probability": 0.9140625}, {"start": 869.36, "end": 869.56, "word": " an", "probability": 0.95751953125}, {"start": 869.56, "end": 870.08, "word": " engagement", "probability": 0.8046875}, {"start": 870.08, "end": 870.98, "word": " that", "probability": 0.90283203125}, {"start": 870.98, "end": 871.2, "word": " is", "probability": 0.9375}, {"start": 871.2, "end": 871.44, "word": " followed", "probability": 0.89697265625}, {"start": 871.44, "end": 871.84, "word": " by", "probability": 0.9755859375}, {"start": 871.84, "end": 873.2, "word": " marriage.", "probability": 0.91796875}, {"start": 873.76, "end": 874.06, "word": " Julie", "probability": 0.84228515625}, {"start": 874.06, "end": 874.32, "word": " is", "probability": 0.9326171875}, {"start": 874.32, "end": 874.48, "word": " going", "probability": 0.947265625}, {"start": 874.48, "end": 874.66, "word": " to", "probability": 0.96923828125}, {"start": 874.66, "end": 874.86, "word": " have", "probability": 0.94873046875}, {"start": 874.86, "end": 875.04, "word": " a", "probability": 0.99755859375}, {"start": 875.04, "end": 875.34, "word": " baby.", "probability": 0.92041015625}, {"start": 875.88, "end": 876.08, "word": " So", "probability": 0.95849609375}, {"start": 876.08, "end": 876.26, "word": " we", "probability": 0.8662109375}, {"start": 876.26, "end": 876.68, "word": " have", "probability": 0.94775390625}, {"start": 876.68, "end": 877.5, "word": " causes.", "probability": 0.86572265625}, {"start": 878.94, "end": 879.54, "word": " I'm", "probability": 0.925048828125}, {"start": 879.54, "end": 879.74, "word": " going", "probability": 0.94384765625}, {"start": 879.74, "end": 879.98, "word": " to", "probability": 0.97265625}, {"start": 879.98, "end": 880.46, "word": " attend", "probability": 0.89990234375}, {"start": 880.46, "end": 881.1, "word": " Ahmed's", "probability": 0.780029296875}, {"start": 881.1, "end": 881.54, "word": " party.", "probability": 0.89111328125}, {"start": 881.96, "end": 882.16, "word": " This", "probability": 0.8974609375}, {"start": 882.16, "end": 882.42, "word": " is", "probability": 0.943359375}, {"start": 882.42, "end": 882.96, "word": " intention.", "probability": 0.76318359375}, {"start": 884.4, "end": 884.56, "word": " Okay.", "probability": 0.78662109375}, {"start": 890.38, "end": 890.78, "word": " Be", "probability": 0.87451171875}, {"start": 890.78, "end": 891.8, "word": " about", "probability": 0.89990234375}, {"start": 891.8, "end": 892.16, "word": " to.", "probability": 0.95361328125}, {"start": 892.8, "end": 893.16, "word": " The", "probability": 0.89208984375}, {"start": 893.16, "end": 893.52, "word": " taxi", "probability": 0.919921875}, {"start": 893.52, "end": 893.8, "word": " is", "probability": 0.9375}, {"start": 893.8, "end": 894.1, "word": " there", "probability": 0.91064453125}, {"start": 894.1, "end": 894.24, "word": " at", "probability": 0.9306640625}, {"start": 894.24, "end": 894.36, "word": " the", "probability": 0.92724609375}, {"start": 894.36, "end": 894.66, "word": " gate", "probability": 0.93603515625}, {"start": 894.66, "end": 894.88, "word": " and", "probability": 0.8076171875}, {"start": 894.88, "end": 895.08, "word": " we", "probability": 0.96044921875}, {"start": 895.08, "end": 895.32, "word": " are", "probability": 0.93896484375}, {"start": 895.32, "end": 895.68, "word": " about", "probability": 0.90966796875}, {"start": 895.68, "end": 895.94, "word": " to", "probability": 0.96875}, {"start": 895.94, "end": 896.26, "word": " leave.", "probability": 0.96240234375}], "temperature": 1.0}, {"id": 36, "seek": 92728, "start": 898.34, "end": 927.28, "text": " About to. So you have about, verb to be, about, then the infinitive. Okay? It refers to an action or construction that will be fulfilled, an action that will be fulfilled in the near future. We have equivalence of be about to, this is alawashak, as we mentioned.", "tokens": [7769, 281, 13, 407, 291, 362, 466, 11, 9595, 281, 312, 11, 466, 11, 550, 264, 7193, 2187, 13, 1033, 30, 467, 14942, 281, 364, 3069, 420, 6435, 300, 486, 312, 21380, 11, 364, 3069, 300, 486, 312, 21380, 294, 264, 2651, 2027, 13, 492, 362, 9052, 655, 295, 312, 466, 281, 11, 341, 307, 419, 1607, 1299, 514, 11, 382, 321, 2835, 13], "avg_logprob": -0.2745192307692308, "compression_ratio": 1.5562130177514792, "no_speech_prob": 0.0, "words": [{"start": 898.34, "end": 898.86, "word": " About", "probability": 0.4228515625}, {"start": 898.86, "end": 899.22, "word": " to.", "probability": 0.66357421875}, {"start": 899.84, "end": 900.16, "word": " So", "probability": 0.87451171875}, {"start": 900.16, "end": 900.26, "word": " you", "probability": 0.4765625}, {"start": 900.26, "end": 900.44, "word": " have", "probability": 0.94970703125}, {"start": 900.44, "end": 900.86, "word": " about,", "probability": 0.8408203125}, {"start": 901.06, "end": 901.52, "word": " verb", "probability": 0.47998046875}, {"start": 901.52, "end": 901.7, "word": " to", "probability": 0.95849609375}, {"start": 901.7, "end": 901.92, "word": " be,", "probability": 0.9677734375}, {"start": 902.32, "end": 903.02, "word": " about,", "probability": 0.88818359375}, {"start": 903.22, "end": 903.54, "word": " then", "probability": 0.83251953125}, {"start": 903.54, "end": 904.08, "word": " the", "probability": 0.787109375}, {"start": 904.08, "end": 904.86, "word": " infinitive.", "probability": 0.954833984375}, {"start": 906.1, "end": 906.4, "word": " Okay?", "probability": 0.6416015625}, {"start": 907.2, "end": 907.32, "word": " It", "probability": 0.77978515625}, {"start": 907.32, "end": 907.62, "word": " refers", "probability": 0.85693359375}, {"start": 907.62, "end": 907.82, "word": " to", "probability": 0.96923828125}, {"start": 907.82, "end": 908.02, "word": " an", "probability": 0.9521484375}, {"start": 908.02, "end": 908.4, "word": " action", "probability": 0.9423828125}, {"start": 908.4, "end": 908.78, "word": " or", "probability": 0.94189453125}, {"start": 908.78, "end": 909.42, "word": " construction", "probability": 0.9375}, {"start": 909.42, "end": 910.34, "word": " that", "probability": 0.7890625}, {"start": 910.34, "end": 910.52, "word": " will", "probability": 0.8681640625}, {"start": 910.52, "end": 910.72, "word": " be", "probability": 0.94970703125}, {"start": 910.72, "end": 911.02, "word": " fulfilled,", "probability": 0.329833984375}, {"start": 911.1, "end": 911.44, "word": " an", "probability": 0.912109375}, {"start": 911.44, "end": 911.76, "word": " action", "probability": 0.93115234375}, {"start": 911.76, "end": 911.96, "word": " that", "probability": 0.9326171875}, {"start": 911.96, "end": 912.1, "word": " will", "probability": 0.87744140625}, {"start": 912.1, "end": 912.32, "word": " be", "probability": 0.95556640625}, {"start": 912.32, "end": 912.8, "word": " fulfilled", "probability": 0.9521484375}, {"start": 912.8, "end": 913.1, "word": " in", "probability": 0.93896484375}, {"start": 913.1, "end": 913.22, "word": " the", "probability": 0.91650390625}, {"start": 913.22, "end": 913.46, "word": " near", "probability": 0.9248046875}, {"start": 913.46, "end": 913.94, "word": " future.", "probability": 0.9814453125}, {"start": 921.24, "end": 921.88, "word": " We", "probability": 0.9521484375}, {"start": 921.88, "end": 922.1, "word": " have", "probability": 0.9462890625}, {"start": 922.1, "end": 922.82, "word": " equivalence", "probability": 0.873046875}, {"start": 922.82, "end": 923.28, "word": " of", "probability": 0.9716796875}, {"start": 923.28, "end": 923.8, "word": " be", "probability": 0.78955078125}, {"start": 923.8, "end": 924.16, "word": " about", "probability": 0.87646484375}, {"start": 924.16, "end": 924.42, "word": " to,", "probability": 0.96044921875}, {"start": 924.5, "end": 924.64, "word": " this", "probability": 0.9150390625}, {"start": 924.64, "end": 924.82, "word": " is", "probability": 0.95361328125}, {"start": 924.82, "end": 925.48, "word": " alawashak,", "probability": 0.56024169921875}, {"start": 925.58, "end": 926.68, "word": " as", "probability": 0.9580078125}, {"start": 926.68, "end": 926.86, "word": " we", "probability": 0.96533203125}, {"start": 926.86, "end": 927.28, "word": " mentioned.", "probability": 0.83544921875}], "temperature": 1.0}, {"id": 37, "seek": 95670, "start": 928.24, "end": 956.7, "text": " Okay. على وشك أن يأتي أحمد. على وشك أن يأتي. So we have على وشك plus covert derived nominal. Okay. We have B2. 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We are to go to Ahmed's wedding party soon. So we arranged this meeting or we arranged this action. So we are to go to Ahmed's wedding party soon. We are to be ready by nine o'clock. We arranged that, okay?", "tokens": [639, 6435, 3110, 5622, 293, 17620, 13, 492, 366, 281, 352, 281, 39189, 311, 8523, 3595, 2321, 13, 407, 321, 18721, 341, 3440, 420, 321, 18721, 341, 3069, 13, 407, 321, 366, 281, 352, 281, 39189, 311, 8523, 3595, 2321, 13, 492, 366, 281, 312, 1919, 538, 4949, 277, 6, 9023, 13, 492, 18721, 300, 11, 1392, 30], "avg_logprob": -0.1382415254237288, "compression_ratio": 1.7902097902097902, "no_speech_prob": 0.0, "words": [{"start": 959.17, "end": 959.47, "word": " This", "probability": 0.796875}, {"start": 959.47, "end": 959.97, "word": " construction", "probability": 0.93359375}, {"start": 959.97, "end": 960.43, "word": " shows", "probability": 0.89892578125}, {"start": 960.43, "end": 960.85, "word": " command", "probability": 0.77783203125}, {"start": 960.85, "end": 961.69, "word": " and", "probability": 0.9169921875}, {"start": 961.69, "end": 962.41, "word": " arrangement.", "probability": 0.806640625}, {"start": 963.73, "end": 963.87, "word": " We", "probability": 0.68603515625}, {"start": 963.87, "end": 964.07, "word": " are", "probability": 0.91455078125}, {"start": 964.07, "end": 965.21, "word": " to", "probability": 0.619140625}, {"start": 965.21, "end": 965.47, "word": " go", "probability": 0.96826171875}, {"start": 965.47, "end": 965.65, "word": " to", "probability": 0.962890625}, {"start": 965.65, "end": 966.33, "word": " Ahmed's", "probability": 0.869140625}, {"start": 966.33, "end": 966.77, "word": " wedding", "probability": 0.9208984375}, {"start": 966.77, "end": 967.27, "word": " party", "probability": 0.87744140625}, {"start": 967.27, "end": 967.71, "word": " soon.", "probability": 0.94677734375}, {"start": 969.57, "end": 970.07, "word": " So", "probability": 0.9150390625}, {"start": 970.07, "end": 970.23, "word": " we", "probability": 0.72021484375}, {"start": 970.23, "end": 970.81, "word": " arranged", "probability": 0.81103515625}, {"start": 970.81, "end": 971.75, "word": " this", "probability": 0.93896484375}, {"start": 971.75, "end": 973.29, "word": " meeting", "probability": 0.89306640625}, {"start": 973.29, "end": 973.73, "word": " or", "probability": 0.693359375}, {"start": 973.73, "end": 976.51, "word": " we", "probability": 0.8564453125}, {"start": 976.51, "end": 976.91, "word": " arranged", "probability": 0.7626953125}, {"start": 976.91, "end": 977.15, "word": " this", "probability": 0.9404296875}, {"start": 977.15, "end": 977.57, "word": " action.", "probability": 0.94091796875}, {"start": 978.03, "end": 978.39, "word": " So", "probability": 0.91943359375}, {"start": 978.39, "end": 978.73, "word": " we", "probability": 0.83203125}, {"start": 978.73, "end": 978.95, "word": " are", "probability": 0.93603515625}, {"start": 978.95, "end": 979.11, "word": " to", "probability": 0.96728515625}, {"start": 979.11, "end": 979.27, "word": " go", "probability": 0.96875}, {"start": 979.27, "end": 979.43, "word": " to", "probability": 0.96875}, {"start": 979.43, "end": 980.07, "word": " Ahmed's", "probability": 0.961181640625}, {"start": 980.07, "end": 980.41, "word": " wedding", "probability": 0.93505859375}, {"start": 980.41, "end": 980.87, "word": " party", "probability": 0.87890625}, {"start": 980.87, "end": 981.31, "word": " soon.", "probability": 0.955078125}, {"start": 981.85, "end": 982.19, "word": " We", "probability": 0.9541015625}, {"start": 982.19, "end": 982.33, "word": " are", "probability": 0.9013671875}, {"start": 982.33, "end": 982.45, "word": " to", "probability": 0.96875}, {"start": 982.45, "end": 982.63, "word": " be", "probability": 0.95751953125}, {"start": 982.63, "end": 982.93, "word": " ready", "probability": 0.865234375}, {"start": 982.93, "end": 983.27, "word": " by", "probability": 0.96484375}, {"start": 983.27, "end": 983.57, "word": " nine", "probability": 0.7744140625}, {"start": 983.57, "end": 983.79, "word": " o", "probability": 0.98876953125}, {"start": 983.79, "end": 983.97, "word": "'clock.", "probability": 0.96142578125}, {"start": 984.07, "end": 984.17, "word": " We", "probability": 0.9580078125}, {"start": 984.17, "end": 984.55, "word": " arranged", "probability": 0.74755859375}, {"start": 984.55, "end": 984.97, "word": " that,", "probability": 0.93408203125}, {"start": 985.39, "end": 985.67, "word": " okay?", "probability": 0.83056640625}], "temperature": 1.0}, {"id": 39, "seek": 101776, "start": 988.3, "end": 1017.76, "text": " You are to be ready by nine o'clock. You are to be ready by nine o'clock. This is command. Okay. Just in translation, we say, for example, once we say for example, Hind is to marry soon or to get married soon. Hind is to get married soon.", "tokens": [509, 366, 281, 312, 1919, 538, 4949, 277, 6, 9023, 13, 509, 366, 281, 312, 1919, 538, 4949, 277, 6, 9023, 13, 639, 307, 5622, 13, 1033, 13, 1449, 294, 12853, 11, 321, 584, 11, 337, 1365, 11, 1564, 321, 584, 337, 1365, 11, 15307, 307, 281, 9747, 2321, 420, 281, 483, 5259, 2321, 13, 15307, 307, 281, 483, 5259, 2321, 13], "avg_logprob": -0.1540178642386482, "compression_ratio": 1.7445255474452555, "no_speech_prob": 0.0, "words": [{"start": 988.3, "end": 988.58, "word": " You", "probability": 0.685546875}, {"start": 988.58, "end": 988.82, "word": " are", "probability": 0.90283203125}, {"start": 988.82, "end": 988.96, "word": " to", "probability": 0.95947265625}, {"start": 988.96, "end": 989.12, "word": " be", "probability": 0.95654296875}, {"start": 989.12, "end": 989.44, "word": " ready", "probability": 0.85986328125}, {"start": 989.44, "end": 989.7, "word": " by", "probability": 0.9638671875}, {"start": 989.7, "end": 989.98, "word": " nine", "probability": 0.779296875}, {"start": 989.98, "end": 990.32, "word": " o", "probability": 0.97021484375}, {"start": 990.32, "end": 990.4, "word": "'clock.", "probability": 0.94873046875}, {"start": 990.74, "end": 990.9, "word": " You", "probability": 0.84814453125}, {"start": 990.9, "end": 991.2, "word": " are", "probability": 0.9453125}, {"start": 991.2, "end": 991.36, "word": " to", "probability": 0.96875}, {"start": 991.36, "end": 991.5, "word": " be", "probability": 0.95947265625}, {"start": 991.5, "end": 991.76, "word": " ready", "probability": 0.86328125}, {"start": 991.76, "end": 991.96, "word": " by", "probability": 0.962890625}, {"start": 991.96, "end": 992.2, "word": " nine", "probability": 0.9150390625}, {"start": 992.2, "end": 992.44, "word": " o", "probability": 0.974609375}, {"start": 992.44, "end": 992.44, "word": "'clock.", "probability": 0.976318359375}, {"start": 992.58, "end": 992.68, "word": " This", "probability": 0.83740234375}, {"start": 992.68, "end": 993.0, "word": " is", "probability": 0.9521484375}, {"start": 993.0, "end": 993.94, "word": " command.", "probability": 0.69921875}, {"start": 994.82, "end": 995.2, "word": " Okay.", "probability": 0.7060546875}, {"start": 1002.68, "end": 1003.24, "word": " Just", "probability": 0.7666015625}, {"start": 1003.24, "end": 1003.44, "word": " in", "probability": 0.90576171875}, {"start": 1003.44, "end": 1003.8, "word": " translation,", "probability": 0.83935546875}, {"start": 1004.1, "end": 1004.18, "word": " we", "probability": 0.93896484375}, {"start": 1004.18, "end": 1004.38, "word": " say,", "probability": 0.9248046875}, {"start": 1004.52, "end": 1004.56, "word": " for", "probability": 0.9521484375}, {"start": 1004.56, "end": 1005.06, "word": " example,", "probability": 0.97021484375}, {"start": 1007.46, "end": 1007.66, "word": " once", "probability": 0.83154296875}, {"start": 1007.66, "end": 1007.84, "word": " we", "probability": 0.96142578125}, {"start": 1007.84, "end": 1008.14, "word": " say", "probability": 0.95556640625}, {"start": 1008.14, "end": 1008.28, "word": " for", "probability": 0.393798828125}, {"start": 1008.28, "end": 1009.14, "word": " example,", "probability": 0.4267578125}, {"start": 1009.64, "end": 1009.98, "word": " Hind", "probability": 0.40380859375}, {"start": 1009.98, "end": 1011.1, "word": " is", "probability": 0.93408203125}, {"start": 1011.1, "end": 1011.54, "word": " to", "probability": 0.970703125}, {"start": 1011.54, "end": 1011.98, "word": " marry", "probability": 0.90283203125}, {"start": 1011.98, "end": 1012.86, "word": " soon", "probability": 0.94873046875}, {"start": 1012.86, "end": 1013.32, "word": " or", "probability": 0.7578125}, {"start": 1013.32, "end": 1013.44, "word": " to", "probability": 0.9677734375}, {"start": 1013.44, "end": 1013.62, "word": " get", "probability": 0.9443359375}, {"start": 1013.62, "end": 1013.94, "word": " married", "probability": 0.91748046875}, {"start": 1013.94, "end": 1014.36, "word": " soon.", "probability": 0.958984375}, {"start": 1015.96, "end": 1016.52, "word": " Hind", "probability": 0.83740234375}, {"start": 1016.52, "end": 1016.76, "word": " is", "probability": 0.94677734375}, {"start": 1016.76, "end": 1016.92, "word": " to", "probability": 0.9677734375}, {"start": 1016.92, "end": 1017.12, "word": " get", "probability": 0.94189453125}, {"start": 1017.12, "end": 1017.4, "word": " married", "probability": 0.921875}, {"start": 1017.4, "end": 1017.76, "word": " soon.", "probability": 0.9619140625}], "temperature": 1.0}, {"id": 40, "seek": 104396, "start": 1018.24, "end": 1043.96, "text": " Okay. ستتزوج هند قريبا. So we have the near future particle س plus the imperfect indicative form. This means that we don't have equivalent for ب infinitive in Arabic. Going to and ب to are the same. We use س plus the imperfect indicative form of the verb.", "tokens": [1033, 13, 8608, 2655, 2655, 11622, 29245, 8032, 41260, 12174, 16572, 3555, 995, 13, 407, 321, 362, 264, 2651, 2027, 12359, 8608, 1804, 264, 26714, 47513, 1254, 13, 639, 1355, 300, 321, 500, 380, 362, 10344, 337, 4724, 7193, 2187, 294, 19938, 13, 10963, 281, 293, 4724, 281, 366, 264, 912, 13, 492, 764, 8608, 1804, 264, 26714, 47513, 1254, 295, 264, 9595, 13], "avg_logprob": -0.22163461538461537, "compression_ratio": 1.4196891191709844, "no_speech_prob": 0.0, "words": [{"start": 1018.24, "end": 1018.64, "word": " Okay.", "probability": 0.39990234375}, {"start": 1019.68, "end": 1020.42, "word": " ستتزوج", "probability": 0.7017822265625}, {"start": 1020.42, "end": 1020.9, "word": " هند", "probability": 0.6712646484375}, {"start": 1020.9, "end": 1021.8, "word": " قريبا.", "probability": 0.94677734375}, {"start": 1022.68, "end": 1023.42, "word": " So", "probability": 0.77099609375}, {"start": 1023.42, "end": 1023.6, "word": " we", "probability": 0.71142578125}, {"start": 1023.6, "end": 1023.84, "word": " have", "probability": 0.95556640625}, {"start": 1023.84, "end": 1024.0, "word": " the", "probability": 0.89794921875}, {"start": 1024.0, "end": 1024.18, "word": " near", "probability": 0.931640625}, {"start": 1024.18, "end": 1024.56, "word": " future", "probability": 0.88427734375}, {"start": 1024.56, "end": 1025.16, "word": " particle", "probability": 0.8349609375}, {"start": 1025.16, "end": 1025.4, "word": " س", "probability": 0.8408203125}, {"start": 1025.4, "end": 1026.46, "word": " plus", "probability": 0.78125}, {"start": 1026.46, "end": 1027.56, "word": " the", "probability": 0.88671875}, {"start": 1027.56, "end": 1028.24, "word": " imperfect", "probability": 0.9384765625}, {"start": 1028.24, "end": 1028.82, "word": " indicative", "probability": 0.9404296875}, {"start": 1028.82, "end": 1029.44, "word": " form.", "probability": 0.9404296875}, {"start": 1029.84, "end": 1030.06, "word": " This", "probability": 0.9052734375}, {"start": 1030.06, "end": 1030.38, "word": " means", "probability": 0.93310546875}, {"start": 1030.38, "end": 1030.62, "word": " that", "probability": 0.9248046875}, {"start": 1030.62, "end": 1030.74, "word": " we", "probability": 0.962890625}, {"start": 1030.74, "end": 1030.92, "word": " don't", "probability": 0.95849609375}, {"start": 1030.92, "end": 1031.22, "word": " have", "probability": 0.9580078125}, {"start": 1031.22, "end": 1031.84, "word": " equivalent", "probability": 0.84619140625}, {"start": 1031.84, "end": 1032.38, "word": " for", "probability": 0.93408203125}, {"start": 1032.38, "end": 1032.84, "word": " ب", "probability": 0.75537109375}, {"start": 1032.84, "end": 1034.42, "word": " infinitive", "probability": 0.733154296875}, {"start": 1034.42, "end": 1034.68, "word": " in", "probability": 0.93115234375}, {"start": 1034.68, "end": 1035.1, "word": " Arabic.", "probability": 0.93115234375}, {"start": 1037.38, "end": 1037.66, "word": " Going", "probability": 0.160400390625}, {"start": 1037.66, "end": 1038.02, "word": " to", "probability": 0.95849609375}, {"start": 1038.02, "end": 1038.66, "word": " and", "probability": 0.95361328125}, {"start": 1038.66, "end": 1038.92, "word": " ب", "probability": 0.78662109375}, {"start": 1038.92, "end": 1039.2, "word": " to", "probability": 0.330810546875}, {"start": 1039.2, "end": 1039.6, "word": " are", "probability": 0.94482421875}, {"start": 1039.6, "end": 1039.76, "word": " the", "probability": 0.91845703125}, {"start": 1039.76, "end": 1040.02, "word": " same.", "probability": 0.916015625}, {"start": 1040.2, "end": 1040.32, "word": " We", "probability": 0.9384765625}, {"start": 1040.32, "end": 1040.58, "word": " use", "probability": 0.88134765625}, {"start": 1040.58, "end": 1040.86, "word": " س", "probability": 0.974609375}, {"start": 1040.86, "end": 1041.7, "word": " plus", "probability": 0.96240234375}, {"start": 1041.7, "end": 1041.92, "word": " the", "probability": 0.91357421875}, {"start": 1041.92, "end": 1042.36, "word": " imperfect", "probability": 0.9267578125}, {"start": 1042.36, "end": 1042.96, "word": " indicative", "probability": 0.94287109375}, {"start": 1042.96, "end": 1043.4, "word": " form", "probability": 0.9306640625}, {"start": 1043.4, "end": 1043.58, "word": " of", "probability": 0.9638671875}, {"start": 1043.58, "end": 1043.7, "word": " the", "probability": 0.91064453125}, {"start": 1043.7, "end": 1043.96, "word": " verb.", "probability": 0.91796875}], "temperature": 1.0}, {"id": 41, "seek": 107440, "start": 1048.02, "end": 1074.4, "text": " ساحضر حفلة التخرج اليوم مساء I planned for that okay, so we have س plus the imperfect indicative form of the verb Once I translate this into English What do I use? Be to or go to", "tokens": [8608, 39319, 11242, 2288, 11331, 5172, 37977, 16712, 34740, 7435, 45595, 20498, 47524, 16606, 286, 8589, 337, 300, 1392, 11, 370, 321, 362, 8608, 1804, 264, 26714, 47513, 1254, 295, 264, 9595, 3443, 286, 13799, 341, 666, 3669, 708, 360, 286, 764, 30, 879, 281, 420, 352, 281], "avg_logprob": -0.24394132653061223, "compression_ratio": 1.1791907514450868, "no_speech_prob": 0.0, "words": [{"start": 1048.02, "end": 1048.9, "word": " ساحضر", "probability": 0.7130126953125}, {"start": 1048.9, "end": 1049.68, "word": " حفلة", "probability": 0.9777018229166666}, {"start": 1049.68, "end": 1051.14, "word": " التخرج", "probability": 0.9700520833333334}, {"start": 1051.14, "end": 1052.34, "word": " اليوم", "probability": 0.993408203125}, {"start": 1052.34, "end": 1053.32, "word": " مساء", "probability": 0.46722412109375}, {"start": 1053.32, "end": 1054.0, "word": " I", "probability": 0.6728515625}, {"start": 1054.0, "end": 1054.4, "word": " planned", "probability": 0.67041015625}, {"start": 1054.4, "end": 1054.66, "word": " for", "probability": 0.96142578125}, {"start": 1054.66, "end": 1055.06, "word": " that", "probability": 0.9404296875}, {"start": 1055.06, "end": 1055.94, "word": " okay,", "probability": 0.4501953125}, {"start": 1056.28, "end": 1057.58, "word": " so", "probability": 0.95703125}, {"start": 1057.58, "end": 1057.96, "word": " we", "probability": 0.9482421875}, {"start": 1057.96, "end": 1059.94, "word": " have", "probability": 0.9560546875}, {"start": 1059.94, "end": 1060.98, "word": " س", "probability": 0.541015625}, {"start": 1060.98, "end": 1062.12, "word": " plus", "probability": 0.595703125}, {"start": 1062.12, "end": 1062.56, "word": " the", "probability": 0.84912109375}, {"start": 1062.56, "end": 1063.06, "word": " imperfect", "probability": 0.67578125}, {"start": 1063.06, "end": 1063.66, "word": " indicative", "probability": 0.95703125}, {"start": 1063.66, "end": 1064.16, "word": " form", "probability": 0.93603515625}, {"start": 1064.16, "end": 1064.38, "word": " of", "probability": 0.97265625}, {"start": 1064.38, "end": 1064.52, "word": " the", "probability": 0.931640625}, {"start": 1064.52, "end": 1064.88, "word": " verb", "probability": 0.89111328125}, {"start": 1064.88, "end": 1066.62, "word": " Once", "probability": 0.59423828125}, {"start": 1066.62, "end": 1066.78, "word": " I", "probability": 0.98046875}, {"start": 1066.78, "end": 1067.2, "word": " translate", "probability": 0.83251953125}, {"start": 1067.2, "end": 1067.48, "word": " this", "probability": 0.9501953125}, {"start": 1067.48, "end": 1067.84, "word": " into", "probability": 0.86376953125}, {"start": 1067.84, "end": 1068.4, "word": " English", "probability": 0.97607421875}, {"start": 1068.4, "end": 1069.96, "word": " What", "probability": 0.669921875}, {"start": 1069.96, "end": 1070.16, "word": " do", "probability": 0.9677734375}, {"start": 1070.16, "end": 1070.38, "word": " I", "probability": 0.9931640625}, {"start": 1070.38, "end": 1070.82, "word": " use?", "probability": 0.8798828125}, {"start": 1072.36, "end": 1072.52, "word": " Be", "probability": 0.62255859375}, {"start": 1072.52, "end": 1072.82, "word": " to", "probability": 0.7890625}, {"start": 1072.82, "end": 1073.76, "word": " or", "probability": 0.92626953125}, {"start": 1073.76, "end": 1074.04, "word": " go", "probability": 0.509765625}, {"start": 1074.04, "end": 1074.4, "word": " to", "probability": 0.96923828125}], "temperature": 1.0}, {"id": 42, "seek": 110526, "start": 1076.72, "end": 1105.26, "text": " No, no. We have intention here. So if you have intention, this means going to. If there be cause for the action that will happen in future, this is going to. Okay. If there'll be command or arrangement, we use be to. It depends on the meaning of the sentence. So the difference between them is only semantic difference. Okay.", "tokens": [883, 11, 572, 13, 492, 362, 7789, 510, 13, 407, 498, 291, 362, 7789, 11, 341, 1355, 516, 281, 13, 759, 456, 312, 3082, 337, 264, 3069, 300, 486, 1051, 294, 2027, 11, 341, 307, 516, 281, 13, 1033, 13, 759, 456, 603, 312, 5622, 420, 17620, 11, 321, 764, 312, 281, 13, 467, 5946, 322, 264, 3620, 295, 264, 8174, 13, 407, 264, 2649, 1296, 552, 307, 787, 47982, 2649, 13, 1033, 13], "avg_logprob": -0.18947916905085246, "compression_ratio": 1.6979166666666667, "no_speech_prob": 0.0, "words": [{"start": 1076.72, "end": 1076.94, "word": " No,", "probability": 0.6865234375}, {"start": 1077.0, "end": 1077.08, "word": " no.", "probability": 0.71484375}, {"start": 1077.18, "end": 1077.3, "word": " We", "probability": 0.9345703125}, {"start": 1077.3, "end": 1077.6, "word": " have", "probability": 0.94970703125}, {"start": 1077.6, "end": 1078.1, "word": " intention", "probability": 0.94189453125}, {"start": 1078.1, "end": 1078.58, "word": " here.", "probability": 0.85595703125}, 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"probability": 0.94677734375}, {"start": 1097.3, "end": 1097.7, "word": " depends", "probability": 0.90576171875}, {"start": 1097.7, "end": 1098.0, "word": " on", "probability": 0.9521484375}, {"start": 1098.0, "end": 1098.16, "word": " the", "probability": 0.921875}, {"start": 1098.16, "end": 1098.54, "word": " meaning", "probability": 0.8759765625}, {"start": 1098.54, "end": 1098.78, "word": " of", "probability": 0.96728515625}, {"start": 1098.78, "end": 1098.94, "word": " the", "probability": 0.919921875}, {"start": 1098.94, "end": 1099.32, "word": " sentence.", "probability": 0.94482421875}, {"start": 1099.84, "end": 1099.94, "word": " So", "probability": 0.96337890625}, {"start": 1099.94, "end": 1100.1, "word": " the", "probability": 0.85009765625}, {"start": 1100.1, "end": 1100.46, "word": " difference", "probability": 0.875}, {"start": 1100.46, "end": 1100.78, "word": " between", "probability": 0.86962890625}, {"start": 1100.78, "end": 1101.1, "word": " them", "probability": 0.8935546875}, {"start": 1101.1, "end": 1101.54, "word": " is", "probability": 0.9453125}, {"start": 1101.54, "end": 1102.16, "word": " only", "probability": 0.9267578125}, {"start": 1102.16, "end": 1102.7, "word": " semantic", "probability": 0.9501953125}, {"start": 1102.7, "end": 1103.86, "word": " difference.", "probability": 0.8857421875}, {"start": 1104.86, "end": 1105.26, "word": " Okay.", "probability": 0.88818359375}], "temperature": 1.0}, {"id": 43, "seek": 113300, "start": 1107.66, "end": 1133.0, "text": " According to this meaning, you can configure or choose what to use, either going to or B2, or about to, which refers to imminent future. About to, yes. We don't have equivalence for B2 or going to in Arabic, okay?", "tokens": [7328, 281, 341, 3620, 11, 291, 393, 22162, 420, 2826, 437, 281, 764, 11, 2139, 516, 281, 420, 363, 17, 11, 420, 466, 281, 11, 597, 14942, 281, 44339, 2027, 13, 7769, 281, 11, 2086, 13, 492, 500, 380, 362, 9052, 655, 337, 363, 17, 420, 516, 281, 294, 19938, 11, 1392, 30], "avg_logprob": -0.2204861102832688, "compression_ratio": 1.4172185430463575, "no_speech_prob": 0.0, "words": [{"start": 1107.66, "end": 1108.12, "word": " According", "probability": 0.81689453125}, {"start": 1108.12, "end": 1108.34, "word": " to", "probability": 0.96826171875}, {"start": 1108.34, "end": 1108.56, "word": " this", "probability": 0.9384765625}, {"start": 1108.56, "end": 1108.84, "word": " meaning,", "probability": 0.759765625}, {"start": 1109.0, "end": 1109.06, "word": " you", "probability": 0.947265625}, {"start": 1109.06, "end": 1109.32, "word": " can", "probability": 0.9404296875}, {"start": 1109.32, "end": 1109.72, "word": " configure", "probability": 0.80419921875}, {"start": 1109.72, "end": 1110.1, "word": " or", "probability": 0.74072265625}, {"start": 1110.1, "end": 1110.54, "word": " choose", "probability": 0.90625}, {"start": 1110.54, "end": 1111.4, "word": " what", "probability": 0.8671875}, {"start": 1111.4, "end": 1111.6, "word": " to", "probability": 0.8984375}, {"start": 1111.6, "end": 1111.9, "word": " use,", "probability": 0.87939453125}, {"start": 1112.02, "end": 1112.34, "word": " either", "probability": 0.890625}, {"start": 1112.34, "end": 1112.64, "word": " going", "probability": 0.409912109375}, {"start": 1112.64, "end": 1112.92, "word": " to", "probability": 0.91650390625}, {"start": 1112.92, "end": 1113.36, "word": " or", "probability": 0.8955078125}, {"start": 1113.36, "end": 1113.82, "word": " B2,", "probability": 0.8037109375}, {"start": 1114.2, "end": 1114.48, "word": " or", "probability": 0.94287109375}, {"start": 1114.48, "end": 1114.84, "word": " about", "probability": 0.830078125}, {"start": 1114.84, "end": 1115.14, "word": " to,", "probability": 0.87646484375}, {"start": 1115.2, "end": 1115.36, "word": " which", "probability": 0.93701171875}, {"start": 1115.36, "end": 1115.74, "word": " refers", "probability": 0.77978515625}, {"start": 1115.74, "end": 1115.96, "word": " to", "probability": 0.97119140625}, {"start": 1115.96, "end": 1116.32, "word": " imminent", "probability": 0.57958984375}, {"start": 1116.32, "end": 1117.7, "word": " future.", "probability": 0.95263671875}, {"start": 1121.88, "end": 1121.9, "word": " About", "probability": 0.58349609375}, {"start": 1121.9, "end": 1122.94, "word": " to,", "probability": 0.908203125}, {"start": 1123.12, "end": 1123.18, "word": " yes.", "probability": 0.93896484375}, {"start": 1124.02, "end": 1124.1, "word": " We", "probability": 0.60205078125}, {"start": 1124.1, "end": 1127.96, "word": " don't", "probability": 0.957275390625}, {"start": 1127.96, "end": 1128.32, "word": " have", "probability": 0.94970703125}, {"start": 1128.32, "end": 1129.0, "word": " equivalence", "probability": 0.78662109375}, {"start": 1129.0, "end": 1129.24, "word": " for", "probability": 0.90673828125}, {"start": 1129.24, "end": 1129.74, "word": " B2", "probability": 0.978515625}, {"start": 1129.74, "end": 1130.2, "word": " or", "probability": 0.91650390625}, {"start": 1130.2, "end": 1130.58, "word": " going", "probability": 0.92041015625}, {"start": 1130.58, "end": 1130.96, "word": " to", "probability": 0.9697265625}, {"start": 1130.96, "end": 1131.64, "word": " in", "probability": 0.9130859375}, {"start": 1131.64, "end": 1132.0, "word": " Arabic,", "probability": 0.94482421875}, {"start": 1132.22, "end": 1133.0, "word": " okay?", "probability": 0.751953125}], "temperature": 1.0}, {"id": 44, "seek": 115910, "start": 1134.27, "end": 1159.11, "text": " This is future continuous. The same construction of future continuous. However, about to has lexical equivalence. We have على وشك. We don't have, yes. Now we need to see", "tokens": [639, 307, 2027, 10957, 13, 440, 912, 6435, 295, 2027, 10957, 13, 2908, 11, 466, 281, 575, 476, 87, 804, 9052, 655, 13, 492, 362, 15844, 4032, 8592, 4117, 13, 492, 500, 380, 362, 11, 2086, 13, 823, 321, 643, 281, 536], "avg_logprob": -0.26835030040075614, "compression_ratio": 1.2846715328467153, "no_speech_prob": 0.0, "words": [{"start": 1134.27, "end": 1134.57, "word": " This", "probability": 0.6298828125}, {"start": 1134.57, "end": 1134.99, "word": " is", "probability": 0.9384765625}, {"start": 1134.99, "end": 1136.49, "word": " future", "probability": 0.80517578125}, {"start": 1136.49, "end": 1137.13, "word": " continuous.", "probability": 0.80126953125}, {"start": 1139.59, "end": 1139.59, "word": " The", "probability": 0.2420654296875}, {"start": 1139.59, "end": 1140.43, "word": " same", "probability": 0.8857421875}, {"start": 1140.43, "end": 1140.99, "word": " construction", "probability": 0.9501953125}, {"start": 1140.99, "end": 1141.19, "word": " of", "probability": 0.92626953125}, {"start": 1141.19, "end": 1141.47, "word": " future", "probability": 0.9697265625}, {"start": 1141.47, "end": 1142.13, "word": " continuous.", "probability": 0.84033203125}, {"start": 1142.67, "end": 1143.01, "word": " However,", "probability": 0.8486328125}, {"start": 1144.55, "end": 1145.17, "word": " about", "probability": 0.7763671875}, {"start": 1145.17, "end": 1145.53, "word": " to", "probability": 0.80078125}, {"start": 1145.53, "end": 1146.13, "word": " has", "probability": 0.92431640625}, {"start": 1146.13, "end": 1146.77, "word": " lexical", "probability": 0.9425455729166666}, {"start": 1146.77, "end": 1147.45, "word": " equivalence.", "probability": 0.859619140625}, {"start": 1147.59, "end": 1147.63, "word": " We", "probability": 0.84716796875}, {"start": 1147.63, "end": 1148.01, "word": " have", "probability": 0.9365234375}, {"start": 1148.01, "end": 1148.55, "word": " على", "probability": 0.216552734375}, {"start": 1148.55, "end": 1149.09, "word": " وشك.", "probability": 0.9326171875}, {"start": 1151.19, "end": 1151.79, "word": " We", "probability": 0.1767578125}, {"start": 1151.79, "end": 1153.89, "word": " don't", "probability": 0.977294921875}, {"start": 1153.89, "end": 1154.13, "word": " have,", "probability": 0.953125}, {"start": 1154.15, "end": 1154.43, "word": " yes.", "probability": 0.939453125}, {"start": 1157.31, "end": 1158.39, "word": " Now", "probability": 0.96484375}, {"start": 1158.39, "end": 1158.53, "word": " we", "probability": 0.8095703125}, {"start": 1158.53, "end": 1158.69, "word": " need", "probability": 0.93115234375}, {"start": 1158.69, "end": 1158.83, "word": " to", "probability": 0.97216796875}, {"start": 1158.83, "end": 1159.11, "word": " see", "probability": 0.8505859375}], "temperature": 1.0}, {"id": 45, "seek": 118936, "start": 1160.49, "end": 1189.37, "text": " Future in the past. Planned actions which were not fulfilled in the past. I arranged to see you yesterday, but I could not. How could I express that? I was to travel yesterday, but I didn't. Okay?", "tokens": [20805, 294, 264, 1791, 13, 2149, 5943, 5909, 597, 645, 406, 21380, 294, 264, 1791, 13, 286, 18721, 281, 536, 291, 5186, 11, 457, 286, 727, 406, 13, 1012, 727, 286, 5109, 300, 30, 286, 390, 281, 3147, 5186, 11, 457, 286, 994, 380, 13, 1033, 30], "avg_logprob": -0.1686197898040215, "compression_ratio": 1.4275362318840579, "no_speech_prob": 0.0, "words": [{"start": 1160.49, "end": 1161.09, "word": " Future", "probability": 0.533203125}, {"start": 1161.09, "end": 1161.43, "word": " in", "probability": 0.87451171875}, {"start": 1161.43, "end": 1161.57, "word": " the", "probability": 0.91259765625}, {"start": 1161.57, "end": 1162.01, "word": " past.", "probability": 0.80029296875}, {"start": 1162.77, "end": 1163.31, "word": " Planned", "probability": 0.7403564453125}, {"start": 1163.31, "end": 1164.01, "word": " actions", "probability": 0.853515625}, {"start": 1164.01, "end": 1165.03, "word": " which", "probability": 0.5712890625}, {"start": 1165.03, "end": 1167.47, "word": " were", "probability": 0.71533203125}, {"start": 1167.47, "end": 1167.75, "word": " not", "probability": 0.94677734375}, {"start": 1167.75, "end": 1169.55, "word": " fulfilled", "probability": 0.9443359375}, {"start": 1169.55, "end": 1170.11, "word": " in", "probability": 0.939453125}, {"start": 1170.11, "end": 1171.69, "word": " the", "probability": 0.91455078125}, {"start": 1171.69, "end": 1172.15, "word": " past.", "probability": 0.89208984375}, {"start": 1172.51, "end": 1173.31, "word": " I", "probability": 0.91064453125}, {"start": 1173.31, "end": 1173.87, "word": " arranged", "probability": 0.90380859375}, {"start": 1173.87, "end": 1174.11, "word": " to", "probability": 0.97216796875}, {"start": 1174.11, "end": 1174.33, "word": " see", "probability": 0.916015625}, {"start": 1174.33, "end": 1174.69, "word": " you", "probability": 0.9658203125}, {"start": 1174.69, "end": 1175.67, "word": " yesterday,", "probability": 0.8427734375}, {"start": 1176.17, "end": 1176.45, "word": " but", "probability": 0.9267578125}, {"start": 1176.45, "end": 1176.61, "word": " I", "probability": 0.9912109375}, {"start": 1176.61, "end": 1176.81, "word": " could", "probability": 0.86376953125}, {"start": 1176.81, "end": 1177.09, "word": " not.", "probability": 0.95703125}, {"start": 1178.35, "end": 1178.83, "word": " How", "probability": 0.9462890625}, {"start": 1178.83, "end": 1179.05, "word": " could", "probability": 0.82763671875}, {"start": 1179.05, "end": 1179.21, "word": " I", "probability": 0.994140625}, {"start": 1179.21, "end": 1179.51, "word": " express", "probability": 0.927734375}, {"start": 1179.51, "end": 1180.01, "word": " that?", "probability": 0.9345703125}, {"start": 1182.41, "end": 1183.41, "word": " I", "probability": 0.9873046875}, {"start": 1183.41, "end": 1183.71, "word": " was", "probability": 0.919921875}, {"start": 1183.71, "end": 1183.87, "word": " to", "probability": 0.9150390625}, {"start": 1183.87, "end": 1184.23, "word": " travel", "probability": 0.86376953125}, {"start": 1184.23, "end": 1184.91, "word": " yesterday,", "probability": 0.8310546875}, {"start": 1185.41, "end": 1186.17, "word": " but", "probability": 0.923828125}, {"start": 1186.17, "end": 1186.51, "word": " I", "probability": 0.99609375}, {"start": 1186.51, "end": 1187.39, "word": " didn't.", "probability": 0.924072265625}, {"start": 1188.85, "end": 1189.37, "word": " Okay?", "probability": 0.6748046875}], "temperature": 1.0}, {"id": 46, "seek": 122058, "start": 1192.2, "end": 1220.58, "text": " I arranged to come to the university for teaching you another lecture yesterday, but I could not come. So how could I express this in future constructions? Okay, we have the same constructions. For example, he was later to regret his bad behavior. Was to, meaning be to. But instead of using", "tokens": [286, 18721, 281, 808, 281, 264, 5454, 337, 4571, 291, 1071, 7991, 5186, 11, 457, 286, 727, 406, 808, 13, 407, 577, 727, 286, 5109, 341, 294, 2027, 7690, 626, 30, 1033, 11, 321, 362, 264, 912, 7690, 626, 13, 1171, 1365, 11, 415, 390, 1780, 281, 10879, 702, 1578, 5223, 13, 3027, 281, 11, 3620, 312, 281, 13, 583, 2602, 295, 1228], "avg_logprob": -0.16650390182621777, "compression_ratio": 1.482233502538071, "no_speech_prob": 0.0, "words": [{"start": 1192.2, "end": 1192.46, "word": " I", "probability": 0.81591796875}, {"start": 1192.46, "end": 1192.88, "word": " arranged", "probability": 0.83935546875}, {"start": 1192.88, "end": 1193.1, "word": " to", "probability": 0.96435546875}, {"start": 1193.1, "end": 1193.3, "word": " come", "probability": 0.8720703125}, {"start": 1193.3, "end": 1193.42, "word": " to", "probability": 0.96728515625}, {"start": 1193.42, "end": 1193.56, "word": " the", "probability": 0.89111328125}, {"start": 1193.56, "end": 1194.08, "word": " university", "probability": 0.7939453125}, {"start": 1194.08, "end": 1194.52, "word": " for", "probability": 0.88232421875}, {"start": 1194.52, "end": 1194.94, "word": " teaching", "probability": 0.9013671875}, {"start": 1194.94, "end": 1195.36, "word": " you", "probability": 0.9501953125}, {"start": 1195.36, "end": 1197.16, "word": " another", "probability": 0.865234375}, {"start": 1197.16, "end": 1197.62, "word": " lecture", "probability": 0.9501953125}, {"start": 1197.62, "end": 1198.18, "word": " yesterday,", "probability": 0.83056640625}, {"start": 1198.8, "end": 1199.28, "word": " but", "probability": 0.91357421875}, {"start": 1199.28, "end": 1199.4, "word": " I", "probability": 0.9716796875}, {"start": 1199.4, "end": 1199.54, "word": " could", "probability": 0.89599609375}, {"start": 1199.54, "end": 1199.7, "word": " not", "probability": 0.95703125}, {"start": 1199.7, "end": 1200.02, "word": " come.", "probability": 0.8671875}, {"start": 1200.76, "end": 1200.98, "word": " So", "probability": 0.89794921875}, {"start": 1200.98, "end": 1201.16, "word": " how", "probability": 0.74365234375}, {"start": 1201.16, "end": 1201.4, "word": " could", "probability": 0.85888671875}, {"start": 1201.4, "end": 1201.54, "word": " I", "probability": 0.9931640625}, {"start": 1201.54, "end": 1201.96, "word": " express", "probability": 0.90283203125}, {"start": 1201.96, "end": 1202.38, "word": " this", "probability": 0.94140625}, {"start": 1202.38, "end": 1203.88, "word": " in", "probability": 0.91064453125}, {"start": 1203.88, "end": 1204.6, "word": " future", "probability": 0.9716796875}, {"start": 1204.6, "end": 1205.5, "word": " constructions?", "probability": 0.919677734375}, {"start": 1206.04, "end": 1206.46, "word": " Okay,", "probability": 0.68798828125}, {"start": 1206.68, "end": 1207.0, "word": " we", "probability": 0.95654296875}, {"start": 1207.0, "end": 1207.16, "word": " have", "probability": 0.9462890625}, {"start": 1207.16, "end": 1207.32, "word": " the", "probability": 0.92041015625}, {"start": 1207.32, "end": 1207.58, "word": " same", "probability": 0.89697265625}, {"start": 1207.58, "end": 1208.48, "word": " constructions.", "probability": 0.940673828125}, {"start": 1209.68, "end": 1209.96, "word": " For", "probability": 0.9541015625}, {"start": 1209.96, "end": 1210.4, "word": " example,", "probability": 0.97021484375}, {"start": 1211.86, "end": 1211.98, "word": " he", "probability": 0.857421875}, {"start": 1211.98, "end": 1212.22, "word": " was", "probability": 0.8623046875}, {"start": 1212.22, "end": 1212.5, "word": " later", "probability": 0.93115234375}, {"start": 1212.5, "end": 1212.7, "word": " to", "probability": 0.970703125}, {"start": 1212.7, "end": 1213.04, "word": " regret", "probability": 0.86181640625}, {"start": 1213.04, "end": 1213.36, "word": " his", "probability": 0.96435546875}, {"start": 1213.36, "end": 1213.76, "word": " bad", "probability": 0.94091796875}, {"start": 1213.76, "end": 1214.34, "word": " behavior.", "probability": 0.8056640625}, {"start": 1215.72, "end": 1215.92, "word": " Was", "probability": 0.79443359375}, {"start": 1215.92, "end": 1216.16, "word": " to,", "probability": 0.90869140625}, {"start": 1216.26, "end": 1216.46, "word": " meaning", "probability": 0.5009765625}, {"start": 1216.46, "end": 1216.74, "word": " be", "probability": 0.289794921875}, {"start": 1216.74, "end": 1217.06, "word": " to.", "probability": 0.947265625}, {"start": 1219.26, "end": 1219.78, "word": " But", "probability": 0.86474609375}, {"start": 1219.78, "end": 1220.04, "word": " instead", "probability": 0.8671875}, {"start": 1220.04, "end": 1220.18, "word": " of", "probability": 0.9658203125}, {"start": 1220.18, "end": 1220.58, "word": " using", "probability": 0.9384765625}], "temperature": 1.0}, {"id": 47, "seek": 124867, "start": 1222.35, "end": 1248.67, "text": " SMR we use was, it refers to the past. I made the needed maintenance to my car so that it would pass the safety inspection. He had it because he knew that he was going to be late. I was about to miss the train. I was meeting him at the Islamic University of Gaza the next day. Now we need to translate these into Arabic.", "tokens": [13115, 49, 321, 764, 390, 11, 309, 14942, 281, 264, 1791, 13, 286, 1027, 264, 2978, 11258, 281, 452, 1032, 370, 300, 309, 576, 1320, 264, 4514, 22085, 13, 634, 632, 309, 570, 415, 2586, 300, 415, 390, 516, 281, 312, 3469, 13, 286, 390, 466, 281, 1713, 264, 3847, 13, 286, 390, 3440, 796, 412, 264, 17970, 3535, 295, 37800, 264, 958, 786, 13, 823, 321, 643, 281, 13799, 613, 666, 19938, 13], "avg_logprob": -0.1503125, "compression_ratio": 1.5658536585365854, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1222.3500000000001, "end": 1222.95, "word": " SMR", "probability": 0.7353515625}, {"start": 1222.95, "end": 1223.17, "word": " we", "probability": 0.45947265625}, {"start": 1223.17, "end": 1223.57, "word": " use", "probability": 0.86572265625}, {"start": 1223.57, "end": 1224.57, "word": " was,", "probability": 0.2095947265625}, {"start": 1224.71, "end": 1224.83, "word": " it", "probability": 0.7421875}, {"start": 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It's called paraphrasing in translation. He hurried because he knew that he was going to be late. Yes. He hurried.", "tokens": [1033, 11, 370, 291, 393, 36992, 1703, 651, 341, 8174, 412, 264, 917, 13, 467, 311, 1219, 36992, 1703, 3349, 294, 12853, 13, 634, 2756, 2428, 570, 415, 2586, 300, 415, 390, 516, 281, 312, 3469, 13, 1079, 13, 634, 2756, 2428, 13], "avg_logprob": -0.19371448999101465, "compression_ratio": 1.3852459016393444, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1340.31, "end": 1340.55, "word": " Okay,", "probability": 0.640625}, {"start": 1340.89, "end": 1341.09, "word": " so", "probability": 0.9482421875}, {"start": 1341.09, "end": 1341.25, "word": " you", "probability": 0.953125}, {"start": 1341.25, "end": 1341.45, "word": " can", "probability": 0.951171875}, {"start": 1341.45, "end": 1342.11, "word": " paraphrase", "probability": 0.9386393229166666}, {"start": 1342.11, "end": 1342.53, "word": " this", "probability": 0.9521484375}, {"start": 1342.53, "end": 1343.61, "word": " sentence", "probability": 0.876953125}, {"start": 1343.61, "end": 1343.93, "word": " at", "probability": 0.603515625}, {"start": 1343.93, "end": 1344.05, "word": " the", "probability": 0.923828125}, {"start": 1344.05, "end": 1344.37, "word": " end.", "probability": 0.89794921875}, {"start": 1346.45, "end": 1347.17, "word": " It's", "probability": 0.3897705078125}, {"start": 1347.17, "end": 1350.33, "word": " called", "probability": 0.845703125}, {"start": 1350.33, "end": 1351.11, "word": " paraphrasing", "probability": 0.9488932291666666}, {"start": 1351.11, "end": 1351.33, "word": " in", "probability": 0.8828125}, {"start": 1351.33, "end": 1351.89, "word": " translation.", "probability": 0.869140625}, {"start": 1354.01, "end": 1354.07, "word": " He", "probability": 0.74462890625}, {"start": 1354.07, "end": 1354.41, "word": " hurried", "probability": 0.7340087890625}, {"start": 1354.41, "end": 1354.79, "word": " because", "probability": 0.87255859375}, {"start": 1354.79, "end": 1355.11, "word": " he", "probability": 0.96484375}, {"start": 1355.11, "end": 1355.39, "word": " knew", "probability": 0.76611328125}, {"start": 1355.39, "end": 1355.85, "word": " that", "probability": 0.90673828125}, {"start": 1355.85, "end": 1356.07, "word": " he", "probability": 0.94140625}, {"start": 1356.07, "end": 1356.49, "word": " was", "probability": 0.947265625}, {"start": 1356.49, "end": 1356.79, "word": " going", "probability": 0.939453125}, {"start": 1356.79, "end": 1356.95, "word": " to", "probability": 0.970703125}, {"start": 1356.95, "end": 1357.15, "word": " be", "probability": 0.95556640625}, {"start": 1357.15, "end": 1357.49, "word": " late.", "probability": 0.93359375}, {"start": 1361.57, "end": 1362.29, "word": " Yes.", "probability": 0.78271484375}, {"start": 1364.93, "end": 1365.65, "word": " He", "probability": 0.90234375}, {"start": 1365.65, "end": 1366.03, "word": " hurried.", "probability": 0.972900390625}], "temperature": 1.0}, {"id": 52, "seek": 139547, "start": 1376.85, "end": 1395.47, "text": " I was about to miss the train. Yes? Did I miss it? No. Okay. I was meeting him at the Islamic University of Gaza the next day.", "tokens": [286, 390, 466, 281, 1713, 264, 3847, 13, 1079, 30, 2589, 286, 1713, 309, 30, 883, 13, 1033, 13, 286, 390, 3440, 796, 412, 264, 17970, 3535, 295, 37800, 264, 958, 786, 13], "avg_logprob": -0.24701285625205321, "compression_ratio": 1.1759259259259258, "no_speech_prob": 0.0, "words": [{"start": 1376.85, "end": 1377.49, "word": " I", "probability": 0.0823974609375}, {"start": 1377.49, "end": 1378.13, "word": " was", "probability": 0.77880859375}, {"start": 1378.13, "end": 1378.37, "word": " about", "probability": 0.90673828125}, {"start": 1378.37, "end": 1378.69, "word": " to", "probability": 0.9736328125}, {"start": 1378.69, "end": 1378.89, "word": " miss", "probability": 0.91845703125}, {"start": 1378.89, "end": 1379.07, "word": " the", "probability": 0.91357421875}, {"start": 1379.07, "end": 1379.39, "word": " train.", "probability": 0.93310546875}, {"start": 1381.21, "end": 1381.39, "word": " Yes?", "probability": 0.470703125}, {"start": 1383.79, "end": 1383.79, "word": " Did", "probability": 0.51806640625}, {"start": 1383.79, "end": 1384.11, "word": " I", "probability": 0.99072265625}, {"start": 1384.11, "end": 1384.33, "word": " miss", "probability": 0.90478515625}, {"start": 1384.33, "end": 1386.73, "word": " it?", "probability": 0.94873046875}, {"start": 1387.17, "end": 1387.81, "word": " No.", "probability": 0.9228515625}, {"start": 1388.99, "end": 1389.29, "word": " Okay.", "probability": 0.611328125}, {"start": 1391.23, "end": 1391.87, "word": " I", "probability": 0.99169921875}, {"start": 1391.87, "end": 1392.23, "word": " was", "probability": 0.9501953125}, {"start": 1392.23, "end": 1392.57, "word": " meeting", "probability": 0.91748046875}, {"start": 1392.57, "end": 1392.85, "word": " him", "probability": 0.9287109375}, {"start": 1392.85, "end": 1393.01, "word": " at", "probability": 0.93115234375}, {"start": 1393.01, "end": 1393.13, "word": " the", "probability": 0.89306640625}, {"start": 1393.13, "end": 1393.41, "word": " Islamic", "probability": 0.86669921875}, {"start": 1393.41, "end": 1394.07, "word": " University", "probability": 0.59814453125}, {"start": 1394.07, "end": 1394.35, "word": " of", "probability": 0.96044921875}, {"start": 1394.35, "end": 1394.65, "word": " Gaza", "probability": 0.8974609375}, {"start": 1394.65, "end": 1394.87, "word": " the", "probability": 0.84521484375}, {"start": 1394.87, "end": 1395.11, "word": " next", "probability": 0.94189453125}, {"start": 1395.11, "end": 1395.47, "word": " day.", "probability": 0.9501953125}], "temperature": 1.0}, {"id": 53, "seek": 142412, "start": 1397.12, "end": 1424.12, "text": " Yes. Okay. Okay. But that did not happen. So we speak about actions that were to happen, but not happened. Okay. So we use the same constructions, but in the past.", "tokens": [1079, 13, 1033, 13, 1033, 13, 583, 300, 630, 406, 1051, 13, 407, 321, 1710, 466, 5909, 300, 645, 281, 1051, 11, 457, 406, 2011, 13, 1033, 13, 407, 321, 764, 264, 912, 7690, 626, 11, 457, 294, 264, 1791, 13], "avg_logprob": -0.2016369015687988, "compression_ratio": 1.4513274336283186, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 1397.1200000000001, "end": 1397.96, "word": " Yes.", "probability": 0.5986328125}, {"start": 1401.8, "end": 1402.32, "word": " Okay.", "probability": 0.122802734375}, {"start": 1405.4, "end": 1406.24, "word": " Okay.", "probability": 0.1522216796875}, {"start": 1409.62, "end": 1409.62, "word": " But", "probability": 0.307861328125}, {"start": 1409.62, "end": 1409.92, "word": " that", "probability": 0.93701171875}, {"start": 1409.92, "end": 1410.5, "word": " did", "probability": 0.7578125}, {"start": 1410.5, "end": 1410.72, "word": " not", "probability": 0.9560546875}, {"start": 1410.72, "end": 1411.04, "word": " happen.", "probability": 0.8837890625}, {"start": 1412.06, "end": 1412.9, "word": " So", "probability": 0.93505859375}, {"start": 1412.9, "end": 1413.1, "word": " we", "probability": 0.85595703125}, {"start": 1413.1, "end": 1413.42, "word": " speak", "probability": 0.982421875}, {"start": 1413.42, "end": 1413.92, "word": " about", "probability": 0.91357421875}, {"start": 1413.92, "end": 1414.64, "word": " actions", "probability": 0.9169921875}, {"start": 1414.64, "end": 1415.66, "word": " that", "probability": 0.91357421875}, {"start": 1415.66, "end": 1416.08, "word": " were", "probability": 0.8525390625}, {"start": 1416.08, "end": 1416.3, "word": " to", "probability": 0.9697265625}, {"start": 1416.3, "end": 1416.74, "word": " happen,", "probability": 0.91552734375}, {"start": 1417.5, "end": 1417.78, "word": " but", "probability": 0.92724609375}, {"start": 1417.78, "end": 1418.98, "word": " not", "probability": 0.865234375}, {"start": 1418.98, "end": 1419.42, "word": " happened.", "probability": 0.64599609375}, {"start": 1419.9, "end": 1420.22, "word": " Okay.", "probability": 0.82080078125}, {"start": 1420.7, "end": 1421.02, "word": " So", "probability": 0.95703125}, {"start": 1421.02, "end": 1421.22, "word": " we", "probability": 0.923828125}, {"start": 1421.22, "end": 1421.5, "word": " use", "probability": 0.8759765625}, {"start": 1421.5, "end": 1421.66, "word": " the", "probability": 0.916015625}, {"start": 1421.66, "end": 1421.88, "word": " same", "probability": 0.8818359375}, {"start": 1421.88, "end": 1422.76, "word": " constructions,", "probability": 0.939453125}, {"start": 1423.22, "end": 1423.4, "word": " but", "probability": 0.93115234375}, {"start": 1423.4, "end": 1423.6, "word": " in", "probability": 0.9482421875}, {"start": 1423.6, "end": 1423.76, "word": " the", "probability": 0.91748046875}, {"start": 1423.76, "end": 1424.12, "word": " past.", "probability": 0.91552734375}], "temperature": 1.0}, {"id": 54, "seek": 145532, "start": 1427.74, "end": 1455.32, "text": " We have them, we have their equivalence in Arabic, but lexically. كان عليا أن أقابله. Okay? So we don't have equivalence for B2 and Gong2 as we mentioned, but we have على وشك. Okay? And كان عليا أن أقابله. 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"end": 1483.2, "text": " He hurried because he knew that he was going to be late. This means that he was not late. He reached his", "tokens": [634, 2756, 2428, 570, 415, 2586, 300, 415, 390, 516, 281, 312, 3469, 13, 639, 1355, 300, 415, 390, 406, 3469, 13, 634, 6488, 702], "avg_logprob": -0.2910156376086749, "compression_ratio": 1.2352941176470589, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 1469.78, "end": 1470.46, "word": " He", "probability": 0.181884765625}, {"start": 1470.46, "end": 1471.14, "word": " hurried", "probability": 0.645751953125}, {"start": 1471.14, "end": 1474.26, "word": " because", "probability": 0.66015625}, {"start": 1474.26, "end": 1474.64, "word": " he", "probability": 0.95849609375}, {"start": 1474.64, "end": 1474.82, "word": " knew", "probability": 0.70458984375}, {"start": 1474.82, "end": 1475.08, "word": " that", "probability": 0.73828125}, {"start": 1475.08, "end": 1475.22, "word": " he", "probability": 0.93017578125}, {"start": 1475.22, "end": 1475.46, "word": " was", "probability": 0.89404296875}, {"start": 1475.46, "end": 1475.84, "word": " going", 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0.88818359375}, {"start": 1482.62, "end": 1483.2, "word": " his", "probability": 0.94970703125}], "temperature": 1.0}, {"id": 56, "seek": 149937, "start": 1484.63, "end": 1499.37, "text": " Yes, he reached his place or his He reached his work or whatever just on time Okay, he reached his destination on time Fine", "tokens": [1079, 11, 415, 6488, 702, 1081, 420, 702, 634, 6488, 702, 589, 420, 2035, 445, 322, 565, 1033, 11, 415, 6488, 702, 12236, 322, 565, 12024], "avg_logprob": -0.26996528881567494, "compression_ratio": 1.3777777777777778, "no_speech_prob": 0.0, "words": [{"start": 1484.63, "end": 1485.39, "word": " Yes,", "probability": 0.2071533203125}, {"start": 1486.37, "end": 1486.49, "word": " he", "probability": 0.88623046875}, {"start": 1486.49, "end": 1487.11, "word": " reached", "probability": 0.82275390625}, {"start": 1487.11, "end": 1487.49, "word": " his", "probability": 0.96435546875}, {"start": 1487.49, "end": 1487.91, "word": " place", "probability": 0.84326171875}, 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attend", "probability": 0.8642578125}, {"start": 1578.01, "end": 1578.31, "word": " if", "probability": 0.96875}, {"start": 1578.31, "end": 1579.47, "word": " agreed", "probability": 0.57666015625}, {"start": 1579.47, "end": 1579.93, "word": " you", "probability": 0.91796875}, {"start": 1579.93, "end": 1580.29, "word": " or", "probability": 0.96923828125}, {"start": 1580.29, "end": 1580.59, "word": " not", "probability": 0.94287109375}, {"start": 1580.59, "end": 1581.03, "word": " agreed", "probability": 0.90625}, {"start": 1581.03, "end": 1581.29, "word": " you", "probability": 0.919921875}, {"start": 1581.29, "end": 1581.47, "word": " and", "probability": 0.396728515625}, {"start": 1581.47, "end": 1581.63, "word": " it", "probability": 0.96533203125}, {"start": 1581.63, "end": 1581.89, "word": " was", "probability": 0.95654296875}, {"start": 1581.89, "end": 1582.21, "word": " for", "probability": 0.95947265625}, {"start": 1582.21, "end": 1582.49, "word": " zayd", "probability": 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This is called transliteration. Once you translate a sentence from Arabic to English, you have to write the sentence, the original sentence in Arabic using English alphabet. Then you write transliteration word by word. Then you translate the sentence. Okay.", "tokens": [1033, 13, 639, 307, 1219, 5105, 1681, 399, 13, 3443, 291, 13799, 257, 8174, 490, 19938, 281, 3669, 11, 291, 362, 281, 2464, 264, 8174, 11, 264, 3380, 8174, 294, 19938, 1228, 3669, 23339, 13, 1396, 291, 2464, 5105, 1681, 399, 1349, 538, 1349, 13, 1396, 291, 13799, 264, 8174, 13, 1033, 13], "avg_logprob": -0.12637442460766546, "compression_ratio": 1.7254901960784315, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1585.49, "end": 1585.87, "word": " Okay.", "probability": 0.5888671875}, {"start": 1586.67, "end": 1587.15, "word": " This", "probability": 0.8779296875}, {"start": 1587.15, "end": 1587.29, "word": " is", "probability": 0.94921875}, {"start": 1587.29, "end": 1587.57, "word": " called", "probability": 0.8876953125}, {"start": 1587.57, "end": 1588.57, "word": " transliteration.", "probability": 0.9615885416666666}, {"start": 1589.23, "end": 1589.95, "word": " Once", "probability": 0.9248046875}, {"start": 1589.95, "end": 1590.13, "word": " you", "probability": 0.9658203125}, {"start": 1590.13, "end": 1590.57, "word": " translate", "probability": 0.806640625}, {"start": 1590.57, "end": 1590.79, "word": " a", "probability": 0.97998046875}, {"start": 1590.79, "end": 1591.27, "word": " sentence", "probability": 0.9443359375}, {"start": 1591.27, "end": 1592.21, "word": " from", "probability": 0.859375}, {"start": 1592.21, "end": 1593.05, "word": " Arabic", "probability": 0.90576171875}, {"start": 1593.05, "end": 1593.29, "word": " to", "probability": 0.9716796875}, {"start": 1593.29, "end": 1593.57, "word": " English,", "probability": 0.97802734375}, {"start": 1593.59, "end": 1593.75, "word": " you", "probability": 0.95751953125}, {"start": 1593.75, "end": 1594.01, "word": " have", "probability": 0.9453125}, {"start": 1594.01, "end": 1594.47, "word": " to", "probability": 0.962890625}, {"start": 1594.47, "end": 1594.75, "word": " write", "probability": 0.90869140625}, {"start": 1594.75, "end": 1594.95, "word": " the", "probability": 0.9140625}, {"start": 1594.95, "end": 1595.31, "word": " sentence,", "probability": 0.83154296875}, {"start": 1595.45, "end": 1595.49, "word": " the", "probability": 0.916015625}, {"start": 1595.49, "end": 1595.83, "word": " original", "probability": 0.94287109375}, {"start": 1595.83, "end": 1596.35, "word": " sentence", "probability": 0.94873046875}, {"start": 1596.35, "end": 1596.53, "word": " in", "probability": 0.86669921875}, {"start": 1596.53, "end": 1596.83, "word": " Arabic", "probability": 0.90869140625}, {"start": 1596.83, "end": 1597.27, "word": " using", "probability": 0.8046875}, {"start": 1597.27, "end": 1597.87, "word": " English", "probability": 0.95751953125}, {"start": 1597.87, "end": 1598.91, "word": " alphabet.", "probability": 0.91064453125}, {"start": 1599.49, "end": 1599.81, "word": " Then", "probability": 0.87060546875}, {"start": 1599.81, "end": 1599.95, "word": " you", "probability": 0.93701171875}, {"start": 1599.95, "end": 1600.35, "word": " write", "probability": 0.873046875}, {"start": 1600.35, "end": 1601.35, "word": " transliteration", "probability": 0.96923828125}, {"start": 1601.35, "end": 1601.85, "word": " word", "probability": 0.666015625}, {"start": 1601.85, "end": 1602.09, "word": " by", "probability": 0.91259765625}, {"start": 1602.09, "end": 1602.53, "word": " word.", "probability": 0.94140625}, {"start": 1602.87, "end": 1603.19, "word": " Then", "probability": 0.86865234375}, {"start": 1603.19, "end": 1603.35, "word": " you", "probability": 0.95654296875}, {"start": 1603.35, "end": 1603.77, "word": " translate", "probability": 0.81201171875}, {"start": 1603.77, "end": 1603.99, "word": " the", "probability": 0.9130859375}, {"start": 1603.99, "end": 1604.45, "word": " sentence.", "probability": 0.947265625}, {"start": 1608.37, "end": 1609.09, "word": " Okay.", "probability": 0.8701171875}], "temperature": 1.0}, {"id": 60, "seek": 164102, "start": 1619.9, "end": 1641.02, "text": " What do you understand from this? Does the action happen? No. What refers to the past?", "tokens": [708, 360, 291, 1223, 490, 341, 30, 4402, 264, 3069, 1051, 30, 883, 13, 708, 14942, 281, 264, 1791, 30], "avg_logprob": -0.2609747080575852, "compression_ratio": 1.0740740740740742, "no_speech_prob": 0.0, "words": [{"start": 1619.8999999999999, "end": 1620.78, "word": " What", "probability": 0.2188720703125}, {"start": 1620.78, "end": 1621.66, "word": " do", "probability": 0.88525390625}, {"start": 1621.66, "end": 1621.74, "word": " you", "probability": 0.97021484375}, {"start": 1621.74, "end": 1622.16, "word": " understand", "probability": 0.81005859375}, {"start": 1622.16, "end": 1622.46, "word": " from", "probability": 0.88818359375}, {"start": 1622.46, "end": 1622.8, "word": " this?", "probability": 0.9462890625}, {"start": 1623.54, "end": 1624.34, "word": " Does", "probability": 0.79345703125}, {"start": 1624.34, "end": 1624.48, "word": " the", "probability": 0.87353515625}, {"start": 1624.48, "end": 1624.86, "word": " action", "probability": 0.93994140625}, {"start": 1624.86, "end": 1625.3, "word": " happen?", "probability": 0.8994140625}, {"start": 1626.4, "end": 1626.4, "word": " No.", "probability": 0.689453125}, {"start": 1637.86, "end": 1638.54, "word": " What", "probability": 0.1610107421875}, {"start": 1638.54, "end": 1640.24, "word": " refers", "probability": 0.79345703125}, {"start": 1640.24, "end": 1640.42, "word": " to", "probability": 0.97216796875}, {"start": 1640.42, "end": 1640.56, "word": " the", "probability": 0.92236328125}, {"start": 1640.56, "end": 1641.02, "word": " past?", "probability": 0.8779296875}], "temperature": 1.0}, {"id": 61, "seek": 167096, "start": 1652.7, "end": 1670.96, "text": " It refers to an action that was to happen in the past. My father or dad recommended me to do good all over my life.", "tokens": [467, 14942, 281, 364, 3069, 300, 390, 281, 1051, 294, 264, 1791, 13, 1222, 3086, 420, 3546, 9628, 385, 281, 360, 665, 439, 670, 452, 993, 13], "avg_logprob": -0.20786830091050693, "compression_ratio": 1.2083333333333333, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1652.7000000000003, "end": 1653.5400000000002, "word": " It", "probability": 0.26806640625}, {"start": 1653.5400000000002, "end": 1654.38, "word": " refers", "probability": 0.71630859375}, {"start": 1654.38, "end": 1654.58, "word": " to", "probability": 0.970703125}, {"start": 1654.58, "end": 1654.76, "word": " an", "probability": 0.93896484375}, {"start": 1654.76, "end": 1655.08, "word": " action", "probability": 0.93017578125}, {"start": 1655.08, "end": 1657.02, "word": " that", "probability": 0.60693359375}, {"start": 1657.02, "end": 1659.26, "word": " was", "probability": 0.80126953125}, {"start": 1659.26, "end": 1659.44, "word": " to", "probability": 0.828125}, {"start": 1659.44, "end": 1659.84, "word": " happen", "probability": 0.91064453125}, {"start": 1659.84, "end": 1660.7, "word": " in", "probability": 0.94580078125}, {"start": 1660.7, "end": 1660.82, "word": " the", "probability": 0.92041015625}, {"start": 1660.82, "end": 1661.24, "word": " past.", "probability": 0.89306640625}, {"start": 1665.0, "end": 1665.84, "word": " My", "probability": 0.548828125}, {"start": 1665.84, "end": 1666.36, "word": " father", "probability": 0.857421875}, {"start": 1666.36, "end": 1666.82, "word": " or", "probability": 0.85986328125}, {"start": 1666.82, "end": 1667.16, "word": " dad", "probability": 0.798828125}, {"start": 1667.16, "end": 1667.64, "word": " recommended", "probability": 0.64306640625}, {"start": 1667.64, "end": 1667.94, "word": " me", "probability": 0.88916015625}, {"start": 1667.94, "end": 1668.12, "word": " to", "probability": 0.96484375}, {"start": 1668.12, "end": 1668.84, "word": " do", "probability": 0.64404296875}, {"start": 1668.84, "end": 1669.3, "word": " good", "probability": 0.90576171875}, {"start": 1669.3, "end": 1669.92, "word": " all", "probability": 0.9248046875}, {"start": 1669.92, "end": 1670.28, "word": " over", "probability": 0.9267578125}, {"start": 1670.28, "end": 1670.54, "word": " my", "probability": 0.96875}, {"start": 1670.54, "end": 1670.96, "word": " life.", "probability": 0.93212890625}], "temperature": 1.0}, {"id": 62, "seek": 170656, "start": 1680.8, "end": 1706.56, "text": " Now, we have the exemplative قد which refers to an action that is expected. Its construction is in the past, but it refers to future. قد قامت الصلاة قد قامت الصلاة The prayer is to be performed.", "tokens": [823, 11, 321, 362, 264, 24112, 1166, 12174, 3215, 597, 14942, 281, 364, 3069, 300, 307, 5176, 13, 6953, 6435, 307, 294, 264, 1791, 11, 457, 309, 14942, 281, 2027, 13, 12174, 3215, 12174, 10943, 2655, 31767, 15040, 3660, 12174, 3215, 12174, 10943, 2655, 31767, 15040, 3660, 440, 8767, 307, 281, 312, 10332, 13], "avg_logprob": -0.22556818452748387, "compression_ratio": 1.4350649350649352, "no_speech_prob": 0.0, "words": [{"start": 1680.7999999999997, "end": 1681.6799999999998, "word": " Now,", "probability": 0.8291015625}, {"start": 1681.6799999999998, "end": 1682.56, "word": " we", "probability": 0.91015625}, {"start": 1682.56, "end": 1682.96, "word": " have", "probability": 0.94921875}, {"start": 1682.96, "end": 1683.22, "word": " the", "probability": 0.88525390625}, {"start": 1683.22, "end": 1683.84, "word": " exemplative", "probability": 0.56103515625}, {"start": 1683.84, "end": 1684.3, "word": " قد", "probability": 0.482421875}, {"start": 1684.3, "end": 1684.6, "word": " which", "probability": 0.548828125}, {"start": 1684.6, "end": 1685.08, "word": " refers", "probability": 0.83642578125}, {"start": 1685.08, "end": 1685.3, "word": " to", "probability": 0.974609375}, {"start": 1685.3, "end": 1685.52, "word": " an", "probability": 0.9423828125}, {"start": 1685.52, "end": 1685.98, "word": " action", "probability": 0.939453125}, {"start": 1685.98, "end": 1687.0, "word": " that", "probability": 0.916015625}, {"start": 1687.0, "end": 1687.44, "word": " is", "probability": 0.955078125}, {"start": 1687.44, "end": 1688.7, "word": " expected.", "probability": 0.9111328125}, {"start": 1690.36, "end": 1691.24, "word": " Its", "probability": 0.3603515625}, {"start": 1691.24, "end": 1692.3, "word": " construction", "probability": 0.94189453125}, {"start": 1692.3, "end": 1692.82, "word": " is", "probability": 0.91943359375}, {"start": 1692.82, "end": 1693.04, "word": " in", "probability": 0.93701171875}, {"start": 1693.04, "end": 1693.18, "word": " the", "probability": 0.9208984375}, {"start": 1693.18, "end": 1693.62, "word": " past,", "probability": 0.8583984375}, {"start": 1694.0, "end": 1694.38, "word": " but", "probability": 0.921875}, {"start": 1694.38, "end": 1694.5, "word": " it", "probability": 0.8427734375}, {"start": 1694.5, "end": 1694.88, "word": " refers", "probability": 0.83251953125}, {"start": 1694.88, "end": 1695.26, "word": " to", "probability": 0.97021484375}, {"start": 1695.26, "end": 1696.44, "word": " future.", "probability": 0.74755859375}, {"start": 1697.76, "end": 1697.92, "word": " قد", "probability": 0.859130859375}, {"start": 1697.92, "end": 1698.42, "word": " قامت", "probability": 0.9708658854166666}, {"start": 1698.42, "end": 1700.42, "word": " الصلاة", "probability": 0.9794921875}, {"start": 1700.42, "end": 1703.34, "word": " قد", "probability": 0.6629638671875}, {"start": 1703.34, "end": 1703.78, "word": " قامت", "probability": 0.9900716145833334}, {"start": 1703.78, "end": 1704.24, "word": " الصلاة", "probability": 0.9921875}, {"start": 1704.24, "end": 1704.9, "word": " The", "probability": 0.55224609375}, {"start": 1704.9, "end": 1705.28, "word": " prayer", "probability": 0.8857421875}, {"start": 1705.28, "end": 1705.56, "word": " is", "probability": 0.94677734375}, {"start": 1705.56, "end": 1705.7, "word": " to", "probability": 0.97216796875}, {"start": 1705.7, "end": 1705.9, "word": " be", "probability": 0.9609375}, {"start": 1705.9, "end": 1706.56, "word": " performed.", "probability": 0.73388671875}], "temperature": 1.0}, {"id": 63, "seek": 173537, "start": 1708.91, "end": 1735.37, "text": " The action as you see, the form of the sentence is in the past. However, its meaning refers to imminent future, imminent future. استجيبوا لله والرسول إذا دعاكم لما يحييكم", "tokens": [440, 3069, 382, 291, 536, 11, 264, 1254, 295, 264, 8174, 307, 294, 264, 1791, 13, 2908, 11, 1080, 3620, 14942, 281, 44339, 2027, 11, 44339, 2027, 13, 44713, 7435, 1829, 3555, 14407, 24976, 3224, 16070, 2288, 3794, 12610, 11933, 15730, 11778, 3615, 995, 24793, 5296, 15042, 7251, 5016, 1829, 1829, 24793], "avg_logprob": -0.16863207547169812, "compression_ratio": 1.279503105590062, "no_speech_prob": 0.0, "words": [{"start": 1708.91, "end": 1709.13, "word": " The", "probability": 0.783203125}, {"start": 1709.13, "end": 1709.53, "word": " action", "probability": 0.9169921875}, {"start": 1709.53, "end": 1709.77, "word": " as", "probability": 0.6943359375}, {"start": 1709.77, "end": 1709.91, "word": " you", "probability": 0.96826171875}, {"start": 1709.91, "end": 1710.17, "word": " see,", "probability": 0.9287109375}, {"start": 1711.05, "end": 1711.19, "word": " the", "probability": 0.9033203125}, {"start": 1711.19, "end": 1711.49, "word": " form", "probability": 0.9248046875}, {"start": 1711.49, "end": 1711.61, "word": " of", "probability": 0.970703125}, {"start": 1711.61, "end": 1711.73, "word": " the", "probability": 0.91455078125}, {"start": 1711.73, "end": 1712.23, "word": " sentence", "probability": 0.9521484375}, {"start": 1712.23, "end": 1712.55, "word": " is", "probability": 0.89501953125}, {"start": 1712.55, "end": 1712.77, "word": " in", "probability": 0.9111328125}, {"start": 1712.77, "end": 1712.93, "word": " the", "probability": 0.927734375}, {"start": 1712.93, "end": 1713.37, "word": " past.", "probability": 0.857421875}, {"start": 1713.93, "end": 1714.23, "word": " However,", "probability": 0.892578125}, {"start": 1714.35, "end": 1714.57, "word": " its", "probability": 0.77001953125}, {"start": 1714.57, "end": 1714.89, "word": " meaning", "probability": 0.84521484375}, {"start": 1714.89, "end": 1715.31, "word": " refers", "probability": 0.87353515625}, {"start": 1715.31, "end": 1716.13, "word": " to", "probability": 0.97412109375}, {"start": 1716.13, "end": 1717.11, "word": " imminent", "probability": 0.73193359375}, {"start": 1717.11, "end": 1718.43, "word": " future,", "probability": 0.97802734375}, {"start": 1718.75, "end": 1719.05, "word": " imminent", "probability": 0.8974609375}, {"start": 1719.05, "end": 1719.71, "word": " future.", "probability": 0.98046875}, {"start": 1731.19, "end": 1731.91, "word": " استجيبوا", "probability": 0.84658203125}, {"start": 1731.91, "end": 1732.37, "word": " لله", "probability": 0.83349609375}, {"start": 1732.37, "end": 1733.13, "word": " والرسول", "probability": 0.9298095703125}, {"start": 1733.13, "end": 1733.49, "word": " إذا", "probability": 0.95556640625}, {"start": 1733.49, "end": 1734.19, "word": " دعاكم", "probability": 0.9903564453125}, {"start": 1734.19, "end": 1734.59, "word": " لما", "probability": 0.77783203125}, {"start": 1734.59, "end": 1735.37, "word": " يحييكم", "probability": 0.9265625}], "temperature": 1.0}, {"id": 64, "seek": 176407, "start": 1737.75, "end": 1764.07, "text": " Surah Al-Anfal, verse 24 from the Holy Quran. Give your response to Allah and his messenger when he calls you to that which will give you life. What do you call da'a?", "tokens": [6732, 545, 967, 12, 7828, 36474, 11, 7996, 4022, 490, 264, 6295, 19375, 13, 5303, 428, 4134, 281, 4574, 293, 702, 26599, 562, 415, 5498, 291, 281, 300, 597, 486, 976, 291, 993, 13, 708, 360, 291, 818, 1120, 6, 64, 30], "avg_logprob": -0.3157703377479731, "compression_ratio": 1.2651515151515151, "no_speech_prob": 0.0, "words": [{"start": 1737.75, "end": 1738.33, "word": " Surah", "probability": 0.6490478515625}, {"start": 1738.33, "end": 1738.49, "word": " Al", "probability": 0.57421875}, {"start": 1738.49, "end": 1738.97, "word": "-Anfal,", "probability": 0.86279296875}, {"start": 1739.61, "end": 1739.97, "word": " verse", "probability": 0.72802734375}, {"start": 1739.97, "end": 1740.67, "word": " 24", "probability": 0.9384765625}, {"start": 1740.67, "end": 1742.39, "word": " from", "probability": 0.541015625}, {"start": 1742.39, "end": 1742.59, "word": " the", "probability": 0.7109375}, {"start": 1742.59, "end": 1742.79, "word": " Holy", "probability": 0.6396484375}, {"start": 1742.79, "end": 1743.23, "word": " Quran.", "probability": 0.8076171875}, {"start": 1744.87, "end": 1745.17, "word": " Give", "probability": 0.301025390625}, {"start": 1745.17, "end": 1751.49, "word": " your", "probability": 0.775390625}, {"start": 1751.49, "end": 1752.03, "word": " response", "probability": 0.94189453125}, {"start": 1752.03, "end": 1752.23, "word": " to", "probability": 0.97412109375}, {"start": 1752.23, "end": 1752.63, "word": " Allah", "probability": 0.8798828125}, {"start": 1752.63, "end": 1753.01, "word": " and", "probability": 0.93359375}, {"start": 1753.01, "end": 1753.29, "word": " his", "probability": 0.401611328125}, {"start": 1753.29, "end": 1753.77, "word": " messenger", "probability": 0.69189453125}, {"start": 1753.77, "end": 1754.59, "word": " when", "probability": 0.82568359375}, {"start": 1754.59, "end": 1754.79, "word": " he", "probability": 0.93017578125}, {"start": 1754.79, "end": 1755.17, "word": " calls", "probability": 0.8916015625}, {"start": 1755.17, "end": 1755.51, "word": " you", "probability": 0.9638671875}, {"start": 1755.51, "end": 1755.85, "word": " to", "probability": 0.96484375}, {"start": 1755.85, "end": 1756.31, "word": " that", "probability": 0.943359375}, {"start": 1756.31, "end": 1756.69, "word": " which", "probability": 0.92529296875}, {"start": 1756.69, "end": 1756.97, "word": " will", "probability": 0.88232421875}, {"start": 1756.97, "end": 1757.33, "word": " give", "probability": 0.89697265625}, {"start": 1757.33, "end": 1757.49, "word": " you", "probability": 0.9638671875}, {"start": 1757.49, "end": 1758.05, "word": " life.", "probability": 0.93408203125}, {"start": 1762.33, "end": 1762.75, "word": " What", "probability": 0.442138671875}, {"start": 1762.75, "end": 1763.57, "word": " do", "probability": 0.70947265625}, {"start": 1763.57, "end": 1763.59, "word": " you", "probability": 0.8935546875}, {"start": 1763.59, "end": 1763.77, "word": " call", "probability": 0.9169921875}, {"start": 1763.77, "end": 1763.91, "word": " da", "probability": 0.13525390625}, {"start": 1763.91, "end": 1764.07, "word": "'a?", "probability": 0.731201171875}], "temperature": 1.0}, {"id": 65, "seek": 179022, "start": 1765.6, "end": 1790.22, "text": " What do you call it? Past or future? It is past, but it refers to the past, present and future. This construction is only available in Arabic, but not in other languages. Okay?", "tokens": [708, 360, 291, 818, 309, 30, 18408, 420, 2027, 30, 467, 307, 1791, 11, 457, 309, 14942, 281, 264, 1791, 11, 1974, 293, 2027, 13, 639, 6435, 307, 787, 2435, 294, 19938, 11, 457, 406, 294, 661, 8650, 13, 1033, 30], "avg_logprob": -0.21893601403349922, "compression_ratio": 1.3208955223880596, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1765.6, "end": 1765.82, "word": " What", "probability": 0.65380859375}, {"start": 1765.82, "end": 1765.94, "word": " do", "probability": 0.77880859375}, {"start": 1765.94, "end": 1766.0, "word": " you", "probability": 0.9365234375}, {"start": 1766.0, "end": 1766.24, "word": " call", "probability": 0.9111328125}, {"start": 1766.24, "end": 1766.5, "word": " it?", "probability": 0.951171875}, {"start": 1766.98, "end": 1767.36, "word": " Past", "probability": 0.8681640625}, {"start": 1767.36, "end": 1767.58, "word": " or", "probability": 0.92578125}, {"start": 1767.58, "end": 1768.1, "word": " future?", "probability": 0.68017578125}, {"start": 1768.56, "end": 1769.16, "word": " It", "probability": 0.64599609375}, {"start": 1769.16, "end": 1769.3, "word": " is", "probability": 0.80126953125}, {"start": 1769.3, "end": 1769.6, "word": " past,", "probability": 0.78271484375}, {"start": 1769.68, "end": 1769.8, "word": " but", "probability": 0.921875}, {"start": 1769.8, "end": 1769.98, "word": " it", "probability": 0.9482421875}, {"start": 1769.98, "end": 1770.4, "word": " refers", "probability": 0.81884765625}, {"start": 1770.4, "end": 1770.92, "word": " to", "probability": 0.97509765625}, {"start": 1770.92, "end": 1771.08, "word": " the", "probability": 0.1865234375}, {"start": 1771.08, "end": 1773.98, "word": " past,", "probability": 0.80126953125}, {"start": 1781.68, "end": 1782.12, "word": " present", "probability": 0.89404296875}, {"start": 1782.12, "end": 1783.0, "word": " and", "probability": 0.7763671875}, {"start": 1783.0, "end": 1783.52, "word": " future.", "probability": 0.9794921875}, {"start": 1784.12, "end": 1784.32, "word": " This", "probability": 0.68359375}, {"start": 1784.32, "end": 1784.84, "word": " construction", "probability": 0.93310546875}, {"start": 1784.84, "end": 1785.14, "word": " is", "probability": 0.9453125}, {"start": 1785.14, "end": 1785.4, "word": " only", "probability": 0.916015625}, {"start": 1785.4, "end": 1785.9, "word": " available", "probability": 0.841796875}, {"start": 1785.9, "end": 1786.16, "word": " in", "probability": 0.95263671875}, {"start": 1786.16, "end": 1786.48, "word": " Arabic,", "probability": 0.9267578125}, {"start": 1786.7, "end": 1786.8, "word": " but", "probability": 0.9130859375}, {"start": 1786.8, "end": 1787.06, "word": " not", "probability": 0.93359375}, {"start": 1787.06, "end": 1787.34, "word": " in", "probability": 0.94189453125}, {"start": 1787.34, "end": 1787.7, "word": " other", "probability": 0.880859375}, {"start": 1787.7, "end": 1788.88, "word": " languages.", "probability": 0.955078125}, {"start": 1789.64, "end": 1790.22, "word": " Okay?", "probability": 0.79052734375}], "temperature": 1.0}, {"id": 66, "seek": 182933, "start": 1805.37, "end": 1829.33, "text": " We can say, كاد زيد أن يأتي. How could you translate this? كاد زيد أن يأتي. زيد was about to come. كاد أو كان زيد على وشك أن يأتي. زيد was about to come. Okay.", "tokens": [492, 393, 584, 11, 9122, 18513, 30767, 25708, 14739, 7251, 10721, 31371, 13, 1012, 727, 291, 13799, 341, 30, 9122, 18513, 30767, 25708, 14739, 7251, 10721, 31371, 13, 30767, 25708, 390, 466, 281, 808, 13, 9122, 18513, 34051, 25961, 30767, 25708, 15844, 4032, 8592, 4117, 14739, 7251, 10721, 31371, 13, 30767, 25708, 390, 466, 281, 808, 13, 1033, 13], "avg_logprob": -0.209765621026357, "compression_ratio": 1.6384615384615384, "no_speech_prob": 0.0, "words": [{"start": 1805.37, "end": 1805.57, "word": " We", "probability": 0.78125}, {"start": 1805.57, "end": 1805.81, "word": " can", "probability": 0.93896484375}, {"start": 1805.81, "end": 1806.13, "word": " say,", "probability": 0.93310546875}, {"start": 1806.29, "end": 1806.53, "word": " كاد", "probability": 0.3134765625}, {"start": 1806.53, "end": 1806.95, "word": " زيد", "probability": 0.932373046875}, {"start": 1806.95, "end": 1807.31, "word": " أن", "probability": 0.27978515625}, {"start": 1807.31, "end": 1807.79, "word": " يأتي.", "probability": 0.9041341145833334}, {"start": 1808.27, "end": 1808.47, "word": " How", "probability": 0.697265625}, {"start": 1808.47, "end": 1808.65, "word": " could", "probability": 0.84619140625}, {"start": 1808.65, "end": 1808.79, "word": " you", "probability": 0.9697265625}, {"start": 1808.79, "end": 1809.13, "word": " translate", "probability": 0.82666015625}, {"start": 1809.13, "end": 1809.57, "word": " this?", "probability": 0.94580078125}, {"start": 1810.47, "end": 1811.21, "word": " كاد", "probability": 0.5413818359375}, {"start": 1811.21, "end": 1811.59, "word": " زيد", "probability": 0.9326171875}, {"start": 1811.59, "end": 1811.91, "word": " أن", "probability": 0.84716796875}, {"start": 1811.91, "end": 1812.61, "word": " يأتي.", "probability": 0.9597981770833334}, {"start": 1815.73, "end": 1816.17, "word": " زيد", "probability": 0.654052734375}, {"start": 1816.17, "end": 1816.43, "word": " was", "probability": 0.84912109375}, {"start": 1816.43, "end": 1816.91, "word": " about", "probability": 0.93603515625}, {"start": 1816.91, "end": 1817.33, "word": " to", "probability": 0.98291015625}, {"start": 1817.33, "end": 1818.25, "word": " come.", "probability": 0.89697265625}, {"start": 1820.69, "end": 1821.27, "word": " كاد", "probability": 0.674072265625}, {"start": 1821.27, "end": 1821.69, "word": " أو", "probability": 0.7529296875}, {"start": 1821.69, "end": 1822.09, "word": " كان", "probability": 0.9130859375}, {"start": 1822.09, "end": 1822.51, "word": " زيد", "probability": 0.982666015625}, {"start": 1822.51, "end": 1822.87, "word": " على", "probability": 0.84814453125}, {"start": 1822.87, "end": 1823.49, "word": " وشك", "probability": 0.9519856770833334}, {"start": 1823.49, "end": 1823.71, "word": " أن", "probability": 0.95458984375}, {"start": 1823.71, "end": 1824.15, "word": " يأتي.", "probability": 0.9767252604166666}, {"start": 1825.21, "end": 1825.85, "word": " زيد", "probability": 0.889892578125}, {"start": 1825.85, "end": 1827.51, "word": " was", "probability": 0.9619140625}, {"start": 1827.51, "end": 1827.89, "word": " about", "probability": 0.93115234375}, {"start": 1827.89, "end": 1828.21, "word": " to", "probability": 0.9755859375}, {"start": 1828.21, "end": 1828.47, "word": " come.", "probability": 0.88330078125}, {"start": 1829.05, "end": 1829.33, "word": " Okay.", "probability": 0.84326171875}], "temperature": 1.0}, {"id": 67, "seek": 183933, "start": 1835.39, "end": 1839.33, "text": " So both are translated by about two.", "tokens": [407, 1293, 366, 16805, 538, 466, 732, 13], "avg_logprob": -0.203125, "compression_ratio": 0.8222222222222222, "no_speech_prob": 0.0, "words": [{"start": 1835.39, "end": 1835.67, "word": " So", "probability": 0.81787109375}, {"start": 1835.67, "end": 1836.05, "word": " both", "probability": 0.68603515625}, {"start": 1836.05, "end": 1836.23, "word": " are", "probability": 0.9140625}, {"start": 1836.23, "end": 1836.75, "word": " translated", "probability": 0.830078125}, {"start": 1836.75, "end": 1837.23, "word": " by", "probability": 0.8720703125}, {"start": 1837.23, "end": 1839.01, "word": " about", "probability": 0.72802734375}, {"start": 1839.01, "end": 1839.33, "word": " two.", "probability": 0.8310546875}], "temperature": 1.0}], "language": "en", "language_probability": 1.0, "duration": 1848.935375, "duration_after_vad": 1695.084093749998}
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+{"segments": [{"id": 1, "seek": 2208, "start": 15.72, "end": 22.08, "text": " They are going to see the intonation is moving. In English,", "tokens": [814, 366, 516, 281, 536, 264, 560, 266, 399, 307, 2684, 13, 682, 3669, 11], "avg_logprob": -0.6166991963982582, "compression_ratio": 0.9090909090909091, "no_speech_prob": 2.205371856689453e-06, "words": [{"start": 15.719999999999995, "end": 16.639999999999997, "word": " They", "probability": 0.0213623046875}, {"start": 16.639999999999997, "end": 17.56, "word": " are", "probability": 0.70361328125}, {"start": 17.56, "end": 17.78, "word": " going", "probability": 0.93603515625}, {"start": 17.78, "end": 17.92, "word": " to", "probability": 0.97021484375}, {"start": 17.92, "end": 18.1, "word": " see", "probability": 0.89990234375}, {"start": 18.1, "end": 18.26, "word": " the", "probability": 0.7412109375}, {"start": 18.26, "end": 18.74, "word": " intonation", "probability": 0.9173177083333334}, {"start": 18.74, "end": 19.0, "word": " is", "probability": 0.241455078125}, {"start": 19.0, "end": 19.46, "word": " moving.", "probability": 0.86962890625}, {"start": 21.16, "end": 21.72, "word": " In", "probability": 0.1925048828125}, {"start": 21.72, "end": 22.08, "word": " English,", "probability": 0.9208984375}], "temperature": 1.0}, {"id": 2, "seek": 5203, "start": 29.07, "end": 52.03, "text": " We have the intonation system which has different functions. It is the difference in the shape of the pitch, either high or rise or fall. We have according to Konar, we have only two types of intonation, rising intonation and falling intonation.", "tokens": [492, 362, 264, 560, 266, 399, 1185, 597, 575, 819, 6828, 13, 467, 307, 264, 2649, 294, 264, 3909, 295, 264, 7293, 11, 2139, 1090, 420, 6272, 420, 2100, 13, 492, 362, 4650, 281, 12718, 289, 11, 321, 362, 787, 732, 3467, 295, 560, 266, 399, 11, 11636, 560, 266, 399, 293, 7440, 560, 266, 399, 13], "avg_logprob": -0.20325969904661179, "compression_ratio": 1.662162162162162, "no_speech_prob": 4.76837158203125e-07, "words": [{"start": 29.07, "end": 29.29, "word": " We", "probability": 0.576171875}, {"start": 29.29, "end": 29.53, "word": " have", "probability": 0.94384765625}, {"start": 29.53, "end": 29.69, "word": " the", "probability": 0.5546875}, {"start": 29.69, "end": 30.15, "word": " intonation", "probability": 0.9607747395833334}, {"start": 30.15, "end": 30.65, "word": " system", "probability": 0.89697265625}, {"start": 30.65, "end": 30.93, "word": " which", "probability": 0.4482421875}, {"start": 30.93, "end": 31.09, "word": " has", "probability": 0.47412109375}, {"start": 31.09, "end": 31.75, "word": " different", "probability": 0.82763671875}, {"start": 31.75, "end": 33.09, "word": " functions.", "probability": 0.91845703125}, {"start": 33.91, "end": 34.05, "word": " It", "probability": 0.89404296875}, {"start": 34.05, "end": 34.33, "word": " is", "probability": 0.923828125}, {"start": 34.33, "end": 35.65, "word": " the", "probability": 0.9013671875}, {"start": 35.65, "end": 36.31, "word": " difference", "probability": 0.859375}, {"start": 36.31, "end": 36.81, "word": " in", "probability": 0.94482421875}, {"start": 36.81, "end": 38.19, "word": " the", "probability": 0.88623046875}, {"start": 38.19, "end": 38.75, "word": " shape", "probability": 0.90771484375}, {"start": 38.75, "end": 38.95, "word": " of", "probability": 0.96875}, {"start": 38.95, "end": 39.13, "word": " the", "probability": 0.91552734375}, {"start": 39.13, "end": 39.51, "word": " pitch,", "probability": 0.90087890625}, {"start": 40.23, "end": 40.59, "word": " either", "probability": 0.94091796875}, {"start": 40.59, "end": 41.11, "word": " high", "probability": 0.90625}, {"start": 41.11, "end": 42.25, "word": " or", "probability": 0.84326171875}, {"start": 42.25, "end": 42.95, "word": " rise", "probability": 0.8974609375}, {"start": 42.95, "end": 43.27, "word": " or", "probability": 0.9521484375}, {"start": 43.27, "end": 43.67, "word": " fall.", "probability": 0.876953125}, {"start": 44.11, "end": 44.29, "word": " We", "probability": 0.6455078125}, {"start": 44.29, "end": 44.51, "word": " have", "probability": 0.9462890625}, {"start": 44.51, "end": 44.95, "word": " according", "probability": 0.53955078125}, {"start": 44.95, "end": 45.23, "word": " to", "probability": 0.970703125}, {"start": 45.23, "end": 45.65, "word": " Konar,", "probability": 0.50244140625}, {"start": 46.13, "end": 46.41, "word": " we", "probability": 0.8642578125}, {"start": 46.41, "end": 46.59, "word": " have", "probability": 0.9267578125}, {"start": 46.59, "end": 46.89, "word": " only", "probability": 0.91455078125}, {"start": 46.89, "end": 47.15, "word": " two", "probability": 0.92333984375}, {"start": 47.15, "end": 47.57, "word": " types", "probability": 0.82568359375}, {"start": 47.57, "end": 47.75, "word": " of", "probability": 0.96826171875}, {"start": 47.75, "end": 48.31, "word": " intonation,", "probability": 0.96484375}, {"start": 49.05, "end": 49.41, "word": " rising", "probability": 0.92138671875}, {"start": 49.41, "end": 50.07, "word": " intonation", "probability": 0.95947265625}, {"start": 50.07, "end": 50.93, "word": " and", "probability": 0.55615234375}, {"start": 50.93, "end": 51.47, "word": " falling", "probability": 0.52001953125}, {"start": 51.47, "end": 52.03, "word": " intonation.", "probability": 0.86669921875}], "temperature": 1.0}, {"id": 3, "seek": 8193, "start": 55.43, "end": 81.93, "text": " Harma and Hajjaj just introduced six types of intonation in English. At the same time, you have three intonations in Arabic. The systems of both English and Arabic intonations are completely different. So we have our students move the pitch system of Arabic into English, okay?", "tokens": [3653, 1696, 293, 43347, 73, 1805, 445, 7268, 2309, 3467, 295, 560, 266, 399, 294, 3669, 13, 1711, 264, 912, 565, 11, 291, 362, 1045, 560, 266, 763, 294, 19938, 13, 440, 3652, 295, 1293, 3669, 293, 19938, 560, 266, 763, 366, 2584, 819, 13, 407, 321, 362, 527, 1731, 1286, 264, 7293, 1185, 295, 19938, 666, 3669, 11, 1392, 30], "avg_logprob": -0.18157762625525076, "compression_ratio": 1.5977011494252873, "no_speech_prob": 3.5762786865234375e-07, "words": [{"start": 55.43, "end": 55.81, "word": " Harma", "probability": 0.5103759765625}, {"start": 55.81, "end": 56.05, "word": " and", "probability": 0.82666015625}, {"start": 56.05, "end": 56.73, "word": " Hajjaj", "probability": 0.7063802083333334}, {"start": 56.73, "end": 58.21, "word": " just", "probability": 0.5927734375}, {"start": 58.21, "end": 58.69, "word": " introduced", "probability": 0.73681640625}, {"start": 58.69, "end": 59.83, "word": " six", "probability": 0.931640625}, {"start": 59.83, "end": 60.21, "word": " types", "probability": 0.81201171875}, {"start": 60.21, "end": 60.39, "word": " of", "probability": 0.97021484375}, {"start": 60.39, "end": 60.85, "word": " intonation", "probability": 0.9733072916666666}, {"start": 60.85, "end": 61.07, "word": " in", "probability": 0.95166015625}, {"start": 61.07, "end": 61.45, "word": " English.", "probability": 0.97705078125}, {"start": 62.91, "end": 63.05, "word": " At", "probability": 0.85400390625}, {"start": 63.05, "end": 63.19, "word": " the", "probability": 0.9189453125}, {"start": 63.19, "end": 63.39, "word": " same", "probability": 0.89501953125}, {"start": 63.39, "end": 63.85, "word": " time,", "probability": 0.890625}, {"start": 64.91, "end": 64.97, "word": " you", "probability": 0.51123046875}, {"start": 64.97, "end": 65.13, "word": " have", "probability": 0.94140625}, {"start": 65.13, "end": 65.35, "word": " three", "probability": 0.931640625}, {"start": 65.35, "end": 66.13, "word": " intonations", "probability": 0.95654296875}, {"start": 66.13, "end": 66.81, "word": " in", "probability": 0.89599609375}, {"start": 66.81, "end": 67.11, "word": " Arabic.", "probability": 0.86474609375}, {"start": 67.97, "end": 68.37, "word": " The", "probability": 0.8193359375}, {"start": 68.37, "end": 68.99, "word": " systems", "probability": 0.9208984375}, {"start": 68.99, "end": 69.31, "word": " of", "probability": 0.8916015625}, {"start": 69.31, "end": 69.55, "word": " both", "probability": 0.83349609375}, {"start": 69.55, "end": 69.95, "word": " English", "probability": 0.97509765625}, {"start": 69.95, "end": 70.25, "word": " and", "probability": 0.93896484375}, {"start": 70.25, "end": 70.59, "word": " Arabic", "probability": 0.9150390625}, {"start": 70.59, "end": 71.33, "word": " intonations", "probability": 0.8291015625}, {"start": 71.33, "end": 72.17, "word": " are", "probability": 0.92919921875}, {"start": 72.17, "end": 72.63, "word": " completely", "probability": 0.74169921875}, {"start": 72.63, "end": 73.17, "word": " different.", "probability": 0.88134765625}, {"start": 74.47, "end": 74.71, "word": " So", "probability": 0.8369140625}, {"start": 74.71, "end": 74.87, "word": " we", "probability": 0.8037109375}, {"start": 74.87, "end": 75.05, "word": " have", "probability": 0.72412109375}, {"start": 75.05, "end": 75.31, "word": " our", "probability": 0.62646484375}, {"start": 75.31, "end": 75.87, "word": " students", "probability": 0.9755859375}, {"start": 75.87, "end": 76.91, "word": " move", "probability": 0.92431640625}, {"start": 76.91, "end": 77.59, "word": " the", "probability": 0.8759765625}, {"start": 77.59, "end": 78.57, "word": " pitch", "probability": 0.9267578125}, {"start": 78.57, "end": 79.43, "word": " system", "probability": 0.9453125}, {"start": 79.43, "end": 79.67, "word": " of", "probability": 0.86962890625}, {"start": 79.67, "end": 80.03, "word": " Arabic", "probability": 0.93603515625}, {"start": 80.03, "end": 80.41, "word": " into", "probability": 0.81787109375}, {"start": 80.41, "end": 80.93, "word": " English,", "probability": 0.97607421875}, {"start": 81.37, "end": 81.93, "word": " okay?", "probability": 0.76513671875}], "temperature": 1.0}, {"id": 4, "seek": 11394, "start": 84.02, "end": 113.94, "text": " speaking English in a heavy accent. So we need to touch the intonation system of English to avoid these mistakes as much as we can. Okay? Now, we have the function of the intonation system. Intonation is a grammatical function. So to distinguish between the declarative sentences and questions, imperatives, we need", "tokens": [4124, 3669, 294, 257, 4676, 11982, 13, 407, 321, 643, 281, 2557, 264, 560, 266, 399, 1185, 295, 3669, 281, 5042, 613, 8038, 382, 709, 382, 321, 393, 13, 1033, 30, 823, 11, 321, 362, 264, 2445, 295, 264, 560, 266, 399, 1185, 13, 5681, 266, 399, 307, 257, 17570, 267, 804, 2445, 13, 407, 281, 20206, 1296, 264, 16694, 1166, 16579, 293, 1651, 11, 10100, 4884, 11, 321, 643], "avg_logprob": -0.16813380197739938, "compression_ratio": 1.6122448979591837, "no_speech_prob": 7.31348991394043e-05, "words": [{"start": 84.02, "end": 84.64, "word": " speaking", "probability": 0.216552734375}, {"start": 84.64, "end": 85.42, "word": " English", "probability": 0.9248046875}, {"start": 85.42, "end": 86.18, "word": " in", "probability": 0.83056640625}, {"start": 86.18, "end": 86.28, "word": " a", "probability": 0.96435546875}, {"start": 86.28, "end": 86.58, "word": " heavy", "probability": 0.8623046875}, {"start": 86.58, "end": 87.0, "word": " accent.", "probability": 0.94775390625}, {"start": 87.5, "end": 87.88, "word": " So", "probability": 0.83251953125}, {"start": 87.88, "end": 88.06, "word": " we", "probability": 0.7998046875}, {"start": 88.06, "end": 88.3, "word": " need", "probability": 0.8994140625}, {"start": 88.3, "end": 88.52, "word": " to", "probability": 0.958984375}, {"start": 88.52, "end": 88.98, "word": " touch", "probability": 0.6943359375}, {"start": 88.98, "end": 89.2, "word": " the", "probability": 0.85009765625}, {"start": 89.2, "end": 89.6, "word": " intonation", "probability": 0.8977864583333334}, {"start": 89.6, "end": 90.04, "word": " system", "probability": 0.9296875}, {"start": 90.04, "end": 90.22, "word": " of", "probability": 0.92333984375}, {"start": 90.22, "end": 90.56, "word": " English", "probability": 0.9775390625}, {"start": 90.56, "end": 91.22, "word": " to", "probability": 0.89013671875}, {"start": 91.22, "end": 91.74, "word": " avoid", "probability": 0.9208984375}, {"start": 91.74, "end": 92.3, "word": " these", "probability": 0.85986328125}, {"start": 92.3, "end": 93.1, "word": " mistakes", "probability": 0.8935546875}, {"start": 93.1, "end": 93.92, "word": " as", "probability": 0.5673828125}, {"start": 93.92, "end": 94.16, "word": " much", "probability": 0.9052734375}, {"start": 94.16, "end": 94.32, "word": " as", "probability": 0.9638671875}, {"start": 94.32, "end": 94.5, "word": " we", "probability": 0.9423828125}, {"start": 94.5, "end": 94.7, "word": " can.", "probability": 0.95068359375}, {"start": 95.68, "end": 95.96, "word": " Okay?", "probability": 0.55712890625}, {"start": 96.72, "end": 97.6, "word": " Now,", "probability": 0.89453125}, {"start": 98.06, "end": 98.56, "word": " we", "probability": 0.95654296875}, {"start": 98.56, "end": 98.72, "word": " have", "probability": 0.94970703125}, {"start": 98.72, "end": 98.88, "word": " the", "probability": 0.81787109375}, {"start": 98.88, "end": 99.3, "word": " function", "probability": 0.95849609375}, {"start": 99.3, "end": 99.54, "word": " of", "probability": 0.96728515625}, {"start": 99.54, "end": 99.7, "word": " the", "probability": 0.85595703125}, {"start": 99.7, "end": 100.08, "word": " intonation", "probability": 0.9514973958333334}, {"start": 100.08, "end": 100.6, "word": " system.", "probability": 0.9462890625}, {"start": 102.08, "end": 102.98, "word": " Intonation", "probability": 0.95849609375}, {"start": 102.98, "end": 103.96, "word": " is", "probability": 0.947265625}, {"start": 103.96, "end": 104.16, "word": " a", "probability": 0.94189453125}, {"start": 104.16, "end": 104.76, "word": " grammatical", "probability": 0.9490559895833334}, {"start": 104.76, "end": 105.22, "word": " function.", "probability": 0.9638671875}, {"start": 106.38, "end": 106.74, "word": " So", "probability": 0.9326171875}, {"start": 106.74, "end": 107.02, "word": " to", "probability": 0.6923828125}, {"start": 107.02, "end": 107.4, "word": " distinguish", "probability": 0.9130859375}, {"start": 107.4, "end": 107.96, "word": " between", "probability": 0.8662109375}, {"start": 107.96, "end": 108.16, "word": " the", "probability": 0.59912109375}, {"start": 108.16, "end": 108.62, "word": " declarative", "probability": 0.858154296875}, {"start": 108.62, "end": 109.22, "word": " sentences", "probability": 0.9482421875}, {"start": 109.22, "end": 110.34, "word": " and", "probability": 0.90673828125}, {"start": 110.34, "end": 111.32, "word": " questions,", "probability": 0.82763671875}, {"start": 111.98, "end": 112.68, "word": " imperatives,", "probability": 0.923828125}, {"start": 113.36, "end": 113.58, "word": " we", "probability": 0.9296875}, {"start": 113.58, "end": 113.94, "word": " need", "probability": 0.9189453125}], "temperature": 1.0}, {"id": 5, "seek": 14208, "start": 115.82, "end": 142.08, "text": " For the declarative sentences, they are always pronounced or mostly pronounced in falling intonation at the end of the sentence. Okay? Rise, fall. However, in misnomer questions, for example, we have", "tokens": [1171, 264, 16694, 1166, 16579, 11, 436, 366, 1009, 23155, 420, 5240, 23155, 294, 7440, 560, 266, 399, 412, 264, 917, 295, 264, 8174, 13, 1033, 30, 34482, 11, 2100, 13, 2908, 11, 294, 3346, 77, 14301, 1651, 11, 337, 1365, 11, 321, 362], "avg_logprob": -0.37569445768992105, "compression_ratio": 1.3888888888888888, "no_speech_prob": 1.430511474609375e-06, "words": [{"start": 115.82000000000002, "end": 116.86000000000001, "word": " For", "probability": 0.08917236328125}, {"start": 116.86000000000001, "end": 117.9, "word": " the", "probability": 0.494140625}, {"start": 117.9, "end": 118.44, "word": " declarative", "probability": 0.955810546875}, {"start": 118.44, "end": 119.24, "word": " sentences,", "probability": 0.9423828125}, {"start": 119.94, "end": 120.4, "word": " they", "probability": 0.85546875}, {"start": 120.4, "end": 120.68, "word": " are", "probability": 0.9228515625}, {"start": 120.68, "end": 121.36, "word": " always", "probability": 0.84423828125}, {"start": 121.36, "end": 122.46, "word": " pronounced", "probability": 0.76806640625}, {"start": 122.46, "end": 122.88, "word": " or", "probability": 0.49365234375}, {"start": 122.88, "end": 123.26, "word": " mostly", "probability": 0.8505859375}, {"start": 123.26, "end": 123.74, "word": " pronounced", "probability": 0.83251953125}, {"start": 123.74, "end": 124.3, "word": " in", "probability": 0.5859375}, {"start": 124.3, "end": 125.26, "word": " falling", "probability": 0.19287109375}, {"start": 125.26, "end": 126.06, "word": " intonation", "probability": 0.9029947916666666}, {"start": 126.06, "end": 126.3, "word": " at", "probability": 0.93359375}, {"start": 126.3, "end": 126.44, "word": " the", "probability": 0.9228515625}, {"start": 126.44, "end": 126.64, "word": " end", "probability": 0.90673828125}, {"start": 126.64, "end": 126.76, "word": " of", "probability": 0.96240234375}, {"start": 126.76, "end": 126.88, "word": " the", "probability": 0.84765625}, {"start": 126.88, "end": 127.4, "word": " sentence.", "probability": 0.9365234375}, {"start": 128.38, "end": 128.66, "word": " Okay?", "probability": 0.369873046875}, {"start": 131.56, "end": 132.18, "word": " Rise,", "probability": 0.77685546875}, {"start": 132.78, "end": 132.88, "word": " fall.", "probability": 0.77392578125}, {"start": 134.2, "end": 134.58, "word": " However,", "probability": 0.7763671875}, {"start": 136.56, "end": 136.86, "word": " in", "probability": 0.888671875}, {"start": 136.86, "end": 137.56, "word": " misnomer", "probability": 0.52459716796875}, {"start": 137.56, "end": 138.04, "word": " questions,", "probability": 0.9033203125}, {"start": 138.16, "end": 138.22, "word": " for", "probability": 0.935546875}, {"start": 138.22, "end": 138.56, "word": " example,", "probability": 0.9189453125}, {"start": 140.0, "end": 141.64, "word": " we", "probability": 0.92333984375}, {"start": 141.64, "end": 142.08, "word": " have", "probability": 0.94580078125}], "temperature": 1.0}, {"id": 6, "seek": 15637, "start": 152.81, "end": 156.37, "text": " We have four pitches in English, this is the low one", "tokens": [492, 362, 1451, 43110, 294, 3669, 11, 341, 307, 264, 2295, 472], "avg_logprob": -0.5480769230769231, "compression_ratio": 0.9137931034482759, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 152.80999999999997, "end": 153.39, "word": " We", "probability": 0.056976318359375}, {"start": 153.39, "end": 153.97, "word": " have", "probability": 0.84521484375}, {"start": 153.97, "end": 154.33, "word": " four", "probability": 0.6298828125}, {"start": 154.33, "end": 154.69, "word": " pitches", "probability": 0.68896484375}, {"start": 154.69, "end": 155.11, "word": " in", "probability": 0.88330078125}, {"start": 155.11, "end": 155.47, "word": " English,", "probability": 0.96533203125}, {"start": 155.59, "end": 155.69, "word": " this", "probability": 0.6484375}, {"start": 155.69, "end": 155.81, "word": " is", "probability": 0.94921875}, {"start": 155.81, "end": 155.95, "word": " the", "probability": 0.81884765625}, {"start": 155.95, "end": 156.15, "word": " low", "probability": 0.84765625}, {"start": 156.15, "end": 156.37, "word": " one", "probability": 0.9150390625}], "temperature": 1.0}, {"id": 7, "seek": 18688, "start": 158.96, "end": 186.88, "text": " High pitch, rising pitch. And we refer to them as number one, low pitch, number two, medium, number three, high pitch, number four, rise. So we have the rising pitch number four. 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The reluctant questions are also 2, 3, 1. Mid, high, low. The degenerative sentences are 2, 3, 1. 2, 3, 1. Okay? Mid, high, low. 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Unless you emphasize a sentence or any word in a sentence, then you have it in high pitch. So it becomes two, three, one. This is for the yes, no questions. We have the two question. 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Now we let you see the native speakers", "tokens": [407, 321, 643, 281, 2557, 439, 613, 3179, 295, 39772, 293, 536, 577, 393, 321, 19567, 3669, 588, 8195, 293, 19565, 13, 823, 321, 718, 291, 536, 264, 8470, 9518], "avg_logprob": -0.3009072522963247, "compression_ratio": 1.28099173553719, "no_speech_prob": 7.748603820800781e-07, "words": [{"start": 247.82999999999998, "end": 248.91, "word": " So", "probability": 0.042144775390625}, {"start": 248.91, "end": 249.99, "word": " we", "probability": 0.640625}, {"start": 249.99, "end": 250.21, "word": " need", "probability": 0.84912109375}, {"start": 250.21, "end": 250.35, "word": " to", "probability": 0.9599609375}, {"start": 250.35, "end": 250.65, "word": " touch", "probability": 0.83154296875}, {"start": 250.65, "end": 251.55, "word": " all", "probability": 0.783203125}, {"start": 251.55, "end": 251.93, "word": " these", "probability": 0.85302734375}, {"start": 251.93, "end": 252.53, "word": " areas", "probability": 0.93603515625}, {"start": 252.53, "end": 253.47, "word": " of", "probability": 0.86474609375}, {"start": 253.47, "end": 253.91, "word": " Indonesian", "probability": 0.591796875}, {"start": 253.91, "end": 254.99, "word": " and", "probability": 0.71337890625}, {"start": 254.99, "end": 255.35, "word": " see", "probability": 0.91552734375}, {"start": 255.35, "end": 255.93, "word": " how", "probability": 0.9013671875}, {"start": 255.93, "end": 256.25, "word": " can", "probability": 0.84033203125}, {"start": 256.25, "end": 256.45, "word": " we", "probability": 0.9521484375}, {"start": 256.45, "end": 257.05, "word": " pronounce", "probability": 0.89794921875}, {"start": 257.05, "end": 258.59, "word": " English", "probability": 0.943359375}, {"start": 258.59, "end": 259.01, "word": " very", "probability": 0.81005859375}, {"start": 259.01, "end": 259.55, "word": " naturally", "probability": 0.87109375}, {"start": 259.55, "end": 261.53, "word": " and", "probability": 0.6708984375}, {"start": 261.53, "end": 263.61, "word": " smoothly.", "probability": 0.8515625}, {"start": 264.87, "end": 265.39, "word": " Now", "probability": 0.90771484375}, {"start": 265.39, "end": 265.55, "word": " we", "probability": 0.46435546875}, {"start": 265.55, "end": 265.75, "word": " let", "probability": 0.8291015625}, {"start": 265.75, "end": 266.49, "word": " you", "probability": 0.9208984375}, {"start": 266.49, "end": 266.95, "word": " see", "probability": 0.9208984375}, {"start": 266.95, "end": 268.87, "word": " the", "probability": 0.8388671875}, {"start": 268.87, "end": 269.21, "word": " native", "probability": 0.8271484375}, {"start": 269.21, "end": 269.75, "word": " speakers", "probability": 0.87353515625}], "temperature": 1.0}, {"id": 11, "seek": 29631, "start": 271.53, "end": 296.31, "text": " of English and how intonation is pronounced. So listen to this lesson about intonation. English Pronunciation Lesson 10 Topic Intonation", "tokens": [295, 3669, 293, 577, 560, 266, 399, 307, 23155, 13, 407, 2140, 281, 341, 6898, 466, 560, 266, 399, 13, 3669, 45496, 18649, 266, 1266, 8840, 299, 5681, 266, 399], "avg_logprob": -0.1490675441680416, "compression_ratio": 1.37, "no_speech_prob": 2.205371856689453e-06, "words": [{"start": 271.53, "end": 271.79, "word": " of", "probability": 0.62890625}, {"start": 271.79, "end": 272.25, "word": " English", "probability": 0.97021484375}, {"start": 272.25, "end": 274.29, "word": " and", "probability": 0.7568359375}, {"start": 274.29, "end": 274.67, "word": " how", "probability": 0.9423828125}, {"start": 274.67, "end": 275.35, "word": " intonation", "probability": 0.9718424479166666}, {"start": 275.35, "end": 275.75, "word": " is", "probability": 0.95361328125}, {"start": 275.75, "end": 276.21, "word": " pronounced.", "probability": 0.7724609375}, {"start": 279.01, "end": 280.41, "word": " So", "probability": 0.9208984375}, {"start": 280.41, "end": 280.79, "word": " listen", "probability": 0.67919921875}, {"start": 280.79, "end": 281.71, "word": " to", "probability": 0.91455078125}, {"start": 281.71, "end": 282.15, "word": " this", "probability": 0.9482421875}, {"start": 282.15, "end": 282.89, "word": " lesson", "probability": 0.900390625}, {"start": 282.89, "end": 283.27, "word": " about", "probability": 0.900390625}, {"start": 283.27, "end": 283.95, "word": " intonation.", "probability": 0.9622395833333334}, {"start": 289.45, "end": 290.85, "word": " English", "probability": 0.865234375}, {"start": 290.85, "end": 291.59, "word": " Pronunciation", "probability": 0.74267578125}, {"start": 291.59, "end": 292.55, "word": " Lesson", "probability": 0.751953125}, {"start": 292.55, "end": 292.97, "word": " 10", "probability": 0.8115234375}, {"start": 292.97, "end": 295.21, "word": " Topic", "probability": 0.804443359375}, {"start": 295.21, "end": 296.31, "word": " Intonation", "probability": 0.8826497395833334}], "temperature": 1.0}, {"id": 12, "seek": 33363, "start": 332.27, "end": 333.63, "text": " I'm going to try one of the most popular ones.", "tokens": [286, 478, 516, 281, 853, 472, 295, 264, 881, 3743, 2306, 13], "avg_logprob": -1.1983173443720891, "compression_ratio": 0.8867924528301887, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 332.27, "end": 332.51, "word": " I'm", "probability": 0.1136474609375}, {"start": 332.51, "end": 332.59, "word": " going", "probability": 0.25732421875}, {"start": 332.59, "end": 332.67, "word": " to", "probability": 0.962890625}, {"start": 332.67, "end": 332.75, "word": " try", "probability": 0.150634765625}, {"start": 332.75, "end": 332.91, "word": " one", "probability": 0.148193359375}, {"start": 332.91, "end": 333.03, "word": " of", "probability": 0.76318359375}, {"start": 333.03, "end": 333.09, "word": " the", "probability": 0.4208984375}, {"start": 333.09, "end": 333.19, "word": " most", "probability": 0.381103515625}, {"start": 333.19, "end": 333.39, "word": " popular", "probability": 0.84619140625}, {"start": 333.39, "end": 333.63, "word": " ones.", "probability": 0.09429931640625}], "temperature": 1.0}, {"id": 13, "seek": 36292, "start": 338.9, "end": 362.92, "text": " English Pronunciation, Lesson 10. Topic, Intonation. Part 4. Exercise 5. Listening Task. Listen to a few of the questions you heard in the interview.", "tokens": [3669, 45496, 11, 18649, 266, 1266, 13, 8840, 299, 11, 5681, 266, 399, 13, 4100, 1017, 13, 44307, 1025, 13, 49321, 30428, 13, 7501, 281, 257, 1326, 295, 264, 1651, 291, 2198, 294, 264, 4049, 13], "avg_logprob": -0.1797930807680697, "compression_ratio": 1.2096774193548387, "no_speech_prob": 3.331899642944336e-05, "words": [{"start": 338.90000000000003, "end": 339.8, "word": " English", "probability": 0.94140625}, {"start": 339.8, "end": 340.66, "word": " Pronunciation,", "probability": 0.73583984375}, {"start": 341.1, "end": 341.42, "word": " Lesson", "probability": 0.828369140625}, {"start": 341.42, "end": 341.84, "word": " 10.", "probability": 0.80078125}, {"start": 343.38, "end": 344.08, "word": " Topic,", "probability": 0.936279296875}, {"start": 344.46, "end": 345.3, "word": " Intonation.", "probability": 0.8779296875}, {"start": 347.16, "end": 347.44, "word": " Part", "probability": 0.72802734375}, {"start": 347.44, "end": 348.0, "word": " 4.", "probability": 0.47265625}, {"start": 353.82, "end": 354.64, "word": " Exercise", "probability": 0.896484375}, {"start": 354.64, "end": 355.46, "word": " 5.", "probability": 0.9638671875}, {"start": 357.94, "end": 358.58, "word": " Listening", "probability": 0.77392578125}, {"start": 358.58, "end": 359.14, "word": " Task.", "probability": 0.77685546875}, {"start": 360.0, "end": 360.3, "word": " Listen", "probability": 0.73388671875}, {"start": 360.3, "end": 360.6, "word": " to", "probability": 0.97265625}, {"start": 360.6, "end": 360.76, "word": " a", "probability": 0.98046875}, {"start": 360.76, "end": 360.9, "word": " few", "probability": 0.90673828125}, {"start": 360.9, "end": 361.08, "word": " of", "probability": 0.95068359375}, {"start": 361.08, "end": 361.18, "word": " the", "probability": 0.916015625}, {"start": 361.18, "end": 361.66, "word": " questions", "probability": 0.9501953125}, {"start": 361.66, "end": 361.88, "word": " you", "probability": 0.9580078125}, {"start": 361.88, "end": 362.12, "word": " heard", "probability": 0.89306640625}, {"start": 362.12, "end": 362.3, "word": " in", "probability": 0.86572265625}, {"start": 362.3, "end": 362.46, "word": " the", "probability": 0.92431640625}, {"start": 362.46, "end": 362.92, "word": " interview.", "probability": 0.9560546875}], "temperature": 1.0}, {"id": 14, "seek": 39343, "start": 363.71, "end": 393.43, "text": " Can you identify which questions use falling intonation and which ones use rising intonation? Interview questions. One, what do you do? Two, how long have you been building flutes? Three, can I see one of your flutes? Four, is this your flute? Did I read all four questions with the same intonation pattern?", "tokens": [1664, 291, 5876, 597, 1651, 764, 7440, 560, 266, 399, 293, 597, 2306, 764, 11636, 560, 266, 399, 30, 35599, 1651, 13, 1485, 11, 437, 360, 291, 360, 30, 4453, 11, 577, 938, 362, 291, 668, 2390, 932, 1819, 30, 6244, 11, 393, 286, 536, 472, 295, 428, 932, 1819, 30, 7451, 11, 307, 341, 428, 33088, 30, 2589, 286, 1401, 439, 1451, 1651, 365, 264, 912, 560, 266, 399, 5102, 30], "avg_logprob": -0.07379067107422711, "compression_ratio": 1.6382978723404256, "no_speech_prob": 1.33514404296875e-05, "words": [{"start": 363.71, "end": 363.97, "word": " Can", "probability": 0.9169921875}, {"start": 363.97, "end": 364.15, "word": " you", "probability": 0.9677734375}, {"start": 364.15, "end": 364.73, "word": " identify", "probability": 0.9326171875}, {"start": 364.73, "end": 365.13, "word": " which", "probability": 0.9453125}, {"start": 365.13, "end": 365.71, "word": " questions", "probability": 0.91455078125}, {"start": 365.71, "end": 365.97, "word": " use", "probability": 0.81591796875}, {"start": 365.97, "end": 366.31, "word": " falling", "probability": 0.8515625}, {"start": 366.31, "end": 367.07, "word": " intonation", "probability": 0.9656575520833334}, {"start": 367.07, "end": 367.49, "word": " and", "probability": 0.78662109375}, {"start": 367.49, "end": 367.69, "word": " which", "probability": 0.947265625}, {"start": 367.69, "end": 367.97, "word": " ones", "probability": 0.88037109375}, {"start": 367.97, "end": 368.15, "word": " use", "probability": 0.8935546875}, {"start": 368.15, "end": 368.61, "word": " rising", "probability": 0.93115234375}, {"start": 368.61, "end": 369.31, "word": " intonation?", "probability": 0.9576822916666666}, {"start": 371.25, "end": 371.95, "word": " Interview", "probability": 0.9638671875}, {"start": 371.95, "end": 372.79, "word": " questions.", "probability": 0.88427734375}, {"start": 373.57, "end": 373.93, "word": " One,", "probability": 0.623046875}, {"start": 374.33, "end": 375.05, "word": " what", "probability": 0.7890625}, {"start": 375.05, "end": 375.23, "word": " do", "probability": 0.96240234375}, {"start": 375.23, "end": 375.35, "word": " you", "probability": 0.96630859375}, {"start": 375.35, "end": 375.67, "word": " do?", "probability": 0.9619140625}, {"start": 377.15, "end": 377.57, "word": " Two,", "probability": 0.88623046875}, {"start": 377.75, "end": 378.49, "word": " how", "probability": 0.91357421875}, {"start": 378.49, "end": 378.83, "word": " long", "probability": 0.92236328125}, {"start": 378.83, "end": 378.99, "word": " have", "probability": 0.943359375}, {"start": 378.99, "end": 379.07, "word": " you", "probability": 0.96240234375}, {"start": 379.07, "end": 379.25, "word": " been", "probability": 0.89111328125}, {"start": 379.25, "end": 379.53, "word": " building", "probability": 0.8876953125}, {"start": 379.53, "end": 379.95, "word": " flutes?", "probability": 0.97900390625}, {"start": 381.49, "end": 381.97, "word": " 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because most yes-no questions use rising intonation. Information questions, meaning questions that begin with what, who, why, where, when, how, etc. use falling intonation. If you need to, go back and listen to how I read those four questions. Now it's your turn to practice intonation patterns in questions. Listen and repeat. Number one.", "tokens": [883, 13, 400, 300, 311, 570, 881, 2086, 12, 1771, 1651, 764, 11636, 560, 266, 399, 13, 15357, 1651, 11, 3620, 1651, 300, 1841, 365, 437, 11, 567, 11, 983, 11, 689, 11, 562, 11, 577, 11, 5183, 13, 764, 7440, 560, 266, 399, 13, 759, 291, 643, 281, 11, 352, 646, 293, 2140, 281, 577, 286, 1401, 729, 1451, 1651, 13, 823, 309, 311, 428, 1261, 281, 3124, 560, 266, 399, 8294, 294, 1651, 13, 7501, 293, 7149, 13, 5118, 472, 13], "avg_logprob": -0.12295386665278957, "compression_ratio": 1.7401960784313726, "no_speech_prob": 5.7220458984375e-06, "words": [{"start": 395.01, "end": 395.41, "word": " No.", "probability": 0.81103515625}, {"start": 395.89, "end": 396.11, "word": " And", "probability": 0.9033203125}, {"start": 396.11, "end": 396.39, "word": " that's", "probability": 0.939453125}, {"start": 396.39, "end": 396.75, "word": " because", "probability": 0.9033203125}, {"start": 396.75, "end": 397.13, "word": " most", "probability": 0.89013671875}, {"start": 397.13, 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403.29, "end": 403.63, "word": " with", "probability": 0.90625}, {"start": 403.63, "end": 403.99, "word": " what,", "probability": 0.6796875}, {"start": 404.19, "end": 404.49, "word": " who,", "probability": 0.921875}, {"start": 404.65, "end": 404.97, "word": " why,", "probability": 0.94482421875}, {"start": 405.13, "end": 405.41, "word": " where,", "probability": 0.95068359375}, {"start": 405.67, "end": 405.97, "word": " when,", "probability": 0.93994140625}, {"start": 406.19, "end": 406.51, "word": " how,", "probability": 0.939453125}, {"start": 406.69, "end": 407.05, "word": " etc.", "probability": 0.78076171875}, {"start": 407.71, "end": 407.95, "word": " use", "probability": 0.80517578125}, {"start": 407.95, "end": 408.31, "word": " falling", "probability": 0.8291015625}, {"start": 408.31, "end": 409.03, "word": " intonation.", "probability": 0.94970703125}, {"start": 409.71, "end": 410.35, "word": " If", "probability": 0.96435546875}, {"start": 410.35, "end": 410.51, "word": " you", "probability": 0.9658203125}, {"start": 410.51, "end": 410.73, "word": " need", "probability": 0.92724609375}, {"start": 410.73, "end": 410.97, "word": " to,", "probability": 0.97021484375}, {"start": 411.13, "end": 411.37, "word": " go", "probability": 0.96533203125}, {"start": 411.37, "end": 411.83, "word": " back", "probability": 0.869140625}, {"start": 411.83, "end": 412.23, "word": " and", "probability": 0.888671875}, {"start": 412.23, "end": 412.49, "word": " listen", "probability": 0.8857421875}, {"start": 412.49, "end": 412.71, "word": " to", "probability": 0.9658203125}, {"start": 412.71, "end": 412.95, "word": " how", "probability": 0.93896484375}, {"start": 412.95, "end": 413.09, "word": " I", "probability": 0.99755859375}, {"start": 413.09, "end": 413.25, "word": " read", "probability": 0.92919921875}, {"start": 413.25, "end": 413.49, "word": " those", "probability": 0.73779296875}, {"start": 413.49, "end": 413.69, "word": " four", "probability": 0.83984375}, 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Two. How long have you been building flutes? Three. How long does it take you to make a flute? Four. Can I see one of your flutes? Five. Is this your flute? Six. Can you play the flute? 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Eight. Do you play any other instruments? Nine. How did you learn to play all these instruments? Exercise six. Read the question. Decide if falling or rising intonation is needed. 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The priority questions, when, why, where, how, are also ending with foreign information. The answer questions are all high information. 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Who prepared the lesson? Okay. This is two, three, one. Because this is a huge question. Okay. Did you attend the class? Did you attend the class? The class is three, three. High pitch, high pitch. Okay. The two question. 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Okay? Or rise, rise. Okay? So, here we have in our lesson, we have only two types spoken about. The declarative and WH questions are of two, three, one. The yes, no questions, the two questions are two,", "tokens": [440, 11636, 11, 6272, 11, 2100, 13, 1033, 30, 1610, 6272, 11, 6272, 13, 1033, 30, 407, 11, 510, 321, 362, 294, 527, 6898, 11, 321, 362, 787, 732, 3467, 10759, 466, 13, 440, 16694, 1166, 293, 8183, 1651, 366, 295, 732, 11, 1045, 11, 472, 13, 440, 2086, 11, 572, 1651, 11, 264, 732, 1651, 366, 732, 11], "avg_logprob": -0.21210938170552254, "compression_ratio": 1.5337837837837838, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 637.3, "end": 637.56, "word": " The", "probability": 0.453369140625}, {"start": 637.56, "end": 638.06, "word": " rising,", "probability": 0.841796875}, {"start": 638.4, "end": 638.84, "word": " rise,", "probability": 0.91796875}, {"start": 639.06, "end": 639.24, "word": " fall.", "probability": 0.8818359375}, {"start": 641.32, "end": 641.62, "word": " Okay?", "probability": 0.59521484375}, {"start": 641.98, "end": 642.52, "word": " Or", "probability": 0.9716796875}, {"start": 642.52, "end": 643.48, "word": " rise,", "probability": 0.83544921875}, {"start": 643.86, "end": 644.36, "word": " rise.", "probability": 0.919921875}, {"start": 645.8, "end": 646.26, "word": " Okay?", "probability": 0.81787109375}, {"start": 646.82, "end": 647.2, "word": " So,", "probability": 0.95703125}, {"start": 647.72, "end": 648.2, "word": " here", "probability": 0.86376953125}, {"start": 648.2, "end": 648.38, "word": " we", "probability": 0.9052734375}, {"start": 648.38, "end": 648.72, "word": " have", "probability": 0.94677734375}, {"start": 648.72, "end": 648.96, "word": " in", "probability": 0.7392578125}, {"start": 648.96, "end": 649.22, "word": " our", "probability": 0.89111328125}, {"start": 649.22, "end": 649.6, "word": " lesson,", "probability": 0.91748046875}, {"start": 650.22, "end": 650.44, "word": " we", "probability": 0.95556640625}, {"start": 650.44, "end": 650.7, "word": " have", "probability": 0.9443359375}, {"start": 650.7, "end": 651.06, "word": " only", "probability": 0.923828125}, {"start": 651.06, "end": 651.3, "word": " two", "probability": 0.93798828125}, {"start": 651.3, "end": 651.72, "word": " types", "probability": 0.8544921875}, {"start": 651.72, "end": 652.26, "word": " spoken", "probability": 0.96044921875}, {"start": 652.26, "end": 652.74, "word": " about.", "probability": 0.90478515625}, {"start": 653.82, "end": 654.14, "word": " The", "probability": 0.89111328125}, {"start": 654.14, "end": 654.74, "word": " declarative", "probability": 0.897705078125}, {"start": 654.74, "end": 655.02, "word": " and", "probability": 0.9365234375}, {"start": 655.02, "end": 655.36, "word": " WH", "probability": 0.4658203125}, {"start": 655.36, "end": 656.04, "word": " questions", "probability": 0.94580078125}, {"start": 656.04, "end": 657.0, "word": " are", "probability": 0.93798828125}, {"start": 657.0, "end": 657.58, "word": " of", "probability": 0.96142578125}, {"start": 657.58, "end": 658.44, "word": " two,", "probability": 0.619140625}, {"start": 658.64, "end": 658.8, "word": " three,", "probability": 0.9326171875}, {"start": 658.92, "end": 659.16, "word": " one.", "probability": 0.93994140625}, {"start": 659.8, "end": 660.22, "word": " The", "probability": 0.86962890625}, {"start": 660.22, "end": 660.64, "word": " yes,", "probability": 0.83837890625}, {"start": 660.72, "end": 660.8, "word": " no", "probability": 0.96240234375}, {"start": 660.8, "end": 661.48, "word": " questions,", "probability": 0.94140625}, {"start": 662.22, "end": 662.34, "word": " the", "probability": 0.92724609375}, {"start": 662.34, "end": 662.52, "word": " two", "probability": 0.646484375}, {"start": 662.52, "end": 663.04, "word": " questions", "probability": 0.8662109375}, {"start": 663.04, "end": 663.46, "word": " are", "probability": 0.71337890625}, {"start": 663.46, "end": 663.86, "word": " two,", "probability": 0.82568359375}], "temperature": 1.0}, {"id": 24, "seek": 69180, "start": 664.38, "end": 691.8, "text": " We need to notice this and try to follow up with the class about intonation recorded here. 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Listening task. Listen to a few of the questions you heard in the interview. Can you identify which questions use following it? Topic, intonation. Part four. Do you play an instrument? 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Study tip. Do you have a study partner? If so, take turns asking the questions. Let's begin. Question one. Again, I'll pause to give you a chance to read the question on your own. What kind of music do you like? You could repeat it, please. 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"seek": 84334, "start": 815.06, "end": 843.34, "text": " Music is three, three, okay? Can you read music? This is three, three. Can you read music? Can you read music? You is three, then one, okay? This is called emphatic pitch, okay? Emphatic pitch. You focus on the word you need to emphasize on. Can you read music? 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Have you ever been to the opera? The focus is on the opera, okay? Have you ever been to the opera? Opera, okay? Have you ever been to the opera? Have you? Okay, so the stress is on you. 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We have the grammatical function, as I mentioned. They distinguish between the statement sentence and the question, the imperative, etc. Also, it reflects the speaker's attitude. So, you express by intonation your surprise, your admiration, your excitement. Okay? So, it refers to... 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Your feeling can be translated on the intonation system. Okay? Also, emphasis is translated by the intonation system. The high pitch on whatever word you need to stress on.", "tokens": [467, 39204, 11, 382, 291, 536, 11, 6365, 11, 25687, 30273, 11, 44597, 13, 2260, 2633, 393, 312, 16805, 322, 264, 560, 266, 399, 1185, 13, 1033, 30, 2743, 11, 16271, 307, 16805, 538, 264, 560, 266, 399, 1185, 13, 440, 1090, 7293, 322, 2035, 1349, 291, 643, 281, 4244, 322, 13], "avg_logprob": -0.14305719452084237, "compression_ratio": 1.4873417721518987, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 907.1, "end": 907.4, "word": " It", "probability": 0.6435546875}, {"start": 907.4, "end": 907.78, "word": " expresses,", "probability": 0.5693359375}, {"start": 908.2, "end": 908.7, "word": " as", "probability": 0.96728515625}, {"start": 908.7, "end": 908.84, "word": " you", "probability": 0.96826171875}, {"start": 908.84, "end": 909.12, "word": " see,", "probability": 0.90966796875}, {"start": 909.4, "end": 909.82, "word": " surprise,", "probability": 0.89599609375}, {"start": 910.7, "end": 911.46, "word": " astonishment,", "probability": 0.944580078125}, {"start": 912.04, "end": 912.66, "word": " admiration.", "probability": 0.96240234375}, {"start": 913.12, "end": 913.38, "word": " Your", "probability": 0.8896484375}, {"start": 913.38, "end": 913.76, "word": " feeling", "probability": 0.51318359375}, {"start": 913.76, "end": 914.04, "word": " can", "probability": 0.91796875}, {"start": 914.04, "end": 914.2, "word": " be", "probability": 0.9599609375}, {"start": 914.2, "end": 914.82, "word": " translated", "probability": 0.80029296875}, {"start": 914.82, "end": 915.8, "word": " on", "probability": 0.7646484375}, {"start": 915.8, "end": 916.2, "word": " the", "probability": 0.92041015625}, {"start": 916.2, "end": 916.68, "word": " intonation", "probability": 0.9768880208333334}, {"start": 916.68, "end": 917.2, "word": " system.", "probability": 0.94775390625}, {"start": 918.16, "end": 918.3, "word": " Okay?", "probability": 0.56591796875}, {"start": 919.3, "end": 919.72, "word": " Also,", "probability": 0.9482421875}, {"start": 919.86, "end": 920.24, "word": " emphasis", "probability": 0.8349609375}, {"start": 920.24, "end": 921.76, "word": " is", "probability": 0.93701171875}, {"start": 921.76, "end": 922.3, "word": " translated", "probability": 0.81005859375}, {"start": 922.3, "end": 922.8, "word": " by", "probability": 0.96923828125}, {"start": 922.8, "end": 923.16, "word": " the", "probability": 0.921875}, {"start": 923.16, "end": 923.64, "word": " intonation", "probability": 0.9609375}, {"start": 923.64, "end": 924.16, "word": " system.", "probability": 0.951171875}, {"start": 924.62, "end": 924.76, "word": " The", "probability": 0.88623046875}, {"start": 924.76, "end": 925.04, "word": " high", "probability": 0.92822265625}, {"start": 925.04, "end": 925.42, "word": " pitch", "probability": 0.86962890625}, {"start": 925.42, "end": 926.2, "word": " on", "probability": 0.845703125}, {"start": 926.2, "end": 926.64, "word": " whatever", "probability": 0.9365234375}, {"start": 926.64, "end": 927.22, "word": " word", "probability": 0.93896484375}, {"start": 927.22, "end": 927.78, "word": " you", "probability": 0.96240234375}, {"start": 927.78, "end": 928.08, "word": " need", "probability": 0.93359375}, {"start": 928.08, "end": 928.34, "word": " to", "probability": 0.966796875}, {"start": 928.34, "end": 928.74, "word": " stress", "probability": 0.9501953125}, {"start": 928.74, "end": 929.08, "word": " on.", "probability": 0.93359375}], "temperature": 1.0}, {"id": 33, "seek": 96649, "start": 937.91, "end": 966.49, "text": " Question four. How often do you listen to live music? Okay. Question four. Who could read it for me? Salha. How often do you like... How often do you listen to live music? How often do you listen to live music?", "tokens": [14464, 1451, 13, 1012, 2049, 360, 291, 2140, 281, 1621, 1318, 30, 1033, 13, 14464, 1451, 13, 2102, 727, 1401, 309, 337, 385, 30, 5996, 1641, 13, 1012, 2049, 360, 291, 411, 485, 1012, 2049, 360, 291, 2140, 281, 1621, 1318, 30, 1012, 2049, 360, 291, 2140, 281, 1621, 1318, 30], "avg_logprob": -0.18765024153085855, "compression_ratio": 2.0686274509803924, "no_speech_prob": 4.76837158203125e-07, "words": [{"start": 937.91, "end": 938.45, "word": " Question", "probability": 0.669921875}, {"start": 938.45, "end": 938.93, "word": " four.", "probability": 0.5849609375}, {"start": 941.91, "end": 942.47, "word": " How", "probability": 0.89453125}, {"start": 942.47, "end": 942.79, "word": " often", "probability": 0.79638671875}, {"start": 942.79, "end": 943.01, "word": " do", "probability": 0.95166015625}, {"start": 943.01, "end": 943.13, "word": " you", "probability": 0.96484375}, {"start": 943.13, "end": 943.41, "word": " listen", "probability": 0.91357421875}, {"start": 943.41, "end": 943.61, "word": " to", "probability": 0.97314453125}, {"start": 943.61, "end": 943.89, "word": " live", "probability": 0.93359375}, {"start": 943.89, "end": 944.35, "word": " music?", "probability": 0.9326171875}, {"start": 949.37, "end": 949.93, "word": " Okay.", "probability": 0.63037109375}, {"start": 950.45, "end": 950.93, "word": " Question", "probability": 0.775390625}, {"start": 950.93, "end": 951.37, "word": " four.", "probability": 0.9345703125}, {"start": 951.47, "end": 951.57, "word": " Who", "probability": 0.87939453125}, {"start": 951.57, "end": 951.69, "word": " could", "probability": 0.79443359375}, {"start": 951.69, "end": 951.91, "word": " read", "probability": 0.97607421875}, {"start": 951.91, "end": 952.05, "word": " it", "probability": 0.94287109375}, {"start": 952.05, "end": 952.23, "word": " for", "probability": 0.947265625}, {"start": 952.23, "end": 952.47, "word": " me?", "probability": 0.96533203125}, {"start": 954.13, "end": 954.53, "word": " Salha.", "probability": 0.471923828125}, {"start": 955.87, "end": 956.23, "word": " How", "probability": 0.9072265625}, {"start": 956.23, "end": 956.45, "word": " often", "probability": 0.80126953125}, {"start": 956.45, "end": 956.63, "word": " do", "probability": 0.94970703125}, {"start": 956.63, "end": 956.77, "word": " you", "probability": 0.97021484375}, {"start": 956.77, "end": 959.51, "word": " like...", "probability": 0.484130859375}, {"start": 959.51, "end": 960.15, "word": " How", "probability": 0.810546875}, {"start": 960.15, "end": 960.41, "word": " often", "probability": 0.80712890625}, {"start": 960.41, "end": 960.59, "word": " do", "probability": 0.9560546875}, {"start": 960.59, "end": 960.75, "word": " you", "probability": 0.9638671875}, {"start": 960.75, "end": 961.15, "word": " listen", "probability": 0.927734375}, {"start": 961.15, "end": 961.61, "word": " to", "probability": 0.97216796875}, {"start": 961.61, "end": 962.23, "word": " live", "probability": 0.9443359375}, {"start": 962.23, "end": 962.75, "word": " music?", "probability": 0.9296875}, {"start": 963.03, "end": 963.53, "word": " How", "probability": 0.9609375}, {"start": 963.53, "end": 963.81, "word": " often", "probability": 0.81640625}, {"start": 963.81, "end": 963.95, "word": " do", "probability": 0.95654296875}, {"start": 963.95, "end": 964.09, "word": " you", "probability": 0.96337890625}, {"start": 964.09, "end": 964.35, "word": " listen", "probability": 0.921875}, {"start": 964.35, "end": 964.55, "word": " to", "probability": 0.97216796875}, {"start": 964.55, "end": 966.07, "word": " live", "probability": 0.65283203125}, {"start": 966.07, "end": 966.49, "word": " music?", "probability": 0.92626953125}], "temperature": 1.0}, {"id": 34, "seek": 99233, "start": 966.95, "end": 992.33, "text": " How often do you listen to live music? Live music is of high, fall. High, fall. Okay? Every chance I get. Every chance I get. Okay? Get is three, one. It is two, you start with medium, then high, then fall. Okay?", "tokens": [1012, 2049, 360, 291, 2140, 281, 1621, 1318, 30, 10385, 1318, 307, 295, 1090, 11, 2100, 13, 5229, 11, 2100, 13, 1033, 30, 2048, 2931, 286, 483, 13, 2048, 2931, 286, 483, 13, 1033, 30, 3240, 307, 1045, 11, 472, 13, 467, 307, 732, 11, 291, 722, 365, 6399, 11, 550, 1090, 11, 550, 2100, 13, 1033, 30], "avg_logprob": -0.17849575867087153, "compression_ratio": 1.5661764705882353, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 966.95, "end": 967.17, "word": " How", "probability": 0.8955078125}, {"start": 967.17, "end": 967.45, "word": " often", "probability": 0.818359375}, {"start": 967.45, "end": 967.61, "word": " do", "probability": 0.94189453125}, {"start": 967.61, "end": 967.71, "word": " you", "probability": 0.96435546875}, {"start": 967.71, "end": 967.99, "word": " listen", "probability": 0.9228515625}, {"start": 967.99, "end": 968.19, "word": " to", "probability": 0.9755859375}, {"start": 968.19, "end": 968.79, "word": " live", "probability": 0.9462890625}, {"start": 968.79, "end": 969.25, "word": " music?", "probability": 0.91455078125}, {"start": 970.05, "end": 970.35, "word": " Live", "probability": 0.95068359375}, {"start": 970.35, "end": 970.89, "word": " music", "probability": 0.92724609375}, {"start": 970.89, "end": 972.29, "word": " is", "probability": 0.947265625}, {"start": 972.29, "end": 972.77, "word": " of", "probability": 0.9619140625}, {"start": 972.77, "end": 973.89, "word": " high,", "probability": 0.890625}, {"start": 974.11, "end": 974.37, "word": " fall.", "probability": 0.295654296875}, {"start": 975.25, "end": 975.75, "word": " High,", "probability": 0.89208984375}, {"start": 975.89, "end": 976.17, "word": " fall.", "probability": 0.86376953125}, {"start": 976.87, "end": 977.23, "word": " Okay?", "probability": 0.83349609375}, {"start": 978.81, "end": 979.45, "word": " Every", "probability": 0.83740234375}, {"start": 979.45, "end": 979.83, "word": " chance", "probability": 0.97607421875}, {"start": 979.83, "end": 980.05, "word": " I", "probability": 0.97705078125}, {"start": 980.05, "end": 980.31, "word": " get.", "probability": 0.95263671875}, {"start": 981.27, "end": 981.91, "word": " Every", "probability": 0.8330078125}, {"start": 981.91, "end": 982.29, "word": " chance", "probability": 0.97705078125}, {"start": 982.29, "end": 982.51, "word": " I", "probability": 0.998046875}, {"start": 982.51, "end": 982.73, "word": " get.", "probability": 0.9501953125}, {"start": 983.87, "end": 984.19, "word": " Okay?", "probability": 0.828125}, {"start": 984.69, "end": 985.01, "word": " Get", "probability": 0.89306640625}, {"start": 985.01, "end": 985.21, "word": " is", "probability": 0.9287109375}, {"start": 985.21, "end": 985.49, "word": " three,", "probability": 0.56201171875}, {"start": 985.59, "end": 985.81, "word": " one.", "probability": 0.94384765625}, {"start": 986.49, "end": 986.69, "word": " It", "probability": 0.4677734375}, {"start": 986.69, "end": 987.05, "word": " is", "probability": 0.7802734375}, {"start": 987.05, "end": 987.33, "word": " two,", "probability": 0.90185546875}, {"start": 987.49, "end": 987.61, "word": " you", "probability": 0.93603515625}, {"start": 987.61, "end": 987.99, "word": " start", "probability": 0.9326171875}, {"start": 987.99, "end": 988.21, "word": " with", "probability": 0.888671875}, {"start": 988.21, "end": 988.63, "word": " medium,", "probability": 0.62939453125}, {"start": 989.23, "end": 989.53, "word": " then", "probability": 0.85009765625}, {"start": 989.53, "end": 990.23, "word": " high,", "probability": 0.89404296875}, {"start": 990.41, "end": 990.73, "word": " then", "probability": 0.8525390625}, {"start": 990.73, "end": 991.57, "word": " fall.", "probability": 0.83544921875}, {"start": 991.93, "end": 992.33, "word": " Okay?", "probability": 0.8701171875}], "temperature": 1.0}, {"id": 35, "seek": 102519, "start": 995.61, "end": 1025.19, "text": " Not as often as I'd like. Okay? Not as often as I'd like. So, it is again two, three, one. The three one is on the verb like. Yes. Sir, the high and fall in live music, is it on something? No, no, just the high and fall is on music itself, live music. Okay? Yes. The last word, it is the topic one.", "tokens": [1726, 382, 2049, 382, 286, 1116, 411, 13, 1033, 30, 1726, 382, 2049, 382, 286, 1116, 411, 13, 407, 11, 309, 307, 797, 732, 11, 1045, 11, 472, 13, 440, 1045, 472, 307, 322, 264, 9595, 411, 13, 1079, 13, 6144, 11, 264, 1090, 293, 2100, 294, 1621, 1318, 11, 307, 309, 322, 746, 30, 883, 11, 572, 11, 445, 264, 1090, 293, 2100, 307, 322, 1318, 2564, 11, 1621, 1318, 13, 1033, 30, 1079, 13, 440, 1036, 1349, 11, 309, 307, 264, 4829, 472, 13], "avg_logprob": -0.2537715585752465, "compression_ratio": 1.7283236994219653, "no_speech_prob": 0.0, "words": [{"start": 995.61, "end": 995.87, "word": " Not", "probability": 0.658203125}, {"start": 995.87, "end": 996.11, "word": " as", "probability": 0.96435546875}, {"start": 996.11, "end": 996.37, "word": " often", "probability": 0.78857421875}, {"start": 996.37, "end": 996.61, "word": " as", "probability": 0.966796875}, {"start": 996.61, "end": 996.83, "word": " I'd", "probability": 0.939697265625}, 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So it is true. How often do you listen to live music? Live music, you raise your voice, then you fall, you have a falling intonation. At this point, I'd like to share some helpful tips for more natural intonation. 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So for good falling intonation, your voice needs to come down from a higher note. Also, go down a little before a rise. So for good rising intonation, your voice needs to come up from a lower note. Finally, start a statement at mid-pitch. Don't start too high or low. Let me demonstrate all of this through an example.", "tokens": [1037, 493, 257, 707, 949, 257, 2100, 13, 407, 337, 665, 7440, 560, 266, 399, 11, 428, 3177, 2203, 281, 808, 760, 490, 257, 2946, 3637, 13, 2743, 11, 352, 760, 257, 707, 949, 257, 6272, 13, 407, 337, 665, 11636, 560, 266, 399, 11, 428, 3177, 2203, 281, 808, 493, 490, 257, 3126, 3637, 13, 6288, 11, 722, 257, 5629, 412, 2062, 12, 79, 1549, 13, 1468, 380, 722, 886, 1090, 420, 2295, 13, 961, 385, 11698, 439, 295, 341, 807, 364, 1365, 13], "avg_logprob": -0.08879905523255814, "compression_ratio": 1.7715736040609138, "no_speech_prob": 1.5735626220703125e-05, "words": [{"start": 1055.9, "end": 1056.22, "word": " Go", "probability": 0.79248046875}, {"start": 1056.22, "end": 1056.44, "word": " up", "probability": 0.97216796875}, {"start": 1056.44, "end": 1056.6, "word": " a", "probability": 0.99462890625}, {"start": 1056.6, "end": 1056.8, "word": " little", "probability": 0.85498046875}, {"start": 1056.8, "end": 1057.2, "word": " 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Eric is the only musician among them. Are there any musicians in your neighborhood? The first sentence can be read as one thought group. Let's mark that. We're giving factual information, making a statement. So we use following intonation. Our final content word is neighbors. 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So we'll rise on the stressed syllable and then step down to a lower pitch. Neighbors. Now in this sentence, we can't start too low or else you won't hear the following intonation. If I start too low, it sounds like this. 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And if I start too high, it sounds unnatural. I'm with several of my neighbors. So you see that we actually have to begin our sentence at a mid-pitch. I'm with several of my neighbors. Understand? 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Now, at the end of our example, we have a question. Okay. We're asking a yes or no question, so we'll use rising intonation. And what is the final content word? It's neighborhood. But is that the word that receives primary stress? 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Exercise seven. Listen closely to the statement. What does the intonation tell you? Examples. One. This is jazz. Following intonation tells you the speaker is certain. Now listen to example two. 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Is he certain or uncertain? Uncertain. Because this is question. So, this is jazz. This is called tune question. So, it must be two, three, three. Okay? Two, mid, high, high. This is jazz. 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Number one, Alice Fitzgerald was a singer? Yes. This is a question. It is tune question. Is it certain or uncertain? Uncertain. Uncertain. So, the last word singer must be three, three. 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John Williams composes music, so it is certain. It must be two, three, one. Two, three, one. Three, I like soft rock, folk music, jazz, classical. 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This is certain, okay? The last item is pronounced with rise-fall intonation because this is called listing. Four. Turn up the radio. I like the song. Turn on the radio. 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Okay? Turn on the radio. This is two, three, one. Okay? I like the song. Now we have turn on the radio, I like the song. So this means that you have to pronounce it in two, three, two, three, one. 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I like this music. Okay? Turn on the radio. I like this music. Okay? Exercise eight. Listening task. 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Do you perform? I do. I perform on flute mostly these days. Who do you perform for or who do you perform with? I play with a group. What did you see? This means that you need him to repeat. Okay? 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1554.42, "text": " 3, 1. 3, 1 at C. Okay? Also for making... I say, once you need to ask about a question, you need some explanation, more explanation. I studied in London. I studied my PhD in London. You say, London?", "tokens": [805, 11, 502, 13, 805, 11, 502, 412, 383, 13, 1033, 30, 2743, 337, 1455, 485, 286, 584, 11, 1564, 291, 643, 281, 1029, 466, 257, 1168, 11, 291, 643, 512, 10835, 11, 544, 10835, 13, 286, 9454, 294, 7042, 13, 286, 9454, 452, 14476, 294, 7042, 13, 509, 584, 11, 7042, 30], "avg_logprob": -0.17259837797394506, "compression_ratio": 1.474074074074074, "no_speech_prob": 0.0, "words": [{"start": 1526.9599999999998, "end": 1527.62, "word": " 3,", "probability": 0.43408203125}, {"start": 1527.62, "end": 1528.28, "word": " 1.", "probability": 0.7626953125}, {"start": 1528.68, "end": 1529.18, "word": " 3,", "probability": 0.9609375}, {"start": 1529.26, "end": 1529.48, "word": " 1", "probability": 0.9462890625}, {"start": 1529.48, "end": 1529.96, "word": " at", "probability": 0.7861328125}, {"start": 1529.96, "end": 1530.86, "word": " C.", "probability": 0.85693359375}, {"start": 1532.0, "end": 1532.34, "word": " Okay?", "probability": 0.53759765625}, {"start": 1538.12, "end": 1538.78, "word": " Also", "probability": 0.94091796875}, {"start": 1538.78, "end": 1539.08, "word": " for", "probability": 0.669921875}, {"start": 1539.08, "end": 1541.46, "word": " making...", "probability": 0.6279296875}, {"start": 1541.46, "end": 1541.76, "word": " I", "probability": 0.8388671875}, {"start": 1541.76, "end": 1541.98, "word": " say,", "probability": 0.8935546875}, {"start": 1543.22, "end": 1544.16, "word": " once", "probability": 0.79833984375}, {"start": 1544.16, "end": 1544.34, "word": " you", "probability": 0.96240234375}, {"start": 1544.34, "end": 1544.52, "word": " need", "probability": 0.89013671875}, {"start": 1544.52, "end": 1544.64, "word": " to", "probability": 0.966796875}, {"start": 1544.64, "end": 1544.88, "word": " ask", "probability": 0.93603515625}, {"start": 1544.88, "end": 1545.16, "word": " about", "probability": 0.76123046875}, {"start": 1545.16, "end": 1545.68, "word": " a", "probability": 0.95361328125}, {"start": 1545.68, "end": 1545.98, "word": " question,", "probability": 0.9267578125}, {"start": 1546.12, "end": 1546.2, "word": " you", "probability": 0.96044921875}, {"start": 1546.2, "end": 1546.42, "word": " need", "probability": 0.9267578125}, {"start": 1546.42, "end": 1546.72, "word": " some", "probability": 0.8369140625}, {"start": 1546.72, "end": 1547.36, "word": " explanation,", "probability": 0.8759765625}, {"start": 1547.52, "end": 1547.72, "word": " more", "probability": 0.93603515625}, {"start": 1547.72, "end": 1548.32, "word": " explanation.", "probability": 0.8955078125}, {"start": 1548.82, "end": 1549.34, "word": " I", "probability": 0.71142578125}, {"start": 1549.34, "end": 1549.74, "word": " studied", "probability": 0.9345703125}, {"start": 1549.74, "end": 1549.98, "word": " in", "probability": 0.955078125}, {"start": 1549.98, "end": 1550.26, "word": " London.", "probability": 0.84814453125}, {"start": 1550.88, "end": 1551.54, "word": " I", "probability": 0.99560546875}, {"start": 1551.54, "end": 1551.92, "word": " studied", "probability": 0.95458984375}, {"start": 1551.92, "end": 1552.24, "word": " my", "probability": 0.970703125}, {"start": 1552.24, "end": 1552.62, "word": " PhD", "probability": 0.837890625}, {"start": 1552.62, "end": 1553.04, "word": " in", "probability": 0.95361328125}, {"start": 1553.04, "end": 1553.32, "word": " London.", "probability": 0.84619140625}, {"start": 1553.42, "end": 1553.54, "word": " You", "probability": 0.96337890625}, {"start": 1553.54, "end": 1553.82, "word": " say,", "probability": 0.94287109375}, {"start": 1554.18, "end": 1554.42, "word": " London?", "probability": 0.1280517578125}], "temperature": 1.0}, {"id": 54, "seek": 158073, "start": 1555.23, "end": 1580.73, "text": " London, this means that you don't know about London and you need more explanation, okay? Yesterday, our teacher explained the geography of Papua New Guinea. Papua New Guinea, this means that you don't understand anything about this state, so you need more explanation, okay?", "tokens": [7042, 11, 341, 1355, 300, 291, 500, 380, 458, 466, 7042, 293, 291, 643, 544, 10835, 11, 1392, 30, 19765, 11, 527, 5027, 8825, 264, 26695, 295, 15919, 4398, 1873, 46793, 13, 15919, 4398, 1873, 46793, 11, 341, 1355, 300, 291, 500, 380, 1223, 1340, 466, 341, 1785, 11, 370, 291, 643, 544, 10835, 11, 1392, 30], "avg_logprob": -0.16931573121712126, "compression_ratio": 1.7973856209150327, "no_speech_prob": 0.0, "words": [{"start": 1555.23, "end": 1555.85, "word": " London,", "probability": 0.75732421875}, {"start": 1556.23, "end": 1556.41, "word": " this", "probability": 0.91748046875}, {"start": 1556.41, "end": 1556.71, "word": " means", "probability": 0.93115234375}, {"start": 1556.71, "end": 1557.03, "word": " that", "probability": 0.8603515625}, {"start": 1557.03, "end": 1557.17, "word": " you", "probability": 0.9609375}, {"start": 1557.17, "end": 1557.35, "word": " don't", "probability": 0.959228515625}, {"start": 1557.35, "end": 1557.55, "word": " know", "probability": 0.89404296875}, {"start": 1557.55, "end": 1557.89, "word": " about", "probability": 0.90478515625}, {"start": 1557.89, "end": 1558.25, "word": " London", "probability": 0.8408203125}, {"start": 1558.25, "end": 1559.09, "word": " and", "probability": 0.73486328125}, {"start": 1559.09, "end": 1559.21, "word": " you", "probability": 0.96044921875}, {"start": 1559.21, "end": 1559.47, "word": " need", "probability": 0.9296875}, {"start": 1559.47, "end": 1559.95, "word": " more", "probability": 0.93359375}, {"start": 1559.95, "end": 1560.69, "word": " explanation,", "probability": 0.88818359375}, {"start": 1561.39, "end": 1561.69, "word": " okay?", "probability": 0.72998046875}, {"start": 1563.43, "end": 1564.19, "word": " Yesterday,", "probability": 0.81201171875}, {"start": 1564.75, "end": 1565.13, "word": " our", "probability": 0.89453125}, {"start": 1565.13, "end": 1565.59, "word": " teacher", "probability": 0.9609375}, {"start": 1565.59, "end": 1566.45, "word": " explained", "probability": 0.791015625}, {"start": 1566.45, "end": 1567.37, "word": " the", "probability": 0.91552734375}, {"start": 1567.37, "end": 1568.61, "word": " geography", "probability": 0.81005859375}, {"start": 1568.61, "end": 1570.03, "word": " of", "probability": 0.97216796875}, {"start": 1570.03, "end": 1570.47, "word": " Papua", "probability": 0.7042236328125}, {"start": 1570.47, "end": 1570.63, "word": " New", "probability": 0.869140625}, {"start": 1570.63, "end": 1570.97, "word": " Guinea.", "probability": 0.89013671875}, {"start": 1572.17, "end": 1572.55, "word": " Papua", "probability": 0.965576171875}, {"start": 1572.55, "end": 1572.71, "word": " New", "probability": 0.90771484375}, {"start": 1572.71, "end": 1572.99, "word": " Guinea,", "probability": 0.92138671875}, {"start": 1573.55, "end": 1574.37, "word": " this", "probability": 0.93603515625}, {"start": 1574.37, "end": 1574.63, "word": " means", "probability": 0.935546875}, {"start": 1574.63, "end": 1574.85, "word": " that", "probability": 0.91796875}, {"start": 1574.85, "end": 1574.95, "word": " you", "probability": 0.96337890625}, {"start": 1574.95, "end": 1575.13, "word": " don't", "probability": 0.97802734375}, {"start": 1575.13, "end": 1575.69, "word": " understand", "probability": 0.8056640625}, {"start": 1575.69, "end": 1576.07, "word": " anything", "probability": 0.87158203125}, {"start": 1576.07, "end": 1576.43, "word": " about", "probability": 0.90185546875}, {"start": 1576.43, "end": 1576.69, "word": " this", "probability": 0.94384765625}, {"start": 1576.69, "end": 1577.17, "word": " state,", "probability": 0.943359375}, {"start": 1577.59, "end": 1577.73, "word": " so", "probability": 0.947265625}, {"start": 1577.73, "end": 1577.91, "word": " you", "probability": 0.88330078125}, {"start": 1577.91, "end": 1578.15, "word": " need", "probability": 0.92529296875}, {"start": 1578.15, "end": 1578.65, "word": " more", "probability": 0.9306640625}, {"start": 1578.65, "end": 1579.67, "word": " explanation,", "probability": 0.908203125}, {"start": 1580.43, "end": 1580.73, "word": " okay?", "probability": 0.9091796875}], "temperature": 1.0}, {"id": 55, "seek": 161351, "start": 1585.25, "end": 1613.51, "text": " Once you express agreement, this is an intact question. You know him, do you? You know him, do you? When I say high rise, this means that it is two, three, three. You know him, do you? So, do you is two, you, three, three. You know him, do you? 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The low fall intonation, where the voice starts at a medium pitch and falls to the low pitch. This is to express cold and reserved speech. 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Who? Who? This is reserved reaction. Okay. Who? Okay. I went yesterday for making shopping with my daughter and bought here a very nice Islamic uniform. You say good. 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Okay? Good. Okay? So, this is called reserved speech pronounced in the lawful intonation. 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1706.13, "word": " for", "probability": 0.94091796875}, {"start": 1706.13, "end": 1706.67, "word": " about", "probability": 0.90087890625}, {"start": 1706.67, "end": 1707.11, "word": " ten", "probability": 0.52294921875}, {"start": 1707.11, "end": 1707.41, "word": " minutes", "probability": 0.921875}, {"start": 1707.41, "end": 1707.69, "word": " until", "probability": 0.8349609375}, {"start": 1707.69, "end": 1708.29, "word": " reaching", "probability": 0.87451171875}, {"start": 1708.29, "end": 1708.91, "word": " the", "probability": 0.91748046875}, {"start": 1708.91, "end": 1709.19, "word": " first", "probability": 0.87841796875}, {"start": 1709.19, "end": 1709.55, "word": " traffic", "probability": 0.89404296875}, {"start": 1709.55, "end": 1709.93, "word": " light,", "probability": 0.8955078125}, {"start": 1710.37, "end": 1710.81, "word": " then", "probability": 0.8525390625}, {"start": 1710.81, "end": 1711.73, "word": " turn", "probability": 0.79052734375}, {"start": 1711.73, "end": 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\ No newline at end of file
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@@ -0,0 +1,1452 @@
+1
+00:00:13,440 --> 00:00:17,760
+Today Inshallah, we are going to see a new chapter
+
+2
+00:00:17,760 --> 00:00:23,760
+that is Morphology word word formation How to
+
+3
+00:00:23,760 --> 00:00:28,060
+formulate words in English and Arabic as well Okay
+
+4
+00:00:34,558 --> 00:00:38,680
+So, there are in English several ways of
+
+5
+00:00:38,680 --> 00:00:39,880
+formulating words.
+
+6
+00:00:43,300 --> 00:00:49,080
+This is by the use of bound morphemes, either
+
+7
+00:00:49,080 --> 00:00:55,300
+suffixes or prefixes. Also, we have what is called
+
+8
+00:00:55,300 --> 00:01:00,420
+infixes these all together are called affixes
+
+9
+00:01:00,420 --> 00:01:06,360
+Okay, so in English in Arabic in all languages We
+
+10
+00:01:06,360 --> 00:01:10,500
+have morphemes which are of two types three
+
+11
+00:01:10,500 --> 00:01:16,700
+morphemes and bound morphemes We are going to
+
+12
+00:01:16,700 --> 00:01:22,760
+focus on three points derivation inflection and
+
+13
+00:01:23,120 --> 00:01:26,360
+compounding today we are going to focus on the
+
+14
+00:01:26,360 --> 00:01:35,900
+first point that is derivation okay most
+
+15
+00:01:35,900 --> 00:01:40,940
+of the English words are derived from this system
+
+16
+00:01:40,940 --> 00:01:43,420
+I mean derivation
+
+17
+00:01:47,640 --> 00:01:51,880
+So the derived elements, I mean suffixes or
+
+18
+00:01:51,880 --> 00:01:56,760
+prefixes or infixes, can change the meaning of a
+
+19
+00:01:56,760 --> 00:01:57,060
+word.
+
+20
+00:02:00,940 --> 00:02:06,720
+Okay? For example, true and true. Okay? You have
+
+21
+00:02:06,720 --> 00:02:07,260
+the opposite.
+
+22
+00:02:10,970 --> 00:02:14,110
+And also you have the derivation changing the
+
+23
+00:02:14,110 --> 00:02:18,730
+lexical category of a word. For example, true is
+
+24
+00:02:18,730 --> 00:02:26,510
+an adjective, truly is an adverb, truth is a noun.
+
+25
+00:03:05,120 --> 00:03:06,560
+So you have.
+
+26
+00:03:23,800 --> 00:03:29,660
+In derivation, the meaning of a word can change or
+
+27
+00:03:29,660 --> 00:03:34,000
+the lexical category of the word can change. Okay?
+
+28
+00:03:34,520 --> 00:03:40,820
+We need to touch these phenomena one by one and
+
+29
+00:03:40,820 --> 00:03:48,020
+see how nouns are derived from nouns. Yes. And how
+
+30
+00:03:48,020 --> 00:03:51,680
+other elements or parts of speech are derived from
+
+31
+00:03:51,680 --> 00:03:58,920
+each other. so we have suffixes that mean small
+
+32
+00:03:58,920 --> 00:04:08,380
+such as drop droplet droplet you add let okay
+
+33
+00:04:08,380 --> 00:04:18,520
+becomes smaller than drop book booklet let
+
+34
+00:04:18,520 --> 00:04:22,780
+is smaller than booklet is smaller than book
+
+35
+00:04:25,310 --> 00:04:32,790
+cigar cigarette e-t-t-e it's smaller than cigar
+
+36
+00:04:32,790 --> 00:04:35,990
+dog
+
+37
+00:04:35,990 --> 00:04:43,570
+doggy smaller than dog this is by adding ie and we
+
+38
+00:04:43,570 --> 00:04:47,310
+have doubling here because the last consonant is
+
+39
+00:04:47,310 --> 00:04:52,300
+preceded by a short vowel okay in case of having a
+
+40
+00:04:52,300 --> 00:04:59,060
+short vowel then we double the last consonant we
+
+41
+00:04:59,060 --> 00:05:05,320
+have suffixes only for making female for gender so
+
+42
+00:05:05,320 --> 00:05:15,980
+ess or ine waiter waitress prince princess hero
+
+43
+00:05:15,980 --> 00:05:22,490
+heroine okay So we have these two suffixes added
+
+44
+00:05:22,490 --> 00:05:26,030
+to the word itself, changing its meaning.
+
+45
+00:05:28,710 --> 00:05:34,110
+We have also suffixes specifically for making
+
+46
+00:05:34,110 --> 00:05:35,670
+nationalities.
+
+47
+00:05:37,290 --> 00:05:45,630
+I say Palestine, Palestinian. London, Landler. New
+
+48
+00:05:45,630 --> 00:05:49,790
+York, New Yorker. You see?
+
+49
+00:05:52,590 --> 00:05:55,890
+Texan. Glaswegian from Glasgow.
+
+50
+00:05:59,830 --> 00:06:10,570
+We have some suffixes for making state of being,
+
+51
+00:06:10,770 --> 00:06:14,750
+the manner, the position, the position of someone.
+
+52
+00:06:15,390 --> 00:06:23,890
+Ship. Hood. I say king, kingship. Lady, ladyship.
+
+53
+00:06:24,570 --> 00:06:33,230
+Mother, motherhood. Priest, priesthood. Okay? We
+
+54
+00:06:33,230 --> 00:06:37,970
+have some suffixes just for making devotion. I
+
+55
+00:06:37,970 --> 00:06:43,540
+mean professions and handicrafts. The profession
+
+56
+00:06:43,540 --> 00:06:48,500
+of someone. It is a noun. This is done by adding I
+
+57
+00:06:48,500 --> 00:06:56,800
+-S-T or I-A-N. We have contortion, contortionist.
+
+58
+00:06:58,000 --> 00:07:04,700
+Islam, Islamist. Logic, logician. History,
+
+59
+00:07:05,360 --> 00:07:05,840
+historian.
+
+60
+00:07:14,470 --> 00:07:20,010
+technician linguistician we have nouns derived
+
+61
+00:07:20,010 --> 00:07:24,050
+from adjectives by adding ity when i say for
+
+62
+00:07:24,050 --> 00:07:30,010
+example pure pure is an adjective okay adding ity
+
+63
+00:07:30,010 --> 00:07:35,810
+becomes purity and this is a noun equal is an
+
+64
+00:07:35,810 --> 00:07:39,230
+adjective equality it is a noun
+
+65
+00:07:44,780 --> 00:07:52,400
+Furcity. Sensitivity. Sensitive. Sensitivity. We
+
+66
+00:07:52,400 --> 00:07:58,840
+have N-E-S-S-ness. Okay? Also derived, we have
+
+67
+00:07:58,840 --> 00:08:01,980
+nouns derived from adjectives by adding N-E-S-S.
+
+68
+00:08:02,640 --> 00:08:11,180
+God. Goodness. Tall. Tallness. Forest. Or fierce.
+
+69
+00:08:12,060 --> 00:08:18,250
+Fierceness. Sensitive, sensitiveness as it is
+
+70
+00:08:18,250 --> 00:08:20,050
+completely like sensitivity.
+
+71
+00:08:22,970 --> 00:08:28,610
+ISM, I mean in the part of speech, both are nouns.
+
+72
+00:08:30,030 --> 00:08:34,070
+ISMism as radical, radicalism.
+
+73
+00:08:40,010 --> 00:08:46,870
+Conservatism. American, Americanism, Palestinian,
+
+74
+00:08:47,670 --> 00:08:53,850
+Palestinianism, okay? These are nouns derived from
+
+75
+00:08:53,850 --> 00:08:58,290
+adjectives. We now have nouns derived from verbs,
+
+76
+00:08:59,110 --> 00:09:06,710
+okay? And here we have a number of suffixes used
+
+77
+00:09:06,710 --> 00:09:16,250
+for deriving nouns from verbs. We use ance, as in
+
+78
+00:09:16,250 --> 00:09:23,130
+perform, performance, ignore, ignorance, refer,
+
+79
+00:09:24,310 --> 00:09:30,090
+reference, convert or converge, convergence,
+
+80
+00:09:31,370 --> 00:09:38,750
+accept, acceptance, dependence, Okay, we have also
+
+81
+00:09:38,750 --> 00:09:43,650
+a suffix called mint m-e-n-t Okay announce
+
+82
+00:09:43,650 --> 00:09:54,190
+announcement commit commitment develop development
+
+83
+00:09:54,190 --> 00:10:04,290
+engage engagement agree place placement Okay we
+
+84
+00:10:04,290 --> 00:10:10,770
+have also Nouns derived from verbs by adding ing
+
+85
+00:10:10,770 --> 00:10:22,250
+paint painting sing Build Ignore Okay, right
+
+86
+00:10:22,250 --> 00:10:32,730
+Listen speak dive Yes, this is by adding only ing
+
+87
+00:10:32,730 --> 00:10:44,990
+Okay we have ion this
+
+88
+00:10:44,990 --> 00:10:50,570
+is added or tion this is added to the verb and
+
+89
+00:10:50,570 --> 00:10:58,350
+this comes out with a noun denomination
+
+90
+00:10:58,350 --> 00:11:05,790
+sorry denomination this is from denominate commit
+
+91
+00:11:05,790 --> 00:11:14,150
+commission organize organization confuse confusion
+
+92
+00:11:14,150 --> 00:11:19,950
+confusion okay we have al added to the verb comes
+
+93
+00:11:19,950 --> 00:11:30,590
+out with a noun refuse arrive refer commit ahkel
+
+94
+00:11:30,590 --> 00:11:37,860
+committed propose Yes. We have also ER or OR.
+
+95
+00:11:38,160 --> 00:11:43,940
+Paint. Painter. Sing. Sing. Organize. Organize.
+
+96
+00:11:44,440 --> 00:11:48,720
+Grinder. Grinder. Grinder. As you see these are
+
+97
+00:11:48,720 --> 00:11:53,100
+professions or handicrafts. They are done by
+
+98
+00:11:53,100 --> 00:11:57,000
+adding ER. So you refer to someone, you refer to
+
+99
+00:11:57,000 --> 00:11:59,140
+the profession of someone or the handicraft of
+
+100
+00:11:59,140 --> 00:12:03,460
+someone by adding ER. I say farm. Farmer. Farmer.
+
+101
+00:12:06,760 --> 00:12:12,200
+build okay we
+
+102
+00:12:12,200 --> 00:12:18,560
+have or as in lead leader act actor direct
+
+103
+00:12:18,560 --> 00:12:24,180
+director okay and sometimes we have the prefix the
+
+104
+00:12:24,180 --> 00:12:28,280
+suffix y added to the verb comes this comes out
+
+105
+00:12:28,280 --> 00:12:32,920
+with a noun as in deliver delivery flatter
+
+106
+00:12:34,840 --> 00:12:38,020
+Discover. Discovering. Recover. Recovering.
+
+107
+00:12:42,980 --> 00:12:52,320
+We have acy, suffix, comes out with nouns. So we
+
+108
+00:12:52,320 --> 00:12:55,060
+have nouns derived from a number of words by
+
+109
+00:12:55,060 --> 00:13:00,680
+adding these suffixes. Acy or age, a-g-e or dumb,
+
+110
+00:13:00,800 --> 00:13:08,010
+d-o-m or e-r-y or r-y. So we have conspiracy from
+
+111
+00:13:08,010 --> 00:13:17,970
+conspire supremacy from supreme coin coinage short
+
+112
+00:13:17,970 --> 00:13:30,030
+percent shrink king free duke or duke dukedom
+
+113
+00:13:30,030 --> 00:13:33,730
+slave refined
+
+114
+00:13:37,640 --> 00:13:41,640
+refinery now we have adjectives derived from other
+
+115
+00:13:41,640 --> 00:13:49,580
+adjectives this is referring to the smallest
+
+116
+00:13:49,580 --> 00:13:57,680
+degree of things I say for example green okay this
+
+117
+00:13:57,680 --> 00:14:02,220
+is dark green I need to have it as light green I
+
+118
+00:14:02,220 --> 00:14:10,370
+say greenish Brown, brownish. Small, smallish.
+
+119
+00:14:11,150 --> 00:14:17,150
+Okay? So the I-S-H-ish refers to the small
+
+120
+00:14:17,150 --> 00:14:24,390
+quantity or the small quality. Okay? Remote,
+
+121
+00:14:25,390 --> 00:14:26,070
+remotish.
+
+122
+00:14:28,550 --> 00:14:29,670
+Okay?
+
+123
+00:14:34,510 --> 00:14:41,770
+we have the prefix that is also shown
+
+124
+00:14:41,770 --> 00:14:45,610
+to the beginning of a word or an adjective this
+
+125
+00:14:45,610 --> 00:14:48,410
+comes out with another adjective I say for example
+
+126
+00:14:48,410 --> 00:14:51,850
+for the previous items green this is adjective
+
+127
+00:14:51,850 --> 00:14:57,430
+when I say greenish suffix still adjective small
+
+128
+00:14:57,430 --> 00:15:02,860
+adjective smallish remains adjective okay remote
+
+129
+00:15:02,860 --> 00:15:09,340
+remote is also adjective remotish is adjective so
+
+130
+00:15:09,340 --> 00:15:14,160
+once we have happy unhappy this is another
+
+131
+00:15:14,160 --> 00:15:22,520
+adjective reliable and reliable sure and sure
+
+132
+00:15:22,520 --> 00:15:27,620
+discovered okay and discover
+
+133
+00:15:30,370 --> 00:15:35,990
+so these oh i mean the un or n is very productive
+
+134
+00:15:35,990 --> 00:15:41,550
+prefix can be added to any adjective making the
+
+135
+00:15:41,550 --> 00:15:47,750
+opposite okay the antonym of the same adjective
+
+136
+00:15:50,940 --> 00:15:55,140
+we have other prefixes for making adjectives like
+
+137
+00:15:55,140 --> 00:16:06,640
+ir im dis mis non okay so you have tangible this
+
+138
+00:16:06,640 --> 00:16:16,020
+is intangible legal illegal okay responsible
+
+139
+00:16:17,260 --> 00:16:20,800
+Responsible, not irresponsible, this is Arabic
+
+140
+00:16:20,800 --> 00:16:23,920
+Responsible,
+
+141
+00:16:24,440 --> 00:16:30,160
+irresponsible, okay, possible, impossible
+
+142
+00:16:33,130 --> 00:16:36,610
+We have other productive prefixes. I mean, you can
+
+143
+00:16:36,610 --> 00:16:40,610
+add it before or add it to the beginning of an
+
+144
+00:16:40,610 --> 00:16:43,050
+adjective that comes out with the antonym of the
+
+145
+00:16:43,050 --> 00:16:48,590
+same adjective. Like DIS as in order, disorder.
+
+146
+00:16:49,290 --> 00:16:55,970
+Obey, disobey. Trust, mistrust. Understand,
+
+147
+00:16:56,910 --> 00:17:01,670
+misunderstand. Cooperative, non-cooperative.
+
+148
+00:17:02,420 --> 00:17:04,980
+Existent? Okay.
+
+149
+00:17:10,580 --> 00:17:16,280
+Still, we have suffixes added to a number of
+
+150
+00:17:16,280 --> 00:17:21,200
+words. This comes out with other parts of speech,
+
+151
+00:17:22,020 --> 00:17:28,300
+mainly adjectives. We have able as in or ed. I
+
+152
+00:17:28,300 --> 00:17:32,500
+say, for example, break, breakable. okay it is
+
+153
+00:17:32,500 --> 00:17:39,120
+liable to breaking okay agree agreeable remarkable
+
+154
+00:17:39,120 --> 00:17:47,120
+remark remarkable rely reliable read right
+
+155
+00:17:47,120 --> 00:17:55,340
+writeable okay we have e and t or a and t int or
+
+156
+00:17:55,340 --> 00:17:56,980
+ent this is
+
+157
+00:18:01,150 --> 00:18:09,650
+Rebel. Rebellent. Expect. Expectant. Excellent.
+
+158
+00:18:09,950 --> 00:18:18,810
+Excel. Excellent. Confide. Confident. Dependent.
+
+159
+00:18:19,130 --> 00:18:27,290
+We have also the suffix IVE as repulse. Repulsive.
+
+160
+00:18:28,250 --> 00:18:35,960
+Explore. Explores. Explosives create, attract,
+
+161
+00:18:36,920 --> 00:18:39,120
+select, prevent,
+
+162
+00:18:41,560 --> 00:18:47,220
+instruct, instructive We
+
+163
+00:18:47,220 --> 00:18:52,380
+have suffixes also made from nouns by adding f-u-l
+
+164
+00:18:52,380 --> 00:19:00,020
+full as in joy Joy is a noun joyful hope help
+
+165
+00:19:02,180 --> 00:19:11,600
+Meaning meaning Okay power skill faith Beautiful
+
+166
+00:19:11,600 --> 00:19:18,840
+sorry beauty Success Also, we have the antonym or
+
+167
+00:19:18,840 --> 00:19:24,480
+the opposite derived by from the same noun By
+
+168
+00:19:24,480 --> 00:19:32,430
+adding le WS becomes Adjective, joy, joyousness,
+
+169
+00:19:32,730 --> 00:19:38,990
+hope, hopeless, help, meaningless, meaning, yes,
+
+170
+00:19:39,510 --> 00:19:48,410
+power, home, worth, use, yes. So we have also al
+
+171
+00:19:48,410 --> 00:19:52,890
+as a suffix added to the noun. This comes out with
+
+172
+00:19:52,890 --> 00:20:00,070
+an adjective, origin, normal, sorry, norm, person
+
+173
+00:20:00,070 --> 00:20:12,430
+nation national universe region regional also
+
+174
+00:20:12,430 --> 00:20:17,730
+once you need to make i to add ish this is for
+
+175
+00:20:17,730 --> 00:20:25,610
+making the least degree when i say boy boy boy
+
+176
+00:20:26,590 --> 00:20:40,050
+boyish okay self selfish okay wasp waspish lout
+
+177
+00:20:40,050 --> 00:20:48,750
+louty loutish loutish fool foolish child sheep
+
+178
+00:20:48,750 --> 00:20:54,650
+sheepish okay why this is added added to the noun
+
+179
+00:20:54,650 --> 00:21:01,010
+making adjective fun why do we add another n why
+
+180
+00:21:01,010 --> 00:21:04,490
+we double the n because it is preceded by a short
+
+181
+00:21:04,490 --> 00:21:14,970
+vowel so fun funny storm sun sunny guilt mess
+
+182
+00:21:14,970 --> 00:21:22,190
+wealth gloom as you see so we can also have in y
+
+183
+00:21:23,000 --> 00:21:27,300
+okay for making adjectives not adverbs we speak
+
+184
+00:21:27,300 --> 00:21:31,180
+about adjectives the ly is the productive suffix
+
+185
+00:21:31,180 --> 00:21:34,600
+for making adverbs still it is used for making
+
+186
+00:21:34,600 --> 00:21:42,320
+adjectives friend friendly order orderly man cost
+
+187
+00:21:42,320 --> 00:21:49,480
+month these are adjectives not adverbs we have ous
+
+188
+00:21:51,840 --> 00:21:56,840
+added to the noun making an adjective as in danger
+
+189
+00:21:56,840 --> 00:22:07,420
+dangerous mystery mysterious fame nerve poison
+
+190
+00:22:07,420 --> 00:22:14,600
+okay poisonous still we have adjectives made from
+
+191
+00:22:14,600 --> 00:22:22,060
+nouns by adding ary as in moment moment Momentary.
+
+192
+00:22:22,180 --> 00:22:27,560
+Custom. Customary. Fragment. Fragmentary.
+
+193
+00:22:28,740 --> 00:22:35,920
+Complement. Complementary. Honor. Revolution.
+
+194
+00:22:36,960 --> 00:22:44,440
+Revolutionary. I see. Ik. As in history. Artist.
+
+195
+00:22:46,300 --> 00:22:50,440
+Athlete. Athletic. Basis.
+
+196
+00:22:53,470 --> 00:23:03,910
+rhythm photograph Islam scientist or science okay
+
+197
+00:23:03,910 --> 00:23:10,190
+scientist or science this comes out from by adding
+
+198
+00:23:10,190 --> 00:23:19,410
+two suffixes T F I C T I F plus I C so scientific
+
+199
+00:23:23,940 --> 00:23:32,780
+Okay We have Realist Realistic, okay, we can add
+
+200
+00:23:32,780 --> 00:23:37,660
+also some to the Adjective
+
+201
+00:23:37,660 --> 00:23:45,880
+Making adve to the noun making adjective hand love
+
+202
+00:23:45,880 --> 00:23:47,700
+tire
+
+203
+00:23:48,940 --> 00:23:54,040
+yes also we can add en for making adjectives from
+
+204
+00:23:54,040 --> 00:24:03,880
+noun wood wool gold yes we have verbs derived from
+
+205
+00:24:03,880 --> 00:24:15,100
+verbs okay this is by adding the prefix de or dis
+
+206
+00:24:15,100 --> 00:24:21,520
+okay or RE this is productive when I say paint
+
+207
+00:24:21,520 --> 00:24:33,580
+repaint enter write read okay explain complain
+
+208
+00:24:33,580 --> 00:24:41,840
+recomplain okay so this is productive prefix added
+
+209
+00:24:41,840 --> 00:24:47,490
+to the verb It refers to repetitive actions. You
+
+210
+00:24:47,490 --> 00:24:50,970
+need to repeat, so you say rewrite it. Re-read,
+
+211
+00:24:51,590 --> 00:24:57,610
+okay? Re-utter it once again, okay? Re-say it once
+
+212
+00:24:57,610 --> 00:25:03,190
+again. Paint, repaint. Enter, re-enter. Tie,
+
+213
+00:25:04,750 --> 00:25:09,390
+untie. This is the antonym, okay? The opposite.
+
+214
+00:25:10,930 --> 00:25:11,690
+Tangible.
+
+215
+00:25:15,170 --> 00:25:20,690
+Sorry, entangle, untangle. Decompose, this comes
+
+216
+00:25:20,690 --> 00:25:27,470
+from originally compose. Synthesize, yes.
+
+217
+00:25:28,130 --> 00:25:35,730
+Entangle, disentangle. Believe, disbelieve. Okay?
+
+218
+00:25:38,150 --> 00:25:45,870
+We have verbs derived from nouns. Okay? This is by
+
+219
+00:25:45,870 --> 00:25:52,450
+having the prefix de, as in bug, debug, forest,
+
+220
+00:25:53,290 --> 00:26:00,210
+deforest, laus, delaus. And also we have ize, as
+
+221
+00:26:00,210 --> 00:26:09,530
+in organ, organize, patron, terror, real, realize.
+
+222
+00:26:10,290 --> 00:26:16,410
+Okay? We have material, Apology? Apologize.
+
+223
+00:26:16,730 --> 00:26:22,490
+Critic? Criticize. Okay. Beauty? Beautify.
+
+224
+00:26:22,910 --> 00:26:24,710
+Beautify. We add FY.
+
+225
+00:26:27,410 --> 00:26:35,310
+Gentry? Gentrify. Petri? Petrify. Identity?
+
+226
+00:26:35,690 --> 00:26:41,470
+Identify. Identify. Clarity? Clarity. Glory?
+
+227
+00:26:42,050 --> 00:26:47,850
+Glory. Simple? Simple. Simplify. Pressure.
+
+228
+00:26:48,630 --> 00:26:56,650
+Pressure. Pressurize. Normal. Normalize.
+
+229
+00:26:58,630 --> 00:27:02,310
+Natural. Naturalize.
+
+230
+00:27:06,270 --> 00:27:11,730
+Passive. Passive. Passivize.
+
+231
+00:27:16,720 --> 00:27:21,120
+okay we have verbs derived from other classes by
+
+232
+00:27:21,120 --> 00:27:26,840
+adding en to the adjective i say short shortened
+
+233
+00:27:26,840 --> 00:27:35,960
+sweet length black wide broad this is by adding en
+
+234
+00:27:35,960 --> 00:27:43,250
+as you see we have de this is for Having a verb by
+
+235
+00:27:43,250 --> 00:27:56,410
+adding prefix when I say move remove Okay Okay
+
+236
+00:27:56,410 --> 00:28:07,550
+sensitive desensitive freeze defreeze Humilate
+
+237
+00:28:07,550 --> 00:28:09,850
+dehumilate
+
+238
+00:28:10,840 --> 00:28:11,340
+Okay?
+
+239
+00:28:19,580 --> 00:28:24,140
+We have the
+
+240
+00:28:24,710 --> 00:28:31,950
+Ize or ify normally added as suffixes for making
+
+241
+00:28:31,950 --> 00:28:37,210
+nouns for making verbs from nouns okay let's say
+
+242
+00:28:37,210 --> 00:28:42,510
+normal normalize beauty beautify but still they
+
+243
+00:28:42,510 --> 00:28:46,450
+can be used for other purposes okay so we don't
+
+244
+00:28:46,450 --> 00:28:51,870
+have specific or specific meaning to these two
+
+245
+00:28:51,870 --> 00:28:59,200
+suffixes I'd say for example national nationalize
+
+246
+00:28:59,200 --> 00:29:08,960
+tender tenderize intense intensify pure purify
+
+247
+00:29:08,960 --> 00:29:17,000
+okay we have adverbs the productive suffix for
+
+248
+00:29:17,000 --> 00:29:23,400
+making adverbs is always NY so we have easy sorry
+
+249
+00:29:23,400 --> 00:29:33,040
+easy easily recent recently private noise noisy
+
+250
+00:29:33,040 --> 00:29:41,760
+noisily socially socially also we have the suffix
+
+251
+00:29:41,760 --> 00:29:51,100
+wise w i s e clockwise value, value wise okay it
+
+252
+00:29:51,100 --> 00:29:54,940
+is rarely used but the most productive suffix is
+
+253
+00:29:54,940 --> 00:30:01,200
+the ly okay we
+
+254
+00:30:01,200 --> 00:30:08,400
+have prefixes okay added for making adverbs when i
+
+255
+00:30:08,400 --> 00:30:13,140
+say for example sedent antecedent ante what does
+
+256
+00:30:13,140 --> 00:30:18,760
+it mean ante here in have a and te means first but
+
+257
+00:30:18,760 --> 00:30:23,560
+anti or anti in american english it is against
+
+258
+00:30:23,560 --> 00:30:32,860
+auto means self by means two tri three okay
+
+259
+00:30:32,860 --> 00:30:40,840
+trilingual what does it mean trilingual a person
+
+260
+00:30:40,840 --> 00:30:45,540
+speaking three languages bilingual person speaking
+
+261
+00:30:45,540 --> 00:30:50,420
+two languages multilingual okay so a person
+
+262
+00:30:50,420 --> 00:30:53,300
+speaking a number of languages so multi means
+
+263
+00:30:53,300 --> 00:31:01,200
+numerous yes
+
+264
+00:31:01,200 --> 00:31:09,340
+as i mentioned anti this is meaning before anti or
+
+265
+00:31:09,340 --> 00:31:14,510
+anti means against auto means self by means to
+
+266
+00:31:14,510 --> 00:31:22,250
+circum means around kun
+
+267
+00:31:22,250 --> 00:31:29,290
+or ku means together okay when
+
+268
+00:31:29,290 --> 00:31:37,230
+i have out means
+
+269
+00:31:37,230 --> 00:31:45,110
+from or from it is here we have Inter means
+
+270
+00:31:45,110 --> 00:31:45,570
+between.
+
+271
+00:31:49,750 --> 00:31:55,550
+Intercontinental means between continents.
+
+272
+00:31:56,470 --> 00:32:02,270
+Macro means large. Micro, when I say micro
+
+273
+00:32:02,270 --> 00:32:09,180
+teaching, Okay, a sample class done by the
+
+274
+00:32:09,180 --> 00:32:12,640
+teachers to the teachers. Okay, micro teaching.
+
+275
+00:32:13,120 --> 00:32:17,800
+But macro teaching is the larger process. Miss
+
+276
+00:32:17,800 --> 00:32:25,020
+means wrong. Mono means well. Monolingual can a
+
+277
+00:32:25,020 --> 00:32:30,060
+person speaking one language. Post means behind or
+
+278
+00:32:30,060 --> 00:32:30,440
+after.
+
+279
+00:32:34,780 --> 00:32:43,000
+okay before يعني first proof for when I say I'm
+
+280
+00:32:43,000 --> 00:32:50,560
+pro-Palestinians supporting Palestinians okay for
+
+281
+00:32:50,560 --> 00:32:57,100
+means for pro means for against this is anti
+
+282
+00:32:57,100 --> 00:33:01,420
+-Palestinian okay for example re means repeat
+
+283
+00:33:01,420 --> 00:33:12,560
+rewrite reread okay redo etc sub I say group
+
+284
+00:33:12,560 --> 00:33:16,540
+subgroup sub subgroup so you divide you check you
+
+285
+00:33:16,540 --> 00:33:22,260
+divide things means under trans means across
+
+286
+00:33:22,260 --> 00:33:29,660
+parent transparent transparency okay try means
+
+287
+00:33:29,660 --> 00:33:31,940
+three unique
+
+288
+00:33:33,300 --> 00:33:37,100
+Unilateral talks. Unilateral talks.
+
+289
+00:33:43,040 --> 00:33:55,100
+Ultra beyond, ultrasound. UN or IR or IN means
+
+290
+00:33:55,100 --> 00:33:55,900
+not.
+
+291
+00:34:02,800 --> 00:34:10,360
+So we have these derivations in English. Now these
+
+292
+00:34:10,360 --> 00:34:13,280
+derivations are of different types as you see.
+
+293
+00:34:14,640 --> 00:34:21,880
+Why? It is borrowing. As I mentioned English
+
+294
+00:34:21,880 --> 00:34:27,390
+borrowed from a number of languages so it borrowed
+
+295
+00:34:27,390 --> 00:34:35,770
+the system of suffixes or prefixes or say affixes
+
+296
+00:34:35,770 --> 00:34:41,550
+okay with all its three types suffixes prefixes
+
+297
+00:34:41,550 --> 00:34:47,170
+and infixes so you have some words by certain
+
+298
+00:34:47,170 --> 00:34:52,310
+suffixes producing nouns some other words by
+
+299
+00:34:52,310 --> 00:34:56,370
+certain suffixes producing the same nouns the
+
+300
+00:34:56,370 --> 00:35:01,930
+adjectives the adverbs we have prefixes for making
+
+301
+00:35:01,930 --> 00:35:06,310
+nouns for making adjectives for making verbs for
+
+302
+00:35:06,310 --> 00:35:11,930
+making adverbs okay so we don't have specific rule
+
+303
+00:35:11,930 --> 00:35:16,950
+for making or for deriving words from words mainly
+
+304
+00:35:16,950 --> 00:35:22,030
+because English relies deeply on borrowing however
+
+305
+00:35:22,030 --> 00:35:26,930
+Arabic in Arabic the situation is different we
+
+306
+00:35:26,930 --> 00:35:32,410
+have a rule-based system in Arabic okay so we have
+
+307
+00:35:32,410 --> 00:35:38,030
+either prefixes infixes and suffixes but before
+
+308
+00:35:38,030 --> 00:35:42,470
+shifting to Arabic I need to focus on infixes in
+
+309
+00:35:42,470 --> 00:35:49,430
+English when I say for example man men okay here
+
+310
+00:35:49,430 --> 00:35:57,610
+we add infix we change the a into e mouse mice
+
+311
+00:35:59,450 --> 00:36:05,250
+Louse. Lice. Okay. These are infixes, but they are
+
+312
+00:36:05,250 --> 00:36:06,730
+rare in English.
+
+313
+00:36:10,090 --> 00:36:16,030
+Okay. However, in Arabic, it's very rich of
+
+314
+00:36:16,030 --> 00:36:25,030
+infixes. It's very rich of infixes. So we have كتب
+
+315
+00:36:25,030 --> 00:36:28,410
+or كتب, triconsonantal sound.
+
+316
+00:36:31,880 --> 00:36:38,680
+this is the verb derived from the stem by adding
+
+317
+00:36:38,680 --> 00:36:46,840
+what? the short vowels a o e I mean the nominative
+
+318
+00:36:46,840 --> 00:36:55,020
+case the accusative and genitive okay we
+
+319
+00:36:55,020 --> 00:37:05,680
+have كتب كتب مكتب is this suffix or prefix? prefix
+
+320
+00:37:05,680 --> 00:37:11,520
+added to the verb constituting or formulating a
+
+321
+00:37:11,520 --> 00:37:17,900
+noun مكاتب we
+
+322
+00:37:17,900 --> 00:37:27,880
+add infix ألف كاتب infix كاتبة مكاتبة
+
+323
+00:37:29,000 --> 00:37:35,520
+Suffix type now gender in English in Arabic is
+
+324
+00:37:35,520 --> 00:37:42,880
+made by the clitic Ta or Ta marbuta okay this is
+
+325
+00:37:42,880 --> 00:37:48,440
+very productive in English so I say for example
+
+326
+00:37:48,440 --> 00:37:49,820
+doctor
+
+327
+00:37:53,330 --> 00:37:59,470
+In Arabic, I say doctora. This is inserted in our
+
+328
+00:37:59,470 --> 00:38:03,850
+colloquial Arabic, in our Arabic vernaculars. So
+
+329
+00:38:03,850 --> 00:38:09,690
+we have this, tabib, tabiba. Okay, but this is
+
+330
+00:38:09,690 --> 00:38:13,990
+very difficult. This is not applicable to English.
+
+331
+00:38:14,730 --> 00:38:18,670
+I say doctor in English. I need my orido and
+
+332
+00:38:30,820 --> 00:38:36,800
+How could I translate it into English? To be seen
+
+333
+00:38:36,800 --> 00:38:41,920
+by a lady doctor. I'd like my wife to be seen by a
+
+334
+00:38:41,920 --> 00:38:46,580
+lady doctor. Okay? So here we have the clitic
+
+335
+00:38:46,580 --> 00:38:51,140
+system of Arabic, the clitic system of Arabic,
+
+336
+00:38:51,720 --> 00:38:58,100
+يعني ضمير الوصل in Arabic, clitic. We have the
+
+337
+00:38:58,100 --> 00:39:02,140
+clitic system ضمير الوصل. It's available in
+
+338
+00:39:02,140 --> 00:39:05,200
+Arabic. Is it available in English? No, we don't
+
+339
+00:39:05,200 --> 00:39:08,900
+have cliticization system in English, but we have
+
+340
+00:39:08,900 --> 00:39:15,020
+it in Arabic. So it is very productive. Okay. And
+
+341
+00:39:15,020 --> 00:39:21,480
+we have even fusional words in Arabic. I say a
+
+342
+00:39:21,480 --> 00:39:26,640
+complex sentence in one word as Asqaynakumu
+
+343
+00:39:26,640 --> 00:39:29,900
+Asqaynakumu.
+
+344
+00:39:30,520 --> 00:39:34,780
+This is the transitive verb. We have the subject,
+
+345
+00:39:35,220 --> 00:39:40,700
+the verb, direct object and indirect object. Okay.
+
+346
+00:39:40,960 --> 00:39:41,840
+Asqaynakumu.
+
+347
+00:39:45,680 --> 00:39:51,860
+Okay, so we have the clitic here Gender is very
+
+348
+00:39:51,860 --> 00:39:54,500
+productive in Arabic. This is done by adding a
+
+349
+00:39:54,500 --> 00:39:59,760
+suffix Ta Okay, but this is not applicable to
+
+350
+00:39:59,760 --> 00:40:02,800
+English and this shows the difficulty of the
+
+351
+00:40:02,800 --> 00:40:09,380
+English morphology you see So
+
+352
+00:40:09,380 --> 00:40:16,750
+Tabiba this is suffix Okay We have this applicable
+
+353
+00:40:16,750 --> 00:40:22,410
+to most of the nouns of Arabic, most of the verbs
+
+354
+00:40:22,410 --> 00:40:30,250
+of Arabic. So we can derive nouns from verbs.
+
+355
+00:40:35,010 --> 00:40:43,770
+Adjectives from nouns. I say حر حر برد برد. Okay.
+
+356
+00:40:48,850 --> 00:40:55,000
+Power. قوي okay so you have also nouns derived
+
+357
+00:40:55,000 --> 00:40:59,880
+from nouns adjectives derived from nouns nouns
+
+358
+00:40:59,880 --> 00:41:05,760
+derived from verbs but this is by adding prefix or
+
+359
+00:41:05,760 --> 00:41:11,260
+suffix or infix next time we are going to see more
+
+360
+00:41:11,260 --> 00:41:14,840
+information about the word formation of English
+
+361
+00:41:14,840 --> 00:41:18,420
+okay and Arabic as well and we are going to see
+
+362
+00:41:18,420 --> 00:41:21,980
+the inflection system plus what is called
+
+363
+00:41:21,980 --> 00:41:26,380
+compounding okay that's it for today thank you
+
diff --git a/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/erNGGnXXyiI_raw.json b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/erNGGnXXyiI_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..d244473d6806b43f7a9f0ae23565aed950b16d7c
--- /dev/null
+++ b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/erNGGnXXyiI_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2298, "start": 15.9, "end": 22.98, "text": " Bismillahirrahmanirrahim. Just last time, we spoke about consonance.", "tokens": [34594, 32703, 347, 15688, 1601, 347, 15688, 332, 13, 1449, 1036, 565, 11, 321, 7179, 466, 30843, 719, 13], "avg_logprob": -0.2798828065395355, "compression_ratio": 0.9857142857142858, "no_speech_prob": 0.0, "words": [{"start": 15.899999999999999, "end": 16.58, "word": " Bismillahirrahmanirrahim.", "probability": 0.784027099609375}, {"start": 19.0, "end": 19.68, "word": " Just", "probability": 0.8681640625}, {"start": 19.68, "end": 20.02, "word": " last", "probability": 0.875}, {"start": 20.02, "end": 20.36, "word": " time,", "probability": 0.888671875}, {"start": 20.64, "end": 21.64, "word": " we", "probability": 0.9638671875}, {"start": 21.64, "end": 21.92, "word": " spoke", "probability": 0.8564453125}, {"start": 21.92, "end": 22.24, "word": " about", "probability": 0.916015625}, {"start": 22.24, "end": 22.98, "word": " consonance.", "probability": 0.80126953125}], "temperature": 1.0}, {"id": 2, "seek": 5757, "start": 28.11, "end": 57.57, "text": " And we've seen that there is a remarkable difference between English and Arabic that causes negative interference, which results into interlingual errors. We've seen this in different sounds of English, like the bilabial sounds, p and b.", "tokens": [400, 321, 600, 1612, 300, 456, 307, 257, 12802, 2649, 1296, 3669, 293, 19938, 300, 7700, 3671, 24497, 11, 597, 3542, 666, 728, 1688, 901, 13603, 13, 492, 600, 1612, 341, 294, 819, 3263, 295, 3669, 11, 411, 264, 8588, 455, 831, 3263, 11, 280, 293, 272, 13], "avg_logprob": -0.1953125048656853, "compression_ratio": 1.5354838709677419, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 28.11, "end": 28.53, "word": " And", "probability": 0.5322265625}, {"start": 28.53, "end": 28.99, "word": " we've", "probability": 0.858154296875}, {"start": 28.99, "end": 29.29, "word": " seen", "probability": 0.95751953125}, {"start": 29.29, "end": 29.71, "word": " that", "probability": 0.93701171875}, {"start": 29.71, "end": 31.83, "word": " there", "probability": 0.8095703125}, {"start": 31.83, "end": 32.01, "word": " is", "probability": 0.88671875}, {"start": 32.01, "end": 32.23, "word": " a", 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0.826171875}, {"start": 40.93, "end": 42.61, "word": " into", "probability": 0.7080078125}, {"start": 42.61, "end": 43.43, "word": " interlingual", "probability": 0.861328125}, {"start": 43.43, "end": 44.45, "word": " errors.", "probability": 0.88232421875}, {"start": 45.49, "end": 45.99, "word": " We've", "probability": 0.94873046875}, {"start": 45.99, "end": 46.31, "word": " seen", "probability": 0.95458984375}, {"start": 46.31, "end": 46.77, "word": " this", "probability": 0.94482421875}, {"start": 46.77, "end": 47.91, "word": " in", "probability": 0.93701171875}, {"start": 47.91, "end": 49.21, "word": " different", "probability": 0.9072265625}, {"start": 49.21, "end": 49.67, "word": " sounds", "probability": 0.81103515625}, {"start": 49.67, "end": 49.87, "word": " of", "probability": 0.9599609375}, {"start": 49.87, "end": 50.31, "word": " English,", "probability": 0.98046875}, {"start": 51.27, "end": 51.59, "word": " like", "probability": 0.93798828125}, {"start": 51.59, "end": 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So this causes our students to pronounce such sounds into dental in English and come out with a heavy accent that cannot be understood by English native speakers. We still have problematic difficulty which is represented in other consonants and vowels.", "tokens": [1339, 436, 366, 24473, 294, 19938, 13, 407, 341, 7700, 527, 1731, 281, 19567, 1270, 3263, 666, 24473, 294, 3669, 293, 808, 484, 365, 257, 4676, 11982, 300, 2644, 312, 7320, 538, 3669, 8470, 9518, 13, 492, 920, 362, 19011, 10360, 597, 307, 10379, 294, 661, 30843, 1719, 293, 44972, 13], "avg_logprob": -0.12762920300547892, "compression_ratio": 1.5132275132275133, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 89.45, "end": 89.95, "word": " while", "probability": 0.88671875}, {"start": 89.95, "end": 90.19, "word": " they", "probability": 0.89453125}, {"start": 90.19, "end": 90.43, "word": " are", "probability": 0.94384765625}, {"start": 90.43, "end": 90.75, "word": " dental", "probability": 0.8427734375}, {"start": 90.75, "end": 91.03, "word": " in", "probability": 0.94580078125}, {"start": 91.03, "end": 91.43, "word": " Arabic.", "probability": 0.89208984375}, {"start": 92.55, "end": 92.67, "word": " So", "probability": 0.87109375}, {"start": 92.67, "end": 93.01, "word": " this", "probability": 0.7177734375}, {"start": 93.01, "end": 93.65, "word": " causes", "probability": 0.876953125}, {"start": 93.65, "end": 94.07, "word": " our", "probability": 0.8828125}, {"start": 94.07, "end": 94.71, "word": " students", "probability": 0.97509765625}, {"start": 94.71, "end": 95.85, "word": " to", "probability": 0.96484375}, {"start": 95.85, "end": 96.55, "word": " pronounce", "probability": 0.91943359375}, {"start": 96.55, "end": 97.01, "word": " such", "probability": 0.96044921875}, {"start": 97.01, "end": 97.61, "word": " sounds", "probability": 0.8671875}, {"start": 97.61, "end": 98.39, "word": " into", "probability": 0.759765625}, {"start": 98.39, "end": 101.25, "word": " dental", "probability": 0.84130859375}, {"start": 101.25, "end": 101.63, "word": " in", "probability": 0.943359375}, {"start": 101.63, "end": 102.05, "word": " English", "probability": 0.9794921875}, {"start": 102.05, "end": 103.01, "word": " and", "probability": 0.630859375}, {"start": 103.01, "end": 103.29, "word": " come", "probability": 0.8583984375}, {"start": 103.29, "end": 103.67, "word": " out", "probability": 0.8828125}, {"start": 103.67, "end": 103.89, "word": " with", "probability": 0.90087890625}, {"start": 103.89, "end": 104.03, "word": " a", "probability": 0.99365234375}, {"start": 104.03, "end": 104.25, "word": " heavy", "probability": 0.82080078125}, {"start": 104.25, "end": 104.71, "word": " accent", "probability": 0.92333984375}, {"start": 104.71, "end": 104.95, "word": " that", "probability": 0.92041015625}, {"start": 104.95, "end": 105.19, "word": " cannot", "probability": 0.880859375}, {"start": 105.19, "end": 105.43, "word": " be", "probability": 0.96484375}, {"start": 105.43, "end": 105.87, "word": " understood", "probability": 0.921875}, {"start": 105.87, "end": 106.29, "word": " by", "probability": 0.97265625}, {"start": 106.29, "end": 106.69, "word": " English", "probability": 0.97998046875}, {"start": 106.69, "end": 107.07, "word": " native", "probability": 0.83154296875}, {"start": 107.07, "end": 107.55, "word": " speakers.", "probability": 0.86572265625}, {"start": 108.89, "end": 109.63, "word": " We", "probability": 0.96240234375}, {"start": 109.63, "end": 110.03, "word": " still", "probability": 0.96337890625}, {"start": 110.03, "end": 111.23, "word": " have", "probability": 0.94580078125}, {"start": 111.23, "end": 111.83, "word": " problematic", "probability": 0.6474609375}, {"start": 111.83, "end": 112.61, "word": " difficulty", "probability": 0.740234375}, {"start": 112.61, "end": 114.01, "word": " which", "probability": 0.572265625}, {"start": 114.01, "end": 114.17, "word": " is", "probability": 0.9462890625}, {"start": 114.17, "end": 114.71, "word": " represented", "probability": 0.80517578125}, {"start": 114.71, "end": 115.27, "word": " in", "probability": 0.9482421875}, {"start": 115.27, "end": 116.25, "word": " other", "probability": 0.89404296875}, {"start": 116.25, "end": 117.27, "word": " consonants", "probability": 0.976806640625}, {"start": 117.27, "end": 118.25, "word": " and", "probability": 0.92724609375}, {"start": 118.25, "end": 118.67, "word": " vowels.", "probability": 0.98876953125}], "temperature": 1.0}, {"id": 5, "seek": 15113, "start": 122.02, "end": 151.14, "text": " We've seen the consonant doubling. There's no consonant doubling in English. The gemination is available in Arabic. Okay? So, we are going to see this today and see also the clusterization system. English has a number of clusters, while Arabic has only two clusters, either in the middle of a word", "tokens": [492, 600, 1612, 264, 43647, 33651, 13, 821, 311, 572, 43647, 33651, 294, 3669, 13, 440, 7173, 2486, 307, 2435, 294, 19938, 13, 1033, 30, 407, 11, 321, 366, 516, 281, 536, 341, 965, 293, 536, 611, 264, 13630, 2144, 1185, 13, 3669, 575, 257, 1230, 295, 23313, 11, 1339, 19938, 575, 787, 732, 23313, 11, 2139, 294, 264, 2808, 295, 257, 1349], "avg_logprob": -0.15270996512845159, "compression_ratio": 1.5851063829787233, "no_speech_prob": 0.0, "words": [{"start": 122.02, "end": 122.46, "word": " We've", "probability": 0.74560546875}, {"start": 122.46, "end": 122.86, "word": " seen", "probability": 0.95849609375}, {"start": 122.86, "end": 123.88, "word": " the", "probability": 0.8251953125}, {"start": 123.88, "end": 124.54, "word": " consonant", "probability": 0.8154296875}, {"start": 124.54, "end": 125.06, "word": " doubling.", "probability": 0.94189453125}, {"start": 125.98, "end": 126.56, "word": " There's", "probability": 0.714111328125}, {"start": 126.56, "end": 126.74, "word": " no", "probability": 0.953125}, {"start": 126.74, "end": 127.12, "word": " consonant", "probability": 0.90673828125}, {"start": 127.12, "end": 127.48, "word": " doubling", "probability": 0.93212890625}, {"start": 127.48, "end": 127.94, "word": " in", "probability": 0.95361328125}, {"start": 127.94, "end": 128.32, "word": " English.", "probability": 0.98046875}, {"start": 129.12, "end": 129.28, "word": " The", "probability": 0.89599609375}, {"start": 129.28, "end": 129.76, "word": " gemination", "probability": 0.69921875}, {"start": 129.76, "end": 130.04, "word": " is", "probability": 0.94873046875}, {"start": 130.04, "end": 130.5, "word": " available", "probability": 0.83544921875}, {"start": 130.5, "end": 130.76, "word": " in", "probability": 0.953125}, {"start": 130.76, "end": 131.06, "word": " Arabic.", "probability": 0.91064453125}, {"start": 132.3, "end": 132.66, "word": " Okay?", "probability": 0.60693359375}, {"start": 133.04, "end": 133.62, "word": " So,", "probability": 0.95556640625}, {"start": 134.5, "end": 134.94, "word": " we", "probability": 0.96484375}, {"start": 134.94, "end": 135.08, "word": " are", "probability": 0.90283203125}, {"start": 135.08, "end": 135.22, "word": " going", "probability": 0.94775390625}, {"start": 135.22, "end": 135.32, "word": " to", "probability": 0.970703125}, {"start": 135.32, "end": 135.48, "word": " see", "probability": 0.92529296875}, {"start": 135.48, "end": 135.88, "word": " this", "probability": 0.9453125}, {"start": 135.88, "end": 136.94, "word": " today", "probability": 0.82958984375}, {"start": 136.94, "end": 137.6, "word": " and", "probability": 0.63525390625}, {"start": 137.6, "end": 137.92, "word": " see", "probability": 0.8818359375}, {"start": 137.92, "end": 138.3, "word": " also", "probability": 0.84326171875}, {"start": 138.3, "end": 138.56, "word": " the", "probability": 0.91455078125}, {"start": 138.56, "end": 139.3, "word": " clusterization", "probability": 0.845458984375}, {"start": 139.3, "end": 139.82, "word": " system.", "probability": 0.94775390625}, {"start": 141.26, "end": 141.72, "word": " English", "probability": 0.97998046875}, {"start": 141.72, "end": 142.52, "word": " has", "probability": 0.94873046875}, {"start": 142.52, "end": 142.86, "word": " a", "probability": 0.9990234375}, {"start": 142.86, "end": 143.18, "word": " number", "probability": 0.927734375}, {"start": 143.18, "end": 143.48, "word": " of", "probability": 0.96875}, {"start": 143.48, "end": 143.92, "word": " clusters,", "probability": 0.9443359375}, {"start": 145.08, "end": 145.54, "word": " while", "probability": 0.9404296875}, {"start": 145.54, "end": 145.94, "word": " Arabic", "probability": 0.90478515625}, {"start": 145.94, "end": 147.22, "word": " has", "probability": 0.94677734375}, {"start": 147.22, "end": 147.54, "word": " only", "probability": 0.9248046875}, {"start": 147.54, "end": 147.78, "word": " two", "probability": 0.919921875}, {"start": 147.78, "end": 148.28, "word": " clusters,", "probability": 0.9365234375}, {"start": 149.16, "end": 149.5, "word": " either", "probability": 0.93896484375}, {"start": 149.5, "end": 150.08, "word": " in", "probability": 0.94970703125}, {"start": 150.08, "end": 150.28, "word": " the", "probability": 0.92041015625}, {"start": 150.28, "end": 150.5, "word": " middle", "probability": 0.95361328125}, {"start": 150.5, "end": 150.72, "word": " of", "probability": 0.97265625}, {"start": 150.72, "end": 150.9, "word": " a", "probability": 0.96826171875}, {"start": 150.9, "end": 151.14, "word": " word", "probability": 0.95263671875}], "temperature": 1.0}, {"id": 6, "seek": 17822, "start": 151.76, "end": 178.22, "text": "or at the end of a word. Okay? So, but English has two clusters, three clusters, four clusters, up to seven clusters. This means the consequence of more than seven clusters within one word or two words in connected utterance.", "tokens": [284, 412, 264, 917, 295, 257, 1349, 13, 1033, 30, 407, 11, 457, 3669, 575, 732, 23313, 11, 1045, 23313, 11, 1451, 23313, 11, 493, 281, 3407, 23313, 13, 639, 1355, 264, 18326, 295, 544, 813, 3407, 23313, 1951, 472, 1349, 420, 732, 2283, 294, 4582, 17567, 719, 13], "avg_logprob": -0.1491406214237213, "compression_ratio": 1.530612244897959, "no_speech_prob": 0.0, "words": [{"start": 151.76, "end": 152.24, "word": "or", "probability": 0.36865234375}, {"start": 152.24, "end": 152.66, "word": " at", "probability": 0.89111328125}, {"start": 152.66, "end": 152.8, "word": " the", "probability": 0.92626953125}, {"start": 152.8, "end": 152.98, "word": " end", "probability": 0.90380859375}, {"start": 152.98, "end": 153.12, "word": " of", "probability": 0.97314453125}, {"start": 153.12, "end": 153.3, "word": " a", "probability": 0.94140625}, {"start": 153.3, "end": 153.56, "word": " word.", "probability": 0.95361328125}, {"start": 154.5, "end": 154.64, "word": " Okay?", "probability": 0.4873046875}, {"start": 155.46, "end": 155.64, "word": " So,", "probability": 0.56787109375}, {"start": 155.74, "end": 155.84, "word": " but", "probability": 0.88916015625}, {"start": 155.84, "end": 156.18, "word": " English", "probability": 0.95703125}, {"start": 156.18, "end": 156.7, "word": " has", "probability": 0.95166015625}, {"start": 156.7, "end": 157.88, "word": " two", "probability": 0.83447265625}, {"start": 157.88, "end": 158.4, "word": " clusters,", "probability": 0.91748046875}, {"start": 159.04, "end": 159.42, "word": " three", "probability": 0.92578125}, {"start": 159.42, "end": 160.02, "word": " clusters,", "probability": 0.91943359375}, {"start": 160.88, "end": 161.18, "word": " four", "probability": 0.9365234375}, {"start": 161.18, "end": 161.8, "word": " clusters,", "probability": 0.92919921875}, {"start": 162.7, "end": 163.1, "word": " up", "probability": 0.97265625}, {"start": 163.1, "end": 163.48, "word": " to", "probability": 0.97412109375}, {"start": 163.48, "end": 164.06, "word": " seven", "probability": 0.9150390625}, {"start": 164.06, "end": 164.54, "word": " clusters.", "probability": 0.93603515625}, {"start": 166.52, "end": 167.5, "word": " This", "probability": 0.8955078125}, {"start": 167.5, "end": 167.92, "word": " means", "probability": 0.93359375}, {"start": 167.92, "end": 168.22, "word": " the", "probability": 0.8828125}, {"start": 168.22, "end": 168.8, "word": " consequence", "probability": 0.74072265625}, {"start": 168.8, "end": 169.96, "word": " of", "probability": 0.97412109375}, {"start": 169.96, "end": 170.3, "word": " more", "probability": 0.9404296875}, {"start": 170.3, "end": 170.8, "word": " than", "probability": 0.9482421875}, {"start": 170.8, "end": 171.98, "word": " seven", "probability": 0.90869140625}, {"start": 171.98, "end": 172.62, "word": " clusters", "probability": 0.9384765625}, {"start": 172.62, "end": 173.6, "word": " within", "probability": 0.87939453125}, {"start": 173.6, "end": 174.08, "word": " one", "probability": 0.93603515625}, {"start": 174.08, "end": 174.58, "word": " word", "probability": 0.93408203125}, {"start": 174.58, "end": 175.12, "word": " or", "probability": 0.86669921875}, {"start": 175.12, "end": 176.02, "word": " two", "probability": 0.94189453125}, {"start": 176.02, "end": 176.48, "word": " words", "probability": 0.853515625}, {"start": 176.48, "end": 176.88, "word": " in", "probability": 0.7353515625}, {"start": 176.88, "end": 177.48, "word": " connected", "probability": 0.873046875}, {"start": 177.48, "end": 178.22, "word": " utterance.", "probability": 0.849365234375}], "temperature": 1.0}, {"id": 7, "seek": 20361, "start": 180.43, "end": 203.61, "text": " This causes our students to commit also mistakes in pronunciation because every single sound of Arabic is followed, every single consonant of Arabic is followed by a vowel. And the short vowels of Arabic are the three short vowels, nominative, accusative, and genitive.", "tokens": [639, 7700, 527, 1731, 281, 5599, 611, 8038, 294, 23338, 570, 633, 2167, 1626, 295, 19938, 307, 6263, 11, 633, 2167, 43647, 295, 19938, 307, 6263, 538, 257, 29410, 13, 400, 264, 2099, 44972, 295, 19938, 366, 264, 1045, 2099, 44972, 11, 5369, 259, 1166, 11, 11168, 1166, 11, 293, 1049, 2187, 13], "avg_logprob": -0.16666666915019354, "compression_ratio": 1.6981132075471699, "no_speech_prob": 0.0, "words": [{"start": 180.43, "end": 180.75, "word": " This", "probability": 0.8857421875}, {"start": 180.75, "end": 181.17, "word": " causes", "probability": 0.888671875}, {"start": 181.17, "end": 181.55, "word": " our", "probability": 0.876953125}, {"start": 181.55, "end": 182.15, "word": " students", "probability": 0.97802734375}, {"start": 182.15, "end": 182.77, "word": " to", "probability": 0.95703125}, {"start": 182.77, "end": 183.15, "word": " commit", "probability": 0.6611328125}, {"start": 183.15, "end": 183.55, "word": " also", "probability": 0.6455078125}, {"start": 183.55, "end": 184.05, "word": " mistakes", "probability": 0.861328125}, {"start": 184.05, "end": 184.27, "word": " in", "probability": 0.94287109375}, {"start": 184.27, "end": 184.93, "word": " pronunciation", "probability": 0.9423828125}, {"start": 184.93, "end": 186.09, "word": " because", "probability": 0.478759765625}, {"start": 186.09, "end": 186.47, "word": " every", "probability": 0.818359375}, {"start": 186.47, "end": 186.81, "word": " single", "probability": 0.95361328125}, {"start": 186.81, "end": 187.27, "word": " sound", "probability": 0.7314453125}, {"start": 187.27, "end": 187.91, "word": " of", "probability": 0.951171875}, {"start": 187.91, "end": 188.33, "word": " Arabic", "probability": 0.9384765625}, {"start": 188.33, "end": 189.77, "word": " is", "probability": 0.79052734375}, {"start": 189.77, "end": 190.09, "word": " followed,", "probability": 0.90087890625}, {"start": 190.41, "end": 190.63, "word": " every", "probability": 0.828125}, {"start": 190.63, "end": 191.75, "word": " single", "probability": 0.56201171875}, {"start": 191.75, "end": 192.23, "word": " consonant", "probability": 0.91845703125}, {"start": 192.23, "end": 192.55, "word": " of", "probability": 0.96484375}, {"start": 192.55, "end": 192.85, "word": " Arabic", "probability": 0.92724609375}, {"start": 192.85, "end": 193.21, "word": " is", "probability": 0.88916015625}, {"start": 193.21, "end": 193.45, "word": " followed", "probability": 0.896484375}, {"start": 193.45, "end": 193.85, "word": " by", "probability": 0.9697265625}, {"start": 193.85, "end": 194.55, "word": " a", "probability": 0.99658203125}, {"start": 194.55, "end": 194.79, "word": " vowel.", "probability": 0.9755859375}, {"start": 195.83, "end": 195.97, "word": " And", "probability": 0.8427734375}, {"start": 195.97, "end": 196.09, "word": " the", "probability": 0.9072265625}, {"start": 196.09, "end": 196.37, "word": " short", "probability": 0.94921875}, {"start": 196.37, "end": 196.67, "word": " vowels", "probability": 0.98046875}, {"start": 196.67, "end": 196.89, "word": " of", "probability": 0.96484375}, {"start": 196.89, "end": 197.21, "word": " Arabic", "probability": 0.94189453125}, {"start": 197.21, "end": 197.89, "word": " are", "probability": 0.94140625}, {"start": 197.89, "end": 198.53, "word": " the", "probability": 0.91259765625}, {"start": 198.53, "end": 198.85, "word": " three", "probability": 0.92041015625}, {"start": 198.85, "end": 199.33, "word": " short", "probability": 0.94873046875}, {"start": 199.33, "end": 199.91, "word": " vowels,", "probability": 0.9833984375}, {"start": 200.37, "end": 201.03, "word": " nominative,", "probability": 0.8263346354166666}, {"start": 201.65, "end": 202.49, "word": " accusative,", "probability": 0.948486328125}, {"start": 202.99, "end": 203.23, "word": " and", "probability": 0.93994140625}, {"start": 203.23, "end": 203.61, "word": " genitive.", "probability": 0.91552734375}], "temperature": 1.0}, {"id": 8, "seek": 22389, "start": 206.23, "end": 223.89, "text": " So every single sound, every single consonant is followed by a vowel except only two consonants that come either in the middle or in the end. And also we have", "tokens": [407, 633, 2167, 1626, 11, 633, 2167, 43647, 307, 6263, 538, 257, 29410, 3993, 787, 732, 30843, 1719, 300, 808, 2139, 294, 264, 2808, 420, 294, 264, 917, 13, 400, 611, 321, 362], "avg_logprob": -0.2265625008765389, "compression_ratio": 1.4196428571428572, "no_speech_prob": 5.960464477539062e-07, "words": [{"start": 206.23000000000002, "end": 206.93, "word": " So", "probability": 0.2257080078125}, {"start": 206.93, "end": 207.61, "word": " every", "probability": 0.66650390625}, {"start": 207.61, "end": 208.05, "word": " single", "probability": 0.94677734375}, {"start": 208.05, "end": 208.57, "word": " sound,", "probability": 0.78759765625}, {"start": 208.97, "end": 209.15, "word": " every", "probability": 0.8349609375}, {"start": 209.15, "end": 209.47, "word": " single", "probability": 0.93408203125}, {"start": 209.47, "end": 209.93, "word": " consonant", "probability": 0.93115234375}, {"start": 209.93, "end": 210.49, "word": " is", "probability": 0.73681640625}, {"start": 210.49, "end": 210.73, "word": " followed", "probability": 0.9169921875}, {"start": 210.73, "end": 210.97, "word": " by", "probability": 0.97802734375}, {"start": 210.97, "end": 211.17, "word": " a", "probability": 0.9912109375}, {"start": 211.17, "end": 211.47, "word": " vowel", "probability": 0.9775390625}, {"start": 211.47, "end": 212.41, "word": " except", "probability": 0.65673828125}, {"start": 212.41, "end": 212.99, "word": " only", "probability": 0.84326171875}, {"start": 212.99, "end": 214.05, "word": " two", "probability": 0.91357421875}, {"start": 214.05, "end": 214.67, "word": " consonants", "probability": 0.970458984375}, {"start": 214.67, "end": 214.93, "word": " that", "probability": 0.92724609375}, {"start": 214.93, "end": 215.23, "word": " come", "probability": 0.86669921875}, {"start": 215.23, "end": 215.53, "word": " either", "probability": 0.89501953125}, {"start": 215.53, "end": 215.71, "word": " in", "probability": 0.93408203125}, {"start": 215.71, "end": 215.83, "word": " the", "probability": 0.923828125}, {"start": 215.83, "end": 216.13, "word": " middle", "probability": 0.9453125}, {"start": 216.13, "end": 216.63, "word": " or", "probability": 0.947265625}, {"start": 216.63, "end": 217.01, "word": " in", "probability": 0.92919921875}, {"start": 217.01, "end": 217.25, "word": " the", "probability": 0.9208984375}, {"start": 217.25, "end": 217.55, "word": " end.", "probability": 0.90576171875}, {"start": 220.01, "end": 220.71, "word": " And", "probability": 0.363525390625}, {"start": 220.71, "end": 223.29, "word": " also", "probability": 0.841796875}, {"start": 223.29, "end": 223.51, "word": " we", "probability": 0.826171875}, {"start": 223.51, "end": 223.89, "word": " have", "probability": 0.95068359375}], "temperature": 1.0}, {"id": 9, "seek": 24894, "start": 224.82, "end": 248.94, "text": " Nahr, still we have many other words in Arabic that contain only two clusters. However, English has seven clusters. Some other languages have more clusters than English, like Baba. We have sixteen clusters in Baba. Okay? So, you know, this differs from one language to another.", "tokens": [426, 5398, 11, 920, 321, 362, 867, 661, 2283, 294, 19938, 300, 5304, 787, 732, 23313, 13, 2908, 11, 3669, 575, 3407, 23313, 13, 2188, 661, 8650, 362, 544, 23313, 813, 3669, 11, 411, 22529, 13, 492, 362, 27847, 23313, 294, 22529, 13, 1033, 30, 407, 11, 291, 458, 11, 341, 37761, 490, 472, 2856, 281, 1071, 13], "avg_logprob": -0.1814088962845883, "compression_ratio": 1.5617977528089888, "no_speech_prob": 0.0, "words": [{"start": 224.82, "end": 225.28, "word": " Nahr,", "probability": 0.545074462890625}, {"start": 225.64, "end": 225.98, "word": " still", "probability": 0.80712890625}, {"start": 225.98, "end": 226.16, "word": " we", "probability": 0.76416015625}, {"start": 226.16, "end": 226.38, "word": " have", "probability": 0.95068359375}, {"start": 226.38, "end": 226.64, "word": " many", "probability": 0.89794921875}, {"start": 226.64, "end": 226.94, "word": " other", "probability": 0.86962890625}, {"start": 226.94, "end": 227.18, "word": " words", "probability": 0.84521484375}, {"start": 227.18, "end": 227.34, "word": " in", "probability": 0.94287109375}, {"start": 227.34, "end": 227.62, "word": " Arabic", "probability": 0.931640625}, {"start": 227.62, "end": 227.88, "word": " that", "probability": 0.78515625}, {"start": 227.88, "end": 228.32, "word": " contain", "probability": 0.8798828125}, {"start": 228.32, "end": 228.68, "word": " only", "probability": 0.91796875}, {"start": 228.68, "end": 229.1, "word": " two", "probability": 0.9013671875}, {"start": 229.1, "end": 229.92, "word": " clusters.", "probability": 0.931640625}, {"start": 230.46, "end": 230.86, "word": " However,", "probability": 0.86572265625}, {"start": 231.36, "end": 231.64, "word": " English", "probability": 0.97802734375}, {"start": 231.64, "end": 232.04, "word": " has", "probability": 0.94970703125}, {"start": 232.04, "end": 232.4, "word": " seven", "probability": 0.8681640625}, {"start": 232.4, "end": 232.88, "word": " clusters.", "probability": 0.9365234375}, {"start": 233.54, "end": 233.74, "word": " Some", "probability": 0.87939453125}, {"start": 233.74, "end": 234.08, "word": " other", "probability": 0.89306640625}, {"start": 234.08, "end": 234.5, "word": " languages", "probability": 0.96435546875}, {"start": 234.5, "end": 235.32, "word": " have", "probability": 0.94921875}, {"start": 235.32, "end": 235.74, "word": " more", "probability": 0.93603515625}, {"start": 235.74, "end": 236.34, "word": " clusters", "probability": 0.92236328125}, {"start": 236.34, "end": 236.68, "word": " than", "probability": 0.94970703125}, {"start": 236.68, "end": 237.12, "word": " English,", "probability": 0.97998046875}, {"start": 237.22, "end": 237.5, "word": " like", "probability": 0.94580078125}, {"start": 237.5, "end": 237.94, "word": " Baba.", "probability": 0.5341796875}, {"start": 238.44, "end": 238.66, "word": " We", "probability": 0.96923828125}, {"start": 238.66, "end": 239.04, "word": " have", "probability": 0.94873046875}, {"start": 239.04, "end": 239.64, "word": " sixteen", "probability": 0.51416015625}, {"start": 239.64, "end": 240.22, "word": " clusters", "probability": 0.93603515625}, {"start": 240.22, "end": 241.04, "word": " in", "probability": 0.9423828125}, {"start": 241.04, "end": 241.34, "word": " Baba.", "probability": 0.8583984375}, {"start": 242.12, "end": 242.24, "word": " Okay?", "probability": 0.498779296875}, {"start": 242.74, "end": 243.02, "word": " So,", "probability": 0.93017578125}, {"start": 243.56, "end": 243.82, "word": " you", "probability": 0.83837890625}, {"start": 243.82, "end": 244.04, "word": " know,", "probability": 0.88525390625}, {"start": 245.34, "end": 246.14, "word": " this", "probability": 0.9541015625}, {"start": 246.14, "end": 246.62, "word": " differs", "probability": 0.88623046875}, {"start": 246.62, "end": 246.96, "word": " from", "probability": 0.8876953125}, {"start": 246.96, "end": 247.2, "word": " one", "probability": 0.93408203125}, {"start": 247.2, "end": 247.76, "word": " language", "probability": 0.86279296875}, {"start": 247.76, "end": 248.6, "word": " to", "probability": 0.97314453125}, {"start": 248.6, "end": 248.94, "word": " another.", "probability": 0.92431640625}], "temperature": 1.0}, {"id": 10, "seek": 27644, "start": 250.0, "end": 276.44, "text": " Our focus will be on English and Arabic today. We are going to touch the clusterization system or consonant cluster and see how many clusters are there in English, how many clusters are there in Arabic, what are the areas of difficulties that cause interlingual errors or interlingual errors. Then we are going to shift to vowels.", "tokens": [2621, 1879, 486, 312, 322, 3669, 293, 19938, 965, 13, 492, 366, 516, 281, 2557, 264, 13630, 2144, 1185, 420, 43647, 13630, 293, 536, 577, 867, 23313, 366, 456, 294, 3669, 11, 577, 867, 23313, 366, 456, 294, 19938, 11, 437, 366, 264, 3179, 295, 14399, 300, 3082, 728, 1688, 901, 13603, 420, 560, 260, 1688, 901, 13603, 13, 1396, 321, 366, 516, 281, 5513, 281, 44972, 13], "avg_logprob": -0.13247283126996912, "compression_ratio": 1.7700534759358288, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 250.0, "end": 250.78, "word": " Our", "probability": 0.487060546875}, {"start": 250.78, "end": 251.22, "word": " focus", "probability": 0.95654296875}, {"start": 251.22, "end": 251.46, "word": " will", "probability": 0.8603515625}, {"start": 251.46, "end": 251.72, "word": " be", "probability": 0.95849609375}, {"start": 251.72, "end": 252.14, "word": " on", "probability": 0.92578125}, {"start": 252.14, "end": 253.28, "word": " 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Okay? Let's see.", "tokens": [281, 536, 264, 2099, 44972, 11, 264, 938, 44972, 11, 264, 10460, 357, 71, 42478, 11, 293, 536, 611, 3179, 295, 14399, 294, 23338, 11, 293, 264, 7700, 295, 264, 732, 3467, 295, 13603, 11, 264, 728, 1688, 901, 293, 264, 43358, 1688, 901, 13, 1033, 30, 961, 311, 536, 13], "avg_logprob": -0.16045673764668977, "compression_ratio": 1.5217391304347827, "no_speech_prob": 0.0, "words": [{"start": 277.46, "end": 277.68, "word": " to", "probability": 0.54736328125}, {"start": 277.68, "end": 277.86, "word": " see", "probability": 0.92041015625}, {"start": 277.86, "end": 278.06, "word": " the", "probability": 0.85888671875}, {"start": 278.06, "end": 278.38, "word": " short", "probability": 0.9677734375}, {"start": 278.38, "end": 278.9, "word": " vowels,", "probability": 0.9736328125}, {"start": 279.56, "end": 279.68, "word": " the", "probability": 0.87451171875}, {"start": 279.68, "end": 279.98, "word": " long", "probability": 0.92919921875}, {"start": 279.98, "end": 280.54, "word": " vowels,", "probability": 0.98486328125}, {"start": 281.24, "end": 281.36, "word": " the", "probability": 0.841796875}, {"start": 281.36, "end": 281.84, "word": " diphthongs,", "probability": 0.9051513671875}, {"start": 282.38, "end": 282.66, "word": " and", "probability": 0.9189453125}, {"start": 282.66, "end": 282.86, "word": " see", "probability": 0.77783203125}, {"start": 282.86, "end": 283.28, "word": " also", "probability": 0.767578125}, {"start": 283.28, "end": 283.62, "word": " areas", "probability": 0.92724609375}, {"start": 283.62, "end": 283.84, "word": " of", "probability": 0.966796875}, {"start": 283.84, "end": 284.34, "word": " difficulties", "probability": 0.7861328125}, {"start": 284.34, "end": 284.68, "word": " in", "probability": 0.9384765625}, {"start": 284.68, "end": 285.26, "word": " pronunciation,", "probability": 0.943359375}, {"start": 286.3, "end": 287.46, "word": " and", "probability": 0.935546875}, {"start": 287.46, "end": 288.18, "word": " the", "probability": 0.912109375}, {"start": 288.18, "end": 288.5, "word": " causes", "probability": 0.88330078125}, {"start": 288.5, "end": 289.38, "word": " of", "probability": 0.9658203125}, {"start": 289.38, "end": 290.5, "word": " the", "probability": 0.76171875}, {"start": 290.5, "end": 291.26, "word": " two", "probability": 0.94287109375}, {"start": 291.26, "end": 291.64, "word": " types", "probability": 0.783203125}, {"start": 291.64, "end": 291.86, "word": " of", "probability": 0.970703125}, {"start": 291.86, "end": 292.92, "word": " errors,", "probability": 0.8427734375}, {"start": 293.1, "end": 293.22, "word": " the", "probability": 0.916015625}, {"start": 293.22, "end": 293.84, "word": " interlingual", "probability": 0.927734375}, {"start": 293.84, "end": 294.46, "word": " and", "probability": 0.91455078125}, {"start": 294.46, "end": 294.62, "word": " the", "probability": 0.8876953125}, {"start": 294.62, "end": 295.26, "word": " intralingual.", "probability": 0.7840169270833334}, {"start": 295.68, "end": 295.98, "word": " Okay?", "probability": 0.65380859375}, {"start": 297.42, "end": 297.8, "word": " Let's", "probability": 0.964599609375}, {"start": 297.8, "end": 298.04, "word": " see.", "probability": 0.92431640625}], "temperature": 1.0}, {"id": 12, "seek": 33967, "start": 311.07, "end": 339.67, "text": " For the clusters of English, I mentioned that we have two clusters or more, either three or four, up to seven. So look to the two clusters. We have sphere, sleeve, cats, dogs. So you have two clusters, meaning two consonants at the end of a word, like dogs, cats,", "tokens": [1171, 264, 23313, 295, 3669, 11, 286, 2835, 300, 321, 362, 732, 23313, 420, 544, 11, 2139, 1045, 420, 1451, 11, 493, 281, 3407, 13, 407, 574, 281, 264, 732, 23313, 13, 492, 362, 16687, 11, 21138, 11, 11111, 11, 7197, 13, 407, 291, 362, 732, 23313, 11, 3620, 732, 30843, 1719, 412, 264, 917, 295, 257, 1349, 11, 411, 7197, 11, 11111, 11], "avg_logprob": -0.1441105769230769, "compression_ratio": 1.6296296296296295, "no_speech_prob": 0.0, "words": [{"start": 311.07, "end": 311.37, "word": " For", "probability": 0.87841796875}, {"start": 311.37, "end": 311.53, "word": " the", "probability": 0.9111328125}, {"start": 311.53, "end": 311.87, "word": " clusters", "probability": 0.9287109375}, {"start": 311.87, "end": 312.19, "word": " of", "probability": 0.9697265625}, {"start": 312.19, "end": 313.03, "word": " English,", "probability": 0.951171875}, {"start": 313.79, "end": 314.13, "word": " I", "probability": 0.99609375}, {"start": 314.13, "end": 314.45, "word": " mentioned", "probability": 0.77490234375}, {"start": 314.45, "end": 314.71, "word": " that", "probability": 0.9375}, {"start": 314.71, "end": 314.91, "word": " we", "probability": 0.96337890625}, {"start": 314.91, "end": 315.23, "word": " have", "probability": 0.95068359375}, {"start": 315.23, "end": 317.13, "word": " two", "probability": 0.87890625}, {"start": 317.13, "end": 317.63, "word": " clusters", "probability": 0.93798828125}, {"start": 317.63, "end": 320.13, "word": " or", "probability": 0.79541015625}, {"start": 320.13, "end": 320.53, "word": " more,", "probability": 0.9423828125}, {"start": 320.79, "end": 321.03, "word": " either", "probability": 0.91845703125}, {"start": 321.03, "end": 321.53, "word": " three", "probability": 0.869140625}, {"start": 321.53, "end": 321.85, "word": " or", "probability": 0.79052734375}, {"start": 321.85, "end": 322.37, "word": " four,", "probability": 0.93212890625}, {"start": 322.45, "end": 322.65, "word": " up", "probability": 0.955078125}, {"start": 322.65, "end": 322.79, "word": " to", "probability": 0.97412109375}, {"start": 322.79, "end": 323.11, "word": " seven.", "probability": 0.90625}, {"start": 323.81, "end": 324.25, "word": " So", "probability": 0.9091796875}, {"start": 324.25, "end": 325.19, "word": " look", "probability": 0.76123046875}, {"start": 325.19, "end": 325.35, "word": " to", "probability": 0.94384765625}, {"start": 325.35, "end": 325.61, "word": " the", "probability": 0.9033203125}, {"start": 325.61, "end": 326.05, "word": " two", "probability": 0.89599609375}, {"start": 326.05, "end": 326.47, "word": " clusters.", "probability": 0.93603515625}, {"start": 326.69, "end": 326.77, "word": " We", "probability": 0.96337890625}, {"start": 326.77, "end": 327.59, "word": " have", "probability": 0.9453125}, {"start": 327.59, "end": 328.15, "word": " sphere,", "probability": 0.703125}, {"start": 329.09, "end": 329.45, "word": " sleeve,", "probability": 0.689453125}, {"start": 330.57, "end": 330.91, "word": " cats,", "probability": 0.50341796875}, {"start": 331.83, "end": 332.19, "word": " dogs.", "probability": 0.8779296875}, {"start": 332.79, "end": 333.17, "word": " So", "probability": 0.94873046875}, {"start": 333.17, "end": 333.27, "word": " you", "probability": 0.919921875}, {"start": 333.27, "end": 333.41, "word": " have", "probability": 0.94287109375}, {"start": 333.41, "end": 333.63, "word": " two", "probability": 0.9423828125}, {"start": 333.63, "end": 334.05, "word": " clusters,", "probability": 0.9140625}, {"start": 334.65, "end": 334.89, "word": " meaning", "probability": 0.38720703125}, {"start": 334.89, "end": 335.19, "word": " two", "probability": 0.92041015625}, {"start": 335.19, "end": 335.87, "word": " consonants", "probability": 0.9775390625}, {"start": 335.87, "end": 336.51, "word": " at", "probability": 0.7216796875}, {"start": 336.51, "end": 336.65, "word": " the", "probability": 0.9228515625}, {"start": 336.65, "end": 336.79, "word": " end", "probability": 0.904296875}, {"start": 336.79, "end": 336.91, "word": " of", "probability": 0.9697265625}, {"start": 336.91, "end": 337.07, "word": " a", "probability": 0.94287109375}, {"start": 337.07, "end": 337.29, "word": " word,", "probability": 0.94482421875}, {"start": 337.39, "end": 337.61, "word": " like", "probability": 0.94384765625}, {"start": 337.61, "end": 338.01, "word": " dogs,", "probability": 0.8291015625}, {"start": 339.25, "end": 339.67, "word": " cats,", "probability": 0.93896484375}], "temperature": 1.0}, {"id": 13, "seek": 36593, "start": 340.43, "end": 365.93, "text": " The beginning as sleep, sphere. We have three consonants. This is street, risk, blanched, fix, this. We have five clusters as in mixed, mixed sweets. Two words.", "tokens": [440, 2863, 382, 2817, 11, 16687, 13, 492, 362, 1045, 30843, 1719, 13, 639, 307, 4838, 11, 3148, 11, 888, 4778, 292, 11, 3191, 11, 341, 13, 492, 362, 1732, 23313, 382, 294, 7467, 11, 7467, 28680, 13, 4453, 2283, 13], "avg_logprob": -0.20833333830038706, "compression_ratio": 1.3305785123966942, "no_speech_prob": 0.0, "words": [{"start": 340.43, "end": 340.71, "word": " The", "probability": 0.7646484375}, {"start": 340.71, "end": 341.17, "word": " beginning", "probability": 0.92724609375}, {"start": 341.17, "end": 341.81, "word": " as", "probability": 0.4892578125}, {"start": 341.81, "end": 342.33, "word": " sleep,", "probability": 0.453125}, {"start": 343.05, "end": 343.67, "word": " sphere.", "probability": 0.923828125}, {"start": 344.11, "end": 344.49, "word": " We", "probability": 0.96630859375}, {"start": 344.49, "end": 344.65, "word": " have", "probability": 0.94970703125}, {"start": 344.65, "end": 344.93, "word": " three", "probability": 0.9150390625}, {"start": 344.93, "end": 345.57, "word": " consonants.", "probability": 0.98291015625}, {"start": 346.67, "end": 346.85, "word": " This", "probability": 0.89306640625}, {"start": 346.85, "end": 347.27, "word": " is", "probability": 0.95849609375}, {"start": 347.27, "end": 348.03, "word": " street,", "probability": 0.79150390625}, {"start": 349.69, "end": 350.05, "word": " risk,", "probability": 0.70361328125}, {"start": 351.49, "end": 352.27, "word": " blanched,", "probability": 0.7438151041666666}, {"start": 353.11, "end": 353.47, "word": " fix,", "probability": 0.74072265625}, {"start": 354.81, "end": 355.15, "word": " this.", "probability": 0.966796875}, {"start": 357.45, "end": 358.49, "word": " We", "probability": 0.9638671875}, {"start": 358.49, "end": 358.69, "word": " have", "probability": 0.95068359375}, {"start": 358.69, "end": 358.99, "word": " five", "probability": 0.9130859375}, {"start": 358.99, "end": 359.45, "word": " clusters", "probability": 0.93359375}, {"start": 359.45, "end": 360.63, "word": " as", "probability": 0.7138671875}, {"start": 360.63, "end": 360.79, "word": " in", "probability": 0.94189453125}, {"start": 360.79, "end": 361.17, "word": " mixed,", "probability": 0.8857421875}, {"start": 362.13, "end": 363.03, "word": " mixed", "probability": 0.923828125}, {"start": 363.03, "end": 363.55, "word": " sweets.", "probability": 0.93603515625}, {"start": 364.95, "end": 365.55, "word": " Two", "probability": 0.88330078125}, {"start": 365.55, "end": 365.93, "word": " words.", "probability": 0.87353515625}], "temperature": 1.0}, {"id": 14, "seek": 39326, "start": 367.72, "end": 393.26, "text": " Six consonants as first stream. Seven consonants as term stranger or term strangers. Here we have the mistake committed by the Arab students. This is by inserting a vowel, fracturing the clusterization system.", "tokens": [11678, 30843, 1719, 382, 700, 4309, 13, 14868, 30843, 1719, 382, 1433, 18834, 420, 1433, 22724, 13, 1692, 321, 362, 264, 6146, 7784, 538, 264, 8625, 1731, 13, 639, 307, 538, 46567, 257, 29410, 11, 17948, 1345, 264, 13630, 2144, 1185, 13], "avg_logprob": -0.14925509275392043, "compression_ratio": 1.4893617021276595, "no_speech_prob": 0.0, "words": [{"start": 367.72, "end": 368.18, "word": " Six", "probability": 0.580078125}, {"start": 368.18, "end": 369.58, "word": " consonants", "probability": 0.979248046875}, {"start": 369.58, "end": 370.1, "word": " as", "probability": 0.94970703125}, {"start": 370.1, "end": 370.66, "word": " first", "probability": 0.802734375}, {"start": 370.66, "end": 371.16, "word": " stream.", "probability": 0.951171875}, {"start": 373.18, "end": 373.64, "word": " Seven", "probability": 0.80517578125}, {"start": 373.64, "end": 374.36, "word": " consonants", "probability": 0.96923828125}, {"start": 374.36, "end": 374.82, "word": " as", "probability": 0.9638671875}, {"start": 374.82, "end": 375.1, "word": " term", "probability": 0.39501953125}, {"start": 375.1, "end": 375.68, "word": " stranger", "probability": 0.8671875}, {"start": 375.68, "end": 378.18, "word": " or", "probability": 0.59521484375}, {"start": 378.18, "end": 378.48, "word": " term", "probability": 0.74658203125}, {"start": 378.48, "end": 379.38, "word": " strangers.", "probability": 0.8486328125}, {"start": 380.48, "end": 381.0, "word": " Here", "probability": 0.86376953125}, {"start": 381.0, "end": 381.18, "word": " we", "probability": 0.75439453125}, {"start": 381.18, "end": 381.62, "word": " have", "probability": 0.95068359375}, {"start": 381.62, "end": 382.5, "word": " the", "probability": 0.91162109375}, {"start": 382.5, "end": 382.88, "word": " mistake", "probability": 0.955078125}, {"start": 382.88, "end": 383.32, "word": " committed", "probability": 0.947265625}, {"start": 383.32, "end": 383.7, "word": " by", "probability": 0.970703125}, {"start": 383.7, "end": 383.9, "word": " the", "probability": 0.9208984375}, {"start": 383.9, "end": 384.14, "word": " Arab", "probability": 0.73681640625}, {"start": 384.14, "end": 384.7, "word": " students.", "probability": 0.96923828125}, {"start": 385.22, "end": 385.76, "word": " This", "probability": 0.90380859375}, {"start": 385.76, "end": 385.92, "word": " is", "probability": 0.94482421875}, {"start": 385.92, "end": 386.24, "word": " by", "probability": 0.96826171875}, {"start": 386.24, "end": 387.02, "word": " inserting", "probability": 0.8408203125}, {"start": 387.02, "end": 388.2, "word": " a", "probability": 0.99462890625}, {"start": 388.2, "end": 388.54, "word": " vowel,", "probability": 0.97509765625}, {"start": 391.02, "end": 391.68, "word": " fracturing", "probability": 0.951171875}, {"start": 391.68, "end": 391.98, "word": " the", "probability": 0.92431640625}, {"start": 391.98, "end": 392.76, "word": " clusterization", "probability": 0.911865234375}, {"start": 392.76, "end": 393.26, "word": " system.", "probability": 0.9541015625}], "temperature": 1.0}, {"id": 15, "seek": 42117, "start": 396.85, "end": 421.17, "text": " So instead of saying sphere, you may find your students say a sphere. They add the Hamza, the glottal sound, which is not found in English. Instead of saying, for example, dogs, they fracture the clusterization system by inserting a vowel in between. This vowel is originally Arabic.", "tokens": [407, 2602, 295, 1566, 16687, 11, 291, 815, 915, 428, 1731, 584, 257, 16687, 13, 814, 909, 264, 8234, 2394, 11, 264, 1563, 1521, 304, 1626, 11, 597, 307, 406, 1352, 294, 3669, 13, 7156, 295, 1566, 11, 337, 1365, 11, 7197, 11, 436, 36877, 264, 13630, 2144, 1185, 538, 46567, 257, 29410, 294, 1296, 13, 639, 29410, 307, 7993, 19938, 13], "avg_logprob": -0.14781746599409315, "compression_ratio": 1.4947368421052631, "no_speech_prob": 0.0, "words": [{"start": 396.85, "end": 397.21, "word": " So", "probability": 0.78955078125}, {"start": 397.21, "end": 397.59, "word": " instead", "probability": 0.6787109375}, {"start": 397.59, "end": 397.79, "word": " of", "probability": 0.97314453125}, {"start": 397.79, "end": 398.27, "word": " saying", "probability": 0.916015625}, {"start": 398.27, "end": 399.65, "word": " sphere,", "probability": 0.61962890625}, {"start": 400.45, "end": 400.91, "word": " you", "probability": 0.9599609375}, {"start": 400.91, "end": 401.11, "word": " may", "probability": 0.94482421875}, {"start": 401.11, "end": 401.45, "word": " find", "probability": 0.8740234375}, {"start": 401.45, "end": 401.65, "word": " your", "probability": 0.79931640625}, {"start": 401.65, "end": 401.99, "word": " students", "probability": 0.927734375}, {"start": 401.99, "end": 402.35, "word": " say", "probability": 0.92578125}, {"start": 402.35, "end": 402.55, "word": " a", "probability": 0.408935546875}, {"start": 402.55, "end": 402.93, "word": " sphere.", "probability": 0.93408203125}, {"start": 403.27, "end": 403.59, "word": " They", "probability": 0.80224609375}, {"start": 403.59, "end": 403.99, "word": " add", "probability": 0.90380859375}, {"start": 403.99, "end": 404.49, "word": " the", "probability": 0.89453125}, {"start": 404.49, "end": 405.07, "word": " Hamza,", "probability": 0.822265625}, {"start": 405.19, "end": 405.31, "word": " the", "probability": 0.845703125}, {"start": 405.31, "end": 405.71, "word": " glottal", "probability": 0.8463541666666666}, {"start": 405.71, "end": 406.09, "word": " sound,", "probability": 0.873046875}, {"start": 406.21, "end": 406.29, "word": " which", "probability": 0.94677734375}, {"start": 406.29, "end": 406.47, "word": " is", "probability": 0.94384765625}, {"start": 406.47, "end": 406.65, "word": " not", "probability": 0.94921875}, {"start": 406.65, "end": 406.97, "word": " found", "probability": 0.9150390625}, {"start": 406.97, "end": 407.15, "word": " in", "probability": 0.95166015625}, {"start": 407.15, "end": 407.55, "word": " English.", "probability": 0.978515625}, {"start": 410.77, "end": 411.47, "word": " Instead", "probability": 0.5126953125}, {"start": 411.47, "end": 411.89, "word": " of", "probability": 0.970703125}, {"start": 411.89, "end": 412.59, "word": " saying,", "probability": 0.90966796875}, {"start": 412.69, "end": 412.77, "word": " for", "probability": 0.95751953125}, {"start": 412.77, "end": 413.25, "word": " example,", "probability": 0.97216796875}, {"start": 413.55, "end": 413.93, "word": " dogs,", "probability": 0.83447265625}, {"start": 414.67, "end": 414.87, "word": " they", "probability": 0.89208984375}, {"start": 414.87, "end": 415.41, "word": " fracture", "probability": 0.83837890625}, {"start": 415.41, "end": 415.65, "word": " the", "probability": 0.89599609375}, {"start": 415.65, "end": 416.33, "word": " clusterization", "probability": 0.8017578125}, {"start": 416.33, "end": 416.83, "word": " system", "probability": 0.95263671875}, {"start": 416.83, "end": 417.07, "word": " by", "probability": 0.9697265625}, {"start": 417.07, "end": 417.63, "word": " inserting", "probability": 0.82080078125}, {"start": 417.63, "end": 417.91, "word": " a", "probability": 0.9970703125}, {"start": 417.91, "end": 418.17, "word": " vowel", "probability": 0.9833984375}, {"start": 418.17, "end": 418.95, "word": " in", "probability": 0.9443359375}, {"start": 418.95, "end": 419.29, "word": " between.", "probability": 0.8427734375}, {"start": 419.43, "end": 419.61, "word": " This", "probability": 0.9033203125}, {"start": 419.61, "end": 419.97, "word": " vowel", "probability": 0.974609375}, {"start": 419.97, "end": 420.27, "word": " is", "probability": 0.9423828125}, {"start": 420.27, "end": 420.77, "word": " originally", "probability": 0.7890625}, {"start": 420.77, "end": 421.17, "word": " Arabic.", "probability": 0.87841796875}], "temperature": 1.0}, {"id": 16, "seek": 44186, "start": 421.82, "end": 441.86, "text": " Either nominative, accusative, or genitive. Transferred into English. So instead of saying, for example, dogs, they say doggies. Mixed, they say mixed. Question, they say a question.", "tokens": [13746, 5369, 259, 1166, 11, 11168, 1166, 11, 420, 1049, 2187, 13, 6531, 612, 986, 666, 3669, 13, 407, 2602, 295, 1566, 11, 337, 1365, 11, 7197, 11, 436, 584, 360, 1615, 530, 13, 12769, 292, 11, 436, 584, 7467, 13, 14464, 11, 436, 584, 257, 1168, 13], "avg_logprob": -0.2696109791191257, "compression_ratio": 1.4186046511627908, "no_speech_prob": 0.0, "words": [{"start": 421.82, "end": 422.26, "word": " Either", "probability": 0.298583984375}, {"start": 422.26, "end": 423.36, "word": " nominative,", "probability": 0.84765625}, {"start": 423.52, "end": 424.18, "word": " accusative,", "probability": 0.947021484375}, {"start": 424.32, "end": 424.46, "word": " or", "probability": 0.95458984375}, {"start": 424.46, "end": 424.94, "word": " genitive.", "probability": 0.90234375}, {"start": 426.96, "end": 427.52, "word": " Transferred", "probability": 0.71728515625}, {"start": 427.52, "end": 427.68, "word": " into", "probability": 0.83447265625}, {"start": 427.68, "end": 428.22, "word": " English.", "probability": 0.970703125}, {"start": 428.7, "end": 428.84, "word": " So", "probability": 0.85986328125}, {"start": 428.84, "end": 429.12, "word": " instead", "probability": 0.7255859375}, {"start": 429.12, "end": 429.24, "word": " of", "probability": 0.96728515625}, {"start": 429.24, "end": 429.48, "word": " saying,", "probability": 0.9072265625}, {"start": 429.54, "end": 429.6, "word": " for", "probability": 0.93505859375}, {"start": 429.6, "end": 430.06, "word": " example,", "probability": 0.9716796875}, {"start": 430.24, "end": 430.6, "word": " dogs,", "probability": 0.6259765625}, {"start": 431.16, "end": 431.36, "word": " they", "probability": 0.890625}, {"start": 431.36, "end": 431.62, "word": " say", "probability": 0.94287109375}, {"start": 431.62, "end": 432.18, "word": " doggies.", "probability": 0.5714518229166666}, {"start": 435.18, "end": 435.74, "word": " Mixed,", "probability": 0.709716796875}, {"start": 435.88, "end": 436.1, "word": " they", "probability": 0.8935546875}, {"start": 436.1, "end": 436.34, "word": " say", "probability": 0.9404296875}, {"start": 436.34, "end": 436.68, "word": " mixed.", "probability": 0.83740234375}, {"start": 439.92, "end": 440.48, "word": " Question,", "probability": 0.72509765625}, {"start": 440.86, "end": 441.06, "word": " they", "probability": 0.88818359375}, {"start": 441.06, "end": 441.28, "word": " say", "probability": 0.943359375}, {"start": 441.28, "end": 441.46, "word": " a", "probability": 0.7412109375}, {"start": 441.46, "end": 441.86, "word": " question.", "probability": 0.9345703125}], "temperature": 1.0}, {"id": 17, "seek": 46993, "start": 443.17, "end": 469.93, "text": " And the Egyptians say, question, street, they street. And we say, street, or street. So they fracture the clusterization system mainly because of the effect of their mother tongue that is Arabic. You see that? Okay. Now we have", "tokens": [400, 264, 44119, 584, 11, 1168, 11, 4838, 11, 436, 4838, 13, 400, 321, 584, 11, 4838, 11, 420, 4838, 13, 407, 436, 36877, 264, 13630, 2144, 1185, 8704, 570, 295, 264, 1802, 295, 641, 2895, 10601, 300, 307, 19938, 13, 509, 536, 300, 30, 1033, 13, 823, 321, 362], "avg_logprob": -0.27558210433698166, "compression_ratio": 1.4805194805194806, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 443.17, "end": 443.47, "word": " And", "probability": 0.61474609375}, {"start": 443.47, "end": 443.61, "word": " the", "probability": 0.859375}, {"start": 443.61, "end": 444.07, "word": " Egyptians", "probability": 0.95263671875}, {"start": 444.07, "end": 444.91, "word": " say,", "probability": 0.89453125}, {"start": 444.99, "end": 445.39, "word": " question,", "probability": 0.3974609375}, {"start": 446.39, "end": 446.91, "word": " street,", "probability": 0.83642578125}, {"start": 447.67, "end": 447.81, "word": " they", "probability": 0.51806640625}, {"start": 447.81, "end": 448.15, "word": " street.", "probability": 0.5576171875}, {"start": 449.01, "end": 449.37, "word": " And", "probability": 0.94482421875}, {"start": 449.37, "end": 449.71, "word": " we", "probability": 0.9560546875}, {"start": 449.71, "end": 450.71, "word": " say,", "probability": 0.92822265625}, {"start": 450.97, "end": 451.31, "word": " street,", "probability": 0.73388671875}, {"start": 452.05, "end": 452.41, "word": " or", "probability": 0.916015625}, {"start": 452.41, "end": 452.87, "word": " street.", "probability": 0.2159423828125}, {"start": 453.67, "end": 454.03, "word": " So", "probability": 0.955078125}, {"start": 454.03, "end": 454.23, "word": " they", "probability": 0.7880859375}, {"start": 454.23, "end": 454.69, "word": " fracture", "probability": 0.775390625}, {"start": 454.69, "end": 455.33, "word": " the", "probability": 0.8984375}, {"start": 455.33, "end": 456.11, "word": " clusterization", "probability": 0.8125}, {"start": 456.11, "end": 456.67, "word": " system", "probability": 0.94677734375}, {"start": 456.67, "end": 457.55, "word": " mainly", "probability": 0.7900390625}, {"start": 457.55, "end": 458.99, "word": " because", "probability": 0.8916015625}, {"start": 458.99, "end": 459.89, "word": " of", "probability": 0.96875}, {"start": 459.89, "end": 460.09, "word": " the", "probability": 0.91796875}, {"start": 460.09, "end": 460.53, "word": " effect", "probability": 0.8857421875}, {"start": 460.53, "end": 460.93, "word": " of", "probability": 0.96826171875}, {"start": 460.93, "end": 461.15, "word": " their", "probability": 0.9453125}, {"start": 461.15, "end": 461.39, "word": " mother", "probability": 0.87158203125}, {"start": 461.39, "end": 461.77, "word": " tongue", "probability": 0.92041015625}, {"start": 461.77, "end": 462.17, "word": " that", "probability": 0.75830078125}, {"start": 462.17, "end": 462.41, "word": " is", "probability": 0.95166015625}, {"start": 462.41, "end": 462.75, "word": " Arabic.", "probability": 0.88232421875}, {"start": 464.89, "end": 465.15, "word": " You", "probability": 0.92041015625}, {"start": 465.15, "end": 465.31, "word": " see", "probability": 0.92724609375}, {"start": 465.31, "end": 465.59, "word": " that?", "probability": 0.93115234375}, {"start": 467.49, "end": 468.29, "word": " Okay.", "probability": 0.607421875}, {"start": 469.01, "end": 469.39, "word": " Now", "probability": 0.9619140625}, {"start": 469.39, "end": 469.57, "word": " we", "probability": 0.79931640625}, {"start": 469.57, "end": 469.93, "word": " have", "probability": 0.9501953125}], "temperature": 1.0}, {"id": 18, "seek": 49758, "start": 472.16, "end": 497.58, "text": " More details about consonant clusters. Okay? We have the s sound followed by either p, t, k, f, m, l, w, y, as in spear, steam. So we have two clusters.", "tokens": [5048, 4365, 466, 43647, 23313, 13, 1033, 30, 492, 362, 264, 262, 1626, 6263, 538, 2139, 280, 11, 256, 11, 350, 11, 283, 11, 275, 11, 287, 11, 261, 11, 288, 11, 382, 294, 26993, 11, 11952, 13, 407, 321, 362, 732, 23313, 13], "avg_logprob": -0.16909722487131754, "compression_ratio": 1.2857142857142858, "no_speech_prob": 0.0, "words": [{"start": 472.16, "end": 472.5, "word": " More", "probability": 0.65625}, {"start": 472.5, "end": 473.0, "word": " details", "probability": 0.87744140625}, {"start": 473.0, "end": 473.64, "word": " about", "probability": 0.908203125}, {"start": 473.64, "end": 474.48, "word": " consonant", "probability": 0.92236328125}, {"start": 474.48, "end": 475.02, "word": " clusters.", "probability": 0.93505859375}, {"start": 476.2, "end": 476.38, "word": " Okay?", "probability": 0.611328125}, {"start": 478.84, "end": 479.56, "word": " We", "probability": 0.9560546875}, {"start": 479.56, "end": 480.04, "word": " have", "probability": 0.955078125}, {"start": 480.04, "end": 480.92, "word": " the", "probability": 0.89404296875}, {"start": 480.92, "end": 481.54, "word": " s", "probability": 0.2271728515625}, {"start": 481.54, "end": 482.36, "word": " sound", "probability": 0.74951171875}, {"start": 482.36, "end": 483.44, "word": " followed", "probability": 0.79345703125}, {"start": 483.44, "end": 483.86, "word": " by", "probability": 0.96337890625}, {"start": 483.86, "end": 485.02, "word": " either", "probability": 0.94775390625}, {"start": 485.02, "end": 485.26, "word": " p,", "probability": 0.414306640625}, {"start": 485.74, "end": 486.48, "word": " t,", "probability": 0.97119140625}, {"start": 487.04, "end": 487.56, "word": " k,", "probability": 0.97998046875}, {"start": 487.94, "end": 488.08, "word": " f,", "probability": 0.8916015625}, {"start": 488.84, "end": 488.94, "word": " m,", "probability": 0.9951171875}, {"start": 489.16, "end": 490.34, "word": " l,", "probability": 0.9775390625}, {"start": 490.44, "end": 491.38, "word": " w,", "probability": 0.91455078125}, {"start": 491.62, "end": 492.1, "word": " y,", "probability": 0.78369140625}, {"start": 492.36, "end": 493.34, "word": " as", "probability": 0.93310546875}, {"start": 493.34, "end": 493.56, "word": " in", "probability": 0.939453125}, {"start": 493.56, "end": 494.04, "word": " spear,", "probability": 0.79052734375}, {"start": 495.3, "end": 495.76, "word": " steam.", "probability": 0.9345703125}, {"start": 496.16, "end": 496.58, "word": " So", "probability": 0.953125}, {"start": 496.58, "end": 496.72, "word": " we", "probability": 0.6611328125}, {"start": 496.72, "end": 496.94, "word": " have", "probability": 0.94873046875}, {"start": 496.94, "end": 497.2, "word": " two", "probability": 0.92529296875}, {"start": 497.2, "end": 497.58, "word": " clusters.", "probability": 0.92578125}], "temperature": 1.0}, {"id": 19, "seek": 52671, "start": 499.41, "end": 526.71, "text": " Sky, sphere, smile, sneer, slow, swear, and suit. Okay. So we have also the P sound followed by Ra or Wa, as in trim, twin, tune. Okay.", "tokens": [9879, 11, 16687, 11, 7563, 11, 9244, 260, 11, 2964, 11, 11902, 11, 293, 5722, 13, 1033, 13, 407, 321, 362, 611, 264, 430, 1626, 6263, 538, 7591, 420, 15405, 11, 382, 294, 10445, 11, 18397, 11, 10864, 13, 1033, 13], "avg_logprob": -0.2563244076002212, "compression_ratio": 1.2363636363636363, "no_speech_prob": 0.0, "words": [{"start": 499.41, "end": 500.13, "word": " Sky,", "probability": 0.58251953125}, {"start": 501.25, "end": 501.71, "word": " sphere,", "probability": 0.833984375}, {"start": 502.25, "end": 503.15, "word": " smile,", "probability": 0.91015625}, {"start": 503.97, "end": 504.53, "word": " sneer,", "probability": 0.931884765625}, {"start": 505.41, "end": 505.91, "word": " slow,", "probability": 0.94091796875}, {"start": 506.59, "end": 507.07, "word": " swear,", "probability": 0.250244140625}, {"start": 508.55, "end": 509.01, "word": " and", "probability": 0.85546875}, {"start": 509.01, "end": 510.79, "word": " suit.", "probability": 0.81982421875}, {"start": 511.35, "end": 512.23, "word": " Okay.", "probability": 0.76806640625}, {"start": 512.71, "end": 513.63, "word": " So", "probability": 0.94775390625}, {"start": 513.63, "end": 513.81, "word": " we", "probability": 0.814453125}, {"start": 513.81, "end": 514.03, "word": " have", "probability": 0.947265625}, {"start": 514.03, "end": 514.61, "word": " also", "probability": 0.86865234375}, {"start": 514.61, "end": 515.65, "word": " the", "probability": 0.89794921875}, {"start": 515.65, "end": 515.97, "word": " P", "probability": 0.373291015625}, {"start": 515.97, "end": 516.41, "word": " sound", "probability": 0.818359375}, {"start": 516.41, "end": 517.41, "word": " followed", "probability": 0.84228515625}, {"start": 517.41, "end": 518.23, "word": " by", "probability": 0.97998046875}, {"start": 518.23, "end": 518.79, "word": " Ra", "probability": 0.2442626953125}, {"start": 518.79, "end": 519.37, "word": " or", "probability": 0.9248046875}, {"start": 519.37, "end": 520.01, "word": " Wa,", "probability": 0.84521484375}, {"start": 520.69, "end": 520.93, "word": " as", "probability": 0.935546875}, {"start": 520.93, "end": 521.25, "word": " in", "probability": 0.9443359375}, {"start": 521.25, "end": 521.97, "word": " trim,", "probability": 0.84130859375}, {"start": 522.99, "end": 523.41, "word": " twin,", "probability": 0.97216796875}, {"start": 525.01, "end": 525.39, "word": " tune.", "probability": 0.85693359375}, {"start": 526.09, "end": 526.71, "word": " Okay.", "probability": 0.87939453125}], "temperature": 1.0}, {"id": 20, "seek": 55689, "start": 528.73, "end": 556.89, "text": " We have the K sound followed by L, R, W, Y as in clip, crime, queen, queue. The P sound followed by L, R, or Y as in flame, bright, beautiful. 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The g sound followed by l, r, as in glare, gross. The f sound followed by l, r, ya, as in flare, frame, few. This voiceless sound is followed by r, wa,", "tokens": [4151, 11, 2478, 11, 382, 294, 4016, 11, 24355, 11, 9776, 13, 440, 290, 1626, 6263, 538, 287, 11, 367, 11, 382, 294, 49159, 11, 11367, 13, 440, 283, 1626, 6263, 538, 287, 11, 367, 11, 2478, 11, 382, 294, 32446, 11, 3920, 11, 1326, 13, 639, 1650, 41817, 1626, 307, 6263, 538, 367, 11, 5406, 11], "avg_logprob": -0.19140625205533257, "compression_ratio": 1.6486486486486487, "no_speech_prob": 0.0, "words": [{"start": 557.62, "end": 558.02, "word": "wa,", "probability": 0.401611328125}, {"start": 558.42, "end": 558.6, "word": " ya,", "probability": 0.904296875}, {"start": 558.94, "end": 559.18, "word": " as", "probability": 0.96240234375}, {"start": 559.18, "end": 559.32, "word": " in", "probability": 0.94677734375}, {"start": 559.32, "end": 559.78, "word": " dry,", "probability": 0.79541015625}, {"start": 560.44, "end": 560.84, "word": " dwell,", "probability": 0.9189453125}, {"start": 561.44, "end": 561.82, "word": " duty.", "probability": 0.58056640625}, {"start": 563.02, "end": 563.34, "word": " The", "probability": 0.88916015625}, {"start": 563.34, "end": 563.74, "word": " g", "probability": 0.60009765625}, {"start": 563.74, "end": 564.44, "word": " sound", "probability": 0.78955078125}, {"start": 564.44, "end": 565.08, "word": " followed", "probability": 0.79345703125}, {"start": 565.08, "end": 565.44, "word": " by", "probability": 0.97802734375}, {"start": 565.44, "end": 565.88, "word": " l,", "probability": 0.765625}, {"start": 566.42, "end": 567.06, "word": " r,", "probability": 0.96044921875}, {"start": 567.34, "end": 567.72, "word": " as", "probability": 0.96240234375}, {"start": 567.72, "end": 567.92, "word": " in", "probability": 0.94677734375}, {"start": 567.92, "end": 568.34, "word": " glare,", "probability": 0.94287109375}, {"start": 568.96, "end": 569.32, "word": " gross.", "probability": 0.55419921875}, {"start": 570.34, "end": 570.82, "word": " The", "probability": 0.919921875}, {"start": 570.82, "end": 571.24, "word": " f", "probability": 0.7841796875}, {"start": 571.24, "end": 571.94, "word": " sound", "probability": 0.88330078125}, {"start": 571.94, "end": 572.66, "word": " followed", "probability": 0.880859375}, {"start": 572.66, "end": 573.04, "word": " by", "probability": 0.974609375}, {"start": 573.04, "end": 573.36, "word": " l,", "probability": 0.9716796875}, {"start": 573.9, "end": 574.42, "word": " r,", "probability": 0.9921875}, {"start": 574.64, "end": 575.22, "word": " ya,", "probability": 0.97705078125}, {"start": 575.5, "end": 575.76, "word": " as", "probability": 0.96875}, {"start": 575.76, "end": 576.28, "word": " in", "probability": 0.9482421875}, {"start": 576.28, "end": 576.88, "word": " flare,", "probability": 0.95068359375}, {"start": 577.68, "end": 578.14, "word": " frame,", "probability": 0.91552734375}, {"start": 578.64, "end": 578.96, "word": " few.", "probability": 0.91650390625}, {"start": 580.86, "end": 581.72, "word": " This", "probability": 0.304931640625}, {"start": 581.72, "end": 582.14, "word": " voiceless", "probability": 0.9892578125}, {"start": 582.14, "end": 582.62, "word": " sound", "probability": 0.8857421875}, {"start": 582.62, "end": 584.22, "word": " is", "probability": 0.91015625}, {"start": 584.22, "end": 584.44, "word": " followed", "probability": 0.890625}, {"start": 584.44, "end": 584.8, "word": " by", "probability": 0.97900390625}, {"start": 584.8, "end": 585.24, "word": " r,", "probability": 0.6083984375}, {"start": 585.94, "end": 586.34, "word": " wa,", "probability": 0.87060546875}], "temperature": 1.0}, {"id": 22, "seek": 61083, "start": 586.83, "end": 610.83, "text": "as in three thwot, shh followed by r sound as in shrink. Ya, m, n and ha followed by the ya sound as in mute, muse, huge. So,", "tokens": [296, 294, 1045, 258, 86, 310, 11, 402, 71, 6263, 538, 367, 1626, 382, 294, 23060, 13, 6080, 11, 275, 11, 297, 293, 324, 6263, 538, 264, 2478, 1626, 382, 294, 24523, 11, 39138, 11, 2603, 13, 407, 11], "avg_logprob": -0.38515624701976775, "compression_ratio": 1.3440860215053763, "no_speech_prob": 0.0, "words": [{"start": 586.83, "end": 587.19, "word": "as", "probability": 0.48974609375}, {"start": 587.19, "end": 587.49, "word": " in", "probability": 0.94921875}, {"start": 587.49, "end": 588.07, "word": " three", "probability": 0.72119140625}, {"start": 588.07, "end": 590.37, "word": " thwot,", "probability": 0.3869222005208333}, {"start": 590.83, "end": 592.35, "word": " shh", "probability": 0.4632568359375}, {"start": 592.35, "end": 593.03, "word": " followed", "probability": 0.4423828125}, {"start": 593.03, "end": 593.53, "word": " by", "probability": 0.98046875}, {"start": 593.53, "end": 594.13, "word": " r", "probability": 0.349853515625}, {"start": 594.13, "end": 594.73, "word": " sound", "probability": 0.5615234375}, {"start": 594.73, "end": 595.13, "word": " as", "probability": 0.837890625}, {"start": 595.13, "end": 595.31, "word": " in", "probability": 0.94384765625}, {"start": 595.31, "end": 595.87, "word": " shrink.", "probability": 0.861328125}, {"start": 597.17, "end": 597.85, "word": " Ya,", "probability": 0.416259765625}, {"start": 598.51, "end": 599.09, "word": " m,", "probability": 0.62451171875}, {"start": 599.69, "end": 600.15, "word": " n", "probability": 0.98095703125}, {"start": 600.15, "end": 601.11, "word": " and", "probability": 0.62255859375}, {"start": 601.11, "end": 601.91, "word": " ha", "probability": 0.70556640625}, {"start": 601.91, "end": 602.95, "word": " followed", "probability": 0.77099609375}, {"start": 602.95, "end": 603.53, "word": " by", "probability": 0.9716796875}, {"start": 603.53, "end": 604.23, "word": " the", "probability": 0.8828125}, {"start": 604.23, "end": 604.41, "word": " ya", "probability": 0.55517578125}, {"start": 604.41, "end": 604.91, "word": " sound", "probability": 0.921875}, {"start": 604.91, "end": 605.33, "word": " as", "probability": 0.9130859375}, {"start": 605.33, "end": 605.89, "word": " in", "probability": 0.94873046875}, {"start": 605.89, "end": 606.73, "word": " mute,", "probability": 0.93701171875}, {"start": 607.43, "end": 607.93, "word": " muse,", "probability": 0.615234375}, {"start": 608.49, "end": 608.99, "word": " huge.", "probability": 0.88525390625}, {"start": 610.11, "end": 610.83, "word": " So,", "probability": 0.9482421875}], "temperature": 1.0}, {"id": 23, "seek": 63821, "start": 611.89, "end": 638.21, "text": " These are two clusters coming at the beginning of a word as you have seen. We have three clusters, as in spray, spread, spring. So you have your students say spring or spring or spring. So this is Arabic, okay? 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Again, three clusters, scream, screen, scroll, script. Also, we have three clusters in student, stupid. Three clusters as in skew,", "tokens": [492, 362, 1045, 23313, 382, 7038, 294, 7799, 11, 10099, 11, 4244, 11, 10910, 13, 3764, 11, 1045, 23313, 11, 7291, 11, 2568, 11, 11369, 11, 5755, 13, 2743, 11, 321, 362, 1045, 23313, 294, 3107, 11, 6631, 13, 6244, 23313, 382, 294, 8756, 86, 11], "avg_logprob": -0.14212100683374607, "compression_ratio": 1.7033898305084745, "no_speech_prob": 0.0, "words": [{"start": 640.27, "end": 640.51, "word": " We", "probability": 0.89990234375}, {"start": 640.51, "end": 640.71, "word": " have", "probability": 0.95068359375}, {"start": 640.71, "end": 640.93, "word": " three", "probability": 0.892578125}, {"start": 640.93, "end": 641.35, "word": " clusters", "probability": 0.9404296875}, {"start": 641.35, "end": 642.75, "word": " as", "probability": 0.66162109375}, {"start": 642.75, "end": 643.31, "word": " appears", "probability": 0.82568359375}, {"start": 643.31, "end": 643.77, "word": " in", "probability": 0.9443359375}, {"start": 643.77, "end": 644.61, "word": " struggle,", "probability": 0.880859375}, {"start": 645.43, "end": 645.83, "word": " straw,", "probability": 0.33154296875}, {"start": 646.51, "end": 647.05, "word": " stress,", "probability": 0.916015625}, {"start": 647.67, "end": 648.07, "word": " strict.", "probability": 0.94482421875}, {"start": 650.55, "end": 651.47, "word": " Again,", "probability": 0.9375}, {"start": 651.65, "end": 651.87, "word": " three", "probability": 0.931640625}, {"start": 651.87, "end": 652.37, "word": " clusters,", "probability": 0.93603515625}, {"start": 653.41, "end": 653.87, "word": " scream,", "probability": 0.83203125}, {"start": 654.61, "end": 655.23, "word": " screen,", "probability": 0.85791015625}, {"start": 655.89, "end": 656.31, "word": " scroll,", "probability": 0.5322265625}, {"start": 656.87, "end": 657.33, "word": " script.", "probability": 0.95849609375}, {"start": 660.47, "end": 661.39, "word": " Also,", "probability": 0.94482421875}, {"start": 661.45, "end": 661.59, "word": " we", "probability": 0.93505859375}, {"start": 661.59, "end": 661.77, "word": " have", "probability": 0.94677734375}, {"start": 661.77, "end": 661.97, "word": " three", "probability": 0.93310546875}, {"start": 661.97, "end": 662.37, "word": " clusters", "probability": 0.9345703125}, {"start": 662.37, "end": 662.79, "word": " in", "probability": 0.94091796875}, {"start": 662.79, "end": 663.47, "word": " student,", "probability": 0.9482421875}, {"start": 664.33, "end": 664.67, "word": " stupid.", "probability": 0.9609375}, {"start": 666.25, "end": 667.17, "word": " Three", "probability": 0.9521484375}, {"start": 667.17, "end": 667.63, "word": " clusters", "probability": 0.9365234375}, {"start": 667.63, "end": 668.21, "word": " as", "probability": 0.8818359375}, {"start": 668.21, "end": 668.51, "word": " in", "probability": 0.93017578125}, {"start": 668.51, "end": 668.97, "word": " skew,", "probability": 0.896728515625}], "temperature": 1.0}, {"id": 25, "seek": 70105, "start": 671.81, "end": 701.05, "text": " And splash, splendid, split, squad, square, squash, squeezes. We have two or more consonants at the end of a word, not at the beginning. So we have sah, ts, and z. At the end of the noun, as in fields,", "tokens": [400, 25757, 11, 47575, 11, 7472, 11, 15310, 11, 3732, 11, 30725, 11, 22390, 279, 13, 492, 362, 732, 420, 544, 30843, 1719, 412, 264, 917, 295, 257, 1349, 11, 406, 412, 264, 2863, 13, 407, 321, 362, 19292, 11, 35492, 11, 293, 710, 13, 1711, 264, 917, 295, 264, 23307, 11, 382, 294, 7909, 11], "avg_logprob": -0.20504385337494968, "compression_ratio": 1.4852941176470589, "no_speech_prob": 0.0, "words": [{"start": 671.81, "end": 672.25, "word": " And", "probability": 0.499267578125}, {"start": 672.25, "end": 673.03, "word": " splash,", "probability": 0.5341796875}, {"start": 673.37, "end": 673.85, "word": " splendid,", "probability": 0.904296875}, {"start": 674.43, "end": 674.89, "word": " split,", "probability": 0.94775390625}, {"start": 676.33, "end": 677.51, "word": " squad,", "probability": 0.6025390625}, {"start": 678.45, "end": 679.03, "word": " square,", "probability": 0.794921875}, {"start": 679.67, "end": 680.17, "word": " squash,", "probability": 0.97802734375}, {"start": 680.69, "end": 681.53, "word": " squeezes.", "probability": 0.888916015625}, {"start": 686.73, "end": 687.49, "word": " We", "probability": 0.95654296875}, {"start": 687.49, "end": 687.73, "word": " have", "probability": 0.9501953125}, {"start": 687.73, "end": 688.03, "word": " two", "probability": 0.92578125}, {"start": 688.03, "end": 688.41, "word": " or", "probability": 0.95849609375}, {"start": 688.41, "end": 688.67, "word": " more", "probability": 0.935546875}, {"start": 688.67, "end": 689.29, "word": " consonants", "probability": 0.984130859375}, {"start": 689.29, "end": 689.47, "word": " at", "probability": 0.95751953125}, {"start": 689.47, "end": 689.59, "word": " the", "probability": 0.91943359375}, {"start": 689.59, "end": 689.75, "word": " end", "probability": 0.89306640625}, {"start": 689.75, "end": 689.89, "word": " of", "probability": 0.9697265625}, {"start": 689.89, "end": 690.03, "word": " a", "probability": 0.896484375}, {"start": 690.03, "end": 690.27, "word": " word,", "probability": 0.9453125}, {"start": 690.45, "end": 690.59, "word": " not", "probability": 0.92626953125}, {"start": 690.59, "end": 690.91, "word": " at", "probability": 0.95068359375}, {"start": 690.91, "end": 691.03, "word": " the", "probability": 0.9228515625}, {"start": 691.03, "end": 691.41, "word": " beginning.", "probability": 0.91064453125}, {"start": 692.89, "end": 693.65, "word": " So", "probability": 0.6630859375}, {"start": 693.65, "end": 693.87, "word": " we", "probability": 0.7421875}, {"start": 693.87, "end": 694.23, "word": " have", "probability": 0.9453125}, {"start": 694.23, "end": 694.67, "word": " sah,", "probability": 0.342529296875}, {"start": 694.99, "end": 695.51, "word": " ts,", "probability": 0.192626953125}, {"start": 695.75, "end": 696.05, "word": " and", "probability": 0.91748046875}, {"start": 696.05, "end": 696.35, "word": " z.", "probability": 0.93896484375}, {"start": 696.79, "end": 697.23, "word": " At", "probability": 0.94873046875}, {"start": 697.23, "end": 697.37, "word": " the", "probability": 0.91943359375}, {"start": 697.37, "end": 697.53, "word": " end", "probability": 0.8935546875}, {"start": 697.53, "end": 697.67, "word": " of", "probability": 0.97216796875}, {"start": 697.67, "end": 698.35, "word": " the", "probability": 0.751953125}, {"start": 698.35, "end": 698.69, "word": " noun,", "probability": 0.97265625}, {"start": 700.19, "end": 700.47, "word": " as", "probability": 0.96630859375}, {"start": 700.47, "end": 700.63, "word": " in", "probability": 0.94482421875}, {"start": 700.63, "end": 701.05, "word": " fields,", "probability": 0.74072265625}], "temperature": 1.0}, {"id": 26, "seek": 72807, "start": 702.15, "end": 728.07, "text": " Box, dogs, two clusters at the end of a word. We have ts, z. At the end of verbs, not nouns, the third person in present tense, as you know, eats, gives, risks, yields. We also have the allophones.", "tokens": [15112, 11, 7197, 11, 732, 23313, 412, 264, 917, 295, 257, 1349, 13, 492, 362, 35492, 11, 710, 13, 1711, 264, 917, 295, 30051, 11, 406, 48184, 11, 264, 2636, 954, 294, 1974, 18760, 11, 382, 291, 458, 11, 18109, 11, 2709, 11, 10888, 11, 32168, 13, 492, 611, 362, 264, 439, 5317, 2213, 13], "avg_logprob": -0.16908482116247928, "compression_ratio": 1.4042553191489362, "no_speech_prob": 0.0, "words": [{"start": 702.15, "end": 702.71, "word": " Box,", "probability": 0.6796875}, {"start": 703.65, "end": 704.03, "word": " dogs,", "probability": 0.86669921875}, {"start": 704.25, "end": 704.43, "word": " two", "probability": 0.9365234375}, {"start": 704.43, "end": 704.83, "word": " clusters", "probability": 0.9365234375}, {"start": 704.83, "end": 705.55, "word": " at", "probability": 0.78759765625}, {"start": 705.55, "end": 705.69, "word": " the", "probability": 0.9228515625}, {"start": 705.69, "end": 705.85, "word": " end", "probability": 0.90234375}, {"start": 705.85, "end": 706.01, "word": " of", "probability": 0.9716796875}, {"start": 706.01, "end": 706.11, "word": " a", "probability": 0.90478515625}, {"start": 706.11, "end": 706.41, "word": " word.", "probability": 0.9443359375}, {"start": 708.53, "end": 709.37, "word": " We", "probability": 0.9599609375}, {"start": 709.37, "end": 709.95, "word": " have", "probability": 0.95556640625}, {"start": 709.95, "end": 710.69, "word": " ts,", "probability": 0.1416015625}, {"start": 711.23, "end": 711.65, "word": " z.", "probability": 0.9521484375}, {"start": 712.41, "end": 712.89, "word": " At", "probability": 0.9521484375}, {"start": 712.89, "end": 713.01, "word": " the", "probability": 0.91943359375}, {"start": 713.01, "end": 713.17, "word": " end", "probability": 0.892578125}, {"start": 713.17, "end": 713.35, "word": " of", "probability": 0.97265625}, {"start": 713.35, "end": 713.73, "word": " verbs,", "probability": 0.93603515625}, {"start": 713.93, "end": 714.07, "word": " not", "probability": 0.94677734375}, {"start": 714.07, "end": 714.51, "word": " nouns,", "probability": 0.96044921875}, {"start": 715.55, "end": 715.67, "word": " the", "probability": 0.90673828125}, {"start": 715.67, "end": 715.95, "word": " third", "probability": 0.9365234375}, {"start": 715.95, "end": 716.49, "word": " person", "probability": 0.90087890625}, {"start": 716.49, "end": 717.53, "word": " in", "probability": 0.6826171875}, {"start": 717.53, "end": 717.77, "word": " present", "probability": 0.947265625}, {"start": 717.77, "end": 718.21, "word": " tense,", "probability": 0.91650390625}, {"start": 718.35, "end": 718.41, "word": " as", "probability": 0.96826171875}, {"start": 718.41, "end": 718.55, "word": " you", "probability": 0.9677734375}, {"start": 718.55, "end": 718.81, "word": " know,", "probability": 0.89404296875}, {"start": 719.13, "end": 719.57, "word": " eats,", "probability": 0.92236328125}, {"start": 720.25, "end": 720.69, "word": " gives,", "probability": 0.92431640625}, {"start": 721.41, "end": 721.83, "word": " risks,", "probability": 0.8203125}, {"start": 722.71, "end": 723.07, "word": " yields.", "probability": 0.90673828125}, {"start": 724.99, "end": 725.83, "word": " We", "probability": 0.96484375}, {"start": 725.83, "end": 726.19, "word": " also", "probability": 0.8837890625}, {"start": 726.19, "end": 726.63, "word": " have", "probability": 0.947265625}, {"start": 726.63, "end": 727.39, "word": " the", "probability": 0.8857421875}, {"start": 727.39, "end": 728.07, "word": " allophones.", "probability": 0.92578125}], "temperature": 1.0}, {"id": 27, "seek": 75146, "start": 729.02, "end": 751.46, "text": " Ta and Da, two consonants at the end of a verb, okay, in the past, as in wished, raised, risked, plunged. You'll find your students say wished, they fracture the clusterization system. Raised, okay, they pronounce these wrongly.", "tokens": [6551, 293, 3933, 11, 732, 30843, 1719, 412, 264, 917, 295, 257, 9595, 11, 1392, 11, 294, 264, 1791, 11, 382, 294, 25811, 11, 6005, 11, 3148, 292, 11, 37663, 292, 13, 509, 603, 915, 428, 1731, 584, 25811, 11, 436, 36877, 264, 13630, 2144, 1185, 13, 43374, 292, 11, 1392, 11, 436, 19567, 613, 2085, 356, 13], "avg_logprob": -0.24933793686204037, "compression_ratio": 1.4493670886075949, "no_speech_prob": 0.0, "words": [{"start": 729.02, "end": 729.34, "word": " Ta", "probability": 0.296875}, {"start": 729.34, "end": 729.94, "word": " and", "probability": 0.91357421875}, {"start": 729.94, "end": 730.14, "word": " Da,", "probability": 0.52783203125}, {"start": 730.8, "end": 731.0, "word": " two", "probability": 0.9365234375}, {"start": 731.0, "end": 731.7, "word": " consonants", "probability": 0.9833984375}, {"start": 731.7, "end": 732.62, "word": " at", "probability": 0.78076171875}, {"start": 732.62, "end": 732.74, "word": " the", "probability": 0.92626953125}, {"start": 732.74, "end": 732.88, "word": " end", "probability": 0.90576171875}, {"start": 732.88, "end": 733.02, "word": " of", "probability": 0.97412109375}, {"start": 733.02, "end": 733.18, "word": " a", "probability": 0.9677734375}, {"start": 733.18, "end": 733.6, "word": " verb,", "probability": 0.90380859375}, {"start": 734.06, "end": 734.3, "word": " okay,", "probability": 0.81787109375}, {"start": 734.32, "end": 734.44, "word": " in", "probability": 0.9482421875}, {"start": 734.44, "end": 734.56, "word": " the", "probability": 0.921875}, {"start": 734.56, "end": 734.98, "word": " past,", "probability": 0.89794921875}, {"start": 735.58, "end": 735.68, "word": " as", "probability": 0.97119140625}, {"start": 735.68, "end": 735.84, "word": " in", "probability": 0.9345703125}, {"start": 735.84, "end": 736.14, "word": " wished,", "probability": 0.7978515625}, {"start": 737.34, "end": 737.78, "word": " raised,", "probability": 0.94580078125}, {"start": 738.52, "end": 739.1, "word": " risked,", "probability": 0.706298828125}, {"start": 739.56, "end": 740.24, "word": " plunged.", "probability": 0.6876220703125}, {"start": 740.66, "end": 740.88, "word": " You'll", "probability": 0.777099609375}, {"start": 740.88, "end": 741.08, "word": " find", "probability": 0.88671875}, {"start": 741.08, "end": 741.2, "word": " your", "probability": 0.50634765625}, {"start": 741.2, "end": 741.46, "word": " students", "probability": 0.88525390625}, {"start": 741.46, "end": 741.94, "word": " say", "probability": 0.9423828125}, {"start": 741.94, "end": 742.36, "word": " wished,", "probability": 0.44921875}, {"start": 743.44, "end": 743.76, "word": " they", "probability": 0.88671875}, {"start": 743.76, "end": 744.26, "word": " fracture", "probability": 0.8505859375}, {"start": 744.26, "end": 744.96, "word": " the", "probability": 0.85302734375}, {"start": 744.96, "end": 745.7, "word": " clusterization", "probability": 0.835205078125}, {"start": 745.7, "end": 746.28, "word": " system.", "probability": 0.953125}, {"start": 746.86, "end": 747.44, "word": " Raised,", "probability": 0.962890625}, {"start": 748.02, "end": 748.72, "word": " okay,", "probability": 0.90283203125}, {"start": 749.26, "end": 749.6, "word": " they", "probability": 0.88623046875}, {"start": 749.6, "end": 750.02, "word": " pronounce", "probability": 0.919921875}, {"start": 750.02, "end": 750.5, "word": " these", "probability": 0.86474609375}, {"start": 750.5, "end": 751.46, "word": " wrongly.", "probability": 0.91552734375}], "temperature": 1.0}, {"id": 28, "seek": 78198, "start": 752.66, "end": 781.98, "text": " The Fah at the end of a noun and numbers as in width, strength, seventh. Okay? So you have two clusters at the end of a word. Okay? You have the Fah followed by plural nouns as numerals as in breadth, seventh, eighth, et cetera. So we have clusterization system at the end of words. We have three clusters.", "tokens": [440, 479, 545, 412, 264, 917, 295, 257, 23307, 293, 3547, 382, 294, 11402, 11, 3800, 11, 17875, 13, 1033, 30, 407, 291, 362, 732, 23313, 412, 264, 917, 295, 257, 1349, 13, 1033, 30, 509, 362, 264, 479, 545, 6263, 538, 25377, 48184, 382, 7866, 1124, 382, 294, 35862, 11, 17875, 11, 19495, 11, 1030, 11458, 13, 407, 321, 362, 13630, 2144, 1185, 412, 264, 917, 295, 2283, 13, 492, 362, 1045, 23313, 13], "avg_logprob": -0.1714638140248625, "compression_ratio": 1.7443181818181819, "no_speech_prob": 0.0, "words": [{"start": 752.66, "end": 753.08, "word": " The", "probability": 0.4453125}, {"start": 753.08, "end": 753.44, "word": " Fah", "probability": 0.392669677734375}, {"start": 753.44, "end": 753.62, "word": " at", "probability": 0.8671875}, {"start": 753.62, "end": 753.76, "word": " the", "probability": 0.92138671875}, {"start": 753.76, "end": 753.9, "word": " end", "probability": 0.8974609375}, {"start": 753.9, "end": 754.06, "word": " of", 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"probability": 0.9208984375}, {"start": 767.74, "end": 768.02, "word": " Fah", "probability": 0.966064453125}, {"start": 768.02, "end": 768.4, "word": " followed", "probability": 0.85302734375}, {"start": 768.4, "end": 768.78, "word": " by", "probability": 0.9736328125}, {"start": 768.78, "end": 769.18, "word": " plural", "probability": 0.97119140625}, {"start": 769.18, "end": 769.74, "word": " nouns", "probability": 0.9560546875}, {"start": 769.74, "end": 770.66, "word": " as", "probability": 0.87158203125}, {"start": 770.66, "end": 771.24, "word": " numerals", "probability": 0.962646484375}, {"start": 771.24, "end": 771.7, "word": " as", "probability": 0.77685546875}, {"start": 771.7, "end": 772.06, "word": " in", "probability": 0.92724609375}, {"start": 772.06, "end": 772.46, "word": " breadth,", "probability": 0.9501953125}, {"start": 773.3, "end": 773.8, "word": " seventh,", "probability": 0.87353515625}, {"start": 774.46, "end": 774.88, "word": " eighth,", "probability": 0.84375}, {"start": 775.3, "end": 775.42, "word": " et", "probability": 0.405029296875}, {"start": 775.42, "end": 775.66, "word": " cetera.", "probability": 0.89990234375}, {"start": 777.32, "end": 778.12, "word": " So", "probability": 0.94970703125}, {"start": 778.12, "end": 778.24, "word": " we", "probability": 0.77001953125}, {"start": 778.24, "end": 778.36, "word": " have", "probability": 0.943359375}, {"start": 778.36, "end": 779.06, "word": " clusterization", "probability": 0.70751953125}, {"start": 779.06, "end": 779.58, "word": " system", "probability": 0.93359375}, {"start": 779.58, "end": 780.24, "word": " at", "probability": 0.9541015625}, {"start": 780.24, "end": 780.36, "word": " the", "probability": 0.916015625}, {"start": 780.36, "end": 780.5, "word": " end", "probability": 0.8955078125}, {"start": 780.5, "end": 780.68, "word": " of", "probability": 0.97021484375}, {"start": 780.68, "end": 780.94, "word": " words.", "probability": 0.89404296875}, {"start": 781.06, "end": 781.18, "word": " We", "probability": 0.9580078125}, {"start": 781.18, "end": 781.32, "word": " have", "probability": 0.94677734375}, {"start": 781.32, "end": 781.54, "word": " three", "probability": 0.9287109375}, {"start": 781.54, "end": 781.98, "word": " clusters.", "probability": 0.9482421875}], "temperature": 1.0}, {"id": 29, "seek": 80309, "start": 783.99, "end": 803.09, "text": " Long skirt. Long skirt. You find your students say long skirt, okay, which is completely wrong. Now, if you look to this,", "tokens": [8282, 20134, 13, 8282, 20134, 13, 509, 915, 428, 1731, 584, 938, 20134, 11, 1392, 11, 597, 307, 2584, 2085, 13, 823, 11, 498, 291, 574, 281, 341, 11], "avg_logprob": -0.2651041567325592, "compression_ratio": 1.2448979591836735, "no_speech_prob": 0.0, "words": [{"start": 783.99, "end": 784.41, "word": " Long", "probability": 0.384765625}, {"start": 784.41, "end": 784.81, "word": " skirt.", "probability": 0.81884765625}, {"start": 786.29, "end": 786.93, "word": " Long", "probability": 0.76806640625}, {"start": 786.93, "end": 787.35, "word": " skirt.", "probability": 0.9853515625}, {"start": 787.51, "end": 787.63, "word": " You", "probability": 0.9404296875}, {"start": 787.63, "end": 787.91, "word": " find", "probability": 0.5205078125}, {"start": 787.91, "end": 788.09, "word": " your", "probability": 0.63037109375}, {"start": 788.09, "end": 788.27, "word": " students", "probability": 0.60693359375}, {"start": 788.27, "end": 788.61, "word": " say", "probability": 0.8876953125}, {"start": 788.61, "end": 789.05, "word": " long", "probability": 0.52001953125}, {"start": 789.05, "end": 789.49, "word": " skirt,", "probability": 0.982421875}, {"start": 790.39, "end": 790.69, "word": " okay,", "probability": 0.7685546875}, {"start": 791.01, "end": 791.31, "word": " which", "probability": 0.94189453125}, {"start": 791.31, "end": 791.51, "word": " is", "probability": 0.9521484375}, {"start": 791.51, "end": 791.99, "word": " completely", "probability": 0.76513671875}, {"start": 791.99, "end": 792.87, "word": " wrong.", "probability": 0.9287109375}, {"start": 801.51, "end": 802.15, "word": " Now,", "probability": 0.95703125}, {"start": 802.19, "end": 802.37, "word": " if", "probability": 0.95166015625}, {"start": 802.37, "end": 802.49, "word": " you", "probability": 0.9638671875}, {"start": 802.49, "end": 802.65, "word": " look", "probability": 0.96923828125}, {"start": 802.65, "end": 802.81, "word": " to", "probability": 0.9443359375}, {"start": 802.81, "end": 803.09, "word": " this,", "probability": 0.9521484375}], "temperature": 1.0}, {"id": 30, "seek": 82423, "start": 804.73, "end": 824.23, "text": " chart, you find the clusterization system in English and Arabic. English accepts two clusters, the beginning of a word, the middle part of a word, the final part. Also, we have three clusters, the middle,", "tokens": [6927, 11, 291, 915, 264, 13630, 2144, 1185, 294, 3669, 293, 19938, 13, 3669, 33538, 732, 23313, 11, 264, 2863, 295, 257, 1349, 11, 264, 2808, 644, 295, 257, 1349, 11, 264, 2572, 644, 13, 2743, 11, 321, 362, 1045, 23313, 11, 264, 2808, 11], "avg_logprob": -0.19633151914762415, "compression_ratio": 1.5648854961832062, "no_speech_prob": 8.940696716308594e-07, "words": [{"start": 804.73, "end": 805.35, "word": " chart,", "probability": 0.2958984375}, {"start": 805.59, "end": 805.67, "word": " you", "probability": 0.94970703125}, {"start": 805.67, "end": 806.11, "word": " find", "probability": 0.7373046875}, {"start": 806.11, "end": 807.23, "word": " the", "probability": 0.798828125}, {"start": 807.23, "end": 808.41, "word": " clusterization", "probability": 0.699951171875}, {"start": 808.41, "end": 808.93, "word": " system", "probability": 0.9384765625}, {"start": 808.93, "end": 809.67, "word": " in", "probability": 0.9306640625}, {"start": 809.67, "end": 810.03, "word": " English", "probability": 0.97705078125}, {"start": 810.03, "end": 810.57, "word": " and", "probability": 0.94482421875}, {"start": 810.57, "end": 811.05, "word": " Arabic.", "probability": 0.87890625}, {"start": 812.01, "end": 812.67, "word": " English", "probability": 0.98046875}, {"start": 812.67, "end": 813.37, "word": " accepts", "probability": 0.814453125}, {"start": 813.37, "end": 813.73, "word": " two", "probability": 0.90185546875}, {"start": 813.73, "end": 814.23, "word": " clusters,", "probability": 0.919921875}, {"start": 815.01, "end": 815.17, "word": " the", "probability": 0.826171875}, {"start": 815.17, "end": 815.55, "word": " beginning", "probability": 0.9248046875}, {"start": 815.55, "end": 815.79, "word": " of", "probability": 0.96728515625}, {"start": 815.79, "end": 815.95, "word": " a", "probability": 0.8642578125}, {"start": 815.95, "end": 816.23, "word": " word,", "probability": 0.9462890625}, {"start": 817.19, "end": 817.25, "word": " the", "probability": 0.87548828125}, {"start": 817.25, "end": 817.97, "word": " middle", "probability": 0.509765625}, {"start": 817.97, "end": 818.89, "word": " part", "probability": 0.87939453125}, {"start": 818.89, "end": 819.09, "word": " of", "probability": 0.96484375}, {"start": 819.09, "end": 819.23, "word": " a", "probability": 0.90625}, {"start": 819.23, "end": 819.53, "word": " word,", "probability": 0.93212890625}, {"start": 820.21, "end": 820.33, "word": " the", "probability": 0.55078125}, {"start": 820.33, "end": 820.67, "word": " final", "probability": 0.9375}, {"start": 820.67, "end": 821.13, "word": " part.", "probability": 0.89306640625}, {"start": 821.71, "end": 822.15, "word": " Also,", "probability": 0.91162109375}, {"start": 822.19, "end": 822.29, "word": " we", "probability": 0.84228515625}, {"start": 822.29, "end": 822.41, "word": " have", "probability": 0.94775390625}, {"start": 822.41, "end": 822.61, "word": " three", "probability": 0.9306640625}, {"start": 822.61, "end": 823.07, "word": " clusters,", "probability": 0.92431640625}, {"start": 823.77, "end": 823.93, "word": " the", "probability": 0.90087890625}, {"start": 823.93, "end": 824.23, "word": " middle,", "probability": 0.947265625}], "temperature": 1.0}, {"id": 31, "seek": 85293, "start": 825.37, "end": 852.93, "text": " media in the initial part, medial part, final part. We have four clusters at the middle and also at the end of a word. Arabic accepts only two clusters at the end of a word as in nahr, nahr, bent, etc. Okay? Also in the middle of the word. You have this cluster appears in Arabic.", "tokens": [3021, 294, 264, 5883, 644, 11, 1205, 831, 644, 11, 2572, 644, 13, 492, 362, 1451, 23313, 412, 264, 2808, 293, 611, 412, 264, 917, 295, 257, 1349, 13, 19938, 33538, 787, 732, 23313, 412, 264, 917, 295, 257, 1349, 382, 294, 297, 5398, 11, 297, 5398, 11, 14075, 11, 5183, 13, 1033, 30, 2743, 294, 264, 2808, 295, 264, 1349, 13, 509, 362, 341, 13630, 7038, 294, 19938, 13], "avg_logprob": -0.20378521840337296, "compression_ratio": 1.7134146341463414, "no_speech_prob": 0.0, "words": [{"start": 825.37, "end": 825.87, "word": " media", "probability": 0.1904296875}, {"start": 825.87, "end": 826.09, "word": " in", "probability": 0.84814453125}, {"start": 826.09, "end": 826.51, "word": " the", "probability": 0.92041015625}, {"start": 826.51, "end": 827.91, "word": " initial", "probability": 0.88916015625}, {"start": 827.91, "end": 828.51, "word": " part,", "probability": 0.8974609375}, {"start": 829.15, "end": 829.51, "word": " medial", "probability": 0.7183837890625}, {"start": 829.51, "end": 829.97, "word": " part,", "probability": 0.9072265625}, {"start": 830.43, "end": 830.79, "word": " final", "probability": 0.88818359375}, {"start": 830.79, "end": 831.23, "word": " part.", "probability": 0.89892578125}, {"start": 831.33, "end": 831.49, "word": " We", "probability": 0.95849609375}, {"start": 831.49, "end": 831.65, "word": " have", "probability": 0.9541015625}, {"start": 831.65, "end": 831.91, "word": " four", "probability": 0.9140625}, {"start": 831.91, "end": 832.35, "word": " clusters", "probability": 0.92724609375}, {"start": 832.35, "end": 833.53, "word": " at", "probability": 0.71630859375}, {"start": 833.53, "end": 833.65, "word": " the", "probability": 0.9228515625}, {"start": 833.65, "end": 834.43, "word": " middle", "probability": 0.9189453125}, {"start": 834.43, "end": 835.29, "word": " and", "probability": 0.77392578125}, {"start": 835.29, "end": 835.75, "word": " also", "probability": 0.8642578125}, {"start": 835.75, "end": 836.07, "word": " at", "probability": 0.94189453125}, {"start": 836.07, "end": 836.21, "word": " the", "probability": 0.92041015625}, {"start": 836.21, "end": 836.43, "word": " end", "probability": 0.90625}, {"start": 836.43, "end": 836.59, "word": " of", "probability": 0.97119140625}, {"start": 836.59, "end": 836.75, "word": " a", "probability": 0.8642578125}, {"start": 836.75, "end": 837.03, "word": " word.", "probability": 0.96484375}, {"start": 837.93, "end": 838.19, "word": " Arabic", "probability": 0.92822265625}, {"start": 838.19, "end": 838.87, "word": " accepts", "probability": 0.833984375}, {"start": 838.87, "end": 839.21, "word": " only", "probability": 0.9296875}, {"start": 839.21, "end": 839.49, "word": " two", "probability": 0.93994140625}, {"start": 839.49, "end": 839.93, "word": " clusters", "probability": 0.93701171875}, {"start": 839.93, "end": 840.25, "word": " at", "probability": 0.5537109375}, {"start": 840.25, "end": 840.39, "word": " the", "probability": 0.92333984375}, {"start": 840.39, "end": 840.59, "word": " end", "probability": 0.892578125}, {"start": 840.59, "end": 840.75, "word": " of", "probability": 0.9697265625}, {"start": 840.75, "end": 840.91, "word": " a", "probability": 0.95703125}, {"start": 840.91, "end": 841.15, "word": " word", "probability": 0.93603515625}, {"start": 841.15, "end": 841.45, "word": " as", "probability": 0.578125}, {"start": 841.45, "end": 841.61, "word": " in", "probability": 0.9013671875}, {"start": 841.61, "end": 841.89, "word": " nahr,", "probability": 0.4781494140625}, {"start": 842.33, "end": 842.67, "word": " nahr,", "probability": 0.7978515625}, {"start": 843.49, "end": 843.89, "word": " bent,", "probability": 0.86474609375}, {"start": 844.47, "end": 844.81, "word": " etc.", "probability": 0.409423828125}, {"start": 845.99, "end": 846.33, "word": " Okay?", "probability": 0.491455078125}, {"start": 846.61, "end": 846.99, "word": " Also", "probability": 0.93701171875}, {"start": 846.99, "end": 847.19, "word": " in", "probability": 0.794921875}, {"start": 847.19, "end": 847.33, "word": " the", "probability": 0.91796875}, {"start": 847.33, "end": 847.51, "word": " middle", "probability": 0.95849609375}, {"start": 847.51, "end": 847.95, "word": " of", "probability": 0.9638671875}, {"start": 847.95, "end": 848.07, "word": " the", "probability": 0.92431640625}, {"start": 848.07, "end": 848.35, "word": " word.", "probability": 0.9365234375}, {"start": 849.53, "end": 849.71, "word": " You", "probability": 0.892578125}, {"start": 849.71, "end": 850.15, "word": " have", "probability": 0.94482421875}, {"start": 850.15, "end": 850.81, "word": " this", "probability": 0.88037109375}, {"start": 850.81, "end": 851.55, "word": " cluster", "probability": 0.8408203125}, {"start": 851.55, "end": 852.31, "word": " appears", "probability": 0.8505859375}, {"start": 852.31, "end": 852.61, "word": " in", "probability": 0.95068359375}, {"start": 852.61, "end": 852.93, "word": " Arabic.", "probability": 0.923828125}], "temperature": 1.0}, {"id": 32, "seek": 88955, "start": 860.286, "end": 889.55, "text": " Yes. In connected speech, we have sequence of clusters that may reach seven clusters. So we have banks closed. We have a number of clusters in these two words.", "tokens": [1079, 13, 682, 4582, 6218, 11, 321, 362, 8310, 295, 23313, 300, 815, 2524, 3407, 23313, 13, 407, 321, 362, 10237, 5395, 13, 492, 362, 257, 1230, 295, 23313, 294, 613, 732, 2283, 13], "avg_logprob": -0.09916294600282397, "compression_ratio": 1.4035087719298245, "no_speech_prob": 0.0, "words": [{"start": 860.19, "end": 860.73, "word": " Yes.", "probability": 0.84423828125}, {"start": 864.21, "end": 865.29, "word": " In", "probability": 0.93212890625}, {"start": 865.29, "end": 865.63, "word": " connected", "probability": 0.89111328125}, {"start": 865.63, "end": 866.25, "word": " speech,", "probability": 0.96044921875}, {"start": 866.75, "end": 868.07, "word": " we", "probability": 0.96435546875}, {"start": 868.07, "end": 868.23, "word": " have", "probability": 0.94384765625}, {"start": 868.23, "end": 868.85, "word": " sequence", "probability": 0.8974609375}, {"start": 868.85, "end": 869.19, "word": " of", "probability": 0.96875}, {"start": 869.19, "end": 869.65, "word": " clusters", "probability": 0.93896484375}, {"start": 869.65, "end": 870.65, "word": " that", "probability": 0.92724609375}, {"start": 870.65, "end": 871.17, "word": " may", "probability": 0.74365234375}, {"start": 871.17, "end": 871.63, "word": " reach", "probability": 0.94287109375}, {"start": 871.63, "end": 872.35, "word": " seven", "probability": 0.8525390625}, {"start": 872.35, "end": 874.37, "word": " clusters.", "probability": 0.9423828125}, {"start": 876.15, "end": 877.23, "word": " So", "probability": 0.9130859375}, {"start": 877.23, "end": 877.45, "word": " we", "probability": 0.7861328125}, {"start": 877.45, "end": 877.99, "word": " have", "probability": 0.951171875}, {"start": 877.99, "end": 880.79, "word": " banks", "probability": 0.88232421875}, {"start": 880.79, "end": 881.37, "word": " closed.", "probability": 0.9306640625}, {"start": 884.33, "end": 885.41, "word": " We", "probability": 0.962890625}, {"start": 885.41, "end": 885.61, "word": " have", "probability": 0.94677734375}, {"start": 885.61, "end": 885.73, "word": " a", "probability": 0.998046875}, {"start": 885.73, "end": 886.01, "word": " number", "probability": 0.93017578125}, {"start": 886.01, "end": 886.47, "word": " of", "probability": 0.96875}, {"start": 886.47, "end": 887.01, "word": " clusters", "probability": 0.94384765625}, {"start": 887.01, "end": 888.11, "word": " in", "probability": 0.8955078125}, {"start": 888.11, "end": 888.91, "word": " these", "probability": 0.83349609375}, {"start": 888.91, "end": 889.15, "word": " two", "probability": 0.9404296875}, {"start": 889.15, "end": 889.55, "word": " words.", "probability": 0.62353515625}], "temperature": 1.0}, {"id": 33, "seek": 91796, "start": 890.42, "end": 917.96, "text": " Okay? Now, due to having every single consonant followed by a vowel in Arabic, this causes Arab learners, even in advanced stages, to pronounce English words or English sentences wrongly. This is by fracturing the clusterization system of English and inserting vowels of Arabic.", "tokens": [1033, 30, 823, 11, 3462, 281, 1419, 633, 2167, 43647, 6263, 538, 257, 29410, 294, 19938, 11, 341, 7700, 8625, 23655, 11, 754, 294, 7339, 10232, 11, 281, 19567, 3669, 2283, 420, 3669, 16579, 2085, 356, 13, 639, 307, 538, 17948, 1345, 264, 13630, 2144, 1185, 295, 3669, 293, 46567, 44972, 295, 19938, 13], "avg_logprob": -0.13068181709809737, "compression_ratio": 1.4840425531914894, "no_speech_prob": 0.0, "words": [{"start": 890.42, "end": 890.76, "word": " Okay?", "probability": 0.50146484375}, {"start": 892.14, "end": 892.74, "word": " Now,", "probability": 0.94677734375}, {"start": 892.82, "end": 892.98, "word": " due", "probability": 0.9443359375}, {"start": 892.98, "end": 893.18, "word": " to", "probability": 0.97119140625}, {"start": 893.18, "end": 893.64, "word": " having", "probability": 0.9189453125}, {"start": 893.64, "end": 894.02, "word": " every", "probability": 0.81298828125}, {"start": 894.02, "end": 894.46, "word": " single", "probability": 0.93896484375}, {"start": 894.46, "end": 895.18, "word": " consonant", "probability": 0.65869140625}, {"start": 895.18, "end": 895.66, "word": " followed", "probability": 0.90478515625}, {"start": 895.66, "end": 895.9, "word": " by", "probability": 0.97412109375}, {"start": 895.9, "end": 896.08, "word": " a", "probability": 0.9931640625}, {"start": 896.08, "end": 896.34, "word": " vowel", "probability": 0.9755859375}, {"start": 896.34, "end": 897.52, "word": " in", "probability": 0.8447265625}, {"start": 897.52, "end": 897.84, "word": " Arabic,", "probability": 0.90380859375}, {"start": 898.52, "end": 898.96, "word": " this", "probability": 0.94287109375}, {"start": 898.96, "end": 899.72, "word": " causes", "probability": 0.87744140625}, {"start": 899.72, "end": 900.14, "word": " Arab", "probability": 0.6025390625}, {"start": 900.14, "end": 900.68, "word": " learners,", "probability": 0.9501953125}, {"start": 902.0, "end": 902.32, "word": " even", "probability": 0.87890625}, {"start": 902.32, "end": 902.86, "word": " in", "probability": 0.89892578125}, {"start": 902.86, "end": 903.6, "word": " advanced", "probability": 0.89599609375}, {"start": 903.6, "end": 904.3, "word": " stages,", "probability": 0.9267578125}, {"start": 904.76, "end": 905.36, "word": " to", "probability": 0.97265625}, {"start": 905.36, "end": 906.02, "word": " pronounce", "probability": 0.91650390625}, {"start": 906.02, "end": 906.88, "word": " English", "probability": 0.9765625}, {"start": 906.88, "end": 907.5, "word": " words", "probability": 0.88330078125}, {"start": 907.5, "end": 908.26, "word": " or", "probability": 0.92529296875}, {"start": 908.26, "end": 908.66, "word": " English", "probability": 0.95654296875}, {"start": 908.66, "end": 909.4, "word": " sentences", "probability": 0.95458984375}, {"start": 909.4, "end": 910.38, "word": " wrongly.", "probability": 0.916015625}, {"start": 910.48, "end": 910.68, "word": " This", "probability": 0.90283203125}, {"start": 910.68, "end": 910.82, "word": " is", "probability": 0.9453125}, {"start": 910.82, "end": 911.02, "word": " by", "probability": 0.9775390625}, {"start": 911.02, "end": 911.72, "word": " fracturing", "probability": 0.951904296875}, {"start": 911.72, "end": 912.62, "word": " the", "probability": 0.77978515625}, {"start": 912.62, "end": 913.34, "word": " clusterization", "probability": 0.775634765625}, {"start": 913.34, "end": 913.8, "word": " system", "probability": 0.94775390625}, {"start": 913.8, "end": 914.0, "word": " of", "probability": 0.9697265625}, {"start": 914.0, "end": 914.36, "word": " English", "probability": 0.9765625}, {"start": 914.36, "end": 915.24, "word": " and", "probability": 0.84716796875}, {"start": 915.24, "end": 916.02, "word": " inserting", "probability": 0.86328125}, {"start": 916.02, "end": 917.18, "word": " vowels", "probability": 0.9921875}, {"start": 917.18, "end": 917.6, "word": " of", "probability": 0.97021484375}, {"start": 917.6, "end": 917.96, "word": " Arabic.", "probability": 0.93798828125}], "temperature": 1.0}, {"id": 34, "seek": 94838, "start": 919.38, "end": 948.38, "text": " Okay? So you, as future teachers or translators or users of English, you have to be very aware of the clusterization system in order to pronounce English very, very clearly and fluently. You see? If you look to, for example, grandfather. Grandfather.", "tokens": [1033, 30, 407, 291, 11, 382, 2027, 6023, 420, 5105, 3391, 420, 5022, 295, 3669, 11, 291, 362, 281, 312, 588, 3650, 295, 264, 13630, 2144, 1185, 294, 1668, 281, 19567, 3669, 588, 11, 588, 4448, 293, 5029, 2276, 13, 509, 536, 30, 759, 291, 574, 281, 11, 337, 1365, 11, 14754, 13, 6757, 11541, 13], "avg_logprob": -0.14254385755773177, "compression_ratio": 1.4425287356321839, "no_speech_prob": 0.0, "words": [{"start": 919.38, "end": 919.74, "word": " Okay?", "probability": 0.537109375}, {"start": 920.08, "end": 920.3, "word": " So", "probability": 0.9501953125}, {"start": 920.3, "end": 920.68, "word": " you,", "probability": 0.62158203125}, {"start": 921.0, "end": 921.66, "word": " as", "probability": 0.9716796875}, {"start": 921.66, "end": 922.06, "word": " future", "probability": 0.97314453125}, {"start": 922.06, "end": 922.68, "word": " teachers", "probability": 0.83154296875}, {"start": 922.68, "end": 924.08, "word": " or", "probability": 0.5703125}, {"start": 924.08, "end": 924.86, "word": " translators", "probability": 0.98095703125}, {"start": 924.86, "end": 926.14, "word": " or", "probability": 0.78515625}, {"start": 926.14, "end": 926.48, "word": " users", "probability": 0.94677734375}, {"start": 926.48, "end": 926.76, "word": " of", "probability": 0.9716796875}, {"start": 926.76, "end": 927.18, "word": " English,", "probability": 0.98095703125}, {"start": 927.64, "end": 927.96, "word": " you", "probability": 0.95947265625}, {"start": 927.96, "end": 928.2, "word": " have", "probability": 0.9130859375}, {"start": 928.2, "end": 928.34, "word": " to", "probability": 0.97412109375}, {"start": 928.34, "end": 928.58, "word": " be", "probability": 0.95703125}, {"start": 928.58, "end": 928.94, "word": " very", "probability": 0.86669921875}, {"start": 928.94, "end": 929.4, "word": " aware", "probability": 0.90625}, {"start": 929.4, "end": 930.06, "word": " of", "probability": 0.9697265625}, {"start": 930.06, "end": 930.2, "word": " the", "probability": 0.908203125}, {"start": 930.2, "end": 930.88, "word": " clusterization", "probability": 0.6593017578125}, {"start": 930.88, "end": 931.46, "word": " system", "probability": 0.953125}, {"start": 931.46, "end": 932.18, "word": " in", "probability": 0.90185546875}, {"start": 932.18, "end": 932.3, "word": " order", "probability": 0.91259765625}, {"start": 932.3, "end": 932.5, "word": " to", "probability": 0.97412109375}, {"start": 932.5, "end": 932.84, "word": " pronounce", "probability": 0.92578125}, {"start": 932.84, "end": 933.34, "word": " English", "probability": 0.97900390625}, {"start": 933.34, "end": 933.82, "word": " very,", "probability": 0.8564453125}, {"start": 933.94, "end": 934.06, "word": " very", "probability": 0.8525390625}, {"start": 934.06, "end": 934.5, "word": " clearly", "probability": 0.9111328125}, {"start": 934.5, "end": 935.38, "word": " and", "probability": 0.92724609375}, {"start": 935.38, "end": 935.82, "word": " fluently.", "probability": 0.9765625}, {"start": 941.0, "end": 941.78, "word": " You", "probability": 0.95166015625}, {"start": 941.78, "end": 942.0, "word": " see?", "probability": 0.9306640625}, {"start": 943.82, "end": 944.6, "word": " If", "probability": 0.9736328125}, {"start": 944.6, "end": 944.72, "word": " you", "probability": 0.96240234375}, {"start": 944.72, "end": 944.88, "word": " look", "probability": 0.955078125}, {"start": 944.88, "end": 945.1, "word": " to,", "probability": 0.9580078125}, {"start": 945.24, "end": 945.34, "word": " for", "probability": 0.95263671875}, {"start": 945.34, "end": 945.78, "word": " example,", "probability": 0.97412109375}, {"start": 946.5, "end": 947.3, "word": " grandfather.", "probability": 0.78515625}, {"start": 947.66, "end": 948.38, "word": " Grandfather.", "probability": 0.944091796875}], "temperature": 1.0}, {"id": 35, "seek": 96787, "start": 950.13, "end": 967.87, "text": " You find your students say, grandfather or a grandfather. Okay. So this is due to the interference, the negative interference of their mother tongue. Okay.", "tokens": [509, 915, 428, 1731, 584, 11, 677, 474, 11541, 420, 257, 14754, 13, 1033, 13, 407, 341, 307, 3462, 281, 264, 24497, 11, 264, 3671, 24497, 295, 641, 2895, 10601, 13, 1033, 13], "avg_logprob": -0.2630974141990437, "compression_ratio": 1.4181818181818182, "no_speech_prob": 0.0, "words": [{"start": 950.13, "end": 950.35, "word": " You", "probability": 0.64111328125}, {"start": 950.35, "end": 950.69, "word": " find", "probability": 0.76220703125}, {"start": 950.69, "end": 950.87, "word": " your", "probability": 0.8642578125}, {"start": 950.87, "end": 951.13, "word": " students", "probability": 0.62109375}, {"start": 951.13, "end": 951.47, "word": " say,", "probability": 0.8984375}, {"start": 951.61, "end": 952.37, "word": " grandfather", "probability": 0.53509521484375}, {"start": 952.37, "end": 953.97, "word": " or", "probability": 0.63916015625}, {"start": 953.97, "end": 954.21, "word": " a", "probability": 0.9208984375}, {"start": 954.21, "end": 954.73, "word": " grandfather.", "probability": 0.86181640625}, {"start": 955.81, "end": 955.99, "word": " Okay.", "probability": 0.5556640625}, {"start": 956.79, "end": 957.47, "word": " So", "probability": 0.953125}, {"start": 957.47, "end": 957.71, "word": " this", "probability": 0.75146484375}, {"start": 957.71, "end": 957.91, "word": " is", "probability": 0.9501953125}, {"start": 957.91, "end": 958.19, "word": " due", "probability": 0.95654296875}, {"start": 958.19, "end": 958.75, "word": " to", "probability": 0.970703125}, {"start": 958.75, "end": 959.31, "word": " the", "probability": 0.90087890625}, {"start": 959.31, "end": 959.89, "word": " interference,", "probability": 0.931640625}, {"start": 960.37, "end": 960.47, "word": " the", "probability": 0.9208984375}, {"start": 960.47, "end": 960.83, "word": " negative", "probability": 0.943359375}, {"start": 960.83, "end": 961.55, "word": " interference", "probability": 0.91943359375}, {"start": 961.55, "end": 962.05, "word": " of", "probability": 0.9375}, {"start": 962.05, "end": 962.25, "word": " their", "probability": 0.81982421875}, {"start": 962.25, "end": 962.51, "word": " mother", "probability": 0.869140625}, {"start": 962.51, "end": 962.85, "word": " tongue.", "probability": 0.92626953125}, {"start": 967.19, "end": 967.87, "word": " Okay.", "probability": 0.87646484375}], "temperature": 1.0}, {"id": 36, "seek": 99865, "start": 972.17, "end": 998.65, "text": " The simple past tense is also problematic, mainly once the verb ends in voiceless sound, wished, dropped, passed. So you have your student say wished, dropped, passed, which is completely wrong.", "tokens": [440, 2199, 1791, 18760, 307, 611, 19011, 11, 8704, 1564, 264, 9595, 5314, 294, 1650, 41817, 1626, 11, 25811, 11, 8119, 11, 4678, 13, 407, 291, 362, 428, 3107, 584, 25811, 11, 8119, 11, 4678, 11, 597, 307, 2584, 2085, 13], "avg_logprob": -0.20107887365988322, "compression_ratio": 1.4772727272727273, "no_speech_prob": 0.0, "words": [{"start": 972.17, "end": 972.41, "word": " The", "probability": 0.85400390625}, {"start": 972.41, "end": 972.79, "word": " simple", "probability": 0.91650390625}, {"start": 972.79, "end": 973.13, "word": " past", "probability": 0.880859375}, {"start": 973.13, "end": 973.55, "word": " tense", "probability": 0.94384765625}, {"start": 973.55, "end": 974.69, "word": " is", "probability": 0.92626953125}, {"start": 974.69, "end": 975.15, "word": " also", "probability": 0.861328125}, {"start": 975.15, "end": 976.51, "word": " problematic,", "probability": 0.5888671875}, {"start": 977.19, "end": 977.69, "word": " mainly", "probability": 0.95849609375}, {"start": 977.69, "end": 978.95, "word": " once", "probability": 0.77490234375}, {"start": 978.95, "end": 979.25, "word": " the", "probability": 0.92822265625}, {"start": 979.25, "end": 979.77, "word": " verb", "probability": 0.91796875}, {"start": 979.77, "end": 980.39, "word": " ends", "probability": 0.875}, {"start": 980.39, "end": 980.73, "word": " in", "probability": 0.9482421875}, {"start": 980.73, "end": 981.17, "word": " voiceless", "probability": 0.968505859375}, {"start": 981.17, "end": 981.79, "word": " sound,", "probability": 0.81640625}, {"start": 982.89, "end": 983.15, "word": " wished,", "probability": 0.78955078125}, {"start": 986.41, "end": 986.87, "word": " dropped,", "probability": 0.3359375}, {"start": 988.45, "end": 988.93, "word": " passed.", "probability": 0.81787109375}, {"start": 989.23, "end": 989.67, "word": " So", "probability": 0.96044921875}, {"start": 989.67, "end": 989.79, "word": " you", "probability": 0.7978515625}, {"start": 989.79, "end": 990.01, "word": " have", "probability": 0.94873046875}, {"start": 990.01, "end": 990.17, "word": " your", "probability": 0.8857421875}, {"start": 990.17, "end": 990.69, "word": " student", "probability": 0.9091796875}, {"start": 990.69, "end": 992.55, "word": " say", "probability": 0.93359375}, {"start": 992.55, "end": 993.51, "word": " wished,", "probability": 0.485595703125}, {"start": 994.87, "end": 995.13, "word": " dropped,", "probability": 0.70166015625}, {"start": 995.87, "end": 996.63, "word": " passed,", "probability": 0.7626953125}, {"start": 997.01, "end": 997.53, "word": " which", "probability": 0.9521484375}, {"start": 997.53, "end": 997.77, "word": " is", "probability": 0.947265625}, {"start": 997.77, "end": 998.19, "word": " completely", "probability": 0.7509765625}, {"start": 998.19, "end": 998.65, "word": " wrong.", "probability": 0.9248046875}], "temperature": 1.0}, {"id": 37, "seek": 102457, "start": 999.81, "end": 1024.57, "text": " So you have to be aware of that. Another serious problem is related to doubling, or what is called gemination of Arabic. We don't have sheddah in English. So why do you transfer the gemination system of Arabic into English? Now if we need to pronounce these words, who could just pronounce them for me? 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Yes, continue. Command, command, illegal, command. So now you insert the gemination system. You are the best example of just committing mistakes here. Another one. Love, time, love, time, friend.", "tokens": [2690, 11, 40378, 11, 40378, 13, 1079, 11, 2354, 13, 17901, 11, 5622, 11, 11905, 11, 5622, 13, 407, 586, 291, 8969, 264, 7173, 2486, 1185, 13, 509, 366, 264, 1151, 1365, 295, 445, 26659, 8038, 510, 13, 3996, 472, 13, 5956, 11, 565, 11, 959, 11, 565, 11, 1277, 13], "avg_logprob": -0.32151442766189575, "compression_ratio": 1.4666666666666666, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 1029.5, "end": 1030.44, "word": " attack,", "probability": 0.3125}, {"start": 1031.4, "end": 1032.26, "word": " posing,", "probability": 0.7236328125}, {"start": 1033.58, "end": 1034.38, "word": " posing.", "probability": 0.9140625}, {"start": 1036.02, "end": 1036.96, "word": " Yes,", "probability": 0.40478515625}, {"start": 1037.58, "end": 1038.0, "word": " continue.", "probability": 0.92138671875}, {"start": 1038.12, "end": 1038.54, "word": " Command,", "probability": 0.415771484375}, {"start": 1038.88, "end": 1039.28, "word": " command,", "probability": 0.8291015625}, {"start": 1039.74, "end": 1040.24, "word": " illegal,", "probability": 0.8935546875}, {"start": 1040.58, "end": 1040.84, "word": " command.", "probability": 0.65185546875}, {"start": 1041.28, "end": 1041.68, "word": " So", "probability": 0.82470703125}, {"start": 1041.68, "end": 1041.96, "word": " now", "probability": 0.802734375}, {"start": 1041.96, "end": 1042.14, "word": " you", "probability": 0.79443359375}, {"start": 1042.14, "end": 1042.62, "word": " insert", "probability": 0.681640625}, {"start": 1042.62, "end": 1042.82, "word": " the", "probability": 0.9228515625}, {"start": 1042.82, "end": 1043.2, "word": " gemination", "probability": 0.5518798828125}, {"start": 1043.2, "end": 1043.66, "word": " system.", "probability": 0.95703125}, {"start": 1043.76, "end": 1043.86, "word": " You", "probability": 0.96337890625}, {"start": 1043.86, "end": 1044.06, "word": " are", "probability": 0.94189453125}, {"start": 1044.06, "end": 1044.2, "word": " the", "probability": 0.92138671875}, {"start": 1044.2, "end": 1044.44, "word": " best", "probability": 0.9228515625}, {"start": 1044.44, "end": 1044.92, "word": " example", "probability": 0.9736328125}, {"start": 1044.92, "end": 1045.94, "word": " of", "probability": 0.9658203125}, {"start": 1045.94, "end": 1046.64, "word": " just", "probability": 0.9052734375}, {"start": 1046.64, "end": 1047.04, "word": " committing", "probability": 0.92138671875}, {"start": 1047.04, "end": 1047.54, "word": " mistakes", "probability": 0.8984375}, {"start": 1047.54, "end": 1047.9, "word": " here.", "probability": 0.84521484375}, {"start": 1048.4, "end": 1049.16, "word": " Another", "probability": 0.8876953125}, {"start": 1049.16, "end": 1049.54, "word": " one.", "probability": 0.9296875}, {"start": 1052.3, "end": 1053.24, "word": " Love,", "probability": 0.48974609375}, {"start": 1053.8, "end": 1054.34, "word": " time,", "probability": 0.1954345703125}, {"start": 1055.06, "end": 1055.48, "word": " love,", "probability": 0.9306640625}, {"start": 1056.4, "end": 1057.22, "word": " time,", "probability": 0.273681640625}, {"start": 1058.02, "end": 1058.42, "word": " friend.", "probability": 0.320068359375}], "temperature": 1.0}, {"id": 39, "seek": 108390, "start": 1061.28, "end": 1083.9, "text": " You use contraction. You omitted some vowels, some parts of the words. Okay. We don't have the Hamza in English, the glottal sound.", "tokens": [509, 764, 37372, 13, 509, 3406, 3944, 512, 44972, 11, 512, 3166, 295, 264, 2283, 13, 1033, 13, 492, 500, 380, 362, 264, 8234, 2394, 294, 3669, 11, 264, 1563, 1521, 304, 1626, 13], "avg_logprob": -0.1963169651372092, "compression_ratio": 1.1785714285714286, "no_speech_prob": 0.0, "words": [{"start": 1061.28, "end": 1061.5, "word": " You", "probability": 0.69775390625}, {"start": 1061.5, "end": 1061.78, "word": " use", "probability": 0.4375}, {"start": 1061.78, "end": 1062.32, "word": " contraction.", "probability": 0.7451171875}, {"start": 1063.1, "end": 1063.28, "word": " You", "probability": 0.95849609375}, {"start": 1063.28, "end": 1063.88, "word": " omitted", "probability": 0.949951171875}, {"start": 1063.88, "end": 1064.7, "word": " some", "probability": 0.90625}, {"start": 1064.7, "end": 1065.26, "word": " vowels,", "probability": 0.98291015625}, {"start": 1065.92, "end": 1066.14, "word": " some", "probability": 0.88623046875}, {"start": 1066.14, "end": 1066.5, "word": " parts", "probability": 0.8359375}, {"start": 1066.5, "end": 1066.74, "word": " of", "probability": 0.970703125}, {"start": 1066.74, "end": 1067.76, "word": " the", "probability": 0.916015625}, {"start": 1067.76, "end": 1068.12, "word": " words.", "probability": 0.79443359375}, {"start": 1070.3, "end": 1071.14, "word": " Okay.", "probability": 0.30126953125}, {"start": 1078.38, "end": 1079.22, "word": " We", "probability": 0.91259765625}, {"start": 1079.22, "end": 1079.5, "word": " don't", "probability": 0.978271484375}, {"start": 1079.5, "end": 1080.0, "word": " have", "probability": 0.9541015625}, {"start": 1080.0, "end": 1081.18, "word": " the", "probability": 0.84521484375}, {"start": 1081.18, "end": 1081.6, "word": " Hamza", "probability": 0.82421875}, {"start": 1081.6, "end": 1081.98, "word": " in", "probability": 0.951171875}, {"start": 1081.98, "end": 1082.36, "word": " English,", "probability": 0.97900390625}, {"start": 1083.02, "end": 1083.12, "word": " the", "probability": 0.90771484375}, {"start": 1083.12, "end": 1083.5, "word": " glottal", "probability": 0.9306640625}, {"start": 1083.5, "end": 1083.9, "word": " sound.", "probability": 0.87646484375}], "temperature": 1.0}, {"id": 40, "seek": 111230, "start": 1084.74, "end": 1112.3, "text": " The only glottal sound in English is the H sound. So we don't have the H sound which is only available in Arabic. So it is allow, attack, collapse, command, comment, illegal, connect. You see? So this is a rich area of interlingual errors.", "tokens": [440, 787, 1563, 1521, 304, 1626, 294, 3669, 307, 264, 389, 1626, 13, 407, 321, 500, 380, 362, 264, 389, 1626, 597, 307, 787, 2435, 294, 19938, 13, 407, 309, 307, 2089, 11, 2690, 11, 15584, 11, 5622, 11, 2871, 11, 11905, 11, 1745, 13, 509, 536, 30, 407, 341, 307, 257, 4593, 1859, 295, 728, 1688, 901, 13603, 13], "avg_logprob": -0.1404969223210069, "compression_ratio": 1.4545454545454546, "no_speech_prob": 0.0, "words": [{"start": 1084.74, "end": 1084.96, "word": " The", "probability": 0.806640625}, {"start": 1084.96, "end": 1085.24, "word": " only", "probability": 0.9140625}, {"start": 1085.24, "end": 1085.58, "word": " glottal", "probability": 0.9461263020833334}, {"start": 1085.58, "end": 1085.96, "word": " sound", "probability": 0.8671875}, {"start": 1085.96, "end": 1086.78, "word": " in", "probability": 0.9423828125}, {"start": 1086.78, "end": 1087.12, "word": " English", "probability": 0.97607421875}, {"start": 1087.12, "end": 1087.44, "word": " is", "probability": 0.943359375}, {"start": 1087.44, "end": 1087.62, "word": " the", "probability": 0.85205078125}, {"start": 1087.62, "end": 1087.72, "word": " H", "probability": 0.210693359375}, {"start": 1087.72, "end": 1088.08, "word": " sound.", "probability": 0.841796875}, {"start": 1088.76, "end": 1089.16, "word": " So", "probability": 0.904296875}, {"start": 1089.16, "end": 1089.3, "word": " we", "probability": 0.58642578125}, {"start": 1089.3, "end": 1089.48, "word": " don't", "probability": 0.96533203125}, {"start": 1089.48, "end": 1089.88, "word": " have", "probability": 0.95068359375}, {"start": 1089.88, "end": 1090.28, "word": " the", "probability": 0.919921875}, {"start": 1090.28, "end": 1090.48, "word": " H", "probability": 0.360107421875}, {"start": 1090.48, "end": 1090.86, "word": " sound", "probability": 0.89013671875}, {"start": 1090.86, "end": 1091.1, "word": " which", "probability": 0.55712890625}, {"start": 1091.1, "end": 1091.3, "word": " is", "probability": 0.9521484375}, {"start": 1091.3, "end": 1091.62, "word": " only", "probability": 0.93408203125}, {"start": 1091.62, "end": 1092.06, "word": " available", "probability": 0.83056640625}, {"start": 1092.06, "end": 1092.36, "word": " in", "probability": 0.95654296875}, {"start": 1092.36, "end": 1092.66, "word": " Arabic.", "probability": 0.923828125}, {"start": 1093.38, "end": 1093.54, "word": " So", "probability": 0.91552734375}, {"start": 1093.54, "end": 1093.72, "word": " it", "probability": 0.9091796875}, {"start": 1093.72, "end": 1094.2, "word": " is", "probability": 0.94287109375}, {"start": 1094.2, "end": 1094.76, "word": " allow,", "probability": 0.71630859375}, {"start": 1095.66, "end": 1096.34, "word": " attack,", "probability": 0.95166015625}, {"start": 1097.04, "end": 1097.58, "word": " collapse,", "probability": 0.91259765625}, {"start": 1098.28, "end": 1098.72, "word": " command,", "probability": 0.93505859375}, {"start": 1099.5, "end": 1100.0, "word": " comment,", "probability": 0.7431640625}, {"start": 1100.68, "end": 1101.12, "word": " illegal,", "probability": 0.93212890625}, {"start": 1101.9, "end": 1102.4, "word": " connect.", "probability": 0.943359375}, {"start": 1105.6, "end": 1106.4, "word": " You", "probability": 0.70458984375}, {"start": 1106.4, "end": 1106.56, "word": " see?", "probability": 0.92822265625}, {"start": 1107.58, "end": 1107.9, "word": " So", "probability": 0.95458984375}, {"start": 1107.9, "end": 1108.1, "word": " this", "probability": 0.89794921875}, {"start": 1108.1, "end": 1108.66, "word": " is", "probability": 0.94677734375}, {"start": 1108.66, "end": 1109.54, "word": " a", "probability": 0.98681640625}, {"start": 1109.54, "end": 1109.8, "word": " rich", "probability": 0.88134765625}, {"start": 1109.8, "end": 1110.26, "word": " area", "probability": 0.89794921875}, {"start": 1110.26, "end": 1110.84, "word": " of", "probability": 0.97216796875}, {"start": 1110.84, "end": 1112.06, "word": " interlingual", "probability": 0.9142252604166666}, {"start": 1112.06, "end": 1112.3, "word": " errors.", "probability": 0.7265625}], "temperature": 1.0}, {"id": 41, "seek": 114175, "start": 1118.87, "end": 1141.75, "text": " So, you have to be careful just in consonant doubling. You have to be careful in the clusterization system. You have to be careful in teaching the alveolar sounds, the dental sounds, and other consonants which are not available in Arabic.", "tokens": [407, 11, 291, 362, 281, 312, 5026, 445, 294, 43647, 33651, 13, 509, 362, 281, 312, 5026, 294, 264, 13630, 2144, 1185, 13, 509, 362, 281, 312, 5026, 294, 4571, 264, 419, 303, 15276, 3263, 11, 264, 24473, 3263, 11, 293, 661, 30843, 1719, 597, 366, 406, 2435, 294, 19938, 13], "avg_logprob": -0.12026742688165261, "compression_ratio": 1.6950354609929077, "no_speech_prob": 0.0, "words": [{"start": 1118.87, "end": 1119.59, "word": " So,", "probability": 0.87158203125}, {"start": 1119.59, "end": 1120.31, "word": " you", "probability": 0.96923828125}, {"start": 1120.31, "end": 1120.49, "word": " have", "probability": 0.94970703125}, {"start": 1120.49, "end": 1120.59, "word": " to", "probability": 0.9765625}, {"start": 1120.59, "end": 1120.75, "word": " be", "probability": 0.9619140625}, {"start": 1120.75, "end": 1121.11, "word": " careful", "probability": 0.96875}, {"start": 1121.11, "end": 1122.37, "word": " just", "probability": 0.80859375}, {"start": 1122.37, "end": 1122.65, "word": " in", "probability": 0.94287109375}, {"start": 1122.65, "end": 1123.01, "word": " consonant", "probability": 0.86279296875}, {"start": 1123.01, "end": 1123.41, "word": " doubling.", "probability": 0.955078125}, {"start": 1124.19, "end": 1124.73, "word": " You", "probability": 0.9658203125}, {"start": 1124.73, "end": 1124.87, "word": " have", "probability": 0.95068359375}, {"start": 1124.87, "end": 1124.99, "word": " to", "probability": 0.97412109375}, {"start": 1124.99, "end": 1125.15, "word": " be", "probability": 0.96044921875}, {"start": 1125.15, "end": 1125.51, "word": " careful", "probability": 0.96728515625}, {"start": 1125.51, "end": 1125.87, "word": " in", "probability": 0.94873046875}, {"start": 1125.87, "end": 1125.99, "word": " the", "probability": 0.91796875}, {"start": 1125.99, "end": 1126.71, "word": " clusterization", "probability": 0.5179443359375}, {"start": 1126.71, "end": 1127.29, "word": " system.", "probability": 0.951171875}, {"start": 1128.29, "end": 1128.49, "word": " You", "probability": 0.9619140625}, {"start": 1128.49, "end": 1128.67, "word": " have", "probability": 0.9501953125}, {"start": 1128.67, "end": 1128.77, "word": " to", "probability": 0.97412109375}, {"start": 1128.77, "end": 1128.93, "word": " be", "probability": 0.9619140625}, {"start": 1128.93, "end": 1129.35, "word": " careful", "probability": 0.9677734375}, {"start": 1129.35, "end": 1129.79, "word": " in", "probability": 0.9462890625}, {"start": 1129.79, "end": 1130.29, "word": " teaching", "probability": 0.9033203125}, {"start": 1130.29, "end": 1130.57, "word": " the", "probability": 0.93212890625}, {"start": 1130.57, "end": 1131.15, "word": " alveolar", "probability": 0.9845377604166666}, {"start": 1131.15, "end": 1131.71, "word": " sounds,", "probability": 0.869140625}, {"start": 1133.31, "end": 1133.63, "word": " the", "probability": 0.90869140625}, {"start": 1133.63, "end": 1134.67, "word": " dental", "probability": 0.92578125}, {"start": 1134.67, "end": 1136.51, "word": " sounds,", "probability": 0.830078125}, {"start": 1138.21, "end": 1138.23, "word": " and", "probability": 0.9404296875}, {"start": 1138.23, "end": 1138.93, "word": " other", "probability": 0.88525390625}, {"start": 1138.93, "end": 1139.51, "word": " consonants", "probability": 0.970947265625}, {"start": 1139.51, "end": 1139.73, "word": " which", "probability": 0.77734375}, {"start": 1139.73, "end": 1139.93, "word": " are", "probability": 0.9443359375}, {"start": 1139.93, "end": 1140.11, "word": " not", "probability": 0.94970703125}, {"start": 1140.11, "end": 1140.57, "word": " available", "probability": 0.84912109375}, {"start": 1140.57, "end": 1141.41, "word": " in", "probability": 0.9521484375}, {"start": 1141.41, "end": 1141.75, "word": " Arabic.", "probability": 0.90673828125}], "temperature": 1.0}, {"id": 42, "seek": 117183, "start": 1142.57, "end": 1171.83, "text": " Arabic, as I mentioned last time, is a semantic language, while English is an Indo-European language. There is no similarity, there is no symmetry between the two languages. We assume that they are different in all aspects of linguistics, either grammar, syntax, sociolinguistics, pronunciation, etc.", "tokens": [19938, 11, 382, 286, 2835, 1036, 565, 11, 307, 257, 47982, 2856, 11, 1339, 3669, 307, 364, 46489, 12, 32293, 282, 2856, 13, 821, 307, 572, 32194, 11, 456, 307, 572, 25440, 1296, 264, 732, 8650, 13, 492, 6552, 300, 436, 366, 819, 294, 439, 7270, 295, 21766, 6006, 11, 2139, 22317, 11, 28431, 11, 3075, 401, 7050, 6006, 11, 23338, 11, 5183, 13], "avg_logprob": -0.14795673076923077, "compression_ratio": 1.5435897435897437, "no_speech_prob": 0.0, "words": [{"start": 1142.57, "end": 1143.29, "word": " Arabic,", "probability": 0.51220703125}, {"start": 1143.61, "end": 1143.75, "word": " as", "probability": 0.96337890625}, {"start": 1143.75, "end": 1143.89, "word": " I", "probability": 0.990234375}, {"start": 1143.89, "end": 1144.21, "word": " mentioned", "probability": 0.81689453125}, {"start": 1144.21, "end": 1144.53, "word": " last", "probability": 0.84619140625}, {"start": 1144.53, "end": 1144.89, "word": " time,", "probability": 0.888671875}, {"start": 1145.25, "end": 1145.59, "word": " is", "probability": 0.9521484375}, {"start": 1145.59, "end": 1145.73, "word": " a", "probability": 0.99462890625}, {"start": 1145.73, "end": 1146.01, "word": " semantic", "probability": 0.689453125}, {"start": 1146.01, "end": 1146.65, "word": " language,", "probability": 0.8681640625}, {"start": 1147.11, "end": 1147.59, "word": " while", "probability": 0.90673828125}, {"start": 1147.59, "end": 1148.11, "word": " English", "probability": 0.9775390625}, {"start": 1148.11, "end": 1148.47, "word": " is", "probability": 0.9521484375}, {"start": 1148.47, "end": 1148.61, "word": " an", "probability": 0.51806640625}, {"start": 1148.61, "end": 1148.79, "word": " Indo", "probability": 0.931640625}, {"start": 1148.79, "end": 1149.35, "word": "-European", "probability": 0.9236653645833334}, {"start": 1149.35, "end": 1149.77, "word": " language.", "probability": 0.857421875}, {"start": 1149.93, "end": 1150.05, "word": " There", "probability": 0.7587890625}, {"start": 1150.05, "end": 1150.63, "word": " is", "probability": 0.86474609375}, {"start": 1150.63, "end": 1150.95, "word": " no", "probability": 0.94482421875}, {"start": 1150.95, "end": 1152.09, "word": " similarity,", "probability": 0.9306640625}, {"start": 1153.03, "end": 1153.43, "word": " there", "probability": 0.8544921875}, {"start": 1153.43, "end": 1153.55, "word": " is", "probability": 0.91455078125}, {"start": 1153.55, "end": 1153.91, "word": " no", "probability": 0.96484375}, {"start": 1153.91, "end": 1154.47, "word": " symmetry", "probability": 0.923828125}, {"start": 1154.47, "end": 1154.87, "word": " between", "probability": 0.86376953125}, {"start": 1154.87, "end": 1155.09, "word": " the", "probability": 0.9208984375}, {"start": 1155.09, "end": 1155.25, "word": " two", "probability": 0.93115234375}, {"start": 1155.25, "end": 1155.75, "word": " languages.", "probability": 0.9658203125}, {"start": 1157.65, "end": 1158.45, "word": " We", "probability": 0.962890625}, {"start": 1158.45, "end": 1158.91, "word": " assume", "probability": 0.89208984375}, {"start": 1158.91, "end": 1159.15, "word": " that", "probability": 0.90478515625}, {"start": 1159.15, "end": 1159.29, "word": " they", "probability": 0.896484375}, {"start": 1159.29, "end": 1159.47, "word": " are", "probability": 0.94091796875}, {"start": 1159.47, "end": 1160.03, "word": " different", "probability": 0.89208984375}, {"start": 1160.03, "end": 1160.81, "word": " in", "probability": 0.9208984375}, {"start": 1160.81, "end": 1161.37, "word": " all", "probability": 0.9521484375}, {"start": 1161.37, "end": 1162.31, "word": " aspects", "probability": 0.849609375}, {"start": 1162.31, "end": 1163.07, "word": " of", "probability": 0.97119140625}, {"start": 1163.07, "end": 1163.77, "word": " linguistics,", "probability": 0.96142578125}, {"start": 1164.37, "end": 1164.61, "word": " either", "probability": 0.90185546875}, {"start": 1164.61, "end": 1165.01, "word": " grammar,", "probability": 0.91845703125}, {"start": 1166.03, "end": 1166.37, "word": " syntax,", "probability": 0.96923828125}, {"start": 1168.43, "end": 1169.35, "word": " sociolinguistics,", "probability": 0.84375}, {"start": 1169.99, "end": 1170.71, "word": " pronunciation,", "probability": 0.935546875}, {"start": 1171.49, "end": 1171.83, "word": " etc.", "probability": 0.6279296875}], "temperature": 1.0}, {"id": 43, "seek": 119997, "start": 1173.03, "end": 1199.97, "text": " There is no relevance between Arabic and English in any point of these. You have to take care to understand your English very well and not to compare it with your Arabic except only for the sake of comparison or contrastive linguistics or etc. Now we shift to what is called vowels of English.", "tokens": [821, 307, 572, 32684, 1296, 19938, 293, 3669, 294, 604, 935, 295, 613, 13, 509, 362, 281, 747, 1127, 281, 1223, 428, 3669, 588, 731, 293, 406, 281, 6794, 309, 365, 428, 19938, 3993, 787, 337, 264, 9717, 295, 9660, 420, 8712, 488, 21766, 6006, 420, 5183, 13, 823, 321, 5513, 281, 437, 307, 1219, 44972, 295, 3669, 13], "avg_logprob": -0.11835937214394411, "compression_ratio": 1.53125, "no_speech_prob": 0.0, "words": [{"start": 1173.03, "end": 1173.27, "word": " There", "probability": 0.58251953125}, {"start": 1173.27, "end": 1173.39, "word": " is", "probability": 0.84912109375}, {"start": 1173.39, "end": 1173.57, "word": " no", "probability": 0.958984375}, {"start": 1173.57, "end": 1174.07, "word": " relevance", "probability": 0.92724609375}, {"start": 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How many short vowels do we have in Arabic? Three short vowels. Nominative, accusative, genitive. However, in English, how many? We have seven short vowels. So this means that", "tokens": [509, 458, 11, 321, 362, 2099, 44972, 11, 938, 44972, 11, 10460, 357, 71, 42478, 11, 293, 1376, 79, 357, 71, 42478, 13, 1012, 867, 2099, 44972, 360, 321, 362, 294, 19938, 30, 6244, 2099, 44972, 13, 426, 6981, 1166, 11, 11168, 1166, 11, 1049, 2187, 13, 2908, 11, 294, 3669, 11, 577, 867, 30, 492, 362, 3407, 2099, 44972, 13, 407, 341, 1355, 300], "avg_logprob": -0.1228693172787175, "compression_ratio": 1.644736842105263, "no_speech_prob": 0.0, "words": [{"start": 1201.25, "end": 1201.45, "word": " You", "probability": 0.734375}, {"start": 1201.45, "end": 1201.57, "word": " know,", "probability": 0.90478515625}, {"start": 1201.65, "end": 1201.75, "word": " we", "probability": 0.962890625}, {"start": 1201.75, "end": 1201.95, "word": " have", "probability": 0.94775390625}, {"start": 1201.95, "end": 1202.33, "word": " short", "probability": 0.96337890625}, {"start": 1202.33, "end": 1202.75, "word": " vowels,", "probability": 0.9765625}, {"start": 1203.45, "end": 1203.73, "word": " long", "probability": 0.92919921875}, {"start": 1203.73, "end": 1204.29, "word": " vowels,", "probability": 0.984375}, {"start": 1204.97, "end": 1205.45, "word": " diphthongs,", "probability": 0.92431640625}, {"start": 1206.17, "end": 1206.43, "word": " and", "probability": 0.94970703125}, {"start": 1206.43, "end": 1206.93, "word": " triphthongs.", "probability": 0.742724609375}, {"start": 1208.41, "end": 1209.17, "word": " How", "probability": 0.96337890625}, {"start": 1209.17, "end": 1209.39, "word": " many", "probability": 0.90673828125}, {"start": 1209.39, "end": 1209.69, "word": " short", "probability": 0.9580078125}, {"start": 1209.69, "end": 1209.93, "word": " vowels", "probability": 0.982421875}, {"start": 1209.93, "end": 1210.11, "word": " do", "probability": 0.9638671875}, {"start": 1210.11, "end": 1210.23, "word": " we", "probability": 0.96337890625}, {"start": 1210.23, "end": 1210.45, "word": " have", "probability": 0.9462890625}, {"start": 1210.45, "end": 1210.59, "word": " in", "probability": 0.9521484375}, {"start": 1210.59, "end": 1210.85, "word": " Arabic?", "probability": 0.90380859375}, {"start": 1213.53, "end": 1214.29, "word": " Three", "probability": 0.84033203125}, {"start": 1214.29, "end": 1214.73, "word": " short", "probability": 0.94189453125}, {"start": 1214.73, "end": 1215.13, "word": " vowels.", "probability": 0.9873046875}, {"start": 1215.89, "end": 1216.51, "word": " Nominative,", "probability": 0.955078125}, {"start": 1216.73, "end": 1217.49, "word": " accusative,", "probability": 0.975830078125}, {"start": 1217.71, "end": 1218.15, "word": " genitive.", "probability": 0.936279296875}, {"start": 1219.37, "end": 1219.75, "word": " However,", "probability": 0.880859375}, {"start": 1219.91, "end": 1220.09, "word": " in", "probability": 0.9521484375}, {"start": 1220.09, "end": 1220.49, "word": " English,", "probability": 0.97607421875}, {"start": 1221.23, "end": 1221.53, "word": " how", "probability": 0.8955078125}, {"start": 1221.53, "end": 1221.81, "word": " many?", "probability": 0.8994140625}, {"start": 1222.49, "end": 1222.75, "word": " We", "probability": 0.96337890625}, {"start": 1222.75, "end": 1222.95, "word": " have", "probability": 0.94921875}, {"start": 1222.95, "end": 1223.31, "word": " seven", "probability": 0.87158203125}, {"start": 1223.31, "end": 1224.65, "word": " short", "probability": 0.83935546875}, {"start": 1224.65, "end": 1225.09, "word": " vowels.", "probability": 0.986328125}, {"start": 1225.49, "end": 1225.89, "word": " So", "probability": 0.9560546875}, {"start": 1225.89, "end": 1226.07, "word": " this", "probability": 0.63623046875}, {"start": 1226.07, "end": 1226.43, "word": " means", "probability": 0.93017578125}, {"start": 1226.43, "end": 1226.93, "word": " that", "probability": 0.93798828125}], "temperature": 1.0}, {"id": 45, "seek": 125320, "start": 1227.6, "end": 1253.2, "text": " We are in front of a big dilemma. This is represented in pronouncing these short vowels. Our students mix between them and produce intralingual errors resulting from the difficulty of English. So we have the first short vowel that is", "tokens": [492, 366, 294, 1868, 295, 257, 955, 34312, 13, 639, 307, 10379, 294, 14144, 2175, 613, 2099, 44972, 13, 2621, 1731, 2890, 1296, 552, 293, 5258, 43358, 1688, 901, 13603, 16505, 490, 264, 10360, 295, 3669, 13, 407, 321, 362, 264, 700, 2099, 29410, 300, 307], "avg_logprob": -0.149601068268431, "compression_ratio": 1.453416149068323, "no_speech_prob": 0.0, "words": [{"start": 1227.6, "end": 1228.02, "word": " We", "probability": 0.65576171875}, {"start": 1228.02, "end": 1228.56, "word": " are", "probability": 0.94287109375}, {"start": 1228.56, "end": 1229.14, "word": " in", "probability": 0.94921875}, {"start": 1229.14, "end": 1229.56, "word": " front", "probability": 0.96142578125}, {"start": 1229.56, "end": 1230.1, "word": " of", "probability": 0.9716796875}, {"start": 1230.1, "end": 1230.62, "word": " a", "probability": 0.99755859375}, {"start": 1230.62, "end": 1230.88, "word": " big", "probability": 0.9208984375}, {"start": 1230.88, "end": 1231.42, "word": " dilemma.", "probability": 0.8193359375}, {"start": 1232.4, "end": 1232.48, "word": " This", "probability": 0.90185546875}, {"start": 1232.48, "end": 1232.64, "word": " is", "probability": 0.95068359375}, {"start": 1232.64, "end": 1233.12, "word": " represented", "probability": 0.79541015625}, {"start": 1233.12, "end": 1233.54, "word": " in", "probability": 0.9267578125}, {"start": 1233.54, "end": 1234.24, "word": " pronouncing", "probability": 0.96044921875}, {"start": 1234.24, "end": 1234.64, "word": " these", "probability": 0.8681640625}, {"start": 1234.64, "end": 1235.02, "word": " short", "probability": 0.962890625}, {"start": 1235.02, "end": 1235.42, "word": " vowels.", "probability": 0.98681640625}, {"start": 1236.48, "end": 1236.68, "word": " Our", "probability": 0.96533203125}, {"start": 1236.68, "end": 1237.22, "word": " students", "probability": 0.97607421875}, {"start": 1237.22, "end": 1237.9, "word": " mix", "probability": 0.94189453125}, {"start": 1237.9, "end": 1238.28, "word": " between", "probability": 0.87060546875}, {"start": 1238.28, "end": 1238.66, "word": " them", "probability": 0.8974609375}, {"start": 1238.66, "end": 1239.58, "word": " and", "probability": 0.8779296875}, {"start": 1239.58, "end": 1240.22, "word": " produce", "probability": 0.84619140625}, {"start": 1240.22, "end": 1241.74, "word": " intralingual", "probability": 0.735107421875}, {"start": 1241.74, "end": 1242.2, "word": " errors", "probability": 0.85205078125}, {"start": 1242.2, "end": 1244.48, "word": " resulting", "probability": 0.5517578125}, {"start": 1244.48, "end": 1244.88, "word": " from", "probability": 0.89453125}, {"start": 1244.88, "end": 1245.12, "word": " the", "probability": 0.9267578125}, {"start": 1245.12, "end": 1245.66, "word": " difficulty", "probability": 0.71728515625}, {"start": 1245.66, "end": 1246.04, "word": " of", "probability": 0.96484375}, {"start": 1246.04, "end": 1246.44, "word": " English.", "probability": 0.98046875}, {"start": 1247.12, "end": 1247.78, "word": " So", "probability": 0.92041015625}, {"start": 1247.78, "end": 1247.92, "word": " we", "probability": 0.7001953125}, {"start": 1247.92, "end": 1248.14, "word": " have", "probability": 0.94873046875}, {"start": 1248.14, "end": 1248.32, "word": " the", "probability": 0.92041015625}, {"start": 1248.32, "end": 1248.7, "word": " first", "probability": 0.890625}, {"start": 1248.7, "end": 1249.12, "word": " short", "probability": 0.9580078125}, {"start": 1249.12, "end": 1249.48, "word": " vowel", "probability": 0.97509765625}, {"start": 1249.48, "end": 1252.82, "word": " that", "probability": 0.365966796875}, {"start": 1252.82, "end": 1253.2, "word": " is", "probability": 0.9521484375}], "temperature": 1.0}, {"id": 46, "seek": 128383, "start": 1254.45, "end": 1283.83, "text": " As available in hit, set, sex. These words contain the short vowel, as in hit, lip, sex, set.", "tokens": [1018, 2435, 294, 2045, 11, 992, 11, 3260, 13, 1981, 2283, 5304, 264, 2099, 29410, 11, 382, 294, 2045, 11, 8280, 11, 3260, 11, 992, 13], "avg_logprob": -0.2517361243565877, "compression_ratio": 1.1604938271604939, "no_speech_prob": 0.0, "words": [{"start": 1254.45, "end": 1255.23, "word": " As", "probability": 0.501953125}, {"start": 1255.23, "end": 1256.51, "word": " available", "probability": 0.2249755859375}, {"start": 1256.51, "end": 1257.07, "word": " in", "probability": 0.94482421875}, {"start": 1257.07, "end": 1257.55, "word": " hit,", "probability": 0.72119140625}, {"start": 1259.07, "end": 1259.43, "word": " set,", "probability": 0.95263671875}, {"start": 1260.51, "end": 1260.95, "word": " sex.", "probability": 0.47998046875}, {"start": 1263.03, "end": 1264.43, "word": " These", "probability": 0.91845703125}, {"start": 1264.43, "end": 1264.89, "word": " words", "probability": 0.865234375}, {"start": 1264.89, "end": 1266.73, "word": " contain", "probability": 0.71044921875}, {"start": 1266.73, "end": 1268.09, "word": " the", "probability": 0.8486328125}, {"start": 1268.09, "end": 1268.59, "word": " short", "probability": 0.9658203125}, {"start": 1268.59, "end": 1269.81, "word": " vowel,", "probability": 0.9580078125}, {"start": 1270.71, "end": 1272.49, "word": " as", "probability": 0.61474609375}, {"start": 1272.49, "end": 1273.59, "word": " in", "probability": 0.95068359375}, {"start": 1273.59, "end": 1275.09, "word": " hit,", "probability": 0.8193359375}, {"start": 1277.09, "end": 1277.61, "word": " lip,", "probability": 0.75244140625}, {"start": 1281.67, "end": 1282.07, "word": " sex,", "probability": 0.8876953125}, {"start": 1283.49, "end": 1283.83, "word": " set.", "probability": 0.9716796875}], "temperature": 1.0}, {"id": 47, "seek": 131562, "start": 1286.28, "end": 1315.62, "text": " Okay. Now this vowel is problematic because our students commit or confuse in pronouncing it with the eh sound. Eh sound as in set, sex, pen. There's a big difference in pronunciation between pen and pen. Sex and sex. Okay.", "tokens": [1033, 13, 823, 341, 29410, 307, 19011, 570, 527, 1731, 5599, 420, 28584, 294, 14144, 2175, 309, 365, 264, 7670, 1626, 13, 9663, 1626, 382, 294, 992, 11, 3260, 11, 3435, 13, 821, 311, 257, 955, 2649, 294, 23338, 1296, 3435, 293, 3435, 13, 29037, 293, 3260, 13, 1033, 13], "avg_logprob": -0.18964460959621504, "compression_ratio": 1.4177215189873418, "no_speech_prob": 0.0, "words": [{"start": 1286.28, "end": 1286.64, "word": " Okay.", "probability": 0.73046875}, {"start": 1287.24, "end": 1287.74, "word": " Now", "probability": 0.9658203125}, {"start": 1287.74, "end": 1288.0, "word": " this", "probability": 0.68359375}, {"start": 1288.0, "end": 1288.38, "word": " vowel", "probability": 0.966796875}, {"start": 1288.38, "end": 1290.26, "word": " is", "probability": 0.86376953125}, {"start": 1290.26, "end": 1291.56, "word": " problematic", "probability": 0.8798828125}, {"start": 1291.56, "end": 1292.3, "word": " because", "probability": 0.87451171875}, {"start": 1292.3, "end": 1293.32, "word": " our", "probability": 0.88623046875}, {"start": 1293.32, "end": 1293.92, "word": " students", "probability": 0.97509765625}, {"start": 1293.92, "end": 1294.48, "word": " commit", "probability": 0.85107421875}, {"start": 1294.48, "end": 1294.78, "word": " or", "probability": 0.93310546875}, {"start": 1294.78, "end": 1295.42, "word": " confuse", "probability": 0.63671875}, {"start": 1295.42, "end": 1295.74, "word": " in", "probability": 0.912109375}, {"start": 1295.74, "end": 1296.34, "word": " pronouncing", "probability": 0.958984375}, {"start": 1296.34, "end": 1296.68, "word": " it", "probability": 0.95947265625}, {"start": 1296.68, "end": 1297.18, "word": " with", "probability": 0.9033203125}, {"start": 1297.18, "end": 1297.76, "word": " the", "probability": 0.92822265625}, {"start": 1297.76, "end": 1297.96, "word": " eh", "probability": 0.1998291015625}, {"start": 1297.96, "end": 1298.46, "word": " sound.", "probability": 0.8671875}, {"start": 1298.98, "end": 1299.18, "word": " Eh", "probability": 0.9345703125}, {"start": 1299.18, "end": 1299.48, "word": " sound", "probability": 0.87353515625}, {"start": 1299.48, "end": 1299.78, "word": " as", "probability": 0.50048828125}, {"start": 1299.78, "end": 1300.44, "word": " in", "probability": 0.94970703125}, {"start": 1300.44, "end": 1301.08, "word": " set,", "probability": 0.87890625}, {"start": 1302.08, "end": 1302.64, "word": " sex,", "probability": 0.884765625}, {"start": 1304.06, "end": 1304.38, "word": " pen.", "probability": 0.82958984375}, {"start": 1306.3, "end": 1307.24, "word": " There's", "probability": 0.79150390625}, {"start": 1307.24, "end": 1307.32, "word": " a", "probability": 0.99658203125}, {"start": 1307.32, "end": 1307.46, "word": " big", "probability": 0.92138671875}, {"start": 1307.46, "end": 1307.86, "word": " difference", "probability": 0.849609375}, {"start": 1307.86, "end": 1308.02, "word": " in", "probability": 0.94287109375}, {"start": 1308.02, "end": 1308.5, "word": " pronunciation", "probability": 0.91162109375}, {"start": 1308.5, "end": 1309.04, "word": " between", "probability": 0.87060546875}, {"start": 1309.04, "end": 1309.5, "word": " pen", "probability": 0.9560546875}, {"start": 1309.5, "end": 1310.56, "word": " and", "probability": 0.9462890625}, {"start": 1310.56, "end": 1311.36, "word": " pen.", "probability": 0.5732421875}, {"start": 1312.66, "end": 1313.06, "word": " Sex", "probability": 0.93798828125}, {"start": 1313.06, "end": 1314.0, "word": " and", "probability": 0.93359375}, {"start": 1314.0, "end": 1314.62, "word": " sex.", "probability": 0.9501953125}, {"start": 1315.24, "end": 1315.62, "word": " Okay.", "probability": 0.89453125}], "temperature": 1.0}, {"id": 48, "seek": 134641, "start": 1317.35, "end": 1346.41, "text": " So any mistake in this field results from the difficulty of the pronunciation system of English. So it is called intralingual error. We have this sound available in Arabic represented in the kasra, the genitive case, okay? الولد ذهب إلى السوق", "tokens": [407, 604, 6146, 294, 341, 2519, 3542, 490, 264, 10360, 295, 264, 23338, 1185, 295, 3669, 13, 407, 309, 307, 1219, 560, 2155, 278, 901, 6713, 13, 492, 362, 341, 1626, 2435, 294, 19938, 10379, 294, 264, 19173, 424, 11, 264, 1049, 2187, 1389, 11, 1392, 30, 2423, 12610, 3215, 29910, 3224, 3555, 30731, 21136, 30543], "avg_logprob": -0.16049890978294507, "compression_ratio": 1.3015075376884422, "no_speech_prob": 0.0, "words": [{"start": 1317.35, "end": 1317.73, "word": " So", "probability": 0.9072265625}, {"start": 1317.73, "end": 1318.33, "word": " any", "probability": 0.61669921875}, {"start": 1318.33, "end": 1319.39, "word": " mistake", "probability": 0.9658203125}, {"start": 1319.39, "end": 1320.13, "word": " in", "probability": 0.9443359375}, {"start": 1320.13, "end": 1320.41, "word": " this", "probability": 0.9482421875}, {"start": 1320.41, "end": 1320.83, "word": " field", "probability": 0.94091796875}, {"start": 1320.83, "end": 1322.69, "word": " results", "probability": 0.833984375}, {"start": 1322.69, "end": 1323.03, "word": " from", "probability": 0.89892578125}, {"start": 1323.03, "end": 1323.23, "word": " the", "probability": 0.93115234375}, {"start": 1323.23, "end": 1323.71, "word": " difficulty", "probability": 0.71533203125}, {"start": 1323.71, "end": 1324.09, "word": " of", "probability": 0.97119140625}, {"start": 1324.09, "end": 1324.23, "word": " the", "probability": 0.92578125}, {"start": 1324.23, "end": 1324.67, "word": " pronunciation", "probability": 0.94580078125}, {"start": 1324.67, "end": 1326.01, "word": " system", "probability": 0.9521484375}, {"start": 1326.01, "end": 1326.21, "word": " of", "probability": 0.9716796875}, {"start": 1326.21, "end": 1326.67, "word": " English.", "probability": 0.9794921875}, {"start": 1327.09, "end": 1327.53, "word": " So", "probability": 0.95703125}, {"start": 1327.53, "end": 1327.65, "word": " it", "probability": 0.9169921875}, {"start": 1327.65, "end": 1327.81, "word": " is", "probability": 0.9375}, {"start": 1327.81, "end": 1328.17, "word": " called", "probability": 0.8857421875}, {"start": 1328.17, "end": 1329.15, "word": " intralingual", "probability": 0.7794189453125}, {"start": 1329.15, "end": 1329.89, "word": " error.", "probability": 0.88232421875}, {"start": 1331.81, "end": 1332.71, "word": " We", "probability": 0.96435546875}, {"start": 1332.71, "end": 1333.17, "word": " have", "probability": 0.94970703125}, {"start": 1333.17, "end": 1334.65, "word": " this", "probability": 0.93359375}, {"start": 1334.65, "end": 1334.97, "word": " sound", "probability": 0.8837890625}, {"start": 1334.97, "end": 1335.39, "word": " available", "probability": 0.86328125}, {"start": 1335.39, "end": 1335.67, "word": " in", "probability": 0.9541015625}, {"start": 1335.67, "end": 1336.07, "word": " Arabic", "probability": 0.9013671875}, {"start": 1336.07, "end": 1337.01, "word": " represented", "probability": 0.568359375}, {"start": 1337.01, "end": 1337.57, "word": " in", "probability": 0.95068359375}, {"start": 1337.57, "end": 1337.89, "word": " the", "probability": 0.923828125}, {"start": 1337.89, "end": 1338.25, "word": " kasra,", "probability": 0.5836181640625}, {"start": 1339.17, "end": 1339.31, "word": " the", "probability": 0.92138671875}, {"start": 1339.31, "end": 1339.71, "word": " genitive", "probability": 0.90380859375}, {"start": 1339.71, "end": 1340.17, "word": " case,", "probability": 0.92919921875}, {"start": 1340.87, "end": 1341.15, "word": " okay?", "probability": 0.88134765625}, {"start": 1343.07, "end": 1343.83, "word": " الولد", "probability": 0.8603515625}, {"start": 1343.83, "end": 1345.03, "word": " ذهب", "probability": 0.98974609375}, {"start": 1345.03, "end": 1345.87, "word": " إلى", "probability": 0.8427734375}, {"start": 1345.87, "end": 1346.41, "word": " السوق", "probability": 0.941650390625}], "temperature": 1.0}, {"id": 49, "seek": 137225, "start": 1350.41, "end": 1372.25, "text": " It appears in what is called constructed states. So the constructed state is always assigned genitive case in English, completely like Arabic.", "tokens": [467, 7038, 294, 437, 307, 1219, 17083, 4368, 13, 407, 264, 17083, 1785, 307, 1009, 13279, 1049, 2187, 1389, 294, 3669, 11, 2584, 411, 19938, 13], "avg_logprob": -0.2826967614668387, "compression_ratio": 1.2882882882882882, "no_speech_prob": 0.0, "words": [{"start": 1350.41, "end": 1351.41, "word": " It", "probability": 0.300537109375}, {"start": 1351.41, "end": 1352.41, "word": " appears", "probability": 0.70556640625}, {"start": 1352.41, "end": 1352.77, "word": " in", "probability": 0.939453125}, {"start": 1352.77, "end": 1352.91, "word": " what", "probability": 0.93017578125}, {"start": 1352.91, "end": 1353.09, "word": " is", "probability": 0.61083984375}, {"start": 1353.09, "end": 1353.39, "word": " called", "probability": 0.9130859375}, {"start": 1353.39, "end": 1354.01, "word": " constructed", "probability": 0.5615234375}, {"start": 1354.01, "end": 1354.59, "word": " states.", "probability": 0.83203125}, {"start": 1356.89, "end": 1357.89, "word": " So", "probability": 0.315185546875}, {"start": 1357.89, "end": 1365.25, "word": " the", "probability": 0.732421875}, {"start": 1365.25, "end": 1365.69, "word": " constructed", "probability": 0.89404296875}, {"start": 1365.69, "end": 1366.11, "word": " state", "probability": 0.8935546875}, {"start": 1366.11, "end": 1366.29, "word": " is", "probability": 0.9326171875}, {"start": 1366.29, "end": 1366.65, "word": " always", "probability": 0.90380859375}, {"start": 1366.65, "end": 1367.15, "word": " assigned", "probability": 0.74755859375}, {"start": 1367.15, "end": 1367.63, "word": " genitive", "probability": 0.726318359375}, {"start": 1367.63, "end": 1368.13, "word": " case", "probability": 0.9189453125}, {"start": 1368.13, "end": 1368.95, "word": " in", "probability": 0.9375}, {"start": 1368.95, "end": 1369.31, "word": " English,", "probability": 0.97607421875}, {"start": 1369.93, "end": 1370.45, "word": " completely", "probability": 0.69970703125}, {"start": 1370.45, "end": 1370.93, "word": " like", "probability": 0.921875}, {"start": 1370.93, "end": 1372.25, "word": " Arabic.", "probability": 0.736328125}], "temperature": 1.0}, {"id": 50, "seek": 140595, "start": 1377.25, "end": 1405.95, "text": " I say, for example, John's book. But the mechanism of assigning case or assigning genitive case to English possessive noun is different from Arabic. The genitive case is assigned by the apostrophe S. John's book. John is the possessor here. However, in Arabic, I say, Kitab-u Ahmed.", "tokens": [286, 584, 11, 337, 1365, 11, 2619, 311, 1446, 13, 583, 264, 7513, 295, 49602, 1389, 420, 49602, 1049, 2187, 1389, 281, 3669, 17490, 488, 23307, 307, 819, 490, 19938, 13, 440, 1049, 2187, 1389, 307, 13279, 538, 264, 19484, 27194, 318, 13, 2619, 311, 1446, 13, 2619, 307, 264, 17490, 284, 510, 13, 2908, 11, 294, 19938, 11, 286, 584, 11, 23037, 455, 12, 84, 39189, 13], "avg_logprob": -0.15658967823222064, "compression_ratio": 1.5297297297297296, "no_speech_prob": 0.0, "words": [{"start": 1377.25, "end": 1377.51, "word": " I", "probability": 0.92578125}, {"start": 1377.51, "end": 1377.87, "word": " say,", "probability": 0.92529296875}, {"start": 1378.29, "end": 1378.39, "word": " for", "probability": 0.94873046875}, {"start": 1378.39, "end": 1378.75, "word": " example,", "probability": 0.97119140625}, {"start": 1378.91, "end": 1379.33, "word": " John's", "probability": 0.7066650390625}, {"start": 1379.33, "end": 1379.67, "word": " book.", "probability": 0.767578125}, {"start": 1380.79, "end": 1381.15, "word": " But", "probability": 0.92822265625}, {"start": 1381.15, "end": 1381.77, "word": " the", "probability": 0.89404296875}, {"start": 1381.77, "end": 1382.93, "word": " mechanism", "probability": 0.94287109375}, {"start": 1382.93, "end": 1383.57, "word": " of", "probability": 0.9716796875}, {"start": 1383.57, "end": 1384.67, "word": " assigning", "probability": 0.91259765625}, {"start": 1384.67, "end": 1385.23, "word": " case", "probability": 0.87255859375}, {"start": 1385.23, "end": 1385.43, "word": " or", "probability": 0.60205078125}, {"start": 1385.43, "end": 1385.83, "word": " assigning", "probability": 0.88330078125}, {"start": 1385.83, "end": 1386.31, "word": " genitive", "probability": 0.92431640625}, {"start": 1386.31, "end": 1386.77, "word": " case", "probability": 0.92822265625}, {"start": 1386.77, "end": 1387.65, "word": " to", "probability": 0.923828125}, {"start": 1387.65, "end": 1388.29, "word": " English", "probability": 0.9619140625}, {"start": 1388.29, "end": 1389.67, "word": " possessive", "probability": 0.957763671875}, {"start": 1389.67, "end": 1391.09, "word": " noun", "probability": 0.966796875}, {"start": 1391.09, "end": 1392.13, "word": " is", "probability": 0.8818359375}, {"start": 1392.13, "end": 1392.61, "word": " different", "probability": 0.8935546875}, {"start": 1392.61, "end": 1393.33, "word": " from", "probability": 0.884765625}, {"start": 1393.33, "end": 1393.69, "word": " Arabic.", "probability": 0.923828125}, {"start": 1394.75, "end": 1394.99, "word": " The", "probability": 0.89306640625}, {"start": 1394.99, "end": 1395.41, "word": " genitive", "probability": 0.934814453125}, {"start": 1395.41, "end": 1395.75, "word": " case", "probability": 0.919921875}, {"start": 1395.75, "end": 1395.91, "word": " is", "probability": 0.94677734375}, {"start": 1395.91, "end": 1396.41, "word": " assigned", "probability": 0.8681640625}, {"start": 1396.41, "end": 1396.69, "word": " by", "probability": 0.97216796875}, {"start": 1396.69, "end": 1396.87, "word": " the", "probability": 0.91650390625}, {"start": 1396.87, "end": 1397.29, "word": " apostrophe", "probability": 0.84130859375}, {"start": 1397.29, "end": 1397.69, "word": " S.", "probability": 0.60693359375}, {"start": 1398.77, "end": 1399.49, "word": " John's", "probability": 0.9189453125}, {"start": 1399.49, "end": 1399.85, "word": " book.", "probability": 0.93212890625}, {"start": 1401.45, "end": 1401.73, "word": " John", "probability": 0.83544921875}, {"start": 1401.73, "end": 1401.89, "word": " is", "probability": 0.92578125}, {"start": 1401.89, "end": 1402.09, "word": " the", "probability": 0.9052734375}, {"start": 1402.09, "end": 1403.19, "word": " possessor", "probability": 0.93701171875}, {"start": 1403.19, "end": 1403.45, "word": " here.", "probability": 0.833984375}, {"start": 1403.85, "end": 1404.09, "word": " However,", "probability": 0.88037109375}, {"start": 1404.11, "end": 1404.29, "word": " in", "probability": 0.94970703125}, {"start": 1404.29, "end": 1404.53, "word": " Arabic,", "probability": 0.91943359375}, {"start": 1404.73, "end": 1404.87, "word": " I", "probability": 0.99560546875}, {"start": 1404.87, "end": 1405.07, "word": " say,", "probability": 0.9326171875}, {"start": 1405.17, "end": 1405.51, "word": " Kitab", "probability": 0.6817626953125}, {"start": 1405.51, "end": 1405.63, "word": "-u", "probability": 0.55859375}, {"start": 1405.63, "end": 1405.95, "word": " Ahmed.", "probability": 0.39453125}], "temperature": 1.0}, {"id": 51, "seek": 143667, "start": 1409.19, "end": 1436.67, "text": " The genitive case is assigned by what is called determiner and inflection or agreement. This has been seen in syntax last semester for those who have taken this course. I don't know whether you are familiar with that or not. Anyway, we have", "tokens": [440, 1049, 2187, 1389, 307, 13279, 538, 437, 307, 1219, 3618, 4564, 293, 1536, 5450, 420, 8106, 13, 639, 575, 668, 1612, 294, 28431, 1036, 11894, 337, 729, 567, 362, 2726, 341, 1164, 13, 286, 500, 380, 458, 1968, 291, 366, 4963, 365, 300, 420, 406, 13, 5684, 11, 321, 362], "avg_logprob": -0.1633113052409429, "compression_ratio": 1.4176470588235295, "no_speech_prob": 0.0, "words": [{"start": 1409.19, "end": 1410.03, "word": " The", "probability": 0.2744140625}, {"start": 1410.03, "end": 1410.87, "word": " genitive", "probability": 0.90576171875}, {"start": 1410.87, "end": 1411.25, "word": " case", "probability": 0.921875}, {"start": 1411.25, "end": 1411.43, "word": " is", "probability": 0.94921875}, {"start": 1411.43, "end": 1411.95, "word": " assigned", "probability": 0.8759765625}, {"start": 1411.95, "end": 1412.13, "word": " by", "probability": 0.970703125}, {"start": 1412.13, "end": 1412.31, "word": " what", "probability": 0.943359375}, {"start": 1412.31, "end": 1412.49, "word": " is", "probability": 0.94384765625}, {"start": 1412.49, "end": 1412.79, "word": " called", "probability": 0.90625}, {"start": 1412.79, "end": 1413.61, "word": " determiner", "probability": 0.830810546875}, {"start": 1413.61, "end": 1414.53, "word": " and", "probability": 0.8876953125}, {"start": 1414.53, "end": 1415.75, "word": " inflection", "probability": 0.91015625}, {"start": 1415.75, "end": 1416.45, "word": " or", "probability": 0.9169921875}, {"start": 1416.45, "end": 1417.53, "word": " agreement.", "probability": 0.9072265625}, {"start": 1418.41, "end": 1419.11, "word": " This", "probability": 0.322998046875}, {"start": 1419.11, "end": 1419.73, "word": " has", "probability": 0.8525390625}, {"start": 1419.73, "end": 1420.03, "word": " been", "probability": 0.912109375}, {"start": 1420.03, "end": 1420.53, "word": " seen", "probability": 0.95654296875}, {"start": 1420.53, "end": 1420.91, "word": " in", "probability": 0.9501953125}, {"start": 1420.91, "end": 1421.47, "word": " syntax", "probability": 0.96875}, {"start": 1421.47, "end": 1422.23, "word": " last", "probability": 0.84912109375}, {"start": 1422.23, "end": 1422.69, "word": " semester", "probability": 0.9541015625}, {"start": 1422.69, "end": 1423.51, "word": " for", "probability": 0.42578125}, {"start": 1423.51, "end": 1423.89, "word": " those", "probability": 0.87744140625}, {"start": 1423.89, "end": 1424.57, "word": " who", "probability": 0.9033203125}, {"start": 1424.57, "end": 1424.71, "word": " have", "probability": 0.943359375}, {"start": 1424.71, "end": 1425.73, "word": " taken", "probability": 0.755859375}, {"start": 1425.73, "end": 1426.09, "word": " this", "probability": 0.9453125}, {"start": 1426.09, "end": 1426.37, "word": " course.", "probability": 0.96240234375}, {"start": 1426.49, "end": 1426.51, "word": " I", "probability": 0.9736328125}, {"start": 1426.51, "end": 1426.65, "word": " don't", "probability": 0.970703125}, {"start": 1426.65, "end": 1426.81, "word": " know", "probability": 0.8798828125}, {"start": 1426.81, "end": 1426.99, "word": " whether", "probability": 0.89599609375}, {"start": 1426.99, "end": 1427.23, "word": " you", "probability": 0.9609375}, {"start": 1427.23, "end": 1427.75, "word": " are", "probability": 0.939453125}, {"start": 1427.75, "end": 1429.15, "word": " familiar", "probability": 0.81982421875}, {"start": 1429.15, "end": 1429.39, "word": " with", "probability": 0.759765625}, {"start": 1429.39, "end": 1429.63, "word": " that", "probability": 0.92626953125}, {"start": 1429.63, "end": 1429.79, "word": " or", "probability": 0.96044921875}, {"start": 1429.79, "end": 1430.07, "word": " not.", "probability": 0.9423828125}, {"start": 1430.73, "end": 1431.15, "word": " Anyway,", "probability": 0.87109375}, {"start": 1432.43, "end": 1436.27, "word": " we", "probability": 0.94140625}, {"start": 1436.27, "end": 1436.67, "word": " have", "probability": 0.9443359375}], "temperature": 1.0}, {"id": 52, "seek": 146373, "start": 1437.85, "end": 1463.73, "text": " The English, uh, as in book, book. It is central back of the tongue, pronounced where the central back of the tongue is in half closed position and the lips are slightly rounded. Okay. Now we have the Arabic dhamma, uh. Okay.", "tokens": [440, 3669, 11, 2232, 11, 382, 294, 1446, 11, 1446, 13, 467, 307, 5777, 646, 295, 264, 10601, 11, 23155, 689, 264, 5777, 646, 295, 264, 10601, 307, 294, 1922, 5395, 2535, 293, 264, 10118, 366, 4748, 23382, 13, 1033, 13, 823, 321, 362, 264, 19938, 274, 4822, 1696, 11, 2232, 13, 1033, 13], "avg_logprob": -0.2811079502105713, "compression_ratio": 1.4675324675324675, "no_speech_prob": 0.0, "words": [{"start": 1437.85, "end": 1438.09, "word": " The", "probability": 0.78369140625}, {"start": 1438.09, "end": 1438.59, "word": " English,", "probability": 0.97607421875}, {"start": 1439.27, "end": 1439.47, "word": " uh,", "probability": 0.13330078125}, {"start": 1439.71, "end": 1440.15, "word": " as", "probability": 0.97216796875}, {"start": 1440.15, "end": 1440.73, "word": " in", "probability": 0.95166015625}, {"start": 1440.73, "end": 1441.29, "word": " book,", "probability": 0.51220703125}, {"start": 1441.91, "end": 1442.79, "word": " book.", "probability": 0.9521484375}, {"start": 1445.91, "end": 1446.61, "word": " It", "probability": 0.958984375}, {"start": 1446.61, "end": 1446.97, "word": " is", "probability": 0.919921875}, {"start": 1446.97, "end": 1448.35, "word": " central", "probability": 0.8525390625}, {"start": 1448.35, "end": 1448.73, "word": " back", "probability": 0.86083984375}, {"start": 1448.73, "end": 1448.87, "word": " of", "probability": 0.88525390625}, {"start": 1448.87, "end": 1448.99, "word": " the", "probability": 0.81396484375}, {"start": 1448.99, "end": 1449.09, "word": " tongue,", "probability": 0.361083984375}, {"start": 1449.13, "end": 1450.63, "word": " pronounced", "probability": 0.48388671875}, {"start": 1450.63, "end": 1451.03, "word": " where", "probability": 0.84375}, {"start": 1451.03, "end": 1451.19, "word": " the", "probability": 0.8916015625}, {"start": 1451.19, "end": 1451.49, "word": " central", "probability": 0.92431640625}, {"start": 1451.49, "end": 1451.81, "word": " back", "probability": 0.87060546875}, {"start": 1451.81, "end": 1451.95, "word": " of", "probability": 0.97119140625}, {"start": 1451.95, "end": 1452.07, "word": " the", "probability": 0.9248046875}, {"start": 1452.07, "end": 1452.39, "word": " tongue", "probability": 0.90185546875}, {"start": 1452.39, "end": 1453.33, "word": " is", "probability": 0.9326171875}, {"start": 1453.33, "end": 1453.65, "word": " in", "probability": 0.94970703125}, {"start": 1453.65, "end": 1453.95, "word": " half", "probability": 0.82177734375}, {"start": 1453.95, "end": 1454.29, "word": " closed", "probability": 0.64892578125}, {"start": 1454.29, "end": 1454.79, "word": " position", "probability": 0.93994140625}, {"start": 1454.79, "end": 1455.87, "word": " and", "probability": 0.53515625}, {"start": 1455.87, "end": 1456.01, "word": " the", "probability": 0.9013671875}, {"start": 1456.01, "end": 1456.23, "word": " lips", "probability": 0.89501953125}, {"start": 1456.23, "end": 1456.45, "word": " are", "probability": 0.93701171875}, {"start": 1456.45, "end": 1456.89, "word": " slightly", "probability": 0.85546875}, {"start": 1456.89, "end": 1457.31, "word": " rounded.", "probability": 0.888671875}, {"start": 1458.31, "end": 1458.47, "word": " Okay.", "probability": 0.81396484375}, {"start": 1459.15, "end": 1459.85, "word": " Now", "probability": 0.966796875}, {"start": 1459.85, "end": 1459.99, "word": " we", "probability": 0.93212890625}, {"start": 1459.99, "end": 1460.21, "word": " have", "probability": 0.94580078125}, {"start": 1460.21, "end": 1460.39, "word": " the", "probability": 0.92578125}, {"start": 1460.39, "end": 1460.71, "word": " Arabic", "probability": 0.919921875}, {"start": 1460.71, "end": 1461.19, "word": " dhamma,", "probability": 0.518310546875}, {"start": 1462.29, "end": 1462.47, "word": " uh.", "probability": 0.69775390625}, {"start": 1463.15, "end": 1463.73, "word": " Okay.", "probability": 0.88916015625}], "temperature": 1.0}, {"id": 53, "seek": 149083, "start": 1464.75, "end": 1490.83, "text": " which is produced by the tongue in the half-closed position with the round lips Dhamma means nominative case So we have the O sound available in both English and Arabic here", "tokens": [597, 307, 7126, 538, 264, 10601, 294, 264, 1922, 12, 3474, 1744, 2535, 365, 264, 3098, 10118, 413, 4822, 1696, 1355, 5369, 259, 1166, 1389, 407, 321, 362, 264, 422, 1626, 2435, 294, 1293, 3669, 293, 19938, 510], "avg_logprob": -0.25600962608288497, "compression_ratio": 1.3282442748091603, "no_speech_prob": 0.0, "words": [{"start": 1464.75, "end": 1465.01, "word": " which", "probability": 0.4521484375}, {"start": 1465.01, "end": 1465.17, "word": " is", "probability": 0.95263671875}, {"start": 1465.17, "end": 1465.73, "word": " produced", "probability": 0.8984375}, {"start": 1465.73, "end": 1466.27, "word": " by", "probability": 0.974609375}, {"start": 1466.27, "end": 1466.47, "word": " the", "probability": 0.92578125}, {"start": 1466.47, "end": 1466.89, "word": " tongue", "probability": 0.916015625}, {"start": 1466.89, "end": 1467.19, "word": " in", "probability": 0.94091796875}, {"start": 1467.19, "end": 1467.33, "word": " the", "probability": 0.9130859375}, {"start": 1467.33, "end": 1467.59, "word": " half", "probability": 0.90185546875}, {"start": 1467.59, "end": 1467.89, "word": "-closed", "probability": 0.7913411458333334}, {"start": 1467.89, "end": 1468.47, "word": " position", "probability": 0.94189453125}, {"start": 1468.47, "end": 1469.17, "word": " with", "probability": 0.8671875}, {"start": 1469.17, "end": 1469.31, "word": " the", "probability": 0.54736328125}, {"start": 1469.31, "end": 1469.61, "word": " round", "probability": 0.8916015625}, {"start": 1469.61, "end": 1470.11, "word": " lips", "probability": 0.8037109375}, {"start": 1470.11, "end": 1471.75, "word": " Dhamma", "probability": 0.6029459635416666}, {"start": 1471.75, "end": 1472.17, "word": " means", "probability": 0.92724609375}, {"start": 1472.17, "end": 1472.75, "word": " nominative", "probability": 0.7898763020833334}, {"start": 1472.75, "end": 1473.75, "word": " case", "probability": 0.92236328125}, {"start": 1473.75, "end": 1477.83, "word": " So", "probability": 0.1685791015625}, {"start": 1477.83, "end": 1484.01, "word": " we", "probability": 0.79150390625}, {"start": 1484.01, "end": 1484.37, "word": " have", "probability": 0.95263671875}, {"start": 1484.37, "end": 1486.51, "word": " the", "probability": 0.896484375}, {"start": 1486.51, "end": 1486.69, "word": " O", "probability": 0.62841796875}, {"start": 1486.69, "end": 1487.13, "word": " sound", "probability": 0.92529296875}, {"start": 1487.13, "end": 1488.25, "word": " available", "probability": 0.82275390625}, {"start": 1488.25, "end": 1488.67, "word": " in", "probability": 0.95068359375}, {"start": 1488.67, "end": 1488.95, "word": " both", "probability": 0.88330078125}, {"start": 1488.95, "end": 1489.43, "word": " English", "probability": 0.978515625}, {"start": 1489.43, "end": 1490.09, "word": " and", "probability": 0.94970703125}, {"start": 1490.09, "end": 1490.41, "word": " Arabic", "probability": 0.93310546875}, {"start": 1490.41, "end": 1490.83, "word": " here", "probability": 0.85400390625}], "temperature": 1.0}, {"id": 54, "seek": 152119, "start": 1491.75, "end": 1521.19, "text": " But its position is different. Now it is available as case assignment in Arabic. However, in English, it is part of pronunciation. So this is an area of difficulty as well. We have the Arabic accusative case, Fatha, which is represented as short vowel.", "tokens": [583, 1080, 2535, 307, 819, 13, 823, 309, 307, 2435, 382, 1389, 15187, 294, 19938, 13, 2908, 11, 294, 3669, 11, 309, 307, 644, 295, 23338, 13, 407, 341, 307, 364, 1859, 295, 10360, 382, 731, 13, 492, 362, 264, 19938, 11168, 1166, 1389, 11, 479, 29441, 11, 597, 307, 10379, 382, 2099, 29410, 13], "avg_logprob": -0.18931361846625805, "compression_ratio": 1.4375, "no_speech_prob": 0.0, "words": [{"start": 1491.75, "end": 1492.25, "word": " But", "probability": 0.515625}, {"start": 1492.25, "end": 1492.89, "word": " its", "probability": 0.72265625}, {"start": 1492.89, "end": 1493.47, "word": " position", "probability": 0.94970703125}, {"start": 1493.47, "end": 1494.01, "word": " is", "probability": 0.955078125}, {"start": 1494.01, "end": 1494.39, "word": " different.", "probability": 0.896484375}, {"start": 1494.53, "end": 1494.65, "word": " Now", "probability": 0.919921875}, {"start": 1494.65, "end": 1494.79, "word": " it", "probability": 0.64013671875}, {"start": 1494.79, "end": 1494.91, "word": " is", "probability": 0.93408203125}, {"start": 1494.91, "end": 1495.39, "word": " available", "probability": 0.8330078125}, {"start": 1495.39, "end": 1496.95, "word": " as", "probability": 0.955078125}, {"start": 1496.95, "end": 1497.53, "word": " case", "probability": 0.798828125}, {"start": 1497.53, "end": 1498.11, "word": " assignment", "probability": 0.9609375}, {"start": 1498.11, "end": 1498.43, "word": " in", "probability": 0.95556640625}, {"start": 1498.43, "end": 1498.83, "word": " Arabic.", "probability": 0.900390625}, {"start": 1501.19, "end": 1501.95, "word": " However,", "probability": 0.642578125}, {"start": 1502.15, "end": 1502.27, "word": " in", "probability": 0.9501953125}, {"start": 1502.27, "end": 1502.63, "word": " English,", "probability": 0.9775390625}, {"start": 1503.41, "end": 1503.53, "word": " it", "probability": 0.96044921875}, {"start": 1503.53, "end": 1503.67, "word": " is", "probability": 0.9443359375}, {"start": 1503.67, "end": 1504.07, "word": " part", "probability": 0.89501953125}, {"start": 1504.07, "end": 1504.39, "word": " of", "probability": 0.9736328125}, {"start": 1504.39, "end": 1504.93, "word": " pronunciation.", "probability": 0.95068359375}, {"start": 1506.73, "end": 1507.03, "word": " So", "probability": 0.94189453125}, {"start": 1507.03, "end": 1507.21, "word": " this", "probability": 0.73046875}, {"start": 1507.21, "end": 1507.35, "word": " is", "probability": 0.94775390625}, {"start": 1507.35, "end": 1507.59, "word": " an", "probability": 0.9599609375}, {"start": 1507.59, "end": 1507.87, "word": " area", "probability": 0.89501953125}, {"start": 1507.87, "end": 1508.11, "word": " of", "probability": 0.96728515625}, {"start": 1508.11, "end": 1508.61, "word": " difficulty", "probability": 0.72021484375}, {"start": 1508.61, "end": 1508.89, "word": " as", "probability": 0.92529296875}, {"start": 1508.89, "end": 1509.07, "word": " well.", "probability": 0.94482421875}, {"start": 1510.37, "end": 1510.69, "word": " We", "probability": 0.962890625}, {"start": 1510.69, "end": 1510.89, "word": " have", "probability": 0.94873046875}, {"start": 1510.89, "end": 1511.07, "word": " the", "probability": 0.91943359375}, {"start": 1511.07, "end": 1511.53, "word": " Arabic", "probability": 0.8896484375}, {"start": 1511.53, "end": 1513.73, "word": " accusative", "probability": 0.86279296875}, {"start": 1513.73, "end": 1514.25, "word": " case,", "probability": 0.9345703125}, {"start": 1514.95, "end": 1515.27, "word": " Fatha,", "probability": 0.3126220703125}, {"start": 1518.01, "end": 1518.61, "word": " which", "probability": 0.95068359375}, {"start": 1518.61, "end": 1518.73, "word": " is", "probability": 0.9501953125}, {"start": 1518.73, "end": 1519.15, "word": " represented", "probability": 0.79443359375}, {"start": 1519.15, "end": 1519.77, "word": " as", "probability": 0.91357421875}, {"start": 1519.77, "end": 1520.85, "word": " short", "probability": 0.71728515625}, {"start": 1520.85, "end": 1521.19, "word": " vowel.", "probability": 0.9501953125}], "temperature": 1.0}, {"id": 55, "seek": 154701, "start": 1524.27, "end": 1547.01, "text": " The tongue here is half open position and neutral lips. Okay. So I say الولدة الكتابة. Okay. We have", "tokens": [440, 10601, 510, 307, 1922, 1269, 2535, 293, 10598, 10118, 13, 1033, 13, 407, 286, 584, 2423, 12610, 3215, 3660, 33251, 2655, 16758, 3660, 13, 1033, 13, 492, 362], "avg_logprob": -0.2574218859275182, "compression_ratio": 1.0178571428571428, "no_speech_prob": 0.0, "words": [{"start": 1524.27, "end": 1524.51, "word": " The", "probability": 0.79150390625}, {"start": 1524.51, "end": 1524.85, "word": " tongue", "probability": 0.92822265625}, {"start": 1524.85, "end": 1525.15, "word": " here", "probability": 0.84033203125}, {"start": 1525.15, "end": 1525.37, "word": " is", "probability": 0.9375}, {"start": 1525.37, "end": 1525.67, "word": " half", "probability": 0.83740234375}, {"start": 1525.67, "end": 1526.07, "word": " open", "probability": 0.77294921875}, {"start": 1526.07, "end": 1526.67, "word": " position", "probability": 0.9345703125}, {"start": 1526.67, "end": 1527.29, "word": " and", "probability": 0.78173828125}, {"start": 1527.29, "end": 1527.71, "word": " neutral", "probability": 0.71240234375}, {"start": 1527.71, "end": 1528.15, "word": " lips.", "probability": 0.94287109375}, {"start": 1529.49, "end": 1529.65, "word": " Okay.", "probability": 0.6044921875}, {"start": 1530.47, "end": 1530.67, "word": " So", "probability": 0.9560546875}, {"start": 1530.67, "end": 1530.83, "word": " I", "probability": 0.8603515625}, {"start": 1530.83, "end": 1531.07, "word": " say", "probability": 0.8681640625}, {"start": 1531.07, "end": 1532.17, "word": " الولدة", "probability": 0.6893310546875}, {"start": 1532.17, "end": 1537.53, "word": " الكتابة.", "probability": 0.884521484375}, {"start": 1538.35, "end": 1539.17, "word": " Okay.", "probability": 0.79296875}, {"start": 1545.79, "end": 1546.61, "word": " We", "probability": 0.9375}, {"start": 1546.61, "end": 1547.01, "word": " have", "probability": 0.95703125}], "temperature": 1.0}, {"id": 56, "seek": 157816, "start": 1549.92, "end": 1578.16, "text": " The Ih sound, Ih, Ih sound as in set, pan, sex, egg, left. This is similar to the first sound Ih as in set. So your students confuse between these two short vowels. And the most problematic sound", "tokens": [440, 10485, 1626, 11, 10485, 11, 10485, 1626, 382, 294, 992, 11, 2462, 11, 3260, 11, 3777, 11, 1411, 13, 639, 307, 2531, 281, 264, 700, 1626, 10485, 382, 294, 992, 13, 407, 428, 1731, 28584, 1296, 613, 732, 2099, 44972, 13, 400, 264, 881, 19011, 1626], "avg_logprob": -0.25553385106225807, "compression_ratio": 1.4202898550724639, "no_speech_prob": 0.0, "words": [{"start": 1549.92, "end": 1550.44, "word": " The", "probability": 0.50341796875}, {"start": 1550.44, "end": 1551.58, "word": " Ih", "probability": 0.1304931640625}, {"start": 1551.58, "end": 1552.0, "word": " sound,", "probability": 0.81591796875}, {"start": 1552.22, "end": 1552.48, "word": " Ih,", "probability": 0.87939453125}, {"start": 1552.72, "end": 1552.86, "word": " Ih", "probability": 0.94677734375}, {"start": 1552.86, "end": 1553.52, "word": " sound", "probability": 0.7666015625}, {"start": 1553.52, "end": 1553.86, "word": " as", "probability": 0.63427734375}, {"start": 1553.86, "end": 1554.32, "word": " in", "probability": 0.9521484375}, {"start": 1554.32, "end": 1554.94, "word": " set,", "probability": 0.42724609375}, {"start": 1557.0, "end": 1557.46, "word": " pan,", "probability": 0.53662109375}, {"start": 1560.02, "end": 1560.48, "word": " sex,", "probability": 0.49267578125}, {"start": 1561.74, "end": 1562.18, "word": " egg,", "probability": 0.9140625}, {"start": 1563.2, "end": 1563.6, "word": " left.", "probability": 0.66552734375}, {"start": 1565.64, "end": 1566.56, "word": " This", "probability": 0.90625}, {"start": 1566.56, "end": 1567.14, "word": " is", "probability": 0.9541015625}, {"start": 1567.14, "end": 1567.46, "word": " similar", "probability": 0.9560546875}, {"start": 1567.46, "end": 1567.74, "word": " to", "probability": 0.9697265625}, {"start": 1567.74, "end": 1567.9, "word": " the", "probability": 0.92138671875}, {"start": 1567.9, "end": 1568.18, "word": " first", "probability": 0.88671875}, {"start": 1568.18, "end": 1568.66, "word": " sound", "probability": 0.873046875}, {"start": 1568.66, "end": 1569.14, "word": " Ih", "probability": 0.459716796875}, {"start": 1569.14, "end": 1569.6, "word": " as", "probability": 0.71337890625}, {"start": 1569.6, "end": 1569.78, "word": " in", "probability": 0.9482421875}, {"start": 1569.78, "end": 1570.06, "word": " set.", "probability": 0.90283203125}, {"start": 1571.24, "end": 1571.72, "word": " So", "probability": 0.923828125}, {"start": 1571.72, "end": 1572.16, "word": " your", "probability": 0.64404296875}, {"start": 1572.16, "end": 1572.64, "word": " students", "probability": 0.955078125}, {"start": 1572.64, "end": 1573.32, "word": " confuse", "probability": 0.5126953125}, {"start": 1573.32, "end": 1573.76, "word": " between", "probability": 0.87890625}, {"start": 1573.76, "end": 1574.12, "word": " these", "probability": 0.86376953125}, {"start": 1574.12, "end": 1574.46, "word": " two", "probability": 0.90380859375}, {"start": 1574.46, "end": 1575.26, "word": " short", "probability": 0.951171875}, {"start": 1575.26, "end": 1575.64, "word": " vowels.", "probability": 0.986328125}, {"start": 1576.44, "end": 1576.78, "word": " And", "probability": 0.9404296875}, {"start": 1576.78, "end": 1576.94, "word": " the", "probability": 0.916015625}, {"start": 1576.94, "end": 1577.14, "word": " most", "probability": 0.9140625}, {"start": 1577.14, "end": 1577.6, "word": " problematic", "probability": 0.85595703125}, {"start": 1577.6, "end": 1578.16, "word": " sound", "probability": 0.89794921875}], "temperature": 1.0}, {"id": 57, "seek": 160270, "start": 1579.28, "end": 1602.7, "text": " is the schwa because this represents the weak forms of English. We have weak forms in English that differ or that are not available in Arabic. So in Arabic we have strong", "tokens": [307, 264, 956, 4151, 570, 341, 8855, 264, 5336, 6422, 295, 3669, 13, 492, 362, 5336, 6422, 294, 3669, 300, 743, 420, 300, 366, 406, 2435, 294, 19938, 13, 407, 294, 19938, 321, 362, 2068], "avg_logprob": -0.2502170039547814, "compression_ratio": 1.4491525423728813, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 1579.28, "end": 1579.58, "word": " is", "probability": 0.35888671875}, {"start": 1579.58, "end": 1579.72, "word": " the", "probability": 0.7783203125}, {"start": 1579.72, "end": 1580.0, "word": " schwa", "probability": 0.545074462890625}, {"start": 1580.0, "end": 1581.1, "word": " because", "probability": 0.4130859375}, {"start": 1581.1, "end": 1581.42, "word": " this", "probability": 0.93212890625}, {"start": 1581.42, "end": 1582.02, "word": " represents", "probability": 0.92333984375}, {"start": 1582.02, "end": 1582.22, "word": " the", "probability": 0.8896484375}, {"start": 1582.22, "end": 1582.5, "word": " weak", "probability": 0.974609375}, {"start": 1582.5, "end": 1583.0, "word": " forms", "probability": 0.92138671875}, {"start": 1583.0, "end": 1583.94, "word": " of", "probability": 0.96484375}, {"start": 1583.94, "end": 1584.36, "word": " English.", "probability": 0.97705078125}, {"start": 1584.76, "end": 1585.1, "word": " We", "probability": 0.9609375}, {"start": 1585.1, "end": 1585.32, "word": " have", "probability": 0.95166015625}, {"start": 1585.32, "end": 1585.58, "word": " weak", "probability": 0.9775390625}, {"start": 1585.58, "end": 1586.0, "word": " forms", "probability": 0.91357421875}, {"start": 1586.0, "end": 1587.82, "word": " in", "probability": 0.943359375}, {"start": 1587.82, "end": 1588.2, "word": " English", "probability": 0.9755859375}, {"start": 1588.2, "end": 1589.26, "word": " that", "probability": 0.9248046875}, {"start": 1589.26, "end": 1590.22, "word": " differ", "probability": 0.95947265625}, {"start": 1590.22, "end": 1591.6, "word": " or", "probability": 0.79345703125}, {"start": 1591.6, "end": 1591.82, "word": " that", "probability": 0.890625}, {"start": 1591.82, "end": 1592.04, "word": " are", "probability": 0.372314453125}, {"start": 1592.04, "end": 1592.32, "word": " not", "probability": 0.94580078125}, {"start": 1592.32, "end": 1592.84, "word": " available", "probability": 0.81494140625}, {"start": 1592.84, "end": 1594.32, "word": " in", "probability": 0.94873046875}, {"start": 1594.32, "end": 1594.64, "word": " Arabic.", "probability": 0.92626953125}, {"start": 1595.82, "end": 1596.26, "word": " So", "probability": 0.86083984375}, {"start": 1596.26, "end": 1598.02, "word": " in", "probability": 0.53759765625}, {"start": 1598.02, "end": 1598.28, "word": " Arabic", "probability": 0.91455078125}, {"start": 1598.28, "end": 1598.6, "word": " we", "probability": 0.52783203125}, {"start": 1598.6, "end": 1599.04, "word": " have", "probability": 0.947265625}, {"start": 1599.04, "end": 1602.7, "word": " strong", "probability": 0.83984375}], "temperature": 1.0}, {"id": 58, "seek": 163337, "start": 1604.09, "end": 1633.37, "text": " pronunciation or strong pitch that is available in nearly every single word of Arabic. However, in English, we have weak forms and strong forms. I mean, high pitch and low pitch. So, you have some words are pronounced with weak forms with what is called chwa. Okay? These are the pronouns of English.", "tokens": [23338, 420, 2068, 7293, 300, 307, 2435, 294, 6217, 633, 2167, 1349, 295, 19938, 13, 2908, 11, 294, 3669, 11, 321, 362, 5336, 6422, 293, 2068, 6422, 13, 286, 914, 11, 1090, 7293, 293, 2295, 7293, 13, 407, 11, 291, 362, 512, 2283, 366, 23155, 365, 5336, 6422, 365, 437, 307, 1219, 417, 4151, 13, 1033, 30, 1981, 366, 264, 35883, 295, 3669, 13], "avg_logprob": -0.2092548076923077, "compression_ratio": 1.5759162303664922, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1604.09, "end": 1604.65, "word": " pronunciation", "probability": 0.7607421875}, {"start": 1604.65, "end": 1605.23, "word": " or", "probability": 0.8056640625}, {"start": 1605.23, "end": 1605.67, "word": " strong", "probability": 0.88818359375}, {"start": 1605.67, "end": 1606.25, "word": " pitch", "probability": 0.90478515625}, {"start": 1606.25, "end": 1607.03, "word": " that", "probability": 0.80908203125}, {"start": 1607.03, "end": 1607.21, "word": " is", 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"probability": 0.9658203125}, {"start": 1614.33, "end": 1614.61, "word": " have", "probability": 0.9482421875}, {"start": 1614.61, "end": 1615.05, "word": " weak", "probability": 0.96630859375}, {"start": 1615.05, "end": 1615.53, "word": " forms", "probability": 0.9306640625}, {"start": 1615.53, "end": 1616.57, "word": " and", "probability": 0.9345703125}, {"start": 1616.57, "end": 1617.07, "word": " strong", "probability": 0.9013671875}, {"start": 1617.07, "end": 1617.63, "word": " forms.", "probability": 0.88232421875}, {"start": 1618.23, "end": 1618.59, "word": " I", "probability": 0.9921875}, {"start": 1618.59, "end": 1618.73, "word": " mean,", "probability": 0.966796875}, {"start": 1618.81, "end": 1619.07, "word": " high", "probability": 0.9052734375}, {"start": 1619.07, "end": 1619.47, "word": " pitch", "probability": 0.76171875}, {"start": 1619.47, "end": 1620.57, "word": " and", "probability": 0.9169921875}, {"start": 1620.57, "end": 1620.95, "word": " low", "probability": 0.94287109375}, {"start": 1620.95, "end": 1621.37, "word": " pitch.", "probability": 0.9306640625}, {"start": 1622.37, "end": 1622.69, "word": " So,", "probability": 0.90966796875}, {"start": 1622.77, "end": 1622.85, "word": " you", "probability": 0.919921875}, {"start": 1622.85, "end": 1623.07, "word": " have", "probability": 0.9189453125}, {"start": 1623.07, "end": 1623.35, "word": " some", "probability": 0.89501953125}, {"start": 1623.35, "end": 1623.79, "word": " words", "probability": 0.87060546875}, {"start": 1623.79, "end": 1624.87, "word": " are", "probability": 0.5517578125}, {"start": 1624.87, "end": 1625.35, "word": " pronounced", "probability": 0.80126953125}, {"start": 1625.35, "end": 1625.71, "word": " with", "probability": 0.9052734375}, {"start": 1625.71, "end": 1626.03, "word": " weak", "probability": 0.96875}, {"start": 1626.03, "end": 1626.47, "word": " forms", "probability": 0.91796875}, {"start": 1626.47, "end": 1627.43, "word": " with", "probability": 0.71484375}, {"start": 1627.43, "end": 1627.63, "word": " what", "probability": 0.93408203125}, {"start": 1627.63, "end": 1627.79, "word": " is", "probability": 0.490234375}, {"start": 1627.79, "end": 1628.17, "word": " called", "probability": 0.900390625}, {"start": 1628.17, "end": 1628.57, "word": " chwa.", "probability": 0.3560791015625}, {"start": 1629.25, "end": 1629.51, "word": " Okay?", "probability": 0.634765625}, {"start": 1630.05, "end": 1630.61, "word": " These", "probability": 0.931640625}, {"start": 1630.61, "end": 1631.05, "word": " are", "probability": 0.939453125}, {"start": 1631.05, "end": 1631.91, "word": " the", "probability": 0.927734375}, {"start": 1631.91, "end": 1632.43, "word": " pronouns", "probability": 0.86376953125}, {"start": 1632.43, "end": 1632.99, "word": " of", "probability": 0.96875}, {"start": 1632.99, "end": 1633.37, "word": " English.", "probability": 0.97705078125}], "temperature": 1.0}, {"id": 59, "seek": 165977, "start": 1634.41, "end": 1659.77, "text": " The prepositions of English. The determination system of English. Articles, a, n, the. We have the one word syllable in connected speech. We have the conjunctions as well. These are weak forms.", "tokens": [440, 2666, 329, 2451, 295, 3669, 13, 440, 18432, 1185, 295, 3669, 13, 5735, 5350, 11, 257, 11, 297, 11, 264, 13, 492, 362, 264, 472, 1349, 40151, 294, 4582, 6218, 13, 492, 362, 264, 18244, 3916, 382, 731, 13, 1981, 366, 5336, 6422, 13], "avg_logprob": -0.1939537991648135, "compression_ratio": 1.4477611940298507, "no_speech_prob": 0.0, "words": [{"start": 1634.41, "end": 1634.63, "word": " The", "probability": 0.340576171875}, {"start": 1634.63, "end": 1635.33, "word": " prepositions", "probability": 0.9296875}, {"start": 1635.33, "end": 1636.07, "word": " of", "probability": 0.9736328125}, {"start": 1636.07, "end": 1636.49, "word": " English.", "probability": 0.98046875}, {"start": 1637.59, "end": 1638.13, "word": " The", "probability": 0.89501953125}, {"start": 1638.13, "end": 1638.63, "word": " determination", "probability": 0.958984375}, {"start": 1638.63, "end": 1639.33, "word": " system", "probability": 0.94873046875}, {"start": 1639.33, "end": 1639.51, "word": " of", "probability": 0.97314453125}, {"start": 1639.51, "end": 1639.91, "word": " English.", "probability": 0.97998046875}, {"start": 1640.81, "end": 1641.77, "word": " Articles,", "probability": 0.853759765625}, {"start": 1642.07, "end": 1642.39, "word": " a,", "probability": 0.6083984375}, {"start": 1642.53, "end": 1643.07, "word": " n,", "probability": 0.5966796875}, {"start": 1643.45, "end": 1643.65, "word": " the.", "probability": 0.83837890625}, {"start": 1644.85, "end": 1645.79, "word": " We", "probability": 0.8056640625}, {"start": 1645.79, "end": 1646.25, "word": " have", "probability": 0.95361328125}, {"start": 1646.25, "end": 1647.07, "word": " the", "probability": 0.81494140625}, {"start": 1647.07, "end": 1647.55, "word": " one", "probability": 0.9375}, {"start": 1647.55, "end": 1649.03, "word": " word", "probability": 0.58837890625}, {"start": 1649.03, "end": 1649.87, "word": " syllable", "probability": 0.79638671875}, {"start": 1649.87, "end": 1651.69, "word": " in", "probability": 0.419921875}, {"start": 1651.69, "end": 1652.07, "word": " connected", "probability": 0.89453125}, {"start": 1652.07, "end": 1652.63, "word": " speech.", "probability": 0.96142578125}, {"start": 1654.55, "end": 1655.51, "word": " We", "probability": 0.91796875}, {"start": 1655.51, "end": 1655.85, "word": " have", "probability": 0.947265625}, {"start": 1655.85, "end": 1656.21, "word": " the", "probability": 0.66650390625}, {"start": 1656.21, "end": 1656.89, "word": " conjunctions", "probability": 0.94140625}, {"start": 1656.89, "end": 1657.09, "word": " as", "probability": 0.9267578125}, {"start": 1657.09, "end": 1657.31, "word": " well.", "probability": 0.94482421875}, {"start": 1658.29, "end": 1658.69, "word": " These", "probability": 0.9287109375}, {"start": 1658.69, "end": 1659.05, "word": " are", "probability": 0.93994140625}, {"start": 1659.05, "end": 1659.35, "word": " weak", "probability": 0.98046875}, {"start": 1659.35, "end": 1659.77, "word": " forms.", "probability": 0.93994140625}], "temperature": 1.0}, {"id": 60, "seek": 168776, "start": 1661.8, "end": 1687.76, "text": " The suffixation at the end of a word is weak form. I say, for example, father, mother, farmer. The final part is always weak. The final part of a word is always weak. This is in isolation. But the situation differs if these words are pronounced in connected utterance.", "tokens": [440, 3889, 970, 399, 412, 264, 917, 295, 257, 1349, 307, 5336, 1254, 13, 286, 584, 11, 337, 1365, 11, 3086, 11, 2895, 11, 17891, 13, 440, 2572, 644, 307, 1009, 5336, 13, 440, 2572, 644, 295, 257, 1349, 307, 1009, 5336, 13, 639, 307, 294, 16001, 13, 583, 264, 2590, 37761, 498, 613, 2283, 366, 23155, 294, 4582, 17567, 719, 13], "avg_logprob": -0.12574405234957498, "compression_ratio": 1.68125, "no_speech_prob": 0.0, "words": [{"start": 1661.8, "end": 1662.48, "word": " The", "probability": 0.52099609375}, {"start": 1662.48, "end": 1663.16, "word": " suffixation", "probability": 0.9720052083333334}, {"start": 1663.16, "end": 1663.36, "word": " at", "probability": 0.9443359375}, {"start": 1663.36, "end": 1663.48, "word": " the", "probability": 0.92578125}, {"start": 1663.48, "end": 1663.64, "word": " end", "probability": 0.90576171875}, {"start": 1663.64, "end": 1663.78, "word": " of", "probability": 0.97265625}, {"start": 1663.78, "end": 1663.94, "word": " a", "probability": 0.93408203125}, {"start": 1663.94, "end": 1664.22, "word": " word", "probability": 0.93994140625}, {"start": 1664.22, "end": 1664.6, "word": " is", "probability": 0.935546875}, {"start": 1664.6, "end": 1664.84, "word": " weak", "probability": 0.89404296875}, {"start": 1664.84, "end": 1665.14, "word": " form.", "probability": 0.87451171875}, {"start": 1666.9, "end": 1667.18, "word": " I", "probability": 0.69873046875}, {"start": 1667.18, "end": 1667.38, "word": " say,", "probability": 0.72998046875}, {"start": 1667.48, "end": 1667.54, "word": " for", "probability": 0.9521484375}, {"start": 1667.54, "end": 1667.94, "word": " example,", "probability": 0.96728515625}, {"start": 1668.42, "end": 1668.76, "word": " father,", "probability": 0.70361328125}, {"start": 1669.96, "end": 1670.46, "word": " mother,", "probability": 0.86572265625}, {"start": 1671.52, "end": 1671.84, "word": " farmer.", "probability": 0.9716796875}, {"start": 1672.42, "end": 1672.76, "word": " The", "probability": 0.8955078125}, {"start": 1672.76, "end": 1673.06, "word": " final", "probability": 0.94970703125}, {"start": 1673.06, "end": 1673.56, "word": " part", "probability": 0.880859375}, {"start": 1673.56, "end": 1674.32, "word": " is", "probability": 0.93603515625}, {"start": 1674.32, "end": 1674.92, "word": " always", "probability": 0.91064453125}, {"start": 1674.92, "end": 1675.92, "word": " weak.", "probability": 0.96630859375}, {"start": 1677.2, "end": 1677.8, "word": " The", "probability": 0.8408203125}, {"start": 1677.8, "end": 1678.12, "word": " final", "probability": 0.93359375}, {"start": 1678.12, "end": 1678.52, "word": " part", "probability": 0.8818359375}, {"start": 1678.52, "end": 1678.66, "word": " of", "probability": 0.96826171875}, {"start": 1678.66, "end": 1678.8, "word": " a", "probability": 0.943359375}, {"start": 1678.8, "end": 1679.1, "word": " word", "probability": 0.9375}, {"start": 1679.1, "end": 1679.8, "word": " is", "probability": 0.9453125}, {"start": 1679.8, "end": 1680.2, "word": " always", "probability": 0.91259765625}, {"start": 1680.2, "end": 1680.52, "word": " weak.", "probability": 0.97216796875}, {"start": 1680.58, "end": 1680.74, "word": " This", "probability": 0.8935546875}, {"start": 1680.74, "end": 1680.88, "word": " is", "probability": 0.94873046875}, {"start": 1680.88, "end": 1681.02, "word": " in", "probability": 0.57080078125}, {"start": 1681.02, "end": 1681.38, "word": " isolation.", "probability": 0.92431640625}, {"start": 1682.02, "end": 1682.2, "word": " But", "probability": 0.9306640625}, {"start": 1682.2, "end": 1682.3, "word": " the", "probability": 0.8681640625}, {"start": 1682.3, "end": 1682.7, "word": " situation", "probability": 0.93896484375}, {"start": 1682.7, "end": 1683.12, "word": " differs", "probability": 0.91357421875}, {"start": 1683.12, "end": 1683.46, "word": " if", "probability": 0.9326171875}, {"start": 1683.46, "end": 1683.82, "word": " these", "probability": 0.85986328125}, {"start": 1683.82, "end": 1684.24, "word": " words", "probability": 0.8427734375}, {"start": 1684.24, "end": 1684.7, "word": " are", "probability": 0.93359375}, {"start": 1684.7, "end": 1685.5, "word": " pronounced", "probability": 0.77734375}, {"start": 1685.5, "end": 1685.82, "word": " in", "probability": 0.93212890625}, {"start": 1685.82, "end": 1686.36, "word": " connected", "probability": 0.87255859375}, {"start": 1686.36, "end": 1687.76, "word": " utterance.", "probability": 0.83984375}], "temperature": 1.0}, {"id": 61, "seek": 171099, "start": 1688.71, "end": 1710.99, "text": "due to having the different subra segmental phonemes of English. But still, the schwach system marks the English language pronunciation. Okay? So it is not found in Arabic and accordingly it's highly problematic. Let's see.", "tokens": [67, 622, 281, 1419, 264, 819, 1422, 424, 9469, 304, 30754, 443, 279, 295, 3669, 13, 583, 920, 11, 264, 17932, 608, 1185, 10640, 264, 3669, 2856, 23338, 13, 1033, 30, 407, 309, 307, 406, 1352, 294, 19938, 293, 19717, 309, 311, 5405, 19011, 13, 961, 311, 536, 13], "avg_logprob": -0.23234375238418578, "compression_ratio": 1.3433734939759037, "no_speech_prob": 0.0, "words": [{"start": 1688.71, "end": 1689.03, "word": "due", "probability": 0.840576171875}, {"start": 1689.03, "end": 1689.19, "word": " to", "probability": 0.97314453125}, {"start": 1689.19, "end": 1689.61, "word": " having", "probability": 0.87353515625}, {"start": 1689.61, "end": 1690.39, "word": " the", "probability": 0.74658203125}, {"start": 1690.39, "end": 1691.09, "word": " different", "probability": 0.45263671875}, {"start": 1691.09, "end": 1691.41, "word": " subra", "probability": 0.4739990234375}, {"start": 1691.41, "end": 1691.99, "word": " segmental", "probability": 0.725830078125}, {"start": 1691.99, "end": 1692.43, "word": " phonemes", "probability": 0.95703125}, {"start": 1692.43, "end": 1692.57, "word": " of", "probability": 0.9228515625}, {"start": 1692.57, "end": 1692.97, "word": " English.", "probability": 0.978515625}, {"start": 1693.81, "end": 1694.07, "word": " But", "probability": 0.8984375}, {"start": 1694.07, "end": 1694.49, "word": " still,", "probability": 0.916015625}, {"start": 1695.11, "end": 1695.23, "word": " the", "probability": 0.9267578125}, {"start": 1695.23, "end": 1695.53, "word": " schwach", "probability": 0.53955078125}, {"start": 1695.53, "end": 1696.09, "word": " system", "probability": 0.958984375}, {"start": 1696.09, "end": 1697.85, "word": " marks", "probability": 0.88330078125}, {"start": 1697.85, "end": 1699.43, "word": " the", "probability": 0.8154296875}, {"start": 1699.43, "end": 1699.91, "word": " English", "probability": 0.9580078125}, {"start": 1699.91, "end": 1700.87, "word": " language", "probability": 0.830078125}, {"start": 1700.87, "end": 1702.25, "word": " pronunciation.", "probability": 0.8974609375}, {"start": 1703.09, "end": 1703.65, "word": " Okay?", "probability": 0.444580078125}, {"start": 1704.19, "end": 1704.59, "word": " So", "probability": 0.931640625}, {"start": 1704.59, "end": 1704.69, "word": " it", "probability": 0.60400390625}, {"start": 1704.69, "end": 1704.81, "word": " is", "probability": 0.9052734375}, {"start": 1704.81, "end": 1704.97, "word": " not", "probability": 0.94873046875}, {"start": 1704.97, "end": 1705.29, "word": " found", "probability": 0.91064453125}, {"start": 1705.29, "end": 1705.47, "word": " in", "probability": 0.94873046875}, {"start": 1705.47, "end": 1705.73, "word": " Arabic", "probability": 0.93017578125}, {"start": 1705.73, "end": 1706.71, "word": " and", "probability": 0.478759765625}, {"start": 1706.71, "end": 1707.43, "word": " accordingly", "probability": 0.689453125}, {"start": 1707.43, "end": 1708.33, "word": " it's", "probability": 0.7275390625}, {"start": 1708.33, "end": 1708.85, "word": " highly", "probability": 0.92529296875}, {"start": 1708.85, "end": 1709.49, "word": " problematic.", "probability": 0.83349609375}, {"start": 1710.43, "end": 1710.79, "word": " Let's", "probability": 0.973876953125}, {"start": 1710.79, "end": 1710.99, "word": " see.", "probability": 0.923828125}], "temperature": 1.0}, {"id": 62, "seek": 174639, "start": 1721.37, "end": 1746.39, "text": " We see, for example, banana. The final part of a word is schwa. You find the schwa in almost all words of English in isolation, which are suffixed by any suffix. However, you find the schwa", "tokens": [492, 536, 11, 337, 1365, 11, 14194, 13, 440, 2572, 644, 295, 257, 1349, 307, 956, 4151, 13, 509, 915, 264, 956, 4151, 294, 1920, 439, 2283, 295, 3669, 294, 16001, 11, 597, 366, 3889, 40303, 538, 604, 3889, 970, 13, 2908, 11, 291, 915, 264, 956, 4151], "avg_logprob": -0.15808354591836735, "compression_ratio": 1.3970588235294117, "no_speech_prob": 0.0, "words": [{"start": 1721.37, "end": 1721.59, "word": " We", "probability": 0.7353515625}, {"start": 1721.59, "end": 1721.75, "word": " see,", "probability": 0.90625}, {"start": 1721.87, "end": 1721.91, "word": " for", "probability": 0.951171875}, {"start": 1721.91, "end": 1722.35, "word": " example,", "probability": 0.97021484375}, {"start": 1723.69, "end": 1724.53, "word": " banana.", "probability": 0.52294921875}, {"start": 1726.79, "end": 1727.63, "word": " The", "probability": 0.88916015625}, {"start": 1727.63, "end": 1727.95, "word": " final", "probability": 0.94775390625}, {"start": 1727.95, "end": 1728.31, "word": " part", "probability": 0.88427734375}, {"start": 1728.31, "end": 1728.45, "word": " of", "probability": 0.9697265625}, {"start": 1728.45, "end": 1728.59, "word": " a", "probability": 0.6630859375}, {"start": 1728.59, "end": 1728.97, "word": " word", "probability": 0.93505859375}, {"start": 1728.97, "end": 1729.73, "word": " is", "probability": 0.955078125}, {"start": 1729.73, "end": 1730.01, "word": " schwa.", "probability": 0.74853515625}, {"start": 1732.07, "end": 1732.91, "word": " You", "probability": 0.43310546875}, {"start": 1732.91, "end": 1733.29, "word": " find", "probability": 0.6826171875}, {"start": 1733.29, "end": 1733.47, "word": " the", "probability": 0.8876953125}, {"start": 1733.47, "end": 1733.73, "word": " schwa", "probability": 0.941162109375}, {"start": 1733.73, "end": 1734.27, "word": " in", "probability": 0.943359375}, {"start": 1734.27, "end": 1735.27, "word": " almost", "probability": 0.8212890625}, {"start": 1735.27, "end": 1736.29, "word": " all", "probability": 0.9462890625}, {"start": 1736.29, "end": 1737.25, "word": " words", "probability": 0.849609375}, {"start": 1737.25, "end": 1737.47, "word": " of", "probability": 0.9150390625}, {"start": 1737.47, "end": 1737.89, "word": " English", "probability": 0.97998046875}, {"start": 1737.89, "end": 1738.73, "word": " in", "probability": 0.5205078125}, {"start": 1738.73, "end": 1739.27, "word": " isolation,", "probability": 0.9423828125}, {"start": 1739.93, "end": 1740.21, "word": " which", "probability": 0.94677734375}, {"start": 1740.21, "end": 1740.65, "word": " are", "probability": 0.94189453125}, {"start": 1740.65, "end": 1741.61, "word": " suffixed", "probability": 0.948974609375}, {"start": 1741.61, "end": 1742.67, "word": " by", "probability": 0.95849609375}, {"start": 1742.67, "end": 1743.03, "word": " any", "probability": 0.9140625}, {"start": 1743.03, "end": 1743.49, "word": " suffix.", "probability": 0.992431640625}, {"start": 1744.57, "end": 1745.41, "word": " However,", "probability": 0.8076171875}, {"start": 1745.55, "end": 1745.67, "word": " you", "probability": 0.96142578125}, {"start": 1745.67, "end": 1745.95, "word": " find", "probability": 0.83837890625}, {"start": 1745.95, "end": 1746.13, "word": " the", "probability": 0.9072265625}, {"start": 1746.13, "end": 1746.39, "word": " schwa", "probability": 0.95166015625}], "temperature": 1.0}, {"id": 63, "seek": 177322, "start": 1747.44, "end": 1773.22, "text": " in the sentence, on sentences of English which contain the weak forms which I mentioned. Today, I don't say, today, this is in isolation. It's not choix. But in connected speech, I say, for example, today I want to show you the anatomy of a horse. Today I want to show you the anatomy of a horse. 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Okay? This is not English. And I'm sure that the native speakers of English will never understand you if you say this, because you borrow the Arabic system into English. 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It is schwa. I want to show you. We don't have I in English except being stressed. Otherwise, we pronounce it ah. Today, I want to show you the anatomy of a horse. 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There's a big difference here in interpretation or translation between the two sentences. The stress is meaningful. The first sentence does not contain stress on the pronoun I. However, the second sentence has this stress marking the pronoun I. So this makes difference in meaning. Could you translate?", "tokens": [708, 311, 264, 2649, 30, 821, 311, 257, 955, 2649, 510, 294, 14174, 420, 12853, 1296, 264, 732, 16579, 13, 440, 4244, 307, 10995, 13, 440, 700, 8174, 775, 406, 5304, 4244, 322, 264, 14144, 286, 13, 2908, 11, 264, 1150, 8174, 575, 341, 4244, 25482, 264, 14144, 286, 13, 407, 341, 1669, 2649, 294, 3620, 13, 7497, 291, 13799, 30], "avg_logprob": -0.12878024602128613, "compression_ratio": 1.7433155080213905, "no_speech_prob": 0.0, "words": [{"start": 1829.0, "end": 1829.3, "word": " What's", "probability": 0.716552734375}, {"start": 1829.3, "end": 1829.44, "word": " the", "probability": 0.9267578125}, {"start": 1829.44, "end": 1829.84, "word": " difference?", "probability": 0.857421875}, {"start": 1830.84, "end": 1831.14, "word": " There's", "probability": 0.69384765625}, {"start": 1831.14, "end": 1831.24, "word": " a", "probability": 0.99658203125}, {"start": 1831.24, "end": 1831.44, "word": " big", "probability": 0.9140625}, {"start": 1831.44, "end": 1831.96, "word": " difference", "probability": 0.87109375}, {"start": 1831.96, "end": 1832.32, "word": " here", "probability": 0.83837890625}, {"start": 1832.32, "end": 1832.58, "word": " in", "probability": 0.86279296875}, {"start": 1832.58, "end": 1833.14, "word": " interpretation", "probability": 0.89208984375}, {"start": 1833.14, "end": 1833.72, "word": " or", "probability": 0.7529296875}, {"start": 1833.72, "end": 1834.22, "word": " translation", "probability": 0.8544921875}, {"start": 1834.22, "end": 1834.54, "word": " between", "probability": 0.88037109375}, {"start": 1834.54, "end": 1834.72, "word": " the", "probability": 0.9130859375}, {"start": 1834.72, "end": 1834.9, "word": " two", "probability": 0.93798828125}, {"start": 1834.9, "end": 1835.44, "word": " sentences.", "probability": 0.9541015625}, {"start": 1836.18, "end": 1836.32, "word": " The", "probability": 0.89404296875}, {"start": 1836.32, "end": 1836.68, "word": " stress", "probability": 0.87890625}, {"start": 1836.68, "end": 1837.88, "word": " is", "probability": 0.95068359375}, {"start": 1837.88, "end": 1838.28, "word": " meaningful.", "probability": 0.92919921875}, {"start": 1839.88, "end": 1840.36, "word": " The", "probability": 0.8955078125}, {"start": 1840.36, "end": 1840.58, "word": " first", "probability": 0.88232421875}, {"start": 1840.58, "end": 1841.0, "word": " sentence", "probability": 0.9462890625}, {"start": 1841.0, "end": 1841.3, "word": " does", "probability": 0.9609375}, {"start": 1841.3, "end": 1842.0, "word": " not", "probability": 0.90087890625}, {"start": 1842.0, "end": 1842.58, "word": " contain", "probability": 0.943359375}, {"start": 1842.58, "end": 1843.52, "word": " stress", "probability": 0.9287109375}, {"start": 1843.52, "end": 1844.02, "word": " on", "probability": 0.95263671875}, {"start": 1844.02, "end": 1844.22, "word": " the", "probability": 0.9248046875}, {"start": 1844.22, "end": 1844.5, "word": " pronoun", "probability": 0.9541015625}, {"start": 1844.5, "end": 1845.98, "word": " I.", "probability": 0.373046875}, {"start": 1846.66, "end": 1847.08, "word": " However,", "probability": 0.87744140625}, {"start": 1847.18, "end": 1847.32, "word": " the", "probability": 0.91552734375}, {"start": 1847.32, "end": 1847.56, "word": " second", "probability": 0.89990234375}, {"start": 1847.56, "end": 1848.16, "word": " sentence", "probability": 0.935546875}, {"start": 1848.16, "end": 1849.02, "word": " has", "probability": 0.9384765625}, {"start": 1849.02, "end": 1849.3, "word": " this", "probability": 0.7890625}, {"start": 1849.3, "end": 1849.74, "word": " stress", "probability": 0.93017578125}, {"start": 1849.74, "end": 1850.62, "word": " marking", "probability": 0.92041015625}, {"start": 1850.62, "end": 1851.36, "word": " the", "probability": 0.91796875}, {"start": 1851.36, "end": 1851.58, "word": " pronoun", "probability": 0.9560546875}, {"start": 1851.58, "end": 1852.1, "word": " I.", "probability": 0.95458984375}, {"start": 1852.18, "end": 1852.32, "word": " So", "probability": 0.92333984375}, {"start": 1852.32, "end": 1852.58, "word": " this", "probability": 0.56005859375}, {"start": 1852.58, "end": 1853.46, "word": " makes", "probability": 0.84716796875}, {"start": 1853.46, "end": 1854.0, "word": " difference", "probability": 0.68603515625}, {"start": 1854.0, "end": 1854.38, "word": " in", "probability": 0.947265625}, {"start": 1854.38, "end": 1854.68, "word": " meaning.", "probability": 0.861328125}, {"start": 1855.36, "end": 1855.56, "word": " Could", "probability": 0.87060546875}, {"start": 1855.56, "end": 1855.68, "word": " you", "probability": 0.96728515625}, {"start": 1855.68, "end": 1856.1, "word": " translate?", "probability": 0.81640625}], "temperature": 1.0}, {"id": 67, "seek": 188442, "start": 1857.7, "end": 1884.42, "text": " Today I want to show you the anatomy of a horse. Today I want to show you the anatomy of a horse. So what's the difference? The first one. اليوم سأوريكم تشريح الحصار. I am your teacher. You are familiar with me. I come every class. 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Not anyone else. Not any other professors. I myself am going to teach you such and such. Okay? So there is a big difference here. If you master the stressed system and the schwach system or the weak form, you can easily understand the native speakers of English. 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"end": 1958.75, "text": " you misunderstand them and accordingly produce wrong and very distant translation or interpretation. Is it clear? Okay. We have the A sound as in attack. Attack. Banana. Bad.", "tokens": [291, 35736, 552, 293, 19717, 5258, 2085, 293, 588, 17275, 12853, 420, 14174, 13, 1119, 309, 1850, 30, 1033, 13, 492, 362, 264, 316, 1626, 382, 294, 2690, 13, 22477, 13, 39588, 13, 11523, 13], "avg_logprob": -0.2858072850439284, "compression_ratio": 1.3461538461538463, "no_speech_prob": 0.0, "words": [{"start": 1931.61, "end": 1932.11, "word": " you", "probability": 0.377197265625}, {"start": 1932.11, "end": 1932.93, "word": " misunderstand", "probability": 0.92041015625}, {"start": 1932.93, "end": 1933.71, "word": " them", "probability": 0.9140625}, {"start": 1933.71, "end": 1934.17, "word": " and", "probability": 0.84130859375}, {"start": 1934.17, "end": 1934.99, "word": " accordingly", "probability": 0.9013671875}, {"start": 1934.99, "end": 1935.77, "word": " produce", "probability": 0.728515625}, {"start": 1935.77, "end": 1936.83, "word": " wrong", "probability": 0.8369140625}, {"start": 1936.83, "end": 1938.13, "word": " and", "probability": 0.84765625}, {"start": 1938.13, "end": 1938.43, "word": " very", "probability": 0.84765625}, {"start": 1938.43, "end": 1938.95, "word": " distant", "probability": 0.9453125}, {"start": 1938.95, "end": 1939.63, "word": " translation", "probability": 0.6845703125}, {"start": 1939.63, "end": 1940.01, "word": " or", "probability": 0.9404296875}, {"start": 1940.01, "end": 1940.59, "word": " interpretation.", "probability": 0.8857421875}, {"start": 1941.85, "end": 1942.11, "word": " Is", "probability": 0.7900390625}, {"start": 1942.11, "end": 1943.51, "word": " it", "probability": 0.916015625}, {"start": 1943.51, "end": 1943.79, "word": " clear?", "probability": 0.89501953125}, {"start": 1945.67, "end": 1945.99, "word": " Okay.", "probability": 0.2266845703125}, {"start": 1947.37, "end": 1948.19, "word": " We", "probability": 0.94189453125}, {"start": 1948.19, "end": 1948.55, "word": " have", "probability": 0.9521484375}, {"start": 1948.55, "end": 1948.89, "word": " the", "probability": 0.87109375}, {"start": 1948.89, "end": 1949.11, "word": " A", "probability": 0.10528564453125}, {"start": 1949.11, "end": 1950.43, "word": " sound", "probability": 0.91650390625}, {"start": 1950.43, "end": 1952.05, "word": " as", "probability": 0.58447265625}, {"start": 1952.05, "end": 1952.53, "word": " in", "probability": 0.939453125}, {"start": 1952.53, "end": 1953.73, "word": " attack.", "probability": 0.80224609375}, {"start": 1954.93, "end": 1955.85, "word": " Attack.", "probability": 0.505859375}, {"start": 1956.97, "end": 1957.53, "word": " Banana.", "probability": 0.82666015625}, {"start": 1958.51, "end": 1958.75, "word": " Bad.", "probability": 0.5732421875}], "temperature": 1.0}, {"id": 71, "seek": 198764, "start": 1963.02, "end": 1987.64, "text": " So you have quite long, short vowel. We have the uh sound, as in run, uncle, cut, hut, above. You find these or this sound available in these words.", "tokens": [407, 291, 362, 1596, 938, 11, 2099, 29410, 13, 492, 362, 264, 2232, 1626, 11, 382, 294, 1190, 11, 9153, 11, 1723, 11, 36755, 11, 3673, 13, 509, 915, 613, 420, 341, 1626, 2435, 294, 613, 2283, 13], "avg_logprob": -0.29507210774299425, "compression_ratio": 1.3070175438596492, "no_speech_prob": 0.0, "words": [{"start": 1963.02, "end": 1963.3, "word": " So", "probability": 0.72998046875}, {"start": 1963.3, "end": 1963.5, "word": " you", "probability": 0.78076171875}, {"start": 1963.5, "end": 1963.86, "word": " have", "probability": 0.9443359375}, {"start": 1963.86, "end": 1964.82, "word": " quite", "probability": 0.55078125}, {"start": 1964.82, "end": 1965.4, "word": " long,", "probability": 0.8134765625}, {"start": 1965.9, "end": 1966.76, "word": " short", "probability": 0.95703125}, {"start": 1966.76, "end": 1967.06, "word": " vowel.", "probability": 0.7568359375}, {"start": 1967.98, "end": 1968.5, "word": " We", "probability": 0.93798828125}, {"start": 1968.5, "end": 1968.78, "word": " have", "probability": 0.951171875}, {"start": 1968.78, "end": 1969.1, "word": " the", "probability": 0.88916015625}, {"start": 1969.1, "end": 1969.32, "word": " uh", "probability": 0.06475830078125}, {"start": 1969.32, "end": 1971.26, "word": " sound,", "probability": 0.83154296875}, {"start": 1972.0, "end": 1972.46, "word": " as", "probability": 0.9375}, {"start": 1972.46, "end": 1972.72, "word": " in", "probability": 0.951171875}, {"start": 1972.72, "end": 1973.3, "word": " run,", "probability": 0.79443359375}, {"start": 1974.26, "end": 1974.76, "word": " uncle,", "probability": 0.88623046875}, {"start": 1977.56, "end": 1977.94, "word": " cut,", "probability": 0.79833984375}, {"start": 1978.96, "end": 1979.32, "word": " hut,", "probability": 0.8681640625}, {"start": 1981.02, "end": 1981.54, "word": " above.", "probability": 0.98046875}, {"start": 1983.74, "end": 1984.48, "word": " You", "probability": 0.325439453125}, {"start": 1984.48, "end": 1984.82, "word": " find", "probability": 0.7548828125}, {"start": 1984.82, "end": 1985.3, "word": " these", "probability": 0.6845703125}, {"start": 1985.3, "end": 1985.64, "word": " or", "probability": 0.6416015625}, {"start": 1985.64, "end": 1985.88, "word": " this", "probability": 0.88623046875}, {"start": 1985.88, "end": 1986.16, "word": " sound", "probability": 0.85791015625}, {"start": 1986.16, "end": 1986.62, "word": " available", "probability": 0.82470703125}, {"start": 1986.62, "end": 1986.96, "word": " in", "probability": 0.9443359375}, {"start": 1986.96, "end": 1987.24, "word": " these", "probability": 0.86083984375}, {"start": 1987.24, "end": 1987.64, "word": " words.", "probability": 0.85888671875}], "temperature": 1.0}, {"id": 72, "seek": 202292, "start": 1993.78, "end": 2022.92, "text": " So you find these sounds, I mean this sound, available in run, uncle, above, cut, hut, is not available in Arabic. So it is problematic. It is replaced by the Hamza in Arabic. So you have your students or you yourselves pronounce it as above,", "tokens": [407, 291, 915, 613, 3263, 11, 286, 914, 341, 1626, 11, 2435, 294, 1190, 11, 9153, 11, 3673, 11, 1723, 11, 36755, 11, 307, 406, 2435, 294, 19938, 13, 407, 309, 307, 19011, 13, 467, 307, 10772, 538, 264, 8234, 2394, 294, 19938, 13, 407, 291, 362, 428, 1731, 420, 291, 14791, 19567, 309, 382, 3673, 11], "avg_logprob": -0.19935344930352836, "compression_ratio": 1.5677419354838709, "no_speech_prob": 0.0, "words": [{"start": 1993.78, "end": 1994.04, "word": " So", "probability": 0.7685546875}, {"start": 1994.04, "end": 1994.18, "word": " you", "probability": 0.71044921875}, {"start": 1994.18, "end": 1994.5, "word": " find", "probability": 0.72705078125}, {"start": 1994.5, "end": 1995.16, "word": " these", "probability": 0.857421875}, {"start": 1995.16, "end": 1997.7, "word": " sounds,", "probability": 0.8603515625}, {"start": 1997.92, "end": 1998.04, "word": " I", "probability": 0.9189453125}, {"start": 1998.04, "end": 1998.16, "word": " mean", "probability": 0.9697265625}, {"start": 1998.16, "end": 1998.38, "word": " this", "probability": 0.7294921875}, {"start": 1998.38, "end": 1998.82, "word": " sound,", "probability": 0.87451171875}, {"start": 1999.2, "end": 2000.42, "word": " available", "probability": 0.251953125}, {"start": 2000.42, "end": 2001.1, "word": " in", "probability": 0.94482421875}, {"start": 2001.1, "end": 2001.68, "word": " run,", "probability": 0.787109375}, {"start": 2002.8, "end": 2003.38, "word": " uncle,", "probability": 0.90380859375}, {"start": 2005.12, "end": 2005.6, "word": " above,", "probability": 0.98388671875}, {"start": 2007.24, "end": 2007.62, "word": " cut,", "probability": 0.85888671875}, {"start": 2008.5, "end": 2008.86, "word": " hut,", "probability": 0.70849609375}, {"start": 2009.34, "end": 2010.32, "word": " is", "probability": 0.2529296875}, {"start": 2010.32, "end": 2010.52, "word": " not", "probability": 0.95458984375}, {"start": 2010.52, "end": 2010.96, "word": " available", "probability": 0.84423828125}, {"start": 2010.96, "end": 2011.26, "word": " in", "probability": 0.95556640625}, {"start": 2011.26, "end": 2011.56, "word": " Arabic.", "probability": 0.91064453125}, {"start": 2012.5, "end": 2012.86, "word": " So", "probability": 0.9482421875}, {"start": 2012.86, "end": 2013.02, "word": " it", "probability": 0.8564453125}, {"start": 2013.02, "end": 2013.22, "word": " is", "probability": 0.943359375}, {"start": 2013.22, "end": 2013.74, "word": " problematic.", "probability": 0.8662109375}, {"start": 2014.48, "end": 2014.68, "word": " It", "probability": 0.96484375}, {"start": 2014.68, "end": 2014.8, "word": " is", "probability": 0.93408203125}, {"start": 2014.8, "end": 2015.28, "word": " replaced", "probability": 0.888671875}, {"start": 2015.28, "end": 2015.58, "word": " by", "probability": 0.97119140625}, {"start": 2015.58, "end": 2015.76, "word": " the", "probability": 0.89111328125}, {"start": 2015.76, "end": 2016.1, "word": " Hamza", "probability": 0.79833984375}, {"start": 2016.1, "end": 2016.3, "word": " in", "probability": 0.9453125}, {"start": 2016.3, "end": 2016.58, "word": " Arabic.", "probability": 0.91796875}, {"start": 2017.22, "end": 2017.34, "word": " So", "probability": 0.94873046875}, {"start": 2017.34, "end": 2017.48, "word": " you", "probability": 0.90234375}, {"start": 2017.48, "end": 2017.8, "word": " have", "probability": 0.93212890625}, {"start": 2017.8, "end": 2018.02, "word": " your", "probability": 0.8662109375}, {"start": 2018.02, "end": 2018.46, "word": " students", "probability": 0.9736328125}, {"start": 2018.46, "end": 2018.9, "word": " or", "probability": 0.67529296875}, {"start": 2018.9, "end": 2019.46, "word": " you", "probability": 0.9267578125}, {"start": 2019.46, "end": 2020.06, "word": " yourselves", "probability": 0.6318359375}, {"start": 2020.06, "end": 2021.52, "word": " pronounce", "probability": 0.80517578125}, {"start": 2021.52, "end": 2022.02, "word": " it", "probability": 0.95751953125}, {"start": 2022.02, "end": 2022.42, "word": " as", "probability": 0.9609375}, {"start": 2022.42, "end": 2022.92, "word": " above,", "probability": 0.77978515625}], "temperature": 1.0}, {"id": 73, "seek": 205233, "start": 2023.77, "end": 2052.33, "text": " You can put your fingers on your necks and try to pronounce it above. If there be movement here, this means that you pronounce the Arabic Hamza. So, it is pronounced from your mouth. Okay? It is not from the glottis. So, we say above. Above.", "tokens": [509, 393, 829, 428, 7350, 322, 428, 408, 2761, 293, 853, 281, 19567, 309, 3673, 13, 759, 456, 312, 3963, 510, 11, 341, 1355, 300, 291, 19567, 264, 19938, 8234, 2394, 13, 407, 11, 309, 307, 23155, 490, 428, 4525, 13, 1033, 30, 467, 307, 406, 490, 264, 1563, 1521, 271, 13, 407, 11, 321, 584, 3673, 13, 32691, 13], "avg_logprob": -0.16982582260350712, "compression_ratio": 1.5031055900621118, "no_speech_prob": 0.0, "words": [{"start": 2023.77, "end": 2023.99, "word": " You", "probability": 0.55908203125}, {"start": 2023.99, "end": 2024.19, "word": " can", "probability": 0.94482421875}, {"start": 2024.19, "end": 2024.37, "word": " put", "probability": 0.927734375}, {"start": 2024.37, "end": 2024.55, "word": " your", "probability": 0.89794921875}, {"start": 2024.55, "end": 2024.95, "word": " fingers", "probability": 0.9462890625}, {"start": 2024.95, "end": 2025.33, "word": " on", "probability": 0.9404296875}, {"start": 2025.33, "end": 2027.03, "word": " your", "probability": 0.8505859375}, {"start": 2027.03, "end": 2028.01, "word": " necks", "probability": 0.7061767578125}, {"start": 2028.01, "end": 2028.89, "word": " and", "probability": 0.763671875}, {"start": 2028.89, "end": 2029.15, "word": " try", "probability": 0.9326171875}, {"start": 2029.15, "end": 2029.57, "word": " to", "probability": 0.974609375}, {"start": 2029.57, "end": 2030.11, "word": " pronounce", "probability": 0.92724609375}, {"start": 2030.11, "end": 2030.59, "word": " it", "probability": 0.95751953125}, {"start": 2030.59, "end": 2031.63, "word": " above.", "probability": 0.7587890625}, {"start": 2032.29, "end": 2032.75, "word": " If", "probability": 0.96923828125}, {"start": 2032.75, "end": 2032.93, "word": " there", "probability": 0.91845703125}, {"start": 2032.93, "end": 2033.17, "word": " be", "probability": 0.57861328125}, {"start": 2033.17, "end": 2034.51, "word": " movement", "probability": 0.9326171875}, {"start": 2034.51, "end": 2035.57, "word": " here,", "probability": 0.80517578125}, {"start": 2036.03, "end": 2036.27, "word": " this", "probability": 0.93798828125}, {"start": 2036.27, "end": 2036.59, "word": " means", "probability": 0.931640625}, {"start": 2036.59, "end": 2036.99, "word": " that", "probability": 0.935546875}, {"start": 2036.99, "end": 2038.11, "word": " you", "probability": 0.94970703125}, {"start": 2038.11, "end": 2038.47, "word": " pronounce", "probability": 0.80126953125}, {"start": 2038.47, "end": 2038.67, "word": " the", "probability": 0.88623046875}, {"start": 2038.67, "end": 2039.15, "word": " Arabic", "probability": 0.9248046875}, {"start": 2039.15, "end": 2039.95, "word": " Hamza.", "probability": 0.72900390625}, {"start": 2041.09, "end": 2041.45, "word": " So,", "probability": 0.92431640625}, {"start": 2042.19, "end": 2042.69, "word": " it", "probability": 0.95556640625}, {"start": 2042.69, "end": 2042.87, "word": " is", "probability": 0.94384765625}, {"start": 2042.87, "end": 2043.17, "word": " pronounced", "probability": 0.84765625}, {"start": 2043.17, "end": 2043.49, "word": " from", "probability": 0.890625}, {"start": 2043.49, "end": 2043.73, "word": " your", "probability": 0.87841796875}, {"start": 2043.73, "end": 2044.17, "word": " mouth.", "probability": 0.95263671875}, {"start": 2045.41, "end": 2045.89, "word": " Okay?", "probability": 0.7294921875}, {"start": 2046.17, "end": 2046.35, "word": " It", "probability": 0.9697265625}, {"start": 2046.35, "end": 2046.47, "word": " is", "probability": 0.93212890625}, {"start": 2046.47, "end": 2046.63, "word": " not", "probability": 0.94580078125}, {"start": 2046.63, "end": 2046.87, "word": " from", "probability": 0.88330078125}, {"start": 2046.87, "end": 2047.05, "word": " the", "probability": 0.92333984375}, {"start": 2047.05, "end": 2047.53, "word": " glottis.", "probability": 0.9401041666666666}, {"start": 2048.29, "end": 2048.51, "word": " So,", "probability": 0.96044921875}, {"start": 2048.55, "end": 2048.71, "word": " we", "probability": 0.77099609375}, {"start": 2048.71, "end": 2049.01, "word": " say", "probability": 0.947265625}, {"start": 2049.01, "end": 2050.13, "word": " above.", "probability": 0.6650390625}, {"start": 2051.85, "end": 2052.33, "word": " Above.", "probability": 0.921875}], "temperature": 1.0}, {"id": 74, "seek": 207371, "start": 2053.18, "end": 2073.72, "text": " About. Yes, we say uncle, uncle, not uncle. So this is Arabic. Okay. We have the oh sound. Oh is not found in Arabic as well as available in cough.", "tokens": [7769, 13, 1079, 11, 321, 584, 9153, 11, 9153, 11, 406, 9153, 13, 407, 341, 307, 19938, 13, 1033, 13, 492, 362, 264, 1954, 1626, 13, 876, 307, 406, 1352, 294, 19938, 382, 731, 382, 2435, 294, 22777, 13], "avg_logprob": -0.2484374888241291, "compression_ratio": 1.2869565217391303, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2053.1800000000003, "end": 2053.82, "word": " About.", "probability": 0.544921875}, {"start": 2058.0, "end": 2058.64, "word": " Yes,", "probability": 0.87451171875}, {"start": 2059.22, "end": 2059.4, "word": " we", "probability": 0.9580078125}, {"start": 2059.4, "end": 2059.82, "word": " say", "probability": 0.94873046875}, {"start": 2059.82, "end": 2060.56, "word": " uncle,", "probability": 0.8134765625}, {"start": 2060.9, "end": 2061.88, "word": " uncle,", "probability": 0.91064453125}, {"start": 2062.02, "end": 2062.2, "word": " not", "probability": 0.943359375}, {"start": 2062.2, "end": 2062.86, "word": " uncle.", "probability": 0.83251953125}, {"start": 2063.88, "end": 2064.1, "word": " So", "probability": 0.95947265625}, {"start": 2064.1, "end": 2064.28, "word": " this", "probability": 0.6240234375}, {"start": 2064.28, "end": 2064.44, "word": " is", "probability": 0.96044921875}, {"start": 2064.44, "end": 2064.74, "word": " Arabic.", "probability": 0.91162109375}, {"start": 2066.5, "end": 2067.0, "word": " Okay.", "probability": 0.6474609375}, {"start": 2067.5, "end": 2067.8, "word": " We", "probability": 0.958984375}, {"start": 2067.8, "end": 2068.0, "word": " have", "probability": 0.9501953125}, {"start": 2068.0, "end": 2068.18, "word": " the", "probability": 0.94091796875}, {"start": 2068.18, "end": 2068.34, "word": " oh", "probability": 0.13623046875}, {"start": 2068.34, "end": 2068.8, "word": " sound.", "probability": 0.81689453125}, {"start": 2069.58, "end": 2069.74, "word": " Oh", "probability": 0.9365234375}, {"start": 2069.74, "end": 2070.0, "word": " is", "probability": 0.92333984375}, {"start": 2070.0, "end": 2070.2, "word": " not", "probability": 0.94970703125}, {"start": 2070.2, "end": 2070.48, "word": " found", "probability": 0.90576171875}, {"start": 2070.48, "end": 2070.64, "word": " in", "probability": 0.94873046875}, {"start": 2070.64, "end": 2070.9, "word": " Arabic", "probability": 0.92578125}, {"start": 2070.9, "end": 2071.18, "word": " as", "probability": 0.95166015625}, {"start": 2071.18, "end": 2071.4, "word": " well", "probability": 0.943359375}, {"start": 2071.4, "end": 2072.58, "word": " as", "probability": 0.68359375}, {"start": 2072.58, "end": 2072.98, "word": " available", "probability": 0.826171875}, {"start": 2072.98, "end": 2073.4, "word": " in", "probability": 0.9521484375}, {"start": 2073.4, "end": 2073.72, "word": " cough.", "probability": 0.46533203125}], "temperature": 1.0}, {"id": 75, "seek": 209602, "start": 2074.48, "end": 2096.02, "text": " Dog knowledge. Okay? It's charged vowel. So you have your students find difficulty in pronouncing these words. So they come out with interlingual errors, interlingual mistakes, or intralingual mistakes. Inter or intra? 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This comes out with interlingual error or interlingual mistake. We also have the long vowels. Okay. They are longer than the short vowels. Okay. Yes. So these long vowels are nearly five in English.", "tokens": [295, 3669, 5969, 436, 8969, 264, 8234, 2394, 13, 639, 1487, 484, 365, 728, 1688, 901, 6713, 420, 728, 1688, 901, 6146, 13, 492, 611, 362, 264, 938, 44972, 13, 1033, 13, 814, 366, 2854, 813, 264, 2099, 44972, 13, 1033, 13, 1079, 13, 407, 613, 938, 44972, 366, 6217, 1732, 294, 3669, 13], "avg_logprob": -0.16548295237801292, "compression_ratio": 1.5686274509803921, "no_speech_prob": 0.0, "words": [{"start": 2097.38, "end": 2097.68, "word": " of", "probability": 0.53125}, {"start": 2097.68, "end": 2098.16, "word": " English", "probability": 0.97265625}, {"start": 2098.16, "end": 2099.16, "word": " unless", "probability": 0.474609375}, {"start": 2099.16, "end": 2099.74, "word": " they", "probability": 0.8955078125}, {"start": 2099.74, "end": 2100.66, "word": " insert", "probability": 0.9541015625}, {"start": 2100.66, "end": 2101.5, "word": " the", "probability": 0.90283203125}, {"start": 2101.5, "end": 2101.86, "word": " Hamza.", "probability": 0.80029296875}, {"start": 2102.44, "end": 2102.66, "word": " This", "probability": 0.88330078125}, {"start": 2102.66, "end": 2102.98, "word": " comes", "probability": 0.8857421875}, {"start": 2102.98, "end": 2103.4, "word": " out", "probability": 0.87548828125}, {"start": 2103.4, "end": 2103.7, "word": " with", "probability": 0.86962890625}, {"start": 2103.7, "end": 2104.44, "word": " interlingual", "probability": 0.8575846354166666}, {"start": 2104.44, "end": 2104.74, "word": " error", "probability": 0.83642578125}, {"start": 2104.74, "end": 2105.3, "word": " or", "probability": 0.77001953125}, {"start": 2105.3, "end": 2105.9, "word": " interlingual", "probability": 0.95849609375}, {"start": 2105.9, "end": 2106.36, "word": " mistake.", "probability": 0.9326171875}, {"start": 2106.84, "end": 2107.04, "word": " We", "probability": 0.9638671875}, {"start": 2107.04, "end": 2107.34, "word": " also", "probability": 0.88134765625}, {"start": 2107.34, "end": 2107.78, "word": " have", "probability": 0.94970703125}, {"start": 2107.78, "end": 2108.84, "word": " the", "probability": 0.91748046875}, {"start": 2108.84, "end": 2109.14, "word": " long", "probability": 0.9248046875}, {"start": 2109.14, "end": 2109.56, "word": " vowels.", "probability": 0.98779296875}, {"start": 2111.14, "end": 2111.5, "word": " Okay.", "probability": 0.47412109375}, {"start": 2112.38, "end": 2112.96, "word": " They", "probability": 0.82275390625}, {"start": 2112.96, "end": 2113.14, "word": " are", "probability": 0.9375}, {"start": 2113.14, "end": 2113.44, "word": " longer", "probability": 0.9306640625}, {"start": 2113.44, "end": 2113.9, "word": " than", "probability": 0.947265625}, {"start": 2113.9, "end": 2114.7, "word": " the", "probability": 0.9169921875}, {"start": 2114.7, "end": 2115.04, "word": " short", "probability": 0.9638671875}, {"start": 2115.04, "end": 2115.46, "word": " vowels.", "probability": 0.98388671875}, {"start": 2116.32, "end": 2116.58, "word": " Okay.", "probability": 0.779296875}, {"start": 2118.34, "end": 2118.88, "word": " Yes.", "probability": 0.9462890625}, {"start": 2119.76, "end": 2120.28, "word": " So", "probability": 0.951171875}, {"start": 2120.28, "end": 2121.98, "word": " these", "probability": 0.61474609375}, {"start": 2121.98, "end": 2123.4, "word": " long", "probability": 0.919921875}, {"start": 2123.4, "end": 2123.9, "word": " vowels", "probability": 0.98388671875}, {"start": 2123.9, "end": 2124.54, "word": " are", "probability": 0.93505859375}, {"start": 2124.54, "end": 2124.84, "word": " nearly", "probability": 0.9033203125}, {"start": 2124.84, "end": 2125.4, "word": " five", "probability": 0.845703125}, {"start": 2125.4, "end": 2125.7, "word": " in", "probability": 0.9521484375}, {"start": 2125.7, "end": 2126.06, "word": " English.", "probability": 0.9765625}], "temperature": 1.0}, {"id": 77, "seek": 215651, "start": 2126.99, "end": 2156.51, "text": " Okay. We have long vowels in Arabic as well, but they are less than English. So let's see this. The first long vowel, the first English long vowel, E, as in key, cheese, police, police. So you have your students say, for example, police. This is interlingual error.", "tokens": [1033, 13, 492, 362, 938, 44972, 294, 19938, 382, 731, 11, 457, 436, 366, 1570, 813, 3669, 13, 407, 718, 311, 536, 341, 13, 440, 700, 938, 29410, 11, 264, 700, 3669, 938, 29410, 11, 462, 11, 382, 294, 2141, 11, 5399, 11, 3804, 11, 3804, 13, 407, 291, 362, 428, 1731, 584, 11, 337, 1365, 11, 3804, 13, 639, 307, 560, 260, 1688, 901, 6713, 13], "avg_logprob": -0.16210937828702085, "compression_ratio": 1.5647058823529412, "no_speech_prob": 0.0, "words": [{"start": 2126.99, "end": 2127.37, "word": " Okay.", "probability": 0.54443359375}, {"start": 2128.11, "end": 2128.61, "word": " We", "probability": 0.95654296875}, {"start": 2128.61, "end": 2128.85, "word": " have", "probability": 0.951171875}, {"start": 2128.85, "end": 2129.17, "word": " long", "probability": 0.93505859375}, {"start": 2129.17, "end": 2129.43, "word": " vowels", "probability": 0.986328125}, {"start": 2129.43, "end": 2129.61, "word": " in", "probability": 0.94091796875}, {"start": 2129.61, "end": 2129.89, "word": " Arabic", "probability": 0.9169921875}, {"start": 2129.89, "end": 2130.19, "word": " as", "probability": 0.9423828125}, {"start": 2130.19, "end": 2130.39, "word": " well,", "probability": 0.9482421875}, {"start": 2130.99, "end": 2131.75, "word": " but", "probability": 0.93310546875}, {"start": 2131.75, "end": 2132.97, "word": " they", "probability": 0.8583984375}, {"start": 2132.97, "end": 2133.21, "word": " are", "probability": 0.94384765625}, {"start": 2133.21, "end": 2133.43, "word": " less", "probability": 0.9541015625}, {"start": 2133.43, "end": 2133.77, "word": " than", "probability": 0.953125}, {"start": 2133.77, "end": 2134.35, "word": " English.", "probability": 0.9765625}, {"start": 2134.87, "end": 2135.39, "word": " So", "probability": 0.9560546875}, {"start": 2135.39, "end": 2135.77, "word": " let's", "probability": 0.791015625}, {"start": 2135.77, "end": 2135.97, "word": " see", "probability": 0.9228515625}, {"start": 2135.97, "end": 2136.29, "word": " this.", "probability": 0.94287109375}, {"start": 2137.09, "end": 2137.19, "word": " The", "probability": 0.89404296875}, {"start": 2137.19, "end": 2137.51, "word": " first", "probability": 0.88037109375}, {"start": 2137.51, "end": 2137.83, "word": " long", "probability": 0.92724609375}, {"start": 2137.83, "end": 2138.19, "word": " vowel,", "probability": 0.97705078125}, {"start": 2138.97, "end": 2139.11, "word": " the", "probability": 0.91064453125}, {"start": 2139.11, "end": 2139.33, "word": " first", "probability": 0.8525390625}, {"start": 2139.33, "end": 2139.67, "word": " English", "probability": 0.9794921875}, {"start": 2139.67, "end": 2139.97, "word": " long", "probability": 0.92529296875}, {"start": 2139.97, "end": 2140.35, "word": " vowel,", "probability": 0.9755859375}, {"start": 2140.45, "end": 2140.75, "word": " E,", "probability": 0.66650390625}, {"start": 2141.63, "end": 2142.45, "word": " as", "probability": 0.962890625}, {"start": 2142.45, "end": 2143.01, "word": " in", "probability": 0.9521484375}, {"start": 2143.01, "end": 2144.39, "word": " key,", "probability": 0.68408203125}, {"start": 2145.17, "end": 2145.79, "word": " cheese,", "probability": 0.859375}, {"start": 2146.55, "end": 2147.11, "word": " police,", "probability": 0.92041015625}, {"start": 2147.85, "end": 2148.41, "word": " police.", "probability": 0.9169921875}, {"start": 2148.67, "end": 2148.99, "word": " So", "probability": 0.9609375}, {"start": 2148.99, "end": 2149.11, "word": " you", "probability": 0.8720703125}, {"start": 2149.11, "end": 2149.27, "word": " have", "probability": 0.9140625}, {"start": 2149.27, "end": 2149.43, "word": " your", "probability": 0.8359375}, {"start": 2149.43, "end": 2149.71, "word": " students", "probability": 0.79248046875}, {"start": 2149.71, "end": 2150.09, "word": " say,", "probability": 0.93994140625}, {"start": 2150.19, "end": 2150.27, "word": " for", "probability": 0.95556640625}, {"start": 2150.27, "end": 2150.73, "word": " example,", "probability": 0.97509765625}, {"start": 2151.27, "end": 2151.65, "word": " police.", "probability": 0.7890625}, {"start": 2153.73, "end": 2154.45, "word": " This", "probability": 0.89453125}, {"start": 2154.45, "end": 2155.31, "word": " is", "probability": 0.95166015625}, {"start": 2155.31, "end": 2156.23, "word": " interlingual", "probability": 0.73541259765625}, {"start": 2156.23, "end": 2156.51, "word": " error.", "probability": 0.88232421875}], "temperature": 1.0}, {"id": 78, "seek": 217880, "start": 2158.5, "end": 2178.8, "text": " I say, for example, they mix between this sound, this long vowel and the short vowel. So if I ask you about your nationality, what do you say? You are Palestinians. Some of you say, I am Palestinian, which is wrong. Palestinians, Palestinian.", "tokens": [286, 584, 11, 337, 1365, 11, 436, 2890, 1296, 341, 1626, 11, 341, 938, 29410, 293, 264, 2099, 29410, 13, 407, 498, 286, 1029, 291, 466, 428, 4048, 507, 11, 437, 360, 291, 584, 30, 509, 366, 34745, 13, 2188, 295, 291, 584, 11, 286, 669, 28202, 11, 597, 307, 2085, 13, 34745, 11, 28202, 13], "avg_logprob": -0.1748903571513661, "compression_ratio": 1.5576923076923077, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2158.5, "end": 2159.08, "word": " I", "probability": 0.32861328125}, {"start": 2159.08, "end": 2159.4, "word": " say,", "probability": 0.78759765625}, {"start": 2159.56, "end": 2159.56, "word": " for", "probability": 0.92578125}, {"start": 2159.56, "end": 2159.82, "word": " example,", "probability": 0.95458984375}, {"start": 2159.88, "end": 2160.02, "word": " they", "probability": 0.64306640625}, {"start": 2160.02, "end": 2160.38, "word": " mix", "probability": 0.9228515625}, {"start": 2160.38, "end": 2161.28, "word": " between", "probability": 0.73046875}, {"start": 2161.28, "end": 2161.62, "word": " this", "probability": 0.93798828125}, {"start": 2161.62, "end": 2161.86, "word": " sound,", "probability": 0.7705078125}, {"start": 2161.96, "end": 2162.06, "word": " this", "probability": 0.94482421875}, {"start": 2162.06, "end": 2162.34, "word": " long", "probability": 0.93212890625}, {"start": 2162.34, "end": 2162.68, "word": " vowel", "probability": 0.9765625}, {"start": 2162.68, "end": 2163.4, "word": " and", "probability": 0.63818359375}, {"start": 2163.4, "end": 2163.54, "word": " the", "probability": 0.6787109375}, {"start": 2163.54, "end": 2163.78, "word": " short", "probability": 0.9599609375}, {"start": 2163.78, "end": 2164.1, "word": " vowel.", "probability": 0.97509765625}, {"start": 2164.76, "end": 2164.96, "word": " So", "probability": 0.93310546875}, {"start": 2164.96, "end": 2165.14, "word": " if", "probability": 0.68408203125}, {"start": 2165.14, "end": 2165.3, "word": " I", "probability": 0.99560546875}, {"start": 2165.3, "end": 2165.56, "word": " ask", "probability": 0.8955078125}, {"start": 2165.56, "end": 2165.68, "word": " you", "probability": 0.96337890625}, {"start": 2165.68, "end": 2165.96, "word": " about", "probability": 0.908203125}, {"start": 2165.96, "end": 2166.2, "word": " your", "probability": 0.89208984375}, {"start": 2166.2, "end": 2166.92, "word": " nationality,", "probability": 0.974609375}, {"start": 2166.98, "end": 2167.1, "word": " what", "probability": 0.94189453125}, {"start": 2167.1, "end": 2167.18, "word": " do", "probability": 0.94873046875}, {"start": 2167.18, "end": 2167.28, "word": " you", "probability": 0.96435546875}, {"start": 2167.28, "end": 2167.48, "word": " say?", "probability": 0.9501953125}, {"start": 2168.9, "end": 2169.3, "word": " You", "probability": 0.65234375}, {"start": 2169.3, "end": 2169.6, "word": " are", "probability": 0.94287109375}, {"start": 2169.6, "end": 2170.18, "word": " Palestinians.", "probability": 0.71044921875}, {"start": 2171.08, "end": 2171.66, "word": " Some", "probability": 0.88525390625}, {"start": 2171.66, "end": 2171.82, "word": " of", "probability": 0.96875}, {"start": 2171.82, "end": 2171.96, "word": " you", "probability": 0.966796875}, {"start": 2171.96, "end": 2172.32, "word": " say,", "probability": 0.94873046875}, {"start": 2172.9, "end": 2173.02, "word": " I", "probability": 0.822265625}, {"start": 2173.02, "end": 2173.28, "word": " am", "probability": 0.95556640625}, {"start": 2173.28, "end": 2173.98, "word": " Palestinian,", "probability": 0.7421875}, {"start": 2174.44, "end": 2174.76, "word": " which", "probability": 0.9560546875}, {"start": 2174.76, "end": 2174.9, "word": " is", "probability": 0.94921875}, {"start": 2174.9, "end": 2175.26, "word": " wrong.", "probability": 0.9296875}, {"start": 2176.9, "end": 2177.48, "word": " Palestinians,", "probability": 0.79541015625}, {"start": 2178.1, "end": 2178.8, "word": " Palestinian.", "probability": 0.736328125}], "temperature": 1.0}, {"id": 79, "seek": 220826, "start": 2179.64, "end": 2208.26, "text": " It is short vowel as in set, six, not seat, meet. So don't say Palestinians. It is Palestinians. Otherwise, you commit interlingual or interlingual mistake? Interlingual. You mix between the sounds of English.", "tokens": [467, 307, 2099, 29410, 382, 294, 992, 11, 2309, 11, 406, 6121, 11, 1677, 13, 407, 500, 380, 584, 34745, 13, 467, 307, 34745, 13, 10328, 11, 291, 5599, 728, 1688, 901, 420, 560, 260, 1688, 901, 6146, 30, 5751, 1688, 901, 13, 509, 2890, 1296, 264, 3263, 295, 3669, 13], "avg_logprob": -0.20703124770751366, "compression_ratio": 1.4788732394366197, "no_speech_prob": 0.0, "words": [{"start": 2179.64, "end": 2179.88, "word": " It", "probability": 0.8974609375}, {"start": 2179.88, "end": 2180.08, "word": " is", "probability": 0.8271484375}, {"start": 2180.08, "end": 2180.4, "word": " short", "probability": 0.87060546875}, {"start": 2180.4, "end": 2180.8, "word": " vowel", "probability": 0.9658203125}, {"start": 2180.8, "end": 2183.06, "word": " as", "probability": 0.143798828125}, {"start": 2183.06, "end": 2183.74, "word": " in", "probability": 0.9541015625}, {"start": 2183.74, "end": 2185.48, "word": " set,", "probability": 0.50048828125}, {"start": 2186.18, "end": 2186.84, "word": " six,", "probability": 0.69677734375}, {"start": 2187.48, "end": 2187.82, "word": " not", "probability": 0.86181640625}, {"start": 2187.82, "end": 2188.78, "word": " seat,", "probability": 0.91845703125}, {"start": 2189.86, "end": 2190.36, "word": " meet.", "probability": 0.873046875}, {"start": 2190.82, "end": 2191.4, "word": " So", "probability": 0.947265625}, {"start": 2191.4, "end": 2191.58, "word": " don't", "probability": 0.88671875}, {"start": 2191.58, "end": 2191.84, "word": " say", "probability": 0.9599609375}, {"start": 2191.84, "end": 2192.68, "word": " Palestinians.", "probability": 0.70556640625}, {"start": 2193.32, "end": 2193.56, "word": " It", "probability": 0.9609375}, {"start": 2193.56, "end": 2193.74, "word": " is", "probability": 0.95263671875}, {"start": 2193.74, "end": 2194.38, "word": " Palestinians.", "probability": 0.8095703125}, {"start": 2196.62, "end": 2197.58, "word": " Otherwise,", "probability": 0.411865234375}, {"start": 2197.9, "end": 2198.0, "word": " you", "probability": 0.962890625}, {"start": 2198.0, "end": 2198.48, "word": " commit", "probability": 0.76611328125}, {"start": 2198.48, "end": 2199.88, "word": " interlingual", "probability": 0.8875325520833334}, {"start": 2199.88, "end": 2200.22, "word": " or", "probability": 0.966796875}, {"start": 2200.22, "end": 2200.96, "word": " interlingual", "probability": 0.8299560546875}, {"start": 2200.96, "end": 2201.5, "word": " mistake?", "probability": 0.9345703125}, {"start": 2204.76, "end": 2205.72, "word": " Interlingual.", "probability": 0.8894856770833334}, {"start": 2205.96, "end": 2206.8, "word": " You", "probability": 0.869140625}, {"start": 2206.8, "end": 2207.02, "word": " mix", "probability": 0.93212890625}, {"start": 2207.02, "end": 2207.36, "word": " between", "probability": 0.86083984375}, {"start": 2207.36, "end": 2207.54, "word": " the", "probability": 0.91455078125}, {"start": 2207.54, "end": 2207.8, "word": " sounds", "probability": 0.84716796875}, {"start": 2207.8, "end": 2207.96, "word": " of", "probability": 0.91943359375}, {"start": 2207.96, "end": 2208.26, "word": " English.", "probability": 0.97998046875}], "temperature": 1.0}, {"id": 80, "seek": 223316, "start": 2209.12, "end": 2233.16, "text": " Okay? Arabic does not interfere. So we have the long vowel, the Arabic long vowel E as in feel elephant. This is called also kasra in Arabic plus the sound E. We have", "tokens": [1033, 30, 19938, 775, 406, 23946, 13, 407, 321, 362, 264, 938, 29410, 11, 264, 19938, 938, 29410, 462, 382, 294, 841, 19791, 13, 639, 307, 1219, 611, 19173, 424, 294, 19938, 1804, 264, 1626, 462, 13, 492, 362], "avg_logprob": -0.24257812052965164, "compression_ratio": 1.336, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2209.12, "end": 2209.46, "word": " Okay?", "probability": 0.32568359375}, {"start": 2209.88, "end": 2210.3, "word": " Arabic", "probability": 0.943359375}, {"start": 2210.3, "end": 2210.54, "word": " does", "probability": 0.9775390625}, {"start": 2210.54, "end": 2210.74, "word": " not", "probability": 0.9560546875}, {"start": 2210.74, "end": 2211.18, "word": " interfere.", "probability": 0.921875}, {"start": 2211.92, "end": 2212.12, "word": " So", "probability": 0.9443359375}, {"start": 2212.12, "end": 2212.26, "word": " we", "probability": 0.52783203125}, {"start": 2212.26, "end": 2212.42, "word": " have", "probability": 0.95458984375}, {"start": 2212.42, "end": 2212.58, "word": " the", "probability": 0.90625}, {"start": 2212.58, "end": 2212.84, "word": " long", "probability": 0.92333984375}, {"start": 2212.84, "end": 2213.2, "word": " vowel,", "probability": 0.98046875}, {"start": 2213.62, "end": 2213.74, "word": " the", "probability": 0.84716796875}, {"start": 2213.74, "end": 2214.0, "word": " Arabic", "probability": 0.9111328125}, {"start": 2214.0, "end": 2214.34, "word": " long", "probability": 0.9228515625}, {"start": 2214.34, "end": 2214.72, "word": " vowel", "probability": 0.97412109375}, {"start": 2214.72, "end": 2215.08, "word": " E", "probability": 0.3740234375}, {"start": 2215.08, "end": 2216.48, "word": " as", "probability": 0.51708984375}, {"start": 2216.48, "end": 2216.82, "word": " in", "probability": 0.9384765625}, {"start": 2216.82, "end": 2217.58, "word": " feel", "probability": 0.418212890625}, {"start": 2217.58, "end": 2218.78, "word": " elephant.", "probability": 0.853515625}, {"start": 2219.48, "end": 2220.18, "word": " This", "probability": 0.892578125}, {"start": 2220.18, "end": 2220.34, "word": " is", "probability": 0.95654296875}, {"start": 2220.34, "end": 2220.64, "word": " called", "probability": 0.89208984375}, {"start": 2220.64, "end": 2221.22, "word": " also", "probability": 0.876953125}, {"start": 2221.22, "end": 2221.94, "word": " kasra", "probability": 0.5872802734375}, {"start": 2221.94, "end": 2222.12, "word": " in", "probability": 0.9443359375}, {"start": 2222.12, "end": 2222.52, "word": " Arabic", "probability": 0.91064453125}, {"start": 2222.52, "end": 2228.2, "word": " plus", "probability": 0.426513671875}, {"start": 2228.2, "end": 2229.0, "word": " the", "probability": 0.921875}, {"start": 2229.0, "end": 2229.4, "word": " sound", "probability": 0.8876953125}, {"start": 2229.4, "end": 2230.18, "word": " E.", "probability": 0.8388671875}, {"start": 2231.96, "end": 2232.76, "word": " We", "probability": 0.939453125}, {"start": 2232.76, "end": 2233.16, "word": " have", "probability": 0.95166015625}], "temperature": 1.0}, {"id": 81, "seek": 225764, "start": 2235.68, "end": 2257.64, "text": " OO sound. The OO sound. This is English long vowel as in food, rude, soup. Okay. We have the Arabic OO long vowel as in tool. Okay. So", "tokens": [422, 46, 1626, 13, 440, 422, 46, 1626, 13, 639, 307, 3669, 938, 29410, 382, 294, 1755, 11, 18895, 11, 7884, 13, 1033, 13, 492, 362, 264, 19938, 422, 46, 938, 29410, 382, 294, 2290, 13, 1033, 13, 407], "avg_logprob": -0.310351574420929, "compression_ratio": 1.3235294117647058, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2235.68, "end": 2236.4, "word": " OO", "probability": 0.2860107421875}, {"start": 2236.4, "end": 2237.02, "word": " sound.", "probability": 0.8779296875}, {"start": 2237.38, "end": 2237.64, "word": " The", "probability": 0.77392578125}, {"start": 2237.64, "end": 2237.9, "word": " OO", "probability": 0.947265625}, {"start": 2237.9, "end": 2238.34, "word": " sound.", "probability": 0.8837890625}, {"start": 2239.2, "end": 2239.2, "word": " This", "probability": 0.857421875}, {"start": 2239.2, "end": 2239.34, "word": " is", "probability": 0.9541015625}, {"start": 2239.34, "end": 2239.72, "word": " English", "probability": 0.9619140625}, {"start": 2239.72, "end": 2240.06, "word": " long", "probability": 0.69482421875}, {"start": 2240.06, "end": 2240.42, "word": " vowel", "probability": 0.9755859375}, {"start": 2240.42, "end": 2240.7, "word": " as", "probability": 0.888671875}, {"start": 2240.7, "end": 2240.88, "word": " in", "probability": 0.9453125}, {"start": 2240.88, "end": 2241.36, "word": " food,", "probability": 0.9052734375}, {"start": 2242.2, "end": 2242.64, "word": " rude,", "probability": 0.35693359375}, {"start": 2243.34, "end": 2243.78, "word": " soup.", "probability": 0.9033203125}, {"start": 2244.52, "end": 2244.66, "word": " Okay.", "probability": 0.7998046875}, {"start": 2245.44, "end": 2246.36, "word": " We", "probability": 0.9560546875}, {"start": 2246.36, "end": 2246.56, "word": " have", "probability": 0.95263671875}, {"start": 2246.56, "end": 2246.72, "word": " the", "probability": 0.92529296875}, {"start": 2246.72, "end": 2247.18, "word": " Arabic", "probability": 0.91357421875}, {"start": 2247.18, "end": 2249.24, "word": " OO", "probability": 0.76220703125}, {"start": 2249.24, "end": 2250.26, "word": " long", "probability": 0.68603515625}, {"start": 2250.26, "end": 2250.68, "word": " vowel", "probability": 0.97509765625}, {"start": 2250.68, "end": 2251.08, "word": " as", "probability": 0.8994140625}, {"start": 2251.08, "end": 2251.54, "word": " in", "probability": 0.93603515625}, {"start": 2251.54, "end": 2252.24, "word": " tool.", "probability": 0.300048828125}, {"start": 2253.36, "end": 2254.28, "word": " Okay.", "probability": 0.8818359375}, {"start": 2256.72, "end": 2257.64, "word": " So", "probability": 0.95166015625}], "temperature": 1.0}, {"id": 82, "seek": 229065, "start": 2262.35, "end": 2290.65, "text": " It is longer than the nominative case or the damma in Arabic. We have also the Arabic long vowel as in قابلة قابلة Okay, you have long vowel. Okay, it differs from what is longer than the accusative case fatha in Arabic. Still, we have in English the", "tokens": [467, 307, 2854, 813, 264, 5369, 259, 1166, 1389, 420, 264, 2422, 1696, 294, 19938, 13, 492, 362, 611, 264, 19938, 938, 29410, 382, 294, 12174, 16758, 37977, 12174, 16758, 37977, 1033, 11, 291, 362, 938, 29410, 13, 1033, 11, 309, 37761, 490, 437, 307, 2854, 813, 264, 11168, 1166, 1389, 283, 29441, 294, 19938, 13, 8291, 11, 321, 362, 294, 3669, 264], "avg_logprob": -0.2929687472060323, "compression_ratio": 1.572289156626506, "no_speech_prob": 0.0, "words": [{"start": 2262.35, "end": 2262.61, "word": " It", "probability": 0.413818359375}, {"start": 2262.61, "end": 2262.95, "word": " is", "probability": 0.9345703125}, {"start": 2262.95, "end": 2263.45, "word": " longer", "probability": 0.92626953125}, {"start": 2263.45, "end": 2263.93, "word": " than", "probability": 0.95166015625}, {"start": 2263.93, "end": 2264.81, "word": " the", "probability": 0.87255859375}, {"start": 2264.81, "end": 2265.25, "word": " nominative", "probability": 0.8811848958333334}, {"start": 2265.25, "end": 2265.71, "word": " case", "probability": 0.9306640625}, {"start": 2265.71, "end": 2265.97, "word": " or", "probability": 0.80126953125}, {"start": 2265.97, "end": 2266.25, "word": " the", "probability": 0.876953125}, {"start": 2266.25, "end": 2266.71, "word": " damma", "probability": 0.37847900390625}, {"start": 2266.71, "end": 2267.57, "word": " in", "probability": 0.86669921875}, {"start": 2267.57, "end": 2267.91, "word": " Arabic.", "probability": 0.90771484375}, {"start": 2268.29, "end": 2269.11, "word": " We", "probability": 0.9599609375}, {"start": 2269.11, "end": 2269.41, "word": " have", "probability": 0.93896484375}, {"start": 2269.41, "end": 2269.89, "word": " also", "probability": 0.8662109375}, {"start": 2269.89, "end": 2270.13, "word": " the", "probability": 0.91796875}, {"start": 2270.13, "end": 2270.49, "word": " Arabic", "probability": 0.90185546875}, {"start": 2270.49, "end": 2270.95, "word": " long", "probability": 0.9287109375}, {"start": 2270.95, "end": 2271.37, "word": " vowel", "probability": 0.97705078125}, {"start": 2271.37, "end": 2272.37, "word": " as", "probability": 0.2259521484375}, {"start": 2272.37, "end": 2273.95, "word": " in", "probability": 0.92333984375}, {"start": 2273.95, "end": 2275.15, "word": " قابلة", "probability": 0.7239583333333334}, {"start": 2275.15, "end": 2277.63, "word": " قابلة", "probability": 0.7450358072916666}, {"start": 2277.63, "end": 2278.93, "word": " Okay,", "probability": 0.410400390625}, {"start": 2278.97, "end": 2279.07, "word": " you", "probability": 0.67724609375}, {"start": 2279.07, "end": 2279.35, "word": " have", "probability": 0.9365234375}, {"start": 2279.35, "end": 2280.13, "word": " long", "probability": 0.86572265625}, {"start": 2280.13, "end": 2280.45, "word": " vowel.", "probability": 0.962890625}, {"start": 2281.27, "end": 2281.49, "word": " Okay,", "probability": 0.79296875}, {"start": 2281.83, "end": 2282.01, "word": " it", "probability": 0.94287109375}, {"start": 2282.01, "end": 2282.27, "word": " differs", "probability": 0.93359375}, {"start": 2282.27, "end": 2282.73, "word": " from", "probability": 0.8935546875}, {"start": 2282.73, "end": 2283.31, "word": " what", "probability": 0.83740234375}, {"start": 2283.31, "end": 2283.51, "word": " is", "probability": 0.94775390625}, {"start": 2283.51, "end": 2283.91, "word": " longer", "probability": 0.93359375}, {"start": 2283.91, "end": 2284.35, "word": " than", "probability": 0.9521484375}, {"start": 2284.35, "end": 2285.09, "word": " the", "probability": 0.90576171875}, {"start": 2285.09, "end": 2285.63, "word": " accusative", "probability": 0.9677734375}, {"start": 2285.63, "end": 2286.09, "word": " case", "probability": 0.94677734375}, {"start": 2286.09, "end": 2286.45, "word": " fatha", "probability": 0.5146484375}, {"start": 2286.45, "end": 2286.75, "word": " in", "probability": 0.93310546875}, {"start": 2286.75, "end": 2287.11, "word": " Arabic.", "probability": 0.92333984375}, {"start": 2288.09, "end": 2288.63, "word": " Still,", "probability": 0.82958984375}, {"start": 2288.69, "end": 2288.79, "word": " we", "probability": 0.95849609375}, {"start": 2288.79, "end": 2288.97, "word": " have", "probability": 0.94873046875}, {"start": 2288.97, "end": 2289.11, "word": " in", "probability": 0.93310546875}, {"start": 2289.11, "end": 2289.49, "word": " English", "probability": 0.9755859375}, {"start": 2289.49, "end": 2290.65, "word": " the", "probability": 0.470703125}], "temperature": 1.0}, {"id": 83, "seek": 232075, "start": 2292.11, "end": 2320.75, "text": " The A, sorry, the A sound which is long as in word, shirt, serve. Okay. We have also the O sound as in boat, law, all. So we don't say all. If you say all, this means that you insert the Arabic Hamza.", "tokens": [440, 316, 11, 2597, 11, 264, 316, 1626, 597, 307, 938, 382, 294, 1349, 11, 8336, 11, 4596, 13, 1033, 13, 492, 362, 611, 264, 422, 1626, 382, 294, 6582, 11, 2101, 11, 439, 13, 407, 321, 500, 380, 584, 439, 13, 759, 291, 584, 439, 11, 341, 1355, 300, 291, 8969, 264, 19938, 8234, 2394, 13], "avg_logprob": -0.18857758440848055, "compression_ratio": 1.3958333333333333, "no_speech_prob": 0.0, "words": [{"start": 2292.11, "end": 2292.39, "word": " The", "probability": 0.5048828125}, {"start": 2292.39, "end": 2292.77, "word": " A,", "probability": 0.372802734375}, {"start": 2293.15, "end": 2293.53, "word": " sorry,", "probability": 0.8681640625}, {"start": 2294.03, "end": 2294.15, "word": " the", "probability": 0.91796875}, {"start": 2294.15, "end": 2294.45, "word": " A", "probability": 0.7275390625}, {"start": 2294.45, "end": 2296.21, "word": " sound", "probability": 0.8564453125}, {"start": 2296.21, "end": 2296.59, "word": " which", "probability": 0.428955078125}, {"start": 2296.59, "end": 2296.79, "word": " is", "probability": 0.95263671875}, {"start": 2296.79, "end": 2297.19, "word": " long", "probability": 0.94677734375}, {"start": 2297.19, "end": 2297.53, "word": " as", "probability": 0.6650390625}, {"start": 2297.53, "end": 2298.41, "word": " in", "probability": 0.9453125}, {"start": 2298.41, "end": 2299.29, "word": " word,", "probability": 0.8388671875}, {"start": 2300.57, "end": 2301.21, "word": " shirt,", "probability": 0.82861328125}, {"start": 2302.59, "end": 2303.21, "word": " serve.", "probability": 0.8828125}, {"start": 2304.61, "end": 2305.33, "word": " Okay.", "probability": 0.7978515625}, {"start": 2305.91, "end": 2306.29, "word": " We", "probability": 0.96435546875}, {"start": 2306.29, "end": 2306.59, "word": " have", "probability": 0.94970703125}, {"start": 2306.59, "end": 2308.13, "word": " also", "probability": 0.86328125}, {"start": 2308.13, "end": 2309.01, "word": " the", "probability": 0.90966796875}, {"start": 2309.01, "end": 2309.41, "word": " O", "probability": 0.91552734375}, {"start": 2309.41, "end": 2310.11, "word": " sound", "probability": 0.927734375}, {"start": 2310.11, "end": 2311.39, "word": " as", "probability": 0.85595703125}, {"start": 2311.39, "end": 2311.81, "word": " in", "probability": 0.94775390625}, {"start": 2311.81, "end": 2312.45, "word": " boat,", "probability": 0.9287109375}, {"start": 2313.53, "end": 2313.93, "word": " law,", "probability": 0.61767578125}, {"start": 2314.81, "end": 2315.33, "word": " all.", "probability": 0.8662109375}, {"start": 2315.73, "end": 2316.21, "word": " So", "probability": 0.95166015625}, {"start": 2316.21, "end": 2316.35, "word": " we", "probability": 0.619140625}, {"start": 2316.35, "end": 2316.49, "word": " don't", "probability": 0.97314453125}, {"start": 2316.49, "end": 2316.75, "word": " say", "probability": 0.95458984375}, {"start": 2316.75, "end": 2317.29, "word": " all.", "probability": 0.63330078125}, {"start": 2317.59, "end": 2317.95, "word": " If", "probability": 0.9677734375}, {"start": 2317.95, "end": 2318.07, "word": " you", "probability": 0.96337890625}, {"start": 2318.07, "end": 2318.27, "word": " say", "probability": 0.94677734375}, {"start": 2318.27, "end": 2318.61, "word": " all,", "probability": 0.916015625}, {"start": 2318.69, "end": 2318.81, "word": " this", "probability": 0.92431640625}, {"start": 2318.81, "end": 2319.05, "word": " means", "probability": 0.93408203125}, {"start": 2319.05, "end": 2319.31, "word": " that", "probability": 0.91552734375}, {"start": 2319.31, "end": 2319.47, "word": " you", "probability": 0.96728515625}, {"start": 2319.47, "end": 2319.83, "word": " insert", "probability": 0.86572265625}, {"start": 2319.83, "end": 2320.01, "word": " the", "probability": 0.91015625}, {"start": 2320.01, "end": 2320.33, "word": " Arabic", "probability": 0.9072265625}, {"start": 2320.33, "end": 2320.75, "word": " Hamza.", "probability": 0.83935546875}], "temperature": 1.0}, {"id": 84, "seek": 234471, "start": 2321.32, "end": 2344.72, "text": " It is all, okay? So this is, or these are areas of difficulties, as you see, resulting from the difference between the sound system of English and the sound system of Arabic, okay? We have a as in, sorry. We have a, a as in Clark, fa, pat.", "tokens": [467, 307, 439, 11, 1392, 30, 407, 341, 307, 11, 420, 613, 366, 3179, 295, 14399, 11, 382, 291, 536, 11, 16505, 490, 264, 2649, 1296, 264, 1626, 1185, 295, 3669, 293, 264, 1626, 1185, 295, 19938, 11, 1392, 30, 492, 362, 257, 382, 294, 11, 2597, 13, 492, 362, 257, 11, 257, 382, 294, 18572, 11, 2050, 11, 1947, 13], "avg_logprob": -0.26411291091672834, "compression_ratio": 1.5286624203821657, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2321.32, "end": 2321.56, "word": " It", "probability": 0.6669921875}, {"start": 2321.56, "end": 2321.78, "word": " is", "probability": 0.92578125}, {"start": 2321.78, "end": 2322.3, "word": " all,", "probability": 0.77490234375}, {"start": 2322.68, "end": 2323.24, "word": " okay?", "probability": 0.798828125}, {"start": 2323.66, "end": 2323.98, "word": " So", "probability": 0.865234375}, {"start": 2323.98, "end": 2324.22, "word": " this", "probability": 0.446533203125}, {"start": 2324.22, "end": 2324.46, "word": " is,", "probability": 0.9296875}, {"start": 2324.6, "end": 2324.72, "word": " or", "probability": 0.61328125}, {"start": 2324.72, "end": 2324.98, "word": " these", "probability": 0.85205078125}, {"start": 2324.98, "end": 2325.26, "word": " are", "probability": 0.93798828125}, {"start": 2325.26, "end": 2325.76, "word": " areas", "probability": 0.91552734375}, {"start": 2325.76, "end": 2326.22, "word": " of", "probability": 0.96875}, {"start": 2326.22, "end": 2327.54, "word": " difficulties,", "probability": 0.8818359375}, {"start": 2327.74, "end": 2327.94, "word": " as", "probability": 0.9580078125}, {"start": 2327.94, "end": 2328.08, "word": " you", "probability": 0.96923828125}, {"start": 2328.08, "end": 2328.26, "word": " see,", "probability": 0.93359375}, {"start": 2328.38, "end": 2328.7, "word": " resulting", "probability": 0.97509765625}, {"start": 2328.7, "end": 2329.22, "word": " from", "probability": 0.892578125}, {"start": 2329.22, "end": 2330.22, "word": " the", "probability": 0.92431640625}, {"start": 2330.22, "end": 2332.1, "word": " difference", "probability": 0.85595703125}, {"start": 2332.1, "end": 2332.4, "word": " between", "probability": 0.8896484375}, {"start": 2332.4, "end": 2332.62, "word": " the", "probability": 0.9287109375}, {"start": 2332.62, "end": 2332.84, "word": " sound", "probability": 0.90478515625}, {"start": 2332.84, "end": 2333.22, "word": " system", "probability": 0.95458984375}, {"start": 2333.22, "end": 2333.4, "word": " of", "probability": 0.97119140625}, {"start": 2333.4, "end": 2333.7, "word": " English", "probability": 0.9794921875}, {"start": 2333.7, "end": 2333.96, "word": " and", "probability": 0.90087890625}, {"start": 2333.96, "end": 2334.1, "word": " the", "probability": 0.923828125}, {"start": 2334.1, "end": 2334.3, "word": " sound", "probability": 0.88671875}, {"start": 2334.3, "end": 2334.8, "word": " system", "probability": 0.95263671875}, {"start": 2334.8, "end": 2335.1, "word": " of", "probability": 0.9736328125}, {"start": 2335.1, "end": 2335.44, "word": " Arabic,", "probability": 0.90478515625}, {"start": 2336.02, "end": 2336.38, "word": " okay?", "probability": 0.9140625}, {"start": 2337.16, "end": 2337.44, "word": " We", "probability": 0.95166015625}, {"start": 2337.44, "end": 2337.66, "word": " have", "probability": 0.94921875}, {"start": 2337.66, "end": 2338.0, "word": " a", "probability": 0.29296875}, {"start": 2338.0, "end": 2338.6, "word": " as", "probability": 0.7646484375}, {"start": 2338.6, "end": 2338.88, "word": " in,", "probability": 0.9453125}, {"start": 2339.1, "end": 2339.62, "word": " sorry.", "probability": 0.77490234375}, {"start": 2340.0, "end": 2340.18, "word": " We", "probability": 0.9541015625}, {"start": 2340.18, "end": 2340.4, "word": " have", "probability": 0.9501953125}, {"start": 2340.4, "end": 2340.72, "word": " a,", "probability": 0.8984375}, {"start": 2341.14, "end": 2341.46, "word": " a", "probability": 0.7734375}, {"start": 2341.46, "end": 2341.86, "word": " as", "probability": 0.73779296875}, {"start": 2341.86, "end": 2342.06, "word": " in", "probability": 0.955078125}, {"start": 2342.06, "end": 2342.62, "word": " Clark,", "probability": 0.765625}, {"start": 2343.28, "end": 2343.64, "word": " fa,", "probability": 0.8232421875}, {"start": 2344.3, "end": 2344.72, "word": " pat.", "probability": 0.37158203125}], "temperature": 1.0}, {"id": 85, "seek": 236794, "start": 2346.18, "end": 2367.94, "text": " Okay? Another long vowel of English, which is not found in Arabic as well. Fine. Now, we finish the sound system or mean the consonants.", "tokens": [1033, 30, 3996, 938, 29410, 295, 3669, 11, 597, 307, 406, 1352, 294, 19938, 382, 731, 13, 12024, 13, 823, 11, 321, 2413, 264, 1626, 1185, 420, 914, 264, 30843, 1719, 13], "avg_logprob": -0.18383049242424243, "compression_ratio": 1.2123893805309736, "no_speech_prob": 0.0, "words": [{"start": 2346.1800000000003, "end": 2346.86, "word": " Okay?", "probability": 0.445556640625}, {"start": 2347.52, "end": 2348.14, "word": " Another", "probability": 0.84423828125}, {"start": 2348.14, "end": 2348.76, "word": " long", "probability": 0.919921875}, {"start": 2348.76, "end": 2349.1, "word": " vowel", "probability": 0.9794921875}, {"start": 2349.1, "end": 2349.34, "word": " of", "probability": 0.974609375}, {"start": 2349.34, "end": 2349.76, "word": " English,", "probability": 0.97607421875}, {"start": 2350.14, "end": 2350.3, "word": " which", "probability": 0.94580078125}, {"start": 2350.3, "end": 2350.44, "word": " is", "probability": 0.943359375}, {"start": 2350.44, "end": 2350.58, "word": " not", "probability": 0.951171875}, {"start": 2350.58, "end": 2350.92, "word": " found", "probability": 0.904296875}, {"start": 2350.92, "end": 2351.08, "word": " in", "probability": 0.95068359375}, {"start": 2351.08, "end": 2351.34, "word": " Arabic", "probability": 0.93017578125}, {"start": 2351.34, "end": 2351.62, "word": " as", "probability": 0.92724609375}, {"start": 2351.62, "end": 2351.8, "word": " well.", "probability": 0.94921875}, {"start": 2356.22, "end": 2356.9, "word": " Fine.", "probability": 0.92041015625}, {"start": 2362.98, "end": 2363.66, "word": " Now,", "probability": 0.95068359375}, {"start": 2364.64, "end": 2364.92, "word": " we", "probability": 0.95556640625}, {"start": 2364.92, "end": 2365.22, "word": " finish", "probability": 0.7705078125}, {"start": 2365.22, "end": 2365.42, "word": " the", "probability": 0.921875}, {"start": 2365.42, "end": 2365.64, "word": " sound", "probability": 0.90576171875}, {"start": 2365.64, "end": 2366.1, "word": " system", "probability": 0.94921875}, {"start": 2366.1, "end": 2366.36, "word": " or", "probability": 0.55908203125}, {"start": 2366.36, "end": 2366.54, "word": " mean", "probability": 0.373291015625}, {"start": 2366.54, "end": 2367.16, "word": " the", "probability": 0.85693359375}, {"start": 2367.16, "end": 2367.94, "word": " consonants.", "probability": 0.956298828125}], "temperature": 1.0}, {"id": 86, "seek": 239896, "start": 2371.27, "end": 2398.97, "text": " and the vowels of English, but still we have the diphthongs, which are also problematic. So, let's see a summary of what we have said. We've seen that English has nearly seven short vowels, five long vowels, and still we have diphthongs nearly 13,", "tokens": [293, 264, 44972, 295, 3669, 11, 457, 920, 321, 362, 264, 10460, 357, 71, 42478, 11, 597, 366, 611, 19011, 13, 407, 11, 718, 311, 536, 257, 12691, 295, 437, 321, 362, 848, 13, 492, 600, 1612, 300, 3669, 575, 6217, 3407, 2099, 44972, 11, 1732, 938, 44972, 11, 293, 920, 321, 362, 10460, 357, 71, 42478, 6217, 3705, 11], "avg_logprob": -0.14062499413724805, "compression_ratio": 1.5403726708074534, "no_speech_prob": 0.0, "words": [{"start": 2371.27, "end": 2371.63, "word": " and", "probability": 0.56201171875}, {"start": 2371.63, "end": 2371.77, "word": " the", "probability": 0.6904296875}, {"start": 2371.77, "end": 2372.15, "word": " vowels", "probability": 0.9794921875}, {"start": 2372.15, "end": 2373.37, "word": " of", "probability": 0.9619140625}, {"start": 2373.37, "end": 2373.71, "word": " English,", "probability": 0.9794921875}, {"start": 2373.83, "end": 2373.93, "word": " but", "probability": 0.92822265625}, {"start": 2373.93, "end": 2374.23, "word": " still", "probability": 0.935546875}, {"start": 2374.23, "end": 2374.43, "word": " we", "probability": 0.732421875}, {"start": 2374.43, "end": 2374.79, "word": " have", "probability": 0.94970703125}, {"start": 2374.79, "end": 2375.75, "word": " the", "probability": 0.8671875}, {"start": 2375.75, "end": 2376.37, "word": " diphthongs,", "probability": 0.9110107421875}, {"start": 2377.39, "end": 2377.89, "word": " which", "probability": 0.94677734375}, {"start": 2377.89, "end": 2378.17, "word": " are", "probability": 0.93798828125}, {"start": 2378.17, "end": 2378.57, "word": " also", "probability": 0.87939453125}, {"start": 2378.57, "end": 2379.05, "word": " problematic.", "probability": 0.79052734375}, {"start": 2380.55, "end": 2380.87, "word": " So,", "probability": 0.8515625}, {"start": 2381.67, "end": 2383.35, "word": " let's", "probability": 0.966552734375}, {"start": 2383.35, "end": 2383.61, "word": " see", "probability": 0.93115234375}, {"start": 2383.61, "end": 2385.53, "word": " a", "probability": 0.94580078125}, {"start": 2385.53, "end": 2385.81, "word": " summary", "probability": 0.90087890625}, {"start": 2385.81, "end": 2386.05, "word": " of", "probability": 0.96875}, {"start": 2386.05, "end": 2386.19, "word": " what", "probability": 0.947265625}, {"start": 2386.19, "end": 2386.35, "word": " we", "probability": 0.96337890625}, {"start": 2386.35, "end": 2386.53, "word": " have", "probability": 0.9345703125}, {"start": 2386.53, "end": 2386.81, "word": " said.", "probability": 0.94775390625}, {"start": 2387.77, "end": 2388.35, "word": " We've", "probability": 0.9150390625}, {"start": 2388.35, "end": 2388.59, "word": " seen", "probability": 0.95947265625}, {"start": 2388.59, "end": 2388.91, "word": " that", "probability": 0.935546875}, {"start": 2388.91, "end": 2389.39, "word": " English", "probability": 0.97412109375}, {"start": 2389.39, "end": 2390.61, "word": " has", "probability": 0.94384765625}, {"start": 2390.61, "end": 2391.01, "word": " nearly", "probability": 0.88525390625}, {"start": 2391.01, "end": 2391.55, "word": " seven", "probability": 0.8544921875}, {"start": 2391.55, "end": 2392.23, "word": " short", "probability": 0.958984375}, {"start": 2392.23, "end": 2392.67, "word": " vowels,", "probability": 0.9873046875}, {"start": 2393.63, "end": 2393.97, "word": " five", "probability": 0.9072265625}, {"start": 2393.97, "end": 2394.39, "word": " long", "probability": 0.92822265625}, {"start": 2394.39, "end": 2394.87, "word": " vowels,", "probability": 0.98876953125}, {"start": 2395.53, "end": 2395.87, "word": " and", "probability": 0.9423828125}, {"start": 2395.87, "end": 2396.25, "word": " still", "probability": 0.935546875}, {"start": 2396.25, "end": 2397.11, "word": " we", "probability": 0.732421875}, {"start": 2397.11, "end": 2397.43, "word": " have", "probability": 0.9453125}, {"start": 2397.43, "end": 2397.99, "word": " diphthongs", "probability": 0.8944091796875}, {"start": 2397.99, "end": 2398.39, "word": " nearly", "probability": 0.798828125}, {"start": 2398.39, "end": 2398.97, "word": " 13,", "probability": 0.6796875}], "temperature": 1.0}, {"id": 87, "seek": 242482, "start": 2400.38, "end": 2424.82, "text": " And diphthongs as well. In Arabic, we have only two diphthongs. However, in English, we have a number of diphthongs. This means that they all are very, very peculiar to Arab native speakers of English.", "tokens": [400, 10460, 357, 71, 42478, 382, 731, 13, 682, 19938, 11, 321, 362, 787, 732, 10460, 357, 71, 42478, 13, 2908, 11, 294, 3669, 11, 321, 362, 257, 1230, 295, 10460, 357, 71, 42478, 13, 639, 1355, 300, 436, 439, 366, 588, 11, 588, 27149, 281, 8625, 8470, 9518, 295, 3669, 13], "avg_logprob": -0.14349940587889473, "compression_ratio": 1.4428571428571428, "no_speech_prob": 0.0, "words": [{"start": 2400.38, "end": 2400.82, "word": " And", "probability": 0.50537109375}, {"start": 2400.82, "end": 2401.26, "word": " diphthongs", "probability": 0.829833984375}, {"start": 2401.26, "end": 2402.16, "word": " as", "probability": 0.8369140625}, {"start": 2402.16, "end": 2402.42, "word": " well.", "probability": 0.94775390625}, {"start": 2404.14, "end": 2404.44, "word": " In", "probability": 0.97314453125}, {"start": 2404.44, "end": 2404.78, "word": " Arabic,", "probability": 0.91259765625}, {"start": 2405.16, "end": 2405.28, "word": " we", "probability": 0.96337890625}, {"start": 2405.28, "end": 2405.48, "word": " have", "probability": 0.92578125}, {"start": 2405.48, "end": 2405.82, "word": " only", "probability": 0.9228515625}, {"start": 2405.82, "end": 2406.26, "word": " two", "probability": 0.92578125}, {"start": 2406.26, "end": 2407.22, "word": " diphthongs.", "probability": 0.9072265625}, {"start": 2410.18, "end": 2410.94, "word": " However,", "probability": 0.384765625}, {"start": 2413.14, "end": 2413.34, "word": " in", "probability": 0.955078125}, {"start": 2413.34, "end": 2413.68, "word": " English,", "probability": 0.9775390625}, {"start": 2414.18, "end": 2414.46, "word": " we", "probability": 0.962890625}, {"start": 2414.46, "end": 2414.6, "word": " have", "probability": 0.94921875}, {"start": 2414.6, "end": 2414.7, "word": " a", "probability": 0.9931640625}, {"start": 2414.7, "end": 2415.0, "word": " number", "probability": 0.9296875}, {"start": 2415.0, "end": 2415.52, "word": " of", "probability": 0.96875}, {"start": 2415.52, "end": 2416.16, "word": " diphthongs.", "probability": 0.92529296875}, {"start": 2416.7, "end": 2416.88, "word": " This", "probability": 0.8994140625}, {"start": 2416.88, "end": 2417.22, "word": " means", "probability": 0.92919921875}, {"start": 2417.22, "end": 2417.56, "word": " that", "probability": 0.91796875}, {"start": 2417.56, "end": 2417.74, "word": " they", "probability": 0.88720703125}, {"start": 2417.74, "end": 2418.18, "word": " all", "probability": 0.8486328125}, {"start": 2418.18, "end": 2420.24, "word": " are", "probability": 0.93359375}, {"start": 2420.24, "end": 2420.62, "word": " very,", "probability": 0.86376953125}, {"start": 2420.68, "end": 2420.9, "word": " very", "probability": 0.85693359375}, {"start": 2420.9, "end": 2421.48, "word": " peculiar", "probability": 0.95166015625}, {"start": 2421.48, "end": 2422.8, "word": " to", "probability": 0.923828125}, {"start": 2422.8, "end": 2423.4, "word": " Arab", "probability": 0.6689453125}, {"start": 2423.4, "end": 2423.8, "word": " native", "probability": 0.75634765625}, {"start": 2423.8, "end": 2424.24, "word": " speakers", "probability": 0.87890625}, {"start": 2424.24, "end": 2424.46, "word": " of", "probability": 0.9716796875}, {"start": 2424.46, "end": 2424.82, "word": " English.", "probability": 0.9775390625}], "temperature": 1.0}, {"id": 88, "seek": 245115, "start": 2426.51, "end": 2451.15, "text": " This means that we expect them to commit serious mistakes in pronouncing these diphthongs as they normally do with the long vowels and the short vowels. Because you know the system here is different from Arabic. Mainly because the two languages, as mentioned, are derived from different roots.", "tokens": [639, 1355, 300, 321, 2066, 552, 281, 5599, 3156, 8038, 294, 14144, 2175, 613, 10460, 357, 71, 42478, 382, 436, 5646, 360, 365, 264, 938, 44972, 293, 264, 2099, 44972, 13, 1436, 291, 458, 264, 1185, 510, 307, 819, 490, 19938, 13, 47468, 570, 264, 732, 8650, 11, 382, 2835, 11, 366, 18949, 490, 819, 10669, 13], "avg_logprob": -0.16446659713983536, "compression_ratio": 1.5154639175257731, "no_speech_prob": 0.0, "words": [{"start": 2426.51, "end": 2426.79, "word": " This", "probability": 0.7470703125}, {"start": 2426.79, "end": 2427.05, "word": " means", "probability": 0.93798828125}, {"start": 2427.05, "end": 2427.33, "word": " that", "probability": 0.89111328125}, {"start": 2427.33, "end": 2427.49, "word": " we", "probability": 0.95166015625}, {"start": 2427.49, "end": 2427.97, "word": " expect", "probability": 0.931640625}, {"start": 2427.97, "end": 2428.27, "word": " them", "probability": 0.91015625}, {"start": 2428.27, "end": 2428.45, "word": " to", "probability": 0.97607421875}, {"start": 2428.45, "end": 2428.89, "word": " commit", "probability": 0.75927734375}, {"start": 2428.89, "end": 2430.09, "word": " serious", "probability": 0.90087890625}, {"start": 2430.09, "end": 2430.69, "word": " mistakes", "probability": 0.8837890625}, {"start": 2430.69, "end": 2430.99, "word": " in", "probability": 0.7587890625}, {"start": 2430.99, "end": 2432.15, "word": " pronouncing", "probability": 0.963623046875}, {"start": 2432.15, "end": 2432.81, "word": " these", "probability": 0.875}, {"start": 2432.81, "end": 2434.11, "word": " diphthongs", "probability": 0.864013671875}, {"start": 2434.11, "end": 2435.37, "word": " as", "probability": 0.5400390625}, {"start": 2435.37, "end": 2435.69, "word": " they", "probability": 0.89990234375}, {"start": 2435.69, "end": 2436.59, "word": " normally", "probability": 0.89404296875}, {"start": 2436.59, "end": 2436.93, "word": " do", 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"probability": 0.640625}, {"start": 2441.09, "end": 2441.53, "word": " system", "probability": 0.95263671875}, {"start": 2441.53, "end": 2443.13, "word": " here", "probability": 0.8330078125}, {"start": 2443.13, "end": 2443.85, "word": " is", "probability": 0.9423828125}, {"start": 2443.85, "end": 2444.23, "word": " different", "probability": 0.8896484375}, {"start": 2444.23, "end": 2444.49, "word": " from", "probability": 0.88037109375}, {"start": 2444.49, "end": 2444.97, "word": " Arabic.", "probability": 0.93115234375}, {"start": 2445.57, "end": 2445.91, "word": " Mainly", "probability": 0.857421875}, {"start": 2445.91, "end": 2446.29, "word": " because", "probability": 0.87841796875}, {"start": 2446.29, "end": 2446.45, "word": " the", "probability": 0.91796875}, {"start": 2446.45, "end": 2446.63, "word": " two", "probability": 0.93408203125}, {"start": 2446.63, "end": 2447.03, "word": " languages,", "probability": 0.9619140625}, {"start": 2447.33, "end": 2447.43, "word": " as", "probability": 0.96630859375}, {"start": 2447.43, "end": 2447.87, "word": " mentioned,", "probability": 0.81005859375}, {"start": 2448.79, "end": 2449.15, "word": " are", "probability": 0.93701171875}, {"start": 2449.15, "end": 2449.81, "word": " derived", "probability": 0.8291015625}, {"start": 2449.81, "end": 2450.19, "word": " from", "probability": 0.8837890625}, {"start": 2450.19, "end": 2450.73, "word": " different", "probability": 0.8876953125}, {"start": 2450.73, "end": 2451.15, "word": " roots.", "probability": 0.91162109375}], "temperature": 1.0}, {"id": 89, "seek": 246765, "start": 2452.37, "end": 2467.65, "text": " English is Indo-European, Arabic is Semitic, so we cannot, I mean, if you see this, you can find the difficulty just in the number of mistakes committed by your students and maybe by yourselves.", "tokens": [3669, 307, 46489, 12, 32293, 282, 11, 19938, 307, 14421, 44592, 11, 370, 321, 2644, 11, 286, 914, 11, 498, 291, 536, 341, 11, 291, 393, 915, 264, 10360, 445, 294, 264, 1230, 295, 8038, 7784, 538, 428, 1731, 293, 1310, 538, 14791, 13], "avg_logprob": -0.18871528175142077, "compression_ratio": 1.3541666666666667, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 2452.37, "end": 2452.75, "word": " English", "probability": 0.9619140625}, {"start": 2452.75, "end": 2453.03, "word": " is", "probability": 0.9541015625}, {"start": 2453.03, "end": 2453.27, "word": " Indo", "probability": 0.87255859375}, {"start": 2453.27, "end": 2453.89, "word": "-European,", "probability": 0.9091796875}, {"start": 2454.49, "end": 2454.85, "word": " Arabic", "probability": 0.91015625}, {"start": 2454.85, "end": 2455.31, "word": " is", "probability": 0.955078125}, {"start": 2455.31, "end": 2455.93, "word": " Semitic,", "probability": 0.61181640625}, {"start": 2456.51, "end": 2456.69, "word": " so", "probability": 0.8076171875}, {"start": 2456.69, "end": 2457.09, "word": " we", "probability": 0.6552734375}, {"start": 2457.09, "end": 2457.43, "word": " cannot,", "probability": 0.87255859375}, {"start": 2457.61, "end": 2457.71, "word": " I", "probability": 0.8701171875}, {"start": 2457.71, "end": 2457.87, "word": " mean,", "probability": 0.962890625}, {"start": 2457.93, "end": 2458.11, "word": " if", "probability": 0.9599609375}, {"start": 2458.11, "end": 2458.27, "word": " you", "probability": 0.96630859375}, {"start": 2458.27, "end": 2458.45, "word": " see", "probability": 0.93017578125}, {"start": 2458.45, "end": 2458.75, "word": " this,", "probability": 0.947265625}, {"start": 2459.11, "end": 2459.21, "word": " you", "probability": 0.96484375}, {"start": 2459.21, "end": 2459.51, "word": " can", "probability": 0.93408203125}, {"start": 2459.51, "end": 2460.13, "word": " find", "probability": 0.78759765625}, {"start": 2460.13, "end": 2460.97, "word": " the", "probability": 0.90771484375}, {"start": 2460.97, "end": 2461.67, "word": " difficulty", "probability": 0.70361328125}, {"start": 2461.67, "end": 2462.17, "word": " just", "probability": 0.87744140625}, {"start": 2462.17, "end": 2462.35, "word": " in", "probability": 0.94873046875}, {"start": 2462.35, "end": 2462.47, "word": " the", "probability": 0.91650390625}, {"start": 2462.47, "end": 2462.83, "word": " number", "probability": 0.94189453125}, {"start": 2462.83, "end": 2463.21, "word": " of", "probability": 0.97509765625}, {"start": 2463.21, "end": 2463.69, "word": " mistakes", "probability": 0.90966796875}, {"start": 2463.69, "end": 2464.15, "word": " committed", "probability": 0.9443359375}, {"start": 2464.15, "end": 2464.43, "word": " by", "probability": 0.9677734375}, {"start": 2464.43, "end": 2464.65, "word": " your", "probability": 0.86767578125}, {"start": 2464.65, "end": 2465.11, "word": " students", "probability": 0.97607421875}, {"start": 2465.11, "end": 2466.05, "word": " and", "probability": 0.5654296875}, {"start": 2466.05, "end": 2466.39, "word": " maybe", "probability": 0.94140625}, {"start": 2466.39, "end": 2467.09, "word": " by", 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Once reading, once speaking, et cetera, you find this difficulty and you lots of times meet with Arabic pronunciation or Arabic features inserted in English. Okay? The schwach system is very difficult. 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So this is another area of difficulty. You have to be aware of that in order to pronounce English correctly. The doubling, or what is called the gemination system. The gemination system is available in Arabic, not English. So whenever you see two, I mean, double letters,", "tokens": [366, 2435, 294, 3669, 11, 457, 406, 294, 19938, 13, 407, 341, 307, 1071, 1859, 295, 10360, 13, 509, 362, 281, 312, 3650, 295, 300, 294, 1668, 281, 19567, 3669, 8944, 13, 440, 33651, 11, 420, 437, 307, 1219, 264, 7173, 2486, 1185, 13, 440, 7173, 2486, 1185, 307, 2435, 294, 19938, 11, 406, 3669, 13, 407, 5699, 291, 536, 732, 11, 286, 914, 11, 3834, 7825, 11], "avg_logprob": -0.20029438233030014, "compression_ratio": 1.601010101010101, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 2494.24, "end": 2494.52, "word": " are", "probability": 0.69140625}, {"start": 2494.52, "end": 2494.94, "word": " available", "probability": 0.83154296875}, {"start": 2494.94, "end": 2495.2, "word": " in", "probability": 0.9541015625}, {"start": 2495.2, "end": 2495.46, "word": " English,", "probability": 0.98095703125}, {"start": 2495.56, "end": 2495.66, "word": " but", "probability": 0.927734375}, {"start": 2495.66, "end": 2495.86, 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So, we don't say, for example, collapse. We say collapse. Comment, command, etc. Okay? The Hamza of Arabic sometimes is found in English wrongly by your students. 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So you have to be familiar with that and take care. And next time, inshallah, we are going to explain the difference and the rest of the sound in isolation. See you next time. Thank you now.", "tokens": [1726, 2435, 294, 19938, 11, 406, 2435, 294, 3669, 11, 570, 264, 787, 1563, 1521, 304, 1626, 294, 3669, 307, 264, 389, 1626, 13, 407, 291, 362, 281, 312, 4963, 365, 300, 293, 747, 1127, 13, 400, 958, 565, 11, 1028, 71, 13492, 11, 321, 366, 516, 281, 2903, 264, 2649, 293, 264, 1472, 295, 264, 1626, 294, 16001, 13, 3008, 291, 958, 565, 13, 1044, 291, 586, 13], "avg_logprob": -0.22879463604518346, "compression_ratio": 1.5873015873015872, "no_speech_prob": 1.150369644165039e-05, "words": [{"start": 2544.34, "end": 2544.62, "word": " Not", "probability": 0.5810546875}, {"start": 2544.62, "end": 2545.08, "word": " available", "probability": 0.83642578125}, {"start": 2545.08, "end": 2545.46, "word": " in", "probability": 0.9580078125}, {"start": 2545.46, "end": 2545.72, "word": " Arabic,", "probability": 0.931640625}, {"start": 2545.98, "end": 2546.36, "word": " not", "probability": 0.4443359375}, {"start": 2546.36, "end": 2547.18, "word": " available", 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/h-G8tDdYnps_postprocess.srt b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/h-G8tDdYnps_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..28dd7028fd589e23c5f21aa6fccfbb4d5c3bf8ea
--- /dev/null
+++ b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/h-G8tDdYnps_postprocess.srt
@@ -0,0 +1,1476 @@
+1
+00:00:13,720 --> 00:00:19,360
+today we are going to see infinitive and gerund in
+
+2
+00:00:19,360 --> 00:00:23,540
+English versus overt and covert derived nominal in
+
+3
+00:00:23,540 --> 00:00:30,260
+Arabic المصدر الصريح والمؤول in Arabic مقابل
+
+4
+00:00:30,260 --> 00:00:37,600
+infinitive and gerund in English The
+
+5
+00:00:37,600 --> 00:00:41,280
+infinitive construction as you know is non-finite
+
+6
+00:00:41,280 --> 00:00:47,820
+verb form Okay, it comprises two words two plus
+
+7
+00:00:47,820 --> 00:00:54,880
+the stem of the verb the stem of the verb Okay now
+
+8
+00:00:57,970 --> 00:01:04,150
+Syntactically, it serves as a subject or object or
+
+9
+00:01:04,150 --> 00:01:10,090
+a complement. So for example, to sign a truth now
+
+10
+00:01:10,090 --> 00:01:15,630
+seems very difficult. To sign a truth now seems
+
+11
+00:01:15,630 --> 00:01:20,290
+very difficult. To sign. Where's the subject of
+
+12
+00:01:20,290 --> 00:01:25,740
+the sentence? It is the infinitive. To sign it
+
+13
+00:01:25,740 --> 00:01:30,220
+seems very difficult to sign a truth now Again,
+
+14
+00:01:30,320 --> 00:01:34,400
+where is the subject it seems this is exemplative
+
+15
+00:01:34,400 --> 00:01:42,100
+verb Okay, it's not a subject To sign is again
+
+16
+00:01:42,100 --> 00:01:50,300
+subject of the sentence Here
+
+17
+00:01:50,300 --> 00:01:53,480
+in the previous sentence we have
+
+18
+00:01:56,400 --> 00:02:00,500
+It seems very difficult to sign a truth to sign as
+
+19
+00:02:00,500 --> 00:02:02,380
+a subject of the verb seem.
+
+20
+00:02:05,160 --> 00:02:13,960
+Okay. He wants to travel. He wants to travel. To
+
+21
+00:02:13,960 --> 00:02:20,140
+travel is an object. Okay. Object of the main
+
+22
+00:02:20,140 --> 00:02:24,780
+verb. Our hope is to make reconciliation between
+
+23
+00:02:24,780 --> 00:02:29,520
+the Palestinian presidency and government. Our
+
+24
+00:02:29,520 --> 00:02:33,340
+hope is to make. This is object.
+
+25
+00:02:36,380 --> 00:02:42,520
+Our hope is to make. To make here is subject
+
+26
+00:02:42,520 --> 00:02:46,180
+complement. Subject complement. We are going to
+
+27
+00:02:46,180 --> 00:02:50,750
+make. okay subject complement they elected him to
+
+28
+00:02:50,750 --> 00:02:55,610
+be the president the
+
+29
+00:02:55,610 --> 00:03:01,090
+infinitive here is object complement so the
+
+30
+00:03:01,090 --> 00:03:06,030
+infinitive can work as a subject as object as
+
+31
+00:03:06,030 --> 00:03:15,050
+subject complement or object complement okay do
+
+32
+00:03:15,050 --> 00:03:16,010
+we have this in Arabic?
+
+33
+00:03:22,660 --> 00:03:29,400
+Yes. Here we have the subject which can be a
+
+34
+00:03:29,400 --> 00:03:36,200
+modified derived nominal, but cannot be a modified
+
+35
+00:03:36,200 --> 00:03:40,200
+derived nominal, but it can be overt derived
+
+36
+00:03:40,200 --> 00:03:44,750
+nominal, masda sarih, but not modified derived
+
+37
+00:03:44,750 --> 00:03:58,290
+nominal it works
+
+38
+00:03:58,290 --> 00:04:03,730
+as a subject okay semantically it works as a
+
+39
+00:04:03,730 --> 00:04:10,990
+subject this
+
+40
+00:04:10,990 --> 00:04:20,470
+is not accepted and grammatical sentence okay
+
+41
+00:04:20,470 --> 00:04:24,910
+the
+
+42
+00:04:24,910 --> 00:04:30,830
+modified derived nominal can work as an object or
+
+43
+00:04:30,830 --> 00:04:36,590
+subject complement or object complement okay
+
+44
+00:04:45,470 --> 00:04:51,130
+You read Ali and Yusuf, this is object. Amaluna an
+
+45
+00:04:51,130 --> 00:04:57,090
+yakuna hunaka tawafuqun bayna Ali wa Ahmed Amaluna
+
+46
+00:04:57,090 --> 00:05:03,630
+an yakuna hunaka tawafuq Tawafuq is overt derived
+
+47
+00:05:03,630 --> 00:05:06,770
+nominal Okay
+
+48
+00:05:13,570 --> 00:05:21,170
+رشّحوه أن يكون رئيسا رشّحوه أن يكون رئيسا this is
+
+49
+00:05:21,170 --> 00:05:25,730
+object complement and the first sentence أملنا أن
+
+50
+00:05:25,730 --> 00:05:31,750
+يكون هناك توافق this is subject complement okay
+
+51
+00:05:31,750 --> 00:05:35,970
+here
+
+52
+00:05:35,970 --> 00:05:40,190
+we speak about infinitive the infinitive as you
+
+53
+00:05:40,190 --> 00:05:45,690
+see can work as a subject as object as subject
+
+54
+00:05:45,690 --> 00:05:50,030
+complement or object complement in English the
+
+55
+00:05:50,030 --> 00:05:53,250
+derived nominal in Arabic also can work as a
+
+56
+00:05:53,250 --> 00:05:57,250
+subject object subject complement or object
+
+57
+00:05:57,250 --> 00:06:04,550
+complement okay this is the syntactic function of
+
+58
+00:06:04,550 --> 00:06:10,470
+the infinitive now one
+
+59
+00:06:10,470 --> 00:06:12,750
+of the syntactic functions of the infinitive
+
+60
+00:06:13,510 --> 00:06:18,150
+appears in what is called sensation verbs. These
+
+61
+00:06:18,150 --> 00:06:22,670
+sensation verbs do not accept overt infinitive in
+
+62
+00:06:22,670 --> 00:06:26,970
+English. They only accept bare infinitive. Bare
+
+63
+00:06:26,970 --> 00:06:30,410
+infinitive. I heard them talk about the plan. I
+
+64
+00:06:30,410 --> 00:06:33,770
+cannot say I heard them to talk about the plan.
+
+65
+00:06:34,910 --> 00:06:41,400
+Talk about. We speak about sensation verbs. hear,
+
+66
+00:06:41,900 --> 00:06:48,100
+see, touch, notice, you know. I heard them to talk
+
+67
+00:06:48,100 --> 00:06:52,460
+about the plan is not accepted. I heard them talk
+
+68
+00:06:52,460 --> 00:06:58,440
+about the plan. I saw Ali stand at the gate. Stand
+
+69
+00:06:58,440 --> 00:07:03,220
+at the gate. Not to stand. I noticed here, pick a
+
+70
+00:07:03,220 --> 00:07:08,100
+flower. Notice here pick a flower Not to pick a
+
+71
+00:07:08,100 --> 00:07:12,620
+flower. So all sensation verbs except only bear
+
+72
+00:07:12,620 --> 00:07:17,880
+infinitive bear infinitive So you have to take
+
+73
+00:07:17,880 --> 00:07:23,480
+care of this So
+
+74
+00:07:23,480 --> 00:07:28,380
+by bear infinitive we mean the stem of the verb
+
+75
+00:07:28,380 --> 00:07:36,160
+okay? Yani verb without to okay it is the base of
+
+76
+00:07:36,160 --> 00:07:38,980
+the verb the first conjugation without having
+
+77
+00:07:38,980 --> 00:07:47,100
+inflections okay now do we have this in arabic do
+
+78
+00:07:47,100 --> 00:07:51,480
+you have equivalence to he noticed here pick a
+
+79
+00:07:51,480 --> 00:07:53,580
+flower okay
+
+80
+00:08:00,050 --> 00:08:05,030
+وردة تقطفوا يقطفوا أقطفوا نقطفوا نقطفوا is this
+
+81
+00:08:05,030 --> 00:08:08,890
+bear infinitive is this a verb this is a stem of
+
+82
+00:08:08,890 --> 00:08:14,050
+يعني this is a verb in its stem status we have the
+
+83
+00:08:14,050 --> 00:08:21,570
+inflection which are called persons in Arabic so
+
+84
+00:08:21,570 --> 00:08:24,990
+we have the verb inflicted in Arabic however in
+
+85
+00:08:24,990 --> 00:08:28,950
+English with infinitive with sensation verbs
+
+86
+00:08:28,950 --> 00:08:32,910
+there's no inflection there's nothing added to the
+
+87
+00:08:32,910 --> 00:08:38,630
+verb except its natural or its first status i mean
+
+88
+00:08:38,630 --> 00:08:43,510
+the stem status okay so this is called bare
+
+89
+00:08:43,510 --> 00:08:51,730
+infinitive bare infinitive سمعته يتكلم عن الخطة
+
+90
+00:08:51,730 --> 00:08:52,850
+يتكلم
+
+91
+00:08:55,610 --> 00:09:02,990
+The stem of Arabic يتكلم as a verb we have تكلم
+
+92
+00:09:02,990 --> 00:09:09,210
+without even inflections accusative or nominative
+
+93
+00:09:09,210 --> 00:09:19,810
+or genitive سمعته يتكلم عن الخطة رأيت محمدا يقف
+
+94
+00:09:19,810 --> 00:09:22,930
+عند البوابة يقف
+
+95
+00:09:26,840 --> 00:09:32,500
+لاحطتها تقطفو وردة تقطفو So we have as you see
+
+96
+00:09:32,500 --> 00:09:38,660
+gender appear very clearly for لاحطتها تقطفو وردة
+
+97
+00:09:38,660 --> 00:09:47,320
+محمد يقف we have the person ي ت and plus all
+
+98
+00:09:47,320 --> 00:09:51,650
+inflections added to the verb in the sentence in
+
+99
+00:09:51,650 --> 00:09:54,390
+Arabic however in English with sensation verbs
+
+100
+00:09:54,390 --> 00:09:58,690
+there is no overt infinitive يعني two plus verb we
+
+101
+00:09:58,690 --> 00:10:08,550
+only have the same none
+
+102
+00:10:08,550 --> 00:10:14,100
+so we have the verb دَع let يعني has the same
+
+103
+00:10:14,100 --> 00:10:19,000
+capacity as the sensation verb verb since it only
+
+104
+00:10:19,000 --> 00:10:24,400
+accepts the imperfect present indicative verb form
+
+105
+00:10:24,400 --> 00:10:30,860
+okay
+
+106
+00:10:30,860 --> 00:10:34,740
+we
+
+107
+00:10:34,740 --> 00:10:42,300
+can say so it takes only overt indicative overt
+
+108
+00:10:42,300 --> 00:10:46,860
+infinitive overt infinitive not modified
+
+109
+00:10:46,860 --> 00:10:51,660
+infinitive over derived nominal not modified
+
+110
+00:10:51,660 --> 00:10:56,940
+derived nominal okay we have also the inflection
+
+111
+00:10:56,940 --> 00:11:01,580
+okay
+
+112
+00:11:10,140 --> 00:11:19,740
+we have English sensation verb help they help him
+
+113
+00:11:19,740 --> 00:11:27,300
+solve the problem okay here
+
+114
+00:11:27,300 --> 00:11:31,180
+we have the English verb let along with the verb
+
+115
+00:11:31,180 --> 00:11:35,660
+help and make accept both bare infinitives and two
+
+116
+00:11:35,660 --> 00:11:41,250
+infinitives help let make they accept both bare
+
+117
+00:11:41,250 --> 00:11:45,850
+infinitive and to infinitive you have this these
+
+118
+00:11:45,850 --> 00:11:49,670
+are not sensation verbs these are not sensation
+
+119
+00:11:49,670 --> 00:11:58,050
+verbs so we have help let make they accept both to
+
+120
+00:11:58,050 --> 00:12:02,850
+infinitive and bare infinitive They helped him
+
+121
+00:12:02,850 --> 00:12:05,870
+solve the problem. Is it acceptable to say they
+
+122
+00:12:05,870 --> 00:12:09,830
+helped him to solve the problem? Yes. Okay.
+
+123
+00:12:12,050 --> 00:12:15,750
+However, this does not correspond to the Arabic
+
+124
+00:12:15,750 --> 00:12:18,210
+verb ساعدة.
+
+125
+00:12:19,910 --> 00:12:24,850
+ساعته حل المشكلة. Is that accepted in Arabic?
+
+126
+00:12:25,430 --> 00:12:31,230
+ساعته حل المشكلة. Okay. ساعته أن يحل المشكلة.
+
+127
+00:12:31,510 --> 00:12:35,490
+Again it is not accepted. We say in Arabic ساعته
+
+128
+00:12:35,490 --> 00:12:38,690
+على حل المشكلة and this is not infinitive. This is
+
+129
+00:12:38,690 --> 00:12:44,350
+not derived nominal. Okay. So it is not
+
+130
+00:12:44,350 --> 00:12:48,990
+necessarily to have equivalent verbs I mean,
+
+131
+00:12:49,390 --> 00:12:52,490
+syntactically or semantically between Arabic and
+
+132
+00:12:52,490 --> 00:12:56,290
+English. The verb help has its own characteristics
+
+133
+00:12:56,290 --> 00:13:01,610
+that differ from the verb Saada in Arabic. So
+
+134
+00:13:01,610 --> 00:13:05,110
+Saada has its own syntactic functions in Arabic
+
+135
+00:13:05,110 --> 00:13:08,230
+that differ completely from the verb help in
+
+136
+00:13:08,230 --> 00:13:11,790
+English. However, we have three verbs in English,
+
+137
+00:13:12,290 --> 00:13:17,520
+help, let, make. They accept both. bare infinitive
+
+138
+00:13:17,520 --> 00:13:21,560
+and too infinitive however the sensation verbs
+
+139
+00:13:21,560 --> 00:13:28,080
+only accept bare infinitive okay
+
+140
+00:13:28,080 --> 00:13:36,500
+now we speak about verbs accepting gerund or
+
+141
+00:13:36,500 --> 00:13:41,960
+infinitive in English you have some verbs accept
+
+142
+00:13:41,960 --> 00:13:47,590
+only infinitive Some other verbs accept gerund and
+
+143
+00:13:47,590 --> 00:13:52,070
+still we have verbs accept both infinitive and
+
+144
+00:13:52,070 --> 00:13:58,270
+gerund. Is there a certain rule that can govern
+
+145
+00:13:58,270 --> 00:14:05,610
+the construction of the infinitive or gerund in
+
+146
+00:14:05,610 --> 00:14:12,620
+English or not? We have some principles that can
+
+147
+00:14:12,620 --> 00:14:16,220
+distinguish between the use of infinitive or
+
+148
+00:14:16,220 --> 00:14:20,260
+gerund. One of them is called Bollinger principle.
+
+149
+00:14:22,100 --> 00:14:26,540
+Here we have the choice of infinitive or gerund
+
+150
+00:14:26,540 --> 00:14:30,300
+depends
+
+151
+00:14:30,300 --> 00:14:37,240
+on its semantic status. If the verb refers to
+
+152
+00:14:37,240 --> 00:14:42,200
+hypothetical future, unfulfilled future, not
+
+153
+00:14:42,200 --> 00:14:48,660
+achieved, then it is infinitive. If it is real, it
+
+154
+00:14:48,660 --> 00:14:52,520
+refers to real status, vivid or fulfilled, the
+
+155
+00:14:52,520 --> 00:14:55,880
+verb is fulfilled, then it is gerund. This is
+
+156
+00:14:55,880 --> 00:15:03,600
+according to Bollinger. Here we have this
+
+157
+00:15:03,600 --> 00:15:08,800
+violated in the following examples. It starts to
+
+158
+00:15:08,800 --> 00:15:13,240
+rain. It starts raining. How could you, is there
+
+159
+00:15:13,240 --> 00:15:15,260
+any difference in translation between the two
+
+160
+00:15:15,260 --> 00:15:22,460
+sentences? Is there any difference? It starts to
+
+161
+00:15:22,460 --> 00:15:27,180
+rain. It starts raining. I don't see any semantic
+
+162
+00:15:27,180 --> 00:15:30,640
+difference between the two sentences. So this
+
+163
+00:15:30,640 --> 00:15:34,800
+violates Bollinger's principle, which states that
+
+164
+00:15:34,800 --> 00:15:40,350
+the verbs with infinitive refer to hypothetical
+
+165
+00:15:40,350 --> 00:15:45,070
+actions, theoretical action, action which has not
+
+166
+00:15:45,070 --> 00:15:49,650
+happened yet, action which is to happen in future.
+
+167
+00:15:50,850 --> 00:15:54,810
+However, the gerund refers to an action that
+
+168
+00:15:54,810 --> 00:16:01,790
+happened, real action, fulfilled action. So we
+
+169
+00:16:01,790 --> 00:16:04,490
+have a problem here regarding this principle.
+
+170
+00:16:05,300 --> 00:16:09,440
+Richard continued to work. Richard continued
+
+171
+00:16:09,440 --> 00:16:15,140
+working. We have a problem in working here. Okay.
+
+172
+00:16:16,080 --> 00:16:20,340
+I prefer to eat sandwiches. I prefer eating
+
+173
+00:16:20,340 --> 00:16:26,100
+sandwiches. Is there any difference? Okay. So how
+
+174
+00:16:26,100 --> 00:16:29,960
+could we apply this rule on the verbs accepting
+
+175
+00:16:29,960 --> 00:16:33,320
+infinitive and gerund? We have both
+
+176
+00:16:35,940 --> 00:16:39,960
+ROK, I mean the infinitive and gerund can work
+
+177
+00:16:39,960 --> 00:16:43,720
+with the verb start and the verb refer and
+
+178
+00:16:43,720 --> 00:16:50,020
+continue. So we must find an alternative rule to
+
+179
+00:16:50,020 --> 00:16:54,900
+govern the status of infinitive and gerund in
+
+180
+00:16:54,900 --> 00:16:55,280
+English.
+
+181
+00:16:58,080 --> 00:17:06,900
+To solve this problem, I came with another rule. I
+
+182
+00:17:06,900 --> 00:17:11,000
+divided all verbs that accept infinitive and
+
+183
+00:17:11,000 --> 00:17:15,540
+gerund into four categories emotive verbs
+
+184
+00:17:15,540 --> 00:17:24,080
+aspectual verbs reactive verbs forward oriented
+
+185
+00:17:24,080 --> 00:17:28,700
+verbs semantically we divided all verbs that
+
+186
+00:17:28,700 --> 00:17:33,260
+accept gerund and infinitive into four categories
+
+187
+00:17:33,260 --> 00:17:39,650
+as you see let's see this new rule starting with
+
+188
+00:17:39,650 --> 00:17:45,550
+the first category emotive verbs okay
+
+189
+00:17:45,550 --> 00:17:48,650
+we
+
+190
+00:17:48,650 --> 00:17:55,830
+have quirk 1985 checker and winner 1994 plus amir
+
+191
+00:17:55,830 --> 00:17:57,350
+2004
+
+192
+00:18:05,140 --> 00:18:09,660
+Those researchers indicate that the mood and the
+
+193
+00:18:09,660 --> 00:18:12,000
+attitude of agents or participants,
+
+194
+00:18:15,120 --> 00:18:21,940
+I mean, the subject of the sentence and their
+
+195
+00:18:21,940 --> 00:18:26,960
+decide the infinitive or gerund.
+
+196
+00:18:30,660 --> 00:18:34,160
+Here, as I mentioned to you, we divided the verbs
+
+197
+00:18:34,160 --> 00:18:41,140
+into four categories. So the emotive verbs are
+
+198
+00:18:41,140 --> 00:18:45,880
+not associated with an explicit time reference in
+
+199
+00:18:45,880 --> 00:18:50,660
+meaning. They are not related to time. We speak
+
+200
+00:18:50,660 --> 00:18:53,660
+about emotions, like the verb
+
+201
+00:18:57,390 --> 00:19:03,790
+dread, hate, like, love, lose, prefer and rejoice.
+
+202
+00:19:06,890 --> 00:19:11,870
+These verbs are emotional verbs. They accept both
+
+203
+00:19:11,870 --> 00:19:16,570
+infinitive and gerund. So he hated to meet the
+
+204
+00:19:16,570 --> 00:19:19,410
+boss. He hated meeting the boss.
+
+205
+00:19:22,390 --> 00:19:25,050
+Is there any difference in meaning between the two
+
+206
+00:19:25,050 --> 00:19:31,070
+sentences? No, there is. There is difference in
+
+207
+00:19:31,070 --> 00:19:33,970
+translation. The first one, he hated to meet the
+
+208
+00:19:33,970 --> 00:19:38,590
+boss. This means that he has not yet met him.
+
+209
+00:19:39,190 --> 00:19:42,950
+Okay. However, he hated meeting the boss. This
+
+210
+00:19:42,950 --> 00:19:46,930
+means that he met him and he hated this meeting.
+
+211
+00:19:47,450 --> 00:19:51,550
+Okay. In something already done in the second
+
+212
+00:19:51,550 --> 00:19:54,350
+sentence. However, the first sentence is still
+
+213
+00:19:54,350 --> 00:20:00,120
+theoretical. an action to happen in future okay
+
+214
+00:20:00,120 --> 00:20:04,260
+would you like to see my dad you like seeing my
+
+215
+00:20:04,260 --> 00:20:08,620
+dad see
+
+216
+00:20:08,620 --> 00:20:15,440
+we have infinitive overt infinitive as you see and
+
+217
+00:20:15,440 --> 00:20:16,460
+then we have gerund
+
+218
+00:20:21,020 --> 00:20:25,680
+Ali Luth to participate in the debate. Ali Luth
+
+219
+00:20:25,680 --> 00:20:27,940
+participating in the debate. We have also
+
+220
+00:20:27,940 --> 00:20:32,400
+difference between the two sentences as done in
+
+221
+00:20:32,400 --> 00:20:35,600
+the first sentence. Do you prefer to read the
+
+222
+00:20:35,600 --> 00:20:38,260
+daily or to watch the TV news?
+
+223
+00:20:40,980 --> 00:20:43,840
+It's still theoretical. Do you prefer reading the
+
+224
+00:20:43,840 --> 00:20:49,780
+daily or watching the TV news? Now this is real.
+
+225
+00:20:50,440 --> 00:20:53,420
+Okay. So there is a big difference in translation
+
+226
+00:20:53,420 --> 00:20:56,960
+or in meaning between the first part and the
+
+227
+00:20:56,960 --> 00:20:59,420
+second part and the first sentence and the second
+
+228
+00:20:59,420 --> 00:21:03,460
+one with all the verbs we mentioned. They all
+
+229
+00:21:03,460 --> 00:21:07,780
+rejoiced to hear of his success. They all rejoiced
+
+230
+00:21:07,780 --> 00:21:12,980
+hearing of his success. Okay. Again, we have
+
+231
+00:21:12,980 --> 00:21:16,830
+difference in translation. The first sentence
+
+232
+00:21:16,830 --> 00:21:21,350
+refers to a theoretical action, an action which is
+
+233
+00:21:21,350 --> 00:21:27,210
+to happen. The second one speaks about action that
+
+234
+00:21:27,210 --> 00:21:31,010
+is fulfilled, okay? Happened, yeah. So it is the
+
+235
+00:21:31,010 --> 00:21:34,530
+same like the Bollinger principle? No, no, no. We
+
+236
+00:21:34,530 --> 00:21:37,790
+have for Bollinger principle, you have the same,
+
+237
+00:21:38,350 --> 00:21:43,390
+it started to rain. It started raining. Is there
+
+238
+00:21:43,390 --> 00:21:45,850
+any difference between the two sentences in
+
+239
+00:21:45,850 --> 00:21:51,410
+translation? We speak about start, okay? So these
+
+240
+00:21:51,410 --> 00:21:54,150
+exceptional verbs cannot meet with Bollinger's
+
+241
+00:21:54,150 --> 00:21:58,990
+principle. Now for me, I try just to avoid these
+
+242
+00:21:58,990 --> 00:22:01,230
+contradictions.
+
+243
+00:22:02,610 --> 00:22:07,530
+by dividing all verbs into four categories and
+
+244
+00:22:07,530 --> 00:22:10,630
+applying the infinitive and gerund on each
+
+245
+00:22:10,630 --> 00:22:14,350
+category to see whether this category accepts
+
+246
+00:22:14,350 --> 00:22:18,850
+infinitive and gerund or only infinitive or only
+
+247
+00:22:18,850 --> 00:22:20,730
+gerund okay.
+
+248
+00:22:24,150 --> 00:22:26,390
+Do you think that the emotive verbs of English are
+
+249
+00:22:26,390 --> 00:22:29,870
+the same like the emotive verbs of Arabic? Do you
+
+250
+00:22:29,870 --> 00:22:33,790
+have the same syntactic function? Or they differ
+
+251
+00:22:33,790 --> 00:22:37,850
+Okay,
+
+252
+00:22:38,390 --> 00:22:43,950
+we have Syntactic verbs, we have emotive verbs in
+
+253
+00:22:43,950 --> 00:23:00,590
+Arabic like يحب يكره يبغض يفضل يخاف يخشى يعجب يعشق
+
+254
+00:23:01,690 --> 00:23:06,730
+these verbs are emotive as you know okay do they
+
+255
+00:23:06,730 --> 00:23:12,630
+accept over derived nominal and modified derived
+
+256
+00:23:12,630 --> 00:23:19,650
+nominal? let's see يحب
+
+257
+00:23:19,650 --> 00:23:30,750
+زيد قراءة القرآن يحب زيد أن يقرأ القرآن so we have
+
+258
+00:23:32,390 --> 00:23:37,430
+The same, just in the verb يحب. What about others?
+
+259
+00:23:39,090 --> 00:23:46,350
+يكره الولد اللاعب في الشارع يكره الولد أن يلعب في
+
+260
+00:23:46,350 --> 00:23:53,890
+الشارع It's accepted يفضل زيد شرب الشاي يفضل زيد
+
+261
+00:23:53,890 --> 00:23:58,630
+أن يشرب الشاي يخاف
+
+262
+00:23:58,630 --> 00:24:07,250
+المعلم يخاف المؤمن ارتكاب الكبار يخاف المؤمن أن
+
+263
+00:24:07,250 --> 00:24:14,970
+يرتكب الكبار. So we have both derived and both
+
+264
+00:24:14,970 --> 00:24:19,370
+overt and covert derived nominal accepted with
+
+265
+00:24:19,370 --> 00:24:23,570
+these emotional verbs of Arabic. This means that
+
+266
+00:24:23,570 --> 00:24:27,150
+the emotive verbs of English are the same like the
+
+267
+00:24:27,150 --> 00:24:30,750
+emotive verbs of Arabic. Okay, yes.
+
+268
+00:24:33,950 --> 00:24:37,310
+We have semantic difference. Once I say, for
+
+269
+00:24:37,310 --> 00:24:44,710
+example, يكره الولد اللاعب في الشارع. يكره الولد
+
+270
+00:24:44,710 --> 00:24:49,390
+أن يلعب في الشارع. Okay? We have difference
+
+271
+00:24:49,390 --> 00:24:51,790
+semantically between the two sentences. The first
+
+272
+00:24:51,790 --> 00:24:58,290
+oneاللعبة this means that he actually plays in the
+
+273
+00:24:58,290 --> 00:25:01,590
+street at the street but he hates that there is no
+
+274
+00:25:01,590 --> 00:25:05,270
+and there is no an alternative for him however for
+
+275
+00:25:05,270 --> 00:25:09,250
+the second one he hates to play this means that he
+
+276
+00:25:09,250 --> 00:25:11,930
+does not play okay
+
+277
+00:25:24,820 --> 00:25:32,620
+I am accustomed to drink tea and I like that. This
+
+278
+00:25:32,620 --> 00:25:38,640
+means that I like to drink something that has not
+
+279
+00:25:38,640 --> 00:25:40,860
+yet happened. Okay?
+
+280
+00:25:43,960 --> 00:25:48,360
+It is of theoretical and real actions between the
+
+281
+00:25:48,360 --> 00:25:51,660
+two sentences. Again, the overt derived nominal
+
+282
+00:25:51,660 --> 00:25:57,220
+refers to real action. The covert or modified
+
+283
+00:25:57,220 --> 00:26:00,820
+derived nominal مصدر مؤور refers to an action that
+
+284
+00:26:00,820 --> 00:26:01,640
+is to happen.
+
+285
+00:26:05,360 --> 00:26:08,760
+We have the second category that is aspectual
+
+286
+00:26:08,760 --> 00:26:11,680
+verbs. Aspectual verbs.
+
+287
+00:26:18,450 --> 00:26:22,650
+So these aspectual verbs are used to indicate a
+
+288
+00:26:22,650 --> 00:26:28,310
+variety of time aspects of initiation continuation
+
+289
+00:26:28,310 --> 00:26:34,310
+repetition or termination termination of an
+
+290
+00:26:34,310 --> 00:26:43,270
+activity I mean okay these include begin okay
+
+291
+00:26:43,270 --> 00:26:46,170
+this is initiation resume
+
+292
+00:26:47,700 --> 00:26:52,360
+Initiation. Remain. This is continuation. As you
+
+293
+00:26:52,360 --> 00:26:58,780
+see. Commence. Again. Initiation. Finish.
+
+294
+00:26:59,660 --> 00:27:05,000
+Termination. Continue. This continuation. This
+
+295
+00:27:05,000 --> 00:27:10,360
+continue. Again continuation. End up. Finishing.
+
+296
+00:27:10,720 --> 00:27:16,220
+Okay. Seize. Seize.
+
+297
+00:27:18,720 --> 00:27:24,980
+seize means also finishing or termination repeat
+
+298
+00:27:24,980 --> 00:27:32,780
+repeat this is repetition complete termination
+
+299
+00:27:32,780 --> 00:27:40,040
+give up termination postpone again termination
+
+300
+00:27:40,040 --> 00:27:41,060
+proceed
+
+301
+00:27:43,570 --> 00:27:49,970
+proceed it is continuation or initiation quit quit
+
+302
+00:27:49,970 --> 00:27:59,330
+termination keep start initiation stay
+
+303
+00:27:59,330 --> 00:28:05,970
+continuation and stop termination so these
+
+304
+00:28:05,970 --> 00:28:10,150
+aspectual verbs refer to this meaning okay
+
+305
+00:28:16,320 --> 00:28:20,100
+We have the verb begin. He began to answer the
+
+306
+00:28:20,100 --> 00:28:24,120
+questions. He began answering the questions. You
+
+307
+00:28:24,120 --> 00:28:27,580
+see that all aspectual verbs we mentioned accept
+
+308
+00:28:27,580 --> 00:28:32,740
+both gerund and infinitive. He began to answer the
+
+309
+00:28:32,740 --> 00:28:35,500
+questions. He began answering the questions.
+
+310
+00:28:38,350 --> 00:28:41,390
+Still, we have difference in translation. We have
+
+311
+00:28:41,390 --> 00:28:44,250
+semantic difference between the two sentences. He
+
+312
+00:28:44,250 --> 00:28:47,590
+began to answer. This means that he prepares
+
+313
+00:28:47,590 --> 00:28:51,390
+himself to answer the question. Still, not started
+
+314
+00:28:51,390 --> 00:28:57,650
+yet. Okay? It's about to start or is to start.
+
+315
+00:28:58,110 --> 00:29:02,750
+Very, very imminent future. However, we have, he
+
+316
+00:29:02,750 --> 00:29:07,170
+began answering the questions. He started already.
+
+317
+00:29:07,930 --> 00:29:11,750
+Okay. Having said that he would be frank, we all
+
+318
+00:29:11,750 --> 00:29:17,110
+commenced to listen to him. This is theoretical.
+
+319
+00:29:18,150 --> 00:29:21,150
+Having said that he would be frank, we all
+
+320
+00:29:21,150 --> 00:29:24,950
+commenced listening to him. So this is fulfilled
+
+321
+00:29:24,950 --> 00:29:30,170
+action. Okay. Ahmed ceased to smoke while in
+
+322
+00:29:30,170 --> 00:29:36,070
+hospital. Ahmed ceased smoking while in hospital.
+
+323
+00:29:38,570 --> 00:29:42,330
+He started to drink tea. He started drinking tea.
+
+324
+00:29:43,710 --> 00:29:47,370
+There is difference here. He started to drink tea.
+
+325
+00:29:47,570 --> 00:29:53,110
+This means that he began... He likes to drink tea
+
+326
+00:29:53,110 --> 00:29:58,650
+or he accepts drinking tea once again. Okay? He
+
+327
+00:29:58,650 --> 00:30:02,590
+started drinking. This is now in the process of
+
+328
+00:30:02,590 --> 00:30:04,450
+drinking. Okay?
+
+329
+00:30:16,080 --> 00:30:22,060
+Okay, we have verbs
+
+330
+00:30:22,060 --> 00:30:28,320
+like start, begin or commence or cease they take
+
+331
+00:30:28,320 --> 00:30:35,960
+both gerund and infinitive as we mentioned here
+
+332
+00:30:35,960 --> 00:30:40,180
+semantically there is not much distinction between
+
+333
+00:30:40,180 --> 00:30:42,880
+these verbs I mean once accepting gerund or
+
+334
+00:30:42,880 --> 00:30:46,080
+infinitive mainly with the verb start begin
+
+335
+00:30:46,080 --> 00:30:52,180
+commence cease and continue the slight semantic
+
+336
+00:30:52,180 --> 00:30:57,000
+difference between the use of infinitive or gerund
+
+337
+00:30:57,000 --> 00:31:00,000
+okay
+
+338
+00:31:05,870 --> 00:31:09,690
+because they do not denote separate actions.
+
+339
+00:31:15,230 --> 00:31:22,770
+Here we have some verbs which
+
+340
+00:31:22,770 --> 00:31:27,730
+hold the meaning of possessing, which refer to
+
+341
+00:31:27,730 --> 00:31:29,330
+what is called duration of time.
+
+342
+00:31:32,730 --> 00:31:35,730
+Here we have gerund is strongly preferred. When I
+
+343
+00:31:35,730 --> 00:31:39,330
+say John finished doing his homework, I cannot say
+
+344
+00:31:39,330 --> 00:31:43,830
+John finished to do his homework. Finish only take
+
+345
+00:31:43,830 --> 00:31:51,330
+gerund because it refers to duration of time.
+
+346
+00:31:53,230 --> 00:31:58,830
+Okay? He quit smoking cigarettes. So once you
+
+347
+00:31:58,830 --> 00:32:02,460
+speak about termination verbs, You speak about
+
+348
+00:32:02,460 --> 00:32:09,020
+only gerund. Termination verbs. Okay? We'll stop
+
+349
+00:32:09,020 --> 00:32:12,580
+for an hour and resume working at three o'clock.
+
+350
+00:32:13,600 --> 00:32:19,940
+Stop. The children keep pestering their parents to
+
+351
+00:32:19,940 --> 00:32:24,040
+take them to the fair. So we have working,
+
+352
+00:32:25,240 --> 00:32:31,200
+pestering, making. okay these are gerund they came
+
+353
+00:32:31,200 --> 00:32:36,080
+directly with the verb finish the verb quit the
+
+354
+00:32:36,080 --> 00:32:44,120
+verb postpone and the verb stop okay the
+
+355
+00:32:44,120 --> 00:32:47,780
+termination verbs the termination aspectual verbs
+
+356
+00:32:47,780 --> 00:32:50,480
+take mostly gerund only
+
+357
+00:33:01,390 --> 00:33:05,830
+So these verbs, I mean the verb finish, quit,
+
+358
+00:33:06,210 --> 00:33:11,130
+postpone, resume, and keep hold the meaning of
+
+359
+00:33:11,130 --> 00:33:14,270
+duration of time. They hold the meaning of
+
+360
+00:33:14,270 --> 00:33:18,190
+duration of time. Okay?
+
+361
+00:33:21,630 --> 00:33:23,550
+So they take only gerund.
+
+362
+00:33:26,530 --> 00:33:30,840
+Do we have aspectual verbs in Arabic? Are they the
+
+363
+00:33:30,840 --> 00:33:35,600
+same like English? Do they work syntactically the
+
+364
+00:33:35,600 --> 00:33:39,860
+same as English? Do they accept overt and modified
+
+365
+00:33:39,860 --> 00:33:43,100
+derived nominal? Let's see.
+
+366
+00:33:49,310 --> 00:33:55,830
+Okay, we can quit just in this moment and next
+
+367
+00:33:55,830 --> 00:33:58,210
+time we are going to complete with aspectual verbs
+
+368
+00:33:58,210 --> 00:34:03,370
+and the rest of the other categories. So, see you
+
+369
+00:34:03,370 --> 00:34:04,350
+next time. Thank you.
+
diff --git a/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/s_eWhYP9pI0_postprocess.srt b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/s_eWhYP9pI0_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..26e8a9eb326b2d9983585fbe08b92813ad8bdc20
--- /dev/null
+++ b/PL9fwy3NUQKwa0Sd0s-XLQCrtFM4_s2KMt/s_eWhYP9pI0_postprocess.srt
@@ -0,0 +1,1464 @@
+1
+00:00:11,640 --> 00:00:15,700
+Our class today is limited for discussing the
+
+2
+00:00:15,700 --> 00:00:19,180
+sound system of English either in isolation or
+
+3
+00:00:19,180 --> 00:00:21,840
+connected speech. We are going to touch the
+
+4
+00:00:21,840 --> 00:00:25,320
+consonants, the vowels, the clusterization system,
+
+5
+00:00:26,060 --> 00:00:28,680
+the supra-segmental phoneme stress, and
+
+6
+00:00:28,680 --> 00:00:32,120
+intonation, which we have already explained just
+
+7
+00:00:32,120 --> 00:00:35,940
+in the last five lectures. Today we need to answer
+
+8
+00:00:35,940 --> 00:00:39,440
+the general questions which I gave you last time.
+
+9
+00:00:39,840 --> 00:00:44,280
+So let's answer the questions one by one. What are
+
+10
+00:00:44,280 --> 00:00:48,540
+the points of negative interference reflected in
+
+11
+00:00:48,540 --> 00:00:55,440
+pronouncing the English consonant sounds by
+
+12
+00:00:55,440 --> 00:01:01,420
+the Arab learners of English? Okay? These sounds
+
+13
+00:01:01,420 --> 00:01:03,980
+are very problematic for the Arab learners of
+
+14
+00:01:03,980 --> 00:01:04,540
+English. Why?
+
+15
+00:01:09,590 --> 00:01:12,710
+Because they are alveolar in English, but in
+
+16
+00:01:12,710 --> 00:01:13,490
+Arabic they are dental.
+
+17
+00:01:18,750 --> 00:01:28,610
+Because they are alveolar in English, while in
+
+18
+00:01:28,610 --> 00:01:32,170
+Arabic they are dental. The counterpart of Arabic
+
+19
+00:01:32,170 --> 00:01:37,030
+are dental. So you find your students pronounce
+
+20
+00:01:37,030 --> 00:01:43,700
+these sounds in dental position, okay? Changing
+
+21
+00:01:43,700 --> 00:01:48,740
+their place of articulation, okay? So instead of
+
+22
+00:01:48,740 --> 00:01:53,920
+saying, for example, zoo, they say zoo. Instead of
+
+23
+00:01:53,920 --> 00:02:01,080
+saying reed, they say reed, okay? Trailer, okay?
+
+24
+00:02:02,040 --> 00:02:06,500
+So we have some sort of negative interference
+
+25
+00:02:06,500 --> 00:02:11,870
+between these soundswhich are alveolar in English
+
+26
+00:02:11,870 --> 00:02:17,670
+while appear to be dental in Arabic. Next, the
+
+27
+00:02:17,670 --> 00:02:22,230
+next question. What's the difference between the
+
+28
+00:02:22,230 --> 00:02:27,370
+English P and B sounds and the sounds of Arabic?
+
+29
+00:02:28,270 --> 00:02:31,410
+Or and the B sound of Arabic? And the B sound of
+
+30
+00:02:31,410 --> 00:02:33,310
+Arabic? Who could answer this question?
+
+31
+00:02:36,490 --> 00:02:37,090
+Yalla.
+
+32
+00:02:42,460 --> 00:02:43,400
+Okay,
+
+33
+00:02:48,920 --> 00:02:53,900
+the difference between the pah sound and bah sound
+
+34
+00:02:53,900 --> 00:03:01,640
+of English and the bah sound of Arabic Okay
+
+35
+00:03:11,450 --> 00:03:15,210
+Okay, the difference between the PAH and BAH of
+
+36
+00:03:15,210 --> 00:03:15,710
+English.
+
+37
+00:03:18,310 --> 00:03:23,770
+They are both biliberal
+
+38
+00:03:23,770 --> 00:03:28,490
+sounds and for the manner of articulation, are
+
+39
+00:03:28,490 --> 00:03:32,770
+they the same? Yes. So what's the difference
+
+40
+00:03:32,770 --> 00:03:33,430
+between them?
+
+41
+00:03:36,430 --> 00:03:42,670
+Okay. Pa is voiced while Pa is voiceless. Do we
+
+42
+00:03:42,670 --> 00:03:48,650
+have the Pa sound in Arabic? No. But we have Pa
+
+43
+00:03:48,650 --> 00:03:53,290
+sound. We have Pa sound. Pa sound of Arabic. Is it
+
+44
+00:03:53,290 --> 00:03:57,630
+the same as its counterpart of English? Pa? What's
+
+45
+00:03:57,630 --> 00:03:58,150
+the difference?
+
+46
+00:04:06,020 --> 00:04:07,500
+In Arabic,
+
+47
+00:04:10,680 --> 00:04:14,160
+we have the two lips articulating against each
+
+48
+00:04:14,160 --> 00:04:18,120
+other. However, in Bah sound of English, you have
+
+49
+00:04:18,120 --> 00:04:24,880
+the upper lip dominating the lower lip. Okay? So
+
+50
+00:04:24,880 --> 00:04:27,040
+you find your students find difficulty in
+
+51
+00:04:27,040 --> 00:04:30,720
+pronouncing the pah sound because it's not
+
+52
+00:04:30,720 --> 00:04:35,100
+available in Arabic okay it is replaced by the
+
+53
+00:04:35,100 --> 00:04:39,160
+Arabic pah sound so instead of saying people you
+
+54
+00:04:39,160 --> 00:04:42,820
+find your students say people which is completely
+
+55
+00:04:42,820 --> 00:04:44,380
+wrong okay
+
+56
+00:05:01,310 --> 00:05:02,710
+Yes.
+
+57
+00:05:21,320 --> 00:05:25,720
+Describe the schwa vowel of English and account
+
+58
+00:05:25,720 --> 00:05:29,560
+for the difficulty the Arab learners face in
+
+59
+00:05:29,560 --> 00:05:34,840
+pronouncing it. The schwa system of English.
+
+60
+00:05:37,780 --> 00:05:39,660
+The schwa system of English.
+
+61
+00:05:45,320 --> 00:05:50,980
+Yes. So I need you to speak about Dashua system of
+
+62
+00:05:50,980 --> 00:05:53,720
+English. Yes. Dashua system is a form of... Is it
+
+63
+00:05:53,720 --> 00:05:56,720
+available in Arabic? No, not available in Arabic.
+
+64
+00:05:57,240 --> 00:06:03,420
+It is available in English. It's a weak sound. So
+
+65
+00:06:03,420 --> 00:06:06,380
+it represents the weak form of English. A weak
+
+66
+00:06:06,380 --> 00:06:11,620
+sound, yes. A Hamza, it's found in Arabic, but not
+
+67
+00:06:11,620 --> 00:06:14,960
+found in English. You mean that the Arab learners
+
+68
+00:06:15,500 --> 00:06:20,100
+move the hands and the a sound into English
+
+69
+00:06:20,100 --> 00:06:25,320
+language in place of the schwa system.
+
+70
+00:06:35,380 --> 00:06:37,440
+Like about
+
+71
+00:06:51,210 --> 00:06:55,330
+So instead of saying about they can say about
+
+72
+00:06:55,330 --> 00:07:00,990
+above they say above okay whereas there is no
+
+73
+00:07:00,990 --> 00:07:05,490
+Hamza or there is no rooted sound a in Arabic in
+
+74
+00:07:05,490 --> 00:07:09,730
+English okay we have a choice thank you very much
+
+75
+00:07:20,870 --> 00:07:24,590
+What are points of negative interference expected
+
+76
+00:07:24,590 --> 00:07:27,310
+to face Arab learners in pronouncing the long
+
+77
+00:07:27,310 --> 00:07:29,710
+vowels and diphthongs of English?
+
+78
+00:07:32,730 --> 00:07:36,750
+We have the long vowels, the diphthongs of English
+
+79
+00:07:36,750 --> 00:07:41,650
+which are of great difficulty. They represent an
+
+80
+00:07:41,650 --> 00:07:45,710
+area of difficulty. How do you expect your Arab
+
+81
+00:07:45,710 --> 00:07:51,890
+students, okay, in pronouncing such sounds? Do
+
+82
+00:07:51,890 --> 00:07:56,430
+they pronounce them correctly or not? If not, why?
+
+83
+00:07:58,530 --> 00:08:01,070
+Do you have equivalence for these sounds in
+
+84
+00:08:01,070 --> 00:08:05,950
+Arabic? Who could just answer this question? Yes?
+
+85
+00:08:12,870 --> 00:08:15,810
+You speak about the long vowels and the
+
+86
+00:08:15,810 --> 00:08:19,870
+diphthongs. How many diphthongs do you have in
+
+87
+00:08:19,870 --> 00:08:21,450
+Arabic? Is it the same like English?
+
+88
+00:08:28,390 --> 00:08:32,670
+In Arabic, we have just two diphthongs, A and I.
+
+89
+00:08:32,790 --> 00:08:35,550
+But in English, we have many diphthongs which are
+
+90
+00:08:35,550 --> 00:08:38,550
+not in the Arabic language. So we find Arabic
+
+91
+00:08:38,550 --> 00:08:41,410
+learners cannot pronounce the diphthongs of
+
+92
+00:08:41,410 --> 00:08:45,190
+English or insert the Arabic diphthongs in English
+
+93
+00:08:45,190 --> 00:08:48,030
+verses. which make their accent heavy and
+
+94
+00:08:48,030 --> 00:08:51,050
+uncorrectly. Regarding the vowels, also in Arabic
+
+95
+00:08:51,050 --> 00:08:53,990
+just we have three vowels, but in English we have
+
+96
+00:08:53,990 --> 00:08:57,410
+seven vowels. So we saw learners of Arabic face
+
+97
+00:08:57,410 --> 00:09:00,790
+difficulties in pronouncing the vowels that they
+
+98
+00:09:00,790 --> 00:09:03,810
+are not found in the Arabic language. So they
+
+99
+00:09:03,810 --> 00:09:06,210
+introduce negative interference. What do you call
+
+100
+00:09:06,210 --> 00:09:08,670
+the mistakes committed by the Arab learners once
+
+101
+00:09:08,670 --> 00:09:11,850
+they mispronounce the diphthong or the long vowel?
+
+102
+00:09:12,690 --> 00:09:16,230
+Due to their Arabic language. Is this interlingual
+
+103
+00:09:16,230 --> 00:09:21,250
+error or interlingual? Interlingual because it
+
+104
+00:09:21,250 --> 00:09:24,590
+derives from Arabic. Okay, have a seat. Thank you
+
+105
+00:09:24,590 --> 00:09:25,250
+very much.
+
+106
+00:09:29,830 --> 00:09:30,590
+Next.
+
+107
+00:09:33,110 --> 00:09:36,050
+What's the difference between constant cluster of
+
+108
+00:09:36,050 --> 00:09:39,650
+English and that of Arabic? Very easy.
+
+109
+00:10:02,520 --> 00:10:11,500
+So Arabic has two clusters.
+
+110
+00:10:14,380 --> 00:10:19,520
+So we
+
+111
+00:10:19,520 --> 00:10:24,750
+have four clusters in English. one word system
+
+112
+00:10:24,750 --> 00:10:29,410
+still we have seven clusters between or this can
+
+113
+00:10:29,410 --> 00:10:33,170
+be available between two words in connected speech
+
+114
+00:10:33,170 --> 00:10:37,670
+okay one in Arabic we have how many two clusters
+
+115
+00:10:37,670 --> 00:10:40,710
+only at the end of a word okay also there are
+
+116
+00:10:40,710 --> 00:10:43,210
+clusters in Arabic that can occur just in media
+
+117
+00:10:43,210 --> 00:10:48,360
+and finance issues while English have English has
+
+118
+00:10:48,360 --> 00:10:55,180
+clusters in initial position, middle position and
+
+119
+00:10:55,180 --> 00:10:58,680
+final position. Okay, so what do you expect the
+
+120
+00:10:58,680 --> 00:11:06,960
+Arab Leonards to do? They fracture the
+
+121
+00:11:06,960 --> 00:11:11,060
+clusterization system by inserting intrusive
+
+122
+00:11:11,060 --> 00:11:14,880
+vowels. By inserting intrusive vowels. So instead
+
+123
+00:11:14,880 --> 00:11:18,370
+of saying Spring, they said sibling, sibling. Yes,
+
+124
+00:11:18,750 --> 00:11:22,110
+instead of saying spring, they say espring or
+
+125
+00:11:22,110 --> 00:11:26,210
+espring or sibling, okay? It depends on their
+
+126
+00:11:26,210 --> 00:11:31,490
+mother tongue, okay? Good, thank you. Rasim.
+
+127
+00:11:40,770 --> 00:11:44,770
+We have constant doubling is problematic in
+
+128
+00:11:44,770 --> 00:11:50,230
+English Do you agree? Why? Consonant doubling is
+
+129
+00:11:50,230 --> 00:11:52,930
+problematic in English. Do you agree? Why?
+
+130
+00:12:07,790 --> 00:12:12,450
+First consonant doubling or consonant domination.
+
+131
+00:12:13,860 --> 00:12:17,960
+is something first is does not found in English
+
+132
+00:12:17,960 --> 00:12:23,040
+and it it can be only found in Arabic so we can we
+
+133
+00:12:23,040 --> 00:12:26,460
+can the student or the the Arabic student the
+
+134
+00:12:26,460 --> 00:12:31,120
+Arabic who learn who learn English can English as
+
+135
+00:12:31,120 --> 00:12:33,740
+a second language can insert the consonant
+
+136
+00:12:33,740 --> 00:12:37,850
+doubling when they derive or articulate the the
+
+137
+00:12:37,850 --> 00:12:42,230
+English vowel or English word in general. So, for
+
+138
+00:12:42,230 --> 00:12:46,670
+example, when I say, for example, when I say, for
+
+139
+00:12:46,670 --> 00:12:53,430
+example, allow, some students maybe see or may say
+
+140
+00:12:53,430 --> 00:13:01,630
+allow. They insert the denomination system in
+
+141
+00:13:01,630 --> 00:13:05,110
+these two consonants. So you mean that
+
+142
+00:13:05,110 --> 00:13:07,670
+denomination is only found in Arabic? Yeah, it is
+
+143
+00:13:07,670 --> 00:13:09,450
+always found in Arabic. Okay, but it is not found
+
+144
+00:13:09,450 --> 00:13:14,070
+in English. When we say comment, we have to say
+
+145
+00:13:14,070 --> 00:13:18,170
+comment. Collapse. When we say collapse, we have
+
+146
+00:13:18,170 --> 00:13:23,210
+to say collapse. Okay? Allow, this is a correct
+
+147
+00:13:23,210 --> 00:13:28,850
+system. However, allow, this is what is done by
+
+148
+00:13:28,850 --> 00:13:32,490
+the Arab dervish. So they have two mistakes when
+
+149
+00:13:32,490 --> 00:13:36,920
+they say allow. This is the halzah. instead of one
+
+150
+00:13:36,920 --> 00:13:41,140
+and the gemination is not found originally in
+
+151
+00:13:41,140 --> 00:13:44,180
+English so I learned and this is by the way called
+
+152
+00:13:44,180 --> 00:13:49,300
+interlingual mistake because it is derived from
+
+153
+00:13:49,300 --> 00:13:53,080
+the Arabic system very good thank you very much
+
+154
+00:13:53,080 --> 00:14:00,840
+what's
+
+155
+00:14:00,840 --> 00:14:02,980
+the difference between the rhythm system of
+
+156
+00:14:02,980 --> 00:14:07,620
+English and that of Arabic? The rhythm system of
+
+157
+00:14:07,620 --> 00:14:10,140
+English and that of Arabic. It's a very easy
+
+158
+00:14:10,140 --> 00:14:16,640
+question. What is
+
+159
+00:14:16,640 --> 00:14:22,620
+the
+
+160
+00:14:22,620 --> 00:14:24,540
+difference between the rhythm system in English
+
+161
+00:14:24,540 --> 00:14:26,380
+and that of Arabic? First of all, the rhythm
+
+162
+00:14:26,380 --> 00:14:28,540
+system in English is a stressed syllabus time.
+
+163
+00:14:28,640 --> 00:14:32,480
+That means it's a stressed term. While the rhythm
+
+164
+00:14:32,480 --> 00:14:36,120
+system in Arabic is a syllable time. it is
+
+165
+00:14:36,120 --> 00:14:39,440
+syllable time while in English it is stress time
+
+166
+00:14:39,440 --> 00:14:42,980
+so in English it is based I mean the rhythm of
+
+167
+00:14:42,980 --> 00:14:46,400
+English is based on time intervals however in
+
+168
+00:14:46,400 --> 00:14:49,020
+Arabic it is based on syllable intervals syllable
+
+169
+00:14:49,020 --> 00:14:51,560
+intervals do you mean that every single word is
+
+170
+00:14:51,560 --> 00:14:54,200
+stressed in Arabic? no every single word is
+
+171
+00:14:54,200 --> 00:14:58,640
+stressed however in English not every single word
+
+172
+00:14:58,640 --> 00:15:02,620
+is stressed not every single word is stressed in
+
+173
+00:15:02,620 --> 00:15:05,800
+English okay So the big boy has written a good
+
+174
+00:15:05,800 --> 00:15:09,540
+record. The big boy has written a good record. You
+
+175
+00:15:09,540 --> 00:15:12,360
+can't say the big boy has written a good record.
+
+176
+00:15:12,500 --> 00:15:17,380
+This is Arabic. Okay? However, in Arabic we say
+
+177
+00:15:17,380 --> 00:15:19,440
+كتب الولد تقريرا جيدا.
+
+178
+00:15:22,920 --> 00:15:27,240
+Every single word is stressed. Okay, I see. Very
+
+179
+00:15:27,240 --> 00:15:27,960
+good. Thank you.
+
+180
+00:15:34,420 --> 00:15:37,040
+English stress system is very difficult for Arab
+
+181
+00:15:37,040 --> 00:15:40,400
+learners to master. Do you agree? Why?
+
+182
+00:15:49,230 --> 00:15:52,570
+Yes, we agree that English system is very
+
+183
+00:15:52,570 --> 00:15:55,870
+difficult for learners because many words of
+
+184
+00:15:55,870 --> 00:15:59,730
+English are derived from different languages and
+
+185
+00:15:59,730 --> 00:16:05,410
+origins, so we don't have similar rules for all
+
+186
+00:16:05,410 --> 00:16:09,770
+words. So English words derived from different
+
+187
+00:16:09,770 --> 00:16:13,570
+origins, okay? Many of the English words are
+
+188
+00:16:13,570 --> 00:16:16,570
+borrowed from other languages. So every single
+
+189
+00:16:16,570 --> 00:16:19,210
+word borrowed from other language comes with its
+
+190
+00:16:19,210 --> 00:16:23,090
+own language system. So this means that the stress
+
+191
+00:16:23,090 --> 00:16:27,330
+is not bound to a certain rule in English. While
+
+192
+00:16:27,330 --> 00:16:31,910
+in Arabic, it is rule-based. Okay? Is this the
+
+193
+00:16:31,910 --> 00:16:36,570
+only difficulty? Is this the only difficulty the
+
+194
+00:16:36,570 --> 00:16:40,510
+Arab learners face? Here we have for English, we
+
+195
+00:16:40,510 --> 00:16:43,050
+don't have a specific rule for that. We have to
+
+196
+00:16:43,050 --> 00:16:47,470
+only estimate rules that rely on what is called
+
+197
+00:16:47,470 --> 00:16:52,530
+the suffix system okay the suffix system or the
+
+198
+00:16:52,530 --> 00:16:56,330
+prefix system of English however in Arabic the
+
+199
+00:16:56,330 --> 00:16:58,990
+situation is different everything is different
+
+200
+00:16:58,990 --> 00:17:03,050
+every single word is stressed not necessarily to
+
+201
+00:17:03,050 --> 00:17:05,830
+have every single word stressed in English mainly
+
+202
+00:17:05,830 --> 00:17:10,430
+because in English we have weak forms for example
+
+203
+00:17:10,430 --> 00:17:17,210
+what about the weak forms of English The one
+
+204
+00:17:17,210 --> 00:17:22,190
+-syllable word in isolation is stressed while not
+
+205
+00:17:22,190 --> 00:17:25,810
+stressed in connected speech. What else?
+
+206
+00:17:27,370 --> 00:17:31,470
+Conjunctions. They are weak forms. Pronouns.
+
+207
+00:17:32,890 --> 00:17:36,550
+Articles. Prepositions.
+
+208
+00:17:38,750 --> 00:17:43,650
+Contractions. These are all together weak forms in
+
+209
+00:17:43,650 --> 00:17:47,930
+English. However, they are not like so in Arabic.
+
+210
+00:17:53,390 --> 00:17:57,830
+This just makes some sort of difficulty for the
+
+211
+00:17:57,830 --> 00:18:01,050
+Arab learners. They fall in what is called
+
+212
+00:18:01,050 --> 00:18:05,310
+negative interference errors, interlingual
+
+213
+00:18:05,310 --> 00:18:09,930
+mistakes. Trace the types of intonation in English
+
+214
+00:18:09,930 --> 00:18:13,350
+and their functions, illustrating your answer with
+
+215
+00:18:13,350 --> 00:18:13,910
+examples.
+
+216
+00:18:21,150 --> 00:18:24,710
+You either mention the six types according to
+
+217
+00:18:24,710 --> 00:18:27,890
+Kharma and Hajjaj or mention only two types, the
+
+218
+00:18:27,890 --> 00:18:32,070
+falling and rising, okay? How many pitches are
+
+219
+00:18:32,070 --> 00:18:36,110
+there in English? There are four pitches, the low,
+
+220
+00:18:36,750 --> 00:18:42,110
+medium, high, rise. If we refer to them in
+
+221
+00:18:42,110 --> 00:18:46,770
+numbers, we say one, two, three, four. So you can
+
+222
+00:18:46,770 --> 00:18:49,110
+speak about the declarative sentence, the question
+
+223
+00:18:49,110 --> 00:18:52,970
+tag, the WH questions, the vocatives, the other
+
+224
+00:18:52,970 --> 00:18:58,470
+forms. So who could answer this question? The
+
+225
+00:18:58,470 --> 00:19:01,330
+intonation.
+
+226
+00:19:05,770 --> 00:19:07,030
+It's very easy.
+
+227
+00:19:13,690 --> 00:19:14,370
+Yalla.
+
+228
+00:19:22,260 --> 00:19:23,360
+God Bless.
+
+229
+00:19:52,930 --> 00:19:59,670
+So for example the declarative sentences are rise
+
+230
+00:19:59,670 --> 00:20:05,430
+for then the military positions rise forward yes
+
+231
+00:20:05,430 --> 00:20:12,010
+no questions mid rise rise or high high then the
+
+232
+00:20:12,010 --> 00:20:16,750
+question tag it's either mid rise rise or mid rise
+
+233
+00:20:16,750 --> 00:20:21,390
+four okay fine now do you have the same system in
+
+234
+00:20:21,390 --> 00:20:28,150
+Arabic it's not the same system okay Arabic has
+
+235
+00:20:28,150 --> 00:20:31,940
+only three types of integration applicable to the
+
+236
+00:20:31,940 --> 00:20:35,600
+question tag, the yes-no question, and the
+
+237
+00:20:35,600 --> 00:20:39,760
+vocatives along with the attitudinal intonation
+
+238
+00:20:39,760 --> 00:20:43,440
+which is available for English and Arabic. Okay?
+
+239
+00:20:43,520 --> 00:20:51,720
+In English we have falling pitch, but in Arabic we
+
+240
+00:20:51,720 --> 00:20:55,900
+have rising pitch. Yes. No, no. In Arabic we have
+
+241
+00:20:55,900 --> 00:21:02,360
+falling pitch. It's rise, fall. Okay? Yes. and yes
+
+242
+00:21:02,360 --> 00:21:05,840
+no question in Arabic we have rising in relation
+
+243
+00:21:05,840 --> 00:21:10,340
+in English it is rising yes however the question
+
+244
+00:21:10,340 --> 00:21:13,580
+tag in Arabic is rising while in English can be
+
+245
+00:21:13,580 --> 00:21:21,080
+rising or falling okay okay fine thank you
+
+246
+00:21:36,600 --> 00:21:41,460
+Yes. So number 10, what's the difference between
+
+247
+00:21:41,460 --> 00:21:43,620
+the intonation system of English we have already
+
+248
+00:21:43,620 --> 00:21:47,440
+explained it. Suggest suitable activities for
+
+249
+00:21:47,440 --> 00:21:51,060
+teaching each of the following, the sound system
+
+250
+00:21:51,060 --> 00:21:54,940
+in isolation, sound in connected speech, stress
+
+251
+00:21:54,940 --> 00:21:59,340
+and intonation. We have already introduced these
+
+252
+00:21:59,340 --> 00:22:04,650
+activities last lecture. Okay. So if anyone has a
+
+253
+00:22:04,650 --> 00:22:07,230
+PowerPoint about these points or this question,
+
+254
+00:22:08,290 --> 00:22:10,610
+you can submit it to us at the end of the class,
+
+255
+00:22:11,190 --> 00:22:18,690
+okay? I will consider it for you. Now, for next
+
+256
+00:22:18,690 --> 00:22:23,460
+time, we need to introduce word formation. word
+
+257
+00:22:23,460 --> 00:22:27,880
+formation, how words in English are formulated.
+
+258
+00:22:28,660 --> 00:22:32,680
+Okay? You are familiar with what is called the
+
+259
+00:22:32,680 --> 00:22:37,520
+affixation system or the affix in English. This
+
+260
+00:22:37,520 --> 00:22:45,860
+means suffix, prefix, and infix. Okay? We have
+
+261
+00:22:45,860 --> 00:22:51,160
+three types. Okay? They are added to morphemes. so
+
+262
+00:22:51,160 --> 00:22:54,540
+we have free morphine and what is called bound
+
+263
+00:22:54,540 --> 00:23:00,420
+morphine okay we need you just to revise these and
+
+264
+00:23:00,420 --> 00:23:04,080
+recall them okay you have already taken this in
+
+265
+00:23:04,080 --> 00:23:08,740
+linguistics linguistic classes last semester so I
+
+266
+00:23:08,740 --> 00:23:12,100
+need you to recall them to refresh your memory and
+
+267
+00:23:12,100 --> 00:23:16,460
+come next time ready for just discussing them and
+
+268
+00:23:16,460 --> 00:23:17,500
+being
+
+269
+00:23:20,930 --> 00:23:25,410
+exposed to the explanation of the word formation.
+
+270
+00:23:25,690 --> 00:23:30,030
+We need to explain the derivation system of
+
+271
+00:23:30,030 --> 00:23:33,910
+English, the inflection system of English, and the
+
+272
+00:23:33,910 --> 00:23:37,490
+compounding system of English compared with
+
+273
+00:23:37,490 --> 00:23:40,930
+Arabic, because this class is comparative
+
+274
+00:23:40,930 --> 00:23:47,170
+linguistics. For the word formation, we have the
+
+275
+00:23:47,170 --> 00:23:54,860
+morphemes of English either free or bound every
+
+276
+00:23:54,860 --> 00:23:59,760
+single word may have a suffix or prefix or both
+
+277
+00:23:59,760 --> 00:24:04,760
+suffix and prefix and some words have some sort of
+
+278
+00:24:04,760 --> 00:24:08,760
+infix which is quite rare in English while very
+
+279
+00:24:08,760 --> 00:24:17,520
+wide in Arabic I say مكتب or كتب مكتب مكتب مكاتب
+
+280
+00:24:17,520 --> 00:24:23,360
+كاتب Okay, so we have the infix available very
+
+281
+00:24:23,360 --> 00:24:27,380
+clearly or also we have prefix and we have suffix
+
+282
+00:24:27,380 --> 00:24:31,600
+in Arabic Okay, but not in the same scale as
+
+283
+00:24:31,600 --> 00:24:35,380
+English because you know English is of different
+
+284
+00:24:35,380 --> 00:24:38,840
+is borrowed from different languages borrowed from
+
+285
+00:24:38,840 --> 00:24:42,760
+different from different languages. So you have
+
+286
+00:24:42,760 --> 00:24:47,510
+different systems of suffixation and prefixation
+
+287
+00:24:47,510 --> 00:24:51,550
+systems okay you have prefixes and suffixes that
+
+288
+00:24:51,550 --> 00:24:55,070
+differ okay you have lots of prefixes and suffixes
+
+289
+00:24:55,070 --> 00:24:58,250
+in English either for nouns for verbs for
+
+290
+00:24:58,250 --> 00:25:04,330
+adjectives for even conjunctions
+
+291
+00:25:05,590 --> 00:25:09,610
+Okay? So we need to touch all these areas and see
+
+292
+00:25:09,610 --> 00:25:14,950
+how is derivation is available in English. How is
+
+293
+00:25:14,950 --> 00:25:18,290
+derivation available in English? And is it the
+
+294
+00:25:18,290 --> 00:25:21,630
+same? Is it with the same system as that of Arabic
+
+295
+00:25:21,630 --> 00:25:24,290
+or difference? We need to speak about the
+
+296
+00:25:24,290 --> 00:25:27,330
+inflection system. Okay? We mean by the
+
+297
+00:25:27,330 --> 00:25:31,130
+inflection, the inflection phrase, which is of
+
+298
+00:25:31,130 --> 00:25:32,750
+tense.
+
+299
+00:25:34,460 --> 00:25:43,050
+person, number, gender, case, mood. This is
+
+300
+00:25:43,050 --> 00:25:46,990
+English. It's available in all natural languages,
+
+301
+00:25:47,610 --> 00:25:51,950
+the inflection phrase. But it's different from one
+
+302
+00:25:51,950 --> 00:25:56,330
+language. I mean, the elements or the constituents
+
+303
+00:25:56,330 --> 00:26:00,110
+differ from one language to another in case of
+
+304
+00:26:00,110 --> 00:26:02,850
+having the inflection phrase. So, for example,
+
+305
+00:26:03,590 --> 00:26:07,070
+English and Arabic and all natural languages have
+
+306
+00:26:07,070 --> 00:26:11,950
+tenses. How many tenses are there in English? How
+
+307
+00:26:11,950 --> 00:26:17,580
+many tenses are there in English? Three? Six?
+
+308
+00:26:17,720 --> 00:26:18,080
+Seven?
+
+309
+00:26:23,280 --> 00:26:30,780
+Ten? We only have two tenses. We only have two
+
+310
+00:26:30,780 --> 00:26:34,940
+tenses in English. We only have two tenses in
+
+311
+00:26:34,940 --> 00:26:39,140
+English and Arabic and all natural languages. So
+
+312
+00:26:39,140 --> 00:26:42,480
+you are mistaken once you say three or seven or
+
+313
+00:26:42,480 --> 00:26:47,920
+ten or etc. We only have two. This is present and
+
+314
+00:26:47,920 --> 00:26:52,580
+past. This is English, it is Arabic, it is all
+
+315
+00:26:52,580 --> 00:26:58,120
+natural languages. Okay? So we need to see these
+
+316
+00:26:58,120 --> 00:27:02,000
+two tenses and then shift to what is called
+
+317
+00:27:02,000 --> 00:27:05,980
+person. How many types of persons are there in
+
+318
+00:27:05,980 --> 00:27:13,270
+English? Three? I mean the overt person in
+
+319
+00:27:13,270 --> 00:27:17,570
+English. The visible person.
+
+320
+00:27:22,830 --> 00:27:30,250
+Two? Four? American. We have only one. That is the
+
+321
+00:27:30,250 --> 00:27:34,930
+subject-verb agreement, S. She goes. She
+
+322
+00:27:34,930 --> 00:27:42,220
+understands. She comes. He comes. The S concord
+
+323
+00:27:42,220 --> 00:27:46,000
+added to the verb in case of having subject-verb
+
+324
+00:27:46,000 --> 00:27:51,680
+agreement, okay? However, in Arabic, do you have
+
+325
+00:27:51,680 --> 00:27:57,680
+the same? Can you have one person in Arabic? We
+
+326
+00:27:57,680 --> 00:28:01,480
+have how many? I mean the inflections added to the
+
+327
+00:28:01,480 --> 00:28:04,560
+verb. We've seen one in English, that is the S.
+
+328
+00:28:07,030 --> 00:28:12,310
+Third-person agreement. So what about Arabic? We
+
+329
+00:28:12,310 --> 00:28:21,990
+have four persons, okay? I say أكتب، يكتب، تكتب،
+
+330
+00:28:21,990 --> 00:28:30,570
+نكتب. So we have أ، ي، ت، ن، أنايته، أنايت. Okay?
+
+331
+00:28:31,010 --> 00:28:36,510
+So we have first person, second person, third
+
+332
+00:28:36,510 --> 00:28:42,110
+person with two inflections however in English we
+
+333
+00:28:42,110 --> 00:28:48,870
+only have the third person singular s okay gender
+
+334
+00:28:48,870 --> 00:28:54,590
+do you have gender in English we
+
+335
+00:28:54,590 --> 00:28:58,610
+don't have gender in English she writes he writes
+
+336
+00:28:58,610 --> 00:29:03,490
+they write we write you write however
+
+337
+00:29:05,710 --> 00:29:14,730
+يكتب تكتب يكتبان تكتبان يكتبون يكتبنا so gender is
+
+338
+00:29:14,730 --> 00:29:19,830
+available very clearly in Arabic Arabic is rich of
+
+339
+00:29:19,830 --> 00:29:27,810
+gender okay case do you have case in English is it
+
+340
+00:29:27,810 --> 00:29:34,220
+ovate or covert yes is it visible or invisible So
+
+341
+00:29:34,220 --> 00:29:38,000
+it is covert. So we have the nominative case, the
+
+342
+00:29:38,000 --> 00:29:40,500
+accusative case, and the genitive case which are
+
+343
+00:29:40,500 --> 00:29:45,360
+available in English but covertly. However, in
+
+344
+00:29:45,360 --> 00:29:50,160
+Arabic they are overt. كتب الولد الدرسة
+
+345
+00:30:11,240 --> 00:30:16,500
+So we have the inflection that explains the
+
+346
+00:30:16,500 --> 00:30:20,760
+sentence of Arabic very very clearly however this
+
+347
+00:30:20,760 --> 00:30:26,540
+is not available in English okay Parsing is
+
+348
+00:30:26,540 --> 00:30:29,980
+available in the two languages, in Arab, but it is
+
+349
+00:30:29,980 --> 00:30:33,720
+covert in English while overt in Arabic. Still, we
+
+350
+00:30:33,720 --> 00:30:38,980
+have mood. Mood is available in both languages.
+
+351
+00:30:40,180 --> 00:30:43,920
+Okay? So, we have what is called,
+
+352
+00:30:47,420 --> 00:30:52,540
+it's necessary that everyone abide to the law. If
+
+353
+00:30:52,540 --> 00:30:55,490
+you could just write down. Write down in your
+
+354
+00:30:55,490 --> 00:31:02,070
+notebooks, it's necessary that everyone abide to
+
+355
+00:31:02,070 --> 00:31:02,470
+the law.
+
+356
+00:31:05,250 --> 00:31:10,930
+It's necessary that everyone should abide to the
+
+357
+00:31:10,930 --> 00:31:16,990
+law. It's necessary for everyone to abide to the
+
+358
+00:31:16,990 --> 00:31:17,210
+law.
+
+359
+00:31:20,250 --> 00:31:27,270
+I repeat, It is necessary that everyone abide to
+
+360
+00:31:27,270 --> 00:31:34,370
+the law. Next, it's necessary that everyone should
+
+361
+00:31:34,370 --> 00:31:40,750
+abide to the law. Next, it's necessary for
+
+362
+00:31:40,750 --> 00:31:44,250
+everyone to abide to the law. I need you to
+
+363
+00:31:44,250 --> 00:31:47,330
+translate these three sentences and come ready for
+
+364
+00:31:47,330 --> 00:31:50,650
+discussion next time. That's it for today. Thank
+
+365
+00:31:50,650 --> 00:31:50,810
+you.
+
+366
+00:31:53,890 --> 00:31:55,050
+Yeah.
+