diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/1-iWE_Sbnvw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/1-iWE_Sbnvw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b0dac09909a93966fbbfbe923c3dd2a665c6b36c
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/1-iWE_Sbnvw.srt
@@ -0,0 +1,3214 @@
+1
+00:00:03,500 --> 00:00:10,420
+أيه؟ أين راحت؟ اسمعني لكي أعمل share screen
+
+2
+00:00:10,420 --> 00:00:16,820
+share screen طيب
+
+3
+00:00:16,820 --> 00:00:25,200
+بسم الله الرحمن الرحيم، بالنسبة
+
+4
+00:00:25,200 --> 00:00:34,630
+لِـ إن شاء الله، محاضرة اليوم راح نتكلم عن يعني
+
+5
+00:00:34,630 --> 00:00:43,310
+تطبيقات في جانب مهم من الأمراض الوراثية والوراثة
+
+6
+00:00:43,310 --> 00:00:50,390
+ومبادئها على الجانب المهم وهو الدم، الـHemoglobin
+
+7
+00:00:50,390 --> 00:00:53,630
+فبالنسبة
+
+8
+00:00:53,630 --> 00:00:59,920
+لكتابكم، إحنا بشكل عام، ما كنت حابب أنه كمبادئ للـ
+
+9
+00:00:59,920 --> 00:01:04,320
+Genetics، أن ندخل في الـSpecific Diseases والـ
+
+10
+00:01:04,320 --> 00:01:09,440
+Specific Conditions، بس أحيانًا تضطر عشان تفهم
+
+11
+00:01:09,440 --> 00:01:15,000
+الموضوع تمامًا من ناحية الوراثة في جانب معين ويكون
+
+12
+00:01:15,000 --> 00:01:21,020
+مهم إنك تدرس مثال عليها، وتفهم كيف إحنا الآن في
+
+13
+00:01:21,020 --> 00:01:28,040
+العصر الحالي، وبنربط الجينات
+
+14
+00:01:28,040 --> 00:01:34,480
+بتفاصيلها الدقيقة بالحالات والأمراض، ونشوف كيف
+
+15
+00:01:34,480 --> 00:01:41,520
+تنتقل من جين على مستوى الـDNA لمستوى إنه يكون مرض
+
+16
+00:01:41,520 --> 00:01:46,680
+عند الإنسان، بس قبل ما ندخل في المحاضرة وندخل في
+
+17
+00:01:46,680 --> 00:01:50,980
+تفاصيل
+
+18
+00:01:50,980 --> 00:01:58,410
+الأمور، كنت بدي أبدأ بسؤال اللي اعتقدتمه يعني
+
+19
+00:01:58,410 --> 00:02:06,950
+افترضنا إنه إحنا صوّينا الـ
+
+20
+00:02:06,950 --> 00:02:15,630
+ABO type للـBadge تبعتكم حوالي 151، وشوفنا
+
+21
+00:02:15,630 --> 00:02:20,030
+الـfrequency of the alleles، آسف، الـfrequency of
+
+22
+00:02:20,030 --> 00:02:24,980
+the types، حطيت أنا النسب هذه، صراحة السؤال غلط
+
+23
+00:02:24,980 --> 00:02:31,000
+ومنحلش من ناحية إنه أنا اللي حطيته نسب هيك من رأسي
+
+24
+00:02:31,000 --> 00:02:36,140
+جمعت أن يكونوا 100، وحطيتها هيك يعني، وهذا كان سؤال
+
+25
+00:02:36,140 --> 00:02:46,260
+خاطر يعني، مش هيك، بس الحل، الحل كان إن الواحد يمسك
+
+26
+00:02:46,260 --> 00:02:52,260
+في الأشياء القوية الواضحة اللي يعني الها معلومات
+
+27
+00:02:52,260 --> 00:03:00,740
+مفيدة، وفيه صراحة رقمين يعني صحيحة بالنسبة
+
+28
+00:03:00,740 --> 00:03:09,680
+كأرقام نسب، حتى تهيكة بذكر فيه معادلتين، المعادلة
+
+29
+00:03:09,680 --> 00:03:16,260
+الأولى إنه إذا أخذنا عنا Two alleles، إذا كانوا
+
+30
+00:03:16,260 --> 00:03:23,940
+في one certain locus، إذا المعادلتين بتقول إنه الـP
+
+31
+00:03:23,940 --> 00:03:30,280
+زائد الـQ بيساوي 1، والـP تربيع زائد 2PQ زائد Q تربيع
+
+32
+00:03:30,280 --> 00:03:33,600
+بيساوي 1، دائماً الرقمين اللي بدنا نستخدمهم
+
+33
+00:03:33,600 --> 00:03:37,720
+بالمعادلتين المهمات عشان الواحد في الواحد يدبر حاله
+
+34
+00:03:37,720 --> 00:03:44,480
+فإذا افترضنا إن الـO type 30%، الـO type هو
+
+35
+00:03:44,480 --> 00:03:51,120
+الـRecessive، وبالتالي حتى يظهر لازم يكون homozygous
+
+36
+00:03:51,120 --> 00:03:57,180
+لازم يكون pure، لازم يكون ينتمي من الـO، فإذا الـQ
+
+37
+00:03:57,180 --> 00:04:01,680
+تربيع بيساوي يعني هو أنا بدأنا ناخد الـQ تربيع لأن
+
+38
+00:04:01,680 --> 00:04:11,140
+هذه نسبة الـO، فبتكون 0.3، فالـQ بتكون 0.548
+
+39
+00:04:11,140 --> 00:04:18,420
+يعني 55% تقريبًا، حتى كجين على مستوى الجيل، حيث إنه
+
+40
+00:04:18,420 --> 00:04:25,080
+يكون 30% recessive لهذه الدرجة واضح، وبالتالي إحنا
+
+41
+00:04:25,080 --> 00:04:33,680
+أنا كان يعني صحيح حصلت اثنين بس يعني الـA والـB
+
+42
+00:04:33,680 --> 00:04:41,480
+المرة هذه يعني مش بس one، one allele غير الـO
+
+43
+00:04:41,480 --> 00:04:45,940
+الـdominant، يعني عندي اثنين dominant، الـA والـB
+
+44
+00:04:47,160 --> 00:04:52,120
+وكنت أنا بدي أقول إن الـFrequency تبعتهم اللي هي
+
+45
+00:04:52,120 --> 00:05:01,520
+الـA زي الـB، بيساوي البقية، لأنه راح يكونوا عبارة عن
+
+46
+00:05:01,520 --> 00:05:07,760
+اللي أخذنا معادلة الـB زي الـQ، بيساوي واحد، والـQ
+
+47
+00:05:07,760 --> 00:05:12,920
+طلعت هالقد، هاي الـB اللي هي الـFrequency تبعت
+
+48
+00:05:12,920 --> 00:05:21,160
+الـA والـB بيساوي اللي هو الـP، اللي هي بقية الواحد
+
+49
+00:05:21,160 --> 00:05:29,260
+فهيكون إن الـX والـY بيساوي 0.452، فإن هذه
+
+50
+00:05:29,260 --> 00:05:37,540
+معادلتين ماشي، والنقطة المهمة من النسب اللي إحنا
+
+51
+00:05:37,540 --> 00:05:43,620
+حصلنا عليها، اللي هو الـAB، الـAB is codominant
+
+52
+00:05:44,380 --> 00:05:51,280
+يعني الـ"A" ظاهر والـ"B" ظاهر، فحتى نشوف نسبة الـ
+
+53
+00:05:51,280 --> 00:05:57,720
+Frequency هذه في الـPopulation، بتكون "X" ضرب
+
+54
+00:05:57,720 --> 00:06:04,120
+"Y" بيساوي 26%، فصراحة لما جينا نحل المعادلتين
+
+55
+00:06:04,120 --> 00:06:10,740
+بمجهولين، ونقدر بالرياضيات نحلها، هيك الأصل وأنا
+
+56
+00:06:10,740 --> 00:06:15,930
+فكرت أن هيك بتقدر بسهولة الواحد يطلع النسب كلهم
+
+57
+00:06:15,930 --> 00:06:22,090
+ويطبقها، الصراحة طلعت ما تنحل بسبب إن الأرقام مش
+
+58
+00:06:22,090 --> 00:06:27,730
+مظبوطة، يعني ما فيش أرقام بتحقق هذه النسب بهذه
+
+59
+00:06:27,730 --> 00:06:36,530
+الطريقة بشكل سليم، فبعتذر عن المثال، كان شوية مستعجل
+
+60
+00:06:36,530 --> 00:06:44,710
+وكان يعني، بكفي الواحد من هدول النسبتين اللي هو
+
+61
+00:06:44,710 --> 00:06:51,070
+يعني الـO بشكل واضح، والـA و الـB بشكل واضح، الواحد
+
+62
+00:06:51,070 --> 00:06:58,250
+كان ممكن يطلع كل الأرقام، والأصل أنه كان أنا طلعت
+
+63
+00:06:58,250 --> 00:07:03,550
+الإجابات وحطيت شو هي النسب، وأعطيتكم إياها عشان
+
+64
+00:07:03,550 --> 00:07:10,770
+تحلوهم، بس أتوقع يعني كـExercise الواحد بده يشوف
+
+65
+00:07:10,770 --> 00:07:18,830
+لما يقرأ، والواحد، طلابكم، أحد زملائكم ذكر إنه هو
+
+66
+00:07:18,830 --> 00:07:25,130
+اطلع على study وشاف فيها النسب وكيف كانت طلعوهم
+
+67
+00:07:25,130 --> 00:07:31,290
+وكذا، بس بتكون من هذا المبدأ، في أسئلة؟ أو في أحد
+
+68
+00:07:31,290 --> 00:07:37,390
+عنده أسئلة حتى عن الامتحان أو عن الدكتور
+
+69
+00:07:37,390 --> 00:07:44,540
+أحمد، أنا عادة بالنسبة للامتحانات بحط جزء من سواء
+
+70
+00:07:44,540 --> 00:07:50,020
+المحاضرة، أو إذا كان الناس بيسموه الـOSCE والـ
+
+71
+00:07:50,020 --> 00:07:56,360
+Mini OSCE وكذا، بحط إنه نجاوب الأسئلة، يعني ما عندي
+
+72
+00:07:56,360 --> 00:08:04,100
+مشكلة، إنه جزء من المحاضرة الجاية بحط الأسئلة و
+
+73
+00:08:04,100 --> 00:08:09,660
+نقرأ شو الإجابات كانت، حتى الواحد ينتبه، في أسئلة قبل
+
+74
+00:08:09,660 --> 00:08:22,060
+ما نبدأ يا شباب ويا دكتورات، الأسئلة
+
+75
+00:08:22,060 --> 00:08:27,020
+المعتادة يعني بيسألوا قاعدين عن النص، في أي شباب
+
+76
+00:08:27,020 --> 00:08:31,240
+اللي راح يكون، أما الأمور، الامتحانات وترتيبها ما
+
+77
+00:08:31,240 --> 00:08:34,160
+بدنا إياها هنا، سبب نسأل الـGenetics، حد عنده سؤال في
+
+78
+00:08:34,160 --> 00:08:34,820
+الـGenetics؟
+
+79
+00:08:48,290 --> 00:08:57,910
+إذا خلينا نبدأ بمحاضرة اليوم، اللي هي يعني نبدأ
+
+80
+00:08:57,910 --> 00:09:01,490
+ندخل الـMolecular Basis of Genetic Diseases،
+
+81
+00:09:01,490 --> 00:09:08,470
+الفكرة
+
+82
+00:09:08,470 --> 00:09:15,270
+هنا إنه إحنا، الإنسان إذا باعتبار أن الله سبحانه
+
+83
+00:09:15,270 --> 00:09:23,450
+وتعالى خلقه في أحسن تقويم، بطريقة مصبوطة بأحسن
+
+84
+00:09:23,450 --> 00:09:30,090
+تقويم، لما تصير mutation، كيف الـmutation هذه تتحول
+
+85
+00:09:30,090 --> 00:09:36,450
+إلى إنه الـmutation
+
+86
+00:09:36,450 --> 00:09:40,630
+هذه أو الطفرة هذه في الـDNA تتحول إنها تكون مرض،
+
+87
+00:09:41,040 --> 00:09:45,780
+تكون Disease، فالمبدأ
+
+88
+00:09:45,780 --> 00:09:55,000
+الأساسي، وهو الـGraph أو الـFigure فيه
+
+89
+00:09:55,000 --> 00:10:02,180
+يعني مبادئ أساسية، وراح ناخدها بطريقة ثانية اللي هي
+
+90
+00:10:02,180 --> 00:10:10,180
+Table بهذا الشكل، على طريقة تأثير
+
+91
+00:10:10,670 --> 00:10:16,990
+الـ"طفرة" أو الـmutation على أنها اتسببت المرض،
+
+92
+00:10:16,990 --> 00:10:24,470
+النقطة الأولى، بدل الواحد يتذكر إنه "الطفرة" هذه قد
+
+93
+00:10:24,470 --> 00:10:30,910
+تكون باحتمالين، إنها تعمل mutation in the coding
+
+94
+00:10:30,910 --> 00:10:35,590
+region، يعني في المنطقة المسئولة تمامًا عن البروتين
+
+95
+00:10:35,590 --> 00:10:45,340
+اللي ناتج عن الجين هذا، أو إنها تؤثر في جوانب أخرى
+
+96
+00:10:45,340 --> 00:10:50,700
+اللي هي التحكم في إنتاج البروتين، بحيث إنه بالأخير
+
+97
+00:10:50,700 --> 00:10:56,380
+الـprotein structure is normal، بس الـgene
+
+98
+00:10:56,380 --> 00:11:05,850
+regulation، الـdosage تبع البروتين اللي
+
+99
+00:11:05,850 --> 00:11:11,590
+قد يكون نتيجة، يعني بتذكر الواحد إن الـSnips هدول
+
+100
+00:11:11,590 --> 00:11:15,890
+Single Nucleotide Polymorphism، اللي هم Very Common
+
+101
+00:11:15,890 --> 00:11:20,870
+اللي هي تقريبًا في أي إنسان من خمس إلى عشر ملايين
+
+102
+00:11:20,870 --> 00:11:27,720
+Snips موجودة عنده، كثير منهم ما بيغيروا البروتين، ما
+
+103
+00:11:27,720 --> 00:11:31,420
+بيغيروه، يعني بيكون بالأخير هاي الـSnip إحنا
+
+104
+00:11:31,420 --> 00:11:35,900
+بنستفيد منها في التشخيص، أحيانًا في الـMarkers وكده
+
+105
+00:11:35,900 --> 00:11:42,520
+بس هي حقيقةً لا تؤثر في الوظيفة، ففي mutation، بدنا
+
+106
+00:11:42,520 --> 00:11:48,740
+نفرق بينهم، إشي تكون في الـCoding Region، بالتالي
+
+107
+00:11:48,740 --> 00:11:56,360
+بيعطينا Abnormal Proteins، أو في الـRegulation تبع
+
+108
+00:11:56,360 --> 00:12:00,640
+الـGene Expression، في حياته إنه بيصير عندي، ولو إن
+
+109
+00:12:00,640 --> 00:12:05,860
+الـProtein Structure is normal، بس الكمية أو الـ
+
+110
+00:12:05,860 --> 00:12:11,020
+Function من ناحية أخرى بتكون Abnormal، النقطة
+
+111
+00:12:11,020 --> 00:12:19,080
+الثانية إنه في أحيانًا الـGenetic Diseases اللي
+
+112
+00:12:19,080 --> 00:12:26,620
+بتأثر بالمحصلة على الـRNA Level، يعني هنا على الـ
+
+113
+00:12:26,620 --> 00:12:31,600
+Mutations Disturbing الـRNA Stability، يعني هاي
+
+114
+00:12:31,600 --> 00:12:37,100
+برضه جانب آخر، مش دائمًا أي Disease، Genetic Disease
+
+115
+00:12:37,100 --> 00:12:44,740
+بلاقي إنه في الأخير فيه يعني عندي الـDNA هو اللي
+
+116
+00:12:44,740 --> 00:12:48,760
+فيه المشكلة، أحيانًا بتصير أمراض نتيجة إن الـRNA
+
+117
+00:12:48,760 --> 00:12:54,500
+بعد ما يصير Transcription بيصير عليه مشاكل، فـ
+
+118
+00:12:56,960 --> 00:13:05,120
+الحالات الأولى لما نكون الـmutation أو الطفرة في
+
+119
+00:13:05,120 --> 00:13:11,240
+الـcoding DNA اللي هي مباشرة مسئولة عن الـ
+
+120
+00:13:11,240 --> 00:13:16,840
+protein abnormality، اللي هي هنا، فلما نكون عندنا
+
+121
+00:13:16,840 --> 00:13:22,340
+protein abnormality ممكن، إذا عندها Unstable
+
+122
+00:13:22,340 --> 00:13:31,780
+Decreased Amount، وهنا عبارة عن Hemoglobin نوعية
+
+123
+00:13:31,780 --> 00:13:35,580
+خاصة اللي هو Hammersmith، اللي هو اسم المستشفى
+
+124
+00:13:35,580 --> 00:13:41,020
+في بريطانيا اللي اكتشفوا الـHemoglobin هذا، عنده
+
+125
+00:13:41,020 --> 00:13:48,760
+فسموه بهذا الاسم، نوعية معينة ممكن أنه يكون عندي اللي
+
+126
+00:13:48,760 --> 00:13:55,570
+هي أنه Loss of the protein function، إنه أنا
+
+127
+00:13:55,570 --> 00:14:01,810
+أخبط للبروتين لأنه abnormal، صار في عندي Loss of
+
+128
+00:14:01,810 --> 00:14:06,290
+the function، أو إنه gain of functions أحيانًا
+
+129
+00:14:06,290 --> 00:14:12,390
+بيكون أقوى من اللازم، زي راح نأخذ مثال على اللي هي
+
+130
+00:14:12,390 --> 00:14:17,690
+higher مثلاً
+
+131
+00:14:17,690 --> 00:14:24,200
+Oxygen affinity للهيموجلوبين، فزادت وظيفة، يعني ماسك
+
+132
+00:14:24,200 --> 00:14:27,980
+الـHemoglobin بالأكسجين كثير، فصار الـEndogenous
+
+133
+00:14:27,980 --> 00:14:34,940
+Function أو Novel Property، يعني صفة مختلفة وجديدة
+
+134
+00:14:34,940 --> 00:14:40,600
+تمامًا نتيجة الخلل اللي صار، زي في حالات الـSickle
+
+135
+00:14:40,600 --> 00:14:44,280
+Cell Anemia، الـSickle Cell Hemoglobin اللي هو
+
+136
+00:14:44,280 --> 00:14:48,780
+بيسموه Hemoglobin S، اللي هو بيصير إنه لما ينقص
+
+137
+00:14:48,780 --> 00:14:53,760
+الأكسجين يصير الـClumping of the Hemoglobin
+
+138
+00:14:53,760 --> 00:15:01,040
+موليكول، يصير عندي Cycling ويصير عندي Disease، فهذه
+
+139
+00:15:01,040 --> 00:15:05,700
+هي ميكانيزم للمرض لما يكون عندي protein abnormal،
+
+140
+00:15:05,700 --> 00:15:13,640
+يعني المرض نتيجة سواء زيادة الـFunction، قلة الـ
+
+141
+00:15:13,640 --> 00:15:20,390
+Function، قلة البروتين، أو وظيفة جديدة تمامًا، ملاحظة
+
+142
+00:15:20,390 --> 00:15:28,430
+جديدة تمامًا، فالـProtein abnormality بيكون
+
+143
+00:15:28,430 --> 00:15:33,110
+through multiple mechanisms leading to the disease،
+
+144
+00:15:33,110 --> 00:15:38,910
+ممكن الـProtein structure is normal، بس الـ
+
+145
+00:15:38,910 --> 00:15:43,610
+mutation في الـcontrol، فبتأثر على الـdosage أو
+
+146
+00:15:43,610 --> 00:15:49,930
+level of the expression، فـDecreased amount زي
+
+147
+00:15:49,930 --> 00:15:56,690
+الثلاسيميا، راح ناخد أنواع الثلاسيميا وشو أنواعه
+
+148
+00:15:56,690 --> 00:16:01,170
+بس كمان يعني هذه الـAbnormal Structure أو الـ
+
+149
+00:16:01,170 --> 00:16:04,810
+Function، هو أنا، Abnormal Function حتى في الـTumor
+
+150
+00:16:04,810 --> 00:16:08,730
+Suppressor Mutations بتؤدي للـLoss of Function،
+
+151
+00:16:08,730 --> 00:16:16,610
+بتلاقيها بعدين في عندي، في عندي diseases نتيجة
+
+152
+00:16:16,610 --> 00:16:21,290
+السرطان، بمعنى الـCancer، الـIncreased amount بيصير
+
+153
+00:16:21,290 --> 00:16:28,370
+لنا gain of function، مثلًا Trisomy، أي عبارة عن لما
+
+154
+00:16:28,370 --> 00:16:37,210
+نكون زي ما أخذنا مثلًا Trisomy 21، وبالتالي يعني
+
+155
+00:16:37,210 --> 00:16:42,690
+الأصل أنه فيه زيادة في level of the proteins، لأنه
+
+156
+00:16:42,690 --> 00:16:46,370
+الجينات صارت أكثر، فيه مرض اسمه "Charcot-Marie
+
+157
+00:16:46,370 --> 00:16:53,430
+-Tooth Type-A"، تبارك الله، عن مرض عصبي بيصير فيه ضعف
+
+158
+00:16:53,430 --> 00:17:03,610
+العضلات وضعف الأعصاب، وهنا بتكون يعني فيه نوع من الـ
+
+159
+00:17:04,720 --> 00:17:09,700
+"Controller"، جين معين بيصير عندي زيادة، وبقى ضمن
+
+160
+00:17:09,700 --> 00:17:13,940
+إنه يتظاهر فيه أنواع X-linked وفيه تظاهر dominant
+
+161
+00:17:13,940 --> 00:17:23,700
+وفيه له أنواع مش مهمة كثير، وفي عندنا اللي هي topic
+
+162
+00:17:23,700 --> 00:17:28,840
+or heterochronic expression، راح نعطي أمثلة عنها
+
+163
+00:17:28,840 --> 00:17:34,970
+ويعني اللي هي إنه الأصل إنه فيه جينات بتشتغل وفيه
+
+164
+00:17:34,970 --> 00:17:39,970
+جينات ساكتة، في كل مرحلة من حياة الإنسان بتلاقي
+
+165
+00:17:39,970 --> 00:17:44,430
+مفروض جينات معينة هي بتشتغل، وبعدين الأشياء التانية
+
+166
+00:17:44,430 --> 00:17:50,850
+بتصير تتوقف، فإذا صار إنه الشغل والتوقيف مش مظبوط،
+
+167
+00:17:50,850 --> 00:17:54,430
+ماشي، بتصير عندي inappropriate expression and wrong
+
+168
+00:17:54,430 --> 00:17:59,690
+time or place، كانت سبب للـDisease، أنا بعتبر يعني
+
+169
+00:17:59,690 --> 00:18:08,410
+كمبادئ، قضية إيش اللي بيخرب وإيش كيف من الانتقال من
+
+170
+00:18:08,410 --> 00:18:11,730
+الـMutation لـDisease، وليه بيكون الـDisease بهذا
+
+171
+00:18:11,730 --> 00:18:19,610
+الشكل، بتكون يعني نتيجة خلل بأحد هذه الطرق، بأحد
+
+172
+00:18:19,610 --> 00:18:28,150
+هذه الـMechanisms، لما نأخذ يعني الـ8
+
+173
+00:18:28,150 --> 00:18:32,860
+Steps، بالنسبة للميوتاشيون التي يمكنها تغيير نشاط
+
+174
+00:18:32,860 --> 00:18:40,540
+البروتين، يعني هنا بيحاولوا يعطوكم كل أنواع
+
+175
+00:18:40,540 --> 00:18:50,060
+الخلل
+
+223
+00:23:53,310 --> 00:23:54,330
+أن يكون هناك ميكانيزمات باثوجينيتيك أو ممكن أن
+
+224
+00:23:54,330 --> 00:23:54,830
+يكون هناك ميكانيزمات باثوجينيتيك أو ممكن أن يكون
+
+225
+00:23:54,830 --> 00:23:55,630
+هناك ميكانيزمات باثوجينيتيك أو ممكن أن يكون هناك
+
+226
+00:23:55,630 --> 00:24:00,890
+ميكانيزمات باثوجينيتيك أو ممكن أن يكون هناك
+
+227
+00:24:00,890 --> 00:24:03,570
+ميكانيزمات باثوجينيتيك أو ممكن أن يكون هناك
+
+228
+00:24:03,570 --> 00:24:04,990
+ميكانيزمات باثوجينيتيك أو ممكن أن يكون هناك
+
+229
+00:24:04,990 --> 00:24:09,370
+ميكانيزمات باثوجينيتيك أو ممكن أن يكون هناك
+
+230
+00:24:09,370 --> 00:24:16,790
+ميكانيزمات باثوجينيتيك أو ما- ما نقول شو هما الـ
+
+231
+00:24:16,790 --> 00:24:19,670
+الـ Amino Acids اللي هو اسمه الـ Primary Structure
+
+232
+00:24:19,670 --> 00:24:23,630
+بعدين كنا بنحول لـ Secondary Structure  بعدين
+
+233
+00:24:23,630 --> 00:24:29,950
+Structure  إلى Quaternary Structure  التشكل الرابعي
+
+234
+00:24:29,950 --> 00:24:39,230
+للبروتين فالـ Folding الأول هو الـ Secondary
+
+235
+00:24:39,230 --> 00:24:42,450
+Structure، الـ Amino Acid Sequence و الـ Primary
+
+236
+00:24:42,450 --> 00:24:46,510
+Structure، الـ Folding و الـ Relationship Between
+
+237
+00:24:46,510 --> 00:24:53,210
+Nearby Amino Acids بيسموه الـ Secondary Structure
+
+238
+00:24:53,210 --> 00:24:58,290
+وبتكون نتيجة أنه بعد ما تولنا الـ Amino Acid Chain
+
+239
+00:24:58,290 --> 00:25:02,410
+لازم تتلف وتعمل الأشياء اللي لازم تتعملها
+
+240
+00:25:02,410 --> 00:25:07,420
+فبقول لكم هنا More than 70%، والـ Hemoglobinopathies
+
+241
+00:25:07,420 --> 00:25:10,940
+هي بسبب هي موجودة  بسبب  هيموغلوبين غير عادي مع تغيير الـ Amino
+
+242
+00:25:10,940 --> 00:25:18,600
+Acid زي الـ Hemoglobin Hammersmith، وبعدين في عندي
+
+243
+00:25:18,600 --> 00:25:24,220
+Post-Translational Modification، يعني مثلًا بعد ما
+
+244
+00:25:24,220 --> 00:25:28,840
+يخلص البروتين ويصير يعمل Folding، الأصل إن أنا أصير
+
+245
+00:25:28,840 --> 00:25:34,460
+مثلًا في أماكن معينة أحط Glucose أو Carbohydrate
+
+246
+00:25:43,120 --> 00:25:49,100
+بعض الأمراض، وسيضعون عليها مثلًا «مانوز 6- فوسفات»
+
+247
+00:25:49,100 --> 00:25:57,240
+إشارة إلى «مانوز»، يعني سكر، بيكون معاه
+
+248
+00:25:57,240 --> 00:26:02,820
+فوسفات، تنضج في مكان معين ضروري عشان الـ lysosomal
+
+249
+00:26:02,820 --> 00:26:10,160
+storage، وبالتالي بيسبب Disease، يعني هنا المشكلة في
+
+250
+00:26:10,160 --> 00:26:15,360
+step post-translational، بعد ما كوّنّا الـVolume
+
+251
+00:26:15,360 --> 00:26:18,420
+بتاعي وصار له الـFolding، الأصل يكون Modification
+
+252
+00:26:18,420 --> 00:26:23,040
+معينة ما بيصير بعدين
+
+253
+00:26:23,040 --> 00:26:32,300
+طبعًا الـTertiary Structure اللي هو الشكل الأخير
+
+254
+00:26:32,300 --> 00:26:40,030
+تبع البروتين، بعد ما يكون في عندنا يعني interaction
+
+255
+00:26:40,030 --> 00:26:46,110
+between amino acids which are separate، يعني الـ
+
+256
+00:26:46,110 --> 00:26:50,290
+secondary structure اللي هو الـ Alpha Helix أو الـ
+
+257
+00:26:50,290 --> 00:26:56,170
+Beta Pleated Sheets، هدولة بيكونوا مع الـ يعني
+
+258
+00:26:56,170 --> 00:26:59,630
+interaction between nearby amino acids، كل واحد مع
+
+259
+00:26:59,630 --> 00:27:04,890
+اللي بجواره، كيف بيترابط بطريقة مختلفة، اللي لما يكون
+
+260
+00:27:04,890 --> 00:27:10,370
+الـ Amino Acid بعيدة وترتبط بالذات بالـ disulphide
+
+261
+00:27:10,370 --> 00:27:18,590
+bond بين الـ cysteine amino acid residues بعيدة عن
+
+262
+00:27:18,590 --> 00:27:23,690
+بعض وتشبك مع بعض، هذه بدنا نعتبرها Tertiary
+
+263
+00:27:23,690 --> 00:27:28,730
+structure، وبالتالي assembly of monomers into
+
+264
+00:27:28,730 --> 00:27:34,780
+a homomeric protein، أحيانًا، زي وطبعًا هنا يعني
+
+265
+00:27:34,780 --> 00:27:42,520
+تعتبروها أنه التفاعل أو الـ Interaction يكون بين نسخ
+
+266
+00:27:42,520 --> 00:27:47,300
+متشابهة تمامًا من الـ polypeptide بتاع الـ chains، زي
+
+267
+00:27:47,300 --> 00:27:51,660
+الـ Collagen Triple Helix، إذا بتتركوا Structure
+
+268
+00:27:51,660 --> 00:27:55,420
+تبع الـ Collagen، فطبعًا الأمراض اللي بيكون فيها
+
+269
+00:27:55,420 --> 00:28:00,760
+Collagen Disease، زي مثلًا، معرفة عن Ehlers-Danlos Syndrome
+
+270
+00:28:00,760 --> 00:28:06,300
+أشياء زي هيك بتكون البروتين
+
+271
+00:28:06,300 --> 00:28:14,180
+شكله ويكون أنه كل الجين اللي هو من تلات جدائل
+
+272
+00:28:14,180 --> 00:28:19,400
+مرتبطة مع بعض، في أحيانًا subcellular localization
+
+273
+00:28:19,400 --> 00:28:24,200
+of a polypeptide أو a homomer، يعني زي الـfamily
+
+274
+00:28:24,200 --> 00:28:29,750
+الـhypercholesterolemic mutation مثلًا، وين البروتين هذا
+
+275
+00:28:29,750 --> 00:28:34,310
+بيروح في القليل، وين يكون هذا، برضه أحيانًا بيكون فيه
+
+276
+00:28:34,310 --> 00:28:38,730
+defect in Co-factor or prosthetic group binding to
+
+277
+00:28:38,730 --> 00:28:42,790
+a polypeptide، يعني أحيانًا حتى يشتغل بالذات
+
+278
+00:28:42,790 --> 00:28:50,310
+الإنزيمات بدنا Co-factor، الـ Polypeptide chain
+
+279
+00:28:50,310 --> 00:28:59,350
+بيسموها الـ apoenzyme، والـ holoenzyme أو اللي هو
+
+280
+00:28:59,350 --> 00:29:03,970
+الـ الـ small  أو الـ cofactor بيكون هو الشيء
+
+281
+00:29:03,970 --> 00:29:10,790
+الصغير المطلوب عشان كل أنزايم أو بروتين يشتغل
+
+282
+00:29:10,790 --> 00:29:18,590
+أحيانًا الـ mutation بتضرب هذا الـ interaction بين
+
+283
+00:29:18,590 --> 00:29:25,440
+الـ الـ quality بتاع الـ chain مع الـ Co-Factor
+
+284
+00:29:25,440 --> 00:29:29,220
+المطلوب، يعني
+
+285
+00:29:29,220 --> 00:29:32,360
+النتيجة
+
+286
+00:29:32,360 --> 00:29:38,860
+الأخير اللي هو زي الـ Sickle Cell ماشي، أو غيره
+
+287
+00:29:38,860 --> 00:29:45,260
+كمثال،  هيموغلوبين يكون أن الـ Function زادت
+
+288
+00:29:45,260 --> 00:29:50,720
+نتيجة أن البروتين
+
+289
+00:29:50,720 --> 00:29:58,790
+زاد في الـ Amount، أو شغله صار أقوى وأكثر مما هو
+
+290
+00:29:58,790 --> 00:30:06,910
+مطلوب، راح نأخذ أمثلة عليها، فهدولة الأمثلة على كيف
+
+291
+00:30:06,910 --> 00:30:15,730
+بنحول أو يعني الأنواع الثمانية من التأثيرات، يا إما
+
+292
+00:30:15,730 --> 00:30:19,170
+الـMutation بتأثر على الـTranscription أو
+
+293
+00:30:19,170 --> 00:30:24,120
+Translation أو على الـFolding أو على الـ Post
+
+294
+00:30:24,120 --> 00:30:29,240
+-Translational Modification أو على الـAssembly of
+
+295
+00:30:29,240 --> 00:30:35,180
+the monomers into homomers أو الـSubcellular، يعني
+
+296
+00:30:35,180 --> 00:30:39,020
+الـMore Advanced Points about الـFunction of the
+
+297
+00:30:39,020 --> 00:30:43,700
+Protein، اللي هي الـSubcellular Localization أو
+
+298
+00:30:43,700 --> 00:30:47,900
+الـInteraction مع الـCo-Factor أو إنه يصير في
+
+299
+00:30:47,900 --> 00:30:53,940
+زيادة أو تغيير الـFunction بشكل مختلف تماماً كوظيفة
+
+300
+00:30:53,940 --> 00:30:58,960
+مثال على ذلك الـ Sickle Cell، راح نحكي عنه في
+
+301
+00:30:58,960 --> 00:31:05,020
+سؤال، تفضلي
+
+302
+00:31:05,020 --> 00:31:13,460
+يا سعاد، شو دكتور أحمد؟ خلي سعاد تحكي، الله عفوك يا
+
+303
+00:31:13,460 --> 00:31:18,350
+دكتور، الله عفوك، أول شيء بدي أسأله أنه إحنا حكينا
+
+304
+00:31:18,350 --> 00:31:22,190
+بما أنه فيه 70% من الـMutations الخاصة بالموضوع
+
+305
+00:31:22,190 --> 00:31:26,170
+هذا اللي هي الـHemoglobinopathies متعلقة بالـBlood
+
+306
+00:31:26,170 --> 00:31:28,670
+عشان هيك أنت الأمثلة اللي ضربتها كلها علاقة
+
+307
+00:31:28,670 --> 00:31:36,690
+بالـBlood، لأ، افهميني، إحنا اللي حكيناها إحنا
+
+308
+00:31:36,690 --> 00:31:44,370
+اليوم بدنا ندرس كيف الـMutation تتحول لـDisease،
+
+309
+00:31:44,370 --> 00:31:50,460
+ماشي؟ فالـ Chapter هذا بالذات المرة هذه مركزين على
+
+310
+00:31:50,460 --> 00:31:54,680
+الدم، والأمراض التانية والمشاكل التانية حاطينها في
+
+311
+00:31:54,680 --> 00:31:58,540
+الـ Chapter اللي راح نطلعه بعد، دكتورة، فبالنسبة
+
+312
+00:31:58,540 --> 00:32:04,300
+للدم، يعني مثلًا لو سألتي فصائل الدم، كم واحد، كم
+
+313
+00:32:04,300 --> 00:32:11,440
+نوع، إحنا اللي بتعرفوه الـ ABO و الـ Rh، صح؟ صح؟
+
+314
+00:32:11,440 --> 00:32:15,900
+الشيء اللي بتعرفيه الغالب؟ في حوالي 600 نوع Blood
+
+315
+00:32:15,900 --> 00:32:21,980
+Groups، في 600 نوع من الـ Blood Groups،  دولة الأشياء
+
+316
+00:32:21,980 --> 00:32:25,820
+اللي بنسميه Blood Group، لسه في أنواع كثيرة، وكل
+
+317
+00:32:25,820 --> 00:32:30,820
+واحد يمكن أشياء نادرة جدًا، بس موجودة في هذه الكتب
+
+318
+00:32:30,820 --> 00:32:34,280
+وإذا الواحد بده يتعامل مع المرضى والناس والمجتمع
+
+319
+00:32:34,280 --> 00:32:37,640
+بده يكون هيك على انتباهه أنه فيه شيء اسمه Blood
+
+320
+00:32:37,640 --> 00:32:42,740
+Groups مختلفة، الآن أنواع الـ Hemoglobinopathies
+
+321
+00:32:43,540 --> 00:32:52,060
+كـGenetic Diseases، كأمراض دم وراثية، مش أمراض دم من
+
+322
+00:32:52,060 --> 00:32:58,180
+أنواع تانية، يعني نتيجة Cancer، نتيجة Nutritional
+
+323
+00:32:58,180 --> 00:33:02,480
+Deficiency، نتيجة Autoimmune Disease، مش
+
+324
+00:33:02,480 --> 00:33:06,240
+الـPathologies التانية، إحنا بنحكي الـGenetic الآن
+
+325
+00:33:06,240 --> 00:33:10,360
+بنسميهم زي ما حكينا فيه Quantitative
+
+326
+00:33:10,360 --> 00:33:13,120
+وQualitative
+
+327
+00:33:13,410 --> 00:33:19,410
+Blood Disease، فالآن الـ من يعني الآن حتى لما نقول
+
+328
+00:33:19,410 --> 00:33:23,830
+ثلاسيميا أو Sickle Cell، هدولة Big Groups ولهن
+
+329
+00:33:23,830 --> 00:33:29,690
+أشكال وأنواع وأنواع، وفي لسه في أنواع أمراض Under
+
+330
+00:33:29,690 --> 00:33:35,210
+ومش مطلوب إنك تعرفها، بس على الـ level Tide
+
+331
+00:33:35,210 --> 00:33:40,110
+Folding، في سبعين Hemoglobinopathy تانية كمان
+
+332
+00:33:40,110 --> 00:33:48,040
+ما بدناش ندخل فيهم، بس كثير منهم لها علاقة بتلوي الـ
+
+333
+00:33:48,040 --> 00:33:52,340
+«Globin Polypeptide Chain»، اللي هو الـ «Folding»
+
+334
+00:33:52,340 --> 00:33:57,120
+أغلبها كان «Folding»، آه، ماشي، طيب، دكتور، إحنا
+
+335
+00:33:57,120 --> 00:34:00,140
+مطلوب مثلاً معناها نعرف أنه نوع من الـ «ثلاسيميا» هو
+
+336
+00:34:00,140 --> 00:34:03,400
+اللي بيعمل الـ هو اللي بيكون سبب الـ «Mutation» أو
+
+337
+00:34:03,400 --> 00:34:07,320
+اللي جعله «ثلاسيميا»، مطالبين بإيش؟ إذا شغل، ما أنت
+
+338
+00:34:07,320 --> 00:34:11,810
+بترجع تسألي، إسألي إن أنتِ كنتِ مش فاهمة شيء، أما إذا
+
+339
+00:34:11,810 --> 00:34:17,910
+مطلوبين أو مش مطالبين للامتحانات، ماشي؟ يعني الإنسان
+
+340
+00:34:17,910 --> 00:34:22,810
+إذا الواحد طبيب وإن شاء الله بس تخلصي تنطلقي في هذه
+
+341
+00:34:22,810 --> 00:34:28,690
+الحياة، وتشوف ناس وتشوف تعالجي، وبدك تصيري تسوي كل ما
+
+342
+00:34:28,690 --> 00:34:33,680
+الواحد يكون عنده فهم أحسن، بتكوني أنتِ دكتورة أفضل، بتقدري
+
+343
+00:34:33,680 --> 00:34:39,420
+تعالجي أفضل، بتنتبهي للأشياء، التداخلات مع بعض، أما
+
+344
+00:34:39,420 --> 00:34:45,920
+الأساس، مطلوب، مش مطلوب، يعني أنا كمعلومة أنه فيه 70
+
+345
+00:34:45,920 --> 00:34:52,200
+مرتبطة بهذه، آه جيد، الواحد يمكن يشوف حالة وبعدين
+
+346
+00:34:52,200 --> 00:34:59,290
+يجي يفحص مثلًا mutation في الـDNA ما يلاقيهاش، بس
+
+347
+00:34:59,290 --> 00:35:03,230
+الحالة وراثية، يعني العيلة مصابة وما فيش غيرهم
+
+348
+00:35:03,230 --> 00:35:09,950
+مصابين وبشكل معين، ممكن يكون جزء من الأنواع الأندر
+
+349
+00:35:09,950 --> 00:35:14,970
+اللي مختلفة، فأنا ما بطلب منكم ترجعوا على الـ
+
+350
+00:35:14,970 --> 00:35:21,350
+Mendelian Inheritance in Man Database  بالـ PubMed
+
+351
+00:35:21,350 --> 00:35:26,430
+وأقول لك روح دور لي شو هم، ولا شو أنواعهم، لأ، لأ،
+
+352
+00:35:26,430 --> 00:35:30,910
+شغلي نادر جدًا، بدّه الواحد دائمًا يفهم الـBiggest
+
+353
+00:35:30,910 --> 00:35:37,050
+Principles، المبادئ الأكبر، يعني، ماشي؟ فلا تسألي
+
+354
+00:35:37,050 --> 00:35:40,990
+مطلوب ولا مش مطلوب، إذا في شيء مش واضح، يعني هدول
+
+355
+00:35:40,990 --> 00:35:45,110
+السبعين اللي بيحكوا عنهم، يمكن في الدنيا كلها، كل
+
+356
+00:35:45,110 --> 00:35:49,690
+واحد منهم بيتكلم عن حالة، حالتين، أسرة، أسرتين، لقوة
+
+357
+00:35:49,690 --> 00:35:52,930
+ما يجي، في كذا، في كذا، في كذا، وراح نضرب أمثلة
+
+358
+00:35:52,930 --> 00:36:02,940
+عليهم، يعني على أشياء، في أسئلة؟ في شيء مش واضح كمان؟
+
+359
+00:36:02,940 --> 00:36:10,780
+طيب، بالنسبة
+
+360
+00:36:10,780 --> 00:36:20,920
+لكِ مبدأ آخر، ماشي؟ اللي هي قضية أنه يعني هيك الواحد
+
+361
+00:36:20,920 --> 00:36:28,000
+يفهمها فهم أنه أحيانًا الـ Diseases هي نتيجة
+
+362
+00:36:28,000 --> 00:36:35,120
+Allelic Heterogeneity أو Locus Heterogeneity، يعني
+
+363
+00:36:35,120 --> 00:36:38,940
+هنا بالذات،
+
+364
+00:36:38,940 --> 00:36:43,920
+يعني دخلت بالنسبة للـ Hemoglobinopathies بالذات،
+
+365
+00:36:43,920 --> 00:36:55,040
+ماشي؟ قضية اللي هي إنه بالنسبة لمثلًا الـ الـ Beta
+
+366
+00:36:55,040 --> 00:36:59,320
+-thalassemia أو بلاش الـ Sickle Cell Anemia، إذا
+
+367
+00:36:59,320 --> 00:37:04,280
+بتتذكري يعني فيه الـ Hemoglobin الطبيعي، الـ Beta
+
+368
+00:37:04,280 --> 00:37:12,180
+-Chain، وفيه الـ Abnormal، فيه واحد آه، مثلًا الـ
+
+369
+00:37:12,180 --> 00:37:15,420
+Hemoglobin A، هذا هو الـ Normal، والـ S Hemoglobin
+
+370
+00:37:15,420 --> 00:37:19,780
+هو الـ Abnormal، وبالتالي فيه هنا بيسموه الـ
+
+371
+00:37:19,780 --> 00:37:26,060
+Allelic Heterogeneity، بس أحيانًا راح نلاقي إنه فيه
+
+372
+00:37:26,060 --> 00:37:34,120
+Alpha-1 وAlpha-2 مثلًا، في مرات في نفس الـ Protein
+
+373
+00:37:34,120 --> 00:37:37,840
+زي الـ Hemoglobin، لأنه Alpha و Beta-Chain، في تداخل
+
+374
+00:37:37,840 --> 00:37:43,560
+بين أكثر من Locus، بحيث إنه شيء معين بيكون أشد
+
+375
+00:37:43,560 --> 00:37:48,500
+أكثر من سبب للمرض، وشيء معين بيكون أخف وأحسن
+
+376
+00:37:48,500 --> 00:37:56,040
+للمرض، فأحيانًا إذا بتدخل أكثر من الـ locus، طبعًا كل
+
+377
+00:37:56,040 --> 00:38:01,420
+الـ locus إله قليل إله بدائل، بحيث إنه البدائل
+
+378
+00:38:01,420 --> 00:38:06,880
+الموجودة تتدخل في قضية الـ genetic heterogeneity
+
+379
+00:38:06,880 --> 00:38:15,520
+الآن هذا مستوى من التعقيد والاختلافات، إنه يكون
+
+380
+00:38:15,520 --> 00:38:21,440
+عنده كل قليل مختلف، كل الجين نفسه كـ DNA فيه
+
+381
+00:38:21,440 --> 00:38:27,160
+اختلافات، بس أحيانًا الـ الـHeterogeneity
+
+382
+00:38:27,160 --> 00:38:31,780
+Phenotypic، يعني اللي أتكلمنا على الـPenetrance
+
+383
+00:38:31,780 --> 00:38:38,280
+أتكلمنا على Other Modifications، بحيث أنه أحيانًا
+
+384
+00:38:38,280 --> 00:38:45,480
+نفس الجين أو نفس الـLocus، بس بيصير عندي Variation
+
+385
+00:38:45,480 --> 00:38:49,880
+في الـPhenotype اللي أنا بشوفه، فهي مبدأ يعني أنا
+
+386
+00:38:49,880 --> 00:38:57,520
+بعتبر إنه تكرار لإيش قديم أخذناه بالنسبة لـ
+
+387
+00:38:57,520 --> 00:39:04,480
+Structure of the hemoglobin subunit، يكون هذه ناحية
+
+388
+00:39:04,480 --> 00:39:13,300
+مهمة كثيرة، الآن هذه الصورة هي three-dimensional
+
+389
+00:39:13,300 --> 00:39:20,600
+structure لـ الـ One Hemoglobin Unit، فما بدك
+
+390
+00:39:20,600 --> 00:39:25,640
+تتذكروا إنه الـ Hemoglobin، الصبغة الحمراء اللي في
+
+391
+00:39:25,640 --> 00:39:29,800
+الدم اللي بتعطي اللون الدم الأحمر، وظيفتها حمل
+
+392
+00:39:29,800 --> 00:39:37,980
+الأكسجين، عبارة عن أربع Globin Units، الأربع Globin
+
+393
+00:39:37,980 --> 00:39:45,900
+Units، Two Alphas وTwo Betas، الـ Globin يعني شيء
+
+394
+00:39:45,900 --> 00:39:54,830
+كروي، يعني شيء Globular، بشكل زي الكرة زي الـ球 يعني
+
+395
+00:39:54,830 --> 00:39:59,030
+مجموعة، طبعًا زي الـ Immunoglobulin أو الـ
+
+396
+00:39:59,03
+
+445
+00:45:07,770 --> 00:45:12,930
+genes في عندي Alpha-1 و Alpha-2 في عندي الـ Eta
+
+446
+00:45:12,930 --> 00:45:23,890
+هذه الـ أو Zeta أقل Zeta حرف يوناني أو من الأحرف
+
+447
+00:45:23,890 --> 00:45:30,610
+القديمة و أظن Zeta الآن
+
+448
+00:45:58,330 --> 00:45:59,730
+بالنسبة
+
+449
+00:45:59,730 --> 00:46:01,130
+لـ
+
+450
+00:46:02,050 --> 00:46:08,990
+والـ Alpha هي جزء من الـ Hemoglobin، الـ Beta هي
+
+451
+00:46:08,990 --> 00:46:16,910
+عندي خمسة وواحدة Beta رئيسية، وهنا Epsilon وGamma
+
+452
+00:46:16,910 --> 00:46:25,970
+Delta وA Delta، وأسف Gamma، G Gamma، وA Gamma، وI
+
+453
+00:46:25,970 --> 00:46:30,690
+Delta يعني
+
+454
+00:46:31,760 --> 00:46:40,820
+النقطة هذه ماشية، بدي الواحد يعني يربطها بالجدول
+
+455
+00:46:40,820 --> 00:46:48,440
+اللي تحت، يعني الـHemoglobin في حياة الإنسان لما
+
+456
+00:46:48,440 --> 00:46:55,100
+نتكلم على مراحله، الـEmpirionic Period، الـEarly
+
+457
+00:46:55,100 --> 00:47:01,700
+Empirionic Period، بعدين الـFetal Life، بعدين الـ
+
+458
+00:47:01,700 --> 00:47:08,760
+Adult Life أو الـ Later Life، الـ Life الحياة بعدين
+
+459
+00:47:08,760 --> 00:47:15,680
+لازم يكون الـ Hemoglobin اللي بتكون عندي مختلف في
+
+460
+00:47:15,680 --> 00:47:25,300
+كل مرحلة، السبب واضح، يعني السبب أنه أنا لما أكون في
+
+461
+00:47:25,300 --> 00:47:32,430
+بطن أمي وأنا جنين، الـ Lungs ما عندي Lungs، ما عندي
+
+462
+00:47:32,430 --> 00:47:38,230
+شيء يأخذ الـ Oxygen من الهوى أو من المي كسمكة ولا
+
+463
+00:47:38,230 --> 00:47:43,450
+شيء، الـ Hemoglobin اللي أنا بدي أخده الـ Acid الـ
+
+464
+00:47:43,450 --> 00:47:46,710
+Oxygen اللي بدي أخده في حالة الـ embryonic period
+
+465
+00:47:46,710 --> 00:47:52,510
+أو الـ fetal period بيجي من وين؟ بيجي من الأم، بيجي
+
+466
+00:47:52,510 --> 00:47:57,870
+من الـ placenta، اللي بيصير فيها إنه
+
+467
+00:47:57,870 --> 00:48:05,760
+بيقترب دم الجنين مع دم الأم، فإذا في المرحلة الجنينية
+
+468
+00:48:05,760 --> 00:48:14,040
+الـ Affinity اللي هي قوة استقطاب وتماسك أو مسك الـ
+
+469
+00:48:14,040 --> 00:48:21,260
+Hemoglobin للـ Oxygen متماثلة مع تبع الأم، النتيجة
+
+470
+00:48:21,260 --> 00:48:26,160
+راح تكون إنه أنا ما راح أقدر أخذ منها Oxygen كافي،
+
+471
+00:48:26,160 --> 00:48:32,570
+فبالتالي ما بيكون فيه Oxygen للجنين، فلازم حتى ينجح
+
+472
+00:48:32,570 --> 00:48:39,270
+الـ Oxygen تبع الجنين، أنه يأخذ الـ Oxygen عشان
+
+473
+00:48:39,270 --> 00:48:42,390
+ينجح، الـ Hemoglobin تبع الجنين أنه يمسك الـ Oxygen
+
+474
+00:48:42,390 --> 00:48:46,430
+من الـ Hemoglobin تبع الأم، لازم تكون الـ Affinity
+
+475
+00:48:46,430 --> 00:48:52,670
+تبعته للـ Oxygen أقوى من تبع الأم، فبالتالي إحنا في
+
+476
+00:48:52,670 --> 00:48:58,170
+عندنا أكثر من نوع من Hemoglobin، والأنواع اللي بتطلع
+
+477
+00:48:58,170 --> 00:49:03,690
+في كل مرحلة لازم تكون نوعية مختلفة، وبتكون بهذا
+
+478
+00:49:03,690 --> 00:49:10,630
+الشكل، في نقطة يعني أنا بتأكد أكيد مرت عليكم
+
+479
+00:49:10,630 --> 00:49:16,450
+بالنسبة للـElectrophoresis أو اللي هي تكون الدم إن
+
+480
+00:49:16,450 --> 00:49:20,030
+الخلايا اللي بتكون الدم، الـHematopoietic Stem Cell
+
+481
+00:49:20,030 --> 00:49:24,640
+والأشياء هذه، في المرحلة الأولى تبدأ في كيس الصفار
+
+482
+00:49:24,640 --> 00:49:29,440
+اللي هو الكيس اللي فيه الصفار اللي في البيض، بالله
+
+483
+00:49:29,440 --> 00:49:32,980
+فيه اللي هو ما يسمونه الـ Yolk sac، في مرحلة معينة من
+
+484
+00:49:32,980 --> 00:49:37,700
+حياة الجنين، الـ Embryonic، Early-Embryonic بتكون
+
+485
+00:49:37,700 --> 00:49:44,300
+الدم بتكون في الـ Yolk sac، بعدين later these cells
+
+486
+00:49:44,300 --> 00:49:48,960
+migrate into the liver وSpleen، وكونهم المصدر
+
+487
+00:49:48,960 --> 00:49:54,130
+الأكبر، وراح نشوف إذا دخل في الأمراض إنه يظل زي في
+
+488
+00:49:54,130 --> 00:49:57,430
+الثلاسيميا، إنه يظل إنتاج الدم من الـ Liver و
+
+489
+00:49:57,430 --> 00:50:04,050
+الـSpleen، بس بالأخير عند الولادة وعادة في بقية
+
+490
+00:50:04,050 --> 00:50:11,250
+حياة الإنسان الدم بتتكون بالنخاع، فهذه المراحل
+
+491
+00:50:11,250 --> 00:50:19,940
+اللي من وين تطلع الدم من الإنسان، إذا شفنا أنواع
+
+492
+00:50:19,940 --> 00:50:26,160
+الدم اللي بيكون موجود، ماشي، في ملاحظة قريتها لأنه
+
+493
+00:50:26,160 --> 00:50:31,960
+كنت أقرأ بالأمس، إنه بالنسبة للـ Alpha والـ Beta
+
+494
+00:50:31,960 --> 00:50:37,820
+-Genes، عادة من الـEmpirionic أو Early Empirionic
+
+495
+00:50:37,820 --> 00:50:45,020
+للـFetal، للأدلة الـ Transcription بيكون بالأول
+
+496
+00:50:45,020 --> 00:50:48,860
+بيستخدم النوع الأول، بعدين بيصير يستخدم النوع
+
+497
+00:50:48,860 --> 00:50:53,140
+الثاني أو الثالث اللي بتتبدل مع بعض، بس بالنسبة للـ
+
+498
+00:50:53,140 --> 00:50:58,460
+Beta Chain بيبدأ نوع معين، بعدين بيصير لنوع ثاني و
+
+499
+00:50:58,460 --> 00:51:05,680
+النوع الثاني بعدين بتحول لنوع ثالث، ماشي؟ يعني
+
+500
+00:51:05,680 --> 00:51:13,980
+إحنا المهم، يعني اللي بدك تذكره أنه إحنا بشكل
+
+501
+00:51:13,980 --> 00:51:21,200
+طبيعي كأفراد 95% أو أكثر Hemoglobin A اللي هو Alpha
+
+502
+00:51:21,200 --> 00:51:29,800
+2 Beta 2، إحنا هذا تبعنا كأفراد، فيه 3، 4، 5% اللي هو
+
+503
+00:51:29,800 --> 00:51:38,890
+A2 اللي هو Alpha 2 Delta 2، بهذا الشكل، ماشي؟ في
+
+504
+00:51:38,890 --> 00:51:43,750
+الحالة اللي حكيناها اللي هي الـ Persistence of
+
+505
+00:51:43,750 --> 00:51:49,330
+Hemoglobin F، الـ Hemoglobin F هي Alpha 2 Gamma 2
+
+506
+00:51:49,330 --> 00:51:56,330
+نوع ثاني من الـ Beta Chain، ماشي، هدول الثلاثة اللي
+
+507
+00:51:56,330 --> 00:52:01,810
+بدي أقول Gower 1 و Gower 2 و Portland، يعني Early
+
+508
+00:52:01,810 --> 00:52:06,130
+Empyrionic Period، اللي قصدي في الموضوع إنه كل ما
+
+509
+00:52:06,130 --> 00:52:11,830
+نمشي من هون لهون، الـ Affinity للـ Oxygen بتقل، يعني
+
+510
+00:52:11,830 --> 00:52:16,370
+هذا very strongly associated with، يعني مرتبط بالـ
+
+511
+00:52:16,370 --> 00:52:20,490
+Oxygen قوي كتير، حتى يقدر يخضع من الـ Ohm، وبعدين
+
+512
+00:52:20,490 --> 00:52:27,110
+هنا أحسن شوية أو أخف شوية، بس لسه أحسن من الـ A1 أو
+
+513
+00:52:27,110 --> 00:52:33,570
+الـ A و الـ A2، هنا ما فيش A1، حاطين A و A2، نلتزم زي
+
+514
+00:52:33,570 --> 00:52:41,030
+ما هم حاكيين، فالخلاصة تبع الموضوع هذا إنه أنا
+
+515
+00:52:41,030 --> 00:52:45,010
+بالنسبة للـ Hemoglobin Molecule في عندي Alpha
+
+516
+00:52:45,010 --> 00:52:51,130
+Chain و Beta Chain، اثنتين اثنتين، كل واحد فيها هيم
+
+517
+00:52:51,130 --> 00:52:57,050
+هذا الـFull Hemoglobin اللي عندي، يعني في اللي
+
+518
+00:52:57,050 --> 00:53:07,230
+بيشترك ضمن، يعني إذا بنشوف الـ… الجدول الأخير، ماشي،
+
+519
+00:53:07,230 --> 00:53:13,490
+في الـ Empyrionic Period بالنسبة لـ، بالأول ببدأ
+
+520
+00:53:13,490 --> 00:53:18,710
+يعني حتى بفترة مبكرة الـ Alpha Chain بيكون هو الـ
+
+521
+00:53:18,710 --> 00:53:23,230
+dominant، وطبعاً دي Alpha 1 و Alpha 2، ويكون موجود
+
+522
+00:53:23,230 --> 00:53:26,890
+يمكن نسبة شوية مختلفة ولا كده، بس اللي هي الـ Alpha
+
+523
+00:53:26,890 --> 00:53:31,330
+Chain، وإنه في الـ Empyrionic Period في إيش اسمه
+
+524
+00:53:31,330 --> 00:53:35,920
+بالنسبة للـ Beta Chain في اسمها الـ Gamma Chain، الـ
+
+525
+00:53:35,920 --> 00:53:39,400
+Gamma Chain هي بديل عن الـ Beta Chain، ولما
+
+526
+00:53:39,400 --> 00:53:43,980
+الإنسان يولد يصير switch في حياته إنه بيبطل يطلع
+
+527
+00:53:43,980 --> 00:53:48,120
+الـ F-Hemoglobin، يصير يطلع الـ Alpha الـ A
+
+528
+00:53:48,120 --> 00:53:53,380
+-Hemoglobin، والـ Gamma
+
+529
+00:53:53,380 --> 00:54:02,780
+بيبطل يطلع، ماشي، لحد معين بنلاقي الـ Gamma صار ينزل
+
+530
+00:54:02,780 --> 00:54:08,040
+وإذا ظل موجود يبقى راح يا إما يعمل مشكلة أو
+
+531
+00:54:08,040 --> 00:54:12,100
+يُحسّن المشكلة ثانية، راح نهتم يعني، وفيه عندنا
+
+532
+00:54:12,100 --> 00:54:18,300
+بالنسبة بسيطة جداً، 5، 2، 3، 4% بدل الـBeta Chain
+
+533
+00:54:18,300 --> 00:54:25,800
+فيه عندي الـDelta Chain اللي راح تعطيني الـA2، فأنا
+
+534
+00:54:25,800 --> 00:54:33,470
+بعتبر هذا الـSlide وهذا الجدول من أهم الجداول، وهذا
+
+535
+00:54:33,470 --> 00:54:37,410
+بدي إياكم تفهموا الـ Gower one و two و three أو
+
+536
+00:54:37,410 --> 00:54:41,690
+Portland والأشياء هذه ما بدي إياها، هي مش مهمة، بس
+
+537
+00:54:41,690 --> 00:54:49,170
+علاقات الـ F والـ A2 والـ A والأنواع المختلفة و
+
+538
+00:54:49,170 --> 00:54:54,170
+كيف بتيجي وكيف تطورها في حياة الإنسان، أنا
+
+539
+00:54:54,170 --> 00:54:58,890
+بعتبر هذه أهم الجوانب، ولازم الواحد يكون مذكرها و
+
+540
+00:54:58,890 --> 00:54:59,610
+فاهمها
+
+541
+00:55:03,130 --> 00:55:10,530
+هذه هي الـ Genetic Basis، وهنا الناس، يعني We are
+
+542
+00:55:10,530 --> 00:55:16,230
+describing the normal development of Hemoglobin
+
+543
+00:55:16,230 --> 00:55:23,830
+production، بيكون على مراحل مختلفة، لأنواع مختلفة،
+
+544
+00:55:23,830 --> 00:55:31,740
+بجينات مختلفة، واللي بنبه عليه أنه يعني تركيب، كأنه
+
+545
+00:55:31,740 --> 00:55:36,540
+فيه حاجة Controller بمرحلة معينة بيخلي هذا النوع
+
+546
+00:55:36,540 --> 00:55:40,120
+يطلع، بعد شوية اللي بعده، وبعد شوية اللي بعده
+
+547
+00:55:40,120 --> 00:55:45,320
+بالنسبة للـ Beta-Chain، النوع الأول بشكل معين، بعدين
+
+548
+00:55:45,320 --> 00:55:49,040
+النوع الثاني، وبعدين النوع الثالث، بهذا الشكل، يعني
+
+549
+00:55:49,040 --> 00:55:54,440
+أن الأصل أنه في كل مرحلة بتلاقي نوعية معينة من
+
+550
+00:55:54,440 --> 00:55:58,610
+الـHemoglobin لازم تطلع، وبعدين بس يخلص وبنتقل على
+
+551
+00:55:58,610 --> 00:56:03,130
+النوع اللي بعدها، حسب الاحتياج، وحسب الوضع، وحسب حياة
+
+552
+00:56:03,130 --> 00:56:08,990
+الإنسان، سبحان الله، تفاصيل
+
+553
+00:56:08,990 --> 00:56:16,070
+الـ Beta المعقدة أكثر، وبالذات أنواع الـ Genetic
+
+554
+00:56:16,070 --> 00:56:24,050
+Mutation، حكينا عنها، بالنسبة
+
+555
+00:56:24,050 --> 00:56:31,880
+لـ، يعني للـ Hemoglobin، بذكر مرة ثالثة لما نقول
+
+556
+00:56:31,880 --> 00:56:39,780
+Hemoglobinopathy، يا إما نوعية نعتبرها اللي هي
+
+557
+00:56:39,780 --> 00:56:46,500
+Quantitative، وفي Qualitative، فالـ Qualitative ماشي
+
+558
+00:56:46,500 --> 00:56:54,800
+اللي هي إنه شكل الـ Hemoglobin اختلف، ما هم نتكلم
+
+559
+00:56:54,800 --> 00:57:00,240
+على بروتين طبيعي وكميته اختلفت، لأ، هنا إنه صار فيه
+
+560
+00:57:00,240 --> 00:57:08,860
+شيء عمل مشكلة، أهم نوع الـ Hemoglobin-S اللي هو
+
+561
+00:57:08,860 --> 00:57:12,820
+بيعطينا Sickle Cell Disease، Sickle Cell Disease
+
+562
+00:57:12,820 --> 00:57:18,040
+الـHemoglobin اللي فيه بيسموه Hemoglobin-S، وهي
+
+563
+00:57:18,040 --> 00:57:25,560
+Autosomal Recessive، اللي بيصير إنه في الـ، يعني لازم
+
+564
+00:57:25,560 --> 00:57:31,440
+واحد يكون يقدر يقرا هذه الـ Notation اللي هي إن
+
+565
+00:57:31,440 --> 00:57:40,060
+الـ Beta Chain، الـ Position رقم 6 في الـ Glutamine
+
+566
+00:57:40,060 --> 00:57:44,300
+أظن أن الـ Amino Acid Glutamine بتتحول لـ Valine
+
+567
+00:57:44,300 --> 00:57:49,420
+فهي Amino Acid Substitution، وهي لما نكتب لكم
+
+568
+00:57:49,420 --> 00:57:54,010
+الأرقام هذه، الـ Glutamine position 26 صار Lysine
+
+569
+00:57:54,010 --> 00:58:00,970
+Asparagine، هذا position 99 صار ASM، يجب أن يقرأ أحد
+
+570
+00:58:00,970 --> 00:58:06,470
+ما هو الـ Amino Acid، نتيجة المشكلة هذه، فهذه الـ
+
+571
+00:58:06,470 --> 00:58:11,190
+notation لازم الواحد يعرفها
+
+572
+00:58:11,190 --> 00:58:20,640
+الـ Sickle Cell Disease عبارة عن، يعني كيف تبدأ
+
+573
+00:58:20,640 --> 00:58:26,000
+الأمر من الـGenetics
+
+574
+00:58:26,000 --> 00:58:31,280
+لـDisease Phenotype، لشو اللي بنشوفه على المريض
+
+575
+00:58:31,280 --> 00:58:34,620
+الـGenetic
+
+576
+00:58:34,620 --> 00:58:41,560
+Basis، إنه الـNormal Codon GAG فبتتحول لكودون GTG
+
+577
+00:58:41,560 --> 00:58:51,030
+كودون تبع GTG، بدل الـGAG، فالـ Glutamine الـ "جلوتاميك"
+
+578
+00:58:51,030 --> 00:58:56,030
+اتحول لـ "فالين"، هذا الـ "فالين" إذا بتتذكره
+
+579
+00:58:56,030 --> 00:59:03,050
+أظنه Hydrophobic، تحب تشيل مية، وهذا Hydrophilic
+
+580
+00:59:03,050 --> 00:59:09,510
+طبعاً، يعني سبحان الله، ليش الـ Folding بيصير بالشكل
+
+581
+00:59:09,510 --> 00:59:14,410
+هذا؟ إله دخل إنه لما يصير الـ Folding بشكل طبيعي
+
+582
+00:59:14,410 --> 00:59:20,280
+اللي على السطح لازم يكون Hydrophilic، يعني بيحب
+
+583
+00:59:20,280 --> 00:59:27,140
+الماية، واللي جوا بيكون Hydrophobic، لأنه بيكون لازم
+
+584
+00:59:27,140 --> 00:59:32,020
+يكره الماية حتى يظلوا جوا، ويكونوا جوا عشان ما يتعرضوش
+
+585
+00:59:32,020 --> 00:59:39,580
+للمية، فنتيجة الاختلال هذا من Hydrophilic على
+
+586
+00:59:39,580 --> 00:59:45,000
+Hydrophobic على position معين، تصير إنه
+
+587
+00:59:45,000 --> 00:59:50,310
+الـHemoglobin الـS، في حالة لما يكون Oxygenated
+
+588
+00:59:50,310 --> 00:59:54,830
+Hemoglobin في الـRed Blood Cell بتكون
+
+589
+00:59:54,830 --> 01:00:00,470
+الـHemoglobin Molecules متوزعة بالشكل الطبيعي، في
+
+590
+01:00:00,470 --> 01:00:06,330
+حالة الـDeoxyhemoglobin، ماشي، لما يبطل ويقل نسبة
+
+591
+01:00:06,330 --> 01:00:14,310
+الأكسجين، ويتحول إلى Deoxy، الـHydrophobic يعني
+
+592
+01:00:14,310 --> 01:00:20,740
+الـPatch، تخيل عند الكرة، الأصل الكرات بتضرب بعض،
+
+593
+01:00:20,740 --> 01:00:26,680
+وما يكونش فيها أي شيء، لأ، الكرة اتغيرت بحيث
+
+594
+01:00:26,680 --> 01:00:30,900
+أنه على قطعة منها أو على جانب معين صار شيء لزق،
+
+595
+01:00:30,900 --> 01:00:38,640
+صار شيء sticky، فلما يصير Deoxyhemoglobin، المنطقة
+
+596
+01:00:38,640 --> 01:00:43,060
+اللي بتلزق هذه بتبين أكثر وبتكون أكثر، وبنتج عنها
+
+597
+01:00:43,060 --> 01:00:50,220
+أنها بتتجمع في، يعني كريستال، يعني على شكل بلورة، هي
+
+598
+01:00:50,220 --> 01:01:05,280
+شيء كبير وشيء يعني صلب، فالأصل الخلية الـ Red blood
+
+599
+01:01:05,280 --> 01:01:09,660
+cells اللي هي Biconcave بهذا الشكل، easily
+
+600
+01:01:09,660 --> 01:01:15,270
+deformable، يعني تقدر تتلوى، تقدر تتغير في حالها
+
+601
+01:01:15,270 --> 01:01:21,110
+بحيث أنه تقدر تفوت في أماكن ضيقة، فلما يصير عندي
+
+602
+01:01:21,110 --> 01:01:27,330
+الشكل المنجلي اللي هو المنجل بهذا الشكل، نتيجة تكوين
+
+603
+01:01:27,330 --> 01:01:32,110
+crystals من الـHemoglobin-S، يصير عندي non
+
+604
+01:01:32,110 --> 01:01:37,600
+-deformability، بتبطل تقدر تتلوى، اللي بيصير عندي
+
+605
+01:01:37,600 --> 01:01:42,380
+بيصير vaso-occlusion، فبيصير عندي hemolysis جزء منه
+
+606
+01:01:42,380 --> 01:01:47,220
+وبيصير عندي سُدادة بالـ capillaries، بالشعيرات
+
+607
+01:01:47,220 --> 01:01:58,800
+الدموية، وهذا سبب أساسي في المرض، ناشي، بالنسبة
+
+608
+01:01:58,800 --> 01:02:05,430
+للـ hemoglobin، hemoglobinopathies اللي هم الـ
+
+609
+01:02:05,430 --> 01:02:13,070
+نتيجة الـ hemoglobinopathies، نتيجة الـ qualitative
+
+610
+01:02:13,070 --> 01:02:20,990
+qualitative، في عندي أكثر من نوع، بس ده يعني أنا إذا
+
+611
+01:02:20,990 --> 01:02:26,710
+بتذكر الـ hemoglobin S وتفاصيله بيكفي، في الـ
+
+612
+01:02:26,710 --> 01:02:33,350
+hemoglobin Hammersmith بيسوي Hemolysis، وبكون له
+
+613
+01:02:33,350 --> 01:02:38,500
+Oxygen Affinity بكون عندي "تغيير"، مختلف، "هيموجلوبين"
+
+614
+01:02:38,500 --> 01:02:44,420
+"هايبرد" أو "هيموجلوبين M" بيسمينه، بيكون عندي
+
+615
+01:02:44,420 --> 01:02:50,080
+"سيانوسس"، ماشي، أحد أسباب أن المريض عنده زرقة
+
+616
+01:02:50,080 --> 01:02:58,100
+"كمية"،
+
+667
+01:07:49,290 --> 01:07:52,670
+منطقة حوض البحر المتوسط في أفريقيا في
+
+668
+01:07:52,670 --> 01:07:57,510
+أماكن معينة وإما بتشوف فيه ملاريا كثيرة بتلاقي نسبة
+
+669
+01:07:57,510 --> 01:08:05,450
+الـHemoglobin S أكثر في ناس يعني في نظرية لكل واحد
+
+670
+01:08:05,450 --> 01:08:09,990
+دقيقة أن الـ S-Hemoglobin يعطي نوع من الـ
+
+671
+01:08:09,990 --> 01:08:16,090
+Resistance للملاريا، وفي يعني كلام على أنه لا، لأن
+
+672
+01:08:16,090 --> 01:08:20,830
+الـ Hemoglobin S المشكلة تبعته لما يكون
+
+673
+01:08:20,830 --> 01:08:26,030
+Deoxyhemoglobin S أما لما يكون Oxyhemoglobin S مش
+
+674
+01:08:26,030 --> 01:08:33,050
+مشكلة كثيرة، يعني أنه في المناطق المرتفعات
+
+675
+01:08:33,050 --> 01:08:36,950
+بيكون الأكسجين أقل واحتمالية الـDeoxygenation
+
+676
+01:08:36,950 --> 01:08:42,870
+أكبر، وبالتالي ما يكونش موجود بشكل، يعني فيه
+
+677
+01:08:42,870 --> 01:08:47,830
+selection، الإختيار الطبيعي، اللي هو الـNatural
+
+678
+01:08:47,830 --> 01:08:52,990
+Selection اللي بعتبره يعني بديل عن، أو جزء من
+
+679
+01:08:52,990 --> 01:08:59,500
+التفسير ليش الأمور تمشي بهذا الشكل. في عندي أكثر من
+
+680
+01:08:59,500 --> 01:09:07,600
+نوع، وعندي هدول مشاكل بسميهم نتيجة الـHemoglobin
+
+681
+01:09:07,600 --> 01:09:14,220
+ممكن الـHemoglobin S، فيه Hemoglobin SC، الـC-
+
+682
+01:09:14,220 --> 01:09:19,160
+Hemoglobin نوع، لسه آخر. على عكس المرضى بيكونوا
+
+683
+01:09:19,160 --> 01:09:24,140
+كويسين إذا فيه Persistence of F-Hemoglobin، يعني
+
+684
+01:09:24,140 --> 01:09:28,420
+سبحان الله، كل الأعراض اللي حكيناها للـS-Hemoglobin
+
+685
+01:09:28,420 --> 01:09:33,420
+لما نكون مع الـA بس. إذا فيه F، وزيادة شوية في الـF
+
+686
+01:09:33,420 --> 01:09:41,440
+الـS بيبطل يسبب مرض، يعني في علاقات مع بعض. فجزء من
+
+687
+01:09:41,440 --> 01:09:47,220
+الظواهر، الـPersistence of Elevated Fetal
+
+688
+01:09:47,220 --> 01:09:52,640
+Hemoglobin Expression. يعني في حالات، بدل حتى بعد ما
+
+689
+01:09:52,640 --> 01:09:56,700
+نولد، والأصل أن الـF-Hemoglobin يبطل ويتحول للـA-
+
+690
+01:09:56,700 --> 01:10:03,320
+Hemoglobin، وبعد شوية يطلع الـA2. هذه ممكن إنها إذا
+
+691
+01:10:03,320 --> 01:10:06,820
+في ظل زيادة أو ارتفاع الـF-Hemoglobin،
+
+692
+01:10:06,820 --> 01:10:10,880
+الـPolymerization، الـCrystallization تبع الـS-
+
+693
+01:10:10,880 --> 01:10:21,520
+Hemoglobin بتقل. أحسن بالنسبة للـ «سكلر»، ويعني
+
+694
+01:10:21,520 --> 01:10:27,940
+الكلام اللي بحكوه عنه. إذا بحطه مثال على أنه الأصل
+
+695
+01:10:27,940 --> 01:10:30,700
+اللي الواحد يشوف الـFetal Hemoglobin يمشي بهذا
+
+696
+01:10:30,700 --> 01:10:35,300
+الشكل، بالذات بعد الولادة، بتلاقي أنه فيه persistence
+
+697
+01:10:35,300 --> 01:10:41,560
+of F-Hemoglobin، ويكون نتيجة هنا إختلال على مستوى
+
+698
+01:10:41,560 --> 01:10:51,570
+الـRNA level. يعني إشي مش بالضرورة مربوط بالـ…
+
+699
+01:10:51,570 --> 01:10:58,230
+مربوط بالـ… يعني الـCoding DNA، Anomaly مش Coding
+
+700
+01:10:58,230 --> 01:11:05,610
+DNA. هنا على إشي في الـcontrol على الـDNA
+
+701
+01:11:05,610 --> 01:11:10,650
+Expression. ماشي؟ ففي عندنا Persistence of Fetal
+
+702
+01:11:10,650 --> 01:11:17,240
+Hemoglobin، وهذا يعني إله تأثيرات معينة الآن
+
+703
+01:11:17,240 --> 01:11:22,740
+السعيدة،
+
+704
+01:11:22,740 --> 01:11:27,400
+أه، أحكي فالينا قبل ما ندخل على التلاسيميا هي هيك
+
+705
+01:11:27,400 --> 01:11:34,200
+حكيت النقاط اللي بدي إياها بالنسبة للـ Sickle Cell أو
+
+706
+01:11:37,110 --> 01:11:41,730
+qualitative، في فرط الـquality، hemoglobin-based،
+
+707
+01:11:41,730 --> 01:11:46,510
+آية سعيدة دكتور، في جزئيتي لما حكيت أنه في المرتفعات
+
+708
+01:11:46,510 --> 01:11:50,150
+بيصير احتمالية أن يصير الـdeoxygenation أكثر وأن
+
+709
+01:11:50,150 --> 01:11:53,490
+أنا المشكلة عندي في الـsickle cell anemia، اللي
+
+710
+01:11:53,490 --> 01:11:56,410
+بالـsickle cell أنه يكون عندي وجود الـhemoglobin
+
+711
+01:11:56,410 --> 01:12:00,870
+acid اللي هو في هيئة الـdeoxy، نعم، لأن هو اللي
+
+712
+01:12:00,870 --> 01:12:05,430
+بيكون هو اللي بيعمل الـcrystals، و… صحيح، ما فهمتش
+
+713
+01:12:05,430 --> 01:12:08,730
+أنا إيش بقى بيصير احتمالية الـDX ينقص، الـDX ينقص؟
+
+714
+01:12:08,730 --> 01:12:14,410
+لا، يعني معناته أن اللي عنده هاي الـSickles
+
+715
+01:12:14,410 --> 01:12:18,230
+الـHemoglobin بيروحش يعيش على المرتفعات العالية،
+
+716
+01:12:18,230 --> 01:12:24,790
+يعني مناطق اللي على المرتفعات، يعني بيعيش في أشياء
+
+717
+01:12:24,790 --> 01:12:30,850
+على مستوى سطح البحر، يعني مثلًا تقول لي والله الناس
+
+718
+01:12:30,850 --> 01:12:36,180
+اللي عايشين على الـHimalayas، في حد عنده سكل سيل
+
+719
+01:12:36,180 --> 01:12:42,640
+هناك؟ لما أروح أدرسهم بلاقي قليل جدًا لأنه ما فيش حد
+
+720
+01:12:42,640 --> 01:12:49,460
+يعني عنده سكل، ويعني كأنه صار بين قوسين، يعني هذه من
+
+721
+01:12:49,460 --> 01:12:53,870
+الظواهر اللي الواحد بينتبه لها، الإنتخاب الطبيعي،
+
+722
+01:12:53,870 --> 01:12:59,770
+يعني نتيجة أن الإنسان عنده مِلْعة، يعني زي ما تقولي
+
+723
+01:12:59,770 --> 01:13:03,810
+اللون
+
+724
+01:13:03,810 --> 01:13:09,730
+الأسمر، أو الجلد الأسمر، أكثر من الشمس، فعشان هيك
+
+725
+01:13:09,730 --> 01:13:14,930
+السمار في أفريقيا حوالين خط الاستواء، في القطبين
+
+726
+01:13:14,930 --> 01:13:20,080
+ما فيش حد أسمر، شكل طبيعي، بيروح كثير. فاهمي عليّ؟ وإذا
+
+727
+01:13:20,080 --> 01:13:24,880
+أبيض وراح على خط الاستواء مثلًا، بتلاقي صابه أمراض
+
+728
+01:13:24,880 --> 01:13:32,020
+زي مثلًا cancer of the skin، أو بيصير عنده أشياء،
+
+729
+01:13:32,020 --> 01:13:39,080
+شو اسمه؟ ما بيقدرش يعمل adaptation، ما بيقدرش يعمل
+
+730
+01:13:39,080 --> 01:13:42,620
+adaptation، يعني، أه لا، يعني راح يسبب له مرض، فعلى
+
+731
+01:13:42,620 --> 01:13:51,700
+مدى أجيال، على مدى، يعني مدى طويل، قبل السفر
+
+732
+01:13:51,700 --> 01:13:57,020
+الطويل، وقبل الطب المتقدم والأشياء هذه، يعني اللي
+
+733
+01:13:57,020 --> 01:14:03,080
+بيكون عنده، cycling، يعني إذا في مرض للـ carrier،
+
+734
+01:14:03,080 --> 01:14:11,220
+ماشي، بيقولوا أنه مع الـ fever بيسيبهم hematuria،
+
+735
+01:14:11,220 --> 01:14:16,460
+يعني بيصير عندهم Crystallization بالـ Hemoglobin
+
+736
+01:14:16,460 --> 01:14:21,160
+للـ Carrier، مش اللي عنده Disease، في الـ Tubules of
+
+737
+01:14:21,160 --> 01:14:25,600
+the kidneys، لما يكون عندهم Infection ولا كده، لأنه
+
+738
+01:14:25,600 --> 01:14:29,960
+نسبة الأكسجين قليلة كثير، فنسبة الـ
+
+739
+01:14:29,960 --> 01:14:33,580
+Crystallization أكثر في هذا المكان في هذا الوقت،
+
+740
+01:14:33,580 --> 01:14:39,840
+بسبب لهم مظهر معين، أنه بيصير عندهم مرض، آه آه
+
+741
+01:14:42,200 --> 01:14:51,780
+هي كتابة من القرآن، الله يعطيك، الله، الآن الموضوع
+
+742
+01:14:51,780 --> 01:15:02,480
+الثاني، بدنا نتذكر أن، يعني المبدأ الثاني اللي هو
+
+743
+01:15:02,480 --> 01:15:08,840
+أن إذا عندي مشكلة في عدد وكمية Normal Alpha أو
+
+744
+01:15:08,840 --> 01:15:16,670
+Beta Chain، بدنا نسميه ثلاسيميا. فالـثلاسيميا هي لما يكون
+
+745
+01:15:16,670 --> 01:15:23,230
+عندي مش Qualitative، مش خلل في الـquality، لا، خلل
+
+746
+01:15:23,230 --> 01:15:28,350
+في الـquantity، ماشي؟ فالأنواع اللي حكيناها
+
+747
+01:15:28,350 --> 01:15:32,510
+للـBeta وده في Alpha، Beta، هدول يعني
+
+748
+01:15:32,510 --> 01:15:36,630
+الـHemoglobin Structural Variants. لاحظ أنا كلهم
+
+749
+01:15:36,630 --> 01:15:41,250
+Beta Chain، يعني مش حاطين مثال على Alpha Chain، يكون
+
+750
+01:15:41,250 --> 01:15:49,350
+فيها زي الـSickle، Qualitative. الفلسيفية
+
+751
+01:15:49,350 --> 01:15:54,930
+هي لما يكون عندي Abnormalities
+
+752
+01:15:54,930 --> 01:16:02,730
+in the level of the expression of Alpha وBeta
+
+753
+01:16:02,730 --> 01:16:08,110
+chain. فهم الـAlpha وBeta normal كـStructure per se
+
+754
+01:16:08,520 --> 01:16:14,080
+بس كعدد و Level فيه Abnormality. في عندنا الـ
+
+755
+01:16:14,080 --> 01:16:20,880
+«ثلاسيميا». بنقسمهم Alpha و Beta «ثلا». ثلاثة
+
+756
+01:16:20,880 --> 01:16:26,580
+«ثلاثة»، يعني البحر «يميا»، Blood، يعني كانوا
+
+757
+01:16:26,580 --> 01:16:31,520
+اليونانيين، أو كلمة من المصدر اليوناني لدم البحر،
+
+758
+01:16:31,520 --> 01:16:37,060
+يعني هيك بدنا نأخذها، ويكون يعني جزء منه كما ذكرت
+
+759
+01:16:37,440 --> 01:16:42,500
+الله العالم بفسره، ارتباطها بالـ Malaria، أو يمكن
+
+760
+01:16:42,500 --> 01:16:46,240
+بنقص الأكسجين، أو الأكسجين. ففي عندنا Beta
+
+761
+01:16:46,240 --> 01:16:52,380
+-thalassemia، وفي عندي Alpha-thalassemia، ماشي؟
+
+762
+01:16:52,380 --> 01:17:00,760
+في اللي لما نكون، في عندي إيش اسمه؟ لما نكون عندي
+
+763
+01:17:00,760 --> 01:17:05,120
+Beta-thalassemia، ماشي؟ ويكون عندي Excess of
+
+764
+01:17:05,120 --> 01:17:09,460
+Normal Alpha Chain. بسموه إيش؟ بنشوفه تحت الـ
+
+765
+01:17:09,460 --> 01:17:13,720
+Microscope، بسموه Heinz Bodies، يعني عبارة عن زي هيك
+
+766
+01:17:13,720 --> 01:17:23,700
+نقطة سوداء أكثر، أو غامقة أكثر في الـ بالنسبة للـ
+
+767
+01:17:23,700 --> 01:17:28,280
+زي الـ Beta-thalassemia الأكثر، اللي هم الـ Alpha
+
+768
+01:17:28,280 --> 01:17:36,510
+-thalassemia. الـ Alpha-thalassemia، هي هنا Simple
+
+769
+01:17:36,510 --> 01:17:45,590
+Beta-thalassemia. يعني هنا زي ما أنتم شايفين فيه
+
+770
+01:17:45,590 --> 01:17:50,110
+عندنا، يعني هنا حاطين الـAffected Population،
+
+771
+01:17:50,110 --> 01:17:55,910
+الـBlacks، الـIndians، الـMediterranean، منطقتنا،
+
+772
+01:17:55,910 --> 01:18:06,060
+الـAsians، اليابانيين. ففيه أكثر من نوع من الـ
+
+773
+01:18:06,060 --> 01:18:13,540
+Mechanism حتى يعطينا Beta-thalassemia. يعني الأكثر
+
+774
+01:18:13,540 --> 01:18:19,520
+أشياء، أن طبعًا، يعني الملاحظة كمان، نقطة لازم واحد
+
+775
+01:18:19,520 --> 01:18:25,820
+يكون منتبه إليها، أن ممكن عندي أنا Second cell
+
+776
+01:18:25,820 --> 01:18:30,100
+Beta-thalassemia ممكن يصير، أو Alpha-thalassemia،
+
+777
+01:18:30,590 --> 01:18:35,930
+فعشان هيك، يعني بتكون أنه فيه خللَين في نفس الوقت،
+
+778
+01:18:35,930 --> 01:18:40,570
+في خللَين مختلفَين. الـ Sickle Cell، S-Hemoglobin،
+
+779
+01:18:40,570 --> 01:18:46,950
+نتيجة Beta Chain Mutation في مكان معين لإشي معين،
+
+780
+01:18:46,950 --> 01:18:52,810
+هذا يعطينا الـ Beta-Thalassemia، الـSLS-Hemoglobin،
+
+781
+01:18:52,810 --> 01:18:58,150
+والـBeta-Thalassemia، في يعني
+
+782
+01:18:59,300 --> 01:19:05,040
+بالنسبة للـ Beta-thalassemia بشكل عام، أشياء مش
+
+783
+01:19:05,040 --> 01:19:10,220
+deletion، يعني إذا بتشوفوا شو أنواع المشاكل يعني،
+
+784
+01:19:10,220 --> 01:19:15,540
+أنا الشغلات المعقدة ما بدي أدخل فيها، أنا مش حافظها،
+
+785
+01:19:15,540 --> 01:19:20,560
+يعني، أو مش منتبه لها، شايف عليك؟ بس لاحظوا أهم نقطة،
+
+786
+01:19:20,560 --> 01:19:25,680
+أنها مش deletion اللي هي بتتوقعوها في الـAlpha
+
+787
+01:19:25,680 --> 01:19:35,240
+-thalassemia. الشغل الثاني، كنوع Specific للـ Defect،
+
+788
+01:19:35,240 --> 01:19:40,120
+في كل نوع من الـ Beta-thalassemia. هذا بيحطوا Beta
+
+789
+01:19:40,120 --> 01:19:46,140
+-thalassemia Plus، أو Beta Zero، Beta Zero، بيكون
+
+790
+01:19:46,140 --> 01:19:52,860
+more، يعني Severe in the manifestation، بيكون درجة
+
+791
+01:19:52,860 --> 01:19:57,680
+الأنيميا، درجة الخلل شديدة كثير. فبنكتب لكم Beta
+
+792
+01:19:57,680 --> 01:20:05,920
+Plus، بيكون أخف، وفي مجال أحسن، يعني المريض بيعيش
+
+793
+01:20:05,920 --> 01:20:09,600
+أحسن، يعني أو بيكون الـHemoglobin تبعه أحسن، أو
+
+794
+01:20:09,600 --> 01:20:15,140
+بعضها almost، يعني almost reaching normal، ماشي؟
+
+795
+01:20:15,140 --> 01:20:21,040
+فهذول يعني بالنسبة للـBeta-thalassemia، ممكن يجيء
+
+796
+01:20:21,040 --> 01:20:25,420
+مع الـsickle cell، ممكن واحد مصاب بالـSC Hemoglobin،
+
+797
+01:20:25,840 --> 01:20:31,660
+والثانية فيها ثلاسيميا، بشكل اللي هو يؤثر على الـ
+
+798
+01:20:31,660 --> 01:20:35,700
+Level of the gene expression، أو البروتين اللي
+
+799
+01:20:35,700 --> 01:20:45,520
+موجود. هاي أمثلة عشان الـ Multiple للـ Beta-
+
+800
+01:20:45,520 --> 01:20:51,770
+-Thalassaemia. بالنسبة للـ Gene shift، Nonsense codon،
+
+801
+01:20:51,770 --> 01:20:56,990
+Unstable Globulin، Small Deletion، RNA، كذا يعني
+
+802
+01:20:56,990 --> 01:21:02,350
+تأثيرات الـ Mutations اللي بتسوي Beta-thalassemia،
+
+803
+01:21:02,350 --> 01:21:05,690
+الآن
+
+804
+01:21:05,690 --> 01:21:14,170
+تفاصيلها بدنا نأجلها، ماشي؟ بالنسبة للـ Alpha
+
+805
+01:21:14,170 --> 01:21:14,970
+-thalassemia،
+
+806
+01:21:17,530 --> 01:21:24,310
+اللي طبعًا حكينا هاي آسف، هاي كمان للـ Beta، هاي للـ
+
+807
+01:21:24,310 --> 01:21:31,550
+Beta، هاي أنواع الـ Eta والـ G Gamma والـ A Gamma،
+
+808
+01:21:31,550 --> 01:21:38,010
+وكده، وبيحطوا كيف في كل population من الـ Humans في
+
+809
+01:21:38,010 --> 01:21:42,270
+إشي مختلف، ليش؟
+
+810
+01:21:50,200 --> 01:22:03,800
+طيب، هاي بقول، بالنسبة لو افترضنا أنه
+
+811
+01:22:03,800 --> 01:22:14,060
+بقول بالنسبة لقضية المرتفعات، لا، هاي الـ «سلايدات»
+
+812
+01:22:14,060 --> 01:22:15,600
+مش كاملة، آسف.
+
+813
+01:22:18,100 --> 01:22:24,000
+بالنسبة لقضية المرتفعات، آخر slide أنا حاطه، بس فيه
+
+814
+01:22:24,000 --> 01:22:29,480
+أشياء بعدين ممكن نحكيها، و للمرة الجاية برجع بعيد
+
+815
+01:22:29,480 --> 01:22:39,740
+عليها من الأول. بالنسبة لقضية أن، يعني يعني
+
+816
+01:22:39,740 --> 01:22:46,500
+محاولة تفسير ليش بعض الأمراض أكثر في بعض الـ
+
+817
+01:22:46,500 --> 01:22:54,990
+populations، في بعض المجموعات البشرية، ليش؟ شو اسمه؟
+
+818
+01:22:54,990 --> 01:22:59,890
+وقد يكون جزء من الموضوع اللي هي قضية أن إذا
+
+819
+01:22:59,890 --> 01:23:08,930
+البيئة فيها، يعني إذا فيها ميزة معينة، فيها ميزة معينة،
+
+820
+01:23:08,930 --> 01:23:18,110
+بتفضل أو بتنفر مجموعة معينة. فاللي عنده S-Hemoglobin،
+
+821
+01:23:18,110 --> 01:23:26,110
+بيحب، أو بيقدر، أو بيحمل يروح يعيش في المرتفعات، راح
+
+822
+01:23:26,110 --> 01:23:32,950
+يقول لا، لأن المرتفعات الأكسجين فيها أقل، الـ21%
+
+823
+01:23:32,950 --> 01:23:36,530
+اللي بتعرفوها هذه لنسبة الأكسجين في الهواء على سطح
+
+824
+01:23:36,530 --> 01:23:42,130
+البحر. كل ما تطلع فوق، ماشي، راح تلاقي نسبة
+
+825
+01:23:42,130 --> 01:23:46,980
+الأكسجين أقل. فاحتمالية أن واحد عنده SS hemoglobin،
+
+826
+01:23:46,980 --> 01:23:52,960
+يصير عنده attack، ويصير عنده crisis أكبر لما يرتفع
+
+827
+01:23:52,960 --> 01:23:58,340
+الواحد على سطح البحر. فهي زي ما حكينا، كجانب منفر،
+
+828
+01:23:58,340 --> 01:24:02,780
+لهذا الميزة، يعني على عكس بتعطيه disadvantage،
+
+829
+01:24:02,780 --> 01:24:10,380
+بتعطيه ضغط، يعني بـ بـ بـ، يعني ما بتعطيهوش أفضلية،
+
+830
+01:24:10,380 --> 01:24:17,040
+بتعطيه بارد، يعني بيحب ينزل على الـ الـ الـ، على الـ
+
+831
+01:24:17,040 --> 01:24:20,300
+sea level، عشان نسبة الأكسجين أكثر، وإذا نسبة الـ
+
+832
+01:24:20,300 --> 01:24:25,980
+Oxygen أكثر في الأغوار وفي مكان بـ low sea level
+
+833
+01:24:25,980 --> 01:24:31,700
+أكثر، ممكن أنه يكون يحب يروح هناك، لأنه بيشوف حاله
+
+834
+01:24:31,700 --> 01:24:37,340
+أحسن، ما بيصيبوش نفس المرض، في أي ناحية بالنسبة للـ
+
+835
+01:24:37,340 --> 01:24:43,990
+Alpha Thalassemia. الـ Thalassemia طبعًا يعني إلها
+
+836
+01:24:43,990 --> 01:24:50,150
+برضه أعراض كثيرة، بالذات، يعني فيه slide، بما أنه أنا
+
+837
+01:24:50,150 --> 01:24:56,250
+عندي أربعة copies من الـ، أربعة copies من الـ Alpha
+
+838
+01:24:56,250 --> 01:25:04,930
+genes، ماشي، اللي هي Alpha 1 و Alpha 
+
+889
+01:29:56,150 --> 01:30:03,690
+عيلة وعيلة الأمهات والآباء اتفقوا لو فحصوا لقوا
+
+890
+01:30:03,690 --> 01:30:10,030
+أنه في عدم تطابق في الغالب، لأ، ما يعني بيفرقش
+
+891
+01:30:10,030 --> 01:30:14,950
+الجيزة هذه لسبب طبي، وبلاش من هالجيزة هذه بالذات
+
+892
+01:30:14,950 --> 01:30:21,200
+يعني ممكن اختار فرض آخر، ولا كده. أحياناً المشاكل إذا
+
+893
+01:30:21,200 --> 01:30:26,380
+والله اثنين حبوا بعض وبيلا بدهم يتجوزوا، وشو ما يكون
+
+894
+01:30:26,380 --> 01:30:31,180
+يكون، وشو ما كذا، بتلاقي هنا بتلاقي فيه صعوبة أخرى
+
+895
+01:30:31,180 --> 01:30:35,080
+يعني اللي هي قضية إن في بعض المجتمعات وبعض الدول
+
+896
+01:30:35,080 --> 01:30:43,060
+بيصيروا يعملوا فحص للـThalassemia عند الحمل، في
+
+897
+01:30:43,060 --> 01:30:49,690
+أول الحمل، عشان لو كان الجنين مصاب، ماشي؟ وهذه
+
+898
+01:30:49,690 --> 01:30:55,010
+احتمالية إذا اثنين Carriers، ربع، وإذا الإنسان يطلع
+
+899
+01:30:55,010 --> 01:30:58,970
+منهم Carrier كمان، احتماليته نصف، واحتمالية تطلع
+
+900
+01:30:58,970 --> 01:31:03,810
+Completely Normal، إذا اتوا Carriers، ربع، فنتيجة
+
+901
+01:31:03,810 --> 01:31:09,710
+الاحتماليات هذه، احتمالية أنه اللي هي الربع، أنه
+
+902
+01:31:09,710 --> 01:31:17,570
+يكون الجنين مصاب. ففي ناس بعرضوا قضية اللي هي الـ
+
+903
+01:31:17,570 --> 01:31:21,610
+Termination أو الـAbortion، اللي هو الإجهاض، إذا
+
+904
+01:31:21,610 --> 01:31:27,370
+كان. وفيه الآن يعني بالذات للثلاسيميا، لأنه بيعتمد
+
+905
+01:31:27,370 --> 01:31:32,930
+على الـhematopoietic stem cells، والـcells تبعات
+
+906
+01:31:32,930 --> 01:31:37,390
+الـhematopoiesis، بيصيروا يعملوا، شو بيقولوله يعني؟
+
+907
+01:31:37,390 --> 01:31:41,510
+stem cell transplantation، بيحاولوا يغيروا من الـ
+
+908
+01:31:41,510 --> 01:31:47,750
+hemoglobin. وفيه يعني إذا بتسمعوا تقنية جديدة في
+
+909
+01:31:47,750 --> 01:31:52,890
+العالم ليه؟ CRISPR-Cas9، اللي هو عبارة عن بروتين بيقدر
+
+910
+01:31:52,890 --> 01:31:57,930
+الواحد إذا بيقدر يحدد وين الجين المصاب، يدخل ويعدله
+
+911
+01:31:57,930 --> 01:32:02,090
+فهي يعني الفكرة إن هاي الـHemoglobin Obesity
+
+912
+01:32:02,090 --> 01:32:12,380
+بتعطي challenges للإنسانية والبشرية، بحيث إنه يعني
+
+913
+01:32:12,380 --> 01:32:18,880
+في أمور كثيرة، تباينات بين الدول، في كيف يتعاملوا مع
+
+914
+01:32:18,880 --> 01:32:23,920
+الموضوع هذا. في أسئلة؟
+
+915
+01:32:23,920 --> 01:32:27,500
+أتأخرنا
+
+916
+01:32:27,500 --> 01:32:33,580
+في البداية، أتأخرنا شوية. بالنهاية، وإذا في أسئلة،
+
+917
+01:32:33,580 --> 01:32:40,040
+أيوة، سعادة، إسألي
+
+918
+01:32:41,680 --> 01:32:46,820
+كان عندي ميوت يا دكتور، بدي أرجع للـ… للـsickle
+
+919
+01:32:46,820 --> 01:32:50,580
+-cell anemia، إن الـmutation بتحول لـGlutamine
+
+920
+01:32:50,580 --> 01:32:56,360
+لـValine، تمام؟ - أجل - والـGlutamine charged
+
+921
+01:32:56,360 --> 01:33:00,180
+وValine uncharged. لما يصير عندي uncharged، إيش
+
+922
+01:33:00,180 --> 01:33:03,380
+الفكرة اللي بدها تصير؟ اللي تخلّي الديوكسي والأخطبوط
+
+923
+01:33:03,380 --> 01:33:08,680
+هي؟ يعني من الأساس، أساس الفكرة - حكيتلك إياها -
+
+924
+01:33:08,680 --> 01:33:13,630
+إنت قطع شوية الفترة - أتناولك، أتناولك - الـGlutamine
+
+925
+01:33:13,630 --> 01:33:20,470
+hydrophilic، يعني بيحب الميه - أه، لأنه charged -
+
+926
+01:33:20,470 --> 01:33:25,230
+أه، والثاني hydrophobic، يعني ما بيحبش الميه، بيتخبأ من
+
+927
+01:33:25,230 --> 01:33:30,550
+الميه. فهذا المكان اللي.. اللي محل ستة هذا سطحي
+
+928
+01:33:30,550 --> 01:33:34,990
+يعني على السطح. لما نكون يعني هيك الـtheory أو هيك
+
+929
+01:33:34,990 --> 01:33:39,710
+التواضع، لما نكون الـValine هو اللي موجود على
+
+930
+01:33:39,710 --> 01:33:45,130
+السطح، وبالذات الـdeoxy، ما بيحبش هاي الـstatus، ما بيحبش
+
+931
+01:33:45,130 --> 01:33:51,190
+هذا الوضع، فبيحاول كل ثنتين ذرات يلسقن بعض عشان
+
+932
+01:33:51,190 --> 01:33:55,690
+يكبو بعض، ما يكونوش الثنتين على السطح، يعني بيصير يـ
+
+933
+01:33:55,690 --> 01:34:01,270
+clumping، بيصير هيك يتجمع مع بعض. أقراها
+
+934
+01:34:01,270 --> 01:34:07,010
+وحاولوا تفهموها يعني، لأنه يعني زي ما أقول كرة
+
+935
+01:34:07,010 --> 01:34:13,150
+الأصل سطحها ملصق مثلاً، في جزء منها بيلزق، خيتي اللي
+
+936
+01:34:13,150 --> 01:34:18,090
+راح يصير إنه إذا الجزء اللي ملزق على السطح، والكورة
+
+937
+01:34:18,090 --> 01:34:22,910
+اللي جنبها عليها برضه إيش؟ بيلزق على السطح، الاثنتين
+
+938
+01:34:22,910 --> 01:34:32,610
+بيلزقوا بعض عشان يخبوا بعض، هيك بدأت كونها، أوي
+
+939
+01:34:32,610 --> 01:34:36,190
+حتى الآن، تمام. خلاص، بحاول أرجعلها من الكتاب كمان
+
+940
+01:34:36,190 --> 01:34:38,990
+يعني ولو، وإندي أسئلة، أكيد هبعتلك اليوم يا دكتور
+
+941
+01:34:39,700 --> 01:34:45,240
+أهلاً وسهلاً، طيب، الله يعطيكم العافية، ونشوفكم إن
+
+942
+01:34:45,240 --> 01:34:48,980
+شاء الله يومنا نرجع، في أسئلة ثانية؟ بضالي؟ آه،
+
+943
+01:34:48,980 --> 01:34:53,420
+آه، بضالي، سمحت يعني بقصة إنه اللي هو الـcarrier
+
+944
+01:34:53,420 --> 01:34:57,440
+للـthalassemia، بأخر إشي لما حكينا microcyte، لما
+
+945
+01:34:57,440 --> 01:35:00,200
+يكون عنده microcytosis بالخلايا، حتى لو كان
+
+946
+01:35:00,200 --> 01:35:04,420
+الهيموغلوبين كويس، ممكن الـcarriers للـthalassemia
+
+947
+01:35:04,420 --> 01:35:07,540
+أو alpha-thalassemia يكون عنده microcytosis، هاي
+
+948
+01:35:08,050 --> 01:35:10,930
+ولا؟ لازم يكون عندهم الـmicropolychromasia، يعني ممكن
+
+949
+01:35:10,930 --> 01:35:16,810
+تكون عندهم الميزة، الـcarrier ولا المصاب؟ لأ،
+
+950
+01:35:16,810 --> 01:35:19,550
+الـcarrier بحكي عنه، بحكي عن الـcarrier
+
+951
+01:35:19,550 --> 01:35:26,290
+الـcarrier؟ آه، آه، يعني يتزق من الـ… إذا أنتم
+
+952
+01:35:26,290 --> 01:35:30,930
+سريرياً ما أخذتو شي كثير، الـCBC، الـComplete
+
+953
+01:35:30,930 --> 01:35:38,760
+Blood Count، ماشي؟ لما واحد يصير عنده أنيميا، أو فيه
+
+954
+01:35:38,760 --> 01:35:43,020
+مشكلة بالنسبة للدم، أكثر شيء السبب اللي هو الـIron
+
+955
+01:35:43,020 --> 01:35:47,280
+Deficiency Anemia، الـIron Deficiency Anemia، بيكون
+
+956
+01:35:47,280 --> 01:35:52,280
+عنده Microcytosis، وAnisocytosis
+
+957
+01:35:52,280 --> 01:35:58,960
+وطبعاً Low Hemoglobin، وشو اسمه؟ يعني Microcytic
+
+958
+01:35:58,960 --> 01:36:05,980
+Hypochromic Anemia، اللي هو يعني الـMCHC. إذا أنت
+
+959
+01:36:05,980 --> 01:36:10,300
+بتشوفي الـCBC، إذا شفتي نتيجة الـCBC اللي بتطلع
+
+960
+01:36:10,300 --> 01:36:17,800
+من الجهاز، فيها معلومات كثيرة، الـHemoglobin، و
+
+961
+01:36:17,800 --> 01:36:24,700
+بعدين الـMCH اللي هو الـMean Corpuscular Volume
+
+962
+01:36:24,700 --> 01:36:33,810
+MCV، وMCH، وMCHC، فهي فيه مؤشرات. إذا الـ… الـIron
+
+963
+01:36:33,810 --> 01:36:39,510
+Deficiency Anemia، الفكرة تبعها الخلايا بتكون
+
+964
+01:36:39,510 --> 01:36:44,670
+بتصغر. بيكون الإنسان بالأول طبيعي، وفيه حجم الخلايا
+
+965
+01:36:44,670 --> 01:36:50,290
+قريب من الطبيعي، وطبيعي. ففيه تفاوت في حجم الخلايا
+
+966
+01:36:50,290 --> 01:36:54,950
+أما إذا كل الخلايا صغيرة، بنفس الشكل، بنفس الحجم،
+
+967
+01:36:54,950 --> 01:37:01,340
+مافيش تفاوت بينهم، الـRDW رح يكون Normal، بس الـMCV
+
+968
+01:37:01,340 --> 01:37:08,400
+Low. عشان الـCarrier، حتى إنه إذا حجم الخلية صغير،
+
+969
+01:37:08,400 --> 01:37:13,420
+ويكون عنده Hemoglobin كويس، بيكون عنده Increased
+
+970
+01:37:13,420 --> 01:37:20,500
+number of red blood cells، ماشي؟ فهذا بيتعود، فيه
+
+971
+01:37:20,500 --> 01:37:27,000
+تغيرات معينة، إذا إنسان بلاقي مثلاً كرات الدم الحمراء
+
+972
+01:37:27,730 --> 01:37:32,490
+اللي عادةً مثلاً من 3.5 إلى 5 مليون per cubic
+
+973
+01:37:32,490 --> 01:37:39,890
+millimeter، فلما تصير حوالي 6، 6.5، والـMCV Low،
+
+974
+01:37:39,890 --> 01:37:47,130
+والهيموغلوبين 12، 13، 11،  الجهات الواطية يعني، أوطى
+
+975
+01:37:47,130 --> 01:37:52,350
+من الطبيعي، بقول شبه متأكد إن هذا ثلاسيميا ألفا
+
+976
+01:37:52,350 --> 01:37:57,940
+ثلاسيميا Carrier، مش مصاب. المصاب الـHemoglobin
+
+977
+01:37:57,940 --> 01:38:05,700
+بيكون 8، 5، 6، 7، Very Low. Low، أه، بيكون Low. فمن
+
+978
+01:38:05,700 --> 01:38:10,060
+الـCBC العادي، فبقول
+
+979
+01:38:10,060 --> 01:38:14,640
+بالنسبة لفحص الـCBC العادي، ممكن الإشتباه للـAlpha
+
+980
+01:38:14,640 --> 01:38:19,820
+Thalassemia Carrier State، يكون الواحد شبه متأكد إذا
+
+981
+01:38:19,820 --> 01:38:25,690
+الـMCV Normal، لأ، مافيش Alpha Thalassemia. طبعاً، دا
+
+982
+01:38:25,690 --> 01:38:29,130
+أكد آخر معلومة يا دكتور، معلش طولت. عالـBeta
+
+983
+01:38:29,130 --> 01:38:33,790
+-thalassemia، مافيهاش deletion بشكل عام، بس في عندي،
+
+984
+01:38:33,790 --> 01:38:39,150
+بس يعني عندي quantity abnormal، بطرق
+
+985
+01:38:39,150 --> 01:38:43,590
+أخرى، بغير الـ… بطرق أخرى، بس بيبقى عندي الـAlpha
+
+986
+01:38:43,590 --> 01:38:48,840
+-thalassemia، فيها deletion، ما اللي حكيت أنا فيه
+
+987
+01:38:48,840 --> 01:38:54,120
+أشياء مش موجودة، راح نعرضهم الأسبوع الجاي، اللي هو
+
+988
+01:38:54,120 --> 01:38:59,920
+أنه ممكن يلاقي هم أصلاً بيكونوا أربع جينات من Alpha،
+
+989
+01:38:59,920 --> 01:39:04,840
+ممكن يلاقي واحدة، رايحين تلاتة، أو اثنين، أو واحد، أو
+
+990
+01:39:04,840 --> 01:39:10,420
+صفر. كل الاحتمالات واردة، كل الاحتمالات
+
+991
+01:39:10,420 --> 01:39:13,780
+واردة. الـSevere اللي هم لما يكون عندي تلاتة يعني
+
+992
+01:39:13,780 --> 01:39:15,980
+ممكن يكون راح عندي تلاتة من Alpha، أو أربعة من
+
+993
+01:39:15,980 --> 01:39:21,890
+Alpha، وما يكونش عندي Alpha خالص. حتى أربعة يمكن أن
+
+994
+01:39:21,890 --> 01:39:26,730
+يكون عندي موت للجنين في مرحلة جنينية، والسبب أنه
+
+995
+01:39:26,730 --> 01:39:31,430
+ما عندي Alpha genes. Alpha genes، نعم، صحيح،
+
+996
+01:39:31,430 --> 01:39:34,690
+جزاك الله خيراً. استمعت، هيك المعلومات صارت واضحة. يعطيك
+
+997
+01:39:34,690 --> 01:39:40,270
+العافية يا دكتور، يعطيك
+
+998
+01:39:40,270 --> 01:39:45,530
+العافية يا دكتور، الله يسهل عليك. يلا، السلام
+
+999
+01:39:45,530 --> 01:39:45,830
+عليك
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/A4ftaxBd5gA_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/A4ftaxBd5gA_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..92d7e2db6b7bf0f8558d9adf0509e0c5bdadc2f4
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/A4ftaxBd5gA_raw.json
@@ -0,0 +1 @@
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نفكر بالنسبة للـGenetic Diseases into three types، main types", "tokens": [2304, 25720, 6055, 7649, 10632, 11331, 995, 12610, 14739, 11622, 1211, 6055, 33753, 23032, 1829, 3555, 5296, 15042, 8717, 30544, 12399, 1975, 5016, 8315, 37495, 22653, 5296, 31377, 2304, 8717, 5172, 37983, 20666, 1863, 35457, 3660, 24976, 39184, 26647, 3532, 30161, 1957, 666, 1045, 3467, 12399, 2135, 3467], "avg_logprob": -0.30022322401708484, "compression_ratio": 1.2214285714285715, "no_speech_prob": 2.4080276489257812e-05, "words": [{"start": 733.39, "end": 733.97, "word": "مرة", "probability": 0.623291015625}, {"start": 733.97, "end": 734.57, "word": " تانية", "probability": 0.8743489583333334}, {"start": 734.57, "end": 741.21, "word": " حاول", "probability": 0.7017415364583334}, {"start": 741.21, "end": 741.65, "word": " أنزل", "probability": 0.9729817708333334}, {"start": 741.65, "end": 742.13, "word": " تحت", "probability": 0.854248046875}, {"start": 742.13, "end": 744.77, "word": " طيب", "probability": 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بيبقى Problem فده الـ George's Syndrome الصحيح فالـ 31 What's the main driving force for normal for female sex", "tokens": [6027, 3224, 32640, 38688, 26895, 25528, 316, 4032, 33, 6225, 3555, 9640, 3660, 18871, 31248, 18083, 16070, 39184, 2033, 335, 39592, 37893, 9122, 2288, 20498, 11622, 20498, 12399, 8608, 1829, 7435, 27842, 3215, 12399, 9122, 2288, 20498, 11622, 20498, 9122, 10943, 1211, 12399, 4724, 1829, 3555, 4587, 7578, 11676, 6156, 3215, 3224, 2423, 39184, 7136, 311, 44545, 31767, 5016, 1829, 5016, 6156, 6027, 39184, 10353, 708, 311, 264, 2135, 4840, 3464, 337, 2710, 337, 6556, 3260], "avg_logprob": -0.46306818027000923, "compression_ratio": 1.2890995260663507, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 4037.27, "end": 4038.45, "word": "الهيموفيليا", "probability": 0.6940104166666666}, {"start": 4038.45, "end": 4038.73, "word": " A", "probability": 0.55810546875}, {"start": 4038.73, "end": 4039.23, "word": " وB", "probability": 0.879638671875}, {"start": 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mutation", "probability": 0.9140625}], "temperature": 1.0}, {"id": 163, "seek": 459206, "start": 4565.28, "end": 4592.06, "text": "يعني نفس الجين موجود بالثنتين بس الأصل يكون البروتين عبارة عن Trans-Membrane Domain وIntra-Cytoplasmic Membrane والـ Extra-Cytoplasmic يعني Extra-Cytoplasmic والـ Trans-Membrane والـ Intra-Cytoplasmic تاني هيك الأصل فالـ DNA متشابه فالـ explanation", "tokens": [40228, 22653, 8717, 36178, 25724, 9957, 3714, 29245, 23328, 20666, 12984, 29399, 9957, 4724, 3794, 16247, 36520, 7251, 30544, 2423, 26890, 35473, 9957, 6225, 3555, 9640, 3660, 18871, 6531, 12, 44, 443, 1443, 1929, 16674, 491, 4032, 25597, 424, 12, 34, 4328, 404, 7743, 13195, 8731, 1443, 1929, 16070, 39184, 29429, 12, 34, 4328, 404, 7743, 13195, 37495, 22653, 29429, 12, 34, 4328, 404, 7743, 13195, 16070, 39184, 6531, 12, 44, 443, 1443, 1929, 16070, 39184, 5681, 424, 12, 34, 4328, 404, 7743, 13195, 6055, 7649, 1829, 39896, 4117, 16247, 36520, 6156, 6027, 39184, 8272, 44650, 8592, 16758, 3224, 6156, 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فيها أسئلة ماقدتش أبدأ فيها من ناحية إنه خلّينا ناخد شوية يعني خميرة من المعلومات العلمية وأخيرًا يعني تفاصيل الأمراض، هاي إن شاء الله", "tokens": [6027, 10721, 3794, 19986, 37977, 13672, 1829, 10874, 14407, 3555, 2655, 11296, 20328, 5016, 8978, 9673, 14407, 3215, 4724, 3794, 13672, 1829, 6225, 9640, 4587, 8978, 3714, 9778, 1829, 5551, 4117, 2655, 2288, 9154, 45595, 20498, 3714, 25720, 16247, 8592, 1829, 16606, 13672, 1829, 10874, 14407, 3555, 2655, 11296, 32771, 1211, 9566, 4032, 3615, 9640, 5172, 2655, 32239, 8592, 10874, 14407, 3555, 2655, 11296, 32771, 1211, 9566, 16490, 1211, 14407, 5551, 24401, 10874, 11622, 38207, 9154, 32748, 23557, 3794, 3660, 8717, 8592, 38688, 9673, 2288, 26108, 3615, 41850, 9673, 2288, 26108, 3615, 13672, 1829, 8978, 11296, 5551, 3794, 19986, 37977, 19446, 28543, 2655, 8592, 5551, 44510, 10721, 8978, 11296, 9154, 8717, 39319, 10632, 36145, 3224, 16490, 1211, 11703, 1829, 8315, 8717, 47283, 3215, 13412, 2407, 10632, 37495, 22653, 16490, 2304, 48923, 9154, 9673, 30241, 20498, 9307, 18863, 19528, 10632, 36725, 9778, 13546, 14111, 995, 37495, 22653, 6055, 5172, 33546, 26895, 16247, 29973, 46958, 12399, 8032, 47302, 36145, 13412, 16606, 21984], "avg_logprob": -0.12111801538408173, "compression_ratio": 2.1132075471698113, "no_speech_prob": 0.00286865234375, "words": [{"start": 5438.63, "end": 5439.23, "word": "الأسئلة", "probability": 0.97890625}, {"start": 5439.23, "end": 5439.41, "word": " اللي", "probability": 0.947265625}, {"start": 5439.41, "end": 5439.91, "word": " جوابتها", "probability": 0.882958984375}, {"start": 5439.91, "end": 5440.13, "word": " صح", "probability": 0.991455078125}, {"start": 5440.13, "end": 5440.29, "word": " في", "probability": 0.9130859375}, {"start": 5440.29, "end": 5441.07, "word": " المواد", "probability": 0.9392903645833334}, {"start": 5441.07, "end": 5441.47, "word": " بس", "probability": 0.890380859375}, {"start": 5441.47, "end": 5441.87, "word": " اللي", "probability": 0.843017578125}, {"start": 5441.87, "end": 5442.23, "word": " عارق", "probability": 0.9676106770833334}, {"start": 5442.23, "end": 5442.37, "word": " في", "probability": 0.90625}, {"start": 5442.37, "end": 5442.67, "word": " مخي", "probability": 0.9637044270833334}, {"start": 5442.67, "end": 5443.03, "word": " أكتر", "probability": 0.98876953125}, {"start": 5443.03, "end": 5443.21, "word": " من", "probability": 0.98486328125}, {"start": 5443.21, "end": 5443.61, "word": " اليوم", "probability": 0.9609375}, {"start": 5443.61, "end": 5443.95, "word": " مرة", "probability": 0.992431640625}, {"start": 5443.95, "end": 5445.17, "word": " الأشياء", "probability": 0.988037109375}, {"start": 5445.17, "end": 5445.53, "word": " اللي", "probability": 0.9931640625}, {"start": 5445.53, "end": 5446.23, "word": " جوابتها", "probability": 0.93203125}, {"start": 5446.23, "end": 5446.65, "word": " غلط", "probability": 0.9578450520833334}, {"start": 5446.65, "end": 5447.55, "word": " وعارفت", "probability": 0.85546875}, {"start": 5447.55, "end": 5447.79, "word": " ليش", "probability": 0.951171875}, {"start": 5447.79, "end": 5448.27, "word": " جوابتها", "probability": 0.963671875}, {"start": 5448.27, "end": 5448.61, "word": " غلط", "probability": 0.9962565104166666}, {"start": 5448.61, "end": 5449.31, "word": " خلوا", "probability": 0.6290283203125}, {"start": 5449.31, "end": 5449.67, "word": " أحد", "probability": 0.6181640625}, {"start": 5449.67, "end": 5449.91, "word": " جزء", "probability": 0.9070638020833334}, {"start": 5449.91, "end": 5450.11, "word": " من", "probability": 0.99267578125}, {"start": 5450.11, "end": 5451.09, "word": " الدراسة", "probability": 0.9949951171875}, {"start": 5451.09, "end": 5451.89, "word": " نشوف", "probability": 0.819580078125}, {"start": 5451.89, "end": 5452.53, "word": " المراجع", "probability": 0.9490966796875}, {"start": 5452.53, "end": 5452.85, "word": " أنا", "probability": 0.857421875}, {"start": 5452.85, "end": 5453.51, "word": " المراجع", "probability": 0.9605712890625}, {"start": 5453.51, "end": 5453.71, "word": " اللي", "probability": 0.9921875}, {"start": 5453.71, "end": 5454.01, "word": " فيها", "probability": 0.9912109375}, {"start": 5454.01, "end": 5454.57, "word": " أسئلة", "probability": 0.99365234375}, {"start": 5454.57, "end": 5455.85, "word": " ماقدتش", "probability": 0.6033935546875}, {"start": 5455.85, "end": 5456.17, "word": " أبدأ", "probability": 0.9716796875}, {"start": 5456.17, "end": 5456.49, "word": " فيها", "probability": 0.981689453125}, {"start": 5456.49, "end": 5456.69, "word": " من", "probability": 0.9736328125}, {"start": 5456.69, "end": 5457.17, "word": " ناحية", "probability": 0.9923502604166666}, {"start": 5457.17, "end": 5457.63, "word": " إنه", "probability": 0.834716796875}, {"start": 5457.63, "end": 5458.33, "word": " خلّينا", "probability": 0.683984375}, {"start": 5458.33, "end": 5458.73, "word": " ناخد", "probability": 0.8426106770833334}, {"start": 5458.73, "end": 5459.23, "word": " شوية", "probability": 0.8893229166666666}, {"start": 5459.23, "end": 5459.99, "word": " يعني", "probability": 0.807373046875}, {"start": 5459.99, "end": 5460.49, "word": " خميرة", "probability": 0.9567057291666666}, {"start": 5460.49, "end": 5460.73, "word": " من", "probability": 0.98291015625}, {"start": 5460.73, "end": 5461.71, "word": " المعلومات", "probability": 0.9935302734375}, {"start": 5461.71, "end": 5462.77, "word": " العلمية", "probability": 0.99267578125}, {"start": 5462.77, "end": 5464.43, "word": " وأخيرًا", "probability": 0.86142578125}, {"start": 5464.43, "end": 5464.85, "word": " يعني", "probability": 0.9130859375}, {"start": 5464.85, "end": 5465.57, "word": " تفاصيل", "probability": 0.9918212890625}, {"start": 5465.57, "end": 5467.21, "word": " الأمراض،", "probability": 0.83990478515625}, {"start": 5467.21, "end": 5467.49, "word": " هاي", "probability": 0.5191650390625}, {"start": 5467.49, "end": 5467.69, "word": " إن", "probability": 0.80712890625}, {"start": 5467.69, "end": 5467.87, "word": " شاء", "probability": 0.9697265625}, {"start": 5467.87, "end": 5468.01, "word": " الله", "probability": 0.9677734375}], "temperature": 1.0}, {"id": 197, "seek": 548360, "start": 5468.44, "end": 5483.6, "text": "عندكم طريق طويل تاخدوها بعدين يالله يعطيكم العافية يعطيك ألف عافية دكتور الله يحييكم نشوفكم يوم الأربعة ان شاء الله رب العالمين يعطيكم العافية دكاترة نشوفكم ان شاء الله يوم الأولى", "tokens": [3615, 41260, 24793, 23032, 16572, 4587, 23032, 2407, 26895, 6055, 47283, 3215, 2407, 11296, 39182, 9957, 7251, 6027, 43761, 37495, 9566, 1829, 24793, 18863, 31845, 10632, 37495, 9566, 1829, 4117, 5551, 46538, 6225, 31845, 10632, 11778, 4117, 2655, 13063, 21984, 7251, 5016, 1829, 1829, 24793, 8717, 8592, 38688, 24793, 7251, 20498, 16247, 25513, 27884, 16472, 13412, 16606, 21984, 12602, 3555, 18863, 45340, 9957, 37495, 9566, 1829, 24793, 18863, 31845, 10632, 11778, 4117, 9307, 25720, 8717, 8592, 38688, 24793, 16472, 13412, 16606, 21984, 7251, 20498, 16247, 12610, 7578], "avg_logprob": -0.19335937652398238, "compression_ratio": 2.1298701298701297, "no_speech_prob": 6.079673767089844e-06, "words": [{"start": 5468.44, "end": 5468.88, "word": "عندكم", "probability": 0.4779866536458333}, {"start": 5468.88, "end": 5469.24, "word": " طريق", "probability": 0.7169596354166666}, {"start": 5469.24, "end": 5469.64, "word": " طويل", "probability": 0.9347330729166666}, {"start": 5469.64, "end": 5470.14, "word": " تاخدوها", "probability": 0.93134765625}, {"start": 5470.14, "end": 5471.02, "word": " بعدين", "probability": 0.81884765625}, {"start": 5471.02, "end": 5472.08, "word": " يالله", "probability": 0.73193359375}, {"start": 5472.08, "end": 5472.48, "word": " يعطيكم", "probability": 0.9052734375}, {"start": 5472.48, "end": 5473.18, "word": " العافية", "probability": 0.849609375}, {"start": 5473.18, "end": 5473.98, "word": " يعطيك", "probability": 0.8824462890625}, {"start": 5473.98, "end": 5474.16, "word": " ألف", "probability": 0.843505859375}, {"start": 5474.16, "end": 5474.4, "word": " عافية", "probability": 0.91064453125}, {"start": 5474.4, "end": 5474.9, "word": " دكتور", "probability": 0.8941650390625}, {"start": 5474.9, "end": 5475.3, "word": " الله", "probability": 0.60693359375}, {"start": 5475.3, "end": 5475.9, "word": " يحييكم", "probability": 0.85654296875}, {"start": 5475.9, "end": 5476.34, "word": " نشوفكم", "probability": 0.8681640625}, {"start": 5476.34, "end": 5476.56, "word": " يوم", "probability": 0.9921875}, {"start": 5476.56, "end": 5477.14, "word": " الأربعة", "probability": 0.8323567708333334}, {"start": 5477.14, "end": 5477.82, "word": " ان", "probability": 0.4677734375}, {"start": 5477.82, "end": 5478.08, "word": " شاء", "probability": 0.944580078125}, {"start": 5478.08, "end": 5478.2, "word": " الله", "probability": 0.94775390625}, {"start": 5478.2, "end": 5478.44, "word": " رب", "probability": 0.872314453125}, {"start": 5478.44, "end": 5479.82, "word": " العالمين", "probability": 0.9978841145833334}, {"start": 5479.82, "end": 5481.18, "word": " يعطيكم", "probability": 0.95068359375}, {"start": 5481.18, "end": 5481.46, "word": " العافية", "probability": 0.9794921875}, {"start": 5481.46, "end": 5481.96, "word": " دكاترة", "probability": 0.8043212890625}, {"start": 5481.96, "end": 5482.92, "word": " نشوفكم", "probability": 0.9124755859375}, {"start": 5482.92, "end": 5483.04, "word": " ان", "probability": 0.75927734375}, {"start": 5483.04, "end": 5483.16, "word": " شاء", "probability": 0.990234375}, {"start": 5483.16, "end": 5483.2, "word": " الله", "probability": 0.97607421875}, {"start": 5483.2, "end": 5483.36, "word": " يوم", "probability": 0.98779296875}, {"start": 5483.36, "end": 5483.6, "word": " الأولى", "probability": 0.633544921875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 5488.1291875, "duration_after_vad": 5313.650968750022}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/DpkVcBuiaNg_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/DpkVcBuiaNg_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..9f5be635a1d945170a2a7e937cf0ce56a2323b49
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/DpkVcBuiaNg_postprocess.srt
@@ -0,0 +1,3233 @@
+1
+00:00:00,000 --> 00:00:04,560
+في آخر المحاضرة الأخيرة احنا استعجلنا شويه هيك بس
+
+2
+00:00:04,560 --> 00:00:11,360
+أظن كانت المفاهيم واضحة ويعني الواحد يعني بالنسبة
+
+3
+00:00:11,360 --> 00:00:21,320
+للطب الحديث الآن بتلاقي الإنسان يعني إمكانية إذا
+
+4
+00:00:21,320 --> 00:00:27,380
+في إمكانيات طبية وصحية في البلاد المتقدمةيعني إنه
+
+5
+00:00:27,380 --> 00:00:31,820
+فعلاً النظام الصحي يعتنب كل إنسان حسب احتياجه وحسب
+
+6
+00:00:31,820 --> 00:00:36,960
+أمراضه وحسب تاريخه المرضى يعني حتى كـ Family
+
+7
+00:00:36,960 --> 00:00:40,960
+History و لا Genetic Testing و لا كذا والآن
+
+8
+00:00:40,960 --> 00:00:45,540
+الأدوات والآلات إذا موجودة وممكن يعني الإمكانات
+
+9
+00:00:45,540 --> 00:00:50,270
+موجودة هتلاقي أمور جميلة ممكن الواحدإذا بعرفها
+
+10
+00:00:50,270 --> 00:00:56,050
+يسويها والكلام بشكل أساسي للأخوة والأخوات الطالبات
+
+11
+00:00:56,050 --> 00:01:02,650
+والطلاب المحاضرة الأخيرة حسب الكتاب عشان إن شاء
+
+12
+00:01:02,650 --> 00:01:10,750
+الله المرات القادمة نسير يعني نراجع الأسئلة
+
+13
+00:01:10,750 --> 00:01:11,350
+التبعات
+
+14
+00:01:13,920 --> 00:01:20,620
+تبعات الـ USMLE أو غيرهم من المراجع التانية إن شاء
+
+15
+00:01:20,620 --> 00:01:24,480
+الله بيكون أحنا يعني عند كل واحد بيقرأ هذه الأسئلة
+
+16
+00:01:24,480 --> 00:01:32,640
+يعني نوع من الفهم وممكن أه يكون فعلاً تمتحن لقدرات
+
+17
+00:01:32,640 --> 00:01:38,060
+الطالب والدكتور بشكل جيد حول المناعة اليوم
+
+18
+00:01:38,060 --> 00:01:44,370
+المحاضرة حقيقة الفصل الأخيربصراحة من أهم الفصول
+
+19
+00:01:44,370 --> 00:01:51,430
+وأنا أعتبرها من أجملها ولكن بالنسبة لي أنا ال ..
+
+20
+00:01:51,430 --> 00:01:57,330
+ال .. بالذات اللي حاطينه هو هم يعني ما بعبر عن شو
+
+21
+00:01:57,330 --> 00:02:01,840
+هيك طموحي أنه نتناقش في هذه الجوانبالجوانب
+
+22
+00:02:01,840 --> 00:02:07,300
+الأخلاقية والجوانب الاجتماعية والجوانب الفكرية في
+
+23
+00:02:07,300 --> 00:02:13,800
+طب الوراشة فالاسم الفصل الأخير في الكتاب قبل ما
+
+24
+00:02:13,800 --> 00:02:17,580
+يدخل في الأمراض وتفاصيلها «ethical and social
+
+25
+00:02:17,580 --> 00:02:23,340
+issues in genetics and genomics» فحقيقة يعني هذا
+
+26
+00:02:23,340 --> 00:02:30,240
+جانب أنا راح أحط مقدمتين، تلاتة حتىعلى الأقل
+
+27
+00:02:30,240 --> 00:02:35,720
+لخلفية كل واحد مننا الإسلامية العربية منطقة الشرق
+
+28
+00:02:35,720 --> 00:02:42,040
+الأوسط في هذا المكان تكون الأمور واضحة ويكون
+
+29
+00:02:42,040 --> 00:02:50,920
+الواحد عنده مبادئ أو نقاط ثابتة أو أسس ثابتة
+
+30
+00:02:50,920 --> 00:02:56,080
+بينطلق منها في التعامل في هذه الجوانبفالجوانب
+
+31
+00:02:56,080 --> 00:03:02,380
+الأخلاقية صراحة من أهم الجوانب وحقيقة الطب يعني
+
+32
+00:03:02,380 --> 00:03:08,560
+وأنا دايما بقول لطلابي إحنا بقوسين وظيفتكم الآن
+
+33
+00:03:08,560 --> 00:03:14,400
+تتعلموا فاحنا مطلوب منها أن نعلمكم ما مطلوب بس أن
+
+34
+00:03:14,400 --> 00:03:18,160
+أعلمكم التشريح والعلوم الطبية وكيف تتعامل مع
+
+35
+00:03:18,160 --> 00:03:24,230
+المريض وكذا فيه جوانب أخلاقية لازم تتعلمهاولازم
+
+36
+00:03:24,230 --> 00:03:28,130
+تعرفها فحقيقة
+
+37
+00:03:28,130 --> 00:03:34,110
+أنا بظن أنه على الأقل الحمد لله بالنسبة أن كمسلمين
+
+38
+00:03:34,110 --> 00:03:41,330
+وعرب أن تاريخ والوضوح
+
+39
+00:03:41,330 --> 00:03:48,390
+كبير جدا وإن كان حتى قبل الإسلام وقبل العرب هناك
+
+40
+00:03:48,390 --> 00:03:53,580
+مبادئ عالميةبيشترك فيها الناس كلها فيه شويه جوانب
+
+41
+00:03:53,580 --> 00:03:59,400
+الأخلاقية في الطب ابتداءًا وبعد ذلك أكتر في الـ
+
+42
+00:03:59,400 --> 00:04:04,080
+الوراثة وعلوم الوراثة والإمكانات الحديثة وكيف
+
+43
+00:04:04,080 --> 00:04:09,420
+الواحد يتعامل مع هذه الجوانب المقدمتين اللي كنت
+
+44
+00:04:09,420 --> 00:04:16,260
+حابب أني أذكرهم أولًا يعني أنا أظن كل واحد منكم
+
+45
+00:04:16,260 --> 00:04:21,890
+بيعرف أنهمجرد ما اتقرر بتخلص من الجامعة وإن شاء
+
+46
+00:04:21,890 --> 00:04:27,290
+الله في حفلة التخرج بتقسم هذا القسم حقيقة قسم مهم
+
+47
+00:04:27,290 --> 00:04:34,970
+وأقرأه ويعني هذا قسم جزء كبير منه مأخوذ حتى من ما
+
+48
+00:04:34,970 --> 00:04:39,750
+يسمى قسم أبقراأبو قراط اللي هو يعتبر من الأسور
+
+49
+00:04:39,750 --> 00:04:46,710
+اليونانية يعني قبل ميلاد سيدنا المسيح بكذا 400
+
+50
+00:04:46,710 --> 00:04:52,570
+سنة، 500 سنة على الأقل لقى مشهور وبيتكلم عن نفس
+
+51
+00:04:52,570 --> 00:04:56,650
+المبادئ وإن كان يعني إذا حد قرأ نفس القسم القديم
+
+52
+00:04:57,020 --> 00:05:02,380
+علاقي إنه بيتكلم إنه بيحلف في أبولو ملك إله الطب
+
+53
+00:05:02,380 --> 00:05:08,360
+يعني بيخبص تخبصاتهم بس المبادئ الأساسية فإحنا لما
+
+54
+00:05:08,360 --> 00:05:12,820
+الواحد مننا يقسم أقسم بالله العظيم أن أراقب الله
+
+55
+00:05:12,820 --> 00:05:17,560
+في مهنتيه وأن أسونا حياة الإنسان في كافة أدواره في
+
+56
+00:05:17,560 --> 00:05:22,760
+كل الظروف والأحوال باذلا وسعي استنقاذها من الهلاك
+
+57
+00:05:22,760 --> 00:05:28,570
+والمرض والألم والقلقمطلوب منه أن أحافظ على الإنسان
+
+58
+00:05:28,570 --> 00:05:32,590
+اللي أمامنا من الهلاك والمرض والألم والقلق وأن
+
+59
+00:05:32,590 --> 00:05:38,310
+أحفظ للناس كرامتهم وأستر عورتهم وأكفتهم سرهم وأن
+
+60
+00:05:38,310 --> 00:05:42,470
+أكون على الدوام من وسائل رحمة الله بادلا رعاية
+
+61
+00:05:42,470 --> 00:05:47,810
+الطبية للقريب والبعيد للصالح والخاطر والصديق
+
+62
+00:05:47,810 --> 00:05:52,710
+والعدو وأن أثابر على طلب العلم وسأسخره لدفع
+
+63
+00:05:52,710 --> 00:05:57,570
+الإنسان لا لأذاهوأن أوقّر من علّمني وأعلم من
+
+64
+00:05:57,570 --> 00:06:01,590
+يصغرني وأكون أخل لكل زميل في المهنة الطبية
+
+65
+00:06:01,590 --> 00:06:07,030
+متعاونين على البر والتقوى وأن تكون حياتي مصداقة
+
+66
+00:06:07,030 --> 00:06:12,550
+إيماني في سرّي وعلى نيتي نقية مما يشينها تجاه الله
+
+67
+00:06:12,550 --> 00:06:17,270
+ورسوله والمؤمنين الله على ما أقول شهيد عقيقة يعني
+
+68
+00:06:17,270 --> 00:06:23,810
+مبادئ أنا بعتبر حفظ كرامة الإنسان حفظ سر الإنسان
+
+69
+00:06:24,280 --> 00:06:32,820
+حفظ الأحداث من الهلاك والمرض والألم والقلق وتعامل
+
+70
+00:06:32,820 --> 00:06:36,640
+مع الزملاء وغيرها هذه المبادئ الأخلاقية العامة
+
+71
+00:06:36,640 --> 00:06:44,960
+الطبية وهي مشمولة في القسم حقيقة لازم واحد يكون
+
+72
+00:06:44,960 --> 00:06:51,280
+متنبه لها ويكون مطبق لها يعني يتشربها ويعتبرها
+
+73
+00:06:51,280 --> 00:06:58,590
+مبادئتحكم تفكيره وتحكم يعني تصرفاته يعني ما بيصير
+
+74
+00:06:58,590 --> 00:07:02,630
+الواحد يكون مثلا فقط وظيفته أنا بدي أصبح دكتور
+
+75
+00:07:02,630 --> 00:07:09,930
+عشان ألم مصاري وأجرم الناس جرم بالمصاري وأكون احتم
+
+76
+00:07:09,930 --> 00:07:16,530
+مريض بدفع ودفيع وعنده مصاري أدور عليه واتقاتل أنا
+
+77
+00:07:16,530 --> 00:07:21,900
+والملاقمين راح يعمل العملية ومين راح يعالج هذا
+
+78
+00:07:21,900 --> 00:07:28,260
+المريض ولا كذا ولا كذا فحقيقة قسم
+
+79
+00:07:28,260 --> 00:07:33,960
+الطبيب من الأول وهذا ستاخدوه إن شاء الله في حفلة
+
+80
+00:07:33,960 --> 00:07:39,380
+التخرج أتوقع هيقعد في الدنيا كلها إنه كل واحد يجب
+
+81
+00:07:39,380 --> 00:07:44,120
+أن يقسم هذا ويجب الواحد مننا أن يعتبر هذا القسم
+
+82
+00:07:44,120 --> 00:07:49,480
+والميتاقبينه وبين الله الذي يراقبه بالسر والعلان
+
+83
+00:07:49,480 --> 00:07:56,720
+لوحدك ولا مع غيرك ولا كده لما
+
+84
+00:07:56,720 --> 00:08:01,660
+تكون طبيب تتعامل معاه إن شاء الله تكون المفاهيم
+
+85
+00:08:01,660 --> 00:08:05,620
+واضحة وإذا في حد عنده استفسار يا دكتور أحمد يكلمني
+
+86
+00:08:05,620 --> 00:08:13,740
+ماشي يعني الواحد بيكمل المحاضرة لما
+
+87
+00:08:13,740 --> 00:08:24,090
+تتعاملوترى بعد ذلك ما الذي يحكمك ما الذي يعني أنت
+
+88
+00:08:24,090 --> 00:08:32,350
+مطالب بتنفيذه وتنفيذه في حياتك
+
+89
+00:08:32,350 --> 00:08:41,810
+الطبية كطبيب في المجتمعهناك يعني من الـ يمكن في
+
+90
+00:08:41,810 --> 00:08:47,150
+فترة أن يكون الطالب يعني
+
+91
+00:08:47,150 --> 00:08:53,630
+في أعلى مقاعد الدراسة قد لا يكون عنده احتكاك وتفهم
+
+92
+00:08:53,630 --> 00:09:01,850
+ويعني وتطبيق لجوانب مفروض أساسية يكون الواحد فاهم
+
+93
+00:09:01,850 --> 00:09:12,130
+إحنا في أي بلدهناك قانون للصحة وهناك شيء اسمه
+
+94
+00:09:12,130 --> 00:09:18,470
+قانون الصحة زي قانون السير، زي قانون وزارة التعليم
+
+95
+00:09:18,470 --> 00:09:21,750
+وعنا يعني في القردن، لا أعرف إيش كانت النظام في
+
+96
+00:09:21,750 --> 00:09:27,590
+غزة بالنسبة كتطبيق يعني اللي هناك تلت أو أربع
+
+97
+00:09:27,590 --> 00:09:32,650
+درجات من الأنظمة والأشياء اللي احنا بنفتق عليها،
+
+98
+00:09:32,650 --> 00:09:38,080
+يعني بالأخيروالله أنا بسوق بالسيارة، دخلت عدوار،
+
+99
+00:09:38,080 --> 00:09:42,380
+دا عامة، بس يقول عليك أنت الحق، يقولك لأ أنت عليك
+
+100
+00:09:42,380 --> 00:09:46,780
+الحق، احنا بنحتكم لقانون، حتى لو ما انتبهناش، بس
+
+101
+00:09:46,780 --> 00:09:51,580
+احنا محكمين بالقانون، ولا بتصير حياة البشر غابة،
+
+102
+00:09:51,580 --> 00:09:58,300
+فالقانون طبعا أعلى قوانين أي مجتمع ما يسمى دستور
+
+103
+00:09:59,300 --> 00:10:02,440
+يمكن في غزة، ماعرفش كيف النظام يكون مائي بالمائي
+
+104
+00:10:02,440 --> 00:10:07,680
+بس بحكي عن الأردن الدستور الأردني الدستور هو يعني
+
+105
+00:10:07,680 --> 00:10:12,220
+شيء حتى في أمريكا الدستور الأمريكي وتعديلاته وكذا
+
+106
+00:10:12,220 --> 00:10:16,620
+وكذا كان المبادئ الحاكمة الأساسية للعقد الاجتماعي
+
+107
+00:10:16,620 --> 00:10:23,500
+للمجتمع بأكبر فالدستور يعني هو أساس القوانين
+
+108
+00:10:23,500 --> 00:10:30,890
+جميعًاوبالتالي هو الذي يعني يحكم كل شيء ويكون فيه
+
+109
+00:10:30,890 --> 00:10:37,270
+مبادئ عامة تمثل هوية المجتمع وهمية الدولة ومبادئها
+
+110
+00:10:37,270 --> 00:10:41,750
+وقيمها وجوانب تفصيلية أخرى للقضايا الكلية زي ما
+
+111
+00:10:41,750 --> 00:10:47,630
+بقول القانون يعني بيجي بعد الدستور هناك القوانين
+
+112
+00:10:48,200 --> 00:10:52,380
+القوانين زي قانون الصحة، قانون السير، قانون
+
+113
+00:10:52,380 --> 00:10:56,860
+العقوبات، قانون الجوانب
+
+114
+00:10:56,860 --> 00:11:01,240
+الكثيرة هنا، القانون الاقتصادية القانون إنها هو
+
+115
+00:11:01,240 --> 00:11:10,890
+الشيء الذيأو الأحكام أو المنظمة لنا اللي يعني في
+
+116
+00:11:10,890 --> 00:11:16,310
+الأردن تقترحها الحكومة لوافق عليها البرلمان
+
+117
+00:11:16,310 --> 00:11:21,470
+بالبرلمان اللي هو يعني المجلس النواب ومجلس العيال
+
+118
+00:11:21,470 --> 00:11:27,190
+أنها برلمانينوبعد ذلك بس يتم الموافق عليها والكل
+
+119
+00:11:27,190 --> 00:11:31,970
+يشترك في الموافق عليه توشح بإرادة ملكية ورئيس
+
+120
+00:11:31,970 --> 00:11:37,690
+الدولة أو الحكم بوافق عليها فهي يعني أعلى بعد
+
+121
+00:11:37,690 --> 00:11:42,490
+الدستور تيجي مرتبة ثانية بعدين هناك ما يسمى
+
+122
+00:11:42,490 --> 00:11:47,850
+الأنظمة الأنظمة ونظام زي مثلا نظام جامعة العلوم
+
+123
+00:11:47,850 --> 00:11:54,580
+والتكنولوجيا شايف عليك؟فالنظام هو يعني برضه
+
+124
+00:11:54,580 --> 00:12:01,320
+تعليمات نابعة من قانون بقوم الوزير، هو يعني صلاحية
+
+125
+00:12:01,320 --> 00:12:05,740
+الوزير لما أننا بدنا نغير في النظام إشي الوزير هو
+
+126
+00:12:05,740 --> 00:12:10,240
+اللي بيقدر يغير، مافيش داعي لمدّس نواب ومدّس عيال
+
+127
+00:12:10,240 --> 00:12:15,540
+وإرادة ملكية والمبادئ، هذا القانون، و بعدين في
+
+128
+00:12:15,540 --> 00:12:21,180
+داخل المؤسسةيعني هذه اللي مثلا عندنا وزير التعليم
+
+129
+00:12:21,180 --> 00:12:27,600
+العالي بيصدر بيسموه نظام الجامعات أو نظام كذا لإن
+
+130
+00:12:27,600 --> 00:12:30,780
+احنا اللي نحكم فيه وبعدين المستوى الأخير بيسموه
+
+131
+00:12:30,780 --> 00:12:35,020
+التعليمات التعليمات يعني أي مؤسسة زي جامعة العلوم
+
+132
+00:12:35,020 --> 00:12:39,740
+والتكنولوجيا الهندنية عندها تعليمات ترقية عضاء
+
+133
+00:12:39,740 --> 00:12:44,220
+الهيئة التدريس تعليمات نظام الإجازات أو تعليمات
+
+134
+00:12:44,220 --> 00:12:48,880
+الإجازات في هذه المؤسسةفالمهم، يعني الفكرة في هذا
+
+135
+00:12:48,880 --> 00:12:53,880
+الموضوع إنه الواحد مننا بده يكون متنبه لهذه
+
+136
+00:12:53,880 --> 00:12:58,700
+الأهمية هذه الجوال، بقول عشان هيك يعني البرلمانات،
+
+137
+00:12:58,700 --> 00:13:02,520
+إشي مهم، إحنا ما ناخدها إن والله هاي سياسي وشكلي
+
+138
+00:13:02,520 --> 00:13:07,480
+ومالهاش دخل، إحنا محكمين فيها، إحنا كشخاص قانون
+
+139
+00:13:07,480 --> 00:13:10,560
+السير بيمشي عليا، لو في إشي غلط بقانون السير،
+
+140
+00:13:10,560 --> 00:13:13,840
+المفروض يعدّل، يعني مش هالإشي الكبير، يعني
+
+141
+00:13:13,840 --> 00:13:19,410
+والسياسة 90% منهابتنظيم حياة الناس بتكون أشياء
+
+142
+00:13:19,410 --> 00:13:23,790
+يعني مش سهولة منك تتفق أجمع العقلة من الناس
+
+143
+00:13:23,790 --> 00:13:28,710
+الكبيرة فيها يعني فكل
+
+144
+00:13:28,710 --> 00:13:34,030
+بلد إلها قوانين وبدوا الواحد يكون فاهم شو قانون
+
+145
+00:13:34,030 --> 00:13:38,150
+البلد اللي أنا فيه قانون الصحة مثلا إنه أو راح
+
+146
+00:13:38,150 --> 00:13:42,250
+نيجي مثلا ندخل على مثلا سرية المعلومة وعدم سرية
+
+147
+00:13:42,250 --> 00:13:48,050
+المعلومة أنا بقولأحنا الأول أنا محكوم بقانون الصحة
+
+148
+00:13:48,050 --> 00:13:52,710
+ثم أمر المحكمة يعني مثلا عندنا في القانون في
+
+149
+00:13:52,710 --> 00:13:58,430
+الأردن بسبب يعني تأثيره على الصحة العامة إنسان
+
+150
+00:13:58,430 --> 00:14:07,050
+عنده ثلج إنسان عنده مثلا التهاب الكبد الوبائي B أو
+
+151
+00:14:07,050 --> 00:14:13,340
+Cالـ Malaria المش عارف، هذه أمراض كذا ثبت إن إنسان
+
+152
+00:14:13,340 --> 00:14:18,600
+عنده هذا المرض فبالقانون بالقانون التابعة الصحة
+
+153
+00:14:18,600 --> 00:14:24,360
+هناك تعريف للأمراض التي يجب أن تبلغ عنها هو طبعا
+
+154
+00:14:24,360 --> 00:14:28,300
+يعني عادة مش الطبيب اللي ببلغ بس عادة حتى المختبر
+
+155
+00:14:28,300 --> 00:14:33,860
+في نظام يقول في المختبر إنه لما تكون الحالة
+
+156
+00:14:33,860 --> 00:14:39,430
+الفلانية هي اللي تم تشخيصها يتم التبلغ والسببحتى
+
+157
+00:14:39,430 --> 00:14:43,410
+لو الإنسان أراد أو لم يرد هناك واجب للمجتمع يحمي
+
+158
+00:14:43,410 --> 00:14:50,870
+المجتمع إنه مرته وولاده جيرانه يمكن شخص مخالط له
+
+159
+00:14:50,870 --> 00:14:55,990
+بدك تفحص بدك تشوفه بدك تحميه بدك تنبهه إنه يعني
+
+160
+00:14:55,990 --> 00:15:00,970
+داخل على حالة مرض يعني مثلا ممكن نقول حتى لو الـ
+
+161
+00:15:00,970 --> 00:15:04,670
+COVID تبعنا في الأيام الحياة هذه يعني بعض الناس
+
+162
+00:15:04,670 --> 00:15:12,780
+إذا أصيبممكن يعني أكبر مثال هذا يعني رئيس الولايات
+
+163
+00:15:12,780 --> 00:15:16,920
+المتحدة الأمريكية مهمل للموضوع مش مصدق إنه هذا
+
+164
+00:15:16,920 --> 00:15:22,340
+مرضه بيخوف وكده لا بديه بس كان معمل ومهمل وعشان هي
+
+165
+00:15:22,340 --> 00:15:25,200
+كل اللي حواليه كتير منهم هو انصاب وغير انصاب
+
+166
+00:15:25,200 --> 00:15:32,260
+انتصيبوا فهناك قوانين للصحة الواحد يجب أن يعرف ما
+
+167
+00:15:32,260 --> 00:15:37,300
+هي هذه القانون اللي بحكمنييعني لو في لحظة معينة في
+
+168
+00:15:37,300 --> 00:15:41,400
+مثلًا إنه قانون للصحة وقانون لنقابة الأطباء أو
+
+169
+00:15:41,400 --> 00:15:47,160
+نظام لنقابة الأطباء أظن وفيه إلاج وتعليمات يجب أن
+
+170
+00:15:47,160 --> 00:15:53,520
+الواحد ينتبه للمسميات هذه ويشوف هو في التعامل مع
+
+171
+00:15:53,520 --> 00:15:58,560
+الصحة في مكانه ما الذي ينطبق عليه شوف قانوني
+
+172
+00:15:58,560 --> 00:16:02,320
+القانون الصحي التابعي بالزمن بماذا وهذه القضية
+
+173
+00:16:02,320 --> 00:16:06,900
+بدأت تكون واضحةفتمّى لأن الموضوع واضح هنا قانون
+
+174
+00:16:06,900 --> 00:16:14,300
+الصحة في أسئلة؟
+
+175
+00:16:14,300 --> 00:16:18,640
+تمام يا دكتور ما في حد سأله الله يرضى عليك المبدأ
+
+176
+00:16:18,640 --> 00:16:25,720
+التاني مبدأ مبادئ حقوق الإنسان بالذات سنة 1948
+
+177
+00:16:25,720 --> 00:16:34,260
+اتفق العالم يعنيأحنا خصوصيتنا أحنا مسلمين أحنا عرب
+
+178
+00:16:34,260 --> 00:16:39,960
+أحنا في دولة الأردن أو في دولة فلسطين ومنطقة الشرق
+
+179
+00:16:39,960 --> 00:16:49,680
+الأوسط وعنا مبادئ معينة ولكن يعني وهناك يعني مبادئ
+
+180
+00:16:49,680 --> 00:16:56,920
+ضمنا تعتبر كل البلاد الموقع عليها مشتركة فيها اللي
+
+181
+00:16:56,920 --> 00:17:04,190
+هي مبادئ حقوق الإنسانوهذه أنا في 99% منها لا
+
+182
+00:17:04,190 --> 00:17:07,570
+أعتبرها وعلى أكثر أعتبر الإسلام هو اللي بيدعى لها
+
+183
+00:17:07,570 --> 00:17:12,350
+يعني لما تسمع مقولة سيدنا عمرو اللي خطاب «ما
+
+184
+00:17:12,350 --> 00:17:16,530
+تستعبدتم الناس وقد ولدتهم أمهاتهم أحرارة» يعني
+
+185
+00:17:16,530 --> 00:17:21,670
+مبادع حقوق الإنسان لمجرد إنه إنسان عربي، مسلم،
+
+186
+00:17:21,670 --> 00:17:28,360
+هندي، تعتبره أسود، أبيض، شلعرفيعني حتى دائما يُذكر
+
+187
+00:17:28,360 --> 00:17:34,660
+أنه على مدخل جامعة «هارفرد» يقول لك ذكر سيدنا محمد
+
+188
+00:17:34,660 --> 00:17:39,440
+صلى الله عليه وسلم أنه لا أفضل عربي على عجمي ولاد
+
+189
+00:17:39,440 --> 00:17:44,440
+أو على أبيض على أسود إلا بالتقوى، ناشي؟ فهناك
+
+190
+00:17:44,440 --> 00:17:48,180
+مبادئ لحقوق الإنسان حقه في الحياة، حقه في الصحة،
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+191
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+192
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+
+193
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+لحقوق الإنسان وهذا يعني ما تم التوافق عليه وأنا
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+194
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+195
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+196
+00:18:15,910 --> 00:18:21,350
+الشخص اللي أمامك النازيين
+
+197
+00:18:21,350 --> 00:18:28,320
+الألمان الحرب العالمية التانية أو قبلهاكان عندهم
+
+198
+00:18:28,320 --> 00:18:33,800
+يعني حقيقةً تجاوزات شديدة جداً في الناحية يعني
+
+199
+00:18:33,800 --> 00:18:38,820
+العلم ما بين الحربين العالميين كان أكتر مكان متقدم
+
+200
+00:18:38,820 --> 00:18:44,960
+فيه بالعالم الألمان فالألمان بالفكرة النازي عندهم
+
+201
+00:18:44,960 --> 00:18:50,540
+قضية تفوق العرق الآلي بسمهم يعني أنه الألمان أحسن
+
+202
+00:18:50,540 --> 00:18:55,270
+من غيرهموإنه لمجرد إنك أنت ألماني لمجرد إنك أنت
+
+203
+00:18:55,270 --> 00:19:00,250
+أسود أو أبيض أبيض على أسود تعتبر إنه من حقه يعمل
+
+204
+00:19:00,250 --> 00:19:05,290
+أي شيء فكانوا يقتلوا المتخلفين عقلياً مش بس اليهود
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+205
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+206
+00:19:09,690 --> 00:19:16,660
+يعني إذا بيعتبروا كان عندهم تصنيف للبشراليهود أدنى
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+207
+00:19:16,660 --> 00:19:20,640
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+يعني احنا مش بعيدين عنهم، كانت اسياق سيئة فعمله
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+209
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+210
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+211
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+212
+00:19:40,880 --> 00:19:46,430
+أن واحد يعمل تجارب على إنسان مججون؟ لايعني لا
+
+213
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+يوافق لك بحريته أو هل مثلا أنا جاء أقول لو واحد
+
+214
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+بدنا نعدمه واتفقنا على إن عقوبة الإعدام والله
+
+215
+00:19:54,750 --> 00:19:58,510
+اشترك لبقى التجربة ويمكن تموت فيها بس نعفيك من
+
+216
+00:19:58,510 --> 00:20:04,410
+عقوبة الإعدام مثلا يعني هناك قانون ومبادئ يعني
+
+217
+00:20:04,410 --> 00:20:11,740
+خصيصة للأبحاث الطبيةالاعتفاق الهيلسينكي بيسموها
+
+218
+00:20:11,740 --> 00:20:18,460
+يعني بالذات لما انتهت الحرب العالمية التانية كانت
+
+219
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+يعني صيدوا وأثروا الأطباء والعلماء الألمان اللي
+
+220
+00:20:25,060 --> 00:20:30,220
+أجروا تجارب بالذات اليهود وكان التجارب يعني علمياً
+
+221
+00:20:30,220 --> 00:20:33,780
+من أدق التجارب من أفضل التجارب استفدنا منها كتير
+
+222
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+223
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+حياته أنه يعني إذا مثلا بعرف الواحد في مرض اسمه
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+224
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+مرض ويجنر ويجنر-granulomatosis هذا ويجنر عالم
+
+225
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+
+226
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+
+227
+00:21:00,440 --> 00:21:06,380
+من الذين حُكموا في محاكمات Nuremberg هذه محاكمات
+
+228
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+230
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+
+233
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+وتتعامل مع المريض لمصلحت هذا المريض لما أنت بدك
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+234
+00:21:38,690 --> 00:21:42,730
+تعمل بحث أنت ما بتفوي الشغل لأنك عارف أنك أنت
+
+235
+00:21:42,730 --> 00:21:48,350
+بتعالج هذا المريض إنما أنت تعمل التجربة عشان تفيد
+
+236
+00:21:48,350 --> 00:21:54,110
+المجتمع عشان تفيد البشرية فبالتالي الأبحاث الطبية
+
+237
+00:21:55,070 --> 00:22:02,650
+منها إنه لازم البحث يأخذ مؤافقة اللي يسموه IRB الـ
+
+238
+00:22:02,650 --> 00:22:08,290
+Institutional Review Board يعني لجنة تقييم
+
+239
+00:22:08,290 --> 00:22:14,050
+أخلاقيات البحث هل هذا البحث يعني أنا إذا بعمل
+
+240
+00:22:14,050 --> 00:22:18,470
+تجربة وما لهاش قيمة علمية حرام، ليش أعملها؟ لازم
+
+241
+00:22:18,470 --> 00:22:23,080
+يكون إن فيه قيمة علميةومش الباحث نفسه اللي بيقرر
+
+242
+00:22:23,080 --> 00:22:25,960
+إنه هي إلى قيم علمية غيره لازم نقوله «أه والله
+
+243
+00:22:25,960 --> 00:22:29,620
+باحثك هذا كويس، اعمله» يعني أنا بتيجي إن استشارات
+
+244
+00:22:29,620 --> 00:22:32,860
+مثلا مرات إنه شو رايك؟ وانا والله عندي كده، بدي
+
+245
+00:22:32,860 --> 00:22:37,340
+أعمل كده، نعمل ولا ما نعملش، غيره لازم نقول غير
+
+246
+00:22:37,340 --> 00:22:40,860
+الباحث، الباحث دي ممكن بده شهرة، بده يجيب بصاري،
+
+247
+00:22:40,860 --> 00:22:45,840
+بده كده، بعمل الشغل، فبالتالي الأبحاث الطبية اللي
+
+248
+00:22:45,840 --> 00:22:50,220
+لها مبادئ وبده الواحد لما يشتغل فيهايكون عارف شو
+
+249
+00:22:50,220 --> 00:22:56,880
+هي المبادئ ويتطبقها ويتعامل معاها الحاكم
+
+250
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+الرابع لتعامل الواحد هي قضية أنا بشتغل في مؤسسة
+
+251
+00:23:02,720 --> 00:23:07,340
+يعني أنا بشتغل في جامعة العلوم التكنولوجية
+
+252
+00:23:07,340 --> 00:23:11,640
+الأردنية موظفة فيها وفي مستشفى الملك المؤسس في
+
+253
+00:23:11,640 --> 00:23:17,220
+«أربد» أو في «الرامطة» الشمال للأردن فالمؤسسة
+
+254
+00:23:17,220 --> 00:23:22,930
+أنا تعقدت معاهاففقعت عقد إذا ما التزمت أنا بالعقد
+
+255
+00:23:22,930 --> 00:23:27,930
+حقهم يعقبوني و أحياناً يعني في محددات حتى إضافية
+
+256
+00:23:27,930 --> 00:23:31,910
+غير المبادئ القانونية العامة من المؤسسة التابعتها
+
+257
+00:23:31,910 --> 00:23:36,730
+إذا ما التزمت فيها أنت مش ناجح أنت مش يعني مخدد
+
+258
+00:23:36,730 --> 00:23:40,890
+يعني مش مش أنت علاج سبب في التأخر سبب في التخلق
+
+259
+00:23:40,890 --> 00:23:45,890
+سبب في النزاع سبب في الشفاق الأصل أنه أنا أكون
+
+260
+00:23:45,890 --> 00:23:50,290
+عارفشو نظام المؤسس اللي أنا بشتغل فيه وإني وافقت
+
+261
+00:23:50,290 --> 00:23:56,490
+عليه وبتعامل معاه يعني صراحة من أجمل الأمثلة ومش
+
+262
+00:23:56,490 --> 00:24:00,430
+غلط الواحد دايما يذكر الخير لأهله أنا روحت على
+
+263
+00:24:00,430 --> 00:24:05,530
+أمريكا بالـ 91 وأول مرة يعني أنا كنت في الكويت
+
+264
+00:24:05,530 --> 00:24:09,390
+وإنا أتجارب في مجتمع قريب من غزة في الكويت كيف
+
+265
+00:24:09,390 --> 00:24:13,790
+الناس بتتعامل مرات كتير في أشياء كتيرة إحنا عندنا
+
+266
+00:24:13,790 --> 00:24:20,500
+في بلادنابتروح بتأمن سيارة، بتروح بتتوظف في مكان،
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+267
+00:24:20,500 --> 00:24:25,320
+ولمّا ودّوني بقيت، هل بتتعامل مع بنك تأخذ قرن،
+
+268
+00:24:25,320 --> 00:24:28,880
+بيبعتوك صفتة الأوراق والمسئول بيقول لك وقّع هون
+
+269
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+وقّع هون وقّع هون وقّع هون وقّع هون وانت مش فقار
+
+270
+00:24:32,180 --> 00:24:36,440
+ومش فاهم ومش عامل أيش، فاهم عليك؟ انت ملزم وخلاص
+
+271
+00:24:36,440 --> 00:24:41,280
+وقّع، والله لما كنت في أمريكا أول ما اشتغلت في
+
+272
+00:24:41,280 --> 00:24:46,980
+المستشفى وانا بوقع العقد معهماللي انضميت لهم عطوني
+
+273
+00:24:46,980 --> 00:24:54,760
+ليست أوراقها القدّي حقوقي وواجباتي بشكل تفصيلي شو
+
+274
+00:24:54,760 --> 00:24:59,700
+لازم أعمل وكيف أتصرف طبعا يمكن الواحد أولها ماكانش
+
+275
+00:24:59,700 --> 00:25:04,260
+فاهم كتير بس فعلا بقلال تعاملي معهم فعلا برجع
+
+276
+00:25:04,260 --> 00:25:13,780
+للمبادئ هذه وعقدت أخيرا إحنا مسلمينحقيقةً النظام
+
+277
+00:25:13,780 --> 00:25:21,220
+الإسلامي هو أرقى وأفضل وأعلى نظام يعني بشري أنا
+
+278
+00:25:21,220 --> 00:25:25,380
+عشان هيك بقول مثلا مبادئ حقوق الإنسان ومبادئ
+
+279
+00:25:25,380 --> 00:25:29,360
+العالمية بفهمها في ضوء الإسلام هذا قرار الشخصي
+
+280
+00:25:29,360 --> 00:25:35,360
+اللي بسميه بس يعني أنا بشوف إنها كثير متوافقة مع
+
+281
+00:25:35,360 --> 00:25:40,850
+مبادئ الدين الإسلاميومنظمة إله والواحد يتذكر إنه
+
+282
+00:25:40,850 --> 00:25:46,890
+في الدنيا مش لوحده يعني ممكن بسهولة الإنسان يسافر
+
+283
+00:25:46,890 --> 00:25:52,090
+يكون حتى في سفره يدخل في بلاد تانية بدي يكون البشر
+
+284
+00:25:52,090 --> 00:25:57,310
+يعني وغير ذلك تكون الحياة غابة القوية أكلت ضعيفك
+
+285
+00:25:57,310 --> 00:26:01,770
+بغير يعني بتعدي أو ضلم
+
+286
+00:26:05,210 --> 00:26:10,550
+الإسلام يعني من الأشياء اللي يجب كمسلم وعربي يكون
+
+287
+00:26:10,550 --> 00:26:14,430
+الواحد واضح عنده بالذات في الأمور بين قوسين
+
+288
+00:26:14,430 --> 00:26:21,950
+الفقهية يعني الدين، ديننا، في أشياء علوم غيبية إذا
+
+289
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+واحد بيقول مافيش آخرة ومش حاسب أسابي الآخر وفي جن
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+290
+00:26:25,850 --> 00:26:30,410
+ونار، هو حر طبعا هذا الجانب ربنا اللي بعرفه، يعرف
+
+291
+00:26:30,410 --> 00:26:36,280
+شو قلب الواحدوشو يعني جوا وفكري الواحد وليش الواحد
+
+292
+00:26:36,280 --> 00:26:40,660
+بيستوي هذا الموضوع بس في الأمور الفقهية الفقهية
+
+293
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+لما نقول فقه يعني هذا من المبادئ الجميلة أنا أمين
+
+294
+00:26:45,180 --> 00:26:48,560
+سير جمعية العلم الطبية الإسلامية في نقاط الأطباء
+
+295
+00:26:48,560 --> 00:26:53,580
+الوردنية الفقه
+
+296
+00:26:53,580 --> 00:26:59,930
+هو الجانب العملي من العبادات ومن المبادئيعني
+
+297
+00:26:59,930 --> 00:27:06,790
+الجوانب العملية كيف تصلي، كيف تصوم، أي فقه كيف
+
+298
+00:27:06,790 --> 00:27:13,410
+تتزوج، كيف تطلق، أي فقه كيف مثلا تبيع وتشتري، فقه
+
+299
+00:27:13,410 --> 00:27:19,090
+لأنه أمور عملية مش علوم غيبية أو علوم يعني فكرية
+
+300
+00:27:19,090 --> 00:27:25,310
+مطلوبة من الإنسان والإيمان مطلوب وضروري على الأقل
+
+301
+00:27:25,310 --> 00:27:30,320
+إيمان من الجنة والنار والحساب والإيقافففي القيقه
+
+302
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+يقال هناك فيه مقاصد وقواعد المقاصد يجمعها قضية
+
+303
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+مهمة هي الضرورات الخامسة يعني إحنا لما نتعامل
+
+304
+00:27:43,680 --> 00:27:50,700
+الإسلام بينظر ضرورة المحافظة على الدين على الحياة
+
+305
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+أو النفس على العقل على العرض وعلى المال والحقوق
+
+306
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+ماشي، فهذه مقاصد الشريعة الإسلام يقول لك ما بجزء
+
+307
+00:28:04,710 --> 00:28:08,950
+منك تأخذ الفلس من بني آدم آخر إذا ما هو راضي وعن
+
+308
+00:28:08,950 --> 00:28:16,630
+طيب خاطر وعن قناعه، غير هيك إذا ما يعني فهذه مقاصد
+
+309
+00:28:16,630 --> 00:28:21,370
+الشريعة للحفاظ على هذه الأمور والحفاظ على الصحة هو
+
+310
+00:28:21,370 --> 00:28:28,340
+من مقاصد الحفاظ على الحياةفالـ يعني يكفي الإنسان
+
+311
+00:28:28,340 --> 00:28:35,480
+فقر إن الله سبحانه وتعالى في يعني بعد ذكر قصة أبيل
+
+312
+00:28:35,480 --> 00:28:40,320
+وأبيل في القرآن الكريم يعني بيدكر من أجل ذلك كتبنا
+
+313
+00:28:40,320 --> 00:28:46,000
+على بني إسرائيل أنه من قتل نفسا بغير نفسه فكأنه
+
+314
+00:28:46,000 --> 00:28:49,920
+فكأنه ما قتل الناس جميعه ومن أحياه فكأنه ما أحيى
+
+315
+00:28:49,920 --> 00:28:54,160
+الناس جميعها أظن أني ممكن خربطت الآية شوية بس ومن
+
+316
+00:28:54,160 --> 00:28:59,750
+أحياهفكأنما أحيى الناس جميعًا يعني يوم من قتل
+
+317
+00:28:59,750 --> 00:29:02,790
+الهبيل يعني الواحد يقول نص البشرية ربع البشرية
+
+318
+00:29:02,790 --> 00:29:09,370
+ماتت الواحد يعني ينقل حياة إنسان هذا من مقاصد
+
+319
+00:29:09,370 --> 00:29:14,770
+الشرق الأساسية فهناك مقاصد يجب أن يفهمها الواحد
+
+320
+00:29:14,770 --> 00:29:20,410
+ينظر في التراث الإسلامي ومبادئ العظيمة من القرآن
+
+321
+00:29:20,410 --> 00:29:24,210
+الكريم القرآن يعني
+
+322
+00:29:25,410 --> 00:29:32,510
+يعني هو رسالة الله إلى البشرية الخالدة الرسالة
+
+323
+00:29:32,510 --> 00:29:38,670
+يعني أنا بحكي كثير للأصدقاء اللي كنا في أمريكا وفي
+
+324
+00:29:38,670 --> 00:29:45,010
+دول تانية مؤتمرات أو غيره أنه اللي لما نحنا نتكلم
+
+325
+00:29:45,010 --> 00:29:51,710
+عن القرآن الانجليزي نفسهم انجليزي شيكسبير اللي هو
+
+326
+00:29:51,710 --> 00:29:57,520
+عاش قبل 400 سنة بسوتعطيهم الكلام اللي ذكره شيكسبير
+
+327
+00:29:57,520 --> 00:30:03,040
+نفسه لا يفهموه فطبعا التوراة والإنجيل ما حد بيقدر
+
+328
+00:30:03,040 --> 00:30:05,980
+يقول أنه الآن اللي بين إيديهم توراة وإنجيل هي
+
+329
+00:30:05,980 --> 00:30:10,120
+توراة وإنجيل اللي نزلت على سيدنا موسى وعيسى عليه
+
+330
+00:30:10,120 --> 00:30:15,080
+السلام بينما القرآن الكريم محفوظ بحفظ الله سبحانه
+
+331
+00:30:15,080 --> 00:30:20,260
+وتعالى وكذلك كثير من السنة النبوية محفوظة ولغتها
+
+332
+00:30:20,260 --> 00:30:24,830
+محفوظة وثابتة إلى يوم القيامةهذه حقيقة المعجزة
+
+333
+00:30:24,830 --> 00:30:30,230
+الإسلام إنه يعني شغل ما تغيرت طيل هذا السنين
+
+334
+00:30:30,230 --> 00:30:36,770
+والعقود وألاف السنين وهي ثابتة لا تتغير عندما تتلو
+
+335
+00:30:36,770 --> 00:30:40,730
+القرآن الكريم فانت تتلوه كما تلاه سيدنا محمد صلى
+
+336
+00:30:40,730 --> 00:30:45,050
+الله عليه وسلم في لغة قبل ذلك اتثرت قبل 200 سنة من
+
+337
+00:30:45,050 --> 00:30:51,090
+الإسلام فمقاصد الشرق المفروض الواحد يتنبهها إلها
+
+338
+00:30:51,090 --> 00:30:58,570
+وقواعدهناك قواعد شرعية في الفقه، قواعد فقهية كأنا
+
+339
+00:30:58,570 --> 00:31:05,050
+كنا في دورات فقهية الصراحة يعني فيها بيات شعر
+
+340
+00:31:05,050 --> 00:31:12,210
+جميلة جدا ذُكرت لنا في حفظتها، وأذكركم إياها
+
+341
+00:31:12,210 --> 00:31:20,110
+أحدهم، نسيت العالم اللي ذكرها، يقولخمس مقررة قواعد
+
+342
+00:31:20,110 --> 00:31:27,770
+مذهب للشافعية فكن بهنا علينا خمس قواعد وهي جملة
+
+343
+00:31:27,770 --> 00:31:32,650
+تعطي قاعدة تنطبق على مسائل الفقهية كثيرة حتى
+
+344
+00:31:32,650 --> 00:31:38,950
+الواحد يحكم خمس مقررة قواعد مذهب للشافعية فكن بهنا
+
+345
+00:31:38,950 --> 00:31:43,970
+علينا الإمام الشافعي رضي الله عنه كان من أهم
+
+346
+00:31:43,970 --> 00:31:49,660
+المؤثرين للفقهوأصول الفتاة وأصول الدين غيرها من
+
+347
+00:31:49,660 --> 00:31:54,460
+المبادر حقيقة الإنسان عظيم فالإمام الشافعي هذا
+
+348
+00:31:54,460 --> 00:31:58,320
+اللي بقوله عن الإمام الشافعي عنده خمس قواعد ضرر
+
+349
+00:31:58,320 --> 00:32:04,200
+يزال وعادة قد حُكمت وكذا المشاقة تجلب التيسيرة
+
+350
+00:32:04,200 --> 00:32:12,960
+والشك لا تحفع به متيطنا وقصد أخلص إن أردت أجورة هو
+
+351
+00:32:12,960 --> 00:32:19,860
+قواعده اللي هي أنهفي الفقه والشرع والدين أولاً أنه
+
+352
+00:32:19,860 --> 00:32:24,100
+لا ضرر ولا درار وحتى في كتابكم الآن حيجيب يقولك لا
+
+353
+00:32:24,100 --> 00:32:28,660
+ضرر ولا درار يعني هناك طبعاً قواعد سرعية هي قواعد
+
+354
+00:32:28,660 --> 00:32:32,740
+الكلية كما يقال يعني دائماً من القواعد الفقهية
+
+355
+00:32:32,740 --> 00:32:39,490
+تقال أحياناً دفع الضرر مقدم على جانب المنفعوالله
+
+356
+00:32:39,490 --> 00:32:47,250
+أنا حرام بدي أجيب مروحة أحطها عليّ وأنا عشاني حرام
+
+357
+00:32:47,250 --> 00:32:51,050
+ييجي واحد بس أنا حرام شوية يعني مش مشكلة مش ضارة
+
+358
+00:32:51,050 --> 00:32:57,610
+كبيرة فينما اللي جنبي عنده رشحة ولا عنده مرض فهويت
+
+359
+00:32:57,610 --> 00:33:03,490
+عليه المروحة هذه القضية تجلب له مرض فعندها لأ
+
+360
+00:33:03,490 --> 00:33:08,310
+بنقول بنطفل المروحة بنضويهاش لأنهدفع المضارة مقدّم
+
+361
+00:33:08,310 --> 00:33:13,490
+على جلب المنطقة في هذه الطريقة فضرر يزالي وهذا في
+
+362
+00:33:13,490 --> 00:33:19,050
+حديث الرسول ﷺ لا ضرر ولا ضرار ويعني من المبادئ إنه
+
+363
+00:33:19,050 --> 00:33:24,710
+لا ضرر ولا ضرار بعدين وعادة قد حُكّم إذا الناس
+
+364
+00:33:24,710 --> 00:33:31,670
+اتفقوا على عاد معين وما في لها مخالفة شرعية الأمر
+
+365
+00:33:31,670 --> 00:33:37,520
+يعني يُلتفت له ويُحكمالإمام الشافعي كان بالعراق
+
+366
+00:33:37,520 --> 00:33:42,000
+كان يحكم الطريقة ويفت الطريقة راح على مصر صار يفت
+
+367
+00:33:42,000 --> 00:33:45,300
+الطريقة تاني قالوله يا شيخ أنت في العراق كنت تفت
+
+368
+00:33:45,300 --> 00:33:49,880
+فت هيك قالت آه كنا في وضع وكانت فت هيك صرنا في وضع
+
+369
+00:33:49,880 --> 00:33:54,320
+آخر بنفت الطريقة اللي حسبناها يعني أنا مثلا مشهورة
+
+370
+00:33:54,320 --> 00:34:00,460
+من الشغلات اللي نذكرها مثلا الـ Jesus عندنا في
+
+371
+00:34:00,460 --> 00:34:07,790
+فلسطين والأردن وكذاودول كثيرة معروف الذلمي بتدفع
+
+372
+00:34:07,790 --> 00:34:13,830
+كل إشي البيت والشقة والأثات والمهر وكذا الذلمي
+
+373
+00:34:13,830 --> 00:34:18,770
+بتدفع كل إشي هيك عادت الناس والواحد هو حظه الذلمي
+
+374
+00:34:18,770 --> 00:34:28,730
+بده يدفع إذا زوجة بتدفنها أما في مصر معروف الشقة
+
+375
+00:34:28,730 --> 00:34:35,020
+على الذلمي والأثات على المرأةخلاص هي عادة الناس
+
+376
+00:34:35,020 --> 00:34:40,000
+وعرفهم إنهم بيعملوا هيك مدام متفقين عليه في الشرع
+
+377
+00:34:40,000 --> 00:34:44,580
+وفي الدين هذا يصبح أصل شرعي وعادة قد حُكّمه فيجب
+
+378
+00:34:44,580 --> 00:34:49,940
+القاضي ولا كده يحكم حسب عرفه في آية في القرآن وأمر
+
+379
+00:34:49,940 --> 00:34:53,400
+بالعرف العرف ما تعرف عليه الناس حتى ما يصير خلاف
+
+380
+00:34:53,400 --> 00:35:00,020
+مايصير مشاكل وعادة قد حُكّمهوكذا المشاقة تجلب
+
+381
+00:35:00,020 --> 00:35:04,260
+التيسيرة في الشرق والدين اللي عايش كل ما ضاقت
+
+382
+00:35:04,260 --> 00:35:10,720
+انفرجت والله أنا مريض كنت تصلي مطلوب منك تقوم تسير
+
+383
+00:35:10,720 --> 00:35:16,380
+تقعد تقعد كنت كذا تعمل كذا كل ما هناك مشاقة من فضل
+
+384
+00:35:16,380 --> 00:35:23,500
+الله علينا جعلنا تيسير والشك لا تنقض به متيقنا
+
+385
+00:35:23,500 --> 00:35:31,250
+يعني الشك اليقين يغلب الشكماشي فإذا أنا والله
+
+386
+00:35:31,250 --> 00:35:37,710
+اتوضيت شكيت أنا متأكد إن اتوضيت وشكيت إن أنا نقطت
+
+387
+00:35:37,710 --> 00:35:41,410
+الوضوء ولا ما قطتش إذا مش متأكد إن أنا نقطت الوضوء
+
+388
+00:35:41,410 --> 00:35:46,010
+خلاص وضوء جاهز كامل وغض النظر ما يوثوث في الواحد
+
+389
+00:35:46,010 --> 00:35:51,130
+ده حالة وقضية إنما الأعمال بالنيات وهذا من كبار
+
+390
+00:35:51,130 --> 00:35:55,710
+الأحاديث وعليها أشياء كثيرة إنه النية في العمل هي
+
+391
+00:35:55,710 --> 00:36:01,820
+الأساسولا قصد أخلص إن أردت أجورة اللي هي مبدأ أو
+
+392
+00:36:01,820 --> 00:36:06,820
+قاعدة إنما الأعمال بنفسها فهذه حقيقة يعني الجانب
+
+393
+00:36:06,820 --> 00:36:11,080
+اللي ما حد يعني أردت أوضيحه بزيادة عن ما ذُكر في
+
+394
+00:36:11,080 --> 00:36:16,400
+الكتاب والكتاب بيركز على ال effects تبعات
+
+395
+00:36:16,400 --> 00:36:23,740
+الأخلاقيات الطبية للدراسة الوراطية علم الوراطة
+
+396
+00:36:23,740 --> 00:36:28,860
+وعلم ال genomics وغيرها من الأشياء العاديةفبعد هذه
+
+397
+00:36:28,860 --> 00:36:32,600
+المقدمة يعني
+
+398
+00:36:32,600 --> 00:36:35,640
+في
+
+399
+00:36:35,640 --> 00:36:41,420
+جزء أنا بعتبر أنه مهم جدا أيضا من ناحية كتابكم
+
+400
+00:36:41,420 --> 00:36:48,320
+قضية إن هناك أربع مبادئ تحكم أخلاقيات التعامل مع
+
+401
+00:36:48,320 --> 00:36:52,860
+الوراتة وعلم الوراتة وقرصات الوراتة وأمراض الوراتة
+
+402
+00:36:52,860 --> 00:37:01,760
+وغيرهاالمبادئ هذه أولاً وطبعاً هتشوفها في يعني من
+
+403
+00:37:01,760 --> 00:37:08,760
+مبادئ سواء حقوق الإنسان العالمية حقوق الأبحاث
+
+404
+00:37:08,760 --> 00:37:13,120
+وأخلاقيات الأبحاث وغيرها من قسم الطبيب وغيرها
+
+405
+00:37:13,120 --> 00:37:18,460
+وغيرها أولاً يعني هناك أربع مبادئ أولاً Respect
+
+406
+00:37:18,460 --> 00:37:22,200
+for individual autonomySafeguarding an
+
+407
+00:37:22,200 --> 00:37:25,280
+individual's right to control his or her medical
+
+408
+00:37:25,280 --> 00:37:30,380
+care and medical information free of coercion يعني
+
+409
+00:37:30,380 --> 00:37:37,520
+أنه أنت مطالب بالمحافظة على استقلالية الفرد الذي
+
+410
+00:37:37,520 --> 00:37:43,040
+أمامك بالذات يعني هنا إحنا بيحط حريتك كما يتقال في
+
+411
+00:37:43,040 --> 00:37:46,760
+الأمثلة تنتهي عندما تبدأ حرية الآخرين
+
+412
+00:37:49,430 --> 00:37:59,410
+فالإنسان حر ويعني بأموره الشخصية ماشي وبالذات في
+
+413
+00:37:59,410 --> 00:38:06,270
+جسده ما تستطيع تجبره أو تتعدى على حريته وعلى
+
+414
+00:38:06,270 --> 00:38:13,690
+استقلاليته في قراراته لأن كل إنسان له مبادئ وله
+
+415
+00:38:13,690 --> 00:38:21,350
+يعني ما يعتبره ثمين لديهحق كل واحد كما أنت ترغب
+
+416
+00:38:21,350 --> 00:38:25,630
+يعني عامل الناس كما تحب أن يعاملوه لا تريد منهم
+
+417
+00:38:25,630 --> 00:38:33,710
+يعني أنه يجبروك على شيء أنت لا ترغبه، ناشي؟ فالحق
+
+418
+00:38:33,710 --> 00:38:38,170
+الإنسان في التصرف بجسمه، حق الإنسان يعني هذه قضية
+
+419
+00:38:38,170 --> 00:38:43,700
+إنه أنا جسمي ملكي، لأ مش ملكك للبيعبس أنا اللي
+
+420
+00:38:43,700 --> 00:38:48,100
+بتتصرف فيه ولاجب أنه يعني لما أي مريض يدخل
+
+421
+00:38:48,100 --> 00:38:52,960
+المستشفى الأصل يوقّع تفويت للمستشفى خطيه بس إذا
+
+422
+00:38:52,960 --> 00:38:57,200
+بده عملية لازم يوقّع إنه موافق على العملية إذا
+
+423
+00:38:57,200 --> 00:39:01,780
+الإنسان مابدوش وافق لأ مابتجبره تجبره وإذا بتعرف
+
+424
+00:39:01,780 --> 00:39:06,960
+إن الإنسان عنده يعني مفاهيم معينة في حقوقه بشكل
+
+425
+00:39:06,960 --> 00:39:14,300
+معين لأ بدك تطبقها حتى لو بموتيعني من الأمثل
+
+426
+00:39:14,300 --> 00:39:19,280
+المشهورة في طائفة من المسيحيين إيه بيسموهم شهود
+
+427
+00:39:19,280 --> 00:39:23,720
+يهوة باللغة العربية Jehovah Witnesses باللغة
+
+428
+00:39:23,720 --> 00:39:30,760
+الإنجليزية هذولة ناس مجموعة بصراحة لطيفين جدا
+
+429
+00:39:30,760 --> 00:39:36,420
+ومتدينين والله يهديهم إنه حد يشرح لهم الإسلام بشكل
+
+430
+00:39:36,420 --> 00:39:42,770
+جيد هذولة عندهم نقل الدم والأعباء حرفيعني كأن
+
+431
+00:39:42,770 --> 00:39:49,770
+تيجيك واحدة و لا تنزف و لا من حمل و لا تيجيك واحدة
+
+432
+00:39:49,770 --> 00:39:56,830
+منهم عندها مثلا دم ضعيف جدا و أنت اللي بتعرفه أنه
+
+433
+00:39:56,830 --> 00:40:02,610
+لازم تنقض حياتها بنقل الدم الله لو أنا ثبت عندي
+
+434
+00:40:02,610 --> 00:40:06,730
+أنه أنا بعالج إنسان هو من هذه الطائفة و هذه الشغل
+
+435
+00:40:06,730 --> 00:40:14,100
+عندهمهمة إنه لا يقبل نقل دم فخلاص، بدي التزن،
+
+436
+00:40:14,100 --> 00:40:19,660
+ماشي؟ respect for individual autonomy beneficence
+
+437
+00:40:19,660 --> 00:40:25,340
+حتى دورت مبارح عشان أجيب معناها بالعربي doing good
+
+438
+00:40:25,340 --> 00:40:32,120
+بمعنى الإحسان عمل الخير، اللي هي يعني أن تحسن
+
+439
+00:40:33,040 --> 00:40:37,060
+الإحسان والتقوى يعني أنك تراقب الله في أنك ماتز
+
+440
+00:40:37,060 --> 00:40:41,200
+بالإنسان اللي أمامك دايماً تعمل خير وطول قصدك تعمل
+
+441
+00:40:41,200 --> 00:40:47,640
+خير كقصد avoid يعني ال beneficience اللي هو
+
+442
+00:40:47,640 --> 00:40:54,040
+الإحسان باللغة العربية أن تكون محسن إحسان يعني مش
+
+443
+00:40:54,040 --> 00:40:58,500
+تكافئ الإنسان اللي أمامك لأنه عملك خير لأ أنت تبدأ
+
+444
+00:40:58,500 --> 00:41:04,640
+بأنك تعمل إشي خيروتكون تعمل عملية كافية الشغلة
+
+445
+00:41:04,640 --> 00:41:08,840
+الثالثة Avoidance of Maleficence اللي هو يعني
+
+446
+00:41:08,840 --> 00:41:12,680
+دايما بيقولوا القاعد الأولى في الطب First of all
+
+447
+00:41:12,680 --> 00:41:17,600
+do no harm باللغة الإنجليزية القانون الأول في الطب
+
+448
+00:41:17,600 --> 00:41:24,480
+لا يعني do no harm أي من حتى اللاتينية Primum Non
+
+449
+00:41:24,480 --> 00:41:30,020
+-Nucrilic نوسريلي اللي هي ذلك الله العظيميعني من
+
+450
+00:41:30,020 --> 00:41:34,520
+اللغة اللاتينية من «abocrat» وهي إنه لا تؤذي
+
+451
+00:41:34,520 --> 00:41:37,220
+الإنسان إذا ما تقدرتش تفيده على الأقل أنت ما
+
+452
+00:41:37,220 --> 00:41:43,920
+تتضروش ماشي إذا شاء يعني يعمل أو تدبّى إن هذا يسبب
+
+453
+00:41:43,920 --> 00:41:48,740
+ضرر، يسبب مرض وإذا عملت كذا راح يكون فيه مشكلة
+
+454
+00:41:48,740 --> 00:41:53,300
+المفروض إنك أنت ما تسويها الأمر الأخير أو القاعدة
+
+455
+00:41:53,300 --> 00:41:57,950
+الأخيرة هي قضية العدالة «justice»ensuring that all
+
+456
+00:41:57,950 --> 00:42:01,550
+individuals are treated equally and fairly هذه
+
+457
+00:42:01,550 --> 00:42:05,730
+مبادئ اسلامية يعني الرسول صلى الله عليه وسلم عندما
+
+458
+00:42:05,730 --> 00:42:12,050
+يعني يقول إنما أهلك من كان قبلكم كان إذا سرق
+
+459
+00:42:12,050 --> 00:42:16,570
+الشريف فيهم تركوه وإذا سرق فيهم الضعيف أقاموا عليه
+
+460
+00:42:16,570 --> 00:42:22,590
+الحد عندهم خيار وفقوس ويعني الناس أنواع ودرجات
+
+461
+00:42:22,590 --> 00:42:27,830
+وهذه يعني عيب في أي مجتمعالمفروض تكون يعني مبدأ
+
+462
+00:42:27,830 --> 00:42:34,670
+العدالة يعني أنا مثلا مرات كثيرة تصدف الواحد يجي
+
+463
+00:42:34,670 --> 00:42:40,330
+مرضى طبعا هذه القضايا الأخلاقية بد الواحد ياخد
+
+464
+00:42:40,330 --> 00:42:46,170
+مجمل القواعد كلها ويطبق عليها وهنشوف أنثى لأ أن
+
+465
+00:42:46,170 --> 00:42:50,510
+أحيانا القاعدتين بتضربوا وبالتالي بد الواحد يحكم
+
+466
+00:42:50,510 --> 00:42:57,070
+بينهم وربنا يهديه إلى الفرار الأفضلفالعدالة شغل
+
+467
+00:42:57,070 --> 00:43:06,110
+مطلوبة يعني مثلا كان عندنا يكون مشكلة أن أنت تطالب
+
+468
+00:43:06,110 --> 00:43:10,350
+بتقرير هل هي حالة طارية ولا مش طارية كنا لشغل
+
+469
+00:43:10,350 --> 00:43:15,230
+التأمين، ما تأمينيضطرون نروح على المريض اللي داخل
+
+470
+00:43:15,230 --> 00:43:18,750
+على التأمين في مستشفى خاص المفروض ما راح عليه
+
+471
+00:43:18,750 --> 00:43:25,250
+مريضة شو اسمه؟ نروح نشوف، والله قالولي كانوا
+
+472
+00:43:25,250 --> 00:43:29,790
+بالأول يقولولي إذا الإنسان ما كان بده يموت وفعلا
+
+473
+00:43:29,790 --> 00:43:37,210
+يعني فعلا خالص خالص، هاي كان ممكن يروح على مستشفى
+
+474
+00:43:37,210 --> 00:43:43,240
+الحكومي وبالتالي هي مش طارقةفنروح وفعلا كنت أتطبق
+
+475
+00:43:43,240 --> 00:43:48,000
+هذا الموضوع لو كان واحد جاي تجلطة أو حادث سير و
+
+476
+00:43:48,000 --> 00:43:53,700
+بيزموه على الفوارق في مستشفى وكان مستشفى خاص فخلاص
+
+477
+00:43:53,700 --> 00:43:59,380
+هي طارق لما واحد عنده مثلا حمّة صار لأسبوع ومتعبان
+
+478
+00:43:59,380 --> 00:44:03,020
+ومتعب كتير واخدوه على يعني كان عندهم قرار يعني
+
+479
+00:44:03,020 --> 00:44:07,180
+مجال يودوه على المستشفى كنت بقول هي مش طارق لحد ما
+
+480
+00:44:07,180 --> 00:44:14,740
+يوم من الأيامبجيني الله يرضى عليه كان وزير سابقا
+
+481
+00:44:14,740 --> 00:44:21,580
+يعني وكانت والدته فقاللي يا دكتور أنا هاي والدتي
+
+482
+00:44:21,580 --> 00:44:26,500
+وهي مؤمنة درجة أولى وطبعا والدة وزير وانا بدأ
+
+483
+00:44:26,500 --> 00:44:30,380
+أدخلها بالمكان اللي فلاني عجبك عجبك ماعجبك مش
+
+484
+00:44:30,380 --> 00:44:35,420
+ماعجبك نوصلها للملك ونمشيها غصبا عنها فاتصلت في
+
+485
+00:44:35,420 --> 00:44:38,920
+المسئول عني بقوله هيك هيك هيك الزلمة هذا بيحكيقال
+
+486
+00:44:38,920 --> 00:44:43,800
+يا عمي ما هو وزيره، هاي أمه، خلاص مشيها يعني مش
+
+487
+00:44:43,800 --> 00:44:48,260
+طارقة، مش طارقة، مشيها كنت حاضر، همشيها، بس والله
+
+488
+00:44:48,260 --> 00:44:52,520
+بعد ذلك كل إنسان عنده إشي بيقول تقوللي طارقة و لا
+
+489
+00:44:52,520 --> 00:44:55,280
+مش طارقة، مدام هي طلعت و راحت على الطوارق، هقولكم
+
+490
+00:44:55,280 --> 00:44:59,940
+إنه طارقة، فصرت أمشي كل الناس طارقة، لأنه بحب أعمل
+
+491
+00:44:59,940 --> 00:45:05,160
+الناس بعدالة، لكل الناس عندي سواسية، ما فيه خيار
+
+492
+00:45:05,160 --> 00:45:13,370
+تبكور، فهذه المبادئ الأساسيةالـ هناك يعني بالذات
+
+493
+00:45:13,370 --> 00:45:20,430
+أمور الوراثة مبادئ يعني أو نقاط معينة واضحة ضمن
+
+494
+00:45:20,430 --> 00:45:28,190
+المبادئ اللي حكيناها يعني هل يعني يوافق عليها
+
+495
+00:45:28,190 --> 00:45:33,110
+الواحد ولا لا يوافق فمثلا الـ prenatal diagnosis
+
+496
+00:45:33,110 --> 00:45:40,300
+مثلا قضية الـ non-disease traits أو sex مثلايعني
+
+497
+00:45:40,300 --> 00:45:43,840
+مثلًا من المشهور معروف يقول كيف عيب الدنيا بتتخربط
+
+498
+00:45:43,840 --> 00:45:50,740
+مثلًا في الهند في نقص شديد في النساء سبب بأي
+
+499
+00:45:50,740 --> 00:45:54,260
+مالوسونار من أول ما يبين العضايا التناثلية وإذا
+
+500
+00:45:54,260 --> 00:45:58,780
+أنت بتجهدوها يعني وإذا الموؤودة تسويلت هي دي
+
+501
+00:45:58,780 --> 00:46:03,080
+الموؤودة ماشي يصير الواحد مثلًا يشوف إذا بالذات
+
+502
+00:46:03,080 --> 00:46:07,770
+إذا الشغل مش مرضيعني أنا بدي ابني يطلع طويل، إذا
+
+503
+00:46:07,770 --> 00:46:11,630
+والله طلع قصير وإيه جدرت أدرسها إذا عرفت الـGene
+
+504
+00:46:11,630 --> 00:46:15,010
+على بقى مسئول عن الطيق الطول إذا واحد اللي قصير
+
+505
+00:46:15,010 --> 00:46:20,470
+بديه شيعة بيصير واحد يعني يتخذ إجراءات معينة
+
+506
+00:46:20,470 --> 00:46:24,730
+Testing of asymptomatic adults for genotypes that
+
+507
+00:46:24,730 --> 00:46:29,250
+predispose to late onset diseases يعني هل هذا جائز
+
+508
+00:46:29,250 --> 00:46:32,910
+مش جائز؟Testing asymptomatic children for
+
+509
+00:46:32,910 --> 00:46:36,550
+genotypes that predispose to adult-onset diseases
+
+510
+00:46:36,550 --> 00:46:41,470
+يعني بالذات إنت لما تعمل الفحص هذا، العيش بده كيار
+
+511
+00:46:41,910 --> 00:46:46,610
+ممكن أنا أبحث فيه ممكن واحد من نتاج الدراسات يكون
+
+512
+00:46:46,610 --> 00:46:52,070
+عنده معلومة معينة Secondary
+
+513
+00:46:52,070 --> 00:46:55,410
+findings and the right to not to know about
+
+514
+00:46:55,410 --> 00:46:59,230
+clearly deleterious mutations that will cause
+
+515
+00:46:59,230 --> 00:47:03,330
+disease that could be ameliorated or prevented if
+
+516
+00:47:03,330 --> 00:47:08,890
+the risks were known يعني أحياناً يعني في أشياء
+
+517
+00:47:09,530 --> 00:47:16,150
+يمكن تطلع بشكل ثانوي بس يعني هل حق الإنسان يعرفها؟
+
+518
+00:47:16,150 --> 00:47:22,850
+هل واجب عليها بلغه؟ هل مرات بتكون الأمور مشتبهة؟
+
+519
+00:47:22,850 --> 00:47:29,050
+privacy of genetic information يعني قضية سرية
+
+520
+00:47:29,050 --> 00:47:36,290
+المعلوماتسرية المعلومات من النواحي المهمة في الـ
+
+521
+00:47:36,290 --> 00:47:45,810
+Chats نحكي
+
+522
+00:47:45,810 --> 00:47:51,490
+بالاخر قضية
+
+523
+00:47:51,490 --> 00:48:01,710
+إنه إذا سويت تجربة هل الموضوع علني ولا سرييعني
+
+524
+00:48:01,710 --> 00:48:06,570
+مثلًا حكينا اللي راح نحكي مثلًا بالاخير الـGenetic
+
+525
+00:48:06,570 --> 00:48:14,160
+Screeningمن قضية برضه فيها Privacy يعني إذا أنا
+
+526
+00:48:14,160 --> 00:48:21,800
+والله عملت Screen وطلع إنسان إيجابي ممكن هناك مثلا
+
+527
+00:48:21,800 --> 00:48:26,940
+ناس بيرغبوش في أن حد يعرف عنهم في مثلا قد تكون نوع
+
+528
+00:48:26,940 --> 00:48:34,060
+من سبب الخجل، سبب التأثير، قلق واحنا مطلوب كدكتور
+
+529
+00:48:34,060 --> 00:48:39,860
+أنه نخفف قلق أي إنسان يعنيفهذا واجب لجميع المرضى
+
+530
+00:48:39,860 --> 00:48:47,980
+ماشي إذا الأمور فيها خطر على صحة المجتمع أو مرض
+
+531
+00:48:47,980 --> 00:48:53,040
+معدي وإذا أنا ما حجرت هذا الإنسان وما عمّمت على
+
+532
+00:48:53,040 --> 00:48:57,660
+إنه هذا مصاب لفترة معينة أنا منع أن أتعامل معه أنا
+
+533
+00:48:57,660 --> 00:49:01,880
+أسس زي الـ COVID هذا مشكلة إذا الواحد يقول كل واحد
+
+534
+00:49:01,880 --> 00:49:06,420
+أنا حقي أنا سريت معلومتي إذا أنا إيجابي إنك ما
+
+535
+00:49:06,420 --> 00:49:11,870
+تبلغوما تخلّي حد يعرف ويظل الواحد يشتم زي ما بده
+
+536
+00:49:11,870 --> 00:49:15,890
+ناشي؟ فالـ Privacy of genetic information أو
+
+537
+00:49:15,890 --> 00:49:19,490
+medical information Misuse of genetic information
+
+538
+00:49:19,490 --> 00:49:26,430
+يعني هذه أهم شيء مثلًا مرات في خيارات مثلًا جوانب
+
+539
+00:49:26,430 --> 00:49:32,870
+زي التأمين مثلًا توظيف كذا يعني احنا في أمريكا
+
+540
+00:49:32,870 --> 00:49:36,210
+المساواة بين العراق من المبادئ اللي عندهم مشكلة
+
+541
+00:49:36,210 --> 00:49:42,380
+فيهاوالله أنا بعلم للتوضيح اللون الإنسان هو شغل
+
+542
+00:49:42,380 --> 00:49:48,920
+واضح وأنا أسير يجيني أبيض أو يجيني أسود ماوضقوش
+
+543
+00:49:48,920 --> 00:49:54,520
+خصوصا إذا كان من الحكومة أو من الأشياء مش المؤسسات
+
+544
+00:49:54,520 --> 00:50:00,050
+الخاصة الخاصة إذا بالذاتيعني زي ما تقول شخصية أنا
+
+545
+00:50:00,050 --> 00:50:08,110
+والله حر والله إنسان يعني أسمر اللون وكذا بعتبره
+
+546
+00:50:08,110 --> 00:50:14,710
+مرعب بعتبره يعني عندي حق يعني هذا مالي وانا صاحب
+
+547
+00:50:14,710 --> 00:50:20,510
+المؤسسة وانا حر، بتكون مؤسسات عامة، بتكون حكومية،
+
+548
+00:50:20,510 --> 00:50:27,770
+بتكون كذا، لأ الأصل تكون النسب متساوييعني عشرة
+
+549
+00:50:27,770 --> 00:50:32,770
+بالمئة من الـ population سود أو فارقة إذا عشرة
+
+550
+00:50:32,770 --> 00:50:36,310
+بالمئة من الشرطة لازم تكون سود عشرة بالمئة
+
+551
+00:50:36,310 --> 00:50:41,250
+بالموظفي الفكومة لازم تكون سود ما بيصير مثلا كلهم
+
+552
+00:50:41,250 --> 00:50:45,310
+يكونوا بيض مايكونش ولا واحد أسود يعني فإيه قضية
+
+553
+00:50:45,310 --> 00:50:50,070
+التأمين، قضية التوظيف، قضية الحقوق والتعامل مع
+
+554
+00:50:50,070 --> 00:50:56,840
+الناس كلها فيها مشاكل أخلاقية ويلهايعني مبادئ
+
+555
+00:50:56,840 --> 00:51:02,560
+أخلاقية يجب أن ينتبه لها الواحدة فيعني هدولة يعني
+
+556
+00:51:02,560 --> 00:51:10,500
+كأمثلة من المناطق الأشياء اللي قد تكون هنا آخر الـ
+
+557
+00:51:10,500 --> 00:51:21,700
+slide حاطينه على إنه قصة إمرأة شو اسمه عمرها الآن
+
+558
+00:51:21,700 --> 00:51:25,930
+أربعين سنةعندها طلع بيّن Autosomal Dominant
+
+559
+00:51:25,930 --> 00:51:30,130
+Disorder يعني اللي حكيناها مثلا زي Alzheimer أسف
+
+560
+00:51:30,130 --> 00:51:34,050
+اللي هو Huntington's Chorea هذا مرض والله سيء
+
+561
+00:51:34,050 --> 00:51:38,990
+وبيقتل الإنسان بالأخير بس بيظهر وبيبدأ على عمره
+
+562
+00:51:38,990 --> 00:51:45,830
+متأخر فصدفة إنه اكتشفنا المرض عند هذه السيدة
+
+563
+00:51:45,830 --> 00:51:51,930
+ولقينا عندها mutation معين عندها بنت من زوجها
+
+564
+00:51:51,930 --> 00:51:57,980
+الأولوالبنت كمان عندها كأنه هاي الـ motivation
+
+565
+00:51:57,980 --> 00:52:06,760
+وعرفت عندها ابن أو أخ غير شقيق من رجل آخر بعد طلاق
+
+566
+00:52:06,760 --> 00:52:11,520
+الزوجين الأولين المرأة هاي اللي عمرها الآن أربعين
+
+567
+00:52:11,520 --> 00:52:18,540
+تزوجت زلمة تانية وجابت منه طفل ولد فالبنت والأم
+
+568
+00:52:19,390 --> 00:52:24,530
+عندهم الـ Genetic Mutation لـ Autosomal Dominant
+
+569
+00:52:24,530 --> 00:52:29,730
+وهي Serious وبتبين على عمر صغير هل واجب أن نبحث
+
+570
+00:52:29,730 --> 00:52:35,170
+أخوهم؟ اللي هو يعني الغير شقيق للأخت للبنت هذه
+
+571
+00:52:35,170 --> 00:52:40,270
+المصابة هل يجب أن نخبره عن هذا الموضوع ولا لأ؟
+
+572
+00:52:40,270 --> 00:52:45,510
+نتركه وما نقولهوش ولا كده؟ يعني إذا الواحد بقرا
+
+573
+00:52:45,510 --> 00:52:54,380
+هذا السيناريو مثالهل يجب أن نبلغه ولا ما نبلغوش؟
+
+574
+00:52:54,380 --> 00:52:59,260
+هو أنا بشرح طريقة تفكير المؤلفين إنه فيه أول شي
+
+575
+00:52:59,260 --> 00:53:09,440
+Clinical Question يعني القرار يعني في الفقه هناك
+
+576
+00:53:09,440 --> 00:53:17,920
+قاعدة تقول الحكم
+
+577
+00:53:17,920 --> 00:53:26,040
+على الشيءفرق ليه الفهم عن هذا الشيء يعني عشان هيك
+
+578
+00:53:26,040 --> 00:53:29,580
+كان فيه كثير من القضايا الطبية بالذات اللي كانت
+
+579
+00:53:29,580 --> 00:53:36,120
+فيها جوانب أخلاقية قانونية كده نجد القضاء وفقهاء
+
+580
+00:53:36,120 --> 00:53:40,840
+الشرق الحنيف بيقولك بيعملوا اجتماعات معنى كطباء
+
+581
+00:53:40,840 --> 00:53:47,600
+عشان يسألونا شو معنى كده شو معنى كده واللهبالذات
+
+582
+00:53:47,600 --> 00:53:51,800
+يعني، يعني بالذات في جوانب الأخلاقية إذا بنتبه
+
+583
+00:53:51,800 --> 00:53:58,220
+الواحد، نقطتين، بداية الحياة ونهاية الحياة، هدولة
+
+584
+00:53:58,220 --> 00:54:03,800
+بتلاقي عليهم جدال أخلاقي كبير، إذا مثلا الهولندا
+
+585
+00:54:03,800 --> 00:54:10,520
+لإنسان طبيعي، مش مكتئب، مش عنده depression، يقولك
+
+586
+00:54:10,520 --> 00:54:15,270
+والله أنا عندي سرطان أو عندي مرض لا يرجع شفاهيا
+
+587
+00:54:15,270 --> 00:54:19,090
+دكتور في عيد ميلادي الجاي اقضي عليّ واعطيني حقني
+
+588
+00:54:19,090 --> 00:54:26,610
+أموت وأكمل وأحرجوا جسمي وخلاص ملّيت من هذا التوتر
+
+589
+00:54:26,610 --> 00:54:32,810
+والقلق وكذا فيه في هولندا هذا بيحصلوا مقبول شرعيا
+
+590
+00:54:32,810 --> 00:54:36,470
+وأخلاقيا
+
+591
+00:54:36,470 --> 00:54:40,290
+ومجتمعيا يعني فيه غالبية أو ناس كبيرة بتقبل هذا
+
+592
+00:54:40,290 --> 00:54:45,200
+الاشياء بتلاقيهم كلهم بتلاقي الليفوالله أنا بعد
+
+593
+00:54:45,200 --> 00:54:51,400
+الشهرين أنا متفق مع الدكتور يخلص عليّ ومدام أنا مش
+
+594
+00:54:51,400 --> 00:54:58,440
+مبتعب وبالقانون وبيصير يعني باعطي الدكتور الحقنة
+
+595
+00:54:58,440 --> 00:55:06,840
+القاتلة والإنسان هذا بيكمل فالسيناريو هذا يعني
+
+596
+00:55:06,840 --> 00:55:15,860
+بيأكد على أولا إنه إحنا يجب علىمن يعني يتعامل مع
+
+597
+00:55:15,860 --> 00:55:21,720
+هذا الجانب ويريد أن يعطي حكمًا أخلاقيًا وانتباه
+
+598
+00:55:21,720 --> 00:55:27,240
+لهذا الجانب أول شيء يجب أن يكون فهما تمامًا جوانب
+
+599
+00:55:27,240 --> 00:55:31,740
+الطبية الصحية العلمية من هذا الحالة قضية
+
+600
+00:55:31,740 --> 00:55:35,220
+Penetrance of the Disorder يعني هل هناك احتمالية
+
+601
+00:55:35,220 --> 00:55:40,020
+أن هذا الفحث صحيح قال إنه في اشتباه يصير هذا
+
+602
+00:55:40,020 --> 00:55:47,140
+الحالةبس هل هي متأكدة؟ مافيش احتمالي إن الفحص هذا
+
+603
+00:55:47,140 --> 00:55:55,480
+مش بالقوة؟ هل هو lethal؟ هل هي كذا؟ طبعاً بيرجع
+
+604
+00:55:55,480 --> 00:55:59,820
+الأمر حسب القانون يعني في دول كتيرة القانون بيقولك
+
+605
+00:55:59,820 --> 00:56:05,460
+الإجهاد حلال ولا تستطيع يعني يعني يعاقب الطبيب
+
+606
+00:56:05,460 --> 00:56:09,860
+النسائي اللي ما بيسوي الإجهاد مثلا السبب إنه
+
+607
+00:56:09,860 --> 00:56:14,380
+بيقولكإذا المرأة هذه إن هي مقررة وهذا جزء من جسمها
+
+608
+00:56:14,380 --> 00:56:18,680
+مقررة بدها تخلص منه إذا أنت ما سويت لها يا طبيب
+
+609
+00:56:18,680 --> 00:56:23,340
+الإجهاض بطريقة سليمة علمياً أو طبياً أو صحياً
+
+610
+00:56:23,340 --> 00:56:28,220
+بتروح تسويها عند إنسان غير متخصص ومافيش نباطي
+
+611
+00:56:28,220 --> 00:56:32,660
+ومافيش كذا وبتتوفى لأنها سوّت الإجهاض بطريقة غير
+
+612
+00:56:32,660 --> 00:56:41,540
+صحية فهناك يعني موازين مختلفة فبالتالي يعنييجب أن
+
+613
+00:56:41,540 --> 00:56:48,820
+يكون هناك أسئلة للألم والطب تبع الحالة والـ
+
+614
+00:56:48,820 --> 00:56:54,780
+Counseling Questions ما هي الأسئلة التي يعني والـ
+
+615
+00:56:54,780 --> 00:57:00,840
+المتضادات من القواعد
+
+616
+00:57:00,840 --> 00:57:05,800
+الأخلاقية وبعدين الـ Legal و الـ Practical Issues
+
+617
+00:57:05,800 --> 00:57:12,310
+كموال جوارب القانونيةوالعملية لهذا الجانب فهذا
+
+618
+00:57:12,310 --> 00:57:19,030
+سيناريو مثال ويعني كما ذكرنا في جميع هذه النقاط إن
+
+619
+00:57:19,030 --> 00:57:24,570
+شاء الله ربنا يوفقنا ويهدينا ونتعلم يعني يصير واحد
+
+620
+00:57:24,570 --> 00:57:29,510
+زي ما بعرف التشريح و ال chemistry و ال
+
+621
+00:57:29,510 --> 00:57:33,590
+biochemistry و ال physiology يصير يعني كمانفي الـ
+
+622
+00:57:33,590 --> 00:57:40,810
+Ethics والمبادئ الأخلاقية والمبادئ القانونية
+
+623
+00:57:40,810 --> 00:57:45,790
+والمبادئ الاجتماعية في الطب كذلك مبارك الله فيكم
+
+624
+00:57:45,790 --> 00:57:52,750
+وبتوقف فيك إذا حد عنده أي سؤال أنا جاهز نقطة أخيرة
+
+625
+00:57:52,750 --> 00:57:57,290
+كأنه إنتبهت إنه حد بيسأل كيف راح يكون امتحان يوم
+
+626
+00:57:57,290 --> 00:58:01,090
+الجمعة برضه راح يكون MCQ زي المرة اللي حدت فسعاد
+
+627
+00:58:01,090 --> 00:58:08,350
+الشباترالأخيرة، نعم في
+
+628
+00:58:08,350 --> 00:58:11,650
+المحاضرة
+
+629
+00:58:11,650 --> 00:58:14,770
+اللي فاتت تقول بدا تريد شرح الـ Validity و الـ
+
+630
+00:58:14,770 --> 00:58:20,690
+Utility أعتقد شرحتهم بسرعة فبعت لك صورة فيها الـ
+
+631
+00:58:20,690 --> 00:58:23,810
+screenshot يعني إذا كنت فاعترضها و تريد شرحها
+
+632
+00:58:23,810 --> 00:58:31,010
+عسرية هاي ال screenshot بالنسبة لمحاضرة اليوم هاي
+
+633
+00:58:31,010 --> 00:58:38,760
+downloadده محاضرة اليوم فيها
+
+634
+00:58:38,760 --> 00:58:45,260
+سلعة محاضرة اليوم؟ لأ، المحاضرة اليوم بسيطة، الحمد
+
+635
+00:58:45,260 --> 00:58:53,660
+لله، وصغيرة أه، طيب، بس فيها مبادئ أساسية صحيح
+
+636
+00:58:53,660 --> 00:59:00,980
+يعني شوف، حط إن عندك يعني ده هيك بنحطها بمثال سريع
+
+637
+00:59:02,280 --> 00:59:08,420
+لما تأخذ أنساء مثلًا أنا ممكن تعمل شريح سكرين لها
+
+638
+00:59:08,420 --> 00:59:12,700
+بس يا دكتور نعم ممكن تعمل شريح سكرين لها بس عشان
+
+639
+00:59:12,700 --> 00:59:17,820
+تحدد فيه نقطة معينة فيها بتاعة التوضيح أشي النقطة
+
+640
+00:59:17,820 --> 00:59:26,980
+اللي بدك إياها أه وإن screen أو photo أه إيش
+
+641
+00:59:26,980 --> 00:59:32,420
+السؤال؟من عند قصة الـPPV والأرقام هذه اللي قدامي
+
+642
+00:59:32,420 --> 00:59:42,000
+اسمع، خدها كفاهم، الآن مثلا، مثلا، ناخد مثال
+
+643
+00:59:42,000 --> 00:59:51,560
+وحقيقة أنا باجي فحص للـHIV، الـHIV له سبب الـAIDS
+
+644
+00:59:51,560 --> 00:59:58,290
+وعندي فحص ممتاز إليه جدا، 99%Sensitive و99%
+
+645
+00:59:58,290 --> 01:00:07,250
+Specific صح؟ نفترض هيك معاي؟
+
+646
+01:00:07,250 --> 01:00:16,970
+أه تمام سيدي فإفرض إنه أنا هذا الفحص هو ممتاز 99%
+
+647
+01:00:16,970 --> 01:00:21,850
+جيت أخدته بالحالة الأولى ك population screening
+
+648
+01:00:21,850 --> 01:00:29,580
+يعني قررتمثلًا في الأردن احتمالية إنسان عنده HIV
+
+649
+01:00:29,580 --> 01:00:34,860
+مثلًا واحد بقدر يعني هيك تقديري واحد بالمائة ألف
+
+650
+01:00:34,860 --> 01:00:40,760
+ماشي يعني هيك يعني احنا تقريبًا من شخص من أول ما
+
+651
+01:00:40,760 --> 01:00:46,620
+بدأ الآن بقدر على مدى سنين كلها أوالي ألف بني آدم
+
+652
+01:00:46,620 --> 01:00:53,940
+تقريبًا فلما تخذها إنه هي شو الاحتمالية وجودهاواحد
+
+653
+01:00:53,940 --> 01:00:59,940
+بالألف وواحد بالـ 100 ألف مثلًا، نفترض هيك ماشي؟
+
+654
+01:00:59,940 --> 01:01:04,620
+ماشي معاه كريم؟
+
+655
+01:01:04,620 --> 01:01:11,980
+فلمّا أجي لهذا الفحص، هنا حاطينه كمثال حقيقي على
+
+656
+01:01:11,980 --> 01:01:19,150
+أرقام الـ APOE هذا عبارة عن فحص للـ Alzheimerبدل
+
+657
+01:01:19,150 --> 01:01:24,330
+الـ HIV اللي هنا بندرس الـ Alzheimer ماشي وبدل فحص
+
+658
+01:01:24,330 --> 01:01:28,310
+الـ Antibody أو شغل معين الـ Antigen بفحص هذا
+
+659
+01:01:28,310 --> 01:01:34,130
+الشيء بس الفكرة أنه الفحص أنا استخدمته لـ
+
+660
+01:01:34,130 --> 01:01:40,330
+Population Screen لحالة بنقصين نادرة فهنا مثلا
+
+661
+01:01:40,330 --> 01:01:45,670
+بالنسبة للـ HIV افرض واحد بالميت ألف لما تيجي تحط
+
+662
+01:01:45,670 --> 01:01:52,810
+الأرقاممقول فحص 99% sensitive 99% specific مافيش
+
+663
+01:01:52,810 --> 01:01:59,110
+عادة فحص بهذه الأرقام يعني 95، 90% ممتاز كتير أنا
+
+664
+01:01:59,110 --> 01:02:09,550
+بقولك خليه 99% شو نتيجة الأمر هذا أنه أنت راح صحيح
+
+665
+01:02:09,550 --> 01:02:18,110
+تقريبًا تصيد كل الناس اللي عندهم الـ HIV99% يعني
+
+666
+01:02:18,110 --> 01:02:26,490
+مثلًا الأردن شو اسمه الأردن 10 ملايين أقريبًا 99%
+
+667
+01:02:26,490 --> 01:02:33,150
+منهم لما نسوي الـ Population Screen راح يكون أو
+
+668
+01:02:33,150 --> 01:02:40,610
+افترضنا إنه الـ HIV واحد بالمائة ألف فالنتيجة كل
+
+669
+01:02:40,610 --> 01:02:49,670
+مليون فيهم عشرةوعندي عشر ملايين، بلاش 100 مليون،
+
+670
+01:02:49,670 --> 01:02:53,790
+واحد بالـ100 ألف خلّي الـHIV واحد بالعشر تلات،
+
+671
+01:02:53,790 --> 01:02:57,590
+نفترض أظن أنه أقرب لواحد بالـ100 ألف، بس افتراضًا
+
+672
+01:02:57,590 --> 01:03:02,190
+نفترض أنه واحد بالمليون، واحد بالعشر تلات فكل
+
+673
+01:03:02,190 --> 01:03:06,010
+مليون فيهم مية، وعشر ملايين يعني بيطلعوا عشر تلات
+
+674
+01:03:06,010 --> 01:03:10,510
+بني أدم أنا راح أصيد العشر تلات بني أدم، العشر
+
+675
+01:03:10,510 --> 01:03:16,340
+تلاتراح يكونوا تسعمية و تسعين تسعمية تسعتلاف و
+
+676
+01:03:16,340 --> 01:03:20,900
+تسعمية و تسعين واحد راح أصيبهم وعشرة مش راح أصيبهم
+
+677
+01:03:20,900 --> 01:03:27,680
+فأنا لقيت تسعمية و تسعتلاف و تسعمية واحد عندهم
+
+678
+01:03:27,680 --> 01:03:32,800
+المرض ستهم، بس شو اللي راح يصير؟ لإن أنا أعمل فحص
+
+679
+01:03:32,800 --> 01:03:39,780
+لكل الناس أنا لازم أفحصل عشر ملايين، العشر ملايين
+
+680
+01:03:40,620 --> 01:03:44,000
+التسعة يعني الغالبية العظمة منهم ما عندهمش تقريبًا
+
+681
+01:03:44,000 --> 01:03:48,500
+عشر ملايين يعني غير العشر تلافة دولة البقية التسع
+
+682
+01:03:48,500 --> 01:03:54,580
+ملايين، التسعمية، وتسعين ألف ماعندهمش المرض فلما
+
+683
+01:03:54,580 --> 01:03:58,940
+يكون الـ specificity برضه تسعة و تسعين بالمية
+
+684
+01:03:58,940 --> 01:04:06,000
+النتيجة إنه واحد بالمية من التسع ملايين راح يطلع
+
+685
+01:04:06,000 --> 01:04:15,140
+حواليتقريبًا بقدر مثلًا 1% من 9، 10 ملايين تقريبًا
+
+686
+01:04:15,140 --> 01:04:24,760
+راح يطلعوا تقريبًا شو اسمه؟ 100 ألف ماشي، 1% من 10
+
+687
+01:04:24,760 --> 01:04:31,760
+ملايين كام بتطلعوا هيك يحفظوه تقريبًا 10
+
+688
+01:04:31,760 --> 01:04:39,010
+ملايينواحد بالمية المية المليون في عشر تلات في
+
+689
+01:04:39,010 --> 01:04:45,630
+عشرة راح يطلع مائة ألف واحد صحيح صح راح يطلع إنه
+
+690
+01:04:45,630 --> 01:04:50,150
+إيجابي من الـ Negative False Positive يعني هو من
+
+691
+01:04:50,150 --> 01:04:52,890
+الـ Negative بالأصلي بس راح يطلع False Positive
+
+692
+01:04:52,890 --> 01:04:58,610
+راح يطلع بحدود أبو مائة ألف واحد فشو النتيجة صفتت؟
+
+693
+01:04:58,610 --> 01:05:03,920
+إنه لما يطلع عندك Test Positiveحقيقةً عشرة بالمية
+
+694
+01:05:03,920 --> 01:05:08,520
+بس من الـ positives هم الـ true positives وتسعين
+
+695
+01:05:08,520 --> 01:05:12,160
+بالمية من ال positives هم كانوا false positives
+
+696
+01:05:12,160 --> 01:05:15,920
+يعني هم negative فأنا في الحالة هذه ما استفدت من
+
+697
+01:05:15,920 --> 01:05:22,880
+الفحص ما بيصير، ما بيصيرش أسويها، ليش؟ لأن الفحص
+
+698
+01:05:22,880 --> 01:05:28,000
+هذا أنا بسويه في مجموعة احتمالية وجود المرض قليل
+
+699
+01:05:28,000 --> 01:05:35,320
+كتير وبالتالي أنابالتالي راح يكون الاستفادة منه مش
+
+700
+01:05:35,320 --> 01:05:42,020
+كتيرة واضح؟ بينما لو جبت هذا الـ Test وروحت مثلا
+
+701
+01:05:42,020 --> 01:05:48,400
+على سجن قلنا السجن فيه ناس تبعين مخدرات فيه ناس
+
+702
+01:05:48,400 --> 01:05:54,560
+بضربوا IV Drug Abuse فيه ناس عندهم سلوكيات أخلاقية
+
+703
+01:05:54,560 --> 01:06:03,520
+جنسية غير سوية مثلا ماشي والـ HIVبنسبته بتوقع أنها
+
+704
+01:06:03,520 --> 01:06:07,480
+أعلى أو أنا ممكن أكون درست وشوفت أنه عندهم نسبة
+
+705
+01:06:07,480 --> 01:06:13,520
+أعلى باستخدام هذا الفحص بيصير في هذه المجموعة كـ
+
+706
+01:06:13,520 --> 01:06:19,920
+Diagnostic Testing اللي .. اللي شو اسمه؟ اللي لما
+
+707
+01:06:19,920 --> 01:06:22,760
+يكون Positive بيكون فعلا Positive لما يكون
+
+708
+01:06:22,760 --> 01:06:27,720
+Negative فعلا بيكون Negative فاهم عليك كده؟ فهنا
+
+709
+01:06:27,720 --> 01:06:31,690
+انت ال testمرة استخدمته كـ Screening للـ
+
+710
+01:06:31,690 --> 01:06:37,810
+population والنتيجة راح تكون أنه أنت يعني ما راح
+
+711
+01:06:37,810 --> 01:06:43,730
+تستفيد فهم عليك كده؟ أما إذا بستخدمه كـ Diagnostic
+
+712
+01:06:43,730 --> 01:06:47,570
+Testing يعني شوف هنا، اقرأ معاه الـ Clinical
+
+713
+01:06:47,570 --> 01:06:53,350
+Validity في الحالة الأولى أنا جيت، شو سويت؟ جبت ال
+
+714
+01:06:53,350 --> 01:06:58,050
+population وكل الـ Asymptomatic Individuals Age 65
+
+715
+01:06:58,050 --> 01:07:04,650
+لـ 74جيت على مجتمع كل البني آدمين اللي من عمره 65
+
+716
+01:07:04,650 --> 01:07:11,430
+لـ 74 جيت وهم ماعندهم مش عارفين جيت فحصتهم أنا
+
+717
+01:07:11,430 --> 01:07:15,090
+بعرف الـ Population Prevalence of this condition
+
+718
+01:07:15,090 --> 01:07:21,410
+اللي هو Alzheimer Disease 3000% شايف عليا؟ اللي
+
+719
+01:07:21,410 --> 01:07:27,010
+لما تشوف الـ Test اللي انت مع أنه كويس هو بالأخير
+
+720
+01:07:27,010 --> 01:07:32,750
+مالوش قيمةالـ Positive Predictive Value لو هذه 6%
+
+721
+01:07:32,750 --> 01:07:38,150
+الـ Positive Predictive Value لـ الـ 23% يعني أنت
+
+722
+01:07:38,150 --> 01:07:43,930
+حتى الـ 23% معناته 77% من اللي راح يطلعوا Positive
+
+723
+01:07:43,930 --> 01:07:50,050
+هم False Positive هم Negative بالأصل ماشي؟
+
+724
+01:07:50,050 --> 01:07:56,030
+والملاحظة الثالثة كمان أنه لهذه الحالة و لهذه
+
+725
+01:07:56,030 --> 01:08:01,600
+المرض مافي إيش تسويهلو في إيش تسويه تقول ماشي بفحص
+
+726
+01:08:01,600 --> 01:08:06,740
+بظل بهمني يعني الـ Phenylketonuria ما هو under من
+
+727
+01:08:06,740 --> 01:08:11,880
+3% أقل من 3% مع ذلك بنسويه لأنه في إيش تسويه بس
+
+728
+01:08:11,880 --> 01:08:18,240
+هنا مافيش يعني intervention أو علاج تقدر تسويه شو
+
+729
+01:08:18,240 --> 01:08:22,220
+راح تسبب؟ أنت راح تعمل psychological stress for
+
+730
+01:08:22,220 --> 01:08:26,700
+most people يعني كتير ناس هيطلع false positive و
+
+731
+01:08:26,700 --> 01:08:30,970
+negativeو False Positive وبالتالي راح تسوي له قلق
+
+732
+01:08:30,970 --> 01:08:37,570
+و اللي مرات عنده الـ Negative طلعت برتاح و ب .. ب
+
+733
+01:08:37,570 --> 01:08:41,030
+.. ب .. يعني ب .. ب .. بفرد جرين و أنا والله طلعت
+
+734
+01:08:41,030 --> 01:08:44,150
+Negative مش راح يصيبني هذا و أنت بتعطيه False
+
+735
+01:08:44,150 --> 01:08:50,530
+Reaction لأنه ممكن يكون غلط وإنما لو أنا جيت مثال
+
+736
+01:08:50,530 --> 01:08:57,770
+آخر أخدت اللي عمارهمبرضه 65 ل 74 بس عنده معراضة ال
+
+737
+01:08:57,770 --> 01:09:02,630
+dimension هدولة مجموعة ناس أجوا اشتكوا والله أنا
+
+738
+01:09:02,630 --> 01:09:06,390
+بنسأت والله أنا بحط ال issue و بعدين بنسأت وين
+
+739
+01:09:06,390 --> 01:09:11,590
+حطيته طلعت على السوق و بعدين ماعرفتش أرجع بيتي
+
+740
+01:09:11,590 --> 01:09:16,730
+والله أنا كذا يعني ناس عندهم مشاكلة ماشي واضح يا
+
+741
+01:09:16,730 --> 01:09:17,190
+كريم؟
+
+742
+01:09:19,940 --> 01:09:23,880
+- يا عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا
+
+743
+01:09:23,880 --> 01:09:24,100
+عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا
+
+744
+01:09:24,100 --> 01:09:27,360
+عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا
+
+745
+01:09:27,360 --> 01:09:31,180
+عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا
+
+746
+01:09:31,180 --> 01:09:35,400
+عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا
+
+747
+01:09:35,400 --> 01:09:41,640
+عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا
+
+748
+01:09:41,640 --> 01:09:49,930
+عزيزي، يا عزيزي، يا عزيزيتطلع عندهم ثلاث حقيقيين
+
+749
+01:09:49,930 --> 01:09:54,210
+واحد بس الكذب أو إذا الـ Combination التانية أنت
+
+750
+01:09:54,210 --> 01:10:00,950
+بتوصل 98% يعني من خمسين بني آدم تسعة و أربعين
+
+751
+01:10:00,950 --> 01:10:06,990
+بيكونوا حقيقيين فالفائدة تبع الـ Test بهذه الطريقة
+
+752
+01:10:06,990 --> 01:10:13,310
+بتكون الفائدة لهذه الـ Test في الطريقة إيش إنه لو
+
+753
+01:10:13,310 --> 01:10:21,910
+كان إنسان عندهالـ… عنده dementia حقيقية وبداية
+
+754
+01:10:21,910 --> 01:10:27,110
+عراض والـ Test طالع Negative فاروح بدور على إشي
+
+755
+01:10:27,110 --> 01:10:30,490
+ثاني هذا مش الـ Alzheimer اللي أنا ماقدرش أتويله
+
+756
+01:10:30,490 --> 01:10:35,630
+إشي لأ هذا مثلا عنده الغد الدراقية مضروبة والله
+
+757
+01:10:35,630 --> 01:10:42,390
+عنده نقص تروية من شرايين الدماغ عنده سبب آخر للـ
+
+758
+01:10:42,390 --> 01:10:47,190
+dementia فبالتاليلما نكون الحالي بهذه الطريقة
+
+759
+01:10:47,190 --> 01:10:52,870
+بيصير عندي Suspicion that other potentially
+
+760
+01:10:52,870 --> 01:10:57,150
+treatable cause بيكون، لو عنده Hypothyroidism
+
+761
+01:10:57,150 --> 01:11:00,750
+بيعطيه Thyroxine بيحسنه، بتروح، بيصير كويس، بتروح
+
+762
+01:11:00,750 --> 01:11:06,050
+هاي الشغل منه، واحد عنده مرض نفسي، اكتئاب، كذا،
+
+763
+01:11:06,050 --> 01:11:09,960
+بيعطيه دوة، بتحسن، بتروحفانت هنا بتصير تدور على
+
+764
+01:11:09,960 --> 01:11:14,120
+إشي ثاني لأنك إذا قلت إنه high Alzheimer خلاص،
+
+765
+01:11:14,120 --> 01:11:17,600
+مابتقدرش تسوي له إشي و produces unnecessary
+
+766
+01:11:17,600 --> 01:11:25,700
+testing فهذه الأهمية إنه الفحص ولو إن اتنينهم 99%
+
+767
+01:11:25,700 --> 01:11:32,200
+sensitive و specific، شوه أهمية وين تبقى بسويها؟
+
+768
+01:11:32,200 --> 01:11:35,400
+ففيه Clinical Validity و Clinical Utility يعني
+
+769
+01:11:36,300 --> 01:11:40,700
+استفادة ومن وين هو valid يعني الـ «تست» هذا للـ
+
+770
+01:11:40,700 --> 01:11:44,220
+population screening غلط، ما بيصير استويت، مش يقول
+
+771
+01:11:44,220 --> 01:11:47,140
+أنا عندها الـ «تست» يلّا كل واحد عنده، خلاص بعمله
+
+772
+01:11:47,140 --> 01:11:51,860
+يا وصير أخبص، فاهم عليك؟ إن شاء الله أنه يكون حق
+
+773
+01:11:51,860 --> 01:11:55,440
+–طبعا، يعني القصد إنه الـ «symptoms» أو الـ
+
+774
+01:11:55,440 --> 01:11:57,360
+«diagnosis» ممكن يعمل «reduce» للـ «general
+
+775
+01:11:57,360 --> 01:12:01,780
+population» ويسهلك المنطق الفوصات؟ –لأ، بدك تقول
+
+776
+01:12:01,780 --> 01:12:09,070
+إنه، بدك تقول if not، هذا الـ«test»بهاي النسب لاجب
+
+777
+01:12:09,070 --> 01:12:13,650
+عمله عند وجود الأعراض إذا مافيش أعراض بصيرش أسوي
+
+778
+01:12:13,650 --> 01:12:20,690
+ماشي يعني مش واحد لأنه قلقام هيك والله أنا خايف
+
+779
+01:12:20,690 --> 01:12:24,690
+عند الـ Alzheimer ولا ماعنديش تعالي أعمل هذا ال
+
+780
+01:12:24,690 --> 01:12:29,170
+test موجود عندنا خليني نعمله لأ إذا ماعندكش المرض
+
+781
+01:12:29,170 --> 01:12:33,780
+من قبل راح تدخل حالك في دوامةوتصير تعمل فعصات
+
+782
+01:12:33,780 --> 01:12:37,260
+وتقلق من أشياء و هو بالأخير بيطلع غلط أما لو في
+
+783
+01:12:37,260 --> 01:12:41,600
+أعراف أه لازم تعملها بكتير إله قيمة أكبر وإله
+
+784
+01:12:41,600 --> 01:12:47,320
+أهمية وإله validity يعني valid يعني سليم أو مظبوط
+
+785
+01:12:47,320 --> 01:12:50,060
+أنك تعمله هيك أو صحيح أنك تعمله
+
+786
+01:12:52,600 --> 01:12:54,140
+- تمام، كنت أتكلم على هذا الأمر في الأخترار.
+-تقول
+
+787
+01:12:54,140 --> 01:12:56,920
+على إنك كنت تحصل على هذا، ولا كنت يعني، بس أتأمل
+
+788
+01:12:56,920 --> 01:13:03,080
+إنه واضح يعني، هي الفكرة إنه من ال .. إذا لو أنت
+
+789
+01:13:03,080 --> 01:13:08,440
+فاهمان الـPrevalence تبع الـDisease بالـPopulation
+
+790
+01:13:08,440 --> 01:13:14,140
+دوره في الـSensitivity والـSpecificity إذا بسوي
+
+791
+01:13:14,140 --> 01:13:18,260
+أنا Screening، بدي إياه Sensitive، أنا إذا بسوي
+
+792
+01:13:18,260 --> 01:13:24,160
+إشي Screening،بدي يا عشان أصيب كل الناس اللي عندهم
+
+793
+01:13:24,160 --> 01:13:28,520
+المرض هذا بيهمني فيه بس ممكن في الحالة هذه راح
+
+794
+01:13:28,520 --> 01:13:32,920
+أصيب ناس ماعندهم مش المرض فبدي بعدها أسوي specific
+
+795
+01:13:32,920 --> 01:13:37,500
+test اللي هو إنه بتأكد إنه ماعندوش مرض، ماعندوش
+
+796
+01:13:37,500 --> 01:13:41,100
+المرض يعني بدك تسويها بالـ two steps في هذا
+
+797
+01:13:41,100 --> 01:13:46,480
+الطريق، أه ماشي؟ يا طيب يا عزيزي يا دكتور الله
+
+798
+01:13:46,480 --> 01:13:51,840
+يحييكفي إذا في أي أسئلة ثانية إن شاء الله خير أنا
+
+799
+01:13:51,840 --> 01:13:56,580
+بظن الإمتحان راح يكون MCQ نفس الـ quiz الأولان
+
+800
+01:13:56,580 --> 01:14:01,620
+ونفس ال midterm بنفس الطريقة الله يوفقكم وشدحانكم
+
+801
+01:14:01,620 --> 01:14:05,900
+نراكم على خير دكتور يعني يعني إمتحان يوم الجمعة إن
+
+802
+01:14:05,900 --> 01:14:11,220
+شاء الله هيكون فيه أسئلة U word دي ليش؟ ولا بس
+
+803
+01:14:11,220 --> 01:14:16,600
+أسئلة MCQ قصيرة انت شو مشكلتك؟ادرس الفنتين، آه
+
+804
+01:14:16,600 --> 01:14:21,780
+يمكن تطلع هون، يمكن تطلع هون، ماشي، تضاركوا تفو
+
+805
+01:14:21,780 --> 01:14:24,420
+الدورة على .. حاضر يا دكتور، حاضر، ماشي، الله
+
+806
+01:14:24,420 --> 01:14:29,520
+يوفركم يعطيك العفو يا دكتور، مع السلامة، مع
+
+807
+01:14:29,520 --> 01:14:34,700
+السلامة، يالا نشوفكم على خير، بكرا المساء بودي لك
+
+808
+01:14:34,700 --> 01:14:38,520
+الأسئلة يا دكتور، يعطيك العفو يا دكتور، سلام عليكم
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/J6cZgtP3lRU.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/J6cZgtP3lRU.srt
new file mode 100644
index 0000000000000000000000000000000000000000..cfbd82d8d7e8a0edd81b91fc8b71e38e04dcd082
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/J6cZgtP3lRU.srt
@@ -0,0 +1,3231 @@
+
+1
+00:00:00,000 --> 00:00:08,060
+أربعة so far طيب احنا المحاضرة بتتسجل وإن شاء
+
+2
+00:00:08,060 --> 00:00:13,520
+الله يعني بالنسبة
+
+3
+00:00:13,520 --> 00:00:21,540
+لكم نبدأ وبالنسبة لزي ما حكينا كل مرة أول شيء ده
+
+4
+00:00:21,540 --> 00:00:28,220
+حد عنده أي أسئلة يعني مراجعات كيف صلّح الكمبيوتر
+
+5
+00:00:28,220 --> 00:00:31,440
+وإن أنا غلطت وإن كان قصدي هيك أو مش قصدي هيك، فما
+
+6
+00:00:31,440 --> 00:00:38,880
+تتراجعي، فبتجننوك الطلاب وبرضوش وبتضيع الوقت احنا
+
+7
+00:00:38,880 --> 00:00:44,000
+المهم أن الواحد يستفيد ويكون يعني حتى بالنسبة
+
+8
+00:00:44,000 --> 00:00:49,220
+للسؤال فاهم ليش هي صح ليش هي غلط المهم الفهم، بغض
+
+9
+00:00:49,220 --> 00:00:53,200
+النظر عن العلامة يعني العلامة مش مهم كتير، الله
+
+10
+00:00:53,200 --> 00:01:01,100
+أعين في أسئلة يا دكتور أحمد؟ لأ، بخصوص المادة لا
+
+11
+00:01:01,100 --> 00:01:09,000
+لسه طيب إن شاء الله اليوم راح نتكلم عن موضوع
+
+12
+00:01:09,000 --> 00:01:14,200
+السرطانات أو الـ Cancer Genetics  و Genomics بصراحة
+
+13
+00:01:14,200 --> 00:01:21,140
+يعني فيه ثلاث سلايدات مهمات جداً عشان يعني تبين
+
+14
+00:01:21,140 --> 00:01:22,720
+مفاهيم معينة
+
+15
+00:01:27,780 --> 00:01:33,160
+والدراسة أو يعني محاولة الدراسة هتكون على نوعين
+
+16
+00:01:33,160 --> 00:01:37,360
+اللي هم الـ Genetics والـ Genomics يعني لنشوف شو
+
+17
+00:01:37,360 --> 00:01:41,900
+دور هاي وهاي وكيف نشتغل فيها وشو اللي بيكون موجود
+
+18
+00:01:41,900 --> 00:01:50,100
+الـ Cancer اللي هي الأورام أو الورم يعني is a big
+
+19
+00:01:50,100 --> 00:01:56,280
+concept مفهوم كبير في الطب حالات كثيرة ومن أهم
+
+20
+00:01:56,280 --> 00:02:03,120
+الأمراض اللي بتسبب وفيات ومن أهم الأمراض اللي يعني
+
+21
+00:02:03,120 --> 00:02:09,880
+بتتم دراستها وفي صعوبة في معالجتها والميزة
+
+22
+00:02:09,880 --> 00:02:16,100
+الأساسية فيها أن التسبب فيها معقد جداً وإن المناعة
+
+23
+00:02:16,100 --> 00:02:19,720
+اللي أنا من نفس خلايا الجسم ما بتقدر تقاومها يعني
+
+24
+00:02:19,720 --> 00:02:23,560
+it is highly complex in etiology الـ etiology
+
+25
+00:02:23,560 --> 00:02:29,160
+تبعها تسبب فيها عادة multifactorial with so many
+
+26
+00:02:29,160 --> 00:02:34,420
+other components وأكثر من خلل معين بيصير بس واضح
+
+27
+00:02:34,420 --> 00:02:38,060
+أن الجينات والوراثة اللي دخل فيها والمناعة اللي
+
+28
+00:02:38,060 --> 00:02:47,050
+دخل فيها وفيه يعني مفاهيم كثيرة الورم هي يعني اللي
+
+29
+00:02:47,050 --> 00:02:50,910
+هي الـ Abnormal cells is like a mass يعني بالأخير
+
+30
+00:02:50,910 --> 00:02:56,590
+ورم يعني كتلة هيكي فحتى تصير كتلة يعني الواحد لازم
+
+31
+00:02:56,590 --> 00:03:01,730
+يتذكر إنه راح يكون في الغالب نمو غير طبيعي يعني
+
+32
+00:03:01,730 --> 00:03:09,020
+خلايا تتكاثر بشكل غير طبيعي زيادة عن اللزوم فهذا قد
+
+33
+00:03:09,020 --> 00:03:13,700
+يكون إيتيولوجيا ويكون سبب بس كمان في أحياناً بتكون
+
+34
+00:03:13,700 --> 00:03:18,160
+أن الخلايا بتموتش بالشكل السريع يعني زي ما ممكن
+
+35
+00:03:18,160 --> 00:03:22,700
+تكون increased cell division as a cause of the
+
+36
+00:03:22,700 --> 00:03:31,180
+tumor formation ممكن decreased apoptosis بالعكس من
+
+37
+00:03:31,180 --> 00:03:35,600
+الجهة التانية بيكون أحياناً هو السبب يعني بس
+
+38
+00:03:35,600 --> 00:03:41,880
+بالأخير يعني بنعتبر abnormal cell cycle الـ
+
+39
+00:03:41,880 --> 00:03:47,680
+cancers اللي هم two other major behavior problems
+
+40
+00:03:47,680 --> 00:03:56,560
+الخلايا الطبيعية لما تشوف خلية مش شابهة لها يعني
+
+41
+00:03:56,560 --> 00:03:59,960
+لو جبت بتري دش وحطيت شوية خلايا
+
+42
+00:04:11,660 --> 00:04:17,440
+الخلايا اللي من نفس النوع لما تنتصل جنب بعض بتوقف
+
+43
+00:04:17,440 --> 00:04:21,140
+والـ cell membrane تبعها بيبطل يتحرك وهذا بيسموه
+
+44
+00:04:21,140 --> 00:04:25,140
+contact inhibition فالـ cancer cells they don't
+
+45
+00:04:25,140 --> 00:04:32,470
+have contact inhibition they keep moving يعني
+
+46
+00:04:32,470 --> 00:04:38,490
+الوصول إلى موقع مستقبل المعانات يعني كثير من
+
+47
+00:04:38,490 --> 00:04:42,810
+الخلايا الثانية اللي بتكون محترمة هيك و بس تصل
+
+48
+00:04:42,810 --> 00:04:46,030
+مكان معين بتوقف عنده، ما عدا الخلايا السرطانية
+
+49
+00:04:46,030 --> 00:04:50,110
+الخلايا السرطانية، هم يفقدون الإنهيبيشن تبعهم بالتواصل
+
+50
+00:04:50,110 --> 00:04:56,350
+وهم لديهم تندنسية لـ Metastasis لـ Metastasize نتيجة
+
+51
+00:04:56,350 --> 00:05:01,320
+الانتشار هذا، بتلاقيها بتروح لأماكن بعيدة فالـ
+
+52
+00:05:01,320 --> 00:05:06,320
+«سلايد» الأول اللي حاطيه لكم إياه بيبين فيها كيف
+
+53
+00:05:06,320 --> 00:05:11,660
+مراحل النشوء
+
+54
+00:05:11,660 --> 00:05:16,540
+وحدوث مشكلة السرطان طبعاً المشكلة حتى لو ظهرت في
+
+55
+00:05:16,540 --> 00:05:20,860
+لحظة معينة عند إنسان بتكون صالة زمان وهي ماشية
+
+56
+00:05:20,860 --> 00:05:27,220
+وبتتكون وبتمر بـ stages كثيرة قبل حتى ما نشوفها هذه
+
+57
+00:05:27,220 --> 00:05:30,900
+مثلاً الـ Normal Epithelium سواء بالـ GI Tract أو
+
+58
+00:05:30,900 --> 00:05:36,900
+في أي محل نجد أن هناك الـ Normal Epithelium اللي
+
+59
+00:05:36,900 --> 00:05:41,160
+موجود والـ Sub-epithelial areas اللي من الـ
+
+60
+00:05:41,160 --> 00:05:45,120
+Appropriate ويكون مثلاً فيه Lymphatic vessels
+
+61
+00:05:45,120 --> 00:05:50,300
+و Blood vessels والأشياء عادية هنا المشكلة الحرارية
+
+62
+00:05:50,300 --> 00:05:55,760
+تبدأ بـ Excessive proliferation of abnormal cells
+
+63
+00:05:55,760 --> 00:06:00,940
+بيبدأ في المنطقة الميكوزالية وبتكون في الـ Stage
+
+64
+00:06:00,940 --> 00:06:06,480
+الأولى بهذا الشكل لأنهم فقدوا انهياب الاتصال
+
+65
+00:06:06,480 --> 00:06:15,410
+وبدأوا بالـ Metastasize تتخرج من
+
+66
+00:06:15,410 --> 00:06:19,770
+محيطها، تتخرج من مكانها، تتدخل إلى الـ sub-mucosal
+
+67
+00:06:19,770 --> 00:06:23,350
+area يعني احنا كثير مثلاً في أشياء في الجلد أو في
+
+68
+00:06:23,350 --> 00:06:27,650
+الـ GI tract لوين خازقة ولوين واصلة، هذا شيء مهم
+
+69
+00:06:27,650 --> 00:06:31,830
+للـ stage وشو اللي نحتاج نعمله للـ treatment
+
+70
+00:06:31,830 --> 00:06:36,590
+والـ management ولكذا فتبدأ بتخرق بالـ Surrounding
+
+71
+00:06:36,590 --> 00:06:41,200
+Tissues، وبعدين They Extend Into Local الـ lymph
+
+72
+00:06:41,200 --> 00:06:46,700
+nodes وبعدين بيصير إذا بينتشر بالدم بيصير يقدر
+
+73
+00:06:46,700 --> 00:06:49,760
+يروح على distant metastases مثل الـ liver، الـ
+
+74
+00:06:49,760 --> 00:06:53,360
+kidneys، الـ lungs يعني الـ lungs number one لأن
+
+75
+00:06:53,360 --> 00:06:57,640
+كل الـ circulation بالأخير لازم تمر بالـ lungs at
+
+76
+00:06:57,640 --> 00:07:01,880
+some stage to oxygenate the hemoglobin فالـ lung
+
+77
+00:07:01,880 --> 00:07:05,940
+metastases، الـ liver، but any other organ they
+
+78
+00:07:05,940 --> 00:07:12,390
+can have metastases هذه مرحلة عادية
+
+79
+00:07:12,390 --> 00:07:15,430
+في
+
+80
+00:07:15,430 --> 00:07:22,490
+الـ «تيومر»
+
+81
+00:07:22,490 --> 00:07:27,810
+أو الـ «كانسيروم» أو الـ «تيولوجيا» أو الـ
+
+82
+00:07:27,810 --> 00:07:33,350
+«جينيسيا» أو الـ «تيومر» الـ Stage الأولى يعني مرات
+
+83
+00:07:33,350 --> 00:07:39,730
+ممكن يسموها «Carcinoma in Situ» يعني لسه محصورة
+
+84
+00:07:39,730 --> 00:07:46,590
+ومش منتشرة وبعدين «Local Invasion» وبعدين «Frank
+
+85
+00:07:46,590 --> 00:07:50,250
+Invasion» و«Reaching the Regional Lymph Nodes»
+
+86
+00:07:50,250 --> 00:07:53,870
+وبعدين بيصير «Distant Metastasis» وهنا بيكون
+
+87
+00:07:53,870 --> 00:07:59,710
+الأمور يعني تقريباً في الغالب انتهت يعني الحالة
+
+88
+00:07:59,710 --> 00:08:10,390
+متقدمة والوضع سيء لما نأتي نشوف هذا الموضوع الآن
+
+89
+00:08:10,390 --> 00:08:13,290
+ستكون عملية عملية عملية عملية عملية عملية عملية
+
+90
+00:08:13,290 --> 00:08:14,050
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+91
+00:08:14,050 --> 00:08:17,450
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+92
+00:08:17,450 --> 00:08:17,470
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+93
+00:08:17,470 --> 00:08:17,730
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+94
+00:08:17,730 --> 00:08:19,150
+عملية
+
+95
+00:08:29,880 --> 00:08:40,360
+في النهاية، يعني فيه table أو فيه paragraph في box
+
+96
+00:08:40,360 --> 00:08:51,100
+حاطين فيه الـ biggest points بالنسبة
+
+97
+00:08:51,100 --> 00:08:58,920
+للـ cancer، their behavior is different سيل سايكلهم
+
+98
+00:08:58,920 --> 00:09:06,820
+مختلفة إنهم يكتشفوا بروتينات جديدة ما نسميه مرات
+
+99
+00:09:06,820 --> 00:09:12,900
+تمور أنتيجين بيكونوا بروتينات جديدة أو شيء مختلف
+
+100
+00:09:12,900 --> 00:09:21,380
+فالـ tumor أو الـ driver genes
+
+101
+00:09:25,240 --> 00:09:29,640
+يعني وين الواحد إذا بده يروح يدور أو شو هي أنواع
+
+102
+00:09:29,640 --> 00:09:34,280
+الجينات اللي بتكون mutated in cancer بالأخير واحد
+
+103
+00:09:34,280 --> 00:09:41,360
+أنه it's mainly really about cell
+
+104
+00:09:41,360 --> 00:09:43,160
+cycle regulation
+
+105
+00:09:45,670 --> 00:09:48,310
+الـ….الـ….الـ…… الـ…… الـ…… الـ…… الـ…… الـ……
+
+106
+00:09:48,310 --> 00:09:48,730
+الـ…… الـ…… الـ…… الـ…… الـ…… الـ…… الـ…… الـ……
+
+107
+00:09:48,730 --> 00:09:49,370
+الـ…… الـ…… الـ…… الـ…… الـ…… الـ…… الـ…… الـ……
+
+108
+00:09:49,370 --> 00:09:54,030
+الـ…… الـ…… الـ…… الـ…… الـ…… الـ…… الـ…… الـ……
+
+109
+00:09:54,030 --> 00:10:06,730
+الـ…… الـ…… الـ…… الـ…… الـ……
+
+110
+00:10:06,730 --> 00:10:09,310
+الـ…
+
+111
+00:10:11,820 --> 00:10:19,880
+الخلية تبدأ تدخل الـ Cell Cycle
+
+112
+00:10:19,880 --> 00:10:23,280
+أو الـ Apoptosis تبدأ تدخل الـ Cell Cycle أو الـ
+
+113
+00:10:27,210 --> 00:10:34,010
+الـ G1 والـ G2 والـ S-Phase والـ M والكذا كلهم بيكونوا
+
+114
+00:10:34,010 --> 00:10:37,990
+بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا
+
+115
+00:10:37,990 --> 00:10:38,850
+بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا
+
+116
+00:10:38,850 --> 00:10:38,930
+بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا
+
+117
+00:10:38,930 --> 00:10:38,990
+بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا
+
+118
+00:10:38,990 --> 00:10:39,050
+بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا
+
+119
+00:10:39,050 --> 00:10:56,470
+بيكونوا بي
+
+120
+00:11:02,000 --> 00:11:06,260
+بالنسبة للـ Cell Cycle وفيه Cell Proliferation
+
+121
+00:11:07,560 --> 00:11:12,500
+لانقسام الخلايا أو تكاثر الخلايا فيه لـ Signal معين
+
+122
+00:11:12,500 --> 00:11:17,600
+إذا صار فيها mutation هنا ويكون فيها نوع من
+
+123
+00:11:17,600 --> 00:11:21,600
+الـ Specific effect on cellular proliferation فإذا
+
+124
+00:11:21,600 --> 00:11:26,880
+فيه Transcription factors شيء بيخلي certain gene
+
+125
+00:11:26,880 --> 00:11:33,220
+become transcribed ممكن الـ Receptors for الـ
+
+126
+00:11:33,220 --> 00:11:36,900
+Transcription Factors اللي هم الـ Main Group هم
+
+127
+00:11:36,900 --> 00:11:40,160
+الـ Tyrosine Kinases الـ Tyrosine هو الـ Amino
+
+128
+00:11:40,160 --> 00:11:43,880
+Acid والـ Kinase هو اللي بيحط الفسفات على الـ
+
+129
+00:11:43,880 --> 00:11:48,440
+Tyrosine أو بيقعوا بيشيلوا منها الفوسفات مرات أخرى
+
+130
+00:11:48,440 --> 00:11:55,680
+فـ Tyrosine kinase هم مجموعات من إنزيمات إتصالية
+
+131
+00:11:55,680 --> 00:12:05,240
+لعديد من الهرمونات أو إشارات من خارج الجسم لتصل
+
+132
+00:12:05,240 --> 00:12:08,410
+إلى الـ Nucleus ويسبب فيه التأثير فيه الـ Growth
+
+133
+00:12:08,410 --> 00:12:12,030
+Factors، الـ Changes أو الـ Mutations الـ
+
+134
+00:12:12,030 --> 00:12:15,190
+Intracellular Other Type of كيناز اللي هم الـ
+
+135
+00:12:15,190 --> 00:12:18,590
+Serine، الـ Threonine اللي هم أنواع من الـ
+
+136
+00:12:18,590 --> 00:12:25,270
+Amino Acids كينازيز الـ PI-3 كينازيز اللي هم الـ
+
+137
+00:12:25,270 --> 00:12:33,470
+Phosphatidyl-Inositol-3 كيناز يعني احنا في المناعة
+
+138
+00:12:34,130 --> 00:12:39,390
+في إذا بتنتبهوا أو انتبهتوا عليه فيه إيش اسمه في
+
+139
+00:12:39,390 --> 00:12:43,110
+الـ Signal Transduction Topic فيه إيش بيسموه
+
+140
+00:12:43,110 --> 00:12:48,550
+الـ Jack والستات الـ Jack اللي هو يعني إله اسم
+
+141
+00:12:48,550 --> 00:12:54,390
+«Just another Kinase» إله اسم غريب بس بالنسبة
+
+142
+00:12:54,390 --> 00:12:57,910
+ل… يعني أستاذ إلي كان يقول لي «Just another
+
+143
+00:12:57,910 --> 00:13:04,140
+kinase» ففي عندنا أنواع كثيرة من الـ Molecules التي
+
+144
+00:13:04,140 --> 00:13:06,280
+تعمل على عملية عبارة عن عبارة عن عبارة عن عبارة عن
+
+145
+00:13:06,280 --> 00:13:08,840
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+146
+00:13:08,840 --> 00:13:09,980
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+147
+00:13:09,980 --> 00:13:13,680
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+148
+00:13:13,680 --> 00:13:15,920
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+149
+00:13:15,920 --> 00:13:16,700
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+150
+00:13:16,700 --> 00:13:17,480
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+151
+00:13:17,480 --> 00:13:24,520
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+152
+00:13:24,520 --> 00:13:29,510
+عن فيه كمان الـ G-Proteins والـ «G-Protein Coupled
+
+153
+00:13:29,510 --> 00:13:32,290
+Receptors» كمان هدولة اللي مدخل بالـ Signal
+
+154
+00:13:32,290 --> 00:13:38,710
+Transduction فيه هنا «mammalian target of
+
+155
+00:13:38,710 --> 00:13:46,090
+rapamycin» هدولة الـ Signal Pathway كمان «Wnt»
+
+156
+00:13:46,090 --> 00:13:50,510
+«β» «Beta» «Catenin signaling transcription
+
+157
+00:13:50,510 --> 00:13:57,760
+factors» حاطينهم مكررينها مرتين، هذا خطأ إملائي أو
+
+158
+00:13:57,760 --> 00:14:01,700
+عدم انتباه من اللي حاطط، بس إن هناك أمثلة كثيرة
+
+159
+00:14:01,700 --> 00:14:07,080
+Differentiation and Lineage Survival حكينا احنا
+
+160
+00:14:07,080 --> 00:14:11,280
+هذولة يمكن الـ Jack والـ Stat وهذولة مشتركات من
+
+161
+00:14:11,280 --> 00:14:16,060
+أكثر من نوع من الخلايا بس لازم يكون لكل نوع خلية
+
+162
+00:14:16,060 --> 00:14:21,040
+فيه specific transcription factor أو regulator for
+
+163
+00:14:21,040 --> 00:14:27,480
+each type of cell وفيه regulators of apoptosis الـ
+
+164
+00:14:27,480 --> 00:14:32,280
+other group of genes اللي هم global effects on the
+
+165
+00:14:32,280 --> 00:14:40,170
+genome and DNA integrity أو Gene Expression المطلوب
+
+166
+00:14:40,170 --> 00:14:45,490
+أن الـ Genome Integrity اللي فيه DNA Repair
+
+167
+00:14:45,490 --> 00:14:48,550
+الـ Chromosomal
+
+168
+00:14:48,550 --> 00:14:51,670
+Segregation الـ Genome and Gene Mutation Inhibition
+
+169
+00:14:51,670 --> 00:14:56,650
+يعني الـ Regulation الـ Gene Expression with
+
+170
+00:14:56,650 --> 00:15:01,950
+Abnormal Metabolizing Effect يعني التأثيرات على
+
+171
+00:15:01,950 --> 00:15:06,630
+الـ Gene Expression اللي فيه Certain Epigenetic
+
+172
+00:15:06,630 --> 00:15:11,560
+Mutations فنتكلم عنهم بما فيه الـ «DNA Methylation»
+
+173
+00:15:11,560 --> 00:15:16,460
+أو «Hydroxymethylation» و«Histone Methylation»
+
+174
+00:15:16,460 --> 00:15:20,480
+أو «Demethylation» أو «Acetylation» «Nucleosome
+
+175
+00:15:20,480 --> 00:15:26,360
+Remodeling» «Chromatin Accessibility»
+
+176
+00:15:26,360 --> 00:15:30,360
+يعني سهولة الوصول لقطع معينة و«Compaction» لما
+
+177
+00:15:30,360 --> 00:15:34,120
+ينضغط وبالتالي ما يقدرش أي شيء يقرأ منها
+
+178
+00:15:34,120 --> 00:15:37,820
+الـ Different levels of gene expression with
+
+179
+00:15:37,820 --> 00:15:41,980
+certain post-transcriptional alterations زي
+
+180
+00:15:41,980 --> 00:15:47,580
+التأثيرات على الـ mRNA والـ Micro-RNAs
+
+181
+00:15:47,580 --> 00:15:53,080
+وهذولة يعتبروا كمان من الـ Epigenetic Control واللي
+
+182
+00:15:53,080 --> 00:15:56,300
+على
+
+223
+00:19:27,100 --> 00:19:33,480
+فيها الجين المطلوب يتم تغييره بشكل بحيث أنه الـ
+
+224
+00:19:33,480 --> 00:19:37,600
+Chromatin والـ DNA يكون accessible للـ RNA
+
+225
+00:19:37,600 --> 00:19:41,640
+بوليماريز اللي راح من الـ DNA يعني يعمل عملية الـ
+
+226
+00:19:41,640 --> 00:19:46,520
+Transcription للـ DNA ويعطيني الـ Gene Expression
+
+227
+00:19:46,520 --> 00:19:51,660
+اللي هو الـ Messenger RNA وبعدين الـ Messenger RNA
+
+228
+00:19:51,660 --> 00:19:57,500
+طبعاً بالأول RNA عادي كامل أو أولي، وبعدين بتصير
+
+229
+00:19:57,500 --> 00:20:05,940
+Splicing وبتكون الـ Messenger RNA المطلوب حتى يصير
+
+230
+00:20:05,940 --> 00:20:11,740
+الـ Gene Protein Expression فهذه هنا، بيصير عندي
+
+231
+00:20:11,740 --> 00:20:15,760
+Variation أنه الـ Copy Number وبكلها بتأثر على الـ
+
+232
+00:20:15,760 --> 00:20:24,360
+Translation و Transcription وبعدين Translation بعد
+
+233
+00:20:24,360 --> 00:20:30,660
+هيك الخلايا هذه بحاجة أن تصير أنها لها Cell Cycle
+
+234
+00:20:30,660 --> 00:20:35,560
+Control وControlled Proliferation يعني إشي قريب من
+
+235
+00:20:35,560 --> 00:20:39,380
+هذا الموضوع يعني الـ Cell Cycle Control يعني اللي
+
+236
+00:20:39,380 --> 00:20:43,660
+هي الـ Checkpoints البروتينز عبارة عن Signal
+
+237
+00:20:43,660 --> 00:20:49,180
+وجزيئات داخل الخلية إذا تنشطت بتطلب من الخلية
+
+238
+00:20:49,180 --> 00:20:52,740
+تسوّي الشي المطلوب اللي هو تنقسم في عندي Growth
+
+239
+00:20:52,740 --> 00:20:56,640
+Factors ودولة راح يكونوا الـ Stimuli from the
+
+240
+00:20:56,640 --> 00:21:00,480
+outside الـ Growth Factors ودولة specific لكل نوع
+
+241
+00:21:00,480 --> 00:21:04,580
+من الخلايا يعني الـ Hemoglobin أو الـ Red Blood
+
+242
+00:21:04,580 --> 00:21:08,190
+Cells، الـ Erythropoietin هو الـ Growth Factor تبعه
+
+243
+00:21:08,190 --> 00:21:13,230
+أو مثلاً نقول الـ Azenophils هم الـ Interleukin-5
+
+244
+00:21:13,230 --> 00:21:17,970
+هو اللي بيخليهم يكونوا يتنشطوا مثلاً، ففي Growth
+
+245
+00:21:17,970 --> 00:21:20,910
+Factors بس الـ Growth Factor حتى يشتغل وهو برا
+
+246
+00:21:20,910 --> 00:21:26,450
+لازم يكون له Receptor على الـ Cell Surface فدولة
+
+247
+00:21:26,450 --> 00:21:29,790
+في عندي Growth Factors بس خلوني يصير عندي الـ
+
+248
+00:21:29,790 --> 00:21:32,950
+Controlled Proliferation اللي بيعطيني الـ Function
+
+249
+00:21:32,950 --> 00:21:38,780
+المطلوبة وبعدين لما تصير مثلاً بالـ Hematopoiesis
+
+250
+00:21:38,780 --> 00:21:45,020
+للـ White والـ Red والـ Platelets of the blood
+
+251
+00:21:45,020 --> 00:21:49,420
+cells، الـ Terminal Differentiation لأنه فيه أنه
+
+252
+00:21:49,420 --> 00:21:54,020
+Transcription Factors وفيه أنه Apoptosis زي أخدته
+
+253
+00:21:54,020 --> 00:21:57,760
+عن الـ Fast Fast Ligand Interaction. This is one of
+
+254
+00:21:57,760 --> 00:22:04,950
+the main Stimuli أو Direct Orders for Cells to Die
+
+255
+00:22:04,950 --> 00:22:09,450
+in Programmed Cell Death اللي هو الـ Apoptosis، الـ
+
+256
+00:22:09,450 --> 00:22:13,590
+Apoptosis مختلف عن الـ Necrosis، الـ Necrosis اللي
+
+257
+00:22:13,590 --> 00:22:20,130
+هو بيكون الخلية بتموت بانفجار وبكون يعني فيه
+
+258
+00:22:20,130 --> 00:22:24,270
+Inflammatory Response، الـ Apoptosis الخلية بتتحلل
+
+259
+00:22:24,270 --> 00:22:31,730
+بتتحول إلى كتل صغيرة من الأكل والـ والـ Proteins
+
+260
+00:22:31,730 --> 00:22:35,490
+والـ Amino Acids والـ Sugars والـ Lipids وبتلتَحَم
+
+261
+00:22:35,490 --> 00:22:39,270
+بالخلايا اللي حواليها، يعني الـ Apoptosis عادة في
+
+262
+00:22:39,270 --> 00:22:42,870
+تحت الميكروسكوب ما بنشوفه، ممكن نشوف الخلايا وهي
+
+263
+00:22:42,870 --> 00:22:50,510
+متقسمة، بس لما نِمُوت عادة ما بنشوفهاش كثير، فهذه
+
+264
+00:22:53,500 --> 00:22:58,560
+الخطوات الرئيسية والأساسية لعملية
+
+265
+00:22:58,560 --> 00:23:01,180
+(Repeated word "عملية" removed)
+
+266-271
+(Repeated word "عملية" removed)
+
+272
+00:23:06,800 --> 00:23:13,860
+عن طريق الـ DNA Repair
+
+273
+00:23:13,860 --> 00:23:18,560
+Proteins، فيه Certain Enzymes وCertain Molecules
+
+274
+00:23:18,560 --> 00:23:26,440
+اللي يعني تحفظ جودة الـ Replication من الـ DNA لكي
+
+275
+00:23:26,440 --> 00:23:31,280
+لا يحصل أي خطأ في القراءة، وبالنسبة لفيه الـ Process
+
+276
+00:23:31,280 --> 00:23:39,460
+of CBG DNA Methylation في Certain Sites أو
+
+277
+00:23:39,460 --> 00:23:40,920
+Hydroxymethylation
+
+278
+00:23:43,950 --> 00:23:48,830
+و DNA Modification Enzymes هاي بتمثل الـ Epigenetic
+
+279
+00:23:48,830 --> 00:23:53,030
+Control اللي هو بتحكم أي جروب من الجينات هم اللي
+
+280
+00:23:53,030 --> 00:23:55,810
+بيصير لهم الـ Gene Expression، مش كل الجينات
+
+281
+00:23:55,810 --> 00:23:59,210
+في كل الخلايا كلهم بيشتغلوا، لأ، في كل نوع من
+
+282
+00:23:59,210 --> 00:24:04,150
+الخلايا في certain genes that are activated، others
+
+283
+00:24:04,150 --> 00:24:08,090
+are suppressed، فهذا كله من خلال الـ Epigenetic
+
+284
+00:24:08,090 --> 00:24:13,340
+Control  (Repeated word "Control" removed) ويله الـ Many Mechanisms زي الـ DNA
+
+285
+00:24:13,340 --> 00:24:16,920
+Methylation، DNA Methylation، الـ Histone Modification
+
+286
+00:24:16,920 --> 00:24:22,600
+والـ mRNA Control، الـ Micro RNA Control، هدولة
+
+287
+00:24:22,600 --> 00:24:27,160
+كلهم Epigenetic Control، فكل هما دولة في
+
+288
+00:24:27,160 --> 00:24:33,540
+Interaction بينهم وبين بعض حتى يتم، لما نيجي نتطلع
+
+289
+00:24:33,540 --> 00:24:40,660
+على الـ Cancer Cells في عدة ملاحظات، هناك خسارة من
+
+290
+00:24:40,660 --> 00:24:45,900
+الـ Genomic Integrity، يعني ممكن أنا حكيتها مرة
+
+291
+00:24:45,900 --> 00:24:49,580
+قبل، إنه في certain cancers نلاقي بعض اللي لما
+
+292
+00:24:49,580 --> 00:24:56,480
+تاخد يعني هنا أنت أخذت نفس الخلايا السرطانية حاولت
+
+293
+00:24:56,480 --> 00:24:59,740
+تدرس شو فارقة بالـ DNA والـ Genetics أو الـ
+
+294
+00:24:59,740 --> 00:25:04,200
+Genomics عن الخلايا الطبيعية، ففيه Loss of
+
+295
+00:25:04,200 --> 00:25:11,600
+Genomic Integrity، Replication، Segregation مش
+
+296
+00:25:11,600 --> 00:25:16,540
+مظبوط، إحنا غلطنا، فـ DNA Replication Repair
+
+297
+00:25:16,540 --> 00:25:20,940
+Chromosome Stability and Segregation، Abnormal
+
+298
+00:25:20,940 --> 00:25:24,300
+Epigenetic Control، طبعاً يعني هنا الـ DNA Repair
+
+299
+00:25:24,300 --> 00:25:29,780
+Proteins يعني لما يكون هذا موجود، هي كارثة بتخلي
+
+300
+00:25:29,780 --> 00:25:36,520
+هذا الإنسان معرض جداً يكون عنده سرطان، في إيمان
+
+301
+00:25:36,520 --> 00:25:44,520
+بدأت تتكلم، احكي ماشي،
+
+302
+00:25:44,520 --> 00:25:52,540
+فبالنسبة لكل الـ Normal steps، if anomalies occur
+
+303
+00:25:52,540 --> 00:25:56,060
+أو if problems occur، سيسببون في النهاية الحصول على
+
+304
+00:25:56,060 --> 00:26:01,900
+الـ Cancer، (Repeated word "المصطلحات" removed)
+
+305-311
+(Repeated word "المصطلحات" removed)
+
+312
+00:26:26,440 --> 00:26:29,140
+متحكمين ممتازين من التحكم الطبيعي
+
+313
+00:26:29,140 --> 00:26:50,720
+(blank line removed)
+
+314
+00:26:54,380 --> 00:26:58,620
+اللي بوحدهم كلهم، Radiation، Chemicals، و Viral
+
+315
+00:26:58,620 --> 00:27:03,240
+Infection، و Drugs وغيره وغيره وغيره، بالأخير كلهم
+
+316
+00:27:03,240 --> 00:27:07,700
+بيخربوا الـ DNA، كلهم بيخربوا، بيشتغلوا على الـ…
+
+317
+00:27:07,700 --> 00:27:13,060
+الـ… الـ Gene Axis تبع الـ Cell Division من جهة
+
+318
+00:27:13,060 --> 00:27:17,880
+والـ Cell Proliferation والـ Apoptosis والنقاط هذه
+
+319
+00:27:17,880 --> 00:27:24,510
+فهي الـ General View of the Lecture، منعقد الموضوع
+
+320
+00:27:24,510 --> 00:27:32,810
+أكثر ونحكي بعض الأمثلة، أيها الكريم، احكي الله عفوك
+
+321
+00:27:32,810 --> 00:27:37,350
+يا دكتور، الله عفوك، فضل، بالنسبة لخلايا السرطان
+
+322
+00:27:37,350 --> 00:27:40,370
+اللي نزلت عنها في الـ Study اللي حدثت، مش هارد أن
+
+323
+00:27:40,370 --> 00:27:42,990
+تكون الخلل في كل مراحل الـ cycle أو في كل مراحل
+
+324
+00:27:42,990 --> 00:27:47,050
+الـ kill على طول حياتها عشان تكون في الخلل في مرحلة
+
+325
+00:27:47,050 --> 00:27:52,590
+واحدة، نعم، عيد السؤال وعلي صوتك، قريباً أنا رافع
+
+326
+00:27:52,590 --> 00:27:56,890
+صوتي، عندي على خير، مش سامعك كثير، كله إن الخلايا
+
+327
+00:27:56,890 --> 00:28:01,230
+السرطانية كمان عندها cell cycle، طبعاً، بس هذا فيه
+
+328
+00:28:01,230 --> 00:28:06,810
+abnormality، عادة الـ cycle، ولكن عشان يصير مثلاً،
+
+329
+00:28:06,810 --> 00:28:11,270
+يصير lung cancer أو أي سرطان مثلاً في أي خلية،
+
+330
+00:28:11,270 --> 00:28:14,390
+لازم يصير خلل، مش شرط كل الـ cycle فيه خلل، بس كيف
+
+331
+00:28:14,390 --> 00:28:19,060
+مرحلة واحدة يصير خلل، بدلة سرطان؟ لأ، لأ، لأ، لأ،
+
+332
+00:28:19,060 --> 00:28:26,780
+اسمع علي، إحنا بالأخير مثلاً مثلاً الـ Tissue زي
+
+333
+00:28:26,780 --> 00:28:34,680
+الـ Lung في مثلاً نفترض مليون خلية، مثلاً نفترض هيك
+
+334
+00:28:34,680 --> 00:28:40,700
+هذول، الأصل إنه مثلاً يعني تقريباً واحدة بالألف من
+
+335
+00:28:40,700 --> 00:28:46,480
+كل خلية بتنقسم مرة باليوم، فإنت المتوقع إنه منها
+
+336
+00:28:46,480 --> 00:28:52,080
+المليون فيه ألف كل يوم بنقسمه، بس حتى تكون الأمور
+
+337
+00:28:52,080 --> 00:28:54,880
+stable وتشوف الـ tissue زي ما هو، يعني أنا مثلاً
+
+338
+00:28:54,880 --> 00:29:02,720
+الجلد عندي أنا شايفه نفس الحجم، ما اختلفش، فاللي
+
+339
+00:29:02,720 --> 00:29:09,960
+بيصير أن هالألف اللي انقسموا وصاروا ألفين، مقابلهم
+
+340
+00:29:09,960 --> 00:29:16,310
+فيه ألف راح يموت، بحيث إنه يظل الرقم مليون ويظل كل
+
+341
+00:29:16,310 --> 00:29:22,130
+يوم ألف يولدوا جديد، يعني تكون ألفين جديد ونخسر
+
+342
+00:29:22,130 --> 00:29:26,590
+ألف بالـ Apoptosis ويظل العدد زي ما هو، لما تقول
+
+343
+00:29:26,590 --> 00:29:33,010
+سرطان، أنت هذا المليون في مكان صار مليون وربع،
+
+344
+00:29:33,010 --> 00:29:38,090
+مليون ونصف، مليونين، ثلاثة ملايين، أربعة ملايين، فعدد
+
+345
+00:29:38,090 --> 00:29:43,990
+الخلايا عادة بيزيد، ممكن هذا لأن الانقسام صار أسرع أو
+
+346
+00:29:43,990 --> 00:29:50,150
+إن الخلايا بطّلت تموت، يعني إنت كان عندك ألف صاروا
+
+347
+00:29:50,150 --> 00:29:54,270
+ألفين لأن ألف خلية انقسمت، بس بدل ما يموت ألف مات
+
+348
+00:29:54,270 --> 00:30:00,430
+خمسمئة، فبتصير أنت بالمحصلة عندك بدل ما هو ألف صار
+
+349
+00:30:00,430 --> 00:30:05,930
+ألف وخمسماية زيادة، فلما تشوف أنت tumor معناته يا
+
+350
+00:30:05,930 --> 00:30:13,570
+إما increased cell division أو Decreased Apoptosis
+
+351
+00:30:13,570 --> 00:30:19,010
+وبالأخير، حتى يصير ورم، يعني كتلة إضافية مش الكتلة
+
+352
+00:30:19,010 --> 00:30:22,030
+النمو الطبيعي اللي بدك إياه أو اللي موجود أو الـ
+
+353
+00:30:22,030 --> 00:30:27,470
+Control، فحتى يكون هذا، عدد الخلايا لازم يزيد، يعني
+
+354
+00:30:27,470 --> 00:30:31,450
+هي فيها تلقائي راح تكون، إن شاء الله واضح يا كريم
+
+355-356
+(Repeated word "دعوني أسألك" removed)
+
+357
+00:30:42,810 --> 00:30:47,530
+أه، مالك؟ هل جيت أنت قُلت اللي بقى اللي فيها الـ
+
+358
+00:30:47,530 --> 00:30:53,790
+cancer؟ أه الأولى؟ لأ، الرابعة، الرابعة تصبح الـ
+
+359
+00:30:53,790 --> 00:30:58,610
+رابعة فيها الـ… في الرابعة، أه، هل جيتها عشان فيه
+
+360
+00:30:58,610 --> 00:31:02,970
+خلل فيها cancer أو فيه فيها normal growth؟ لازم
+
+361
+00:31:02,970 --> 00:31:05,410
+في خلال في مرحلة واحدة من المراحل؟ ولا كل مراحل
+
+362
+00:31:05,410 --> 00:31:12,420
+هذه لازم فيها خلل؟ يا دكتور، في كل نوع من السرطانات
+
+363
+00:31:12,420 --> 00:31:18,000
+فيه بشكل أو أوضح وأكبر يمكن إنه نوع معين من الـ
+
+364
+00:31:18,000 --> 00:31:21,620
+Anomalies مش كلهم راح تلاقيهم في كل أنواع
+
+365
+00:31:21,620 --> 00:31:26,300
+السرطانات، أو لازم كلهم يكونوا، وفي الغالب ما بيكون
+
+366
+00:31:26,300 --> 00:31:30,520
+في أي سرطان بس واحدة هي اللي فيها خلل، لازم يكون،
+
+367
+00:31:30,520 --> 00:31:36,010
+حكيت لك Multifactorial يعني فيها أكثر من جانب، بس
+
+368
+00:31:36,010 --> 00:31:39,770
+اللي، اللي، اللي راح نحكي عنه دلوقتي كأمثلة أكثر
+
+369
+00:31:39,770 --> 00:31:46,190
+يعني هاي لكل أنواع السرطانات بشكل عام، ماشي، هسه
+
+370
+00:31:46,190 --> 00:31:51,110
+لما نيجي ناخذ سرطان معين كمثال يمكن الآن اللي
+
+371
+00:31:51,110 --> 00:31:56,250
+اكتشفناه مثلاً جانب معين بشكل أو أوضح، بس هو في الأخير
+
+372
+00:31:56,250 --> 00:32:02,550
+حتى يصير السرطان لازم يكون في عندي مشكلة في أحد
+
+373
+00:32:02,550 --> 00:32:08,250
+هذه الجوانب، فيه تفاوت يمكن في حسب ما هو حسب أنت شو
+
+374
+00:32:08,250 --> 00:32:15,290
+درسته، ودراسة هذه المواضيع للأسف صعبة جداً، يعني إنك
+
+375
+00:32:15,290 --> 00:32:22,880
+أنت تكون عندك قدرة مثلاً والله أشوف الـ DNA repair
+
+376
+00:32:22,880 --> 00:32:26,680
+أو replication في السرطان اللي فلان بدي أخد
+
+377
+00:32:26,680 --> 00:32:30,680
+الخلايا وبدي أعيشهم في المختبر وبدي أخليهم
+
+378
+00:32:30,680 --> 00:32:33,880
+ينقسموا وبدي أدرس الـ repair ولا
+
+379
+00:32:33,880 --> 00:32:38,540
+الـ replication ولا بدي كذا، يعني هي أمر بيستهلك،
+
+380
+00:32:38,540 --> 00:32:46,450
+بس الفكرة أن هذا اللي موجود في كل عموم السرطانات، هي
+
+381
+00:32:46,450 --> 00:32:50,850
+ملخص لكل أنواع السرطانات يكون فيه لازم يكون أكثر
+
+382
+00:32:50,850 --> 00:32:56,950
+من مشكلة واحدة، يعني في الغالب مش مشكلة وحيدة فقط
+
+383
+00:32:56,950 --> 00:33:00,830
+يعني دائماً السرطانات والـ Autoimmune Diseases
+
+384
+00:33:00,830 --> 00:33:06,530
+بيقولوا عنها إن فيها Multifactorial Pathology يعني
+
+385
+00:33:06,530 --> 00:33:13,330
+تسبب فيها خلل من أكثر من جهة، ماشي، هذه ناحية،
+
+386
+00:33:13,330 --> 00:33:18,630
+الناحية الثانية يعني قيمة الدراسة هذه وفهم هذا
+
+387
+00:33:18,630 --> 00:33:23,470
+المواضيع زي ما راح نحكي في جزء منه في الأخير، قضية
+
+388
+00:33:23,470 --> 00:33:30,150
+إنه إذا اكتشفت إنه لنوع سرطان معين، a certain
+
+389
+00:33:30,150 --> 00:33:36,790
+pathology is the most important، واستطعت to develop
+
+390
+00:33:36,790 --> 00:33:41,050
+a certain type of drug or treatment to counteract
+
+391
+00:33:41,050 --> 00:33:48,060
+it، to change it، ربما يكون لديك إجابة أو إجابة يعني
+
+392
+00:33:48,060 --> 00:33:51,000
+زي راح ناخد بعدين الـ Transcription Factor
+
+393
+00:33:51,000 --> 00:33:55,640
+Inhibitor، الـ Tyrosine Kinase Inhibitor، هدولة في
+
+394
+00:33:55,640 --> 00:34:00,840
+بعض أنواع السرطانات ممتازة جداً ويعني فتح وطيور
+
+395
+00:34:00,840 --> 00:34:06,300
+علاج خيالي، يعني بتعتبره، فالفهم المواضيع هذه
+
+396
+00:34:06,300 --> 00:34:11,340
+المقصود الآن في المرحلة هذه إنه إحنا لازم يكون
+
+397
+00:34:11,340 --> 00:34:16,510
+عندنا استيعاب لشو هي الخطوات المسببة للسرطان
+
+398
+00:34:16,510 --> 00:34:23,830
+وبالتالي هي نوع من الاحتماليات أو تعطينا أفكار على
+
+399
+00:34:23,830 --> 00:34:29,410
+كيفية علاجه، ورح ناخذ أمثلة عليه، الآن ما بتكلم عن
+
+400
+00:34:29,410 --> 00:34:34,490
+سرطان محدد، وكل أنواع خلايا الجسم ممكن تتحول
+
+401
+00:34:34,490 --> 00:34:39,350
+للسرطانية، يعني المكان الوحيد اللي ما عمري سمعت إنه
+
+402
+00:34:39,350 --> 00:34:44,730
+بتتكون فيه سرطان هو الجزء الأول أو الثاني من الـ 12
+
+403
+00:34:44,730 --> 00:34:47,970
+(word removed)
+
+404
+00:34:47,970 --> 00:34:52,870
+هذا النوع، هذا المكان في الجسم من النادر أو عمري
+
+405
+00:34:52,870 --> 00:34:56,270
+ما سمعت إنه فيه سرطان في الـ Duodenum في هذا
+
+406
+00:34:56,270 --> 00:34:59,190
+المكان، سرطان في المريء، في الـ Oesophagus، في
+
+407
+00:34:59,190 --> 00:35:02,350
+الـ Small Intestine، بالـ Large Intestine، مش عارف
+
+408
+00:35:02,350 --> 00:35:07,330
+إيش، بتلاقي كل أنواع الجسم بتلاقي فيه سرطانات، جلد،
+
+409
+00:35:07,330 --> 00:35:12,850
+دم، أعصاب، عظام، أي نوع خلايا بيمكن تتحول للسرطان
+
+410
+00:35:12,850 --> 00:35:21,910
+وهي كله بيكون في الـ… شو اسمه؟ بيكون من الـ…
+
+411
+00:35:21,910 --> 00:35:27,250
+الـ
+
+445
+00:38:29,420 --> 00:38:33,860
+من قطعة ثانية راح نأخذ مثال عليها، الـPhiladelphia
+
+446
+00:38:33,860 --> 00:38:38,700
+chromosome نسميه، بيكون اللي بيطلع عندي بروتين
+
+447
+00:38:38,700 --> 00:38:43,340
+مختلف تمامًا، وظيفته أحيانًا مختلفة، وأحيانًا في عندي
+
+448
+00:38:43,340 --> 00:38:47,980
+gene amplification هنا نفس الـgene ككمية بس
+
+449
+00:38:47,980 --> 00:38:52,380
+الوظيفة صارت أقوى بكثير، وأحيانًا بيكون أنه بيصير
+
+450
+00:38:52,380 --> 00:38:57,420
+عندي amplification بدل ما يكون عندي one copy of
+
+451
+00:38:57,420 --> 00:39:01,600
+that gene بيصير عندي multiple copies، ويكون بالتالي
+
+452
+00:39:01,600 --> 00:39:05,420
+إذا كلهم صار لهم transcription، فهيصير برضه عندي
+
+453
+00:39:05,420 --> 00:39:08,560
+excessive amount of the protein، which is normal أو
+
+454
+00:39:08,560 --> 00:39:13,790
+similar to the original protein. هذه كلها ميكانيزمات
+
+455
+00:39:13,790 --> 00:39:17,130
+ميوتيشيالية تؤدي إلى اكتفاء البروتو-أونكوجين
+
+456
+00:39:17,130 --> 00:39:21,550
+أحيانًا تحصل عندها اكتفاء كبير في أماكن معينة،
+
+457
+00:39:21,550 --> 00:39:27,890
+وتكون نتيجة أنواع الاختلالات هذه سواء في الـCoding
+
+458
+00:39:27,890 --> 00:39:32,250
+Mutation أو الـRegulatory Mutation أو التغيير أو
+
+459
+00:39:32,250 --> 00:39:36,230
+التعيين من مجموعة أخرى مع مفعول بروتين جديد أو
+
+460
+00:39:36,230 --> 00:39:40,780
+بروتين جديد يعمل أكثر أو أقل أو على الـGene
+
+461
+00:39:40,780 --> 00:39:47,740
+Amplification. فهذه ميكانيزمات مختلفة، إحنا عادةً
+
+462
+00:39:47,740 --> 00:39:52,360
+الـNormal Cell نتوقعها
+
+463
+00:39:52,360 --> 00:39:58,260
+تظل بشكل معيّار. الـStages بيحصل أولاً بـIncreased
+
+464
+00:39:58,260 --> 00:40:02,760
+Proliferation، وبتكون إنه صار عندي خلل في مكان A
+
+465
+00:40:04,210 --> 00:40:08,950
+وبعدين صار عندي mutation in site B، وبعدين عندي
+
+466
+00:40:08,950 --> 00:40:13,410
+mutation في الـthird place. يعني اللي بدنا واحد
+
+467
+00:40:13,410 --> 00:40:20,390
+يتذكره إنه إحنا في الغالب ما بنتكلم عن إنه single
+
+468
+00:40:20,390 --> 00:40:24,230
+thing that will lead to the cancer، it has to be at
+
+469
+00:40:24,230 --> 00:40:28,670
+multiple sites. وبالتالي بعد الـincrease
+
+470
+00:40:28,670 --> 00:40:33,140
+proliferation مثلًا في الـGI بيعطينا مثلًا الـ
+
+471
+00:40:33,140 --> 00:40:37,200
+Benign Adenoma. الـAdenoma بتكون إنه إزالة الـ
+
+472
+00:40:37,200 --> 00:40:39,900
+proliferation، وبتكون it's a benign looking thing.
+
+473
+00:40:39,900 --> 00:40:44,880
+هذه بتصير Early Neoplasia، Progressive Neoplasia،
+
+474
+00:40:44,880 --> 00:40:48,600
+مع الـprogression أكثر، بيصير عندي بالأخير الـ
+
+475
+00:40:48,600 --> 00:40:53,360
+Carcinoma، والأسوأ نوع اللي هو بيروح بالـmetastasis، يعني
+
+476
+00:40:53,360 --> 00:40:56,940
+بتطور أكثر لأنه يصير Endometastasis، and this is
+
+477
+00:40:56,940 --> 00:41:04,400
+way different than the normal cell. غير الـ
+
+478
+00:41:04,400 --> 00:41:09,380
+Mutations في Multiple Genes، الـChromosomal
+
+479
+00:41:09,380 --> 00:41:17,000
+Aneuploidy. يعني أنا إذا الـNormal Tissue بشوف
+
+480
+00:41:17,000 --> 00:41:24,060
+الخلايا 2N doing their work، وStable، وبتكون
+
+481
+00:41:24,060 --> 00:41:30,630
+حالياً بتكون  Functional وكويسة. الـcancer cells
+
+482
+00:41:30,630 --> 00:41:34,670
+وبالذات لما نكون كل ما هو more advanced، more
+
+483
+00:41:34,670 --> 00:41:42,810
+metastatic، more aggressive، ماشي، بنلاقي increased
+
+484
+00:41:42,810 --> 00:41:46,910
+genetic anomalies including chromosomal aneuploidy.
+
+485
+00:41:46,910 --> 00:41:53,590
+يعني الـDNA repair و modification والـchromatin
+
+486
+00:41:53,590 --> 00:41:57,620
+modification، الـgenes. هذا بالأول، بس كل ما هذه
+
+487
+00:41:57,620 --> 00:42:02,320
+الخلايا بتتكاثروا بسرعة كبيرة، السرعة بتخلي احتمالية
+
+488
+00:42:02,320 --> 00:42:06,620
+الأخطاء تصير أكبر، وهنا بتصير الأخطاء أكثر على
+
+489
+00:42:06,620 --> 00:42:11,360
+مستوى الـChromosomes كلها، مش بس Single Gene أو الـ
+
+490
+00:42:11,360 --> 00:42:16,950
+Proto-Oncogene الأول بس. فبالتالي لما واحد يشوف الـ
+
+491
+00:42:16,950 --> 00:42:20,590
+Advanced Cancer مثلًا اللي موجود في الـMetastasis
+
+492
+00:42:20,590 --> 00:42:26,550
+بسهولة بيلاقي 3N، 4N، 8N of Genetic Material.
+
+493
+00:42:26,550 --> 00:42:31,870
+Highly Abnormal، ويكون هذا جزء من الـ
+
+494
+00:42:31,870 --> 00:42:38,230
+Aggressiveness. يعني ليش السرطان هذا سيء وشرس
+
+495
+00:42:38,230 --> 00:42:42,230
+وبيهاجم بسرعة وبينتشر بسرعة؟ فبيكون لأن الـ
+
+496
+00:42:42,230 --> 00:42:44,770
+Control على الجينات ضعيف جدًا.
+
+497
+00:42:47,210 --> 00:42:57,950
+فـI think this يعني slide أو يعني الفكرة تبعته
+
+498
+00:42:57,950 --> 00:43:05,730
+إنه regardless of whatever cancer، wherever the
+
+499
+00:43:05,730 --> 00:43:10,170
+cancer occurs، sporadically أو individually أو نتيجة
+
+500
+00:43:10,170 --> 00:43:12,770
+من ميوتاشين أو مستلزمة أو مستلزمة أو مستلزمة أو
+
+501
+00:43:12,770 --> 00:43:13,030
+مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو
+
+502
+00:43:13,030 --> 00:43:14,650
+مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو
+
+503
+00:43:14,650 --> 00:43:15,030
+مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو
+
+504
+00:43:15,030 --> 00:43:16,660
+مستلزمة أو مستلزمة أو مستلزمة، يعني حكينا أو يمكن راح
+
+505
+00:43:16,660 --> 00:43:22,580
+نحكي بعد شوية، إنه السرطان أحيانًا فيه أشياء منه
+
+506
+00:43:22,580 --> 00:43:27,920
+genetic وinherited. يعني راح نأخذ أمثلة عليها، وبعض
+
+507
+00:43:27,920 --> 00:43:32,880
+الأشياء الموجودة ومعروفة، ممكن واحد يدرسها في
+
+508
+00:43:32,880 --> 00:43:39,920
+certain families. فسواء هو individually أو سواء هو في
+
+509
+00:43:39,920 --> 00:43:48,660
+family أو كـHereditary trait، بالأخير السرطان هو
+
+510
+00:43:48,660 --> 00:43:54,700
+Genetic Phenomenon، Genetic Disease، لأنه سواء الـ
+
+511
+00:43:54,700 --> 00:43:59,480
+Oncogene بالـindividual أو إذا بالـFamily ويكون
+
+512
+00:43:59,480 --> 00:44:03,840
+أحيانًا فيه tumor suppressor gene على عكس الـ
+
+513
+00:44:03,840 --> 00:44:11,280
+Oncogenes. يعني الـGenes involved in cancer تكون من
+
+514
+00:44:11,280 --> 00:44:15,420
+نوعين مختلفين: في الـOncogenes اللي بيزيدوا السرطان
+
+515
+00:44:15,420 --> 00:44:19,200
+وفي الـTumor Suppressor Genes، وكثير من الـGenes
+
+516
+00:44:19,200 --> 00:44:25,260
+ومهمتهم هو تقليل الـCancer. فإذا هذا النوع من الـ
+
+517
+00:44:25,260 --> 00:44:30,000
+Genes صار له Suppression، صار له Inhibition
+
+518
+00:44:30,000 --> 00:44:34,680
+وSuppression لـTumor Suppressor Genes، فنفي النفي
+
+519
+00:44:34,680 --> 00:44:41,700
+إيجاب، وبالتالي بيصير عندي السرطان. فهي يعني أنا بظن
+
+520
+00:44:41,700 --> 00:44:50,140
+اقرأوا الجزء هذا، ويعني هذه مفاهيم مهمة، تداخل بين
+
+521
+00:44:50,140 --> 00:44:57,800
+الـgenes وبالنسبة للـ يعني different types of
+
+522
+00:44:57,800 --> 00:45:03,720
+problems with different types of cancer.
+
+523
+00:45:06,060 --> 00:45:10,820
+من الأشياء اللي حكينا عنها، أحيانًا في certain،
+
+524
+00:45:10,820 --> 00:45:15,300
+many types of genes and for different types of
+
+525
+00:45:15,300 --> 00:45:22,520
+cells، أنه for any type of cell to either divide أو
+
+526
+00:45:22,520 --> 00:45:28,340
+أحيانًا  Apoptosis أو do anything، it starts with a
+
+527
+00:45:28,340 --> 00:45:31,740
+certain stimulus اللي هو الـHormone اللي بدنا
+
+528
+00:45:31,740 --> 00:45:38,140
+نسميه الـLigand. هنا الـL for Ligand. فالـLigand حتى
+
+529
+00:45:38,140 --> 00:45:44,220
+يشتغل بذاته، الـprotein hormones، إذا كربوهيدرات، إذا
+
+530
+00:45:44,220 --> 00:45:46,460
+lipid، كربوهيدرات، كربوهيدرات، كربوهيدرات، كربوهيدرات،
+
+531
+00:45:46,460 --> 00:45:47,300
+كربوهيدرات، كربوهيدرات، كربوهيدرات، كربوهيدرات، كربوهيدرات،
+
+532
+00:45:47,300 --> 00:45:48,060
+كربوهيدرات، كربوهيدرات، كربوهيدرات، كربوهيدرات، كربوهيدرات،
+
+533
+00:45:48,060 --> 00:45:50,900
+كربوهيدرات، كربوهيدرات، كربوهيدرات، كربوهيدرات، كربوهيدرات،
+
+534
+00:45:50,900 --> 00:45:54,080
+كربوهيدرات، كربوهيدرات، كربوهيدرات، كربوهيدرات، كربوهيدرات،
+
+535
+00:45:54,080 --> 00:45:58,840
+كربوهيدرات، كربوهيدرات،
+
+536
+00:45:58,840 --> 00:46:08,950
+كربو... الـCell Surface Receptor مرات كثيرة بيكون يعني
+
+537
+00:46:08,950 --> 00:46:15,230
+شوي متباعد عن بعضه. لما يصير Interaction بين الـ
+
+538
+00:46:15,230 --> 00:46:21,910
+Cell Surface Receptor مع الـLigand تبعه، بيصير
+
+539
+00:46:21,910 --> 00:46:27,730
+بيقولوا له "conformational change"، يعني شكل البروتين
+
+540
+00:46:27,730 --> 00:46:33,200
+بيَتغير، بنضبط على بعض، وبيَتغير. فهنا المثال اللي حاطينه
+
+541
+00:46:33,200 --> 00:46:37,440
+إنه بعد ما كانت الـtwo chains بعيد عن بعض، صار
+
+542
+00:46:37,440 --> 00:46:44,580
+قريبين و became activated. مرات كثيرة بيكون الـ
+
+543
+00:46:44,580 --> 00:46:48,640
+enzyme which is a kinase، اللي هو يعني وظيفة، وظيفة
+
+544
+00:46:48,640 --> 00:46:58,810
+phosphate على الـgroup بيكون incorporated إلى الـ
+
+545
+00:46:58,810 --> 00:47:05,550
+Cell Surface Receptor، يعني يكون جزء منه. فلما نكون
+
+546
+00:47:05,550 --> 00:47:08,770
+بعيد، بيكون هذا مش شغال. لما هدول القطعتين
+
+547
+00:47:08,770 --> 00:47:15,110
+بعيد عن بعض، بعد ما يشوف الـCell Surface Receptor
+
+548
+00:47:15,110 --> 00:47:19,370
+يشوف الـLigand أو الهرمون أو الـStimulus، بيصير
+
+549
+00:47:19,370 --> 00:47:24,210
+في Activation للفعلين، بنضيف الـunit of phosphate
+
+550
+00:47:24,210 --> 00:47:34,910
+on it. هذه نسميها steps of signal transduction. وهنا
+
+551
+00:47:34,910 --> 00:47:38,610
+حاطين مثال الـRetinoblastoma أو الـ
+
+552
+00:47:38,610 --> 00:47:39,550
+Retinoblastoma أو الـRetinoblastoma أو الـ
+
+553
+00:47:39,550 --> 00:47:39,990
+Retinoblastoma أو الـRetinoblastoma أو الـ
+
+554
+00:47:39,990 --> 00:47:41,070
+Retinoblastoma أو الـRetinoblastoma أو الـ
+
+555
+00:47:41,070 --> 00:47:42,990
+Retinoblastoma أو الـRetinoblastoma أو الـ
+
+556
+00:47:42,990 --> 00:47:44,410
+Retinoblastoma أو الـRetinoblastoma أو الـ
+
+557
+00:47:44,410 --> 00:47:44,550
+Retinoblastoma أو الـRetinoblastoma أو الـ
+
+558
+00:47:44,550 --> 00:47:47,310
+Retinoblastoma أو الـRetinoblastoma أو الـ
+
+559
+00:47:47,310 --> 00:47:49,870
+Retinoblastoma أو الـRetinoblastoma أو الـ
+
+560
+00:47:49,870 --> 00:47:56,010
+Retinoblastoma أو الـRetinoblastoma
+
+561
+00:47:56,010 --> 00:47:59,420
+أو الـRetino... التغيير في الوصول للإشارة بيصير
+
+562
+00:47:59,420 --> 00:48:04,520
+عندي recruitment of multiple proteins and
+
+563
+00:48:04,520 --> 00:48:08,600
+activate other kinases and small g-proteins that
+
+564
+00:48:08,600 --> 00:48:12,500
+in turn activate various transcription factors.
+
+565
+00:48:12,500 --> 00:48:20,360
+يعني بالأخير أنا لما مثلًا يجي هرمون على الـcell
+
+566
+00:48:20,360 --> 00:48:24,740
+surface وتشوف الخلية، بيتفاعل مع الـreceptor تبعه،
+
+567
+00:48:25,650 --> 00:48:29,110
+بالأخير إذا، بيصير عندي Cell Division أو New
+
+568
+00:48:29,110 --> 00:48:33,470
+Protein Function. لازم الـStimulus تصل الـNucleus
+
+569
+00:48:33,470 --> 00:48:41,630
+فتبدأ في الغالب بـKinases زي الـJak، الـJak Just
+
+570
+00:48:41,630 --> 00:48:45,830
+Another Kinase، زي ما بيقولوا، وظيفته إنه يعمل
+
+571
+00:48:45,830 --> 00:48:50,770
+Phosphorylation. فالـPhosphorylation هنا بعدين
+
+572
+00:48:50,770 --> 00:48:55,730
+بيكون خطوة أو أكثر هنا. بالأخير بيصير عندي
+
+573
+00:48:55,730 --> 00:48:59,790
+Transcription Factor، Transcription اللي هو Change
+
+574
+00:48:59,790 --> 00:49:07,950
+of DNA to RNA. يعني بيفتح الـDNA في محل معين بيصير
+
+575
+00:49:07,950 --> 00:49:14,750
+له Transcription لـMessenger RNA. فالـChanges هذه
+
+576
+00:49:15,600 --> 00:49:19,580
+بالأخير حتى يصير عندي Cancer، الـend result should
+
+577
+00:49:19,580 --> 00:49:23,000
+be to stimulate proliferation، to suppress
+
+578
+00:49:23,000 --> 00:49:27,620
+Apoptosis. واحدة منها، يعني يا هذه يا هذه، بطريقتين
+
+579
+00:49:27,620 --> 00:49:33,800
+هذول. فبالأخير إحنا بكل الحالات لازم نحاول نفهم
+
+580
+00:49:33,800 --> 00:49:41,370
+الـsteps هذه، وأحيانًا هذه بتعطينا بالأول رؤية ونظرة
+
+581
+00:49:41,370 --> 00:49:46,470
+وفهم ليش السرطان تكون، بس ممكن تعطينا حلول في
+
+582
+00:49:46,470 --> 00:49:50,050
+بعض أنواع السرطانات، زي ما راح نشوف كمان بعد شوية.
+
+583
+00:49:50,050 --> 00:49:54,110
+في أسئلة؟
+
+584
+00:49:54,110 --> 00:50:04,610
+الآن في أمثلة على الـTumor Suppressor Genes، يعني
+
+585
+00:50:04,610 --> 00:50:10,690
+الصراحة الأمثلة هذول والجينات اللي راح نحكي عنهم
+
+586
+00:50:10,690 --> 00:50:18,250
+ونلاحظ عليهم، أنه صرنا نعرف عنهم من دراسة خلايا
+
+587
+00:50:18,250 --> 00:50:27,390
+السرطانات وتبعات المرضى. يعني هنا حاطين في حالات
+
+588
+00:50:27,390 --> 00:50:32,390
+الـSporadic Cases، الـRetinoblastoma مثلًا لهذا
+
+589
+00:50:32,390 --> 00:50:40,740
+الأشياء. أنا بدي يعني أطلع على كل الجدول هذا، ماشي، بدي
+
+590
+00:50:40,740 --> 00:50:47,040
+بس تحفظوا Bracket 1 وBracket 2، ماشي، الـBracket 1
+
+591
+00:50:47,040 --> 00:50:55,080
+يعني حتى زي ما بيقول الواحد، يتذكرها يعني بدنا نطلع
+
+592
+00:50:55,080 --> 00:50:58,380
+شوية يعني هي في الطب يعني بس بدنا ندخل على التمثيل
+
+593
+00:50:58,380 --> 00:51:03,340
+شوية من الممثلات المشهورات، "واجهة على الأردن"
+
+594
+00:51:03,340 --> 00:51:07,280
+"زاروا مخيمات اللاجئين"، "ولها نشاط إنساني"
+
+595
+00:51:07,280 --> 00:51:15,140
+"أنجلينا جولي"، تسمعوا فيها صح؟ ممثلة مشهورة، اللي
+
+596
+00:51:15,140 --> 00:51:22,700
+حدا بيشوف أفلام بيلاقيها، يعني معروفة هذه الممثلة.
+
+597
+00:51:22,700 --> 00:51:26,380
+عندها "very strong family history of bilateral
+
+598
+00:51:26,380 --> 00:51:28,320
+breast cancer".
+
+599
+00:51:30,430 --> 00:51:35,730
+والـBRCA1 طلع Positive عندها، وTwo Doses، فعملت
+
+600
+00:51:35,730 --> 00:51:40,230
+Breast يعني Mastectomy Bilateral، وهي ما عندهاش
+
+601
+00:51:40,230 --> 00:51:46,470
+سرطانات. فالـ... الـ... بالذات الـBRCA1 و
+
+602
+00:51:46,470 --> 00:51:52,370
+BRCA2، إذا بدك تنسى بقية الأشياء ماشي، انساهن، بس
+
+603
+00:51:52,370 --> 00:51:57,590
+هدول احفظهن كمثال على هذا الأمر، ماشي.
+
+604
+00:51:59,870 --> 00:52:08,270
+فالـ... يعني راح نشوف بعدين كيف تم عملية اكتشاف إن
+
+605
+00:52:08,270 --> 00:52:12,050
+هذا الـgene هو المسؤول، أو شيء قريب من هذا المكان
+
+606
+00:52:12,050 --> 00:52:14,430
+هو المسؤول عن السرطان هذا.
+
+607
+00:52:18,220 --> 00:52:24,080
+فالأنواع يعني Retinoblastoma I، ولقوا بعدين الـ
+
+608
+00:52:24,080 --> 00:52:27,960
+protein تبعه. ثواني يا كريم، أخلص الجملة، وبعدين
+
+609
+00:52:27,960 --> 00:52:34,920
+بخليك تسأل. الـTP53 يعني لاحظوا الشغل، الـGene
+
+610
+00:52:34,920 --> 00:52:41,740
+دائمًا بحرف كبير، الـGene Product والبروتين
+
+611
+00:52:41,740 --> 00:52:46,860
+بيحطوه بحرف صغير أحيانًا. إحنا على الـMolecular
+
+612
+00:52:46,860 --> 00:52:53,220
+Weight يعني مثلًا مرات بيسموه protein بـ110 وزنه
+
+613
+00:52:53,220 --> 00:53:01,100
+110 kDa، protein بـGP 160، GP 120، GP 41 تبعين
+
+614
+00:53:01,100 --> 00:53:07,460
+الـHIV وغيره وغيره. فهي لها معاني بالنسبة لكيف على
+
+615
+00:53:07,460 --> 00:53:11,340
+شو بندور في الـ...
+
+616
+00:53:11,340 --> 00:53:16,220
+فيه a lot of cancers. We said they can be familial
+
+617
+00:53:16,220 --> 00:53:19,980
+ويكون يعني strong association with certain types
+
+618
+00:53:19,980 --> 00:53:26,060
+of genes، والـBRCA1 وBRCA2 بالـbreast cancer و
+
+619
+00:53:26,06
+
+667
+00:57:32,760 --> 00:57:38,280
+غيّرت الشكل أو الجسم خوفاً من السرطان لأنه فيه
+
+668
+00:57:38,280 --> 00:57:44,780
+familial incidents بشكل قويّ كتير، واضح؟
+
+669
+00:57:44,780 --> 00:57:47,980
+نعم، كنت أقول إنّ بقيت أملك الـ mastectomy جاب ما
+
+670
+00:57:47,980 --> 00:57:53,270
+يكون سرطان كنت بتبقى أعرف أن الـ «أندوطفرا» هذا كنت
+
+671
+00:57:53,270 --> 00:57:57,410
+طفرة أو استعمال كبير من الـGangster Cancer أه لأ،
+
+672
+00:57:57,410 --> 00:58:02,190
+بالذات الأنواع الـFamilial هي الطفرة موجودة
+
+673
+00:58:02,190 --> 00:58:07,570
+بالعائلة كلها، ماشي، في تفاوت أحياناً very
+
+674
+00:58:07,570 --> 00:58:10,610
+aggressive أحياناً very late، حسب إذا في أشياء
+
+675
+00:58:10,610 --> 00:58:16,110
+ثانية، بس النقطة كمان أتذكر أنّهمش بس واحدة كافية
+
+676
+00:58:16,110 --> 00:58:19,750
+حتّى يتكون سرطان لازم يكون أكثر من محل وأكثر من
+
+677
+00:58:19,750 --> 00:58:24,550
+مكانه، بس وجود شيء معيّن أحياناً إذا فيه سهولة أننا
+
+678
+00:58:24,550 --> 00:58:29,950
+ندرسها راح يكون very suggestive وممكن على ضوئها
+
+679
+00:58:29,950 --> 00:58:34,470
+الواحد يقرّر يعمل شيء preventive يعني زي ما حكينا
+
+680
+00:58:34,470 --> 00:58:37,770
+عن هذه الممثلة، وشو عندنا؟  ناشيء؟
+
+681
+00:58:40,910 --> 00:58:51,650
+الـ الـ فيه concept يعني أنا أظنّ كمان مهمّ بالنسبة
+
+682
+00:58:51,650 --> 00:58:56,790
+الـ Mendelian أو يعني الـ familial والـ inherited
+
+683
+00:58:56,790 --> 00:59:03,330
+forms of tumors وcancer، وأحياناً Sporadic المثال
+
+684
+00:59:03,330 --> 00:59:07,950
+يعني Retinoblastomas، الـ Retinoblastomas أحياناً
+
+685
+00:59:07,950 --> 00:59:13,060
+بيكون Familial، يعني تلاقيه موجودة في العائلة،
+
+686
+00:59:13,060 --> 00:59:32,620
+و…
+
+687
+00:59:35,280 --> 00:59:41,100
+بالنسبة لـ Mendelian type of inheritance بتكون الـ
+
+688
+00:59:41,100 --> 00:59:44,760
+suggestive أو الـ very clear single mutation
+
+689
+00:59:44,760 --> 00:59:49,280
+وبالتالي هنا مثلاً autosomal dominant males و
+
+690
+00:59:49,280 --> 00:59:52,960
+females وكل الـgeneration مصابين، فبالتالي هذه
+
+691
+00:59:52,960 --> 00:59:57,200
+autosomal dominant mutation
+
+692
+00:59:57,200 --> 01:00:04,980
+والنتيجة أنّ الـ tumors usually are multiple، يعني في
+
+693
+01:00:04,980 --> 01:00:10,500
+حالة الـDNA repair برضه mutation بيكون فيه skin
+
+694
+01:00:10,500 --> 01:00:14,760
+cancer وبيكون muscle cancer وبيكون كده بتلاقي
+
+695
+01:00:14,760 --> 01:00:19,060
+الـTumor في أكثر من محل وتكون bilateral وتكون
+
+696
+01:00:19,060 --> 01:00:26,460
+early onset طبعاً، إذا early onset و affects life
+
+697
+01:00:26,460 --> 01:00:31,730
+بشكل واضح، في الغالب ما راح تقدر العائلة تكمل
+
+698
+01:00:31,730 --> 01:00:37,390
+ويتكونوا هيك، يعني المصاب ما vintage يعني بس يعني
+
+699
+01:00:37,390 --> 01:00:42,510
+هاي الـ الـ الـ characteristics that tells you
+
+700
+01:00:42,510 --> 01:00:48,030
+that this mutation in the germ line أو in in يعني
+
+701
+01:00:48,030 --> 01:00:52,230
+is a Mendelian type of inheritance type of cancer
+
+702
+01:00:52,230 --> 01:00:58,660
+causation، في الـ sporadic في الغالب Single Tumors،
+
+703
+01:00:58,660 --> 01:01:03,280
+Unilateral، Later Onset ويكون Somatic Mutation
+
+704
+01:01:03,280 --> 01:01:08,280
+Multiple وبتيجي بعدين في الحياة لحيث إنّه شخص واحد
+
+705
+01:01:08,280 --> 01:01:12,740
+هو المصاب والبقية مش مصابة، فأحياناً بعض السرطانات
+
+706
+01:01:12,740 --> 01:01:17,740
+بتلاقيها إمّا Sporadic أو Familial أو Inherited
+
+707
+01:01:17,740 --> 01:01:22,660
+ويكون يعني اللي بدّي أستنتجه الواحد من هذا الكلام
+
+708
+01:01:22,660 --> 01:01:28,240
+إنّه في هذه الحالة المندليانية، الـ effect of that
+
+709
+01:01:28,240 --> 01:01:31,800
+single mutation is very powerful، is much stronger
+
+710
+01:01:31,800 --> 01:01:38,420
+من المطلوب، وبتكون هنا من الـ germline mutation
+
+711
+01:01:38,420 --> 01:01:42,660
+وهنا بدأنا بـ normal gene وصار عندي somatic
+
+712
+01:01:42,660 --> 01:01:46,880
+mutation، بدأنا هنا germline mutation و أدّتني شيء
+
+713
+01:01:46,880 --> 01:01:53,120
+ثاني، صوتها بزيادة وخبّصت المعضلة، هذول يعني برضه من
+
+714
+01:01:53,120 --> 01:01:59,720
+الطُّرق اللي بتحدث وبتكون موجودة، الـ two slides
+
+715
+01:01:59,720 --> 01:02:06,580
+هذول بيعطونا فكرة وهو دليل على إنّه السرطانات is
+
+716
+01:02:06,580 --> 01:02:15,560
+in part is familial أو is genetic، فيه variation في
+
+717
+01:02:15,560 --> 01:02:24,970
+الـ risk على كل نوع من السرطان في عائلة معيّنة، يعني
+
+718
+01:02:24,970 --> 01:03:02,820
+هنا بالأول، هنا one parent اللي affected بـ certain cancer، يعني if one parent is affected مثلاً cancer of the testicles، almost five times، الإنسان إذا واحد أبوه صار عنده سرطان الخصية، يصير هو عنده سرطان الخصية كمان five times more than the average population،
+
+723
+01:03:02,820 --> 01:03:08,000
+البقية برضه فيها نسبة أقل بالنسبة
+
+724
+01:03:08,000 --> 01:03:11,780
+إلى إذا فيه sibling، يعني أخ أو أخت، أقوى سرطان ممكن
+
+725
+01:03:11,780 --> 01:03:17,010
+الإنسان يصيبه هو thyroid gland cancer، يعني تقريباً 15 مرّة أكثر من
+
+726
+01:03:17,010 --> 01:03:22,210
+عادة، اللي هو الـ Standardized Incidence Ratio for
+
+727
+01:03:22,210 --> 01:03:29,450
+cancer، فالفكرة إذا الإنسان عنده Relatives أو
+
+728
+01:03:29,450 --> 01:03:33,050
+Relatives with certain types of cancer، you can
+
+729
+01:03:33,050 --> 01:03:37,590
+appreciate that they can have increased risk for
+
+730
+01:03:37,590 --> 01:03:40,850
+cancer، and part of this is because of shared
+
+731
+01:03:40,850 --> 01:03:46,700
+genetics، بس كمان بيظل عندي مبدأ إنّه ممكن الـ
+
+732
+01:03:46,700 --> 01:03:48,180
+«increased risk» «increased risk» «increased risk»
+
+733
+01:03:48,180 --> 01:03:48,740
+«increased risk» «increased risk» «increased risk»
+
+734
+01:03:48,740 --> 01:03:49,500
+«increased risk» «increased risk» «increased risk»
+
+735
+01:03:49,500 --> 01:03:52,980
+«increased risk» «increased risk» «increased risk»
+
+736
+01:03:52,980 --> 01:03:53,880
+«increased risk» «increased risk» «increased risk»
+
+737
+01:03:53,880 --> 01:04:05,360
+«increased risk» «increased risk»
+
+738
+01:04:05,360 --> 01:04:12,920
+ريسك
+
+739
+01:04:13,420 --> 01:04:20,600
+يعني يمكن تقريباً أربعين أو خمسين سنة، فيه بالذات
+
+740
+01:04:20,600 --> 01:04:26,360
+مرض أو سرطان الدم اللي هو «CML» اللي بيسمّوه
+
+741
+01:04:26,360 --> 01:04:32,520
+«Chronic Myeloid Leukemia»، سرطان الدم من نوع معيّن
+
+742
+01:04:32,520 --> 01:04:38,520
+وهو سرطان بطيء ومزمن، فهو «Chronic Myeloid
+
+743
+01:04:38,520 --> 01:04:45,740
+Leukemia» «CML»، لاحظنا فيهم هذول كمثال على الـ
+
+744
+01:04:45,740 --> 01:04:51,980
+كمثال على الـ Genetic Anomaly إنّه فيه عندهم شيء
+
+745
+01:04:51,980 --> 01:04:55,960
+اسمه Philadelphia chromosome، بالذات هذا السرطان
+
+746
+01:04:55,960 --> 01:05:00,580
+يعني راح نتكلم عنه، لأنه فيه أشياء specific له
+
+747
+01:05:00,580 --> 01:05:15,710
+أكثر، يعني محدّدة أكثر وبتكون يعني اللي بتكون ال…
+
+748
+01:05:15,710 --> 01:05:21,790
+يعني راح نحكي عنه نوع من العلاج له، نتيجة فهمنا
+
+749
+01:05:21,790 --> 01:05:29,870
+للـ Pathogenesis تبع الـ Disease فيه
+
+750
+01:05:29,870 --> 01:05:37,520
+Two Genes، واحد اسمه الـ B-cell receptor اللي هو PCR
+
+751
+01:05:37,520 --> 01:05:40,940
+يعني الـ Associated Protein with the B-cell
+
+752
+01:05:40,940 --> 01:05:43,460
+receptor، اللي تبع الـ Immunoglobulin بس هو مش الـ
+
+753
+01:05:43,460 --> 01:05:49,000
+Immunoglobulin، هو أنا في إيش ذوب PCR، فالـ PCR هذا
+
+754
+01:05:49,000 --> 01:05:55,560
+موجود على كروموزوم 22، وفي another gene برضه related
+
+755
+01:05:55,560 --> 01:06:03,170
+to the Hematologic Series أو الـ Blood Cell، الـ
+
+756
+01:06:03,170 --> 01:06:10,550
+White وحتّى الـ Red Blood Cell على كروموزوم 9، اسمه
+
+757
+01:06:10,550 --> 01:06:15,430
+ABL-1، فالّذين
+
+758
+01:06:15,430 --> 01:06:19,970
+لاحظوا من الأول وحتّى قبل ما يفهموا ليش الأمر بتمّ
+
+759
+01:06:19,970 --> 01:06:27,340
+في الـCML بهذا الشكل، إنّه لديهم لقوا Translocation
+
+760
+01:06:27,340 --> 01:06:36,640
+يعني فيه segment من كروموزوم 22، هذه الـ long arm
+
+761
+01:06:36,640 --> 01:06:43,820
+بتيجي وبتشبك على كروموزوم 9، قريبة بين هذه
+
+762
+01:06:43,820 --> 01:06:47,580
+بحيث اللي لقوا إنّ اللي عندهم هذا النوع من السرطان
+
+763
+01:06:47,580 --> 01:06:55,100
+الـ mutation عندهم إنّه بيصير عندي Translocation زي
+
+764
+01:06:55,100 --> 01:07:00,600
+الـ Chromosome 22 على الـ Chromosome 9، وبتصير عندي
+
+765
+01:07:00,600 --> 01:07:10,720
+بيقرب الـ VCR على الـ AVL1، فالـ VCR AVL1 هو
+
+766
+01:07:10,720 --> 01:07:16,820
+البروتين الجديد، الـ Product تبعه، ولأنه دخل بالـ
+
+767
+01:07:16,820 --> 01:07:21,900
+VCR يعني بالـ B Cell Surface Receptor، بيخلّي أنّه
+
+768
+01:07:21,900 --> 01:07:28,480
+بيخرّب الخلايا الدم بحيث إنّه بيكون نوع من السرطانات
+
+769
+01:07:28,480 --> 01:07:33,380
+محدّد أو بشكل معيّن، اسمه الـCML، ويكون عندي
+
+770
+01:07:33,380 --> 01:07:37,780
+Translocation بين هذول الـTwo Points، والنتيجة إنّ
+
+771
+01:07:37,780 --> 01:07:45,720
+الـABL1 جين والبروتين تبعه يصير يشبك مع الـPCR
+
+772
+01:07:48,160 --> 01:07:53,660
+جين وبروتين، حيث تصير عندك ناتج جين أو ناتج
+
+773
+01:07:53,660 --> 01:07:57,980
+بروتين بتطلع وهو اللي بيظنّ إنّه بيخلّي الخلايا ما
+
+774
+01:07:57,980 --> 01:08:02,720
+تموت وبيخلّي السرطان يتشوّر، فهذا هو
+
+775
+01:08:02,720 --> 01:08:08,140
+الـPhiladelphia Chromosome هو لـ«ماليقننسيّة
+
+776
+01:08:08,140 --> 01:08:12,540
+كينيطولوجية» من نوع معيّن، أحياناً حتّى بيساعدنا إنّه
+
+777
+01:08:12,540 --> 01:08:18,900
+نتشخّص شو نوعية الخلية اللي عاملة المشكلة، وفي عندها
+
+778
+01:08:18,900 --> 01:08:22,820
+هذه الأشياء، وهذه كمان ملاحظة في كثير من الـ
+
+779
+01:08:22,820 --> 01:08:27,640
+hematologic malignancies، أحنا هاي اللمفومة، الـ
+
+780
+01:08:27,640 --> 01:08:31,280
+acute lymphoplastic leukemia، acute lymphoplasty
+
+781
+01:08:31,280 --> 01:08:36,640
+اللي فيه more than for acute lymphoplastic، acute
+
+782
+01:08:36,640 --> 01:08:42,120
+promyelocytic اللي قابلني ALL7A3
+
+783
+01:08:42,120 --> 01:08:46,640
+لـpromyelocytic أو chronic lymphocytic leukemia أو
+
+784
+01:08:46,640 --> 01:08:50,360
+Follicular lymphoma أو Burkitt lymphoma، طبعاً يعني
+
+785
+01:08:50,360 --> 01:08:53,580
+المبدأ
+
+786
+01:08:53,580 --> 01:08:57,860
+الأساسي يجب أن تتذكروا كلمة leukemia يعني سرطان في
+
+787
+01:08:57,860 --> 01:09:02,700
+الدم، لما نفس الخلايا بتكون لسه بالـ lymph node
+
+788
+01:09:02,700 --> 01:09:07,840
+وما وصلت الدم نسمّيها lymphoma، ففي Burkitt، Hodgkin،
+
+789
+01:09:07,840 --> 01:09:11,220
+Non-Hodgkin، الـBurkitt هو من نوع من الـNon-Hodgkin
+
+790
+01:09:11,220 --> 01:09:15,630
+lymphoma، فسِهم كلّهم نفس الخلايا، وهذول بيكون عندي
+
+791
+01:09:15,630 --> 01:09:23,030
+Translocation، وفي تفاوت بالـ percentages، الـ cases
+
+792
+01:09:23,030 --> 01:09:29,670
+والـ affected proto-oncogene، affected الـ PCR
+
+793
+01:09:29,670 --> 01:09:33,150
+ABL1 اللي هو الفلادلفيا كروموزوم، وموجود في أكثر
+
+794
+01:09:33,150 --> 01:09:40,730
+منها، اللي بدّي أيّاكم تتذكّروا منه هو تبع الـ CML هذا
+
+795
+01:09:40,730 --> 01:09:50,000
+موجود 95% من الـ «CML»، وبيكون بالشكل اللي حكيناه
+
+796
+01:09:50,000 --> 01:09:53,300
+طبعاً يعني كمان النقطة الثانية اللي واحد ينتبه
+
+797
+01:09:53,300 --> 01:09:59,600
+إليها، لما هم يرسموا لكم إياها هنا، إنّه «Which test I
+
+798
+01:09:59,600 --> 01:10:04,300
+should use to diagnose this translocation»
+
+799
+01:10:04,300 --> 01:10:07,500
+«translocation» يعني قطعة كبيرة، أحنا ما بنتكلّم عن
+
+800
+01:10:07,500 --> 01:10:11,530
+الـ mutation زي single nucleotide polymorphism، الـ
+
+801
+01:10:11,530 --> 01:10:15,050
+«SNP» أو الـ «microsatellite» أو الأشياء الصغيرة
+
+802
+01:10:15,050 --> 01:10:19,790
+هذه قطعة، شُنقة كويسة، كبيرة، فبالتالي أنا لازم أعمل
+
+803
+01:10:19,790 --> 01:10:24,510
+«Karyotype»، هنا بنعمل الـ «Chromosome
+
+804
+01:10:24,510 --> 01:10:29,230
+Translocation»، نعملها Translocation حتّى نفحصها
+
+805
+01:10:29,230 --> 01:10:33,890
+نفحصها من خلال الـ «Karyotype»، وبلّغي هذه الأنواع
+
+806
+01:10:33,890 --> 01:10:39,030
+نتذكّر الـ «CML» والفلادلفيا Chromosome اللي
+
+807
+01:10:39,030 --> 01:10:48,530
+بيصير عندي Translocation بين كروموزوم 9 و22، بالـ9،
+
+808
+01:10:48,530 --> 01:10:55,790
+الـQ هو 34، وبالـ22، الـQ هو 11، الـSegment بتبعات
+
+809
+01:10:55,790 --> 01:11:02,030
+الـDNA أو بتبعات الكروموزوم، حتّى يصير هذه المشكلة
+
+810
+01:11:02,030 --> 01:11:10,290
+واكتشفنا بعدين إنّ الـPCR-ABL-1 Joining هو اللي له
+
+811
+01:11:10,290 --> 01:11:16,980
+مشكلة، وعامل المشكلة، باقي الأشياء ما حصلوا، آخر
+
+812
+01:11:16,980 --> 01:11:30,440
+سلايدين يعني، بتكلّم عن أو آخر موضوعين بدنا
+
+813
+01:11:30,440 --> 01:11:37,880
+نحاول نفهم كيف باكتشف أنّ جين هو اللي عمل المشكلة
+
+814
+01:11:37,880 --> 01:11:47,210
+الموضوع هذا بيكون من خلال دراسة عدد كبير من الجينات
+
+815
+01:11:47,210 --> 01:11:54,830
+والدراسة ممكن يكون لها أكثر من طريقة، الـSNP
+
+816
+01:11:54,830 --> 01:12:01,190
+والـSequencing، بالـPCR وغيره، بيكون من خلال
+
+817
+01:12:01,190 --> 01:12:07,670
+Sequencing وأقرأ الـNucleotides وأحاول أشوف
+
+818
+01:12:07,670 --> 01:12:12,580
+الـVariation فيها، أحياناً في الطريقة الثانية حتّى
+
+819
+01:12:12,580 --> 01:12:21,080
+أستنتج إنّ صار في خلل الجين، إنّ أشوف أنّ جينات صار
+
+820
+01:12:21,080 --> 01:12:24,660
+إلها activation أكثر، وإنّ جينات صار إلها
+
+821
+01:12:24,660 --> 01:12:29,220
+activation أقل، يعني أنا بدرسها بطريقة مختلفة، أنا
+
+822
+01:12:29,220 --> 01:12:35,600
+هنا ما بدرس نفس تركيب الـCoding Gene وشو فيه
+
+823
+01:12:35,600 --> 01:12:40,710
+مشكلة، أنا بحاول أدرس كم هذا الـ gene اشتغل وكم
+
+824
+01:12:40,710 --> 01:12:48,270
+النسخ تبعته، فالـ الـ الـ الـ حتّى ينجح بهذا الأمر
+
+825
+01:12:48,270 --> 01:12:55,990
+أول شيء لازم يكون عندي good sample from، يعني
+
+826
+01:12:55,990 --> 01:13:01,950
+controls and affected people، يعني في الغالب هذه
+
+827
+01:13:01,950 --> 01:13:06,590
+الشيء بقدر أعمله على عائلة، عندي مجموعة أفراد فيها
+
+828
+01:13:07,040 --> 01:13:11,020
+زي مثلًا حكينا ثُمنياً للـ Retinoplastoma أو لا شيء
+
+829
+01:13:11,020 --> 01:13:16,300
+أو أنا أجيب مجموعة مصابين بسرطان معيّن، مثلًا
+
+830
+01:13:16,300 --> 01:13:20,940
+Thyroid Cancer أو CML أو أي نوع Cancer وأجيب
+
+831
+01:13:20,940 --> 01:13:25,180
+مجموعة مصابين وأكون أنا عارف الـStandard
+
+832
+01:13:27,610 --> 01:13:35,170
+شو اسمه؟ عارف الـ Standard Result تبع الأشخاص
+
+833
+01:13:35,170 --> 01:13:40,230
+العاديين، مجموعة أخرى طبيعية مش مصابة، طريقة
+
+834
+01:13:40,230 --> 01:13:45,610
+الدراسة هنا اللي بيسمّوها Expression Profiling، يعني
+
+835
+01:13:45,610 --> 01:13:52,810
+بالأخير أنا بقيس كم نسخة الـ RNA على مستوى الـ RNA
+
+836
+01:13:52,810 --> 01:14:00,830
+أحياناً أو مستوى البروتين، كده اندي بروتين ناتج في
+
+837
+01:14:00,830 --> 01:14:08,770
+هذه الخلايا تبع هذه المجموعة وهذه المجموعة، طريقة
+
+838
+01:14:08,770 --> 01:14:17,350
+القراءة، فإنتَ هنا الجهاز هذا، الدراسة هذه في هذه
+
+839
+01:14:17,350 --> 01:14:22,710
+الـStudies Specifically، درسوا عن حوالي 100 جين
+
+840
+01:14:23,590 --> 01:14:31,970
+طبعاً هذه الصفات اللي يعني نعتبرها الـ «جديدة
+
+841
+01:14:31,970 --> 01:14:38,290
+التكنولوجيا» لتعمل الدراسات اللي هي إنّه أنا عند
+
+842
+01:14:38,290 --> 01:14:42,070
+الآلة قوية جداً زي كمبيوتر سريع جداً زي جوجل هيك،
+
+843
+01:14:42,070 --> 01:14:47,770
+بتحطّ له كلمتين بتجيب لك البحث خلال واحد بالمئة من
+
+844
+01:14:4
+
+889
+01:18:43,570 --> 01:18:43,590
+مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب
+
+890
+01:18:43,590 --> 01:18:43,750
+مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب
+
+891
+01:18:43,750 --> 01:18:44,010
+مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب
+
+892
+01:18:44,010 --> 01:18:44,770
+مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب
+
+893
+01:18:58,620 --> 01:19:03,060
+واللي مثلًا كله أصفر بالباقية معناته لأ ما كان له
+
+894
+01:19:03,060 --> 01:19:08,260
+دخله ما له كان له دور يعني هاي الأشياء بتكون
+
+895
+01:19:08,260 --> 01:19:16,280
+بأذا الشكل هنا بنفس الطريقة يعني هاي على نفس
+
+896
+01:19:16,280 --> 01:19:21,740
+المبدأ اللي شفناها قبل شوية
+
+897
+01:19:29,310 --> 01:19:35,570
+هذه الأنواع من الدراسات صراحةً يعني معقدة جدًا
+
+898
+01:19:35,570 --> 01:19:40,990
+وللأسف يعني أحيانًا كثيرة حتى لو بحاول أقراها في
+
+899
+01:19:40,990 --> 01:19:46,150
+مجلات علمية وبحاول أرجع إلى الـ Original Data مرات
+
+900
+01:19:46,150 --> 01:19:51,110
+كثير بتكون غير مفهومة بشكل قوي وبالتالي يعني
+
+901
+01:19:51,110 --> 01:19:58,250
+بتخربط الواحد اللي بده يحكي هنا أنه حتى يثبتوا
+
+902
+01:19:58,250 --> 01:20:06,490
+أنه والله الجين الفلاني هو المهم وهو اللي يعني
+
+903
+01:20:06,490 --> 01:20:09,690
+اللي
+
+904
+01:20:09,690 --> 01:20:18,890
+له دور أكبر أحيانًا من يعني طريقة المتابعة للمرضى
+
+905
+01:20:21,460 --> 01:20:24,820
+أنه أنا أربط الموضوع هذا بالنسبة للـ Gene
+
+906
+01:20:24,820 --> 01:20:32,140
+Expression مع الـ Survivor يعني أنا عندي الآن مثلًا
+
+907
+01:20:32,140 --> 01:20:38,720
+مئة مريض lung cancer نفترض هيك وأخذت بالـ Diagnosis
+
+908
+01:20:38,720 --> 01:20:44,820
+lung cancer وجئت بعدين عملت نوع من الدراسة زي هذه
+
+909
+01:20:45,490 --> 01:20:51,670
+وبحاول أشوف أقدر بطريقة معينة أن أخليهم cluster
+
+910
+01:20:51,670 --> 01:21:00,850
+يعني يكونوا مجموعة يعني ممكن نوعية معينة مثلًا شيء
+
+911
+01:21:00,850 --> 01:21:05,070
+مميز له أهمية
+
+912
+01:21:05,070 --> 01:21:10,310
+الـ Gene بالذات على الـ pathogenesis على الـ
+
+913
+01:21:10,310 --> 01:21:15,390
+Prognosis على إذا أحيانًا Treatment Modality أنه
+
+914
+01:21:15,390 --> 01:21:20,490
+أنا يعني هنا نوع دراسي آخر مختلف أنه بعد ما عرفت
+
+915
+01:21:20,490 --> 01:21:25,690
+أنه أنا قسمت الخلايا أو قسمت الـ Sample أنه هؤلاء
+
+916
+01:21:25,690 --> 01:21:30,210
+مجموعة عندهم certain genes هم اللي مش شغالين و
+
+917
+01:21:30,210 --> 01:21:33,070
+certain genes هم الشغالين على العكس الـ Cluster B
+
+918
+01:21:33,820 --> 01:21:40,060
+بلاقي أنه بعدين تابعت المرضى هؤلاء وخصوصًا هنا
+
+919
+01:21:40,060 --> 01:21:43,140
+الحالة بقاعي بالـ months على كلامهم يعني هنا
+
+920
+01:21:43,140 --> 01:21:47,360
+تابعوا المرضى عشر سنين زي الـ CML أو الـ prostate
+
+921
+01:21:47,360 --> 01:21:51,960
+cancer هذولة cancer ولو أنهم cancer بس بطيء وبعض
+
+922
+01:21:51,960 --> 01:21:56,100
+أنواع السرطانات هكذا فنتج عن الأمر هذا أنه أنا
+
+923
+01:21:56,100 --> 01:22:01,400
+لاحظت أن اللي عندهم بهذا الشكل لأ والله شغلهم أحسن
+
+924
+01:22:01,400 --> 01:22:05,580
+يعني أنا هنا ما بكون aggressive ما بكون هذا هذا
+
+925
+01:22:05,580 --> 01:22:10,440
+المريض بروستات كانسر والله مرات كثيرة بحكي وبقول
+
+926
+01:22:10,440 --> 01:22:14,580
+للأهل المرضى هو مرضى إذا ذات كبير بالعمر وعنده
+
+927
+01:22:14,580 --> 01:22:19,860
+نوعية بطيئة بقوله يمكن لو علاجناه نذبحه أسرع نقتل
+
+928
+01:22:19,860 --> 01:22:27,340
+المريض أسرع من أن نتركه لحاله هنا يثبتوا أنها
+
+929
+01:22:27,340 --> 01:22:34,340
+Two clusters by the gene expression واستفدت منها
+
+930
+01:22:34,340 --> 01:22:38,480
+أن اللي عنده الـ Cluster A لازم يكون Aggressive
+
+931
+01:22:38,480 --> 01:22:42,740
+لأن هذا الإنسان راح يكون الـ Prognosis تبعه Bad،
+
+932
+01:22:42,740 --> 01:22:46,460
+Poor، على العكس لو كان على الـ Cluster B وهي فائدة
+
+933
+01:22:46,460 --> 01:22:49,960
+لهذا النوع من الدراسات الـ Long Term Survival
+
+934
+01:22:49,960 --> 01:22:57,730
+النقطة الأخيرة أنه يعني حتى في مفهوم قضية أن كل
+
+935
+01:22:57,730 --> 01:23:01,510
+خلية لازم يكون لها كل نوع من الخلايا لازم يكون لها
+
+936
+01:23:01,510 --> 01:23:05,430
+نوع معين من الـ Transcription Factor من Certain
+
+937
+01:23:05,430 --> 01:23:12,370
+Signals Signal Transduction فهذه أنتجت أنه صار
+
+938
+01:23:12,370 --> 01:23:17,210
+عندي أنواع كثيرة من الأدوية اللي بتحاول تخرّب أو
+
+939
+01:23:17,210 --> 01:23:25,940
+تنشط مرات Certain Signal Transduction فهذه يعني
+
+940
+01:23:25,940 --> 01:23:30,140
+نسميهم «Tyrosine Kinase Inhibitor» أحيانًا
+
+941
+01:23:30,140 --> 01:23:36,620
+«Activator» بس يعني «Tyrosine Kinase» يعني
+
+942
+01:23:36,620 --> 01:23:46,120
+«Inhibitor» أو أحيانًا «Modifier» أو هكذا ففيه
+
+943
+01:23:46,120 --> 01:23:49,580
+الآن طالع عندي مجموعة «Cancer Treatments Targeted
+
+944
+01:23:49,580 --> 01:23:53,140
+to Specific Activated Driver Oncogenes»
+
+945
+01:23:56,310 --> 01:24:04,410
+الأدوية أسماؤها كثيرة فإحنا بدي منكم اثنين الـ
+
+946
+01:24:04,410 --> 01:24:14,350
+Imatinib اللي هو نسيت اسمه نسيت Imatinib في ليس
+
+947
+01:24:14,350 --> 01:24:21,870
+تجاري مشهور جدًا بس راح أتكلم هذا عبارة عن يعني
+
+948
+01:24:21,870 --> 01:24:27,350
+بالذات للـ CML يعني قريب بدخل في زي ما حكينا
+
+949
+01:24:27,350 --> 01:24:35,850
+الـ Philadelphia chromosome هذا عبارة عن يعني drug very
+
+950
+01:24:35,850 --> 01:24:43,850
+specific to the myeloid series ونتيجته أنه كأنه
+
+951
+01:24:43,850 --> 01:24:49,170
+الـ Apoptosis تبع الخلايا بوقّت الـ CML هو بتجبر
+
+952
+01:24:49,170 --> 01:24:54,570
+الخلايا تظل تنقسم وتكمل هو Specific Inhibitor of
+
+953
+01:24:54,570 --> 01:25:00,550
+Tyrosine Kinase الـ NIP إذا بتنتبهوا عليها بالأخير
+
+954
+01:25:00,550 --> 01:25:07,710
+هاي اللي هما الأسماء تبعات الـ Inhibitors of
+
+955
+01:25:07,710 --> 01:25:13,530
+Tyrosine Kinase الـ NIPS دولة فـ Gifety-NIP، Matty
+
+956
+01:25:13,530 --> 01:25:17,810
+-NIP، Milton-NIP ومش عارف دستاني-NIP هذول إذا
+
+957
+01:25:17,810 --> 01:25:22,250
+بتشوفوا شيء زي هيك اسمه بالأخير هذا Inhibitor of a
+
+958
+01:25:22,250 --> 01:25:26,970
+Certain Tyrosine Kinase وبصير يعني نتيجة بدأ الأمر
+
+959
+01:25:26,970 --> 01:25:30,950
+أنه أنا أول شيء درست الـ Gene ودرست الـ… هو
+
+960
+01:25:30,950 --> 01:25:34,890
+الـ Oncogene أو Driver Oncogene وشفت الـ Signal
+
+961
+01:25:34,890 --> 01:25:39,450
+Transduction تبعه أنه Tyrosine Kinase صرت أجيب أدوية
+
+962
+01:25:39,450 --> 01:25:43,030
+ومركبات وأشياء أشوف مين اللي بيطبطب هذا الـ Tyrosine
+
+963
+01:25:43,030 --> 01:25:48,660
+Kinase وطلعوا مجموعة أدوية كبيرة فهذه الآن يعني هي
+
+964
+01:25:48,660 --> 01:25:54,040
+دراسة Targeted وهذه كلها من شركات أجرت دراسات
+
+965
+01:25:54,040 --> 01:25:59,640
+على السرطانات بهذا الشكل بتأخذ السرطان، بتعزل الـ
+
+966
+01:25:59,640 --> 01:26:04,360
+Tyrosinkinase تبعه بتحاول أن تتألف دواء ضد الـ
+
+967
+01:26:04,360 --> 01:26:09,380
+Tyrosinkinase فهذه مجموعة أدوية في أشياء كثيرة
+
+968
+01:26:09,380 --> 01:26:15,970
+أنا بس أطلب منكم الـ Imatinib اللي هو بالـ CML لأنه
+
+969
+01:26:15,970 --> 01:26:20,210
+فعّال جدًا وكويس والـ side effects تبعه قليل يعني
+
+970
+01:26:20,210 --> 01:26:24,070
+له major side effects بس نسبيًا مش زي الكيموتراب
+
+971
+01:26:24,070 --> 01:26:28,290
+التاني والـ… والـ… يعني والـ much better
+
+972
+01:26:28,290 --> 01:26:35,270
+tolerated أحسن من الجروب الثانية اللي هي بالأخير MAP
+
+973
+01:26:35,270 --> 01:26:42,830
+مثلًا Herceptin وغيرها اللي هو Trastuzumab اللي هو
+
+974
+01:26:42,830 --> 01:26:50,150
+Amplified HER2-Gene في الـ Breast Cancer فالـ
+
+975
+01:26:50,150 --> 01:26:53,450
+Breast Cancer الآن إحنا عندنا حتى في مستشفى الملك
+
+976
+01:26:53,450 --> 01:26:58,390
+المؤسس أي امرأة أو إنسان حتى ما يمكن نصيب الذكور
+
+977
+01:26:58,390 --> 01:27:04,390
+الـ Breast Cancer إذا في حالة عندي HER2-Receptor
+
+978
+01:27:04,390 --> 01:27:09,630
+Positive نعطيه هذا الدواء، طبعًا مشكلته الأنبوبة
+
+979
+01:27:09,630 --> 01:27:13,620
+الواحدة يبدو المريض مثلًا في كل جرعة، أنبوبتين،
+
+980
+01:27:13,620 --> 01:27:19,380
+ثلاث، أربع أحيانًا بالألوف يعني all these drugs
+
+981
+01:27:19,380 --> 01:27:24,380
+are very extensive، very recent وفي شغل كثير عليهم
+
+982
+01:27:24,380 --> 01:27:30,000
+الـ MABs اللي هم الـ Monoclonal Antibody ناشي، وله
+
+983
+01:27:30,000 --> 01:27:33,920
+أنواعه المفروض تكونوا تعرفوا عنه من الـ Immunology
+
+984
+01:27:33,920 --> 01:27:37,540
+في أحد عنده أسئلة؟ أي آخر slide؟
+
+985
+01:27:42,970 --> 01:27:47,890
+الله يعطيكم العافية وإن شاء الله إذا في أسئلة
+
+986
+01:27:47,890 --> 01:27:52,750
+للأسبوع القادم وبنكمل إن شاء الله الله يعطيكم
+
+987
+01:27:52,750 --> 01:27:57,370
+العافية ويرزقكم الخير ونشوفكم الأسبوع اللي جاي
+
+988
+01:27:57,370 --> 01:28:01,390
+يعطيك ألف عافية دكتور الله يرضى عليك الله حييك
+
+989
+01:28:01,390 --> 01:28:03,950
+الله يكرمك سلام عليك برعاية الله
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/J6cZgtP3lRU_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/J6cZgtP3lRU_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..5d6a2cd0ef25b7f31cc0ca1e4061d6092af0a741
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/J6cZgtP3lRU_raw.srt
@@ -0,0 +1,4016 @@
+1
+00:00:00,000 --> 00:00:08,060
+أربعة ‏so far ‏طيب احنا المحاضرة بتتسجل ‏وإن شاء
+
+2
+00:00:08,060 --> 00:00:13,520
+الله يعني بالنسبة
+
+3
+00:00:13,520 --> 00:00:21,540
+لكم نبدأ ‏وبالنسبة لزي ما حكينا كل مرة ‏أول شيء ده
+
+4
+00:00:21,540 --> 00:00:28,220
+حد عنده أي أسئلة يعنيمراجعات كيف صلّح الكمبيوتر
+
+5
+00:00:28,220 --> 00:00:31,440
+وإن أنا غلطت وإن كان قصدي هيك أو مش قصدي هيك، فما
+
+6
+00:00:31,440 --> 00:00:38,880
+تتراجعي، فبتجننوك الطلاب وبرضوش وبتضيع الوقت أحنا
+
+7
+00:00:38,880 --> 00:00:44,000
+المهم أن الواحد يستفيد ويكون يعني حتى بالنسبة
+
+8
+00:00:44,000 --> 00:00:49,220
+للسؤال فاهم ليش هي صح ليش هي غلط المهم الفهم، بغض
+
+9
+00:00:49,220 --> 00:00:53,200
+النظر عن العلامة يعني العلامة مش مهم كتير، الله
+
+10
+00:00:53,200 --> 00:01:01,100
+أعينفي أسئلة يا دكتور أحمد؟ لأ، بخصوص المادة لا
+
+11
+00:01:01,100 --> 00:01:09,000
+لسه طيب إن شاء الله اليوم راح نتكلم عن موضوع
+
+12
+00:01:09,000 --> 00:01:14,200
+السرطانات أو الـ Cancer Genetics وGenomics بصراحة
+
+13
+00:01:14,200 --> 00:01:21,140
+يعني فيه ثلاث سلايدات مهمات جداً عشان يعني تبين
+
+14
+00:01:21,140 --> 00:01:22,720
+مفاهيم معينة
+
+15
+00:01:27,780 --> 00:01:33,160
+والدراسة أو يعني محاولة الدراسة هتكون على نوعين
+
+16
+00:01:33,160 --> 00:01:37,360
+اللي هم الـ Genetics والـ Genomics يعني لنشوف شو
+
+17
+00:01:37,360 --> 00:01:41,900
+دور هاي وهاي وكيف نشتغل فيها وشو اللي بيكون موجود
+
+18
+00:01:41,900 --> 00:01:50,100
+الـ Cancer اللي هي الأورام أو الورم يعني is a big
+
+19
+00:01:50,100 --> 00:01:56,280
+concept مفهوم كبير في الطبوحالات كثيرة ومن أهم
+
+20
+00:01:56,280 --> 00:02:03,120
+الأمراض اللي بتسبب وفيات ومن أهم الأمراض اللي يعني
+
+21
+00:02:03,120 --> 00:02:09,880
+بتتم دراستها وفي صعوبة في معالجتها والميزة
+
+22
+00:02:09,880 --> 00:02:16,100
+الأساسية فيها أن التسبب فيها معقد جداًوإن المناعة
+
+23
+00:02:16,100 --> 00:02:19,720
+اللي أنا من نفس خلايا الجسم ما بتقدر تقاومها يعني
+
+24
+00:02:19,720 --> 00:02:23,560
+it is highly complex in etiology الـ etiology
+
+25
+00:02:23,560 --> 00:02:29,160
+تبعتها تسبب فيها عادة multifactorial with so many
+
+26
+00:02:29,160 --> 00:02:34,420
+other components وأكثر من خلل معين بيصير بس واضح
+
+27
+00:02:34,420 --> 00:02:38,060
+إن الجينات والوراثة اللي دخل فيها والمناعة اللي
+
+28
+00:02:38,060 --> 00:02:47,050
+دخل فيها وفيه يعني مفاهيم كثيرةالورم هي يعني اللي
+
+29
+00:02:47,050 --> 00:02:50,910
+هي الـ Abnormal cells is like a mass يعني بالأخير
+
+30
+00:02:50,910 --> 00:02:56,590
+ورم يعني كتلة هيكي فحتى تصير كتلة يعني الواحد لازم
+
+31
+00:02:56,590 --> 00:03:01,730
+يتذكر إنه راح يكون في الغالب نمو غير طبيعي يعني
+
+32
+00:03:01,730 --> 00:03:09,020
+خلايا تتكاثر بشكل غير طبيعي زيادة عن اللزومفهذا قد
+
+33
+00:03:09,020 --> 00:03:13,700
+يكون إيتيولوجيا ويكون سبب بس كمان في أحيانا بتكون
+
+34
+00:03:13,700 --> 00:03:18,160
+إن الخلايا بتموتش بالشكل السريع يعني زي ما ممكن
+
+35
+00:03:18,160 --> 00:03:22,700
+تكون increased cell division as a cause of the
+
+36
+00:03:22,700 --> 00:03:31,180
+tumor formation ممكن decreased apoptosisبالعكس من
+
+37
+00:03:31,180 --> 00:03:35,600
+الجهة التانية بيكون أحيانًا هو السبب يعني بس
+
+38
+00:03:35,600 --> 00:03:41,880
+بالأخير يعني بنعتبر abnormal cell cycle الـ
+
+39
+00:03:41,880 --> 00:03:47,680
+cancers اللي هم two other major behavior problems
+
+40
+00:03:47,680 --> 00:03:56,560
+الخلايا الطبيعية لما تشوف خلية مش شابهة لها يعني
+
+41
+00:03:56,560 --> 00:03:59,960
+لو جبت بتري دش وحطيت شوية خلايا
+
+42
+00:04:11,660 --> 00:04:17,440
+الخلايا اللي من نفس النوع لما انتصل جنب بعض بتوقف
+
+43
+00:04:17,440 --> 00:04:21,140
+و الـ cell membrane تبعها بيبطل يتحرك و هذا بيسموه
+
+44
+00:04:21,140 --> 00:04:25,140
+contact inhibition فالـ cancer cells they don't
+
+45
+00:04:25,140 --> 00:04:32,470
+have contact inhibition they keep movingيعني
+
+46
+00:04:32,470 --> 00:04:38,490
+الوصول إلى موقع مستقبل المعانات يعني كثير من
+
+47
+00:04:38,490 --> 00:04:42,810
+الخلايا الثانية اللي بتكون محترمة هيكي و بس تصل
+
+48
+00:04:42,810 --> 00:04:46,030
+مكان معين بتوقف عنده، ما عدا الخلايا السرطانية
+
+49
+00:04:46,030 --> 00:04:50,110
+الخلايا السرطانية، هم يفقدون انهيبشتهم بالتواصل
+
+50
+00:04:50,110 --> 00:04:56,350
+وهم لديهم تندنسية لـMetastasis لـMetastasize نتيجة
+
+51
+00:04:56,350 --> 00:05:01,320
+الانتشار هذا، بتلاقيها بتروح لماكن بعيدةفالـ
+
+52
+00:05:01,320 --> 00:05:06,320
+«سلايد» الأول اللي حاطيه لكم إياه بيبين فيها كيف
+
+53
+00:05:06,320 --> 00:05:11,660
+مراحل النشوء
+
+54
+00:05:11,660 --> 00:05:16,540
+وحدوث مشكلة السرطان طبعاً المشكلة حتى لو ظهرت في
+
+55
+00:05:16,540 --> 00:05:20,860
+لحظة معينة عند إنسان بتكون صالة زمان وهي ماشية
+
+56
+00:05:20,860 --> 00:05:27,220
+وبتتكون وبتمر بـ stages كتير قبل حتى ما نشوفهاهذه
+
+57
+00:05:27,220 --> 00:05:30,900
+مثلًا الـ Normal Epithelium سواء بالـ GI Tract أو
+
+58
+00:05:30,900 --> 00:05:36,900
+في أي محل نجد أن هناك الـ Normal Epithelium اللي
+
+59
+00:05:36,900 --> 00:05:41,160
+موجود والـ Sub-epithelial areas اللي من الـ
+
+60
+00:05:41,160 --> 00:05:45,120
+Appropriate ويكون مثلًا فيه Lymphatic vessels
+
+61
+00:05:45,120 --> 00:05:50,300
+وBlood vessels والأشياء عادية هناالمشكلة الحرارية
+
+62
+00:05:50,300 --> 00:05:55,760
+تبدأ بـExcessive proliferation of abnormal cells
+
+63
+00:05:55,760 --> 00:06:00,940
+بيبدأ في المنطقة الميكوزالية وبتكون في الـ Stage
+
+64
+00:06:00,940 --> 00:06:06,480
+الأولى بهذا الشكل لأنهم فقدوا انهياب الاتصال
+
+65
+00:06:06,480 --> 00:06:15,410
+وبدأوا بالـMetastasizeتتخرج من
+
+66
+00:06:15,410 --> 00:06:19,770
+محيطها، تتخرج من مكانها، تتدخل إلى الـsub-mucosal
+
+67
+00:06:19,770 --> 00:06:23,350
+area يعني احنا كثير مثلا في أشياء في الجلد أو في
+
+68
+00:06:23,350 --> 00:06:27,650
+الـGI tract لوين خازقة ولوين واصلة، هذا إشي مهم
+
+69
+00:06:27,650 --> 00:06:31,830
+للـstage وشو اللي نحتاج نعمله للـtreatment
+
+70
+00:06:31,830 --> 00:06:36,590
+والـmanagement ولكذافتبدأ بتخرق بالـ Surrounding
+
+71
+00:06:36,590 --> 00:06:41,200
+Tissues، وبعدين They Extend Into Localالـ lymph
+
+72
+00:06:41,200 --> 00:06:46,700
+nodes وبعدين بيصير إذا بينتشر بالدم بيصير يقدر
+
+73
+00:06:46,700 --> 00:06:49,760
+يروح على distant metastases مثل الـ liver، الـ
+
+74
+00:06:49,760 --> 00:06:53,360
+kidneys، الـ lungs يعني الـ lungs number one لأن
+
+75
+00:06:53,360 --> 00:06:57,640
+كل الـ circulation بالأخير لازم تمر بالـ lungs at
+
+76
+00:06:57,640 --> 00:07:01,880
+some stage to oxygenate the hemoglobin فالـ lung
+
+77
+00:07:01,880 --> 00:07:05,940
+metastases، الـ liver، but any other organ they
+
+78
+00:07:05,940 --> 00:07:12,390
+can have metastasesهذه مرحلة عادية
+
+79
+00:07:12,390 --> 00:07:15,430
+في
+
+80
+00:07:15,430 --> 00:07:22,490
+الـ «تيومر»
+
+81
+00:07:22,490 --> 00:07:27,810
+أو الـ «كانسيروم» أو الـ «تيولوجيا» أو الـ
+
+82
+00:07:27,810 --> 00:07:33,350
+«جينيسيا» أو الـ «تيومر»الـ Stage الأولى يعني مرات
+
+83
+00:07:33,350 --> 00:07:39,730
+ممكن يسموها «Carcinoma in Situ» يعني لسه محصورة
+
+84
+00:07:39,730 --> 00:07:46,590
+ومش منتشرة وبعدين «Local Invasion» وبعدين «Frank
+
+85
+00:07:46,590 --> 00:07:50,250
+Invasion» و«Reaching the Regional Lymph Nodes»
+
+86
+00:07:50,250 --> 00:07:53,870
+وبعدين بيصير «Distant Metastasis» وهنا بيكون
+
+87
+00:07:53,870 --> 00:07:59,710
+الأمور يعني تقريبًا في الغالب انتهت يعنيالحالة
+
+88
+00:07:59,710 --> 00:08:10,390
+متقدمة والوضع سيء لما نأتي نشوف هذا الموضوع الآن
+
+89
+00:08:10,390 --> 00:08:13,290
+ستكون عملية عملية عملية عملية عملية عملية عملية
+
+90
+00:08:13,290 --> 00:08:14,050
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+91
+00:08:14,050 --> 00:08:17,450
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+92
+00:08:17,450 --> 00:08:17,470
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+93
+00:08:17,470 --> 00:08:17,470
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+94
+00:08:17,470 --> 00:08:17,470
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+95
+00:08:17,470 --> 00:08:17,470
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+96
+00:08:17,470 --> 00:08:17,730
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+97
+00:08:17,730 --> 00:08:19,150
+عملية
+
+98
+00:08:29,880 --> 00:08:40,360
+في النهاية، يعني فيه table أو فيه paragraph في box
+
+99
+00:08:40,360 --> 00:08:51,100
+حاطين فيه الـ biggest points بالنسبة
+
+100
+00:08:51,100 --> 00:08:58,920
+للـ cancer، their behavior is differentسيل سايكلهم
+
+101
+00:08:58,920 --> 00:09:06,820
+مختلفة إنهم يكتشفوا بروتينات جديدة ما نسميه مرات
+
+102
+00:09:06,820 --> 00:09:12,900
+تمور أنتيجين بيكونوا بروتينات جديدة أو شيء مختلف
+
+103
+00:09:12,900 --> 00:09:21,380
+فالـ tumor أو الـ driver genes
+
+104
+00:09:25,240 --> 00:09:29,640
+يعني وين الواحد إذا بده يروح يدور أو شوهي أنواع
+
+105
+00:09:29,640 --> 00:09:34,280
+الجينات اللي بتكون mutated in cancer بالاخر واحد
+
+106
+00:09:34,280 --> 00:09:41,360
+إنه it's mainly really about cell
+
+107
+00:09:41,360 --> 00:09:43,160
+cycle regulation
+
+108
+00:09:45,670 --> 00:09:48,310
+الـ….الـ….الـ…… الـ…… الـ…… الـ…… الـ…… الـ……
+
+109
+00:09:48,310 --> 00:09:48,730
+الـ…… الـ…… الـ…… الـ…… الـ…… الـ…… الـ…… الـ……
+
+110
+00:09:48,730 --> 00:09:49,370
+الـ…… الـ…… الـ…… الـ…… الـ…… الـ…… الـ…… الـ……
+
+111
+00:09:49,370 --> 00:09:54,030
+الـ…… الـ…… الـ…… الـ…… الـ…… الـ…… الـ…… الـ……
+
+112
+00:09:54,030 --> 00:10:06,730
+الـ…… الـ…… الـ…… الـ…… الـ……
+
+113
+00:10:06,730 --> 00:10:09,310
+الـ…
+
+114
+00:10:11,820 --> 00:10:19,880
+الخلية تبدأ تدخل الـ Cell Cycle
+
+115
+00:10:19,880 --> 00:10:23,280
+أو الـ Apoptosis تبدأ تدخل الـ Cell Cycle أو الـ
+
+116
+00:10:23,280 --> 00:10:23,280
+Apoptosis
+
+117
+00:10:27,210 --> 00:10:34,010
+الـG1 والـG2 والـS-Phase والـM والكذا كلهم بيكونوا
+
+118
+00:10:34,010 --> 00:10:37,990
+بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا
+
+119
+00:10:37,990 --> 00:10:38,850
+بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا
+
+120
+00:10:38,850 --> 00:10:38,930
+بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا
+
+121
+00:10:38,930 --> 00:10:38,990
+بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا
+
+122
+00:10:38,990 --> 00:10:39,050
+بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا
+
+123
+00:10:39,050 --> 00:10:39,050
+بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا
+
+124
+00:10:39,050 --> 00:10:39,050
+بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا
+
+125
+00:10:39,050 --> 00:10:39,050
+بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا
+
+126
+00:10:39,050 --> 00:10:56,470
+بيكونوا بي
+
+127
+00:11:02,000 --> 00:11:06,260
+بالنسبة للـ Cell Cycle وفيه Cell Proliferation
+
+128
+00:11:07,560 --> 00:11:12,500
+لانقسام الخلايا أو تكاثر الخلايا فيه لـSignal معين
+
+129
+00:11:12,500 --> 00:11:17,600
+إذا صار فيها mutation هنا ويكون فيها نوع من
+
+130
+00:11:17,600 --> 00:11:21,600
+الـSpecific effect on cellular proliferation فإذا
+
+131
+00:11:21,600 --> 00:11:26,880
+فيه Transcription factors إشي بيخلي certain gene
+
+132
+00:11:26,880 --> 00:11:33,220
+become transcribedممكن الـ Receptors for الـ
+
+133
+00:11:33,220 --> 00:11:36,900
+Transcription Factors اللي هم الـ Main Group هم
+
+134
+00:11:36,900 --> 00:11:40,160
+الـ Tyrosine Kinases الـ Tyrosine هو الـ Amino
+
+135
+00:11:40,160 --> 00:11:43,880
+Acid والـ Kinase هو اللي بيحط الفسفات على الـ
+
+136
+00:11:43,880 --> 00:11:48,440
+Tyrosineأو بيقعوا بيشيلوا منها الفوسفات مرات أخرى
+
+137
+00:11:48,440 --> 00:11:55,680
+فـTyrosine kinase هم مجموعات من طرابات إتصالية
+
+138
+00:11:55,680 --> 00:12:05,240
+لعديد من الهرمونات أو إتصالات من خارج الجسم لتصل
+
+139
+00:12:05,240 --> 00:12:08,410
+إلى الـNucleus ويسبب فيه الأفعالفيه الـ Growth
+
+140
+00:12:08,410 --> 00:12:12,030
+Factors، الـ Changes أو الـ Mutations الـ
+
+141
+00:12:12,030 --> 00:12:15,190
+Intracellular Other Type of كيناز اللي هم الـ
+
+142
+00:12:15,190 --> 00:12:18,590
+Serine، الـ Theriorinine اللي هم أنواع من الـ
+
+143
+00:12:18,590 --> 00:12:25,270
+Amino Acids كينازيز الـ PI-3 كينازيز اللي هم الـ
+
+144
+00:12:25,270 --> 00:12:33,470
+Phosphatidyl-Inostol-3 كيناز يعني إحنا في المناعة
+
+145
+00:12:34,130 --> 00:12:39,390
+في إذا بتنتبهوا أو انتبهتوا عليه فيه إيش اسمه في
+
+146
+00:12:39,390 --> 00:12:43,110
+الـSignal Transduction Topic فيه إيش بيسموه
+
+147
+00:12:43,110 --> 00:12:48,550
+الـJack والستاد الـJack اللي هو يعني إله اسم
+
+148
+00:12:48,550 --> 00:12:54,390
+«Genus Associated Kinase» إله اسم غريب بس بالنسبة
+
+149
+00:12:54,390 --> 00:12:57,910
+ل… يعني أستاد إلي كان يقول لي «Just another
+
+150
+00:12:57,910 --> 00:13:04,140
+kinase» ففي عندنا أنواع كثيرة من الـMoleculesالتي
+
+151
+00:13:04,140 --> 00:13:06,280
+تعمل على عملية عبارة عن عبارة عن عبارة عن عبارة عن
+
+152
+00:13:06,280 --> 00:13:08,840
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+153
+00:13:08,840 --> 00:13:09,980
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+154
+00:13:09,980 --> 00:13:13,680
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+155
+00:13:13,680 --> 00:13:15,920
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+156
+00:13:15,920 --> 00:13:16,700
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+157
+00:13:16,700 --> 00:13:17,480
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+158
+00:13:17,480 --> 00:13:24,520
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+159
+00:13:24,520 --> 00:13:29,510
+عنففيه كمان الـ G-Proteins والـ «G-Protein Coupled
+
+160
+00:13:29,510 --> 00:13:32,290
+Receptors» كمان هدولة اللي مدخل بالـ Signal
+
+161
+00:13:32,290 --> 00:13:38,710
+Transduction فيه هنا «M mammalian target of
+
+162
+00:13:38,710 --> 00:13:46,090
+rapamycin» هدولة الـ Signal Pathway كمان «Winet»
+
+163
+00:13:46,090 --> 00:13:50,510
+«B» «Beta» «Catenin signaling transcription
+
+164
+00:13:50,510 --> 00:13:57,760
+factors»حاطينهم مكررينها مرتين، هذا غلط إملائي أو
+
+165
+00:13:57,760 --> 00:14:01,700
+عدم انتباه من اللي حاطط، بس إن هناك أمثلة كثيرة
+
+166
+00:14:01,700 --> 00:14:07,080
+Differentiation and Lineage Survivalحكينا إحنا
+
+167
+00:14:07,080 --> 00:14:11,280
+هذولة يمكن الـ Jack و الـ Stat و هذولة مشتركات من
+
+168
+00:14:11,280 --> 00:14:16,060
+أكتر من نوع من الخلايا بس لازم يكون لكل نوع خلية
+
+169
+00:14:16,060 --> 00:14:21,040
+فيه specific transcription factor أو regulator for
+
+170
+00:14:21,040 --> 00:14:27,480
+each type of cell وفيه regulators of apoptosis الـ
+
+171
+00:14:27,480 --> 00:14:32,280
+other group of genes اللي هم global effects on the
+
+172
+00:14:32,280 --> 00:14:40,170
+genome and DNA integrity أوGene Expressionالمطلوب
+
+173
+00:14:40,170 --> 00:14:45,490
+أنه الـGenome Integrity اللي فيه DNA Repair
+
+174
+00:14:45,490 --> 00:14:48,550
+الـChromosomal
+
+175
+00:14:48,550 --> 00:14:51,670
+Segregation الـGenome and Gene Mutation Inhibition
+
+176
+00:14:51,670 --> 00:14:56,650
+يعني الـRegulation الـGene Expression with
+
+177
+00:14:56,650 --> 00:15:01,950
+Abnormal Metabolizing Effect يعني التأثيرات على
+
+178
+00:15:01,950 --> 00:15:06,630
+الـGene Expression اللي فيه Certain Epigenetic
+
+179
+00:15:06,630 --> 00:15:11,560
+Mutationفنتكلم عنهم بما فيه الـ «DNA Methylation»
+
+180
+00:15:11,560 --> 00:15:16,460
+أو «Hydroxyl Methylation» و«Histone Methylation»
+
+181
+00:15:16,460 --> 00:15:20,480
+أو «Demethylation» أو «Acetylation» «Nucleosome
+
+182
+00:15:20,480 --> 00:15:26,360
+Remodeling» «Chromatin Accessibility»
+
+183
+00:15:26,360 --> 00:15:30,360
+يعني سهولة الوصول لقطع معينة و«Compaction» لما
+
+184
+00:15:30,360 --> 00:15:34,120
+ينضغطوبالتالي ما يقدرش أي شيء يقرأ منها
+
+185
+00:15:34,120 --> 00:15:37,820
+الـDifferent levels of gene expression with
+
+186
+00:15:37,820 --> 00:15:41,980
+certain post-transcriptional alterations زي
+
+187
+00:15:41,980 --> 00:15:47,580
+التأثيرات على الـApparent RNA والـMicro-RNAs
+
+188
+00:15:47,580 --> 00:15:53,080
+وهدولة يعتبروا كمان من الـEpigenetic Control واللي
+
+189
+00:15:53,080 --> 00:15:56,300
+على الـGene Expression أو الـProtein Stability أو
+
+190
+00:15:56,300 --> 00:15:58,440
+Turnover هدولة
+
+191
+00:16:00,200 --> 00:16:05,640
+أمثلة على الـ «جينات» وأشياء اللي دخلت بالـ
+
+192
+00:16:05,640 --> 00:16:12,100
+«كانسورز» ويعني الحابين
+
+193
+00:16:12,100 --> 00:16:17,040
+هنا يفرقوهم لـ «جينات» بأفعال محددة على الـ
+
+194
+00:16:17,040 --> 00:16:21,400
+Cellular Proliferation أو الـ Apoptosis وعلى الـ
+
+195
+00:16:21,400 --> 00:16:23,860
+«جينوم» أو الـ DNA Integrity أو الـ Gene
+
+196
+00:16:23,860 --> 00:16:28,340
+Expression بالنوع الثاني في حد عنده سؤال؟
+
+197
+00:16:31,930 --> 00:16:35,090
+إذا كان هناك أي سؤال، يا دكتور أحمد، واقفني
+
+198
+00:16:35,090 --> 00:16:39,030
+وأخبرهم أن يسألوا ونرى إذا كان هناك أي شيء غير
+
+199
+00:16:39,030 --> 00:16:45,770
+واضح. الآن، عندما نأتي ونرى
+
+200
+00:16:45,770 --> 00:16:51,250
+كيف الوضع، لكي نرى أي أماكن في الغالب،في
+
+201
+00:16:51,250 --> 00:17:00,670
+الـCancers، أين هي الـAnomalies؟ أين هي التغييرات
+
+202
+00:17:00,670 --> 00:17:04,590
+المحددة؟ وحكينا
+
+203
+00:17:04,590 --> 00:17:09,550
+الملاحظة عن الموضوع هذا كما حكيت بالأول، إنه عادةً
+
+204
+00:17:09,550 --> 00:17:13,940
+كمplex، إنه عادةً أكتر من واحد فاكتورأكيد فيه الـ
+
+205
+00:17:13,940 --> 00:17:19,020
+Environmental Factors كثيرة زي مثلًا الـ
+
+206
+00:17:19,020 --> 00:17:22,860
+Radiation، الـ Chemicals زي الـ Smoking، الـ
+
+207
+00:17:22,860 --> 00:17:29,960
+Asbestos، الـ Drugs، الـ Viral Infections أو الـ
+
+208
+00:17:29,960 --> 00:17:33,360
+Infections in general ممكن يكون إليها دخل ففيها
+
+209
+00:17:33,360 --> 00:17:36,840
+أشياء كثيرة بتتدخل إنه بالأخير بيصير عندي الورم
+
+210
+00:17:36,840 --> 00:17:41,460
+اللي أنا بشوفه وبشوف الخلايا اللي بتشتغل بشكل غير
+
+211
+00:17:41,460 --> 00:17:51,770
+طبيعيالآن إذا شُفت أنا إيش الوضع بالنسبة لـ الـ
+
+212
+00:17:51,770 --> 00:17:58,790
+بالنسبة لو أطلع على إيش بيصير بالنسبة للـ Normal
+
+213
+00:17:58,790 --> 00:18:04,810
+Cell Behavior وكيف تشتغل، فأقول أنا بالأول عندي
+
+214
+00:18:04,810 --> 00:18:09,510
+The Whole Genome والـ Genome هذا Controlled، يعني
+
+215
+00:18:09,510 --> 00:18:13,990
+كل الخلايا لما تنقسمالـ DNA Replication لازم يكون
+
+216
+00:18:13,990 --> 00:18:20,130
+Perfect لازم يكون مية بالمية، مافيش نسبة خطأ وإذا
+
+217
+00:18:20,130 --> 00:18:22,630
+صار خطأ لازم فيه Mechanisms أو There are
+
+218
+00:18:22,630 --> 00:18:27,190
+Mechanisms for Repairوفي ND لازم عشان أعرف أنا
+
+219
+00:18:27,190 --> 00:18:31,570
+أسوي الـ Transcription لازم الـ Chromosome هتكون
+
+220
+00:18:31,570 --> 00:18:36,390
+Stable و able to segregate يعني لما تنقسم الخلية،
+
+221
+00:18:36,390 --> 00:18:41,410
+الانقسام يكون متساوي ونفس الـ Copy of the whole
+
+222
+00:18:41,410 --> 00:18:49,230
+genome is transferred to the daughter cells فلما
+
+223
+00:18:49,230 --> 00:18:54,030
+أنا أجي أعمل Gene Expressionأفتح الـ Transcription
+
+224
+00:18:54,030 --> 00:19:00,070
+و Translation لازم أفتح الـ Two Strands of DNA
+
+225
+00:19:00,070 --> 00:19:07,250
+يعني هو أصلا الـ DNA ملفوف، لف شديد زي طبّة إحبال
+
+226
+00:19:07,250 --> 00:19:13,550
+مربوطة كثير في شكل كرة و اللي بيخلّيه ثابت في هذا
+
+227
+00:19:13,550 --> 00:19:17,210
+الـ EC Structures حكينا هم الـ Histones الـ
+
+228
+00:19:17,210 --> 00:19:22,980
+Histones have to beعلى مجموعة جينات مستخدمة
+
+229
+00:19:22,980 --> 00:19:27,100
+للتواصل مع بعضها لازم الـ Histone في المنطقة اللي
+
+230
+00:19:27,100 --> 00:19:33,480
+فيها الجين المطلوب يتم تغييره بشكل بحيث أنه الـ
+
+231
+00:19:33,480 --> 00:19:37,600
+Chromatin والـ DNA يكون accessible للـ RNA
+
+232
+00:19:37,600 --> 00:19:41,640
+بوليماريز اللي راح من الـ DNA يعني يعمل عملية الـ
+
+233
+00:19:41,640 --> 00:19:46,520
+Transcription للـ DNAويعطيني الـ Gene Expression
+
+234
+00:19:46,520 --> 00:19:51,660
+اللي هو الـ Messenger RNA وبعدين الـ Messenger RNA
+
+235
+00:19:51,660 --> 00:19:57,500
+طبعاً بالأول RNA عادي كامل أو أولي، وبعدين بتصير
+
+236
+00:19:57,500 --> 00:20:05,940
+Splicing وبتكون الـ Messenger RNA المطلوب حتى يصير
+
+237
+00:20:05,940 --> 00:20:11,740
+الـ Gene Protein Expression فهذه هنا، بيصير عندي
+
+238
+00:20:11,740 --> 00:20:15,760
+Variation أنهالـ Copy Number وبكلها بتأثر على الـ
+
+239
+00:20:15,760 --> 00:20:24,360
+Translation و Transcription وبعدين Translation بعد
+
+240
+00:20:24,360 --> 00:20:30,660
+هيك الخلايا هذه بحاجة أن تصير أنها لها Cell Cycle
+
+241
+00:20:30,660 --> 00:20:35,560
+Control وControlled Proliferation يعني إشي قريب من
+
+242
+00:20:35,560 --> 00:20:39,380
+هذا الموضوعيعني الـ Cell Cycle Control يعني اللي
+
+243
+00:20:39,380 --> 00:20:43,660
+هي الـ Checkpoints البروتينز عبارة عن Signal
+
+244
+00:20:43,660 --> 00:20:49,180
+وجزيئات داخل الخلية إذا تنشطت بتطلب من الخلية
+
+245
+00:20:49,180 --> 00:20:52,740
+تسوّي الاشي المطلوب اللي هو تنقسم في عندي Growth
+
+246
+00:20:52,740 --> 00:20:56,640
+Factors ودولة راح يكونوا الـ Stimuli from the
+
+247
+00:20:56,640 --> 00:21:00,480
+outside الـ Growth Factors ودولة specific لكل نوع
+
+248
+00:21:00,480 --> 00:21:04,580
+من الخلايا يعني الـ Hemoglobin أو الـ Red Blood
+
+249
+00:21:04,580 --> 00:21:08,190
+Cellsالـ Erythropoietin هو الـ Growth Factor تبعه
+
+250
+00:21:08,190 --> 00:21:13,230
+أو مثلا نقول الـ Azenophils هم الـ Interleukin-5
+
+251
+00:21:13,230 --> 00:21:17,970
+هو اللي بيخليهم يكونوا يتنشطوا مثلا، ففي Growth
+
+252
+00:21:17,970 --> 00:21:20,910
+Factors بس الـ Growth Factor حتى يشتغل و هو برا
+
+253
+00:21:20,910 --> 00:21:26,450
+لازم يكون له Receptor على الـ Cell Surface فدولة
+
+254
+00:21:26,450 --> 00:21:29,790
+في عندي Growth Factors بس خلولي يصير عندي الـ
+
+255
+00:21:29,790 --> 00:21:32,950
+Controlled Proliferation اللي بيعطيني الـ Function
+
+256
+00:21:32,950 --> 00:21:38,780
+المطلوبةوبعدين لما تصير مثلًا بالـ Hematopoiesis
+
+257
+00:21:38,780 --> 00:21:45,020
+للـ White والـ Red والـ Platelets of the blood
+
+258
+00:21:45,020 --> 00:21:49,420
+cells الـ Terminal Differentiation لأنه فيه أنه
+
+259
+00:21:49,420 --> 00:21:54,020
+Transcription Factors وفيه أنه Apoptosis زي أخدته
+
+260
+00:21:54,020 --> 00:21:57,760
+عن الـ Fast Fast Ligand Interaction This is one of
+
+261
+00:21:57,760 --> 00:22:04,950
+the mainStimuli أو Direct Orders for Cells to Die
+
+262
+00:22:04,950 --> 00:22:09,450
+in Programmed Cell Death اللي هو الـ Apoptosis الـ
+
+263
+00:22:09,450 --> 00:22:13,590
+Apoptosis مختلف عن الـ Necrosis الـ Necrosis اللي
+
+264
+00:22:13,590 --> 00:22:20,130
+هو بيكون الخلية بتموت بانفجار وبكون يعني فيه
+
+265
+00:22:20,130 --> 00:22:24,270
+Inflammatory Response الـ Apoptosis الخلية بتتحلل
+
+266
+00:22:24,270 --> 00:22:31,730
+بتتحول إلى كتل صغير من الأكل والـوالـ Proteins
+
+267
+00:22:31,730 --> 00:22:35,490
+والـ Amino Acids والـ Sugars والـ Lipids وبتلتحك
+
+268
+00:22:35,490 --> 00:22:39,270
+بالخلايا اللي حواليها يعني الـ Apoptosis عادة في
+
+269
+00:22:39,270 --> 00:22:42,870
+تحت الميكروسكوب ما بنشوفه ممكن نشوف الخلايا وهي
+
+270
+00:22:42,870 --> 00:22:50,510
+تمقسم بس لما نتموت عادة ما بنشوفهاش كثير فهذه
+
+271
+00:22:53,500 --> 00:22:58,560
+الخطوات الرئيسية والسطحيات لعمل
+
+272
+00:22:58,560 --> 00:23:01,180
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+273
+00:23:01,180 --> 00:23:01,980
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+274
+00:23:01,980 --> 00:23:02,260
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+275
+00:23:02,260 --> 00:23:03,020
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+276
+00:23:03,020 --> 00:23:03,480
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+277
+00:23:03,480 --> 00:23:04,040
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+278
+00:23:04,040 --> 00:23:04,040
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+279
+00:23:04,040 --> 00:23:06,800
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+280
+00:23:06,800 --> 00:23:13,860
+عملية عملية عملية عملية ععن طريق الـDNA Repair
+
+281
+00:23:13,860 --> 00:23:18,560
+Proteins فيه Certain Enzymes وCertain Molecules
+
+282
+00:23:18,560 --> 00:23:26,440
+اللي يعني تحفظ جودة الـReplication من الـDNA لكي
+
+283
+00:23:26,440 --> 00:23:31,280
+لا يحصل أي خطأ في القراءة وبالنسبة لفيه الـProcess
+
+284
+00:23:31,280 --> 00:23:39,460
+of CBG DNA Methylation بـCertain Sites أو
+
+285
+00:23:39,460 --> 00:23:40,920
+Hydroxymethylation
+
+286
+00:23:43,950 --> 00:23:48,830
+وDNA Modification Enzymes هاي بتمثل الـ Epigenetic
+
+287
+00:23:48,830 --> 00:23:53,030
+Control اللي هو بتحكم أي جروب من الجينات هم اللي
+
+288
+00:23:53,030 --> 00:23:55,810
+بيصير اللي لهم الـ Gene Expression مش كل الجينات
+
+289
+00:23:55,810 --> 00:23:59,210
+في كل الخلايا كلهم بيشتغلوا لأ في كل نوع من
+
+290
+00:23:59,210 --> 00:24:04,150
+الخلايا في certain genes that are activated others
+
+291
+00:24:04,150 --> 00:24:08,090
+are suppressed فهذا كله من خلال الـ Epigenetic
+
+292
+00:24:08,090 --> 00:24:13,340
+ControlControl ويله الـ Many Mechanisms زي الـ DNA
+
+293
+00:24:13,340 --> 00:24:16,920
+Methylation، DX Methylation الـ Stone Modification
+
+294
+00:24:16,920 --> 00:24:22,600
+والـ mRNA Control، الـ Micro RNA Control هدولة
+
+295
+00:24:22,600 --> 00:24:27,160
+كلهم Epigenetic Control فكل هما دولة في
+
+296
+00:24:27,160 --> 00:24:33,540
+Interaction بينهم وبين بعض حتى يتم لما نيجي نتطلع
+
+297
+00:24:33,540 --> 00:24:40,660
+على الـ Cancer Cellsفي عدة ملاحظات، هناك خسارة من
+
+298
+00:24:40,660 --> 00:24:45,900
+الـ Genomic Integrity يعني ممكن أنا حكيتها مرة
+
+299
+00:24:45,900 --> 00:24:49,580
+كلمة إنه في certain cancers نلاقي بعض اللي لما
+
+300
+00:24:49,580 --> 00:24:56,480
+تاخد يعني هنا أنت أخدت نفس الخلايا السرطانيةحاولت
+
+301
+00:24:56,480 --> 00:24:59,740
+تدرس شو فارقة بالـ «DNA» والـ «Genetics» أو الـ
+
+302
+00:24:59,740 --> 00:25:04,200
+«Genomics» عن الخلايا الطبيعية ففيه «Loss of
+
+303
+00:25:04,200 --> 00:25:11,600
+Genomic Integrity» «Replication» «Segregation» مش
+
+304
+00:25:11,600 --> 00:25:16,540
+مظبوط، احنا غلطنا فـ «DNA Replication Repair»
+
+305
+00:25:16,540 --> 00:25:20,940
+«Chromosome Stability and Segregation» «Abnormal
+
+306
+00:25:20,940 --> 00:25:24,300
+Epigenetic Control» طبعا يعني هنا الـ «DNA Repair
+
+307
+00:25:24,300 --> 00:25:29,780
+Protein»يعني لما يكون هذا موجود، هي كارثة بتخلي
+
+308
+00:25:29,780 --> 00:25:36,520
+هذا الإنسان معرض جداً يكون عنده سرطان في إيمان
+
+309
+00:25:36,520 --> 00:25:44,520
+بدأت تتكلم، احكي ماشي،
+
+310
+00:25:44,520 --> 00:25:52,540
+فبالنسبة لكل الـ Normal steps if anomalies occur
+
+311
+00:25:52,540 --> 00:25:56,060
+أو if problems occurسيسببون في نهاية الحصول على
+
+312
+00:25:56,060 --> 00:26:01,900
+الـCancer عدد المعاملات أو عدد المصطلحات أو عدد
+
+313
+00:26:01,900 --> 00:26:02,040
+المصطلحات أو عدد المصطلحات أو عدد المصطلحات أو عدد
+
+314
+00:26:02,040 --> 00:26:08,020
+المصطلحات أو عدد المصطلحات أو عدد المصطلحات أو عدد
+
+315
+00:26:08,020 --> 00:26:08,700
+المصطلحات أو عدد المصطلحات أو عدد المصطلحات أو عدد
+
+316
+00:26:08,700 --> 00:26:08,800
+المصطلحات أو عدد المصطلحات أو عدد المصطلحات أو عدد
+
+317
+00:26:08,800 --> 00:26:14,720
+المصطلحات أو عدد المصطلحات أو عدد المصطلحات أو عدد
+
+318
+00:26:14,720 --> 00:26:21,900
+المصطلحات أو عدد المصطلحات أو عدد المصطلحات أو عدد
+
+319
+00:26:21,900 --> 00:26:23,760
+المصطلح
+
+320
+00:26:26,440 --> 00:26:29,140
+متحكمين ممتازين من التحكم الطبيعي
+
+321
+00:26:29,140 --> 00:26:50,720
+‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏
+
+322
+00:26:54,380 --> 00:26:58,620
+اللي بوحدهم كلهم، Radiation وChemicals وViral
+
+323
+00:26:58,620 --> 00:27:03,240
+Infection وDrugs وغيره وغيره وغيره، بالأخير كلهم
+
+324
+00:27:03,240 --> 00:27:07,700
+بيخربوا الـDNA كلهم بيخربوا، بيشتغلوا على الـ…
+
+325
+00:27:07,700 --> 00:27:13,060
+الـ… الـGene Axis تبع الـCell Division من جهة
+
+326
+00:27:13,060 --> 00:27:17,880
+والـCell Proliferation والـApoptosis والنقاط هذه
+
+327
+00:27:17,880 --> 00:27:24,510
+فهي الـGeneral View of the Lectureمنعقد الموضوع
+
+328
+00:27:24,510 --> 00:27:32,810
+أكثر ونحكي بعض الأمثلة أيها الكريم أحكي الله عفوك
+
+329
+00:27:32,810 --> 00:27:37,350
+يا دكتور الله عفوك، فضل بالنسبة لخلايا السرطان
+
+330
+00:27:37,350 --> 00:27:40,370
+اللي نزلت عنها في الـStudy اللي حدثت مش هارد أن
+
+331
+00:27:40,370 --> 00:27:42,990
+تكون الخلال في كل مراحل الـcycle أو في كل مراحل
+
+332
+00:27:42,990 --> 00:27:47,050
+الـkill على طول حياتك عشان تكون في الخلال في مرحلة
+
+333
+00:27:47,050 --> 00:27:52,590
+واحدةنعم، عيد السؤال وعلي صوتك، قريبًا أنا رافع
+
+334
+00:27:52,590 --> 00:27:56,890
+صوت عندي على خير، مش سامعك كثير، كله إن الخلايا
+
+335
+00:27:56,890 --> 00:28:01,230
+السرطانية كمان عندها cell cycle، طبعًا، بس هذا فيه
+
+336
+00:28:01,230 --> 00:28:06,810
+abnormality عادة ال cycle، ولكن عشان يصير مثلًا،
+
+337
+00:28:06,810 --> 00:28:11,270
+يصير lung cancer أو أي سرطان مثلًا في أي خلية،
+
+338
+00:28:11,270 --> 00:28:14,390
+لازم يصير خلل، مش شرط كل ال cycle فيه خلل، بس كيف
+
+339
+00:28:14,390 --> 00:28:19,060
+مرحلة واحدة يصير خلل، بدلة سرطانلأ، لأ، لأ، لأ،
+
+340
+00:28:19,060 --> 00:28:26,780
+اسمع عليه إحنا بالأخير مثلًا مثلًا الـ Tissue زي
+
+341
+00:28:26,780 --> 00:28:34,680
+الـ Lung في مثلًا نفترض مليون سلب مثلًا نفترض هيكي
+
+342
+00:28:34,680 --> 00:28:40,700
+هذولة الأصل إنه مثلًا يعني تقريبًا واحدة بالألف من
+
+343
+00:28:40,700 --> 00:28:46,480
+كل خلية بتنقسم مرة باليوم فإنت المتوقع إنهمنها
+
+344
+00:28:46,480 --> 00:28:52,080
+المليون فيه ألف كل يوم بنقسمه بس حتى تكون الأمور
+
+345
+00:28:52,080 --> 00:28:54,880
+stable وتشوف الـ tissue زي ما هو يعني أنا مثلا
+
+346
+00:28:54,880 --> 00:29:02,720
+الجلد عندي أنا شايفه نفس الحجم، مااختلفش فاللي
+
+347
+00:29:02,720 --> 00:29:09,960
+بيصير أن هالألف اللي انقسموا وصاروا ألفين مقابلهم
+
+348
+00:29:09,960 --> 00:29:16,310
+فيه ألف راح يموتبحيث إنه يظل الرقم مليون ويظل كل
+
+349
+00:29:16,310 --> 00:29:22,130
+يوم ألف يولدوا جديد يعني تكون ألفين اجداد ونخسر
+
+350
+00:29:22,130 --> 00:29:26,590
+ألف بالـ Apoptosis ويظل العدد زي ما هو لما تقول
+
+351
+00:29:26,590 --> 00:29:33,010
+سرطان أنت هذا المليون في مكان صار مليون وربع،
+
+352
+00:29:33,010 --> 00:29:38,090
+مليون ونص، مليونين، تلات ملايين، أربع ملايين فعدد
+
+353
+00:29:38,090 --> 00:29:43,990
+الخلايا عادة بزيدممكن هذا لأن الإنقسام صار أسرع أو
+
+354
+00:29:43,990 --> 00:29:50,150
+إن الخلايا بطلة تموت يعني إنت كان عندك ألف صاروا
+
+355
+00:29:50,150 --> 00:29:54,270
+ألفين لأن ألف خلية انقسمت بس بدل ما يموت ألف مات
+
+356
+00:29:54,270 --> 00:30:00,430
+خمسمية فبتصير أنت بالمحصلة عندك بدل ما هو ألف صار
+
+357
+00:30:00,430 --> 00:30:05,930
+ألف وخمسمية زيادة فلما تشوف أنت tumor معناته يا
+
+358
+00:30:05,930 --> 00:30:13,570
+إما increased cell divisionأو Decreased Apoptosis
+
+359
+00:30:13,570 --> 00:30:19,010
+وبالأخير، حتى يصير ورم، يعني كتلة إضافية مش الكتلة
+
+360
+00:30:19,010 --> 00:30:22,030
+النمو الطبيعي اللي بدك إياها أو اللي موجود أو الـ
+
+361
+00:30:22,030 --> 00:30:27,470
+Control فحتى يكون هذا، عدد الخلايا لازم يزيد يعني
+
+362
+00:30:27,470 --> 00:30:31,450
+هي فيها تلقائي راح تكون، إن شاء الله واضح يا كريم
+
+363
+00:30:31,450 --> 00:30:37,750
+عرفت، دعوني أسألك دعوني أسألك دعوني أسألك دعوني
+
+364
+00:30:37,750 --> 00:30:38,930
+أسألك دعوني أسألك دعوني أسألك
+
+365
+00:30:42,810 --> 00:30:47,530
+أه مالك؟ هل جيتها أنت قولت اللي بقى اللي فيها ال
+
+366
+00:30:47,530 --> 00:30:53,790
+cancer؟ أه الأولى؟ لأ ال fourth، ال رابعة تصبح ال
+
+367
+00:30:53,790 --> 00:30:58,610
+رابعة فيها ال .. في ال رابعة أه هل جيتها عشان فيه
+
+368
+00:30:58,610 --> 00:31:02,970
+رفلية فيها cancer أو فيه فيها normal growth؟ لازم
+
+369
+00:31:02,970 --> 00:31:05,410
+في خلال في مرحلة واحدة من المراحل؟ ولا كل مراحل
+
+370
+00:31:05,410 --> 00:31:12,420
+هذه لازم فيها خلال؟ يا دكتورفي كل نوع من السرطانات
+
+371
+00:31:12,420 --> 00:31:18,000
+فيه بشكل أوضح وأكبر يمكن إنه نوع معين من الـ
+
+372
+00:31:18,000 --> 00:31:21,620
+Anomalies مش كلهم راح تلاقيهم في كل أنواع
+
+373
+00:31:21,620 --> 00:31:26,300
+السرطانات أو لازم كلهم يكونوا وفي الغالب ما بيكون
+
+374
+00:31:26,300 --> 00:31:30,520
+في أي سرطان بس واحدة هي اللي فيها خلال لازم يكون،
+
+375
+00:31:30,520 --> 00:31:36,010
+حكيتلك Multifactorial يعني فيها أكثر من جانببس
+
+376
+00:31:36,010 --> 00:31:39,770
+اللي، اللي، اللي راح نحكي عنه دلوقتي كأمثلة أكتر
+
+377
+00:31:39,770 --> 00:31:46,190
+يعني هاي لكل أنواع السرطانات بشكل عام ماشي، هسة
+
+378
+00:31:46,190 --> 00:31:51,110
+لما نيجي ناخذ سرطان معين كمثال يمكن الآن اللي
+
+379
+00:31:51,110 --> 00:31:56,250
+اكتشفناه مثلا جانب معين بشكل أوضح بس هو في الأخير
+
+380
+00:31:56,250 --> 00:32:02,550
+حتى يسير السرطان لازم يكون في عندي مشكلة في أحد
+
+381
+00:32:02,550 --> 00:32:08,250
+هذه الجوانبفيه تفاوت يمكن في حسب ما هو حسب انت شو
+
+382
+00:32:08,250 --> 00:32:15,290
+درسته ودراسة هذه المواضيع للأسف صعبة جدا يعني انك
+
+383
+00:32:15,290 --> 00:32:22,880
+انت تكون عندك قدرة مثلا واللهأشوف الـ «DNA repair»
+
+384
+00:32:22,880 --> 00:32:26,680
+أو «replication» في السرطان اللي فلاني بدي أخد
+
+385
+00:32:26,680 --> 00:32:30,680
+السخلايا و بدي أعيشهم في المختبر و بدي أخليهم
+
+386
+00:32:30,680 --> 00:32:33,880
+ينقسموا و بدي أدرس الـ«repair» ولا
+
+387
+00:32:33,880 --> 00:32:38,540
+الـ«replication» ولا بدي كذا، يعني هي أمر بيستهل،
+
+388
+00:32:38,540 --> 00:32:46,450
+بس الفكرة أن هذا اللي موجود في كل عموم السرطانةهي
+
+389
+00:32:46,450 --> 00:32:50,850
+ملخص لكل أنواع السرطانات يكون فيه لازم يكون أكتر
+
+390
+00:32:50,850 --> 00:32:56,950
+من مشكلة واحدة يعني في الغالب مش مشكلة وحيدة فقط
+
+391
+00:32:56,950 --> 00:33:00,830
+يعني دايماً السرطانات والـ Autoimmune Diseases
+
+392
+00:33:00,830 --> 00:33:06,530
+بيقولوا عنها إن فيها Multifactorial Pathology يعني
+
+393
+00:33:06,530 --> 00:33:13,330
+تسبب فيها خلل من أكتر من جهة ماشي، هذه ناحية،
+
+394
+00:33:13,330 --> 00:33:18,630
+الناحية الثانيةيعني قيمة الدراسة هذه وفهم هذا
+
+395
+00:33:18,630 --> 00:33:23,470
+المواضيع زي ما راح نحكي في جزء منه في الأخير قضية
+
+396
+00:33:23,470 --> 00:33:30,150
+إنه إذا اكتشفت إنه لنوع سرطان معين a certain
+
+397
+00:33:30,150 --> 00:33:36,790
+pathology is the most important واستطعت to develop
+
+398
+00:33:36,790 --> 00:33:41,050
+a certain type of drug or treatment to counteract
+
+399
+00:33:41,050 --> 00:33:48,060
+it، to change itربما يكون لديك إجابة أو إجابة يعني
+
+400
+00:33:48,060 --> 00:33:51,000
+زي راح ناخد بعدين الـ Transcription Factor
+
+401
+00:33:51,000 --> 00:33:55,640
+Inhibitor الـ Tyrosine Kinase Inhibitor هدولة في
+
+402
+00:33:55,640 --> 00:34:00,840
+بعض أنواع السرطانات ممتازة جدا ويعني فتح وطيور
+
+403
+00:34:00,840 --> 00:34:06,300
+علاج خيالي يعني بتعتبره فالفهم المواضيع هذه
+
+404
+00:34:06,300 --> 00:34:11,340
+المقصود الآن في المرحلة هذه إنه إحنا لازم يكون
+
+405
+00:34:11,340 --> 00:34:16,510
+عندنا استيعاب لشو هيالخطوات المسببة للسرطان
+
+406
+00:34:16,510 --> 00:34:23,830
+وبالتالي هي نوع من الاحتماليات أو تعطينا أفكار على
+
+407
+00:34:23,830 --> 00:34:29,410
+كيفية علاجه، ورح ناخد أمثلة عليه، الآن ما بتكلم عن
+
+408
+00:34:29,410 --> 00:34:34,490
+سرطان محدد، وكل أنواع خلايا الجسم ممكن تتحول
+
+409
+00:34:34,490 --> 00:34:39,350
+للسرطانيعني المكان الوحيد اللي ما عمري سمعت إنه
+
+410
+00:34:39,350 --> 00:34:44,730
+بتتكون فيه سرطان هو الجزء الأول أو الثاني من الـ12
+
+411
+00:34:44,730 --> 00:34:47,970
+يعني
+
+412
+00:34:47,970 --> 00:34:52,870
+هذا النوع، هذا المكان في الجسم من النادر أو عمري
+
+413
+00:34:52,870 --> 00:34:56,270
+ما سمعت إنه فيه سرطان في الـDeudenum في هذا
+
+414
+00:34:56,270 --> 00:34:59,190
+المكان، سرطان في الصمم، في الـOesophagus، في
+
+415
+00:34:59,190 --> 00:35:02,350
+الـSmall Intestine، بالـLarge Intestine، مش عارف
+
+416
+00:35:02,350 --> 00:35:07,330
+إيشبتلاقي كل أنواع الجسم بتلاقي فيه سرطانات جلد،
+
+417
+00:35:07,330 --> 00:35:12,850
+دم، عصاب، عظام أي نوع خلايا بيمكن تتحول للسرطان
+
+418
+00:35:12,850 --> 00:35:21,910
+وهي كله بيكون في الـ… شو اسمه؟ بيكون من الـ…
+
+419
+00:35:21,910 --> 00:35:27,250
+الـAbnormality البطارية كانت تتضعف فهي كلها بيشير
+
+420
+00:35:27,250 --> 00:35:31,800
+Abnormality بالنسبة للـCell Cycle Regulationبالـ
+
+421
+00:35:31,800 --> 00:35:35,180
+«DNA»، يعني بالأخير في مشكلة في الـ «DNA» أتأمل
+
+422
+00:35:35,180 --> 00:35:40,420
+النقطة واضحة يا كريم أهلا و شكرا يا دكتور أهلا
+
+423
+00:35:40,420 --> 00:35:48,240
+وسهلا فالآن العلماء
+
+424
+00:35:48,240 --> 00:35:56,080
+أو التدارسين للمواضيع هذه لكل نوع من السلطنات
+
+425
+00:35:56,080 --> 00:36:03,090
+أحيانًا بينجحواإنه يتعرفوا أو يعرفوا الـ «site»
+
+426
+00:36:03,090 --> 00:36:07,970
+حسب ما راح نتفرج بعدين كيف درسوها وكيف اكتشفوها
+
+427
+00:36:07,970 --> 00:36:12,550
+إنه السرطان اللي فلاني في المكان اللي فلاني فيه
+
+428
+00:36:12,550 --> 00:36:17,670
+جين محدد هو اللي بيكون فيه certain mutations،
+
+429
+00:36:17,670 --> 00:36:22,270
+anomalies، changes فيحيث إنه بيعطينا بالأخير
+
+430
+00:36:22,270 --> 00:36:33,230
+السرطان هذا فالـ «جين» المسؤول عن تكوين أحيانًا
+
+431
+00:36:33,230 --> 00:36:38,470
+الـ «بروتين» related to that type of cancer أو
+
+432
+00:36:38,470 --> 00:36:42,450
+للكترول في نوع معين من الـ «كانسر» بيسموه «proto
+
+433
+00:36:42,450 --> 00:36:46,630
+-oncogene» «onco» for cancer «oncology» يعني علم
+
+434
+00:36:46,630 --> 00:36:50,630
+السرطان هذا المحفز
+
+435
+00:36:50,630 --> 00:36:56,600
+لنمو السرطان المعين هذالكل نوع ورح نشوف أمثل عليهم
+
+436
+00:36:56,600 --> 00:37:05,100
+بدنا نسميه هيك بشكل عام «Proto-Oncogene» فإذا كان
+
+437
+00:37:05,100 --> 00:37:10,700
+هذا الجين المطلوب منه ينتج بروتين معين الأصل كان
+
+438
+00:37:10,700 --> 00:37:16,820
+كمية قليلة أو كمية معينة وكذا الـ… الـ…
+
+439
+00:37:16,820 --> 00:37:20,540
+الـAnomalies that you can expect and try to find
+
+440
+00:37:20,540 --> 00:37:23,860
+what type of problem there isبإمكانها أن يكون هناك
+
+441
+00:37:23,860 --> 00:37:29,340
+ميوتيشنات كودية يعني بيعطيك البروتين الهوانة الـ
+
+442
+00:37:29,340 --> 00:37:35,200
+Regulatory mutations الـ الـ ميوتيشن اللي حاطينها
+
+443
+00:37:35,200 --> 00:37:41,680
+يعني تطلع في المنطقة اللي هي جزء من التركيب
+
+444
+00:37:41,680 --> 00:37:47,760
+لبروتين نفسه اللي موجود أكتر في الـ Cancer ماشي
+
+445
+00:37:47,760 --> 00:37:52,980
+فهذه بعض الـ mutations بتكون بهذا الشكل أحياناًحتى
+
+446
+00:37:52,980 --> 00:37:59,360
+يصير الـ Extraction لأي جين في الـ Regulatory يعني
+
+447
+00:37:59,360 --> 00:38:05,880
+الـ Promoter Area، الـ Initiator Area المنطقة اللي
+
+448
+00:38:05,880 --> 00:38:10,360
+قبل اللي راح تخلي البروتين هذا ينقرة فهذه
+
+449
+00:38:10,360 --> 00:38:14,880
+Regulatory Mutations في مرات معينة، هناك مشكلة قبل
+
+450
+00:38:14,880 --> 00:38:19,440
+ذلكيعني البروتين الأخير بالأخير راح يطلع نفس
+
+451
+00:38:19,440 --> 00:38:23,120
+البروتين اللي بيكون بالخلية العادية بس هنا كميته
+
+452
+00:38:23,120 --> 00:38:29,420
+أكبر وهذا الاختلاف أحيانًا الـ Translocation مثلًا
+
+453
+00:38:29,420 --> 00:38:33,860
+من قطعة ثانية راح ناخد مثال عليها الـ Philadelphia
+
+454
+00:38:33,860 --> 00:38:38,700
+chromosome نسميه بيكون اللي بيطلع عندي بروتين
+
+455
+00:38:38,700 --> 00:38:43,340
+مختلف تمامًا وظيفته أحيانًا مختلفةوأحيانًا في عندي
+
+456
+00:38:43,340 --> 00:38:47,980
+gene amplification هنا نفس الـ gene ككمية بس
+
+457
+00:38:47,980 --> 00:38:52,380
+الوظيفة صارت أقوى بكتير وأحيانًا بيكون أنه بيصير
+
+458
+00:38:52,380 --> 00:38:57,420
+عندي amplification بدل ما يكون عندي one copy of
+
+459
+00:38:57,420 --> 00:39:01,600
+that gene بيصير عندي multiple copies ويكون بالتالي
+
+460
+00:39:01,600 --> 00:39:05,420
+إذا كلهم صارلهم transcription فهيصير برضه عندي
+
+461
+00:39:05,420 --> 00:39:08,560
+excessive amount of the protein which is normal أو
+
+462
+00:39:08,560 --> 00:39:13,790
+similar to the original proteinهذه كلها ميكانيزمات
+
+463
+00:39:13,790 --> 00:39:17,130
+ميوتيشيالية تؤدي إلى اكتفاء البروتو-أنكوجين
+
+464
+00:39:17,130 --> 00:39:21,550
+أحياناً تحصل عندها اكتفاء كبير في أماكن معينة
+
+465
+00:39:21,550 --> 00:39:27,890
+وتكون نتيجة أنواع الاختلالات هذه سواء في الـCoding
+
+466
+00:39:27,890 --> 00:39:32,250
+Mutation أو الـRegulatory Mutation أو التغيير أو
+
+467
+00:39:32,250 --> 00:39:36,230
+التعيين من مجموعة أخرى مع مفعولة بروتين جديد أو
+
+468
+00:39:36,230 --> 00:39:40,780
+بروتين جديد تعمل أكتر أو أقلأو على الـGene
+
+469
+00:39:40,780 --> 00:39:47,740
+Amplification فهذه ميكانيزات مختلفة أحنا عادةً
+
+470
+00:39:47,740 --> 00:39:52,360
+الـNormal Cell نتوقعها
+
+471
+00:39:52,360 --> 00:39:58,260
+تظلها بشكل معيّر الـStages بيحصل أولاً بـIncreased
+
+472
+00:39:58,260 --> 00:40:02,760
+Proliferation وبتكون إنه صارت أندي خلل في مكان A
+
+473
+00:40:04,210 --> 00:40:08,950
+وبعدين صار عندى mutation in site B وبعدين عندي
+
+474
+00:40:08,950 --> 00:40:13,410
+mutation في الـthird place يعني اللي بدى واحد
+
+475
+00:40:13,410 --> 00:40:20,390
+يتذكره إنه إحنا في الغالب ما بنتكلم عن إنه single
+
+476
+00:40:20,390 --> 00:40:24,230
+thing that will lead to the cancer it has to be at
+
+477
+00:40:24,230 --> 00:40:28,670
+multiple sites وبالتالي بعد ال increase
+
+478
+00:40:28,670 --> 00:40:33,140
+proliferation مثلا في الـGIبيعطينا مثلًا الـ
+
+479
+00:40:33,140 --> 00:40:37,200
+Benign Adenoma الـ Adenoma بتكون إنه إزالة الـ
+
+480
+00:40:37,200 --> 00:40:39,900
+proliferation وبتكون it's a benign looking thing
+
+481
+00:40:39,900 --> 00:40:44,880
+هذه بتصير Early Neoplasia، Progressive Neoplasia،
+
+482
+00:40:44,880 --> 00:40:48,600
+مع ال progression أكتر، بيصير عندي بالأخير الـ
+
+483
+00:40:48,600 --> 00:40:53,360
+Carcinoma، والأسوأ نوع اللي هو بيروح بالوطن، يعني
+
+484
+00:40:53,360 --> 00:40:56,940
+بتطور أكتر لإنه يصير Endometastasis، and this is
+
+485
+00:40:56,940 --> 00:41:04,400
+way different than the normal cell.غير الـ
+
+486
+00:41:04,400 --> 00:41:09,380
+Mutations في Multiple Genes الـ Chromosomal
+
+487
+00:41:09,380 --> 00:41:17,000
+Unemployment يعني أنا إذا الـ Normal Tissue بشوف
+
+488
+00:41:17,000 --> 00:41:24,060
+الخلايا 2N doing their work و Stable و بتكون
+
+489
+00:41:24,060 --> 00:41:30,630
+حالياً بتكونفنشينال وكويسة الـ cancer cells
+
+490
+00:41:30,630 --> 00:41:34,670
+وبالذات لما نكون كل ما هو more advanced more
+
+491
+00:41:34,670 --> 00:41:42,810
+metastatic more aggressive ماشي بنلاقي increased
+
+492
+00:41:42,810 --> 00:41:46,910
+genetic anomalies including chromosomal aneuplosis
+
+493
+00:41:46,910 --> 00:41:53,590
+يعني الـ DNA repair و modification و الـ chromatin
+
+494
+00:41:53,590 --> 00:41:57,620
+modification الـ genes هذا بالأولبس كل ما هذه
+
+495
+00:41:57,620 --> 00:42:02,320
+الخلايا بتتكثروا بسرعة كتير السرعة بتخلي احتمالية
+
+496
+00:42:02,320 --> 00:42:06,620
+الأخطاء تصير أكبر وهنا بتصير الأخطاء أكتر على
+
+497
+00:42:06,620 --> 00:42:11,360
+مستوى الـChromosomes كلها مش بس Single Gene أو الـ
+
+498
+00:42:11,360 --> 00:42:16,950
+Proto Oncogene الأول بس فبالتالي لما واحد يشوفالـ
+
+499
+00:42:16,950 --> 00:42:20,590
+Advanced Cancer مثلًا اللي موجود في الـ Metastasis
+
+500
+00:42:20,590 --> 00:42:26,550
+بسهولة بيلاقي 3N، 4N، 8N of Genetic Material
+
+501
+00:42:26,550 --> 00:42:31,870
+Highly Abnormal ويكون هذا جزء من الـ
+
+502
+00:42:31,870 --> 00:42:38,230
+Aggressiveness يعني ليش السرطان هذا سيء وشرس
+
+503
+00:42:38,230 --> 00:42:42,230
+وبيهاجم بسرعة وبينتشر بسرعة؟ فبيكون لأن الـ
+
+504
+00:42:42,230 --> 00:42:44,770
+Control على الجينات سبعته سيء
+
+505
+00:42:47,210 --> 00:42:57,950
+فا I think this يعني slide أو يعني الفكرة تبعته
+
+506
+00:42:57,950 --> 00:43:05,730
+إنه regardless of whatever cancer wherever the
+
+507
+00:43:05,730 --> 00:43:10,170
+cancer occurs sporadically أو individual أو نتيجة
+
+508
+00:43:10,170 --> 00:43:12,770
+من ميوسماتيكية أو مستلزمة أو مستلزمة أو مستلزمة أو
+
+509
+00:43:12,770 --> 00:43:13,030
+مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو
+
+510
+00:43:13,030 --> 00:43:14,650
+مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو
+
+511
+00:43:14,650 --> 00:43:15,030
+مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو
+
+512
+00:43:15,030 --> 00:43:15,030
+مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو
+
+513
+00:43:15,030 --> 00:43:15,030
+مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو
+
+514
+00:43:15,030 --> 00:43:15,030
+مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو
+
+515
+00:43:15,030 --> 00:43:16,660
+مستلزمة أو مستلزمة أو مستيعني حكينا أو يمكن راح
+
+516
+00:43:16,660 --> 00:43:22,580
+نحكي بعد شوية إنه السرطان أحيانًا فيه أشياء منه
+
+517
+00:43:22,580 --> 00:43:27,920
+genetic و inherited يعني راح ناخد أمثلة عليها وبعض
+
+518
+00:43:27,920 --> 00:43:32,880
+الأشياء الموجودة ومعروفة ممكن واحد يدرسها في
+
+519
+00:43:32,880 --> 00:43:39,920
+certain families فسواء هو individual أو سواء هو في
+
+520
+00:43:39,920 --> 00:43:48,660
+family أوكـ Hereditary trait بالأخير السرطان هو
+
+521
+00:43:48,660 --> 00:43:54,700
+Genetic Phenomenon Genetic Disease لأنه سواء الـ
+
+522
+00:43:54,700 --> 00:43:59,480
+Oncogene بالاندويدوال أو إذا بالـ Family ويكون
+
+523
+00:43:59,480 --> 00:44:03,840
+أحياناً فيه tumor suppressor gene على عكس الـ
+
+524
+00:44:03,840 --> 00:44:11,280
+Oncogenes يعني الـ Genes involved in cancerتكون من
+
+525
+00:44:11,280 --> 00:44:15,420
+نوعين مختلفة في الـ Oncogenes اللي بيزودوا السرطان
+
+526
+00:44:15,420 --> 00:44:19,200
+وفي الـ Tumor Suppressor Genes وكثير من الـ Genes
+
+527
+00:44:19,200 --> 00:44:25,260
+ومهمتهم هو تقليل الـ Cancer فإذا هذا النوع من الـ
+
+528
+00:44:25,260 --> 00:44:30,000
+Genes صار له Suppression صار له Inhibition
+
+529
+00:44:30,000 --> 00:44:34,680
+وSuppression لـ Tumor Suppressor Genes فنفي النفي
+
+530
+00:44:34,680 --> 00:44:41,700
+اتباع، وبالتالي بيصير عندي السرطانفهي يعني أنا بظن
+
+531
+00:44:41,700 --> 00:44:50,140
+اقرأوا الجزء هذا ويعني هاي مفاهيم مهمة تداخل بين
+
+532
+00:44:50,140 --> 00:44:57,800
+الـ الـ genes وبالنسبة للـ يعني different types of
+
+533
+00:44:57,800 --> 00:45:03,720
+problems with different types of cancer
+
+534
+00:45:06,060 --> 00:45:10,820
+من الأشياء اللي حكينا عنهم أحيانًا في certain،
+
+535
+00:45:10,820 --> 00:45:15,300
+many types of genes and for different types of
+
+536
+00:45:15,300 --> 00:45:22,520
+cells أنه for any type of cell to either divide أو
+
+537
+00:45:22,520 --> 00:45:28,340
+أحيانًا أبكتوث أو do anything it starts with a
+
+538
+00:45:28,340 --> 00:45:31,740
+certain stimulus اللي هو الـHormone اللي بدنا
+
+539
+00:45:31,740 --> 00:45:38,140
+نسميه الـLigam هناالـ L for Ligand فالـ Ligand حتى
+
+540
+00:45:38,140 --> 00:45:44,220
+يشتغل بذات الـ protein hormones إذا كربوهيرد، إذا
+
+541
+00:45:44,220 --> 00:45:46,460
+lipid كربوهيرد، كربوهيرد، كربوهيرد، كربوهيرد،
+
+542
+00:45:46,460 --> 00:45:47,300
+كربوهيرد، كربوهيرد، كربوهيرد، كربوهيرد، كربوهيرد،
+
+543
+00:45:47,300 --> 00:45:48,060
+كربوهيرد، كربوهيرد، كربوهيرد، كربوهيرد، كربوهيرد،
+
+544
+00:45:48,060 --> 00:45:50,900
+كربوهيرد، كربوهيرد، كربوهيرد، كربوهيرد، كربوهيرد،
+
+545
+00:45:50,900 --> 00:45:54,080
+كربوهيرد، كربوهيرد، كربوهيرد، كربوهيرد، كربوهيرد،
+
+546
+00:45:54,080 --> 00:45:58,840
+كربوهيرد، كربوهيرد،
+
+547
+00:45:58,840 --> 00:46:08,950
+كربالـ Cell Surface Receptor مرات كتير بيكون يعني
+
+548
+00:46:08,950 --> 00:46:15,230
+شوي متبعد عن بعضه لما يصير Interaction بين الـ
+
+549
+00:46:15,230 --> 00:46:21,910
+Cell Surface Receptor مع الـ Ligand تبعه بيصير
+
+550
+00:46:21,910 --> 00:46:27,730
+بيقولوله «confirmational change» يعني شكل البروتين
+
+551
+00:46:27,730 --> 00:46:33,200
+بتغيربنضب على بعض وبتغير فهنا المثال اللي حاطينه
+
+552
+00:46:33,200 --> 00:46:37,440
+إنه بعد ما كانت الـ two chains بعاد عن بعض صار
+
+553
+00:46:37,440 --> 00:46:44,580
+نقراب و became activated مرات كتيرة بكون الـ
+
+554
+00:46:44,580 --> 00:46:48,640
+enzyme which is a kinase اللي هو يعني وظيفة وظيفة
+
+555
+00:46:48,640 --> 00:46:58,810
+phosphate على الـ group بكون incorporatedإلى الـ
+
+556
+00:46:58,810 --> 00:47:05,550
+Cell Surface Receptor يعني يكون جزء منه فلما نكون
+
+557
+00:47:05,550 --> 00:47:08,770
+بعيد، بيكون هذا مش شرذان لما هدول القطعة تانية
+
+558
+00:47:08,770 --> 00:47:15,110
+بعادة عن بعض بعد ما يشوف الـ Cell Surface Receptor
+
+559
+00:47:15,110 --> 00:47:19,370
+يشوف الـLigand أو الهرمون أو الـ Stimulus بيصير
+
+560
+00:47:19,370 --> 00:47:24,210
+اندياaktivation للفعلين بضيف الـ unit of phosphate
+
+561
+00:47:24,210 --> 00:47:34,910
+on itهذه نسميها steps of signal transduction وهنا
+
+562
+00:47:34,910 --> 00:47:38,610
+حاطيني على مثال الـ Retinoplastoma أو الـ
+
+563
+00:47:38,610 --> 00:47:39,550
+Retinoplastoma أو الـ Retinoplastoma أو الـ
+
+564
+00:47:39,550 --> 00:47:39,550
+Retinoplastoma أو الـ Retinoplastoma أو الـ
+
+565
+00:47:39,550 --> 00:47:39,990
+Retinoplastoma أو الـ Retinoplastoma أو الـ
+
+566
+00:47:39,990 --> 00:47:41,070
+Retinoplastoma أو الـ Retinoplastoma أو الـ
+
+567
+00:47:41,070 --> 00:47:41,070
+Retinoplastoma أو الـ Retinoplastoma أو الـ
+
+568
+00:47:41,070 --> 00:47:42,990
+Retinoplastoma أو الـ Retinoplastoma أو الـ
+
+569
+00:47:42,990 --> 00:47:44,410
+Retinoplastoma أو الـ Retinoplastoma أو الـ
+
+570
+00:47:44,410 --> 00:47:44,410
+Retinoplastoma أو الـ Retinoplastoma أو الـ
+
+571
+00:47:44,410 --> 00:47:44,550
+Retinoplastoma أو الـ Retinoplastoma أو الـ
+
+572
+00:47:44,550 --> 00:47:47,310
+Retinoplastoma أو الـ Retinoplastoma أو الـ
+
+573
+00:47:47,310 --> 00:47:49,870
+Retinoplastoma أو الـ Retinoplastoma أو الـ
+
+574
+00:47:49,870 --> 00:47:56,010
+Retinoplastoma أو الـ Retinoplastoma
+
+575
+00:47:56,010 --> 00:47:59,420
+أو الـ Retinالتغيير في تغيير الوصول للإشعار الهاتف
+
+576
+00:47:59,420 --> 00:48:04,520
+بيصير عندي ركوots of multiple proteins and
+
+577
+00:48:04,520 --> 00:48:08,600
+activate other kinases and small g-proteins that
+
+578
+00:48:08,600 --> 00:48:12,500
+in turn activate various transcription factors
+
+579
+00:48:12,500 --> 00:48:20,360
+يعني بالأخير أنا لما مثلا ييجي هرمون على الـ cell
+
+580
+00:48:20,360 --> 00:48:24,740
+surface وتشوف الخلية يتفاعل مع الـ receptor تبعه
+
+581
+00:48:25,650 --> 00:48:29,110
+بالأخير إذا بقى بيصير عندي Cell Division أو New
+
+582
+00:48:29,110 --> 00:48:33,470
+Protein Function لازم الـ Stimulus تصل الـ Nucleus
+
+583
+00:48:33,470 --> 00:48:41,630
+فتبدأ في الغالب بـ Kinases زي الـ Jax الـ Jax Just
+
+584
+00:48:41,630 --> 00:48:45,830
+Another Kinase زي ما يقول وضيفته إنه يعمل
+
+585
+00:48:45,830 --> 00:48:50,770
+Phosphorylation فالـ Phosphorylation هنا بعدين
+
+586
+00:48:50,770 --> 00:48:55,730
+بيكون خطوة أو أكتر هنابالأخير بيصير عندي
+
+587
+00:48:55,730 --> 00:48:59,790
+Transcription Factor Transcription اللي هو Change
+
+588
+00:48:59,790 --> 00:49:07,950
+of DNA to RNA يعني بيفتح الـ DNA في محل معين بيصير
+
+589
+00:49:07,950 --> 00:49:14,750
+له Transcription لـ Messenger RNA فالـ Changes هذه
+
+590
+00:49:15,600 --> 00:49:19,580
+بالأخير حتى يصير عندي cancer الـ end result should
+
+591
+00:49:19,580 --> 00:49:23,000
+be to stimulate proliferation to suppress
+
+592
+00:49:23,000 --> 00:49:27,620
+apoptosis واحدة منها، يعني ياها يا هي، بطريقتين
+
+593
+00:49:27,620 --> 00:49:33,800
+هدولة، فبالأخير احنا بكل السلطنات لازم نحاول نفهم
+
+594
+00:49:33,800 --> 00:49:41,370
+ال steps هذهوأحيانًا هذه تعطينا بالأول رؤية ونظرة
+
+595
+00:49:41,370 --> 00:49:46,470
+وفهم لليش السرطان اتكوّن بس ممكن تعطينا حلول في
+
+596
+00:49:46,470 --> 00:49:50,050
+بعض أنواع السرطانات زي ما راح نشوف كمان بعد شوية
+
+597
+00:49:50,050 --> 00:49:54,110
+في أسئلة؟
+
+598
+00:49:54,110 --> 00:50:04,610
+الآن في أمثلة على الـTumour Suppressor Genes يعني
+
+599
+00:50:04,610 --> 00:50:10,690
+الصراحةالأمثلة هذولة والجينات اللي راح نحكي عنهم
+
+600
+00:50:10,690 --> 00:50:18,250
+ونلاحظ عليهم أنه صرنا نعرف عنهم من دراسة خلايا
+
+601
+00:50:18,250 --> 00:50:27,390
+السرطانات وتبعات المرضى يعني هنا حاطين في حالات
+
+602
+00:50:27,390 --> 00:50:32,390
+الـSporadic Cases الـRetinoplastoma مثلا لهذا
+
+603
+00:50:32,390 --> 00:50:40,740
+الأشيأنا بدي يعني اتطلع على كل الجدول هذا ماشي بدي
+
+604
+00:50:40,740 --> 00:50:47,040
+بس تحفظوا Bracket 1 و Bracket 2 ماشي الـ Bracket 1
+
+605
+00:50:47,040 --> 00:50:55,080
+يعني حتى زي ما بقول الواحد يتذكرها يعني بدنا نطلع
+
+606
+00:50:55,080 --> 00:50:58,380
+شوية يعني هي في الطب يعني بس بدنا ندخل على التمثيل
+
+607
+00:50:58,380 --> 00:51:03,340
+شويةمن الممثلات المشهورات «واجونة على الأردن»
+
+608
+00:51:03,340 --> 00:51:07,280
+«زاروا مخيمات اللاجئين» «ولها نشاط إنساني»
+
+609
+00:51:07,280 --> 00:51:15,140
+«أنجلينا جولي» تسمعوا فيها صح؟ ممثلة مشهورة اللي
+
+610
+00:51:15,140 --> 00:51:22,700
+حدا بيشوف أفلام بيلاقيها يعني معروفة هاي الممثلة
+
+611
+00:51:22,700 --> 00:51:26,380
+عندها «very strong family history of bilateral
+
+612
+00:51:26,380 --> 00:51:28,320
+breast cancer»
+
+613
+00:51:30,430 --> 00:51:35,730
+والـ Braca 1 طلع Positive عندها و Two Doses فعملت
+
+614
+00:51:35,730 --> 00:51:40,230
+Breast يعني Mastectomy Bilateral وهي ما عندهاش
+
+615
+00:51:40,230 --> 00:51:46,470
+سرطانات فالـ ال .. ال .. بالذات الـ Braca 1 و
+
+616
+00:51:46,470 --> 00:51:52,370
+Braca 2 إذا بدك تنسى بقية الأشياء ماشي انساهن بس
+
+617
+00:51:52,370 --> 00:51:57,590
+هدولة احفظهن كمثال على هذا الأمر ماشي
+
+618
+00:51:59,870 --> 00:52:08,270
+فالـ يعني راح نشوف بعدين كيف تم عملية اكتشاف إن
+
+619
+00:52:08,270 --> 00:52:12,050
+هذا الـ gene هو المسؤول أو إشي قريب من هذا المكان
+
+620
+00:52:12,050 --> 00:52:14,430
+هو المسؤول عن السرطان هذا
+
+621
+00:52:18,220 --> 00:52:24,080
+فالأنواع يعني Retinoblastoma I ولقوا بعدين الـ
+
+622
+00:52:24,080 --> 00:52:27,960
+Protein تبعه ثواني يا كريم أخلص الجملة وبعدين
+
+623
+00:52:27,960 --> 00:52:34,920
+بخليك تسأل الـ TP53 يعني لاحظوا الشغل الـ Gene
+
+624
+00:52:34,920 --> 00:52:41,740
+دائماً كبتة Letter الـ Gene Product والبروتين
+
+625
+00:52:41,740 --> 00:52:46,860
+بيحطوه Small Letter أحياناًإحنا على الـMolecular
+
+626
+00:52:46,860 --> 00:52:53,220
+Weight يعني مثلًا مرات بيسموه Protein بيه 110 وزنه
+
+627
+00:52:53,220 --> 00:53:01,100
+110 بيه Protein بيه GP 160، GP 120، GP 41 تبعين
+
+628
+00:53:01,100 --> 00:53:07,460
+الـHIV وغيره وغيره فهي لها معاني بالنسبة لكيف على
+
+629
+00:53:07,460 --> 00:53:11,340
+شو بندور فالـ…
+
+630
+00:53:11,340 --> 00:53:16,220
+فيه a lot of cancersWe said they can be familial
+
+631
+00:53:16,220 --> 00:53:19,980
+ويكون يعني strong association with certain types
+
+632
+00:53:19,980 --> 00:53:26,060
+of genes و الـ BRCA1 و BRCA2 بالـ breast cancer و
+
+633
+00:53:26,060 --> 00:53:30,300
+الـ ovarian cancer والأنواع الثانية في الأنواع
+
+634
+00:53:30,300 --> 00:53:35,880
+الثانية أنا مش عارفهم كتير يعني بده الواحد لما
+
+635
+00:53:35,880 --> 00:53:42,750
+ييجي يتعامل مع حاله يحاول عشان يفهم ليش الـالمرض
+
+636
+00:53:42,750 --> 00:53:46,430
+الإفلاني، الدواء الإفلاني بيفيدني، اتفضل يا كريم
+
+637
+00:53:46,430 --> 00:53:50,030
+كريم
+
+638
+00:53:50,030 --> 00:53:53,650
+كيف تواجد الجين هذا الأول في جسم الإنسان حد ما
+
+639
+00:53:53,650 --> 00:53:59,290
+ممكن يؤدي لتحرى ويهدى السلطان؟ إيش هو؟ مرة ثانية
+
+640
+00:53:59,290 --> 00:54:04,670
+تواجد الجين الأول، لو يتواجد هي في جسم الإنسان،
+
+641
+00:54:04,670 --> 00:54:08,710
+هذا بلقى …ما فهمتش قانون الجين الأول، مافهمتش،
+
+642
+00:54:08,710 --> 00:54:09,490
+فهمني السؤال
+
+643
+00:54:13,030 --> 00:54:16,790
+في العمول الأول، اللي فيه الجينات، لو أي جين يهدف
+
+644
+00:54:16,790 --> 00:54:19,630
+إلى جسد الجسم، هذا بقدر لنسبة كبيرة، يعني إن الناس
+
+645
+00:54:19,630 --> 00:54:22,410
+بيتسرطر… –لو أي جين من الجسم، من هدول الجينات،
+
+646
+00:54:22,410 --> 00:54:27,650
+ماله؟ –مثلا، عليك تقولي مدرسة، ده سهل، لو هدفت
+
+647
+00:54:27,650 --> 00:54:29,670
+واحدة لجسم الإنسان، يعني لنسبة كبيرة إنه هيكي
+
+648
+00:54:29,670 --> 00:54:34,210
+يتسرط أو يتسرط كذا؟ –لأ، لأ، هم هدول الجينات، كل
+
+649
+00:54:34,210 --> 00:54:39,090
+غالب، لأ، وهن الأصل إنهم موجودات، بس certain قليل،
+
+650
+00:54:39,090 --> 00:54:45,320
+certain mutationبشكل معين هي اللي بتعطينا إنه
+
+651
+00:54:45,320 --> 00:54:51,320
+الارتباط مع السرطان يعني الـ RB1 هذا بالـ
+
+652
+00:54:51,320 --> 00:54:54,800
+Retinoblastoma اللي هي نوع من السرطان، وهنا بتكون
+
+653
+00:54:54,800 --> 00:55:00,500
+familial بالأخر هو Cell Cycle Regulator، ماشي؟
+
+654
+00:55:00,500 --> 00:55:04,820
+وإله دخل في أكتر من شغل يعني بالـ Retinoblastoma،
+
+655
+00:55:04,820 --> 00:55:08,400
+بالـSmall Cell Cancer، بالـBreast Cancer لأخو مثل
+
+656
+00:55:08,400 --> 00:55:14,790
+هذا البروتين، إله دخلفاهم عليك كيف؟ هدولة الجينات
+
+657
+00:55:14,790 --> 00:55:20,850
+الأصل إن هما موجودين وطبيعية بس هنا إحنا بنحطهم
+
+658
+00:55:20,850 --> 00:55:28,850
+كمثال على جين هو بالأصل وظيفته إنه يكون suppressor
+
+659
+00:55:28,850 --> 00:55:33,570
+gene tumor suppressor gene بحيث إنه هاي الـnormal
+
+660
+00:55:33,570 --> 00:55:40,050
+function تبعه فلما يكون فيصير disorderماشي أو
+
+661
+00:55:40,050 --> 00:55:46,410
+mutation أو anomaly بشكل معين بنتج عنه سرطان معين
+
+662
+00:55:46,410 --> 00:55:52,310
+زي هذه الأنواع لكل نوع عشان الممثل هذه احفظ الـ
+
+663
+00:55:52,310 --> 00:55:59,030
+Brachia 1 و Brachia 2 ماشي يعني الصراحة يا كريم
+
+664
+00:55:59,030 --> 00:56:07,090
+أسماء الجينات وشو المرض اللي بتسوي ما أظن حد بيقدر
+
+665
+00:56:07,090 --> 00:56:11,990
+يحفظهبس RB يعني Retinoblastoma يمكن واضحة شوية
+
+666
+00:56:11,990 --> 00:56:17,250
+المقال البقية، ليش علاقتها بهذا السرطان، شو دخلها
+
+667
+00:56:17,250 --> 00:56:21,670
+و ليش هيك و ليش هيك، مابعرف وما أظن يعني إذا أنت
+
+668
+00:56:21,670 --> 00:56:26,570
+ماكنت متخصص إنك بدك تدرس هذا الجانب إنه إيه له
+
+669
+00:56:26,570 --> 00:56:34,460
+قيمة عندك يعني، ماشي؟فاحنا بس خلّينا يعني نفهم الـ
+
+670
+00:56:34,460 --> 00:56:41,580
+Concept إنه يعني الـ Mutation في هذا الـ Site can
+
+671
+00:56:41,580 --> 00:56:48,600
+be tested وبالتالي أحيانًا نستفيد منها إنه مثلًا
+
+672
+00:56:48,600 --> 00:56:54,660
+والله يعني راح نشوف بعدين إنه اللي بيكون عنده هذا
+
+673
+00:56:54,660 --> 00:56:59,150
+النوع ممكن فيه دوة معينة بيفيدهشايف علي؟ ممكن إذا
+
+674
+00:56:59,150 --> 00:57:02,530
+شُكت كتير من هذه الأشكال أنا بدي أفرّق هل هي
+
+675
+00:57:02,530 --> 00:57:06,350
+cancerous ولا pre-cancerous اللي هي يعني لسه
+
+676
+00:57:06,350 --> 00:57:13,430
+benign فوجود الـ الـ الـ mutations بشكل معين في
+
+677
+00:57:13,430 --> 00:57:18,130
+أشياء معينة يخليني أشك أكتر إنه سرطان أو
+
+678
+00:57:18,130 --> 00:57:21,590
+aggressive أو يفيدوا إشي أو كده يعني أنا ضربتلك
+
+679
+00:57:21,590 --> 00:57:27,220
+مثال على الـ BRCA1 و BRCA2للممثلة عملت major
+
+680
+00:57:27,220 --> 00:57:32,760
+procedure bilateral mastectomy حطت implants ويعني
+
+681
+00:57:32,760 --> 00:57:38,280
+غيرت الشكل أو الجسم خوفاً من السرطان لأنه فيه
+
+682
+00:57:38,280 --> 00:57:44,780
+familial incidents بشكل قوي كتير، واضح؟
+
+683
+00:57:44,780 --> 00:57:47,980
+نعم، كنت أقول إن بقيت أملك الـ mastectomy جاب ما
+
+684
+00:57:47,980 --> 00:57:53,270
+يكون سرطانكنت بتبقى أعرف أن الـ «أندوطفرا» هذا كنت
+
+685
+00:57:53,270 --> 00:57:57,410
+تفيرة أو إستمال كبير من الـGangster Cancer أه لأ،
+
+686
+00:57:57,410 --> 00:58:02,190
+بالذات الأنواع الـFamilial هي الطفرة موجودة
+
+687
+00:58:02,190 --> 00:58:07,570
+بالعائلة كلها، ماشي، في تفاوت أحيانًا very
+
+688
+00:58:07,570 --> 00:58:10,610
+aggressive أحيانًا very late، حسب إذا في أشياء
+
+689
+00:58:10,610 --> 00:58:16,110
+تانية، بس النقطة كمان اتذكر أنهمش بس واحدة كافية
+
+690
+00:58:16,110 --> 00:58:19,750
+حتى يتكون سرطان لازم يكون أكتر من محله وأكتر من
+
+691
+00:58:19,750 --> 00:58:24,550
+مكانه بس وجود إشي معين أحياناً إذا فيه سهولة أننا
+
+692
+00:58:24,550 --> 00:58:29,950
+ندرسها راح يكون very suggestive وممكن على ضوءها
+
+693
+00:58:29,950 --> 00:58:34,470
+الواحد يقرر يعمل إشي preventive يعني زي ما حكينا
+
+694
+00:58:34,470 --> 00:58:37,770
+عن هذه الممثلة، وشو عندنا؟ ناشي؟
+
+695
+00:58:40,910 --> 00:58:51,650
+الـ الـ فيه concept يعني أنا أظن كمان مهم بالنسبة
+
+696
+00:58:51,650 --> 00:58:56,790
+الـ Mendelian أو يعني الـ familial و الـ inherited
+
+697
+00:58:56,790 --> 00:59:03,330
+forms of tumors و cancer وأحياناً Sporadic المثال
+
+698
+00:59:03,330 --> 00:59:07,950
+يعني Retinoblastomas الـ Retinoblastomas أحياناً
+
+699
+00:59:07,950 --> 00:59:13,060
+بيكونفاميليا، يعني تلاقيه موجودة في العائلة،
+
+700
+00:59:13,060 --> 00:59:32,620
+وفـ’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’
+
+701
+00:59:35,280 --> 00:59:41,100
+بالنسبة لـ Mendelian type of inheritance بتكون الـ
+
+702
+00:59:41,100 --> 00:59:44,760
+suggestive أو الـ very clear single mutation
+
+703
+00:59:44,760 --> 00:59:49,280
+وبالتالي هنا مثلا autosomal dominant males و
+
+704
+00:59:49,280 --> 00:59:52,960
+females و كل ال generation مصابين فبالتالي هذه
+
+705
+00:59:52,960 --> 00:59:57,200
+autosomal dominant mutation
+
+706
+00:59:57,200 --> 01:00:04,980
+والنتيجة أن الـ tumors usually are multipleيعني في
+
+707
+01:00:04,980 --> 01:00:10,500
+حالة الـDNA repair برضه mutation بيكون فيه skin
+
+708
+01:00:10,500 --> 01:00:14,760
+cancer وبيكون muscle cancer وبيكون كده بتلاقي
+
+709
+01:00:14,760 --> 01:00:19,060
+الـTumor في أكثر من محل وتكون bilateral وتكون
+
+710
+01:00:19,060 --> 01:00:26,460
+early onset طبعاً إذا early onset وaffects life
+
+711
+01:00:26,460 --> 01:00:31,730
+بشكل واضحفي الغالب ما راح تقدر العائلة تكمل
+
+712
+01:00:31,730 --> 01:00:37,390
+ويتكونوا هيك يعني المصاب ما vintage يعني بس يعني
+
+713
+01:00:37,390 --> 01:00:42,510
+هاي الـ الـ الـ characteristics that tells you
+
+714
+01:00:42,510 --> 01:00:48,030
+that this mutation in the germ line أو in in يعني
+
+715
+01:00:48,030 --> 01:00:52,230
+is a Mendelian type of inheritance type of cancer
+
+716
+01:00:52,230 --> 01:00:58,660
+causation في الـ sporadicفي الغالب Single Tumors،
+
+717
+01:00:58,660 --> 01:01:03,280
+Unilateral، Later Onset ويكون Somatic Mutation
+
+718
+01:01:03,280 --> 01:01:08,280
+Multiple وبتيجي بعدين في الحياة لحيث إنه شخص واحد
+
+719
+01:01:08,280 --> 01:01:12,740
+هو المصاب والبقية مش مصابة فأحياناً بعض السرطانات
+
+720
+01:01:12,740 --> 01:01:17,740
+بتلاقيها إما Sporadic أو Familial أو Inherited
+
+721
+01:01:17,740 --> 01:01:22,660
+ويكون يعني اللي بدي استنتج الواحد من هذا الكلام
+
+722
+01:01:22,660 --> 01:01:28,240
+إنه في هذه الحالة المندليانالـ effect of that
+
+723
+01:01:28,240 --> 01:01:31,800
+single mutation is very powerful is much stronger
+
+724
+01:01:31,800 --> 01:01:38,420
+than المطلوب وبتكون هنا من الـ germline mutation
+
+725
+01:01:38,420 --> 01:01:42,660
+وهنا بدأنا بـ normal gene وصار عندي somatic
+
+726
+01:01:42,660 --> 01:01:46,880
+mutation بدأنا هنا germline mutation وادتني إشي
+
+727
+01:01:46,880 --> 01:01:53,120
+تاني صوتها بزيادة وخبصت المعضلةهدولة يعني برضه من
+
+728
+01:01:53,120 --> 01:01:59,720
+الطواهر اللي بتحدث وبتكون موجودة الـ two slides
+
+729
+01:01:59,720 --> 01:02:06,580
+هدولة بيعطونا فكرة وهو دليل على إنه السرطانات is
+
+730
+01:02:06,580 --> 01:02:15,560
+in part is familial أو is genetic فيه variation في
+
+731
+01:02:15,560 --> 01:02:24,970
+الـ riskعلى كل نوع من الحرارة في عائلة معينة يعني
+
+732
+01:02:24,970 --> 01:02:33,150
+هنا بالأول هنا one parent اللي affected ب certain
+
+733
+01:02:33,150 --> 01:02:39,030
+cancer يعني if one parent is affected مثلا cancer
+
+734
+01:02:39,030 --> 01:02:46,380
+of the testicles almost five timesالإنسان إذا واحد
+
+735
+01:02:46,380 --> 01:02:50,500
+أبوه صار عنده سرطان الخصية يصير هو عنده سرطان
+
+736
+01:02:50,500 --> 01:02:54,700
+الخصي كمان five times more than the average
+
+737
+01:02:54,700 --> 01:03:02,820
+population البقية برضه فيها نسبة أقل بالنسبة
+
+738
+01:03:02,820 --> 01:03:08,000
+إلى إذا فيه sibling يعني أخ أو أخت أقوى سرطان ممكن
+
+739
+01:03:08,000 --> 01:03:11,780
+الإنسان يصيبه
+
+740
+01:03:11,780 --> 01:03:17,010
+هو thyroid gland cancerيعني تقريبًا 15 مرة أكتر من
+
+741
+01:03:17,010 --> 01:03:22,210
+عادة اللي هو الـ Standardized Incidence Ratio ‏for
+
+742
+01:03:22,210 --> 01:03:29,450
+cancer فالفكرة إذا الإنسان عنده Relatives أو
+
+743
+01:03:29,450 --> 01:03:33,050
+Relatives with certain types of cancer you can
+
+744
+01:03:33,050 --> 01:03:37,590
+appreciate that they can have increased risk for
+
+745
+01:03:37,590 --> 01:03:40,850
+cancer and part of this is because of shared
+
+746
+01:03:40,850 --> 01:03:46,700
+genetics بس كمان بيظل عنديمبدأ إنه ممكن الـ
+
+747
+01:03:46,700 --> 01:03:48,180
+«إنكريزد ريسك» «إنكريزد ريسك» «إنكريزد ريسك»
+
+748
+01:03:48,180 --> 01:03:48,740
+«إنكريزد ريسك» «إنكريزد ريسك» «إنكريزد ريسك»
+
+749
+01:03:48,740 --> 01:03:49,500
+«إنكريزد ريسك» «إنكريزد ريسك» «إنكريزد ريسك»
+
+750
+01:03:49,500 --> 01:03:52,980
+«إنكريزد ريسك» «إنكريزد ريسك» «إنكريزد ريسك»
+
+751
+01:03:52,980 --> 01:03:53,880
+«إنكريزد ريسك» «إنكريزد ريسك» «إنكريزد ريسك»
+
+752
+01:03:53,880 --> 01:04:05,360
+«إنكريزد ريسك» «إنكريزد ريسك» «إنكريزد
+
+753
+01:04:05,360 --> 01:04:12,920
+ريسك
+
+754
+01:04:13,420 --> 01:04:20,600
+يعني يمكن تقريبًا أربعين أو خمسين سنة فيه بالذات
+
+755
+01:04:20,600 --> 01:04:26,360
+مرض أو سرطان الدم اللي هو «CML» اللي بيسموه
+
+756
+01:04:26,360 --> 01:04:32,520
+«Chronic Myeloid Leukemia» سرطان الدم من نوعي معين
+
+757
+01:04:32,520 --> 01:04:38,520
+وهو سرطان بطيء ومزمن فهو «Chronic Myeloid
+
+758
+01:04:38,520 --> 01:04:45,740
+Leukemia» «CML»لاحظنا فيهم هدولة كمثال على الـ
+
+759
+01:04:45,740 --> 01:04:51,980
+كمثال على الـ Genetic Anomaly أنه فيه عندهم إشي
+
+760
+01:04:51,980 --> 01:04:55,960
+اسمه Philadelphia chromosome بالذات هذا السرطان
+
+761
+01:04:55,960 --> 01:05:00,580
+يعني راح نتكلم عنه لأنه فيه أشياء specific إله
+
+762
+01:05:00,580 --> 01:05:15,710
+أكتر يعني محددة أكتر وبتكون يعنياللي بتكون ال ..
+
+763
+01:05:15,710 --> 01:05:21,790
+يعني راح نحكي له عن نوع من العلاج له نتيجة فهمنا
+
+764
+01:05:21,790 --> 01:05:29,870
+للـ Pathogenesis تبع الـ Disease فيه
+
+765
+01:05:29,870 --> 01:05:37,520
+Two Genesواحد اسمه الـ B-cell receptor اللي هو PCR
+
+766
+01:05:37,520 --> 01:05:40,940
+يعني الـ Associated Protein with the B-cell
+
+767
+01:05:40,940 --> 01:05:43,460
+receptor اللي تبع الـ Immunoglobulin بس هو مش الـ
+
+768
+01:05:43,460 --> 01:05:49,000
+Immunoglobulin هو أنا في إيش ذبوب PCR فالـ PCR هذا
+
+769
+01:05:49,000 --> 01:05:55,560
+موجود على كرمزوم 22 وفي another gene برضه related
+
+770
+01:05:55,560 --> 01:06:03,170
+to theالـ Hematologic Series أو الـ Blood Cell الـ
+
+771
+01:06:03,170 --> 01:06:10,550
+White وحتى الـ Red Blood Cell على كرومزوم 9 اسمه
+
+772
+01:06:10,550 --> 01:06:15,430
+ABL-1 فالذين
+
+773
+01:06:15,430 --> 01:06:19,970
+لاحظوا من الأول وحتى قبل ما يفهموا ليش الأمر بتم
+
+774
+01:06:19,970 --> 01:06:27,340
+في الـCML بهذا الشكلإنه لدي لقوا Translocation
+
+775
+01:06:27,340 --> 01:06:36,640
+يعني فيه segment من كروموزوم 22 هذه الـ long arm
+
+776
+01:06:36,640 --> 01:06:43,820
+انتحار بتيجي وبتشبك على كروموزوم 9 قريبة بين هذه
+
+777
+01:06:43,820 --> 01:06:47,580
+بحيث اللي لقوا إن اللي عندهم هذا النوع من السرطان
+
+778
+01:06:47,580 --> 01:06:55,100
+الـ mutation عندهم إنه بيصير عندي Translocationزي
+
+779
+01:06:55,100 --> 01:07:00,600
+الـ Chromosome 22 على الـ Chromosome 9 وبتصير عندي
+
+780
+01:07:00,600 --> 01:07:10,720
+بيقرب الـ VCR على الـ AVL1 فالـ VCR AVL1 هو
+
+781
+01:07:10,720 --> 01:07:16,820
+البروتين الجديد الـ Product تبعه ولأنه دخل بالـ
+
+782
+01:07:16,820 --> 01:07:21,900
+VCR يعني بالـ B Cell Surface Receptor بيخلّي أنه
+
+783
+01:07:21,900 --> 01:07:28,480
+بيخرّبالخلايا الدم بحيث إنه بيكون نوع من السلطنات
+
+784
+01:07:28,480 --> 01:07:33,380
+محدد أو بشكل معين، اسمه الـCML ويكون عندي
+
+785
+01:07:33,380 --> 01:07:37,780
+Translocation بين أدولة الـTwo Points والنتيجة إن
+
+786
+01:07:37,780 --> 01:07:45,720
+الـABL1 جين والبروتين تبعه يصير يشبك مع الـPCR
+
+787
+01:07:48,160 --> 01:07:53,660
+جين وبروتين حيث تصير عندك نوتاتجين أو نوتاتج
+
+788
+01:07:53,660 --> 01:07:57,980
+بروتين بتطلع وهو اللي بيظن إنه بيخلّي الخلايا ما
+
+789
+01:07:57,980 --> 01:08:02,720
+تموت وبيخلّي السرطان يتشوّر فهذا هو
+
+790
+01:08:02,720 --> 01:08:08,140
+الـPhiladelphia Chromosome هو لـ«ماليقننسية
+
+791
+01:08:08,140 --> 01:08:12,540
+كينيطولوجية» من نوع معين أحياناً حتى بيساعدنا إنه
+
+792
+01:08:12,540 --> 01:08:18,900
+نتشخّص شو نوعية الخلية اللي عاملة المشكلةوفي عندها
+
+793
+01:08:18,900 --> 01:08:22,820
+هذه الاشياء وهذه كمان ملاحظة في كتير من الـ
+
+794
+01:08:22,820 --> 01:08:27,640
+hematologic malignancies أحنا هاي البركة الليمبومة
+
+795
+01:08:27,640 --> 01:08:31,280
+acute lymphoplastic leukemia acute lymphoplasty
+
+796
+01:08:31,280 --> 01:08:36,640
+اللي فيه more than for acute lymphoplastic acute
+
+797
+01:08:36,640 --> 01:08:42,120
+promyelocytic اللي قابلني ALL7A3
+
+798
+01:08:42,120 --> 01:08:46,640
+لـpromyelocytic أو chronic lymphocytic leukemiaأو
+
+799
+01:08:46,640 --> 01:08:50,360
+Follicular lymphoma أو Burkitt lymphoma طبعاً يعني
+
+800
+01:08:50,360 --> 01:08:53,580
+المبدأ
+
+801
+01:08:53,580 --> 01:08:57,860
+الأساسي يجب أن تتذكروا كلمة leukemia يعني سرطان في
+
+802
+01:08:57,860 --> 01:09:02,700
+الدم لما نفس الخلايا بتكون لسه بالـ lymph node
+
+803
+01:09:02,700 --> 01:09:07,840
+وموصة الدم نسميها lymphoma ففي Burkitt، Hodgkin،
+
+804
+01:09:07,840 --> 01:09:11,220
+Non-Hodgkin الـBurkitt هو من نوع من الـNon-Hodgkin
+
+805
+01:09:11,220 --> 01:09:15,630
+lymphoma فسهم كلهم نفس الخلاياودولة بيكون عندي
+
+806
+01:09:15,630 --> 01:09:23,030
+Translocation وفي تفاوت بالـ percentages الـ cases
+
+807
+01:09:23,030 --> 01:09:29,670
+و الـ affected proto-oncogene affected الـ PCR
+
+808
+01:09:29,670 --> 01:09:33,150
+ABL1 اللي هو الفلادلفيا البروميزوم وموجود في أكتر
+
+809
+01:09:33,150 --> 01:09:40,730
+منها اللي بدي أكم تتذكرون منه هو تبع الـ CML هذا
+
+810
+01:09:40,730 --> 01:09:50,000
+موجود 95% منالـ «CML» وبكون بالشكل اللي حكيناه
+
+811
+01:09:50,000 --> 01:09:53,300
+طبعاً يعني كمان النقطة التانية اللي واحد ينتبه
+
+812
+01:09:53,300 --> 01:09:59,600
+إلها لما هم يرسميكم إياها هنا إنه «Which test I
+
+813
+01:09:59,600 --> 01:10:04,300
+should use to diagnose this translocation»
+
+814
+01:10:04,300 --> 01:10:07,500
+«translocation» يعني قطعة كبيرة أحنا ما بنتكلم عن
+
+815
+01:10:07,500 --> 01:10:11,530
+الـ mutation زي single nucleotide polymorphismالـ
+
+816
+01:10:11,530 --> 01:10:15,050
+«سنب» أو الـ «مايكروسيتالايت» أو الأشياء الصغيرة
+
+817
+01:10:15,050 --> 01:10:19,790
+هذه قطعة، شنقة كويسة، كبيرة فبالتالي أنا لازم أعمل
+
+818
+01:10:19,790 --> 01:10:24,510
+«Caryotype» هنا بنعمل الـ «Chromosome
+
+819
+01:10:24,510 --> 01:10:29,230
+Translocation» نعملها Translocation حتى نفحصها
+
+820
+01:10:29,230 --> 01:10:33,890
+نفحص من خلال الـ «Caryotype» وبلاغي هذه الأنواع
+
+821
+01:10:33,890 --> 01:10:39,030
+نتذكر الـ «CML» والفرديل فيها Chromosome اللي
+
+822
+01:10:39,030 --> 01:10:48,530
+بيصير عنديTranslocation بين كرمزوم 9 و22 بالـ9،
+
+823
+01:10:48,530 --> 01:10:55,790
+الـQ هو 34 وبالـ22، الـQ هو 11 الـSegment بتبعات
+
+824
+01:10:55,790 --> 01:11:02,030
+الـDNA أو بتبعات الكرمزوم حتى يصير هذه المشكلة
+
+825
+01:11:02,030 --> 01:11:10,290
+وافتشفنا بعدين إن الـPCR-ABL-1 Joining هو اللي له
+
+826
+01:11:10,290 --> 01:11:16,980
+مشكلةوبعمل المشكلة باقية الأشياء ما تحصلوا آخر
+
+827
+01:11:16,980 --> 01:11:30,440
+سلايدين يعني بتكلم عن أو آخر موضوعين بدنا
+
+828
+01:11:30,440 --> 01:11:37,880
+نحاول نفهم كيف باكتشف أنه جين هو اللي عمل المشكلة
+
+829
+01:11:37,880 --> 01:11:47,210
+الموضوع هذابكون من خلال دراسة عدد كبير من الجينات
+
+830
+01:11:47,210 --> 01:11:54,830
+والدراسة ممكن يكون لها أكتر من طريقة الـSNP
+
+831
+01:11:54,830 --> 01:12:01,190
+والـSequencing بالـPCR وغيره بكون من خلال
+
+832
+01:12:01,190 --> 01:12:07,670
+Sequencing وأقرأ الـNucleotides وأحاول أشوف
+
+833
+01:12:07,670 --> 01:12:12,580
+الـVariation فيها أحيانًافي الطريقة الثانية حتى
+
+834
+01:12:12,580 --> 01:12:21,080
+أستنتج إن صار في خلل الجين إن أشوف أنه جينات صار
+
+835
+01:12:21,080 --> 01:12:24,660
+إلها activation أكتر وأنه جينات صار إلها
+
+836
+01:12:24,660 --> 01:12:29,220
+activation أقل يعني أنا بدرسها بطريقة مختلفة أنا
+
+837
+01:12:29,220 --> 01:12:35,600
+هنا ما بدرس نفس تركيب الـCoding Gene وشو هو فيه
+
+838
+01:12:35,600 --> 01:12:40,710
+مشكلة أنا بحاول أدرس كامهذا الـ gene اشتغل وكم
+
+839
+01:12:40,710 --> 01:12:48,270
+النسخ تبعته فالـ الـ الـ الـ حتى ينجح بهذا الأمر
+
+840
+01:12:48,270 --> 01:12:55,990
+أول شيء لازم يكون عندي good sample from يعني
+
+841
+01:12:55,990 --> 01:13:01,950
+controls and affected people يعني في الغالب هذه
+
+842
+01:13:01,950 --> 01:13:06,590
+الشيء بقدر أتحثها على عائلة عندي مجموعة أفراد فيها
+
+843
+01:13:07,040 --> 01:13:11,020
+زي مثلًا حكينا ثمين للـ Retinoplastoma أو لا إشي
+
+844
+01:13:11,020 --> 01:13:16,300
+أو أنا أجيب مجموعة مصابين بسرطان معين مثلًا
+
+845
+01:13:16,300 --> 01:13:20,940
+Thyroid Cancer أو CML أو أي نوع Cancer وأجيب
+
+846
+01:13:20,940 --> 01:13:25,180
+مجموعة مصابين وأكون أنا عارف الـStandard
+
+847
+01:13:27,610 --> 01:13:35,170
+شو اسمه؟ عارف الـ Standard Result تبع الفشر
+
+848
+01:13:35,170 --> 01:13:40,230
+العاديين مجموعة أخرى طبيعية مش مصابية طريقة
+
+849
+01:13:40,230 --> 01:13:45,610
+الدراسة هنا اللي بيسموها Expression Profiling يعني
+
+850
+01:13:45,610 --> 01:13:52,810
+بالأخير أنا بقيس كام نسخ الـ RNA على مستوى الـ RNA
+
+851
+01:13:52,810 --> 01:14:00,830
+أحياناًأو مستوى البروتين كده اندي بروتين ناتج في
+
+852
+01:14:00,830 --> 01:14:08,770
+هذه الخلايا تبع هذه المجموعة وهذه المجموعة طريقة
+
+853
+01:14:08,770 --> 01:14:17,350
+القراءة، فانت هنا الجهاز هذا، الدراسة هذه في هذه
+
+854
+01:14:17,350 --> 01:14:22,710
+الـStudies Specifically درسوا عن حوالي 100 جيون
+
+855
+01:14:23,590 --> 01:14:31,970
+طبعًا هذه الصفات اللي يعني نعتبرها الـ «جديدة
+
+856
+01:14:31,970 --> 01:14:38,290
+التكنولوجيا» لتعمل الدراسات اللي هي إنه أنا عند
+
+857
+01:14:38,290 --> 01:14:42,070
+الآلة قوي جدًا زي كمبيوتر سريق جدًا زي جوجل هيك،
+
+858
+01:14:42,070 --> 01:14:47,770
+بتحطله كلمتين بتجيبك البحث خلال واحد بالمئة من
+
+859
+01:14:47,770 --> 01:14:54,310
+التاني وكذا فهي أدوات قوية جدًاوهنا أنا بفحص سواء
+
+860
+01:14:54,310 --> 01:14:58,290
+على مستوى الـ RNA أو البروتين على الـ Gene
+
+861
+01:14:58,290 --> 01:15:04,170
+Expression فأنا هنا أخدت 100 جين بحاول أدرسهم
+
+862
+01:15:04,170 --> 01:15:10,530
+وأشوف درجة الـ Expression تبعت الجين هذا الـ
+
+863
+01:15:10,530 --> 01:15:15,670
+Expression تبعه بدي تكون RNA أو بروتين بالأخير راح
+
+864
+01:15:15,670 --> 01:15:21,430
+أحصل for individual sample نقط بدي تكون بهذا الشكل
+
+865
+01:15:22,110 --> 01:15:27,770
+لما يكون أصفر معناته هذا الـ gene الـ expression
+
+866
+01:15:27,770 --> 01:15:33,610
+تبعه زيه زي الـ normal person إذا حاطين أخضر أحمر
+
+867
+01:15:33,610 --> 01:15:39,850
+بالأول معناته إنه هذا الـ expression تبعه قلب بطل
+
+868
+01:15:39,850 --> 01:15:45,790
+يكون منه وبالنسبة لأخضر معناته الـ expression
+
+869
+01:15:45,790 --> 01:15:52,010
+level أكبر فهنا زي ما هم حاطينك هناto a reference
+
+870
+01:15:52,010 --> 01:15:58,610
+expression profile طبعاً يعني لو أنا جيت بدي أشوف
+
+871
+01:15:58,610 --> 01:16:04,130
+مثل هذه الأشياء ممكن لو أخد لنفس الإنسان وهيسووها
+
+872
+01:16:04,130 --> 01:16:08,970
+لنفس الإنسان tissues from different sites أو
+
+873
+01:16:08,970 --> 01:16:12,800
+organsأنا باخده من العضلات شوية من الجلد شوية من
+
+874
+01:16:12,800 --> 01:16:18,160
+الدم شوية من الـ GI tract من كده من كده و أشوف أيش
+
+875
+01:16:18,160 --> 01:16:21,060
+الدينات اللي بتشتغل أكتر و أيش الدينات اللي بتبطل
+
+876
+01:16:21,060 --> 01:16:27,220
+أكتر فأنا عندي ثماني individuals بصفهم بهذا الشكل
+
+877
+01:16:27,220 --> 01:16:32,380
+يعني أنا الـresult لكل واحد بتكون بهذا الشكل و
+
+878
+01:16:32,380 --> 01:16:38,040
+بعدين بصفهم هنا ثمان أفراد بالـMeat Gene اللي أنا
+
+879
+01:16:38,040 --> 01:16:45,510
+درستهموبعدين أنا بقسم بعدين النتائج ليعني بالأخير
+
+880
+01:16:45,510 --> 01:16:54,050
+بهمني شو المجموعة اللي مجموعة الجينات اللي يعني
+
+881
+01:16:54,050 --> 01:16:58,830
+صار لها over expression ومجموعة الجينات اللي صار
+
+882
+01:16:58,830 --> 01:17:04,430
+لها under expression فهنا كمثال يعني hypothetical
+
+883
+01:17:04,430 --> 01:17:11,250
+افتراضيإنه أنا بس جيت درست الموضوع هذا كان عندي
+
+884
+01:17:11,250 --> 01:17:15,690
+مثلا tumor A من المجموعة الـ Individual اللي عندهم
+
+885
+01:17:15,690 --> 01:17:19,490
+كان tumor A و tumor B وقارنت بينهم أو ممكن حطوا
+
+886
+01:17:19,490 --> 01:17:22,890
+طبعاً بالأول بيكونوا حاطين الـ Background أو الأصل
+
+887
+01:17:22,890 --> 01:17:29,190
+اللي هو الـ Normal فأنا راح ألاقي إنه المجموعة هذه
+
+888
+01:17:29,190 --> 01:17:33,930
+certain genes هذه بالزاوية هذه بيكون much higher
+
+889
+01:17:33,930 --> 01:17:41,710
+in A than in Bويعني هنا دول المجموعة الـA
+
+890
+01:17:41,710 --> 01:17:46,270
+الـExpression تبعهم أخضر لهذه الجينات جين 1، جين
+
+891
+01:17:46,270 --> 01:17:53,310
+25 و27 بحدد أي جينات اللي هنا وهنا أقل مجموعة
+
+892
+01:17:53,310 --> 01:17:58,090
+بالنسبة للـTumor B أقل من إتريا هنا بتصير قل
+
+893
+01:17:58,090 --> 01:18:03,870
+وبعدين هنا مجموعة الجينات هذه شغالة أكتر كثير عند
+
+894
+01:18:03,870 --> 01:18:09,430
+اللي عندهم Type B tumorوأكتر من الـ Type A الجينات
+
+895
+01:18:09,430 --> 01:18:13,990
+هذه بشوف درجة اللي لو كان عندي عدد بشوف قوة
+
+896
+01:18:13,990 --> 01:18:18,410
+الارتباط بين expression over expression أو under
+
+897
+01:18:18,410 --> 01:18:21,310
+expression of certain gene to any type of cancer
+
+898
+01:18:21,310 --> 01:18:26,250
+هدولة يعني من الدراسات اللي ممكن تعمل تعتمد على
+
+899
+01:18:26,250 --> 01:18:31,830
+تقنيات حديثة تعتمد على إنه أنا أجيب عينات مناسبة
+
+900
+01:18:32,390 --> 01:18:36,650
+أقدر أقارن بينهم سواء الـ «تجارب مختلفة» «تجارب
+
+901
+01:18:36,650 --> 01:18:41,390
+مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب
+
+902
+01:18:41,390 --> 01:18:43,570
+مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب
+
+903
+01:18:43,570 --> 01:18:43,590
+مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب
+
+904
+01:18:43,590 --> 01:18:43,750
+مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب
+
+905
+01:18:43,750 --> 01:18:44,010
+مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب
+
+906
+01:18:44,010 --> 01:18:44,770
+مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب
+
+907
+01:18:44,770 --> 01:18:44,770
+مختلفة» «تجارب مختلفة»
+
+908
+01:18:58,620 --> 01:19:03,060
+واللي مثلًا كله أصفر بالباقية معناته لأ ما كان إله
+
+909
+01:19:03,060 --> 01:19:08,260
+دخله ما إله كان إله دور يعني هاي الأشياء بتكون
+
+910
+01:19:08,260 --> 01:19:16,280
+بأذا الشكل هنا بنفس الطريقة يعني هاي على نفس
+
+911
+01:19:16,280 --> 01:19:21,740
+المبدأ اللي شفناها قبل شوية
+
+912
+01:19:29,310 --> 01:19:35,570
+هذه الأنواع من الدراسات صراحة يعني معقدة جدا
+
+913
+01:19:35,570 --> 01:19:40,990
+وللأسف يعني أحياناً كتيرة حتى لو بحاول أقراها في
+
+914
+01:19:40,990 --> 01:19:46,150
+مجلات علمية وبحاول أرجع للـ Original Data مرات
+
+915
+01:19:46,150 --> 01:19:51,110
+كتير بتكون غير مفهومة بشكل قوي وبالتالي يعني
+
+916
+01:19:51,110 --> 01:19:58,250
+بتخربط الواحد اللي بدهم يحكوه هناإنه حتى يثبتوا
+
+917
+01:19:58,250 --> 01:20:06,490
+إنه والله الجين الإفلاني هو المهم وهو اللي يعني
+
+918
+01:20:06,490 --> 01:20:09,690
+اللي
+
+919
+01:20:09,690 --> 01:20:18,890
+له دور أكبر أحيانًا من يعني طريقة المتابعة للمرضى
+
+920
+01:20:21,460 --> 01:20:24,820
+إنه أنا أربط الموضوع هذا بالنسبة للـGene
+
+921
+01:20:24,820 --> 01:20:32,140
+Expression مع الـSurvivor يعني أنا عندي الآن مثلا
+
+922
+01:20:32,140 --> 01:20:38,720
+ميت مريض lung cancer نفترض هيك وأخدت بالـDiagnosis
+
+923
+01:20:38,720 --> 01:20:44,820
+lung cancer وجيت بعدين عملت نوع من الدراسة زي هذه
+
+924
+01:20:45,490 --> 01:20:51,670
+بتورت أشوف اجدرت بطريقة معينة أنه أخليهم cluster
+
+925
+01:20:51,670 --> 01:21:00,850
+يعني يكون مجموعة يعني ممكن نوعية معينة مثلا إشي
+
+926
+01:21:00,850 --> 01:21:05,070
+مميز لها فأهمية
+
+927
+01:21:05,070 --> 01:21:10,310
+الـ Gene بالذات على الـ pathogenesis على الـ
+
+928
+01:21:10,310 --> 01:21:15,390
+Prognosis على إذا أحيانًا Treatment Modalityإنه
+
+929
+01:21:15,390 --> 01:21:20,490
+أنا يعني هنا نوع دراسي تاني مختلفة إنه بعد ما عرفت
+
+930
+01:21:20,490 --> 01:21:25,690
+إنه أنا قسمت الخلايا أو قسمت الـ Sample إنه هدولة
+
+931
+01:21:25,690 --> 01:21:30,210
+مجموعة عندهم certain genes هم اللي مش شغلات و
+
+932
+01:21:30,210 --> 01:21:33,070
+certain genes هم الشغلات على العكس الـCluster B
+
+933
+01:21:33,820 --> 01:21:40,060
+بلاقي إنه بعدين تابعت المرضى هذولة وخصوصاً هنا
+
+934
+01:21:40,060 --> 01:21:43,140
+الحالة بقاعي بالـ months على كلامهم يعني هنا
+
+935
+01:21:43,140 --> 01:21:47,360
+تابعوا المرضى عشر سنين زي الـCML أو الـprostate
+
+936
+01:21:47,360 --> 01:21:51,960
+cancer هذولة cancer ولو إنهم cancer بس بطيل وبعض
+
+937
+01:21:51,960 --> 01:21:56,100
+أنواع السرطانات هيك فنتج عن الأمر هذا إنه أنا
+
+938
+01:21:56,100 --> 01:22:01,400
+لاحظتإن اللي عندهم بهذا الشكل لأ والله شغلهم أحسن
+
+939
+01:22:01,400 --> 01:22:05,580
+يعني أنا هنا ما بكون aggressive ما بكون هذا هذا
+
+940
+01:22:05,580 --> 01:22:10,440
+المريض بروستيت كانسر والله مرات كتير بحكي و بقول
+
+941
+01:22:10,440 --> 01:22:14,580
+الأهل المرضى هو مرضى إذ ذات كبير بالعمر و عنده
+
+942
+01:22:14,580 --> 01:22:19,860
+نوعية بطيقة بقوله يمكن لو علجناه نذبحه أسرع نقتل
+
+943
+01:22:19,860 --> 01:22:27,340
+المريض أسرع من إنسان تركناه لحالهفهنا بثبتوا إنها
+
+944
+01:22:27,340 --> 01:22:34,340
+Two clusters by the gene expression واستفدت منها
+
+945
+01:22:34,340 --> 01:22:38,480
+إنه اللي عنده الـCluster A لازم يكون Aggressive
+
+946
+01:22:38,480 --> 01:22:42,740
+لأن هذا الإنسان راح يكون الـPrognosis تبعه Bad،
+
+947
+01:22:42,740 --> 01:22:46,460
+Poor، على العكس لو كان على الـCluster B وهي فائدة
+
+948
+01:22:46,460 --> 01:22:49,960
+لهذا النوع من الدراسات الـLong Term Survival
+
+949
+01:22:49,960 --> 01:22:57,730
+النقطة الأخيرةإنه يعني حتى في مفهوم قضية إن كل
+
+950
+01:22:57,730 --> 01:23:01,510
+خلية لازم يكون لها كل نوع من الخلايا لازم يكون لها
+
+951
+01:23:01,510 --> 01:23:05,430
+نوع معدد من الـ Transcription Factor من Certain
+
+952
+01:23:05,430 --> 01:23:12,370
+Signals Signal Transduction فهذه أنتجت إنه صار
+
+953
+01:23:12,370 --> 01:23:17,210
+عندي أنواع كتير من الأدوية اللي بتحاول تخرّب أو
+
+954
+01:23:17,210 --> 01:23:25,940
+تنشط مرات Certain Signal Transductionفهدولة يعني
+
+955
+01:23:25,940 --> 01:23:30,140
+نسميهم «Tyrosine Kinase Inhibitor» أحيانًا
+
+956
+01:23:30,140 --> 01:23:36,620
+«Activator» بس يعني «Tyrosine Kinase» يعني
+
+957
+01:23:36,620 --> 01:23:46,120
+«Inhibitor» أو أحيانًا «Modifier» أو كده ففيه
+
+958
+01:23:46,120 --> 01:23:49,580
+الآن طالع عندي مجموعة «Cancer Treatments Targeted
+
+959
+01:23:49,580 --> 01:23:53,140
+to Specific Activated Driver Oncogenes»
+
+960
+01:23:56,310 --> 01:24:04,410
+الأدوية اسمها كتير فإحنا بس بدي منكم اثنين الـ
+
+961
+01:24:04,410 --> 01:24:14,350
+Imatinib اللي هو نسيت اسمه نسيت Imatinib في لسن
+
+962
+01:24:14,350 --> 01:24:21,870
+تجاري مشهور جدا بس راح انبالي هذا عبارة عن يعني
+
+963
+01:24:21,870 --> 01:24:27,350
+بالذات للـ CMLيعني قريب بدخل في زي ما حكينا
+
+964
+01:24:27,350 --> 01:24:35,850
+الفلاجينفيا chromosome هذا عبارة عن يعني drug very
+
+965
+01:24:35,850 --> 01:24:43,850
+specific to the myeloid series ونتيجته إنه كأنه
+
+966
+01:24:43,850 --> 01:24:49,170
+الـ Apoptosis تبع الخلايا بوقّط الـCMLهو بتجبر
+
+967
+01:24:49,170 --> 01:24:54,570
+الخلايا تظل تنقسم وتكمل هو Specific Inhibitor of
+
+968
+01:24:54,570 --> 01:25:00,550
+Tyrosine Kinase الـNIP إذا بتنتبهوا عليها بالأخير
+
+969
+01:25:00,550 --> 01:25:07,710
+هاي اللي هما الأسماء تبعات الـInhibitors of
+
+970
+01:25:07,710 --> 01:25:13,530
+Tyrosine Kinase الـNIPS دولة فـGifety-NIP، Matty
+
+971
+01:25:13,530 --> 01:25:17,810
+-NIP، Milton-NIP ومش عارف دستاني-NIPالذول إذا
+
+972
+01:25:17,810 --> 01:25:22,250
+بتشوف إشي زي هيك اسمه بالأخير هذا Inhibitor of a
+
+973
+01:25:22,250 --> 01:25:26,970
+Certain Tyrosine Kinase وبصير يعني نتيجة بدأ الأمر
+
+974
+01:25:26,970 --> 01:25:30,950
+إنه أنا أول شي درست الـGene ودرست الـ… هو
+
+975
+01:25:30,950 --> 01:25:34,890
+الـOncogene أو Driver Oncogene وشبت الـSignal
+
+976
+01:25:34,890 --> 01:25:39,450
+Transaction تبعه أنه Tyrosine Kinase صرت أجيب أدوي
+
+977
+01:25:39,450 --> 01:25:43,030
+ومركبات وأشياء أشوف مين اللي بيطبط هذا الـTyrosine
+
+978
+01:25:43,030 --> 01:25:48,660
+Kinase وطلعوا مجموعة أدوي كبيرةفهذه الآن يعني هي
+
+979
+01:25:48,660 --> 01:25:54,040
+دراسة Targeted وهدولة كلهم من شركات أجرت دراسات
+
+980
+01:25:54,040 --> 01:25:59,640
+على السرطانات بهذا الشكل بتأخذ السرطان، بتعزل الـ
+
+981
+01:25:59,640 --> 01:26:04,360
+Thyrosinkinase تبعه بتحاول أن تتألف دواء ضد الـ
+
+982
+01:26:04,360 --> 01:26:09,380
+Thyrosinkinase فهذا مجموعة أدوية في أشياء كتيرة
+
+983
+01:26:09,380 --> 01:26:15,970
+أنا بس بطلب منكم الـ Imatinibاللي هو بالـ CML لأنه
+
+984
+01:26:15,970 --> 01:26:20,210
+فقعات جداً وكويس والـ side effects تبعه قليل يعني
+
+985
+01:26:20,210 --> 01:26:24,070
+إله major side effects بس نسبياً مش جد الكيموتراب
+
+986
+01:26:24,070 --> 01:26:28,290
+التاني و ال .. و ال .. يعني و الـ much better
+
+987
+01:26:28,290 --> 01:26:35,270
+tolerated أحسن الجروب التانية اللي هي بالأخير MAP
+
+988
+01:26:35,270 --> 01:26:42,830
+مثلًا Mplexigmap وغيرها اللي هو Trajectomapاللي هو
+
+989
+01:26:42,830 --> 01:26:50,150
+Amplified HER2-Gene في الـ Breast Cancer فالـ
+
+990
+01:26:50,150 --> 01:26:53,450
+Breast Cancer، الآن إحنا عندنا حتى في مستشفى الملك
+
+991
+01:26:53,450 --> 01:26:58,390
+المؤسس أي إمرأة أو إنسان، حتى ما يمكن نصيب الذكور
+
+992
+01:26:58,390 --> 01:27:04,390
+الـ Breast Cancer بإذا في حالة عندي HER2-Receptor
+
+993
+01:27:04,390 --> 01:27:09,630
+Positive نعطيه هذا الدواء، طبعا مشكلته الأنبول
+
+994
+01:27:09,630 --> 01:27:13,620
+الواحدة يبدو المريض مثلافي كل جرعة، انبولتين،
+
+995
+01:27:13,620 --> 01:27:19,380
+تلاتي، أربعة أحياناً بالألاف يعني all these drugs
+
+996
+01:27:19,380 --> 01:27:24,380
+are very extensive، very recent وفي شغل كتير عليهم
+
+997
+01:27:24,380 --> 01:27:30,000
+الـMAPS اللي هم الـMonoclonal Antibody ناشي، ويله
+
+998
+01:27:30,000 --> 01:27:33,920
+أنواعه المفروض تكونوا تعرفوا عنه من الـImmunology
+
+999
+01:27:33,920 --> 01:27:37,540
+في أحد عنده أسئلة؟ أي آخر slide؟
+
+1000
+01:27:42,970 --> 01:27:47,890
+الله يعطيكم العافية وإن شاء الله إذا في أسئلة
+
+1001
+01:27:47,890 --> 01:27:52,750
+للأسبوع القادم وبنكمل إن شاء الله الله يعطيكم
+
+1002
+01:27:52,750 --> 01:27:57,370
+العافية ويذريكم الخير ونشوفكم الأسبوع اللي جاي
+
+1003
+01:27:57,370 --> 01:28:01,390
+يعطيك ألف عافية دكتور الله يرضى عليك الله حييك
+
+1004
+01:28:01,390 --> 01:28:03,950
+الله يكرمك سلام عليك برعاية الله
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/K4hCcRDLuUY.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/K4hCcRDLuUY.srt
new file mode 100644
index 0000000000000000000000000000000000000000..1b01e364643a2ce65fcec0afbd3a2ed71092d9a9
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/K4hCcRDLuUY.srt
@@ -0,0 +1,3109 @@
+1
+00:00:00,000 --> 00:00:08,880
+بحب إنه الواحد مننا يكون بهذه الصورة كاملة وهكذا
+
+2
+00:00:08,880 --> 00:00:13,120
+يحاول يفهم إحنا بنحاول ماذا نقول أو ماذا ندرس أو ماذا
+
+3
+00:00:13,120 --> 00:00:16,980
+نتعامل الآن
+
+4
+00:00:16,980 --> 00:00:23,480
+الوراثة تعتمد على أن الـDNA الذي تكلمنا عنه الذي
+
+5
+00:00:23,480 --> 00:00:29,450
+هو أساس في تكون البروتين وهو المسؤول عن تكوين
+
+6
+00:00:29,450 --> 00:00:38,290
+البروتينات وهو موجود بشكل متساوي في الغالب، يعني كل
+
+7
+00:00:38,290 --> 00:00:45,230
+الخلايا، ما عدا الخلايا الجنسية، ويكون الخلايا
+
+8
+00:00:45,230 --> 00:00:52,350
+تقوم بطريقة دقيقة جداً بعملية تكرار الـDNA حيث
+
+9
+00:00:52,350 --> 00:00:57,670
+أنه دائماً الـDNA تبع كل الخلايا الأصلي يقول
+
+10
+00:00:57,670 --> 00:01:07,450
+"كله متشابه"، بعدين يعني اتكلمنا عن أنه عندنا يعني
+
+11
+00:01:07,450 --> 00:01:12,390
+هكذا كمبدأ، أريد الواحد هكذا يتذكر، وبعدين قضية أنه
+
+12
+00:01:12,390 --> 00:01:18,290
+إحنا تقريباً كأنواع، نُعرّف ونُحدد بتفصيل في الوراثة
+
+13
+00:01:18,290 --> 00:01:24,990
+نتكلم على ثلاثة أنواع في حالات أو أمراض نتيجة تخلف
+
+14
+00:01:24,990 --> 00:01:29,090
+في الكروموزوم كله، فالـChromosomal Diseases هذه
+
+15
+00:01:29,090 --> 00:01:33,370
+عادةً كبيرة جداً، واللي هي مشاكل كثيرة، مثل الـDown
+
+16
+00:01:33,370 --> 00:01:39,910
+Syndrome، وفي Mendelian Diseases اللي هي بيقول فقط
+
+17
+00:01:39,910 --> 00:01:44,890
+جين واحد هو المسؤول عن المرض، وفي علاقة بينهم
+
+18
+00:01:44,890 --> 00:01:49,910
+وفي لها أمثلة، والشغل الثالث اللي هو الغالبية العظمى
+
+19
+00:01:49,910 --> 00:01:53,170
+من كثير من الأمراض، مثل الضغط والسكر والربو
+
+20
+00:01:53,170 --> 00:02:00,050
+والأمراض الكثيرة، في حالات بيكون أنه يشترك عدد
+
+21
+00:02:00,050 --> 00:02:04,430
+كبير من الجينات فيها، بس مش كروموزوم، عدد كبير من
+
+22
+00:02:04,430 --> 00:02:14,470
+الجينات، النوع الثالث هذا مرتبط بآليات التحكم في
+
+23
+00:02:14,470 --> 00:02:21,680
+الـExpression للجين، يعني بدك تفهم إنك أنت الجين
+
+24
+00:02:21,680 --> 00:02:26,920
+الواحد مش شغال في كل الخلايا، الخلية التي تحتاج
+
+25
+00:02:26,920 --> 00:02:32,120
+هذا الجين، تشتغل هي الخلية التي راح تشغله، وأحياناً
+
+26
+00:02:32,120 --> 00:02:41,210
+كثيرة، يعني من الـ22000، 23000 جين موجودين، بيكون عدد
+
+27
+00:02:41,210 --> 00:02:46,310
+قليل من الجينات التي… يعني نسبة قليلة من الجينات
+
+28
+00:02:46,310 --> 00:02:53,570
+يتم تشغيلها، ف… آليات التحكم في أي من الجينات
+
+29
+00:02:53,570 --> 00:02:57,950
+يشتغل، وأيّ ما يشتغلش، ومتى يشتغل، ومتى ما يشتغلش،
+
+30
+00:02:57,950 --> 00:03:01,910
+هذه نسميها Epigenetic Mechanisms، التي هي
+
+31
+00:03:01,910 --> 00:03:09,740
+آليات التحكم في تنشيط أو تنويم الجينات، والفروقات
+
+32
+00:03:09,740 --> 00:03:15,320
+فيها، فهذه الظواهر التي نتكلم عنها كـEpigenetic
+
+33
+00:03:15,320 --> 00:03:22,800
+عملية التخليق كيف تتم، عمليات متعددة وكثيرة، وهي
+
+34
+00:03:22,800 --> 00:03:27,300
+يعني يعني
+
+35
+00:03:27,300 --> 00:03:33,520
+هي تقوم الآن، يعني يحاولون أنه من خلالها يعني
+
+36
+00:03:33,520 --> 00:03:39,620
+يفهموا كثيراً من الأمراض، بعض الأمراض، ويلاحظون أنه
+
+37
+00:03:39,620 --> 00:03:45,920
+ممكن نفهم منها أو من خلالها أيضاً، إلى الآن لم ينجحوا، بس
+
+38
+00:03:45,920 --> 00:03:53,480
+يتأملون أن يكونوا أدوية أو طرائق تعديل المرض من
+
+39
+00:03:53,480 --> 00:04:00,560
+خلال التدخل بطريقة مفيدة أو ضد المرض، في أنه ماذا
+
+40
+00:04:00,560 --> 00:04:04,830
+الذي نريد أن يعيش، يشتغل، وماذا الذي نريد أن يعيش، لا يشتغل، الآن
+
+41
+00:04:04,830 --> 00:04:11,050
+المحاضرة القادمة، الثالثة، هي تتكلم عن تركيب
+
+42
+00:04:11,050 --> 00:04:17,690
+الكروموزومات والجينات، وكيف هي موجودة على الـDNA في
+
+43
+00:04:17,690 --> 00:04:24,170
+وسط الخلية، المحاضرة التي بعدها، الثانية، راح نتكلم
+
+44
+00:04:24,170 --> 00:04:29,430
+كيف إحنا متنوعين، ما هي الاختلافات الموجودة بين
+
+45
+00:04:29,430 --> 00:04:38,020
+البشر عموماً، وبالتالي يعني محاولة شرح وجود تفاوت
+
+46
+00:04:38,020 --> 00:04:44,460
+بين البشر، أنه ليس فقط التفاوت هو نتيجة اختلاف الـ
+
+47
+00:04:44,460 --> 00:04:49,620
+DNA نفسه على مستوى الجينات نفسها، الـEpigenetic
+
+48
+00:04:49,620 --> 00:04:54,260
+Mechanisms أيضاً، لها دور في أن هذا
+
+49
+00:04:54,260 --> 00:04:59,000
+الإنسان يطلع شوية مختلف عن الإنسان، فهنا مثلاً مثال
+
+50
+00:04:59,000 --> 00:05:04,480
+أنه أنا الـ… بالـKaryotype طبعاً إذا أحد لا يفهم
+
+51
+00:05:04,480 --> 00:05:11,340
+ماذا يعني،  يا دكتور أحمد، أطلب من أي إنسان عنده أنا
+
+52
+00:05:11,340 --> 00:05:16,200
+لم أحط الـChat أو لم يظهر معه الـChat، إذا أردتم
+
+53
+00:05:16,200 --> 00:05:21,180
+أن أحطه، Show Video Grid، أو هكذا، إذا أحد يحب أن يسأل أو
+
+54
+00:05:21,180 --> 00:05:26,590
+على الـFacebook أو الـWhatsApp، يَسأل سؤالاً، أيضاً
+
+55
+00:05:26,590 --> 00:05:30,850
+يحدث، فإذا
+
+56
+00:05:30,850 --> 00:05:38,130
+أخذنا الآن، يعني لما إحنا نجي نقرأ الـ بدقة أكثر
+
+57
+00:05:38,130 --> 00:05:44,550
+تركيب الجين، وتركيب الـDNA أو الكروموزوم
+
+58
+00:05:44,550 --> 00:05:50,530
+الذي هو الكتلة الكبيرة، أجد أنني لما آتي أشوف
+
+59
+00:05:50,530 --> 00:05:55,630
+كروموزوم، مثل هنا Chromosome 11، كنا نحكي أنه فيه
+
+60
+00:05:55,630 --> 00:06:00,470
+Centromere، بالنص، عشان يعرف يتوجه للجهتين
+
+61
+00:06:00,470 --> 00:06:05,010
+المتضادتين في انقسام الخلية، وفي شيء مثل الـTelomere
+
+62
+00:06:05,010 --> 00:06:09,810
+الذي هو الشيء الطرفي الذي نهايته مسبحة، عشان
+
+63
+00:06:09,810 --> 00:06:16,570
+يتحكم في عدد مرات انقسام الخلايا، فإذا بأخذ أن
+
+64
+00:06:16,570 --> 00:06:22,050
+أنا جئت في لحظة معينة، الذي هو الـChromosome 11
+
+65
+00:06:23,210 --> 00:06:28,890
+المنطقة التي هي الخامسة
+
+66
+00:06:28,890 --> 00:06:34,070
+و فاصل الخمسة عشر إلى الخامسة و فاصل الخمسة و ثلاثين
+
+67
+00:06:34,070 --> 00:06:40,070
+يعني هنا هذه القطعة الصغيرة التي يسمونها الـP التي
+
+68
+00:06:40,070 --> 00:06:46,270
+هي P  للتحت، وبعدين الـQ الطويل، للتحت عادةً نبدأ من
+
+69
+00:06:46,270 --> 00:06:52,780
+فوق، ونمشي فيهما للتحت، فنلاحظ أنه في مناطق فيها كثيراً
+
+70
+00:06:52,780 --> 00:06:58,760
+جينات، وفيها طريقة أن الواحد يعرف أن هذا عبارة عن
+
+71
+00:06:58,760 --> 00:07:07,420
+جين، يعني قطعة الـDNA يتم قراءتها، يقدر كما ذكرت
+
+72
+00:07:07,420 --> 00:07:12,700
+المرة الفائتة، أنه حوالي 4% فقط من الـDNA في
+
+73
+00:07:12,700 --> 00:07:19,900
+الإنسان عبارة عن coding DNA، يعني عبارة عن شيء راح
+
+74
+00:07:19,900 --> 00:07:25,160
+يتم الاستفادة منه في عمل البروتين لاحقاً، والغالبية
+
+75
+00:07:25,160 --> 00:07:30,480
+العظمى من الـDNA عبارة عن الـNon-Coding DNA، يعني
+
+76
+00:07:30,480 --> 00:07:38,620
+فقط تكميلية، وحشوة، وشيء موجود بالنص، يعني يظن أن هذا
+
+77
+00:07:38,620 --> 00:07:43,100
+يساعد، لأنه حتى لو صار خلل في الـDNA، أنه يصير
+
+78
+00:07:43,100 --> 00:07:48,300
+احتمالية أكبر أن يكون الخلل في منطقة غير ضارة أو
+
+79
+00:07:48,300 --> 00:07:54,680
+غير مسببة لمرض، يعني هكذا يظن الآن، فلو جئنا نأخذ هذه
+
+80
+00:07:54,680 --> 00:07:58,300
+القطعة الصغيرة التي هي موجودة هنا بالـKaryotype
+
+81
+00:07:58,300 --> 00:08:03,900
+بشكل الـKaryotype لـChromosome 11، وأنا أكبرها
+
+82
+00:08:03,900 --> 00:08:09,140
+أكبر، إذا دخلت بتفاصيل أكثر، سأجد أن في حوالي
+
+83
+00:08:09,140 --> 00:08:12,780
+هنا، بعد ظني، قالوا عشر جينات موجودة في هذا
+
+84
+00:08:12,780 --> 00:08:19,520
+المكان، وفي الغالب نلاحظ أن في تقارب في وظائف هذه
+
+85
+00:08:19,520 --> 00:08:25,120
+الجينات، وفي الغالب هنا نتكلم عن شيء اسمه الـ
+
+86
+00:08:25,120 --> 00:08:29,620
+Olfactory Receptor Genes، وهذه خمسة بجانب بعض
+
+87
+00:08:29,620 --> 00:08:34,440
+وفي شيء الذي دخل بالـBeta Globulin Genes، وفي
+
+88
+00:08:34,440 --> 00:08:39,320
+خمسة منهم، ولما نجي نقرأه، نقرأ بهذا الشكل، ويكون
+
+89
+00:08:39,320 --> 00:08:48,100
+هكذا، فهذا تركيب الـDNA وتركيبه على مستوى أول شيء
+
+90
+00:08:48,100 --> 00:08:52,560
+على مستوى الكروموزوم، وعلى مستوى الـBands التابعة للـ
+
+91
+00:08:52,560 --> 00:09:01,120
+Chromosome، وعلى مستوى بعدين الذي نسميه القراءة
+
+92
+00:09:01,120 --> 00:09:04,200
+الدقيقة تبعته، الذي نسميه الـSequencing تبعته
+
+93
+00:09:04,200 --> 00:09:10,100
+فهذه درجات تعقيد الموضوع، وبالتالي، بدل الواحد يكون
+
+94
+00:09:10,100 --> 00:09:19,180
+متنبه لها، نذكر مرة ثانية، أنه مقارنة بالـDNA الذي
+
+95
+00:09:19,180 --> 00:09:23,040
+هو الـDeoxyribonucleic Acid الذي فيه الـ
+
+96
+00:09:23,040 --> 00:09:30,240
+Deoxyribose كسُكر وفسفَات والأربع نيوكليوتيدات أو
+
+97
+00:09:30,240 --> 00:09:36,220
+الأربع نيتروجينيس بايزيز، التي هي الـPurines
+
+98
+00:09:36,220 --> 00:09:43,900
+والبيريميدينات، الـRNA تركيبه مختلف في ناحيتين أساسيتين
+
+99
+00:09:43,900 --> 00:09:49,520
+أول شيء، أن السكر هو الـريبوز، وليس الـ
+
+100
+00:09:49,520 --> 00:09:56,500
+دُوكسي ريبوز، والبديل للثايمين
+
+101
+00:09:56,500 --> 00:10:04,140
+في الـيوراسيل كـنيتروجينس بيس، وطبعاً يتغير
+
+102
+00:10:04,140 --> 00:10:09,280
+أنه في الجسم بشكل طبيعي، أو في غالبية الوقت، بشكل
+
+103
+00:10:09,280 --> 00:10:18,000
+طبيعي يكون على شكل Single Strand، من دراسة الأمراض
+
+104
+00:10:18,000 --> 00:10:22,140
+التي هي مثل الـAutoimmune Diseases، أمراض المناعة
+
+105
+00:10:22,140 --> 00:10:26,960
+الذاتية، التي فيه عندنا Double-Stranded RNA، ممكن
+
+106
+00:10:26,960 --> 00:10:33,960
+يتشكل بشكل مصنع، Single-Stranded DNA، يعني تجد
+
+107
+00:10:33,960 --> 00:10:39,280
+فيه أنني ممكن يكون عندي أنواع أخرى، فهل أحد لديه
+
+108
+00:10:39,280 --> 00:10:46,240
+سؤال حتى الآن؟ هذه التي هي الاختلافات بين الـRNA
+
+109
+00:10:46,240 --> 00:10:52,720
+والـDNA، الـDNA يظل داخل النواة، الـ
+
+110
+00:10:52,720 --> 00:11:00,920
+Nucleus، الـRNA يتم Transcription له، يكون هو
+
+111
+00:11:00,920 --> 00:11:07,330
+لسه داخل النواة، تتم عملية قص ولصق له، بحيث أن
+
+112
+00:11:07,330 --> 00:11:12,430
+الـFull Messenger RNA المطلوب هو الذي يتم إخراجه
+
+113
+00:11:12,430 --> 00:11:21,150
+فهنا أمثلة على أننا كثيراً في قضايا البروتينات
+
+114
+00:11:21,150 --> 00:11:27,870
+التي تكون مفيدة في الجسم وضرورية، تتم من خلال
+
+115
+00:11:27,870 --> 00:11:34,750
+استخدام قطع كثيرة من الـDNA
+
+116
+00:11:34,750 --> 00:11:42,030
+بحيث أن المنطقة التي يتم استخدامها في عمل البروتين
+
+117
+00:11:42,030 --> 00:11:47,510
+نسميها الـExon، بسبب أن مثلاً هذه القطعة بدها
+
+118
+00:11:47,510 --> 00:11:53,670
+مثلاً، أول بروتين مثلاً هذا له أربعة Exons مثلاً، أي
+
+119
+00:11:53,670 --> 00:11:59,870
+هنا فوق، والتي بينهما نسميها الـIntrons التي يتم
+
+120
+00:11:59,870 --> 00:12:08,890
+قصها، و يعني رميها، ويكون يعني لاقليات أو لهدف، يعني لا
+
+121
+00:12:08,890 --> 00:12:15,290
+أعرفه الآن، بس إحنا الـ "هي" بتكون step أو مرحلة
+
+122
+00:12:15,290 --> 00:12:19,490
+ضرورية في صناعة كثير من البروتينات، أنها تكون أكثر
+
+123
+00:12:19,490 --> 00:12:26,770
+من قطعة، وتعطي تحكماً أكبر في ناتج البروتيني من
+
+124
+00:12:26,770 --> 00:12:31,090
+هذا الجين، فالـ"هي" بشكل عام
+
+125
+00:12:33,890 --> 00:12:40,390
+حتى الاقليات، عملية الـTranscription للـDNA into
+
+126
+00:12:40,390 --> 00:12:48,150
+RNA، تبدأ، بدها تكون أول شيء تتعرف على نقطة التي هي
+
+127
+00:12:48,150 --> 00:12:53,210
+موضحة هنا بالأول، اسمها Start of Transcription
+
+128
+00:12:53,210 --> 00:13:01,390
+يعني في عادة لكل جين، في منطقة في مقدمته، يكون الـ
+
+129
+00:13:01,390 --> 00:13:07,370
+Transcription Mechanism، الميكانيكيات أو آليات
+
+130
+00:13:07,370 --> 00:13:15,470
+العمل، تفهموا أنه ابدأ من هنا، وراح يكون أن
+
+131
+00:13:15,470 --> 00:13:21,190
+الـInitiator Codon، الذي هو الكودون، الذي هو ثلاثي
+
+132
+00:13:21,190 --> 00:13:26,430
+الـNucleotides بترتيب معين، تقول ابدأ هنا، فيبدأ
+
+133
+00:13:26,430 --> 00:13:31,910
+القراءة، هذه الـDirection of Transcription، إلى أن يصل
+
+134
+00:13:31,910 --> 00:13:37,550
+في الأخير إلى الـTermination Codon الذي يقول له
+
+135
+00:13:37,550 --> 00:13:44,510
+قف هنا، وبعدين حتى يحميه، ويمشي خطوات أخرى، يكون
+
+136
+00:13:44,510 --> 00:13:50,930
+فيه Untranslated Region وPolyadenylation Signal
+
+137
+00:13:50,930 --> 00:13:56,230
+وفي أشياء إضافية، حتى تساعد في عملية التحكم في
+
+138
+00:13:56,230 --> 00:14:02,010
+الـTranscription إلى الـTranslation إلى الـProtein
+
+139
+00:14:02,010 --> 00:14:07,850
+synthesis، فمثلاً، دكتور، دكتور، نعم، ففي بس سؤال من
+
+140
+00:14:07,850 --> 00:14:12,570
+دكتورة هديل، نعم، بخصوص مستويات تركيب الـDNA، نعم
+
+141
+00:14:12,570 --> 00:14:17,510
+تقول، على أي أساس صارت الثلاثة؟ لا، إحنا لما
+
+142
+00:14:17,510 --> 00:14:24,790
+نتكلم عن الـDNA هو نفسه خط طويل، يعني يقول لك إذا
+
+143
+00:14:24,790 --> 00:14:30,110
+تلفّه، Single Nucleotides واحد وراء الثاني، يلف
+
+144
+00:14:30,110 --> 00:14:35,050
+الكرة الأرضية، ماشي؟ فأنا إذا أريد أن أتخيل كيف أريد
+
+145
+00:14:35,050 --> 00:14:38,950
+أن أتعامل معه، ممكن أنا أكون في مرحلة معينة، في لحظة
+
+146
+00:14:38,950 --> 00:14:44,230
+معينة، أتحدث عن كروموزومات، فهو أي جين موجود على
+
+147
+00:14:44,230 --> 00:14:49,880
+كروموزوم معين، في أحداث ترتبط بالـChromosomes والـ
+
+148
+00:14:49,880 --> 00:14:53,980
+Chromosomes مهمة بهذا الشكل المضغوط الذي نراه في
+
+149
+00:14:53,980 --> 00:14:58,100
+هذه اللحظة، يعني هو الـChromosome، لن يذهب، ماشي، بس
+
+150
+00:14:58,100 --> 00:15:06,500
+شكله زي يعني خيط طويل، وليس ملفوف، بل مضغوط بالـPistons
+
+151
+00:15:06,500 --> 00:15:12,200
+بشكل مضغوط كثيراً، الضغط الشديد هو الذي أحتاجه وقت
+
+152
+00:15:12,200 --> 00:15:19,360
+الـCell Division، وقتها أحتاج الكروموزوم يكون بهذا
+
+153
+00:15:19,360 --> 00:15:24,960
+الشكل الذي هو موضح أعلاه، فلما أنا أشوفه بهذا الشكل
+
+154
+00:15:24,960 --> 00:15:30,080
+هنا، بالمتوسط، كلنا، كل كروموزوم فيه حوالي ألف جين
+
+155
+00:15:30,080 --> 00:15:34,860
+فأنا لا أستطيع أن أتعامل مع الألف جين، أحياناً فيه ظواهر
+
+156
+00:15:34,860 --> 00:15:42,860
+وأمراض وحالات تكون قطعة منه فقط، سوّمرات الكروموزومات
+
+157
+00:15:42,860 --> 00:15:45,940
+كما هنا موضح، يَسمّونه الـBand، هذا الـ
+
+158
+00:15:45,940 --> 00:15:54,280
+Band، هي مرتبطة بكم عدد الجينات في هذه القطعة من
+
+159
+00:15:54,280 --> 00:16:01,320
+الـDNA أو من الكروموزوم، وبعدين بدرجة أدق، يعني الـ
+
+160
+00:16:01,320 --> 00:16:08,000
+Bands، شيء يأتي بالنص، يعني هذا الآن الذي، يعني هذا
+
+161
+00:16:08,000 --> 00:16:15,150
+الذي نريد أن نتخيله هنا، الـChromosome هذا حوالي ألف جين، الـ
+
+162
+00:16:15,150 --> 00:16:18,410
+Band الواحدة هنا التي وضعناها هي عبارة عن خمسة عشر
+
+163
+00:16:18,410 --> 00:16:23,330
+جين فقط، بس بعدين لما أدخل أنا بالتفصيل، طبعاً هنا
+
+164
+00:16:23,330 --> 00:16:29,630
+الـChromosome هذا مقسم، حوالي مثلاً نقول ثلاثون
+
+165
+00:16:29,630 --> 00:16:35,770
+Band، كل Band مثلاً فيها عشرون، ثلاثون جين، والجين
+
+166
+00:16:35,770 --> 00:16:40,890
+الواحد لسه أيضاً له تعقيد داخلي كما نراه هنا
+
+167
+00:16:40,890 --> 00:16:47,750
+فأنا أتحدث عن أن الواحد يجب أن يكون هكذا لما نقرأ
+
+168
+00:16:47,750 --> 00:16:54,710
+أي معلومة، ماشي، بده هكذا بسرعة يفهم ماذا المقصود من
+
+169
+00:16:54,710 --> 00:16:58,910
+الكلام هذا، الذي نحن نتحدث على مستوى كـ
+
+170
+00:16:58,910 --> 00:17:04,360
+Chromosome في Band معينة، نتحدث عن نفس الجين
+
+171
+00:17:04,360 --> 00:17:12,240
+الذي سنتحدث عنه مثلاً، مثلاً الـFMF، الـFamily
+
+172
+00:17:12,240 --> 0
+
+223
+00:22:07,360 --> 00:22:11,900
+Capital Letters في النهاية لما يقعدوا يشرحوا على
+
+224
+00:22:11,900 --> 00:22:16,280
+إن الشغل الإفلاني بيحط ليها كلها Capital فهو قصده
+
+225
+00:22:16,280 --> 00:22:22,000
+الـGene، ماشي؟ في سؤال ثاني، اسأله في سؤال من
+
+226
+00:22:22,000 --> 00:22:26,060
+الدكتورة أسماء بخصوص الـ«بولي أدينلةشن» بتقول
+
+227
+00:22:26,060 --> 00:22:32,180
+أنه أخذوا قبل ذلك أن يتم إضافة الـNucleotide A بعد
+
+228
+00:22:32,180 --> 00:22:36,460
+عملية إزالة الانترون، ولكن في الصورة بيتم إضافة
+
+229
+00:22:36,460 --> 00:22:44,620
+الـA قبل إزالة الانترون، والله في الصورة مبين إنه
+
+230
+00:22:44,620 --> 00:22:46,400
+في الـ«أدينلةشن» Signal
+
+231
+00:22:49,050 --> 00:22:54,190
+موجودة قبل ما يتم عملية تقطيع الـExons؟ يمكن،
+
+232
+00:22:54,190 --> 00:23:00,670
+يمكن، أنا، شوف، مئة بالمئة، بلاش ندخل التفاصيل،
+
+233
+00:23:00,670 --> 00:23:06,110
+أنا ما عندي علم أقول لك هيك بيصير أو هيك ما بيصير، بس
+
+234
+00:23:06,110 --> 00:23:13,350
+الملاحظ يعني لما تيجي الصورة هذه ماشية، اللي هي
+
+235
+00:23:13,350 --> 00:23:20,180
+بتتكلم أكثر عن الناحية هذه، إنه بطريقة ما الـ
+
+236
+00:23:20,180 --> 00:23:25,640
+«high» على مستوى الـ«DNA» بدك تفرطه وتبعده عن
+
+237
+00:23:25,640 --> 00:23:31,680
+بعض حتى تفعل الـTranscription وتمشي من الـ«5
+
+238
+00:23:31,680 --> 00:23:36,920
+End» لـ«3 End» دائماً، من «5 Prime» لـ«3 Prime»
+
+239
+00:23:36,920 --> 00:23:42,630
+ففي هنا الـ«Startup» وفي الـPromoter Region الـ
+
+240
+00:23:42,630 --> 00:23:46,930
+Promoter Region شوية منطقة أقعد شوية لقدام واللي
+
+241
+00:23:46,930 --> 00:23:51,690
+قصده فيها إنها تنبه الـTranscription Mechanism
+
+242
+00:23:51,690 --> 00:23:55,510
+هاليات الـTranscription إنه ابدأ من هون، فيه هنا
+
+243
+00:23:55,510 --> 00:24:00,190
+شيء وفي الـStartup Codon اللي هو بيقول لك ابدأ هنا
+
+244
+00:24:00,190 --> 00:24:09,700
+فبتم نسخ الـRNA كله بما فيه الـExon اللي هم هذول
+
+245
+00:24:09,700 --> 00:24:15,880
+المفيدات والـIntron اللي بدهم ينقطعوا وبتم إضافة
+
+246
+00:24:15,880 --> 00:24:24,940
+بعدين «ذيل»، ماشي أنا بفهم إن هذا يتم الاستفادة منه
+
+247
+00:24:24,940 --> 00:24:32,760
+في قضية تحريك الـMessenger RNA خارج النواة، الـ
+
+248
+00:24:32,760 --> 00:24:38,180
+Transcription بيكون خلال النواة والـAlternative
+
+249
+00:24:38,180 --> 00:24:44,480
+Splicing أو Processing of the RNA بحيث إنه هذول
+
+250
+00:24:44,480 --> 00:24:52,200
+الـIntrons بتم قصهم والـExons بتم وصلهم مع بعض،
+
+251
+00:24:52,200 --> 00:24:55,840
+بحيث يعطيني هذا اللي راح يكون مسؤول عن البروتين
+
+252
+00:24:55,840 --> 00:25:01,060
+النهائي، هذا يعني الله أعلم يمكن الـPoly-A tail
+
+253
+00:25:02,850 --> 00:25:10,910
+مطلوب عشان يتم سهولة تخريجه من النواة حتى يدخل
+
+254
+00:25:10,910 --> 00:25:14,250
+الـCytoplasm ويروح على الـRough Endoplasmic
+
+255
+00:25:14,250 --> 00:25:19,250
+Reticulum ويروح على غيره ويقدر بعدين يجي جنبه
+
+256
+00:25:19,250 --> 00:25:27,050
+الـRibosome اللي راح زي سحاب البنطلون أو سحاب
+
+257
+00:25:27,050 --> 00:25:35,020
+الجاكيت أحياناً ولا شيء بيصير، بمسك الـ الـ كل ثلاثة
+
+258
+00:25:35,020 --> 00:25:39,240
+الـnucleotides وبيقراهم وبيحط الـamino acid
+
+259
+00:25:39,240 --> 00:25:44,280
+اللازم لحيث إنه بيبني الـamino acid chain
+
+260
+00:25:44,280 --> 00:25:48,440
+المطلوبة اللي هي الـgrowing polypeptide chain
+
+261
+00:25:48,440 --> 00:25:54,540
+فالـ الـ الـterminal poly-A addition ماشي، ظاهرة
+
+262
+00:25:54,540 --> 00:26:02,660
+بتحدث، والله ما بعرف شو أهميتها 100% يعني ما بعرف إذا
+
+263
+00:26:02,660 --> 00:26:08,700
+في مثلًا ناس عندهم أمراض نتيجة إنها لا تتم أو شو
+
+264
+00:26:08,700 --> 00:26:12,240
+دورتها، بس هاي شغلة يعني الله أعلم إنها لكل
+
+265
+00:26:12,240 --> 00:26:15,760
+الجينات أو لعدد كبير من الجينات، بلاش أقول كل
+
+266
+00:26:15,760 --> 00:26:27,040
+الجينات، واضح؟ في أسئلة؟ هذه الظواهر اللي الواحد
+
+267
+00:26:27,040 --> 00:26:37,700
+بده يتذكرها، الـExpression أو المظهريًا الجين
+
+268
+00:26:37,700 --> 00:26:44,960
+مسؤول عن البروتين وبتم هذه المسؤولية وبتم هذه
+
+269
+00:26:44,960 --> 00:26:51,400
+الظاهرة من خلال الخطوات
+
+270
+00:26:51,400 --> 00:26:57,980
+هذه، Transcription وبعدين RNA Processing تقوم هنا
+
+271
+00:26:57,980 --> 00:27:01,420
+بالـTransport، لازم تكون من جوه الخلية لبره الخلية
+
+272
+00:27:01,420 --> 00:27:05,840
+بيصير عندي عملية الـTranslation من الـMessenger
+
+273
+00:27:05,840 --> 00:27:10,700
+RNA لـPolypeptide Chain وبعدين بيصير عندي الـ
+
+274
+00:27:10,700 --> 00:27:13,840
+Protein Assembly اللي هو راح يقدّم وظيفة، راح
+
+275
+00:27:13,840 --> 00:27:20,040
+يقدّم الشيء المطلوب، ماشي؟ هاي اللي يعني سموها هو
+
+276
+00:27:20,040 --> 00:27:23,620
+هنا الـFlow of Information من ديانات ورانات
+
+277
+00:27:23,620 --> 00:27:33,080
+وبروتين على شيء افتراضي، ماشي؟ الآن،
+
+278
+00:27:33,080 --> 00:27:40,940
+كيف الـDNA مسؤول عن البروتين؟
+
+279
+00:27:40,940 --> 00:27:48,360
+نتذكر إن أنا عندي أربع نيوكليك أسيد أو نيوكليوتايد
+
+280
+00:27:48,360 --> 00:27:53,710
+أو Nitrogenous bases، الأربع نيوكليوتايدات طبعًا
+
+281
+00:27:53,710 --> 00:28:00,650
+جايين بترتيب إنه كل واحد لازم يقابله شيء محدد، فإحنا
+
+282
+00:28:00,650 --> 00:28:05,130
+بنحكي عن صف واحد، من جهة واحدة لسه اللي هي من
+
+283
+00:28:05,130 --> 00:28:10,430
+الخمسة للثلاثة اللي راح يكون من خلالها عملية
+
+284
+00:28:10,430 --> 00:28:18,650
+القراءة بهذا الترتيب، نتذكر شغلة أول شيء استنتجوها
+
+285
+00:28:18,650 --> 00:28:28,170
+حسابيًا، وبعدين تبدأ بالواقع وبالمشاهدات وبالتجارب
+
+286
+00:28:28,170 --> 00:28:34,370
+وكذا، لو افترضنا طبعًا أنا بعرف إنه أنا كـProtein
+
+287
+00:28:34,370 --> 00:28:41,870
+Structure في عندي 20 Amino Acids وهي أساميهم ولهم
+
+288
+00:28:41,870 --> 00:28:47,170
+طريقة كتابتهم وراح نقرأ عنهم بعدين، في ثلاث طرق
+
+289
+00:28:47,170 --> 00:28:54,190
+ممكن، نحط ثلاث أحرف «لوسين» هذا الاسم الكامل تبعه
+
+290
+00:28:54,190 --> 00:28:59,650
+وفي أحيانًا بيرمزوا للـAmino Acid بحرف واحد اللي
+
+291
+00:28:59,650 --> 00:29:05,490
+هو الـ«L» لما نحطه، «K» اللي هو الـ«Lysine» هذا
+
+292
+00:29:05,490 --> 00:29:10,550
+اسمه، هذا كلهم Amino Acids طبعًا، الـAmino Acid
+
+293
+00:29:10,550 --> 00:29:15,920
+Structure لازم تكونوا عارفين فيه الـCarboxyl
+
+294
+00:29:15,920 --> 00:29:20,120
+Terminal وفي الـNitrogen Terminal، في الـN
+
+295
+00:29:20,120 --> 00:29:25,660
+Terminal يعني الـBackbone يعني شيء قريب من الـ من
+
+296
+00:29:25,660 --> 00:29:32,020
+الـDNA، يعني إذا تخيلنا الـDNA، الـDNA ديوكسي
+
+297
+00:29:32,020 --> 00:29:36,380
+رايبوز فوسفيت ديوكسي رايبوز فوسفيت ديوكسي رايبوز
+
+298
+00:29:36,380 --> 00:29:42,820
+فوسفيت وفي الرابطة بينهم في الـNitrogen Space، بس
+
+299
+00:29:42,820 --> 00:29:49,120
+الـ الـAmino Acids ماشي، عبارة عن فيه Carboxyl
+
+300
+00:29:49,120 --> 00:29:54,660
+Terminal اللي دائمًا بنبدأ فيه، بيبدأ بالـN Terminal
+
+301
+00:29:54,660 --> 00:29:59,720
+اللي هي البداية وبيجي بعدين الـCarboxyl Terminal
+
+302
+00:29:59,720 --> 00:30:06,440
+تبعته بالطرف، فيه Side Chain، Side Chain هي اللي هي
+
+303
+00:30:06,440 --> 00:30:12,120
+بتسوي الاختلافات بين الـAmino Acids، ففي عندنا
+
+304
+00:30:12,120 --> 00:30:18,430
+Structure متكرر اللي هو Nitrogen-based terminal
+
+305
+00:30:18,430 --> 00:30:22,270
+وCarboxyl terminal، نيتروجين تيرمينال وCarboxyl
+
+306
+00:30:22,270 --> 00:30:26,710
+terminal والـSide Chain هم اللي بيعطينا الخواص
+
+307
+00:30:26,710 --> 00:30:31,110
+الأخرى والتفاعلات الأخرى والأشياء هذه، فأنا بما أنه
+
+308
+00:30:31,110 --> 00:30:35,330
+أنا عندي، هذه مراجعة شوية للـBiochemistry، بما أنه
+
+309
+00:30:35,330 --> 00:30:42,470
+أنا عندي عشرين Amino Acid، لو كان كل Amino Acid هو
+
+310
+00:30:42,470 --> 00:30:48,560
+نتيجة قراءة نيوكليوتايد واحد أو Nitrogen Base واحدة
+
+311
+00:30:48,560 --> 00:30:53,700
+كان راح يكون إنه أنا عندي أربع Nitrogen Bases راح
+
+312
+00:30:53,700 --> 00:31:00,560
+يكونوا مسؤولين فقط عن أربع Amino Acids بالتالي،
+
+313
+00:31:00,560 --> 00:31:08,160
+ما بظبط، ما راح يكون كافي، فلو كنا اثنين، الـ2 عبارة
+
+314
+00:31:08,160 --> 00:31:12,780
+عن 4×4 صارت الاحتمالات أحسن، بل الـ16 لسة ما بيكفي
+
+315
+00:31:12,780 --> 00:31:24,500
+العشرين Amino Acids، فكانت النتيجة إنه فعليًا
+
+316
+00:31:24,500 --> 00:31:31,320
+كل 3 من الـNitrogenous Bases، كل 3 نيوكليوتايدات
+
+317
+00:31:31,320 --> 00:31:35,760
+بالترتيب اللي هم موجودين فيه بيكونوا مسؤولين عن
+
+318
+00:31:37,960 --> 00:31:44,900
+بتحديد الـAmino Acid المطلوب، إذا أخذنا أربعة
+
+319
+00:31:44,900 --> 00:31:50,240
+بأربعة بأربعة بيصير عندي أربعة وستين، شو اسمه؟
+
+320
+00:31:50,240 --> 00:31:56,280
+أربعة وستين possibility
+
+321
+00:31:56,280 --> 00:32:01,340
+والأربعة وستين، عشان  نحسب عشرين Amino
+
+322
+00:32:01,340 --> 00:32:08,630
+Acids، راح تلاحظ إنه كل أحيانًا أكثر من كودون، أكثر
+
+323
+00:32:08,630 --> 00:32:13,890
+من ثلاث من الـNucleotides ورا بعض، لما تجيب ترتيب
+
+324
+00:32:13,890 --> 00:32:20,850
+معين راح تشير لنا على نوع معين من الـAmino Acids
+
+325
+00:32:20,850 --> 00:32:27,670
+فهذا جدول اللي هم ترتيب الكودونات، ماشي؟ وكل واحد
+
+326
+00:32:27,670 --> 00:32:33,570
+شو يمثل كـAmino Acid، فمثلًا إذا جبنا إن أنا عندي
+
+327
+00:32:34,040 --> 00:32:41,240
+AAA رح هذا يعطينا الـLysine، إذا AAG كمان رح
+
+328
+00:32:41,240 --> 00:32:48,380
+يعطينا الـLysine، مثلًا هذا الـLeucine UUA بعطينا
+
+329
+00:32:48,380 --> 00:32:52,840
+الـLeucine، UUG بعطينا الـLeucine، CUU بعطينا الـ
+
+330
+00:32:52,840 --> 00:32:59,740
+Leucine، فهيك تطلعوا عليه راح تلاقوا إنه بالأخير هناك
+
+331
+00:32:59,740 --> 00:33:03,480
+العشرين amino acid فيه كل واحد منه على الأقل له
+
+332
+00:33:04,190 --> 00:33:10,010
+Codon معين، ثلاثة معينة ورا بعض تعطيك إيش هو الـ
+
+333
+00:33:10,010 --> 00:33:17,030
+Amino Acid اللازم، بالإضافة لإذا انتبهت هنا في كمان
+
+334
+00:33:17,030 --> 00:33:22,550
+واحد اسمه Stop Codon، يعني عبارة عن شيء إذا الـ
+
+335
+00:33:22,550 --> 00:33:28,030
+Mechanism تبع القراءة شافه «UAA» معناته توقف
+
+336
+00:33:28,030 --> 00:33:34,720
+«UAG» معناته توقف، «UGA» برضه توقف، وفيه مفروض واحدة
+
+337
+00:33:34,720 --> 00:33:42,020
+تكون Start، ماشي، بحاول أطلع عليها بس شكلها صعب أو
+
+338
+00:33:42,020 --> 00:33:49,960
+ما أني شايفها، ففيه الـ الـ يعني لازم يكون فيه
+
+339
+00:33:49,960 --> 00:33:53,400
+Startup
+
+340
+00:33:53,400 --> 00:34:00,320
+codon، يعني Start، وفيه شيء للـStop، حتى الـ«AUG»
+
+341
+00:34:00,320 --> 00:34:06,530
+يا دكتور، الـStart Codon عادةً بتكون، عادةً بتكون،
+
+342
+00:34:06,530 --> 00:34:12,510
+أه، مش شايفها بالجدول اللي حاطينه، ماشي، فالمهم،
+
+343
+00:34:12,510 --> 00:34:15,690
+موجود، موجود، موجود مع الـ مع وجود قبل
+
+344
+00:34:15,690 --> 00:34:23,430
+الميثيونين، أه، المهم، يعني الفكرة أنه لما
+
+345
+00:34:23,430 --> 00:34:28,860
+نيجي نقرأ، لما نعمل بنسميه الـ نقرأ الـ
+
+346
+00:34:28,860 --> 00:34:33,880
+الـNucleotides تبعات الـDNA، لقطع الـDNA في الـGene
+
+347
+00:34:33,880 --> 00:34:36,620
+أو في غيره أو Whole Genome Sequence نسميها
+
+348
+00:34:36,620 --> 00:34:42,480
+Sequencing، بدي انتبه إنه كل ثلاثة راح يعطينا
+
+349
+00:34:42,480 --> 00:34:47,520
+مقابلها Amino Acid، فهنا يعني فيه ظواهر كثيرة راح
+
+350
+00:34:47,520 --> 00:34:52,880
+نتمنى إحنا اللي اتكلمنا المرة اللي فاتت على قضية
+
+351
+00:34:52,880 --> 00:35:03,430
+إنه الـ على قضية إنه أحيانًا لو فيه ND-SNP اللي هو
+
+352
+00:35:03,430 --> 00:35:07,530
+الـSingle Nucleotide Polymorphism أحيانًا مالهاش
+
+353
+00:35:07,530 --> 00:35:13,590
+قيمة، يعني، Okay، فيه اختلاف بين ترتيب الـ
+
+354
+00:35:13,590 --> 00:35:20,010
+Nucleotides في جين معين في قراءته في حالة معينة
+
+355
+00:35:20,010 --> 00:35:25,430
+بين شخص وشخص ثاني، بس هاي بالأخير على مستوى وظيفي
+
+356
+00:35:25,430 --> 00:35:29,970
+على مستوى شكل البروتين، على شكل وظيفة البروتين
+
+357
+00:35:29,970 --> 00:35:39,030
+بعدين قد لا يكون هناك قيمة كثيرة، فإذا افترضنا هذه
+
+358
+00:35:39,030 --> 00:35:43,670
+موجودة هنا الـATG مثلًا اعتبرناها Start Codon
+
+359
+00:35:43,670 --> 00:35:50,480
+الواحد بده ينتبه، ماشي، قضية إنه بالأخير إحنا كل
+
+360
+00:35:50,480 --> 00:35:55,380
+ثلاثة نقراهم مع بعض، أكبر كارثة راح تصير في جهة
+
+361
+00:35:55,380 --> 00:36:01,140
+كلها النظام إنه لو واحد أو اثنين نيوكليوتايد يصير لهم
+
+362
+00:36:01,140 --> 00:36:06,020
+«Deletion» هذا راح يخبص الدنيا ويخربط الدنيا لأن
+
+363
+00:36:06,020 --> 00:36:11,440
+كل اللي بعده راح يصير غير مفهوم، ماشي؟ هذه ظاهرة
+
+364
+00:36:11,440 --> 00:36:15,840
+بتحدث، فإحنا هنا يعني إذا افترضنا هذا الـDNA الأول
+
+365
+00:36:16,810 --> 00:36:20,410
+راح يصير عملية الـTranscription، راح يطلع لي
+
+366
+00:36:20,410 --> 00:36:25,930
+Messenger RNA هذا بالأول قاله ابدأ هنا، الـ
+
+367
+00:36:25,930 --> 00:36:31,510
+Messenger RNA هذا الترتيب طلع مكافئ للي قبل، لما
+
+368
+00:36:31,510 --> 00:36:36,690
+نعمل عملية الـTranslation بتصير لازم تكون ثلاثيات
+
+369
+00:36:36,690 --> 00:36:43,520
+فمن أول ما بيبدأ كل ثلاثة بنصير نقرأهم، يعني هو أنا
+
+370
+00:36:43,520 --> 00:36:49,200
+أظن بالين، هستدين، لوسين، ثريونين، برولين، جليسين،
+
+371
+00:36:49,200 --> 00:36:54,060
+كذا، فبيصير الـTranscription، الـTranslation اللي
+
+372
+00:36:54,060 --> 00:36:58,420
+بعطينا البروتين اللي راح أشوفه حسب الترتيب، فاللي
+
+373
+00:36:58,420 --> 00:37:04,360
+بتحكم بترتيب شكل الـAmino Acids في البروتين هو
+
+374
+00:37:04,360 --> 00:37:10,000
+ترتيب الـNucleotides في الـDNA، كل Amino Acid هو
+
+375
+00:37:10,000 --> 00:37:18,240
+نتيجة ثلاثة ورا بعض اسمهم Codon من الـ«DNA» أو الـ
+
+376
+00:37:18,240 --> 00:37:24,800
+«RNA» المكافئ له، بنسميه Reading Frame، يعني القطع
+
+377
+00:37:24,800 --> 00:37:29,880
+اللي بنقراها هذه ضروري تكون مظبوطة تمامًا حتى
+
+378
+00:37:29,880 --> 00:37:34,140
+تطلع القراءة سليمة، غير هيك راح يطلع شيء مالوش معنى
+
+379
+00:37:34,140 --> 00:37:35,960
+يعني في أسئلة
+
+380
+00:37:41,180 --> 00:37:47,200
+الآن هذه مرة ثانية موضوع إنه أنا أحيانًا بكون في
+
+381
+00:37:47,200 --> 00:37:52,840
+عندي Exons اللي هم المنطقة اللي يتم الاستفادة منها
+
+382
+00:37:52,840 --> 00:37:56,480
+والتعامل معها وهي اللي بدنا إياها، وفي Introns
+
+383
+00:37:56,480 --> 00:38:03,680
+اللي هم ما لهم معنى، هذول يعني نظريًا يتم قصهم و
+
+384
+00:38:03,680 --> 00:38:09,820
+التخلص منهم، فإحنا نحكي بعد شوية إنه الـ«non»
+
+385
+00:38:09,820 --> 00:38:16,000
+بيسموه يعني «non-coding RNA»، ماشي، الـ«DNA» لما
+
+386
+00:38:16,000 --> 00:38:21,020
+حكينا «non-coding» كنا نقول يعني بفهمها على مستويين
+
+387
+00:38:21,020 --> 00:38:29,120
+اللي هي إنه ممكن تكون «non-coding» يعني نهائيًا لا
+
+388
+00:38:29,120 --> 00:38:37,570
+يتم نسخه، ماشي، الـIntrons بيتم نسخها بس بيتم
+
+389
+00:38:37,570 --> 00:38:42,610
+الاستغناء عنها، بس ممكن قطع من الـDNA لا يتم نسخها
+
+390
+00:38:42,610 --> 00:38:47,590
+أصلًا مش فيها بداية وإبدأ هون وPromote الـregion
+
+391
+00:38:47,590 --> 00:38:51,770
+وأشياء حتى تتحكم فيها، ففي أشياء لا يتم نسخها
+
+392
+00:38:51,770 --> 00:38:58,930
+نهائيًا، هذا بنعتبره Non-coding الـDNA
+
+445
+00:44:07,520 --> 00:44:13,000
+وهذه A2، هذه الموجودة، هذه اللي بيفيدونه الجنين
+
+446
+00:44:13,000 --> 00:44:17,880
+في بطن أمه، ما بيفيده يكون عنده من نفس هذا النوع من
+
+447
+00:44:17,880 --> 00:44:24,480
+الـ Hemoglobin، فربنا بيجعل في الجنين في مرحلة الـ
+
+448
+00:44:24,480 --> 00:44:27,820
+مرحلة الجنينية التسعة أشهر اللي هو واحد في بطن أمه
+
+449
+00:44:28,320 --> 00:44:32,100
+أنه يكون عنده شيء بيقولوله الـ S-Hemoglobin F
+
+450
+00:44:32,100 --> 00:44:36,980
+Hemoglobin، الـ S تبع الـ Sickle Cell، فالـ F
+
+451
+00:44:36,980 --> 00:44:39,560
+Hemoglobin اللي بيسموه Fetal Hemoglobin نوعية
+
+452
+00:44:39,560 --> 00:44:43,180
+مختلفة من الـ Hemoglobin، بس هو Hemoglobin، Okay
+
+453
+00:44:43,180 --> 00:44:49,500
+ميزته إن ارتباطه بالـ Oxygen أقوى، فهو بيسحب
+
+454
+00:44:49,500 --> 00:44:56,920
+الـ Oxygen من الأم، فالفكرة إنه أنا في كلنا، مش بس
+
+455
+00:44:56,920 --> 00:45:03,610
+أنا، كلنا في مرحلة الجنينية من حياتنا، بحاجة إنه
+
+456
+00:45:03,610 --> 00:45:09,470
+نكوّن Hemoglobin F وليس Hemoglobin A1 وA2 اللي
+
+457
+00:45:09,470 --> 00:45:13,490
+موجود معنا بعد الحياة، ف اللي بيصير، بس يولد
+
+458
+00:45:13,490 --> 00:45:17,690
+الإنسان، ويتغير البيئة اللي هو فيها، بيصير يبدأ يتنفس،
+
+459
+00:45:17,690 --> 00:45:24,170
+ويصير يختلف شوية شوية، الـ Hemoglobin بتتغير،
+
+460
+00:45:24,750 --> 00:45:29,310
+الجسم بيبطل يطلع الـ F-Hemoglobin، ويصير يطلع الـ
+
+461
+00:45:29,310 --> 00:45:34,830
+A1 والـ A2 Hemoglobin، فهذه ظاهرة كيف ربنا سواها
+
+462
+00:45:34,830 --> 00:45:41,230
+فينا، ليش بتحدث؟ هي طبعاً واضحة سببها إنه أنا لو
+
+463
+00:45:41,230 --> 00:45:45,970
+كان عندي نفس القوة تجذب الـ Oxygen زي الـ
+
+464
+00:45:45,970 --> 00:45:50,170
+Hemoglobin تبع الوالدين، معناته ما راح أخد Oxygen
+
+465
+00:45:50,170 --> 00:45:56,820
+منها، ما راح ينتقل الـ Oxygen، ففي لحظة معينة، الـ
+
+466
+00:45:56,820 --> 00:46:02,220
+Hemoglobin F هذا لازم هو اللي ينبني، وبعدين بس
+
+467
+00:46:02,220 --> 00:46:06,540
+نولد، هذا بيوقف، بيصير بيطلع نوع ثاني، فهذه الظواهر
+
+468
+00:46:06,540 --> 00:46:13,500
+بتحدث في جسم الإنسان كثير، وكل نوع خلايا بتلاقي فيه
+
+469
+00:46:13,500 --> 00:46:18,380
+شيء لازم يتشغل، وفيه شيء لازم يتوقف، فيه شيء بتشغل،
+
+470
+00:46:18,380 --> 00:46:21,500
+فيه شيء بتوقف، شو الآليات اللي بتتحكم في هذا الأمر؟
+
+471
+00:46:21,910 --> 00:46:25,210
+الآليات اللي بتتحكم فيه هي الـ Epigenetic
+
+472
+00:46:25,210 --> 00:46:31,330
+Mechanisms، إحنا أساساً بطلنا نتكلم شو الـ DNA نفسه
+
+473
+00:46:31,330 --> 00:46:37,350
+عنده، شو المعلومة اللي فيه، إحنا أساساً الـ يعني كل
+
+474
+00:46:37,350 --> 00:46:41,230
+خلايا الجسم راح يكون فيها الـ Hemoglobin F والـ
+
+475
+00:46:41,230 --> 00:46:48,350
+Hemoglobin S والـ A1 و A2 كجين، آه، كلها فيها الجين
+
+476
+00:46:48,350 --> 00:46:55,460
+هذا، والجينات هذه، بس في مرحلة معينة، في حياة معينة،
+
+477
+00:46:55,460 --> 00:47:01,440
+في ظرف معين بيصير فيه داعي لإيش محدد، فبيتم إنتاجه
+
+478
+00:47:01,440 --> 00:47:06,160
+أو بيتم تشغيله، أو بيتم، بيصير لما نقول عن
+
+479
+00:47:06,160 --> 00:47:09,920
+الـ DNA بيصير الـ Transcription تبعه عشان يعطينا
+
+480
+00:47:09,920 --> 00:47:15,980
+الـ Messenger RNA عشان يعطينا الـ Protein تبعه حتى
+
+481
+00:47:15,980 --> 00:47:19,740
+تقدر الوظيفة المطلوبة، فلما أنا أشوف الـ Protein طلع
+
+482
+00:47:20,300 --> 00:47:24,360
+معناته الجين تبعه اشتغل، طب ليش اشتغل؟ ليش بعدين
+
+483
+00:47:24,360 --> 00:47:29,460
+وقف؟ هذه ظواهر الـ Epigenetics، ظواهر الـ
+
+484
+00:47:29,460 --> 00:47:37,460
+Epigenetics، في جزء منها يعني راح نحكي عن فيه
+
+485
+00:47:37,460 --> 00:47:46,840
+اختلافات وتفاوت بين كمية التعديل الكيميائي على نفس
+
+486
+00:47:46,840 --> 00:47:57,570
+الـ DNA أو الـ Histones واللي هي بيعتبروها الـ
+
+487
+00:47:57,570 --> 00:48:02,610
+"هستون"، ففي عندي ظاهرة الـ "DNA methylation"، يعني
+
+488
+00:48:02,610 --> 00:48:09,870
+الـ "DNA" بعد ما كان شو اسمه؟
+
+489
+00:48:09,870 --> 00:48:16,210
+الـ "DNA" بعد ما كان بطريقته العادية مثلاً أنه في
+
+490
+00:48:16,210 --> 00:48:20,150
+مكان معين بيصير عملية "methylation" أو على الـ
+
+491
+00:48:20,150 --> 00:48:28,290
+Histone ممكن تكون فيها Variations أو Glucosylation
+
+492
+00:48:28,290 --> 00:48:33,010
+أو Methylation كمان للـ Histone أو الـ Histone-T
+
+493
+00:48:33,010 --> 00:48:38,450
+يعني الـ Histone هو القطعة
+
+494
+00:48:38,450 --> 00:48:44,590
+اللي بتلف الـ DNA عليها بشكل أكبر حتى يصغر حجمه
+
+495
+00:48:44,590 --> 00:48:51,260
+حتى نعرف ندخله كله بالكروموزوم، ماشي، إذا ما كانش فيه
+
+496
+00:48:51,260 --> 00:48:59,980
+"هستون" و "كروماتيد" أو الـ... الـ... يعني الأشياء
+
+497
+00:48:59,980 --> 00:49:04,640
+الثانية اللي هي إضافية حتى يتم عملية لف الـ DNA، ما
+
+498
+00:49:04,640 --> 00:49:09,000
+بيكون بالشكل اللي بيطلع فيه بشكل مضغوط، وبعدين يكون
+
+499
+00:49:09,000 --> 00:49:14,140
+هيك مرتب وييجي جنب بعض، وينفصلوا عن بعض، لو كان فيه
+
+500
+00:49:14,140 --> 00:49:20,060
+اختلال في اللف، مش مضغوط بشكل كبير، ممكن يخرّب
+
+501
+00:49:20,060 --> 00:49:25,360
+الدنيا، إن انفصاله ما يكون انفصال سلس وسهل متكافئ
+
+502
+00:49:25,360 --> 00:49:33,100
+مظبوط زي ما بدنا، يا واضح؟ في أسئلة؟
+
+503
+00:49:33,100 --> 00:49:38,920
+في أسئلة؟
+
+504
+00:49:38,920 --> 00:49:44,440
+ماشي، فالآن
+
+505
+00:49:45,120 --> 00:49:49,960
+الظواهر الـ Epigenetics اللي هي حكينا وتكلمنا عن
+
+506
+00:49:49,960 --> 00:49:57,060
+الـ Micro RNA أو الـ Non-coding RNA، وجوده، كيف
+
+507
+00:49:57,060 --> 00:50:05,020
+أدواره، الـ DNA methylation، الـ Histone سواء Tail
+
+508
+00:50:05,020 --> 00:50:09,720
+methylation أو Histone variation، هذه كلها ظواهر
+
+509
+00:50:09,720 --> 00:50:17,740
+موجودة، وتشترك في قضية التحكم في عملية قراءة الجينات
+
+510
+00:50:17,740 --> 00:50:22,180
+أنه الجين اللي يشتغل، وأنه الجين اللي يظل ساكن، فهذه
+
+511
+00:50:22,180 --> 00:50:27,940
+كلها ظواهر موجودة، وإن شاء الله لما ندخل بعدين في
+
+512
+00:50:27,940 --> 00:50:32,690
+بعض المحاضرات، يمكن نضرب أمثلة عليهم، بس أنا بظن إنه
+
+513
+00:50:32,690 --> 00:50:38,430
+مهم كمبدأ فكري هيك، عقلي الواحد يكون فاهمه، ويستوعب
+
+514
+00:50:38,430 --> 00:50:42,030
+لما يسمع هذه الكلمة، شو اللي موجود، وشو اللي بتكلم
+
+515
+00:50:42,030 --> 00:50:47,590
+عنه، هاي الـ Methylation فالـ Cytosine ممكن يتحول
+
+516
+00:50:47,590 --> 00:50:53,030
+لـ Methylcytosine و Five-Hydroxymethylcytosine كنوع
+
+517
+00:50:53,030 --> 01:00:03,360
+موجود، الأشياء هذه أحياناً تتدخل إنه لما يتم قراءة
+
+518
+01:00:03,360 --> 01:01:12,400
+أو تعامل الـ DNA، بتم أحياناً استخدام هذه التراكيب
+
+519
+01:01:12,400 --> 01:01:17,640
+في إنه كيف يقرأ، كيف، من وين لوين، كيف يقرأ الـ
+
+520
+01:01:17,640 --> 01:01:21,100
+Three-dimensional architecture، الـ Dynamic
+
+521
+01:01:21,100 --> 01:01:23,800
+packaging of the genome، بيوضع Increasing Level of
+
+522
+01:01:23,800 --> 01:01:28,530
+Resolution، فيه هنا الـ Individual Chromosome
+
+523
+01:01:28,530 --> 01:01:35,710
+Territories، يعني في النواة كل كروموزوم هيك لف، صارت
+
+524
+01:01:35,710 --> 01:01:40,110
+مش مضغوطة كثير زي ما بنشوفه عند الـ Karyotype في
+
+525
+01:01:40,110 --> 01:01:43,910
+الـ Cell Division، بس كل واحد إله زي ما بيقولوا هنا
+
+526
+01:01:43,910 --> 01:01:48,870
+معتبرينه إله منطقة، إله Territory، وبعدين أحياناً
+
+527
+01:01:48,870 --> 01:01:53,830
+بتفاعلوا مع بعض، بس في الأخير لما بدنا نيجي نقرأ
+
+528
+01:01:53,830 --> 01:02:00,890
+شيء بده الـ Promoter Region، تبدأ تشتغل، ويتم تحفيز
+
+529
+01:02:00,890 --> 01:02:06,010
+الآليات، نسق الـ DNA أو اللي هو الـ Transcription
+
+530
+01:02:06,010 --> 01:02:09,510
+للـ DNA، وأحياناً، يعني هون الظاهرة اللي بدي يبدأوا
+
+531
+01:02:09,510 --> 01:02:14,310
+يحكوها إنه أصل أن الـ Promoter Region إحنا بنكون
+
+532
+01:02:14,310 --> 01:02:22,110
+قبل الـ Coding Gene Segment مباشرة، بس أحياناً فيه
+
+533
+01:02:22,110 --> 01:02:27,790
+Promoter Areas أو Promoter Regions بتكون أبعد
+
+534
+01:02:27,790 --> 01:02:34,210
+بكتير، بس نتيجة الحبل الطويل ممكن يكونوا جنب بعض في
+
+535
+01:02:34,210 --> 01:02:42,210
+لحظة معينة، بحيث أن هذا يساعد على أنه آلية التحكم
+
+536
+01:02:42,210 --> 01:02:47,800
+أنه وين تبدأ في القراءة، ماشي، من وين أبدأ في الـ DNA
+
+537
+01:02:47,800 --> 01:02:55,540
+اللازم؟ فهذه قطع وظواهر بتحدث الآن
+
+538
+01:02:55,540 --> 01:03:03,200
+أنا هذا الموضوع أتوقفنا عنده المرة اللي فاتت، ويعني
+
+539
+01:03:03,200 --> 01:03:14,060
+خلّينا نفهمه من خلال أمثلة، نفترض أنا بدي أدرس الـ
+
+540
+01:03:14,060 --> 01:03:18,080
+"جين"، في أسئلة؟
+
+541
+01:03:18,080 --> 01:03:22,500
+دكتور أحمد، في إيش أسئلة؟ تقريباً لحد الآن، لأ
+
+542
+01:03:22,500 --> 01:03:29,560
+طيب، أساساً نفترض أنا بدرس الـ "ABO System Blood
+
+543
+01:03:29,560 --> 01:03:37,800
+Group"، فيه قليل، فيه مكان، وإلي أكثر من خيار،
+
+544
+01:03:37,800 --> 01:03:42,840
+ماشي؟ أنا الـ Blood Group، الـ Inheritance تبعتها
+
+545
+01:03:42,840 --> 01:03:47,440
+الـ ABO System، ومفهوم شوية، واللي ده بندخل فيها
+
+546
+01:03:47,440 --> 01:03:54,000
+تفاصيل بعدين، بيصير بس نفترض إنسان AB شو صار فيه
+
+547
+01:03:54,000 --> 01:03:59,340
+هذا الإنسان؟ لازم يكون أخذ الـ A من الأب، وأخذ الـ B
+
+548
+01:03:59,340 --> 01:04:04,840
+من الأم مثلاً، أو العكس، فالفكرة إنه في عندي Two
+
+549
+01:04:04,840 --> 01:04:09,040
+Chromosomes لهذا القليل، الآن اللي هيحكي، أنا بهمني
+
+550
+01:04:09,040 --> 01:04:16,020
+في عندي نسختين موجودة من الأب والأم، وكل واحد موجود
+
+551
+01:04:16,020 --> 01:04:22,920
+على Chromosome تبعه، وكل واحد على مستوى الجين موجود
+
+552
+01:04:22,920 --> 01:04:31,390
+أثناء حالة الـ ABO System، نفترض لحالة إنسان AB، اللي
+
+553
+01:04:31,390 --> 01:04:35,790
+راح يصير عندي بيسميه فوق Balanced Expression، شو
+
+554
+01:04:35,790 --> 01:04:41,370
+يعني؟ يعني لما أنا آجي أحفظه على مستوى البروتين
+
+555
+01:04:41,370 --> 01:04:44,890
+اللي هو الـ enzyme اللي راح يغير الـ H-antigen للـ
+
+556
+01:04:44,890 --> 01:04:49,530
+A، B-antigen، بحيث إنه أنا لما ألاقي الـ A والـ B
+
+557
+01:04:49,530 --> 01:04:54,290
+antigen، معناته الـ enzyme موجود، والـ enzyme أجى
+
+558
+01:04:54,290 --> 01:05:05,150
+من الـ RNA اللي أجى من الـ DNA، لما أنا آجي أشوف كم
+
+559
+01:05:05,150 --> 01:05:09,910
+عنده من هذا النوع ومن هذا النوع من الـ DNA ومن الـ
+
+560
+01:05:09,910 --> 01:05:19,670
+RNA، راح ألاقي إن الـ Two copies من المصدرين
+
+561
+01:05:19,670 --> 01:05:29,190
+اثنينهم شغالين، ماشي؟ المثال عندكم هنا، حطينه إنه أنا
+
+562
+01:05:29,190 --> 01:05:34,830
+بدرس الموضوع تبع إنه الـ "RNA" اللي من أبوي فيه SNP
+
+563
+01:05:34,830 --> 01:05:39,230
+إنه في هذا المكان Single Nucleotide Polymorphism
+
+564
+01:05:39,230 --> 01:05:45,350
+يعني لما قريته، كل المتشابهات متعادة، بس في مكان واحد
+
+565
+01:05:45,350 --> 01:05:53,430
+هذا طلع "G" مش الـ "A"، ماشي، فهذه بنسميها "SNP"، الـ
+
+566
+01:05:53,430 --> 01:05:58,990
+SNP هذا خلى عندي على مستوى الـ RNA أقدر أفرق بينهم
+
+567
+01:05:58,990 --> 01:06:05,810
+أما وظيفياً كشيء في الوظيفة، يمكن اثنينهم بيؤديوا
+
+568
+01:06:05,810 --> 01:06:09,490
+لنفس الـ Amino Acid، وبالتالي ما في اختلاف بالوظيفة
+
+569
+01:06:09,490 --> 01:06:14,150
+يعني هو مش إنه اختلفوا عن بعض، بس هي قراءة
+
+570
+01:06:14,150 --> 01:06:22,070
+وفهم من وين أجت هذه الـ RNA، فهنا بالمثال اللي
+
+571
+01:06:22,070 --> 01:06:26,950
+حاطينه، الـ SNP إنه على المصدر هذا اللي هو ضمن
+
+572
+01:06:26,950 --> 01:06:34,450
+الـ App بيكون إنه فيه الـ T هنا، وهنا من الـ M فيه
+
+573
+01:06:34,450 --> 01:06:41,030
+الـ C، فالـ RNA راح يكون هنا الـ G وهنا الـ A، فلما يكون
+
+574
+01:06:41,030 --> 01:06:45,550
+عندي حالة زي مثلاً واحد Blood Group تبعته AB Blood
+
+575
+01:06:45,550 --> 01:06:51,490
+Group، فيه Expression Balanced، راح يكون معروف الـ A
+
+576
+01:06:51,490 --> 01:07:00,270
+والـ B، ونفترض أنهم زي بعض، ماشي، فهي ظاهرة بتحدث أن
+
+577
+01:07:00,270 --> 01:07:07,950
+أحياناً في جينات لما نكون عندنا Two copies، اثنين هم
+
+578
+01:07:07,950 --> 01:07:13,670
+شغالين بما يرضي الله، بحيث إنه البروتين الناتج من
+
+579
+01:07:13,670 --> 01:07:20,450
+RNA لقيناه بنسبة 50% لهذا النوع، و 50% من هذا النوع،
+
+580
+01:07:20,450 --> 01:07:27,770
+ماشي؟ الآن ناخد المثال اللي تحت، وبدي أنا أركز عليه
+
+581
+01:07:27,770 --> 01:07:33,170
+من ناحية اللي أنه في المناطقة اللي هو الـ Light
+
+582
+01:07:33,170 --> 01:07:39,490
+Chain والـ Heavy Chain تبع الـ Immunoglobulin، الـ
+
+583
+01:07:39,490 --> 01:07:44,310
+Immunoglobulin، مثلاً الـ Light Chain نعرف فيه Kappa
+
+584
+01:07:44,310 --> 01:07:52,820
+و Lambda، والـ Lambda والـ Kappa، مني عندي نوعين، واحد
+
+585
+01:07:52,820 --> 01:07:57,340
+من أبوي، وواحد من أمي، والـ Lambda عندي برضه نوعين
+
+586
+01:07:57,340 --> 01:08:04,360
+واحد من أبوي، وواحد من أمي، فبالنسبة للـ Light Chain
+
+587
+01:08:04,360 --> 01:08:12,600
+Gene، في عندي أربع copies، هذول أربع copies موجودة
+
+588
+01:08:12,600 --> 01:08:18,350
+في كل خلايا الجسم، وفي الجينات، في الـ DNA، على
+
+589
+01:08:18,350 --> 01:08:24,830
+الـ Chromosome، أظن Chromosome 22، وهنا كمان موجودين،
+
+590
+01:08:24,830 --> 01:08:32,430
+ماشي، الشيء اسمه، الأربعة موجودين، Chromosomes
+
+591
+01:08:32,430 --> 01:08:39,910
+2، فعندي أربعة، نصفين، في أي خلية في الجسم، يعني
+
+592
+01:08:39,910 --> 01:08:42,770
+أنا بمسك الـ B Lymphocytes المسؤولات عن
+
+593
+01:08:42,770 --> 01:08:47,530
+الـ Immunoglobulins، وباجي بدرسهم، في اختلافات بينهم
+
+594
+01:08:47,530 --> 01:08:53,530
+إنه كل واحد منهم من الأربع نسخ من الجينات، واحدة
+
+595
+01:08:53,530 --> 01:08:58,850
+بتكون شغالة، يعني أنا باجي هنا أدرس الـ Protein
+
+596
+01:08:58,850 --> 01:09:04,050
+الناتج، واللي جاي من الـ RNA، فأنا درست الـ RNA الناتج
+
+597
+01:09:04,050 --> 01:09:10,490
+بلاقي هذا كله، آه، فاللي صار إنه في هذه الخلية
+
+598
+01:09:10,490 --> 01:09:13,310
+تحديداً
+
+599
+01:09:14,280 --> 01:09:17,840
+هذه النسخة هي اللي شغالة، وهذه النسخة تماماً مش
+
+600
+01:09:17,840 --> 01:09:25,560
+شغالة، واضح؟ فهذه أحياناً ظاهرة بتحدث بنسميها الـ
+
+601
+01:09:25,560 --> 01:09:30,240
+Monoallelic Expression أو الـ، دائماً بيقولونها
+
+602
+01:09:30,240 --> 01:09:35,220
+Allelic Exclusion، يعني إنه إذا اشتغل واحد بيمنع
+
+603
+01:09:35,220 --> 01:09:39,260
+الثاني يشتغل، فهدول
+
+604
+01:09:39,260 --> 01:09:45,400
+زي ما تقول Two Extremes، يا إما 50%، 50%،
+
+605
+01:09:45,400 --> 01:09:45,760
+50%, 50%, 50%, 50%, 50%, 50%, 50%, 50%, 50%, 50%,
+
+606
+01:09:45,760 --> 01:09:55,880
+50%, 50%, 50%, 50%, 50%, 50%, 50%, 50%, 50%, 50%,
+
+607
+01:09:55,880 --> 01:10:00,760
+50%, 50%, 50%, 50%, 50%, 50%, 50%, 50%, 50%, 50%,
+
+608
+01:10:00,760 --> 01:10:01,600
+50%, 50%, 50%, 50%, 50%, 50%, 50%, 50%, 50%, 50%,
+
+609
+01:10:01,600 --> 01:10:03,980
+50%, 50%, 50%, 50%, 50%, 50%, 50%, 50%, 50%, 50%,
+
+610
+01:10:03,980 --> 01:10:08,320
+50%, 50%, 50%, 50%, 50%, 50%, 50%, 50%, 5
+
+667
+01:05:10,940 --> 01:05:16,800
+مفكوك زيادة صحيح، ممكن تشتغل عليه وأنت لافه لف شديد،
+
+668
+01:05:16,800 --> 01:05:22,490
+ممكنش تقرأ منه إيش، لازم تفكه هيك شوية، ولما بدك
+
+669
+01:05:22,490 --> 01:05:26,690
+تصل للمنطقة اللي بدك إياها، ضروري كتير كتير لسه بدك
+
+670
+01:05:26,690 --> 01:05:34,750
+تفكها أكثر، واضح؟ إن شاء الله. الآن يعني إحنا اللي
+
+671
+01:05:34,750 --> 01:05:41,150
+بدنا نحكي إنه من الظواهر اللي كمان موجودة، إنه
+
+672
+01:05:41,150 --> 01:05:53,840
+أحيانًا الـ… الـ… الـExpression تبع الـDNA يعني
+
+673
+01:05:53,840 --> 01:05:57,460
+الـexpression للـDNA، للجين يعني، قضية شو اللي
+
+674
+01:05:57,460 --> 01:06:02,800
+يقرأ، ماشي؟ وليش أي خلية فيها الجين الفلاني
+
+675
+01:06:02,800 --> 01:06:09,260
+يقرأ، سواء نتيجة يعني من الـchromosome اللي من
+
+676
+01:06:09,260 --> 01:06:12,720
+الأب ولا من الأم، يعني هذه اللي هي الـAllelic
+
+677
+01:06:12,720 --> 01:06:17,600
+imbalance، يعني أهمية أنه أحيانًا يعني نفترض أنا
+
+678
+01:06:17,600 --> 01:06:25,340
+عندي two copies، أبوي مريض، عنده مرض معين مثلًا
+
+679
+01:06:25,340 --> 01:06:30,220
+female patient، والدها، أخذت two X-chromosomes، واحد
+
+680
+01:06:30,220 --> 01:06:34,180
+من الأم وواحد من الأب، افرض الأب عنده مرض
+
+681
+01:06:34,180 --> 01:06:41,120
+Hemophilia، هل الـHemophilia هي عندها واحد شغال من
+
+682
+01:06:41,120 --> 01:06:46,530
+الأم، صح؟ بس هل دائمًا فقط الأم اللي يشغّله ومافيش
+
+683
+01:06:46,530 --> 01:06:50,890
+إشي من الأب؟ ولا شو دخله؟ ولا كده؟ فلما يكون عندي
+
+684
+01:06:50,890 --> 01:06:56,510
+ظواهر يعني، أنا هنا بحكي اللي هي الـunbalanced
+
+685
+01:06:56,510 --> 01:07:01,790
+expression، يعني اللي هي إحنا نفترض زي الـABO
+
+686
+01:07:01,790 --> 01:07:05,010
+system، إن اثنين راح يشتغلوا، واثنين راح يجيبوا
+
+687
+01:07:05,010 --> 01:07:08,650
+خمسين بالمية من اللازم، ويعطونا الشيء الكمية اللي
+
+688
+01:07:08,650 --> 01:07:13,300
+أنا بدي إياها، زي الـABO system، فهذه اللي بيكون فيها
+
+689
+01:07:13,300 --> 01:07:18,500
+الـallelic balance، نسميه، بيكون اثنينها مشغلة، الـ
+
+690
+01:07:18,500 --> 01:07:23,700
+unbalanced expression، هو حاطين إنه حوالي من خمس
+
+691
+01:07:23,700 --> 01:07:27,080
+إلى عشرين بالمئة من الـautosomal genes، يعني هي
+
+692
+01:07:27,080 --> 01:07:33,540
+ظاهرة بتحدث في نسبة قليلة من الـautosomal genes،
+
+693
+01:07:33,540 --> 01:07:38,680
+ناشي؟ فالـ ليش؟
+
+694
+01:07:40,360 --> 01:07:47,580
+هنا يعني بالأخير epigenetic changes، يعني ظواهر
+
+695
+01:07:47,580 --> 01:07:51,580
+معينة، يمكن درجة الـmethylation لهذه الأشياء غير
+
+696
+01:07:51,580 --> 01:07:54,740
+درجة الـmethylation لهذا الـ يعني الـcopy من
+
+697
+01:07:54,740 --> 01:07:58,580
+الأب غير الـcopy من الأم في درجة الـmethylation
+
+698
+01:07:58,580 --> 01:08:05,160
+مثلًا، فخلت واحدة تقدر تكون أنجح مثلًا، وهذه يعني
+
+699
+01:08:05,160 --> 01:08:11,470
+نسبة قليلة من الجينات بتتأثر بهذه الظاهرة، والـ يعني
+
+700
+01:08:11,470 --> 01:08:21,650
+في الغالب هذه في المرحلة الأولى من الحياة، النواحي
+
+701
+01:08:21,650 --> 01:08:27,850
+الثانية، الأمثل الثانية، حاطينا أربعة أنه أربعة
+
+702
+01:08:27,850 --> 01:08:32,250
+بيكونوا واحدة من الـtwo copies هي الشغالة
+
+703
+01:08:32,250 --> 01:08:38,530
+والثانية نهائيًا مش شغالة، ماشي؟ فهي اللي بيسموها
+
+704
+01:08:38,530 --> 01:08:42,210
+"monoallelic expression"، حكينا قبل شوية على
+
+705
+01:08:42,210 --> 01:08:45,550
+الخلايا اللمفاوية T والـB lymphocytes
+
+706
+01:08:45,550 --> 01:08:48,590
+للـimmunoglobulin، الـheavy and light chains
+
+707
+01:08:48,590 --> 01:08:51,410
+وللـalpha وbeta chains تبعات الـT
+
+708
+01:08:51,410 --> 01:08:57,350
+cell، فهدول في somatic rearrangement، يعني
+
+709
+01:08:57,350 --> 01:09:06,220
+بطريقة ما حتى تصير مكوّنة، إمكانية إنه يكون عندنا
+
+710
+01:09:06,220 --> 01:09:11,380
+antibodies، ومناعة تهاجم أي شيء في الحياة، أي شيء
+
+711
+01:09:11,380 --> 01:09:17,100
+في الكون، أي شيء ممكن نتعرض إليه، يعني الـTCR
+
+712
+01:09:17,100 --> 01:09:20,340
+والـimmunoglobulin، نتكلم عن عشرة أو أس أحد عشر لعشرة
+
+713
+01:09:20,340 --> 01:09:25,260
+أو أس ثمانية عشر antibodies، variable region، فلما
+
+714
+01:09:25,260 --> 01:09:31,360
+تكون هذه الشغلة تمت، بصير قص ولسق في الـDNA اللي
+
+715
+01:09:31,360 --> 01:09:37,390
+يسمونه somatic rearrangement، فهذه الظاهرة يعني
+
+716
+01:09:37,390 --> 01:09:43,450
+مكلفة جدًا، وأنا مثلًا للـB-lymphocytes للـ
+
+717
+01:09:43,450 --> 01:09:46,790
+immunoglobulins، بكون عندي two copies، واحد على
+
+718
+01:09:46,790 --> 01:09:51,930
+كروموزوم 14 من أبوي، واحد على كروموزوم تبع أمي،
+
+719
+01:09:51,930 --> 01:09:56,930
+بيكون في أي خلية B-lymphocyte، واحد شغال، مايكونوش
+
+720
+01:09:56,930 --> 01:10:01,170
+اثنين شغالين في نفس الخلية، في خلية بتشغل هذا الـ
+
+721
+01:10:01,170 --> 01:10:05,700
+copy، في خلية مشغلة الـcopy الثانية، بالنسبة للـ
+
+722
+01:10:05,700 --> 01:10:10,520
+light chain، في عندي أربع نسخ برضه، واحد من الأربع
+
+723
+01:10:10,520 --> 01:10:15,000
+هي اللي شغّالة، والثلاث الثانيات، يا إما مجرّبات، يا
+
+724
+01:10:15,000 --> 01:10:20,260
+إما مش مجرّبات، بس بالأخير أي B-lymphocyte ناجحة
+
+725
+01:10:20,260 --> 01:10:25,880
+يكون فيها one copy، لـone قليل هو اللي بس شغال،
+
+726
+01:10:25,880 --> 01:10:31,820
+الثاني ساكن، مافيش إله expression، فهي ظاهرة موجودة،
+
+727
+01:10:31,820 --> 01:10:36,610
+وظاهرة مهمة، وبيسموها من خلال الـsomatic
+
+728
+01:10:36,610 --> 01:10:40,830
+rearrangement، وهي ظاهرة يعني متأكدة منها وسهلة
+
+729
+01:10:40,830 --> 01:10:47,410
+ومفهومة، يعني فيه كانوا يقولوا لنا وإحنا طلاب من
+
+730
+01:10:47,410 --> 01:10:52,530
+زمان، على X-chromosome inactivation، يعني بالنسبة
+
+731
+01:10:52,530 --> 01:11:00,330
+بالذات للـfemales، لما أنا آجي أدرس الـ… لما أنا
+
+732
+01:11:00,330 --> 01:11:07,400
+آجي أدرس كيف أنه الـX-chromosome اللي بيشتغل راح
+
+733
+01:11:07,400 --> 01:11:12,420
+نلاقي إنه كل خلاياها راح تنقسم يا إما خلية
+
+734
+01:11:12,420 --> 01:11:17,220
+بتشتغل على الـchromosome مثلًا X تبع الأب، أو الـ
+
+735
+01:11:17,220 --> 01:11:22,980
+chromosome تبع الأم، وهذه بالـearly embryogenesis،
+
+736
+01:11:22,980 --> 01:11:27,600
+ماشي، ظاهرة بتحدث، بالتالي إذا مثلًا في copy فيها
+
+737
+01:11:27,600 --> 01:11:32,590
+مرض وفي copy مافيش فيها مرض، ماشي؟ على مستوى
+
+738
+01:11:32,590 --> 01:11:38,250
+الجزيئي، على مستوى الـbiochemical، على مستوى أدرس
+
+739
+01:11:38,250 --> 01:11:43,830
+الـRNA والبروتين الموجود في الخلية هذه، بيلاقيه
+
+740
+01:11:43,830 --> 01:11:49,530
+كله من مصدر واحد، مش من المصدرين في نفس الخلية، فهذه
+
+741
+01:11:49,530 --> 01:11:53,950
+بدنا نسميها "mono-allelic expression"، فهي ظاهرة
+
+742
+01:11:53,950 --> 01:12:00,990
+بتحدث، اللي حاطينا هنا أنتَ هذه الأصل أنتَ هيك موجود،
+
+743
+01:12:02,360 --> 01:12:07,820
+وشكلها ظاهرة بتحدث لـ… يعني فيه لها X-
+
+744
+01:12:07,820 --> 01:12:16,240
+inactivation center، حاطينه هنا فالخلية
+
+745
+01:12:16,240 --> 01:12:24,380
+في الـearly embryogenesis، في بداية تخلّق الخلايا
+
+746
+01:12:24,380 --> 01:12:28,660
+في جسم الإنسان، في المرحلة الأولى لما عدد الخلايا
+
+747
+01:12:29,240 --> 01:12:39,040
+120، 40، كذا، بتتم انقسامها، أو بتتم ملاحظة إنه بس
+
+748
+01:12:39,040 --> 01:12:42,200
+نصها واحدة من الـX-chromosome شغّالة والثاني
+
+749
+01:12:42,200 --> 01:12:46,960
+بيعطينا اسمه bar body، بكون هكذا، condensed
+
+750
+01:12:46,960 --> 01:12:55,960
+وunactivated، فالـ… هنا مثلًا، هذا تبع الأب الشغال
+
+751
+01:12:55,960 --> 01:13:00,350
+وهذا تبع الأم اللي كان نايم، الخلية الثانية جنبها،
+
+752
+01:13:00,350 --> 01:13:06,190
+لأ، تبع الأم هو اللي شغال وتبع الأب، أو بالعكس اللي
+
+753
+01:13:06,190 --> 01:13:12,010
+نايم، فـserial and clonal maintenance of that gene
+
+754
+01:13:12,010 --> 01:13:24,250
+هذا يعني بيعطينا تفسير، تخيّل أنه أنا بفترض لو إنسان
+
+755
+01:13:24,250 --> 01:13:31,060
+عنده two copies للـX-chromosome عليهم مرض معين،
+
+756
+01:13:31,060 --> 01:13:37,300
+الأصل إذا كان الـchromosome الواحد شغال، شغال كويس
+
+757
+01:13:37,300 --> 01:13:42,680
+وبيعطينا الشيء المطلوب، أن هذه المرأة مش بس إنها
+
+758
+01:13:42,680 --> 01:13:46,940
+حاملة، حاملة، ممكن تنقل لأطفالها، بس الأصل ما يكون
+
+759
+01:13:46,940 --> 01:13:50,800
+عندها مرض، بس لو لقينا درجة بسيطة من المرض، شو
+
+760
+01:13:50,800 --> 01:13:56,200
+معناته؟ معناته إنه صار في جزء من الخلايا في جسمها
+
+761
+01:13:56,200 --> 01:14:01,560
+فعلاً حاملة، لو بتعرض الجين أو بتعرض البروتين أو
+
+762
+01:14:01,560 --> 01:14:07,400
+بتعرض الشيء اللي عامل المشكلة، وبالتالي فبتكون
+
+763
+01:14:07,400 --> 01:14:12,320
+عندها نسبة من المرض أخف، مش مقارنة زي الذكر اللي
+
+764
+01:14:12,320 --> 01:14:16,020
+بيكون بس 1X وده disease بيكون catastrophic، يعني
+
+765
+01:14:16,020 --> 01:14:20,500
+شيء قوي كثير، بس ما بتكونش normal زي الإنسان العادي،
+
+766
+01:14:22,650 --> 01:14:28,970
+فهدول ظاهرتين سهلتين، random allelic silencing أو
+
+767
+01:14:28,970 --> 01:14:33,610
+activation، أو genomic imprinting بالأخير، هدول
+
+768
+01:14:33,610 --> 01:14:37,570
+epigenetic details،
+
+769
+01:14:37,570 --> 01:14:43,290
+أنا والله يعني، بالذات على هدول الظواهر يعني مش
+
+770
+01:14:45,390 --> 01:14:50,470
+يعني مش aware الآن على شو الحالة، شو المرض، شو
+
+771
+01:14:50,470 --> 01:14:56,830
+الشيء اللي بحكوا عنه، بس يعني بالأخير يعني الرسالة
+
+772
+01:14:56,830 --> 01:15:05,070
+اللي بدنا إياها، أنه أنا عندي أكثر أحيانًا one pair،
+
+773
+01:15:05,070 --> 01:15:11,190
+أحيانًا أكثر من نفس الـgene، وحتى لو عندي أكثر من
+
+774
+01:15:11,190 --> 01:15:19,810
+pair، هناك لسه كمان درجة من التعقيد في إنه كمية الـ
+
+775
+01:15:19,810 --> 01:15:26,850
+transcription، إنه شو درجة الشغل، لو كان، يعني هسه
+
+776
+01:15:26,850 --> 01:15:30,830
+صحيح فيه جينات معينة في خلايا معينة، بدك إيه؟ red
+
+777
+01:15:30,830 --> 01:15:34,370
+blood cell، بدها الـhemoglobin مثلًا، الـ
+
+778
+01:15:34,370 --> 01:15:36,530
+immunoglobulin، أو الـB-lymphocyte بدها الـ
+
+779
+01:15:36,530 --> 01:15:40,230
+immunoglobulin، جين يشتغل بس، طب أنا عندي أكثر من
+
+780
+01:15:40,230 --> 01:15:45,600
+خيار، شو بيشتغل؟ عندي two copies بيشتغلوا تمامًا زي
+
+781
+01:15:45,600 --> 01:15:52,080
+بعض، أحيانًا نعم، بس في خمس لعشرين بالمئة من الـ
+
+782
+01:15:52,080 --> 01:15:58,080
+autosomal genes بيصير unbalanced، ممكن توصل إنه
+
+783
+01:15:58,080 --> 01:16:02,480
+monoallelic expression، إنه 100% من مصدر، المصدر
+
+784
+01:16:02,480 --> 01:16:09,910
+الثاني، والميل ودخل، وممكن يكون نسب أقل متفاوتة ما
+
+785
+01:16:09,910 --> 01:16:13,950
+بين خمسين بالمئة وخمسين بالمئة، ومئة بالمئة وصفر،
+
+786
+01:16:13,950 --> 01:16:19,750
+فكل الظواهر اللي بتتكلم عنها هي بنسميها epigenetic
+
+787
+01:16:19,750 --> 01:16:27,050
+influences، epigenetic control، ماشي، والسبب من ليش
+
+788
+01:16:27,050 --> 01:16:31,030
+بنسميه epigenetic مش genetic، لأنه الـgene نفسه
+
+789
+01:16:31,030 --> 01:16:34,290
+الـgene ما تغيّر، الـgene هو اللي بدي يعطينا
+
+790
+01:16:34,290 --> 01:16:39,950
+البروتين هذا، لسه بينهم ما فيش هالفرق، يعني ما كانش
+
+791
+01:16:39,950 --> 01:16:45,790
+فيه فرق ناتج عن الجين نفسه، في أسئلة؟ دكتور، في
+
+792
+01:16:45,790 --> 01:16:52,050
+سؤال، بس أخير من الدكتورة، أعتقد، بخصوص الـclonal
+
+793
+01:16:52,050 --> 01:16:56,270
+maintenance، بعد ما تصير عملية الـclonal
+
+794
+01:16:56,270 --> 01:17:02,010
+maintenance، معناته أنه إذا بدأت بشكل معين، بتكمل
+
+795
+01:17:02,010 --> 01:17:07,750
+بهذا الشكل، ماشي؟ يعني بيصير جوا جسم الإنسان
+
+796
+01:17:07,750 --> 01:17:14,190
+مجموعتين من الخلايا بالنسبة لهذا الـgene، ماشي؟
+
+797
+01:17:14,190 --> 01:17:20,750
+يعني نفترض chromosome معين، أو الـX-chromosome
+
+798
+01:17:20,750 --> 01:17:27,070
+مثلًا، اللي حطينا عليه قبل شوية الآن،
+
+799
+01:17:27,070 --> 01:17:32,590
+إما هعمل، مثلًا نقول بالـG6PD deficiency، ماشي، فيه
+
+800
+01:17:32,590 --> 01:17:38,530
+الـG6PD، الـ… الـenzyme هذا، فيه على الـX-chromosome،
+
+801
+01:17:38,530 --> 01:17:49,310
+وفيه مرض، فس… الـ… الـ… الـ… الـ… لما نتكلم عن شو
+
+802
+01:17:49,310 --> 01:17:57,530
+اسمه؟ الـ… الـ… الخلايا تبعت الـ… الـ… اللي بظن
+
+803
+01:17:57,530 --> 01:18:05,840
+الواحد إذا كان، بديت إنسان ذكر وقعدت أفحص في الـ
+
+804
+01:18:05,840 --> 01:18:12,380
+expression تبع هذا الـجين، ماشي؟ بلاقي إن كل
+
+805
+01:18:12,380 --> 01:18:17,940
+خلايا مش قادرة تعمل البروتين اللي أنا بدي إياه،
+
+806
+01:18:17,940 --> 01:18:23,700
+بس في مرحلة مبكرة في حياة الأنثى، بكون أنا عندي
+
+807
+01:18:23,700 --> 01:18:28,540
+two copies، بس ما يصير اثنينهم يشتغلوا، أحيانًا بتكون
+
+808
+01:18:28,540 --> 01:18:33,500
+إنه لهذا لغرض الجين معين، لسبب معين، لشغل معينة
+
+809
+01:18:33,500 --> 01:18:39,380
+بتلاقي بس نسخة واحدة اشتغلت، ففي مرحلة معينة يمكن
+
+810
+01:18:39,380 --> 01:18:45,340
+يكون مش 100%، 50%، 50%، خلايا شغّلت هذا الجين وخلايا
+
+811
+01:18:45,340 --> 01:18:50,540
+شغّلت هذا الجين، يمكن مثلًا 20%، 80%، شيء شغّل هذا
+
+812
+01:18:50,540 --> 01:18:57,760
+الجين، و80% شغّل الجين الثاني، الـ20% بيظلوا 20%، كل ما
+
+813
+01:18:57,760 --> 01:19:04,640
+بنقسمه بيظلوا نفسهم من ناحية تشغيلهم لأي نسخة من
+
+814
+01:19:04,640 --> 01:19:10,420
+الـX-chromosome، والمجموعة الثانية بتظل تشغل نفس
+
+815
+01:19:10,420 --> 01:19:18,000
+الـجين، يعني هذه خاصية بتظل تورّث في الخلايا الناتجة عن
+
+816
+01:19:18,000 --> 01:19:22,960
+انقسام الخلية اللي ظهرت فيها هذه الخاصية، واضح؟
+
+817
+01:19:25,080 --> 01:19:29,560
+طبعًا، دكتور، بس ثاني من الـ أو النقطة يعني الحابب
+
+818
+01:19:29,560 --> 01:19:32,900
+الكريم، أنه اتّضح أنه عمره يأخذ الـchromosomal
+
+819
+01:19:32,900 --> 01:19:36,980
+domain اللي حكينا عنه قبل شوية، فيه مكان للنقطة دي،
+
+820
+01:19:36,980 --> 01:19:42,880
+يعني ما لها الـchromosomal domain؟ بدّه تعيد بس
+
+821
+01:19:42,880 --> 01:19:47,340
+النقطة يعني أو الشرح إلها، يعني إيش هي أو تطلع يعني
+
+822
+01:19:47,340 --> 01:19:52,040
+يعني، يعني ما تأخذوش المواضيع كثيرة، ماشي، احنا
+
+823
+01:19:52,040 --> 01:19:57,490
+بهمنا الشيء بالذات إذا إله تطبيق سريري، إذا إله
+
+824
+01:19:57,490 --> 01:20:09,290
+أهمية، حتى أقدر أنسخ وأعمل transcription للـDNA، بدي
+
+825
+01:20:09,290 --> 01:20:16,410
+حبل الغسيل، حبل سلك الغسيل يكون المفروض إذا ملفوف
+
+826
+01:20:16,410 --> 01:20:21,860
+كثير كثير كثير، ما أعرفش أستخدمه، واضح؟ ف… صحيح، وأنا
+
+827
+01:20:21,860 --> 01:20:24,700
+دكتور برضه يعني بركّز على هذه النقطة، يعني قضية إنه
+
+828
+01:20:24,700 --> 01:20:30,040
+يعني ما تسألوش عن أشياء يعني عشان ما تصير مطلوب
+
+829
+01:20:30,040 --> 01:20:33,440
+منكم، يعني قضية الدكتور معتز برضه بيسأل عن الـ
+
+830
+01:20:33,440 --> 01:20:38,000
+"خدها ببساطة"، "خدها ببساطة"، يعني الدكتور معتز برضه
+
+831
+01:20:38,000 --> 01:20:41,360
+بيسأل عن "genomic imprinting"، الدكتور، طب يعني ما
+
+832
+01:20:41,360 --> 01:20:45,280
+أعرفش حاجاته، لو فرقته، أنا بقول لك هي نوع من الـ يعني
+
+833
+01:20:45,280 --> 01:20:49,380
+نوع من الـepigenetic mechanisms، بس في ملاحظة يعني
+
+834
+01:20:49,380 --> 01:20:55,440
+بدكم تفهموها، شغلة، الكتاب هذا مع أنه ممتاز وup to
+
+835
+01:20:55,44
+
+889
+01:25:59,890 --> 01:26:03,410
+تسددوش على حالك و ترجعوا تسألوا عنها وخلاص يعني
+
+890
+01:26:03,410 --> 01:26:06,850
+طالما الدكتور ما ركز عليها فالتركيز عليها مش هيكون
+
+891
+01:26:06,850 --> 01:26:11,910
+بالقدر اللي الدكتور شاهو يعني صحيح.. صحيح المراجع
+
+892
+01:26:11,910 --> 01:26:18,310
+اللي زي هيك أنا بقول يعني، يعني إذا الواحد عنده
+
+893
+01:26:18,310 --> 01:26:22,830
+اهتمام بمرض معين، بحالة معينة، بده يفهم جانب معين،
+
+894
+01:26:22,830 --> 01:26:28,550
+مش غلط، يكون طبعاً يعني في عصر الـNet والإنترنت
+
+895
+01:26:28,550 --> 01:26:34,330
+و Google وكذا، ممكن الأمور اختلفت، بس عيب
+
+896
+01:26:34,330 --> 01:26:39,040
+المصادر الثانية في المعلومات اللي هي قضية إن
+
+897
+01:26:39,040 --> 01:26:44,660
+أحيانًا مش موثقة، الـNet يمكن تقع في مصدر يعتبر
+
+898
+01:26:44,660 --> 01:26:51,640
+ضعيف، يعتبر بالأخير أي معلومة ممكن تكون عبارة عن
+
+899
+01:26:51,640 --> 01:26:59,740
+نسميها رأي شخص معين يعني، مش عارف عليا؟ مش قصدي
+
+900
+01:26:59,740 --> 01:27:08,860
+حقيقة، فالآن لما نقرأ هذا الكتاب ماشي، أنا بأعتبر إذا
+
+901
+01:27:08,860 --> 01:27:13,400
+الواحد بده يدرس طب ويكون عنده خصوصا يعني أنا مقدر
+
+902
+01:27:13,400 --> 01:27:17,660
+أنه عندكم امتحانات ثانية ومواد ثانية ومواضيع ثانية
+
+903
+01:27:17,660 --> 01:27:25,610
+مطلوبة منكم، أنه الواحد بده ياخد زي ما تقول يركز في
+
+904
+01:27:25,610 --> 01:27:31,690
+ذهنه على إنه يستوعب المفاهيم ويستوعب المفاهيم بقدر
+
+905
+01:27:31,690 --> 01:27:38,430
+المستطاع من خلال أمثلة تقرب له الفهم وتكون يعني
+
+906
+01:27:38,430 --> 01:27:44,450
+فيه الها يعني شيء هو شافه يعني أنا والله، آه والله
+
+907
+01:27:44,450 --> 01:27:47,960
+شوفت ثلاسيميا أو شوفت Skills of Anemia شايف Down
+
+908
+01:27:47,960 --> 01:27:51,760
+Syndrome، شايف ناس عندهم Cancer، الأشياء اللي أنت
+
+909
+01:27:51,760 --> 01:27:56,980
+بتشوفها لما تكون إشي بتكون بتشوفه إنك تفهم بدقة
+
+910
+01:27:56,980 --> 01:28:01,500
+ليش هذا الأمر حدث، هذا ضروري جداً، فلما يكون حد
+
+911
+01:28:01,500 --> 01:28:06,120
+بيشرح لك التفصيل زيادة، يا ريت يكون عندي مرجع أقدر
+
+912
+01:28:06,120 --> 01:28:12,460
+أرجع له عشان أقرأ عن هذه الحالة، أما ك الآن مفاهيم
+
+913
+01:28:12,980 --> 01:28:19,740
+بالذات إن نتكلم عن المناعة، عن الوراثة، المفاهيم
+
+914
+01:28:19,740 --> 01:28:26,460
+يعني، بدل واحد لما نتكلم على شو يعني الـStructure
+
+915
+01:28:26,460 --> 01:28:30,980
+of the DNA، فيه كروموزوم، المقصود كروموزوم موجود،
+
+916
+01:28:30,980 --> 01:28:35,820
+سواء يعني الحبل هذا لفته ولا فرته، ما هو حبل،
+
+917
+01:28:35,820 --> 01:28:40,740
+بالأخير حبل، ماشي؟ في حالة الـCell Division، بديها
+
+918
+01:28:40,740 --> 01:28:45,130
+مضغوط كتير، في حالة اللي لما بدي أشتغل عليها، بدي
+
+919
+01:28:45,130 --> 01:28:51,730
+أفكه، لما أنا أفكه، مرات بفكه نصف فكة عشان يعني
+
+920
+01:28:51,730 --> 01:28:56,890
+بكون فيها مجال وقتها إنه فيه promoter regions في
+
+921
+01:28:56,890 --> 01:29:00,870
+بعض الـpromoter regions قبل الجين تماماً وفيه
+
+922
+01:29:00,870 --> 01:29:05,290
+promoter regions ممكن تكون بعيد عنه، بما فيها بعيد
+
+923
+01:29:05,290 --> 01:29:09,870
+عنه حتى لو على كروموزوم ثاني، بس لأنه كل واحد إله
+
+924
+01:29:09,870 --> 01:29:15,930
+مكانه، ماشي، هيك باحتفظ فيه، الأمور بالنسبة للاسلاك
+
+925
+01:29:15,930 --> 01:29:19,850
+هذه والاحبال هذه، ماشي، حاجة بتقدر الوظيفة المطلوبة
+
+926
+01:29:19,850 --> 01:29:25,030
+يعني خليها بشكل مبسط، ولما أنتم تقرأوا من الكتاب
+
+927
+01:29:25,030 --> 01:29:32,570
+تطلعوا الصور، اقرأوا الجداول، اقرأوا المربعات
+
+928
+01:29:32,570 --> 01:29:36,550
+هيك اللي حاطط فيها شيء، اقرأوا المقدمة واقرأوا
+
+929
+01:29:36,550 --> 01:29:44,010
+الختام، يعني دائماً إذا بيحط لك شيء هو بيكون بديك
+
+930
+01:29:44,010 --> 01:29:48,230
+تفهم مفهوم معين، هذا اللي بيهمنا، ماشي؟ الـToo
+
+931
+01:29:48,230 --> 01:29:54,150
+much details مش مطلوبة، ماشي؟ ومش شطارة يعني، ومش
+
+932
+01:29:54,150 --> 01:30:02,350
+بالذات إذا شغل يعني يمكن مش متفق عليها، ماشي؟ طبعاً
+
+933
+01:30:02,350 --> 01:30:05,170
+نستغل وجودك يا دكتور برضه في نقطة ثانية يعني أنه
+
+934
+01:30:05,170 --> 01:30:09,790
+الجدول اللي بعثناه للطلاب، صحيح إنه فيه يعني
+
+935
+01:30:09,790 --> 01:30:12,670
+هذا الكلام بوجهه للطلاب يعني، صحيح إنه فيه 18
+
+936
+01:30:12,670 --> 01:30:16,490
+chapter موجودين، لكن طبيعي مش هيغطي شرح الـ18
+
+937
+01:30:16,490 --> 01:30:19,810
+chapter بالتفصيل، يعني الدكتور وصلني صورة ويعني
+
+938
+01:30:19,810 --> 01:30:24,650
+أتمنى أن أؤكدها كمان، أجابت إن الشابتر الأخيرة لن
+
+939
+01:30:24,650 --> 01:30:27,770
+تتم،  تؤخذ الأمراض فيها بالتفاصيل، لأن هذه كلها
+
+940
+01:30:27,770 --> 01:30:31,530
+أمراض سريرية، التفاصيل
+
+941
+01:30:31,530 --> 01:30:36,970
+السريرية طبعاً، ما هذه كل حياتك بدك تتعلم عليها، وهي
+
+942
+01:30:36,970 --> 01:30:41,750
+لمرحلة لاحقة بالظبط، الأمراض السريرية ما بدنا ندخل
+
+943
+01:30:41,750 --> 01:30:45,880
+تفاصيلها، يعني ثمانية عشر شابتر صحيح عدد لكن في
+
+944
+01:30:45,880 --> 01:30:48,820
+المضمون هيكون على عدد الأسابيع اللي موجودة اللي هي
+
+945
+01:30:48,820 --> 01:30:53,140
+14 أو 13 أسبوع بالظبط، يعني مش هنأخذ ثمانية عشر شابتر
+
+946
+01:30:53,140 --> 01:30:59,240
+بالتفصيل، يعني المفهوم بترسخ من خلال المثال، صحيح
+
+947
+01:30:59,240 --> 01:31:04,820
+مثال، إذا أنت فاهم كمريض إنه في حالة اسمها كذا، بيجي
+
+948
+01:31:04,820 --> 01:31:08,460
+المريض عنده هيك، لاحظنا عليه هيك، ليش بيكون هيك
+
+949
+01:31:08,460 --> 01:31:13,520
+فأنت هنا بتسيب، يعني ممكن حتى طبعاً يمكن الآن على
+
+950
+01:31:13,520 --> 01:31:19,660
+مستوى طالب طب ثاني ثالث، بدايته يمكن يعني
+
+951
+01:31:19,660 --> 01:31:24,360
+معلومات كثيرة وتفاصيل كثيرة، بس إحنا بناخدها، أنا
+
+952
+01:31:24,360 --> 01:31:30,430
+بيهمّني الأمثلة اللي بتوضح المفهوم، فاهم عليّ كيف؟
+
+953
+01:31:30,430 --> 01:31:34,230
+يعني لما تقول لي A.B.O System كلكم بتعرفوا كيف
+
+954
+01:31:34,230 --> 01:31:37,330
+الـGenetics تبعته، ومين الـDominant ومين
+
+955
+01:31:37,330 --> 01:31:40,670
+الـRecessive
+
+956
+01:31:40,670 --> 01:31:45,050
+وكيف بيكون وكيف كذا وكيف كذا، فيعني هذه الأشياء أنا
+
+957
+01:31:45,050 --> 01:31:50,190
+بيهمني المفاهيم، والمفاهيم يتم شرحها في شكل مبسط من
+
+958
+01:31:50,190 --> 01:31:55,450
+خلال أمثلة، فإذا في مثال يعني بالذات بيبين مفهوم
+
+959
+01:31:55,450 --> 01:32:01,560
+معين، كويس، والواحد هيك ياخده بشكل مبسط، عشان نأخذ
+
+960
+01:32:01,560 --> 01:32:06,840
+بالتفاصيل الدقيقة، وإن كان يعني إذا الواحد يعني هسا
+
+961
+01:32:06,840 --> 01:32:11,480
+سمع الـ يعني هسا الـband اللي فلان في الـ
+
+962
+01:32:11,480 --> 01:32:14,700
+chromosome اللي فلان، أنت بتتخيل وين هي، شو هي،
+
+963
+01:32:14,700 --> 01:32:19,820
+ماشي، ولما نتلاقى الـsegment فيها كده من gene كيف
+
+964
+01:32:19,820 --> 01:32:24,460
+ترتيبها وكم intron وكم exon وكده، يعني لما أنا أقول
+
+965
+01:32:24,460 --> 01:32:28,670
+والله الـFMF، الجين اللي هو الـPyrene الـ
+
+966
+01:32:28,670 --> 01:32:34,250
+exon رقم 2 ورقم 10 هم اللي فيهم polymorphism اللي
+
+967
+01:32:34,250 --> 01:32:38,690
+هي حوالي 200 نوع polymorphism وإذا كان double يعني
+
+968
+01:32:38,690 --> 01:32:42,950
+double heterozygous أو homozygous هي اللي بتكون
+
+969
+01:32:42,950 --> 01:32:48,930
+شديدة وكذا وكذا، يعني بتعطيك تصور بساعدك في فهم
+
+970
+01:32:48,930 --> 01:32:53,230
+المرض، بساعدك في قراءة المعلومات إذا قريتها من مجلة
+
+971
+01:32:53,230 --> 01:33:01,560
+أو من مرجع، طبعاً إن شاء الله، إن شاء الله خير، أنا إن
+
+972
+01:33:01,560 --> 01:33:07,000
+شاء الله يعني اليوم الـchapter الثالث جاي مش طويل
+
+973
+01:33:07,000 --> 01:33:13,700
+كثير، فلنا إذا في حد عنده أسئلة في group الـ
+
+974
+01:33:13,700 --> 01:33:19,910
+WhatsApp، برضه بيحط الواحد إذا بده أسئلة اسأله، أنا
+
+975
+01:33:19,910 --> 01:33:24,090
+مبسوط اليوم إنه إذا في أسئلة، وحتى نشرح ببطء، مش
+
+976
+01:33:24,090 --> 01:33:28,690
+حريص على إنه أخلص كل شيء، يعني يمكن في فصول نقدر
+
+977
+01:33:28,690 --> 01:33:34,250
+نشير إليها إشارة بسيطة، عادي، بقدر ما إنه في أشياء
+
+978
+01:33:34,250 --> 01:33:39,970
+مفاهيم أهم يعني، وممكن تجمعوا الأسئلة سواء يعني
+
+979
+01:33:39,970 --> 01:33:43,250
+خلال المحاضرات أو في بداية أي محاضرة، يعني الدكتور
+
+980
+01:33:43,250 --> 01:33:46,650
+بيترك فرصة لكم تسألوا سواء بالصوت، سواء بالنص
+
+981
+01:33:46,650 --> 01:33:50,590
+كتابة، زي ما بتحبوا، بتسألوا في بداية كل محاضرة أو
+
+982
+01:33:50,590 --> 01:33:54,370
+في نص المحاضرة، يعني الأمر متروك لكم بكل الحرية
+
+983
+01:33:54,370 --> 01:33:57,970
+إن شاء الله، الله يعطيكم العافية، والله يرضى
+
+984
+01:33:57,970 --> 01:34:01,780
+عليكم، ونشوفكم على خير، بعد إذنكم، سامحونا على التعب
+
+985
+01:34:01,780 --> 01:34:03,580
+يا دكتور، يعطيكم الفعالية، لا لا، ليس تعب، أنا
+
+986
+01:34:03,580 --> 01:34:09,760
+والله أتشرف أني أشترك معاكم، والله يوفقكم، يعطيكم
+
+987
+01:34:09,760 --> 01:34:11,880
+الفعالية، وإحنا والله أكثر زادنا الشرف يا دكتور،
+
+988
+01:34:11,880 --> 01:34:15,160
+والله يكفي، الله يحيط، الله يحيط، يلا السلام عليكم
+
+989
+01:34:15,160 --> 01:34:15,960
+في رعاية الله
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/K4hCcRDLuUY_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/K4hCcRDLuUY_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..3fb9b0929565ab3a78c2cb728936797b00c38aed
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/K4hCcRDLuUY_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2688, "start": 0.0, "end": 26.88, "text": "بحب إنه الواحد مننا يكون بهنه صورة كاملة وهيك يحاول يفهم إحنا بنحاول شو نقول أو شو ندرس أو شو نتعامل الآن الوراثة بتعتمد على إن الـDNA اللي اتكلمنا عنه اللي هو أساس في تكون البروتين", "tokens": [3555, 5016, 3555, 36145, 3224, 2423, 14407, 24401, 9154, 8315, 7251, 30544, 4724, 3224, 1863, 3224, 20328, 13063, 3660, 9122, 10943, 37977, 37037, 1829, 4117, 7251, 5016, 995, 12610, 7251, 5172, 16095, 11933, 5016, 8315, 44945, 5016, 995, 12610, 13412, 2407, 8717, 39648, 34051, 13412, 2407, 8717, 3215, 2288, 3794, 34051, 13412, 2407, 8717, 2655, 3615, 10943, 1211, 6024, 48506, 2423, 13063, 5718, 104, 3660, 39894, 34268, 2304, 3215, 15844, 36145, 2423, 39184, 35, 5321, 13672, 1829, 1975, 2655, 4117, 19528, 8315, 18871, 3224, 13672, 1829, 31439, 5551, 3794, 32277, 8978, 6055, 30544, 2423, 26890, 35473, 9957], "avg_logprob": -0.12268813631060171, "compression_ratio": 1.7513513513513514, "no_speech_prob": 6.556510925292969e-07, "words": [{"start": 0.0, "end": 1.08, "word": "بحب", "probability": 0.800537109375}, {"start": 1.08, "end": 1.62, "word": " إنه", "probability": 0.691162109375}, {"start": 1.62, "end": 2.8, "word": " الواحد", "probability": 0.9547526041666666}, {"start": 2.8, "end": 3.32, "word": " مننا", "probability": 0.72119140625}, {"start": 3.32, "end": 4.22, "word": " يكون", "probability": 0.9853515625}, {"start": 4.22, "end": 5.78, "word": " بهنه", "probability": 0.67486572265625}, {"start": 5.78, "end": 6.96, "word": " صورة", "probability": 0.9876302083333334}, {"start": 6.96, "end": 7.42, "word": " كاملة", "probability": 0.9202473958333334}, {"start": 7.42, "end": 8.88, "word": " وهيك", "probability": 0.6558024088541666}, {"start": 8.88, "end": 9.46, "word": " يحاول", "probability": 0.943359375}, {"start": 9.46, "end": 10.32, "word": " يفهم", "probability": 0.9930013020833334}, {"start": 10.32, "end": 10.78, "word": " إحنا", "probability": 0.8408203125}, {"start": 10.78, "end": 11.3, "word": " بنحاول", "probability": 0.9591064453125}, {"start": 11.3, "end": 11.52, "word": " شو", "probability": 0.84619140625}, {"start": 11.52, "end": 11.98, "word": " نقول", "probability": 0.99267578125}, {"start": 11.98, "end": 12.18, "word": " أو", "probability": 0.98046875}, {"start": 12.18, "end": 12.36, "word": " شو", "probability": 0.989013671875}, {"start": 12.36, "end": 12.8, "word": " ندرس", "probability": 0.99072265625}, {"start": 12.8, "end": 12.94, "word": " أو", "probability": 0.99072265625}, {"start": 12.94, "end": 13.12, "word": " شو", "probability": 0.99462890625}, {"start": 13.12, "end": 13.74, "word": " نتعامل", "probability": 0.99189453125}, {"start": 13.74, "end": 16.98, "word": " الآن", "probability": 0.6507568359375}, {"start": 16.98, "end": 18.48, "word": " الوراثة", "probability": 0.95146484375}, {"start": 18.48, "end": 19.24, "word": " بتعتمد", "probability": 0.9715576171875}, {"start": 19.24, "end": 19.76, "word": " على", "probability": 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البروتينات وهو موجود بشكل متساوي في الغالب يعني كل الخلايا، ما عدا الخلايا الجنسية ويكون الخلايا بتقوم بطريقة دقيقة جداً بعملية تكرار الـDNA حيث إنه دايماً", "tokens": [2407, 3224, 2407, 9673, 3794, 19986, 12610, 18871, 6055, 4117, 2407, 9957, 2423, 26890, 35473, 9957, 9307, 37037, 2407, 3714, 29245, 23328, 4724, 8592, 28820, 44650, 3794, 995, 45865, 8978, 6024, 118, 6027, 3555, 37495, 22653, 28242, 33962, 15040, 25528, 12399, 19446, 6225, 28259, 33962, 15040, 25528, 25724, 1863, 3794, 10632, 4032, 1829, 30544, 33962, 15040, 25528, 39894, 4587, 20498, 4724, 9566, 16572, 28671, 11778, 38436, 28671, 10874, 28259, 14111, 4724, 25957, 1211, 10632, 6055, 37983, 9640, 2423, 39184, 35, 5321, 11331, 1829, 12984, 36145, 3224, 11778, 47302, 15042, 14111], "avg_logprob": -0.13315590855839488, "compression_ratio": 1.7391304347826086, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 28.01, "end": 28.37, "word": "وهو", "probability": 0.9822591145833334}, {"start": 28.37, "end": 28.85, 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807.57, "end": 835.17, "text": "وهذه الـ Direction of Transcription لحد ما يصل بالأخير إلى الـ Termination Codon اللي يقول له واقف هنا وبعدين حتى يحميه ويمشي خطوات أخرى بيكون فيه Untranslated Region و Polyadenylation Signal وفي أشياء إضافية حتى تساعد في عملية التحكم", "tokens": [2407, 3224, 24192, 2423, 39184, 5822, 882, 295, 6531, 12432, 5296, 24401, 19446, 7251, 36520, 20666, 10721, 9778, 13546, 30731, 2423, 39184, 19835, 2486, 383, 378, 266, 13672, 1829, 7251, 39648, 46740, 36764, 4587, 5172, 34105, 46599, 22488, 9957, 11331, 49975, 7251, 35571, 1829, 3224, 4032, 32640, 8592, 1829, 16490, 9566, 2407, 9307, 5551, 34740, 7578, 4724, 1829, 30544, 8978, 3224, 8256, 25392, 38539, 25121, 4032, 18553, 14771, 5088, 399, 43414, 4032, 41185, 5551, 8592, 1829, 16606, 11933, 11242, 31845, 10632, 11331, 49975, 6055, 3794, 995, 22488, 8978, 6225, 42213, 10632, 16712, 5016, 24793], "avg_logprob": -0.1523026300104041, "compression_ratio": 1.4210526315789473, "no_speech_prob": 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{"start": 2803.43, "end": 2804.65, "word": " A1", "probability": 0.915771484375}, {"start": 2804.65, "end": 2804.81, "word": " و", "probability": 0.986328125}, {"start": 2804.81, "end": 2805.39, "word": " A2", "probability": 0.945556640625}, {"start": 2805.39, "end": 2806.61, "word": " كجين", "probability": 0.9427083333333334}, {"start": 2806.61, "end": 2807.49, "word": " آه", "probability": 0.7373046875}, {"start": 2807.49, "end": 2807.73, "word": " كلها", "probability": 0.898681640625}, {"start": 2807.73, "end": 2808.01, "word": " فيها", "probability": 0.994384765625}, {"start": 2808.01, "end": 2808.35, "word": " الجين", "probability": 0.937255859375}, {"start": 2808.35, "end": 2808.67, "word": " هذا", "probability": 0.94580078125}, {"start": 2808.67, "end": 2809.91, "word": " والجينات", "probability": 0.82080078125}, {"start": 2809.91, "end": 2810.21, "word": " هذه", "probability": 0.91357421875}], "temperature": 1.0}, {"id": 104, "seek": 283974, "start": 2810.9, "end": 2839.74, "text": "بس في مرحلة معينة، في حياة معينة، في ظرف معين بيصير فيه داعي لإيش محدد فبيتم إنتاجه أو بيتم تشغيله أو بيتم، بيقول سويًا لما نقول عن الـDNA بيصير الـTranscription تبعه عشان يعطينا الـMessenger RNA عشان يعطينا الـProtein تبعه حتى تقدر الوظيفة المطلوبة فلما أنا أشوف الـProtein طلع", "tokens": [3555, 3794, 8978, 3714, 2288, 5016, 37977, 20449, 9957, 3660, 12399, 8978, 11331, 25528, 3660, 20449, 9957, 3660, 12399, 8978, 1357, 116, 28480, 20449, 9957, 4724, 1829, 9381, 13546, 8978, 3224, 11778, 45761, 1829, 5296, 28814, 1829, 8592, 3714, 24401, 3215, 6156, 21292, 39237, 11933, 29399, 26108, 3224, 34051, 4724, 36081, 2304, 6055, 8592, 17082, 26895, 3224, 34051, 4724, 36081, 2304, 12399, 4724, 1829, 39648, 8608, 45865, 14111, 995, 5296, 15042, 8717, 39648, 18871, 2423, 39184, 35, 5321, 4724, 1829, 9381, 13546, 2423, 39184, 33339, 12432, 6055, 3555, 3615, 3224, 6225, 8592, 7649, 37495, 9566, 1829, 8315, 2423, 39184, 44, 442, 10210, 22484, 6225, 8592, 7649, 37495, 9566, 1829, 8315, 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0.987548828125}, {"start": 3128.59, "end": 3128.77, "word": " هون", "probability": 0.49072265625}, {"start": 3128.77, "end": 3129.17, "word": " الظاهرة", "probability": 0.7977294921875}, {"start": 3129.17, "end": 3129.29, "word": " اللي", "probability": 0.991943359375}, {"start": 3129.29, "end": 3129.51, "word": " بديوا", "probability": 0.5517578125}, {"start": 3129.51, "end": 3129.99, "word": " يحكوها", "probability": 0.968359375}, {"start": 3129.99, "end": 3131.07, "word": " أنه", "probability": 0.7294921875}, {"start": 3131.07, "end": 3132.29, "word": " أصل", "probability": 0.645263671875}, {"start": 3132.29, "end": 3132.59, "word": " أن", "probability": 0.62744140625}, {"start": 3132.59, "end": 3132.79, "word": " الـ", "probability": 0.92919921875}, {"start": 3132.79, "end": 3133.19, "word": " Promoter", "probability": 0.85400390625}, {"start": 3133.19, "end": 3133.59, "word": " Region", "probability": 0.95068359375}, {"start": 3133.59, "end": 3133.91, "word": " إحنا", 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فيه كروموزوم", "tokens": [6027, 20292, 39896, 2423, 39184, 6481, 266, 383, 378, 266, 24976, 3555, 28259, 10632, 6156, 6027, 39184, 15833, 21585, 4791, 626, 5551, 5016, 1829, 7649, 14111, 995, 12174, 3215, 6055, 30544, 11933, 1829, 8592, 13672, 1829, 39896, 25724, 11622, 38207, 9673, 3555, 33599, 2288, 36725, 5016, 1829, 7649, 14111, 995, 39894, 30544, 9154, 9566, 28671, 45030, 25708, 3660, 36725, 5016, 1829, 7649, 14111, 995, 30767, 1829, 19446, 11331, 41193, 9957, 34105, 9154, 5296, 3794, 3224, 6156, 2655, 27884, 38637, 7649, 10632, 37495, 22653, 37495, 22653, 30767, 1829, 19446, 8032, 2304, 11331, 41193, 9957, 34105, 14739, 3224, 4657, 21454, 5933, 4032, 4657, 21454, 5933, 37495, 22653, 8978, 3224, 9122, 2288, 20498, 2407, 11622, 20498], "avg_logprob": -0.18558113839019807, "compression_ratio": 1.7105263157894737, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 3846.91, "end": 3847.79, "word": "اللي", "probability": 0.5738525390625}, {"start": 3847.79, "end": 3848.01, 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"end": 3880.37, "word": " تبعه", "probability": 0.834716796875}, {"start": 3880.37, "end": 3880.95, "word": " باتحاج", "probability": 0.7415771484375}, {"start": 3880.95, "end": 3881.45, "word": " لقطع", "probability": 0.9352213541666666}, {"start": 3881.45, "end": 3882.01, "word": " ثاني", "probability": 0.78759765625}, {"start": 3882.01, "end": 3882.65, "word": " من", "probability": 0.93359375}, {"start": 3882.65, "end": 3884.77, "word": " خيط", "probability": 0.9552408854166666}, {"start": 3884.77, "end": 3885.39, "word": " ثاني", "probability": 0.9892578125}, {"start": 3885.39, "end": 3886.39, "word": " موجود", "probability": 0.9768880208333334}, {"start": 3886.39, "end": 3887.31, "word": " جنبه،", "probability": 0.90498046875}, {"start": 3887.31, "end": 3887.45, "word": " بس", "probability": 0.908447265625}, {"start": 3887.45, "end": 3887.73, "word": " لازم", "probability": 0.9876302083333334}, {"start": 3887.73, "end": 3887.99, "word": " يكون", "probability": 0.989013671875}, 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نشير إليها إشارة بسيطة عادرة بقدر ما إنه في أشياء مفاهيم أهم يعني", "tokens": [3555, 43042, 3224, 4724, 1829, 5016, 9566, 2423, 14407, 24401, 11933, 15730, 47525, 3224, 5551, 3794, 19986, 37977, 24525, 10721, 43761, 41850, 3714, 3555, 3794, 2407, 9566, 45595, 20498, 36145, 3224, 11933, 15730, 8978, 5551, 3794, 19986, 37977, 4032, 33753, 7578, 8717, 46309, 5016, 4724, 3555, 9566, 38207, 37893, 11331, 16572, 9381, 15844, 36145, 3224, 5551, 9778, 1211, 9381, 28242, 44049, 38207, 37495, 22653, 7251, 43020, 8978, 6156, 9381, 12610, 8717, 28543, 2288, 8717, 8592, 13546, 11933, 20292, 11296, 11933, 8592, 9640, 3660, 4724, 3794, 1829, 9566, 3660, 6225, 18513, 25720, 4724, 28543, 2288, 19446, 36145, 3224, 8978, 5551, 8592, 1829, 16606, 3714, 5172, 40294, 32640, 5551, 16095, 37495, 22653], "avg_logprob": -0.09642454619343216, "compression_ratio": 1.7783251231527093, "no_speech_prob": 5.4836273193359375e-06, "words": [{"start": 5596.27, "end": 5596.75, "word": "برضه", "probability": 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{"id": 209, "seek": 565596, "start": 5640.92, "end": 5655.96, "text": "سامحنا على الغلب يا دكتور، يعطينا الفعالية لا، لا، ليس غلب، أنا والله أتشرف أني أشترك معاكم، و الله يوفقكم، يعطينا الفعالية وإحنا والله أكثر زادنا الشرف يا دكتور، والله يكفي الله يحيط، الله يحيط، يلا السلام عليكم في رعاية الله", "tokens": [3794, 10943, 5016, 8315, 15844, 6024, 118, 46152, 35186, 11778, 4117, 2655, 13063, 12399, 37495, 9566, 1829, 8315, 27188, 3615, 6027, 10632, 20193, 12399, 20193, 12399, 32239, 3794, 32771, 46152, 12399, 41850, 16070, 43761, 5551, 2655, 8592, 28480, 14739, 1829, 5551, 8592, 2655, 31747, 20449, 995, 24793, 12399, 4032, 21984, 7251, 38688, 4587, 24793, 12399, 37495, 9566, 1829, 8315, 27188, 3615, 6027, 10632, 4032, 28814, 5016, 8315, 16070, 43761, 5551, 4117, 49115, 30767, 18513, 8315, 25124, 28480, 35186, 11778, 4117, 2655, 13063, 12399, 16070, 43761, 7251, 4117, 41185, 21984, 7251, 5016, 1829, 9566, 12399, 21984, 7251, 5016, 1829, 9566, 12399, 7251, 15040, 21136, 37440, 25894, 24793, 8978, 12602, 3615, 995, 10632, 21984], "avg_logprob": -0.2895464559571933, "compression_ratio": 2.227027027027027, "no_speech_prob": 7.152557373046875e-07, "words": [{"start": 5640.92, "end": 5641.44, "word": "سامحنا", "probability": 0.66107177734375}, {"start": 5641.44, "end": 5641.56, "word": " على", "probability": 0.85107421875}, {"start": 5641.56, "end": 5641.78, "word": " الغلب", "probability": 0.9645182291666666}, {"start": 5641.78, "end": 5641.9, "word": " يا", "probability": 0.87841796875}, {"start": 5641.9, "end": 5642.36, "word": " دكتور،", "probability": 0.833251953125}, {"start": 5642.36, "end": 5642.64, "word": " يعطينا", "probability": 0.8089599609375}, {"start": 5642.64, "end": 5642.86, "word": " الفعالية", "probability": 0.554473876953125}, {"start": 5642.86, "end": 5642.88, "word": " لا،", "probability": 0.29107666015625}, {"start": 5642.88, "end": 5642.92, "word": " لا،", "probability": 0.7802734375}, {"start": 5642.92, "end": 5643.0, "word": " ليس", "probability": 0.5205078125}, {"start": 5643.0, "end": 5643.38, "word": " غلب،", "probability": 0.7766927083333334}, {"start": 5643.38, "end": 5643.58, "word": " أنا", "probability": 0.7080078125}, {"start": 5643.58, "end": 5644.08, "word": " والله", "probability": 0.81298828125}, {"start": 5644.08, "end": 5646.06, "word": " أتشرف", "probability": 0.9180908203125}, {"start": 5646.06, "end": 5646.58, "word": " أني", "probability": 0.590576171875}, {"start": 5646.58, "end": 5647.12, "word": " أشترك", "probability": 0.9744873046875}, {"start": 5647.12, "end": 5647.84, "word": " معاكم،", "probability": 0.853515625}, {"start": 5647.84, "end": 5647.9, "word": " و", "probability": 0.833984375}, {"start": 5647.9, "end": 5648.06, "word": " الله", "probability": 0.755859375}, {"start": 5648.06, "end": 5649.44, "word": " يوفقكم،", "probability": 0.666650390625}, {"start": 5649.44, "end": 5649.76, "word": " يعطينا", "probability": 0.918701171875}, {"start": 5649.76, "end": 5649.76, "word": " الفعالية", "probability": 0.81573486328125}, {"start": 5649.76, "end": 5650.06, "word": " وإحنا", "probability": 0.6793212890625}, {"start": 5650.06, "end": 5650.36, "word": " والله", "probability": 0.779052734375}, {"start": 5650.36, "end": 5650.74, "word": " أكثر", "probability": 0.95751953125}, {"start": 5650.74, "end": 5651.08, "word": " زادنا", "probability": 0.921875}, {"start": 5651.08, "end": 5651.38, "word": " الشرف", "probability": 0.991943359375}, {"start": 5651.38, "end": 5651.52, "word": " يا", "probability": 0.9326171875}, {"start": 5651.52, "end": 5651.88, "word": " دكتور،", "probability": 0.97646484375}, {"start": 5651.88, "end": 5652.18, "word": " والله", "probability": 0.82470703125}, {"start": 5652.18, "end": 5652.38, "word": " يكفي", "probability": 0.469482421875}, {"start": 5652.38, "end": 5652.54, "word": " الله", "probability": 0.447265625}, {"start": 5652.54, "end": 5653.02, "word": " يحيط،", "probability": 0.779833984375}, {"start": 5653.02, "end": 5653.18, "word": " الله", "probability": 0.8095703125}, {"start": 5653.18, "end": 5653.78, "word": " يحيط،", "probability": 0.98955078125}, {"start": 5653.78, "end": 5654.04, "word": " يلا", "probability": 0.67236328125}, {"start": 5654.04, "end": 5654.4, "word": " السلام", "probability": 0.75048828125}, {"start": 5654.4, "end": 5655.16, "word": " عليكم", "probability": 0.799560546875}, {"start": 5655.16, "end": 5655.48, "word": " في", "probability": 0.71533203125}, {"start": 5655.48, "end": 5655.78, "word": " رعاية", "probability": 0.9771728515625}, {"start": 5655.78, "end": 5655.96, "word": " الله", "probability": 0.96728515625}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 5662.6968125, "duration_after_vad": 5537.4259687500235}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/KblmxBN0mak_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/KblmxBN0mak_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..e42bb931cb648d2151ea86cab2fc69295e4ddf06
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/KblmxBN0mak_raw.srt
@@ -0,0 +1,2828 @@
+1
+00:00:00,930 --> 00:00:08,650
+خلّيني عشان أعمل share فيه
+
+2
+00:00:08,650 --> 00:00:15,430
+ابتدان، فيه أسئلة من المحاضرة
+
+3
+00:00:15,430 --> 00:00:25,890
+السابقة حد عنده أي ملاحظات يعني
+
+4
+00:00:25,890 --> 00:00:37,990
+احنا المحاضرة اللي فاتتبدأنا نحكي عن الأمثلة
+
+5
+00:00:37,990 --> 00:00:45,770
+الأقوى والأشد من أنواع الأمراض الوراثة وبكون إنه
+
+6
+00:00:45,770 --> 00:00:53,310
+قطعة كروموزوم كاملة أو جزء منها، قطعة كبيرةبتم إن
+
+7
+00:00:53,310 --> 00:00:59,150
+يكون فيها خلل سواء وعرفنا إنه ممكن تنحدث ممكن
+
+8
+00:00:59,150 --> 00:01:05,870
+تتكرر، تتزداد، تتقل، تتغير، كذا وإنه بدأنا نحكي عن
+
+9
+00:01:05,870 --> 00:01:13,970
+الأمثلة على هذا الموضوع في حد عنده أسئلة؟ أهم
+
+10
+00:01:13,970 --> 00:01:19,950
+ميكانزماللي هو Abnormal Chromosomal Segregation
+
+11
+00:01:19,950 --> 00:01:23,950
+اللي هي قضية الـNon-Disjunction يعني أنه لما كان
+
+12
+00:01:23,950 --> 00:01:28,190
+الكرومزومين جانب بعض لما ييجي في الـMetaphase في
+
+13
+00:01:28,190 --> 00:01:35,570
+قضية الـCell Division ينفصلوا لنصين متساويين بتكون
+
+14
+00:01:35,570 --> 00:01:40,270
+الإنقسام بشكل غير متساوي فالجهة بتكون فيها زيادة
+
+15
+00:01:40,270 --> 00:01:45,990
+وجهة بتكون فيها نقصان فهذا الـ… يعني هذه الظاهرة
+
+16
+00:01:48,480 --> 00:01:55,320
+يعني بالذات إذا حدثت وكانت فقط موجودة وبحيث أنه
+
+17
+00:01:55,320 --> 00:02:02,880
+بيقولها إنه كمية الـ DNA متوازنة في الشخص راح يكون
+
+18
+00:02:02,880 --> 00:02:07,800
+في الغالب ما إلها مشكلة عنده بقدر ما إنه في ذريته
+
+19
+00:02:07,800 --> 00:02:12,720
+في البروجينيت تبعه لما تحتاج هذه الخلايا تنقسم
+
+20
+00:02:12,720 --> 00:02:18,770
+برضه راح يصير فيها مشكلةوتكلمنا عن Trisomy 21 اللي
+
+21
+00:02:18,770 --> 00:02:24,390
+هو الـ Down Syndrome وحكينا ارتباطه بكبر عمر الأم
+
+22
+00:02:24,390 --> 00:02:30,470
+بالذات وكيف أحيانًا أنه بيكون عبارة عن حتى لما أجي
+
+23
+00:02:30,470 --> 00:02:38,230
+أعده كـ Trisomy 21 بلاقي لأ مافيش نسخة زايدة إنما
+
+24
+00:02:38,230 --> 00:02:45,340
+نسخة زايدة شابقة على كروموزوم 14فهي Translocation
+
+25
+00:02:45,340 --> 00:02:48,420
+من
+
+26
+00:02:48,420 --> 00:02:54,540
+الأمثلة على جزء
+
+27
+00:02:54,540 --> 00:03:01,220
+من الـ DNA اللي هي موضوع الـ Dijord Syndrome
+
+28
+00:03:01,730 --> 00:03:07,230
+بالنسبة للـ Die George Syndrome خلّينا نفرجيكم
+
+29
+00:03:07,230 --> 00:03:19,430
+الصورة هذه Die George Syndrome images
+
+30
+00:03:19,430 --> 00:03:25,370
+هذه
+
+31
+00:03:25,370 --> 00:03:28,410
+Save images
+
+32
+00:03:48,020 --> 00:03:55,700
+الـ Dijord Syndrome الـ
+
+33
+00:03:55,700 --> 00:03:59,900
+Dijord
+
+34
+00:03:59,900 --> 00:04:09,180
+Syndrome هو عبارة عنالـ Chromosome برضه 22 اللي هو
+
+35
+00:04:09,180 --> 00:04:19,760
+يعني الـ Chromosome 22 segment 11.2 إبارة عن قطعة
+
+36
+00:04:19,760 --> 00:04:29,790
+بتكون فيها اختلال فالـ Digort Syndromeحكينا نتيجة
+
+37
+00:04:29,790 --> 00:04:35,290
+اختلال هذه
+
+38
+00:04:35,290 --> 00:04:38,910
+القطعة بيصير خلل في الـ third و fourth pharyngeal
+
+39
+00:04:38,910 --> 00:04:44,470
+pouches تبعات الـ embryogenesis اللي هم المرحلة
+
+40
+00:04:44,470 --> 00:04:50,230
+المضغة في خلق الإنسان اللي هي محل ما كأنه قطعة
+
+41
+00:04:50,230 --> 00:04:53,690
+البان مأكولة هيك الإنسان بيكون في مرحلة معينة
+
+42
+00:04:54,160 --> 00:04:56,340
+الثالث والأربعاء هي الـ Pouches الفرنجية التي
+
+43
+00:04:56,340 --> 00:05:04,620
+تعطينا الـ Thymus وفيها تتم التطور والتكوين والـ T
+
+44
+00:05:04,620 --> 00:05:10,040
+-cells والمناعةالمتخصصة للخلوية فبالتالي بيصير
+
+45
+00:05:10,040 --> 00:05:14,020
+عندنا نقصان مناعة بيكون عندنا congenital heart
+
+46
+00:05:14,020 --> 00:05:17,840
+disease وبيكون عندنا hyperparathyroidism،
+
+47
+00:05:17,840 --> 00:05:20,960
+hypoparathyroidism وhypocalcemia لأن الـ
+
+48
+00:05:20,960 --> 00:05:25,140
+adrenaline الـ hypoparathyroid glands تطلع من الـ
+
+49
+00:05:25,140 --> 00:05:28,320
+third والfourth pharyngeal pouches فما بيكون عندهم
+
+50
+00:05:28,320 --> 00:05:35,880
+بالأخير الصورة هذه هي لطفل عندهده الـ Dijort
+
+51
+00:05:35,880 --> 00:05:42,280
+Syndrome أولاً، الذنين كما تشاهدون نزلت لأسفل
+
+52
+00:05:42,280 --> 00:05:49,500
+فبيسموها Lost Ears وIncreased Philtrum اللي هو
+
+53
+00:05:49,500 --> 00:05:57,500
+المسافة ما بين طرف الأنف وطرف الشفة بتلاقيها مسافة
+
+54
+00:05:57,500 --> 00:06:02,980
+طويلة وبيسموها Increased Philtrum وهي من المظاهر
+
+55
+00:06:02,980 --> 00:06:10,890
+اللي هيالـ Dijard Syndrome ممكن الواحد لما نيجي
+
+56
+00:06:10,890 --> 00:06:17,730
+يدور عليهم ده مش كرموزوم كامل باخد اللي بيسموه
+
+57
+00:06:17,730 --> 00:06:23,870
+Microarray و لا باخد الـ Fish اللي هو Fluorescence
+
+58
+00:06:23,870 --> 00:06:30,390
+in Cytohybridization يعني باخد الواحد عبارة عن
+
+59
+00:06:30,390 --> 00:06:40,160
+آلية حتى يدورعليها في الأمراض الأمراض الثانية ما
+
+60
+00:06:40,160 --> 00:06:44,080
+بدنا شيها بعدين
+
+61
+00:06:44,080 --> 00:06:49,900
+بدنا ندخل على six chromosomes وحكينا في الـ X والـ
+
+62
+00:06:49,900 --> 00:06:58,580
+Y chromosomes التعقيد مظهر الإنسان الجنسي كذكر أو
+
+63
+00:06:58,580 --> 00:07:08,350
+أنثى بتتم من خلال ثلاثمراحل المرحلة الأولى حكينا
+
+64
+00:07:08,350 --> 00:07:13,450
+عنها هي الـ Chromosomes وما هي الجينات اللي عندها
+
+65
+00:07:13,450 --> 00:07:21,130
+ومسؤول عن التحكم في أشياء معينة الجينات هذه والـ
+
+66
+00:07:21,130 --> 00:07:26,750
+Chromosomes الـ X والـ Y بتأثر على الأعضاء
+
+67
+00:07:26,750 --> 00:07:33,770
+التناسلية الـ Testicles والـ Ovariesوبتأثر عليها
+
+68
+00:07:33,770 --> 00:07:39,330
+في تطورها بيأثر عليها في وظيفتها بيأثر عليها في
+
+69
+00:07:39,330 --> 00:07:45,050
+قضية إفرازها للـHormones ونشاطها بشكل اللازم
+
+70
+00:07:45,050 --> 00:07:50,310
+والطبيعي بحيث إنه بالأخير بيعطينا المظهر الخارجي
+
+71
+00:07:50,310 --> 00:07:57,070
+لرجل أو امرأة ذكر أو أنثى بهذا الشكلالمرحلة
+
+72
+00:07:57,070 --> 00:08:04,710
+الأخيرة مهمة في تطور الجنس للإنسان قضية البيئة
+
+73
+00:08:04,710 --> 00:08:10,970
+اللي هو موجود فيها يعني قضية الترباية، قضية
+
+74
+00:08:10,970 --> 00:08:14,130
+التعليم
+
+75
+00:08:14,130 --> 00:08:19,180
+على سلوك معيندائماً بيقولوا يعني ولد صغير بتلاقي
+
+76
+00:08:19,180 --> 00:08:25,360
+وقع بعيط بيقولوا إيه؟ بتعيط؟ أنت زلمة، كيف اتعيط؟
+
+77
+00:08:25,360 --> 00:08:29,820
+ماصيرش اتعيط؟ كده يعني بتلاقيه بأثر عليه بشكل
+
+78
+00:08:29,820 --> 00:08:37,460
+بيخليه يتصرف بشكل معين فبالنسبة للتطور الجنسي
+
+79
+00:08:37,460 --> 00:08:45,020
+بالنسبة للـ X وY كرموزومات هذه ناحية مهمة كثيرةالـ
+
+80
+00:08:45,020 --> 00:08:48,780
+Y-Chromosome بشكل عام مافيش فيه عدد كبير من
+
+81
+00:08:48,780 --> 00:08:57,800
+الجينات يعني قطعة صغيرة وبتلاقي فيها يعني عدد قليل
+
+82
+00:08:57,800 --> 00:09:02,780
+من الـ من الجينات وحجمه صغير
+
+83
+00:09:06,840 --> 00:09:12,960
+التراكيب الجنسي عند الإبشر في الـ Embryogenesis
+
+84
+00:09:12,960 --> 00:09:20,860
+بتمر فترة بيكون عند الإنسان التراكيب مشتركة وبيكون
+
+85
+00:09:20,860 --> 00:09:26,520
+التراكيب ذكرية وأنثوية ففي بارة Mesonephric duct
+
+86
+00:09:26,520 --> 00:09:33,840
+وMesonephric ductوالـ Ambiguant أو Ambipotent
+
+87
+00:09:33,840 --> 00:09:41,860
+Guenade يعني هذه قصية أو مبيض مستعدة تكون أي نوع
+
+88
+00:09:41,860 --> 00:09:48,200
+وبتكون جاهزة أن تتوجه هيك أو تتوجه هيك فوهنا
+
+89
+00:09:48,200 --> 00:09:54,320
+التراكيب الجنسية الداخلية ترتبط بالتراكيب الجنسية
+
+90
+00:09:54,320 --> 00:10:03,040
+الخارجيةأهم عامل حتى يتم التوجيه باتجاه أن يكون
+
+91
+00:10:03,040 --> 00:10:10,080
+هناك ذكر هو وجود الـ Y-Chromosome وعدم وجوده يجعل
+
+92
+00:10:10,080 --> 00:10:15,980
+الأجهزة والـ Development تتوجه باتجاه الـ Female،
+
+93
+00:10:15,980 --> 00:10:21,090
+يعني هذه ناحية مهمةفإذا كان فيه Y-Chromosome بنتج
+
+94
+00:10:21,090 --> 00:10:26,070
+عنه أنه تتحول لقصية Testicles وSpermatogenesis
+
+95
+00:10:26,070 --> 00:10:31,090
+وفيه Androgens زي التستيرون وبعطينا الـ Male
+
+96
+00:10:31,090 --> 00:10:35,010
+Internal و External Genitalia وCharacteristics إذا
+
+97
+00:10:35,010 --> 00:10:40,370
+ما فيه، الأمور باتجاهنا تكون Female، فهذه ناحية
+
+98
+00:10:40,370 --> 00:10:41,070
+مهمة
+
+99
+00:10:44,550 --> 00:10:52,130
+بالنسبة لـ … يعني هناك اختلالات أوبتحدث دواهر
+
+100
+00:10:52,130 --> 00:10:59,990
+كثيرة في هذا الأمر ماشي بس النقطة المهمة أنه يعني
+
+101
+00:10:59,990 --> 00:11:03,890
+الأهم هو الـ X-Chromosome الـ X-Chromosome عليه
+
+102
+00:11:03,890 --> 00:11:09,970
+عدد كبير من الجينات مسؤول عنه كثير من التكون وفي
+
+103
+00:11:09,970 --> 00:11:17,230
+أشياء كثيرة عليه يعني يمكن 1500 جين يعني فبالنسبة
+
+104
+00:11:17,230 --> 00:11:24,210
+للـ X-Chromosomeشوما كان عدد النسخ تبع الـ X
+
+105
+00:11:24,210 --> 00:11:28,570
+-Chromosome واحد منها فقط هو الشغال الـ Active
+
+106
+00:11:28,570 --> 00:11:33,930
+بيكون راح يكون Active والبقية راح تكون نسميهم Par
+
+107
+00:11:33,930 --> 00:11:40,510
+Bodies وInactive وانا حاطين أمثلة إن هاي الـ
+
+108
+00:11:40,510 --> 00:11:46,210
+Normal Female أول واحدةاللي احنا شايفينه هو 46
+
+109
+00:11:46,210 --> 00:11:51,690
+كروموزوم زي ما نعمله كاريو تايب وكان XX فبهذا
+
+110
+00:11:51,690 --> 00:11:58,290
+الشكل فيه هناك بيسموها super female ممكن تلاقي شخص
+
+111
+00:11:58,290 --> 00:12:01,730
+أو أنثى عندها 47 كروموزوم
+
+112
+00:12:05,010 --> 00:12:09,610
+الأصليات اللي هم الأربعة واثنين وعشرين pair زائد
+
+113
+00:12:09,610 --> 00:12:18,230
+XXX أو XXXX أو XX يعني حتى أربع نسخة من inactive
+
+114
+00:12:18,230 --> 00:12:27,170
+form of X-chromosome فلو كان مثلًافي الـ Male
+
+115
+00:12:27,170 --> 00:12:31,850
+مظهريًا اللي بيسموه «تيرنر سندروم» بتلاقوا عندها
+
+116
+00:12:31,850 --> 00:12:38,250
+45XO الـ O يعني مافيش عندها نسخة ثانية فبلاقي لما
+
+117
+00:12:38,250 --> 00:12:44,230
+نعمل دراسة بهذا الشكل كـ Karyotype أو عشان ندور
+
+118
+00:12:44,230 --> 00:12:48,430
+على الـ Inactive X-Chromosome نلاقي فيه صفر، مافيش
+
+119
+00:12:48,430 --> 00:12:54,110
+فيه نفس الظاهرة ممكن تحدث في الـ Males عادةً الـ
+
+120
+00:12:54,110 --> 00:13:00,710
+Male أهم جانببشكل طبيعي أنه وجود الـ Y ما ندخل عدد
+
+121
+00:13:00,710 --> 00:13:13,330
+نسخ الـ X ماشي في أسئلة هنا بقولكم بالنسبة لنتوقع
+
+122
+00:13:13,330 --> 00:13:20,710
+يعني كيف بالنسبة لغربية الـ Females راح نلاقي أنه
+
+123
+00:13:21,290 --> 00:13:28,770
+في كل خلية أو مجموعة خلايا بتلاقي أحد نسختين الـ X
+
+124
+00:13:28,770 --> 00:13:33,850
+-Chromosome inactive يا إما الـ X اللي جاي من الأب
+
+125
+00:13:33,850 --> 00:13:39,790
+أو الـ X اللي جاي من الأم فهي يعني أحياناً بتأثر
+
+126
+00:13:39,790 --> 00:13:49,260
+على يعني إذا مثلاً في مرض عند الأبوبتلاقي أو
+
+127
+00:13:49,260 --> 00:13:55,960
+بالعكس يعني مثلًا هناك أنثى حامل لـ Chromosome لـ
+
+128
+00:13:55,960 --> 00:14:00,760
+Gene على الـ X-Chromosome وفيه مرض فإيه الأصل؟
+
+129
+00:14:00,760 --> 00:14:04,880
+بنقول هي حامل وغير مصابة غير مصابة يعني مافيش
+
+130
+00:14:04,880 --> 00:14:10,990
+عندها مشكلةوبكون إذا كان عندها مظهر، بعض مظاهر
+
+131
+00:14:10,990 --> 00:14:15,750
+المشكلة بيكون إنه هاي في الخلايا اللي إن النسخة
+
+132
+00:14:15,750 --> 00:14:19,010
+المضروبة من الـ X هي اللي فاعلة أو هي اللي active
+
+133
+00:14:19,010 --> 00:14:27,370
+فهي أحيانًا ظاهرة بتحدث فيها سؤالة؟
+
+134
+00:14:27,370 --> 00:14:33,070
+الآن بالنسبة
+
+135
+00:14:33,070 --> 00:14:40,310
+للأمراض والمشاكلاللي هي فيه Abnormalities في الـ
+
+136
+00:14:40,310 --> 00:14:44,390
+Sex Chromosome يعني الـ Whole Chromosome Anomaly
+
+137
+00:14:44,390 --> 00:14:50,190
+ففيه مرض اسمه Client Filter البقية بدناشي يعني
+
+138
+00:14:50,190 --> 00:15:03,130
+ناشي ال .. ال .. بالنسبة لـ Client Filterبتلاقي 47
+
+139
+00:15:03,130 --> 00:15:06,690
+كروموزومز
+
+140
+00:15:06,690 --> 00:15:14,170
+الـ Total موجود و44 أو 22 زوج أوتوزامل وبعدين الـ
+
+141
+00:15:14,170 --> 00:15:20,750
+6 كروموزومز في XXY، ماشي؟ هذه تقريبًا واحد في كل
+
+142
+00:15:20,750 --> 00:15:29,330
+600 ذكر حوالي تقريبًا في أحدكم بعتليسؤال، نحفظ
+
+143
+00:15:29,330 --> 00:15:33,430
+الأرقام هذه؟ أنا بقول ما في داعي الواحد يحفظها
+
+144
+00:15:33,430 --> 00:15:39,330
+بقدر ما أنه يعني ينتبه لعلاقاتهم مع بعض اللي هي
+
+145
+00:15:39,330 --> 00:15:46,350
+قضية أنه مثلا أشع مرض اللي هو Climfilter، ماشي؟
+
+146
+00:15:46,350 --> 00:15:52,350
+حوالي واحد في ستمية، ماشي؟ بالـFemales أكثر أشع
+
+147
+00:15:52,350 --> 00:15:57,550
+يشيل هو الـTurner واحد في كل أربع تلاف، ماشي؟
+
+148
+00:15:57,940 --> 00:16:02,000
+فأحيانًا إنك تشوف رقم واحد هيك تنتبهين إن هو رقم
+
+149
+00:16:02,000 --> 00:16:07,960
+واحد ناحية مهمة دكتور في سؤال كريم يتكلم عن الـ
+
+150
+00:16:07,960 --> 00:16:11,800
+Inactivation للـ X بيسأل كيف بيصير، يعني بيسأل عن
+
+151
+00:16:11,800 --> 00:16:17,970
+الـ Mechanismالمطلوب زي ما شُفت في النسخ اللي فيها
+
+152
+00:16:17,970 --> 00:16:25,470
+Bar Bodies إنه في أي خلية واحد من الـ X
+
+153
+00:16:25,470 --> 00:16:31,250
+-Chromosomes هو اللي وحيد اللي شغّال، فبالظبط كيف
+
+154
+00:16:31,250 --> 00:16:37,730
+بحدث؟ ليش بحدث بهذه الطريقة؟ يعني ما، ماعندي يعني
+
+155
+00:16:37,730 --> 00:16:43,510
+تفسير، بقدر ما إنها هي هيك بتحدث هيك ربنا حاططها
+
+156
+00:16:43,510 --> 00:16:54,020
+فينافالآن هذولة أربع إناث ماشي لما نيجي وحاطين هنا
+
+157
+00:16:54,020 --> 00:17:01,260
+صورة لبعدين التوزيع يعني كام لو جبت ألف أنثى أو
+
+158
+00:17:01,260 --> 00:17:06,980
+درست الـ X-Chromosomes تبعينهم حلاق الغالبي العظمى
+
+159
+00:17:06,980 --> 00:17:16,860
+XX وامور تيادية بشكل يعتبرعشوائي، راندوم، يعني مش
+
+160
+00:17:16,860 --> 00:17:22,760
+إشي مقفود، هيك يظن يعني، ماشي الغالبية العظمى راح
+
+161
+00:17:22,760 --> 00:17:29,900
+تلاقوا إنه في واحد فقط من النسخ تبعات الـ X هي
+
+162
+00:17:29,900 --> 00:17:37,720
+النشطة هي الـ Euchromatin بسموها، يعني هي اللي طبة
+
+163
+00:17:37,720 --> 00:17:45,540
+الحبل أو الخيط تبع الـ DNAبدل ما هو مضغوط وقت الـ
+
+164
+00:17:45,540 --> 00:17:50,480
+Cell Division لأ، بيكون فايلت عشان يتم قراءة
+
+165
+00:17:50,480 --> 00:17:56,240
+الجينات اللي عليه فهذا راح يكون نسخة واحدة بس هي
+
+166
+00:17:56,240 --> 00:18:03,870
+شغالة بهذه الطريقة البقية بتكون Inactiveفحسب إذا
+
+167
+00:18:03,870 --> 00:18:08,950
+كانت هذه الـ Normal Female اللي هي الـ XX بتلاقي
+
+168
+00:18:08,950 --> 00:18:15,530
+بتشوف هيكي واحد Bar Body اللي هو شو اسمه اللي هو
+
+169
+00:18:15,530 --> 00:18:22,390
+Inactive X-Chromosome إذا عندها XXX بتكون واحد
+
+170
+00:18:22,390 --> 00:18:29,270
+Active واثنين Inactive إذا XXXX أربع نسخواحد
+
+171
+00:18:29,270 --> 00:18:34,590
+«active» وثلاثة «inactive» بالشكل هذا لأن لماذا
+
+172
+00:18:34,590 --> 00:18:42,670
+بالضبط هكذا تحصل؟ أنا ماعرف، ماعندي تفسير بشكل
+
+173
+00:18:42,670 --> 00:18:48,530
+مقنع لماذا هذه الظاهرة تحصل هكذاالنوعية الجينات
+
+174
+00:18:48,530 --> 00:18:55,430
+اللي بنحتاجها، إذا في آليات أخرى، يعني زي تبعات
+
+175
+00:18:55,430 --> 00:18:59,050
+الـ Immunoglobulins، Allelic Exclusion، إذا واحد
+
+176
+00:18:59,050 --> 00:19:04,530
+اشتغل، هو بيسكر على الثاني، ما بعرف، ماشي؟ بس هذه
+
+177
+00:19:04,530 --> 00:19:08,410
+الظاهرة هيك بتصير، يعني هي النقطة اللي بدك تاخدها،
+
+178
+00:19:08,410 --> 00:19:16,330
+ماشي؟في سؤال من أسماء تتكلم بتقول المحاضرة السابقة
+
+179
+00:19:16,330 --> 00:19:21,370
+ذكرت لدكتور أنه ممكن نميز المرأة عن الرجل عن طريق
+
+180
+00:19:21,370 --> 00:19:27,030
+الـ bar body لعدم وجودها في الرجل ولكن تم تصنيف
+
+181
+00:19:27,030 --> 00:19:33,850
+مرض Turner على أنه أنثى رغم عدم احتواء على الـ bar
+
+182
+00:19:33,850 --> 00:19:36,970
+body فكيف هذه النقطة؟ مش عارف إذا جريت السؤال صح
+
+183
+00:19:36,970 --> 00:19:41,770
+يا أسماء أو لايعني هي بتسأل أنه الـ bar body هو
+
+184
+00:19:41,770 --> 00:19:47,110
+اللي كان بيميز المرأة عن الراجل؟ لأ لأ لأ مش ما
+
+185
+00:19:47,110 --> 00:19:54,530
+قلت هيك أو مش هاي المظبوط افهم الشغل أسس التراكيب
+
+186
+00:19:54,530 --> 00:20:04,000
+الجنسية سواء الخارجيةقناة «مجرال بول» كيف الأعضاء
+
+187
+00:20:04,000 --> 00:20:12,420
+التناثلية الخصيطين المبايض بشكل استدى كذا كذا هذه
+
+188
+00:20:12,420 --> 00:20:20,600
+الظواهر وهذه الأشياء بدرجة أساسية تكون مرتبطة مع
+
+189
+00:20:20,600 --> 00:20:25,080
+وجود أو عدم وجود الـY-Chromosome دعوني أتفق على
+
+190
+00:20:25,080 --> 00:20:31,560
+ناحية هذهلما تشوفي Turner ماشي، انت بتحطه صور
+
+191
+00:20:31,560 --> 00:20:36,420
+الـTurner هسه أنا صور بعض الأشياء اللي موجودة لهذه
+
+192
+00:20:36,420 --> 00:20:42,000
+الأشياء يعني محرج شويه، ماحطيتش صورها بس طلع عليها
+
+193
+00:20:42,000 --> 00:20:51,940
+في الكتاب منظر الـTurner هي أنثى قصيرة المظاهر
+
+194
+00:20:51,940 --> 00:20:57,830
+الأنوث عليها مش peer قويةوفيه على الرقب بتحس
+
+195
+00:20:57,830 --> 00:21:04,350
+بيسموها يعني Web اللي هو يعني حوالين الرقب يلهم
+
+196
+00:21:04,350 --> 00:21:10,470
+مظهر مميز فالآن بس بالأخير يعني شكل الأعضاء
+
+197
+00:21:10,470 --> 00:21:15,370
+التناسلية بتقول هي أنفة ما بتقول عنها رجل فاهم
+
+198
+00:21:15,370 --> 00:21:21,050
+علي؟ فالآن إذا
+
+199
+00:21:21,050 --> 00:21:29,490
+افترضنا الإنسانضمن مجموعة وأظن إنه يعني هو جزء من
+
+200
+00:21:29,490 --> 00:21:33,970
+الطبيعي يعني مش يعني صحيح ممكن بعض الناس يكون عنده
+
+201
+00:21:33,970 --> 00:21:40,790
+مختلال بس بيكون نخترض إنسان طبيعي ولغرض ما زي
+
+202
+00:21:40,790 --> 00:21:48,730
+تيرنر آجي أنا بعمل الـ الـ الـ Bar Buddy مثلا راح
+
+203
+00:21:48,730 --> 00:21:53,540
+ألاقي إنه فعلا مافيش Bar Buddyهو أقرب للذكورة، بس
+
+204
+00:21:53,540 --> 00:21:57,840
+الذكورة أهم شي بميزة وجود الـY الـY مش موجود، مش
+
+205
+00:21:57,840 --> 00:22:05,400
+يعني، مدام الـY مش موجود، ماشي، راح تتحول الأليات
+
+206
+00:22:05,400 --> 00:22:10,900
+كلها باتجاه الأنثى، هيك بيكون، ماشي، فليش تيرنر
+
+207
+00:22:10,900 --> 00:22:16,500
+أنثى؟ لأنه مافيش Y، هذا باختصار، بس مش أنثى طبيعية
+
+208
+00:22:16,500 --> 00:22:24,050
+لأنه ماعنداش XX اللي هو متوقعبتكون XO ماشي وفيه
+
+209
+00:22:24,050 --> 00:22:31,210
+Super Female بتلاقي XXX مثلا وش اسمه؟ وفيه يعني
+
+210
+00:22:31,210 --> 00:22:37,690
+هدولة بشكل عام يعني واضح؟
+
+211
+00:22:37,690 --> 00:22:47,300
+آخر يعني مع النقطة اللي بدنا نحكيهااللي هي
+
+212
+00:22:47,300 --> 00:22:54,380
+Androgen Insensitivity Syndrome أو اللي هنا حاطينا
+
+213
+00:22:54,380 --> 00:23:00,120
+بالـ Female بالنسبة للـ XY فأحنا يعني أنا اللي
+
+214
+00:23:00,120 --> 00:23:04,420
+شرحته قبل شوية كل الكلام على إنه إذا الـ Y موجود
+
+215
+00:23:04,420 --> 00:23:10,960
+فالغالب راح يشتغل إنه يكون يطلع بشكل ذكر، ماشي؟
+
+216
+00:23:10,960 --> 00:23:17,980
+بالنسبة للمن يكون أحيانًاالـ Y كمان موجود بس
+
+217
+00:23:17,980 --> 00:23:22,720
+مظهريًا بتبين أنت ماشي، هذا بيسموه تفتكلر
+
+218
+00:23:22,720 --> 00:23:27,120
+-feminization syndrome أحيانًا إلها اسم زي هيته أو
+
+219
+00:23:27,120 --> 00:23:32,740
+الـ Androgen Insensitivity Syndrome الوصف لهذا
+
+220
+00:23:32,740 --> 00:23:42,140
+الإنسان، ماشي، بيكون إنه أولًا عنده خصية، ماعندهوش
+
+221
+00:23:42,140 --> 00:23:50,040
+مبايظيعني بتكون التراكيب الجنسية الداخلية ذكر
+
+222
+00:23:50,040 --> 00:23:56,340
+بيكون عنده خصية بيكون الخصية بتشتغل، بتطلع
+
+223
+00:23:56,340 --> 00:24:03,480
+الـAndrogen بس وظيفة الهرمونات الذكرية غير فاعلة
+
+224
+00:24:03,480 --> 00:24:12,820
+ففي هذا المظهر بتلاقيها مظهريًا بتبين أنثى يعني
+
+225
+00:24:12,820 --> 00:24:20,430
+الأداءالمجلة الـ bowling خارجي ماشي بيكون على شكل
+
+226
+00:24:20,430 --> 00:24:28,950
+أنثى و .. بس من جوا الـ gonads والتراكيب الداخلية
+
+227
+00:24:28,950 --> 00:24:36,930
+يعني ما عندها رحمة ما عندها مضايض بتلاقي موجود شو
+
+228
+00:24:36,930 --> 00:24:46,920
+اسمه اللي هو خصية جوا وتراكيب ثانية ومشبس التراكيب
+
+229
+00:24:46,920 --> 00:24:52,760
+الخارجي المهبل بتلاقيه موجود وهدولة ميزتهم يعني
+
+230
+00:24:52,760 --> 00:24:59,140
+حتى لو واحد يتذكر هذه الحالة بتقول إن الشعر في
+
+231
+00:24:59,140 --> 00:25:08,620
+منطقة العاني والإبط مش موجود هدولة يعني حالة خاصة
+
+232
+00:25:08,620 --> 00:25:15,330
+بيقول فيها Y-Chromosomeبس مش شغال كأنه مش موجود
+
+233
+00:25:15,330 --> 00:25:21,630
+وبشبه نظرياً الـ Female بتكون الأمور مخربطة، ماشي؟
+
+234
+00:25:21,630 --> 00:25:27,300
+فهدولة الحالة اللي بنعتبرها ثالثةبشكل عام الـ Clam
+
+235
+00:25:27,300 --> 00:25:31,780
+Filter والـ Turner اذكروهم طبعاً Super Female أو
+
+236
+00:25:31,780 --> 00:25:40,360
+XXY بيكون اللي هو XXY Clam Filter أو أكثر XXXY أو
+
+237
+00:25:40,360 --> 00:25:46,580
+غيره، ماشي وفي اللي هو الـ Androgen Insensitivity
+
+238
+00:25:46,580 --> 00:25:52,260
+Syndrome اللي هو بيكون نوعية ثالثةبيكون صح الـ Y
+
+239
+00:25:52,260 --> 00:25:56,720
+موجود بس مش شغال كأنه مش موجود وبالتالي فبتطلع
+
+240
+00:25:56,720 --> 00:25:57,720
+الأمور مقربة
+
+241
+00:26:05,730 --> 00:26:15,210
+هنا تفاصيل أكثر عن إيش يعني الـ «Climb Filter»
+
+242
+00:26:15,210 --> 00:26:19,910
+حكينا تقريباً هو أشعة واحد ألف وواحد على ستمية
+
+243
+00:26:19,910 --> 00:26:29,120
+بكون طول ماليعني هنا الـ… بيكونوا في عندهم مشاكل
+
+244
+00:26:29,120 --> 00:26:33,600
+في الخلف وما بيستطيع يعني فيه Hypogonadism
+
+245
+00:26:33,600 --> 00:26:38,420
+أزوسبيرميا، Infertility وبيكونوا في عندهم مشاكل
+
+246
+00:26:38,420 --> 00:26:46,180
+الـXYY بالنسبة للـSex Development طبيعي برضه Tall
+
+247
+00:26:46,180 --> 00:26:49,860
+Male يعني
+
+248
+00:26:49,860 --> 00:26:56,170
+هو بيحاولوا الـيعطوكم المظاهر
+
+249
+00:26:56,170 --> 00:27:02,690
+تبعيتهم وبالنسبة للـ Turner اللي هو الواحد في كل
+
+250
+00:27:02,690 --> 00:27:08,670
+أربع تلاف تقريبًا بـ Short Stature بيكون قصيرة في
+
+251
+00:27:08,670 --> 00:27:15,070
+الـ Web Neck اللي هو حكيمة على الرقبة بيكون زي
+
+252
+00:27:15,070 --> 00:27:21,620
+الغشاء هيكعلى جانب طالع Risk of Cardiac Anomalies
+
+253
+00:27:21,620 --> 00:27:30,020
+عادة الـ Mental ممكن Typically Normal بس أحياناً
+
+254
+00:27:30,020 --> 00:27:36,690
+بيكون فيه Retardation شويةأو الـ Impaired Social
+
+255
+00:27:36,690 --> 00:27:43,050
+Adjustments يعني هون الأمثلة على الأمراض الأساسية
+
+256
+00:27:43,050 --> 00:27:48,250
+تبعات الـ X-Chromosome Abnormalities أو الـ Sex
+
+257
+00:27:48,250 --> 00:27:53,050
+Chromosome Anomalies، ماشي، قاسي الأخرى؟
+
+258
+00:27:58,010 --> 00:28:07,450
+الأن تكرار تفاصيل الجينات المسؤولة عن تكوين الخصي
+
+259
+00:28:07,450 --> 00:28:12,690
+والبربخ والقناة مجرى البول بالشكل هذا عند الذكور
+
+260
+00:28:12,690 --> 00:28:26,440
+وعند الإناث وكذا، بدناشي يعنيماشي، تفاصيل التعقيد
+
+261
+00:28:26,440 --> 00:28:34,420
+الأكثر من الـ Sex chromosomes وبعدين
+
+262
+00:28:34,420 --> 00:28:38,640
+الجينات اللي على الـ Sex chromosomes وكيف تتحكم في
+
+263
+00:28:38,640 --> 00:28:43,830
+أن المظهر يكون بالشكل هذااللي راح فيه عندنا حالة
+
+264
+00:28:43,830 --> 00:28:49,130
+يعني إذا بتعرفوها «precocious pre-puberty» يعني
+
+265
+00:28:49,130 --> 00:28:55,850
+البلوغ المبكر بتلاقي أنثى أو ذكر طبعاً بالأول
+
+266
+00:28:55,850 --> 00:29:02,900
+الإنسان يعنيبيولد بطوله حجم معين بتلاقي المرحلة
+
+267
+00:29:02,900 --> 00:29:09,720
+الطفولة بتلاقي الإنسان ماعلوش مظاهر جنسية نموه
+
+268
+00:29:09,720 --> 00:29:14,620
+بشكل عام بعد أول سنة بيصير يبطأ يبطأ لحد ما تيجي
+
+269
+00:29:14,620 --> 00:29:21,180
+فترة الغلوغ وبعدين بتلاقي نموه بشد بشكل كبير فاللي
+
+270
+00:29:21,180 --> 00:29:30,010
+عنده غلوغ مبكر ماشي بتلاقي أولاًأولها بيتلاقي فترة
+
+271
+00:29:30,010 --> 00:29:34,950
+وارتفعة بشكل كبير وصار النمو عنده في الطول وفي
+
+272
+00:29:34,950 --> 00:29:40,810
+المظاهر كبير بس بعدين في المحصلة النهائية راح تكون
+
+273
+00:29:40,810 --> 00:29:46,150
+إنه لأ راح يطلع طوله أقصر من غيره اللي بتأخره بس
+
+274
+00:29:46,150 --> 00:29:51,170
+بيظلوا مدة أكبر وهو ينمو فهذه المظاهر بتأثر على
+
+275
+00:29:51,170 --> 00:29:55,860
+أشياء كثيرة وبالأخير يعني كمان نحكي إنهغير هذه
+
+276
+00:29:55,860 --> 00:29:59,620
+الأمور كعوامل
+
+277
+00:29:59,620 --> 00:30:06,420
+تأثير على نمو وتطور الإنسان الجنسيكما تتدخل فيها
+
+278
+00:30:06,420 --> 00:30:13,620
+الجوانب الإجتماعي والمجتمعية وتعامل المجتمع معاه
+
+279
+00:30:13,620 --> 00:30:23,500
+وتقبل الناس إليه كشخص واضح حتى
+
+280
+00:30:23,500 --> 00:30:30,660
+في الشارع يوجد مباحث معينة تقولالخمسة يعني شخص
+
+281
+00:30:30,660 --> 00:30:36,540
+أعضاءه مش مبينة هي ذكر ولا أنثى، هذه أه و الله
+
+282
+00:30:36,540 --> 00:30:41,420
+بتحدث و أحياناً في ناس هيكي و كيف ده بتتعامل معاه،
+
+283
+00:30:41,420 --> 00:30:47,860
+فيه له جانب في الطبلأطباء يعني الغدد الصماء
+
+284
+00:30:47,860 --> 00:30:52,600
+بتدخلوا فيها أطباء المسالك البولية أو أطباء
+
+285
+00:30:52,600 --> 00:31:01,300
+النسائية بتلاقي يعني فيه تخصصات في الطببيدرسوا
+
+286
+00:31:01,300 --> 00:31:07,720
+يعني كيفية يعني فيه اللي بيسموه true hermaphrodite
+
+287
+00:31:07,720 --> 00:31:13,020
+true hermaphrodite اللي هو يعني الخنثة الحقيقية
+
+288
+00:31:13,020 --> 00:31:21,480
+بتلاقي شخص عنده خصية و مثلا قضيب و ذكر و يحيط
+
+289
+00:31:21,480 --> 00:31:26,640
+فهناك رحم حقيقي الداخل في حيث أنه بتصير دورة شهرية
+
+290
+00:31:26,640 --> 00:31:32,320
+و بنزل الدمبتلاقي أحيانًا يعني أشخاص عندهم
+
+291
+00:31:32,320 --> 00:31:40,040
+إبتلاءات وأمراض بتكون إنه التطور الجنسي غير كامل
+
+292
+00:31:40,040 --> 00:31:45,920
+غير واضح، غير سليم، يعني هناك إشكالية فيها فهذه
+
+293
+00:31:45,920 --> 00:31:49,180
+جوانب
+
+294
+00:31:49,180 --> 00:31:57,310
+يعني خلّيني على الأمثلة الكبيرةيعني اللي حطناها
+
+295
+00:31:57,310 --> 00:32:04,290
+قبل شوية وخلّينا الأمثل الكبير ونفهم تداخلها ما
+
+296
+00:32:04,290 --> 00:32:11,510
+بين أولاً كروموزومات لجينات لهرمونات لتراكيب بعد
+
+297
+00:32:11,510 --> 00:32:20,430
+ذلك تدخل في قضية يعني كيف المجتمع يتعامل مع هذا
+
+298
+00:32:20,430 --> 00:32:27,990
+الموضوعيعني إذا التراكيب البولية الخارجية مش واضحة
+
+299
+00:32:27,990 --> 00:32:33,810
+أحيانًا بتضطر على حتى عمر صغير أحيانًا الجراح
+
+300
+00:32:33,810 --> 00:32:38,410
+بتضطر يدخل ويعدل ويظبط وكذا إذا مثلًا فيه
+
+301
+00:32:38,410 --> 00:32:45,500
+hypospadias بتكون فتحة قناة Magical Ballعند الولد
+
+302
+00:32:45,500 --> 00:32:53,880
+يعني فيها مشكلة و بتلاقي الجراح مثلا بدخل بظبطها ب
+
+303
+00:32:53,880 --> 00:32:58,420
+.. ب .. ب .. في عمليات طبعاً تسمعوا عنها للناس
+
+304
+00:32:58,420 --> 00:33:02,960
+أحياناً نتيجة هذه المشكلة بيصير عنده مرض نفسي ومش
+
+305
+00:33:02,960 --> 00:33:07,100
+عارف حاله ولد ولا بنت، ذكر ولا أمثة ويصير يطلب
+
+306
+00:33:07,100 --> 00:33:16,800
+يغيروا جنسه يعني هذه أشياءيعني صحيح المجتمعات اللي
+
+307
+00:33:16,800 --> 00:33:23,200
+أدخل فيها أحيانًا ولكن أيضًا الـ يعني في أحيانًا
+
+308
+00:33:23,200 --> 00:33:31,700
+بشر عندهم مرض وبكون ما بين يعني هرموناته،
+
+309
+00:33:31,700 --> 00:33:38,760
+جيناته، روموزوماته بتكون الأمور مختلفة زائد تأثير
+
+310
+00:33:38,760 --> 00:33:43,390
+المجتمع يعني كيف الأهلبيربوا الولد أو بيربوا البنت
+
+311
+00:33:43,390 --> 00:33:47,770
+يعني البنت بيجيبولها لعاب بيلبسوها بشكل حلو
+
+312
+00:33:47,770 --> 00:33:53,070
+بيهتموا فيها بطريقة مختلفة اللعبة اللي بتكون وكذا
+
+313
+00:33:53,070 --> 00:33:57,970
+أحياناً هي بتأثر نفسية على حتى تطور الإنسان بعد
+
+314
+00:33:57,970 --> 00:34:06,830
+ذلك فلحد هنا هاي اللي هي المواضيع اللي يعني
+
+315
+00:34:09,650 --> 00:34:14,250
+المواضيع اللي بنعتبر كانت
+
+316
+00:34:14,250 --> 00:34:18,430
+في قضية الـ
+
+317
+00:34:18,430 --> 00:34:23,510
+«Closed Zone»؟ لأ، خلّيني أشوف، أسسا ندخل على
+
+318
+00:34:23,510 --> 00:34:31,990
+المحاضرة التالية في أسئلة؟ في حد في عنده صعوبة في
+
+319
+00:34:31,990 --> 00:34:35,330
+شغله؟ «Genetics»؟
+
+320
+00:34:38,950 --> 00:34:54,170
+عشان أفتح المحاضرة اللي بعدها هسا
+
+321
+00:34:54,170 --> 00:35:04,130
+المجموعة اللي بعدها إحنا خلصنا أكبر أو المجموعة
+
+322
+00:35:04,130 --> 00:35:11,360
+اللي مميز إلها كثرتالمظاهر المرضية بسبب أنه عدد
+
+323
+00:35:11,360 --> 00:35:18,260
+الجينات المشتركة في قضية الاختلال نتيجة أن
+
+324
+00:35:18,260 --> 00:35:22,600
+الكروموزوم كله فيه إشي غلط فراح ينتج عنه عادة
+
+325
+00:35:22,600 --> 00:35:30,600
+أمراض شديدة وبتكون أحياناً كثيرة يعني غير not
+
+326
+00:35:30,600 --> 00:35:35,180
+compatible even with life يعني أشياء زي ما حكينا
+
+327
+00:35:35,600 --> 00:35:43,200
+مربوط أكثر بقضية الـ Abortions، حلّات الإجهاد
+
+328
+00:35:43,200 --> 00:35:48,860
+وبتكون نتيجة إنه حدد كبير من الجينات بتكون مصابة
+
+329
+00:35:48,860 --> 00:35:53,930
+أو مختلة، سواء بالزيادة، بالنقصانبالتغيير،
+
+330
+00:35:53,930 --> 00:35:58,550
+بالتخريب، بالـ «كدا»، ففيها أشياء كثيرة في سؤال من
+
+331
+00:35:58,550 --> 00:36:04,510
+«مورا سماح»، قال يعني دكتور مش مطلوب منه نعرف
+
+332
+00:36:04,510 --> 00:36:07,410
+الأمراض الناتجة عن خلل بالجينات، بس نقتصر على
+
+333
+00:36:07,410 --> 00:36:13,990
+الأمراض الرئيسية؟ لأ، أنا يعني مش مطلوب ومطلوب
+
+334
+00:36:13,990 --> 00:36:21,760
+يعني لو واحد قرأهوحاول يفهم ونجح، ممتاز، كويس يصير
+
+335
+00:36:21,760 --> 00:36:26,660
+عنده معلومات أكثر بس أنا بتكلم أنه تفاصيل الأمور
+
+336
+00:36:26,660 --> 00:36:31,660
+يعني على إيش الجينات الموجودة على الـ Y-Chromosome
+
+337
+00:36:31,660 --> 00:36:38,340
+وشو الأليات تتخلي هذا الرجل يصير شكله رجلأنه اللي
+
+338
+00:36:38,340 --> 00:36:43,320
+بيأثر على الشعر، أنه اللي بيأثر شعر اللحن، يعني
+
+339
+00:36:43,320 --> 00:36:49,540
+ليش صوته بقى جش وحجم الحنجرة أكبر؟ ليش الـSperms
+
+340
+00:36:49,540 --> 00:36:53,180
+هم اللي بيطلعوا؟ كيف بيسيطر؟ يعني تفاصيل الأمور،
+
+341
+00:36:53,180 --> 00:37:01,560
+خلاص، اتركوني، ماشي، ما تقعدي تدقيقي وكذا وهكذا،
+
+342
+00:37:01,560 --> 00:37:10,470
+ماشي، ما تشددوشفيشدد عليكم، فاتركوا الموضوع أهم
+
+343
+00:37:10,470 --> 00:37:15,490
+شيء المبادئ الـ Barbary يمثل Inactive X-Chromosome
+
+344
+00:37:15,490 --> 00:37:20,150
+فشو ما كان فيه X-Chromosomes Inactive راح يبين
+
+345
+00:37:20,150 --> 00:37:26,750
+عددهم بشكل Barbary الأصل في مظهر الرجل يعني الـ
+
+346
+00:37:26,750 --> 00:37:31,930
+Default لو مافيش إشي تطلع أنثىيعني الإعداد
+
+347
+00:37:31,930 --> 00:37:36,390
+الإفتراضي لـ System البشر ربنا حطنا إنه تطلع
+
+348
+00:37:36,390 --> 00:37:43,030
+بالأول أنثى، ماشي؟ وجود الـ Y هو اللي يبينه على
+
+349
+00:37:43,030 --> 00:37:47,610
+شكل الرجل فأهمية الـ Y، هذه ناحية ثانية الشغل
+
+350
+00:37:47,610 --> 00:37:52,550
+الثالث إنه صح لو الـ Y موجود بس برضه مش ضروري إنه
+
+351
+00:37:52,550 --> 00:37:58,650
+يطلع ذكر ممكن يكون Y بس يكون شكلها أنثى ويكون أمور
+
+352
+00:37:58,650 --> 00:38:02,760
+مخربطة من جوهرناماشي خلّينا نحطها بهذا الشكل
+
+353
+00:38:02,760 --> 00:38:08,200
+الجداول اللي حطيتها على أو الصور اللي حطوها
+
+354
+00:38:08,200 --> 00:38:16,200
+بالنسبة الشكل climb filter تيرنار كيف بتكون هاي أه
+
+355
+00:38:16,200 --> 00:38:21,820
+هي حكيتها وذكرناها تفاصيل أكثر من هيك exact
+
+356
+00:38:21,820 --> 00:38:25,620
+details مابدوش أه في إشي تاني
+
+357
+00:38:28,670 --> 00:38:33,030
+تمام، يا دكتور، لا شيء يعني لحد اللي أنا نفسي طيب
+
+358
+00:38:33,030 --> 00:38:36,270
+الآن
+
+359
+00:38:36,270 --> 00:38:42,770
+بدنا ندخل على اللي بيسموها الوراثة المنديلية اللي
+
+360
+00:38:42,770 --> 00:38:50,630
+هم الأمراض والحالات والمشاكل اللي بيكون single
+
+361
+00:38:50,630 --> 00:39:02,780
+gene هو المسؤول عنها وهدولة يعني صحيحيعني هتلاقي
+
+362
+00:39:02,780 --> 00:39:07,620
+أعدادهم بالألاف يعني الـ Online Mendelian
+
+363
+00:39:07,620 --> 00:39:15,820
+Inheritance Website هتلاقي حوالي يعني بعشرات
+
+364
+00:39:15,820 --> 00:39:22,260
+الألاف من الأمراض وهناك مراجع ويتم تحديثها دائما
+
+365
+00:39:22,260 --> 00:39:35,950
+بقضايا يعنيبقضايا جديدة أنا بس بدي أحط صورة وديتها
+
+366
+00:39:35,950 --> 00:39:43,690
+للدكتور أحمد الأسبوع اللي فات فخليني
+
+367
+00:39:43,690 --> 00:39:48,830
+بس أضيفها هاي
+
+368
+00:39:48,830 --> 00:39:49,730
+هنا
+
+369
+00:39:53,470 --> 00:40:04,470
+خلّيني أشوف إذا بتبين هنا، لأ مش هذا، ما هو اسمه؟
+
+370
+00:40:04,470 --> 00:40:09,650
+save image على
+
+371
+00:40:09,650 --> 00:40:11,430
+الـ desktop، ماشي
+
+372
+00:40:21,420 --> 00:40:25,340
+دكتور انت ما تنسخها داخل مربع النص انسخها على
+
+373
+00:40:25,340 --> 00:40:28,400
+الشريحة نفسها يعني خارج الشريحة يعني انقر خارج
+
+374
+00:40:28,400 --> 00:40:34,660
+الشريحة اللصحة طيب خليني أشوف دقيقة، دقيقة، دقيقة،
+
+375
+00:40:34,660 --> 00:40:38,340
+دقيقة، دقيقة، دقيقة،
+
+376
+00:40:38,340 --> 00:40:41,340
+دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة،
+
+377
+00:40:41,340 --> 00:40:43,220
+دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة،
+
+378
+00:40:43,220 --> 00:40:46,380
+دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة،
+
+379
+00:40:46,380 --> 00:40:47,800
+دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة،
+
+380
+00:40:47,800 --> 00:40:50,410
+دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دهذه صورة من
+
+381
+00:40:50,410 --> 00:41:01,110
+عندي يعني عبارة عن عائلة اللي بتحكيها عبارة
+
+382
+00:41:01,110 --> 00:41:06,990
+عن أب و أم هما الأخوة من سوريا في قرابة بين الأب
+
+383
+00:41:06,990 --> 00:41:16,450
+والأم عندهم تسع أبناء و بنات التسعة خمسة منهمبطلع
+
+384
+00:41:16,450 --> 00:41:23,710
+على إيديهم ورجليهم وعلى راسهم تدرونات بهذا الشكل،
+
+385
+00:41:23,710 --> 00:41:34,350
+ماشي؟ هذه الظاهرة يعني أول شيء طبعاً لما واحد
+
+386
+00:41:34,350 --> 00:41:40,610
+يتعرف على عائلة بهذا الشكل، ماشي؟النقطة الأساسية
+
+387
+00:41:40,610 --> 00:41:47,910
+أولًا يعني لازم يحاول يروح يدور في المراجع العلمية
+
+388
+00:41:47,910 --> 00:41:53,370
+ويحاول يشوف إذا فيه إشي حد ذكر حالة قريبة حالة
+
+389
+00:41:53,370 --> 00:42:01,430
+يعني مشابهة، حالة قريبة منها فأقرب شيء لهذا المنظر
+
+390
+00:42:01,430 --> 00:42:04,670
+عبارة عن حالة تسمى «Infantile Digital
+
+391
+00:42:04,670 --> 00:42:13,740
+Fibromatosis»يعني في الأطفال على
+
+392
+00:42:13,740 --> 00:42:23,880
+الأصابع يكون هناك تليفات فيعني أنا حتى الأقرب شيء
+
+393
+00:42:23,880 --> 00:42:31,420
+بستطيع أقول إنه هذا قريب من شيء عند إنسان كانت إنه
+
+394
+00:42:31,420 --> 00:42:34,600
+هذا أقرب حالي لما حطيت الصورة تبع الـInfantile
+
+395
+00:42:34,600 --> 00:42:40,910
+Digital Fibromasosisفهي طبعًا بتكون على موليد جدد
+
+396
+00:42:40,910 --> 00:42:45,090
+هاي الظاهرة عند هاي العائلة بهذا الأطفال اللي
+
+397
+00:42:45,090 --> 00:42:48,090
+عندهم الأبناء والبنات المصابين على عمر العشرة
+
+398
+00:42:48,090 --> 00:42:53,510
+وخمستاشر سنة لإنها تبدأ تظهر وبيظل لحد عمره كبير
+
+399
+00:42:53,510 --> 00:42:57,070
+ويطلع أشياء جديدة في التلاتينات والأربعينات يعني
+
+400
+00:42:57,070 --> 00:43:02,730
+الأباء خمسينات أو ستينات الأب والأموالأبناء فيه
+
+401
+00:43:02,730 --> 00:43:07,650
+إشي تلاتين وخمس وتلاتين واشياء لحوالي عشر سنوات
+
+402
+00:43:07,650 --> 00:43:14,090
+بعضهم مصابين فلما تلاقي الواحد موضوع زي هيك بصير
+
+403
+00:43:14,090 --> 00:43:21,050
+يعني الإشكالية عندنا أول شيء دكوره إناث مصابين في
+
+404
+00:43:21,050 --> 00:43:31,300
+العائلة وعدد كبير مشترك فشكنا إنه يكونيعني خلال
+
+405
+00:43:31,300 --> 00:43:37,800
+اللي فيه قرابة بين الأبوين ممكن تكون هي autosomal
+
+406
+00:43:37,800 --> 00:43:42,980
+وليس الـ X-linked process لو X-linked كان الذكور
+
+407
+00:43:42,980 --> 00:43:47,080
+مصابين الإناف غير مصابات بس بما أنه فيه ذكور وإناف
+
+408
+00:43:47,080 --> 00:43:53,840
+معناته مشكلة بهذا الشكلالإشكالية اللي عنا وجهناها
+
+409
+00:43:53,840 --> 00:44:02,840
+لما حاولنا ندرس ويعني to report this case كانت إنه
+
+410
+00:44:02,840 --> 00:44:12,600
+ما فيش أي في العالم كله شيء سابق عن يعني قضية
+
+411
+00:44:12,600 --> 00:44:21,330
+المسبب لهذا المرض فعشان هيك يعني الـ Karyotypeأظن
+
+412
+00:44:21,330 --> 00:44:25,670
+إنه مرح، الاحتمال إنه يعني غير الأصابع وجود
+
+413
+00:44:25,670 --> 00:44:30,310
+المشكلة عليهم بهذا الشكل في الدماغ، في القلب، في
+
+414
+00:44:30,310 --> 00:44:34,790
+الأعضاء الداخلية العائلة الطبيعية، ماكانش عندهم
+
+415
+00:44:34,790 --> 00:44:39,330
+مشاكل يعني فبالنسبة إلينا يعني الاحتمال إنه هاي
+
+416
+00:44:39,330 --> 00:44:44,290
+Single Gene Disorder وبالتالي بنقول عنها
+
+417
+00:44:44,290 --> 00:44:50,600
+«Mendelian» وحاليًا أحنا غير قادرين على إنهنحدد
+
+418
+00:44:50,600 --> 00:44:54,860
+أنهو الجين فالأسلم
+
+419
+00:44:54,860 --> 00:44:59,060
+والأحسن هو أن الواحد يعمل اللي بيسموه «whole
+
+420
+00:44:59,060 --> 00:45:03,180
+genome sequencing» أني قاعد أقرأ كل الـ «DNA» تبع
+
+421
+00:45:03,180 --> 00:45:10,400
+مصاب أو مصابين وسليمان اثنين ومع الأب والأم لو عند
+
+422
+00:45:10,400 --> 00:45:18,090
+العيلة هذه بالكامل ودرستها كلهابصير بقدر أنا أحدد
+
+423
+00:45:18,090 --> 00:45:25,110
+أكثر أنه أتوقع الجين المسؤول عن هذا الأمر يعني هذه
+
+424
+00:45:25,110 --> 00:45:31,270
+تجربة خلال الفترة القريبة اللي السابقة لحالي وإنه
+
+425
+00:45:31,270 --> 00:45:36,770
+هيك العلم بتقدم إنه الواحد بيشوف مظهر معين بيشوف
+
+426
+00:45:36,770 --> 00:45:42,050
+حالة معينة بيشوف ظاهرة معينة بيحاول بعدين يفكر
+
+427
+00:45:42,050 --> 00:45:48,220
+فيها ويشوف شو أسبابهاالفكرة الثانية هي قضية إنه
+
+428
+00:45:48,220 --> 00:45:53,400
+الواحد لازم يفرق بين ما يسمى الـ «فينوتيب» والـ
+
+429
+00:45:53,400 --> 00:45:59,600
+«جينوتيب» عندما نتكلم عن تركيب الجينات والوراثة
+
+430
+00:45:59,600 --> 00:46:05,740
+لإنسان معين ماشي، ندرس هذا المستوى بيكون إحنا
+
+431
+00:46:05,740 --> 00:46:12,700
+بنتكلم عن مستوى الجيناتطبعًا من الـ … يعني كنت في
+
+432
+00:46:12,700 --> 00:46:17,960
+المحاضرة الأولى ذكرت جاروب مندل «جريجوري مندل»
+
+433
+00:46:17,960 --> 00:46:24,460
+بالـ 1840 على البازلاء وإشي كان طويل، إشي قصير،
+
+434
+00:46:24,460 --> 00:46:31,800
+إشي أخضر، إشي أصفر، إشي الوردة تبعته طرفية على
+
+435
+00:46:31,800 --> 00:46:38,660
+النهائي من فوق أو على جانب، جانبية ف… وحط قضية إنه
+
+436
+00:46:38,890 --> 00:46:45,990
+هناك مظاهر أو صفات وراثية سائدة وهناك صفات متنحية
+
+437
+00:46:45,990 --> 00:46:55,990
+فلمّا مبدأ سائد ومتنحي نتكلم هنا عن الـ Single
+
+438
+00:46:55,990 --> 00:47:02,630
+gene disorders الأشياء اللي بتكون مسؤول عنها جين
+
+439
+00:47:02,630 --> 00:47:06,950
+واحد حفظ
+
+440
+00:47:06,950 --> 00:47:13,070
+مندلإنه ما
+
+441
+00:47:13,070 --> 00:47:16,870
+قام من دراسته من كل الصفات حوالي ستة أو ثمانية
+
+442
+00:47:16,870 --> 00:47:23,690
+كانت كلها على كرموزومات مختلفة فنتج عن ذلك إنه
+
+443
+00:47:23,690 --> 00:47:33,270
+انفصال الصفاتين يعني مثلًا البازلة الصفرة الـ الـ
+
+444
+00:47:33,270 --> 00:47:42,590
+الـ المجعلقةشكل الحب تبعتها مجعلكة ولا smooth يعني
+
+445
+00:47:42,590 --> 00:47:48,950
+مش مش مجعلكة يعني فكل صفة من اللي كان بدرسها مندل
+
+446
+00:47:48,950 --> 00:47:53,890
+كانت على كرموزوم مختلف وبالتالي أعطتنا شكل معين من
+
+447
+00:47:53,890 --> 00:47:59,230
+كان استطاع أنه ينتبه لمبادع في الوراثة مهم كثير بس
+
+448
+00:47:59,230 --> 00:48:04,930
+لأنه كمان أن الحق خدمهإن السفات اللي درسها كانت
+
+449
+00:48:04,930 --> 00:48:12,210
+منفصلة عن بعض أما لو تخيلنا إنه سفتين قريبات على
+
+450
+00:48:12,210 --> 00:48:17,370
+بعض في نفس الـ Chromosome إذا مثلا إنسان عنده شيء
+
+451
+00:48:17,370 --> 00:48:23,190
+سائد لحدهما مثلا متنحي مع الآخر راح تصير عملية
+
+452
+00:48:23,190 --> 00:48:26,810
+الوراثة وعملية انتقال للسفات الوراثية راح تكون
+
+453
+00:48:26,810 --> 00:48:33,270
+خربطة أو مش بالسهولة اللي بنتكلم عنهامن الأشياء
+
+454
+00:48:33,270 --> 00:48:36,690
+اللي سويتها على طول للعائلة السورية اللي أنا
+
+455
+00:48:36,690 --> 00:48:45,070
+سويتها قضية إنه يرسم الواحد شجرة العائلة شجرة
+
+456
+00:48:45,070 --> 00:48:54,210
+العائلة مجرد حتى يعني، يعني يقترب للطبيب أو الباحث
+
+457
+00:48:54,210 --> 00:49:00,400
+من احتمالية إن يكون هناك مرض وراثيوممكن الواحد
+
+458
+00:49:00,400 --> 00:49:05,640
+يشترك مع العالم كله أنه يعني بعدين يلاقي وين الجين
+
+459
+00:49:05,640 --> 00:49:09,720
+المسؤول عن هذا الأمر فيه هناك عدد كبير من الجينات
+
+460
+00:49:09,720 --> 00:49:14,100
+نحن لا نعلم شو وظيفتها بالضبط، ليش ربنا حطها فينا،
+
+461
+00:49:14,100 --> 00:49:19,360
+وكيف بتشتغل، كيو بتعمل، لسه فيه مجاهيل كثيرة،
+
+462
+00:49:19,360 --> 00:49:25,240
+وبدالواحد دايما يشترك أنه يطور الموضوع، فأهم شيء
+
+463
+00:49:25,240 --> 00:49:32,500
+أنهبالأول، بأول ما يشوف الحالة يرسم شجرة العائلة
+
+464
+00:49:32,500 --> 00:49:38,220
+يرسم اللي بيسموه الـ Pedigree اللي هو الشجرة
+
+465
+00:49:38,220 --> 00:49:46,320
+العائلة للإصابة وللعائل المصابة وبالتالي يعني يجمع
+
+466
+00:49:46,320 --> 00:49:57,540
+تفاصيل في شكل يعني بسيط ويعنيجدول صغير حجمه صغير
+
+467
+00:49:57,540 --> 00:50:05,120
+بس يحط فيه معلومات كبيرة جداً جداً فالآن الـ
+
+468
+00:50:05,120 --> 00:50:10,440
+Pedigree بتبدأ إن الواحد لازم يميز الرموز الموجودة
+
+469
+00:50:10,440 --> 00:50:19,060
+لما نحط مربع فالمقصود فيه Male هو ذكر المستديرة
+
+470
+00:50:19,060 --> 00:50:27,340
+Femaleإذا حطه معين فإنه يكون sex unspecified يعني
+
+471
+00:50:27,340 --> 00:50:34,720
+مثلا إجهاد مبكر وكان مش مبين إن هذا ذكر ولا أنثى
+
+472
+00:50:34,720 --> 00:50:42,630
+والله جدة إمي كان عندها سبع أبناء وبناتطب قداش
+
+473
+00:50:42,630 --> 00:50:47,030
+الذكور؟ قداش الإنث؟ حد عنده تفصيل؟ لأ والله ما حد
+
+474
+00:50:47,030 --> 00:50:51,370
+عنده تفصيل إذا ماعنديش تفصيل بحطه بشكل يعني ده بقى
+
+475
+00:50:51,370 --> 00:50:57,090
+كنت لا أعلم إذا كان بشكل أكيد ذكر ولا أنثى بحط
+
+476
+00:50:57,090 --> 00:51:06,330
+الواحد هذا الشكل في جيل معين ماشيإذا بحط أرقام
+
+477
+00:51:06,330 --> 00:51:13,650
+ماشي بهذا
+
+478
+00:51:13,650 --> 00:51:18,830
+الشكل هنا number of children of six indicated يعني
+
+479
+00:51:18,830 --> 00:51:23,330
+زي ما حكينا هنا مثلا قبل شوية واحد يقول جدة أخال
+
+480
+00:51:23,330 --> 00:51:29,690
+أبوي كان عندها خمسة تلاتة ذكور واثنين اناث بهذا
+
+481
+00:51:29,690 --> 00:51:34,170
+الشكلفإذا حطوا الرقم جوا على العكس هنا واحد،
+
+482
+00:51:34,170 --> 00:51:39,390
+اثنين، ثلاثة فهنا الشخص الأول، الشخص الثاني، الشخص
+
+483
+00:51:39,390 --> 00:51:43,970
+الثالث الأول ولد، ثاني بنت وبعدين بنت، بهذا
+
+484
+00:51:43,970 --> 00:51:47,990
+الترتيب هنا number of children of six indicated
+
+485
+00:51:47,990 --> 00:51:54,410
+يعني المجموع الأب والأم هؤلاء مثلًا جابوا خمسة
+
+486
+00:51:54,410 --> 00:52:00,860
+ثلاث ولاد وبنتين، هكذا لما نحط اللون الأزرقماشي
+
+487
+00:52:00,860 --> 00:52:05,900
+فبمعناته affected مصاب segments filled for
+
+488
+00:52:05,900 --> 00:52:12,220
+different components of the phenotype يعني أنا كنت
+
+489
+00:52:12,220 --> 00:52:19,460
+بعرف مثلا أنثى حامل بهذا الشكل إنسان أنا درسته
+
+490
+00:52:19,460 --> 00:52:25,060
+يعني مثلا عنده الـ gene اللي فلاني أنا عارف مثلا
+
+491
+00:52:25,060 --> 00:52:30,520
+واحد عنده blood group إيههو الممكن يكون AA ممكن
+
+492
+00:52:30,520 --> 00:52:37,080
+يكون AO فإذا أنا عارف أنه مثلا AO بحطه أنه نص A
+
+493
+00:52:37,080 --> 00:52:42,960
+ونص O مثلا يعني ده كنت بعرف Non-penetrant carrier
+
+494
+00:52:42,960 --> 00:52:50,880
+may manifest disease يعني هو أنا اللي أحياناً نحكي
+
+495
+00:52:50,880 --> 00:52:54,440
+عن بعض الـ يعني بنحب أنه نظن أنه
+
+496
+00:52:57,770 --> 00:53:02,370
+الجينات والماد الوراثية والصفات الوراثية بنفكر
+
+497
+00:53:02,370 --> 00:53:05,090
+الأليل الـ dominant و الـ recessive الـ dominant
+
+498
+00:53:05,090 --> 00:53:10,070
+يعني بظهر و الـ recessive يعني متنحي و بتخبأ،
+
+499
+00:53:10,070 --> 00:53:15,530
+ببينش بس الدنيا مش أبيض و أسود مش فقط يا إما مصاب
+
+500
+00:53:15,530 --> 00:53:22,810
+يا إما غير مصاب أو سليم أحياناًفي درجة ظهور الحالة
+
+501
+00:53:22,810 --> 00:53:29,350
+الوراثية تتأثر بأشياء ثانية، يعني مثلًا الصلاق جزء
+
+502
+00:53:29,350 --> 00:53:36,430
+منه فيه جين مسؤول عن الصلاق وبيأثر إذا الأنثى
+
+503
+00:53:36,430 --> 00:53:42,390
+عندها أثنين منه أه بتبين يعني فيه بيبين صلاق أكثر
+
+504
+00:53:42,390 --> 00:53:49,360
+على رأسها بشكل واضحبينما في الأنثى لازم اثنين يكون
+
+505
+00:53:49,360 --> 00:53:54,340
+الجينات المسببة للصلاة بينما عند الرجال واحد بس
+
+506
+00:53:54,340 --> 00:53:58,380
+بيكفي، بيكون dominant وبتلاقي، بيبين صلاة أكثر من
+
+507
+00:53:58,380 --> 00:54:03,080
+كثير هي قضية اللي بيسموها الـ Penetration of the
+
+508
+00:54:03,080 --> 00:54:08,880
+Character يعني درجة قدرتها على الظهورObligate
+
+509
+00:54:08,880 --> 00:54:12,460
+carrier will not manifest disease يعني ليه الحامل
+
+510
+00:54:12,460 --> 00:54:18,660
+للمرضأحيانًا، يعني إحنا بنكون متأكدين إنه ظهر عند
+
+511
+00:54:18,660 --> 00:54:26,260
+إنسان مرض وكان نتيجة إنه موجود عند أبوه أو أمه، بس
+
+512
+00:54:26,260 --> 00:54:33,000
+كان الواحد منهم مش مصعب بس يعني إذا ماكنتش طفرة في
+
+513
+00:54:33,000 --> 00:54:37,680
+نفس الشخص فلازم تكون في والده أو والدته، وبالتالي
+
+514
+00:54:37,680 --> 00:54:45,610
+نرسمها بهذا الشكلإذا الشخص اللي بنتكلم عنه «موت»
+
+515
+00:54:45,610 --> 00:54:51,370
+يعني متوفى بنحط عليه خط بهذا الشكل Spontaneous
+
+516
+00:54:51,370 --> 00:55:00,270
+abortion يعني قضية إجهاد ذاتي بكون سواء مصاب أو
+
+517
+00:55:00,270 --> 00:55:07,310
+غير مصاب طبعاً هو أنا مبكر فبالتالي يعني في الأشهر
+
+518
+00:55:07,310 --> 00:55:12,530
+الأولى من الحمليمكن ما يبين ذكر ولا أنثى، ماشي،
+
+519
+00:55:12,530 --> 00:55:17,070
+بنرسمها بهذا الشكل دكتور، في سؤال من كريم، بيسأل
+
+520
+00:55:17,070 --> 00:55:23,850
+شو في أمثلة على الـobligate career؟ لأ، أنت لما
+
+521
+00:55:23,850 --> 00:55:34,190
+تتكلم عن حالة مثلا، نفترض ناخد مرض Huntington's
+
+522
+00:55:34,190 --> 00:55:41,800
+Chorea، مثلاإبارة عن مرض «Autosomal Dominant» فهو
+
+523
+00:55:41,800 --> 00:55:45,920
+سائد بتلاقي
+
+524
+00:55:45,920 --> 00:55:49,800
+الانسان
+
+525
+00:55:49,800 --> 00:55:56,720
+أنت شفته مرض يعني يعني
+
+526
+00:55:56,720 --> 00:56:01,340
+لما بدك تاخذه لما تشوف إنسان مصاب فيه أحيانًا ممكن
+
+527
+00:56:01,340 --> 00:56:06,850
+يكون أنههي طفرة اللي سببت المرض نشأت في هذا الشخص
+
+528
+00:56:06,850 --> 00:56:12,330
+وهو هينقلها لأولاده وبناته، ماشي؟ بس بيظل في
+
+529
+00:56:12,330 --> 00:56:18,350
+أحيانًا احتمالية إنه كان موجود في أبوه أو أمه
+
+530
+00:56:18,350 --> 00:56:23,410
+وكانت Carrier ولازم يكون Carrier يعني إذا بتاخد
+
+531
+00:56:23,410 --> 00:56:27,890
+مثلًا في الـ X-Chromosomes مثلًا الـG6PD
+
+532
+00:56:27,890 --> 00:56:34,660
+Deficiency جزء منه X-linked recessiveفالأم الأنثى
+
+533
+00:56:34,660 --> 00:56:40,100
+هي الحامل لازم بشكل إجباري تكون هي الحامل حتى
+
+534
+00:56:40,100 --> 00:56:45,860
+تعطيه يعني إذا واحد في مرض هو أخواله اللي هو الـ X
+
+535
+00:56:45,860 --> 00:56:53,320
+-linked chromosomes بتلاقي معناته الأم الأنثى كانت
+
+536
+00:56:53,320 --> 00:56:57,340
+هي ما بنقول عنها مصابة بس لازم تكون حامل لأنه غير
+
+537
+00:56:57,340 --> 00:57:02,420
+هيك ما كان انتقل للطفل هذافاهم عليك كيف؟ فيعني هي
+
+538
+00:57:02,420 --> 00:57:09,440
+الفكرة أن أنا بس الآن بدي أخذكم خلال الرموز هذه
+
+539
+00:57:09,440 --> 00:57:13,460
+حتى لما تشوفوها بعدين تفهموا شو معناها يعني أنا
+
+540
+00:57:13,460 --> 00:57:17,680
+هذا الآن بحاول أزويه، ماشي؟ تفاصيل الأمور، راح
+
+541
+00:57:17,680 --> 00:57:21,920
+ناخد أمثل كثيرة ونتكلم عنها، يصير الواحد يكون
+
+542
+00:57:21,920 --> 00:57:27,200
+مرتاحة ويحكي عن حاجة معينة، ماشي؟
+
+543
+00:57:29,990 --> 00:57:35,770
+الخط الثاني من فوق Marriage أو Union يعني زواج لما
+
+544
+00:57:35,770 --> 00:57:40,810
+نحط ذكر وأنثى بهذا الشكل إذا حطيت خطين بالنص هنا
+
+545
+00:57:40,810 --> 00:57:45,790
+يعني مطلقين إذا حطيت Double Bond يعني
+
+546
+00:57:45,790 --> 00:57:53,110
+Consanguinity يعني زواج أقارب ماشي لما تحط إنه
+
+547
+00:57:53,110 --> 00:57:57,090
+مثلًا من العائلة هذه الذكر والأنثى هذولة مثلًا
+
+548
+00:57:57,650 --> 00:58:03,410
+تنزلك خطين بهذا الشكل وبينهم بعدين خط بالنص
+
+549
+00:58:03,410 --> 00:58:08,010
+«monozygotic twins» «monozygotic» يعني توائم
+
+550
+00:58:08,010 --> 00:58:16,850
+متطابقة فبتكون من نفس الجنس وبيكون متطابقين، نحطها
+
+551
+00:58:16,850 --> 00:58:22,900
+هكذا إذا «dizygotic twins» ممكن يكون واحدذاكر واحد
+
+552
+00:58:22,900 --> 00:58:27,520
+أنثى مثلًا توقم واحد ذكر واحد أنثى أو إثنينهم إناث
+
+553
+00:58:27,520 --> 00:58:32,900
+أو إثنينهم ذكور بيصير بس بنحطها بهذا الشكل يعني مش
+
+554
+00:58:32,900 --> 00:58:38,300
+زي الصورة هذه هنا العيلة هذه مثلًا الأب والأم
+
+555
+00:58:38,300 --> 00:58:42,860
+جابوا الطفل الأول ذكر بعدين الطفل الثاني كانت أنثى
+
+556
+00:58:42,860 --> 00:58:47,560
+يعني بهذا الشكل جابوه محمال مختلفة فبنحط من نفس
+
+557
+00:58:47,560 --> 00:58:56,630
+المصدر بيكون في نفس الحملماشي إذا كان فيه عدم ..
+
+558
+00:58:56,630 --> 00:59:04,150
+يعني عدم تأكد من نوعية الـ Zygote يعني هل هو توائم
+
+559
+00:59:04,150 --> 00:59:08,330
+متطابقة أو لغير متطابقة الواحد بحق علامة استفهام
+
+560
+00:59:08,330 --> 00:59:17,410
+إذا ما عنده يعني ثقة 100% Stillbirth اللي هو وفاة
+
+561
+00:59:17,410 --> 00:59:27,200
+في آخر الحملبحيث أنه يكون مبين ذكره لأنثى وبينحط
+
+562
+00:59:27,200 --> 00:59:34,200
+عليه علامة خط ماشي بهذا الشكل still birth وبكون
+
+563
+00:59:34,200 --> 00:59:40,500
+يعني وفاة في أواخر الحمل بكون مرحلة متقدمة adopted
+
+564
+00:59:40,500 --> 00:59:46,400
+into the family بهذا الشكلالحالة اللي هو التبني
+
+565
+00:59:46,400 --> 00:59:52,260
+يعني شخص مادة الوراثية مش من هذه العائلة بس اتبنته
+
+566
+00:59:52,260 --> 00:59:58,080
+هذه العائلة adopted out of the family يعني حاطين
+
+567
+00:59:58,080 --> 01:00:06,620
+هنا الفروقات شكل الخط اللي يعني حاطينه للعلاقة
+
+568
+01:00:06,620 --> 01:00:12,720
+العائلة هذه بهذا الإنسان هنا ذكر هنا أنتهنا
+
+569
+01:00:12,720 --> 01:00:19,400
+الأمثلة أخدت عائلة ثانية وهنا العائلة أخدت بكر من
+
+570
+01:00:19,400 --> 01:00:28,060
+عائلة أخرى pregnancy with information on details
+
+571
+01:00:28,060 --> 01:00:33,700
+if available يعني حالياً في حمل بس احنا مش عارفين
+
+572
+01:00:33,700 --> 01:00:42,730
+يعني لسه ماولدت هي last menstrual periodتاريخ أو
+
+573
+01:00:42,730 --> 01:00:47,730
+أنه حامل على أربع وعشرين أسبوع من أربعين أسبوع
+
+574
+01:00:47,730 --> 01:00:53,070
+لحمل تسعة شهر أو أنه آخر يوم في الدورة في هذا
+
+575
+01:00:53,070 --> 01:00:57,550
+الحمل بتاريخ أتنين، أشرين، أتناش، ألفين واربعتاش
+
+576
+01:00:57,550 --> 01:01:02,570
+مثلاً، فإذا كان يعني عندنا details عن ال pregnancy
+
+577
+01:01:02,570 --> 01:01:07,510
+بنحطها بهذا الشكل الآن هذه بيسموها الـ Pedigree
+
+578
+01:01:07,510 --> 01:01:14,300
+اللي هو اللي بيكون بهذا الشكللما نحط الـ Times
+
+579
+01:01:14,300 --> 01:01:19,100
+Roman في هذا الشكل اللي هو الأجيال، هذا الجيل
+
+580
+01:01:19,100 --> 01:01:23,040
+الأول، هذا الجيل الثاني، هذا الجيل الثالث، الرابع،
+
+581
+01:01:23,040 --> 01:01:29,500
+قدر ما بدي بحط الشخص الأول هنا، الجيل الأول مثلا
+
+582
+01:01:29,500 --> 01:01:34,950
+الذكر، و بعدين زوجته، و بعدين هنا الجيل الثانيذاكر
+
+583
+01:01:34,950 --> 01:01:39,390
+ولد الأول وبعدين البنت الثانية والبنت الثالثة
+
+584
+01:01:39,390 --> 01:01:44,610
+البنت الثانية هي المصابة أحياناً الـ broadband
+
+585
+01:01:44,610 --> 01:01:50,250
+اللي هو الشخص اللي خلانا نكتشف المشكلة في هذه
+
+586
+01:01:50,250 --> 01:01:54,010
+العائلة أو خلانا ندرس هذا الموضوع في هذه العائلة
+
+587
+01:01:54,010 --> 01:02:00,030
+يعني ممكن مثلا أنا أجيإنسان مثلًا إندونازف يعمل له
+
+588
+01:02:00,030 --> 01:02:03,670
+الـ Bt و الـ Btt و يشوف أن هي طالع عنده هموفيليا
+
+589
+01:02:04,110 --> 01:02:09,050
+الـ Hemophilia Ex-Linked Recessive اكتشفتها هنا
+
+590
+01:02:09,050 --> 01:02:13,230
+بعدين باجي بدقيق الأهل آه والله أخواله في عندهم
+
+591
+01:02:13,230 --> 01:02:17,870
+كان فيهم مشكلة معينة بصير بعدين يطلع و بعدين أخوال
+
+592
+01:02:17,870 --> 01:02:22,570
+أمه في بلد ثاني مابيعرفوش عنها يمكن يكون شخص مصاب
+
+593
+01:02:22,570 --> 01:02:28,450
+فكل ما يعني نكتشف أكثر بنضيف أفراد و حالات و شو
+
+594
+01:02:28,450 --> 01:02:34,770
+وضعهمولما انا اكون الشخص اللي بدأت في الاهتمام في
+
+595
+01:02:34,770 --> 01:02:38,710
+هذه القصة بنسميه الـ Proband اللي هو الشخص اللي
+
+596
+01:02:38,710 --> 01:02:45,770
+بدأنا فيه القصة Arrow indicates consulted seeking
+
+597
+01:02:45,770 --> 01:02:53,520
+counselingهنا راح نحكي مثلًا مثال شغلات بتخوف وبظل
+
+598
+01:02:53,520 --> 01:02:58,880
+الواحد لما تصير يصير قلقان بدي يفحص الجينات عشان
+
+599
+01:02:58,880 --> 01:03:05,580
+يشوف هل أنا مصاب، هل في احتمالية إصابتي، كم نسبة
+
+600
+01:03:05,580 --> 01:03:12,600
+لغيري، كذا كذافإذا شخص لسه بده يعرف هل هو هيصاب أو
+
+601
+01:03:12,600 --> 01:03:18,060
+لا يصاب أو كذا بنحطه سهم بهذا الشكل إذا سهم على
+
+602
+01:03:18,060 --> 01:03:26,620
+يعني فراغ مصمت باللون الأزرق كامل بهذا الشكل فهو
+
+603
+01:03:26,620 --> 01:03:31,080
+مصاب وهنا الـ Proband اللي هو يعني بدأت الدراسة
+
+604
+01:03:31,080 --> 01:03:38,430
+عليهإذا هنا فهو شخص يأتي يستفتي عشان يسأل هل أنا
+
+605
+01:03:38,430 --> 01:03:43,350
+سأصاب ولا لأ، بدي أعيش و أضغط، فبحطه على شكل بهذا
+
+606
+01:03:43,350 --> 01:03:49,110
+الشكل، إذا شخصين ما كان عندهم ضرية، no offspring،
+
+607
+01:03:49,110 --> 01:03:55,780
+بنحطها بهذا الشكل، وإذا واحد اتزوج زوجتين،فبتقول
+
+608
+01:03:55,780 --> 01:03:59,980
+الزوج الأولى وهذه الزوج الثانية نحطهم بهذا الشكل
+
+609
+01:03:59,980 --> 01:04:08,820
+إذا صار إجهاض مش spontaneous يعني إجهاض زي في دول
+
+610
+01:04:08,820 --> 01:04:13,870
+ثانية أو في أوضاع ثانيةبكون المرأة حقًا تجد حالها
+
+611
+01:04:13,870 --> 01:04:18,510
+فبتصير يعني إنه Termination of Pregnancy بتبروها
+
+612
+01:04:18,510 --> 01:04:24,510
+في بعض المجتمعات حق للأنثى بشو اسمه؟ بيكون إنه
+
+613
+01:04:24,510 --> 01:04:30,410
+بتحطها بهذا الشكل، ماشي فهي مجمل يعني أنا بعتبر
+
+614
+01:04:30,410 --> 01:04:40,450
+مهم كثير لحضراتكم إنه الواحد يعرف وينتبهويميز شو
+
+615
+01:04:40,450 --> 01:04:46,250
+معنى كل رمز من الرموز هذه في الـ Pedigree اللي
+
+616
+01:04:46,250 --> 01:04:50,030
+لازم نرسمه وراح نلاحظ بعدين لما تتطلع على الـ
+
+617
+01:04:50,030 --> 01:04:55,830
+Pedigree وتشوف يعني كيف شكله وشو هو تقدر تحدد أنه
+
+618
+01:04:55,830 --> 01:05:02,620
+المتوقع طبيعة الورافة للمرض اللي أنت بتتكلم عنههذه
+
+619
+01:05:02,620 --> 01:05:12,180
+هنا يعني مثلًا عائلة طرينا ندرسها من خمس أجيال،
+
+620
+01:05:12,180 --> 01:05:19,720
+ماشي؟ الشخص المصاب اللي هي أنثى هي عبارة عن اللي
+
+621
+01:05:19,720 --> 01:05:28,080
+عليها السهم بهذا الشكل، ماشي؟ هنا هي مصابة وهي
+
+622
+01:05:28,080 --> 01:05:34,570
+اللي يعني بدأت اهتمامنا بهذه العائلةطبعًا متزوجي
+
+623
+01:05:34,570 --> 01:05:48,030
+رجل طبيعي، أبيض، وخلفت منه تلت أفراد، بنت وولدين،
+
+624
+01:05:48,030 --> 01:05:54,190
+عندهم المشكلة هذه، يعني زي أمهم طالعين هيك، حاطين
+
+625
+01:05:54,190 --> 01:06:01,170
+هنا ال .. يعني ال .. ال .. ال .. لما نتكلم
+
+626
+01:06:03,530 --> 01:06:09,450
+عن الشخص المصاب اللي هو هنا، ماشي؟ لما نتكلم عن
+
+627
+01:06:09,450 --> 01:06:17,590
+الشخص المصاب هنا اللي عليها السهم، ماشي؟ لما نحطه
+
+628
+01:06:17,590 --> 01:06:21,710
+جنبها واحد، فهي اللي يسموها الـ First-degree
+
+629
+01:06:21,710 --> 01:06:26,650
+relative يعني قرابة من الدرجة الأولى، مين أقربها
+
+630
+01:06:26,650 --> 01:06:32,250
+الإنسان الدرجة الأولى؟ أول شيء، أبوه وأمه، ماشي؟
+
+631
+01:06:32,660 --> 01:06:37,140
+فهي بالـ Third Generation إذا بتنتبهوا هنا هذا
+
+632
+01:06:37,140 --> 01:06:41,640
+والدها وهذه أمها فهذا بنعتبرها First Degree
+
+633
+01:06:41,640 --> 01:06:48,160
+أخوانها وخواتها برضه First Degree ولادها وبناتها
+
+634
+01:06:48,160 --> 01:06:54,400
+First Degree فدولة يعني هنا لما نيجي نتكلم يعني
+
+635
+01:06:54,400 --> 01:06:58,820
+مثلا على الـ Risk للـ Atherosclerosis المفروض كلمة
+
+636
+01:06:58,820 --> 01:07:04,120
+دايما بحكيها للطلاب إنهاإنه والله واحد يقول لي إبن
+
+637
+01:07:04,120 --> 01:07:08,120
+عمي صابه مشكلة قلب على عمره صغير، هاي مش risk
+
+638
+01:07:08,120 --> 01:07:11,060
+factor له، مش first degree، مش اللي هي اللي
+
+639
+01:07:11,060 --> 01:07:13,280
+بيسموها الـ major risk factors لأولاد الـ
+
+640
+01:07:13,280 --> 01:07:20,940
+sclerosis، هاي تعتبر minor risk factor أو مش لأنها
+
+641
+01:07:20,940 --> 01:07:24,260
+first degree relative فاللي حاطين عليهم واحد
+
+642
+01:07:24,260 --> 01:07:29,760
+حوالين البنت هذه، ماشي، هاي first degree relative
+
+643
+01:07:30,400 --> 01:07:37,700
+انتبهوا إن زوجها وجوز بنتها لا تعتبر قرابي بينهم
+
+644
+01:07:37,700 --> 01:07:43,300
+وبينها، ماشي؟ فدولة مافيش قرابي بينها وبينها، لما
+
+645
+01:07:43,300 --> 01:07:50,040
+نيجي ناخد جيل أبكر من ذلك، مثلا الجدود، هدولة
+
+646
+01:07:50,040 --> 01:07:56,940
+second degree relative، ولاد العم، يعني الـ، آسف،
+
+647
+01:07:56,940 --> 01:08:05,200
+هنا، هي هنا المصابة،ماشي هذا أبوها إذا هاي عمتها
+
+648
+01:08:05,200 --> 01:08:14,720
+هنا هاي أمها يبقى هذا خالها الخال والعم مثلا
+
+649
+01:08:14,720 --> 01:08:21,200
+second degree relative ماشي الحفيد second degree
+
+650
+01:08:21,200 --> 01:08:27,200
+relative ماشي ال .. بالنسبة لل third degree
+
+651
+01:08:27,200 --> 01:08:33,830
+relative يعني كل ما ببعددرجة بثير باعتبره درجة
+
+652
+01:08:33,830 --> 01:08:43,250
+القرابة وقوة التطابق في المادة الوراثية يعني ماشي
+
+653
+01:08:43,250 --> 01:08:49,070
+فمن
+
+654
+01:08:49,070 --> 01:08:56,490
+الأشياء اللي يعني هيك بشكل واضح منديلية
+
+655
+01:08:57,010 --> 01:09:03,470
+الفصيلة الدم الـ ABO blood group الماشي الـ ABO
+
+656
+01:09:03,470 --> 01:09:10,430
+blood group لما نتكلم على مستوى الـ Genotype يعني
+
+657
+01:09:10,430 --> 01:09:15,950
+على مستوى الأليلز الموجودة في الـ DNA اللي موجودة
+
+658
+01:09:15,950 --> 01:09:22,710
+في هذا الـ locus بتلاقي الاحتمالات في ثلاث أليلز،
+
+659
+01:09:22,710 --> 01:09:29,530
+الـ O والـ A والـ Bوالإنسان يا إما OO أو AB أو AA
+
+660
+01:09:29,530 --> 01:09:36,770
+أو AB أو BB أو BO أو AO يعني بهذه الإحتمالات الـ
+
+661
+01:09:36,770 --> 01:09:41,970
+Phenotype بين البشر اللي أنا بلاقيهم إذا OO راح
+
+662
+01:09:41,970 --> 01:09:48,630
+يطلع O إذا AB فيه Co-dominant يعني هذه مبدأ إن
+
+663
+01:09:48,630 --> 01:09:55,220
+أثنين أقوياء وظاهرين أثنينهم dominant على الـ Oبس
+
+664
+01:09:55,220 --> 01:10:00,640
+إذا اثنين كان «A» و «B» إثنين بيبينوا «A» «B» فهي
+
+665
+01:10:00,640 --> 01:10:07,080
+بتكون طبعاً إذا «AA» أو «AO» بيبين Phenotype «A»
+
+666
+01:10:07,080 --> 01:10:12,200
+إذا «BB» أو «BO» بيبين Phenotype «B» هذولة الـ
+
+667
+01:10:12,200 --> 01:10:18,580
+Phenotype on RBCs يعني هذولة الـ Antigen هذولة
+
+668
+01:10:18,580 --> 01:10:24,040
+المظهر تبعت الإنسان هذا نتيجة هذه الجينات بهذا
+
+669
+01:10:24,040 --> 01:10:30,960
+الشكللو جيت أنا أشوف الـ Anti-A وAnti-B اللي بحطه
+
+670
+01:10:30,960 --> 01:10:37,700
+لما قاعد أفحص الـ الـ blood group، ماشي بحط نقطة
+
+671
+01:10:37,700 --> 01:10:42,420
+الـ Anti-A وAnti-B وبسوي وبعدين بحر هن هيكي وعشان
+
+672
+01:10:42,420 --> 01:10:46,800
+أشوف ده فيه agglutination وبكون معناته positive،
+
+673
+01:10:46,800 --> 01:10:51,220
+فيه reaction إذا مافيه reaction للإثنين، بكون O
+
+674
+01:10:51,220 --> 01:10:57,410
+إذا كانت reaction للـA بس، فهو Aبس جينياً ياما AA
+
+675
+01:10:57,410 --> 01:11:03,250
+أو AO إذا بي بس، يعني بي، الـ Blood Group، يا BB
+
+676
+01:11:03,250 --> 01:11:10,730
+يا BO إذا اشترك بالإثنين، بتكون AB، لهذا الشكل،
+
+677
+01:11:10,730 --> 01:11:20,830
+فدولا بالـ Test، ماشي، بعد عمر السنةيعني الـ
+
+678
+01:11:20,830 --> 01:11:25,270
+Antigens للـ ABO Blood Group بتكون مش بس على الـ
+
+679
+01:11:25,270 --> 01:11:27,450
+Red Blood Cells اللي أهم من الـ Red Blood Cells
+
+680
+01:11:27,450 --> 01:11:32,090
+موجودة على الـ Endothelium موجودة على غشاء الطبقة
+
+681
+01:11:32,090 --> 01:11:37,030
+المبطنة للأوعي الدموية فهي أهم من الـ Red Blood
+
+682
+01:11:37,030 --> 01:11:41,590
+Cells بس طبعاً احنا اكتشفناهم على تأثيرهم على الـ
+
+683
+01:11:41,590 --> 01:11:49,280
+Red Blood Cells فبعد عمر السنةبظهر في الإنسان بالـ
+
+684
+01:11:49,280 --> 01:11:53,780
+Antibodies اللي موجودة في الـ Serum فاللي عنده AB
+
+685
+01:11:53,780 --> 01:11:58,480
+Blood Group ماعندوش أي نوع Antibodies ضد الـ A ولا
+
+686
+01:11:58,480 --> 01:12:04,200
+ضد الـ B إذا عنده B Blood Group راح يتكون في جسمه
+
+687
+01:12:04,200 --> 01:12:09,480
+Anti-A وإذا عنده Blood Group A بتكون الـ Anti-B
+
+688
+01:12:09,480 --> 01:12:15,850
+وإذا عنده Oبيتكون A وB، Anti-A وAnti-B طبعاً هذولة
+
+689
+01:12:15,850 --> 01:12:20,310
+مبادئ أهميتهم أولاً في الـBlood Transfusion أمتى
+
+690
+01:12:20,310 --> 01:12:26,350
+بقدر أعطي دم الإنسان لإنسان، لازم مافي مجال أعطيه
+
+691
+01:12:26,350 --> 01:12:34,130
+كرات دم حمر يكون في جسمه أجسام مضادة ضدهم وبالتالي
+
+692
+01:12:34,130 --> 01:12:41,890
+تعمل reaction وتعمل مشكلة كبيرة كثيرأنا مضطر أن
+
+693
+01:12:41,890 --> 01:12:50,750
+أقف هنا و بنكمل الأسبوع الجاي، في أسئلة؟
+
+694
+01:12:50,750 --> 01:12:57,850
+في أسئلة؟ إذا في أسئلة عندكم يا دكاترة، فيا ..
+
+695
+01:12:57,850 --> 01:13:01,670
+يعني يا بت .. بتسألوها أو بتبعتوها رسالة، رسالة
+
+696
+01:13:01,670 --> 01:13:06,170
+يعني نعم، نعم، ماشي
+
+697
+01:13:07,180 --> 01:13:12,860
+الله يوفقكم و باعتدر اليوم يعني غير شكل كان عندي
+
+698
+01:13:12,860 --> 01:13:17,820
+شغل إيماني عارف هيك الحمد لله على كل حالة الله
+
+699
+01:13:17,820 --> 01:13:19,960
+يعطيك الخير يا دكتور الله يعطيك الخير يا دكتور
+
+700
+01:13:19,960 --> 01:13:20,640
+الله يعطيك الخير يا دكتور الله يعطيك الخير يا
+
+701
+01:13:20,640 --> 01:13:20,880
+دكتور الله يعطيك الخير يا دكتور الله يعطيك الخير
+
+702
+01:13:20,880 --> 01:13:20,900
+يا دكتور الله يعطيك الخير يا دكتور الله يعطيك
+
+703
+01:13:20,900 --> 01:13:21,160
+الخير يا دكتور الله يعطيك الخير يا دكتور الله
+
+704
+01:13:21,160 --> 01:13:22,880
+يعطيك الخير يا دكتور الله يعطيك الخير يا دكتور
+
+705
+01:13:22,880 --> 01:13:24,160
+الله يعطيك الخير يا دكتور الله يعطيك الخير يا
+
+706
+01:13:24,160 --> 01:13:25,560
+دكتور الله يعطيك الخير يا دكتور الله يعطيك الخير
+
+707
+01:13:25,560 --> 01:13:25,800
+يا دكت
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/QjHQ6ziYtVc_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/QjHQ6ziYtVc_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..c8ddf12cf26ce034b991249fa98a9822f30c1249
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/QjHQ6ziYtVc_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2816, "start": 0.0, "end": 28.16, "text": "بسم الله الرحمن الرحيم في المحاضرة السابقة كنا نتكلم عن تركيب الـ DNA والمادة الأورافية وكيف هي موجودة في خلايانا ووصلنا ووقفنا شوية عند هذه الصورة واتناقشنا فيها شوية، اللي هي", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 8978, 9673, 5016, 46958, 25720, 21136, 16758, 28671, 9122, 8315, 8717, 2655, 4117, 19528, 18871, 6055, 31747, 1829, 3555, 2423, 39184, 8272, 16070, 15042, 41891, 16247, 13063, 31845, 10632, 4032, 4117, 33911, 39896, 3714, 29245, 23328, 3660, 8978, 16490, 15040, 1829, 7649, 995, 4032, 2407, 36520, 8315, 4032, 30543, 5172, 8315, 13412, 2407, 10632, 43242, 29538, 31767, 13063, 3660, 4032, 9307, 8315, 4587, 8592, 8315, 8978, 11296, 13412, 2407, 10632, 12399, 13672, 1829, 39896], "avg_logprob": -0.16127231415538562, "compression_ratio": 1.7722222222222221, "no_speech_prob": 5.424022674560547e-06, "words": [{"start": 0.0, "end": 2.62, "word": "بسم", "probability": 0.8505859375}, {"start": 2.62, "end": 2.82, "word": " الله", "probability": 0.96533203125}, {"start": 2.82, "end": 3.26, "word": " الرحمن", "probability": 0.97412109375}, {"start": 3.26, "end": 3.74, "word": " الرحيم", "probability": 0.99365234375}, {"start": 3.74, "end": 4.96, "word": " في", "probability": 0.2191162109375}, {"start": 4.96, "end": 6.0, "word": " المحاضرة", "probability": 0.970947265625}, {"start": 6.0, "end": 6.9, "word": " السابقة", "probability": 0.9900716145833334}, {"start": 6.9, "end": 7.32, "word": " كنا", "probability": 0.914794921875}, {"start": 7.32, "end": 8.02, "word": " نتكلم", "probability": 0.987060546875}, {"start": 8.02, "end": 9.3, "word": " عن", "probability": 0.95263671875}, {"start": 9.3, "end": 12.24, "word": " تركيب", "probability": 0.9022216796875}, {"start": 12.24, "end": 12.48, "word": " الـ", "probability": 0.946044921875}, {"start": 12.48, "end": 12.98, "word": " DNA", "probability": 0.242919921875}, {"start": 12.98, "end": 13.82, "word": " والمادة", "probability": 0.7459309895833334}, {"start": 13.82, "end": 14.7, "word": " الأورافية", "probability": 0.8072509765625}, {"start": 14.7, "end": 15.38, "word": " وكيف", "probability": 0.837890625}, {"start": 15.38, "end": 15.78, "word": " هي", "probability": 0.80615234375}, {"start": 15.78, "end": 18.22, "word": " موجودة", "probability": 0.951416015625}, {"start": 18.22, "end": 18.38, "word": " في", "probability": 0.97802734375}, {"start": 18.38, "end": 19.28, "word": " خلايانا", "probability": 0.8091796875}, {"start": 19.28, "end": 21.52, "word": " ووصلنا", "probability": 0.9036865234375}, {"start": 21.52, "end": 22.7, "word": " ووقفنا", "probability": 0.73028564453125}, {"start": 22.7, "end": 23.24, "word": " شوية", "probability": 0.7919921875}, {"start": 23.24, "end": 23.86, "word": " عند", "probability": 0.89404296875}, {"start": 23.86, "end": 24.98, "word": " هذه", "probability": 0.8525390625}, {"start": 24.98, "end": 25.66, "word": " الصورة", "probability": 0.9920247395833334}, {"start": 25.66, "end": 26.54, "word": " واتناقشنا", "probability": 0.892578125}, {"start": 26.54, "end": 26.82, "word": " فيها", "probability": 0.9794921875}, {"start": 26.82, "end": 27.68, "word": " شوية،", "probability": 0.8282470703125}, {"start": 27.68, "end": 27.76, "word": " اللي", "probability": 0.84228515625}, {"start": 27.76, "end": 28.16, "word": " هي", "probability": 0.9755859375}], "temperature": 1.0}, {"id": 2, "seek": 5248, "start": 28.74, "end": 52.48, "text": "يعني حاطين فيها مبادئ إنه داخل الـ Chromosome بيكون الـ DNA على شكل اللي هو الـ Double Helix السلم اللولبي وإنه لما نحنا نيجي نتعامل معاه دائما ناخد الأصل اللي يكون اللي هو القطعة اللي ماشية من الجهة", "tokens": [40228, 22653, 11331, 41193, 9957, 8978, 11296, 3714, 3555, 18513, 19986, 36145, 3224, 11778, 47283, 1211, 2423, 39184, 1721, 40934, 423, 4724, 1829, 30544, 2423, 39184, 8272, 15844, 13412, 28820, 13672, 1829, 31439, 2423, 39184, 16633, 6128, 970, 21136, 19528, 13672, 12610, 21292, 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{"start": 32.64, "end": 33.46, "word": " Chromosome", "probability": 0.7421875}, {"start": 33.46, "end": 35.1, "word": " بيكون", "probability": 0.6153971354166666}, {"start": 35.1, "end": 35.76, "word": " الـ", "probability": 0.98583984375}, {"start": 35.76, "end": 36.14, "word": " DNA", "probability": 0.79443359375}, {"start": 36.14, "end": 36.52, "word": " على", "probability": 0.89892578125}, {"start": 36.52, "end": 37.08, "word": " شكل", "probability": 0.991455078125}, {"start": 37.08, "end": 37.78, "word": " اللي", "probability": 0.9658203125}, {"start": 37.78, "end": 37.92, "word": " هو", "probability": 0.99560546875}, {"start": 37.92, "end": 38.08, "word": " الـ", "probability": 0.97314453125}, {"start": 38.08, "end": 38.3, "word": " Double", "probability": 0.69677734375}, {"start": 38.3, "end": 38.88, "word": " Helix", "probability": 0.938232421875}, {"start": 38.88, "end": 39.4, "word": " السلم", "probability": 0.5372314453125}, {"start": 39.4, "end": 40.06, "word": " اللولبي", 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"probability": 0.884765625}, {"start": 777.98, "end": 778.42, "word": " هذه", "probability": 0.93994140625}, {"start": 778.42, "end": 779.02, "word": " كانت", "probability": 0.98828125}, {"start": 779.02, "end": 780.16, "word": " واحدة", "probability": 0.98388671875}, {"start": 780.16, "end": 781.1, "word": " تضاعف", "probability": 0.763275146484375}, {"start": 781.1, "end": 781.72, "word": " الـ", "probability": 0.916259765625}, {"start": 781.72, "end": 782.12, "word": " DNA", "probability": 0.400390625}, {"start": 782.12, "end": 782.44, "word": " اللي", "probability": 0.98828125}, {"start": 782.44, "end": 782.96, "word": " فيها", "probability": 0.995361328125}, {"start": 782.96, "end": 784.32, "word": " فبعد", "probability": 0.9000651041666666}, {"start": 784.32, "end": 784.88, "word": " ذلك", "probability": 0.99658203125}, {"start": 784.88, "end": 785.98, "word": " انقسمت", "probability": 0.965087890625}, {"start": 785.98, "end": 786.46, "word": " نص", "probability": 0.965087890625}, {"start": 786.46, "end": 786.76, "word": " إلى", "probability": 0.4990234375}, {"start": 786.76, "end": 787.5, "word": " خليتين", "probability": 0.8834228515625}], "temperature": 1.0}, {"id": 30, "seek": 81579, "start": 788.35, "end": 815.79, "text": "والسبب في الانقسام أنه هناك راح يكون حاجة نحكي عنها «سينتروزوم» مش «سينترومير»، «سينتروزوم» بيكون بالطرف من الجهتين الخليتين اللي راح يتكونوا وراح يتم جد الـ «كرومزومات» أو الـ «كروماتيد» لكل طرف عن طريق اللي هم يعني الـ Spindle Fibers بقولهم", "tokens": [2407, 6027, 35457, 3555, 8978, 2423, 7649, 4587, 3794, 10943, 14739, 3224, 34105, 4117, 12602, 39319, 7251, 30544, 11331, 26108, 3660, 8717, 5016, 4117, 1829, 18871, 11296, 4657, 3794, 9957, 2655, 2288, 2407, 11622, 20498, 5933, 37893, 4657, 3794, 9957, 2655, 2288, 20498, 13546, 5933, 12399, 4657, 3794, 9957, 2655, 2288, 2407, 11622, 20498, 5933, 4724, 1829, 30544, 20666, 9566, 28480, 9154, 25724, 3224, 2655, 9957, 33962, 20292, 2655, 9957, 13672, 1829, 12602, 39319, 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"text": "وبيشبكوا ما بين الـ Centrosome مع الـ Centromere حتى يفصل الـ DNA إلى نصفين متساوية، واضحة؟ فالـ Centromere هو قطعة في الـ DNA، في الـ Chromosome وظيفتها تسهيل والتحكم في عملية فصل نصفي", "tokens": [2407, 21292, 8592, 3555, 4117, 14407, 19446, 49374, 2423, 39184, 3408, 2635, 423, 20449, 2423, 39184, 3408, 4397, 323, 11331, 49975, 7251, 5172, 36520, 2423, 39184, 8272, 30731, 8717, 9381, 5172, 9957, 44650, 3794, 995, 2407, 10632, 12399, 4032, 46958, 5016, 3660, 22807, 6156, 6027, 39184, 3408, 4397, 323, 31439, 12174, 9566, 27884, 8978, 2423, 39184, 8272, 12399, 8978, 2423, 39184, 1721, 40934, 423, 4032, 19913, 33911, 2655, 11296, 6055, 3794, 3224, 26895, 16070, 2655, 5016, 24793, 8978, 6225, 42213, 10632, 6156, 36520, 8717, 9381, 41185], "avg_logprob": -0.09572557248603339, "compression_ratio": 1.6404494382022472, "no_speech_prob": 4.172325134277344e-07, "words": [{"start": 816.28, "end": 817.38, "word": "وبيشبكوا", "probability": 0.8738199869791666}, {"start": 817.38, "end": 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"probability": 0.8841145833333334}, {"start": 838.42, "end": 840.0, "word": " وظيفتها", "probability": 0.92958984375}, {"start": 840.0, "end": 840.94, "word": " تسهيل", "probability": 0.9927978515625}, {"start": 840.94, "end": 842.2, "word": " والتحكم", "probability": 0.9637451171875}, {"start": 842.2, "end": 842.5, "word": " في", "probability": 0.97802734375}, {"start": 842.5, "end": 843.16, "word": " عملية", "probability": 0.9793294270833334}, {"start": 843.16, "end": 844.1, "word": " فصل", "probability": 0.9423828125}, {"start": 844.1, "end": 845.36, "word": " نصفي", "probability": 0.9876302083333334}], "temperature": 1.0}, {"id": 32, "seek": 87469, "start": 845.89, "end": 874.69, "text": "الـ Chromosomes إلى طرفي الخلية المنقسمة، ماشي؟ لسه برضه النقطة يبدو أنها ما واضحة تقريبا راح نشوفها بعدين بشكل تفصيلي، يعني الآن مش راسمينها، بس راح تيجي مرة ثانية، ماشي؟ راح نشوفها كثير، إشي ضروري عشان نقدر نفصلهم، يعني إذا أنا مثلا عندي Top 10 خيط", "tokens": [6027, 39184, 1721, 40934, 18168, 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846.51, "word": "الـ", "probability": 0.80517578125}, {"start": 846.51, "end": 847.13, "word": " Chromosomes", "probability": 0.5572916666666666}, {"start": 847.13, "end": 847.67, "word": " إلى", "probability": 0.85009765625}, {"start": 847.67, "end": 848.95, "word": " طرفي", "probability": 0.7965494791666666}, {"start": 848.95, "end": 849.83, "word": " الخلية", "probability": 0.96240234375}, {"start": 849.83, "end": 851.67, "word": " المنقسمة،", "probability": 0.8608805338541666}, {"start": 851.67, "end": 852.47, "word": " ماشي؟", "probability": 0.7818603515625}, {"start": 852.47, "end": 853.33, "word": " لسه", "probability": 0.6476236979166666}, {"start": 853.33, "end": 853.55, "word": " برضه", "probability": 0.93212890625}, {"start": 853.55, "end": 853.99, "word": " النقطة", "probability": 0.97314453125}, {"start": 853.99, "end": 854.25, "word": " يبدو", "probability": 0.9303385416666666}, {"start": 854.25, "end": 854.51, "word": " أنها", "probability": 0.814208984375}, {"start": 854.51, "end": 854.67, "word": " ما", "probability": 0.85888671875}, {"start": 854.67, "end": 855.23, "word": " واضحة", "probability": 0.7874755859375}, {"start": 855.23, "end": 855.41, "word": " تقريبا", "probability": 0.655810546875}, {"start": 855.41, "end": 855.87, "word": " راح", "probability": 0.7110595703125}, {"start": 855.87, "end": 856.37, "word": " نشوفها", "probability": 0.984375}, {"start": 856.37, "end": 857.03, "word": " بعدين", "probability": 0.8486328125}, {"start": 857.03, "end": 857.87, "word": " بشكل", "probability": 0.95947265625}, {"start": 857.87, "end": 858.61, "word": " تفصيلي،", "probability": 0.8444010416666666}, {"start": 858.61, "end": 858.77, "word": " يعني", "probability": 0.980224609375}, {"start": 858.77, "end": 859.13, "word": " الآن", "probability": 0.629638671875}, {"start": 859.13, "end": 859.39, "word": " مش", "probability": 0.98828125}, {"start": 859.39, "end": 860.55, "word": " راسمينها،", "probability": 0.7969563802083334}, {"start": 860.55, 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"word": " الظواهر", "probability": 0.947265625}, {"start": 1060.27, "end": 1060.43, "word": " اللي", "probability": 0.903564453125}, {"start": 1060.43, "end": 1061.43, "word": " بتحدث", "probability": 0.7197265625}, {"start": 1061.43, "end": 1061.59, "word": " أو", "probability": 0.95458984375}, {"start": 1061.59, "end": 1061.95, "word": " بتبدأ", "probability": 0.9168294270833334}, {"start": 1061.95, "end": 1062.33, "word": " تحدث", "probability": 0.9580078125}, {"start": 1062.33, "end": 1063.15, "word": " بالـProphase", "probability": 0.7998046875}, {"start": 1063.15, "end": 1065.31, "word": " الـProphase", "probability": 0.928955078125}, {"start": 1065.31, "end": 1065.89, "word": " بعدها", "probability": 0.56103515625}, {"start": 1065.89, "end": 1066.33, "word": " بتدخل", "probability": 0.921875}, {"start": 1066.33, "end": 1067.67, "word": " بالـPrometaphase", "probability": 0.8426920572916666}, {"start": 1067.67, "end": 1070.25, "word": " بيصير", "probability": 0.9224853515625}, 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عام", "tokens": [41185, 8608, 33604, 6027, 9154, 11778, 4117, 2655, 13063, 3660, 4032, 1829, 7435, 3215, 7649, 8978, 8717, 47432, 3660, 2423, 39184, 47, 15276, 21329, 37495, 22653, 8032, 1211, 2423, 39184, 47, 15276, 21329, 31439, 8717, 36178, 33251, 13063, 3555, 3794, 2423, 2407, 31371, 10943, 22807, 20193, 23032, 3555, 3615, 995, 12399, 37495, 22653, 29538, 36764, 24401, 3660, 15844, 3714, 14851, 2407, 7578, 28239, 2407, 16606, 4032, 14407, 24401, 3660, 15844, 3714, 14851, 2407, 7578, 33962, 15040, 25528, 4724, 8592, 28820, 6225, 10943], "avg_logprob": -0.2268448766455593, "compression_ratio": 1.6627906976744187, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 5075.54, "end": 5075.8, "word": "في", "probability": 0.50439453125}, {"start": 5075.8, "end": 5076.4, "word": " سؤال", "probability": 0.9461263020833334}, {"start": 5076.4, "end": 5078.22, "word": " من", "probability": 0.6484375}, {"start": 5078.22, "end": 5078.64, "word": " دكتورة", "probability": 0.77607421875}, 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تفاصيل", "probability": 0.986083984375}, {"start": 5511.44, "end": 5512.18, "word": " المعلومات", "probability": 0.9908447265625}, {"start": 5512.18, "end": 5512.7, "word": " الخط", "probability": 0.71533203125}, {"start": 5512.7, "end": 5513.86, "word": " الصغير،", "probability": 0.9012451171875}, {"start": 5513.86, "end": 5514.38, "word": " المعلومات", "probability": 0.9901123046875}, {"start": 5514.38, "end": 5515.28, "word": " الكثيرة،", "probability": 0.9100341796875}, {"start": 5515.28, "end": 5515.52, "word": " يعني", "probability": 0.93994140625}, {"start": 5515.52, "end": 5516.22, "word": " هي", "probability": 0.88623046875}, {"start": 5516.22, "end": 5517.9, "word": " بتعينك", "probability": 0.9417724609375}, {"start": 5517.9, "end": 5518.12, "word": " على", "probability": 0.9521484375}, {"start": 5518.12, "end": 5518.66, "word": " الفهم", "probability": 0.975341796875}, {"start": 5518.66, "end": 5519.58, "word": " بشكل", "probability": 0.8701171875}, {"start": 5519.58, "end": 5519.94, "word": " اللي", "probability": 0.978515625}, {"start": 5519.94, "end": 5520.58, "word": " يعني", "probability": 0.869140625}, {"start": 5520.58, "end": 5520.78, "word": " من", "probability": 0.98193359375}, {"start": 5520.78, "end": 5521.1, "word": " خلال", "probability": 0.99169921875}, {"start": 5521.1, "end": 5521.3, "word": " زي", "probability": 0.90234375}, {"start": 5521.3, "end": 5521.4, "word": " ما", "probability": 0.99072265625}, {"start": 5521.4, "end": 5521.56, "word": " أنا", "probability": 0.94873046875}, {"start": 5521.56, "end": 5521.88, "word": " بقول", "probability": 0.987060546875}, {"start": 5521.88, "end": 5522.18, "word": " هيك،", "probability": 0.9150390625}, {"start": 5522.18, "end": 5522.62, "word": " بشرح", "probability": 0.93212890625}, {"start": 5522.62, "end": 5523.74, "word": " كيف", "probability": 0.65380859375}, {"start": 5523.74, "end": 5524.18, "word": " تظهر", "probability": 0.815185546875}, {"start": 5524.18, "end": 5524.4, "word": " 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0.90478515625}, {"start": 5528.09, "end": 5528.25, "word": " راح", "probability": 0.982177734375}, {"start": 5528.25, "end": 5528.71, "word": " تكون", "probability": 0.990478515625}, {"start": 5528.71, "end": 5529.69, "word": " يعني", "probability": 0.7421875}, {"start": 5529.69, "end": 5530.55, "word": " إذا", "probability": 0.873779296875}, {"start": 5530.55, "end": 5530.97, "word": " الفاحد", "probability": 0.6451822916666666}, {"start": 5530.97, "end": 5531.33, "word": " فهم", "probability": 0.975341796875}, {"start": 5531.33, "end": 5532.51, "word": " المبدأ", "probability": 0.9736328125}, {"start": 5532.51, "end": 5532.63, "word": " و", "probability": 0.49072265625}, {"start": 5532.63, "end": 5533.19, "word": " القاعدة", "probability": 0.9727783203125}, {"start": 5533.19, "end": 5533.33, "word": " زي", "probability": 0.9462890625}, {"start": 5533.33, "end": 5533.43, "word": " ما", "probability": 0.9677734375}, {"start": 5533.43, "end": 5533.93, "word": " بيقوله", "probability": 0.885009765625}, {"start": 5533.93, "end": 5534.49, "word": " بيقدر", "probability": 0.910400390625}, {"start": 5534.49, "end": 5535.59, "word": " يتكر", "probability": 0.8201497395833334}, {"start": 5535.59, "end": 5536.73, "word": " الأشياء", "probability": 0.9932861328125}, {"start": 5536.73, "end": 5537.21, "word": " بإذن", "probability": 0.68084716796875}, {"start": 5537.21, "end": 5537.43, "word": " الله", "probability": 0.94189453125}, {"start": 5537.43, "end": 5537.83, "word": " تعالى،", "probability": 0.85223388671875}, {"start": 5537.83, "end": 5537.85, "word": " ان", "probability": 0.419677734375}, {"start": 5537.85, "end": 5538.01, "word": " شاء", "probability": 0.942138671875}, {"start": 5538.01, "end": 5538.17, "word": " الله", "probability": 0.966796875}, {"start": 5538.17, "end": 5538.43, "word": " رب", "probability": 0.7213134765625}, {"start": 5538.43, "end": 5539.33, "word": " العالمين،", "probability": 0.83489990234375}, {"start": 5539.33, "end": 5539.75, "word": " 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"word": " إن", "probability": 0.245849609375}, {"start": 5542.87, "end": 5543.07, "word": " شاء", "probability": 0.97412109375}, {"start": 5543.07, "end": 5543.27, "word": " الله", "probability": 0.9609375}, {"start": 5543.27, "end": 5543.53, "word": " رب", "probability": 0.910400390625}, {"start": 5543.53, "end": 5544.19, "word": " العالمين،", "probability": 0.94580078125}, {"start": 5544.19, "end": 5544.65, "word": " نكمل", "probability": 0.7137858072916666}, {"start": 5544.65, "end": 5544.83, "word": " من", "probability": 0.6630859375}, {"start": 5544.83, "end": 5545.49, "word": " هنا،", "probability": 0.91064453125}, {"start": 5545.49, "end": 5545.77, "word": " السلام", "probability": 0.89208984375}, {"start": 5545.77, "end": 5546.65, "word": " عليكم،", "probability": 0.78369140625}, {"start": 5546.65, "end": 5546.83, "word": " السلام", "probability": 0.7412109375}, {"start": 5546.83, "end": 5547.47, "word": " عليكم،", "probability": 0.8600260416666666}, {"start": 5547.47, "end": 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Tl5zcdiL4_o_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Tl5zcdiL4_o_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..89fb89f9cbceab7e9234675b6f5bf103c1ffa90f
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Tl5zcdiL4_o_postprocess.srt
@@ -0,0 +1,3528 @@
+1
+00:00:00,000 --> 00:00:08,880
+تعني بعيدها تقترح عليهم الآن أنا شايف ردود ماشية
+
+2
+00:00:08,880 --> 00:00:19,140
+الأسئلة
+
+3
+00:00:19,140 --> 00:00:26,680
+حول ترتيب الأمور بالنسبة للامتحان وشو أدرس وشو ما
+
+4
+00:00:26,680 --> 00:00:35,310
+أدرسش أجلوهااللي اتكلمنا كثيرًا عن مواضيع إنه أنت
+
+5
+00:00:35,310 --> 00:00:39,930
+هدفك يعني خلّي عينك صحيح أنت أحسن مشغول في العلمات
+
+6
+00:00:39,930 --> 00:00:44,570
+و بتسأل و بدك أحسن علامة و تنافس شديد و كل العالم
+
+7
+00:00:44,570 --> 00:00:50,710
+هيك حتى في جامعتنا و لا في أي مكان بس بالأخير يعني
+
+8
+00:00:50,710 --> 00:00:56,060
+الأهم إنك أنت تطلع فهمانإنك تطلع مستوعب للكلام
+
+9
+00:00:56,060 --> 00:01:03,000
+بحيث إنك تستطيع إنك يعني تتعامل في الحياة بعدين مع
+
+10
+00:01:03,000 --> 00:01:07,000
+هذه المعلومات فخلّينا من هذا مطوع أنا بسأل إذا حد
+
+11
+00:01:07,000 --> 00:01:14,300
+عنده أسئلة عن المادة العلمية مش داخل مش داخل،
+
+12
+00:01:14,300 --> 00:01:19,680
+مطلوب مش مطلوب على قدر طموحك، بدك تتعب حالك، بدك
+
+13
+00:01:19,680 --> 00:01:25,520
+ترتاحإيش اسمه؟ ريح حالك، مافي مشكلة فنرجع مرة
+
+14
+00:01:25,520 --> 00:01:30,680
+ثانية، الآن بتسألت أنا إيش تركيب البروتين فكذا
+
+15
+00:01:30,680 --> 00:01:37,100
+واحد حكالي كتبت بقرا اسمه Primary وفيه ناس كتبوا
+
+16
+00:01:37,100 --> 00:01:43,860
+Amino Acids وفيه ناس كتبوا Secondary وTertiary مش
+
+17
+00:01:43,860 --> 00:01:51,090
+حاطين يعني تفاصيل لهذا الأمرأنا أتمنى بس إنه الـ…
+
+18
+00:01:51,090 --> 00:01:58,910
+الـ… الـ… الـ… الـ«زوم»، الـ«تشات»، الـ«جروب تشات»
+
+19
+00:01:58,910 --> 00:02:03,670
+ولا الـ«هاي»، أنا بتبينش وإنه الـ«دسكتوب» تبعي كله
+
+20
+00:02:03,670 --> 00:02:09,590
+ظاهر عندكم في الصورة النقطة الأساسية إنه
+
+21
+00:02:09,590 --> 00:02:14,750
+الـ«بروتين» لما نشوفه في الحياة وفي الجسم بيقولوله
+
+22
+00:02:14,750 --> 00:02:19,410
+فيه أربع تركيباتأربع مستويات من التركيب، من
+
+23
+00:02:19,410 --> 00:02:26,190
+التعقيد الـ Primary Structure للبروتين هو عبارة عن
+
+24
+00:02:26,190 --> 00:02:31,550
+ترتيب الـ Amino Acids اللي بتشكل منها الـ
+
+25
+00:02:31,550 --> 00:02:37,070
+Polypeptide Chain اللي بتتشكل منها البروتين فلمّا
+
+26
+00:02:37,070 --> 00:02:42,470
+نتكلم إنه البروتين، يعني هندخل بعد شوية بالتفاصيل
+
+27
+00:02:42,980 --> 00:02:47,140
+بدّي الواحد يتخيله عشان يعرف يفهم أهمية الـ DNA
+
+28
+00:02:47,140 --> 00:02:54,040
+وليش ربنا حطوا فينا بهذه الطريقة فعنا بقول أربع
+
+29
+00:02:54,040 --> 00:03:03,160
+تركيبات لـ الـ اللي بده يرفع إيده الدكتور أحمد
+
+30
+00:03:03,160 --> 00:03:06,720
+معانا هو اللي بيخلي أنا بحب إنه حد يتكلم، بديش الـ
+
+31
+00:03:06,720 --> 00:03:11,560
+Chat هذا بودي إنه حد يتكلم حتى نفهم، يعني نشرح
+
+32
+00:03:11,560 --> 00:03:17,630
+الموضوعفلما نتكلم على تركيب الـ Protein نتكلم على
+
+33
+00:03:17,630 --> 00:03:24,030
+أربع خواص فيه أو أربع مستويات من التراكيب فيه لما
+
+34
+00:03:24,030 --> 00:03:28,070
+نقول بدا نصف الـ Primary Structure لأي Protein
+
+35
+00:03:28,070 --> 00:03:34,010
+بنقول إنه لازم نصف شو هو ترتيب الـ Amino Acids
+
+36
+00:03:34,010 --> 00:03:40,530
+اللي موجودة في الـ Polypeptide Chain فترتيب الـ
+
+37
+00:03:40,530 --> 00:03:44,330
+Amino Acidsهذا هو اللي يعتبر الـ Primary Structure
+
+38
+00:03:44,330 --> 00:03:51,750
+للـ Protein فإنها حوالي 20، 21 Amino Acid فبالتالي
+
+39
+00:03:51,750 --> 00:03:58,350
+لما نعد بواحد، اثنين، ثلاثة في الـ Polypeptide
+
+40
+00:03:58,350 --> 00:04:03,870
+Chainوبنقول إنه في أول أمينو أسد مثلًا «تريبتوفان»
+
+41
+00:04:03,870 --> 00:04:09,790
+«ألانين» مثلًا «أسبارتيت» كذا كذا الأمينو أسد اللي
+
+42
+00:04:09,790 --> 00:04:15,670
+بتعرفوها هدولة وصف الـ Primary Structure هو وصف
+
+43
+00:04:15,670 --> 00:04:20,110
+لإيش هي الأمينو أسد اللي بتكون منها البروتين الـ
+
+44
+00:04:20,110 --> 00:04:26,170
+Secondary Structure هو عبارة عن تركيب البروتين
+
+45
+00:04:26,170 --> 00:04:34,380
+الناتج عنالعلاقات والتفاعلات والتجاذبات بين الـ
+
+46
+00:04:34,380 --> 00:04:39,520
+Amino Acids جنب بعض فبينتج عن هذا التجاذب أنه فينا
+
+47
+00:04:39,520 --> 00:04:43,760
+نوعين من الـ Structures اللي بتكون المستوى الثاني
+
+48
+00:04:43,760 --> 00:04:48,000
+في تعقيد البروتين اللي هي بيسموه الـ Alpha Helix
+
+49
+00:04:48,000 --> 00:04:53,180
+أو الـ Beta Bleated Sheets يعني يا إما نتيجة
+
+50
+00:04:53,180 --> 00:04:58,070
+علاقاتالـ Side Chains تبعات الـ Amino Acids تبعات
+
+51
+00:04:58,070 --> 00:05:02,890
+الـ Primary Structure بيصير البروتين يلف على بعضه
+
+52
+00:05:02,890 --> 00:05:08,690
+إذا بتتخيلوا و بتشوفوا عندكم مثلا نفترض سليك
+
+53
+00:05:08,690 --> 00:05:13,730
+تليفون بين السماعة وجهاز التليفون بلولو بيصير
+
+54
+00:05:13,730 --> 00:05:19,610
+البروتين يتلولو بهذه الطريقة فوجود اللي بيسمونه
+
+55
+00:05:19,610 --> 00:05:24,170
+Alpha Helix أو Beta Bleated Sheets هدولة أنواع
+
+56
+00:05:24,500 --> 00:05:29,880
+أشكال التركيب الثانوي للبروتين يكون نتيجة علاقات
+
+57
+00:05:29,880 --> 00:05:33,420
+الـ Amino Acids مع بعض وبتكون الـ Amino Acids
+
+58
+00:05:33,420 --> 00:05:37,400
+هدولة جنب بعض لأنه حتى يلفب هذا الشكل القريب يكون
+
+59
+00:05:37,400 --> 00:05:42,680
+علاقات بين الـ Amino Acids مع بعض لما نكون نتكلم
+
+60
+00:05:42,680 --> 00:05:46,140
+عن الـ Tertiary Structure للبروتين زي الـ Globular
+
+61
+00:05:46,140 --> 00:05:53,130
+Structure إنه يكون على شكل مثلاًأبارعاً ثلاث إحبال
+
+62
+00:05:53,130 --> 00:05:59,030
+هيكلف على بعض أو على شكل كروي أو كده بيكون صار إنه
+
+63
+00:05:59,030 --> 00:06:06,750
+interaction between amino acid units on faraway
+
+64
+00:06:06,750 --> 00:06:13,090
+points on the amino acid polypeptide chain يعني
+
+65
+00:06:13,090 --> 00:06:18,250
+حتى يلف بهذا الشكل اللي يصير شكل كروي أو شكل بشكل
+
+66
+00:06:18,250 --> 00:06:20,530
+آخر ويكون نتيجة
+
+67
+00:06:23,460 --> 00:06:29,180
+التفاعلات بين الـ Amino Acids بعيدة عن بعضها في
+
+68
+00:06:29,180 --> 00:06:34,880
+الـ Primary Structure فهذه بتكون الـ Tertiary
+
+69
+00:06:34,880 --> 00:06:40,980
+Structure لأي بروتين ولمّا بعدين نتكلم على أن مثلا
+
+70
+00:06:40,980 --> 00:06:46,500
+الـ Hemoglobin بروتين عبارة عن حقيقة أربع
+
+71
+00:06:46,500 --> 00:06:52,950
+Polypeptidesأربع قطع، Two Alphas وTwo Betas كل
+
+72
+00:06:52,950 --> 00:06:56,910
+واحد منهم Alpha أو Beta هي عبارة عن بوليفيد بتاع
+
+73
+00:06:56,910 --> 00:07:03,190
+الـ Chain واحد معين وفي نصه فيه Hemomolecule الـ
+
+74
+00:07:03,190 --> 00:07:06,370
+Hemomolecule اللي فيه الحديد اللي بيمسك الـ Oxygen
+
+75
+00:07:06,370 --> 00:07:11,110
+فلما نتكلم على الـ Structure تبع الـ Total
+
+76
+00:07:11,110 --> 00:07:19,760
+Hemoglobin Protein بنقول إنه عبارة عن Fourوكل
+
+77
+00:07:19,760 --> 00:07:24,640
+واحدة منها Globular «هيمو» و «جلوبين» «جلوبين»
+
+78
+00:07:24,640 --> 00:07:30,500
+يعني كروي فالـ «هيمو» و «جلوبين» في أربع
+
+79
+00:07:30,500 --> 00:07:36,720
+Polypeptide Chains Two Alphas و Two Betas فالآن
+
+80
+00:07:36,720 --> 00:07:43,840
+يعني هذا كبروتين موجود في الجسم بتكون السر الأول
+
+81
+00:07:43,840 --> 00:07:47,570
+فيه في الـ Primary Structureاللي هو الـ Amino
+
+82
+00:07:47,570 --> 00:07:56,130
+Acids اللي بتكون منها وبعد ذلك، بتعقد الموضوع بالـ
+
+83
+00:07:56,130 --> 00:07:59,650
+Secondary Structure نتيجة الـ Alpha Helices والـ
+
+84
+00:07:59,650 --> 00:08:04,370
+Beta Pleated Sheets وبعدين بيصير أنها Tertiary
+
+85
+00:08:04,370 --> 00:08:10,070
+Structure نتيجة الحلقات
+
+86
+00:08:10,070 --> 00:08:15,480
+بين الـ Amino Acids البعد عن بعضوبعدين ندخل في الـ
+
+87
+00:08:15,480 --> 00:08:19,360
+Total Structure بالـ Quaternal Structure التركيب
+
+88
+00:08:19,360 --> 00:08:24,560
+الرباعي، الرابعي للبروتين فأي بروتين لما نيجي نصفه
+
+89
+00:08:24,560 --> 00:08:30,220
+نتكلم على أربع مستويات من الـ Structure فهو ياما
+
+90
+00:08:30,220 --> 00:08:35,960
+Primary وSecondary وTertiary وQuaternary الأمور
+
+91
+00:08:35,960 --> 00:08:38,340
+هيك واضحة، في حد عنده سؤال
+
+92
+00:08:41,490 --> 00:08:46,890
+دكتور أحمد، ماشي الحال، الشباب في حد .. ما .. ما
+
+93
+00:08:46,890 --> 00:08:51,050
+دكتور، مافي .. مافي .. مافي تحكي فيه جمانة رفعت
+
+94
+00:08:51,050 --> 00:08:56,350
+إيدها، تمام، بتخلي الجمانة تتكلم أو على أقل يعني
+
+95
+00:08:56,350 --> 00:09:02,190
+إثنين، ثلاثة تعطيهم سماح يتكلموا عشان نسمع يعني
+
+96
+00:09:02,190 --> 00:09:06,310
+يكونوا تفاعلوا بسرعة وشو اسمها؟ ان شاء الله، هنخلي
+
+97
+00:09:06,310 --> 00:09:13,390
+الدكتورة جمانة المستوى الرابع هو علاقاتإنه أكثر من
+
+98
+00:09:13,390 --> 00:09:19,670
+قطعة تدخل في تركيبه يعني، بدك تعتبر إنه زي «ليجو»…
+
+99
+00:09:19,670 --> 00:09:24,990
+ثوانية، جمانة، بس بعد إذنك، دكتور، اتفضل، كمل كأنه
+
+100
+00:09:24,990 --> 00:09:28,790
+زي قطعة «ليجو»، تعرفوها لعبة الأطفال اللي بتكون
+
+101
+00:09:28,790 --> 00:09:34,350
+أكثر من قطعة أحيانًا يكون أربع أو خمس أو أقل،
+
+102
+00:09:34,350 --> 00:09:41,430
+فنتين، تلاتة، individualPolypeptide chains يعني
+
+103
+00:09:41,430 --> 00:09:47,050
+عبارة عن تلاثة أو أربع قطع بروتينية بيشتركوا مع
+
+104
+00:09:47,050 --> 00:09:51,230
+بعض بيعطينا البروتين الأخير فزي الـ Hemoglobin الـ
+
+105
+00:09:51,230 --> 00:09:55,930
+Hemoglobin حقيقة هي أربع Polypeptide chains أربع
+
+106
+00:09:55,930 --> 00:10:01,310
+Globulins تنتين ألفة وتنتين بيتا كل واحد فيهم فيها
+
+107
+00:10:01,310 --> 00:10:05,710
+شغلة Hemoglobin راح ندخلها يعني Hem Group اللي هي
+
+108
+00:10:05,710 --> 00:10:16,710
+تمسك الـ Oxygen ف…ماشي أخت سهام آه الآن اللي سألة
+
+109
+00:10:16,710 --> 00:10:24,910
+سؤال رفعت إيدها تتكلم جمانة
+
+110
+00:10:24,910 --> 00:10:32,690
+أتكلم آه طيب الآن فالسر في كل التفاعلات البروتين
+
+111
+00:10:32,690 --> 00:10:39,540
+وخواص الحي المادة الحية هي حقيقةًفي ترتيب الـ
+
+112
+00:10:39,540 --> 00:10:46,700
+Amino Acids اللي موجودة في البروتين ماشي وحقيقة
+
+113
+00:10:46,700 --> 00:10:52,800
+يعني الواحد أنا بقول بده يعتبر هيك البروتين إبارة
+
+114
+00:10:52,800 --> 00:10:59,020
+عن إذا بدكم هيك عشان الواحد يستوعبها بقول يعتبر
+
+115
+00:10:59,020 --> 00:11:06,490
+إنها زي باللغة العربية نقور قصيدةالبردة، مدح
+
+116
+00:11:06,490 --> 00:11:12,690
+الرسول، قصيدة المعلقات، قصيدة إبارة عن مثلًا 150
+
+117
+00:11:12,690 --> 00:11:17,890
+بيت، بس بالأخير تركيب القصيدة في اللغة العربية
+
+118
+00:11:17,890 --> 00:11:23,830
+بالأخير هي أحرف، صحيح بتتكفكل من كلمات، بس الكلمات
+
+119
+00:11:23,830 --> 00:11:28,750
+بترجع للأخر للأحرف، وعنا في اللغة العربية 28 حرف،
+
+120
+00:11:30,460 --> 00:11:35,800
+البروتين لما نشوفه في واقع الحياة هو بيكون مثلًا
+
+121
+00:11:35,800 --> 00:11:43,680
+نعتبر قصيدة متكونة من كلمات نتيجة مكونة من أحرف
+
+122
+00:11:43,680 --> 00:11:50,460
+فبالأخير السر في القصيدة هي في ترتيب الأحرف تبعها
+
+123
+00:11:50,460 --> 00:12:02,330
+فالآن الـ DNA هو تمثيلمشفر بطريقة معينة حتى يضمن
+
+124
+00:12:02,330 --> 00:12:07,410
+كمادة وراثية للمعلومات اللي بالأخير بتعطينا الـ
+
+125
+00:12:07,410 --> 00:12:12,770
+Protein وبتعطينا القصيدة فهناك تشفير معين، رموز،
+
+126
+00:12:12,770 --> 00:12:19,930
+ترميز لكل حرف إنه شو اللي بيقابله من الـDNA حتى
+
+127
+00:12:19,930 --> 00:12:23,470
+يمكن عملية إنه نعمل
+
+128
+00:12:25,980 --> 00:12:32,820
+نعمل الـ «بروتينات» اللي احنا بحاجتها فالآن
+
+129
+00:12:32,820 --> 00:12:38,780
+لما ندرس المادة الوراثية اللي موجودة في الإنسان
+
+130
+00:12:38,780 --> 00:12:44,360
+وبتكون في كل خلايا الإنسان، الإنسان الواحد بشكل
+
+131
+00:12:44,360 --> 00:12:49,740
+رئيسي، بشكل يعني فيه هناك كأنه أكتر من نوع مادة
+
+132
+00:12:49,740 --> 00:12:53,340
+وراثية في جسم الواحد، راح نحكي عن دوار زي هيكبس
+
+133
+00:12:53,340 --> 00:12:56,640
+بشكل أساسي كل خلايا الإنسان لأنه بيبدأ من خلية
+
+134
+00:12:56,640 --> 00:13:00,780
+واحدة بيتم تلقيحها للبوايضة الملقحة بالحيوان
+
+135
+00:13:00,780 --> 00:13:05,120
+المنوي من الأب والأم، بالأخير الخلية الواحدة هذه
+
+136
+00:13:05,120 --> 00:13:09,440
+هي اللي بتنقسم كل الانقسامات المطلوبة وبنتج عنها
+
+137
+00:13:09,440 --> 00:13:14,180
+إنه بيصير اندي المظهر
+
+138
+00:13:14,180 --> 00:13:19,200
+اللي بنشوفه كذكر أو أمثة أو طفل أو كبير أو كده،
+
+139
+00:13:19,200 --> 00:13:27,930
+المادة الوراثية في الإنسانتقريبًا 97% موجودة في
+
+140
+00:13:27,930 --> 00:13:38,090
+النواة داخل الخليةفـ 97% من المادة الوراثية موجودة
+
+141
+00:13:38,090 --> 00:13:43,690
+في الـ Nuclear Chromosomes وهي حطيلكم صورة رسمية
+
+142
+00:13:43,690 --> 00:13:48,490
+أو صورة مش رسمية، يعني صورة الفحص اللي هو الـ
+
+143
+00:13:48,490 --> 00:13:52,530
+Karyotype اللي بنعمله وبكون في حالة الـ Cell
+
+144
+00:13:52,530 --> 00:13:56,910
+Division ممكن يكونوا مقابلين بعضه، بكون لهم ترتيب
+
+145
+00:13:56,910 --> 00:14:04,620
+معين وبنشوفههذا اللي هو بدرجة أساسية المادة
+
+146
+00:14:04,620 --> 00:14:09,040
+الوراثية تبع الإنسان في كل خلية حوالي 97%، يعني
+
+147
+00:14:09,040 --> 00:14:18,080
+تقريبًا 100% وبتكون لأنها لهم 23 زوج من
+
+148
+00:14:18,080 --> 00:14:22,460
+الـChromosomes فرح نقدر بعدين بتفصيل أكتر،
+
+149
+00:14:22,460 --> 00:14:30,970
+الـChromosomes هذه 22 زوجعبارة عن كروموزومات
+
+150
+00:14:30,970 --> 00:14:39,510
+أوتوزومال يعني جسمية اللي هي من 1 إلى 22 عبارة عن
+
+151
+00:14:39,510 --> 00:14:46,170
+تجميع للـ DNA بشكل معين وزوج أخر من الـ Six
+
+152
+00:14:46,170 --> 00:14:50,290
+chromosomes اللي هما الـ X والـ Y فهي اللي هي
+
+153
+00:14:50,290 --> 00:14:57,320
+التركيب تبعالـ Nuclear Chromosomes نسميهم المادة
+
+154
+00:14:57,320 --> 00:15:02,200
+الوراثية في النواة وتكون على شكل كروموزومات راح
+
+155
+00:15:02,200 --> 00:15:06,420
+ناخد تفصيلها وتركيبها وعلاقاتها بشكل أدق بعد شوية
+
+156
+00:15:06,420 --> 00:15:10,760
+تلاف بالمية طبعاً هدول الـ Nuclear Chromosomes
+
+157
+00:15:10,760 --> 00:15:14,680
+نصهم من الأب ونصهم من الأمالـ Mitochondrial
+
+158
+00:15:14,680 --> 00:15:20,220
+chromosomes بنسميهم قطعة صغيرة تبثل حوالي 3% من
+
+159
+00:15:20,220 --> 00:15:26,020
+الـ DNA في الخلايا الجسمانية بتكون من خلال الـ
+
+160
+00:15:26,020 --> 00:15:30,580
+mitochondria يعني الـ mitochondria اللي هي بتعرفوا
+
+161
+00:15:30,580 --> 00:15:34,640
+كلكم من المدارس إنها بنسميها أفران الطاقة في
+
+162
+00:15:34,640 --> 00:15:40,600
+الخليةبتكون هي المحل اللي بتتم فيها الـGlycolysis
+
+163
+00:15:40,600 --> 00:15:46,940
+والـRespiratory Chain والـCrip Cycle بحيث إنه يتم
+
+164
+00:15:46,940 --> 00:15:51,940
+هضم المواد زي الـGlucose بحيث يعطينا بالأخير ATP
+
+165
+00:15:51,940 --> 00:15:58,820
+وطاقة وبتكون الخلية بتتحرك من خلال الـATP اللي
+
+166
+00:15:58,820 --> 00:16:03,230
+بتحتاجه في عملية الطاقةفالـ Mitochondrial
+
+167
+00:16:03,230 --> 00:16:10,750
+chromosomes تمثل 3% من الـ DNA لاحظنا إن الـ
+
+168
+00:16:10,750 --> 00:16:15,370
+Proteins اللي هذا الـ DNA اللي موجود في الـ
+
+169
+00:16:15,370 --> 00:16:21,710
+Mitochondria مرتبط بالبروتينات اللي احنا بحاجتها
+
+170
+00:16:21,710 --> 00:16:27,570
+عشان نسوي الـ ATP عشان في الـ steps عشان نكوّن
+
+171
+00:16:27,570 --> 00:16:32,000
+المركبات الطاقة الـ ATPكل الأشياء اللي أنا عادة
+
+172
+00:16:32,000 --> 00:16:35,540
+بحتاجها أو غالبيتي الأشياء اللي أنا بحتاجها عشان
+
+173
+00:16:35,540 --> 00:16:40,080
+أطلع الـ ATP موجودة في الـ Mitochondrial DNA وهذه
+
+174
+00:16:40,080 --> 00:16:48,960
+تمثل 3% من الـ DNA بالنسبة
+
+175
+00:16:48,960 --> 00:16:56,940
+للـ ATP، آه بالنسبة لـ Mitochondrial Inheritance
+
+176
+00:16:56,940 --> 00:17:02,930
+للـ Mitochondrial DNAالوراثة تبعاتهم بتكون لأنه
+
+177
+00:17:02,930 --> 00:17:08,810
+الـ الـ «ميتوكندرية» بتنتقل من خلال الـ Boida فقط
+
+178
+00:17:08,810 --> 00:17:14,270
+الحيوان المنوي ما فيه «ميتوكندرية» فيه له أشياء
+
+179
+00:17:14,270 --> 00:17:20,090
+تراكيب ثانية بس مافي «ميتوكندرية» تشتغل في الـ
+
+180
+00:17:20,090 --> 00:17:25,110
+Fertilized egg فبالتالي الـ «ميتوكندرية» الـ DNA
+
+181
+00:17:25,110 --> 00:17:30,870
+انتقاله فقط عن طريق الأمعن طريق الأنثى ما في أي
+
+182
+00:17:30,870 --> 00:17:34,930
+انتقال من طريق الذكر زي الـ Nuclear Chromosomes
+
+183
+00:17:34,930 --> 00:17:39,370
+اللي فيها نص من الأب ونص من الأم فالـ
+
+184
+00:17:39,370 --> 00:17:44,590
+Mitochondrial DNA موجود في بعض الأمراض، راح ناخد
+
+185
+00:17:44,590 --> 00:17:48,670
+بعض الأمثل عليها بتكون نتيجة Mitochondrial
+
+186
+00:17:48,670 --> 00:17:53,410
+Chromosome Anomalies وبتكون فيها مشاكل لهذا الجرم
+
+187
+00:17:53,410 --> 00:17:56,390
+فالآن
+
+188
+00:17:57,320 --> 00:18:05,060
+يعني حتى إن شفّر الأحرف اللي هي تبعت قصيدة الـ
+
+189
+00:18:05,060 --> 00:18:12,040
+Protein ماشي مثلا، يعني زي إذا بدأت تعتبر مثلا
+
+190
+00:18:12,040 --> 00:18:16,080
+القفة نفكي من ذكرا حبيبا ومنزلي بسقط اللي هو بين
+
+191
+00:18:16,080 --> 00:18:22,320
+الدخولي فحملي عند معلقة تمرو القيس القاف في قفة
+
+192
+00:18:22,320 --> 00:18:30,160
+ماشي هي Amino Acid بسحتى أشفره بالـ DNA بدي أكون
+
+193
+00:18:30,160 --> 00:18:36,780
+عندي ثلاثة من الـ Nucleotides تبع الـ DNA وبصير
+
+194
+00:18:36,780 --> 00:18:44,180
+أنا أقرأ الـ DNA بهذا الشكل فالقراءته
+
+195
+00:18:44,180 --> 00:18:49,120
+بنسميها اللي هي الـ Human Genome Sequence اللي هو
+
+196
+00:18:49,120 --> 00:18:53,280
+إنه أنا أقرأ شو الأحرف أو بلاش أسميه أحرف شو
+
+197
+00:18:53,280 --> 00:19:01,030
+التشفير تبع الأحرف تبعالبروتين اللي يعني بيكون
+
+198
+00:19:01,030 --> 00:19:05,390
+بيمثل البروتين اللي هو بيمثل الكائن الحي اللي هو
+
+199
+00:19:05,390 --> 00:19:11,930
+الإنسان فأرجو أن تكون تركيب يعني أو كيف تجهيز
+
+200
+00:19:11,930 --> 00:19:17,510
+المادة اللازمة لإنتاج البروتين اللي هم اللي بالأخر
+
+201
+00:19:17,510 --> 00:19:21,140
+بنسميهم فيه Nuclear Chromosomesبيكونوا بطريقة
+
+202
+00:19:21,140 --> 00:19:25,500
+معينة نورثهم من الأب والأم جزء قليل من الـ
+
+203
+00:19:25,500 --> 00:19:28,580
+Mitochondrial chromosomes ونتخذهم من الأم فقط
+
+204
+00:19:28,580 --> 00:19:34,840
+وبتكون حوالي 3% وهسة راح ندخل أكتر تفاصيل كيف هذا
+
+205
+00:19:34,840 --> 00:19:41,560
+الأمر بتتم في أسئلة؟ في إشي مش واضح؟ في حد عنده
+
+206
+00:19:41,560 --> 00:19:42,160
+سؤال؟
+
+207
+00:19:48,450 --> 00:19:56,390
+ماشي اسأله إذا الواحد بيظل يعني بتظلكم ساكتين مش
+
+208
+00:19:56,390 --> 00:20:01,250
+عارف نعرف الآن
+
+209
+00:20:01,250 --> 00:20:12,630
+بالنسبة لتركيب الـ DNA هو من أهم الأشياءومن يعني
+
+210
+00:20:12,630 --> 00:20:17,490
+لما اكتشفوه وافتشفوا كيف بالداخل دكتور في سؤال
+
+211
+00:20:17,490 --> 00:20:24,150
+بيقول يعني في نور ما فهم شو دخل الـ «ميتوكندرية»
+
+212
+00:20:24,150 --> 00:20:31,630
+بالبروتين بالأم أعتقد غصده بالـ «ماتر» يعني ده
+
+213
+00:20:31,630 --> 00:20:38,350
+بيطهم وخليه يسأل الـ «ميتوكندرية»
+
+214
+00:20:39,680 --> 00:20:44,860
+انتقالها عبارة عن إنها موجودة في البويضة طبعاً
+
+215
+00:20:44,860 --> 00:20:50,100
+يعني هاي … يعني الـMitochondria هي فرن الطاقة اللي
+
+216
+00:20:50,100 --> 00:20:55,460
+لما تيجي تاخدها كتدريب يعني أنتوا بتخلونا نشرح مش
+
+217
+00:20:55,460 --> 00:20:59,120
+غلط الواحد يتعرف على أشياء تانية الـMitochondria
+
+218
+00:20:59,120 --> 00:21:06,870
+في الخلية تعتبر أحياناً زي جسم غريبزي بكتيريا
+
+219
+00:21:06,870 --> 00:21:12,890
+صغيرة حقيقةً هي بكتيريا صغيرة موجودة جوا الخلية
+
+220
+00:21:12,890 --> 00:21:18,350
+وبتكون عشان يعني هيكذا بتشوفوا بالنسبة لصورتها الـ
+
+221
+00:21:18,350 --> 00:21:22,270
+Cell Membrane تبع الخلية واحد بس الـ Mitochondria
+
+222
+00:21:22,270 --> 00:21:26,130
+is الـ Wall تبع الـ Mitochondria Double يعني
+
+223
+00:21:26,130 --> 00:21:30,770
+بيعتبروا أنه في إشي جوا إشي فالـ Mitochondria
+
+224
+00:21:30,770 --> 00:21:40,750
+جواها في DNA البروتيناتاللي بتنتج عن تشغيل وتفعيل
+
+225
+00:21:40,750 --> 00:21:46,110
+الـ «DNA» بحيث يعطينا بروتين هو راح يكون إنه
+
+226
+00:21:46,110 --> 00:21:50,970
+يعطينا البروتينات اللازمة لعملية إنتاج الطاقة
+
+227
+00:21:50,970 --> 00:21:55,030
+وإنتاج الـ «DNA» ما هو الـ «ميتوكندرية» وظيفتها
+
+228
+00:21:55,030 --> 00:22:01,070
+إنها تطلع الـ ATP اللي التفاعلات الكيموية والحركة
+
+229
+00:22:01,070 --> 00:22:07,020
+في الخلية وغيرها، بدها طاقة، فبتكون من الـالـ ATP
+
+230
+00:22:07,020 --> 00:22:11,280
+اللي بنتج من الميتوكندرية نتيجة تفاعلات تحتاج
+
+231
+00:22:11,280 --> 00:22:15,700
+بروتينات الـ DNA لهذه البروتينات في الميتوكندرية
+
+232
+00:22:15,700 --> 00:22:21,800
+وهذا يتم نقله من خلال البويضة فقط يعني الـ sperm
+
+233
+00:22:21,800 --> 00:22:26,420
+من الأب ماهي له دخلة عشان هيك لما تدرس الـ
+
+234
+00:22:26,420 --> 00:22:29,180
+mitochondrial inheritance والـ mitochondrial
+
+235
+00:22:29,180 --> 00:22:36,450
+diseases بتكون انتقالها عن طريق الأمة واضح؟في لسة
+
+236
+00:22:36,450 --> 00:22:40,790
+سؤال، اسألني أنت يا أحمد إذا في حد عنده شيء مش
+
+237
+00:22:40,790 --> 00:22:45,470
+واضح، أه
+
+238
+00:22:45,470 --> 00:22:49,730
+فيه بيعلق يعني، بيسأل، بيعقب على السؤال، بيقول
+
+239
+00:22:49,730 --> 00:22:55,530
+يعني كل الموضوع إنه العمليات بتحتاج ATP، طبعاً كل
+
+240
+00:22:55,530 --> 00:23:00,870
+كثير من عمليات الكيموية والحركية وغيرها، فللخلايا
+
+241
+00:23:00,870 --> 00:23:06,060
+بدها طاقة،الباقة بتيجي من الـ ATP الـ ATP بنتجه
+
+242
+00:23:06,060 --> 00:23:11,840
+تفاعلات كيموية بدها أنزيمات وبروتينات نتيجة يعني
+
+243
+00:23:11,840 --> 00:23:16,780
+بتكون في الـ mitochondria وهدولة الـ الـ DNA
+
+244
+00:23:16,780 --> 00:23:21,700
+المسؤول عنها موجود جوا الـ mitochondria بيمثل 3%
+
+245
+00:23:21,700 --> 00:23:27,680
+من الـ DNA تبع الخلية وهذا يتم نقله من خلال الأم
+
+246
+00:23:27,680 --> 00:23:34,000
+فقط الأب ما إله دخلفاهم عليك كيف؟ وهذه حتى إذا
+
+247
+00:23:34,000 --> 00:23:38,640
+واحد قرأ دراسة قبل مدة إنه بيرجعوا البشر كلهم لـ7
+
+248
+00:23:38,640 --> 00:23:44,740
+أمهات لأنه فيه variation بشكل معين وإنه بتكون
+
+249
+00:23:44,740 --> 00:23:48,540
+لدراسة الـMitochondrial DNA والـMitochondrial
+
+250
+00:23:48,540 --> 00:23:52,940
+Chromosomes فهدولة موجودين وهدولة أحيانًا بسببوا
+
+251
+00:23:52,940 --> 00:23:58,100
+أمراض حتى لو ما كان في الـNucleus اللي هي الجزء
+
+252
+00:23:58,100 --> 00:24:03,100
+الأكبر من الـDNA فيهابس دايماً لما نقول gene هو
+
+253
+00:24:03,100 --> 00:24:09,040
+شيء بالمادة الورافية يعني يمكن توريثه ويمكن اللي
+
+254
+00:24:09,040 --> 00:24:14,280
+أخدناه فضية انقسامه وبالتالي بتعطينا بدل نسخة
+
+255
+00:24:14,280 --> 00:24:20,940
+واحدة نسختين ويتكاثر بشكل يحفظ المادة الورافية
+
+256
+00:24:20,940 --> 00:24:24,940
+اللي بتعطينا شكل الـ protein اللي راح يطلع بالأخير
+
+257
+00:24:24,940 --> 00:24:26,900
+واضح؟
+
+258
+00:24:32,000 --> 00:24:37,120
+هي حد عنده سؤال؟
+
+259
+00:24:37,120 --> 00:24:43,260
+طيب التركيب،
+
+260
+00:24:43,260 --> 00:24:50,860
+خلّينا نرجع لهذه شوية تركيب الـ DNA وهذا في سنة
+
+261
+00:24:50,860 --> 00:24:56,240
+الـ 1954 وبعدين أخذوا عليه جهازة Nobel عالمين
+
+262
+00:24:56,240 --> 00:25:02,130
+اسمهم Watson وCreekأثبتوا أو من خلال دراستهم
+
+263
+00:25:02,130 --> 00:25:07,990
+لتقنية الـ X-Ray Crystallography أيشي طريقة بندرس
+
+264
+00:25:07,990 --> 00:25:15,650
+فيها المركبات وتركيبة كيماوية أنه بنشع عليها X
+
+265
+00:25:15,650 --> 00:25:21,210
+-Rays وبنشوف في الفيلم كيف تركيبه وكذا أثبتوا أن
+
+266
+00:25:21,210 --> 00:25:28,080
+الـ DNA عبارة عن سلم حلزوني بهذا الشكل السلمالعادي
+
+267
+00:25:28,080 --> 00:25:34,840
+بتلاقي يعني قصتين طوال وبينهم اقصار الـ «steps»
+
+268
+00:25:34,840 --> 00:25:41,620
+اللي بتطلع عليهم فبالنسبة للـ «DNA» السلم هذا
+
+269
+00:25:41,620 --> 00:25:47,820
+لولبي يعني بيقعد يلف على بعضه فإذا أنت بتشوفه
+
+270
+00:25:47,820 --> 00:25:54,380
+تركيبيعني هذا هي شكله اللي هو بنسميه سلة ملولة
+
+271
+00:25:54,380 --> 00:26:01,780
+بالـ Double Helix Ladder يعني هذا شكله الدورة
+
+272
+00:26:01,780 --> 00:26:07,100
+الكاملة منه زي هذا الشكل أربعة و تلاتين Angstrom
+
+273
+00:26:07,100 --> 00:26:14,480
+اللي هو كـ Size وبين عشر سطبات
+
+274
+00:26:14,480 --> 00:26:20,640
+أو عشرالمكان اللي بتحط إجرك عليه في السلم، العتبات
+
+275
+00:26:20,640 --> 00:26:25,120
+تبعته اللي هي طولها بين الواحد والثانية، ثلاث
+
+276
+00:26:25,120 --> 00:26:28,700
+وأربعة من عشرة أنجستروك لما تيجي تاخد تركيب هذا
+
+277
+00:26:28,700 --> 00:26:35,120
+الأمر بتلاقي أول شيء أنه في اللي هي الخضرة الفاتحة
+
+278
+00:26:35,120 --> 00:26:43,990
+هذه اللي هو رايبو رايبوزو اللي هوالريبوز اللي هو
+
+279
+00:26:43,990 --> 00:26:50,850
+السكر الخماسي اللي هو هذا الريبوز آسف بالـ DNA
+
+280
+00:26:50,850 --> 00:26:55,870
+ديوكسي ريبوز لأن الـ RNA هو اللي فيه الريبوز بس
+
+281
+00:26:55,870 --> 00:27:01,130
+الريبوز هو سكر خماسي
+
+282
+00:27:01,130 --> 00:27:06,010
+يعني فيه خمس درّات كربون وفيه من طرف تاني فوسفات
+
+283
+00:27:09,390 --> 00:27:15,730
+الخشب الطويلة تبعت السلم عبارة عن هيك فوسفات دوكسي
+
+284
+00:27:15,730 --> 00:27:19,090
+رايبوس، فوسفات دوكسي رايبوس، فوسفات دوكسي رايبوس
+
+285
+00:27:19,090 --> 00:27:28,310
+بالترتيب هذا، هذا أشي ثابت، ماشي، بالنص بينهم فيه
+
+286
+00:27:28,310 --> 00:27:34,100
+قواعد نيتروجينية، nitrogen basesففيه عندنا الـ…
+
+287
+00:27:34,100 --> 00:27:40,860
+الـ… يعني هنا هذه التركيب الـ… الـ… أقولها، هذه
+
+288
+00:27:40,860 --> 00:27:46,020
+مجموعة الفوسفات وهذه الـRibose وهنا بشبك فيه
+
+289
+00:27:46,020 --> 00:27:50,280
+الـBase رقم واحد بعدين بيجي فوسفات، بيجي Ribose،
+
+290
+00:27:50,280 --> 00:27:54,160
+بيجي الـBase رقم اثنين فوسفات، Ribose، الـBase رقم
+
+291
+00:27:54,160 --> 00:28:01,830
+ثلاثة تيجي بهذا الترتيب الـ… بالنسبة لـ…لما ناخد،
+
+292
+00:28:01,830 --> 00:28:10,810
+نقيص على تركيبة الـ «ريبوز» إنه إذا بتاخدوا
+
+293
+00:28:10,810 --> 00:28:17,310
+بالكيميا الحيوية، بتكون إنك أنت بتقدرالشكل الريبوز
+
+294
+00:28:17,310 --> 00:28:26,690
+هذا جاي خماسي بس بنحسب بما أنه هنا الأكسجينة الـ
+
+295
+00:28:26,690 --> 00:28:31,870
+Deoxyribose بيكون الريبوز فيه أكتر من هيك بس
+
+296
+00:28:31,870 --> 00:28:37,730
+الأكسجينة بنحسب عليها فبتقدروا أن هذا الكربون
+
+297
+00:28:37,730 --> 00:28:41,210
+الأولى وهذه الكربون الثانية وهذه الثالثة وهذه
+
+298
+00:28:41,210 --> 00:28:47,680
+الرابعة وهذه الخمسة فالـ Phosphateبتشبك على من جهة
+
+299
+00:28:47,680 --> 00:28:54,020
+في رقم خمسة ومن جهة في رقم ثلاثة فلما نيجي نتكلم
+
+300
+00:28:54,020 --> 00:29:02,780
+كيف شكل ترتيب العصاطين القشبيات بكونوا عكس بعض
+
+301
+00:29:02,780 --> 00:29:09,340
+بحيث إنه في عصاية من جهة تبدأ بالـ ribosomes تشبك
+
+302
+00:29:09,340 --> 00:29:15,820
+عليها من جهة رقم خمسة بيسموها الـ5'Nبيظل ماشي لحد
+
+303
+00:29:15,820 --> 00:29:20,140
+الـ Third Prime إنه بالنسبة للـ Ladder الثاني
+
+304
+00:29:20,140 --> 00:29:24,940
+بيكون ماشي بالعكس بدأ من تحت بالـ Five وبيطلع من
+
+305
+00:29:24,940 --> 00:29:29,360
+فوق على ال Third أو على ال Three Prime يعني هدولة
+
+306
+00:29:29,360 --> 00:29:36,620
+في تفاصيل التركيب الكيماوي للـ DNA هدولة العصاطين
+
+307
+00:29:36,620 --> 00:29:41,960
+أو الخشبتين الطوال بيلفوا على بعض بهذا الشكل
+
+308
+00:29:42,540 --> 00:29:51,040
+وبكونوا يعني بكونوا ماشيين يعني اتجاههم من خمس
+
+309
+00:29:51,040 --> 00:29:55,540
+لثلاث ومن خمس لثلاث حتى يظبط ان يكون هذا الشكل
+
+310
+00:29:55,540 --> 00:30:00,140
+بهذه الطريقة واللي بمسكهم بالنص اللي هي العطبات
+
+311
+00:30:00,140 --> 00:30:06,730
+اللي بقدر أجر عليها وانا طالع بكون في عنديزوج من
+
+312
+00:30:06,730 --> 00:30:12,470
+الأحماض الـ Amino الـ Nitrogenous Bases القواعد
+
+313
+00:30:12,470 --> 00:30:17,670
+النيتروجينية فالقواعد النيتروجينية بنقسمهم إشي
+
+314
+00:30:17,670 --> 00:30:21,790
+اسمه Purines قواعد نيتروجينية هي فيها نيتروجين
+
+315
+00:30:21,790 --> 00:30:26,570
+وCarbon بهذا الشكل فالـPurines اللي هي الأكبر فيها
+
+316
+00:30:26,570 --> 00:30:30,650
+Two Rings Like This منها الأدينين ومنها الإيجوانين
+
+317
+00:30:30,650 --> 00:30:35,650
+وهذا المفروض أخد Two بالـBiochemistryفالـ Purines
+
+318
+00:30:35,650 --> 00:30:39,910
+اللي هم الأكبر والـ Pyrimidines اللي هم الأصغر
+
+319
+00:30:39,910 --> 00:30:45,930
+اللي هم الثيامين والـ Cytosine فالـ DNA بيكون هدول
+
+320
+00:30:45,930 --> 00:30:51,570
+الأربع المشتركين كل step نحط أجرنا عليها وإحنا
+
+321
+00:30:51,570 --> 00:30:57,510
+طالعين على السلم بتكون واحد Purine مع واحد
+
+322
+00:30:57,510 --> 00:31:02,490
+Pyrimidine بس الأدنين مع الثيامين والجوانين مع الـ
+
+323
+00:31:02,490 --> 00:31:09,380
+Cytosine يعنيدايماً على الجهة هذه، اندي واحدة من
+
+324
+00:31:09,380 --> 00:31:12,860
+أربع خيارات ممكن تكون عندي ممكن تكون Guanine،
+
+325
+00:31:12,860 --> 00:31:18,960
+Cytosine، Adenosine، Adenine أو Guanine مرة ثانية،
+
+326
+00:31:18,960 --> 00:31:24,240
+فكل واحد من هذا لازم يشبك مع واحد من النوع التاني،
+
+327
+00:31:24,240 --> 00:31:28,660
+فهنا كانت Guanine شبكة high مع Cytosine، هنا
+
+328
+00:31:28,660 --> 00:31:34,090
+Cytosine مع Guanine، هنا Adenine مع الثامن،فدول
+
+329
+00:31:34,090 --> 00:31:37,070
+الأدنين والثامين زي ما انتوا شايفين بيكون two
+
+330
+00:31:37,070 --> 00:31:45,180
+bonds بين الإيجوانين والسايتزين تلاتي bondsFossile
+
+331
+00:31:45,180 --> 00:31:49,380
+bond يعني Hydrogen bond شوية نوع عامة ضعيف كثير مش
+
+332
+00:31:49,380 --> 00:31:53,660
+قوية كثير، يعني مش Covalent bond مش Ionic bond،
+
+333
+00:31:53,660 --> 00:31:58,460
+يعني إشي قوي كثير، لأ عبارة عن شيء ممكن أنا أفكه و
+
+334
+00:31:58,460 --> 00:32:04,520
+أركبه، بس فيه قوة وانتصاق وممكن يشبك مع بعض،
+
+335
+00:32:04,520 --> 00:32:12,300
+فبالنسبة لتركيب الـ DNA، هذا تركيبه، بالنسبة
+
+336
+00:32:12,300 --> 00:32:21,740
+لترتيباللي بيعطينا الشفرة عشان نعرف نطلع البروتين
+
+337
+00:32:21,740 --> 00:32:28,020
+اللي كويس هو ترتيب هذه الـ… الـNitrogenous Bases
+
+338
+00:32:28,020 --> 00:32:32,280
+هذا الترتيب هو اللي بالأخير راح يكون مسئول عن
+
+339
+00:32:32,280 --> 00:32:38,280
+البروتين اللي راح يطلع فطبعاً
+
+340
+00:32:38,280 --> 00:32:43,690
+يعني وجود هذا التركيب، سبحان الله يعنيعجيب، ويعني
+
+341
+00:32:43,690 --> 00:32:47,250
+فعلاً اللي اكتشفوا وفسروا الظواهر اللي إحنا
+
+342
+00:32:47,250 --> 00:32:51,950
+بنشوفها كيف الخلية بتنقسم، كيف ممكن المادة
+
+343
+00:32:51,950 --> 00:32:56,470
+الوراثية تورّف كم ممكن أن يحافظ عليها، كيف يتم
+
+344
+00:32:56,470 --> 00:33:02,570
+نسخها، كيف يتم التعامل معها أخد جائزة نوبل، وهذه
+
+345
+00:33:02,570 --> 00:33:06,030
+يعني بتفسر كثير من الظواهر وهذا الآن اللي إحنا
+
+346
+00:33:06,030 --> 00:33:10,790
+بنعتبره في علم الوراثة في حد عنده سؤال، في إيش مش
+
+347
+00:33:10,790 --> 00:33:11,230
+واضح
+
+348
+00:33:17,730 --> 00:33:23,910
+دكتور أحمد غيره أو أي حد عنده أي سؤال؟ لا دكتور
+
+349
+00:33:23,910 --> 00:33:28,030
+اتوكل على الله غالبا مافي أسئلة في الشاشة طيب،
+
+350
+00:33:28,030 --> 00:33:34,550
+الآن دكتور في سؤال من دكتورة سيهام تسأل شو اسم
+
+351
+00:33:34,550 --> 00:33:40,630
+الأشعة؟ هذا تقنية أو تقنية في دراسة اللي اشتغل
+
+352
+00:33:40,630 --> 00:33:50,030
+عليها واتسون وكريج أه أه أه بحكيلكمن الطرق اللي
+
+353
+00:33:50,030 --> 00:33:55,350
+قديمة في دراسة التركيب الكيماوي للمركبات اللي هي
+
+354
+00:33:55,350 --> 00:34:04,210
+إنه بتخلي المادة على شكل بلوراتشايف علي؟ يعني أنت
+
+355
+00:34:04,210 --> 00:34:13,390
+بتجيب سواء DNA، سخرة، بروتين، دهول، أي شيء بتبردها
+
+356
+00:34:13,390 --> 00:34:19,890
+بحيث تصبح على شكل بلورة يعني إنها ترتب حالها بشكل
+
+357
+00:34:19,890 --> 00:34:23,190
+منتظم،
+
+358
+00:34:23,190 --> 00:34:28,830
+مش يعني فالته فلما ترتبها بشكل منتظم، بعدين
+
+359
+00:34:28,830 --> 00:34:36,250
+بتعرضها لأشعة Xلما نتيجي على زي أشعة العظام لما
+
+360
+00:34:36,250 --> 00:34:41,670
+نتعرضها لهذه الأشعة تتفرج الجهة الثانية على كيف
+
+361
+00:34:41,670 --> 00:34:47,750
+صورتها من خلال الأشعة على فيلم الأشعة بتقول تقدر
+
+362
+00:34:47,750 --> 00:34:52,010
+تستنتج كيف كان تركيبها فهذه التقنية اسمها X-Ray
+
+363
+00:34:52,010 --> 00:34:58,280
+Crystallography يعني Crystal بلورةوGeography يعني
+
+364
+00:34:58,280 --> 00:35:04,240
+شو اسمه؟ عبارة عن تصوير التصوير البلوري عن طريق
+
+365
+00:35:04,240 --> 00:35:09,880
+أشعة X هيك اللي كان يستخدموه فمن خلالها الأبعاد
+
+366
+00:35:09,880 --> 00:35:14,400
+اللي هي بنحكيها الـ «أنغستروم» اللي هي إذا تتفرج
+
+367
+00:35:14,400 --> 00:35:18,940
+هنا إنه عشرين أنغستروم وهي أربعة وثلاثين أنغستروم
+
+368
+00:35:18,940 --> 00:35:24,680
+وبين واحدة واحدة 3.4 وفي عشرة في كل لولب، هي من
+
+369
+00:35:24,680 --> 00:35:29,570
+خلالطريقة الدراسة هذه استطعنا نقرأ شو تركيبها
+
+370
+00:35:29,570 --> 00:35:34,910
+واضحة؟ فهي X-Ray Crystography يعني التصوير البلوري
+
+371
+00:35:34,910 --> 00:35:42,730
+بأشعة X هذه التقنية وهكي عرفوا تركيب الـDNA في
+
+372
+00:35:42,730 --> 00:35:52,930
+أسئلة ثانية؟ إيش يا باي سلان؟ باي لسان؟ إيش دكتور
+
+373
+00:35:52,930 --> 00:35:57,900
+أحمد؟ خليها تتكلم أوأسمع منكم إذا في أسئلة ثانية
+
+374
+00:35:57,900 --> 00:36:04,460
+في
+
+375
+00:36:04,460 --> 00:36:11,100
+أسئلة؟ اتفضل يا «بالي لسان» إذا كان في سؤال خلاص،
+
+376
+00:36:11,100 --> 00:36:17,000
+تمام، بالخطأ، مش مشكلة مش مشكلة بالنسبة ل… الآن
+
+377
+00:36:17,000 --> 00:36:23,440
+يعني حكينا يعني ليش الأمر ربنا حطه فينا بهذا الشكل
+
+378
+00:36:23,440 --> 00:36:31,790
+بالنسبة للـDNAإن انت بتقدر تستنسخ بشكل دقيق وثابت
+
+379
+00:36:31,790 --> 00:36:41,590
+ومحدد تماماً قضية إنه نسخة واحدة من الـ DNA زي
+
+380
+00:36:41,590 --> 00:36:46,150
+القطعة اللي فوق عندما تحتاج أو في مرحلة معينة
+
+381
+00:36:46,150 --> 00:36:53,790
+بتفرط الخشبتين تبع السلة من اللولة بعن بعضوتقدر
+
+382
+00:36:53,790 --> 00:37:02,030
+تعيد بناءهم كامل مكمّل زي ما كان في الأساس من خلال
+
+383
+00:37:02,030 --> 00:37:07,750
+الاحتفاظ بنفس العلاقات بين القواعد النيتروجينية
+
+384
+00:37:07,750 --> 00:37:16,190
+الـA قبالها الـT والـC قبالها الـG وكل يعني
+
+385
+00:37:16,190 --> 00:37:26,770
+backbone أو كل خط من هدولة ترتيبالـ… الأحماض أو
+
+386
+00:37:26,770 --> 00:37:33,010
+الترتيب القواعد النيتروجيني هنا يحفظ تمامًا والـ…
+
+387
+00:37:33,010 --> 00:37:39,230
+والإيش الناقص يتمم بالترتيب كامل بحيث بنسبة عالية
+
+388
+00:37:39,230 --> 00:37:46,990
+جدًا جدًا بتم استنساح الـDNA بحيث يكون بشكل كامل،
+
+389
+00:37:46,990 --> 00:37:56,070
+بشكل متطابق تمامًافيعني هذه سر في قضية حفظ
+
+390
+00:37:56,070 --> 00:38:02,750
+المعلومات وحفظ الشفرة الوراثية لكل واحد مننا من
+
+391
+00:38:02,750 --> 00:38:08,430
+خلال أنه لما تحتاج تقسم وتضاعف من المادة الوراثية
+
+392
+00:38:08,430 --> 00:38:14,220
+بتقدر تضاعفها وتكون تماما مثل الأبمثل الأصل، يعني
+
+393
+00:38:14,220 --> 00:38:17,780
+مثل ما كانت سابقًا فبدل ما يكون عندك نسقة واحدة
+
+394
+00:38:17,780 --> 00:38:27,140
+بتصير عندك نسقتين تمامًا زي بعض، فيها أسئلة واضحة؟
+
+395
+00:38:27,140 --> 00:38:36,840
+الآن اللي لما إذا بتتخيلوا طبعًا عدد القواعد
+
+396
+00:38:36,840 --> 00:38:41,080
+النيتروجينية هدولة اللي هي بدنا نسميهم الأحرف في
+
+397
+00:38:41,080 --> 00:38:46,240
+الـDNAتقريبًا في الخلية الوحدة، في جسم الإنسان كله
+
+398
+00:38:46,240 --> 00:38:53,000
+هيك مع بعضه، ثلاث بلايين حرف، ثلاث بلايين
+
+399
+00:38:53,000 --> 00:38:58,580
+نيكليوتايد، طبعًا هذا أدد يعني ما واحد ييجي يتخيله
+
+400
+00:38:58,580 --> 00:39:03,320
+أدد كبير كثير، أنتوا آخر، أنتوا معاكم، اللي ورا
+
+401
+00:39:03,320 --> 00:39:10,350
+آخر جزء من هنا واضح ولا صورتنا جاي عليها؟أنت بتشوف
+
+402
+00:39:10,350 --> 00:39:15,290
+نفسك أنه بتطلع على الـscreen تبعي ولا ..؟ صح، صح،
+
+403
+00:39:15,290 --> 00:39:20,070
+لأ يا دكتور، واضحة بالنسبة للكل، يعني غالبا ما
+
+404
+00:39:20,070 --> 00:39:25,170
+بتكون نفس الـscreen الموجود عندنا طيب، تمام، لما
+
+405
+00:39:25,170 --> 00:39:33,840
+نيجي نتكلم على أنه عبارة عن nucleotidesماشي
+
+406
+00:39:33,840 --> 00:39:39,600
+تقريبًا هي ثلاث بلايين يعني ثلاثة في عشرة أس تسعة
+
+407
+00:39:39,600 --> 00:39:44,600
+لما تيجيوا تتخيلوا إذا أنتموا بتتذكروا أيام زمان
+
+408
+00:39:44,600 --> 00:39:51,820
+يمكن ماحدش منكم لحق هذا الموضوع كان زمان يكون
+
+409
+00:39:51,820 --> 00:39:58,740
+عندنا بيسموه اللي هو دليل الهاتف دليل الهاتف في أي
+
+410
+00:39:58,740 --> 00:40:05,290
+منطقة في العالمكان يبقى كتاب هيك سميك كثير ويكون
+
+411
+00:40:05,290 --> 00:40:10,070
+الخط صغير ويحطوا أسماء الناس ورقام تليفوناتهم
+
+412
+00:40:10,070 --> 00:40:13,650
+الأرضية يعني قبل التقنية الحالية والأشياء الآن
+
+413
+00:40:13,650 --> 00:40:21,830
+فدليل الهاتف يعني بيكون الخط صغير والصفحة فيها
+
+414
+00:40:21,830 --> 00:40:27,550
+مثلا تقريبًا خمس كولوك يعني خمس أعمدة من المادة
+
+415
+00:40:27,550 --> 00:40:33,870
+والورق خفيف كثيرفقدروا إذا انت بدك تكتب المادة
+
+416
+00:40:33,870 --> 00:40:37,690
+الوراثية تبع إنسان اللي هي موجودة الـ 9 ملايين
+
+417
+00:40:37,690 --> 00:40:43,740
+نيكليوتايد هذه فانت بتحتاج تقريبًامالة إنك تصفق
+
+418
+00:40:43,740 --> 00:40:48,400
+بعض من دلائل الهاتف ما هو بارتفاع اللي هي الـ
+
+419
+00:40:48,400 --> 00:40:53,300
+Empire State Building اللي هي كانت لحظة كبيرة يعني
+
+420
+00:40:53,300 --> 00:40:57,400
+أعلى برج في العالم وأعلى إشي يعني الآن بدك تقول
+
+421
+00:40:57,400 --> 00:41:02,180
+تقريبًا أقل شوية من برج خليفة في دبي ولا كده ولا
+
+422
+00:41:02,180 --> 00:41:09,110
+هيك فيعني هناك 9 بلايين Nucleotideاللي هي
+
+423
+00:41:09,110 --> 00:41:13,570
+الـNucleotide هو الإسم على القطعة المشتركة من
+
+424
+00:41:13,570 --> 00:41:17,410
+الـDioxyribose
+
+425
+00:41:17,410 --> 00:41:21,870
+مع الفوسفاب مع الـNitrogenous Base الثلاثة دولة
+
+426
+00:41:21,870 --> 00:41:26,120
+بنسميهم Nucleotide بيجوا هي كقطعة واحدةفالـ
+
+427
+00:41:26,120 --> 00:41:32,540
+Nucleotide هذا طبعاً بنسميه عادةً حسب الـ حسب شو
+
+428
+00:41:32,540 --> 00:41:42,000
+الـ Nitrogen Base فلما نيجي يعني نشوف الـ الـ
+
+429
+00:41:42,000 --> 00:41:48,760
+Double Helix هذا ماشي لو بدي أفرضه و بده أحط الـ
+
+430
+00:41:48,760 --> 00:41:53,260
+Nucleotide واحد ورا الثاني الحبل هذاراح يكون
+
+431
+00:41:53,260 --> 00:41:56,440
+تقريبًا بغطي الكورة الأرضية أو نص الكورة الأرضية
+
+432
+00:41:56,440 --> 00:42:01,860
+يعني مسافة طويلة جدًا ربنا حطه عشان تقدر تدخله كله
+
+433
+00:42:01,860 --> 00:42:04,960
+هيك في قطعة صغيرة في مكان صغير بتحشره في مكان صغير
+
+434
+00:42:04,960 --> 00:42:10,300
+إنك هيك بيصير يلف على بعضه أكثر وأكثر وأكثر فأول
+
+435
+00:42:10,300 --> 00:42:14,600
+Double Helix إذا بناخد نتصور كيف تركيبه على مستوى
+
+436
+00:42:14,600 --> 00:42:24,890
+إنه 2 نانومتر يعني 2×10 أو 2-9 متربصير بعدين يلف
+
+437
+00:42:24,890 --> 00:42:28,810
+بشكل أكبر طبعاً حتى تلفه بشكل أكبر بدك شوية
+
+438
+00:42:28,810 --> 00:42:33,670
+بروتينات بدك أشياء ثانية حتى تسمعله يلف أكثر عشان
+
+439
+00:42:33,670 --> 00:42:43,910
+يعرف يدخل وهذا اللي هو يعني اللي
+
+440
+00:42:43,910 --> 00:42:48,830
+بيسمونه «Nucleosome Fiber» اللي هو الـ Beads in a
+
+441
+00:42:48,830 --> 00:42:56,560
+Stringيعني عبارة عن أنه كل، عشان تقدر تخلّي تربطه
+
+442
+00:42:56,560 --> 00:43:01,700
+بشكل تستعرف تستعرف تعمل عملية Cell Division،
+
+443
+00:43:01,700 --> 00:43:07,840
+بحنأخد عنها وكيف تفصلها عن بعض، بتلاقي أن الـDNA
+
+444
+00:43:07,840 --> 00:43:12,520
+بلف بشكل أكثر
+
+445
+00:43:12,520 --> 00:43:17,880
+وأكثر وأكثركل ما أكبرت، بتشوف إنه فيه اسمه بيسموه
+
+446
+00:43:17,880 --> 00:43:23,020
+«نيكليوسون فايبر»، وبعدين اسمه «سلينويد»، ماشي،
+
+447
+00:43:23,020 --> 00:43:28,520
+وبعدين اللي هي الـ «سيلز إن إيرلي»، interface،
+
+448
+00:43:28,520 --> 00:43:33,580
+وبتكون الأمور بهذا الشكل الموضوع يعني حتى تتخيلوا
+
+449
+00:43:33,580 --> 00:43:41,910
+إنه لما أنا في خلية، بديأسوي عملية اللي بدنا
+
+450
+00:43:41,910 --> 00:43:46,510
+نتاخدها بعدين اللي هي عملية تحويل الـ DNA المادة
+
+451
+00:43:46,510 --> 00:43:51,270
+أو المعلومات اللي في الـ DNA أحولها لـ RNA بسميها
+
+452
+00:43:51,270 --> 00:43:56,430
+Transcription وبعدين لما أحول المادة أو المعلومات
+
+453
+00:43:56,430 --> 00:44:01,470
+اللي موجودة في الـ RNA لبروتين أسميها عملية
+
+454
+00:44:01,470 --> 00:44:05,250
+Translation فحتى أعمل عملية الـ Transcription هذه
+
+455
+00:44:05,250 --> 00:44:11,530
+بدي أخد قطعةتبعت الـ «جين» من الـ «DNA» وأفرطها
+
+456
+00:44:11,530 --> 00:44:16,490
+شوية السلة من اللي حكينا عنه بدي أبعده شوية عن بعض
+
+457
+00:44:16,490 --> 00:44:21,950
+وبدي أنقل المعلومات اللي موجودة على جهة عن طريق
+
+458
+00:44:21,950 --> 00:44:27,590
+Messenger RNA وبدي أسوي عملية Transcription هذه
+
+459
+00:44:27,590 --> 00:44:34,310
+بدي تكون الـ «DNA» فارض بدي تكون الـ «DNA» بعيد عن
+
+460
+00:44:34,310 --> 00:44:40,930
+بعضه وفارضأما لما بدي أجي أعمل عملية زي قضية الـ
+
+461
+00:44:40,930 --> 00:44:48,070
+Silk Division حتى إذا أنت بتتخيل معاك مثلا اللي هم
+
+462
+00:44:48,070 --> 00:44:55,310
+اللي بيشتغلوا الحجيات بالسنارة و بيكون معاهم خيط
+
+463
+00:44:55,310 --> 00:45:02,470
+ماشي إذا بدي أفصل مجموعة خيطين كرتين خيطان عن بعض
+
+464
+00:45:02,470 --> 00:45:09,540
+لو الخيط هيكي فالتوسيح ومفروض راح تلاقي أنه صعب
+
+465
+00:45:09,540 --> 00:45:14,420
+جدا تفصلن عن بعض بس لو أسير ألف الخيط لحيث أنه
+
+466
+00:45:14,420 --> 00:45:21,760
+أعمله بشكل طبي أعمله بشكل كتلة متماسكة ومربوطة على
+
+467
+00:45:21,760 --> 00:45:26,600
+بعض بيصير أن أفصل أثنتين هدول عن بعض سهل جدا ففي
+
+468
+00:45:26,600 --> 00:45:32,730
+حالةإنه بيكون الواحد بيشتغل على الـ DNA وبأخد منه
+
+469
+00:45:32,730 --> 00:45:35,470
+البروتينات وبأخد منه المعلومات وبسوّيله
+
+470
+00:45:35,470 --> 00:45:39,970
+Transcription وTranslation والأشياء هذه، بدي يكون
+
+471
+00:45:39,970 --> 00:45:44,590
+الـ DNA فارض وهي بيكون في مرحلة اللي بتسميها
+
+472
+00:45:44,590 --> 00:45:49,570
+Interface بتكون في المرحلة الخلية بتشتغل على الـ
+
+473
+00:45:49,570 --> 00:45:53,490
+DNA، بتشغّل الـ DNA وجيناتهوبتسوي الأشياء اللي
+
+474
+00:45:53,490 --> 00:45:59,570
+مطلوبة منه بس في لحظة معينة لما تتكلم عن إنه أنا
+
+475
+00:45:59,570 --> 00:46:05,450
+ما بدي الـ DNA هذا أشتغل عليه بهمني أن يكون الكرة
+
+476
+00:46:05,450 --> 00:46:11,310
+مطبوبة بالذات في وقت الـ Cell Division بيكون … ما
+
+477
+00:46:11,310 --> 00:46:17,850
+هو اسمه؟ بيكون … يعني Condensed بيكون مكثف، بيكون
+
+478
+00:46:17,850 --> 00:46:24,510
+مربوط على بعض، واضح؟فيه إشي فيه حد مش فاهم؟ فيه حد
+
+479
+00:46:24,510 --> 00:46:28,130
+عنده سؤال؟
+
+480
+00:46:28,130 --> 00:46:39,530
+واضح دكتور أحمد؟ إذا فيه حد عنده سؤال يسأل فهذا
+
+481
+00:46:39,530 --> 00:46:48,350
+نتكلم، نسميه اللي هنا يعني التركيب أو درجات تعقيد،
+
+482
+00:46:48,350 --> 00:46:49,850
+تركيب أو
+
+483
+00:46:54,000 --> 00:46:59,220
+الـ Packaging يعني اللي هي تغليف الـ DNA في الـ
+
+484
+00:46:59,220 --> 00:47:04,640
+Chromosome البشري فاللي بيبدأ من أنه الـ Double
+
+485
+00:47:04,640 --> 00:47:09,720
+Helix بعدين بيلف أكثر عن طريق الـ Histone راح نحكي
+
+486
+00:47:09,720 --> 00:47:13,600
+عنه مرات فيه له أهميات في أمراض وأحالات وأشياء
+
+487
+00:47:14,320 --> 00:47:19,180
+وبعدين بنشكله على شكل الـ Steel، الـ Slinoids
+
+488
+00:47:19,180 --> 00:47:25,980
+وبعدين بيكون موجود سواء في حالة الـ Interface أو
+
+489
+00:47:25,980 --> 00:47:29,580
+في حالة لما نعمل الـ Cell Division لقضية أن عندي
+
+490
+00:47:29,580 --> 00:47:34,680
+يكون كرموزومات مثبتة على بعض، بتغليف معين، بترتيب
+
+491
+00:47:34,680 --> 00:47:39,920
+معين، في أسئلة؟ ‏- سيهم، عندها سؤال ‏- أه، اسألي
+
+492
+00:47:41,510 --> 00:47:46,170
+بتسأل إنه كيف بيكون مفكوك في انقسام الخلية أعتقد
+
+493
+00:47:46,170 --> 00:47:51,890
+جزد عن الـ«نيكليوزوم فايبر» يعني أو بشكل عام
+
+494
+00:47:51,890 --> 00:47:57,110
+الـDNA واحنا لازم نقسمها لخليتين لأ، لأ، لأ، أنت
+
+495
+00:47:57,110 --> 00:48:06,930
+الآن الـDNA بيكون بين حالتين في حالة بدي أقرا
+
+496
+00:48:06,930 --> 00:48:11,230
+المادة اللي فيه عشان أكول بروتين الخلية هذه بدهيها
+
+497
+00:48:11,880 --> 00:48:16,900
+فعشان تقراه، راح ناخد بعد شوية راح يكون إنه لازم
+
+498
+00:48:16,900 --> 00:48:22,360
+الـ DNA هذا يكون فارق يعني لازم يكون حتى الـ
+
+499
+00:48:22,360 --> 00:48:27,480
+Double Strand هذا اللي هو هنا لازم يكون نفصله عن
+
+500
+00:48:27,480 --> 00:48:32,820
+بعض عشان تعرف نصل إله يعني هذه الـ … الـ … الـ
+
+501
+00:48:32,820 --> 00:48:37,460
+chromosome الواحد راح ناخد ما لا يقل عن ألف gene
+
+502
+00:48:37,460 --> 00:48:41,750
+فيهيعني بيكون فيه عدد كبير من الجينات مش كلها
+
+503
+00:48:41,750 --> 00:48:46,910
+شغالة مش كلها بده يتم يعني عملية الـ Transcription
+
+504
+00:48:46,910 --> 00:48:52,330
+تبعتها لـ RNA بده يكون عدد قليل بس اللي شو اسمه
+
+505
+00:48:52,330 --> 00:48:57,510
+محتوط الـ DNA اللي يعني بتصير عملية الـ
+
+506
+00:48:57,510 --> 00:49:02,250
+Transcription يعني في أي خلية عدد قليل من الجينات
+
+507
+00:49:02,250 --> 00:49:05,610
+بتتم قراءتها اللي هي عملية الـ Transcription
+
+508
+00:49:05,610 --> 00:49:09,640
+تبعتهافلما أنا بدي أعمل transcription بدي أكون
+
+509
+00:49:09,640 --> 00:49:14,120
+فارض زي هيكي بس لما أجي أعمل عملية cell division
+
+510
+00:49:14,120 --> 00:49:20,460
+بدي أكون انبكت مظبوط بشكل بحيث أنه أفصله عن بعض
+
+511
+00:49:20,460 --> 00:49:27,140
+كخطعتين فهنجي ناخد صورة عنها، في واضحة؟ لسه عن
+
+512
+00:49:27,140 --> 00:49:30,800
+سياق المشكلة؟
+
+513
+00:49:30,800 --> 00:49:39,160
+لأ لأ الأمور واضحة بالنسبة لهافيعني هذه صورة
+
+514
+00:49:39,160 --> 00:49:46,600
+بالنسبة لكيف تركيب الأمور لما ناخد الـ Chromosome
+
+515
+00:49:46,600 --> 00:49:52,180
+الـ Chromosome يعني تقريباً راح ناخد أوصافه
+
+516
+00:49:52,180 --> 00:49:58,690
+وأشكاله وكذابارعاً شكل بالأخير يعني ممكن يكون على
+
+517
+00:49:58,690 --> 00:50:06,670
+شكل حبل طويل وهكذا ولمّا نأخذه بشكل اللي هو عند
+
+518
+00:50:06,670 --> 00:50:11,810
+اللي بيسموه في الـ Karyotype من اللي بيسموه عند
+
+519
+00:50:11,810 --> 00:50:19,150
+دراسة الكرمозومات تبع الإنسان بشكل كبير فاحنا ناخد
+
+520
+00:50:19,150 --> 00:50:24,390
+على شكل واحدة هذه الدراسات، بيكونلو أخدنا هذا الـ
+
+521
+00:50:24,390 --> 00:50:27,690
+Chromosome ويكون بهذا الشكل فيه إشي بيسموه
+
+522
+00:50:27,690 --> 00:50:32,150
+Centromere اللي هي النقطة الأهم في قضية فصل
+
+523
+00:50:32,150 --> 00:50:36,470
+القطعتين عن بعض اللي هي بتداخل مع الـ Centrosome
+
+524
+00:50:36,470 --> 00:50:44,230
+وبيفصل الـ Two copies of DNA عن بعض لما نيجي ناخد
+
+525
+00:50:44,230 --> 00:50:49,190
+شكله عن طريق هنا شكلها Electron Microscopy اللي
+
+526
+00:50:49,190 --> 00:50:53,440
+أقيا بالأخير عبارة عن خاتم لو لولو جيت على قطعة
+
+527
+00:50:53,440 --> 00:50:57,560
+صغيرة من هذه الخيطة راح ألاقيها زي هيك دي عندى الـ
+
+528
+00:50:57,560 --> 00:51:02,280
+Double Helix الـ Double Helix يعني تلم لو لبيه
+
+529
+00:51:02,280 --> 00:51:11,360
+بينهم دعسات بتكون بنفس الترتيب فالأصل تكون مثلًا،
+
+530
+00:51:11,360 --> 00:51:17,960
+هاي على و بناخدها إنه أنا بقرا من الطرف رقم خمسة
+
+531
+00:51:17,960 --> 00:51:22,250
+«5 Prime» لـ «3 Prime»الطرف الثاني راح يكون من
+
+532
+00:51:22,250 --> 00:51:25,630
+الـ5 Prime لـ3 Prime بيكون هذا هو شكل
+
+533
+00:51:25,630 --> 00:51:31,530
+الـDeoxyribose زي الفوسفيل أما بالنصف بيكون
+
+534
+00:51:31,530 --> 00:51:36,270
+الـNitrogen Basis فهذه لما نقول إحنا قرينا
+
+535
+00:51:36,270 --> 00:51:42,390
+الـSequencing تبع الـDNA بنقول شو هي الأحرف تبعات
+
+536
+00:51:42,390 --> 00:51:49,580
+الـNitrogen Basis الموجود وعادة بناخدها دايماًمن
+
+537
+00:51:49,580 --> 00:51:55,520
+الـ5 للـ3، هيك المتعارف على أساس إن الـ3 للـ5
+
+538
+00:51:55,520 --> 00:52:02,460
+بيكون أكسر، ماشي؟ فلو أخذنا إنه أنا عندي بني آدم
+
+539
+00:52:02,460 --> 00:52:08,320
+معين اللي عملوله Human Genome، شو اسمه الـHuman
+
+540
+00:52:08,320 --> 00:52:14,320
+Genome، للقطعة هذه في الـChromosome هذا، للبروتين،
+
+541
+00:52:14,320 --> 00:52:19,490
+الله أعلم شو اللي راح يكون، يطلعه، باخد، آسف،بأخد
+
+542
+00:52:19,490 --> 00:52:23,910
+إنه هذا هو الـ Double Helix وهكذا يكون الـ
+
+543
+00:52:23,910 --> 00:52:28,410
+Reference Sequence لما نتعامل إحنا كعلماء وطباء
+
+544
+00:52:28,410 --> 00:52:31,850
+نيجي مثلا نتناقش بعد شوية على «تميليا»
+
+545
+00:52:31,850 --> 00:52:36,150
+الـMediterranean fever و لا أي مرض وراثي تاني،
+
+546
+00:52:36,150 --> 00:52:39,370
+بتلاقي لما نقول على القطعة هذه وشو هو الـReference
+
+547
+00:52:39,370 --> 00:52:44,260
+Sequence اللي إحنا بنستخدمه، تلقائيًا راح ناخدعشان
+
+548
+00:52:44,260 --> 00:52:48,160
+ما أتعقدش الموضوع من الخمس إلى الثلاث فدايماً
+
+549
+00:52:48,160 --> 00:52:52,760
+بقراهم من الخمس إلى الثلاث فهنا عملوا تجربة إنه
+
+550
+00:52:52,760 --> 00:52:57,700
+جابوا خمس أشخاص درسوا
+
+551
+00:52:57,700 --> 00:53:04,400
+هذه القطعة وشافوا الـSequence تبعها ولقوا إنه في
+
+552
+00:53:04,400 --> 00:53:09,720
+حالة مثلا الشخص الأول كان اللي هو الـReference
+
+553
+00:53:09,720 --> 00:53:14,180
+Sequence وكان هو أول إنسان إحنا درسناهفما جيبنا
+
+554
+00:53:14,180 --> 00:53:18,720
+بني آدم ثاني وعندي حسا الأن إمكانيات إني أدرس
+
+555
+00:53:18,720 --> 00:53:26,020
+الاختلافات الـ Polymorphism اللي هي الـ الـ الـ
+
+556
+00:53:26,020 --> 00:53:31,240
+يعني الاختلافات حتى على مستوى single nitrogen
+
+557
+00:53:31,240 --> 00:53:36,780
+bases فبحيث إنه الشخص الأول والشخص الثاني في هذا
+
+558
+00:53:36,780 --> 00:53:41,620
+المكان بدل ما هي الـT زي ما هو بالـReference في C
+
+559
+00:53:41,620 --> 00:53:48,110
+وCفهذه طبعًا الـ «T» بيكون إقبالها «A» فلما يكون
+
+560
+00:53:48,110 --> 00:53:53,750
+هنا «C» بيكون إقبالها «G» فهذولة Individual 2، 3
+
+561
+00:53:53,750 --> 00:53:57,850
+عندهم هذا الخلال في هذا المكان بقول على الموقع،
+
+562
+00:53:57,850 --> 00:54:04,310
+هذا بسمي 1، 2، 3، 4، 5، 6، 7، هنا رقم 8، هنا رقم
+
+563
+00:54:04,310 --> 00:54:14,080
+مثلًا 20 بدل ما هي «C» كانت «A»الشخص الخامس تم
+
+564
+00:54:14,080 --> 00:54:21,320
+إزالة إثنين نيكليوتايد أو إثنين Bases بحيث إن الـ
+
+565
+00:54:21,320 --> 00:54:27,020
+«T» أجت بعد «C» فهي أقصر طبعاً هنا بيحاولوا إنه،
+
+566
+00:54:27,020 --> 00:54:34,440
+شو اسمه، يعني هذه الأخيرة زي ما هم شرحينكم هنا،
+
+567
+00:54:34,440 --> 00:54:40,620
+هنا صار «Deletion» يعني لسبب أو لآخر انقطعالـ Two
+
+568
+00:54:40,620 --> 00:54:44,300
+Nucleotides إن شاء الله فالـ T أجت وراها بعدها الـ
+
+569
+00:54:44,300 --> 00:54:48,300
+C يعني هاي الـ T أجت بدل ما يكون فيه Two Ts بعدها
+
+570
+00:54:48,300 --> 00:54:52,120
+من تان تيات أجت بعدها الـ C مباشرة فالمفروض هذا
+
+571
+00:54:52,120 --> 00:54:57,840
+يكون شكله أصغر فهذا بيعمل برضه خاصية ويرافية أخرى
+
+572
+00:54:57,840 --> 00:55:03,640
+فالمطلوب هنا أو الفكرة اللي بيشرحوها هنا إنه
+
+573
+00:55:03,640 --> 00:55:07,360
+الترتيب
+
+574
+00:55:09,120 --> 00:55:17,620
+القواعد النيتروجينية في الـ DNA هو ما يتحكم
+
+575
+00:55:17,620 --> 00:55:22,880
+بالأحرف أو الـ Amino Acids اللي راح تيجي بالبروتين
+
+576
+00:55:22,880 --> 00:55:29,380
+اللي راح تيجي في الـ اللي تمثل المادة الوراثية
+
+577
+00:55:29,380 --> 00:55:40,160
+وتمثل المظهر الخارجي بعدين لأي كل إنسان، ففي حد
+
+578
+00:55:40,160 --> 00:55:46,040
+بيسأل سؤال، يلّا إذا أسأله، شو السؤال؟ أنا مش شايف
+
+579
+00:55:46,040 --> 00:55:56,860
+الـChat وحتى صورتي راحت، آه، في سؤال؟
+
+580
+00:55:56,860 --> 00:56:07,100
+في واحد رفع إيده، كريم، دكتور أحمد،
+
+581
+00:56:14,510 --> 00:56:19,670
+الدكتور أحمد، في حد عنده سؤال أنا أشوف إذا في الـ
+
+582
+00:56:19,670 --> 00:56:39,930
+«تشات»، وين الـ«تشات»؟ ماشي،
+
+583
+00:56:39,930 --> 00:56:48,140
+الأحيانًايعني مش ضروري الإنسان الأول هو يكون، شو
+
+584
+00:56:48,140 --> 00:56:54,160
+اسمه؟ هو السليم والتاني مصاب إحنا هنا الفكرة إنه
+
+585
+00:56:54,160 --> 00:57:02,340
+أنا من دراستي لتركيب الـDNA بسوي Sequence لإيش هم،
+
+586
+00:57:02,340 --> 00:57:07,960
+ليه واحدة من أربعة من الـNitrogen Bases
+
+587
+00:57:07,960 --> 00:57:11,420
+الـNitrogen Bases دو بالأخير هم اللي بتحكموا
+
+588
+00:57:11,420 --> 00:57:19,520
+بالبروترفلما أنا آجي أدرس مثلا نفترض أنه بدي أدرس
+
+589
+00:57:19,520 --> 00:57:24,940
+الـ gene تبع الـ Alpha chain تبع الـ hemoglobin
+
+590
+00:57:24,940 --> 00:57:33,320
+فبروح بشوف إنسان مثلا الشخص الأولمثلاً اللي هو
+
+591
+00:57:33,320 --> 00:57:37,120
+«باعتبره أنه كان طبيعي» «والإنسان اللي ماعلوش
+
+592
+00:57:37,120 --> 00:57:41,460
+مشكلة» «وباعتبره طبيعي» يعني أحيانًا الـReference
+
+593
+00:57:41,460 --> 00:57:45,480
+Sequence هذا ممكن يكون لإنسان مريض أو إنسان طبيعي
+
+594
+00:57:45,480 --> 00:57:50,000
+بس هو الأول اللي اعتمدنا عليه في دراسة هذا القطعة
+
+595
+00:57:50,000 --> 00:57:54,900
+من الـDNA يعني هذه الفكرة الأولى فإذا أنا الإنسان
+
+596
+00:57:54,900 --> 00:58:02,110
+الأول كان بهذا الشكل وبعدينبدرس شخص تاني وثالث
+
+597
+00:58:02,110 --> 00:58:07,170
+ورابع وخامس وعشر ومليون ومليونين بقدر أظن أدرس،
+
+598
+00:58:07,170 --> 00:58:13,650
+بشوف شو الاختلافات وبتكون إنه أنا في الأصل في
+
+599
+00:58:13,650 --> 00:58:22,230
+الغالب العمود الفقري تبع ترتيب الـ «جين» هذا لهذا
+
+600
+00:58:22,230 --> 00:58:28,950
+البروتين بكون بشكل معين، فبعتبره الأساسيلما أجي
+
+601
+00:58:28,950 --> 00:58:35,750
+أسوي report لـ الـ reference sequence هذا هو تبع
+
+602
+00:58:35,750 --> 00:58:42,230
+أول إنسان درسناه أو أول إنسان سويتله sequence على
+
+603
+00:58:42,230 --> 00:58:48,510
+افتراض أنه إنسان طبيعي فلما أجي أجيب لإنسان ثاني
+
+604
+00:58:48,510 --> 00:58:54,380
+وهنا أنا سويت لأربعة غيره لاقيت أنهOkay، هذا
+
+605
+00:58:54,380 --> 00:58:58,320
+الإنسان الأول بهذا الشكل فيه شخصين كان عندهم
+
+606
+00:58:58,320 --> 00:59:03,540
+بيسموه Single Nucleotide Polymorphism يعني فيه
+
+607
+00:59:03,540 --> 00:59:11,700
+تفديل في موقع معين لحرف تبع الـNitrogen Space وفي
+
+608
+00:59:11,700 --> 00:59:17,180
+شخص رابع عنده اختلاف في محل تاني بنوعية أخرى وفي
+
+609
+00:59:17,180 --> 00:59:22,960
+شخص ثالث، خامسكان، ما هو اسمه؟ حتى فيه الـDeletion
+
+610
+00:59:22,960 --> 00:59:26,580
+فطبعاً الـDeletion راح تقصر، راح تغير كله، راح
+
+611
+00:59:26,580 --> 00:59:32,020
+تتغير بشكل كبير يعني يمكن الاختلافات اللي موجودة
+
+612
+00:59:32,020 --> 00:59:38,260
+عند 2 و3 و4 اختلافات بسيطة، يمكن ما تكونش مؤثرة
+
+613
+00:59:38,260 --> 00:59:42,440
+لأنه راح ناخد بعد شوية إنه أحياناً حتى لو تغيرت
+
+614
+00:59:42,440 --> 00:59:47,960
+الـNucleotideونوعية الـ Nitrogen Base ممكن ما
+
+615
+00:59:47,960 --> 00:59:51,440
+يتغير البروتين يعني مش دايماً لازم يتغير البروتين
+
+616
+00:59:51,440 --> 00:59:55,780
+بس لما يبدأ تنشالة فنتين هدولة يصير الـ Deletion
+
+617
+00:59:55,780 --> 01:00:02,260
+هذا خطأ يعني راح يخرّب كل الشغل يعني آه، في أسئلة؟
+
+618
+01:00:02,260 --> 01:00:08,880
+دكتور، في يعني ردت أسئلة كانت في الـChat وفي كريم
+
+619
+01:00:08,880 --> 01:00:13,160
+بده يحكي آه، يحكي أول حاجة، دعنا نشوف كريم
+
+620
+01:00:17,480 --> 01:00:24,700
+فضّالة كريم يطيبك العرف يا دكتور أول حاجة اللي
+
+621
+01:00:24,700 --> 01:00:28,980
+أخدنا في مساق سابق أنه الجين اللي عند الإنسان
+
+622
+01:00:28,980 --> 01:00:34,580
+تقريبا 99% متشابه كل الناس متشابه فيه وبظال نسبة 1
+
+623
+01:00:34,580 --> 01:00:37,980
+% أن هذه اللي هي الـdifferent أو بتتميز الناس عن
+
+624
+01:00:37,980 --> 01:00:43,880
+بعض صح الكلام صح؟ لأ مش ضروري هيك ما بذكر أنه قريت
+
+625
+01:00:43,880 --> 01:00:51,670
+هذا الموضوع هيك فيه تفاصيل كتيرةشوف حوالي تقريبًا
+
+626
+01:00:51,670 --> 01:00:57,810
+يعني 95% من الـ «DNA» تبع الإنسان بيسموه «Non
+
+627
+01:00:57,810 --> 01:01:06,290
+-coding DNA» يعني هذا الـ «اسام» مش كل الـ «DNA»
+
+628
+01:01:06,290 --> 01:01:14,680
+تبع الإنسان فيه جيناتفيه زي ما تقول عبارة عن فراطة
+
+629
+01:01:14,680 --> 01:01:20,440
+كثير لقضية اللف والـ Packaging وكذا ففيه نسبة
+
+630
+01:01:20,440 --> 01:01:24,720
+كبيرة على عكس الحيوانات الأخرى في كائنات حي ثانية
+
+631
+01:01:24,720 --> 01:01:28,480
+تقريبًا كل الـ DNA تبعها يستخدم في الـ
+
+632
+01:01:28,480 --> 01:01:32,720
+Transcription والـ Translation لإنه يكون ينتج عنه
+
+633
+01:01:32,720 --> 01:01:42,170
+البروتين فبالنسبة للإنسانجزء كبير مش مهم، بس بين
+
+634
+01:01:42,170 --> 01:01:48,390
+البشر هل هناك اختلافات في الـ «DNA»؟ فيه أشياء
+
+635
+01:01:48,390 --> 01:01:53,970
+يحافظ عليها، وبتكون مدى إذا قطعة صغيرة أو أنواع
+
+636
+01:01:53,970 --> 01:01:58,330
+ولا كده، يعني بس فيه اختلافات، يعني أنت لما تيجي
+
+637
+01:01:58,330 --> 01:02:05,570
+تاخد مثلًا لموقع الـ «ABO System»، ماشي؟الـ «جين»
+
+638
+01:02:05,570 --> 01:02:11,350
+مثلًا، في ناس «A» و«B» و«AB» و«O» باختلاف، لو انت
+
+639
+01:02:11,350 --> 01:02:14,990
+واخد الـ «HLA System» فيه اختلافات كبيرة على مستوى
+
+640
+01:02:14,990 --> 01:02:19,810
+إنه ما لا يقل على الـ «HLA» مثلًا، «A» فيه حوالي
+
+641
+01:02:19,810 --> 01:02:25,650
+300، 400 نوع، فما تقولي إن البشر كلهم متشابين، بس
+
+642
+01:02:25,650 --> 01:02:31,350
+نسبة كبيرة من الـ «DNA» تبع الإنسانلأ، ما بيتم
+
+643
+01:02:31,350 --> 01:02:35,850
+تحويله
+
+644
+01:02:35,850 --> 01:02:38,850
+إلى Transcription أو Translation فهذه يعطينا
+
+645
+01:02:38,850 --> 01:02:43,970
+البروتين، فبيعتبروه Non-coding وهذا أحيانًا مهم في
+
+646
+01:02:43,970 --> 01:02:55,030
+عملية التحكم في تكوين البروتين يعني، لأ يعني، بدك
+
+647
+01:02:55,030 --> 01:03:02,420
+تتخيل مثلًاأنا عندي بروتين، سامعني يا كريم؟ آه
+
+648
+01:03:02,420 --> 01:03:08,720
+تمام. هسة مثلا، البروتين، الـGene تبع
+
+649
+01:03:08,720 --> 01:03:15,280
+الـHemoglobin، ماشي؟ وين موجود؟ في الـDNA، صح؟
+
+650
+01:03:15,280 --> 01:03:24,600
+أنيه خلية فيها هذا البروتين، الـGene؟ جاوبني، شو
+
+651
+01:03:24,600 --> 01:03:31,830
+رايك؟ في الـRBCلأ، طبعًا الـ «جين» الـ «جين» تبع
+
+652
+01:03:31,830 --> 01:03:37,870
+الـ Hemoglobin موجود في كل الخلايا، شايف علي؟ كله
+
+653
+01:03:37,870 --> 01:03:42,990
+زي بعض، الـ DNA صحيح، كان في جواب من الكل إنه
+
+654
+01:03:42,990 --> 01:03:47,070
+موجود في كل الخلايا، صحيح؟ آه، فهو موجود في كل
+
+655
+01:03:47,070 --> 01:03:52,540
+الخلايا، بسفقط في الـ Red Blood Cells بتم تفعيل
+
+656
+01:03:52,540 --> 01:03:57,080
+هذا الجين بالذات بس عشان ينتجلي الـ Hemoglobin
+
+657
+01:03:57,080 --> 01:04:01,280
+فبهذه الناحية بدنا نفهمها يعني خلية الجل بيدا
+
+658
+01:04:01,280 --> 01:04:03,680
+كيراتين بدهاش Hemoglobin، شوف ده بالـ Hemoglobin
+
+659
+01:04:03,680 --> 01:04:08,160
+خلية الـ B-Lymphocytes بتطلع Immunoglobin خلية الـ
+
+660
+01:04:08,160 --> 01:04:13,120
+T-Cells بالمنعقة بتطلعك كذا، خلية كذا كل واحدة حسب
+
+661
+01:04:13,120 --> 01:04:17,540
+شغلها بتشغل إشي وبدهاش الأشياء التانيةفالأشياء
+
+662
+01:04:17,540 --> 01:04:23,320
+الثانية بتظلها خاملة، بتظلها ساكتة في الإنسان
+
+663
+01:04:23,320 --> 01:04:28,640
+بالذات، نسبة كبيرة من الـ DNA بيسموه Non-coding
+
+664
+01:04:28,640 --> 01:04:32,700
+DNA يعني ما بيتم استفادة منه في عملية الـ
+
+665
+01:04:32,700 --> 01:04:35,300
+Transcription و Translation بحيث يعطينا الـ
+
+666
+01:04:35,300 --> 01:04:41,530
+Protein، ولكناللي يعني بيظنوا إنه له دور في
+
+667
+01:04:41,530 --> 01:04:44,750
+الحماية من الـ mutation يعني لو صار خراب في هذا
+
+668
+01:04:44,750 --> 01:04:48,190
+الجزء ما هو non-coding مش مهم كثير، من ناحية
+
+669
+01:04:48,190 --> 01:04:54,710
+والناحية الثانية إنه بتحكم في أينه خلية نشغل هذا
+
+670
+01:04:54,710 --> 01:04:59,210
+الـ gene يعني هيك يعني، فياسة أخرى فالآن اللي
+
+671
+01:04:59,210 --> 01:05:07,000
+قدامنا يعني إنه على العكس الـ single nucleotideالـ
+
+672
+01:05:07,000 --> 01:05:14,780
+Polymorphism اللي هي هذه الظاهرة في هذه الرسمة
+
+673
+01:05:14,780 --> 01:05:19,000
+علاقة شائعة جداً جداً ومرات ما لهاش قيمة يعني لأنه
+
+674
+01:05:19,000 --> 01:05:23,540
+راح ناخد بعد شوية الـ Triplets هدولة اللي هي كل
+
+675
+01:05:23,540 --> 01:05:26,380
+ثلاثة نيوكليوتات بيعطينا واحد Amino Acid زي ما
+
+676
+01:05:26,380 --> 01:05:31,400
+بتعرفوا هذه بتتم من خلال أن أحيانًا أكثر من
+
+677
+01:05:31,400 --> 01:05:33,240
+Triplets لأنه
+
+678
+01:05:41,210 --> 01:05:42,610
+4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4
+
+679
+01:05:44,260 --> 01:05:48,260
+فيها سؤال أخر؟ دكتور، في المعظم يعني بيقول إيش
+
+680
+01:05:48,260 --> 01:05:53,080
+الفكرة اللي بده توصلها الـslide؟ يعني هم قضية
+
+681
+01:05:53,080 --> 01:05:57,180
+الـReference Sequence بناخده إحنا عن أحد
+
+682
+01:05:57,180 --> 01:05:59,960
+الـStrands تبعوت اللي هو الـDouble Helical بيشكل
+
+683
+01:05:59,960 --> 01:06:02,840
+كرمزوم وبيطلع عندنا فيه اختلافات ما بين
+
+684
+01:06:02,840 --> 01:06:05,880
+الـIndividuals مع الـReference Sequence إيش الفكرة
+
+685
+01:06:05,880 --> 01:06:09,700
+اللي أنا بده أصلها يعني معلومة اللي بدي توصلها
+
+686
+01:06:09,700 --> 01:06:13,380
+الـslide بشكل عام؟ هم هيك السؤال يعني آه، الفكرة
+
+687
+01:06:13,380 --> 01:06:21,200
+إنهلما أنا في العلم لما بدأ أدرس موضوع بدأت القضية
+
+688
+01:06:21,200 --> 01:06:25,360
+حكينا من قبل اسم الـ Human Genome الـ Human Genome
+
+689
+01:06:25,360 --> 01:06:30,000
+أخدوا بني آدم واحد فانت بدأت تبدأ في مرحلة معينة
+
+690
+01:06:30,000 --> 01:06:33,940
+فلما تبدأ أخذنا الـ Human Genome أنا أظن يعني هاي
+
+691
+01:06:33,940 --> 01:06:39,500
+واحد ذكرليها كمعلومة إنه الإنسان ما هو بدك تاخد
+
+692
+01:06:39,500 --> 01:06:43,700
+إنسان واحد لأن كلنا مختلفين عن بعضشايف عليا؟ ناخد
+
+693
+01:06:43,700 --> 01:06:46,900
+مادة وراثية من الأب ومن الأم ومن الـ Mitochondria
+
+694
+01:06:46,900 --> 01:06:51,660
+لوحده وكذا أنا أظن أسمعت إنه بيقولوا إنه مدير
+
+695
+01:06:51,660 --> 01:07:01,380
+البنك الدولي اللي هو موّل بمليارات المشروع
+
+696
+01:07:01,380 --> 01:07:04,700
+الـ Human Genome هو الإنسان اللي أخذوا الـ DNA
+
+697
+01:07:04,700 --> 01:07:09,950
+تبعه أنت بدك تبدأ في لحظة معينةكيف بدك يعني من وين
+
+698
+01:07:09,950 --> 01:07:15,250
+بدك تعرف أنه يعني بد يكون عندك مرجع بالأول ترجعله
+
+699
+01:07:15,250 --> 01:07:19,470
+تقيس باقية الأشياء عليه يمكن هذا الإنسان هو عنده
+
+700
+01:07:19,470 --> 01:07:23,610
+أمراضه عنده اختلافات معينة عن غيره فهل
+
+701
+01:07:23,610 --> 01:07:26,530
+الـReference Sequence هو أشياء، إشي دايماً ما بعرف
+
+702
+01:07:26,530 --> 01:07:32,350
+يعني ماعندي معلومة إنه هو إشي طبيعي يعني مافيش إشي
+
+703
+01:07:32,350 --> 01:07:37,820
+اسمه طبيعي بينما كل إنسان له ميزات معينةفلما
+
+704
+01:07:37,820 --> 01:07:42,520
+انتوا، الواحد بعدين راح ياخد كيف ببحث في المواضيع
+
+705
+01:07:42,520 --> 01:07:47,540
+هذه وبسوي Blast وبسوي بعد الـSequencing أو بستخدم
+
+706
+01:07:47,540 --> 01:07:52,440
+PCR وكده، لما انت قيم هذا الموضوع، بدخل على قواعد
+
+707
+01:07:52,440 --> 01:07:57,420
+البيانات تبع الترتيب، الـSequence هذا، بشوف هذا
+
+708
+01:07:57,420 --> 01:08:04,290
+بشبه أيش وبصير أقارن فيه، فلازم أنا بالأول أاخدلأي
+
+709
+01:08:04,290 --> 01:08:09,550
+جين أو لأي مكان سيكوينس معين بصير أعتبره هذا هو
+
+710
+01:08:09,550 --> 01:08:15,090
+الـReference وبصير بعدين أشوف لما أخد حالي ثاني أو
+
+711
+01:08:15,090 --> 01:08:21,010
+شخص آخر أو إنسان آخر بشوف قداش درجة الاختلافات
+
+712
+01:08:21,010 --> 01:08:27,390
+وبقيم وضع هذا القطعة من الـDNA أو هذا الجين آه،
+
+713
+01:08:27,390 --> 01:08:33,290
+واضح؟يا دكاتر أو يا دكتور، إذا كان الصورة واضحة أو
+
+714
+01:08:33,290 --> 01:08:38,890
+المطلوب من الـslide واضح، يعني بنكمل، إسألوا مرة
+
+715
+01:08:38,890 --> 01:08:42,690
+ثانية، مافي مشكلة، الدكتور طبعاً مافي عنده مشكلة
+
+716
+01:08:42,690 --> 01:08:49,550
+إنه يوضح النقطة بالزيادة الـHuman Genome بس انتهى،
+
+717
+01:08:49,550 --> 01:08:55,210
+يعني هو البدايةوالكلام من سنة الـ، يعني خلص يمكن
+
+718
+01:08:55,210 --> 01:09:01,030
+أظن 2003، 2004 إنه عملوا الـSequence لكل إنسان
+
+719
+01:09:01,030 --> 01:09:06,030
+واحد واعتبروه هو Reference Sequence فلما واحد
+
+720
+01:09:06,030 --> 01:09:12,530
+يدرس، يعني أنا لما أجي مثلا أدرس ظاهرة معينة في
+
+721
+01:09:12,530 --> 01:09:18,010
+المناعة مثلا، بلاقي مرات بروتين، باكتشف بروتين
+
+722
+01:09:18,010 --> 01:09:18,510
+جديد
+
+723
+01:09:21,620 --> 01:09:26,300
+بحاول أشوف شو كان الـ «DNA Sequence» اللي بعطينا
+
+724
+01:09:26,300 --> 01:09:32,740
+هذا البروتين لما أفهم وأقدر ألاقي وين هذا الاشي
+
+725
+01:09:32,740 --> 01:09:38,900
+موجود في الـ «Chromosome» وفي الـ «DNA» بسير بعدين
+
+726
+01:09:38,900 --> 01:09:46,060
+مرحلة أخرى متقدمة أكثر ألاحظ شو هن اختلافات البشر
+
+727
+01:09:46,060 --> 01:09:53,060
+عموما عنالـ Standard أو عن الـ Reference فبصير أنا
+
+728
+01:09:53,060 --> 01:09:56,980
+في حالات أمراض، في حالات عائلات، في حالات يعني مش
+
+729
+01:09:56,980 --> 01:10:00,600
+ضروري individual one ولا two، three، أن يكون مريض،
+
+730
+01:10:00,600 --> 01:10:05,160
+ممكن يكون، لأ، هي بس أنه في اختلافات، يعني إنه هذه
+
+731
+01:10:05,160 --> 01:10:11,540
+ظاهرة موجودة قداش نسبتها 100% بالنسبة للدراسات،
+
+732
+01:10:11,540 --> 01:10:17,510
+لإيش هي والله أنا ما بعرف يعني إنها بالكم يعنيطب
+
+733
+01:10:17,510 --> 01:10:21,570
+يا دكتور أنا بدي أنقل سؤال و بدي أسأل أنا برضه
+
+734
+01:10:21,570 --> 01:10:27,210
+سؤال بقيت بقضية الـReference Sequence مثلا الشخص
+
+735
+01:10:27,210 --> 01:10:33,670
+اللي تم أخده لعملية الـGenome Sequencingهل تم
+
+736
+01:10:33,670 --> 01:10:39,330
+افتراض أنه هو الـ Normal؟ يعني ما تستطيع أن تبقى
+
+737
+01:10:39,330 --> 01:10:44,930
+هو الـ Normal؟ أه صحيح، وممكن
+
+738
+01:10:44,930 --> 01:10:51,810
+يكون في عضل الجينات لأمراض لكن ما تم ترجمتها أو
+
+739
+01:10:51,810 --> 01:10:56,270
+غير ظاهرة، فبالتالي الـ Referenceأه صحيح، يعني
+
+740
+01:10:56,270 --> 01:10:59,890
+السؤال هل الـ «reference» هو اللي هيكون مرجع
+
+741
+01:10:59,890 --> 01:11:04,750
+لدراسة بس مقارنة ومشابهة، مش مرجع إنه نقول ما ..
+
+742
+01:11:04,750 --> 01:11:09,170
+ما .. عقل ما بقدر أقول إن هذا إنسان سليم وغيره هو
+
+743
+01:11:09,170 --> 01:11:15,230
+إنسان مريض، لأ، ما مش إيه، بس ك .. لما تيجي تدرس
+
+744
+01:11:15,230 --> 01:11:22,190
+ال .. يعني طبعا إحنا بنتكلم عن حوالي خمس وعشرين
+
+745
+01:11:22,190 --> 01:11:27,680
+ألف geneاللي هو اللي يعني بتوقعوا إنه فيها إلى
+
+746
+01:11:27,680 --> 01:11:32,260
+بيسموه الـ Promoter والـ End codon واللي هي يعني
+
+747
+01:11:32,260 --> 01:11:36,120
+القطعة اللي بتتم ترجمتها من خلال الـ Transcription
+
+748
+01:11:36,120 --> 01:11:41,360
+للـ RNA وبعدين الـ Protein فالقطع اللي زي هيك فيه
+
+749
+01:11:41,360 --> 01:11:47,360
+حوالي 25 ألف Gen فالـ الـ الآن النقطة اللي بدل
+
+750
+01:11:47,360 --> 01:11:57,600
+واحد يصلها إنهلأغراض عملية إيجاد مرجعية لدراسة هذه
+
+751
+01:11:57,600 --> 01:12:05,520
+المواضيع تم عمل الـ Human Genome ومنه بيتم يعني
+
+752
+01:12:05,520 --> 01:12:10,340
+افتراض Reference Sequence اللي هو لقوه عند الإنسان
+
+753
+01:12:10,340 --> 01:12:15,600
+الأول اللي درسوهوبعدين بسير لما قاعد أدرس شخص
+
+754
+01:12:15,600 --> 01:12:20,260
+ثاني، ثالث، عائلة، عائلتين الـ populations مثلا كل
+
+755
+01:12:20,260 --> 01:12:25,180
+البيض السود الصينيين، الـ كذا، الـ كذا بسير أشوف
+
+756
+01:12:25,180 --> 01:12:30,180
+أنا فيه اختلافات بين الترتيب اللي هي القواعد
+
+757
+01:12:30,180 --> 01:12:36,000
+النيتروجينية في الـ DNA اللي ممكن تكون سبب في تغير
+
+758
+01:12:36,520 --> 01:12:42,320
+الصفات تبعات الـ «بروتين» والصفات اللي فاهرة على
+
+759
+01:12:42,320 --> 01:12:48,960
+الإنسان بعدين دكتور، في نقطة تانية إنه هل يمكن
+
+760
+01:12:48,960 --> 01:12:54,980
+افتراض إن غالبية اللي هو الـ «جينوم» يعني مثلا ما
+
+761
+01:12:54,980 --> 01:12:58,280
+بين الـReference وما بين individual one يعني بشكل
+
+762
+01:12:58,280 --> 01:13:03,730
+عشوائي، إنه هل هيكون غالبية الـ«جينوم» متشابه؟لكن
+
+763
+01:13:03,730 --> 01:13:08,110
+في اختلاف في 1% أو 2% يعني الغالب هو المتشابه
+
+764
+01:13:08,110 --> 01:13:11,690
+والاختلاف هو اللي هيكون أقل لإنه في الـ «سلايد»
+
+765
+01:13:11,690 --> 01:13:15,670
+يعني برضه في التعليق الـ «Catching» تحت الصورة
+
+766
+01:13:15,670 --> 01:13:20,630
+كاتب إن الـ «سيكوينس» من DNA من مجموعة من الشخصيات
+
+767
+01:13:20,630 --> 01:13:24,130
+هي متشابهة لكنها ليست متشابهة يعني الغالب هو اللي
+
+768
+01:13:24,130 --> 01:13:27,890
+يكون متشابه – هذه النقطة اللي بتحكيها طبعا يعني
+
+769
+01:13:27,890 --> 01:13:37,330
+هذا لتسهيل عملية دراسةالقطع المحددة يعني أنا بصير
+
+770
+01:13:37,330 --> 01:13:41,710
+مثلًا الواحد عنده hemoglobinopathy بصير بيدركز على
+
+771
+01:13:41,710 --> 01:13:46,350
+الـ الـ hemoglobin genes الـ Alpha والـ Beta
+
+772
+01:13:46,350 --> 01:13:51,530
+chains فبروح على الـ DNA تبعهم بحاول أسوي sequence
+
+773
+01:13:51,530 --> 01:13:55,850
+و بشوف مين إنسان مريض مين إنسان طبيعي بس حتى
+
+774
+01:13:55,850 --> 01:14:03,230
+أحيانًا الطبيعيين لما أنا أدرس الـ الـبالفرق بين
+
+775
+01:14:03,230 --> 01:14:06,550
+الـ Reference Sequence اللي هي ما هو عشان أقدر
+
+776
+01:14:06,550 --> 01:14:11,830
+يعني الـ Reference Sequence بالأخير بيمثل شو بده
+
+777
+01:14:11,830 --> 01:14:16,490
+أسميه يعني خارطة الطريق عشان تعرف وان أنت موجود
+
+778
+01:14:16,490 --> 01:14:25,310
+شايف علي؟ ضمن كمية الـ DNA هذه فترتيب الأحرف هذولة
+
+779
+01:14:25,310 --> 01:14:32,730
+هو اللي يعني بيمثل أحيان كثيرة قليةبتمكننا للوصول
+
+780
+01:14:32,730 --> 01:14:36,810
+لهذا الموقع فما علي إلى إفادات بس الفكرة اللي بدك
+
+781
+01:14:36,810 --> 01:14:42,370
+تاخدها إنه مش كل إنسان ما عدا الـ Identical Twins
+
+782
+01:14:42,370 --> 01:14:50,710
+ماشي الـ Identical Twins أه اللي بيكونوا شخصين
+
+783
+01:14:50,710 --> 01:14:57,910
+Completely Exact أي شخصين آخرين غير ذلك لما تيجي
+
+784
+01:14:57,910 --> 01:15:02,250
+تقارن بين الـ DNA تبعهمبكون فيه اختلافات،
+
+785
+01:15:02,250 --> 01:15:06,990
+واختلافات أحيانًا مش مهمة، يعني مالهاش تأثير وظيفي
+
+786
+01:15:06,990 --> 01:15:11,670
+على الـ Protein، وأحيانًا بتكون زي الـ Deletion،
+
+787
+01:15:11,670 --> 01:15:16,230
+لو الـ Deletion لثلاثة، بكون مش مهم كتير، بس لما
+
+788
+01:15:16,230 --> 01:15:20,610
+يكون واحد ولا أثنين، بيسموه Frame Shift، يعني
+
+789
+01:15:20,610 --> 01:15:25,450
+بيخربطلك الترتيب كله، فبالتالي، بكون تأثيره شديد
+
+790
+01:15:25,450 --> 01:15:30,320
+كتير أحيانًا، راح ناخد أن الظواهر هذه،أنا ما نوقفش
+
+791
+01:15:30,320 --> 01:15:36,000
+كثير كثير، يعني فيه لأي قطعة الـ DNA لما تتكلم
+
+792
+01:15:36,000 --> 01:15:41,060
+على، يعني هو إحنا مش بناخد التسع مليارات وباجي،
+
+793
+01:15:41,060 --> 01:15:44,140
+بدي أقول واحد بالمية، إثنين بالمية، فرق ولا كده،
+
+794
+01:15:44,140 --> 01:15:47,980
+إحنا لما نيجي ندرس في الـ Genetics، بالأخير بدي
+
+795
+01:15:47,980 --> 01:15:51,720
+أاخد قطعة صغيرة، بدي أاخد القطعة اللي عند الـ
+
+796
+01:15:51,720 --> 01:15:55,910
+Protein اللي أنا مهتم فيه، اللي أنا بدرسهللظاهر
+
+797
+01:15:55,910 --> 01:15:58,610
+اللي عندي، يا عم واحد عنده Hemoglobinopathy بدي
+
+798
+01:15:58,610 --> 01:16:01,330
+تبقى الـ Hemoglobin ألف أو Beta Chain، بركز على
+
+799
+01:16:01,330 --> 01:16:06,310
+هذولة لما أنا آجي أدرس كظاهرة في Reference بتكون
+
+800
+01:16:06,310 --> 01:16:10,310
+برجع لقطع معينة بيعتبروها هي الـReference،
+
+801
+01:16:10,310 --> 01:16:14,450
+Sequence وبلاقي أن البشر لما أنا آجي أدرسهم في
+
+802
+01:16:14,450 --> 01:16:18,910
+الغالب راح يكون فيه أنواع مختلفة من الاختلافات ما
+
+803
+01:16:18,910 --> 01:16:23,230
+عدا إذا Identical Twin للـReference إذا هو فعلاً
+
+804
+01:16:23,640 --> 01:16:31,040
+قريبه تمامًا، راح يكون تمامًا مثله، ماشي في أسئلة،
+
+805
+01:16:31,040 --> 01:16:38,940
+أنا مضطر أوقف هنا ساعة قريبة العشرة أشوف
+
+806
+01:16:38,940 --> 01:16:49,320
+إذا نلحق، نتكلم، هنا يعني اللي عندنا
+
+807
+01:16:49,320 --> 01:16:57,300
+حوالي 22 زوج أتزاملوفي عندي الـ X والـ Y الزوج تبع
+
+808
+01:16:57,300 --> 01:17:03,860
+الـ Six Chromosomes فلمّا نيجي نشوف صورتهم، هدولة
+
+809
+01:17:03,860 --> 01:17:08,160
+اللي هي الـ Karyotype بكون هيك أحجام الخلايا وهذا
+
+810
+01:17:08,160 --> 01:17:11,500
+بحطه جسم الستين بعضها باخد الستين أكتر على الـ
+
+811
+01:17:11,500 --> 01:17:21,040
+Histones وأشياء أقل، فيعني هنا مقارنة بينعدد
+
+812
+01:17:21,040 --> 01:17:27,560
+الكروموزومات لحجم الكروموزومات و الـ… الـDensity
+
+813
+01:17:27,560 --> 01:17:35,280
+تبعات الجينة يعني الـ25 ألف جين يعني
+
+814
+01:17:35,280 --> 01:17:43,180
+هاي هنا ألفين جين يعني اللي هو الـChromosome 1فيه
+
+815
+01:17:43,180 --> 01:17:49,540
+حوالي ألفين جين والأشياء زي الـ X والـ Y الـ Y
+
+816
+01:17:49,540 --> 01:17:57,940
+قصدي والـ Fair 21 و 22 أصغر جينات، أصغر كروموزومات
+
+817
+01:17:57,940 --> 01:18:02,840
+يكون عدد الجينات، بس بالمتوسط بيحكوا فيه حوالي ألف
+
+818
+01:18:02,840 --> 01:18:04,840
+جين في كل كروموزوم
+
+819
+01:18:07,650 --> 01:18:11,750
+فيعني هو أنا بالأخير باعتبروها هذا الخط أنه
+
+820
+01:18:11,750 --> 01:18:18,610
+تقريبًا ست يعني سبعة تقريبًا جينات في كل Mega Base
+
+821
+01:18:18,610 --> 01:18:23,950
+اللي هو يعني مليون Base يعني كل مليون Nucleotide
+
+822
+01:18:23,950 --> 01:18:29,970
+بعطيني تقريبًا سبع جينات، هيك يعني بدا نخطأ فكل ما
+
+823
+01:18:29,970 --> 01:18:33,890
+كان حجم الـChromosome أكبر، عدد الجينات اللي فيه
+
+824
+01:18:33,890 --> 01:18:39,180
+أكبرهي أسئلة أنا مضطر أوقف بنكمل من هيك للمرة
+
+825
+01:18:39,180 --> 01:18:45,350
+الجايةتمام، دكتور، بس برضه يعني هو سؤال يعني هو
+
+826
+01:18:45,350 --> 01:18:50,170
+تقريبًا بيتعلق بالـslide اللي قبل دكتور أسمى إنه
+
+827
+01:18:50,170 --> 01:18:53,910
+الـsequence هو سؤال الـsequence هذا بيكون لشخص
+
+828
+01:18:53,910 --> 01:18:57,450
+جيناته مثالي تقريبًا يعني بيصنع البروتينات بشكل
+
+829
+01:18:57,450 --> 01:19:01,470
+سليم وأي اختلاف هيكون واحد بالمية ممكن الاختلاف
+
+830
+01:19:01,470 --> 01:19:05,570
+يكون طفرة أو تباين بالصفرات لأ لأ، حسنًا خلّينا ما
+
+831
+01:19:05,570 --> 01:19:10,720
+تدخلوش بهذا الموضوع مش مقصود هذا الكلامالفكرة كانت
+
+832
+01:19:10,720 --> 01:19:18,980
+تالية، لما بعد ما اكتشفنا الـ DNA وصرنا نعرف عنه،
+
+833
+01:19:18,980 --> 01:19:25,760
+الكلام قبل تقريبًا 30 سنة، ماشي، كيف بدنا نحاول
+
+834
+01:19:25,760 --> 01:19:30,980
+نفهم هذا الموضوع، على أي أساس بدي أنا أقيم عموم
+
+835
+01:19:30,980 --> 01:19:38,660
+البشر، فلما نسوي الـ Human Genome Project،كانت إنه
+
+836
+01:19:38,660 --> 01:19:43,380
+أخذوا بني آدم أي إنسان أنا بقولولي كان واحد يعني
+
+837
+01:19:43,380 --> 01:19:48,140
+حضرت course أو محاضر عن الموضوع هذا وذكر ليه إنه
+
+838
+01:19:48,140 --> 01:19:53,500
+هم هذا شخص مجهول يعني هم مش محددينه بس الأصل إنه
+
+839
+01:19:53,500 --> 01:19:57,720
+شخص طبيعي بس كل إنسان طبيعي إلا عنده أمراض وراثية
+
+840
+01:19:57,720 --> 01:20:01,720
+وإلا عنده مشاكل هو مش مش مش طبيعي هو يعني ما تقدر
+
+841
+01:20:01,720 --> 01:20:07,570
+تعتبره طبيعي فأخذوا بني آدم إيه؟ شخصوقروا كل شيء
+
+842
+01:20:07,570 --> 01:20:14,530
+عنده فلما قرناهن كلهن أصبحت هذه هي الـ Reference
+
+843
+01:20:14,530 --> 01:20:19,490
+Sequence فسير لما أنا آجي أتعامل مع أي حال بعدين
+
+844
+01:20:19,490 --> 01:20:24,730
+فسير أقول بالرجوع إلى حالة الشخص اللي هو الـ Human
+
+845
+01:20:24,730 --> 01:20:28,150
+Genome ما هو الـ Human Genome أنه أنا قريت تبعت
+
+846
+01:20:28,150 --> 01:20:32,870
+بني آدم تسع مليارات الـ Nucleotides وقريت شو هن
+
+847
+01:20:33,560 --> 01:20:36,780
+فهذه حتى محفوظة وموجودة يقول اللي بده يرجعلها
+
+848
+01:20:36,780 --> 01:20:42,120
+يرجعلها فلما أنا أجي أخد مثلا بعدين في هذه القطعة
+
+849
+01:20:42,120 --> 01:20:46,560
+الصغيرة اللي هى هدولة مثلا أربعين الـ Nucleotide
+
+850
+01:20:46,560 --> 01:20:54,640
+جبت الإنسان ألف في دراسة عيلة معينة نفترض فالشخص
+
+851
+01:20:54,640 --> 01:20:59,820
+الأول في العيلة والله طلع مطابق تماما لهذا المرجع
+
+852
+01:21:00,860 --> 01:21:05,320
+الشخص الثاني والثالث طلع فيه Single-neutralized
+
+853
+01:21:05,320 --> 01:21:10,160
+polymorphism أو Changes يعني في محل واحد فالشخص
+
+854
+01:21:10,160 --> 01:21:14,220
+الثاني والثالث والرابع الشخص الخامس الانهي هي
+
+855
+01:21:14,220 --> 01:21:21,100
+طريقة الـ Reporting يعني طريقة تقرير أو شو اللي
+
+856
+01:21:21,100 --> 01:21:26,240
+أنا راح اكتبه لما درست تبع الـ DNA تبع عائلة معينة
+
+857
+01:21:26,240 --> 01:21:33,020
+أو مجموعة معينة أو شخص معين فالآنالـ… يعني
+
+858
+01:21:33,020 --> 01:21:40,180
+الـReference لا يمثل الطبيعي بس يمثل المرجعية اللي
+
+859
+01:21:40,180 --> 01:21:47,260
+بدرسه الـGenetics وبدرسه الـ… الـ… يعني بدرسه
+
+860
+01:21:47,260 --> 01:21:51,420
+الموضوع هذا الـ… الـGenetics تبعت أي مرض، تبعت أي
+
+861
+01:21:51,420 --> 01:21:55,660
+عيلة، تبعت أي مشكلة، بيصيروا يقارنوا فيه، فهو
+
+862
+01:21:55,660 --> 01:22:01,680
+مرجعية لإنكيعني تحكي شو النتيجة في الدراسة اللي
+
+863
+01:22:01,680 --> 01:22:06,800
+انت القيتها فاهم عليك؟ فلا تمثل أنه بالضرورة
+
+864
+01:22:06,800 --> 01:22:11,180
+reference هو الطبيعي و individual one طبيعي واثنين
+
+865
+01:22:11,180 --> 01:22:15,600
+وثلاثة هم مريضين، لأ، في الغالب مش مريضين، بس هي
+
+866
+01:22:15,600 --> 01:22:20,610
+ظاهرة موجودةماشي ورح نحكي ليش مش بالضرورة يكون أنه
+
+867
+01:22:20,610 --> 01:22:24,090
+هذا يغير البروتين يعني ممكن individuals one و two
+
+868
+01:22:24,090 --> 01:22:27,770
+و three و four يطلع نفس البروتين مايكونش فرق بينهم
+
+869
+01:22:27,770 --> 01:22:37,270
+حتى لو ال DNA اختلف واضح؟
+
+870
+01:22:37,270 --> 01:22:41,790
+أتمنى أنه يكون الأمر واضح إذا في حد عنده سؤال تمام
+
+871
+01:22:42,630 --> 01:22:47,770
+أنا عندى ساعة عشرة محاضرة ثانية أو شغل فنلتقي يوم
+
+872
+01:22:47,770 --> 01:22:51,450
+الأحد إن شاء الله الساعة تمانية ونصف ونفدى من هنا
+
+873
+01:22:51,450 --> 01:22:59,530
+واللي عنده أي سؤال إذا بالـ WhatsApp فى إشي أو إذا
+
+874
+01:22:59,530 --> 01:23:03,910
+group بيكون موجودة و بتقدر تدخلنى فيهم ممكن من هنا
+
+875
+01:23:03,910 --> 01:23:08,160
+إلى ذلك الوقت نتكلم على هذاطلعنا من المعدين
+
+876
+01:23:08,160 --> 01:23:11,980
+المندوين أسف إنه يعملوا group WhatsApp و تكون أنت
+
+877
+01:23:11,980 --> 01:23:17,400
+موجود فيه مافي مشكلة، مافي مشكلة إذا .. إذا في أي
+
+878
+01:23:17,400 --> 01:23:21,780
+أسئلة مش واضح نتكلم عليه إن شاء الله بإذن الله
+
+879
+01:23:21,780 --> 01:23:24,740
+تعالى أهلين، أهلين، يالا السلام عليكم يعطيك
+
+880
+01:23:24,740 --> 01:23:27,320
+العافية دكتور الله يرضي عليكم، نشوفكم على خير إن
+
+881
+01:23:27,320 --> 01:23:30,580
+شاء الله مع السلامة مع السلامة
+
+882
+01:23:34,350 --> 01:23:37,330
+أعطيكم العافية برضه دكاترا في العاية التالية
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Tl5zcdiL4_o_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Tl5zcdiL4_o_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..27ab8c7bb48924e437caa05f41e295aa632b0209
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Tl5zcdiL4_o_raw.json
@@ -0,0 +1 @@
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"word": " لأي", "probability": 0.90771484375}, {"start": 397.26, "end": 397.92, "word": " بروتين", "probability": 0.87158203125}, {"start": 397.92, "end": 398.94, "word": " ولمّا", "probability": 0.72650146484375}, {"start": 398.94, "end": 399.4, "word": " بعدين", "probability": 0.652587890625}, {"start": 399.4, "end": 400.0, "word": " نتكلم", "probability": 0.97802734375}, {"start": 400.0, "end": 400.24, "word": " على", "probability": 0.86474609375}, {"start": 400.24, "end": 400.46, "word": " أن", "probability": 0.515625}, {"start": 400.46, "end": 400.98, "word": " مثلا", "probability": 0.780517578125}, {"start": 400.98, "end": 402.02, "word": " الـ", "probability": 0.92529296875}, {"start": 402.02, "end": 402.72, "word": " Hemoglobin", "probability": 0.8541666666666666}, {"start": 402.72, "end": 403.4, "word": " بروتين", "probability": 0.8768310546875}, {"start": 403.4, "end": 404.56, "word": " عبارة", "probability": 0.88134765625}, {"start": 404.56, "end": 404.9, "word": " عن", "probability": 0.97314453125}, {"start": 404.9, "end": 405.6, "word": " حقيقة", "probability": 0.93310546875}, {"start": 405.6, "end": 406.5, "word": " أربع", "probability": 0.8069661458333334}, {"start": 406.5, "end": 407.68, "word": " Polypeptides", "probability": 0.76708984375}], "temperature": 1.0}, {"id": 16, "seek": 43677, "start": 408.53, "end": 436.77, "text": "أربع قطع، Two Alphas وTwo Betas كل واحد منهم Alpha أو Beta هي عبارة عن بوليفيد بتاع الـ Chain واحد معين وفي نصه فيه Hemomolecule الـ Hemomolecule اللي فيه الحديد اللي بيمسك الـ Oxygen فلما نتكلم على الـ Structure تبع الـ Total Hemoglobin Protein بنقول إنه عبارة عن Four", "tokens": [10721, 25513, 3615, 12174, 9566, 3615, 12399, 4453, 967, 7485, 4032, 33594, 6279, 296, 28242, 36764, 24401, 9154, 16095, 20588, 34051, 33286, 39896, 6225, 3555, 9640, 3660, 18871, 4724, 12610, 1829, 5172, 25708, 39894, 45761, 2423, 39184, 33252, 36764, 24401, 20449, 9957, 4032, 41185, 8717, 9381, 3224, 8978, 3224, 18568, 298, 4812, 66, 2271, 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"probability": 0.979248046875}, {"start": 425.39, "end": 425.79, "word": " بيمسك", "probability": 0.7998046875}, {"start": 425.79, "end": 425.95, "word": " الـ", "probability": 0.818359375}, {"start": 425.95, "end": 426.37, "word": " Oxygen", "probability": 0.94677734375}, {"start": 426.37, "end": 427.57, "word": " فلما", "probability": 0.8229166666666666}, {"start": 427.57, "end": 429.09, "word": " نتكلم", "probability": 0.9869384765625}, {"start": 429.09, "end": 429.43, "word": " على", "probability": 0.826171875}, {"start": 429.43, "end": 429.61, "word": " الـ", "probability": 0.84619140625}, {"start": 429.61, "end": 430.09, "word": " Structure", "probability": 0.748046875}, {"start": 430.09, "end": 430.47, "word": " تبع", "probability": 0.8909505208333334}, {"start": 430.47, "end": 430.75, "word": " الـ", "probability": 0.928466796875}, {"start": 430.75, "end": 431.11, "word": " Total", "probability": 0.79638671875}, {"start": 431.11, "end": 432.05, "word": " Hemoglobin", "probability": 0.93603515625}, {"start": 432.05, "end": 433.55, "word": " Protein", "probability": 0.8681640625}, {"start": 433.55, "end": 434.87, "word": " بنقول", "probability": 0.857421875}, {"start": 434.87, "end": 435.59, "word": " إنه", "probability": 0.834228515625}, {"start": 435.59, "end": 436.01, "word": " عبارة", "probability": 0.987060546875}, {"start": 436.01, "end": 436.27, "word": " عن", "probability": 0.9951171875}, {"start": 436.27, "end": 436.77, "word": " Four", "probability": 0.5791015625}], "temperature": 1.0}, {"id": 17, "seek": 46546, "start": 438.68, "end": 465.46, "text": "وكل واحدة منها Globular «هيمو» و «جلوبين» «جلوبين» يعني كروي فالـ «هيمو» و «جلوبين» في أربع Polypeptide Chains Two Alphas و Two Betas فالآن يعني هذا كبروتين موجود في الجسم بتكون السر الأول فيه في الـ Primary Structure", "tokens": [2407, 28820, 36764, 24401, 3660, 9154, 11296, 5209, 996, 1040, 4657, 3224, 32640, 2407, 5933, 4032, 4657, 7435, 1211, 2407, 21292, 1863, 5933, 4657, 7435, 1211, 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Tertiary Structure نتيجة الحلقات بين الـ Amino Acids البعد عن بعض", "tokens": [6027, 20292, 31439, 2423, 39184, 2012, 2982, 5097, 3742, 13672, 1829, 39894, 30544, 9154, 11296, 46599, 22488, 29910, 23275, 12399, 39894, 3615, 28543, 9673, 2407, 11242, 45367, 20666, 39184, 5736, 822, 745, 2885, 8717, 31371, 7435, 3660, 2423, 39184, 20588, 6128, 1473, 16070, 39184, 33286, 25658, 770, 1240, 1385, 46599, 22488, 9957, 4724, 1829, 9381, 13546, 14739, 11296, 6564, 7317, 822, 745, 2885, 8717, 31371, 7435, 3660, 21542, 1211, 4587, 9307, 49374, 2423, 39184, 2012, 2982, 5097, 3742, 29739, 22488, 18871, 45030, 11242], "avg_logprob": -0.16173734959392322, "compression_ratio": 1.5784313725490196, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 466.05, "end": 466.39, "word": "اللي", "probability": 0.947998046875}, {"start": 466.39, "end": 466.81, "word": " هو", "probability": 0.9306640625}, {"start": 466.81, "end": 467.21, "word": " الـ", "probability": 0.965576171875}, {"start": 467.21, 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الـ… يعني هنا هذه التركيب الـ… الـ… أقولها، هذه مجموعة الفوسفات وهذه الـRibose وهنا بشبك فيه الـBase رقم واحد بعدين بيجي فوسفات، بيجي Ribose، بيجي الـBase رقم اثنين فوسفات، Ribose، الـBase رقم ثلاثة تيجي بهذا الترتيب الـ… بالنسبة لـ…", "tokens": [5172, 41185, 3224, 43242, 8315, 2423, 39184, 1260, 2423, 39184, 1260, 37495, 22653, 34105, 29538, 16712, 31747, 1829, 3555, 2423, 39184, 1260, 2423, 39184, 1260, 5551, 39648, 11296, 12399, 29538, 3714, 7435, 2304, 2407, 27884, 27188, 41779, 5172, 9307, 37037, 24192, 2423, 39184, 49, 897, 541, 37037, 8315, 4724, 8592, 3555, 4117, 8978, 3224, 2423, 39184, 33, 651, 12602, 4587, 2304, 36764, 24401, 39182, 9957, 4724, 1829, 7435, 1829, 6156, 41779, 5172, 9307, 12399, 4724, 1829, 7435, 1829, 38554, 541, 12399, 4724, 1829, 7435, 1829, 2423, 39184, 33, 651, 12602, 4587, 2304, 1975, 12984, 1863, 9957, 6156, 41779, 5172, 9307, 12399, 38554, 541, 12399, 2423, 39184, 33, 651, 12602, 4587, 2304, 38637, 1211, 5718, 104, 3660, 6055, 1829, 7435, 1829, 39627, 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Ribose،", "probability": 0.9632161458333334}, {"start": 1673.54, "end": 1673.86, "word": " الـBase", "probability": 0.9794921875}, {"start": 1673.86, "end": 1674.16, "word": " رقم", "probability": 0.98876953125}, {"start": 1674.16, "end": 1674.84, "word": " ثلاثة", "probability": 0.93056640625}, {"start": 1674.84, "end": 1675.64, "word": " تيجي", "probability": 0.83563232421875}, {"start": 1675.64, "end": 1676.08, "word": " بهذا", "probability": 0.977783203125}, {"start": 1676.08, "end": 1676.74, "word": " الترتيب", "probability": 0.86474609375}, {"start": 1676.74, "end": 1678.82, "word": " الـ…", "probability": 0.8938802083333334}, {"start": 1678.82, "end": 1679.72, "word": " بالنسبة", "probability": 0.997802734375}, {"start": 1679.72, "end": 1680.54, "word": " لـ…", "probability": 0.87548828125}], "temperature": 1.0}, {"id": 63, "seek": 169471, "start": 1680.77, "end": 1694.71, "text": "لما ناخد، نقيص على تركيبة الـ «ريبوز» إنه إذا بتاخدوا بالكيميا الحيوية، بتكون إنك أنت بتقدر", 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اللي بيسموه في الـ Karyotype من اللي بيسموه عند دراسة الكرمозومات تبع الإنسان بشكل كبير فاحنا ناخد على شكل واحدة هذه الدراسات، بيكون", "tokens": [3555, 9640, 3615, 995, 14111, 13412, 28820, 20666, 10721, 9778, 13546, 37495, 22653, 3714, 43020, 7251, 30544, 15844, 13412, 28820, 11331, 36150, 23032, 2407, 26895, 37037, 4117, 15730, 4032, 19528, 11703, 995, 8717, 10721, 9778, 24192, 4724, 8592, 28820, 13672, 1829, 31439, 43242, 13672, 1829, 4724, 1829, 38251, 2407, 3224, 8978, 2423, 39184, 591, 822, 13108, 9154, 13672, 1829, 4724, 1829, 38251, 2407, 3224, 43242, 11778, 23557, 3794, 3660, 33251, 2288, 2304, 3434, 20498, 9307, 6055, 3555, 3615, 33688, 1863, 3794, 7649, 4724, 8592, 28820, 9122, 3555, 13546, 6156, 39319, 8315, 8717, 47283, 3215, 15844, 13412, 28820, 36764, 24401, 3660, 29538, 32748, 23557, 3794, 9307, 12399, 4724, 1829, 30544], "avg_logprob": -0.2430397696115754, "compression_ratio": 1.7636363636363637, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 2993.83, 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3003.09, "end": 3005.53, "word": " نأخذه", "probability": 0.61163330078125}, {"start": 3005.53, "end": 3005.97, "word": " بشكل", "probability": 0.931640625}, {"start": 3005.97, "end": 3006.19, "word": " اللي", "probability": 0.97119140625}, {"start": 3006.19, "end": 3006.39, "word": " هو", "probability": 0.873046875}, {"start": 3006.39, "end": 3006.67, "word": " عند", "probability": 0.94921875}, {"start": 3006.67, "end": 3007.07, "word": " اللي", "probability": 0.748046875}, {"start": 3007.07, "end": 3007.93, "word": " بيسموه", "probability": 0.916015625}, {"start": 3007.93, "end": 3008.95, "word": " في", "probability": 0.448486328125}, {"start": 3008.95, "end": 3009.09, "word": " الـ", "probability": 0.927734375}, {"start": 3009.09, "end": 3010.01, "word": " Karyotype", "probability": 0.7318115234375}, {"start": 3010.01, "end": 3010.47, "word": " من", "probability": 0.21826171875}, {"start": 3010.47, "end": 3010.57, "word": " اللي", "probability": 0.989013671875}, {"start": 3010.57, 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3427.36, "end": 3427.96, "word": " Bases", "probability": 0.777099609375}, {"start": 3427.96, "end": 3429.52, "word": " الـNitrogen", "probability": 0.9138671875}, {"start": 3429.52, "end": 3429.88, "word": " Bases", "probability": 0.91015625}, {"start": 3429.88, "end": 3430.1, "word": " دو", "probability": 0.5206298828125}, {"start": 3430.1, "end": 3430.54, "word": " بالأخير", "probability": 0.7801513671875}, {"start": 3430.54, "end": 3430.74, "word": " هم", "probability": 0.858154296875}, {"start": 3430.74, "end": 3430.86, "word": " اللي", "probability": 0.99365234375}, {"start": 3430.86, "end": 3431.42, "word": " بتحكموا", "probability": 0.9085693359375}, {"start": 3431.42, "end": 3432.02, "word": " بالبروتر", "probability": 0.8223876953125}], "temperature": 1.0}, {"id": 128, "seek": 345022, "start": 3432.58, "end": 3450.22, "text": "فلما أنا آجي أدرس مثلا نفترض أنه بدي أدرس الـ gene تبع الـ Alpha chain تبع الـ hemoglobin فبروح بشوف إنسان مثلا الشخص الأول", "tokens": [5172, 1211, 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{"start": 3444.94, "end": 3446.52, "word": " فبروح", "probability": 0.9171142578125}, {"start": 3446.52, "end": 3447.72, "word": " بشوف", "probability": 0.9290364583333334}, {"start": 3447.72, "end": 3448.16, "word": " إنسان", "probability": 0.9329427083333334}, {"start": 3448.16, "end": 3448.58, "word": " مثلا", "probability": 0.984375}, {"start": 3448.58, "end": 3449.68, "word": " الشخص", "probability": 0.95849609375}, {"start": 3449.68, "end": 3450.22, "word": " الأول", "probability": 0.995361328125}], "temperature": 1.0}, {"id": 129, "seek": 347922, "start": 3451.52, "end": 3479.22, "text": "مثلاً اللي هو «باعتبره أنه كان طبيعي» «والإنسان اللي ماعلوش مشكلة» «وباعتبره طبيعي» يعني أحيانًا الـReference Sequence هذا ممكن يكون لإنسان مريض أو إنسان طبيعي بس هو الأول اللي اعتمدنا عليه في دراسة هذا القطعة من الـDNA يعني هذه الفكرة الأولى فإذا أنا الإنسان الأول كان بهذا الشكل وبعدين", "tokens": [2304, 12984, 15040, 14111, 13672, 1829, 31439, 4657, 3555, 995, 34268, 26890, 3224, 14739, 3224, 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طبيعي»", "probability": 0.99560546875}, {"start": 3459.76, "end": 3460.14, "word": " يعني", "probability": 0.825927734375}, {"start": 3460.14, "end": 3460.68, "word": " أحيانًا", "probability": 0.9344889322916666}, {"start": 3460.68, "end": 3461.46, "word": " الـReference", "probability": 0.81829833984375}, {"start": 3461.46, "end": 3462.38, "word": " Sequence", "probability": 0.92041015625}, {"start": 3462.38, "end": 3462.68, "word": " هذا", "probability": 0.72216796875}, {"start": 3462.68, "end": 3463.36, "word": " ممكن", "probability": 0.91796875}, {"start": 3463.36, "end": 3463.64, "word": " يكون", "probability": 0.990478515625}, {"start": 3463.64, "end": 3464.18, "word": " لإنسان", "probability": 0.948828125}, {"start": 3464.18, "end": 3464.56, "word": " مريض", "probability": 0.9964192708333334}, {"start": 3464.56, "end": 3464.72, "word": " أو", "probability": 0.9970703125}, {"start": 3464.72, "end": 3465.08, "word": " إنسان", "probability": 0.9189453125}, {"start": 3465.08, 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"word": " الـDNA", "probability": 0.9647216796875}, {"start": 3470.88, "end": 3471.56, "word": " يعني", "probability": 0.88427734375}, {"start": 3471.56, "end": 3471.7, "word": " هذه", "probability": 0.3271484375}, {"start": 3471.7, "end": 3472.08, "word": " الفكرة", "probability": 0.9947916666666666}, {"start": 3472.08, "end": 3472.66, "word": " الأولى", "probability": 0.9573567708333334}, {"start": 3472.66, "end": 3474.02, "word": " فإذا", "probability": 0.8888346354166666}, {"start": 3474.02, "end": 3474.28, "word": " أنا", "probability": 0.9638671875}, {"start": 3474.28, "end": 3474.9, "word": " الإنسان", "probability": 0.9952392578125}, {"start": 3474.9, "end": 3475.4, "word": " الأول", "probability": 0.994140625}, {"start": 3475.4, "end": 3476.08, "word": " كان", "probability": 0.99267578125}, {"start": 3476.08, "end": 3477.34, "word": " بهذا", "probability": 0.94921875}, {"start": 3477.34, "end": 3477.84, "word": " الشكل", "probability": 0.99267578125}, {"start": 3477.84, "end": 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"end": 3485.85, "word": " بقدر", "probability": 0.7728678385416666}, {"start": 3485.85, "end": 3486.15, "word": " أظن", "probability": 0.837890625}, {"start": 3486.15, "end": 3487.17, "word": " أدرس،", "probability": 0.8791015625}, {"start": 3487.17, "end": 3487.77, "word": " بشوف", "probability": 0.9915364583333334}, {"start": 3487.77, "end": 3488.29, "word": " شو", "probability": 0.910400390625}, {"start": 3488.29, "end": 3489.45, "word": " الاختلافات", "probability": 0.865478515625}, {"start": 3489.45, "end": 3490.95, "word": " وبتكون", "probability": 0.77850341796875}, {"start": 3490.95, "end": 3491.71, "word": " إنه", "probability": 0.761962890625}, {"start": 3491.71, "end": 3492.29, "word": " أنا", "probability": 0.9248046875}, {"start": 3492.29, "end": 3492.81, "word": " في", "probability": 0.919921875}, {"start": 3492.81, "end": 3493.33, "word": " الأصل", "probability": 0.94677734375}, {"start": 3493.33, "end": 3493.65, "word": " في", "probability": 0.5380859375}, {"start": 3493.65, "end": 3494.25, "word": " الغالب", "probability": 0.989013671875}, {"start": 3494.25, "end": 3496.71, "word": " العمود", "probability": 0.8766276041666666}, {"start": 3496.71, "end": 3497.23, "word": " الفقري", "probability": 0.9679361979166666}, {"start": 3497.23, "end": 3497.53, "word": " تبع", "probability": 0.9567057291666666}, {"start": 3497.53, "end": 3498.15, "word": " ترتيب", "probability": 0.9700927734375}, {"start": 3498.15, "end": 3498.79, "word": " الـ", "probability": 0.957275390625}, {"start": 3498.79, "end": 3500.95, "word": " «جين»", "probability": 0.73223876953125}, {"start": 3500.95, "end": 3501.39, "word": " هذا", "probability": 0.89599609375}, {"start": 3501.39, "end": 3502.23, "word": " لهذا", "probability": 0.84716796875}, {"start": 3502.23, "end": 3502.99, "word": " البروتين", "probability": 0.8931884765625}, {"start": 3502.99, "end": 3504.59, "word": " بكون", "probability": 0.722900390625}, {"start": 3504.59, "end": 3505.55, "word": " بشكل", "probability": 0.9832356770833334}, {"start": 3505.55, "end": 3506.49, "word": " معين،", "probability": 0.9025065104166666}, {"start": 3506.49, "end": 3507.23, "word": " فبعتبره", "probability": 0.88232421875}, {"start": 3507.23, "end": 3508.05, "word": " الأساسي", "probability": 0.966064453125}], "temperature": 1.0}, {"id": 131, "seek": 353297, "start": 3508.13, "end": 3532.97, "text": "لما أجي أسوي report لـ الـ reference sequence هذا هو تبع أول إنسان درسناه أو أول إنسان سويتله sequence على افتراض أنه إنسان طبيعي فلما أجي أجيب لإنسان ثاني وهنا أنا سويت لأربعة غيره لاقيت أنه", "tokens": [1211, 15042, 5551, 7435, 1829, 5551, 3794, 45865, 2275, 5296, 39184, 2423, 39184, 6408, 8310, 23758, 31439, 6055, 3555, 3615, 5551, 12610, 36145, 3794, 7649, 11778, 2288, 3794, 8315, 3224, 34051, 5551, 12610, 36145, 3794, 7649, 8608, 2407, 36081, 43761, 8310, 15844, 1975, 5172, 2655, 2288, 46958, 14739, 3224, 36145, 3794, 7649, 23032, 21292, 3615, 1829, 6156, 1211, 15042, 5551, 7435, 1829, 5551, 7435, 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بدك تتخيل مثلًا", "tokens": [1211, 10721, 12399, 19446, 4724, 36081, 2304, 6055, 5016, 2407, 26895, 3224, 30731, 6531, 12432, 34051, 6531, 24278, 6156, 3224, 24192, 37495, 9566, 1829, 8315, 2423, 26890, 35473, 9957, 12399, 6156, 21292, 34268, 26890, 2407, 3224, 8774, 12, 66, 8616, 37037, 15730, 5551, 5016, 1829, 7649, 14111, 995, 3714, 16095, 8978, 6225, 42213, 10632, 16712, 5016, 24793, 8978, 6055, 4117, 2407, 9957, 2423, 26890, 35473, 9957, 37495, 22653, 12399, 5296, 10721, 37495, 22653, 12399, 47525, 4117, 6055, 2655, 9778, 26895, 50113, 1211, 14111, 995], "avg_logprob": -0.23272058402790743, "compression_ratio": 1.5315789473684212, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 3749.29, "end": 3750.09, "word": "لأ،", "probability": 0.85009765625}, {"start": 3750.09, "end": 3750.29, "word": " ما", "probability": 0.9072265625}, {"start": 3750.29, "end": 3751.35, "word": " بيتم", "probability": 0.7451171875}, {"start": 3751.35, "end": 3755.85, "word": " تحويله", 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{"start": 4987.04, "end": 4987.24, "word": " من", "probability": 0.869140625}, {"start": 4987.24, "end": 4988.16, "word": " المعدين", "probability": 0.5849609375}, {"start": 4988.16, "end": 4989.04, "word": " المندوين", "probability": 0.56884765625}, {"start": 4989.04, "end": 4989.56, "word": " أسف", "probability": 0.6996256510416666}, {"start": 4989.56, "end": 4989.98, "word": " إنه", "probability": 0.5701904296875}, {"start": 4989.98, "end": 4990.5, "word": " يعملوا", "probability": 0.9732666015625}, {"start": 4990.5, "end": 4990.76, "word": " group", "probability": 0.7666015625}, {"start": 4990.76, "end": 4991.22, "word": " WhatsApp", "probability": 0.1866455078125}, {"start": 4991.22, "end": 4991.5, "word": " و", "probability": 0.515625}, {"start": 4991.5, "end": 4991.76, "word": " تكون", "probability": 0.742431640625}, {"start": 4991.76, "end": 4991.98, "word": " أنت", "probability": 0.72412109375}, {"start": 4991.98, "end": 4992.4, "word": " موجود", "probability": 0.9728190104166666}, {"start": 4992.4, "end": 4992.9, "word": " فيه", "probability": 0.928955078125}, {"start": 4992.9, "end": 4993.52, "word": " مافي", "probability": 0.569091796875}, {"start": 4993.52, "end": 4994.16, "word": " مشكلة،", "probability": 0.81292724609375}, {"start": 4994.16, "end": 4994.5, "word": " مافي", "probability": 0.8515625}, {"start": 4994.5, "end": 4995.18, "word": " مشكلة", "probability": 0.9910481770833334}, {"start": 4995.18, "end": 4995.68, "word": " إذا", "probability": 0.7435302734375}, {"start": 4995.68, "end": 4995.9, "word": " ..", "probability": 0.371826171875}, {"start": 4995.9, "end": 4996.6, "word": " إذا", "probability": 0.965576171875}, {"start": 4996.6, "end": 4997.18, "word": " في", "probability": 0.68603515625}, {"start": 4997.18, "end": 4997.4, "word": " أي", "probability": 0.7060546875}, {"start": 4997.4, "end": 4997.8, "word": " أسئلة", "probability": 0.99267578125}, {"start": 4997.8, "end": 4998.32, "word": " مش", "probability": 0.374267578125}, {"start": 4998.32, "end": 4998.8, "word": " واضح", "probability": 0.9850260416666666}, {"start": 4998.8, "end": 4999.78, "word": " نتكلم", "probability": 0.8603515625}, {"start": 4999.78, "end": 5000.12, "word": " عليه", "probability": 0.94384765625}, {"start": 5000.12, "end": 5000.3, "word": " إن", "probability": 0.63525390625}, {"start": 5000.3, "end": 5000.4, "word": " شاء", "probability": 0.972412109375}, {"start": 5000.4, "end": 5000.66, "word": " الله", "probability": 0.953125}, {"start": 5000.66, "end": 5001.6, "word": " بإذن", "probability": 0.790771484375}, {"start": 5001.6, "end": 5001.78, "word": " الله", "probability": 0.92724609375}, {"start": 5001.78, "end": 5002.18, "word": " تعالى", "probability": 0.8649088541666666}, {"start": 5002.18, "end": 5002.7, "word": " أهلين،", "probability": 0.76552734375}, {"start": 5002.7, "end": 5003.08, "word": " أهلين،", "probability": 0.924609375}, {"start": 5003.08, "end": 5003.32, "word": " يالا", "probability": 0.55224609375}, {"start": 5003.32, "end": 5003.64, "word": " السلام", "probability": 0.871826171875}, {"start": 5003.64, "end": 5004.2, "word": " عليكم", "probability": 0.94580078125}, {"start": 5004.2, "end": 5004.74, "word": " يعطيك", "probability": 0.85760498046875}, {"start": 5004.74, "end": 5005.06, "word": " العافية", "probability": 0.8225911458333334}, {"start": 5005.06, "end": 5005.26, "word": " دكتور", "probability": 0.79974365234375}, {"start": 5005.26, "end": 5005.44, "word": " الله", "probability": 0.4755859375}, {"start": 5005.44, "end": 5005.76, "word": " يرضي", "probability": 0.828125}, {"start": 5005.76, "end": 5006.22, "word": " عليكم،", "probability": 0.8302408854166666}, {"start": 5006.22, "end": 5006.66, "word": " نشوفكم", "probability": 0.9730224609375}, {"start": 5006.66, "end": 5006.84, "word": " على", "probability": 0.98046875}, {"start": 5006.84, "end": 5007.16, "word": " خير", "probability": 0.990478515625}, {"start": 5007.16, "end": 5007.32, "word": " إن", "probability": 0.8388671875}, {"start": 5007.32, "end": 5007.48, "word": " شاء", "probability": 0.988037109375}, {"start": 5007.48, "end": 5007.78, "word": " الله", "probability": 0.95947265625}, {"start": 5007.78, "end": 5009.22, "word": " مع", "probability": 0.96240234375}, {"start": 5009.22, "end": 5009.82, "word": " السلامة", "probability": 0.8772786458333334}, {"start": 5009.82, "end": 5010.0, "word": " مع", "probability": 0.6884765625}, {"start": 5010.0, "end": 5010.58, "word": " السلامة", "probability": 0.9853515625}], "temperature": 1.0}, {"id": 189, "seek": 501733, "start": 5014.35, "end": 5017.33, "text": "أعطيكم العافية برضه دكاترا في العاية التالية", "tokens": [10721, 3615, 9566, 1829, 24793, 18863, 31845, 10632, 4724, 43042, 3224, 11778, 4117, 9307, 23557, 8978, 18863, 995, 10632, 16712, 6027, 10632], "avg_logprob": -0.4925271531809931, "compression_ratio": 1.1549295774647887, "no_speech_prob": 0.0, "words": [{"start": 5014.35, "end": 5014.83, "word": "أعطيكم", "probability": 0.729296875}, {"start": 5014.83, "end": 5015.13, "word": " العافية", "probability": 0.5537516276041666}, {"start": 5015.13, "end": 5015.35, "word": " برضه", "probability": 0.8896484375}, {"start": 5015.35, "end": 5016.01, "word": " دكاترا", "probability": 0.71954345703125}, {"start": 5016.01, "end": 5016.71, "word": " في", "probability": 0.5}, {"start": 5016.71, "end": 5016.97, "word": " العاية", "probability": 0.3494466145833333}, {"start": 5016.97, "end": 5017.33, "word": " التالية", "probability": 0.919921875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 5018.087625, "duration_after_vad": 4905.9965937500165}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Y-q_VMv635w_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Y-q_VMv635w_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..abba21d57b33e7e9c070daa5e1d1ba49829a513e
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Y-q_VMv635w_postprocess.srt
@@ -0,0 +1,3308 @@
+1
+00:00:00,000 --> 00:00:04,820
+الذين يتعاملون بـ Minor Trauma والدي والدته ليس
+
+2
+00:00:04,820 --> 00:00:12,620
+لديه مشكلة برده طبعا يعني اللي لما نكون عندنا اشي
+
+3
+00:00:12,620 --> 00:00:20,320
+بنقوله يعني bleeding tendency فهي مشكلة في ال
+
+4
+00:00:20,320 --> 00:00:27,280
+bleeding disorder ايه بنسميها او problem with
+
+5
+00:00:27,280 --> 00:00:32,840
+hemostasisالـ Hemostasis يعني اللي هي طريقة
+
+6
+00:00:32,840 --> 00:00:37,280
+استجابة الجهاز الدوري الـ Cardiovascular System
+
+7
+00:00:37,280 --> 00:00:44,820
+لموضوع الـ Injury موضوع حدوث تمزح في الأوعي
+
+8
+00:00:44,820 --> 00:00:49,500
+الدموية في حياته الدم بيصير يطلع فعنا نوعين من الـ
+
+9
+00:00:49,500 --> 00:00:53,820
+Hemostasis فيه Primary Hemostasis وفيه Secondary
+
+10
+00:00:53,820 --> 00:01:00,430
+Hemostasis الـ Primary اللي بيشتغل أولا مباشرةماشي
+
+11
+00:01:00,430 --> 00:01:06,490
+وبكون واحدة من فنتين الـ platelets أو الـ blood
+
+12
+00:01:06,490 --> 00:01:11,110
+vessel response فهدولة بيسموها primary hemostasis
+
+13
+00:01:11,110 --> 00:01:17,850
+ال secondary hemostasis اللي هم نتيجة شغل ال
+
+14
+00:01:17,850 --> 00:01:22,430
+calculation factorفي عندنا الـ Extrinsic Pathway و
+
+15
+00:01:22,430 --> 00:01:25,810
+Intrinsic Pathway وCommon Pathway في الأخير
+
+16
+00:01:25,810 --> 00:01:29,750
+الفيبرينوجين بتحول لفيبرين بأعمل Clot بسكر الـ
+
+17
+00:01:29,750 --> 00:01:33,810
+Blood اللي إنجلت هدولة الـ Primary وSecondary
+
+18
+00:01:33,810 --> 00:01:43,190
+Homostasis ليش حطولكم النقاط هذه دايما سامعيني
+
+19
+00:01:43,190 --> 00:01:46,930
+فاهميني معاي الشباب والكل
+
+20
+00:01:51,290 --> 00:01:56,070
+- Hi كريم، معاك؟ ‏- مرحبًا يا أختي واصلي ‏- طيب،
+
+21
+00:01:56,070 --> 00:02:01,850
+الآن كيف نفرق الـ Primary وSecondary Hemostasis؟ ‏
+
+22
+00:02:01,850 --> 00:02:04,910
+- هذه نقطة بالـ Hematology، المفروض تاخدوها بعدها
+
+23
+00:02:04,910 --> 00:02:10,630
+‏- لدينا أربع Characteristics نفرقها ‏- هل هي
+
+24
+00:02:10,630 --> 00:02:16,910
+Coagulation Factor Problem ‏- ولا الـ
+
+25
+00:02:16,910 --> 00:02:21,950
+Primaryيعني الـ Coagulation Factor و لا الـ Place
+
+26
+00:02:21,950 --> 00:02:25,130
+to Blood Vessel Response Problem الـ Primary و لا
+
+27
+00:02:25,130 --> 00:02:29,210
+الـ Secondary الـ Primary أول شيء بنقوله
+
+28
+00:02:29,210 --> 00:02:34,270
+Superficial يعني عالجين على الإسنان لما واحد يفرش
+
+29
+00:02:34,270 --> 00:02:39,310
+إسنانه لما يكون إشي بيكون سطحي الـ Coagulation
+
+30
+00:02:39,310 --> 00:02:43,930
+Factor Problem بيكون Deep يعني زي هيك في الـ Joint
+
+31
+00:02:43,930 --> 00:02:48,070
+لما يقولك إنه في عنده Joint Problem Joint Swelling
+
+32
+00:02:48,660 --> 00:02:51,720
+وBleeding in the joints هذه بتقول Coagulation
+
+33
+00:02:51,720 --> 00:02:58,120
+Factor هاي واحدة الشغل الثاني الـ Bleeding بعد ال
+
+34
+00:02:58,120 --> 00:03:03,560
+trauma في حالة الـ Primary Hemostasis بيكون
+
+35
+00:03:03,560 --> 00:03:07,460
+Immediate لأنه Immediate الـ Primary يعني لو واحد
+
+36
+00:03:07,460 --> 00:03:11,060
+يكون عنده Platelet ولا عنده Blood Vessel Response
+
+37
+00:03:11,060 --> 00:03:19,190
+Problem بتلاقي مثلا بنجرح على طول بنزلوإذا سكرت
+
+38
+00:03:19,190 --> 00:03:22,850
+عليها ومنعت النزف وعطيت مجال للـ Coagulation
+
+39
+00:03:22,850 --> 00:03:29,650
+Factor يشتغله في الحالة هذه لما تسكر على الجرح لما
+
+40
+00:03:29,650 --> 00:03:33,490
+تشيل إيدك بعدين النزف بوقف، هذا بالـ Primary
+
+41
+00:03:33,490 --> 00:03:38,090
+Hemostasis السبب إن الـ Coagulation Factor كويسة
+
+42
+00:03:38,090 --> 00:03:45,030
+بينما الـ Primary Hemostasis بيكون بالأول الـ
+
+43
+00:03:45,030 --> 00:03:51,450
+Coagulation Factorماشي يعني كتير قصص أشهر واحد كان
+
+44
+00:03:51,450 --> 00:03:56,370
+عنده Hemophilia لـ Coagulation Factor Problem ابن
+
+45
+00:03:56,370 --> 00:04:00,390
+قيصر روسيا كانت بالتورة البلشفية كان عنده
+
+46
+00:04:00,390 --> 00:04:07,730
+Hemophilia هو نفس هذه القصة طفل ذكر كان يقع مثلًا
+
+47
+00:04:07,730 --> 00:04:13,010
+هو يلعب مجرد ما يقع مايكون فيه إشي يعني يكون زي زي
+
+48
+00:04:13,010 --> 00:04:18,660
+غيرهبس بعد 6 ساعات، 8 ساعات، 10 ساعات تصير يبين
+
+49
+00:04:18,660 --> 00:04:23,800
+Big Hematoma فالـ onset of bleeding after trauma
+
+50
+00:04:23,800 --> 00:04:29,040
+is delayed for secondary hemostasis ولمّا تيجي
+
+51
+00:04:29,040 --> 00:04:35,580
+تضغط على المحل النزف وتضغط لك ربع ساعة، تلت ساعة،
+
+52
+00:04:35,580 --> 00:04:41,600
+نص ساعة، لما تشيل إيدك، لأ النزف برجع، ما هو وقته
+
+53
+00:04:42,500 --> 00:04:47,600
+فهذه كلها secondary hemostasis problems من ناحية
+
+54
+00:04:47,600 --> 00:04:54,300
+الأخيرة، اللي هي مبدأ إنه in general إذا familial
+
+55
+00:04:54,300 --> 00:04:59,760
+أو genetic الـprimary hemostasis problems بتكون
+
+56
+00:04:59,760 --> 00:05:05,660
+autosomal dominant زي «بومبلبراند» disease والجروب
+
+57
+00:05:05,660 --> 00:05:10,420
+تبعتها هذه الـhemophilias، فيهم hemophilia A وB
+
+58
+00:05:10,940 --> 00:05:21,380
+بتكون Recessive X-linked Recessive فالسيناريو
+
+59
+00:05:21,380 --> 00:05:26,200
+اللي حاطينه بالأول طفل Male وعنده شكله Secondary
+
+60
+00:05:26,200 --> 00:05:31,700
+Hemostasis Problem وهي كلها ماشي مؤشر على
+
+61
+00:05:31,700 --> 00:05:35,810
+Hemophiliaطبعاً الـ Hemophilia فيه Hemophilia A و
+
+62
+00:05:35,810 --> 00:05:39,830
+Hemophilia B الـ Hemophilia A اللي هو الـ Factor 8
+
+63
+00:05:39,830 --> 00:05:43,830
+Deficiency Hemophilia B اللي هي Factor 9 اللي
+
+64
+00:05:43,830 --> 00:05:48,550
+بيسموها Christmas Disease اللي هي اسم تاني كل هذه
+
+65
+00:05:48,550 --> 00:05:53,650
+المعلومات هيك بتيجي من الأول يعني إنسان أو طفل أو
+
+66
+00:05:53,650 --> 00:06:00,050
+ذكر عنده Hemophilia A هاي الكلام اللي بيبقوا لكي
+
+67
+00:06:00,050 --> 00:06:02,670
+يعني الآن
+
+68
+00:06:04,750 --> 00:06:08,530
+الـ evaluation shows that the patient has
+
+69
+00:06:08,530 --> 00:06:12,710
+inherited disorders and that one of his parents is
+
+70
+00:06:12,710 --> 00:06:19,110
+a genetic carrier طبعا يعني هنا هاي لو كان
+
+71
+00:06:19,110 --> 00:06:26,510
+autosomal recessive ما بتثبت كان لازم يكون both
+
+72
+00:06:26,510 --> 00:06:32,650
+his parents are recessive are carriers ماشيفهذه
+
+73
+00:06:32,650 --> 00:06:36,570
+إلا تكون X-linked recessive والـ Career بالـ
+
+74
+00:06:36,570 --> 00:06:45,790
+Parents هي الأم، ماشي؟ أسا عنده أخت who does not
+
+75
+00:06:45,790 --> 00:06:53,290
+have this condition is pregnant يعني أسا أخته يعني
+
+76
+00:06:53,290 --> 00:07:01,090
+الـ Hallmark دائما بنقول أو العلام المميزةللـ X
+
+77
+00:07:01,090 --> 00:07:08,790
+-linked recessive أن الطفل أو أخواله هما المصابين،
+
+78
+00:07:08,790 --> 00:07:16,630
+ماشي؟ فيعني إذا بدك تشوف إنسان إذا هو عنده زي
+
+79
+00:07:16,630 --> 00:07:21,130
+أخواله إذا ولدوا أخواله، هي typical X-linked
+
+80
+00:07:21,130 --> 00:07:30,200
+recessive فالآن الأخت حاملأخت المصاب ماشي هي اللي
+
+81
+00:07:30,200 --> 00:07:39,080
+جاي تسأل وهي ما بتعرف اللي ببطنها ولد ولا بنت ماشي
+
+82
+00:07:39,080 --> 00:07:43,100
+she asked about the risk of her child will be
+
+83
+00:07:43,100 --> 00:07:45,600
+affected which of the following is the best
+
+84
+00:07:45,600 --> 00:07:52,400
+estimate of this child will have the disease ماشي
+
+85
+00:07:52,400 --> 00:07:54,580
+الآن
+
+86
+00:07:57,040 --> 00:08:01,600
+يعني مبدأ في حل الأسئلة اللي زي هيك أو في التعامل
+
+87
+00:08:01,600 --> 00:08:07,880
+مع هذا السؤال لما يجيك من بني آدم ماشي، بنحطه على
+
+88
+00:08:07,880 --> 00:08:14,800
+طريقين اللي هم يا إما أنا بكون متأكد وعارف
+
+89
+00:08:14,800 --> 00:08:24,690
+وبالتالي بعطي نسب محددة أو إذا مش متأكد، ماشيبدي
+
+90
+00:08:24,690 --> 00:08:29,870
+أسوي اللي بيسموهم الـ Conditional Probability واضح
+
+91
+00:08:29,870 --> 00:08:34,150
+يا كريم؟ الله يرضى عليك سامعيني؟ فاهميني إيه؟ شو
+
+92
+00:08:34,150 --> 00:08:39,550
+اللي بحكي؟ تمام يا دكتور، كل موجود يعني أو في عدد
+
+93
+00:08:39,550 --> 00:08:43,050
+موجود يعني غير كريم كمان موجودين أه، كتبين سبعة
+
+94
+00:08:43,050 --> 00:08:46,930
+اللي موجود أنا وياك يعني خمس غيره أنا فاهم إن اللي
+
+95
+00:08:46,930 --> 00:08:52,070
+طرح السؤال يكون فاهمهو الدكتورة «كارميل» هي اللي
+
+96
+00:08:52,070 --> 00:08:58,890
+طرحت السؤال يعني موجودة؟ صحيح صحيح صحيح موجودة
+
+97
+00:08:58,890 --> 00:09:04,730
+طيب، هسا كارميل كيف
+
+98
+00:09:04,730 --> 00:09:14,070
+بدنا نرد على إجابة السؤال هذا؟ الآن أنا الـ
+
+99
+00:09:14,070 --> 00:09:16,810
+Genotype يعني شو
+
+100
+00:09:19,740 --> 00:09:27,620
+الطفل المصاب أكيد عنده X-Chromosome مصاب الـ X
+
+101
+00:09:27,620 --> 00:09:32,160
+-Chromosome عنده مصاب الـ Y مافيش فيه إشي، صح؟
+
+102
+00:09:32,160 --> 00:09:38,600
+فبالتالي أخذوا من يا أبوه يا أمه الـ X هذا، ماشي؟
+
+103
+00:09:39,110 --> 00:09:46,450
+لو كان أبوه حكوا عنه مصاب يبقى ممكن أخذوا منه بس
+
+104
+00:09:46,450 --> 00:09:54,030
+الـ X بتكون من الـ يعني في الحالة هذه بتكون من
+
+105
+00:09:54,030 --> 00:10:01,750
+الأم والأم، أم الطفل هذا المصاب شو اسمه؟ هي الـ
+
+106
+00:10:01,750 --> 00:10:08,270
+Carrier لأنهم اثنينهم Healthy والطفل هذا هو المصاب
+
+107
+00:10:08,810 --> 00:10:13,810
+فكام بدأ أسوي الاحتمالات للسؤال اللي بيسألونياه
+
+108
+00:10:13,810 --> 00:10:20,390
+أخت الطفل هذا الأكبر منه صارت حامل وشافت أخوها
+
+109
+00:10:20,390 --> 00:10:26,670
+عنده مشكلة الـ hemophilia وإنه بنزل وإنه في عنده
+
+110
+00:10:26,670 --> 00:10:30,770
+مشاكل فخايفة على بطنها أو بدأت تتأكد بالنسبة
+
+111
+00:10:30,770 --> 00:10:41,860
+لبطنها شو احتمالاته ماشي ال .. ال ..هذه ما يسمى
+
+112
+00:10:41,860 --> 00:10:45,020
+النسب
+
+113
+00:10:45,020 --> 00:10:48,800
+اللي حاطينها عشر أو تمانية أو تسعة أو عشرين أنا
+
+114
+00:10:48,800 --> 00:10:53,980
+هذه خربطتني شوية هذه نسبة اللي جاوبوا هيك ماشي
+
+115
+00:10:53,980 --> 00:10:59,300
+مانعش أدخل بيها هو أنا بحطه النسبة صفر أو نص أو
+
+116
+00:10:59,300 --> 00:11:02,460
+ربع أو ثمن أو ستة واحدة أو ستاشر أو واحدة أو أثنين
+
+117
+00:11:02,460 --> 00:11:10,410
+وثلاثين كيف بدا نوقلها الآن السؤال الأولالأم اللي
+
+118
+00:11:10,410 --> 00:11:19,910
+هي البنت اللي هي حامل الآن اللي جاي تسأل «ماشي، شو
+
+119
+00:11:19,910 --> 00:11:25,270
+احتمالاتها بالنسبة للمرض هذا؟» «والحالي هذا؟» «مين
+
+120
+00:11:25,270 --> 00:11:34,190
+بيقدر يجاوب؟» قبل ما نشوف كيف تجاوبوها يا
+
+121
+00:11:34,190 --> 00:11:39,620
+إما هتكون health يا إما هتكون careerالنسبة كام لكل
+
+122
+00:11:39,620 --> 00:11:51,100
+واحدة؟ ربع طبعاً كيف ربع؟ نص المشهومة للأم الأصلية
+
+123
+00:11:51,100 --> 00:11:55,340
+career والأب healthy طيب ماني أعمل احتمالات،
+
+124
+00:11:55,340 --> 00:12:00,100
+هيطلع؟ أنا بحكي عن البنت اللي حامل اللي هي الآن لو
+
+125
+00:12:00,100 --> 00:12:05,500
+ترسم ال degree هي اللي جاية تسأل و عندها pregnancy
+
+126
+00:12:05,500 --> 00:12:11,550
+هي الأم المرأة الحاملهسا، شو احتمالات عندها الجين
+
+127
+00:12:11,550 --> 00:12:19,890
+المصاب؟ نص الإناث، نص بتكون نص، يعني نص الحالة، شو
+
+128
+00:12:19,890 --> 00:12:28,630
+اسمها؟ نص الحالة بكون فيها، عندها إصابة، آسف، نص
+
+129
+00:12:28,630 --> 00:12:33,250
+الحالات بتكون هي career ونص الحالات ممكن تكون
+
+130
+00:12:33,250 --> 00:12:40,820
+completely healthy، صح؟ تمام، صحيحكداش احتمالات أن
+
+131
+00:12:40,820 --> 00:12:50,480
+البطنها ولد ولا بنت؟ كمان نص بنص نص نص نص نص نص نص
+
+132
+00:12:50,480 --> 00:12:51,520
+نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص
+
+133
+00:12:51,520 --> 00:12:52,820
+نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص
+
+134
+00:12:52,820 --> 00:12:55,440
+نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص
+
+135
+00:12:55,440 --> 00:12:59,440
+نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص
+
+136
+00:12:59,440 --> 00:12:59,520
+نص نص نص نص نص نص نص نص
+
+137
+00:13:08,490 --> 00:13:16,030
+الحمل اللي بطن المرأة هذه أو البنت هذه نص نص إنها
+
+138
+00:13:16,030 --> 00:13:20,150
+تكون مصابة مصابة؟ ماعرفش احتمال إنها تكون مصابة
+
+139
+00:13:20,150 --> 00:13:28,470
+لأنه فيه احتمال نص إنه تكون carrier ماشي ونص تاني
+
+140
+00:13:28,470 --> 00:13:33,990
+إنه لأنه ما جاب حصيرة إنهالجوز المرة هذه أو الطفل
+
+141
+00:13:33,990 --> 00:13:40,950
+البنت هذه اللي يعني أخت المصاب ما جابه سيرة إنه
+
+142
+00:13:40,950 --> 00:13:47,550
+مصاب كمان صحيح فهسا لو كانت بنت فاحتمالية إنها
+
+143
+00:13:47,550 --> 00:13:56,070
+تكون مصاب صفر، صح؟ ولو طلع ولد، شو نسبت إنه يكون
+
+144
+00:13:56,070 --> 00:14:04,270
+مصاب؟أخد الـ X المصاب يعني نص برضه نص نص صح؟ صحيح
+
+145
+00:14:04,270 --> 00:14:13,210
+فإن انت تاخد إنه هي كالبنت
+
+146
+00:14:13,210 --> 00:14:19,470
+العامل هذه أخت الولد المصاب أول شيء هي احتمالها نص
+
+147
+00:14:19,470 --> 00:14:26,470
+إنه تكون هي career أي واحدة يعني عندها one copyوفي
+
+148
+00:14:26,470 --> 00:14:31,650
+احتمال نص أن يكون بنت وبالتالي ما في احتمال أن
+
+149
+00:14:31,650 --> 00:14:37,830
+يكون مصابر ولو كان ولد الاحتمال نص فنص بنص بنص بنص
+
+150
+00:14:37,830 --> 00:14:45,450
+بيطلع ثمن فالإجابة ثمن واضحة يعني هنا بدنا نطبق
+
+151
+00:14:45,450 --> 00:14:51,530
+إشي من كله conditional probability ماشي بقول ال
+
+152
+00:14:54,060 --> 00:15:00,900
+اللي هي المرأة الحامل هذه الأم اللي هنا بالحالة
+
+153
+00:15:00,900 --> 00:15:07,300
+الجيل الثاني أخت المصاب أول شيء في احتمال نص أنه
+
+154
+00:15:07,300 --> 00:15:13,100
+تكون career ونص أنها تكون normal وبعدين احتمال أنه
+
+155
+00:15:13,100 --> 00:15:19,940
+يكون ذكر ولا أنثىاللي باطنها، ما بنعرف لسه، لو
+
+156
+00:15:19,940 --> 00:15:25,080
+بعرف أنه ذكر بقول لأ الاحتمال بصير ربع، ماشي، لو
+
+157
+00:15:25,080 --> 00:15:29,260
+بعرف أنه ذكر، بس أنا ما بعرف أنه ذكر، فيمكن ذكر،
+
+158
+00:15:29,260 --> 00:15:32,660
+يمكن أنثى، لو هيك بتيجي بتسألني بالوجه، شو
+
+159
+00:15:32,660 --> 00:15:36,620
+احتمالية أنه يكون مصاب، بقول واحد على ثمانية،
+
+160
+00:15:36,620 --> 00:15:39,380
+واضحة الحال كيف؟ اللي بيسموها conditional
+
+161
+00:15:39,380 --> 00:15:46,370
+probability، يعني أنا بصير أحطحسب الشروط مجموع
+
+162
+00:15:46,370 --> 00:15:51,990
+الحلال مجموع النسب لازم يوصل واحد لأن كل
+
+163
+00:15:51,990 --> 00:15:58,630
+الاحتمالات راح تكون واحد، ماشي؟ فلما تيجيني امرأة
+
+164
+00:15:58,630 --> 00:16:03,230
+هيك زي هيك أخوها مصاب، هي حامل، هي مش عارفة شو
+
+165
+00:16:03,230 --> 00:16:06,830
+اللي عندها بتقوللي شو نسبة احتمالية ان البطن يطلع
+
+166
+00:16:06,830 --> 00:16:11,650
+مصاب، بقولها واحد ع ثمانين، هيك بدها تيجي، ماشي؟
+
+167
+00:16:12,100 --> 00:16:18,160
+فنشوف شو ال .. ال .. هنا هذا السؤال يعني فيه ناس
+
+168
+00:16:18,160 --> 00:16:23,060
+خربطوا في الرُبع فيه ناس حطوا نص فهسة هنا يعني هاي
+
+169
+00:16:23,060 --> 00:16:31,040
+برسمونا المثال اللي احنا اتكلمنا عنه ال .. هاي
+
+170
+00:16:31,040 --> 00:16:39,420
+الاجدود الأم أكيد لازم تكون career الأبو حكوا عنه
+
+171
+00:16:39,420 --> 00:16:49,370
+سليم مافي مشكلةالولد المصاب عنده جين مصاب ماشي في
+
+172
+00:16:49,370 --> 00:16:54,950
+الـ X و X-linked recessive فهيبين عليه فهذه البنت
+
+173
+00:16:54,950 --> 00:17:01,070
+هي اللي أجت تسأل وبتسأل على إنها عندها حمل وبدأت
+
+174
+00:17:01,070 --> 00:17:06,990
+تعرف قداش نسبته ففي احتمال النص إنها تكون Normal
+
+175
+00:17:06,990 --> 00:17:13,560
+ونص إنه يكون Carrierفي احتمال النُص أن يكون ولد
+
+176
+00:17:13,560 --> 00:17:22,440
+وفي احتمال نُص يكون بنت واحتمال الولد نُص كمان أنه
+
+177
+00:17:22,440 --> 00:17:28,020
+يطلع مصاب ونُص أنه يطلع طبيعي فالثلاث نُص بنُص
+
+178
+00:17:28,020 --> 00:17:31,800
+بنُص ويطلع واحد على ثمانية، هيك الإجابة الصحيحة في
+
+179
+00:17:31,800 --> 00:17:33,920
+أسئلة، إن شاء الله وضحكت هيك الأمور
+
+180
+00:17:37,880 --> 00:17:42,620
+يعني اللي حاطينها الـ B1 الـ Parents أو اللي هي
+
+181
+00:17:42,620 --> 00:17:47,600
+هذه أم المرأة الحامل عندها 50% نسبة إنها تكون
+
+182
+00:17:47,600 --> 00:17:54,760
+Career عندها نسبة 50% تعطي أولادها وبناتها الجين
+
+183
+00:17:54,760 --> 00:18:01,330
+المصاب وإذا عشان يكون مصاب لازم يكون Maleما بنفعل
+
+184
+00:18:01,330 --> 00:18:04,210
+«the female» «the female» راح تطلع career زي إذا
+
+185
+00:18:04,210 --> 00:18:09,290
+كانت أمها مصابة يعني حامل الجين يعني فنص و نص و نص
+
+186
+00:18:09,290 --> 00:18:18,290
+بطلع 81 أتأمل أنها تكون واضحة في أسئلة ثانية؟ بدكم
+
+187
+00:18:18,290 --> 00:18:25,190
+هيك رقم سؤال ناخده؟
+
+188
+00:18:25,190 --> 00:18:31,820
+في سؤال رقم جديد في «blogball»فان فكرته بيحكي عن
+
+189
+00:18:31,820 --> 00:18:43,380
+«هارفيند» أو «هارفيند» بيحكي
+
+190
+00:18:43,380 --> 00:18:44,820
+عن «هارفيند» أو «هارفيند» بيحكي عن «هارفيند» بيحكي
+
+191
+00:18:44,820 --> 00:18:45,120
+عن «هارفيند» بيحكي عن «هارفيند» بيحكي عن «هارفيند»
+
+192
+00:18:45,120 --> 00:18:46,000
+بيحكي عن «هارفيند» بيحكي عن «هارفيند» بيحكي عن
+
+193
+00:18:46,000 --> 00:18:46,060
+«هارفيند» بيحكي عن «هارفيند» بيحكي عن «هارفيند»
+
+194
+00:18:46,060 --> 00:18:53,380
+بيحكي عن «هارفيند» بيحكي عن «هارفيند»
+
+195
+00:18:53,380 --> 00:18:58,800
+بيحكي عن «هارفيند» بيحكي عن «هارفيند» بيحكي عن «
+
+196
+00:19:01,690 --> 00:19:06,090
+السؤال اللي جاب ليه اللي جاب ليه طيب خلينا نشوف
+
+197
+00:19:06,090 --> 00:19:11,390
+طيب
+
+198
+00:19:11,390 --> 00:19:22,090
+خلينا نشوف بدك كريم اقرأ السؤال خلينا نشوف واضح
+
+199
+00:19:22,090 --> 00:19:22,970
+عندك السؤال؟
+
+200
+00:19:32,830 --> 00:19:38,470
+كريم أو أي حد ثاني
+
+201
+00:19:38,470 --> 00:19:54,970
+مش
+
+202
+00:19:54,970 --> 00:20:00,290
+عارف، بحب انتم تشاركوا معاه يعني بس مش أنا أقعد
+
+203
+00:20:00,290 --> 00:20:09,360
+أتكلم إذاما اسمه؟ إذا مرات واضح، مش واضح، نشوفه A
+
+204
+00:20:09,360 --> 00:20:14,640
+31-year-old woman comes to the office as she and
+
+205
+00:20:14,640 --> 00:20:20,140
+her husband desire a second child ماشي؟ The
+
+206
+00:20:20,140 --> 00:20:26,920
+husband is infertile and the patient's son who was
+
+207
+00:20:26,920 --> 00:20:31,640
+conceived via donor inseminationكانت مؤكدًا
+
+208
+00:20:31,640 --> 00:20:37,180
+بـGlycogen Storage Disease Type 2 اللي هو
+
+209
+00:20:37,180 --> 00:20:42,420
+الـBombay Disease الأن
+
+210
+00:20:42,420 --> 00:20:49,580
+هؤلاء الـMetabolic Disorders، ما هو اسمه؟ أيش
+
+211
+00:20:49,580 --> 00:20:53,680
+الـInheritance تبعتهم؟ يعني هو أنا كويس في الأسئلة
+
+212
+00:20:53,680 --> 00:20:59,290
+هذهحتى بأعطيك تعليم، يعني شو فيه بعض المعلومات على
+
+213
+00:20:59,290 --> 00:21:02,350
+الأقل لأنه مش متوقع أنك أنت بتعرفوا أو سمعت فيها
+
+214
+00:21:02,350 --> 00:21:05,870
+The Bombay's Disease Glycogen Storage Disease
+
+215
+00:21:05,870 --> 00:21:13,330
+بيكون Hepatosplenomegaly بيكون Decreased Oxygen أو
+
+216
+00:21:13,330 --> 00:21:19,910
+يعني قوة العضلات أضعف وضعف وكده وعادة مشكلة كبيرة
+
+217
+00:21:21,520 --> 00:21:27,080
+هذه مصابة عادية لـ Autosomal Recession معروفة
+
+218
+00:21:27,080 --> 00:21:35,660
+لتأثير واحد في أربعين ألف في المجتمع العام ماشي،
+
+219
+00:21:35,660 --> 00:21:42,260
+شو بنستفيد من هذا الكلام؟ مين يجاوبني؟ كل واحد من
+
+220
+00:21:42,260 --> 00:21:46,540
+أربعين ألف مصاب،
+
+221
+00:21:46,540 --> 00:21:53,550
+أيوة كريمنعم تقدر تطلع الـ «Q» اللي هو الـ «points
+
+222
+00:21:53,550 --> 00:22:02,610
+of rest of the قليل» طبعا، تمام، كم بتطلع؟ بتجيب
+
+223
+00:22:02,610 --> 00:22:07,970
+الـ «square root» للـ 40 ألف هاد وبيطلع واحد على
+
+224
+00:22:07,970 --> 00:22:14,210
+ميتين واحد على ميتين، تمام، ماشي، فيعني هسة في
+
+225
+00:22:14,210 --> 00:22:25,890
+معلومات أخدناهاالقصة اللي بيحكوها هنا أن الزلمة
+
+226
+00:22:25,890 --> 00:22:32,310
+يعني هدول ال couple هدول الزوجين عملوا شغل بدهم
+
+227
+00:22:32,310 --> 00:22:40,870
+يخلفوا الزلمة مافيش endosperm و بيخلفش فراحت هي مع
+
+228
+00:22:40,870 --> 00:22:46,370
+زوجها راحوا على تبعين اللي بيعملوااللي هو التلقيح
+
+229
+00:22:46,370 --> 00:22:51,150
+بالأنبيب أو زراعة أنبيب للأطفال لزراعة الأطفال
+
+230
+00:22:51,150 --> 00:22:58,150
+بالأنبيب وأخذت حيوان منوي من أي واحد من الـ
+
+231
+00:22:58,150 --> 00:23:05,310
+General population السائلين وأجت الطفل اللي ولدته
+
+232
+00:23:05,310 --> 00:23:10,910
+بهذه الطريقة عنده هذه الإصابة المرض النادر هذا طلع
+
+233
+00:23:10,910 --> 00:23:17,680
+الطفل المصابماشي، فهذه قصتها Genetic
+
+234
+00:23:17,680 --> 00:23:21,660
+Testing Confirms That The Patient Is A Carrier For
+
+235
+00:23:21,660 --> 00:23:27,460
+The Disease طلعت الجين المصاب هو في ال .. كنسبة
+
+236
+00:23:27,460 --> 00:23:34,480
+الأليل في ال population واحد على ميتين فالإصابة
+
+237
+00:23:34,480 --> 00:23:40,680
+بتكون واحد في الأربعين ألف اللي هي Q تربيع ماشي
+
+238
+00:23:42,480 --> 00:23:50,600
+الآن ما ستفعل؟ هي Carrier فإنه
+
+239
+00:23:50,600 --> 00:23:57,860
+الأول طلع بهذا الشكل معناته إنه نصيبهم إن الشخص
+
+240
+00:23:57,860 --> 00:24:03,280
+الثاني اللي أخذوا منه بشكل عمياني
+
+241
+00:24:03,280 --> 00:24:11,270
+الـ Spare طلع عنده الـ Carrier للجين هذاوبالتالي
+
+242
+00:24:11,270 --> 00:24:14,330
+autosome-recessive فواحد من هذا الـ 40 ألف طلع
+
+243
+00:24:14,330 --> 00:24:18,950
+بهذا الطفل اللي عنده بالأول a different sperm
+
+244
+00:24:18,950 --> 00:24:22,770
+donor is selected with no personal or family
+
+245
+00:24:22,770 --> 00:24:27,210
+history of Bombay disease however his career
+
+246
+00:24:27,210 --> 00:24:31,550
+status is unknown فقرروا المرة الثانية بيعدوا نفس
+
+247
+00:24:31,550 --> 00:24:36,330
+الشغل بس المرة هذه قالوا خلينا ناخد حد ثاني فاخدوا
+
+248
+00:24:36,330 --> 00:24:41,790
+شخص آخربس برضه مش جادرين يكونوا متأكدين إنه ما
+
+249
+00:24:41,790 --> 00:24:45,510
+عنده المرض وفي الغالب اللي بتبرع بهذه الشغلات يكون
+
+250
+00:24:45,510 --> 00:24:49,830
+يفترض إنه هيك على الأقل مظهريًا إنه إنسان سليم
+
+251
+00:24:49,830 --> 00:24:57,990
+وطبيعي وكذا وكذلك يعني، ماشي؟ So، الآن السؤال What
+
+252
+00:24:57,990 --> 00:25:02,350
+is the probability of the patient having an
+
+253
+00:25:02,350 --> 00:25:10,500
+affected child with the new sperm donor؟الأن الأم
+
+254
+00:25:10,500 --> 00:25:19,100
+اللي هي هاي بتسأل هي أكيد إيش؟ مصابة ولا career
+
+255
+00:25:19,100 --> 00:25:24,960
+ولا طبيعي؟ ‏- career ‏- لازم تكون career، صح؟ ‏-
+
+256
+00:25:24,960 --> 00:25:29,020
+لازم تكون career ‏- لازم تكون career ‏- لازم تكون
+
+257
+00:25:29,020 --> 00:25:30,620
+career ‏- لازم تكون career ‏- لازم تكون career ‏-
+
+258
+00:25:30,620 --> 00:25:30,800
+لازم تكون career ‏- لازم تكون career ‏- لازم تكون
+
+259
+00:25:30,800 --> 00:25:30,840
+career ‏- لازم تكون career ‏- لازم تكون career ‏-
+
+260
+00:25:30,840 --> 00:25:35,160
+career ‏- لازم تكون career ‏-
+
+261
+00:25:38,190 --> 00:25:42,610
+مش لسه بدي أدرس أو كده لأنه هذا autism and
+
+262
+00:25:42,610 --> 00:25:48,830
+recessive وفيه طفل مصاب إذن الأم والأب الحقيقي
+
+263
+00:25:48,830 --> 00:25:52,730
+أثنينهم لازم يكونوا career ما بيصير يعني ما راح
+
+264
+00:25:52,730 --> 00:25:58,170
+يطلع autism and recessive ومافيش career يعني أو
+
+265
+00:25:58,170 --> 00:26:02,310
+واحد بس اللي career لازم أثنين career فالآن
+
+266
+00:26:02,310 --> 00:26:05,510
+الحكينا
+
+267
+00:26:05,510 --> 00:26:13,900
+الأمشو احتمالية إنها تعطي الجين الأليل المصاب؟ هي
+
+268
+00:26:13,900 --> 00:26:22,880
+career إذا الاحتمال إيش؟ نص وجابوا sperm جديد من
+
+269
+00:26:22,880 --> 00:26:27,500
+الـGeneral population فداش احتمالية إنه يكون حامل
+
+270
+00:26:27,500 --> 00:26:34,640
+للجين تبع المرض؟ اللي هي الـQ اللي طلعناها من الـQ
+
+271
+00:26:34,640 --> 00:26:40,550
+تربيع اللي معطينيهاهو الـ Spare Donor مش راح يكون
+
+272
+00:26:40,550 --> 00:26:44,870
+affected لإنه كان لك حينورمال في 2020 –شو احتمالية
+
+273
+00:26:44,870 --> 00:26:53,730
+إن الـ Spare Donor يطلع career أو قداش الاحتمالية
+
+274
+00:26:53,730 --> 00:26:58,030
+1 على 200 لأن هذا احتمالية –إن السنة كانت من الـQE
+
+275
+00:26:58,030 --> 00:26:59,170
+–نعم
+
+276
+00:27:10,530 --> 00:27:13,690
+الـ Spare بما أنه من الـ General Population
+
+277
+00:27:13,690 --> 00:27:21,090
+احتمالية إنه يكون القليل هو المصاب واحد على ميتين
+
+278
+00:27:21,090 --> 00:27:26,870
+فاحنا بالنسبة
+
+279
+00:27:26,870 --> 00:27:34,310
+للقصة هذه والسلافة بهذه الطريقة ماشي بتقول الـ
+
+280
+00:27:34,310 --> 00:27:39,290
+General Population إنه يطلع careerونعطينا القليل
+
+281
+00:27:39,290 --> 00:27:44,370
+المصاب 1 في الميتين والمرأة هذه أنا متأكد إنها
+
+282
+00:27:44,370 --> 00:27:50,270
+Carrier فاحتمالية أن تعطينا الـ Affected قليل هو
+
+283
+00:27:50,270 --> 00:27:57,330
+نص فنص 1 على 200 بيطلع 1 على 400 فإجابتي راح تكون
+
+284
+00:27:57,330 --> 00:28:03,610
+1 على 400 لما تشوفوا الإجابة بكتبوا 1 على 400
+
+285
+00:28:03,610 --> 00:28:05,550
+ماشي؟
+
+286
+00:28:08,700 --> 00:28:14,040
+إن شاء الله واضحة كريم
+
+287
+00:28:14,040 --> 00:28:19,340
+يبدو أنه واضح السؤال، فيه نقطة أنت بدك تسأل عنها
+
+288
+00:28:19,340 --> 00:28:25,300
+في المعادلة نفسها؟
+
+289
+00:28:25,300 --> 00:28:31,590
+لأ لأ تمام، أنا بس حاطط السؤال، السؤال واضحالسؤال
+
+290
+00:28:31,590 --> 00:28:36,270
+يعني إحنا دائماً نتذكر يعني أنا بعتبر هدولة الـ
+
+291
+00:28:36,270 --> 00:28:40,490
+«ثلاث معادلات» اللي ناتج عن «هاردي وانبرج»
+
+292
+00:28:40,490 --> 00:28:45,730
+Analysis لازم لوحدك يحفظهم وإذا بدي إيجي بدك تدور
+
+293
+00:28:45,730 --> 00:28:50,130
+عليهم زي ما سوينه هنا لما يجيني يعطيني
+
+294
+00:28:50,130 --> 00:28:59,270
+الـPrevalence أو مدى انتشار المرض اللي هو الـQ
+
+295
+00:28:59,270 --> 00:29:05,460
+تربيعالـ frequency of the disease individual
+
+296
+00:29:05,460 --> 00:29:10,400
+نسبتهم high لـ Q تربية إذاً الـ frequency تبعت
+
+297
+00:29:10,400 --> 00:29:16,640
+الأليل تخلط جدر فهذه أعطاني نسبة احتمالية أنه يكون
+
+298
+00:29:16,640 --> 00:29:21,180
+الواحد carrier لهذا الـ rare disease هنا واحد على
+
+299
+00:29:21,180 --> 00:29:29,090
+ميتين والأم في الحالة هذه أنا متأكد نص لأنهاعندها
+
+300
+00:29:29,090 --> 00:29:35,710
+هي لازم تكون career فالحال الأولى هيك نصيبة أنه
+
+301
+00:29:35,710 --> 00:29:39,970
+منها المتين ال individual اللي أخدت منه ال spare
+
+302
+00:29:39,970 --> 00:29:44,950
+كان كمان career يعني هاي لو كانت يعني زي ما نقول
+
+303
+00:29:44,950 --> 00:29:50,430
+اتجوزته فأسا عندها خيار ثاني بدأ تغير وجابت إنسان
+
+304
+00:29:50,430 --> 00:29:57,940
+ثاني يظلفي قضية الاحتمالات إنه إذا صار إشي أول مرة
+
+305
+00:29:57,940 --> 00:30:02,800
+مش بالضرورة إنه يصير المرة الثانية كل حمل إشي
+
+306
+00:30:02,800 --> 00:30:08,520
+منفصل والنسب بتظلها ثابتة دا نفس الأباء يعني فهنا
+
+307
+00:30:08,520 --> 00:30:14,760
+واحد ثاني برضه واحد على متين فهي الاحتمالية نصف
+
+308
+00:30:14,760 --> 00:30:20,020
+فبتصير واحد على أربعمية فهيك بتمشي الأمور ماشي في
+
+309
+00:30:20,020 --> 00:30:20,840
+أسئلة أخرى
+
+310
+00:30:27,340 --> 00:30:33,120
+إذا حد بالـChat عنده استفسار على سؤال آخر، نشوف
+
+311
+00:30:33,120 --> 00:30:36,280
+الـChat، آه
+
+312
+00:30:41,500 --> 00:30:45,760
+دكتور إذا الأسئلة اللي أنت حكيت إنه فيها الـ Stop
+
+313
+00:30:45,760 --> 00:30:54,220
+Codons اللي هي EATT والـ CATT هذه اللي ما .. يعني
+
+314
+00:30:54,220 --> 00:30:58,240
+ما ركزت أنت عليها في الاشياء؟ لأ أنا .. أنا الفكرة
+
+315
+00:30:58,240 --> 00:31:02,000
+يعني إذا قريت السؤال اللي جابة هايش الأسئلة على
+
+316
+00:31:02,000 --> 00:31:07,900
+هذه النقطة يعني هي الـ trick اللي فيها إنك أنت
+
+317
+00:31:07,900 --> 00:31:14,560
+تنتبه إذاالـ Codon لـ Amino Acid في النُص، في نُص
+
+318
+00:31:14,560 --> 00:31:21,360
+البروتين، اتحول لـ Stop Codon، شو رح يصير؟ هلية
+
+319
+00:31:21,360 --> 00:31:26,140
+بناء البروتين رح توقف، فراح يبقى لك البروتين
+
+320
+00:31:26,140 --> 00:31:30,460
+الناتج، هو بيقولك البروتين الناتج قصير، البروتين
+
+321
+00:31:30,460 --> 00:31:37,380
+الناتج مش مظبوط، والسبب أن هاي اتغيرت لهاي، فاهم
+
+322
+00:31:37,380 --> 00:31:42,640
+عليك كيف؟ففي الحالة هذه لما نشوف إنه كتاب لك يعني
+
+323
+00:31:42,640 --> 00:31:48,880
+هظهرني هذا السؤال الثاني أو الثالث خلّينا يعني
+
+324
+00:31:48,880 --> 00:31:56,900
+أشوف يعني أنا استغربت يعني هم الكتب بتتكلم على
+
+325
+00:31:56,900 --> 00:32:01,600
+أشياء مختلفة يعني فيه مرات
+
+326
+00:32:04,070 --> 00:32:09,350
+يعني الـ Diseases ولا كده اللي بيشرحوا عنه هي
+
+327
+00:32:09,350 --> 00:32:15,530
+بتعطيك فكرة ولا هذي
+
+328
+00:32:15,530 --> 00:32:23,410
+بس لـGen دقيقة خلّيني أطلّق السؤال، إيش اسمه؟ اللي
+
+329
+00:32:23,410 --> 00:32:28,370
+هو إنه عن الـAlternative Splicing
+
+330
+00:32:35,100 --> 00:32:41,880
+أنا هسا بدنا نروح ندور على السؤال بس لما نكون أنه
+
+331
+00:32:41,880 --> 00:32:46,180
+يعني بهو بصفلك يعني الـ… الـ… الـ… الكويس في
+
+332
+00:32:46,180 --> 00:32:51,060
+الأسئلة هذولة صراحة كقالية الدراسة أن نفسي استم
+
+333
+00:32:51,060 --> 00:32:56,360
+السؤال هو هتطلق معلومات يعني أنا هسا مثلا شرحنا
+
+334
+00:32:56,360 --> 00:33:02,150
+موضوع الـHemophilia بشكلأكتر شوية أنا مش قصدي هذا
+
+335
+00:33:02,150 --> 00:33:05,690
+أن نكون hematology lecture يعني إحنا هذه المفروض
+
+336
+00:33:05,690 --> 00:33:08,670
+تاخدوها بالـ hematology إحنا بدأنا نركز على الـ
+
+337
+00:33:08,670 --> 00:33:14,670
+genetics فالـ genetics يعني simple وهي هذه ال
+
+338
+00:33:14,670 --> 00:33:21,490
+rules تبعتها بحيث أنه لما نشوف الكلام اللي كاتبينه
+
+339
+00:33:21,490 --> 00:33:27,750
+بهذه الطريقة شو اسمه؟ طيب
+
+340
+00:33:28,700 --> 00:33:38,680
+هذا أظن السؤال الثامن، ولا لأ؟ يعني
+
+341
+00:33:38,680 --> 00:33:43,200
+الأسئلة، استم الأسئلة صراحة دكتور أحمد، فيها
+
+342
+00:33:43,200 --> 00:33:49,660
+معلومات مفيدة، يعني أنت تخيلتها وكذا، بتلاقيك، و
+
+343
+00:33:49,660 --> 00:33:51,920
+بتستخدم، شو اسمه؟
+
+344
+00:33:56,640 --> 00:33:59,860
+المحققين يقومون بإزالة عيوب البشر ويقومون بإزالة
+
+345
+00:33:59,860 --> 00:34:01,120
+مصدر RNA محدث محدث محدث محدث محدث محدث محدث محدث
+
+346
+00:34:01,120 --> 00:34:02,480
+محدث محدث محدث محدث محدث محدث محدث محدث محدث محدث
+
+347
+00:34:02,480 --> 00:34:03,120
+محدث محدث محدث محدث محدث محدث محدث محدث محدث محدث
+
+348
+00:34:03,120 --> 00:34:07,020
+محدث محدث محدث محدث محدث محدث محدث محدث محدث محدث
+
+349
+00:34:07,020 --> 00:34:07,160
+محدث محدث محدث محدث محدث محدث محدث محدث محدث محدث
+
+350
+00:34:07,160 --> 00:34:08,340
+محدث محدث محدث محدث محدث محدث محدث محدث محدث محدث
+
+351
+00:34:08,340 --> 00:34:23,020
+محدث محدث محدث محدث محدث
+
+352
+00:34:23,020 --> 00:34:29,530
+مبعد إدخال الـ Vector إلى مجموعات بكتيريا
+
+353
+00:34:29,530 --> 00:34:34,130
+المناسبة، يتغير البكتيريا الهياركولترية إلى مجموعة
+
+354
+00:34:34,130 --> 00:34:39,470
+بيو-رياكترية لإنشاء كميات كبيرة من البروتين اللي
+
+355
+00:34:39,470 --> 00:34:43,390
+تحتوي على المنطقة التي تتعامل مع مجموعة DNA محددة،
+
+356
+00:34:43,390 --> 00:34:48,070
+هذه البروتين هي أكتر مستحيلًا مستخدمة لأي نوع من
+
+357
+00:34:48,070 --> 00:34:50,110
+الهرمونات التالية،
+
+358
+00:34:55,350 --> 00:35:03,230
+بروجسترون؟ والله ما أفهم هذا يعني العيب
+
+359
+00:35:03,230 --> 00:35:10,630
+في السؤال هذا بالنقطة الأولى أنه
+
+360
+00:35:10,630 --> 00:35:16,830
+إذا ما عندك معلومات ثانية الكلام اللي حطه بخربطك
+
+361
+00:35:16,830 --> 00:35:22,880
+ومش مفيد كثير كثير بالنسبة بعض الأحيان يعنيهذه
+
+362
+00:35:22,880 --> 00:35:30,260
+تحتاج إلى معلومة تكون عارفها الآن بسأل، بسأل مثل
+
+363
+00:35:30,260 --> 00:35:37,520
+كريم أو اللي بدك يعني الإنسولين اللي نستخدمه، شو
+
+364
+00:35:37,520 --> 00:35:42,060
+هو؟ من وين بتجيبه؟ شايف الإنسولين الإبرة اللي
+
+365
+00:35:42,060 --> 00:35:45,880
+بنعطي المرضى السكري؟ سواء type 1 أو type 2،
+
+366
+00:35:45,880 --> 00:35:49,260
+بنعطيهم إنسولين، من وين بنجيبه؟
+
+367
+00:35:56,590 --> 00:36:02,290
+أي طالب بيحب يشارك؟
+
+368
+00:36:02,290 --> 00:36:09,690
+نعم أهلا
+
+369
+00:36:09,690 --> 00:36:14,210
+وسهلا الله يرضى عليك يا كريم أنت أو أي طالب ثاني
+
+370
+00:36:14,210 --> 00:36:19,550
+الإنسولين اللي بنستخدمه في علاج الآن مرضى السكري
+
+371
+00:36:19,550 --> 00:36:23,930
+بنقول عنه human insulin من وين بنجيبه؟
+
+372
+00:36:27,400 --> 00:36:33,840
+وصلّه في المختبرات آه، كيف؟
+
+373
+00:36:33,840 --> 00:36:37,480
+أعتقد أول ما استخلصوه، استخلصوه من القرن وبعدين
+
+374
+00:36:37,480 --> 00:36:43,180
+صاروا ياخدوا الجينات من الإنسان وصاروا البروتينات
+
+375
+00:36:43,180 --> 00:36:48,860
+في المختبر صحيح، لأ، مش بالمختبر، مختبر، يعني هيك
+
+376
+00:36:48,860 --> 00:36:52,240
+فالنسبة
+
+377
+00:36:52,240 --> 00:36:53,420
+لهذا الموضوع
+
+378
+00:36:56,560 --> 00:37:04,260
+بالنسبة للـ «إنسولين»
+
+379
+00:37:04,260 --> 00:37:10,660
+زمان أول شيء كانوا يعزلوا الهرمون اللي هو البروتين
+
+380
+00:37:10,660 --> 00:37:18,640
+يعزلوا من البقر ومن البقرة الكبيرة فيقدروا يفلتروا
+
+381
+00:37:18,640 --> 00:37:22,640
+دمها ويعزلوا شوية البروتين اللي هو الـ «إنسولين»
+
+382
+00:37:22,640 --> 00:37:28,270
+تبع البقروبعدين يحقق الإنسان فيه فهيك يعني أصلا
+
+383
+00:37:28,270 --> 00:37:35,610
+هذا البروتين مش متطابق كتير مع المستقبل للإنسولين
+
+384
+00:37:35,610 --> 00:37:41,150
+اللي عند الإنسان ففيه مشكلة زائد أنه يعني تركيبته
+
+385
+00:37:41,150 --> 00:37:45,970
+شويه مختلفة عن الإنسولين البشري وبالتالي فيه مشكلة
+
+386
+00:37:45,970 --> 00:37:50,650
+فبالتالي ماكنش نافع كتير بس المرضى كان يموتوا
+
+387
+00:37:50,650 --> 00:37:56,520
+ومضطرين نعطيهم يام تمام؟فهسا لما تقول أنت يا كريم
+
+388
+00:37:56,520 --> 00:38:02,480
+كيف صنعوه في المختبر الـ stem السؤال بيشرح كيف
+
+389
+00:38:02,480 --> 00:38:07,360
+صنعوه الأصل
+
+390
+00:38:07,360 --> 00:38:13,080
+لما أنت أنت بتكون مهتم بهذا الشيء هدفك أول شيء
+
+391
+00:38:13,080 --> 00:38:19,460
+تأذل الـ gene تبعه ماشي بدك تأذل الـ DNA اللي
+
+392
+00:38:19,460 --> 00:38:26,330
+بيحتوي الـ Insulin تبعهالـ الـ الاشي اللي أنت بدك
+
+393
+00:38:26,330 --> 00:38:32,170
+إيه فيه مشكلة بالنسبة للمن تقول أنا بدي أخد الـ
+
+394
+00:38:32,170 --> 00:38:36,790
+«جين» أو الـ «DNA» مباشرة من الإنسان أنه فيه إشي
+
+395
+00:38:36,790 --> 00:38:40,470
+اسمه «Intron وإكسون» يعني لما تاخد أنت الـ «DNA»
+
+396
+00:38:40,470 --> 00:38:46,470
+كله ما بتقدر تاخد يعني القطعة اللي لازم بس هي اللي
+
+397
+00:38:46,470 --> 00:38:49,950
+تصيرها الـ Transcription و Translation بحيث تصير
+
+398
+00:38:49,950 --> 00:38:56,200
+Amino Acidبدك تأخذ كل الـ DNA فالأسهل مرات إنك إذا
+
+399
+00:38:56,200 --> 00:39:01,900
+بتدور على الإشي الـ Messenger RNA تبعه ماشي فإذا
+
+400
+00:39:01,900 --> 00:39:08,320
+أنت مهتم بإشي بروح بجيب خلية و بدور على بعزل الـ
+
+401
+00:39:08,320 --> 00:39:13,060
+Messenger RNA تبع الإشي لإنه يكون الخلية جاهزة
+
+402
+00:39:13,060 --> 00:39:17,210
+بالشكل اللي أنا بديهااللي هو اللي حقيقةً كامل
+
+403
+00:39:17,210 --> 00:39:22,310
+وبيدياه كـ Amino Acid واشي تحطيهن الـ Protein
+
+404
+00:39:22,310 --> 00:39:29,330
+مابدي الـ Exons و الـ Introns الجزء الإضافي فهو
+
+405
+00:39:29,330 --> 00:39:36,150
+أنا بقولك أنا روحت وعزلت الـ RNA الـ RNA بالألات
+
+406
+00:39:36,150 --> 00:39:41,370
+في المختبر بقدر بالـ PCRبالـ Polymerase Chain
+
+407
+00:39:41,370 --> 00:39:48,270
+Reaction أول شي جبت، شو اسمه؟ جبت الـ RNA بـ
+
+408
+00:39:48,270 --> 00:39:51,770
+Reverse Transcriptase اللي هو الـ Enzyme اللي
+
+409
+00:39:51,770 --> 00:39:58,690
+وظيفته طلّق للـ DNA للـ RNA هذا كونت RNA DNA
+
+410
+00:39:58,690 --> 00:40:04,030
+Double Strand حطيت قدامها Promoter وحطيت
+
+411
+00:40:04,030 --> 00:40:10,230
+Terminator بالأخير وهذولا حطيتهم بـ P-VectorVector
+
+412
+00:40:10,230 --> 00:40:19,730
+يعني فيروس بيحكم حاله في البكتيريا كل الشغل هذا
+
+413
+00:40:19,730 --> 00:40:24,770
+لأنه الشغل على الـ Cell Culture صعب بكتيريا الـ
+
+414
+00:40:24,770 --> 00:40:29,950
+Culture في المختبر أسهل بكتير فأنا لما كيف أصلا
+
+415
+00:40:29,950 --> 00:40:33,810
+بنصنع الإنسولين وهذا بداية سؤالي أنه في الغالب
+
+416
+00:40:34,610 --> 00:40:38,610
+جابوا الـ RNA تبع الإنسلين ورجعوا له الـ DNA
+
+417
+00:40:38,610 --> 00:40:42,490
+الكامل اللي بدنا إياه مش زي ما في جسم الإنسان
+
+418
+00:40:42,490 --> 00:40:48,650
+أحيانًا فيه Introns وExons و بعدين حولناها لـ DNA
+
+419
+00:40:48,650 --> 00:40:54,690
+و الـ DNA حطيت إشي يجبر البكتيريا تعرف وين تبدأ و
+
+420
+00:40:54,690 --> 00:40:59,140
+وين توقف الـ Promoter عشان تبدأوالـ Terminator
+
+421
+00:40:59,140 --> 00:41:04,640
+عشان يتوقف عشان أكون سخلي أو أشتغلي على القطعة هذه
+
+422
+00:41:04,640 --> 00:41:09,320
+بحطها في الـ Vector اللي هو الـ Virus الـ Plasmid
+
+423
+00:41:09,320 --> 00:41:14,940
+عشان ينحقن جوا بكتيريا وجوا البكتيريا بتطير هذه
+
+424
+00:41:14,940 --> 00:41:24,710
+الشغلتتم، شو بيسموها، يعني بتتم الـ Translation،
+
+425
+00:41:24,710 --> 00:41:27,590
+الـ Transcription و Translation فبتعطيني الـ
+
+426
+00:41:27,590 --> 00:41:33,210
+Protein اللي بدّيها فهذا كله الجزء الأول بيشرح هذه
+
+427
+00:41:33,210 --> 00:41:38,830
+القاعدة أو بيشرح هذه النقطة بالنسبة
+
+428
+00:41:38,830 --> 00:41:41,910
+للسؤال
+
+429
+00:41:41,910 --> 00:41:43,850
+هنا يعني
+
+430
+00:41:45,510 --> 00:41:50,330
+هذه اللي عملوها عشان ينتجوا هذا الأمر لأنه هرمون
+
+431
+00:41:50,330 --> 00:41:53,450
+والله ما بعرف يعني أنا اللي بعرفه اللي هو
+
+432
+00:41:53,450 --> 00:41:58,830
+الإنسولين بدرجة أساسية بس بيعملوه لبروتين تبع
+
+433
+00:41:58,830 --> 00:42:01,190
+الإنسولين اللي احنا بدناه عشان هيك بيسموها
+
+434
+00:42:01,190 --> 00:42:04,790
+«Recomponent DNA Technology» «Recomponent» يعني
+
+435
+00:42:04,790 --> 00:42:08,730
+أنت بتحط تبع الفيروس على تبع البكتيريا على تبع
+
+436
+00:42:08,730 --> 00:42:16,090
+الإنسان على تبع كذا، بتحط DNA مختلفةبس بيظل هي نفس
+
+437
+00:42:16,090 --> 00:42:20,590
+المبادئ DNA لـ RNA لـ Polypeptide chain يعني بدك
+
+438
+00:42:20,590 --> 00:42:26,370
+تكون تمشي بالثلاث مقارنة فهي الآن البروجيسترون هو
+
+439
+00:42:26,370 --> 00:42:33,810
+اللي بيحطوله شكله يمكن باللي بيكونوا عندهم مثلا
+
+440
+00:42:33,810 --> 00:42:40,310
+الـ cancer أو الـ issue البروجيسترون أو الـ other
+
+441
+00:42:40,310 --> 00:42:50,580
+thingsكـ Blocker أو إشي فالـ
+
+442
+00:42:50,580 --> 00:42:53,660
+الشغل
+
+443
+00:42:53,660 --> 00:43:00,820
+اللي بدك تتكلم عنها ماشي اللي
+
+444
+00:43:00,820 --> 00:43:06,800
+هو موضوع إنه الـ الـ الـ protein hormones الـ
+
+445
+00:43:06,800 --> 00:43:10,780
+receptor اللي لهم على سطح الخلية الـ lipid hormone
+
+446
+00:43:11,270 --> 00:43:15,990
+اللي هم الـ Steroids، فيه Glucocorticoids،
+
+447
+00:43:15,990 --> 00:43:19,530
+Mineralocorticoids، Sex Hormones، الأشياء اللي زي
+
+448
+00:43:19,530 --> 00:43:24,590
+هيكي الـ Receptor تبعهم Intracytoplasmic فهنا يعني
+
+449
+00:43:24,590 --> 00:43:28,690
+أنا أظن السؤال، الـ trick اللي فيهإن هدولة كلهم
+
+450
+00:43:28,690 --> 00:43:32,810
+بالأخير بروتينات الـ glucagon والإنسلين
+
+451
+00:43:32,810 --> 00:43:38,170
+والإنسلينات والبروتيرويد والبروجسترول والوحيد الـ
+
+452
+00:43:38,170 --> 00:43:42,130
+intraceptive platelet مني فاهم أنا يعني أكيد
+
+453
+00:43:42,130 --> 00:43:50,060
+جابتهم صحيحة ماشيبس هنا بقولك DNA-binding proteins
+
+454
+00:43:50,060 --> 00:43:53,880
+include transcription factors، Steroids receptors
+
+455
+00:43:53,880 --> 00:43:56,820
+and thyroid hormone receptors, fat-soluble
+
+456
+00:43:56,820 --> 00:44:00,360
+receptors, vitamin D، DNA transcription or
+
+457
+00:44:00,360 --> 00:44:10,960
+replication proteins، ماشي، سؤال صعب ويعني بتكلم
+
+458
+00:44:10,960 --> 00:44:14,340
+عن مواضيع عميقة كتير ويعني
+
+459
+00:44:15,680 --> 00:44:20,920
+بدو الواحد على الأقل يعني أنا لو طلعت على السؤال
+
+460
+00:44:20,920 --> 00:44:25,540
+ما كنت راح عارف أتجاوبه كنت راح أقول يمكن الـhigh
+
+461
+00:44:25,540 --> 00:44:30,520
+البروجيسترون على أساس هو من نوعية مختلفة يعني استم
+
+462
+00:44:30,520 --> 00:44:34,440
+السؤال الواضح في أشياء كتير وبعدين بيجي بالأخير
+
+463
+00:44:34,440 --> 00:44:38,720
+يقولك أن هذا receptor لهرمون أنوه هرمون هذا والله
+
+464
+00:44:38,720 --> 00:44:40,860
+ما بعرفها ماكنت عارفها من قبل
+
+465
+00:44:45,120 --> 00:44:54,080
+في سؤال من دكتورة نادية في السؤال السابق اللي كان
+
+466
+00:44:54,080 --> 00:44:59,840
+فيه عن الـ Weinberg equation يقول دكتور المفترض
+
+467
+00:44:59,840 --> 00:45:05,260
+احتمالية أنه يكون حامل للمرض هي 2Q ومش Q واحتمال
+
+468
+00:45:05,260 --> 00:45:10,510
+أنه ينقل الأليل المصاب في حالة لو كان حامل هي نصمش
+
+469
+00:45:10,510 --> 00:45:17,210
+عارف هي بتسأل ولا بتعلق؟ مش موجودة اللي بدونها
+
+470
+00:45:17,210 --> 00:45:23,410
+طلعت أو شي زي هي ناشي دكتور أحمد بدك تبلغك التالي
+
+471
+00:45:23,410 --> 00:45:30,490
+في فرق بين نظري ناشي و بين إنسان أنا عندي معلومة
+
+472
+00:45:30,490 --> 00:45:42,890
+عنه أسا أنا عندي شخصين حاملين careerماشي يعني ال
+
+473
+00:45:42,890 --> 00:45:47,830
+.. لما ال .. السؤال اللي بتحكي عنه عن المعادلة
+
+474
+00:45:47,830 --> 00:45:52,170
+دكتور أحمد معايا الله يطبع عليه صحيح يا دكتور
+
+475
+00:45:52,170 --> 00:45:59,450
+اتنين عندهم طفل مصاب إذن الأب والأم شوا لـ X
+
+476
+00:45:59,450 --> 00:46:02,350
+-linked recesses أو Autosomal recesses خليني أقول
+
+477
+00:46:02,350 --> 00:46:04,110
+Autosomal recesses ماشي
+
+478
+00:46:08,330 --> 00:46:16,830
+لما نكون على حسب المعادلة إثنين عندهم career صح؟
+
+479
+00:46:16,830 --> 00:46:20,650
+تمام؟
+
+480
+00:46:20,650 --> 00:46:26,090
+تمام إن شاء الله إذا في طفل مصاب معناته أكيد الأب
+
+481
+00:46:26,090 --> 00:46:34,310
+و الأم career صح؟ صحيح أفرضجابوا بدهم يجيبوا بدهم
+
+482
+00:46:34,310 --> 00:46:43,110
+يخلفوا عندهم طفل شو اسمه؟ عندهم طفل يعني حامل
+
+483
+00:46:43,110 --> 00:46:50,370
+مرافيه وبدنا نسأل شو نسبت إنه يطلع career إنه يطلع
+
+484
+00:46:50,370 --> 00:46:57,870
+career ماشي نص إنه يطلع إنسان مصاب ربع إنه يطلع
+
+485
+00:46:57,870 --> 00:47:03,070
+completely healthy ربعهذولا النسب لشخص أنا ما بعرف
+
+486
+00:47:03,070 --> 00:47:08,490
+هو راح يطلع مصاب ولا مش مصاب فاهم عليك أيه؟ بس زي
+
+487
+00:47:08,490 --> 00:47:13,510
+النسب اللي أخدناها البنت
+
+488
+00:47:13,510 --> 00:47:22,630
+هذه ماشي اللي كانت تسأل لأنه هي حامل وأخوها مصاب
+
+489
+00:47:22,630 --> 00:47:31,890
+ماشي هي في احتمال أنها تكون مصابة؟ شو رأيك؟إذا كان
+
+490
+00:47:31,890 --> 00:47:35,450
+الوالد و الوالدة، واحد منهم هو اللي بيحمل
+
+491
+00:47:35,450 --> 00:47:59,090
+الـ………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………
+
+492
+00:48:00,500 --> 00:48:07,100
+البنت لمّا أنقجت وعمرها مثلًا عشرين سنة وصارت حامل
+
+493
+00:48:08,090 --> 00:48:16,010
+ما هي احتمالية أنها تكون رُبع برُبع بنُص، رُبع
+
+494
+00:48:16,010 --> 00:48:24,470
+إنها مُصابة، رُبع إنها مُصابة،
+
+495
+00:48:24,470 --> 00:48:27,850
+رُبع إنها مُصابة، رُبع إنها مُصابة، رُبع إنها
+
+496
+00:48:27,850 --> 00:48:37,830
+مُصابة، رُبع إنها مُصابة،
+
+497
+00:48:39,660 --> 00:48:46,440
+قلنا نص؟ لأ، سلسان بيصير كده؟ بيصير سلسان صحيح،
+
+498
+00:48:46,440 --> 00:48:49,640
+لأن أنت تلغي احتمال من الـ «حامل» لغاية الربع إنه
+
+499
+00:48:49,640 --> 00:48:53,980
+حامل اللي هو المصاب، هي أكيد مش مصابة، بس شو
+
+500
+00:48:53,980 --> 00:49:00,380
+احتمالية إنها حامل، بتكون يا إما سلسة، الثلاثة
+
+501
+00:49:00,380 --> 00:49:06,160
+أرباع اللي ضايلات، بخليهم واحد، سلسة بتكون إنها
+
+502
+00:49:06,160 --> 00:49:10,580
+completely normalوثلثين إحتمالية إنها تكون
+
+503
+00:49:10,580 --> 00:49:16,140
+«Carrier» «Carrier» مظبوط وهي أنا غيرت النسب لأنه
+
+504
+00:49:16,140 --> 00:49:20,460
+أنا عرفت إنها مش مصابة هو في سؤال مشابه للفكرة هذه
+
+505
+00:49:20,460 --> 00:49:22,780
+برضه موجود في التقرير اللي فات ما احنا اتناقشنا
+
+506
+00:49:22,780 --> 00:49:29,300
+على إشي زي هيك المحاضرة اللي فاتت في سؤال نفس
+
+507
+00:49:29,300 --> 00:49:33,900
+الفكرة أو نفس المنطق موجود في الكتاب نفسه كتاب
+
+508
+00:49:33,900 --> 00:49:40,290
+كابلان أه أه أهالنسبة كانت الجواب ثلثين صحيح لأن
+
+509
+00:49:40,290 --> 00:49:43,630
+في سؤال اللي كانت الثلث أجاني واحد سألني ليش أجت
+
+510
+00:49:43,630 --> 00:49:50,510
+الثلث الثلث لأنه أنا أتأكدت إنه هي هي مش مصابة
+
+511
+00:49:50,510 --> 00:49:55,090
+مظهريًا بما أنه مش مصابة إحتمالية الجزء اللي فيه
+
+512
+00:49:55,090 --> 00:50:00,680
+بتمثل إنها مصابة لو كان لسة الأم حاملماشي، و
+
+513
+00:50:00,680 --> 00:50:07,580
+بتسألني أنت شو احتمالية أنه البنت أو اللي راح يولد
+
+514
+00:50:07,580 --> 00:50:13,780
+ولد ولا بنت يطلع مثلا career بقولك نص، مصاحب ربع،
+
+515
+00:50:13,780 --> 00:50:18,500
+أنه يكون طبيعي completely normal ربع، ماشي، إذا
+
+516
+00:50:18,500 --> 00:50:22,940
+سألني شو احتمالية مظهريا يكون طبيعي بقولك ثلاثة
+
+517
+00:50:22,940 --> 00:50:30,590
+ارباع career و normalفإذا طلعت هي Normal-looking،
+
+518
+00:50:30,590 --> 00:50:33,550
+Phenotypical هي شو احتمالية إنها تكون Career
+
+519
+00:50:33,550 --> 00:50:39,790
+الثلثانة، هيك راح تكون فهي النقطة إنه يعني الواحد
+
+520
+00:50:39,790 --> 00:50:50,770
+يرسم الجداوي ومعين يعرف هل أنا بحكي يعني لما أنصح
+
+521
+00:50:50,770 --> 00:50:56,050
+أو أجاب السؤال عن إشي أنا متأكد منهيعني اللي هي
+
+522
+00:50:56,050 --> 00:51:01,690
+إنه، يعني بالذات الأباء والأمهات اللي راح يعطوا
+
+523
+00:51:01,690 --> 00:51:07,770
+مثلا، مثلا بقولك الطفل
+
+524
+00:51:07,770 --> 00:51:12,250
+اللي هو هذا طلع عنده إصابة شو الحمل اللي بعده
+
+525
+00:51:12,250 --> 00:51:16,090
+احتمالية إنه يطلع عنده إصابة؟ الـ Autism-recessive
+
+526
+00:51:16,090 --> 00:51:20,770
+بتكون ربع لأن أنا متأكد الأباء الأثنين Carriers
+
+527
+00:51:20,770 --> 00:51:27,200
+لأنه طلع ولد مصاب من قبلفإذا من قبل أنا متأكد
+
+528
+00:51:27,200 --> 00:51:31,080
+الأثنين career يعني زي مثل الـ Bomb Disease هذا
+
+529
+00:51:31,080 --> 00:51:37,680
+الحالة الطفل الأولاني اللي جابته المرأة هذه الأبو
+
+530
+00:51:37,680 --> 00:51:42,320
+أكيد career فهو واحد منها المتين اللي عندهم
+
+531
+00:51:42,320 --> 00:51:48,920
+الـGene هذا طلع بالصدفة، بالحظ السيء إنه كمان هو
+
+532
+00:51:48,920 --> 00:51:53,970
+حامل شايف علي؟ واحد منها المتينيعني احتمالية
+
+533
+00:51:53,970 --> 00:52:00,930
+قليلة، بس هذا نصيبهم، ماشي فالآن اللي لما يقول لك
+
+534
+00:52:00,930 --> 00:52:05,130
+«طب شو احتمالية ان الطفل اللي بعده يكون نفس
+
+535
+00:52:05,130 --> 00:52:11,030
+الاشي؟» بتقول «لأن الأم بدل ما هي النسبة واحد في
+
+536
+00:52:11,030 --> 00:52:14,970
+كل أربعين ألف في الشكل الطبيعي، بما أن أنا عرفت أن
+
+537
+00:52:14,970 --> 00:52:18,790
+الأم هي الـCarrier وكانت هي اللي حامل الـGene،
+
+538
+00:52:18,790 --> 00:52:23,750
+فإذا احتمالية أن هي تنقل نصمن هناك 1 على 200 بتصير
+
+539
+00:52:23,750 --> 00:52:30,330
+1 على 400، هيك بدأ أفكر، نعم كريم كان عندك تعليق
+
+540
+00:52:30,330 --> 00:52:34,870
+حابب تحكي كنت؟
+
+541
+00:52:34,870 --> 00:52:39,450
+لقيت بخصوص سؤال 20 اللي بيحكي عن دكتوره قبل شوية،
+
+542
+00:52:39,450 --> 00:52:43,810
+هو قرأت أنا تفسير السؤال منذ فترة، فالجواب الصح هو
+
+543
+00:52:43,810 --> 00:52:48,630
+بيطلع 1400، ولكن الرقم 1 على 200 هذا ما بيجي
+
+544
+00:52:48,630 --> 00:52:54,590
+مباشر، الـNoبنفرض إن
+
+545
+00:52:54,590 --> 00:53:00,430
+الـ«سبيرم دونار» تاني يكون «كارير» وبعد هيك بفرض
+
+546
+00:53:00,430 --> 00:53:05,270
+إن احتمال توريث القليل المصاب للإبن هو نص، فلذلك
+
+547
+00:53:05,270 --> 00:53:09,570
+بنقول، بنفرض انه كارير، فبتخدم قانون اتنان و بيه،
+
+548
+00:53:09,570 --> 00:53:15,870
+يعني بنقول اتنان اي واحد على ميتين ضرب مية و تسعة
+
+549
+00:53:15,870 --> 00:53:22,500
+كريم كريمسؤالك بالشكل هذا بخطر على بالي أو كنت
+
+550
+00:53:22,500 --> 00:53:31,300
+فاكر فيه بس خلّي الأمور سهلة ماشي ال wording لما
+
+551
+00:53:31,300 --> 00:53:39,920
+نحكي على النسب ماشي الواحد على الميتين من النسخة
+
+552
+00:53:39,920 --> 00:53:45,060
+كام يعني بدك تاخدها بهذا الشكليعني صح، يعني لا،
+
+553
+00:53:45,060 --> 00:53:49,020
+لا، لا تدخل الموضوعين شويه تربطهم أتبعاد، تتفكر
+
+554
+00:53:49,020 --> 00:53:58,600
+كتير، ماشي؟ ال .. ال .. لما نقول يعني هي طريقة
+
+555
+00:53:58,600 --> 00:54:04,620
+حسبتها وطريقة التعامل معاها، ماشي؟ ال .. يعني إذا
+
+556
+00:54:04,620 --> 00:54:09,060
+حطوا واحد على 800، بد الواحد هيك يكون متفكر كتير،
+
+557
+00:54:09,060 --> 00:54:15,200
+كتير، كتير وخربط حاله، ماشي؟لما احنا نحكي الآن على
+
+558
+00:54:15,200 --> 00:54:23,060
+ال… لما مثلا تقول ال…
+
+559
+00:54:23,060 --> 00:54:32,160
+مثلا تقول مثلا اللي عندهم O blood group نقول تسعة
+
+560
+00:54:32,160 --> 00:54:39,700
+بالنسبة ليه؟ ماشي؟ ماشي الحال يا كريم؟أه دكتور
+
+561
+00:54:39,700 --> 00:54:47,340
+صحيح هاي الـQ تربية، صح؟ لأن هذا Recessive صحيح،
+
+562
+00:54:47,340 --> 00:54:58,240
+إذا شو إحتمالية إنه الـGen يكون موجود؟ شو الـQ؟
+
+563
+00:54:58,240 --> 00:55:03,260
+الـ900 نعم،
+
+564
+00:55:03,260 --> 00:55:08,860
+فهيكون الـGen 39%رح يكون ثلاث من عشرة، يعني رح
+
+565
+00:55:08,860 --> 00:55:14,780
+يكون point three، صح؟ صحيح، هاي الـ point three
+
+566
+00:55:14,780 --> 00:55:21,320
+على نسخة هون أو نسخة هناك أو النسختين مع بعض، فاهم
+
+567
+00:55:21,320 --> 00:55:27,320
+عليك كيف؟ يعني ثلاثين بالمية من الإجمالي الـ two
+
+568
+00:55:27,320 --> 00:55:32,780
+copies الممكنات في كل واحد، هي نسبتها واحد على
+
+569
+00:55:32,780 --> 00:55:38,860
+ثلاثة، هيك بدك توقفهاما بأخد إنه هذه نسبة لـ copy
+
+570
+00:55:38,860 --> 00:55:43,900
+واحدة ولا two copies ولا كده، هو هنا بيقولك إن الـ
+
+571
+00:55:43,900 --> 00:55:49,400
+Q هي نسبة إنك أنت بتيجي بتاخدالجينات تبعت هذا
+
+572
+00:55:49,400 --> 00:55:56,360
+المكان لكل الـ «population» وبتشوف قداش نسبة هذا
+
+573
+00:55:56,360 --> 00:56:00,060
+الـ «gene» طبعاً على الـ «two copies» بدي تكون
+
+574
+00:56:00,060 --> 00:56:05,800
+وإنت ما فرقت إنه one copy هاي ولا هاي ولا اثنتين
+
+575
+00:56:05,800 --> 00:56:09,940
+مع بعض فاهم عليك إيه؟ إنه إذا إنت مثلا عندك هنا
+
+576
+00:56:09,940 --> 00:56:13,160
+two copies ممكن تقول هاي ال copy الأولى وهاي ال
+
+577
+00:56:13,160 --> 00:56:18,950
+copy الثاني للـ «gene» الموقع هذافأنا هنا ما بشتغل
+
+578
+00:56:18,950 --> 00:56:23,230
+على ذاك المبدأ يعني فانت خدها ببساطة إنه لما
+
+579
+00:56:23,230 --> 00:56:28,170
+نحطولك السؤال هيك إنه أنا ما بعرف هي الـCopy
+
+580
+00:56:28,170 --> 00:56:31,670
+الأولى ولا الثاني ولا الـHomozygous إنه الثنتين
+
+581
+00:56:31,670 --> 00:56:36,250
+هيك، بس نسبة الـGene هذا هيك ببساطة في ال
+
+582
+00:56:36,250 --> 00:56:41,430
+population واحد في المتان، وهذه المرة يعني للأبو
+
+583
+00:56:41,900 --> 00:56:48,660
+للجهة هذه، نسبة توريث الأليل المصاب هو 1 على 200،
+
+584
+00:56:48,660 --> 00:56:55,300
+هيك القطة ماشي، والأم career أكيد فبالتالي، نسبة
+
+585
+00:56:55,300 --> 00:56:59,660
+أعطاها للـ Chrome للأليل هذا، 1 على 2 فبتطلع
+
+586
+00:56:59,660 --> 00:57:05,220
+النتيجة 1 على 400 ما أنا بقولت إنه أنا بتكلم على
+
+587
+00:57:05,220 --> 00:57:10,040
+نموذج إنه واحد من الـ Two copies هو الـ 1 على 200
+
+588
+00:57:10,740 --> 00:57:14,940
+لأ، ما حكيت هيك، حكيت كلها فاهم عليك كيف؟ فهذه
+
+589
+00:57:14,940 --> 00:57:19,200
+الواحد ينتبع عليها، بتخربط شوية، أه، في أسئلة
+
+590
+00:57:19,200 --> 00:57:24,080
+أخرى؟ دكتور، أظن السؤال اللي بتدور عليه هو السؤال
+
+591
+00:57:24,080 --> 00:57:30,020
+11 أه، شو السؤال 11؟ هو الأجزة الأول ولا الثاني؟
+
+592
+00:57:30,020 --> 00:57:33,960
+الأول، الأول طيب،
+
+593
+00:57:33,960 --> 00:57:41,310
+طيب، أيوة، هذا هو، ماشي؟إذا حاولنا نقرأ الـ STEM،
+
+594
+00:57:41,310 --> 00:57:44,930
+خلّيني نرجع للقبل كـ Pharmaceutical researcher
+
+595
+00:57:44,930 --> 00:57:49,330
+develops a new drug that affects bacterial protein
+
+596
+00:57:49,330 --> 00:57:55,350
+synthesis in an experiment الـ E coli was exposed
+
+597
+00:57:55,350 --> 00:57:59,330
+to that drug and serially cultured in media tagged
+
+598
+00:57:59,330 --> 00:58:03,840
+nucleotides and amino acidsيعني كل هذا الكلام يعني
+
+599
+00:58:03,840 --> 00:58:08,000
+بيشرحلك ال .. شو اسمه؟ ال .. الاشي ال .. ال ..
+
+600
+00:58:08,000 --> 00:58:12,120
+يعني السيناريو زي اللي اتكلمنا قبل شوية عن الـ
+
+601
+00:58:12,120 --> 00:58:15,000
+Recombinant DNA Technology بيشرحلك كيف انهم
+
+602
+00:58:15,000 --> 00:58:18,340
+بيعملوها للأيام هذه It is found that the drug
+
+603
+00:58:18,340 --> 00:58:22,920
+inhibits molecules that recognize the heightened
+
+604
+00:58:22,920 --> 00:58:27,220
+codon in the bacterial messenger RNA fragment
+
+605
+00:58:27,220 --> 00:58:30,700
+shown in the image below ماشي، which of the
+
+606
+00:58:30,700 --> 00:58:39,770
+following molecules isبالتأكيد، الهدف هو الـ
+
+607
+00:58:39,770 --> 00:59:00,650
+UUA اللي هو جسمهم أنا آسف، طلع السؤال ماشي،
+
+608
+00:59:00,650 --> 00:59:02,150
+الـ
+
+609
+00:59:07,510 --> 00:59:14,410
+بالنسبة لـ Heightened Codon in the bacterial RNA
+
+610
+00:59:14,410 --> 00:59:20,710
+fragment shown in the image below فالشيء
+
+611
+00:59:20,710 --> 00:59:24,250
+اللي هو هنا بيحاول، إحنا عكس اللي حكيناه من قبل
+
+612
+00:59:24,250 --> 00:59:32,340
+قبل شوية مثال إنه أناعندي بروتين أجى فيه الـ Stop
+
+613
+00:59:32,340 --> 00:59:39,680
+codon بشكل نتيجة الـ mutation وبيطلع عندي البروتين
+
+614
+00:59:39,680 --> 00:59:47,520
+أقل، ماشي أو البروتين طلع، شو اسمه، مش موجود، يعني
+
+615
+00:59:47,520 --> 00:59:53,320
+البروتين أنا طيرته، طيرت جزء منه، وبالتالي طلع ليه
+
+616
+00:59:53,320 --> 00:59:56,040
+قصير، فالآن
+
+617
+01:00:00,700 --> 01:00:09,380
+بالنسبة له حاطة وانا الـ UAA أو ال .. ال .. ال ..
+
+618
+01:00:09,380 --> 01:00:19,500
+ال .. شو اسمه؟ ليش هيك بيصير؟
+
+619
+01:00:19,500 --> 01:00:25,780
+ال
+
+620
+01:00:25,780 --> 01:00:32,390
+..مثلًا، أي واحد من الموليكيول المتواجد في هذه
+
+621
+01:00:32,390 --> 01:00:38,530
+الدروك؟ اللي هو الـCharged RNA، أو الـTransferable
+
+622
+01:00:38,530 --> 01:00:43,830
+RNA، ما لهاش معنى، يعني هون اللي بيقولوا، هاي
+
+623
+01:00:43,830 --> 01:00:47,770
+الـSegment بهذا الشكل، وين ما هي موجودة، ويكون
+
+624
+01:00:47,770 --> 01:00:54,010
+عندي إشي غير هذا، بتحطه، بتصير هذا موجود، ماشي،
+
+625
+01:00:54,360 --> 01:01:02,680
+فالفكرة أني أنا، شو اسمه؟ يعني خلّيت stop codon
+
+626
+01:01:02,680 --> 01:01:08,900
+تيجي، ماشي؟ فالـ which of the following molecules
+
+627
+01:01:08,900 --> 01:01:15,680
+is the most likely target of this drug؟ الشو
+
+628
+01:01:15,680 --> 01:01:22,470
+اسمه؟ يعني هو أنا اللي بحكيلكم إياه، إنهبما إنه
+
+629
+01:01:22,470 --> 01:01:28,110
+أنا عندي 64 كودون الـ Triplets هدولة الاحتمالات 64
+
+630
+01:01:28,110 --> 01:01:34,170
+إنه 4×4×4 وعندي 20 Amino Acids كل Amino Acid اللي
+
+631
+01:01:34,170 --> 01:01:41,270
+أكثر، اللي له أكثر من كودون فالـ GUU والـ GUC والـ
+
+632
+01:01:41,270 --> 01:01:48,510
+GUA والـ GUG كلهم بيعملوا الـ Valine هدولة يعني لو
+
+633
+01:01:48,510 --> 01:01:52,400
+صار بينهمالـ Single Nucleotide بوليموفيزم ما راح
+
+634
+01:01:52,400 --> 01:01:56,940
+يتأثر البروتين على مستوى الـ DNA اختلف، صحيح، بس
+
+635
+01:01:56,940 --> 01:02:02,200
+مستوى البروتين ما راح يختلف يعني ما إله هالـ SNP
+
+636
+01:02:02,200 --> 01:02:07,740
+وظيفة أو تأثير فيه إيش اسمه Termination of Protein
+
+637
+01:02:07,740 --> 01:02:11,900
+Synthesis اللي هم الـ Stop Codons اللي هم UUAA
+
+638
+01:02:11,900 --> 01:02:22,540
+وUAG وUGA ماشي، الـ Stop Codon هذهماشي ما إلها
+
+639
+01:02:22,540 --> 01:02:27,380
+يعني راح يكون الـ amino acid راح يتدخله لما تصير
+
+640
+01:02:27,380 --> 01:02:33,640
+هذه الشغلة النتيجة بتصير إنه هذا بيخلي البروتين
+
+641
+01:02:33,640 --> 01:02:42,400
+يعني يطلع أو بيخلي البروتين ينفصل عن الـ ribosome
+
+642
+01:02:42,400 --> 01:02:47,640
+وينفصل عن الـ الـ machinery تبع صناعة البروتين
+
+643
+01:02:47,640 --> 01:02:52,530
+وبالتالي بيسموه releasing factorماشي، هي القطعة أو
+
+644
+01:02:52,530 --> 01:03:01,170
+النقطة اللي راح تكون لما يعني تنصاب بيظل يكمل أو
+
+645
+01:03:01,170 --> 01:03:05,470
+إذا أجت في نص إشي مطلوب راح تخليه يوقف هنا فكلها
+
+646
+01:03:05,470 --> 01:03:10,290
+يعني هنا يعتبرون الـReleasing Factor فالإجابات
+
+647
+01:03:10,290 --> 01:03:15,210
+اللي حاطينها الـChoice A Charge Transferile RNA
+
+648
+01:03:15,210 --> 01:03:18,950
+Delivers Amino Acids to the Protein Synthesis
+
+649
+01:03:18,950 --> 01:03:27,460
+Complexماشي اللي هم يعني charged هنا بمعنى أنه الـ
+
+650
+01:03:27,460 --> 01:03:31,880
+Transferral RNA عليه الـ amino acid اللي بده يشبك
+
+651
+01:03:31,880 --> 01:03:35,620
+على الـ polypeptide chain الـ elongation factors
+
+652
+01:03:35,620 --> 01:03:39,720
+اللي هم facilitate الـ Transferral RNA binding to
+
+653
+01:03:39,720 --> 01:03:43,040
+the transcription steps in protein synthesis يعني
+
+654
+01:03:43,040 --> 01:03:48,360
+اللي هم بضيفاً الـ Transcription proteins pre-RNA
+
+655
+01:03:49,190 --> 01:03:52,650
+مسنجر RNA، موليكيول تحتوي على كثير من الـ Introns
+
+656
+01:03:52,650 --> 01:03:56,750
+وكثير من الـ Extrons يعني
+
+657
+01:03:56,750 --> 01:04:07,030
+هذه اللي هم يعني الـ RNA أول ما يطلع من البروتين،
+
+658
+01:04:07,030 --> 01:04:13,390
+بيكون مشبوك فيه، بيكون الـ pre-messenger RNA الـ
+
+659
+01:04:13,390 --> 01:04:18,630
+initiation of gene transcriptionسيها سهيل إجابة
+
+660
+01:04:18,630 --> 01:04:22,710
+اللي هي releasing factor لأن هذا stop codon يعني
+
+661
+01:04:22,710 --> 01:04:30,890
+وظيفة الـ stop codon حتى يبطل يسوي translation حتى
+
+662
+01:04:30,890 --> 01:04:39,050
+يبطل يعمل translation وبالتالي يوقف بناء البروتين
+
+663
+01:04:39,050 --> 01:04:45,220
+عند هذه النقطة، ماشي؟فهدولة يعني أسئلة شو اسمه؟
+
+664
+01:04:45,220 --> 01:04:49,340
+يعني في نقطة المهم يعني أنا بتوقع إن الواحد يتذكر
+
+665
+01:04:49,340 --> 01:04:55,320
+إن الـUAA طبعاً هنا الـComplementary
+
+666
+01:04:55,320 --> 01:05:02,960
+لأنه الـStop Codon اللي هو الـUAA والـUAG وUGA
+
+667
+01:05:04,000 --> 01:05:08,700
+«أرستوبكودونز» هؤلاء الذكروهم يعني إذا بدي إشي
+
+668
+01:05:08,700 --> 01:05:13,600
+عشان تعرفه تجاوب وأسئلة إذا في سؤال بالأخير جابلك
+
+669
+01:05:13,600 --> 01:05:19,160
+إنه هاي أجاب واحد من هذولة الثلاثة اعرف إنه فيه
+
+670
+01:05:19,160 --> 01:05:24,760
+يعني توقيف أو توقيف يمكن يسبب مرض إنه في نص إشي
+
+671
+01:05:24,760 --> 01:05:31,210
+مطلوب أو يسبب مرض إنهالمفروض أن البروتين الطبيعي
+
+672
+01:05:31,210 --> 01:05:35,890
+يكون هالجدّة وتكون هنا stop codon مش موجودة فتطلع
+
+673
+01:05:35,890 --> 01:05:39,530
+البروتين أطول مش هو اللي أنا بديها، فبدأت تاخدها
+
+674
+01:05:39,530 --> 01:05:48,430
+هيك، ماشي؟ دكتور شوف سؤال 14، برنامج؟ طيب، احكي،
+
+675
+01:05:48,430 --> 01:05:56,470
+اقرأ النية قبل ما أوصله، طيب
+
+676
+01:06:00,210 --> 01:06:06,350
+«طفولة مولودة لأمرأة عمرها 34 عامة لديها صورة
+
+677
+01:06:06,350 --> 01:06:10,870
+رسمية بطيئة» ما
+
+678
+01:06:10,870 --> 01:06:19,410
+هو اسمه؟ يعني أيش الحالة اللي بتتكلم عنها؟
+
+679
+01:06:23,480 --> 01:06:27,760
+«ترايزومي 21» «ترايزومي 21»، صحيح، ماشي، ففيه Flat
+
+680
+01:06:27,760 --> 01:06:31,860
+Facial Profile Prominent Epicanthal Fold زي تبعات
+
+681
+01:06:31,860 --> 01:06:35,740
+العيون بتخليهم زي الصينيين A Holocystolic Murmur
+
+682
+01:06:35,740 --> 01:06:38,860
+Heard Loudest at the Left External Border، بيكون
+
+683
+01:06:38,860 --> 01:06:42,440
+Congelital Heart Disease VSD ولا كده وهذا بتتصير
+
+684
+01:06:42,440 --> 01:06:47,140
+الـKaryotype Analysis is consistent with Trisomy
+
+685
+01:06:47,140 --> 01:06:47,660
+21
+
+686
+01:06:50,160 --> 01:06:54,960
+ماشي، maternal and paternal karyotypes are normal
+
+687
+01:06:54,960 --> 01:06:59,620
+الـ karyotype analysis consisted with الـ Trisomy
+
+688
+01:06:59,620 --> 01:07:05,780
+21 عند مين يا دكتور معتزجي؟ عند ال maternal؟ لأ
+
+689
+01:07:08,700 --> 01:07:15,680
+هو عند الطفل المصاب عنده
+
+690
+01:07:15,680 --> 01:07:21,280
+نفسه هو إتلاقينا الـ Trisomy 21 السجينة فحصنا أمه
+
+691
+01:07:21,280 --> 01:07:26,720
+وأبوه طلعوا Normal طلعوا Normal، ماشي A restricted
+
+692
+01:07:26,720 --> 01:07:31,820
+fragment-length polymorphism analysis is conducted
+
+693
+01:07:31,820 --> 01:07:35,600
+to determine the parental origin of the extra
+
+694
+01:07:35,600 --> 01:07:41,610
+chromosomeيعني شو اللي عملوه هنا؟ هذه واحدة من الـ
+
+695
+01:07:41,610 --> 01:07:47,230
+Restriction Fragment Length Polymorphism الـ
+
+696
+01:07:47,230 --> 01:07:54,250
+Restriction Enzyme هو إنزايم ماشي بيقطع الـ DNA في
+
+697
+01:07:54,250 --> 01:08:01,190
+أماكن محددة يعني إله قطعة معينة إذا شافها وقوم هيك
+
+698
+01:08:01,190 --> 01:08:07,550
+بنصها بيقطع الـ DNA فبنتج عن الموضوع هذا إنهكيف
+
+699
+01:08:07,550 --> 01:08:13,050
+يعني بنستفيد من هذه الخاصية أنه أنا لما نقطع بهذا
+
+700
+01:08:13,050 --> 01:08:20,650
+المكان راح ينتج عندي مجموعة قطع أطوالها مختلفة بين
+
+701
+01:08:20,650 --> 01:08:29,470
+الناس فاهم عليك كيف؟ فالآن يعني كيف أعرف إنه قطع
+
+702
+01:08:29,470 --> 01:08:37,070
+أطوالها مختلفة؟ إنه باجي بعمل Electrophoresisماشي،
+
+703
+01:08:37,070 --> 01:08:40,410
+فلما أسول Electrophoresis مين اللي بيظل عند
+
+704
+01:08:40,410 --> 01:08:46,470
+الـOrigin أو بطيء، بيكون الإثقال الإكبار والصغار
+
+705
+01:08:46,470 --> 01:08:55,130
+الإخفاف بيطيروا لقدام كثير، واضح؟ تمام فالآن، اللي
+
+706
+01:08:55,130 --> 01:09:01,250
+عملوا هذه النوع من الدراسة اللي هي Restriction,
+
+707
+01:09:01,370 --> 01:09:05,480
+Fragment, Length, Polymorphismالتحقق في تحقيق الـ
+
+708
+01:09:05,480 --> 01:09:10,500
+Lithopoiebolism كان يتم تحقيقه لتحقق أصل الأطفال
+
+709
+01:09:10,500 --> 01:09:15,440
+لـ Extra Chromosome يعني أجوا وعملوا الدراسة هذه
+
+710
+01:09:15,440 --> 01:09:21,420
+لجنين المصاب على طفل المصاب والأب والأم عشان
+
+711
+01:09:21,420 --> 01:09:28,420
+يشوفوا من أين أخذ المرض هذا، تمام؟ماشي الحال؟
+
+712
+01:09:28,420 --> 01:09:32,340
+أمامك الله الـ DNA samples from the child mother
+
+713
+01:09:32,340 --> 01:09:36,460
+and father were obtained and the DNA is fragmented
+
+714
+01:09:36,460 --> 01:09:39,860
+with restriction enzyme the fragments are then
+
+715
+01:09:39,860 --> 01:09:44,500
+stored sorted يعني عملنا Electrophoresis by size
+
+716
+01:09:44,500 --> 01:09:48,860
+using southern blot technique ال southern blot هذا
+
+717
+01:09:48,860 --> 01:09:52,280
+نوعية بعد ما تعمل انت Electrophoresis ما بتقدر
+
+718
+01:09:52,280 --> 01:09:57,120
+تشوفهمفبتجيب بعد ما تعمل الـ Electrophoresis بتحط
+
+719
+01:09:57,120 --> 01:10:02,760
+عليها طبقة ثانية وبتسمحله يصير Blocking يعني طبق
+
+720
+01:10:02,760 --> 01:10:09,380
+وبتشوف أين أجى المكان تبعه فـ Labeling is done
+
+721
+01:10:09,380 --> 01:10:12,700
+using a probe that binds to a specific DNA
+
+722
+01:10:12,700 --> 01:10:16,700
+sequence close to the centromere of chromosome 21
+
+723
+01:10:16,700 --> 01:10:23,190
+The Repelif Analysisof the child mother is shown
+
+724
+01:10:23,190 --> 01:10:27,590
+below فهيكي شكله الـ mother هيكي ال father هيكي
+
+725
+01:10:27,590 --> 01:10:34,110
+وال child هيكي هذولة يعني مكان وين الـ centromere
+
+726
+01:10:34,110 --> 01:10:41,030
+تبع chromosome 21 موجود في كل واحد منهم ماشي ال
+
+727
+01:10:41,030 --> 01:10:45,930
+mother القناها الثنتين هذولة ال father القناها
+
+728
+01:10:45,930 --> 01:10:51,870
+بالثنتين هذولة ال child عنده هذولة الثلاثةماشي،
+
+729
+01:10:51,870 --> 01:10:55,730
+اذا شو اللي صار عند هذا الطفل؟ المشكلة عند أبوه
+
+730
+01:10:55,730 --> 01:11:02,850
+ولا أمه يا معتز؟ عنده Trisomy 21، يعني ماياخد two
+
+731
+01:11:02,850 --> 01:11:07,770
+copies من واحد وماياخد copy واحد من شخص تاني، من
+
+732
+01:11:07,770 --> 01:11:12,250
+من من، تتوقع من من المشكلة؟ من الأم أخد two copies
+
+733
+01:11:12,250 --> 01:11:16,750
+من الأم أخدتنتين، تفهم علي؟فهو من الأم ماخد ثنتين
+
+734
+01:11:16,750 --> 01:11:20,970
+ومن الأب ماخد واحدة الأب هاي واحدة بس فذولا ثنتين
+
+735
+01:11:20,970 --> 01:11:27,790
+تبعت الأم من بينات عنده فهو هنا المشكلة في الأم
+
+736
+01:11:27,790 --> 01:11:35,410
+ماشي الحال شو اسمه؟ سؤال Which of the following
+
+737
+01:11:35,410 --> 01:11:42,390
+meiosis events did this non-discussion most likely
+
+738
+01:11:42,390 --> 01:11:47,990
+occur؟طبعًا الـ maternal غلط استفنناهم استفنناهم
+
+739
+01:11:47,990 --> 01:11:53,190
+الـ maternal meiosis one or two قدرت حيرت فيها
+
+740
+01:11:53,190 --> 01:11:56,530
+عشانك أنا سألت السؤال يعني ما احنا جولنا إنه ممكن
+
+741
+01:11:56,530 --> 01:12:02,370
+تصير في واحد أو في اتنين لأ الواحد شو المطلوب
+
+742
+01:12:02,370 --> 01:12:11,450
+يصير؟ الواحد مش أنت يعني أنت تفهم الـ step الأولى
+
+743
+01:12:11,450 --> 01:12:18,250
+بالـ meiosisبكون عندي الـ «أنا بسوي بالأول S
+
+744
+01:12:18,250 --> 01:12:19,550
+-phase» «أنا بسوي بالأول S-phase» «أنا بسوي بالأول
+
+745
+01:12:19,550 --> 01:12:20,130
+S-phase» «أنا بسوي بالأول S-phase» «أنا بسوي
+
+746
+01:12:20,130 --> 01:12:22,550
+بالأول S-phase» «أنا بسوي بالأول S-phase» «أنا
+
+747
+01:12:22,550 --> 01:12:23,610
+بسوي بالأول S-phase» «أنا بسوي بالأول S-phase»
+
+748
+01:12:23,610 --> 01:12:23,810
+«أنا بسوي بالأول S-phase» «أنا بسوي بالأول S
+
+749
+01:12:23,810 --> 01:12:23,830
+-phase» «أنا بسوي بالأول S-phase» «أنا بسوي بالأول
+
+750
+01:12:23,830 --> 01:12:27,170
+بالأول S-phase» «أنا بسوي بالأول S-phase» «أنا
+
+751
+01:12:27,170 --> 01:12:37,870
+بسوي بالأول S-phase» «أنا بسوي بالأول Sتنسم
+
+752
+01:12:37,870 --> 01:12:41,070
+الأثنين إلى واحد وواحد إلى واحد وواحد، فوين راح
+
+753
+01:12:41,070 --> 01:12:45,430
+تكون المشكلة؟ أنا بظن متين الـBiosis 2، شو كتب
+
+754
+01:12:45,430 --> 01:12:50,230
+الإجابة؟ وكتب واحد،
+
+755
+01:12:50,230 --> 01:12:58,050
+هاي فلأ، هحطها زي ما هم حكوا، أنا مش يعني، شو
+
+756
+01:12:58,050 --> 01:13:01,810
+اسمه؟ أتبروها، ليش طب مش أثنين؟
+
+757
+01:13:09,600 --> 01:13:21,080
+أه هنا الـ 2N ماشي الـ 2N اللي انفصلوا هم الـ
+
+758
+01:13:21,080 --> 01:13:26,500
+chromatids يعني نصي الكروموزوم بيصير انفصلوا،
+
+759
+01:13:26,500 --> 01:13:32,940
+ماشي؟ فزي ما هم حاطيه لكي هنا الأصل أنه الـ non
+
+760
+01:13:32,940 --> 01:13:38,130
+-disjunction in meiosis في الـ meiosis Iالأصل الـ
+
+761
+01:13:38,130 --> 01:13:43,870
+Normal إن يكون ينقسموا هيك وهيك ماشي، هذولة الـ
+
+762
+01:13:43,870 --> 01:13:49,090
+two copies from the same chromosome بنقسموا بحيث
+
+763
+01:13:49,090 --> 01:13:51,350
+يكون one chromosome هنا و one chromosome هنا
+
+764
+01:13:51,350 --> 01:13:56,560
+وبعدين بنفصل بهذا الشكلإذا كان الـ Non-Disjunction
+
+765
+01:13:56,560 --> 01:13:59,960
+ممكن يكون في الـ Meiosis I وممكن يكون في الـ
+
+766
+01:13:59,960 --> 01:14:05,560
+Meiosis II وهنا صار Non-Disjunction وهنا الـ Step
+
+767
+01:14:05,560 --> 01:14:07,060
+الأولى Non-Disjunction
+
+768
+01:14:10,560 --> 01:14:13,260
+الـNon-disjunction هي خسارة كروموزوم الممكن أن
+
+769
+01:14:13,260 --> 01:14:16,380
+تتفرق بشكل صحيح خلال تقسيم الجسم، هذا يمكن أن يكون
+
+770
+01:14:16,380 --> 01:14:20,720
+بسبب خسارة كروموزوم متعاملة لتفرق في ميوزوس 1 أو
+
+771
+01:14:20,720 --> 01:14:27,580
+خسارة أختي كروموتيد لتفرق في ميوزوس 2 أو ميتوسس،
+
+772
+01:14:27,580 --> 01:14:31,460
+في الـMonosomy، خسارة كروموزوم متعاملة في
+
+773
+01:14:31,460 --> 01:14:34,520
+الـTrisomy، خسارة كروموزوم متعاملة في الـGain،
+
+774
+01:14:34,520 --> 01:14:37,020
+الـMonosomy أو الـTrisomy بإمكانها أن تنتج من
+
+775
+01:14:37,020 --> 01:14:44,310
+مجموعة واحدة أو اثنين،طيب وبعدين non-disjunction
+
+776
+01:14:44,310 --> 01:14:47,510
+is a failure of chromosome pairs to separate this
+
+777
+01:14:47,510 --> 01:14:53,590
+could be failure of طب ما حكيناها shows that both
+
+778
+01:14:53,590 --> 01:14:57,230
+parents demonstrate two bands each parental band
+
+779
+01:14:57,230 --> 01:15:01,170
+represents a homologous chromosome 21 this child
+
+780
+01:15:01,170 --> 01:15:08,020
+has three bandsاللي فهمته يا دكتوره إنه في الـ
+
+781
+01:15:08,020 --> 01:15:12,340
+Meiosis 1 الكروموسومات بتنفصل على بعض أما في الـ
+
+782
+01:15:12,340 --> 01:15:16,560
+Meiosis 2 الكروماتيد هي اللي بتنفصل صحيح، صحيح هو
+
+783
+01:15:16,560 --> 01:15:21,580
+بيقول لك الـTrisomy 21 هو الكروموسوم ما نفصلش عشان
+
+784
+01:15:21,580 --> 01:15:25,340
+هيك في Meiosis 1؟ therefore the problem occurred
+
+785
+01:15:25,340 --> 01:15:29,120
+in the mother during Meiosis 1 when homolysis
+
+786
+01:15:29,120 --> 01:15:34,670
+chromosomes are separated صحيح، تمامماشي واضحة
+
+787
+01:15:34,670 --> 01:15:41,490
+الآن يا ماتز؟ تمام، سؤال 16 كمان عن الـ
+
+788
+01:15:41,490 --> 01:15:50,610
+Electrophoresis بعد أن هم مجلوبين طيب،
+
+789
+01:15:50,610 --> 01:15:54,310
+a 26-year-old woman comes to the office with her
+
+790
+01:15:54,310 --> 01:15:57,610
+husband for genetic counseling she's pregnant with
+
+791
+01:15:57,610 --> 01:16:01,650
+their second child whose gender is unknownمثلًا،
+
+792
+01:16:01,650 --> 01:16:05,550
+كلا الأطفال مميزين بشكل كام، وكانوا أولاً يولدوا
+
+793
+01:16:05,550 --> 01:16:09,090
+أولاً أبنة عمره ثلاث عامًا، وكان لديه حالات مستمرة
+
+794
+01:16:09,090 --> 01:16:14,310
+من الانيميا، الجوندس، وشعور مؤلم من يده وعينيه،
+
+795
+01:16:14,310 --> 01:16:16,250
+وكانت مجموعة دم من الفتى
+
+796
+01:16:16,250 --> 01:16:19,310
+والهيموجلوبينالكتروفوريسيس
+
+797
+01:16:19,310 --> 01:16:22,510
+تم تجاربها في مجال الـAlkaline pH، وهي الميزات
+
+798
+01:16:22,510 --> 01:16:24,770
+المظهرة هنا
+
+799
+01:16:36,520 --> 01:16:42,120
+هه؟ الـ Hemoglobin S يعني Sickle Cell Disease
+
+800
+01:16:42,120 --> 01:16:49,040
+الأنيميا والـ Jaundice ماشي ماعرفش ليش الـ
+
+801
+01:16:49,040 --> 01:16:55,420
+swellings of the hands and feet السبب فالـ بالنسبة
+
+802
+01:16:55,420 --> 01:17:00,000
+له في الحالة هذه بكون
+
+803
+01:17:00,000 --> 01:17:02,020
+شو اسمه؟
+
+804
+01:17:08,300 --> 01:17:12,880
+عملوا Hemoglobin Electrophoresis هنا فالـ
+
+805
+01:17:12,880 --> 01:17:19,860
+Hemoglobin A مش موجود هذا لمين؟ للطفل المصاب، صح؟
+
+806
+01:17:19,860 --> 01:17:24,080
+Blood sample is obtained from the boy and
+
+807
+01:17:24,080 --> 01:17:27,260
+Hemoglobin Electrophoresis is performed at
+
+808
+01:17:27,260 --> 01:17:33,800
+alkaline pH، ماشي الحال، فكل الـ Hemoglobin تبعه
+
+809
+01:17:34,820 --> 01:17:39,280
+ماشي، Hemoglobin S يعني مافيش Hemoglobin A ولا
+
+810
+01:17:39,280 --> 01:17:46,060
+Hemoglobin F اللي بيخفف وكله Hemoglobin S، تمام؟
+
+811
+01:17:46,060 --> 01:17:49,400
+فالآن السؤال What is the probability that the
+
+812
+01:17:49,400 --> 01:17:53,800
+unborn child will inherit one or more mutant
+
+813
+01:17:53,800 --> 01:17:57,940
+alleles from his parents؟ فشو هذا الـ Disease يا
+
+814
+01:17:57,940 --> 01:18:03,700
+معتز؟زي ما مدرسي يسأل؟ طيب، إذا أقرأ السؤال بشكل
+
+815
+01:18:03,700 --> 01:18:08,700
+دقيق، شو نسبت إن الـ Probability الـ unborn child
+
+816
+01:18:08,700 --> 01:18:13,200
+will inherit one or more؟ يعني المواحد يعني ما
+
+817
+01:18:13,200 --> 01:18:17,180
+إتنين، القليل اللي هم الـ mutant طيب، إذا شو
+
+818
+01:18:17,180 --> 01:18:24,240
+نسبهم؟ تلت أربعة تلت أربعة، هيك المفروض تلت
+
+819
+01:18:24,240 --> 01:18:31,020
+أربعة، ماشي؟السبب أنه فيه احتمال ربع هذا تظامن
+
+820
+01:18:31,020 --> 01:18:35,520
+recessive وإحنا نحكي على الطفل اللي مش مولود لسه
+
+821
+01:18:35,520 --> 01:18:42,280
+لو حكى one قليل mutant بيكون نص صح؟ لو one قليل
+
+822
+01:18:42,280 --> 01:18:48,700
+only أه كان لو حكى هيكي بس حكى one or more لو two
+
+823
+01:18:48,700 --> 01:18:54,140
+قليل برضه بيطلع ربع لو two قليل بيطلع ربع صحيحماشي
+
+824
+01:18:54,140 --> 01:18:57,880
+أنا مضطر هسأطلع أترككم لإنه عندي تدريس تاني يا
+
+825
+01:18:57,880 --> 01:19:01,980
+شباب، ماشي نلتقى يوم الإثنان الجاي إن شاء الله
+
+826
+01:19:01,980 --> 01:19:05,320
+يعطيك ألف عافية يا دكتور الله يحييكم، الله يحفظكم،
+
+827
+01:19:05,320 --> 01:19:08,540
+أهلين، أهلين، يالا السلام عليكم في رعاية الله
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Y-q_VMv635w_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Y-q_VMv635w_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..03ee5cf4566acfb571a9f17c27c672aaa89095ac
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Y-q_VMv635w_raw.json
@@ -0,0 +1 @@
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"end": 327.84, "word": " Problem", "probability": 0.70556640625}, {"start": 327.84, "end": 330.22, "word": " وهي", "probability": 0.71533203125}, {"start": 330.22, "end": 330.64, "word": " كلها", "probability": 0.9794921875}, {"start": 330.64, "end": 331.02, "word": " ماشي", "probability": 0.83447265625}, {"start": 331.02, "end": 331.4, "word": " مؤشر", "probability": 0.9392903645833334}, {"start": 331.4, "end": 331.7, "word": " على", "probability": 0.94482421875}, {"start": 331.7, "end": 332.7, "word": " Hemophilia", "probability": 0.8916015625}], "temperature": 1.0}, {"id": 13, "seek": 36267, "start": 333.21, "end": 362.67, "text": "طبعاً الـ Hemophilia فيه Hemophilia A و Hemophilia B الـ Hemophilia A اللي هو الـ Factor 8 Deficiency Hemophilia B اللي هي Factor 9 اللي بيسموها Christmas Disease اللي هي اسم تاني كل هذه المعلومات هيك بتيجي من الأول يعني إنسان أو طفل أو ذكر عنده Hemophilia A هاي الكلام اللي بيبقوا لكي يعني الآن", "tokens": [9566, 3555, 3615, 995, 14111, 2423, 39184, 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{"start": 333.73, "end": 334.15, "word": " Hemophilia", "probability": 0.815185546875}, {"start": 334.15, "end": 334.47, "word": " فيه", "probability": 0.6865234375}, {"start": 334.47, "end": 335.07, "word": " Hemophilia", "probability": 0.9222005208333334}, {"start": 335.07, "end": 335.37, "word": " A", "probability": 0.8330078125}, {"start": 335.37, "end": 335.81, "word": " و", "probability": 0.93701171875}, {"start": 335.81, "end": 336.67, "word": " Hemophilia", "probability": 0.88525390625}, {"start": 336.67, "end": 337.05, "word": " B", "probability": 0.99365234375}, {"start": 337.05, "end": 337.77, "word": " الـ", "probability": 0.880859375}, {"start": 337.77, "end": 338.23, "word": " Hemophilia", "probability": 0.93798828125}, {"start": 338.23, "end": 338.55, "word": " A", "probability": 0.9931640625}, {"start": 338.55, "end": 338.77, "word": " اللي", "probability": 0.88916015625}, {"start": 338.77, "end": 338.93, "word": " هو", "probability": 0.99072265625}, {"start": 338.93, 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377.63, "word": " هاي", "probability": 0.668701171875}, {"start": 377.63, "end": 378.57, "word": " لو", "probability": 0.91748046875}, {"start": 378.57, "end": 379.11, "word": " كان", "probability": 0.99560546875}, {"start": 379.11, "end": 380.65, "word": " autosomal", "probability": 0.76416015625}, {"start": 380.65, "end": 381.49, "word": " recessive", "probability": 0.7392578125}, {"start": 381.49, "end": 383.07, "word": " ما", "probability": 0.7685546875}, {"start": 383.07, "end": 383.91, "word": " بتثبت", "probability": 0.829833984375}, {"start": 383.91, "end": 384.79, "word": " كان", "probability": 0.896484375}, {"start": 384.79, "end": 385.95, "word": " لازم", "probability": 0.9908854166666666}, {"start": 385.95, "end": 386.23, "word": " يكون", "probability": 0.987548828125}, {"start": 386.23, "end": 386.51, "word": " both", "probability": 0.8818359375}, {"start": 386.51, "end": 386.77, "word": " his", "probability": 0.544921875}, {"start": 386.77, "end": 387.29, "word": " parents", "probability": 0.8134765625}, {"start": 387.29, "end": 387.71, "word": " are", "probability": 0.91455078125}, {"start": 387.71, "end": 388.83, "word": " recessive", "probability": 0.936279296875}, {"start": 388.83, "end": 389.45, "word": " are", "probability": 0.36572265625}, {"start": 389.45, "end": 389.89, "word": " carriers", "probability": 0.853515625}, {"start": 389.89, "end": 391.23, "word": " ماشي", "probability": 0.8849283854166666}], "temperature": 1.0}, {"id": 15, "seek": 41649, "start": 392.07, "end": 416.49, "text": "فهذه إلا تكون X-linked recessive والـ Career بالـ Parents هي الأم، ماشي؟ أسا عنده أخت who does not have this condition is pregnant يعني أسا أخته يعني الـ Hallmark دائما بنقول أو العلام المميزة", "tokens": [5172, 3224, 24192, 11933, 15040, 6055, 30544, 1783, 12, 22473, 292, 850, 442, 488, 16070, 39184, 31690, 20666, 39184, 33990, 39896, 16247, 2304, 12399, 3714, 33599, 1829, 22807, 5551, 3794, 995, 43242, 3224, 5551, 46456, 567, 775, 406, 362, 341, 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396.57, "word": " بالـ", "probability": 0.295166015625}, {"start": 396.57, "end": 396.87, "word": " Parents", "probability": 0.548828125}, {"start": 396.87, "end": 397.13, "word": " هي", "probability": 0.95947265625}, {"start": 397.13, "end": 398.51, "word": " الأم،", "probability": 0.7823893229166666}, {"start": 398.51, "end": 400.65, "word": " ماشي؟", "probability": 0.888671875}, {"start": 400.65, "end": 401.39, "word": " أسا", "probability": 0.4517415364583333}, {"start": 401.39, "end": 401.79, "word": " عنده", "probability": 0.99169921875}, {"start": 401.79, "end": 402.19, "word": " أخت", "probability": 0.942138671875}, {"start": 402.19, "end": 404.43, "word": " who", "probability": 0.300048828125}, {"start": 404.43, "end": 404.89, "word": " does", "probability": 0.9677734375}, {"start": 404.89, "end": 405.79, "word": " not", "probability": 0.9716796875}, {"start": 405.79, "end": 406.27, "word": " have", "probability": 0.9658203125}, {"start": 406.27, "end": 406.67, "word": " this", "probability": 0.9404296875}, {"start": 406.67, "end": 407.29, "word": " condition", "probability": 0.97265625}, {"start": 407.29, "end": 408.33, "word": " is", "probability": 0.61328125}, {"start": 408.33, "end": 408.83, "word": " pregnant", "probability": 0.8544921875}, {"start": 408.83, "end": 410.23, "word": " يعني", "probability": 0.872802734375}, {"start": 410.23, "end": 410.57, "word": " أسا", "probability": 0.873046875}, {"start": 410.57, "end": 411.25, "word": " أخته", "probability": 0.9798177083333334}, {"start": 411.25, "end": 413.29, "word": " يعني", "probability": 0.803466796875}, {"start": 413.29, "end": 413.51, "word": " الـ", "probability": 0.87548828125}, {"start": 413.51, "end": 413.99, "word": " Hallmark", "probability": 0.748046875}, {"start": 413.99, "end": 414.29, "word": " دائما", "probability": 0.7137858072916666}, {"start": 414.29, "end": 414.85, "word": " بنقول", "probability": 0.787109375}, {"start": 414.85, "end": 415.15, "word": " أو", "probability": 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0.90869140625}, {"start": 1416.98, "end": 1417.36, "word": " ألف", "probability": 0.928955078125}, {"start": 1417.36, "end": 1417.56, "word": " اللي", "probability": 0.878173828125}, {"start": 1417.56, "end": 1417.8, "word": " هي", "probability": 0.93798828125}, {"start": 1417.8, "end": 1418.08, "word": " Q", "probability": 0.61376953125}, {"start": 1418.08, "end": 1418.76, "word": " تربيع", "probability": 0.80242919921875}, {"start": 1418.76, "end": 1420.68, "word": " ماشي", "probability": 0.8206380208333334}], "temperature": 1.0}, {"id": 52, "seek": 144984, "start": 1422.48, "end": 1449.84, "text": "الآن ما ستفعل؟ هي Carrier فإنه الأول طلع بهذا الشكل معناته إنه نصيبهم إن الشخص الثاني اللي أخذوا منه بشكل عمياني الـ Spare طلع عنده الـ Carrier للجين هذا", "tokens": [6027, 148, 48506, 19446, 8608, 2655, 5172, 30241, 22807, 39896, 2741, 7326, 6156, 28814, 1863, 3224, 16247, 12610, 23032, 1211, 3615, 39627, 15730, 25124, 28820, 20449, 8315, 47395, 36145, 3224, 8717, 9381, 1829, 3555, 16095, 36145, 25124, 9778, 9381, 6024, 104, 7649, 1829, 13672, 1829, 5551, 9778, 8848, 14407, 9154, 3224, 4724, 8592, 28820, 6225, 2304, 1829, 7649, 1829, 2423, 39184, 1738, 543, 23032, 1211, 3615, 43242, 3224, 2423, 39184, 2741, 7326, 24976, 7435, 9957, 23758], "avg_logprob": -0.22159090212413243, "compression_ratio": 1.5602409638554218, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1422.48, "end": 1423.82, "word": "الآن", "probability": 0.7525227864583334}, {"start": 1423.82, "end": 1424.08, "word": " ما", "probability": 0.39013671875}, {"start": 1424.08, "end": 1425.0, "word": " ستفعل؟", "probability": 0.569775390625}, {"start": 1425.0, "end": 1426.82, "word": " هي", "probability": 0.646484375}, {"start": 1426.82, "end": 1427.52, "word": " Carrier", "probability": 0.64599609375}, {"start": 1427.52, "end": 1430.6, "word": " فإنه", "probability": 0.62249755859375}, {"start": 1430.6, "end": 1431.28, "word": " الأول", "probability": 0.9873046875}, {"start": 1431.28, "end": 1431.86, "word": " طلع", "probability": 0.9523111979166666}, {"start": 1431.86, "end": 1432.26, "word": " بهذا", "probability": 0.96630859375}, {"start": 1432.26, "end": 1432.82, "word": " الشكل", "probability": 0.9931640625}, {"start": 1432.82, "end": 1434.14, "word": " معناته", "probability": 0.919921875}, {"start": 1434.14, "end": 1435.18, "word": " إنه", "probability": 0.67431640625}, {"start": 1435.18, "end": 1436.2, "word": " نصيبهم", "probability": 0.8732421875}, {"start": 1436.2, "end": 1437.04, "word": " إن", "probability": 0.6201171875}, {"start": 1437.04, "end": 1437.86, "word": " الشخص", "probability": 0.9640299479166666}, {"start": 1437.86, "end": 1438.52, "word": " الثاني", "probability": 0.970703125}, {"start": 1438.52, "end": 1438.76, "word": " اللي", "probability": 0.98388671875}, {"start": 1438.76, "end": 1439.2, "word": " أخذوا", "probability": 0.9141845703125}, {"start": 1439.2, "end": 1439.6, "word": " منه", "probability": 0.9892578125}, {"start": 1439.6, "end": 1440.2, "word": " بشكل", "probability": 0.9212239583333334}, {"start": 1440.2, "end": 1443.28, "word": " عمياني", "probability": 0.95771484375}, {"start": 1443.28, "end": 1443.94, "word": " الـ", "probability": 0.8544921875}, {"start": 1443.94, "end": 1444.5, "word": " Spare", "probability": 0.744384765625}, {"start": 1444.5, "end": 1446.02, "word": " طلع", "probability": 0.8639322916666666}, {"start": 1446.02, "end": 1446.82, "word": " عنده", "probability": 0.94580078125}, {"start": 1446.82, "end": 1447.2, "word": " الـ", "probability": 0.752685546875}, {"start": 1447.2, "end": 1447.54, "word": " Carrier", "probability": 0.818603515625}, {"start": 1447.54, "end": 1449.4, "word": " للجين", "probability": 0.7314453125}, {"start": 1449.4, "end": 1449.84, "word": " هذا", "probability": 0.97802734375}], "temperature": 1.0}, {"id": 53, "seek": 147701, "start": 1450.49, "end": 1477.01, "text": "وبالتالي autosome-recessive فواحد من هذا الـ 40 ألف طلع بهذا الطفل اللي عنده بالأول a different sperm donor is selected with no personal or family history of Bombay disease however his career status is unknown فقرروا المرة الثانية بيعدوا نفس الشغل بس المرة هذه قالوا خلينا ناخد حد ثاني فاخدوا شخص آخر", "tokens": [37746, 6027, 2655, 6027, 1829, 1476, 329, 423, 12, 265, 780, 488, 6156, 14407, 24401, 9154, 23758, 2423, 39184, 3356, 5551, 46538, 23032, 1211, 3615, 39627, 15730, 41950, 5172, 1211, 13672, 1829, 43242, 3224, 20666, 10721, 12610, 257, 819, 32899, 25493, 307, 8209, 365, 572, 2973, 420, 1605, 2503, 295, 25463, 320, 4752, 4461, 702, 3988, 6558, 307, 9841, 6156, 4587, 2288, 2288, 14407, 9673, 25720, 6024, 104, 7649, 10632, 4724, 1829, 22488, 14407, 8717, 36178, 25124, 17082, 1211, 4724, 3794, 9673, 25720, 29538, 50239, 14407, 16490, 20292, 8315, 8717, 47283, 3215, 11331, 3215, 38637, 7649, 1829, 6156, 47283, 3215, 14407, 13412, 9778, 9381, 19753, 34740], "avg_logprob": -0.2113025756639855, "compression_ratio": 1.4982332155477032, "no_speech_prob": 9.5367431640625e-07, "words": [{"start": 1450.49, "end": 1451.27, "word": "وبالتالي", "probability": 0.9421875}, {"start": 1451.27, "end": 1451.93, "word": " autosome", "probability": 0.5449625651041666}, {"start": 1451.93, "end": 1452.57, "word": "-recessive", "probability": 0.7166748046875}, {"start": 1452.57, "end": 1453.05, "word": " فواحد", "probability": 0.7616373697916666}, {"start": 1453.05, "end": 1453.21, "word": " من", "probability": 0.93896484375}, {"start": 1453.21, "end": 1453.39, "word": " هذا", "probability": 0.2081298828125}, {"start": 1453.39, "end": 1453.51, "word": " الـ", "probability": 0.541748046875}, {"start": 1453.51, "end": 1453.75, "word": " 40", "probability": 0.693359375}, {"start": 1453.75, "end": 1454.03, "word": " ألف", "probability": 0.942138671875}, {"start": 1454.03, "end": 1454.33, "word": " طلع", "probability": 0.94482421875}, {"start": 1454.33, "end": 1454.67, "word": " بهذا", "probability": 0.920654296875}, {"start": 1454.67, "end": 1455.03, "word": " الطفل", "probability": 0.9930013020833334}, {"start": 1455.03, "end": 1455.17, "word": " اللي", "probability": 0.97607421875}, {"start": 1455.17, "end": 1455.49, "word": " عنده", "probability": 0.890869140625}, {"start": 1455.49, "end": 1455.99, "word": " بالأول", "probability": 0.94873046875}, {"start": 1455.99, "end": 1457.93, "word": " a", "probability": 0.12298583984375}, {"start": 1457.93, "end": 1458.45, "word": " different", "probability": 0.912109375}, {"start": 1458.45, "end": 1458.95, "word": " sperm", "probability": 0.966796875}, {"start": 1458.95, "end": 1459.49, "word": " donor", "probability": 0.9755859375}, {"start": 1459.49, "end": 1459.95, "word": " is", "probability": 0.9443359375}, {"start": 1459.95, "end": 1460.49, "word": " selected", "probability": 0.89306640625}, {"start": 1460.49, "end": 1461.21, "word": " with", "probability": 0.884765625}, {"start": 1461.21, "end": 1461.51, "word": " no", "probability": 0.93603515625}, {"start": 1461.51, "end": 1462.11, "word": " personal", "probability": 0.90576171875}, {"start": 1462.11, "end": 1462.45, "word": " or", "probability": 0.4306640625}, {"start": 1462.45, "end": 1462.77, "word": " family", "probability": 0.91064453125}, {"start": 1462.77, "end": 1463.37, "word": " history", "probability": 0.8994140625}, {"start": 1463.37, "end": 1463.97, "word": " of", "probability": 0.916015625}, {"start": 1463.97, "end": 1464.35, "word": " Bombay", "probability": 0.852783203125}, {"start": 1464.35, "end": 1464.89, "word": " disease", "probability": 0.630859375}, {"start": 1464.89, "end": 1466.23, "word": " however", "probability": 0.84228515625}, {"start": 1466.23, "end": 1466.85, "word": " his", "probability": 0.767578125}, {"start": 1466.85, "end": 1467.21, "word": " career", "probability": 0.9482421875}, {"start": 1467.21, "end": 1467.85, "word": " status", "probability": 0.9580078125}, {"start": 1467.85, "end": 1468.09, "word": " is", "probability": 0.96337890625}, {"start": 1468.09, "end": 1468.49, "word": " unknown", "probability": 0.9443359375}, {"start": 1468.49, "end": 1469.89, "word": " فقرروا", "probability": 0.9791015625}, {"start": 1469.89, "end": 1470.23, "word": " المرة", "probability": 0.9443359375}, {"start": 1470.23, "end": 1470.65, "word": " الثانية", "probability": 0.9442138671875}, {"start": 1470.65, "end": 1471.31, "word": " بيعدوا", "probability": 0.554718017578125}, {"start": 1471.31, "end": 1471.55, "word": " نفس", "probability": 0.99462890625}, {"start": 1471.55, "end": 1472.07, "word": " الشغل", "probability": 0.9264322916666666}, {"start": 1472.07, "end": 1472.83, "word": " بس", "probability": 0.93798828125}, {"start": 1472.83, "end": 1473.15, "word": " المرة", "probability": 0.983154296875}, {"start": 1473.15, "end": 1473.41, "word": " هذه", "probability": 0.90185546875}, {"start": 1473.41, "end": 1474.23, "word": " قالوا", "probability": 0.931884765625}, {"start": 1474.23, "end": 1474.57, "word": " خلينا", "probability": 0.7350260416666666}, {"start": 1474.57, "end": 1474.89, "word": " ناخد", "probability": 0.9083658854166666}, {"start": 1474.89, "end": 1475.11, "word": " حد", "probability": 0.89111328125}, {"start": 1475.11, "end": 1475.77, "word": " ثاني", "probability": 0.94775390625}, {"start": 1475.77, "end": 1476.33, "word": " فاخدوا", "probability": 0.7880859375}, {"start": 1476.33, "end": 1476.63, "word": " شخص", "probability": 0.9986979166666666}, {"start": 1476.63, "end": 1477.01, "word": " آخر", "probability": 0.869140625}], "temperature": 1.0}, {"id": 54, "seek": 150707, "start": 1477.47, "end": 1507.07, "text": "بس برضه مش جادرين يكونوا متأكدين إنه ما عنده المرض وفي الغالب اللي بتبرع بهذه الشغلات يكون يفترض إنه هيك على الأقل مظهريًا إنه إنسان سليم وطبيعي وكذا وكذلك يعني، ماشي؟ So، الآن السؤال What is the probability of the patient having an affected child with the new sperm donor؟", "tokens": [3555, 3794, 4724, 43042, 3224, 37893, 10874, 18513, 2288, 9957, 7251, 30544, 14407, 44650, 10721, 4117, 3215, 9957, 36145, 3224, 19446, 43242, 3224, 9673, 43042, 4032, 41185, 6024, 118, 6027, 3555, 13672, 1829, 39894, 26890, 3615, 39627, 24192, 25124, 17082, 1211, 9307, 7251, 30544, 7251, 5172, 2655, 43042, 36145, 3224, 39896, 4117, 15844, 16247, 4587, 1211, 3714, 19913, 3224, 16572, 14111, 995, 36145, 3224, 36145, 3794, 7649, 8608, 20292, 2304, 4032, 9566, 21292, 3615, 1829, 4032, 4117, 15730, 4032, 4117, 8848, 23275, 37495, 22653, 12399, 3714, 33599, 1829, 22807, 407, 12399, 6024, 48506, 21136, 33604, 6027, 708, 307, 264, 8482, 295, 264, 4537, 1419, 364, 8028, 1440, 365, 264, 777, 32899, 25493, 22807], "avg_logprob": -0.20627741803202712, "compression_ratio": 1.5457875457875458, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1477.47, "end": 1477.81, "word": "بس", "probability": 0.633544921875}, {"start": 1477.81, "end": 1478.29, "word": " برضه", "probability": 0.9542643229166666}, {"start": 1478.29, "end": 1478.89, "word": " مش", "probability": 0.869140625}, {"start": 1478.89, "end": 1480.07, "word": " جادرين", "probability": 0.82452392578125}, {"start": 1480.07, "end": 1480.75, "word": " يكونوا", "probability": 0.9729817708333334}, {"start": 1480.75, "end": 1481.43, "word": " متأكدين", "probability": 0.96796875}, {"start": 1481.43, "end": 1481.67, "word": " إنه", "probability": 0.6990966796875}, {"start": 1481.67, "end": 1481.79, "word": " ما", "probability": 0.95751953125}, {"start": 1481.79, "end": 1482.05, "word": " عنده", "probability": 0.8994140625}, {"start": 1482.05, "end": 1482.47, "word": " المرض", "probability": 0.957275390625}, {"start": 1482.47, "end": 1483.23, "word": " وفي", "probability": 0.77392578125}, {"start": 1483.23, "end": 1483.63, "word": " الغالب", "probability": 0.9776611328125}, {"start": 1483.63, "end": 1483.77, "word": " اللي", "probability": 0.949462890625}, {"start": 1483.77, "end": 1484.29, "word": " بتبرع", "probability": 0.9593098958333334}, {"start": 1484.29, "end": 1484.57, "word": " بهذه", "probability": 0.8251953125}, {"start": 1484.57, "end": 1485.03, "word": " الشغلات", "probability": 0.9215087890625}, {"start": 1485.03, "end": 1485.51, "word": " يكون", "probability": 0.547119140625}, {"start": 1485.51, "end": 1486.45, "word": " يفترض", "probability": 0.9693603515625}, {"start": 1486.45, "end": 1486.97, "word": " إنه", "probability": 0.8310546875}, {"start": 1486.97, "end": 1487.33, "word": " هيك", "probability": 0.4991455078125}, {"start": 1487.33, "end": 1487.47, "word": " على", "probability": 0.96728515625}, {"start": 1487.47, "end": 1487.67, "word": " الأقل", "probability": 0.748046875}, {"start": 1487.67, "end": 1488.37, "word": " مظهريًا", "probability": 0.8387044270833334}, {"start": 1488.37, "end": 1488.73, "word": " إنه", "probability": 0.823974609375}, {"start": 1488.73, "end": 1489.21, "word": " إنسان", "probability": 0.96044921875}, {"start": 1489.21, "end": 1489.83, "word": " سليم", "probability": 0.9475911458333334}, {"start": 1489.83, "end": 1490.97, "word": " وطبيعي", "probability": 0.9775390625}, {"start": 1490.97, "end": 1492.01, "word": " وكذا", "probability": 0.935546875}, {"start": 1492.01, "end": 1492.57, "word": " وكذلك", "probability": 0.65802001953125}, {"start": 1492.57, "end": 1493.85, "word": " يعني،", "probability": 0.6221516927083334}, {"start": 1493.85, "end": 1494.77, "word": " ماشي؟", "probability": 0.8741455078125}, {"start": 1494.77, "end": 1495.95, "word": " So،", "probability": 0.27032470703125}, {"start": 1495.95, "end": 1496.23, "word": " الآن", "probability": 0.77734375}, {"start": 1496.23, "end": 1496.81, "word": " السؤال", "probability": 0.9876302083333334}, {"start": 1496.81, "end": 1497.99, "word": " What", "probability": 0.431396484375}, {"start": 1497.99, "end": 1498.27, "word": " is", "probability": 0.94189453125}, {"start": 1498.27, "end": 1498.45, "word": " the", "probability": 0.88330078125}, {"start": 1498.45, "end": 1499.11, "word": " probability", "probability": 0.95751953125}, {"start": 1499.11, "end": 1500.45, "word": " of", 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"end": 1535.16, "text": "الأن الأم اللي هي هاي بتسأل هي أكيد إيش؟ مصابة ولا career ولا طبيعي؟ ‏- career ‏- لازم تكون career، صح؟ ‏- لازم تكون career ‏- لازم تكون career ‏- لازم تكون career ‏- لازم تكون career ‏- لازم تكون career ‏- لازم تكون career ‏- لازم تكون career ‏- لازم تكون career ‏- لازم تكون career ‏- لازم تكون career ‏- لازم تكون career ‏- لازم تكون career ‏- لازم تكون career ‏- لازم تكون career ‏- لازم تكون career ‏- لازم تكون career ‏- لازم تكون career ‏- لازم تكون career ‏- لازم تكون career ‏-", "tokens": [6027, 33456, 16247, 2304, 13672, 1829, 39896, 8032, 47302, 39894, 3794, 10721, 1211, 39896, 5551, 4117, 25708, 11933, 1829, 8592, 22807, 3714, 9381, 16758, 3660, 49429, 3988, 49429, 23032, 21292, 3615, 1829, 22807, 1059, 237, 12, 3988, 1059, 237, 12, 5296, 31377, 2304, 6055, 30544, 3988, 12399, 20328, 5016, 22807, 1059, 237, 12, 5296, 31377, 2304, 6055, 30544, 3988, 1059, 237, 12, 5296, 31377, 2304, 6055, 30544, 3988, 1059, 237, 12, 5296, 31377, 2304, 6055, 30544, 3988, 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0.9259905133928571}, {"start": 2557.41, "end": 2558.13, "word": " أو", "probability": 0.93994140625}, {"start": 2558.13, "end": 2558.61, "word": " الـ", "probability": 0.75634765625}, {"start": 2558.61, "end": 2560.31, "word": " other", "probability": 0.52685546875}, {"start": 2560.31, "end": 2560.95, "word": " things", "probability": 0.7333984375}], "temperature": 1.0}, {"id": 93, "seek": 259078, "start": 2562.18, "end": 2590.78, "text": "كـ Blocker أو إشي فالـ الشغل اللي بدك تتكلم عنها ماشي اللي هو موضوع إنه الـ الـ الـ protein hormones الـ receptor اللي لهم على سطح الخلية الـ lipid hormone", "tokens": [4117, 39184, 17500, 260, 34051, 11933, 8592, 1829, 6156, 6027, 39184, 25124, 17082, 1211, 13672, 1829, 47525, 4117, 6055, 2655, 4117, 19528, 18871, 11296, 3714, 33599, 1829, 13672, 1829, 31439, 3714, 2407, 11242, 45367, 36145, 3224, 2423, 39184, 2423, 39184, 2423, 39184, 7944, 22453, 2423, 39184, 32264, 13672, 1829, 5296, 16095, 15844, 8608, 9566, 5016, 33962, 1211, 10632, 2423, 39184, 8280, 327, 24211], "avg_logprob": -0.1904296944849193, "compression_ratio": 1.5126582278481013, "no_speech_prob": 3.921985626220703e-05, "words": [{"start": 2562.18, "end": 2563.28, "word": "كـ", "probability": 0.864501953125}, {"start": 2563.28, "end": 2565.22, "word": " Blocker", "probability": 0.8330078125}, {"start": 2565.22, "end": 2565.44, "word": " أو", "probability": 0.97314453125}, {"start": 2565.44, "end": 2565.88, "word": " إشي", "probability": 0.740234375}, {"start": 2565.88, "end": 2570.58, "word": " فالـ", "probability": 0.6774088541666666}, {"start": 2570.58, "end": 2573.66, "word": " الشغل", "probability": 0.73193359375}, {"start": 2573.66, "end": 2574.04, "word": " اللي", "probability": 0.968505859375}, {"start": 2574.04, "end": 2574.88, "word": " بدك", "probability": 0.831787109375}, {"start": 2574.88, "end": 2575.38, "word": " تتكلم", "probability": 0.994873046875}, {"start": 2575.38, "end": 2576.0, "word": " عنها", "probability": 0.987548828125}, {"start": 2576.0, "end": 2577.44, "word": " ماشي", "probability": 0.8600260416666666}, {"start": 2577.44, "end": 2580.82, "word": " اللي", "probability": 0.981201171875}, {"start": 2580.82, "end": 2581.08, "word": " هو", "probability": 0.9951171875}, {"start": 2581.08, "end": 2581.74, "word": " موضوع", "probability": 0.9471435546875}, {"start": 2581.74, "end": 2582.84, "word": " إنه", "probability": 0.700927734375}, {"start": 2582.84, "end": 2583.54, "word": " الـ", "probability": 0.96484375}, {"start": 2583.54, "end": 2584.22, "word": " الـ", "probability": 0.804931640625}, {"start": 2584.22, "end": 2584.84, "word": " الـ", "probability": 0.6832275390625}, {"start": 2584.84, "end": 2585.06, "word": " protein", "probability": 0.294677734375}, {"start": 2585.06, "end": 2585.94, "word": " hormones", "probability": 0.74560546875}, {"start": 2585.94, "end": 2586.8, "word": " الـ", "probability": 0.88232421875}, {"start": 2586.8, "end": 2587.18, "word": " receptor", "probability": 0.429931640625}, {"start": 2587.18, "end": 2587.52, "word": " اللي", "probability": 0.69970703125}, {"start": 2587.52, "end": 2587.8, "word": " لهم", "probability": 0.801025390625}, {"start": 2587.8, "end": 2588.14, "word": " على", "probability": 0.91259765625}, {"start": 2588.14, "end": 2588.5, "word": " سطح", "probability": 0.98876953125}, {"start": 2588.5, "end": 2589.08, "word": " الخلية", "probability": 0.9671223958333334}, {"start": 2589.08, "end": 2590.1, "word": " الـ", "probability": 0.849609375}, {"start": 2590.1, "end": 2590.4, "word": " lipid", "probability": 0.819580078125}, {"start": 2590.4, "end": 2590.78, "word": " hormone", "probability": 0.86962890625}], "temperature": 1.0}, {"id": 94, "seek": 260694, "start": 2591.27, "end": 2606.95, "text": "اللي هم الـ Steroids، فيه Glucocorticoids، Mineralocorticoids، Sex Hormones، الأشياء اللي زي هيكي الـ Receptor تبعهم Intracytoplasmic فهنا يعني أنا أظن السؤال، الـ trick اللي فيه", "tokens": [6027, 20292, 8032, 2304, 2423, 39184, 745, 2032, 3742, 12399, 8978, 3224, 5209, 1311, 905, 477, 2789, 3742, 12399, 2829, 2790, 905, 477, 2789, 3742, 12399, 29037, 389, 687, 2213, 12399, 16247, 8592, 1829, 16606, 13672, 1829, 30767, 1829, 39896, 4117, 1829, 2423, 39184, 1300, 1336, 284, 6055, 3555, 3615, 16095, 5681, 12080, 4328, 404, 7743, 13195, 6156, 3224, 8315, 37495, 22653, 41850, 5551, 19913, 1863, 21136, 33604, 6027, 12399, 2423, 39184, 4282, 13672, 1829, 8978, 3224], "avg_logprob": -0.22796474053309515, "compression_ratio": 1.4204545454545454, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 2591.27, "end": 2591.59, "word": "اللي", "probability": 0.729248046875}, {"start": 2591.59, "end": 2592.41, "word": " هم", "probability": 0.82958984375}, {"start": 2592.41, "end": 2592.61, "word": " الـ", "probability": 0.782470703125}, {"start": 2592.61, "end": 2594.19, "word": " Steroids،", "probability": 0.586578369140625}, {"start": 2594.19, "end": 2594.61, "word": " فيه", "probability": 0.760009765625}, {"start": 2594.61, "end": 2595.99, "word": " Glucocorticoids،", "probability": 0.8547014508928571}, {"start": 2595.99, "end": 2597.31, "word": " Mineralocorticoids،", "probability": 0.8935546875}, {"start": 2597.31, "end": 2597.55, "word": " Sex", "probability": 0.677734375}, {"start": 2597.55, "end": 2598.75, "word": " Hormones،", "probability": 0.7763671875}, {"start": 2598.75, "end": 2599.17, "word": " الأشياء", "probability": 0.93994140625}, {"start": 2599.17, "end": 2599.29, "word": " اللي", "probability": 0.96044921875}, {"start": 2599.29, "end": 2599.53, "word": " زي", "probability": 0.9892578125}, {"start": 2599.53, "end": 2600.05, "word": " هيكي", "probability": 0.8557942708333334}, {"start": 2600.05, "end": 2600.73, "word": " الـ", "probability": 0.811279296875}, {"start": 2600.73, "end": 2601.27, "word": " Receptor", "probability": 0.7696126302083334}, {"start": 2601.27, "end": 2601.83, "word": " تبعهم", "probability": 0.935791015625}, {"start": 2601.83, "end": 2603.17, "word": " Intracytoplasmic", "probability": 0.6639811197916666}, {"start": 2603.17, "end": 2604.15, "word": " فهنا", "probability": 0.7390950520833334}, {"start": 2604.15, "end": 2604.59, "word": " يعني", "probability": 0.966796875}, {"start": 2604.59, "end": 2604.89, "word": " أنا", "probability": 0.626953125}, {"start": 2604.89, "end": 2605.27, "word": " أظن", "probability": 0.93310546875}, {"start": 2605.27, "end": 2605.93, "word": " السؤال،", "probability": 0.84954833984375}, {"start": 2605.93, "end": 2606.05, "word": " الـ", "probability": 0.80322265625}, {"start": 2606.05, "end": 2606.29, "word": " trick", "probability": 0.38671875}, {"start": 2606.29, "end": 2606.57, "word": " اللي", "probability": 0.968994140625}, {"start": 2606.57, "end": 2606.95, "word": " فيه", "probability": 0.9912109375}], "temperature": 1.0}, {"id": 95, "seek": 262533, "start": 2607.39, "end": 2625.33, "text": "إن هدولة كلهم بالأخير بروتينات الـ glucagon والإنسلين والإنسلينات والبروتيرويد والبروجسترول والوحيد الـ intraceptive platelet مني فاهم أنا يعني أكيد جابتهم صحيحة ماشي", "tokens": [28814, 1863, 8032, 3215, 12610, 3660, 28242, 16095, 20666, 10721, 9778, 13546, 4724, 32887, 31371, 8315, 2655, 2423, 39184, 1563, 32072, 10660, 16070, 28814, 1863, 3794, 20292, 1863, 16070, 28814, 1863, 3794, 20292, 8315, 2655, 16070, 26890, 35473, 13546, 2407, 25708, 16070, 26890, 29245, 14851, 2288, 12610, 16070, 2407, 5016, 25708, 2423, 39184, 560, 12080, 5250, 488, 3403, 15966, 9154, 1829, 6156, 995, 16095, 41850, 37495, 22653, 5551, 4117, 25708, 10874, 16758, 2655, 16095, 20328, 5016, 1829, 5016, 3660, 3714, 33599, 1829], "avg_logprob": -0.3800828442516097, "compression_ratio": 1.6022727272727273, "no_speech_prob": 2.0265579223632812e-06, "words": [{"start": 2607.39, "end": 2607.71, "word": "إن", "probability": 0.765869140625}, {"start": 2607.71, "end": 2608.17, "word": " هدولة", "probability": 0.8212890625}, {"start": 2608.17, "end": 2608.69, "word": " كلهم", "probability": 0.897216796875}, {"start": 2608.69, "end": 2609.39, "word": " بالأخير", "probability": 0.8306884765625}, {"start": 2609.39, "end": 2610.91, "word": " بروتينات", "probability": 0.609375}, {"start": 2610.91, "end": 2611.23, "word": " الـ", "probability": 0.5478515625}, {"start": 2611.23, "end": 2611.89, "word": " glucagon", "probability": 0.7157389322916666}, {"start": 2611.89, "end": 2612.81, "word": " والإنسلين", "probability": 0.7075398763020834}, {"start": 2612.81, "end": 2613.41, "word": " والإنسلينات", "probability": 0.7676130022321429}, {"start": 2613.41, "end": 2615.91, "word": " والبروتيرويد", "probability": 0.573822021484375}, {"start": 2615.91, "end": 2617.09, "word": " والبروجسترول", "probability": 0.828857421875}, {"start": 2617.09, "end": 2618.01, "word": " والوحيد", "probability": 0.91162109375}, {"start": 2618.01, "end": 2618.17, "word": " الـ", "probability": 0.61474609375}, {"start": 2618.17, "end": 2618.75, "word": " intraceptive", "probability": 0.34771728515625}, {"start": 2618.75, "end": 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replication proteins، ماشي، سؤال صعب ويعني بتكلم عن مواضيع عميقة كتير ويعني", "tokens": [3555, 3794, 34105, 4724, 39648, 4117, 8272, 12, 65, 9245, 15577, 4090, 35288, 6771, 12399, 745, 2032, 3742, 34102, 293, 32332, 24211, 34102, 11, 4046, 12, 30926, 84, 638, 34102, 11, 17163, 413, 12399, 8272, 35288, 420, 39911, 15577, 12399, 3714, 33599, 1829, 12399, 8608, 33604, 6027, 20328, 3615, 3555, 4032, 40228, 22653, 39894, 4117, 19528, 18871, 3714, 2407, 46958, 40228, 6225, 2304, 1829, 28671, 9122, 2655, 13546, 4032, 40228, 22653], "avg_logprob": -0.2775607539547814, "compression_ratio": 1.385321100917431, "no_speech_prob": 0.0, "words": [{"start": 2625.98, "end": 2627.3, "word": "بس", "probability": 0.851318359375}, {"start": 2627.3, "end": 2627.94, "word": " هنا", "probability": 0.73486328125}, {"start": 2627.94, "end": 2628.4, "word": " بقولك", "probability": 0.8326822916666666}, {"start": 2628.4, "end": 2628.68, "word": " DNA", "probability": 0.51416015625}, {"start": 2628.68, "end": 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"probability": 0.9949544270833334}, {"start": 2647.14, "end": 2648.58, "word": " ويعني", "probability": 0.8321940104166666}, {"start": 2648.58, "end": 2650.96, "word": " بتكلم", "probability": 0.8468424479166666}, {"start": 2650.96, "end": 2651.2, "word": " عن", "probability": 0.96923828125}, {"start": 2651.2, "end": 2651.6, "word": " مواضيع", "probability": 0.955810546875}, {"start": 2651.6, "end": 2652.12, "word": " عميقة", "probability": 0.98681640625}, {"start": 2652.12, "end": 2652.58, "word": " كتير", "probability": 0.8792317708333334}, {"start": 2652.58, "end": 2654.34, "word": " ويعني", "probability": 0.85888671875}], "temperature": 1.0}, {"id": 97, "seek": 268086, "start": 2655.68, "end": 2680.86, "text": "بدو الواحد على الأقل يعني أنا لو طلعت على السؤال ما كنت راح عارف أتجاوبه كنت راح أقول يمكن الـhigh البروجيسترون على أساس هو من نوعية مختلفة يعني استم السؤال الواضح في أشياء كتير وبعدين بيجي بالأخير يقولك أن هذا receptor لهرمون أنوه هرمون هذا والله ما بعرفها ماكنت عارفها من 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يقول لك «طب شو احتمالية ان الطفل اللي بعده يكون نفس الاشي؟» بتقول «لأن الأم بدل ما هي النسبة واحد في كل أربعين ألف في الشكل الطبيعي، بما أن أنا عرفت أن الأم هي الـCarrier وكانت هي اللي حامل الـGene، فإذا احتمالية أن هي تنقل نص", "tokens": [40228, 22653, 1975, 33753, 2304, 6027, 10632, 12174, 20292, 37977, 12399, 4724, 3794, 23758, 8717, 9381, 1829, 3555, 16095, 12399, 3714, 33599, 1829, 6156, 6027, 148, 48506, 13672, 1829, 5296, 15042, 7251, 39648, 5296, 4117, 4657, 9566, 3555, 13412, 2407, 1975, 33753, 2304, 6027, 10632, 16472, 41950, 5172, 1211, 13672, 1829, 39182, 3224, 7251, 30544, 8717, 36178, 2423, 33599, 1829, 22807, 5933, 39894, 39648, 4657, 1211, 33456, 16247, 2304, 47525, 1211, 19446, 39896, 28239, 35457, 3660, 36764, 24401, 8978, 28242, 5551, 25513, 3615, 9957, 5551, 46538, 8978, 25124, 28820, 41950, 21292, 3615, 1829, 12399, 4724, 15042, 14739, 41850, 6225, 28480, 2655, 14739, 16247, 2304, 39896, 2423, 39184, 24437, 7326, 4032, 41361, 2655, 39896, 13672, 1829, 11331, 10943, 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{"start": 3797.45, "end": 3797.83, "word": " to", "probability": 0.7392578125}, {"start": 3797.83, "end": 3798.03, "word": " the", "probability": 0.67822265625}, {"start": 3798.03, "end": 3798.49, "word": " Protein", "probability": 0.87646484375}, {"start": 3798.49, "end": 3798.95, "word": " Synthesis", "probability": 0.870849609375}, {"start": 3798.95, "end": 3799.57, "word": " Complex", "probability": 0.9716796875}], "temperature": 1.0}, {"id": 139, "seek": 382836, "start": 3800.42, "end": 3828.36, "text": "ماشي اللي هم يعني charged هنا بمعنى أنه الـ Transferral RNA عليه الـ amino acid اللي بده يشبك على الـ polypeptide chain الـ elongation factors اللي هم facilitate الـ Transferral RNA binding to the transcription steps in protein synthesis يعني اللي هم بضيفاً الـ Transcription proteins pre-RNA", "tokens": [2304, 33599, 1829, 13672, 1829, 8032, 2304, 37495, 22653, 11109, 34105, 4724, 2304, 3615, 1863, 7578, 14739, 3224, 2423, 39184, 6531, 612, 2155, 22484, 47356, 2423, 39184, 24674, 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"end": 4161.42, "word": " عشان", "probability": 0.8982747395833334}, {"start": 4161.42, "end": 4162.18, "word": " يشوفوا", "probability": 0.986572265625}, {"start": 4162.18, "end": 4162.64, "word": " من", "probability": 0.96240234375}, {"start": 4162.64, "end": 4162.94, "word": " أين", "probability": 0.779541015625}, {"start": 4162.94, "end": 4163.38, "word": " أخذ", "probability": 0.8850911458333334}, {"start": 4163.38, "end": 4163.8, "word": " المرض", "probability": 0.981689453125}, {"start": 4163.8, "end": 4164.96, "word": " هذا،", "probability": 0.8642578125}, {"start": 4164.96, "end": 4165.44, "word": " تمام؟", "probability": 0.9143880208333334}], "temperature": 1.0}, {"id": 153, "seek": 419285, "start": 4167.4, "end": 4192.86, "text": "ماشي الحال؟ أمامك الله الـ DNA samples from the child mother and father were obtained and the DNA is fragmented with restriction enzyme the fragments are then stored sorted يعني عملنا Electrophoresis by size using southern blot technique ال southern blot هذا نوعية بعد ما تعمل انت Electrophoresis ما بتقدر تشوفهم", "tokens": [2304, 33599, 1829, 21542, 6027, 22807, 5551, 2304, 10943, 4117, 21984, 2423, 39184, 8272, 10938, 490, 264, 1440, 2895, 293, 3086, 645, 14879, 293, 264, 8272, 307, 9241, 14684, 365, 29529, 24521, 264, 29197, 366, 550, 12187, 25462, 37495, 22653, 6225, 42213, 8315, 12575, 11741, 2706, 271, 538, 2744, 1228, 13456, 888, 310, 6532, 2423, 13456, 888, 310, 23758, 8717, 45367, 10632, 39182, 19446, 6055, 25957, 1211, 16472, 2655, 12575, 11741, 2706, 271, 19446, 39894, 28543, 2288, 6055, 8592, 38688, 16095], "avg_logprob": -0.3109756010334666, "compression_ratio": 1.4881889763779528, "no_speech_prob": 0.0, "words": [{"start": 4167.4, "end": 4167.82, "word": "ماشي", "probability": 0.7569986979166666}, {"start": 4167.82, "end": 4168.42, "word": " الحال؟", "probability": 0.81982421875}, {"start": 4168.42, "end": 4168.92, "word": " أمامك", "probability": 0.445037841796875}, {"start": 4168.92, "end": 4169.28, "word": " الله", "probability": 0.40283203125}, {"start": 4169.28, "end": 4169.92, "word": " الـ", "probability": 0.5484619140625}, {"start": 4169.92, "end": 4170.52, "word": " DNA", "probability": 0.29638671875}, {"start": 4170.52, "end": 4171.08, "word": " samples", "probability": 0.133544921875}, {"start": 4171.08, "end": 4171.44, "word": " from", "probability": 0.66357421875}, {"start": 4171.44, "end": 4171.64, "word": " the", "probability": 0.8720703125}, {"start": 4171.64, "end": 4171.98, "word": " child", "probability": 0.87890625}, {"start": 4171.98, "end": 4172.34, "word": " mother", "probability": 0.40185546875}, {"start": 4172.34, "end": 4172.82, "word": " and", "probability": 0.87841796875}, {"start": 4172.82, "end": 4173.4, "word": " father", "probability": 0.83837890625}, {"start": 4173.4, "end": 4174.0, "word": " were", "probability": 0.404541015625}, {"start": 4174.0, "end": 4174.54, "word": " obtained", "probability": 0.94482421875}, {"start": 4174.54, "end": 4174.76, "word": " and", "probability": 0.65185546875}, {"start": 4174.76, "end": 4174.9, "word": " the", "probability": 0.791015625}, {"start": 4174.9, "end": 4175.28, "word": " DNA", "probability": 0.93359375}, {"start": 4175.28, "end": 4175.72, "word": " is", "probability": 0.91064453125}, {"start": 4175.72, "end": 4176.46, "word": " fragmented", "probability": 0.9072265625}, {"start": 4176.46, "end": 4176.84, "word": " with", "probability": 0.8984375}, {"start": 4176.84, "end": 4177.3, "word": " restriction", "probability": 0.1932373046875}, {"start": 4177.3, "end": 4177.98, "word": " enzyme", "probability": 0.81396484375}, {"start": 4177.98, "end": 4178.76, "word": " the", "probability": 0.395751953125}, {"start": 4178.76, "end": 4179.24, "word": " fragments", "probability": 0.89697265625}, {"start": 4179.24, "end": 4179.58, "word": " are", "probability": 0.93408203125}, {"start": 4179.58, "end": 4179.86, "word": " then", "probability": 0.720703125}, {"start": 4179.86, "end": 4180.44, "word": " 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4187.44, "word": " southern", "probability": 0.331787109375}, {"start": 4187.44, "end": 4188.56, "word": " blot", "probability": 0.92626953125}, {"start": 4188.56, "end": 4188.86, "word": " هذا", "probability": 0.7646484375}, {"start": 4188.86, "end": 4189.54, "word": " نوعية", "probability": 0.9274088541666666}, {"start": 4189.54, "end": 4189.94, "word": " بعد", "probability": 0.9345703125}, {"start": 4189.94, "end": 4190.08, "word": " ما", "probability": 0.77734375}, {"start": 4190.08, "end": 4190.44, "word": " تعمل", "probability": 0.98974609375}, {"start": 4190.44, "end": 4190.68, "word": " انت", "probability": 0.733642578125}, {"start": 4190.68, "end": 4191.74, "word": " Electrophoresis", "probability": 0.938720703125}, {"start": 4191.74, "end": 4191.92, "word": " ما", "probability": 0.77197265625}, {"start": 4191.92, "end": 4192.28, "word": " بتقدر", "probability": 0.83935546875}, {"start": 4192.28, "end": 4192.86, "word": " تشوفهم", "probability": 0.9927978515625}], "temperature": 1.0}, {"id": 154, "seek": 421992, "start": 4193.5, "end": 4219.92, "text": "فبتجيب بعد ما تعمل الـ Electrophoresis بتحط عليها طبقة ثانية وبتسمحله يصير Blocking يعني طبق وبتشوف أين أجى المكان تبعه فـ Labeling is done using a probe that binds to a specific DNA sequence close to the centromere of chromosome 21 The Repelif Analysis", "tokens": [5172, 3555, 2655, 7435, 1829, 3555, 39182, 19446, 6055, 25957, 1211, 2423, 39184, 12575, 11741, 2706, 271, 39894, 5016, 9566, 25894, 11296, 23032, 3555, 28671, 38637, 7649, 10632, 46599, 2655, 38251, 5016, 43761, 7251, 9381, 13546, 17500, 278, 37495, 22653, 23032, 3555, 4587, 46599, 2655, 8592, 38688, 5551, 9957, 5551, 7435, 7578, 9673, 41361, 6055, 3555, 3615, 3224, 6156, 39184, 10137, 11031, 307, 1096, 1228, 257, 22715, 300, 41515, 281, 257, 2685, 8272, 8310, 1998, 281, 264, 1489, 4397, 323, 295, 42896, 5080, 440, 3696, 338, 351, 38172], "avg_logprob": -0.2686095559195186, "compression_ratio": 1.3333333333333333, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 4193.5, "end": 4194.64, "word": "فبتجيب", "probability": 0.6923828125}, {"start": 4194.64, "end": 4195.12, "word": " بعد", "probability": 0.76611328125}, {"start": 4195.12, "end": 4195.26, "word": " ما", "probability": 0.85791015625}, {"start": 4195.26, "end": 4195.62, "word": " تعمل", "probability": 0.9869791666666666}, {"start": 4195.62, "end": 4195.76, "word": " الـ", "probability": 0.918212890625}, {"start": 4195.76, "end": 4196.64, "word": " Electrophoresis", "probability": 0.892822265625}, {"start": 4196.64, "end": 4197.12, "word": " بتحط", "probability": 0.7133382161458334}, {"start": 4197.12, "end": 4197.7, "word": " عليها", "probability": 0.98876953125}, {"start": 4197.7, "end": 4198.8, "word": " طبقة", "probability": 0.9611002604166666}, {"start": 4198.8, "end": 4199.32, "word": " ثانية", "probability": 0.9873046875}, {"start": 4199.32, "end": 4200.28, "word": " وبتسمحله", "probability": 0.8072265625}, {"start": 4200.28, "end": 4201.06, "word": " يصير", "probability": 0.7150065104166666}, {"start": 4201.06, "end": 4201.74, "word": " Blocking", "probability": 0.491058349609375}, {"start": 4201.74, "end": 4202.04, "word": " يعني", "probability": 0.8056640625}, {"start": 4202.04, "end": 4202.76, "word": " طبق", "probability": 0.76708984375}, {"start": 4202.76, "end": 4204.32, "word": " وبتشوف", "probability": 0.904541015625}, {"start": 4204.32, "end": 4204.68, "word": " أين", "probability": 0.86376953125}, {"start": 4204.68, "end": 4205.06, "word": " أجى", "probability": 0.7080078125}, {"start": 4205.06, "end": 4205.48, "word": " المكان", "probability": 0.988525390625}, {"start": 4205.48, "end": 4206.2, "word": " تبعه", "probability": 0.8670654296875}, {"start": 4206.2, "end": 4207.38, "word": " فـ", "probability": 0.53173828125}, {"start": 4207.38, "end": 4208.38, "word": " Labeling", "probability": 0.579833984375}, {"start": 4208.38, "end": 4208.98, "word": " is", "probability": 0.91796875}, {"start": 4208.98, "end": 4209.38, "word": " done", "probability": 0.935546875}, {"start": 4209.38, "end": 4210.04, "word": " using", "probability": 0.9052734375}, {"start": 4210.04, "end": 4210.5, "word": " a", "probability": 0.978515625}, {"start": 4210.5, "end": 4210.88, "word": " probe", "probability": 0.97314453125}, {"start": 4210.88, "end": 4211.2, "word": " that", "probability": 0.8798828125}, {"start": 4211.2, "end": 4211.66, "word": " binds", "probability": 0.8916015625}, {"start": 4211.66, "end": 4211.84, "word": " to", "probability": 0.7822265625}, {"start": 4211.84, "end": 4211.86, "word": " a", "probability": 0.54736328125}, {"start": 4211.86, "end": 4212.24, "word": " specific", "probability": 0.89794921875}, {"start": 4212.24, "end": 4212.7, "word": " DNA", "probability": 0.93798828125}, {"start": 4212.7, "end": 4213.32, "word": " sequence", "probability": 0.9658203125}, {"start": 4213.32, "end": 4213.68, "word": " close", "probability": 0.82861328125}, {"start": 4213.68, "end": 4213.88, "word": " to", "probability": 0.982421875}, {"start": 4213.88, "end": 4214.08, "word": " the", "probability": 0.8994140625}, {"start": 4214.08, "end": 4214.8, "word": " centromere", "probability": 0.9405924479166666}, {"start": 4214.8, "end": 4215.42, "word": " of", "probability": 0.97265625}, {"start": 4215.42, "end": 4215.92, "word": " chromosome", "probability": 0.90380859375}, {"start": 4215.92, "end": 4216.7, "word": " 21", "probability": 0.94580078125}, {"start": 4216.7, "end": 4218.3, "word": " The", "probability": 0.52978515625}, {"start": 4218.3, "end": 4219.14, "word": " Repelif", "probability": 0.296875}, {"start": 4219.14, "end": 4219.92, "word": " Analysis", "probability": 0.66552734375}], "temperature": 1.0}, {"id": 155, "seek": 424977, "start": 4221.31, "end": 4249.77, "text": "of the child mother is shown below فهيكي شكله الـ mother هيكي ال father هيكي وال child هيكي هذولة يعني مكان وين الـ centromere تبع chromosome 21 موجود في كل واحد منهم ماشي ال mother القناها الثنتين هذولة ال father القناها بالثنتين هذولة ال child عنده هذولة الثلاثة", "tokens": [2670, 264, 1440, 2895, 307, 4898, 2507, 6156, 3224, 1829, 4117, 1829, 13412, 28820, 3224, 2423, 39184, 2895, 39896, 4117, 1829, 2423, 3086, 39896, 4117, 1829, 16070, 1440, 39896, 4117, 1829, 8032, 8848, 12610, 3660, 37495, 22653, 3714, 41361, 4032, 9957, 2423, 39184, 1489, 4397, 323, 6055, 3555, 3615, 42896, 5080, 3714, 29245, 23328, 8978, 28242, 36764, 24401, 9154, 16095, 3714, 33599, 1829, 2423, 2895, 25062, 8315, 11296, 6024, 104, 29399, 9957, 8032, 8848, 12610, 3660, 2423, 3086, 25062, 8315, 11296, 20666, 12984, 29399, 9957, 8032, 8848, 12610, 3660, 2423, 1440, 43242, 3224, 8032, 8848, 12610, 3660, 6024, 104, 1211, 5718, 104, 3660], "avg_logprob": -0.18164063144761783, "compression_ratio": 1.9178743961352658, "no_speech_prob": 1.6689300537109375e-05, "words": [{"start": 4221.31, "end": 4221.55, "word": "of", "probability": 0.044097900390625}, {"start": 4221.55, "end": 4221.73, "word": " the", "probability": 0.85546875}, {"start": 4221.73, "end": 4222.03, "word": " child", "probability": 0.876953125}, {"start": 4222.03, "end": 4222.45, "word": " mother", "probability": 0.80029296875}, {"start": 4222.45, "end": 4222.89, "word": " is", "probability": 0.91845703125}, {"start": 4222.89, "end": 4223.19, "word": " shown", "probability": 0.87353515625}, {"start": 4223.19, "end": 4223.65, "word": " below", "probability": 0.91162109375}, {"start": 4223.65, "end": 4224.57, "word": " فهيكي", "probability": 0.76259765625}, {"start": 4224.57, "end": 4225.03, "word": " شكله", "probability": 0.9718424479166666}, {"start": 4225.03, "end": 4225.57, "word": " الـ", "probability": 0.56396484375}, {"start": 4225.57, "end": 4225.79, "word": " mother", "probability": 0.591796875}, {"start": 4225.79, "end": 4226.33, "word": " هيكي", "probability": 0.9884440104166666}, {"start": 4226.33, "end": 4226.65, "word": " ال", "probability": 0.63427734375}, {"start": 4226.65, "end": 4226.97, "word": " father", "probability": 0.51806640625}, {"start": 4226.97, "end": 4227.59, "word": " هيكي", "probability": 0.9951171875}, {"start": 4227.59, "end": 4228.21, "word": " وال", "probability": 0.705078125}, {"start": 4228.21, "end": 4228.57, "word": " child", "probability": 0.5546875}, {"start": 4228.57, "end": 4229.37, "word": " هيكي", "probability": 0.9920247395833334}, {"start": 4229.37, "end": 4230.21, "word": " هذولة", "probability": 0.70458984375}, {"start": 4230.21, "end": 4231.07, "word": " يعني", "probability": 0.95458984375}, {"start": 4231.07, "end": 4232.09, "word": " مكان", "probability": 0.97900390625}, {"start": 4232.09, "end": 4233.17, "word": " وين", "probability": 0.925048828125}, {"start": 4233.17, "end": 4233.49, "word": " الـ", "probability": 0.612548828125}, {"start": 4233.49, "end": 4234.11, "word": " centromere", "probability": 0.818359375}, {"start": 4234.11, "end": 4234.63, "word": " تبع", "probability": 0.86474609375}, {"start": 4234.63, "end": 4235.17, "word": " chromosome", "probability": 0.372802734375}, {"start": 4235.17, "end": 4235.87, "word": " 21", "probability": 0.8623046875}, {"start": 4235.87, "end": 4236.59, "word": " موجود", "probability": 0.9724934895833334}, {"start": 4236.59, "end": 4236.83, "word": " في", "probability": 0.9638671875}, {"start": 4236.83, "end": 4237.15, "word": " كل", "probability": 0.97607421875}, {"start": 4237.15, "end": 4237.63, "word": " واحد", "probability": 0.996337890625}, {"start": 4237.63, "end": 4238.71, "word": " منهم", "probability": 0.96435546875}, {"start": 4238.71, "end": 4240.09, "word": " ماشي", "probability": 0.849609375}, {"start": 4240.09, "end": 4241.03, "word": " ال", "probability": 0.955078125}, {"start": 4241.03, "end": 4241.97, "word": " mother", "probability": 0.64453125}, {"start": 4241.97, "end": 4242.77, "word": " القناها", "probability": 0.77880859375}, {"start": 4242.77, "end": 4243.27, "word": " الثنتين", "probability": 0.8433837890625}, {"start": 4243.27, "end": 4243.85, "word": 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هذا الطفل؟ المشكلة عند أبوه ولا أمه يا معتز؟ عنده Trisomy 21، يعني ماياخد two copies من واحد وماياخد copy واحد من شخص تاني، من من من، تتوقع من من المشكلة؟ من الأم أخد two copies من الأم أخدتنتين، تفهم علي؟", "tokens": [2304, 33599, 1829, 12399, 1975, 15730, 13412, 2407, 13672, 1829, 20328, 9640, 43242, 23758, 41950, 5172, 1211, 22807, 9673, 8592, 28820, 3660, 43242, 5551, 3555, 2407, 3224, 49429, 5551, 2304, 3224, 35186, 3714, 34268, 11622, 22807, 43242, 3224, 1765, 271, 8488, 5080, 12399, 37495, 22653, 19446, 1829, 47283, 3215, 732, 14341, 9154, 36764, 24401, 4032, 15042, 1829, 47283, 3215, 5055, 36764, 24401, 9154, 13412, 9778, 9381, 6055, 7649, 1829, 12399, 9154, 9154, 9154, 12399, 6055, 2655, 30543, 3615, 9154, 9154, 9673, 8592, 28820, 3660, 22807, 9154, 16247, 2304, 5551, 9778, 3215, 732, 14341, 9154, 16247, 2304, 5551, 9778, 3215, 2655, 29399, 9957, 12399, 6055, 5172, 16095, 25894, 22807], "avg_logprob": -0.23423165848495764, "compression_ratio": 1.8421052631578947, 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"word": " هيك", "probability": 0.6873779296875}, {"start": 4420.97, "end": 4421.47, "word": " وهيك", "probability": 0.83154296875}, {"start": 4421.47, "end": 4423.09, "word": " ماشي،", "probability": 0.6790771484375}, {"start": 4423.09, "end": 4423.63, "word": " هذولة", "probability": 0.687713623046875}, {"start": 4423.63, "end": 4423.87, "word": " الـ", "probability": 0.970458984375}, {"start": 4423.87, "end": 4424.07, "word": " two", "probability": 0.309814453125}, {"start": 4424.07, "end": 4424.63, "word": " copies", "probability": 0.9873046875}, {"start": 4424.63, "end": 4425.11, "word": " from", "probability": 0.8056640625}, {"start": 4425.11, "end": 4425.31, "word": " the", "probability": 0.9326171875}, {"start": 4425.31, "end": 4425.57, "word": " same", "probability": 0.91259765625}, {"start": 4425.57, "end": 4426.31, "word": " chromosome", "probability": 0.94921875}, {"start": 4426.31, "end": 4428.47, "word": " بنقسموا", "probability": 0.8685302734375}, {"start": 4428.47, "end": 4429.09, "word": " بحيث", "probability": 0.9122314453125}, {"start": 4429.09, "end": 4429.35, "word": " يكون", "probability": 0.991455078125}, {"start": 4429.35, "end": 4429.57, "word": " one", "probability": 0.90087890625}, {"start": 4429.57, "end": 4430.09, "word": " chromosome", "probability": 0.97021484375}, {"start": 4430.09, "end": 4430.37, "word": " هنا", "probability": 0.61181640625}, {"start": 4430.37, "end": 4430.49, "word": " و", "probability": 0.91015625}, {"start": 4430.49, "end": 4430.65, "word": " one", "probability": 0.68505859375}, {"start": 4430.65, "end": 4431.07, "word": " chromosome", "probability": 0.98095703125}, {"start": 4431.07, "end": 4431.35, "word": " هنا", "probability": 0.95703125}, {"start": 4431.35, "end": 4432.43, "word": " وبعدين", "probability": 0.8494466145833334}, {"start": 4432.43, "end": 4433.27, "word": " بنفصل", "probability": 0.9334309895833334}, {"start": 4433.27, "end": 4433.83, "word": " بهذا", "probability": 0.96875}, {"start": 4433.83, "end": 4434.23, "word": " الشكل", "probability": 0.993896484375}], "temperature": 1.0}, {"id": 163, "seek": 444706, "start": 4435.0, "end": 4447.06, "text": "إذا كان الـ Non-Disjunction ممكن يكون في الـ Meiosis I وممكن يكون في الـ Meiosis II وهنا صار Non-Disjunction وهنا الـ Step الأولى Non-Disjunction", "tokens": [28814, 15730, 25961, 2423, 39184, 8774, 12, 38742, 10010, 882, 3714, 43020, 7251, 30544, 8978, 2423, 39184, 1923, 48783, 286, 4032, 2304, 43020, 7251, 30544, 8978, 2423, 39184, 1923, 48783, 6351, 37037, 8315, 20328, 9640, 8774, 12, 38742, 10010, 882, 37037, 8315, 2423, 39184, 5470, 16247, 12610, 7578, 8774, 12, 38742, 10010, 882], "avg_logprob": -0.3990161970809654, "compression_ratio": 1.7946428571428572, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 4435.0, "end": 4435.44, "word": "إذا", "probability": 0.7880859375}, {"start": 4435.44, "end": 4435.72, "word": " كان", "probability": 0.6025390625}, {"start": 4435.72, "end": 4435.72, "word": " الـ", 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حكيناها shows that both parents demonstrate two bands each parental band represents a homologous chromosome 21 this child has three bands", "tokens": [9566, 1829, 3555, 46599, 22488, 9957, 2107, 12, 13731, 10010, 882, 307, 257, 7763, 295, 42896, 15494, 281, 4994, 341, 727, 312, 7763, 295, 23032, 3555, 19446, 11331, 4117, 1829, 8315, 11296, 3110, 300, 1293, 3152, 11698, 732, 13543, 1184, 41113, 4116, 8855, 257, 3655, 1132, 563, 42896, 5080, 341, 1440, 575, 1045, 13543], "avg_logprob": -0.3178977142680775, "compression_ratio": 1.4285714285714286, "no_speech_prob": 0.0, "words": [{"start": 4481.37, "end": 4481.79, "word": "طيب", "probability": 0.7273356119791666}, {"start": 4481.79, "end": 4482.55, "word": " وبعدين", "probability": 0.7180989583333334}, {"start": 4482.55, "end": 4483.59, "word": " non", "probability": 0.11181640625}, {"start": 4483.59, "end": 4484.31, "word": "-disjunction", "probability": 0.84613037109375}, {"start": 4484.31, "end": 4484.51, "word": " is", "probability": 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0.557470703125}, {"start": 4581.17, "end": 4581.89, "word": " pH،", "probability": 0.56982421875}, {"start": 4581.89, "end": 4581.99, "word": " وهي", "probability": 0.3773193359375}, {"start": 4581.99, "end": 4582.51, "word": " الميزات", "probability": 0.416290283203125}, {"start": 4582.51, "end": 4584.43, "word": " المظهرة", "probability": 0.5490234375}, {"start": 4584.43, "end": 4584.77, "word": " هنا", "probability": 0.93310546875}], "temperature": 1.0}, {"id": 169, "seek": 462202, "start": 4596.52, "end": 4622.02, "text": "هه؟ الـ Hemoglobin S يعني Sickle Cell Disease الأنيميا والـ Jaundice ماشي ماعرفش ليش الـ swellings of the hands and feet السبب فالـ بالنسبة له في الحالة هذه بكون شو اسمه؟", "tokens": [3224, 3224, 22807, 2423, 39184, 18568, 45841, 13496, 318, 37495, 22653, 43471, 306, 28859, 35360, 16247, 22653, 2304, 25528, 16070, 39184, 3530, 997, 573, 3714, 33599, 1829, 19446, 3615, 28480, 8592, 32239, 8592, 2423, 39184, 34251, 1109, 295, 264, 2377, 293, 3521, 21136, 3555, 3555, 6156, 6027, 39184, 20666, 1863, 35457, 3660, 46740, 8978, 21542, 6027, 3660, 29538, 4724, 30544, 13412, 2407, 24525, 2304, 3224, 22807], "avg_logprob": -0.33885261905727104, "compression_ratio": 1.3626373626373627, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 4596.52, "end": 4597.6, "word": "هه؟", "probability": 0.2861124674479167}, {"start": 4597.6, "end": 4598.68, "word": " الـ", "probability": 0.517242431640625}, {"start": 4598.68, "end": 4599.22, "word": " Hemoglobin", "probability": 0.81298828125}, {"start": 4599.22, "end": 4599.7, "word": " S", "probability": 0.5634765625}, {"start": 4599.7, "end": 4600.94, "word": " يعني", "probability": 0.6802978515625}, {"start": 4600.94, "end": 4601.42, "word": " Sickle", "probability": 0.6846923828125}, {"start": 4601.42, "end": 4601.6, "word": " Cell", "probability": 0.79833984375}, {"start": 4601.6, "end": 4602.12, "word": " Disease", "probability": 0.9140625}, {"start": 4602.12, "end": 4603.96, "word": " الأنيميا", "probability": 0.69586181640625}, {"start": 4603.96, "end": 4604.66, "word": " والـ", "probability": 0.90283203125}, {"start": 4604.66, "end": 4605.36, "word": " Jaundice", "probability": 0.8006998697916666}, {"start": 4605.36, "end": 4606.68, "word": " ماشي", "probability": 0.7804361979166666}, {"start": 4606.68, "end": 4608.48, "word": " ماعرفش", "probability": 0.74127197265625}, {"start": 4608.48, "end": 4608.74, "word": " ليش", "probability": 0.9619140625}, {"start": 4608.74, "end": 4609.04, "word": " الـ", "probability": 0.89013671875}, {"start": 4609.04, "end": 4609.6, "word": " swellings", "probability": 0.53082275390625}, {"start": 4609.6, "end": 4609.8, "word": " of", "probability": 0.86865234375}, {"start": 4609.8, "end": 4609.98, "word": " the", "probability": 0.80078125}, {"start": 4609.98, "end": 4610.3, "word": " hands", "probability": 0.89892578125}, {"start": 4610.3, "end": 4610.56, "word": " and", "probability": 0.83642578125}, {"start": 4610.56, "end": 4610.96, "word": " feet", "probability": 0.90869140625}, {"start": 4610.96, "end": 4612.3, "word": " السبب", "probability": 0.9786783854166666}, {"start": 4612.3, "end": 4614.26, "word": " فالـ", "probability": 0.6739908854166666}, {"start": 4614.26, "end": 4615.42, "word": " بالنسبة", "probability": 0.9569091796875}, {"start": 4615.42, "end": 4615.72, "word": " له", "probability": 0.669921875}, {"start": 4615.72, "end": 4615.9, "word": " في", "probability": 0.93017578125}, {"start": 4615.9, "end": 4616.34, "word": " الحالة", "probability": 0.9606119791666666}, {"start": 4616.34, "end": 4616.76, "word": " هذه", "probability": 0.96630859375}, {"start": 4616.76, "end": 4620.0, "word": " بكون", "probability": 0.769287109375}, {"start": 4620.0, "end": 4620.88, "word": " شو", "probability": 0.6695556640625}, {"start": 4620.88, "end": 4622.02, "word": " اسمه؟", "probability": 0.9388427734375}], "temperature": 1.0}, {"id": 170, "seek": 465380, "start": 4628.3, "end": 4653.8, "text": "عملوا Hemoglobin Electrophoresis هنا فالـ Hemoglobin A مش موجود هذا لمين؟ للطفل المصاب، صح؟ Blood sample is obtained from the boy and Hemoglobin Electrophoresis is performed at alkaline pH، ماشي الحال، فكل الـ Hemoglobin تبعه", "tokens": [25957, 1211, 14407, 18568, 45841, 13496, 12575, 11741, 2706, 271, 34105, 6156, 6027, 39184, 18568, 45841, 13496, 316, 37893, 3714, 29245, 23328, 23758, 32767, 9957, 22807, 24976, 9566, 5172, 1211, 9673, 9381, 16758, 12399, 20328, 5016, 22807, 17428, 6889, 307, 14879, 490, 264, 3237, 293, 18568, 45841, 13496, 12575, 11741, 2706, 271, 307, 10332, 412, 44220, 533, 21677, 12399, 3714, 33599, 1829, 21542, 6027, 12399, 6156, 28820, 2423, 39184, 18568, 45841, 13496, 6055, 3555, 3615, 3224], "avg_logprob": -0.25020292362609464, "compression_ratio": 1.4619289340101522, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 4628.3, "end": 4629.54, "word": "عملوا", "probability": 0.5839436848958334}, {"start": 4629.54, "end": 4630.16, "word": " Hemoglobin", "probability": 0.7307535807291666}, {"start": 4630.16, "end": 4631.2, "word": " Electrophoresis", "probability": 0.9547119140625}, {"start": 4631.2, "end": 4631.54, "word": " هنا", "probability": 0.4912109375}, {"start": 4631.54, "end": 4632.88, "word": " فالـ", "probability": 0.7527669270833334}, {"start": 4632.88, "end": 4633.5, "word": " Hemoglobin", "probability": 0.744384765625}, {"start": 4633.5, "end": 4633.86, "word": " A", "probability": 0.7939453125}, {"start": 4633.86, "end": 4634.7, "word": " مش", "probability": 0.26953125}, {"start": 4634.7, "end": 4635.26, "word": " موجود", "probability": 0.9851888020833334}, {"start": 4635.26, "end": 4635.54, "word": " هذا", "probability": 0.494873046875}, {"start": 4635.54, "end": 4636.1, "word": " لمين؟", "probability": 0.72412109375}, {"start": 4636.1, "end": 4637.32, "word": " للطفل", "probability": 0.83984375}, {"start": 4637.32, "end": 4637.98, "word": " المصاب،", "probability": 0.8843994140625}, {"start": 4637.98, "end": 4639.86, "word": " صح؟", "probability": 0.9892578125}, {"start": 4639.86, "end": 4641.24, "word": " Blood", "probability": 0.07232666015625}, {"start": 4641.24, "end": 4641.92, "word": " sample", "probability": 0.72412109375}, {"start": 4641.92, "end": 4642.36, "word": " is", "probability": 0.85302734375}, {"start": 4642.36, "end": 4642.8, "word": " obtained", "probability": 0.91796875}, {"start": 4642.8, "end": 4643.04, "word": " from", "probability": 0.8994140625}, {"start": 4643.04, "end": 4643.26, "word": " the", "probability": 0.82177734375}, {"start": 4643.26, "end": 4643.64, "word": " boy", "probability": 0.90869140625}, {"start": 4643.64, "end": 4644.08, "word": " and", "probability": 0.82470703125}, {"start": 4644.08, "end": 4644.72, "word": " Hemoglobin", "probability": 0.9353841145833334}, {"start": 4644.72, "end": 4645.74, "word": " Electrophoresis", "probability": 0.9737548828125}, {"start": 4645.74, "end": 4645.94, "word": " is", "probability": 0.91259765625}, {"start": 4645.94, "end": 4646.5, "word": " performed", "probability": 0.75390625}, {"start": 4646.5, "end": 4647.26, "word": " at", "probability": 0.78125}, {"start": 4647.26, "end": 4647.86, "word": " alkaline", "probability": 0.97119140625}, {"start": 4647.86, "end": 4649.64, "word": " pH،", "probability": 0.702392578125}, {"start": 4649.64, "end": 4649.9, "word": " ماشي", "probability": 0.7509765625}, {"start": 4649.9, "end": 4651.04, "word": " الحال،", "probability": 0.8876953125}, {"start": 4651.04, "end": 4652.38, "word": " فكل", "probability": 0.7939453125}, {"start": 4652.38, "end": 4652.58, "word": " الـ", "probability": 0.883056640625}, {"start": 4652.58, "end": 4653.16, "word": " Hemoglobin", "probability": 0.89306640625}, {"start": 4653.16, "end": 4653.8, "word": " تبعه", "probability": 0.9073486328125}], "temperature": 1.0}, {"id": 171, "seek": 467862, "start": 4654.82, "end": 4678.62, "text": "ماشي، Hemoglobin S يعني مافيش Hemoglobin A ولا Hemoglobin F اللي بيخفف وكله Hemoglobin S، تمام؟ فالآن السؤال What is the probability that the unborn child will inherit one or more mutant alleles from his parents؟ فشو هذا الـ Disease يا معتز؟", "tokens": [2304, 33599, 1829, 12399, 18568, 45841, 13496, 318, 37495, 22653, 19446, 41185, 8592, 18568, 45841, 13496, 316, 49429, 18568, 45841, 13496, 479, 13672, 1829, 4724, 1829, 9778, 5172, 5172, 4032, 28820, 3224, 18568, 45841, 13496, 318, 12399, 46811, 10943, 22807, 6156, 6027, 148, 48506, 21136, 33604, 6027, 708, 307, 264, 8482, 300, 264, 517, 10324, 1440, 486, 21389, 472, 420, 544, 47198, 439, 6972, 490, 702, 3152, 22807, 6156, 8592, 2407, 23758, 2423, 39184, 35360, 35186, 20449, 2655, 11622, 22807], "avg_logprob": -0.2488425925925926, "compression_ratio": 1.3677130044843049, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 4654.82, "end": 4655.58, "word": "ماشي،", "probability": 0.6812744140625}, {"start": 4655.58, "end": 4656.14, "word": " Hemoglobin", "probability": 0.7515462239583334}, {"start": 4656.14, "end": 4656.52, "word": " S", "probability": 0.7119140625}, {"start": 4656.52, "end": 4657.68, "word": " يعني", "probability": 0.821533203125}, {"start": 4657.68, "end": 4658.16, "word": " مافيش", "probability": 0.4349772135416667}, {"start": 4658.16, "end": 4658.72, "word": " Hemoglobin", "probability": 0.9308268229166666}, {"start": 4658.72, "end": 4659.0, "word": " A", "probability": 0.966796875}, {"start": 4659.0, "end": 4659.28, "word": " ولا", "probability": 0.7861328125}, {"start": 4659.28, "end": 4660.1, "word": " Hemoglobin", "probability": 0.7615559895833334}, {"start": 4660.1, "end": 4660.46, "word": " F", "probability": 0.99462890625}, {"start": 4660.46, "end": 4661.1, "word": " اللي", "probability": 0.896484375}, {"start": 4661.1, "end": 4661.76, "word": " بيخفف", "probability": 0.928125}, {"start": 4661.76, "end": 4662.24, "word": " وكله", "probability": 0.7096354166666666}, {"start": 4662.24, "end": 4662.84, "word": " Hemoglobin", "probability": 0.9651692708333334}, {"start": 4662.84, "end": 4663.56, "word": " S،", "probability": 0.672607421875}, {"start": 4663.56, "end": 4666.06, "word": " تمام؟", "probability": 0.9010416666666666}, {"start": 4666.06, "end": 4666.62, "word": " فالآن", "probability": 0.78607177734375}, {"start": 4666.62, "end": 4667.28, "word": " السؤال", "probability": 0.9920247395833334}, {"start": 4667.28, "end": 4667.9, "word": " What", "probability": 0.242919921875}, {"start": 4667.9, "end": 4668.14, "word": " is", "probability": 0.93408203125}, {"start": 4668.14, "end": 4668.3, "word": " the", "probability": 0.876953125}, {"start": 4668.3, "end": 4668.9, "word": " probability", "probability": 0.95068359375}, {"start": 4668.9, "end": 4669.24, "word": " that", "probability": 0.91552734375}, {"start": 4669.24, "end": 4669.4, "word": " the", "probability": 0.86474609375}, {"start": 4669.4, "end": 4669.88, "word": " unborn", "probability": 0.931396484375}, {"start": 4669.88, "end": 4670.44, "word": " child", "probability": 0.88134765625}, {"start": 4670.44, "end": 4670.88, "word": " will", "probability": 0.87939453125}, {"start": 4670.88, "end": 4671.52, "word": " inherit", "probability": 0.94970703125}, {"start": 4671.52, "end": 4671.9, "word": " one", "probability": 0.9375}, {"start": 4671.9, "end": 4672.7, "word": " or", "probability": 0.94677734375}, {"start": 4672.7, "end": 4673.16, "word": " more", "probability": 0.95556640625}, {"start": 4673.16, "end": 4673.8, "word": " mutant", "probability": 0.99072265625}, {"start": 4673.8, "end": 4674.3, "word": " alleles", "probability": 0.89453125}, {"start": 4674.3, "end": 4674.58, "word": " from", "probability": 0.91259765625}, {"start": 4674.58, "end": 4674.8, "word": " his", "probability": 0.94677734375}, {"start": 4674.8, "end": 4676.34, "word": " parents؟", "probability": 0.80322265625}, {"start": 4676.34, "end": 4676.78, "word": " فشو", "probability": 0.6564127604166666}, {"start": 4676.78, "end": 4677.0, "word": " هذا", "probability": 0.89697265625}, {"start": 4677.0, "end": 4677.14, "word": " الـ", "probability": 0.768310546875}, {"start": 4677.14, "end": 4677.58, "word": " Disease", "probability": 0.45166015625}, {"start": 4677.58, "end": 4677.94, "word": " يا", "probability": 0.89013671875}, {"start": 4677.94, "end": 4678.62, "word": " معتز؟", "probability": 0.75628662109375}], "temperature": 1.0}, {"id": 172, "seek": 470632, "start": 4679.84, "end": 4706.32, "text": "زي ما مدرسي يسأل؟ طيب، إذا أقرأ السؤال بشكل دقيق، شو نسبت إن الـ Probability الـ unborn child will inherit one or more؟ يعني المواحد يعني ما إتنين، القليل اللي هم الـ mutant طيب، إذا شو نسبهم؟ تلت أربعة تلت أربعة، هيك المفروض تلت أربعة، ماشي؟", "tokens": [11622, 1829, 19446, 3714, 3215, 2288, 3794, 1829, 7251, 3794, 10721, 1211, 22807, 23032, 1829, 3555, 12399, 11933, 15730, 5551, 4587, 2288, 10721, 21136, 33604, 6027, 4724, 8592, 28820, 11778, 38436, 4587, 12399, 13412, 2407, 8717, 35457, 2655, 36145, 2423, 39184, 8736, 2310, 2423, 39184, 517, 10324, 1440, 486, 21389, 472, 420, 544, 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/_M5_4TMqxTY.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/_M5_4TMqxTY.srt
new file mode 100644
index 0000000000000000000000000000000000000000..1c4a406794efe72ce3c5866dc627aab2f50010e6
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/_M5_4TMqxTY.srt
@@ -0,0 +1,1818 @@
+1
+00:00:00,000 --> 00:00:09,380
+الآن اليوم راح نتكلم عن الموضوع
+
+2
+00:00:09,380 --> 00:00:13,680
+الثالث من أنواع أو النوع الثالث Third type of
+
+3
+00:00:13,680 --> 00:00:19,400
+genetic diseases أو الـ genetic inheritance اللي هو
+
+4
+00:00:19,400 --> 00:00:24,340
+الـ Complex inheritance of common multifactorial
+
+5
+00:00:24,340 --> 00:00:29,100
+disorders، القصد في الموضوع هذا أنه أحنا أصبحنا
+
+6
+00:00:29,100 --> 00:00:34,460
+أخذنا النوعين اللي هو الـ Chromosomal Diseases أو
+
+7
+00:00:34,460 --> 00:00:39,560
+الـ Subchromosomal Diseases، وهذه النوع، النوع الثاني من
+
+8
+00:00:39,560 --> 00:00:43,280
+الـ  Single Gene Disorders، والآن
+
+9
+00:00:43,280 --> 00:00:46,240
+المجموعة الثالثة اللي هي الأشياء بتكون
+
+10
+00:00:46,240 --> 00:00:49,920
+Multifactorial
+
+11
+00:00:49,920 --> 00:00:54,220
+الجدول
+
+12
+00:00:54,220 --> 00:01:03,380
+الأول يبين لنا أهمية أو نسبة الأمراض اللي فيها
+
+13
+00:01:03,380 --> 00:01:09,380
+جانب وراثي، على ثلاث مراحل في حياة الإنسان أو في
+
+14
+00:01:09,380 --> 00:01:20,340
+حياة البشر، لما نعمل دراسات على حدوثها
+
+15
+00:01:20,340 --> 00:01:25,360
+فبالنسبة
+
+16
+00:01:25,360 --> 00:01:29,580
+للنوع الأول، الـ Chromosomal Mutations أو
+
+17
+00:01:29,580 --> 00:01:34,120
+Chromosomal Diseases، لما بنشوف الـ Incidence at
+
+18
+00:01:34,120 --> 00:01:41,830
+Birth لكل ألف ولادة، نلاقيها تقريباً ستة، والـ
+
+19
+00:01:41,830 --> 00:01:47,470
+بالنسبة للـ due to single gene mutation، بقدر
+
+20
+00:01:47,470 --> 00:01:51,210
+بيكونوا حوالي عشرة، والـ multifactorial
+
+21
+00:01:51,210 --> 00:01:58,530
+inheritance بقدر حوالي خمسين، فهذه يعني النسب
+
+22
+00:01:58,530 --> 00:02:02,790
+المتوقعة، بس يعني الملاحظ بالذات واحد يعني نقارن
+
+23
+00:02:02,790 --> 00:02:12,450
+بعدين اللي هي أنه على عمر الـ 25 سنة، الـ…
+
+24
+00:02:12,450 --> 00:02:16,650
+الـ Chromosomal mutations، الـ Prevalence يعني
+
+25
+00:02:16,650 --> 00:02:22,950
+بالنسبة لحدوثه أو تواجده، بيتلاقيها صارت أقل، يعني
+
+26
+00:02:22,950 --> 00:02:26,990
+فيه احتمالية كبيرة أنه يكون الـ Chromosomal
+
+27
+00:02:26,990 --> 00:02:30,810
+mutation، أن المريض أو الإنسان ما يطول لعمر
+
+28
+00:02:30,810 --> 00:02:37,380
+الـ 25 سنة، والـ Single Gene Mutation برضه بتنزل
+
+29
+00:02:37,380 --> 00:02:41,980
+وبالنسبة للـ Multifactorial Inheritance برضه
+
+30
+00:02:41,980 --> 00:02:46,740
+نسبتها عالية، لما يكون الواحد يأخذ الـ Population
+
+31
+00:02:46,740 --> 00:02:54,700
+بشكل كامل، الأرقام حتى بتختلف بشكل أكبر، الـ Single
+
+32
+00:02:54,700 --> 00:03:00,100
+Gene Mutation أو الـ Chromosomal Mutations، عددها قليل
+
+33
+00:03:01,270 --> 00:03:06,070
+وكذلك الـ Single-Gene، المندلية بتبين أكثر
+
+34
+00:03:06,070 --> 00:03:10,410
+بيصيروا عشرين، بتظهر أشياء أكثر على عمر أكبر شوية
+
+35
+00:03:10,410 --> 00:03:15,870
+وبعدين الـ Multifactorial بيصير إن انفجار فيهم
+
+36
+00:03:15,870 --> 00:03:21,170
+بتضاعف حوالي اثنتا عشرة مرة في الـ General Population
+
+37
+00:03:21,170 --> 00:03:26,090
+لحوالي 600 مرض With Multifactorial Inheritance
+
+38
+00:03:26,090 --> 00:03:32,960
+فصراحةً، أكبر مجموعة هي هذه المجموعة، دورها بيبين أكثر
+
+39
+00:03:32,960 --> 00:03:43,660
+مع تقدم العمر أو زيادة العمر، وهذه القضية بتفرض
+
+40
+00:03:43,660 --> 00:03:49,200
+أهمية العوامل المشتركة بين البيئة وبين الوراثة
+
+41
+00:03:49,200 --> 00:03:56,930
+سويّة، كيف إنهم بتدخلوا في قضية، في قضايا تسبب
+
+42
+00:03:56,930 --> 00:04:02,450
+بالأمراض أكثر بكثير من single gene أو chromosomal
+
+43
+00:04:02,450 --> 00:04:10,910
+mutations، الملاحظ أن كثير من الظواهر الصحية
+
+44
+00:04:10,910 --> 00:04:15,710
+والطبية وغيرها في جسم الإنسان وفي حياة البشر بتكون
+
+45
+00:04:15,710 --> 00:04:19,470
+تتبع المنحنى الطبيعي، اللي هو الـ Normal
+
+46
+00:04:19,470 --> 00:04:23,630
+Distribution، الـ Normal Distribution له أكثر من
+
+47
+00:04:23,630 --> 00:04:30,990
+طريقة، يعني هيك بقول لك زي شكل الجرس، بيكون له شكل
+
+48
+00:04:30,990 --> 00:04:38,960
+معين، الواحد بياخذه ضمن معايير معينة، اللي هو يعني
+
+49
+00:04:38,960 --> 00:04:46,500
+أحياناً يُذكر أنه الـ Distribution أو التوزيع أو
+
+50
+00:04:46,500 --> 00:04:53,920
+الـ أو الـ يعني التوزيع الطبيعي اللي بيكون فيه الـ
+
+51
+00:04:53,920 --> 00:04:57,320
+Mean والـ Median والـ Mode كلها نفس
+
+52
+00:04:57,320 --> 00:05:05,710
+القيمة، يعني المتوسط الحسابي، وأكثر قراءة تحدث
+
+53
+00:05:05,710 --> 00:05:09,850
+والقراءة
+
+54
+00:05:09,850 --> 00:05:14,870
+اللي بالنص تماماً، إذا رتبناهم كلها بتكون قيم
+
+55
+00:05:14,870 --> 00:05:20,690
+متساوية، مثلًا زي هنا مثال على الـ Systolic Blood
+
+56
+00:05:20,690 --> 00:05:27,340
+Pressure، اللي هو ضغط القلب، ضغط الدم الانقباضي، وأنا
+
+57
+00:05:27,340 --> 00:05:33,100
+بأخذ
+
+58
+00:05:33,100 --> 00:05:37,340
+قراءات من عدد كبير من البشر، وألاقيهم ماشيين بهذه
+
+59
+00:05:37,340 --> 00:05:44,200
+الطريقة، الـ Mean بالنصف، الـ one standard deviation
+
+60
+00:05:44,200 --> 00:05:49,660
+يعني انحراف معياري واحد، one standard deviation
+
+61
+00:05:49,660 --> 00:05:59,790
+بيغطي تقريباً 67% من الـ population، يعني تقريباً ثلثي
+
+62
+00:05:59,790 --> 00:06:05,910
+الفرقات بتكون ضمن حوالي الـ Mean بـ One Standard
+
+63
+00:06:05,910 --> 00:06:09,550
+Deviation، لما نحط Two Standard Deviations بنوصل
+
+64
+00:06:09,550 --> 00:06:18,250
+حوالي 95% من الـ Calculation، يعني هذه قيم وأشياء
+
+65
+00:06:18,250 --> 00:06:23,390
+كثيرة من ظواهر الحياة الطبيعية بتلاقيها بتتبع هذا
+
+66
+00:06:23,390 --> 00:06:27,930
+المنحنى، وبتكون ضمن هذا النظام، وبتكون إنه إذا الواحد
+
+67
+00:06:27,930 --> 00:06:31,950
+بعرف الـ Mean والـ Standard Deviation، إن هذولا
+
+68
+00:06:31,950 --> 00:06:40,090
+الرقمين، بتلاقي بيستطيع أنه يعني يتخيل أو يكوّن
+
+69
+00:06:40,090 --> 00:06:45,450
+فكرة أو يرسم صورة عن كيف القراءات راح تكون
+
+70
+00:06:45,450 --> 00:06:48,530
+فبالنسبة
+
+71
+00:06:48,530 --> 00:06:50,830
+للأمراض
+
+72
+00:06:53,330 --> 00:06:59,470
+اللي هي Multifactorial، اللي بتنشأ بسبب تداخلات من
+
+73
+00:06:59,470 --> 00:07:05,770
+جينات عددها كبير، الفكرة اللي بدل واحد ياخدها
+
+74
+00:07:05,770 --> 00:07:12,730
+الأولى إنه، يعني أنا بقول هي من جانبين أو هي من
+
+75
+00:07:12,730 --> 00:07:20,970
+مستويين، أحنا كنا، يعني طبعاً جزء من الموضوع إنه في
+
+76
+00:07:20,970 --> 00:07:30,040
+مشاركة لعدد كبير من الجينات، وفي اختلاف في قوة تأثير
+
+77
+00:07:30,040 --> 00:07:36,620
+البدائل، الـ Alleles الممكنة لكل جين، وبالتالي
+
+78
+00:07:36,620 --> 00:07:47,540
+بيشتركوا في قضية تسبب بالمرض، فمثلًا هنا مثال على
+
+79
+00:07:47,540 --> 00:07:56,210
+موقع افتراضي، جين افتراضي، لما ندرس الأخوين، نلاقي
+
+80
+00:07:56,210 --> 00:08:02,130
+أنّه لمجموعة
+
+81
+00:08:02,130 --> 00:08:06,830
+الجينات
+
+82
+00:08:06,830 --> 00:08:13,810
+نلاقي أنه في تفاوت في البدائل، الأليل الممكنة، أن
+
+83
+00:08:13,810 --> 00:08:18,210
+بعضها بيكون أقوى في التسبب أو في العلاقة مع مرض
+
+84
+00:08:18,210 --> 00:08:25,690
+معين، وبعضها بيكون أضعف، بعضها بيحمي وبعضها بيسبب، وإنه
+
+85
+00:08:25,690 --> 00:08:33,470
+عدد كبير يشترك في التسبب، مثال على ذلك الـ Asthma
+
+86
+00:08:33,470 --> 00:08:41,550
+اللي هو قضية التحسس الهوائي، وتضيق القصبات بشكل
+
+87
+00:08:41,550 --> 00:08:50,100
+متقطع، وكذا نجد إنه بتكون، إذا الواحد درس كم جين
+
+88
+00:08:50,100 --> 00:08:55,980
+بيشترك في التسبب، بتلاقي حوالي ما يقارب الخمسين جين
+
+89
+00:08:55,980 --> 00:09:03,340
+وبيكونوا يعني قوتهم في التسبب، كل واحد اللي هو
+
+90
+00:09:03,340 --> 00:09:08,240
+بمفرده ضعيف، يعني وفي تفاوت في الضعف هذا، بس لما
+
+91
+00:09:08,240 --> 00:09:13,620
+يكون العدد كبير بشكل معين، بتلاقي الرابط بيكون
+
+92
+00:09:13,620 --> 00:09:20,130
+أقوى، أو أقوى، وكذا، فهذه يعني ملاحظة اللي هي أنه عدد
+
+93
+00:09:20,130 --> 00:09:26,650
+كبير من الجينات بتشترك، الظواهر الثانية أحنا كنا
+
+94
+00:09:26,650 --> 00:09:31,470
+أشرنا إليها من قبل، في قضية علم التخلق أو الـ
+
+95
+00:09:31,470 --> 00:09:38,390
+Epigenetics، اللي هي إنه يعني مش فقط التغير
+
+96
+00:09:38,390 --> 00:09:45,230
+البنيوي، التغير الهيكلي للجين، من ناحية أنه قليل
+
+97
+00:09:45,230 --> 00:09:50,310
+بشكل معين، يعني ممكن يعطينا بروتين مختلف، مش بس هذا
+
+98
+00:09:50,310 --> 00:09:55,470
+الاختلاف، الاختلاف الثاني هي في درجة نشاط الجينات
+
+99
+00:09:55,470 --> 00:10:03,730
+يعني ممكن شخصين نفس الجين، نفس الأليل، بس لما يكون
+
+100
+00:10:03,730 --> 00:10:10,530
+نشاط شديد بتلاقي مثلًا المرض موجود، نشاط قليل، المرض
+
+101
+00:10:10,530 --> 00:10:16,610
+مش موجود، بتكون برضه بهذه الطريقة، فقضية التفاوت في
+
+102
+00:10:16,610 --> 00:10:22,070
+نشاط الجينات هذا، اللي هو علم الـ Epigenetics، وإيه
+
+103
+00:10:22,070 --> 00:10:27,230
+اللي دخل، لاحظنا في قضية الـ methylation للـ DNA
+
+104
+00:10:27,230 --> 00:10:32,330
+الـ methylation للـ Histones، الـ microRNAs، البصمة
+
+105
+00:10:32,330 --> 00:10:35,710
+الوراثية اللي هي الـ Parental Imprinting، هذه
+
+106
+00:10:35,710 --> 00:10:38,450
+الأشياء اللي ما فهمناها أو ما كانت للأغلب مش
+
+107
+00:10:38,450 --> 00:10:45,260
+مفهومة، هدول كلها أشكال بتسوّي اختلاف في نشاط
+
+108
+00:10:45,260 --> 00:10:54,760
+الجين، وبالتالي، يعني هذه برضه لها دور ولها تأثير
+
+109
+00:10:54,760 --> 00:11:02,620
+في قضية حدوث الأمراض، لو جينا ناخد، وبصراحة
+
+110
+00:11:02,620 --> 00:11:11,720
+المحاضرة عندكم يعني حاطين أمثلة كثيرة، ما بدنا ندخل
+
+111
+00:11:11,720 --> 00:11:20,620
+فيها، يعني ما بدي، مش هدفنا إنه نطلعكم خبراء بالمجال
+
+112
+00:11:20,620 --> 00:11:31,620
+الموضوع بشكل تفصيلي، عن كم نسبة حدوث مرض معين في
+
+113
+00:11:31,620 --> 00:11:35,220
+إنسان إذا كان حد من أقاربه عنده نفس المشكلة
+
+114
+00:11:37,960 --> 00:11:45,560
+هذه جدول من أحد المراجع بيمثل
+
+115
+00:11:45,560 --> 00:11:50,560
+الـ Relative أو الـ Risk Ratio، اللي هي الإشارة هذه
+
+116
+00:11:50,560 --> 00:11:58,620
+الـ RR، أظن هي اختصارها، أو رؤوس الـ Risk Ratio، هي إذا
+
+117
+00:11:58,620 --> 00:12:05,130
+كان إنسان عنده من أقاربه،
+
+118
+00:12:05,130 --> 00:12:13,410
+يعني من إخوانه
+
+119
+00:12:13,410 --> 00:12:22,250
+وأخواته، مباشرة لشخص مصاب بمرض معين، كم مضاعفات
+
+120
+00:12:22,250 --> 00:12:29,950
+احتمالية أن يصير عنده هذا المرض، مقارنة بغيره، فمثلًا
+
+121
+00:12:29,950 --> 00:12:34,610
+الأمراض النفسية، الـ Schizophrenia أو انفصام
+
+122
+00:12:34,610 --> 00:12:42,650
+الشخصية، إذا أخ أو أخت مصاب بهذا المرض، لشخص غير مصاب،
+
+123
+00:12:42,650 --> 00:12:48,590
+إخوانه وأخواته، احتمالية إصابتهم فيها اثنتا عشرة ضعف
+
+124
+00:12:48,590 --> 00:12:53,690
+من لو ما كانش فيه قرابة أو ما كانش فيه مرض ضمن
+
+125
+00:12:53,690 --> 00:12:58,390
+العائلة، الـ Autism، التوحد، من الأمراض النفسية أو
+
+126
+00:12:58,390 --> 00:13:04,150
+السلوكية، برضه خمسة عشر ضعف، الـ Manic Depressive Bipolar
+
+127
+00:13:04,150 --> 00:13:09,930
+Disorder، برضه من الأمراض النفسية، سبع مرات، السكر
+
+128
+00:13:09,930 --> 00:13:14,270
+النوع الأول، وهو يعتبر يعني مش النوع الوراثة القوية
+
+129
+00:13:14,270 --> 00:13:18,750
+كثير، نسبة الحدوث، ورح نشوف إنها دراسة ثانية
+
+130
+00:13:18,750 --> 00:13:22,190
+بالنسبة
+
+131
+00:13:22,190 --> 00:13:29,070
+لما الإنسان يكون أحد أقاربه أو أحد أشقائه أو شقيقاته
+
+132
+00:13:29,070 --> 00:13:34,090
+مصاب، خمسة وثلاثين ضعف، مرض Crohn's Disease، اللي هو
+
+133
+00:13:34,090 --> 00:13:37,390
+الـ Inflammatory Bowel Disease، من أمراض المناعة
+
+134
+00:13:37,390 --> 00:13:42,690
+الذاتية، على الجهاز الهضمي، خمسة وعشرين ضعف، الـ
+
+135
+00:13:42,690 --> 00:13:46,490
+Multiple Sclerosis أو التصلب اللويحي، أربعة وعشرين
+
+136
+00:13:46,490 --> 00:13:52,990
+ضعف، يعني الملاحظ في كل هذه الأمراض، وراح نأخذ أمثلة
+
+137
+00:13:52,990 --> 00:13:59,170
+كثيرة، أنه مجرد حدوث المرض
+
+138
+00:13:59,170 --> 00:14:04,470
+أو تواجده في العائلة في أحد الأشقاء، برفع نسبة
+
+139
+00:14:04,470 --> 00:14:10,710
+احتمالية حدوثه في الأشقاء الآخرين، بنسبة عالية جداً
+
+140
+00:14:10,710 --> 00:14:16,710
+وهذا تأثير على دور
+
+141
+00:14:16,710 --> 00:14:21,770
+الوراثة في قضية التسبب بمرض معين
+
+142
+00:14:24,310 --> 00:14:32,110
+فكثير من الأمراض لها دور، بس قد يكون قليل، يعني اللي
+
+143
+00:14:32,110 --> 00:14:39,870
+هو أن الأشقاء عادةً بعيشوا مع بعض، وبالتالي بيئتهم
+
+144
+00:14:39,870 --> 00:14:45,490
+متشابهة، فقد يكون هذه النسب وهذه الزيادة قد تكون
+
+145
+00:14:45,490 --> 00:14:53,050
+بسبب نمط حياة معين، بسبب بيئة معينة بتشاركوا فيها
+
+146
+00:14:53,050 --> 00:14:57,430
+وبالتالي زادت النسبة بسبب المشاركة في البيئة، وليس
+
+147
+00:14:57,430 --> 00:15:03,030
+بسبب مشاركة في الجينات، يعني الكثير من الظواهر
+
+148
+00:15:03,030 --> 00:15:09,430
+العامة، يعني مثلًا هنا دراسة عن نسبة الدهون
+
+149
+00:15:09,430 --> 00:15:15,370
+والكوليسترول بين الأمهات والأطفال أو الأبناء
+
+150
+00:15:17,820 --> 00:15:23,480
+يعني عددهم، يعني وأنا الأمهات بين عمر الـ 30 والـ
+
+151
+00:15:23,480 --> 00:15:30,540
+39، والأبناء بين عمر الأربع سنوات والتسع سنوات، وشوف
+
+152
+00:15:30,540 --> 00:15:37,660
+العلاقة بينهم، تقريباً يعني قدرنا نرسم الخط لـ
+
+153
+00:15:37,660 --> 00:15:45,850
+يعني ما يمثل المجمل العلاقات، أنه كل ما كانت الأم
+
+154
+00:15:45,850 --> 00:15:49,730
+الكوليسترول عندها أعلى، الإبن برضه عنده الكوليسترول
+
+155
+00:15:49,730 --> 00:15:55,030
+أعلى، فهذه قضية يعني طبعاً في تفاوت
+
+156
+00:15:55,030 --> 00:16:02,730
+شديد بالنقاط حوالين الخط هذا، بس واضح إنه الواحد
+
+157
+00:16:02,730 --> 00:16:10,390
+بيشوف إنه بشكل عام، كل ما كانت القراءة أوطأ للأم
+
+158
+00:16:10,390 --> 00:16:16,270
+بتكون للطفل أو للإبن أوطأ، وكل ما كانت أعلى بتكون
+
+159
+00:16:16,270 --> 00:16:21,370
+للإبن أعلى، فأحياناً في علاقات، مثل بيانات هذا الشكل
+
+160
+00:16:21,370 --> 00:16:29,490
+اللي بنشوفها، وبالتالي بنصير يعني نقيم تأثير سواء
+
+161
+00:16:29,490 --> 00:16:35,970
+بين قوسين، الوراثة والبيئة
+
+162
+00:16:37,290 --> 00:16:49,110
+درجة حدوث اللي هو في كم عدد المصابين
+
+163
+00:16:49,110 --> 00:16:56,430
+في العائلة، نأخذ هنا مثلًا مثال اللي بيسموها الشفة
+
+164
+00:16:56,430 --> 00:17:03,770
+الأرنبية، الـ Cleft Lip and Palate، اللي هي يعني عيب
+
+165
+00:17:03,770 --> 00:17:10,840
+خلقي، بيكون فيه شق في الشفة العليا، حوالي من الفم
+
+166
+00:17:10,840 --> 00:17:18,560
+وبيكون منظر معروف ومشهور، فهذه الظاهرة إذا أخذنا
+
+167
+00:17:18,560 --> 00:17:31,340
+دراسة، لو كان أخذنا إن إنسان له والد أو والدة واحدة
+
+168
+00:17:31,340 --> 00:17:36,330
+فقط مصابة، ماشي؟ number of affected parents،
+
+169
+00:17:36,330 --> 00:17:41,070
+يا إما صفر، يا إما واحد، يا إما أحيانًا بيحدث إنه
+
+170
+00:17:41,070 --> 00:17:46,770
+اثنين بيتزوجوا عندهم نفس الظاهرة، فإذا كان الأبوان
+
+171
+00:17:46,770 --> 00:17:54,330
+بهذا الترتيب، نجد أنه في أحد هذه الدراسات، وجينا
+
+172
+00:17:54,330 --> 00:18:01,170
+أنا أشوف إنه ما فيش حد، كم عدد اللي بيكونوا مصابين
+
+173
+00:18:01,170 --> 00:18:05,900
+في مثل هذه، يعني إنه إذا كانت العائلة ما عندهاش ولا
+
+174
+00:18:05,900 --> 00:18:16,440
+حد مصاب بشكل مسبق، في حالة إنه
+
+175
+00:18:16,440 --> 00:18:21,120
+ما فيش ولا ولي أمر، أو أب وأم، أو والدين مصابين،
+
+176
+00:18:21,120 --> 00:18:27,640
+احتمالية الإصابة 0.1، يعني اللي هي الـ Risk Ratio
+
+177
+00:18:27,640 --> 00:18:34,060
+بتلاقيها منخفضة نسبيًا جداً، لما يكون أحدهما مصابًا،
+
+178
+00:18:34,060 --> 00
+
+223
+00:23:46,540 --> 00:23:49,000
+«مونوزيجوتيك» أو «دايزيجوتيك» Twin
+
+224
+00:23:49,000 --> 00:23:49,660
+«مونوزيجوتيك» أو «دايزيجوتيك» Twin
+
+225
+00:23:49,660 --> 00:23:50,180
+«مونوزيجوتيك» أو «دايزيجوتيك» Twin
+
+226
+00:23:50,180 --> 00:23:51,500
+«مونوزيجوتيك» أو «دايزيجوتيك» Twin
+
+227
+00:23:51,500 --> 00:23:53,240
+«مونوزيجوتيك» أو «دايزيجوتيك» Twin
+
+228
+00:23:53,240 --> 00:23:56,720
+«مونوزيجوتيك» أو «دايزيجوتيك» Twin
+
+229
+00:23:56,720 --> 00:24:02,040
+«مونوزيجوتيك» أو «دايزيجوتيك» Twin «مونوزيجوت
+
+230
+00:24:02,560 --> 00:24:09,300
+الـ Dizygotic Twins اللي هما يعني كأنه أخوين برضه
+
+231
+00:24:09,300 --> 00:24:14,680
+فيه نسب هي أقل بس بيظل أكبر بكثير من الـ General
+
+232
+00:24:14,680 --> 00:24:22,340
+Population يعني اللي زي ما لاحظنا من قبل في يعني
+
+233
+00:24:22,340 --> 00:24:26,520
+هاي بعتبرها مش كاملة كثير يعني في شيء أنا دائما
+
+234
+00:24:26,520 --> 00:24:32,890
+بعرفه بحفظه وبقول للطلاب، لو أخذنا السكر النوع الأول
+
+235
+00:24:32,890 --> 00:24:38,070
+اللي هو سكر الأطفال اللي بيكون فيه تحطيم للـ Beta
+
+236
+00:24:38,070 --> 00:24:42,620
+Cells  الـبنكرياسي، بيكون فيه نقص إنسولين، وبيصير عندنا
+
+237
+00:24:42,620 --> 00:24:47,820
+مرض السكر النوع الأول أو المؤتمد على الإنسولين،
+
+238
+00:24:47,820 --> 00:24:52,240
+insulin-dependent diabetes mellitus نسبة الـ
+
+239
+00:24:52,240 --> 00:24:56,440
+concordance في الـ monozygotic twins حوالي خمسين
+
+240
+00:24:56,440 --> 00:25:01,040
+بالمئة، أنا هيك بذكر الرقم كانوا يعطونا يعني،
+
+241
+00:25:01,040 --> 00:25:07,340
+بينما لو type 2 diabetes، بيكون نسبة الـ
+
+242
+00:25:07,340 --> 00:25:14,710
+concordance  مئة بالمئة، يعني إذا كان أخوه أو أخته
+
+243
+00:25:14,710 --> 00:25:20,250
+إذا كانت أُختُه أو أخوها أو أخوه، إذا كان ذكور واحد
+
+244
+00:25:20,250 --> 00:25:23,430
+منهم مصاب بالـ Type 2 Diabetes نسبة الـ
+
+245
+00:25:23,430 --> 00:25:28,110
+Concordance 100% فهي يعني، أنا بعتبرها كانت
+
+246
+00:25:28,110 --> 00:25:33,330
+المفروض تكون أقوى، ومؤشر على أن الـGenetics تلعب
+
+247
+00:25:33,330 --> 00:25:38,810
+دوراً في Multifactorial Disorder، فلو
+
+248
+00:25:38,810 --> 00:25:44,800
+نأتي نأخذ القراءات في مناهج دراسة، مش أرقام للحفظ
+
+249
+00:25:44,800 --> 00:25:52,360
+بمعنى الحفظ، بقدر ما أنه فيه تفاوت وفيه نسب اللي
+
+250
+00:25:52,360 --> 00:25:58,740
+بدنا نلاحظها، بس الأهم شيء أنه الـ الـ الـ الـ الـ
+
+251
+00:25:58,740 --> 00:26:04,460
+الـ Dizygotic twins احتمال مؤشر أكثر على تأثير
+
+252
+00:26:04,460 --> 00:26:10,890
+بيئي معين، لأنهم الإخوة والأخوات والعائلة بتعيش في
+
+253
+00:26:10,890 --> 00:26:15,730
+نفس البيئة، في الغالب بيتعرضوا لنفس العوامل الـ
+
+254
+00:26:15,730 --> 00:26:21,810
+Monozygotic twins بيكون أن الدور الوراثي أقوى
+
+255
+00:26:21,810 --> 00:26:27,250
+لأن المادة الوراثية متطابقة تماماً، فبالتالي بنشوف
+
+256
+00:26:27,250 --> 00:26:33,650
+بالنسبة لكثير من الأمراض، نسبة حدوثها أكثر في حالة
+
+257
+00:26:33,650 --> 00:26:37,590
+الـ Monozygotic twins، في حد عنده سؤال؟
+
+258
+00:26:46,850 --> 00:26:52,890
+فهذه إحدى الدراسات عن الموضوع هذا، في دراسة ثانية
+
+259
+00:26:52,890 --> 00:26:56,730
+بشوفها interesting، إن الواحد يعني هيك يتطلع عليها
+
+260
+00:26:56,730 --> 00:27:02,530
+ويشوف شو القيام، وشو اللي بتحكي عنه الآن
+
+261
+00:27:02,530 --> 00:27:08,370
+بالنسبة للوزن، أحسن مؤشر للوزن عشان قضية اختلاف
+
+262
+00:27:08,370 --> 00:27:12,310
+وتفاوت الطول، اللي هو معامل كتلة الجسم اللي هو
+
+263
+00:27:12,310 --> 00:27:19,540
+الـBody Mass Index، الـBody Mass Index هو الوزن
+
+264
+00:27:19,540 --> 00:27:30,840
+بالكيلو على مربع الطول بالمتر، يعني إنسان طوله مثلاً
+
+265
+00:27:30,840 --> 00:27:38,460
+نقول متر وسبعين سنتيمتر، نقسم وزنه ثمانين كيلو، ثمانين
+
+266
+00:27:38,460 --> 00:27:42,200
+كيلو، بقول بقسم ثمانين على 1.7 في 1.7
+
+267
+00:27:42,200 --> 00:27:48,130
+بكون له معادلة معينة، هذا المعامل
+
+268
+00:27:48,130 --> 00:27:52,750
+إنه بيعطيك أرقام معروفة، مثلاً من 19 لـ 25 هذا
+
+269
+00:27:52,750 --> 00:27:58,950
+الإنسان الطبيعي، من 25 لـ 30 فيه زيادة وزن شوية
+
+270
+00:27:58,950 --> 00:28:06,730
+يعني بيقولوا له overweight شوية، من 30 لـ 40 سمنة، فيه
+
+271
+00:28:06,730 --> 00:28:11,580
+عنده obesity، فوق الأربعين بيقولوا له «morbidly
+
+272
+00:28:11,580 --> 00:28:16,560
+obese»، يعني مريض جداً جداً بشكل سمنة مرضية قاتلة
+
+273
+00:28:16,560 --> 00:28:24,300
+فلما نيجي نأخذ في هذه الدراسة، حاولوا يفرقوا بين
+
+274
+00:28:24,300 --> 00:28:27,980
+الـ «مونوزيجوتيك» والـ «دايزيجوتيك» Twin types
+
+275
+00:28:27,980 --> 00:28:35,680
+يعني حاولوا يدرسوا فيها، ودرسوا الذكور والإناث، أو
+
+276
+00:28:35,680 --> 00:28:41,280
+الـ «ميلز» والـ «فيميلز»، Men and Women ودرسوا قضية
+
+277
+00:28:41,280 --> 00:28:46,100
+هل عاشوا مع بعض، عايشين مع بعض، ولّا مفرقين، إذا
+
+278
+00:28:46,100 --> 00:28:53,100
+بعيشوا together يعني، يعني عايشين في نفس البيت
+
+279
+00:28:53,100 --> 00:28:57,200
+بيأكلوا من نفس الأكل، بعيشوا نفس الطريقة، بيركبوا
+
+280
+00:28:57,200 --> 00:29:02,560
+نفس السيارة مثلاً، بيروحوا ماشيين قريبين من بعض، إذا
+
+281
+00:29:02,560 --> 00:29:08,570
+عايشين apart يعني مربيين في بيئات مختلفة، ممكن إنه
+
+282
+00:29:08,570 --> 00:29:15,850
+فيه تفاوت في البيئة يكون أكثر، فهو راح يعطينا عدد
+
+283
+00:29:15,850 --> 00:29:24,930
+الأزواج من التوائم وأنواعها بالنسبة لكل مرحلة من
+
+284
+00:29:24,930 --> 00:29:34,450
+الدراسة، هنا للـ Women، وهنا للـ Men، وهنا معامل
+
+285
+00:29:34,450 --> 00:29:43,490
+التطابق، ماشي، بالنسبة للـ «مونوزيجوتيك»
+
+286
+00:29:43,490 --> 00:29:53,110
+نلاحظ أنه لما يكونوا «مونوزيجوتيك»، ويكونوا يعني
+
+287
+00:29:53,110 --> 00:29:59,310
+الذكور أو الإناث، النسب تقريباً الثلثين أو أكثر، 74
+
+288
+00:29:59,310 --> 00:30:08,430
+%، طبعاً الـ 70% لما نتربّوا في أماكن مختلفة، وبالنسبة
+
+289
+00:30:08,430 --> 00:30:13,470
+لما نعيشوا مع بعض، حتى 75% يعني تقريباً قريبين جداً
+
+290
+00:30:13,470 --> 00:30:19,130
+من بعض، بينما الـ Dizygotic Twins كأخوة وأخوات
+
+291
+00:30:19,130 --> 00:30:25,390
+مختلفين، النسب أقل بكثير، فبنقدر الواحد يقول، وهذه
+
+292
+00:30:25,390 --> 00:30:30,100
+الملاحظة، قطعاَ الجهة الثانية، النسب أقل بكثير، إنه
+
+293
+00:30:30,100 --> 00:30:33,360
+يعني الواحد اللي بدي أقوله، إنه الوراثة بتلعب دور
+
+294
+00:30:33,360 --> 00:30:39,060
+كبير، يعني الدور الأعظم، هي لقضية الوراثة، إن حجم
+
+295
+00:30:39,060 --> 00:30:43,860
+الواحد أو وزنه بيكون بشكل معين، وإن فيه نسبة كبيرة
+
+296
+00:30:43,860 --> 00:30:48,500
+من العامل الوراثي، لو قارنا الـ Apart عن Together
+
+297
+00:30:48,500 --> 00:30:54,610
+بكل هذه الأمثلة، بلاحظ أنه فيه نسبة، لما يكونوا together،
+
+298
+00:30:54,610 --> 00:31:01,390
+نسبة التطابق بتكون أكبر، أقرب لبعض، ماشي، بالذات
+
+299
+00:31:01,390 --> 00:31:06,650
+بالنسبة للذكور أكثر من الإناث، بس كلها تقريباً،
+
+300
+00:31:06,650 --> 00:31:14,810
+يعني نسب ضئيلة، هنا 4%، هنا صارت 18%، بس هنا 2% و
+
+301
+00:31:14,810 --> 00:31:20,310
+0%، فرق بين أنه عايشين مع بعض أو يعني، اللي بنقدر
+
+302
+00:31:20,310 --> 00:31:27,250
+نستنتجه من هذه، مثل هذه الأرقام، أنه نقول إنه الوراثة
+
+303
+00:31:27,250 --> 00:31:32,710
+لها دخل، بس نسبة بسيطة، الوراثة اللي هو يعني
+
+304
+00:31:32,710 --> 00:31:38,230
+«monozygotic» أو «dizygotic twins» لها أهمية كبيرة
+
+305
+00:31:38,230 --> 00:31:43,980
+بس البيئة بتلعب دور ثانوي أو بسيط، أو يعني هو شيء
+
+306
+00:31:43,980 --> 00:31:51,360
+مؤثر، بس درجته بسيطة، بالنسبة لعامل قضية الوزن
+
+307
+00:31:51,360 --> 00:31:57,560
+بين الذكور والإناث، فهي ملاحظة يعني، إنه الوزن نقدر
+
+308
+00:31:57,560 --> 00:32:04,320
+نستنتج بهذه الطريقة، إنه نسبة كبيرة من وزن الإنسان
+
+309
+00:32:04,320 --> 00:32:11,900
+يحدده وراثته، وفيه جينات بتتدخل في هذا الموضوع، وهي
+
+310
+00:32:11,900 --> 00:32:19,620
+اللي بتكون مؤثرة عليه، البيئة بحيث إنه كيف كانوا
+
+311
+00:32:19,620 --> 00:32:27,440
+عايشين، وشو بيئتهم، لها دور، بس نسبته قليلة، ويعني
+
+312
+00:32:27,440 --> 00:32:34,660
+تأثيره أضعف بكثير من تأثير الوراثة، والوراثة كمان
+
+313
+00:32:34,660 --> 00:32:39,900
+بالـ «مونوزيجوتك توينز» أقوى من الـ «دايزيجوتك
+
+314
+00:32:39,900 --> 00:32:48,220
+توينز»، يعني إنها بشكل ملحوظ، فهي كلها أمثلة على
+
+315
+00:32:48,220 --> 00:33:01,040
+خواص طبية وجسمانية، في جوانب مختلفة، على قضية التأثير
+
+316
+00:33:01,750 --> 00:33:07,750
+الوراثة والبيئة، من خلال عدد كبير من الجينات، ما فيش
+
+317
+00:33:07,750 --> 00:33:11,570
+جين محدد، it's not dominant أو recessive زي ما كنا
+
+318
+00:33:11,570 --> 00:33:15,910
+نتكلم في الـMandelian Inheritance، ولا هي زي
+
+319
+00:33:15,910 --> 00:33:21,970
+الـChromosomal Diseases اللي كنا نحكي عنها الآن
+
+320
+00:33:21,970 --> 00:33:30,830
+حطينا أيضاً أمثلة على أهمية الـ
+
+321
+00:33:34,870 --> 00:33:40,390
+الأمراض والحالات اللي بتدخل فيها الـ
+
+322
+00:33:40,390 --> 00:33:44,750
+Multifactorial Inheritance، بتدخل فيها عدد كبير من
+
+323
+00:33:44,750 --> 00:33:49,970
+الجينات، فالـ Cleft Lip و Cleft Palate، الـ
+
+324
+00:33:49,970 --> 00:33:54,500
+Congenital Heart Diseases، أو الـ Neural Tube
+
+325
+00:33:54,500 --> 00:33:58,840
+Defects، أو الـ Spina Bifida، أو الـ Anencephaly، أو
+
+326
+00:33:58,840 --> 00:34:04,180
+التشوهات، أو الـ Biliary Atresia، هنا بتتكلموا على
+
+327
+00:34:04,180 --> 00:34:09,660
+Approximate Population Incidence لكل ألف بني آدم
+
+328
+00:34:09,660 --> 00:34:17,840
+كم نسبة الحالات هذه، ويعني بالنسبة لمثل هذه الأشياء
+
+329
+00:34:17,840 --> 00:34:19,900
+يعني
+
+330
+00:34:22,190 --> 00:34:28,150
+مرة أخرى، عدد كبير من الجينات بتدخل فيها، مرات
+
+331
+00:34:28,150 --> 00:34:31,390
+بيقعدوا يبحثوا فيها، بالذات إذا في عائلة معينة
+
+332
+00:34:31,390 --> 00:34:35,270
+عندها مشكلة معينة أكثر من غيرها، أقوى من غيرها
+
+333
+00:34:35,270 --> 00:34:43,150
+والشغل الثاني، بدي الواحد يتذكر أنه أحياناً البيئة
+
+334
+00:34:43,150 --> 00:34:48,450
+برضه لها دخل، يعني الـSpina Bifida يعني من الحالات
+
+335
+00:34:48,450 --> 00:34:54,110
+أو الأمراض مثلاً، العمل القائم لها دخل كبير بنقص
+
+336
+00:34:54,110 --> 00:34:58,610
+الـ «فولات» في التغذية عند الحمل، في الحوامل، عشان
+
+337
+00:34:58,610 --> 00:35:02,670
+هيك، إذا بتتم تعويض الـ «فولات» مع الحديد عادةً
+
+338
+00:35:02,670 --> 00:35:07,350
+عشان يعني الدم، نتكلم عنها، بس أظن فيه دراسات قوية
+
+339
+00:35:07,350 --> 00:35:13,230
+إن الـ «سباينا» بتقل إذا الواحد بيفرض في المجتمع
+
+340
+00:35:13,230 --> 00:35:20,600
+إنه يعطي تعويض للحوامل في قضية
+
+341
+00:35:20,600 --> 00:35:24,560
+الـ Folic Acid، في أحد الفيتامينات اللي بيكون
+
+342
+00:35:24,560 --> 00:35:29,920
+فيه نقص، الـ Neural Tube Defect بتقل كثير، ويكون
+
+343
+00:35:29,920 --> 00:35:36,600
+فيه اكتمال بناء الجهاز العصبي، فهذه أمثلة على حالات
+
+344
+00:35:36,600 --> 00:35:46,590
+وبتكون فيها Multifactorial، أنا بظن أن الأرقام
+
+345
+00:35:46,590 --> 00:35:59,870
+والتفاصيل، بالنسبة لقد أيش احتمالية حدوث شيء في حالة
+
+346
+00:35:59,870 --> 00:36:06,350
+وجوده في أحد الأقارب، أو في أحد الإخوة، وقد إيش نسبته
+
+347
+00:36:06,350 --> 00:36:11,110
+أكثر بتزيد، وكذا وكذا، ما بدنا إياها، بقدر ما أنه
+
+348
+00:36:11,110 --> 00:36:18,260
+نأخذ أن هذه أمثلة على حالة، عبارة عن لها دخل
+
+349
+00:36:18,260 --> 00:36:24,080
+بالنسبة للوراثة، بالنسبة للـ Congenital Heart
+
+350
+00:36:24,080 --> 00:36:29,980
+Diseases، الـ Tetralogy of Fallot اللي هو رُباعية
+
+351
+00:36:29,980 --> 00:36:37,980
+Fallot، أربع ظواهر، Aortic Stenosis، Ventricular
+
+352
+00:36:37,980 --> 00:36:43,130
+Septal Defect، Overriding of the Aorta، الـ Pulmonary
+
+353
+00:36:43,130 --> 00:36:46,710
+valve
+
+354
+00:36:46,710 --> 00:36:54,410
+stenosis، والـ Atrial septal defect، يعني أربع ظواهر بخربط
+
+355
+00:36:54,410 --> 00:37:00,750
+الدموي بهذا الشكل، بيصير سيانوسس، بيصير خربطات
+
+356
+00:37:00,750 --> 00:37:06,350
+بالنسبة للقلب بشكل كبير جداً، Hypoplastic left
+
+357
+00:37:06,350 --> 00:37:12,010
+ventricle، يعني فيه مشكلة إنه تكون الـ left
+
+358
+00:37:12,010 --> 00:37:16,870
+ventricle بيصير ضعيف، في حالة بيسموها Atrial septal
+
+359
+00:37:16,870 --> 00:37:24,270
+defect، عبارة عن الفتحة بين الأذينين اليمين واليسار
+
+360
+00:37:24,270 --> 00:37:30,610
+اللي هي بتكون أصلاً مهمة في حالة الـ في المرحلة
+
+361
+00:37:30,610 --> 00:37:35,050
+الجنينية، المرحلة الجنينية، يعني إحنا ما عندناش lungs
+
+362
+00:37:35,050 --> 00:37:40,250
+تاخد الأكسجين، والجنين في بطن أمه وفي الرحم، فالـ
+
+363
+00:37:40,250 --> 00:37:45,430
+Oxygenated blood بيجي من الـ umbilical vein، بيرجع
+
+364
+00:37:45,430 --> 00:37:53,670
+من الـ umbilical artery، من المشيمة، فالـ Oxygenated blood
+
+365
+00:37:53,670 --> 00:38:00,910
+اللي هو بيجي عن طريق الـ، يعني هنا بدّه يرجع للقلب
+
+366
+00:38:00,910 --> 00:38:07,940
+على الجهة اليمين عادي، بيروح بالإنسان الطبيعي، بدخل
+
+367
+00:38:07,940 --> 00:38:11,260
+من الـInferior Vena Cava، بيروح على طول على الـRight
+
+368
+00:38:11,260 --> 00:38:13,880
+Atrium، على الـRight Atrium، بعدين على الـLeft
+
+369
+00:38:13,880 --> 00:38:17,180
+Atrium، بعدين على الـBody، هذا اللي هو الدم
+
+370
+00:38:17,180 --> 00:38:21,060
+الكويس، بتكون بهذا الشكل، Coarctation of the
+
+371
+00:38:21,060 --> 00:38:26,740
+aorta، برضه يعني ممكن تكون Patent ductus
+
+372
+00:38:26,740 --> 00:38:32,220
+arteriosus، هذول يعني برضه من الظواهر، هنا فيه
+
+373
+00:38:32,220 --> 00:38:39,600
+تضيق في الأورطة
+
+374
+00:38:39,600 --> 00:38:44,800
+بعد الـ left subclavian، وتكون على الـ anatomical site
+
+375
+00:38:44,800 --> 00:38:49,360
+تبع الدكتوس أرتيريوسس، تبع الدكتوس أرتيريوسس، هذه النقطة
+
+376
+00:38:49,360 --> 00:38:53,400
+الثانية اللي بتتم فيها تحويلات الدم في الفترة
+
+377
+00:38:53,400 --> 00:38:58,000
+الجنينية، لما الإنسان يولد، كل هذه المفروض تسكر، فإذا
+
+378
+00:38:58,000 --> 00:39:02,280
+ما سكرتش، أو سكرت زيادة، بتعمل مرض، الـ Coarctation
+
+379
+00:39:02,280 --> 00:39:04,920
+of the aorta، بدّه يخلي الإنسان عنده ارتفاع في
+
+380
+00:39:04,920 --> 00:39:09,380
+الضغط في الأطراف العلوية، وبالرجلين الضغط بيكون
+
+381
+00:39:09,380 --> 00:39:14,760
+واطئ جداً، لأن الدم مش قادر ينضخ بشكل سليم، والـ
+
+382
+00:39:14,760 --> 00:39:19,220
+Patent ductus arteriosus راح يخلي هبوط في الدورة
+
+383
+00:39:19,220 --> 00:39:26,420
+الدموية، بسبب اختلاط الدم بين الدورة الكبرى والصغرى
+
+384
+00:39:26,420 --> 00:39:32,590
+وتكون بشكل متعب للقلب، بسبب، يعني إنه بيشتغل على
+
+385
+00:39:32,590 --> 00:39:38,350
+الفاضي، واختلال في دورة الدم، فهذه كلها حالات فيها
+
+386
+00:39:38,350 --> 00:39:47,190
+منها لها دخل بالنسبة للوراثة، ويعني اللي
+
+387
+00:39:47,190 --> 00:39:52,910
+هي بيسموها الـ Risk Ratio، كمعامل بيعطينا كم مرة
+
+388
+00:39:52,910 --> 00:39:57,030
+أكثر من غيره، إذا كان لدى أحد في العائلة مشكلة
+
+389
+00:39:57,030 --> 00:40:00,950
+بالنسبة
+
+390
+00:40:00,950 --> 00:40:07,890
+للـ Population، إذا كان لدى أحد في العائلة مشكلة
+
+391
+00:40:07,890 --> 00:40:13,630
+بالنسبة للحدوث في أب
+
+445
+00:46:06,040 --> 00:46:13,620
+وبروثرومبين، اللي هو الـFactor 2، اللي هو الرقم 2،
+
+446
+00:46:13,620 --> 00:46:19,270
+ماشي، برضه الـFibrinogen Variant رقم 1
+
+447
+00:46:19,270 --> 00:46:22,650
+فالتفاوت
+
+448
+00:46:22,650 --> 00:46:31,050
+في الـVariation بالنسبة للـClotting Factors
+
+449
+00:46:31,050 --> 00:46:35,610
+اللي له تداخل كمان بالـEnvironmental Genetics
+
+450
+00:46:35,610 --> 00:46:40,070
+Factors مثال عليها كـEnvironmental Factors أحد
+
+451
+00:46:40,070 --> 00:46:43,370
+أهم أسباب التجلطات اللي هو استخدام الـOral
+
+452
+00:46:43,370 --> 00:46:51,410
+Contraceptive Pills اللي هو الحبوب المانعة للحمل كهرمون
+
+453
+00:46:51,410 --> 00:46:59,650
+ثيرابي عشان يمنع الحمل، فالفكرة
+
+454
+00:46:59,650 --> 00:47:01,530
+في الموضوع أنه
+
+455
+00:47:05,490 --> 00:47:12,810
+حسب الـGenetic Factors والـGenetic Status
+
+456
+00:47:12,810 --> 00:47:18,450
+وبعده بشكل متعدد العوامل
+
+457
+00:47:18,450 --> 00:47:22,990
+البيئية زي الـOral Contraceptives بتلاقي لها دخل
+
+458
+00:47:22,990 --> 00:47:27,160
+إنه بيعمل مشاكل في الـFactor 10 اللي ما حطينا لكم
+
+459
+00:47:27,160 --> 00:47:31,740
+إياها والـProthrombin اللي هو Factor 2 هدول
+
+460
+00:47:31,740 --> 00:47:36,880
+ازدادوا بشكل كبير مع بعض الـVariants of them مع
+
+461
+00:47:36,880 --> 00:47:41,980
+الـOral Contraceptives فهي بتسبب إنه
+
+462
+00:47:41,980 --> 00:47:46,040
+«hypercoagulable state» يعني بتسبب إنه راح تسمح
+
+463
+00:47:46,040 --> 00:47:51,700
+بأن يصير جلطات وتصير مشاكل بسبب
+
+464
+00:47:51,700 --> 00:47:58,660
+تداخل عوامل وراثية وعوامل بيئية، من الآن الأشياء
+
+465
+00:47:58,660 --> 00:48:02,060
+اللي تعتبر قوية في الأماكن هذه، في عند الواحد مجال
+
+466
+00:48:02,060 --> 00:48:11,340
+لدراستها، اللي هو تأثير الـWarfarin على الـ
+
+467
+00:48:11,340 --> 00:48:15,460
+طبعاً الـWarfarin هو Blocker للـVitamin K اللي
+
+468
+00:48:15,460 --> 00:48:20,560
+هو بيثبت الـVitamin K dependent factors والواحد
+
+469
+00:48:20,560 --> 00:48:28,600
+بيحفظه كمعادلة أو كرقم 1972 فعشرة أو تسعة أو سبعة
+
+470
+00:48:28,600 --> 00:48:31,900
+أو اثنين، كل الـfactors تبعات الـCoagulation
+
+471
+00:48:31,900 --> 00:48:36,260
+factors produced by the liver، بتم إنتاجها من الكبد
+
+472
+00:48:36,740 --> 00:48:41,620
+والأربعة هذول Vitamin K-dependent طبعاً، زائد بروتين
+
+473
+00:48:41,620 --> 00:48:47,380
+C وبروتين S، فالآن فيه side effect قوي وبتصير مشاكل
+
+474
+00:48:47,380 --> 00:48:52,100
+من الـWarfarin إذا فيه certain genetic mutation
+
+475
+00:48:52,100 --> 00:48:56,560
+فحتى من الآن اللي يسمونه personalized medicine
+
+476
+00:48:56,560 --> 00:49:04,140
+الأصل أنه يعني يدوروا على الـGenetic mutations هذه
+
+477
+00:49:04,600 --> 00:49:07,900
+وإذا فعلاً الإنسان عنده إياها
+
+478
+00:49:07,900 --> 00:49:14,940
+ما يعطوه الـWarfarin، وبتأثر على كمية أو كيفية معالجته بالنسبة
+
+479
+00:49:14,940 --> 00:49:19,780
+للـCarbohydrate Factors، في أسئلة؟ في حالة اسمها Hirschsprung
+
+480
+00:49:19,780 --> 00:49:28,540
+Disease، Hirschsprung Disease من أمراض الجهاز الهضمي
+
+481
+00:49:28,540 --> 00:49:36,060
+والـMotility تبعت الجهاز الهضمي برضه، اللي له دخل
+
+482
+00:49:36,060 --> 00:49:40,680
+بالبيئة وكمان أمراض كثيرة زي الـType 1 Diabetes،
+
+483
+00:49:40,680 --> 00:49:47,560
+الـAlzheimer وDementia
+
+484
+00:49:47,560 --> 00:49:51,780
+الـAlzheimer وDementia
+
+485
+00:49:51,780 --> 00:50:02,000
+كيف إنه عدد كبير من الـGenotypes، جينات متعددة
+
+486
+00:50:02,400 --> 00:50:08,980
+طبعاً يعني مثلًا موضوع زي الـAlzheimer اللي هو
+
+487
+00:50:08,980 --> 00:50:13,900
+الأصل يعني اللي واحد يتذكره كـPresenile Dementia
+
+488
+00:50:13,900 --> 00:50:19,900
+يعني الخرف المبكر، الإنسان
+
+489
+00:50:19,900 --> 00:50:28,940
+حسب بيئته، حسب جيناته، حسب شو هو، بتلاقي فيه تفاوت
+
+490
+00:50:28,940 --> 00:50:36,620
+في نسبة حدوث هذه الحالة، وبتلاقي تعتمد
+
+491
+00:50:36,620 --> 00:50:45,700
+حسب يعني عدد مش قليل من الـmutations وكذا
+
+492
+00:50:45,700 --> 00:50:50,600
+ولكن أيضًا له دخل بالبيئة، يعني زي ما دائمًا بيحكوا
+
+493
+00:50:50,600 --> 00:50:54,760
+كثير، إذا مثلًا واحد بيحفظ قرآن، إذا الواحد دائمًا
+
+494
+00:50:54,760 --> 00:51:00,880
+بينشط عقله، مثلًا بيلعب لعبة زي اللي فيها رياضيات
+
+495
+00:51:00,880 --> 00:51:06,180
+وتفكير وحساب، زي لعبة سودوكو مثلًا، ودائمًا بيظل
+
+496
+00:51:06,180 --> 00:51:14,440
+يمرن عقله، الإنسان بتلاقي بتأخر حدوث الخرف وبيظل
+
+497
+00:51:14,440 --> 00:51:20,370
+محافظ على قوة العقلية مدة أطول، أحيانًا زي ذلك، فكل
+
+498
+00:51:20,370 --> 00:51:29,910
+الأشياء أمثلة على أمراض وحالات بيكون
+
+499
+00:51:29,910 --> 00:51:34,170
+الصفة
+
+500
+00:51:34,170 --> 00:51:42,550
+الأغلب فيها والأعم هي أنها تشترك فيها جوانب
+
+501
+00:51:42,550 --> 00:51:50,820
+وراثية وجوانب جينية بطرق مختلفة ومتفاوتة ومتعددة مع
+
+502
+00:51:50,820 --> 00:51:55,220
+عوامل بيئية، بتلاقيها في البيئة، في أشياء معينة
+
+503
+00:51:55,220 --> 00:51:59,860
+بتخلي الواحد يصير عنده، فبالنسبة لمحاضرة اليوم هذه
+
+504
+00:51:59,860 --> 00:52:09,460
+الأشياء اللي أمثل عليها، يعني أنا بظن إن الواحد إذا
+
+505
+00:52:09,460 --> 00:52:15,060
+بده يركز شوية على إن الأمراض الكروموسومية يحفظها
+
+506
+00:52:15,060 --> 00:52:22,670
+مظبوط لأن عددها قليل وأمثلتها قليلة، بالذات الرئيسية
+
+507
+00:52:22,670 --> 00:52:28,770
+منها، وبالنسبة لـ"ماندالين" يتكلم عن المشهورات منها
+
+508
+00:52:28,770 --> 00:52:36,130
+المعرفات والأساسيات، وبالنسبة للمجموعة الكبرى يعني
+
+509
+00:52:36,130 --> 00:52:43,270
+كل الأسماء الأمراض اللي عرضناها، يتذكر الواحد إنه
+
+510
+00:52:43,270 --> 00:52:45,570
+Multifactorial
+
+511
+00:52:46,510 --> 00:52:51,090
+ما دخلناش كثير في أمثلة، مثلًا مثلًا مثلًا
+
+512
+00:52:51,090 --> 00:52:51,650
+مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا
+
+513
+00:52:51,650 --> 00:52:56,810
+مثلًا مثلًا مثلًا مثلًا مثلًا
+
+514
+00:52:56,810 --> 00:53:01,150
+مثلًا
+
+515
+00:53:01,150 --> 00:53:02,270
+مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا
+
+516
+00:53:02,270 --> 00:53:03,410
+مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا
+
+517
+00:53:03,410 --> 00:53:13,030
+مثلًا مثلًا
+
+518
+00:53:13,030 --> 00:53:19,260
+مثلًا الـWhole Genome Sequencing، يعني أنه تقدر
+
+519
+00:53:19,260 --> 00:53:25,780
+الواحد يقرأ شو النيوكليوتيدات تبع كل الـDNA تبع أي
+
+520
+00:53:25,780 --> 00:53:34,400
+إنسان، ماشي، بصير تعطيني يعني مرجع إن إذا أنا عندي
+
+521
+00:53:34,400 --> 00:53:40,460
+عائلة كبيرة مثلًا أو مجموعة معينة من البشر بيكون
+
+522
+00:53:40,460 --> 00:53:46,180
+أقدر أقارن بين المصابين وغير المصابين، ليش هذا أصيب
+
+523
+00:53:46,180 --> 00:53:52,600
+وليش هذا لم يصيب، في الـWhole Genome Sequencing من
+
+524
+00:53:52,600 --> 00:53:58,520
+أحد التقنيات اللي راحت تشوفوا إنها بتقدر تفيدنا
+
+525
+00:53:58,520 --> 00:54:09,180
+وفي جانب آخر، قضية دراسة كمية شغل الجين، يعني مش
+
+526
+00:54:09,180 --> 00:54:14,420
+كل الجينات في كل الخلايا شغالة بنفس الدرجة، لأ،
+
+527
+00:54:14,420 --> 00:54:18,400
+حسب مثلًا الجين تبع الهيموجلوبين، بضرب دائمًا
+
+528
+00:54:18,400 --> 00:54:22,720
+مثال بس، في الـRed Blood Cells بيكون شغال، في باقي
+
+529
+00:54:22,720 --> 00:54:27,900
+الخلايا ما له دخل، بقى بتم استخدامه، فحتى بالنسبة
+
+530
+00:54:27,900 --> 00:54:33,860
+للهيموجلوبين، الجين، درجة فعليته، كم نسخة RNA
+
+531
+00:54:33,860 --> 00:54:40,330
+ناتج عنه، فبالتالي، يعني ممكن الإنسان العالم يعني
+
+532
+00:54:40,330 --> 00:54:45,510
+قصدي في الدراسة نشوف اختلاف أو تفاوت في نشاط
+
+533
+00:54:45,510 --> 00:54:48,250
+الجينات، اللي هو يعني الـEpigenetic Control اللي
+
+534
+00:54:48,250 --> 00:54:56,750
+حكينا عنه، هذه لها طرق دراسة معينة، ممكن نتيجتها
+
+535
+00:54:56,750 --> 00:55:02,730
+الواحد يكون يعرف إيش الجينات المسؤولة بنشاطها عن
+
+536
+00:55:02,730 --> 00:55:09,030
+حدوث مرض معين، يعني هذه الـ الـ يعني الـgene
+
+537
+00:55:09,030 --> 00:55:18,510
+expression بتكون إنه إحنا بندرس بشكل عام درجة نشاط
+
+538
+00:55:18,510 --> 00:55:25,260
+الجينات، كلها بمين اللي زايدات ومين اللي ناقصات، هذه
+
+539
+00:55:25,260 --> 00:55:31,400
+بتكون باستخدام Markers معينة، وبتكون أساليب دراسة
+
+540
+00:55:31,400 --> 00:55:38,920
+لما واحد يقرأ عنها بتلاقيها ممكن تكون مفيدة، فاليوم
+
+541
+00:55:38,920 --> 00:55:44,620
+المحاضرة قصيرة، ما فيها أفكار كثيرة بالنسبة
+
+542
+00:55:44,620 --> 00:55:51,400
+لـ يعني بالنسبة لـ أن المطلوب بالنسبة للجينات
+
+543
+00:55:51,400 --> 00:55:55,630
+لهذه الأمراض، لأ، ما بندخلهش كثير كثير يعني
+
+544
+00:55:55,630 --> 00:56:00,430
+بالنسبة لشو هي، بقدر ما إنه فيه عدد كبير من الجينات
+
+545
+00:56:00,430 --> 00:56:03,870
+يعني أقل واحد واللي حطوا عنه مثال اللي هو الـ
+
+546
+00:56:03,870 --> 00:56:08,010
+Retinitis Pigmentosa، إنه فيها جينين عاملين مشكلة
+
+547
+00:56:08,010 --> 00:56:11,430
+فيه
+
+548
+00:56:11,430 --> 00:56:18,650
+أسئلة؟ أسئلة عن الجزء هذا أو الأجزاء السابقة؟
+
+549
+00:56:31,300 --> 00:56:39,220
+هنا، دعونا نشوف، Remote Control، Chat،
+
+550
+00:56:39,220 --> 00:56:47,860
+ماشي، دكتور أحمد، في أسئلة؟ اليوم، الحلقة أقصر من
+
+551
+00:56:47,860 --> 00:56:54,620
+غيرها شوية، أصل مفاهيمها يعني، الحمد لله، يعني
+
+552
+00:56:54,620 --> 00:56:57,700
+مطلوب المعلومة العامة يعني، آه
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/_M5_4TMqxTY_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/_M5_4TMqxTY_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..a98d2d47aa0b947f1e5193f75ef249ac165985bd
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/_M5_4TMqxTY_raw.json
@@ -0,0 +1 @@
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الـ Tetralogy of Fallot اللي هو ربعية Fallot أربع ظواهر Aortic Stenosis Ventricular Septal Defect Overriding of the Aorta", "tokens": [5016, 6027, 3660, 6225, 3555, 9640, 3660, 18871, 11933, 1829, 11296, 11778, 9778, 1211, 20666, 1863, 35457, 3660, 24976, 13063, 5718, 104, 3660, 20666, 1863, 35457, 3660, 24976, 39184, 2656, 1766, 1686, 13569, 30161, 1957, 2423, 39184, 31580, 2155, 7794, 295, 7465, 310, 13672, 1829, 31439, 12602, 3555, 3615, 10632, 7465, 310, 5551, 25513, 3615, 1357, 116, 14407, 3224, 2288, 316, 48816, 745, 268, 8211, 28290, 42750, 6978, 304, 1346, 1836, 4886, 81, 2819, 295, 264, 316, 36403], "avg_logprob": -0.22844145909140381, "compression_ratio": 1.3282828282828283, "no_speech_prob": 0.0, "words": [{"start": 2174.46, "end": 2175.14, "word": "حالة", "probability": 0.794189453125}, {"start": 2175.14, "end": 2176.88, "word": " عبارة", "probability": 0.8385009765625}, {"start": 2176.88, "end": 2177.18, "word": " عن", "probability": 0.98876953125}, {"start": 2177.18, 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"word": " Defect", "probability": 0.95703125}, {"start": 2199.14, "end": 2200.78, "word": " Overriding", "probability": 0.8956705729166666}, {"start": 2200.78, "end": 2201.04, "word": " of", "probability": 0.9501953125}, {"start": 2201.04, "end": 2201.18, "word": " the", "probability": 0.83349609375}, {"start": 2201.18, "end": 2201.66, "word": " Aorta", "probability": 0.7822265625}], "temperature": 1.0}, {"id": 82, "seek": 222757, "start": 2202.57, "end": 2227.57, "text": "الـ Pulmonary valve stenosis والـ Atrial alarm يعني أربع ظواهر بخربط الدموي بهذا الشكل بيصير سيانوسس بيصير خربطات بالنسبة للقلب بشكل كبير كثير Hypoplastic lymph vent heart", "tokens": [6027, 39184, 35568, 46386, 15294, 28031, 8211, 16070, 39184, 1711, 7111, 14183, 37495, 22653, 5551, 25513, 3615, 1357, 116, 14407, 3224, 2288, 4724, 9778, 25513, 9566, 32748, 2304, 45865, 39627, 15730, 25124, 28820, 4724, 1829, 9381, 13546, 8608, 1829, 7649, 41779, 3794, 4724, 1829, 9381, 13546, 16490, 25513, 9566, 9307, 20666, 1863, 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"end": 2222.35, "word": " بشكل", "probability": 0.93603515625}, {"start": 2222.35, "end": 2223.61, "word": " كبير", "probability": 0.9938151041666666}, {"start": 2223.61, "end": 2224.11, "word": " كثير", "probability": 0.9703776041666666}, {"start": 2224.11, "end": 2225.89, "word": " Hypoplastic", "probability": 0.776580810546875}, {"start": 2225.89, "end": 2226.35, "word": " lymph", "probability": 0.396728515625}, {"start": 2226.35, "end": 2226.97, "word": " vent", "probability": 0.583984375}, {"start": 2226.97, "end": 2227.57, "word": " heart", "probability": 0.515625}], "temperature": 1.0}, {"id": 83, "seek": 225611, "start": 2227.97, "end": 2256.11, "text": "يعني فيه مشكلة إنه تكون الـ left ventricle بيصير ضعيف في حالة بيسموها aseptal defect عبارة عن الفتحة بين الأذينين اليمين واليسار اللي هي بتكون أصلاً مهمة في حالة الـ في المرحلة الجنينية المرحلة الجنينية يعني أحنا ماعناش lungs تاخد هو", "tokens": [40228, 22653, 8978, 3224, 37893, 28820, 3660, 36145, 3224, 6055, 30544, 2423, 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factors والواحد بيحفظه كمعادلة أو كرقم 1972 فعشرة أو تسعة أو سبعة أو اثنين كل ال factors تبعات الـ Coagulation factors produced by the liver بتم إنتاجها من الكبد", "tokens": [6027, 39184, 3630, 69, 19829, 15844, 2423, 39184, 2423, 39184, 23032, 3555, 3615, 995, 14111, 2423, 39184, 3630, 69, 19829, 31439, 17500, 260, 24976, 39184, 33515, 591, 13672, 1829, 31439, 4724, 1829, 12984, 3555, 2655, 2423, 39184, 33515, 591, 12334, 6771, 4032, 6027, 14407, 24401, 4724, 1829, 5016, 5172, 19913, 3224, 9122, 2304, 3615, 18513, 37977, 34051, 9122, 2288, 4587, 2304, 32952, 6156, 3615, 8592, 25720, 34051, 6055, 3794, 27884, 34051, 8608, 3555, 27884, 34051, 1975, 12984, 1863, 9957, 28242, 2423, 6771, 6055, 3555, 3615, 9307, 2423, 39184, 3066, 559, 2776, 6771, 7126, 538, 264, 15019, 4724, 39237, 11933, 29399, 26108, 11296, 9154, 33251, 44510], "avg_logprob": -0.21344339088448938, "compression_ratio": 1.5564516129032258, "no_speech_prob": 5.960464477539062e-07, "words": [{"start": 2886.64, "end": 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"end": 2902.68, "word": " أو", "probability": 0.98681640625}, {"start": 2902.68, "end": 2903.3, "word": " كرقم", "probability": 0.9884033203125}, {"start": 2903.3, "end": 2905.08, "word": " 1972", "probability": 0.403564453125}, {"start": 2905.08, "end": 2907.44, "word": " فعشرة", "probability": 0.7515869140625}, {"start": 2907.44, "end": 2907.58, "word": " أو", "probability": 0.9658203125}, {"start": 2907.58, "end": 2908.02, "word": " تسعة", "probability": 0.9915364583333334}, {"start": 2908.02, "end": 2908.24, "word": " أو", "probability": 0.98095703125}, {"start": 2908.24, "end": 2908.6, "word": " سبعة", "probability": 0.97216796875}, {"start": 2908.6, "end": 2908.78, "word": " أو", "probability": 0.96240234375}, {"start": 2908.78, "end": 2909.26, "word": " اثنين", "probability": 0.8831787109375}, {"start": 2909.26, "end": 2910.1, "word": " كل", "probability": 0.86376953125}, {"start": 2910.1, "end": 2910.3, "word": " ال", "probability": 0.95556640625}, {"start": 2910.3, "end": 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{"id": 121, "seek": 327504, "start": 3246.8, "end": 3275.04, "text": "يعني مش كل الـ «جين» في كل الخلايا شغالة بنفس الدرجة لأ، حسب مثلا الـ «جين» تبع الـ «هيموجلوبين» بضرب دائما مثال بس في الـ «رد بلد سيلز» بيكون شغال في باقية الخلايا ما له دخله، بقى بتم استخدامه فحتى بالنسبة لـ «هيموجلوبين» الـ «جين» درجة فعليته كم نسخة RNA ناتج عنه", "tokens": [40228, 22653, 37893, 28242, 2423, 39184, 4657, 7435, 9957, 5933, 8978, 28242, 33962, 15040, 25528, 13412, 17082, 6027, 3660, 44945, 36178, 32748, 47341, 3660, 5296, 10721, 12399, 11331, 35457, 50113, 15040, 2423, 39184, 4657, 7435, 9957, 5933, 6055, 3555, 3615, 2423, 39184, 4657, 3224, 32640, 29245, 1211, 37746, 9957, 5933, 4724, 11242, 25513, 11778, 16373, 15042, 50113, 6027, 4724, 3794, 8978, 2423, 39184, 4657, 2288, 3215, 4724, 1211, 3215, 8608, 26895, 11622, 5933, 4724, 1829, 30544, 13412, 17082, 6027, 8978, 4724, 995, 4587, 10632, 33962, 15040, 25528, 19446, 46740, 11778, 9778, 43761, 12399, 4724, 4587, 7578, 4724, 39237, 44713, 9778, 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"end": 3299.95, "word": " إيش", "probability": 0.8229166666666666}, {"start": 3299.95, "end": 3300.65, "word": " الجينات", "probability": 0.960205078125}, {"start": 3300.65, "end": 3301.65, "word": " المسؤولة", "probability": 0.9271484375}, {"start": 3301.65, "end": 3302.57, "word": " بنشاطة", "probability": 0.88427734375}, {"start": 3302.57, "end": 3302.73, "word": " عن", "probability": 0.99609375}, {"start": 3302.73, "end": 3303.13, "word": " حدوث", "probability": 0.99365234375}, {"start": 3303.13, "end": 3303.47, "word": " مرض", "probability": 0.992431640625}, {"start": 3303.47, "end": 3303.93, "word": " معين", "probability": 0.993896484375}], "temperature": 1.0}, {"id": 123, "seek": 332405, "start": 3304.31, "end": 3324.05, "text": "يعني هذه الـ الـ يعني الـ gene expression بتكون إنه إحنا بندرس بشكل عام درجة نشاط الجينات كلها بمين اللي زايدات ومين اللي ناقصات", "tokens": [40228, 22653, 29538, 2423, 39184, 2423, 39184, 37495, 22653, 2423, 39184, 12186, 6114, 39894, 30544, 36145, 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/_M5_4TMqxTY_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/_M5_4TMqxTY_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..10cdaa4f4d5f5ebf0c56846e050693b477ecf641
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/_M5_4TMqxTY_raw.srt
@@ -0,0 +1,2217 @@
+1
+00:00:00,000 --> 00:00:09,380
+الأن اليوم راح نتكلم عن الموضوع
+
+2
+00:00:09,380 --> 00:00:13,680
+الثالث من أنواع أو النوع الثالث Third type of
+
+3
+00:00:13,680 --> 00:00:19,400
+genetic diseases أو genetic inheritance اللي هو
+
+4
+00:00:19,400 --> 00:00:24,340
+الـComplex inheritance of common multifactorial
+
+5
+00:00:24,340 --> 00:00:29,100
+disorders القصد في الموضوع هذا أنه أحنا أصبحنا
+
+6
+00:00:29,100 --> 00:00:34,460
+أخدينالنوعين اللي هو الـ Chromosomal Diseases أو
+
+7
+00:00:34,460 --> 00:00:39,560
+Subchromosomal Diseases وهذه النوع النوع الثاني من
+
+8
+00:00:39,560 --> 00:00:43,280
+الـ Dalian أو الـ Single Genetic Disorders والآن
+
+9
+00:00:43,280 --> 00:00:46,240
+المجموعة الثالث اللي هي الأشياء بتكون
+
+10
+00:00:46,240 --> 00:00:49,920
+Multifactorial
+
+11
+00:00:49,920 --> 00:00:54,220
+الجدول
+
+12
+00:00:54,220 --> 00:01:03,380
+الأول يعنيبفرجنا أهمية أو نسبة الأمراض اللي فيها
+
+13
+00:01:03,380 --> 00:01:09,380
+جانب وراثي على ثلاث مراحل في حياة الإنسان أو في
+
+14
+00:01:09,380 --> 00:01:20,340
+حياة البشرلما نعمل دراسات على الحدوثة
+
+15
+00:01:20,340 --> 00:01:25,360
+فبالنسبة
+
+16
+00:01:25,360 --> 00:01:29,580
+للنوع الأول الـ Chromosomal Mutations أو
+
+17
+00:01:29,580 --> 00:01:34,120
+Chromosomal Diseases لما بنشوف الـ Incidence at
+
+18
+00:01:34,120 --> 00:01:41,830
+Birth لكل ألف ولادة نلاقيها تقريباً ستةوالـ
+
+19
+00:01:41,830 --> 00:01:47,470
+بالنسبة لـ الـ due to single gene mutation بقدر
+
+20
+00:01:47,470 --> 00:01:51,210
+بيكونوا حوالي عشرة و الـ multifactorial
+
+21
+00:01:51,210 --> 00:01:58,530
+inheritance بقدر حوالي خمسين فهذه يعني النسب
+
+22
+00:01:58,530 --> 00:02:02,790
+المتوقعة بس يعني الملاحظ بالكاميرا واحد يعني نقارن
+
+23
+00:02:02,790 --> 00:02:12,450
+بعدين اللي هي أنهعلى عمر الـ25 سنة الـ…
+
+24
+00:02:12,450 --> 00:02:16,650
+الـChromosomal mutations الـPrevalence يعني
+
+25
+00:02:16,650 --> 00:02:22,950
+بالنسبة لحدوثه أو تواجده بيتلاقيها صارت أقل، يعني
+
+26
+00:02:22,950 --> 00:02:26,990
+فيه احتمالية كبيرة أنه يكون الـChromosomal
+
+27
+00:02:26,990 --> 00:02:30,810
+mutation أن المريض ما أو الإنسان ما يطول لعمر
+
+28
+00:02:30,810 --> 00:02:37,380
+الـ25 سنةوالـ Single Gene Mutation برضه بنزله
+
+29
+00:02:37,380 --> 00:02:41,980
+وبالنسبة للـ Multifactorial Inheritance برضه
+
+30
+00:02:41,980 --> 00:02:46,740
+نسبتها عالية لما يكون الواحد يأخذ الـ Population
+
+31
+00:02:46,740 --> 00:02:54,700
+بشكل كامل الأرقام حتى بتختلف بشكل أكبر الـ Single
+
+32
+00:02:54,700 --> 00:03:00,100
+Mutation أو الـ Chromosomal Mutations عددها قليل
+
+33
+00:03:01,270 --> 00:03:06,070
+وكذلك الـ Single-Gene المندليان بيبينوا أكثر
+
+34
+00:03:06,070 --> 00:03:10,410
+بيصيروا عشرين تظهر أشياء أكتر على عمره أكبر شوية
+
+35
+00:03:10,410 --> 00:03:15,870
+وبعدين الـ Multifactorial بيصير إن انفجار فيهم
+
+36
+00:03:15,870 --> 00:03:21,170
+بتضاعف حوالي أتناشر مرة في الـ General Population
+
+37
+00:03:21,170 --> 00:03:26,090
+لحوالي 600 مرض With Multifactorial Inheritance
+
+38
+00:03:26,090 --> 00:03:32,960
+فصراحة أكبر مجموعة هي هذه المجموعةدورها بيبين أكثر
+
+39
+00:03:32,960 --> 00:03:43,660
+مع تقدم العمر أو زيادة العمر وهذه القضية بتفرضين
+
+40
+00:03:43,660 --> 00:03:49,200
+أهمية العوامل المشتركة بين البيئة وبين الوراثة
+
+41
+00:03:49,200 --> 00:03:56,930
+سنتين، كيف انهم بتدخلوا في قضيةفي قضايا تسبب
+
+42
+00:03:56,930 --> 00:04:02,450
+بالأمراض أكتر بكثير من single gene أو chromosomal
+
+43
+00:04:02,450 --> 00:04:10,910
+mutations الملاحظ على إن كثير من الظواهر الصحية
+
+44
+00:04:10,910 --> 00:04:15,710
+والطبية وغيرها في جسم الإنسان وفي حياة البشر بتكون
+
+45
+00:04:15,710 --> 00:04:19,470
+تتبع المنحنة الطبيعية اللي هو الـNormal
+
+46
+00:04:19,470 --> 00:04:23,630
+Distributionالـ Normal Distribution له أكثر من
+
+47
+00:04:23,630 --> 00:04:30,990
+طريقة يعني هيك بقولك زي شكل الجرس بيكون له شكل
+
+48
+00:04:30,990 --> 00:04:38,960
+معين الواحد بياخدها ضمن معايير معينةاللي هو يعني
+
+49
+00:04:38,960 --> 00:04:46,500
+أحيانًا يُذكر أنه الـ «distribution» أو التوزيع أو
+
+50
+00:04:46,500 --> 00:04:53,920
+الـ أو الـ يعني التوزيع الطبيعي اللي بيكون فيه الـ
+
+51
+00:04:53,920 --> 00:04:57,320
+«main» والـ «median» والـ «meridian» كلها نفس
+
+52
+00:04:57,320 --> 00:05:05,710
+القيمة يعني المتوسط الحسابيوأكثر قراءة تحدث
+
+53
+00:05:05,710 --> 00:05:09,850
+والقراءة
+
+54
+00:05:09,850 --> 00:05:14,870
+اللي بالنص تمامًا إذا رتبناهم كلها بتكون قيم
+
+55
+00:05:14,870 --> 00:05:20,690
+متساوية مثلًا زي هنا مثال على الـ Systolic Blood
+
+56
+00:05:20,690 --> 00:05:27,340
+Pressure اللي هو ضغط القلب، ضغط الدم الإنقباضيوأنا
+
+57
+00:05:27,340 --> 00:05:33,100
+بأخد
+
+58
+00:05:33,100 --> 00:05:37,340
+قراءات من عدد كبير من البشر وألاقيهم ماشيين بهذه
+
+59
+00:05:37,340 --> 00:05:44,200
+الطريقة الـ mean بالنصف الـ one standard deviation
+
+60
+00:05:44,200 --> 00:05:49,660
+يعني انحراف معياري واحد one standard deviation
+
+61
+00:05:49,660 --> 00:05:59,790
+بغطي تقريبًا 67% من ال populationيعني تقريبًا ثلثي
+
+62
+00:05:59,790 --> 00:06:05,910
+الفرقات بتكون ضمن حوالين الـMean بـOne Standard
+
+63
+00:06:05,910 --> 00:06:09,550
+Deviation لما نحط Two Standard Deviations بنوصل
+
+64
+00:06:09,550 --> 00:06:18,250
+حوالي 95% من الـCalculation يعني هذه قيم وأشياء
+
+65
+00:06:18,250 --> 00:06:23,390
+كثيرة من ظواهر الحياة الطبيعية بتلاقيها بتتبع هذا
+
+66
+00:06:23,390 --> 00:06:27,930
+المنحنةوبتكون ضمن هذا النظام وبتكون إنه إذا الواحد
+
+67
+00:06:27,930 --> 00:06:31,950
+بعرف الـMean والـStandard Deviation إن هذولا
+
+68
+00:06:31,950 --> 00:06:40,090
+الرقمين بتلاقي بيستطيع أنه يعني يتخيل أو يكوّم
+
+69
+00:06:40,090 --> 00:06:45,450
+فكرة أو يرسم صورة عن كيف القراءات راح تكون
+
+70
+00:06:45,450 --> 00:06:48,530
+فبالنسبة
+
+71
+00:06:48,530 --> 00:06:50,830
+للأمراض
+
+72
+00:06:53,330 --> 00:06:59,470
+اللي هي Multifactorial اللي بتنشأ بسبب تداخلات من
+
+73
+00:06:59,470 --> 00:07:05,770
+جينات عددها كبير الفكرة اللي بدل واحد ياخدها
+
+74
+00:07:05,770 --> 00:07:12,730
+الأولى إنه، يعني أنا بقول هي من جانبين أو هي من
+
+75
+00:07:12,730 --> 00:07:20,970
+مستويين أحنا كنا، يعني طبعاً جزء من الموضوع إنه في
+
+76
+00:07:20,970 --> 00:07:30,040
+مشاركة لعدد كبيرمن الجينات وفي اختلاف في قوة تأثير
+
+77
+00:07:30,040 --> 00:07:36,620
+البدائل الـ Alleles الممكنة لكل جين وبالتالي
+
+78
+00:07:36,620 --> 00:07:47,540
+بيشتركوا في قضية تسبب بالمرض فمثلًا هنا مثال على
+
+79
+00:07:47,540 --> 00:07:56,210
+موقع افتراضي، جين افتراضيلما ندرس الأخوين، نلاقي
+
+80
+00:07:56,210 --> 00:08:02,130
+أنه لمجموعة
+
+81
+00:08:02,130 --> 00:08:06,830
+الجينات
+
+82
+00:08:06,830 --> 00:08:13,810
+نلاقي أنه في تفاوت في البدائل الأليل الممكنة أن
+
+83
+00:08:13,810 --> 00:08:18,210
+بعضها بيكون أقوى في التسبب أو في العلاقة مع مرض
+
+84
+00:08:18,210 --> 00:08:25,690
+معين وبعضها بيكون أقلبعضها بيحمي وبعضها بيسبب وإنه
+
+85
+00:08:25,690 --> 00:08:33,470
+عدد كبير يشترك في التسبب مثال على ذلك الـ Rabo
+
+86
+00:08:33,470 --> 00:08:41,550
+اللي هو قضية التحسس الهوائي وتضيق القصابات بشكل
+
+87
+00:08:41,550 --> 00:08:50,100
+متقطع وكذا نجد إنه بتكونإذا الواحد درس كام جين
+
+88
+00:08:50,100 --> 00:08:55,980
+بيشترك في التسبب بتلاقي حوالي ما يقارب الخمسين جين
+
+89
+00:08:55,980 --> 00:09:03,340
+وبكونوا يعني قوتهم في التسبب كل واحد اللي هو
+
+90
+00:09:03,340 --> 00:09:08,240
+بيمفرد وضعيف يعني وفي تفاوت في الضعف هذا بس لما
+
+91
+00:09:08,240 --> 00:09:13,620
+يكون العدد كبير بشكل معين بتلاقي الرابط بيكون
+
+92
+00:09:13,620 --> 00:09:20,130
+أشويع أو أقوى وكدهفهذه يعني ملاحظة اللي هي إنه عدد
+
+93
+00:09:20,130 --> 00:09:26,650
+كبير من الجينات تشترك الظواهر الثانية أحنا كنا
+
+94
+00:09:26,650 --> 00:09:31,470
+أشارنا إلها من قبل في قضية العلم التخلق أو الـ
+
+95
+00:09:31,470 --> 00:09:38,390
+Epigenetics اللي هي إنه يعني مش فقط التغير
+
+96
+00:09:38,390 --> 00:09:45,230
+البنيوي، التغيرهيكل إلى الجين من ناحية أنه قليل
+
+97
+00:09:45,230 --> 00:09:50,310
+بشكل معين يعني ممكن يعطينا بروتين مختلف مش بس هذا
+
+98
+00:09:50,310 --> 00:09:55,470
+الاختلاف الاختلاف الثاني هي في درجة نشاط الجينات
+
+99
+00:09:55,470 --> 00:10:03,730
+يعني ممكن شخصين نفس الجين، نفس القليل بس لما يكون
+
+100
+00:10:03,730 --> 00:10:10,530
+نشاط شديد بتلاقي مثل المرض موجود نشاط قليل، المرض
+
+101
+00:10:10,530 --> 00:10:16,610
+مش موجودبتكون برضه بهذه الطريقة فقضية التفاوت في
+
+102
+00:10:16,610 --> 00:10:22,070
+نشاط الجينات هذا اللي هو علم الـ Epigenetics وإيه
+
+103
+00:10:22,070 --> 00:10:27,230
+اللي دخل لاحظنا في قضية الـ methylation للـ DNA
+
+104
+00:10:27,230 --> 00:10:32,330
+الـ methylation للـ Histones الـ microRNAs البصمة
+
+105
+00:10:32,330 --> 00:10:35,710
+الوراثية اللي هي الـ Parental Imprinting هذه
+
+106
+00:10:35,710 --> 00:10:38,450
+الأشياء اللي ما فهمناهوش أو ما كانوا للأغلب مش
+
+107
+00:10:38,450 --> 00:10:45,260
+فاهموا، هدولة كلها أشكال فيبتسوي اختلاف في نشاط
+
+108
+00:10:45,260 --> 00:10:54,760
+الجين وبالتالي، يعني هذه برضه لدقل ولها تأثير
+
+109
+00:10:54,760 --> 00:11:02,620
+في قضية حدوث الأمراض لو جينة ناخد، وبصراحة
+
+110
+00:11:02,620 --> 00:11:11,720
+المحاضرة عندكميعني حاطين أمثلة كثيرة بدناش ندخل
+
+111
+00:11:11,720 --> 00:11:20,620
+فيها يعني ما بدي مش هدفنا إنه نطلعكم خبراء بالمجمل
+
+112
+00:11:20,620 --> 00:11:31,620
+الموضوع بشكل تفصيلي عن كام نسبة الحدوث مرض معين في
+
+113
+00:11:31,620 --> 00:11:35,220
+إنسان إذا كان حد من أقاربه عنده نفس المشكلة
+
+114
+00:11:37,960 --> 00:11:45,560
+هذه جدول من أحد المراجع بيمثل
+
+115
+00:11:45,560 --> 00:11:50,560
+الـ Relative أو الـ Risk Ratio اللي هي الإشارة هذه
+
+116
+00:11:50,560 --> 00:11:58,620
+الـ RS أظن هي معناته أو رؤس الـ Risk Ratio هي إذا
+
+117
+00:11:58,620 --> 00:12:05,130
+كان إنسانعنده من أقاربه،
+
+118
+00:12:05,130 --> 00:12:13,410
+يعني من أخوانه
+
+119
+00:12:13,410 --> 00:12:22,250
+و أخواته مباشرة لشخص مصاب بمرض معين كم مضاعفات
+
+120
+00:12:22,250 --> 00:12:29,950
+احتمالية أن يصير عنده هذا المرض مقارنة بغيرهفمثلًا
+
+121
+00:12:29,950 --> 00:12:34,610
+الأمراض النفسية الـ Schizophrenia أو انفسام
+
+122
+00:12:34,610 --> 00:12:42,650
+الشخصية إذا أخ أو أخت مصاب بهذا المرض لشخص مصاب
+
+123
+00:12:42,650 --> 00:12:48,590
+أخوانه و أخواته احتمالية إصابتهم فيها أتناشر ضعف
+
+124
+00:12:48,590 --> 00:12:53,690
+من لو ما كانش فيه قرابة أو ما كانش فيه مرض ضمن
+
+125
+00:12:53,690 --> 00:12:58,390
+العائلة الـ Autism التوحدمن الأمراض النفسية أو
+
+126
+00:12:58,390 --> 00:13:04,150
+السلوكية برضه 150 مرة الـ Manic Depressive Bipolar
+
+127
+00:13:04,150 --> 00:13:09,930
+Disorder برضه من الأمراض النفسية سبع مرات السكر
+
+128
+00:13:09,930 --> 00:13:14,270
+النوع الأول وهو يعتبر يعني مش النوع الوراثة القوى
+
+129
+00:13:14,270 --> 00:13:18,750
+كثير كثير نسبة الحدوث، ورح نشوف إنها دراسة ثانية
+
+130
+00:13:18,750 --> 00:13:22,190
+بالنسبة
+
+131
+00:13:22,190 --> 00:13:29,070
+لما الإنسان يكون أحدأقارب أو أحد أشقائه أو شقيقاته
+
+132
+00:13:29,070 --> 00:13:34,090
+مصاب خمسة وثلاثين مرة مرض Crohn's Disease اللي هو
+
+133
+00:13:34,090 --> 00:13:37,390
+الـ Inflammatory Bowel Disease من أمراض المناعة
+
+134
+00:13:37,390 --> 00:13:42,690
+الباتية على الجهاز الهضمي خمسة وعشرين مرة الـ
+
+135
+00:13:42,690 --> 00:13:46,490
+Multiple Sclerosis أو التصلب اللويحي أربعة وعشرين
+
+136
+00:13:46,490 --> 00:13:52,990
+مرة يعني الملاحظ في كل هذه الأمراض وراح نأخد أمثلة
+
+137
+00:13:52,990 --> 00:13:59,170
+كثيرةأنه مجرد حدوث المرض
+
+138
+00:13:59,170 --> 00:14:04,470
+أو تواجده في العائلة في أحد الأشقاء برفع نسبة
+
+139
+00:14:04,470 --> 00:14:10,710
+احتمالية حدوثه في الأشقاء الآخرين بنسبة عالية جداً
+
+140
+00:14:10,710 --> 00:14:16,710
+وهذا تأثير على دور
+
+141
+00:14:16,710 --> 00:14:21,770
+الوراثة في قضية التسبب بمرض معين
+
+142
+00:14:24,310 --> 00:14:32,110
+فكثير من الأمراض لها دور بس قد يكون قائل يعني اللي
+
+143
+00:14:32,110 --> 00:14:39,870
+هي أن الأشقاء عادة بعيشوا مع بعض وبالتالي بيئتهم
+
+144
+00:14:39,870 --> 00:14:45,490
+متشابهة فقد يكون هذه النسب وهذه الزيادة قد تكون
+
+145
+00:14:45,490 --> 00:14:53,050
+بسبب نمط حياة معين بسبب بيئة معينةبتشاركوا فيها
+
+146
+00:14:53,050 --> 00:14:57,430
+وبالتالي زادت النسبة بسبب المشاركة في البيئة وليس
+
+147
+00:14:57,430 --> 00:15:03,030
+بسبب مشاركة في الجينات يعني الكثير من الظواهر
+
+148
+00:15:03,030 --> 00:15:09,430
+العامة يعني مثلا هنا دراسة عن نسبة الدهول
+
+149
+00:15:09,430 --> 00:15:15,370
+والكلسترول بين الأمهات والأطفال أو الأبناء
+
+150
+00:15:17,820 --> 00:15:23,480
+فيعني عددهم يعني وأنا الأمات بين عمر الـ 30 والـ
+
+151
+00:15:23,480 --> 00:15:30,540
+39 والأبناء بين عمر الأربع سنوات والتسع سنوات وشوف
+
+152
+00:15:30,540 --> 00:15:37,660
+العلاقة بينهم تقريبًا يعني نقدرنا نرسم الخط لـ
+
+153
+00:15:37,660 --> 00:15:45,850
+يعني ما يمثل المجمل العلاقات أنه كل ما كانتالأم
+
+154
+00:15:45,850 --> 00:15:49,730
+الـ «كوليسترول» عندها أعلى «الإبن» برضه عنده الـ
+
+155
+00:15:49,730 --> 00:15:55,030
+«كوليسترول» أعلى فهذه قضية يعني طبعاً في تفاوت
+
+156
+00:15:55,030 --> 00:16:02,730
+شديد بالنقاط حوالين الخط هذا بس واضح إنه الواحد
+
+157
+00:16:02,730 --> 00:16:10,390
+بيشوف إنه بشكل عام كل ما كان القراءة أوطة للأم
+
+158
+00:16:10,390 --> 00:16:16,270
+بتكون للطفل أو للإبن واطيةوكل ما كانت أعلى بتكون
+
+159
+00:16:16,270 --> 00:16:21,370
+للأبن أعلى فأحياناً في علاقات مثل بياتها هذا الشكل
+
+160
+00:16:21,370 --> 00:16:29,490
+اللي بنشوفها وبالتالي بنصير يعني نقيم تأثير سواء
+
+161
+00:16:29,490 --> 00:16:35,970
+بين قوسين الوراثة والبيئة
+
+162
+00:16:37,290 --> 00:16:49,110
+درجة حدوث اللي هو في كام عدد المصابين
+
+163
+00:16:49,110 --> 00:16:56,430
+في العائلة ناخد هنا مثلًا مثال اللي بيسموها الشفاة
+
+164
+00:16:56,430 --> 00:17:03,770
+الأرنبية الـ Cleft Lip and Palate اللي هي يعني عيب
+
+165
+00:17:03,770 --> 00:17:10,840
+خلقي بيكون فيه شق فيهالشفاء العليا بحوالي من الفم
+
+166
+00:17:10,840 --> 00:17:18,560
+وبكون منظر معروف ومشهور فهذه الظاهرة إذا أخدنا
+
+167
+00:17:18,560 --> 00:17:31,340
+دراسة لو كان أخدنا إن إنسان له والد أو والدة واحدة
+
+168
+00:17:31,340 --> 00:17:36,330
+فقط في المصابة، ماشي؟number of affected parents،
+
+169
+00:17:36,330 --> 00:17:41,070
+يا إما صفر، يا إما واحد، يا إما أحيانًا بيحدث إنه
+
+170
+00:17:41,070 --> 00:17:46,770
+أثنين بيتزوجوا عندهم نفس الظاهرة، فإذا كان الأباء
+
+171
+00:17:46,770 --> 00:17:54,330
+بهذا الترتيب، نجد أنه في أحد هذه الدراسات، وجيت
+
+172
+00:17:54,330 --> 00:18:01,170
+أنا أشوف إنه مافيش حد كام عدد اللي بيكونوا مصابين
+
+173
+00:18:01,170 --> 00:18:05,900
+في مثل هذهيعني إنه إذا كانت العائلة ما عندهاش ولا
+
+174
+00:18:05,900 --> 00:18:16,440
+حدا مصاب بشكل مسبق في حالة إنه
+
+175
+00:18:16,440 --> 00:18:21,120
+مافيش ولا ولي أمر أو أب و أم و والدين مصاب
+
+176
+00:18:21,120 --> 00:18:27,640
+احتمالية الإصابة 0.1 يعني اللي هي الـRisk Ratio
+
+177
+00:18:27,640 --> 00:18:34,060
+تلاقيها منخفضة نسبياً جداًلما يكون أحدهما يصبح
+
+178
+00:18:34,060 --> 00:18:39,700
+ثلاثة يعني هذه الضعفة تلاتين مرة ولما يكون الأثنين
+
+179
+00:18:39,700 --> 00:18:44,760
+المضاعفة ثلاثمائة مرة عن الأصل يعني أربعة وثلاثين
+
+180
+00:18:44,760 --> 00:18:53,400
+ضعف عن الـ تلاتمية وأربعين ضعف عن الأولى يعني أو
+
+181
+00:18:53,400 --> 00:18:58,720
+عشر أضعاف عن لما يكون one parent عنده المشكلة إذا
+
+182
+00:18:58,720 --> 00:19:03,300
+كان في one sibling عنده مشكلةالأرقام أعلى، إذا
+
+183
+00:19:03,300 --> 00:19:09,600
+أكثر حتى في العائلة الممتدة بتلاقي النسب لسه كمان
+
+184
+00:19:09,600 --> 00:19:14,880
+أعلى، إذا two siblings إنها أعلى النسب، لما يكون
+
+185
+00:19:14,880 --> 00:19:21,860
+بالذات الوالدين مصابين واخوين مصابين، نسبة الإصابة
+
+186
+00:19:21,860 --> 00:19:30,100
+تقترب من الـ 50% المتوقعة في الحالة
+
+187
+00:19:30,100 --> 00:19:37,700
+هذهفبلاحظ درجة والتواجدها كل ما زاد العدد والتواجد
+
+188
+00:19:37,700 --> 00:19:47,580
+أكثر بتكون نسب الإصابة أعلى فيها فهي مثال على درجة
+
+189
+00:19:47,580 --> 00:19:59,110
+تداخل الـ Penetration أو ظهور الصفة الوراثيةودرجة
+
+190
+00:19:59,110 --> 00:20:03,610
+تواجدها إنه إذا حدثت إنه الحالة موجودة عند
+
+191
+00:20:03,610 --> 00:20:08,930
+الوالدين الأثنين النسب بتكون أعلى بكثير من لو
+
+192
+00:20:08,930 --> 00:20:15,090
+مافيش أي حد عنده المشكلة هذه فهو هنا مثال على الـ
+
+193
+00:20:15,090 --> 00:20:22,410
+Cleft lip وcleft palate وكيف إنها صفة إليها دخل
+
+194
+00:20:22,410 --> 00:20:30,140
+بالوراثةويعني إنه الوراثة
+
+195
+00:20:30,140 --> 00:20:36,340
+بتلعب دور كبير فيها وإن كان يعني ممكن واحد يتكلم
+
+196
+00:20:36,340 --> 00:20:42,120
+عن أشياء أخرى لما
+
+197
+00:20:42,120 --> 00:20:51,190
+نكون الواحد يشوف بالنسبة لصفة وراثية أخرىويشوف لما
+
+198
+00:20:51,190 --> 00:20:58,110
+حكينا مثل قبل شوية عن الصفات
+
+199
+00:20:58,110 --> 00:21:07,050
+الوراثية برجع الواحد يقول سؤال اللي هو مين اللي هم
+
+200
+00:21:07,050 --> 00:21:12,550
+بيكونوا نتيجة البيئة ومين اللي بيكون نتيجة المادة
+
+201
+00:21:12,550 --> 00:21:20,710
+الوراثية أو الجيناتدايماً الـ «زيجوتك توينت»
+
+202
+00:21:20,710 --> 00:21:25,810
+«Mono» أو «Di-zygotic twins» هما اللي بيعطونا كمان
+
+203
+00:21:25,810 --> 00:21:31,190
+فكرة وإن كان فيه دراسة بعدين راح ناخدها هنا كمثال
+
+204
+00:21:31,190 --> 00:21:42,170
+محاولة تفريق أهمية البيئة عن أهمية الوراثة الفكرة
+
+205
+00:21:42,170 --> 00:21:48,580
+في الموضوع أنهكثير من الظواهر لما نأتي نأخذ
+
+206
+00:21:48,580 --> 00:21:57,560
+identical twins زي المثال الأول هنا بتلاقي المادة
+
+207
+00:21:57,560 --> 00:22:05,300
+الوراثية متطابقة ولما نأخذ dizygotic twins يعني
+
+208
+00:22:05,300 --> 00:22:10,320
+هنا زي اللي بالنص بتلاقي فيه تفاوت، فيه اختلافات
+
+209
+00:22:10,320 --> 00:22:14,340
+الـ Monozygotic twins اللي على اليمين وعلى اليسار
+
+210
+00:22:14,910 --> 00:22:25,570
+اللي هما بيكونوا يعني في الحالات هذه بيكونوا
+
+211
+00:22:25,570 --> 00:22:30,970
+يا أما ذكورا أو إناثا متشابهين فبيكونوا من نفس
+
+212
+00:22:30,970 --> 00:22:37,690
+الجنس إذا أحنا بنتفرج على كيف توزيع المادة
+
+213
+00:22:37,690 --> 00:22:43,710
+الوراثية بتلاقي أنه في تطابق شبه كامل بين الطرفين
+
+214
+00:22:44,090 --> 00:22:50,350
+بينما لما يكون بيكونوا
+
+215
+00:22:50,350 --> 00:22:56,830
+يعني شخصين مختلفين يعني المادة الوراثية تبعاتهم
+
+216
+00:22:56,830 --> 00:23:03,630
+مختلفة نتيجة أنه مثلا بويضتين تلقح في حيوانين
+
+217
+00:23:03,630 --> 00:23:10,320
+منويين في نفس المرة مثلا أنه كانت هيكفبينتج عنه
+
+218
+00:23:10,320 --> 00:23:16,360
+إنه كأن هذولة أخوين في بطنين مختلفين فتلاقي فيه
+
+219
+00:23:16,360 --> 00:23:21,920
+فروقات بينهم فمثل هذه الظاهرة تستفاد منها في قضية
+
+220
+00:23:21,920 --> 00:23:30,360
+محاولة دراسة تأثير البيئة من تأثير المادة الوراثية
+
+221
+00:23:33,160 --> 00:23:39,940
+فيه معامل أو ظاهرة الـ Concordance الـ Concordance
+
+222
+00:23:39,940 --> 00:23:46,540
+يعني إذا كان إنسان عنده مرض ضمن أي مجموعة
+
+223
+00:23:46,540 --> 00:23:49,000
+«مونوزايجوتيك» أو «دايزايجوتيك» Twin
+
+224
+00:23:49,000 --> 00:23:49,660
+«مونوزايجوتيك» أو «دايزايجوتيك» Twin
+
+225
+00:23:49,660 --> 00:23:50,180
+«مونوزايجوتيك» أو «دايزايجوتيك» Twin
+
+226
+00:23:50,180 --> 00:23:51,500
+«مونوزايجوتيك» أو «دايزايجوتيك» Twin
+
+227
+00:23:51,500 --> 00:23:53,240
+«مونوزايجوتيك» أو «دايزايجوتيك» Twin
+
+228
+00:23:53,240 --> 00:23:56,720
+«مونوزايجوتيك» أو «دايزايجوتيك» Twin
+
+229
+00:23:56,720 --> 00:24:02,040
+«مونوزايجوتيك» أو «دايزايجوتيك» Twin «مونوزايجوت
+
+230
+00:24:02,560 --> 00:24:09,300
+الـ Dizygotic Twins اللي هما يعني كأنه أخوين برضه
+
+231
+00:24:09,300 --> 00:24:14,680
+فيه نسب هي أقل بس بيظل أكبر بكثير من الـ General
+
+232
+00:24:14,680 --> 00:24:22,340
+Population يعني اللي زي ما لاحظنا من قبل في يعني
+
+233
+00:24:22,340 --> 00:24:26,520
+هاي بعتبرها مش كاملة كثير يعني في شيء أنا دائما
+
+234
+00:24:26,520 --> 00:24:32,890
+بعرفه بحفظه وبقول للطلابلو أخذنا السكر النوع الأول
+
+235
+00:24:32,890 --> 00:24:38,070
+اللي هو سكر الأطفال اللي بيكون فيه تحطيم للـ Beta
+
+236
+00:24:38,070 --> 00:24:42,620
+Cell البنك الرئاسيوبيكون فيش إنسولين وبيصير عندنا
+
+237
+00:24:42,620 --> 00:24:47,820
+مرض السكر النوع الأول أو المؤتمد على الإنسولين،
+
+238
+00:24:47,820 --> 00:24:52,240
+insulin-dependent diabetes mellitus نسبة الـ
+
+239
+00:24:52,240 --> 00:24:56,440
+concordance في الـ monozygotic twins حوالي خمسين
+
+240
+00:24:56,440 --> 00:25:01,040
+بالمية، أنا هيك بذكر الرقم كانوا يعطونا يعنى،
+
+241
+00:25:01,040 --> 00:25:07,340
+بينما لو type 2 diabetes، بيكون نسبة الـ
+
+242
+00:25:07,340 --> 00:25:14,710
+concordance مية بالمية، يعنيإذا كان أخوه أو أخته
+
+243
+00:25:14,710 --> 00:25:20,250
+إذا كانت إينات أو أخوها أو أخوه إذا كان ذكور واحد
+
+244
+00:25:20,250 --> 00:25:23,430
+منهم مصيب بالـ Type 2 Diabetes نسبة الـ
+
+245
+00:25:23,430 --> 00:25:28,110
+Concordance 100% فهي يعني، أنا بعتبرها كانت
+
+246
+00:25:28,110 --> 00:25:33,330
+المفروض تكون أقوى ويمؤشر على إن الـGenetics تلعب
+
+247
+00:25:33,330 --> 00:25:38,810
+دور Multifactorial Disorder فلو
+
+248
+00:25:38,810 --> 00:25:44,800
+نيجي ناخدالقراءات في مناهية دراسة مش أرقام للحفظ
+
+249
+00:25:44,800 --> 00:25:52,360
+بمعنى الحفظ بقدر ما أنه فيه تفاوت وفيه نسب اللي
+
+250
+00:25:52,360 --> 00:25:58,740
+بدنا نلاحظها بس الأهم شيء أنه الـ الـ الـ الـ الـ
+
+251
+00:25:58,740 --> 00:26:04,460
+الـ Dizygotic twins إحتمال مؤشر أكثر على تأثير
+
+252
+00:26:04,460 --> 00:26:10,890
+بيئي معين لأنهم الإخوة والـأخوات والعائلة بتعيش في
+
+253
+00:26:10,890 --> 00:26:15,730
+نفس البيئة في الغالب بيتعرضوا لنفس العوامل الـ
+
+254
+00:26:15,730 --> 00:26:21,810
+Monozygotic twins بيكونوا أن الدور الوراثي أقوى
+
+255
+00:26:21,810 --> 00:26:27,250
+لأن المادة الوراثية متطابقة تماماً فبالتالي بنشوف
+
+256
+00:26:27,250 --> 00:26:33,650
+بالنسبة لكثير من الأمراض نسبة حدوثها أكثر في حالة
+
+257
+00:26:33,650 --> 00:26:37,590
+الـ Monozygotic twins في حد عنده سؤال؟
+
+258
+00:26:46,850 --> 00:26:52,890
+فهذه إحدى الدراسات عن الموضوع هذا في دراسة ثانية
+
+259
+00:26:52,890 --> 00:26:56,730
+بشوفها interesting إن الواحد يعني هيك يتطلع عليها
+
+260
+00:26:56,730 --> 00:27:02,530
+ويشوف شو القيام وشو اللي بتي بيحكوا عنها الآن
+
+261
+00:27:02,530 --> 00:27:08,370
+بالنسبة للوزن أحسن مؤشر للوزن عشان قضية اختلاف
+
+262
+00:27:08,370 --> 00:27:12,310
+وتفاوت الطول اللي هو معامل كتلة الجسم اللي هو
+
+263
+00:27:12,310 --> 00:27:19,540
+الـBody Mass Index الـBody Mass Indexهو الوزن
+
+264
+00:27:19,540 --> 00:27:30,840
+بالكيلو على مربع الطول بالمتر يعني إنسان طوله مثلا
+
+265
+00:27:30,840 --> 00:27:38,460
+نقول متر وسبعين صنطي نقسم وزنه ثمانين كيلو ثمانين
+
+266
+00:27:38,460 --> 00:27:42,200
+كيلو بقول بقسم ثمانين على one point seven في one
+
+267
+00:27:42,200 --> 00:27:48,130
+point seven بكون له معادل معينةالجمال المعامل هذا
+
+268
+00:27:48,130 --> 00:27:52,750
+إنه بيعطيك أرقام معروف مثلًا من 19 لـ 25 هذا
+
+269
+00:27:52,750 --> 00:27:58,950
+الإنسان الطبيعي من 25 ل 30 هي فيه زيادة وزن شويه
+
+270
+00:27:58,950 --> 00:28:06,730
+يعني بيقوله overweight شويه من 30 ل 40 سمنة في
+
+271
+00:28:06,730 --> 00:28:11,580
+عنده obesity فوق الأربعينبيقولوا له «morbidly
+
+272
+00:28:11,580 --> 00:28:16,560
+obese» يعني ناصح كثير كثير بشكل سمنة مرضية قاتلة
+
+273
+00:28:16,560 --> 00:28:24,300
+فلما نيجي ناخد في هذه الدراسة حاولوا يفرقوا بين
+
+274
+00:28:24,300 --> 00:28:27,980
+الـ «مونوزيجوتيك» والـ «دايزيجوتيك» Twin types
+
+275
+00:28:27,980 --> 00:28:35,680
+يعني حاولوا يدرسوا فيها ودرسوا الذكور والإناث أو
+
+276
+00:28:35,680 --> 00:28:41,280
+الـ «مايلز» والـ «فيميلز» Men and Womenودرسوا قضية
+
+277
+00:28:41,280 --> 00:28:46,100
+هل عاشوا مع بعض عايشين مع بعض ولّا مفرقين إذا
+
+278
+00:28:46,100 --> 00:28:53,100
+بعيشوا together يعني يعني عايشين في نفس البيت
+
+279
+00:28:53,100 --> 00:28:57,200
+بيأكلوا من نفس الأكل بعيشوا نفس الطريقة بيركبوا
+
+280
+00:28:57,200 --> 00:29:02,560
+نفس السيارة مثلا بيروحوا ماشي قريبين من بعض إذا
+
+281
+00:29:02,560 --> 00:29:08,570
+عايشين apart يعني مربيين في بيئات مختلفةممكن إنه
+
+282
+00:29:08,570 --> 00:29:15,850
+فيه تفاوت في البيئة تكون أكثر فهو راح يعطينا عدد
+
+283
+00:29:15,850 --> 00:29:24,930
+الأزواج من التوائم وأنواعها بالنسبة لكل مرحلة من
+
+284
+00:29:24,930 --> 00:29:34,450
+الدراسة هنا للـ Women وهنا للـ Men وهنا معامل
+
+285
+00:29:34,450 --> 00:29:43,490
+التطابقماشي بالنسبة للـ «مونوزيجوتيك»
+
+286
+00:29:43,490 --> 00:29:53,110
+نلاحظ أنه لما يكونوا «مونوزيجوتيك» ويكونوا يعني
+
+287
+00:29:53,110 --> 00:29:59,310
+الذكور أو الإناث النسب تقريبًا الثلثين أو أكثر، 74
+
+288
+00:29:59,310 --> 00:30:08,430
+%طبعًا الـ 70% لما نتربّب محلين مختلفين وبالنسبة
+
+289
+00:30:08,430 --> 00:30:13,470
+لما نعاشوا مع بعض حتى 75% يعني تقريبًا قريبين جدًا
+
+290
+00:30:13,470 --> 00:30:19,130
+من بعض بينما الـ Disergotic Twins كأخوة وأخوات
+
+291
+00:30:19,130 --> 00:30:25,390
+مختلفين النسب أقل بكثير فبنقدر الواحد يقول وهذه
+
+292
+00:30:25,390 --> 00:30:30,100
+الملاحظة قطمان الجهة الثانية النسب أقل بكثيرإنه
+
+293
+00:30:30,100 --> 00:30:33,360
+يعني الواحد اللي بدي يقوله إنه الوراثة بتلعب دور
+
+294
+00:30:33,360 --> 00:30:39,060
+كبير يعني الدور الأعظم هي لقضية الوراثة إن حجم
+
+295
+00:30:39,060 --> 00:30:43,860
+الواحد أو وزنه بكون بشكل معين وإن فيه نسبة كبيرة
+
+296
+00:30:43,860 --> 00:30:48,500
+من العامل الوراثي لو قارننا الـ Apart عن Together
+
+297
+00:30:48,500 --> 00:30:54,610
+بكل هاتهم بلاقي إنه فيه نسبةلما يكونوا together،
+
+298
+00:30:54,610 --> 00:31:01,390
+نسبة التطابق بتكون أكبر، أقرب لبعض، ماشي، بالذات
+
+299
+00:31:01,390 --> 00:31:06,650
+بالنسبة للذكور أكثر من الإنات، بس كلها تقريبًا،
+
+300
+00:31:06,650 --> 00:31:14,810
+يعني نسب ضئيلة، هنا 4%، هنا صارت 18%، بس هنا 2% و
+
+301
+00:31:14,810 --> 00:31:20,310
+0%، فرق بين إنه عايشين مع بعض أو يعنياللي بنقدر
+
+302
+00:31:20,310 --> 00:31:27,250
+نستنتجه من هذه مثل هيك أرقام أنه نقول إنه الوراثة
+
+303
+00:31:27,250 --> 00:31:32,710
+إلها دخل بس نسبة بسيط الوراثة اللي هو يعني
+
+304
+00:31:32,710 --> 00:31:38,230
+«monozygotic» أو «dizygotic twins» إله همية كبيرة
+
+305
+00:31:38,230 --> 00:31:43,980
+بس البيئة بتلعب دور ثانوي أو بسيطأو يعني هو شيء
+
+306
+00:31:43,980 --> 00:31:51,360
+مؤثر بس درجته بسيطة بالنسبة على عامل قضية الوزن
+
+307
+00:31:51,360 --> 00:31:57,560
+بين الذكور والإينات فهي ملاحظة يعني إنه الوزن نقدر
+
+308
+00:31:57,560 --> 00:32:04,320
+نستنتج بهذه الطريقة إنه نسبة كبيرة من وزن الإنسان
+
+309
+00:32:04,320 --> 00:32:11,900
+يحدده وراثته وفيه جينات بتتدخل في هذا الموضوعوهي
+
+310
+00:32:11,900 --> 00:32:19,620
+اللي بتكون مؤثرة عليه البيئة بحيث إنه كيف كانوا
+
+311
+00:32:19,620 --> 00:32:27,440
+عايشين وشو بيئتهم لها دور بس نسبته قليلة ويعني
+
+312
+00:32:27,440 --> 00:32:34,660
+تأثيره أضعف بكثير من تأثير الوراثةوالوراثة كمان
+
+313
+00:32:34,660 --> 00:32:39,900
+بالـ «مونوزيجوتك توينز» أقوى من الـ «دايزيجوتك
+
+314
+00:32:39,900 --> 00:32:48,220
+توينز» يعني إنها بشكل ملحوظ فهي كلها أمثلة على
+
+315
+00:32:48,220 --> 00:33:01,040
+خواص طبية جسمانية في جوانب مختلفة على قضية التأثير
+
+316
+00:33:01,750 --> 00:33:07,750
+الوراثة والبيئة من خلال عدد كبير من الجينات مافيش
+
+317
+00:33:07,750 --> 00:33:11,570
+جين محدد، it's not dominant أو recessive زي ما كنا
+
+318
+00:33:11,570 --> 00:33:15,910
+نتكلم في الـMandelian Inheritance ولا هي زي
+
+319
+00:33:15,910 --> 00:33:21,970
+الـChromosomal Diseases اللي كنا نحكي عنها الآن
+
+320
+00:33:21,970 --> 00:33:30,830
+حطين أنثى برضه على أهمية الـ
+
+321
+00:33:34,870 --> 00:33:40,390
+الأمراض والحالات اللي بتدخل فيها الـ
+
+322
+00:33:40,390 --> 00:33:44,750
+Multifactorial Inheritance تدخل فيها عداد كبير من
+
+323
+00:33:44,750 --> 00:33:49,970
+الجينات فالـ Cleft Lip وCleft Bullet الـ
+
+324
+00:33:49,970 --> 00:33:54,500
+Congenital Heart Diseasesأو الـ Neuronal Tube
+
+325
+00:33:54,500 --> 00:33:58,840
+Defects أو الـ Spina Bifida أو الـ Anencephaly أو
+
+326
+00:33:58,840 --> 00:34:04,180
+التسكير أو الـ Biliary Stenosis هنا بتتكلموا على
+
+327
+00:34:04,180 --> 00:34:09,660
+Approximate Population Incidence لكل ألف بني آدم
+
+328
+00:34:09,660 --> 00:34:17,840
+كم نسبة الحالات هذه ويعني بالنسبة لمثل هيك أشياء
+
+329
+00:34:17,840 --> 00:34:19,900
+يعني
+
+330
+00:34:22,190 --> 00:34:28,150
+مرة أخرى، عدد كبير من الجينات بتدخل فيها مرات
+
+331
+00:34:28,150 --> 00:34:31,390
+بيقعدوا يبحثوا فيها بالذات إذا في عائلة معينة
+
+332
+00:34:31,390 --> 00:34:35,270
+عندها مشكلة معينة أكثر من غيرها، أقوى من غيرها
+
+333
+00:34:35,270 --> 00:34:43,150
+والشغل الثاني، بدي الواحد يتذكر إنه أحياناً البيئة
+
+334
+00:34:43,150 --> 00:34:48,450
+برضه إلها دخل يعني الـSpina Bifida يعني من الحالات
+
+335
+00:34:48,450 --> 00:34:54,110
+أو الأمراضمثلًا، الأعمل قينة إلها دخل كبير بنقص
+
+336
+00:34:54,110 --> 00:34:58,610
+الـ «فولات» في التخزيه عند الحمل، في الحوامل عشان
+
+337
+00:34:58,610 --> 00:35:02,670
+هيك، إذا بتتم تعويض الـ «فولات» مع الحديد عادةً
+
+338
+00:35:02,670 --> 00:35:07,350
+عشان يعني الدم، نتكلم عنها بس أظن فيه دراسات قوية
+
+339
+00:35:07,350 --> 00:35:13,230
+إن الـ «أسباينة» بيفدأ إذا الواحد بيفرض في المجتمع
+
+340
+00:35:13,230 --> 00:35:20,600
+إنه يعطي تعويض الحواملفي قضية
+
+341
+00:35:20,600 --> 00:35:24,560
+الـ Vital Folate في أحد الفيتامينات اللي بيكون
+
+342
+00:35:24,560 --> 00:35:29,920
+فيها نقص الـ Neuronal Tube Defect بتقل كثير ويكون
+
+343
+00:35:29,920 --> 00:35:36,600
+في اكتمال بناء الجهاز العصبي فهذه أنثى على حالات
+
+344
+00:35:36,600 --> 00:35:46,590
+وبتكون فيها Multifactorial أنا بظن أنه الـالأرقام
+
+345
+00:35:46,590 --> 00:35:59,870
+والتفاصيل بالنسبة لقداش احتمالية حدوث شيء في حالة
+
+346
+00:35:59,870 --> 00:36:06,350
+وجوده في أحد الأقارب أو في أحد الإخوة وقداش نسبته
+
+347
+00:36:06,350 --> 00:36:11,110
+أكثر بتزيد وكذا وكذا، ما بدنا إياها بقدر ما أنه
+
+348
+00:36:11,110 --> 00:36:18,260
+ناخد أن هذه مثالة علىحالة عبارة عن إيها دخل
+
+349
+00:36:18,260 --> 00:36:24,080
+بالنسبة للوراثة بالنسبة للـ Congenital Heart
+
+350
+00:36:24,080 --> 00:36:29,980
+Diseases الـ Tetralogy of Fallot اللي هو ربعية
+
+351
+00:36:29,980 --> 00:36:37,980
+Fallot أربع ظواهر Aortic Stenosis Ventricular
+
+352
+00:36:37,980 --> 00:36:43,130
+Septal Defect Overriding of the Aortaالـ Pulmonary
+
+353
+00:36:43,130 --> 00:36:46,710
+valve
+
+354
+00:36:46,710 --> 00:36:54,410
+stenosis والـ Atrial alarm يعني أربع ظواهر بخربط
+
+355
+00:36:54,410 --> 00:37:00,750
+الدموي بهذا الشكل بيصير سيانوسس بيصير خربطات
+
+356
+00:37:00,750 --> 00:37:06,350
+بالنسبة للقلب بشكل كبير كثير Hypoplastic lymph
+
+357
+00:37:06,350 --> 00:37:12,010
+vent heartيعني فيه مشكلة إنه تكون الـ left
+
+358
+00:37:12,010 --> 00:37:16,870
+ventricle بيصير ضعيف في حالة بيسموها aseptal
+
+359
+00:37:16,870 --> 00:37:24,270
+defect عبارة عن الفتحة بين الأذينين اليمين واليسار
+
+360
+00:37:24,270 --> 00:37:30,610
+اللي هي بتكون أصلاً مهمة في حالة الـ في المرحلة
+
+361
+00:37:30,610 --> 00:37:35,050
+الجنينية المرحلة الجنينية يعني أحنا ماعناش lungs
+
+362
+00:37:35,050 --> 00:37:40,250
+تاخد هووالإنسان في بطن أمه وفي الرحم فالـ
+
+363
+00:37:40,250 --> 00:37:45,430
+Oxygenated blood بيجي من الـ umbilical vein برجع
+
+364
+00:37:45,430 --> 00:37:53,670
+من الـ umbilica، من المشكيبة فالـ Oxygenated blood
+
+365
+00:37:53,670 --> 00:38:00,910
+اللي هو بيجي عن طريق الـ يعني هنا بدي يرجع للقلب
+
+366
+00:38:00,910 --> 00:38:07,940
+على الجهة اليمين عاديبروح بالإنسان الطبيعي، بدخل
+
+367
+00:38:07,940 --> 00:38:11,260
+من الـInferior Vena Cava بروح على طول على الـLeft
+
+368
+00:38:11,260 --> 00:38:13,880
+Atrium، على الـRight Atrium، بعدين على الـLeft
+
+369
+00:38:13,880 --> 00:38:17,180
+Atrium، بعدين على الـBody، هذا اللي هو الدم
+
+370
+00:38:17,180 --> 00:38:21,060
+الكويس، بتكون بهذا الشكل Co-architecture of the
+
+371
+00:38:21,060 --> 00:38:26,740
+aorta، برضه يعني ممكن تكون patent ductus
+
+372
+00:38:26,740 --> 00:38:32,220
+arteriosus، هذوله يعني برضه من الظواهر، هنا فيه
+
+373
+00:38:32,220 --> 00:38:39,600
+تضييبفي الأورطة
+
+374
+00:38:39,600 --> 00:38:44,800
+بعد اللفت subclavian وتكون على الـ anatomical site
+
+375
+00:38:44,800 --> 00:38:49,360
+تبع الدفتس أرتيوزس تبع الدفتس أرتيوزس هذه النقطة
+
+376
+00:38:49,360 --> 00:38:53,400
+الثانية اللي بتتم فيها تحويلات الدم في الفترة
+
+377
+00:38:53,400 --> 00:38:58,000
+الجنينية لما الإنسان يولد كل هذه المفروض تسكر فإذا
+
+378
+00:38:58,000 --> 00:39:02,280
+ما سكرتش أو سكرت زيادة بتعمل مرضالـ Arregulation
+
+379
+00:39:02,280 --> 00:39:04,920
+of the aorta بدي يخلّي الإنسان عنده ارتفاع في
+
+380
+00:39:04,920 --> 00:39:09,380
+الضغط في الأطراف العلوية وبالرجلين الضغط بيكون
+
+381
+00:39:09,380 --> 00:39:14,760
+واطق كثير لأن الدم مش قادر ينضخ بشكل سليم والـ
+
+382
+00:39:14,760 --> 00:39:19,220
+Patent of Arteriosis راح تخلي هبوط في الدورة
+
+383
+00:39:19,220 --> 00:39:26,420
+الدموية بسبب اختلاط الدم بين الدورة الكبرى والصغرى
+
+384
+00:39:26,420 --> 00:39:32,590
+وتكون بشكل متعب للقلب بسببيعني إنه بيشتغل على
+
+385
+00:39:32,590 --> 00:39:38,350
+الفاضي واختلال في دورة الدم فهذه كلها حالات في
+
+386
+00:39:38,350 --> 00:39:47,190
+منها إلها دخل بالنسبة للوراثة ويعني اللي
+
+387
+00:39:47,190 --> 00:39:52,910
+هي بيسموها الـ Risk Ratio كمعامل يعطينا كم مرة
+
+388
+00:39:52,910 --> 00:39:57,030
+أكثر من غيرهإذا كان لدى أحد في العائلة مشكلة
+
+389
+00:39:57,030 --> 00:40:00,950
+بالنسبة
+
+390
+00:40:00,950 --> 00:40:07,890
+للـ Population إذا كان لدى أحد في العائلة مشكلة
+
+391
+00:40:07,890 --> 00:40:13,630
+بالنسبة للحدوث في أبناء الآخرين يعني هنا كلها
+
+392
+00:40:13,630 --> 00:40:15,530
+مثلًا
+
+393
+00:40:16,730 --> 00:40:21,310
+النسب أقل يعني عشر بالمية وواحد بالألف وواحد
+
+394
+00:40:21,310 --> 00:40:26,410
+بالعشر تلات هنا بتصير كـPercentage إذا في واحد
+
+395
+00:40:26,410 --> 00:40:31,670
+مصاب بتوصل لثلاث بالمية أو أربع بالمية وهذه النسبة
+
+396
+00:40:31,670 --> 00:40:40,990
+ترتفع بـ30، 40، 50% زيادة فالـVSD أو الـCongenital
+
+397
+00:40:40,990 --> 00:40:45,530
+Heart Diseases إيه اللي دخل؟ وحكينا يعني مثال على
+
+398
+00:40:46,230 --> 00:40:50,270
+إذا بيذكروا الواحد من الـ Digorge Syndrome كيف إنه
+
+399
+00:40:50,270 --> 00:41:00,450
+فعلاً الوجود وجود حقيقةً subchromosomal deletion
+
+400
+00:41:00,450 --> 00:41:06,750
+وجودها بيخلّي أنه بيصير عند الطفل أو الـ newborn
+
+401
+00:41:06,750 --> 00:41:11,950
+congenital heart disease وهذه من المشاكل نتيجة
+
+402
+00:41:11,950 --> 00:41:13,630
+المادة الوراثية
+
+403
+00:41:17,260 --> 00:41:23,440
+الـ Schizophrenia والـ Bipolar Disorder برضه إلها
+
+404
+00:41:23,440 --> 00:41:29,260
+نسب عالية يعني تفاصيلها أمثلة على يعني ما بديهاش
+
+405
+00:41:29,260 --> 00:41:34,680
+أثبات أخذنا كلام عليها من قبل قضية الـ Coronary
+
+406
+00:41:34,680 --> 00:41:42,940
+Arthral Disease يعني اللي هي تسلط شراين القلب وشو
+
+407
+00:41:42,940 --> 00:41:53,590
+دخله وكذاهي دايماً التاريخ العائلي وحدوثها في قريب
+
+408
+00:41:53,590 --> 00:41:57,670
+من الدرجة الأولى حكيناها الأباء والأمهات والإخوان
+
+409
+00:41:57,670 --> 00:42:03,310
+والخوات والولاد والبنات دولة لأي إنسان بيكون من
+
+410
+00:42:03,310 --> 00:42:10,010
+عوامل الخطورة لتصلب شرايين الدم هذا برضه بيكون
+
+411
+00:42:10,010 --> 00:42:20,140
+موجودفهنا دراسات أخرى يعني الـ Monozygotic twins
+
+412
+00:42:20,140 --> 00:42:26,000
+إذا في واحد عنده إصابة، الثاني تقريبًا من ثمن إلى
+
+413
+00:42:26,000 --> 00:42:32,820
+خمستاشر مرة الإصابة بتكون أكبر، إذا Dizygotic
+
+414
+00:42:32,820 --> 00:42:40,660
+twins من مرتين لثلاثةمضاعفات في احتمالية الإصابة
+
+415
+00:42:40,660 --> 00:42:47,280
+بالتصلب الشرايين وبعدين حدوث احتشاق في عضلة القلب
+
+416
+00:42:47,280 --> 00:42:53,560
+ماشي هنا بـFatal Early Fatal Myocardial Infarction
+
+417
+00:42:53,560 --> 00:42:57,880
+يعني كانت نتيجة الوفاة كمان يعني نوعية شديدة أو
+
+418
+00:42:57,880 --> 00:43:05,820
+درجة شديدة من التصلب الشرايينفتصلب الشراين برضه
+
+419
+00:43:05,820 --> 00:43:13,320
+تتدخل فيه جينات كثيرة بس كمان فيه تأثيرات بيئية
+
+420
+00:43:13,320 --> 00:43:17,960
+كثيرة وهو من الحالات والمشاكل اللي نسميها
+
+421
+00:43:17,960 --> 00:43:22,700
+Multifactorial والـ Multifactorial جزء منه قضية
+
+422
+00:43:22,700 --> 00:43:27,020
+الورافة، نعم، فيه أسئلة
+
+423
+00:43:32,180 --> 00:43:37,620
+حالة أخرى Retinitis Pigmentosa بتكون من المسببات
+
+424
+00:43:37,620 --> 00:43:45,200
+من المسببات المرض
+
+425
+00:43:45,200 --> 00:43:51,100
+في الإبصار وإن واحد بيشوفش يعني هنا حاطينه مثال
+
+426
+00:43:51,100 --> 00:43:59,340
+على دراسة معينة كانت بسبب Diagenetic Inheritance
+
+427
+00:44:00,450 --> 00:44:07,670
+يعني هنا مثال لما اندرسوا عائلة لقوا عبارة عن كمان
+
+428
+00:44:07,670 --> 00:44:10,810
+اللي عامل الحالة هذه اللي هو Retinitis Pigmentosa
+
+429
+00:44:10,810 --> 00:44:18,510
+التلطخ أو تصبغ الشبكية تصبغ الشبكية في اللي هو
+
+430
+00:44:18,510 --> 00:44:27,850
+الـGene الأول ROM1والثاني اسمه الـ Peripheral
+
+431
+00:44:27,850 --> 00:44:37,650
+Locus اللي هو الجين الثاني وكيف انه تداخل الحالتين
+
+432
+00:44:37,650 --> 00:44:45,010
+يعني هنا داخلين أكثر في دراسة عن هذه الحالة علشان
+
+433
+00:44:45,010 --> 00:44:51,580
+يشوفوا أيش السببوإيش الـ «جين» اللي سببها في هذه
+
+434
+00:44:51,580 --> 00:44:58,260
+العائلتين يعني غير محظوظين إنه الناس عندهم بالأخير
+
+435
+00:44:58,260 --> 00:45:04,380
+موقعين مختلفين وبعاد تماماً بيأثروا على نفس الجهة
+
+436
+00:45:04,380 --> 00:45:11,840
+اللي هي الإبصار والشبكية في العيل فحيث إنه كانت
+
+437
+00:45:11,840 --> 00:45:23,200
+إنه سببت المرض لما نيجي ناخدكمان في الحالات
+
+438
+00:45:23,200 --> 00:45:32,160
+الوراثية بالنسبة للـ Clotting Factors اللي هو نقص
+
+439
+00:45:32,160 --> 00:45:38,380
+في الـ Factor 8 وFactor 9 اللي هم الـ Hemophilia
+
+440
+00:45:38,380 --> 00:45:43,100
+اللي هي قضية بنسميها النعور باللغة العربية النسف
+
+441
+00:45:43,100 --> 00:45:48,500
+الشديد وعدم تكون جلطات الدم وغيرهلما ندرس هذا
+
+442
+00:45:48,500 --> 00:45:55,500
+الموضوع لأ، فيه كمان جوانب أخرى على تجلط الدم اللي
+
+443
+00:45:55,500 --> 00:46:00,260
+دخل بطريقة Multifactorial وإنه دخل فيها أشياء
+
+444
+00:46:00,260 --> 00:46:06,040
+كثيرة فاكتر فايف لايدن، فيه الو Variant
+
+445
+00:46:06,040 --> 00:46:13,620
+وبروثرومبين، اللي هو الـFactor 2 اللي هو الرقم 2،
+
+446
+00:46:13,620 --> 00:46:19,270
+ماشي، برضه الو Variantالـ Fibrinogen رقم 1
+
+447
+00:46:19,270 --> 00:46:22,650
+فالتفاوت
+
+448
+00:46:22,650 --> 00:46:31,050
+في الـ Variation بالنسبة للـ Clotting Factor
+
+449
+00:46:31,050 --> 00:46:35,610
+Geneticsاللي له تداخل كمان بالـ Environmental
+
+450
+00:46:35,610 --> 00:46:40,070
+Factors مثال عليها كـ Environmental Factors أحد
+
+451
+00:46:40,070 --> 00:46:43,370
+أهم أسباب التجلطات اللي هو استخدام الـ Oral
+
+452
+00:46:43,370 --> 00:46:51,410
+Contraceptive Pills اللي هو الحب تمنع الحمل كهرمون
+
+453
+00:46:51,410 --> 00:46:59,650
+ثيرابي عشان يمنع الحمل فالفكرة
+
+454
+00:46:59,650 --> 00:47:01,530
+في الموضوع أنه
+
+455
+00:47:05,490 --> 00:47:12,810
+حسب الـ «جينيتيك فاكتور» والـ «جينيتيك ستاتوس»
+
+456
+00:47:12,810 --> 00:47:18,450
+وبعده بشكل متعدد العامل
+
+457
+00:47:18,450 --> 00:47:22,990
+البيئي زي الـ Oral Contraceptives بتلاقي إله دخل
+
+458
+00:47:22,990 --> 00:47:27,160
+إنه بيعمل مشاكلفالـ Factor 10 اللي ما محطينكم
+
+459
+00:47:27,160 --> 00:47:31,740
+إياها والـ Prothrombin اللي هو Factor 2 هدولة
+
+460
+00:47:31,740 --> 00:47:36,880
+ازدادوا بشكل كبير مع بعض الـ Variants of them مع
+
+461
+00:47:36,880 --> 00:47:41,980
+الـ Oral Contraceptivesفهي بتسبب إنه
+
+462
+00:47:41,980 --> 00:47:46,040
+«hypercoagulable state» يعني بتسبب إنه راح تسمح
+
+463
+00:47:46,040 --> 00:47:51,700
+إنه يصير جلطات وتصير مشاكل بسبب
+
+464
+00:47:51,700 --> 00:47:58,660
+تداخل عوامل وراثية وعوامل بيئية من الآن الأشياء
+
+465
+00:47:58,660 --> 00:48:02,060
+اللي تعتبر قوية في الأماكن دا في عند الواحد مجال
+
+466
+00:48:02,060 --> 00:48:11,340
+لدراستها اللي هو تأثيرالـ Warfarin على الـ الـ
+
+467
+00:48:11,340 --> 00:48:15,460
+طبعاً الـ Warfarin هو Blocker للـ Vitamin K اللي
+
+468
+00:48:15,460 --> 00:48:20,560
+هو بيثبت الـ Vitamin K dependent factors والواحد
+
+469
+00:48:20,560 --> 00:48:28,600
+بيحفظه كمعادلة أو كرقم 1972 فعشرة أو تسعة أو سبعة
+
+470
+00:48:28,600 --> 00:48:31,900
+أو اثنين كل ال factors تبعات الـ Coagulation
+
+471
+00:48:31,900 --> 00:48:36,260
+factors produced by the liver بتم إنتاجها من الكبد
+
+472
+00:48:36,740 --> 00:48:41,620
+والأربع هدولة Vitamin K-dependent طبعاً زاد بروتين
+
+473
+00:48:41,620 --> 00:48:47,380
+C وبروتين S فالآن فيه side effect قوي وبتصير مشاكل
+
+474
+00:48:47,380 --> 00:48:52,100
+من الوارثارين إذا فيه certain genetic mutation
+
+475
+00:48:52,100 --> 00:48:56,560
+فحتى من الآن اللي يسمونه personalized medicine
+
+476
+00:48:56,560 --> 00:49:04,140
+الأصل أنه يعني يدوروا على الـGenetic mutation هذه
+
+477
+00:49:04,600 --> 00:49:07,900
+وإذا فعلاً الإنسان عنده إياهة
+ما يعطوه الـ
+
+478
+00:49:07,900 --> 00:49:14,940
+Warfarin وبتأثر على كمية أو كيفية معالجته بالنسبة
+
+479
+00:49:14,940 --> 00:49:19,780
+للـ Carbohydrate
+
+480
+00:49:19,780 --> 00:49:28,540
+Factors في أسئلة؟ في حالة اسمها Herschsprung
+
+481
+00:49:28,540 --> 00:49:36,060
+Disease Herschsprung Disease من أمراضالجهاز الهضمي
+
+482
+00:49:36,060 --> 00:49:40,680
+والـ Motility تبعت الجهاز الهضمي برضه اللي دخل
+
+483
+00:49:40,680 --> 00:49:47,560
+بالبيئة وكمان أمراض كثيرة زي الـ Type 1 Diabetes
+
+484
+00:49:47,560 --> 00:49:51,780
+الـ Alzheimer وDementia
+
+485
+00:49:51,780 --> 00:50:02,000
+كيف إنه عدد كبير من الـ Genotypes جينات متعددة
+
+486
+00:50:02,400 --> 00:50:08,980
+طبعًا يعني مثلًا موضوع زي الـ Alzheimer اللي هو
+
+487
+00:50:08,980 --> 00:50:13,900
+الأصل يعني اللي واحد يتذكره كـPresenal Dementia
+
+488
+00:50:13,900 --> 00:50:19,900
+يعني الخرف المبكر الإنسان
+
+489
+00:50:19,900 --> 00:50:28,940
+حسب بيئته، حسب جيناته، حسب شو هو بتلاقي فيه تفاوت
+
+490
+00:50:28,940 --> 00:50:36,620
+في نسبة حدوث هذه الحالةوبتلاقي تعتمد
+
+491
+00:50:36,620 --> 00:50:45,700
+حسب يعني عدد مش قليل من الـ الـ mutations وكذا
+
+492
+00:50:45,700 --> 00:50:50,600
+ولكن أيضًا إله دخل بالبيئة يعنيزي ما دائمًا بيحكوا
+
+493
+00:50:50,600 --> 00:50:54,760
+كثير إذا مثلًا واحد بيحفظ قرآن إذا الواحد دائمًا
+
+494
+00:50:54,760 --> 00:51:00,880
+بنشط عقله مثلًا بيلعب لعبة زي اللي فيها رياضيات
+
+495
+00:51:00,880 --> 00:51:06,180
+وتفكير وحساب زي لعبة سودوكو مثلًا ودائمًا بيظل
+
+496
+00:51:06,180 --> 00:51:14,440
+يمرن عقله الإنسان بتلاقي بأخر حدوث الخرف وبيظل
+
+497
+00:51:14,440 --> 00:51:20,370
+محاصر على قوة العقلية مدة أطول أحيانًا زي ذلكفكل
+
+498
+00:51:20,370 --> 00:51:29,910
+أشياء أمثلة على أمراض وحالات بيكون
+
+499
+00:51:29,910 --> 00:51:34,170
+الصفة
+
+500
+00:51:34,170 --> 00:51:42,550
+الأغلب فيها والأعام هي أنها تشترك فيها جوانب
+
+501
+00:51:42,550 --> 00:51:50,820
+وراثية وجوانب جينيةبطرق مختلفة ومتفاوتة ومتعددة مع
+
+502
+00:51:50,820 --> 00:51:55,220
+عوامل بيئية بتلاقيها في البيئة في أشياء معينة
+
+503
+00:51:55,220 --> 00:51:59,860
+بتخلي الواحد يسير عنده فبالنسبة لمحاضرة اليوم هذه
+
+504
+00:51:59,860 --> 00:52:09,460
+الأشياء اللي أمثل عليها يعني أنا بظن إن الواحد إذا
+
+505
+00:52:09,460 --> 00:52:15,060
+بده يركز شوية على إن الأمثل الكرومزومية يحفظها
+
+506
+00:52:15,060 --> 00:52:22,670
+مظبوطلأن عددها قليل وأمثلتها قليلة بالذات الرئيسية
+
+507
+00:52:22,670 --> 00:52:28,770
+منها وبالنسبة لـ «ماندالين» يتكلم عن مشهورات منهم
+
+508
+00:52:28,770 --> 00:52:36,130
+المعرفات والأساسيات وبالنسبة للمجموعة الكبرى يعني
+
+509
+00:52:36,130 --> 00:52:43,270
+كل الأسماء الأمراض اللي عرضناهم يتذكر الواحد إنه
+
+510
+00:52:43,270 --> 00:52:45,570
+Multifactorial
+
+511
+00:52:46,510 --> 00:52:51,090
+ما دخلناش كثير في مثال مثلًا مثلًا مثلًا مثلًا
+
+512
+00:52:51,090 --> 00:52:51,650
+مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا
+
+513
+00:52:51,650 --> 00:52:56,810
+مثلًا مثلًا مثلًا مثلًا مثلًا
+
+514
+00:52:56,810 --> 00:53:01,150
+مثلًا
+
+515
+00:53:01,150 --> 00:53:02,270
+مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا
+
+516
+00:53:02,270 --> 00:53:02,270
+مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا
+
+517
+00:53:02,270 --> 00:53:02,270
+مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا
+
+518
+00:53:02,270 --> 00:53:03,410
+مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا
+
+519
+00:53:03,410 --> 00:53:13,030
+مثلًا مثلًا
+
+520
+00:53:13,030 --> 00:53:19,260
+مثلًاالـ Whole Genome Sequencing يعني أنه تقدر
+
+521
+00:53:19,260 --> 00:53:25,780
+الواحد يقرأ شو نيوكليوتاد تبع كل الـ DNA تبع أي
+
+522
+00:53:25,780 --> 00:53:34,400
+إنسان، ماشي، بصير تعطيني يعني مرجع إن إذا أنا عند
+
+523
+00:53:34,400 --> 00:53:40,460
+عائلة كبيرة مثلا أو مجموعة معينة من البشروبكون
+
+524
+00:53:40,460 --> 00:53:46,180
+أقدر أقارن بين المصابين وغير المصابين ليش هذا أصيب
+
+525
+00:53:46,180 --> 00:53:52,600
+وليش هذا لم يصيب في الـ Whole Genome Sequencing من
+
+526
+00:53:52,600 --> 00:53:58,520
+أحد التقنيات اللي راحت تشوفوا أنها بتقدر تفيدها
+
+527
+00:53:58,520 --> 00:54:09,180
+وفي جانب آخر قضية دراسة كمية شغل الـ Geneيعني مش
+
+528
+00:54:09,180 --> 00:54:14,420
+كل الـ «جين» في كل الخلايا شغالة بنفس الدرجة لأ،
+
+529
+00:54:14,420 --> 00:54:18,400
+حسب مثلا الـ «جين» تبع الـ «هيموجلوبين» بضرب دائما
+
+530
+00:54:18,400 --> 00:54:22,720
+مثال بس في الـ «رد بلد سيلز» بيكون شغال في باقية
+
+531
+00:54:22,720 --> 00:54:27,900
+الخلايا ما له دخله، بقى بتم استخدامه فحتى بالنسبة
+
+532
+00:54:27,900 --> 00:54:33,860
+لـ «هيموجلوبين» الـ «جين» درجة فعليته كم نسخة RNA
+
+533
+00:54:33,860 --> 00:54:40,330
+ناتج عنهفبالتالي، يعني ممكن الإنسان العالم يعني
+
+534
+00:54:40,330 --> 00:54:45,510
+قصدي في الدراسة نشوف اختلاف أو تفاوت في نشاط
+
+535
+00:54:45,510 --> 00:54:48,250
+الجينات اللي هو يعني الـ Epigenetic Control اللي
+
+536
+00:54:48,250 --> 00:54:56,750
+حكينا عنه هذه لها طرق دراسة معينة ممكن نتيجتها
+
+537
+00:54:56,750 --> 00:55:02,730
+الواحد يكون يعرف إيش الجينات المسؤولة بنشاطة عن
+
+538
+00:55:02,730 --> 00:55:09,030
+حدوث مرض معينيعني هذه الـ الـ يعني الـ gene
+
+539
+00:55:09,030 --> 00:55:18,510
+expression بتكون إنه إحنا بندرس بشكل عام درجة نشاط
+
+540
+00:55:18,510 --> 00:55:25,260
+الجينات كلها بمين اللي زايدات ومين اللي ناقصاتوهذه
+
+541
+00:55:25,260 --> 00:55:31,400
+بتكون باستخدام Markers معينة وبتكون أساليب دراسة
+
+542
+00:55:31,400 --> 00:55:38,920
+لما واحد يقرأ عنها بتلاقيها ممكن تكون مفيدة فاليوم
+
+543
+00:55:38,920 --> 00:55:44,620
+المحاضرة قصيرة، مافيش فيها أفكار كثيرة بالنسبة
+
+544
+00:55:44,620 --> 00:55:51,400
+لـ’’ يعني بالنسبة لـ’’ أنه المطلوب بالنسبة للجينات
+
+545
+00:55:51,400 --> 00:55:55,630
+لهذهالأمراض، لأ، ما بيداشيها كثير كثير يعني
+
+546
+00:55:55,630 --> 00:56:00,430
+بالنسبة شوهيها بقدر ما أنه فيه عدد كبير من الجينات
+
+547
+00:56:00,430 --> 00:56:03,870
+يعني أقل واحد واللي حطوا عنه مثال اللي هو الـ
+
+548
+00:56:03,870 --> 00:56:08,010
+Retinitis Pigmentosa إنه فيها جينين عملات مشكلة
+
+549
+00:56:08,010 --> 00:56:11,430
+فيه
+
+550
+00:56:11,430 --> 00:56:18,650
+أسئلة أسئلة عن الجزء هذا أو الأجزاء السابقة
+
+551
+00:56:31,300 --> 00:56:39,220
+هنا، دعنا نشوف، Remote Control، Chat،
+
+552
+00:56:39,220 --> 00:56:47,860
+ماشي، دكتور أحمد، في أسئلة؟ اليوم، الحلقة أقصر من
+
+553
+00:56:47,860 --> 00:56:54,620
+غيرها شوية، أصل مفاهيمها يعني، الحمد لله، يعني
+
+554
+00:56:54,620 --> 00:56:57,700
+مطلوب المعلومة العامة يعني، أه
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/d-MRFWD54MU_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/d-MRFWD54MU_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..e499f5193174c9a755ccae2308c49c2f11bfa3e4
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/d-MRFWD54MU_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2852, "start": 0.0, "end": 28.52, "text": "وهو الـ Single Gene Inheritance اللي هما الـ Mandelian Diseases حكيت أنا يعني من قبل أنه في عنا عدد أمثلة قليل عادة لـ Chromosomal Disease الـ Chromosomal Disease لما يكون كرموزوم كامل أو جزء من كرموزوم بيصير فيه مشكلة زي Deletion، Copy Number", "tokens": [2407, 3224, 2407, 2423, 39184, 31248, 18083, 682, 511, 270, 719, 13672, 1829, 8032, 15042, 2423, 39184, 15458, 338, 952, 30161, 1957, 11331, 4117, 36081, 41850, 37495, 22653, 9154, 12174, 36150, 14739, 3224, 8978, 6225, 8315, 6225, 3215, 3215, 5551, 2304, 12984, 37977, 12174, 20292, 1211, 6225, 18513, 3660, 5296, 39184, 1721, 40934, 298, 304, 35360, 2423, 39184, 1721, 40934, 298, 304, 35360, 5296, 15042, 7251, 30544, 9122, 2288, 2304, 2407, 11622, 20498, 9122, 10943, 1211, 34051, 10874, 11622, 38207, 9154, 9122, 2288, 2304, 2407, 11622, 20498, 4724, 1829, 9381, 13546, 8978, 3224, 37893, 28820, 3660, 30767, 1829, 5831, 302, 313, 12399, 25653, 5118], 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Anti-A ولا فيه Anti-B فهذه قضية يعني بتكون موجودة وبتكون بهذا الطريقة وبهذا الشكل فهذا مثال على Locus يعني على مكان للجينات هذه وفي عندنا three alleles possible يعني الـ Genotype", "tokens": [41185, 2423, 39184, 4210, 449, 43242, 3224, 19446, 8978, 3224, 27757, 12, 32, 49429, 8978, 3224, 27757, 12, 33, 6156, 3224, 24192, 12174, 11242, 10632, 37495, 22653, 39894, 30544, 3714, 29245, 23328, 3660, 46599, 2655, 30544, 39627, 15730, 41950, 16572, 28671, 46599, 3224, 15730, 25124, 28820, 6156, 3224, 15730, 50113, 6027, 15844, 12859, 301, 37495, 22653, 15844, 3714, 41361, 24976, 7435, 1829, 8315, 2655, 29538, 4032, 41185, 43242, 8315, 1045, 439, 6972, 1944, 37495, 22653, 2423, 39184, 3632, 13108], "avg_logprob": -0.23964844066649676, "compression_ratio": 1.5609756097560976, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 821.1, "end": 821.28, "word": "في", "probability": 0.791015625}, {"start": 821.28, "end": 821.48, "word": " الـ", "probability": 0.778564453125}, {"start": 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0.846435546875}], "temperature": 1.0}, {"id": 31, "seek": 87909, "start": 850.79, "end": 879.09, "text": "اللي هو القليل الممكن في هذا المكان يا «O» يا «A» يا «B» والـ «Phenotypes» الممكن أربعة يا «O» يا «A» يا «B» يا «AB» مع ملاحظة أنه لما يكون «A» لأن الـ «A» dominant على الـ «O» في الـ possibilities تكون «AA» أو «AO» والـ «B» لما يكون الـ «Phenotype» «B» يا إما «BB»", "tokens": [6027, 20292, 31439, 25062, 20292, 1211, 9673, 43020, 8978, 23758, 9673, 41361, 35186, 4657, 46, 5933, 35186, 4657, 32, 5933, 35186, 4657, 33, 5933, 16070, 39184, 4657, 47, 2932, 19477, 5933, 9673, 43020, 5551, 25513, 27884, 35186, 4657, 46, 5933, 35186, 4657, 32, 5933, 35186, 4657, 33, 5933, 35186, 4657, 13868, 5933, 20449, 3714, 15040, 5016, 19913, 3660, 14739, 3224, 5296, 15042, 7251, 30544, 4657, 32, 5933, 5296, 33456, 2423, 39184, 4657, 32, 5933, 15657, 15844, 2423, 39184, 4657, 46, 5933, 8978, 2423, 39184, 12178, 6055, 30544, 4657, 5265, 5933, 34051, 4657, 32, 46, 5933, 16070, 39184, 4657, 33, 5933, 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"probability": 0.704345703125}, {"start": 875.01, "end": 875.63, "word": " «B»", "probability": 0.96337890625}, {"start": 875.63, "end": 875.99, "word": " لما", "probability": 0.983154296875}, {"start": 875.99, "end": 876.31, "word": " يكون", "probability": 0.96337890625}, {"start": 876.31, "end": 876.53, "word": " الـ", "probability": 0.935302734375}, {"start": 876.53, "end": 876.97, "word": " «Phenotype»", "probability": 0.83447265625}, {"start": 876.97, "end": 877.83, "word": " «B»", "probability": 0.8196614583333334}, {"start": 877.83, "end": 878.03, "word": " يا", "probability": 0.62939453125}, {"start": 878.03, "end": 878.25, "word": " إما", "probability": 0.932373046875}, {"start": 878.25, "end": 879.09, "word": " «BB»", "probability": 0.9588216145833334}], "temperature": 1.0}, {"id": 32, "seek": 90898, "start": 879.22, "end": 908.98, "text": "كـ Genotype أو «بو» كـ Genotype فهي المفاهيم لازم واحد يكون مستوعبها وسهلة وغاضبة عنده فلمّا نيجي نشوف كيف بيصير الـ Inheritance وعلى أي أساس يعني أنا بصير بعدين أحكم إنه هاي هيك، هاي هيك، هاي هيك", "tokens": [4117, 39184, 3632, 13108, 34051, 4657, 3555, 2407, 5933, 9122, 39184, 3632, 13108, 6156, 3224, 1829, 9673, 5172, 40294, 32640, 5296, 31377, 2304, 36764, 24401, 7251, 30544, 3714, 14851, 45367, 3555, 11296, 46952, 3224, 37977, 4032, 17082, 46958, 49401, 43242, 3224, 6156, 19528, 11703, 995, 8717, 1829, 7435, 1829, 8717, 8592, 38688, 9122, 33911, 4724, 1829, 9381, 13546, 2423, 39184, 682, 511, 270, 719, 4032, 3615, 23942, 36632, 5551, 3794, 32277, 37495, 22653, 41850, 4724, 9381, 13546, 39182, 9957, 5551, 5016, 24793, 36145, 3224, 8032, 47302, 39896, 4117, 12399, 8032, 47302, 39896, 4117, 12399, 8032, 47302, 39896, 4117], "avg_logprob": -0.21732954876591462, "compression_ratio": 1.5446009389671362, "no_speech_prob": 1.6689300537109375e-06, "words": [{"start": 879.22, "end": 879.68, "word": "كـ", "probability": 0.7086181640625}, {"start": 879.68, "end": 880.34, "word": " Genotype", "probability": 0.751708984375}, 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مثلًا مثال نرجع بعد شوية بقى دي أنا بشوف عندي إنسان في الحالة هذه شخصين من أسرة مصابين ولد وابنت ماشي أو يعني حتى صار كبار بالعمر بحيث أنه", "tokens": [1211, 2407, 5551, 9778, 3215, 8315, 50113, 1211, 14111, 995, 50113, 6027, 8717, 47341, 3615, 39182, 13412, 2407, 10632, 4724, 4587, 7578, 11778, 1829, 41850, 4724, 8592, 38688, 18871, 16254, 36145, 3794, 7649, 8978, 21542, 6027, 3660, 29538, 13412, 9778, 9381, 9957, 9154, 5551, 3794, 25720, 3714, 9381, 16758, 9957, 35525, 3215, 4032, 16758, 29399, 3714, 33599, 1829, 34051, 37495, 22653, 11331, 49975, 20328, 9640, 9122, 3555, 9640, 20666, 25957, 2288, 4724, 5016, 1829, 12984, 14739, 3224], "avg_logprob": -0.18760015471623495, "compression_ratio": 1.6603773584905661, "no_speech_prob": 0.0, "words": [{"start": 909.78, "end": 910.06, "word": "لو", "probability": 0.7386474609375}, {"start": 910.06, "end": 910.48, "word": " أخدنا", "probability": 0.9002685546875}, {"start": 910.48, "end": 910.88, "word": " مثلًا", "probability": 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"start": 1351.18, "end": 1379.76, "text": "لكن هاد أنت الـ «unaffected carriers» بنعتبرها لحظة مثلا في النسبة اللي قدام في الأسئلة أو في الاختبارات لازم نحكي أن الـ «unaffected carrier» نص والـ «unaffected» لحالها ربيع والـ «unaffected» لحالها ربيع ولكن أنت اللي فوق مع بعض لأ إذا في سؤال طالب بشكل تفصيلي يعني أنت هنا مهين بيني ربع", "tokens": [1211, 19452, 8032, 18513, 14739, 2655, 2423, 39184, 4657, 409, 2518, 39963, 28541, 5933, 44945, 34268, 26890, 11296, 5296, 5016, 19913, 3660, 50113, 15040, 8978, 28239, 35457, 3660, 13672, 1829, 12174, 3215, 10943, 8978, 16247, 3794, 19986, 37977, 34051, 8978, 2423, 47283, 2655, 3555, 9640, 9307, 5296, 31377, 2304, 8717, 5016, 4117, 1829, 14739, 2423, 39184, 4657, 409, 2518, 39963, 17574, 5933, 8717, 9381, 4032, 6027, 39184, 4657, 409, 2518, 39963, 5933, 5296, 5016, 6027, 11296, 12602, 21292, 3615, 4032, 6027, 39184, 4657, 409, 2518, 39963, 5933, 5296, 5016, 6027, 11296, 12602, 21292, 3615, 35525, 19452, 14739, 2655, 13672, 1829, 6156, 30543, 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females قط بعض أو في إمكانية يحدث للإثنين أن يكون males و females فهذه ثلاث أجيال في عائلة معينة ونلاقي إن المصابين فقط هم الـ males", "tokens": [2407, 3224, 15730, 1970, 14739, 6055, 30544, 1476, 329, 298, 304, 37495, 22653, 11331, 4117, 1829, 8315, 5296, 15042, 6055, 30544, 13412, 17082, 37977, 1476, 329, 298, 304, 16247, 36520, 7251, 30544, 20776, 4032, 21529, 12174, 9566, 45030, 11242, 34051, 8978, 11933, 2304, 41361, 10632, 7251, 24401, 12984, 24976, 28814, 12984, 1863, 9957, 14739, 7251, 30544, 20776, 4032, 21529, 6156, 3224, 24192, 38637, 1211, 5718, 104, 5551, 7435, 1829, 6027, 8978, 6225, 16373, 37977, 20449, 9957, 3660, 4032, 1863, 15040, 38436, 36145, 9673, 9381, 16758, 9957, 6156, 47432, 8032, 2304, 2423, 39184, 20776], "avg_logprob": -0.2509973369380261, "compression_ratio": 1.7085427135678393, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2288.89, "end": 2289.53, "word": "وهذا", "probability": 0.8258463541666666}, {"start": 2289.53, "end": 2290.25, "word": 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0.65625}, {"start": 2978.22, "end": 2979.18, "word": " heterozygous", "probability": 0.94541015625}, {"start": 2979.18, "end": 2979.92, "word": " يعني", "probability": 0.77197265625}], "temperature": 1.0}, {"id": 110, "seek": 300525, "start": 2980.49, "end": 3005.25, "text": "هو heterozygous لأنه لم يكنتان زي بعض يعني هنا إذا بدي أرسم لها مثال فأنا هنا مثلا H capital H small وخلّيني أسميها H one وH two small على small فهنا بلاقي X H small one", "tokens": [3224, 2407, 3639, 2032, 1229, 70, 563, 5296, 33456, 3224, 32767, 7251, 19452, 2655, 7649, 30767, 1829, 45030, 11242, 37495, 22653, 34105, 11933, 15730, 4724, 16254, 5551, 2288, 38251, 5296, 11296, 50113, 6027, 6156, 10721, 8315, 34105, 50113, 15040, 389, 4238, 389, 1359, 4032, 9778, 1211, 11703, 9957, 1829, 5551, 38251, 1829, 11296, 389, 472, 4032, 39, 732, 1359, 15844, 1359, 6156, 3224, 8315, 4724, 15040, 38436, 1783, 389, 1359, 472], "avg_logprob": -0.3324652819169892, "compression_ratio": 1.398876404494382, "no_speech_prob": 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"seek": 308959, "start": 3064.09, "end": 3089.59, "text": "سنأخذ مثلًا الـ Hemoglobin & Pathies في الـ S-Hemoglobin اللي فيه تبع الـ Sickles اللي في محل معين وفي الـ C-Hemoglobin اللي بيكون خلل ثاني في محل ثاني ففيه بيطلع لي حد عنده بيسموه SC-Hemoglobin هذا بيكون نسخة مصابة بالمحل الـ S ونسخة مصابة بالمحل الـ C فهذا بتسميه compound heterozygous", "tokens": [3794, 1863, 10721, 9778, 8848, 50113, 1211, 14111, 995, 2423, 39184, 18568, 45841, 13496, 3693, 21914, 530, 8978, 2423, 39184, 318, 12, 39, 443, 45841, 13496, 13672, 1829, 8978, 3224, 6055, 3555, 3615, 2423, 39184, 43471, 904, 13672, 1829, 8978, 3714, 5016, 1211, 20449, 9957, 4032, 41185, 2423, 39184, 383, 12, 39, 443, 45841, 13496, 13672, 1829, 4724, 1829, 30544, 16490, 1211, 1211, 38637, 7649, 1829, 8978, 3714, 5016, 1211, 38637, 7649, 1829, 6156, 41185, 3224, 4724, 1829, 9566, 1211, 3615, 32239, 11331, 3215, 43242, 3224, 4724, 1829, 38251, 2407, 3224, 9028, 12, 39, 443, 45841, 13496, 23758, 4724, 1829, 30544, 8717, 3794, 9778, 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"هي Dominant Inheritance بس لما يكون فيه فرق بين الأب والأم إذا مصابين بهذا الشكل ماشي بتعطيني Indicator إنه هاي X-Link Dominant Inheritance يعني هنا حاطين مثال هذا زلمة الـGeneration الأول مصاب أعطى بناته", "tokens": [3224, 1829, 18027, 394, 682, 511, 270, 719, 4724, 3794, 5296, 15042, 7251, 30544, 8978, 3224, 6156, 2288, 4587, 49374, 16247, 3555, 16070, 10721, 2304, 11933, 15730, 3714, 9381, 16758, 9957, 39627, 15730, 25124, 28820, 3714, 33599, 1829, 39894, 3615, 9566, 9957, 1829, 2333, 299, 1639, 36145, 3224, 8032, 47302, 1783, 12, 26822, 18027, 394, 682, 511, 270, 719, 37495, 22653, 34105, 11331, 41193, 9957, 50113, 6027, 23758, 30767, 19528, 3660, 2423, 39184, 26647, 5053, 16247, 12610, 3714, 9381, 16758, 5551, 3615, 9566, 7578, 4724, 8315, 47395], "avg_logprob": -0.21111506172879177, "compression_ratio": 1.5294117647058822, "no_speech_prob": 2.5033950805664062e-06, "words": [{"start": 3824.95, "end": 3826.45, "word": "هي", "probability": 0.53564453125}, {"start": 3826.45, "end": 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بنات وذكور مصابين وفي كل generation، ماشي فهي على الأقل بتعطيني Indicator إنه هذه عبارة عن dominant", "tokens": [2304, 33599, 1829, 6156, 3224, 1863, 3714, 9381, 16758, 9307, 29739, 8315, 2655, 5296, 15042, 8717, 2655, 11622, 29245, 1863, 4724, 43042, 3224, 8978, 3224, 4724, 8315, 2655, 4032, 8848, 4117, 13063, 3714, 9381, 16758, 9957, 4032, 41185, 28242, 5125, 12399, 3714, 33599, 1829, 6156, 3224, 1829, 15844, 16247, 4587, 1211, 39894, 3615, 9566, 9957, 1829, 2333, 299, 1639, 36145, 3224, 29538, 6225, 3555, 9640, 3660, 18871, 15657], "avg_logprob": -0.25430253277654236, "compression_ratio": 1.4036144578313252, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 3855.02, "end": 3855.52, "word": "ماشي", "probability": 0.63739013671875}, {"start": 3855.52, "end": 3856.02, "word": " فهن", "probability": 0.7200520833333334}, {"start": 3856.02, "end": 3856.86, "word": " مصابات", "probability": 0.9427490234375}, {"start": 3856.86, "end": 3858.64, "word": " البنات", "probability": 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ثانية أو بلاحظ ناحية معينة إنه لما يكون المصاب ذكر ماشي", "tokens": [4575, 511, 270, 719, 29538, 4724, 15042, 14739, 8978, 28242, 16247, 7435, 1829, 6027, 8978, 8717, 32277, 3714, 9381, 16758, 9957, 36145, 3224, 18027, 394, 34367, 77, 4724, 3794, 21542, 6027, 3660, 29538, 3714, 33599, 10632, 37495, 22653, 11933, 15730, 4724, 15040, 5016, 19913, 13412, 17082, 1211, 38637, 7649, 10632, 34051, 4724, 15040, 5016, 19913, 8717, 39319, 10632, 20449, 9957, 3660, 36145, 3224, 5296, 15042, 7251, 30544, 9673, 9381, 16758, 29910, 37983, 3714, 33599, 1829], "avg_logprob": -0.22697368832795242, "compression_ratio": 1.510989010989011, "no_speech_prob": 6.496906280517578e-06, "words": [{"start": 3879.44, "end": 3880.42, "word": "Inheritance", "probability": 0.7032318115234375}, {"start": 3880.42, "end": 3880.96, "word": " هذه", "probability": 0.1632080078125}, {"start": 3880.96, "end": 3881.74, "word": " بما", "probability": 0.8232421875}, {"start": 3881.74, "end": 3881.92, "word": " أن", 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الأول كانت مصابة ماشي، زوجها اتوفى، طبيعي كان الملاحظ، ماشي، هذه X-linked dominant inheritance الملاحظ أن الـFemales هم الوحيديات الـaffected وكل Generation", "tokens": [5172, 3224, 24192, 2423, 39184, 16689, 328, 701, 18863, 16373, 37977, 5551, 12610, 44049, 38207, 25724, 3215, 20666, 39184, 23898, 16247, 12610, 25961, 2655, 3714, 9381, 16758, 3660, 3714, 33599, 1829, 12399, 30767, 29245, 11296, 1975, 2655, 38688, 7578, 12399, 23032, 21292, 3615, 1829, 25961, 9673, 15040, 5016, 19913, 12399, 3714, 33599, 1829, 12399, 29538, 1783, 12, 22473, 292, 15657, 32122, 9673, 15040, 5016, 19913, 14739, 2423, 39184, 37, 443, 4229, 8032, 2304, 2423, 2407, 5016, 25708, 1829, 9307, 2423, 39184, 2518, 39963, 4032, 28820, 23898], "avg_logprob": -0.2176724144782143, "compression_ratio": 1.4976744186046511, "no_speech_prob": 0.0, "words": [{"start": 4347.15, "end": 4347.97, "word": "فهذه", "probability": 0.5345865885416666}, {"start": 4347.97, "end": 4348.07, "word": " الـ", "probability": 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"word": " زوجها", "probability": 0.9933268229166666}, {"start": 4358.93, "end": 4359.55, "word": " اتوفى،", "probability": 0.804443359375}, {"start": 4359.55, "end": 4359.95, "word": " طبيعي", "probability": 0.9847412109375}, {"start": 4359.95, "end": 4360.37, "word": " كان", "probability": 0.97607421875}, {"start": 4360.37, "end": 4363.23, "word": " الملاحظ،", "probability": 0.883984375}, {"start": 4363.23, "end": 4364.81, "word": " ماشي،", "probability": 0.879638671875}, {"start": 4364.81, "end": 4365.57, "word": " هذه", "probability": 0.63330078125}, {"start": 4365.57, "end": 4366.97, "word": " X", "probability": 0.82275390625}, {"start": 4366.97, "end": 4367.57, "word": "-linked", "probability": 0.7825520833333334}, {"start": 4367.57, "end": 4368.01, "word": " dominant", "probability": 0.81396484375}, {"start": 4368.01, "end": 4368.89, "word": " inheritance", "probability": 0.95654296875}, {"start": 4368.89, "end": 4370.23, "word": " الملاحظ", "probability": 0.985595703125}, {"start": 4370.23, "end": 4370.73, "word": " أن", "probability": 0.478271484375}, {"start": 4370.73, "end": 4372.07, "word": " الـFemales", "probability": 0.765869140625}, {"start": 4372.07, "end": 4372.33, "word": " هم", "probability": 0.92138671875}, {"start": 4372.33, "end": 4372.99, "word": " الوحيديات", "probability": 0.880859375}, {"start": 4372.99, "end": 4373.77, "word": " الـaffected", "probability": 0.6988525390625}, {"start": 4373.77, "end": 4374.81, "word": " وكل", "probability": 0.866455078125}, {"start": 4374.81, "end": 4375.39, "word": " Generation", "probability": 0.8701171875}], "temperature": 1.0}, {"id": 163, "seek": 440555, "start": 4377.59, "end": 4405.55, "text": "وكل generation فيه مصابين أو مصابات في الحالة هذه فهذا disease الـ X-linked dominant inheritance ماشي، الـ males hemizygous for a premature termination المالز بياخدوا من الأم one copy", "tokens": [2407, 28820, 5125, 8978, 3224, 3714, 9381, 16758, 9957, 34051, 3714, 9381, 16758, 9307, 8978, 21542, 6027, 3660, 29538, 6156, 3224, 15730, 4752, 2423, 39184, 1783, 12, 22473, 292, 15657, 32122, 3714, 33599, 1829, 12399, 2423, 39184, 20776, 8636, 590, 18103, 563, 337, 257, 34877, 1433, 2486, 9673, 6027, 11622, 4724, 1829, 47283, 3215, 14407, 9154, 16247, 2304, 472, 5055], "avg_logprob": -0.3078893364452925, "compression_ratio": 1.3262032085561497, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 4377.59, "end": 4378.81, "word": "وكل", "probability": 0.806396484375}, {"start": 4378.81, "end": 4379.37, "word": " generation", "probability": 0.043365478515625}, {"start": 4379.37, "end": 4379.89, "word": " فيه", "probability": 0.764892578125}, {"start": 4379.89, "end": 4380.57, "word": " مصابين", "probability": 0.95849609375}, {"start": 4380.57, "end": 4380.81, "word": " أو", "probability": 0.9541015625}, {"start": 4380.81, "end": 4381.39, "word": " مصابات", "probability": 0.8760986328125}, {"start": 4381.39, "end": 4381.51, "word": " في", "probability": 0.912109375}, {"start": 4381.51, "end": 4381.93, "word": " الحالة", "probability": 0.9225260416666666}, {"start": 4381.93, "end": 4382.27, "word": " هذه", "probability": 0.9208984375}, {"start": 4382.27, "end": 4383.83, "word": " فهذا", "probability": 0.8351236979166666}, {"start": 4383.83, "end": 4384.47, "word": " disease", "probability": 0.259765625}, {"start": 4384.47, "end": 4387.23, "word": " الـ", "probability": 0.776611328125}, {"start": 4387.23, "end": 4387.63, "word": " X", "probability": 0.79541015625}, {"start": 4387.63, "end": 4388.11, "word": "-linked", "probability": 0.80859375}, {"start": 4388.11, "end": 4388.61, "word": " dominant", "probability": 0.8896484375}, {"start": 4388.61, "end": 4389.67, "word": " inheritance", "probability": 0.97900390625}, {"start": 4389.67, "end": 4391.41, "word": " ماشي،", "probability": 0.608123779296875}, {"start": 4391.41, "end": 4391.67, "word": " الـ", "probability": 0.728759765625}, {"start": 4391.67, "end": 4392.05, "word": " males", "probability": 0.7265625}, {"start": 4392.05, "end": 4393.45, "word": " hemizygous", "probability": 0.683624267578125}, {"start": 4393.45, "end": 4396.07, "word": " for", "probability": 0.767578125}, {"start": 4396.07, "end": 4396.39, "word": " a", "probability": 0.94921875}, {"start": 4396.39, "end": 4397.03, "word": " premature", "probability": 0.93505859375}, {"start": 4397.03, "end": 4398.31, "word": " termination", "probability": 0.97265625}, {"start": 4398.31, "end": 4400.65, "word": " المالز", "probability": 0.59326171875}, {"start": 4400.65, "end": 4402.63, "word": " بياخدوا", "probability": 0.696630859375}, {"start": 4402.63, "end": 4402.87, "word": " من", "probability": 0.99609375}, {"start": 4402.87, "end": 4403.81, "word": " الأم", "probability": 0.97216796875}, {"start": 4403.81, "end": 4405.09, "word": " one", "probability": 0.85205078125}, {"start": 4405.09, "end": 4405.55, "word": " copy", "probability": 0.98046875}], "temperature": 1.0}, {"id": 164, "seek": 443180, "start": 4406.2, "end": 4431.8, "text": "والأم يعني لازم تكون تظامن X-linked dominant فالأم في الحالة هذه مستحيل تكون homozygous للـ Two copies تكون مصابات لأنه فيه من بناتها فيه مصابات وفيه طبيعيات ماشي ففيه مصابات وفيه طبيعيات", "tokens": [2407, 6027, 10721, 2304, 37495, 22653, 5296, 31377, 2304, 6055, 30544, 6055, 19913, 10943, 1863, 1783, 12, 22473, 292, 15657, 6156, 6027, 10721, 2304, 8978, 21542, 6027, 3660, 29538, 3714, 14851, 5016, 26895, 6055, 30544, 3655, 78, 1229, 70, 563, 24976, 39184, 4453, 14341, 6055, 30544, 3714, 9381, 16758, 9307, 5296, 33456, 3224, 8978, 3224, 9154, 4724, 8315, 2655, 11296, 8978, 3224, 3714, 9381, 16758, 9307, 4032, 41185, 3224, 23032, 21292, 3615, 1829, 9307, 3714, 33599, 1829, 6156, 41185, 3224, 3714, 9381, 16758, 9307, 4032, 41185, 3224, 23032, 21292, 3615, 1829, 9307], "avg_logprob": -0.21841398169917445, "compression_ratio": 1.701657458563536, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 4406.2, "end": 4407.9, "word": "والأم", "probability": 0.7686767578125}, {"start": 4407.9, "end": 4408.74, "word": " يعني", "probability": 0.53662109375}, {"start": 4408.74, "end": 4410.06, "word": " لازم", "probability": 0.95068359375}, {"start": 4410.06, "end": 4410.62, "word": " تكون", "probability": 0.98193359375}, {"start": 4410.62, "end": 4412.08, "word": " تظامن", "probability": 0.7117919921875}, {"start": 4412.08, "end": 4413.5, "word": " X", "probability": 0.134033203125}, {"start": 4413.5, "end": 4413.92, "word": "-linked", "probability": 0.6995442708333334}, {"start": 4413.92, "end": 4414.3, "word": " dominant", "probability": 0.80810546875}, {"start": 4414.3, "end": 4415.84, "word": " فالأم", "probability": 0.9503173828125}, {"start": 4415.84, "end": 4416.04, "word": " في", "probability": 0.96875}, {"start": 4416.04, "end": 4416.46, "word": " الحالة", "probability": 0.9454752604166666}, {"start": 4416.46, "end": 4416.74, "word": " هذه", "probability": 0.9521484375}, {"start": 4416.74, "end": 4417.38, "word": " مستحيل", "probability": 0.9659423828125}, {"start": 4417.38, "end": 4418.44, "word": " تكون", "probability": 0.98291015625}, {"start": 4418.44, "end": 4419.8, "word": " homozygous", "probability": 0.85439453125}, {"start": 4419.8, "end": 4420.16, "word": " للـ", "probability": 0.6361083984375}, {"start": 4420.16, "end": 4421.24, "word": " Two", "probability": 0.1883544921875}, {"start": 4421.24, "end": 4421.66, "word": " copies", "probability": 0.77392578125}, {"start": 4421.66, "end": 4422.0, "word": " تكون", "probability": 0.914306640625}, {"start": 4422.0, "end": 4422.64, "word": " مصابات", "probability": 0.841064453125}, {"start": 4422.64, "end": 4423.5, "word": " لأنه", "probability": 0.7051595052083334}, {"start": 4423.5, "end": 4423.9, "word": " فيه", "probability": 0.60546875}, {"start": 4423.9, "end": 4424.08, "word": " من", "probability": 0.98486328125}, {"start": 4424.08, "end": 4424.76, "word": " بناتها", "probability": 0.9251708984375}, {"start": 4424.76, "end": 4425.68, "word": " فيه", "probability": 0.760498046875}, {"start": 4425.68, "end": 4426.16, "word": " مصابات", "probability": 0.9923095703125}, {"start": 4426.16, "end": 4426.38, "word": " وفيه", "probability": 0.8474934895833334}, {"start": 4426.38, "end": 4427.24, "word": " طبيعيات", "probability": 0.98876953125}, {"start": 4427.24, "end": 4428.72, "word": " ماشي", "probability": 0.7657877604166666}, {"start": 4428.72, "end": 4430.3, "word": " ففيه", "probability": 0.806640625}, {"start": 4430.3, "end": 4430.8, "word": " مصابات", "probability": 0.995849609375}, {"start": 4430.8, "end": 4431.06, "word": " وفيه", "probability": 0.9456380208333334}, {"start": 4431.06, "end": 4431.8, "word": " طبيعيات", "probability": 0.97939453125}], "temperature": 1.0}, {"id": 165, "seek": 446033, "start": 4434.29, "end": 4460.33, "text": "فهذه ممكنة وهذه تحدث ويجب أن يكون الواحد ينتبه لها ويدرسها الموضوع هذه الفكرة مرة ثالثة أو مرة رابعة أو خامسة لما تشوف كل جيل فيه إصابات هذا الواضح ماشي، مافيش skip generation، هذه ناحية، الناحية الثانية", "tokens": [5172, 3224, 24192, 3714, 43020, 3660, 37037, 24192, 6055, 24401, 12984, 4032, 1829, 7435, 3555, 14739, 7251, 30544, 2423, 14407, 24401, 7251, 29399, 3555, 3224, 5296, 11296, 4032, 25708, 2288, 3794, 11296, 9673, 2407, 11242, 45367, 29538, 27188, 4117, 25720, 3714, 25720, 38637, 6027, 12984, 3660, 34051, 3714, 25720, 12602, 16758, 27884, 34051, 16490, 10943, 3794, 3660, 5296, 15042, 6055, 8592, 38688, 28242, 10874, 26895, 8978, 3224, 11933, 9381, 16758, 9307, 23758, 2423, 2407, 46958, 5016, 3714, 33599, 1829, 12399, 19446, 41185, 8592, 10023, 5125, 12399, 29538, 8717, 39319, 10632, 12399, 28239, 39319, 10632, 6024, 104, 7649, 10632], "avg_logprob": -0.3585858646065298, "compression_ratio": 1.7115384615384615, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 4434.29, "end": 4435.29, "word": "فهذه", "probability": 0.65283203125}, {"start": 4435.29, "end": 4435.97, "word": " ممكنة", "probability": 0.57763671875}, {"start": 4435.97, "end": 4436.65, "word": " وهذه", "probability": 0.521240234375}, {"start": 4436.65, "end": 4437.37, "word": " تحدث", "probability": 0.7718098958333334}, {"start": 4437.37, "end": 4438.89, "word": " ويجب", "probability": 0.589111328125}, {"start": 4438.89, "end": 4438.97, "word": " أن", "probability": 0.404052734375}, {"start": 4438.97, "end": 4439.01, "word": " يكون", "probability": 0.61474609375}, {"start": 4439.01, "end": 4439.33, "word": " الواحد", "probability": 0.61572265625}, {"start": 4439.33, "end": 4439.91, "word": " ينتبه", "probability": 0.918212890625}, {"start": 4439.91, "end": 4440.37, "word": " لها", "probability": 0.636962890625}, {"start": 4440.37, "end": 4443.91, "word": " ويدرسها", "probability": 0.6888671875}, {"start": 4443.91, "end": 4444.77, "word": " الموضوع", "probability": 0.81304931640625}, {"start": 4444.77, "end": 4445.21, "word": " هذه", "probability": 0.472900390625}, {"start": 4445.21, "end": 4446.45, "word": " الفكرة", "probability": 0.98486328125}, {"start": 4446.45, "end": 4446.73, "word": " مرة", "probability": 0.86865234375}, {"start": 4446.73, "end": 4447.69, "word": " ثالثة", "probability": 0.9853515625}, {"start": 4447.69, "end": 4448.05, "word": " أو", "probability": 0.9658203125}, {"start": 4448.05, "end": 4448.45, "word": " مرة", "probability": 0.890625}, {"start": 4448.45, "end": 4449.17, "word": " رابعة", "probability": 0.958984375}, {"start": 4449.17, "end": 4449.29, "word": " أو", "probability": 0.982421875}, {"start": 4449.29, "end": 4450.25, "word": " خامسة", "probability": 0.9189453125}, {"start": 4450.25, "end": 4450.49, "word": " لما", "probability": 0.6279296875}, {"start": 4450.49, "end": 4450.99, "word": " تشوف", "probability": 0.9744466145833334}, {"start": 4450.99, "end": 4451.41, "word": " كل", "probability": 0.7802734375}, {"start": 4451.41, "end": 4451.75, "word": " جيل", "probability": 0.6214599609375}, {"start": 4451.75, "end": 4452.57, "word": " فيه", "probability": 0.4827880859375}, {"start": 4452.57, "end": 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4489.48, "text": "واضح هنا إن الـ Females هم اللي affected والـ Males normal يعني هنا Normal Male وهنا Career Male تعتبروه أو Hemizygous للمل مش مؤثر عليه فيعني هذه X-linked dominant في الحالة هذه", "tokens": [2407, 46958, 5016, 34105, 36145, 2423, 39184, 479, 443, 4229, 8032, 2304, 13672, 1829, 8028, 16070, 39184, 376, 4229, 2710, 37495, 22653, 34105, 21277, 21080, 37037, 8315, 31690, 21080, 6055, 34268, 26890, 2407, 3224, 34051, 18568, 590, 18103, 563, 5296, 19528, 1211, 37893, 3714, 33604, 49115, 47356, 6156, 40228, 22653, 29538, 1783, 12, 22473, 292, 15657, 8978, 21542, 6027, 3660, 29538], "avg_logprob": -0.4075100676667306, "compression_ratio": 1.3825136612021858, "no_speech_prob": 0.0, "words": [{"start": 4460.62, "end": 4461.14, "word": "واضح", "probability": 0.9451497395833334}, {"start": 4461.14, "end": 4461.54, "word": " هنا", "probability": 0.88818359375}, {"start": 4461.54, "end": 4461.84, "word": " إن", "probability": 0.52294921875}, {"start": 4461.84, "end": 4462.0, 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"word": " الفكرة", "probability": 0.8238932291666666}, {"start": 5624.78, "end": 5624.92, "word": " اللي", "probability": 0.984375}, {"start": 5624.92, "end": 5625.12, "word": " بدي", "probability": 0.5125732421875}, {"start": 5625.12, "end": 5625.66, "word": " بقولولك", "probability": 0.650146484375}, {"start": 5625.66, "end": 5626.18, "word": " إياها", "probability": 0.9365234375}, {"start": 5626.18, "end": 5627.22, "word": " إنه", "probability": 0.742919921875}, {"start": 5627.22, "end": 5627.5, "word": " أنا", "probability": 0.85009765625}, {"start": 5627.5, "end": 5628.0, "word": " ممكن", "probability": 0.992431640625}, {"start": 5628.0, "end": 5630.26, "word": " تجيني", "probability": 0.8997802734375}, {"start": 5630.26, "end": 5630.58, "word": " إشي", "probability": 0.9405924479166666}, {"start": 5630.58, "end": 5630.84, "word": " زي", "probability": 0.992431640625}, {"start": 5630.84, "end": 5631.28, "word": " هيك", "probability": 0.66650390625}, {"start": 5631.28, "end": 5632.38, "word": " بقول", "probability": 0.8857421875}, {"start": 5632.38, "end": 5632.9, "word": " Hi", "probability": 0.289306640625}, {"start": 5632.9, "end": 5633.24, "word": " بما", "probability": 0.79736328125}, {"start": 5633.24, "end": 5633.56, "word": " إنه", "probability": 0.6904296875}, {"start": 5633.56, "end": 5634.06, "word": " سائد", "probability": 0.9319661458333334}, {"start": 5634.06, "end": 5634.26, "word": " و", "probability": 0.6171875}, {"start": 5634.26, "end": 5634.38, "word": " أنا", "probability": 0.4951171875}, {"start": 5634.38, "end": 5634.7, "word": " عارف", "probability": 0.9918619791666666}, {"start": 5634.7, "end": 5634.96, "word": " إنه", "probability": 0.967529296875}, {"start": 5634.96, "end": 5635.44, "word": " سائد", "probability": 0.9933268229166666}], "temperature": 1.0}, {"id": 210, "seek": 566212, "start": 5635.56, "end": 5662.12, "text": "إذا الأب لازم كان يكون مصاب فإذا أنا دورت بشكل سطحي وسريع وبالـ blood بس بلاقي إنه مثلا ممكن مايلاقيش إشي وبالتالي أدخل في مشكلة عشان بدي أحاول أفسر بينما لو أخدت منه من الـ testicle tissue ولا cells أو أخدت الـ sperms تبعينه ودرستهم", "tokens": [28814, 15730, 16247, 3555, 5296, 31377, 2304, 25961, 7251, 30544, 3714, 9381, 16758, 6156, 28814, 15730, 41850, 11778, 13063, 2655, 4724, 8592, 28820, 8608, 9566, 5016, 1829, 46952, 16572, 3615, 46599, 6027, 39184, 3390, 4724, 3794, 4724, 15040, 38436, 36145, 3224, 50113, 15040, 3714, 43020, 19446, 1829, 15040, 38436, 8592, 11933, 8592, 1829, 46599, 6027, 2655, 6027, 1829, 5551, 3215, 9778, 1211, 8978, 37893, 28820, 3660, 6225, 8592, 7649, 4724, 16254, 5551, 5016, 995, 12610, 5551, 36178, 2288, 49374, 15042, 45164, 5551, 9778, 3215, 2655, 9154, 3224, 9154, 2423, 39184, 1500, 3520, 12404, 49429, 5438, 34051, 5551, 9778, 3215, 2655, 2423, 39184, 24152, 2592, 6055, 3555, 3615, 9957, 3224, 4032, 3215, 2288, 14851, 16095], "avg_logprob": -0.1337635936944381, "compression_ratio": 1.6401673640167365, "no_speech_prob": 4.172325134277344e-07, "words": 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{"start": 5643.54, "end": 5644.06, "word": " وبالـ", "probability": 0.8011067708333334}, {"start": 5644.06, "end": 5644.36, "word": " blood", "probability": 0.227294921875}, {"start": 5644.36, "end": 5644.94, "word": " بس", "probability": 0.9384765625}, {"start": 5644.94, "end": 5646.16, "word": " بلاقي", "probability": 0.955078125}, {"start": 5646.16, "end": 5646.54, "word": " إنه", "probability": 0.72412109375}, {"start": 5646.54, "end": 5646.8, "word": " مثلا", "probability": 0.918701171875}, {"start": 5646.8, "end": 5647.26, "word": " ممكن", "probability": 0.931396484375}, {"start": 5647.26, "end": 5647.98, "word": " مايلاقيش", "probability": 0.85869140625}, {"start": 5647.98, "end": 5648.3, "word": " إشي", "probability": 0.9127604166666666}, {"start": 5648.3, "end": 5648.98, "word": " وبالتالي", "probability": 0.91572265625}, {"start": 5648.98, "end": 5649.48, "word": " أدخل", "probability": 0.98583984375}, {"start": 5649.48, "end": 5649.6, "word": " في", "probability": 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"probability": 0.6490478515625}, {"start": 5655.46, "end": 5656.68, "word": " tissue", "probability": 0.43212890625}, {"start": 5656.68, "end": 5657.62, "word": " ولا", "probability": 0.37939453125}, {"start": 5657.62, "end": 5658.3, "word": " cells", "probability": 0.85302734375}, {"start": 5658.3, "end": 5659.02, "word": " أو", "probability": 0.9658203125}, {"start": 5659.02, "end": 5659.38, "word": " أخدت", "probability": 0.9906005859375}, {"start": 5659.38, "end": 5659.54, "word": " الـ", "probability": 0.865966796875}, {"start": 5659.54, "end": 5660.02, "word": " sperms", "probability": 0.606201171875}, {"start": 5660.02, "end": 5660.78, "word": " تبعينه", "probability": 0.93857421875}, {"start": 5660.78, "end": 5662.12, "word": " ودرستهم", "probability": 0.9869140625}], "temperature": 1.0}, {"id": 211, "seek": 568981, "start": 5662.69, "end": 5689.81, "text": "بلاقي فعلًا وقتها الـ mutation موجودة فاهم عليك كده؟ فهذه النقطة اللي بدنا نذكرها هنا أنه أحيانًا أنه يعني الأمر متظامن الـ dominant و الـ recessive و الـ X-linked و الـ dominant و الـ recessive كل هذه الظواهر هي بشكل عام مبدأي فما نقعدي أخد individual families individual", "tokens": [3555, 15040, 38436, 6156, 30241, 14111, 995, 4032, 38149, 11296, 2423, 39184, 27960, 3714, 29245, 23328, 3660, 6156, 995, 16095, 25894, 4117, 9122, 3215, 3224, 22807, 6156, 3224, 24192, 28239, 47432, 3660, 13672, 1829, 47525, 8315, 8717, 8848, 37983, 11296, 34105, 14739, 3224, 5551, 5016, 1829, 7649, 14111, 995, 14739, 3224, 37495, 22653, 16247, 29973, 44650, 19913, 10943, 1863, 2423, 39184, 15657, 4032, 2423, 39184, 16417, 488, 4032, 2423, 39184, 1783, 12, 22473, 292, 4032, 2423, 39184, 15657, 4032, 2423, 39184, 16417, 488, 28242, 29538, 6024, 116, 14407, 3224, 2288, 39896, 4724, 8592, 28820, 6225, 10943, 3714, 44510, 10721, 1829, 6156, 15042, 8717, 4587, 22488, 1829, 5551, 9778, 3215, 2609, 4466, 2609], "avg_logprob": -0.2201327454727308, "compression_ratio": 1.676, "no_speech_prob": 1.1920928955078125e-07, "words": 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و", "probability": 0.57958984375}, {"start": 5675.15, "end": 5676.25, "word": " الـ", "probability": 0.5645751953125}, {"start": 5676.25, "end": 5677.41, "word": " recessive", "probability": 0.901611328125}, {"start": 5677.41, "end": 5677.73, "word": " و", "probability": 0.91064453125}, {"start": 5677.73, "end": 5677.89, "word": " الـ", "probability": 0.696533203125}, {"start": 5677.89, "end": 5678.15, "word": " X", "probability": 0.58154296875}, {"start": 5678.15, "end": 5678.73, "word": "-linked", "probability": 0.79833984375}, {"start": 5678.73, "end": 5678.89, "word": " و", "probability": 0.74462890625}, {"start": 5678.89, "end": 5679.29, "word": " الـ", "probability": 0.942138671875}, {"start": 5679.29, "end": 5679.81, "word": " dominant", "probability": 0.96435546875}, {"start": 5679.81, "end": 5680.09, "word": " و", "probability": 0.97802734375}, {"start": 5680.09, "end": 5680.15, "word": " الـ", "probability": 0.7568359375}, {"start": 5680.15, "end": 5681.11, "word": " recessive", "probability": 0.985107421875}, {"start": 5681.11, "end": 5681.37, "word": " كل", "probability": 0.732421875}, {"start": 5681.37, "end": 5681.61, "word": " هذه", "probability": 0.91748046875}, {"start": 5681.61, "end": 5682.61, "word": " الظواهر", "probability": 0.98515625}, {"start": 5682.61, "end": 5683.21, "word": " هي", "probability": 0.66748046875}, {"start": 5683.21, "end": 5684.21, "word": " بشكل", "probability": 0.9611002604166666}, {"start": 5684.21, "end": 5684.85, "word": " عام", "probability": 0.995849609375}, {"start": 5684.85, "end": 5685.45, "word": " مبدأي", "probability": 0.85205078125}, {"start": 5685.45, "end": 5685.99, "word": " فما", "probability": 0.22100830078125}, {"start": 5685.99, "end": 5686.47, "word": " نقعدي", "probability": 0.70391845703125}, {"start": 5686.47, "end": 5686.99, "word": " أخد", "probability": 0.8251953125}, {"start": 5686.99, "end": 5687.61, "word": " individual", "probability": 0.697265625}, {"start": 5687.61, "end": 5688.83, "word": " families", "probability": 0.94677734375}, {"start": 5688.83, "end": 5689.81, "word": " individual", "probability": 0.82373046875}], "temperature": 1.0}, {"id": 212, "seek": 571779, "start": 5691.81, "end": 5717.79, "text": "يعني كاسد بدي أكون حذر أكتر أنه ما تكون صارت أنتي شغل زي هيه أن بعض خلايا الإنسان هذا طبيعية وبعضهم mutated فحسب إذا ال mutation هذه في ال testicles وفي ال ovaries رح ينتج عنها أنه أنا ممكن مالاقيش الاشي اللي بدور عليه فمعليك", "tokens": [40228, 22653, 9122, 32277, 3215, 4724, 16254, 5551, 30544, 11331, 8848, 2288, 5551, 4117, 2655, 2288, 14739, 3224, 19446, 6055, 30544, 20328, 9640, 2655, 14739, 31371, 13412, 17082, 1211, 30767, 1829, 39896, 3224, 14739, 45030, 11242, 16490, 15040, 25528, 33688, 1863, 3794, 7649, 23758, 23032, 21292, 3615, 10632, 46599, 3615, 11242, 16095, 5839, 770, 6156, 5016, 35457, 11933, 15730, 2423, 27960, 29538, 8978, 2423, 1500, 5350, 4032, 41185, 2423, 14187, 4889, 12602, 5016, 7251, 29399, 7435, 18871, 11296, 14739, 3224, 41850, 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ecLGirzn8pc.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ecLGirzn8pc.srt
new file mode 100644
index 0000000000000000000000000000000000000000..6286cb3e21aa7eba66f42c4b3afc6b9f1e16defa
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ecLGirzn8pc.srt
@@ -0,0 +1,4726 @@
+1
+00:00:00,000 --> 00:00:06,380
+إن شاء الله يعني كمعلومة للطلاب
+
+2
+00:00:06,380 --> 00:00:10,240
+إحنا إن شاء الله راح يكون جزء الأخير بنشوف آلية
+
+3
+00:00:10,240 --> 00:00:15,100
+كويسة نراجع فيها الأسئلة تبع الـUSMLE والـCAPLAN
+
+4
+00:00:15,100 --> 00:00:22,060
+والمرجع اللي هي نوع معين international على أساس
+
+5
+00:00:22,060 --> 00:00:28,680
+يعني هو هذا المعيار اللي نغطي فيه المادة إن شاء الله
+
+6
+00:00:28,680 --> 00:00:37,170
+نكون استوعبناها واستفدنا إن شاء الله الآن،
+
+7
+00:00:37,170 --> 00:00:43,150
+نحن ماشيين لسه في الكتاب، ما ضلّ إلا فصل أو فصلين بعد
+
+8
+00:00:43,150 --> 00:00:51,130
+ذلك، يعني بالذات بعتبر الـEthics تبع الـGenetic
+
+9
+00:00:51,130 --> 00:00:55,690
+Counseling أو الشيء اللي بنعملها فيه جوانب أخلاقية
+
+10
+00:00:55,690 --> 00:01:00,500
+مهمة كثيرة، وهي أنا بعتبر مهمة من الواجب تناولها،
+
+11
+00:01:00,500 --> 00:01:06,280
+يعني هي بتظل محاضرة أو محاضرتين بعد اليوم وبعد ذلك
+
+12
+00:01:06,280 --> 00:01:14,500
+راح تكون نوع من مراجعة الأسئلة الآن
+
+13
+00:01:14,500 --> 00:01:20,640
+اليوم محاضرتين هما قريبتان على بعض وقصيرتان نوعًا ما
+
+14
+00:01:20,640 --> 00:01:24,040
+نتعامل
+
+15
+00:01:24,040 --> 00:01:31,660
+مع كيف بدنا نتعامل، يعني، ما هي الآليات؟ ما هي
+
+16
+00:01:31,660 --> 00:01:37,920
+الخطوات التي يجب أن تكون جهة معينة مسؤولة فيها
+
+17
+00:01:37,920 --> 00:01:44,700
+الحكومة، في البلد أو في مستشفى تتعامل مع كيف ننصح
+
+18
+00:01:44,700 --> 00:01:50,080
+الأهالي والعائلات لما نكون عندنا احتمالية أمراض
+
+19
+00:01:50,080 --> 00:01:56,800
+وراثية. الآن فيه Two Chapters Today فيه Risk
+
+20
+00:01:56,800 --> 00:02:00,440
+Assessment وGenetic Counseling يعني شو بدنا نعمل
+
+21
+00:02:00,440 --> 00:02:05,260
+في الموضوع هذا وبعد ذلك في المحاضرة اللي بعدها اللي
+
+22
+00:02:05,260 --> 00:02:11,380
+هي نسميها Preterm أو Prenatal Diagnosis اللي هو
+
+23
+00:02:11,380 --> 00:02:19,840
+تشخيص ما قبل الولادة، يعني حتى إذا في خيار أنه تعمل
+
+24
+00:02:19,840 --> 00:02:27,020
+علاجات معينة أنه نعملها. اليوم المحاضرة الأولى هي
+
+25
+00:02:27,020 --> 00:02:35,700
+على شو نعمل مع عائلة عندها احتمالية مرض وراثي، شو
+
+26
+00:02:35,700 --> 00:02:40,280
+ننصحها، كيف ننصحها، على أي أساس ننصحها، وكيف نتعامل
+
+27
+00:02:40,280 --> 00:02:45,100
+مع الموضوع هذا. النقطة
+
+28
+00:02:45,100 --> 00:02:55,240
+الأولى، يعني حاطين هنا ما يمثل قواعد عامة في التعامل
+
+29
+00:02:55,240 --> 00:02:59,200
+مع الـGenetic Diseases
+
+30
+00:03:03,670 --> 00:03:08,170
+قسموا العائلة، يعني ممكن أي إنسان يكون عنده هيك
+
+31
+00:03:08,170 --> 00:03:12,830
+إذا بيشوف أحد من أقاربه عنده حالة وراثية، ممكن هو
+
+32
+00:03:12,830 --> 00:03:17,510
+يتساءل جوا نفسه إنه هل أنا معرض أو أصاب بنفس المرض
+
+33
+00:03:17,510 --> 00:03:24,670
+بنفس الطريقة، أو إذا عائلة أو زوجين عندهم واحد أو
+
+34
+00:03:24,670 --> 00:03:31,350
+في العائلة عندهم مرض معين، بتكون يعني الواحد
+
+35
+00:03:31,350 --> 00:03:36,550
+هيك بيقدر. هنا كقاعدة
+
+36
+00:03:36,550 --> 00:03:41,490
+عامة، خلّيني آخذ بالأخير، بالأول والآخر واحدة تحت
+
+37
+00:03:41,490 --> 00:03:46,890
+كتبيلكم الـAverage Risk الإنسان العادي، يعني إحنا
+
+38
+00:03:46,890 --> 00:03:50,890
+قررنا عن أمراض كثيرة، بيصير الواحد أصلاً مخّه يلفّ
+
+39
+00:03:50,890 --> 00:03:55,030
+ويفكّر إنه عنده واحد من هذه الأشياء أو ممكن يصيبه
+
+40
+00:03:55,030 --> 00:03:59,730
+أو ممكن يصيب ولاده ولا كده. الـAverage Risk اللي
+
+41
+00:03:59,730 --> 00:04:03,480
+هي زي الـRisk in the general population عندما يكون
+
+42
+00:04:03,480 --> 00:04:07,360
+هناك مصادر غير مصادر مصادر مصادر مصادر مصادر مصادر
+
+43
+00:04:07,360 --> 00:04:09,820
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+44
+00:04:09,820 --> 00:04:12,860
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+45
+00:04:12,860 --> 00:04:14,240
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+46
+00:04:14,240 --> 00:04:17,180
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+47
+00:04:17,180 --> 00:04:18,020
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+48
+00:04:18,020 --> 00:04:28,830
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر. يعني هذه
+
+49
+00:04:28,830 --> 00:04:34,830
+نفس المعنى، مش عارف ليش يعني بيحطّها تكرار بس
+
+50
+00:04:34,830 --> 00:04:39,790
+الاثنتين بتعني إنه واحد ما عنده مثل هذه الحالة لما تصل
+
+51
+00:04:39,790 --> 00:04:44,990
+الأمور إلى إنه second degree relative، يعني إنسان
+
+52
+00:04:44,990 --> 00:04:55,410
+ابن عم أو عم أو أحد أبعد شوية، وشخص واحد بس
+
+53
+00:04:55,410 --> 00:05:01,260
+يعني مش عدد أكبر، بكون هذه الاحتمالية تعتبر يعني مش
+
+54
+00:05:01,260 --> 00:05:04,760
+أكثر من الـGeneral Population بشكل عام، وهنشوف
+
+55
+00:05:04,760 --> 00:05:08,780
+أمثلة عليها، أو في حالة ما بيصير عملية تبنّي
+
+56
+00:05:08,780 --> 00:05:15,660
+فالإنسان المتبنى ما له علاقة بالـ، يعني، بما هو
+
+57
+00:05:15,660 --> 00:05:20,500
+معلوم عن العائلة من وجود أمراض وراثية. فهؤلاء
+
+58
+00:05:20,500 --> 00:05:25,960
+Average Risk. في المقابل الـ
+
+59
+00:05:27,710 --> 00:05:34,690
+عندنا الـgroup بتكون High Risk إذا كان عندنا First
+
+60
+00:05:34,690 --> 00:05:40,210
+degree relative قريب من الدرجة الأولى، وعرفناهم من
+
+61
+00:05:40,210 --> 00:05:45,310
+قبل، اللي هم يعني الأب والأم والإخوان والبنات
+
+62
+00:05:45,310 --> 00:05:50,250
+والبنات، لأي واحد حواليه أبعد من هيك بيصير Second
+
+63
+00:05:50,250 --> 00:05:56,230
+degree وأبعد من ذلك Third degree. فلما يكون الـ
+
+64
+00:05:56,230 --> 00:06:03,630
+First degree relative ماشي، وتكون Early، يعني بالذات
+
+65
+00:06:03,630 --> 00:06:09,670
+إذا المرض بيبين على عمره صغير، إذا في عندنا اثنين
+
+66
+00:06:09,670 --> 00:06:14,450
+Affected First degree relatives هذه High risk one
+
+67
+00:06:14,450 --> 00:06:18,710
+First degree relative with late or unknown disease
+
+68
+00:06:18,710 --> 00:06:24,770
+onset. وشخصين من الجامعة الأولى والأولى وشخصين من
+
+69
+00:06:24,770 --> 00:06:33,550
+الدرجة
+
+70
+00:06:33,550 --> 00:06:37,250
+الأولى والأولى وشخصين من الجامعة الأولى والأولى
+
+71
+00:06:37,250 --> 00:06:38,710
+وشخصين من الجامعة الأولى والأولى
+
+72
+00:06:38,710 --> 00:06:40,290
+وشخصين من الجامعة الأولى والأولى
+
+73
+00:06:40,290 --> 00:06:40,510
+وشخصين من الجامعة الأولى والأولى
+
+74
+00:06:40,510 --> 00:06:42,190
+وشخصين من الجامعة الأولى وشخصين من
+
+75
+00:06:42,190 --> 00:06:43,330
+الجامعة الأولى وشخصين من الجامعة الأولى وشخصين من
+
+76
+00:06:43,330 --> 00:06:43,770
+الجامعة الأولى وشخصين من الجامعة الأولى وشخصين من
+
+77
+00:06:43,770 --> 00:06:45,110
+الجامعة الأولى وشخصين من الجامعة الأولى وشخص. ثلاثة
+
+78
+00:06:45,110 --> 00:06:47,710
+أو أكثر مصادر أو مصادر أساسي أو مصادر أساسي أو
+
+79
+00:06:47,710 --> 00:06:49,930
+مصادر أساسي أو مصادر أساسي أو مصادر أساسي أو مصادر
+
+80
+00:06:49,930 --> 00:06:51,010
+أساسي أو مصادر أساسي أو مصادر أساسي أو مصادر أساسي
+
+81
+00:06:51,010 --> 00:06:54,070
+أو مصادر أساسي أو مصادر أساسي أو مصادر أساسي أو
+
+82
+00:06:54,070 --> 00:06:58,950
+مصادر أساسي أو مصادر أساسي أو مصادر أساسي أو مصادر
+
+83
+00:06:58,950 --> 00:06:59,970
+أساسي أو مصادر أساسي أو مصادر أساسي أو مصادر أساسي
+
+84
+00:06:59,970 --> 00:07:05,250
+أو مصادر أساسي أو مصادر أساسي أو مصادر أساسي أو
+
+85
+00:07:05,250 --> 00:07:17,470
+مصادر أساسي أو مصادر. ماشي، يعني بيكون الاحتمالية
+
+86
+00:07:17,470 --> 00:07:23,450
+أكبر، وخطورة حدوث مرض وراثي أعلى جداً في حالة وجود
+
+87
+00:07:23,450 --> 00:07:30,000
+أي من هذه الحالات. من بين، متوسط، Moderate risk يكون
+
+88
+00:07:30,000 --> 00:07:33,940
+One First degree relative with late or unknown
+
+89
+00:07:33,940 --> 00:07:36,960
+onset of disease أو Two second degree relative
+
+90
+00:07:36,960 --> 00:07:40,020
+from the same lineage with late or unknown disease
+
+91
+00:07:40,020 --> 00:07:47,020
+onset. يعني هنا الفكرة، كل ما كانت درجة القرابة أقرب
+
+92
+00:07:47,020 --> 00:07:51,530
+First degree مقارنة بـSecond أو Third degree وكل ما
+
+93
+00:07:51,530 --> 00:07:57,950
+كان العمر أقل أو أصغر في بداية المرض بيكون
+
+94
+00:07:57,950 --> 00:08:02,490
+احتمالية العامل الوراثي أكبر، وهذه حتى إحنا شفناها
+
+95
+00:08:02,490 --> 00:08:09,450
+بالنسبة لمقارنة الـChromosome مع الـSingle Gene
+
+96
+00:08:09,450 --> 00:08:16,480
+Disease، اللي هي المجموعة الثالثة، الـPolygenic أو
+
+97
+00:08:16,480 --> 00:08:20,900
+Multifactorial Diseases، بيصير كل ما كبر الإنسان في
+
+98
+00:08:20,900 --> 00:08:24,420
+العمر، الـMultifactorial هم اللي أكثر، والـrole أو
+
+99
+00:08:24,420 --> 00:08:30,500
+الحجم تبع الـGenetic Diseases importance بيصير
+
+100
+00:08:30,500 --> 00:08:38,010
+أقل، أقل مع تقدم العمر. هذه مبدأ أو شيء يجب أن
+
+101
+00:08:38,010 --> 00:08:45,750
+يحكمنا ويجب أن نكون منتبهين له، لأنه يجب أن يكون في
+
+102
+00:08:45,750 --> 00:08:51,030
+أي مكان، نفترض في غزة ولا كذا، المفروض أن يكون شخص
+
+103
+00:08:51,030 --> 00:08:57,890
+متخصص بالأمراض الوراثية، وهو نوع من التخصصات غريب
+
+104
+00:08:57,890 --> 00:09:05,590
+قليلاً. في مرات كثيرة أطباء أطفال يتخصصوا بمثل هذا
+
+105
+00:09:05,590 --> 00:09:12,070
+التخصص، و يأخذون تدريب خاص منه على الـGenetics، ومنه
+
+106
+00:09:12,070 --> 00:09:16,890
+على الكلام اللي راح نحكيه، كيف الواحد يعمل عملية
+
+107
+00:09:16,890 --> 00:09:20,350
+الـCounseling، كيف الواحد يقود العائلة بالنسبة
+
+108
+00:09:20,350 --> 00:09:29,630
+للتعامل مع حالة مرض وراثي. الآن لما نيجي نشوف مين
+
+109
+00:09:31,950 --> 00:09:38,830
+الناس اللي يعني يسعون أن يطلبوا الـGenetic
+
+110
+00:09:38,830 --> 00:09:44,150
+Counseling، وبتلاقي يعني الـCommon Indications for
+
+111
+00:09:44,150 --> 00:09:49,470
+Genetic Counseling اللي بحتاج هذا الأمر، ماشي هم
+
+112
+00:09:49,470 --> 00:09:57,030
+مجموعة، يعني مش كل الـpopulation عادةً يعني بتهم هذا
+
+113
+00:09:57,030 --> 00:10:05,110
+الموضوع. مرات بتلاقي يعني في حدث
+
+114
+00:10:05,110 --> 00:10:09,990
+معيّن أو شيء معيّن صار في عائلة معينة، بالتالي
+
+115
+00:10:09,990 --> 00:10:17,850
+بتخليهم يسعون أن يحاولوا يدرسوا كم نسبة احتمالية
+
+116
+00:10:17,850 --> 00:10:23,350
+حدوث المرض الوراثي مرة أخرى، أو يطلبون الـ
+
+117
+00:10:23,350 --> 00:10:27,540
+Counseling. إذا كان عائلة عندهم previous child with
+
+118
+00:10:27,540 --> 00:10:30,140
+multiple congenital anomalies أو intellectual
+
+119
+00:10:30,140 --> 00:10:34,640
+disabilities أو isolated birth defect أو cleft lip
+
+120
+00:10:34,640 --> 00:10:41,260
+و cleft palate، يعني شخص عائلة عندها فرد مصاب بمرض
+
+121
+00:10:41,260 --> 00:10:48,140
+وراثي أو احتمال أن يكون وراثياً. هنا بيصير فيه اهتمام
+
+122
+00:10:48,140 --> 00:10:52,840
+إنّه طبّ، والأطفال اللي بعد ذلك، هيصيبهم، مش هيصيبهم،
+
+123
+00:10:52,840 --> 00:10:56,900
+ومش هي احتمالية؟ يعني في مرات ناس بيقول لك خلاص،
+
+124
+00:10:56,900 --> 00:11:03,030
+بقطع الخلف وما بدّيش أمر في معاناة طفل مصاب، ويعني دا
+
+125
+00:11:03,030 --> 00:11:09,430
+احتمالية صعبة شديدة إنه يكون يتوفى ولا كده. إنما
+
+126
+00:11:09,430 --> 00:11:16,570
+يكون في شخص مصاب في العائلة already بتلاقي يعني
+
+127
+00:11:16,570 --> 00:11:21,490
+بيكون فيه اهتمام إنه يسعوا لحصول على الاستشارة
+
+128
+00:11:21,490 --> 00:11:25,310
+الوراثية. إذا في Personal history أو Family history
+
+129
+00:11:25,310 --> 00:11:29,100
+وHereditary condition مثل الـCystic Fibrosis أو
+
+130
+00:11:29,100 --> 00:11:30,940
+الـFragile X Syndrome أو الـCongenital Heart
+
+131
+00:11:30,940 --> 00:11:34,100
+Disease أو الـHereditary Cancer من أنواع الـ
+
+132
+00:11:34,100 --> 00:11:38,440
+cancers اللي لها ارتباط بالعائلة. حكينا عن الـ
+
+133
+00:11:38,440 --> 00:11:42,340
+Retinoblastoma أو الـFamily الـHereditary
+
+134
+00:11:42,340 --> 00:11:47,500
+Polyposis أو الـColi أو فيه أشياء معينة، السكري
+
+135
+00:11:47,500 --> 00:11:52,580
+أحياناً. إذا في شخص نفسه أو العائلة عنده مرض معين
+
+136
+00:11:52,920 --> 00:11:58,020
+بتلاقي الأعضاء الآخرين بيهمهم إنه يشوفوا عندهم نفس
+
+137
+00:11:58,020 --> 00:12:02,360
+الخطورة
+
+138
+00:12:02,360 --> 00:12:09,720
+نفس الطريقة ولا لأ. في حالة إذا كان عائلة عندهم
+
+139
+00:12:09,720 --> 00:12:15,240
+Chromosomal أو Hereditary disorder ويكون المرأة
+
+140
+00:12:15,240 --> 00:12:20,920
+حامل في هذا الوقت بتلاقي بيصير هيك قلق وبيصير
+
+141
+00:12:20,920 --> 00:12:25,800
+anxiety إنه هل هيصير شيء ولا مش هيصير شيء. في حالات
+
+142
+00:12:25,800 --> 00:12:29,720
+الـPregnancy لشخص
+
+143
+00:12:29,720 --> 00:12:36,460
+أو عائلة عندهم معروف إنه فيه أمراض كروموزومية أو
+
+144
+00:12:36,460 --> 00:12:41,400
+وراثية. في حالة الـConsanguinity، يعني هذا الجانب
+
+145
+00:12:41,400 --> 00:12:46,700
+عندنا طبعاً يعني في ثقافات أمم أخرى. الـ
+
+146
+00:12:46,700 --> 00:12:55,000
+Consanguinity، يعني أنا متأكد أو بعرف، في مثلًا في
+
+147
+00:12:55,000 --> 00:13:00,540
+ثقافات أخرى مثلًا الروس، بنت العم وابن العم هؤلاء
+
+148
+00:13:00,540 --> 00:13:05,560
+زي الإخوة والأخوات، يعني ما بيتزوجوا، ما بيعرفوا على
+
+149
+00:13:05,560 --> 00:13:11,240
+بعض يعني. فـعندنا الـConsanguinity في ثقافتنا أكبر، بس
+
+150
+00:13:11,240 --> 00:13:15,020
+على مستوى أبعد شوية، مش First degree أو Second
+
+151
+00:13:15,020 --> 00:13:18,720
+degree يعني، أو Very strong consanguinity موجودة
+
+152
+00:13:18,720 --> 00:13:23,400
+بتلاقي احتمالية تكون موجودة. في حالات الـTeratogen
+
+153
+00:13:23,400 --> 00:13:30,360
+exposure، يعني إذا كان شيء معروف إنه بيعمل مشكلة
+
+154
+00:13:30,360 --> 00:13:38,220
+وصار الـexposure، ممكن العائلة تهتم إنها تفهم هل في
+
+155
+00:13:38,220 --> 00:13:45,920
+احتمالية أن يكون شيء Genetic ولا لأ؟ راح نأخذ يعني
+
+156
+00:13:45,920 --> 00:13:52,400
+هنا كلمة Teratogen هي مرتبطة بالشيء لما نقول
+
+157
+00:13:52,400 --> 00:13:56,120
+الـCongenital Anomalies، الـCongenital يعني خلقي
+
+158
+00:13:56,120 --> 00:14:04,300
+يعني شيء الطفل لما يولد بيبين معه وكان بيبين معه
+
+159
+00:14:04,300 --> 00:14:10,150
+فإذا شيء حدث في الرحم، يعني. مرات مش كل Congenital
+
+160
+00:14:10,150 --> 00:14:14,250
+معناته Genetic، يعني هي لا تساوي هذه. Congenital
+
+161
+00:14:14,250 --> 00:14:20,990
+يعني في الحمل، في خلال فترة الحمل، واللي يكون
+
+162
+00:14:20,990 --> 00:14:26,180
+الإنسان جنيناً. يمكن أن يكون Congenital مثلًا «توكسوبلازموسيس» Congenital «روبيلا» مثلًا الحصبة
+
+163
+00:14:26,180 --> 00:14:32,140
+الألمانية، أو «توكسوبلازموسيس» بيجي من الـ«بيساس»
+
+164
+00:14:32,140 --> 00:14:36,300
+فممكن يعمل التهابات أو مرض في الجنين من خلال إصابة
+
+165
+00:14:36,300 --> 00:14:42,060
+الأم بهذا الشيء. فأحياناً الـ«تيراتوجين» يعني هو
+
+166
+00:14:42,060 --> 00:14:46,320
+بالأخير هيكون شيء خلقي، يعني سيولد الإنسان فيه، لكن
+
+167
+00:14:46,320 --> 00:14:50,610
+ليس بالضرورة جينيّاً. بس التعامل بينهم قريب كذلك
+
+168
+00:14:50,610 --> 00:14:55,650
+العائلات اللي عندهم repeated pregnancy loss أو
+
+169
+00:14:59,950 --> 00:15:03,470
+infertility هذه برضه من الأشياء اللي بتصير ندوّر
+
+170
+00:15:03,470 --> 00:15:08,230
+على Chromosomal anomalies أو unemployed دي
+
+171
+00:15:08,230 --> 00:15:12,510
+والأشياء اللي زي هيك. فلما نكون في عائلة أو couple
+
+172
+00:15:13,440 --> 00:15:20,060
+زوجين في عندهم مشكلة في عقم وعدم خلفة ممكن أو
+
+173
+00:15:20,060 --> 00:15:23,980
+repeat pregnancy loss، طبعاً ممكن يكون أمراض أخرى
+
+174
+00:15:23,980 --> 00:15:30,620
+بس هذه برضه بتكون من الأشياء اللي بيصير عندنا اهتمام
+
+175
+00:15:30,620 --> 00:15:37,000
+يعني اهتمام بالحصول على الاستشارة الوراثية. Newly
+
+176
+00:15:37,000 --> 00:15:41,030
+diagnosed anomaly or genetic condition. هذه برضه
+
+177
+00:15:41,030 --> 00:15:47,410
+ناحية مهمة. عادةً، عادةً حتى في عائلة الكل بيخبر بعض
+
+178
+00:15:47,410 --> 00:15:55,430
+ف
+
+223
+00:19:47,850 --> 00:19:53,810
+لازم، ولازم الواحد يعني يفهم، يستوعب العائلة، ويستوعب
+
+224
+00:19:53,810 --> 00:19:57,290
+الإنسان اللي أمامه، المريض أو العائلة أو الأبوين
+
+225
+00:19:57,720 --> 00:20:03,980
+ويفهمهم كلامًا مفهومًا، ويتفق على آليات معينة. فالنقطة
+
+226
+00:20:03,980 --> 00:20:08,060
+الأخيرة، حكينا اللي هي as a follow-up for positive
+
+227
+00:20:08,060 --> 00:20:16,860
+result of a newborn test. ماشي، يعني هي الفكرة هنا
+
+228
+00:20:16,860 --> 00:20:22,600
+حاطين أنواع من الأشياء، الـtests اللي بتنعمل، النقاط
+
+229
+00:20:22,600 --> 00:20:34,410
+هنا عندنا مثلًا في الأردن، كل الأطفال عند أول تطعيم
+
+230
+00:20:34,410 --> 00:20:39,710
+بعد أسبوع أو خلال الفترة الأولى، من نقطة من القدم
+
+231
+00:20:39,710 --> 00:20:50,190
+على ورقة نشاف، بنشفوا نقطة الدم، وبعدها تُبعث للفحص
+
+232
+00:20:50,980 --> 00:20:55,920
+الـPhenylketonuria، والـThyroid، وحتى الـHIV أظن
+
+233
+00:20:55,920 --> 00:21:02,060
+بيعملوه روتين للكل، ماشي. فإيه ده؟ طبعًا كل هذه
+
+234
+00:21:02,060 --> 00:21:07,500
+الفحوصات، مش 100% الـsensitivity والـspecificity.
+
+235
+00:21:07,500 --> 00:21:11,620
+تبعتها، يعني لو positive ممكن تكون false positive.
+
+236
+00:21:11,620 --> 00:21:14,820
+لو negative ممكن كمان تكون false negative، يعني حتى
+
+237
+00:21:14,820 --> 00:21:20,160
+لو فحص ممتاز 99% بيجيبها صح، مافي إشي 100% في
+
+238
+00:21:20,160 --> 00:21:27,540
+الدنيا. يعني في أمراض معينة لو اجت لسبب، طلع نتيجة
+
+239
+00:21:27,540 --> 00:21:34,140
+إيجابية أو plus minus، يعني على الحافة، فكيف بدنا نفهم
+
+240
+00:21:34,140 --> 00:21:39,940
+العائلة هذا الموضوع؟ هي بدها إنه يصير genetic
+
+241
+00:21:39,940 --> 00:21:43,960
+counseling، الـ
+
+242
+00:21:44,840 --> 00:21:48,580
+أنا بحكي، أنا بتكلم، إذا حد عنده سؤال، يسأل. إذا
+
+243
+00:21:48,580 --> 00:21:54,880
+فيه إيش مش واضح، شو اسمه، احكولي، وخلينا بنوقف
+
+244
+00:21:54,880 --> 00:21:59,680
+وبنعيد، يعني، ماشي الحال؟ فدولة الـindications
+
+245
+00:21:59,680 --> 00:22:04,140
+for Genetic Counseling، دولة العادة، الحوادث، أو
+
+246
+00:22:04,140 --> 00:22:10,880
+القصص أو الأشياء اللي بتدفع بعض العائلات يطلبوا
+
+247
+00:22:10,880 --> 00:22:12,520
+الـGenetic Counseling.
+
+248
+00:22:15,080 --> 00:22:19,900
+لما يأتي الإنسان اللي هو الـCounselor، ما هو
+
+249
+00:22:19,900 --> 00:22:24,920
+المفروض أن يفعله؟ النقطة الأولى، يجب أن يقوم
+
+250
+00:22:24,920 --> 00:22:27,940
+بـCollection of Information، اللي هي الـFamily
+
+251
+00:22:27,940 --> 00:22:31,880
+History، الـMedical History، والـPrevious Tests
+
+252
+00:22:31,880 --> 00:22:35,440
+وAdditional Assessments. يعني كل هذه الجوانب، يجب
+
+253
+00:22:35,440 --> 00:22:41,920
+أن يجمعها ويرتبها مع بعض. الـFamily History، يمكن
+
+254
+00:22:41,920 --> 00:22:47,320
+من أهم شيء، أيه قضية اللي هي الـPedigree؟ ماشي،
+
+255
+00:22:47,320 --> 00:22:55,160
+فمين في العائلة مصاب، على أي عمر بدأت، شو علاقاتهم
+
+256
+00:22:55,160 --> 00:22:59,500
+ببعض، متأكد الواحد من المعلومة، مش متأكد، يجمع
+
+257
+00:22:59,500 --> 00:23:02,220
+المعلومات كلها. فأول شيء، Collection of
+
+258
+00:23:02,220 --> 00:23:06,640
+Information، هذه نقطة أساسية. بعدين لازم يفحص
+
+259
+00:23:06,640 --> 00:23:12,610
+المريض، ويشوف كل نتاجه، Physical Examination، عنده
+
+260
+00:23:12,610 --> 00:23:18,550
+ما عندهوش مثلًا، يعني والله أنا شُفت مثلًا إنسان
+
+261
+00:23:18,550 --> 00:23:25,130
+طويل وعنده high arch، بلد، وعنده، أنا فكرت أنه عنده
+
+262
+00:23:25,130 --> 00:23:29,250
+إيش بنسميه؟ «Marfan syndrome» ولا كذا، وإيكِ هذا
+
+263
+00:23:29,250 --> 00:23:33,270
+مرتبط مثلًا بـcongenital heart disease، فيمكن
+
+264
+00:23:33,270 --> 00:23:37,450
+المريض عنده «مرمر» وعنده مشكلة في القلب، ومريض فعلا
+
+265
+00:23:37,450 --> 00:23:41,280
+وعنده «congenital»، بس ما كانش حدا لأنه ما اشتكى،
+
+266
+00:23:41,280 --> 00:23:45,600
+ما حدش فحصه، فمش عارفين عن وجود أو عدم وجود جانب
+
+267
+00:23:45,600 --> 00:23:50,980
+معين. بعدين الـPhysical Examination، الـLaboratory
+
+268
+00:23:50,980 --> 00:23:54,180
+and Radiological Testing، وValidation or
+
+269
+00:23:54,180 --> 00:23:59,420
+Establishment of Diagnosis if possible، ماشي؟ يعني
+
+270
+00:23:59,420 --> 00:24:04,340
+بيجمع الواحد كمان كل النتائج، بما فيها الأشعات
+
+271
+00:24:04,340 --> 00:24:11,060
+السابقة، والنتائج تبعتها، والـValidation أو الـ
+
+272
+00:24:11,060 --> 00:24:14,280
+Establishment، بالذات فيه فرصات أدق على هذا الموضوع.
+
+273
+00:24:14,280 --> 00:24:23,820
+يعني إنسان عنده مثلًا، والله ضمور في العضلات، وخلل
+
+274
+00:24:23,820 --> 00:24:31,060
+في العضلات، لو كان الشغل هذه من الصغر ومن الطفولة
+
+275
+00:24:31,600 --> 00:24:36,040
+بتكون مرض معين، بس لو نفس المشكلة أو إشي شبيه فيها
+
+276
+00:24:36,040 --> 00:24:40,320
+على عمر أكبر، لأ، بتصير Becker disease بدل Duchenne
+
+277
+00:24:40,320 --> 00:24:46,200
+muscular dystrophy. فبتصير يعني التشخيص، على أي عمر
+
+278
+00:24:46,200 --> 00:24:50,540
+كانت. فحتى نتأكد أن المشكلة ما بدت بعمر أسبق،
+
+279
+00:24:50,540 --> 00:24:54,720
+فنشوف النتائج القديمة ونجمعها. الـCounseling
+
+280
+00:24:58,040 --> 00:25:02,040
+بتكلم الواحد على الـNature وConsequences of the
+
+281
+00:25:02,040 --> 00:25:10,160
+Disorder. يعني، ماذا يريد أن يشرح للذي أمامه؟ ما هو
+
+282
+00:25:10,160 --> 00:25:16,680
+المرض؟ وما هو طبيعته؟ وما هو نتاجه؟ بما فيها أرقام
+
+283
+00:25:16,680 --> 00:25:22,120
+واحتمالات، وكذلك الـRecurrence Risk، Availability
+
+284
+00:25:22,120 --> 00:25:28,540
+of Further or Future Testing. يعني مثلًا الـDown
+
+285
+00:25:28,540 --> 00:25:32,400
+Syndrome، الـDown Syndrome، ماشي، هو هذا الإنسان
+
+286
+00:25:32,400 --> 00:25:36,520
+عنده Down Syndrome، بس في نفس الوقت ممكن الـDown
+
+287
+00:25:36,520 --> 00:25:42,380
+Syndrome يكون mosaic، يعني الـTrisomy 21 مش في كل
+
+288
+00:25:42,380 --> 00:25:46,280
+الـcells، في نص الـcells، في تلت أرباع الـcells،
+
+289
+00:25:46,280 --> 00:25:50,420
+في عشرين بالمئة بالـcells، فبتصير درجات من هذه
+
+290
+00:25:50,420 --> 00:25:57,050
+الحالة، بالتالي بيكون يعني توقعنا بالنسبة لشو نعمل
+
+291
+00:25:57,050 --> 00:26:03,230
+أو شو درجتنا، شو يعني توقعنا عن المستقبل راح يكون
+
+292
+00:26:03,230 --> 00:26:08,470
+قراءتنا للمستقبل بتكون تختلف. بعدين الـdecision
+
+293
+00:26:08,470 --> 00:26:13,070
+making، شو القرارات اللي ممكن تتنفق عليها؟ referral
+
+294
+00:26:13,070 --> 00:26:16,470
+to other specialists، أو health agencies، أو support
+
+295
+00:26:16,470 --> 00:26:23,660
+groups. يعني مثلًا، أنا والله لقيت حالي عنده final
+
+296
+00:26:23,660 --> 00:26:30,620
+cataneuria، إذا يمكن الأهل والناس أولها بيصدموا، «شو
+
+297
+00:26:30,620 --> 00:26:35,240
+هالشغل؟» بخاف الواحد وكذا، بعدين بحكيله، «والله هاي
+
+298
+00:26:35,240 --> 00:26:38,960
+لا، والله الشغل شائع»، «في عنا جمعية بتقوم
+
+299
+00:26:38,960 --> 00:26:44,340
+بالرعاية هذه الحالات». إذا اتعامل الواحد مظبوط مع
+
+300
+00:26:44,340 --> 00:26:49,380
+المرض من الصغر، واكتشف مبكر، والعلاج والأكل مظبوط،
+
+301
+00:26:49,670 --> 00:26:53,110
+الطفل اللي بيعيش، أو الإنسان هذا، بيطلع طبيعي، ومافيش
+
+302
+00:26:53,110 --> 00:26:57,590
+معاه مشكلة. فبودّيه على الـSupport Groups، فيه
+
+303
+00:26:57,590 --> 00:27:03,090
+عيادات معينة، إنهم فيه جمعيات متخصصة بتعتني فيهم.
+
+304
+00:27:03,090 --> 00:27:08,970
+فيه كذا، فيه كذا، فكلّه بتصير الواحد يعطيهم يعني
+
+305
+00:27:08,970 --> 00:27:13,600
+يقودهم في أنه يتعاملوا مع المرض هذا. continuing
+
+306
+00:27:13,600 --> 00:27:16,440
+clinical assessment، especially if no diagnosis.
+
+307
+00:27:16,440 --> 00:27:20,480
+وطبعًا الـPsychosocial support، هذه نواحي مهمة
+
+308
+00:27:20,480 --> 00:27:24,000
+كثير. إن الواحد يظل يتابع، إذا واحد ما يعرفش إيش
+
+309
+00:27:24,000 --> 00:27:29,440
+يقول، ما يعرفش، مش متأكد، ما يفتي بثقة، يحكي بثقة
+
+310
+00:27:29,440 --> 00:27:39,720
+للي أمامه، هو يعني مش متأكد، بس في المقابل يعني من
+
+311
+00:27:39,720 --> 00:27:44,050
+أهم الجوانب، يعني بقدر حوالي ثلاثين بالمئة من تأثير
+
+312
+00:27:44,050 --> 00:27:50,630
+الطب، هو تأثير نفسي، يعني اللي بيسموه الـplacebo
+
+313
+00:27:50,630 --> 00:27:55,630
+effect. يعني كثير من مثلًا، بيكون بطن الواحد بوجعه،
+
+314
+00:27:55,630 --> 00:28:00,130
+وفي لحظة ما بيبدأ يدخل على المستشفى، بيكون بيصرخ و
+
+315
+00:28:00,130 --> 00:28:05,190
+بعيط وكده، بس لسه بده يدخل على باب الطوارئ، بيدلاق
+
+316
+00:28:05,190 --> 00:28:11,170
+الألم خارج. وهذه ظاهرة كلّها بعرفها، وهذه يعني دور من
+
+317
+00:28:11,170 --> 00:28:18,470
+أدوار الـCounselor إنه يؤديها. الـ
+
+318
+00:28:18,470 --> 00:28:24,810
+«دكتور»؟ نعم، في سؤال الماضي، بتسأل إنه مش كل
+
+319
+00:28:24,810 --> 00:28:29,190
+الـGenetic Disease بيكونوا Congenital؟ لأ، ما هو،
+
+320
+00:28:29,190 --> 00:28:33,630
+شوفي، أنا اتكلمت عن الموضوع هذا، يعني زي
+
+321
+00:28:33,630 --> 00:28:38,820
+Huntington’s Chorea أو Huntington’s Disease، هذا مرض
+
+322
+00:28:38,820 --> 00:28:46,060
+في الأعصاب، الإنسان بولد طبيعي، بعيش طبيعي، بخلف،
+
+323
+00:28:46,060 --> 00:28:51,740
+بيكون عائلة، على سن الأربعين، خمسين، ستين، بظهر عنده
+
+324
+00:28:51,740 --> 00:28:59,180
+المرض، وهو Autosomal Dominant. فكلمة Congenital تعني
+
+325
+00:28:59,180 --> 00:29:04,700
+«ظهرت عند الولادة». يعني لما نولد الإنسان، هاي
+
+326
+00:29:04,700 --> 00:29:09,710
+الشغلة مبينة عنده. فكلمة «congenital» يعني حكينا
+
+327
+00:29:09,710 --> 00:29:15,430
+«congenital toxoplasmosis»، «congenital rubella».
+
+328
+00:29:15,430 --> 00:29:20,010
+هدول يعني هن «congenital»، بس هدول «infectious
+
+329
+00:29:20,010 --> 00:29:24,050
+disease»، مش «genetic». فكلمة «genetic» و
+
+330
+00:29:24,050 --> 00:29:28,390
+«congenital» لا تعني نفس الكلمة، ماشي. يعني في
+
+331
+00:29:28,390 --> 00:29:31,630
+أمراض «genetic» مش «congenital»، لأن نقدرش نعتبرها
+
+332
+00:29:31,630 --> 00:29:35,530
+«congenital»، بس أحيانًا يعني «hereditary» و
+
+333
+00:29:35,530 --> 00:29:41,740
+«congenital» بتُعطى كأنه مصطلحات قريبان من بعض،
+
+334
+00:29:41,740 --> 00:29:46,320
+وكأنها نفس المعنى، يعني بقصد الواحد شيء، وراء شيء، يعني،
+
+335
+00:29:46,320 --> 00:29:52,100
+ماشي؟ فالوراثة مش ضروري تظهر عند الولادة، واضح؟
+
+336
+00:29:52,100 --> 00:29:56,020
+فلما الواحد يستخدم مصطلح، بده، بالذات إذا فيه
+
+337
+00:29:56,020 --> 00:30:02,080
+فروقات بينهم، بده ينتبه لها، ماشي؟ يعني Congenital
+
+338
+00:30:02,080 --> 00:30:08,540
+Heart Disease، ماشي؟ بيكون خلل معين هو خلقي، وحتى لو
+
+339
+00:30:08,540 --> 00:30:12,540
+ما اكتشفوش بالأول، بس لو كنت أنا فحصت عليه عند
+
+340
+00:30:12,540 --> 00:30:16,180
+الولادة، يعني مثلًا في Congenital Heart Disease الـ
+
+341
+00:30:16,180 --> 00:30:23,080
+«common» بيسمّوه «Bicuspid aortic valve»، الصمام
+
+342
+00:30:23,080 --> 00:30:27,320
+الأبهر، الـ«aortic»، المفروض له ثلاث شُفَائف، له ثلاث
+
+343
+00:30:27,320 --> 00:30:34,300
+قطع بالنسبة للناس، بتكون من قطعتين فقط. هذا ممكن إذا
+
+344
+00:30:34,300 --> 00:30:39,940
+ما حدش فحص عليه بدقة، أو دور عليه، يبين بعدين على سن
+
+345
+00:30:39,940 --> 00:30:44,660
+العشرين، ثلاثين، أربعين، بيبين. أو اكتشفناها، بيبين
+
+346
+00:30:44,660 --> 00:30:49,580
+عند الإنسان، بيخلي عنده يظهر مشكلة، تتطور، وبتبين
+
+347
+00:30:49,580 --> 00:30:54,790
+بعدين، فهي تلغى هذه النوع من المشكلة. صحيح إننا
+
+348
+00:30:54,790 --> 00:31:00,670
+اكتشفناها متأخر، بس هي خلقية، يعني congenital، يعني
+
+349
+00:31:00,670 --> 00:31:09,330
+من ولادته بدأت فيه، ماشي؟ بس مش كل congenital
+
+350
+00:31:09,330 --> 00:31:15,150
+بالضرورة genetic، خلينا نكون واضحين، ماشي؟ فاحنا
+
+351
+00:31:15,150 --> 00:31:20,530
+أحيانًا كثيرة نستخدم المصطلحين بشكل متبادل، بس هم
+
+352
+00:31:20,530 --> 00:31:22,770
+لأ، مش نفس المعنى.
+
+353
+00:31:27,150 --> 00:31:34,130
+واضح؟ ‏- لا، تمام يا دكتور. ‏- أه، الـGenetic
+
+354
+00:31:34,130 --> 00:31:40,070
+Counseling and Risk Assessment، يعني الـ، إحنا
+
+355
+00:31:40,070 --> 00:31:44,970
+المطلوب هنا، أول شيء، أن نفهم العائلة، الـMedical
+
+356
+00:31:44,970 --> 00:31:52,790
+Facts، يعني ضروري الـ، إذا العائلة يمكن أنه صعب أن
+
+357
+00:31:52,790 --> 00:31:56,750
+يدرس الواحد طب، ويدرس قليل من الـGenetics وكذا،
+
+358
+00:31:56,750 --> 00:32:01,610
+فالدور
+
+359
+00:32:01,610 --> 00:32:07,810
+الأول المطلوب، أنه نتأكد إنهم فاهمين النواحي
+
+360
+00:32:07,810 --> 00:32:17,310
+العلمية الطبية السليمة الأساسية، عن التشخيص، وندرسهم
+
+361
+00:32:17,310 --> 00:32:23,810
+على كيف تنتقل؟ وليه تنتقل؟ وما هي الخطورة أو
+
+362
+00:32:23,810 --> 00:32:28,930
+احتمالية عودة المشكلة معهم، أو في أعضاء العائلة
+
+363
+00:32:28,930 --> 00:32:35,610
+الآخرين؟ نعطيهم خيارات
+
+364
+00:32:35,610 --> 00:32:39,590
+ما يعملونه للمستقبل، وكيف يتعاملوا مع الحالة، يعني
+
+365
+00:32:39,590 --> 00:32:44,970
+أنا كثير مع الدكتورة، الله يرضى عنها، الدكتورة
+
+366
+00:32:45,560 --> 00:32:50,640
+الوراثة في الأطفال، التناقض في الحيط، نقعد مثلًا مع
+
+367
+00:32:50,640 --> 00:32:58,940
+عيلة عندهم مثلًا Phenylketonuria، ونسير يعني يكون
+
+368
+00:32:58,940 --> 00:33:02,620
+مثلًا الأب والأم يتلوموا، أنت المرض منك، أنت المرض
+
+369
+00:33:02,620 --> 00:33:08,220
+منك، لأ، المرض أنتم الاثنين مشتركون فيه، مثلًا يعني
+
+370
+00:33:08,220 --> 00:33:12,560
+هذه ناحية بدّو الواحد ينتبه لها. فمثلًا هذه
+
+371
+00:33:12,560 --> 00:33:17,440
+العائلات، بعضهم كنا ننصحهم مثلًا، خلاص، ما تخلفوش.
+
+372
+00:33:17,440 --> 00:33:24,440
+طبعًا في دول ثانية ممكن يكون مثلًا الإجهاض خيار، بس
+
+373
+00:33:24,440 --> 00:33:28,060
+إحنا مثلًا عندنا، نقول لهم، لأ، ما تخلفوش كمان ولاد
+
+374
+00:33:28,060 --> 00:33:33,200
+عشان لأنه لسه فيه نسبة، ونعتبرها نسبة عالية، لأنه
+
+375
+00:33:33,200 --> 00:33:41,560
+معاناة شديدة، أنه يكون هناك مرض، يعني بالنسبة لما
+
+376
+00:33:41,560 --> 00:33:46,560
+نتعامل بهذه النقاط. معرفة الـValues، Beliefs،
+
+377
+00:33:46,560 --> 00:33:52,520
+Goals، Relationships، نتيجة الـPresence of
+
+378
+00:33:52,520 --> 00:33:57,700
+Hereditary Diseases. يعني بدّه الواحد يراعي في هذا
+
+379
+00:33:57,700 --> 00:34:09,080
+الموضوع، بدنا نسميه ثقافة، دين، أخلاقيات، مفاهيم
+
+380
+00:34:09,080 --> 00:34:16,190
+الإنسان اللي أمامه. يعني إحنا بأقول دائمًا للدكاترة
+
+381
+00:34:16,190 --> 00:34:21,890
+وللطباء، إحنا لما واحد يصير طبيب، بقسم يعني بحلف
+
+382
+00:34:21,890 --> 00:34:29,210
+بالله، أنه راح نعالج القريب والعدو، الصالح والخاطر،
+
+383
+00:34:29,210 --> 00:34:37,550
+القريب والبعيد. يعني أنا كإنسان طبيب، لمن يلجأ لي شخص
+
+384
+00:34:37,550 --> 00:34:43,290
+لأنه طبيب، في أخلاقيات أنا مسؤول عنها، ومنها إنه
+
+385
+00:34:43,290 --> 00:34:47,950
+أحترم هذا الإنسان، أحترم خصوصيته، أحترم سرية
+
+386
+00:34:47,950 --> 00:34:54,510
+معلوماته، أحترم مفاهيمه. فهذا الاحترام بيكون بنتج عنه
+
+387
+00:34:54,510 --> 00:35:01,290
+إن أنا لازم أحترم طبعًا يعني النواحي الفردية هذه
+
+388
+00:35:01,290 --> 00:35:06,510
+التابعة له، بغض النظر عن إن أنا قابلها ولا مش قابلها،
+
+389
+00:35:06,510 --> 00:35:11,120
+عاجباني مش عاجباني، بسوي على حالي ولا لأ، خلاص، لازم
+
+390
+00:35:11,120 --> 00:35:16,400
+أحترم مين ما يكون أمامي، ماشي، وفي نفس الوقت يعني
+
+391
+00:35:16,400 --> 00:35:23,500
+أنا بظن جانب مهمة، إحنا لازم يعني في الجوانب هذه،
+
+392
+
+445
+00:40:57,160 --> 00:41:01,560
+المرض أو الحالة هذه نادرة واحتمالية وجودها قليلة
+
+446
+00:41:01,560 --> 00:41:10,040
+جداً، فمن النادر أن تعطي الأم هذا المرض لابنها أو ابنتها
+
+447
+00:41:10,040 --> 00:41:15,600
+هنا ما يحدث هو أن الاحتمالية تصبح ربع، فهذه الـ
+
+448
+00:41:15,600 --> 00:41:22,480
+Probability، ماشي، الـ Probability of being a
+
+449
+00:41:22,480 --> 00:41:26,900
+carrier يعني لديك نسخة واحدة، فهنا حاطين
+
+450
+00:41:26,900 --> 00:41:32,160
+النسب لمجموعة أفراد العائلة؛ الأب والأم يجب أن يكونا
+
+451
+00:41:32,160 --> 00:41:39,560
+حاملين.  Other first-degree relatives، النصف لكل
+
+452
+00:41:39,560 --> 00:41:44,420
+واحد منهم، أما الـ Second-degree relative فبتصير النسبة ربع
+
+453
+00:41:44,420 --> 00:41:54,820
+زي هنا، ماشي؟ سبب هذه النقطة هو أن
+
+454
+00:41:54,820 --> 00:41:57,920
+الـ
+
+455
+00:41:57,920 --> 00:42:03,820
+يعني النقطة التي أشرحها بهذه الطريقة هي أننا بثقة
+
+456
+00:42:03,820 --> 00:42:10,820
+نضع هذه النسب لسببين؛ السبب الأول هو أن العلاقات
+
+457
+00:42:10,820 --> 00:42:15,200
+واضحة، والسبب الثاني هو أن المرض واضح ونحن نعرفه
+
+458
+00:42:15,200 --> 00:42:19,680
+ونعرف الـ Gene الخاص به، ونستطيع فحصه عندما نكون
+
+459
+00:42:19,680 --> 00:42:24,140
+متأكدين وواثقين، لنعطِ أرقامًا كهذه، ولنكون
+
+460
+00:42:24,140 --> 00:42:30,180
+متأكدين من الموضوع، عندما لا يكون لدينا حالة مثل التوحد
+
+461
+00:42:30,180 --> 00:42:36,960
+أو مرض متنحي، ماشي؟ كشخص،
+
+462
+00:42:36,960 --> 00:42:44,360
+نحن، ماشي، لدينا إنسان مصاب، لكن، يعني ليس مثل
+
+463
+00:42:44,360 --> 00:42:48,060
+الوراثة المندلية المتنحية الصبغية، Autosomal Recessive Mendelian Inheritance، One
+
+464
+00:42:48,060 --> 00:42:54,880
+Position،  وانتهى الأمر، لا، هنا سأستخدم الإحصاء
+
+465
+00:42:54,880 --> 00:43:00,240
+وسأستخدم الاحتمالات، بحيث أتمكن من الوصول من خلال
+
+466
+00:43:00,240 --> 00:43:04,340
+معلومات عن المجتمع ككل؛ نسبة حدوث المرض، نسبة
+
+467
+00:43:04,340 --> 00:43:08,920
+انتشاره، نتيجة كذا، نتيجة كذا، ونضع بعض الأرقام
+
+468
+00:43:08,920 --> 00:43:16,280
+على احتمالاتها. عندما تأتي عائلة مثلاً، شخصان شكلهما
+
+469
+00:43:16,280 --> 00:43:22,000
+مظهرياً طبيعيان، ولديهم طفل مصاب. حسناً،
+
+470
+00:43:22,000 --> 00:43:26,440
+ما احتمالية أن يكون الطفل الثاني مصاباً بنفس
+
+471
+00:43:26,440 --> 00:43:31,240
+الطريقة؟ هل نأخذ بعض الأمثلة أم لا؟  فهنا
+
+472
+00:43:31,240 --> 00:43:37,460
+ما يميز هذا الكتاب والمرجع، هو أن الشكل يكتب لك، إذا أنتبهت،
+
+473
+00:43:37,460 --> 00:43:41,820
+فستجد شرائح كاملة مليئة بالمعلومات المفيدة
+
+474
+00:43:41,820 --> 00:43:47,020
+بشكل كبير.  يعني هنا كدراسة يقول لك
+
+475
+00:43:47,020 --> 00:43:55,420
+إذا كان متلازمة داون، Down Syndrome، ماشي، وبطبيعة الحال لها علاقة بـ…
+
+476
+00:43:55,420 --> 00:44:04,020
+يعني هي الـ Trisomy 21،  ويمكن أن يكون السبب Non-disjunction
+
+477
+00:44:04,020 --> 00:44:08,760
+و Trisomy 21، وعموماً لها علاقة بـ Maternal Age
+
+478
+00:44:08,760 --> 00:44:14,160
+و Trisomy 21،  بشكل عام، لها علاقة بـ Maternal Age
+
+479
+00:44:15,340 --> 00:44:20,040
+النسبة، احتمالية أن يكون الطفل الثاني مصاباً بنفس
+
+480
+00:44:20,040 --> 00:44:26,520
+الطريقة، 1%  بشكل عام. لكن إذا كان هناك تحويل روبرتسوني
+
+481
+00:44:26,520 --> 00:44:31,180
+Robertsonian Translocation، النسبة أعلى بكثير،  ربما 30 أو 20
+
+482
+00:44:31,180 --> 00:44:35,620
+مرة أعلى من أن يكون الطفل الثاني مصاباً أيضاً. لقد تحدثنا
+
+483
+00:44:35,620 --> 00:44:43,090
+كثيراً عن هذا المثال. يعني عندما نحصل على درجة،  مثل هذا
+
+484
+00:44:43,090 --> 00:44:48,450
+وهو الشخص المصاب، وأخ المصاب الذي اكتشفنا منه
+
+485
+00:44:48,450 --> 00:44:52,530
+المرض، وتأتي العائلة تسأل عن الوضع بالنسبة للقادم،
+
+486
+00:44:52,530 --> 00:44:56,650
+يجب أن يجمع الشخص معلومات قدر الإمكان، ويكون
+
+487
+00:44:56,650 --> 00:45:01,610
+فاهماً ماهيّة الـ inheritance، ولديه معلومات عنها الآن.
+
+488
+00:45:01,610 --> 00:45:14,600
+المثال الذي ذكرناه، هو هذه النقطة، المثال
+
+489
+00:45:14,600 --> 00:45:18,280
+الذي سبق، التوحد والمرض المتنحي. إذا أخذنا
+
+490
+00:45:18,280 --> 00:45:23,280
+التوحد والمرض المتنحي كمرض، ماشي؟ عندما يكون
+
+491
+00:45:23,280 --> 00:45:32,160
+لدينا شخص مصاب، نقول إن الأب والأم يجب أن يكونا
+
+492
+00:45:32,160 --> 00:45:37,820
+حاملين، حاملين بشكل مؤكد Obligate Carriers، يعني هما بالتأكيد حاملان
+
+493
+00:45:37,820 --> 00:45:46,760
+لإنجاب طفل مصاب. الفكرة في الـ A هي أن نتيجة أن
+
+494
+00:45:46,760 --> 00:45:52,080
+هنا نصاً نصاً "جين واحد"، "نسخة واحدة متأثرة" one gene، one copy affected
+
+495
+00:45:52,080 --> 00:45:57,740
+وبالتالي، لكي يظهر المرض المتنحي الصبغي autosomal recessive، يجب أن يكون متماثل الزيجوت homozygous، يجب أن يكون "متأثراً تماماً" too
+
+496
+00:45:57,740 --> 00:46:01,060
+affected. تصبح الاحتمالية ربع.  لكن الفكرة أن الربع هذه
+
+497
+00:46:01,060 --> 00:46:06,340
+مؤكدة، كيف مؤكدة؟  المقصود بها أن احتمالية كونها
+
+498
+00:46:06,340 --> 00:46:12,200
+ربع مؤكدة. جاء طفل مصاب، ثم، ماذا اسمه؟ مثلاً، هذه
+
+499
+00:46:12,200 --> 00:46:23,420
+عائلة ثانية في الـ B. بعد ذلك، أنجبوا ستة ذكور وإناث
+
+500
+00:46:23,420 --> 00:46:28,320
+وقد وضعوا معلوماتهم بهذه الطريقة. أنجبوا ستة،  وكلّهم أصحاء
+
+501
+00:46:28,320 --> 00:46:32,280
+الآن أصبحوا سبعة عند هذه العائلة، "ما احتمالية أن يكون الطفل
+
+502
+00:46:34,700 --> 00:46:39,880
+الثامن مصاباً؟"  لا يأتي أحد ويقول "بما أن ستة كانوا أصحاء،
+
+503
+00:46:39,880 --> 00:46:44,000
+فستكون احتمالية الإصابة أقل"، لا، تبقى ربع، ماشي،  وهي
+
+504
+00:46:44,000 --> 00:46:49,680
+استقلال النتائج، Independence of outcome،  باللغة الإحصائية
+
+505
+00:46:49,680 --> 00:46:55,380
+يقال إن الحدث العشوائي لا يحتفظ بذكرياته،
+
+506
+00:47:04,470 --> 00:47:10,330
+ماشي؟  الفكرة في الموضوع أنني ألقي قطعة
+
+507
+00:47:10,330 --> 00:47:17,230
+نقود، إما يظهر وجه، إما كتابة، ماشي؟ فالاحتمالية إذا كانت الأمور جيدة، نصف
+
+508
+00:47:17,230 --> 00:47:24,350
+فإذا ألقيتها عشر مرات، وكل مرة يظهر وجه، وجه، وجه،
+
+509
+00:47:24,350 --> 00:47:29,850
+وجه، وجه، وجه،  فهل المرة الحادية عشر ستظهر وجه أيضاً؟
+
+510
+00:47:30,690 --> 00:47:35,390
+ما الاحتمالية؟ نقول، بما أن كل حدث غير مرتبط
+
+511
+00:47:35,390 --> 00:47:41,650
+بالآخر، فستكون النتيجة نصف أيضاً بالنسبة لقطعة
+
+512
+00:47:41,650 --> 00:47:47,350
+النقود، أن يكون وجه أو كتابة، مهما كررت التجربة فهي
+
+513
+00:47:47,350 --> 00:47:55,660
+تبقى نصف. في الحالة A و B، عندما تكون الأمور معروفة ومفهومة، ماشي؟
+
+514
+00:47:55,660 --> 00:48:02,900
+لو أخذنا خياراً آخر أو احتمالية أخرى أو عائلة أخرى،
+
+515
+00:48:02,900 --> 00:48:10,520
+وهو أن امرأة تزوجت رجلاً أنجب منها طفلاً مصاباً، أنا
+
+516
+00:48:10,520 --> 00:48:15,140
+عرفت أنها حاملة، وهذه نسبة كونها حاملة للـ
+
+517
+00:48:15,140 --> 00:48:21,500
+carrier، للطفر الجيني Genetic Mutation، 100%. تزوجت رجلاً آخر، أنا
+
+518
+00:48:21,500 --> 00:48:28,600
+لا أعرف عنه شيئاً بعد، أو طلقت زوجها الأول وتزوجت رجلاً
+
+519
+00:48:28,600 --> 00:48:35,720
+آخر. هذا الشخص الثاني،  أنا لا أعرف عنه معلومات، فجاءت
+
+520
+00:48:35,720 --> 00:48:40,800
+هذه العائلة الجديدة،  تسال: "ما احتمالية أن
+
+521
+00:48:40,800 --> 00:48:51,300
+نجيب طفلاً مصاباً؟" الأمر هنا يرتبط بمعرفتنا، يعني ما
+
+522
+00:48:51,300 --> 00:48:57,860
+احتمالية أن يكون هذا الرجل حاملاً؟ هنا الوضع يختلف عن الحالة A
+
+523
+00:48:57,860 --> 00:49:04,360
+و B، السبب هو أنني لا أعرف ما إذا كان هذا الرجل لديه
+
+524
+00:49:04,360 --> 00:49:08,980
+هذا الجين أم لا. هنا تتغير الأمور بطريقتين: الطريقة
+
+525
+00:49:08,980 --> 00:49:15,880
+الأولى: علي أن أعرف أو أملك معلومة تقريبية عن
+
+526
+00:49:15,880 --> 00:49:24,210
+نسبة انتشار المرض في عامة السكان General Population، ماشي،
+
+527
+00:49:24,210 --> 00:49:28,470
+فما هو موجود هنا هو مثال، ونأخذه كمثال
+
+528
+00:49:28,470 --> 00:49:35,890
+افتراضي، أن هذا الجين موجود في واحد من كل 22 شخصاً
+
+529
+00:49:35,890 --> 00:49:42,650
+فاحتمالية أن يكون هذا الرجل يحمل جين وراثة
+
+530
+00:49:42,650 --> 00:49:49,390
+هذا المرض هي 1 من 22، ماشي، فالفكرة هي أنه عندما
+
+531
+00:49:49,390 --> 00:49:57,770
+نأخذ الآن الاحتمالات، كما رأينا هنا، عندما يكون
+
+532
+00:49:57,770 --> 00:50:11,370
+لدينا حدثان،  إذا اعتبرنا نسبتهما مختلفة، يعني
+
+533
+00:50:11,370 --> 00:50:20,400
+هنا نسبة نسخ المرض هي نصف، ماشي؟ وهنا 1 من 22، أعتقد أننا نضربها معاً، ويحسبون كيف ستكون
+
+534
+00:50:20,400 --> 00:50:27,040
+النتيجة، وهي 1 من 88. يعني هنا،  أضرب النسب
+
+535
+00:50:27,040 --> 00:50:37,960
+الاحتمالية ببعضها، والنتيجة هي... عندما نكون
+
+536
+00:50:37,960 --> 00:50:46,260
+يعني الأرقام هنا موجودة بالتفصيل في الشرح
+
+537
+00:50:46,260 --> 00:50:55,440
+وحاطينها بالنسبة ل...  عندما نقول هنا الـ Carrier، نسبة
+
+538
+00:50:55,440 --> 00:51:04,020
+100%، لكن الـ Carrier لديه نسخة واحدة only one copy، ماشي،  عندما أقول
+
+539
+00:51:04,020 --> 00:51:08,720
+1 من 22 لديه الجين،  1 من 22 تربيع أو 1 من 22
+
+540
+00:51:08,720 --> 00:51:13,860
+يعني نسيت الرقم، بحيث أنه إذا ضربت احتمالية هذا
+
+541
+00:51:13,860 --> 00:51:19,420
+باحتمالية هذا،  ستحصل على 1 من 88،  يعني هذا الرقم
+
+542
+00:51:19,420 --> 00:51:27,980
+هو المطلوب من المستشار الوراثي genetic counselor أن يقدمه بعد دراسة
+
+543
+00:51:27,980 --> 00:51:33,840
+طبيعة الوراثة وطبيعة المرض
+
+544
+00:51:33,840 --> 00:51:40,940
+وطبيعة الحالة. في الحالة الأولى A و B، أعرف
+
+545
+00:51:40,940 --> 00:51:45,200
+كل شيء، وبالتالي أستطيع حسابه بدقة. هنا يصبح لدينا
+
+546
+00:51:45,200 --> 00:51:51,730
+المجهولات أكثر. أعتقد أنهم كتبوا هنا
+
+547
+00:51:51,730 --> 00:51:56,470
+ليكون الناتج 88، أن احتمالية أن يكون الشخص حاملاً
+
+548
+00:51:56,470 --> 00:52:00,930
+للجين هي 1 من 22، فنضرب في أربعة (لأن النسبة ربع)، أو هكذا نحصل على
+
+549
+00:52:00,930 --> 00:52:08,530
+1 من 88، والتي تتضمن احتمالية الحدث
+
+550
+00:52:08,530 --> 00:52:13,390
+الآخر، لأنها نسبة أخرى.  مثلاً،  أحضر قطعة
+
+551
+00:52:13,390 --> 00:52:19,530
+نقود، وجه أو كتابة، ولدى حبة نرد،  أي مكعب
+
+552
+00:52:19,530 --> 00:52:25,170
+به أرقام 0، 1، 2، 3، 4، 5، 6، فأقول:  أمسك
+
+553
+00:52:25,170 --> 00:52:33,490
+الاثنين، وألقيها معاً، فأقول مثلاً: "ما احتمالية أن
+
+554
+00:52:33,490 --> 00:52:38,430
+يظهر الرقم ستة، والعملة وجه؟"  ليس صورة، يعني كتابة
+
+555
+00:52:38,430 --> 00:52:44,490
+يعني،  مثلاً، فاقول: احتمالية الصورة هي نصف، واحتمالية أن
+
+556
+00:52:44,490 --> 00:52:49,550
+يظهر الرقم ستة هي 1 من 6، فنصف ضرب 1 من
+
+557
+00:52:49,550 --> 00:52:59,690
+6، يصبح 1 من 12،  نضربهم ببعض.  الفكرة بهذه
+
+558
+00:52:59,690 --> 00:53:07,550
+الطريقة، لكي أقدر الاحتمالية.  الملاحظ هنا
+
+559
+00:53:07,550 --> 00:53:12,910
+هو أنه إذا كان هناك مجهول،  ماشي،  هنا قلنا أنه
+
+560
+00:53:12,910 --> 00:53:16,970
+صحيح، هنا جميع الأطفال الستة كانوا أصحاء،
+
+561
+00:53:16,970 --> 00:53:22,270
+لا يوجد لديهم مشكلة.
+
+562
+00:53:22,270 --> 00:53:33,090
+عندما يكون في العائلة مجهول، لا أعرف
+
+563
+00:53:33,090 --> 00:53:36,590
+ما لديه بالضبط،  ماشي؟  وأخذت نسبة عامة السكان
+
+564
+00:53:36,590 --> 00:53:38,430
+General Population Percentage،  إذا المرأة هذه عندما تزوجت
+
+565
+00:53:41,990 --> 00:53:49,850
+الرجلاً الثاني، أنجبت منه ستة أطفال، وكانوا جميعهم أصحاء،
+
+566
+00:53:49,850 --> 00:53:55,010
+ماشي،  لأن حقيقة أن الستة أطفال كانوا
+
+567
+00:53:55,010 --> 00:54:01,010
+أصحاء، هذا يجعلني أغير النسبة، ما احتمالية أن يكون
+
+568
+00:54:01,010 --> 00:54:06,450
+هذا الرجل سليماً تماماً؟ لو كان مثلاً القول هو أنني 1 من 22،
+
+569
+00:54:06,450 --> 00:54:12,320
+أكون حاملاً للمرض، لأنها نسبة عامة السكان، لكن عندما يكون
+
+570
+00:54:12,320 --> 00:54:19,240
+ست مرات، يكون  هذا الرجل غير حامل للمرض، يعني أنني
+
+571
+00:54:19,240 --> 00:54:24,320
+بثقة أكبر، أقول إن هذا الرجل غير حامل للمرض، وبالتالي، عندما
+
+572
+00:54:24,320 --> 00:54:30,540
+أجري الحسابات، ستجدونها، اقرؤوها، أقول هنا
+
+573
+00:54:30,540 --> 00:54:37,600
+تقريباً 1 من 476،  يعني تقريباً 1 من 500، خمس
+
+574
+00:54:37,600 --> 00:54:44,240
+مرات أقل احتمالية أن يكون الطفل القادم مصاباً بالمرض،  بسبب
+
+575
+00:54:44,240 --> 00:54:49,880
+أن الأشقاء الستة كانوا أصحاء،  ولديه أخ غير
+
+576
+00:54:49,880 --> 00:54:53,660
+شقيق من أمه،  كان مصاباً بهذا المرض، هكذا يجب على الشخص
+
+577
+00:54:53,660 --> 00:54:59,860
+أن يقرأها،  وينتبه إليها، يجب أن يكون الشخص ماهراً
+
+578
+00:54:59,860 --> 00:55:06,370
+في الرياضيات،  ودارس الإحصاء، وجيداً.  أتمنى أن أكون
+
+579
+00:55:06,370 --> 00:55:13,110
+قد شرحت معنى هذه الشريحة slide،  بأرقامها ومعانيها
+
+580
+00:55:13,110 --> 00:55:18,190
+النقطة التي... هنا،  عقدوا الموضوع في مسألة
+
+581
+00:55:18,190 --> 00:55:23,270
+الاحتمال الشرطي Conditional Probability،  يعني أنني حتى
+
+582
+00:55:23,270 --> 00:55:29,250
+أقيس ما احتمالية أن يكون حدث معين بشكل معين، ماشي،
+
+583
+00:55:29,250 --> 00:55:33,890
+يصبح،  أحتاج رياضياً أن أكون قادراً على تحليل
+
+584
+00:55:33,890 --> 00:55:34,410
+الموضوع بشكل سليم الآن
+
+585
+00:55:37,940 --> 00:55:43,540
+المثال الذي ذكرناه من قبل هو
+
+586
+00:55:43,540 --> 00:55:51,400
+التوحد والمرض المتنحي، عندما كان لدينا شخص مصاب،
+
+587
+00:55:51,400 --> 00:55:57,900
+المصاب
+
+588
+00:55:57,900 --> 00:56:08,850
+في هذه الحالة، والمرض المتنحي، الذكور والإناث
+
+589
+00:56:08,850 --> 00:56:14,650
+متساوون.  وعندما ظهر لدينا شخص مصاب، فأنا
+
+590
+00:56:14,650 --> 00:56:22,030
+متأكد 100% أن الأب والأم حاملان، هذه حقيقة Fact، يعني
+
+591
+00:56:22,030 --> 00:56:27,890
+انتهى الأمر.  نأخذ هنا مثلاً موضوعاً آخر، وهو
+
+592
+00:56:27,890 --> 00:56:33,890
+الوراثة المتنحية المرتبطة بالكروموسوم X،  X-linked recessive،  وهي النزف الهيموفيليا
+
+593
+00:56:33,890 --> 00:56:39,540
+وهي نقص عامل 8 وعامل
+
+594
+00:56:39,540 --> 00:56:43,740
+9،  أو عامل 9، وهي وراثة متنحية مرتبطة بالكروموسوم X، X-linked recessive، فأنا
+
+595
+00:56:43,740 --> 00:56:48,740
+أفترض أن لدي هنا سؤالاً،
+
+596
+00:56:48,740 --> 00:57:25,070
+السؤال: هذه المرأة،  التي عليها سهم،  تسأل عن
+
+597
+00:57:25,070 --> 00:57:34,290
+احتمالية أن تكون حاملة لمرض النزف الهيموفيليا،  في
+
+598
+00:57:34,290 --> 00:57:42,140
+حالة أنني أعرف أن اثنين من أعمامها كانا
+
+599
+00:57:42,140 --> 00:57:47,440
+إيجابيين، يعني اثنين من أعمامها كانا مصابين
+
+600
+00:57:47,440 --> 00:57:53,080
+وبالتالي، هي تسأل:  ما احتمالية أن أكون حاملة لهذا المرض؟
+
+601
+00:57:53,080 --> 00:58:02,420
+وأنا أنقله لأولادي وبناتي،  هنا  يوجد احتمالات
+
+602
+00:58:02,420 --> 00:58:15,170
+كون أعمامها مصابين، ماشي، يعني على
+
+603
+00:58:15,170 --> 00:58:22,250
+الأقل،  يجب أن تكون جدتها مصابة.  كلمة
+
+604
+00:58:22,250 --> 00:58:27,250
+الاحتمال الشرطي conditional probability، يعني أنني إذا
+
+605
+00:58:27,250 --> 00:58:36,080
+كان لدي ظواهر، وكل واحدة تحمل احتمالية مختلفة، أن
+
+606
+00:58:36,080 --> 00:58:39,700
+أنا بالنسبة
+
+607
+00:58:39,700 --> 00:58:45,640
+لاحتمالية حدوث هذا الشيء،  بما
+
+608
+00:58:45,640 --> 00:58:52,300
+فيه عدم يقين Uncertainty،  بشكل معين،  أرى
+
+609
+00:58:52,300 --> 00:58:57,120
+احتمالية كل الاحتمالات
+
+667
+01:04:07,480 --> 01:04:17,260
+ولمّا تأخذ، يعني هي بالأصل 1 على 64، وبعدين 1 على
+
+668
+01:04:17,260 --> 01:04:23,900
+34 وهنا الاحتمال الثاني، يعني احتمالية أن الجد
+
+669
+01:04:23,900 --> 01:04:30,260
+مصاب، تزوجت واحدًا غير مصاب، وبعدين البنت تزوجت
+
+670
+01:04:30,260 --> 01:04:38,120
+واحدًا غير مصاب، وهي (البنت) جاءت البنت تسأل، طبعًا هي
+
+671
+01:04:38,120 --> 01:04:42,180
+كمان بدأت تتزوج بواحد غير مصاب، هكذا الأصل، احتمالية
+
+672
+01:04:42,180 --> 01:04:46,920
+أن ينتقل المرض 1 على 43، هذه احتمالية هذه الحالة،
+
+673
+01:04:46,920 --> 01:04:53,900
+هذه الخطوة B بتكون احتماليّتها كمان 1 على 34
+
+674
+01:04:54,900 --> 01:04:59,580
+واحتمالية أن الجد مصاب، ولكن لم تُعدِها لبنتها، والبنت
+
+675
+01:04:59,580 --> 01:05:06,420
+بعدين لم تُعدِها للحفيدة هو 16 على 17، يعني 32 على 34
+
+676
+01:05:06,420 --> 01:05:11,640
+الفكرة أنه بعد ما عرفنا معلومات أكثر، أقدر أصبح
+
+677
+01:05:11,640 --> 01:05:17,840
+أعمل رياضيات وإحصاء بشكل أفضل، والنتيجة
+
+678
+01:05:17,840 --> 01:05:25,650
+النهائية أنه لما أجمع هذه النتائج: واحد على أربعة
+
+679
+01:05:25,650 --> 01:05:28,510
+وثلاثين، وواحد على أربعة وثلاثين، وستة عشر على سبعة عشر،
+
+680
+01:05:28,510 --> 01:05:33,930
+يُعطيني 100%، الاحتمال الكلي، فهذه ما تُسمى
+
+681
+01:05:33,930 --> 01:05:38,310
+Bayesian calculation، وهذه أنواع من الرياضيات
+
+682
+01:05:38,310 --> 01:05:47,290
+نُصبح نُجريها، لنحسب ما احتمالية أن البنت تكون
+
+683
+01:05:47,290 --> 01:05:53,720
+مصابة، وما احتمالية أنها تنقلها لأهلها؟ هنا
+
+684
+01:05:53,720 --> 01:05:59,020
+دائمًا، يعني هذا
+
+685
+01:05:59,020 --> 01:06:04,100
+مثال على مرض مثل الـHemophilia، واحتمال، يعني على
+
+686
+01:06:04,100 --> 01:06:11,740
+الأمور الرياضية التي فيها، بالنسبة لوراثة جين
+
+687
+01:06:11,740 --> 01:06:17,180
+مفهوم، Single gene، Mendelian، أنا أعرف عنه وأعرف
+
+688
+01:06:17,180 --> 01:06:25,680
+كيف، إن شاء الله، إذا قلت، يعني بالنسبة للـ Slides هذه
+
+689
+01:06:25,680 --> 01:06:32,540
+إذا لم تفهموا مني 100%، اسألوا الـ Organizer والذين
+
+690
+01:06:32,540 --> 01:06:38,440
+معكم، يعني لو قرأتُم ما في الكتاب بمفهومه بشكل
+
+691
+01:06:38,440 --> 01:06:42,400
+جيد، يمكن أنا لستُ بارعًا جدًا في الشرح، بالذات في هذا
+
+692
+01:06:42,400 --> 01:06:48,210
+الموضوع، والشغل الثاني أنه تريد واحدًا يفهم في الإحصاء،
+
+693
+01:06:48,210 --> 01:06:54,090
+يفهم في الاحتمالات، يدخل معك واحدًا واحدًا ويكون يُشاهد
+
+694
+01:06:54,090 --> 01:07:02,250
+لماذا نُجريها بهذه الطريقة، وتكون أن الـ الـ الـ
+
+695
+01:07:02,250 --> 01:07:08,030
+النتائج تكون بهذا الشكل، الاحتمال أو التعقيد الذي
+
+696
+01:07:08,030 --> 01:07:18,440
+بعد ذلك، هو يعني حالات نتكلم عن مرض
+
+697
+01:07:18,440 --> 01:07:22,820
+أنا لستُ أعرف بعدُ، يعني الحالة الأولى Autism and
+
+698
+01:07:22,820 --> 01:07:27,920
+Recessive، وأنا أعرف عنه وأعرف الجين، وأنا متأكد أن
+
+699
+01:07:27,920 --> 01:07:31,400
+الأب والأم لابد أن يكونا Carriers حتى يحدث المرض،
+
+700
+01:07:31,400 --> 01:07:36,800
+وأنا أعرف الـ Inheritance تبعه، فهذه قصة جميلة لما
+
+701
+01:07:36,800 --> 01:07:42,900
+يكون الزوج الثاني غير معروف، يصير الموضوع أعقد، أما
+
+702
+01:07:42,900 --> 01:07:47,900
+لما يكون عندي أيضًا مجاهيل أكثر، بيصير بده إحصاء
+
+703
+01:07:47,900 --> 01:07:52,660
+أصعب، وبالنتيجة تكون يعني معقدة أكثر، أريد الواحد
+
+704
+01:07:52,660 --> 01:08:02,100
+يتبع معهم بالنسبة لأرقام، كيف تكون الـ … الـ … الـ …
+
+705
+01:08:02,100 --> 01:08:08,050
+الـ B-degree الثالث، أو النموذج الثالث أو الرابع، هو
+
+706
+01:08:08,050 --> 01:08:15,830
+إذا عائلة عندهم مرض نادر أو غير معروف، ننتبه، بس أقول
+
+707
+01:08:15,830 --> 01:08:22,070
+في الـ Slides هذا، أنه أنا جزء من تعاملي مع
+
+708
+01:08:22,070 --> 01:08:28,490
+الاحتمالية هنا، أكون أعتمد على رقمين، الرقم الأول
+
+709
+01:08:28,490 --> 01:08:36,900
+شو احتمالية أن المرض نتيجة جين موروث في
+
+710
+01:08:36,900 --> 01:08:40,840
+المجتمع، يعني مثل الذي حكينا عنه الـ Hemophilia، و
+
+711
+01:08:40,840 --> 01:08:43,960
+الـ Bq، لأن الـ Autism is recessive أو Existently
+
+712
+01:08:43,960 --> 01:08:47,700
+recessive، ولا كذا، ما أُعطيك نسبة، وواحد في المئة، و
+
+713
+01:08:47,700 --> 01:08:52,300
+واحد في العشرة، وواحد في الألف، و نريد أن نلاحظ هذا،
+
+714
+01:08:52,300 --> 01:08:59,020
+يُدخل، ولكن لدي احتمالية ثانية، هي New
+
+715
+01:08:59,020 --> 01:09:05,360
+Mutation، من نفسها تنشأ، وما احتمالية أن تنشأ هذه
+
+716
+01:09:05,360 --> 01:09:11,320
+الـ mutation الجديدة، يعني تكون غير نتيجة وراثة
+
+717
+01:09:11,320 --> 01:09:19,220
+لازمة من الأبوين، فهنا التعقيد سيكون أن
+
+718
+01:09:19,220 --> 01:09:27,440
+الاحتمالية الجين في المجتمع، وهنا يُسمى H، ماشي؟
+
+719
+01:09:30,260 --> 01:09:37,740
+واحتمالية أن New Mutation نسميه الـ Mu، فيصبح
+
+720
+01:09:37,740 --> 01:09:44,480
+عندي أرقام مختلفة، وهنا حاطين مثال
+
+721
+01:09:44,480 --> 01:09:50,020
+X-Linked Genetic Lethal Disorder، ماذا يعني؟ يعني هنا
+
+722
+01:09:50,020 --> 01:09:56,620
+حالة أن هذا الذكر المصاب، لأنه X-Linked
+
+723
+01:09:56,620 --> 01:10:04,120
+Recessive Lethal، يعني لن يعيش، أو الـ دوشين
+
+724
+01:10:04,120 --> 01:10:08,920
+مسكولر ديستروفي، الأطفال الذين يولدون بهذه الحالة
+
+725
+01:10:08,920 --> 01:10:14,440
+يُظهرون ضعفًا، عضلاتهم ضامرة، ويتوفون عند سن العشر
+
+726
+01:10:14,440 --> 01:10:19,040
+سنين، نسبة عالية جدًا، كلهم يموتون قبل سن العشر سنوات، قبل
+
+727
+01:10:19,040 --> 01:10:22,800
+أن توجد احتمالية أن يُخلفوا هم
+
+728
+01:10:22,800 --> 01:10:27,560
+بحالهم، فالـ دوشين مسكولر ديستروفي، في حالة مثل هذه،
+
+729
+01:10:28,300 --> 01:10:38,080
+الـ … الـ … الـ … وجود طفل لديه هذه الحالة،
+
+730
+01:10:38,080 --> 01:10:43,800
+فيأتي الأهل ليسألوا: "طيب، وبعد ذلك، المرة الثانية،
+
+731
+01:10:43,800 --> 01:10:48,820
+ما الاحتمالات؟ وماذا وكذا؟" أنا هنا أبدأ أدخل أن
+
+732
+01:10:48,820 --> 01:10:56,260
+هناك احتمال أن الـ … الـ … الأم، ماشي، هي Carrier،
+
+733
+01:11:03,240 --> 01:11:07,280
+Carrier، وأنها حدثت mutation في الطفل نفسه، ولكن بما
+
+734
+01:11:03,240 --> 01:11:03,240
+هنا مثل في الاحتمال رقم 2، ولكن الاحتمال أن لا هي ليست
+
+735
+01:11:07,280 --> 01:11:11,200
+أنّه X-linked، و One copy، وحدثت mutation، والـ copy
+
+736
+01:11:11,200 --> 01:11:17,640
+أصبحت مضروبة، فيصبح أن هنا يعني الـ mutation عنده، وهي
+
+737
+01:11:17,640 --> 01:11:24,280
+تحدث بالنسبة لـ μ، بالتالي، يعني نريد أن نتكلم عن
+
+738
+01:11:24,280 --> 01:11:28,430
+احتمالية بهذه الطريقة، يعني هنا أن الأم والأب، لا أحد
+
+739
+01:11:28,430 --> 01:11:31,410
+منهم Carrier، لا أحد لديه شيء، فهي mutation في الطفل
+
+740
+01:11:31,410 --> 01:11:41,950
+نفسه، هنا الأم هي عبارة عن ما يُسمى Carrier، وبالتالي
+
+741
+01:11:41,950 --> 01:11:47,830
+انتقال المرض لابنها، في احتمالية ثالثة أن مثلًا لو
+
+742
+01:11:47,830 --> 01:11:55,490
+جدّته، يعني عنده من أُخواله أحد مصاب، ماشي؟ يعني هذه
+
+743
+01:11:55,490 --> 01:11:59,350
+المرأة هنا حامل، ولكننا لم نعرف إذا كان هناك إخوة
+
+744
+01:11:59,350 --> 01:12:05,730
+آخرين، يعني إخوة هذا الولد كان أحد توفى بهذا
+
+745
+01:12:05,730 --> 01:12:11,550
+المرض، ماشي؟ ويعني كان هناك شخص آخر، فإذا كان من
+
+746
+01:12:11,550 --> 01:12:14,970
+أخوة المصابين، تصبح أن نعم والله الجدّ كانت
+
+747
+01:12:14,970 --> 01:12:19,010
+مصابة، فنلاحظ أن
+
+748
+01:12:21,830 --> 01:12:23,970
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+749
+01:12:23,970 --> 01:12:24,270
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+750
+01:12:24,270 --> 01:12:24,310
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+751
+01:12:24,310 --> 01:12:24,630
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+752
+01:12:24,630 --> 01:12:29,030
+الـ الـ
+
+753
+01:12:29,030 --> 01:12:33,430
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+754
+01:12:33,430 --> 01:12:35,150
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+755
+01:12:35,150 --> 01:12:35,550
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+756
+01:12:35,550 --> 01:12:37,250
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+757
+01:12:37,250 --> 01:12:38,070
+الـ الـ
+
+758
+01:12:43,650 --> 01:12:48,050
+الجد هي التي كانت مصابة، نقلتها لبنتها، ومن بنتها
+
+759
+01:12:48,050 --> 01:12:54,150
+للحفيد، أصابته بالمرض، فاحتمالية هذه الحالات الثلاث
+
+760
+01:12:54,150 --> 01:12:58,310
+ستأتي لتتجمع إلى 100%، لأن هذه كل التي تكون في الـ
+
+761
+01:12:58,310 --> 01:13:02,790
+Combinations، ولما نأتي لنحسب ما احتمالية الطفل
+
+762
+01:13:02,790 --> 01:13:06,550
+الذي يليه، أو ما احتمالية أن كذا، تُحسب لمن
+
+763
+01:13:06,550 --> 01:13:10,690
+طلب الاستشارة، ممكن نعطيه الأرقام حسب الدراسة
+
+764
+01:13:12,890 --> 01:13:19,590
+فيعني نتيجة هذا العمل نجد أن مثلًا لو أخذنا
+
+765
+01:13:19,590 --> 01:13:27,050
+موضوع مثل الـ Birth Defect، التي هي يعني العيوب
+
+766
+01:13:27,050 --> 01:13:31,410
+الخلقية، بالنسبة لأشياء مثل Cleft Lip، أو Cleft
+
+767
+01:13:31,410 --> 01:13:33,750
+Palate، أو Congenital Heart Disease، أو كذا،
+
+768
+01:13:33,750 --> 01:13:42,970
+الـ Consanguinity تزيد نسبة هذه الاحتمالية، فلو جئنا
+
+769
+01:13:42,970 --> 01:13:50,030
+أخذنا ألف وليد جديد، المواليد الجدد، أن يكون فيه
+
+770
+01:13:50,030 --> 01:13:57,310
+birth defect من هذه الأنواع، ماشي، تظهر تقريبًا 1.5
+
+771
+01:13:57,310 --> 01:14:07,730
+%، 15 حالة، عندما يكون الزواج متباعد، يعني 1% إذا كان
+
+772
+01:14:07,730 --> 01:14:12,520
+في الـ First Cousin Marriage، أكثر من الضعف، تصبح
+
+773
+01:14:12,520 --> 01:14:21,260
+احتمالية أن يكون هناك birth defect، فهي تصل إلى 36 في
+
+774
+01:14:21,260 --> 01:14:31,160
+الألف، وإذا الطفل، يعني couple، زوج، جاءهم أول طفل كان
+
+775
+01:14:31,160 --> 01:14:39,080
+مصاب، ماشي، لو كان هناك ألف من هذه العائلات، ألف عائلة كان
+
+776
+01:14:39,080 --> 01:14:46,160
+عندهم طفل مصاب أولًا، أن يكون مصاب ثاني يكون ثلاثون
+
+777
+01:14:46,160 --> 01:14:52,040
+في الألف، يعني ثلاثة بالمئة، يعني ضعف هؤلاء، ولما
+
+778
+01:14:52,040 --> 01:14:57,300
+يكون هناك Consanguinity، يعني هنا تقريبًا أربع مرات
+
+779
+01:14:57,300 --> 01:15:03,540
+ونصف، أقل قليلًا من خمس مرات، ماشي، يصير الزيادة، فما
+
+780
+01:15:03,540 --> 01:15:07,200
+يعني النقطة التي نريد أن نفهمها هنا، جزء من الموضوع
+
+781
+01:15:07,200 --> 01:15:14,440
+أن زواج الأقارب يزيد احتمالية أن يكون هناك أمراض
+
+782
+01:15:14,440 --> 01:15:23,190
+وراثية تظهر، ويكون يعني رياضيًا، وهنا كتجربة من
+
+783
+01:15:23,190 --> 01:15:31,710
+إحصائية ودراسة للمواليد، حسب درجة قرابة العائلة بين
+
+784
+01:15:31,710 --> 01:15:36,530
+الزوجين، وحسب التاريخ السابق، أن كان هناك إصابة من
+
+785
+01:15:36,530 --> 01:15:46,050
+هذا النوع أو لا، كلها تزيد، النقطة هذه، يعني هذا الفصل،
+
+786
+01:15:46,050 --> 01:15:53,500
+هذا الكلام أظن من ناحية مهمة جدًا، ولا بد أن يكون في
+
+787
+01:15:53,500 --> 01:15:59,220
+كل وزارة صحة، في كل مجموعة صحية تهتم بـ
+
+788
+01:15:59,220 --> 01:16:07,140
+Population معينة في مجتمع، أن يكون هناك أشخاص يعملون
+
+789
+01:16:07,140 --> 01:16:11,340
+Genetic Counseling، وجزء من الـ Genetic Counseling
+
+790
+01:16:11,340 --> 01:16:19,480
+أن أيضًا نعمل، نعطي تقييمًا إحصائيًا رقميًا، بما احتمالية
+
+791
+01:16:19,480 --> 01:16:23,860
+أن يكون الإنسان حامل للـ Gene، ما احتمالية الإصابة
+
+792
+01:16:23,860 --> 01:16:30,440
+في أي شخص، حسب العلوم والرياضيات والأرقام بالشكل
+
+793
+01:16:30,440 --> 01:16:37,500
+الذي حكينا، وتختلف إذا أنا أعرف أنه بثقة، أو شيء
+
+794
+01:16:37,500 --> 01:16:42,680
+مجهول فيه، أو لا يوجد، أضع كل الاحتمالات وأدرسها،
+
+795
+01:16:42,680 --> 01:16:55,080
+ويعني على ضوئها أصبح أتكلم بشكل علمي، في أسئلة؟ في
+
+796
+01:16:55,080 --> 01:17:01,060
+أحد لديه استفسار؟ هذه النقطة، هذه النقاط أنا أقترح
+
+797
+01:17:01,490 --> 01:17:07,410
+الكتاب لديكم أيضًا، يعني أنا حاولت أفهم الـ general
+
+798
+01:17:07,410 --> 01:17:14,290
+idea، وطريقة الـ approach، يعني التي هي أن أريد
+
+799
+01:17:14,290 --> 01:17:21,010
+أسير حتى لما يُسألوني ما احتمالية كذا لشخص معين، أريد
+
+800
+01:17:21,010 --> 01:17:26,200
+آخذ كل شجرة العائلة، أرى ما احتمالية الـ، هل هي
+
+801
+01:17:26,200 --> 01:17:32,260
+مثل الـ General Population لهذا الموضوع؟ أم هناك
+
+802
+01:17:32,260 --> 01:17:36,400
+محددات أكثر؟ وأدخل كل الاحتمالات معًا، وأُخرج
+
+803
+01:17:36,400 --> 01:17:45,160
+الرقم؟ فضلًا، إذا أحد لديه سؤال، يعني
+
+804
+01:17:45,160 --> 01:17:48,880
+يا دكتور، هذه النقاط مطالبون بها، أن في الامتحان
+
+805
+01:17:48,880 --> 01:17:52,000
+نتوسع أم فقط نلتزم بما شرحته في هذه
+
+806
+01:17:52,000 --> 01:17:58,890
+النقاط؟ ليس داخل في الموضوع، وما اسمه؟ يعني هكذا، لا
+
+807
+01:17:58,890 --> 01:18:04,770
+تريد أن تكوني فهمتني، يعني، لما قلت والله لديّ
+
+808
+01:18:04,770 --> 01:18:11,150
+عملة معدنية، وجه أو كتابة، وحجر نرد عليه ستة
+
+809
+01:18:11,150 --> 01:18:16,330
+أوجه، من واحد لستة، ما احتمالية أن يظهر لي رقم ستة، زائد
+
+810
+01:18:16,330 --> 01:18:23,000
+يظهر لي العملة وجهًا؟ ماشي؟ فهمت عليّ؟ فتريد
+
+811
+01:18:23,000 --> 01:18:26,640
+أن تكوني لديك أساس، هكذا المفروض يعني يبدأ الواحد
+
+812
+01:18:26,640 --> 01:18:30,740
+شيئًا من الرياضيات يكون فاهمًا إياها، فالمطلوبون، ليس
+
+813
+01:18:30,740 --> 01:18:37,120
+المطلوبون، أنا بصراحة، يعني ما أحاول أن أسويه
+
+814
+01:18:37,120 --> 01:18:44,320
+الذي هو الموضوع أن، كما الـ US M&E كتبت لكم أن
+
+815
+01:18:44,320 --> 01:18:49,940
+هذا يأتي، أريد أن أقول، أريد أن آتي بمثله، ماشي؟ فهذه ناحية
+
+816
+01:18:49,940 --> 01:18:57,880
+ثانية، الناحية الثالثة، يعني التي رأيتها، تتكلم عن
+
+817
+01:18:57,880 --> 01:19:00,500
+الـ Posterior Probability، والـ Conditional
+
+818
+01:19:00,500 --> 01:19:05,260
+Probability، يعني هذه مفاهيم في الإحصاء، أنا أريد
+
+819
+01:19:05,260 --> 01:19:10,540
+الواحد أن يكون فهمه عن المفهوم، ماشي؟ الرقم والحساب
+
+820
+01:19:10,540 --> 01:19:16,560
+والضرب، يعني مرات حتى الواحد يخطئ فيه، وينقل الأرقام
+
+821
+01:19:16,560 --> 01:19:22,220
+أو لا، ولكن الفكرة أن أريد الواحد أن يضعه كمثال، ماشي؟
+
+822
+01:19:22,220 --> 01:19:26,240
+ويضعه كشيء مفهوم، هم الذين وضعوا مثالين، كلها
+
+823
+01:19:26,240 --> 01:19:29,760
+تقريبًا Autosomal Recessive، أو إذا كان هناك lethal، أو
+
+824
+01:19:29,760 --> 01:19:33,100
+كذا، فعندنا ما يُسمى Conditional Probability، أو
+
+825
+01:19:33,100 --> 01:19:40,480
+كذا، الآن أتمنى أن إذا قرأتُم، تفهمون، ماشي؟ وإذا
+
+826
+01:19:40,480 --> 01:19:44,810
+الواحد فهم، لا يخطئ، إذا من مئة سؤال وضعتُ سؤالًا على
+
+827
+01:19:44,810 --> 01:19:49,330
+ما مثل هذا، يمكن أن يبدو قليلًا صعبًا، يمكن كذا، ما هو
+
+828
+01:19:49,330 --> 01:19:52,950
+كي نفرق البارع عن الأقل براعة، يعني ما يريد
+
+829
+01:19:52,950 --> 01:19:58,510
+أسوأ؟ ماشي؟ أما مطلوب، غير مطلوب، لا، لا أقدر
+
+830
+01:19:58,510 --> 01:20:02,090
+أجيب، لا أعرف، كل شيء عليك، آميسيا يا دكتور، أنا
+
+831
+01:20:02,090 --> 01:20:05,310
+كنتُ أُشير إلى، هل نتوسع فيه أكثر أم نلتزم بما
+
+832
+01:20:05,310 --> 01:20:11,830
+شرحته أو كذا؟ لا، كل مثال من الأمثلة التي جئت بها
+
+833
+01:20:11,830 --> 01:20:17,2
+
+889
+01:25:23,200 --> 01:25:29,100
+دكتور، الله يحييكم. في أسئلة في نفس المثال أو في نفس
+
+890
+01:25:29,100 --> 01:25:31,460
+الأشياء، مش مطلوب، ولا مش مطلوب؟ يعني ما أنتم
+
+891
+01:25:31,460 --> 01:25:35,820
+سألوني هذا السؤال؟ آه، لأ لأ، كله واضح إن شاء الله.
+
+892
+01:25:35,820 --> 01:25:42,000
+طيب، الفصل الثاني اليوم
+
+893
+01:25:44,060 --> 01:25:49,700
+على موضوع برضه الـ Counselor اللي دخل فيه، ويمكن من
+
+894
+01:25:49,700 --> 01:25:53,280
+أهم جوانب العملية في قضية الـ Genetic Diseases.
+
+895
+01:25:53,280 --> 01:25:59,820
+أحيانًا في مواضيع اللي بيسموها أنه يكون «Prenatal
+
+896
+01:25:59,820 --> 01:26:03,460
+Diagnosis and Screening»، يعني هي شو نعمل في
+
+897
+01:26:03,460 --> 01:26:07,380
+الأمراض الوراثية في المجتمع، وكيف نقاومها، وكيف
+
+898
+01:26:07,380 --> 01:26:08,360
+نتعامل معاها.
+
+899
+01:26:11,320 --> 01:26:15,860
+الأمثلة على الأشياء هذه، أنا بقول خلّينا نحطها
+
+900
+01:26:15,860 --> 01:26:22,120
+بثلاث جوانب في النقطة.
+
+901
+01:26:22,120 --> 01:26:26,660
+الأولى، خلّينا قبل ما نبدأ، من الأشياء المهمة
+
+902
+01:26:26,660 --> 01:26:31,860
+للتعامل مع الأمراض الوراثية، أول شيء الـ Premarital
+
+903
+01:26:31,860 --> 01:26:37,000
+diagnosis و Screening، يعني اللي هو فحص الطبي قبل
+
+904
+01:26:37,000 --> 01:26:44,490
+الزواج، ماشي؟ أحيانًا كثيرًا، يعني إحنا بالقانون في
+
+905
+01:26:44,490 --> 01:26:48,810
+الأردن، المأذون هو، أتوقع كمان إن شاء الله في غزة،
+
+906
+01:26:48,810 --> 01:26:54,710
+بيكونوا بيطبقوا نفس الأشياء، أو أشياء زيها. قضية إنه
+
+907
+01:26:54,710 --> 01:26:58,350
+مثلًا، اللي بدهم يتزوجوا لازم يروحوا على مختبر طب،
+
+908
+01:26:58,350 --> 01:27:03,430
+ويعملوا CBC، ويشوفوا الواحد عشان مرض أنيميا البحر
+
+909
+01:27:03,430 --> 01:27:08,900
+الأبيض المتوسط، اللي هو الـ Thalassemia، ماشي؟ حتى
+
+910
+01:27:08,900 --> 01:27:12,400
+نشخصهم، بنروح بنقول لهم روحوا تعملوا فحص الزواج قبل
+
+911
+01:27:12,400 --> 01:27:17,460
+الزواج، وبندور على Microcytosis، اللي هي مثال يعني،
+
+912
+01:27:17,460 --> 01:27:22,940
+دليل على، في الغالب، على الـ Microcytic، اللي هو يعني
+
+913
+01:27:22,940 --> 01:27:28,640
+carrier state للـ Thalassemia. وإذا اثنين هم، إذا
+
+914
+01:27:28,640 --> 01:27:32,980
+واحد بس اللي عنده الحالة، نقول لهم الله يسهل عليكم،
+
+915
+01:27:32,980 --> 01:27:37,540
+اتجوزوا وكملوا، الله يرزقهم و يفتح عليكم. أما إن إذا
+
+916
+01:27:37,540 --> 01:27:43,000
+اثنين حاملين، واثنين عندهم الـ possibility، فهنا
+
+917
+01:27:43,000 --> 01:27:46,780
+بتصير الاحتمالية إنه ندخل في مشاكل، ويكون الطفل
+
+918
+01:27:46,780 --> 01:27:52,180
+عنده ثلاسيميا، وهذا بيغلب عليه، وعلى أهله، وعلى مجتمعه،
+
+919
+01:27:52,180 --> 01:27:56,200
+وعلى كذا. يعني الـ Thalassemia Child، It's a long
+
+920
+01:27:56,200 --> 01:28:01,200
+life disease، وما بيكونش حياتهم طبيعية وصحية،
+
+921
+01:28:01,200 --> 01:28:06,120
+وبيتعبوا، ومرضاني، وبياخدوا نقل دم، وبيدخلوا بـ
+
+922
+01:28:06,120 --> 01:28:12,820
+Heart Failure، يعني بتعذّب هو وأهله. فممكن واحد يقول
+
+923
+01:28:12,820 --> 01:28:21,710
+إن أنا أسوي شيء يعني ما قبل الزواج، حتى هذا وارد.
+
+924
+01:28:21,710 --> 01:28:25,890
+وممكن إنه مثلًا، إذا في عائلة، أو في مجتمع في عندهم
+
+925
+01:28:25,890 --> 01:28:32,750
+احتمالية مرض معين، ممكن أنا أدور على إنه يكون تطابق
+
+926
+01:28:32,750 --> 01:28:38,090
+الشخصين بشكل يمنع هذا المرض. الموضوع الثاني، حكينا
+
+927
+01:28:38,090 --> 01:28:45,430
+برضه عن جانب منه، اللي هو قضية اللي هو موضوع عند
+
+928
+01:28:45,430 --> 01:28:51,770
+الولادة، من أول ما يولد بسوي Screening فيه، يعني حتى
+
+929
+01:28:51,770 --> 01:28:56,450
+الآن، حتى في دول متقدمة، إحنا، أنا حكينا الأردن مثلًا،
+
+930
+01:28:56,450 --> 01:29:01,670
+بنعمل على ثلاث أشياء بـ Very Simple Test، وطخة واحدة،
+
+931
+01:29:01,670 --> 01:29:06,030
+وشغلتها بسيطة في المختبر، بس بيعملوها لكل الأطفال،
+
+932
+01:29:06,350 --> 01:29:12,250
+اللي هم الـ Creditism أو الـ Hypothyroidism، نفحص
+
+933
+01:29:12,250 --> 01:29:17,550
+الـ TSH بدم الجنين، وبالتالي بنقدر نعرف إذا عنده،
+
+934
+01:29:17,550 --> 01:29:22,650
+بنعطيها الـ Thyroxine. شغل Simple، Easy، من تنقذه من
+
+935
+01:29:22,650 --> 01:29:29,610
+مرض سيء جدًا، ماشي؟ الـ Thyroid Disease، الـ PKU،
+
+936
+01:29:29,610 --> 01:29:35,050
+برضه بنعمله، دخلناها، والفكرة فيه إنه إذا أكل لوغ
+
+937
+01:29:37,370 --> 01:29:42,090
+بالفีนيل ألانين بالذات، كـ Amino Acid، بيكون الطفل
+
+938
+01:29:42,090 --> 01:29:45,190
+طبيعي، ما عنده أي مشكلة بالنسبة لـ Mental
+
+939
+01:29:45,190 --> 01:29:49,430
+retardation ولا أي شيء ثاني. فهي بنعملها، وحكاية الـ
+
+940
+01:29:49,430 --> 01:29:54,170
+HIV برضه بيعملوه، من باب الـ Screening، في دول ثانية
+
+941
+01:29:54,170 --> 01:29:58,270
+مثلًا بيعملوا Screening على الـ بعد الولادة على كل
+
+942
+01:29:58,270 --> 01:30:03,930
+الـ Immune Deficiencies، فبرضه يعني عندهم إمكانيات،
+
+943
+01:30:03,930 --> 01:30:10,600
+وعندهم يعني طرق، أنه كمختبر نفحص لكل المواليد الجدد،
+
+944
+01:30:10,600 --> 01:30:14,860
+ونسوي الـ Screening ضمن بقية الـ Screening للأشياء،
+
+945
+01:30:14,860 --> 01:30:20,140
+التانية. النقطة اللي راح نتكلم عنها في الفصل هذا هي
+
+946
+01:30:20,140 --> 01:30:27,800
+جوانب، نفحص على الجنين، وهو لسه بطن أمه، والأمر يعني،
+
+947
+01:30:27,800 --> 01:30:34,760
+سواء كأخلاقي، راح نتكلم عن جوانب الأخلاقية في محاضرة
+
+948
+01:30:34,760 --> 01:30:43,160
+قادمة. موضوع كيف، شو نعمل بالنسبة إذا شخصنا شيء،
+
+949
+01:30:43,160 --> 01:30:48,320
+يعني في ثقافات، وحكينا إحنا مضطرين للاحترام،
+
+950
+01:30:48,320 --> 01:30:54,400
+للثقافات المختلفة، القوانين المختلفة، الأديان
+
+951
+01:30:54,400 --> 01:31:01,960
+المختلفة. الأديان، الأديان، يعني الإسلام، ويعني مثلًا،
+
+952
+01:31:01,960 --> 01:31:07,220
+بين إخواننا المسيحيين الكاثوليك مثلًا، الإجهاض حرام،
+
+953
+01:31:07,220 --> 01:31:12,580
+إحنا في الإسلام، ومثلًا الكاثوليكيين الإجهاض فقط
+
+954
+01:31:12,580 --> 01:31:18,760
+حلال لإنقاذ حياة الأم، يعني للمحافظة على الأصل أنت،
+
+955
+01:31:18,760 --> 01:31:25,120
+تضحي بالفرع، هيك يعني، بأرضه، على أساس أنه الجنين فرع
+
+956
+01:31:25,120 --> 01:31:30,740
+من أمه، وإنه يعني بندخل في موضوع، حتى بالنسبة كإجهاض،
+
+957
+01:31:30,740 --> 01:31:35,160
+في الإسلام، في قضية متى نفخ الروح، اللي هو إنسان
+
+958
+01:31:35,160 --> 01:31:40,240
+منفصل، أو مش منفصل، وندخل في الموضوع هذا، بس في أشياء
+
+959
+01:31:40,240 --> 01:31:46,560
+نقدر نسويها، وخصوصًا إذا ثقافة أو مجتمع يعني، في
+
+960
+01:31:46,560 --> 01:31:51,240
+الدول الغربية، في تفاوت، في أمريكا مثلًا على قضية
+
+961
+01:31:51,240 --> 01:31:57,820
+الإجهاض. النساء بتقول لك، ها الحمل، طالما هو لسه بطني،
+
+962
+01:31:57,820 --> 01:32:01,840
+هو جزء مني، وأنا مسؤولة عنه، وأنا اللي بتحمله، وأنا
+
+963
+01:32:01,840 --> 01:32:07,660
+اللي بسوي. وبالتالي، يعني حتى لو بالشهر التاسع، وبدها
+
+964
+01:32:07,660 --> 01:32:15,260
+تعمل إجهاض، يعني هذا كتلة دم ولحم، وما له قيمة، وأنا
+
+965
+01:32:15,260 --> 01:32:21,630
+خلصت من ورم، وخلاص. ماشي؟ فالإجهاض يعني، هو في كل
+
+966
+01:32:21,630 --> 01:32:28,150
+المستغرب بعد التأخير، يعني أصلًا إذا بدأت قررت إجهاض،
+
+967
+01:32:28,150 --> 01:32:33,250
+الأول، تعمله بفترة مبكرة، يعني قبل ما يتخلق أو يبين
+
+968
+01:32:33,250 --> 01:32:39,430
+إنه إنسان، أو قريب من الإنسان، بس بيظل إنه يعني، في
+
+969
+01:32:39,430 --> 01:32:46,100
+أطباء، وفي كذا، إنه إذا التي أثبتت إن الطفل عنده خلل
+
+970
+01:32:46,100 --> 01:32:52,340
+وراثي معين، أو مرض معين سيء، وعامل مشكلة، إن أنا ممكن
+
+971
+01:32:52,340 --> 01:32:58,000
+أعمل إجهاض، وأخلص منه. فبيهمني إن أنا أشخص، طبعًا،
+
+972
+01:32:58,000 --> 01:33:01,820
+واحد بدخل في جوانب أخلاقية، بيضل يدخل فيها قضية إنه،
+
+973
+01:33:01,820 --> 01:33:06,540
+طب شو عرفك؟ يعني لو إنسان عنده مرض منغولية، Down
+
+974
+01:33:06,540 --> 01:33:12,720
+Syndrome، يعني أنت هيك من برا بتقول هو المعذب، هو
+
+975
+01:33:12,720 --> 01:33:20,380
+بتعذّبه، هو مريض. يعني تقريبًا زي ما النازيين في
+
+976
+01:33:20,380 --> 01:33:25,260
+ألمانيا، قرروا أنه يعني خلصوهم من معاناتهم، وقتلوهم،
+
+977
+01:33:25,260 --> 01:33:30,580
+كلهم، ويعني يتبحوا أي واحد عنده مثل هذا الأشياء.
+
+978
+01:33:30,580 --> 01:33:35,720
+وكذلك يعني، قضية أنه في فترة الحمل ممكن أحيانًا،
+
+979
+01:33:35,720 --> 01:33:43,540
+يكون عندنا يعني آليات للتعامل، ممكن إجهاض، ممكن
+
+980
+01:33:43,540 --> 01:33:49,660
+مثلًا الطفل جنين، وعنده congenital heart disease،
+
+981
+01:33:49,660 --> 01:33:56,480
+وعنده ما هو اسمه؟ اللي ممكن يجرو له عملية وهو لسه
+
+982
+01:33:56,480 --> 01:34:01,370
+جنين. في بعض المرات مثلًا «هيدروبس فيتاليس»، وصار
+
+983
+01:34:01,370 --> 01:34:08,670
+عنده تكسر دم، بنقوله «للجنين في بطن أمه دم»، يعني
+
+984
+01:34:08,670 --> 01:34:14,290
+مرات بتكون فيه خيارات ممكن أعملها، حسب الحالة، وحسب
+
+985
+01:34:14,290 --> 01:34:18,310
+الـ «حسب
+
+986
+01:34:18,310 --> 01:34:22,350
+الوضع»، يعني طبعًا مع العائلة، «شو صار معاهم؟» «إيش
+
+987
+01:34:22,350 --> 01:34:30,980
+نحن بنتكلم؟» والفكرة أنه أنا لما أقول بعمل تفتيش
+
+988
+01:34:30,980 --> 01:34:38,540
+على شيء معين، بقول بعمله Screening. من الأشياء اللي
+
+989
+01:34:38,540 --> 01:34:44,460
+مثلًا يعني كويسة، وممكن أحيانًا أعملها. إحنا راح نحكي
+
+990
+01:34:44,460 --> 01:34:47,960
+على شو الأشياء اللي ممكن أعملها. خلينا بعد شوية
+
+991
+01:34:47,960 --> 01:34:55,810
+بنرجع للـ Slide اللي قبل، الـ Slide هذا اللي هو رقم
+
+992
+01:34:55,810 --> 01:35:04,950
+17-1، Figure 17-1، بيحكينا عن ثلاث أنواع من أنواع
+
+993
+01:35:04,950 --> 01:35:10,350
+الفحوصات اللي أستخدمها كـ Screening عند الحمل، عشان
+
+994
+01:35:10,350 --> 01:35:15,490
+أشوف الطفل مصاب أو غير مصاب، أو الجنين مصاب أو غير
+
+995
+01:35:15,490 --> 01:35:22,270
+مصاب. الجنين، اللي لسه هو مرحلة الجنين. الـ A، اللي هو
+
+996
+01:35:22,270 --> 01:35:29,470
+مسمّينه «Amniotic fluid sampling»، ماشي؟ الـ
+
+997
+01:35:29,470 --> 01:35:33,710
+«Amniocentesis».
+
+998
+01:35:33,710 --> 01:35:38,550
+هيك يسميه، الـ «Parietal synthesis» أو كده، اللي هي
+
+999
+01:35:38,550 --> 01:35:45,810
+يعني البزل، أو اللي صاحب العينة. فالمثال الأول A، إنه
+
+1000
+01:35:45,810 --> 01:35:54,220
+أنا باجي بالـ «Ultrasound» Guided، بدخل نيدل في بطن
+
+1001
+01:35:54,220 --> 01:36:01,360
+الأم، ببعد عن الجنين، ببعد عن المشيمة، ببعد عن أي
+
+1002
+01:36:01,360 --> 01:36:07,320
+شيء بيخوف، وبدخل النيدل في الـ Fluid المحيط
+
+1003
+01:36:07,320 --> 01:36:12,440
+بالجنين، وبأخذ منه خلايا، بأخذ منه Fluid، في
+
+1004
+01:36:12,440 --> 01:36:19,290
+الغالب Fluid، بكون بقدر أفحصه للأشياء هذه. مثلًا، زي
+
+1005
+01:36:19,290 --> 01:36:22,830
+الـ Chemical نتائج، زي الـ Alpha-Fetoprotein، راح
+
+1006
+01:36:22,830 --> 01:36:28,250
+نحكي عنه. الـ Chromosome الـ الـ الـ Components الـ
+
+1007
+01:36:28,250 --> 01:36:31,930
+Chromosome، الـ Enzyme Parameters، و الـ DNA
+
+1008
+01:36:31,930 --> 01:36:38,490
+Analysis. ممكن أبعثها لأشياء كثيرة. هنا الـ يعني هذه
+
+1009
+01:36:38,490 --> 01:36:45,130
+مشتركة، وجزء منها ممكن يعني هو في الغالب من الـ
+
+1010
+01:36:46,770 --> 01:36:51,450
+الجنين نفسه، بس إيه له ارتباط بالأم، وفيه ارتباط
+
+1011
+01:36:51,450 --> 01:36:56,270
+يعني، ممكن الـ Fluid هذا أقدر أفحص فيه أشياء، وفي
+
+1012
+01:36:56,270 --> 01:37:01,270
+أحيان ما أقدرش أفحص فيه أشياء ثانية، يعني حسب شو
+
+1013
+01:37:01,270 --> 01:37:07,230
+المشكلة، وأنا كيف أفحص، هل هذا الـ Sample مناسب لهذا
+
+1014
+01:37:07,230 --> 01:37:12,650
+الفحص ولا لأ؟ الطريقة الثانية، اللي هي Chorionic
+
+1015
+01:37:12,650 --> 01:37:20,610
+Villi Sampling. هنا أنا بدي آخذ من الـ villi تبع
+
+1016
+01:37:20,610 --> 01:37:25,990
+الكوريون، اللي هي برضه من الجنين، بس أنا بأخذ cells
+
+1017
+01:37:25,990 --> 01:37:35,330
+أكثر، cells يعني أنا متأكد إنها من الجنين، وبتكون
+
+1018
+01:37:35,330 --> 01:37:41,630
+أحسن إن أفحص عليها، زي كروموزومات، زي جينات، زي
+
+1019
+01:37:41,630 --> 01:37:47,140
+أشياء. فالـ الـ الـ الـ هنا العيب أو الملاحظة، أن أنا
+
+1020
+01:37:47,140 --> 01:37:51,800
+بدي أضطر آخذ من المشيمة نفسها، فأنا بدي آخذ
+
+1021
+01:37:51,800 --> 01:37:55,940
+المشيمة، يعني المشيمة ممكن تنزف، ممكن يكون فيها
+
+1022
+01:37:55,940 --> 01:38:02,180
+مشكلة، ممكن أنا أخرّب في الحالة هذه، فهذا موضوع أُعقد،
+
+1023
+01:38:02,180 --> 01:38:08,100
+فهنا زي ما أنتم شايفين، الـ Sonar حاطينه من فوق، والـ
+
+1024
+01:38:08,100 --> 01:38:17,160
+«حاطين»، بحطه يعني «سيرنج»، أو Wire، «كانيولا»، عشان
+
+1025
+01:38:17,160 --> 01:38:22,140
+أنا أدخل لجوة أكثر، وبعدين بأخذ الـ «سامبل»، حيث أنا
+
+1026
+01:38:22,140 --> 01:38:26,840
+أكون متأكد إن أنا واصل، مش بس بالـ «سونار» عمياني،
+
+1027
+01:38:26,840 --> 01:38:30,840
+هيك على الـ «أمنوسنتيسيس».
+
+1028
+01:38:30,840 --> 01:38:34,340
+لأ، أنا هنا ببدأ أصل لهذه المكان، للـ «بلاسنتا»،
+
+1029
+01:38:34,340 --> 01:38:41,800
+للمشيمة، وببدأ آخذ عينة منها. هذا أسلوب ثاني أحصل
+
+1030
+01:38:41,800 --> 01:38:48,860
+Sample من الجنين، عشان أقدر أعمل دراسات معينة.
+
+1031
+01:38:48,860 --> 01:38:56,080
+الموضوع الثالث اللي هو مربوط بإنه أنا الأيام هذه،
+
+1032
+01:38:56,080 --> 01:38:58,560
+تعرفوا كلكم، اللي هو موضوع الـ In Vitro
+
+1033
+01:38:58,560 --> 01:39:05,260
+Fertilization، التلقيح خارج الجسم، خارج الرحم، أو في
+
+1034
+01:39:05,260 --> 01:39:11,520
+المختبر. التلقيح هذا بدأ من خلال النساء اللي عندهم
+
+1035
+01:39:11,520 --> 01:39:15,800
+مثلًا سِدّ في القنوات، Fallopian tubes، أو أنابيب
+
+1036
+01:39:15,800 --> 01:39:20,940
+مسدودة. فعندها الـ الـ عندها الـ egg طبيعي، والرحم
+
+1037
+01:39:20,940 --> 01:39:27,120
+طبيعي، من ناحية ثانية، والمبايض كويسة، والزلمة كويس، بس الـ
+
+1038
+01:39:27,120 --> 01:39:32,620
+Sperm ما بيقدر يصل للـ egg، فبناخد الـ egg برا، وبن...
+
+1039
+01:39:32,620 --> 01:39:37,360
+شو اسمه؟ بنعرضها للـ Sperms، وبصير الـ Fertilization،
+
+1040
+01:39:37,360 --> 01:39:44,100
+وأنا في المختبر. يعني عادةً هذه الشغل بالـ In vitro
+
+1041
+01:39:44,100 --> 01:39:50,260
+fertilization، اللي لما يكون عندهم في الـ Petri dish،
+
+1042
+01:39:50,260 --> 01:39:55,180
+أو في الـ Cell culture medium، بيقدر الواحد تحت
+
+1043
+01:39:55,180 --> 01:39:58,900
+المايكروسكوب يشوف تطور البني آدم. تبدأ خلية واحدة،
+
+1044
+01:39:58,900 --> 01:40:03,520
+تنقسم خليتين، أربعة، ثمانية، ستة عشر. بصير doubling،
+
+1045
+01:40:03,520 --> 01:40:07,700
+doubling، doubling كل يوم، وبصير يعني متوقع مثلًا،
+
+1046
+01:40:07,700 --> 01:40:14,740
+ولها أسماء، لـ Blastomere مثلًا، بنستنى لما تصير
+
+1047
+01:40:14,740 --> 01:40:19,100
+الخلايا ثمان خلايا، يعني بيكون في مرحلة معينة، وهذا
+
+1048
+01:40:19,100 --> 01:40:26,140
+كله لسه قبل ما نرجع الطفل أو الجنين للرحم في الأم،
+
+1049
+01:40:26,140 --> 01:40:33,090
+أن آخذ خلية من هذه الخلايا، ماشي؟ أحيانًا بعد ما
+
+1050
+01:40:33,090 --> 01:40:36,030
+يصير الـ Implantation، أو إذا هذه بتصير يعني،
+
+1051
+01:40:36,030 --> 01:40:40,590
+بيستنوا عليها أكثر جوا الـ Test tube، لأنه بتصير
+
+1052
+01:40:40,590 --> 01:40:45,150
+على شكل كرة، وهذه
+
+1111
+01:45:34,580 --> 01:45:41,870
+إذا كان فيه Still Birth أو وفاة الحمل نفسه في حالة
+
+1112
+01:45:41,870 --> 01:45:46,810
+الـ Twin Pregnancies إذا أنا مش منتبه وكان فيه
+
+1113
+01:45:46,810 --> 01:45:53,610
+حمل توأم وبالتالي كمية الحمل أكبر وبالتالي الـ
+
+1114
+01:45:53,610 --> 01:45:57,730
+Alpha-Fetoprotein ممكن يكون مُتَوَقَّع أعلى Fetal
+
+1115
+01:45:57,730 --> 01:46:01,570
+Anomalies مثل هذه الأنواع برضه بيرتفع
+
+1116
+01:46:03,930 --> 01:46:08,910
+في أشياء دائماً ممكن تكون مجهولة أو الـ
+
+1117
+01:46:08,910 --> 01:46:15,090
+«overestimation of gestational age» يعني شكله
+
+1118
+01:46:15,090 --> 01:46:22,070
+كل ما … يعني هنا إذا بنعتبره مرتفع فكان لأنه إحنا
+
+1119
+01:46:22,070 --> 01:46:27,440
+هي مثلاً أنا فكرت حامل بالشهر الثالث وهو أنا المفروض
+
+1120
+01:46:27,440 --> 01:46:32,740
+يكون بدأ ينزل الـ Alpha-Fetoprotein وأنا بفكرها هي
+
+1121
+01:46:32,740 --> 01:46:38,960
+بالشهر مثلاً السادس فهي حقيقة بالثالث وبعدها بكون
+
+1122
+01:46:38,960 --> 01:46:45,000
+أعلى من الطبيعي فممكن يكون بأنه أنا كان فيه خطأ في تقدير
+
+1123
+01:46:45,000 --> 01:46:52,720
+الحمل لما أخذناها وبالتالي يعني دائماً صحيح أننا
+
+1124
+01:46:52,720 --> 01:46:56,480
+سوينا الـ procedure وعلى ضوئه، سأقول إن هذا مرتفع
+
+1125
+01:46:56,480 --> 01:47:00,220
+والله، يمكن الـ Neuronal Tube Defect «خليني أخلص
+
+1126
+01:47:00,220 --> 01:47:04,020
+منه» «ما بدي الحمل لأنه راح يغلب ويغلب وعنده
+
+1127
+01:47:04,020 --> 01:47:09,420
+المرض» وممكن يطلع إن هذه القراءة هي الغلط، مش أن
+
+1128
+01:47:09,420 --> 01:47:15,680
+الحالة فيها غلط فلما
+
+1129
+01:47:15,680 --> 01:47:20,340
+نعمل هنا، يعني النقطة الثانية اللي بنتكلم عنها اللي
+
+1130
+01:47:20,340 --> 01:47:26,080
+هي أنه لما بأخذ من الـ Placenta أو الـ Chorionic villi
+
+1131
+01:47:26,080 --> 01:47:30,320
+Sampling بأخذ  بيقوس الـ Tertiary Chorionic villi
+
+1132
+01:47:30,320 --> 01:47:37,600
+يعني بدي آخذ جانب معين يعني اللي هنا هي الكيس
+
+1133
+01:47:37,600 --> 01:47:43,580
+الحمل هنا الجنين
+
+1134
+01:47:43,580 --> 01:47:51,660
+نفسه والطبقات تبعته وبعدين هنا زي اللي بدي أعمل
+
+1135
+01:47:51,660 --> 01:47:55,480
+الـ Placenta أو بدي أعمل كده فببدأ أروح على مكان
+
+1136
+01:47:55,480 --> 01:48:00,640
+محدد عشان آخذ منه الـ Connective tissues اللي
+
+1137
+01:48:00,640 --> 01:48:05,220
+فيه الـ Cells تبع الجنين والـ Blood vessels وأعمل
+
+1138
+01:48:05,220 --> 01:48:16,460
+الفحص عليه، بظل أنه لما يكون في عندنا Machine فيه
+
+1139
+01:48:16,460 --> 01:48:23,760
+Interaction بين الأم والجنين يعني دائماً في الولادة
+
+1140
+01:48:23,760 --> 01:48:27,920
+وخلال الحمل بيصير اختلاط بين خلايا الأم وبين خلايا
+
+1141
+01:48:27,920 --> 01:48:28,720
+الجنين
+
+1142
+01:48:31,480 --> 01:48:38,440
+حول الجنين، فيه الـ Cytotrophoblast و نوع
+
+1143
+01:48:38,440 --> 01:48:42,080
+ثاني من الـ Trophoblast وفيه الـ Maternal blood و
+
+1144
+01:48:42,080 --> 01:48:46,360
+Maternal Sinusoid وفيه الـ Veins و الـ Capillaries
+
+1145
+01:48:46,360 --> 01:48:50,640
+و الـ Arteries تبع الجنين نفسه فكلها بتشترك
+
+1146
+01:48:50,640 --> 01:48:55,780
+مع بعض حتى support the patient أو support
+
+1147
+01:48:55,780 --> 01:49:00,320
+الجنين في الحالة
+
+1148
+01:49:00,320 --> 01:49:00,580
+هذه
+
+1149
+01:49:03,870 --> 01:49:08,090
+من الأشياء اللي بنقدر نعملها، فإحنا حكينا ممكن
+
+1150
+01:49:08,090 --> 01:49:12,770
+Amniotic Fluid Sampling ممكن Villus Sampling
+
+1151
+01:49:12,770 --> 01:49:19,190
+لأشياء أخرى ممكن في الـ «إن فيترو» آخذ يعني sample
+
+1152
+01:49:19,190 --> 01:49:23,850
+من الـ «بلاستومير»
+
+1153
+01:49:23,850 --> 01:49:27,770
+قبل حتى، من الأشياء المفيدة وكمان ممكن واحد يدور
+
+1154
+01:49:27,770 --> 01:49:31,730
+على أشياء معينة إذا كان واحد عنده خبرة اللي هو الـ
+
+1155
+01:49:31,730 --> 01:49:35,090
+Ultrasonography الـ Prenatal Diagnostic
+
+1156
+01:49:35,090 --> 01:49:39,810
+Ultrasonography الـ Sonar يعني عادةً بتعرفوا
+
+1157
+01:49:39,810 --> 01:49:43,730
+بيدوروا عادةً على الـ Heartbeat يشوفوا الـ إذا ذكروا
+
+1158
+01:49:43,730 --> 01:49:49,430
+الأنثى يشوفوا الـ External Genitalia بالنسبة للجنين،
+
+1159
+01:49:49,430 --> 01:49:53,710
+أشياء معينة، فدول يعني اللي هم العادي، الـ Sonar
+
+1160
+01:49:53,710 --> 01:49:58,670
+العادي اللي عادةً أطباء النساء بيعملوه يعني
+
+1161
+01:49:58,670 --> 01:50:05,600
+بيدوروا على أشياء معينة فيه بالنسبة لـ الـ يعني
+
+1162
+01:50:05,600 --> 01:50:08,880
+الـ other types of diseases that also can be
+
+1163
+01:50:08,880 --> 01:50:11,860
+diagnosed بس بيكون اللي بيعمل الـ sonar يعني
+
+1164
+01:50:11,860 --> 01:50:17,140
+experienced وبيعرَف على إيش بيدور وعن إيش بيدور وشو
+
+1165
+01:50:17,140 --> 01:50:21,680
+اللي بيدور عليه ففي مرات single gene disorders
+
+1166
+01:50:21,680 --> 01:50:25,860
+دول أسماؤهم ممكن بالـ sonar يعني الـ
+
+1167
+01:50:25,860 --> 01:50:29,040
+infantile polycystic kidney disease اللي هو الـ
+
+1168
+01:50:29,040 --> 01:50:32,380
+Polycystic Kidney Disease أنا عادةً بشوفهم لـ Adult
+
+1169
+01:50:32,380 --> 01:50:36,000
+Polycystic Kidney Disease بيكون بيبين بعدين ففي
+
+1170
+01:50:36,000 --> 01:50:40,200
+Severe Form وبيكون بيدخل فيه Renal Failure وكذا وكذا
+
+1171
+01:50:40,200 --> 01:50:45,220
+من الولادة وفي فترة سريعة كثيراً وبيكون فيه Multiple
+
+1172
+01:50:45,220 --> 01:50:50,200
+Cysts على الـ Kidneys بتبين في الجنين خلال الـ
+
+1173
+01:50:50,200 --> 01:50:55,660
+Ultrasonography حتى في الحمل، Disorders هدول أمثلة
+
+1174
+01:50:55,660 --> 01:50:58,740
+على Single Gene Disorders فيه أمثلة أخرى من الـ Disorders
+
+1175
+01:50:58,740 --> 01:51:03,800
+مثلاً «Cleft lip»، «Club foot»،
+
+1176
+01:51:03,800 --> 01:51:06,220
+«Congenital Heart Disease»، «Neuronal Tube
+
+1177
+01:51:06,220 --> 01:51:12,080
+Defect»، حكينا عنهم، هدول كلهم موجودة وفي مرات
+
+1178
+01:51:12,080 --> 01:51:16,680
+إذا في أشياء معينة، ممكن تخليني أشك في سندروم معين،
+
+1179
+01:51:16,680 --> 01:51:21,080
+الـ «Abnormal Genitalia»، «Cystic Hygroma»، اللي
+
+1180
+01:51:21,080 --> 01:51:25,040
+هو يعني نوع من الورم مع الوجه، ضخم ويكون له شكل
+
+1181
+01:51:25,040 --> 01:51:29,930
+معين، عدد الأصابع الـ Polydactyly و Syndactyly دي
+
+1182
+01:51:29,930 --> 01:51:33,570
+الأصابع ملتصقة ببعض طبعاً بدي يكون على مستوى معين
+
+1183
+01:51:33,570 --> 01:51:37,730
+من تطور الجنين، الـ Omphalocele هذا اللي على
+
+1184
+01:51:37,730 --> 01:51:43,330
+البطن بيصير فيه يعني defect معين، الـ Radial Ray
+
+1185
+01:51:43,330 --> 01:51:53,520
+Defect أشياء معينة، فالـ هنا يعني الـ Sonography في
+
+1186
+01:51:53,520 --> 01:51:59,600
+مرات بتخليني أكتشف أشياء كثيرة وبرضه ممكن تعمل
+
+1187
+01:51:59,600 --> 01:52:05,260
+فإحنا يعني على قول اللي بيسأل هذا مطلوب ولا مش
+
+1188
+01:52:05,260 --> 01:52:14,100
+مطلوب، كأرقام وقد إيش النسب وكده وكده، لأ، ما بدي،
+
+1189
+01:52:14,100 --> 01:52:19,700
+بس الفكرة إنه الـ Sonography ممكن تكون simple، non-
+
+1190
+01:52:19,700 --> 01:52:25,930
+invasive، easy to do بس بِتحتاج experience بِتحتاج واحد
+
+1191
+01:52:25,930 --> 01:52:31,670
+فاهم حتى يستثنى الموضوع يعني من القصص المشهورة
+
+1192
+01:52:31,670 --> 01:52:37,630
+جداً مثلاً ييجوا عائلة يقولوا والله جابت خمس بنات
+
+1193
+01:52:37,630 --> 01:52:41,610
+وهسه بالحمل السادس وييجوا واحد تبع Sonar ما
+
+1194
+01:52:41,610 --> 01:52:46,670
+بيفهمش ييجوا شاف وقال له هذا Female ممكن تطلع
+
+1195
+01:52:46,670 --> 01:52:50,560
+بالأخير Male يعني ممكن يكون بيطلع عنده بيطلع ولد
+
+1196
+01:52:50,560 --> 01:52:55,540
+يعني بالعكس يعني ففي مرات مشاكل إنه درجة خبرة
+
+1197
+01:52:55,540 --> 01:53:00,960
+الإنسان اللي بيقوم يعني الـ «الألتراساوند» is as good
+
+1198
+01:53:00,960 --> 01:53:07,340
+as الـ person doing it حاطين بالكتاب بصراحة ما
+
+1199
+01:53:07,340 --> 01:53:11,460
+جبتهاش لأن أنا مش عارف أشرح عليها بفهمش فيها ومش
+
+1200
+01:53:11,460 --> 01:53:17,080
+تخصصي ومش خبير فيها حاطين صور اللي هي أمثلة على
+
+1201
+01:53:17,080 --> 01:53:21,180
+الحالات هذه وكيف إنها بتبين بالـ Ultrasound وممكن
+
+1202
+01:53:21,180 --> 01:53:32,100
+شخصها من خلالها ففي عندنا قضية إنه كل ما بشوف مشاكل
+
+1203
+01:53:32,100 --> 01:53:38,160
+أكثر في الـ Ultrasound معناته الـ Abnormal
+
+1204
+01:53:38,160 --> 01:53:42,570
+Karyotype أو إن المشكلة أعقد، الـ Karyotype نتذكر من
+
+1205
+01:53:42,570 --> 01:53:47,270
+الـ previous lectures لما نتكلم على huge area سواء
+
+1206
+01:53:47,270 --> 01:53:52,190
+chromosomal defect هذه بقدر أُقَيِّمها بالـ Karyotype
+
+1207
+01:53:52,190 --> 01:53:57,470
+أو large chromosome segment سواء deletion،
+
+1208
+01:53:57,470 --> 01:54:02,870
+translocation، الـ other things فإيش بيكون بالـ
+
+1209
+01:54:02,870 --> 01:54:08,320
+Abnormal Karyotype معناته huge problem، الفكرة اللي
+
+1210
+01:54:08,320 --> 01:54:12,620
+لما يكون الـ Karyotype Problem يعني أنا بحكي مرة
+
+1211
+01:54:12,620 --> 01:54:17,100
+ثانية، كنا قضينا الـ Down Syndrome اللي هو خمس
+
+1212
+01:54:17,100 --> 01:54:22,240
+وثلاثين مظهر يعني مش بس العيون والأيادي والطول
+
+1213
+01:54:22,240 --> 01:54:25,320
+والـ Mental Retardation والـ Delayed Development
+
+1214
+01:54:25,320 --> 01:54:29,320
+والـ Heart Disease والـ Duodenal Atresia والكذا
+
+1215
+01:54:29,320 --> 01:54:33,780
+والكذا والكذا، كله بتلاقيه بيخربط أشياء كثيرة بالسبب
+
+1216
+01:54:33,780 --> 01:54:41,740
+إنه هي عدد كبير من الجينات مش single gene، فتطوير
+
+1217
+01:54:41,740 --> 01:54:47,960
+أكثر للـ Sonar وفي عندنا مثلاً إذا أحد منكم حتى
+
+1218
+01:54:47,960 --> 01:54:52,920
+بيقدر يتابع أو بيعرف في دكتور عندنا اسمه خالد
+
+1219
+01:54:52,920 --> 01:54:57,420
+سالينة، Pediatric Cardiologist، الـ Pediatric
+
+1220
+01:54:57,420 --> 01:55:05,520
+Cardiologists اللي هما الـ الـ الـ
+
+1221
+01:55:05,520 --> 01:55:06,420
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1222
+01:55:06,420 --> 01:55:06,500
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1223
+01:55:06,500 --> 01:55:06,900
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1224
+01:55:06,900 --> 01:55:07,740
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1225
+01:55:07,740 --> 01:55:10,240
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1226
+01:55:10,240 --> 01:55:11,380
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1227
+01:55:11,380 --> 01:55:16,220
+الـ الـ
+
+1228
+01:55:16,220 --> 01:55:17,660
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1229
+01:55:22,580 --> 01:55:27,620
+إن يصير إجهاض ويبدأ عملية إجهاض وكذا بس أحياناً
+
+1230
+01:55:27,620 --> 01:55:31,160
+في مرحلة متأخرة من الحمل وإن ده الوضع كويس للأم
+
+1231
+01:55:31,160 --> 01:55:38,280
+وأشيء simple و easy مش معقد، ممكن يعني يعملوا عملية
+
+1232
+01:55:38,280 --> 01:55:44,140
+على الجنين، technicalities بعرفهاش كتير، فمن الأشياء
+
+1233
+01:55:44,140 --> 01:55:48,100
+اللي بتدرسنا الموضوع هذا إنه أنا أعمل fetal
+
+1234
+01:55:48,100 --> 01:55:53,990
+echocardiography من خلال الـ ECO اللي هو تبع فحص
+
+1235
+01:55:53,990 --> 01:56:00,910
+صدر القلب بنشوف الجنين وبنشوف
+
+1236
+01:56:00,910 --> 01:56:08,170
+شو المشكلة اللي عنده، فهنا حاطط لكم بالأول نسب شو
+
+1237
+01:56:08,170 --> 01:56:11,150
+إحتمالية إنه فيه congenital heart disease في اللي
+
+1238
+01:56:11,150 --> 01:56:16,110
+عنده هذا المرض، هو هنا الـ Maternal Indications إذا
+
+1239
+01:56:16,110 --> 01:56:21,270
+الأم عندها type 1 diabetes mellitus اللي هو
+
+1240
+01:56:21,270 --> 01:56:24,470
+insulin dependent، الـ congenital heart disease
+
+1241
+01:56:24,470 --> 01:56:32,150
+بالجنين 3% لـ 5%، إذا بيكون 15%، Teratogen exposure
+
+1242
+01:56:32,150 --> 01:56:35,830
+نسبة أعلى، الـ Thalidomide مشهور هذا، بتعرفوا قصته
+
+1243
+01:56:35,830 --> 01:56:42,270
+الـ Thalidomide دواء يعني بالخمسينات والستينات
+
+1244
+01:56:42,270 --> 01:56:50,800
+بالأول عبارة عن دواء جيد جداً لـ Nausea وأحياناً
+
+1245
+01:56:50,800 --> 01:56:56,700
+بالذات مرضى الصُّلْعة أو مرضى أمراض كثيرة ممتاز جداً
+
+1246
+01:56:56,700 --> 01:57:00,840
+جداً جداً من أحسن الأدوية اللي ممتاز جداً جداً
+
+1247
+01:57:00,840 --> 01:57:07,080
+فيه الثاليدومايد اللي هو للحمل، فمعروف الحوامل
+
+1248
+01:57:07,080 --> 01:57:09,660
+بيستفرغوا
+
+1249
+01:57:12,820 --> 01:57:16,920
+الـ Hyperemesis Gravidarum بيسموه هذا من أحلى
+
+1250
+01:57:16,920 --> 01:57:21,480
+الأدوية وأحسن الأدوية له، كان له شعبية كبيرة بأمريكا
+
+1251
+01:57:21,480 --> 01:57:26,500
+رفضوا يدخلوه فإنتشر كثيراً في أوروبا، بعد إنتشار هذا
+
+1252
+01:57:26,500 --> 01:57:34,460
+الدواء بسنين وأشهر لاقوا إنه كثير صار أطفال يطلعوا
+
+1253
+01:57:34,460 --> 01:57:41,580
+من غير أيدين ولا رجلين، يعني كل الأطراف طايرة، وثبت إنه
+
+1254
+01:57:41,580 --> 01:57:48,100
+من تأثير الثاليدومايد، الآن للحوامل ممنوع
+
+1255
+01:57:48,100 --> 01:57:52,860
+خطر جداً ومع إنه يعني كان له شعبية بس لما ثبت إنه
+
+1256
+01:57:52,860 --> 01:57:59,060
+منه يعني، حبستوا الشركة وتغيّرت آراء الأطباء وكذا
+
+1257
+01:57:59,630 --> 01:58:06,190
+فالـ Thalidomide بنعرفه بطريقة معينة تقريباً مثلاً
+
+1258
+01:58:06,190 --> 01:58:10,650
+بس الـ Cancer أو الـ AIDS patient اللي بنعطيهم الـ
+
+1259
+01:58:10,650 --> 01:58:15,330
+Thalidomide لما يكونوا مش كويسين يعني فالـ
+
+1260
+01:58:15,330 --> 01:58:19,490
+Thalidomide لدى Cancer exposure له نسبة الـ
+
+1261
+01:58:19,490 --> 01:58:23,290
+Congenital Heart Disease 10%، الفينيتوين إذا كانت
+
+1262
+01:58:23,290 --> 01:58:29,010
+الأم بتأخذ Anti-epileptic الفينيتوين، وجود الكحول
+
+1263
+01:58:29,740 --> 01:58:32,580
+الـ Maternal Congenital Heart Disease بيزيد النسب
+
+1264
+01:58:32,580 --> 01:58:38,840
+هدول يعني أمراض عند الأم، المجموعة الثانية الـ
+
+1265
+01:58:38,840 --> 01:58:43,790
+Fetal Indications ممكن الـ Abnormal Fetal General
+
+1266
+01:58:43,790 --> 01:58:46,510
+Fetal Ultrasound Examination Results أو إذا
+
+1267
+01:58:46,510 --> 01:58:49,570
+إنتبهنا على الـ Arrhythmias لأنهم دائماً يبحثون على
+
+1268
+01:58:49,570 --> 01:58:54,870
+أن القلب بيبطئ بتحس أنه بيبطئ، الـ ECG ما بعرفش إذا
+
+1269
+01:58:54,870 --> 01:59:02,530
+بتقدروا، آه أظن بيحطوا الـ ECG للجنين وبيشوفوا الـ
+
+1270
+01:59:02,530 --> 01:59:05,690
+Arrhythmias تبعته، إذا بنعرف إنه فيه Chromosomal
+
+1271
+01:59:05,690 --> 01:59:09,330
+Anomalies بالذات الـ Down Syndrome، الـ Nuchal
+
+1272
+01:59:09,330 --> 01:59:13,770
+Thickening، الـ Non-Immune Hydrops Fetalis إذا صار
+
+1273
+01:59:13,770 --> 01:59:19,190
+تكسّر دم ممكن مع الـ Congenital Heart Disease أو
+
+1274
+01:59:19,190 --> 01:59:22,670
+إذا Family Syndrome زي الـ Mendelian Syndrome أو
+
+1275
+01:59:22,670 --> 01:59:25,850
+Paternal Congenital Heart Disease أو Previous Affected
+
+1276
+01:59:25,850 --> 01:59:33,530
+Child، كل مرة بتزيد فأحياناً يعني هي إختلالات في
+
+1277
+01:59:33,530 --> 01:59:38,030
+الأم، إختلالات في نفس الجنين أو إختلالات في عائلة
+
+1278
+01:59:38,030 --> 01:59:43,590
+الأم والعائلة والأسرة هذه في العائلة تخلينا نروح
+
+1279
+01:59:43,590 --> 01:59:50,630
+ندور على Eco-cardiography على فحص صدر القلب للجنين
+
+1280
+01:59:50,630 --> 01:59:54,750
+الفكرة
+
+1281
+01:59:55,650 --> 02:00:01,890
+نرجح هنا، يمكن كان مفروض حطيناها جنب تبع الأسباب
+
+1282
+02:00:01,8
+
+1333
+02:04:46,650 --> 02:04:52,570
+والنقطة اللي أضفناها قضية أن أنا ممكن أسحب دم من
+
+1334
+02:04:52,570 --> 02:04:59,990
+الأم ونتيجة اختلاط سواء الـ DNA لوحده من الجنين أو
+
+1335
+02:04:59,990 --> 02:05:04,830
+من خلايا الجنين مع خلايا الأم إنه في الدم ممكن
+
+1336
+02:05:04,830 --> 02:05:10,110
+أنا ألاقي مؤشرات على abnormalities معينة ممكن
+
+1337
+02:05:10,110 --> 02:05:13,970
+تفيدني مثل Alpha-Fetoprotein، فهنا حلاوة الـ
+
+1338
+02:05:13,970 --> 02:05:17,910
+Maternal Serum مثلًا، تجارب بشكل بسيط، بسهولة،
+
+1339
+02:05:17,910 --> 02:05:23,050
+وليست مهيجة للجنين، ولا تحصل على احتمالات مثل الـ
+
+1340
+02:05:23,050 --> 02:05:27,210
+Amniotic و Corionic Blood Sampling، لتعمل الـ
+
+1341
+02:05:27,210 --> 02:05:35,070
+Damage، فهذا يكون أسهل، لكن هذا النوع من التجارب
+
+1342
+02:05:35,290 --> 02:05:39,090
+فيه له محاذير كثيرة، ومرات ما بستفيدش منها في أشياء
+
+1343
+02:05:39,090 --> 02:05:42,630
+كثيرة، فالـ Alpha-Fetoprotein Concentration هذا الـ
+
+1344
+02:05:42,630 --> 02:05:47,170
+Maternal ممتاز وسهل وبسيط، وممكن يصيد أشياء كثيرة
+
+1345
+02:05:47,170 --> 02:05:51,290
+من
+
+1346
+02:05:51,290 --> 02:05:59,410
+الأشياء الثانية اللي بنعملها، اللي هي أنه ممكن
+
+1347
+02:05:59,410 --> 02:06:04,350
+أنا الـ Alpha-Fetoprotein اللي ذكرناها، في عندي
+
+1348
+02:06:04,350 --> 02:06:08,030
+الـ HCG اللي هو الـ Human Chorionic Gonadotropin
+
+1349
+02:06:08,030 --> 02:06:17,330
+تبع الحمل كهرمون، وفيه شيء اسمه N-HPNA، وفيه other
+
+1350
+02:06:17,330 --> 02:06:24,850
+يعني parameters زي ارتخاء الرقبة أو Nuclear
+
+1351
+02:06:24,850 --> 02:06:32,580
+Translucency، وفيه شيء اسمه اللي هو Human Chorionic
+
+1352
+02:06:32,580 --> 02:06:36,360
+Gonadotropin Beta-subunit أو الـ Pregnancy Associated
+
+1353
+02:06:36,360 --> 02:06:40,960
+Plasma Protein A  (PAPP-A)
+
+1354
+02:06:40,960 --> 02:06:45,240
+الفكرة أنه يعني هذه الأشياء هنا بفحصها هنا هي بالـ
+
+1355
+02:06:45,240 --> 02:06:56,880
+ultrasound، وهدول عن طريق الـ Maternal Serum، يعني
+
+1356
+02:06:56,880 --> 02:07:02,980
+بسحب الـ Serum تبعها، وهنا بحكي لكم أن أحيانًا أنا
+
+1357
+02:07:02,980 --> 02:07:07,440
+ممكن أشخص أشياء كثيرة إذا بشوف Anomalies بشكل
+
+1358
+02:07:07,440 --> 02:07:12,680
+معين، ماشي؟ فالـ Trisomy 21 (Down Syndrome) أو أكثر
+
+1359
+02:07:12,680 --> 02:07:18,660
+من واحد، بس ممكن 18 و 13، نسبهم أقل، وإذا فيه Neural
+
+1360
+02:07:18,660 --> 02:07:23,920
+Tube Defect برضه سيء، الـ Neural بالنسبة لنا بيفيد
+
+1361
+02:07:23,920 --> 02:07:28,410
+الطفل بيطلع طبيعي من فوق، يعني paraplegia يعني شلل
+
+1362
+02:07:28,410 --> 02:07:33,590
+بالنصف السفلي، بس مرات الـ Neural Tube Defect إذا
+
+1363
+02:07:33,590 --> 02:07:39,070
+من جهة اللي فوق، أنا انكفاء وأشياء ثانية ممكن تكون
+
+1364
+02:07:39,070 --> 02:07:42,590
+Very Very Severe، فهنا هاي إذا عائلة في عندها مشكلة
+
+1365
+02:07:42,590 --> 02:07:47,330
+ممكن شو اسمها؟ أفحص هذه الأشياء، وهنا بأفحصها بالـ
+
+1366
+02:07:47,330 --> 02:07:56,850
+First Trimester، ثلث الأول للحمل، من تسعة شهور أو
+
+1367
+02:08:01,550 --> 02:08:05,790
+الثلث الثاني، بلاقي إن بقدر أفحص على أشياء ثانية
+
+1368
+02:08:05,790 --> 02:08:10,410
+وبقدر من خلالهم أشخص أشياء معينة، الـ Alpha-Feto-
+
+1369
+02:08:10,410 --> 02:08:13,490
+Protein أهم واحد، وهذا اللي بدي إياه، وبيكون مع الـ
+
+1370
+02:08:13,490 --> 02:08:19,090
+Neural Tube Defect، البقية يعني تفاصيلها يعني
+
+1371
+02:08:19,090 --> 02:08:22,970
+حاطين شيء بيرتفع، شيء بينخفض، هذه بدأت تكون لـ
+
+1372
+02:08:22,970 --> 02:08:28,630
+Pediatrician أو Gynecologist (Obstetrician) تبع طبيب
+
+1373
+02:08:28,630 --> 02:08:32,970
+حوامل، إذا كان أثير موضوع إنه فيه كان طفل أول عنده
+
+1374
+02:08:32,970 --> 02:08:40,430
+مشكلة، والآن بقالنا طفل ثاني، من الأشياء المهمة اللي
+
+1375
+02:08:40,430 --> 02:08:49,830
+هي موضوع أنه الإنسان بنسميه Mosaic، الفكرة
+
+1376
+02:08:49,830 --> 02:08:58,240
+أنّه الإنسان لما يكون في بطن أمه في الحمل بيكون
+
+1377
+02:08:58,240 --> 02:09:06,900
+يعني الإنسان هو في مجال اختلاط الخلايا بين الأم
+
+1378
+02:09:06,900 --> 02:09:13,800
+وبين الجنين، فبالـ Peripheral blood للأم بيكون بعض
+
+1379
+02:09:13,800 --> 02:09:21,140
+الخلايا اجت من الجنين، فبالتالي هنا حاطين أسلوب معين
+
+1380
+02:09:21,140 --> 02:09:26,400
+للدراسة، اللي هو "Non-invasive prenatal screening"
+
+1381
+02:09:26,400 --> 02:09:33,920
+نسميه "NIPS" ("Non-invasive prenatal screening")، هنا
+
+1382
+02:09:33,920 --> 02:09:38,220
+إذا الواحد عنده جهاز قادر على أن يعمل هذا الشيء
+
+1383
+02:09:38,220 --> 02:09:47,680
+اللي راح يسوي إنه راح يسحب دم الأنثى بـ
+
+1384
+02:09:47,680 --> 02:09:53,710
+"peripheral blood"، معرفش هو من الـ Serum، بيعملوا
+
+1385
+02:09:53,710 --> 02:09:57,970
+License للـ Cells كلها، وبعدين بياخدوها كلها، المهم
+
+1386
+02:09:57,970 --> 02:10:03,030
+بيعملوا عزل للـ DNA تبع كل الأشياء اللي موجودة في الـ
+
+1387
+02:10:03,030 --> 02:10:07,610
+Serum، بالـ Maternal Serum، فالـ Cell-free DNA الـ
+
+1388
+02:10:07,610 --> 02:10:14,650
+Maternal Serum، هذا الغالبية العظمى جدًا منه من الأم
+
+1389
+02:10:14,650 --> 02:10:24,600
+بس بيظل الإنسان فيه عنده شوية DNA من الـ Fetus، يعني
+
+1390
+02:10:24,600 --> 02:10:32,960
+فيه يعني هذا مصطلح نستخدمه حتى في المناعة، نسميه
+
+1391
+02:10:32,960 --> 02:10:40,560
+لأن الإنسان is a chimera، chimera هو مخلوق يعني
+
+1392
+02:10:40,560 --> 02:10:46,580
+خيالي بالأساطير الرومانية واليونانية، إنه شخصين في
+
+1393
+02:10:46,580 --> 02:10:51,880
+جسم واحد، مرات بالرسوم المتحركة فيجيبولك راسين في
+
+1394
+02:10:51,880 --> 02:10:57,580
+جسم واحد، أو شخصين أو اثنين ملتصقين زي توائم سيامية
+
+1395
+02:10:57,580 --> 02:11:03,680
+أو الكايميرة نفسها، راس إنسان أو راس أسد، جسم أسد
+
+1396
+02:11:03,680 --> 02:11:08,680
+وراس إنسان، وديل حيوان، وإجران فيل، وخرطوم، مش عارف إيش
+
+1397
+02:11:08,680 --> 02:11:13,620
+زي الحيوان، يعني أنه من أكثر من جزء، فهنا اللي بيسووا
+
+1398
+02:11:13,620 --> 02:11:21,680
+أنه بعزلوا الـ DNA الـ Free في الـ Serum تبع الأم
+
+1399
+02:11:21,680 --> 02:11:29,020
+فشغلة، صحبة دم بسيطة، باجي بعمل اللي هو NGS اللي هو
+
+1400
+02:11:29,020 --> 02:11:37,880
+الـ Next Generation Sequencing، للواحد يعرف شو
+
+1401
+02:11:37,880 --> 02:11:43,420
+الأسماء، مرات معقدة الشغلة، هي يعني جهاز Sequencer
+
+1402
+02:11:43,420 --> 02:11:47,620
+يعني بيقرأ الـ Nucleotides بشكل سريع جدًا جدًا
+
+1403
+02:11:47,620 --> 02:11:53,480
+يعني فوق السرعة، بكمبيوتر سريع جدًا، الفكرة أنه لما
+
+1404
+02:11:53,480 --> 02:12:01,460
+نقرأ القطع هذه، ونكون عارفين عنها، بالأخير نقدر نعد
+
+1405
+02:12:01,460 --> 02:12:05,300
+شو هي الـ Copies، ومن أنه كروموزوم هذه القطعة اللي
+
+1406
+02:12:05,300 --> 02:12:09,680
+قرأناها، فهي يعني نوع من زي الـ Human Genome Project
+
+1407
+02:12:09,680 --> 02:12:15,360
+بس سريع جدًا جدًا، وبسرعة، الاهتمام هنا في المثال
+
+1408
+02:12:15,360 --> 02:12:22,800
+هذا إنه أشوف كم Copy من أي Chromosome، أنا بتكلم
+
+1409
+02:12:22,800 --> 02:12:26,720
+عنه، فالأصل ألاقي two chromosomes ones، two
+
+1410
+02:12:26,720 --> 02:12:29,960
+chromosomes two، كذا كذا، إذا لقيت three
+
+1411
+02:12:29,960 --> 02:12:35,040
+chromosomes twenty-two، ممكن أقول إنه عدد الـ Copies
+
+1412
+02:12:35,040 --> 02:12:40,550
+هنا أكثر، أو في  Unplied أو Uplied أو Duplied، إذا في
+
+1413
+02:12:40,550 --> 02:12:44,870
+سواء لـ One Chromosome أو كل الكروموزومات أو Half
+
+1414
+02:12:44,870 --> 02:12:49,010
+Chromosomes، يعني هل في One-End، Two-End، Three-
+
+1415
+02:12:49,010 --> 02:12:55,250
+End، Four-End، Six-End أو كده، فالفكرة
+
+1416
+02:12:55,250 --> 02:13:03,730
+الآن هو المثال اللي حطيناه هنا، يعني اللي بدل واحد
+
+1417
+02:13:03,730 --> 02:13:08,670
+ينتبه له أنه في أشياء يمكن يفضل تنعمل بالـ First
+
+1418
+02:13:08,670 --> 02:13:15,770
+Trimester، بس في أشياء ممكن نصير أه والله نقدر
+
+1419
+02:13:15,770 --> 02:13:20,130
+نستفيد منها أكثر لما نعملها بالثلاثة شهور التانية
+
+1420
+02:13:20,130 --> 02:13:25,070
+بين الشهر الرابع للسادس، إنه أنا بسوي المتابعة على
+
+1421
+02:13:25,070 --> 02:13:29,330
+أكثر من شهر، وعلى أكثر من محل، أني أدور على أي شيء
+
+1422
+02:13:29,330 --> 02:13:34,590
+معين، فهنا الـ Chimerism
+
+1423
+02:13:34,590 --> 02:13:40,610
+أو الـ Mosaicism، إنه الـ DNA من أكثر من مصدر، وأنا
+
+1424
+02:13:40,610 --> 02:13:48,850
+بروخ بشوف خواص الـ DNA تبع الجنين، وبحكم من خلاله
+
+1425
+02:13:48,850 --> 02:13:52,990
+على أنه فيه مشكلة في الجنين، وممكن أشخص أشياء معينة
+
+1426
+02:13:53,610 --> 02:13:57,690
+في مقابل أن هذا فحص بسيط وسهل، ومن الأم بسحب نتفة
+
+1427
+02:13:57,690 --> 02:14:03,690
+الدم، وبعطيه مؤشر شو الجنين عنده، وهذا بستخدم فيه
+
+1428
+02:14:03,690 --> 02:14:09,310
+NIPS، وبستخدم فيه NGS (Next Generation Sequencing)
+
+1429
+02:14:09,310 --> 02:14:18,510
+فحتى الفكرة، لما على الأقل هذا من خلال دراسة معينة
+
+1430
+02:14:18,510 --> 02:14:22,950
+طلعت سنة 2014، الـ New England Journal of Medicine
+
+1431
+02:14:22,950 --> 02:14:30,510
+أنه الـ First Trimester Triple Screen اللي حكينا
+
+1432
+02:14:30,510 --> 02:14:36,130
+عنه هنا، الـ  Nuchal Translucency و الـ PAPP-A و
+
+1433
+02:14:36,130 --> 02:14:43,830
+الـ free β-hCG، لا كذا، الـ Sensitivity 85% والـ
+
+1434
+02:14:43,830 --> 02:14:50,030
+False Positive Rate 5%، احنا بيهمنّا كل ما يكون هذا
+
+1435
+02:14:50,030 --> 02:14:56,190
+Sensitivity أكثر، و Specificity أقل، Sensitivity إن
+
+1436
+02:14:56,190 --> 02:15:00,050
+المريض اللي عنده مرض نطلع إنه فعلاً مريض
+
+1437
+02:15:00,050 --> 02:15:05,250
+و Specificity إنه سليم نطلع إنه سليم، يعني هنا
+
+1438
+02:15:05,250 --> 02:15:10,300
+العلاقة بينهم، عادةً العلاقة بينهم عكسية، كل ما
+
+1439
+02:15:10,300 --> 02:15:13,620
+بدأ أزود الـ Sensitivity بقلل الـ Specificity، هيك
+
+1440
+02:15:13,620 --> 02:15:18,620
+العلاقة على نفس الـ Test الواحد في الحالة الواحدة
+
+1441
+02:15:18,620 --> 02:15:22,480
+أما لما يكون عندي أكثر من شيء، وأسوي أشياء مختلفة
+
+1442
+02:15:22,480 --> 02:15:27,120
+الـ Non-invasive prenatal screening كله لما نعمله
+
+1443
+02:15:27,120 --> 02:15:33,820
+بالكامل، أكثر من 99% Sensitivity، وأقل من 1%
+
+1444
+02:15:33,820 --> 02:15:43,120
+Specificity، بس هذا برضه أرقام مهمة، فالفكرة أنه الـ
+
+1445
+02:15:43,120 --> 02:15:50,040
+Non-invasive Screening
+
+1446
+02:15:50,040 --> 02:15:57,420
+الأصل يكون هو الأول، وأنا يعني ممكن كـ Consultant
+
+1447
+02:15:58,030 --> 02:16:01,970
+ويجيني عائلة عندهم مشكلة أو عندهم حالة بدهم يسوي
+
+1448
+02:16:01,970 --> 02:16:07,770
+دراسة عليها، الأصل أنه بالأول أبدأ، أو يكون عندي خطة
+
+1449
+02:16:07,770 --> 02:16:12,850
+الطريق، خارطة الطريق، "شو بدي أعمل؟" بالترتيب، في
+
+1450
+02:16:12,850 --> 02:16:18,710
+كل حالة، فعادةً أو الأصل أو الأحسن أنه أبدأ بأنه
+
+1451
+02:16:18,710 --> 02:16:23,290
+أعمل Non-invasive Screening في الأول، وفي
+
+1452
+02:16:23,290 --> 02:16:27,650
+الثاني، وفي مش عارف إيش وكده، طبعًا حتى في
+
+1453
+02:16:27,650 --> 02:16:31,790
+الـ first trimester أو في مرحلة مبكرة ممكن أحتاج
+
+1454
+02:16:31,790 --> 02:16:36,230
+أحيانًا Chorionic Villus Sampling أو Amniocentesis أو
+
+1455
+02:16:36,230 --> 02:16:40,850
+الـ invasive testing، وممكن أني أصل في مرحلة أن
+
+1456
+02:16:40,850 --> 02:16:44,450
+أقول لأ والله الفحص negative، والأمور إن شاء الله
+
+1457
+02:16:44,450 --> 02:16:48,350
+سليمة، وأقولهم مافي داعي تقلقوا، إن شاء الله الأمور
+
+1458
+02:16:48,350 --> 02:16:53,350
+كويسة، و know that the testing is needed، مش ممكن
+
+1459
+02:16:53,350 --> 02:16:59,030
+نعمله، أو لأنه خلاص النتيجة طلعت إيجابية، فهي النقطة
+
+1460
+02:16:59,030 --> 02:17:09,470
+يعني كملخص للفصل هذا، إنه احنا لما نتعامل مع
+
+1461
+02:17:09,470 --> 02:17:18,900
+الأمراض الوراثية، في عندنا جوانب، بالأول بنسويه قبل
+
+1462
+02:17:18,900 --> 02:17:27,100
+ما قبل الزواج، أحيانًا أحيانًا يعني عند الولادة
+
+1463
+02:17:27,100 --> 02:17:31,060
+المفروض يكون فيه نوع من الـ Screening، ويكون للطفل
+
+1464
+02:17:31,060 --> 02:17:36,280
+سليم، وولادة طبيعية، برضه بعمل بعض الفحوصات عشان
+
+1465
+02:17:36,280 --> 02:17:41,840
+أستبعد بعض الأمراض، هدول ممكن سهلة وخفيفة، وعادة
+
+1466
+02:17:41,840 --> 02:17:46,280
+Simple، بس في حاجة، وهدول في الغالب يعني بنسميها
+
+1467
+02:17:46,280 --> 02:17:51,530
+Screening لـ General Population، للأمهات والناس، أما لما
+
+1468
+02:17:51,530 --> 02:17:56,370
+يصير عندي حالة، أنه عائلة عندهم مشكلة، وأنا كـ
+
+1469
+02:17:56,370 --> 02:18:01,830
+Consultant وكذا، وبيهمني أني أتأكد كيف أتعامل مع
+
+1470
+02:18:01,830 --> 02:18:05,310
+هذا الموضوع، وكل اللي بنحكي عنه Invasive و Non-
+
+1471
+02:18:05,310 --> 02:18:10,570
+invasive و Screening وكذا وكذا، في حالة إذا فكرة
+
+1472
+02:18:10,570 --> 02:18:15,560
+أنه يكون فيه Abortion أو نوع من الـ Abortion مقبول
+
+1473
+02:18:15,560 --> 02:18:19,740
+أو في حالة إن والله عندي إمكانيات أعمل والله رأيت
+
+1474
+02:18:19,740 --> 02:18:22,840
+الـ Congenital Heart Disease، أعمل جراحة للجنين في
+
+1475
+02:18:22,840 --> 02:18:29,320
+بطنه، فهذه يعني النقاط، المطلوب، المطلوب
+
+1476
+02:18:29,320 --> 02:18:35,740
+للـ Consultant أنه يكون عنده خارطة طريق بهذا
+
+1477
+02:18:35,740 --> 02:18:40,870
+المثال، بهذه الطريقة يكون منتبه، طبعًا يعني الـ
+
+1478
+02:18:40,870 --> 02:18:43,310
+"سلايد" اللي قبل شوية، "الخاصية" "الخاصية"
+
+1479
+02:18:43,310 --> 02:18:43,870
+"الخاصية" "الخاصية" "الخاصية" "الخاصية" "الخاصية"
+
+1480
+02:18:43,870 --> 02:18:44,630
+"الخاصية" "الخاصية" "الخاصية" "الخاصية" "الخاصية"
+
+1481
+02:18:44,630 --> 02:18:45,090
+"الخاصية" "الخاصية" "الخاصية" "الخاصية" "الخاصية"
+
+1482
+02:18:45,090 --> 02:18:45,510
+"الخاصية" "الخاصية" "الخاصية" "الخاصية" "الخاصية"
+
+1483
+02:18:45,510 --> 02:18:46,910
+"الخاصية" "الخاصية" "الخاصية" "الخاصية" "الخاصية"
+
+1484
+02:18:46,910 --> 02:18:49,170
+"الخاصية" "الخاصية" "الخاصية" "الخاصية" "الخاصية"
+
+1485
+02:18:49,170 --> 02:18:56,950
+"الخاصية"
+
+1486
+02:18:56,950 --> 02:19:01,330
+"الخاصية"
+
+1487
+02:19:01,680 --> 02:19:09,460
+والـ True Negative، لأنه يقدر يقود الأهل في هذه
+
+1488
+02:19:09,460 --> 02:19:16,140
+النقاط، من خلال كل الخيارات المتاحة سواء كـ
+
+1489
+02:19:16,140 --> 02:19:21,560
+Screening و Testing، وبعد ذلك كعلاج، فأظن هذا آخر
+
+1490
+02:19:21,560 --> 02:19:27,000
+Slide، أو لأ، في واحد الـ Mosaicism، يعني اللي هو
+
+1491
+02:19:27,000 --> 02:19:33,260
+أنه أحيانًا في نفس الطريق، يعني خلال نفس الحمل في
+
+1492
+02:19:33,260 --> 02:19:39,760
+مرحلة معينة، ممكن تصير بعض الـ ... الـ Mutations أو
+
+1493
+02:19:39,760 --> 02:19:50,240
+اختلالات بشكل معين، يعني أنه يكون يعني فيه اختلالات
+
+1494
+02:19:50,240 --> 02:19:58,700
+بشكل، يعني هنا، يعني أخذوا مثل الـ Diploid اللي هو
+
+1495
+02:19:58,700 --> 02:20:03,960
+الإنسان الطبيعي، خلايا تبعات الإنسان الطبيعي، خلايا
+
+1496
+02:20:03,960 --> 02:20:07,220
+الـ Diploid، إلا في الـ Aneuploids والـ Sperms
+
+1497
+02:20:07,220 --> 02:20:11,800
+الـ Aneuploid، يعني اللي هي مش طبيعية، باختلال بشكل
+
+1498
+02:20:11,800 --> 02:20:19,440
+معين، 3N، 4N أو 1N مثلًا، أو الـ Trisomy، شيء زي هيك
+
+1499
+02:20:19,440 -->
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ecLGirzn8pc_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ecLGirzn8pc_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..2ce0b5398877422d20189d47b4f5f6c1c8b56d8d
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ecLGirzn8pc_postprocess.srt
@@ -0,0 +1,6188 @@
+1
+00:00:00,000 --> 00:00:06,380
+إن شاء الله يعني كمعلومة للطلاب
+
+2
+00:00:06,380 --> 00:00:10,240
+إحنا إن شاء الله راح يكون جزء الأخير بنشوف آلية
+
+3
+00:00:10,240 --> 00:00:15,100
+كويسة نراجع فيها الأسئلة تبع الـUSMLE وCAPLAN
+
+4
+00:00:15,100 --> 00:00:22,060
+والمراجع اللي هي نوع معين international على أساس
+
+5
+00:00:22,060 --> 00:00:28,680
+يعني هو هذا معيار اللي نغطينا المادة إن شاء الله
+
+6
+00:00:28,680 --> 00:00:37,170
+نكوناستوعبته واستفدنا إن شاء الله الآن،
+
+7
+00:00:37,170 --> 00:00:43,150
+نحن ماشي لسه في الكتاب، ماضلش غير فصل أو فصلين بعد
+
+8
+00:00:43,150 --> 00:00:51,130
+ذلك، يعني بالذات بعتبر الـ Ethics تبع الـ Genetic
+
+9
+00:00:51,130 --> 00:00:55,690
+Counseling أو الاشي اللي بنعملها فيه جوانب أخلاقية
+
+10
+00:00:55,690 --> 00:01:00,500
+مهمة كثير، وهي أنا بعتبر مهمة من الواحديتناولها،
+
+11
+00:01:00,500 --> 00:01:06,280
+يعني هي بتظل محاضرة أو محاضرتين بعد اليوم وبعد ذلك
+
+12
+00:01:06,280 --> 00:01:14,500
+راح تكون نوع من مراجعة الأسئلة الآن
+
+13
+00:01:14,500 --> 00:01:20,640
+اليوم محاضرتين هما قريبات على بعض وقصيرات نوعًا ما
+
+14
+00:01:20,640 --> 00:01:24,040
+نتعامل
+
+15
+00:01:24,040 --> 00:01:31,660
+مع كيف بدنا نتعامليعني، ما هي الأليات؟ ما هي
+
+16
+00:01:31,660 --> 00:01:37,920
+الخطوات التي يجب أن تكون جهة معينة مسئولة في
+
+17
+00:01:37,920 --> 00:01:44,700
+الحكومة، في البلد أو في مستشفى تتعامل مع كيف ننصح
+
+18
+00:01:44,700 --> 00:01:50,080
+الأهالي والعائلات لما نكون عندنا احتمالية أمراض
+
+19
+00:01:50,080 --> 00:01:56,800
+ورافيةالآن فيه Two Chapters Today فيه Risk
+
+20
+00:01:56,800 --> 00:02:00,440
+Assessment وGenetic Counseling يعني شو بدنا نعمل
+
+21
+00:02:00,440 --> 00:02:05,260
+في الموضوع هذا وبعد ذلك في محاضرة اللي بعدها اللي
+
+22
+00:02:05,260 --> 00:02:11,380
+هي نسمينها Preterm أو Prenatal Diagnosis اللي هو
+
+23
+00:02:11,380 --> 00:02:19,840
+تشخيص ما قبل الولادة يعني حتى إذا في خيار أنه تعمل
+
+24
+00:02:19,840 --> 00:02:27,020
+علاجات معينة أنه نعملهافاليوم المحاضرة الأولى هي
+
+25
+00:02:27,020 --> 00:02:35,700
+على شو نعمل مع عائلة عندها احتمالية مرض وراثي شو
+
+26
+00:02:35,700 --> 00:02:40,280
+ننصحها، كيف ننصحها، على أي أساس ننصحها وكيف نتعامل
+
+27
+00:02:40,280 --> 00:02:45,100
+مع الموضوع هذا النقطة
+
+28
+00:02:45,100 --> 00:02:55,240
+الأولى يعني حاطين هنا ما يمثلقواعد عامة في التعامل
+
+29
+00:02:55,240 --> 00:02:59,200
+مع الـ Genetic Diseases
+
+30
+00:03:03,670 --> 00:03:08,170
+قسموا العائلة، يعني ممكن أي إنسان يكون عنده هيك
+
+31
+00:03:08,170 --> 00:03:12,830
+إذا بيشوف حد من أقاربه عنده حالة ورافية، ممكن هو
+
+32
+00:03:12,830 --> 00:03:17,510
+يتساءل جوا نفسه إنه هل أنا معرض أو أصاب بنفس المرض
+
+33
+00:03:17,510 --> 00:03:24,670
+بنفس الطريقة أو إذا عائلة أو زوجين عندهم واحد أو
+
+34
+00:03:24,670 --> 00:03:31,350
+في العائلة عندهم في مرض معين، بتكون يعني الواحد
+
+35
+00:03:31,350 --> 00:03:36,550
+هيك يقدرفهنا كقاعدة
+
+36
+00:03:36,550 --> 00:03:41,490
+عامة، خلّيني نخد بالآخر، بالأول والآخر واحدة تحت
+
+37
+00:03:41,490 --> 00:03:46,890
+كتبيلكم الـ Average Risk الإنسان العادي، يعني إحنا
+
+38
+00:03:46,890 --> 00:03:50,890
+قررنا عن أمراض كثيرة، بيصير الواحد أصلا مخه يلف
+
+39
+00:03:50,890 --> 00:03:55,030
+ويفكر إنه عنده واحد من هذه الأشياء أو ممكن يصيبه
+
+40
+00:03:55,030 --> 00:03:59,730
+أو ممكن يصيب ولاده ولا كده فالـ Average Risk اللي
+
+41
+00:03:59,730 --> 00:04:03,480
+هي زي الـ Risk in the general populationعندما يكون
+
+42
+00:04:03,480 --> 00:04:07,360
+هناك مصادر غير مصادر مصادر مصادر مصادر مصادر مصادر
+
+43
+00:04:07,360 --> 00:04:09,820
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+44
+00:04:09,820 --> 00:04:12,860
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+45
+00:04:12,860 --> 00:04:14,240
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+46
+00:04:14,240 --> 00:04:17,180
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+47
+00:04:17,180 --> 00:04:18,020
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+48
+00:04:18,020 --> 00:04:28,830
+مصادر مصادر مصادر مصادر مصادر مصادر مصاديعني هذه
+
+49
+00:04:28,830 --> 00:04:34,830
+نفس المعنى مش عارف ليش يعني بيحطها تكرار بس
+
+50
+00:04:34,830 --> 00:04:39,790
+التنتين بتعني إنه واحد ما عنده مثل هي حالة لما تصل
+
+51
+00:04:39,790 --> 00:04:44,990
+الأمور إلى إنه second degree relative يعني إنسان
+
+52
+00:04:44,990 --> 00:04:55,410
+ابن عم أو عم أو حدا بعيد أبعد شوية وشخص واحد بس
+
+53
+00:04:55,410 --> 00:05:01,260
+يعني مش عداد أكبربكون هذا الاحتمالية تعتبر يعني مش
+
+54
+00:05:01,260 --> 00:05:04,760
+أكتر من الـ General Population بشكل عام و هنشوف
+
+55
+00:05:04,760 --> 00:05:08,780
+أمثلة عليها أو في حالة ما بيصير عملية تبني
+
+56
+00:05:08,780 --> 00:05:15,660
+فالإنسان المتبنى ما له علاقة بالـ يعني بالما هو
+
+57
+00:05:15,660 --> 00:05:20,500
+معلوم عن العائلة من وجود أمراض وراثية فهذولة
+
+58
+00:05:20,500 --> 00:05:25,960
+Average Risk في المقابل الـ
+
+59
+00:05:27,710 --> 00:05:34,690
+عنا الـ group بتكون high risk إذا كان عندنا first
+
+60
+00:05:34,690 --> 00:05:40,210
+degree relative قريب من الدرجة الأولى وعرفناهم من
+
+61
+00:05:40,210 --> 00:05:45,310
+قبل اللي هم يعني الأب والأم والإخوان والولادة
+
+62
+00:05:45,310 --> 00:05:50,250
+والبنات، لأي واحد حوالينه أبعد من هيك بيصير second
+
+63
+00:05:50,250 --> 00:05:56,230
+degree وأبعد من ذلك third degreeفلما يكون الـ
+
+64
+00:05:56,230 --> 00:06:03,630
+First degree relative ماشي وتكون Early يعني بالذات
+
+65
+00:06:03,630 --> 00:06:09,670
+إذا المرض بيبين على عمره صغير إذا في عندنا أثنين
+
+66
+00:06:09,670 --> 00:06:14,450
+affected first degree relatives هذه high risk one
+
+67
+00:06:14,450 --> 00:06:18,710
+first degree relative with late or unknown disease
+
+68
+00:06:18,710 --> 00:06:24,770
+onsetوشخصين من الجامعة الأولى والأولى وشخصين من
+
+69
+00:06:24,770 --> 00:06:33,550
+الجامعة
+
+70
+00:06:33,550 --> 00:06:37,250
+الأولى والأولى وشخصين من الجامعة الأولى والأولى
+
+71
+00:06:37,250 --> 00:06:38,710
+وشخصين من الجامعة الأولى والأولى وشخصين من الجامعة
+
+72
+00:06:38,710 --> 00:06:40,290
+الأولى والأولى وشخصين من الجامعة الأولى والأولى
+
+73
+00:06:40,290 --> 00:06:40,510
+وشخصين من الجامعة الأولى والأولى وشخصين من الجامعة
+
+74
+00:06:40,510 --> 00:06:42,190
+الأولى والأولى وشخصين من الجامعة الأولى وشخصين من
+
+75
+00:06:42,190 --> 00:06:43,330
+الجامعة الأولى وشخصين من الجامعة الأولى وشخصين من
+
+76
+00:06:43,330 --> 00:06:43,770
+الجامعة الأولى وشخصين من الجامعة الأولى وشخصين من
+
+77
+00:06:43,770 --> 00:06:45,110
+الجامعة الأولى وشخصين من الجامعة الأولى وشخصثلاث
+
+78
+00:06:45,110 --> 00:06:47,710
+أو أكتر مصادر أو مصادر أساسي أو مصادر أساسي أو
+
+79
+00:06:47,710 --> 00:06:49,930
+مصادر أساسي أو مصادر أساسي أو مصادر أساسي أو مصادر
+
+80
+00:06:49,930 --> 00:06:51,010
+أساسي أو مصادر أساسي أو مصادر أساسي أو مصادر أساسي
+
+81
+00:06:51,010 --> 00:06:54,070
+أو مصادر أساسي أو مصادر أساسي أو مصادر أساسي أو
+
+82
+00:06:54,070 --> 00:06:58,950
+مصادر أساسي أو مصادر أساسي أو مصادر أساسي أو مصادر
+
+83
+00:06:58,950 --> 00:06:59,970
+أساسي أو مصادر أساسي أو مصادر أساسي أو مصادر أساسي
+
+84
+00:06:59,970 --> 00:07:05,250
+أو مصادر أساسي أو مصادر أساسي أو مصادر أساسي أو
+
+85
+00:07:05,250 --> 00:07:17,470
+مصادر أساسي أو مصادماشي، يعني بيكون الاحتمالية
+
+86
+00:07:17,470 --> 00:07:23,450
+أكبر وخطورة حدوث مرض وراثي أعلى جداً في حالة وجود
+
+87
+00:07:23,450 --> 00:07:30,000
+أي من هذه الحالاتمن بين، متوسط، moderate risk يكون
+
+88
+00:07:30,000 --> 00:07:33,940
+one first degree relative with late or unknown
+
+89
+00:07:33,940 --> 00:07:36,960
+onset of disease أو two second degree relative
+
+90
+00:07:36,960 --> 00:07:40,020
+from the same lineage with late or unknown disease
+
+91
+00:07:40,020 --> 00:07:47,020
+onset يعني هنا الفكرة كل ما كانت درجة القرابة أقرب
+
+92
+00:07:47,020 --> 00:07:51,530
+first degree مقارنة بsecond أو third degreeوكل ما
+
+93
+00:07:51,530 --> 00:07:57,950
+كان العمر أقل أو أصغر في بداية المرض بيكون
+
+94
+00:07:57,950 --> 00:08:02,490
+احتمالية العامل الوراثي أكبر وهذه حتى احنا شفناها
+
+95
+00:08:02,490 --> 00:08:09,450
+بالنسبة لمقارنة الـ Chromosome مع الـ Single Gene
+
+96
+00:08:09,450 --> 00:08:16,480
+Diseaseاللي هي المجموعة الثالث الـ Polygenic أو
+
+97
+00:08:16,480 --> 00:08:20,900
+Multifactorial Diseases بيصير كل ما كبر الإنسان في
+
+98
+00:08:20,900 --> 00:08:24,420
+الأمر الـ Multifactorial هم اللي أكتر والـ role أو
+
+99
+00:08:24,420 --> 00:08:30,500
+الحجم تبع الـ Genetic Diseases importance بيصير
+
+100
+00:08:30,500 --> 00:08:38,010
+أقل أقل مع تقدم الأمرفهذه مبدأ أو شيء يجب أن
+
+101
+00:08:38,010 --> 00:08:45,750
+يحكمنا ويجب أن نكون منتبهين له لأنه يجب أن يكون في
+
+102
+00:08:45,750 --> 00:08:51,030
+أي مكان نفترض في غزة و لا كذا المفروض أن يكون شخص
+
+103
+00:08:51,030 --> 00:08:57,890
+متخصص بالأمراض الوراثية وهو نوع من التخصصات غريبة
+
+104
+00:08:57,890 --> 00:09:05,590
+قليلاًفي مرات كثيرة طباء أطفال يتخصصوا بمثل هذا
+
+105
+00:09:05,590 --> 00:09:12,070
+التخصص ويدّون تدريب خاص منه على الـ Genetics ومنه
+
+106
+00:09:12,070 --> 00:09:16,890
+على الكلام اللي راح نحكيه كيف الواحد يعمل عملية
+
+107
+00:09:16,890 --> 00:09:20,350
+الـ Counseling كيف الواحد يقود العائلة بالنسبة
+
+108
+00:09:20,350 --> 00:09:29,630
+للتعامل مع حالة مرض ورافي الآن لما نيجي نشوف مين
+
+109
+00:09:31,950 --> 00:09:38,830
+الناس اللي يعني بسعوا أنه يطلبوا الـ Genetic
+
+110
+00:09:38,830 --> 00:09:44,150
+Counseling وبتلاقي يعني الـ Common Indications for
+
+111
+00:09:44,150 --> 00:09:49,470
+Genetic Counseling اللي بحتاج هذا الأمر ماشي هم
+
+112
+00:09:49,470 --> 00:09:57,030
+مجموعة يعني مش كل ال population عادة يعني بتهم هذا
+
+113
+00:09:57,030 --> 00:10:05,110
+الموضوعمرات بتلاقي يعني في حدث
+
+114
+00:10:05,110 --> 00:10:09,990
+معين أو شيء معين صار في عائلة معينة، بالتالي
+
+115
+00:10:09,990 --> 00:10:17,850
+بتخليهم يسعوا أن يحاولوا يدرسوا كام نسبة احتمالية
+
+116
+00:10:17,850 --> 00:10:23,350
+حدوث المرض الوراثي مرة أخرى أو بيطلبوا الـ
+
+117
+00:10:23,350 --> 00:10:27,540
+Counselingفإذا كان عائلة عندهم previous child with
+
+118
+00:10:27,540 --> 00:10:30,140
+multiple congenital anomalies أو intellectual
+
+119
+00:10:30,140 --> 00:10:34,640
+disabilities أو isolated birth defect أو cliff lip
+
+120
+00:10:34,640 --> 00:10:41,260
+و cliff palate يعني شخص عائلة عندها فرد مصاب بمرض
+
+121
+00:10:41,260 --> 00:10:48,140
+ورافي أو احتمال ان يكون ورافيفهنا بيصير فيه اهتمام
+
+122
+00:10:48,140 --> 00:10:52,840
+إنه طب والأطفال اللي بعد ذلك هيصيبهم، مش هيصيبهم،
+
+123
+00:10:52,840 --> 00:10:56,900
+ومش هو الاحتمالية؟ يعني في مرات ناس بيقولك خلاص،
+
+124
+00:10:56,900 --> 00:11:03,030
+بقطع الخلف وما بديشأمر في معاناة طفل مصاب ويعني دا
+
+125
+00:11:03,030 --> 00:11:09,430
+احتمالية صعبة شديدة إنه يكون يتوفى ولا كده فإنما
+
+126
+00:11:09,430 --> 00:11:16,570
+يكون في شخص مصاب في العائلة already بتلاقي يعني
+
+127
+00:11:16,570 --> 00:11:21,490
+بيكون فيه اهتمام إنه يسعوا لحصول على الاستشارة
+
+128
+00:11:21,490 --> 00:11:25,310
+الوراثية إذا في personal history أو family history
+
+129
+00:11:25,310 --> 00:11:29,100
+وhereditary conditionمثل الـ Cystic Fibrosis أو
+
+130
+00:11:29,100 --> 00:11:30,940
+الـ Fragile X Syndrome أو الـ Congenital Heart
+
+131
+00:11:30,940 --> 00:11:34,100
+Disease أو الـ Hereditary Cancer من أنواع الـ
+
+132
+00:11:34,100 --> 00:11:38,440
+cancers اللي لها ارتباط بالعائلة حكينا عن الـ
+
+133
+00:11:38,440 --> 00:11:42,340
+Retinoplastoma أو الـ Family الـ Hereditary
+
+134
+00:11:42,340 --> 00:11:47,500
+Polyposis أو الـ Coli أو فيه أشياء معينة السكري
+
+135
+00:11:47,500 --> 00:11:52,580
+أحياناً فإذا في شخص نفسه أو العائلة عنده مرض معين
+
+136
+00:11:52,920 --> 00:11:58,020
+بتلاقي الأعضاء الأخرين بيهمهم إنه يشوفوا عندهم غير
+
+137
+00:11:58,020 --> 00:12:02,360
+الحطورة
+
+138
+00:12:02,360 --> 00:12:09,720
+نفس الطريقة ولا لأ في حالة إذا كان عائلة عنده
+
+139
+00:12:09,720 --> 00:12:15,240
+chromosomal أو hereditary disorder ويكون المرأة
+
+140
+00:12:15,240 --> 00:12:20,920
+حامل في هذه الوقت بتلاقي بيصير هيكقلق وبيصير
+
+141
+00:12:20,920 --> 00:12:25,800
+anxiety إنه هل هيصير شيء ولا مش هيصير شيء في حالات
+
+142
+00:12:25,800 --> 00:12:29,720
+الـ Pregnancy لشخص
+
+143
+00:12:29,720 --> 00:12:36,460
+أو عائلة عندهم معروف إنه فيه أمراض بروموزومية أو
+
+144
+00:12:36,460 --> 00:12:41,400
+وراثية في حالة الـ Consanguinity يعني هذا الجانب
+
+145
+00:12:41,400 --> 00:12:46,700
+عندنا طبعا يعني في ثقافات أمم أخرىالـ
+
+146
+00:12:46,700 --> 00:12:55,000
+Consanguinity يعني أنا متأكد أو بعرف في مثلًا في
+
+147
+00:12:55,000 --> 00:13:00,540
+ثقافات أخرى مثلًا الروس بنت العم وابن العم هدولة
+
+148
+00:13:00,540 --> 00:13:05,560
+زي الإخوة والأخوات يعني ما بتزوجوا ما بتعرفوا على
+
+149
+00:13:05,560 --> 00:13:11,240
+بعض يعني فعنا الـ Consanguinity في ثقافتنا أكبربس
+
+150
+00:13:11,240 --> 00:13:15,020
+على مستوى بعدي شوية مش first degree أو second
+
+151
+00:13:15,020 --> 00:13:18,720
+degree يعني أو very strong consanguinity موجودة
+
+152
+00:13:18,720 --> 00:13:23,400
+بتلاقي احتمالية تكون موجودة في حالات الـ Teratogen
+
+153
+00:13:23,400 --> 00:13:30,360
+exposure يعني إذا كان إشي معروف إنه بيعمل مشكلة
+
+154
+00:13:30,360 --> 00:13:38,220
+وصار الـ exposure ممكن العائلة تهتم إنها تفهمهل في
+
+155
+00:13:38,220 --> 00:13:45,920
+احتمالية أن يكون شيء Genetic ولا لأ؟ راح ناخد يعني
+
+156
+00:13:45,920 --> 00:13:52,400
+هنا كلمة Teratogen هي مرتبطة بالاشي لما نقول
+
+157
+00:13:52,400 --> 00:13:56,120
+الـCongenital Anomalies الـCongenital يعني خلقي
+
+158
+00:13:56,120 --> 00:14:04,300
+يعني إشي الطفل لما ولد بيبين معاه وكان بيبين معاه
+
+159
+00:14:04,300 --> 00:14:10,150
+فإذا شيء حدث وبالرحم يعنيفمرات مش كل congenital
+
+160
+00:14:10,150 --> 00:14:14,250
+معناته genetic يعني هي لا تساوي هذه congenital
+
+161
+00:14:14,250 --> 00:14:20,990
+يعني في الحمل في خلال فترة الحمل واللي يكون
+
+162
+00:14:20,990 --> 00:14:26,180
+الإنسان جنينويمكن أن يكون كونجينيتال مثلًا «توكسو
+
+163
+00:14:26,180 --> 00:14:32,140
+بلازموسيس» كونجينيتال «روبيلا» مثلًا الحصب
+
+164
+00:14:32,140 --> 00:14:36,300
+الألمانية أو «توكسو بلازموسيس» بيجي من الـ «بيساس»
+
+165
+00:14:36,300 --> 00:14:42,060
+فممكن يعمل التهابات أو مرض في الجنين من خلال إصابة
+
+166
+00:14:42,060 --> 00:14:46,320
+الأم بهذا الشيء فأحيانًا الـ «تيراتوجين» يعني هو
+
+167
+00:14:46,320 --> 00:14:50,610
+بالأخير هيكون شيء خلقييعني سيولد الإنسان فيه، لكن
+
+168
+00:14:50,610 --> 00:14:55,650
+ليس بالضرورة جينيتيكي بس التعامل بينهم قريب كذلك
+
+169
+00:14:55,650 --> 00:14:59,950
+العائلات اللي عندهم repeated pregnancy loss أو
+
+170
+00:14:59,950 --> 00:15:03,470
+infertility هذه برضه من الأشياء اللي بتصير ندور
+
+171
+00:15:03,470 --> 00:15:08,230
+على chromosomal anomalies أو unemployed دي
+
+172
+00:15:08,230 --> 00:15:12,510
+والأشياء اللي زي هيكة فلما نكون في عائلة أو couple
+
+173
+00:15:13,440 --> 00:15:20,060
+زوجين في عندهم مشكلة في عقم وعدم خلفة ممكن أو
+
+174
+00:15:20,060 --> 00:15:23,980
+repeat pregnancy loss طبعاً ممكن يكون أمراض أخرى
+
+175
+00:15:23,980 --> 00:15:30,620
+بس هذه برضه بتكون من الأشياء اللي بيصير عندنا اه
+
+176
+00:15:30,620 --> 00:15:37,000
+يعني اهتمام من الحصول على الاستشارة الوراثية newly
+
+177
+00:15:37,000 --> 00:15:41,030
+diagnosed anomaly or genetic conditionهذه برضه
+
+178
+00:15:41,030 --> 00:15:47,410
+ناحية مهمة عادةً عادةً حتى في عائلة الكل بيخبر بعض
+
+179
+00:15:47,410 --> 00:15:55,430
+فإذا كان إنسان يعني اتشخص بمرض وراثي معين تلقائيًا
+
+180
+00:15:55,430 --> 00:16:00,390
+هتلاقي أفراد العائلة الأخرى إخوانه، خواته، ولاد
+
+181
+00:16:00,390 --> 00:16:06,890
+عمه، مش عارف مين، هيصير كلهم عندهمقلق أو anxiety
+
+182
+00:16:06,890 --> 00:16:12,130
+ويقولوا طب وأنا شو احتماليتي وشو عندي هل أنا كذا
+
+183
+00:16:12,130 --> 00:16:18,330
+فلما يكون تشخيص جديد ومرض جديد هيكون فيه اهتمام في
+
+184
+00:16:18,330 --> 00:16:24,270
+العائلة لطلب استشارة ورافية before undertaking
+
+185
+00:16:24,270 --> 00:16:27,190
+genetic testing and after receiving results
+
+186
+00:16:27,190 --> 00:16:30,870
+particularly in testing for susceptibility of late
+
+187
+00:16:30,870 --> 00:16:40,720
+onset disorders ماشيهذه ناحية مهمة، وهي شغل نادرة،
+
+188
+00:16:40,720 --> 00:16:47,960
+يعني حكينا مثلًا، يعني في على الأقل ثلاث احتمالات،
+
+189
+00:16:47,960 --> 00:16:51,220
+على الأقل أمراض هيكي بتكون عندها الحالة بهذا
+
+190
+00:16:51,220 --> 00:16:56,370
+الطريقةاللي هي مثلًا زي ما حكينا إشي أوتوزامل
+
+191
+00:16:56,370 --> 00:17:00,610
+dominant زي «هانتنغتونز كوريا» أو «Huntington's
+
+192
+00:17:00,610 --> 00:17:05,930
+Disease» بيعمل Paralysis وبيعمل Premature Death بس
+
+193
+00:17:05,930 --> 00:17:10,330
+المرض ما بيبدأ إلا على عمر الأربعين، تلاتين، ستين
+
+194
+00:17:10,330 --> 00:17:16,770
+فتلاقي الإنسان اتزوج وخلف وبعدين فجأة يصاب بمرض
+
+195
+00:17:16,770 --> 00:17:24,870
+بيدي للوفاةفولاده وبناته بيصير عندهم يعني قلق
+
+196
+00:17:24,870 --> 00:17:31,470
+وبدهم يعرفوا شو وضعي أنا فالفكرة أنه أنا ما بيصير
+
+197
+00:17:31,470 --> 00:17:37,590
+أنا أجي أعمل الـ Test و بعدين هكذا و Technician أو
+
+198
+00:17:37,590 --> 00:17:41,130
+إنسان مش خبير ييجي يعطي الإنسان هذا التشخيص
+
+199
+00:17:41,130 --> 00:17:49,160
+وانتهينا، لأ، هذا بدت تقعد الـ Counselorالمستشار
+
+200
+00:17:49,160 --> 00:17:53,840
+يكون فهماً ويقعد مع العيلة قبل ما يعملوا الـ Test
+
+201
+00:17:53,840 --> 00:17:58,000
+يفهمهم ما هو الـ Disease اللي احنا بندور عليه كيف
+
+202
+00:17:58,000 --> 00:18:04,040
+الـ Test راح نعمله؟ وشو الممكن؟ وشو نتيجة تبعت الـ
+
+203
+00:18:04,040 --> 00:18:09,660
+Test؟ كيف نقرأها؟ وبرضه برضه بيظل فيه مشاكل وكذلك
+
+204
+00:18:09,660 --> 00:18:16,910
+مثلا Cancer زي مثلا حكينا اللي هي مثلاحكينا
+
+205
+00:18:16,910 --> 00:18:23,390
+الممثلة العالمية جدولنا عن القردن طلع عندها Braca
+
+206
+00:18:23,390 --> 00:18:28,550
+gene وصوت bilateral mastectomy شارت التديين عندها
+
+207
+00:18:28,550 --> 00:18:33,270
+وكذا عشان عندها strong family history و bilateral
+
+208
+00:18:33,270 --> 00:18:38,810
+cancer في ال breast وبكون عندها hereditary form of
+
+209
+00:18:38,810 --> 00:18:43,470
+cancer أو neurological diseaseهذه ملاحظة مرات
+
+210
+00:18:43,470 --> 00:18:50,370
+كثيرة مثلًا من الأشياء المفهومة مثلًا
+
+211
+00:18:50,370 --> 00:18:56,590
+تشخيص الـ HIV الـ HIV زمان كان زي الحكم بالموت
+
+212
+00:18:56,590 --> 00:19:03,210
+والنبذ والناس تبتعد عن المريض وكذا وكذافكون إن
+
+213
+00:19:03,210 --> 00:19:08,970
+واحد يتعمل HIV، إحنا نعمل HIV لكل واحد مثلا بتبرع
+
+214
+00:19:08,970 --> 00:19:12,750
+بالدم الأصل، مع الـ Hepatitis، مع غيرها، مع غيرها،
+
+215
+00:19:12,750 --> 00:19:16,630
+مع غيرها، مع غيرها، ما بيصير لو طلعت النتيجة
+
+216
+00:19:16,630 --> 00:19:20,630
+إيجابية إنه هيك اتزدها للمريض ذات أو للإنسان هذا
+
+217
+00:19:20,630 --> 00:19:24,010
+ذات طبعا ممكن لو كانت إيجابية إنها تكون False
+
+218
+00:19:24,010 --> 00:19:28,590
+Positive يعني هي مش حقيقية بس والله صارت إنه واحد
+
+219
+00:19:28,590 --> 00:19:33,230
+يسمع النتيجة إنه إيجابييروح ينتحر وخلاص يقولك شوها
+
+220
+00:19:33,230 --> 00:19:38,170
+العيش وشوها الحياة وأنا يعني خلاص I'm going to die
+
+221
+00:19:38,170 --> 00:19:42,390
+مع أن الكلام مش صحيح أبداً فهذه أشياء sensitive
+
+222
+00:19:42,390 --> 00:19:47,850
+والواحد يعمل counseling قبل وبعد ما يعمل ال test
+
+223
+00:19:47,850 --> 00:19:53,810
+لازم ولازم الواحد يعني فهما يستوعب العائلة ويستوعب
+
+224
+00:19:53,810 --> 00:19:57,290
+الإنسان اللي أمامه المريض أو العائلى أو الأبوين
+
+225
+00:19:57,720 --> 00:20:03,980
+ويفهمهم كلام مفهوم ويتفق على آليات معينة فالنقطة
+
+226
+00:20:03,980 --> 00:20:08,060
+الأخيرة حكينا اللي هي as a follow-up for positive
+
+227
+00:20:08,060 --> 00:20:16,860
+result of a newborn test ماشي، يعني هي الفكرة هنا
+
+228
+00:20:16,860 --> 00:20:22,600
+حاطين أنواع من الأشياء ال test اللي بتنعمل، النقاط
+
+229
+00:20:22,600 --> 00:20:34,410
+هناعندنا مثلًا في القردن كل الأطفال عند أول تطعيم
+
+230
+00:20:34,410 --> 00:20:39,710
+بعد أسبوع أو خلال الفترة الأولى من نقطة من القدم
+
+231
+00:20:39,710 --> 00:20:50,190
+على ورقة نشاف بنشفوا نقطة الدم وبعدها تُبعث للفحص
+
+232
+00:20:50,980 --> 00:20:55,920
+الـ Phenylketonuria والـ Thyroid وحتى الـ HIV أظن
+
+233
+00:20:55,920 --> 00:21:02,060
+بيعملوه روتين للكل ماشي، فإيه ده؟ طبعاً كل هذه
+
+234
+00:21:02,060 --> 00:21:07,500
+الفحوصات مش 100% الـ Sensitivity و Specificity
+
+235
+00:21:07,500 --> 00:21:11,620
+تبعتها يعني لو Positive ممكن تكون False Positive
+
+236
+00:21:11,620 --> 00:21:14,820
+لو Negative ممكن كمان تكون False Negative يعني حتى
+
+237
+00:21:14,820 --> 00:21:20,160
+لو فحص ممتاز 99% بيجيبها صح مافي إشي 100% في
+
+238
+00:21:20,160 --> 00:21:27,540
+الدنيا يعنيففي أمراض معينة لو أجت لسبب طلع نتيجة
+
+239
+00:21:27,540 --> 00:21:34,140
+إيجابي أو plus minus يعني على الحفة فكيف بدنا نفهم
+
+240
+00:21:34,140 --> 00:21:39,940
+العائلة هذا الموضوع هي بدها أنه يصير genetic
+
+241
+00:21:39,940 --> 00:21:43,960
+counseling الـ
+
+242
+00:21:44,840 --> 00:21:48,580
+أنا بحكي، أنا بتكلم، إذا حد عنده سؤال، يسأل إذا
+
+243
+00:21:48,580 --> 00:21:54,880
+فيه إيش مش واضح، شو اسمه، احكولي وخلّينا بنوقف
+
+244
+00:21:54,880 --> 00:21:59,680
+وبنعيد، يعني، ماشي الحال؟ فدولة الـ Indications
+
+245
+00:21:59,680 --> 00:22:04,140
+for Genetic Counseling دولة العادة الحوادث أو
+
+246
+00:22:04,140 --> 00:22:10,880
+القصص أو الأشياء اللي تدفع بعض العائلات ليطلبوا
+
+247
+00:22:10,880 --> 00:22:12,520
+الـ Genetic Counseling
+
+248
+00:22:15,080 --> 00:22:19,900
+لما يأتي الإنسان اللي هو الـ Counselor، ما هو
+
+249
+00:22:19,900 --> 00:22:24,920
+المفروض أن يفعله؟ النقطة الأولى، يجب أن يقوم
+
+250
+00:22:24,920 --> 00:22:27,940
+بـCollection of Information اللي هي الـ Family
+
+251
+00:22:27,940 --> 00:22:31,880
+History، الـ Medical History والـ Previous Tests
+
+252
+00:22:31,880 --> 00:22:35,440
+وAdditional Assessments يعني كل هذه الجوانب، يجب
+
+253
+00:22:35,440 --> 00:22:41,920
+أن يجمعها ويرتبها مع بعض الـ Family History يمكن
+
+254
+00:22:41,920 --> 00:22:47,320
+من أهم شيءأيه قضية اللي هي الـ Pedigree؟ ماشي،
+
+255
+00:22:47,320 --> 00:22:55,160
+فمين في العائلة مصاب، على أي عمر بدأت، شو علاقاتهم
+
+256
+00:22:55,160 --> 00:22:59,500
+ببعض، متأكد الواحد من المعلومة، مش متأكد، يجمع
+
+257
+00:22:59,500 --> 00:23:02,220
+المعلومات كلها، فأول شيه Collection of
+
+258
+00:23:02,220 --> 00:23:06,640
+Information، هذه نقطة أساسية، بعدين لازم يفحص
+
+259
+00:23:06,640 --> 00:23:12,610
+المريض، ويشوف كل نتاجه، Physical Examination،عنده
+
+260
+00:23:12,610 --> 00:23:18,550
+ما عندهوش مثلًا يعني والله أنا شُفت مثلًا إنسان
+
+261
+00:23:18,550 --> 00:23:25,130
+طويل وعنده high arch بلد وعنده أنا فكرت أنه عنده
+
+262
+00:23:25,130 --> 00:23:29,250
+إيش بنسميه «marfan syndrome» ولا كذا وإيكي هذا
+
+263
+00:23:29,250 --> 00:23:33,270
+مرتبط مثلًا بـcongenital heart disease فيمكن
+
+264
+00:23:33,270 --> 00:23:37,450
+المريض عنده «مرمر» وعنده مشكلة في القلب ومريض فعلا
+
+265
+00:23:37,450 --> 00:23:41,280
+وعنده «congenital»بس ماكانش حدا لأنه ماشتكاش،
+
+266
+00:23:41,280 --> 00:23:45,600
+ماحدش فحصه فمش عارفين عن وجود أو عدم وجود جانب
+
+267
+00:23:45,600 --> 00:23:50,980
+معين بعدين الـ Physical Examination الـ Laboratory
+
+268
+00:23:50,980 --> 00:23:54,180
+of Radiological Testing وValidation or
+
+269
+00:23:54,180 --> 00:23:59,420
+Establishment of Diagnosis if possible، ماشي؟ يعني
+
+270
+00:23:59,420 --> 00:24:04,340
+بيجمع الواحد كمان كل النتائج بما فيها الأشعات
+
+271
+00:24:04,340 --> 00:24:11,060
+السابقة والنتائج تبعتهاوالـ Validation أو الـ
+
+272
+00:24:11,060 --> 00:24:14,280
+Establishment بالذات فيه فرصات أدق على هذا الموضوع
+
+273
+00:24:14,280 --> 00:24:23,820
+يعني إنسان عنده مثلًا والله ضمور في العضلات وخلل
+
+274
+00:24:23,820 --> 00:24:31,060
+في العضلات لو كان الشغل هذه من الصغر ومن الطفولة
+
+275
+00:24:31,600 --> 00:24:36,040
+بتكون مرض معين، بس لو نفس المشكلة أو إشي شبيه فيها
+
+276
+00:24:36,040 --> 00:24:40,320
+على عمر أكبر، لأ، بتصير بكر disease بدل Duchenne
+
+277
+00:24:40,320 --> 00:24:46,200
+muscular dystrophy فبتصير يعني التشخيص على أي عمر
+
+278
+00:24:46,200 --> 00:24:50,540
+كانت، فحتى نتأكد أن المشكلة ما بدت بعمر أسبق،
+
+279
+00:24:50,540 --> 00:24:54,720
+فنشوف النتاج القديمة ونجمعها الـ Counseling
+
+280
+00:24:58,040 --> 00:25:02,040
+تتكلم الواحد على الـ Nature وConsequences of the
+
+281
+00:25:02,040 --> 00:25:10,160
+Disorder يعني، ماذا يريد أن يشرح للذي أمامه؟ ما هو
+
+282
+00:25:10,160 --> 00:25:16,680
+المرض؟ وما هو طبيعته؟ وما هو نتاجه؟ بما فيها أرقام
+
+283
+00:25:16,680 --> 00:25:22,120
+واحتمالات وكذلك الـ Recurrence Risk Availability
+
+284
+00:25:22,120 --> 00:25:28,540
+of Further or Future Testingيعني مثلًا الـ Down
+
+285
+00:25:28,540 --> 00:25:32,400
+Syndrome الـ Down Syndrome ماشي هو هذا الإنسان
+
+286
+00:25:32,400 --> 00:25:36,520
+عنده Down Syndrome بس في نفس الوقت ممكن الـ Down
+
+287
+00:25:36,520 --> 00:25:42,380
+Syndrome يكون مزايق يعني الـ Trisomy 21 مش في كل
+
+288
+00:25:42,380 --> 00:25:46,280
+الـ Cells في نص الـ Cells، في تلت أرباع الـ Cells،
+
+289
+00:25:46,280 --> 00:25:50,420
+في عشرين بالمئة بالـ Cells فبتصير درجات من هذه
+
+290
+00:25:50,420 --> 00:25:57,050
+الحالة، بالتالي بكونيعني توقعنا بالنسبة لشو نعمل
+
+291
+00:25:57,050 --> 00:26:03,230
+أو شو درجتنا، شو يعني توقعنا عن المستقبل راح يكون
+
+292
+00:26:03,230 --> 00:26:08,470
+قراءتنا للمستقبل بتكون تختلف، بعدين الـ decision
+
+293
+00:26:08,470 --> 00:26:13,070
+making شو القرارات اللي ممكن تتنفق عليها referral
+
+294
+00:26:13,070 --> 00:26:16,470
+to other specialists أو health agencies أو support
+
+295
+00:26:16,470 --> 00:26:23,660
+groups يعني مثلا أنا واللهالقيت حالي عنده final
+
+296
+00:26:23,660 --> 00:26:30,620
+cataneuria إذا يمكن الأهل والناس أولها بيصدموا «شو
+
+297
+00:26:30,620 --> 00:26:35,240
+هالشغل؟» بخاف الواحد وكذا بعدين بحكيله «والله هاي
+
+298
+00:26:35,240 --> 00:26:38,960
+لا، والله الشغل شائعة» «في عنا جمعية بتقوم
+
+299
+00:26:38,960 --> 00:26:44,340
+بالرعاية هذه الحالات» إذا اتعامل الواحد مظبوط مع
+
+300
+00:26:44,340 --> 00:26:49,380
+المرض من الصغر وابتشف مبكر والعلاج والأكل مظبوط
+
+301
+00:26:49,670 --> 00:26:53,110
+الطفل اللي بيعيش أو الإنسان هذا بيطلع طبيعي ومافيش
+
+302
+00:26:53,110 --> 00:26:57,590
+معاه مشكلة فبوديه على الـ Support Groups فيه
+
+303
+00:26:57,590 --> 00:27:03,090
+عيادات معينة إنهم فيه جمعيات متخصصة بتعتني فيهم
+
+304
+00:27:03,090 --> 00:27:08,970
+فيه كذا فيه كذا فكله بتصير الواحد يعطيهم يعني
+
+305
+00:27:08,970 --> 00:27:13,600
+يقودهم في أنه يتعاملوا مع المرض هذاcontinuing
+
+306
+00:27:13,600 --> 00:27:16,440
+clinical assessment especially if no diagnosis
+
+307
+00:27:16,440 --> 00:27:20,480
+وطبعاً الـ Psychosocial support هذه نواحي مهمة
+
+308
+00:27:20,480 --> 00:27:24,000
+كثير إن الواحد يظل يتابع إذا واحد ما يعرفش إيش
+
+309
+00:27:24,000 --> 00:27:29,440
+يقول، مايعرفش، مش متأكد ما يفتي بثقة، يحكي بثقة
+
+310
+00:27:29,440 --> 00:27:39,720
+للي أمامه، هو يعني مش متأكد، بس في المقابل يعني من
+
+311
+00:27:39,720 --> 00:27:44,050
+أهم الجوانب، يعني بقدر حواليثلاثين بالمية من تأثير
+
+312
+00:27:44,050 --> 00:27:50,630
+الطب هو تأثير نفسي يعني اللي بيسموه الـ placebo
+
+313
+00:27:50,630 --> 00:27:55,630
+effect يعني كثير من مثلا بيكون بطن الواحد بوجعه
+
+314
+00:27:55,630 --> 00:28:00,130
+وفي لحظة ما بيبدأ يدخل على المستشفى يكون بيصرخ و
+
+315
+00:28:00,130 --> 00:28:05,190
+بعيط و كده بس لسه بده يدخل على باب الطوارئ بيدلاق
+
+316
+00:28:05,190 --> 00:28:11,170
+الألم خارج وهذه ظاهرة لكل بعرفها وهذه يعنيدور من
+
+317
+00:28:11,170 --> 00:28:18,470
+أدوار الـ Counselor إنه يؤديها الـ
+
+318
+00:28:18,470 --> 00:28:24,810
+«دكتور»؟ نعم في سؤال الماضي بتسأل إنه مش كل
+
+319
+00:28:24,810 --> 00:28:29,190
+الـGenetic Disease بيكونوا Congenital؟ لأ، ما هو،
+
+320
+00:28:29,190 --> 00:28:33,630
+شوفي أنا اتكلمت عن الموضوع هذا يعني زي
+
+321
+00:28:33,630 --> 00:28:38,820
+Huntington's Chorea أو Huntington's Diseaseهذا مرض
+
+322
+00:28:38,820 --> 00:28:46,060
+في الأعصاب، الإنسان بولد طبيعي، بعيش طبيعي، بخلف،
+
+323
+00:28:46,060 --> 00:28:51,740
+بكون عائلة على سن الأربعين، خمسين، ستين، بظهر عنده
+
+324
+00:28:51,740 --> 00:28:59,180
+المرض وهو Autosomal Dominant فكلمة Congenital تعني
+
+325
+00:28:59,180 --> 00:29:04,700
+«ظهرت عند الولادة» يعني لما نولد الإنسان، هاي
+
+326
+00:29:04,700 --> 00:29:09,710
+الشغر مبين عندهفكلمة «congenital» يعني حكينا
+
+327
+00:29:09,710 --> 00:29:15,430
+«congenital toxoplasmosis» «congenital rubella»
+
+328
+00:29:15,430 --> 00:29:20,010
+هدولة يعني هن «congenital» بس هدولة «infectious
+
+329
+00:29:20,010 --> 00:29:24,050
+disease» مش «genetic» فكلمة «genetic» و
+
+330
+00:29:24,050 --> 00:29:28,390
+«congenital» لا تعني نفس الكلمة ماشي، يعني في
+
+331
+00:29:28,390 --> 00:29:31,630
+أمراض «genetic» مش «congenital» لإن نقدرش نعتبرها
+
+332
+00:29:31,630 --> 00:29:35,530
+«congenital» بس أحياناً يعني «hereditary» و
+
+333
+00:29:35,530 --> 00:29:41,740
+«congenital»بتُعطى كأنه مصطلحات قريبان من بعض
+
+334
+00:29:41,740 --> 00:29:46,320
+وكأنها نفس المعنى يعني بقصد الواحد إشي ورافي يعني،
+
+335
+00:29:46,320 --> 00:29:52,100
+ماشي؟ فالورافي مش ضروري تظهر عند الولادة، واضح؟
+
+336
+00:29:52,100 --> 00:29:56,020
+فلما الواحد يستخدم مصطلح، بده، بالذات إذا فيه
+
+337
+00:29:56,020 --> 00:30:02,080
+فروقات بينهم، بده ينتبهلها، ماشي؟ يعني Congenital
+
+338
+00:30:02,080 --> 00:30:08,540
+Heart Disease، ماشي؟بكون خلل معين هو خلقي وحتى لو
+
+339
+00:30:08,540 --> 00:30:12,540
+ما اكتشفتوش بالأول بس لو كنت أنا فحست عليه عند
+
+340
+00:30:12,540 --> 00:30:16,180
+الولادي يعني مثلا في congenital heart disease الـ
+
+341
+00:30:16,180 --> 00:30:23,080
+«Communist» بيسموه «Bicusp aortic valve» الصمام
+
+342
+00:30:23,080 --> 00:30:27,320
+الأبهر الـ«اوارتك» المفروض له ثلاث شفائف، له ثلاث
+
+343
+00:30:27,320 --> 00:30:34,300
+قطع بالنسبة للناس، بتكون من قطعتين فقطهذا ممكن إذا
+
+344
+00:30:34,300 --> 00:30:39,940
+ما حدش فحص عليه بدقة أو دور عليه يبين بعدين على سن
+
+345
+00:30:39,940 --> 00:30:44,660
+العشرين، تلاتين، أربعين بيبين أوورتكستناصس بيبين
+
+346
+00:30:44,660 --> 00:30:49,580
+عند الإنسان بيخلي عنده يظهر مشكلة تتطور وبتبين
+
+347
+00:30:49,580 --> 00:30:54,790
+بعدين فهي تلغى هذه النوع من المشكلةصحيح إننا
+
+348
+00:30:54,790 --> 00:31:00,670
+اكتشفناها متأخر بس هي خلقية يعني congenital يعني
+
+349
+00:31:00,670 --> 00:31:09,330
+من ولادته بدأت فيه، ماشي؟ بس مش كل congenital
+
+350
+00:31:09,330 --> 00:31:15,150
+بالضرورة genetic، خلّينا نكون واضحين، ماشي؟ فاحنا
+
+351
+00:31:15,150 --> 00:31:20,530
+أحيانًا كثيرة نستخدم المصطلحين بشكل متبادل بس هم
+
+352
+00:31:20,530 --> 00:31:22,770
+لأ مش نفس المعنى
+
+353
+00:31:27,150 --> 00:31:34,130
+واضح؟ ‏- لا تمام يا دكتور ‏- أه الـ Genetic
+
+354
+00:31:34,130 --> 00:31:40,070
+Counseling ‏and Risk Assessment ‏يعني الـ أحنا
+
+355
+00:31:40,070 --> 00:31:44,970
+المطلوب هنا أول شيء أن نفهم العائلة الـ Medical
+
+356
+00:31:44,970 --> 00:31:52,790
+Facts ‏يعني ضروري الـإذا العائل يمكن أنه صعب أن
+
+357
+00:31:52,790 --> 00:31:56,750
+يدرس الواحد طب ويدرس قليل من الـ Genetics وكذا
+
+358
+00:31:56,750 --> 00:32:01,610
+فالدور
+
+359
+00:32:01,610 --> 00:32:07,810
+الأول المطلوب أنه نتأكد إنهم فاهمين النواحي
+
+360
+00:32:07,810 --> 00:32:17,310
+العلمية الطبية السليمة الأساسية عن التشخيص وندرسهم
+
+361
+00:32:17,310 --> 00:32:23,810
+علىكيف تنتقل؟ وليش تنتقل؟ وما هي الخطورة أو
+
+362
+00:32:23,810 --> 00:32:28,930
+احتمالية عودة المشكلة معاهم أو في أعضاء العائل
+
+363
+00:32:28,930 --> 00:32:35,610
+الآخرين؟ أعطاهم خيارات
+
+364
+00:32:35,610 --> 00:32:39,590
+ما يعملونه للمستقبل وكيف يتعاملوا مع الحالة يعني
+
+365
+00:32:39,590 --> 00:32:44,970
+أنا كثير مع الدكتورة، الله يرضى عنها الدكتورة
+
+366
+00:32:45,560 --> 00:32:50,640
+الوراثة في الأطفال، التناسق في الحيط نقعد مثلًا مع
+
+367
+00:32:50,640 --> 00:32:58,940
+عيلة عندهم مثلًا فيناكوتينيوريا ونسير يعني يكون
+
+368
+00:32:58,940 --> 00:33:02,620
+مثلًا الأب والأم يتلوموا أنت المرض منك، أنت المرض
+
+369
+00:33:02,620 --> 00:33:08,220
+منك، لأ المرض أنتم اتنين مشتركين فيه مثلًا يعني
+
+370
+00:33:08,220 --> 00:33:12,560
+هذه ناحية بدّوا الواحد ينتبهي لها فمثلًا هذه
+
+371
+00:33:12,560 --> 00:33:17,440
+العائلات بعضهمكنا ننصحهم مثلًا، خلاص، ما تخلفوش
+
+372
+00:33:17,440 --> 00:33:24,440
+طبعًا في دول تانية ممكن يكون مثلًا الإجهاض خيار بس
+
+373
+00:33:24,440 --> 00:33:28,060
+إحنا مثلًا عندنا نقول لهم لأ ما تخلفوش كمان ولاد
+
+374
+00:33:28,060 --> 00:33:33,200
+عشان لأنه لسه فيه نسبة ونعتبرها نسبة عالية لأنه
+
+375
+00:33:33,200 --> 00:33:41,560
+معاناة شديدة أنه يكون هناك مرض يعني بالنسبة لما
+
+376
+00:33:41,560 --> 00:33:46,560
+نتعامل بهذه النقاطمعرفة الـ Values، Beliefs،
+
+377
+00:33:46,560 --> 00:33:52,520
+Goals، Relationships نتيجة الـ Presence of
+
+378
+00:33:52,520 --> 00:33:57,700
+Hereditary Diseases يعني بد الواحد يراعي في هذا
+
+379
+00:33:57,700 --> 00:34:09,080
+الموضوع بدنا نسميه ثقافة، الدين، أخلاقيات، مفاهيم
+
+380
+00:34:09,080 --> 00:34:16,190
+الإنسان اللي أمامه يعني إحناأقول دايماً للدكاترة
+
+381
+00:34:16,190 --> 00:34:21,890
+وللطباء إحنا لما واحد يصير طبيب بقسم يعني بحلف
+
+382
+00:34:21,890 --> 00:34:29,210
+بالله أنه راح نعالج القريب والعدو الصالح والخاطر
+
+383
+00:34:29,210 --> 00:34:37,550
+القريب والبعيد يعني أنا كإنسان طبيب لمن يلجألي شخص
+
+384
+00:34:37,550 --> 00:34:43,290
+لأنه طبيبفي أخلاقيات أنا مسؤول عنها ومنها إنه
+
+385
+00:34:43,290 --> 00:34:47,950
+أحترم هذا الإنسان أحترم خصوصيته أحترم سرية
+
+386
+00:34:47,950 --> 00:34:54,510
+معلوماته أحترم مفاهيمه فهذا الاحترام يكون بنتج عنه
+
+387
+00:34:54,510 --> 00:35:01,290
+إن أنا لازم أحترم طبعاً يعني النواحي الفردية هذه
+
+388
+00:35:01,290 --> 00:35:06,510
+التابعته بغض النظر عن إن أنا قابلها ولا مش قابلها
+
+389
+00:35:06,510 --> 00:35:11,120
+عجباني مش عاجبانيبسوي على حالي و لا لأ خلاص لازم
+
+390
+00:35:11,120 --> 00:35:16,400
+احترم مين ما يكون أمامي ماشي و في نفس الوقت يعني
+
+391
+00:35:16,400 --> 00:35:23,500
+أنا بظن جانب مهمة احنا لازم يعني في الجوانب هذه
+
+392
+00:35:23,500 --> 00:35:30,860
+الجوانب المجتمعية بما فيها من قوانين من أعراف تحكم
+
+393
+00:35:30,860 --> 00:35:36,780
+التعامل مع هذه الجانبوبالتالي، يعني أنا لازم أسهل
+
+394
+00:35:36,780 --> 00:35:41,660
+و أشرح لهم يعني يمكن عائلة بتفضل إشي معين بس
+
+395
+00:35:41,660 --> 00:35:46,840
+القانون يمنعه مثلا، بدي أوفق بينها و بدي أشرح
+
+396
+00:35:46,840 --> 00:35:52,180
+للجميع و نشرح شو نعمله و كيف نعمله و بعدين،
+
+397
+00:35:52,180 --> 00:35:58,200
+الاختيار ال course of action ماشي، نساعدهم كيف، شو
+
+398
+00:35:58,200 --> 00:36:04,870
+اللي يعملوا، راح نيجي بعد شويةعلى قضية الـ…. يعني
+
+399
+00:36:04,870 --> 00:36:11,090
+الـ…. إذا كان في طريق التشخيص أمراض وراثية بشكل
+
+400
+00:36:11,090 --> 00:36:16,370
+تداخلي، بشكل invasive لنأخذ عينة ولا نعمل شغل ولا
+
+401
+00:36:16,370 --> 00:36:23,210
+كذا، وبعدين إذا كان يعني بما أن الواحد هنا اللي
+
+402
+00:36:23,210 --> 00:36:27,610
+بيعمل counseling هو أخبر واحد في بالنسبة لتعامل مع
+
+403
+00:36:27,610 --> 00:36:33,540
+المرض، تخفيف أثاره،تعامل مع تعليف الإنسان هذا أو
+
+404
+00:36:33,540 --> 00:36:39,120
+العائلة بالمشاكل أو ما هي الخيارات اللي أمامهم،
+
+405
+00:36:39,120 --> 00:36:44,780
+فدول كلها جوانب مهمة من
+
+406
+00:36:44,780 --> 00:36:52,940
+النواحي المهمة، وهنا حاطين مثال عليها، قضية أن الـ
+
+407
+00:36:52,940 --> 00:36:59,540
+Counselor لازم يعطي العائلةالأصل، يعني وذلك بالذات
+
+408
+00:36:59,540 --> 00:37:04,720
+عائلة فهمانة ويمكن هذا في الدول الغربية ثقافتهم في
+
+409
+00:37:04,720 --> 00:37:09,660
+هذا الجوانب أحسن مننا بالنسبة لقضية أنه بدك رقم
+
+410
+00:37:09,660 --> 00:37:11,620
+وعلى أساس أنك أنت إنسان علمي
+
+411
+00:37:14,200 --> 00:37:22,100
+بالنسبة للـ «Risk Assessment» ماشي، اللي هي شو
+
+412
+00:37:22,100 --> 00:37:25,740
+إحتمالية إنه هذا الإنسان عنده كده، شو إحتمالية
+
+413
+00:37:25,740 --> 00:37:30,840
+كده، فهي قضية الإحصاء والاحتماليات، هنا جانب يجب
+
+414
+00:37:30,840 --> 00:37:36,700
+أن يكون شاطر فيه، فلما نرسم الـB degree، لازم
+
+415
+00:37:36,700 --> 00:37:44,310
+بالأخير كمان نحصل الشيء اسمه،منها معلومات رقمية
+
+416
+00:37:44,310 --> 00:37:51,550
+ممكن نعطيها للعائلة حتى نساعدهم فهنا مثلًا هذا مرض
+
+417
+00:37:51,550 --> 00:37:56,330
+Autism Recessive مثلًا Penile Continuity الآن
+
+418
+00:37:56,330 --> 00:38:05,290
+الإنسان هذا اللي هو الأزرق المصاب عنده Two copies
+
+419
+00:38:05,290 --> 00:38:08,830
+لأنه Autism Recessive فعنده Two copies of the
+
+420
+00:38:08,830 --> 00:38:15,920
+affected gene ماشيالآن الأب والأم، هذه الأم وهذا
+
+421
+00:38:15,920 --> 00:38:24,540
+الأب لازم يكون Carrier فاحتمالية إنه عنده Copy من
+
+422
+00:38:24,540 --> 00:38:34,780
+الـ…. ما هو اسمه؟عنده يكون copy من الـ «أفكتت جين»
+
+423
+00:38:34,780 --> 00:38:39,000
+is one percent يعني one hundred percent، ماشي؟
+
+424
+00:38:39,000 --> 00:38:44,180
+ماعندهوش أكيد two copies لأنه مش مصاب، لو كان الأب
+
+425
+00:38:44,180 --> 00:38:49,760
+أو الأم مصابين زي الإبن، ماشي؟ يمكن ماكانوش خلفوا
+
+426
+00:38:49,760 --> 00:38:54,740
+أو ماكانوش اتجوز و لا كده، بس هي تعني أنه احتمالية
+
+427
+00:38:54,740 --> 00:38:58,390
+أن يكون الإنسان عندهالـ One copy of the affected
+
+428
+00:38:58,390 --> 00:39:08,010
+gene هنا 1% العائلة البقيتها يعني هنا الاحتمالية
+
+429
+00:39:08,010 --> 00:39:14,870
+100% وبالتالي بناخد أنه نص بنص كان للجدود بالنسبة
+
+430
+00:39:14,870 --> 00:39:22,700
+لهذا الإنسانوالأمر بينطبق على الطرفين، ماشي؟ لو
+
+431
+00:39:22,700 --> 00:39:31,420
+هنا مثلًا بالنسبة للإنسان هذا النسبة
+
+432
+00:39:31,420 --> 00:39:39,800
+إنه يكون مثلًا هنا بنت عمه، ماشي؟ هي هنا، لأ، هي
+
+433
+00:39:39,800 --> 00:39:48,540
+تطلع هنا الزلمي هذا اتزوج أول مرةجاب يعني اتزوج من
+
+434
+00:39:48,540 --> 00:39:54,980
+امرأة ثانية معينة وجاب طفل مصاب اتزوج مرة ثانية
+
+435
+00:39:54,980 --> 00:40:01,060
+بزوجة ثانية كان عندها، هاي لأ، هاي أخته أنا آسف،
+
+436
+00:40:01,060 --> 00:40:10,360
+هاي أخته فأخته بما أنه الاحتمالي،
+
+437
+00:40:10,360 --> 00:40:13,200
+يعني هذا إنسان حامل لـone copy of the gene
+
+438
+00:40:13,200 --> 00:40:20,460
+definite أنا متأكدماشي، أخذوا نص من الاحتمال من
+
+439
+00:40:20,460 --> 00:40:27,740
+الجد نص من الجد من هذا الجانب فواحد منهم عنده
+
+440
+00:40:27,740 --> 00:40:33,900
+الـGene والاحتمالية نص لكل واحد منهم الأخت تبعت
+
+441
+00:40:33,900 --> 00:40:38,200
+الأب في الحالة هذه الاحتمالية إنه يكون عندها
+
+442
+00:40:38,200 --> 00:40:44,920
+الإصابة أو حامل الـGene الموروض هي نصالاحتمالية
+
+443
+00:40:44,920 --> 00:40:52,200
+يعني الـ Probability 50% لما تتزوج من شخص طبيعي من
+
+444
+00:40:52,200 --> 00:40:57,160
+الـ General population ماشي وعلى اختراد أن هذا
+
+445
+00:40:57,160 --> 00:41:01,560
+المرض أو الحالة هذه نادرة واحتمالية ما تكون موجودة
+
+446
+00:41:01,560 --> 00:41:10,040
+قليلة جداً فبنتج أنه راح تعطي هي لابنها أو بنتها
+
+447
+00:41:10,040 --> 00:41:15,600
+هنا اللي بتصير الاحتمالية الربعماشي، فهذه الـ
+
+448
+00:41:15,600 --> 00:41:22,480
+Probability، ماشي الـ Probability of being a
+
+449
+00:41:22,480 --> 00:41:26,900
+career يعني career عندك نسخة واحدة فهنا حاطين
+
+450
+00:41:26,900 --> 00:41:32,160
+النسب لمجموعة أفراد العائلة الأب والأم لازم يكونوا
+
+451
+00:41:32,160 --> 00:41:39,560
+حاملين الـ Other first degree relatives النُص لكل
+
+452
+00:41:39,560 --> 00:41:44,420
+واحد منهمالـ Second degree relative بتصير الرُبع
+
+453
+00:41:44,420 --> 00:41:54,820
+زي هنا، ماشي؟ سبب النقطة هذه سبب النقطة هذه أنه
+
+454
+00:41:54,820 --> 00:41:57,920
+الـ
+
+455
+00:41:57,920 --> 00:42:03,820
+يعني النقطة اللي بحكيها بهذه الطريقة أنه إحنا بثقة
+
+456
+00:42:03,820 --> 00:42:10,820
+بنحط النسب هذه لسببين، السبب الأول أنهالعلاقات
+
+457
+00:42:10,820 --> 00:42:15,200
+واضحة والسبب الثاني أنه المرض واضح واحنا عارفينه
+
+458
+00:42:15,200 --> 00:42:19,680
+وعارفين الـGene تبعه نقدر نروح نفحص عليه لما نكون
+
+459
+00:42:19,680 --> 00:42:24,140
+احنا عارفين وواثقين نعطي أرقام زي هيك ونكون
+
+460
+00:42:24,140 --> 00:42:30,180
+متأكدين من الموضوع لما نكون في حالة لأ مش Autism
+
+461
+00:42:30,180 --> 00:42:36,960
+or Recessiveماشي، أنه كشخص،
+
+462
+00:42:36,960 --> 00:42:44,360
+احنا، ماشي، عندنا إنسان مصاب، بس أنا، يعني مش زي
+
+463
+00:42:44,360 --> 00:42:48,060
+الـ Autosomal Recessive Mendelian Inheritance، One
+
+464
+00:42:48,060 --> 00:42:54,880
+Position، وخلاص، انتهيت، لأهنا بدي أستخدم الإحصاء
+
+465
+00:42:54,880 --> 00:43:00,240
+وأستخدم الاحتمالات بحيث أني أقدر أصل من خلال
+
+466
+00:43:00,240 --> 00:43:04,340
+معلومات يعني المجتمع ككل، نسبة حدوث المرض، نسبة
+
+467
+00:43:04,340 --> 00:43:08,920
+حدوثه، نتيجة كذا، نتيجة كذا، وكلنا نحط بعض الأرقام
+
+468
+00:43:08,920 --> 00:43:16,280
+على احتمالياتها، لما نيجي مثلا عائلة، أثنين شكلهم
+
+469
+00:43:16,280 --> 00:43:22,000
+مظهريا طبيعيين، عندهم حالة مصابة،من كلهم، طيب،
+
+470
+00:43:22,000 --> 00:43:26,440
+الطفل الثاني شو احتمالية إنه يكون مصاب بنفس
+
+471
+00:43:26,440 --> 00:43:31,240
+الطريقة؟ ها بدنا ناخد بعض الأمثلة ولا كده؟ فهنا
+
+472
+00:43:31,240 --> 00:43:37,460
+يعني اللي بيحطونيا هم الصراحة، يعني الجميل في
+
+473
+00:43:37,460 --> 00:43:41,820
+الكتاب والمرجع هذا إن الصورة بيكتبلك إذا الواحد
+
+474
+00:43:41,820 --> 00:43:47,020
+بنتبه عليها شريح كامل راح يلاقي فيها معلومات مفيدة
+
+475
+00:43:47,020 --> 00:43:55,420
+بشكل كبيرفيعني هنا كدراسة بقولّك
+
+476
+00:43:55,420 --> 00:44:04,020
+إذا Down Syndrome ماشي وطبعاً إله دخل بالـ…
+
+477
+00:44:04,020 --> 00:44:08,760
+يعني هو الـTrisomy 21 إله ممكن Non-disjunction
+
+478
+00:44:08,760 --> 00:44:14,160
+وTrisomy 21 وبشكل عادي إله دخل بالـMaternal Age
+
+479
+00:44:15,340 --> 00:44:20,040
+النسبة احتمالية إن الطفل الثاني يكون مصاب بنفس
+
+480
+00:44:20,040 --> 00:44:26,520
+الطريقة 1% عامًا بس إذا كان لقى الواحد روبرتسيان
+
+481
+00:44:26,520 --> 00:44:31,180
+Translocation النسبة أعلى بكتير يمكن 30 مرة أو 20
+
+482
+00:44:31,180 --> 00:44:35,620
+مرة أعلى إنه يكون الطفل الثاني كمان وايد حكينا
+
+483
+00:44:35,620 --> 00:44:43,090
+مثال على ذلك يعني الواحد لما نيجيبـ degree مثل هذا
+
+484
+00:44:43,090 --> 00:44:48,450
+وهو الإنسان المصاب وأخونا المصاب اللي اكتشفنا منه
+
+485
+00:44:48,450 --> 00:44:52,530
+المرض والعائلة جاي تسأل شو الوضع بالنسبة للقادم
+
+486
+00:44:52,530 --> 00:44:56,650
+بدي يكون الواحد يجمع معلومات قدر ما بيقدر ويكون
+
+487
+00:44:56,650 --> 00:45:01,610
+فاهم شو ال inheritance وعنده معلومات عليه الآن
+
+488
+00:45:01,610 --> 00:45:14,600
+المثال اللي حكيناه اللي هو نقطةإنه المثال
+
+489
+00:45:14,600 --> 00:45:18,280
+اللي قبل شويه الـ Autism and Recessive إذا أخدنا
+
+490
+00:45:18,280 --> 00:45:23,280
+Autism and Recessive كـ Disease، ماشي؟ لما نكون
+
+491
+00:45:23,280 --> 00:45:32,160
+عندي شخص مصاب، فأقول إن الأب والأم لازم يكونوا
+
+492
+00:45:32,160 --> 00:45:37,820
+حاملين، Obligate Carriersيعني هم بالتأكيد حاملين
+
+493
+00:45:37,820 --> 00:45:46,760
+عشان يجيبوا طفل مصعب الفكرة في الـA إنه نتيجة إن
+
+494
+00:45:46,760 --> 00:45:52,080
+هنا نص بنص الـ«one gene» «one copy affected»
+
+495
+00:45:52,080 --> 00:45:57,740
+وبالتالي لما يكون احتمالية عشان يظهر autosomal
+
+496
+00:45:57,740 --> 00:46:01,060
+recessive لازم يكون homozygous لازم يكون «too
+
+497
+00:46:01,060 --> 00:46:06,340
+affected» تصير احتمالية ربعبس الفكرة إن الربع هذه
+
+498
+00:46:06,340 --> 00:46:12,200
+أكيدة كيف يعني أكيدة؟ القصد فيها إن كاحتمالية إنها
+
+499
+00:46:12,200 --> 00:46:23,420
+ربع أكيد فأجى طفل مصاب و بعدين، شو اسمه؟ مثلا، هاي
+
+500
+00:46:23,420 --> 00:46:28,320
+عيلة ثانية بالـB بعد هيك جابوا ستة ذكور وإناس
+
+501
+00:46:28,320 --> 00:46:32,280
+فحاطينهم بشكل هذا جابوا ستة وكلهم طبيعيين
+
+502
+00:46:34,700 --> 00:46:39,880
+الآن صاروا سبعة عند العيالة هذه «شو إحتمالية الولد
+
+503
+00:46:39,880 --> 00:46:44,000
+الثامن يطلع مصاب؟» مايجيش واحد يقول «والله عشان
+
+504
+00:46:44,000 --> 00:46:49,680
+ستة طلعوا سليمين إذا راح تكون إحتمالية الإصابة
+
+505
+00:46:49,680 --> 00:46:55,380
+أقل» لأ، بتظلها ربع، ماشي، وهي يعني
+
+506
+00:46:55,380 --> 00:47:03,720
+الـIndependence of outcome يعني باللغة الإحصائية
+
+507
+00:47:04,470 --> 00:47:10,330
+بقولّك اللي هي إن الحدث العشوائي لا يحمل ذاكرة،
+
+508
+00:47:10,330 --> 00:47:17,230
+ماشي؟ فالفكرة في الموضوع أنا والله بفن ورا قطعة
+
+509
+00:47:17,230 --> 00:47:24,350
+نقود ويا إما بتطلع positive يعني وجه يا كتابي، يا
+
+510
+00:47:24,350 --> 00:47:29,850
+صورة يا كتابي فالاحتمالية إذا الأمور كويسة، النص
+
+511
+00:47:30,690 --> 00:47:35,390
+فأفرض أنا فنيتها عشر مرات وكل مرة تطلع وجه وجه وجه
+
+512
+00:47:35,390 --> 00:47:41,650
+وجه وجه وجه طب الـ 11 هل هي برضه راح تطلع وجه ولا
+
+513
+00:47:41,650 --> 00:47:47,350
+شو الاحتمالية؟ بقول بما أنه كل حدث غير مرتبط
+
+514
+00:47:47,350 --> 00:47:55,660
+بالثاني إذا النتيجةرح تكون برضه نص بالنسبة لقطعة
+
+515
+00:47:55,660 --> 00:48:02,900
+النقود إنها تكون وجه ولا كتابة لمن أنا سويتها فهي
+
+516
+00:48:02,900 --> 00:48:10,520
+الحالة A وB لما تكون الأمور معروفة ومفهومة، ماشي؟
+
+517
+00:48:10,520 --> 00:48:15,140
+لو ناخد خيار آخر أو احتمالية آخرة أو عائلة أخرى،
+
+518
+00:48:15,140 --> 00:48:21,500
+إنه أنا بالأولإمرأة اتزوجت رجل جابه طفل مصاب أنا
+
+519
+00:48:21,500 --> 00:48:28,600
+عرفت إنه هي حامل وهذه نسبة إنها تكون حامل للـ
+
+520
+00:48:28,600 --> 00:48:35,720
+Career للـ Genetic Mutation 100% اتزوجت إنسان أنا
+
+521
+00:48:35,720 --> 00:48:40,800
+لسه ما بعرف أو طلقت الجوز الأولاني وارتبطت بشخص
+
+522
+00:48:40,800 --> 00:48:51,300
+آخر الشخص الثاني ماشيأنا ماعندي معلومة عنه، فهؤلاء
+
+523
+00:48:51,300 --> 00:48:57,860
+العائلة الجديدة أتوا يسألوا «ما هي احتمالية أن
+
+524
+00:48:57,860 --> 00:49:04,360
+نجيب طفل مصاب؟» الأمر هنا برتبطبمعرفتنا يعني شو
+
+525
+00:49:04,360 --> 00:49:08,980
+احتمالية هذا الإنسان فهنا الوضع مختلف عن الحالة A
+
+526
+00:49:08,980 --> 00:49:15,880
+وB السبب إنه أنا هنا ما بعرف فديش هذا الإنسان عنده
+
+527
+00:49:15,880 --> 00:49:24,210
+فحاطين يعني هنا بتتغير الأمور بطريقتينفريقة
+
+528
+00:49:24,210 --> 00:49:28,470
+الأولى، أنا لازم أكون أعرف أو عندي معلومة تقريبًا
+
+529
+00:49:28,470 --> 00:49:35,890
+كام نسبة المرض في الـ General Population ماشي،
+
+530
+00:49:35,890 --> 00:49:42,650
+فاللي حاطينه هنا إنه هذا كمثال، ونأخذه كمثال
+
+531
+00:49:42,650 --> 00:49:49,390
+افتراضي إن الـGene هذا موجود في واحد من كل 22 بني
+
+532
+00:49:49,390 --> 00:49:57,770
+آدم فاحتمالية إنه يكونهذا الإنسان عنده جين وراثة
+
+533
+00:49:57,770 --> 00:50:11,370
+المرض هذا 1 على 22 ماشي، فالفكرة اللي لما
+
+534
+00:50:11,370 --> 00:50:20,400
+ناخد الآن يعني الاحتمالات زي ما شُفنا هنالما يكون
+
+535
+00:50:20,400 --> 00:50:27,040
+عندي two events إذا اعتبرناهم نسبهم مختلفة يعني
+
+536
+00:50:27,040 --> 00:50:37,960
+هنا نسبة كام copy من المرض هو نص، ماشي؟ وهنا 1 على
+
+537
+00:50:37,960 --> 00:50:46,260
+22، أظن نضربها ببعض وبيكون يعني بيحسبوا كيف تطلع
+
+538
+00:50:46,260 --> 00:50:55,440
+اللي هي 1 على 88يعني هنا أنا مرة واحدة بضرب النسب
+
+539
+00:50:55,440 --> 00:51:04,020
+الاحتمالية ببعض ونتيجتها يعني بتكون يعني لما نكون
+
+540
+00:51:04,020 --> 00:51:08,720
+يعني أنا الأرقام هنا بالضبط بالضبط في الشرح موجود
+
+541
+00:51:08,720 --> 00:51:13,860
+وحاطينه بالنسبة ليعني لما نقول هنا الـCarrier نسبة
+
+542
+00:51:13,860 --> 00:51:19,420
+100% بس هي الـCarrier عنده one copyماشي، لما أقول
+
+543
+00:51:19,420 --> 00:51:27,980
+1 من 22 عنده الـGene ف1 على 22 تربيع أو 1 على 22
+
+544
+00:51:27,980 --> 00:51:33,840
+يعني نسيت الرقم بحيث إنه لو ضربت احتمالية هذا
+
+545
+00:51:33,840 --> 00:51:40,940
+باحتمالية هذا بتطلع عندي 1 على 88 يعني الرقم هذا
+
+546
+00:51:40,940 --> 00:51:45,200
+هو المطلوب من الـCounselor إنه يقدمه بعد دراسة
+
+547
+00:51:45,200 --> 00:51:51,730
+طبيعة الوراثةوطبيعة المرض
+
+548
+00:51:51,730 --> 00:51:56,470
+وطبيعة الحالة لما أكون بالشكل الأول A وB أنا عارف
+
+549
+00:51:56,470 --> 00:52:00,930
+كل شيء وبالتالي بقدر أحسبه بشكل دقيق هنا بتصير في
+
+550
+00:52:00,930 --> 00:52:08,530
+عندي مجاهيل أكتر فالآن هنا أنا أظن كأنه كاتبين
+
+551
+00:52:08,530 --> 00:52:13,390
+عشان هي تطلع 88 إنه احتمالية إن الواحد يكون حامل
+
+552
+00:52:13,390 --> 00:52:19,530
+للجيل 1 ع 22فتطلع تضرب أربعة لربع و لا كذا تطلع
+
+553
+00:52:19,530 --> 00:52:25,170
+اللي هي 1 على 88 اللي دخلت فيها احتمالية الحدث
+
+554
+00:52:25,170 --> 00:52:33,490
+الآخر لأنه نسبة أخرى يعني مثال أنا باجي معاي قطعة
+
+555
+00:52:33,490 --> 00:52:38,430
+نقود وجه ولا كتابة وعندي حبة Nerd اللي هي المكعب
+
+556
+00:52:38,430 --> 00:52:44,490
+اللي عليه أرقام 0، 1، 1، 2، 3، 4، 6فبقول بمسك
+
+557
+00:52:44,490 --> 00:52:49,550
+اثنين هيك و بزدهم بصير أقول مثلا «شو احتمالية أن
+
+558
+00:52:49,550 --> 00:52:59,690
+يطلع لرقم ست و الفترة الفلوس وجه؟» مش صورة أو صورة
+
+559
+00:52:59,690 --> 00:53:07,550
+مش كتابة يعني مثلا فبقول الصورة هي نص و الـNerd أن
+
+560
+00:53:07,550 --> 00:53:12,910
+يكون اللي تطلع لرقم ست هي واحد من ستةفنص بواحد من
+
+561
+00:53:12,910 --> 00:53:16,970
+ست بيصير واحد باتناش بضربهم مع بعض فالفكرة بهذه
+
+562
+00:53:16,970 --> 00:53:22,270
+الطريقة عشان أنا أقدر شو الاحتمالية الملاحظ هنا
+
+563
+00:53:22,270 --> 00:53:33,090
+إنه إذا في مجهول ماشي يعني هنا اللي حكيناه إنه
+
+564
+00:53:33,090 --> 00:53:36,590
+صحيح أنا هنا كل الست الأولاد هدولة طلعوا سليمين
+
+565
+00:53:36,590 --> 00:53:38,430
+مافيش عندهم مشكلة
+
+566
+00:53:41,990 --> 00:53:49,850
+لما يكون عندى أنا العائلة فيها مجهول أنا مش عارف
+
+567
+00:53:49,850 --> 00:53:55,010
+شو عنده بالضبط لسه ماشي وأخدت الـ General
+
+568
+00:53:55,010 --> 00:54:01,010
+Population Percentage إذا المرأة هذه لما اتزوجت
+
+569
+00:54:01,010 --> 00:54:06,450
+الزلمة التاني جابت منه ست ولاد طلعوا كلهم سليمين،
+
+570
+00:54:06,450 --> 00:54:12,320
+ماشيلأن الـ Fact أنه يعني حقيقة أنه الـ 6 طلعوا
+
+571
+00:54:12,320 --> 00:54:19,240
+سليمين هذا بيخليني أغير نسبة شوه احتمالية أن يكون
+
+572
+00:54:19,240 --> 00:54:24,320
+هذا الإنسان فعلا سليم مية بالمية ومالوش يعني لو
+
+573
+00:54:24,320 --> 00:54:30,540
+كان مثلا قضيني الكلام أنه أنا 1 على 1 على 22 بكون
+
+574
+00:54:30,540 --> 00:54:37,600
+حامل للمرض لأنها general population بس لما يكونست
+
+575
+00:54:37,600 --> 00:54:44,240
+مرات يكون إنه هنا ما يبين إنه حامل معناته إنه أنا
+
+576
+00:54:44,240 --> 00:54:49,880
+بثقة أكبر بقول إنه هذا مش حامل للمرض وبالتالي لما
+
+577
+00:54:49,880 --> 00:54:53,660
+أعمل الحسبة تبعتي وتشوفوها، أقرأوها بقول هنا
+
+578
+00:54:53,660 --> 00:54:59,860
+تقريبًا 1 على 476 يعني تقريبًا 1 على 500 يعني خمس
+
+579
+00:54:59,860 --> 00:55:06,370
+مرات أقل احتمالية إن الطفل الجاي ييجي عنده مرضبسبب
+
+580
+00:55:06,370 --> 00:55:13,110
+أنه الـ 6 إخوان له الأشقاء كلهم سليمين وعنده أخ مش
+
+581
+00:55:13,110 --> 00:55:18,190
+شقيق من أمه من قبل كان عنده المرض هذا فهيك الواحد
+
+582
+00:55:18,190 --> 00:55:23,270
+بده يقراها ويده ينتبه إلها بدها الواحد يكون شاطر
+
+583
+00:55:23,270 --> 00:55:29,250
+بالرياضيات ودارس إحصاء وكويس ماشي أتأمل أني أكون
+
+584
+00:55:29,250 --> 00:55:33,890
+شرحت يعني شو معنى الـ slide هذا بأرقام بهذه
+
+585
+00:55:33,890 --> 00:55:34,410
+المعاني
+
+586
+00:55:37,940 --> 00:55:43,540
+النقطة اللي يعني هنا عقدوا الموضوع بإيش اسمه أكثر
+
+587
+00:55:43,540 --> 00:55:51,400
+قضية الـ Conditional Probability يعني إنه أنا حتى
+
+588
+00:55:51,400 --> 00:55:57,900
+أقيس شو إحتمالية إن حدث معين يكون بشكل معين ماشي
+
+589
+00:55:57,900 --> 00:56:08,850
+بصير، بدي يعني رياضياً أكون عندي قدرة على إنهأحلل
+
+590
+00:56:08,850 --> 00:56:14,650
+الموضوع بشكل سليم الأن
+
+591
+00:56:14,650 --> 00:56:22,030
+المثال اللي حطيناه قبل هو
+
+592
+00:56:22,030 --> 00:56:27,890
+Autism and Recessive لما كان عندي إنسان مصاب،
+
+593
+00:56:27,890 --> 00:56:33,890
+المصاب
+
+594
+00:56:33,890 --> 00:56:39,540
+في الحال هادىوالتزامن الـ Recessive المالز
+
+595
+00:56:39,540 --> 00:56:43,740
+والفيمالز زي بعض ولمّا طلع عندي إنسان مصعب فأنا
+
+596
+00:56:43,740 --> 00:56:48,740
+متأكد 100% إن الأب والأم Carriers هاي Fact، يعني
+
+597
+00:56:48,740 --> 00:56:55,060
+خلاص، انتهينا منها ناخد هنا مثلا موضوع ثاني وهنا
+
+598
+00:56:55,060 --> 00:56:58,180
+اللي هي X-linked recessive اللي هي الـHemophilia
+
+599
+00:56:58,180 --> 00:57:03,160
+اللي هي النعور اللي هي نقص factor eight و factor
+
+600
+00:57:03,160 --> 00:57:10,210
+nine أو factor nineوهي X-linked recessive فأنا
+
+601
+00:57:10,210 --> 00:57:16,890
+أفرض أنا عندي هنا السؤال
+
+602
+00:57:16,890 --> 00:57:25,070
+السؤال هذه المرأة اللي حاطين عليها سهم بتسأل شو
+
+603
+00:57:25,070 --> 00:57:34,290
+احتمالية أني أكون حامل لمرض النعور والهيموفيليا في
+
+604
+00:57:34,290 --> 00:57:42,140
+حالةإنه أنا عارف إن إثنين من إخوالها طلعوا
+
+605
+00:57:42,140 --> 00:57:47,440
+positive يعني إثنين من إخوالها طلعوا positive
+
+606
+00:57:47,440 --> 00:57:53,080
+وطلعوا عندهم المرض وهي بتسأل شو احتمالية تكون عندي
+
+607
+00:57:53,080 --> 00:58:02,420
+وأنا أنقله لأولادي وبناتي فهنا الموضوع ماشي في كذا
+
+608
+00:58:02,420 --> 00:58:15,170
+احتمالالكون أخوالها مصابين، ماشي، معناته إن على
+
+609
+00:58:15,170 --> 00:58:22,250
+الأقل لازم جدتها تكون مصابة فكلمة
+
+610
+00:58:22,250 --> 00:58:27,250
+conditional probability اللي هي يعني إنه أنا إذا
+
+611
+00:58:27,250 --> 00:58:36,080
+عندي كذا ظاهرةوكل واحدة بتحمل احتمالية مختلفة أني
+
+612
+00:58:36,080 --> 00:58:39,700
+أنا بالنسبة
+
+613
+00:58:39,700 --> 00:58:45,640
+لإحتمالية الاحتمالية العامة لحدوث هذا الشيء بما
+
+614
+00:58:45,640 --> 00:58:52,300
+فيها أنه فيه عدم يقين Uncertainty بشكل معين بتشوف
+
+615
+00:58:52,300 --> 00:58:57,120
+احتمالية كل الاحتمالات وبجمعهم بتطلع عندي
+
+616
+00:58:57,120 --> 00:59:04,540
+الاحتمالية الكلية فالمرأة هذه اللي هي هنا عليها
+
+617
+00:59:04,540 --> 00:59:10,280
+السهم اللي هي بتسأل السؤال طبعاً هنا عشان نعرف عن
+
+618
+00:59:10,280 --> 00:59:13,320
+أيش بحكي طبعاً هذا الـ Generation I، Generation
+
+619
+00:59:13,320 --> 00:59:19,960
+II، Generation III الـ Generation دايماً مثلاً II
+
+620
+00:59:19,960 --> 00:59:26,040
+هذا الطفل الأول، الطفل الثاني، هذا جوز البنت هذه
+
+621
+00:59:26,660 --> 00:59:30,020
+وهذا الطفل الثالث أو الـ الـ الـ في الـ generation
+
+622
+00:59:30,020 --> 00:59:35,340
+هذا الشخص الرابع فبعطي أرقام للـ generation وبعطي
+
+623
+00:59:35,340 --> 00:59:40,920
+يعني هذول بالـ Roman numbers وبعطي أرقام للأفراد
+
+624
+00:59:40,920 --> 00:59:44,680
+بترتيب معين عشان أعرف عن مين أنا بحكي وماشي اللي
+
+625
+00:59:44,680 --> 00:59:55,480
+بحكي فالآن المرأة هذه اللي بتسأل ماشي خوالها
+
+626
+00:59:55,480 --> 01:00:02,000
+مصابيناللي هم 2A و2B و2B و2B و2B و2B و2B و2B و2B
+
+627
+01:00:02,000 --> 01:00:08,400
+و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B
+
+628
+01:00:08,400 --> 01:00:09,920
+و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B
+
+629
+01:00:09,920 --> 01:00:10,600
+و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B
+
+630
+01:00:10,600 --> 01:00:11,000
+و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B
+
+631
+01:00:11,000 --> 01:00:16,360
+و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B
+
+632
+01:00:16,360 --> 01:00:24,120
+و2B و2B و2B و2B و2B و2B و2
+
+633
+01:00:24,230 --> 01:00:28,890
+يعني هذه البنت هنا اللي بدأت تتجوز وتسأل «شو وضعي
+
+634
+01:00:28,890 --> 01:00:34,170
+أنا؟» «شو اللي بيصير عندي؟» «شو كذا؟» فإن إخوالها
+
+635
+01:00:34,170 --> 01:00:40,830
+أكيد مصابي، طب إمها مصابة ولا لأ؟ فهنا حاطين
+
+636
+01:00:40,830 --> 01:00:48,430
+احتمال إن الإم مش مصابة أو الإم مصابةوبعد أن أمها
+
+637
+01:00:48,430 --> 01:00:52,830
+مصابة، هل هي مصابة أو ليس مصابة؟ فصار عندي ثلاث
+
+638
+01:00:52,830 --> 01:00:58,970
+خيارات، ثلاث احتمالات إنه ممكن الجد أصيبت، بس ما
+
+639
+01:00:58,970 --> 01:01:05,230
+نقلت لبنتها فبنتها طلعت Clear، Normal وبالتالي 100
+
+640
+01:01:05,230 --> 01:01:14,630
+% الحفيدة ما راح تكون مصابة ممكن الأم الجد مصابة،
+
+641
+01:01:14,630 --> 01:01:19,940
+نقلت لبنتهاوبنتها الحالة الأولى هو إنها ما نقلتش
+
+642
+01:01:19,940 --> 01:01:26,520
+لحفيدتها للجدة فهذا احتمال ثاني وفي احتمال تالت لأ
+
+643
+01:01:26,520 --> 01:01:30,200
+إنه نقلت لهجي فانت صار عندي تلت خيارات و تلت
+
+644
+01:01:30,200 --> 01:01:36,520
+احتمالات ماشي الانسان
+
+645
+01:01:36,520 --> 01:01:42,260
+اللي هنا بيسموها الـ Joint Probabilities ماشي ال
+
+646
+01:01:42,260 --> 01:01:50,040
+.. ال ..الاحتمالية للحالة الأولى أنه يكون هاي أكيد
+
+647
+01:01:50,040 --> 01:01:53,920
+عندها one copy فهنا احتمالية أنها عندها اللي تكون
+
+648
+01:01:53,920 --> 01:02:00,960
+ال copy راح تصير نص، ماشي؟ والاحتمالية أنه تاخد من
+
+649
+01:02:00,960 --> 01:02:08,240
+أمها برضه احتمالية نص، ماشي؟ فالـ Joint
+
+650
+01:02:08,240 --> 01:02:15,750
+Probability بدنا نضربهم في بعضنص في نص أربعة يعني
+
+651
+01:02:15,750 --> 01:02:22,610
+هدولة الاحتماليات اللي يعني أنا لو جدة عندها one
+
+652
+01:02:22,610 --> 01:02:29,430
+copy ماشي بنتها أنها تكون يعني هي نص يعني واحدة من
+
+653
+01:02:29,430 --> 01:02:33,950
+اثنتين البنت أن تكون عندها ال copy بتقول
+
+654
+01:02:33,950 --> 01:02:40,210
+احتماليتها ربع واتزوجت من شخص آخر وحفيدة الأصل
+
+655
+01:02:40,210 --> 01:02:45,740
+الواحد يقول ثمنفإحنا نحكي برقم عشوائي، لأ، بتقول
+
+656
+01:02:45,740 --> 01:02:49,960
+ثمن، بس هذا غلط، مش المظبوط إن الواحد يقولها بس
+
+657
+01:02:49,960 --> 01:02:55,160
+ثمن ويحطها بهذا الشكل، بحط الواحد الاحتمالات
+
+658
+01:02:55,160 --> 01:03:02,420
+الثلاثة وبدرب الاحتماليات الخطوات تبعتهم، ماشي،
+
+659
+01:03:02,420 --> 01:03:11,320
+وهنا بطبق مبدأ إنه أنا عندي يعنيمعرفة إنه فيه
+
+660
+01:03:11,320 --> 01:03:18,200
+أشخاص آخرين ما عندهم مش ماشي يعني بظل إنه فيه
+
+661
+01:03:18,200 --> 01:03:23,280
+احتمال إنه شخص مش مصاب حسب يا ما الـ General
+
+662
+01:03:23,280 --> 01:03:27,640
+Population أو زي ما حكينا بالمثال قبل شوية اللي هو
+
+663
+01:03:27,640 --> 01:03:31,380
+إنه لما العيلة التانية جابوا ست أفراد ماعندهم مش
+
+664
+01:03:31,380 --> 01:03:38,680
+إصابة فاحتمالية الإصابة أقل الـ الـ النتيجةإنه
+
+665
+01:03:38,680 --> 01:03:41,860
+يعني هنا
+
+666
+01:03:41,860 --> 01:04:05,180
+الـ………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………
+
+667
+01:04:07,480 --> 01:04:17,260
+ولمّا تأخذ، يعني هي بالأصل 1 على 64، وبعدين 1 على
+
+668
+01:04:17,260 --> 01:04:23,900
+34 وهنا الاحتمال الثاني، يعني احتمالية أن الجد
+
+669
+01:04:23,900 --> 01:04:30,260
+مصابي اتجوزت واحد مش مصاب، وبعدين البنت اتجوزت
+
+670
+01:04:30,260 --> 01:04:38,120
+واحد مش مصاب، وهي أجت البنتالبنت بتسأل، طبعاً هي
+
+671
+01:04:38,120 --> 01:04:42,180
+كمان بدأت تتجوز بواحد مش مصاب، هيك الأصل احتمالية
+
+672
+01:04:42,180 --> 01:04:46,920
+أنه تنقل المرض 1 على 43، هي احتمالية هذه الحالة،
+
+673
+01:04:46,920 --> 01:04:53,900
+هذه الخطوة الـ B بتكون احتماليتها كمان 1 على 34
+
+674
+01:04:54,900 --> 01:04:59,580
+واحتمالية إن الجد مصابي بس ماعتدتش لبنتها والبنت
+
+675
+01:04:59,580 --> 01:05:06,420
+بعدين ماعتدتش للحفيدة هو 16 على 17 يعني 32 على 34
+
+676
+01:05:06,420 --> 01:05:11,640
+الفكرة أنه بعد ما عرفنا معلومات أكتر بقدر أصير
+
+677
+01:05:11,640 --> 01:05:17,840
+أعمل رياضيات وأحصاء بشكل أفضل والنتيجة
+
+678
+01:05:17,840 --> 01:05:25,650
+النهائية أنه لما أجمع هذول النتائجواحد على أربعة
+
+679
+01:05:25,650 --> 01:05:28,510
+وثلاثين وواحد على أربعة وثلاثين وستاشر على سبعتاش
+
+680
+01:05:28,510 --> 01:05:33,930
+بيطلعلي 100% الاحتمال الكلي فهدولة اللي بيسموها
+
+681
+01:05:33,930 --> 01:05:38,310
+Bayesian calculation وهدولة أنواع من الرياضيات
+
+682
+01:05:38,310 --> 01:05:47,290
+بنصير نسويهم عشان نحسب شو احتمالية أنه البنت تكون
+
+683
+01:05:47,290 --> 01:05:53,720
+يعني مصابة وشو احتمالية أنها تنقلها لأهلهافهنا
+
+684
+01:05:53,720 --> 01:05:59,020
+دايمًا يعني هذا
+
+685
+01:05:59,020 --> 01:06:04,100
+مثال على مرض زي الـ Hemophilia واحتمال يعني على
+
+686
+01:06:04,100 --> 01:06:11,740
+الأمور الرياضية اللي فيها بالنسبة كوراثة جين
+
+687
+01:06:11,740 --> 01:06:17,180
+مفهوم، Single gene، Mendelian أنا عارف عنه وبعرف
+
+688
+01:06:17,180 --> 01:06:25,680
+كيفإن شاء الله إذا بقول يعني بالنسبة للـSlides هذه
+
+689
+01:06:25,680 --> 01:06:32,540
+إذا مافهمتوش مني 100% بسأل الـOrganizer واللي
+
+690
+01:06:32,540 --> 01:06:38,440
+معاكم يعني هو لو قريت اللي في الكتاب بمفهومه بشكل
+
+691
+01:06:38,440 --> 01:06:42,400
+جيد يمكن أنا مش شاطر كتير في الشبه، بالذات في هذا
+
+692
+01:06:42,400 --> 01:06:48,210
+الموضوعوالشغل الثاني أنه بدك واحد بيفهم بالأحصاء
+
+693
+01:06:48,210 --> 01:06:54,090
+بيفهم بالاحتمالات يدخل معاك واحد واحدة ويكون يشوف
+
+694
+01:06:54,090 --> 01:07:02,250
+ليش بنسويها بهذه الطريقة وبتكون أنه الـ الـ الـ
+
+695
+01:07:02,250 --> 01:07:08,030
+النتائج بتكون بهذا الشكل الاحتمال أو التعقيد اللي
+
+696
+01:07:08,030 --> 01:07:18,440
+بعد ذلك هو يعنيحالات بتتكلموا عن مرض
+
+697
+01:07:18,440 --> 01:07:22,820
+أنا لسه مش عارف يعني الحالة الأولى Autism and
+
+698
+01:07:22,820 --> 01:07:27,920
+Recessive وأنا عارف عنه وعارف الجيل وأنا متأكد أن
+
+699
+01:07:27,920 --> 01:07:31,400
+الأب والأم لازم يكونوا Carriers حتى يحدث المرض
+
+700
+01:07:31,400 --> 01:07:36,800
+وأنا عارف الـInheritance تبعه فهذه قصة حلوة لما
+
+701
+01:07:36,800 --> 01:07:42,900
+يكون الزوج الثاني مش معروف يصير الموضوع أعقبأما
+
+702
+01:07:42,900 --> 01:07:47,900
+لما يكون عندى كمان مجاهيل أكثر بيصير بده إحصاء
+
+703
+01:07:47,900 --> 01:07:52,660
+أصعب وبالنتيجة بتكون يعني معقدة أكتر بدى الواحد
+
+704
+01:07:52,660 --> 01:08:02,100
+يتبع معاهم بالنسبة لأرقام كيف بتكون الـ… الـ… الـ…
+
+705
+01:08:02,100 --> 01:08:08,050
+الـB-degree الثالث أو النموذج الثالث أو الرابعهو
+
+706
+01:08:08,050 --> 01:08:15,830
+إذا عائلة عندهم مرض نادر أو مش معروف ننتبه بس بقول
+
+707
+01:08:15,830 --> 01:08:22,070
+في الـ «سلايد» هذا إنه أنا جزء من تعاملي مع
+
+708
+01:08:22,070 --> 01:08:28,490
+الاحتمالية هنا بكون باعتمد على رقمين الرقم الأول
+
+709
+01:08:28,490 --> 01:08:36,900
+شوه احتمالية إنه المرضهو نتيجة جين موروث في
+
+710
+01:08:36,900 --> 01:08:40,840
+المجتمع يعني زي اللي حكينا عنه الـ Hemophilia و
+
+711
+01:08:40,840 --> 01:08:43,960
+الـ Bq لأن الـ Autism is recessive أو Existently
+
+712
+01:08:43,960 --> 01:08:47,700
+recessive و لا كذا، ماديش نسبة و واحد في المية و
+
+713
+01:08:47,700 --> 01:08:52,300
+واحد في العشرة و واحد في الألف و بدنا نلاحظ هذا
+
+714
+01:08:52,300 --> 01:08:59,020
+يتم توريطه بس في عندي احتمالية ثانية اللي هي New
+
+715
+01:08:59,020 --> 01:09:05,360
+Mutation من حالهابتنشأ وشوه احتمالية أنه تنشأ هذه
+
+716
+01:09:05,360 --> 01:09:11,320
+الـ mutation الجديدة يعني بيكون مش نتيجة ورافة
+
+717
+01:09:11,320 --> 01:09:19,220
+لازمة من الأباء والأمهات فهنا التعقيد راح يصير أنه
+
+718
+01:09:19,220 --> 01:09:27,440
+الاحتمالية الجين في المجتمع وهنا بيسموه H ماشي؟
+
+719
+01:09:30,260 --> 01:09:37,740
+والاحتمالية إنه New Mutation نسمينه الـ Mu فبصير
+
+720
+01:09:37,740 --> 01:09:44,480
+عندي أرقام مختلفة وهنا حاطين مثال
+
+721
+01:09:44,480 --> 01:09:50,020
+X-Linked Genetic Lethal Disorder شو يعني؟ يعني هنا
+
+722
+01:09:50,020 --> 01:09:56,620
+حالة إن هذا الذكر اللي مصاب لأنه X-Linked
+
+723
+01:09:56,620 --> 01:10:04,120
+RecessiveLethal يعني ما راح يعيش أو الـ «دوشين
+
+724
+01:10:04,120 --> 01:10:08,920
+مسكولر دستروفي» الأطفال اللي بولدوا من أولها
+
+725
+01:10:08,920 --> 01:10:14,440
+بيبينوا ضعاف، عضلاتهم ضامرة ويتوبك على سن العشر
+
+726
+01:10:14,440 --> 01:10:19,040
+سنين نسبة عالية جدا، كلهم بموتوا العشر سنين قبل ما
+
+727
+01:10:19,040 --> 01:10:22,800
+يبلغوا قبل ما يصير في احتمالية أنه يخلفوا هم
+
+728
+01:10:22,800 --> 01:10:27,560
+بحالهم فالـ «دوشين مسكولر دستروفي» في حالة زي هيك
+
+729
+01:10:28,300 --> 01:10:38,080
+الـ … الـ … الـ … الوجود طفل عنده هذه الحالة
+
+730
+01:10:38,080 --> 01:10:43,800
+فمتيجي الأهل يسأله «طب، و بعد ذلك المرة الثانية،
+
+731
+01:10:43,800 --> 01:10:48,820
+شو الاحتماليات؟ و شو كذا؟» أنا هنا بصير أدخل إنه
+
+732
+01:10:48,820 --> 01:10:56,260
+فيه احتمال إنه الـ … الـ … الأم، ماشي، هي career
+
+733
+01:10:58,120 --> 01:11:03,240
+هنا زي في الاحتمال رقم 2 بس الاحتمال إنه لأ هي مش
+
+734
+01:11:03,240 --> 01:11:07,280
+career وإنها صارت mutation في الطفل نفسه بس بما
+
+735
+01:11:07,280 --> 01:11:11,200
+أنه X-linked و One copy وصار mutation وال copy
+
+736
+01:11:11,200 --> 01:11:17,640
+طلعت مضروبة بصير إن هنا يعني ال mutation عنده وهي
+
+737
+01:11:17,640 --> 01:11:24,280
+تحدث بالنسبة ميو بالتالي يعني بدنا نتكلم عن
+
+738
+01:11:24,280 --> 01:11:28,430
+احتماليه بهذه الطريقة يعني هناإن الأم والأب ما حدش
+
+739
+01:11:28,430 --> 01:11:31,410
+منهم career ما حدش عنده إشي فهي mutation في الطفل
+
+740
+01:11:31,410 --> 01:11:41,950
+نفسه هنا الأم هي عبارة عن شو اسمه career وبالتالي
+
+741
+01:11:41,950 --> 01:11:47,830
+نقلة المرض لإبنها في احتمالية ثالثة إن مثلا لو
+
+742
+01:11:47,830 --> 01:11:55,490
+جدته يعني عنده من أخواله حدا مصابماشي، يعني هذه
+
+743
+01:11:55,490 --> 01:11:59,350
+المرأة هنا حامل بس إحنا ماعرفناش إذا في لأخوان
+
+744
+01:11:59,350 --> 01:12:05,730
+آخرين، يعني أخوان الولد هذا كان حد توفى بهذا
+
+745
+01:12:05,730 --> 01:12:11,550
+المرض، ماشي، ويعني كان في شخص آخر، فإذا كان من
+
+746
+01:12:11,550 --> 01:12:14,970
+أخوان المصابين بتصير إنه آه والله الجد كمان كانت
+
+747
+01:12:14,970 --> 01:12:19,010
+مصابة، فبنلاحظ إنه
+
+748
+01:12:21,830 --> 01:12:23,970
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+749
+01:12:23,970 --> 01:12:24,270
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+750
+01:12:24,270 --> 01:12:24,310
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+751
+01:12:24,310 --> 01:12:24,630
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+752
+01:12:24,630 --> 01:12:29,030
+الـ الـ
+
+753
+01:12:29,030 --> 01:12:33,430
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+754
+01:12:33,430 --> 01:12:35,150
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+755
+01:12:35,150 --> 01:12:35,550
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+756
+01:12:35,550 --> 01:12:37,250
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+757
+01:12:37,250 --> 01:12:38,070
+الـ الـ
+
+758
+01:12:43,650 --> 01:12:48,050
+الجد هي اللي كانت مصابة نقلتها للبنتها ومن بنتها
+
+759
+01:12:48,050 --> 01:12:54,150
+للحفيد أصابته بالمرض فاحتمالية الثلاث حالات هذه
+
+760
+01:12:54,150 --> 01:12:58,310
+راح تيجي تتجمع لـ 100% لأن هاي كل اللي بصوا بالـ
+
+761
+01:12:58,310 --> 01:13:02,790
+Combinations ولمّا نيجي نحسب شو هو احتمالية الطفل
+
+762
+01:13:02,790 --> 01:13:06,550
+اللي بعده أو شو هو احتمالية إنه كذا بتحسب مين اللي
+
+763
+01:13:06,550 --> 01:13:10,690
+طالب الاستشارة ممكن نعطيه الأرقام حسب الدراسة
+
+764
+01:13:12,890 --> 01:13:19,590
+فيعني نتيجة الشغل هذا بنلاقي إنه مثلًا لو ناخد
+
+765
+01:13:19,590 --> 01:13:27,050
+موضوع زي الـ Birth Defect اللي هم يعني العيوب
+
+766
+01:13:27,050 --> 01:13:31,410
+الخلقية بالنسبة للأشياء زي Cleft Lip ولا Cleft
+
+767
+01:13:31,410 --> 01:13:33,750
+Palate ولا Congenital Heart Disease ولا كده
+
+768
+01:13:33,750 --> 01:13:42,970
+الـConsanguinity بتزيد نسبة الاحتمالية هذهفلو جينا
+
+769
+01:13:42,970 --> 01:13:50,030
+أخدنا ألف وليد جديد، الموليد الجدد إن يكون فيه
+
+770
+01:13:50,030 --> 01:13:57,310
+birth defect من هذه الأنواع، ماشي تطلع تقريبًا 1.5
+
+771
+01:13:57,310 --> 01:14:07,730
+%، 15 حالة لما نكون الزواج متباعد، يعني 1% إذا كان
+
+772
+01:14:07,730 --> 01:14:12,520
+في الـFirst Cousin Marriage أكثر من الضعفبتصير
+
+773
+01:14:12,520 --> 01:14:21,260
+احتمالية أن يكون فيه birth defect فهو نتلعت 36 في
+
+774
+01:14:21,260 --> 01:14:31,160
+الألف وإذا الطفل يعني couple زوج أجاهم أول طفل كان
+
+775
+01:14:31,160 --> 01:14:39,080
+مصاب ماشي لو فيه ألف من هدول العيلة ألف عيلة كان
+
+776
+01:14:39,080 --> 01:14:46,160
+عندهم طفل مصاب أولإنه يكون مصاب ثاني بيكون تلاتين
+
+777
+01:14:46,160 --> 01:14:52,040
+في الألف يعني تلاتة بالمية يعني ضعف هدولة ولمّا
+
+778
+01:14:52,040 --> 01:14:57,300
+يكون فيه Consanguinity يعني هنا تقريبًا أربع مرات
+
+779
+01:14:57,300 --> 01:15:03,540
+ونص أقل شويه من خمس مرات ماشي بيصير الزيادة فإيه
+
+780
+01:15:03,540 --> 01:15:07,200
+يعني النقطة اللي بدنا نفهمها هنا جزء من الموضوع
+
+781
+01:15:07,200 --> 01:15:14,440
+أنهدواج الأقارب بزيد احتمالية إن يكون فيه أمراض
+
+782
+01:15:14,440 --> 01:15:23,190
+وراثية تظهر وبيكون يعني رياضياً وهنا كتجربةمن
+
+783
+01:15:23,190 --> 01:15:31,710
+إحصائية ودراسة للموليد حسب درجة قرابة العائلة بين
+
+784
+01:15:31,710 --> 01:15:36,530
+الزوجين وحسب التاريخ السابق إنه كان هناك إصابة من
+
+785
+01:15:36,530 --> 01:15:46,050
+هذا النوع أو لا كلها تزيد النقطة هذه يعني الفصل
+
+786
+01:15:46,050 --> 01:15:53,500
+هذاالكلام أنا بظن عن ناحية مهمة جداً ولازم يكون في
+
+787
+01:15:53,500 --> 01:15:59,220
+كل وزارة الصحة في كل مجموعة صحية بتهتم بـ
+
+788
+01:15:59,220 --> 01:16:07,140
+Population معينة في مجتمع إنه يكون فيه ناس بتعمل
+
+789
+01:16:07,140 --> 01:16:11,340
+Genetic Counseling وجزء من الـ Genetic Counseling
+
+790
+01:16:11,340 --> 01:16:19,480
+إنه كمان نعملنعطي تقييم إحصائي رقمي بشو احتمالية
+
+791
+01:16:19,480 --> 01:16:23,860
+إنه يكون الإنسان حامل للـGene شو احتمالية الإصابة
+
+792
+01:16:23,860 --> 01:16:30,440
+في أي شخص حسب العلوم والرياضيات والأرقام بالشكل
+
+793
+01:16:30,440 --> 01:16:37,500
+اللي حكيناوبتختلف إذا أنا بعرف أنه بثقة أو شيء
+
+794
+01:16:37,500 --> 01:16:42,680
+مجهول فيه ولا مافيش بحط كل الاحتمالات وبدرسها
+
+795
+01:16:42,680 --> 01:16:55,080
+ويعني على ضوءها بصير أتكلم بشكل علمي في أسئلة؟ في
+
+796
+01:16:55,080 --> 01:17:01,060
+حد عنده استفسار النقطة هذه، النقاط هنا أنا بقترح
+
+797
+01:17:01,490 --> 01:17:07,410
+الكتاب عندكم كمان يعني أنا حاولت أفهم الـ «general
+
+798
+01:17:07,410 --> 01:17:14,290
+idea» وطريقة الـ «approach» يعني اللي هي أنه بدي
+
+799
+01:17:14,290 --> 01:17:21,010
+أسير حتى لما يسألوني شو احتمالية كذا لشخص معين بدي
+
+800
+01:17:21,010 --> 01:17:26,200
+أخد كل شجرة العيلة بدي أشوف شو احتمالية الـهل هي
+
+801
+01:17:26,200 --> 01:17:32,260
+زي الـGeneral Population لهذا الموضوع؟ ولا فيه
+
+802
+01:17:32,260 --> 01:17:36,400
+محددات أكثر؟ وبدخل كل الاحتمالات البعض وبطلع
+
+803
+01:17:36,400 --> 01:17:45,160
+الرقم؟ فضل، إذا حد عنده سؤال يعني
+
+804
+01:17:45,160 --> 01:17:48,880
+يا دكتور، هذه النقاط مطالبين فيها أنه في الامتحان
+
+805
+01:17:48,880 --> 01:17:52,000
+نتوسع ولا فقط نلتزم باللي أنت شرحت فيها هذه
+
+806
+01:17:52,000 --> 01:17:58,890
+النقاط؟مش داخل في الموضوع، وش اسمه؟ يعني، هيك ما
+
+807
+01:17:58,890 --> 01:18:04,770
+بدك تكوني فاهماني يعني، لما حكيت والله أنا معايا
+
+808
+01:18:04,770 --> 01:18:11,150
+فيدي قطعة فلوس وجه ولا كتابة وحجر نرد عليه ست
+
+809
+01:18:11,150 --> 01:18:16,330
+أوجه، من واحد لستة، شو احتمالية تطلعلي رقم ست زائد
+
+810
+01:18:16,330 --> 01:18:23,000
+يطلعلي الفلوس تطلعلي وجهي؟ ماشي؟فاهم علي؟ فبدك
+
+811
+01:18:23,000 --> 01:18:26,640
+تكون ليه واحد عطناش، هيك المفروض يعني يبدوا الواحد
+
+812
+01:18:26,640 --> 01:18:30,740
+شوية رياضيات يكون فاهمانها، فالمطالبين مش
+
+813
+01:18:30,740 --> 01:18:37,120
+المطالبين، أنا الصراحة يعني اللي بدي أحاول أسويه
+
+814
+01:18:37,120 --> 01:18:44,320
+اللي هو الموضوع إنه زي ما الـ US M&E كاتبي لكم إن
+
+815
+01:18:44,320 --> 01:18:49,940
+هذا بيجي، بدي أقول، بدي أجيب زيه، ماشي؟ فهذه ناحية
+
+816
+01:18:49,940 --> 01:18:57,880
+ثانيةالناحية الثالثة، يعني اللي شفتيها بتتكلم عن
+
+817
+01:18:57,880 --> 01:19:00,500
+الـPosterior Probability والـConditional
+
+818
+01:19:00,500 --> 01:19:05,260
+Probability يعني هدولة مفاهيم في الإحصاء أنا بهمن
+
+819
+01:19:05,260 --> 01:19:10,540
+الواحد يكون فهما عن المفهوم، ماشي؟ الرقم والخساب
+
+820
+01:19:10,540 --> 01:19:16,560
+والضرب يعني مرات حتى الواحد بغلط فيه وبنقل الأرقام
+
+821
+01:19:16,560 --> 01:19:22,220
+ولّا، بس الفكرة أنه بدي الواحد يحطها كمثالماشي،
+
+822
+01:19:22,220 --> 01:19:26,240
+ويحطها كشيء مفهوم، هم اللي حطوا مثالين كلها
+
+823
+01:19:26,240 --> 01:19:29,760
+تقريبًا Autosomal Recessive أو إذا فيه lethal ولا
+
+824
+01:19:29,760 --> 01:19:33,100
+كده فعندنا إيش اسمه Conditional Probability ولا
+
+825
+01:19:33,100 --> 01:19:40,480
+كده، هسة أتأمل إنه إذا قريتي، تفهمي، ماشي، وإذا
+
+826
+01:19:40,480 --> 01:19:44,810
+الواحد فهم، مش غلطوإذا من 100 سؤال حطيتلي سؤال على
+
+827
+01:19:44,810 --> 01:19:49,330
+إيش زي هيك، يمكن يطلعت شويه صعب، يمكن كذا، ما هو
+
+828
+01:19:49,330 --> 01:19:52,950
+عشان نفرق الشاطر من اللي أقل شطارة، يعني إيش بده
+
+829
+01:19:52,950 --> 01:19:58,510
+أسوء؟ ماشي، أما مطلوب، مش مطلوب، لأ، ما بقدرش
+
+830
+01:19:58,510 --> 01:20:02,090
+أجاوب، عارفش، كل شيء بحقك –أميسيا يا دكتور، أنا
+
+831
+01:20:02,090 --> 01:20:05,310
+كان قصدي إنه هل نتوسع فيه أكتر ولا نلتزم بس باللي
+
+832
+01:20:05,310 --> 01:20:11,830
+شرحته أو كذا؟لأ، كل مثال من الأمثل اللي جبت لهم
+
+833
+01:20:11,830 --> 01:20:17,270
+الصور تبعتهم صراحة معاه شرح أنا شفته سهل جدا يعني
+
+834
+01:20:17,270 --> 01:20:22,270
+بحكي الـ «إنت المفهوم اللي بده أحد يعرفه اللي هو
+
+835
+01:20:22,270 --> 01:20:25,970
+conditional probability و posterior probability»
+
+836
+01:20:25,970 --> 01:20:31,290
+الـconditional إنه أنا بسير أحط الاحتمالات كلهم
+
+837
+01:20:31,290 --> 01:20:41,090
+وبالأخير مجموعهم لازم يكون واحدلازم يكون لأنه لما
+
+838
+01:20:41,090 --> 01:20:46,690
+يحصل حدث معين فاحتمالية حدوثه صارت واحد بس الطرق
+
+839
+01:20:46,690 --> 01:20:51,290
+اللي قدت لهذا الأمر بتكون مختلفة يعني هي مرات هذه
+
+840
+01:20:51,290 --> 01:20:57,370
+كنة المصاري أو الـ Dice اللي هو الـ Nerd اللي من
+
+841
+01:20:57,370 --> 01:21:02,950
+ست أوجه يطلع وجهه و لا كتابه و لا كذا و لا كذايعني
+
+842
+01:21:02,950 --> 01:21:08,830
+هذه القريبة من الموضوع هذا وبناخدها كأمثلة بسيطة
+
+843
+01:21:08,830 --> 01:21:13,750
+يعني بس الـ الـ الـ لما نكون مثلا الحادثين
+
+844
+01:21:13,750 --> 01:21:21,770
+المختلفة يعني هنا الأم اللي اتجوزت واحد مش معروف
+
+845
+01:21:21,770 --> 01:21:29,410
+فهو مصاب ولا مش مصاب الأم زي قطعة الفلوس يا وجهها
+
+846
+01:21:29,410 --> 01:21:34,080
+كتابة وأنا عارف أن يا وجهها كتابةما فيش غيرهم وإذا
+
+847
+01:21:34,080 --> 01:21:38,520
+الأمور عادلة وما فيش فيها غش راح يكون الاحتمالية
+
+848
+01:21:38,520 --> 01:21:45,000
+نص الحدث الثاني اللي هو زي حجر نر يعني الاحتمالية
+
+849
+01:21:45,000 --> 01:21:50,600
+واحد من ست صارت ما كانت واحد من اتنين ماشي ومرات
+
+850
+01:21:50,600 --> 01:21:55,440
+يعني ممكن صياغة السؤال يكون يعطيكي clue أو يعطيكي
+
+851
+01:21:55,440 --> 01:22:02,290
+مفهوم معين إنه شيء معين حدث، ماشي؟وقضية الـ
+
+852
+01:22:02,290 --> 01:22:07,430
+«memorylessness
+
+853
+01:22:07,430 --> 01:22:15,510
+of independent events» فهي قضية مفهومة معروفة يعني
+
+854
+01:22:15,510 --> 01:22:22,530
+مثلا عيلة ست مرات جابت ولاد ذكور شو احتمالية الولد
+
+855
+01:22:22,530 --> 01:22:28,910
+السابع يطلع عنده ذكر؟ شو رأيك؟ نص، بيبقى له نص
+
+856
+01:22:28,910 --> 01:22:34,030
+دايمابظله نص بما هو، لو مليون مرة طلع ذكر وكل مرة
+
+857
+01:22:34,030 --> 01:22:39,410
+ذكر وبعدين يجي واحد يقول لأ اللي مرة هذه لازم يطلع
+
+858
+01:22:39,410 --> 01:22:42,370
+ذكر لأنه مليون مرة من قبل طلع ذكر لأ ما بتمشي
+
+859
+01:22:42,370 --> 01:22:47,470
+الأمور هكذا، هذا إذا الأمور ما لها دخلت بعض وتكون
+
+860
+01:22:47,470 --> 01:22:52,010
+الأمور محكومة ومعروفة، بس إذا أنا عندي إشي مجهول
+
+861
+01:22:52,010 --> 01:22:57,940
+وبدرسهماشي ويصير مثلًا أنه لو احتملنا أنه
+
+862
+01:22:57,940 --> 01:23:02,700
+اعتبرناها الأمور independent وكل واحد بالاصل fifty
+
+863
+01:23:02,700 --> 01:23:09,590
+fifty شو احتمالية يعني أنا إذا بتنتبهي دكتورةلما
+
+864
+01:23:09,590 --> 01:23:16,790
+نجي نعمل تجربة ونقول والله بنحط الـ… بتاخدتوا
+
+865
+01:23:16,790 --> 01:23:19,830
+الـResearch Principles وبتحط اللي بيسموه الـNull
+
+866
+01:23:19,830 --> 01:23:23,450
+Hypothesis والـAlternative Hypothesis وبتعملوا
+
+867
+01:23:23,450 --> 01:23:26,510
+الـStatistical Test وبتطلعوا الـP-Value اللي هي
+
+868
+01:23:26,510 --> 01:23:31,770
+نسبة التأكد إن هذا الأمر مش نتيجة صدفةبتكون نسبة
+
+869
+01:23:31,770 --> 01:23:39,890
+المطلوبة إنه يكون عندى الاحتمالية أقل من 5% هذه
+
+870
+01:23:39,890 --> 01:23:44,070
+الاحتمالية الصدفة المقبولة للدراسات العلمية
+
+871
+01:23:44,070 --> 01:23:51,570
+فالموضوع بتلاقي أنا بقول إذا بنجيب إنه واحد عشان
+
+872
+01:23:51,570 --> 01:23:56,230
+تقول بشكل علمي مقبول بهذه الطريقة إنه لما أفن
+
+873
+01:23:56,230 --> 01:24:02,250
+لقطعة الفلوس تطلع وجههأو صورة مش كتابة لازم أفنها
+
+874
+01:24:02,250 --> 01:24:07,170
+على الأقل ست مرات وكل مرة تطلع وجه، وجه، وجه، وجه،
+
+875
+01:24:07,170 --> 01:24:08,330
+وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه،
+
+876
+01:24:08,330 --> 01:24:13,030
+وجه، وجه،
+
+877
+01:24:13,030 --> 01:24:15,830
+وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه،
+
+878
+01:24:15,830 --> 01:24:16,450
+وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه،
+
+879
+01:24:16,450 --> 01:24:22,530
+وجه، وجه، وجه، وجه، وجه، وجه، وجه، وج
+
+880
+01:24:27,700 --> 01:24:33,900
+ثلاث مرات، معناتها صارت إيه اسمه؟ إتناش و نص
+
+881
+01:24:33,900 --> 01:24:39,460
+بالمية أربع مرات، ست و ربع بالمية حتى تكون تحت
+
+882
+01:24:39,460 --> 01:24:43,120
+الخمس بالمية، بديك خمس مرات، ست مرات عشان تثبت إن
+
+883
+01:24:43,120 --> 01:24:47,020
+الـP-Value بتطلع بهذا الشكل فإحنا نتكلم من هذه
+
+884
+01:24:47,020 --> 01:24:54,360
+النواحي أنا مش إحنا course probability وإحصاء وكذا
+
+885
+01:24:54,360 --> 01:25:01,500
+المهم الـGeneral Ideaالـ Counselor اللي بعمل
+
+886
+01:25:01,500 --> 01:25:08,640
+Counseling لعيلة لازم يكون عنده آلات وفهم واستيعاب
+
+887
+01:25:08,640 --> 01:25:16,980
+على إنه يعمل الدراسة الإحصائية ويطلع تقدير ماشي
+
+888
+01:25:16,980 --> 01:25:23,200
+ويبلغ الأهل فيه، هذه النقطة المطلوبةما مثل ما يا
+
+889
+01:25:23,200 --> 01:25:29,100
+دكتور الله يحييكم في أسئلة في نفس المثال أو في نفس
+
+890
+01:25:29,100 --> 01:25:31,460
+الأشياء مش مطلوب ولا مش مطلوب؟ يعني ما انتوا
+
+891
+01:25:31,460 --> 01:25:35,820
+سألوني مش هذا السؤال آه لأ لأ كله واضح إن شاء الله
+
+892
+01:25:35,820 --> 01:25:42,000
+طيب الفصل الثاني اليوم
+
+893
+01:25:44,060 --> 01:25:49,700
+على موضوع برضه الـ Counselor اللي دخل فيه ويمكن من
+
+894
+01:25:49,700 --> 01:25:53,280
+أهم جوانب العملية في قضية الـ Genetic Diseases
+
+895
+01:25:53,280 --> 01:25:59,820
+أحيانًا في مواضيع اللي بيسموها أنه يكون «Prenatal
+
+896
+01:25:59,820 --> 01:26:03,460
+Diagnosis and Screening» يعني هي شو نعمل في
+
+897
+01:26:03,460 --> 01:26:07,380
+الأمراض الوراثية في المجتمع وكيف نقاومها وكيف
+
+898
+01:26:07,380 --> 01:26:08,360
+نتعامل معاها
+
+899
+01:26:11,320 --> 01:26:15,860
+الأمثلة على الأشياء هذه أنا بقول خلّينا نحطها
+
+900
+01:26:15,860 --> 01:26:22,120
+بثلاث جوانب في النقطة
+
+901
+01:26:22,120 --> 01:26:26,660
+الأولى، خلّينا قبل ما نبدأ من الأشياء المهمة
+
+902
+01:26:26,660 --> 01:26:31,860
+للتعامل مع الأمراض الوراثية أول شيء الـPremarital
+
+903
+01:26:31,860 --> 01:26:37,000
+diagnosis وScreening يعني اللي هو فحص الطبي قبل
+
+904
+01:26:37,000 --> 01:26:44,490
+الزواج، ماشي؟أحيانًا كثيرًا يعني إحنا بالقانون في
+
+905
+01:26:44,490 --> 01:26:48,810
+الأردن مأذون هو أتوقع كمان إن شاء الله في غزة
+
+906
+01:26:48,810 --> 01:26:54,710
+بيكونوا بيطبقوا نفس الأشياء أو أشياء زيها قضية إنه
+
+907
+01:26:54,710 --> 01:26:58,350
+مثلًا اللي بدهم يتزوجوا لازم يروح على مختبر طب
+
+908
+01:26:58,350 --> 01:27:03,430
+ويعملوا CBC وتشوف الواحد عشان مرض أنيميا البحر
+
+909
+01:27:03,430 --> 01:27:08,900
+الأبيض المتوسطاللي هو الـ Thalassemia ماشي حتى
+
+910
+01:27:08,900 --> 01:27:12,400
+نشخصهم بنروح بنقولهم روحوا يعملوا فحص الزواج قبل
+
+911
+01:27:12,400 --> 01:27:17,460
+الزواج وبندور على Microcytosis اللي هي مثال يعني
+
+912
+01:27:17,460 --> 01:27:22,940
+دليل على في الغالب على الـ Microcytic اللي هو يعني
+
+913
+01:27:22,940 --> 01:27:28,640
+career state للـ Thalassemiaوإذا إثنين هم، إذا
+
+914
+01:27:28,640 --> 01:27:32,980
+واحد بس اللي عنده الحالة نقولهم الله يسهل عليكم
+
+915
+01:27:32,980 --> 01:27:37,540
+اتجوزوا وكملوا الله يرزقهم ويفتح عليكم أما إن إذا
+
+916
+01:27:37,540 --> 01:27:43,000
+إثنين حاملين وإثنين عندهم ال possibility فهنا
+
+917
+01:27:43,000 --> 01:27:46,780
+بتصير الاحتمالية إنه ندخل في مشاكل ويكون الطفل
+
+918
+01:27:46,780 --> 01:27:52,180
+عنده تلسيميا وهذا غلب عليه وعلى أهله وعلى مجتمعه
+
+919
+01:27:52,180 --> 01:27:56,200
+وعلى كذايعني الـ Thalassemia Child، It's a long
+
+920
+01:27:56,200 --> 01:28:01,200
+life disease وما بيكونش حياتهم طبيعية وصحية
+
+921
+01:28:01,200 --> 01:28:06,120
+وبتغلبوا ومرضانين وبياخدوا نقل دم وبيدخلوا بـ
+
+922
+01:28:06,120 --> 01:28:12,820
+Heart Failure يعني بتعذّب هو وأهله فممكن واحد يقول
+
+923
+01:28:12,820 --> 01:28:21,710
+إن أنا أسوي إشي يعني ما قبل الزواج حتىهذا وارد
+
+924
+01:28:21,710 --> 01:28:25,890
+وممكن إنه مثلا إذا في عائلة أو في مجتمع في عندهم
+
+925
+01:28:25,890 --> 01:28:32,750
+احتمالية مرض معين ممكن أنا أدور على إنه يكون تطابق
+
+926
+01:28:32,750 --> 01:28:38,090
+الشخصين بشكل يمنع هذا المرض الموضوع الثاني حكينا
+
+927
+01:28:38,090 --> 01:28:45,430
+برضه عن جانب منه اللي هو قضية اللي هو موضوع عند
+
+928
+01:28:45,430 --> 01:28:51,770
+الولادةمن أول ما يولد بسوي Screening فيه يعني حتى
+
+929
+01:28:51,770 --> 01:28:56,450
+الآن حتى في دول متقدمة إحنا أنا حكينا الأردن مثلا
+
+930
+01:28:56,450 --> 01:29:01,670
+بنعمل على ثلاث أشياء بـVery Simple Test وطجة واحدة
+
+931
+01:29:01,670 --> 01:29:06,030
+وشغلتها بسيطة في المختبر بس بيعملوها لكل الأطفال
+
+932
+01:29:06,350 --> 01:29:12,250
+اللي هم الـ Creditism أو الـ Hypothyroidism نفحص
+
+933
+01:29:12,250 --> 01:29:17,550
+الـ TSH بدم الجنين وبالتالي بنقدر نعرف إذا عنده
+
+934
+01:29:17,550 --> 01:29:22,650
+نعطيها الـ Thyroxine شغل Simple، Easy، من تنقضه من
+
+935
+01:29:22,650 --> 01:29:29,610
+مرض سيء جداً، ماشي؟ الـ Thyroid Disease الـ PQ،
+
+936
+01:29:29,610 --> 01:29:35,050
+برضه بنعمله، دخلناها، والفكرة فيه إنه إذا أكل لوغ
+
+937
+01:29:37,370 --> 01:29:42,090
+بالفنال الألاذين بالذات كـ Mino Acid بيكون الطفل
+
+938
+01:29:42,090 --> 01:29:45,190
+طبيعي ماعنده أي مشكلة بالنسبة لـ Mental
+
+939
+01:29:45,190 --> 01:29:49,430
+retardation ولا أي شيء ثاني فهي بنعملها وحكاية الـ
+
+940
+01:29:49,430 --> 01:29:54,170
+HIV برضه بيعملوه من باب الـ Screening في دول تانية
+
+941
+01:29:54,170 --> 01:29:58,270
+مثلا بيعملوا Screening على الـ بعد الولادة على كل
+
+942
+01:29:58,270 --> 01:30:03,930
+الـ Immune Deficiencies فبرضه يعني عندهم إنكانات
+
+943
+01:30:03,930 --> 01:30:10,600
+وعندهميعني طرق أنه كمختبر نفحص لكل الموليد الجدد
+
+944
+01:30:10,600 --> 01:30:14,860
+ونسوي الـ Screening ضمن بقية الـ Screening للأشياء
+
+945
+01:30:14,860 --> 01:30:20,140
+التانية النقطة اللي راح نتكلم عنها في الفصل هذا هي
+
+946
+01:30:20,140 --> 01:30:27,800
+جوانب نفحص على الجنين هو لسه بطن أمه والأمر يعني
+
+947
+01:30:27,800 --> 01:30:34,760
+سواء كأخلاقيراح نتكلم عن جوانب الأخلاقية في محاضرة
+
+948
+01:30:34,760 --> 01:30:43,160
+قادمة موضوع كيف، شو نعمل بالنسبة إذا شخصنا إشي
+
+949
+01:30:43,160 --> 01:30:48,320
+يعني في ثقافات، وحكينا إحنا مضطرين الاحترام
+
+950
+01:30:48,320 --> 01:30:54,400
+للثقافات المختلفة القوانين المختلفة، الأديان
+
+951
+01:30:54,400 --> 01:31:01,960
+المختلفةالأديان، الأديان يعني الإسلام ويعني مثلًا
+
+952
+01:31:01,960 --> 01:31:07,220
+بين أخواننا المسيحيين الكاتوليك مثلًا الإجهاض حرام
+
+953
+01:31:07,220 --> 01:31:12,580
+أحنا في الإسلام ومثلًا الكاتوليكيين الإجهاض فقط
+
+954
+01:31:12,580 --> 01:31:18,760
+حلال لإنقاذ حياة الأمة يعني للمحافظة على الأصل أنت
+
+955
+01:31:18,760 --> 01:31:25,120
+تضحي بالفرع هيك يعني بأرضه على أساس أنه الجنين فرع
+
+956
+01:31:25,120 --> 01:31:30,740
+من أمهوإنه يعني بندخل في موضوع حتى بالنسبة كإجهاد
+
+957
+01:31:30,740 --> 01:31:35,160
+في الإسلام في قضية متى نفخ الروح اللي هو إنسان
+
+958
+01:31:35,160 --> 01:31:40,240
+منفصل أو مش منفصل وندخل في الموضوع هذا بس في أشياء
+
+959
+01:31:40,240 --> 01:31:46,560
+نقدر نسويها وخصوصًا إذا ثقافة ولا مجتمع يعني في
+
+960
+01:31:46,560 --> 01:31:51,240
+الدول الغربية في تفاوت في أمريكا مثلًا على قضية
+
+961
+01:31:51,240 --> 01:31:57,820
+الإجهادالنساء بتقولّك، ها الحمل طالما هو لسه بطني
+
+962
+01:31:57,820 --> 01:32:01,840
+هو جزء مني وانا مسئول عنه وانا اللي بتحمل وانا
+
+963
+01:32:01,840 --> 01:32:07,660
+اللي بسوي وبالتالي يعني حتى لو بالشهر التاسع وبدها
+
+964
+01:32:07,660 --> 01:32:15,260
+تعمل إجهاد يعني هذا كتلة دم ولحم ومالوش قيمة وانا
+
+965
+01:32:15,260 --> 01:32:21,630
+خلصت من ورم وخلاصماشي، فالإجهاد يعني هو في كل
+
+966
+01:32:21,630 --> 01:32:28,150
+المستنكر بعد التأخير يعني أصل إذا بدأت قررت إجهاد
+
+967
+01:32:28,150 --> 01:32:33,250
+الأول تعمله بفترة مبكرة يعني قبل ما يتخلق ولا يبين
+
+968
+01:32:33,250 --> 01:32:39,430
+إنه إنسان أو قريب من الإنسان بس بيظل إنه يعني في
+
+969
+01:32:39,430 --> 01:32:46,100
+أطباء وفي كذا إنه إذاالتي أثبتت إن الطفل عنده خلل
+
+970
+01:32:46,100 --> 01:32:52,340
+وراثي معين أو مرض معين سيء وعامل مشكلة إن أنا ممكن
+
+971
+01:32:52,340 --> 01:32:58,000
+أعمل إجهاض وأخلص منه فبيهمني إن أنا أشخص طبعاً
+
+972
+01:32:58,000 --> 01:33:01,820
+واحد بدخل في جوانب أخلاقي بيضل يدخل فيها خضية إنه
+
+973
+01:33:01,820 --> 01:33:06,540
+طب شو عرفك يعني لو إنسان عنده مرض منغولية Down
+
+974
+01:33:06,540 --> 01:33:12,720
+Syndrome يعني أنت هيك من برا بتقول هوالمعذب هو
+
+975
+01:33:12,720 --> 01:33:20,380
+بعذب، هو مريض يعني تقريبًا زي ما النازيين في
+
+976
+01:33:20,380 --> 01:33:25,260
+ألمانيا قرروا أنه يعني خلصوهم من معاناتهم وقتلوهم
+
+977
+01:33:25,260 --> 01:33:30,580
+كلهم ويعني يتبحوا أي واحد عنده مثل هذا الأشياء
+
+978
+01:33:30,580 --> 01:33:35,720
+وكذلك يعني قضية أنه في فترة الحمل ممكن أحيانًا
+
+979
+01:33:35,720 --> 01:33:43,540
+يكون عندنايعني آليات للتعامل ممكن إجهاد، ممكن
+
+980
+01:33:43,540 --> 01:33:49,660
+مثلًا الطفل جنين وعنده congenital heart disease
+
+981
+01:33:49,660 --> 01:33:56,480
+وعنده ما هو اسمه؟ اللي ممكن يجروله عملية وهو لسه
+
+982
+01:33:56,480 --> 01:34:01,370
+جنينفي بعض المرات مثلًا «هيدروبس فيتاليس» وصار
+
+983
+01:34:01,370 --> 01:34:08,670
+عنده تكسر دم بنقوله «للجنين في بطن أمه دم» يعني
+
+984
+01:34:08,670 --> 01:34:14,290
+مرات بتكون فيه خيارات ممكن أعملها حسب الحالة وحسب
+
+985
+01:34:14,290 --> 01:34:18,310
+الـ «حسب
+
+986
+01:34:18,310 --> 01:34:22,350
+الوضع» يعني طبعًا مع العائلة، «شو صار معاهم؟» «إيش
+
+987
+01:34:22,350 --> 01:34:30,980
+نحن بنتكلم؟» والفكرة أنه أنالما أقول بعمل تفتيش
+
+988
+01:34:30,980 --> 01:34:38,540
+على شيء معين بقول بعمله Screening من الأشياء اللي
+
+989
+01:34:38,540 --> 01:34:44,460
+مثلا يعني كويسة وممكن أحياناً أعملها أحنا راح نحكي
+
+990
+01:34:44,460 --> 01:34:47,960
+على شو الأشياء اللي ممكن أعملها خلينا بعد شوية
+
+991
+01:34:47,960 --> 01:34:55,810
+بنرجع للـSlide اللي قبلالـ Slide هذا اللي هو رقم
+
+992
+01:34:55,810 --> 01:35:04,950
+17-1 Figure 17-1 بيحكينا عن ثلاث أنواع من أنواع
+
+993
+01:35:04,950 --> 01:35:10,350
+الفحوصات اللي أستخدمها كـ Screening عند الحمل عشان
+
+994
+01:35:10,350 --> 01:35:15,490
+أشوف الطفل مصاب أو غير مصاب أو الجنين مصاب أو غير
+
+995
+01:35:15,490 --> 01:35:22,270
+مصاب الجنين، اللي لسه هو مرحلة الجنين الـ Aاللي هو
+
+996
+01:35:22,270 --> 01:35:29,470
+مسمّينه «amniotic fluid sampling» ماشي، الـ
+
+997
+01:35:29,470 --> 01:35:33,710
+«amniocentesis»
+
+998
+01:35:33,710 --> 01:35:38,550
+هيك يسميه الـ «parietal synthesis» أو كده اللي هي
+
+999
+01:35:38,550 --> 01:35:45,810
+يعني البذل أو اللي صاحب العينة فالمثال الأول A إنه
+
+1000
+01:35:45,810 --> 01:35:54,220
+أنا باجي بالـ «Ultrasound» Guidedبدخل نيدل في بطن
+
+1001
+01:35:54,220 --> 01:36:01,360
+الأم، ببعد عن الجنين، ببعد عن المشيمة، ببعد عن أي
+
+1002
+01:36:01,360 --> 01:36:07,320
+إشي بيخوف، وبدخل النيدل في الـFluid المحيط
+
+1003
+01:36:07,320 --> 01:36:12,440
+بالجنين، وباخد منه خلايا، باخد منه Fluid، في
+
+1004
+01:36:12,440 --> 01:36:19,290
+الغالب Fluid، بكون بقدر أفحصه للأشياء هذه مثلًا،زي
+
+1005
+01:36:19,290 --> 01:36:22,830
+الـ Chemical نتال زي الـ Alpha-Fetoprotein راح
+
+1006
+01:36:22,830 --> 01:36:28,250
+نحكي عنه الـ Chromosome الـ الـ Components الـ
+
+1007
+01:36:28,250 --> 01:36:31,930
+Chromosome الـ Enzyme Parameters و الـ DNA
+
+1008
+01:36:31,930 --> 01:36:38,490
+Analysis ممكن أبعثها لأشياء كثيرة هنا الـ يعني هذه
+
+1009
+01:36:38,490 --> 01:36:45,130
+مشتركة و جزء منها ممكن يعني هو في الغالب من الـ
+
+1010
+01:36:46,770 --> 01:36:51,450
+الجنين نفسه، بس إيه له ارتباط بالأم وفيه ارتباط
+
+1011
+01:36:51,450 --> 01:36:56,270
+يعني ممكن الـFluid هذا أقدر أفحص فيه أشياء وفي
+
+1012
+01:36:56,270 --> 01:37:01,270
+أحيان مابقدرش أفحص فيه أشياء تانية يعني حسب شو
+
+1013
+01:37:01,270 --> 01:37:07,230
+المشكلة، وأنا كيف أفحص هل هذا الـSample مناسب لهذا
+
+1014
+01:37:07,230 --> 01:37:12,650
+الفحص ولا لأ؟ الطريقة الثانية، اللي هي Quranic
+
+1015
+01:37:12,650 --> 01:37:20,610
+Villai Samplingهنا أنا بدي أخد من الـ villas تبع
+
+1016
+01:37:20,610 --> 01:37:25,990
+الكوريون اللي هي برضه من الجنين بس أنا باخد cells
+
+1017
+01:37:25,990 --> 01:37:35,330
+أكثر، cells يعني أنا متأكد إنها من الجنين وبتكون
+
+1018
+01:37:35,330 --> 01:37:41,630
+أحسن إن أفحص عليها زي كروموزومات، زي جينات، زي
+
+1019
+01:37:41,630 --> 01:37:47,140
+أشياءفالـ الـ الـ الـ هنا العيب أو الملاحظ أن أنا
+
+1020
+01:37:47,140 --> 01:37:51,800
+بدي أضطر أخد من الماشيمة نفسها فأنا بدي أخذق
+
+1021
+01:37:51,800 --> 01:37:55,940
+الماشيمة يعني الماشيمة ممكن تنزف ممكن يكون فيها
+
+1022
+01:37:55,940 --> 01:38:02,180
+مشكلة ممكن أنا أخرّب في الحالة هذه فهذا موضوع أعقد
+
+1023
+01:38:02,180 --> 01:38:08,100
+فهنا زي ما أنتم شايفين الـ Sonar حاطينه من فوقوالـ
+
+1024
+01:38:08,100 --> 01:38:17,160
+«حاطين» بحطه يعني «سيرنج» أو Wire، «كانيولا» عشان
+
+1025
+01:38:17,160 --> 01:38:22,140
+أنا أدخل لجوا أكثر وبعدين باخد الـ «سامبل» حيث أنا
+
+1026
+01:38:22,140 --> 01:38:26,840
+أكون متأكد إن أنا واصل مش بس بالـ «سونار» عمياني
+
+1027
+01:38:26,840 --> 01:38:30,840
+هيك على الـ«أمانيوسنتيسيس»
+
+1028
+01:38:30,840 --> 01:38:34,340
+لأ، أنا هنا بدأ أصل لهذه المكان، للـ«بلاسنتا»،
+
+1029
+01:38:34,340 --> 01:38:41,800
+للمشيمة، وبدأ أخد عينة منهاهذا أسلوب ثاني أحصل
+
+1030
+01:38:41,800 --> 01:38:48,860
+Sample من الجنين عشان أقدر أعمل دراسات معينة
+
+1031
+01:38:48,860 --> 01:38:56,080
+الموضوع الثالث اللي هو مربوط بإنه أنا الأيام هذه
+
+1032
+01:38:56,080 --> 01:38:58,560
+تعرفوا كلكم اللي هو موضوع الـ In Vitro
+
+1033
+01:38:58,560 --> 01:39:05,260
+Fertilization التلقيح خارج الجسم خارج الرحم أو في
+
+1034
+01:39:05,260 --> 01:39:11,520
+المختبرالتلقيح هذا بدأ من خلال النساء اللي عندهم
+
+1035
+01:39:11,520 --> 01:39:15,800
+مثلًا تسكير في القنوات Fallopian tubes أو أنابيبي
+
+1036
+01:39:15,800 --> 01:39:20,940
+مسكرة فعندها الـ الـ عندها الـ egg طبيعي والرحم
+
+1037
+01:39:20,940 --> 01:39:27,120
+طبيعي من تاني والمبايظ كويسة والزلمة كويس بس الـ
+
+1038
+01:39:27,120 --> 01:39:32,620
+Spare ما بقدر يصل لل egg فبناخد الـ egg برا وبن ..
+
+1039
+01:39:32,620 --> 01:39:37,360
+شو اسمه؟بنعرضها للـSperms وبصير الـFertilization
+
+1040
+01:39:37,360 --> 01:39:44,100
+وانا في المختبر يعني عادةً هذه الشغل بالـIn vitro
+
+1041
+01:39:44,100 --> 01:39:50,260
+fertilization اللي لما يكون عندهم في الـPetri dish
+
+1042
+01:39:50,260 --> 01:39:55,180
+أو في الـCell culture medium بيقدر الواحد تحت
+
+1043
+01:39:55,180 --> 01:39:58,900
+الماكروسكوب يشوف تطور البني آدم تبدأ خلية واحدة
+
+1044
+01:39:58,900 --> 01:40:03,520
+تنقسم خليتين، أربعة، تمانية، ستاشربصير doubling،
+
+1045
+01:40:03,520 --> 01:40:07,700
+doubling، doubling كل يوم وبصير يعني متوقع مثلًا
+
+1046
+01:40:07,700 --> 01:40:14,740
+ولهن أسماء لـPlastomere مثلًا بستنوا لما تصير
+
+1047
+01:40:14,740 --> 01:40:19,100
+الخلايا ثمان خلايا يعني بيكون في مرحلة معينة وهذا
+
+1048
+01:40:19,100 --> 01:40:26,140
+كله لسه قبل ما نرجع الطفل أو الجنين للرحم في الأم
+
+1049
+01:40:26,140 --> 01:40:33,090
+أن أخذ خلية من هذه الخلايا، ماشي؟أحيانًا بعد ما
+
+1050
+01:40:33,090 --> 01:40:36,030
+يصير الـ Implantation أو إذا هذه بتصير يعني
+
+1051
+01:40:36,030 --> 01:40:40,590
+بيستنوا عليها أكثر جوا الـ Test tube لأنه بتصير
+
+1052
+01:40:40,590 --> 01:40:45,150
+على شكل كرة وهذه هي اللي بيصير الـ Implantation في
+
+1053
+01:40:45,150 --> 01:40:54,630
+الرحم ممكن أني أخذ يعني هنا أحنا حكينا أخذ عينة
+
+1054
+01:40:54,630 --> 01:41:01,990
+بهذه الطريقة من هذه المرحلة أو أستنى أكثر وأخذيعني
+
+1055
+01:41:01,990 --> 01:41:05,410
+هذه المنطقة الكتلة هذه هي اللي راح تكون الجنين
+
+1056
+01:41:05,410 --> 01:41:10,190
+ماشي الـ Inner Cell Mass هي اللي راح تكون الجنين
+
+1057
+01:41:10,190 --> 01:41:13,770
+بهجي على منطقة بعيد عنها وبكون تحت الـ Microscope
+
+1058
+01:41:13,770 --> 01:41:18,250
+أنا بشوف أي خلية باخد وبعدين بوديها على المختبر
+
+1059
+01:41:18,250 --> 01:41:23,410
+بدور على أي شيء اللي بديهافيعني هدولة الثلاث
+
+1060
+01:41:23,410 --> 01:41:27,830
+خيارات الأمانيوسينتيسيس
+
+1061
+01:41:27,830 --> 01:41:33,110
+الـ Villas Sample «فوريونيك فيلاي» Sampling
+
+1062
+01:41:33,110 --> 01:41:33,970
+«فوريونيك فيلاي» Sampling «فوريونيك فيلاي»
+
+1063
+01:41:33,970 --> 01:41:35,030
+Sampling «فوريونيك فيلاي» Sampling «فوريونيك
+
+1064
+01:41:35,030 --> 01:41:36,090
+فيلاي» Sampling «فوريونيك فيلاي» Sampling
+
+1065
+01:41:36,090 --> 01:41:39,650
+«فوريونيك فيلاي» Sampling «فوريونيك فيلاي»
+
+1066
+01:41:39,650 --> 01:41:39,730
+«فوريونيك فيلاي» Sampling «فوريونيك فيلاي»
+
+1067
+01:41:39,730 --> 01:41:42,950
+Sampling «فوريونيك
+
+1068
+01:41:42,950 --> 01:41:50,430
+فيلاي» Sampling «فوريونيك فيلا
+
+1069
+01:41:51,510 --> 01:41:59,210
+وعبارة عن يعني حتى الواحد يتخذ قرار بيكون منتبه
+
+1070
+01:41:59,210 --> 01:42:07,210
+لكل الاحتمالات وكل النقاط مثلا،
+
+1071
+01:42:07,210 --> 01:42:11,790
+من الأشياء اللي تعمل الـ Alpha-Fetoprotein الـ
+
+1072
+01:42:11,790 --> 01:42:14,930
+Alpha-Fetoprotein يعني انتوا يمكن عندكم معلومة عنه
+
+1073
+01:42:14,930 --> 01:42:21,320
+هو من الـ يعني بنعتبرهم tumor antigensالـ Alpha
+
+1074
+01:42:21,320 --> 01:42:26,140
+-Fetoprotein عندنا في الـ Adult يعني في الناس
+
+1075
+01:42:26,140 --> 01:42:31,060
+العاديين بعدين في بعض أنواع السرطانات سواء liver
+
+1076
+01:42:31,060 --> 01:42:35,260
+cancer، GI cancer يخلّي هذا البروتين يعلق
+
+1077
+01:42:35,260 --> 01:42:42,000
+والبروتين هذا بعلق هو في الأصل عبارة عن بديل
+
+1078
+01:42:42,000 --> 01:42:46,410
+الألبومينبكون موجود خلال الـ embryonic period
+
+1079
+01:42:46,410 --> 01:42:51,010
+ويكون وظيفته يخل السوائل جوا الدور الدمائي، ما
+
+1080
+01:42:51,010 --> 01:42:56,590
+يخلّيها تطلع فالـ Alpha-Fetoprotein هذا موجود وفي
+
+1081
+01:42:56,590 --> 01:43:02,310
+الحملة الطبيعية، في المرحلة الجنينية، بكون طبيعي
+
+1082
+01:43:02,310 --> 01:43:11,740
+أن يكون موجودماشي، فلما نكون يعني من الأشياء
+
+1083
+01:43:11,740 --> 01:43:17,500
+الثانية اللي بتسببه زيادة في الحمل الـ Neural Tube
+
+1084
+01:43:17,500 --> 01:43:22,040
+Defects اللي هي Spinal بفدة أو Unencephaly أو
+
+1085
+01:43:22,040 --> 01:43:26,350
+مشاكل طبعاً هذه جزء منهبالـ Embryology لازم تكونوا
+
+1086
+01:43:26,350 --> 01:43:30,410
+أخدتوا كيف إنسان بتشكل و الـ neural tube بتلم
+
+1087
+01:43:30,410 --> 01:43:34,110
+وبتضم بعد ما هيك وتصير two ridges بيصير زي الخندق
+
+1088
+01:43:34,110 --> 01:43:37,890
+وبعدين ال tube بتكون وبعدين بيلف على بعضه وبتكون
+
+1089
+01:43:37,890 --> 01:43:42,810
+الدماغ وبتكون باقية الأشياء فإذا في عندنا anomaly
+
+1090
+01:43:42,810 --> 01:43:52,990
+بالـ neuronal tubeماشي، بيصير عندى، شو اسمه؟ الـ
+
+1091
+01:43:52,990 --> 01:43:57,550
+Alpha-Fetoprotein بيصير إفرازه بتصير مستوى أعلى
+
+1092
+01:43:57,550 --> 01:44:06,050
+فإذا أخدت Ammoniac Fluid Alpha-Fetoprotein كمؤشر
+
+1093
+01:44:06,050 --> 01:44:11,750
+على وجود Neuronal Tube Defect ويعني عيلة خايفين من
+
+1094
+01:44:11,750 --> 01:44:17,220
+هذا الموضوع عندهم طفل كان أنانكفلياللي هو من فوق،
+
+1095
+01:44:17,220 --> 01:44:21,420
+يعني مالوش دماغ من فوق أو من تحت إشي بيسموه Spinal
+
+1096
+01:44:21,420 --> 01:44:26,580
+Bifida و لا كده فبيجي واحد بيقول خلّينا نسحب شوية
+
+1097
+01:44:26,580 --> 01:44:30,780
+Fluid و هذا الفحص بسيط وسهل مغلبش للـ Alpha
+
+1098
+01:44:30,780 --> 01:44:39,920
+-Fetoprotein بعمله وبعدين بقرر عليه فالفكرة كمان
+
+1099
+01:44:39,920 --> 01:44:44,860
+إنه الـ Alpha-Fetoprotein لما نيجي نقرر كدهش الـ
+
+1100
+01:44:44,860 --> 01:44:49,780
+Normal Levelجزء من الموضوع أنه الواحد يكون عارف
+
+1101
+01:44:49,780 --> 01:44:55,000
+كام شهر الأنثى هذه أو الأم هذه الحامل صار حاملها
+
+1102
+01:44:55,000 --> 01:44:58,580
+هذا فلمّا
+
+1103
+01:44:58,580 --> 01:45:03,560
+يكون الـ Alpha-Fetoprotein يعني في adult وإنسان
+
+1104
+01:45:03,560 --> 01:45:06,800
+بعد الولادة ومنذ الكبيرة وصار الـ Alpha
+
+1105
+01:45:06,800 --> 01:45:09,340
+-Fetoprotein عالي بقول يمكن هذا liver cancer،
+
+1106
+01:45:09,340 --> 01:45:13,580
+colon cancer مش عارف إيش عنده، ففي الـFetal period
+
+1107
+01:45:14,340 --> 01:45:18,100
+يمكن الـ Fetal Blood Contamination حكينا إنه أنا
+
+1108
+01:45:18,100 --> 01:45:23,860
+المفروض أخد من الـ Ammoniac Fluid أفرض إن أنا جرحت
+
+1109
+01:45:23,860 --> 01:45:30,700
+الطفل وصار عنده نوع من النزف فنتيجة الأمر هذا راح
+
+1110
+01:45:30,700 --> 01:45:34,580
+يكون عندي الـ Alpha-Fetoprotein عالي Fetal Death
+
+1111
+01:45:34,580 --> 01:45:41,870
+إذا كان فيه Still Birth أو وفاة الحمل نفسهفي حالة
+
+1112
+01:45:41,870 --> 01:45:46,810
+الـ Twin Pregnancies إذا أنا مش منتبه وكان فيه
+
+1113
+01:45:46,810 --> 01:45:53,610
+حملة توقم وبالتالي كمية الحمل أكبر وبالتالي الـ
+
+1114
+01:45:53,610 --> 01:45:57,730
+Alpha-Fetoprotein ممكن يكون مستوقع أعلى Fetal
+
+1115
+01:45:57,730 --> 01:46:01,570
+Anomalies مثل هذه الأنواع برضه بترفعوا
+
+1116
+01:46:03,930 --> 01:46:08,910
+في أشياء دائما ممكن تكون مجهولة أو الـ
+
+1117
+01:46:08,910 --> 01:46:15,090
+«overestimation of gestational age» يعني شكله
+
+1118
+01:46:15,090 --> 01:46:22,070
+كل ما … يعني هنا إذا بنعتبره مرتفع فكان لأنه احنا
+
+1119
+01:46:22,070 --> 01:46:27,440
+هي مثلا أنا فكرت حامل بالشهر الثالثوهو أنا المفروض
+
+1120
+01:46:27,440 --> 01:46:32,740
+يكون بدأ ينزل الـ Alpha-Fetoprotein وانا بفكرها هي
+
+1121
+01:46:32,740 --> 01:46:38,960
+بالشهر مثلا السادس فهي حقيقة بالثالث وبعدها بكون
+
+1122
+01:46:38,960 --> 01:46:45,000
+أعلى طبيعي فممكن يكون بأنه أنا في كان خطأ في تقدير
+
+1123
+01:46:45,000 --> 01:46:52,720
+الحمل لما أخدناها وبالتالي يعني دائما صحيح أننا
+
+1124
+01:46:52,720 --> 01:46:56,480
+سوينا الـ procedureوعلى ضوءه، سأقول إن هذا مرتفع
+
+1125
+01:46:56,480 --> 01:47:00,220
+والله، يمكن الـ Neuronal Tube Defect «خلّيني أخلص
+
+1126
+01:47:00,220 --> 01:47:04,020
+منه» «ما بديش الحمل لأنه راح يغلب ويغلب وعنده
+
+1127
+01:47:04,020 --> 01:47:09,420
+المرض» وممكن يطلع إن هذا القراءة هي الغلط، مش أن
+
+1128
+01:47:09,420 --> 01:47:15,680
+الحالة فيها غلط فلما
+
+1129
+01:47:15,680 --> 01:47:20,340
+نعمل هنا، يعني النقطة التانية اللي بنتكلم عنهااللي
+
+1130
+01:47:20,340 --> 01:47:26,080
+هي أنه لما أخد من الـPlacenta أو الـCorionic villi
+
+1131
+01:47:26,080 --> 01:47:30,320
+Sampling باخد بيقوسين الـTertiary Corionic villi
+
+1132
+01:47:30,320 --> 01:47:37,600
+يعني بدي أخد جانب معين يعني اللي هنا هي الكيس
+
+1133
+01:47:37,600 --> 01:47:43,580
+الحمل هنا الجنين
+
+1134
+01:47:43,580 --> 01:47:51,660
+نفسه والطبقات تبعتهوبعدين هنا زي اللي بدّي أعمل
+
+1135
+01:47:51,660 --> 01:47:55,480
+الـPlacenta أو بدّي أعمل كده فبدأ أروح على مكان
+
+1136
+01:47:55,480 --> 01:48:00,640
+محدد عشان أاخد منه الـConnective tissues اللي
+
+1137
+01:48:00,640 --> 01:48:05,220
+بيفيها الـCells تبع الجنين والـBlood vessels وأعمل
+
+1138
+01:48:05,220 --> 01:48:16,460
+الفحص عليه بظل أنه لما يكون في عندنا Machine فيه
+
+1139
+01:48:16,460 --> 01:48:23,760
+Interactionبين الأم والجنين يعني دايماً في الولادة
+
+1140
+01:48:23,760 --> 01:48:27,920
+وخلال الحمل بيصير اختلاط بين خلايا الأم وبين خلايا
+
+1141
+01:48:27,920 --> 01:48:28,720
+الجنين
+
+1142
+01:48:31,480 --> 01:48:38,440
+حوالين الجنين، فيه الـ Cytotrophoplast وCyno نوع
+
+1143
+01:48:38,440 --> 01:48:42,080
+ثاني من الـ Trophoplast وفيه الـ Maternal blood و
+
+1144
+01:48:42,080 --> 01:48:46,360
+Maternal Sinusoid وفيه الـ Veins و الـ Capillaries
+
+1145
+01:48:46,360 --> 01:48:50,640
+و الـ Arteries تبع الجنين نفسه فكل دولة بيشتركوا
+
+1146
+01:48:50,640 --> 01:48:55,780
+مع بعض حتى ي support the patient أو ي support
+
+1147
+01:48:55,780 --> 01:49:00,320
+الجنين في الحالة
+
+1148
+01:49:00,320 --> 01:49:00,580
+هذه
+
+1149
+01:49:03,870 --> 01:49:08,090
+من الأشياء اللي بنقدر نعملها، فأحنا حكينا ممكن
+
+1150
+01:49:08,090 --> 01:49:12,770
+Ammoniotic Fluid Sampling ممكن Villus Sampling
+
+1151
+01:49:12,770 --> 01:49:19,190
+لأشياء أخرى ممكن في الـ «إن فيترو» أخد يعني سامبل
+
+1152
+01:49:19,190 --> 01:49:23,850
+من الـ«بلاستومير»
+
+1153
+01:49:23,850 --> 01:49:27,770
+قبل حتى من الأشياء المفيدة وكمان ممكن واحد يدور
+
+1154
+01:49:27,770 --> 01:49:31,730
+على أشياء معينة إذا كان واحد عنده خبرةاللي هو الـ
+
+1155
+01:49:31,730 --> 01:49:35,090
+Ultrasonography الـ Prenatal Diagnostic
+
+1156
+01:49:35,090 --> 01:49:39,810
+Ultrasonography الـ Sonar يعني عادةً بتعرفوا
+
+1157
+01:49:39,810 --> 01:49:43,730
+بيدوروا عادةً على الـ Heartbeat يشوف الـ إذا ذكروا
+
+1158
+01:49:43,730 --> 01:49:49,430
+الأنثى يشوف الـ External Genitalia بالنسبة للجنين،
+
+1159
+01:49:49,430 --> 01:49:53,710
+أشياء معينة فدولة يعني اللي هم العادي، الـ Sonar
+
+1160
+01:49:53,710 --> 01:49:58,670
+العادي اللي عادة الأطباء النسائي بيعملوه يعني
+
+1161
+01:49:58,670 --> 01:50:05,600
+بيدوروا واحدة أشياء معينةفيه بالنسبة لـ الـ يعني
+
+1162
+01:50:05,600 --> 01:50:08,880
+الـ other types of diseases that also can be
+
+1163
+01:50:08,880 --> 01:50:11,860
+diagnosed بس بيكون اللي بيعمل الـ sonar يعني
+
+1164
+01:50:11,860 --> 01:50:17,140
+experienced وبعرف على إيش بيدور وعن إيش بيدور وشو
+
+1165
+01:50:17,140 --> 01:50:21,680
+اللي بيدور عليه ففيه مرات single gene disorders
+
+1166
+01:50:21,680 --> 01:50:25,860
+دول الأسماء تبعتهم ممكن بالـ sonar يعني الـ
+
+1167
+01:50:25,860 --> 01:50:29,040
+infantile polycystic kidney diseaseاللي هو الـ
+
+1168
+01:50:29,040 --> 01:50:32,380
+Polycystic Kidney Disease أنا عادة بشوفهم لـ Adult
+
+1169
+01:50:32,380 --> 01:50:36,000
+Polycystic Kidney Disease بيكون بيبين بعدين ففيه
+
+1170
+01:50:36,000 --> 01:50:40,200
+Severe Form وبيكون بدخله Renal Failure وكذا وكذا
+
+1171
+01:50:40,200 --> 01:50:45,220
+من الولادة وفي فترة سريعة كثير وبيكون فيه Multiple
+
+1172
+01:50:45,220 --> 01:50:50,200
+Cysts على الـ Kidneys بتنشف في الجنين خلال الـ
+
+1173
+01:50:50,200 --> 01:50:55,660
+Ultrasonography حتى في الحمل Disorders هدولة أمثلة
+
+1174
+01:50:55,660 --> 01:50:58,740
+على Single Gene Disordersفيه كبار الـ Disorders
+
+1175
+01:50:58,740 --> 01:51:03,800
+مثلًا «مرتفاكتوريال» الـ «Cliff-lip»، «Club-foot»،
+
+1176
+01:51:03,800 --> 01:51:06,220
+«Congenital Heart Disease»، «Neuronal Tube
+
+1177
+01:51:06,220 --> 01:51:12,080
+Defect»، حكينا عنهم، هدولة كلهم موجودة وفي مرات
+
+1178
+01:51:12,080 --> 01:51:16,680
+إذا في أشياء معينة، ممكن تخليني أشكك سندروم معين،
+
+1179
+01:51:16,680 --> 01:51:21,080
+الـ «Abnormal Genitalia»، «Cystic Hagroma»، اللي
+
+1180
+01:51:21,080 --> 01:51:25,040
+هو يعني نوع من الأولمع الوجهة ضنني، ويكون له شكل
+
+1181
+01:51:25,040 --> 01:51:29,930
+معين،عدد الأصابع الـ Polydectomy وSyndectomy دي
+
+1182
+01:51:29,930 --> 01:51:33,570
+الأصابع ملتصقة ببعض طبعاً بدي يكون على مستوى معين
+
+1183
+01:51:33,570 --> 01:51:37,730
+تطور الجنين الـ Ophthalmalocele هذا اللي على
+
+1184
+01:51:37,730 --> 01:51:43,330
+بالبطن بيصير أنه يعني defect معين الـ Radial Ray
+
+1185
+01:51:43,330 --> 01:51:53,520
+Defect أشياء معينة فالـ هنا يعني الـ Sonographyفي
+
+1186
+01:51:53,520 --> 01:51:59,600
+مرات بتخليني أكتشف أشياء كثيرة وبرضه ممكن تعمل
+
+1187
+01:51:59,600 --> 01:52:05,260
+فإحنا يعني على قول اللي بيسأله هذا مطلوب ولا مش
+
+1188
+01:52:05,260 --> 01:52:14,100
+مطلوب، كأرقام وقداش النسب وكده وكده، لأ، ما بديش،
+
+1189
+01:52:14,100 --> 01:52:19,700
+بس الفكرة إنه الـ Sonography ممكن simple، non
+
+1190
+01:52:19,700 --> 01:52:25,930
+-invasiveeasy to do بس بيدها experience بيدها واحد
+
+1191
+01:52:25,930 --> 01:52:31,670
+فاهمان حتى يستثنى الموضوع يعني من القصص المشهورة
+
+1192
+01:52:31,670 --> 01:52:37,630
+جداً مثلا ييجوا عائلة يقولوا والله جابت خمس بنات
+
+1193
+01:52:37,630 --> 01:52:41,610
+وهسا الحملة السادس وييجوا واحد تبع Sonar مال
+
+1194
+01:52:41,610 --> 01:52:46,670
+بيفهمش ييجوا شاف وقال له هذا Female ممكن تطلع
+
+1195
+01:52:46,670 --> 01:52:50,560
+بالأخير Male يعني ممكن يكونبيطلع عنده بيطلع ولد
+
+1196
+01:52:50,560 --> 01:52:55,540
+يعني بالعكس يعني ففي مرات مشاكل إنه درجة خبرة
+
+1197
+01:52:55,540 --> 01:53:00,960
+الإنسان اللي بيقوم يعني الـ «الترساون» is as good
+
+1198
+01:53:00,960 --> 01:53:07,340
+as الـ person doing it حاطين بالكتاب بصراحة ما
+
+1199
+01:53:07,340 --> 01:53:11,460
+جبتهمش لإن أنا مش عارف أشرح عليهم بفهمش فيهم ومش
+
+1200
+01:53:11,460 --> 01:53:17,080
+تخصصي ومش خبير فيهم حاطين صور اللي هي أمثلة على
+
+1201
+01:53:17,080 --> 01:53:21,180
+الحالات هذهوكيف إنها بتبين بالـ Ultrasound وممكن
+
+1202
+01:53:21,180 --> 01:53:32,100
+شخصه من خلالها ففي عندنا قضية إنه كل ما بشوف مشاكل
+
+1203
+01:53:32,100 --> 01:53:38,160
+أكثر في الـ Ultrasound معناته الـ Abnormal
+
+1204
+01:53:38,160 --> 01:53:42,570
+Karyotype أو إن المشكلة أعقدالـ Karyotype نتذكر من
+
+1205
+01:53:42,570 --> 01:53:47,270
+الـ previous lectures لما نتكلم على huge area سواء
+
+1206
+01:53:47,270 --> 01:53:52,190
+chromosomal defect هذه بقدر أقصيدها بالـ Karyotype
+
+1207
+01:53:52,190 --> 01:53:57,470
+أو large chromosome segment سواء deletion،
+
+1208
+01:53:57,470 --> 01:54:02,870
+translocation، الـ other things فإيش يكون بالـ
+
+1209
+01:54:02,870 --> 01:54:08,320
+Abnormal Karyotype معناته huge problemفالفكرة اللي
+
+1210
+01:54:08,320 --> 01:54:12,620
+لما نكون الـ Karyotype Problem يعني أنا بحكي مرة
+
+1211
+01:54:12,620 --> 01:54:17,100
+ثانية كنا قضيني الـ Down Syndrome اللي هو خمس
+
+1212
+01:54:17,100 --> 01:54:22,240
+وثلاثين مظهر يعني مش بس العيون والإيدان والطول
+
+1213
+01:54:22,240 --> 01:54:25,320
+والـ Mental Retardation والـ Delayed Development
+
+1214
+01:54:25,320 --> 01:54:29,320
+والـ Heart Disease والـ Didoenal Atresiaوالكذا
+
+1215
+01:54:29,320 --> 01:54:33,780
+والكذا والكذا كله بتلاقي بتخربط أشياء كثيرة بالسبب
+
+1216
+01:54:33,780 --> 01:54:41,740
+إنه هاي عدد كبير من الجينات مش single gene فتطوير
+
+1217
+01:54:41,740 --> 01:54:47,960
+أكثر للـ Sonar وفي عندنا مثلا إذا حد منكم حتى
+
+1218
+01:54:47,960 --> 01:54:52,920
+بيقدر يتابع أو بعرف في دكتور عندنا اسمه خالد
+
+1219
+01:54:52,920 --> 01:54:57,420
+سالاينة Pediatric Cardologistالـ Pediatric
+
+1220
+01:54:57,420 --> 01:55:05,520
+Cardiologists اللي هما الـ الـ الـ
+
+1221
+01:55:05,520 --> 01:55:06,420
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1222
+01:55:06,420 --> 01:55:06,500
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1223
+01:55:06,500 --> 01:55:06,900
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1224
+01:55:06,900 --> 01:55:07,740
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1225
+01:55:07,740 --> 01:55:10,240
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1226
+01:55:10,240 --> 01:55:11,380
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1227
+01:55:11,380 --> 01:55:16,220
+الـ الـ
+
+1228
+01:55:16,220 --> 01:55:17,660
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1229
+01:55:22,580 --> 01:55:27,620
+إنه يصير إجهاض ويبدأ عملية إجهاض وكذا بس أحيانًا
+
+1230
+01:55:27,620 --> 01:55:31,160
+في مرحلة متأخرة من الحمل وإن ده الوضع كويس للأم
+
+1231
+01:55:31,160 --> 01:55:38,280
+وإشي simple و easy مش معقد ممكن يعني يعملوا عملية
+
+1232
+01:55:38,280 --> 01:55:44,140
+على الجنين technicalities بعرفهاش كتير فمن الأشياء
+
+1233
+01:55:44,140 --> 01:55:48,100
+اللي بتدرسنا الموضوع هذا إنه أنا أعمل fetal
+
+1234
+01:55:48,100 --> 01:55:53,990
+echocardiographyمن خلال الـ ECO اللي هو تبع فحص
+
+1235
+01:55:53,990 --> 01:56:00,910
+صدر القلب بنشوف الجنين وبنشوف
+
+1236
+01:56:00,910 --> 01:56:08,170
+شو المشكلة اللي عنده فهنا حاطيلكم بالأول نسب شو
+
+1237
+01:56:08,170 --> 01:56:11,150
+احتمالية إنه فيه congenital heart disease في اللي
+
+1238
+01:56:11,150 --> 01:56:16,110
+عنده هذا المرض هو هنا الـ Maternal Indicationsإذا
+
+1239
+01:56:16,110 --> 01:56:21,270
+الأم عندها type 1 diabetes mellitus اللي هو
+
+1240
+01:56:21,270 --> 01:56:24,470
+insulin dependent الـ congenital heart disease
+
+1241
+01:56:24,470 --> 01:56:32,150
+بالجنين 3% لـ 5% إذا بيكيو 15% Teratogen exposure
+
+1242
+01:56:32,150 --> 01:56:35,830
+نسبة أعلى الـ Thalidomide مشهور هذا، بتعرف قصته
+
+1243
+01:56:35,830 --> 01:56:42,270
+الـ Thalidomide دوة يعني بالخمسينات والستينات
+
+1244
+01:56:42,270 --> 01:56:50,800
+بالأولعبارة عن موضوع جيد جدًا لـ Nausea وأحيانًا
+
+1245
+01:56:50,800 --> 01:56:56,700
+بالذات مرضى السلطان أو مرضى أمراض كثيرة ممتاز جدًا
+
+1246
+01:56:56,700 --> 01:57:00,840
+جدًا جدًا من أحسن الحالات اللي ممتاز جدًا جدًا
+
+1247
+01:57:00,840 --> 01:57:07,080
+فيها التلوجاميد اللي هو الحمل فمعروف الحوامل
+
+1248
+01:57:07,080 --> 01:57:09,660
+يستفرغون
+
+1249
+01:57:12,820 --> 01:57:16,920
+الـ Hyperemesis Gravidarum بتسميه هذا من أحلى
+
+1250
+01:57:16,920 --> 01:57:21,480
+الأدوى وأحسن الأدوى له كان له شعبية كبيرة أمريكا
+
+1251
+01:57:21,480 --> 01:57:26,500
+رفضوا يدخلوه فانتشر كثير في أوروبا بعد انتشار هذا
+
+1252
+01:57:26,500 --> 01:57:34,460
+الدواء بسنين وأشهر لاقوا أنه كثير صار أطفال يطلعوا
+
+1253
+01:57:34,460 --> 01:57:41,580
+من غير إيدين ولا رجلين يعني كل اللمب طاير وثبت أنه
+
+1254
+01:57:41,580 --> 01:57:48,100
+من الثلاث دماغفالـ Thalidomide الآن للحوامل ممنوع
+
+1255
+01:57:48,100 --> 01:57:52,860
+خطر جدا ومع أنه يعني كان له شعبي بس لما ثبت أنه
+
+1256
+01:57:52,860 --> 01:57:59,060
+منه يعني بحتلوا الشركة وتغيرت أراء الأطباء وكذا
+
+1257
+01:57:59,630 --> 01:58:06,190
+فالـ Thalidomide نعرفه بطريقة معينة تقريباً مثلاً
+
+1258
+01:58:06,190 --> 01:58:10,650
+بس الـ Cancer أو الـ AIDS patient اللي بنعطيهم الـ
+
+1259
+01:58:10,650 --> 01:58:15,330
+Thalidomide لمن يكونوا مش كويسين يعني فالـ
+
+1260
+01:58:15,330 --> 01:58:19,490
+Thalidomide لدى Cancer exposure له نسبة الـ
+
+1261
+01:58:19,490 --> 01:58:23,290
+Congenital Heart Disease 10% الفيناتويل إذا كانت
+
+1262
+01:58:23,290 --> 01:58:29,010
+الأم تاخد Anti-epileptic الفيناتويل وجود الألكوهول
+
+1263
+01:58:29,740 --> 01:58:32,580
+الـ Maternal Congenital Heart Disease بزيد النسب
+
+1264
+01:58:32,580 --> 01:58:38,840
+هدولة يعني أمراض عند الأم المجموعة الثانية الـ
+
+1265
+01:58:38,840 --> 01:58:43,790
+Fetal Indicationsممكن الـ Abnormal Genital General
+
+1266
+01:58:43,790 --> 01:58:46,510
+Fetal Uterus Sound Examination Results أو إذا
+
+1267
+01:58:46,510 --> 01:58:49,570
+انتبهنا على الـ Arrhythmias لأنهم دائما يبحثون على
+
+1268
+01:58:49,570 --> 01:58:54,870
+أن القلب يبنبط بتحس أنه يبنبط الـ ECG ماعرفش إذا
+
+1269
+01:58:54,870 --> 01:59:02,530
+بتقدر، آه أظن بيحطوا الـ ECG للجنين وبيشوفوا الـ
+
+1270
+01:59:02,530 --> 01:59:05,690
+Arrhythmias تبعته إذا بنعرف إنه فيه Chromosomal
+
+1271
+01:59:05,690 --> 01:59:09,330
+Anomalies بالذات الـ Down Syndromeالـ Knuckle
+
+1272
+01:59:09,330 --> 01:59:13,770
+Thickening الـ Non-Immune Hydrophytalus إذا صار
+
+1273
+01:59:13,770 --> 01:59:19,190
+تكسر دم ممكن مع الـ Congenital Heart Disease أو
+
+1274
+01:59:19,190 --> 01:59:22,670
+إذا Family Syndrome زي الـ Mendelian Syndrome أو
+
+1275
+01:59:22,670 --> 01:59:25,850
+Paternal Congenital Heart Disease أو Privileged
+
+1276
+01:59:25,850 --> 01:59:33,530
+Child كل مرة بتزيد فأحياناًيعني هي اختلالات في
+
+1277
+01:59:33,530 --> 01:59:38,030
+الأم، اختلالات في نفس الجنين أو اختلالات في عائلة
+
+1278
+01:59:38,030 --> 01:59:43,590
+الأم والعائلة والأسرة هذه في العائلة تخلينا نروح
+
+1279
+01:59:43,590 --> 01:59:50,630
+ندور على Eco-cardiography على فحص صدر القلب للجنين
+
+1280
+01:59:50,630 --> 01:59:54,750
+الفكرة
+
+1281
+01:59:55,650 --> 02:00:01,890
+نرجح هنا، يمكن كان مفروض حطيناها جنب تبع الأسباب
+
+1282
+02:00:01,890 --> 02:00:07,730
+ليش الـ Alpha-Fetoprotein مرتفعة الإشكالية
+
+1283
+02:00:07,730 --> 02:00:11,950
+أنه حكينا
+
+1284
+02:00:11,950 --> 02:00:16,610
+أن أكثر شيء يرفعها الـ Spina Bifida اللي هو الـ
+
+1285
+02:00:16,610 --> 02:00:21,130
+Neuronal Tube Defect طبعاً هذه حالات نسأل الله
+
+1286
+02:00:21,130 --> 02:00:27,120
+سبحانه وتعالى أن يعافينا منهاومعتبروها congenital
+
+1287
+02:00:27,120 --> 02:00:32,020
+بس أكتر سبب له ومن اللي بيخففوا كثير الأسبانة بفدة
+
+1288
+02:00:32,020 --> 02:00:36,960
+اللي هو الـ Follet Replacement يعني عشان هيكي من
+
+1289
+02:00:36,960 --> 02:00:41,420
+الأشياء المهمة أنهالمجتمع أو الأطباء النسائية
+
+1290
+02:00:41,420 --> 02:00:46,520
+والحمل والمتابع هي أداة الحمل إنه يعطوا كل النساء
+
+1291
+02:00:46,520 --> 02:00:51,020
+الفولات ده لازم تكون تقضيتها كويسة لازم تأكل منه
+
+1292
+02:00:51,020 --> 02:00:55,120
+كويس بس لو في احتمال ما أكلتش أحسن نعطيها فولات
+
+1293
+02:00:55,120 --> 02:01:00,040
+فالفولات بيمنع الـ spinal بيفدى ويكون هذا المطلوب
+
+1294
+02:01:00,040 --> 02:01:06,020
+هنا بيعطيكم مثال إنه لو أنا جيتحطيت الـ Normal
+
+1295
+02:01:06,020 --> 02:01:11,800
+Distribution للـ Range of Normal Maternal Serum
+
+1296
+02:01:11,800 --> 02:01:15,980
+Alpha-Fetoprotein هنا طبعاً يعني مش تبع
+
+1297
+02:01:15,980 --> 02:01:19,000
+الأمانيوسينتيسيس اللي حكينا عنه
+
+1298
+02:01:22,150 --> 02:01:28,910
+بأخد دم الأم وبفحصها بالنسبة للـ Alpha-Feta
+
+1299
+02:01:28,910 --> 02:01:35,110
+Protein في الحمل بيزيد، بس إذا في حمل فيه Spinal
+
+1300
+02:01:35,110 --> 02:01:40,230
+Bifida فيه، النسبة أعلى بكتير وفي حالة الـ Down
+
+1301
+02:01:40,230 --> 02:01:45,400
+Syndrome، النسبة أقل بشكل ملحوظممكن ليس هناك فرق
+
+1302
+02:01:45,400 --> 02:01:51,000
+إحصائي بين الـ «أنا أفكتد» والـDown Syndrome بس
+
+1303
+02:01:51,000 --> 02:01:56,660
+الفكرة أنه كحالة بتسبب أنه فيه نقصان في الـ Alpha
+
+1304
+02:01:56,660 --> 02:02:00,280
+-Fetoprotein الـDown Syndrome والـSpina Fide بفي
+
+1305
+02:02:00,280 --> 02:02:04,480
+دا أقوى حالة أو Neuronal Tube Defect اللي بتعمل
+
+1306
+02:02:04,480 --> 02:02:09,680
+أنه الـAlpha-Fetoprotein عادي فهي شغل الواحد بنتبه
+
+1307
+02:02:09,680 --> 02:02:11,840
+لها الـ
+
+1308
+02:02:13,600 --> 02:02:22,520
+هذه حكينا عن أنه في أمراض كثيرة بالأم ماشي يعني
+
+1309
+02:02:22,520 --> 02:02:34,200
+هنا ناحية ثانية اللي هي أنه هنا
+
+1310
+02:02:34,200 --> 02:02:41,620
+أنه أنا بقدر أدرس أشياء معينة عن طريق فحص الأم
+
+1311
+02:02:41,620 --> 02:02:47,120
+نفسهاوبتكون أنه مثلًا أفحص الـ Alpha-Fetoprotein
+
+1312
+02:02:47,120 --> 02:02:53,120
+عند الأم بس بدي أتذكر أنه أنا أكبر مثل حكيته عن
+
+1313
+02:02:53,120 --> 02:02:58,540
+الـ Cause of Alpha-Fetoprotein increase اللي هو
+
+1314
+02:02:58,540 --> 02:03:04,040
+liver cancer و ال colon cancer بس هدولة بشكل عام
+
+1315
+02:03:04,040 --> 02:03:10,280
+اللي عندها سلطان ما بتحمله فيعني في الغالب ما بحط
+
+1316
+02:03:10,280 --> 02:03:16,740
+أناإن واحد عندها liver cancer أو colon cancer وحط
+
+1317
+02:03:16,740 --> 02:03:21,260
+إنه هذا من الـ cause of maternal serum alpha
+
+1318
+02:03:21,260 --> 02:03:25,080
+-fetoprotein concentration لأن هي ما راح تحمل
+
+1319
+02:03:25,080 --> 02:03:33,500
+بينما هنا حطين Antelope على أسباب أخرىفي الـ Skin،
+
+1320
+02:03:33,500 --> 02:03:37,500
+في الأم في الـ Spina Bifida؟ ماعرف إيش عاد قصده
+
+1321
+02:03:37,500 --> 02:03:40,380
+هنا، في الجنين ولا في الأم نفسها؟ إذا فيه
+
+1322
+02:03:40,380 --> 02:03:45,860
+Obstruction، إذا فيه Liver Damage؟ كل واحد، يعني،
+
+1323
+02:03:45,860 --> 02:03:52,080
+many types of diseases ممكن يخلي الـMaternal Alpha
+
+1324
+02:03:52,080 --> 02:03:54,340
+-Feta Protein الـConcentration high، بالتالي
+
+1325
+02:03:54,340 --> 02:03:57,600
+بتخليني أشك في إحدى من هذه الأشياء، وبالتالي
+
+1326
+02:03:57,600 --> 02:03:58,420
+أتعامل معها
+
+1327
+02:04:04,150 --> 02:04:13,850
+فالنقطة يعني الآن الخيارات اللي عندي إياها اللي هو
+
+1328
+02:04:13,850 --> 02:04:22,830
+يعني من خلال أنا اللي حكيته من أول إنه أنا عندي
+
+1329
+02:04:22,830 --> 02:04:27,810
+Ammoniac Fluid Sampling «قورينيك بيلاس» Sampling
+
+1330
+02:04:28,670 --> 02:04:36,230
+الـ In-vitro sampling والآن الـ Ultrasound هذه
+
+1331
+02:04:36,230 --> 02:04:40,310
+المثال الرابع اللي أنا حطينا أو جابوا مثاله على
+
+1332
+02:04:40,310 --> 02:04:46,650
+الـ Prenatal Screening الـ Ultrasound للحمل نفسه
+
+1333
+02:04:46,650 --> 02:04:52,570
+والنقطة اللي أضفناها قضية إن أنا ممكن أسحب دم من
+
+1334
+02:04:52,570 --> 02:04:59,990
+الأم ونتيجة اختلاط سواء الـ DNA لوحدهمن الجنين أو
+
+1335
+02:04:59,990 --> 02:05:04,830
+من خلايا الجنين مع الخلايا الأم إنه في الدم ممكن
+
+1336
+02:05:04,830 --> 02:05:10,110
+أنا ألاقي مؤشرات على abnormalities معينة ممكن
+
+1337
+02:05:10,110 --> 02:05:13,970
+تفيدني مثل Alpha-Fetoprotein فهنا حلاوة الـ
+
+1338
+02:05:13,970 --> 02:05:17,910
+Maternal Serumمثلًا، تجارب بشكل بسيط، بسهولة،
+
+1339
+02:05:17,910 --> 02:05:23,050
+وليست مهيجة للجنين، ولا تحصل على إحتماليات مثل الـ
+
+1340
+02:05:23,050 --> 02:05:27,210
+Amniotic وCorionic Blood Sampling لتعمل الـ
+
+1341
+02:05:27,210 --> 02:05:35,070
+Damage، فهذا يكون أسهل، لكن هذه النوع من التجارب
+
+1342
+02:05:35,290 --> 02:05:39,090
+فيه له محاضير كثيرة ومرات ما بستفيدش منها في أشياء
+
+1343
+02:05:39,090 --> 02:05:42,630
+كثيرة فالـ Alpha-Fetoprotein Concentration هذا الـ
+
+1344
+02:05:42,630 --> 02:05:47,170
+Maternal ممتاز وسهل وبسيط وممكن يصيدي أشياء كثيرة
+
+1345
+02:05:47,170 --> 02:05:51,290
+من
+
+1346
+02:05:51,290 --> 02:05:59,410
+الأشياء الثانية اللي بنعملها اللي هي أنه ممكن
+
+1347
+02:05:59,410 --> 02:06:04,350
+أنا الـ Alpha-Fetoprotein نقول اللي ذكرناهافي عندي
+
+1348
+02:06:04,350 --> 02:06:08,030
+الـ HCG اللي هو الـ Human Coronary Gonadotrophin
+
+1349
+02:06:08,030 --> 02:06:17,330
+تبع الحمل كهرمون وفيه إشي اسمه N-HPNA وفيه other
+
+1350
+02:06:17,330 --> 02:06:24,850
+يعني parameters زي ارتخائر الرقبة أو Nuclear
+
+1351
+02:06:24,850 --> 02:06:32,580
+Translucency وفيه إشي اسمه اللي هوHuman Corionic
+
+1352
+02:06:32,580 --> 02:06:36,360
+Gonadotropin Beta-subunit أو الـ Pregnancy Assured
+
+1353
+02:06:36,360 --> 02:06:40,960
+Plasma Protein A بي إيه بي إيه بي إيه بي إيه بي
+
+1354
+02:06:40,960 --> 02:06:45,240
+إيه بي إيه بالشكل هذا أو بي إيه بي إيه بي إيه هذا
+
+1355
+02:06:45,240 --> 02:06:56,880
+الفكرة أنه يعني هذه الأشياء هنا بفحصها هنا هي بالـ
+
+1356
+02:06:56,880 --> 02:07:02,980
+ultrasoundوهدولة عن طريق الـ Maternal Serum يعني
+
+1357
+02:07:02,980 --> 02:07:07,440
+بسحب الـ Serum تبعتها وهنا بحكي لكم أن أحياناً أنا
+
+1358
+02:07:07,440 --> 02:07:12,680
+ممكن أشخص أشياء كثيرة إذا بشوف Anomalies بشكل
+
+1359
+02:07:12,680 --> 02:07:18,660
+معين، ماشي؟ فالـ Trisomy 121 Down Syndrome أو أكثر
+
+1360
+02:07:18,660 --> 02:07:23,920
+واحد، بس ممكن 18 و 13، نسبهم أقل وإذا فيه Neuronal
+
+1361
+02:07:23,920 --> 02:07:28,410
+Tube Defect برضه سيءالنيرونال بالنسبة لنا بيفدى
+
+1362
+02:07:28,410 --> 02:07:33,590
+الطفل بيطلع طبيعي من فوق يعني paraplegia يعني شلل
+
+1363
+02:07:33,590 --> 02:07:39,070
+بالنصف السفلي بس مرات الـ Neuronal Cube Defect إذا
+
+1364
+02:07:39,070 --> 02:07:42,590
+من جهة اللي فوق أنا انكفلي و أشياء ثانية ممكن تكون
+
+1365
+02:07:42,590 --> 02:07:47,330
+Very Very Severe فهنا هاي إذا عائلة في عندها مشكلة
+
+1366
+02:07:47,330 --> 02:07:56,850
+ممكن شو اسمها؟أفحص هذه الأشياء وهنا بأفحصها بالـ
+
+1367
+02:07:56,850 --> 02:08:01,550
+First Trimester ثلث الأول للحمل، من تسعة شهور وأو
+
+1368
+02:08:01,550 --> 02:08:05,790
+الثلث الثاني بلاقي إن بقدر أفحص على أشياء ثانية
+
+1369
+02:08:05,790 --> 02:08:10,410
+وبقدر من خلالهم أشخص أشياء معينة الـ Alpha-Beta
+
+1370
+02:08:10,410 --> 02:08:13,490
+-Protein أهم واحد وهذا اللي بديها وبيكون مع الـ
+
+1371
+02:08:13,490 --> 02:08:19,090
+Neuronal Tube Defect البقية، يعني تفاصيلها، يعني
+
+1372
+02:08:19,090 --> 02:08:22,970
+حاطين إشي برتفع، إشي بنزلفهذه بدأت تكون لـ
+
+1373
+02:08:22,970 --> 02:08:28,630
+Pediatrician أو Gynecologist أوبستاتريشن تبع طبيب
+
+1374
+02:08:28,630 --> 02:08:32,970
+حوامل إذا كان أثير موضوع إنه فيه كان طفل أول عنده
+
+1375
+02:08:32,970 --> 02:08:40,430
+مشكلة والآن بقالنا طفل ثاني من الأشياء المهمة اللي
+
+1376
+02:08:40,430 --> 02:08:49,830
+هي موضوع إنه الإنسان بنسميه Mosaic الفكرة
+
+1377
+02:08:49,830 --> 02:08:58,240
+إنهالإنسان لما يكون في البطل أمه في الحمل بيكون
+
+1378
+02:08:58,240 --> 02:09:06,900
+يعني الانسان هو في مجال اختلاط الخلايا بين الأم
+
+1379
+02:09:06,900 --> 02:09:13,800
+وبين الجنين فبالـ Peripheral blood للأم بيكون بعض
+
+1380
+02:09:13,800 --> 02:09:21,140
+الخلايا أجت من الجنين فبالتالي هنا حاطينأسلوب معين
+
+1381
+02:09:21,140 --> 02:09:26,400
+للدراسة اللي هو «Non-invasive prenatal screening»
+
+1382
+02:09:26,400 --> 02:09:33,920
+نسميه «NIPS» «Non-invasive prenatal screening» هنا
+
+1383
+02:09:33,920 --> 02:09:38,220
+إذا الواحد عنده جهاز قادر على أن يعمل هذا الأشي
+
+1384
+02:09:38,220 --> 02:09:47,680
+اللي راح يسوي إنه راح يسحب دم الأنثى بـ
+
+1385
+02:09:47,680 --> 02:09:53,710
+«peripheral blood»بعرفش هو من الـ Serum بيعملوا
+
+1386
+02:09:53,710 --> 02:09:57,970
+License للـ Cells كلها وبعدين بياخدوها كلها المهم
+
+1387
+02:09:57,970 --> 02:10:03,030
+بيعزلوا الـ DNA تبع كل الأشياء اللي موجودة في الـ
+
+1388
+02:10:03,030 --> 02:10:07,610
+Serum بالـ Maternal Serum فـ Cell-free DNA الـ
+
+1389
+02:10:07,610 --> 02:10:14,650
+Maternal Serum هذا الغالبية العظمى جدا منه من الأم
+
+1390
+02:10:14,650 --> 02:10:24,600
+بس بيظل الإنسان في عنده شوية DNAمن الـ Fetus يعني
+
+1391
+02:10:24,600 --> 02:10:32,960
+فيه يعني هذا مصطلح نستخدمه حتى في المناعة نسميه
+
+1392
+02:10:32,960 --> 02:10:40,560
+لأن الإنسان is a chimera chimera هو مخلوق يعني
+
+1393
+02:10:40,560 --> 02:10:46,580
+خيالي بالأساطير الرومانية واليونانية إنه شخصين في
+
+1394
+02:10:46,580 --> 02:10:51,880
+جسم واحدمرات بالرسوم المتحركة فيجيبولك راسين في
+
+1395
+02:10:51,880 --> 02:10:57,580
+جسم واحد أو شخصين أو اثنين ملتصقين زي توائم سيامية
+
+1396
+02:10:57,580 --> 02:11:03,680
+أو الكايميرة نفسها راس إنسان أو راس أسد جسم أسد
+
+1397
+02:11:03,680 --> 02:11:08,680
+وراس إنسان ودال حي وإجران فيل وخرطوم مش عارف إيش
+
+1398
+02:11:08,680 --> 02:11:13,620
+زي الحي يعني أنه من أكثر من جزء فهنا اللي بيسووا
+
+1399
+02:11:13,620 --> 02:11:21,680
+أنه بعزلوا الـ DNAالـ Free في الـ Serum تبع الأم
+
+1400
+02:11:21,680 --> 02:11:29,020
+فشغلة صحبة دم بسيطة باجي بعمل اللي هو NGS اللي هو
+
+1401
+02:11:29,020 --> 02:11:37,880
+الـ Next Generation Sequencing للواحد يعرف شو
+
+1402
+02:11:37,880 --> 02:11:43,420
+الأسماء مرات معقد الشغلفهي يعني جهاز Sequencer
+
+1403
+02:11:43,420 --> 02:11:47,620
+يعني بيقرأ الـ«نيكلوتايدز» بشكل سريع جداً جداً
+
+1404
+02:11:47,620 --> 02:11:53,480
+يعني فاق السرعة بكمبيوتر سريع جداً الفكرة أنه لما
+
+1405
+02:11:53,480 --> 02:12:01,460
+نقرأ القطع هذه ونكون عارفين عنها بالأخير نقدر نعدد
+
+1406
+02:12:01,460 --> 02:12:05,300
+شو هي الـCopies ومن أنه كرمزوم هذه القطعة اللي
+
+1407
+02:12:05,300 --> 02:12:09,680
+قرناهافهي يعني نوع من زي الـ Human Genome Project
+
+1408
+02:12:09,680 --> 02:12:15,360
+بس سريع جدًا جدًا وبسرعة الاهتمام هنا في المثال
+
+1409
+02:12:15,360 --> 02:12:22,800
+هذا إنه أشوف كام copy من أي chromosome أنا بتكلم
+
+1410
+02:12:22,800 --> 02:12:26,720
+عنه فالأصل ألاقي two chromosome ones، two
+
+1411
+02:12:26,720 --> 02:12:29,960
+chromosomes two، كذا كذا إذا لقيت three
+
+1412
+02:12:29,960 --> 02:12:35,040
+chromosomes twenty-two ممكن أقول إنه عدد ال copies
+
+1413
+02:12:35,040 --> 02:12:40,550
+هنا أكتر أوفي Unplied أو Uplied أو Duplied إذا في
+
+1414
+02:12:40,550 --> 02:12:44,870
+سواء لـ One Chromosome أو كل الكرمزومات أو Half
+
+1415
+02:12:44,870 --> 02:12:49,010
+Chromosomes يعني هل في One-End، Two-End، Three
+
+1416
+02:12:49,010 --> 02:12:55,250
+-End، Four-End، Six-End أو كده فالفكرة
+
+1417
+02:12:55,250 --> 02:13:03,730
+الآن هو المثال اللي حطيناه هنا يعني اللي بدل واحد
+
+1418
+02:13:03,730 --> 02:13:08,670
+ينتبهله أنهفي أشياء يمكن يفضل تنعمل بالـ First
+
+1419
+02:13:08,670 --> 02:13:15,770
+Trimester بس في أشياء ممكن نصير أه و الله نقدر
+
+1420
+02:13:15,770 --> 02:13:20,130
+نستفيد منها أكتر لما نعملها بالثلاث شهور التاني
+
+1421
+02:13:20,130 --> 02:13:25,070
+بين الشهر الرابع للسادس فإنه أنا بسوي المتابعة على
+
+1422
+02:13:25,070 --> 02:13:29,330
+أكتر من شهر وعلى أكتر من محل أني أدور على أي شيء
+
+1423
+02:13:29,330 --> 02:13:34,590
+معينفهنا الـ Chimerism
+
+1424
+02:13:34,590 --> 02:13:40,610
+أو الـ Mosaicism إنه الـ DNA من أكتر من مصدر وأنا
+
+1425
+02:13:40,610 --> 02:13:48,850
+بروح بشوف خواص الـ DNA تبع الجنين وبحكم من خلاله
+
+1426
+02:13:48,850 --> 02:13:52,990
+على إنه فيه مشكلة في الجنين وممكن أشخص أسريع معينة
+
+1427
+02:13:53,610 --> 02:13:57,690
+في مقابل إن هذا فحص بسيط وسهول ومن الأم بسحب نتفة
+
+1428
+02:13:57,690 --> 02:14:03,690
+الدم وبعطيه مؤشر شهو الجنين عنده وهذا بستخدم فيه
+
+1429
+02:14:03,690 --> 02:14:09,310
+NIPS وبستخدم فيه NGS Next Generation Sequencing
+
+1430
+02:14:09,310 --> 02:14:18,510
+فحتى الفكرة لما على الأقل هذا من خلال دراسة معينة
+
+1431
+02:14:18,510 --> 02:14:22,950
+طلعت سنة 2014الـ New England Journal of Medicine
+
+1432
+02:14:22,950 --> 02:14:30,510
+إنه الـ First Trimester Triple Screen اللي حكينا
+
+1433
+02:14:30,510 --> 02:14:36,130
+عنه هنا الـ Nucleotide Transducency و الـ BPA و
+
+1434
+02:14:36,130 --> 02:14:43,830
+الـ Free Beta-HCG و لا كذاالـ Sensitivity 85% والـ
+
+1435
+02:14:43,830 --> 02:14:50,030
+False Positive Rate 5% أحنا بيهمنا كل ما يكون هذا
+
+1436
+02:14:50,030 --> 02:14:56,190
+Sensitivity أكثر وSpecificity أقل Sensitivity إن
+
+1437
+02:14:56,190 --> 02:15:00,050
+المرض اللي عنده مرض نطلع إنه فعلا مريض
+
+1438
+02:15:00,050 --> 02:15:05,250
+وSpecificity إنه سليم نطلع إنه سليم يعني هنا
+
+1439
+02:15:05,250 --> 02:15:10,300
+الافتلاق بينهمهم عادةً العلاقة بينهم عكسية كل ما
+
+1440
+02:15:10,300 --> 02:15:13,620
+بدأ أزود الـ sensitivity بقلل الـ specificity هيك
+
+1441
+02:15:13,620 --> 02:15:18,620
+العلاقة على نفس الـ test الواحد في الحالة الواحدة
+
+1442
+02:15:18,620 --> 02:15:22,480
+أما لما يكون عندي أكتر من إيشي وأسوي أشياء مختلفة
+
+1443
+02:15:22,480 --> 02:15:27,120
+الـ non-invasive prenatal screening كله لما نعمله
+
+1444
+02:15:27,120 --> 02:15:33,820
+بالكاملأكتر من 99% sensitivity وأقل من 1%
+
+1445
+02:15:33,820 --> 02:15:43,120
+specificity بس هاد برضه أرقام مهمة فالفكرة أنه الـ
+
+1446
+02:15:43,120 --> 02:15:50,040
+Non-invasive Screening
+
+1447
+02:15:50,040 --> 02:15:57,420
+الأصل يكون هو الأول وأنا يعني ممكن كـConsultant
+
+1448
+02:15:58,030 --> 02:16:01,970
+ويجيني عائلة عندهم مشكلة أو عندهم حالة بدهم يسوي
+
+1449
+02:16:01,970 --> 02:16:07,770
+دراسة عليها الأصل أنه بالأول أبدأ أو يكون عندي خطة
+
+1450
+02:16:07,770 --> 02:16:12,850
+الطريق، خارطة الطريق، «شو بدي أعمل؟» بالترتيب، في
+
+1451
+02:16:12,850 --> 02:16:18,710
+كل حالة فعادة أو الأصل أو الأحسن أنه أبدأ بإنه
+
+1452
+02:16:18,710 --> 02:16:23,290
+أعمل «Non-invasive Screening» في الـ«أول عام» وفي
+
+1453
+02:16:23,290 --> 02:16:27,650
+«الثانوية عامة» وفي مش عارف إيش وكدهطبعاً حتى في
+
+1454
+02:16:27,650 --> 02:16:31,790
+الـ first trimester أو في مرحلة مبكرة ممكن أحتاج
+
+1455
+02:16:31,790 --> 02:16:36,230
+أحياناً كوريانيك بيللسامبلينج أو menu synthesis أو
+
+1456
+02:16:36,230 --> 02:16:40,850
+الـ invasive testing وممكن أني أصل في مرحلة أن
+
+1457
+02:16:40,850 --> 02:16:44,450
+أقول لأ والله الفحص negative والأمور إن شاء الله
+
+1458
+02:16:44,450 --> 02:16:48,350
+سليمة وأقولهم مافي داعي تخلقوا إن شاء الله الأمور
+
+1459
+02:16:48,350 --> 02:16:53,350
+كويسة وknow that the testing is neededمش ممكن
+
+1460
+02:16:53,350 --> 02:16:59,030
+نعمله أو لأنه خلاص النتيجة طلعت إيجابية فهي النقطة
+
+1461
+02:16:59,030 --> 02:17:09,470
+يعني كملخص للفصل هذا إنه إحنا لما نتعامل مع
+
+1462
+02:17:09,470 --> 02:17:18,900
+الأمراض الوراثية في عندنا جوانب بالأول بنسويهافي
+
+1463
+02:17:18,900 --> 02:17:27,100
+ما قبل الزواج أحيانًا أحيانًا يعني عند الولادة
+
+1464
+02:17:27,100 --> 02:17:31,060
+المفروض يكون فيه نوع من الـ Screening ويكون للطفل
+
+1465
+02:17:31,060 --> 02:17:36,280
+سليم وولادة طبيعية برضه بعمل بعض الفحوصات عشان
+
+1466
+02:17:36,280 --> 02:17:41,840
+أستثنى بعض الأمراض هدولة ممكن سهلات وخفيفات وعادة
+
+1467
+02:17:41,840 --> 02:17:46,280
+Simple بس في حاجة وهدولة في الغالب يعني بنسميها
+
+1468
+02:17:46,280 --> 02:17:51,530
+Screen لـGeneral Populationللأموم الناس أما لما
+
+1469
+02:17:51,530 --> 02:17:56,370
+يصير عندى حالة أنه عائلة عندهم مشكلة وأنا كـ
+
+1470
+02:17:56,370 --> 02:18:01,830
+consultant وكذا وبيهمني أني أتأكد كيف أتعامل مع
+
+1471
+02:18:01,830 --> 02:18:05,310
+هذا الموضوع وكل اللي بنحكي عنه invasive و non
+
+1472
+02:18:05,310 --> 02:18:10,570
+-invasive وscreening وكذا وكذا في حالة إذا فكرة
+
+1473
+02:18:10,570 --> 02:18:15,560
+أنه يكون فيه abortionأو نوع من الـ Abortion مقبول
+
+1474
+02:18:15,560 --> 02:18:19,740
+أو في حالة إن والله عندي إمكانيات أعمل والله رأيت
+
+1475
+02:18:19,740 --> 02:18:22,840
+الـ Congenital Heart Disease أعمل جراحة للجنين في
+
+1476
+02:18:22,840 --> 02:18:29,320
+بطنه فهذه يعني النقاط فالمطلوب، المطلوب
+
+1477
+02:18:29,320 --> 02:18:35,740
+للـConsultant أنه يكون عنده خارطة طريقة بهذا
+
+1478
+02:18:35,740 --> 02:18:40,870
+المثال، بهذه الطريقة يكون منتبهطبعًا يعني الـ
+
+1479
+02:18:40,870 --> 02:18:43,310
+«سلايد» اللي قبل شوية «الخاصية» «الخاصية»
+
+1480
+02:18:43,310 --> 02:18:43,870
+«الخاصية» «الخاصية» «الخاصية» «الخاصية» «الخاصية»
+
+1481
+02:18:43,870 --> 02:18:44,630
+«الخاصية» «الخاصية» «الخاصية» «الخاصية» «الخاصية»
+
+1482
+02:18:44,630 --> 02:18:45,090
+«الخاصية» «الخاصية» «الخاصية» «الخاصية» «الخاصية»
+
+1483
+02:18:45,090 --> 02:18:45,510
+«الخاصية» «الخاصية» «الخاصية» «الخاصية» «الخاصية»
+
+1484
+02:18:45,510 --> 02:18:46,910
+«الخاصية» «الخاصية» «الخاصية» «الخاصية» «الخاصية»
+
+1485
+02:18:46,910 --> 02:18:49,170
+«الخاصية» «الخاصية» «الخاصية» «الخاصية» «الخاصية»
+
+1486
+02:18:49,170 --> 02:18:56,950
+«الخاصية»
+
+1487
+02:18:56,950 --> 02:19:01,330
+«الخاصية
+
+1488
+02:19:01,680 --> 02:19:09,460
+والـ True Negative لأنه يقدر يقود الأهل في هذه
+
+1489
+02:19:09,460 --> 02:19:16,140
+النقاط من خلال كل الخيارات المتاحة سواء كـ
+
+1490
+02:19:16,140 --> 02:19:21,560
+Screening و Testing وبعد ذلك كعلاج فأظن هذا آخر
+
+1491
+02:19:21,560 --> 02:19:27,000
+Slide أو لأ، في واحد الـ Mosaicism يعني اللي هو
+
+1492
+02:19:27,000 --> 02:19:33,260
+أنه أحيانًافي نفس الطريق، يعني خلال نفس الحمل في
+
+1493
+02:19:33,260 --> 02:19:39,760
+مرحلة معينة ممكن تصير بعض الـ… الـMutations أو
+
+1494
+02:19:39,760 --> 02:19:50,240
+اختلالات بشكل معين يعني أنه يكون يعني فيه اختلالات
+
+1495
+02:19:50,240 --> 02:19:58,700
+بشكل يعني هنا، يعني أخذوا مثل الـDeployedاللي هو
+
+1496
+02:19:58,700 --> 02:20:03,960
+الإنسان الطبيعي خلايا تبعات الإنسان الطبيعي خلايا
+
+1497
+02:20:03,960 --> 02:20:07,220
+الـDeploid إلا في الـOverheads والـSperms
+
+1498
+02:20:07,220 --> 02:20:11,800
+الـAneuploid يعني اللي هي مش طبيعية باختلال بشكل
+
+1499
+02:20:11,800 --> 02:20:19,440
+معين 3N، 4N أو 1N مثلا أو الـTrisomy، إشي زي هيك
+
+1500
+02:20:19,440 --> 02:20:27,100
+فلمّا مرات في الغالب هذه بتكون حادثةتحدث في بعض
+
+1501
+02:20:27,100 --> 02:20:31,180
+الخلايا في مرحلة مبكرة فهو أنا هأعطيكم المثال إنه
+
+1502
+02:20:31,180 --> 02:20:37,340
+هي في مرحلة الـ Plastomere وصار بعض الخلايا يعني
+
+1503
+02:20:37,340 --> 02:20:41,160
+صار فيها طفرة صارت خطرة بدل ما هي حمرا والحمرة هو
+
+1504
+02:20:41,160 --> 02:20:50,380
+الطبيعي فالخيارات متعددةفهنا لما أخذ خلية مثل ما
+
+1505
+02:20:50,380 --> 02:20:54,600
+حكينا تبعها الـ IVF وأدرسها فيه احتمال أن أخذ
+
+1506
+02:20:54,600 --> 02:20:58,720
+الخلية الطبيعية ويكون فيها خلايا مصابة موجودة أو
+
+1507
+02:20:58,720 --> 02:21:01,720
+بالعكس، أخذ خلية مصابة وغالبين باقية الخلايات
+
+1508
+02:21:01,720 --> 02:21:08,220
+خلايا طبيعية، فهذا احتمال، وبدأ أنتبه أنه أنا في
+
+1509
+02:21:08,220 --> 02:21:12,020
+مرات، يعني عندي أربع احتمالات أنا أحس أن عندي
+
+1510
+02:21:12,020 --> 02:21:17,710
+نوعين من الخلايافي الممكن إنه يكون طبعاً أنا لما
+
+1511
+02:21:17,710 --> 02:21:21,670
+أعمل Corionic Pillar Sampling باخد من خلايا هذا
+
+1512
+02:21:21,670 --> 02:21:27,210
+الجزء، ماشي على أساس إنه يكون معبر عن الطفل بس
+
+1513
+02:21:27,210 --> 02:21:32,410
+ممكن في المرحلة الـA إنه يكون تماماً معبر عن حالة
+
+1514
+02:21:32,410 --> 02:21:37,390
+الطفل إنه بلاقي الخلايا الـAbnormal وبلاقي الخلايا
+
+1515
+02:21:37,390 --> 02:21:41,090
+الـNormal وإنه فعلاً الجنين نفسه عنده الـNormal
+
+1516
+02:21:41,090 --> 02:21:46,420
+والـAbnormalبالإحتمال بيه أنا والله أخدت من الـ
+
+1517
+02:21:46,420 --> 02:21:50,620
+Corionic Pillus ولقيت فيه خلايا Abnormal بس
+
+1518
+02:21:50,620 --> 02:21:55,640
+بالصدفة يعني هو أنا لقيت الـNormal والـAbnormal
+
+1519
+02:21:55,640 --> 02:22:00,380
+والجنين كان Completely Normal فهاجي ويجي واحد يعمل
+
+1520
+02:22:00,380 --> 02:22:03,820
+الفحص ويلاقي خلايا Abnormal ينصح الأهل والله
+
+1521
+02:22:03,820 --> 02:22:06,900
+اعملوا إجهاض ويطلع الجنين كله Normal هذا احتمال
+
+1522
+02:22:06,900 --> 02:22:12,330
+وادي، يكون هنا mixtureالاحتمال ثالث كمان وارد أنه
+
+1523
+02:22:12,330 --> 02:22:17,070
+هذه الخلايا الـ Abnormal بس بالـ Placenta مش في
+
+1524
+02:22:17,070 --> 02:22:21,870
+الجنين نفسه، برضه هي راح تعمل مشكلة وبالعكس، في
+
+1525
+02:22:21,870 --> 02:22:27,990
+مرات أنه أنا بعمل الـ Velas Sample وبيطلع عندي
+
+1526
+02:22:27,990 --> 02:22:31,830
+Completely Normal بس نفس الجنين مصاب وانا ماكنتش
+
+1527
+02:22:31,830 --> 02:22:36,490
+عارف، مافادنيش كتير، غشن الفحص فكل هذه احتمالات
+
+1528
+02:22:36,490 --> 02:22:41,230
+واردة وبدأت تكون بالباللما واحد يقرر إنه أنا ضروري
+
+1529
+02:22:41,230 --> 02:22:44,050
+أعمل هذا الفحص، بقدر أعمل هذا، طبعاً من الأول بقدر
+
+1530
+02:22:44,050 --> 02:22:47,490
+أعمله، ده بحاجته، لأنه فيه مرات كتيرة في الناس أو
+
+1531
+02:22:47,490 --> 02:22:51,210
+أماكن في العالم، مافي مجال أن يعمل هذه الفحصات،
+
+1532
+02:22:51,210 --> 02:22:57,310
+ماشي؟ وبعدين، بدي الواحد يظل منفتح على إنه ممكن
+
+1533
+02:22:57,310 --> 02:23:02,150
+الفحص يكون يخدع ومش ممثل حقيقي عن شو هو وضع الجنين
+
+1534
+02:23:03,030 --> 02:23:07,530
+فهيك بنكون خلصنا محاضرتين تبعات الأسبوع هذا والله
+
+1535
+02:23:07,530 --> 02:23:13,030
+يعطيكم العافية وإذا في أسئلة يعني حد يتكلم أو
+
+1536
+02:23:13,030 --> 02:23:19,410
+نخليها لبداية الأسبوع الجاي وبعدين بالنسبة لـفي
+
+1537
+02:23:19,410 --> 02:23:23,050
+الـ «جروب» تبعت الـ «جروب» للـ «جالتكس» الـ
+
+1538
+02:23:23,050 --> 02:23:24,550
+«جالتكس» الـ «جالتكس» الـ «جالتكس» الـ «جالتكس»
+
+1539
+02:23:24,550 --> 02:23:29,230
+الـ «جالتكس» الـ «جالتكس» الـ
+
+1540
+02:23:29,230 --> 02:23:30,310
+«جالتكس» الـ «جالتكس» الـ «جالتكس» الـ «جالتكس»
+
+1541
+02:23:30,310 --> 02:23:32,610
+«جالتكس» الـ «جالتكس» الـ «جالتكس» الـ «جالتكس»
+
+1542
+02:23:32,610 --> 02:23:35,730
+الـ «جالتكس» الـ «جالتكس» الـ «جالتكس» الـ
+
+1543
+02:23:35,730 --> 02:23:43,150
+«جالتكس» الـ
+
+1544
+02:23:43,150 --> 02:23:46,110
+«جالتكس
+
+1545
+02:23:46,160 --> 02:23:49,400
+الله يعافيكم ويرضى عليكم إن شاء الله تكون الأمور
+
+1546
+02:23:49,400 --> 02:23:55,700
+واضحة وتكون مستفيدين إن شاء الله الله حيكم أهلا و
+
+1547
+02:23:55,700 --> 02:23:58,220
+أهلا نشوفكم الأسبوع الجاية إن شاء الله
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ecLGirzn8pc_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ecLGirzn8pc_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..8821220c4ed921cac57eec1922fb71158e373312
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ecLGirzn8pc_raw.json
@@ -0,0 +1 @@
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Thyroid Disease الـ PQ، برضه بنعمله، دخلناها، والفكرة فيه إنه إذا أكل لوغ", "tokens": [6027, 20292, 8032, 2304, 2423, 39184, 47560, 270, 1434, 34051, 2423, 39184, 45649, 18907, 6490, 1434, 8717, 5172, 5016, 9381, 2423, 39184, 314, 17308, 4724, 40448, 25724, 1863, 9957, 46599, 6027, 2655, 6027, 1829, 44945, 28543, 2288, 8717, 3615, 28480, 11933, 15730, 43242, 3224, 8717, 3615, 9566, 1829, 11296, 2423, 39184, 40010, 340, 87, 533, 13412, 17082, 1211, 21532, 12399, 16002, 12399, 9154, 6055, 1863, 4587, 11242, 3224, 9154, 3714, 43042, 8608, 1829, 38207, 10874, 28259, 14111, 12399, 3714, 33599, 1829, 22807, 2423, 39184, 40010, 6490, 35360, 2423, 39184, 430, 48, 12399, 4724, 43042, 3224, 44945, 25957, 43761, 12399, 11778, 9778, 1211, 8315, 11296, 12399, 16070, 5172, 4117, 25720, 8978, 3224, 36145, 3224, 11933, 15730, 5551, 28820, 45164, 17082], "avg_logprob": -0.2248697865754366, "compression_ratio": 1.5137254901960784, "no_speech_prob": 1.5497207641601562e-06, "words": [{"start": 5346.35, 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مثلا السادس فهي حقيقة بالثالث وبعدها بكون أعلى طبيعي فممكن يكون بأنه أنا في كان خطأ في تقدير الحمل لما أخدناها وبالتالي يعني دائما صحيح أننا سوينا الـ procedure", "tokens": [2407, 3224, 2407, 41850, 9673, 5172, 32887, 11242, 7251, 30544, 47525, 10721, 7251, 1863, 11622, 1211, 2423, 39184, 20588, 12, 37, 302, 404, 81, 1370, 259, 4032, 7649, 995, 4724, 5172, 37983, 11296, 39896, 20666, 8592, 3224, 2288, 50113, 15040, 21136, 18513, 3794, 6156, 3224, 1829, 11331, 38436, 28671, 20666, 12984, 6027, 12984, 4032, 3555, 22488, 11296, 4724, 30544, 5551, 3615, 23942, 23032, 21292, 3615, 1829, 6156, 2304, 43020, 7251, 30544, 4724, 33456, 3224, 41850, 8978, 25961, 16490, 9566, 10721, 8978, 6055, 28543, 13546, 21542, 42213, 5296, 15042, 5551, 9778, 3215, 8315, 11296, 46599, 6027, 2655, 6027, 1829, 37495, 22653, 11778, 16373, 15042, 20328, 5016, 1829, 5016, 14739, 8315, 8608, 45865, 8315, 2423, 39184, 10747], "avg_logprob": -0.1934267252940556, "compression_ratio": 1.6275303643724697, 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"word": " ultrasound", "probability": 0.263916015625}], "temperature": 1.0}, {"id": 289, "seek": 764624, "start": 7618.32, "end": 7646.24, "text": "وهدولة عن طريق الـ Maternal Serum يعني بسحب الـ Serum تبعتها وهنا بحكي لكم أن أحياناً أنا ممكن أشخص أشياء كثيرة إذا بشوف Anomalies بشكل معين، ماشي؟ فالـ Trisomy 121 Down Syndrome أو أكثر واحد، بس ممكن 18 و 13، نسبهم أقل وإذا فيه Neuronal Tube Defect برضه سيء", "tokens": [2407, 3224, 3215, 12610, 3660, 18871, 23032, 16572, 4587, 2423, 39184, 19188, 4660, 4210, 449, 37495, 22653, 4724, 3794, 5016, 3555, 2423, 39184, 4210, 449, 6055, 3555, 34268, 11296, 37037, 8315, 4724, 5016, 4117, 1829, 5296, 24793, 14739, 5551, 5016, 1829, 7649, 995, 14111, 41850, 3714, 43020, 5551, 8592, 9778, 9381, 5551, 8592, 1829, 16606, 9122, 12984, 48923, 11933, 15730, 4724, 8592, 38688, 1107, 298, 48872, 4724, 8592, 28820, 20449, 9957, 12399, 3714, 33599, 1829, 22807, 6156, 6027, 39184, 1765, 271, 8488, 2272, 16, 9506, 44545, 34051, 5551, 4117, 49115, 36764, 24401, 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screening» نسميه «NIPS» «Non-invasive prenatal screening» هنا إذا الواحد عنده جهاز قادر على أن يعمل هذا الأشي اللي راح يسوي إنه راح يسحب دم الأنثى بـ «peripheral blood»", "tokens": [10721, 3794, 1211, 37746, 20449, 9957, 24976, 3215, 23557, 3794, 3660, 13672, 1829, 31439, 4657, 47914, 12, 259, 39211, 659, 12241, 304, 17732, 5933, 8717, 38251, 1829, 3224, 4657, 45, 9139, 50, 5933, 4657, 47914, 12, 259, 39211, 659, 12241, 304, 17732, 5933, 34105, 11933, 15730, 2423, 14407, 24401, 43242, 3224, 10874, 3224, 31377, 12174, 18513, 2288, 15844, 14739, 7251, 25957, 1211, 23758, 16247, 8592, 1829, 13672, 1829, 12602, 39319, 7251, 3794, 45865, 36145, 3224, 12602, 39319, 7251, 3794, 5016, 3555, 11778, 2304, 16247, 1863, 12984, 7578, 4724, 39184, 4657, 610, 21240, 304, 3390, 5933], "avg_logprob": -0.20247396159296235, "compression_ratio": 1.5186915887850467, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 7760.02, "end": 7760.62, "word": "أسلوب", "probability": 0.9256591796875}, 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"text": "مرات بالرسوم المتحركة فيجيبولك راسين في جسم واحد أو شخصين أو اثنين ملتصقين زي توائم سيامية أو الكايميرة نفسها راس إنسان أو راس أسد جسم أسد وراس إنسان ودال حي وإجران فيل وخرطوم مش عارف إيش زي الحي يعني أنه من أكثر من جزء فهنا اللي بيسووا أنه بعزلوا الـ DNA", "tokens": [29973, 9307, 20666, 2288, 3794, 20498, 9673, 2655, 5016, 31747, 3660, 8978, 7435, 1829, 3555, 12610, 4117, 12602, 32277, 9957, 8978, 10874, 38251, 36764, 24401, 34051, 13412, 9778, 9381, 9957, 34051, 1975, 12984, 1863, 9957, 3714, 1211, 2655, 9381, 4587, 9957, 30767, 1829, 33427, 16373, 2304, 8608, 1829, 10943, 10632, 34051, 33251, 995, 32640, 48923, 8717, 36178, 11296, 12602, 32277, 36145, 3794, 7649, 34051, 12602, 32277, 5551, 3794, 3215, 10874, 38251, 5551, 3794, 3215, 4032, 2288, 32277, 36145, 3794, 7649, 4032, 3215, 6027, 11331, 1829, 4032, 28814, 7435, 2288, 7649, 8978, 1211, 4032, 34740, 9566, 20498, 37893, 6225, 9640, 5172, 11933, 1829, 8592, 30767, 1829, 21542, 1829, 37495, 22653, 14739, 3224, 9154, 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الـ«نيكلوتايدز» بشكل سريع جداً جداً يعني فاق السرعة بكمبيوتر سريع جداً الفكرة أنه لما نقرأ القطع هذه ونكون عارفين عنها بالأخير نقدر نعدد شو هي الـCopies ومن أنه كرمزوم هذه القطعة اللي قرناها", "tokens": [5172, 3224, 1829, 37495, 22653, 10874, 3224, 31377, 46859, 16542, 37495, 22653, 4724, 1829, 4587, 2288, 10721, 2423, 39184, 36784, 1863, 1829, 4117, 1211, 35473, 995, 25708, 11622, 5933, 4724, 8592, 28820, 8608, 16572, 3615, 10874, 28259, 14111, 10874, 28259, 14111, 37495, 22653, 6156, 995, 4587, 21136, 2288, 27884, 4724, 24793, 21292, 35473, 2288, 8608, 16572, 3615, 10874, 28259, 14111, 27188, 4117, 25720, 14739, 3224, 5296, 15042, 8717, 4587, 2288, 10721, 25062, 9566, 3615, 29538, 4032, 1863, 30544, 6225, 9640, 5172, 9957, 18871, 11296, 20666, 10721, 9778, 13546, 8717, 28543, 2288, 8717, 22488, 3215, 13412, 2407, 39896, 2423, 39184, 34, 404, 530, 4032, 27842, 14739, 3224, 9122, 2288, 2304, 11622, 20498, 29538, 25062, 9566, 27884, 13672, 1829, 12174, 2288, 8315, 11296], "avg_logprob": 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فيه احتمال أن أخذ الخلية الطبيعية ويكون فيها خلايا مصابة موجودة أو بالعكس، أخذ خلية مصابة وغالبين باقية الخلايات خلايا طبيعية، فهذا احتمال، وبدأ أنتبه أنه أنا في مرات، يعني عندي أربع احتمالات أنا أحس أن عندي نوعين من الخلايا", "tokens": [5172, 3224, 8315, 5296, 15042, 5551, 9778, 8848, 16490, 1211, 10632, 50113, 1211, 19446, 11331, 4117, 1829, 8315, 6055, 3555, 3615, 11296, 2423, 39184, 15967, 37, 36725, 3215, 2288, 3794, 11296, 8978, 3224, 1975, 33753, 2304, 6027, 14739, 5551, 9778, 8848, 33962, 1211, 10632, 41950, 21292, 3615, 10632, 4032, 1829, 30544, 8978, 11296, 16490, 15040, 25528, 3714, 9381, 16758, 3660, 3714, 29245, 23328, 3660, 34051, 20666, 3615, 4117, 3794, 12399, 5551, 9778, 8848, 16490, 1211, 10632, 3714, 9381, 16758, 3660, 4032, 17082, 6027, 3555, 9957, 4724, 995, 4587, 10632, 33962, 15040, 1829, 9307, 16490, 15040, 25528, 23032, 21292, 3615, 10632, 12399, 6156, 3224, 15730, 1975, 33753, 2304, 6027, 12399, 4032, 44510, 10721, 14739, 2655, 3555, 3224, 14739, 3224, 41850, 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"word": " الـ", "probability": 0.9716796875}, {"start": 8612.07, "end": 8612.61, "word": " «جالتكس»", "probability": 0.9934430803571429}, {"start": 8612.61, "end": 8612.79, "word": " الـ", "probability": 0.970458984375}, {"start": 8612.79, "end": 8613.29, "word": " «جالتكس»", "probability": 0.9935825892857143}, {"start": 8613.29, "end": 8613.55, "word": " الـ", "probability": 0.96923828125}, {"start": 8613.55, "end": 8614.49, "word": " «جالتكس»", "probability": 0.9935825892857143}, {"start": 8614.49, "end": 8614.61, "word": " الـ", "probability": 0.9677734375}, {"start": 8614.61, "end": 8615.27, "word": " «جالتكس»", "probability": 0.9937918526785714}, {"start": 8615.27, "end": 8615.73, "word": " الـ", "probability": 0.96728515625}, {"start": 8615.73, "end": 8616.99, "word": " «جالتكس»", "probability": 0.9938616071428571}, {"start": 8616.99, "end": 8623.15, "word": " الـ", "probability": 0.9638671875}, {"start": 8623.15, "end": 8626.11, "word": " «جالتكس", "probability": 0.993896484375}], "temperature": 1.0}, {"id": 327, "seek": 863821, "start": 8626.16, "end": 8638.22, "text": "الله يعافيكم ويرضى عليكم إن شاء الله تكون الأمور واضحة وتكون مستفيدين إن شاء الله الله حيكم أهلا و أهلا نشوفكم الأسبوع الجاية إن شاء الله", "tokens": [6027, 43761, 37495, 31845, 1829, 24793, 4032, 13546, 11242, 7578, 25894, 24793, 36145, 13412, 16606, 21984, 6055, 30544, 16247, 2304, 13063, 4032, 46958, 5016, 3660, 4032, 2655, 30544, 3714, 14851, 5172, 25708, 9957, 36145, 13412, 16606, 21984, 21984, 11331, 1829, 24793, 5551, 3224, 15040, 4032, 5551, 3224, 15040, 8717, 8592, 38688, 24793, 16247, 35457, 45367, 25724, 995, 10632, 36145, 13412, 16606, 21984], "avg_logprob": -0.18501984079678854, "compression_ratio": 1.8721804511278195, "no_speech_prob": 9.5367431640625e-07, "words": [{"start": 8626.16, "end": 8626.54, "word": "الله", "probability": 0.739013671875}, {"start": 8626.54, "end": 8627.28, "word": " يعافيكم", "probability": 0.68695068359375}, {"start": 8627.28, "end": 8627.78, "word": " ويرضى", "probability": 0.9219970703125}, {"start": 8627.78, "end": 8628.28, "word": " عليكم", "probability": 0.973388671875}, {"start": 8628.28, "end": 8628.46, "word": " إن", "probability": 0.2457275390625}, {"start": 8628.46, "end": 8628.6, "word": " شاء", "probability": 0.970703125}, {"start": 8628.6, "end": 8628.66, "word": " الله", "probability": 0.9365234375}, {"start": 8628.66, "end": 8628.98, "word": " تكون", "probability": 0.9658203125}, {"start": 8628.98, "end": 8629.4, "word": " الأمور", "probability": 0.9900716145833334}, {"start": 8629.4, "end": 8630.16, "word": " واضحة", "probability": 0.981201171875}, {"start": 8630.16, "end": 8631.42, "word": " وتكون", "probability": 0.6869303385416666}, {"start": 8631.42, "end": 8632.62, "word": " مستفيدين", "probability": 0.95400390625}, {"start": 8632.62, "end": 8632.82, "word": " إن", "probability": 0.6826171875}, {"start": 8632.82, "end": 8632.98, "word": " شاء", "probability": 0.991455078125}, {"start": 8632.98, "end": 8633.42, "word": " الله", "probability": 0.95361328125}, {"start": 8633.42, "end": 8634.12, "word": " الله", "probability": 0.3486328125}, {"start": 8634.12, "end": 8634.72, "word": " حيكم", "probability": 0.6398111979166666}, {"start": 8634.72, "end": 8635.5, "word": " أهلا", "probability": 0.91455078125}, {"start": 8635.5, "end": 8635.7, "word": " و", "probability": 0.7880859375}, {"start": 8635.7, "end": 8635.98, "word": " أهلا", "probability": 0.96728515625}, {"start": 8635.98, "end": 8636.92, "word": " نشوفكم", "probability": 0.87060546875}, {"start": 8636.92, "end": 8637.32, "word": " الأسبوع", "probability": 0.9191080729166666}, {"start": 8637.32, "end": 8637.68, "word": " الجاية", "probability": 0.7293294270833334}, {"start": 8637.68, "end": 8637.88, "word": " إن", "probability": 0.97021484375}, {"start": 8637.88, "end": 8638.0, "word": " شاء", "probability": 0.991455078125}, {"start": 8638.0, "end": 8638.22, "word": " الله", "probability": 0.96826171875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 8643.1869375, "duration_after_vad": 8491.017843750098}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/fBzW7egRH9k_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/fBzW7egRH9k_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..5c54d063dc85d5400ff4a9a483d11c3a52aee73e
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/fBzW7egRH9k_postprocess.srt
@@ -0,0 +1,2196 @@
+1
+00:00:00,880 --> 00:00:05,640
+الجزء الـ slide هذا بعد ما اتكلمنا كيف الـ DNA
+
+2
+00:00:05,640 --> 00:00:12,620
+شكله وكيف بتم عملية انقسام الخلايا أو نوعين
+
+3
+00:00:12,620 --> 00:00:17,560
+الانقسام بهدف ابقاء عدد الخلايا كما هما اللي هو
+
+4
+00:00:17,560 --> 00:00:24,020
+الـ Mitosis عشان يظل عدد الخلايا زي ما هماوالـ
+
+5
+00:00:24,020 --> 00:00:31,480
+Meiosis اللي هو موضوع لما يكون اللي هو الانخسام
+
+6
+00:00:31,480 --> 00:00:35,780
+المنصف حيث أنه يطلع عند الـ Gametes و بالـ Males و
+
+7
+00:00:35,780 --> 00:00:41,780
+الـ Females بتتبع فطوات قريبة من بعض على مرحلتين،
+
+8
+00:00:41,780 --> 00:00:47,140
+المرحل الأولى بتبدأ الخلية 2N بتصير 4N و بعدين
+
+9
+00:00:47,140 --> 00:00:53,770
+بتنقسم إلى الخلايا تبعتهااللي هو سواءً الـ Sperms
+
+10
+00:00:53,770 --> 00:00:59,970
+أو الـ Egg اللي بتطلع الآن الموضوع الثاني راح نبدأ
+
+11
+00:00:59,970 --> 00:01:06,910
+اليوم إحنا بعد ما بدأنا نحكي إنه الـ DNA هو المصدر
+
+12
+00:01:06,910 --> 00:01:11,450
+اللي بيحدد كيف راح يكون ترتيب البروتين أو الـ
+
+13
+00:01:11,450 --> 00:01:17,990
+Primary Structure تبع البروتين اللي هو ترتيب الـ
+
+14
+00:01:18,750 --> 00:01:21,290
+ترتيب الـ Amino Acids اللي هو الـ Primary
+
+15
+00:01:21,290 --> 00:01:24,650
+Structure للبروتين ويكون ترتيب الـ Amino Acids
+
+16
+00:01:24,650 --> 00:01:28,750
+طبعاً لازم تكونوا عارفين من ال Biochemistry أنه في
+
+17
+00:01:28,750 --> 00:01:32,950
+عنا عشرين أو واحد وعشرين Amino Acids حسب مرات تبقى
+
+18
+00:01:32,950 --> 00:01:38,230
+هيك ولي هيك فأحد هذه الطرق اللي هو حاطينها تحت
+
+19
+00:01:38,230 --> 00:01:42,110
+اللي هي هنا Abbreviations for Amino Acids فعنا
+
+20
+00:01:42,110 --> 00:01:50,100
+الألانين والأرجانين والأسبارجانين بالشكل هذاففي
+
+21
+00:01:50,100 --> 00:02:00,360
+ثلاث نظم لكتابة أسماء الـ Amino Acids في الـ
+
+22
+00:02:00,360 --> 00:02:07,500
+.. أنا والله خلّيني أشوف الكاميرا الـ .. إيه قاعد
+
+23
+00:02:07,500 --> 00:02:12,400
+المشاركة؟ المشكلة زي الـ «زوم» ما كنت أنا أدخل من
+
+24
+00:02:12,400 --> 00:02:18,530
+قبل مش راضي .. إيش اسمه؟stop recording share
+
+25
+00:02:18,530 --> 00:02:24,150
+screen start video
+
+26
+00:02:24,150 --> 00:02:29,450
+ناخذ التطبيق PowerPoint
+
+27
+00:02:51,820 --> 00:02:57,580
+وأقول له start my video هذا الجهاز مش جهازي ما هو
+
+28
+00:02:57,580 --> 00:03:05,960
+اسمه؟ مش جهازي؟ فمش عارف 100% طيب فبالنسبة لهناك
+
+29
+00:03:05,960 --> 00:03:10,480
+ثلاثة أنظمة للتعريف الـ «among us» بالعشرين اللي
+
+30
+00:03:10,480 --> 00:03:15,780
+هما يأمل ثلاث أحرف ذلك ألانين أو حرف الـA أو بالتو
+
+31
+00:03:15,780 --> 00:03:21,950
+كامل ألانين فهذه أسماءالـ Amino Acids وكتير من
+
+32
+00:03:21,950 --> 00:03:32,770
+الظواهر الحيوية والظواهر في حياة الإنسان نعتمد
+
+33
+00:03:32,770 --> 00:03:36,770
+على الـ Amino Acids يعني مثلا فينال، كيوتون،
+
+34
+00:03:36,770 --> 00:03:41,030
+نيوريا، مرض نتيجة الفينال الأنانين Metabolism
+
+35
+00:03:41,030 --> 00:03:47,430
+Problemأو مثلًا في عندنا Serine Protease أو عندنا
+
+36
+00:03:47,430 --> 00:03:51,830
+كذا فنستخدم كثير مصطلحات اللي دخل بالـ Amino Acids
+
+37
+00:03:51,830 --> 00:04:01,330
+فالآن حتى نفهم القطع اللي فوق اللي هي الـ Genetic
+
+38
+00:04:01,330 --> 00:04:11,380
+Code هذه طريقة ترميز الـ Amino Acids من خلالأحرف و
+
+39
+00:04:11,380 --> 00:04:16,020
+الـ Bases أو الـ Nitrogenous Bases تبعات الـ
+
+40
+00:04:16,020 --> 00:04:21,000
+Nucleotides فمن تركيب الـ DNA بنحوله لتركيب أو
+
+41
+00:04:21,000 --> 00:04:26,860
+ترتيب الـ Amino Acids فلو كان اللي اكتشفوه العلماء
+
+42
+00:04:26,860 --> 00:04:36,760
+أنه لو كان الأمر بيكون من خلال Single Nucleotide
+
+43
+00:04:38,390 --> 00:04:45,410
+كان نقدر نعمل شفرة لـ 4 amino acids لو كان عندي
+
+44
+00:04:45,410 --> 00:04:50,870
+Two Nucleotides بيثيروا هم اللي بيعملوا الـ
+
+45
+00:04:55,700 --> 00:05:01,540
+الـ Coding أو التشفير أنه Two Amino Acids فالأول
+
+46
+00:05:01,540 --> 00:05:05,380
+أربعة فينا واحد من أربع احتمالات والثاني أربع
+
+47
+00:05:05,380 --> 00:05:08,880
+احتمالات ثانية ففي الحالة دي راح يكون ستاشر
+
+48
+00:05:08,880 --> 00:05:15,560
+Nucleus ستاشر Amino Acids نقدر نرمز إليهم فثبت إنه
+
+49
+00:05:15,560 --> 00:05:20,560
+لأ هم ثلاثة كل ثلاثة بنقروا مع بعض وكل ثلاثة مع
+
+50
+00:05:20,560 --> 00:05:25,480
+بعض برمزوا ل Amino Acid واحدفعشان هيك بنسميهم
+
+51
+00:05:25,480 --> 00:05:30,240
+Codon أو Triplet أو كده عبارة عن ثلاث من الـ
+
+52
+00:05:30,240 --> 00:05:34,960
+Nucleotides حتى يرمزوا لواحد من الـ Amino Acid
+
+53
+00:05:34,960 --> 00:05:38,980
+طبعاً أربعة بأربعة بأربعة بتصير أربعة و ستين
+
+54
+00:05:38,980 --> 00:05:44,300
+فالأربعة و ستين زيادة عن الأشرين Amino Acid بس
+
+55
+00:05:44,300 --> 00:05:47,960
+بتغطيهم و راح نشوف كيف الأمور تتطور
+
+56
+00:05:52,380 --> 00:05:57,020
+الجدول هذا أمامكم حاطين بالأول ما هي الـ First
+
+57
+00:05:57,020 --> 00:06:03,400
+Base مرات بتكون U, C, A أو G طبعاً الـ U لأنها حلت
+
+58
+00:06:03,400 --> 00:06:10,780
+في الـ RNA مش الـ DNA الـ RNA حلت بدل الـ T الـ
+
+59
+00:06:10,780 --> 00:06:17,900
+Second Base هذا اللي هو ترتيبهم U, C, A, G وبعدين
+
+60
+00:06:17,900 --> 00:06:22,510
+هنا الـ Third Baseحاطينها بالترتيب شُلّي عندنا
+
+61
+00:06:22,510 --> 00:06:29,290
+فبنلاحظ إذا كان عندنا ترتيب مثلا كودون ثلاثي U U U
+
+62
+00:06:29,290 --> 00:06:36,710
+هذا فلع الألاني U U C فلع الألاني كمان U U A لـ C
+
+63
+00:06:36,710 --> 00:06:46,690
+U U G لـ C C U U لـ C C U C لـ Cالـ PUA Lucy يعني
+
+64
+00:06:46,690 --> 00:06:52,150
+إنها أربعين، إنها أربعة وستين، بده رمز للعشرين
+
+65
+00:06:52,150 --> 00:06:56,610
+فيكم، فبصير عنده تكرارات، بعض الـ Amino Acids يمكن
+
+66
+00:06:56,610 --> 00:07:01,090
+مالهاش غير مثلًا زي المستانيينين الـ AUG هذا
+
+67
+00:07:01,090 --> 00:07:04,810
+الترتيب تبعها، فالـ
+
+68
+00:07:09,290 --> 00:07:17,410
+الآن الترتيبات هذه زي ما أنتم شايفين عشان يكون الـ
+
+69
+00:07:17,410 --> 00:07:24,310
+… نرمز لـ 20 Amino Acids من خلال ثلاثيات من الـ
+
+70
+00:07:24,310 --> 00:07:29,470
+Nucleotides ثلاثيات من الـ Nitrogen Bases بحيث أنه
+
+71
+00:07:29,470 --> 00:07:35,810
+يعطينا إياها بس بدنا نلاحظ كمان شغل تاني إذا
+
+72
+00:07:35,810 --> 00:07:45,430
+بتنتبهوا للجدولUAA وUAG وUGA هدولة stop كودهم
+
+73
+00:07:45,430 --> 00:07:51,870
+انتبهوا هدولة الثلاثة حاطينهم انه يعني عشان
+
+74
+00:07:51,870 --> 00:07:58,390
+القراءة تبدأ من محل معين وتنتهي في محل معين بالأول
+
+75
+00:07:58,390 --> 00:08:03,160
+لازم يكون عندي أنا بدور على ال well startهي لازم
+
+76
+00:08:03,160 --> 00:08:08,480
+يكون start كده مش
+
+77
+00:08:08,480 --> 00:08:16,620
+شايف أين برولين وكده وفيه ال stop ال stop عشان
+
+78
+00:08:16,620 --> 00:08:25,780
+يوقف قراءة ال RNA في محل معين هنا ال start مانيش
+
+79
+00:08:25,780 --> 00:08:30,220
+شايفه بس
+
+80
+00:08:30,220 --> 00:08:35,730
+لازم يكون في محلبيخلّي النظام
+
+81
+00:08:35,730 --> 00:08:42,850
+في قراية الـ Messenger RNA ويعني في عملية الـ
+
+82
+00:08:42,850 --> 00:08:47,570
+Transcription للـ DNA لـ Messenger RNA بدي يقولّه
+
+83
+00:08:47,570 --> 00:08:51,930
+ابدأ من هذه المكانة فالمحل البداية لازم يكون ترتيب
+
+84
+00:08:51,930 --> 00:08:56,110
+معين بيقولّه ابدأ من هنا وفي نفس الوقت في إشي
+
+85
+00:08:56,110 --> 00:09:01,620
+بيقولّه انتهي هنا فهذه النقطة اللي بدنا إياهاوهيك
+
+86
+00:09:01,620 --> 00:09:07,340
+النظام اللي بتتم من خلاله ترميز الـ Amino Acids
+
+87
+00:09:07,340 --> 00:09:11,820
+اللي بتدخل في ترتيب البروتيد الناتج عن هذا الجين
+
+88
+00:09:11,820 --> 00:09:17,340
+فالجين هو اللي في الـ DNA هو اللي راح يعطينا الـ
+
+89
+00:09:17,340 --> 00:09:22,420
+Messenger RNA هو اللي راح يعطينا إياه فأظن هنا الـ
+
+90
+00:09:22,420 --> 00:09:28,040
+ATG وطبعاً يعني الفكرة أنه إحنا بنقرا الـ
+
+91
+00:09:28,040 --> 00:09:29,120
+Transcription
+
+92
+00:09:31,290 --> 00:09:35,970
+كل ثلاثة مع بعض، كل ثلاثة مع بعض، كل ثلاثة مع بعض
+
+93
+00:09:35,970 --> 00:09:40,650
+فالـ Transcription أعطانا الـ Messenger RNA والـ
+
+94
+00:09:40,650 --> 00:09:46,490
+Translation راح تعطينا الـ Amino Acids حطين هنا
+
+95
+00:09:46,490 --> 00:09:54,590
+الأسماء اللي هي المفروض بالأحرف لـ Amino
+
+96
+00:09:54,590 --> 00:10:00,350
+Acids اللي تدخل في تركيب البروتين هذافهذه اسمها
+
+97
+00:10:00,350 --> 00:10:07,490
+كلمات مهمة كثير اللي هي أنه في عندي startup Start
+
+98
+00:10:07,490 --> 00:10:13,250
+on Codon و بعدين ببدأ عملية Transcription وعطينا
+
+99
+00:10:13,250 --> 00:10:19,110
+الـ Messenger RNA الـ Messenger RNA كل ثلاثة بدخل
+
+100
+00:10:19,110 --> 00:10:25,610
+فيه اللي هو Transferial RNAبتبركب على الـ ribosome
+
+101
+00:10:25,610 --> 00:10:31,590
+اللي فيه ribosome RNA على الـ messenger RNA بحيث
+
+102
+00:10:31,590 --> 00:10:38,430
+يقرأ الـ الـ الـ الـ البروتينات الموجودة بحيث
+
+103
+00:10:38,430 --> 00:10:45,110
+يعطينا بالأقيل البروتين ماشي فالـ translational
+
+104
+00:10:45,110 --> 00:10:49,210
+reading frame is determined by the AUG initiator
+
+105
+00:10:49,210 --> 00:10:53,840
+codon اللي حفظ عليه السحنوالـ Subsequent Codewords
+
+106
+00:10:53,840 --> 00:10:56,200
+Specifying the Binary Assets ‏are indicated in
+
+107
+00:10:56,200 --> 00:11:00,440
+blue، ناشي ‏The two other potential frames are not
+
+108
+00:11:00,440 --> 00:11:09,560
+tuned، ناشي فالـ هنا الـ AUG هو البداية يعني هذا
+
+109
+00:11:09,560 --> 00:11:16,920
+أجى Messenger RNA عشان يكون خربط أو لا إشيلحد
+
+110
+00:11:16,920 --> 00:11:23,140
+بيصير الـ Ribosome يبدأ يلف ويشبك عليه وينتبه لحد
+
+111
+00:11:23,140 --> 00:11:28,220
+ما يشكوك هدولة في ثلاثة بعدين بيصير يقرا فيهم فهيك
+
+112
+00:11:28,220 --> 00:11:34,700
+الظاهرة اللي بتتم في عملية
+
+113
+00:11:34,700 --> 00:11:40,520
+بناء البروتين من الـ Messenger RNA من الـ DNA
+
+114
+00:11:40,520 --> 00:11:44,880
+وبتكون هي هيك موجودة إن شاء الله الأمور واضحة
+
+115
+00:11:49,250 --> 00:11:54,110
+على الـ WhatsApp احكولي إذا أنا آسف جدا اليوم غريب
+
+116
+00:11:54,110 --> 00:11:57,870
+يعني إن شاء الله المرة الجاية بتكون أحسن وانا ماني
+
+117
+00:11:57,870 --> 00:12:02,490
+عارف شو اللي صار يعني بدا يمكن أعد فرمات الـ hard
+
+118
+00:12:02,490 --> 00:12:07,670
+disk إذا في أسئلة ابعتلي إياها على الـ WhatsApp
+
+119
+00:12:07,670 --> 00:12:14,510
+أنا أفتح الأثنين أثناء اللي نيجي نتطلع على بعض الـ
+
+120
+00:12:29,340 --> 00:12:35,840
+الآن هناك ترتيب مطلوبة حتى يلف السلك تبع الـ DNA
+
+121
+00:12:35,840 --> 00:12:41,720
+على حاله ففيه إيش اسمه الـ nucleosomes وإيش اسمه
+
+122
+00:12:41,720 --> 00:12:47,020
+الـ histones والسنتين مطلوبات حتى الـ DNA يلف على
+
+123
+00:12:47,020 --> 00:12:53,360
+حاله بغض انه يصير عملية برضه بالشكل المطلوب لعملية
+
+124
+00:12:53,360 --> 00:13:01,300
+الـ meiosis و الـ mitosisالـ .. الآن اتكلمت هيك
+
+125
+00:13:01,300 --> 00:13:07,520
+بشكل .. حتى يعني نفهم جانب آخر وشو ضرورة الواحد
+
+126
+00:13:07,520 --> 00:13:14,520
+يكون فاهم هيك بشكل مبدأ Concept هيك ال .. ال .. ال
+
+127
+00:13:14,520 --> 00:13:18,300
+.. ليش الـ Nucleosomes و الـ Histones غير قضية
+
+128
+00:13:18,300 --> 00:13:23,820
+احتجاج نقلهم في عملية .. في عملية انقسام الخلية
+
+129
+00:13:24,820 --> 00:13:31,580
+اللي هي ظاهرة التحكم إنه أحيانًا كثيرة بتتم التحكم
+
+130
+00:13:31,580 --> 00:13:42,960
+بالـ DNA عن طريق آليات، Mechanisms تستطلب أنه أدد
+
+131
+00:13:42,960 --> 00:13:49,420
+كبير من الجينات يتم تشغيلها في مكان معين أو
+
+132
+00:13:49,420 --> 00:13:54,250
+توقيفها في مجال آخروهذه إليها دخل أحيانًا أو إليها
+
+133
+00:13:54,250 --> 00:13:59,370
+دخل مهم في اللي بنسميهم الـ Polygenic Diseases
+
+134
+00:13:59,370 --> 00:14:06,330
+يعني الأمراض اللي فيها عدد كبير مشترك من الجينات
+
+135
+00:14:06,330 --> 00:14:12,250
+بتسبب المرض هذه بتكون أنه عدد كبير مش جين واحد
+
+136
+00:14:12,250 --> 00:14:16,010
+يعني إحنا راح ناخد بعد شوية بإنه بنقسم الأمراض
+
+137
+00:14:16,010 --> 00:14:21,340
+لثلاث أنواع ورافياًفيه كرموزومال يعني كرموزوم كامل
+
+138
+00:14:21,340 --> 00:14:27,600
+بار، ذاد، نقص، كده وفيه Mendelian يعني One-G اللي
+
+139
+00:14:27,600 --> 00:14:31,160
+هو اللي عامل المشكلة فدول أمراض بشكل عام نادرة
+
+140
+00:14:31,160 --> 00:14:36,260
+الأمراض غالبية العظمة زي السكري، الضغط، الربوء،
+
+141
+00:14:36,260 --> 00:14:40,620
+كده هذه أشياء بتلاقي أن مجموعة كبيرة من الجينات
+
+142
+00:14:40,620 --> 00:14:44,540
+بتتم تأثير
+
+143
+00:14:44,540 --> 00:14:50,610
+عليهاطريقة كيف إنه عدد كبير من الجينات سواء تشتغل
+
+144
+00:14:50,610 --> 00:14:54,890
+كثير أو تشتغل قليل أو كيف تختلط بطريقة معينة أو
+
+145
+00:14:54,890 --> 00:14:59,270
+أخرى باعتمد على ما يسمى الـ Epigenetic Mechanisms
+
+146
+00:14:59,270 --> 00:15:04,510
+فالـ Epigenetic Mechanisms على قل المشهورات منهم
+
+147
+00:15:04,510 --> 00:15:09,370
+غير اللي بيسموه Micro RNA بتصير عملية الـ DNA
+
+148
+00:15:09,370 --> 00:15:14,820
+Methylationيعني الـ Retinal Group بتيجي وتشبك على
+
+149
+00:15:14,820 --> 00:15:23,700
+قطعة معينة أو على نيوكلوتايد معين في الـ DNA لما
+
+150
+00:15:23,700 --> 00:15:30,920
+تصير عندي الـ DNA methylation بتغير وظيفة الجين
+
+151
+00:15:30,920 --> 00:15:35,900
+هذا وطريقة تانية اللي هي الـ Modification لـ
+
+152
+00:15:35,900 --> 00:15:39,780
+Histone Tail الـ Histone و الـ Nucleosomes و الـ
+
+153
+00:15:39,780 --> 00:15:44,650
+Histonesبصيرهم برضه عمليات «metallation» وهدولة
+
+154
+00:15:44,650 --> 00:15:48,290
+يعني بيغيروا
+
+155
+00:15:48,290 --> 00:15:54,510
+في شكل وظيفة الـ «DNA» بس ما بيغيروا في ترتيب الـ
+
+156
+00:15:54,510 --> 00:15:57,310
+«Nucleotides» و لا بيغيروا يعني ما بنقدر نعتبرهم
+
+157
+00:15:57,310 --> 00:16:02,830
+تفرات ما بنقدر نعتبرهم زي بقية الأمراض لما ناخد
+
+158
+00:16:02,830 --> 00:16:07,590
+عليها الـ «coding» فـ Epigenetic يعني بيسموه علم
+
+159
+00:16:07,590 --> 00:16:14,740
+التخلقبكون إنه فيه اختلالات في وظيفة الـ DNA على
+
+160
+00:16:14,740 --> 00:16:20,980
+مستوى حدد كبير من الجينات مع بعض بكون نتيجة ظواهر
+
+161
+00:16:20,980 --> 00:16:25,180
+زي عملية الـ methylation للـ DNA أو تغيير على الـ
+
+162
+00:16:25,180 --> 00:16:30,160
+histones أو الـ nucleosomes اللي مطلوبة حتى لف الـ
+
+163
+00:16:30,160 --> 00:16:34,320
+DNA بالشكل اللي بنشوفه فوق حتى يعطينا كرومزوم شكل
+
+164
+00:16:34,320 --> 00:16:38,840
+مضغوط يعرف يفصل عن بعضهفيه آليات أخرى للـ
+
+165
+00:16:38,840 --> 00:16:45,140
+Epigenetics نحكي عنها بعدين بس يعني هاي بواهر
+
+166
+00:16:45,140 --> 00:16:53,540
+موجودة وأشياء مهمة هنا الفرق الكيماوي لـ Cytosine
+
+167
+00:16:53,540 --> 00:16:58,980
+مع الـ 5-Methylcytosine وممكن 5
+
+168
+00:16:58,980 --> 00:17:04,030
+-Hydroxynethylcytosine كيف أنه بتصير تغييراتالـ
+
+169
+00:17:04,030 --> 00:17:09,230
+DNA على مستوى الـ DNA لطبيعة الـ methylation وهاي
+
+170
+00:17:09,230 --> 00:17:18,550
+حسب درجتها وكمياتها بتأثر على وظيفة الـ DNA اليوم
+
+171
+00:17:18,550 --> 00:17:27,630
+والآن نتيجة ضرفنا يعني يمكن راح يكون صعب أن أسمع
+
+172
+00:17:27,630 --> 00:17:31,430
+منكم بس إذا فيها أي أسئلة ان شاء الله بالـ group
+
+173
+00:17:31,430 --> 00:17:33,670
+أو بكذا بنسويها مرة تانية
+
+174
+00:17:36,640 --> 00:17:43,380
+الآن أحيانًا الترتيب
+
+175
+00:17:43,380 --> 00:17:50,090
+وكيف الـ DNA راح يصيرأحنا بالـ Nucleus الأصل إنه
+
+176
+00:17:50,090 --> 00:17:56,890
+الكرموزومات كلها بالأول يعني زي ما تقولوا خاردة
+
+177
+00:17:56,890 --> 00:18:03,270
+حالها و تستخدم عشان تقرأ الجينات و كده و إنه
+
+178
+00:18:03,270 --> 00:18:08,270
+دايماً لما يصير عندي قراءة لجين معين لازم بالأول
+
+179
+00:18:08,270 --> 00:18:16,540
+يصير عملية تنشيط لهذا الجينيفك حتى يبدأ يقرأ أمن
+
+180
+00:18:16,540 --> 00:18:22,260
+الـ DNA تبعه ويعطينا الـ Messenger RNA في عندي
+
+181
+00:18:22,260 --> 00:18:29,200
+بيسموها الـ Promoter Regions يعني إشي بده يفهم
+
+182
+00:18:29,200 --> 00:18:36,020
+آليات النسخ أنه ابدأ من هنا وهي اللي هي بتتم عملية
+
+183
+00:18:36,020 --> 00:18:40,400
+استفادة منها في التحكم في وظيفة الـ DNA عشان يبدأ
+
+184
+00:18:40,400 --> 00:18:46,590
+يشتغلوهدولة يعني آليات التحكم ممكن إشي مباشر قبل
+
+185
+00:18:46,590 --> 00:18:51,210
+الـ DNA زي هيك الـ Promoter Region بنسميها أو
+
+186
+00:18:51,210 --> 00:18:57,010
+أحيانًا بتكون قطعة أخرى من مسافة بعيدة يعني زي هيك
+
+187
+00:18:57,010 --> 00:19:03,010
+ممثلينا إنه إشي قبله مسافة طويلة بس برضه بتدخل إنه
+
+188
+00:19:03,010 --> 00:19:09,270
+يتحكم Long Range Regulatory Element فبتلاقي من محل
+
+189
+00:19:09,270 --> 00:19:17,900
+بعيدحتى يتحكم بالـ Intel وهذا يعني يبدو
+
+190
+00:19:17,900 --> 00:19:24,460
+الواحد يستوعبها على إنه هي الظواهر
+
+191
+00:19:24,460 --> 00:19:29,340
+اللي احنا الآن بلاحظها
+
+192
+00:19:29,340 --> 00:19:38,960
+وبتحاول تفسر كيفية وظيفة هذا النظام المعطليعني
+
+193
+00:19:38,960 --> 00:19:45,280
+احنا صحيح في عندنا 25 ألف جين بس مش بس ان الواحد
+
+194
+00:19:45,280 --> 00:19:49,700
+جين وانتهينا يعني نفس الجين ممكن أكتر من قطعة لازم
+
+195
+00:19:49,700 --> 00:19:54,920
+الجين إله بداية وإله نهاية 25 ألف جين لكل أنواع
+
+196
+00:19:54,920 --> 00:20:00,100
+خلايا الجسم في الخلية مثلا الفلانية مثلا خلية عضلة
+
+197
+00:20:00,100 --> 00:20:05,320
+بدها Acetinomycin عشان هي عضلةبينما مثلًا خليط
+
+198
+00:20:05,320 --> 00:20:09,560
+الدم الحمراء بدها Hemoglobin خليط المناعة بدها
+
+199
+00:20:09,560 --> 00:20:14,060
+Immunoglobulin البروتين تبعها فكيف كل واحدة تهتزي
+
+200
+00:20:14,060 --> 00:20:20,600
+إنه تنشط ولا تتطبط ولا تغير ولا كذا من خلال أنظمة
+
+201
+00:20:20,600 --> 00:20:26,600
+التحكم فجزء من أنظمة التحكم في شكل الـ DNA نفسه
+
+202
+00:20:26,600 --> 00:20:30,980
+طريقة تركيبه و تركيبه حتى يستطيع إنه ينقص من قسم
+
+203
+00:20:30,980 --> 00:20:41,710
+الخلاياوفي نفس الوقت حتى تكون وظيفة يعني حتى تقوم
+
+204
+00:20:41,710 --> 00:20:49,090
+الخلية بوظيفتها الـ Methylation هي سؤال احنا يعني
+
+205
+00:20:49,090 --> 00:20:52,810
+حالياً أنا لست على الطلاع إنه إله فايدة أو وظيفة
+
+206
+00:20:52,810 --> 00:20:58,690
+معينة، ظاهرة و بتحدث يعني الأحيان
+
+207
+00:20:59,330 --> 00:21:03,430
+إذا قعدت نستفيد منها البروتينات مثلا بتمن عملية
+
+208
+00:21:03,430 --> 00:21:07,430
+الـ glycosylation للبروتين كل البروتين وقعدت
+
+209
+00:21:07,430 --> 00:21:11,090
+نستفيد منها في التحكم في السكري لإنه بنشوف قداش
+
+210
+00:21:11,090 --> 00:21:15,150
+نسبة الـ glycosylated hemoglobin percentage فهي
+
+211
+00:21:15,150 --> 00:21:23,490
+أعتبرها ظاهرة بتحدث ودرجتها ووجودها
+
+212
+00:21:23,490 --> 00:21:27,450
+يعني هي ظاهرة بتحدث، هاي أولاً، بسشو هدفها؟ أنا
+
+213
+00:21:27,450 --> 00:21:31,690
+ماعندي اطلاع إنه إلها وظيفة معينة بس لما تحدث
+
+214
+00:21:31,690 --> 00:21:37,810
+بتأثر في وظيفة الـ Gene بحيث أنه بنتج عنه اختلافات
+
+215
+00:21:37,810 --> 00:21:44,390
+والجيار المختلفة ممكن
+
+216
+00:21:44,390 --> 00:21:49,480
+يعني بقول إنه بيأثر على وظيفة الـ Gene سواءأحيانًا
+
+217
+00:21:49,480 --> 00:21:52,860
+بعضها ممكن يتنشط وبعضها ممكن يتطبط، أنا مش
+
+218
+00:21:52,860 --> 00:21:56,280
+بالضرورة يعني في كثير من الأمراض مثلًا، الأمراض
+
+219
+00:21:56,280 --> 00:21:59,680
+اللي ربه أنا على خيلها عليها، في مجموعة جينات
+
+220
+00:21:59,680 --> 00:22:05,160
+كثيرة بتصير لها عملية تنشيط، وفي جينات أخرى بتصير
+
+221
+00:22:05,160 --> 00:22:11,360
+عملية تخبير، وهذه يعني زي ما بقول يعني رابط المثال
+
+222
+00:22:11,360 --> 00:22:16,130
+قبل ذلك، زي فرقة موسيقية يعنيالـ Orchestra
+
+223
+00:22:16,130 --> 00:22:21,410
+بتشوفوهم مثلا قاعدين حوالي ميت عازف فالمية مثلا في
+
+224
+00:22:21,410 --> 00:22:26,370
+لحظة معينة بدك كلهم أو ربعهم أو جزء معين أو نوعي
+
+225
+00:22:26,370 --> 00:22:31,490
+معين يتنشطوا الجزء بدك ياهم يتطبطوا فهذه كلها
+
+226
+00:22:31,490 --> 00:22:36,870
+واردة يعني فهي ظاهرة بتحدث وهي ظاهرة تشارك في
+
+227
+00:22:36,870 --> 00:22:44,890
+التحكم في وظيفة الـ DNA وبالتالي قد تكون لها يعني
+
+228
+00:22:45,370 --> 00:22:50,570
+دور في حكينا الأمراض اللي بنعتبرها polygenic يعني
+
+229
+00:22:50,570 --> 00:22:55,190
+الأمراض اللي فيها ليس جين واحد، مش مندالين، راح
+
+230
+00:22:55,190 --> 00:22:59,290
+تكون الأمراض اللي هي زي الضغط والسكري والربو أشياء
+
+231
+00:22:59,290 --> 00:23:05,290
+ويراتية، أشياء تكثر في عائلات معينة بس وجزة منها
+
+232
+00:23:05,290 --> 00:23:10,070
+ويراتي صحيح ولكن مش مندالين، مش جين واحد هو المسبب
+
+233
+00:23:10,070 --> 00:23:10,510
+للمرض
+
+234
+00:23:15,670 --> 00:23:21,130
+فأحيانًا اللي بدنا
+
+235
+00:23:21,130 --> 00:23:25,630
+ننتبهه من الظواهر الأخرى اللي بتعمل واحنا بنحاول
+
+236
+00:23:25,630 --> 00:23:32,310
+نصف شو بيصير في جسم الإنسان أنه مثلًا
+
+237
+00:23:32,310 --> 00:23:38,390
+أنا لأني متأكد 100% من هذا الكلام وفي جانب درسته
+
+238
+00:23:38,390 --> 00:23:43,510
+بشكل كبيربالنسبة للـ Protein تبع الـ
+
+239
+00:23:43,510 --> 00:23:46,750
+Immunoglobulin تبع اللي موجود بيشتغل في الـ B
+
+240
+00:23:46,750 --> 00:23:52,990
+-Lymphocyte ماشي ال Immunoglobulin أنا عندي Two
+
+241
+00:23:52,990 --> 00:23:57,850
+copies of the DNA واحد من أبوي واحد من أمي أثنانهم
+
+242
+00:23:57,850 --> 00:24:03,650
+عليهم جزء من الـ DNA للـ Heavy Chain للـ Heavy
+
+243
+00:24:03,650 --> 00:24:08,090
+Chain وفيه لل Light Chain أربع copies يعني فنتين
+
+244
+00:24:08,090 --> 00:24:13,940
+فنتينوالـ Heavy Chain واحد بواحد ففيه Syntax بس في
+
+245
+00:24:13,940 --> 00:24:20,140
+أي خلية من الـ B-Lymphocyte لوحدها بتكون فقط نسخة
+
+246
+00:24:20,140 --> 00:24:24,120
+واحدة من الـ Heavy Chain ونسخة واحدة من الـ Light
+
+247
+00:24:24,120 --> 00:24:27,780
+Chain هم اللي شقالين بالنسبة للـ Heavy Chain كان
+
+248
+00:24:27,780 --> 00:24:32,060
+عندي خيارين طلعلي خيار واحد أو بس واحد هو الفعال
+
+249
+00:24:32,060 --> 00:24:36,380
+الثاني بيبقى له ساكن لأن لا يتم عملية الـ
+
+250
+00:24:36,380 --> 00:24:40,500
+Transcription و Translation لهوبالنسبة للـ Light
+
+251
+00:24:40,500 --> 00:24:44,600
+Chain مع أن عندي أربع احتمالات بس في أي خلية بيكون
+
+252
+00:24:44,600 --> 00:24:52,920
+واحد فقط هو اللي شغال فاللي بدنا نذكره هنا أنه هذه
+
+253
+00:24:52,920 --> 00:24:57,760
+بدنا نسميه «mono-allelic expression» يعني في هذه
+
+254
+00:24:57,760 --> 00:25:04,300
+الخلية الـ DNA الـ RNA أو الناتج اللي هو نتيجة الـ
+
+255
+00:25:04,300 --> 00:25:11,780
+DNA بيكون من كوفي واحدةفمثلًا هنا في عندى بنسميه
+
+256
+00:25:11,780 --> 00:25:15,540
+«mono-allelic expression» وهنا «balanced
+
+257
+00:25:15,540 --> 00:25:18,860
+expression» يعني الأثنين بيشتركوا أنه يصير عملية
+
+258
+00:25:18,860 --> 00:25:22,620
+الـ Transcription وبعدين Translation في اللوم وفي
+
+259
+00:25:22,620 --> 00:25:25,980
+أحيانًا بيكون عندى ظواهر اللي يسمونه «allelic
+
+260
+00:25:25,980 --> 00:25:29,720
+imbalance» يعني هنا الغالبين العظمى جاي من هنا بس
+
+261
+00:25:29,720 --> 00:25:36,320
+هداك موجود بس كمية قليلة فالـ Snapsاللي موجودة في
+
+262
+00:25:36,320 --> 00:25:39,380
+الـ RNA مش عارف ليش حطوا هاي الـ SNP بالذات اللي
+
+263
+00:25:39,380 --> 00:25:44,280
+هي Single Nucleotide Polymorphism يعني الـ SNP
+
+264
+00:25:44,280 --> 00:25:49,120
+هدولة هما القاليه اللي استخدمناهم عشان نعرف أن هاي
+
+265
+00:25:49,120 --> 00:25:54,560
+أجت من هذا وهنا أجن بالنص من هنا وهنا يعني الـ SNP
+
+266
+00:25:54,560 --> 00:25:58,800
+هو Single Nucleotide Polymorphism راح نحكي عنه بعد
+
+267
+00:25:58,800 --> 00:26:06,420
+شوية فمن خلاله بقدر أعرف أني نسخةالـ DNA اللي تم
+
+268
+00:26:06,420 --> 00:26:13,540
+الـ Transcription تبعها بحيث أنه أعطاني الـ
+
+269
+00:26:13,540 --> 00:26:17,460
+RNA هذا فالفكرة
+
+270
+00:26:17,460 --> 00:26:22,220
+هنا أنه صحيح أنا عند جينين أو نسختين من الـ
+
+271
+00:26:22,220 --> 00:26:28,060
+Chromosomes ونسختين من الجينات وكذا بس مش دايماً
+
+272
+00:26:28,060 --> 00:26:32,140
+أنه أثنين لازم أثنين يشتغلوا أحياناًالإثنين
+
+273
+00:26:32,140 --> 00:26:36,860
+بيشتغلوا زي بعض تمامًا وبكون موجودين يعني مثلًا
+
+274
+00:26:36,860 --> 00:26:40,340
+الـ Hemoglobin في Alpha و Beta Chain راح ناخدها
+
+275
+00:26:40,340 --> 00:26:44,980
+الـ Beta Chain فيها نسخة واحدة واسنتين شغلتها الـ
+
+276
+00:26:44,980 --> 00:26:50,500
+Alpha Chain فيه أربعة لأنه فيه على كل كروموزوم Two
+
+277
+00:26:50,500 --> 00:26:57,220
+Alpha Chain Gen فبصير عندي أربعة مصادر ممكن أنا
+
+278
+00:26:57,220 --> 00:27:02,200
+أخد أي واحدة منهاممكن الأربع كلهم يشتغلوا ممكن بس
+
+279
+00:27:02,200 --> 00:27:05,500
+واحد اللي يشتغل ممكن أثنان يشتغلوا ممكن ثلاثة
+
+280
+00:27:05,500 --> 00:27:06,560
+يشتغلوا ممكن الأربع
+
+281
+00:27:22,930 --> 00:27:30,130
+جاية من الـ Beta
+
+282
+00:27:30,130 --> 00:27:36,010
+-Gene الأصل والـ Beta-Gene موجودة في نسكتين عندي
+
+283
+00:27:36,010 --> 00:27:43,530
+واحدة من أبوي واحدة من أمي فلما
+
+284
+00:27:43,530 --> 00:27:50,530
+نكون ندرس هذا الموضوع بشكل تفصيلي من خلالدراسة
+
+285
+00:27:50,530 --> 00:27:54,550
+الفروق الدقيقة هتكون على مستوى Single Nucleotide
+
+286
+00:27:54,550 --> 00:27:58,730
+Substitution لليه SNP؟ لليه Single Nucleotide
+
+287
+00:27:58,730 --> 00:28:02,650
+Polymerism؟ لما أستخدم هذه التقنية أني أنا أدرس
+
+288
+00:28:02,650 --> 00:28:08,350
+الجين هذا من وين أجا البروتين هل هو من الكروموزوم
+
+289
+00:28:08,350 --> 00:28:11,290
+اللي أجاني من أبوي ولا الكروموزوم اللي أجاني من
+
+290
+00:28:11,290 --> 00:28:16,730
+أمي بقدر أنا أدرس هذا الموضوع فلما أجي أدرس هذا
+
+291
+00:28:16,730 --> 00:28:24,660
+الموضوع ماشيبلاقي إن أنا عندي أكثر من احتمال في
+
+292
+00:28:24,660 --> 00:28:29,500
+حالات بتلاقي هذا الـ chromosome مثلا نفترض هذا الـ
+
+293
+00:28:29,500 --> 00:28:32,860
+chromosome اللي وردته من أبوي وكان في الجانب
+
+294
+00:28:32,860 --> 00:28:38,220
+الإفلاني يعني مثلا ناخد نفترض مثلا افتراض اللي هو
+
+295
+00:28:38,220 --> 00:28:43,520
+مثلا الـ ABO blood group راح تلاقي إن هنا الموقع
+
+296
+00:28:43,520 --> 00:28:49,220
+تبع الـ ABO blood groupوهذا الـ «جينات» الـ «جين»
+
+297
+00:28:49,220 --> 00:28:55,240
+المسؤول عن هذه الخاصية أو هذه الـ Blood Group
+
+298
+00:28:55,240 --> 00:29:00,200
+فاللي راح ألاقيه بالأخير هو أن أنا شايف الـ
+
+299
+00:29:00,200 --> 00:29:04,400
+Protein الـ Protein من أين بدي ييجي؟ بدي ييجي من
+
+300
+00:29:04,400 --> 00:29:07,880
+الـ RNA وبعدين بيعطيني الـ Protein
+
+301
+00:29:10,370 --> 00:29:15,430
+لو أنا هنا في الفتحة هذه بالضبط أنا بدرس على مستوى
+
+302
+00:29:15,430 --> 00:29:19,430
+شو صار للـ RNA يعني لسه ماكملت أني أشوف شو هو الـ
+
+303
+00:29:19,430 --> 00:29:24,850
+Protein وقفت التفاعل ووقفت الوضع المرحلة المعينة
+
+304
+00:29:24,850 --> 00:29:33,070
+ففي حالة الـ ABO System ماشي إذا واحد مثلا أخد
+
+305
+00:29:33,070 --> 00:29:41,980
+كروموزوم وعليه موقع TA من أبوهوأخد B من أمه شو
+
+306
+00:29:41,980 --> 00:29:46,060
+اللي راح يصير في جسمه راح تلاقي في الغالب Balance
+
+307
+00:29:46,060 --> 00:29:52,940
+Expression هتلاقي الـA والـB موجودة ويعني اثنان هم
+
+308
+00:29:52,940 --> 00:29:58,940
+شغلات واثنان موجودين بنفس الطريقة بنفس الكمية في
+
+309
+00:29:58,940 --> 00:30:07,480
+أوقات أو في جينات أخرى بكونفحيح عندى جينين طبعاً
+
+310
+00:30:07,480 --> 00:30:12,680
+خاصة لوسختين من نفس الجين واحياناً يعني مثلا الـ
+
+311
+00:30:12,680 --> 00:30:16,160
+Alpha Chain تبعت الـ Hemoglobin فيها Two copies
+
+312
+00:30:16,160 --> 00:30:20,640
+يعني Total يصير عندى أربع Two copies على One
+
+313
+00:30:20,640 --> 00:30:24,300
+chromosome وTwo copies على ال chromosome التاني
+
+314
+00:30:24,300 --> 00:30:29,960
+فعندي أربعولكن برغم وجود الأربعة مش الأربعة كلهم
+
+315
+00:30:29,960 --> 00:30:34,180
+شغالات لأ بيكون عندى واحد بس شغال فيه ظاهرة هي
+
+316
+00:30:34,180 --> 00:30:39,800
+بتحدث وانا هي في المناعة ندرسها ونعرفها ونفهمها
+
+317
+00:30:39,800 --> 00:30:44,560
+حتى بيسموها ان الواحد هذا لما ينجح ويشتغل ويكون هو
+
+318
+00:30:44,560 --> 00:30:48,640
+الناجح بيسكر على التانية بيسموها Allelic Exclusion
+
+319
+00:30:49,130 --> 00:30:56,490
+يعني إنه بمنع النسخ
+
+320
+00:30:56,490 --> 00:31:01,330
+الأخرى من الجينات إنها تشتغل فاحنا بنقول ما بين
+
+321
+00:31:01,330 --> 00:31:07,070
+هدولة الـ …
+
+322
+00:31:07,070 --> 00:31:13,330
+يعني ما بين هدولة الـ Two Extremes أو الـالأشياء
+
+323
+00:31:13,330 --> 00:31:18,830
+المطرفة كثير إنه 100% قد بعض إثنين أو 100% بس واحد
+
+324
+00:31:18,830 --> 00:31:24,530
+والتاني صفر يعني ما بين خمسين وخمسين وصفر ومية في
+
+325
+00:31:24,530 --> 00:31:29,630
+مرات حالات بتكون Unbalanced يعني الـ gene بيشتغل
+
+326
+00:31:29,630 --> 00:31:33,530
+ثمانين و الـ gene بيشتغل عشرين يعني هيك كلمة
+
+327
+00:31:33,530 --> 00:31:38,930
+Genomic Imprint لا والله ماني فاهمها مش هي اللي
+
+328
+00:31:38,930 --> 00:31:44,990
+مقصودة هنايعني القصد في الموضوع هذا إنه فيه آليات
+
+329
+00:31:44,990 --> 00:31:50,890
+للتحكم في الـ Transcription بحيث إنه ممكن في ظواهر
+
+330
+00:31:50,890 --> 00:31:56,090
+تكون أثنين تماماً شغلين و أثنين على أقصى سرعة
+
+331
+00:31:56,090 --> 00:32:00,950
+شغلين وأحياناً بيكون واحد بيشغل 100% والثاني صفر
+
+332
+00:32:00,950 --> 00:32:08,290
+فهذه موجودة وهدولة يعني بدنا نفهمهم كظواهريا إما
+
+333
+00:32:08,290 --> 00:32:11,330
+بكون عندي Balanced Expression، يا إما Unbalanced
+
+334
+00:32:11,330 --> 00:32:15,070
+Expression، يا إما Monoallelic Expression والـ
+
+335
+00:32:15,070 --> 00:32:19,690
+Monoallelic Expression هي الـ Parental Germline
+
+336
+00:32:19,690 --> 00:32:24,470
+Genomic Imprinting هذه حاطين Epigenetic Silencing
+
+337
+00:32:24,470 --> 00:32:29,130
+Ovaries in Imprinted Region أنا الـ Imprinting ما
+
+338
+00:32:29,130 --> 00:32:38,590
+بفهمهاش، يعني بيكون تسكير عليهمالـ Monoallelic
+
+339
+00:32:38,590 --> 00:32:44,990
+Expression في الـ T-cells والـ B-cells هو بتمن
+
+340
+00:32:44,990 --> 00:32:49,730
+خلال بعدها قضية Somatic Rearrangement اللي هي قطع
+
+341
+00:32:49,730 --> 00:32:56,230
+و لسق في الـ DNA بس هاي يعني فقط في الـ T-cells
+
+342
+00:33:01,370 --> 00:33:08,590
+مرة ثانية لما نقول «mono
+
+343
+00:33:08,590 --> 00:33:11,370
+expression» أو «balanced expression» أو
+
+344
+00:33:11,370 --> 00:33:16,910
+«imbalanced expression» التفكير الأول هيك أنه
+
+345
+00:33:16,910 --> 00:33:21,070
+الأصل أننا جينين نصف اختين منهم الأصل أنه فنتان
+
+346
+00:33:21,070 --> 00:33:26,070
+يشتغلوا وهي أحيانًا بتحدث فبتكون أنه في فنتان
+
+347
+00:33:26,070 --> 00:33:32,550
+شغلها بس أحيانًا أخرىبكون لمستوى إنه بس نسخة واحدة
+
+348
+00:33:32,550 --> 00:33:37,050
+هي اللي تشتغل يعني هنا فقط الأزرق هو الشغال الجين
+
+349
+00:33:37,050 --> 00:33:40,890
+التاني اللي موجود على الـ Chromosome الأحمر مالوش
+
+350
+00:33:40,890 --> 00:33:46,830
+أي دور أو فعلية في الجسم، في خلايا معينة، في جينات
+
+351
+00:33:46,830 --> 00:33:52,410
+محددة، في حالات معينة بتلاقي هذا الظاهر اللي بتصير
+
+352
+00:33:52,410 --> 00:33:57,190
+إنه كلها بس جين واحد، نسخة واحدة هي اللي شغالة،
+
+353
+00:33:57,190 --> 00:34:01,630
+التاني مش شغالةوأحيانًا أثنين شغلات قد بعض
+
+354
+00:34:01,630 --> 00:34:07,330
+وأحيانًا واحدة أكتر من الثانية ما أظن أنها مش صعبة
+
+355
+00:34:07,330 --> 00:34:13,970
+يعني ماشي الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+356
+00:34:13,970 --> 00:34:19,990
+الـ الـ الـ الـ
+
+357
+00:34:19,990 --> 00:34:23,670
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+358
+00:34:23,670 --> 00:34:24,830
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+359
+00:34:24,830 --> 00:34:26,430
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+360
+00:34:26,430 --> 00:34:27,450
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الوأي
+
+361
+00:34:27,450 --> 00:34:33,350
+إنسان عنده Two قليل من الممكن يعني مثلا الـ ABO
+
+362
+00:34:33,350 --> 00:34:41,610
+System فيله تلاتة قليل يا A يا B يا O وبالتالي لما
+
+363
+00:34:41,610 --> 00:34:47,630
+يكون عند إنسان AB إثنين شغلات ماشي لما يكون عنده
+
+364
+00:34:47,630 --> 00:34:52,230
+AO الـ A شغال الـ O مش شغال أصلا مافيش فيه إشي
+
+365
+00:34:52,230 --> 00:34:56,270
+يعنيفمافيش إيش ناتج منه هذا بدنا نسميه Unbalanced
+
+366
+00:34:56,270 --> 00:34:59,330
+Expression الأول اللي هو الـ Mono أقل لك إذا كان
+
+367
+00:34:59,330 --> 00:35:05,450
+AB إذا كان AO أما إن إذا الأصل AB إثنين Co
+
+368
+00:35:05,450 --> 00:35:08,750
+-dominant إثنين زي بعض بيشتغلوا فبيبين الـ A
+
+369
+00:35:08,750 --> 00:35:15,290
+وبيبين الـ B ماشي للـ X-Chromosome أنا اللي كنت
+
+370
+00:35:15,290 --> 00:35:19,350
+ناوي يعني كنت قاعد بحكي اللي هو بالنسبة للـ X
+
+371
+00:35:19,350 --> 00:35:26,070
+-Chromosome بالذاتبتلاقي أحيانًا الـ Infant الـ
+
+372
+00:35:26,070 --> 00:35:31,730
+Female اللي هي XX الأصل أنه يكون حتى لو عندها
+
+373
+00:35:31,730 --> 00:35:38,550
+Disease جين نسخة واحدة و Recessive الأصل أنها ما
+
+374
+00:35:38,550 --> 00:35:43,210
+يظهر عليها شيء لأنها Career لأن عندها ثاني شغال بس
+
+375
+00:35:43,210 --> 00:35:50,110
+حقيقة برغم أنه لو ال disease X-linked Recessive
+
+376
+00:35:50,820 --> 00:35:55,460
+بالرغم من أنه Recessive ويعني
+
+377
+00:35:55,460 --> 00:35:59,580
+الأصل بما أن أنا عنده نسخة تانية شغالة طبيعية
+
+378
+00:35:59,580 --> 00:36:05,220
+كويسة بتلاقيها بعض النساء عندهم ضواهر للمرض يعني
+
+379
+00:36:05,220 --> 00:36:12,260
+المتنحي اشتغل السبب أنه بيصير عندي Random X
+
+380
+00:36:12,260 --> 00:36:16,140
+-Chromosome Inactivation هذه ظاهرة بتحدث أنه
+
+381
+00:36:16,140 --> 00:36:21,280
+بطريقة عشوائيةالخلية بتقرر إن واحد من هالـ X
+
+382
+00:36:21,280 --> 00:36:25,600
+-Chromosomes بدنا ما نستخدموه، خلاص نستخدم واحد
+
+383
+00:36:25,600 --> 00:36:31,320
+معين طبعاً بتستخدمه لكل شيء فبقول لما نستخدمه لكل
+
+384
+00:36:31,320 --> 00:36:37,880
+شيء وكون هو المرض فيه كـ Recessive gene Recessive
+
+385
+00:36:37,880 --> 00:36:44,340
+trait، ظاهرة متنحية بتلاقيها تظهر فهي بتفسر ليش
+
+386
+00:36:44,340 --> 00:36:51,450
+أحياناً بعض الأمراضاللي حتى لو كان المرض مثنحي
+
+387
+00:36:51,450 --> 00:36:55,170
+والـ Female Carrier الأصل لأنه ما يظهر عليها شيء
+
+388
+00:36:55,170 --> 00:36:59,390
+بيتكون أنت بعض مظاهر المرض وهي تحدث في الـ Area of
+
+389
+00:36:59,390 --> 00:37:06,390
+Embryogenesis يعني هنا اللي بدي تكون تخرجه فيه أنه
+
+390
+00:37:06,390 --> 00:37:14,410
+صحيح عندي أنا كروموزومات و DNA وبنتج عنه RNAوبنتج
+
+391
+00:37:14,410 --> 00:37:36,070
+عنه بعدين بروتيل بس بس فيه نقطة
+
+392
+00:37:36,070 --> 00:37:43,570
+الأخيرة من قبل أنا على الأقلفي غالبية الجينات قد
+
+393
+00:37:43,570 --> 00:37:51,510
+تكون مثلًا نسخة واحدة فقط منها أحيانًا بعض الجينات
+
+394
+00:37:51,510 --> 00:37:57,450
+بيكون أكثر من نسخة من هذا الـGene يعني مثلًا
+
+395
+00:37:57,450 --> 00:38:01,870
+الـAlpha Chain تبع الـHemoglobin اللي مع الـBeta
+
+396
+00:38:01,870 --> 00:38:08,690
+Globin بيعطينا الـHemoglobin كاملكجين فيه له
+
+397
+00:38:08,690 --> 00:38:14,170
+نسختين على كل كروموزوم وبالتالي Total في أي خلية
+
+398
+00:38:14,170 --> 00:38:21,990
+بيكون فيه أربعة ماشي أو أحيانًا أثنين أو أقل أو
+
+399
+00:38:21,990 --> 00:38:28,590
+أكتر يعني أو أكتر فالآن دايما مش أنه دايما الأثنين
+
+400
+00:38:28,590 --> 00:38:34,520
+الأثنين بيشتغلوا زي بعض بيلاحظ أنهفيه ظواهر إن
+
+401
+00:38:34,520 --> 00:38:41,960
+الخلايا بتكون تشتغل بشكل مش متكافئ من النسختين
+
+402
+00:38:41,960 --> 00:38:46,200
+والنسختين هدولة زي ما اتفقنا بتكون واحدة من الأب
+
+403
+00:38:46,200 --> 00:38:51,760
+وواحدة من الأم ففي أحيانًا النسختين بيشتغلوا
+
+404
+00:38:51,760 --> 00:38:58,260
+تمامًا يعني مثلًا الـ AB blood group الـ locus للـ
+
+405
+00:38:58,260 --> 00:39:03,070
+blood group اللي ABO system بنسميهاللي هو على قلته
+
+406
+00:39:03,070 --> 00:39:07,470
+قليل A وB وإذا إنسان عنده A وB وواحد من الأب وواحد
+
+407
+00:39:07,470 --> 00:39:11,330
+من الأم إثنين بيشتغلوا بيشتغلوا مائة بالمائة قد
+
+408
+00:39:11,330 --> 00:39:20,810
+بعد يعني خمسين وخمسين هاي جهة وبتحدث في المقابل في
+
+409
+00:39:20,810 --> 00:39:25,870
+أحيانًا دواهر بتكون عندى ماشية في نسختين أو أربعة
+
+410
+00:39:25,870 --> 00:39:33,130
+من الـGene بس بتكون فقط ده واحد شغالةزي ما حكينا
+
+411
+00:39:33,130 --> 00:39:37,050
+في حكاية الـ Immunoglobulin الـ Immunoglobulin الـ
+
+412
+00:39:37,050 --> 00:39:41,830
+Light Chain فيه أربعة كتب للجينات بس كل B
+
+413
+00:39:41,830 --> 00:39:46,330
+-Lymphocyte بتكون بس واحدة شغالة كل البقية
+
+414
+00:39:46,330 --> 00:39:50,890
+مابيشتغلوش فبيصير هذا نوع من الـ Unbalanced
+
+415
+00:39:50,890 --> 00:39:57,630
+Expression Unbalanced Expressionما بين هدول
+
+416
+00:39:57,630 --> 00:40:05,270
+الحالات الطرفية كثيرة يعني يا أما خمسين بالمية
+
+417
+00:40:05,270 --> 00:40:10,490
+خمسين بالمية شغل يا أما صفر ومية بالمية شغل بتلاقي
+
+418
+00:40:10,490 --> 00:40:17,150
+فيه نسب تيجي بالنص ممكن من مصدر أشرين بالمية ومن
+
+419
+00:40:17,150 --> 00:40:20,870
+مصدر تمانين بالمية ممكن من مصدر سبعين بالمية ومن
+
+420
+00:40:20,870 --> 00:40:26,720
+مصدر تلاتين بالمية ففيه دايما فروقات في عمليةتشغيل
+
+421
+00:40:26,720 --> 00:40:32,800
+وتوظيف الـ DNA وهذا بيبين على مستوى الـ RNA يعني
+
+422
+00:40:32,800 --> 00:40:37,040
+أنا صحيح إن سكتين موجودات على مستوى الـ DNA بس مش
+
+423
+00:40:37,040 --> 00:40:40,940
+بالضرورة أثنانهم يشتغلوا وهذا تتدخل في دواهر زي
+
+424
+00:40:40,940 --> 00:40:46,620
+الـ Ionization اللي هو الـ X-linked deactivation
+
+425
+00:40:46,620 --> 00:40:50,860
+أو اللي حكينا عنها اللي بيصير بالنسبة للـ females
+
+426
+00:40:50,860 --> 00:40:55,560
+بعض خلايا الـ females وشرحناها والثاني
+
+427
+00:41:10,310 --> 00:41:17,250
+الآن اللي بنتكلم عنه حتى الواحد يعني يفهم تحفيظ
+
+428
+00:41:17,250 --> 00:41:25,750
+هذا الموضوع مش غلط يعني حتى يفهم كيف البشرية يعني
+
+429
+00:41:25,750 --> 00:41:31,180
+أفضلبدرجة بصعوبة كبيرة استطعنا نعرف نقرأ التسعة
+
+430
+00:41:31,180 --> 00:41:40,860
+مليارات حرف تبع الـ DNA وصوّناها الآن الإنسان أو
+
+431
+00:41:40,860 --> 00:41:48,100
+العالم أو الطبيب أو الباحث أو كده بإمكانه أنه يعني
+
+432
+00:41:48,100 --> 00:41:54,760
+يدرس أي جيل ويكون عندنا reference المرجع الأساسي
+
+433
+00:41:55,280 --> 00:41:59,060
+أستفيد منه من خلاله عشان أفهم شو الاختلافات
+
+434
+00:41:59,060 --> 00:42:06,200
+بتذكروا أنه الـ Human Genome Project اللي بدناه
+
+435
+00:42:06,200 --> 00:42:14,520
+كان أنه درسنا الـ DNA تبع إنسان معين فحتى يعني
+
+436
+00:42:14,520 --> 00:42:19,520
+الواحد يعرف يتعامل مع هذه الجوانب كلها لازم يكون
+
+437
+00:42:19,520 --> 00:42:23,200
+عنده آلية لـ
+
+438
+00:42:25,040 --> 00:42:30,460
+لاستفادة من المعلومات اللي بتيجي من دراسات الـ
+
+439
+00:42:30,460 --> 00:42:36,820
+Sequencing اللي هو عملية يعني قراءة الـ
+
+440
+00:42:36,820 --> 00:42:41,280
+Nucleotides على مستوى الـ DNA أو الـ RNA أو
+
+441
+00:42:41,280 --> 00:42:48,760
+البروتين حتى واحنا دايماً يعني هذا الجانب هنا بعض
+
+442
+00:42:48,760 --> 00:42:55,580
+المراجع من مصادر مختلفة الأصل لما واحديقوم مثلًا
+
+443
+00:42:55,580 --> 00:42:59,780
+عنده شاف عائل مريض أو درس الـ Sequence تبعها أو
+
+444
+00:42:59,780 --> 00:43:05,380
+كان إنسان مريض عنده جانب معين وأجى درسله الموضوع
+
+445
+00:43:05,380 --> 00:43:09,540
+هذا النقاط
+
+446
+00:43:09,540 --> 00:43:16,800
+هذه بتكون من خلال إنك أنت اللي طلعته من الإنسان
+
+447
+00:43:16,800 --> 00:43:22,280
+هذا أو من المريض هذا أو من العائل المريضة هذهأقوم
+
+448
+00:43:22,280 --> 00:43:30,080
+وأشوف شو هي الـ References للقطع هذه، شو بيحكوا
+
+449
+00:43:30,080 --> 00:43:35,480
+الموجود ففي الـ Human Genome Project في الـ
+
+450
+00:43:35,480 --> 00:43:39,420
+Database تبعت الـ SNPs اللي هو Single Nucleotide
+
+451
+00:43:39,420 --> 00:43:46,220
+Polymorphism اللي هو يعني أنه جزء من الموضوعقضية
+
+452
+00:43:46,220 --> 00:43:52,100
+إنه اللي صرفوا على كثير من الأبحاث بالذات اللي مش
+
+453
+00:43:52,100 --> 00:43:59,200
+بشكل تجاري زي الحكومات أو الجامعات أو كده بتلاقيهم
+
+454
+00:43:59,200 --> 00:44:03,520
+بتطلبوا إنه هذه المعلومة تكون مشاركة مع الجميع
+
+455
+00:44:03,520 --> 00:44:08,620
+يعني ما يكون هي ملك فقط للباحث بحيث يخبّي عليها
+
+456
+00:44:08,620 --> 00:44:14,240
+ومايعطيها لحد تاني فبطلبوا إنه كل الناس تشارك في
+
+457
+00:44:14,240 --> 00:44:20,340
+إنه تحطالترتيب الـ Nucleotides اللي طلعتها وترتيب
+
+458
+00:44:20,340 --> 00:44:24,800
+الـ Amino Acids والبروتين اللي طلعوا والـ RNA اللي
+
+459
+00:44:24,800 --> 00:44:30,940
+طلعوا فأهم مرجع للمصادر العلمية الآن إذا واحد بده
+
+460
+00:44:30,940 --> 00:44:36,040
+يدرس أي موضوع تعرفه اللي هو الـ PubMedالـ PubMed
+
+461
+00:44:36,040 --> 00:44:42,520
+موضع في ولايات المتحدة الأمريكية ومحطين فيه الـ
+
+462
+00:44:42,520 --> 00:44:51,200
+DNA والـ RNA والبروتين وكذا ويعني نتذكر يعني من
+
+463
+00:44:51,200 --> 00:44:56,380
+سبب أنه في عندي 64 من الـ Nucleotide Sequence حتى
+
+464
+00:44:56,380 --> 00:45:01,680
+يعمل الـ 20 Mino Acids لإنه فيه اشتراكات يعني
+
+465
+00:45:01,680 --> 00:45:07,340
+أحيانًا الـ SNAP هذهمالهاش قيمة، ما هي بتساعدنا أن
+
+466
+00:45:07,340 --> 00:45:12,240
+نشوف من وين أجى هذا الـ DNA من الأب، من الأم، هل
+
+467
+00:45:12,240 --> 00:45:16,760
+صار فيه تغير معين ولا لأ، أو أنه بس على مستوى الـ
+
+468
+00:45:16,760 --> 00:45:22,200
+Protein قد لا يكون له قيمة يعني، فهنا مجموعة مراجع
+
+469
+00:45:22,200 --> 00:45:27,960
+حتى الواحد لو طلع إشي يشوف بشبه إيش حد اكتشفه من
+
+470
+00:45:27,960 --> 00:45:32,340
+قبل، وأحيانًا هذه المراجع مش بس للـ Human Genetic
+
+471
+00:45:32,340 --> 00:45:38,500
+Diversityفي أول Whole-Genome Sequencing كان لذبابة
+
+472
+00:45:38,500 --> 00:45:43,940
+الفاكهة أو لحيوانات أخرى أو الـ بيروسات والبكتيريا
+
+473
+00:45:43,940 --> 00:45:51,340
+والنباتات وكذا ففي قواعد بيانات الـ Databases
+
+474
+00:45:51,340 --> 00:45:56,820
+بيكون فيها كل المعلومات الوراثية لكل المُركّبات
+
+475
+00:45:56,820 --> 00:46:02,820
+اللي نعرف عنها سواء Human وNon-Human وبالتالتبس
+
+476
+00:46:02,820 --> 00:46:07,300
+إحنا لما نيجي نتعامل إنه أنا والله عندى عائلة
+
+477
+00:46:07,300 --> 00:46:13,600
+مريضة أخدت الـ DNA منهم درست شو الترتيب الـ
+
+478
+00:46:13,600 --> 00:46:18,360
+Sequence سبعتهم فوق الـ PCR وعرفت الترتيب ممكن
+
+479
+00:46:18,360 --> 00:46:25,100
+أقارنه بـ Database يعنيلما نقول Diversity
+
+480
+00:46:25,100 --> 00:46:31,720
+وVariation بنبدأ بإنه في أشياء شائعة منهم مثلًا
+
+481
+00:46:31,720 --> 00:46:36,320
+اللي هي SNP اللي هي Single Nucleotide Polymorphism
+
+482
+00:46:36,320 --> 00:46:43,800
+يعني إنه بس حرف واحد على مستوى الـ DNA وكل ثلاث
+
+483
+00:46:43,800 --> 00:46:48,840
+أحرف تعطينا أمينو أسد واحد فـ Single Nucleotide
+
+484
+00:46:51,050 --> 00:46:56,530
+وPolymorphism تغيير بس واحد من الـ Base Pair وهذا
+
+485
+00:46:56,530 --> 00:47:02,430
+عادةً ممكن مايكونش له قيمة بس ممكن يكون عندي ظاهرة
+
+486
+00:47:02,430 --> 00:47:08,370
+أكتر من الـ Base Pair واحد لحد مية نسميه Insertion
+
+487
+00:47:08,370 --> 00:47:13,790
+وDeletion أحيانًا فيه Copy Number Variation يعني
+
+488
+00:47:13,790 --> 00:47:20,370
+قضية راح ناخد مثلًا بالهيموفيلياعبارة عن إذا في
+
+489
+00:47:20,370 --> 00:47:24,910
+هيموفيليا اللي أخذ الـ «ثلاثيميا» في Alpha و Beta
+
+490
+00:47:24,910 --> 00:47:28,730
+إذا تبعات الـ Alpha هي Copy Number Variation
+
+491
+00:47:28,730 --> 00:47:35,750
+فبتلاقي قطعة كبيرة أكبر من يعني عشر تلاف Base عشر
+
+492
+00:47:35,750 --> 00:47:40,710
+تلاف كيلو Base أو مليون One Mega Base أو قضية إنه
+
+493
+00:47:40,710 --> 00:47:46,630
+يصير Inversion يعني إنه نتيجة لفة الـ DNA إن حطت
+
+494
+00:47:46,630 --> 00:47:53,060
+طريقة مختلفةهي أنواع الـ Variations اللي ممكن مرات
+
+495
+00:47:53,060 --> 00:48:01,440
+تحدث هي تشبه من اللي حاطنناها مرة من قبل أنه هي
+
+496
+00:48:01,440 --> 00:48:06,920
+عندي Different Sequence في قطعة معينة بشتغل عليها
+
+497
+00:48:06,920 --> 00:48:11,580
+إذا كان زي هيك هذا الإنسان عنده القليل الأول
+
+498
+00:48:11,580 --> 00:48:17,830
+والثانيالأليلين زي بعض بس في واحد هذا عنده Snaps
+
+499
+00:48:17,830 --> 00:48:24,810
+هاي بدنا نسميها هنا اللي هي deletion أو insertion
+
+500
+00:48:24,810 --> 00:48:32,230
+هنا اللي بنلاحظه شوفوا هدولة هذا الأليل الأول اللي
+
+501
+00:48:32,230 --> 00:48:35,710
+هو بيشبه ال reference اللي صار هنا صار عندي
+
+502
+00:48:35,710 --> 00:48:42,030
+insertion يعني هاي أجت الزيادة فالـ Tكانت هنا
+
+503
+00:48:42,030 --> 00:48:49,510
+مفروض تجيب ورا الـ G ثم A ثم A ثم C ثم T ثم كده
+
+504
+00:48:49,510 --> 00:48:57,770
+فهذا النوع بدنا نسميه Indel صحيح A بس هو حقيقة هو
+
+505
+00:48:57,770 --> 00:49:02,650
+insertion single nucleotide طبعا هذا بيخرّب الدنيا
+
+506
+00:49:02,650 --> 00:49:08,220
+الـ SNP في الغادر ما راح يعمل أي شيء لأنهيمكن مرات
+
+507
+00:49:08,220 --> 00:49:12,000
+كثيرة أنه بتكون نفس البروتين بالتالي مش ضروري أن
+
+508
+00:49:12,000 --> 00:49:17,120
+يكون له تأثير بس أحياناً طبعاً بيأثر هنا هذا
+
+509
+00:49:17,120 --> 00:49:23,320
+بيسموه لما يكون insertion لواحد راح يخرّب كل ال
+
+510
+00:49:23,320 --> 00:49:29,080
+copy هذه راح تكون لأنه نقرأ ثلاث ثلاث ثلاث لما تحط
+
+511
+00:49:29,080 --> 00:49:33,840
+واحد زيادة راح تخرّب الثلاثيات أما لو صارالـ
+
+512
+00:49:33,840 --> 00:49:37,260
+insertion لثلاثة ممكن ما يكونش إيها تأثير كبير
+
+513
+00:49:37,260 --> 00:49:41,640
+لأنه بالأخير بيظل البروتين ممكن انتاجه من هذا الـ
+
+514
+00:49:41,640 --> 00:49:48,240
+DNA هنا صار عملية deletion،
+
+515
+00:49:48,240 --> 00:49:52,360
+deletion لإثنين لما يكون إثنين الـ deleted يعني
+
+516
+00:49:52,360 --> 00:49:57,300
+أنا هنا هاي تمام زي البقية هذولة الـ T والـ T طال
+
+517
+00:49:57,300 --> 00:50:03,520
+الـ C صارت تشبك ورا الـ T والبقية بنزل زي ما هو
+
+518
+00:50:04,370 --> 00:50:08,090
+فالأصل كان يعني عملوا زي هنا الـ Rectare Deletion
+
+519
+00:50:08,090 --> 00:50:13,770
+حطوا هاي ورا هاي على طول وجرّوا البقية فهذه أنواع
+
+520
+00:50:13,770 --> 00:50:22,570
+من بعض الـ Polymorphisms اللي بنشوفها فالـ
+
+521
+00:50:22,570 --> 00:50:25,750
+غير
+
+522
+00:50:25,750 --> 00:50:30,050
+الـ SNP حكينا
+
+523
+00:50:30,050 --> 00:50:36,140
+Single أو Limited يا إماinsertion أو deletion
+
+524
+00:50:36,140 --> 00:50:42,380
+أحياناً هنا copy number variant يعني أنا هنا FG
+
+525
+00:50:42,380 --> 00:50:50,740
+مرة واحدة قطيت FG FG FG طبعاً هنا يعني على مستوى
+
+526
+00:50:50,740 --> 00:51:02,000
+الجينات كلها ناشي يعني أنا بدل القليل الأولالـ «H»
+
+527
+00:51:02,000 --> 00:51:05,860
+هنا وبعدين «G» «F» يعني «A» «B» «C» «D» «E» «F»
+
+528
+00:51:05,860 --> 00:51:12,860
+«G» هذا على مستوى الجين كله فأحياناً في إنسان غير
+
+529
+00:51:12,860 --> 00:51:18,100
+إنسان ثاني إنه هنا بيصير ثلاثي copy بدل ما هي واحد
+
+530
+00:51:18,100 --> 00:51:23,600
+اللي كان لازم تكون وفي inverse polymorphism إذا
+
+531
+00:51:23,600 --> 00:51:28,220
+كان عندي مثلا ترتيب الجينات «A» «B» «C» «D» «E»
+
+532
+00:51:28,220 --> 00:51:33,200
+«F» «G» «H» كدهصار قطع ولسف بطريقة غلط بحيث أنه
+
+533
+00:51:33,200 --> 00:51:39,020
+صار AB بعدين EDC هنا الله عليه يعلم يعني مايكونش
+
+534
+00:51:39,020 --> 00:51:43,780
+تأثير كبير على الوظيفة بقدر ما أنه على مستوى الـ
+
+535
+00:51:43,780 --> 00:51:47,880
+DNA فيه اختلافات، Polymorphism Micro-satellite
+
+536
+00:51:47,880 --> 00:51:52,680
+polymorphism هي تكرار
+
+537
+00:51:52,680 --> 00:51:56,180
+لمجموعات معينة وMobile element insertion
+
+538
+00:51:56,180 --> 00:52:01,540
+polymorphismبغيّر تفتيح خيفقرات الـ DNA وأشياء
+
+539
+00:52:01,540 --> 00:52:06,000
+مختلفة فيه
+
+540
+00:52:06,000 --> 00:52:12,280
+يعني هذه الظواهر اليوم بنوقف لهذه اللحظة أنا آسف
+
+541
+00:52:12,280 --> 00:52:18,660
+اليوم خربطة من عندي بس إن شاء الله المرة اللي جاي
+
+542
+00:52:18,660 --> 00:52:22,340
+بنراجع الأشياء وده فيه أسئلة وجروب الـ WhatsApp
+
+543
+00:52:22,340 --> 00:52:25,480
+فاتحة يعني
+
+544
+00:52:27,390 --> 00:52:32,210
+إذا حد عنده أسئلة ممكن نتناقش فيها يعطيكم العافية
+
+545
+00:52:32,210 --> 00:52:37,270
+السلام عليكم السلام ورحمة الله يعطيك العافية مش
+
+546
+00:52:37,270 --> 00:52:39,770
+عارف إذا دكتورة ده كنت سامعني لأ لكن عموما يعطيك
+
+547
+00:52:39,770 --> 00:52:43,650
+العافية يعطيكم العافية يا دكاترا وإن شاء الله يعني
+
+548
+00:52:43,650 --> 00:52:47,270
+إلى لقاءة قادمة بإذن الله السلام عليكم يعطيكم
+
+549
+00:52:47,270 --> 00:52:47,650
+العافية
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/mDsVoXEA6Pk.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/mDsVoXEA6Pk.srt
new file mode 100644
index 0000000000000000000000000000000000000000..7bb6eaab1f12098d2444dc267cc356f162de5cf7
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/mDsVoXEA6Pk.srt
@@ -0,0 +1,3023 @@
+1
+00:00:00,000 --> 00:00:05,140
+أو في خلايا الإنسان واللي بتحكم في الوراثة من خلال
+
+2
+00:00:05,140 --> 00:00:11,920
+تحكمها في تكوين البروتين وشرحنا الأسس اللي عليها
+
+3
+00:00:11,920 --> 00:00:16,920
+تغيرات الـ DNA والجينات بتأدي لتغير الصفات
+
+4
+00:00:16,920 --> 00:00:23,980
+الوراثية، بس كمان يعني اللي هو بدأنا نُظهره أو بدأنا
+
+5
+00:00:23,980 --> 00:00:32,160
+نتكلم عنه، اللي هو إنه هناك آليات للتحكم في ماذا يتم
+
+6
+00:00:32,160 --> 00:00:37,780
+نسخه، أو كمية نسخه، أو من أي مكان، كيفية نسخه من الـ
+
+7
+00:00:37,780 --> 00:00:43,360
+DNA، Transcription للـ RNA، فيه هناك آليات كمان
+
+8
+00:00:43,360 --> 00:00:54,340
+يتم يعني تفعيلها بحيث إنها تتم وتكون تُؤثر أيضًا
+
+9
+00:00:55,490 --> 00:00:59,570
+فالمحصلة النهائية المظهرية عند أي إنسان هي ما
+
+10
+00:00:59,570 --> 00:01:04,030
+نسميه الـ Phenotype، اللي هي المظهر كيف راح يكون
+
+11
+00:01:04,030 --> 00:01:11,110
+وهو المسئول عنه أولاً الـ Genotype، اللي هو ما هي
+
+12
+00:01:11,110 --> 00:01:19,130
+الجينات المحددة اللي تمتلكها الخلايا، ولكن أيضاً
+
+13
+00:01:19,130 --> 00:01:21,990
+كيف بتتم التحكم
+
+14
+00:01:23,060 --> 00:01:26,800
+أحيانًا تنشيط، أو أحيانًا تثبيت هذه الجينات، فهذا
+
+15
+00:01:26,800 --> 00:01:33,940
+كان ملخص المحاضرات السابقة، اليوم بدنا نتكلم عن
+
+16
+00:01:33,940 --> 00:01:42,220
+درجة تعقيد الجينات اللي موجودة عند بني آدمين
+
+17
+00:01:42,220 --> 00:01:50,200
+وهنا إحنا بدنا نرجع لدرجة الاختلاف بين البشر
+
+18
+00:01:50,200 --> 00:01:56,770
+عمومًا، يعني ما نتكلم على شخص واحد، إحنا بنتكلم على
+
+19
+00:01:56,770 --> 00:02:03,010
+ظواهر يعني حتى يتم تقييمها أو حتى معرفتها
+
+20
+00:02:03,010 --> 00:02:10,390
+الواحد بده هيك يدرس كيف عموم الناس، فالـ Chapter 4
+
+21
+00:02:10,390 --> 00:02:15,810
+is about human genetic diversities, mutations and
+
+22
+00:02:15,810 --> 00:02:22,580
+polymorphisms، التغيرات الظاهرية أو التغيرات الشكلية
+
+23
+00:02:22,580 --> 00:02:31,740
+النقطة الأولى، يعني بالنسبة لموضوع زي هذا، بده
+
+24
+00:02:31,740 --> 00:02:41,360
+الواحد أولاً يعني يكون على قدرة على أنه يصل إلى، زي
+
+25
+00:02:41,360 --> 00:02:47,300
+ما بيقولوا، المصدر، يصل إلى الأساس، من وين، شو هو
+
+26
+00:02:47,300 --> 00:02:50,720
+الأساس اللي بتعتمد عليه، حتى تفهم أي شيء، مرات
+
+27
+00:02:50,720 --> 00:02:53,460
+كثيرة، بدك تكون فاهم من وين الأساس أجا.
+
+28
+00:02:56,500 --> 00:03:04,560
+فبصراحة، كطب سريري، بالذات إذا الواحد، وجزء كبير،
+
+29
+00:03:04,560 --> 00:03:11,580
+يعني عدد كبير من الحالات، بتكون بنسميها وراثة
+
+30
+00:03:11,580 --> 00:03:17,360
+مندلية، أو وراثة بتعتمد على اختلاف الـ Gene واحد
+
+31
+00:03:17,360 --> 00:03:23,100
+اللي هي الـ  فيه عندنا إذا الواحد بروح الـ PubMed
+
+32
+00:03:23,870 --> 00:03:30,050
+وهو موقع مشهور وكبير ومجاني
+
+33
+00:03:30,050 --> 00:03:37,070
+الـ PubMed بتلاقي فيه أولاً الـ Online Mendelian
+
+34
+00:03:37,070 --> 00:03:41,430
+Inheritance، يعني
+
+35
+00:03:41,430 --> 00:03:50,710
+الـ Depository، أو اللي هو المرجع، الـ PubMed اللي هو
+
+36
+00:03:50,710 --> 00:03:58,090
+بيشرح لك إذا شكيت فيه إنه مرض منديلي، وعندك يعني
+
+37
+00:03:58,090 --> 00:04:02,070
+رغبة إنك تفهم عنه أكثر، وإين بالضبط المشكلة أنه
+
+38
+00:04:02,070 --> 00:04:07,410
+جين، شو صار، كيف أنواعه، كيف كده، فالـ PubMed هو
+
+39
+00:04:07,410 --> 00:04:18,540
+المرجع المناسب، الآن أفرض أنا عندي عائلة أو شخص عنده
+
+40
+00:04:18,540 --> 00:04:24,960
+طفرة، أو عنده حالة أو مرض، وشكيت إنه وراثي من
+
+41
+00:04:24,960 --> 00:04:30,820
+الأشياء المطلوبة إن أنا آخذ الـ DNA تبعه، وإذا كنت
+
+42
+00:04:30,820 --> 00:04:35,180
+بعرف، راح نحكي عنها بتفاصيل أكثر بعدين، إذا كنت
+
+43
+00:04:35,180 --> 00:04:41,320
+بعرف وين الخلل في أي جين، ممكن أروح أدرس نفس الجين،
+
+44
+00:04:41,320 --> 00:04:47,080
+هو أنا بسهّل عليّ كثير، بدل ما أدرس الـ 25 ألف جين
+
+45
+00:04:47,080 --> 00:04:53,340
+صعب وطويل كثير، والآن صحيح صارت أسهل القضية اللي
+
+46
+00:04:53,340 --> 00:04:59,230
+هو نفس مبدأ الـ Human Genome Project، فأنا إذا بقدر
+
+47
+00:04:59,230 --> 00:05:07,690
+بروح بشوف قطعة مثلًا معينة وبدرسها، وراح نأخذ أمثلة
+
+48
+00:05:07,690 --> 00:05:13,550
+على ذلك، إنه أحيانًا أنا بستطيع أركز وين الخلل
+
+49
+00:05:13,550 --> 00:05:21,110
+المحتمل يكون، إذا عندي مثلًا عائلة فيها الأب والأم
+
+50
+00:05:21,110 --> 00:05:25,290
+والأخوة، بعضهم مصابين، بعضهم غير مصابين
+
+51
+00:05:25,970 --> 00:05:32,650
+فبعدين بدرس بشكل أوسع شوية، يعني ما بعمل PCR لـ
+
+52
+00:05:32,650 --> 00:05:37,610
+Individual، أو لكل الـ Sequencing، لكل الأشياء، بعمل
+
+53
+00:05:37,610 --> 00:05:42,590
+لقطعة اللي بظن فيها مشكلة، وهي بتكون إنه أنا إذا
+
+54
+00:05:42,590 --> 00:05:48,050
+عندي أكثر من شخص، بعضهم مصابين، بعضهم غير مصابين
+
+55
+00:05:48,050 --> 00:05:52,810
+فلما أنا أقارن بين المجموعتين، ممكن أحدد إنه نتيجة
+
+56
+00:05:52,810 --> 00:05:56,730
+ذلك، إنه في جيل معين هو اللي فيه المشكلة، فأفرض أنا
+
+57
+00:05:56,730 --> 00:06:03,170
+حصلت على هذا الـ Gene، ناشي، وأنا بقدر، يمكن هذا غير
+
+58
+00:06:03,170 --> 00:06:07,010
+معروف عند أي أحد في العالم، وأنا بكون بقارن بين اللي
+
+59
+00:06:07,010 --> 00:06:12,370
+مصابين وغير مصابين في المجموعة التابعة لي، بس نفترض إن
+
+60
+00:06:12,370 --> 00:06:22,120
+أنا بحاجة، أو بدي، أو أرغب إني أعمل مقارنة لما أعتبره
+
+61
+00:06:22,120 --> 00:06:25,700
+هو الإنسان السليم، أو الإنسان المرجعي، أو الإنسان
+
+62
+00:06:25,700 --> 00:06:33,720
+الأساسي، فهناك عدة يعني مراجع مفيدة ومهمة، وكثير
+
+63
+00:06:33,720 --> 00:06:37,860
+منها مجاني، يعني إذا احتاج الواحد يشتغل هذا الشغل
+
+64
+00:06:37,860 --> 00:06:44,720
+وبحاجة إلى إنه يقارن بشيء مختلف، ففي هذه مجموعة
+
+65
+00:06:44,720 --> 00:06:49,520
+مراجع، الـ Human Genome Project اللي هو أوسع واحد
+
+66
+00:06:49,520 --> 00:06:58,060
+وأول واحد، من 2003 بدأ يكون موجود، وتقريبًا كامل لكل
+
+67
+00:06:58,060 --> 00:07:05,920
+المادة الوراثية تبع بني آدم، يُعتبر أنه سليم، فإحنا
+
+68
+00:07:05,920 --> 00:07:10,560
+نأخذ كيف أن هذا الكلام يعني مش مئة بالمئة دقيق
+
+69
+00:07:10,560 --> 00:07:16,250
+بقدر ما أنه متاح، وممكن لما أنا ألاقي قطعة معينة
+
+70
+00:07:16,250 --> 00:07:20,990
+فيها خلل أو فيها تغير بطريقة معينة، أسير أدور إنه
+
+71
+00:07:20,990 --> 00:07:26,910
+ممكن هذا اللي يكون الـ... الـ... الأقل ويكون مفيد يعني
+
+72
+00:07:26,910 --> 00:07:32,680
+اللي هقارن فيه، فالـ "Human Genome Project" ممكن من
+
+73
+00:07:32,680 --> 00:07:40,900
+أول المشاريع، بس فيه كمان ناس بيحاولوا يجمعوا كمان
+
+74
+00:07:40,900 --> 00:07:47,020
+قواعد بيانات عن الاختلالات الموجودة، أو الطفرات
+
+75
+00:07:47,020 --> 00:07:51,890
+الموجودة، أو الـ Polymorphism الموجودة، فهي أنه تستطيع
+
+76
+00:07:51,890 --> 00:07:56,970
+الواحد يستفيد منها في قضية تقييم إذا كان هناك طفرة
+
+77
+00:07:56,970 --> 00:08:02,150
+معينة رأيناها إنها غير معلومة أو معلومة من قبل، أو
+
+78
+00:08:02,150 --> 00:08:07,150
+ما هو معروف عنها، أو ما هو مش معروف عنها، فهذه يعني
+
+79
+00:08:07,150 --> 00:08:14,510
+مراجع لعامة الناس لا تفيد يعني، إنما إذا واحد منكم
+
+80
+00:08:14,510 --> 00:08:18,970
+إن شاء الله في المستقبل، كان يكون عنده مختبر، وعنده
+
+81
+00:08:18,970 --> 00:08:22,630
+إمكانية، أو عنده عائلة عندها مشكلة، وبيحب يدرسها
+
+82
+00:08:22,630 --> 00:08:27,850
+بشكل أدق، حتى يصف كيف نوعية أنماط الاختلالات
+
+83
+00:08:27,850 --> 00:08:33,810
+الموجودة عندنا، فهذه المراجع هذه مهمة، وبذكركم كمان
+
+84
+00:08:33,810 --> 00:08:38,950
+إن الـ PubMed هذا، إذا الواحد دخل فيه تحت غير الـ
+
+85
+00:08:38,950 --> 00:08:44,470
+Online Mendelian Database اللي حكينا عنها، بتقدر
+
+86
+00:08:44,470 --> 00:08:49,650
+بيحط لك الـ DNA Sequence، الـ RNA Sequence، الـ
+
+87
+00:08:49,650 --> 00:08:56,430
+Protein Sequence، وبحط المراجع هناك لكل الكائنات
+
+88
+00:08:56,430 --> 00:09:03,470
+الحية، يعني مش بس الإنسانية، يعني إذا في المناعة لأنني
+
+89
+00:09:03,470 --> 00:09:07,850
+متخصص فيها، اللي بتسمعه بالـ Toll-like receptors
+
+90
+00:09:07,850 --> 00:09:13,470
+اللي هي تُستخدم في المناعة لـ مثلًا التعرف على
+
+91
+00:09:13,470 --> 00:09:19,180
+الجراثيم، هي حقيقة موجودة بالذبابة، ولأ، لما لاحظوا
+
+92
+00:09:19,180 --> 00:09:22,280
+أن الـ Sequence اللي في الإنسان في هذا المكان
+
+93
+00:09:22,280 --> 00:09:27,160
+مشابه لشيء معين موجود في الذبابة، في الـ DNA والـ
+
+94
+00:09:27,160 --> 00:09:33,220
+Sequence تبع الـ DNA وكذا، إيش اسمه؟ كانت القضية
+
+95
+00:09:33,220 --> 00:09:42,850
+مفيدة ومنبهة لإحتمالية وجود آليات معينة، النقطة
+
+96
+00:09:42,850 --> 00:09:47,130
+الأخيرة، لما نقول إنه في الـ databases فيه أشياء
+
+97
+00:09:47,130 --> 00:09:51,610
+على مستوى الـ DNA، على مستوى الـ RNA، وعلى مستوى
+
+98
+00:09:51,610 --> 00:09:55,390
+البروتين، على الثلاث مستويات هذه، بدل واحد يتذكر
+
+99
+00:09:55,390 --> 00:09:59,470
+إنه، راح نحكي بعد شوية على الـ SNP اللي هو Single
+
+100
+00:09:59,470 --> 00:10:04,790
+Nucleotide Polymorphism، تغير في قاعدة نيتروجينية
+
+101
+00:10:04,790 --> 00:10:09,830
+واحدة، قد في كثير من الأحيان، أو في الغالبية، قد لا
+
+102
+00:10:09,830 --> 00:10:14,250
+يكون هناك تغيير في البروتين الناتج، فإنتهاء الشغل
+
+103
+00:10:14,250 --> 00:10:22,430
+ممكن بالأخير تكون وظيفيًا غير مؤثرة، مع إنها يمكن
+
+104
+00:10:22,870 --> 00:10:28,090
+كاختلاف على مستوى الـ DNA موجود، بس من ناحية
+
+105
+00:10:28,090 --> 00:10:34,310
+البروتين نفسه قد لا يكون هناك نتيجة، في أسئلة؟ فهذا
+
+106
+00:10:34,310 --> 00:10:43,090
+بدي إياكم في وصف درجة التعقيد، ودرجة الاختلاف بين
+
+107
+00:10:43,090 --> 00:10:51,000
+البشر، وليس في شخص واحد، ماشي، هناك مراجع متعددة ممكن
+
+108
+00:10:51,000 --> 00:10:57,500
+الاستفادة منها، في أنه نفهم التعقيد
+
+109
+00:10:57,500 --> 00:11:03,660
+للجينات والمادة الوراثية في الإنسان عمومًا، ماشي؟
+
+110
+00:11:03,660 --> 00:11:15,680
+في أسئلة؟ إذا أحد عنده سؤال، يسأله الـ
+
+111
+00:11:19,390 --> 00:11:27,430
+هناك أنواع متعددة من الطفرات، أو التغيرات، أو
+
+112
+00:11:27,430 --> 00:11:31,290
+الأشكال
+
+113
+00:11:31,290 --> 00:11:36,870
+والأنماط من التغيرات في الـ DNA، برجع بذكر مرة ثانية
+
+114
+00:11:36,870 --> 00:11:40,070
+على اعتبار أنه نعتبر اللي بدأنا فيه دراسة
+
+115
+00:11:40,070 --> 00:11:45,610
+الـ Human Genome، إنه اللي افترض أنه إنسان المرجع
+
+116
+00:11:46,370 --> 00:11:52,670
+وهذه بس نقطة حتى نبدأ نعرف كيف نقيم، فهناك أنواع
+
+117
+00:11:52,670 --> 00:11:58,010
+مختلفة من قضايا الاختلالات
+
+118
+00:11:58,010 --> 00:12:05,290
+أو التغيرات، والأشياء الرئيسية منها نضعها مثلًا في
+
+119
+00:12:05,290 --> 00:12:12,710
+أربع أشكال وأنماط، فهناك Single Nucleotide
+
+120
+00:12:12,710 --> 00:12:18,760
+Polymorphism، وهذه على One Base Pair، يعني قاعدة
+
+121
+00:12:18,760 --> 00:12:25,660
+نيتروجينية، زوج واحد فقط، منها في محل واحد بيكون فيه
+
+122
+00:12:25,660 --> 00:12:35,560
+اختلال، إنه راح يكون بدل حرف معين بيصير حرف ثاني
+
+123
+00:12:35,560 --> 00:12:44,400
+النوع الثاني هي قضية يا إما خلل في يعني عملية
+
+124
+00:12:44,400 --> 00:12:51,940
+الانقسام وبناء الـ DNA، بحيث أنه يتم يا إما حفظ أو
+
+125
+00:12:51,940 --> 0:13:00,280
+إضافة أحيانًا من يعني قاعدة نيتروجينية واحدة إلى
+
+126
+00:13:00,280 --> 00:13:07,220
+حوالي مئة، فهذول يا إما insertion عملية
+
+127
+00:13:07,220 --> 00:13:14,120
+إدخال، أو deletion عملية حذف، يُطلق عليها كلمة Endels
+
+128
+00:13:14,120 --> 00:13:21,000
+يعني Insertions أو Deletions، وبتكون ممكن تكون ما
+
+129
+00:13:21,000 --> 00:13:25,660
+بين قاعدة واحدة، يعني Single nucleotide
+
+130
+00:13:25,660 --> 00:13:28,300
+polymorphism، في الغالب اللي راح نحكي عنه، يمكن ما تُؤثّر
+
+131
+00:13:28,300 --> 00:13:33,440
+بس الـ Insertion والـ Deletion لأ، لها تأثير قوي عادة
+
+132
+00:13:33,440 --> 00:13:38,780
+وأحيانًا قد تصل إلى 100 يعني سلسلة من 100 قاعدة
+
+133
+00:13:38,780 --> 00:13:47,910
+نيتروجينية، فكان بتكون على شكل بسيط ماشي، أو إنه
+
+134
+00:13:47,910 --> 00:13:52,610
+بتكون على طريقة تكون معقدة، بتكون تُسمّى Micro
+
+135
+00:13:52,610 --> 00:13:58,530
+-satellite، يعني نابعة عن قطعة أكبر من القواعد
+
+136
+00:13:58,530 --> 00:14:05,790
+النيتروجينية التي يمكن أن تُضاف، أو أن تحدث، ماشي، ف...
+
+137
+00:14:05,790 --> 00:14:11,010
+دكتور، في سؤال من كريم بخصوص الـ... الـ... يعني آخر
+
+138
+00:14:11,010 --> 00:14:14,090
+عمود في الجدول اللي هو الـ Numbers أو الـ Number of
+
+139
+00:14:14,090 --> 00:14:17,830
+Alleles، إيش اللي بيقصد فيه هنا يعني؟ لما يجي تتكلم
+
+140
+00:14:17,830 --> 00:14:24,050
+عن سؤال، فضل. الآن، يعني هذه ظاهرة دائمًا تحدث،
+
+141
+00:14:24,050 --> 00:14:29,250
+ماشي، في Single Nucleotide Polymorphism، راح نحكي
+
+142
+00:14:29,250 --> 00:14:34,790
+حول عددها، كبير، عادة عندنا الأصلي، هذا one أليل
+
+143
+00:14:34,790 --> 00:14:38,170
+بيكون بشكل معين، واللي فيه الـ Substitution راح
+
+144
+00:14:38,170 --> 00:14:42,320
+يكون الأليل الثاني، فعادةً إحنا بنتكلم على إنه أنا
+
+145
+00:14:42,320 --> 00:14:47,140
+Two، عندي Two Alleles، Alleles اللي هو النسخ
+
+146
+00:14:47,140 --> 00:14:51,620
+الموجودة من الجين في هذا الموقع، كم شكل هي موجودة
+
+147
+00:14:51,620 --> 00:14:56,460
+فيه، يعني بنقول الـ ABO System إنه ثلاثي Alleles، يا
+
+148
+00:14:56,460 --> 00:15:01,500
+إما A، يا إما B، يا إما O، على مستوى الجين، على مستوى
+
+149
+00:15:01,500 --> 00:15:06,220
+الـ DNA، ماشي؟ فلما نكون عنده Single Nucleotide
+
+150
+00:15:06,220 --> 00:15:10,190
+Polymorphism، بقول إنه عادة في عندي Two Alleles
+
+151
+00:15:10,190 --> 00:15:16,070
+ماشي، الآن راح نيجي نأخذ يعني الأشياء، الأليل هو
+
+152
+00:15:16,070 --> 00:15:21,790
+شكل الـ Gene اللي ممكن يحل في هذا المحل، ماشي، في
+
+153
+00:15:21,790 --> 00:15:28,940
+هذا المكان من الـ DNA، لما نكون، الاختلالات يعني
+
+154
+00:15:28,940 --> 00:15:32,300
+عادةً إحنا ليش عرفنا إنه صار "deletion" أو صار
+
+155
+00:15:32,300 --> 00:15:36,260
+"insertion"، لأنه قررنا بإيش مرجعي، فبيّن معانا إن
+
+156
+00:15:36,260 --> 00:15:41,600
+هنا صار في مثلًا حذف أو إضافة، فلما يكون عندي حذف أو
+
+157
+00:15:41,600 --> 00:15:48,180
+إضافة، بيكون عندي شو اسمه نسخ ثانية، إذا كانت simple
+
+158
+00:15:48,180 --> 00:15:56,200
+فظاهرة إنه على شكل مجموعة، وممكن كذا مرة تتكرر، فإن
+
+159
+00:15:56,200 --> 00:16:02,600
+أنماط الاختلالات، أو الأليل الموجودة، كلمة أليل لازم
+
+160
+00:16:02,600 --> 00:16:07,240
+تكونوا عارفينها، يعني فاهمينها، إنه في نفس الموقع
+
+161
+00:16:07,240 --> 00:16:11,940
+إذا البروتين أو الـ... الـ... الـ... الجين إله أكثر
+
+162
+00:16:11,940 --> 00:16:17,100
+من شكل، وكلّهم بحلّوا في نفس المحل، فبتسمّوه أليل، يعني
+
+163
+00:16:17,100 --> 00:16:23,440
+مثلًا، نحكي مثلًا على الـ HLA System اللي هو تبع
+
+164
+00:16:23,440 --> 00:16:32,550
+المناعة، الـ HLA-A اللي هو فيه HLA-A، وB، وC، هدول فيه
+
+165
+00:16:32,550 --> 00:16:38,590
+خمسمائة أليل، ستمائة أليل، يعني في عموم البشر،
+
+166
+00:16:38,590 --> 00:16:44,190
+ماشي، فيه خمسمائة نوع، شكل، بس في أي إنسان بتلاقي
+
+167
+00:16:44,190 --> 00:16:48,610
+منه اثنتين، لأنه عندي أنا two copies في محل واحد
+
+168
+00:16:49,020 --> 00:16:54,000
+لما نقول أليل يعني اللي هو البديل، البدائل اللي
+
+169
+00:16:54,000 --> 00:16:57,160
+ممكن يحلوا في هذا المكان، على أكثر، على كم شكل
+
+170
+00:16:57,160 --> 00:17:03,920
+فالـ... الـ... لما تكون الـ insertion و الـ deletion
+
+171
+00:17:03,920 --> 00:17:12,160
+إذا simple، يعني عبارة عن قطعة صغيرة تم حذفها، فلأ،
+
+172
+00:17:12,160 --> 00:17:18,940
+بتكون عبارة عن نسختين، يعني ممكنات
+
+223
+00:21:48,460 --> 00:21:56,820
+بس اللي تم هو إضافة النيكليوتيد الزيادة عشان
+
+224
+00:21:56,820 --> 00:22:01,720
+هيك شايفين هذا الطرف فوق طالع لفوق، يعني الزيادة،
+
+225
+00:22:01,720 --> 00:22:07,100
+ماشي، فطبعاً هذا على كروموزوم وهذا على كروموزوم، مش
+
+226
+00:22:07,100 --> 00:22:12,320
+اثنين يعني نحكي عن مسكتين الـDNA اللي قُبال بعض،
+
+227
+00:22:12,320 --> 00:22:19,250
+أدوله ما لهم دخل ببعض، يعني مش، شو اسمه؟ يعني ما
+
+228
+00:22:19,250 --> 00:22:26,390
+بيكونوا قبال بعض يعني هيك فهنا هذا الجزء راح يمشي
+
+229
+00:22:26,390 --> 00:22:30,910
+كويس بس لما ينظر بهذه الطريقة Single nucleotide
+
+230
+00:22:30,910 --> 00:22:35,730
+insertion وعلى الـposition هذا، هذه النقطة، وما
+
+231
+00:22:35,730 --> 00:22:41,390
+بعدها كله راح يخرب، كله راح تكون قراءته مش صحيحة،
+
+232
+00:22:41,390 --> 00:22:45,630
+الثلاثيات راح تتغير كثيراً، فهذا تأثيره على هذا
+
+233
+00:22:45,630 --> 00:22:51,180
+البروتين أو على هذا الجين كارثي أو كبير جداً إذا
+
+234
+00:22:51,180 --> 00:22:57,680
+صار insertion لثلاثة nucleotides، لأ والله ممكن أن
+
+235
+00:22:57,680 --> 00:23:03,900
+تعدل الأمور وتكون الأمور مقبولة، يعني هنا تم إضافة
+
+236
+00:23:03,900 --> 00:23:09,260
+شو اسمه يعني النيكليوتيد أو nitrogenous base
+
+237
+00:23:09,260 --> 00:23:17,280
+زيادة، هنا تم حذف نسختين، فطبعاً مش راح يكون بهذا
+
+238
+00:23:17,280 --> 00:23:21,200
+الشكل، اللي راح يكون الـC راح تيجي تحت الـT والـT
+
+239
+00:23:21,200 --> 00:23:26,920
+تحت الـT وكذا، هتلاقي اللي تحتاني، الأليل الثاني، Two
+
+240
+00:23:26,920 --> 00:23:33,940
+nucleotides smaller، فهي ظواهر موجودة، وهنا إحنا
+
+241
+00:23:33,940 --> 00:23:41,560
+بنحكي عن أنه أنا قمت بدراسة الـDNA على مستوى أحرف
+
+242
+00:23:41,560 --> 00:23:48,040
+النيكليوتيدات تبعاته في قطعة معينة، وراح نحكي عنها
+
+243
+00:23:48,040 --> 00:23:54,680
+بعد شوية تفاصيل أكثر من ناحية أيش الـ الـ الـ يعني
+
+244
+00:23:54,680 --> 00:24:01,580
+الـ أيش التجارب أو أيش الأجهزة أو أيش الشيء
+
+245
+00:24:01,580 --> 00:24:07,980
+اللي بيخليني أقدر أصل لهذه النقطة، فيها أسئلة؟
+
+246
+00:24:07,980 --> 00:24:11,720
+الأول
+
+247
+00:24:12,940 --> 00:24:16,260
+في الغالب يمكن ما يكون له تأثير، أو في احتمال قليل
+
+248
+00:24:16,260 --> 00:24:19,900
+أن يكون له تأثير، الثاني والثالث اللي هم تهدرات
+
+249
+00:24:19,900 --> 00:24:23,640
+كبيرة جداً، لو كانت الـInsertion أو الـDeletion
+
+250
+00:24:23,640 --> 00:24:32,980
+لثلاث نيكليوتيدات، كان لأ، راح يصير كله كويس، حكينا،
+
+251
+00:24:32,980 --> 00:24:34,220
+فيها سؤال؟
+
+252
+00:24:39,410 --> 00:24:43,850
+حكينا أنه ممكن أن يكون عندي Copy Number Variation،
+
+253
+00:24:43,850 --> 00:24:49,650
+يعني إحنا هنا كأنو طلعنا من الـSingle
+
+254
+00:24:49,650 --> 00:24:54,950
+Nucleotide Mutations، يعني كل الأمثلة اللي حكيناها
+
+255
+00:24:54,950 --> 00:25:03,170
+هي عبارة عن، بتكون على مستوى الحرف الواحد، ممكن تكون
+
+256
+00:25:03,170 --> 00:25:11,550
+عندي اختلالات برضه على مستوى أن القطعة أكبر، فهي
+
+257
+00:25:11,550 --> 00:25:15,070
+بيسموها Micro-satellite polymorphism، يعني تكون
+
+258
+00:25:15,070 --> 00:25:19,090
+عندي قطعة أكبر، ممكن توصل إنها تكون Gene أو كذا،
+
+259
+00:25:19,090 --> 00:25:25,030
+أحياناً، يعني لو لاحظت، أنا شغلي زي هيك مثلاً، ناخد
+
+260
+00:25:25,030 --> 00:25:29,910
+هذا المثال بالأول، أنه أنا قطعة بلاقي فيها، إذا درست
+
+261
+00:25:29,910 --> 00:25:36,030
+ترتيبها، في قطع تلاقيها A B C D E F G ماشي بالترتيب،
+
+262
+00:25:36,030 --> 00:25:42,630
+A B وبعدين E D C ومن هنا F G H، شو اللي صار؟ أنه
+
+263
+00:25:42,630 --> 00:25:47,470
+هذه القطعة بالكامل انقلبت، طبعاً هذا على الأليل الأول
+
+264
+00:25:47,470 --> 00:25:51,780
+وهذا على الأليل الثاني، يعني شو هذا على كروموزوم وهذا
+
+265
+00:25:51,780 --> 00:25:55,460
+على كروموزوم، ما لهم دخل ببعض، يعني مش إحنا بنحكي
+
+266
+00:25:55,460 --> 00:26:00,240
+على نسختين اللي قبال بعض، في مرات بيصير عندي copy
+
+267
+00:26:00,240 --> 00:26:05,700
+number variation، A B C D E الـ F G بدل ما هي مرة
+
+268
+00:26:05,700 --> 00:26:13,280
+واحدة صارت F G F G F G H، فصارت ثلاث مرات، فهي بتكون
+
+269
+00:26:13,280 --> 00:26:17,160
+في اختلال معين، "Mobile element insertion
+
+270
+00:26:17,160 --> 00:26:22,460
+polymorphism"، يعني برضه قطعة إضافية دخلت بالتوجيه،
+
+271
+00:26:22,460 --> 00:26:30,360
+بتلاقيها في اختلال بينها، صارت أربعة وكأنها متحركة،
+
+272
+00:26:30,360 --> 00:26:37,190
+فهذه يعني ظواهر على مستوى بنسميها Micro-satellite،
+
+273
+00:26:37,190 --> 00:26:41,730
+يعني مش Single Nucleotide، بدها طريقة دراسة أكبر،
+
+274
+00:26:41,730 --> 00:26:48,210
+بدها يعني حتى نستطيع أن نعرف أن هاي على مستوى
+
+275
+00:26:48,210 --> 00:26:51,070
+Micro-satellite، أنا مش داخل هنا على مستوى
+
+276
+00:26:51,070 --> 00:26:53,830
+النيكليوتيدات، أنا ببدأ بالنيكليوتيدات
+
+277
+00:26:53,830 --> 00:26:58,430
+والـSequencing، وبعدين باخد قطعة بالكامل وبشوف شو
+
+278
+00:26:58,430 --> 00:27:01,250
+الاختلافات بينها، ماشي؟
+
+279
+00:27:05,680 --> 00:27:13,860
+الآن يعني أنا بفضل أن الواحد صحيح بالأخير
+
+280
+00:27:13,860 --> 00:27:17,720
+بيرسم له الرسمة هذه وبيصير
+
+281
+00:27:19,790 --> 00:27:28,070
+يعني يطلبوا منه يفهمها في دراسة أو كده، وبتكون يعني
+
+282
+00:27:28,070 --> 00:27:32,510
+أحياناً بدك تكون اشتغلت في مختبر وشفت كيف تنعمل
+
+283
+00:27:32,510 --> 00:27:39,790
+وبعدين عشان تفهم الكلام اللي ذكرته هنا، بحاول يعني
+
+284
+00:27:39,790 --> 00:27:48,750
+هي hypothetical يعني نظرية أن أنا عندي قطعة الـ
+
+285
+00:27:48,750 --> 00:27:52,910
+DNA بسوي
+
+286
+00:27:52,910 --> 00:27:59,050
+بيسموه Markers، بيسميها مرات Markers، عبارة عن يعني
+
+287
+00:27:59,050 --> 00:28:06,280
+قطعة شوية أكبر من الـDNA وإن يكون الأحرف يعني
+
+288
+00:28:06,280 --> 00:28:13,580
+بترتيب معين، يعني مثلاً نفترض إذا استخدمنا يعني أنا
+
+289
+00:28:13,580 --> 00:28:18,020
+بقول دائماً الجينات تقريباً عشان تعطي بروتينات،
+
+290
+00:28:18,020 --> 00:28:24,900
+نعتبرها زي قصيدة، ماشي، وبتلاقيك
+
+291
+00:28:24,900 --> 00:28:28,660
+لما بدك مثلاً NASA، Google بدك تدور على شيء بتحط
+
+292
+00:28:28,660 --> 00:28:37,490
+كام كلمة من بداية أو من بيت الشعر اللي بدك إياه،
+
+293
+00:28:37,490 --> 00:28:43,990
+وبدك تعرفه وتستخدمه مثلاً، يعني مثلاً باجي أنا
+
+294
+00:28:43,990 --> 00:28:50,090
+بدي أدور على قصيدة امرؤ القيس المعلقة الأولى،
+
+295
+00:28:50,090 --> 00:28:54,190
+يعني "قف أنا بكى من ذكرى يا حبيبي"، فبقول "قف أنا
+
+296
+00:28:54,190 --> 00:28:59,430
+بكي من ذكرى"، لما أنا أحط قطعة أطول شوية، مش حرف
+
+297
+00:28:59,430 --> 00:29:04,870
+واحد، أنا بحط، بحط مجموعة، كلمة "قف نبكي من ذكرى"
+
+298
+00:29:04,870 --> 00:29:09,650
+مش راح تلاقيها في كثير من القصائد، يعني هتكون شغل
+
+299
+00:29:09,650 --> 00:29:17,610
+نادر، فهي تقريباً مميزة فقط لقصيدة امرؤ القيس،
+
+300
+00:29:17,610 --> 00:29:25,510
+فبالتالي أنا أستطيع أن أدرس، وهنا بتكلم على مستوى
+
+301
+00:29:25,510 --> 00:29:32,860
+عائلي، يعني أنا جبت الأب والأم والثلاث أطفال زي ما
+
+302
+00:29:32,860 --> 00:29:42,500
+هم حاطينه هنا، وعندهم هذه الشغل، يعني دكتور، في سؤال
+
+303
+00:29:42,500 --> 00:29:48,020
+من دكتورة كارميل بخصوص اللي هو الـ "Copy number" و
+
+304
+00:29:48,020 --> 00:29:52,720
+"Microsatellite" وما هو الفرق بينهم؟ يعني الاثنين
+
+305
+00:29:52,720 --> 00:30:01,190
+في تقرير للنيكليوتيدات؟  انتبه لشغلي اللي حكينا عنهم
+
+306
+00:30:01,190 --> 00:30:06,070
+بالنسبة
+
+307
+00:30:06,070 --> 00:30:10,630
+لما نتكلم عن أنه بدي أستخدم الـMicrosatellite بدي
+
+308
+00:30:10,630 --> 00:30:16,350
+أستخدم، يعني أنا بدي أشبهها الآن باللي بحكي عنه هما
+
+309
+00:30:16,350 --> 00:30:21,450
+شغلتين، أشياء متقاربة، اللي هي قضية أن بطلنا نتكلم
+
+310
+00:30:21,450 --> 00:30:24,890
+على Single Nucleotide، يعني هذه النقطة الأولى، فإحنا
+
+311
+00:30:24,890 --> 00:30:29,510
+وأنا بنتكلم على قطعة، ماشي، قطعة قصيرة، ممكن أطول
+
+312
+00:30:29,510 --> 00:30:36,170
+شوية لحد 100 نيكليوتيد، يعني اللي هم حاطينه هنا
+
+313
+00:30:36,170 --> 00:30:43,070
+ممكن يعني، هاي اللي هي Micro-satellite لحد الـ 100
+
+314
+00:30:43,070 --> 00:30:48,290
+Base Pairs، بينما الـCopy Number Variance نحكي
+
+315
+00:30:48,290 --> 00:30:54,450
+ممكن من هنا من 10,000 لـ 1 مليون نيكليوتيد، الـ
+
+316
+00:30:54,450 --> 00:31:00,390
+Copy Number Variance برضه حاطينه على شكل شو اسمه؟
+
+317
+00:31:00,390 --> 00:31:06,270
+يعني على شكل قطعة أكبر من الـDNA، ماشي؟ فأما
+
+318
+00:31:06,270 --> 00:31:13,350
+الاثنين، في قضية ممكن زيادة العدد، يعني اللي هي
+
+319
+00:31:13,350 --> 00:31:18,110
+زيادة
+
+320
+00:31:18,110 --> 00:31:23,190
+عدد الـCopies، قصدي، فهنا هذه الأمثلة على الـ"Human
+
+321
+00:31:23,190 --> 00:31:26,830
+Genome Larger Than Snip"، يعني خلاص، تجاوزنا، أنا
+
+322
+00:31:26,830 --> 00:31:30,230
+بدأ أتكلم على هذه النقاط، بتكلم عن أن أنا بتعامل
+
+323
+00:31:30,230 --> 00:31:38,910
+مع يعني قطعة أكبر، سواء عدد قليل "Nucleotides"
+
+324
+00:31:38,910 --> 00:31:43,570
+أربعة، خمس، عشرة، لحد مئة أو حتى قطعة أكبر من
+
+325
+00:31:43,570 --> 00:31:55,520
+الـDNA، ماشي؟ فاللي بدأ أحكيه هنا أن المثال
+
+326
+00:31:55,520 --> 00:32:02,800
+هذا اسمه "Microsatellite Marker Study"، يعني عبارة
+
+327
+00:32:02,800 --> 00:32:09,700
+عن دراسة معينة، هنا بنسميها فرضية أو تخيُلية أو
+
+328
+00:32:09,700 --> 00:32:16,080
+احتمالية، تكون كذا اللي راح ألاقيه كالتالي، أنا جبت
+
+329
+00:32:16,080 --> 00:32:22,460
+Marker اللي هي زي مجموعة كلمات مرتبة بطريقة معينة،
+
+330
+00:32:22,460 --> 00:32:28,760
+زي "قف نبكي من ذكرى"، نستخدم هذه الكلمة، فهذه
+
+331
+00:32:28,760 --> 00:32:32,340
+القطعة أنا بأستفيد منها في قضية التدوير على هذا
+
+332
+00:32:32,340 --> 00:32:37,720
+الـGene اللي أنا قصدي أدور عليه، جين معين في الحالة،
+
+333
+00:32:37,720 --> 00:32:43,890
+هذه، قصيدة أبو العلاء المعري، بأجي أنا بأستخدم هذا
+
+334
+00:32:43,890 --> 00:32:51,270
+الـMarker وبدرس شو هو وضع العائلة هذه، بلاقي أن
+
+335
+00:32:51,270 --> 00:32:55,690
+مثلاً الأم، طبعاً إحنا الآن الـMarker لهذا الـ
+
+336
+00:32:55,690 --> 00:33:00,030
+Gene اللي هو للقطعة هذه، هذا اللي أنا استخدمته،
+
+337
+00:33:00,790 --> 00:33:07,150
+وبعدين بأستخدم الـMarker أن أنا أول شيء يعني زي ما
+
+338
+00:33:07,150 --> 00:33:11,910
+تقوله بكسر الـDNA بشكل معين عشان يكون قطعة أقل،
+
+339
+00:33:11,910 --> 00:33:20,370
+وبعدين بعمل Electrophoresis، يعني بخلي الـDNA،
+
+340
+00:33:20,370 --> 00:33:26,030
+القطعة الـDNA تمشي حسب الـElectrical Charge تبعها،
+
+341
+00:33:26,030 --> 00:33:32,200
+الـSystem، فإذا كانت قطعة، طبعاً بيحطوا مثلاً فوق
+
+342
+00:33:32,200 --> 00:33:39,080
+الـOrigin، وبعدين بيخلوها تمشي، فإذا كانت القطعة
+
+343
+00:33:39,080 --> 00:33:45,120
+كبيرة بتكون ثقيلة، ما بتتحرك، إذا كانت القطعة صغيرة
+
+344
+00:33:45,120 --> 00:33:53,100
+فهي خفيفة، فبتلاقيها تتحرك بشكل سريع، فالفكرة
+
+345
+00:33:53,100 --> 00:33:58,940
+هنا في طريقة الانتشار الـ الـ الـ الـ الـ الـ الـ
+
+346
+00:33:58,940 --> 00:33:59,140
+الـ الـ الـ الـ الـ الـ الـ
+
+347
+00:33:59,140 --> 00:33:59,960
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+348
+00:33:59,960 --> 00:34:00,000
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+349
+00:34:00,000 --> 00:34:10,460
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+350
+00:34:10,460 --> 00:34:10,760
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+351
+00:34:10,760 --> 00:34:13,880
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+352
+00:34:13,880 --> 00:34:19,300
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+353
+00:34:23,280 --> 00:34:28,200
+الطفل الثاني أخذ من الأب هذه القطعة وأخذ من الأم
+
+354
+00:34:28,200 --> 00:34:35,240
+القطعة الثانية، وبالنسبة للشخص الثالث فهي يعني حسب
+
+355
+00:34:35,240 --> 00:34:44,480
+أنا إذا بقدر ألاقي كيف يعني مين المصاب ومين السليم
+
+356
+00:34:44,480 --> 00:34:48,700
+في العائلة، وشو علاقة الأب بالأم، وشو نوعية متوقعة
+
+357
+00:34:48,700 --> 00:34:53,560
+تكون نوعية الوراثة، سائد، متنحي، وكذا، هذه طريقة
+
+358
+00:34:53,560 --> 00:35:00,240
+لدراسة الاختلافات الموجودة، بينما لنفس هذا الموقع،
+
+359
+00:35:00,240 --> 00:35:06,180
+لنفس هذا الجين، ماشي، لو جبت أشخاص آخرين من
+
+360
+00:35:06,180 --> 00:35:09,560
+الـPopulation، راح ألاقي لو كل واحد عنده Two
+
+361
+00:35:09,560 --> 00:35:15,100
+copies، في الغالب، بس بتكون أشكالهم مختلفة، فلما
+
+362
+00:35:15,100 --> 00:35:23,840
+نيجي نحكي هنا على، يعني كم قليل متوقع يكون موجود؟
+
+363
+00:35:23,840 --> 00:35:28,720
+يعني هذه العائلة فيها Two Alleles بس، ماشي؟ اللي
+
+364
+00:35:28,720 --> 00:35:34,660
+هم يعني، أو هنا بدأ تكون Four Alleles، ماشي؟
+
+365
+00:35:34,660 --> 00:35:38,720
+أحياناً إذا فيه Homozygous راح يطلع اثنين فوق بعض،
+
+366
+00:35:38,720 --> 00:35:42,500
+يعني راح يبين في شخص عنده نسخة واحدة بس، هنا Four
+
+367
+00:35:42,500 --> 00:35:47,060
+Alleles، بدنا نعتبر، ماشي؟ هنا الـAlleles أكثر حتى
+
+368
+00:35:47,660 --> 00:35:52,640
+في الـUnrelated Individuals، وهذه باستخدام تقنية
+
+369
+00:35:52,640 --> 00:36:00,220
+أن أنا أدرس قطع الجينوم أو قطع الـDNA بحيث
+
+370
+00:36:00,220 --> 00:36:05,820
+أن أدرسها على قضية الـ"Microsatellite"
+
+371
+00:36:05,820 --> 00:36:11,220
+variation and diversity، وبتكون هيك ظواهر بتكون
+
+372
+00:36:11,220 --> 00:36:14,640
+موجودة بين البشر، في أسئلة؟
+
+373
+00:36:23,650 --> 00:36:31,710
+بالنسبة لعلاقة الجين
+
+374
+00:36:31,710 --> 00:36:38,970
+مع الظواهر اللي حكيناها، هو برضه hypothetical، يعني
+
+375
+00:36:38,970 --> 00:36:46,460
+نظرية أو افتراضية، إذا عندي أنا هذه الأشياء الأصلية،
+
+376
+00:36:46,460 --> 00:36:53,400
+طبعاً هنا إحنا الـReference Sequence اللي أنا بدأت
+
+377
+00:36:53,400 --> 00:37:00,000
+فيه، وهنا هذول الـTwo copies تبعات الـDNA في One
+
+378
+00:37:00,000 --> 00:37:03,500
+Allele، يعني هذه الجهة واحدة، مش زي الصور اللي قبل
+
+379
+00:37:03,500 --> 00:37:09,040
+شوية كنا نحكي عن Two Alleles، فهنا إذا حكينا أن
+
+380
+00:37:09,040 --> 00:37:11,960
+أنا صار عندي Substitution Single Nucleotide
+
+381
+00:37:11,960 --> 00:37:17,730
+Polymorphism، مثلاً في المنطقة هذه بحيث أنه صار عندي
+
+382
+00:37:17,730 --> 00:37:26,210
+بدل ما هي البقية كله بالترتيب، صار هنا CGC بدل TA،
+
+383
+00:37:26,210 --> 00:37:35,550
+بهذه الطريقة، فهي ممكن تعتبر ظاهرة وهي راح يكون أن
+
+384
+00:37:35,550 --> 00:37:40,580
+كل هذا القطعة راح تغير النيكليوتيد تبعها وبالتالي
+
+385
+00:37:40,580 --> 00:37:49,780
+قد يعني تؤشر لـMinor asset ثاني، وتعمل substitution،
+
+386
+00:37:49,780 --> 00:37:55,300
+وتغير، بس أحياناً قد لا تغير، نصير عندنا deletion،
+
+387
+00:37:56,930 --> 00:38:03,990
+ماشي، ماشي، ماشي،
+
+388
+00:38:03,990 --> 00:38:07,430
+ماشي،
+
+389
+00:38:07,430 --> 00:38:13,050
+ماشي، ماشي، ماشي، ماشي، ماشي، ماشي، ماشي، ماشي،
+
+390
+00:38:13,050 --> 00:38:13,750
+ماشي، ماشي، ماشي، ماشي، ماشي، ماشي، ماشي، ماشي،
+
+391
+00:38:13,750 --> 00:38:14,670
+ماشي، ماشي، ماشي، ماشي، ماشي، ماشي، ماشي، ماشي،
+
+392
+00:38:14,670 --> 00:38:14,690
+ماشي، ماشي، ماشي، ماشي
+
+445
+00:43:19,250 --> 00:43:26,990
+فكل واحدة منهم، فهناك دراسات متعددة لنسبة
+
+446
+00:43:26,990 --> 00:43:33,950
+تواجد، نسبة حدوث، نسبة حدوث
+
+447
+00:43:33,950 --> 00:43:39,620
+التفرق بالشكل اللي بتسبب بعدين المرض، طبعًا يعني مثل
+
+448
+00:43:39,620 --> 00:43:44,740
+ما درست مثلًا بشكل معين هنا ممكن نلاقي نقول إن
+
+449
+00:43:44,740 --> 00:43:49,000
+المصاب هو المصاب يشير لي على إن الإصابة نشأت مثلًا
+
+450
+00:43:49,000 --> 00:43:55,020
+في أم على الـ X-Chromosome، بس هي لأن عندها Two
+
+451
+00:43:55,020 --> 00:43:58,820
+copies، ما صار معاها مرض وكان فقط حامل وبعدين
+
+452
+00:43:58,820 --> 00:44:05,190
+الأطفال الدكور بعضهم بيطلع عنده المرض، يعني هذه
+
+453
+00:44:05,190 --> 00:44:12,670
+كلها أشياء يتم دراستها و... إذا بدنا نأخذ الـ
+
+454
+00:44:12,670 --> 00:44:16,570
+Mendelian Inheritance، تقريبًا نتكلم على بالألاف،
+
+455
+00:44:16,570 --> 00:44:21,350
+عشرات الآلاف من الأمراض ممكن تكون هناك اختلالها
+
+456
+00:44:21,350 --> 00:44:24,810
+لما
+
+457
+00:44:24,810 --> 00:44:34,110
+ندرس الأمراض الوراثية، بنلاقي إنه إذا بقدر شو نسبة
+
+458
+00:44:34,110 --> 00:44:41,350
+حدوث نوعية معينة من الطفرات اللي تؤدي لهذه
+
+459
+00:44:41,350 --> 00:44:44,410
+الإشكالية،
+
+460
+00:44:44,410 --> 00:44:50,900
+بنلاقي إنه اللي هو بيسموه Missense Mutation، اللي
+
+461
+00:44:50,900 --> 00:44:57,040
+هي أنه يعني اللي بفهمها "Nucleotide Substitution"
+
+462
+00:44:57,040 --> 00:45:02,860
+ماشي، يعني هدول اللي هما الـ SNPs، الدرجة الأساسية
+
+463
+00:45:02,860 --> 00:45:08,940
+اللي هي أنه خمسين بالمئة من الأمراض اللي من ديالية
+
+464
+00:45:08,940 --> 00:45:13,320
+إذا بتيجي بتشوف شو نوعية المشكلة اللي عندها،
+
+465
+00:45:13,320 --> 00:45:18,680
+بتلاقي كثير منها عبارة عن Single-Nucleotide
+
+466
+00:45:18,680 --> 00:45:23,440
+Substitution، بس بيخرّب الـ Amino Acid، بيخرّب نتيجة
+
+467
+00:45:23,440 --> 00:45:28,860
+ذلك ووظيفة البروتين، وبالتالي بيصير عندك مرض، ففي
+
+468
+00:45:28,860 --> 00:45:34,880
+أحيانًا بتكون أنه الـ Single-Nucleotide
+
+469
+00:45:34,880 --> 00:45:40,700
+Substitution أدى إلى أنه اللي بيطلع هو بيقوله بدل
+
+470
+00:45:40,700 --> 00:45:48,550
+ما البروتين بيكون طويل، بيجي مقطوع نصه، ربعه، جزء منه
+
+471
+00:45:48,550 --> 00:45:53,270
+عشان كان Premature stop codon، يعني بالصدفة الـ
+
+472
+00:45:53,270 --> 00:45:59,130
+Substitution كانت نتيجتها stop، فبالتالي بوقف الـ
+
+473
+00:45:59,130 --> 00:46:03,950
+Transcription، وبالتالي بطلع البروتين ناقص، وبالتالي
+
+474
+00:46:03,950 --> 00:46:08,590
+وظيفته مش مظبوطة، في أحيانًا الـ RNA Processing
+
+475
+00:46:08,590 --> 00:46:13,100
+Mutations، يعني في أحيانًا اللي حكينا فيه Intron
+
+476
+00:46:13,100 --> 00:46:16,620
+و فيه Exon، وبدنا نلف بطريقة معينة حتى نقطعها حتى
+
+477
+00:46:16,620 --> 00:46:22,860
+نعطي الـ Messenger RNA، فأحيانًا الـ Mutation في
+
+478
+00:46:22,860 --> 00:46:30,980
+موقع خطير لهذه القضية بحيث أنه بنتج عنه أنه ما
+
+479
+00:46:30,980 --> 00:46:37,540
+بتمكن الـ RNA أن يتم نسخه لبروتين بشكل جيد وكويس،
+
+480
+00:46:38,140 --> 00:46:44,860
+فهي تقريبًا نسب الأشياء، بس الـ "سنب" صحيح راح ناخد
+
+481
+00:46:44,860 --> 00:46:49,560
+بعد شوية، هي نسبها عالية ويمكن ما تكونش الها قيمة
+
+482
+00:46:49,560 --> 00:46:53,560
+بس من الأمراض، هي تمثل خمسين بالمئة من الأشياء
+
+483
+00:46:53,560 --> 00:46:56,760
+المعروفة حاليًا بالنسبة للـ "ديليشن" والـ
+
+484
+00:46:56,760 --> 00:47:03,580
+"إنسيرشن"، برضه لو one or two، راح يكون مشكلة كبيرة،
+
+485
+00:47:03,580 --> 00:47:09,900
+فـ Deletion تمثل 25% من الأمراض الوراثية اللي
+
+486
+00:47:09,900 --> 00:47:16,400
+بنعرفها الـ Mendelian، وبتكون 25% لو كان على عدد
+
+487
+00:47:16,400 --> 00:47:22,680
+قليل، يعني one or two nucleotides أو أربعة أو خمسة،
+
+488
+00:47:22,680 --> 00:47:29,520
+المهم مش ثلاثة، ثلاثة وضِعفاته، يمكن ما يأثرش كثير إنه
+
+489
+00:47:29,520 --> 00:47:36,300
+كوظيفة بشكل كامل على البروتين، فهذه أنواع إذا بتكون
+
+490
+00:47:36,300 --> 00:47:41,460
+deletions و insertions، يعني النقطة اللي بدأ كل واحد
+
+491
+00:47:41,460 --> 00:47:46,950
+يتذكرها إنه تقريبًا من الأمراض الوراثية المندلية
+
+492
+00:47:46,950 --> 00:47:53,170
+نسبة 50% هي SNPs، Single-Nucleotide Polymorphism،
+
+493
+00:47:53,170 --> 00:47:58,070
+نتجت عنها Amino Acid Substitution، يعني صار عندي
+
+494
+00:47:58,070 --> 00:48:04,730
+تغيير في الـ Amino Acid، حيث أنه أنتج عنه المرض، في
+
+495
+00:48:04,730 --> 00:48:10,070
+أنواع أخرى، طرق أخرى، ممكن SNPs يؤدي لمشاكل، وربع، 25
+
+496
+00:48:10,070 --> 00:48:17,560
+% بتكون اللي هي بالأخير هون بيسموه "missense"، هاي
+
+497
+00:48:17,560 --> 00:48:24,720
+بتعتبروها "nonsense"، أو إنه بتخرّب الـ الـ الـ
+
+498
+00:48:24,720 --> 00:48:29,180
+DNA كقراءة، بحيث إنه ببطّل يُصنّع الـ protein اللي
+
+499
+00:48:29,180 --> 00:48:33,860
+أنا مطلوب إني أعمله، أحيانًا
+
+500
+00:48:36,190 --> 00:48:40,570
+يعني هناك طرق متعددة لكيف بيصير الـ Deletion أو
+
+501
+00:48:40,570 --> 00:48:44,490
+كيف بيصير الـ Insertion، أو كيف شو اللي بيصير عندنا،
+
+502
+00:48:44,490 --> 00:48:50,390
+وهذه أمثلة يعني جيدة،
+
+503
+00:48:50,390 --> 00:48:54,010
+الواحد يعني يكون على اطلاع عليها، أو على الأقل حتى
+
+504
+00:48:54,010 --> 00:48:59,830
+يحاول يقرأ بعدين عنها، يعني يكون مستوعب شو الكلام
+
+505
+00:48:59,830 --> 00:49:07,970
+اللي هو هنا الـ "Hemophilia"، الـ "Hemophilia"،
+
+506
+00:49:07,970 --> 00:49:14,910
+المعروف فيه على الـ X-Chromosome، فالـ X-Chromosome
+
+507
+00:49:14,910 --> 00:49:19,410
+فيه عليه الـ "Hemophilia" هو "Factor 8"، الـ "جين"،
+
+508
+00:49:19,410 --> 00:49:23,450
+وبالتالي طبعًا الـ "Hemophilia" A، لأنه فيه
+
+509
+00:49:23,450 --> 00:49:28,610
+"Hemophilia" B اللي هي "Factor 9"، مش "Factor"
+
+510
+00:49:30,860 --> 00:49:39,720
+بتلاقي هنا أنه بسبب هنا أنه الأصل أنه أنا عندي 23
+
+511
+00:49:39,720 --> 00:49:52,020
+Exon، فعندي 22 Intron بالنص، ماشي، فالنتيجة
+
+512
+00:49:52,020 --> 00:49:54,580
+يعني
+
+513
+00:49:55,340 --> 00:50:01,860
+احتمالية حدوث Loop معين في Silk أو حبل الـ DNA
+
+514
+00:50:01,860 --> 00:50:10,600
+بيصير عندي عملية اختلال في ترتيب وفي، يعني هنا صار
+
+515
+00:50:10,600 --> 00:50:19,880
+زي Loop، وقلب في ترتيب الـ Introns والـ Exons اللي
+
+516
+00:50:19,880 --> 00:50:24,500
+موجودة لهذا الشيء، الأصل أنا عندي A هنا البداية،
+
+517
+00:50:25,670 --> 00:50:31,370
+وببدأ الـ Intron 1، 2، 3، لحد 21، 22، وبعدين في
+
+518
+00:50:31,370 --> 00:50:36,010
+عندي Point ثانية عادة بتعمل مشكلة، وبعدين الـ 23،
+
+519
+00:50:36,010 --> 00:50:40,710
+هيك الأصل ينقرأ، هيك الأصل يكون طبيعي، فنتيجة
+
+520
+00:50:40,710 --> 00:50:47,510
+الـ Loop هذا اللي بحدث، فبيصير عندي أنه بدل ما هو
+
+521
+00:50:47,510 --> 00:50:52,790
+يبدأ بواحد، بيبدأ 22، 21، بقراه هيك، وبعدين 23 آخر
+
+522
+00:50:52,790 --> 00:50:59,920
+شيء، فالأمر بالنسبة لمن يكون ترتيب الـ "بروتين" الـ
+
+523
+00:50:59,920 --> 00:51:06,040
+"جين" بهذا الشكل، إنه خربان، ما بيفيدني، مش هيعطيني
+
+524
+00:51:06,040 --> 00:51:12,300
+الـ "بروتين" اللازم، وبالتالي بيعمل نقصان الـ
+
+525
+00:51:12,300 --> 00:51:18,020
+clotting factor، وبالتالي عملية النزف والمشاكل اللي
+
+526
+00:51:18,020 --> 00:51:22,800
+بيصيب عند الإنسان، هذا مثال على حالة ومرض وشغل معين،
+
+527
+00:51:22,800 --> 00:51:28,990
+بتكون إنه Okay، يعني بالأخير الكتل كلها موجودة، حجم
+
+528
+00:51:28,990 --> 00:51:40,270
+الـ DNA نفسه، بس ترتيبه مختلف وغلط، نفترض
+
+529
+00:51:40,270 --> 00:51:45,230
+إن أنا جبت أي واحد منا ودرست الـ Whole Genome
+
+530
+00:51:45,230 --> 00:51:51,390
+Sequencing، يعني الـ Whole Genome Sequencing، بذكر
+
+531
+00:51:51,390 --> 00:51:55,890
+مرة ثانية، لما عملناها من خلال الـ Human Genome
+
+532
+00:51:55,890 --> 00:52:03,610
+Project، بدوا بأواخر القرن اللي فات، أو من 2001 إلى
+
+533
+00:52:03,610 --> 00:52:08,370
+2003 لما خلّصوه، اشترك فيه حوالي، يعني يقال حوالي
+
+534
+00:52:08,370 --> 00:52:14,150
+700، 800 مختبر في العالم، ودفعوا مصاري كتير وطوّلوا
+
+535
+00:52:14,150 --> 00:52:20,230
+كتير، وبيقرأوها كانوا بيقرأوها بشكل بطيء، الآن
+
+536
+00:52:20,690 --> 00:52:26,330
+التقنية، بقول زي تقنية الكمبيوترات، بتلاقي إنه
+
+537
+00:52:26,330 --> 00:52:33,790
+الأجهزة صارت أسرع بكثير وبقدرات عالية جدًا، فالآن
+
+538
+00:52:33,790 --> 00:52:37,930
+إذا حد بده يعمل Whole Genome Sequencing، راح ناخد
+
+539
+00:52:37,930 --> 00:52:42,570
+عينه مرة ثانية، بقدر أبعث عينة الدم على المختبر اللي
+
+540
+00:52:42,570 --> 00:52:47,510
+بيعملها، يعني في الأردن تقريبًا نتكلم تقريبًا 600،
+
+541
+00:52:47,510 --> 00:52:52,520
+700 دينار، المختبرات العالمية بتعملها ومش أي مختبر،
+
+542
+00:52:52,520 --> 00:52:57,160
+يعني عادة يا هولندا يا كوريا، هذولا بيعتبروا عندنا
+
+543
+00:52:57,160 --> 00:53:03,220
+شاطرين وبيحاولوا يبعثوا الدم له، فالـ 9 مليارات الـ
+
+544
+00:53:03,220 --> 00:53:07,940
+Nucleotide اللي بيجيبوهن، المعلومات هذه بدها تكون
+
+545
+00:53:07,940 --> 00:53:14,160
+على External Hard Disk، يعني Two Terabytes، فاهمين
+
+546
+00:53:14,160 --> 00:53:20,090
+عليّ؟ بيدّيك كمية تعتبر هائلة من المعلومات، في الغالب
+
+547
+00:53:20,090 --> 00:53:25,890
+ما لهاش قيمة، راح نتكلم عنها لما نقعد، أنا أفرض Any
+
+548
+00:53:25,890 --> 00:53:29,390
+individual genome will contain the following، هذه
+
+549
+00:53:29,390 --> 00:53:37,110
+يعني أنا روحت مسكت بني آدم وأخذت دمه وقريت الـ 9
+
+550
+00:53:37,110 --> 00:53:44,250
+مليارات حرف في الـ DNA تبعه، وعندي إمكانية أقارن مع
+
+551
+00:53:45,000 --> 00:53:49,680
+الـ Reference Sequence،
+
+552
+00:53:49,680 --> 00:53:58,160
+اللي أنا أخذته Baseline، وبأجي بعمل المقارنة، بقدر
+
+553
+00:53:58,160 --> 00:54:05,300
+إنه من هالـ 9 مليارات، فيه حوالي من 5 إلى 10 مليون
+
+554
+00:54:05,300 --> 00:54:11,680
+SNP، يعني هتلاقي ما يقل، يعني لو جيت أخذت أنا
+
+555
+00:54:11,680 --> 00:54:16,820
+بالنسبة لأي قطعة ثانية أو لأي شخص اللي هو في الـ
+
+556
+00:54:16,820 --> 00:54:21,480
+Reference اللي بعتبره Reference، مش أقل من خمس
+
+557
+00:54:21,480 --> 00:54:26,360
+لعشر، لأ ملايين، Single Nucleotide Polymorphism،
+
+558
+00:54:26,360 --> 00:54:34,480
+بلاقيهم، منهم خمس وعشرين ألف لخمسين ألف، اللي هو
+
+559
+00:54:34,480 --> 00:54:39,040
+الـ Rare Variants، الـ Mutations الخاصة، والـ Seen or
+
+560
+00:54:39,040 --> 00:54:42,560
+Not Seen، في خمس بالمئة، وقليل من 5% من
+
+561
+00:54:42,560 --> 00:54:49,280
+الـ Individuals Tested، يعني حتى، يعني هنا السؤال لما
+
+562
+00:54:49,280 --> 00:54:53,900
+أشوف أنا اختلاف زي هيك، دائمًا هل هذا معناه أن هذا
+
+563
+00:54:53,900 --> 00:55:00,820
+مرض؟ هل هو حالة؟ هي عبارة عن كيف ترتيب الـ DNA
+
+564
+00:55:00,820 --> 00:55:08,330
+موجود في هذا الإنسان، ماشي، فاللي بدأ نحكي إنه مش
+
+565
+00:55:08,330 --> 00:55:13,550
+يعني في أي واحد منا راح يكون حوالي بالملايين، من
+
+566
+00:55:13,550 --> 00:55:19,890
+خمس إلى عشر ملايين SNP، اختلاف عن المصدر، الأشياء
+
+567
+00:55:19,890 --> 00:55:29,070
+هذه كثيرة، إذا شائعة، وكلمة شائعة، ماشي، هي علميًا لما
+
+568
+00:55:29,070 --> 00:55:34,530
+نقول Polymorphism، الـ Polymorphism لازم تكون موجودة
+
+569
+00:55:34,530 --> 00:55:39,350
+في أكثر من 1% من الناس، عندما تكون موجودة في 1% من
+
+570
+00:55:39,350 --> 00:55:46,730
+الناس، بنقول عنها Polymorphism، ماشي، إذا أقل من
+
+571
+00:55:46,730 --> 00:55:53,740
+وجودها بين البشر، أقل من 1%، بنعتبرها Variation أو
+
+572
+00:55:53,740 --> 00:55:59,380
+Mutations، وبنعتبرها ما وصلت Polymorphism، وإن كان
+
+573
+00:55:59,380 --> 00:56:02,820
+Polymorphism أو غيره، ممكن إثنانهم يسببوا مرض، يعني
+
+574
+00:56:02,820 --> 00:56:08,500
+فبتوقع الواحد من 25 ألف لـ 50 ألف Rare Variant في
+
+575
+00:56:08,500 --> 00:56:15,440
+أي إنسان، تقريبًا 75، محل New Base Pair Mutation Not
+
+576
+00:56:15,440 --> 00:56:21,820
+Detected in Parental Genomes، يعني أي واحد مننا
+
+577
+00:56:21,820 --> 00:56:26,560
+متوقع، ما هو الخلايا بدأت تنقسم، بدأت تعيد بناء الـ
+
+578
+00:56:26,560 --> 00:56:33,400
+DNA، البناء الـ DNA مش 100%، يعني لا يمكن يخطئ فيه،
+
+579
+00:56:33,400 --> 00:56:41,200
+نسبة خطأ كبيرة، الإشعاع، والكيمياويات، والأمراض،
+
+580
+00:56:41,200 --> 00:56:46,940
+مرات، و ليش بيصير cancers وكذا، لأنه بيتم إدخال طفرة
+
+581
+00:56:46,940 --> 00:56:51,620
+معينة، المادة اللي بالذات، إذا الواحد بتكلم عنه الـ
+
+582
+00:56:51,620 --> 00:56:58,220
+Autosome، الـ Dominant، طيب إنسان ما عندهوش بين أبواه
+
+583
+00:56:58,220 --> 00:57:05,560
+المرض السائد، بدأت الطفرة عنده هو، فبالتالي في 75
+
+584
+00:57:05,560 --> 00:57:09,870
+expected new base pair mutations، ما كانت ظاهرة عند
+
+585
+00:57:09,870 --> 00:57:18,190
+أب وأم الشخص، أي واحد مننا فيه "CNVs"، يعني قطعة
+
+586
+00:57:18,190 --> 00:57:23,210
+أكبر من الـ "DNA"، بتِم يعني إضافتها أو تكرارها،
+
+587
+00:57:23,210 --> 00:57:29,770
+حوالي من 200 ألف لـ 500 ألف Indels، اللي هو
+
+588
+00:57:29,770 --> 00:57:34,610
+"إنسيرشن" أو "ديليشن"، من واحد لخمسين base pair،
+
+589
+00:57:34,610 --> 00:57:40,360
+varies by population، يعني إذا اتكلمنا من خمس ملايين
+
+590
+00:57:40,360 --> 00:57:47,880
+لعشر ملايين SNP، منهم حوالي يعني أقل منهم بكثير،
+
+591
+00:57:47,880 --> 00:57:53,460
+بتلاقي اللي هو الـ Insertions والـ Deletions، بتخيل و
+
+592
+00:57:53,460 --> 00:57:58,620
+بقدر فيه ألف Deletions بيكونوا
+
+593
+00:57:58,620 --> 00:58:07,230
+أصغر شوية، فيه 150 In-Frame، In-Deletions، لـ 250
+
+594
+00:58:07,230 --> 00:58:11,330
+Shifts، فيه
+
+595
+00:58:11,330 --> 00:58:18,350
+100 ألف لـ 12 ألف Synonymous SNPs، من حوالي برضه 10
+
+596
+00:58:18,350 --> 00:58:26,010
+ألف Non-Synonymous SNPs، يعني الفكرة إنه أنا لما
+
+597
+00:58:26,010 --> 00:58:32,460
+أنا قاعد أخد أي واحد منها وأسوي له Whole Genome
+
+598
+00:58:32,460 --> 00:58:38,340
+Sequencing، في الغالب، راح ألاحظ عدد كبير من
+
+599
+00:58:38,340 --> 00:58:45,320
+الاختلافات عن الـ Reference Range، المصدر الرئيسي
+
+600
+00:58:45,320 --> 00:58:49,800
+أو المرجع الأساسي تبعنا، ويكون فيه اختلافات كثيرة،
+
+601
+00:58:49,800 --> 00:58:55,440
+حتى ممكن عن والدي ووالدتي، وكل واحد مننا ربنا خالقه
+
+602
+00:58:55,440 --> 00:59:04,900
+بطريقة مميزة، سبحان الله، في أسئلة؟ يعني دكتورة
+
+603
+00:59:04,900 --> 00:59:13,500
+أسماء تسأل، الأرقام الموجودة في الـ "سلايد" دي كتير
+
+604
+00:59:13,500 --> 00:59:17,060
+يعني مش قادرة تستوعب إيش المطلوب، فهو إيش المختصر أو
+
+605
+00:59:17,060 --> 00:59:21,620
+المطلوب من الـ "سلايد" اللي زي هيك؟ المختصر
+
+606
+00:59:21,620 --> 00:59:29,100
+المطلوب إنه إذا لو سألتها "كم نيكليوتايد موجود؟"
+
+607
+00:59:29,100 --> 00:59:33,790
+لما أنا أقراهم، المفروض تقول لي تقريبًا تسعة مليارات أو
+
+608
+00:59:33,790 --> 00:59:37,630
+ثلاثة مليارات، يعني ثلاثة في عشرة أقصد تسعة
+
+609
+00:59:37,630 --> 00:59:44,670
+نيكليوتيد، هيك الـ Whole Genome تبع الإنسان، فلما
+
+610
+00:59:44,670 --> 00:59:52,690
+أدرس أي بني آدم، تقريبًا فيه من خمس لعشر ملايين
+
+611
+00:59:52,690 --> 00:59:59,520
+SNP، يعني هي أولها، يعني هل طبعًا عشر ملايين، لو
+
+612
+00:59:59,520 --> 01:00:02,680
+افترضنا عشر ملايين، يعني كده إيش؟ يعني عشر قوة
+
+613
+01:00:02,680 --> 01:00:07,580
+السبعة، صح؟ هذيك الثلاثة في عشر قوة التسعة، ففي
+
+614
+0
+
+667
+01:05:43,200 --> 01:05:48,140
+خلّيني بس أشيل هذه،
+
+668
+01:05:48,140 --> 01:05:54,080
+مش راضي، بس ما في، طيب،
+
+669
+01:06:01,460 --> 01:06:04,920
+أنا بظن أنَّ الـ «سلايد» هذا من أهم الأشياء الواحد
+
+670
+01:06:04,920 --> 01:06:12,760
+يكون فاهمه لما أنا بدي أو بفكر أنَّ فيه مشكلة على
+
+671
+01:06:12,760 --> 01:06:20,700
+مستوى الـ «كروموزوم»، على مستوى الـ… على مستوى
+
+672
+01:06:20,700 --> 01:06:28,100
+العدد الكبير من قطعة الـDNA بحاجة أن أعمل الفحص
+
+673
+01:06:28,100 --> 01:06:32,660
+اللي بنسميه «Standard Karyotype»، الـ Karyotyping
+
+674
+01:06:32,660 --> 01:06:42,800
+اللي هو قلت لكم بتجيب خلايا سواء دم أو غيره بتعطي
+
+675
+01:06:42,800 --> 01:06:48,340
+مادة زي الـ Colchicine في الدواء اللي بيمنع تكوين
+
+676
+01:06:48,340 --> 01:06:54,720
+الـ Spindle Fiber فتقدرش الكروموزومات تنفصل لقطبين
+
+677
+01:06:54,720 --> 01:06:59,960
+في انقسام الخلية، وبالتالي بتظل الكروموزومات بالنص
+
+678
+01:07:00,620 --> 01:07:05,980
+بتروح، بتوقف على طاولة عالية، يعني كنا تقريبًا
+
+679
+01:07:05,980 --> 01:07:12,120
+ارتفاع متر ونص، ثلاثة أو أقل من ثلاثة، بالخلايا اللي
+
+680
+01:07:12,120 --> 01:07:18,020
+بتكون، يعني أتأمَّل إذا كان فيه ثوان، حتى لو تشوفوا
+
+681
+01:07:18,020 --> 01:07:24,580
+فيديو كيف بنعمل الـKaryotype هذا، بتسقطها على
+
+682
+01:07:24,580 --> 01:07:32,100
+الـSlides، وبعدين بتصير عملية الصبغ للـ Chromosomes
+
+683
+01:07:32,100 --> 01:07:40,080
+وبيبين عندها الـ DNA بالشكل المضغوط اللي هو على
+
+684
+01:07:40,080 --> 01:07:46,220
+شكل الـ Chromosomes، الـ 23 زوج اللي هو الـ 22
+
+685
+01:07:46,220 --> 01:07:52,910
+أُتَظَامِن والـ X والـ Y، لما نعمل بهذه الطريقة بنكون
+
+686
+01:07:52,910 --> 01:07:56,310
+اللي هو «Standard Karyotyping»، وبيكون بيسموه
+
+687
+01:07:56,310 --> 01:08:00,790
+«Routine Banding»، يعني هذه طريقة حتى نعرف، وراح
+
+688
+01:08:00,790 --> 01:08:04,470
+نشوف أمثلة كده، بيكون شكل الأشياء اللي بيطلع حقيقة
+
+689
+01:08:04,470 --> 01:08:10,550
+معنا، وبيكون هاي لما أنا أشك أنَّه بيعندي مشكلة فيها
+
+690
+01:08:10,550 --> 01:08:13,290
+عدد، يعني زي «Down Syndrome»، «Turner»، «Cri du Chat»
+
+691
+01:08:13,290 --> 01:08:16,890
+أمراض زي هيك، بتلاقي أني بعمل هذه الطريقة
+
+692
+01:08:17,420 --> 01:08:22,800
+وهنا بيكون الـ… يعني ما في إمكانية أنَّه يتكلم عن
+
+693
+01:08:22,800 --> 01:08:27,260
+إشي متخصص «سنب» ومش «سنب» وكده، لأ إحنا ما بنتكلم
+
+694
+01:08:27,260 --> 01:08:32,940
+عن هذا الـBanding، العادية بيعطينا عدد معين من الـ…
+
+695
+01:08:32,940 --> 01:08:36,960
+المطاقات
+
+696
+01:08:36,960 --> 01:08:42,970
+على الـChromosome، ممكن أنَّ أنا أحسن الموضوع شوية
+
+697
+01:08:42,970 --> 01:08:48,370
+لأعمل High-Resolution Banding، يعني إذا أنا شكيت
+
+698
+01:08:48,370 --> 01:08:54,790
+طبعًا إحنا هنا هاي ثلاثة مليارات Base pair، اللي يعني
+
+699
+01:08:54,790 --> 01:08:59,450
+إحنا لما نحكي عن الكروموزومات والـDNA بشكل كلي، بدنا
+
+700
+01:08:59,450 --> 01:09:04,710
+نتكلم على عدد كبير من الـNucleotides، عشرة أو
+
+701
+01:09:04,710 --> 01:09:09,920
+ستة تسعة، ماشي؟ لما بدي أدّي أنا مثلًا في بعض الأمراض
+
+702
+01:09:09,920 --> 01:09:14,460
+والحالات بتكون مربوطة باختلال في قطعة أصغر شوية
+
+703
+01:09:14,460 --> 01:09:20,900
+يعني هو أنا ثلاثة ملايين لـمليون Base Pair، سواء
+
+704
+01:09:20,900 --> 01:09:30,700
+Deletion، Copy Number Increase،كذا، فهنا إذا بستخدم يعني
+
+705
+01:09:30,700 --> 01:09:38,740
+High 400 لـ 550 Band Stage أو 850 Band Stage، تسمّوه
+
+706
+01:09:38,740 --> 01:09:42,980
+هنا High-Resolution Banding، لما أنا أقرب على أنَّه
+
+707
+01:09:42,980 --> 01:09:49,260
+أنا بحاجة أنَّ أدرس إذا في بعض الأمراض نتيجة اختلال
+
+708
+01:09:49,260 --> 01:09:56,770
+بقطعة أكبر شوية من الـ… من الـDNA، بدي أعمل High
+
+709
+01:09:56,770 --> 01:10:01,310
+-Resolution Banding، راح نشوف بعض الصور بعدين، في
+
+710
+01:10:01,310 --> 01:10:08,430
+أشياء بتكون لأ، يعني بقدر أدرس على قطع أصغر شوية
+
+711
+01:10:08,430 --> 01:10:11,970
+Comparative Genome Hybridization أو الـFISH
+
+712
+01:10:11,970 --> 01:10:19,290
+Analysis أو الحمد لله Chromosomal Microarray
+
+713
+01:10:19,290 --> 01:10:28,570
+الـFISH راح نشوف صورتها كيف، الـ Fluorescent In Situ
+
+714
+01:10:28,570 --> 01:10:34,450
+Hybridization، هيك الاختصار تبعها، وهنا يعني
+
+715
+01:10:34,450 --> 01:10:40,310
+قريبًا صرنا نأخذ زي الـ Microarray، أنا بجيب قطعة
+
+716
+01:10:40,310 --> 01:10:47,070
+مُكافئة لإيش أنا بدي إياها، وبالتالي بصير أدور عليها في
+
+717
+01:10:47,070 --> 01:10:52,730
+كل الـGenome، وبشوف، بعدين سواء بعمل Electrophoresis
+
+718
+01:10:52,730 --> 01:10:58,110
+بشوف كيف توزعت، شو أحجام القطع اللي موجودة فيها
+
+719
+01:10:58,110 --> 01:11:02,230
+ويكون هذا مؤشر على مرض معين، خلال معين، ظاهرة
+
+720
+01:11:02,230 --> 01:11:09,670
+معينة، وإذا بدي أروح على تفصيل أدق، بدي أبدأ أعمل
+
+721
+01:11:09,670 --> 01:11:13,430
+Whole Genome Sequencing، هذا اللي بكلف، يعني
+
+722
+01:11:13,430 --> 01:11:21,390
+الـKaryotype، يعني بقدر، يمكن 20، 30 دينار بيكفي
+
+723
+01:11:21,390 --> 01:11:27,070
+بيعملوه، يعني عبارة عن جهد بشري وشوية مواد بسيطة
+
+724
+01:11:27,070 --> 01:11:35,030
+وصبغات وخلاص، هنا النتيجة راح تكون يعني 9 مليارات
+
+725
+01:11:35,030 --> 01:11:42,730
+حرف، ويعني العقدة مش المشكلة اللي حتعملها، بس
+
+726
+01:11:42,730 --> 01:11:49,250
+الأجهزة بتعملها، بس حتدلّني على وين أدور، وماذا
+
+727
+01:11:49,250 --> 01:11:56,370
+أتَدَوَّر، وما الخلل الموجود، يعني هذه النقطة
+
+728
+01:11:56,370 --> 01:12:01,150
+فهنا increasing resolution، يعني درجة التعقيد أكثر
+
+729
+01:12:01,150 --> 01:12:06,070
+من النظرة في الدراسة
+
+730
+01:12:06,070 --> 01:12:08,810
+وهكذا يكون ترتيب الأمور
+
+731
+01:12:12,270 --> 01:12:20,290
+بالنسبة لما نعمل كاريوتايب، أنا بس بدي أفرجيكم هنا
+
+732
+01:12:20,290 --> 01:12:26,170
+هذه أقرب صورة، يمكن هذه الصورة، هيك، ماشي؟ هيك بيكون
+
+733
+01:12:26,170 --> 01:12:29,550
+شكل الكاريوتايب، يعني هذه الـBands، هيك عادة
+
+734
+01:12:29,550 --> 01:12:37,310
+بنلاقيها، فلما أنا آجي أدرس الـ… الـ… الـIdiogram
+
+735
+01:12:37,310 --> 01:12:43,330
+ماشي، الـ «G-banding pattern for human chromosomes
+
+736
+01:12:43,330 --> 01:12:46,950
+at metaphase with approximately 400 bands per
+
+737
+01:12:46,950 --> 01:12:53,310
+haploid set»، يعني بيكون هيك ترتيب الأمور، مثلًا هذا
+
+738
+01:12:53,310 --> 01:12:58,010
+الـChromosome الأول، بتبدأ من واحد من هون، وبعدين
+
+739
+01:12:58,010 --> 01:13:03,030
+إيه، بتصير نعطيه أرقام، وبتصير أي يعني أشياء تقريبًا
+
+740
+01:13:03,030 --> 01:13:12,290
+مُصطلَح عليها، وبتكون هيك شكلها، لما قاعد أدرس أي كاريو
+
+741
+01:13:12,290 --> 01:13:16,550
+تايب، بيعطيني هذه الأشياء، ممكن إذا أنا عارف مثلًا
+
+742
+01:13:16,550 --> 01:13:23,510
+«دي جورج سندروم» تبع المناعة،
+
+743
+01:13:23,510 --> 01:13:30,870
+ماشي؟ فيه على كروموزوم 21، الـP تحت فيه بيصير أنَّه
+
+744
+01:13:30,870 --> 01:13:35,250
+«تُخْلُص»، بيصير أنَّه «تغيير»، بيصير أنْ فيه خلل معين
+
+745
+01:13:35,250 --> 01:13:42,050
+بتعطيني مشكلة، فإذا أنا يعني مش عندي شك سلفًا
+
+746
+01:13:42,050 --> 01:13:48,050
+بموقع معين، بمرض معين، بحالة معينة، بطلب الـKaryotype
+
+747
+01:13:48,050 --> 01:13:52,750
+وبخليه يدور لي على هل الـBand زي ما أنا شايفه هنا
+
+748
+01:13:52,750 --> 01:13:59,830
+مُظْبُطَة، هي الطبيعية المتوقعة، أو فيها اختلاف، هنا الـ
+
+749
+01:13:59,830 --> 01:14:07,070
+«Chromosome 5»، وهذه نستخدم صبغة ثانية، فبتعطينا بَلْ
+
+750
+01:14:07,070 --> 01:14:13,850
+يعني نطاقات أكثر، فهذه ممكن أستخدمها، علشان إذا برضه
+
+751
+01:14:13,850 --> 01:14:20,170
+في حالة ثانية بتلاقيني بحتاج أن أعملها بتفصيل أكثر
+
+752
+01:14:20,170 --> 01:14:28,080
+في موقع معين، يعني الاختلافات، وبعد شوية، أظن واحدة
+
+753
+01:14:28,080 --> 01:14:37,020
+اللي هي 850 Band، يعني طريقة بتكون بتعطيني أداء، بس
+
+754
+01:14:37,020 --> 01:14:40,980
+هاي كلها أشياء يعني، حتى أُحَدِّد شو المطلوب، بدي يكون
+
+755
+01:14:40,980 --> 01:14:44,840
+حسب المرض، حسب الحالة، شو المعروف من قبل، وين
+
+756
+01:14:44,840 --> 01:14:51,530
+الخلل في مثل هذا المرض، وبالتالي بصير أدور عليه فيه
+
+757
+01:14:51,530 --> 01:14:56,050
+تقنية اسمها الـ Fluorescence in Situ Hybridization
+
+758
+01:14:56,050 --> 01:15:06,610
+يعني أنا عندي الآن بتسير مثلًا لأمراض، نفترض مرض
+
+759
+01:15:06,610 --> 01:15:11,450
+خطير، مرض يعني
+
+760
+01:15:11,450 --> 01:15:17,250
+مثلًا مرعب، مثلًا مرات بدا الواحد كمرض، وراثة اللي
+
+761
+01:15:17,250 --> 01:15:23,100
+هو مثلًا نفترض إشي مرعب، راح تاخدوا إشي اسمه
+
+762
+01:15:23,100 --> 01:15:27,340
+«Huntington’s disease»، عبارة عن مرض بيسبب شلل
+
+763
+01:15:27,340 --> 01:15:34,180
+رعاشي، وبيسبب وفاة، وبيسبب يعني وفاة سريعة، بشلل
+
+764
+01:15:34,180 --> 01:15:40,940
+للأسف هو سائد، يعني autosomal dominant، وبيبدأ في
+
+765
+01:15:40,940 --> 01:15:47,640
+الناس على عمر الأربعين، يعني عادة الأمراض الشديدة
+
+766
+01:15:47,640 --> 01:15:53,290
+بتلاقيها بتبدأ بشكل مبكر، والطفل المصاب ما بيخلف، ما
+
+767
+01:15:53,290 --> 01:15:59,130
+بيِتْزَوَّج، إنما هذا حالة يعني خطيرة، إذا الواحد بيشوف
+
+768
+01:15:59,130 --> 01:16:02,650
+حدًّا من أهله عنده إياها، وبتبدأ على عمر الأربعين
+
+769
+01:16:02,650 --> 01:16:09,890
+بيكون الواحد صار متجوز ومخلف وكده، فاللي راح يصير
+
+770
+01:16:09,890 --> 01:16:15,130
+إذا اكتشفت هذه الحالة، أنَّ الأقارب، الأولاد، البنات،
+
+771
+01:16:15,130 --> 01:16:18,050
+يصيروا كلهم مرعوبين، طب أنا حامل هذا الجين ولا مش
+
+772
+01:16:18,050 --> 01:16:24,780
+حامل هذا الجين؟ عندي يا ولا ما عنديش يا؟ فإذا عندي
+
+773
+01:16:24,780 --> 01:16:33,560
+نتيجة حالات من قبل، نتيجة دراسات من قبل، الـProbe
+
+774
+01:16:33,560 --> 01:16:42,560
+يعني قطعة صغيرة، زي مفتاح، زي لما نحن مثلًا إذا نشبّه
+
+775
+01:16:42,560 --> 01:16:49,880
+الموضوع المرة الثالثة، لما تعمل Google Search، قفة
+
+776
+01:16:49,880 --> 01:16:56,020
+نَبْكِي من ذكرى حبيب، خلاص، بحط هاي القطعة، وبيكون هاي
+
+777
+01:16:56,020 --> 01:17:00,520
+نفترض الـ Probe بهذا الشكل، هي مؤشر على الإنسان
+
+778
+01:17:00,520 --> 01:17:06,360
+الطبيعي، عشان القصيد الأصلية الطبيعية، ولكن نفترض
+
+779
+01:17:06,360 --> 01:17:12,540
+للناس اللي عندهم المرض، أن يكون الـ Probe بشكل قفة
+
+780
+01:17:12,540 --> 01:17:18,480
+من ذكرى حبيب، ما جبش القطعة، نبكي من ذكراه، يا عزيزي
+
+781
+01:17:18,480 --> 01:17:22,900
+لأنَّه انْشَطَبَت هذه القطعة أو النقطة الصغيرة، فصار أنا
+
+782
+01:17:22,900 --> 01:17:31,280
+عندي في مفتاح آخر، بقدر أستفيد منه، أني أدرس على
+
+783
+01:17:31,280 --> 01:17:38,160
+الجين المصاب، فباجي أنا تقنية الـFluorescence in
+
+784
+01:17:38,160 --> 01:17:49,030
+Situ Hybridization، هنا الحاطّين اللي هو الـ 4q12
+
+785
+01:17:49,030 --> 01:17:54,950
+Red Fluorescence، هذا قطعة معينة مثلًا في الناس
+
+786
+01:17:54,950 --> 01:18:02,710
+الطبيعيين بتكون بهذا الشكل، والـ 4q31.1 بتكون
+
+787
+01:18:02,710 --> 01:18:09,750
+بتعطيني لون Green، فباجي أنا بجيب خلايا العائلة
+
+788
+01:18:09,750 --> 01:18:15,830
+المطلوبة دراستها، ومثلًا أنا استخدمت هدول الاثنين
+
+789
+01:18:15,830 --> 01:18:21,830
+وبعدين هدول الـ Fluorescence dye اللي هي الأصباغ
+
+790
+01:18:21,830 --> 01:18:26,270
+المُشِعَّة، أو الأصباغ اللي
+
+791
+01:18:26,270 --> 01:18:32,710
+لها Fluorescence، ماشي؟ بتصير تبين عندي بشكل أحمر
+
+792
+01:18:32,710 --> 01:18:39,710
+أو أخضر، حسب اللي أنا موجود، فطبعًا
+
+793
+01:18:39,710 --> 01:18:49,390
+هنا الـ… يعني تفاصيل الواحد، إذا بدّه يفهم مثل هيك
+
+794
+01:18:49,390 --> 01:18:54,430
+صورة، بدّه يقرأ بالتفصيل الدقيق الممل، «شو الحالة؟»
+
+795
+01:18:54,430 --> 01:18:58,380
+«إيش كان الـProbe؟» «ليش أخذوها؟» من وين طَلَّعُوها؟ شو
+
+796
+01:18:58,380 --> 01:19:03,000
+الـ sensitivity والـ specificity؟ يعني كم نثبت أنَّه
+
+797
+01:19:03,000 --> 01:19:07,700
+هذه الطفرة بهذا الشكل، هي في المرض هذا، حقيقة مؤشر
+
+798
+01:19:07,700 --> 01:19:15,160
+عليها ولا مش مؤشر عليها؟ يعني دائمًا الفحوصات عبارة
+
+799
+01:19:15,160 --> 01:19:21,060
+عن شيء أحيانًا له تأثير شديد كتير كتير كتير، يعني
+
+800
+01:19:21,060 --> 01:19:26,180
+إحنا سواء الآن كل كلامنا على فحص الـCOVID مثلًا، ما
+
+801
+01:19:26,180 --> 01:19:32,480
+فيش فحص في العالم COVID، ولا حتى HIV، ولا كذا 100%
+
+802
+01:19:32,480 --> 01:19:38,460
+في كل شيء، يعني أنَّه لإنَّ الفحص أحسن شيء، لازم 100% من
+
+803
+01:19:38,460 --> 01:19:44,200
+المصابين، الفحص يقول لي أن هذا مصاب، وبنفضّل يكون 100%
+
+804
+01:19:44,200 --> 01:19:47,560
+باللي غير مصابين، يطلع لنا الفحص أن هذا غير مصاب
+
+805
+01:19:47,560 --> 01:19:51,380
+فهذه الظاهرة اللي بنسميها Sensitivity وSpecificity
+
+806
+01:19:51,380 --> 01:19:58,260
+هذه أمور ما بتكون 100%، الـ 99% بيكون مقبول، بس ممكن
+
+807
+01:19:58,260 --> 01:20:03,240
+تكون تعطي مشكلة كبيرة، الـ 1% اللي ما عنده المرض
+
+808
+01:20:03,240 --> 01:20:08,220
+بتقول له عندك المرض، بيروح بينتحر، يعني مرات إذا كانت
+
+809
+01:20:08,220 --> 01:20:14,440
+تَصِير لما يسمع أنَّه عنده حالة خطيرة، حالة مرض كده
+
+810
+01:20:14,440 --> 01:20:18,260
+فالصورة
+
+811
+01:20:18,260 --> 01:20:23,480
+هذه بتقول لنا أنَّه من الأدوات الموجودة عندنا لفحص
+
+812
+01:20:24,310 --> 01:20:32,110
+الوراثة، وأحيانًا للتعامل مع التشخيص ضمن عائلة معينة
+
+813
+01:20:32,110 --> 01:20:37,530
+لمرض معين، لحالة معينة، ويبقى الواحد يرجع لِمَراجع من
+
+814
+01:20:37,530 --> 01:20:43,890
+قبل، ويكون فاهم شو الفحص اللي بعمله، باجي بدور علشان
+
+815
+01:20:43,890 --> 01:20:52,430
+أقدر أُشَخِّص هل الطفرة اللي يعني المُدَلِّلة على مرض معين
+
+816
+01:20:52,430 --> 01:20:59,460
+موجودة أو غير موجودة، فيها سلاح، فهذا اللي هو الـ
+
+817
+01:20:59,460 --> 01:21:03,800
+«تكنيك» اللي اسمه «FISH»، «Fluorescence in Situ
+
+818
+01:21:03,800 --> 01:21:13,220
+Hybridization»، بفيدني أني أنا على مستوى من متوسط
+
+819
+01:21:13,220 --> 01:21:20,400
+الحساسية، متوسط الدقة، من ما بين الـ«Karyotype»
+
+820
+01:21:20,400 --> 01:21:23,850
+والـ«Whole Genome Sequencing»، فهي يعني مبدأ، أنا
+
+821
+01:21:23,850 --> 01:21:27,310
+بهمني أن تكونوا فاهمينه، قضية أنَّه إذا كنت
+
+822
+01:21:27,310 --> 01:21:32,950
+أستخدم Micro-satellite أو FISH أو Probe، أنا بدور
+
+823
+01:21:32,950 --> 01:21:39,030
+بطريقة بين أنَّه أدرس الـChromosome كله، والجينوم كله
+
+824
+01:21:39,030 --> 01:21:45,190
+أو Whole-Genome Sequencing، بكون درست بشكل دقيق
+
+825
+01:21:45,190 --> 01:21:53,710
+كتير، إذا ما اخترت الأداء المناسبة، يعني هنا حكينا ما
+
+826
+01:21:53,710 --> 01:21:58,730
+بعرفش كده، كُلفة الـ… بس لما يكون فيه fluorescence
+
+827
+01:21:58,730 --> 01:22:03,890
+لهذا الشكل، الجهاز، الميكروسكوب، غالي، وكُلفته أكبر
+
+828
+01:22:03,890 --> 01:22:09,750
+من أن يكون عندك المواد، بتكون أثمن وأغلى أنك تجيبها
+
+829
+01:22:09,750 --> 01:22:13,150
+يعني تبع الـKaryotype، بقدر عشرين، ثلاثين، أربعين
+
+830
+01:22:13,150 --> 01:22:20,480
+دينار، يعني maximum، هدول نتكلم على بالمئات، بس الـ
+
+831
+01:22:20,480 --> 01:22:24,220
+Whole Genome Sequencing، أبقى أنا، لأن بقدر تقريبًا
+
+832
+01:22:24,220 --> 01:22:29,380
+300، 700 دينار أردني، يعني هيك بيقولون
+
+889
+01:28:37,570 --> 01:28:41,910
+اتكلمنا قبل شوية عنه، اللي هي مواضيع أمراض اللي
+
+890
+01:28:41,910 --> 01:28:46,870
+بنعتبرها طفرات على مستوى الـNucleotide، يعني على
+
+891
+01:28:46,870 --> 01:28:50,850
+مستوى شيء دقيق كثير، لما هنا إحنا قطعة
+
+892
+01:28:50,850 --> 01:28:54,390
+الـChromosome الكبير هذه، عادة لازم تكون Balanced
+
+893
+01:28:54,390 --> 01:29:04,190
+حتى الإنسان يظل عايش، يعني لما نحكي المصطلحات
+
+894
+01:29:04,380 --> 01:29:10,160
+يعني إحنا فيه كمان بنبه، راح نتفرج بعدين على اللي
+
+895
+01:29:10,160 --> 01:29:15,600
+بيسموه الـ «family
+
+896
+01:29:15,600 --> 01:29:19,120
+pedigree»، يعني اللي هي شجرة العائلة، كيف نرسمها؟ كيف
+
+897
+01:29:19,120 --> 01:29:23,500
+نقراها؟ شو المعلومات اللي بدنا نحطها؟ كل ما الواحد
+
+898
+01:29:23,500 --> 01:29:31,080
+يشوف حالة، لازم كطبيب حتى يعني يوثق الحالة ويكون
+
+899
+01:29:31,080 --> 01:29:35,850
+مدعاة أكبر للنشر، ويكون الناس متفقين في المعلومة اللي
+
+900
+01:29:35,850 --> 01:29:39,750
+بذكرها، لازم على طول يرسم الـPedigree تبع العائلة.
+
+901
+01:29:39,750 --> 01:29:43,830
+وفي نفس الوقت، لما واحد يشتغل الشغل تبع
+
+902
+01:29:43,830 --> 01:29:48,550
+الـSequencing أو الـKaryotype أو الأشياء الثانية،
+
+903
+01:29:48,550 --> 01:29:52,610
+الـMicroarrays أو الـFISH أو غيره، بده يستخدم
+
+904
+01:29:52,610 --> 01:29:55,850
+المصطلحات المتفق عليها بالطريقة المتفق عليها.
+
+905
+01:29:55,850 --> 01:30:00,430
+فالـSynteny، «سينترومير»، «دل»، «دليشن»، طبعاً
+
+906
+01:30:00,430 --> 01:30:05,920
+الـExample لما نقول إحنا الـKaryotype 46XX هذا الـ
+
+907
+01:30:05,920 --> 01:30:10,140
+Normal Female Karyotype، الـ46XY Normal Male
+
+908
+01:30:10,140 --> 01:30:13,800
+Karyotype «سنترومير»، «سنترومير»، «سنترومير»،
+
+909
+01:30:13,800 --> 01:30:14,500
+«سنترومير»، «سنترومير»، «سنترومير»، «سنترومير»،
+
+910
+01:30:14,500 --> 01:30:15,720
+«سنترومير»، «سنترومير»، «سنترومير»، «سنترومير»،
+
+911
+01:30:15,720 --> 01:30:16,560
+«سنترومير»، «سنترومير»، «سنترومير»، «سنترومير»،
+
+912
+01:30:16,560 --> 01:30:18,620
+«سنترومير»، «سنترومير»، «سنترومير»، «سنترومير»،
+
+913
+01:30:18,620 --> 01:30:22,780
+«سنترومير»، «سنترومير»، «سنترومير»، «سنترومير»،
+
+914
+01:30:22,780 --> 01:30:30,120
+«سنترومير»، «سنترومير»
+
+915
+01:30:30,850 --> 01:30:34,530
+الـShort Arm of Chromosome، يعني هذه المصطلحات
+
+916
+01:30:34,530 --> 01:30:41,610
+اللي «Gain» أو «Loss» أو «Mosaicism»، الموزاييك يعني
+
+917
+01:30:41,610 --> 01:30:46,970
+إنه فيه أكثر من شكل في نفس الإنسان، ماشي؟ فهؤلاء و
+
+918
+01:30:46,970 --> 01:30:50,670
+الـTranslocation و الـRobertsonian
+
+919
+01:30:50,670 --> 01:30:53,170
+Translocation، Ring Chromosomes.
+
+920
+01:30:55,720 --> 01:31:03,100
+يعني هذه أمثلة على بعض المصطلحات أو الاختصارات
+
+921
+01:31:03,100 --> 01:31:09,300
+المستخدمة، حتى الواحد لما يقرا بعدين أو يشوف الـP
+
+922
+01:31:09,300 --> 01:31:14,440
+short arm of the chromosome، الـQ long arm of the
+
+923
+01:31:14,440 --> 01:31:18,460
+chromosome، الـPaternal origin، الـMaternal اللي من
+
+924
+01:31:18,460 --> 01:31:24,970
+الأم أو من الأب، إذا بيفرق من وين أجت القطعة، ويعني
+
+925
+01:31:24,970 --> 01:31:31,470
+هنا هم عاملين «Karyotype» على «FISH» على
+
+926
+01:31:31,470 --> 01:31:36,450
+«Microarray Study»، بتلاقي أحياناً في دراسة حالة
+
+927
+01:31:36,450 --> 01:31:41,230
+معينة بيحط لك رسمات فيها أشياء زي هيك، ماشي؟
+
+928
+01:31:44,890 --> 01:31:51,270
+حكينا في أحيانًا يصير عندي الـNon-disjunction، هنا
+
+929
+01:31:51,270 --> 01:31:57,090
+حاطين، أو عملية الـTranslocation أو Isochromosome
+
+930
+01:31:57,090 --> 01:32:01,290
+أو Robertsonian Translocation أو كذا، Duplication
+
+931
+01:32:01,290 --> 01:32:09,790
+يعني هدول كلهم اختلالات على مستوى الـDNA، ممكن
+
+932
+01:32:09,790 --> 01:32:15,730
+الانتباه الها من خلال الـKaryotype، ممكن عن طريق
+
+933
+01:32:15,730 --> 01:32:21,250
+الـFISH أو أشياء أقل، بس يعني هاي لإنك تحاول تعمل
+
+934
+01:32:21,250 --> 01:32:27,030
+Sequencing ما لها معنى، ماشي؟ بدك تشوف، فطبعاً
+
+935
+01:32:27,030 --> 01:32:33,730
+أهمية هذه النقاط إذا كانت Balanced، نفس الإنسان
+
+936
+01:32:33,730 --> 01:32:42,790
+بيكون يعني طبيعي، عنده التَّقَم الكامل من الجينات، تَقَم
+
+937
+01:32:42,790 --> 01:32:48,490
+كامل من المادة الوراثية، وبالتالي ما عندهوش
+
+938
+01:32:48,490 --> 01:32:54,170
+هو مشكلة، لأن اللي عنده Balance، أما لما يكون نتيجة
+
+939
+01:32:54,170 --> 01:33:00,850
+بعدين في محاولة يعني، قطعة كروموزوم معينة انتقلت من
+
+940
+01:33:00,850 --> 01:33:05,610
+مكان من محل لمحل، فاللي بيصير أنه اللي انتقلت منه
+
+941
+01:33:05,610 --> 01:33:10,140
+راح يصير أقصر ويصير ناقص، واللي فيها زيادة عنده
+
+942
+01:33:10,140 --> 01:33:14,840
+نسختين، أحيانًا نسختين مهمات، فلو عند الواحد نسختين
+
+943
+01:33:14,840 --> 01:33:19,560
+ولو إنه مع نفس المحل بس بيمشي الحال، فهسّا لما ييجي
+
+944
+01:33:19,560 --> 01:33:25,240
+هو يتزوج ويريد يخلف، بتلاقي إذا كانت النسخة هي اللي
+
+945
+01:33:25,240 --> 01:33:30,860
+فيها نقص، راح يصير إن هذا الجنين لن يعيش، إذا كانت
+
+946
+01:33:30,860 --> 01:33:38,110
+الجاميت في الشيء اللي فيه نقص، فـهونّا نوقف هنا، ونبدأ
+
+947
+01:33:38,110 --> 01:33:40,970
+في هذا السلايد الأسبوعي في المحاضرة القادمة،
+
+948
+01:33:40,970 --> 01:33:46,570
+إن شاء الله، في أسئلة؟ لحد الآن يعني الموضوع تمام،
+
+949
+01:33:46,570 --> 01:33:49,750
+إذا كانت في أسئلة يا دكاترة، بإمكانكم تسألوه سواء
+
+950
+01:33:49,750 --> 01:33:53,730
+بخصوص المحاضرة هذه أو المحاضرة الماضية كمان، إن شاء
+
+951
+01:33:53,730 --> 01:34:00,170
+الله، المرات القادمة راح نطلع على «Kaplan» وعلى
+
+952
+01:34:00,170 --> 01:34:05,890
+الـUSMLE، والله يعني في أشياء لسه ما أخذناها، بس إنه
+
+953
+01:34:05,890 --> 01:34:09,930
+الواحد يقعد يراجعهم مش غلط، وهيصير جزء من الإعداد
+
+954
+01:34:09,930 --> 01:34:16,690
+للامتحانات، إنه نراجعها يعني بإذن الله، بإذن الله
+
+955
+01:34:16,690 --> 01:34:21,890
+لأنه، لأنه يا دكتور يعني حتى توجيه لكلية إنه تم
+
+956
+01:34:21,890 --> 01:34:25,130
+اعتماد وإقرار امتحان «IPhONE Basic Science»، المهم
+
+957
+01:34:25,130 --> 01:34:30,630
+الواحد يكون فاهم المبدأ أو الشيء جيد، جيد، إن
+
+958
+01:34:30,630 --> 01:34:35,330
+الطلاب على اللي هو السياق تبع الامتحان من الآن
+
+959
+01:34:35,330 --> 01:34:41,070
+نبدأ نراجعها، بس ما بديش يعني، في أحيانًا إجابة
+
+960
+01:34:41,070 --> 01:34:46,190
+الأسئلة يمكن تكون أقدر على إنك مع نهاية الـ
+
+961
+01:34:46,190 --> 01:34:49,970
+«course» تدرسها، تكون مريت عليها يعني، بتكون أحيانًا
+
+962
+01:34:49,970 --> 01:34:54,150
+أن أنت الآن شغل أنت ما أخذته راح تأخذه بعدين، يعني
+
+963
+01:34:54,150 --> 01:35:00,130
+كمثال محدد لنوع مرض، ورأفي يعني مثلًا، فاهم عليّ؟
+
+964
+01:35:00,130 --> 01:35:04,270
+آه تمام، إن شاء الله، بإذن الله تعالى، الله يوفقكم،
+
+965
+01:35:04,270 --> 01:35:08,010
+نشوفكم الأسبوع القادم، إن شاء الله، يلا السلام
+
+966
+01:35:08,010 --> 01:35:09,010
+عليكم، يعطيك العافية دكتور
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/mDsVoXEA6Pk_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/mDsVoXEA6Pk_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..7fa25f1961d34fa04172c522b668e6df3107fcc1
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/mDsVoXEA6Pk_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2492, "start": 0.0, "end": 24.92, "text": "أو في خلايا الإنسان واللي بتحكم في الوراثة من خلال تحكمه في تكوين البروتين وشرحنا الأسس اللي عليها تغييرات الـ DNA والجينات بتأدي لتغير الصفات الوراثية بس كمان يعني اللي هو بدأنا نظهره أو بدأنا نتكلم عنه", "tokens": [10721, 2407, 8978, 16490, 15040, 25528, 33688, 1863, 3794, 7649, 4032, 6027, 20292, 39894, 5016, 24793, 8978, 2423, 13063, 5718, 104, 3660, 9154, 16490, 1211, 6027, 6055, 5016, 24793, 3224, 8978, 6055, 4117, 2407, 9957, 2423, 26890, 35473, 9957, 4032, 46309, 5016, 8315, 16247, 3794, 3794, 13672, 1829, 25894, 11296, 6055, 17082, 1829, 13546, 9307, 2423, 39184, 8272, 16070, 7435, 1829, 8315, 2655, 39894, 10721, 16254, 5296, 2655, 17082, 13546, 31767, 5172, 9307, 2423, 13063, 5718, 104, 10632, 4724, 3794, 9122, 2304, 7649, 37495, 22653, 13672, 1829, 31439, 47525, 10721, 8315, 8717, 19913, 3224, 2288, 3224, 34051, 47525, 10721, 8315, 8717, 2655, 4117, 19528, 18871, 3224], "avg_logprob": -0.09769275742713536, "compression_ratio": 1.8724489795918366, "no_speech_prob": 5.3822994232177734e-05, "words": [{"start": 0.0, "end": 0.76, "word": "أو", "probability": 0.7083740234375}, {"start": 0.76, "end": 0.94, "word": " في", "probability": 0.79931640625}, {"start": 0.94, "end": 1.3, "word": " خلايا", "probability": 0.9319661458333334}, {"start": 1.3, "end": 2.02, "word": " الإنسان", "probability": 0.9930419921875}, {"start": 2.02, "end": 2.76, "word": " واللي", "probability": 0.5017903645833334}, {"start": 2.76, "end": 3.26, "word": " بتحكم", "probability": 0.94189453125}, {"start": 3.26, "end": 3.4, "word": " في", "probability": 0.9638671875}, {"start": 3.4, "end": 4.16, "word": " الوراثة", "probability": 0.975}, {"start": 4.16, "end": 4.5, "word": " من", "probability": 0.908203125}, {"start": 4.5, "end": 5.14, "word": " خلال", "probability": 0.9954427083333334}, {"start": 5.14, "end": 6.46, "word": " تحكمه", "probability": 0.9683837890625}, {"start": 6.46, "end": 6.68, "word": " في", "probability": 0.96435546875}, {"start": 6.68, "end": 7.18, "word": " تكوين", "probability": 0.925048828125}, {"start": 7.18, "end": 8.0, "word": " البروتين", "probability": 0.874755859375}, {"start": 8.0, "end": 9.26, "word": " وشرحنا", "probability": 0.9404296875}, {"start": 9.26, "end": 10.52, "word": " الأسس", "probability": 0.9607747395833334}, {"start": 10.52, "end": 11.18, "word": " اللي", "probability": 0.98388671875}, {"start": 11.18, "end": 11.92, "word": " عليها", "probability": 0.92333984375}, {"start": 11.92, "end": 13.18, "word": " تغييرات", "probability": 0.9384765625}, {"start": 13.18, "end": 13.68, "word": " الـ", "probability": 0.99072265625}, {"start": 13.68, "end": 13.92, "word": " DNA", "probability": 0.435546875}, {"start": 13.92, "end": 14.98, "word": " والجينات", "probability": 0.8888671875}, {"start": 14.98, "end": 15.64, "word": " بتأدي", "probability": 0.708984375}, {"start": 15.64, "end": 16.42, "word": " لتغير", "probability": 0.92041015625}, 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"temperature": 1.0}, {"id": 52, "seek": 127715, "start": 1257.39, "end": 1277.15, "text": "فبمثل هذا الشكل يعني الواحد بيلاحظ إنه اللي قبل واللي بعد كله تماما زي الـReference Sequence ماصاش أي اختلاف فهذا نسميه SNP Single Nucleotide Polymorphism فبنيجي نقراها ثلاثات ثلاثات ثلاثات ثلاثات", "tokens": [5172, 3555, 2304, 12984, 1211, 23758, 25124, 28820, 37495, 22653, 2423, 14407, 24401, 4724, 1829, 15040, 5016, 19913, 36145, 3224, 13672, 1829, 12174, 36150, 4032, 6027, 20292, 39182, 28242, 3224, 46811, 10943, 995, 30767, 1829, 2423, 39184, 8524, 5158, 46859, 655, 19446, 9381, 33599, 36632, 1975, 46456, 15040, 5172, 6156, 3224, 15730, 8717, 38251, 1829, 3224, 13955, 47, 31248, 426, 1311, 306, 310, 482, 18553, 76, 18191, 1434, 6156, 3555, 1863, 1829, 7435, 1829, 8717, 4587, 23557, 11296, 38637, 1211, 5718, 104, 9307, 38637, 1211, 5718, 104, 9307, 38637, 1211, 5718, 104, 9307, 38637, 1211, 5718, 104, 9307], "avg_logprob": -0.18749999909689932, "compression_ratio": 1.57, "no_speech_prob": 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بالأخير هون بيسموه «mis-sense» هاي بتعتبروها «non-sense» أو إنه بتخرّب الـ الـ الـ DNA كقراءة بحيث إنه بيبطّل يسيل الـ protein اللي أنا مطلوب إني أعمله أحيانًا", "tokens": [6027, 20292, 39896, 20666, 10721, 9778, 13546, 8032, 11536, 4724, 1829, 38251, 2407, 3224, 4657, 45634, 12, 82, 1288, 5933, 8032, 47302, 39894, 34268, 26890, 2407, 11296, 4657, 30092, 12, 82, 1288, 5933, 34051, 36145, 3224, 39894, 34740, 11703, 3555, 2423, 39184, 2423, 39184, 2423, 39184, 8272, 9122, 4587, 2288, 16606, 3660, 4724, 5016, 1829, 12984, 36145, 3224, 4724, 1829, 3555, 9566, 11703, 1211, 7251, 3794, 26895, 2423, 39184, 7944, 13672, 1829, 41850, 3714, 9566, 1211, 37746, 36145, 1829, 5551, 25957, 43761, 5551, 5016, 1829, 7649, 14111, 995], "avg_logprob": -0.24859551901227972, "compression_ratio": 1.4866310160427807, "no_speech_prob": 3.039836883544922e-06, "words": [{"start": 2892.56, "end": 2892.92, "word": "اللي", "probability": 0.74169921875}, {"start": 2892.92, "end": 2893.04, "word": " هي", 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" بتخرّب", "probability": 0.865234375}, {"start": 2901.28, "end": 2902.52, "word": " الـ", "probability": 0.98193359375}, {"start": 2902.52, "end": 2903.42, "word": " الـ", "probability": 0.759033203125}, {"start": 2903.42, "end": 2904.72, "word": " الـ", "probability": 0.842041015625}, {"start": 2904.72, "end": 2904.9, "word": " DNA", "probability": 0.4892578125}, {"start": 2904.9, "end": 2906.68, "word": " كقراءة", "probability": 0.86318359375}, {"start": 2906.68, "end": 2907.06, "word": " بحيث", "probability": 0.9443359375}, {"start": 2907.06, "end": 2907.44, "word": " إنه", "probability": 0.839111328125}, {"start": 2907.44, "end": 2908.02, "word": " بيبطّل", "probability": 0.9168294270833334}, {"start": 2908.02, "end": 2908.32, "word": " يسيل", "probability": 0.7708333333333334}, {"start": 2908.32, "end": 2908.54, "word": " الـ", "probability": 0.821533203125}, {"start": 2908.54, "end": 2908.9, "word": " protein", "probability": 0.388427734375}, {"start": 2908.9, "end": 2909.18, "word": " اللي", "probability": 0.97705078125}, {"start": 2909.18, "end": 2909.44, "word": " أنا", "probability": 0.96484375}, {"start": 2909.44, "end": 2910.36, "word": " مطلوب", "probability": 0.84619140625}, {"start": 2910.36, "end": 2910.64, "word": " إني", "probability": 0.633056640625}, {"start": 2910.64, "end": 2911.34, "word": " أعمله", "probability": 0.9583333333333334}, {"start": 2911.34, "end": 2913.86, "word": " أحيانًا", "probability": 0.94287109375}], "temperature": 1.0}, {"id": 119, "seek": 294007, "start": 2916.19, "end": 2940.07, "text": "يعني هناك طرق متعددة لكيف بيصير الـ Deletion أو كيف بيصير الـ Insertion أو كيف شو اللي بيصير عندنا وهذه أمثلة يعني جيد الواحد يعني يكون على الطلاع عليها أو على الأقل حتى يحاول يقرأ بعدين عنها يعني يكون مستوعب شو الكلام اللي هو", "tokens": [40228, 22653, 34105, 4117, 23032, 2288, 4587, 44650, 22488, 41891, 5296, 4117, 33911, 4724, 1829, 9381, 13546, 2423, 39184, 5831, 302, 313, 34051, 9122, 33911, 4724, 1829, 9381, 13546, 2423, 39184, 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اللي", "probability": 0.983154296875}, {"start": 2923.59, "end": 2924.01, "word": " بيصير", "probability": 0.9871826171875}, {"start": 2924.01, "end": 2924.49, "word": " عندنا", "probability": 0.827392578125}, {"start": 2924.49, "end": 2925.89, "word": " وهذه", "probability": 0.634521484375}, {"start": 2925.89, "end": 2926.53, "word": " أمثلة", "probability": 0.96142578125}, {"start": 2926.53, "end": 2927.37, "word": " يعني", "probability": 0.92138671875}, {"start": 2927.37, "end": 2930.39, "word": " جيد", "probability": 0.72509765625}, {"start": 2930.39, "end": 2930.91, "word": " الواحد", "probability": 0.96484375}, {"start": 2930.91, "end": 2931.69, "word": " يعني", "probability": 0.752685546875}, {"start": 2931.69, "end": 2931.97, "word": " يكون", "probability": 0.987548828125}, {"start": 2931.97, "end": 2932.29, "word": " على", "probability": 0.67919921875}, {"start": 2932.29, "end": 2932.77, "word": " الطلاع", "probability": 0.6991373697916666}, {"start": 2932.77, "end": 2933.11, "word": " عليها", "probability": 0.979248046875}, {"start": 2933.11, "end": 2933.25, "word": " أو", "probability": 0.947265625}, {"start": 2933.25, "end": 2933.39, "word": " على", "probability": 0.97265625}, {"start": 2933.39, "end": 2933.63, "word": " الأقل", "probability": 0.7757975260416666}, {"start": 2933.63, "end": 2934.01, "word": " حتى", "probability": 0.95654296875}, {"start": 2934.01, "end": 2934.85, "word": " يحاول", "probability": 0.98779296875}, {"start": 2934.85, "end": 2935.41, "word": " يقرأ", "probability": 0.88671875}, {"start": 2935.41, "end": 2936.35, "word": " بعدين", "probability": 0.882568359375}, {"start": 2936.35, "end": 2937.79, "word": " عنها", "probability": 0.99658203125}, {"start": 2937.79, "end": 2938.23, "word": " يعني", "probability": 0.91748046875}, {"start": 2938.23, "end": 2938.61, "word": " يكون", "probability": 0.989501953125}, {"start": 2938.61, "end": 2939.35, "word": " مستوعب", "probability": 0.8692626953125}, {"start": 2939.35, "end": 2939.47, 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Intro on 1، 2، 3، لحد 21، 22، وبعدين في عندي Point ثانية عادة بتعمل مشكلة، وبعدين الـ23، هيك الأصل ينقرأ، هيك الأصل يكون طبيعي، فنتيجة الـLoop هذا اللي بحدث، فبصير عندي أنه بدل ما هو يبدأ بواحد، بيبدأ 22، 21، بقراه هيك، وبعدين 23 آخر شيء،", "tokens": [37746, 44510, 10721, 2423, 39184, 47406, 322, 502, 12399, 568, 12399, 805, 12399, 5296, 24401, 5080, 12399, 5853, 12399, 46599, 22488, 9957, 8978, 18871, 16254, 12387, 38637, 7649, 10632, 6225, 18513, 3660, 39894, 25957, 1211, 37893, 28820, 3660, 12399, 46599, 22488, 9957, 2423, 39184, 9356, 12399, 39896, 4117, 16247, 36520, 7251, 1863, 4587, 2288, 10721, 12399, 39896, 4117, 16247, 36520, 7251, 30544, 23032, 21292, 3615, 1829, 12399, 6156, 29399, 1829, 7435, 3660, 2423, 39184, 43, 15812, 23758, 13672, 1829, 4724, 24401, 12984, 12399, 6156, 3555, 9381, 13546, 18871, 16254, 14739, 3224, 47525, 1211, 19446, 31439, 7251, 44510, 10721, 4724, 14407, 24401, 12399, 4724, 1829, 44510, 10721, 5853, 12399, 5080, 12399, 4724, 4587, 23557, 3224, 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"probability": 0.965576171875}, {"start": 5415.72, "end": 5415.72, "word": " «سنترومير»،", "probability": 0.968994140625}, {"start": 5415.72, "end": 5415.76, "word": " «سنترومير»،", "probability": 0.9713134765625}, {"start": 5415.76, "end": 5415.76, "word": " «سنترومير»،", "probability": 0.972900390625}, {"start": 5415.76, "end": 5416.14, "word": " «سنترومير»،", "probability": 0.97369384765625}, {"start": 5416.14, "end": 5416.56, "word": " «سنترومير»،", "probability": 0.97418212890625}, {"start": 5416.56, "end": 5416.78, "word": " «سنترومير»،", "probability": 0.974365234375}, {"start": 5416.78, "end": 5416.86, "word": " «سنترومير»،", "probability": 0.974365234375}, {"start": 5416.86, "end": 5416.88, "word": " «سنترومير»،", "probability": 0.9742431640625}, {"start": 5416.88, "end": 5418.62, "word": " «سنترومير»،", "probability": 0.97381591796875}, {"start": 5418.62, "end": 5419.4, "word": " «سنترومير»،", "probability": 0.973388671875}, {"start": 5419.4, "end": 5419.56, "word": " «سنترومير»،", "probability": 0.97320556640625}, {"start": 5419.56, "end": 5420.06, "word": " «سنترومير»،", "probability": 0.97296142578125}, {"start": 5420.06, "end": 5422.78, "word": " «سنترومير»،", "probability": 0.972412109375}, {"start": 5422.78, "end": 5424.36, "word": " «سنترومير»،", "probability": 0.970703125}, {"start": 5424.36, "end": 5430.12, "word": " «سنترومير", "probability": 0.9736328125}], "temperature": 1.0}, {"id": 212, "seek": 545317, "start": 5430.85, "end": 5453.17, "text": "الـ Short Arm of Chromosome يعني هذه المصطلحات اللي «Gain» أو «Loss» أو «Mosaicism» المزاييك يعني إنه فيه أكتر من شكل في نفس الإنسان، ماشي؟ فهدولة و الـ Translocation و الـ Robert Stahnel Translocation Ring Chromosomes", "tokens": [6027, 39184, 16881, 11893, 295, 1721, 40934, 423, 37495, 22653, 29538, 9673, 9381, 9566, 1211, 5016, 9307, 13672, 1829, 4657, 38, 491, 5933, 34051, 4657, 43, 772, 5933, 34051, 4657, 44, 6447, 26356, 5933, 9673, 11622, 47302, 1829, 4117, 37495, 22653, 36145, 3224, 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{"start": 5433.43, "end": 5434.53, "word": " المصطلحات", "probability": 0.9854329427083334}, {"start": 5434.53, "end": 5435.91, "word": " اللي", "probability": 0.853759765625}, {"start": 5435.91, "end": 5437.47, "word": " «Gain»", "probability": 0.54833984375}, {"start": 5437.47, "end": 5437.65, "word": " أو", "probability": 0.96875}, {"start": 5437.65, "end": 5438.21, "word": " «Loss»", "probability": 0.981689453125}, {"start": 5438.21, "end": 5438.39, "word": " أو", "probability": 0.9814453125}, {"start": 5438.39, "end": 5440.33, "word": " «Mosaicism»", "probability": 0.92265625}, {"start": 5440.33, "end": 5441.31, "word": " المزاييك", "probability": 0.589404296875}, {"start": 5441.31, "end": 5441.61, "word": " يعني", "probability": 0.96728515625}, {"start": 5441.61, "end": 5442.01, "word": " إنه", "probability": 0.714111328125}, {"start": 5442.01, "end": 5442.21, "word": " فيه", "probability": 0.89013671875}, {"start": 5442.21, "end": 5442.51, "word": " أكتر", "probability": 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"probability": 0.9296875}, {"start": 5481.82, "end": 5482.44, "word": " القطعة", "probability": 0.9694010416666666}], "temperature": 1.0}, {"id": 214, "seek": 550123, "start": 5483.65, "end": 5501.23, "text": "ويعني هنا هم عاملين «Karyotype» على «Fish» على «Microarray Study» بتلاقي أحيانًا في دراسة حالة معينة بيحطلك رسمات فيها أشياء زي هيك، ماشي", "tokens": [2407, 40228, 22653, 34105, 8032, 2304, 6225, 10943, 1211, 9957, 4657, 42, 822, 13108, 5933, 15844, 4657, 37, 742, 5933, 15844, 4657, 48831, 340, 2284, 320, 27039, 5933, 39894, 15040, 38436, 5551, 5016, 1829, 7649, 14111, 995, 8978, 11778, 23557, 3794, 3660, 11331, 6027, 3660, 20449, 9957, 3660, 4724, 1829, 5016, 9566, 23275, 12602, 38251, 9307, 8978, 11296, 5551, 8592, 1829, 16606, 30767, 1829, 39896, 4117, 12399, 3714, 33599, 1829], "avg_logprob": -0.2632042261916147, "compression_ratio": 1.2873563218390804, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 5483.65, "end": 5484.97, "word": "ويعني", "probability": 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في", "probability": 0.9013671875}, {"start": 5495.55, "end": 5496.09, "word": " دراسة", "probability": 0.991455078125}, {"start": 5496.09, "end": 5496.45, "word": " حالة", "probability": 0.9733072916666666}, {"start": 5496.45, "end": 5497.09, "word": " معينة", "probability": 0.9943033854166666}, {"start": 5497.09, "end": 5497.73, "word": " بيحطلك", "probability": 0.828125}, {"start": 5497.73, "end": 5498.25, "word": " رسمات", "probability": 0.9410807291666666}, {"start": 5498.25, "end": 5498.49, "word": " فيها", "probability": 0.956298828125}, {"start": 5498.49, "end": 5498.83, "word": " أشياء", "probability": 0.9942626953125}, {"start": 5498.83, "end": 5499.03, "word": " زي", "probability": 0.982666015625}, {"start": 5499.03, "end": 5500.71, "word": " هيك،", "probability": 0.592041015625}, {"start": 5500.71, "end": 5501.23, "word": " ماشي", "probability": 0.9404296875}], "temperature": 1.0}, {"id": 215, "seek": 553393, "start": 5504.89, "end": 5533.93, "text": "حكينا في أحيانًا يصير عندي الـNon-disjunction هنا حاطين أو عملية الـTranslocation أو Isochromosome أو Troperstein Translocation أو كذا، Duplication يعني هدولة كلهم اختلالات على مستوى الـDNA ممكن الانتباه إلها من خلال الـKaryotype", "tokens": [5016, 4117, 1829, 8315, 8978, 5551, 5016, 1829, 7649, 14111, 995, 7251, 9381, 13546, 18871, 16254, 2423, 39184, 47914, 12, 13731, 10010, 882, 34105, 11331, 41193, 9957, 34051, 6225, 42213, 10632, 2423, 39184, 33339, 5842, 399, 34051, 286, 539, 339, 4397, 329, 423, 34051, 19406, 610, 9089, 6531, 5842, 399, 34051, 9122, 15730, 12399, 5153, 4770, 399, 37495, 22653, 8032, 3215, 12610, 3660, 28242, 16095, 1975, 46456, 1211, 6027, 9307, 15844, 3714, 14851, 2407, 7578, 2423, 39184, 35, 5321, 3714, 43020, 2423, 7649, 2655, 3555, 40294, 11933, 1211, 11296, 9154, 16490, 1211, 6027, 2423, 39184, 42, 822, 13108], "avg_logprob": -0.1949179359156676, "compression_ratio": 1.4303797468354431, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 5504.89, "end": 5505.59, 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{"start": 5514.05, "end": 5515.17, "word": " أو", "probability": 0.9833984375}, {"start": 5515.17, "end": 5517.09, "word": " Isochromosome", "probability": 0.8120930989583334}, {"start": 5517.09, "end": 5517.27, "word": " أو", "probability": 0.97412109375}, {"start": 5517.27, "end": 5517.91, "word": " Troperstein", "probability": 0.3250325520833333}, {"start": 5517.91, "end": 5518.87, "word": " Translocation", "probability": 0.8445638020833334}, {"start": 5518.87, "end": 5519.11, "word": " أو", "probability": 0.98046875}, {"start": 5519.11, "end": 5520.37, "word": " كذا،", "probability": 0.7743326822916666}, {"start": 5520.37, "end": 5521.29, "word": " Duplication", "probability": 0.9327799479166666}, {"start": 5521.29, "end": 5522.73, "word": " يعني", "probability": 0.81689453125}, {"start": 5522.73, "end": 5523.11, "word": " هدولة", "probability": 0.7757568359375}, {"start": 5523.11, "end": 5523.37, "word": " كلهم", "probability": 0.75}, {"start": 5523.37, "end": 5524.37, "word": " 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حتى توجهه لكلية إنه تم اعتماد وإقرار امتحان «IPhone Basic Science» المهم الواحد يكون فاهم المبدأ أو الشيء جيد، جيد إن الطلاب على اللي هو السياحة تبع الامتحان من الآن نبدأ نراجعها، بس بديش يعني في أحيانًا إجابة الأسئلة يمكن", "tokens": [3555, 28814, 8848, 1863, 21984, 12399, 4724, 28814, 8848, 1863, 21984, 5296, 33456, 3224, 12399, 5296, 33456, 3224, 35186, 11778, 4117, 2655, 13063, 37495, 22653, 11331, 49975, 33427, 7435, 3224, 3224, 5296, 28820, 10632, 36145, 3224, 46811, 1975, 34268, 15042, 3215, 4032, 28814, 4587, 2288, 9640, 1975, 2304, 2655, 5016, 7649, 4657, 9139, 6487, 31598, 8976, 5933, 9673, 16095, 2423, 14407, 24401, 7251, 30544, 6156, 995, 16095, 9673, 44510, 10721, 34051, 25124, 1829, 38207, 10874, 25708, 12399, 10874, 25708, 36145, 41950, 15040, 3555, 15844, 13672, 1829, 31439, 21136, 25528, 5016, 3660, 6055, 3555, 3615, 2423, 10943, 2655, 5016, 7649, 9154, 6024, 48506, 8717, 44510, 10721, 8717, 2288, 26108, 3615, 11296, 12399, 4724, 3794, 4724, 16254, 8592, 37495, 22653, 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اللي", "probability": 0.90185546875}, {"start": 5672.85, "end": 5673.11, "word": " هو", "probability": 0.958984375}, {"start": 5673.11, "end": 5673.71, "word": " السياحة", "probability": 0.8780517578125}, {"start": 5673.71, "end": 5673.93, "word": " تبع", "probability": 0.7403157552083334}, {"start": 5673.93, "end": 5674.39, "word": " الامتحان", "probability": 0.96494140625}, {"start": 5674.39, "end": 5674.53, "word": " من", "probability": 0.96728515625}, {"start": 5674.53, "end": 5675.33, "word": " الآن", "probability": 0.771240234375}, {"start": 5675.33, "end": 5676.01, "word": " نبدأ", "probability": 0.9425455729166666}, {"start": 5676.01, "end": 5677.59, "word": " نراجعها،", "probability": 0.7952473958333334}, {"start": 5677.59, "end": 5677.73, "word": " بس", "probability": 0.990966796875}, {"start": 5677.73, "end": 5678.35, "word": " بديش", "probability": 0.7948404947916666}, {"start": 5678.35, "end": 5678.83, "word": " يعني", "probability": 0.9365234375}, {"start": 5678.83, 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5689.15, "word": " يعني", "probability": 0.927734375}, {"start": 5689.15, "end": 5689.53, "word": " بتكون", "probability": 0.917724609375}, {"start": 5689.53, "end": 5689.97, "word": " أحيانًا", "probability": 0.9527994791666666}, {"start": 5689.97, "end": 5690.13, "word": " أن", "probability": 0.79052734375}, {"start": 5690.13, "end": 5690.23, "word": " أنت", "probability": 0.6405029296875}, {"start": 5690.23, "end": 5690.93, "word": " الآن", "probability": 0.59814453125}, {"start": 5690.93, "end": 5691.67, "word": " شغل", "probability": 0.9039713541666666}, {"start": 5691.67, "end": 5691.99, "word": " أنت", "probability": 0.772216796875}, {"start": 5691.99, "end": 5692.21, "word": " ما", "probability": 0.85107421875}, {"start": 5692.21, "end": 5692.87, "word": " أخدت", "probability": 0.8485107421875}, {"start": 5692.87, "end": 5693.05, "word": " راح", "probability": 0.7103271484375}, {"start": 5693.05, "end": 5693.41, "word": " تاخده", "probability": 0.8929443359375}, {"start": 5693.41, "end": 5693.89, "word": " بعدين", "probability": 0.877197265625}, {"start": 5693.89, "end": 5694.15, "word": " يعني", "probability": 0.871826171875}, {"start": 5694.15, "end": 5695.21, "word": " كمثال", "probability": 0.9793701171875}, {"start": 5695.21, "end": 5696.77, "word": " محدد", "probability": 0.98974609375}, {"start": 5696.77, "end": 5697.25, "word": " لنوع", "probability": 0.9833984375}, {"start": 5697.25, "end": 5697.59, "word": " مرض", "probability": 0.98681640625}, {"start": 5697.59, "end": 5698.09, "word": " ورافي", "probability": 0.592529296875}, {"start": 5698.09, "end": 5698.31, "word": " يعني", "probability": 0.77294921875}, {"start": 5698.31, "end": 5699.25, "word": " مثلًا،", "probability": 0.782861328125}, {"start": 5699.25, "end": 5699.39, "word": " فاهم", "probability": 0.804443359375}, {"start": 5699.39, "end": 5700.13, "word": " عليك؟", "probability": 0.7867838541666666}, {"start": 5700.13, "end": 5701.23, "word": " آه", "probability": 0.7470703125}, {"start": 5701.23, "end": 5702.05, "word": " تمام،", "probability": 0.6295572916666666}, {"start": 5702.05, "end": 5702.09, "word": " إن", "probability": 0.59326171875}, {"start": 5702.09, "end": 5702.23, "word": " شاء", "probability": 0.984619140625}, {"start": 5702.23, "end": 5702.41, "word": " الله،", "probability": 0.799072265625}, {"start": 5702.41, "end": 5702.75, "word": " بإذن", "probability": 0.9554443359375}, {"start": 5702.75, "end": 5702.93, "word": " الله", "probability": 0.93115234375}, {"start": 5702.93, "end": 5703.29, "word": " تعالى", "probability": 0.9801432291666666}, {"start": 5703.29, "end": 5703.53, "word": " الله", "probability": 0.7294921875}, {"start": 5703.53, "end": 5704.27, "word": " يوفقكم،", "probability": 0.955078125}, {"start": 5704.27, "end": 5704.97, "word": " نشوفكم", "probability": 0.927978515625}, {"start": 5704.97, "end": 5705.77, "word": " الأسبوع", "probability": 0.83837890625}, {"start": 5705.77, "end": 5706.35, "word": " القادم،", "probability": 0.86798095703125}, {"start": 5706.35, "end": 5706.45, "word": " إن", "probability": 0.96875}, {"start": 5706.45, "end": 5706.59, "word": " شاء", "probability": 0.992431640625}, {"start": 5706.59, "end": 5707.43, "word": " الله،", "probability": 0.604736328125}, {"start": 5707.43, "end": 5707.65, "word": " يلا", "probability": 0.670654296875}, {"start": 5707.65, "end": 5708.01, "word": " السلام", "probability": 0.8056640625}, {"start": 5708.01, "end": 5708.07, "word": " عليكم", "probability": 0.70361328125}, {"start": 5708.07, "end": 5708.41, "word": " يعطيك", "probability": 0.6561126708984375}, {"start": 5708.41, "end": 5708.71, "word": " العافية", "probability": 0.9070638020833334}, {"start": 5708.71, "end": 5709.01, "word": " دكتور", "probability": 0.73712158203125}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 5713.6878125, "duration_after_vad": 5607.135968750021}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/nm86yn-CITA.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/nm86yn-CITA.srt
new file mode 100644
index 0000000000000000000000000000000000000000..192d5c814dcfeded28ce03c3f65913e431d49de2
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/nm86yn-CITA.srt
@@ -0,0 +1,695 @@
+
+1
+00:00:00,000 --> 00:00:08,840
+بالنسبة لـ «عشان نربط الأمور ببعض» ، أتأمل الجدول
+
+2
+00:00:08,840 --> 00:00:15,240
+هذا يكون موجود، شايفينه يعني
+
+3
+00:00:15,240 --> 00:00:18,540
+كمرض،
+
+4
+00:00:18,540 --> 00:00:22,340
+وكنوع
+
+5
+00:00:22,340 --> 00:00:26,600
+من الأمراض الوراثية: الـsickle cell والثلاسيميا،
+
+6
+00:00:26,600 --> 00:00:30,760
+أنيميا البحر الأبيض المتوسط والأنيميا المنجلية
+
+7
+00:00:30,760 --> 00:00:36,540
+كأمراض دم، من المواضيع اللي يعني مفهومة بشكل كبير
+
+8
+00:00:36,540 --> 00:00:43,340
+وفيه جوانب معروفة كثيرة، وحالة شائعة بسبب الظروف
+
+9
+00:00:43,340 --> 00:00:49,200
+الشيء اللي كان ناقص من الجداول والـFigures اللي
+
+10
+00:00:49,200 --> 00:00:53,560
+حطيناها في المحاضرة اللي فاتت، اللي هو الجدول
+
+11
+00:00:53,560 --> 00:00:55,120
+هذا، وأعتبره كمان مهم
+
+12
+00:00:57,850 --> 00:01:04,490
+اتفقنا على أنه بالنسبة للـ «هيموغلوبين» فيه عندنا
+
+13
+00:01:04,490 --> 00:01:12,970
+أربعة، عندنا أربع copies
+
+14
+00:01:12,970 --> 00:01:16,630
+of the Alpha gene، وعندنا two copies of the Beta
+
+15
+00:01:16,630 --> 00:01:24,970
+chain gene، وبالنسبة للـ «ألفا»
+
+16
+00:01:24,970 --> 00:01:31,710
+في الغالب هو اللي بيعطينا ثلاسيميا، وبتكون عن
+
+17
+00:01:31,710 --> 00:01:36,710
+طريق الـ deletions، الـ Beta-thalassemia ممكنة برضه
+
+18
+00:01:36,710 --> 00:01:40,630
+بس الأكثر بالنسبة للـ Beta-chain أنه يكون أنها
+
+19
+00:01:40,630 --> 00:01:46,310
+qualitative hemoglobinopathies، زي السكل والـ other
+
+20
+00:01:46,310 --> 00:01:51,590
+types of hemoglobin، وحكينا عن الـ genetics تبعتهم
+
+21
+00:01:52,340 --> 00:01:59,340
+بحب أذكر  بإيه، اللي هو بالنسبة
+
+22
+00:01:59,340 --> 00:02:05,380
+للـ «ألفا ثلاسيميا»،  بالنسبة لإنه عندنا أربعة
+
+23
+00:02:05,380 --> 00:02:09,780
+copies of the Alpha genes، two copies in each
+
+24
+00:02:09,780 --> 00:02:14,280
+chromosome، فعندي أربعة، لما يكون عندي الأربعة
+
+25
+00:02:14,280 --> 00:02:20,040
+بيكون عندي functional طبعاً Alpha Alpha Alpha
+
+26
+00:02:20,040 --> 00:02:24,890
+Alpha، بيكون إن الـ Alpha Chain Production 100% من
+
+27
+00:02:24,890 --> 00:02:30,950
+القيمة، لما يكون عندي ثلاثة مقاطع بيكون عندي Silent
+
+28
+00:02:30,950 --> 00:02:37,230
+Carrier، يعني غير أنه Carrier، يعني Silent، يعني It
+
+29
+00:02:37,230 --> 00:02:43,530
+looks normal، فبالنسبة إن الـ
+
+30
+00:02:43,530 --> 00:02:50,060
+Alpha Chain Production حوالي 75%، ويكون عندي ثلاثة
+
+31
+00:02:50,060 --> 00:02:55,320
+مقاطع، تمشي أكثر على إنه في عندي deletions، دليشنز
+
+32
+00:02:55,320 --> 00:03:02,560
+بمعنى جين، عكس
+
+33
+00:03:02,560 --> 00:03:08,040
+مثلاً الـ Sickle cell، الجين بيشتغل ويطلع بروتين بتاع
+
+34
+00:03:08,040 --> 00:03:13,480
+الـ Chain بس Abnormal، هنا لأ، بيكون معناته بس إنه
+
+35
+00:03:13,480 --> 00:03:17,540
+كمية الـ Hemoglobin اللي بتطلع أو الـ Alpha Chain
+
+36
+00:03:17,960 --> 00:03:23,340
+في الحالة هذه بتكون الـ Decrease، لما يكون عندي Two
+
+37
+00:03:23,340 --> 00:03:27,600
+copies deleted
+
+38
+00:03:27,600 --> 00:03:30,820
+لما يكون عندي Two copies بيكون الـ Alpha
+
+39
+00:03:30,820 --> 00:03:36,060
+-thalassemia trait، هذا اللي شائع، وبتلاقيه بيعطينا
+
+40
+00:03:36,060 --> 00:03:41,340
+شوية Mild Anemia، وMicrocytosis، الـ RDW Red Cell
+
+41
+00:03:41,340 --> 00:03:44,860
+Distribution اللي بيكون Normal، ويكون عندي Two
+
+42
+00:03:44,860 --> 00:03:49,150
+copies بس اللي شغالة بهذه الطريقة، واحدة على كل
+
+43
+00:03:49,150 --> 00:03:52,590
+كروموزوم، أو واحدة على كروموزوم طبيعي تماماً، أو
+
+44
+00:03:52,590 --> 00:04:01,650
+اثنتان على آخر كروموزوم، ويكون 50% من المشكلة موجودة
+
+45
+00:04:01,650 --> 00:04:08,970
+في، إذا عندنا ثلاثة مقاطع أُخرجت، بيصير عندي ما هو الـ
+
+46
+00:04:08,970 --> 00:04:13,150
+«ثلاسيميا» الـ Disease، «ثلاسيميا» الـ «ثلاسيميا»
+
+47
+00:04:13,150 --> 00:04:13,170
+الـ «ثلاسيميا» الـ «ثلاسيميا» الـ «ثلاسيميا» الـ
+
+48
+00:04:13,170 --> 00:04:13,250
+«ثلاسيميا» الـ «ثلاسيميا» الـ «ثلاسيميا» الـ
+
+49
+00:04:13,250 --> 00:04:13,350
+«ثلاسيميا» الـ «ثلاسيميا» الـ «ثلاسيميا» الـ
+
+50
+00:04:13,350 --> 00:04:13,470
+«ثلاسيميا» الـ «ثلاسيميا» الـ «ثلاسيميا» الـ
+
+51
+00:04:13,470 --> 00:04:25,070
+«ثلاسيميا» الـ «ثلاسيميا» الـ «ثلاسيميا»
+
+52
+00:04:25,070 --> 00:04:34,010
+الـ «ثلاسيميا» الـ «ثلاسيميا»
+
+53
+00:04:34,010 --> 00:04:37,980
+الـ «ثلاسيميا» الـ «ثلا  إذا عندي أربعة copies
+
+54
+00:04:37,980 --> 00:04:43,360
+removed، بيسموه الـ Hemoglobin Parts أو High Drops
+
+55
+00:04:43,360 --> 00:04:47,300
+in Thal، أو Homozygous Alpha Thalassemia، بيكون
+
+56
+00:04:47,300 --> 00:04:54,240
+Very Severe، الجنين ما بيعيش، فبتأمل
+
+57
+00:04:54,240 --> 00:05:00,540
+أنه يكون  غطينا الحالات
+
+58
+00:05:00,540 --> 00:05:01,680
+اللي بيكون فيها
+
+59
+00:05:04,260 --> 00:05:12,460
+وهذه أول مجموعة من الأمراض الوراثية اللي راح نغطيها
+
+60
+00:05:12,460 --> 00:05:18,720
+في أسئلة؟
+
+61
+00:05:18,720 --> 00:05:21,240
+أسئلة للمرحلة الحالية؟
+
+62
+00:05:32,280 --> 00:05:47,740
+الآن بالنسبة لـ «دكتور» من «كريم»، تفضل «كريم»
+
+63
+00:05:47,740 --> 00:05:52,100
+إن شاء الله، تكون تبعت موضوع
+
+64
+00:05:53,700 --> 00:05:58,680
+لما حطينا الـ «A» والـ «B» والـ «O» هيموجلوبينات
+
+65
+00:05:58,680 --> 00:06:04,960
+كيف حسبناها؟ حسبناها يعني، أسهل طريقة أن نطلعها
+
+66
+00:06:04,960 --> 00:06:14,730
+للأسف الأرقام اللي حطيتها كانت يعني أرقام… شو اسمه؟
+
+67
+00:06:14,730 --> 00:06:22,990
+يعني خطأ، بس الفكرة إن الـ «O» بتطلع منها يعني الـ
+
+68
+00:06:22,990 --> 00:06:28,670
+«O incidence» بتطلع منها، بتأخذ الجذر تبعها، تعطينا
+
+69
+00:06:28,670 --> 00:06:37,690
+الـ «frequency» تبعت الـ «O»، الـ «O» group، والبقية
+
+70
+00:06:37,690 --> 00:06:39,790
+بيكونوا الـ «O»
+
+71
+00:06:44,380 --> 00:06:50,140
+عشان الـ «O» بتكون قليل متنحي، فطلعته لحاله
+
+72
+00:06:50,140 --> 00:06:51,640
+«O» بيطلع لحاله «O» بيطلع لحاله «O» بيطلع لحاله
+
+73
+00:06:51,640 --> 00:06:55,960
+«O» بيطلع لحاله «O»
+
+74
+00:06:55,960 --> 00:06:56,280
+بيطلع لحاله «O» بيطلع لحاله «O» بيطلع لحاله «O»
+
+75
+00:06:56,280 --> 00:06:56,540
+بيطلع لحاله «O» بيطلع لحاله «O» بيطلع لحاله «O»
+
+76
+00:06:56,540 --> 00:07:00,420
+بيطلع لحاله «O» بيطلع لحاله «O» بيطلع لحاله «O»
+
+77
+00:07:00,420 --> 00:07:08,380
+بيطلع لحاله «O» بيطلع
+
+78
+00:07:08,380 --> 00:07:14,350
+لحساب  الـ «A» والـ «B» frequency، الاثنين مع بعض
+
+79
+00:07:14,350 --> 00:07:20,170
+ولما يكون الواحد عنده «A» «B» blood group، معناته
+
+80
+00:07:20,170 --> 00:07:33,070
+اثنين شغلات، عندك معادلتين، يعني عندك أنه الـ «A»
+
+81
+00:07:33,070 --> 00:07:35,410
+تربيع، زائد «B» تربيع، زائد 2 «A» «B»
+
+82
+00:07:35,410 --> 00:07:35,690
+يستخدم الـ «A» يستخدم الـ «B» يستخدم الـ «A»
+
+83
+00:07:35,690 --> 00:07:37,410
+يستخدم الـ «B» يستخدم الـ «A» يستخدم الـ «B»
+
+84
+00:07:37,410 --> 00:07:37,490
+يستخدم الـ «A» يستخدم الـ «B» يستخدم الـ «A»
+
+85
+00:07:37,490 --> 00:07:41,690
+يستخدم الـ «B»، وإيه إذا كان واحد ما جاب الـ «Control»
+
+86
+00:07:41,690 --> 00:07:51,230
+فبقى الـ «B»؟ آه، فعندك معادلتين، يعني الـ «AB Rate»
+
+87
+00:07:51,230 --> 00:07:55,950
+هو يمثل الـ frequency تبع الأليل تبع الـ «A»، في
+
+88
+00:07:55,950 --> 00:07:59,510
+الـ frequency تبع الأليل تبع الـ «B»، لأن هذا حصل
+
+89
+00:07:59,510 --> 00:08:08,350
+ضربهم، فمعناته كيف؟ فزائد أنه واحد ناقص الـ
+
+90
+00:08:08,350 --> 00:08:14,310
+Frequency تبع الـ O، تعطينا رقم يمثل الـ Frequency
+
+91
+00:08:14,310 --> 00:08:18,290
+تبع الـ A زائد الـ Frequency تبع الـ B، فعندك
+
+92
+00:08:18,290 --> 00:08:22,710
+معادلتين بمجهولين بتحلهم، بتطلع لك شو النتيجة،
+
+93
+00:08:22,710 --> 00:08:29,030
+فمعناته يا؟ آه، شو السؤال الثاني يا كريم؟ اللي بيكون
+
+94
+00:08:29,030 --> 00:08:33,050
+عنده نقص في أربع سلاسل ألفا، في الحالات اللي جابها،
+
+95
+00:08:33,050 --> 00:08:37,230
+بتموت في مرحلة الجنين ولا بيبقى عايش؟ ‏-اللي هو
+
+96
+00:08:37,230 --> 00:08:41,730
+الـHydrops Fetalis ‏-في الجنين، كده بتقول شوية،
+
+97
+00:08:41,730 --> 00:08:46,790
+صحيح ‏-الـHydrops Fetalis، أربعة deletions، very
+
+98
+00:08:46,790 --> 00:08:51,970
+severe، نيوناتالي، يعني مش نيوناتالي، in vitro they
+
+99
+00:08:51,970 --> 00:08:57,650
+will die، يعني بيموت وهو في بطن أمه، الـ High Drops
+
+100
+00:08:57,650 --> 00:09:03,950
+Fetalis، هي حالة بيصير فيها يعني زي أنيميا شديدة في
+
+101
+00:09:03,950 --> 00:09:11,570
+الجنين، فبالتالي بيموت، شايف علي؟ بالنسبة للـ High
+
+102
+00:09:11,570 --> 00:09:17,650
+Drops Fetalis، السبب الثاني اللي هو الـ Rh
+
+103
+00:09:17,650 --> 00:09:18,930
+Incompatibility
+
+104
+00:09:20,700 --> 00:09:24,900
+لما يصير أنه بعد الأول جنين وثاني جنين، إذا ما
+
+105
+00:09:24,900 --> 00:09:30,360
+اتدخلوا الأطباء، وصار الـ Rh-incompatibility، راح يصير
+
+106
+00:09:30,360 --> 00:09:36,880
+أنه بعد هيك كل ما تحمل يموت الجنين، لسبب أنه فيه
+
+107
+00:09:36,880 --> 00:09:42,300
+antibodies، بتدخل بتكسر الـ Red blood cells، وبالتالي
+
+108
+00:09:42,300 --> 00:09:49,220
+بتخلي الجنين يموت، فالـ «هيدروبس» في «ثالاسيميا» فيه
+
+109
+00:09:49,220 --> 00:09:55,120
+مثلاً الـ «ثلاسيميا» يعني Alpha-thalassemia major
+
+110
+00:09:55,120 --> 00:10:01,720
+اللي هي four deletions، أو الـ parts، hemoglobin
+
+111
+00:10:01,720 --> 00:10:07,720
+parts، أو ما هو اسمه؟ اللي هو مثلاً الـimmune
+
+112
+00:10:07,720 --> 00:10:09,120
+hemolytic anemia
+
+113
+00:10:11,460 --> 00:10:19,780
+الـ Rh-incompatibility، إذا ما عُولجت بالشكل الصحيح
+
+114
+00:10:19,780 --> 00:10:24,320
+هدول الحالتين بيعملوا إيش؟  بنقوله «high-drops
+
+115
+00:10:24,320 --> 00:10:32,520
+fetalis»، «Severe Iron» أو «Severe Anemia» في الوقت
+
+116
+00:10:32,520 --> 00:10:37,280
+الـ «فيتال»، ويكونوا مرتبطين بالموت
+
+117
+00:10:40,920 --> 00:10:45,780
+في سؤال؟ يعني حتى الثلاثة برضه ممكن يكون مميز في
+
+118
+00:10:45,780 --> 00:10:50,700
+الجانب إيش هو؟ حتى لو كان عنده نقص ثلاثة، ثلاثة،
+
+119
+00:10:50,700 --> 00:10:53,880
+ثلاثة، ثلاثة، ثلاثة، ثلاثة، ثلاثة، ثلاثة، ثلاثة،
+
+120
+00:10:53,880 --> 00:10:55,320
+ثلاثة، ثلاثة، ثلاثة، ثلاثة، ثلاثة، ثلاثة، ثلاثة،
+
+121
+00:10:55,320 --> 00:10:56,720
+ثلاثة، ثلاثة، ثلاثة، ثلاثة، ثلاثة، ثلاثة، ثلاثة،
+
+122
+00:10:56,720 --> 00:11:01,320
+ثلاثة، ثلاثة، ثلاثة، ثلاثة، ثلاثة، ثلاثة، ثلاثة،
+
+123
+00:11:01,320 --> 00:11:06,090
+ثلاثة، ثلاثة، ثلاثة، ثلاثة، ثلاثة، ثلاثة، ثلاثة،
+
+124
+00:11:06,090 --> 00:11:11,770
+بتموت في المرحلة الجنينية، لأ، بيعيش، وعلى العكس هو اللي
+
+125
+00:11:11,770 --> 00:11:16,210
+… هو اللي الآن بنحاول نعالجه، وبعدين حكينا بالـ
+
+126
+00:11:16,210 --> 00:11:20,690
+Stem Cell Transplantation، وبنحاول نعطيه Blood
+
+127
+00:11:20,690 --> 00:11:27,810
+Transfusion، نمنع الـ Iron Overload من الـ يعني
+
+128
+00:11:27,810 --> 00:11:33,610
+اللي هو بتلاقي الـ Classical Thalassemia Case
+
+129
+00:11:34,350 --> 00:11:45,130
+بتلاقيه Stunted، يعني في عنده تقزم، يعني اللي هو
+
+130
+00:11:45,130 --> 00:11:51,270
+failure to thrive، أنه بيكون anemic، بيكون عنده
+
+131
+00:11:51,270 --> 00:11:56,090
+hepatosplenomegaly، بيكون عنده hyperpigmentation، بيصير
+
+132
+00:11:56,090 --> 00:11:59,830
+عنده crossing of the bones of the face، بيكون
+
+133
+00:11:59,830 --> 00:12:04,250
+هيك وجهه، كل هذه المظاهر للي عنده ثلاثة deletions
+
+134
+00:12:04,250 --> 00:12:07,550
+واضحة؟
+
+135
+00:12:07,550 --> 00:12:15,250
+في أسئلة ثانية؟
+
+136
+00:12:15,250 --> 00:12:29,250
+اليوم صراحة محاضرة معجبة كتير الفصل يعني هنا
+
+137
+00:12:29,250 --> 00:12:35,960
+بتتكلم على الأنواع المختلفة من الـ Genetic Diseases
+
+138
+00:12:35,960 --> 00:12:42,000
+غير الـ Hemoglobinopathy، غير الـ Hemoglobin
+
+139
+00:12:42,000 --> 00:12:47,140
+Anomalies، فبالنسبة
+
+140
+00:12:47,140 --> 00:12:56,160
+للـ Spectrum أو الـ Range أو المدى من الـ
+
+141
+00:12:56,160 --> 00:13:00,080
+Conditions اللي بدأوا يتكلموا عنها
+
+142
+00:13:03,300 --> 00:13:06,080
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+143
+00:13:06,080 --> 0:13:07,240
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+144
+00:13:07,240 --> 00:13:13,100
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+145
+00:13:13,100 --> 00:13:13,480
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+146
+00:13:13,480 --> 00:13:15,480
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+147
+00:13:15,480 --> 00:13:17,800
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+148
+00:13:17,800 --> 00:13:18,320
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+149
+00:13:18,320 --> 00:13:20,900
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+150
+00:13:20,900 --> 00:13:22,580
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+151
+00:13:29,290 --> 00:13:36,710
+بطريقة ما، يحاول يجمع هذه المعلومات ويكون مذكرة
+
+152
+00:13:36,710 --> 00:13:49,630
+الـ Diseases اللي راح نغطيها بالنسبة للمحاضرة هذه
+
+153
+00:13:49,630 --> 00:13:56,970
+مقسمينها عندكم في الكتاب على أساس الـ Cellular
+
+154
+00:13:56,970 --> 00:14:01,850
+Localization، وين الخلل
+
+155
+00:14:01,850 --> 00:14:10,250
+في أي مكان، فإذا بناخدهم بالترتيب
+
+156
+00:14:10,250 --> 00:14:17,050
+بهذا الشكل، الـ first type of diseases are diseases
+
+157
+00:14:17,050 --> 00:14:22,530
+which are in organelles، فيه الـ mitochondrial
+
+158
+00:14:22,530 --> 00:14:29,440
+diseases، أنا بفضل إنه لو هيك نركز على نوع من الـ من
+
+159
+00:14:29,440 --> 00:14:36,380
+الـ Diseases، على الأقل، على أساس نتذكر إنه عبارة
+
+160
+00:14:36,380 --> 00:14:45,660
+عن يعني مثال لمجموعة مثل هذه، فالـ Mitochondrial
+
+161
+00:14:45,660 --> 00:14:51,250
+Diseases، هنا بالـ Oxidative Phosphorylation، في الـ
+
+162
+00:14:51,250 --> 00:14:55,930
+Leber Hereditary Optic Neuropathy، وحكينا الـ
+
+163
+00:14:55,930 --> 00:15:02,570
+«ميتوكندريال» DNA Disease، يعني الميتوكندريا فرن
+
+164
+00:15:02,570 --> 00:15:09,750
+الطاقة في الخلية، ومصدر الـ ATP اللي بتستخدمه في كل
+
+165
+00:15:09,750 --> 00:15:15,870
+التفاعلات والأنشطة اللي بتقوم فيها الخلية، غالبية
+
+166
+00:15:15,870 --> 00:15:23,150
+البروتينات فيها من الـ «ميتوكندريال» DNA أو الـ
+
+167
+00:15:23,150 --> 00:15:29,050
+Mitochondrial chromosome، وبالتالي، يعني بنورث
+
+168
+00:15:29,050 --> 00:15:34,730
+بطريقة معينة، عن طريق الأم فقط، بينما في الـ
+
+169
+00:15:34,730 --> 00:15:39,810
+Mitochondria itself، some other proteins and things
+
+170
+00:15:39,810 --> 00:15:45,770
+needed، بتكون  حتى بالـ Nuclear DNA، يعني أحياناً
+
+171
+00:15:45,770 --> 00:15:50,530
+الـ Mitochondria نفسها فيها DNA، فيها chromosome
+
+172
+00:15:51,680 --> 00:15:56,500
+نحتاجه، يستخدم، يستفاد منه، أو يعني يستخدم ومهم
+
+173
+00:15:56,500 --> 00:15:59,760
+لنفس الـ Mitochondria، في الغالب، بس الـ
+
+174
+00:15:59,760 --> 00:16:04,980
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/nm86yn-CITA_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/nm86yn-CITA_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..9b1c27d97c5d4667a7c7a2476d24385dbcbde56e
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/nm86yn-CITA_postprocess.srt
@@ -0,0 +1,788 @@
+1
+00:00:00,000 --> 00:00:08,840
+بالنسبة لـ «عشان نربط الأمور ببعض» أتأمل الجدول
+
+2
+00:00:08,840 --> 00:00:15,240
+هذا يكون موجود، شايفينه يعني
+
+3
+00:00:15,240 --> 00:00:18,540
+كمرض،
+
+4
+00:00:18,540 --> 00:00:22,340
+وكنوع
+
+5
+00:00:22,340 --> 00:00:26,600
+من الأمراض الوراثية الـsickle cell والثلاثيميا،
+
+6
+00:00:26,600 --> 00:00:30,760
+أنيميا البحر الأبيض المتوسطالأنيمية المنجلية
+
+7
+00:00:30,760 --> 00:00:36,540
+كأمراض دم من المواضيع اللي يعني مفهومة بشكل كبير
+
+8
+00:00:36,540 --> 00:00:43,340
+وفيه جوانب معروفة كثير وحالة شائعة بسبب أدى الظروف
+
+9
+00:00:43,340 --> 00:00:49,200
+الاشي اللي كان ناقص من الجداول والـFigures اللي
+
+10
+00:00:49,200 --> 00:00:53,560
+حطيناها الأسبوع المحاضرة اللي فاتت اللي هو الجدول
+
+11
+00:00:53,560 --> 00:00:55,120
+هذا وابعتبره كمان مهم
+
+12
+00:00:57,850 --> 00:01:04,490
+اتفقنا على أنه بالنسبة للـ «هيموغلوبين» فيه عنا
+
+13
+00:01:04,490 --> 00:01:12,970
+أربع فيه عنا أربع copies
+
+14
+00:01:12,970 --> 00:01:16,630
+of the Alpha gene وفيه عنا two copies of the Beta
+
+15
+00:01:16,630 --> 00:01:24,970
+chain gene وبالنسبة للـ «ألفا»
+
+16
+00:01:24,970 --> 00:01:31,710
+في الغالبوبكون هو اللي بيعطينا ثلاثيميا وبتكون عن
+
+17
+00:01:31,710 --> 00:01:36,710
+طريق الـ deletions الـ Beta-thalassemia ممكنة برضه
+
+18
+00:01:36,710 --> 00:01:40,630
+بس الأكثر بالنسبة للـ Beta-chain أنه يكون أنها
+
+19
+00:01:40,630 --> 00:01:46,310
+qualitative hemoglobinopathies زي السكل والـ other
+
+20
+00:01:46,310 --> 00:01:51,590
+types of hemoglobin وحكينا عن الـ genetics تبعتهم
+
+21
+00:01:52,340 --> 00:01:59,340
+بحب أذكر بإيه اللي هو بالنسبة
+
+22
+00:01:59,340 --> 00:02:05,380
+للـ «الفا ثلاثيمية» بالنسبة لإنه عندنا أربعة
+
+23
+00:02:05,380 --> 00:02:09,780
+copies of the Alpha genes two copies in each
+
+24
+00:02:09,780 --> 00:02:14,280
+chromosome فعندي أربعة، لما يكون عندي الأربعة
+
+25
+00:02:14,280 --> 00:02:20,040
+بيكون عندي functional طبعاً Alpha Alpha Alpha
+
+26
+00:02:20,040 --> 00:02:24,890
+Alpha بيكونإن الـ Alpha Chain Production 100% من
+
+27
+00:02:24,890 --> 00:02:30,950
+القيمة لما يكون عندي ثلاث مقاطع بيكون عندي Silent
+
+28
+00:02:30,950 --> 00:02:37,230
+Career يعني غير أنه Career، يعني Silent، يعني It
+
+29
+00:02:37,230 --> 00:02:43,530
+looks normal فبالنسبة إن الـ
+
+30
+00:02:43,530 --> 00:02:50,060
+Alpha Chain Production حوالي 75%ويكون عندي ثلاث
+
+31
+00:02:50,060 --> 00:02:55,320
+مقاطع تمشي أكثر على إنه في عندي deletions دليشنز
+
+32
+00:02:55,320 --> 00:03:02,560
+بمعنى جين عكس
+
+33
+00:03:02,560 --> 00:03:08,040
+مثلا الـ Sickle cell جين بيشتغل ويطلع طلبة بتاع
+
+34
+00:03:08,040 --> 00:03:13,480
+الـ Chain بس Abnormal هنا لأ، بيكون معناته بس إنه
+
+35
+00:03:13,480 --> 00:03:17,540
+كمية الـ Hemoglobin اللي بتطلع أو الـ Alpha Chain
+
+36
+00:03:17,960 --> 00:03:23,340
+في الحالة هذه بتكون الـ Decrease لما يكون عندى Two
+
+37
+00:03:23,340 --> 00:03:27,600
+copies deleted
+
+38
+00:03:27,600 --> 00:03:30,820
+لما يكون عندى Two copies بيكون الـ Alpha
+
+39
+00:03:30,820 --> 00:03:36,060
+-thalassemia trait هذا اللي شائع وبتلاقي بعطينا
+
+40
+00:03:36,060 --> 00:03:41,340
+شوية لـ Mild Anemia وMicrocytosis الـ RDW Red Cell
+
+41
+00:03:41,340 --> 00:03:44,860
+Distribution اللي بيكون Normal وبكون عندى Two
+
+42
+00:03:44,860 --> 00:03:49,150
+copies بس اللي شغلت بهذه الطريقةواحدة على كل
+
+43
+00:03:49,150 --> 00:03:52,590
+كرموزوم أو واحدة على كرموزوم طبيعي تمامًا أو
+
+44
+00:03:52,590 --> 00:04:01,650
+اتخذتان على اخر كرموزوم وكون 50% من المشكلة موجودة
+
+45
+00:04:01,650 --> 00:04:08,970
+في إذا عندنا ثلاث مقاطع أخرجتبيصير عندي ما هو الـ
+
+46
+00:04:08,970 --> 00:04:13,150
+«تلاثيميا» الـ Disease «تلاثيميا» الـ «تلاثيميا»
+
+47
+00:04:13,150 --> 00:04:13,170
+الـ «تلاثيميا» الـ «تلاثيميا» الـ «تلاثيميا» الـ
+
+48
+00:04:13,170 --> 00:04:13,250
+«تلاثيميا» الـ «تلاثيميا» الـ «تلاثيميا» الـ
+
+49
+00:04:13,250 --> 00:04:13,350
+«تلاثيميا» الـ «تلاثيميا» الـ «تلاثيميا» الـ
+
+50
+00:04:13,350 --> 00:04:13,470
+«تلاثيميا» الـ «تلاثيميا» الـ «تلاثيميا» الـ
+
+51
+00:04:13,470 --> 00:04:25,070
+«تلاثيميا» الـ «تلاثيميا» الـ «تلاثيميا»
+
+52
+00:04:25,070 --> 00:04:34,010
+الـ «تلاثيميا» الـ «تلاثيميا»
+
+53
+00:04:34,010 --> 00:04:37,980
+الـ «تلاثيميا» الـ «تلإذا عندي أربعة copies
+
+54
+00:04:37,980 --> 00:04:43,360
+removed بيسموه الـ Hemoglobin Parts أو High Drops
+
+55
+00:04:43,360 --> 00:04:47,300
+in Talis أو Homozygous Alpha Thalassemia بيكون
+
+56
+00:04:47,300 --> 00:04:54,240
+Very Severe، الجنين ما بيقاشش فبتأمل
+
+57
+00:04:54,240 --> 00:05:00,540
+أنه يكون هي قطينا الحالات
+
+58
+00:05:00,540 --> 00:05:01,680
+اللي بيكون فيها
+
+59
+00:05:04,260 --> 00:05:12,460
+وهي أول مجموعة من الأمراض الوراثية اللي راح نبطيهم
+
+60
+00:05:12,460 --> 00:05:18,720
+في أسئلة في
+
+61
+00:05:18,720 --> 00:05:21,240
+أسئلة للمرحلة الحالية
+
+62
+00:05:32,280 --> 00:05:47,740
+الآن بالنسبة لـ «دكتور» من «كريم»، ها تفضّل «كريم»
+
+63
+00:05:47,740 --> 00:05:52,100
+إن شاء الله تكون تبعت موضوع
+
+64
+00:05:53,700 --> 00:05:58,680
+لما حطينا الـ «A» والـ «B» والـ «O» هيموجلوبيات
+
+65
+00:05:58,680 --> 00:06:04,960
+كيف حسبناها حسبناها يعني أسهل طريقة أن نطلعها
+
+66
+00:06:04,960 --> 00:06:14,730
+للأسف الأرقام اللي حطيتها كانت يعني أرقامشو اسمه؟
+
+67
+00:06:14,730 --> 00:06:22,990
+يعني خطأ بس الفكرة إن الـ «O» بتطلع منها يعني الـ
+
+68
+00:06:22,990 --> 00:06:28,670
+«O incidence» بتطلع منها تأخذ الجدر تبعها تعطينا
+
+69
+00:06:28,670 --> 00:06:37,690
+الـ «frequency» تبعت الـ «O» الـ «O» group والبقية
+
+70
+00:06:37,690 --> 00:06:39,790
+بيكونوا الـ «O»
+
+71
+00:06:44,380 --> 00:06:50,140
+عشان الـ «أو» بتدوش كله قليل متنحي فطلعته لحاله
+
+72
+00:06:50,140 --> 00:06:51,640
+«أو» بيطلع لحاله «أو» بيطلع لحاله «أو» بيطلع لحاله
+
+73
+00:06:51,640 --> 00:06:55,960
+«أو» بيطلع لحاله «أو»
+
+74
+00:06:55,960 --> 00:06:56,280
+بيطلع لحاله «أو» بيطلع لحاله «أو» بيطلع لحاله «أو»
+
+75
+00:06:56,280 --> 00:06:56,540
+بيطلع لحاله «أو» بيطلع لحاله «أو» بيطلع لحاله «أو»
+
+76
+00:06:56,540 --> 00:07:00,420
+بيطلع لحاله «أو» بيطلع لحاله «أو» بيطلع لحاله «أو»
+
+77
+00:07:00,420 --> 00:07:08,380
+بيطلع لحاله «أو» بيطلع
+
+78
+00:07:08,380 --> 00:07:14,350
+لحتعطينا الـ «A» والـ «B» frequency أثنانهم مع بعض
+
+79
+00:07:14,350 --> 00:07:20,170
+ولمّا يكون الواحد عنده «A» «B» blood group، معناته
+
+80
+00:07:20,170 --> 00:07:33,070
+إثنين شغلات فعندك معادلتين، يعني عندك أنه الـ «A»
+
+81
+00:07:33,070 --> 00:07:35,410
+ترمية، ضمن «B» ترمية يستخدم الـ «A» يستخدم الـ «B»
+
+82
+00:07:35,410 --> 00:07:35,690
+يستخدم الـ «A» يستخدم الـ «B» يستخدم الـ «A»
+
+83
+00:07:35,690 --> 00:07:37,410
+يستخدم الـ «B» يستخدم الـ «A» يستخدم الـ «B»
+
+84
+00:07:37,410 --> 00:07:37,490
+يستخدم الـ «A» يستخدم الـ «B» يستخدم الـ «A»
+
+85
+00:07:37,490 --> 00:07:41,690
+يستخدم الـ «Aوإيه إذا كان واحد ماجس الـ «Control»
+
+86
+00:07:41,690 --> 00:07:51,230
+فبقى الـ «B»؟ أه، فعندك معدلتين يعني الـ «AB Rate»
+
+87
+00:07:51,230 --> 00:07:55,950
+هو يمثل الـ frequency تبع الأليل تبع الـ «A» في
+
+88
+00:07:55,950 --> 00:07:59,510
+الـ frequency تبع الأليل تبع الـ «B» لأن هذا حصل
+
+89
+00:07:59,510 --> 00:08:08,350
+ضربهم، فمعناك كيف؟ فزائد أنهواحد ناقص الـ
+
+90
+00:08:08,350 --> 00:08:14,310
+Frequency تبع الـ O تعطينا رقم يمثل الـ Frequency
+
+91
+00:08:14,310 --> 00:08:18,290
+تبع الـ A زاد الـ Frequency تبع الـ B فعندك
+
+92
+00:08:18,290 --> 00:08:22,710
+معادلتين بمجهولين بتحلهم، بتطلع لك شو النتيجة،
+
+93
+00:08:22,710 --> 00:08:29,030
+فمعناك يا؟ أه، شو السؤال الثاني يا كريم؟اللي بيكون
+
+94
+00:08:29,030 --> 00:08:33,050
+عنده نقص في أربع سلاسل ألفة في الحالات اللي جابله،
+
+95
+00:08:33,050 --> 00:08:37,230
+بيتوفى في مرحلة الجنين و لا بيبقى عايش؟ ‏-اللي هو
+
+96
+00:08:37,230 --> 00:08:41,730
+الـHydrops Fetalis ‏-في الجنون، كده بتقول شوية،
+
+97
+00:08:41,730 --> 00:08:46,790
+صحيح ‏-الـHydrops Fetalis، أربع deletions very
+
+98
+00:08:46,790 --> 00:08:51,970
+severe نيوناتالي، يعني مش نيوناتالي، in vitro they
+
+99
+00:08:51,970 --> 00:08:57,650
+will die، يعني بيصير و هو بطن أمهالـ High Drops
+
+100
+00:08:57,650 --> 00:09:03,950
+Fetalis هي حالة بيصير يعني زي أنيميا شديدة في
+
+101
+00:09:03,950 --> 00:09:11,570
+الجنين فبالتالي بيعشش، شايف علي؟ بالنسبة للـ High
+
+102
+00:09:11,570 --> 00:09:17,650
+Drops Fetalis السبب الثاني اللي هو الـ Rh
+
+103
+00:09:17,650 --> 00:09:18,930
+Incompatibility
+
+104
+00:09:20,700 --> 00:09:24,900
+لما يصير أنه بعد الأول جنين وثاني جنين إذا ما
+
+105
+00:09:24,900 --> 00:09:30,360
+اتدخلوا لطباء وصار الـ Rh-incompatibility راح يصير
+
+106
+00:09:30,360 --> 00:09:36,880
+أنه بعد هيك كل ما تحمل يموت الجنين لسبب أنه فيه
+
+107
+00:09:36,880 --> 00:09:42,300
+antibodies تدخل تكسر الـ Red blood cells وبالتالي
+
+108
+00:09:42,300 --> 00:09:49,220
+تخلي الجنين يموتفالـ «هيدروبس» في «تاليس» فيه
+
+109
+00:09:49,220 --> 00:09:55,120
+مثلًا الـ «ثالثيميا» يعني Alpha-thalassemia major
+
+110
+00:09:55,120 --> 00:10:01,720
+اللي هي four deletions أو الـ parts، hemoglobin
+
+111
+00:10:01,720 --> 00:10:07,720
+parts أو ما هو اسمه؟ اللي هو مثلًا الـimmune
+
+112
+00:10:07,720 --> 00:10:09,120
+hemolytic anemia
+
+113
+00:10:11,460 --> 00:10:19,780
+الـ Rh-incompatibility إذا ما تعالجت بالشكل الصحيح
+
+114
+00:10:19,780 --> 00:10:24,320
+هدول الحالتين بيعملوا إيش يبقوا نقوله «high-drops
+
+115
+00:10:24,320 --> 00:10:32,520
+fetalis» «سيفير آيرون» أو «سيفير أنيميا» في الوقت
+
+116
+00:10:32,520 --> 00:10:37,280
+الـ «فيتال» ويكونوا مرتبطين بالحياة
+
+117
+00:10:40,920 --> 00:10:45,780
+في سؤال؟ يعني حتى التلاتة برضه ممكن يكون مميز في
+
+118
+00:10:45,780 --> 00:10:50,700
+الجانب أيش هو؟ حتى لو كان عنده نقص تلاتة، تلاتة،
+
+119
+00:10:50,700 --> 00:10:53,880
+تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتة،
+
+120
+00:10:53,880 --> 00:10:55,320
+تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتة،
+
+121
+00:10:55,320 --> 00:10:56,720
+تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتة،
+
+122
+00:10:56,720 --> 00:11:01,320
+تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتة،
+
+123
+00:11:01,320 --> 00:11:06,090
+تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتبموت
+
+124
+00:11:06,090 --> 00:11:11,770
+في المرحلة الجنينية، لأ، بيعيش وعلى العكس هو اللي
+
+125
+00:11:11,770 --> 00:11:16,210
+… هو اللي الآن بنحاول نعالجه وبعدين حكينا بالـ
+
+126
+00:11:16,210 --> 00:11:20,690
+Stem Cell Transplantation وبنحاول نعطيه Blood
+
+127
+00:11:20,690 --> 00:11:27,810
+Translucent نمنع الـ Iron Overload من الـ يعني
+
+128
+00:11:27,810 --> 00:11:33,610
+اللي هو بتلاقي الـ Classical Thalassemia Case
+
+129
+00:11:34,350 --> 00:11:45,130
+بتلاقيه Stunted يعني في عنده تقزم يعني اللي هو
+
+130
+00:11:45,130 --> 00:11:51,270
+failure to thrive أنه بيكون anemic بيكون عنده
+
+131
+00:11:51,270 --> 00:11:56,090
+hepatosplenomy بيكون عنده hyperpigmentation بيصير
+
+132
+00:11:56,090 --> 00:11:59,830
+عنده crossing of the bones of the face بيكون
+
+133
+00:11:59,830 --> 00:12:04,250
+هيكوجه كل هذه المظاهر للي عندهثلاثة deletions
+
+134
+00:12:04,250 --> 00:12:07,550
+واضحة؟
+
+135
+00:12:07,550 --> 00:12:15,250
+في أسئلة ثانية؟
+
+136
+00:12:15,250 --> 00:12:29,250
+اليوم صراحة محاضرة معجوبة كثير الفصل يعني هنا
+
+137
+00:12:29,250 --> 00:12:35,960
+بتتكلم على الأنواع المختلفةمن الـ Genetic Diseases
+
+138
+00:12:35,960 --> 00:12:42,000
+غير الـ Hemoglobinopathy غير الـ Hemoglobin
+
+139
+00:12:42,000 --> 00:12:47,140
+Anomalies فبالنسبة
+
+140
+00:12:47,140 --> 00:12:56,160
+للـ Spectrum أو الـ Range أو المدى من الـ
+
+141
+00:12:56,160 --> 00:13:00,080
+Conditions اللي بدوا يتكلموا عنها
+
+142
+00:13:03,300 --> 00:13:06,080
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+143
+00:13:06,080 --> 00:13:07,240
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+144
+00:13:07,240 --> 00:13:13,100
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+145
+00:13:13,100 --> 00:13:13,480
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+146
+00:13:13,480 --> 00:13:15,480
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+147
+00:13:15,480 --> 00:13:17,800
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+148
+00:13:17,800 --> 00:13:18,320
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+149
+00:13:18,320 --> 00:13:20,900
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+150
+00:13:20,900 --> 00:13:22,580
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+151
+00:13:29,290 --> 00:13:36,710
+بطريقة ما يحاول يجمع هذه المعلومات ويكون منذكرها
+
+152
+00:13:36,710 --> 00:13:49,630
+الـ Diseases اللي راح نغطيها بالنسبة للمحاضرة هذه
+
+153
+00:13:49,630 --> 00:13:56,970
+مقسمينها عندكم في الكتاب على أساسالـ Cellular
+
+154
+00:13:56,970 --> 00:14:01,850
+Localization وين الخلل
+
+155
+00:14:01,850 --> 00:14:10,250
+في أي مكان فإذا بناخدهم بالترتيب
+
+156
+00:14:10,250 --> 00:14:17,050
+بهذا الشكل الـ first type of diseases are diseases
+
+157
+00:14:17,050 --> 00:14:22,530
+which are in organelles ففيه الـ mitochondrial
+
+158
+00:14:22,530 --> 00:14:29,440
+diseasesأنا بفضل إنه لو هيك نركز على نوع من الـ من
+
+159
+00:14:29,440 --> 00:14:36,380
+الـ Diseases على الأقل، على أساس نتذكر إنه عبارة
+
+160
+00:14:36,380 --> 00:14:45,660
+عن يعني مثال لمرحلة مثل هذه فالـ Mitochondrial
+
+161
+00:14:45,660 --> 00:14:51,250
+Diseases هنا بالـ Oxidative Phosphorylationفي الـ
+
+162
+00:14:51,250 --> 00:14:55,930
+Bayer Hereditary Optical Neuropathy وحكينا الـ
+
+163
+00:14:55,930 --> 00:15:02,570
+«ميتوكندريال» DNA Disease يعني الميتوكندريال فرن
+
+164
+00:15:02,570 --> 00:15:09,750
+الطاقة في الخلية ومصدر الـ ATP اللي بتستخدمه في كل
+
+165
+00:15:09,750 --> 00:15:15,870
+التفاعلات والأنشطة اللي بتقوم فيها الخلية غالبية
+
+166
+00:15:15,870 --> 00:15:23,150
+البروتينات فيها من الـ «ميتوكندريال»الـ DNA أو الـ
+
+167
+00:15:23,150 --> 00:15:29,050
+Mitochondrial chromosome وبالتالي، يعني بننتقل
+
+168
+00:15:29,050 --> 00:15:34,730
+بطريقة معينة عن طريق الأم فقط بينما في الـ
+
+169
+00:15:34,730 --> 00:15:39,810
+Mitochondria itself some other proteins and things
+
+170
+00:15:39,810 --> 00:15:45,770
+needed بتكون لأ حتى بالـ Nuclear DNA يعني أحيانًا
+
+171
+00:15:45,770 --> 00:15:50,530
+الـ Mitochondria نفسها فيها DNA، فيها chromosome
+
+172
+00:15:51,680 --> 00:15:56,500
+نحتاجه، يستخدم، يستفاد منه أو يعني يستخدم ومهم
+
+173
+00:15:56,500 --> 00:15:59,760
+لنفس الـ Mitochondria في الغالب، بس الـ
+
+174
+00:15:59,760 --> 00:16:04,980
+Mitochondria نفسها في بعض الأشياء اللي بتكون يعني
+
+175
+00:16:04,980 --> 00:16:13,000
+كرومزوما في الـ Nuclear DNA Translation of
+
+176
+00:16:13,000 --> 00:16:24,060
+Mitochondrial Diseases يعني فينفس الـ «ميوتاشن» في
+
+177
+00:16:24,060 --> 00:16:29,840
+نفس الـ «ميتوكندريال» الـ «DNA» وفيه، لأ الـ
+
+178
+00:16:29,840 --> 00:16:40,660
+«ميتوكندريال» الـ «DNA» مش كتير خربان ولكن فيه الـ
+
+179
+00:16:40,660 --> 00:16:47,650
+Further steps يكون فيها مشكلةفبتصير في الـ
+
+180
+00:16:47,650 --> 00:16:51,410
+Translation of Mitochondrial Diseases زي مثلًا الـ
+
+181
+00:16:51,410 --> 00:16:59,630
+Sensory Neuronal Deafness الإشي اللي بيسموه حاولت
+
+182
+00:16:59,630 --> 00:17:07,310
+أدور عليها Melas Strokes وLactic Acidosis
+
+183
+00:17:07,310 --> 00:17:13,210
+وMeningoencephalitis يعني إصابة دماغية الكهاب
+
+184
+00:17:13,210 --> 00:17:19,830
+الدماغ والسحايةزائد Lactic Acidosis متابولك
+
+185
+00:17:19,830 --> 00:17:26,310
+أسدوسيز بتكون حالة وهي بتكون شديدة وزائد
+
+186
+00:17:26,310 --> 00:17:29,910
+Picture of a Stroke اللي هي جلطة على الدماغ يعني
+
+187
+00:17:29,910 --> 00:17:36,290
+فهذه الحالة بتكون أحيانًا نتيجة خلل في الـ
+
+188
+00:17:36,290 --> 00:17:40,040
+Translation of the mitochondrial diseasesفيه إيش
+
+189
+00:17:40,040 --> 00:17:45,680
+اسمه الـ Paroxysomes زي إيش اسمه الـ Zolliger
+
+190
+00:17:45,680 --> 00:17:50,620
+Syndrome بالأول فكرتها Zolliger Syndrome الـ
+
+191
+00:17:50,620 --> 00:17:54,320
+Zolliger اللي بنون هذا الـ disease بيكون
+
+192
+00:17:54,320 --> 00:18:02,980
+Hypersecretion of Gastrin ويصير عندي زي Gastrinoma
+
+193
+00:18:02,980 --> 00:18:11,190
+ويكونأو كده وكده، لا، هيزوليجر عبارة عن الـ
+
+194
+00:18:11,190 --> 00:18:15,610
+neurological condition فيه الـ lysosomal disease
+
+195
+00:18:15,610 --> 00:18:20,930
+نتيجة الخلل في الـ lysosomal enzymes الـ lysosomal
+
+196
+00:18:20,930 --> 00:18:27,230
+enzymes عبارة عن الليسوزوم هو يعني بالذات للـ
+
+197
+00:18:27,230 --> 00:18:30,110
+phagocytes في المناعة عبارة عن
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/nm86yn-CITA_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/nm86yn-CITA_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..16c1f6fbcfb3800fefd96f9ab3148cb5f27b81bf
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/nm86yn-CITA_raw.srt
@@ -0,0 +1,796 @@
+1
+00:00:00,000 --> 00:00:08,840
+بالنسبة لـ «عشان نربط الأمور ببعض» أتأمل الجدول
+
+2
+00:00:08,840 --> 00:00:15,240
+هذا يكون موجود، شايفينه يعني
+
+3
+00:00:15,240 --> 00:00:18,540
+كمرض،
+
+4
+00:00:18,540 --> 00:00:22,340
+وكنوع
+
+5
+00:00:22,340 --> 00:00:26,600
+من الأمراض الوراثية الـsickle cell والثلاثيميا،
+
+6
+00:00:26,600 --> 00:00:30,760
+أنيميا البحر الأبيض المتوسطالأنيمية المنجلية
+
+7
+00:00:30,760 --> 00:00:36,540
+كأمراض دم من المواضيع اللي يعني مفهومة بشكل كبير
+
+8
+00:00:36,540 --> 00:00:43,340
+وفيه جوانب معروفة كثير وحالة شائعة بسبب أدى الظروف
+
+9
+00:00:43,340 --> 00:00:49,200
+الاشي اللي كان ناقص من الجداول والـFigures اللي
+
+10
+00:00:49,200 --> 00:00:53,560
+حطيناها الأسبوع المحاضرة اللي فاتت اللي هو الجدول
+
+11
+00:00:53,560 --> 00:00:55,120
+هذا وابعتبره كمان مهم
+
+12
+00:00:57,850 --> 00:01:04,490
+اتفقنا على أنه بالنسبة للـ «هيموغلوبين» فيه عنا
+
+13
+00:01:04,490 --> 00:01:12,970
+أربع فيه عنا أربع copies
+
+14
+00:01:12,970 --> 00:01:16,630
+of the Alpha gene وفيه عنا two copies of the Beta
+
+15
+00:01:16,630 --> 00:01:24,970
+chain gene وبالنسبة للـ «ألفا»
+
+16
+00:01:24,970 --> 00:01:31,710
+في الغالبوبكون هو اللي بيعطينا ثلاثيميا وبتكون عن
+
+17
+00:01:31,710 --> 00:01:36,710
+طريق الـ deletions الـ Beta-thalassemia ممكنة برضه
+
+18
+00:01:36,710 --> 00:01:40,630
+بس الأكثر بالنسبة للـ Beta-chain أنه يكون أنها
+
+19
+00:01:40,630 --> 00:01:46,310
+qualitative hemoglobinopathies زي السكل والـ other
+
+20
+00:01:46,310 --> 00:01:51,590
+types of hemoglobin وحكينا عن الـ genetics تبعتهم
+
+21
+00:01:52,340 --> 00:01:59,340
+بحب أذكر بإيه اللي هو بالنسبة
+
+22
+00:01:59,340 --> 00:02:05,380
+للـ «الفا ثلاثيمية» بالنسبة لإنه عندنا أربعة
+
+23
+00:02:05,380 --> 00:02:09,780
+copies of the Alpha genes two copies in each
+
+24
+00:02:09,780 --> 00:02:14,280
+chromosome فعندي أربعة، لما يكون عندي الأربعة
+
+25
+00:02:14,280 --> 00:02:20,040
+بيكون عندي functional طبعاً Alpha Alpha Alpha
+
+26
+00:02:20,040 --> 00:02:24,890
+Alpha بيكونإن الـ Alpha Chain Production 100% من
+
+27
+00:02:24,890 --> 00:02:30,950
+القيمة لما يكون عندي ثلاث مقاطع بيكون عندي Silent
+
+28
+00:02:30,950 --> 00:02:37,230
+Career يعني غير أنه Career، يعني Silent، يعني It
+
+29
+00:02:37,230 --> 00:02:43,530
+looks normal فبالنسبة إن الـ
+
+30
+00:02:43,530 --> 00:02:50,060
+Alpha Chain Production حوالي 75%ويكون عندي ثلاث
+
+31
+00:02:50,060 --> 00:02:55,320
+مقاطع تمشي أكثر على إنه في عندي deletions دليشنز
+
+32
+00:02:55,320 --> 00:03:02,560
+بمعنى جين عكس
+
+33
+00:03:02,560 --> 00:03:08,040
+مثلا الـ Sickle cell جين بيشتغل ويطلع طلبة بتاع
+
+34
+00:03:08,040 --> 00:03:13,480
+الـ Chain بس Abnormal هنا لأ، بيكون معناته بس إنه
+
+35
+00:03:13,480 --> 00:03:17,540
+كمية الـ Hemoglobin اللي بتطلع أو الـ Alpha Chain
+
+36
+00:03:17,960 --> 00:03:23,340
+في الحالة هذه بتكون الـ Decrease لما يكون عندى Two
+
+37
+00:03:23,340 --> 00:03:27,600
+copies deleted
+
+38
+00:03:27,600 --> 00:03:30,820
+لما يكون عندى Two copies بيكون الـ Alpha
+
+39
+00:03:30,820 --> 00:03:36,060
+-thalassemia trait هذا اللي شائع وبتلاقي بعطينا
+
+40
+00:03:36,060 --> 00:03:41,340
+شوية لـ Mild Anemia وMicrocytosis الـ RDW Red Cell
+
+41
+00:03:41,340 --> 00:03:44,860
+Distribution اللي بيكون Normal وبكون عندى Two
+
+42
+00:03:44,860 --> 00:03:49,150
+copies بس اللي شغلت بهذه الطريقةواحدة على كل
+
+43
+00:03:49,150 --> 00:03:52,590
+كرموزوم أو واحدة على كرموزوم طبيعي تمامًا أو
+
+44
+00:03:52,590 --> 00:04:01,650
+اتخذتان على اخر كرموزوم وكون 50% من المشكلة موجودة
+
+45
+00:04:01,650 --> 00:04:08,970
+في إذا عندنا ثلاث مقاطع أخرجتبيصير عندي ما هو الـ
+
+46
+00:04:08,970 --> 00:04:13,150
+«تلاثيميا» الـ Disease «تلاثيميا» الـ «تلاثيميا»
+
+47
+00:04:13,150 --> 00:04:13,170
+الـ «تلاثيميا» الـ «تلاثيميا» الـ «تلاثيميا» الـ
+
+48
+00:04:13,170 --> 00:04:13,250
+«تلاثيميا» الـ «تلاثيميا» الـ «تلاثيميا» الـ
+
+49
+00:04:13,250 --> 00:04:13,350
+«تلاثيميا» الـ «تلاثيميا» الـ «تلاثيميا» الـ
+
+50
+00:04:13,350 --> 00:04:13,470
+«تلاثيميا» الـ «تلاثيميا» الـ «تلاثيميا» الـ
+
+51
+00:04:13,470 --> 00:04:25,070
+«تلاثيميا» الـ «تلاثيميا» الـ «تلاثيميا»
+
+52
+00:04:25,070 --> 00:04:34,010
+الـ «تلاثيميا» الـ «تلاثيميا»
+
+53
+00:04:34,010 --> 00:04:37,980
+الـ «تلاثيميا» الـ «تلإذا عندي أربعة copies
+
+54
+00:04:37,980 --> 00:04:43,360
+removed بيسموه الـ Hemoglobin Parts أو High Drops
+
+55
+00:04:43,360 --> 00:04:47,300
+in Talis أو Homozygous Alpha Thalassemia بيكون
+
+56
+00:04:47,300 --> 00:04:54,240
+Very Severe، الجنين ما بيقاشش فبتأمل
+
+57
+00:04:54,240 --> 00:05:00,540
+أنه يكون هي قطينا الحالات
+
+58
+00:05:00,540 --> 00:05:01,680
+اللي بيكون فيها
+
+59
+00:05:04,260 --> 00:05:12,460
+وهي أول مجموعة من الأمراض الوراثية اللي راح نبطيهم
+
+60
+00:05:12,460 --> 00:05:18,720
+في أسئلة في
+
+61
+00:05:18,720 --> 00:05:21,240
+أسئلة للمرحلة الحالية
+
+62
+00:05:32,280 --> 00:05:47,740
+الآن بالنسبة لـ «دكتور» من «كريم»، ها تفضّل «كريم»
+
+63
+00:05:47,740 --> 00:05:52,100
+إن شاء الله تكون تبعت موضوع
+
+64
+00:05:53,700 --> 00:05:58,680
+لما حطينا الـ «A» والـ «B» والـ «O» هيموجلوبيات
+
+65
+00:05:58,680 --> 00:06:04,960
+كيف حسبناها حسبناها يعني أسهل طريقة أن نطلعها
+
+66
+00:06:04,960 --> 00:06:14,730
+للأسف الأرقام اللي حطيتها كانت يعني أرقامشو اسمه؟
+
+67
+00:06:14,730 --> 00:06:22,990
+يعني خطأ بس الفكرة إن الـ «O» بتطلع منها يعني الـ
+
+68
+00:06:22,990 --> 00:06:28,670
+«O incidence» بتطلع منها تأخذ الجدر تبعها تعطينا
+
+69
+00:06:28,670 --> 00:06:37,690
+الـ «frequency» تبعت الـ «O» الـ «O» group والبقية
+
+70
+00:06:37,690 --> 00:06:39,790
+بيكونوا الـ «O»
+
+71
+00:06:44,380 --> 00:06:50,140
+عشان الـ «أو» بتدوش كله قليل متنحي فطلعته لحاله
+
+72
+00:06:50,140 --> 00:06:51,640
+«أو» بيطلع لحاله «أو» بيطلع لحاله «أو» بيطلع لحاله
+
+73
+00:06:51,640 --> 00:06:55,960
+«أو» بيطلع لحاله «أو»
+
+74
+00:06:55,960 --> 00:06:56,280
+بيطلع لحاله «أو» بيطلع لحاله «أو» بيطلع لحاله «أو»
+
+75
+00:06:56,280 --> 00:06:56,540
+بيطلع لحاله «أو» بيطلع لحاله «أو» بيطلع لحاله «أو»
+
+76
+00:06:56,540 --> 00:07:00,420
+بيطلع لحاله «أو» بيطلع لحاله «أو» بيطلع لحاله «أو»
+
+77
+00:07:00,420 --> 00:07:08,380
+بيطلع لحاله «أو» بيطلع
+
+78
+00:07:08,380 --> 00:07:14,350
+لحتعطينا الـ «A» والـ «B» frequency أثنانهم مع بعض
+
+79
+00:07:14,350 --> 00:07:20,170
+ولمّا يكون الواحد عنده «A» «B» blood group، معناته
+
+80
+00:07:20,170 --> 00:07:33,070
+إثنين شغلات فعندك معادلتين، يعني عندك أنه الـ «A»
+
+81
+00:07:33,070 --> 00:07:35,410
+ترمية، ضمن «B» ترمية يستخدم الـ «A» يستخدم الـ «B»
+
+82
+00:07:35,410 --> 00:07:35,690
+يستخدم الـ «A» يستخدم الـ «B» يستخدم الـ «A»
+
+83
+00:07:35,690 --> 00:07:37,410
+يستخدم الـ «B» يستخدم الـ «A» يستخدم الـ «B»
+
+84
+00:07:37,410 --> 00:07:37,490
+يستخدم الـ «A» يستخدم الـ «B» يستخدم الـ «A»
+
+85
+00:07:37,490 --> 00:07:37,490
+يستخدم الـ «B» يستخدم الـ «A» يستخدم الـ «B»
+
+86
+00:07:37,490 --> 00:07:41,690
+يستخدم الـ «Aوإيه إذا كان واحد ماجس الـ «Control»
+
+87
+00:07:41,690 --> 00:07:51,230
+فبقى الـ «B»؟ أه، فعندك معدلتين يعني الـ «AB Rate»
+
+88
+00:07:51,230 --> 00:07:55,950
+هو يمثل الـ frequency تبع الأليل تبع الـ «A» في
+
+89
+00:07:55,950 --> 00:07:59,510
+الـ frequency تبع الأليل تبع الـ «B» لأن هذا حصل
+
+90
+00:07:59,510 --> 00:08:08,350
+ضربهم، فمعناك كيف؟ فزائد أنهواحد ناقص الـ
+
+91
+00:08:08,350 --> 00:08:14,310
+Frequency تبع الـ O تعطينا رقم يمثل الـ Frequency
+
+92
+00:08:14,310 --> 00:08:18,290
+تبع الـ A زاد الـ Frequency تبع الـ B فعندك
+
+93
+00:08:18,290 --> 00:08:22,710
+معادلتين بمجهولين بتحلهم، بتطلع لك شو النتيجة،
+
+94
+00:08:22,710 --> 00:08:29,030
+فمعناك يا؟ أه، شو السؤال الثاني يا كريم؟اللي بيكون
+
+95
+00:08:29,030 --> 00:08:33,050
+عنده نقص في أربع سلاسل ألفة في الحالات اللي جابله،
+
+96
+00:08:33,050 --> 00:08:37,230
+بيتوفى في مرحلة الجنين و لا بيبقى عايش؟ ‏-اللي هو
+
+97
+00:08:37,230 --> 00:08:41,730
+الـHydrops Fetalis ‏-في الجنون، كده بتقول شوية،
+
+98
+00:08:41,730 --> 00:08:46,790
+صحيح ‏-الـHydrops Fetalis، أربع deletions very
+
+99
+00:08:46,790 --> 00:08:51,970
+severe نيوناتالي، يعني مش نيوناتالي، in vitro they
+
+100
+00:08:51,970 --> 00:08:57,650
+will die، يعني بيصير و هو بطن أمهالـ High Drops
+
+101
+00:08:57,650 --> 00:09:03,950
+Fetalis هي حالة بيصير يعني زي أنيميا شديدة في
+
+102
+00:09:03,950 --> 00:09:11,570
+الجنين فبالتالي بيعشش، شايف علي؟ بالنسبة للـ High
+
+103
+00:09:11,570 --> 00:09:17,650
+Drops Fetalis السبب الثاني اللي هو الـ Rh
+
+104
+00:09:17,650 --> 00:09:18,930
+Incompatibility
+
+105
+00:09:20,700 --> 00:09:24,900
+لما يصير أنه بعد الأول جنين وثاني جنين إذا ما
+
+106
+00:09:24,900 --> 00:09:30,360
+اتدخلوا لطباء وصار الـ Rh-incompatibility راح يصير
+
+107
+00:09:30,360 --> 00:09:36,880
+أنه بعد هيك كل ما تحمل يموت الجنين لسبب أنه فيه
+
+108
+00:09:36,880 --> 00:09:42,300
+antibodies تدخل تكسر الـ Red blood cells وبالتالي
+
+109
+00:09:42,300 --> 00:09:49,220
+تخلي الجنين يموتفالـ «هيدروبس» في «تاليس» فيه
+
+110
+00:09:49,220 --> 00:09:55,120
+مثلًا الـ «ثالثيميا» يعني Alpha-thalassemia major
+
+111
+00:09:55,120 --> 00:10:01,720
+اللي هي four deletions أو الـ parts، hemoglobin
+
+112
+00:10:01,720 --> 00:10:07,720
+parts أو ما هو اسمه؟ اللي هو مثلًا الـimmune
+
+113
+00:10:07,720 --> 00:10:09,120
+hemolytic anemia
+
+114
+00:10:11,460 --> 00:10:19,780
+الـ Rh-incompatibility إذا ما تعالجت بالشكل الصحيح
+
+115
+00:10:19,780 --> 00:10:24,320
+هدول الحالتين بيعملوا إيش يبقوا نقوله «high-drops
+
+116
+00:10:24,320 --> 00:10:32,520
+fetalis» «سيفير آيرون» أو «سيفير أنيميا» في الوقت
+
+117
+00:10:32,520 --> 00:10:37,280
+الـ «فيتال» ويكونوا مرتبطين بالحياة
+
+118
+00:10:40,920 --> 00:10:45,780
+في سؤال؟ يعني حتى التلاتة برضه ممكن يكون مميز في
+
+119
+00:10:45,780 --> 00:10:50,700
+الجانب أيش هو؟ حتى لو كان عنده نقص تلاتة، تلاتة،
+
+120
+00:10:50,700 --> 00:10:53,880
+تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتة،
+
+121
+00:10:53,880 --> 00:10:55,320
+تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتة،
+
+122
+00:10:55,320 --> 00:10:56,720
+تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتة،
+
+123
+00:10:56,720 --> 00:11:01,320
+تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتة،
+
+124
+00:11:01,320 --> 00:11:06,090
+تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتة، تلاتبموت
+
+125
+00:11:06,090 --> 00:11:11,770
+في المرحلة الجنينية، لأ، بيعيش وعلى العكس هو اللي
+
+126
+00:11:11,770 --> 00:11:16,210
+… هو اللي الآن بنحاول نعالجه وبعدين حكينا بالـ
+
+127
+00:11:16,210 --> 00:11:20,690
+Stem Cell Transplantation وبنحاول نعطيه Blood
+
+128
+00:11:20,690 --> 00:11:27,810
+Translucent نمنع الـ Iron Overload من الـ يعني
+
+129
+00:11:27,810 --> 00:11:33,610
+اللي هو بتلاقي الـ Classical Thalassemia Case
+
+130
+00:11:34,350 --> 00:11:45,130
+بتلاقيه Stunted يعني في عنده تقزم يعني اللي هو
+
+131
+00:11:45,130 --> 00:11:51,270
+failure to thrive أنه بيكون anemic بيكون عنده
+
+132
+00:11:51,270 --> 00:11:56,090
+hepatosplenomy بيكون عنده hyperpigmentation بيصير
+
+133
+00:11:56,090 --> 00:11:59,830
+عنده crossing of the bones of the face بيكون
+
+134
+00:11:59,830 --> 00:12:04,250
+هيكوجه كل هذه المظاهر للي عندهثلاثة deletions
+
+135
+00:12:04,250 --> 00:12:07,550
+واضحة؟
+
+136
+00:12:07,550 --> 00:12:15,250
+في أسئلة ثانية؟
+
+137
+00:12:15,250 --> 00:12:29,250
+اليوم صراحة محاضرة معجوبة كثير الفصل يعني هنا
+
+138
+00:12:29,250 --> 00:12:35,960
+بتتكلم على الأنواع المختلفةمن الـ Genetic Diseases
+
+139
+00:12:35,960 --> 00:12:42,000
+غير الـ Hemoglobinopathy غير الـ Hemoglobin
+
+140
+00:12:42,000 --> 00:12:47,140
+Anomalies فبالنسبة
+
+141
+00:12:47,140 --> 00:12:56,160
+للـ Spectrum أو الـ Range أو المدى من الـ
+
+142
+00:12:56,160 --> 00:13:00,080
+Conditions اللي بدوا يتكلموا عنها
+
+143
+00:13:03,300 --> 00:13:06,080
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+144
+00:13:06,080 --> 00:13:06,080
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+145
+00:13:06,080 --> 00:13:07,240
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+146
+00:13:07,240 --> 00:13:13,100
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+147
+00:13:13,100 --> 00:13:13,480
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+148
+00:13:13,480 --> 00:13:15,480
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+149
+00:13:15,480 --> 00:13:17,800
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+150
+00:13:17,800 --> 00:13:18,320
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+151
+00:13:18,320 --> 00:13:20,900
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+152
+00:13:20,900 --> 00:13:22,580
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+153
+00:13:29,290 --> 00:13:36,710
+بطريقة ما يحاول يجمع هذه المعلومات ويكون منذكرها
+
+154
+00:13:36,710 --> 00:13:49,630
+الـ Diseases اللي راح نغطيها بالنسبة للمحاضرة هذه
+
+155
+00:13:49,630 --> 00:13:56,970
+مقسمينها عندكم في الكتاب على أساسالـ Cellular
+
+156
+00:13:56,970 --> 00:14:01,850
+Localization وين الخلل
+
+157
+00:14:01,850 --> 00:14:10,250
+في أي مكان فإذا بناخدهم بالترتيب
+
+158
+00:14:10,250 --> 00:14:17,050
+بهذا الشكل الـ first type of diseases are diseases
+
+159
+00:14:17,050 --> 00:14:22,530
+which are in organelles ففيه الـ mitochondrial
+
+160
+00:14:22,530 --> 00:14:29,440
+diseasesأنا بفضل إنه لو هيك نركز على نوع من الـ من
+
+161
+00:14:29,440 --> 00:14:36,380
+الـ Diseases على الأقل، على أساس نتذكر إنه عبارة
+
+162
+00:14:36,380 --> 00:14:45,660
+عن يعني مثال لمرحلة مثل هذه فالـ Mitochondrial
+
+163
+00:14:45,660 --> 00:14:51,250
+Diseases هنا بالـ Oxidative Phosphorylationفي الـ
+
+164
+00:14:51,250 --> 00:14:55,930
+Bayer Hereditary Optical Neuropathy وحكينا الـ
+
+165
+00:14:55,930 --> 00:15:02,570
+«ميتوكندريال» DNA Disease يعني الميتوكندريال فرن
+
+166
+00:15:02,570 --> 00:15:09,750
+الطاقة في الخلية ومصدر الـ ATP اللي بتستخدمه في كل
+
+167
+00:15:09,750 --> 00:15:15,870
+التفاعلات والأنشطة اللي بتقوم فيها الخلية غالبية
+
+168
+00:15:15,870 --> 00:15:23,150
+البروتينات فيها من الـ «ميتوكندريال»الـ DNA أو الـ
+
+169
+00:15:23,150 --> 00:15:29,050
+Mitochondrial chromosome وبالتالي، يعني بننتقل
+
+170
+00:15:29,050 --> 00:15:34,730
+بطريقة معينة عن طريق الأم فقط بينما في الـ
+
+171
+00:15:34,730 --> 00:15:39,810
+Mitochondria itself some other proteins and things
+
+172
+00:15:39,810 --> 00:15:45,770
+needed بتكون لأ حتى بالـ Nuclear DNA يعني أحيانًا
+
+173
+00:15:45,770 --> 00:15:50,530
+الـ Mitochondria نفسها فيها DNA، فيها chromosome
+
+174
+00:15:51,680 --> 00:15:56,500
+نحتاجه، يستخدم، يستفاد منه أو يعني يستخدم ومهم
+
+175
+00:15:56,500 --> 00:15:59,760
+لنفس الـ Mitochondria في الغالب، بس الـ
+
+176
+00:15:59,760 --> 00:16:04,980
+Mitochondria نفسها في بعض الأشياء اللي بتكون يعني
+
+177
+00:16:04,980 --> 00:16:13,000
+كرومزوما في الـ Nuclear DNA Translation of
+
+178
+00:16:13,000 --> 00:16:24,060
+Mitochondrial Diseases يعني فينفس الـ «ميوتاشن» في
+
+179
+00:16:24,060 --> 00:16:29,840
+نفس الـ «ميتوكندريال» الـ «DNA» وفيه، لأ الـ
+
+180
+00:16:29,840 --> 00:16:40,660
+«ميتوكندريال» الـ «DNA» مش كتير خربان ولكن فيه الـ
+
+181
+00:16:40,660 --> 00:16:47,650
+Further steps يكون فيها مشكلةفبتصير في الـ
+
+182
+00:16:47,650 --> 00:16:51,410
+Translation of Mitochondrial Diseases زي مثلًا الـ
+
+183
+00:16:51,410 --> 00:16:59,630
+Sensory Neuronal Deafness الإشي اللي بيسموه حاولت
+
+184
+00:16:59,630 --> 00:17:07,310
+أدور عليها Melas Strokes وLactic Acidosis
+
+185
+00:17:07,310 --> 00:17:13,210
+وMeningoencephalitis يعني إصابة دماغية الكهاب
+
+186
+00:17:13,210 --> 00:17:19,830
+الدماغ والسحايةزائد Lactic Acidosis متابولك
+
+187
+00:17:19,830 --> 00:17:26,310
+أسدوسيز بتكون حالة وهي بتكون شديدة وزائد
+
+188
+00:17:26,310 --> 00:17:29,910
+Picture of a Stroke اللي هي جلطة على الدماغ يعني
+
+189
+00:17:29,910 --> 00:17:36,290
+فهذه الحالة بتكون أحيانًا نتيجة خلل في الـ
+
+190
+00:17:36,290 --> 00:17:40,040
+Translation of the mitochondrial diseasesفيه إيش
+
+191
+00:17:40,040 --> 00:17:45,680
+اسمه الـ Paroxysomes زي إيش اسمه الـ Zolliger
+
+192
+00:17:45,680 --> 00:17:50,620
+Syndrome بالأول فكرتها Zolliger Syndrome الـ
+
+193
+00:17:50,620 --> 00:17:54,320
+Zolliger اللي بنون هذا الـ disease بيكون
+
+194
+00:17:54,320 --> 00:18:02,980
+Hypersecretion of Gastrin ويصير عندي زي Gastrinoma
+
+195
+00:18:02,980 --> 00:18:11,190
+ويكونأو كده وكده، لا، هيزوليجر عبارة عن الـ
+
+196
+00:18:11,190 --> 00:18:15,610
+neurological condition فيه الـ lysosomal disease
+
+197
+00:18:15,610 --> 00:18:20,930
+نتيجة الخلل في الـ lysosomal enzymes الـ lysosomal
+
+198
+00:18:20,930 --> 00:18:27,230
+enzymes عبارة عن الليسوزوم هو يعني بالذات للـ
+
+199
+00:18:27,230 --> 00:18:30,110
+phagocytes في المناعة عبارة عن
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ofPBC5zCpyc_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ofPBC5zCpyc_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..7476886b97c7422e5d28e0385d3b9ddf2273e11f
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ofPBC5zCpyc_postprocess.srt
@@ -0,0 +1,3492 @@
+1
+00:00:00,000 --> 00:00:03,860
+affected مش كامل، mild يعني مش صحيح زي اللي بيكون
+
+2
+00:00:03,860 --> 00:00:16,140
+اللي هو homozygous شوف، يعني المبدأ لموضوع إنه
+
+3
+00:00:16,140 --> 00:00:22,840
+autosomal dominant ماشي المبدأ إنه هو اللي بيظهر
+
+4
+00:00:22,840 --> 00:00:31,100
+بس على شرط إن الصفر هذه تعتمد فقطعلى جين واحد
+
+5
+00:00:31,100 --> 00:00:38,180
+أحيانًا الأمور أعقد من هيك واللي هو بنبدأ ندخل
+
+6
+00:00:38,180 --> 00:00:42,920
+أكتر في الـ Polygenic اللي كنا نتكلم عنه قبل شوية
+
+7
+00:00:42,920 --> 00:00:47,940
+الأسبوع، مش المحاضرة اللي فاتت، اللي قبلها لما
+
+8
+00:00:47,940 --> 00:00:55,700
+نكون أكتر من جين وEpigenetic Control وكده وهيك ففي
+
+9
+00:00:55,700 --> 00:01:01,680
+أحيانًا الـ Dominanceبيرتبط بـ Sticks حكينا مثال
+
+10
+00:01:01,680 --> 00:01:07,560
+الصلع الصلع في جين معين في الذكور dominant في الـ
+
+11
+00:01:07,560 --> 00:01:11,600
+females recessive يعني مش دايماً لما نقول dominant
+
+12
+00:01:11,600 --> 00:01:16,060
+يعني دايماً dominant وفي كل الحالات dominant وكذا
+
+13
+00:01:16,060 --> 00:01:20,580
+حتى لو إنه على الـ autosomal genes يعني ما هو مش
+
+14
+00:01:20,580 --> 00:01:24,640
+على الـ sex linked genes هدولة بس مرتبط بالجنة
+
+15
+00:01:24,640 --> 00:01:30,920
+فالآن في صفتينإضافيات على كلمة الـ Dominant بدت
+
+16
+00:01:30,920 --> 00:01:36,600
+تفهم إنه أحيانًا Dominance بيسموه مش كامل يعني
+
+17
+00:01:36,600 --> 00:01:45,280
+صحيح هو موجود بس مش 100% يعني مش هيظهر في 100% من
+
+18
+00:01:45,280 --> 00:01:51,400
+الناس أو 100% من الدرجة الشدة يعني ممكن يكون مثلًا
+
+19
+00:01:51,400 --> 00:01:55,780
+واحد اللي عنده الأتزامة الـ Dominant إذا فرضنا صفة
+
+20
+00:01:55,780 --> 00:02:01,670
+معينةبتلاقيها طارت 100% بينما ممكن و الـ
+
+21
+00:02:01,670 --> 00:02:05,990
+heterozygous بتتوقع أنه يكون 50% مثلا عنده مثلًا
+
+22
+00:02:05,990 --> 00:02:11,630
+نفترض إشي معين فاللي بتلاقيه autosomal dominance
+
+23
+00:02:11,630 --> 00:02:18,590
+بتلاقي incomplete penetrance يعني ما بيظهر بشكل
+
+24
+00:02:18,590 --> 00:02:25,070
+كامل يعني ممكن ما يظهرش و في العكس ممكن اتغير
+
+25
+00:02:25,070 --> 00:02:31,270
+النسباللي تشوفه إنه لو autosomal dominance و
+
+26
+00:02:31,270 --> 00:02:38,390
+lethal يعني مرض شديد كتير كتير كتير بحيث إنه ما في
+
+27
+00:02:38,390 --> 00:02:43,770
+إنسان يولد فيه بعيش سواء في فترة الـ embryonic
+
+28
+00:02:43,770 --> 00:02:48,910
+period أو الجن أو يعني فيتغير النسب اللي بتلاقيها
+
+29
+00:02:48,910 --> 00:02:53,180
+فاهم عليك كده؟ففيه Lethal وDominant في بعضها
+
+30
+00:02:53,180 --> 00:02:57,400
+Lethal وبعضها Incomplete Venetrance والأصل الـ
+
+31
+00:02:57,400 --> 00:03:04,440
+Classical اللي أنت بهيك كمفهوم عام بيقول إنه الـ
+
+32
+00:03:04,440 --> 00:03:10,560
+Trait هادي أو الصفة هادي بهذا الشكل هي الـ
+
+33
+00:03:10,560 --> 00:03:14,880
+Dominant فمعناه كذا، فهذا المقصود بمثل هيك أشياء
+
+34
+00:03:14,880 --> 00:03:21,240
+بفرجوكي إياها الآن بدك ترجع تفهم مرة ثانية شغلةحتى
+
+35
+00:03:21,240 --> 00:03:27,080
+لما اتكلمنا بنأول على موضوع اللي
+
+36
+00:03:27,080 --> 00:03:35,540
+هو اللي بيسموه الـ Reference Sequence أنت تتكلم عن
+
+37
+00:03:35,540 --> 00:03:38,840
+أحيانًا دراسة معينة عملوها في لحظة معينة على
+
+38
+00:03:38,840 --> 00:03:45,740
+مجموعة معينة على عيلة معينة، كده فضمن هذه المعطيات
+
+39
+00:03:45,740 --> 00:03:52,250
+اللي هي هذه العيلةكان الظاهرة
+
+40
+00:03:52,250 --> 00:03:55,970
+الموجودة واللي بحثناها بهذا الشكل فبنستنتجها
+
+41
+00:03:55,970 --> 00:04:00,870
+والاستنتاج فاهم عليك كده؟ فانت كلمة «dominant» لا
+
+42
+00:04:00,870 --> 00:04:06,030
+تعني dominant مطلق هيك نفس المستوى لكل الجينات وكل
+
+43
+00:04:06,030 --> 00:04:12,330
+العائلات وكل الناس، لأ، بتلاقي الأمر، إيش اسمه،
+
+44
+00:04:12,330 --> 00:04:19,950
+فيه تفاوضفي أسئلة أخرى إن شاء الله أجاوب عليها بس
+
+45
+00:04:19,950 --> 00:04:26,930
+خليني أسأل أسئلة بقى نعم أسأل سؤال تاني بس أتفضل،
+
+46
+00:04:26,930 --> 00:04:28,190
+أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل،
+
+47
+00:04:28,190 --> 00:04:31,090
+أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل،
+
+48
+00:04:31,090 --> 00:04:31,110
+أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل،
+
+49
+00:04:31,110 --> 00:04:39,150
+أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أ
+
+50
+00:04:40,730 --> 00:04:44,670
+وهذا بيكون complete، اللي هو مثلا نفترض إنه دي دي
+
+51
+00:04:44,670 --> 00:04:50,610
+كcapital والناس ال male اللي مش maintain و ال
+
+52
+00:04:50,610 --> 00:04:56,790
+female برضه هادة نفترض إنها Tigers، لإنه ممكن تكون
+
+53
+00:04:56,790 --> 00:05:00,630
+دي قدر المسموعة ‏-أنا أتبقى من ال picture ‏-صحيح؟
+
+54
+00:05:00,630 --> 00:05:05,730
+‏-اشو، اسمع علي، بس كافي عن الصحيحة
+
+55
+00:05:09,080 --> 00:05:14,240
+الـ «إيه» أنا مش شايفها، شايف اللي حاطف عليها
+
+56
+00:05:14,240 --> 00:05:21,520
+«إيه» وين 100% بيكون، بس الـ «بديجري» اللي تبع
+
+57
+00:05:21,520 --> 00:05:26,900
+العيلة هذه «أكندروبلازيا»، «incompletely dominant
+
+58
+00:05:26,900 --> 00:05:31,400
+trait»، بكون لما أنا شوف انت عنيه؟ أنا و«جزوف»
+
+59
+00:05:31,400 --> 00:05:36,700
+بتتكلم عنه؟ عن
+
+60
+00:05:36,700 --> 00:05:48,120
+صوت بيه؟B ما لها؟ ماشي الـ الـ الان شو المشكلة هنا
+
+61
+00:05:48,120 --> 00:05:55,180
+المشكلة إنه إذا هذا الـ dominant و أثنين أشخاص
+
+62
+00:05:55,180 --> 00:06:06,600
+عندهم أكندربلازيا، ماشي؟ ماشي الحال معايا؟ إذا كان
+
+63
+00:06:09,080 --> 00:06:17,200
+طيب خلّيني ا share screen خلّيني
+
+64
+00:06:17,200 --> 00:06:20,440
+ا .. بس عشان لأنهم بيسألوا شو الصورة اللي بنحكي
+
+65
+00:06:20,440 --> 00:06:28,280
+عنها بحكي لصورة زي هيك ال .. ده .. الأعناء هي عالي
+
+66
+00:06:28,280 --> 00:06:42,480
+ودول اثنين يعني ال .. اثنين همزلمة ومرة عندهم
+
+67
+00:06:42,480 --> 00:06:47,220
+أكندربلازيا وكانت أنا فحصتهم ولقيتهم dominant
+
+68
+00:06:47,220 --> 00:06:55,260
+ولقيت two copies الأصل لو فيه two copies ماشي يعني
+
+69
+00:06:55,260 --> 00:07:00,260
+لو بقدر واحد يحسبها لو واحد بس شخص مصعب الاحتمالي
+
+70
+00:07:00,260 --> 00:07:04,660
+المفروض تكون نص بس إذا اثنين مصعبين لازم تكون أكتر
+
+71
+00:07:04,660 --> 00:07:12,100
+واحتمالواحد منهم كان يعني يعني ده اثنين اتزوجوا
+
+72
+00:07:12,100 --> 00:07:21,820
+هيك ليش الفرد هذا البنت هذه طلعت طبيعية ماشي فالآن
+
+73
+00:07:21,820 --> 00:07:29,400
+يعني أنا اللي بتحكيلكيها لصور زي هيك بدك تدخل يعني
+
+74
+00:07:29,400 --> 00:07:34,260
+صعب أكتر أشرحلك يعني ده المبدأ أنت فاهمه من ناحية
+
+75
+00:07:34,850 --> 00:07:37,790
+ماذا يعني Dominant؟ ماذا يعني Resistive؟ ماذا يعني
+
+76
+00:07:37,790 --> 00:07:41,450
+Autosomal؟ وماذا يعني الـ X-Links؟ الـ Patterns
+
+77
+00:07:41,450 --> 00:07:45,630
+للـ Inheritance، إذا أنت فاهمها الآن هنا إثنين
+
+78
+00:07:45,630 --> 00:07:50,430
+مصابين، كيف يطلع لهم ابن طبيعي؟ هذا يجب أن يكون
+
+79
+00:07:50,430 --> 00:07:54,470
+الواحد يتكلم على إنه فيه Incomplete Dominance
+
+80
+00:07:54,470 --> 00:07:58,490
+ماشي، أو Semi-dominant trait، يعني هذا كنوع من
+
+81
+00:07:58,490 --> 00:08:03,830
+التفسير ممكن إنهم إثنين هم Heterozygous، وهذا طلع
+
+82
+00:08:04,280 --> 00:08:12,820
+من الـ Recessive trait شو اسمه اللي هنا Normal
+
+83
+00:08:12,820 --> 00:08:17,740
+طلعت واحدة منهم يعني اللي هي الرُبع لما نكون
+
+84
+00:08:17,740 --> 00:08:21,700
+Recessive trait بس هذه الـ Recessive trait هنا
+
+85
+00:08:21,700 --> 00:08:27,020
+بمعنى إن الـ Disease هو dominant فالـ Normal هو
+
+86
+00:08:27,020 --> 00:08:32,300
+الـ Recessive فبيّن إشي أو إنه يمكن هذا شخص عنده
+
+87
+00:08:32,300 --> 00:08:36,850
+الـ Geneبس مش مبين لأنه مش Completely Dominant
+
+88
+00:08:36,850 --> 00:08:41,370
+Incompletely Dominant يعني أو Semi-dominant فاهم
+
+89
+00:08:41,370 --> 00:08:48,290
+عليك كده؟ فالآن يعني ما بتقدر يعني خد الفكرة من
+
+90
+00:08:48,290 --> 00:08:53,690
+الـ Pedigree الـ Pedigree العيلة هدولة عيلتين
+
+91
+00:08:53,690 --> 00:09:01,730
+مختلفتين صار فيهم mutation لموقع
+
+92
+00:09:01,730 --> 00:09:08,360
+معينسوّت هذا المرض شخصين عندما دول المرض اتزوجوا
+
+93
+00:09:08,360 --> 00:09:14,220
+الأصل أنه كل ولادهم بناتهم يكونوا يعني مش كلهم بدل
+
+94
+00:09:14,220 --> 00:09:19,220
+واحد 75% على الأقل يطلعوا إذا أثنانهم بيكونوا
+
+95
+00:09:19,220 --> 00:09:29,670
+heterozygous بيطلعوا affected وده أنت درستعلى
+
+96
+00:09:29,670 --> 00:09:36,610
+موضوع شو اسمه درست على موضوع المستوى الجيني بتلاقي
+
+97
+00:09:36,610 --> 00:09:39,970
+أحيانًا ممكن الجين المصاب عند هذا الشخص بصي شيء
+
+98
+00:09:39,970 --> 00:09:46,730
+مبين عليه هذه النقطة – صحيح – ماشي نكمل – خليني بس
+
+99
+00:09:46,730 --> 00:09:50,150
+أسأل الـ type عندها و نشوف صح و لا خطأ – إيش هو؟ –
+
+100
+00:09:50,150 --> 00:09:53,330
+لإن أنا أسفة تقريبًا مصدش، بدي أكتب الـgenotype و
+
+101
+00:09:53,330 --> 00:09:56,250
+أنت شوف صح و لا خطأ، تقريبًا سؤالي مصدش – أنا
+
+102
+00:09:56,250 --> 00:10:05,070
+الصورة هنا الـM شايفةالـ «إيه» مش شايفة «هل دي
+
+103
+00:10:05,070 --> 00:10:11,270
+كمتل» «هل دي كمتل» «هل
+
+104
+00:10:11,270 --> 00:10:20,390
+دي كمتل» «هل دي كمتل» «هل دي كمتل» «هل دي كمتل»
+
+105
+00:10:20,390 --> 00:10:21,490
+«هل دي كمتل» «هل دي كمتل» «هل دي كمتل» «هل دي
+
+106
+00:10:21,490 --> 00:10:23,150
+كمتل» «هل دي كمتل» «هل دي كمتل» «هل دي كمتل» «هل
+
+107
+00:10:23,150 --> 00:10:24,790
+دي كمتل» «هل دي كمتل» «هل دي كمتل» «هل دي كمتل»
+
+108
+00:10:24,790 --> 00:10:27,370
+«هل دي كمتل» «هل دي كمتل» «هل دي كمتل» «هل دي
+
+109
+00:10:27,370 --> 00:10:29,410
+كمتل» «ه
+
+110
+00:10:32,880 --> 00:10:36,420
+اللي بتوفي هاد، مكتوب في السؤال «dominant
+
+111
+00:10:36,420 --> 00:10:40,940
+-complete»، فمعدل ولادة مباشرة، إنما الليل اللي مش
+
+112
+00:10:40,940 --> 00:10:43,860
+توفي هاد، هذا «incomplete-dominant»، فبقى عايش حتى
+
+113
+00:10:43,860 --> 00:10:48,500
+الآن. بفهم من هيك إن الأم هدولة بيكونوا
+
+114
+00:10:48,500 --> 00:10:51,880
+«incomplete-dominant»، والدليل إنه أعطوا بنت خانة
+
+115
+00:10:51,880 --> 00:10:55,200
+مش مصالبة من الأساس، فمتوقع إن هد بيكون مثلًا
+
+116
+00:10:55,200 --> 00:11:00,000
+«decapital»، «de-small»،«welcome to this world» و
+
+117
+00:11:00,000 --> 00:11:03,700
+«this world» و «this world» منهم اللي هو الصفة
+
+118
+00:11:03,700 --> 00:11:07,860
+المفترضة صحيح، ما هي اللي كنت حاولتها صحيح؟ آه،
+
+119
+00:11:07,860 --> 00:11:12,220
+صحيح أنا بدي أسأل الفكرة هذه، إنه الأب، الميل،
+
+120
+00:11:12,220 --> 00:11:18,680
+والأبوين، بالنسبة لهذا، الأصل تبعهم فوق، مفيش فيه
+
+121
+00:11:18,680 --> 00:11:22,320
+إصابات، يعني هم مفيش إصابة بالمرة، كيف هروصلتهم
+
+122
+00:11:22,320 --> 00:11:27,700
+الإصابة، خاصة الطلين؟ آه، آهوهذه إذا كانت عندهم
+
+123
+00:11:27,700 --> 00:11:31,200
+الصفحة هان فطبيعي لازم تكون ظاهرة عند أحد الأبوين
+
+124
+00:11:31,200 --> 00:11:39,320
+فورا وبالتالي شو ال conclusion؟ إن هدول بشر صارت
+
+125
+00:11:39,320 --> 00:11:44,720
+عندهم ال mutation هي بدأت in بضبط أنا بس ال
+
+126
+00:11:44,720 --> 00:11:48,520
+mutation طلعت عند الأب و الأم فمان مع بعض صحيح؟
+
+127
+00:11:48,520 --> 00:11:52,740
+إيش هو؟ ال mutation طلعت عند الأب و الأم مع بعض
+
+128
+00:11:52,740 --> 00:11:58,280
+اللي هو الجيل الثاني أه أه أههو هنا يعني عيلتين
+
+129
+00:11:58,280 --> 00:12:03,380
+أكندرو بلايزيا بتعرف صورتهم كيف حجم جسمهم طبيعي بس
+
+130
+00:12:03,380 --> 00:12:08,220
+أطرافهم قصيرة جدا فبكونوا بالـ Circus بكونوا
+
+131
+00:12:08,220 --> 00:12:14,040
+بالأفلام بتشوفهم أحيانا كذا ولا هيك لو من عيلتين
+
+132
+00:12:14,040 --> 00:12:19,720
+مختلفتين شخصين بهذه الصفات حبوا بعض و اتجوزوا بعض
+
+133
+00:12:19,720 --> 00:12:27,320
+بتصير فاهم عليك؟ ألا لما يكونوا زي هيتوقعنا إنه
+
+134
+00:12:27,320 --> 00:12:34,900
+الـ 75% من الـ من الأطفال
+
+135
+00:12:34,900 --> 00:12:39,860
+اللي بيطلعوا راح يكونوا برضه أكندربلازيا ماشي،
+
+136
+00:12:39,860 --> 00:12:43,280
+واللي
+
+137
+00:12:43,280 --> 00:12:51,980
+عنده 25% اللي هي الـ 25% اللي هي الـ Double اللي
+
+138
+00:12:51,980 --> 00:12:57,180
+بيكون homozygous، dominantيمكن يكون lethal فاهم
+
+139
+00:12:57,180 --> 00:13:05,000
+عليك كيف؟ فبالتالي بيعيشش هذا مفتوح دكتور أه بس في
+
+140
+00:13:05,000 --> 00:13:08,820
+مفتوح ثاني برضه مش في هذه الصورة هلجيتها في جزيرة
+
+141
+00:13:08,820 --> 00:13:16,480
+ال X inactivation عند الفميل؟ نعم ممكن هو يعمل X
+
+142
+00:13:16,480 --> 00:13:18,900
+inactivation لبعض الجنة مش كله يعمل X inactivation
+
+143
+00:13:18,900 --> 00:13:25,270
+إيه شو؟الـ Chromosome X لما يحصل Deactivation عند
+
+144
+00:13:25,270 --> 00:13:28,370
+الثمن آه، مش كله بيحصل Deactivation بيحصل
+
+145
+00:13:28,370 --> 00:13:33,530
+Expiration لبعض جينات المنسية لأ، المقصود في الـ
+
+146
+00:13:33,530 --> 00:13:40,550
+Random Deactivation للجينات
+
+147
+00:13:40,550 --> 00:13:45,530
+اللي احنا بنحكي عنه الـ Ionization بتلاقي الجين
+
+148
+00:13:45,530 --> 00:13:52,540
+كامل مش شغال، مش مفروضكيف شكله على الميكروسكوب لما
+
+149
+00:13:52,540 --> 00:13:58,520
+تتطلع عليه لما قعدنا نفحص اللي بيكون بار بيديز
+
+150
+00:13:58,520 --> 00:14:05,220
+ماشي في الـ meiosis و الـ mitosis أو الـ mitosis
+
+151
+00:14:05,220 --> 00:14:12,220
+في الـ meiosis في الفيميل بيكون بيسموه في إيه إشي
+
+152
+00:14:12,220 --> 00:14:17,340
+بيسموه الـ polar body هذا بيكون خلية كاملة هي
+
+153
+00:14:17,340 --> 00:14:23,190
+نفسها بتكون زي النقطةأما بالنسبة للـ X-Chromosome
+
+154
+00:14:23,190 --> 00:14:29,270
+بتلاقي بشكل عشوائي مرة هاد ومرة هاد، ما هو ما فيه
+
+155
+00:14:29,270 --> 00:14:35,850
+اتنين بالـ Female واحد بس شغال والتاني مسكر فاهم
+
+156
+00:14:35,850 --> 00:14:41,670
+عليك كيف؟ فبنشوفه لما تعمل Bar Body Study بتشوف
+
+157
+00:14:41,670 --> 00:14:46,260
+النقطة تبع الـ X-Chromosome وبكون Inactive كلهمش
+
+158
+00:14:46,260 --> 00:14:49,920
+بعض الجينات شغالة من هذا وبعض الجينات شغالة من هذا
+
+159
+00:14:49,920 --> 00:14:53,320
+واضح؟
+
+160
+00:14:53,320 --> 00:15:01,960
+طيب، في أسئلة كمان أنا بقترح اكتبوا الأسئلة
+
+161
+00:15:01,960 --> 00:15:07,540
+وخلّينا سواء بأول المحاضرة أو بآخر المحاضرة نحطهم
+
+162
+00:15:07,540 --> 00:15:17,270
+كلهم وش اسمه؟ ويعني نشوف، ماشي؟دكتور في سؤال من
+
+163
+00:15:17,270 --> 00:15:23,030
+دكتور علمازي قول شو الفرق بين ال semi-dominant و
+
+164
+00:15:23,030 --> 00:15:27,990
+ال pure-dominant و ال co-dominant ال co-dominant
+
+165
+00:15:27,990 --> 00:15:34,990
+لما ال two traits بتكون زي بعض رأس برأس اتنين هم
+
+166
+00:15:34,990 --> 00:15:41,950
+بتظهروا يعني زي ال ABO system ال A و ال B على بعض
+
+167
+00:15:41,950 --> 00:15:47,490
+co-dominant يعنيلو واحد عنده A و B، إثنين بدهم
+
+168
+00:15:47,490 --> 00:15:52,410
+يظهروا تبعتهم، فاهم عليك كيف؟ فهذه الإسمة Co
+
+169
+00:15:52,410 --> 00:15:59,910
+-dominant أما الـ A و الـ O أو الـ B و الـ O الـ A
+
+170
+00:15:59,910 --> 00:16:04,810
+و الـ B هم الـ dominant على الـ O يعني الـ O مافيش
+
+171
+00:16:04,810 --> 00:16:11,710
+منه إشي، مابيبينش إشي فيه فبالتالي بكون بس الـ A
+
+172
+00:16:11,710 --> 00:16:20,670
+أو الـ B هو اللي موجودماشي، فشو اسمه؟
+
+173
+00:16:20,670 --> 00:16:24,330
+يعني
+
+174
+00:16:24,330 --> 00:16:32,930
+شو اسمه؟ الأن الموضوع الثالث أنه حتى لو dominant
+
+175
+00:16:32,930 --> 00:16:40,950
+أحياناً درجاته بتختلف وإذا هنا يعني درجاته بتختلف
+
+176
+00:16:41,460 --> 00:16:47,140
+بصير الواحد كأنه بدي يدخل على مواضيع الـ Polygenic
+
+177
+00:16:47,140 --> 00:16:52,140
+Disorders يعني يمكن يكون الصفة هذه أكثر من جين
+
+178
+00:16:52,140 --> 00:16:56,180
+بتحكم فيها مش جين واحد اللي أنا بدرسه فاهم عليك
+
+179
+00:16:56,180 --> 00:17:02,780
+كيف؟ فكلمة Incomplete Dominance أو Lethal أو أنواع
+
+180
+00:17:02,780 --> 00:17:11,410
+ثانية بتتكلم على يعني variationتغييرها على يعني في
+
+181
+00:17:11,410 --> 00:17:17,390
+أن بعض الجينات ما بتكون 100% Classical هذا يُعطى
+
+182
+00:17:17,390 --> 00:17:22,670
+كنوع من التفسير لظاهر أحنا بنشوفها فاهم عليك كيف؟
+
+183
+00:17:22,670 --> 00:17:28,390
+بحيث أن أحيانًا بكون الـdominance مش كامل أدل إن
+
+184
+00:17:28,390 --> 00:17:35,070
+واحد يصله في أسئلة كمان؟ خلّينا نمشي في المحاضرة
+
+185
+00:17:36,980 --> 00:17:42,480
+وكل الأسئلة يعني إذا بنحطها على الـ Group بتكون
+
+186
+00:17:42,480 --> 00:17:50,880
+بشكل أوضح بالذات كـ Concept إذا فيها مشكلة يعني
+
+187
+00:17:50,880 --> 00:17:56,160
+بنتكلم عنها البداية
+
+188
+00:17:56,160 --> 00:18:03,100
+المحاضرة اليوم بتعطيكم homework خدوه وش اسمه يعني
+
+189
+00:18:03,100 --> 00:18:10,990
+فكروا فيهوالأسبوع الجاي بنحله وبنشوف شو الـ الـ
+
+190
+00:18:10,990 --> 00:18:21,490
+نتاج سبحته الملخص المحاضرة اللي فاتت أنه الـ الـ
+
+191
+00:18:21,490 --> 00:18:26,990
+في حالة الـ steady state في حالة أنه مافيش هجرات
+
+192
+00:18:26,990 --> 00:18:33,640
+مافيش mutations مافيش يعنيسيلكشن في الزواج لمجموعة
+
+193
+00:18:33,640 --> 00:18:39,560
+معينة دون أن عن الأخرى الـ Frequency لـ الـ Two
+
+194
+00:18:39,560 --> 00:18:45,940
+Alleles اللي بدنا نشتغل عليهم بيكون الـ P و الـ Q
+
+195
+00:18:45,940 --> 00:18:53,960
+و P و Q مجموعهم يساوي واحد اللي هي نسبة اللي
+
+196
+00:18:53,960 --> 00:18:57,740
+موجودة في الـ Population والمثال اللي حطوه الـ
+
+197
+00:18:57,740 --> 00:19:08,050
+CCR5الـ Mutated CCR5 Receptor Mutations اللي حكينا
+
+198
+00:19:08,050 --> 00:19:14,550
+عنها فالمعادلة الثانية، بدنا نتذكر إن واحد يساوي B
+
+199
+00:19:14,550 --> 00:19:20,430
+تربيع زائد اثنين BQ زائد Q تربيع هذولة المحاضرتين،
+
+200
+00:19:20,430 --> 00:19:24,650
+هذولة المعدلتين أنا بتوقع يعني مهمات كثير، الواحد
+
+201
+00:19:24,650 --> 00:19:30,490
+يفهمهمفأنا بدي أعقد الموضوع وأعطيكم إياه إمتحان أو
+
+202
+00:19:30,490 --> 00:19:36,690
+سؤال لنشوف للأسبوع اللي جاي يشتغلوا عليه أنتم
+
+203
+00:19:36,690 --> 00:19:39,810
+ويعطوني
+
+204
+00:19:39,810 --> 00:19:47,890
+الـ Results تبعتكم أفرض أنا مسكتكم كلكم 200 طالب
+
+205
+00:19:47,890 --> 00:19:56,040
+وطالبة وفحصت الـ ABO Systemالـ A-type في الـ
+
+206
+00:19:56,040 --> 00:20:00,740
+medical students in Islamic University of Gaza and
+
+207
+00:20:00,740 --> 00:20:05,440
+found the frequencies as are follows الـ A-type 20
+
+208
+00:20:05,440 --> 00:20:13,980
+% الـ B-type 24% الـ A-B-type 26% الـ O-type 30%
+
+209
+00:20:13,980 --> 00:20:19,660
+فالسؤال What are the frequencies of the alleles in
+
+210
+00:20:19,660 --> 00:20:28,510
+this population؟هنا عقدت الموضوع زيادة يعني لو الـ
+
+211
+00:20:28,510 --> 00:20:38,250
+AB كان كله يعني الـ AB لو إنه كان موجود بهذا الشكل
+
+212
+00:20:38,250 --> 00:20:44,250
+يعني لو كان كروموزومت أليل واحد كانت راح تكون
+
+213
+00:20:44,250 --> 00:20:48,770
+تماماً Classical حسب المعادلات بس هنا أنا حطيت
+
+214
+00:20:48,770 --> 00:20:50,830
+الأثنين فكروا فيها
+
+215
+00:20:53,690 --> 00:21:00,310
+لكل قليل اللي هو الـ A والـ B والـ O أعطيني الـ
+
+216
+00:21:00,310 --> 00:21:11,390
+Frequency تبعتهم الآن محاضرت اليوم يعني
+
+217
+00:21:11,390 --> 00:21:17,410
+كيف أنا بدي أفهم العلاقة
+
+218
+00:21:17,410 --> 00:21:21,030
+الوراثة
+
+219
+00:21:21,030 --> 00:21:27,700
+والـالـ Genetics تبعات أي إنسان وبين إنه يحدث معاه
+
+220
+00:21:27,700 --> 00:21:33,820
+مرض طبعاً يعني بتتدخل فيها مواضيع كثيرة والأمر
+
+221
+00:21:33,820 --> 00:21:39,860
+يعني أحياناً
+
+222
+00:21:39,860 --> 00:21:46,560
+حتى الواحد يشوفه بتكون فيه ظواهر كثيرة يعني قضايا
+
+223
+00:21:46,560 --> 00:21:56,540
+مهمة بالنسبة لـجزء من الـ الـ يعني احنا الأسهل
+
+224
+00:21:56,540 --> 00:22:01,480
+أحيانًا كتير بنتكلم عن الـ الـ الـ الجين الواحد
+
+225
+00:22:01,480 --> 00:22:07,840
+على إنه هذا من الأب و هذا من الأم على كرموزوم كامل
+
+226
+00:22:07,840 --> 00:22:16,440
+وإن الأمور يعني كل كرموزوم بيظلوا زي ما هو الحقيقة
+
+227
+00:22:16,440 --> 00:22:25,630
+أعقد من هيك بكتير أحيانًااللي بيصير إنه لو أخذنا
+
+228
+00:22:25,630 --> 00:22:32,710
+الجيل الأجداد، الجيل الأول ذكروا أنثى، اتزوجوا،
+
+229
+00:22:32,710 --> 00:22:36,650
+وإذا افترضنا كل واحد منهم كان الـChromosome تبعه
+
+230
+00:22:36,650 --> 00:22:43,310
+بهذا الشكل ولوّننا على إن هاي الـTwo copies تبعات
+
+231
+00:22:43,310 --> 00:22:50,260
+الجينات تبعات هذا الإنسان في هذا الموقعوعنا كل
+
+232
+00:22:50,260 --> 00:22:56,640
+واحد منها Two copies لما أنا باجي بدرس ترتيب
+
+233
+00:22:56,640 --> 00:23:06,380
+الجينات تبعات الأبناء والبنات ماشي أحياناً يعني
+
+234
+00:23:06,380 --> 00:23:14,620
+باعتمد على بالذات إذا الأماكن بعيدة عن بعض ماشي،
+
+235
+00:23:14,620 --> 00:23:19,500
+في الـ DNAبلاقي إنه بتصير ظاهرة بنسميها الـ
+
+236
+00:23:19,500 --> 00:23:27,000
+recombination الـ recombination إنه بيصير خلال
+
+237
+00:23:27,000 --> 00:23:34,940
+فترات الـ cell division بيبدأ تكون بالـ gametes
+
+238
+00:23:34,940 --> 00:23:40,520
+يعني بالـ ova و بالـ sperms لما يصير عملية الـ
+
+239
+00:23:40,520 --> 00:23:45,680
+segregation لما يصير عملية الانفصال
+
+240
+00:23:46,020 --> 00:23:53,160
+الـ Two copies عن بعضها، ماشي؟
+
+241
+00:23:53,160 --> 00:23:56,220
+شو
+
+242
+00:23:56,220 --> 00:24:05,000
+اسمه؟ بالنسبة ل، لو فرضنا هنا، هاي بدهم يطلعوا على
+
+243
+00:24:05,000 --> 00:24:14,240
+الـDNA بالذات للـX-Chromosome مثلا بالنسبة للإنسان
+
+244
+00:24:14,240 --> 00:24:22,740
+هذابنلاقي إنه صحيح حجم الـ «DNA» كاملاً هيك متساوي
+
+245
+00:24:22,740 --> 00:24:25,920
+ويعني
+
+246
+00:24:25,920 --> 00:24:35,420
+متشابه بس حقيقةً في قطع في كل كروموزوم بيكون من
+
+247
+00:24:35,420 --> 00:24:44,580
+الـ يعني من النسختين اللي قبل يعني هسة الـ «high»
+
+248
+00:24:44,780 --> 00:24:52,520
+الصور الأصلية للـChromosomes تبعات ذكر الأمتى
+
+249
+00:24:52,520 --> 00:25:01,940
+عندما نأخذ البنت الأولى هذا الـChromosome أخذته من
+
+250
+00:25:01,940 --> 00:25:10,400
+أبوها بس صحيح كان في الغالبهذه النسخة من الـ
+
+251
+00:25:10,400 --> 00:25:17,480
+Chromosome هذا ما هي اللي أخذته؟ بس في البنت بعض
+
+252
+00:25:17,480 --> 00:25:25,780
+القطع من الجينات من النسخة الثانية، ماشي؟ وهي
+
+253
+00:25:25,780 --> 00:25:30,300
+نتيجة أن بين هذه وهذه النسختين إن شاء الله أنكم
+
+254
+00:25:30,300 --> 00:25:34,200
+بتشوفوا المؤشر اللي بتكلم عنه صارت عملية
+
+255
+00:25:34,200 --> 00:25:39,430
+Recombination يطلعليالـ Chromosome من الأب بهذا
+
+256
+00:25:39,430 --> 00:25:44,910
+الشكل فيه الغالبين العظمى الأصل لهذا الـ
+
+257
+00:25:44,910 --> 00:25:49,790
+Chromosome بس أخد شوية من القطع من الـ Chromosome
+
+258
+00:25:49,790 --> 00:25:56,950
+الثاني هذه ظاهرة بنسميها Recombination يعني
+
+259
+00:25:56,950 --> 00:26:05,050
+بالذات إذا الـ Chromosome طويلوكان يعني من
+
+260
+00:26:05,050 --> 00:26:09,490
+الكرموزومات الكبيرة مش الصغيرة بتلاقي إن الظاهرة
+
+261
+00:26:09,490 --> 00:26:15,150
+هذه بتكون نسبتها أعلى ويكون إنها بتحدث وبتكون إنه
+
+262
+00:26:15,150 --> 00:26:21,850
+ما بنفصل هذولة تماماً عن بعض بشكل مستقل تماماً
+
+263
+00:26:21,850 --> 00:26:29,770
+وإنما وإنما بيصير عملية Recombination وهي في كل
+
+264
+00:26:30,110 --> 00:26:39,170
+الجينات ولكل الكرموزومات بحيث إنه لما نصل بعد ثالث
+
+265
+00:26:39,170 --> 00:26:48,110
+generation حقيقة إذا بنلاحظ هنا إنه لما نيجي نربط
+
+266
+00:26:48,110 --> 00:26:56,890
+الكرموزوم تبع الجيل الثالث الواحد منهم موجود في
+
+267
+00:26:56,890 --> 00:27:06,980
+خواصالأربع كروموزومات من الأبوين من الجدين في نفس
+
+268
+00:27:06,980 --> 00:27:14,800
+الكروموزوم فأتأمل أن هذه الخطيئة واضحة أنه عند الـ
+
+269
+00:27:14,800 --> 00:27:21,580
+Cell Division وبالذات في الـ Gametes عشان يتم
+
+270
+00:27:21,580 --> 00:27:29,750
+نقلها يكون هناك اشتراكوعملية ظاهرة الـ
+
+271
+00:27:29,750 --> 00:27:35,010
+Recombination هي كمان ظاهرة مهمة على مستوى الـ
+
+272
+00:27:35,010 --> 00:27:42,530
+Chromosome بس بتأثر على يعني شو المادة الوراثية
+
+273
+00:27:42,530 --> 00:27:49,590
+اللي بيأخذها أي ابن أو بنت من أبائه وأمهاته
+
+274
+00:27:49,590 --> 00:27:54,010
+واجداده بالطريقة هذه فهنا، ظاهرة الـ Recombination
+
+275
+00:27:54,770 --> 00:28:00,490
+وهنا يعني الأصل
+
+276
+00:28:00,490 --> 00:28:06,810
+ماشي اللي بيسموه الـ Independent Assortment إذا
+
+277
+00:28:06,810 --> 00:28:13,890
+كان عندنا يعني حكيت يمكن أنا جملة انتبهت عليها
+
+278
+00:28:13,890 --> 00:28:21,370
+قضية إنه النتائج مندل على الثمان صفات اللي درسها
+
+279
+00:28:22,010 --> 00:28:26,770
+الورد من فوق، لون الحب خضر أو صفر أو مجعلك أو
+
+280
+00:28:26,770 --> 00:28:34,810
+مستديرة الصفات هذه كانت بالصدفة هيك بالنسبة لكل
+
+281
+00:28:34,810 --> 00:28:42,330
+دراساته أنه كل صفة على كروموزوم مختلف فالأصل أن كل
+
+282
+00:28:42,330 --> 00:28:53,500
+كروموزوم يعني يتم انفصاله بشكلمنفصل تماماً معاه عن
+
+283
+00:28:53,500 --> 00:29:03,180
+الآخر بس أحياناً يعني المبدأ اللي أول شيء بنفكر
+
+284
+00:29:03,180 --> 00:29:10,880
+فيه قضية Independent Assortment يعني إذا أنا عندي
+
+285
+00:29:10,880 --> 00:29:17,580
+صفة وراثية A capital و small a على locus one على
+
+286
+00:29:17,580 --> 00:29:24,230
+كرموزوم معينوفيه عندي صفة B على كرموزوم ثاني
+
+287
+00:29:24,230 --> 00:29:32,830
+وبمثلها capital B small b الأصل بما أن هدولا
+
+288
+00:29:32,830 --> 00:29:40,910
+الصفتين على كرموزمين مختلفين الأصل أنه لما يصير
+
+289
+00:29:40,910 --> 00:29:53,600
+assortment يعني انفصال بين الكرموزوماتالأصل أنه
+
+290
+00:29:53,600 --> 00:30:05,100
+يعني إذا مثلًا يكون مثلًا عندنا الـ Individual هذا
+
+291
+00:30:05,100 --> 00:30:11,940
+إذا بنشوف كيف هذا أخذ الـ Capital A الـ G
+
+292
+00:30:11,940 --> 00:30:17,360
+الـChromosome اللي فيه عنده Capital A وأخذالـ
+
+293
+00:30:17,360 --> 00:30:27,860
+Chromosome اللي عنده كابيتل B ماشي الآن
+
+294
+00:30:27,860 --> 00:30:35,660
+احنا هنا اللي بنحكي عنه في ظاهرة الـ Meiosis يعني
+
+295
+00:30:35,660 --> 00:30:40,440
+عند تحدوط الإنقسام المنصي يعني هدولة الثنتين اللي
+
+296
+00:30:40,440 --> 00:30:48,770
+بنحكي عنهم هنا هم الـ Ova والـ Spareفالـ Ova أو
+
+297
+00:30:48,770 --> 00:30:55,310
+الـ Sperm هنا الـ Sperm هذا الحيوان المنوي هذا أخذ
+
+298
+00:30:55,310 --> 00:31:02,110
+الـ Chromosome الـ Capital A والـ Capital B مثلا
+
+299
+00:31:02,110 --> 00:31:07,590
+الاحتمال
+
+300
+00:31:07,590 --> 00:31:13,470
+الثاني أنههذه المجالات كلها مستحيلة لأن كل واحد
+
+301
+00:31:13,470 --> 00:31:18,730
+عندما تقوم بالانفصال بينهم ليس كل الانفصالات
+
+302
+00:31:18,730 --> 00:31:20,550
+تماماً مثل بعض
+
+303
+00:31:25,050 --> 00:31:30,650
+اللي فيها capital A أو نسميها من الأب كمصدر أصلي
+
+304
+00:31:30,650 --> 00:31:36,150
+بنتج عنها أنه
+
+305
+00:31:36,150 --> 00:31:42,050
+في الـSperm ثاني الـA أخد تبع الأب والـB أخد تبع
+
+306
+00:31:42,050 --> 00:31:50,170
+الأم، ماشي؟ فهنا الصورة هذه، ماشي؟ بتبين الأصل في
+
+307
+00:31:50,170 --> 00:31:55,240
+الـIndependent Assortmentيعني الأصل لو الأمور
+
+308
+00:31:55,240 --> 00:32:04,320
+تمامًا يعني أخدناها هنا على صفتين ورافقتين على
+
+309
+00:32:04,320 --> 00:32:10,120
+كرموزمين مختلفين الأصل أنه ما في علاقة بين هذه
+
+310
+00:32:10,120 --> 00:32:17,990
+والثانية، ماشي؟الأمر ممكن يتعقد أكثر من هيك أنه
+
+311
+00:32:17,990 --> 00:32:24,250
+أحيانًا لما أدرس مثلًا صفتين، واحدة هنا A والافترض
+
+312
+00:32:24,250 --> 00:32:33,810
+بالطرف الثاني C من تحت الـA والـC مع بعض وSmall A
+
+313
+00:32:33,810 --> 00:32:39,070
+وSmall C مع بعض، هيك الأصل بلاقي أنه مع
+
+314
+00:32:39,070 --> 00:32:42,490
+الـRecombination وقضية الـ
+
+315
+00:32:45,920 --> 00:32:53,540
+الـ Recombination هذه كظاهرة ممكن تجعلنا أنه يعني
+
+316
+00:32:53,540 --> 00:32:59,300
+هنا صحيح الجامعات
+
+317
+00:32:59,300 --> 00:33:03,740
+هنا في Capital A وهنا Capital B وهنا Small A
+
+318
+00:33:03,740 --> 00:33:09,040
+وSmall B بس هذه طلعت Capital A وSmall B وهذه Small
+
+319
+00:33:09,040 --> 00:33:19,330
+A وCapital Bإنه بالأخير ممكن شو اسمه الـ الـ الـ
+
+320
+00:33:19,330 --> 00:33:24,590
+هنا الـ combination أو الـ recombination طلع بشكل
+
+321
+00:33:24,590 --> 00:33:33,450
+مختلف وبكون هنا شو اسمه؟ بكون هنا بطريقة مختلفة
+
+322
+00:33:33,450 --> 00:33:41,150
+ثانية ماشي ال .. ال ..الـ Recombination يعني هي
+
+323
+00:33:41,150 --> 00:33:45,610
+ظاهرة بتحدث بيكون فيها خلال الـ Cell Division
+
+324
+00:33:45,610 --> 00:33:52,510
+ويروح ويجي وكل مرة بتنقسم الخلايا اللفة الخيط أو
+
+325
+00:33:52,510 --> 00:33:56,230
+لفة الحبل اللي أنا مطلوب في الـ Chromosome أفصله
+
+326
+00:33:56,230 --> 00:34:06,930
+بشكل نظيف وبشكل كاملبصير أنه بصير تبادل في قطع من
+
+327
+00:34:06,930 --> 00:34:13,550
+الـ DNA وبصير عن نتيجة الأمر هذا يعني أنه مش ظاهر
+
+328
+00:34:13,550 --> 00:34:19,970
+أو بيكون Independent Assortment فهي يعني الأصل في
+
+329
+00:34:19,970 --> 00:34:24,970
+الـ Assortment أنه يكون كامل، هيك بنفكر بس في
+
+330
+00:34:24,970 --> 00:34:30,130
+الحقيقة بيكون في عنا اسمها Recombination الأمر هذا
+
+331
+00:34:30,130 --> 00:34:37,940
+مربوط أو مهمفي قضايا إنه لما يكون عندي أكثر من صفة
+
+332
+00:34:37,940 --> 00:34:43,980
+مشتركة مع بعض يعني مثلاً اللي هي بيسموها Linked
+
+333
+00:34:43,980 --> 00:34:49,020
+disequilibrium وراح نتكلم عنها بعدين اللي هي إنه
+
+334
+00:34:49,020 --> 00:34:55,100
+إذا الصفة capital A بتيجي معاها إشي معين ظاهرة
+
+335
+00:34:55,100 --> 00:35:01,580
+الـRecombination بتكون مؤثرة وأوضح لما تكون القطع
+
+336
+00:35:01,580 --> 00:35:08,090
+من الـDNAالقطع أو الجينات على الكروموزوم بعاد عن
+
+337
+00:35:08,090 --> 00:35:15,130
+بعض وفي طول في الكروموزوم فإنه يكون قصير والجينات
+
+338
+00:35:15,130 --> 00:35:19,250
+جانب بعض في الغالب بتركب مع بعض وبتظلها مع بعض
+
+339
+00:35:19,250 --> 00:35:30,050
+فهنا الـ Crossing over بتلاقي يعني ممكن واحد
+
+340
+00:35:30,050 --> 00:35:38,470
+يدرسها خلّينا منيعني هذه النقاط تفاصيلها بالنسبة
+
+341
+00:35:38,470 --> 00:35:46,710
+للـ يعني الـ بالنسبة لتفاصيلها بدنا شيها كتير يعني
+
+342
+00:35:46,710 --> 00:35:49,750
+الـ
+
+343
+00:35:49,750 --> 00:35:54,450
+إذا افترضنا إن الـ
+
+344
+00:35:58,430 --> 00:36:04,470
+لما يكون فيه عندى أكثر من قليل A وB بالنسبة
+
+345
+00:36:04,470 --> 00:36:11,250
+للمشاكل اللي حصلت عندنا الـ Crossing over ماشي إذا
+
+346
+00:36:11,250 --> 00:36:16,170
+افترضنا إنه بالصدفة هنا Capital A و Capital B وهنا
+
+347
+00:36:16,170 --> 00:36:21,250
+Small a و Small b لما يصير عندى هيك الأصليات أو
+
+348
+00:36:21,250 --> 00:36:27,010
+هيك أنا لقيت إشي معين فيه مرات بلاقي إن الـ
+
+349
+00:36:27,010 --> 00:36:32,100
+Productسيكون small a مع capital B أو capital A مع
+
+350
+00:36:32,100 --> 00:36:42,260
+small b ممكن تكون موجودة يعني ماشي يعني يمكن لو
+
+351
+00:36:42,260 --> 00:36:47,360
+يعني
+
+352
+00:36:47,360 --> 00:36:56,700
+ممكن أحيانًا أكثر ظاهرة يعني أنا يعني بفكر فيها
+
+353
+00:36:58,000 --> 00:37:04,580
+بتحدث فيه هذه الشغلة بالنسبة مثلا لـ «HLA Antigen»
+
+354
+00:37:04,580 --> 00:37:09,320
+اللي هم تبعات المناعة اللي هو الـ «MHC Molecules»
+
+355
+00:37:09,320 --> 00:37:13,940
+في عندنا الـ «MHC Molecules» أو الـ «HLA Antigens»
+
+356
+00:37:13,940 --> 00:37:20,940
+الـ «Class I» والـ «Class II» ويكونيعني حتى لقينا
+
+357
+00:37:20,940 --> 00:37:26,260
+أنه لما نيجي نفحص الـ HLA Class I نفحص الـ A والـ
+
+358
+00:37:26,260 --> 00:37:33,100
+B وما نفحصش الـ C السبب أنه لقوا أن الـ B بيمشي
+
+359
+00:37:33,100 --> 00:37:38,640
+معاه C معين فبحيث أنه يعني في الغالب أن الواحد
+
+360
+00:37:38,640 --> 00:37:44,800
+يدرس ويتغلب أنه يدرس الـ HLA C مافيش داعي له يعني
+
+361
+00:37:44,800 --> 00:37:51,950
+سريرياً وعلمياًفي حالات معينة بسبب ظاهرة نسميها
+
+362
+00:37:51,950 --> 00:37:57,190
+«linkage disequilibrium» إنه إذا عندي كابيتال A
+
+363
+00:37:57,190 --> 00:38:03,610
+معين بيكون عندي الـ B كابيتال كمان وإذا الـ B الـ
+
+364
+00:38:03,610 --> 00:38:09,130
+A صغير بلاقي الأليل اللي معاه الـ B صغير مثلا،
+
+365
+00:38:09,130 --> 00:38:14,110
+نفترض ذلك فهذه يعني قضايا
+
+366
+00:38:14,950 --> 00:38:23,230
+أحيانًا زي ظاهرة الـ linkage disequilibrium بتكون
+
+367
+00:38:23,230 --> 00:38:32,210
+نتيجتها إنه يعني راح تكون راح
+
+368
+00:38:32,210 --> 00:38:39,750
+تكون نتيجتها إنه يعني في مجال إنه يتغيروا بحيث إنه
+
+369
+00:38:39,750 --> 00:38:44,310
+كل ما كانوا الجينات
+
+370
+00:38:44,600 --> 00:38:50,900
+مواقعهم قريبة مع بعض راح يكونوا بيمشوا مع بعض وكل
+
+371
+00:38:50,900 --> 00:38:54,880
+ما كانوا مجال إنه يكونوا بعاد عن بعض راح تكون
+
+372
+00:38:54,880 --> 00:38:58,480
+الاحتمالية
+
+373
+00:38:58,480 --> 00:39:02,720
+الـ Recombination ويكون إنه فيه اختلافات أكبر
+
+374
+00:39:02,720 --> 00:39:09,880
+بكثير، ماشي؟ هنا حاطين يعني تقييم للي حكينا
+
+375
+00:39:09,880 --> 00:39:15,530
+الـStrong linkage disequilibriumوالمثال اللي حطيه
+
+376
+00:39:15,530 --> 00:39:21,290
+لكم إياه «ظاهرة الريتينايتس بيجمنتوزا» نفس الـ
+
+377
+00:39:21,290 --> 00:39:26,930
+«جين» المسؤول عنه شكله فيه صعوبة أننا نفحصه أو
+
+378
+00:39:26,930 --> 00:39:31,990
+إحنا مش فاهمين شو دوره وشو هو ولا كده بس اللي
+
+379
+00:39:31,990 --> 00:39:39,270
+بيصير أنه ندرس عن طريق اللي هو بيسموه «marker
+
+380
+00:39:39,270 --> 00:39:46,180
+locus 2»يعني أنه
+
+381
+00:39:46,180 --> 00:39:52,380
+أحيانًا يعني إذا تخيلنا هنا الـ «ريتينايتس
+
+382
+00:39:52,380 --> 00:39:59,780
+بيجمينتوزا» الجين اللي هو الـD هذا فهذا الإنسان
+
+383
+00:39:59,780 --> 00:40:04,940
+هنا هي Female مصابة وعندها الـD Capital لأنه شكله
+
+384
+00:40:04,940 --> 00:40:11,490
+اتزامل dominant، ماشي؟والجين الثاني أو النسخة
+
+385
+00:40:11,490 --> 00:40:16,470
+الثانية طبيعية اللي هي Normal Small Capital تزوجت
+
+386
+00:40:16,470 --> 00:40:23,690
+شخص طبيعي فالآن هاي
+
+387
+00:40:23,690 --> 00:40:29,810
+الجين اللي هو مسبب للمرض ماشي أنا فيه صعوب أني
+
+388
+00:40:29,810 --> 00:40:37,170
+أدرسه فيه لسبب ما مشكلة أني أبحث عليه فإذا
+
+389
+00:40:37,170 --> 00:40:37,790
+لقيت
+
+390
+00:40:40,530 --> 00:40:49,250
+Two markers يعني جينات ثانية أنا وجدت المكافئة لها
+
+391
+00:40:49,250 --> 00:40:53,650
+بحيث أني بقدر أعلم عليها بقدر أعمل زي ما حكينا
+
+392
+00:40:53,650 --> 00:40:58,050
+fluorescence immunofluorescence
+
+393
+00:40:58,050 --> 00:41:02,730
+in-cyto-hybridization اللي هي الـFish مثلا على إنه
+
+394
+00:41:02,730 --> 00:41:06,950
+علاقة موجودة أو لا مش موجودة النسخة اللي أنا بدي
+
+395
+00:41:06,950 --> 00:41:16,990
+إياهافالفكرة أنه في حالة هذا الجين المسبب للمرض
+
+396
+00:41:16,990 --> 00:41:24,070
+هنا إذا عندي Two Markers بحب أستخدمهم الأحسن ليه
+
+397
+00:41:24,070 --> 00:41:30,170
+أنه أستخدم الـ Marker اللي هو الـ B لأن هذا قريب
+
+398
+00:41:30,170 --> 00:41:36,380
+لما يكون قريب إذا كانت Capital B وشفتهامعناته أه
+
+399
+00:41:36,380 --> 00:41:42,160
+والله في الغالب capital D وU وفيه احتمالية أن ..
+
+400
+00:41:42,160 --> 00:41:47,940
+يعني أن نكون ماشيين مع بعض الـ capital A هنا
+
+401
+00:41:47,940 --> 00:41:54,640
+البعيد كـ marker مش كويس السبب أنه مش دائما بمشي
+
+402
+00:41:54,640 --> 00:41:59,220
+معاه هذا يعني حتى في one generation افرض هذول الـ
+
+403
+00:41:59,220 --> 00:42:06,240
+Dodge خلفوا ثمانين وجيت أنا درستالـ Capital D
+
+404
+00:42:06,240 --> 00:42:09,680
+دائماً
+
+405
+00:42:09,680 --> 00:42:16,120
+بيجي معاها Capital B الأصل هنا الـ Capital D أجت
+
+406
+00:42:16,120 --> 00:42:21,280
+معاها Small B، ماشي؟ فهنا صار Recombination بين
+
+407
+00:42:21,280 --> 00:42:26,400
+هذا وهذا، ماشي؟ وهي الـ Capital D أجت معاها
+
+408
+00:42:26,400 --> 00:42:33,160
+Capital B، فهنا من اثنينمن ثلاث مصابين عندهم الـ
+
+409
+00:42:33,160 --> 00:42:40,900
+Capital D ماشي أثنين كان عندهم Capital B وواحد كان
+
+410
+00:42:40,900 --> 00:42:46,960
+Small B فمن ثلاث، أثنين طلعوا الـ Positive مع
+
+411
+00:42:46,960 --> 00:42:53,420
+الشكل المطلوب بينما المصابين، الأسف، الطبيعيين
+
+412
+00:42:53,420 --> 00:43:00,140
+اللي هم الخمس الثانيين، ماشي اللي عندهم Small D،
+
+413
+00:43:00,140 --> 00:43:11,520
+ماشيراح نلاقي إنه هاي «أ» متوقع الأصلي هنا «أ» هنا
+
+414
+00:43:11,520 --> 00:43:17,500
+«أ» هنا «أ» هنا «أ» اللي راح يكون نتيجة الأمر هذا
+
+415
+00:43:17,500 --> 00:43:33,550
+إنه بالنسبة لـ «D» مع الـ «D» ماشيالـ الـ الـ كان
+
+416
+00:43:33,550 --> 00:43:39,850
+الأصل capital A تكون موجودة بس أثنين من ثلاثة كانت
+
+417
+00:43:39,850 --> 00:43:46,550
+موجودة بينما الـ capital A موجودة في غالبية اللي
+
+418
+00:43:46,550 --> 00:43:50,890
+ماعندهم مش الـ disease فاللي بنقوله هنا يعني الـ
+
+419
+00:43:50,890 --> 00:44:00,460
+conclusion أنه الـ الـ marker B ماشيأحسن من الـ
+
+420
+00:44:00,460 --> 00:44:09,820
+Marker A لتشخيص هذا الجين المُصاب، ماشي؟ والظاهرة
+
+421
+00:44:09,820 --> 00:44:15,540
+بنسميها Linkage Dysequilibrium يعني إنه شو
+
+422
+00:44:15,540 --> 00:44:21,020
+احتمالية الـ Two copies أو Two alleles من الـ Same
+
+423
+00:44:21,020 --> 00:44:27,000
+gene يجي دايماً مع بعض، ماشي؟ والأمر مربوط يعني
+
+424
+00:44:27,000 --> 00:44:33,790
+إنه أحياناًحتى لو أنا يعني فاهم أنه متوقع أنه فيه
+
+425
+00:44:33,790 --> 00:44:41,150
+Mendelian disease وفيه mutation معينة نفس الـ
+
+426
+00:44:41,150 --> 00:44:45,050
+mutation اللي مسبب للمرض أنا أحيانًا ما بستطيع
+
+427
+00:44:45,050 --> 00:44:51,410
+أحددها، ما بكون قادر أعرفها بينما إشي قريب منه
+
+428
+00:44:51,410 --> 00:44:56,290
+مربوط معاه دائمًا مافيش الـ recombination between
+
+429
+00:44:56,290 --> 00:45:03,260
+themممكن أستفيد منه في قضية التشخيص
+
+430
+00:45:03,260 --> 00:45:11,560
+وبالتالي أقدر أعرف يعني مثال على ذلك الـ HLA
+
+431
+00:45:11,560 --> 00:45:17,320
+-antigen typing بنسوي الـ typing للـ A والـ B وفي
+
+432
+00:45:17,320 --> 00:45:25,660
+الـ HLA-C الـ C لأنه إذا مثلا الـ B كانت بشكل معين
+
+433
+00:45:26,050 --> 00:45:30,750
+الـ C بتكون بشكل محدد كمان معاها يعني فبالتالي
+
+434
+00:45:30,750 --> 00:45:35,810
+لاقوا إنه مافي فايدة بإنه أنا أبحث على الـ C السبب
+
+435
+00:45:35,810 --> 00:45:40,130
+إنه فيه linkage disequilibrium الـ A و الـ B بعد
+
+436
+00:45:40,130 --> 00:45:44,850
+عن بعض فبالتالي في احتمالية كبيرة إذا بلاقي إشي
+
+437
+00:45:44,850 --> 00:45:52,030
+معينالـ A والـ B ما بقدر أحدد شو هو مش قادر أعرف
+
+438
+00:45:52,030 --> 00:45:57,370
+شو هو أو ما بعرف مافيش يعني الترابط بينهم الأتنين
+
+439
+00:45:57,370 --> 00:46:02,770
+فهي
+
+440
+00:46:02,770 --> 00:46:09,650
+نتيجة قضية الـ Recombination أنه أنا عندي
+
+441
+00:46:09,650 --> 00:46:12,970
+Recombination في أسئلة
+
+442
+00:46:17,450 --> 00:46:25,170
+الـ Recombination يعني بدنا .. يعني أنت .. يعني هي
+
+443
+00:46:25,170 --> 00:46:33,470
+ظاهرة يعني أحيانًا لما نيجي ندرس ال population أو
+
+444
+00:46:33,470 --> 00:46:41,490
+البشر كيف أو كده كيف بتم توريثها، كيف بكون ال ..
+
+445
+00:46:41,490 --> 00:46:48,590
+يعنيانتقالها من شخص لشخص وكيف بيكون مجموعة الصفات
+
+446
+00:46:48,590 --> 00:46:55,050
+بتيجي مع بعض وهي أحيانًا يعني من الظواهر اللي أحنا
+
+447
+00:46:55,050 --> 00:47:01,190
+بنحكي عنه مرات اللي هي انه Polygenetic Disorders
+
+448
+00:47:01,190 --> 00:47:09,690
+أو Conditions أكثر بكثير بتكون أنه الـ … بتكون أنه
+
+449
+00:47:09,690 --> 00:47:16,090
+الـ Recombinationحدث أو ممكن يحدث بس كل ما كانوا
+
+450
+00:47:16,090 --> 00:47:20,150
+القطعتين بعيد عن بعض بيصير الـ Recombination أكثر
+
+451
+00:47:20,150 --> 00:47:25,570
+كل ما كانوا قريبات على بعض بيكون الإمكانية إنه
+
+452
+00:47:25,570 --> 00:47:30,630
+يمشوا اثنين مع بعض أكثر فهذه يعني ظاهرة بتحدث،
+
+453
+00:47:30,630 --> 00:47:35,270
+ظاهرة يعني أحياناً بتكون مهم إن الواحد يتذكرها
+
+454
+00:47:35,270 --> 00:47:42,200
+ويعني أحياناً بتكون له أهمية سريريةمن ناحية كيف
+
+455
+00:47:42,200 --> 00:47:50,360
+نتعامل مع الموضوع هذا فيه أسئلة نفس
+
+456
+00:47:50,360 --> 00:47:57,660
+الفكرة كل ما أبعدوا الجينات عن بعض على الـ DNA على
+
+457
+00:47:57,660 --> 00:48:02,140
+الـ Chromosome احتمال إن يكونوا الـ Alleles
+
+458
+00:48:02,140 --> 00:48:07,720
+مختلفين على البعض بتكون النسبة أكبر فتفاصيل الأمور
+
+459
+00:48:07,720 --> 00:48:16,650
+بتديشيها يعنيtoo much details ماشي الـ load score
+
+460
+00:48:16,650 --> 00:48:23,790
+اللي هو logarithmic نسيت اختصار يعني اللي هو معامل
+
+461
+00:48:23,790 --> 00:48:27,270
+احتمالية
+
+462
+00:48:27,270 --> 00:48:36,710
+انتقال الأليل مع بعض ماشي فهنا
+
+463
+00:48:36,710 --> 00:48:37,750
+three families
+
+464
+00:48:40,600 --> 00:48:48,580
+شو اسمه؟ تفاصيلها خلاص، بلا منها ماشي، تسألونيش
+
+465
+00:48:48,580 --> 00:48:55,500
+يعني بالنسبة ده بدنا ندخل بتفاصيل هنا يعني الـ
+
+466
+00:48:55,500 --> 00:49:00,980
+«take home message» الرسالة اللي بدنا إياها إنه
+
+467
+00:49:00,980 --> 00:49:09,310
+رياضياً أنا ممكن أعبر عن ارتباط قليل معينبأليل
+
+468
+00:49:09,310 --> 00:49:13,110
+آخر، والقصد في الموضوع اللي هي الظاهرة اللي هنا
+
+469
+00:49:13,110 --> 00:49:21,650
+اللي هي أنه أنا ببدأ يعني بالـChromosomes
+
+470
+00:49:21,650 --> 00:49:28,190
+وعليها الأليل في الـLocus مثلا A1 بشكل معين
+
+471
+00:49:28,190 --> 00:49:36,770
+وChromosome ثاني بكون بشكل آخر الـLocus 2 وفيه
+
+472
+00:49:36,770 --> 00:49:43,040
+Capital B وSmall bبالأخير اللي موجود بعد مرور كذا
+
+473
+00:49:43,040 --> 00:49:49,080
+generation وبسبب الـRecombination الأمور راح تكون
+
+474
+00:49:49,080 --> 00:49:54,960
+أنه أي قطعة بتكون الأصول من كل الأصول بتلاقيها
+
+475
+00:49:54,960 --> 00:50:01,120
+موجودة يعني اللي هي كمان هنا اللي هي أنه بيصير هذا
+
+476
+00:50:01,120 --> 00:50:06,220
+الإنسان الـthird generationالـ Chromosome الأول،
+
+477
+00:50:06,220 --> 00:50:09,840
+مع أنه بالأول الواحد هيك بيحب أنه يفكر أنه الـ DNA
+
+478
+00:50:09,840 --> 00:50:18,880
+والـ Cell Division هيك يعني نظيف وكامل وبينفصل
+
+479
+00:50:18,880 --> 00:50:23,620
+بشكل تم إلا أنه الأمور أعقد من هيك وأنه بتصير
+
+480
+00:50:23,620 --> 00:50:28,180
+عملية الـ Recombination ونتيجتها اللي هي Linked
+
+481
+00:50:28,180 --> 00:50:35,820
+Disequilibrium يعني أنه الـ Lociأو المكان على الـ
+
+482
+00:50:35,820 --> 00:50:42,920
+DNA إذا كان قريب مع بعض هنا في الغالب هيمشوا مع
+
+483
+00:50:42,920 --> 00:50:51,640
+بعض بينما لما نكون بأد راح يصير الاختلاف إن هنا
+
+484
+00:50:51,640 --> 00:50:58,040
+مثلًا هاي كابيتل A كابيتل small a في الـ Locus 1
+
+485
+00:50:58,040 --> 00:51:05,880
+وهنا كابيتل B small b في الـ Locus 2النتيجة إذا
+
+486
+00:51:05,880 --> 00:51:13,920
+صار عندي عملية الـ Recombination ماشي هنا هذه
+
+487
+00:51:13,920 --> 00:51:21,540
+النسخة شبيهة بالأصلي بينما هذه جلبه فصار الـ
+
+488
+00:51:21,540 --> 00:51:26,820
+capital A مع small b و الـ small a مع الـ capital
+
+489
+00:51:26,820 --> 00:51:32,480
+B تصير عملية الـ Recombination ماشيتفاصيلها كيف كل
+
+490
+00:51:32,480 --> 00:51:39,260
+واحدة يعني شون
+
+491
+00:51:39,260 --> 00:51:41,420
+الـ non-recombinant و الـ recoisant و الـ
+
+492
+00:51:41,420 --> 00:51:46,220
+recombinant هدولة أثنتين زي بعض بس المهم أنه جلب
+
+493
+00:51:46,220 --> 00:51:51,340
+صارت عملية recombination هنا ماشي بس إذا كانوا
+
+494
+00:51:51,340 --> 00:51:56,810
+قريبين على بعضلا يوجد تجاربًا مرتبطًا، بيبقى كما
+
+495
+00:51:56,810 --> 00:52:03,410
+هو بيبقى .. يعني عندما ندرس باستخدام الـ two loci
+
+496
+00:52:03,410 --> 00:52:08,650
+هذولة بما أنهم قريبين على بعض احتمالية أنه يمشوا
+
+497
+00:52:08,650 --> 00:52:14,390
+مع بعض أكبر بكتير كل ما أبعده بيصير فيه احتمالية
+
+498
+00:52:14,390 --> 00:52:19,330
+أكبر أنه يصير عملية الـ recombination ماشي
+
+499
+00:52:21,210 --> 00:52:31,150
+يعني هنا حاطين أن أحيانًا القطع واللصق بالنسبة للـ
+
+500
+00:52:31,150 --> 00:52:38,610
+Recombination بنتج عنه أنه الكمية
+
+501
+00:52:38,610 --> 00:52:44,170
+أكبر، يعني عدد الخلايا اللي فيها دول أثنين مهشت مع
+
+502
+00:52:44,170 --> 00:52:44,710
+بعض
+
+503
+00:52:47,490 --> 00:52:52,630
+يعني إن السنتين الذولة ماشيت مع بعض أكثر مش في
+
+504
+00:52:52,630 --> 00:52:57,690
+مثلا كل الخلايا أو نص الخلايا أو كده يعني إن شاء
+
+505
+00:52:57,690 --> 00:53:04,210
+الله هذه الفكرة تكون واضحة وتأثيراتها في قضية إنه
+
+506
+00:53:04,210 --> 00:53:10,570
+أحيانًا أنا ماعندي الـ الـ الـ الـ issue محدد للـ
+
+507
+00:53:10,570 --> 00:53:17,150
+gene causing diseaseبكون عندي إشي لإشي قريب منه
+
+508
+00:53:17,150 --> 00:53:21,350
+فإذا عندي الإشي للقريب منه بهمني إنه يكون هذا
+
+509
+00:53:21,350 --> 00:53:26,030
+الإشي قريب جدا على طول ملزق فيه لأنه إذا كان على
+
+510
+00:53:26,030 --> 00:53:29,530
+طول ملزق فيه احتمالية إنه يكون بينهم Recombination
+
+511
+00:53:29,530 --> 00:53:37,610
+قليلة من كل مكان أبعد بيكون الأمور أصعب في أسئلة؟
+
+512
+00:53:43,700 --> 00:53:47,560
+كاريم بده يتكلم يا دكتور، مش عارف يبدو عنده سؤال
+
+513
+00:53:47,560 --> 00:53:54,940
+نعم، فضل حقيقة أنت كنت في سنة وصار هناك
+
+514
+00:53:54,940 --> 00:53:59,280
+combination بين الجنات تصبح فرصة أصعب إنه يمشوا
+
+515
+00:53:59,280 --> 00:54:07,720
+الجنات مع بعض وينتقلوا مع بعض؟ لما أنا أتكلم على،
+
+516
+00:54:07,720 --> 00:54:14,150
+أسا أنا بتكلم على two low sides، يعني مكانينعلى
+
+517
+00:54:14,150 --> 00:54:21,370
+الـ يعني مثلًا أنا بتكلم خاصية الـ ABO group مثلًا
+
+518
+00:54:21,370 --> 00:54:32,830
+مع الـ Rh group ماشي لفصيلة الدم بس إذا الـ ABO
+
+519
+00:54:32,830 --> 00:54:40,290
+Locus قريب Locus يعني محل ما هذا الـ gene موجود
+
+520
+00:54:40,290 --> 00:54:46,570
+الـ Rh قريب كثير عنشو راح يصير؟ بيصير مافي داعي
+
+521
+00:54:46,570 --> 00:54:51,570
+تفحص الـ RH فاهم عليك أيه؟ أو تفحص الـ Ebio
+
+522
+00:54:51,570 --> 00:54:57,950
+بيكفيني واحد لأنه ثاني بلزق فيه جاي معاه يعني كل
+
+523
+00:54:57,950 --> 00:55:04,730
+ما كانوا أبعد ماشي ال .. كل ما كانوا أبعد احتمالية
+
+524
+00:55:04,730 --> 00:55:09,350
+ان يصير الـ recombination أكبر يعني لو جيت في
+
+525
+00:55:09,350 --> 00:55:15,320
+generation معينة أنا عيلة معينة درست عليهاالـ ABO
+
+526
+00:55:15,320 --> 00:55:20,700
+و الـ Rh و روحت دورت وين ما كان الـ «جين» هذا ماشي
+
+527
+00:55:20,700 --> 00:55:26,480
+إذا قريبات كتير على بعض راح ألاقي إنه فيه ارتباط و
+
+528
+00:55:26,480 --> 00:55:34,480
+إنه بيصير هو يعني الـ «ماركر» اللي هو عنديا
+
+529
+00:55:34,480 --> 00:55:41,100
+أستخدمه كمان عشان أدرس هذه الظاهرة بيكون مفيد كتير
+
+530
+00:55:41,100 --> 00:55:47,740
+لأنه قريب كتيرومافيش Recombination وبنسميه فيه
+
+531
+00:55:47,740 --> 00:55:50,840
+Linked Disequilibrium هذه الكلمة اللي بدي إياها
+
+532
+00:55:50,840 --> 00:55:57,880
+اللي هي إنه في عندنا ارتباط بين الـ الـ الـ الـ
+
+533
+00:55:57,880 --> 00:56:03,380
+إذا الأليل هذا A Capital بيجي معاه مثلا الـ B
+
+534
+00:56:03,380 --> 00:56:07,380
+Capital أو بيجي معاه إشي محدد فأنا هيبقى أستفيد من
+
+535
+00:56:07,380 --> 00:56:09,440
+هذه الظاهرة، ماشي؟
+
+536
+00:56:14,880 --> 00:56:22,520
+يعني استخدام هذا المفهوم بروري أحيانًا سريرياً ليش
+
+537
+00:56:22,520 --> 00:56:29,940
+ندرس بشكل معين وأحيانًا أنه أنا ممكن تجينة عالية
+
+538
+00:56:29,940 --> 00:56:39,640
+عندها مرض مايكنش عنده الـ Marker الـ Exact للجين
+
+539
+00:56:39,640 --> 00:56:47,190
+المسبب للمرض فمضطر أنا أستخدمماركر لجين إشي قريب
+
+540
+00:56:47,190 --> 00:56:55,890
+منه إذا الإشي القريب منه هذا اللي استخدمته يعني ما
+
+541
+00:56:55,890 --> 00:56:59,550
+هي الفكرة أنه لما يكون عند عيلة عندها الحالة يعني
+
+542
+00:56:59,550 --> 00:57:03,730
+زي مثلا ما اتكلمنا على إن افترض الـ Retinitis
+
+543
+00:57:03,730 --> 00:57:10,870
+Pigmentosa بهذا الشكل ماشي أب و أم الأم صابة جابوا
+
+544
+00:57:10,870 --> 00:57:17,500
+ثمان أفرادثلاثة مصابين وخمسة مش مصابين هذه الحالة
+
+545
+00:57:17,500 --> 00:57:23,340
+المثالية اللي أنا بروح بدرس ودلقيت عيل زي هيك أنا
+
+546
+00:57:23,340 --> 00:57:28,240
+لما فرجتكم شوفتم تذكروا صورة العقل اللي إيديهم
+
+547
+00:57:28,240 --> 00:57:32,000
+عنده قلنا سمناه أقرب شيء له زي الـInfantile
+
+548
+00:57:32,000 --> 00:57:35,980
+Digital Fibromatosis اللي هي صورة الإدانة بشكل
+
+549
+00:57:35,980 --> 00:57:42,780
+معين فلما تجيني عقل زي هيكأنا في عندى إشكالية إنه
+
+550
+00:57:42,780 --> 00:57:49,100
+أنا ما بعرف مية بالمية الـGene و الـLocus اللي هو
+
+551
+00:57:49,100 --> 00:57:56,910
+مسبب للمرض أنا ما بعرفه بس ممكن أستفيدإذا فيه إشي
+
+552
+00:57:56,910 --> 00:58:01,650
+قريب جدا عليه كأنه أستخدمه كـ Marker بعدين مثلا
+
+553
+00:58:01,650 --> 00:58:11,950
+خلفه جابه شخص يعني صار يعني الإمرأة هذه حملت جابت
+
+554
+00:58:11,950 --> 00:58:16,430
+التاسع يسألوك هذا بدي يطلع مصاب ولا مش مصاب مثلا
+
+555
+00:58:16,430 --> 00:58:21,290
+بدك تدرس وتستفيد من ظاهرة الـ linkage
+
+556
+00:58:21,290 --> 00:58:25,590
+disequilibriumأتكون متأكد، الـ Marker اللي أنا
+
+557
+00:58:25,590 --> 00:58:31,550
+هستخدمه أنا مش متأكد إنه للـ Disease 100% إنما أنا
+
+558
+00:58:31,550 --> 00:58:34,610
+بتوقع إن هو عشان قريب من الـ Disease بقدر أستفيد
+
+559
+00:58:34,610 --> 00:58:44,950
+منه فضمن الدراسة فالـ في الحالة هذه بستخدم
+
+560
+00:58:44,950 --> 00:58:53,070
+الـ Marker وبكون يعني بدأ أكون منتبه إنهالـ Marker
+
+561
+00:58:53,070 --> 00:59:00,990
+اللي لاقيته قداش دقيق في أنه يكون قريب من الـ
+
+562
+00:59:00,990 --> 00:59:06,690
+Disease Gene حيث أنه يكون إذا Marker كويس بيكون
+
+563
+00:59:06,690 --> 00:59:13,050
+الـ Load تبعه ماشي اللي هو المعامل الإرتباط تبعه
+
+564
+00:59:13,050 --> 00:59:16,030
+Code-Theor فهذه النقطة اللي بدنا يحصل
+
+565
+00:59:19,460 --> 00:59:23,900
+دكتور في سؤال من Carmel بتقول إيش الفرق ما بين الـ
+
+566
+00:59:23,900 --> 00:59:29,740
+recombination و ال crossing over هم نفسهم هم نفسهم
+
+567
+00:59:29,740 --> 00:59:38,860
+ال crossing over يعني عملية حدوث انتقال من ال DNA
+
+568
+00:59:38,860 --> 00:59:47,380
+كقطعة من جهة إلى جهة أخرى ماشي النتيجة الأمر هذا
+
+569
+00:59:47,380 --> 00:59:55,940
+أنه هيصير عنديrecombination إنه يعني هو نتيجة
+
+570
+00:59:55,940 --> 01:00:05,100
+نتيجة الحدث هذا يعني المتشابهات يعني ماشي ال
+
+571
+01:00:05,100 --> 01:00:11,480
+crossing over هي الظاهرة اللي بتسببلي القضية
+
+572
+01:00:11,480 --> 01:00:14,820
+بتسببلي
+
+573
+01:00:14,820 --> 01:00:23,420
+قضية ال recombination ماشيالـ يعني تتذكروا لما
+
+574
+01:00:23,420 --> 01:00:28,500
+حكينا مثلا حتى عن زي الـ Down Syndrome الـ
+
+575
+01:00:28,500 --> 01:00:37,100
+Crossing Over ماشي بقطع و لثق في الـ DNA من قطع مش
+
+576
+01:00:37,100 --> 01:00:45,980
+المفروض تكون مع بعض، ماشي؟ فالقطع واللثق أحيانًا
+
+577
+01:00:47,660 --> 01:00:53,660
+بيكونش متساوي أو القطع واللثق راح ينتج عنه إنه فيه
+
+578
+01:00:53,660 --> 01:00:58,660
+قطعة كبيرة زيادة وفيه قطعة صغيرة فهنا شو صار عندي؟
+
+579
+01:00:58,660 --> 01:01:04,580
+هنا صار عندي Crossing Over بس الـ Recombination هي
+
+580
+01:01:04,580 --> 01:01:08,980
+المحصلة النهائية لما يكونوا Balanced لما يكونوا
+
+581
+01:01:08,980 --> 01:01:16,080
+متوازنين لما تكون يعنيبالأخير يقدر ينقر الصفات
+
+582
+01:01:16,080 --> 01:01:21,740
+الوراثية ويولد جنين ويولد طفل ويولد يوجد إنسان
+
+583
+01:01:21,740 --> 01:01:27,800
+جديد فالـ Recombination يعني آليتها الـ Crossing
+
+584
+01:01:27,800 --> 01:01:34,460
+Over بس الـ Crossing Over ممكن يسبب مشاكل غير الـ
+
+585
+01:01:34,460 --> 01:01:40,840
+Recombination أو يعني ظواهر أشد وغير يعنيأسأل،
+
+586
+01:01:40,840 --> 01:01:45,720
+يعني أتمنى يكون الأمر واضح أيوة كريم، إذا عنده
+
+587
+01:01:45,720 --> 01:01:57,080
+سؤال بالنسبة
+
+588
+01:01:57,080 --> 01:02:09,500
+لما ندرس دواهر زي هيك يعني حقيقة من الاشياء
+
+589
+01:02:09,830 --> 01:02:17,770
+اللي عم بيستفيدوا منها هي قضية الـGenome-wide
+
+590
+01:02:17,770 --> 01:02:27,570
+Association Study الـGWAS لما
+
+591
+01:02:27,570 --> 01:02:30,910
+نكون
+
+592
+01:02:30,910 --> 01:02:37,910
+عندنا إمكانية نعمل Sequencing لكل الـDNA لكل 9
+
+593
+01:02:37,910 --> 01:02:45,100
+ملياراتنكليوتايد مرة واحدة وأجي أنا أعملهم، ماشي
+
+594
+01:02:45,100 --> 01:02:56,020
+لما يكون حاجة زي هيك بإمكاني
+
+595
+01:02:56,020 --> 01:03:06,570
+معاها أدرس و أكون يعنيمحدد إذا كان عندي Markers
+
+596
+01:03:06,570 --> 01:03:15,050
+كويسة لبعض الـ Diseases بسير أشوف احتمالية حدوث
+
+597
+01:03:15,050 --> 01:03:22,750
+أمراض معينة وهذه عادة، يعني هذه عبارة عن خدمة
+
+598
+01:03:22,750 --> 01:03:27,870
+متوفرة في الدول المتقدمة يعني مثلًا في أمريكا
+
+599
+01:03:27,870 --> 01:03:32,510
+تعطيهم عينة دم تبعتك، ماشي
+
+600
+01:03:35,540 --> 01:03:41,320
+اللي بيعملوا genome-wide association study اللي
+
+601
+01:03:41,320 --> 01:03:46,200
+اسمه الـ GWAS النتيجة بتاعتها بيسموها «ايمان هاتن
+
+602
+01:03:46,200 --> 01:03:54,300
+بلوت» بيادا الشكل الفكرة أنه يعني
+
+603
+01:03:54,300 --> 01:04:01,530
+نتيجة تبع الأمر هذا أنهسواءً عندي الـ Marker للـ
+
+604
+01:04:01,530 --> 01:04:06,930
+Gene نفسه المصاد والطبيعي وبقدر أفرق بينهم أو
+
+605
+01:04:06,930 --> 01:04:14,530
+Marker لإيش قريب منه بحيث أنه يكون في ارتباط مع
+
+606
+01:04:14,530 --> 01:04:24,930
+الـ Disease معينة بقدر أعطي الإنسان تقرير بحيث أنه
+
+607
+01:04:24,930 --> 01:04:34,160
+يعنيإذا الواحد بيشوف الأشياء اللي موجودة، ماشي
+
+608
+01:04:34,160 --> 01:04:41,340
+مثلًا SF1 اللي هو Cystic Fibrosis Inheritance
+
+609
+01:04:41,340 --> 01:04:50,840
+مثلًا Adams، فيه Adams 13 تبع مثلًا الـTTP اللي هو
+
+610
+01:04:50,840 --> 01:04:56,140
+«Thrombotic Thrombocytopenic Fever» مش عارف كده
+
+611
+01:04:56,660 --> 01:05:04,900
+فالفكرة أنه من الاستفادات لقضية الـ Recombination
+
+612
+01:05:04,900 --> 01:05:11,340
+ومن الاستفادات في بالذات اللي بيسموه الـ
+
+613
+01:05:11,340 --> 01:05:15,560
+Individualized Medicine يعني إن أنا أحاول أدرس
+
+614
+01:05:15,560 --> 01:05:21,010
+التركيب الجيني تبع الإنسان اللي أماميبحيث أفهم هو
+
+615
+01:05:21,010 --> 01:05:26,930
+محتمل أكثر يصيبوا إيش وما يصيبوش إيش بهذا الشكل
+
+616
+01:05:26,930 --> 01:05:34,270
+بأستخدم كلمة بدي إياكم تتذكروها اسمها «Genome-wide
+
+617
+01:05:34,270 --> 01:05:43,890
+Association Studies» GWAAS هذه مبدأ تقني مبدأ
+
+618
+01:05:43,890 --> 01:05:57,880
+مختبري بيعمل بطريقة معينةبدور على هنا الـ Single
+
+619
+01:05:57,880 --> 01:06:04,120
+Nucleotide Polymorphism Alleles على إشي معين
+
+620
+01:06:04,120 --> 01:06:12,760
+بالأخر يعني شفت أنا تقارير الـ Report اللي طلعوا
+
+621
+01:06:12,760 --> 01:06:20,160
+زي ما كنا في مرة من قبل يعني شبيه بأنه يعطيكوالله
+
+622
+01:06:20,160 --> 01:06:29,620
+انت 60% أو 50% قوقازي 40% أسياوي، 6% أفريقي مش
+
+623
+01:06:29,620 --> 01:06:35,460
+عارف من وين انت جيت يعني زي هذه الظاهرة بعطيني
+
+624
+01:06:35,460 --> 01:06:43,940
+كمان تقرير على إنه عندك احتمالية مثلًا 20% يكون
+
+625
+01:06:43,940 --> 01:06:46,620
+معاك سكري عندك احتمالية 10%
+
+626
+01:06:49,300 --> 01:06:54,940
+يكون معاك مثلاً ضغط عندك نسبة واحد بالمائة يكون
+
+627
+01:06:54,940 --> 01:07:00,280
+عندك Alzheimer عندك واحد بالمائة نسبة كذا يعني
+
+628
+01:07:00,280 --> 01:07:05,320
+بعطيك الاحتماليات
+
+629
+01:07:05,320 --> 01:07:08,940
+وبكون
+
+630
+01:07:08,940 --> 01:07:17,660
+يعني هذه بدك تدخل بتفاصيل دقيقة كيف انعملت وشو
+
+631
+01:07:17,660 --> 01:07:22,080
+اللي انعملزي ما انتوا شايفين هنا يعني هنا اللي هما
+
+632
+01:07:22,080 --> 01:07:27,480
+الـ 22 كروميزون والـ
+
+633
+01:07:27,480 --> 01:07:33,420
+X والـ Y المفروض يكونوا كمان موجودين وبيعطيك تقرير
+
+634
+01:07:33,420 --> 01:07:40,540
+انت شو متوقع الأمراض اللي انت تكون تعاني منها أو
+
+635
+01:07:40,540 --> 01:07:45,720
+إلك احتمالية يكون عندك فيها وشكله الـ Report
+
+636
+01:07:45,720 --> 01:07:55,640
+بيعطيك فكرةإنه كام قرب هذا الـ Crow أليل بهذا
+
+637
+01:07:55,640 --> 01:08:01,940
+الشكل مع الـ Disease بيعطيك نسبة احتمالية إنك يكون
+
+638
+01:08:01,940 --> 01:08:06,240
+عندك هذا الـ Disease يعني و أنا 300 مرة أكثر من
+
+639
+01:08:06,240 --> 01:08:13,640
+الإنسان الطبيعي أو يعني مضاعف و شكل لغريثمي و أنا
+
+640
+01:08:13,640 --> 01:08:22,940
+القراءة فـيعني أنه الآن الفكرة أنه باستخدام الـ
+
+641
+01:08:22,940 --> 01:08:25,920
+Linkage Disequilibrium أو الـ Recombination
+
+642
+01:08:25,920 --> 01:08:31,740
+Studying وإذا عندي آليات
+
+643
+01:08:31,740 --> 01:08:39,020
+أو تقنية أو آلات تقدر تعمل Whole Genome Sequencing
+
+644
+01:08:39,020 --> 01:08:49,230
+كامل لكل الـ DNA بإمكاني أني بالأخير أطلعاحتمالات
+
+645
+01:08:49,230 --> 01:08:55,030
+logarithmية أو احتمال الإصابة
+
+646
+01:08:55,030 --> 01:08:58,910
+كاريم
+
+647
+01:08:58,910 --> 01:09:03,270
+بيسأل، بقول، يعني بناء على شو بيعطي احتمالية حدوث
+
+648
+01:09:03,270 --> 01:09:06,550
+المرض يعني افسدوا احتمالية حدوث المرض، ايش بيجيس؟
+
+649
+01:09:06,550 --> 01:09:18,580
+لأ، الامر بتكلم على انه انا عندي أداءعندى tool
+
+650
+01:09:18,580 --> 01:09:24,540
+بستفيد منها هاي في دول اللي فاضين وعندهم إمكانات
+
+651
+01:09:24,540 --> 01:09:33,320
+يعملوا أشياء زي هيك بدك أنت يعني بشكل مسبق بشكل
+
+652
+01:09:33,320 --> 01:09:40,960
+يعني استشراف للمستقبل لشوه احتمالية أنه إنسان يكون
+
+653
+01:09:40,960 --> 01:09:44,280
+عنده الحالة اللي فلانية فاهم عليك كده؟
+
+654
+01:09:46,900 --> 01:09:56,740
+فالموضوع أنه أنت عندك الـ Tool أنك تقدر تفحص كل
+
+655
+01:09:56,740 --> 01:10:02,280
+الجينات أو كل الـ DNA وتقراها كلها بضاربة واحدة،
+
+656
+01:10:02,280 --> 01:10:08,280
+ماشي؟ يعني زي تقول، إذا الواحد بتذكر أيام زمان
+
+657
+01:10:08,280 --> 01:10:13,460
+الكمبيوترات كانت بطيقةالان الكمبيوترات سريعة وقوية
+
+658
+01:10:13,460 --> 01:10:18,040
+جداً جداً جداً فانت عندك زي هيك يعني زي ما تقول
+
+659
+01:10:18,040 --> 01:10:26,400
+كنت زمان اتدور على نرجع على قضية القصائد والكلمات
+
+660
+01:10:26,400 --> 01:10:37,200
+والأحرف كنت بدك مثلا لو عندك مكتب ورقيهوأقولك بيت
+
+661
+01:10:37,200 --> 01:10:44,640
+الشعر الفلاني مين جابه؟ مين عمله؟ مين قاله؟ بتتغلب
+
+662
+01:10:44,640 --> 01:10:50,080
+جداً ومليارات يعني آلاف الكتب وكيف بدك تدور عليه
+
+663
+01:10:50,080 --> 01:10:54,720
+فينما حسة لما يكون عندك زي Google Search بتحط
+
+664
+01:10:54,720 --> 01:10:59,780
+الكلمتين تلاتي بتطلعلك خيارات خلال seconds أو
+
+665
+01:10:59,780 --> 01:11:04,080
+milliseconds أو nanosecondsخلال فترة قصيرة جدا
+
+666
+01:11:04,080 --> 01:11:09,620
+بتجيبك احتمالية بيفهم عليك من وين على شو أنت بتدور
+
+667
+01:11:09,620 --> 01:11:16,260
+يعني فالفكرة شبيهة في هذه الحدث يعني أنه أنا الـ
+
+668
+01:11:16,260 --> 01:11:22,740
+DNA عبارة عن كلمات وأحرف وكذا الآن أحياناً الكلمة
+
+669
+01:11:22,740 --> 01:11:26,880
+هذه في بيت الشعر هذا في البروتين هذا في القصيدة
+
+670
+01:11:26,880 --> 01:11:31,950
+الفلانيةأحيانًا مش هو نفسه المسبب للمرض 100% أنا
+
+671
+01:11:31,950 --> 01:11:37,270
+قد لا أكون متأكد من هذا الموضوع بس بيظل إنه إذا
+
+672
+01:11:37,270 --> 01:11:41,270
+بقدر أعمل Search لكل إنسان أو للإنسان اللي بيجي
+
+673
+01:11:41,270 --> 01:11:49,450
+عندى، ماشي، على المستشفى، بكون، شو اسمه؟ بكون عندى
+
+674
+01:11:49,450 --> 01:11:53,590
+آليات أحسن إني أدرس الموضوع هذا، ماشي؟
+
+675
+01:11:57,130 --> 01:12:01,730
+الموضوع مش إنه أنا بكون واثق إن هذا الإنسان راح
+
+676
+01:12:01,730 --> 01:12:05,590
+يصيب المرض الإفلاني ما بقدر أحكي الكلام هذا الكلام
+
+677
+01:12:05,590 --> 01:12:12,310
+يعني الاستنتاج اللي راح يجيه إنه فيه احتمالية بقدر
+
+678
+01:12:12,310 --> 01:12:18,270
+أعطيها نسب أو حسب قربها وحسب ثقة بالنسبة للموضوع
+
+679
+01:12:18,270 --> 01:12:22,630
+هذا بعطيها نسب يا إما عالي كتير يا إما واطي أو أقل
+
+680
+01:12:22,630 --> 01:12:30,270
+أو كدهماشي بالنسبة
+
+681
+01:12:30,270 --> 01:12:36,710
+لـ .. يعني أحياناً
+
+682
+01:12:36,710 --> 01:12:42,750
+يعني خلّينا نتذكر نقطة وأنا باعتبر يعني الأهم هي
+
+683
+01:12:42,750 --> 01:12:47,550
+وجود المفاهيم إذا أنا شكيت أنه فيه disease
+
+684
+01:12:47,550 --> 01:12:51,450
+chromosomal أو disease
+
+685
+01:12:52,750 --> 01:12:58,530
+يعني sub-chromosome أو باند فيها مشكلة شو بدي
+
+686
+01:12:58,530 --> 01:13:03,770
+أعمل؟ إذا أنا شكيت في عيلة عندها شغل زي هيك بروح
+
+687
+01:13:03,770 --> 01:13:08,910
+بعملهم بينقصين الـ karyotype الـ karyotype هو اللي
+
+688
+01:13:08,910 --> 01:13:12,930
+بيخليني أشوف الـ chromosome كله وبقدر أشوف إذا فيه
+
+689
+01:13:12,930 --> 01:13:19,090
+باند ضايعة باند منقولة باند صار فيها مشكلةوممكن
+
+690
+01:13:19,090 --> 01:13:25,910
+أستفيد من هذا الموضوع كـ Band في تشخيص أشياء معينة
+
+691
+01:13:25,910 --> 01:13:29,090
+النوع
+
+692
+01:13:29,090 --> 01:13:36,250
+الثاني من عمليات الـ Search بتكون باستخدام قطعة
+
+693
+01:13:36,250 --> 01:13:44,770
+يعني مثلًا أنا الـ الـ الـ الـ اللي حكينا الـ
+
+694
+01:13:44,770 --> 01:13:52,810
+Nucleotides زي الأحرففلما أجي أعمل Search بدي على
+
+695
+01:13:52,810 --> 01:14:00,090
+مستوى أن أحط كلمة ماشي و أدور عليها بقدر أسوي هيك
+
+696
+01:14:00,090 --> 01:14:05,130
+إذا أنا متأكد وين هي بس أنا عندى تسع مليارات حرف و
+
+697
+01:14:05,130 --> 01:14:10,570
+أني أدور فيهم كلهم بهذه الطريقة أحياناً صعب و
+
+698
+01:14:10,570 --> 01:14:15,840
+بيبقى عندى احتمالات كبيرة و لأي إنسان الـ Snapاللي
+
+699
+01:14:15,840 --> 01:14:19,840
+هي Single Nucleotide Polymorphism يعني اختلالات أو
+
+700
+01:14:19,840 --> 01:14:25,300
+اختلافات في Single Nucleotide عشر ملايين اختلال
+
+701
+01:14:25,300 --> 01:14:31,340
+عادة في أي إنسان منها فبتصير الأمور صعبة وبصير
+
+702
+01:14:31,340 --> 01:14:36,900
+يعني أني أكون بثقة متأكد من هذا الموضوع صعب
+
+703
+01:14:36,900 --> 01:14:40,900
+فالأمور اللي سووها كثير من العلماء لما ييجوا
+
+704
+01:14:40,900 --> 01:14:46,700
+يدرسوا أمراض معينة ووراثيةبيصير زي مثلًا Retinitis
+
+705
+01:14:46,700 --> 01:14:50,920
+Pigmentosa هذا النوع من الـ Disease Retinitis
+
+706
+01:14:50,920 --> 01:14:56,900
+Pigmentosa أنا بطلعلها Marker يعني أنا بكون درست
+
+707
+01:14:56,900 --> 01:15:03,440
+من قبل وين الجين وأحيانًا صعد علي أني أشوف حتى لو
+
+708
+01:15:03,440 --> 01:15:12,680
+يعني حتى لو بشوف أنه في منطقة فيها ارتباط أقوى
+
+709
+01:15:13,370 --> 01:15:18,210
+أحياناً بكون عندي صعوبة أن أتأكد أنه هل هو فعلاً
+
+710
+01:15:18,210 --> 01:15:22,350
+هذا الأمر هو المهم المثال هنا اللي بدي أحطهنيا
+
+711
+01:15:22,350 --> 01:15:30,650
+اللي هو أنه لما أنت تيجيك حالة وتيجيك عيلة أنت
+
+712
+01:15:30,650 --> 01:15:37,770
+بتكون من الـ pedigree يعني شاكك أن هذا مرض وراثي
+
+713
+01:15:37,770 --> 01:15:47,810
+وهذا مرض جينيوإذا بالذات يعني بكون يعني هذا مرض
+
+714
+01:15:47,810 --> 01:15:58,250
+وراثي وجيني بدي أفكر كيف بدي أجي أنا أعمل الأحسن
+
+715
+01:15:58,250 --> 01:16:04,730
+أنه أعمل Whole Genome Sequencing بكون قريت لكل
+
+716
+01:16:04,730 --> 01:16:09,330
+الناس إذا بالذات أنا بتكلم عن الأسرة اللي عندها
+
+717
+01:16:09,330 --> 01:16:16,210
+المرضوعندي أفراد مصابين وأفراد مش مصابين، ماشي؟
+
+718
+01:16:16,210 --> 01:16:20,050
+لما يكون عندي الـ Whole Genome Sequencing أني
+
+719
+01:16:20,050 --> 01:16:27,910
+أقارن بينهم أحياناً يعني راح يكون الأمر يعني صعب
+
+720
+01:16:27,910 --> 01:16:35,750
+جداً حتى على أقوى كمبيوتر أنه يسوي، ماشي؟ اللي
+
+721
+01:16:35,750 --> 01:16:44,470
+بتكلموا عنه هناإنه افرض أنك لقيت عيلة وعندك مجموعة
+
+722
+01:16:44,470 --> 01:16:51,450
+أفراد مصابين ومجموعة أفراد مش مصابين وقريت الـ
+
+723
+01:16:51,450 --> 01:16:54,650
+«هول
+
+724
+01:16:54,650 --> 01:16:59,370
+جينوم» الـ Sequence تبعهم وعندك إياهم وعندك
+
+725
+01:16:59,370 --> 01:17:04,890
+الكمبيوتر زي «جوجل سيرتش» بيقدر يعملك البحث بحيث
+
+726
+01:17:04,890 --> 01:17:10,010
+أنه يقارن بين المصابين وغير المصابينعندما تكون
+
+727
+01:17:10,010 --> 01:17:17,090
+عمياناً من الأول تقدر أنه ستجد حوالي أربع ملايين
+
+728
+01:17:17,090 --> 01:17:23,590
+اختلاف بين المصابين وغير المصابين يعني هذولة عدد
+
+729
+01:17:23,590 --> 01:17:29,150
+هائل جداً من الاختلافات والاحتمالية الكبرى يعني
+
+730
+01:17:29,150 --> 01:17:35,930
+إذا تتذكروا كلمة حكيتها من قبلإن حوالي 94% من الـ
+
+731
+01:17:35,930 --> 01:17:40,390
+«DNA» في الإنسان هو «Non-coding DNA» يعني
+
+732
+01:17:40,390 --> 01:17:44,890
+«Intervening DNA» الـ «DNA» ما لهوش دخل بالـ
+
+733
+01:17:44,890 --> 01:17:49,110
+Transcription و Translation و تكوين بروتين ويمكن
+
+734
+01:17:49,110 --> 01:17:53,290
+شوية له دور في الـ Regulation يعني إذا ماكنش
+
+735
+01:17:53,290 --> 01:17:58,290
+coding 100% بعضه يعني على أساس بيعتبروه بيحمي ضد
+
+736
+01:17:58,290 --> 01:18:02,540
+الـ Mutations ولو صارتخريب في هذا المكان، بس هو مش
+
+737
+01:18:02,540 --> 01:18:07,960
+مهم، مالوش قيمة فلما بتقدر أنه فيه أربع ملايين
+
+738
+01:18:07,960 --> 01:18:16,760
+اختلاف لما تلاقي، يعني تيجي تحاول تدرس أكثر مين
+
+739
+01:18:16,760 --> 01:18:22,980
+قريب على بروتين يمكن إله وظيفة مين قريب على منطقة
+
+740
+01:18:22,980 --> 01:18:34,100
+معروفة من قبل، كذا ممكن أحددهم لـ 80 ألفلما ألاقى
+
+741
+01:18:34,100 --> 01:18:41,300
+الـ 180 ألف اختلاف بحاول أشوف إذا فيه لهم نتائج
+
+742
+01:18:41,300 --> 01:18:42,940
+على الـ Messenger RNA
+
+743
+01:18:46,550 --> 01:18:55,770
+بحاول أني أقلل أو أدرس من الـ Public databases هنا
+
+744
+01:18:55,770 --> 01:19:02,450
+إذا شوه إشي معروف من قبل قريب مرتبط مع هذه الحالة
+
+745
+01:19:02,450 --> 01:19:07,190
+أو هذا المرض أو إشي قريب منه وبظلني بعدين يعني
+
+746
+01:19:07,190 --> 01:19:16,890
+أركز في الدراسة لحد ما أحاول إذا بقدر أني أحددالـ
+
+747
+01:19:16,890 --> 01:19:22,750
+Variants، أحدد ما هي الـ Alleles أو أكون بينتج عن
+
+748
+01:19:22,750 --> 01:19:27,850
+هذا الجهد كله بالأخير Segment اللي يمكن نسميه
+
+749
+01:19:27,850 --> 01:19:36,510
+Marker واللي بيسموه Candidate Gene Methodology
+
+750
+01:19:36,510 --> 01:19:42,070
+يعني اللي هي أني أنا أدور على أنهار جين اللي مرتبط
+
+751
+01:19:42,420 --> 01:19:49,820
+بقوة كاختلاق بين المصابين وبين الطبيعيين في
+
+752
+01:19:49,820 --> 01:19:57,440
+العائلة هذه في المرض هذا في الحالة هذه يعني شغل
+
+753
+01:19:57,440 --> 01:20:03,940
+نستخدمها وأحياناً في بعض الأمراض بعض العائلات بعض
+
+754
+01:20:03,940 --> 01:20:10,980
+الـ populations نشتغل هذا الشغل فمن هذا الشغل إذا
+
+755
+01:20:11,670 --> 01:20:20,310
+استطعت أجيب Marker متخصص لـ Disease معينة بصير أنا
+
+756
+01:20:20,310 --> 01:20:24,650
+بعدين كفي دراسات أخرى زي الـ Whole Genomes
+
+757
+01:20:24,650 --> 01:20:30,100
+Association Genome-Wide Association Studiesماشي
+
+758
+01:20:30,100 --> 01:20:33,120
+بسير
+
+759
+01:20:33,120 --> 01:20:37,040
+أشوف إذا الـ Marker هذا موجود بقول أه والله
+
+760
+01:20:37,040 --> 01:20:44,660
+احتمالية المرض هذا بنسبة هالقدة أكثر من الناس
+
+761
+01:20:44,660 --> 01:20:52,740
+الطبيعية فهي يعني يعني برجع مرة ثانية الأهم واحد
+
+762
+01:20:52,740 --> 01:20:56,500
+يكون فاهم المبدأ يمكن مايكونش عندنا إمكانية نطبق
+
+763
+01:20:56,500 --> 01:21:04,800
+هذه الأشياءوصراحة مرات يعني .. يعني بتكون .. شو
+
+764
+01:21:04,800 --> 01:21:10,300
+بده أسميها؟ يعني بتكون مضيعة للقدرات إن الواحد
+
+765
+01:21:10,300 --> 01:21:14,160
+يدرس أشياء كثيرة وبيكون زي ما بيقولوا Big Data
+
+766
+01:21:14,160 --> 01:21:20,240
+يكون عندك أرقام كثيرة ومعلومات كثيرة الآن إذا
+
+767
+01:21:20,240 --> 01:21:27,450
+تخيلنا الـالـ Google Search مثلاً كيف بدورلك على
+
+768
+01:21:27,450 --> 01:21:31,530
+الكلمة وبتجيبلك إياها في أي قصيدة، في أي إشي قدر
+
+769
+01:21:31,530 --> 01:21:38,770
+هو مفيد، ممكن بس هي الفكرة أن هذا الموضوع لسه
+
+770
+01:21:38,770 --> 01:21:46,470
+بحاجة لتطوير أكثر، مشاركة أكثر وانتباه للاختلافات
+
+771
+01:21:46,980 --> 01:21:55,100
+يعني حتى لو لقينا إشي يمكن زابط كنسبة في الأمركام
+
+772
+01:21:55,100 --> 01:22:00,260
+في البيض في السود في كده قد لا يكون بالضرورة هو
+
+773
+01:22:00,260 --> 01:22:07,580
+اللي عنا إحنا كمثلًا عرب أو في منطقة الشرق الأوسط
+
+774
+01:22:07,580 --> 01:22:12,560
+أو بلاد الشام أو كده يعني هذه اختلافات بدي الواحد
+
+775
+01:22:12,560 --> 01:22:18,840
+يتنبأ إليها الأهم من هيك يكون الواحد منناعنده تصور
+
+776
+01:22:18,840 --> 01:22:26,720
+على معنى اللي بيقراه وبيشوفه لما نتكلموا على إن
+
+777
+01:22:26,720 --> 01:22:31,600
+هذا Marker للـ Disease يعني يفهمها الواحد، ونتيجة
+
+778
+01:22:31,600 --> 01:22:36,480
+الـ Marker نتيجة حدوث ظاهرة الـ Recombination و
+
+779
+01:22:36,480 --> 01:22:41,200
+الـ Crossover و الـ Linkage Dysequilibrium في
+
+780
+01:22:41,200 --> 01:22:46,280
+تفاوت بين الـ Markers، يعنيقد لا يكون الـ Marker
+
+781
+01:22:46,280 --> 01:22:52,700
+اللي بتستخدمه هو السليم أحكوا، ده فيه أسئلة؟ إيه،
+
+782
+01:22:52,700 --> 01:22:57,820
+كريم بده يتكلم في استفسارين؟ نعم، فضل يا كريم
+
+783
+01:22:57,820 --> 01:23:01,380
+باعظك
+
+784
+01:23:01,380 --> 01:23:04,560
+صورة في الـ chats ممكن برضه مقال ممكن تعرفي شوفها
+
+785
+01:23:04,560 --> 01:23:10,600
+شول أحكي أحكيها كمبدأ يعني ما الصورة هيك أثبت ده
+
+786
+01:23:10,600 --> 01:23:20,380
+قد أنزله كدهلأن جيتها في الـ «بديجري» ‏- أه ‏- في
+
+787
+01:23:20,380 --> 01:23:24,480
+حالة الـ «بديجري» ‏- أه ‏- لما تكون مثلا في ميل
+
+788
+01:23:24,480 --> 01:23:27,460
+محطومك تحتها ساهم واحد ‏- أه ‏- بدون ما تكون عاملة
+
+789
+01:23:27,460 --> 01:23:37,800
+تزاوج ‏- أه ‏- مع ميل الآخر ‏- خليني أشوف ‏- أه ‏-
+
+790
+01:23:37,800 --> 01:23:40,160
+عرضت الصورة أنا يا دكتور ‏- أه ‏- حملتها وعرضتها
+
+791
+01:23:40,160 --> 01:23:47,470
+أنا ‏- أههي موجودة أكتر من قديم، مش الموضوع الـ X
+
+792
+01:23:47,470 --> 01:23:52,410
+-linked dominant inheritance disorder الـ X-linked
+
+793
+01:23:52,410 --> 01:23:52,530
+dominant inheritance disorder الـ X-linked
+
+794
+01:23:52,530 --> 01:23:54,270
+dominant inheritance disorder الـ X-linked
+
+795
+01:23:54,270 --> 01:23:54,490
+dominant inheritance disorder الـ X-linked
+
+796
+01:23:54,490 --> 01:23:56,190
+dominant inheritance disorder الـ X-linked
+
+797
+01:23:56,190 --> 01:23:56,510
+dominant inheritance disorder الـ X-linked
+
+798
+01:23:56,510 --> 01:23:56,930
+dominant inheritance disorder الـ X-linked
+
+799
+01:23:56,930 --> 01:23:58,890
+dominant inheritance disorder الـ X-linked
+
+800
+01:23:58,890 --> 01:23:58,970
+dominant inheritance disorder الـ X-linked
+
+801
+01:23:58,970 --> 01:23:59,090
+dominant inheritance disorder الـ X-linked
+
+802
+01:23:59,090 --> 01:23:59,350
+dominant inheritance disorder الـ X-linked
+
+803
+01:23:59,350 --> 01:23:59,750
+dominant inheritance disorder الـ X-linked
+
+804
+01:23:59,750 --> 01:24:01,270
+dominant inheritance disorder الـ X-linked
+
+805
+01:24:01,270 --> 01:24:04,210
+dominant inheritance disorder الـ X-linked
+
+806
+01:24:04,210 --> 01:24:06,890
+dominant inheritance disorder الـ X-linked
+
+807
+01:24:06,890 --> 01:24:09,260
+dominant inheritance disorder الـ X-linkedلما
+
+808
+01:24:09,260 --> 01:24:12,080
+يعطيك حالة في الحالة هذه يقول لك اللي هو ال female
+
+809
+01:24:12,080 --> 01:24:16,480
+أنا تزوجها اللي معها يكون افترضه دايما سليم ولا
+
+810
+01:24:16,480 --> 01:24:24,000
+ممكن يكون mutant عادي؟ ما هو ليش ماحطهاش؟ لأنه
+
+811
+01:24:24,000 --> 01:24:31,400
+ماعنديش معلومة فاهم عليك كيف؟ يعني هنا الـ بكتير
+
+812
+01:24:31,400 --> 01:24:33,080
+احسانات نعم
+
+813
+01:24:36,400 --> 01:24:40,700
+كتير في صور زيكي في الكتاب بيكون حاطة كل .. بقولك
+
+814
+01:24:40,700 --> 01:24:43,620
+كتير في صور تكون في الكتاب حاطة نفس ال .. الوصف
+
+815
+01:24:43,620 --> 01:24:47,060
+نفسها معين في degree وعمل بس أفره زيكي من دون أن
+
+816
+01:24:47,060 --> 01:24:50,880
+يعمل تزاوج فاهمت أنها .. هذي بتكون ال .. أنه مش
+
+817
+01:24:50,880 --> 01:24:53,960
+عارف ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+818
+01:24:53,960 --> 01:24:55,520
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+819
+01:24:55,520 --> 01:24:55,800
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+820
+01:24:55,800 --> 01:24:58,640
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+821
+01:24:58,640 --> 01:24:58,960
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+822
+01:24:58,960 --> 01:25:00,020
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+823
+01:25:00,020 --> 01:25:00,420
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+824
+01:25:00,420 --> 01:25:08,610
+.. ال .. ال .. ال .. الماوصلتوش، فاهم علي؟ يعني
+
+825
+01:25:08,610 --> 01:25:16,050
+أنا جيت أعملت دراسة على عائلة معينة والأبو مسافر،
+
+826
+01:25:16,050 --> 01:25:21,750
+مش في البلد، مش في المنطقة، فأه الفكرة أنه ماعنديش
+
+827
+01:25:21,750 --> 01:25:25,930
+معلومة عنه، بس طبعاً لازم عشان خلفت، لازم اتزوجت
+
+828
+01:25:25,930 --> 01:25:33,350
+مع شخص آخر، و بفترض أنه سليم، ماشي؟لو كنت عرفت
+
+829
+01:25:33,350 --> 01:25:38,690
+منها إنه مصاب من نفس الإصابة بدا أحطه بس الفكرة
+
+830
+01:25:38,690 --> 01:25:44,890
+هنا إنه هذه كـ Disease أو بـ degree لظاهرة إنه إذا
+
+831
+01:25:44,890 --> 01:25:50,710
+في صفة X-linked dominant إذا الـ X-linked dominant
+
+832
+01:25:50,710 --> 01:25:55,850
+إحنا عادة نتكلم X-linked recessive الـ X-linked
+
+833
+01:25:55,850 --> 01:26:01,910
+dominant الأنثى لو عنده نسخة واحدةبتلاقيها يعني
+
+834
+01:26:01,910 --> 01:26:07,230
+نسخة واحدة مصابة والثاني سليمة بتلاقيها بنتج على
+
+835
+01:26:07,230 --> 01:26:14,550
+أنه عندها المرض بينما الذكر لما يكون مصاب ماشي بس
+
+836
+01:26:14,550 --> 01:26:18,950
+ماعندهوش نسخة ثانية تكون سليمة يعني تمشيه فاللي
+
+837
+01:26:18,950 --> 01:26:24,330
+بيصير عنده زي هيك الـ Inheritance بيكون أنه الذكر
+
+838
+01:26:24,330 --> 01:26:30,800
+lethalيعني مافيش ذكر مصاب بهذا المرض اللي لما
+
+839
+01:26:30,800 --> 01:26:37,060
+يطلعوا بهذا الشكل بيكونوا high autism X-linked
+
+840
+01:26:37,060 --> 01:26:42,720
+dominant، ماشي؟ يعني هاي اللي انه ال females كلها
+
+841
+01:26:42,720 --> 01:26:49,040
+مصابات مش carriers، ماشي؟ مع أنه عندها one copy بس
+
+842
+01:26:49,040 --> 01:26:55,360
+مصابة وال .. وال males وال females ال males كلهم
+
+843
+01:26:55,360 --> 01:27:01,390
+الموجودينفيش حد مصاب، ماشي؟ وبالتالي يعني كلهم
+
+844
+01:27:01,390 --> 01:27:07,750
+لازم يكونوا normal، واضحة؟ تمام، الـ Homework اللي
+
+845
+01:27:07,750 --> 01:27:12,130
+حصلت عليها اليوم ال assignment كل قليل القصة و
+
+846
+01:27:12,130 --> 01:27:14,910
+لحاله يعني الـA لحاله، الـB لحاله، الـC لحاله،
+
+847
+01:27:14,910 --> 01:27:17,770
+الـD لحاله، الـE لحاله يعني هي الموضوع أعقد من
+
+848
+01:27:17,770 --> 01:27:24,420
+الطبيعي، ماشي؟الـ «A» والـ «B» بدنا نفصلهم عن بعض،
+
+849
+01:27:24,420 --> 01:27:31,580
+بدك تتأكد بالرياضيات إنه الفصل بالمعادلة سليم، آه
+
+850
+01:27:31,580 --> 01:27:36,220
+«A» هياخد مثلا اللي هو الـ «B» ورمز «B» والـ «A»
+
+851
+01:27:36,220 --> 01:27:42,240
+والـ «S» هو اللي هياخد الـ «Q»، صحيح؟ الـ «B» اللي
+
+852
+01:27:42,240 --> 01:27:46,300
+هو راح يكون الـ «A» والـ «B» مع بعض، بدك تحسبها
+
+853
+01:27:46,300 --> 01:27:54,400
+هيك، ماشي؟والـ AB هو الـ Heterozygous ماشي؟ يعني
+
+854
+01:27:54,400 --> 01:28:00,040
+تجربها و بيخليها للمرة الجاية بنحلنا كلها و بنشوف
+
+855
+01:28:00,040 --> 01:28:03,220
+شو بيطلع معاكم و أنا بقولكم شو النتيجة و بنشوف شو
+
+856
+01:28:03,220 --> 01:28:08,140
+بيطلع معايا أنا كمان خليني أشوفها يعني أسهل إشي
+
+857
+01:28:08,140 --> 01:28:15,560
+للـ O أسهل إشي للـ O لأن أنا Recessive
+
+858
+01:28:15,560 --> 01:28:21,910
+أه طيبالله يحضرك اللي هيطلع يعني لكل نسبتين
+
+859
+01:28:21,910 --> 01:28:30,830
+نسبتين؟ أه يحضر اللي هيطلع لكل قليل نسبتين لأ كيف
+
+860
+01:28:30,830 --> 01:28:35,150
+لكل قليل نسبتين الـ O بدك تطلع لكل قليل نسبتين
+
+861
+01:28:35,150 --> 01:28:42,610
+وبعدين تحسب لـ A و لـ B تفصلهم عن بعض هو الـ code
+
+862
+01:28:42,610 --> 01:28:46,110
+of general الـ S4 و الـ B4 نعم
+
+863
+01:28:50,210 --> 01:28:58,450
+مافيش a small و b small فاهم عليك؟ في a و o دول ال
+
+864
+01:28:58,450 --> 01:29:02,590
+capital A و small a هيك بدك تاخدهم و ال capital B
+
+865
+01:29:02,590 --> 01:29:11,130
+و small بيه مش small بيه فيه o ماشي بدك تجربها
+
+866
+01:29:11,130 --> 01:29:15,950
+شوفها ماشي الله يعطيكم العافية يعطيك ألف عافية
+
+867
+01:29:15,950 --> 01:29:21,560
+دكتورالله يرضى عليك جمال بدك الأسئلة على ال word
+
+868
+01:29:21,560 --> 01:29:25,260
+صح؟ وكل واحدة عليها الإجابة ان شاء الله رب
+
+869
+01:29:25,260 --> 01:29:29,480
+العالمين لسه شغال عليها و بس أخلص و أبعتلك إياها
+
+870
+01:29:29,480 --> 01:29:41,640
+تمام يا عزيزي يا عزيزي الله يسهل
+
+871
+01:29:41,640 --> 01:29:44,540
+الله يسهل الله يسهل الله يسهل الله يسهل الله يسهل
+
+872
+01:29:44,540 --> 01:29:46,360
+الله يسهل الله يسهل الله يسهل الله يسهل الله يسهل
+
+873
+01:29:46,360 --> 01:29:47,080
+الله يسهل الله يسهل الله يسهل الله يسهلالعزيزي
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/td1N2Fp6EAU_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/td1N2Fp6EAU_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..251b9f3134e9c0b53363e61e6fc2aa445193c3a1
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/td1N2Fp6EAU_postprocess.srt
@@ -0,0 +1,3504 @@
+1
+00:00:00,000 --> 00:00:02,400
+مرحبًا ورحمة الله وبركاته بسم الله الرحمن الرحيم
+
+2
+00:00:02,400 --> 00:00:10,300
+دائمًا نحكي إنه في بداية أي محاضرة إذا حد عنده
+
+3
+00:00:10,300 --> 00:00:15,520
+استفسار عن ما تم ذكره أو شرحه من قبل أو ما تم
+
+4
+00:00:15,520 --> 00:00:19,780
+مناقشته
+
+5
+00:00:19,780 --> 00:00:23,300
+في المحاضرات السابقة ممكن واحد يبدأ نسأل يعني قبل
+
+6
+00:00:23,300 --> 00:00:28,060
+ما نبدأ المحاضرة المحاضرة
+
+7
+00:00:28,060 --> 00:00:39,140
+اليومهو الفصل الثالث عشر من الكتاب حقيقةً يعني فيه
+
+8
+00:00:39,140 --> 00:00:50,740
+معلومات صعوبة فيها أن بعضها عبارة عن علاجات وطرق
+
+9
+00:00:50,740 --> 00:00:58,020
+علاج يعني نسميها تجربية فبالتالي الـ
+
+10
+00:00:58,930 --> 00:01:06,030
+اللي قد لا تكون كلها من الأشياء المثبتة المعتمدة
+
+11
+00:01:06,030 --> 00:01:16,030
+اللي approved ويمكن استخدامها بس مش غلط إنه الواحد
+
+12
+00:01:16,030 --> 00:01:23,470
+ينتبه لمستويات علاجات ومعالجة الأمراض الوراثية
+
+13
+00:01:23,470 --> 00:01:27,050
+بالنسبة
+
+14
+00:01:27,050 --> 00:01:34,470
+لـمحاضرة اليوم أنا بظن يعني من أهم الأشياء اللي
+
+15
+00:01:34,470 --> 00:01:43,630
+يعني بتعطينا هيكة للعلاجات الممكنة بيظل العلاج
+
+16
+00:01:43,630 --> 00:01:52,350
+الأخير في الأسفل وهو العلاج على مستوى العائلة الـ
+
+17
+00:01:52,350 --> 00:01:55,750
+Genetic Counseling الـ Career Screening الـ Pre
+
+18
+00:01:55,750 --> 00:02:01,970
+-Symptomatic Diagnosisمبادئ من الطرق
+
+19
+00:02:01,970 --> 00:02:07,870
+العلاج اللي أحيانًا تتفاوت وحسب الحالة وحسب المرض
+
+20
+00:02:07,870 --> 00:02:16,190
+وسيكون هناك إن شاء الله فصل لاحق في المثاق
+
+21
+00:02:16,190 --> 00:02:22,450
+عن آليات وكيفية عمل الـGenetic Counseling ما هي
+
+22
+00:02:22,450 --> 00:02:28,740
+مبادئه وكيف ده نسويه وشو بنعمل فيه والأشياء هذهإذا
+
+23
+00:02:28,740 --> 00:02:36,280
+افترضنا إن الأمراض اللي ناتجة عن خلل في الجينات
+
+24
+00:02:36,280 --> 00:02:43,620
+بالأخير راح تظهر بروتيم معين لأن الجين هو الشفرة
+
+25
+00:02:43,620 --> 00:02:50,200
+الوراثية لبروتينات معينة وبالتالي سيكون المحصلة هو
+
+26
+00:02:50,200 --> 00:02:56,890
+إنتاج بروتيم معينمستويات العلاجات أو مستويات أنواع
+
+27
+00:02:56,890 --> 00:03:05,850
+التدخلات الممكنة ممكن أن نقوم بتعديل نفس الجين
+
+28
+00:03:05,850 --> 00:03:16,520
+المصاب يعني طبعاً هذه قضية كبيرة جداً وهناكفي
+
+29
+00:03:16,520 --> 00:03:21,760
+صعوبة بالغة بتعديل الجين أي إنسان إذا ذكرنا إن هذه
+
+30
+00:03:21,760 --> 00:03:26,880
+الجينات والمادة الوراثية في كل الخلايا متشابهة
+
+31
+00:03:26,880 --> 00:03:32,580
+والأصل إنها محددة من لحظة التكون والتخلق عند تلقيح
+
+32
+00:03:32,580 --> 00:03:39,550
+البائظة فمن تلك اللحظة الأصل أنهكل المادة الوراثية
+
+33
+00:03:39,550 --> 00:03:44,470
+في كل الخلايا ناتجة متشابهة إلا إذا حصلت عملية
+
+34
+00:03:44,470 --> 00:03:56,010
+طفرات غير مخططة لها، فبتكون تحدث فأحياناً نستطيع
+
+35
+00:03:56,010 --> 00:04:06,010
+أن نغير في الـSomatic Genotype يعني في خلايا الجسم
+
+36
+00:04:06,010 --> 00:04:15,060
+بعد ذلكويعني هذه قضية بتكون في حالات محددة بقضية
+
+37
+00:04:15,060 --> 00:04:20,120
+نقل الأعضاء اللي هو مثلًا أو أسهلها من هذه الناحية
+
+38
+00:04:20,120 --> 00:04:25,080
+هي قضية للأشياء الوراثية عملية نقل النخاع العظيم
+
+39
+00:04:25,080 --> 00:04:29,080
+أو يمكن الـ Stem Cells اللي هي الخلايا الجدعية
+
+40
+00:04:29,080 --> 00:04:34,540
+بطريقة علاج ففيه هناك بعض الأمراض ما يمكن استخدام
+
+41
+00:04:34,540 --> 00:04:36,820
+هذا الأسلوب
+
+42
+00:04:38,610 --> 00:04:45,550
+لأن هناك محاولات أخرى يعني الإشكالية إنك كيف تدخل
+
+43
+00:04:45,550 --> 00:04:52,270
+الـ «جين» في داخل النواة، في داخل الخلية، في كل
+
+44
+00:04:52,270 --> 00:04:58,790
+خلية يعني، فهي الأمر مش سهل، فهناك محاولات أخرى
+
+45
+00:04:58,790 --> 00:05:08,470
+لإعطاء أدوية لتغيير الـ «جين» expressionوهو نابع
+
+46
+00:05:08,470 --> 00:05:14,730
+يعني كمثال أيضًا من الـ Sickle Cell باستخدام دوة
+
+47
+00:05:14,730 --> 00:05:21,490
+اللي هو Dicetabine ولحد
+
+48
+00:05:21,490 --> 00:05:27,010
+الآن يعني هو تجريبي، الكلام قديم شوية في الكتاب
+
+49
+00:05:27,010 --> 00:05:33,890
+تبعكم ويمكن أن أصبح مقبول أكثر، بحاول بطريقة فهم
+
+50
+00:05:35,370 --> 00:05:40,390
+العوامل اللي تتحكم في الـ Gene والـ Gene
+
+51
+00:05:40,390 --> 00:05:49,910
+Expression ممكن الواحد يعني يصلح ويزيد من إفراز أو
+
+52
+00:05:49,910 --> 00:05:57,950
+تكوين Gene معين هناك محاولات
+
+53
+00:05:58,580 --> 00:06:04,320
+عن طريق أقباء اللي هو الـ Mutant Messenger RNA
+
+54
+00:06:04,320 --> 00:06:08,000
+عشان
+
+55
+00:06:08,000 --> 00:06:11,760
+نكون بتدخل
+
+56
+00:06:11,760 --> 00:06:18,080
+وبتحطيم بروتين أحنا لا نرغب فيه زي الـ Amylodosis
+
+57
+00:06:18,080 --> 00:06:21,640
+كمرض
+
+58
+00:06:21,640 --> 00:06:28,500
+يعنيسواء مرات أنواع منه الـ Amyloid deposits مثلًا
+
+59
+00:06:28,500 --> 00:06:33,440
+بالـ Alzheimer أو في مثلًا نفس الـ Classical
+
+60
+00:06:33,440 --> 00:06:38,220
+Amyloidosis الـ Amyloidosis، هذا مرات راح نحكي عنه
+
+61
+00:06:38,220 --> 00:06:47,710
+أحيانًا نقوم بالـ Protein Replacement يعنيإنه ماشي
+
+62
+00:06:47,710 --> 00:06:53,950
+هذا الإنسان عنده بروتين مصعب أنا بعطي زي مثلا واحد
+
+63
+00:06:53,950 --> 00:06:58,470
+عنده homophilia أو نقص factor A بسير بشكل عند
+
+64
+00:06:58,470 --> 00:07:03,850
+الاحتياج أو بشكل متكرر بعطي cryoprecipitate أو
+
+65
+00:07:03,850 --> 00:07:09,690
+بعطي recomponent factor A أو كده أو مثلا زي حالات
+
+66
+00:07:09,690 --> 00:07:13,670
+مرض الـ Goucher اللي هو من الـ Metabolic Diseases
+
+67
+00:07:14,210 --> 00:07:21,550
+بيكون فيه نقص إنزايم معين «جلوكو سيريبرو سيديز»
+
+68
+00:07:21,550 --> 00:07:27,090
+بيصير نعطيها بلاحظ أنه بيفيد وبحسن وكذا أحياناً
+
+69
+00:07:27,090 --> 00:07:32,090
+التأثير على الـ Mutant Protein بتغيير أو بتعويض أو
+
+70
+00:07:32,090 --> 00:07:41,830
+بتداخل مع إعطاء الـإذا كان من المشاكل إن وظيفة
+
+71
+00:07:41,830 --> 00:07:46,970
+البروتين صارت أضعف نعطيه إشي بيخلي وظيفة البروتين
+
+72
+00:07:46,970 --> 00:07:51,630
+هذا أقوى وأحسن وبنحسنها فالـ Pyridoxin in classic
+
+73
+00:07:51,630 --> 00:08:01,250
+hemocystinuria بيكون تحسين يعني الآن عن طريق فهمنا
+
+74
+00:08:01,250 --> 00:08:02,810
+لـ
+
+75
+00:08:06,170 --> 00:08:12,510
+اليّة المرض مثلًا مثلًا الـ Phenylketonuria ومعرفة
+
+76
+00:08:12,510 --> 00:08:16,110
+العامل المسبب للأعراض مثلًا مثلًا مثلًا الـ
+
+77
+00:08:16,110 --> 00:08:22,090
+Phenylalanine في هذه الحالة ممكن أنا أدخل أنه أطلب
+
+78
+00:08:22,090 --> 00:08:27,330
+أنه نغيّر الحمية تبع الإنسان هذا الـ Dietary
+
+79
+00:08:27,330 --> 00:08:31,370
+Intervention بحيث أنه نعطيه لو Phenylalanine، ديات
+
+80
+00:08:31,370 --> 00:08:34,910
+أو لو بروتين، ديات بشكل عام، بالذات إذا فيه بروتين
+
+81
+00:08:35,920 --> 00:08:41,420
+high with phenylalanine حيث أنه نمنع أعراض تبعات
+
+82
+00:08:41,420 --> 00:08:45,380
+المرض ما نتدخل في البروتين، ما نتدخل في الجيل على
+
+83
+00:08:45,380 --> 00:08:50,760
+مستوى الـ Metabolic Metabolism أو على مستوى نفس
+
+84
+00:08:50,760 --> 00:08:56,600
+الألية
+
+85
+00:08:56,600 --> 00:09:02,100
+تبع التسبب بالمرض، استخدمها في علاجه في
+
+86
+00:09:02,100 --> 00:09:07,690
+الـUricicle defects مثلاًالـ Sodium Benzoate برضه
+
+87
+00:09:07,690 --> 00:09:15,490
+بيغير وبعدل في آليات تسبب
+
+88
+00:09:15,490 --> 00:09:24,290
+المرض والـ pathogenesis أحيانًا ندخل لتخفيف مظهر
+
+89
+00:09:24,290 --> 00:09:27,610
+المرض مثلًا اللي عنده ثلاثيميا أو Sickle Cell أصير
+
+90
+00:09:27,610 --> 00:09:33,910
+يعطيه Blood Transfusionمثلًا Surgical Intervention
+
+91
+00:09:33,910 --> 00:09:37,290
+مثلًا Correction of Congenital Heart Disease إذا
+
+92
+00:09:37,290 --> 00:09:45,330
+كان مرض نتيجته إنه فيه مثلًا خلل خلقي أو عيب خلقي
+
+93
+00:09:45,330 --> 00:09:51,770
+في القلب، برجي وأنا بتدخل فيعني اللي بد الواحد
+
+94
+00:09:51,770 --> 00:09:59,570
+يتذكره إنه أنا أحيانًا قد يكون عنديأليات، طبعًا كل
+
+95
+00:09:59,570 --> 00:10:05,190
+هذه التداخلات
+
+96
+00:10:05,190 --> 00:10:12,890
+الإلاجية بهذا الشكل بتقوم على أساس لازم يكون بعد
+
+97
+00:10:12,890 --> 00:10:18,610
+التفكير والتقدير والفهم
+
+98
+00:10:18,610 --> 00:10:26,070
+الـ Pathogenesis بيقوم الواحد بتطوير الدواء لتعطيل
+
+99
+00:10:26,070 --> 00:10:35,980
+أوتحسين جانب معين فنعمل بعدين دراسات حول هذه الطرق
+
+100
+00:10:35,980 --> 00:10:43,000
+من العلاجات وده طريقة العلاج نجحت
+
+101
+00:10:43,000 --> 00:10:50,440
+وسببت بشكل متكرر أثبتت
+
+102
+00:10:50,440 --> 00:10:57,630
+الدراسة منتحسين الوضع بيصير يعتمد وينشر وينقش في
+
+103
+00:10:57,630 --> 00:11:03,930
+المؤتمرات ويقيم الخبراء ويجرب الناس على مستوى أكبر
+
+104
+00:11:03,930 --> 00:11:11,470
+وأكبر وأكبر ومش غلط أن الواحد يكون منتبه لهذه
+
+105
+00:11:11,470 --> 00:11:16,770
+الخيارات من الإلاجات حتى يشترك
+
+106
+00:11:16,770 --> 00:11:21,850
+في علاج كثير من الأمراضكل واحد حسب خبرته حسب اللي
+
+107
+00:11:21,850 --> 00:11:28,490
+بيشوفه بحسب يعني بدها في شكل كبير مراكز متخصصة
+
+108
+00:11:28,490 --> 00:11:36,650
+بدها ناس اشتغلت على هذه العلاجات حتى يعني يقيمها
+
+109
+00:11:36,650 --> 00:11:42,430
+الإنسان ويشوف درجة نجاحها فـ
+
+110
+00:11:46,320 --> 00:11:55,740
+الدراسات تتفاوت أيش الأشياء الممكن استخدامها يعني
+
+111
+00:11:55,740 --> 00:12:04,360
+هذه هنا
+
+112
+00:12:04,360 --> 00:12:16,640
+ملخص مرة ثانيةلأنواع الإلاجات بشكل مجمل هنا لأمراض
+
+113
+00:12:16,640 --> 00:12:27,860
+الوراثية الـ Mandelian وبقوم نسبة نوعية استفادة
+
+114
+00:12:27,860 --> 00:12:34,160
+الناس منها ضمن دراسة معينة في وقت معين، ماعرفش كم
+
+115
+00:12:34,160 --> 00:12:40,690
+مرض هنايعني العدد الكلي للأمراض اللي تم تقييمها
+
+116
+00:12:40,690 --> 00:12:48,350
+ويعني نسبة الاستفادة منها ولدرجة قبولها كطريقة
+
+117
+00:12:48,350 --> 00:12:55,810
+إلاج نتكلم في الـProduct Replacement مثلاً زي الدم
+
+118
+00:12:55,810 --> 00:13:00,690
+في حالة الثلاثيمية Substrate Restriction مثلاً
+
+119
+00:13:00,690 --> 00:13:02,090
+الـDietary
+
+120
+00:13:04,440 --> 00:13:10,020
+مثلًا مثلًا الـ Phenylalanine والبروتينز الـ Bq
+
+121
+00:13:10,020 --> 00:13:13,540
+الـ Toxin Removal الـ Coenzyme Supplementation الـ
+
+122
+00:13:13,540 --> 00:13:16,680
+Inhibition of Toxic أو الـ Toxin Production أو الـ
+
+123
+00:13:16,680 --> 00:13:21,160
+Effect الـ Enzyme Replacement Therapy يعني مش شايف
+
+124
+00:13:21,160 --> 00:13:28,380
+إنه فرق كتير عن رقم واحد الخلايا اللي يعني ممكن
+
+125
+00:13:28,380 --> 00:13:35,120
+نفكر فيهالتعويض الـ gene في الإنسان المصاب تتفاوت
+
+126
+00:13:35,120 --> 00:13:39,000
+بين liver transplantation، bomber transplantation،
+
+127
+00:13:39,000 --> 00:13:42,460
+kidney transplantation البوميرو معاه الـ stem cell
+
+128
+00:13:42,460 --> 00:13:51,940
+في مرات كثيرة يعني فهدولة النسبأنا بظن يعني مش غلط
+
+129
+00:13:51,940 --> 00:13:58,000
+الواحد يتطلع عليها من مش مفيدة ويعني هي دراسة في
+
+130
+00:13:58,000 --> 00:14:04,800
+لحظة معينة على 57 مرض هنا في حالة Inborn Errors of
+
+131
+00:14:04,800 --> 00:14:09,520
+Metabolism يعني هدولة Specifically مجموعة أمراض
+
+132
+00:14:09,520 --> 00:14:14,960
+اللي فيها بالأخيرأو مشكلتهم مع ميتابوليزم
+
+133
+00:14:14,960 --> 00:14:17,640
+ومتابولكات المشروعات الموجودة في الشخص
+
+134
+00:14:23,040 --> 00:14:28,860
+الفكرة أنه كمان يعني هيك بشكل مجمل من دراسة محددة
+
+135
+00:14:28,860 --> 00:14:36,480
+نفسها اللي عرضناها قبل شوية أنه من سنة الـ 1983
+
+136
+00:14:36,480 --> 00:14:44,980
+هما 57 مرض و31 حالة
+
+137
+00:14:44,980 --> 00:14:51,550
+أو مرضيعني حتى العلاج اللي احنا بنحكي عنه بتلاقي
+
+138
+00:14:51,550 --> 00:14:58,190
+فيه No Response يعني الأفكار والطرق العلاجات كانت
+
+139
+00:14:58,190 --> 00:15:05,490
+مرتفعة من 57 يعني أكثر من النص بكثير كان فيه عدم
+
+140
+00:15:05,490 --> 00:15:14,850
+استجابة فيه 17% بتكون في استجابةبسيطة أو محدودة 9
+
+141
+00:15:14,850 --> 00:15:20,630
+على 9 أمراض الاستجابة أقل والنسبة عادة أقل بكثير
+
+142
+00:15:20,630 --> 00:15:27,370
+مافيش response هذا الكلام سنة الـ83 كل ما نتقدم
+
+143
+00:15:27,370 --> 00:15:33,670
+بالـ93 وأخرش دراسة بالـ2008 فراحة الكلمة الـ2008
+
+144
+00:15:34,230 --> 00:15:38,970
+بتقول إن هذه الدراسة قديمة جداً لأنه الآن يعني
+
+145
+00:15:38,970 --> 00:15:44,830
+عادةً خلال 12 سنة بتلاقي فيه تقدم أشد بكثير ويمكن
+
+146
+00:15:44,830 --> 00:15:50,710
+كان راح يعملوا دراسة يكملوا النتيجة الفكرة أنهمع
+
+147
+00:15:50,710 --> 00:15:57,210
+تقدم الوقت وحتى الكلام لسنة 2008 النسب صارت بالعكس
+
+148
+00:15:57,210 --> 00:16:01,110
+يعني صار عندنا أمراض أكثر من كثير عشرين مرات
+
+149
+00:16:01,110 --> 00:16:07,590
+تقريبًا نتوقع استجابة كاملة فيعني الفكرة أنه مع
+
+150
+00:16:07,590 --> 00:16:16,980
+فهم الأدب للمرض والـ Mechanism تبعهالجين تبعته،
+
+151
+00:16:16,980 --> 00:16:20,960
+الخلل كيف يكون في الجين وتأثير الخلل على البروتين
+
+152
+00:16:20,960 --> 00:16:28,060
+وتأثير البروتين الوظيفي كل الفهم هذا بيعطينا مع
+
+153
+00:16:28,060 --> 00:16:38,080
+تقدم الطب والعلم والفهم أدوات أقوى إننا نحسن المرض
+
+154
+00:16:38,080 --> 00:16:43,960
+ونخفف آثارهطبعاً بيظل أنه يعني النقطة اللي راح
+
+155
+00:16:43,960 --> 00:16:51,380
+ناخدها زي ما حكينا في محاضرة لاحقة قضية منع المرض
+
+156
+00:16:51,380 --> 00:16:54,160
+الـ Prevention يعني اللي هو الـGenetic Counseling
+
+157
+00:16:54,160 --> 00:17:00,320
+الـFamily Planning الـTesting الأشياء هذه اللي هي
+
+158
+00:17:00,320 --> 00:17:06,060
+برضه بتساعد أنه نمنع المرض حتى احتمالية حدوثه قبل
+
+159
+00:17:06,060 --> 00:17:09,440
+حدوثه يعني فهي مبادئ عامة
+
+160
+00:17:17,690 --> 00:17:26,330
+أحيانًا الأنواع من الأمراض إذا ثبتت بتكلموا عن إنه
+
+161
+00:17:26,330 --> 00:17:33,830
+ممكن أنا أحاول أعطي حتى الدواء في المرحلة الجنينية
+
+162
+00:17:33,830 --> 00:17:41,500
+يعني الـPrenatal الـPrenatal يعنيفي مرحلة جنينية
+
+163
+00:17:41,500 --> 00:17:54,660
+لسة قبل الولادة ماشي فإذا ثبت تشقيص أو نتيجة حالات
+
+164
+00:17:54,660 --> 00:18:01,640
+سابقة مع فحص الحامل
+
+165
+00:18:01,640 --> 00:18:09,140
+طبعاً هي وزوجها وأحياناً فحص جزء من الجنين عن طريق
+
+166
+00:18:11,280 --> 00:18:16,000
+فيتال، مثلًا الـ Sampling أحيانًا باخده من الـ
+
+167
+00:18:16,000 --> 00:18:21,680
+Machina أحيانًا باخده من الـ Ammoniotic Fluid بحطه
+
+168
+00:18:21,680 --> 00:18:27,620
+إبرة دقيقة جدًا في السائل حوالين الجنين وباخده منه
+
+169
+00:18:27,620 --> 00:18:33,280
+عينة وإذا عندك إمكانية تفحص على السبق النوعي يعني
+
+170
+00:18:33,280 --> 00:18:37,460
+الطفرة الوراثية المسببة للمرض ممكن يكون عندك خيار
+
+171
+00:18:37,460 --> 00:18:41,490
+إنك تعطي دوة أحيانًايعني هذه ظاهرة بتحدث إنك أنت
+
+172
+00:18:41,490 --> 00:18:49,150
+تعطي الأم يعني دوة أو شيء ممكن يخفف المرض يعني
+
+173
+00:18:49,150 --> 00:18:57,670
+أسرع أو أشع مرض أو حالة ممكن الواحد يخفف منها
+
+174
+00:18:57,670 --> 00:19:02,700
+بالعلاج اللي في خلال الحملمثلًا الـ Folic Acid هو
+
+175
+00:19:02,700 --> 00:19:08,200
+الـ «نيرونال دي فاكت» في الفتيات يعني الـ «نيرونال
+
+176
+00:19:08,200 --> 00:19:11,560
+دي فاكت» اللي هو الـ «نيرونال تيوب» أخدته في الـ
+
+177
+00:19:11,560 --> 00:19:17,600
+Empyrogenesis إن الجهاز العصبي في الإنسان يتكون عن
+
+178
+00:19:17,600 --> 00:19:26,050
+طريقالقناعة بالأول وبعدين بتلف بالكامل وبصير يعني
+
+179
+00:19:26,050 --> 00:19:31,850
+على شكل أنبوب عصبي هذا الأنبوب آخرته من فوق ومن
+
+180
+00:19:31,850 --> 00:19:37,450
+تحت المفروض يسكر ويضم ويلتم ففي حالة Spina Bifida
+
+181
+00:19:37,450 --> 00:19:43,610
+اللي هو الدرجات وأنواع وما قد تكون مفتوحة كثير
+
+182
+00:19:43,610 --> 00:19:54,660
+مفتوحة قليل فالـ Spina Bifidaيعني هذه حالة يعني
+
+183
+00:19:54,660 --> 00:20:00,360
+صراحة إذا الطفل يُصاب فيها إعاقة عصبية شديدة
+
+184
+00:20:00,360 --> 00:20:05,480
+وأحيانًا بتأثر على الماشي، على الجلوس على حركة شلل
+
+185
+00:20:05,480 --> 00:20:10,260
+الأطراف السفلية مثلًا، طبعًا دي أجت من جهة الدماغ
+
+186
+00:20:10,260 --> 00:20:15,060
+من فوق لسه أصعب بكثير ويمكن مايعيشش الجنين يعني،
+
+187
+00:20:15,060 --> 00:20:21,700
+فالـ Folic Acidإذا بتعطيه للمرأة الحامل بتعالج الـ
+
+188
+00:20:21,700 --> 00:20:28,700
+Defect هذا هو صحيح، يعني مش حالة ورافية بحيث إنهم
+
+189
+00:20:28,700 --> 00:20:36,620
+دخلوا ضمن هذه المجموعة بس حتى لو يعني لسبب أو لآخر
+
+190
+00:20:36,620 --> 00:20:43,170
+تم تشقيث أي من هذه الأمراضزي الـ «بيوتينيديز»
+
+191
+00:20:43,170 --> 00:20:47,390
+«بيوتينيديز»، «deficiency»، «بعرف شو بعمل»، «كوبة
+
+192
+00:20:47,390 --> 00:20:51,190
+مالي»، «كوبة الأمين»، «responsive»، «methyl
+
+193
+00:20:51,190 --> 00:20:55,870
+melanoc aciduria» برضه أو «congenital adrenal
+
+194
+00:20:55,870 --> 00:21:00,890
+hyperplasia»، «precoction»، «puberty» و«بتعمل
+
+195
+00:21:00,890 --> 00:21:06,570
+مشاكل»، «phosphoglycerate»،
+
+196
+00:21:06,570 --> 00:21:10,980
+«dehydrogenase deficiency»،اللي هو مطلوب للـ «إل
+
+197
+00:21:10,980 --> 00:21:15,200
+سايرين سينتاسيز» لتعوض الـ «إل سايرين» الـ
+
+198
+00:21:15,200 --> 00:21:22,820
+«Prenatal» فكل هذه أفكار لإذا تمكن الطبيب من تشخيص
+
+199
+00:21:22,820 --> 00:21:29,780
+هذه الأنواع من الأمراض الوراثية وبكون في الغالب
+
+200
+00:21:29,780 --> 00:21:35,240
+يعني صارت عندنا في عائلة تم اكتشاف في هذه الحالة
+
+201
+00:21:35,240 --> 00:21:43,050
+وبعدين تحمل الأممرة ثانية بجنين
+
+202
+00:21:43,050 --> 00:21:52,050
+آخر بيصير الواحد يفكر يعطل مثل اللي كان وياه يعني
+
+203
+00:21:52,050 --> 00:21:57,030
+دلوقتي نحن نتكلم أكثر مجموعة أكثر عن الـ Metabolic
+
+204
+00:21:57,030 --> 00:22:03,510
+Manipulation و Metabolic Diseases يعني هذه حكينا
+
+205
+00:22:03,510 --> 00:22:06,090
+يعني في أجزاء أنواع أشكال
+
+206
+00:22:08,680 --> 00:22:12,520
+متعددة مثل الـ Hemoglobinopathy مثل الـ Neuronal
+
+207
+00:22:12,520 --> 00:22:19,140
+مثل الـ Musculoskeletal مثل الـ Muscles وكذلك، لم
+
+208
+00:22:19,140 --> 00:22:23,100
+نتحدث عن هذه الأشياء نحن هنا على الأشياء اللي فيها
+
+209
+00:22:23,100 --> 00:22:27,680
+خلل بالـ Metabolism بالعمليات الأيض في الخلايا وفي
+
+210
+00:22:27,680 --> 00:22:35,040
+الجسم إذا إنسان عنده G6PD Deficiency في حد عنده
+
+211
+00:22:35,040 --> 00:22:39,780
+سؤال؟ أهإذا حد عندى سؤال، واقفني يا دكتور أحمد
+
+212
+00:22:39,780 --> 00:22:44,800
+وخلّيني أتشوف الـ G6PD Deficiency طبعاً هذا اللي
+
+213
+00:22:44,800 --> 00:22:51,700
+هو مرض التفؤل عبارة عن نقص من الإنزيمات المطلوبة
+
+214
+00:22:51,700 --> 00:23:04,790
+لتعديل وظيفة الإنزيم المسؤول عن بقاء شكلكورية الدم
+
+215
+00:23:04,790 --> 00:23:10,070
+الحمراء بالشكل الطبيعي فإذا بصير عندها G6PD
+
+216
+00:23:10,070 --> 00:23:16,190
+deficiency وهو الإنزين المطلوب للتعامل
+
+217
+00:23:16,190 --> 00:23:20,990
+مع الـ Glucose بالنسبة للـ Red Blood Cells بنتج
+
+218
+00:23:20,990 --> 00:23:26,390
+عنه Susceptibility to Hemolysis with either نفس
+
+219
+00:23:26,390 --> 00:23:32,010
+التعرض للفول، أكل الفول طبعاً الفول الطبيعي، مش
+
+220
+00:23:32,010 --> 00:23:37,520
+مدمسيعني عملية التدميس هذه وعشان نخليه مقبول للأكل
+
+221
+00:23:37,520 --> 00:23:45,020
+لأ بتقلل ويلها علاقة بالـ Antioxidants والأشياء
+
+222
+00:23:45,020 --> 00:23:49,680
+اللي بتكون يعني إلها قدرة على إنه تغير وتخرب
+
+223
+00:23:49,680 --> 00:23:55,060
+الخلايا فدول الناس بيسير بس يعني مثلا ممكن يمر جنب
+
+224
+00:23:55,060 --> 00:24:02,080
+حق الفول أو يمر يأكل فول أو بعض الأدويةمثلًا زي
+
+225
+00:24:02,080 --> 00:24:05,160
+الـ Antimalarial drugs الـ Chloroquine أو الـ
+
+226
+00:24:05,160 --> 00:24:08,240
+Hydroxychloroquine أحيانًا الـ Non-steroidal's
+
+227
+00:24:08,240 --> 00:24:13,080
+أنواع من الأدوية منتجة عنها المرض كله فاللي بيصير
+
+228
+00:24:13,080 --> 00:24:18,500
+أنه مثل هؤلاء الأشخاص ما يجب أنه نعطيه الـ
+
+229
+00:24:18,500 --> 00:24:23,600
+Antimalarial drugs حتى لو احتجناالـ Isoniazide
+
+230
+00:24:23,600 --> 00:24:29,380
+كمان فيه Slow Acetylators فيه مثلا Side Effect لـ
+
+231
+00:24:29,380 --> 00:24:32,880
+Warfarin ممكن أنا إذا بعرف واحد عنده Certain
+
+232
+00:24:32,880 --> 00:24:38,570
+Genetic Mutation مميع الـ Warfarin ممنوع أعطيهاالـ
+
+233
+00:24:38,570 --> 00:24:42,570
+Dietary Restriction أشهر واحد الـPKU اللي هو
+
+234
+00:24:42,570 --> 00:24:45,310
+الـProtein Diet اللي هو الـPhylalanalene Diet،
+
+235
+00:24:45,310 --> 00:24:50,970
+لازم تكون في ناس عندهم Galactosemia ليه
+
+236
+00:24:50,970 --> 00:24:58,790
+الـIncrease in Galactose، ماشي الـGalactosemia،
+
+237
+00:24:58,790 --> 00:25:05,040
+أهالـ .. يعني بدنا نمنع الـ Galactose بدوا الواحد،
+
+238
+00:25:05,040 --> 00:25:09,480
+ماعندي فكرة كثير، مش كيف بتكون بس بدوا الواحد يشوف
+
+239
+00:25:09,480 --> 00:25:15,920
+هذا السكر موجود في أنه مُركّبات، أنه أكلات الـBq
+
+240
+00:25:15,920 --> 00:25:21,780
+بالنسبة للفين على الأنالين يعني هو في غالب
+
+241
+00:25:21,780 --> 00:25:33,130
+البروتيناتمشتقات الأجبان، مشتقات الخبز، الذرة،
+
+242
+00:25:33,130 --> 00:25:39,610
+البطاطا يعني الخبز والذرة، القمح والذرة ممنوعات
+
+243
+00:25:39,610 --> 00:25:46,870
+أظن أن البطاطا مسموحة، الرز مسموح، الرز العادي لأ
+
+244
+00:25:46,870 --> 00:25:50,850
+مش مسموح يعني بتصير أكلات معينة مقبولة وأشياء مش
+
+245
+00:25:50,850 --> 00:25:56,640
+مقبولة، وبدوا الواحد ينتبهدُمن الأكل وين المادة
+
+246
+00:25:56,640 --> 00:26:01,840
+موجودة ولازم يبتعد عنها أحياناً بنسوي عملية
+
+247
+00:26:01,840 --> 00:26:10,860
+replacement زي congenital hypothyroidism هذه بنعطي
+
+248
+00:26:10,860 --> 00:26:15,640
+الـإذا كان جينيتال ومعروف عنها ممكن واحد يعطي الأم
+
+249
+00:26:15,640 --> 00:26:20,300
+إذا بقدر يدخل عليها ما بعرف هنا أما بعد الولادة،
+
+250
+00:26:20,300 --> 00:26:25,780
+إذا الطفل فيه ارثخاء، فيه تأخر في النمو، فيه جفاف،
+
+251
+00:26:25,780 --> 00:26:29,360
+لحتى يعني، و هذا بؤثر على، ليها مرض اسمه
+
+252
+00:26:29,360 --> 00:26:33,980
+«Cretinism» اللي هو يعني Hypothyroidism في
+
+253
+00:26:33,980 --> 00:26:40,350
+الـNeonates وفي الأطفال ويله شكل معين ويكونسهل
+
+254
+00:26:40,350 --> 00:26:45,190
+جدًا علاجه إذا تم تشخيصه مبكر قبل ما يعمل تلف دائم
+
+255
+00:26:45,190 --> 00:26:54,610
+مثل الـ Thyroxine الـ «بيوتينيدناز»
+
+256
+00:26:54,610 --> 00:26:57,770
+الـ «بيوتينيدناز» الـ «بيوتينيدناز» الـ
+
+257
+00:26:57,770 --> 00:26:57,870
+«بيوتينيدناز» الـ «بيوتينيدناز» الـ «بيوتينيدناز»
+
+258
+00:26:57,870 --> 00:26:58,010
+«بيوتينيدناز» الـ «بيوتينيدناز» الـ «بيوتينيدناز»
+
+259
+00:26:58,010 --> 00:27:01,460
+الـ «بيوتينيدناز» الـ «بيوتينيدناز» الـ «الـ Uric
+
+260
+00:27:01,460 --> 00:27:06,520
+Acid Disorders حكينا الـ Sodium Benzoate الفميلة
+
+261
+00:27:06,520 --> 00:27:12,820
+الـ Hypercholesterolemia، الـ heterozygote زي اللي
+
+262
+00:27:12,820 --> 00:27:15,600
+هو الـ drugs that sequester bile acids in the
+
+263
+00:27:15,600 --> 00:27:20,620
+intestine الليبدز
+
+264
+00:27:20,620 --> 00:27:25,100
+الـ Hypercholesterolemia بدأ الـ bile acids عشان
+
+265
+00:27:25,100 --> 00:27:31,560
+يتم انتصاصها فإذا يعني أضعفنا عملية الانتصاصالـ
+
+266
+00:27:31,560 --> 00:27:34,680
+Hypercholesterolemia اللي بتأثر كثير على الشرايين
+
+267
+00:27:34,680 --> 00:27:42,060
+وبتعمل ترسب للدهون وبتعمل تصلب الشرايين، بنوقفها،
+
+268
+00:27:42,060 --> 00:27:48,040
+بنساعد نفس الفكرة لنفس المرض، ممكن نعطي Statins،
+
+269
+00:27:48,040 --> 00:27:57,660
+برضه بتنمع المسبب في تكوين الكوليسترول وزيادة الـ
+
+270
+00:27:57,660 --> 00:28:03,920
+Level تفعفيه الـ Receptor Antagonism «مارفان
+
+271
+00:28:03,920 --> 00:28:07,980
+سندروم» الـ «لو سرطان» Investigational أول مرة
+
+272
+00:28:07,980 --> 00:28:12,260
+بنتبه عليه الـ «لو سرطان» هو الدوة من أدوية الضغط
+
+273
+00:28:12,260 --> 00:28:18,680
+«بال سرطان»، «لو سرطان»، «كاندي سرطان» هدولة
+
+274
+00:28:18,680 --> 00:28:25,460
+مجموعة من أدوية الضغط بتقوم على تثبيت
+
+275
+00:28:29,240 --> 00:28:35,840
+اللي هو الـ ARBs اللي هو Angiotensin Converting
+
+276
+00:28:35,840 --> 00:28:39,780
+Enzyme شبيهة في وظيفة الـ Angiotensin Converting
+
+277
+00:28:39,780 --> 00:28:46,120
+Enzyme Inhibitor فالـ
+
+278
+00:28:46,120 --> 00:28:47,460
+Losartan هذا
+
+279
+00:28:51,830 --> 00:28:58,230
+بقوم بتنزيل الضغط ويرفع الـ «بوتاسيوم» كـ side
+
+280
+00:28:58,230 --> 00:29:02,350
+effect له حقين أنه ممكن يستخدم في الـ Marfan
+
+281
+00:29:02,350 --> 00:29:13,910
+syndrome يعني هذه برضه محاولات لتحسين
+
+282
+00:29:13,910 --> 00:29:15,990
+الوضع هذا أحيانًا
+
+283
+00:29:18,040 --> 00:29:23,140
+يعني إنك انت بالذات اللي عنده «very high level of
+
+284
+00:29:23,140 --> 00:29:28,220
+lipids» بقول زي ما كنت حكيت مرة لما واحد يسحب الدم
+
+285
+00:29:28,220 --> 00:29:35,960
+تبعه بلاقي حليبي يعني مشبع بالدهون درجة عالية جداً
+
+286
+00:29:35,960 --> 00:29:41,860
+وهذا على المدى البعيد خطر جداًفحطين أنه في بعض الـ
+
+287
+00:29:41,860 --> 00:29:47,380
+أتوقع لأي واحد يقول إن هذا علاج تجريبي لـ LDL
+
+288
+00:29:47,380 --> 00:29:52,320
+Aphoresis اللي هي الـ Dialysis أو عملية غسيل الكلا
+
+289
+00:29:52,320 --> 00:29:57,940
+أو غسيل الدم أو كده إن أنا أاخد دم الإنسان هذا
+
+290
+00:29:57,940 --> 00:30:05,910
+وأسحب منه الأشي المضر مثلًاورجع له دمه مع ألبومين
+
+291
+00:30:05,910 --> 00:30:13,950
+سواء العادية أو بحيث أنه يقلل من مستوى الحالة أو
+
+292
+00:30:13,950 --> 00:30:21,090
+المرض يعني أنا أظن أشياء كثيرة هنا الواحد بتعلمها
+
+293
+00:30:21,090 --> 00:30:31,700
+وهذه أمثلة في تفاوت بين قدرات الأدوية هذهوالنقطة
+
+294
+00:30:31,700 --> 00:30:37,420
+اللي ذكرتناها أو يعني حطينا في
+
+295
+00:30:37,420 --> 00:30:43,000
+الـ «جرافات» اللي قبل إنه فيه تطور، فيه تحسن بس
+
+296
+00:30:43,000 --> 00:30:49,120
+أحياناً كثير من الأدوية حتى لما الواحد يجربها وحسب
+
+297
+00:30:49,120 --> 00:30:52,880
+ما بالدراسة بيقول أعطي الدواء لفلاني النسبة
+
+298
+00:30:52,880 --> 00:30:56,620
+الكبيرة منها ممكن للواحد مايلاقي أي استفادة ممكن
+
+299
+00:30:56,620 --> 00:31:03,060
+استفادة بسيطة جداًوالآن كل ما نتحسن أكثر في فهم
+
+300
+00:31:03,060 --> 00:31:06,340
+الأليات
+
+301
+00:31:06,340 --> 00:31:13,660
+للمرض وبالتالي طرق عمل الأدوية وبالتالي نزيد نسبة
+
+302
+00:31:13,660 --> 00:31:19,300
+الأشياء اللي بناقيلها أدوية بشكل عام، فهذه بعض
+
+303
+00:31:19,300 --> 00:31:20,160
+الأمثلة
+
+304
+00:31:25,110 --> 00:31:31,270
+بالنسبة للـ Ammonia بالنسبة للـ Urea Cycle Defect
+
+305
+00:31:31,270 --> 00:31:36,830
+الـ Sodium Benzoate اللي هي يعني إنه الـ Ammonia
+
+306
+00:31:36,830 --> 00:31:44,070
+بشكل يعني في
+
+307
+00:31:44,070 --> 00:31:49,460
+الإنسان الطبيعيالـ Protein Catabolism للـ Amino
+
+308
+00:31:49,460 --> 00:31:59,900
+Acids بدخّل الـ NH3 المشي اللي هو الـ الـ الـ الـ
+
+309
+00:31:59,900 --> 00:32:06,300
+Ammonia اللي هو Toxic ومش كويس وكذا الأصل أن تروح
+
+310
+00:32:06,300 --> 00:32:08,820
+إشي اسمه الـ Urea Cycle بحيث أنه بيطلع عند الـ
+
+311
+00:32:08,820 --> 00:32:15,680
+Urea اللي بيطلع في الـ Bowl فهذا بسببيعني مشاكل
+
+312
+00:32:15,680 --> 00:32:21,500
+ممكن يعمل أظنّي stones ممكن يعمل mental problem
+
+313
+00:32:21,500 --> 00:32:26,200
+ممكن يأثر على أشياء أخرى ماشوفتش حالات ما بعرف
+
+314
+00:32:26,200 --> 00:32:33,160
+عنها ففيه عنا إشي اسمه Uricicle defect أو enzymes
+
+315
+00:32:33,160 --> 00:32:38,340
+أو problems فإذا أعطيت حاجة اسمها Sodium Benzoate
+
+316
+00:32:39,050 --> 00:32:46,690
+سيحول مع الـGlycine والبنزوات الـUrea أسف الأمونيا
+
+317
+00:32:46,690 --> 00:32:53,110
+ستتحول لهيبيوريت الهيبيوريت هذا شغلي ممكن تخرج في
+
+318
+00:32:53,110 --> 00:32:59,950
+الـBowlفبالتالي أنا أخفف المرض وأمنع مشاكله وأجد
+
+319
+00:32:59,950 --> 00:33:07,030
+آلية أخرى للجسم وللـ «cell cycle» أو للجسم أنه
+
+320
+00:33:07,030 --> 00:33:12,150
+يخلص من الـ«product» الـ«toxic» الـ«product» اللي
+
+321
+00:33:12,150 --> 00:33:17,070
+بيكون «very high» بالنسبة لما يكون المرض موجود
+
+322
+00:33:17,070 --> 00:33:23,620
+ماشي، فهذا مثال على شيء نستفيد منهبالنسبة
+
+323
+00:33:23,620 --> 00:33:28,780
+للـFamilial Hypercholesterolemia Heterozygous شكله
+
+324
+00:33:28,780 --> 00:33:32,920
+الـHomozygous بيكون شديد كثير وما بعيشش أو كده أو
+
+325
+00:33:32,920 --> 00:33:36,280
+هيك فمن
+
+326
+00:33:36,280 --> 00:33:38,740
+ناحية الأمراض هذه اللي هو الـFamilial
+
+327
+00:33:38,740 --> 00:33:45,940
+Hypercholesterolemia الـHeterozygous بعد ما يعني
+
+328
+00:33:45,940 --> 00:33:56,210
+الـLDL Low Density Lipoproteinبتم أخذه بخلايا
+
+329
+00:33:56,210 --> 00:34:06,910
+الكبت ناشي مع الـ HMG هذا اللي هو الـ product تبع
+
+330
+00:34:06,910 --> 00:34:18,380
+اللي هويعني المادة مع الـ Coenzyme A بيكون الـ LDL
+
+331
+00:34:18,380 --> 00:34:22,940
+والمادة هذه بتحول له كوليسترول بيتم برضه إفرازه
+
+332
+00:34:22,940 --> 00:34:29,020
+ضمن الـ Bile Acid وبرجع مرة ثانية بدخل في الجسم
+
+333
+00:34:29,020 --> 00:34:35,180
+وبعدين محمول على LDL أو الكوليسترول بالذات الـ Low
+
+334
+00:34:35,180 --> 00:34:39,260
+Density اللي هو الكوليسترول السيء الـ High Density
+
+335
+00:34:39,260 --> 00:34:43,930
+Lipoproteinالـ high-density lipoprotein لأ، كويس
+
+336
+00:34:43,930 --> 00:34:47,550
+وعلى أكس، protective لو زاد، ما في مشكلة إذا كانت
+
+337
+00:34:47,550 --> 00:34:54,990
+زيادة منه فإذا أنت أعطيت دوة أو شيء بيمنع انتصاص
+
+338
+00:34:54,990 --> 00:35:00,930
+الـ bile acid وهي الشيء المطلوب حتى يتم انتصاص الـ
+
+339
+00:35:00,930 --> 00:35:05,350
+lipids بشكل عام الكوليسترول، الـ triglycerides الـ
+
+340
+00:35:05,350 --> 00:35:09,970
+fatty acids، أي شيء من هذا النوع بحاجة للواحد لـ
+
+341
+00:35:10,320 --> 00:35:17,660
+بيل أسد حتى يتم الـ absorption فإذا أنا أعطيت شيء
+
+342
+00:35:17,660 --> 00:35:24,160
+يوقف الـ absorption بقلل الـ LDL اللي بوجود في
+
+343
+00:35:24,160 --> 00:35:31,980
+الجسم وإذا حطيت برضه product that inhibit الـ
+
+344
+00:35:31,980 --> 00:35:36,180
+enzyme اللي بتأدى لتقليل الـ synthesis برضه
+
+345
+00:35:36,180 --> 00:35:43,160
+للكوليسترول في حالة ما يكون شديد كثيربرضه بتكون
+
+346
+00:35:43,160 --> 00:35:48,400
+آلية أخرى يعني فأحياناً نحتاج أنه ننزل الـ LDL
+
+347
+00:35:48,400 --> 00:35:56,920
+وهذه أمثلة على نتيجة فهمنا للـ «ميكانيزم»
+
+348
+00:35:56,920 --> 00:36:01,980
+والـ «ميتابوليزم» والأشياء هذه وكيف أنا أتدخل،
+
+349
+00:36:01,980 --> 00:36:06,160
+فإذا فيه «فميليلهايبركولستريميكهيتروزايجس» الـ
+
+350
+00:36:06,160 --> 00:36:12,110
+«hyperlipidemia» من هذا النوع الفميليلولو دخل بالـ
+
+351
+00:36:12,110 --> 00:36:21,970
+Premature Death وولو دخل بإنه يكون فيه مشكلة هنا
+
+352
+00:36:21,970 --> 00:36:29,650
+نتكلم عن الـ Marfan Syndrome برضه حكينا على إن الـ
+
+353
+00:36:29,650 --> 00:36:34,210
+«لو سرطان» بيحاولوا إنه يستفيدوا منه حتى يعالجوا
+
+354
+00:36:34,210 --> 00:36:37,710
+هذه الحالة ويعني
+
+355
+00:36:38,320 --> 00:36:46,800
+أول مرة بنتبه عليها وماعندي خبرة كبيرة فيها مارفان
+
+356
+00:36:46,800 --> 00:36:52,440
+سندروم بالأخر كلها Problem جينية بيصير خلل في
+
+357
+00:36:52,440 --> 00:36:58,360
+المادة والنسيج الضام فبصير صحيح الإنسان بيطلع طويل
+
+358
+00:36:58,360 --> 00:37:04,620
+كثير بس معرض إنه يصير عنده Subluxation يعني
+
+359
+00:37:04,620 --> 00:37:11,520
+الأطراف مرنة كثيربصير الـ High-arch palate بصير
+
+360
+00:37:11,520 --> 00:37:15,880
+الـ Lens dislocation إلى العيون و الـ Congenital
+
+361
+00:37:15,880 --> 00:37:22,380
+يعني أو الـ Aortic aneurysm الـ Dilatation of the
+
+362
+00:37:22,380 --> 00:37:28,560
+abdominal aorta كل هذه مظاهر و شكله أنه يعني هذا
+
+363
+00:37:28,560 --> 00:37:34,240
+من استخدامات هذه الأدوية في يعني بقالية معينة يعني
+
+364
+00:37:36,890 --> 00:37:45,350
+الاستخدام هنا يعني حسب اللي يعني بدل واحد يكون
+
+365
+00:37:45,350 --> 00:37:54,270
+يأخذ أحدث معلومة على أحدث شيء متفق عليه يعني
+
+366
+00:37:54,270 --> 00:38:04,610
+الأدوية من الأنواع الثانيةماشي، بالنسبة
+
+367
+00:38:04,610 --> 00:38:12,170
+لـ… يعني زي
+
+368
+00:38:12,170 --> 00:38:23,790
+ما في عندنا فهم أكبر لخطوات تنشيط أي protein معين
+
+369
+00:38:23,790 --> 00:38:33,880
+يعني دايماً نتكلمعن يعني غير الـ «Coding DNA» تبع
+
+370
+00:38:33,880 --> 00:38:37,920
+الـ «جين» تبع الـ «بروتين» المعين اللي نتكلم عنه
+
+371
+00:38:37,920 --> 00:38:46,200
+أحيانًا يعني من خلال فهم خلق الإنسان من خلال فهمنا
+
+372
+00:38:46,200 --> 00:38:50,920
+شو العوامل اللي بتخلي في الخلية هذه هذا الـ «جين»
+
+373
+00:38:50,920 --> 00:38:55,960
+يشتغلففي الغالب راح يكون يعني اللي هو بيسموهم زي
+
+374
+00:38:55,960 --> 00:39:03,640
+Growth Factors يعني Signal
+
+375
+00:39:03,640 --> 00:39:09,840
+Transduction Mechanisms لتنشيط مواقع معينة في الـ
+
+376
+00:39:09,840 --> 00:39:18,120
+DNAفلما يعرف الواحد الأليات هذه ممكن يحسن قضية
+
+377
+00:39:18,120 --> 00:39:23,840
+علاجها بشكل متخصص على إنه الأشياء اللي بدنا هي
+
+378
+00:39:23,840 --> 00:39:29,740
+سواء نرغب إنه نزيد أو نقصه حسب المرض أو حسب الحالة
+
+379
+00:39:29,740 --> 00:39:35,800
+يعني إذا كان المنتج هوالبروتين الفاسد المسبب للمرض
+
+380
+00:39:35,800 --> 00:39:41,440
+بدي لو فيه أقدر إنه المنشط لهذا البروتين أسكره
+
+381
+00:39:41,440 --> 00:39:49,440
+بكون خلصت المريض من هذا البروتين السيء يعني ففيه،
+
+382
+00:39:49,440 --> 00:39:54,660
+إذا بننتبه في حالة اسمها Hereditary Angioneurotic
+
+383
+00:39:54,660 --> 00:39:59,400
+Edema أو Hereditary Angioedema هذا من الأمراض اللي
+
+384
+00:39:59,400 --> 00:40:07,820
+أنا بتعامل معهامرض نادر جداً عبارة عن حالة الإنسان
+
+385
+00:40:07,820 --> 00:40:14,340
+بيصير يطلع عليه يعني وثمات وعائية زي ما بيقول
+
+386
+00:40:14,340 --> 00:40:19,520
+بالإنجليزي Angioedema من الأمراض الشائعة جداً
+
+387
+00:40:19,520 --> 00:40:24,380
+الناس بيصير عندهم Eurticaria Angioedema Eurticaria
+
+388
+00:40:24,380 --> 00:40:32,630
+اللي هي حالةيعني إن الإنسان بيكون عليه زي جارس
+
+389
+00:40:32,630 --> 00:40:39,850
+البعوض طفح مزعج بسبب الحكة زي جارس البعوض هذا
+
+390
+00:40:39,850 --> 00:40:44,490
+بنسميها «يورتيكاريا» الـ «يورتيكاريا» شائعة جدا
+
+391
+00:40:44,490 --> 00:40:50,160
+ويلها أسباب كثيرةتحسوس ومرات أمراض كبد أو أمراض
+
+392
+00:40:50,160 --> 00:40:55,480
+غضب درقية أو أمراض كلاب أو أمراض طفيليات أو
+
+393
+00:40:55,480 --> 00:40:59,560
+Parasitic Infection تعمل حساسي كذا، بس فيه نوعية
+
+394
+00:40:59,560 --> 00:41:07,400
+محددة عبارة عن حالة ورافية تزامل Dominant، وفيها
+
+395
+00:41:07,400 --> 00:41:14,370
+أكثر من نوعإنه فيه بروتين ضروري في الجسم اسمه «C1
+
+396
+00:41:14,370 --> 00:41:19,890
+Stress Inhibitor» اللي أخدته في الـ«إميونولوجيا»
+
+397
+00:41:19,890 --> 00:41:26,690
+تأثير أنه في عندي إنزايم مطلوب في الجسم اسمه «C1
+
+398
+00:41:26,690 --> 00:41:33,370
+Stress» يعني محطم الـ«C1» من مراكبات الـComplement
+
+399
+00:41:34,240 --> 00:41:40,400
+فهذا مرض النوعي الأساسي منه لأنه فيه أكتر من النوع
+
+400
+00:41:40,400 --> 00:41:45,120
+بيكون autosomal dominant المرضى بيجوا بأنجو ديما
+
+401
+00:41:45,120 --> 00:41:49,200
+بس، بيجوا بورم يعني بتلاقي إيديه بتورم، وجهه
+
+402
+00:41:49,200 --> 00:41:56,880
+بتورم، كذا، بيكون هذا المرض يعني بالذات التورمات
+
+403
+00:41:56,880 --> 00:42:01,130
+بتيجي على محلات الضرباتيعني أنا باتلاقين إلى أي
+
+404
+00:42:01,130 --> 00:42:06,270
+إنسان بشتكي من شري ووذمة وكذا بسأله هو ولا من أهله
+
+405
+00:42:06,270 --> 00:42:12,750
+أي واحد تكده صحله ضربة بورا مكانها هي بتكون مع C1
+
+406
+00:42:12,750 --> 00:42:20,870
+Stress Inhibitor فمن علاجات الـ Hereditary
+
+407
+00:42:20,870 --> 00:42:27,560
+Angioedema إذا ثبتتيعني بيكون الـ «C1» stress
+
+408
+00:42:27,560 --> 00:42:32,440
+level low بصراحة في عندنا دوة اسمها الـ «دانازول»
+
+409
+00:42:32,440 --> 00:42:37,480
+وفي بديل عنه طالع أجدد وأغلى شوية الـ «دانازول»
+
+410
+00:42:37,480 --> 00:42:43,740
+اللي هو نوع من قريب الـ«هرمون» الـ«سيكس هرمون»
+
+411
+00:42:43,740 --> 00:42:48,460
+الـreplacement أو كده بيلاحظوا أنه بس تحت المريض
+
+412
+00:42:48,460 --> 00:42:54,590
+النوبات هذه بتخف فالفكرةإنه زي ما انتوا شايفين في
+
+413
+00:42:54,590 --> 00:43:02,230
+الجدول الأول هو إنه الجين
+
+414
+00:43:02,230 --> 00:43:06,130
+المطلوب له زي «C1 Stress Inhibitor» في هذه الحالة
+
+415
+00:43:06,130 --> 00:43:13,930
+مثلا الـ «بروموتر ريجين» أنا يعني إذا كان هنا
+
+416
+00:43:13,930 --> 00:43:18,590
+المرض إنه مثلا بشتغلش ممكن أنا أحط إشي يخلّيه
+
+417
+00:43:18,590 --> 00:43:22,800
+يشتغل وأكون أثبت إنه بخلّيه يشتغلأو إذا كان هذا
+
+418
+00:43:22,800 --> 00:43:29,860
+مضرر وهو اللي عامل المرض باعطيه شيء يسوي له تسكير
+
+419
+00:43:29,860 --> 00:43:36,040
+عليه يعني
+
+420
+00:43:36,040 --> 00:43:41,480
+هذا مثال على شيءيعني نستخدمه سريريا وموجود
+
+421
+00:43:41,480 --> 00:43:49,260
+وبستخدمه وجربته وأنا شخصيا عندنا في الأردن هذا
+
+422
+00:43:49,260 --> 00:43:53,720
+الدواء موجود فقط بالخدمات الطبية الملكية وكل ما
+
+423
+00:43:53,720 --> 00:43:58,640
+أشخص حالي بهذه الطريقة يعني هم عدد قليل اللي
+
+424
+00:43:58,640 --> 00:44:04,760
+بشخصهم وفي الغالب مافيش تاريخ عائليويكون الإنسان
+
+425
+00:44:04,760 --> 00:44:08,360
+المصاب هو اللي صارت عنده الطفرة وهو أول واحد بيّن
+
+426
+00:44:08,360 --> 00:44:12,100
+عنده المرض يعني هذا اللي في الغالب بيكون هيك
+
+427
+00:44:12,100 --> 00:44:16,180
+فبوديهم على الخدمات وبيبعطوهم الدنازول وبتكون
+
+428
+00:44:16,180 --> 00:44:20,560
+أمرهم أهداً وهذا بيسوي Increase gene expression
+
+429
+00:44:20,560 --> 00:44:25,580
+from the wild type locus أو from mutant locus with
+
+430
+00:44:25,580 --> 00:44:31,940
+residual function يعني هي طريقة العمل هناإذا عندي
+
+431
+00:44:31,940 --> 00:44:38,320
+أنا يعني النظريات كيف هذا الدواء بيشتغل إنه «it is
+
+432
+00:44:38,320 --> 00:44:42,600
+almost dominant» يعني واحدة مصابة وواحدة طبيعية
+
+433
+00:44:42,600 --> 00:44:47,740
+وبيّن عنده المرض لأنه «dominant» فأحياناً لما أنا
+
+434
+00:44:47,740 --> 00:44:52,700
+أعطي الدواء هذا إذا بقى ليه معينة والمشكلة بتكون
+
+435
+00:44:52,700 --> 00:44:58,580
+في نقص الانزيم المطلوب بتلاقيها بتزوده أو بتقلل
+
+436
+00:44:58,580 --> 00:45:05,520
+المصابأو بتزيد حتى مستوى الـ يعني بتحسن مستوى
+
+437
+00:45:05,520 --> 00:45:10,680
+الوظيفة المطلوبة فيه اللي هو الـ DNA methylation
+
+438
+00:45:10,680 --> 00:45:20,960
+therapy with the ديستابين هذا الدواء يعني يمكن في
+
+439
+00:45:20,960 --> 00:45:24,750
+حالات معينة من الـ Sickle Cell Diseaseيعني إذا
+
+440
+00:45:24,750 --> 00:45:30,510
+بتذكروا الـ Sickle Cell اللي هو بالذات يعني لما
+
+441
+00:45:30,510 --> 00:45:39,370
+يكون فيه مشاكل جزء مهم من تحديد درجة الإصابة في
+
+442
+00:45:39,370 --> 00:45:44,690
+الـ Sickle Cell بتكون مستوى الـ Hemoglobin F الـ
+
+443
+00:45:44,690 --> 00:45:50,870
+Hemoglobin F، سبحان الله، إذا ظهر موجود يعني أنت
+
+444
+00:45:50,870 --> 00:45:57,850
+الـفي الغالب الإنسان بيقولوله SA يعني الـ
+
+445
+00:45:57,850 --> 00:46:04,690
+Hemoglobin تبعه اللي عنده … اللي إذا كان مصاب SS،
+
+446
+00:46:04,690 --> 00:46:10,070
+Sickle Cell Disease، ماشي؟ فيه Sickle Cell Carrier
+
+447
+00:46:10,070 --> 00:46:16,590
+SA، حتى المصابين لما نيجي نعمل حتى Protein
+
+448
+00:46:16,590 --> 00:46:20,910
+Electrophoresis أو Hemoglobin Electrophoresis
+
+449
+00:46:21,370 --> 00:46:25,910
+بنلاقي ممكن يعني لأنه في فترة في حياة الإنسان كان
+
+450
+00:46:25,910 --> 00:46:29,350
+عنده Hemoglobin-F مش الـHemoglobin من هذا النوع
+
+451
+00:46:29,350 --> 00:46:38,110
+فالملاحظ أنه لو إنسان ضال عنده إنتاج للـHemoglobin
+
+452
+00:46:38,110 --> 00:46:45,130
+-F نسبة أكبر بيصير المرض أخف والسبب أنه كل ما
+
+453
+00:46:45,130 --> 00:46:51,630
+ارتفع كمية الـHemoglobin-Fفي خلايا الدم الحمراء
+
+454
+00:46:51,630 --> 00:46:56,350
+الـ Cycling Phenomena بتقل ما بتحدث بنفس الطريقة
+
+455
+00:46:56,350 --> 00:47:02,050
+فبالتالي إذا حطينا
+
+456
+00:47:02,050 --> 00:47:09,510
+إشي بقالية معينة يعني زودنا نسبة الـ Hemoglobin F
+
+457
+00:47:09,510 --> 00:47:14,770
+طبعاً بدي يكون Hemoglobin F في جوا خلايا الدم
+
+458
+00:47:14,770 --> 00:47:22,740
+الحمراء يعنيلازم نتدخّل أو بقالية معينة نصل إلى
+
+459
+00:47:22,740 --> 00:47:27,720
+نفس الخلايا المصابة ونحاول أن نغيّر فيها الـ
+
+460
+00:47:27,720 --> 00:47:31,520
+Hemoglobinopathies والـ Sickle Cells وكذا بشكل
+
+461
+00:47:31,520 --> 00:47:36,100
+عام، يعني بالذات إذا كان مكان متقدم الطب فيه
+
+462
+00:47:36,100 --> 00:47:44,540
+وبالذات إذا شخصوا الحالة مبكراً وتم يعني
+
+463
+00:47:46,870 --> 00:47:50,710
+بالتفكير والتدخل، إذا كان هناك خبرة أو إمكانات أو
+
+464
+00:47:50,710 --> 00:47:58,060
+شيء آخر قبل أن يُعطى الإنسان نقل دم بشكل كبيريعني
+
+465
+00:47:58,060 --> 00:48:03,620
+أول علاج سريع لما بتكون فيه أزمة و Crisis ومشاكل
+
+466
+00:48:03,620 --> 00:48:10,480
+أنه نعطي دم بيحسن المريض عرضياً بشكل أعراضه يعني
+
+467
+00:48:10,480 --> 00:48:13,960
+الـ Anime بيخففها الـ Sickle Cell Episode بيخففه
+
+468
+00:48:13,960 --> 00:48:20,320
+بيعمل تحسين للمريض يعني فالنقل
+
+469
+00:48:20,320 --> 00:48:24,700
+للمخاع العظم ماشي للـ Thalassemia أو الـ
+
+470
+00:48:24,700 --> 00:48:30,730
+Hemoglobinopathiesواللي راح ناخد بعد شوية اللي هم
+
+471
+00:48:30,730 --> 00:48:36,770
+الأمراض نقصان المناعة الأولية الـ Primary Immune
+
+472
+00:48:36,770 --> 00:48:40,330
+Deficiencies زي الـ Severe Combined Immune
+
+473
+00:48:40,330 --> 00:48:45,950
+Deficiency، الـ SCID هدولة إذا الواحد بقدر يعمل
+
+474
+00:48:45,950 --> 00:48:49,250
+Boomer Transplantation أو تمثل Transplantation من
+
+475
+00:48:49,250 --> 00:48:56,800
+إنسان قريب بكون كويس، بس أحيانًا إذا تمإعطاء يعني
+
+476
+00:48:56,800 --> 00:49:01,620
+لما يكون فيه نقفة منع عادة ما في مشكلة ما بنفش
+
+477
+00:49:01,620 --> 00:49:05,000
+داعي لدمة أو لا شيء محدد من قبل زاد إنه نفس
+
+478
+00:49:05,000 --> 00:49:09,500
+الإنسان منعته بعيفة ما بتخليه يقدر يرفض العضو اللي
+
+479
+00:49:09,500 --> 00:49:12,520
+ماعطيه له، مش عارف؟ بس بالنسبة
+
+480
+00:49:12,520 --> 00:49:17,260
+للـHemoglobinopathies إذا تم إعطاء الدم مرات كثيرة
+
+481
+00:49:17,260 --> 00:49:23,360
+إلا كل مرة بكون في بعض خلايا الدم البيضاء أو بعض
+
+482
+00:49:23,360 --> 00:49:31,780
+الـAntigensزي مثال مثلًا حتى لو بشكل نادر للـRare
+
+483
+00:49:31,780 --> 00:49:37,840
+Blood Groups كأنه أعطانا إنسان زي ما بنعطي زي ما
+
+484
+00:49:37,840 --> 00:49:42,120
+يحصل مع المرأة الحامل بالـRH Incompatibility إنه
+
+485
+00:49:42,120 --> 00:49:47,240
+يكون الجنين
+
+486
+00:49:47,240 --> 00:49:51,890
+الأول اللي أتلقاه Positiveبيكون الجنين الأول
+
+487
+00:49:51,890 --> 00:49:55,510
+بيعدّي وما فيش مشكلة بس بعدين لما يصير
+
+488
+00:49:55,510 --> 00:49:59,850
+الـSensitization ما بيظل الجنين الثالث أو الرابع
+
+489
+00:49:59,850 --> 00:50:10,910
+بيصير تجهد كل ما يتم حمل يعني فالفكرة أنه إذا بدنا
+
+490
+00:50:10,910 --> 00:50:16,930
+نقل نقاع عضم لزي هذه المشكلة اللي هي الـHemoglobin
+
+491
+00:50:16,930 --> 00:50:22,070
+Abortaseلازم يعمل بشكل مبكر لازم يعمل قبل ما يُعطى
+
+492
+00:50:22,070 --> 00:50:27,530
+المريض عدد كبير من نقل الدم ويقال عليه عملية
+
+493
+00:50:27,530 --> 00:50:31,890
+الـUnlaw Immunization بيصير المناعة منشطة كثير
+
+494
+00:50:31,890 --> 00:50:37,050
+بحيث أنها ترفض نقل الدم وبالتالي تصير مشاكل فبديل
+
+495
+00:50:37,050 --> 00:50:41,450
+آخر لما ما يكون عنده إمكانية لهذا النوع العلاج
+
+496
+00:50:41,450 --> 00:50:49,340
+الأكثر أنه أنا أعدل درجة الـDNA methylationمع دوة
+
+497
+00:50:49,340 --> 00:50:53,040
+مثل ديستابين
+
+498
+00:50:53,040 --> 00:50:58,380
+لزيادة الـ hemoglobin F اللي بيحسن الـ Sickle Cell
+
+499
+00:50:58,380 --> 00:51:05,900
+على الأقل مظهريًامع اللي إذا بننتبه للسهم الرابع
+
+500
+00:51:05,900 --> 00:51:10,640
+اللي هو الـ Gene Therapy زي الـ X-Linked Severe
+
+501
+00:51:10,640 --> 00:51:13,760
+Combined Immune Deficiency زي اللي هو الـ
+
+502
+00:51:13,760 --> 00:51:18,960
+Adenosine Deaminase Deficiency أحيانًا إذا في نقص
+
+503
+00:51:18,960 --> 00:51:26,700
+إنزين معين بالذات في قضية نقل النخاع العظم فهو من
+
+504
+00:51:26,700 --> 00:51:35,620
+ناحيةتقنية من ناحية procedure خفيف وبسيط وسهل جداً
+
+505
+00:51:35,620 --> 00:51:41,200
+يعني ما بدوش تعقيدات كثيرة يعني ينقل في جسم المصاب
+
+506
+00:51:41,200 --> 00:51:45,680
+عن طريق نقل الدم يعني هيك زي نقل الدم لما أنقل أنا
+
+507
+00:51:45,680 --> 00:51:52,640
+نخاع عظم نخاع العظم من المتبرع بنيجي وبنخدره
+
+508
+00:51:52,640 --> 00:51:57,540
+وبنيجي على العظام الكبيرة فيه عظام الحوض مثلاً
+
+509
+00:51:57,910 --> 00:52:04,690
+بالذات بإبر كبير كثير مرات كثيرة بنسحب نقاء العظم
+
+510
+00:52:04,690 --> 00:52:08,550
+من الإنسان الطبيعي فبتطلع لنا كمية بتكون شبيهة
+
+511
+00:52:08,550 --> 00:52:14,510
+بوحدة الدم بحيث إنه نقلها للإنسان المصاب بكون عن
+
+512
+00:52:14,510 --> 00:52:20,490
+طريق نقل دم عادي والخلايا الجذعية والخلايا النقاء
+
+513
+00:52:20,490 --> 00:52:24,370
+العظم بتعرف تندل ترجع عن طريق الدم لنقاء العظم
+
+514
+00:52:24,370 --> 00:52:24,850
+تبعها
+
+515
+00:52:30,600 --> 00:52:39,060
+ففي أليات أخرى زي إنه نعطي Small Inactive RNA
+
+516
+00:52:39,060 --> 00:52:45,980
+Segments يعني عبارة عن إن أنا أعطي
+
+517
+00:52:45,980 --> 00:52:56,430
+إشي يؤثر على إنه يخرّب أو يقلل الـMessenger RNAكل
+
+518
+00:52:56,430 --> 00:53:03,210
+المشاكل اللي يعني بذكر مرة ثانية يعني في بعض
+
+519
+00:53:03,210 --> 00:53:09,230
+الأشياء أنا عندي خبرة فيها شوية ويعني راح نتفرج
+
+520
+00:53:09,230 --> 00:53:13,550
+على كثير من الأشياء بعدين بحطولك أنثى على إنه
+
+521
+00:53:13,550 --> 00:53:18,170
+تجربة قام وبيعملها وكانت النتيجة نص نص، كويسة
+
+522
+00:53:18,170 --> 00:53:22,710
+كثير، كويسة بشكل واضح، كده وتلاقي شغلات عبارة عن
+
+523
+00:53:22,710 --> 00:53:27,920
+عمليات دراسيةالـ «Messenger RNA» جوا الخلية صعب أن
+
+524
+00:53:27,920 --> 00:53:35,300
+الواحد يغيره وكانت تعطي حتى لو ما بستطيعش أني مثلا
+
+525
+00:53:35,300 --> 00:53:41,500
+أجيب حب الدواء المريض يأخذه أو حتى إذا إشي صعب أنه
+
+526
+00:53:41,500 --> 00:53:47,740
+يكون عن طريق الفم حتى عن طريق الوريد لو دخلته جوا
+
+527
+00:53:47,740 --> 00:53:57,340
+الجسم بشكل حقن أو بالوريدليس بالضرورة إنه يكون
+
+528
+00:53:57,340 --> 00:54:04,600
+مفيد إنه بدّك الدواء هذا يصل جوا الخلايا لحيث إنه
+
+529
+00:54:04,600 --> 00:54:10,700
+يعني أو بالذات إذا الـMolecule كبير وComplex وكذا
+
+530
+00:54:10,700 --> 00:54:18,520
+الجسم بحكمه وما بسمحله يدخل جوا الخلية فقضية
+
+531
+00:54:18,520 --> 00:54:25,570
+زي الـTrans Tyreneالـ Trans-thyretine في الـ
+
+532
+00:54:25,570 --> 00:54:34,390
+Amyloidosis يعني نوع من استخدام الـ RNA لتعديل على
+
+533
+00:54:34,390 --> 00:54:37,550
+مستوى الـ expression أو الـ function of the
+
+534
+00:54:37,550 --> 00:54:43,930
+messenger RNA أحياناً في
+
+535
+00:54:43,930 --> 00:54:52,820
+بعض الأدوية لأنه لما يكون عندي أنا جزء من الـالـ
+
+536
+00:54:52,820 --> 00:54:58,800
+Pathology جزء من تسبب المرض أنه الـ يعني زي ما
+
+537
+00:54:58,800 --> 00:55:03,220
+تقوله مثلاً كيف الفرق بين الـ الـ Hemoglobin
+
+538
+00:55:03,220 --> 00:55:06,540
+العادى الـ Beta Chain والـ Cycling الـ Beta Chain
+
+539
+00:55:06,540 --> 00:55:11,200
+في حالة الـ Sickle Cell Disease أنه الـ Sickle
+
+540
+00:55:11,200 --> 00:55:17,160
+Cell Disease الـ Mutant Protein الـ Abnormal
+
+541
+00:55:17,160 --> 00:55:21,960
+Protein فيه قلوب ميزة بتخليه ما يشتغلش مظبوط
+
+542
+00:55:23,250 --> 00:55:26,990
+فمثلًا، إيشي مكان المفروض يكون مفتوح، صار عندي
+
+543
+00:55:26,990 --> 00:55:32,650
+folding بطريقة مختلفة وسكر، فإذا عندي دوة أو شيء
+
+544
+00:55:32,650 --> 00:55:39,010
+بقدر أخلي المكان المفتوح يظل مفتوح وما يسكرش، ممكن
+
+545
+00:55:39,010 --> 00:55:50,750
+هذايكون مفيد يعني فهذا فيه دوة «Luma Saptor» «Luma
+
+546
+00:55:50,750 --> 00:55:56,690
+Saptor» اللي هو «Stabilizes Reformed» اللي هو
+
+547
+00:55:56,690 --> 00:56:05,210
+«Delta F508» في مرض معين يعني فهي كلها أمثل إلى
+
+548
+00:56:05,210 --> 00:56:10,090
+أدوي وأشياءالـ Cystic Fibrosis وهنا أحنا، يعني
+
+549
+00:56:10,090 --> 00:56:12,550
+يمكن هيك كثير من الأمثلة بتيجي على الـ Cystic
+
+550
+00:56:12,550 --> 00:56:17,350
+Fibrosis الممكن
+
+551
+00:56:17,350 --> 00:56:22,850
+أنا يعني أعطي أدوية تساعد الـ Protein Replacement
+
+552
+00:56:22,850 --> 00:56:26,950
+يعني بعد ما نوصل يعني ممكن الـ Folding ممكن أنا
+
+553
+00:56:26,950 --> 00:56:33,570
+أعطي شيء يـMaintain it البروتين اللي اتكون هذا
+
+554
+00:56:33,570 --> 00:56:37,930
+أحياناًبكون معقد وفي أشياء كثيرة وانا مثال على
+
+555
+00:56:37,930 --> 00:56:42,470
+«سيستيكفايبروسيس» «Systic Fibrosis Transporter
+
+556
+00:56:42,470 --> 00:56:50,870
+Receptor» وهو نقله أكثر من الـ «domain» وعبارة عن
+
+557
+00:56:50,870 --> 00:56:57,230
+«gate» للـ «onion exchange» فبالتالي، إذا أنا
+
+558
+00:56:57,230 --> 00:57:07,290
+قلاقي أدويةبتحسن وظيفة الـ Protein هذا ممكن أنا
+
+559
+00:57:07,290 --> 00:57:12,550
+مرض زي الـ Cystic Fibrosis أحسنه الفيموفيليا بيكون
+
+560
+00:57:12,550 --> 00:57:15,290
+إنه أنا بعمل protein replacement with native
+
+561
+00:57:15,290 --> 00:57:21,370
+protein زي هنا أو إنه الـ Goucher Disease أو
+
+562
+00:57:21,370 --> 00:57:25,500
+Fabric Disease من الـ Metabolicيعني الـ Diseases
+
+563
+00:57:25,500 --> 00:57:30,340
+الـ ERT برضه ممكن أنا أعطيه بروتيل مرات مع أنه
+
+564
+00:57:30,340 --> 00:57:34,780
+المفروض يشتغل جوا خلايا بس إذا بيعطيه بالدم ممكن
+
+565
+00:57:34,780 --> 00:57:40,540
+أحيانًا أحسن المرض يعني بالحالة هذه أحيانًا بنسوي
+
+566
+00:57:40,540 --> 00:57:45,380
+الـ Replacement بـ Modified Protein ماشي الـ
+
+567
+00:57:45,380 --> 00:57:53,290
+Regulation يعني الـ Big هذه نسيت اختصار لإيشفي
+
+568
+00:57:53,290 --> 00:57:58,830
+أحيانًا أدوية وحالات
+
+569
+00:57:58,830 --> 00:58:05,870
+مثلًا في الكثير مثلًا الإتهاب الكبد والوباء الـ C
+
+570
+00:58:05,870 --> 00:58:11,730
+الهي بتاعة الـ C فيروس وإلا عندي أنا مثلًا chronic
+
+571
+00:58:11,730 --> 00:58:15,590
+granulomatous disease أوفي حالات عندي زي الـ
+
+572
+00:58:15,590 --> 00:58:20,550
+Anchor Cell Deficiency «طبيعي خطر الخطر» في من
+
+573
+00:58:20,550 --> 00:58:26,250
+الأدوية دواب عبارة عن هرمون في المناعة تفرز الجسم
+
+574
+00:58:26,250 --> 00:58:29,150
+في مرحلة معينة في مقاومة الفيروسات اسمه الـ
+
+575
+00:58:29,150 --> 00:58:35,830
+Interferon فالـ Interferon الطبيعي
+
+576
+00:58:35,830 --> 00:58:39,890
+اللي أول ما صنعوه لما
+
+577
+00:58:42,220 --> 00:58:46,720
+بأعطيه في جسم الإنسان بأعطيه حقنة للإنسان هذا
+
+578
+00:58:46,720 --> 00:58:53,300
+ميزته صحيح، مؤثر و بـFeel بس برتفع كثير و بختفي
+
+579
+00:58:53,300 --> 00:58:57,800
+بسرعة فبتم يعني الـ «metabolism» و الـ «half-life»
+
+580
+00:58:57,800 --> 00:59:04,620
+تبع الدراج أو تبع الهرمون هذا سريع كثير فعملية الـ
+
+581
+00:59:04,620 --> 00:59:11,310
+«bigelation» عملية الـ «big interferon»هي عبارة عن
+
+582
+00:59:11,310 --> 00:59:18,330
+إضافة مُركّب آخر على الـ Interferon بحيث أنه بيطول
+
+583
+00:59:18,330 --> 00:59:22,550
+عمره وبيخلّي الـ Half-Life أطول وبيخلّي تأثير
+
+584
+00:59:22,550 --> 00:59:27,010
+الدواء يستمر لمدة أطول فعملية الـ Pegylation هي
+
+585
+00:59:27,010 --> 00:59:31,190
+عبارة عن Modification للبروتين التبع الدواء
+
+586
+00:59:31,190 --> 00:59:38,430
+وأحيانًا بنستفيد منها في خاصية هذه إنه بتخلّي الـ
+
+587
+00:59:39,150 --> 00:59:43,130
+الـ Enzyme أو الـ «هورمون» أو الـ «دراج» اللي
+
+588
+00:59:43,130 --> 00:59:49,590
+مطلوب بتخلّي مدته في الجسم طويلة ففي حالات الـ ADA
+
+589
+00:59:49,590 --> 00:59:53,470
+Deficiency اللي هو الـ «دينوسين دي أميناس»
+
+590
+00:59:53,470 --> 00:59:57,950
+الـEnzyme اللي في حالات الـSevere Combined Immune
+
+591
+00:59:57,950 --> 01:00:04,610
+Deficiency الحالات اللي هي نخس المناعة الـ
+
+592
+01:00:06,240 --> 01:00:09,880
+للـ T و الـ B-cells يعني الـ Combined الـ Both
+
+593
+01:00:09,880 --> 01:00:17,160
+خلال المناعة المكتسبة أو المناعة المتخصصة اللي هم
+
+594
+01:00:17,160 --> 01:00:20,440
+الـ T و الـ B-Lymphocytes أثنين هم بيكونوا قليلين
+
+595
+01:00:20,440 --> 01:00:27,580
+و مش شغالين و بيصير عندنا أمراض كثيرة فهذه لما أنا
+
+596
+01:00:27,580 --> 01:00:36,240
+أعطي الـ Big ADAممكن أنه يحسن الوضع ماعندي خبرة في
+
+597
+01:00:36,240 --> 01:00:43,680
+الحالات هذه يعني الـSCID أنا بعرف أنه أهم شيء لهم
+
+598
+01:00:43,680 --> 01:00:49,620
+لما يكون فيه تشخيص مبكر أنه يتم عملية نقل نخبع
+
+599
+01:00:49,620 --> 01:00:56,670
+العضم من شخص قريببشكل مفيد وراح نحكي عن آليات أخرى
+
+600
+01:00:56,670 --> 01:01:03,770
+إذا ما توفر donor كويس ممكن الواحد يعني يأخذ الـ
+
+601
+01:01:03,770 --> 01:01:08,010
+Pomero تبع الأو خلايا نفس المريض عدّلها جينياً في
+
+602
+01:01:08,010 --> 01:01:12,370
+المختبر ويرجع لها هي مرة ثانية يعني قضية الـ
+
+603
+01:01:12,370 --> 01:01:15,710
+Pomero للآن الـ Hemoglobinopathies
+
+604
+01:01:17,880 --> 01:01:21,220
+الـ Immune Deficiencies الـ Primary Immune
+
+605
+01:01:21,220 --> 01:01:25,980
+Deficiencies هي الأشياء اللي يعني مقبولة ومعروف
+
+606
+01:01:25,980 --> 01:01:33,500
+أنها بتوفر وبتفيد وكويسة الـ Other types of
+
+607
+01:01:33,500 --> 01:01:38,700
+disease treatment اللي هو زي الـ Cofactor أو زي
+
+608
+01:01:38,700 --> 01:01:43,320
+الـ Vitamin B6 اللي هو سيستينيوريا بتكون برضه ممكن
+
+609
+01:01:43,320 --> 01:01:49,710
+استفيد منها فهذه أمثلةلـ Molecular Treatments لـ
+
+610
+01:01:49,710 --> 01:01:55,750
+Genetic Diseases وهي بعض الأليات والأفكار بالنسبة
+
+611
+01:01:55,750 --> 01:02:01,110
+للعلاجات هو أنا بدي أثبت إنه دراسة معينة على حالة
+
+612
+01:02:01,110 --> 01:02:10,050
+معينة لما أعطوا الدواء هذا هنا دراسة تعتبر نسبياً
+
+613
+01:02:10,050 --> 01:02:18,280
+كبيرة على 83 حالة، ضالهم لحد 77 حالةكيف أنه يعني
+
+614
+01:02:18,280 --> 01:02:23,620
+في مقابل سبعين حالة مااخدوش الدواء أو أخدوا المادة
+
+615
+01:02:23,620 --> 01:02:30,480
+الخاملة شوية سكر اللي هو Ivacaftor
+
+616
+01:02:30,480 --> 01:02:37,500
+اللي هو كليدوليكون في الـ Cystic Fibrosis ده حكينا
+
+617
+01:02:37,500 --> 01:02:42,160
+عن إنه كيف هذا بيشتغل وكده بس يعني ماعندي خبرة
+
+618
+01:02:42,160 --> 01:02:44,560
+وماشوفتش إشي زي هيك
+
+619
+01:02:47,550 --> 01:02:54,450
+يعني هذا يجعل الواحد يتذكر الأمثل الأكبر اللي
+
+620
+01:02:54,450 --> 01:02:59,830
+أعطيناهم إياها بس يعني الواحد يلاحظ كثير من
+
+621
+01:02:59,830 --> 01:03:05,510
+الأشياء Investigational يعني هذه كلها إبارة عن
+
+622
+01:03:05,510 --> 01:03:11,120
+أمثلة على أدوية في لسة مراحل الدراسةأحيانًا، يعني
+
+623
+01:03:11,120 --> 01:03:15,400
+ممكن يثبت أن الدواء حتى هو أسوأ من المرض ويقتل
+
+624
+01:03:15,400 --> 01:03:19,140
+المريض بشكل أسرع بالـ Side Effect تبع الدواء
+
+625
+01:03:19,140 --> 01:03:25,080
+أحيانًا والشغل الثاني، مشكلة توفر هذه الأدوية وذات
+
+626
+01:03:25,080 --> 01:03:30,840
+أنها Very Expensive فحتى هذا الدواء يعني مثلًا
+
+627
+01:03:30,840 --> 01:03:34,300
+حاطين عنه Expensive إذا هم حاطين Expensive يبقى
+
+628
+01:03:34,300 --> 01:03:43,280
+Very Very Expensive ففيه يعنيمجال أو فيه احتمالية
+
+629
+01:03:43,280 --> 01:03:55,300
+إن الواحد يعني من خلال فهمه للقليات التحكم بالـ
+
+630
+01:03:55,300 --> 01:04:03,080
+Expression للجيل في تكوين البروتين يعني هذول
+
+631
+01:04:03,080 --> 01:04:09,940
+الأدوية بهذا الشكل المتخصصعبارة عن إذا ثبت وإذا تم
+
+632
+01:04:09,940 --> 01:04:13,720
+إكتشافه
+
+633
+01:04:13,720 --> 01:04:22,280
+وتجريبه إنه ما لهوش أثار جانبية وكويس بتلاقي بيكون
+
+634
+01:04:22,280 --> 01:04:28,160
+إشي يعني مفيد جداً ورائع جداً يعني هذه مبادئ
+
+635
+01:04:28,160 --> 01:04:35,390
+التغيير في الـفي الـ Gene Expression على مستوى حيث
+
+636
+01:04:35,390 --> 01:04:45,270
+أنه بشكل متخصص والأمر بربط بشكل كبير أحيانًا في
+
+637
+01:04:45,270 --> 01:04:50,250
+هذه المواضيع بفكرة الـ Signal Transduction في الـ
+
+638
+01:04:50,250 --> 01:04:56,350
+Controlيعني الدواء مهم كثير مثلًا لنقل الأعضاء الـ
+
+639
+01:04:56,350 --> 01:05:02,370
+«cyclosporin» بيشتغل على ميكانزم لتنشيط الـ
+
+640
+01:05:02,370 --> 01:05:06,770
+«interlocking tube» اللي مطلوب لوظيفة الـ «T-cell»
+
+641
+01:05:06,770 --> 01:05:12,830
+بحيث أنه بخلي الجسم يتقبل نقل العظم، نقل الأعضاء
+
+642
+01:05:12,830 --> 01:05:17,830
+حتى لو مافيش تطابق بإنه نمنع المناعة إنها تشتغل
+
+643
+01:05:18,320 --> 01:05:23,080
+فحكينا على الـ Vitamin B6 في الـ «بيردوكسين
+
+644
+01:05:23,080 --> 01:05:27,320
+رسبونسيف هموسستينيوريا» الـ Homocystinuria مرض
+
+645
+01:05:27,320 --> 01:05:33,100
+برضه بيصير إفراز الـ «Homocystin» وزيادة فيه في
+
+646
+01:05:33,100 --> 01:05:37,060
+الدم وفي الـBall أحيانًا ففيه نوعية منه «Bioduccin
+
+647
+01:05:37,060 --> 01:05:43,050
+Responsive» وشكلهلأنه بيشتغل كـ «فايتامين» كـ Co
+
+648
+01:05:43,050 --> 01:05:51,430
+-Factor لـ Enzyme فبحسم لما نزيد المستوى ففي
+
+649
+01:05:51,430 --> 01:05:55,050
+خمسين بالمائية من الحالات الـ Responsive تانية،
+
+650
+01:05:55,050 --> 01:06:00,290
+هذي بيكون ميوتاشنز مختلفة وبتكون أشياء بتفيد الـ
+
+651
+01:06:00,290 --> 01:06:06,630
+Protein Augmentation حكينا عن الـ «فاكتور 8» أو
+
+652
+01:06:06,630 --> 01:06:10,410
+أحيانا «فاكتور 9»والـ «established» و «effective»
+
+653
+01:06:10,410 --> 01:06:13,670
+و «safe» وما عدا أحياناً كانوا زمان
+
+654
+01:06:13,670 --> 01:06:19,070
+«cryoprecipitate» يعني يجيبون من البني أدمين فكان
+
+655
+01:06:19,070 --> 01:06:27,410
+يصير مرات قضية يعني إنه ما يقدروش يفصلوا كل
+
+656
+01:06:27,410 --> 01:06:31,670
+الأمراض المعضية فكان الـ «Hepatitis B» وحتى الـ
+
+657
+01:06:31,670 --> 01:06:37,790
+«HIV» وكذا يكون موجودالـ Recombinant DNA
+
+658
+01:06:37,790 --> 01:06:42,350
+Technology الـ Recombinant يعني إنه الجين اللي
+
+659
+01:06:42,350 --> 01:06:46,910
+بديه أو البروتين اللي بديه أخلي زي الإنسليل مثلاً
+
+660
+01:06:46,910 --> 01:06:51,570
+أخلي البكتيريا هي اللي تصنعه عن طريق أن أعزل الجين
+
+661
+01:06:51,570 --> 01:06:56,930
+تبعه أحطه على بلازمد أو فكتر من الفيروس نحقنه
+
+662
+01:06:56,930 --> 01:07:00,330
+بالبكتيريا، نعطي البكتيريا الأكل بتصير هي تنتج
+
+663
+01:07:00,330 --> 01:07:04,230
+منها مزرعة البروتين اللي أنا بديه أعزله وبعدين
+
+664
+01:07:04,230 --> 01:07:10,930
+برجع أعطيه للناسهذه الفكرة كاتبين إنه ممكن نستفيد
+
+665
+01:07:10,930 --> 01:07:17,230
+منها في الـ ADA SCID اللي هو Severe Combined
+
+666
+01:07:17,230 --> 01:07:21,290
+Immune
+
+667
+01:07:21,290 --> 01:07:26,050
+Deficiency وهي هو يمكن إن أنا معلومة ماكنتش عارفها
+
+668
+01:07:26,050 --> 01:07:34,340
+كثير إنه الدواء هذا بالطريقة هذهمؤقتًا تستخدم
+
+669
+01:07:34,340 --> 01:07:38,080
+لتحسين
+
+670
+01:07:38,080 --> 01:07:42,000
+وضع المريض حتى يتحمل الـ HLA-Bomber
+
+671
+01:07:42,000 --> 01:07:49,860
+Transplantation يعني مفيد مؤقتًا عبارة عن النسق
+
+672
+01:07:49,860 --> 01:07:56,240
+لعملية نقل النخاع عظم بعدها لهذه الحالة الـ
+
+673
+01:07:56,240 --> 01:07:58,600
+Goutier Disease
+
+674
+01:08:01,020 --> 01:08:06,440
+يعني هو من الأمراض برضه الـ Nervous System برضه
+
+675
+01:08:06,440 --> 01:08:13,480
+Beta-Glucose Reprosidase Deficiency فأنا بعوض الـ
+
+676
+01:08:13,480 --> 01:08:18,860
+Protein هذا يعني أظن أنه مطلوب مش ذاكر في الـ
+
+677
+01:08:18,860 --> 01:08:26,360
+Bomber ولا في الـيعني مطلوب يكون في الـ «nervous
+
+678
+01:08:26,360 --> 01:08:30,860
+system» أو بيكفّي الكبد لأن الكبد هو أهم واحد للـ
+
+679
+01:08:30,860 --> 01:08:38,340
+«metabolism» بشكل عام يعني فأحيانًا يعني بيكون إذا
+
+680
+01:08:38,340 --> 01:08:47,180
+حد بعرف مثل الإكحالات أنه ممكن يكون بتكون
+
+681
+01:08:47,180 --> 01:08:52,190
+هي نوع من الأدوية المفيدةأحيانًا أنا بعدل في وظيفة
+
+682
+01:08:52,190 --> 01:09:18,970
+الـ’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’�
+
+683
+01:09:19,250 --> 01:09:24,390
+يتكوّن الإنزايم الكامل فأحيانًا إذا في عندى
+
+684
+01:09:24,390 --> 01:09:29,510
+mutation بحيث إنه على الـ «level» العادى من الـ
+
+685
+01:09:29,510 --> 01:09:36,890
+«vitamin cofactor» بيكون إنه نسبة الإنزايم الكامل
+
+686
+01:09:36,890 --> 01:09:41,910
+قليلة السبب إن هذا الـ «cofactor» لما بيشتغل هنا
+
+687
+01:09:41,910 --> 01:09:47,110
+ما بيعطينا functional very good result
+
+688
+01:09:47,930 --> 01:09:52,750
+بينما لما أنا أزيد الـ «vitamin cofactor level»
+
+689
+01:09:52,750 --> 01:09:57,170
+بشكل كبير كثير عندما أعطي جرع عالي جدًا في الحالة
+
+690
+01:09:57,170 --> 01:10:04,830
+هذه يعني بنجبر الـ «cofactor» على إنه يلتصق بالـ
+
+691
+01:10:04,830 --> 01:10:11,810
+حتى الـ «muted» الـ «apoenzyme» بحيث إنه يعني يحسن
+
+692
+01:10:11,810 --> 01:10:18,270
+نسبة وظيفة الـ «enzyme» المطلوببحيث إنه بيخفف من
+
+693
+01:10:18,270 --> 01:10:27,210
+المرض فهذه أمثلة يعني على الأمراض
+
+694
+01:10:27,210 --> 01:10:32,050
+والحالات وأمثلة
+
+695
+01:10:32,050 --> 01:10:39,310
+عليها يعني الملاحظ في أفكار جميلة كثير في أفكار
+
+696
+01:10:39,310 --> 01:10:45,260
+يعني كيف الواحد يعالج يخلص من المشاكلأحيانًا تعويض
+
+697
+01:10:45,260 --> 01:10:51,000
+البروتين نفسه أحيانًا تعديل إذا شيء بيساعد على إن
+
+698
+01:10:51,000 --> 01:11:01,700
+المرض ما يظهر كدا وهنا يعني بيكرروا نفس الأفكار
+
+699
+01:11:01,700 --> 01:11:08,950
+لأن كثير منها من الأشياءحاطين Investigational
+
+700
+01:11:08,950 --> 01:11:13,670
+وInvestigational مبسوطين هنا على أنه «سهل» «تجارب
+
+701
+01:11:13,670 --> 01:11:14,850
+التجارب التجاربية التجاربية التجاربية التجاربية
+
+702
+01:11:14,850 --> 01:11:14,970
+التجاربية التجاربية التجاربية التجاربية التجاربية
+
+703
+01:11:14,970 --> 01:11:16,290
+التجاربية التجاربية التجاربية التجاربية التجاربية
+
+704
+01:11:16,290 --> 01:11:18,210
+التجاربية التجاربية التجاربية التجاربية التجاربية
+
+705
+01:11:18,210 --> 01:11:20,310
+التجاربية التجاربية التجاربية التجاربية التجاربية
+
+706
+01:11:20,310 --> 01:11:26,110
+التجاربية التجاربية التجاربية التجاربية التجاربية
+
+707
+01:11:26,110 --> 01:11:36,970
+التجاربية التجاربية التجاربية التجاربيةيعني إنه مش
+
+708
+01:11:36,970 --> 01:11:43,110
+تعطي إيش لمرضى له نسبة قليلة إنه بيموتوا لأ، هذا
+
+709
+01:11:43,110 --> 01:11:49,810
+بدك تثبت إنه الدواء أو التداخل أو طريقة العلاج أول
+
+710
+01:11:49,810 --> 01:11:55,990
+شيء مش قاتلة في هذه الناحية أو مش مضرة في هذه
+
+711
+01:11:55,990 --> 01:12:00,020
+المرحلة الأولى، ويكون عدد قليلإذا ثبت والله إله
+
+712
+01:12:00,020 --> 01:12:04,980
+شغل مافيش منه خطر مافيش منه ضرر بحط المرحلة ثاني
+
+713
+01:12:04,980 --> 01:12:13,000
+بزيد عدد الحالات وبصير أدور على يعني أقيم في أثر
+
+714
+01:12:13,000 --> 01:12:17,640
+في تحسين في الأثر اللي أنا بديها يعني كلكم الآن
+
+715
+01:12:17,640 --> 01:12:25,660
+بتابعوا السباق في العالم لـ مثلا الـ «Covid-19
+
+716
+01:12:25,660 --> 01:12:30,060
+Vaccine»فدائماً بيقولوا Stage 1 و Stage 2 و Stage
+
+717
+01:12:30,060 --> 01:12:39,300
+3 أو Phase 1 و Phase 2 و Phase 3 يعني قبل ما، لحد
+
+718
+01:12:39,300 --> 01:12:44,980
+ما نثبت أن الدواء فعال ومش مضر، يعني هذولا
+
+719
+01:12:44,980 --> 01:12:50,870
+الناحيتينوبكون بالأول، يعني حتى نثبت هذا الكلام من
+
+720
+01:12:50,870 --> 01:12:54,690
+خلال دراسات زي ما شُفته قبل شوية بتكون قضية أنه
+
+721
+01:12:54,690 --> 01:13:01,090
+أنا ممكن أعطي ناس placebo يعني بأعطيهم إشي ميّه
+
+722
+01:13:01,090 --> 01:13:06,550
+ملح يعني أو ما بأعطيهم إشي حقيقي يعني فهذه لأنها
+
+723
+01:13:06,550 --> 01:13:12,670
+تكون يعني دراسة بشكل سليم وبتكون زي ما بقولوا
+
+724
+01:13:12,670 --> 01:13:17,890
+blind، blind يعنيفيه الطبيب المعالج والمريض نفسه
+
+725
+01:13:17,890 --> 01:13:21,950
+ما بعرف هو انعطى الدواء الحقيقي اللي بدنا ندرسه
+
+726
+01:13:21,950 --> 01:13:28,150
+ولا نعطى placebo يعني مي وملح ومافيش فيه إشي لأن
+
+727
+01:13:28,150 --> 01:13:32,050
+العامل النفسي له تأثير كبير يعني أحيانًا في تحسن
+
+728
+01:13:32,050 --> 01:13:36,630
+المرضى 30% من متأثير الأدوية عادة بتكون placebo
+
+729
+01:13:36,630 --> 01:13:41,990
+يعني فالممكن
+
+730
+01:13:43,260 --> 01:13:49,920
+RNA interference يعني أني أعطيه RNA segment «أنا
+
+731
+01:13:49,920 --> 01:13:54,040
+ماعرفش هذه، ماعنديش خبرة فيها» induction of axons
+
+732
+01:13:54,040 --> 01:13:59,180
+skipping الـ «جين إدتينج» الـ «جين إدتينج» يعني
+
+733
+01:13:59,180 --> 01:14:06,240
+هذه الموضوع يعني إذا بدنا نتخيلها كطريقة علاج very
+
+734
+01:14:06,240 --> 01:14:14,290
+promising بس للآن حسب علمي مافيشما فيش يعني
+
+735
+01:14:14,290 --> 01:14:17,550
+تعديلها،
+
+736
+01:14:17,550 --> 01:14:25,990
+يعني استخدامها في نوع من العلاج
+
+737
+01:14:25,990 --> 01:14:32,090
+مرض معين كعلاج مقبول وكويس وكذا اللي هو موضوع
+
+738
+01:14:32,090 --> 01:14:41,710
+CRISPR9 هذا نوع من الأسليب المتطورة جداًفي المعالج
+
+739
+01:14:41,710 --> 01:14:46,230
+الوراثية «Gene Editing» يعني إن أنا بصير عندي
+
+740
+01:14:46,230 --> 01:14:53,770
+إنكالية أن أمسك أي قطعة الـ «DNA» بديّها وهي تم
+
+741
+01:14:53,770 --> 01:14:59,310
+اكتشافها من خلال البكتيريا وقلياتها في الدفاع عن
+
+742
+01:14:59,310 --> 01:15:05,730
+نفسها يعني نقل الخواص ودفاعها ضد الأمراض أو الغزو
+
+743
+01:15:05,730 --> 01:15:12,340
+من الفيروسات أو من إشي تانيفتستخدم البروتين أو
+
+744
+01:15:12,340 --> 01:15:18,820
+قلية الـ CRISPR9 الـ CRISPR9 يعني الـ Gene Editing
+
+745
+01:15:18,820 --> 01:15:23,420
+يعني أنا بجيب قطعة الـ DNA اللي بديها إذا كان
+
+746
+01:15:23,420 --> 01:15:29,720
+مثلاً في مكان مثلاً T ثايمين بحط أدينين، بحط
+
+747
+01:15:29,720 --> 01:15:34,680
+بجوانين، بحط اللي بديها ففي محل محدد أنا بشيل الـ
+
+748
+01:15:34,680 --> 01:15:39,780
+Nucleotide وبحط إشي تاني زي ما أنا بديفالآن
+
+749
+01:15:39,780 --> 01:15:42,840
+استخدام
+
+750
+01:15:42,840 --> 01:15:47,120
+هذه التقنية إذا بيقدروا بعدين يثبتوا إنها كويسة
+
+751
+01:15:47,120 --> 01:15:54,900
+لموضوع زي الـ «فلسيميا» زي الـ «التخلص الأساسي»
+
+752
+01:15:54,900 --> 01:16:00,480
+لما سهلة وده بتعرفها وعرفت شو المطلوب وشو الخلل
+
+753
+01:16:00,480 --> 01:16:05,460
+اللي موجود وعرفت الطفرة بالذات شو هي بيكون مقبول
+
+754
+01:16:05,460 --> 01:16:06,940
+وكويس أخلاقياً
+
+755
+01:16:10,740 --> 01:16:16,020
+بالنسبة لـ CRISPR الواحدين اللي استخدموه حقيقة
+
+756
+01:16:16,020 --> 01:16:24,760
+بشكل لا أخلاقي هما في الصين واحد بن قوسين يعتبرونه
+
+757
+01:16:24,760 --> 01:16:33,040
+مختل وحجروا عليه وحبسوه بعدين وكذا طبيب حاول يعمل
+
+758
+01:16:33,040 --> 01:16:42,340
+CCR5 جينالـ activation في الأجنة
+
+759
+01:16:42,340 --> 01:16:51,040
+تبعت عائلة HIV positive يعني الفكرة هنا أن أبوه
+
+760
+01:16:51,040 --> 01:17:02,280
+ثري جداً صيني أظن ويلدله الـ CRISPR في الجنين يعني
+
+761
+01:17:02,280 --> 01:17:10,220
+في الـfertilized egg للآنفيه يعني .. يعني هنا
+
+762
+01:17:10,220 --> 01:17:14,580
+بتعطينا مجال إنه نلعب بالماد الوراثية تبع الإنسان
+
+763
+01:17:14,580 --> 01:17:23,040
+أو تبع الكائن الحي فلما نكون .. يعني وفاق من
+
+764
+01:17:23,040 --> 01:17:29,500
+المشاكل الأخلاقية الوراثة بتدخلنا فيها إنه .. إنه
+
+765
+01:17:29,500 --> 01:17:35,030
+..إذا عندي مرض معروف وبدأ أستخدم هذه التقنية عشان
+
+766
+01:17:35,030 --> 01:17:40,610
+أعالج المرض، هذا مقبول وإذا بتقدر تثبت إنه كويس،
+
+767
+01:17:40,610 --> 01:17:46,190
+تمام بس هذا الإنسان والتجربة الصينية هذه كانت في
+
+768
+01:17:46,190 --> 01:17:54,010
+إنهم يحاولوا حسب الـMutationفي الـ CCR5 اللي
+
+769
+01:17:54,010 --> 01:17:58,150
+اتكلمنا عنها مرة في نسبة للـ Variation للـ
+
+770
+01:17:58,150 --> 01:18:03,210
+Susceptibility للـ HIV يعني في ناس لاحقوا إنه حتى
+
+771
+01:18:03,210 --> 01:18:06,930
+لو اتعرض للـ HIV ما بنصاب ما بيقدر الـ Virus يدخل
+
+772
+01:18:06,930 --> 01:18:13,260
+جوا الخلايا السبب إنه عنده شكل الـ CCR5 مختلففهذا
+
+773
+01:18:13,260 --> 01:18:18,200
+الصيني بدّه بناته ما يتعرضوا لأن هو ومرته كانوا
+
+774
+01:18:18,200 --> 01:18:21,840
+عندهم انشابي نفسهم بيأخذ أدوية وبيعالج حاله بس
+
+775
+01:18:21,840 --> 01:18:27,180
+بدّه زيادة في التأكد بدّه الأجنة تبعته الأولاد
+
+776
+01:18:27,180 --> 01:18:34,400
+وبناته يطلعوا ما عندهم أو عندهم الجين المقاوم بهذه
+
+777
+01:18:34,400 --> 01:18:45,740
+الطريقة فاشتغلوا CRISPR علىعلى الأجنة وهذا أخلاقيا
+
+778
+01:18:45,740 --> 01:18:54,840
+غير مقبول السبب أن هذا شيء دينيا وعلميا وأخلاقيا
+
+779
+01:18:54,840 --> 01:19:00,930
+للآن محرم ومجرم وعشان ذلك يعنيفي حتى محاولة تمنع
+
+780
+01:19:00,930 --> 01:19:06,670
+عملية إجراء الدراسات على الأجنة والأجنة جزء منها
+
+781
+01:19:06,670 --> 01:19:12,690
+بيطلع زيادة على بعد عمليات التلقيح خارج الجسم In
+
+782
+01:19:12,690 --> 01:19:17,090
+-vitro fertilization فأحيانًا بيظل الأجنة زايدة
+
+783
+01:19:17,090 --> 01:19:21,010
+فاللي بيحاول أنه يشتغل على هذه الأشياء بتكون مش
+
+784
+01:19:21,010 --> 01:19:26,550
+مظبوطة فللآن الـGene Editing promising يعني واعد
+
+785
+01:19:26,550 --> 01:19:35,630
+ممكن يستخدمولكن يعني فيه مشاكل أخلاقية ممكن الواحد
+
+786
+01:19:35,630 --> 01:19:41,570
+يعني يعمل «بوميرو ترانسفلانتيشن» «Core Blood Stem
+
+787
+01:19:41,570 --> 01:19:47,750
+Cell Transplantation» «Liver Transplantation» برضه
+
+788
+01:19:47,750 --> 01:19:55,290
+ممكن يعني بالذات فقيت الـ «Liver» في قضيةإن
+
+789
+01:19:55,290 --> 01:20:00,210
+أحيانًا كثيرة الـenzymes للـ«ميتابوليزم» بتكون في
+
+790
+01:20:00,210 --> 01:20:05,070
+الـLiver فلما واحد ينقل liver كويس لإنسان ثاني
+
+791
+01:20:05,070 --> 01:20:13,490
+ممكن يعوض المشاكل يعني آي
+
+792
+01:20:13,490 --> 01:20:19,770
+برضه دراسات أشياء ثانية الفكرة
+
+793
+01:20:19,770 --> 01:20:25,290
+في الـPomeroإنه يعني
+
+794
+01:20:25,290 --> 01:20:29,810
+الحسانف أو الميزة في الـ Bomber أو الـ Stem Cell
+
+795
+01:20:29,810 --> 01:20:37,490
+بقول إنه ميكانيكيا وأدائها يعني نقل الكبد يعني
+
+796
+01:20:37,490 --> 01:20:44,970
+عملية خطرة وطويلة ومعقدة ويعني إلها مشاكلها
+
+797
+01:20:44,970 --> 01:20:51,490
+الكبيرة وكذا إن الواحد ينقل الكبد منسواء المتبرع
+
+798
+01:20:51,490 --> 01:20:58,210
+حي زي قريب للمريض أو من cadaver يعني إنسان ميت
+
+799
+01:20:58,210 --> 01:21:05,850
+دماغياً وكدا دايماً فيها أشكالات كبيرة فأظن هيك
+
+800
+01:21:05,850 --> 01:21:09,830
+Somatic
+
+801
+01:21:09,830 --> 01:21:13,690
+tissue الـ
+
+802
+01:21:13,690 --> 01:21:18,880
+Gene Therapyيعني هنا الـ Somatic Tissue بنحاول أنه
+
+803
+01:21:18,880 --> 01:21:23,360
+نحط يعني
+
+804
+01:21:23,360 --> 01:21:29,620
+الفكرة هنا زي المثال اللي حكيته أنا عن الـ CRISPR
+
+805
+01:21:29,620 --> 01:21:36,960
+هو عبارة عن أخده الأجنة الخلية الملقحة الأولى وعدل
+
+806
+01:21:36,960 --> 01:21:42,270
+فيها فالنتيجة بتصير أنهالتغيير والتعديل اللي أنا
+
+807
+01:21:42,270 --> 01:21:46,450
+سويته موجود في كل الخلايا أما لو أخدت جزء من
+
+808
+01:21:46,450 --> 01:21:51,790
+الخلايا في جسم الإنسان كامل وعدلت فيها إشي ورجعتله
+
+809
+01:21:51,790 --> 01:21:56,670
+إياها هذه بتكون يعني بدنا نسميها Somatic Tissue
+
+810
+01:21:56,670 --> 01:22:03,970
+Modification يعني مثلا أخدت من إنسان قطعة كبد
+
+811
+01:22:03,970 --> 01:22:09,130
+وبعدين بالطريقة اللي ماوأنا حاطي إن الـ Retroviral
+
+812
+01:22:09,130 --> 01:22:14,410
+Vector أو بسلوب معين دخلت إشي تاني أهم جانب في
+
+813
+01:22:14,410 --> 01:22:18,510
+إدخال جينات جديدة عن طريق الـ Bomber هو أسهل واحد
+
+814
+01:22:18,510 --> 01:22:23,630
+وأكثر واحد يعني يستخدم في أشياء كثيرة يعني أظن هيك
+
+815
+01:22:23,630 --> 01:22:35,750
+خلصنا أمثلة يعني إن شاء الله تكون يعني هي فصل فيه
+
+816
+01:22:35,750 --> 01:22:49,170
+أشياء كثيرةمتقدم كثير، يعني أحيانًا لسه مش مثبت
+
+817
+01:22:49,170 --> 01:22:58,470
+كثير هات الواحد يكون متأكد منها وبدها طب قوي جدًا،
+
+818
+01:22:58,470 --> 01:23:05,370
+يعني متقدم، فيه عنده خبرة وفهم طبعًا الأمراض
+
+819
+01:23:05,370 --> 01:23:10,020
+الوراثية اللي بهذا الشكلفي الغالب، يعني غير
+
+820
+01:23:10,020 --> 01:23:13,600
+الثلاثيمي أو الـ Sickle Cell لأنها قريبة كثيرًا في
+
+821
+01:23:13,600 --> 01:23:20,160
+كثير أشياء يعني بحيث أنها تكون نادرة وجزء من نجاعة
+
+822
+01:23:20,160 --> 01:23:31,160
+وتحسن الدواء المعين هو في أنه يتم
+
+823
+01:23:31,160 --> 01:23:39,700
+تجربته من خلال تجارب علميا سليمة وكويسةفإذا في حد
+
+824
+01:23:39,700 --> 01:23:50,680
+عنده أسئلة أهلا وسهلا فيكم أو بنختم هكذا في سؤال
+
+825
+01:23:50,680 --> 01:23:57,660
+يا دكتور من كريم بخصوص الأمراض والتدخلات التي تم
+
+826
+01:23:57,660 --> 01:24:05,380
+ذكرها كلها تقول أن عددها كبير وتشعوباتها كثيرةأيش
+
+827
+01:24:05,380 --> 01:24:11,040
+اللي مطلوب نركز عليه منها أو أيش المفترض نحفظه
+
+828
+01:24:11,040 --> 01:24:19,040
+منها بمعنى هذا؟ لأ، انت شوف، أنا بقترح نركز على
+
+829
+01:24:19,040 --> 01:24:24,360
+اللي أنا اتكلمت عنه في المحاضرات يعني الـDenisol
+
+830
+01:24:24,360 --> 01:24:30,650
+Hereditary Angioneurotic Edemaوالله موجود وبستخدمه
+
+831
+01:24:30,650 --> 01:24:37,270
+وعندي مثلا اللي عندهم Hemophilia وبعطيه Protein
+
+832
+01:24:37,270 --> 01:24:43,310
+هذا واضح ومستخدم جداً ومرضى الـ Hemophilia أيهم
+
+833
+01:24:43,310 --> 01:24:48,090
+بيجوا على الطوارئ ويكون عندهم نزف في العضلات، في
+
+834
+01:24:48,090 --> 01:24:52,150
+المفاصل، في الـ «كدا» اللي هو مرض الناعور اللي هو
+
+835
+01:24:52,150 --> 01:24:57,570
+Hemophilia اللي هو شدة النزف، شايف عليا؟فهي
+
+836
+01:24:57,570 --> 01:25:04,170
+الأشياء اللي أنا بظن … يعني أركز الواحد اللي فيها
+
+837
+01:25:04,170 --> 01:25:09,710
+جداول في قضية المبادئ وانا حرست إنه في المحاضرة
+
+838
+01:25:09,710 --> 01:25:16,430
+أشرح المبدأ وأعطيكم بعض المعلومات السريرية فهي
+
+839
+01:25:16,430 --> 01:25:22,020
+اللي أنا بتوقع اللي أتحكيت عنهاهي اللي ركزوا عليها
+
+840
+01:25:22,020 --> 01:25:27,880
+وده بس المحاضرة يعني بالنسبة
+
+841
+01:25:27,880 --> 01:25:35,560
+للمن يحكوا معلومة ويحطوها إنه لسه ضمن تجارب معينة
+
+842
+01:25:35,560 --> 01:25:42,380
+هذا دليل على إنها لسه مش إشي ثابت ومعتمد بس بيظل
+
+843
+01:25:42,380 --> 01:25:48,560
+إنه ممكن يعني إنه ممكن في المستقبل يعني الدنيا
+
+844
+01:25:48,560 --> 01:25:55,590
+تتطور قبلقبل 40 سنة أو 30 سنة لما أنا كنت طالب كنا
+
+845
+01:25:55,590 --> 01:25:58,970
+كلنا طبنا على المراجع والكتب و«ديفيدسون»
+
+846
+01:25:58,970 --> 01:26:03,430
+و«هاريسون» وتروح المكتب وتروح الدو وتمسك الكتاب
+
+847
+01:26:03,430 --> 01:26:08,510
+وتقعد كذا لأن الدنيا اتغيرت كلنا على الـ «جوجل»
+
+848
+01:26:08,510 --> 01:26:14,650
+وعلى الكمبيوتر و«أب تو ديت» و«باب ميد» والأشياء
+
+849
+01:26:14,650 --> 01:26:22,080
+هذه آليات الدنيا أحيانًا بتختلففأنا بظن يعني
+
+850
+01:26:22,080 --> 01:26:28,100
+الواحد يأخذها هدف الواحد منها أنه يطلع دكتور كويس
+
+851
+01:26:28,100 --> 01:26:31,840
+الدكتور الكويس بدي يكون مجهز حاله للمستقبل
+
+852
+01:26:31,840 --> 01:26:38,000
+المستقبل نحكي فيه أنه يعني يمكن اليوم والآن وفي
+
+853
+01:26:38,000 --> 01:26:44,060
+هذه اللحظة يعني أنا ما بدعي أنه حتى الأردن ولا حتى
+
+854
+01:26:44,060 --> 01:26:49,810
+جيرانكم ولا في فلسطين وغزةحتى عند اليهود يعني
+
+855
+01:26:49,810 --> 01:26:53,410
+مثلًا يهود بشكل عام متقدمين يعني بالذات في الأمراض
+
+856
+01:26:53,410 --> 01:26:59,170
+الوراثية يعني بتلاقيهم حارسين عليها الآن المبدأ
+
+857
+01:26:59,170 --> 01:27:06,590
+أنه أنا أفهم المبدأ يعني أن هذا ممكن أنا إذا بشك
+
+858
+01:27:06,590 --> 01:27:13,710
+أنه الحالة وراثية وفي تاريخ عائلي وكذا حتى لو
+
+859
+01:27:17,190 --> 01:27:22,330
+حتى لو ما فيش في الدنيا زي الحال من قبل المفروض إن
+
+860
+01:27:22,330 --> 01:27:28,230
+الواحد يسعى إنه يفهم الـ Pathogenesis عشان يفكر في
+
+861
+01:27:28,230 --> 01:27:34,550
+دوة بأسلوب معين فالتفكير هذا يعني أنا والله اللي
+
+862
+01:27:34,550 --> 01:27:38,390
+هو سرطان هذا في الـ Marfan أول مرة بدري عنه يعني
+
+863
+01:27:38,390 --> 01:27:41,650
+أنا ماكنتش منتبه إلو يعني أو على الأقل ماعنديش
+
+864
+01:27:41,650 --> 01:27:46,670
+الاختصاص الكبير هذا فيهفإن الواحد يكون منتبه إنه
+
+865
+01:27:46,670 --> 01:27:51,850
+له سرطان وقراءة Carbo شائع جداً ودواء يعني نسبياً
+
+866
+01:27:51,850 --> 01:28:00,730
+بسيط يعني .. يعني available ومش غالي ويعني من
+
+867
+01:28:00,730 --> 01:28:06,950
+أنواع الأدوية الضغط الأغلى شوية بس يعني مش very
+
+868
+01:28:06,950 --> 01:28:10,530
+very expensive وvery available فوالله الواحد هذا
+
+869
+01:28:10,530 --> 01:28:15,710
+بيفيد مرض زي هيكأنا باعتبر أن هذه معلومة مهمة يعني
+
+870
+01:28:15,710 --> 01:28:22,210
+أنا بالنسبة إليه يعني ماشي فالآن يا كريم أنتوا في
+
+871
+01:28:22,210 --> 01:28:28,690
+صباق أنتوا كمجموعة طلاب طب في الجامعة في صباق بدك
+
+872
+01:28:28,690 --> 01:28:35,970
+تكون الأول بدك تكون أحسن بتعرف أكتر وانت وحر ماشي
+
+873
+01:28:35,970 --> 01:28:42,910
+غيره؟ في أسئلة في نفس المواضيع يعني؟في نفس
+
+874
+01:28:42,910 --> 01:28:48,930
+الأدوية؟ غالباً لأ يا دكتور طيب يالله يعطيكم
+
+875
+01:28:48,930 --> 01:28:53,290
+العافية ونشوفكم الأسبوع القادم إن شاء الله سؤال
+
+876
+01:28:53,290 --> 01:28:57,750
+آخر دكتور أحمد بالنسبة للامتحان
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/td1N2Fp6EAU_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/td1N2Fp6EAU_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..9bf8055279a2bcc379930cbadf0a6806b6d405a3
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/td1N2Fp6EAU_raw.json
@@ -0,0 +1 @@
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"text": "يعني إذا بتذكروا الـ Sickle Cell اللي هو بالذات يعني لما يكون فيه مشاكل جزء مهم من تحديد درجة الإصابة في الـ Sickle Cell بتكون مستوى الـ Hemoglobin F الـ Hemoglobin F، سبحان الله، إذا ظهر موجود يعني أنت الـ", "tokens": [40228, 22653, 11933, 15730, 39894, 8848, 37983, 14407, 2423, 39184, 43471, 306, 28859, 13672, 1829, 31439, 20666, 8848, 9307, 37495, 22653, 5296, 15042, 7251, 30544, 8978, 3224, 37893, 995, 28820, 10874, 11622, 38207, 3714, 16095, 9154, 6055, 5016, 16254, 3215, 11778, 47341, 3660, 33688, 9381, 16758, 3660, 8978, 2423, 39184, 43471, 306, 28859, 39894, 30544, 3714, 14851, 2407, 7578, 2423, 39184, 18568, 45841, 13496, 479, 2423, 39184, 18568, 45841, 13496, 479, 12399, 8608, 49628, 7649, 21984, 12399, 11933, 15730, 1357, 116, 3224, 2288, 3714, 29245, 23328, 37495, 22653, 14739, 2655, 2423, 39184], "avg_logprob": -0.14331317012028028, "compression_ratio": 1.6802030456852792, "no_speech_prob": 1.2516975402832031e-06, "words": [{"start": 2724.13, "end": 2724.51, 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"end": 2748.69, "word": " موجود", "probability": 0.9527994791666666}, {"start": 2748.69, "end": 2749.73, "word": " يعني", "probability": 0.91455078125}, {"start": 2749.73, "end": 2750.87, "word": " أنت", "probability": 0.8095703125}, {"start": 2750.87, "end": 2751.97, "word": " الـ", "probability": 0.801025390625}], "temperature": 1.0}, {"id": 108, "seek": 278091, "start": 2752.19, "end": 2780.91, "text": "في الغالب الإنسان بيقولوله SA يعني الـ Hemoglobin تبعه اللي عنده … اللي إذا كان مصاب SS، Sickle Cell Disease، ماشي؟ فيه Sickle Cell Carrier SA، حتى المصابين لما نيجي نعمل حتى Protein Electrophoresis أو Hemoglobin Electrophoresis", "tokens": [41185, 6024, 118, 6027, 3555, 33688, 1863, 3794, 7649, 4724, 1829, 39648, 12610, 3224, 16482, 37495, 22653, 2423, 39184, 18568, 45841, 13496, 6055, 3555, 3615, 3224, 13672, 1829, 43242, 3224, 5799, 13672, 1829, 11933, 15730, 25961, 3714, 9381, 16758, 12238, 12399, 43471, 306, 28859, 35360, 12399, 3714, 33599, 1829, 22807, 8978, 3224, 43471, 306, 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Disease،", "probability": 0.6895751953125}, {"start": 2767.27, "end": 2768.37, "word": " ماشي؟", "probability": 0.81201171875}, {"start": 2768.37, "end": 2768.81, "word": " فيه", "probability": 0.681640625}, {"start": 2768.81, "end": 2769.19, "word": " Sickle", "probability": 0.96923828125}, {"start": 2769.19, "end": 2769.45, "word": " Cell", "probability": 0.96630859375}, {"start": 2769.45, "end": 2770.07, "word": " Carrier", "probability": 0.957275390625}, {"start": 2770.07, "end": 2771.89, "word": " SA،", "probability": 0.5711669921875}, {"start": 2771.89, "end": 2772.65, "word": " حتى", "probability": 0.79833984375}, {"start": 2772.65, "end": 2773.65, "word": " المصابين", "probability": 0.97607421875}, {"start": 2773.65, "end": 2774.03, "word": " لما", "probability": 0.682861328125}, {"start": 2774.03, "end": 2774.33, "word": " نيجي", "probability": 0.9305419921875}, {"start": 2774.33, "end": 2774.75, "word": " نعمل", "probability": 0.9957682291666666}, {"start": 2774.75, "end": 2775.23, "word": " حتى", "probability": 0.908203125}, {"start": 2775.23, "end": 2776.59, "word": " Protein", "probability": 0.693603515625}, {"start": 2776.59, "end": 2778.49, "word": " Electrophoresis", "probability": 0.9658203125}, {"start": 2778.49, "end": 2778.87, "word": " أو", "probability": 0.97607421875}, {"start": 2778.87, "end": 2779.81, "word": " Hemoglobin", "probability": 0.96240234375}, {"start": 2779.81, "end": 2780.91, "word": " Electrophoresis", "probability": 0.984375}], "temperature": 1.0}, {"id": 109, "seek": 280783, "start": 2781.37, "end": 2807.83, "text": "بنلاقي ممكن يعني لأنه في فترة في حياة الإنسان كان عنده Hemoglobin-F مش الـHemoglobin من هذا النوع فالملاحظ أنه لو إنسان ضال عنده إنتاج للـHemoglobin-F نسبة أكبر بيصير المرض أخف والسبب أنه كل ما ارتفع كمية الـHemoglobin-F", "tokens": [3555, 1863, 15040, 38436, 3714, 43020, 37495, 22653, 5296, 33456, 3224, 8978, 6156, 2655, 25720, 8978, 11331, 25528, 3660, 33688, 1863, 3794, 7649, 25961, 43242, 3224, 18568, 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"word": " هذا", "probability": 0.9677734375}, {"start": 2788.99, "end": 2789.35, "word": " النوع", "probability": 0.98974609375}, {"start": 2789.35, "end": 2791.83, "word": " فالملاحظ", "probability": 0.96611328125}, {"start": 2791.83, "end": 2792.69, "word": " أنه", "probability": 0.798095703125}, {"start": 2792.69, "end": 2793.37, "word": " لو", "probability": 0.95947265625}, {"start": 2793.37, "end": 2794.47, "word": " إنسان", "probability": 0.9427083333333334}, {"start": 2794.47, "end": 2795.59, "word": " ضال", "probability": 0.5889892578125}, {"start": 2795.59, "end": 2796.17, "word": " عنده", "probability": 0.990478515625}, {"start": 2796.17, "end": 2796.91, "word": " إنتاج", "probability": 0.9309895833333334}, {"start": 2796.91, "end": 2798.11, "word": " للـHemoglobin", "probability": 0.9073893229166666}, {"start": 2798.11, "end": 2798.47, "word": "-F", "probability": 0.991943359375}, {"start": 2798.47, "end": 2799.31, "word": " نسبة", "probability": 0.9344075520833334}, 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يعني تعديلها، يعني استخدامها في نوع من العلاج مرض معين كعلاج مقبول وكويس وكذا اللي هو موضوع CRISPR9 هذا نوع من الأسليب المتطورة جداً", "tokens": [15042, 8978, 8592, 37495, 22653, 37279, 16254, 1211, 11296, 12399, 37495, 22653, 44713, 9778, 3215, 10943, 11296, 8978, 8717, 45367, 9154, 18863, 1211, 26108, 3714, 43042, 20449, 9957, 9122, 30241, 26108, 3714, 4587, 3555, 12610, 4032, 4117, 45865, 3794, 4032, 4117, 15730, 13672, 1829, 31439, 3714, 2407, 11242, 45367, 49256, 15958, 24, 23758, 8717, 45367, 9154, 16247, 3794, 1211, 1829, 3555, 9673, 2655, 9566, 13063, 3660, 10874, 28259, 14111], "avg_logprob": -0.14765625702483312, "compression_ratio": 1.5769230769230769, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 4451.59, "end": 4451.81, "word": "ما", "probability": 0.51416015625}, {"start": 4451.81, "end": 4452.31, "word": " فيش", "probability": 0.910400390625}, {"start": 4452.31, "end": 4454.29, "word": " يعني", "probability": 0.693359375}, {"start": 4454.29, "end": 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"text": "في المعالج الوراثية «Gene Editing» يعني إن أنا بصير عندي إنكالية أن أمسك أي قطعة الـ «DNA» بديّها وهي تم اكتشافها من خلال البكتيريا وقلياتها في الدفاع عن نفسها يعني نقل الخواص ودفاعها ضد الأمراض أو الغزو من الفيروسات أو من إشي تاني", "tokens": [41185, 9673, 3615, 6027, 7435, 2423, 13063, 5718, 104, 10632, 4657, 38, 1450, 3977, 1748, 5933, 37495, 22653, 36145, 41850, 4724, 9381, 13546, 18871, 16254, 36145, 4117, 6027, 10632, 14739, 5551, 2304, 3794, 4117, 36632, 12174, 9566, 27884, 2423, 39184, 4657, 35, 5321, 5933, 4724, 16254, 11703, 11296, 37037, 1829, 46811, 1975, 4117, 2655, 8592, 31845, 11296, 9154, 16490, 1211, 6027, 29739, 4117, 2655, 13546, 25528, 4032, 4587, 20292, 9307, 11296, 8978, 32748, 5172, 45761, 18871, 8717, 36178, 11296, 37495, 22653, 8717, 4587, 1211, 33962, 2407, 33546, 4032, 3215, 5172, 45761, 11296, 48812, 3215, 16247, 29973, 46958, 34051, 6024, 118, 11622, 2407, 9154, 27188, 13546, 41779, 9307, 34051, 9154, 11933, 8592, 1829, 6055, 7649, 1829], 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ثايمين بحط أدينين، بحط بجوانين، بحط اللي بديها ففي محل محدد أنا بشيل الـ Nucleotide وبحط إشي تاني زي ما أنا بدي", "tokens": [5172, 2655, 14851, 9778, 40448, 2423, 26890, 35473, 9957, 34051, 12174, 1211, 10632, 2423, 39184, 49256, 15958, 24, 2423, 39184, 49256, 15958, 24, 37495, 22653, 2423, 39184, 18083, 3977, 1748, 37495, 22653, 41850, 4724, 7435, 1829, 3555, 12174, 9566, 27884, 2423, 39184, 8272, 13672, 1829, 4724, 16254, 11296, 11933, 15730, 25961, 50113, 15040, 14111, 8978, 3714, 41361, 50113, 15040, 14111, 314, 38637, 995, 32640, 9957, 4724, 5016, 9566, 5551, 3215, 9957, 9957, 12399, 4724, 5016, 9566, 4724, 7435, 2407, 7649, 9957, 12399, 4724, 5016, 9566, 13672, 1829, 4724, 16254, 11296, 6156, 41185, 3714, 5016, 1211, 3714, 24401, 3215, 41850, 4724, 8592, 26895, 2423, 39184, 426, 1311, 306, 310, 482, 46599, 5016, 9566, 11933, 8592, 1829, 6055, 7649, 1829, 30767, 1829, 19446, 41850, 4724, 16254], "avg_logprob": -0.2204999966621399, "compression_ratio": 1.7725321888412018, 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{"start": 5304.07, "end": 5305.25, "word": " كمجموعة", "probability": 0.8900960286458334}, {"start": 5305.25, "end": 5305.91, "word": " طلاب", "probability": 0.9833984375}, {"start": 5305.91, "end": 5306.33, "word": " طب", "probability": 0.95654296875}, {"start": 5306.33, "end": 5306.63, "word": " في", "probability": 0.95947265625}, {"start": 5306.63, "end": 5307.33, "word": " الجامعة", "probability": 0.9918619791666666}, {"start": 5307.33, "end": 5307.63, "word": " في", "probability": 0.9775390625}, {"start": 5307.63, "end": 5308.07, "word": " صباق", "probability": 0.9892578125}, {"start": 5308.07, "end": 5308.69, "word": " بدك", "probability": 0.71826171875}, {"start": 5308.69, "end": 5309.55, "word": " تكون", "probability": 0.989990234375}, {"start": 5309.55, "end": 5310.13, "word": " الأول", "probability": 0.995849609375}, {"start": 5310.13, "end": 5310.67, "word": " بدك", "probability": 0.79443359375}, {"start": 5310.67, "end": 5311.13, "word": " تكون", "probability": 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"duration_after_vad": 5263.78596875002}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/td1N2Fp6EAU_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/td1N2Fp6EAU_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..d6432a13c18a310794cc22aa60770fafdb5766f2
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/td1N2Fp6EAU_raw.srt
@@ -0,0 +1,3520 @@
+1
+00:00:00,000 --> 00:00:02,400
+مرحبًا ورحمة الله وبركاته بسم الله الرحمن الرحيم
+
+2
+00:00:02,400 --> 00:00:10,300
+دائمًا نحكي إنه في بداية أي محاضرة إذا حد عنده
+
+3
+00:00:10,300 --> 00:00:15,520
+استفسار عن ما تم ذكره أو شرحه من قبل أو ما تم
+
+4
+00:00:15,520 --> 00:00:19,780
+مناقشته
+
+5
+00:00:19,780 --> 00:00:23,300
+في المحاضرات السابقة ممكن واحد يبدأ نسأل يعني قبل
+
+6
+00:00:23,300 --> 00:00:28,060
+ما نبدأ المحاضرة المحاضرة
+
+7
+00:00:28,060 --> 00:00:39,140
+اليومهو الفصل الثالث عشر من الكتاب حقيقةً يعني فيه
+
+8
+00:00:39,140 --> 00:00:50,740
+معلومات صعوبة فيها أن بعضها عبارة عن علاجات وطرق
+
+9
+00:00:50,740 --> 00:00:58,020
+علاج يعني نسميها تجربية فبالتالي الـ
+
+10
+00:00:58,930 --> 00:01:06,030
+اللي قد لا تكون كلها من الأشياء المثبتة المعتمدة
+
+11
+00:01:06,030 --> 00:01:16,030
+اللي approved ويمكن استخدامها بس مش غلط إنه الواحد
+
+12
+00:01:16,030 --> 00:01:23,470
+ينتبه لمستويات علاجات ومعالجة الأمراض الوراثية
+
+13
+00:01:23,470 --> 00:01:27,050
+بالنسبة
+
+14
+00:01:27,050 --> 00:01:34,470
+لـمحاضرة اليوم أنا بظن يعني من أهم الأشياء اللي
+
+15
+00:01:34,470 --> 00:01:43,630
+يعني بتعطينا هيكة للعلاجات الممكنة بيظل العلاج
+
+16
+00:01:43,630 --> 00:01:52,350
+الأخير في الأسفل وهو العلاج على مستوى العائلة الـ
+
+17
+00:01:52,350 --> 00:01:55,750
+Genetic Counseling الـ Career Screening الـ Pre
+
+18
+00:01:55,750 --> 00:02:01,970
+-Symptomatic Diagnosisمبادئ من الطرق
+
+19
+00:02:01,970 --> 00:02:07,870
+العلاج اللي أحيانًا تتفاوت وحسب الحالة وحسب المرض
+
+20
+00:02:07,870 --> 00:02:16,190
+وسيكون هناك إن شاء الله فصل لاحق في المثاق
+
+21
+00:02:16,190 --> 00:02:22,450
+عن آليات وكيفية عمل الـGenetic Counseling ما هي
+
+22
+00:02:22,450 --> 00:02:28,740
+مبادئه وكيف ده نسويه وشو بنعمل فيه والأشياء هذهإذا
+
+23
+00:02:28,740 --> 00:02:36,280
+افترضنا إن الأمراض اللي ناتجة عن خلل في الجينات
+
+24
+00:02:36,280 --> 00:02:43,620
+بالأخير راح تظهر بروتيم معين لأن الجين هو الشفرة
+
+25
+00:02:43,620 --> 00:02:50,200
+الوراثية لبروتينات معينة وبالتالي سيكون المحصلة هو
+
+26
+00:02:50,200 --> 00:02:56,890
+إنتاج بروتيم معينمستويات العلاجات أو مستويات أنواع
+
+27
+00:02:56,890 --> 00:03:05,850
+التدخلات الممكنة ممكن أن نقوم بتعديل نفس الجين
+
+28
+00:03:05,850 --> 00:03:16,520
+المصاب يعني طبعاً هذه قضية كبيرة جداً وهناكفي
+
+29
+00:03:16,520 --> 00:03:21,760
+صعوبة بالغة بتعديل الجين أي إنسان إذا ذكرنا إن هذه
+
+30
+00:03:21,760 --> 00:03:26,880
+الجينات والمادة الوراثية في كل الخلايا متشابهة
+
+31
+00:03:26,880 --> 00:03:32,580
+والأصل إنها محددة من لحظة التكون والتخلق عند تلقيح
+
+32
+00:03:32,580 --> 00:03:39,550
+البائظة فمن تلك اللحظة الأصل أنهكل المادة الوراثية
+
+33
+00:03:39,550 --> 00:03:44,470
+في كل الخلايا ناتجة متشابهة إلا إذا حصلت عملية
+
+34
+00:03:44,470 --> 00:03:56,010
+طفرات غير مخططة لها، فبتكون تحدث فأحياناً نستطيع
+
+35
+00:03:56,010 --> 00:04:06,010
+أن نغير في الـSomatic Genotype يعني في خلايا الجسم
+
+36
+00:04:06,010 --> 00:04:15,060
+بعد ذلكويعني هذه قضية بتكون في حالات محددة بقضية
+
+37
+00:04:15,060 --> 00:04:20,120
+نقل الأعضاء اللي هو مثلًا أو أسهلها من هذه الناحية
+
+38
+00:04:20,120 --> 00:04:25,080
+هي قضية للأشياء الوراثية عملية نقل النخاع العظيم
+
+39
+00:04:25,080 --> 00:04:29,080
+أو يمكن الـ Stem Cells اللي هي الخلايا الجدعية
+
+40
+00:04:29,080 --> 00:04:34,540
+بطريقة علاج ففيه هناك بعض الأمراض ما يمكن استخدام
+
+41
+00:04:34,540 --> 00:04:36,820
+هذا الأسلوب
+
+42
+00:04:38,610 --> 00:04:45,550
+لأن هناك محاولات أخرى يعني الإشكالية إنك كيف تدخل
+
+43
+00:04:45,550 --> 00:04:52,270
+الـ «جين» في داخل النواة، في داخل الخلية، في كل
+
+44
+00:04:52,270 --> 00:04:58,790
+خلية يعني، فهي الأمر مش سهل، فهناك محاولات أخرى
+
+45
+00:04:58,790 --> 00:05:08,470
+لإعطاء أدوية لتغيير الـ «جين» expressionوهو نابع
+
+46
+00:05:08,470 --> 00:05:14,730
+يعني كمثال أيضًا من الـ Sickle Cell باستخدام دوة
+
+47
+00:05:14,730 --> 00:05:21,490
+اللي هو Dicetabine ولحد
+
+48
+00:05:21,490 --> 00:05:27,010
+الآن يعني هو تجريبي، الكلام قديم شوية في الكتاب
+
+49
+00:05:27,010 --> 00:05:33,890
+تبعكم ويمكن أن أصبح مقبول أكثر، بحاول بطريقة فهم
+
+50
+00:05:35,370 --> 00:05:40,390
+العوامل اللي تتحكم في الـ Gene والـ Gene
+
+51
+00:05:40,390 --> 00:05:49,910
+Expression ممكن الواحد يعني يصلح ويزيد من إفراز أو
+
+52
+00:05:49,910 --> 00:05:57,950
+تكوين Gene معين هناك محاولات
+
+53
+00:05:58,580 --> 00:06:04,320
+عن طريق أقباء اللي هو الـ Mutant Messenger RNA
+
+54
+00:06:04,320 --> 00:06:08,000
+عشان
+
+55
+00:06:08,000 --> 00:06:11,760
+نكون بتدخل
+
+56
+00:06:11,760 --> 00:06:18,080
+وبتحطيم بروتين أحنا لا نرغب فيه زي الـ Amylodosis
+
+57
+00:06:18,080 --> 00:06:21,640
+كمرض
+
+58
+00:06:21,640 --> 00:06:28,500
+يعنيسواء مرات أنواع منه الـ Amyloid deposits مثلًا
+
+59
+00:06:28,500 --> 00:06:33,440
+بالـ Alzheimer أو في مثلًا نفس الـ Classical
+
+60
+00:06:33,440 --> 00:06:38,220
+Amyloidosis الـ Amyloidosis، هذا مرات راح نحكي عنه
+
+61
+00:06:38,220 --> 00:06:47,710
+أحيانًا نقوم بالـ Protein Replacement يعنيإنه ماشي
+
+62
+00:06:47,710 --> 00:06:53,950
+هذا الإنسان عنده بروتين مصعب أنا بعطي زي مثلا واحد
+
+63
+00:06:53,950 --> 00:06:58,470
+عنده homophilia أو نقص factor A بسير بشكل عند
+
+64
+00:06:58,470 --> 00:07:03,850
+الاحتياج أو بشكل متكرر بعطي cryoprecipitate أو
+
+65
+00:07:03,850 --> 00:07:09,690
+بعطي recomponent factor A أو كده أو مثلا زي حالات
+
+66
+00:07:09,690 --> 00:07:13,670
+مرض الـ Goucher اللي هو من الـ Metabolic Diseases
+
+67
+00:07:14,210 --> 00:07:21,550
+بيكون فيه نقص إنزايم معين «جلوكو سيريبرو سيديز»
+
+68
+00:07:21,550 --> 00:07:27,090
+بيصير نعطيها بلاحظ أنه بيفيد وبحسن وكذا أحياناً
+
+69
+00:07:27,090 --> 00:07:32,090
+التأثير على الـ Mutant Protein بتغيير أو بتعويض أو
+
+70
+00:07:32,090 --> 00:07:41,830
+بتداخل مع إعطاء الـإذا كان من المشاكل إن وظيفة
+
+71
+00:07:41,830 --> 00:07:46,970
+البروتين صارت أضعف نعطيه إشي بيخلي وظيفة البروتين
+
+72
+00:07:46,970 --> 00:07:51,630
+هذا أقوى وأحسن وبنحسنها فالـ Pyridoxin in classic
+
+73
+00:07:51,630 --> 00:08:01,250
+hemocystinuria بيكون تحسين يعني الآن عن طريق فهمنا
+
+74
+00:08:01,250 --> 00:08:02,810
+لـ
+
+75
+00:08:06,170 --> 00:08:12,510
+اليّة المرض مثلًا مثلًا الـ Phenylketonuria ومعرفة
+
+76
+00:08:12,510 --> 00:08:16,110
+العامل المسبب للأعراض مثلًا مثلًا مثلًا الـ
+
+77
+00:08:16,110 --> 00:08:22,090
+Phenylalanine في هذه الحالة ممكن أنا أدخل أنه أطلب
+
+78
+00:08:22,090 --> 00:08:27,330
+أنه نغيّر الحمية تبع الإنسان هذا الـ Dietary
+
+79
+00:08:27,330 --> 00:08:31,370
+Intervention بحيث أنه نعطيه لو Phenylalanine، ديات
+
+80
+00:08:31,370 --> 00:08:34,910
+أو لو بروتين، ديات بشكل عام، بالذات إذا فيه بروتين
+
+81
+00:08:35,920 --> 00:08:41,420
+high with phenylalanine حيث أنه نمنع أعراض تبعات
+
+82
+00:08:41,420 --> 00:08:45,380
+المرض ما نتدخل في البروتين، ما نتدخل في الجيل على
+
+83
+00:08:45,380 --> 00:08:50,760
+مستوى الـ Metabolic Metabolism أو على مستوى نفس
+
+84
+00:08:50,760 --> 00:08:56,600
+الألية
+
+85
+00:08:56,600 --> 00:09:02,100
+تبع التسبب بالمرض، استخدمها في علاجه في
+
+86
+00:09:02,100 --> 00:09:07,690
+الـUricicle defects مثلاًالـ Sodium Benzoate برضه
+
+87
+00:09:07,690 --> 00:09:15,490
+بيغير وبعدل في آليات تسبب
+
+88
+00:09:15,490 --> 00:09:24,290
+المرض والـ pathogenesis أحيانًا ندخل لتخفيف مظهر
+
+89
+00:09:24,290 --> 00:09:27,610
+المرض مثلًا اللي عنده ثلاثيميا أو Sickle Cell أصير
+
+90
+00:09:27,610 --> 00:09:33,910
+يعطيه Blood Transfusionمثلًا Surgical Intervention
+
+91
+00:09:33,910 --> 00:09:37,290
+مثلًا Correction of Congenital Heart Disease إذا
+
+92
+00:09:37,290 --> 00:09:45,330
+كان مرض نتيجته إنه فيه مثلًا خلل خلقي أو عيب خلقي
+
+93
+00:09:45,330 --> 00:09:51,770
+في القلب، برجي وأنا بتدخل فيعني اللي بد الواحد
+
+94
+00:09:51,770 --> 00:09:59,570
+يتذكره إنه أنا أحيانًا قد يكون عنديأليات، طبعًا كل
+
+95
+00:09:59,570 --> 00:10:05,190
+هذه التداخلات
+
+96
+00:10:05,190 --> 00:10:12,890
+الإلاجية بهذا الشكل بتقوم على أساس لازم يكون بعد
+
+97
+00:10:12,890 --> 00:10:18,610
+التفكير والتقدير والفهم
+
+98
+00:10:18,610 --> 00:10:26,070
+الـ Pathogenesis بيقوم الواحد بتطوير الدواء لتعطيل
+
+99
+00:10:26,070 --> 00:10:35,980
+أوتحسين جانب معين فنعمل بعدين دراسات حول هذه الطرق
+
+100
+00:10:35,980 --> 00:10:43,000
+من العلاجات وده طريقة العلاج نجحت
+
+101
+00:10:43,000 --> 00:10:50,440
+وسببت بشكل متكرر أثبتت
+
+102
+00:10:50,440 --> 00:10:57,630
+الدراسة منتحسين الوضع بيصير يعتمد وينشر وينقش في
+
+103
+00:10:57,630 --> 00:11:03,930
+المؤتمرات ويقيم الخبراء ويجرب الناس على مستوى أكبر
+
+104
+00:11:03,930 --> 00:11:11,470
+وأكبر وأكبر ومش غلط أن الواحد يكون منتبه لهذه
+
+105
+00:11:11,470 --> 00:11:16,770
+الخيارات من الإلاجات حتى يشترك
+
+106
+00:11:16,770 --> 00:11:21,850
+في علاج كثير من الأمراضكل واحد حسب خبرته حسب اللي
+
+107
+00:11:21,850 --> 00:11:28,490
+بيشوفه بحسب يعني بدها في شكل كبير مراكز متخصصة
+
+108
+00:11:28,490 --> 00:11:36,650
+بدها ناس اشتغلت على هذه العلاجات حتى يعني يقيمها
+
+109
+00:11:36,650 --> 00:11:42,430
+الإنسان ويشوف درجة نجاحها فـ
+
+110
+00:11:46,320 --> 00:11:55,740
+الدراسات تتفاوت أيش الأشياء الممكن استخدامها يعني
+
+111
+00:11:55,740 --> 00:12:04,360
+هذه هنا
+
+112
+00:12:04,360 --> 00:12:16,640
+ملخص مرة ثانيةلأنواع الإلاجات بشكل مجمل هنا لأمراض
+
+113
+00:12:16,640 --> 00:12:27,860
+الوراثية الـ Mandelian وبقوم نسبة نوعية استفادة
+
+114
+00:12:27,860 --> 00:12:34,160
+الناس منها ضمن دراسة معينة في وقت معين، ماعرفش كم
+
+115
+00:12:34,160 --> 00:12:40,690
+مرض هنايعني العدد الكلي للأمراض اللي تم تقييمها
+
+116
+00:12:40,690 --> 00:12:48,350
+ويعني نسبة الاستفادة منها ولدرجة قبولها كطريقة
+
+117
+00:12:48,350 --> 00:12:55,810
+إلاج نتكلم في الـProduct Replacement مثلاً زي الدم
+
+118
+00:12:55,810 --> 00:13:00,690
+في حالة الثلاثيمية Substrate Restriction مثلاً
+
+119
+00:13:00,690 --> 00:13:02,090
+الـDietary
+
+120
+00:13:04,440 --> 00:13:10,020
+مثلًا مثلًا الـ Phenylalanine والبروتينز الـ Bq
+
+121
+00:13:10,020 --> 00:13:13,540
+الـ Toxin Removal الـ Coenzyme Supplementation الـ
+
+122
+00:13:13,540 --> 00:13:16,680
+Inhibition of Toxic أو الـ Toxin Production أو الـ
+
+123
+00:13:16,680 --> 00:13:21,160
+Effect الـ Enzyme Replacement Therapy يعني مش شايف
+
+124
+00:13:21,160 --> 00:13:28,380
+إنه فرق كتير عن رقم واحد الخلايا اللي يعني ممكن
+
+125
+00:13:28,380 --> 00:13:35,120
+نفكر فيهالتعويض الـ gene في الإنسان المصاب تتفاوت
+
+126
+00:13:35,120 --> 00:13:39,000
+بين liver transplantation، bomber transplantation،
+
+127
+00:13:39,000 --> 00:13:42,460
+kidney transplantation البوميرو معاه الـ stem cell
+
+128
+00:13:42,460 --> 00:13:51,940
+في مرات كثيرة يعني فهدولة النسبأنا بظن يعني مش غلط
+
+129
+00:13:51,940 --> 00:13:58,000
+الواحد يتطلع عليها من مش مفيدة ويعني هي دراسة في
+
+130
+00:13:58,000 --> 00:14:04,800
+لحظة معينة على 57 مرض هنا في حالة Inborn Errors of
+
+131
+00:14:04,800 --> 00:14:09,520
+Metabolism يعني هدولة Specifically مجموعة أمراض
+
+132
+00:14:09,520 --> 00:14:14,960
+اللي فيها بالأخيرأو مشكلتهم مع ميتابوليزم
+
+133
+00:14:14,960 --> 00:14:17,640
+ومتابولكات المشروعات الموجودة في الشخص
+
+134
+00:14:23,040 --> 00:14:28,860
+الفكرة أنه كمان يعني هيك بشكل مجمل من دراسة محددة
+
+135
+00:14:28,860 --> 00:14:36,480
+نفسها اللي عرضناها قبل شوية أنه من سنة الـ 1983
+
+136
+00:14:36,480 --> 00:14:44,980
+هما 57 مرض و31 حالة
+
+137
+00:14:44,980 --> 00:14:51,550
+أو مرضيعني حتى العلاج اللي احنا بنحكي عنه بتلاقي
+
+138
+00:14:51,550 --> 00:14:58,190
+فيه No Response يعني الأفكار والطرق العلاجات كانت
+
+139
+00:14:58,190 --> 00:15:05,490
+مرتفعة من 57 يعني أكثر من النص بكثير كان فيه عدم
+
+140
+00:15:05,490 --> 00:15:14,850
+استجابة فيه 17% بتكون في استجابةبسيطة أو محدودة 9
+
+141
+00:15:14,850 --> 00:15:20,630
+على 9 أمراض الاستجابة أقل والنسبة عادة أقل بكثير
+
+142
+00:15:20,630 --> 00:15:27,370
+مافيش response هذا الكلام سنة الـ83 كل ما نتقدم
+
+143
+00:15:27,370 --> 00:15:33,670
+بالـ93 وأخرش دراسة بالـ2008 فراحة الكلمة الـ2008
+
+144
+00:15:34,230 --> 00:15:38,970
+بتقول إن هذه الدراسة قديمة جداً لأنه الآن يعني
+
+145
+00:15:38,970 --> 00:15:44,830
+عادةً خلال 12 سنة بتلاقي فيه تقدم أشد بكثير ويمكن
+
+146
+00:15:44,830 --> 00:15:50,710
+كان راح يعملوا دراسة يكملوا النتيجة الفكرة أنهمع
+
+147
+00:15:50,710 --> 00:15:57,210
+تقدم الوقت وحتى الكلام لسنة 2008 النسب صارت بالعكس
+
+148
+00:15:57,210 --> 00:16:01,110
+يعني صار عندنا أمراض أكثر من كثير عشرين مرات
+
+149
+00:16:01,110 --> 00:16:07,590
+تقريبًا نتوقع استجابة كاملة فيعني الفكرة أنه مع
+
+150
+00:16:07,590 --> 00:16:16,980
+فهم الأدب للمرض والـ Mechanism تبعهالجين تبعته،
+
+151
+00:16:16,980 --> 00:16:20,960
+الخلل كيف يكون في الجين وتأثير الخلل على البروتين
+
+152
+00:16:20,960 --> 00:16:28,060
+وتأثير البروتين الوظيفي كل الفهم هذا بيعطينا مع
+
+153
+00:16:28,060 --> 00:16:38,080
+تقدم الطب والعلم والفهم أدوات أقوى إننا نحسن المرض
+
+154
+00:16:38,080 --> 00:16:43,960
+ونخفف آثارهطبعاً بيظل أنه يعني النقطة اللي راح
+
+155
+00:16:43,960 --> 00:16:51,380
+ناخدها زي ما حكينا في محاضرة لاحقة قضية منع المرض
+
+156
+00:16:51,380 --> 00:16:54,160
+الـ Prevention يعني اللي هو الـGenetic Counseling
+
+157
+00:16:54,160 --> 00:17:00,320
+الـFamily Planning الـTesting الأشياء هذه اللي هي
+
+158
+00:17:00,320 --> 00:17:06,060
+برضه بتساعد أنه نمنع المرض حتى احتمالية حدوثه قبل
+
+159
+00:17:06,060 --> 00:17:09,440
+حدوثه يعني فهي مبادئ عامة
+
+160
+00:17:17,690 --> 00:17:26,330
+أحيانًا الأنواع من الأمراض إذا ثبتت بتكلموا عن إنه
+
+161
+00:17:26,330 --> 00:17:33,830
+ممكن أنا أحاول أعطي حتى الدواء في المرحلة الجنينية
+
+162
+00:17:33,830 --> 00:17:41,500
+يعني الـPrenatal الـPrenatal يعنيفي مرحلة جنينية
+
+163
+00:17:41,500 --> 00:17:54,660
+لسة قبل الولادة ماشي فإذا ثبت تشقيص أو نتيجة حالات
+
+164
+00:17:54,660 --> 00:18:01,640
+سابقة مع فحص الحامل
+
+165
+00:18:01,640 --> 00:18:09,140
+طبعاً هي وزوجها وأحياناً فحص جزء من الجنين عن طريق
+
+166
+00:18:11,280 --> 00:18:16,000
+فيتال، مثلًا الـ Sampling أحيانًا باخده من الـ
+
+167
+00:18:16,000 --> 00:18:21,680
+Machina أحيانًا باخده من الـ Ammoniotic Fluid بحطه
+
+168
+00:18:21,680 --> 00:18:27,620
+إبرة دقيقة جدًا في السائل حوالين الجنين وباخده منه
+
+169
+00:18:27,620 --> 00:18:33,280
+عينة وإذا عندك إمكانية تفحص على السبق النوعي يعني
+
+170
+00:18:33,280 --> 00:18:37,460
+الطفرة الوراثية المسببة للمرض ممكن يكون عندك خيار
+
+171
+00:18:37,460 --> 00:18:41,490
+إنك تعطي دوة أحيانًايعني هذه ظاهرة بتحدث إنك أنت
+
+172
+00:18:41,490 --> 00:18:49,150
+تعطي الأم يعني دوة أو شيء ممكن يخفف المرض يعني
+
+173
+00:18:49,150 --> 00:18:57,670
+أسرع أو أشع مرض أو حالة ممكن الواحد يخفف منها
+
+174
+00:18:57,670 --> 00:19:02,700
+بالعلاج اللي في خلال الحملمثلًا الـ Folic Acid هو
+
+175
+00:19:02,700 --> 00:19:08,200
+الـ «نيرونال دي فاكت» في الفتيات يعني الـ «نيرونال
+
+176
+00:19:08,200 --> 00:19:11,560
+دي فاكت» اللي هو الـ «نيرونال تيوب» أخدته في الـ
+
+177
+00:19:11,560 --> 00:19:17,600
+Empyrogenesis إن الجهاز العصبي في الإنسان يتكون عن
+
+178
+00:19:17,600 --> 00:19:26,050
+طريقالقناعة بالأول وبعدين بتلف بالكامل وبصير يعني
+
+179
+00:19:26,050 --> 00:19:31,850
+على شكل أنبوب عصبي هذا الأنبوب آخرته من فوق ومن
+
+180
+00:19:31,850 --> 00:19:37,450
+تحت المفروض يسكر ويضم ويلتم ففي حالة Spina Bifida
+
+181
+00:19:37,450 --> 00:19:43,610
+اللي هو الدرجات وأنواع وما قد تكون مفتوحة كثير
+
+182
+00:19:43,610 --> 00:19:54,660
+مفتوحة قليل فالـ Spina Bifidaيعني هذه حالة يعني
+
+183
+00:19:54,660 --> 00:20:00,360
+صراحة إذا الطفل يُصاب فيها إعاقة عصبية شديدة
+
+184
+00:20:00,360 --> 00:20:05,480
+وأحيانًا بتأثر على الماشي، على الجلوس على حركة شلل
+
+185
+00:20:05,480 --> 00:20:10,260
+الأطراف السفلية مثلًا، طبعًا دي أجت من جهة الدماغ
+
+186
+00:20:10,260 --> 00:20:15,060
+من فوق لسه أصعب بكثير ويمكن مايعيشش الجنين يعني،
+
+187
+00:20:15,060 --> 00:20:21,700
+فالـ Folic Acidإذا بتعطيه للمرأة الحامل بتعالج الـ
+
+188
+00:20:21,700 --> 00:20:28,700
+Defect هذا هو صحيح، يعني مش حالة ورافية بحيث إنهم
+
+189
+00:20:28,700 --> 00:20:36,620
+دخلوا ضمن هذه المجموعة بس حتى لو يعني لسبب أو لآخر
+
+190
+00:20:36,620 --> 00:20:43,170
+تم تشقيث أي من هذه الأمراضزي الـ «بيوتينيديز»
+
+191
+00:20:43,170 --> 00:20:47,390
+«بيوتينيديز»، «deficiency»، «بعرف شو بعمل»، «كوبة
+
+192
+00:20:47,390 --> 00:20:51,190
+مالي»، «كوبة الأمين»، «responsive»، «methyl
+
+193
+00:20:51,190 --> 00:20:55,870
+melanoc aciduria» برضه أو «congenital adrenal
+
+194
+00:20:55,870 --> 00:21:00,890
+hyperplasia»، «precoction»، «puberty» و«بتعمل
+
+195
+00:21:00,890 --> 00:21:06,570
+مشاكل»، «phosphoglycerate»،
+
+196
+00:21:06,570 --> 00:21:10,980
+«dehydrogenase deficiency»،اللي هو مطلوب للـ «إل
+
+197
+00:21:10,980 --> 00:21:15,200
+سايرين سينتاسيز» لتعوض الـ «إل سايرين» الـ
+
+198
+00:21:15,200 --> 00:21:22,820
+«Prenatal» فكل هذه أفكار لإذا تمكن الطبيب من تشخيص
+
+199
+00:21:22,820 --> 00:21:29,780
+هذه الأنواع من الأمراض الوراثية وبكون في الغالب
+
+200
+00:21:29,780 --> 00:21:35,240
+يعني صارت عندنا في عائلة تم اكتشاف في هذه الحالة
+
+201
+00:21:35,240 --> 00:21:43,050
+وبعدين تحمل الأممرة ثانية بجنين
+
+202
+00:21:43,050 --> 00:21:52,050
+آخر بيصير الواحد يفكر يعطل مثل اللي كان وياه يعني
+
+203
+00:21:52,050 --> 00:21:57,030
+دلوقتي نحن نتكلم أكثر مجموعة أكثر عن الـ Metabolic
+
+204
+00:21:57,030 --> 00:22:03,510
+Manipulation و Metabolic Diseases يعني هذه حكينا
+
+205
+00:22:03,510 --> 00:22:06,090
+يعني في أجزاء أنواع أشكال
+
+206
+00:22:08,680 --> 00:22:12,520
+متعددة مثل الـ Hemoglobinopathy مثل الـ Neuronal
+
+207
+00:22:12,520 --> 00:22:19,140
+مثل الـ Musculoskeletal مثل الـ Muscles وكذلك، لم
+
+208
+00:22:19,140 --> 00:22:23,100
+نتحدث عن هذه الأشياء نحن هنا على الأشياء اللي فيها
+
+209
+00:22:23,100 --> 00:22:27,680
+خلل بالـ Metabolism بالعمليات الأيض في الخلايا وفي
+
+210
+00:22:27,680 --> 00:22:35,040
+الجسم إذا إنسان عنده G6PD Deficiency في حد عنده
+
+211
+00:22:35,040 --> 00:22:39,780
+سؤال؟ أهإذا حد عندى سؤال، واقفني يا دكتور أحمد
+
+212
+00:22:39,780 --> 00:22:44,800
+وخلّيني أتشوف الـ G6PD Deficiency طبعاً هذا اللي
+
+213
+00:22:44,800 --> 00:22:51,700
+هو مرض التفؤل عبارة عن نقص من الإنزيمات المطلوبة
+
+214
+00:22:51,700 --> 00:23:04,790
+لتعديل وظيفة الإنزيم المسؤول عن بقاء شكلكورية الدم
+
+215
+00:23:04,790 --> 00:23:10,070
+الحمراء بالشكل الطبيعي فإذا بصير عندها G6PD
+
+216
+00:23:10,070 --> 00:23:16,190
+deficiency وهو الإنزين المطلوب للتعامل
+
+217
+00:23:16,190 --> 00:23:20,990
+مع الـ Glucose بالنسبة للـ Red Blood Cells بنتج
+
+218
+00:23:20,990 --> 00:23:26,390
+عنه Susceptibility to Hemolysis with either نفس
+
+219
+00:23:26,390 --> 00:23:32,010
+التعرض للفول، أكل الفول طبعاً الفول الطبيعي، مش
+
+220
+00:23:32,010 --> 00:23:37,520
+مدمسيعني عملية التدميس هذه وعشان نخليه مقبول للأكل
+
+221
+00:23:37,520 --> 00:23:45,020
+لأ بتقلل ويلها علاقة بالـ Antioxidants والأشياء
+
+222
+00:23:45,020 --> 00:23:49,680
+اللي بتكون يعني إلها قدرة على إنه تغير وتخرب
+
+223
+00:23:49,680 --> 00:23:55,060
+الخلايا فدول الناس بيسير بس يعني مثلا ممكن يمر جنب
+
+224
+00:23:55,060 --> 00:24:02,080
+حق الفول أو يمر يأكل فول أو بعض الأدويةمثلًا زي
+
+225
+00:24:02,080 --> 00:24:05,160
+الـ Antimalarial drugs الـ Chloroquine أو الـ
+
+226
+00:24:05,160 --> 00:24:08,240
+Hydroxychloroquine أحيانًا الـ Non-steroidal's
+
+227
+00:24:08,240 --> 00:24:13,080
+أنواع من الأدوية منتجة عنها المرض كله فاللي بيصير
+
+228
+00:24:13,080 --> 00:24:18,500
+أنه مثل هؤلاء الأشخاص ما يجب أنه نعطيه الـ
+
+229
+00:24:18,500 --> 00:24:23,600
+Antimalarial drugs حتى لو احتجناالـ Isoniazide
+
+230
+00:24:23,600 --> 00:24:29,380
+كمان فيه Slow Acetylators فيه مثلا Side Effect لـ
+
+231
+00:24:29,380 --> 00:24:32,880
+Warfarin ممكن أنا إذا بعرف واحد عنده Certain
+
+232
+00:24:32,880 --> 00:24:38,570
+Genetic Mutation مميع الـ Warfarin ممنوع أعطيهاالـ
+
+233
+00:24:38,570 --> 00:24:42,570
+Dietary Restriction أشهر واحد الـPKU اللي هو
+
+234
+00:24:42,570 --> 00:24:45,310
+الـProtein Diet اللي هو الـPhylalanalene Diet،
+
+235
+00:24:45,310 --> 00:24:50,970
+لازم تكون في ناس عندهم Galactosemia ليه
+
+236
+00:24:50,970 --> 00:24:58,790
+الـIncrease in Galactose، ماشي الـGalactosemia،
+
+237
+00:24:58,790 --> 00:25:05,040
+أهالـ .. يعني بدنا نمنع الـ Galactose بدوا الواحد،
+
+238
+00:25:05,040 --> 00:25:09,480
+ماعندي فكرة كثير، مش كيف بتكون بس بدوا الواحد يشوف
+
+239
+00:25:09,480 --> 00:25:15,920
+هذا السكر موجود في أنه مُركّبات، أنه أكلات الـBq
+
+240
+00:25:15,920 --> 00:25:21,780
+بالنسبة للفين على الأنالين يعني هو في غالب
+
+241
+00:25:21,780 --> 00:25:33,130
+البروتيناتمشتقات الأجبان، مشتقات الخبز، الذرة،
+
+242
+00:25:33,130 --> 00:25:39,610
+البطاطا يعني الخبز والذرة، القمح والذرة ممنوعات
+
+243
+00:25:39,610 --> 00:25:46,870
+أظن أن البطاطا مسموحة، الرز مسموح، الرز العادي لأ
+
+244
+00:25:46,870 --> 00:25:50,850
+مش مسموح يعني بتصير أكلات معينة مقبولة وأشياء مش
+
+245
+00:25:50,850 --> 00:25:56,640
+مقبولة، وبدوا الواحد ينتبهدُمن الأكل وين المادة
+
+246
+00:25:56,640 --> 00:26:01,840
+موجودة ولازم يبتعد عنها أحياناً بنسوي عملية
+
+247
+00:26:01,840 --> 00:26:10,860
+replacement زي congenital hypothyroidism هذه بنعطي
+
+248
+00:26:10,860 --> 00:26:15,640
+الـإذا كان جينيتال ومعروف عنها ممكن واحد يعطي الأم
+
+249
+00:26:15,640 --> 00:26:20,300
+إذا بقدر يدخل عليها ما بعرف هنا أما بعد الولادة،
+
+250
+00:26:20,300 --> 00:26:25,780
+إذا الطفل فيه ارثخاء، فيه تأخر في النمو، فيه جفاف،
+
+251
+00:26:25,780 --> 00:26:29,360
+لحتى يعني، و هذا بؤثر على، ليها مرض اسمه
+
+252
+00:26:29,360 --> 00:26:33,980
+«Cretinism» اللي هو يعني Hypothyroidism في
+
+253
+00:26:33,980 --> 00:26:40,350
+الـNeonates وفي الأطفال ويله شكل معين ويكونسهل
+
+254
+00:26:40,350 --> 00:26:45,190
+جدًا علاجه إذا تم تشخيصه مبكر قبل ما يعمل تلف دائم
+
+255
+00:26:45,190 --> 00:26:54,610
+مثل الـ Thyroxine الـ «بيوتينيدناز»
+
+256
+00:26:54,610 --> 00:26:57,770
+الـ «بيوتينيدناز» الـ «بيوتينيدناز» الـ
+
+257
+00:26:57,770 --> 00:26:57,770
+«بيوتينيدناز» الـ «بيوتينيدناز» الـ «بيوتينيدناز»
+
+258
+00:26:57,770 --> 00:26:57,770
+الـ «بيوتينيدناز» الـ «بيوتينيدناز» الـ
+
+259
+00:26:57,770 --> 00:26:57,870
+«بيوتينيدناز» الـ «بيوتينيدناز» الـ «بيوتينيدناز»
+
+260
+00:26:57,870 --> 00:26:57,870
+الـ «بيوتينيدناز» الـ «بيوتينيدناز» الـ
+
+261
+00:26:57,870 --> 00:26:58,010
+«بيوتينيدناز» الـ «بيوتينيدناز» الـ «بيوتينيدناز»
+
+262
+00:26:58,010 --> 00:27:01,460
+الـ «بيوتينيدناز» الـ «بيوتينيدناز» الـ «الـ Uric
+
+263
+00:27:01,460 --> 00:27:06,520
+Acid Disorders حكينا الـ Sodium Benzoate الفميلة
+
+264
+00:27:06,520 --> 00:27:12,820
+الـ Hypercholesterolemia، الـ heterozygote زي اللي
+
+265
+00:27:12,820 --> 00:27:15,600
+هو الـ drugs that sequester bile acids in the
+
+266
+00:27:15,600 --> 00:27:20,620
+intestine الليبدز
+
+267
+00:27:20,620 --> 00:27:25,100
+الـ Hypercholesterolemia بدأ الـ bile acids عشان
+
+268
+00:27:25,100 --> 00:27:31,560
+يتم انتصاصها فإذا يعني أضعفنا عملية الانتصاصالـ
+
+269
+00:27:31,560 --> 00:27:34,680
+Hypercholesterolemia اللي بتأثر كثير على الشرايين
+
+270
+00:27:34,680 --> 00:27:42,060
+وبتعمل ترسب للدهون وبتعمل تصلب الشرايين، بنوقفها،
+
+271
+00:27:42,060 --> 00:27:48,040
+بنساعد نفس الفكرة لنفس المرض، ممكن نعطي Statins،
+
+272
+00:27:48,040 --> 00:27:57,660
+برضه بتنمع المسبب في تكوين الكوليسترول وزيادة الـ
+
+273
+00:27:57,660 --> 00:28:03,920
+Level تفعفيه الـ Receptor Antagonism «مارفان
+
+274
+00:28:03,920 --> 00:28:07,980
+سندروم» الـ «لو سرطان» Investigational أول مرة
+
+275
+00:28:07,980 --> 00:28:12,260
+بنتبه عليه الـ «لو سرطان» هو الدوة من أدوية الضغط
+
+276
+00:28:12,260 --> 00:28:18,680
+«بال سرطان»، «لو سرطان»، «كاندي سرطان» هدولة
+
+277
+00:28:18,680 --> 00:28:25,460
+مجموعة من أدوية الضغط بتقوم على تثبيت
+
+278
+00:28:29,240 --> 00:28:35,840
+اللي هو الـ ARBs اللي هو Angiotensin Converting
+
+279
+00:28:35,840 --> 00:28:39,780
+Enzyme شبيهة في وظيفة الـ Angiotensin Converting
+
+280
+00:28:39,780 --> 00:28:46,120
+Enzyme Inhibitor فالـ
+
+281
+00:28:46,120 --> 00:28:47,460
+Losartan هذا
+
+282
+00:28:51,830 --> 00:28:58,230
+بقوم بتنزيل الضغط ويرفع الـ «بوتاسيوم» كـ side
+
+283
+00:28:58,230 --> 00:29:02,350
+effect له حقين أنه ممكن يستخدم في الـ Marfan
+
+284
+00:29:02,350 --> 00:29:13,910
+syndrome يعني هذه برضه محاولات لتحسين
+
+285
+00:29:13,910 --> 00:29:15,990
+الوضع هذا أحيانًا
+
+286
+00:29:18,040 --> 00:29:23,140
+يعني إنك انت بالذات اللي عنده «very high level of
+
+287
+00:29:23,140 --> 00:29:28,220
+lipids» بقول زي ما كنت حكيت مرة لما واحد يسحب الدم
+
+288
+00:29:28,220 --> 00:29:35,960
+تبعه بلاقي حليبي يعني مشبع بالدهون درجة عالية جداً
+
+289
+00:29:35,960 --> 00:29:41,860
+وهذا على المدى البعيد خطر جداًفحطين أنه في بعض الـ
+
+290
+00:29:41,860 --> 00:29:47,380
+أتوقع لأي واحد يقول إن هذا علاج تجريبي لـ LDL
+
+291
+00:29:47,380 --> 00:29:52,320
+Aphoresis اللي هي الـ Dialysis أو عملية غسيل الكلا
+
+292
+00:29:52,320 --> 00:29:57,940
+أو غسيل الدم أو كده إن أنا أاخد دم الإنسان هذا
+
+293
+00:29:57,940 --> 00:30:05,910
+وأسحب منه الأشي المضر مثلًاورجع له دمه مع ألبومين
+
+294
+00:30:05,910 --> 00:30:13,950
+سواء العادية أو بحيث أنه يقلل من مستوى الحالة أو
+
+295
+00:30:13,950 --> 00:30:21,090
+المرض يعني أنا أظن أشياء كثيرة هنا الواحد بتعلمها
+
+296
+00:30:21,090 --> 00:30:31,700
+وهذه أمثلة في تفاوت بين قدرات الأدوية هذهوالنقطة
+
+297
+00:30:31,700 --> 00:30:37,420
+اللي ذكرتناها أو يعني حطينا في
+
+298
+00:30:37,420 --> 00:30:43,000
+الـ «جرافات» اللي قبل إنه فيه تطور، فيه تحسن بس
+
+299
+00:30:43,000 --> 00:30:49,120
+أحياناً كثير من الأدوية حتى لما الواحد يجربها وحسب
+
+300
+00:30:49,120 --> 00:30:52,880
+ما بالدراسة بيقول أعطي الدواء لفلاني النسبة
+
+301
+00:30:52,880 --> 00:30:56,620
+الكبيرة منها ممكن للواحد مايلاقي أي استفادة ممكن
+
+302
+00:30:56,620 --> 00:31:03,060
+استفادة بسيطة جداًوالآن كل ما نتحسن أكثر في فهم
+
+303
+00:31:03,060 --> 00:31:06,340
+الأليات
+
+304
+00:31:06,340 --> 00:31:13,660
+للمرض وبالتالي طرق عمل الأدوية وبالتالي نزيد نسبة
+
+305
+00:31:13,660 --> 00:31:19,300
+الأشياء اللي بناقيلها أدوية بشكل عام، فهذه بعض
+
+306
+00:31:19,300 --> 00:31:20,160
+الأمثلة
+
+307
+00:31:25,110 --> 00:31:31,270
+بالنسبة للـ Ammonia بالنسبة للـ Urea Cycle Defect
+
+308
+00:31:31,270 --> 00:31:36,830
+الـ Sodium Benzoate اللي هي يعني إنه الـ Ammonia
+
+309
+00:31:36,830 --> 00:31:44,070
+بشكل يعني في
+
+310
+00:31:44,070 --> 00:31:49,460
+الإنسان الطبيعيالـ Protein Catabolism للـ Amino
+
+311
+00:31:49,460 --> 00:31:59,900
+Acids بدخّل الـ NH3 المشي اللي هو الـ الـ الـ الـ
+
+312
+00:31:59,900 --> 00:32:06,300
+Ammonia اللي هو Toxic ومش كويس وكذا الأصل أن تروح
+
+313
+00:32:06,300 --> 00:32:08,820
+إشي اسمه الـ Urea Cycle بحيث أنه بيطلع عند الـ
+
+314
+00:32:08,820 --> 00:32:15,680
+Urea اللي بيطلع في الـ Bowl فهذا بسببيعني مشاكل
+
+315
+00:32:15,680 --> 00:32:21,500
+ممكن يعمل أظنّي stones ممكن يعمل mental problem
+
+316
+00:32:21,500 --> 00:32:26,200
+ممكن يأثر على أشياء أخرى ماشوفتش حالات ما بعرف
+
+317
+00:32:26,200 --> 00:32:33,160
+عنها ففيه عنا إشي اسمه Uricicle defect أو enzymes
+
+318
+00:32:33,160 --> 00:32:38,340
+أو problems فإذا أعطيت حاجة اسمها Sodium Benzoate
+
+319
+00:32:39,050 --> 00:32:46,690
+سيحول مع الـGlycine والبنزوات الـUrea أسف الأمونيا
+
+320
+00:32:46,690 --> 00:32:53,110
+ستتحول لهيبيوريت الهيبيوريت هذا شغلي ممكن تخرج في
+
+321
+00:32:53,110 --> 00:32:59,950
+الـBowlفبالتالي أنا أخفف المرض وأمنع مشاكله وأجد
+
+322
+00:32:59,950 --> 00:33:07,030
+آلية أخرى للجسم وللـ «cell cycle» أو للجسم أنه
+
+323
+00:33:07,030 --> 00:33:12,150
+يخلص من الـ«product» الـ«toxic» الـ«product» اللي
+
+324
+00:33:12,150 --> 00:33:17,070
+بيكون «very high» بالنسبة لما يكون المرض موجود
+
+325
+00:33:17,070 --> 00:33:23,620
+ماشي، فهذا مثال على شيء نستفيد منهبالنسبة
+
+326
+00:33:23,620 --> 00:33:28,780
+للـFamilial Hypercholesterolemia Heterozygous شكله
+
+327
+00:33:28,780 --> 00:33:32,920
+الـHomozygous بيكون شديد كثير وما بعيشش أو كده أو
+
+328
+00:33:32,920 --> 00:33:36,280
+هيك فمن
+
+329
+00:33:36,280 --> 00:33:38,740
+ناحية الأمراض هذه اللي هو الـFamilial
+
+330
+00:33:38,740 --> 00:33:45,940
+Hypercholesterolemia الـHeterozygous بعد ما يعني
+
+331
+00:33:45,940 --> 00:33:56,210
+الـLDL Low Density Lipoproteinبتم أخذه بخلايا
+
+332
+00:33:56,210 --> 00:34:06,910
+الكبت ناشي مع الـ HMG هذا اللي هو الـ product تبع
+
+333
+00:34:06,910 --> 00:34:18,380
+اللي هويعني المادة مع الـ Coenzyme A بيكون الـ LDL
+
+334
+00:34:18,380 --> 00:34:22,940
+والمادة هذه بتحول له كوليسترول بيتم برضه إفرازه
+
+335
+00:34:22,940 --> 00:34:29,020
+ضمن الـ Bile Acid وبرجع مرة ثانية بدخل في الجسم
+
+336
+00:34:29,020 --> 00:34:35,180
+وبعدين محمول على LDL أو الكوليسترول بالذات الـ Low
+
+337
+00:34:35,180 --> 00:34:39,260
+Density اللي هو الكوليسترول السيء الـ High Density
+
+338
+00:34:39,260 --> 00:34:43,930
+Lipoproteinالـ high-density lipoprotein لأ، كويس
+
+339
+00:34:43,930 --> 00:34:47,550
+وعلى أكس، protective لو زاد، ما في مشكلة إذا كانت
+
+340
+00:34:47,550 --> 00:34:54,990
+زيادة منه فإذا أنت أعطيت دوة أو شيء بيمنع انتصاص
+
+341
+00:34:54,990 --> 00:35:00,930
+الـ bile acid وهي الشيء المطلوب حتى يتم انتصاص الـ
+
+342
+00:35:00,930 --> 00:35:05,350
+lipids بشكل عام الكوليسترول، الـ triglycerides الـ
+
+343
+00:35:05,350 --> 00:35:09,970
+fatty acids، أي شيء من هذا النوع بحاجة للواحد لـ
+
+344
+00:35:10,320 --> 00:35:17,660
+بيل أسد حتى يتم الـ absorption فإذا أنا أعطيت شيء
+
+345
+00:35:17,660 --> 00:35:24,160
+يوقف الـ absorption بقلل الـ LDL اللي بوجود في
+
+346
+00:35:24,160 --> 00:35:31,980
+الجسم وإذا حطيت برضه product that inhibit الـ
+
+347
+00:35:31,980 --> 00:35:36,180
+enzyme اللي بتأدى لتقليل الـ synthesis برضه
+
+348
+00:35:36,180 --> 00:35:43,160
+للكوليسترول في حالة ما يكون شديد كثيربرضه بتكون
+
+349
+00:35:43,160 --> 00:35:48,400
+آلية أخرى يعني فأحياناً نحتاج أنه ننزل الـ LDL
+
+350
+00:35:48,400 --> 00:35:56,920
+وهذه أمثلة على نتيجة فهمنا للـ «ميكانيزم»
+
+351
+00:35:56,920 --> 00:36:01,980
+والـ «ميتابوليزم» والأشياء هذه وكيف أنا أتدخل،
+
+352
+00:36:01,980 --> 00:36:06,160
+فإذا فيه «فميليلهايبركولستريميكهيتروزايجس» الـ
+
+353
+00:36:06,160 --> 00:36:12,110
+«hyperlipidemia» من هذا النوع الفميليلولو دخل بالـ
+
+354
+00:36:12,110 --> 00:36:21,970
+Premature Death وولو دخل بإنه يكون فيه مشكلة هنا
+
+355
+00:36:21,970 --> 00:36:29,650
+نتكلم عن الـ Marfan Syndrome برضه حكينا على إن الـ
+
+356
+00:36:29,650 --> 00:36:34,210
+«لو سرطان» بيحاولوا إنه يستفيدوا منه حتى يعالجوا
+
+357
+00:36:34,210 --> 00:36:37,710
+هذه الحالة ويعني
+
+358
+00:36:38,320 --> 00:36:46,800
+أول مرة بنتبه عليها وماعندي خبرة كبيرة فيها مارفان
+
+359
+00:36:46,800 --> 00:36:52,440
+سندروم بالأخر كلها Problem جينية بيصير خلل في
+
+360
+00:36:52,440 --> 00:36:58,360
+المادة والنسيج الضام فبصير صحيح الإنسان بيطلع طويل
+
+361
+00:36:58,360 --> 00:37:04,620
+كثير بس معرض إنه يصير عنده Subluxation يعني
+
+362
+00:37:04,620 --> 00:37:11,520
+الأطراف مرنة كثيربصير الـ High-arch palate بصير
+
+363
+00:37:11,520 --> 00:37:15,880
+الـ Lens dislocation إلى العيون و الـ Congenital
+
+364
+00:37:15,880 --> 00:37:22,380
+يعني أو الـ Aortic aneurysm الـ Dilatation of the
+
+365
+00:37:22,380 --> 00:37:28,560
+abdominal aorta كل هذه مظاهر و شكله أنه يعني هذا
+
+366
+00:37:28,560 --> 00:37:34,240
+من استخدامات هذه الأدوية في يعني بقالية معينة يعني
+
+367
+00:37:36,890 --> 00:37:45,350
+الاستخدام هنا يعني حسب اللي يعني بدل واحد يكون
+
+368
+00:37:45,350 --> 00:37:54,270
+يأخذ أحدث معلومة على أحدث شيء متفق عليه يعني
+
+369
+00:37:54,270 --> 00:38:04,610
+الأدوية من الأنواع الثانيةماشي، بالنسبة
+
+370
+00:38:04,610 --> 00:38:12,170
+لـ… يعني زي
+
+371
+00:38:12,170 --> 00:38:23,790
+ما في عندنا فهم أكبر لخطوات تنشيط أي protein معين
+
+372
+00:38:23,790 --> 00:38:33,880
+يعني دايماً نتكلمعن يعني غير الـ «Coding DNA» تبع
+
+373
+00:38:33,880 --> 00:38:37,920
+الـ «جين» تبع الـ «بروتين» المعين اللي نتكلم عنه
+
+374
+00:38:37,920 --> 00:38:46,200
+أحيانًا يعني من خلال فهم خلق الإنسان من خلال فهمنا
+
+375
+00:38:46,200 --> 00:38:50,920
+شو العوامل اللي بتخلي في الخلية هذه هذا الـ «جين»
+
+376
+00:38:50,920 --> 00:38:55,960
+يشتغلففي الغالب راح يكون يعني اللي هو بيسموهم زي
+
+377
+00:38:55,960 --> 00:39:03,640
+Growth Factors يعني Signal
+
+378
+00:39:03,640 --> 00:39:09,840
+Transduction Mechanisms لتنشيط مواقع معينة في الـ
+
+379
+00:39:09,840 --> 00:39:18,120
+DNAفلما يعرف الواحد الأليات هذه ممكن يحسن قضية
+
+380
+00:39:18,120 --> 00:39:23,840
+علاجها بشكل متخصص على إنه الأشياء اللي بدنا هي
+
+381
+00:39:23,840 --> 00:39:29,740
+سواء نرغب إنه نزيد أو نقصه حسب المرض أو حسب الحالة
+
+382
+00:39:29,740 --> 00:39:35,800
+يعني إذا كان المنتج هوالبروتين الفاسد المسبب للمرض
+
+383
+00:39:35,800 --> 00:39:41,440
+بدي لو فيه أقدر إنه المنشط لهذا البروتين أسكره
+
+384
+00:39:41,440 --> 00:39:49,440
+بكون خلصت المريض من هذا البروتين السيء يعني ففيه،
+
+385
+00:39:49,440 --> 00:39:54,660
+إذا بننتبه في حالة اسمها Hereditary Angioneurotic
+
+386
+00:39:54,660 --> 00:39:59,400
+Edema أو Hereditary Angioedema هذا من الأمراض اللي
+
+387
+00:39:59,400 --> 00:40:07,820
+أنا بتعامل معهامرض نادر جداً عبارة عن حالة الإنسان
+
+388
+00:40:07,820 --> 00:40:14,340
+بيصير يطلع عليه يعني وثمات وعائية زي ما بيقول
+
+389
+00:40:14,340 --> 00:40:19,520
+بالإنجليزي Angioedema من الأمراض الشائعة جداً
+
+390
+00:40:19,520 --> 00:40:24,380
+الناس بيصير عندهم Eurticaria Angioedema Eurticaria
+
+391
+00:40:24,380 --> 00:40:32,630
+اللي هي حالةيعني إن الإنسان بيكون عليه زي جارس
+
+392
+00:40:32,630 --> 00:40:39,850
+البعوض طفح مزعج بسبب الحكة زي جارس البعوض هذا
+
+393
+00:40:39,850 --> 00:40:44,490
+بنسميها «يورتيكاريا» الـ «يورتيكاريا» شائعة جدا
+
+394
+00:40:44,490 --> 00:40:50,160
+ويلها أسباب كثيرةتحسوس ومرات أمراض كبد أو أمراض
+
+395
+00:40:50,160 --> 00:40:55,480
+غضب درقية أو أمراض كلاب أو أمراض طفيليات أو
+
+396
+00:40:55,480 --> 00:40:59,560
+Parasitic Infection تعمل حساسي كذا، بس فيه نوعية
+
+397
+00:40:59,560 --> 00:41:07,400
+محددة عبارة عن حالة ورافية تزامل Dominant، وفيها
+
+398
+00:41:07,400 --> 00:41:14,370
+أكثر من نوعإنه فيه بروتين ضروري في الجسم اسمه «C1
+
+399
+00:41:14,370 --> 00:41:19,890
+Stress Inhibitor» اللي أخدته في الـ«إميونولوجيا»
+
+400
+00:41:19,890 --> 00:41:26,690
+تأثير أنه في عندي إنزايم مطلوب في الجسم اسمه «C1
+
+401
+00:41:26,690 --> 00:41:33,370
+Stress» يعني محطم الـ«C1» من مراكبات الـComplement
+
+402
+00:41:34,240 --> 00:41:40,400
+فهذا مرض النوعي الأساسي منه لأنه فيه أكتر من النوع
+
+403
+00:41:40,400 --> 00:41:45,120
+بيكون autosomal dominant المرضى بيجوا بأنجو ديما
+
+404
+00:41:45,120 --> 00:41:49,200
+بس، بيجوا بورم يعني بتلاقي إيديه بتورم، وجهه
+
+405
+00:41:49,200 --> 00:41:56,880
+بتورم، كذا، بيكون هذا المرض يعني بالذات التورمات
+
+406
+00:41:56,880 --> 00:42:01,130
+بتيجي على محلات الضرباتيعني أنا باتلاقين إلى أي
+
+407
+00:42:01,130 --> 00:42:06,270
+إنسان بشتكي من شري ووذمة وكذا بسأله هو ولا من أهله
+
+408
+00:42:06,270 --> 00:42:12,750
+أي واحد تكده صحله ضربة بورا مكانها هي بتكون مع C1
+
+409
+00:42:12,750 --> 00:42:20,870
+Stress Inhibitor فمن علاجات الـ Hereditary
+
+410
+00:42:20,870 --> 00:42:27,560
+Angioedema إذا ثبتتيعني بيكون الـ «C1» stress
+
+411
+00:42:27,560 --> 00:42:32,440
+level low بصراحة في عندنا دوة اسمها الـ «دانازول»
+
+412
+00:42:32,440 --> 00:42:37,480
+وفي بديل عنه طالع أجدد وأغلى شوية الـ «دانازول»
+
+413
+00:42:37,480 --> 00:42:43,740
+اللي هو نوع من قريب الـ«هرمون» الـ«سيكس هرمون»
+
+414
+00:42:43,740 --> 00:42:48,460
+الـreplacement أو كده بيلاحظوا أنه بس تحت المريض
+
+415
+00:42:48,460 --> 00:42:54,590
+النوبات هذه بتخف فالفكرةإنه زي ما انتوا شايفين في
+
+416
+00:42:54,590 --> 00:43:02,230
+الجدول الأول هو إنه الجين
+
+417
+00:43:02,230 --> 00:43:06,130
+المطلوب له زي «C1 Stress Inhibitor» في هذه الحالة
+
+418
+00:43:06,130 --> 00:43:13,930
+مثلا الـ «بروموتر ريجين» أنا يعني إذا كان هنا
+
+419
+00:43:13,930 --> 00:43:18,590
+المرض إنه مثلا بشتغلش ممكن أنا أحط إشي يخلّيه
+
+420
+00:43:18,590 --> 00:43:22,800
+يشتغل وأكون أثبت إنه بخلّيه يشتغلأو إذا كان هذا
+
+421
+00:43:22,800 --> 00:43:29,860
+مضرر وهو اللي عامل المرض باعطيه شيء يسوي له تسكير
+
+422
+00:43:29,860 --> 00:43:36,040
+عليه يعني
+
+423
+00:43:36,040 --> 00:43:41,480
+هذا مثال على شيءيعني نستخدمه سريريا وموجود
+
+424
+00:43:41,480 --> 00:43:49,260
+وبستخدمه وجربته وأنا شخصيا عندنا في الأردن هذا
+
+425
+00:43:49,260 --> 00:43:53,720
+الدواء موجود فقط بالخدمات الطبية الملكية وكل ما
+
+426
+00:43:53,720 --> 00:43:58,640
+أشخص حالي بهذه الطريقة يعني هم عدد قليل اللي
+
+427
+00:43:58,640 --> 00:44:04,760
+بشخصهم وفي الغالب مافيش تاريخ عائليويكون الإنسان
+
+428
+00:44:04,760 --> 00:44:08,360
+المصاب هو اللي صارت عنده الطفرة وهو أول واحد بيّن
+
+429
+00:44:08,360 --> 00:44:12,100
+عنده المرض يعني هذا اللي في الغالب بيكون هيك
+
+430
+00:44:12,100 --> 00:44:16,180
+فبوديهم على الخدمات وبيبعطوهم الدنازول وبتكون
+
+431
+00:44:16,180 --> 00:44:20,560
+أمرهم أهداً وهذا بيسوي Increase gene expression
+
+432
+00:44:20,560 --> 00:44:25,580
+from the wild type locus أو from mutant locus with
+
+433
+00:44:25,580 --> 00:44:31,940
+residual function يعني هي طريقة العمل هناإذا عندي
+
+434
+00:44:31,940 --> 00:44:38,320
+أنا يعني النظريات كيف هذا الدواء بيشتغل إنه «it is
+
+435
+00:44:38,320 --> 00:44:42,600
+almost dominant» يعني واحدة مصابة وواحدة طبيعية
+
+436
+00:44:42,600 --> 00:44:47,740
+وبيّن عنده المرض لأنه «dominant» فأحياناً لما أنا
+
+437
+00:44:47,740 --> 00:44:52,700
+أعطي الدواء هذا إذا بقى ليه معينة والمشكلة بتكون
+
+438
+00:44:52,700 --> 00:44:58,580
+في نقص الانزيم المطلوب بتلاقيها بتزوده أو بتقلل
+
+439
+00:44:58,580 --> 00:45:05,520
+المصابأو بتزيد حتى مستوى الـ يعني بتحسن مستوى
+
+440
+00:45:05,520 --> 00:45:10,680
+الوظيفة المطلوبة فيه اللي هو الـ DNA methylation
+
+441
+00:45:10,680 --> 00:45:20,960
+therapy with the ديستابين هذا الدواء يعني يمكن في
+
+442
+00:45:20,960 --> 00:45:24,750
+حالات معينة من الـ Sickle Cell Diseaseيعني إذا
+
+443
+00:45:24,750 --> 00:45:30,510
+بتذكروا الـ Sickle Cell اللي هو بالذات يعني لما
+
+444
+00:45:30,510 --> 00:45:39,370
+يكون فيه مشاكل جزء مهم من تحديد درجة الإصابة في
+
+445
+00:45:39,370 --> 00:45:44,690
+الـ Sickle Cell بتكون مستوى الـ Hemoglobin F الـ
+
+446
+00:45:44,690 --> 00:45:50,870
+Hemoglobin F، سبحان الله، إذا ظهر موجود يعني أنت
+
+447
+00:45:50,870 --> 00:45:57,850
+الـفي الغالب الإنسان بيقولوله SA يعني الـ
+
+448
+00:45:57,850 --> 00:46:04,690
+Hemoglobin تبعه اللي عنده … اللي إذا كان مصاب SS،
+
+449
+00:46:04,690 --> 00:46:10,070
+Sickle Cell Disease، ماشي؟ فيه Sickle Cell Carrier
+
+450
+00:46:10,070 --> 00:46:16,590
+SA، حتى المصابين لما نيجي نعمل حتى Protein
+
+451
+00:46:16,590 --> 00:46:20,910
+Electrophoresis أو Hemoglobin Electrophoresis
+
+452
+00:46:21,370 --> 00:46:25,910
+بنلاقي ممكن يعني لأنه في فترة في حياة الإنسان كان
+
+453
+00:46:25,910 --> 00:46:29,350
+عنده Hemoglobin-F مش الـHemoglobin من هذا النوع
+
+454
+00:46:29,350 --> 00:46:38,110
+فالملاحظ أنه لو إنسان ضال عنده إنتاج للـHemoglobin
+
+455
+00:46:38,110 --> 00:46:45,130
+-F نسبة أكبر بيصير المرض أخف والسبب أنه كل ما
+
+456
+00:46:45,130 --> 00:46:51,630
+ارتفع كمية الـHemoglobin-Fفي خلايا الدم الحمراء
+
+457
+00:46:51,630 --> 00:46:56,350
+الـ Cycling Phenomena بتقل ما بتحدث بنفس الطريقة
+
+458
+00:46:56,350 --> 00:47:02,050
+فبالتالي إذا حطينا
+
+459
+00:47:02,050 --> 00:47:09,510
+إشي بقالية معينة يعني زودنا نسبة الـ Hemoglobin F
+
+460
+00:47:09,510 --> 00:47:14,770
+طبعاً بدي يكون Hemoglobin F في جوا خلايا الدم
+
+461
+00:47:14,770 --> 00:47:22,740
+الحمراء يعنيلازم نتدخّل أو بقالية معينة نصل إلى
+
+462
+00:47:22,740 --> 00:47:27,720
+نفس الخلايا المصابة ونحاول أن نغيّر فيها الـ
+
+463
+00:47:27,720 --> 00:47:31,520
+Hemoglobinopathies والـ Sickle Cells وكذا بشكل
+
+464
+00:47:31,520 --> 00:47:36,100
+عام، يعني بالذات إذا كان مكان متقدم الطب فيه
+
+465
+00:47:36,100 --> 00:47:44,540
+وبالذات إذا شخصوا الحالة مبكراً وتم يعني
+
+466
+00:47:46,870 --> 00:47:50,710
+بالتفكير والتدخل، إذا كان هناك خبرة أو إمكانات أو
+
+467
+00:47:50,710 --> 00:47:58,060
+شيء آخر قبل أن يُعطى الإنسان نقل دم بشكل كبيريعني
+
+468
+00:47:58,060 --> 00:48:03,620
+أول علاج سريع لما بتكون فيه أزمة و Crisis ومشاكل
+
+469
+00:48:03,620 --> 00:48:10,480
+أنه نعطي دم بيحسن المريض عرضياً بشكل أعراضه يعني
+
+470
+00:48:10,480 --> 00:48:13,960
+الـ Anime بيخففها الـ Sickle Cell Episode بيخففه
+
+471
+00:48:13,960 --> 00:48:20,320
+بيعمل تحسين للمريض يعني فالنقل
+
+472
+00:48:20,320 --> 00:48:24,700
+للمخاع العظم ماشي للـ Thalassemia أو الـ
+
+473
+00:48:24,700 --> 00:48:30,730
+Hemoglobinopathiesواللي راح ناخد بعد شوية اللي هم
+
+474
+00:48:30,730 --> 00:48:36,770
+الأمراض نقصان المناعة الأولية الـ Primary Immune
+
+475
+00:48:36,770 --> 00:48:40,330
+Deficiencies زي الـ Severe Combined Immune
+
+476
+00:48:40,330 --> 00:48:45,950
+Deficiency، الـ SCID هدولة إذا الواحد بقدر يعمل
+
+477
+00:48:45,950 --> 00:48:49,250
+Boomer Transplantation أو تمثل Transplantation من
+
+478
+00:48:49,250 --> 00:48:56,800
+إنسان قريب بكون كويس، بس أحيانًا إذا تمإعطاء يعني
+
+479
+00:48:56,800 --> 00:49:01,620
+لما يكون فيه نقفة منع عادة ما في مشكلة ما بنفش
+
+480
+00:49:01,620 --> 00:49:05,000
+داعي لدمة أو لا شيء محدد من قبل زاد إنه نفس
+
+481
+00:49:05,000 --> 00:49:09,500
+الإنسان منعته بعيفة ما بتخليه يقدر يرفض العضو اللي
+
+482
+00:49:09,500 --> 00:49:12,520
+ماعطيه له، مش عارف؟ بس بالنسبة
+
+483
+00:49:12,520 --> 00:49:17,260
+للـHemoglobinopathies إذا تم إعطاء الدم مرات كثيرة
+
+484
+00:49:17,260 --> 00:49:23,360
+إلا كل مرة بكون في بعض خلايا الدم البيضاء أو بعض
+
+485
+00:49:23,360 --> 00:49:31,780
+الـAntigensزي مثال مثلًا حتى لو بشكل نادر للـRare
+
+486
+00:49:31,780 --> 00:49:37,840
+Blood Groups كأنه أعطانا إنسان زي ما بنعطي زي ما
+
+487
+00:49:37,840 --> 00:49:42,120
+يحصل مع المرأة الحامل بالـRH Incompatibility إنه
+
+488
+00:49:42,120 --> 00:49:47,240
+يكون الجنين
+
+489
+00:49:47,240 --> 00:49:51,890
+الأول اللي أتلقاه Positiveبيكون الجنين الأول
+
+490
+00:49:51,890 --> 00:49:55,510
+بيعدّي وما فيش مشكلة بس بعدين لما يصير
+
+491
+00:49:55,510 --> 00:49:59,850
+الـSensitization ما بيظل الجنين الثالث أو الرابع
+
+492
+00:49:59,850 --> 00:50:10,910
+بيصير تجهد كل ما يتم حمل يعني فالفكرة أنه إذا بدنا
+
+493
+00:50:10,910 --> 00:50:16,930
+نقل نقاع عضم لزي هذه المشكلة اللي هي الـHemoglobin
+
+494
+00:50:16,930 --> 00:50:22,070
+Abortaseلازم يعمل بشكل مبكر لازم يعمل قبل ما يُعطى
+
+495
+00:50:22,070 --> 00:50:27,530
+المريض عدد كبير من نقل الدم ويقال عليه عملية
+
+496
+00:50:27,530 --> 00:50:31,890
+الـUnlaw Immunization بيصير المناعة منشطة كثير
+
+497
+00:50:31,890 --> 00:50:37,050
+بحيث أنها ترفض نقل الدم وبالتالي تصير مشاكل فبديل
+
+498
+00:50:37,050 --> 00:50:41,450
+آخر لما ما يكون عنده إمكانية لهذا النوع العلاج
+
+499
+00:50:41,450 --> 00:50:49,340
+الأكثر أنه أنا أعدل درجة الـDNA methylationمع دوة
+
+500
+00:50:49,340 --> 00:50:53,040
+مثل ديستابين
+
+501
+00:50:53,040 --> 00:50:58,380
+لزيادة الـ hemoglobin F اللي بيحسن الـ Sickle Cell
+
+502
+00:50:58,380 --> 00:51:05,900
+على الأقل مظهريًامع اللي إذا بننتبه للسهم الرابع
+
+503
+00:51:05,900 --> 00:51:10,640
+اللي هو الـ Gene Therapy زي الـ X-Linked Severe
+
+504
+00:51:10,640 --> 00:51:13,760
+Combined Immune Deficiency زي اللي هو الـ
+
+505
+00:51:13,760 --> 00:51:18,960
+Adenosine Deaminase Deficiency أحيانًا إذا في نقص
+
+506
+00:51:18,960 --> 00:51:26,700
+إنزين معين بالذات في قضية نقل النخاع العظم فهو من
+
+507
+00:51:26,700 --> 00:51:35,620
+ناحيةتقنية من ناحية procedure خفيف وبسيط وسهل جداً
+
+508
+00:51:35,620 --> 00:51:41,200
+يعني ما بدوش تعقيدات كثيرة يعني ينقل في جسم المصاب
+
+509
+00:51:41,200 --> 00:51:45,680
+عن طريق نقل الدم يعني هيك زي نقل الدم لما أنقل أنا
+
+510
+00:51:45,680 --> 00:51:52,640
+نخاع عظم نخاع العظم من المتبرع بنيجي وبنخدره
+
+511
+00:51:52,640 --> 00:51:57,540
+وبنيجي على العظام الكبيرة فيه عظام الحوض مثلاً
+
+512
+00:51:57,910 --> 00:52:04,690
+بالذات بإبر كبير كثير مرات كثيرة بنسحب نقاء العظم
+
+513
+00:52:04,690 --> 00:52:08,550
+من الإنسان الطبيعي فبتطلع لنا كمية بتكون شبيهة
+
+514
+00:52:08,550 --> 00:52:14,510
+بوحدة الدم بحيث إنه نقلها للإنسان المصاب بكون عن
+
+515
+00:52:14,510 --> 00:52:20,490
+طريق نقل دم عادي والخلايا الجذعية والخلايا النقاء
+
+516
+00:52:20,490 --> 00:52:24,370
+العظم بتعرف تندل ترجع عن طريق الدم لنقاء العظم
+
+517
+00:52:24,370 --> 00:52:24,850
+تبعها
+
+518
+00:52:30,600 --> 00:52:39,060
+ففي أليات أخرى زي إنه نعطي Small Inactive RNA
+
+519
+00:52:39,060 --> 00:52:45,980
+Segments يعني عبارة عن إن أنا أعطي
+
+520
+00:52:45,980 --> 00:52:56,430
+إشي يؤثر على إنه يخرّب أو يقلل الـMessenger RNAكل
+
+521
+00:52:56,430 --> 00:53:03,210
+المشاكل اللي يعني بذكر مرة ثانية يعني في بعض
+
+522
+00:53:03,210 --> 00:53:09,230
+الأشياء أنا عندي خبرة فيها شوية ويعني راح نتفرج
+
+523
+00:53:09,230 --> 00:53:13,550
+على كثير من الأشياء بعدين بحطولك أنثى على إنه
+
+524
+00:53:13,550 --> 00:53:18,170
+تجربة قام وبيعملها وكانت النتيجة نص نص، كويسة
+
+525
+00:53:18,170 --> 00:53:22,710
+كثير، كويسة بشكل واضح، كده وتلاقي شغلات عبارة عن
+
+526
+00:53:22,710 --> 00:53:27,920
+عمليات دراسيةالـ «Messenger RNA» جوا الخلية صعب أن
+
+527
+00:53:27,920 --> 00:53:35,300
+الواحد يغيره وكانت تعطي حتى لو ما بستطيعش أني مثلا
+
+528
+00:53:35,300 --> 00:53:41,500
+أجيب حب الدواء المريض يأخذه أو حتى إذا إشي صعب أنه
+
+529
+00:53:41,500 --> 00:53:47,740
+يكون عن طريق الفم حتى عن طريق الوريد لو دخلته جوا
+
+530
+00:53:47,740 --> 00:53:57,340
+الجسم بشكل حقن أو بالوريدليس بالضرورة إنه يكون
+
+531
+00:53:57,340 --> 00:54:04,600
+مفيد إنه بدّك الدواء هذا يصل جوا الخلايا لحيث إنه
+
+532
+00:54:04,600 --> 00:54:10,700
+يعني أو بالذات إذا الـMolecule كبير وComplex وكذا
+
+533
+00:54:10,700 --> 00:54:18,520
+الجسم بحكمه وما بسمحله يدخل جوا الخلية فقضية
+
+534
+00:54:18,520 --> 00:54:25,570
+زي الـTrans Tyreneالـ Trans-thyretine في الـ
+
+535
+00:54:25,570 --> 00:54:34,390
+Amyloidosis يعني نوع من استخدام الـ RNA لتعديل على
+
+536
+00:54:34,390 --> 00:54:37,550
+مستوى الـ expression أو الـ function of the
+
+537
+00:54:37,550 --> 00:54:43,930
+messenger RNA أحياناً في
+
+538
+00:54:43,930 --> 00:54:52,820
+بعض الأدوية لأنه لما يكون عندي أنا جزء من الـالـ
+
+539
+00:54:52,820 --> 00:54:58,800
+Pathology جزء من تسبب المرض أنه الـ يعني زي ما
+
+540
+00:54:58,800 --> 00:55:03,220
+تقوله مثلاً كيف الفرق بين الـ الـ Hemoglobin
+
+541
+00:55:03,220 --> 00:55:06,540
+العادى الـ Beta Chain والـ Cycling الـ Beta Chain
+
+542
+00:55:06,540 --> 00:55:11,200
+في حالة الـ Sickle Cell Disease أنه الـ Sickle
+
+543
+00:55:11,200 --> 00:55:17,160
+Cell Disease الـ Mutant Protein الـ Abnormal
+
+544
+00:55:17,160 --> 00:55:21,960
+Protein فيه قلوب ميزة بتخليه ما يشتغلش مظبوط
+
+545
+00:55:23,250 --> 00:55:26,990
+فمثلًا، إيشي مكان المفروض يكون مفتوح، صار عندي
+
+546
+00:55:26,990 --> 00:55:32,650
+folding بطريقة مختلفة وسكر، فإذا عندي دوة أو شيء
+
+547
+00:55:32,650 --> 00:55:39,010
+بقدر أخلي المكان المفتوح يظل مفتوح وما يسكرش، ممكن
+
+548
+00:55:39,010 --> 00:55:50,750
+هذايكون مفيد يعني فهذا فيه دوة «Luma Saptor» «Luma
+
+549
+00:55:50,750 --> 00:55:56,690
+Saptor» اللي هو «Stabilizes Reformed» اللي هو
+
+550
+00:55:56,690 --> 00:56:05,210
+«Delta F508» في مرض معين يعني فهي كلها أمثل إلى
+
+551
+00:56:05,210 --> 00:56:10,090
+أدوي وأشياءالـ Cystic Fibrosis وهنا أحنا، يعني
+
+552
+00:56:10,090 --> 00:56:12,550
+يمكن هيك كثير من الأمثلة بتيجي على الـ Cystic
+
+553
+00:56:12,550 --> 00:56:17,350
+Fibrosis الممكن
+
+554
+00:56:17,350 --> 00:56:22,850
+أنا يعني أعطي أدوية تساعد الـ Protein Replacement
+
+555
+00:56:22,850 --> 00:56:26,950
+يعني بعد ما نوصل يعني ممكن الـ Folding ممكن أنا
+
+556
+00:56:26,950 --> 00:56:33,570
+أعطي شيء يـMaintain it البروتين اللي اتكون هذا
+
+557
+00:56:33,570 --> 00:56:37,930
+أحياناًبكون معقد وفي أشياء كثيرة وانا مثال على
+
+558
+00:56:37,930 --> 00:56:42,470
+«سيستيكفايبروسيس» «Systic Fibrosis Transporter
+
+559
+00:56:42,470 --> 00:56:50,870
+Receptor» وهو نقله أكثر من الـ «domain» وعبارة عن
+
+560
+00:56:50,870 --> 00:56:57,230
+«gate» للـ «onion exchange» فبالتالي، إذا أنا
+
+561
+00:56:57,230 --> 00:57:07,290
+قلاقي أدويةبتحسن وظيفة الـ Protein هذا ممكن أنا
+
+562
+00:57:07,290 --> 00:57:12,550
+مرض زي الـ Cystic Fibrosis أحسنه الفيموفيليا بيكون
+
+563
+00:57:12,550 --> 00:57:15,290
+إنه أنا بعمل protein replacement with native
+
+564
+00:57:15,290 --> 00:57:21,370
+protein زي هنا أو إنه الـ Goucher Disease أو
+
+565
+00:57:21,370 --> 00:57:25,500
+Fabric Disease من الـ Metabolicيعني الـ Diseases
+
+566
+00:57:25,500 --> 00:57:30,340
+الـ ERT برضه ممكن أنا أعطيه بروتيل مرات مع أنه
+
+567
+00:57:30,340 --> 00:57:34,780
+المفروض يشتغل جوا خلايا بس إذا بيعطيه بالدم ممكن
+
+568
+00:57:34,780 --> 00:57:40,540
+أحيانًا أحسن المرض يعني بالحالة هذه أحيانًا بنسوي
+
+569
+00:57:40,540 --> 00:57:45,380
+الـ Replacement بـ Modified Protein ماشي الـ
+
+570
+00:57:45,380 --> 00:57:53,290
+Regulation يعني الـ Big هذه نسيت اختصار لإيشفي
+
+571
+00:57:53,290 --> 00:57:58,830
+أحيانًا أدوية وحالات
+
+572
+00:57:58,830 --> 00:58:05,870
+مثلًا في الكثير مثلًا الإتهاب الكبد والوباء الـ C
+
+573
+00:58:05,870 --> 00:58:11,730
+الهي بتاعة الـ C فيروس وإلا عندي أنا مثلًا chronic
+
+574
+00:58:11,730 --> 00:58:15,590
+granulomatous disease أوفي حالات عندي زي الـ
+
+575
+00:58:15,590 --> 00:58:20,550
+Anchor Cell Deficiency «طبيعي خطر الخطر» في من
+
+576
+00:58:20,550 --> 00:58:26,250
+الأدوية دواب عبارة عن هرمون في المناعة تفرز الجسم
+
+577
+00:58:26,250 --> 00:58:29,150
+في مرحلة معينة في مقاومة الفيروسات اسمه الـ
+
+578
+00:58:29,150 --> 00:58:35,830
+Interferon فالـ Interferon الطبيعي
+
+579
+00:58:35,830 --> 00:58:39,890
+اللي أول ما صنعوه لما
+
+580
+00:58:42,220 --> 00:58:46,720
+بأعطيه في جسم الإنسان بأعطيه حقنة للإنسان هذا
+
+581
+00:58:46,720 --> 00:58:53,300
+ميزته صحيح، مؤثر و بـFeel بس برتفع كثير و بختفي
+
+582
+00:58:53,300 --> 00:58:57,800
+بسرعة فبتم يعني الـ «metabolism» و الـ «half-life»
+
+583
+00:58:57,800 --> 00:59:04,620
+تبع الدراج أو تبع الهرمون هذا سريع كثير فعملية الـ
+
+584
+00:59:04,620 --> 00:59:11,310
+«bigelation» عملية الـ «big interferon»هي عبارة عن
+
+585
+00:59:11,310 --> 00:59:18,330
+إضافة مُركّب آخر على الـ Interferon بحيث أنه بيطول
+
+586
+00:59:18,330 --> 00:59:22,550
+عمره وبيخلّي الـ Half-Life أطول وبيخلّي تأثير
+
+587
+00:59:22,550 --> 00:59:27,010
+الدواء يستمر لمدة أطول فعملية الـ Pegylation هي
+
+588
+00:59:27,010 --> 00:59:31,190
+عبارة عن Modification للبروتين التبع الدواء
+
+589
+00:59:31,190 --> 00:59:38,430
+وأحيانًا بنستفيد منها في خاصية هذه إنه بتخلّي الـ
+
+590
+00:59:39,150 --> 00:59:43,130
+الـ Enzyme أو الـ «هورمون» أو الـ «دراج» اللي
+
+591
+00:59:43,130 --> 00:59:49,590
+مطلوب بتخلّي مدته في الجسم طويلة ففي حالات الـ ADA
+
+592
+00:59:49,590 --> 00:59:53,470
+Deficiency اللي هو الـ «دينوسين دي أميناس»
+
+593
+00:59:53,470 --> 00:59:57,950
+الـEnzyme اللي في حالات الـSevere Combined Immune
+
+594
+00:59:57,950 --> 01:00:04,610
+Deficiency الحالات اللي هي نخس المناعة الـ
+
+595
+01:00:06,240 --> 01:00:09,880
+للـ T و الـ B-cells يعني الـ Combined الـ Both
+
+596
+01:00:09,880 --> 01:00:17,160
+خلال المناعة المكتسبة أو المناعة المتخصصة اللي هم
+
+597
+01:00:17,160 --> 01:00:20,440
+الـ T و الـ B-Lymphocytes أثنين هم بيكونوا قليلين
+
+598
+01:00:20,440 --> 01:00:27,580
+و مش شغالين و بيصير عندنا أمراض كثيرة فهذه لما أنا
+
+599
+01:00:27,580 --> 01:00:36,240
+أعطي الـ Big ADAممكن أنه يحسن الوضع ماعندي خبرة في
+
+600
+01:00:36,240 --> 01:00:43,680
+الحالات هذه يعني الـSCID أنا بعرف أنه أهم شيء لهم
+
+601
+01:00:43,680 --> 01:00:49,620
+لما يكون فيه تشخيص مبكر أنه يتم عملية نقل نخبع
+
+602
+01:00:49,620 --> 01:00:56,670
+العضم من شخص قريببشكل مفيد وراح نحكي عن آليات أخرى
+
+603
+01:00:56,670 --> 01:01:03,770
+إذا ما توفر donor كويس ممكن الواحد يعني يأخذ الـ
+
+604
+01:01:03,770 --> 01:01:08,010
+Pomero تبع الأو خلايا نفس المريض عدّلها جينياً في
+
+605
+01:01:08,010 --> 01:01:12,370
+المختبر ويرجع لها هي مرة ثانية يعني قضية الـ
+
+606
+01:01:12,370 --> 01:01:15,710
+Pomero للآن الـ Hemoglobinopathies
+
+607
+01:01:17,880 --> 01:01:21,220
+الـ Immune Deficiencies الـ Primary Immune
+
+608
+01:01:21,220 --> 01:01:25,980
+Deficiencies هي الأشياء اللي يعني مقبولة ومعروف
+
+609
+01:01:25,980 --> 01:01:33,500
+أنها بتوفر وبتفيد وكويسة الـ Other types of
+
+610
+01:01:33,500 --> 01:01:38,700
+disease treatment اللي هو زي الـ Cofactor أو زي
+
+611
+01:01:38,700 --> 01:01:43,320
+الـ Vitamin B6 اللي هو سيستينيوريا بتكون برضه ممكن
+
+612
+01:01:43,320 --> 01:01:49,710
+استفيد منها فهذه أمثلةلـ Molecular Treatments لـ
+
+613
+01:01:49,710 --> 01:01:55,750
+Genetic Diseases وهي بعض الأليات والأفكار بالنسبة
+
+614
+01:01:55,750 --> 01:02:01,110
+للعلاجات هو أنا بدي أثبت إنه دراسة معينة على حالة
+
+615
+01:02:01,110 --> 01:02:10,050
+معينة لما أعطوا الدواء هذا هنا دراسة تعتبر نسبياً
+
+616
+01:02:10,050 --> 01:02:18,280
+كبيرة على 83 حالة، ضالهم لحد 77 حالةكيف أنه يعني
+
+617
+01:02:18,280 --> 01:02:23,620
+في مقابل سبعين حالة مااخدوش الدواء أو أخدوا المادة
+
+618
+01:02:23,620 --> 01:02:30,480
+الخاملة شوية سكر اللي هو Ivacaftor
+
+619
+01:02:30,480 --> 01:02:37,500
+اللي هو كليدوليكون في الـ Cystic Fibrosis ده حكينا
+
+620
+01:02:37,500 --> 01:02:42,160
+عن إنه كيف هذا بيشتغل وكده بس يعني ماعندي خبرة
+
+621
+01:02:42,160 --> 01:02:44,560
+وماشوفتش إشي زي هيك
+
+622
+01:02:47,550 --> 01:02:54,450
+يعني هذا يجعل الواحد يتذكر الأمثل الأكبر اللي
+
+623
+01:02:54,450 --> 01:02:59,830
+أعطيناهم إياها بس يعني الواحد يلاحظ كثير من
+
+624
+01:02:59,830 --> 01:03:05,510
+الأشياء Investigational يعني هذه كلها إبارة عن
+
+625
+01:03:05,510 --> 01:03:11,120
+أمثلة على أدوية في لسة مراحل الدراسةأحيانًا، يعني
+
+626
+01:03:11,120 --> 01:03:15,400
+ممكن يثبت أن الدواء حتى هو أسوأ من المرض ويقتل
+
+627
+01:03:15,400 --> 01:03:19,140
+المريض بشكل أسرع بالـ Side Effect تبع الدواء
+
+628
+01:03:19,140 --> 01:03:25,080
+أحيانًا والشغل الثاني، مشكلة توفر هذه الأدوية وذات
+
+629
+01:03:25,080 --> 01:03:30,840
+أنها Very Expensive فحتى هذا الدواء يعني مثلًا
+
+630
+01:03:30,840 --> 01:03:34,300
+حاطين عنه Expensive إذا هم حاطين Expensive يبقى
+
+631
+01:03:34,300 --> 01:03:43,280
+Very Very Expensive ففيه يعنيمجال أو فيه احتمالية
+
+632
+01:03:43,280 --> 01:03:55,300
+إن الواحد يعني من خلال فهمه للقليات التحكم بالـ
+
+633
+01:03:55,300 --> 01:04:03,080
+Expression للجيل في تكوين البروتين يعني هذول
+
+634
+01:04:03,080 --> 01:04:09,940
+الأدوية بهذا الشكل المتخصصعبارة عن إذا ثبت وإذا تم
+
+635
+01:04:09,940 --> 01:04:13,720
+إكتشافه
+
+636
+01:04:13,720 --> 01:04:22,280
+وتجريبه إنه ما لهوش أثار جانبية وكويس بتلاقي بيكون
+
+637
+01:04:22,280 --> 01:04:28,160
+إشي يعني مفيد جداً ورائع جداً يعني هذه مبادئ
+
+638
+01:04:28,160 --> 01:04:35,390
+التغيير في الـفي الـ Gene Expression على مستوى حيث
+
+639
+01:04:35,390 --> 01:04:45,270
+أنه بشكل متخصص والأمر بربط بشكل كبير أحيانًا في
+
+640
+01:04:45,270 --> 01:04:50,250
+هذه المواضيع بفكرة الـ Signal Transduction في الـ
+
+641
+01:04:50,250 --> 01:04:56,350
+Controlيعني الدواء مهم كثير مثلًا لنقل الأعضاء الـ
+
+642
+01:04:56,350 --> 01:05:02,370
+«cyclosporin» بيشتغل على ميكانزم لتنشيط الـ
+
+643
+01:05:02,370 --> 01:05:06,770
+«interlocking tube» اللي مطلوب لوظيفة الـ «T-cell»
+
+644
+01:05:06,770 --> 01:05:12,830
+بحيث أنه بخلي الجسم يتقبل نقل العظم، نقل الأعضاء
+
+645
+01:05:12,830 --> 01:05:17,830
+حتى لو مافيش تطابق بإنه نمنع المناعة إنها تشتغل
+
+646
+01:05:18,320 --> 01:05:23,080
+فحكينا على الـ Vitamin B6 في الـ «بيردوكسين
+
+647
+01:05:23,080 --> 01:05:27,320
+رسبونسيف هموسستينيوريا» الـ Homocystinuria مرض
+
+648
+01:05:27,320 --> 01:05:33,100
+برضه بيصير إفراز الـ «Homocystin» وزيادة فيه في
+
+649
+01:05:33,100 --> 01:05:37,060
+الدم وفي الـBall أحيانًا ففيه نوعية منه «Bioduccin
+
+650
+01:05:37,060 --> 01:05:43,050
+Responsive» وشكلهلأنه بيشتغل كـ «فايتامين» كـ Co
+
+651
+01:05:43,050 --> 01:05:51,430
+-Factor لـ Enzyme فبحسم لما نزيد المستوى ففي
+
+652
+01:05:51,430 --> 01:05:55,050
+خمسين بالمائية من الحالات الـ Responsive تانية،
+
+653
+01:05:55,050 --> 01:06:00,290
+هذي بيكون ميوتاشنز مختلفة وبتكون أشياء بتفيد الـ
+
+654
+01:06:00,290 --> 01:06:06,630
+Protein Augmentation حكينا عن الـ «فاكتور 8» أو
+
+655
+01:06:06,630 --> 01:06:10,410
+أحيانا «فاكتور 9»والـ «established» و «effective»
+
+656
+01:06:10,410 --> 01:06:13,670
+و «safe» وما عدا أحياناً كانوا زمان
+
+657
+01:06:13,670 --> 01:06:19,070
+«cryoprecipitate» يعني يجيبون من البني أدمين فكان
+
+658
+01:06:19,070 --> 01:06:27,410
+يصير مرات قضية يعني إنه ما يقدروش يفصلوا كل
+
+659
+01:06:27,410 --> 01:06:31,670
+الأمراض المعضية فكان الـ «Hepatitis B» وحتى الـ
+
+660
+01:06:31,670 --> 01:06:37,790
+«HIV» وكذا يكون موجودالـ Recombinant DNA
+
+661
+01:06:37,790 --> 01:06:42,350
+Technology الـ Recombinant يعني إنه الجين اللي
+
+662
+01:06:42,350 --> 01:06:46,910
+بديه أو البروتين اللي بديه أخلي زي الإنسليل مثلاً
+
+663
+01:06:46,910 --> 01:06:51,570
+أخلي البكتيريا هي اللي تصنعه عن طريق أن أعزل الجين
+
+664
+01:06:51,570 --> 01:06:56,930
+تبعه أحطه على بلازمد أو فكتر من الفيروس نحقنه
+
+665
+01:06:56,930 --> 01:07:00,330
+بالبكتيريا، نعطي البكتيريا الأكل بتصير هي تنتج
+
+666
+01:07:00,330 --> 01:07:04,230
+منها مزرعة البروتين اللي أنا بديه أعزله وبعدين
+
+667
+01:07:04,230 --> 01:07:10,930
+برجع أعطيه للناسهذه الفكرة كاتبين إنه ممكن نستفيد
+
+668
+01:07:10,930 --> 01:07:17,230
+منها في الـ ADA SCID اللي هو Severe Combined
+
+669
+01:07:17,230 --> 01:07:21,290
+Immune
+
+670
+01:07:21,290 --> 01:07:26,050
+Deficiency وهي هو يمكن إن أنا معلومة ماكنتش عارفها
+
+671
+01:07:26,050 --> 01:07:34,340
+كثير إنه الدواء هذا بالطريقة هذهمؤقتًا تستخدم
+
+672
+01:07:34,340 --> 01:07:38,080
+لتحسين
+
+673
+01:07:38,080 --> 01:07:42,000
+وضع المريض حتى يتحمل الـ HLA-Bomber
+
+674
+01:07:42,000 --> 01:07:49,860
+Transplantation يعني مفيد مؤقتًا عبارة عن النسق
+
+675
+01:07:49,860 --> 01:07:56,240
+لعملية نقل النخاع عظم بعدها لهذه الحالة الـ
+
+676
+01:07:56,240 --> 01:07:58,600
+Goutier Disease
+
+677
+01:08:01,020 --> 01:08:06,440
+يعني هو من الأمراض برضه الـ Nervous System برضه
+
+678
+01:08:06,440 --> 01:08:13,480
+Beta-Glucose Reprosidase Deficiency فأنا بعوض الـ
+
+679
+01:08:13,480 --> 01:08:18,860
+Protein هذا يعني أظن أنه مطلوب مش ذاكر في الـ
+
+680
+01:08:18,860 --> 01:08:26,360
+Bomber ولا في الـيعني مطلوب يكون في الـ «nervous
+
+681
+01:08:26,360 --> 01:08:30,860
+system» أو بيكفّي الكبد لأن الكبد هو أهم واحد للـ
+
+682
+01:08:30,860 --> 01:08:38,340
+«metabolism» بشكل عام يعني فأحيانًا يعني بيكون إذا
+
+683
+01:08:38,340 --> 01:08:47,180
+حد بعرف مثل الإكحالات أنه ممكن يكون بتكون
+
+684
+01:08:47,180 --> 01:08:52,190
+هي نوع من الأدوية المفيدةأحيانًا أنا بعدل في وظيفة
+
+685
+01:08:52,190 --> 01:09:18,970
+الـ’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’�
+
+686
+01:09:19,250 --> 01:09:24,390
+يتكوّن الإنزايم الكامل فأحيانًا إذا في عندى
+
+687
+01:09:24,390 --> 01:09:29,510
+mutation بحيث إنه على الـ «level» العادى من الـ
+
+688
+01:09:29,510 --> 01:09:36,890
+«vitamin cofactor» بيكون إنه نسبة الإنزايم الكامل
+
+689
+01:09:36,890 --> 01:09:41,910
+قليلة السبب إن هذا الـ «cofactor» لما بيشتغل هنا
+
+690
+01:09:41,910 --> 01:09:47,110
+ما بيعطينا functional very good result
+
+691
+01:09:47,930 --> 01:09:52,750
+بينما لما أنا أزيد الـ «vitamin cofactor level»
+
+692
+01:09:52,750 --> 01:09:57,170
+بشكل كبير كثير عندما أعطي جرع عالي جدًا في الحالة
+
+693
+01:09:57,170 --> 01:10:04,830
+هذه يعني بنجبر الـ «cofactor» على إنه يلتصق بالـ
+
+694
+01:10:04,830 --> 01:10:11,810
+حتى الـ «muted» الـ «apoenzyme» بحيث إنه يعني يحسن
+
+695
+01:10:11,810 --> 01:10:18,270
+نسبة وظيفة الـ «enzyme» المطلوببحيث إنه بيخفف من
+
+696
+01:10:18,270 --> 01:10:27,210
+المرض فهذه أمثلة يعني على الأمراض
+
+697
+01:10:27,210 --> 01:10:32,050
+والحالات وأمثلة
+
+698
+01:10:32,050 --> 01:10:39,310
+عليها يعني الملاحظ في أفكار جميلة كثير في أفكار
+
+699
+01:10:39,310 --> 01:10:45,260
+يعني كيف الواحد يعالج يخلص من المشاكلأحيانًا تعويض
+
+700
+01:10:45,260 --> 01:10:51,000
+البروتين نفسه أحيانًا تعديل إذا شيء بيساعد على إن
+
+701
+01:10:51,000 --> 01:11:01,700
+المرض ما يظهر كدا وهنا يعني بيكرروا نفس الأفكار
+
+702
+01:11:01,700 --> 01:11:08,950
+لأن كثير منها من الأشياءحاطين Investigational
+
+703
+01:11:08,950 --> 01:11:13,670
+وInvestigational مبسوطين هنا على أنه «سهل» «تجارب
+
+704
+01:11:13,670 --> 01:11:14,850
+التجارب التجاربية التجاربية التجاربية التجاربية
+
+705
+01:11:14,850 --> 01:11:14,970
+التجاربية التجاربية التجاربية التجاربية التجاربية
+
+706
+01:11:14,970 --> 01:11:16,290
+التجاربية التجاربية التجاربية التجاربية التجاربية
+
+707
+01:11:16,290 --> 01:11:18,210
+التجاربية التجاربية التجاربية التجاربية التجاربية
+
+708
+01:11:18,210 --> 01:11:20,310
+التجاربية التجاربية التجاربية التجاربية التجاربية
+
+709
+01:11:20,310 --> 01:11:20,310
+التجاربية التجاربية التجاربية التجاربية التجاربية
+
+710
+01:11:20,310 --> 01:11:26,110
+التجاربية التجاربية التجاربية التجاربية التجاربية
+
+711
+01:11:26,110 --> 01:11:36,970
+التجاربية التجاربية التجاربية التجاربيةيعني إنه مش
+
+712
+01:11:36,970 --> 01:11:43,110
+تعطي إيش لمرضى له نسبة قليلة إنه بيموتوا لأ، هذا
+
+713
+01:11:43,110 --> 01:11:49,810
+بدك تثبت إنه الدواء أو التداخل أو طريقة العلاج أول
+
+714
+01:11:49,810 --> 01:11:55,990
+شيء مش قاتلة في هذه الناحية أو مش مضرة في هذه
+
+715
+01:11:55,990 --> 01:12:00,020
+المرحلة الأولى، ويكون عدد قليلإذا ثبت والله إله
+
+716
+01:12:00,020 --> 01:12:04,980
+شغل مافيش منه خطر مافيش منه ضرر بحط المرحلة ثاني
+
+717
+01:12:04,980 --> 01:12:13,000
+بزيد عدد الحالات وبصير أدور على يعني أقيم في أثر
+
+718
+01:12:13,000 --> 01:12:17,640
+في تحسين في الأثر اللي أنا بديها يعني كلكم الآن
+
+719
+01:12:17,640 --> 01:12:25,660
+بتابعوا السباق في العالم لـ مثلا الـ «Covid-19
+
+720
+01:12:25,660 --> 01:12:30,060
+Vaccine»فدائماً بيقولوا Stage 1 و Stage 2 و Stage
+
+721
+01:12:30,060 --> 01:12:39,300
+3 أو Phase 1 و Phase 2 و Phase 3 يعني قبل ما، لحد
+
+722
+01:12:39,300 --> 01:12:44,980
+ما نثبت أن الدواء فعال ومش مضر، يعني هذولا
+
+723
+01:12:44,980 --> 01:12:50,870
+الناحيتينوبكون بالأول، يعني حتى نثبت هذا الكلام من
+
+724
+01:12:50,870 --> 01:12:54,690
+خلال دراسات زي ما شُفته قبل شوية بتكون قضية أنه
+
+725
+01:12:54,690 --> 01:13:01,090
+أنا ممكن أعطي ناس placebo يعني بأعطيهم إشي ميّه
+
+726
+01:13:01,090 --> 01:13:06,550
+ملح يعني أو ما بأعطيهم إشي حقيقي يعني فهذه لأنها
+
+727
+01:13:06,550 --> 01:13:12,670
+تكون يعني دراسة بشكل سليم وبتكون زي ما بقولوا
+
+728
+01:13:12,670 --> 01:13:17,890
+blind، blind يعنيفيه الطبيب المعالج والمريض نفسه
+
+729
+01:13:17,890 --> 01:13:21,950
+ما بعرف هو انعطى الدواء الحقيقي اللي بدنا ندرسه
+
+730
+01:13:21,950 --> 01:13:28,150
+ولا نعطى placebo يعني مي وملح ومافيش فيه إشي لأن
+
+731
+01:13:28,150 --> 01:13:32,050
+العامل النفسي له تأثير كبير يعني أحيانًا في تحسن
+
+732
+01:13:32,050 --> 01:13:36,630
+المرضى 30% من متأثير الأدوية عادة بتكون placebo
+
+733
+01:13:36,630 --> 01:13:41,990
+يعني فالممكن
+
+734
+01:13:43,260 --> 01:13:49,920
+RNA interference يعني أني أعطيه RNA segment «أنا
+
+735
+01:13:49,920 --> 01:13:54,040
+ماعرفش هذه، ماعنديش خبرة فيها» induction of axons
+
+736
+01:13:54,040 --> 01:13:59,180
+skipping الـ «جين إدتينج» الـ «جين إدتينج» يعني
+
+737
+01:13:59,180 --> 01:14:06,240
+هذه الموضوع يعني إذا بدنا نتخيلها كطريقة علاج very
+
+738
+01:14:06,240 --> 01:14:14,290
+promising بس للآن حسب علمي مافيشما فيش يعني
+
+739
+01:14:14,290 --> 01:14:17,550
+تعديلها،
+
+740
+01:14:17,550 --> 01:14:25,990
+يعني استخدامها في نوع من العلاج
+
+741
+01:14:25,990 --> 01:14:32,090
+مرض معين كعلاج مقبول وكويس وكذا اللي هو موضوع
+
+742
+01:14:32,090 --> 01:14:41,710
+CRISPR9 هذا نوع من الأسليب المتطورة جداًفي المعالج
+
+743
+01:14:41,710 --> 01:14:46,230
+الوراثية «Gene Editing» يعني إن أنا بصير عندي
+
+744
+01:14:46,230 --> 01:14:53,770
+إنكالية أن أمسك أي قطعة الـ «DNA» بديّها وهي تم
+
+745
+01:14:53,770 --> 01:14:59,310
+اكتشافها من خلال البكتيريا وقلياتها في الدفاع عن
+
+746
+01:14:59,310 --> 01:15:05,730
+نفسها يعني نقل الخواص ودفاعها ضد الأمراض أو الغزو
+
+747
+01:15:05,730 --> 01:15:12,340
+من الفيروسات أو من إشي تانيفتستخدم البروتين أو
+
+748
+01:15:12,340 --> 01:15:18,820
+قلية الـ CRISPR9 الـ CRISPR9 يعني الـ Gene Editing
+
+749
+01:15:18,820 --> 01:15:23,420
+يعني أنا بجيب قطعة الـ DNA اللي بديها إذا كان
+
+750
+01:15:23,420 --> 01:15:29,720
+مثلاً في مكان مثلاً T ثايمين بحط أدينين، بحط
+
+751
+01:15:29,720 --> 01:15:34,680
+بجوانين، بحط اللي بديها ففي محل محدد أنا بشيل الـ
+
+752
+01:15:34,680 --> 01:15:39,780
+Nucleotide وبحط إشي تاني زي ما أنا بديفالآن
+
+753
+01:15:39,780 --> 01:15:42,840
+استخدام
+
+754
+01:15:42,840 --> 01:15:47,120
+هذه التقنية إذا بيقدروا بعدين يثبتوا إنها كويسة
+
+755
+01:15:47,120 --> 01:15:54,900
+لموضوع زي الـ «فلسيميا» زي الـ «التخلص الأساسي»
+
+756
+01:15:54,900 --> 01:16:00,480
+لما سهلة وده بتعرفها وعرفت شو المطلوب وشو الخلل
+
+757
+01:16:00,480 --> 01:16:05,460
+اللي موجود وعرفت الطفرة بالذات شو هي بيكون مقبول
+
+758
+01:16:05,460 --> 01:16:06,940
+وكويس أخلاقياً
+
+759
+01:16:10,740 --> 01:16:16,020
+بالنسبة لـ CRISPR الواحدين اللي استخدموه حقيقة
+
+760
+01:16:16,020 --> 01:16:24,760
+بشكل لا أخلاقي هما في الصين واحد بن قوسين يعتبرونه
+
+761
+01:16:24,760 --> 01:16:33,040
+مختل وحجروا عليه وحبسوه بعدين وكذا طبيب حاول يعمل
+
+762
+01:16:33,040 --> 01:16:42,340
+CCR5 جينالـ activation في الأجنة
+
+763
+01:16:42,340 --> 01:16:51,040
+تبعت عائلة HIV positive يعني الفكرة هنا أن أبوه
+
+764
+01:16:51,040 --> 01:17:02,280
+ثري جداً صيني أظن ويلدله الـ CRISPR في الجنين يعني
+
+765
+01:17:02,280 --> 01:17:10,220
+في الـfertilized egg للآنفيه يعني .. يعني هنا
+
+766
+01:17:10,220 --> 01:17:14,580
+بتعطينا مجال إنه نلعب بالماد الوراثية تبع الإنسان
+
+767
+01:17:14,580 --> 01:17:23,040
+أو تبع الكائن الحي فلما نكون .. يعني وفاق من
+
+768
+01:17:23,040 --> 01:17:29,500
+المشاكل الأخلاقية الوراثة بتدخلنا فيها إنه .. إنه
+
+769
+01:17:29,500 --> 01:17:35,030
+..إذا عندي مرض معروف وبدأ أستخدم هذه التقنية عشان
+
+770
+01:17:35,030 --> 01:17:40,610
+أعالج المرض، هذا مقبول وإذا بتقدر تثبت إنه كويس،
+
+771
+01:17:40,610 --> 01:17:46,190
+تمام بس هذا الإنسان والتجربة الصينية هذه كانت في
+
+772
+01:17:46,190 --> 01:17:54,010
+إنهم يحاولوا حسب الـMutationفي الـ CCR5 اللي
+
+773
+01:17:54,010 --> 01:17:58,150
+اتكلمنا عنها مرة في نسبة للـ Variation للـ
+
+774
+01:17:58,150 --> 01:18:03,210
+Susceptibility للـ HIV يعني في ناس لاحقوا إنه حتى
+
+775
+01:18:03,210 --> 01:18:06,930
+لو اتعرض للـ HIV ما بنصاب ما بيقدر الـ Virus يدخل
+
+776
+01:18:06,930 --> 01:18:13,260
+جوا الخلايا السبب إنه عنده شكل الـ CCR5 مختلففهذا
+
+777
+01:18:13,260 --> 01:18:18,200
+الصيني بدّه بناته ما يتعرضوا لأن هو ومرته كانوا
+
+778
+01:18:18,200 --> 01:18:21,840
+عندهم انشابي نفسهم بيأخذ أدوية وبيعالج حاله بس
+
+779
+01:18:21,840 --> 01:18:27,180
+بدّه زيادة في التأكد بدّه الأجنة تبعته الأولاد
+
+780
+01:18:27,180 --> 01:18:34,400
+وبناته يطلعوا ما عندهم أو عندهم الجين المقاوم بهذه
+
+781
+01:18:34,400 --> 01:18:45,740
+الطريقة فاشتغلوا CRISPR علىعلى الأجنة وهذا أخلاقيا
+
+782
+01:18:45,740 --> 01:18:54,840
+غير مقبول السبب أن هذا شيء دينيا وعلميا وأخلاقيا
+
+783
+01:18:54,840 --> 01:19:00,930
+للآن محرم ومجرم وعشان ذلك يعنيفي حتى محاولة تمنع
+
+784
+01:19:00,930 --> 01:19:06,670
+عملية إجراء الدراسات على الأجنة والأجنة جزء منها
+
+785
+01:19:06,670 --> 01:19:12,690
+بيطلع زيادة على بعد عمليات التلقيح خارج الجسم In
+
+786
+01:19:12,690 --> 01:19:17,090
+-vitro fertilization فأحيانًا بيظل الأجنة زايدة
+
+787
+01:19:17,090 --> 01:19:21,010
+فاللي بيحاول أنه يشتغل على هذه الأشياء بتكون مش
+
+788
+01:19:21,010 --> 01:19:26,550
+مظبوطة فللآن الـGene Editing promising يعني واعد
+
+789
+01:19:26,550 --> 01:19:35,630
+ممكن يستخدمولكن يعني فيه مشاكل أخلاقية ممكن الواحد
+
+790
+01:19:35,630 --> 01:19:41,570
+يعني يعمل «بوميرو ترانسفلانتيشن» «Core Blood Stem
+
+791
+01:19:41,570 --> 01:19:47,750
+Cell Transplantation» «Liver Transplantation» برضه
+
+792
+01:19:47,750 --> 01:19:55,290
+ممكن يعني بالذات فقيت الـ «Liver» في قضيةإن
+
+793
+01:19:55,290 --> 01:20:00,210
+أحيانًا كثيرة الـenzymes للـ«ميتابوليزم» بتكون في
+
+794
+01:20:00,210 --> 01:20:05,070
+الـLiver فلما واحد ينقل liver كويس لإنسان ثاني
+
+795
+01:20:05,070 --> 01:20:13,490
+ممكن يعوض المشاكل يعني آي
+
+796
+01:20:13,490 --> 01:20:19,770
+برضه دراسات أشياء ثانية الفكرة
+
+797
+01:20:19,770 --> 01:20:25,290
+في الـPomeroإنه يعني
+
+798
+01:20:25,290 --> 01:20:29,810
+الحسانف أو الميزة في الـ Bomber أو الـ Stem Cell
+
+799
+01:20:29,810 --> 01:20:37,490
+بقول إنه ميكانيكيا وأدائها يعني نقل الكبد يعني
+
+800
+01:20:37,490 --> 01:20:44,970
+عملية خطرة وطويلة ومعقدة ويعني إلها مشاكلها
+
+801
+01:20:44,970 --> 01:20:51,490
+الكبيرة وكذا إن الواحد ينقل الكبد منسواء المتبرع
+
+802
+01:20:51,490 --> 01:20:58,210
+حي زي قريب للمريض أو من cadaver يعني إنسان ميت
+
+803
+01:20:58,210 --> 01:21:05,850
+دماغياً وكدا دايماً فيها أشكالات كبيرة فأظن هيك
+
+804
+01:21:05,850 --> 01:21:09,830
+Somatic
+
+805
+01:21:09,830 --> 01:21:13,690
+tissue الـ
+
+806
+01:21:13,690 --> 01:21:18,880
+Gene Therapyيعني هنا الـ Somatic Tissue بنحاول أنه
+
+807
+01:21:18,880 --> 01:21:23,360
+نحط يعني
+
+808
+01:21:23,360 --> 01:21:29,620
+الفكرة هنا زي المثال اللي حكيته أنا عن الـ CRISPR
+
+809
+01:21:29,620 --> 01:21:36,960
+هو عبارة عن أخده الأجنة الخلية الملقحة الأولى وعدل
+
+810
+01:21:36,960 --> 01:21:42,270
+فيها فالنتيجة بتصير أنهالتغيير والتعديل اللي أنا
+
+811
+01:21:42,270 --> 01:21:46,450
+سويته موجود في كل الخلايا أما لو أخدت جزء من
+
+812
+01:21:46,450 --> 01:21:51,790
+الخلايا في جسم الإنسان كامل وعدلت فيها إشي ورجعتله
+
+813
+01:21:51,790 --> 01:21:56,670
+إياها هذه بتكون يعني بدنا نسميها Somatic Tissue
+
+814
+01:21:56,670 --> 01:22:03,970
+Modification يعني مثلا أخدت من إنسان قطعة كبد
+
+815
+01:22:03,970 --> 01:22:09,130
+وبعدين بالطريقة اللي ماوأنا حاطي إن الـ Retroviral
+
+816
+01:22:09,130 --> 01:22:14,410
+Vector أو بسلوب معين دخلت إشي تاني أهم جانب في
+
+817
+01:22:14,410 --> 01:22:18,510
+إدخال جينات جديدة عن طريق الـ Bomber هو أسهل واحد
+
+818
+01:22:18,510 --> 01:22:23,630
+وأكثر واحد يعني يستخدم في أشياء كثيرة يعني أظن هيك
+
+819
+01:22:23,630 --> 01:22:35,750
+خلصنا أمثلة يعني إن شاء الله تكون يعني هي فصل فيه
+
+820
+01:22:35,750 --> 01:22:49,170
+أشياء كثيرةمتقدم كثير، يعني أحيانًا لسه مش مثبت
+
+821
+01:22:49,170 --> 01:22:58,470
+كثير هات الواحد يكون متأكد منها وبدها طب قوي جدًا،
+
+822
+01:22:58,470 --> 01:23:05,370
+يعني متقدم، فيه عنده خبرة وفهم طبعًا الأمراض
+
+823
+01:23:05,370 --> 01:23:10,020
+الوراثية اللي بهذا الشكلفي الغالب، يعني غير
+
+824
+01:23:10,020 --> 01:23:13,600
+الثلاثيمي أو الـ Sickle Cell لأنها قريبة كثيرًا في
+
+825
+01:23:13,600 --> 01:23:20,160
+كثير أشياء يعني بحيث أنها تكون نادرة وجزء من نجاعة
+
+826
+01:23:20,160 --> 01:23:31,160
+وتحسن الدواء المعين هو في أنه يتم
+
+827
+01:23:31,160 --> 01:23:39,700
+تجربته من خلال تجارب علميا سليمة وكويسةفإذا في حد
+
+828
+01:23:39,700 --> 01:23:50,680
+عنده أسئلة أهلا وسهلا فيكم أو بنختم هكذا في سؤال
+
+829
+01:23:50,680 --> 01:23:57,660
+يا دكتور من كريم بخصوص الأمراض والتدخلات التي تم
+
+830
+01:23:57,660 --> 01:24:05,380
+ذكرها كلها تقول أن عددها كبير وتشعوباتها كثيرةأيش
+
+831
+01:24:05,380 --> 01:24:11,040
+اللي مطلوب نركز عليه منها أو أيش المفترض نحفظه
+
+832
+01:24:11,040 --> 01:24:19,040
+منها بمعنى هذا؟ لأ، انت شوف، أنا بقترح نركز على
+
+833
+01:24:19,040 --> 01:24:24,360
+اللي أنا اتكلمت عنه في المحاضرات يعني الـDenisol
+
+834
+01:24:24,360 --> 01:24:30,650
+Hereditary Angioneurotic Edemaوالله موجود وبستخدمه
+
+835
+01:24:30,650 --> 01:24:37,270
+وعندي مثلا اللي عندهم Hemophilia وبعطيه Protein
+
+836
+01:24:37,270 --> 01:24:43,310
+هذا واضح ومستخدم جداً ومرضى الـ Hemophilia أيهم
+
+837
+01:24:43,310 --> 01:24:48,090
+بيجوا على الطوارئ ويكون عندهم نزف في العضلات، في
+
+838
+01:24:48,090 --> 01:24:52,150
+المفاصل، في الـ «كدا» اللي هو مرض الناعور اللي هو
+
+839
+01:24:52,150 --> 01:24:57,570
+Hemophilia اللي هو شدة النزف، شايف عليا؟فهي
+
+840
+01:24:57,570 --> 01:25:04,170
+الأشياء اللي أنا بظن … يعني أركز الواحد اللي فيها
+
+841
+01:25:04,170 --> 01:25:09,710
+جداول في قضية المبادئ وانا حرست إنه في المحاضرة
+
+842
+01:25:09,710 --> 01:25:16,430
+أشرح المبدأ وأعطيكم بعض المعلومات السريرية فهي
+
+843
+01:25:16,430 --> 01:25:22,020
+اللي أنا بتوقع اللي أتحكيت عنهاهي اللي ركزوا عليها
+
+844
+01:25:22,020 --> 01:25:27,880
+وده بس المحاضرة يعني بالنسبة
+
+845
+01:25:27,880 --> 01:25:35,560
+للمن يحكوا معلومة ويحطوها إنه لسه ضمن تجارب معينة
+
+846
+01:25:35,560 --> 01:25:42,380
+هذا دليل على إنها لسه مش إشي ثابت ومعتمد بس بيظل
+
+847
+01:25:42,380 --> 01:25:48,560
+إنه ممكن يعني إنه ممكن في المستقبل يعني الدنيا
+
+848
+01:25:48,560 --> 01:25:55,590
+تتطور قبلقبل 40 سنة أو 30 سنة لما أنا كنت طالب كنا
+
+849
+01:25:55,590 --> 01:25:58,970
+كلنا طبنا على المراجع والكتب و«ديفيدسون»
+
+850
+01:25:58,970 --> 01:26:03,430
+و«هاريسون» وتروح المكتب وتروح الدو وتمسك الكتاب
+
+851
+01:26:03,430 --> 01:26:08,510
+وتقعد كذا لأن الدنيا اتغيرت كلنا على الـ «جوجل»
+
+852
+01:26:08,510 --> 01:26:14,650
+وعلى الكمبيوتر و«أب تو ديت» و«باب ميد» والأشياء
+
+853
+01:26:14,650 --> 01:26:22,080
+هذه آليات الدنيا أحيانًا بتختلففأنا بظن يعني
+
+854
+01:26:22,080 --> 01:26:28,100
+الواحد يأخذها هدف الواحد منها أنه يطلع دكتور كويس
+
+855
+01:26:28,100 --> 01:26:31,840
+الدكتور الكويس بدي يكون مجهز حاله للمستقبل
+
+856
+01:26:31,840 --> 01:26:38,000
+المستقبل نحكي فيه أنه يعني يمكن اليوم والآن وفي
+
+857
+01:26:38,000 --> 01:26:44,060
+هذه اللحظة يعني أنا ما بدعي أنه حتى الأردن ولا حتى
+
+858
+01:26:44,060 --> 01:26:49,810
+جيرانكم ولا في فلسطين وغزةحتى عند اليهود يعني
+
+859
+01:26:49,810 --> 01:26:53,410
+مثلًا يهود بشكل عام متقدمين يعني بالذات في الأمراض
+
+860
+01:26:53,410 --> 01:26:59,170
+الوراثية يعني بتلاقيهم حارسين عليها الآن المبدأ
+
+861
+01:26:59,170 --> 01:27:06,590
+أنه أنا أفهم المبدأ يعني أن هذا ممكن أنا إذا بشك
+
+862
+01:27:06,590 --> 01:27:13,710
+أنه الحالة وراثية وفي تاريخ عائلي وكذا حتى لو
+
+863
+01:27:17,190 --> 01:27:22,330
+حتى لو ما فيش في الدنيا زي الحال من قبل المفروض إن
+
+864
+01:27:22,330 --> 01:27:28,230
+الواحد يسعى إنه يفهم الـ Pathogenesis عشان يفكر في
+
+865
+01:27:28,230 --> 01:27:34,550
+دوة بأسلوب معين فالتفكير هذا يعني أنا والله اللي
+
+866
+01:27:34,550 --> 01:27:38,390
+هو سرطان هذا في الـ Marfan أول مرة بدري عنه يعني
+
+867
+01:27:38,390 --> 01:27:41,650
+أنا ماكنتش منتبه إلو يعني أو على الأقل ماعنديش
+
+868
+01:27:41,650 --> 01:27:46,670
+الاختصاص الكبير هذا فيهفإن الواحد يكون منتبه إنه
+
+869
+01:27:46,670 --> 01:27:51,850
+له سرطان وقراءة Carbo شائع جداً ودواء يعني نسبياً
+
+870
+01:27:51,850 --> 01:28:00,730
+بسيط يعني .. يعني available ومش غالي ويعني من
+
+871
+01:28:00,730 --> 01:28:06,950
+أنواع الأدوية الضغط الأغلى شوية بس يعني مش very
+
+872
+01:28:06,950 --> 01:28:10,530
+very expensive وvery available فوالله الواحد هذا
+
+873
+01:28:10,530 --> 01:28:15,710
+بيفيد مرض زي هيكأنا باعتبر أن هذه معلومة مهمة يعني
+
+874
+01:28:15,710 --> 01:28:22,210
+أنا بالنسبة إليه يعني ماشي فالآن يا كريم أنتوا في
+
+875
+01:28:22,210 --> 01:28:28,690
+صباق أنتوا كمجموعة طلاب طب في الجامعة في صباق بدك
+
+876
+01:28:28,690 --> 01:28:35,970
+تكون الأول بدك تكون أحسن بتعرف أكتر وانت وحر ماشي
+
+877
+01:28:35,970 --> 01:28:42,910
+غيره؟ في أسئلة في نفس المواضيع يعني؟في نفس
+
+878
+01:28:42,910 --> 01:28:48,930
+الأدوية؟ غالباً لأ يا دكتور طيب يالله يعطيكم
+
+879
+01:28:48,930 --> 01:28:53,290
+العافية ونشوفكم الأسبوع القادم إن شاء الله سؤال
+
+880
+01:28:53,290 --> 01:28:57,750
+آخر دكتور أحمد بالنسبة للامتحان
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/u_JvIjOn4A0.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/u_JvIjOn4A0.srt
new file mode 100644
index 0000000000000000000000000000000000000000..92976929ff96e1d8992410671d418002827f0838
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/u_JvIjOn4A0.srt
@@ -0,0 +1,2325 @@
+1
+00:00:02,080 --> 00:00:09,880
+الـShare أمورنا
+
+2
+00:00:09,880 --> 00:00:19,600
+كويسة في شباب وداخلين أربعة لسة طيب نبدأ
+
+3
+00:00:19,600 --> 00:00:24,320
+زي كل مرة في الأول في أسئلة على الأشياء اللي تم
+
+4
+00:00:24,320 --> 00:00:28,240
+نقاشها من قبل، في حد عنده سؤال في الورقة؟
+
+5
+00:00:33,750 --> 00:00:42,310
+إذا في حد عنده سؤال يعني يتكلم بس إحنا يعني
+
+6
+00:00:42,310 --> 00:00:46,450
+بالنسبة لمحاضرة اليوم اللي كان المفروض الأسبوع
+
+7
+00:00:46,450 --> 00:00:51,470
+اللي فات وكان فيها مشكلة بالنسبة لأن انقطعت الكهربا
+
+8
+00:00:51,470 --> 00:00:59,950
+واتخرّبت الأمور، إحنا ندخل الآن في أمثلة متعددة عن
+
+9
+00:00:59,950 --> 00:01:11,770
+أنواع من الأمراض الوراثية ونحاول نعمل شرح عن يعني
+
+10
+00:01:11,770 --> 00:01:20,570
+مسبباتها وأنواع الطفرات، أنواع الآليات الـ
+
+11
+00:01:20,570 --> 00:01:29,910
+Mechanisms لتسبب بهذه الأمراض الوراثية، صراحة يعني
+
+12
+00:01:29,910 --> 00:01:36,500
+الـ قائمة طويلة، القائمة طويلة من الأمراض اللي
+
+13
+00:01:36,500 --> 00:01:44,680
+حاطينها في الكتاب وأنا يعني اللي بدي إياه من ناحية
+
+14
+00:01:44,680 --> 00:01:53,540
+ثانية، من ناحية أولى اللي هي إن الواحد يعني لما
+
+15
+00:01:53,540 --> 00:01:59,480
+تقول له يتطلع على القائمة هذه وعلى الأقل هي نسبياً
+
+16
+00:01:59,480 --> 00:02:04,650
+بالنسبة لعدد الأمراض الوراثية المعروفة هي لسة قصيرة
+
+17
+00:02:04,650 --> 00:02:14,750
+جداً وإشي يعني قليل كثير، ولكن الأمراض في الـ في
+
+18
+00:02:14,750 --> 00:02:22,930
+الحياة وعند أي population إذا حنـنشوف بتلاقوا أمراض
+
+19
+00:02:22,930 --> 00:02:31,860
+متنوعة وكثير كثير، فبدي أن الواحد يكون عنده يعني
+
+20
+00:02:31,860 --> 00:02:37,380
+قدرة على إنه لما يعرف إنه فيه مرض فلاني كيف يرجع
+
+21
+00:02:37,380 --> 00:02:42,660
+لِمرجع، يعني الآن أنا بستخدم كثير الـInternet
+
+22
+00:02:42,660 --> 00:02:48,500
+وGoogle على أساس الـOnline Source
+
+23
+00:02:48,500 --> 00:02:55,620
+للـGenetic Mendelian Diseases وبشوف، بقرا عن شو
+
+24
+00:02:55,620 --> 00:03:00,740
+كاتبين عن الموضوع هذا، ف يعني الواحد يربي نفسه أو
+
+25
+00:03:00,740 --> 00:03:07,380
+يُعلّم حاله على إنه يقدر يرجع لمرجع معين يقرأ عن أي
+
+26
+00:03:07,380 --> 00:03:12,820
+مرض وكذا، والمطلوب الثاني إنه يقدر الواحد إيش هي
+
+27
+00:03:12,820 --> 00:03:17,420
+الـGenetic Mechanism، أتكلمنا على أنواع مشاكل
+
+28
+00:03:17,420 --> 00:03:27,780
+كثيرة، فنتكلم عنهم، يعني قصدي على أنواع المشاكل اللي
+
+29
+00:03:27,780 --> 00:03:36,020
+بتعمل مشاكل في الوراثة وبتكون أمراض وراثية فيها
+
+30
+00:03:36,020 --> 00:03:43,700
+كأنه مؤتزر رافع إيده أو إشي؟
+
+31
+00:03:43,700 --> 00:03:51,440
+لأ تمام الأمور، بالتأكيد طيب بالنسبة لكتابكم
+
+32
+00:03:52,520 --> 00:03:56,960
+حاطط الـ… الـ… طبعاً إحنا أخذنا بالمحاضرة اللي
+
+33
+00:03:56,960 --> 00:04:01,040
+فاتت السابقة الـHemoglobinopathies واتكلمنا على
+
+34
+00:04:01,040 --> 00:04:06,560
+أنواعهم وسمينا الـSicklers والـThalassemias والأنواع
+
+35
+00:04:06,560 --> 00:04:12,540
+الثانية وأخذناهم كشيء يعني متخصص، درسنا أنواع
+
+36
+00:04:12,540 --> 00:04:19,940
+الـGenetic Mutations اللي بتعملها، كترتيب
+
+37
+00:04:19,940 --> 00:04:25,220
+للمجموعة الأمراض اللي حاططها وأنا بقدر هنا يعني
+
+38
+00:04:25,220 --> 00:04:30,100
+حاطط لكم تقريباً دي أربعة، ستة، اثنين، أربعة، عشرة
+
+39
+00:04:30,100 --> 00:04:35,400
+يعني حاطط خمسة وعشرين، ثلاثين مرض تقريباً، طالب
+
+40
+00:04:35,400 --> 00:04:41,160
+إنكم على الأقل يكون الواحد منكم عارف إيش هي وإيش
+
+41
+00:04:41,160 --> 00:04:45,300
+نوعية المشكلة اللي موجودة فيها وكيف الـ
+
+42
+00:04:48,260 --> 00:04:55,120
+فهنا الآن الطفرات أو الأمراض الوراثية أو الآليات
+
+43
+00:04:55,120 --> 00:05:01,440
+اللي تسببت في المرض هذا، فطريقة تقسيم الكتاب
+
+44
+00:05:01,440 --> 00:05:08,820
+بالنسبة لهذا الموضوع إنه حاكاهم على شكل يعني
+
+45
+00:05:08,820 --> 00:05:17,720
+مجموعات ضمن تركيب الخلية، ففي مجموعة أمراض بتكون
+
+46
+00:05:17,720 --> 00:05:22,240
+فيها مشاكل في الـ organelles، العضيات اللي جوا
+
+47
+00:05:22,240 --> 00:05:26,760
+الخَلْيَة، أو أولهم الـ mitochondria، فحاطين Leber
+
+48
+00:05:26,760 --> 00:05:32,340
+hereditary optic neuropathy وفي LD1 protein
+
+49
+00:05:32,340 --> 00:05:39,320
+أو electron transport chain defects، فحاطط أمثلة
+
+50
+00:05:39,320 --> 00:05:44,140
+Translation of the mitochondrial
+
+51
+00:05:44,140 --> 00:05:52,050
+proteins زي الـMyoclonus، إحنا راح ناخد واحد منهم ونشوف
+
+52
+00:05:52,050 --> 00:05:57,730
+يعني هيكون هو شارح، يفترض إنه الواحد منكم لما نقرأ
+
+53
+00:05:57,730 --> 00:06:00,870
+صحيح يعني، يمكن المرض الواحد ما شافش ولا حالة منه
+
+54
+00:06:01,330 --> 00:06:07,790
+بكون هذا يعني مزعج
+
+55
+00:06:07,790 --> 00:06:15,310
+أو يعني حالة، يعني بسبب ضعف اللي الواحد يفهم شو هو
+
+56
+00:06:15,310 --> 00:06:21,380
+المرض، يعني مش زي لما نكون شفنا حالة، وفي الـ
+
+57
+00:06:21,380 --> 00:06:26,740
+Peroxisomes زي الـZellweger Syndrome اللي هي فيه
+
+58
+00:06:26,740 --> 00:06:32,240
+12 بروتين، أو الـLysosomes زي الـTay-Sachs Disease أو
+
+59
+00:06:32,240 --> 00:06:35,920
+الـHurler's Syndrome، في الـExtracellular
+
+60
+00:06:35,920 --> 00:06:41,080
+Proteins، الـTransport زي حكينا الـGlobulin في
+
+61
+00:06:41,080 --> 00:06:43,600
+الـHemoglobin زي الـSickle cell anemia أو
+
+62
+00:06:43,600 --> 00:06:47,960
+الثلاسيميا، الـMorphogens اللي هي زي
+
+63
+00:06:53,290 --> 00:07:00,950
+encephalopathy، التهاب الدماغ، انتفاخ، أو Alpha
+
+64
+00:07:00,950 --> 00:07:04,510
+1-antitrypsin deficiency، زي البروتياز إنْهِبِتُر
+
+65
+00:07:05,100 --> 00:07:11,740
+Hemostasis زي الـHemophilia A وB، الـHormones زي
+
+66
+00:07:11,740 --> 00:07:14,960
+الإنسولين، في الـRare Forms بتاعتها، في
+
+67
+00:07:14,960 --> 00:07:20,520
+الـCollagen زي الـCollagen Type I Disease
+
+68
+00:07:20,520 --> 00:07:26,340
+Osteogenesis Imperfecta، الـComplement زي
+
+69
+00:07:26,340 --> 00:07:31,080
+الـHereditary Angioneurotic oedema، Complement
+
+70
+00:07:31,080 --> 00:07:35,480
+Age-related macular
+
+71
+00:07:35,480 --> 00:07:40,980
+degeneration، الـMetabolic enzymes زي الـPKU فنعني
+
+72
+00:07:40,980 --> 00:07:47,240
+الـPhenylketonuria اللي هو الفينيل كيتون يوريا، الـdisease
+
+73
+00:07:47,240 --> 00:07:51,120
+أو الـAdenosine Deaminase اللي هو السبب للـSCID
+
+74
+00:07:51,120 --> 00:07:54,820
+Severe Combined Immune Deficiency، أو Duchenne
+
+75
+00:07:54,820 --> 00:08:01,340
+Muscular Dystrophy، بسبب مشكلة الديستروفين، أو بالـ
+
+76
+00:08:01,340 --> 00:08:07,300
+Nucleus itself زي الـAniridia اللي هي أنه ما فيش
+
+77
+00:08:07,300 --> 00:08:14,200
+Iris، فيه مشكلة،  BRCA1,2 اللي هم مرتبطين بالكانسر
+
+78
+00:08:14,200 --> 00:08:21,410
+Hereditary Non-polyposis Colon Cancer، DNA mismatch،
+
+79
+00:08:21,410 --> 00:08:25,890
+repair proteins، Fragile X syndrome،
+
+80
+00:08:25,890 --> 00:08:34,430
+Retinoblastoma، مشكلة السرطان ومشكلة الشبكية،
+
+81
+00:08:34,430 --> 00:08:42,750
+الـCML، الفرديل فيه كروموزوم، الـcell surface زي
+
+82
+00:08:42,750 --> 00:08:48,170
+الـAndrogen insensitivity أو الـAchondroplasia
+
+83
+00:08:50,380 --> 00:08:54,460
+أو الـHypercholesterolemia أو الـCystic Fibrosis
+
+84
+00:08:54,460 --> 00:08:57,560
+أو الـType 1 Diabetes، يعني هذه الأمثلة اللي بدنا
+
+85
+00:08:57,560 --> 00:09:03,300
+ناخذها إذا
+
+86
+00:09:03,300 --> 00:09:09,300
+بدنا نحاول نشوف، أو إذا كان هو شارح كثير، بس بدي
+
+87
+00:09:09,300 --> 00:09:15,160
+يكون الواحد لما يقرأ تفاصيل المرض، بدي نحاول إن
+
+88
+00:09:15,160 --> 00:09:21,520
+إحنا نوصل اليوم فيه إنه كيف الاختلال الجيني أدى
+
+89
+00:09:21,520 --> 00:09:25,900
+للمظهر اللي عندنا، وشوفي الاختلالات اللي كانت في
+
+90
+00:09:25,900 --> 00:09:33,720
+الجينات من أي ناحية وكيف نتجت عنها الأمراض
+
+91
+00:09:33,720 --> 00:09:41,200
+هذه، بدنا نتذكر أنه يعني الآن صحيح الجين في الغالب
+
+92
+00:09:41,200 --> 00:09:45,000
+مش قطعة واحدة، في Exons and Introns بحيث أنه إحنا
+
+93
+00:09:45,000 --> 00:09:52,620
+بحاجة إنه، أدت قطع بالأخير تمت إلى قضية الـ
+
+94
+00:09:52,620 --> 00:09:58,600
+Transcription لتنطلق الـRNA، فحتى تعرف آلية الخلية
+
+95
+00:09:58,600 --> 00:10:04,840
+من أين تبدأ أو أين تتوقف لازم فيه Control لازم فيه
+
+96
+00:10:04,840 --> 00:10:10,000
+آليات تحكم، ففي منطقة الـPromoter Region الـ
+
+97
+00:10:10,000 --> 00:10:18,360
+Start Codon، فيه آليات وفيه أشياء حتى تنشط هذا
+
+98
+00:10:18,360 --> 00:10:23,860
+الـGene وتبقى تعرف من وين تبدأ ولوين تتوقف، فهذه
+
+99
+00:10:23,860 --> 00:10:29,120
+آلية قد تُصيب نفس الـGene قد تحدث له مشكلة بعد
+
+100
+00:10:29,120 --> 00:10:33,720
+هيك لما يطلع الـMessenger RNA، بدي يُعمَل عليه شغل
+
+101
+00:10:33,720 --> 00:10:39,690
+أحياناً الشغل هذا هو اللي بيكون فيه مشكلة، الحالة
+
+102
+00:10:39,690 --> 00:10:48,910
+الأولى اللي بتكلموا عنها إشي اسمه الـPhenylketonuria
+
+103
+00:10:48,910 --> 00:10:58,130
+(PKU)، الـPKU مرض يعني تقريباً يعني
+
+104
+00:10:58,130 --> 00:11:03,510
+إحنا بالأردن ما بين 300 لـ 800 مصاب فيه، يعني
+
+105
+00:11:03,510 --> 00:11:08,630
+تقريباً واحد بالألف وواحد بالثلاثمئة وواحد
+
+106
+00:11:08,630 --> 00:11:17,690
+بالخمس مئة، فيه تفاوت في الـ فيه تفاوت في النسب
+
+107
+00:11:17,690 --> 00:11:22,870
+وخصوصاً إنه بالذات مع الـConsanguinity، زواج
+
+108
+00:11:22,870 --> 00:11:27,770
+الأقارب، يكون نسبة الحدوث أكبر بكثير، إشارة عن
+
+109
+00:11:27,770 --> 00:11:30,050
+بالأخير، مجموعة
+
+110
+00:11:33,810 --> 00:11:38,770
+«biochemical pathways»، «anomalies» التي ستؤدي إلى
+
+111
+00:11:38,770 --> 00:11:44,230
+الـHyperphenylalaninemia، الفينيل ألانين أحد الـAmino
+
+112
+00:11:44,230 --> 00:11:53,150
+Acids، إذا بيزيد كثير بعمل مشكلة بالدرجة بالنسبة للـ
+
+113
+00:11:53,150 --> 00:11:57,590
+nervous system development، يعني بيصير أنه ليس
+
+114
+00:11:57,590 --> 00:12:02,810
+الجهاز العصبي في خلل، في الـClassical ones، شعرهم
+
+115
+00:12:02,810 --> 00:12:07,610
+بيكون على لون أحمر شوية، هو في لونه شوية مختلف، مميز
+
+116
+00:12:07,610 --> 00:12:14,590
+نوعاً ما، بس يمكن يولدوا في الغالب نتيجة أن الفينيل
+
+117
+00:12:14,590 --> 00:12:20,450
+ألانين في خلال فترة الحمل، يعني بتتمّ التحكم فيه
+
+118
+00:12:20,450 --> 00:12:28,630
+كمان عن طريق الأم، هي إنه ممكن لو ارتفع يتمّ تنزيله
+
+119
+00:12:28,630 --> 00:12:35,330
+عن طريق الـMetabolism تبع الأم، بعد
+
+120
+00:12:35,330 --> 00:12:40,270
+الولادة، بتظل مرتفع وبتصير فيه مشكلة، الـ
+
+121
+00:12:40,270 --> 00:12:47,090
+phenylalanine is metabolized by a hydroxylase, it
+
+122
+00:12:47,090 --> 00:12:52,610
+will change it from phenylalanine to tyrosine، فهذه
+
+123
+00:12:52,610 --> 00:12:57,830
+النقطة الأساسية، فالـPhenylalanine Hydroxylase هو
+
+124
+00:12:57,830 --> 00:13:03,870
+الإنزيم، على أقل تقدير في الـClassical PKU، الحلّ
+
+125
+00:13:03,870 --> 00:13:09,990
+أو الملاحظة على الـPKU اللي هو قضية إنه الـ
+
+126
+00:13:09,990 --> 00:13:17,270
+Treatment تبعته، وعشان نحافظ على الـMental
+
+127
+00:13:17,270 --> 00:13:21,770
+Capacity، يعني it is a major cause of preventable
+
+128
+00:13:21,770 --> 00:13:29,130
+mental retardation، يعني التخلف العقلي ونمو الدماغ
+
+129
+00:13:29,130 --> 00:13:36,810
+في الإنسان، إذا تم التنبه لهذه الحالة وعلاجها أو
+
+130
+00:13:36,810 --> 00:13:41,010
+التعامل معاها بالطريقة السليمة اللي هي عن طريق الـ
+
+131
+00:13:41,010 --> 00:13:44,330
+Low Phenylalanine Diet، يعني اللي هو Low Protein
+
+132
+00:13:44,330 --> 00:13:50,160
+Diet، الفينيل ألانين موجود في مجموعة بروتينات
+
+133
+00:13:50,160 --> 00:13:57,220
+وبالتالي لما نكون نعطي نصائح وفيه يعني Literature
+
+134
+00:13:57,220 --> 00:14:06,440
+واضح شو هي الأكلات اللي فيها يعني الخبز،
+
+135
+00:14:06,440 --> 00:14:10,480
+الذرة،
+
+136
+00:14:10,480 --> 00:14:12,780
+البقوليات،
+
+137
+00:14:14,800 --> 00:14:18,060
+الأجبان، يعني كلها بتصير ممنوعة لأن فيها نسبة
+
+138
+00:14:18,060 --> 00:14:25,760
+عالية من البروتينات، وبالتالي الأهل يعني هي مشكلة ليش
+
+139
+00:14:25,760 --> 00:14:32,140
+أقول يعني دائمة، بس مشكلة طويلة بالنسبة للعائلة
+
+140
+00:14:32,140 --> 00:14:36,700
+اللي بيكون عندها مصابين، من ناحية إنه بدهم يتفهموا
+
+141
+00:14:36,700 --> 00:14:44,420
+لأكلِهم، وقضية إن الواحد ياكل أكل يعني مُخصّص، مش قضية
+
+142
+00:14:44,420 --> 00:14:54,140
+سهلة، يعني بحاجة لـ بحاجة لـ علم، وبحاجة لتنظيم، وبـ
+
+143
+00:14:54,140 --> 00:14:59,960
+بحاجة لإرادة، وبحاجة لدعم من المجتمع على قضية يعني
+
+144
+00:14:59,960 --> 00:15:05,440
+إحنا في الأردن جمعية الـPKU، جمعية الـPhenylketonuria
+
+145
+00:15:05,440 --> 00:15:13,440
+الأردنية، أنا عضو فيها، ويعني بنوفر الأكلات اللي هي
+
+146
+00:15:13,440 --> 00:15:21,720
+قليلة البروتين، قليلة البروتين، بعضها يعني ممكن نفس
+
+147
+00:15:21,720 --> 00:15:29,160
+الإنسان يتعامل معها، يعني كل الـ كل
+
+148
+00:15:29,160 --> 00:15:31,580
+الورقيات
+
+149
+00:15:32,220 --> 00:15:37,840
+يعني ملّوخية، بقدونس، أشياء زي ذلك، فيه أشياء
+
+150
+00:15:37,840 --> 00:15:43,660
+مسموحة، وهذه ممكن الإنسان يأكلها وما بتأثرش فالـ
+
+151
+00:15:43,660 --> 00:15:49,360
+بالنسبة للطفرات
+
+152
+00:15:49,360 --> 00:15:58,860
+المتوقعة، ثبت بعدين إنه عبارة عن أكثر من نوع، وفي
+
+153
+00:15:58,860 --> 00:16:05,290
+عندنا الـClassical PKU، وفي الـVariant PKU، وفي الـ
+
+154
+00:16:05,290 --> 00:16:12,870
+Non-PKU، وفي الـHyperphenylalaninemia، وفي اللي هو الـ
+
+155
+00:16:12,870 --> 00:16:18,770
+Tetrahydrobiopterin
+
+156
+00:16:18,770 --> 00:16:26,450
+اللي هو BH4، يعني برضه Chemical Mediator
+
+157
+00:16:26,450 --> 00:16:35,130
+في ميكانيزم تبعه، النقطة هذه، فهي الفكرة إنه يعني هاي
+
+158
+00:16:35,130 --> 00:16:41,510
+على الأقل حاطين إنه فيه خمسة غير الـClassical، فيه
+
+159
+00:16:41,510 --> 00:16:47,970
+أربعة ثانيات، variant، يعني الخمسة الـClassical هو
+
+160
+00:16:47,970 --> 00:16:53,070
+الأشياء، يشيل البقية، يشيل less than one، less than
+
+161
+00:16:53,070 --> 00:16:58,990
+one، يعني الـenzyme that's affected، الأولانية اللي
+
+162
+00:16:58,990 --> 00:17:03,610
+هو الإنزيم الأولاني الـHydroxylase، وفي إنزيمات
+
+163
+00:17:03,610 --> 00:17:08,770
+ثانية بيحتاجها الجسم، بتسوي
+
+164
+00:17:08,770 --> 00:17:13,990
+مشاكل ثانية، فهذه
+
+165
+00:17:13,990 --> 00:17:19,070
+يعني هي من الأمراض الموجودة، أمراض حقيقية للواحد
+
+166
+00:17:19,070 --> 00:17:22,610
+يُعرفها، الـ
+
+167
+00:17:23,130 --> 00:17:30,830
+عبارة عن، مظهرياً هو زيادة الفينيل ألانين وإحنا
+
+168
+00:17:30,830 --> 00:17:36,330
+بنقدر ننقص مستوى الفينيل ألانين في الدم، وجزء من مراقبة المريض
+
+169
+00:17:36,330 --> 00:17:44,810
+لمرض هذا، إنه بنعمل مستوى الـAmino Acid هذا وبنشوف
+
+170
+00:17:44,810 --> 00:17:50,510
+اللولاء المصلحي، أو هل هو فعلاً ملتزم بالحِمية ولا مش
+
+171
+00:17:50,510 --> 00:17:58,700
+ملتزم، يعني حقيقةً يعني العلاج السليم لهذه الحالة
+
+172
+00:17:58,700 --> 00:18:04,300
+مفرح إن الواحد يشوف الطفل أو اللي هو بعدين يصير
+
+173
+00:18:04,300 --> 00:18:09,600
+شاب أو بنت ويكون ناجح فاعل في المجتمع وكده، كنت أنا
+
+174
+00:18:09,600 --> 00:18:14,980
+لما كنت طالب كنا نسمع عن المرض هذا قبل ما أشوفه
+
+175
+00:18:14,980 --> 00:18:22,280
+كانوا يقولوا بعد عمر السنتين إن الدماغ بيتمّ إكمال
+
+176
+00:18:22,280 --> 00:18:27,420
+نموه، يعني أهم فترة في الالتزام في الحمية وفي
+
+177
+00:18:27,420 --> 00:18:33,160
+النمو
+
+223
+00:23:11,610 --> 00:23:17,890
+عندي تصور عن إيش بيته، إنه الآن بالأخير هنا في
+
+224
+00:23:17,890 --> 00:23:24,610
+الآسيويين، هنا في الأوروبيين،  الـ31% من
+
+225
+00:23:24,610 --> 00:23:29,210
+الـMutations من هذا النوع، 11% من الـMutations من
+
+226
+00:23:29,210 --> 00:23:34,670
+هذا الشكل. خمسة خمسة خمسة، وبعدين مجموعة كبيرة
+
+227
+00:23:34,670 --> 00:23:43,650
+فيها غيرها. يعني باختصار، مثلًا زي مرض ثاني، مثل FMF،
+
+228
+00:23:43,650 --> 00:23:47,770
+«فاميل ميديتيرانيان فيفر». قمنا عليه دراسة، فعندي
+
+229
+00:23:47,770 --> 00:23:53,690
+معلومة أدق شوية عن هنا، الـDatabase تبع الـ
+
+230
+00:23:53,690 --> 00:23:58,490
+Mutations لهذه المشكلة. في حوالي، على الأقل كان فيه
+
+231
+00:23:58,490 --> 00:24:03,670
+200 ميوتاشن اللي Recognized. فهي يعني بتكون مرات
+
+232
+00:24:03,670 --> 00:24:10,450
+عدد كبير من أنواع المشاكل، وبتعطينا مضاء قد تكون
+
+233
+00:24:10,450 --> 00:24:16,750
+تفاوت في الإصابة، بتعطينا مشاكل في قضية كيف بتقول
+
+234
+00:24:16,750 --> 00:24:22,710
+وبيد الواحد يكون فاهمها، كيف يقراها في أمراض تانية.
+
+235
+00:24:28,390 --> 00:24:34,670
+زي المرض اللي دخل فيه الـ «هكسوز». «هكسوز»
+
+236
+00:24:34,670 --> 00:24:35,570
+«هكسوز» «هكسوز» «هكسوز» «هكسوز» «هكسوز»
+
+237
+00:24:35,570 --> 00:24:35,750
+«هكسوز» «هكسوز» «هكسوز» «هكسوز» «هكسوز»
+
+238
+00:24:35,750 --> 00:24:35,850
+«هكسوز» «هكسوز» «هكسوز» «هكسوز» «هكسوز»
+
+239
+00:24:35,850 --> 00:24:36,010
+«هكسوز» «هكسوز» «هكسوز» «هكسوز» «هكسوز»
+
+240
+00:24:36,010 --> 00:24:46,310
+«هكسوز» «هكسوز» «هكسوز» «هكسوز»
+
+241
+00:24:46,310 --> 00:24:54,070
+«هـ
+
+242
+00:24:54,330 --> 00:25:01,390
+الـ الـ يعني الـmetabolism steps. ففي مرض اسمه الـ
+
+243
+00:25:01,390 --> 00:25:08,370
+Tay-Sachs. عبارة عن يعني هنا الحقين مش يعني خلصنا أصلًا
+
+244
+00:25:08,370 --> 00:25:14,850
+من الموضوع. في نوع الـKetonuria واللي دخل أنه
+
+245
+00:25:14,850 --> 00:25:18,830
+بيصير amino acid metabolism anomaly. بيصير
+
+246
+00:25:18,830 --> 00:25:24,270
+excessive level of الأمينو أسيد في الجسم، وهو ضار
+
+247
+00:25:24,270 --> 00:25:31,070
+للجهاز العصبي. هنا حالة
+
+248
+00:25:31,070 --> 00:25:43,250
+ثانية. Tay-Sachs، اسم العلماء اللي اكتشفوها. بالأخير يعني
+
+249
+00:25:43,930 --> 00:25:52,270
+بيصير برضه mental retardation، procedure lens
+
+250
+00:25:52,270 --> 00:25:59,290
+problems، cherry red spots. يعني لما نيجي نبحث في عيون
+
+251
+00:25:59,290 --> 00:26:07,290
+المريض، بنلاقي إشي يعني very bright red area. وهذه
+
+252
+00:26:07,290 --> 00:26:13,890
+زي ما هنا حاطين، بتكون أكثر لأنه دخل بالـجينيتيك
+
+253
+00:26:13,890 --> 00:26:20,410
+Population معينة، بتلاقيها أكثر في الأشكنازي «جود»
+
+254
+00:26:20,410 --> 00:26:28,150
+اليهود الأشكنازيين، وبالتالي أحد أسباب الأمراض وهي
+
+255
+00:26:28,150 --> 00:26:33,990
+أيضًا اللي دخل بالـNervous System. ففيه «Tay-Sachs
+
+256
+00:26:33,990 --> 00:26:39,870
+Disease»، بس فيه له Variations. والـVariations الـ
+
+257
+00:26:39,870 --> 00:26:44,310
+يعني هنا الـgene اللي affected فيه ألفا وبيتا
+
+258
+00:26:44,310 --> 00:26:48,750
+chain. هذا على chromosome 15، هذا على chromosome 5.
+
+259
+00:26:48,750 --> 00:26:54,490
+وفيه activator ثاني مطلوب. فهنا الـAlpha Beta
+
+260
+00:26:54,490 --> 00:27:04,090
+Chain والـ هنا الـ الـ الـsubstrate، أظنني اللي هو
+
+261
+00:27:04,090 --> 00:27:09,620
+اللي بده يشتغل عليه، وفيه الـactivator، وبصير عندي الـ
+
+262
+00:27:09,620 --> 00:27:18,040
+Problem في قضية الـ الـ يعني الـMetabolic step
+
+263
+00:27:18,040 --> 00:27:22,400
+that is needed for normal function. بحيث إنه هذا
+
+264
+00:27:22,400 --> 00:27:27,860
+اللي هو نوع من الـCarbohydrate، اللي هو الـN
+
+265
+00:27:27,860 --> 00:27:33,460
+-acetylgalactosamine مع الـGalactose. فلما تكون
+
+266
+00:27:33,460 --> 00:27:38,130
+الـStructure بهذا الشكل، بيصير الـcleavage في هذا
+
+267
+00:27:38,130 --> 00:27:44,330
+الـsite نتيجة الـenzyme هذا. فأحيانًا المرض اللي
+
+268
+00:27:44,330 --> 00:27:50,150
+بنشوفه زي الـCarbohydrate Storage Problem، وزي الـ
+
+269
+00:27:50,150 --> 00:27:54,470
+Tay-Sachs Disease، الـ
+
+270
+00:27:54,470 --> 00:28:01,230
+Classical Tay-Sachs. ماشي، بيصير عندي four base
+
+271
+00:28:01,230 --> 00:28:09,540
+insertion. يعني تذكروا لما يكون insertion و
+
+272
+00:28:09,540 --> 00:28:15,460
+deletion. إذا الأمور بفواصل، ما راح يغير كتير المشكلة.
+
+273
+00:28:15,460 --> 00:28:20,540
+ماشي، إذا صار insertion لـthree nucleotides، three
+
+274
+00:28:20,540 --> 00:28:26,940
+bases، راح يزيد يعني، بيزيد one amino acid أو بنقص
+
+275
+00:28:26,940 --> 00:28:31,880
+one amino acid. مافي مشكلة. المشكلة الكبيرة اللي هي
+
+276
+00:28:31,880 --> 00:28:37,490
+لما يكون عندنا one or two. الـTotal هنا four، يعني
+
+277
+00:28:37,490 --> 00:28:43,390
+زي كأنه one base insertion. لما يصير one أو two،
+
+278
+00:28:43,390 --> 00:28:48,550
+بيسموه Frame Shift Mutation، اللي هو يعني إنه كل
+
+279
+00:28:48,550 --> 00:28:55,670
+قراءة الـProtein والـDNA راح يخرب. لأنه لما كله
+
+280
+00:28:55,670 --> 00:29:01,810
+إزاحة، راح يكون الأربعة راح تخلي كل ثلاثة. لأن الـ
+
+281
+00:29:01,810 --> 00:29:07,680
+Transfer RNA أو الـRibosomal  RNA هو
+
+282
+00:29:07,680 --> 00:29:15,460
+ثلاثات، الـCodons. لأن هنا أربعة، راح يكون فيها
+
+283
+00:29:15,460 --> 00:29:22,040
+Frame Shift Mutation. هذا راح يخرّب البروتين كله، ما
+
+284
+00:29:22,040 --> 00:29:27,520
+راح يكون functional، وراح يوقف، وراح يكون useless.
+
+285
+00:29:27,520 --> 00:29:34,300
+وبالتالي يصير عندي المرض. هذه يعني الـmechanism
+
+286
+00:29:34,300 --> 00:29:41,420
+لحالة ثانية أو مرض ثاني اسمه الـI-cell. في
+
+287
+00:29:41,420 --> 00:29:46,480
+أمراض كثيرة للـI-cell ما راح أدخل فيها، يعني مش راح
+
+288
+00:29:46,480 --> 00:29:53,280
+أدخل في كل شيء من هذا النوع.
+
+289
+00:29:53,280 --> 00:30:01,010
+في حالة ثالثة اسمها الـHomocystinuria، الـ
+
+290
+00:30:01,010 --> 00:30:08,730
+Homocysteine برضه من الـ الـ الـAmino Acid، وإله
+
+291
+00:30:08,730 --> 00:30:14,350
+دخل مع الـVitamin B12، اللي هو الـ
+
+292
+00:30:14,350 --> 00:30:22,810
+Cyanocobalamin. وإله دخل يعني في تجهيز الـ
+
+293
+00:30:22,810 --> 00:30:29,350
+الـ الـDNA replication. وإيه دخل؟ يعني هو من الـ
+
+294
+00:30:29,350 --> 00:30:33,690
+Homocysteine. بالأخير بعد الـCytosine، الـCytosine
+
+295
+00:30:33,690 --> 00:30:39,690
+اللي هو واحد من الـAmino Acid. وإيه دخل بالكولين؟
+
+296
+00:30:39,690 --> 00:30:45,410
+وإيه دخل بالـVitamin B12؟ اللي هو راح يصير نافع
+
+297
+00:30:45,410 --> 00:30:52,780
+للثيانات والـPalamine وغيرها. أظن أني في حياتي شفت
+
+298
+00:30:52,780 --> 00:31:00,200
+حالة واحدة. بالأخير بيصير Homocysteine  urea بعد ما
+
+299
+00:31:00,200 --> 00:31:04,980
+يصير يعني increased الـHomocysteine in the blood.
+
+300
+00:31:04,980 --> 00:31:12,360
+بيزيد كمان في الـexcretion بالبول. فنتيجة
+
+301
+00:31:12,360 --> 00:31:22,000
+المشكلة هذه، أنا شوفت فعلاً فيه طفل يمكن عمره
+
+302
+00:31:22,000 --> 00:31:31,220
+ثلاث سنوات، بس من ولادته صار عنده Renal stones.
+
+303
+00:31:31,220 --> 00:31:34,320
+وبتكرار،
+
+304
+00:31:34,320 --> 00:31:39,580
+يعني خلّصوه من واحدة، تصير عنده واحدة ثانية، ولحد ما
+
+305
+00:31:39,580 --> 00:31:44,200
+سوّوا له acidification of the urine، لحد ما يساعد
+
+306
+00:31:44,200 --> 00:31:48,920
+أكثر في قضية تدويب الـHomocysteine، بحيث إنه يمنع
+
+307
+00:31:48,920 --> 00:31:58,400
+قضية إنه يصير يعني precipitation للـHomocysteine
+
+308
+00:31:58,400 --> 00:32:04,500
+in the urine، ويعمل لك crystal، ويعمل لك Renal stones.
+
+309
+00:32:04,500 --> 00:32:12,810
+وبعدين يدخله في Renal failure، ومشاكل زي ذات الفكرة.
+
+310
+00:32:12,810 --> 00:32:20,070
+يعني هنا كمان قضية إنه if you know the metabolism
+
+311
+00:32:20,070 --> 00:32:25,470
+exact steps، أو كيف الـsteps that are needed،
+
+312
+00:32:25,470 --> 00:32:31,410
+أحيانًا راح نأخذها أكثر في قضية الـtreatment. بعدين
+
+313
+00:32:31,410 --> 00:32:38,030
+كيف الواحد ممكن يسوي supplementation لأشياء يعني
+
+314
+00:32:38,030 --> 00:32:50,540
+الـHomocysteine. فيه مشكلة اللي هو بـالـ اسمه
+
+315
+00:32:50,540 --> 00:32:56,000
+«سيستاثيونين سينثيز»، اللي هو الـIntermediate Maker
+
+316
+00:32:56,000 --> 00:33:00,500
+نتيجة الـMetabolism تبع الـHomocysteine. يعني فيه
+
+317
+00:33:00,500 --> 00:33:05,030
+مشكلة في الـenzyme هذه، ويكون بيستخدم فيها، يعني
+
+318
+00:33:05,030 --> 00:33:09,870
+حتى تتم الـstep هذه normally، بيرودوكسال فوسفيت،
+
+319
+00:33:09,870 --> 00:33:16,190
+اللي هو جاي من الـ.. اللي هو Vitamin B6، اللي هو
+
+320
+00:33:16,190 --> 00:33:24,250
+الـPyridoxine. الفكرة،
+
+321
+00:33:24,250 --> 00:33:29,210
+لأن هذا الـenzyme صار فيه block، بصير الـ
+
+322
+00:33:29,210 --> 00:33:35,690
+Homocysteine أكثر. بس إذا حطيت B6 supplementation
+
+323
+00:33:35,690 --> 00:33:41,590
+أكثر، بيساعد الاستفادة من التم، وبيساعد حتى الـ
+
+324
+00:33:41,590 --> 00:33:47,270
+Abnormal enzyme. وبالتالي بيخفف من أعراض المرضى،
+
+325
+00:33:47,270 --> 00:33:55,590
+فهذه أشياء زي ذلك. في حالة من الـenzyme آخر
+
+326
+00:33:58,930 --> 00:34:04,930
+ضروري لقضية تخبيط أحيانًا، Inflammatory enzymes
+
+327
+00:34:04,930 --> 00:34:09,510
+that are released. ففيه إيش اسمه Alpha-1
+
+328
+00:34:09,510 --> 00:34:15,950
+-antitrypsin. عبارة عن إنزايم، الـTrypsin اللي هو
+
+329
+00:34:15,950 --> 00:34:21,730
+عبارة عن زي الـPepsin وTrypsin، هدول اللي هو
+
+330
+00:34:21,730 --> 00:34:25,450
+digestive enzymes. الـPepsin بالأساس بيكون
+
+331
+00:34:25,450 --> 00:34:32,140
+بالمعدة، والـTrypsin اللي هو اللي بيكون من الـ
+
+332
+00:34:32,140 --> 00:34:38,680
+small intestine، ويكون على higher pH، يعني على الـ
+
+333
+00:34:38,680 --> 00:34:42,580
+alkaline environment. بحاجة لـalkaline environment.
+
+334
+00:34:42,580 --> 00:34:47,680
+فالـTrypsin إذا دخل الخلايا في الدم، محل ثاني،
+
+335
+00:34:47,680 --> 00:34:54,700
+damaging. يعني هو بخرّب البروتينات، ويكسّرها. هو الـ
+
+336
+00:34:54,700 --> 00:34:59,500
+digestive enzyme. ففي عندنا إنزايم ربنا حطه فينا
+
+337
+00:34:59,500 --> 00:35:05,040
+هذا، قضية الـAlpha-1-Antitrypsin. هو أحيانًا بيكون
+
+338
+00:35:05,040 --> 00:35:11,020
+deficient. الـdeficiency هذه راح تسبب إنه الإنسان
+
+339
+00:35:11,020 --> 00:35:17,760
+هذا يصير عنده مشكلة في قضية إنه معرّض للالتهابات
+
+340
+00:35:17,760 --> 00:35:23,280
+الرئوية.  مبتلّة بالرئتين، ويصير عنده الشيء بشكل
+
+341
+00:35:23,280 --> 00:35:29,190
+إنفزيمة، أو Bronchiectasis، أو يعني كلفت الرئتين،
+
+342
+00:35:29,190 --> 00:35:36,490
+بنسميه إنفزيمة. الملاحظ
+
+343
+00:35:36,490 --> 00:35:42,170
+هنا إن طبعًا أي مشاكل في الرئتين، من أهم الأسباب،
+
+344
+00:35:42,170 --> 00:35:49,990
+مرات كثيرة، قضية التدخين. التدخين مضر جدًا. وهنا
+
+345
+00:35:49,990 --> 00:35:58,610
+بحاول أعطيكم تصور، أهمية إنه إذا في إنسان عنده هذا
+
+346
+00:35:58,610 --> 00:36:04,030
+النوع من المشاكل، أو يعني هو الأصل، حتى لو ما عندهوش
+
+347
+00:36:04,030 --> 00:36:17,490
+الأصل، الواحد يشوف يعني قضية إنه أحسن ما يدخلش في الـ
+
+348
+00:36:17,490 --> 00:36:23,850
+Alpha-1-Antitrypsin. فيه الـO2 الـAlleles فيه شيء
+
+349
+00:36:23,850 --> 00:36:27,990
+بيقولوله الـM اللي هو Normal، والـZ اللي هو الـ
+
+350
+00:36:27,990 --> 00:36:35,270
+Abnormal. فاللي بيكون عنده ZZ بيكون معرض أكثر إنه
+
+351
+00:36:35,270 --> 00:36:45,990
+يصير عنده  Emphysema. وهنا بيبينوله إنه يعني هذه
+
+352
+00:36:45,990 --> 00:36:52,910
+الدراسة بالذات فيها يعني
+
+353
+00:36:52,910 --> 00:36:58,390
+على قضية الوفيات، وبالتالي الـSurvival هنا. فهنا
+
+354
+00:36:58,390 --> 00:37:03,570
+بيفرجونا إنه لما نكون إنسان Smoker وعنده
+
+355
+00:37:03,570 --> 00:37:10,290
+Limitations على عمر، مثلًا هنا دخلنا 50% على عمر
+
+356
+00:37:10,290 --> 00:37:14,910
+الأربعين سنة، بتوقف. طبعًا، بتكون المشاكل قبلها،
+
+357
+00:37:14,910 --> 00:37:23,410
+والمشاكل الرئوية بتكون مزمنة، وقديمة، ومستمرة، تكرار
+
+358
+00:37:23,410 --> 00:37:30,610
+الالتهابات، وإدوات تلف الرئتين. وجزء من الصورة يعني
+
+359
+00:37:30,610 --> 00:37:35,910
+إذا فيه شيء بدي إيّاكم تتذكرونه لوقت بعدين إن شاء الله
+
+360
+00:37:35,910 --> 00:37:41,730
+لما نصير أطباء واختصاصيين وكذا، إنه ذات الـAlpha-1
+
+361
+00:37:41,730 --> 00:37:49,510
+-antitrypsin، جيني الأنومالي يكون التلف في الـ
+
+362
+00:37:49,510 --> 00:37:58,430
+lower part of the lungs. يعني في مثلًا الـ
+
+363
+00:37:58,430 --> 00:38:03,610
+tuberculosis، وبتلافى الأجزاء العلوية من الـlungs
+
+364
+00:38:03,610 --> 00:38:08,350
+هي اللي فيها مشاكل أكثر. أما هنا زي ما أنتم شايفين،
+
+365
+00:38:08,350 --> 00:38:15,250
+هنا، هي أشياء غير طبيعية طبعًا، الـChest X-ray هذه،
+
+366
+00:38:15,250 --> 00:38:21,130
+بيقول فيها «hyperinflation»، يعني الرئتين مضخّمات.
+
+367
+00:38:21,130 --> 00:38:26,110
+أو الـdiaphragm، بدل ما الواحد بيشوفه بشكل سليم،
+
+368
+00:38:26,110 --> 00:38:34,670
+بيشوفه flattened، يعني مش زي قبة، مضغوط ومدفوق لتحت.
+
+369
+00:38:35,420 --> 00:38:39,640
+فهذه تغيرات، وإنه أكثر التغيرات هي في المنطقة
+
+370
+00:38:39,640 --> 00:38:45,900
+السفلية من الرئتين. فهذه حالة اسمها Alpha-1
+
+371
+00:38:45,900 --> 00:38:52,520
+-Antitrypsin Deficiency. ويعني
+
+372
+00:38:52,520 --> 00:38:58,720
+بتكون فيها مشكلة في أسئلة، سهلة الأمور. يعني إحنا
+
+373
+00:38:58,720 --> 00:39:04,370
+بدنا هيك الـMajor Things بس، يعني اللي يهمني إنه
+
+374
+00:39:04,370 --> 00:39:12,030
+يعني الواحد لما يشوف مرض
+
+375
+00:39:12,030 --> 00:39:17,990
+بهذه الطريقة، وكيف بيأثر على هذا الشيء، يتخيل الواحد
+
+376
+00:39:17,990 --> 00:39:24,170
+إنه فيه metabolic pathway، إنزيم بيصير
+
+377
+00:39:24,170 --> 00:39:29,750
+فيه مشكلة، بالأخير بنتج عنه المرض. ماشي؟ فيها سؤال؟
+
+378
+00:39:29,750 --> 00:39:31,370
+إن شاء الله الأمور واضحة.
+
+379
+00:39:38,100 --> 00:39:46,440
+تمام، إن شاء الله يا دكتور. طيب، في حالة اسمها
+
+380
+00:39:46,440 --> 00:39:54,920
+Porphyria. الـPorphyria مرض نتيجة
+
+381
+00:39:54,920 --> 00:40:04,100
+خلل الـmetabolism تبع الـhem part أو الـ
+
+382
+00:40:04,100 --> 00:40:16,800
+hemoglobin. إحنا إذا بنتذكر الـ… يعني الـHeme اللي
+
+383
+00:40:16,800 --> 00:40:21,740
+هو الـpyrrole
+
+384
+00:40:21,740 --> 00:40:26,000
+Ring اللي بيكون فيها الحديد اللي بتمسك الـOxygen
+
+385
+00:40:26,000 --> 00:40:27,700
+وجزء من الـHemoglobin.
+
+386
+00:40:29,780 --> 00:40:36,220
+بيبدأ تصنيعه بالأول بطريقة معينة، اللي هي إنه
+
+387
+00:40:36,220 --> 00:40:42,480
+الـGlycine أو Succinyl Coenzyme A مع ALA اللي هو
+
+388
+00:40:42,480 --> 00:40:48,900
+Alpha-amino
+
+389
+00:40:48,900 --> 00:40:55,960
+-delta-aminolevulinic Acid، ماشي؟ فـsynthesis هذا
+
+390
+00:40:55,960 --> 00:41:04,420
+الـEnzyme بيعطينا الـALA اللي بتتحول للـPBG، وبعدين
+
+391
+00:41:04,420 --> 00:41:08,560
+بيعطينا الـHydroxymethyl Bilane، بيعطينا الـ
+
+392
+00:41:08,560 --> 00:41:14,000
+Heme. وبصير بالعكس بعدين، له degradation في قضية
+
+393
+00:41:14,000 --> 00:41:17,360
+الـ…
+
+394
+00:41:17,360 --> 00:41:2
+
+445
+00:46:13,770 --> 00:46:18,130
+فزي ما كانت المثال اللي قبل إن الـ B6 بيكثّف
+
+446
+00:46:18,130 --> 00:46:23,150
+المشكلة هنا في أحيانًا أشياء بتزيد وفي إنتاج كتير
+
+447
+00:46:23,150 --> 00:46:35,070
+في مجموعة أمراض يعني اللي هي Familial
+
+448
+00:46:35,070 --> 00:46:41,650
+Hypercholesterolemia، الـ Cholesterol يعني من الـ
+
+449
+00:46:41,650 --> 00:46:45,390
+«موليكولز» الضرورية في بناء الخلية، من الأشياء
+
+450
+00:46:45,390 --> 00:46:50,690
+الضرورية للحياة، موجودة في الطعام وبنأكلها، بس كمان
+
+451
+00:46:50,690 --> 00:46:55,510
+الجسم بيصنعها، بيستطيع أن يصنعها، فالـ Metabolism
+
+452
+00:46:55,510 --> 00:47:10,650
+تبعها يعني مهم، وأهمية مجموعة الأمراض الناتجة عن خلل
+
+453
+00:47:10,650 --> 00:47:16,030
+الكوليسترول هو قضية، بالأخير تأثيراته على قضية
+
+454
+00:47:16,030 --> 00:47:20,630
+التصلب الشرايين، التصلب الشرايين من أشد الأمراض
+
+455
+00:47:20,630 --> 00:47:26,770
+الحالية، اللي هو مع الـ Process أو الـ Pathogenic
+
+456
+00:47:26,770 --> 00:47:30,870
+Process of Atherosclerosis، الـ Atherosclerosis
+
+457
+00:47:30,870 --> 00:47:34,510
+اللي دخل أحيانًا كتير في قضية الـ
+
+458
+00:47:36,480 --> 00:47:40,500
+الضغط والسكري، وطبعًا ارتفاع الدهون، وهذا قصد
+
+459
+00:47:40,500 --> 00:47:45,360
+الـMajor Risk Factors، زائد فيه تأثيرات Genetic
+
+460
+00:47:45,360 --> 00:47:52,720
+وFamilial، وSmoking، وMale Sex، وغيرهم وغيرهم، فالـ
+
+461
+00:47:52,720 --> 00:47:57,360
+Hypercholesterolemia، يعني الأرقام اللي عادة نتكلم
+
+462
+00:47:57,360 --> 00:48:00,440
+عنها طبعًا، إلا دخل في الـ Obesity والـ Sedentary
+
+463
+00:48:00,440 --> 00:48:04,880
+Lifestyle، والـ Metabolic Syndrome، اللي هو نتيجة
+
+464
+00:48:04,880 --> 00:48:10,060
+نمط الحياة الحديث، ناس بطلت تمشي، بطلت تتحرك
+
+465
+00:48:10,060 --> 00:48:16,720
+ولا نشطة عضلاتها وكذا، فالـ Cholesterol مهم كتير
+
+466
+00:48:16,720 --> 00:48:21,140
+والـ Cholesterol، الـ Major Risk Factor هو الـ
+
+467
+00:48:21,140 --> 00:48:24,500
+Total Cholesterol، بس لنتذكر إن الـ Cholesterol اللي
+
+468
+00:48:24,500 --> 00:48:30,300
+هو أنواع، اللي هما فيه الـ… الـBad Cholesterol اللي
+
+469
+00:48:30,300 --> 00:48:34,540
+هو Low Density Lipoprotein LDL، واللي فيه الـHigh
+
+470
+00:48:34,540 --> 00:48:37,280
+Density Lipoprotein اللي هو الـProtective أو
+
+471
+00:48:37,280 --> 00:48:43,160
+الـكويس، فيه كمان VLDL Very Low Density Lipoprotein
+
+472
+00:48:43,160 --> 00:48:49,800
+وفيه الـKylomicrons، وفيه الـTriglycerides
+
+473
+00:48:49,800 --> 00:48:56,010
+كنوع ثاني من الـLipids، ضرورية للحياة، وضرورية في
+
+474
+00:48:56,010 --> 00:49:00,290
+الجسم، فالواحد
+
+475
+00:49:00,290 --> 00:49:05,590
+يعني ما علينا، هذه الجوانب ضرورية كتير، والواحد بده
+
+476
+00:49:05,590 --> 00:49:12,090
+يتذكر الـcycle of الـcholesterol في الـbody، كيف
+
+477
+00:49:12,090 --> 00:49:16,270
+أنه بتبنى، امتصاصه في الأمعاء، في مناطق معينة، إيش
+
+478
+00:49:16,270 --> 00:49:21,670
+اسمه الـkylomicron، عبارة عن lipid globulin أو
+
+479
+00:49:21,670 --> 00:49:29,300
+lipid، يعني شنطة Lipid موجودة من الـ «تم امتصاصها»
+
+480
+00:49:29,300 --> 00:49:35,780
+في الأمعاء، وكيف أن الـLipid حتى ينتقل للجسم، بالذات
+
+481
+00:49:35,780 --> 00:49:39,740
+الـEssential Fatty Acid والـEssential Lipid، بدهم
+
+482
+00:49:39,740 --> 00:49:44,760
+Metabolism مختلف، ففي
+
+483
+00:49:44,760 --> 00:49:47,340
+مجموعة ناس بتلاقي عندهم «فميليا»
+
+484
+00:49:47,340 --> 00:49:51,260
+الـHypercholesterolemia، بتكون أرقام الـ«كوليسترول»
+
+485
+00:49:51,260 --> 00:49:56,740
+very high، طبعاً إحنا الـ Hypercholesterolemia جزء
+
+486
+00:49:56,740 --> 00:50:01,660
+من، حتى سريريًا ممكن واحد يشوف فيه، زي ما إن شاء الله
+
+487
+00:50:01,660 --> 00:50:06,600
+تاخدوا في قضايا الطب السريري، فيه اللي هو الـ Arcus
+
+488
+00:50:06,600 --> 00:50:12,340
+Lipidus، والـ Xanthlasmas، والـ Xanthomas، عبارة عن
+
+489
+00:50:12,340 --> 00:50:17,220
+يعني بتشوف على المريض، في عينيه، حوالين الجسم، على
+
+490
+00:50:17,220 --> 00:50:23,640
+الكوع أو على جسمه، بتلاقي في عنده ترسبات دهنية،
+
+491
+00:50:23,640 --> 00:50:28,280
+ماشي؟ وهذه اللي بتدخل أنه يصير عند الواحد تصلب شرايين
+
+492
+00:50:28,280 --> 00:50:36,260
+فالـ Familial Form، ماشي؟ ونتيجة هذا الجزء منه
+
+493
+00:50:36,260 --> 00:50:46,120
+نتيجة فهمنا لـ Metabolism، لكيفية الجسم بتعامل مع
+
+494
+00:50:46,120 --> 00:50:51,320
+الـLipids اللي بيمتصها من الأمعاء، إحنا بنبدأ الأول
+
+495
+00:50:51,320 --> 00:50:55,400
+الـ «كايلو مايكرونز»، وبعدين بتتحول، لما نأخذ منها
+
+496
+00:50:55,400 --> 00:51:00,700
+شوية كوليسترول أكثر، بيصير الـVLDL، وبعدين بيصير
+
+497
+00:51:00,700 --> 00:51:11,400
+الـLDL، في كوليسترول أكثر، الـLDL بتم امتصاصه مع اللي
+
+498
+00:51:11,400 --> 00:51:17,370
+هو الـLDL Receptor على الخلايا، وأنه فيه أبوبروتين
+
+499
+00:51:17,370 --> 00:51:23,270
+B100 اللي هو الـCholesterol Ester Core، وبعدين
+
+500
+00:51:23,270 --> 00:51:26,710
+بيصير Internalization، وبالتالي بنزل نسبة
+
+501
+00:51:26,710 --> 00:51:32,270
+الـCholesterol في الدم، فبالنسبة
+
+502
+00:51:32,270 --> 00:51:38,070
+للفميليا الـHypercholesterolemia، فيه أكثر من نوع
+
+503
+00:51:38,070 --> 00:51:42,410
+على الأقل الـMajor ones، أربعة، طبعًا، دولة من
+
+504
+00:51:42,410 --> 00:51:46,860
+الـEuropean descent، في مثلًا الـItalian، ومدينة
+
+505
+00:51:46,860 --> 00:51:51,100
+الـEastern، من كيف بيصير هيك في الصينيين، إشي في
+
+506
+00:51:51,100 --> 00:51:55,920
+السود، إشي في كذا، ودول الأنواع، إشي اللي دخل
+
+507
+00:51:55,920 --> 00:52:03,820
+الـLDL-Receptor، أو الـApoprotein B100، أو الـARH
+
+508
+00:52:03,820 --> 00:52:10,920
+-Adapter Protein، أو الـPCSK9-Protease، بيصير يعني
+
+509
+00:52:10,920 --> 00:52:15,030
+loss of function، أو gain of function، وفي الغالب هما
+
+510
+00:52:15,030 --> 00:52:18,310
+autosomal dominant، إلا إذا بعض فيه أشياء autosomal
+
+511
+00:52:18,310 --> 00:52:25,350
+recessive، الطبيعي يعني
+
+512
+00:52:25,350 --> 00:52:30,110
+إحنا الـ optimal cholesterol level، بالmilligram
+
+513
+00:52:30,110 --> 00:52:35,450
+per deciliter، الطبيعي لإنسان ما عندهوش مشكلة، ويعني
+
+514
+00:52:35,450 --> 00:52:39,190
+مش مريض، بعيش عادي، مش خائفين من قضية
+
+515
+00:52:39,190 --> 00:52:44,460
+الـAtherosclerosis، نقبل لحد الميتين، إذا كان عند
+
+516
+00:52:44,460 --> 00:52:47,420
+الواحد one two risk factors، الـ optimal يكون تحت
+
+517
+00:52:47,420 --> 00:52:53,180
+الـ 160، إذا فيه عنده مشكلة، وإن بده يصير تصلب شرايين
+
+518
+00:52:53,180 --> 00:52:57,500
+بدنا إياها تحت الـ 130، فالفميليا الـ
+
+519
+00:52:57,500 --> 00:53:03,160
+hypercholesterolemia، الـ homozygous one في الـ LDL
+
+520
+00:53:03,160 --> 00:53:09,600
+receptor، عادةً بيكون حوالي 700، بينما إذا
+
+521
+00:53:09,600 --> 00:53:14,910
+heterozygous، وصل 350، الـ Normal Adult حاطينه لحد
+
+522
+00:53:14,910 --> 00:53:20,510
+الـ 120، يعني يمكن دراسات أجدد، وكل مكان أنزل أحسن
+
+523
+00:53:20,510 --> 00:53:26,950
+ففي عائلات بتلاقي، وبتلاقي عندهم مشكلة، لأن الـ
+
+524
+00:53:26,950 --> 00:53:30,890
+cholesterol very high، وبالتالي مع ال other risk
+
+525
+00:53:30,890 --> 00:53:35,450
+factors، بتخلي ال atherosclerosis يصير بشكل سريع
+
+526
+00:53:35,450 --> 00:53:42,290
+إذا بتلاقي عيلة فيها جلطات
+
+527
+00:53:43,240 --> 00:53:49,960
+في القلب، جلطات على الدماغ، جلطات وتصلب شرايين
+
+528
+00:53:49,960 --> 00:53:54,640
+وحطوا شبكات ومشاكل زي هيك، في جزء منه التدخين
+
+529
+00:53:54,640 --> 00:53:58,820
+والضغط السكري صحيح، بس عامل مهم كتير الـ
+
+530
+00:53:58,820 --> 00:54:03,640
+Hypercholesterolemia، بالذات Familial، وفيه الآن
+
+531
+00:54:03,640 --> 00:54:09,680
+يعني دراسات على قضية الـ Mutations اللي بتسببها
+
+532
+00:54:09,680 --> 00:54:16,650
+الـ، إمتى بنفكر في الموضوع هذا؟ جزء منه لما يكون الـ
+
+533
+00:54:16,650 --> 00:54:20,990
+cholesterol very high، يعني زي لما تشوف رقم زي 700
+
+534
+00:54:20,990 --> 00:54:27,370
+وبعدين بسأل عن أهل المريض وأقاربه، وشو أوضاعهم،
+
+535
+00:54:27,370 --> 00:54:32,490
+إذا بلاقي إشي زي هيك، بالغالب هذه المشكلة، فهنا
+
+536
+00:54:32,490 --> 00:54:38,950
+هاي مثال على level، حكينا إنه الإنسان الطبيعي يعني
+
+537
+00:54:38,950 --> 00:54:45,820
+هو أنا حاطي 160، 120، 180، كيف أن الـ… الـ… الـ…
+
+538
+00:54:45,820 --> 00:54:50,520
+الـHeterozygous بالأربعمائة، الـHomozygous
+
+539
+00:54:50,520 --> 00:54:57,020
+بالسبعمائة، يعني مع أن يعني حتى في ملاحظة لهذول
+
+540
+00:54:57,020 --> 00:55:03,180
+الـHyperlipidemia، لما يكون لما
+
+541
+00:55:03,180 --> 00:55:11,140
+يكون الـLevel very very very high، حتى يعني أحياناً
+
+542
+00:55:11,140 --> 00:55:15,850
+بنلاقي الظاهرة هذه، وإحنا نسحب الدم بتلاقيك وإنت
+
+543
+00:55:15,850 --> 00:55:24,370
+تسحب دم المريض، بتلاقي الدم مش لونه طبيعي، عكر
+
+544
+00:55:24,370 --> 00:55:29,630
+كأنه حليبي صار، يعني فعلاً بتلاقي فيه دهون موجود
+
+545
+00:55:29,630 --> 00:55:37,310
+بزيادة، وبتكون نتيجة مشكلة هذا الموضوع، فالـ Low
+
+546
+00:55:37,310 --> 00:55:41,010
+-Density Lipoprotein له
+
+547
+00:55:43,510 --> 00:55:49,150
+Different forms of mutations، والموضوع اللي دخل
+
+548
+00:55:49,150 --> 00:55:54,310
+في الـ Familial hypercholesterolemia، وإلها أنواع
+
+549
+00:55:54,310 --> 00:56:04,350
+وأشكال وكذا، بده الواحد يكون يعرف عنها الأنواع
+
+550
+00:56:04,350 --> 00:56:11,130
+المختلفة، يعني بشكل عام هذه المشكلة
+
+551
+00:56:12,860 --> 00:56:19,060
+في حالة أخرى اسمها «cystic fibrosis»، «cystic
+
+552
+00:56:19,060 --> 00:56:30,440
+fibrosis»، يعني برضه اللي هو في الغالب «autosomal
+
+553
+00:56:30,440 --> 00:56:33,640
+recessive»
+
+554
+00:56:33,640 --> 00:56:39,440
+«cystic fibrosis»، حالة
+
+555
+00:56:40,800 --> 00:56:47,820
+هي من أسباب أو قريبة من الـ، تشتركت تقريبًا مع
+
+556
+00:56:47,820 --> 00:56:52,700
+حكينا عن موضوع الـ Alpha-1-Antitrypsin Deficiency
+
+557
+00:56:52,700 --> 00:56:58,080
+بتسبب برضه مشكلة بالنسبة للرئتين مبكرة، يعني اللي
+
+558
+00:56:58,080 --> 00:57:04,400
+بيكون إنسان أو طفل أو عائلة عندها أفراد بتصير
+
+559
+00:57:04,400 --> 00:57:10,370
+عندهم تكرار في حدوث التهاب الرئتين، بيكون مشكلة في
+
+560
+00:57:10,370 --> 00:57:18,430
+قضية الـ… بيكون قضية أحيانًا الـcystic fibrosis
+
+561
+00:57:18,430 --> 00:57:25,930
+الـ… الـcystic fibrosis بتعمل مشكلة في الرئتين
+
+562
+00:57:25,930 --> 00:57:32,270
+نتيجة تكرار الجهد، وممكن تعطينا مشكلة، يعني تخريب في
+
+563
+00:57:32,270 --> 00:57:38,050
+الرئتين، وبتعمل مشكلة، إنه حتى بالنسبة لو وظيفة
+
+564
+00:57:38,050 --> 00:57:42,390
+البنكرياس، بيصير فيها مشكلة، لو بيصير malabsorption
+
+565
+00:57:42,390 --> 00:57:49,450
+بيصير مشاكل سوء هضم، growth retardation، بيصير مشكلة
+
+566
+00:57:49,450 --> 00:57:59,990
+فيها، لما درسوا الموضوع، فيه very important يعني
+
+567
+00:57:59,990 --> 00:58:05,850
+بالأخير gene، اللي هو سميناها بعدين «cystic fibrosis
+
+568
+00:58:05,850 --> 00:58:11,610
+transporter receptor gene»، اللي هو «CFTR»، هذا
+
+569
+00:58:11,610 --> 00:58:21,830
+عبارة عن موليكيول كبير، وظيفته إنه بيعمل exchange
+
+570
+00:58:21,830 --> 00:58:27,930
+between الصوديوم والبوتاسيوم والكالسيوم، حوالين على
+
+571
+00:58:27,930 --> 00:58:34,150
+الـ cell wall، يعني هو اللي بيكون بالأخير بتحكم في
+
+572
+00:58:34,150 --> 00:58:41,650
+قضية إدخال وإخراج الـ… هدول الـ… الـIons
+
+573
+00:58:41,650 --> 00:58:48,490
+الـPositive Ions من الـCell، فالـ…
+
+574
+00:58:48,490 --> 00:58:54,350
+زي ما هوّ موضّح لكم هنا، الـCFTR، وحطينا Capital،
+
+575
+00:58:54,350 --> 00:59:01,450
+الـCapital هي للـGene، ماشي؟ فعطينا الـCFTR، بالأول
+
+576
+00:59:01,450 --> 00:59:07,550
+الـ In-between اللي هو الـ RNA، Messenger RNA
+
+577
+00:59:07,550 --> 00:59:18,350
+وبعدين بيعطينا البروتين الـ CFTR، جين له Exons، فالـ
+
+578
+00:59:18,350 --> 00:59:27,270
+Exons 23 Exons، ماشي، الـ Exons هم اللي بدخلوا
+
+579
+00:59:27,270 --> 00:59:31,780
+في التركيب البروتين، والـ introns in between are
+
+580
+00:59:31,780 --> 00:59:38,220
+removed at the stage of the messenger RNA، البروتين
+
+581
+00:59:38,220 --> 00:59:48,220
+الأخير هو Complex، يعني هو بوابة لتنقل
+
+582
+00:59:48,220 --> 01:00:00,470
+الـ ions في الـ cell membrane، فبيجي تركيبه هيك، فالـ
+
+583
+01:00:00,470 --> 01:00:05,830
+Cystic Fibrosis، يعني إيش دخل في الـ Lungs، إيش دخل
+
+584
+01:00:05,830 --> 01:00:11,670
+في الـ Pancreas، وفي الـ GI، الفحص السريري عندنا بتذكر
+
+585
+01:00:11,670 --> 01:00:17,490
+أستاذ إيش اللي كنا في الكويت، كان يقول شخصة Cystic
+
+586
+01:00:17,490 --> 01:00:24,250
+Fibrosis، لأنه أم الطفل مولود حديث بتقول يا دكتور
+
+587
+01:00:24,250 --> 01:00:33,300
+عرق الطفل مالح كتير، شايفة إن ملوحته زايدة كتير، كانت
+
+588
+01:00:33,300 --> 01:00:38,780
+اللي لما إنها بيسموه chloride sweat test، يعني
+
+589
+01:00:38,780 --> 01:00:44,580
+عبارة عن test، إنه بيخلوا، بيبقوا يعني بيحطوا زي
+
+590
+01:00:44,580 --> 01:00:49,840
+منشفة، على منشفة غير منفذة على الطفل، وبيخلوه يعرق
+
+591
+01:00:51,090 --> 01:00:55,750
+وبيجمعوا العرق تبعه، بيشوفوا مستوى الملح فيه، وهذا
+
+592
+01:00:55,750 --> 01:01:01,690
+بيسموه chloride sweat test، أو sweat chloride test
+
+593
+01:01:01,690 --> 01:01:06,410
+إذا أكثر من ستين، أقل من ستين، بنقول أرقام، وبنعرف
+
+594
+01:01:06,410 --> 01:01:16,420
+عنها، فالـعبارة عن Complex Protein اللي دخل في الـ
+
+595
+01:01:16,420 --> 01:01:24,840
+Cell Membrane، بالأخير بتحكم بإدخال وإخراج الـ Ions
+
+596
+01:01:24,840 --> 01:01:29,540
+from and into the cell، فاللي دخل في الـ Secretions
+
+597
+01:01:29,540 --> 01:01:34,520
+واللي دخل في وظائف الرئتين، والبكرياس، فهنا في حالة
+
+598
+01:01:34,520 --> 01:01:40,910
+اسمها Cystic Fibrosis، وبيحاولوا يساعدوهم، وبيحاولوا
+
+599
+01:01:40,910 --> 01:01:47,530
+يعني يدرسوا الموضوع هذا، في حالات أخرى، زي مثلًا الـ
+
+600
+01:01:47,530 --> 01:01:51,550
+Duchenne Muscular Dystrophy، الـ Duchenne عبارة عن
+
+601
+01:01:51,550 --> 01:02:00,430
+مرض في تركيب من العضلات، بيكون حجم العضلات كبير، بس
+
+602
+01:02:00,430 --> 01:02:05,090
+ضعيف، يعني بتحسّه يسمونه pseudo-hypertrophy، pseudo
+
+603
+01:02:05,090 --> 01:02:11,950
+يعني كاذب، يعني بيكون في ضعف العضلات، ويمكن تكلمنا
+
+604
+01:02:11,950 --> 01:02:17,410
+مرة من قبل عنه، تبارعًا الـ protein مطلوب للـ
+
+605
+01:02:17,410 --> 01:02:24,670
+action of the muscles، واسمه، دول الأمراض
+
+606
+01:02:28,410 --> 01:02:32,630
+يعني الـGenetic، وهيكون إلها أكتر من نوع، وفيه إشي
+
+607
+01:02:32,630 --> 01:02:37,870
+اسمه «بكر»، «Muscular Dystrophy»، أخف، وبيبدأ بشكل
+
+608
+01:02:37,870 --> 01:02:44,630
+متأخر عن الـClassical «دوشين»، اتكلمنا عنهم وقلنا، وإلّه فيه مشاكل
+
+609
+01:02:44,630 --> 01:02:49,130
+وفيه أكثر من نوع، قضية الـ«دوشين»، في الـ
+
+610
+01:02:49,130 --> 01:02:55,790
+Achondroplasia، أو Osteogenesis imperfecta، برضه من
+
+611
+01:02:55,790 --> 01:03:00,390
+الأمراض الأخرى في العظام، Osteogenesis
+
+612
+01:03:00,390 --> 01:03:09,730
+imperfecta، اللي هو فيه مشكلة الـ Type 1 collagen
+
+613
+01:03:09,730 --> 01:03:14,370
+genes، برضه، يعني هرجع لكم مرة صورة عنها، هتذكرها
+
+614
+01:03:14,370 --> 01:03:21,610
+لأنّه لما كنت في التدريب السريري، وأنا طالب، كان عندنا
+
+615
+01:03:21,610
+
+667
+01:08:37,850 --> 01:08:41,490
+يعني فيه بتعطي مشاكل كثيرة نتيجة الـMitochondrial
+
+668
+01:08:41,490 --> 01:08:47,710
+Disease. لها أنواع كثيرة، وزي ما أنتم شايفين
+
+669
+01:08:47,710 --> 01:08:51,810
+يعني أهم شيء فيها اللي هي إنه الـInheritance
+
+670
+01:08:51,810 --> 01:09:01,170
+maternal فقط، ما بيقول فيه شو اسمه يكون دخل بالنسبة
+
+671
+01:09:01,170 --> 01:09:07,420
+للأب يعطي الحالة. هذا يعني مش غلط،  دِلوَاقِت واحد بيشوف يعني
+
+672
+01:09:07,420 --> 01:09:12,480
+إنسان عنده بالذات ضعف عضلات، اشتعال في العصاب بشكل
+
+673
+01:09:12,480 --> 01:09:19,980
+يعني ليش أقول مميز أو غريب بالذات لما يكون فيه
+
+674
+01:09:19,980 --> 01:09:30,140
+تاريخ عائلي. يجب أن يكون أحد يتذكر هذه الأشياء فيه
+
+675
+01:09:30,140 --> 01:09:38,470
+كمان أمراض وحالات ثانية يكون الـMechanism قضية مش
+
+676
+01:09:38,470 --> 01:09:41,610
+في الـCoding DNA. يعني احنا كثير من الأشياء اللي
+
+677
+01:09:41,610 --> 01:09:46,570
+اتكلمنا عنها عبارة عن أمثلة عن أنه الـProtein
+
+678
+01:09:46,570 --> 01:09:49,930
+بيكون فيه مشكلة نتيجة أنه الـGene فيه مشكلة
+
+679
+01:09:49,930 --> 01:10:01,770
+أحيانًا في أمراض وحالات بيكون المشكلة في الـ يعني
+
+680
+01:10:01,770 --> 01:10:12,170
+بعد ما تصير قضية الـ يعني الحالات هنا بتكون repeat
+
+681
+01:10:12,170 --> 01:10:19,270
+اللي هو Tri-nucleotide repeat disease، اللي هي إنه
+
+682
+01:10:19,270 --> 01:10:24,990
+بيصير خلل على مستوى، أوضح على مستوى الـRNA، فيه
+
+683
+01:10:24,990 --> 01:10:27,650
+Myotonic Dystrophy و Huntington disease
+
+684
+01:10:27,650 --> 01:10:33,310
+وFriedreich's ataxia و Fragile X Syndrome العادية
+
+685
+01:10:33,310 --> 01:10:40,010
+و الـTremor Ataxia Syndrome. يعني عبارة عن ملاحظة أن
+
+686
+01:10:40,010 --> 01:10:44,190
+أهم شيء تقريبًا العصاب هي اللي لدينا مشكلة فيها
+
+687
+01:10:44,190 --> 01:10:49,310
+و الـHuntington's Disease مرعب يعني للإنسان
+
+688
+01:10:49,310 --> 01:10:52,950
+ولعائلته. والله يحمينا، مش من الأشياء اللي
+
+689
+01:10:52,950 --> 01:11:01,030
+كتير لدينا منها مشاكل. أتمنى أن أكون يعني غطيت بشكل
+
+690
+01:11:01,030 --> 01:11:10,790
+يعني بأعطيكم هيك بعض المعلومات بشكل مفيد لإيش
+
+691
+01:11:10,790 --> 01:11:19,070
+أمراض من هذه الناحية، وإذا حد عنده أسئلة يسأل.
+
+692
+01:11:19,070 --> 01:11:26,470
+أنا يعني بعد قليل عندي التزام ثاني، محاضرة ثانية
+
+693
+01:11:27,020 --> 01:11:34,080
+فهذا الـSpectrum أو هذه الأمثلة
+
+694
+01:11:34,080 --> 01:11:40,460
+اللي بيحاولوا يفرجّوكم فيها بدايةً إيش الخلل في
+
+695
+01:11:40,460 --> 01:11:45,380
+الجيل، على إيش المؤثر، وفي الأخير كيف بعطينا المرض
+
+696
+01:11:45,380 --> 01:11:48,960
+لأن
+
+697
+01:11:48,960 --> 01:11:57,640
+الـ "هيس" قال أنا بتوقع السؤال راح يكون على المطلوب،
+
+698
+01:11:57,640 --> 01:12:04,080
+مش مطلوب، مش عارف إيه، إيش، كده يعني لما الواحد
+
+699
+01:12:04,080 --> 01:12:11,960
+يكون على اطلاع على كيف هذه الحالات بتصير، وشو الـ
+
+700
+01:12:11,960 --> 01:12:18,260
+Mechanism تبعها، وكيف بتكون، بيكون الواحد إن شاء
+
+701
+01:12:18,260 --> 01:12:21,960
+الله طبيب ودكتور أحسن. فيه أسئلة؟
+
+702
+01:12:24,620 --> 01:12:31,100
+كأنني شفت إنه فيه الـ "تشات" أو الـ
+
+703
+01:12:31,100 --> 01:12:35,680
+"تشات". أنا
+
+704
+01:12:35,680 --> 01:12:44,960
+اللي بيهمني يعني هي أمور مش للحفظ بالذات الـ
+
+705
+01:12:44,960 --> 01:12:49,200
+"metabolic steps" أو كده، بقدر ما إنه مثلًا نوعية
+
+706
+01:12:49,200 --> 01:12:53,160
+الـEnzymes اللي إيش هي، على أي شيء بتشتغل، ما هو
+
+707
+01:12:53,160 --> 01:12:59,800
+اسم الـ"إنزايم"، بقول لك على إيش بيشتغل. يعني في نوع
+
+708
+01:12:59,800 --> 01:13:04,340
+الألانين مثلًا "هيدروكسيلز" ولا "سينثيز" ولا شيء
+
+709
+01:13:04,340 --> 01:13:13,320
+يعني إيه دخل بالأماكن
+
+710
+01:13:13,320 --> 01:13:19,560
+التفرات؟ لأ، ما فيش حد ممكن يحفظ أماكن التفرات زي
+
+711
+01:13:19,560 --> 01:13:23,800
+ما حكيت في أمثلة كثيرة. عدد التفرات كبير جدًا، هائل
+
+712
+01:13:23,800 --> 01:13:27,820
+جدًا.  في الأخير كلهم بيخربوا نفس الـEnzyme بطرق مختلفة
+
+713
+01:13:27,820 --> 01:13:32,780
+أو نفس البروتين بيخربّوه بطرق مختلفة. الـAlzheimer
+
+714
+01:13:32,780 --> 01:13:39,300
+له ثمن كبير، وممكن يكون مميت طبعًا. يعني نفسه نفسه
+
+715
+01:13:39,300 --> 01:13:47,340
+الإنسان بعد يعني هو الإنسان فقط كجسم لأ، يعني القلب
+
+716
+01:13:47,340 --> 01:13:52,120
+والرئتين بيشتغل، جزء من الدماغ يعني بالـBrain
+
+717
+01:13:52,120 --> 01:13:59,090
+Stem بتحكم بالأشياء اللي هي الضرورية، وهذول بتبقى
+
+718
+01:13:59,090 --> 01:14:03,070
+شغالة، ما بتتأثر. أما الـAlzheimer بيأثر على
+
+719
+01:14:03,070 --> 01:14:09,130
+إنسانية الإنسان، على دماغه من ناحية الـHigher
+
+720
+01:14:09,130 --> 01:14:13,650
+Mental Functions، الشخصية،
+
+721
+01:14:13,650 --> 01:14:24,760
+اللغة، الذكاء، التعامل الاجتماعي، كذا. الإنسان يعني
+
+722
+01:14:24,760 --> 01:14:32,140
+بتمنى وبرغب دائمًا إنه يكون مستقل، يكون إنه هو يعني
+
+723
+01:14:32,140 --> 01:14:41,420
+هو مستقل وهو يقدر يعمل، يعيش بحياته. أنا مضطر هسّه
+
+724
+01:14:41,420 --> 01:14:47,820
+أترك، ماشي. وبنكمل يوم الأربعاء، عشان أقول للطلاب
+
+725
+01:14:47,820 --> 01:14:54,600
+يعطيك ألف عفو يا دكتور. أهلاً وسهلاً. نعم لأ هو خارج
+
+726
+01:14:54,600 --> 01:14:59,560
+المحاضرة خلاص. مش مشكلة، خير. الله يعطيك ألف عفو يا
+
+727
+01:14:59,560 --> 01:15:03,840
+دكتور. الله يحيكم. أهلاً وسهلاً. نشوفكم على خير إن شاء
+
+728
+01:15:03,840 --> 01:15:04,040
+الله
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/u_JvIjOn4A0_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/u_JvIjOn4A0_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..d66bd4565f2f79fcbca4f57f8560f9ec3a962d69
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/u_JvIjOn4A0_raw.srt
@@ -0,0 +1,2912 @@
+1
+00:00:02,080 --> 00:00:09,880
+الـ Share أمورنا
+
+2
+00:00:09,880 --> 00:00:19,600
+كويسة في شباب وداخلين أربعة لسه طيب نبدأ
+
+3
+00:00:19,600 --> 00:00:24,320
+زي كل مرة في الأول في أسئلة على الأشياء اللي تم
+
+4
+00:00:24,320 --> 00:00:28,240
+نقاشها من قبل في حد عنده سؤال في الوراقة
+
+5
+00:00:33,750 --> 00:00:42,310
+إذا في حد عنده سؤال يعني يتكلم بس إحنا يعني
+
+6
+00:00:42,310 --> 00:00:46,450
+بالنسبة لمحاضرة اليوم اللي كان المفروض الأسبوع
+
+7
+00:00:46,450 --> 00:00:51,470
+اللي فات وكان فيها مشكلة بالنسبة انقطعت الكهربا
+
+8
+00:00:51,470 --> 00:00:59,950
+واتخرّبت الأمور إحنا ندخل الآن في أمثلة متعددة عن
+
+9
+00:00:59,950 --> 00:01:11,770
+أنواع من الأمراضالوراطية ونحاول نعمل شرح عن يعني
+
+10
+00:01:11,770 --> 00:01:20,570
+مسبباتها وأنواع الطفرات، أنواع الأليات الـ
+
+11
+00:01:20,570 --> 00:01:29,910
+Mechanisms لتسبب بهذه الأمراض الوراطية صراحة يعني
+
+12
+00:01:29,910 --> 00:01:36,500
+الـالليست طويلة، القائمة طويلة من الأمراض اللي
+
+13
+00:01:36,500 --> 00:01:44,680
+حاطينها في الكتاب وأنا يعني اللي بديها من ناحية
+
+14
+00:01:44,680 --> 00:01:53,540
+تانية، من ناحية الأولى اللي هي إن الواحد يعني لما
+
+15
+00:01:53,540 --> 00:01:59,480
+تقوله يتطلع على القائمة هذه وعلى الأقل هي نسبياً
+
+16
+00:01:59,480 --> 00:02:04,650
+بالنسبة لعدد الأمراضالوراثية المعروفة هي لسة قصيرة
+
+17
+00:02:04,650 --> 00:02:14,750
+جداً وإشي يعني قليل كثير ولكن الأمراض في الـ في
+
+18
+00:02:14,750 --> 00:02:22,930
+الحياة وعند أي population إذا حنتشوف بتلاقوا أمراض
+
+19
+00:02:22,930 --> 00:02:31,860
+متنوعة وكثير كثير فبدي أنه الواحد يكون عندهيعني
+
+20
+00:02:31,860 --> 00:02:37,380
+قدرة على إنه لما يعرف إنه فيه مرض فلاني كيف يرجع
+
+21
+00:02:37,380 --> 00:02:42,660
+لمرجع يعني الآن أنا بستخدم كثير الـInternet
+
+22
+00:02:42,660 --> 00:02:48,500
+وGoogle على أساس الـOnline Source
+
+23
+00:02:48,500 --> 00:02:55,620
+للـGenetic Mendelian Diseases وبشوف، بقرا عن شُو
+
+24
+00:02:55,620 --> 00:03:00,740
+كاتبين عن الموضوع هذافيعني الواحد يربي نفسه أو
+
+25
+00:03:00,740 --> 00:03:07,380
+يعلم حاله على إنه يقدر يرجع لمرجع معين يقرأ عن أي
+
+26
+00:03:07,380 --> 00:03:12,820
+مرض وكذا، والمطلوب التاني إنه يقدر الواحد إيش هي
+
+27
+00:03:12,820 --> 00:03:17,420
+الـGenetic Mechanism أتكلمنا على أنواع مشاكل
+
+28
+00:03:17,420 --> 00:03:27,780
+كثيرة، فنتكلم عنهم يعني قصدي على أنواع المشاكلاللي
+
+29
+00:03:27,780 --> 00:03:36,020
+بتعمل مشاكل في الوراطة وبتكون أمراض وراطية فيه
+
+30
+00:03:36,020 --> 00:03:43,700
+كأنه مؤتز رافع إيده أو إشي؟
+
+31
+00:03:43,700 --> 00:03:51,440
+لأ تمام الأمور بالتأكيد طيب بالنسبة لكتابكم
+
+32
+00:03:52,520 --> 00:03:56,960
+حاطط الـ… الـ… طبعاً احنا أخدنا بالمحاضرة اللي
+
+33
+00:03:56,960 --> 00:04:01,040
+فاتت السابقة الـHemoglobinopathies واتكلمنا على
+
+34
+00:04:01,040 --> 00:04:06,560
+أنواعهم وسمينا الـSicklers والـParsimias والأنواع
+
+35
+00:04:06,560 --> 00:04:12,540
+التانية وأخدناهم كشيء يعني متخصص درسنا أنواع
+
+36
+00:04:12,540 --> 00:04:19,940
+الـGenetic Mutations اللي بتعملهم كترتيب
+
+37
+00:04:19,940 --> 00:04:25,220
+للمجموعةالأمراض اللي حاططها وانا بقدر هنا يعني
+
+38
+00:04:25,220 --> 00:04:30,100
+حاطط لكم تقريبًا دي أربعة، ستة، اتنين، أربعة، عشرة
+
+39
+00:04:30,100 --> 00:04:35,400
+يعني حاططت خمسة وعشرين، تلاتين المرض تقريبًا طالب
+
+40
+00:04:35,400 --> 00:04:41,160
+انكم على الأقل يكون الواحد منكم عارف إيش هي وإيش
+
+41
+00:04:41,160 --> 00:04:45,300
+نوعية المشكلة اللي موجودة فيها وكيف ال
+
+42
+00:04:48,260 --> 00:04:55,120
+فهن الآن التفرات أو الأمراض الوراثية أو الأليات
+
+43
+00:04:55,120 --> 00:05:01,440
+اللي تسببت في المرض هذا فطريقة تقسيم الكتاب
+
+44
+00:05:01,440 --> 00:05:08,820
+بالنسبة لهذا الموضوع إنه حاكتهم على شكل يعني
+
+45
+00:05:08,820 --> 00:05:17,720
+مجموعات ضمن تركيب الخلية ففي مجموعة أمراض بتكون
+
+46
+00:05:17,720 --> 00:05:22,240
+فيها مشاكل في الـ organelles العضييات اللي جوا
+
+47
+00:05:22,240 --> 00:05:26,760
+القضية أو أولهم الـ mitochondria فحاطين liver
+
+48
+00:05:26,760 --> 00:05:32,340
+liver hereditary optic neuropathy وفي LD1 protein
+
+49
+00:05:32,340 --> 00:05:39,320
+أو electron transport chain defects فحاطت أمثلة
+
+50
+00:05:39,320 --> 00:05:44,140
+Transition Translation of the mitochondrial
+
+51
+00:05:44,140 --> 00:05:52,050
+proteinsزي الـ Mylas إحنا راح ناخد واحد منهم ونشوف
+
+52
+00:05:52,050 --> 00:05:57,730
+يعني هيكون هو شارع يفترض إنه الواحد منكم لما نقرأ
+
+53
+00:05:57,730 --> 00:06:00,870
+صحيح يعني يمكن المرض الواحد ماشوفش ولا حالة منه
+
+54
+00:06:01,330 --> 00:06:07,790
+بكون هذا يعني مزعج
+
+55
+00:06:07,790 --> 00:06:15,310
+أو يعني حالة يعني بسبب ضعف اللي الواحد يفهم شو هو
+
+56
+00:06:15,310 --> 00:06:21,380
+المرض يعني مش زي لما نيش كون شاب حالةوفي الـ
+
+57
+00:06:21,380 --> 00:06:26,740
+Paroxysomes زي الـ Zolliger's Syndrome اللي هي فيه
+
+58
+00:06:26,740 --> 00:06:32,240
+12 بروتين أو الـ Lysosomes زي الـ Tysax Disease أو
+
+59
+00:06:32,240 --> 00:06:35,920
+الـ Hurler's Syndrome في الـ Extracellular
+
+60
+00:06:35,920 --> 00:06:41,080
+Proteins الـ Transplant زي حكينا الـ Globulin في
+
+61
+00:06:41,080 --> 00:06:43,600
+الـ Hemoglobin زي الـ Sickles الأنيميا أو
+
+62
+00:06:43,600 --> 00:06:47,960
+التلسينيا الـ Morphogenes اللي هي زي
+
+63
+00:06:53,290 --> 00:07:00,950
+Follow انسفلوباتي، انتهاب الدماغ، انتسيم أو Alpha
+
+64
+00:07:00,950 --> 00:07:04,510
+-1-antitrypsin deficiency زي البروتيز انهيبتر
+
+65
+00:07:05,100 --> 00:07:11,740
+Hemostasis زي الـHemophilia A وB الـHormones زي
+
+66
+00:07:11,740 --> 00:07:14,960
+الإنسوين في الـRare Forms بتعتودي أبيتس
+
+67
+00:07:14,960 --> 00:07:20,520
+الـCollagen زي الـCollagen Type I Disease
+
+68
+00:07:20,520 --> 00:07:26,340
+الـOestrogenesis Imperfecta الـComplement زي
+
+69
+00:07:26,340 --> 00:07:31,080
+الـHereditary Angioneurotic بقديمة Complement
+
+70
+00:07:31,080 --> 00:07:35,480
+After Hالحققانة اللي هو الـ Age-related macular
+
+71
+00:07:35,480 --> 00:07:40,980
+degeneration الـ Metabolic enzymes زي الـ Pq فنع
+
+72
+00:07:40,980 --> 00:07:47,240
+الكيتون أيوريا اللي هو الفنع الأناني الـ disease
+
+73
+00:07:47,240 --> 00:07:51,120
+أو الـ Adenosine Deaminase اللي هو السبب للـ SCID
+
+74
+00:07:51,120 --> 00:07:54,820
+Severe Combined Immune Deficiency أو Duchene
+
+75
+00:07:54,820 --> 00:08:01,340
+Muscular Dystrophin بسبب مشكلة الدستروفينأو بالـ
+
+76
+00:08:01,340 --> 00:08:07,300
+Nucleus itself زي الـ Aniridia اللي هي أنه مافيش
+
+77
+00:08:07,300 --> 00:08:14,200
+Iris فيه مشكلة Brachia 102 اللي هم دخل بالكانسر
+
+78
+00:08:14,200 --> 00:08:21,410
+Hereditary Non-polyposis Colon CancerDNA mismatch،
+
+79
+00:08:21,410 --> 00:08:25,890
+repair of proteins، fragile eggs syndrome،
+
+80
+00:08:25,890 --> 00:08:34,430
+retinoblastoma، مشكلة السرطان ومشكلة الشبكية،
+
+81
+00:08:34,430 --> 00:08:42,750
+الـCML، الفرديل فيه كرومزوم، الـcell surface زي
+
+82
+00:08:42,750 --> 00:08:48,170
+الـandrogen insensitivity أو الـachondroplasia
+
+83
+00:08:50,380 --> 00:08:54,460
+أو الـ Hypercholesterolemia أو الـ Cystic Fibrosis
+
+84
+00:08:54,460 --> 00:08:57,560
+أو الـ Type 1 Diabetes يعني هذه الأمثل اللي بدنا
+
+85
+00:08:57,560 --> 00:09:03,300
+ناخدها إذا
+
+86
+00:09:03,300 --> 00:09:09,300
+بدنا نحاول نشوف أو إذا كان هو شارع كتير بس بدي
+
+87
+00:09:09,300 --> 00:09:15,160
+يكون الواحد لما يقرأ تفاصيل المرض بدي نحاول إن
+
+88
+00:09:15,160 --> 00:09:21,520
+احنا نوصل اليوم فيه إنه كيفالاختلال الجين أدى
+
+89
+00:09:21,520 --> 00:09:25,900
+للمظهر اللي عندنا وشوهي الاختلالات اللي كانت في
+
+90
+00:09:25,900 --> 00:09:33,720
+الجينات من أي ناحية وكيف نتجت عنها الأمراض
+
+91
+00:09:33,720 --> 00:09:41,200
+هذه بدنا نتذكر أنه يعني الآن صحيح الجين في الغالب
+
+92
+00:09:41,200 --> 00:09:45,000
+مش قطعة واحدة في Exons and Trons بحيث أنه أحنا
+
+93
+00:09:45,000 --> 00:09:52,620
+بحاجةإنه أدت قطع بالأخير تمت إلى قضية الـ
+
+94
+00:09:52,620 --> 00:09:58,600
+Transcription لتنطلق الـ RNA فحتى تعرف آلية الخلية
+
+95
+00:09:58,600 --> 00:10:04,840
+من أين تبدأ أو أين تتوقف لازم فيه Control لازم فيه
+
+96
+00:10:04,840 --> 00:10:10,000
+آليات تحكم ففي منطقة الـ Promoter Region الـ
+
+97
+00:10:10,000 --> 00:10:18,360
+Startup Cordon فيه آليات وفيهأشياء حتى تنشط هذا
+
+98
+00:10:18,360 --> 00:10:23,860
+الـ Gene وتبقى تعرف من وين تبدأ و لوين تتوقف فهذه
+
+99
+00:10:23,860 --> 00:10:29,120
+آلية قد تصعب نفس الـ Gene قد تحدث ليه مشكلة بعد
+
+100
+00:10:29,120 --> 00:10:33,720
+هيك لما يطلع الـ Messenger RNA بدي تم عليه شغل
+
+101
+00:10:33,720 --> 00:10:39,690
+أحياناً الشغل هذا هو اللي بيكون فيه مشكلةالحال
+
+102
+00:10:39,690 --> 00:10:48,910
+الأولى اللي بتكلموا عنها إشي اسمه الـ Penile
+
+103
+00:10:48,910 --> 00:10:58,130
+Pitoneuria الـ PQ الـ PQ مرض يعني تقريبًا يعني
+
+104
+00:10:58,130 --> 00:11:03,510
+أحنا بالأردن ما بين 300 لـ 800 مصاب فيهيعني
+
+105
+00:11:03,510 --> 00:11:08,630
+تقريبًا واحد بالألف وواحد بالثلاثمية وواحد
+
+106
+00:11:08,630 --> 00:11:17,690
+بالخمسمية فيه تفاوت في الـ فيه تفاوت في النسب
+
+107
+00:11:17,690 --> 00:11:22,870
+وخصوصًا إنه بالذات مع الـ Consanguinity زواج
+
+108
+00:11:22,870 --> 00:11:27,770
+الأقارب يكون نسبة الحدود أكبر بكتير إبارة عن
+
+109
+00:11:27,770 --> 00:11:30,050
+بالأخير مجموعة
+
+110
+00:11:33,810 --> 00:11:38,770
+«بيوكيميكال باثوية» «anomalies» «التي ستؤدي إلى
+
+111
+00:11:38,770 --> 00:11:44,230
+الهيبرفنال الألانين» الفنال الألانين أحد الـ Amino
+
+112
+00:11:44,230 --> 00:11:53,150
+Acid إذا بزيد كثير بعمل مشكلة بالدرجة بالنسبة للـ
+
+113
+00:11:53,150 --> 00:11:57,590
+nervous system development يعني بيصير أنه ليس
+
+114
+00:11:57,590 --> 00:12:02,810
+الجهاز العصبي في خللفي الـClassical ones الشعرهم
+
+115
+00:12:02,810 --> 00:12:07,610
+بيكون على لون أحمر شوية هي في لونه شوية مختلف مميز
+
+116
+00:12:07,610 --> 00:12:14,590
+نوعاً ما بس يمكن يولدوا في الغالب نتيجة أنه الفناء
+
+117
+00:12:14,590 --> 00:12:20,450
+الأنانين في خلال فترة الحمل يعني بتتم التحكم فيه
+
+118
+00:12:20,450 --> 00:12:28,630
+كمان عن طريق الأم هي انه ممكن لو ارتفعيتم تنزيله
+
+119
+00:12:28,630 --> 00:12:35,330
+عن طريق الـ Metabolism تبع الأم بعد
+
+120
+00:12:35,330 --> 00:12:40,270
+الولادة بتظل مرتفع وبتصير فيه مشكلة الـ
+
+121
+00:12:40,270 --> 00:12:47,090
+phenylalanine is metabolized by a hydroxylase it
+
+122
+00:12:47,090 --> 00:12:52,610
+will change it from phenylalanine to tyrosine فهذه
+
+123
+00:12:52,610 --> 00:12:57,830
+النقطة الأساسيةفالـ Phenylalanine Hydrolase هو
+
+124
+00:12:57,830 --> 00:13:03,870
+الإنزايم على أقل في الـ Classical PQ الحلوف
+
+125
+00:13:03,870 --> 00:13:09,990
+أو الملاحظة على الـ PQ اللي هو قضية إنه الـ
+
+126
+00:13:09,990 --> 00:13:17,270
+Treatment تبعته وبذلك عشان نحافظ على الـ Mental
+
+127
+00:13:17,270 --> 00:13:21,770
+Capacityيعني it is a major cause of preventable
+
+128
+00:13:21,770 --> 00:13:29,130
+mental retardation يعني التخلف العقلي ونمو الدماغ
+
+129
+00:13:29,130 --> 00:13:36,810
+في الإنسان إذا تم التنبه لهذه الحالة وعلاجها أو
+
+130
+00:13:36,810 --> 00:13:41,010
+التعامل معاها بالطريقة السليمة اللي هي عن طريق الـ
+
+131
+00:13:41,010 --> 00:13:44,330
+Low Phenyl Alanine Diet يعني اللي هو Low Protein
+
+132
+00:13:44,330 --> 00:13:50,160
+Diet الفنال الألانين موجود فيمجموعة بروتينات
+
+133
+00:13:50,160 --> 00:13:57,220
+وبالتالي لما نكون نعطي نصائح وفيه يعني literature
+
+134
+00:13:57,220 --> 00:14:06,440
+وواضح شوهي الأكلات اللي في تونس فيها يعني الخبز،
+
+135
+00:14:06,440 --> 00:14:10,480
+الدرة،
+
+136
+00:14:10,480 --> 00:14:12,780
+البقوليات
+
+137
+00:14:14,800 --> 00:14:18,060
+الأجبان، يعني كلها بتصير ممنوعة لأن فيها نسبة
+
+138
+00:14:18,060 --> 00:14:25,760
+عالية من البراتين وبالتالي الأهل يعني هي مشكلة ليش
+
+139
+00:14:25,760 --> 00:14:32,140
+أقول يعني دائمة بس مشكلة طويلة بالنسبة للعائلة
+
+140
+00:14:32,140 --> 00:14:36,700
+اللي بيكون عندها مصابين من ناحية إنه بدهم يتفهوا
+
+141
+00:14:36,700 --> 00:14:44,420
+لأكلهم وقضية إن الواحد يوكل أكليعني مخصص مش قضية
+
+142
+00:14:44,420 --> 00:14:54,140
+سهلة يعني بحاجة لـ بحاجة لـ علم و بحاجة لتنبؤ و
+
+143
+00:14:54,140 --> 00:14:59,960
+بحاجة لإرادة و بحاجة لدعم من المجتمع على قضية يعني
+
+144
+00:14:59,960 --> 00:15:05,440
+إحنا في أردن جمعية الـ BQ جمعية الـ Penal Ketone
+
+145
+00:15:05,440 --> 00:15:13,440
+الأردنية أنا عضو فيهاويعني بنوفر الأكلات اللي هي
+
+146
+00:15:13,440 --> 00:15:21,720
+قليلة الملعق قليلة البروتين بعضها يعني ممكن نفس
+
+147
+00:15:21,720 --> 00:15:29,160
+الإنسان يتعامل معها يعني كل الـ كل
+
+148
+00:15:29,160 --> 00:15:31,580
+الورقيات
+
+149
+00:15:32,220 --> 00:15:37,840
+يعني ملوقي، بخص بقدونس، أشياء زي ذلك، فيه أشياء
+
+150
+00:15:37,840 --> 00:15:43,660
+مسموعة وهذه ممكن الإنسان يوقعها وما بتأثرش فالـ
+
+151
+00:15:43,660 --> 00:15:49,360
+بالنسبة للتفرات
+
+152
+00:15:49,360 --> 00:15:58,860
+المتوقعة ثبت بعدين إنه عبارة عن أكثر من نوع وفي
+
+153
+00:15:58,860 --> 00:16:05,290
+عندنا الـ Classical BBQوفي الـ Variant PQ وفي الـ
+
+154
+00:16:05,290 --> 00:16:12,870
+Non-PQ وفي الـ Hyperpylananemia وفي اللي هو الـ
+
+155
+00:16:12,870 --> 00:16:18,770
+Tetrahydrobiopetrine
+
+156
+00:16:18,770 --> 00:16:26,450
+اللي هو BH4 يعني برضه Chemical Mediator
+
+157
+00:16:26,450 --> 00:16:35,130
+في ميكانزم تبعالنقطة هذه فهي الفكرة إنه يعني هاي
+
+158
+00:16:35,130 --> 00:16:41,510
+على الأقل حاطين إنه فيه خمس غير الـ Classical فيه
+
+159
+00:16:41,510 --> 00:16:47,970
+أربع تانيات variant يعني الخمس الـ Classical هو
+
+160
+00:16:47,970 --> 00:16:53,070
+الأشياء يشيل البقية يشيل less than one less than
+
+161
+00:16:53,070 --> 00:16:58,990
+one يعني الـ enzyme that's affectedالأولانيات اللي
+
+162
+00:16:58,990 --> 00:17:03,610
+هو الفلع الأولاني الـ Hydroxylase وفي إنزيمات
+
+163
+00:17:03,610 --> 00:17:08,770
+تانية بحاجة للجسم بتسوي
+
+164
+00:17:08,770 --> 00:17:13,990
+مشاكل تانية فهذه
+
+165
+00:17:13,990 --> 00:17:19,070
+يعني هي من الأمراض الموجودة أمراض حقيقية للواحد
+
+166
+00:17:19,070 --> 00:17:22,610
+بعرفها الـ
+
+167
+00:17:23,130 --> 00:17:30,830
+عبارة عن مظهريًا هو زيادة الفنع الأنانين وإحنا
+
+168
+00:17:30,830 --> 00:17:36,330
+بنقدر نقيص مستوىها في الدم وجزء من مراقبة المريض
+
+169
+00:17:36,330 --> 00:17:44,810
+لمرض هذا إنه بنعمل مستوى الـ Amino Acid هذا وبنشوف
+
+170
+00:17:44,810 --> 00:17:50,510
+اللواء المصل أو هل هو فعلاً ملتزم بالحمية ولا مش
+
+171
+00:17:50,510 --> 00:17:58,700
+ملتزمويعني حقيقةً يعني العلاج السليم لهذه الحالة
+
+172
+00:17:58,700 --> 00:18:04,300
+مفرح إن الواحد يشوف الطفل أو اللي هو بعدين يصير
+
+173
+00:18:04,300 --> 00:18:09,600
+شاب أو بنت ويكون ناجح فاعل في المجتمع وكده كنت أنا
+
+174
+00:18:09,600 --> 00:18:14,980
+لما كنت طالب كنا نسمع عن المرض هذا قبل ما أشوفه
+
+175
+00:18:14,980 --> 00:18:22,280
+كانوا يقولوا بعد عمر السنتين إن الدماغ بيتماستكمال
+
+176
+00:18:22,280 --> 00:18:27,420
+نموه، يعني أهم فترة في الالتزام في الحمياء وفي
+
+177
+00:18:27,420 --> 00:18:33,160
+النمو الطبيعي للجهاز العصبي والدماغ اللي هو أول
+
+178
+00:18:33,160 --> 00:18:38,200
+سنتين في الحياة، فإنه بعدين يعني بيقدر المريض
+
+179
+00:18:38,200 --> 00:18:43,300
+يترافى ويوفي الأشياء عادية، بس ثبت إنه لأ لازم يظل
+
+180
+00:18:43,300 --> 00:18:47,780
+على الحمياء لأنه ممكن ينفذ تخلف عقلي وضرر على
+
+181
+00:18:47,780 --> 00:18:53,700
+الدماغحتى لو بعدين و أكون في فترة تانية فصراحة إن
+
+182
+00:18:53,700 --> 00:18:59,100
+الواحد كمجتمع يتنبه لهذه الحالة ويدعم العائلة اللي
+
+183
+00:18:59,100 --> 00:19:03,860
+عندها المرض هذا طبعا إنه مايتزوجوش من بعض من ناحية
+
+184
+00:19:03,860 --> 00:19:09,720
+و ينصحهم بس كمان قضية توفيرة الأكل خصوصا كثير منهم
+
+185
+00:19:09,720 --> 00:19:15,180
+فقرا أو كثير منهم يعني تجد صعوبة إنه يلاقوا الواحد
+
+186
+00:19:15,180 --> 00:19:20,770
+الأكل المناسب والحقيقيونتيجتها إنه يشوف الواحد
+
+187
+00:19:20,770 --> 00:19:26,730
+الطفل يكون ويصل إنه يكون منتج سليم، معافى، يكون
+
+188
+00:19:26,730 --> 00:19:32,050
+يعني يكون
+
+189
+00:19:32,050 --> 00:19:39,790
+يخلص جامعة، يشتغل بشكل طبيعي، هذه كلها إشي مفيدة
+
+190
+00:19:39,790 --> 00:19:50,970
+الفكرة في الموضوع إنه الـالنوعية المشاكل اللي
+
+191
+00:19:50,970 --> 00:19:59,790
+بتسوي الـ PQ هنا حاطي
+
+192
+00:19:59,790 --> 00:20:04,630
+لكم إنه في البيض نوعية الـ Genetic Variations
+
+193
+00:20:04,630 --> 00:20:12,670
+مختلفة عن الـ ASIA ماشي وهذه قضية بتكون إنه درسوا
+
+194
+00:20:15,180 --> 00:20:20,040
+درسوا الـ Variation طبعًا دولة الـ Classical أتوقع
+
+195
+00:20:20,040 --> 00:20:26,320
+بالـ Classical PQ وبيكونوا
+
+196
+00:20:26,320 --> 00:20:32,140
+يعني حاطينها
+
+197
+00:20:32,140 --> 00:20:37,860
+في حسب ده الواحد قام بدراسة إنه جاب العائلة وفيها
+
+198
+00:20:37,860 --> 00:20:42,320
+مصابين وفيها طبعًا الأب والأم لأن هذا Autosomal
+
+199
+00:20:42,320 --> 00:20:47,030
+Recessiveالأب والأم يكونوا حاملين للمرضى وبالتالي
+
+200
+00:20:47,030 --> 00:20:50,570
+هو «autism recessive» يبين بالـ «females» والـ
+
+201
+00:20:50,570 --> 00:20:54,410
+«females» بتبعض ويكونوا بيشتغلوا بهذه الطريقة
+
+202
+00:20:54,410 --> 00:21:02,570
+الفكرة، لما يحطوا لكم أرقام زي هذه، ناشي؟ يعني
+
+203
+00:21:02,570 --> 00:21:08,510
+مثلًا في أكبر نوع من المشاكل في الـEuropean
+
+204
+00:21:08,510 --> 00:21:19,760
+patientsوانه هنا حوالي 4000 حالة أو 4000 يعني
+
+205
+00:21:19,760 --> 00:21:24,920
+Individual مصاب R408W
+
+206
+00:21:24,920 --> 00:21:34,620
+الـ «R» والـ «W» بدكم تتذكروا هدولة اللي يعني بدنا
+
+207
+00:21:34,620 --> 00:21:43,400
+نتذكر اللي هم الـ Amino Acidsوبكونوا يعني اللي هو
+
+208
+00:21:43,400 --> 00:21:49,880
+الـ Amino acid بتقلهم أكتر من طريقة للكتابة فممكن
+
+209
+00:21:49,880 --> 00:21:56,540
+واحد يكتب Phenylalanine كـ Amino acid يكتبه كامل
+
+210
+00:21:56,540 --> 00:22:01,220
+وفيه بيحطوا ثلاث أحرف وفيه بيرمزولهم بحرف واحد،
+
+211
+00:22:01,220 --> 00:22:06,280
+فيبقى الأخيرإذا بالواحد بيرجع للجدول بيشوف شو الـ
+
+212
+00:22:06,280 --> 00:22:12,180
+«R» بتمثل أنه Amino Acid ماشي و «W» Amino Acid
+
+213
+00:22:12,180 --> 00:22:19,480
+تاني فاللي بيصير أنه بدل كده بيجي كده فبدي أقول في
+
+214
+00:22:19,480 --> 00:22:25,740
+عندنا Substitution لـAmino Acid الـ408 هي
+
+215
+00:22:25,740 --> 00:22:30,700
+الـLocation تبعة الـAmino Acid Substitution هذافهي
+
+216
+00:22:30,700 --> 00:22:36,800
+عبارة عن One letter amino acid code is used في هذه
+
+217
+00:22:36,800 --> 00:22:42,820
+الناحية والـ Position اللي صارت في الـ mutation هم
+
+218
+00:22:42,820 --> 00:22:48,960
+بيحكيوكوا معاها مثل هي بتكون في الغالب زي الموضوع
+
+219
+00:22:48,960 --> 00:22:54,040
+مثلا الـ Sickle cell اللي في الـ Position 6 في الـ
+
+220
+00:22:54,040 --> 00:23:00,350
+Valine صار بدل الـالـ Arginine أو اللي هو الـ
+
+221
+00:23:00,350 --> 00:23:04,970
+Amino Acid اللي صار فيه اختلاف، ماشي؟ طبعاً هدولة
+
+222
+00:23:04,970 --> 00:23:11,610
+مش مطلبات لقدر ما أنه لما أنا أشوف الرمز هذا أكون
+
+223
+00:23:11,610 --> 00:23:17,890
+عندي تصور عن إيش بيته، إنه الآن بالأخير هنا في
+
+224
+00:23:17,890 --> 00:23:24,610
+الـAsians، هنا في الـEuropeans الـ 31% من
+
+225
+00:23:24,610 --> 00:23:29,210
+الـMutation من هذا النوع11% من الـ Mutations من
+
+226
+00:23:29,210 --> 00:23:34,670
+هذا الشكل تست خمسة خمسة خمسة وبعدين مجموعة كبيرة
+
+227
+00:23:34,670 --> 00:23:43,650
+فيها غيرها يعني باختصار مثلا زي مرض تاني مثل FMF
+
+228
+00:23:43,650 --> 00:23:47,770
+«فاميل الميداترانيان تيفر» قمنا عليه دراسة فعندي
+
+229
+00:23:47,770 --> 00:23:53,690
+معلومة أدقة شوية عن هنا الـ Database تبع الـ
+
+230
+00:23:53,690 --> 00:23:58,490
+Mutations لهذه المشكلة في حواليعلى الأقل كان فيه
+
+231
+00:23:58,490 --> 00:24:03,670
+200 ميوتاشيا اللي Recognized فهي يعني بتكون مرات
+
+232
+00:24:03,670 --> 00:24:10,450
+عداد كبيرة من أنواع المشاكل وبتعطينا مضاء قد تكون
+
+233
+00:24:10,450 --> 00:24:16,750
+تفاوت في الإصابة بتعطينا مشاكل في قضية كيف بتقول
+
+234
+00:24:16,750 --> 00:24:22,710
+وبيد الواحد يكون فاهمها كيف يقراها في أمراض تانية
+
+235
+00:24:28,390 --> 00:24:34,670
+زي المرض اللي دخل فيه الـ «هيكسوز» «هيكسوز»
+
+236
+00:24:34,670 --> 00:24:35,570
+«هيكسوز» «هيكسوز» «هيكسوز» «هيكسوز» «هيكسوز»
+
+237
+00:24:35,570 --> 00:24:35,750
+«هيكسوز» «هيكسوز» «هيكسوز» «هيكسوز» «هيكسوز»
+
+238
+00:24:35,750 --> 00:24:35,850
+«هيكسوز» «هيكسوز» «هيكسوز» «هيكسوز» «هيكسوز»
+
+239
+00:24:35,850 --> 00:24:36,010
+«هيكسوز» «هيكسوز» «هيكسوز» «هيكسوز» «هيكسوز»
+
+240
+00:24:36,010 --> 00:24:46,310
+«هيكسوز» «هيكسوز» «هيكسوز» «هيكسوز»
+
+241
+00:24:46,310 --> 00:24:54,070
+«هي
+
+242
+00:24:54,330 --> 00:25:01,390
+الـ الـ يعني الـ metabolism steps ففي مرض اسمه الـ
+
+243
+00:25:01,390 --> 00:25:08,370
+Tysacs عبارة عن يعني هنا الحقين مش يعني خلصنا اصلا
+
+244
+00:25:08,370 --> 00:25:14,850
+من الموضوع الـ في نوع الـ Ketonuria واللي دخل انه
+
+245
+00:25:14,850 --> 00:25:18,830
+بيصير amino acid metabolism anomaly بيصير
+
+246
+00:25:18,830 --> 00:25:24,270
+excessive level of الـأمينو أسد في الجسم، وهو مخطط
+
+247
+00:25:24,270 --> 00:25:31,070
+للعصب مخطط للنظام، ضار للجهاز العصبي هنا حالة
+
+248
+00:25:31,070 --> 00:25:43,250
+ثانية Tyset اسم العلماء اللي اكتشفوها بالأخير يعني
+
+249
+00:25:43,930 --> 00:25:52,270
+بيصير برضه mental retardation procedure lens
+
+250
+00:25:52,270 --> 00:25:59,290
+problems cherry red spots يعني لما نيجي نبحث عيون
+
+251
+00:25:59,290 --> 00:26:07,290
+المريض بنلاقي إشي يعني very bright red area وهذه
+
+252
+00:26:07,290 --> 00:26:13,890
+زي ما هنا حاطين بتكون أكتر لأنه دخل بالـجينيتيك
+
+253
+00:26:13,890 --> 00:26:20,410
+Population معينة بتلاقيها أكتر في الأشكنازي «جود»
+
+254
+00:26:20,410 --> 00:26:28,150
+اليهود الأشكنازيين وبالتالي أحد أسباب الأمراض وهي
+
+255
+00:26:28,150 --> 00:26:33,990
+أيضًا اللي دخل بالـ Nervous System ففيه «Tysiac
+
+256
+00:26:33,990 --> 00:26:39,870
+Disease» بس فيه له Variations والـ Variationsالـ
+
+257
+00:26:39,870 --> 00:26:44,310
+يعني هنا الـ gene اللي affected فيه ألفة و Beta
+
+258
+00:26:44,310 --> 00:26:48,750
+chain هذا على chromosome 15 هذا على chromosome 5
+
+259
+00:26:48,750 --> 00:26:54,490
+وفيه activator تاني مطلوب فهنا الـ Alpha Beta
+
+260
+00:26:54,490 --> 00:27:04,090
+Chain والـ هنا الـ الـ ال substrate أظنني اللي هو
+
+261
+00:27:04,090 --> 00:27:09,620
+بدي يشتغل عليه وفيه ال activator وبصير عنديالـ
+
+262
+00:27:09,620 --> 00:27:18,040
+Problem في قضية الـ الـ يعني الـ Metabolic step
+
+263
+00:27:18,040 --> 00:27:22,400
+that is needed for normal function بحيث إنه هذا
+
+264
+00:27:22,400 --> 00:27:27,860
+اللي هو النوع من الـ Carbohydrate اللي هو الـ M
+
+265
+00:27:27,860 --> 00:27:33,460
+-acetylgalactosamine مع الـ Galactose فلما تكون
+
+266
+00:27:33,460 --> 00:27:38,130
+الـ Structure بهذا الشكلوبيصير الـ cleavage في هذا
+
+267
+00:27:38,130 --> 00:27:44,330
+الـ site نتيجة الـ enzyme هذا فأحياناً المرض اللي
+
+268
+00:27:44,330 --> 00:27:50,150
+بنشوفه زي الـ Carbohydrate Stroke Problem وزي الـ
+
+269
+00:27:50,150 --> 00:27:54,470
+Tysax Disease الـ
+
+270
+00:27:54,470 --> 00:28:01,230
+Classical Tysax ماشي بيصير عندي four base
+
+271
+00:28:01,230 --> 00:28:09,540
+insertion يعني حكيناتتذكروا لما يكون insertion و
+
+272
+00:28:09,540 --> 00:28:15,460
+deletion إذا الأمور فلفات ما راح يغير كتير المشكلة
+
+273
+00:28:15,460 --> 00:28:20,540
+ماشي إذا صار insertion لـ three nucleotides three
+
+274
+00:28:20,540 --> 00:28:26,940
+bases راح يقول يعني بزيد one amino acid أو بنقص
+
+275
+00:28:26,940 --> 00:28:31,880
+one amino acid مافي مشكلة المشكلة الكبيرة اللي هي
+
+276
+00:28:31,880 --> 00:28:37,490
+لما يكون عندنا one or twoالـ Total هنا Four يعني
+
+277
+00:28:37,490 --> 00:28:43,390
+زي كأنه One Base Insertion لما يصير One أو Two
+
+278
+00:28:43,390 --> 00:28:48,550
+بيسموه Frame Shift Mutation اللي هو يعني إنه كل
+
+279
+00:28:48,550 --> 00:28:55,670
+قراءة الـ Protein والـ DNA راح يخرب لأنه لما كله
+
+280
+00:28:55,670 --> 00:29:01,810
+إفدا راح يكون الأربعة راح تخلي كل ثلاثة لأن الـ
+
+281
+00:29:01,810 --> 00:29:07,680
+Trans cellأو الـ Ribosomal وTransferral RNA هو
+
+282
+00:29:07,680 --> 00:29:15,460
+ثلاثات الـ Codons لأن هنا أربعة راح يكون فيها
+
+283
+00:29:15,460 --> 00:29:22,040
+Frame Shift Mutation هذا راح تخرّب البروتين كله ما
+
+284
+00:29:22,040 --> 00:29:27,520
+راح يكون functional وراح يوقف وراح يكون useless
+
+285
+00:29:27,520 --> 00:29:34,300
+وبالتالي يصير عند المرضفهذه يعني الـ mechanism
+
+286
+00:29:34,300 --> 00:29:41,420
+لحالة تانية أو مرض تاني اسمه الـ Ticeps في
+
+287
+00:29:41,420 --> 00:29:46,480
+أمراض كثيرة للـ I-cell ما اندخل فيها، يعني مش راح
+
+288
+00:29:46,480 --> 00:29:53,280
+أدخل في كل شيء من النوع
+
+289
+00:29:53,280 --> 00:30:01,010
+الأمراض في حالة ثالثة اسمها الـ Homocystinuriaالـ
+
+290
+00:30:01,010 --> 00:30:08,730
+Homocysteine برضه من الـ الـ الـ Amino Acid وإله
+
+291
+00:30:08,730 --> 00:30:14,350
+دخل مع الـ Vitamin B12 اللي هو الـ
+
+292
+00:30:14,350 --> 00:30:22,810
+Cyanocopamolamine وإله دخل يعني في التجهيزلـ الـ
+
+293
+00:30:22,810 --> 00:30:29,350
+الـ الـ DNA replication وإيه دخل؟ يعني هو من الـ
+
+294
+00:30:29,350 --> 00:30:33,690
+Homocystein بالأخير بعد الـ Cytosine الـ Cytosine
+
+295
+00:30:33,690 --> 00:30:39,690
+اللي هو واحد من الـ Amino Acid وإيه دخل بالكوليت؟
+
+296
+00:30:39,690 --> 00:30:45,410
+وإيه دخل بالـ Vitamin B12؟ اللي هو راح يصير نفع
+
+297
+00:30:45,410 --> 00:30:52,780
+السيانات والـ Palamine وغيرهاأظن أني في حياتي شُفت
+
+298
+00:30:52,780 --> 00:31:00,200
+حالة واحدة بالأخير بيصير homocysteine urea بعد ما
+
+299
+00:31:00,200 --> 00:31:04,980
+يصير يعني increased الـ«هوموسيستيل» in the blood
+
+300
+00:31:04,980 --> 00:31:12,360
+بزيد كمان في الـexecration بالورين فنتيجة
+
+301
+00:31:12,360 --> 00:31:22,000
+المشكلة هذهكان أنا شوفت فعلاً فيه طفل يمكن عمره
+
+302
+00:31:22,000 --> 00:31:31,220
+تلت سنوات بس من ولادته صار عنده Renal stones
+
+303
+00:31:31,220 --> 00:31:34,320
+وبتكرار
+
+304
+00:31:34,320 --> 00:31:39,580
+يعني خلصوه من واحدة تصير عنده واحدة تانية ولحد ما
+
+305
+00:31:39,580 --> 00:31:44,200
+صوّنا له acidification of the urineلحد ما يساعد
+
+306
+00:31:44,200 --> 00:31:48,920
+أكتر في قضية تدويب الـ Homocysteine بحيث إنه منع
+
+307
+00:31:48,920 --> 00:31:58,400
+قضية إنه يصير يعني precipitation للـ Homocysteine
+
+308
+00:31:58,400 --> 00:32:04,500
+in the urine ويعملّك crystal ويعملّك Renal stones
+
+309
+00:32:04,500 --> 00:32:12,810
+وبعدين تدخله في Renal failure ومشاكل زي ذاتالفكرة
+
+310
+00:32:12,810 --> 00:32:20,070
+يعني هنا كمان قضية إنه if you know the metabolism
+
+311
+00:32:20,070 --> 00:32:25,470
+exact steps أو كيف الـ steps that are needed
+
+312
+00:32:25,470 --> 00:32:31,410
+أحياناً راح ناخدها أكتر في قضية ال treatment بعدين
+
+313
+00:32:31,410 --> 00:32:38,030
+كيف الواحد ممكن يسوي supplementation لأشياء يعني
+
+314
+00:32:38,030 --> 00:32:50,540
+الـ homocysteineفيه مشكلة اللي هو بـ الـ اسمه
+
+315
+00:32:50,540 --> 00:32:56,000
+«ستافايونين سينتيز» اللي هو الـ Intermediate Maker
+
+316
+00:32:56,000 --> 00:33:00,500
+نتيجة الـ Metabolism تبع الـHemocysteine يعني فيه
+
+317
+00:33:00,500 --> 00:33:05,030
+مشكلة في الـEnzyme هذهوهيكون بيستخدم فيها، يعني
+
+318
+00:33:05,030 --> 00:33:09,870
+حتى تتم الـ step هذه normally بيردوكسال بوسفيت
+
+319
+00:33:09,870 --> 00:33:16,190
+اللي هو جاي من ال .. اللي هو vitamin B6 اللي هو
+
+320
+00:33:16,190 --> 00:33:24,250
+الـ Birodioxin فالفكرة،
+
+321
+00:33:24,250 --> 00:33:29,210
+لأن هذا الـ enzyme صار فيه blockفبصير الـ
+
+322
+00:33:29,210 --> 00:33:35,690
+Homocystein أكتر بس إذا حطيت B6 supplementation
+
+323
+00:33:35,690 --> 00:33:41,590
+أكتر بيساعد الاستفادة من التم وبساعد حتى الـ
+
+324
+00:33:41,590 --> 00:33:47,270
+Abnormal enzyme وبالتالي بيخفف من أعراض المرضى،
+
+325
+00:33:47,270 --> 00:33:55,590
+فهذه أشياء زي ذلك في حالة من الـ enzyme آخر
+
+326
+00:33:58,930 --> 00:34:04,930
+ضروري لقضية تخبيط أحيانًا Inflammatory enzymes
+
+327
+00:34:04,930 --> 00:34:09,510
+that are released ففيه إيش اسمه Alpha-1
+
+328
+00:34:09,510 --> 00:34:15,950
+-antitrypsin عبارة عن إنزايم الـTrypsin اللي هو
+
+329
+00:34:15,950 --> 00:34:21,730
+عبارة عن زي الـPepsin وTrypsin هدولة اللي هو
+
+330
+00:34:21,730 --> 00:34:25,450
+digestive enzymes الـPepsin بالأسد بيكون
+
+331
+00:34:25,450 --> 00:34:32,140
+بالاستمتاعوالـ Trypsin اللي هو اللي بيكون من الـ
+
+332
+00:34:32,140 --> 00:34:38,680
+small intestine ويكون على higher pH يعني على الـ
+
+333
+00:34:38,680 --> 00:34:42,580
+alkaline environment بحاجة لـ alkaline environment
+
+334
+00:34:42,580 --> 00:34:47,680
+فالـ Trypsin إذا جوا الخلايا في الدم محل تاني
+
+335
+00:34:47,680 --> 00:34:54,700
+damaging يعني هو بيخرّب البروتينات وبيكسبها هو الـ
+
+336
+00:34:54,700 --> 00:34:59,500
+digestive enzymeففي عندنا إنزال أن ربنا حطه فينا
+
+337
+00:34:59,500 --> 00:35:05,040
+دا قضية الـ Alpha-1-Antitrypsin هو أحيانًا بيكون
+
+338
+00:35:05,040 --> 00:35:11,020
+deficient الـdeficiency هذه راح تسبب إنه الإنسان
+
+339
+00:35:11,020 --> 00:35:17,760
+هذا يصير عنده مشكلة في قضية إنه معرّف للاتهابات
+
+340
+00:35:17,760 --> 00:35:23,280
+الرئتين مبتلف بالرئتين ويصير عنده الاشي بكله
+
+341
+00:35:23,280 --> 00:35:29,190
+انفزيمةأو Bronchiectasis أو يعني كلفت الرياتين
+
+342
+00:35:29,190 --> 00:35:36,490
+بنسميه انتزينة فالملاحظ
+
+343
+00:35:36,490 --> 00:35:42,170
+هنا إن طبعاً أي مشاكل في الرياتين من أهم الأسباب
+
+344
+00:35:42,170 --> 00:35:49,990
+مرات كثيرة قضية التدخين التدخين مضر جداً وهنا
+
+345
+00:35:49,990 --> 00:35:58,610
+بحاول أعطيكم تصورفأهمية إنه إذا في إنسان عنده هذا
+
+346
+00:35:58,610 --> 00:36:04,030
+النوع من المشاكل أو يعني هو الأصل حتى لو ما عندهوش
+
+347
+00:36:04,030 --> 00:36:17,490
+الأصل الواحد يشوف يعني قضية إنه أحسن ما يدخلش فالـ
+
+348
+00:36:17,490 --> 00:36:23,850
+Alpha-1-Antitrypsin فيه الـO2الـ Alleles فيه إشي
+
+349
+00:36:23,850 --> 00:36:27,990
+بيقولوله الـ M اللي هو Normal والـ Z اللي هو الـ
+
+350
+00:36:27,990 --> 00:36:35,270
+Abnormal فاللي بيكون عنده ZZ بيكون معرض كتير إنه
+
+351
+00:36:35,270 --> 00:36:45,990
+يصير عنده تلت بريتين وهنا بيبينولهإنه يعني هذه
+
+352
+00:36:45,990 --> 00:36:52,910
+الدراسة بالذات فيها يعني
+
+353
+00:36:52,910 --> 00:36:58,390
+على قضية الوفيات وبالتالي الـSurvival هنا فهنا
+
+354
+00:36:58,390 --> 00:37:03,570
+بيفرجونا إنه لما نكون إنسان Smoker وعنده
+
+355
+00:37:03,570 --> 00:37:10,290
+Limitations على عمر مثلا هنا دخلنا 50% على عمر
+
+356
+00:37:10,290 --> 00:37:14,910
+الأربعين سنة بتوقفطبعًا، بتكون المشاكل قبلها
+
+357
+00:37:14,910 --> 00:37:23,410
+والمشاكل تلريتين بتكون مزمنة وقديمة ومستمرة تكرار
+
+358
+00:37:23,410 --> 00:37:30,610
+التهابات وإدوات تلف تلريتين وجزء من الصورة يعني
+
+359
+00:37:30,610 --> 00:37:35,910
+إذا فيه إشي بدي أكم تتذكرونه لبعدين إن شاء الله
+
+360
+00:37:35,910 --> 00:37:41,730
+لما نصيروا طباء وخصائين وكذاإنه ذات الـ Alpha-1
+
+361
+00:37:41,730 --> 00:37:49,510
+-antitrypsin جيني الأنومالي يكون التلف في الـ
+
+362
+00:37:49,510 --> 00:37:58,430
+lower part of the lungs يعني في مثلا الـ
+
+363
+00:37:58,430 --> 00:38:03,610
+tuberculosis وبتلافى الأجزاء العلوية من الـ lungs
+
+364
+00:38:03,610 --> 00:38:08,350
+هي اللي فيها مشاكل أكتر أما هنا زي ما أنتم شايفين
+
+365
+00:38:08,350 --> 00:38:15,250
+هناهي أشياء غير طبيعية طبعاً الـ «تستكتري» هذه
+
+366
+00:38:15,250 --> 00:38:21,130
+بيقول فيها «hyperinflation» يعني الرياتين مضخمات
+
+367
+00:38:21,130 --> 00:38:26,110
+أو الـ «diaphragm» بدل ما واحد بيشوفه بشكل سليم
+
+368
+00:38:26,110 --> 00:38:34,670
+بيشوفه flattened يعني مش زي قبة مضغوط ومدفوق لتحت
+
+369
+00:38:35,420 --> 00:38:39,640
+فهذه تغيرات وإنه أكتر التغيرات هي في المنطقة
+
+370
+00:38:39,640 --> 00:38:45,900
+السفلية من نظريتيها فهذه حالة اسمها Alpha-1
+
+371
+00:38:45,900 --> 00:38:52,520
+-Antitrypsin Deficiency ويعني
+
+372
+00:38:52,520 --> 00:38:58,720
+بتكون فيها مشكلة في أسئلة سهل الأمور يعني إحنا
+
+373
+00:38:58,720 --> 00:39:04,370
+بدنا هيك الـMajor Things بس يعني اللي بهمنيإنه
+
+374
+00:39:04,370 --> 00:39:12,030
+يعني الواحد لما يشوف مرض
+
+375
+00:39:12,030 --> 00:39:17,990
+بهذا الطريقة وكيف بيأثر على هذا الإشي يتخيل الواحد
+
+376
+00:39:17,990 --> 00:39:24,170
+إنه فيه metabolic pathway متابوليك إنزاين بيصير
+
+377
+00:39:24,170 --> 00:39:29,750
+فيه مشكلة بالأخير بنتج عنه المرض ماشي؟ فيها سؤال
+
+378
+00:39:29,750 --> 00:39:31,370
+إن شاء الله الأمور واضحة
+
+379
+00:39:38,100 --> 00:39:46,440
+الـ تمام إن شاء الله يا دكتور طيب في حالة اسمها
+
+380
+00:39:46,440 --> 00:39:54,920
+Porphyria الـ Porphyria مرض نتيجة
+
+381
+00:39:54,920 --> 00:40:04,100
+خلل الـ metabolism تبع الـ hem part أو الـ
+
+382
+00:40:04,100 --> 00:40:16,800
+hemoglobinإحنا إذا بنتذكر الـ….يعني الـHeme اللي
+
+383
+00:40:16,800 --> 00:40:21,740
+هو الـPyrrole
+
+384
+00:40:21,740 --> 00:40:26,000
+Ring اللي بيكون فيها الحديد اللي بتمسك الـOxygen
+
+385
+00:40:26,000 --> 00:40:27,700
+وجزء من الـHemoglobin
+
+386
+00:40:29,780 --> 00:40:36,220
+بدأت تصنع بالأول بطريقة معينة اللي هي إنه
+
+387
+00:40:36,220 --> 00:40:42,480
+الـGlycine أو سكسينالكوينزين A مع ALA اللي هو
+
+388
+00:40:42,480 --> 00:40:48,900
+Alpha-Hydelta
+
+389
+00:40:48,900 --> 00:40:55,960
+-Delta-Aminolagulinic Acid، ماشي؟ فـSynthetic فهذا
+
+390
+00:40:55,960 --> 00:41:04,420
+الـEnzymeبيعطينا الـ ALA اللي بتحول للـ PDG وبعدين
+
+391
+00:41:04,420 --> 00:41:08,560
+بيعطينا الـ Hydroxy Methyl Biluene بيعطينا الـ
+
+392
+00:41:08,560 --> 00:41:14,000
+Heme وبصير بالعكس بعدين له degradation في قضية
+
+393
+00:41:14,000 --> 00:41:17,360
+ال...
+
+394
+00:41:17,360 --> 00:41:22,460
+بتحول بعدين بالاخير كمان لـBilirubin لما الـ Heme
+
+395
+00:41:22,460 --> 00:41:26,890
+يصير له degradationوتتحول إلى إيش اسمه «بيليردين»
+
+396
+00:41:26,890 --> 00:41:31,130
+وبعدين «بيليروبين» وكذا، هذه كل أمور يعني إن شاء
+
+397
+00:41:31,130 --> 00:41:35,390
+الله أكيد أنتم بالـBiochemistry أخدتوها وعلى الأقل
+
+398
+00:41:35,390 --> 00:41:41,530
+بتعرفوا عنها وبتعرفوا تقريبا شو هي فالـ
+
+399
+00:41:41,530 --> 00:41:44,950
+Intermittent
+
+400
+00:41:44,950 --> 00:41:49,470
+Porphyria هي من الأمراض Acute Intermittent
+
+401
+00:41:49,470 --> 00:41:58,610
+Porphyria عبارة عن يعني إنسانفي لها Variations
+
+402
+00:41:58,610 --> 00:42:04,710
+كثيرة في بعضها بيعطي طفح على الجلد و Skin Rashes
+
+403
+00:42:04,710 --> 00:42:11,810
+إلى طريقة معينة بعضها بيعطيك هو من أسباب الـ Acute
+
+404
+00:42:11,810 --> 00:42:17,150
+Abdomen Medical Acute Abdomen يعني كيف الواحد إذا
+
+405
+00:42:17,150 --> 00:42:23,470
+فجأة بطنه بيصير يوجعه بيصير الواحد يشك في قضية إشي
+
+406
+00:42:23,470 --> 00:42:33,620
+جراحيزايدة قرحة فقبط في دار المعدو الـ12 مثلًا
+
+407
+00:42:33,620 --> 00:42:39,300
+التواء في الأمعاة Volulus مثلًا هذه كلها بنسميها
+
+408
+00:42:39,300 --> 00:42:43,360
+حالات جراحية
+
+409
+00:42:43,360 --> 00:42:51,370
+بينما مرات الوجع البطن ما بكون سببهحالة جراحية
+
+410
+00:42:51,370 --> 00:42:56,750
+بيكون سببه حالة باطنية يعني ما بيداعي لتدخل الجراح
+
+411
+00:42:56,750 --> 00:43:01,410
+فالتالي وعلى عكس مرات إذا الجراح بتدخل بيعمل مشكلة
+
+412
+00:43:01,410 --> 00:43:07,870
+فمثلها مثلًا Diabetic ketoacidosis اللي هي حالة
+
+413
+00:43:07,870 --> 00:43:12,730
+الانتفاع السكر كتير العالي مع نضارة الدم في اللي
+
+414
+00:43:12,730 --> 00:43:17,650
+عندهم نقص كامل في الـ Insulin الـ Type 1 diabetes
+
+415
+00:43:18,230 --> 00:43:22,310
+فهدولة لما يكونوا زي هذا بيكون فيه مشكلة كبيرة
+
+416
+00:43:22,310 --> 00:43:28,390
+Type 1 diabetes منها يكون acute abdomen يعني بيجيك
+
+417
+00:43:28,390 --> 00:43:32,230
+المريض بقلم شديد بالبطن وبيجي يشتك من هذا الموضوع
+
+418
+00:43:32,230 --> 00:43:36,390
+والحالة التانية من حالات أخرى اللي هي acute
+
+419
+00:43:36,390 --> 00:43:41,610
+intermittent porphyria بيصير برضه عنده الإنسان
+
+420
+00:43:41,610 --> 00:43:52,660
+مشكلة في إنه بيصير عنده وجع في البطنالـ… الفكرة
+
+421
+00:43:52,660 --> 00:44:00,380
+بدل واحد يتذكر الـEnzyme يعني على الأقل يعني
+
+422
+00:44:00,380 --> 00:44:06,660
+الـMajor One في قضية المسبب
+
+423
+00:44:06,660 --> 00:44:12,040
+لهذه الحالة ففي الحالة هنا اللي هو الـALA synthase
+
+424
+00:44:12,040 --> 00:44:22,680
+هو الـ… الـ…هو اللي بيعمل العراب هذه ولمّا يكون
+
+425
+00:44:22,680 --> 00:44:27,980
+فيه Enzyme مطلوب لموتابوليزم معينة الاشي اللي قبل
+
+426
+00:44:27,980 --> 00:44:32,400
+الـEnzyme هذا نتيجة خلل الـEnzyme راح يصير في
+
+427
+00:44:32,400 --> 00:44:36,060
+ارتفاع شديد وبالتالي يصير في عندنا accumulation
+
+428
+00:44:36,060 --> 00:44:40,860
+لهذا يعني احنا حكينا عن الفنع الألليل بالـBq هو
+
+429
+00:44:40,860 --> 00:44:48,700
+الـGlycine اللي دخل بالبرفيلفاللي هون اللي حاكينه
+
+430
+00:44:48,700 --> 00:44:52,600
+اللي هي قضية Post-Fertile Neurological Symptoms
+
+431
+00:44:52,600 --> 00:44:59,480
+هذه برضه من المشاكل عراض عصبية بعد البلوغ وهتكون
+
+432
+00:44:59,480 --> 00:45:07,800
+نتيجة مشكلة في الـAlanine الـAmino-Lidulinic Acid
+
+433
+00:45:07,800 --> 00:45:14,180
+Synthetic Defect ويصير هنا Glycine يعني الواحد إنه
+
+434
+00:45:14,180 --> 00:45:19,010
+كمان يعرفالـ Mechanism هذا والـ Enzyme هذا ولوين
+
+435
+00:45:19,010 --> 00:45:24,770
+بيشتغل وعلى شو بيشتغل بيقدر حد يحدد شو هو الـ
+
+436
+00:45:24,770 --> 00:45:31,490
+Amino acid اللي أنا بدي أدور عليه حتى أشوف ذا
+
+437
+00:45:31,490 --> 00:45:37,450
+مرتفع عشان أشخصها أيه الحالة وهنا زي ما حكينا مرات
+
+438
+00:45:37,450 --> 00:45:44,560
+يعني حكينا قبل شوية مثالاللي قبل الـ Alpha-1
+
+439
+00:45:44,560 --> 00:45:52,580
+Antitrypsin Deficiency اللي هو في المثال الـ
+
+440
+00:45:52,580 --> 00:45:55,700
+«هوماسيستينيوريا»
+
+441
+00:45:55,700 --> 00:46:01,280
+ناشي؟ كيف إن الـB6 هنا بيخفف الأمور و بيسهلها هنا
+
+442
+00:46:01,280 --> 00:46:04,640
+بدي أقولكم إن certain drugs and chemicals
+
+443
+00:46:04,640 --> 00:46:09,250
+الـFasting، السيام، بعض الـSteroidsThey
+
+444
+00:46:09,250 --> 00:46:13,770
+precipitate the disease بيصير إنه بيعملوا المشكلة
+
+445
+00:46:13,770 --> 00:46:18,130
+فزي ما كانت المثال اللي قبل إن الـ B6 بيكبّث
+
+446
+00:46:18,130 --> 00:46:23,150
+المشكلة هنا في أحيانًا أشياء بتزيد وفي أنتج كتيرة
+
+447
+00:46:23,150 --> 00:46:35,070
+في مجموعة أمراض يعني اللي هي Familial
+
+448
+00:46:35,070 --> 00:46:41,650
+Hypercholesterolemiaالـ Cholesterol يعني من الـ
+
+449
+00:46:41,650 --> 00:46:45,390
+«موليكولز» الضرورية في بناء الخلية من الأشياء
+
+450
+00:46:45,390 --> 00:46:50,690
+الضرورية للحياة موجودة في الطعام وبنأكلها بس كمان
+
+451
+00:46:50,690 --> 00:46:55,510
+الجسم بيصنعها بيستطيع أنه يصنعها فالـ Metabolism
+
+452
+00:46:55,510 --> 00:47:10,650
+تبعها يعني مهم وأهم يعني مجموعة أمراضنتج عن خلل
+
+453
+00:47:10,650 --> 00:47:16,030
+الكوليسترول هو قضية بالأخير تأثيراته على قضية
+
+454
+00:47:16,030 --> 00:47:20,630
+التصلب الشراين التصلب الشراين من أشع الأمراض
+
+455
+00:47:20,630 --> 00:47:26,770
+الحالية اللي هو مع الـ Process أو الـ Pathogenic
+
+456
+00:47:26,770 --> 00:47:30,870
+Process of Atherosclerosis الـ Atherosclerosis
+
+457
+00:47:30,870 --> 00:47:34,510
+اللي دخل أحيانًا كتير بقضية الـ
+
+458
+00:47:36,480 --> 00:47:40,500
+الضغط والسكري وطبعًا استفاق الدهون وهذا قصد
+
+459
+00:47:40,500 --> 00:47:45,360
+الـMajor Risk Factors زائد فيه تأثيرات Genetic
+
+460
+00:47:45,360 --> 00:47:52,720
+وFamilial وSmoking وMale Sex وغيرهم وغيرهم فالـ
+
+461
+00:47:52,720 --> 00:47:57,360
+Hypercholesterolemiaيعني الأرقام اللي عادة نتكلم
+
+462
+00:47:57,360 --> 00:48:00,440
+عنها طبعاً إلا دخل بالـ Obesity والـ Sedentary
+
+463
+00:48:00,440 --> 00:48:04,880
+Lifestyle والـ Metabolic Syndrome اللي هو نتيجة
+
+464
+00:48:04,880 --> 00:48:10,060
+نمط الحياة الحديث ناس بطلت تمشي، بطلت تبدل حركة
+
+465
+00:48:10,060 --> 00:48:16,720
+ولا نشط عضلاتها وكذا فالـ Cholesterol مهم كثير
+
+466
+00:48:16,720 --> 00:48:21,140
+والـ Cholesterol الـ Major Risk Factor هو الـ
+
+467
+00:48:21,140 --> 00:48:24,500
+Total Cholesterol بس لنتذكر إن الـ Cholesterolاللي
+
+468
+00:48:24,500 --> 00:48:30,300
+هو أنواع اللي هما فيه الـ… الـBad Cholesterol اللي
+
+469
+00:48:30,300 --> 00:48:34,540
+هو Low Density Lipoprotein LDL واللي فيه الـHigh
+
+470
+00:48:34,540 --> 00:48:37,280
+Density Lipoprotein اللي هو الـProtective أو
+
+471
+00:48:37,280 --> 00:48:43,160
+الـكويس فيه كمان VLDL Very Low Density Lipoprotein
+
+472
+00:48:43,160 --> 00:48:49,800
+وفيه الـKylomicrons وفيه الـTriglycerides
+
+473
+00:48:49,800 --> 00:48:56,010
+كنوع تاني من الـLipidsضرورية للحياة وضرورية في
+
+474
+00:48:56,010 --> 00:49:00,290
+الجسم فالواحد
+
+475
+00:49:00,290 --> 00:49:05,590
+يعني ما عرفته لهذه الجوانب ضرورية كثير والواحد بده
+
+476
+00:49:05,590 --> 00:49:12,090
+يتذكر الـcycle of الـcholesterol في الـbody كيف
+
+477
+00:49:12,090 --> 00:49:16,270
+أنه بتبنى انتصاصه في الأمعات، في مناطق معينة إيش
+
+478
+00:49:16,270 --> 00:49:21,670
+اسمه الـkylomicron عبارة عن lipid globulin أو
+
+479
+00:49:21,670 --> 00:49:29,300
+lipidيعني شنطة Lipid موجودة من الـ «تم انتصاصها»
+
+480
+00:49:29,300 --> 00:49:35,780
+في الأمعاق وكيف أن الـLipid حتى ينص الجسم بالذات
+
+481
+00:49:35,780 --> 00:49:39,740
+الـEssential Fatty Acid والـEssential Lipid بدّوا
+
+482
+00:49:39,740 --> 00:49:44,760
+Metabolism مختلف ففي
+
+483
+00:49:44,760 --> 00:49:47,340
+مجموعة ناس بتلاقي عندهم «فميليا»
+
+484
+00:49:47,340 --> 00:49:51,260
+الـHypercholesterolemia بتكون أرقام الـ«كوليسترول»
+
+485
+00:49:51,260 --> 00:49:56,740
+very highطبعاً إحنا الـ Hypercholesterolemia جزء
+
+486
+00:49:56,740 --> 00:50:01,660
+من حتى سريريا ممكن واحد يشوف فيه زي ما إن شاء الله
+
+487
+00:50:01,660 --> 00:50:06,600
+تاخدوا في قضايا الطب السريري فيه اللي هو الـ Arcus
+
+488
+00:50:06,600 --> 00:50:12,340
+Lipidus والـ Xanthlasmas والـ Xanthomas عبارة عن
+
+489
+00:50:12,340 --> 00:50:17,220
+يعني بتشوف على المريض في عينيه حوالين الجسم على
+
+490
+00:50:17,220 --> 00:50:23,640
+الكوع أو على جسمه بتلاقي في عندهترسوبات دهنية،
+
+491
+00:50:23,640 --> 00:50:28,280
+ماشي؟ وهذه اللي دخل أنه يصير عند الواحد أفلسفلورية
+
+492
+00:50:28,280 --> 00:50:36,260
+فالـ Familial Form، ماشي؟ ونتيجة هذا الجزء منه
+
+493
+00:50:36,260 --> 00:50:46,120
+نتيجة فهمنا لـ Metabolism لكيفية الجسم بتعامل مع
+
+494
+00:50:46,120 --> 00:50:51,320
+الـLipids اللي بيمصها من الأمعانأحنا بنصب الأول
+
+495
+00:50:51,320 --> 00:50:55,400
+الـ «كايلو مايكرونز» وبعدين بتتحول لما ناخد منها
+
+496
+00:50:55,400 --> 00:51:00,700
+شوية كوليسترول أكتر بيصير الـDLDL وبعدين بيصير
+
+497
+00:51:00,700 --> 00:51:11,400
+الـLDL في كوليسترول أكتر الـLDL بتم إتصافه مع اللي
+
+498
+00:51:11,400 --> 00:51:17,370
+هو الـLDL ريسبتر على الخلاياوإنه فيه أبوبروتين
+
+499
+00:51:17,370 --> 00:51:23,270
+B100 اللي هو الـCholesterol Easter Core وبعدين
+
+500
+00:51:23,270 --> 00:51:26,710
+بيصير Internalization وبالتالي بنزل نسبة
+
+501
+00:51:26,710 --> 00:51:32,270
+الـCholesterol في الدم فبالنسبة
+
+502
+00:51:32,270 --> 00:51:38,070
+للفميلة الـHypercholesterolemia فيه أكثر من نوع
+
+503
+00:51:38,070 --> 00:51:42,410
+على أقل الـMajor ones أربعة طبعا دولة من
+
+504
+00:51:42,410 --> 00:51:46,860
+الـEuropean descentفي مثلًا الـItalian ومدينة
+
+505
+00:51:46,860 --> 00:51:51,100
+الـEastern من كيف بيشي ده في الصينيين، اشي في
+
+506
+00:51:51,100 --> 00:51:55,920
+السود، اشي في كده ودول الأنواع، اشي اللي دخل
+
+507
+00:51:55,920 --> 00:52:03,820
+الـLDL-Receptor أو الـApoprotein B100 أو الـARH
+
+508
+00:52:03,820 --> 00:52:10,920
+-Adapter Protein أو الـPCSK9-Protease بيصير يعني
+
+509
+00:52:10,920 --> 00:52:15,030
+loss of function أو gain of functionوفي الغالب هما
+
+510
+00:52:15,030 --> 00:52:18,310
+autosomal dominant إلا إذا بعض فيه أشياء autosomal
+
+511
+00:52:18,310 --> 00:52:25,350
+resistant الطبيعي يعني
+
+512
+00:52:25,350 --> 00:52:30,110
+إحنا الـ optimal cholesterol level بالmilligram
+
+513
+00:52:30,110 --> 00:52:35,450
+per deciliter الطبيعي لإنسان ماعنديهوش مشكلة ويعني
+
+514
+00:52:35,450 --> 00:52:39,190
+مش مريض بعيشي تاني مش خائفين من قضية
+
+515
+00:52:39,190 --> 00:52:44,460
+الـAtherosclerosis نقبل لحد الميتينإذا كان عند
+
+516
+00:52:44,460 --> 00:52:47,420
+الواحد one two risk factors الـ optimal يكون تحت
+
+517
+00:52:47,420 --> 00:52:53,180
+الـ 160 إذا فيه عنده مشكلة وانده صار تصلف شرايين
+
+518
+00:52:53,180 --> 00:52:57,500
+بدنا هي تحت الـ 130 فالفميلة الـ
+
+519
+00:52:57,500 --> 00:53:03,160
+hypercholesterolemia الـ homozygous one في الـ LDL
+
+520
+00:53:03,160 --> 00:53:09,600
+receptor عادةً بيكون حوالي 700 بينما إذا
+
+521
+00:53:09,600 --> 00:53:14,910
+heterozygous وصل 350الـ Normal Adult حاطينه لحد
+
+522
+00:53:14,910 --> 00:53:20,510
+الـ 120 يعني يمكن دراسات أجدد وكل مكان أنزل أحسن
+
+523
+00:53:20,510 --> 00:53:26,950
+ففي عائلات بتلاقي و بتلاقي عندهم مشكلة لأن الـ
+
+524
+00:53:26,950 --> 00:53:30,890
+cholesterol very high وبالتالي مع ال other risk
+
+525
+00:53:30,890 --> 00:53:35,450
+factors بتخلي ال atherosclerosis يصير بشكل سريع
+
+526
+00:53:35,450 --> 00:53:42,290
+إذا بتلاقي عيلة فيها جنفات
+
+527
+00:53:43,240 --> 00:53:49,960
+في القلب، جلطات على الدماغ، جلطات وتصلب شرايين
+
+528
+00:53:49,960 --> 00:53:54,640
+وحطوا شبكات ومشاكل زي هيك في جزء منه التدخين
+
+529
+00:53:54,640 --> 00:53:58,820
+والضغط السكري صحيح بس عامل مهم كتير الـ
+
+530
+00:53:58,820 --> 00:54:03,640
+Hypercholesterolemia بالذات Daphamelial وفيه الآن
+
+531
+00:54:03,640 --> 00:54:09,680
+يعني دراسات على قضية الـ Mutations اللي بتسببها
+
+532
+00:54:09,680 --> 00:54:16,650
+الـ إمتى بنفكر في الموضوع هذا؟جزء منه لما يكون الـ
+
+533
+00:54:16,650 --> 00:54:20,990
+cholesterol very high يعني زي لما تشوف رقم زي هاتف
+
+534
+00:54:20,990 --> 00:54:27,370
+700 وبعدين بسأل عن أهل المريض وأقاربه وشو أوضعهم،
+
+535
+00:54:27,370 --> 00:54:32,490
+إذا بلاقي إشي زي هاتف، بالغالب هذه المشكلة، فهنا
+
+536
+00:54:32,490 --> 00:54:38,950
+هاي مثال على level حكينا إنه الإنسان الطبيعي يعني
+
+537
+00:54:38,950 --> 00:54:45,820
+هو أنا حاطي 160، 120، 180كيف أن الـ… الـ… الـ…
+
+538
+00:54:45,820 --> 00:54:50,520
+الـHeterozygous بالأربعميات الـHomozygous
+
+539
+00:54:50,520 --> 00:54:57,020
+بالسبعمية يعني مع أن يعني حتى في ملاحظة للهدول
+
+540
+00:54:57,020 --> 00:55:03,180
+الـHyperlipidemia لما يكون لما
+
+541
+00:55:03,180 --> 00:55:11,140
+يكون الـLevel very very very high حتى يعني أحياناً
+
+542
+00:55:11,140 --> 00:55:15,850
+بنلاقي الظاهرة هذهوأحنا نسحب الدم بتلاقيك وانت
+
+543
+00:55:15,850 --> 00:55:24,370
+تسحب دم المريض بتلاقي الدم مش لونه طبيعي عضياء
+
+544
+00:55:24,370 --> 00:55:29,630
+كأنه حليبي صار يعني فعلا بتلاقي فيه دهون موجود
+
+545
+00:55:29,630 --> 00:55:37,310
+ازيادي وبتكون نتيجة مشكلة هذا الموضوع فالـ Low
+
+546
+00:55:37,310 --> 00:55:41,010
+-Density Lipoprotein له
+
+547
+00:55:43,510 --> 00:55:49,150
+Different forms of mutations والموضوع اللي دخل
+
+548
+00:55:49,150 --> 00:55:54,310
+بالـ Familial hypercholesterolemia وإلها أنواع
+
+549
+00:55:54,310 --> 00:56:04,350
+وأشكال وكذا بد الواحد يكون يعرف عنها الأنواع
+
+550
+00:56:04,350 --> 00:56:11,130
+المختلفة يعني بشكل عام هذا المشكلة
+
+551
+00:56:12,860 --> 00:56:19,060
+في حالة أخرى اسمها «cystic fibrosis» «cystic
+
+552
+00:56:19,060 --> 00:56:30,440
+fibrosis» يعني برضه اللي هو في الغالب «autosomal
+
+553
+00:56:30,440 --> 00:56:33,640
+recessive»
+
+554
+00:56:33,640 --> 00:56:39,440
+«cystic fibrosis» حالة
+
+555
+00:56:40,800 --> 00:56:47,820
+هي من أسباب أو قريبة من الـ تشتركتي تقريبًا مع
+
+556
+00:56:47,820 --> 00:56:52,700
+حكينا عن موضوع الـ Alpha-1-Antithepsin Deficiency
+
+557
+00:56:52,700 --> 00:56:58,080
+بتسبب برضه مشكلة بالنسبة للريعتين مبكرة يعني اللي
+
+558
+00:56:58,080 --> 00:57:04,400
+بيكون إنسان أو طفل أو عائلة عندها أفراد بتصير
+
+559
+00:57:04,400 --> 00:57:10,370
+عندهم تكرار في حدوث انتهاب الريعتينبكون مشكلة في
+
+560
+00:57:10,370 --> 00:57:18,430
+قضية الـ… بيكون قضية أحيانًا الـcystic fibrosis
+
+561
+00:57:18,430 --> 00:57:25,930
+الـ… الـcystic fibrosis بتعمل مشكلة في الرئتين
+
+562
+00:57:25,930 --> 00:57:32,270
+نتيجة تكرار الجهد وممكن تعطينا مشكلة يعني تخراب في
+
+563
+00:57:32,270 --> 00:57:38,050
+الرئتين وبتعمل مشكلة إنهحتى بالنسبة لو وظيفة
+
+564
+00:57:38,050 --> 00:57:42,390
+البنكرياس بيصير فيها مشكلة لو بيصير malabsorption
+
+565
+00:57:42,390 --> 00:57:49,450
+بيصير مشاكل سوء هضم growth retardation بيصير مشكلة
+
+566
+00:57:49,450 --> 00:57:59,990
+فيها لما درسوا الموضوع فيه very important يعني
+
+567
+00:57:59,990 --> 00:58:05,850
+بالأخير geneاللي هو سميناها بعدين «cystic fibrosis
+
+568
+00:58:05,850 --> 00:58:11,610
+transporter receptor gene» اللي هو «CFTR» هذا
+
+569
+00:58:11,610 --> 00:58:21,830
+عبارة عن موليكيول كبير وظيفته إنه بيعمل exchange
+
+570
+00:58:21,830 --> 00:58:27,930
+between الصوديوم والبوتاسيوم والكالسيوم حوالين على
+
+571
+00:58:27,930 --> 00:58:34,150
+الـ cell wall يعني هواللي بيكون بالأخير بتحكم في
+
+572
+00:58:34,150 --> 00:58:41,650
+قضية ادخال وإخراج الـ… هدولة الـ… الـIons
+
+573
+00:58:41,650 --> 00:58:48,490
+الـPositive Ions من الـCell فالـ…
+
+574
+00:58:48,490 --> 00:58:54,350
+زي ما هم رسمينكم هنا، الـCFTR وحطينا Capital،
+
+575
+00:58:54,350 --> 00:59:01,450
+الـCapital هي للـGene، ناشي؟ فعطينا الـCFTRبالأول
+
+576
+00:59:01,450 --> 00:59:07,550
+الـ In-between اللي هو الـ RNA Messenger RNA
+
+577
+00:59:07,550 --> 00:59:18,350
+وبعدين بيعطينا البروتين الـ CFTR جين له Exons فالـ
+
+578
+00:59:18,350 --> 00:59:27,270
+Exons 23 Exons ماشي الـ Exons هم اللي بدخلوا
+
+579
+00:59:27,270 --> 00:59:31,780
+التركيبالبروتين والـ introns in between are
+
+580
+00:59:31,780 --> 00:59:38,220
+removed at the stage of the messenger RNA البروتين
+
+581
+00:59:38,220 --> 00:59:48,220
+الأخير هو Complex يعني هو بوابة لتنقل
+
+582
+00:59:48,220 --> 01:00:00,470
+الـ ions in the cell membrane فبيجي تركيبه هيفالـ
+
+583
+01:00:00,470 --> 01:00:05,830
+Cystic Fibrosis يعني إيه دخل بالـ Lungs إيه دخل
+
+584
+01:00:05,830 --> 01:00:11,670
+بالـ Pancreas و بالـ GI الفحص السريري عندنا بتذكر
+
+585
+01:00:11,670 --> 01:00:17,490
+أستاذ إيه اللي كنا في الكويت كان يقول شخصة Cystic
+
+586
+01:00:17,490 --> 01:00:24,250
+Fibrosis لأنه أم الطفل مولود حديد بتقول يا دكتور
+
+587
+01:00:24,250 --> 01:00:33,300
+عرق الطفل مالح كتيرشايف إن ملوحته زايد كثير كانت
+
+588
+01:00:33,300 --> 01:00:38,780
+اللي لما إنها بيسموه chloride sweat test يعني
+
+589
+01:00:38,780 --> 01:00:44,580
+إبارة عن test إنه بيخلوا بيبقوا يعني بيحطوا زي
+
+590
+01:00:44,580 --> 01:00:49,840
+منشف على منشف غير منفذ على الطفل و بيخلوه يقرأ
+
+591
+01:00:51,090 --> 01:00:55,750
+وبيجمعوا العرق تبعه بيشوفوا مستوى الملح فيه وهذا
+
+592
+01:00:55,750 --> 01:01:01,690
+بيسموه chloride sweat test أو sweat chloride test
+
+593
+01:01:01,690 --> 01:01:06,410
+إذا أكثر من ستين أقل من ستين قولوا أرقام وبنعرف
+
+594
+01:01:06,410 --> 01:01:16,420
+عنها فالـعبارة عن Complex Protein اللي دخل بالـ
+
+595
+01:01:16,420 --> 01:01:24,840
+Cell Membrane بالأخير بتحكم بإدخال وإخراج الـ Ions
+
+596
+01:01:24,840 --> 01:01:29,540
+from and into the cell فاللي دخل بالـ Secretions
+
+597
+01:01:29,540 --> 01:01:34,520
+واللي دخل في وظائف الرئتين والبكريات فهنا في محالة
+
+598
+01:01:34,520 --> 01:01:40,910
+اسمها Cystic Fibrosis وبيحاولوا يساعدوهموبحاولوا
+
+599
+01:01:40,910 --> 01:01:47,530
+يعني يدرسوا الموضوع هذا في حالات أخرى زي مثلًا الـ
+
+600
+01:01:47,530 --> 01:01:51,550
+Duchene Muscular Dystrophy الـ Duchene عبارة عن
+
+601
+01:01:51,550 --> 01:02:00,430
+مرض في تركيب من العضلات بيكون حجم العضلات كبير بس
+
+602
+01:02:00,430 --> 01:02:05,090
+ضعيف يعني بتحسه يسمونه pseudo-hypertrophy pseudo
+
+603
+01:02:05,090 --> 01:02:11,950
+يعني كابل يعني بيكونفي ضعف العضلات ويمكن تكلمنا
+
+604
+01:02:11,950 --> 01:02:17,410
+مرة من قبل عنه تبارعًا الـ protein مطلوب للـ
+
+605
+01:02:17,410 --> 01:02:24,670
+action of the muscles واسمه دول الأمراض
+
+606
+01:02:28,410 --> 01:02:32,630
+يعني الـGenetic وهكون إلها أكتر من نوع وفيه إشي
+
+607
+01:02:32,630 --> 01:02:37,870
+اسمه «فكر» «Muscular Dystrophy» أخف وبيبدأ بشكل
+
+608
+01:02:37,870 --> 01:02:44,630
+متأخر عن الـClassical «دوشين» اتكلمنا عنهم وقلناوا
+
+609
+01:02:44,630 --> 01:02:49,130
+إله فيه مشاكل
+
+610
+01:02:49,130 --> 01:02:55,790
+وفيه أكتر من نوع قضية الـ«دوشين»في الـ
+
+611
+01:02:55,790 --> 01:03:00,390
+Achondroplasia أو أستوجينيسيا انبرفكتا برضه من
+
+612
+01:03:00,390 --> 01:03:09,730
+الأمراض الأخرى في العبام وأستوجينيسيا
+
+613
+01:03:09,730 --> 01:03:14,370
+انبرفكتا اللي هو فيه مشكلة الـ Type 1 collagen
+
+614
+01:03:14,370 --> 01:03:21,610
+genes برضه يعني هترجعلكم مرة صورة عنها هتذكرها
+
+615
+01:03:21,610 --> 01:03:28,710
+لأنهلما كنت في التدريب السريري وانا طالب كان عندنا
+
+616
+01:03:28,710 --> 01:03:33,050
+طفل أو مش طفل هي امرأة كبيرة بالعمر كان عمرها
+
+617
+01:03:33,050 --> 01:03:38,890
+حوالي يعني تلاتين سنة بس على wheelchair حجمها قدر
+
+618
+01:03:38,890 --> 01:03:44,530
+طفل عمره سنة، سنتين، قزم كثير وفيه كسور في الإباعم
+
+619
+01:03:44,530 --> 01:03:50,110
+وفيه كسور فيه هشاشة وفيه مشكلة والـSclera are blue
+
+620
+01:03:51,570 --> 01:03:56,450
+حوالين المنطقة الملونة في العين بيزرقاق وهي
+
+621
+01:03:56,450 --> 01:04:00,590
+Osteogenesis Imperfecta واللي هي أكتر من نوعها من
+
+622
+01:04:00,590 --> 01:04:06,450
+الأمراض بالنسبة للـ College بدناهاش تفاصيل الأمور
+
+623
+01:04:06,450 --> 01:04:13,330
+هذه وفيها مشاكل كتيرة المجموعة
+
+624
+01:04:13,330 --> 01:04:19,750
+الأخيرة من الأمراض هم أيضًا من الأمراض اللي دخل
+
+625
+01:04:19,750 --> 01:04:25,030
+بالجهاز العصبياللي هما Alzheimer Disease الألزايمر
+
+626
+01:04:25,030 --> 01:04:30,710
+هو حالة نتيجة الـ…
+
+627
+01:04:30,710 --> 01:04:34,970
+الـ… الـ… يعني بدنا نسميه «pre-senile dementia» هي
+
+628
+01:04:34,970 --> 01:04:42,170
+حالة الخرف المبكر كيف إن الإنسان يصير يخرف أو يعني
+
+629
+01:04:42,170 --> 01:04:47,350
+عنده خرف اللي هو تناقص في قدراته العقلية في ذكاءه،
+
+630
+01:04:47,350 --> 01:04:55,360
+في ذاكرته، فيالتعامل هو فيه بتأثر صراحة يعني معه
+
+631
+01:04:55,360 --> 01:05:01,760
+ازدياد عمار الناس تصبح أي ظاهرة أو مشكلة كبيرة
+
+632
+01:05:01,760 --> 01:05:08,220
+بيصير يعني ذا كبار بالعمر يعني يعني من أهم الأمراض
+
+633
+01:05:08,220 --> 01:05:14,740
+الأشياء اللي بتخوف وبيصير الواحد يعني عنده متكاسب
+
+634
+01:05:14,740 --> 01:05:22,700
+بالنسبة لقدرات العقليةفالفكرة إنه الإنسان يعني ضعف
+
+635
+01:05:22,700 --> 01:05:28,500
+شديد في القدرات العقلية متوقع على عمره كان فوق
+
+636
+01:05:28,500 --> 01:05:34,940
+الـ85، 90، بعد هيك متوقع أن يكون فيه مشكلة في
+
+637
+01:05:34,940 --> 01:05:40,240
+القدرات العقلية بالإضافة لقدرات الجسمانية العضلية
+
+638
+01:05:40,240 --> 01:05:47,410
+والطول والحركة وكذا، بتصير فيه مشاكلأما لما تصير
+
+639
+01:05:47,410 --> 01:05:52,510
+هذه الأمور بشكل مبكر على سن الأربعين أو الخمسين أو
+
+640
+01:05:52,510 --> 01:05:57,690
+الستين هذا بنسميه «الزايمرد» وتكون «resinyl
+
+641
+01:05:57,690 --> 01:06:08,990
+dementia» لاحظنا أن أحيانًا هذه بتكون
+
+642
+01:06:08,990 --> 01:06:19,580
+عبارة عن كثير منهافيه ترسُبات من عبارة عن الـ
+
+643
+01:06:19,580 --> 01:06:25,420
+«بروتينز» زي الـ Amyloid وبتكون ترسُبات في الدماغ
+
+644
+01:06:25,420 --> 01:06:32,200
+وفيه أشياء بيكون مش طبيعية فلقينا بعدين فيه
+
+645
+01:06:32,200 --> 01:06:37,020
+certain genetic mutations وهي بعضها autosomal
+
+646
+01:06:37,020 --> 01:06:41,280
+dominant وفيه أشياء بتكون الـinheritance تبعتها
+
+647
+01:06:41,280 --> 01:06:47,940
+مختلفةهنا يعني بيعطوا أنثى على إيش يسموه Beta
+
+648
+01:06:47,940 --> 01:06:52,580
+-amyloid precursor للبروتين هذه في فميليا
+
+649
+01:06:52,580 --> 01:06:57,240
+الـAlzheimer disease وبيكون نتيجة Mutations في
+
+650
+01:06:57,240 --> 01:07:02,200
+Enzymes معينين اللي دخل بالـMetabolism حيث إنه
+
+651
+01:07:02,200 --> 01:07:05,240
+بيصير لنا Precipitation للـamyloid هذا بالدمعة
+
+652
+01:07:05,240 --> 01:07:09,800
+وبتعطينا اللي
+
+653
+01:07:09,800 --> 01:07:12,280
+هو الـAlzheimer
+
+654
+01:07:14,990 --> 01:07:19,310
+Apolipoprotein E Polymorphism برضه هذا واحد من الـ
+
+655
+01:07:19,310 --> 01:07:24,550
+mechanisms للـ Familial Alzheimer Disease وفي
+
+656
+01:07:24,550 --> 01:07:31,050
+أنواع كثيرة الـ mitochondrial DNA فيه لأمراض برضه
+
+657
+01:07:31,050 --> 01:07:38,550
+كثيرة ذكروا الـ mitochondrial أنه حسب ممكن
+
+658
+01:07:38,550 --> 01:07:44,360
+dominant ممكن recessive بس الفكرة أنهبتم نقله من
+
+659
+01:07:44,360 --> 01:07:50,840
+خلال الأم فقط يعني لو ذكر مصاب ماشي و عنده إصابة
+
+660
+01:07:50,840 --> 01:07:55,200
+بس ما بعطي ولاده و بناته إنما الأنثى فقط هي اللي
+
+661
+01:07:55,200 --> 01:07:59,260
+بتعطي بسبب إن الـ mitochondria يتم نقل عن طريق
+
+662
+01:07:59,260 --> 01:08:07,240
+الأوفا فقط فاللي سموه اللي
+
+663
+01:08:07,240 --> 01:08:13,940
+هو الـ lipare retinopathy أي شيء دخل بالعيونفي
+
+664
+01:08:13,940 --> 01:08:23,760
+إبنيء الـ Lactic Acidosis على Encephalopathy على
+
+665
+01:08:23,760 --> 01:08:28,860
+Stroke Life Picture يعني الإنسان شكله بيجي جلطة
+
+666
+01:08:28,860 --> 01:08:33,580
+ويقول فيه مشكلة Serendomyopathy
+
+667
+01:08:37,850 --> 01:08:41,490
+يعني فيه بتعطي مشاكل كثيرة نتيجة الـMitochondrial
+
+668
+01:08:41,490 --> 01:08:47,710
+Disease الـI لها أنواع كثيرة وزي ما انتوا شايفين
+
+669
+01:08:47,710 --> 01:08:51,810
+يعني أهم شي فيها اللي هي إنه الـInheritance
+
+670
+01:08:51,810 --> 01:09:01,170
+maternal فقط ما بيقول فيه شو اسمه يكون دخل بالنسبة
+
+671
+01:09:01,170 --> 01:09:07,420
+للأب يعطي الحالة هذا يعني مش غلط دلواحد بيشوفيعني
+
+672
+01:09:07,420 --> 01:09:12,480
+إنسان عنده بالذات ضعف عضلات اشتلال في العصاب بشكل
+
+673
+01:09:12,480 --> 01:09:19,980
+يعني ليش أقول مميز أو غريب بالذات لما يكون فيه
+
+674
+01:09:19,980 --> 01:09:30,140
+تاريخ عالي يجب أن يكون أحد يتذكر هذه الأشياء فيه
+
+675
+01:09:30,140 --> 01:09:38,470
+كمان أمراض وحالات ثانية يكون الـ Mechanismقضية مش
+
+676
+01:09:38,470 --> 01:09:41,610
+في الـ Coding DNA يعني احنا كثير من الأشياء اللي
+
+677
+01:09:41,610 --> 01:09:46,570
+اتكلمنا عنها عبارة عن أمثلة عن أنه الـ Protein
+
+678
+01:09:46,570 --> 01:09:49,930
+بيكون فيه مشكلة نتيجة أنه الـ Gene فيه مشكلة
+
+679
+01:09:49,930 --> 01:10:01,770
+أحيانًا في أمراض وحالات بيكون المشكلة في الـ يعني
+
+680
+01:10:01,770 --> 01:10:12,170
+بعد ما تصير قضيةالـ يعني الحالات هنا بتكون repeat
+
+681
+01:10:12,170 --> 01:10:19,270
+اللي هو Tri-nucleotide repeat disease اللي هي إنه
+
+682
+01:10:19,270 --> 01:10:24,990
+بيصير خلل على مستوى أوضح على مستوى الـRNA ففيه
+
+683
+01:10:24,990 --> 01:10:27,650
+Myotonic Dystrophy وHuntington disease
+
+684
+01:10:27,650 --> 01:10:33,310
+وFrederick's ataxia وFragileالـ X-Syndrome العادية
+
+685
+01:10:33,310 --> 01:10:40,010
+والـ Tremor Attack Syndrom يعني عبارة عن ملاحظة أن
+
+686
+01:10:40,010 --> 01:10:44,190
+أهم شيء تقريبًا العصاب هي اللي لدينا مشكلة فيها
+
+687
+01:10:44,190 --> 01:10:49,310
+والـ Huntington's Disease مرعب يعني للإنسان
+
+688
+01:10:49,310 --> 01:10:52,950
+ولعائلة بتاعته والله يحمينا مش من الأشياء اللي
+
+689
+01:10:52,950 --> 01:11:01,030
+كتير لدينا منها مشاكل أتأمل أن أكون يعني غطيتبشكل
+
+690
+01:11:01,030 --> 01:11:10,790
+يعني بأعطيكم هيك بعض المعلومات بشكل مفيد لإيش
+
+691
+01:11:10,790 --> 01:11:19,070
+أمراض من هذه الناحية وإذا حد عنده أسئلة يسأل
+
+692
+01:11:19,070 --> 01:11:26,470
+أنا يعني بعد قليل عند التزام ثاني، محاضرة ثانية
+
+693
+01:11:27,020 --> 01:11:34,080
+فهذا الـ Spectrum أو هذه الأمثلة
+
+694
+01:11:34,080 --> 01:11:40,460
+اللي بيحاولوا يفرجوكم فيها بدايةً إيش الخلق في
+
+695
+01:11:40,460 --> 01:11:45,380
+الجيل، على إيش المأثر، وفي الأخير كيف بعطينا المرض
+
+696
+01:11:45,380 --> 01:11:48,960
+لأن
+
+697
+01:11:48,960 --> 01:11:57,640
+الـ «هيس» قال أنا بتوقع السؤال راح يكون علىمطلوب،
+
+698
+01:11:57,640 --> 01:12:04,080
+مش مطلوب، مش عارف إيه، إيش، كده يعني لما الواحد
+
+699
+01:12:04,080 --> 01:12:11,960
+يكون على اطلاع على كيف هذه الحالات بتصير وشو الـ
+
+700
+01:12:11,960 --> 01:12:18,260
+Mechanism تبعتها وكيف بتكون بيكون الواحد إن شاء
+
+701
+01:12:18,260 --> 01:12:21,960
+الله طبيب ودكتور أحسن فيه أسئلة؟
+
+702
+01:12:24,620 --> 01:12:31,100
+كأنني شُفت إنه فيه الـ «تشات» أو الـ
+
+703
+01:12:31,100 --> 01:12:35,680
+«تشات» أنا
+
+704
+01:12:35,680 --> 01:12:44,960
+اللي بيهمني يعني هي أمور مش للحِطب بالذات الـ
+
+705
+01:12:44,960 --> 01:12:49,200
+«metabolic steps» أو كده بقدر ما إنه مثلًا نوعية
+
+706
+01:12:49,200 --> 01:12:53,160
+الـEnzymes اللي إيش هي، على أي شي بتشتغل، ما هو
+
+707
+01:12:53,160 --> 01:12:59,800
+اسم الـ«إنزايم»بقولّك على إيش بيشتغل يعني في نوع
+
+708
+01:12:59,800 --> 01:13:04,340
+الأنانين مثلًا «هيدروكسيلز» ولا «سينتيز» ولا إشي
+
+709
+01:13:04,340 --> 01:13:13,320
+يعني إيه دخل بالأماكن
+
+710
+01:13:13,320 --> 01:13:19,560
+التفرات؟ لأ، ما فيش حد ممكن يحفظ أماكن التفرات زي
+
+711
+01:13:19,560 --> 01:13:23,800
+ما حكيت في أمثلة كثيرة عدد التفرات كبير جدًا، هائل
+
+712
+01:13:23,800 --> 01:13:27,820
+جدًاالأخير كلهم بيخربوا نفس الـ Enzyme بطرق مختلفة
+
+713
+01:13:27,820 --> 01:13:32,780
+أو نفس البروتين بيخربوه بطرق مختلفة الـ Alzheimer
+
+714
+01:13:32,780 --> 01:13:39,300
+له ثمن كبير وممكن يكون مميت طبعاً يعني نفسه نفسه
+
+715
+01:13:39,300 --> 01:13:47,340
+الإنسان بعد يعني هو الإنسان فقط كجسم لأ يعني القلب
+
+716
+01:13:47,340 --> 01:13:52,120
+والريعتين بيشتغل جزء من الدماغ يعني بالـ Brain
+
+717
+01:13:52,120 --> 01:13:59,090
+Stem بتحكم بالأشياءاللي هي الضرورية، وهدولة بتبقى
+
+718
+01:13:59,090 --> 01:14:03,070
+شغالة، ما بتتأثر أما الـAlzheimer بيأثر على
+
+719
+01:14:03,070 --> 01:14:09,130
+إنسانية الإنسان على دماغه من ناحية الـHigher
+
+720
+01:14:09,130 --> 01:14:13,650
+Mental Functions الشخصية،
+
+721
+01:14:13,650 --> 01:14:24,760
+اللغة، الذكاء، التعامل الاجتماعي، كذاالإنسان يعني
+
+722
+01:14:24,760 --> 01:14:32,140
+بتمنى وبرغب دايما انه يكون مستقل يكون انه هو يعني
+
+723
+01:14:32,140 --> 01:14:41,420
+هو مستقل وهو يقدر يعمل يعيش بحياته أنا مضطر هسة
+
+724
+01:14:41,420 --> 01:14:47,820
+أترك ماشي و بنكمل يوم الأربعاء عشان أقول للعالمين
+
+725
+01:14:47,820 --> 01:14:54,600
+يعطيك ألف عفو يا دكتور أهلا و سهلانعم لأ هو خارج
+
+726
+01:14:54,600 --> 01:14:59,560
+المحاضرة خلاص مش مشكلة خير الله يعطيك ألف عفو يا
+
+727
+01:14:59,560 --> 01:15:03,840
+دكتور الله يحييكم أهلا وسهلا نشوفكم على خير ان شاء
+
+728
+01:15:03,840 --> 01:15:04,040
+الله
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/uzpVhimo_X4_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/uzpVhimo_X4_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..2ceccb7063342e35f40e0a98f4f22a9c8d3b0bbb
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/uzpVhimo_X4_raw.json
@@ -0,0 +1 @@
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"text": "اسمها regression ماشي اللي هو يعني التراجع يعني احنا بالأطفال أنا مش طبيب أطفال بس بالأطفال الـ milestones تبعات الطفل يعني أمتى عند الولادة أو أول الولادة و بعدها على أي مدة و هاي الـ 70 أطفال مسؤولين عنها و لازم يحرك أمتى الطفل بيقدر يقلب على بطنه", "tokens": [32277, 2304, 11296, 24590, 3714, 33599, 1829, 13672, 1829, 31439, 37495, 22653, 16712, 2288, 26108, 3615, 37495, 22653, 1975, 5016, 8315, 20666, 10721, 9566, 5172, 6027, 41850, 37893, 23032, 21292, 3555, 5551, 9566, 5172, 6027, 4724, 3794, 20666, 10721, 9566, 5172, 6027, 2423, 39184, 42038, 6055, 3555, 3615, 9307, 41950, 5172, 1211, 37495, 22653, 5551, 2304, 49975, 43242, 2423, 12610, 18513, 3660, 34051, 5551, 12610, 2423, 12610, 18513, 3660, 4032, 39182, 11296, 15844, 36632, 3714, 41891, 4032, 8032, 47302, 2423, 39184, 5285, 5551, 9566, 5172, 6027, 47524, 33604, 12610, 9957, 18871, 11296, 4032, 5296, 31377, 2304, 7251, 5016, 31747, 5551, 2304, 49975, 41950, 5172, 1211, 4724, 1829, 28543, 2288, 7251, 4587, 46152, 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4561.37, "end": 4562.03, "word": " كبير", "probability": 0.9363606770833334}, {"start": 4562.03, "end": 4563.43, "word": " «Giant", "probability": 0.88134765625}, {"start": 4563.43, "end": 4564.23, "word": " Gonads»", "probability": 0.7740885416666666}, {"start": 4564.23, "end": 4564.57, "word": " الـ", "probability": 0.648681640625}, {"start": 4564.57, "end": 4565.31, "word": " «Macro", "probability": 0.83935546875}, {"start": 4565.31, "end": 4566.89, "word": "-Orchidism»", "probability": 0.8515218098958334}, {"start": 4566.89, "end": 4567.21, "word": " يعني", "probability": 0.83154296875}, {"start": 4567.21, "end": 4568.13, "word": " التستيكلز", "probability": 0.666357421875}, {"start": 4568.13, "end": 4568.91, "word": " كبار", "probability": 0.98876953125}, {"start": 4568.91, "end": 4570.21, "word": " فهنا", "probability": 0.5518391927083334}, {"start": 4570.21, "end": 4573.25, "word": " «CGG»", "probability": 0.90869140625}, {"start": 4573.25, "end": 4574.93, "word": " «Myotonia»", "probability": 0.89853515625}, {"start": 4574.93, "end": 4575.29, "word": " الـ", "probability": 0.6866455078125}, {"start": 4575.29, "end": 4576.41, "word": " «Cataract»", "probability": 0.86005859375}, {"start": 4576.41, "end": 4577.23, "word": " «Tope»", "probability": 0.55926513671875}, {"start": 4577.23, "end": 4577.67, "word": " يعني", "probability": 0.9287109375}, {"start": 4577.67, "end": 4578.41, "word": " الـ", "probability": 0.6063232421875}, {"start": 4578.41, "end": 4578.85, "word": " «Tope»", "probability": 0.9542236328125}, {"start": 4578.85, "end": 4579.19, "word": " أظن", "probability": 0.92578125}, {"start": 4579.19, "end": 4580.09, "word": " دكرتها", "probability": 0.6439208984375}, {"start": 4580.09, "end": 4580.41, "word": " الآن", "probability": 0.5518798828125}], "temperature": 1.0}, {"id": 164, "seek": 460766, "start": 4581.0, "end": 4607.66, "text": "اللي هي قطعة الشعر المستعار اللي يبقى عنده صلع أو مستحيل منه مثل أبيه بيجيب ذات زلام مرات بيخطوها وقنادة الـ Atrophy الـ Huntington Disease الـ Caudate Nucleus عيب الـ Brain مافيش فيها Acetylcholine ولا الجابا", "tokens": [6027, 20292, 39896, 12174, 9566, 27884, 25124, 3615, 2288, 9673, 14851, 3615, 9640, 13672, 1829, 7251, 3555, 4587, 7578, 43242, 3224, 20328, 1211, 3615, 34051, 3714, 14851, 5016, 26895, 9154, 3224, 50113, 1211, 5551, 21292, 3224, 4724, 1829, 7435, 1829, 3555, 29910, 9307, 30767, 37440, 3714, 2288, 9307, 4724, 1829, 9778, 9566, 2407, 11296, 4032, 4587, 8315, 3215, 3660, 2423, 39184, 1711, 40826, 2423, 39184, 44793, 1756, 35360, 2423, 39184, 383, 3751, 473, 426, 1311, 306, 301, 6225, 1829, 3555, 2423, 39184, 29783, 19446, 41185, 8592, 8978, 11296, 5097, 2210, 75, 339, 18773, 49429, 25724, 16758, 995], "avg_logprob": -0.31090560312173804, "compression_ratio": 1.4469026548672566, "no_speech_prob": 1.1324882507324219e-06, "words": [{"start": 4581.0, "end": 4581.36, "word": "اللي", "probability": 0.8779296875}, {"start": 4581.36, "end": 4581.9, "word": " هي", "probability": 0.861328125}, {"start": 4581.9, "end": 4582.46, "word": " قطعة", "probability": 0.83642578125}, {"start": 4582.46, "end": 4582.92, "word": " الشعر", "probability": 0.9814453125}, {"start": 4582.92, "end": 4583.72, "word": " المستعار", "probability": 0.8160400390625}, {"start": 4583.72, "end": 4584.5, "word": " اللي", "probability": 0.952392578125}, {"start": 4584.5, "end": 4584.8, "word": " يبقى", "probability": 0.81939697265625}, {"start": 4584.8, "end": 4585.96, "word": " عنده", "probability": 0.92138671875}, {"start": 4585.96, "end": 4586.76, "word": " صلع", "probability": 0.5808919270833334}, {"start": 4586.76, "end": 4586.92, "word": " أو", "probability": 0.94482421875}, {"start": 4586.92, "end": 4587.32, "word": " مستحيل", "probability": 0.81695556640625}, {"start": 4587.32, "end": 4587.76, "word": " منه", "probability": 0.97998046875}, {"start": 4587.76, "end": 4588.38, "word": " مثل", "probability": 0.782958984375}, {"start": 4588.38, "end": 4588.8, "word": " أبيه", "probability": 0.478271484375}, {"start": 4588.8, "end": 4589.34, "word": " بيجيب", "probability": 0.87470703125}, {"start": 4589.34, "end": 4591.84, "word": " ذات", "probability": 0.6544189453125}, {"start": 4591.84, "end": 4592.28, "word": " زلام", "probability": 0.3416748046875}, {"start": 4592.28, "end": 4592.78, "word": " مرات", "probability": 0.9430338541666666}, {"start": 4592.78, "end": 4593.5, "word": " بيخطوها", "probability": 0.8090006510416666}, {"start": 4593.5, "end": 4594.74, "word": " وقنادة", "probability": 0.539697265625}, {"start": 4594.74, "end": 4594.88, "word": " الـ", "probability": 0.842041015625}, {"start": 4594.88, "end": 4595.36, "word": " Atrophy", "probability": 0.665283203125}, {"start": 4595.36, "end": 4596.72, "word": " الـ", "probability": 0.85400390625}, {"start": 4596.72, "end": 4597.42, "word": " Huntington", "probability": 0.715087890625}, {"start": 4597.42, "end": 4598.06, "word": " Disease", "probability": 0.421142578125}, {"start": 4598.06, "end": 4599.28, "word": " الـ", "probability": 0.6807861328125}, {"start": 4599.28, "end": 4599.7, "word": " Caudate", "probability": 0.6213785807291666}, {"start": 4599.7, "end": 4600.44, "word": " Nucleus", "probability": 0.7598876953125}, {"start": 4600.44, "end": 4600.7, "word": " عيب", "probability": 0.6391194661458334}, {"start": 4600.7, "end": 4600.9, "word": " الـ", "probability": 0.912353515625}, {"start": 4600.9, "end": 4601.3, "word": " Brain", "probability": 0.74072265625}, {"start": 4601.3, "end": 4603.18, "word": " مافيش", "probability": 0.9012044270833334}, {"start": 4603.18, "end": 4603.5, "word": " فيها", "probability": 0.991943359375}, {"start": 4603.5, "end": 4604.7, "word": " Acetylcholine", "probability": 0.849609375}, {"start": 4604.7, "end": 4605.78, "word": " ولا", "probability": 0.87158203125}, {"start": 4605.78, "end": 4607.66, "word": " الجابا", "probability": 0.7272135416666666}], "temperature": 1.0}, {"id": 165, "seek": 463293, "start": 4608.11, "end": 4632.93, "text": "اللي هو الـ Neurotransmitters فكوديت أسيتالكولين جابها CAG وهي Cataract وTop T وGonadal Atrophy CTG وهيك يعني أنا", "tokens": [6027, 20292, 31439, 2423, 39184, 1734, 374, 310, 25392, 3508, 1559, 6156, 4117, 23328, 36081, 5551, 3794, 36081, 6027, 4117, 12610, 9957, 10874, 16758, 11296, 22852, 38, 37037, 1829, 9565, 289, 578, 4032, 50118, 314, 4032, 38, 266, 345, 304, 1711, 40826, 19529, 38, 37037, 1829, 4117, 37495, 22653, 41850], "avg_logprob": -0.43566177288691205, "compression_ratio": 1.1347517730496455, "no_speech_prob": 0.0, "words": [{"start": 4608.11, "end": 4608.43, "word": "اللي", "probability": 0.815185546875}, {"start": 4608.43, "end": 4608.93, "word": " هو", "probability": 0.9501953125}, {"start": 4608.93, "end": 4610.87, "word": " الـ", "probability": 0.56500244140625}, {"start": 4610.87, "end": 4612.27, "word": " Neurotransmitters", "probability": 0.8113606770833334}, {"start": 4612.27, "end": 4613.75, "word": " فكوديت", "probability": 0.54010009765625}, {"start": 4613.75, "end": 4615.69, "word": " أسيتالكولين", "probability": 0.7706124441964286}, {"start": 4615.69, "end": 4616.33, "word": " جابها", "probability": 0.7428385416666666}, {"start": 4616.33, "end": 4619.07, "word": " CAG", "probability": 0.6640625}, {"start": 4619.07, "end": 4620.65, "word": " وهي", "probability": 0.5374755859375}, {"start": 4620.65, "end": 4621.53, "word": " Cataract", "probability": 0.7257486979166666}, {"start": 4621.53, "end": 4622.23, "word": " وTop", "probability": 0.49169921875}, {"start": 4622.23, "end": 4622.87, "word": " T", "probability": 0.5576171875}, {"start": 4622.87, "end": 4624.37, "word": " وGonadal", "probability": 0.76904296875}, {"start": 4624.37, "end": 4625.13, "word": " Atrophy", "probability": 0.91845703125}, {"start": 4625.13, "end": 4627.17, "word": " CTG", "probability": 0.914794921875}, {"start": 4627.17, "end": 4628.37, "word": " وهيك", "probability": 0.5980631510416666}, {"start": 4628.37, "end": 4630.29, "word": " يعني", "probability": 0.948486328125}, {"start": 4630.29, "end": 4632.93, "word": " أنا", "probability": 0.8037109375}], "temperature": 1.0}, {"id": 166, "seek": 465999, "start": 4636.65, "end": 4659.99, "text": "أحنا يوم الأربعة ممكن نكمل، ماشي أنا أسا عندى تدريس تانى وبضطر أترككم هلأ، ماشي إذا حد عنده أسئلة يحط على group medical genetics وإن شاء الله يوم الأربعة بنكمل، ماشي الله يوفقكم", "tokens": [10721, 5016, 8315, 7251, 20498, 16247, 25513, 27884, 3714, 43020, 8717, 24793, 1211, 12399, 3714, 33599, 1829, 41850, 5551, 3794, 995, 43242, 7578, 6055, 3215, 16572, 3794, 6055, 7649, 7578, 4032, 3555, 11242, 9566, 2288, 5551, 2655, 31747, 24793, 8032, 1211, 10721, 12399, 3714, 33599, 1829, 11933, 15730, 11331, 3215, 43242, 3224, 5551, 3794, 19986, 37977, 7251, 5016, 9566, 15844, 1594, 4625, 26516, 4032, 28814, 1863, 13412, 16606, 21984, 7251, 20498, 16247, 25513, 27884, 44945, 24793, 1211, 12399, 3714, 33599, 1829, 21984, 7251, 38688, 4587, 24793], "avg_logprob": -0.21228448823950757, "compression_ratio": 1.650273224043716, "no_speech_prob": 2.0623207092285156e-05, "words": [{"start": 4636.650000000001, "end": 4637.85, "word": "أحنا", "probability": 0.4760538736979167}, {"start": 4637.85, "end": 4638.59, "word": " يوم", "probability": 0.907958984375}, {"start": 4638.59, "end": 4639.15, "word": " الأربعة", "probability": 0.880859375}, {"start": 4639.15, "end": 4639.55, "word": " ممكن", "probability": 0.97021484375}, {"start": 4639.55, "end": 4640.35, "word": " نكمل،", "probability": 0.7957763671875}, {"start": 4640.35, "end": 4640.73, "word": " ماشي", "probability": 0.75439453125}, {"start": 4640.73, "end": 4641.35, "word": " أنا", "probability": 0.67724609375}, {"start": 4641.35, "end": 4641.73, "word": " أسا", "probability": 0.5890299479166666}, {"start": 4641.73, "end": 4642.29, "word": " عندى", "probability": 0.679931640625}, {"start": 4642.29, "end": 4642.89, "word": " تدريس", "probability": 0.958251953125}, {"start": 4642.89, "end": 4643.45, "word": " تانى", "probability": 0.8297526041666666}, {"start": 4643.45, "end": 4644.99, "word": " وبضطر", "probability": 0.693701171875}, {"start": 4644.99, "end": 4645.59, "word": " أترككم", "probability": 0.9461669921875}, {"start": 4645.59, "end": 4646.33, "word": " هلأ،", "probability": 0.822265625}, {"start": 4646.33, "end": 4646.77, "word": " ماشي", "probability": 0.90625}, {"start": 4646.77, "end": 4647.41, "word": " إذا", "probability": 0.804443359375}, {"start": 4647.41, "end": 4647.71, "word": " حد", "probability": 0.8466796875}, {"start": 4647.71, "end": 4648.07, "word": " عنده", "probability": 0.9931640625}, {"start": 4648.07, "end": 4648.57, "word": " أسئلة", "probability": 0.99267578125}, {"start": 4648.57, "end": 4649.45, "word": " يحط", "probability": 0.9654947916666666}, {"start": 4649.45, "end": 4649.77, "word": " على", "probability": 0.90283203125}, {"start": 4649.77, "end": 4651.05, "word": " group", "probability": 0.7158203125}, {"start": 4651.05, "end": 4653.15, "word": " medical", "probability": 0.61767578125}, {"start": 4653.15, "end": 4654.09, "word": " genetics", "probability": 0.91650390625}, {"start": 4654.09, "end": 4655.09, "word": " وإن", "probability": 0.8834635416666666}, {"start": 4655.09, "end": 4655.31, "word": " شاء", "probability": 0.97998046875}, {"start": 4655.31, "end": 4655.47, "word": " الله", "probability": 0.9501953125}, {"start": 4655.47, "end": 4656.53, "word": " يوم", "probability": 0.94677734375}, {"start": 4656.53, "end": 4656.97, "word": " الأربعة", "probability": 0.986328125}, {"start": 4656.97, "end": 4657.99, "word": " بنكمل،", "probability": 0.8037109375}, {"start": 4657.99, "end": 4658.49, "word": " ماشي", "probability": 0.8860677083333334}, {"start": 4658.49, "end": 4659.35, "word": " الله", "probability": 0.81591796875}, {"start": 4659.35, "end": 4659.99, "word": " يوفقكم", "probability": 0.900390625}], "temperature": 1.0}, {"id": 167, "seek": 466821, "start": 4663.57, "end": 4668.21, "text": "تمام يا دكتور، يعطيك العافية أهلا وسهلا، يالا السلام عليكم السلام عليكم", "tokens": [39237, 10943, 35186, 11778, 4117, 2655, 13063, 12399, 37495, 9566, 1829, 4117, 18863, 31845, 10632, 5551, 3224, 15040, 46952, 3224, 15040, 12399, 7251, 6027, 995, 21136, 37440, 25894, 24793, 21136, 37440, 25894, 24793], "avg_logprob": -0.28722426558242126, "compression_ratio": 1.5057471264367817, "no_speech_prob": 4.76837158203125e-07, "words": [{"start": 4663.57, "end": 4663.99, "word": "تمام", "probability": 0.792724609375}, {"start": 4663.99, "end": 4664.11, "word": " يا", "probability": 0.779296875}, {"start": 4664.11, "end": 4664.43, "word": " دكتور،", "probability": 0.85634765625}, {"start": 4664.43, "end": 4664.67, "word": " يعطيك", "probability": 0.72943115234375}, {"start": 4664.67, "end": 4665.11, "word": " العافية", "probability": 0.9114583333333334}, {"start": 4665.11, "end": 4665.61, "word": " أهلا", "probability": 0.8390299479166666}, {"start": 4665.61, "end": 4666.31, "word": " وسهلا،", "probability": 0.7764892578125}, {"start": 4666.31, "end": 4666.47, "word": " يالا", "probability": 0.6097005208333334}, {"start": 4666.47, "end": 4666.81, "word": " السلام", "probability": 0.8291015625}, {"start": 4666.81, "end": 4667.63, "word": " عليكم", "probability": 0.73974609375}, {"start": 4667.63, "end": 4668.01, "word": " السلام", "probability": 0.930419921875}, {"start": 4668.01, "end": 4668.21, "word": " عليكم", "probability": 0.937744140625}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 4690.221875, "duration_after_vad": 4565.705624999997}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/uzpVhimo_X4_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/uzpVhimo_X4_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..d63e2d496c9ad3442deb83a8ae7581fa413b47a1
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/uzpVhimo_X4_raw.srt
@@ -0,0 +1,3068 @@
+1
+00:00:00,490 --> 00:00:06,230
+يعني إحنا الآن مطلوب من الطلاب إنهم يحلوا الأسئلة
+
+2
+00:00:06,230 --> 00:00:11,510
+اللي في المراجع الموجودة الـ USMLE وغيرها وغيرها
+
+3
+00:00:11,510 --> 00:00:23,620
+وبالتالي يعني يكون إذا في شيء صعبنقشه وراح نبدأ
+
+4
+00:00:23,620 --> 00:00:31,920
+ناخذ يعني سؤال فيه أحدكم بعتليها إنه مش فاهم أو
+
+5
+00:00:31,920 --> 00:00:38,340
+كان فيه صعوبة فبحاول
+
+6
+00:00:38,340 --> 00:00:42,920
+إن الأشياء اللي يعني شعرت إنه يمكن ماشددتش عليها
+
+7
+00:00:42,920 --> 00:00:49,930
+واضحكتها بالنسبة للمحاضرةنتكلم عنها ونشوف كيف
+
+8
+00:00:49,930 --> 00:00:59,090
+الموضوع وكيف بيجي يعني النقطة الأولى فيه اللي هو
+
+9
+00:00:59,090 --> 00:01:02,390
+موضوع الـLinkage Equilibrium وLinkage
+
+10
+00:01:02,390 --> 00:01:09,510
+Desequilibrium تواتر الإتزان وعدم الإتزان في
+
+11
+00:01:09,510 --> 00:01:20,540
+الترابطأحنا هنا السؤال يقول إنه درجة قرب موقعين
+
+12
+00:01:20,540 --> 00:01:28,320
+two loci for two genes مثلًا، أنا المثال اللي
+
+13
+00:01:28,320 --> 00:01:35,600
+دائمًا بضربه اللي هو الـHLA-A بعيد عن الـB بس
+
+14
+00:01:35,600 --> 00:01:42,800
+الـHLA-C قريب جدًا عن الـBحكيت هذا الكلام، دخل حتى
+
+15
+00:01:42,800 --> 00:01:48,600
+سريرياً إنه إحنا لما نعمل HLA-Typing لما نقرر
+
+16
+00:01:48,600 --> 00:01:55,640
+عمليات نقل الأعضاء وما نقل الأعضاء وكذا نفحص على
+
+17
+00:01:55,640 --> 00:02:01,520
+الـA وعلى الـB الـC لأنه مربوط مع الـB حتى ما
+
+18
+00:02:01,520 --> 00:02:07,040
+بنحتاج نفحص عليه فالفكرة تبعتها، اللي هي إنه بنقول
+
+19
+00:02:07,040 --> 00:02:14,000
+فيه Linked disequilibriumبسبب الترابط لأنه قريبات
+
+20
+00:02:14,000 --> 00:02:20,940
+على بعض إذا كان الـ B شكل معين الـ C بكون شكل محدد
+
+21
+00:02:20,940 --> 00:02:26,200
+كمان يعني في ارتباط زيادة فالـ
+
+22
+00:02:26,830 --> 00:02:30,510
+المثال اللي حاطينه بالـ Figure اللي بفرجيكم إياه
+
+23
+00:02:30,510 --> 00:02:36,470
+وإذا بحط Share Screen دقيقة
+
+24
+00:02:36,470 --> 00:02:46,050
+إذا بحط Share Screen اللي هو هذا المثال خلينا
+
+25
+00:02:46,050 --> 00:02:51,730
+هيك نقرأ الأرقام هذه في
+
+26
+00:02:51,730 --> 00:02:57,370
+الحالة الأولى نفترض إكتراضًاإنه أنا عندي Two Loci
+
+27
+00:02:57,370 --> 00:03:00,590
+واندي
+
+28
+00:03:00,590 --> 00:03:08,190
+Two Alleles يعني في كل الـGene في كل محل فيه
+
+29
+00:03:08,190 --> 00:03:15,110
+نسختين أو نوعين مختلفين من الـ… يعني مثلًا أنا
+
+30
+00:03:15,110 --> 00:03:20,590
+بتكلم عن الـABO System والـRh System هذولة Two
+
+31
+00:03:20,590 --> 00:03:27,980
+Loci واحد في الـABOبكون يا «A» يا «B» يا «O» والـ
+
+32
+00:03:27,980 --> 00:03:32,500
+«RH» يا بكون Positive أو Negative الـ Capital «D»
+
+33
+00:03:32,500 --> 00:03:36,540
+أو الـ Small «D»، «A» في الـ «N» بعضًا فإذا أنا
+
+34
+00:03:36,540 --> 00:03:44,160
+جيت مثلًا في الـ Locus «A» كان عندي مثلًا نفترض
+
+35
+00:03:44,160 --> 00:03:47,120
+الـ «A» الـ Capital والـ «A» الـ Small أنا عارف
+
+36
+00:03:47,120 --> 00:03:56,500
+إنهم 0.5 إلى 2.0هدولة بيعطونا الـ الـ الـ الـ
+
+37
+00:03:56,500 --> 00:04:06,080
+frequencies تبع الأليل اللي أنا عارفه ماشي وبعدين
+
+38
+00:04:06,080 --> 00:04:15,160
+اللقس التاني point oneالـ capital S والـ small s
+
+39
+00:04:15,160 --> 00:04:22,940
+هو point nine يعني هنا السائد عشرة بالنية والمتنحي
+
+40
+00:04:22,940 --> 00:04:27,380
+تسعين بالنية فإذا
+
+41
+00:04:27,380 --> 00:04:34,960
+بلاقي النسب للإثنين هذولة لما أتي أتحسن نفس
+
+42
+00:04:34,960 --> 00:04:40,320
+الإنسان للـ two low psi وأشوف شو الأليل اللي موجود
+
+43
+00:04:40,320 --> 00:04:44,260
+عنده في كل الأماكناللي هم المكانين هنا اللي أنا
+
+44
+00:04:44,260 --> 00:04:49,420
+بفحص عليهم، الـTwo copies وبلاقي النسب بهذه
+
+45
+00:04:49,420 --> 00:04:57,180
+الطريقة معناته إنه هذولة الـTwo loci ما لهم أي
+
+46
+00:04:57,180 --> 00:05:04,980
+ترابط مافي بينهم دخل، لأن نسبهم نسب يعني هي
+
+47
+00:05:04,980 --> 00:05:10,860
+المتوقعة من الـGeneral populationمن المعرفة
+
+48
+00:05:10,860 --> 00:05:16,060
+السابقة عندي بالنسبة للنسبة للـ «الليل» هدولة
+
+49
+00:05:16,060 --> 00:05:22,100
+وdistribution تبعاتهم بالـ population لو أنا مثلا
+
+50
+00:05:22,100 --> 00:05:33,640
+تفقدت كتالة الـ «Okay» هذا 0.1% الـ «locus 2» الـ
+
+51
+00:05:33,640 --> 00:05:40,870
+«S» والـ «locus 2» الـ «small s»0.9، هذه 10% وهذه
+
+52
+00:05:40,870 --> 00:05:48,050
+90% فأنا عارف إنه الأصل هدولة نص بنص آجي ألاقي إن
+
+53
+00:05:48,050 --> 00:05:51,910
+اللي عندهم capital A و capital S مافيش ولا حد بهذا
+
+54
+00:05:51,910 --> 00:05:59,010
+الشكل يعني كل اللي عندهم capital S طلع عندهم small
+
+55
+00:05:59,010 --> 00:06:06,110
+a فإذن في اغتباط في الحالة هذه لأن هذه النسب مش
+
+56
+00:06:06,110 --> 00:06:12,950
+نتيجة ضربالمعروف والمعلوم من نسب الـ Alleles اللي
+
+57
+00:06:12,950 --> 00:06:19,150
+موجودة في كل شيء فلما أشوف أنا بهذا الشكل وهنا
+
+58
+00:06:19,150 --> 00:06:24,970
+يعني المفروض هي 0.1 و هي 0.5، 0.5 يعني نصهم هيك و
+
+59
+00:06:24,970 --> 00:06:32,210
+نصهم هيك، هيك الأصل وهنا الأصل إذا 90% لازم يكون
+
+60
+00:06:32,210 --> 00:06:36,530
+نصهم هيك و نصهم هيك لما أشوف الاختلالات بهذا الشكل
+
+61
+00:06:36,530 --> 00:06:43,340
+معناته أنهفيه ارتباط وبالتالي مافيش توازن بالنسب
+
+62
+00:06:43,340 --> 00:06:48,000
+تبعاتهم نسميه linkage disequilibrium وهذه الظاهرة
+
+63
+00:06:48,000 --> 00:06:53,620
+ممكن تكون يعني مش قوية تماماً بهذا الشكل فيه ممكن
+
+64
+00:06:53,620 --> 00:06:57,620
+تكون شكل جزئي فبالتالي فيه بيصير linkage
+
+65
+00:06:57,620 --> 00:07:02,820
+disequilibrium partial بهذا الشكل يعني أرجو أنها
+
+66
+00:07:02,820 --> 00:07:07,190
+تكون واضحة وهذه النقطة الأولىبحب أؤكد عليها من
+
+67
+00:07:07,190 --> 00:07:16,410
+مراجعة الـ Quiz تبع المرة اللي كانت فيه أسئلة؟ ‏-
+
+68
+00:07:16,410 --> 00:07:18,950
+أعطيك العافية يا أخته ‏- الله يعفوك يا أستاذ
+
+69
+00:07:18,950 --> 00:07:23,330
+الكريم، أتفضل ‏- الأخته دلوقتي أسئلة أنت هرجيتها و
+
+70
+00:07:23,330 --> 00:07:26,810
+لا فيها قبل ‏- أنا بقى أشتغلت في سؤال على السؤال
+
+71
+00:07:26,810 --> 00:07:33,630
+اللي لسه شرحته ‏- هلأ تمام بس ‏- نعم ‏- هلأ تمام،
+
+72
+00:07:33,630 --> 00:07:38,630
+بس في حاجة تانيةاللي هي بس إذا حد عنده عنهاي
+
+73
+00:07:38,630 --> 00:07:42,890
+وبعدين فيه نقطة ثانية بس هيك بده أرجعها مرة ثانية
+
+74
+00:07:42,890 --> 00:07:47,390
+وبعدين فيه سؤال اللي واحد بعثني إياه على
+
+75
+00:07:47,390 --> 00:07:54,610
+الـWhatsApp بدخل عليه وبنشوفه وبعدين أي حد عنده أي
+
+76
+00:07:54,610 --> 00:08:00,270
+سؤال بنرجعه بنفرجيني من وين سؤاله وبنتكلم عنه فبس
+
+77
+00:08:00,270 --> 00:08:01,770
+في حد عنده سؤال هذا
+
+78
+00:08:09,980 --> 00:08:19,280
+طيب النقطة التانية حابب إنه تكون واضحة عندكم اللي
+
+79
+00:08:19,280 --> 00:08:24,940
+هي الفرق بين الـ Association و الـ Linkage يعني
+
+80
+00:08:24,940 --> 00:08:33,040
+المواضيع في هذا الجزء يعني هو فصل بعنوان «identify
+
+81
+00:08:33,040 --> 00:08:36,560
+the genetic basis of human disease» يعني كيف أنا
+
+82
+00:08:36,560 --> 00:08:47,300
+بديأدخل معرفتي بالـ… بالـGenetics واستخدام الـPCR
+
+83
+00:08:47,300 --> 00:08:53,480
+والتركيب الدقيق للجيل في المرض أو على الأمراض
+
+84
+00:08:53,480 --> 00:08:57,700
+فالنقطة
+
+85
+00:08:57,700 --> 00:09:02,520
+المهمة يعني الواحد يكون فاهمها اللي هي إنه أنا
+
+86
+00:09:02,520 --> 00:09:10,530
+مرات نتكلم مثلًاعلى إن الـ HLA-B27 is linked to
+
+87
+00:09:10,530 --> 00:09:16,550
+ankylosing spondylitis أو إذا فيه أندياشي بنسميه
+
+88
+00:09:16,550 --> 00:09:20,850
+association يعني فيه كلمة مرات بيستخدموا كلمة
+
+89
+00:09:20,850 --> 00:09:26,170
+linkage ومرات بيستخدموا association فالـ linkage
+
+90
+00:09:26,170 --> 00:09:32,050
+وهي يعني زي ما أنتم شايفين هنا عبارة عن مجموعة
+
+91
+00:09:32,050 --> 00:09:34,470
+نقاط ماشي
+
+92
+00:09:36,840 --> 00:09:43,520
+بتفرّك بين أمتى أستخدم كلمة أنا في ارتباط وفي
+
+93
+00:09:43,520 --> 00:09:49,120
+علاقة يعني هم الكلمات متشابهة بس بتكلم عن نقاط
+
+94
+00:09:49,120 --> 00:09:54,060
+شويه مختلفة فلما نقول linkage هو it follows the
+
+95
+00:09:54,060 --> 00:09:58,780
+inheritance of the disease trait and regions of
+
+96
+00:09:58,780 --> 00:10:03,120
+the genome from individual to individual in family
+
+97
+00:10:03,120 --> 00:10:13,090
+by degreesيعني لما أنا أجيب آلة فيها مثلا أشخاص
+
+98
+00:10:13,090 --> 00:10:18,530
+مصابين وفيها أشخاص طبيعيين، هاي اسمها linkage،
+
+99
+00:10:18,530 --> 00:10:23,950
+ماشي الـ Association اللي
+
+100
+00:10:23,950 --> 00:10:28,890
+هي لما نكون في test للـaltered frequency of
+
+101
+00:10:28,890 --> 00:10:32,470
+particular alleys or haplotypes in affected
+
+102
+00:10:32,470 --> 00:10:37,210
+individuals comparedwith controls in a population
+
+103
+00:10:37,210 --> 00:10:49,630
+يعني هنا ال .. ال .. يعني أنا بسوي إشي مشابه هو
+
+104
+00:10:49,630 --> 00:10:56,020
+أنا بجيب الناس عندهم المرض وفيه ناس سليمينوبشوف
+
+105
+00:10:56,020 --> 00:11:06,340
+الفرق بين نسب الخدوط الـ Certain Alleles أو
+
+106
+00:11:06,340 --> 00:11:09,820
+اللياشي اللي أنا بدرس عليه أو الـ Hablotype بطريقة
+
+107
+00:11:09,820 --> 00:11:15,780
+معينة بين مجموعة مصابة وبين الـGeneral Population
+
+108
+00:11:15,780 --> 00:11:19,800
+فهنا بنقولها Association، فديك بسميها Linkage
+
+109
+00:11:23,250 --> 00:11:27,770
+الـ «التواصل» يبحث عن مقاطع الجنوم اللي تتعامل مع
+
+110
+00:11:27,770 --> 00:11:30,270
+الـ Disease Alleles ويستخدم الـ Polymorphic
+
+111
+00:11:30,270 --> 00:11:36,270
+Variants فقط كطريقة لتواصل أي مقاطع تتعامل معها من
+
+112
+00:11:36,270 --> 00:11:43,830
+أي والد. وهي برضه، يعني، الـ «تواصل» يستخدم الـ
+
+113
+00:11:43,830 --> 00:11:46,610
+Hundred الـ «تواصل» يستخدم الـ Hundred لـ
+
+114
+00:11:46,610 --> 00:11:53,730
+Thousands of Polymorphic Markers عبر الجنومالتي
+
+115
+00:11:53,730 --> 00:12:00,190
+ليست مصممة لإيجار الـ Variant المسؤول عنها أو تسبب
+
+116
+00:12:00,190 --> 00:12:04,930
+في المرض يمكن أن يتمارك أين يمكن أن تجد الـ
+
+117
+00:12:04,930 --> 00:12:12,030
+Variant في عامة واحد أو عامة ميجابيزيات يعني لما
+
+118
+00:12:12,030 --> 00:12:18,840
+أقول أنا فيه Linkage أناما حتى يعني بحاول إن حد
+
+119
+00:12:18,840 --> 00:12:23,500
+تقنعه الـ Specific Variant إحنا حتى بيكون الـ
+
+120
+00:12:23,500 --> 00:12:34,940
+Linkage مع اللي هو قطعة كامة الـ Linkage relies on
+
+121
+00:12:34,940 --> 00:12:38,240
+recombination
+
+122
+00:12:38,240 --> 00:12:43,180
+events occurring in families during only a few
+
+123
+00:12:43,180 --> 00:12:45,970
+generations to allow«مقارنة مقارنة المقارنة
+
+124
+00:12:45,970 --> 00:12:49,690
+الجينية بين جنود المرض ومقارنة مقارنة مقارنة المرض
+
+125
+00:12:49,690 --> 00:12:50,910
+ومقارنة مقارنة المرض ومقارنة مقارنة المرض ومقارنة
+
+126
+00:12:50,910 --> 00:12:51,710
+مقارنة المرض ومقارنة المرض ومقارنة المرض ومقارنة
+
+127
+00:12:51,710 --> 00:12:55,470
+المرض ومقارنة المرض ومقارنة المرض ومقارنة المرض
+
+128
+00:12:55,470 --> 00:12:55,850
+ومقارنة المرض ومقارنة المرض ومقارنة المرض ومقارنة
+
+129
+00:12:55,850 --> 00:12:55,850
+المرض ومقارنة المرض ومقارنة المرض ومقارنة المرض
+
+130
+00:12:55,850 --> 00:12:59,450
+ومقارنة المرض ومقارنة المرض ومقارنة المرض ومقارنة
+
+131
+00:12:59,450 --> 00:13:09,240
+المرض ومقارنةما بكون ما هو اسمه؟ ما بكون يعني ربطة
+
+132
+00:13:09,240 --> 00:13:14,720
+الـ Disease بالمرض مع الـ Gene هذا يعني إحنا لما
+
+133
+00:13:14,720 --> 00:13:23,300
+درسنا مثلا البيئة الـ S-Hemoglobin variation مقابل
+
+134
+00:13:23,300 --> 00:13:28,780
+الـ Sickle Cell Disease علينا نفهم ليش هذا الـ
+
+135
+00:13:28,780 --> 00:13:34,180
+Gene بدأأما لما أنا أعمل linkage يمكن اللي أنا
+
+136
+00:13:34,180 --> 00:13:41,300
+بربطه مع المرض هو مكان أنا يعني بيحتوي أو قريب من
+
+137
+00:13:41,300 --> 00:13:45,540
+الـGene تبع الـDisease بس أنا مابكون بعرف ليش أو
+
+138
+00:13:45,540 --> 00:13:50,060
+كيف هذا بيؤدي للمرض Require sampling of families
+
+139
+00:13:50,060 --> 00:13:53,540
+not just people affected with the disease I
+
+140
+00:13:53,540 --> 00:13:58,930
+بالـLinkageLoses power when disease has complex
+
+141
+00:13:58,930 --> 00:14:01,870
+inheritance and substantial lack of penetrance
+
+142
+00:14:01,870 --> 00:14:09,410
+more often أو
+
+143
+00:14:09,410 --> 00:14:14,510
+most often used to map disease-causing mutations
+
+144
+00:14:14,510 --> 00:14:17,930
+with strong enough effect to cause a Mendelian
+
+145
+00:14:17,930 --> 00:14:22,610
+inheritance pattern يعني الفكرة اللي بدي أوصلها
+
+146
+00:14:22,610 --> 00:14:31,500
+إنه عملية الـ linkageهي عملية يعني إن أنا أقول
+
+147
+00:14:31,500 --> 00:14:38,640
+نتيجة دراسة عائلة فيها ناس مصابين وناس مش مصابين
+
+148
+00:14:38,640 --> 00:14:46,540
+إن أنا قدرت أحدد علاقي مكاني في الـGenome في
+
+149
+00:14:46,540 --> 00:14:54,170
+ارتباط بينه وبين الـ… بينه وبين الـDiseaseوبكون
+
+150
+00:14:54,170 --> 00:15:00,850
+أنا اللي بستخدمه كـ Marker لمعرفة هذا الإرتباط ليس
+
+151
+00:15:00,850 --> 00:15:06,790
+بالضرورة مفسر أو شارع أو محدد لقالية تسبب المرض
+
+152
+00:15:06,790 --> 00:15:11,900
+يعني ممكن اللي أنا المنطقة اللي أربطها مع المرضهي
+
+153
+00:15:11,900 --> 00:15:20,780
+منطقة يعني مش يعني ما فيها إشي أنا بقدر كـ Disease
+
+154
+00:15:20,780 --> 00:15:27,000
+زي الـ S-Hemoglobin وSickle Cell Disease أقول هذا
+
+155
+00:15:27,000 --> 00:15:30,800
+هيك يسوي المرض هيك فهذه العلاقة اللي هي في قضية
+
+156
+00:15:30,800 --> 00:15:34,550
+الـ Language أما لما نحكي Associationالـ
+
+157
+00:15:34,550 --> 00:15:42,390
+Association هي دراسات على مستوى بتكون على مستوى
+
+158
+00:15:42,390 --> 00:15:45,770
+يعني مختلف اللي هو الـ frequency of the alien
+
+159
+00:15:45,770 --> 00:15:52,210
+between group of patients و group of controls في
+
+160
+00:15:52,210 --> 00:16:00,050
+ال population فهي يعني اللي كنت حابب نقطة تانية من
+
+161
+00:16:00,050 --> 00:16:00,570
+حقها
+
+162
+00:16:04,020 --> 00:16:13,100
+النقطة الأخيرة بدي أفرجيكم إياها ثواني عشان نسوي
+
+163
+00:16:13,100 --> 00:16:20,680
+share screen اللي هو سؤال بعضكم طرحه فيه إشي مش
+
+164
+00:16:20,680 --> 00:16:28,040
+فاهمي، مش فاهمي اللي هو خلّينا ننزل في السؤال لحد
+
+165
+00:16:28,040 --> 00:16:30,800
+ما نشوفه أظن بيجي بعدين
+
+166
+00:16:49,900 --> 00:16:54,740
+سؤال؟ كريم، عندك سؤال؟ حبيبما ألاقي السؤال، هلأ
+
+167
+00:16:54,740 --> 00:17:00,920
+أنا
+
+168
+00:17:00,920 --> 00:17:08,260
+شرح مش سؤال، هو يعني إيه؟ نعم، أه تفضل، احكي لأ،
+
+169
+00:17:08,260 --> 00:17:13,410
+في مواضيع من الـFirst Aidبس ممكن تشرحها، تريد
+
+170
+00:17:13,410 --> 00:17:22,490
+شرحها يعني؟ ماشي، طيب، بقدر تعمل share screen؟
+
+171
+00:17:22,490 --> 00:17:28,690
+بقدر أبعد لك صورة بسك؟ نعم أبعد الصورة في الـchat
+
+172
+00:17:28,690 --> 00:17:36,350
+وتنزلها من داك؟ إذا الـadmin بقدر يخليك تقدر تسوي
+
+173
+00:17:36,350 --> 00:17:42,800
+share screen مباشرة هذولة شفت الصور تبعت الـلما
+
+174
+00:17:42,800 --> 00:17:50,060
+الواحد يخطط تبعتلي إيش وبعدين أنا أبعته كده فبشوف
+
+175
+00:17:50,060 --> 00:18:00,740
+إنه ما بطلع كويس، يعني مش كويس طيب،
+
+176
+00:18:00,740 --> 00:18:08,090
+خلّينا نراجح هذا السؤالوبعدين من برضه الـUSMLE أو
+
+177
+00:18:08,090 --> 00:18:11,910
+CABLAN أو Genetics وكذا، من هنا الـReferences،
+
+178
+00:18:11,910 --> 00:18:19,010
+ماشي؟ يعني عشان تحلوا الأسئلة كويسة أول شيء، لازم
+
+179
+00:18:19,010 --> 00:18:27,470
+الواحد يقرأ السؤال كامل، يقرأ بفهم وشكل عامل، بقول
+
+180
+00:18:27,470 --> 00:18:31,990
+لك، young couple has undergone a successful in
+
+181
+00:18:31,990 --> 00:18:36,970
+-vitro fertilizationالأب يمتلئ بـ Cystic Fibrosis
+
+182
+00:18:36,970 --> 00:18:43,290
+والأم يمتلئ بأخت مع Cystic Fibrosis فرسمي لك الـ
+
+183
+00:18:43,290 --> 00:18:46,990
+Pedigree هنا يعني إذا الواحد إن شاء الله الـ
+
+184
+00:18:46,990 --> 00:18:55,270
+cursor واضح هذا الأب هو مصاب والأم عندها أخت مصابة
+
+185
+00:18:55,270 --> 00:19:03,310
+فهي الـ Pedigree بهذا الشكل هدولة سود يعني مصابين
+
+186
+00:19:04,760 --> 00:19:10,700
+والأثنين عندهم نفس الـ Mutation اللي هو Delta F508
+
+187
+00:19:10,700 --> 00:19:18,020
+يعني في الـ Position 508 فيه إشي اختلف ويعني اتغير
+
+188
+00:19:18,020 --> 00:19:23,940
+بهاي رمز الـ Mutation المجهول
+
+189
+00:19:23,940 --> 00:19:28,800
+هو الـ Mother's career status is unknown يعني هذه
+
+190
+00:19:28,800 --> 00:19:34,890
+الأم صراحة احنا حاليا مش عارفينهل هي career ولا
+
+191
+00:19:34,890 --> 00:19:39,890
+normal؟ بس phenotypically مظهريًا she looks normal
+
+192
+00:19:39,890 --> 00:19:44,790
+مش مصابة before making a decision to conceive the
+
+193
+00:19:44,790 --> 00:19:47,470
+couple underwent extensive genetic counseling
+
+194
+00:19:47,470 --> 00:19:51,450
+regarding the potential risks of having a child
+
+195
+00:19:51,450 --> 00:19:56,290
+with cystic fibrosis تفضلي بـ degree is diagrammed
+
+196
+00:19:56,290 --> 00:20:00,950
+below with the unborn child marked with the red R
+
+197
+00:20:02,580 --> 00:20:05,680
+What is the probability that the unborn child has
+
+198
+00:20:05,680 --> 00:20:12,960
+cystic fibrosis؟ شو احتمالية أنه اللي عليه هذا،
+
+199
+00:20:12,960 --> 00:20:16,300
+اللي حاطينه في هذا الشكل معين لأن لا هما يعرفين
+
+200
+00:20:16,300 --> 00:20:21,020
+لسه ولد ولا ابنه، ماشي، فحاطينها بهذا الشكل
+
+201
+00:20:21,020 --> 00:20:27,860
+وبالنسبة للمعلومات المعروفة اللي هي أن الأب مصاب
+
+202
+00:20:27,860 --> 00:20:38,050
+وأخت الأم مصابةفشو الـ Risk بالنسبة للجنين هذا؟
+
+203
+00:20:38,050 --> 00:20:45,710
+بالنسبة لما نكون، يعني بدكم اتفرجوا بين شغلتين في
+
+204
+00:20:45,710 --> 00:20:51,790
+حال هذا السؤال، بدك تتفرج بين لما تكون انت عارف،
+
+205
+00:20:51,790 --> 00:20:59,140
+لما تكون انت مش عارف، لما تكون عارفبتطبّق النسب
+
+206
+00:20:59,140 --> 00:21:05,000
+اللي أنت بتعرفها بالنسبة للنتيجة
+
+207
+00:21:05,000 --> 00:21:12,460
+لما تكون مش عارف حين تكملت السؤال Bank of Sen
+
+208
+00:21:12,460 --> 00:21:20,240
+بتقول بتطبّق الـConditional Probability يعني نظرية
+
+209
+00:21:20,240 --> 00:21:30,360
+الاحتمالات المشروبة ماشي؟ الآنلو احنا أخذنا مثل
+
+210
+00:21:30,360 --> 00:21:37,860
+هذا الـ B-degree لو أنا مش عارف شو الحاجة، ماشي من
+
+211
+00:21:37,860 --> 00:21:41,100
+ال .. يعني الـ Cystic Fibrosis معروف Extinct
+
+212
+00:21:41,100 --> 00:21:46,240
+Recesses أسف، Autosomal Recesses، ماشي؟ هو
+
+213
+00:21:46,240 --> 00:21:47,400
+Autosomal Recesses
+
+214
+00:21:50,340 --> 00:21:56,480
+بس لما نطلع الـ B-degree هذا النقطة الأولى إنه
+
+215
+00:21:56,480 --> 00:22:02,800
+ذكوره إناد مصابين فإذن هو مش X-linked الـ X-linked
+
+216
+00:22:02,800 --> 00:22:07,120
+يكون أكتر ذكور أو يعني بالذات بقى X-linked
+
+217
+00:22:07,120 --> 00:22:13,040
+Recessive بتكون ذكوره المصابين الشغل التاني إنه
+
+218
+00:22:13,040 --> 00:22:17,540
+الأباء لهدول المصابين Normal فبالتالي فهو
+
+219
+00:22:17,540 --> 00:22:23,170
+Recessiveوإثنين هم بيحملون الجيل فيعني اللي أنا
+
+220
+00:22:23,170 --> 00:22:29,090
+متأكد منه لآن so far إنه إذا اعتبرنا هذا الجيل
+
+221
+00:22:29,090 --> 00:22:34,210
+الأول اللي هدولة العين تاني هدولة الجيل الثاني
+
+222
+00:22:34,210 --> 00:22:40,870
+اللي هم العائلة اللي بتسأل والجيل الثالث هم ال ..
+
+223
+00:22:40,870 --> 00:22:46,450
+شو اسمه؟ ال .. ال .. الطفل اللي دي لم يولد لسه
+
+224
+00:22:46,450 --> 00:22:48,190
+ماشي؟
+
+225
+00:22:49,720 --> 00:22:55,580
+فإذا أخذنا أي عيلة من هدول العائلات من الجدود كل
+
+226
+00:22:55,580 --> 00:23:05,440
+جد من الجدين في العائلتين أكيد كارين لأنه وخلف إذا
+
+227
+00:23:05,440 --> 00:23:10,880
+اتفقنا إنه فعلا هو أبو الطفل هذا اللي ولد سواء
+
+228
+00:23:10,880 --> 00:23:18,580
+الأب أو الأم في الجيل التاني ماشيإذا الأب الجد هي
+
+229
+00:23:18,580 --> 00:23:22,540
+الجدود الأربعة لازم يكونوا career وهذا أنا أشمشي
+
+230
+00:23:22,540 --> 00:23:31,420
+متأكد منه الأب وأخت الزوجة أكيد مصعبين لأن عندهم
+
+231
+00:23:31,420 --> 00:23:38,380
+homozygous recessive الـ small فهذه أنا متأكد منهم
+
+232
+00:23:38,380 --> 00:23:45,880
+ماشي أسسبالنسبة ل... بما أنه أنا ما فحصت الأم للـ
+
+233
+00:23:45,880 --> 00:23:54,840
+Career State ماشي، بدي أعطي تقدير لقداش احتمالية
+
+234
+00:23:54,840 --> 00:24:04,020
+الجنين هذا يطلع Positive نسبة لقداش الأم، شو اسمه؟
+
+235
+00:24:04,020 --> 00:24:07,860
+احتمالية إنها تكون Career وقداش نسبة إنها تعطي
+
+236
+00:24:07,860 --> 00:24:16,370
+الجيل تبع الإصابة الأبأكيد راح يعطي 100% الـ «جين»
+
+237
+00:24:16,370 --> 00:24:21,210
+تبع الإصابة لأن هو 100% مصاب وبالتالي فإذا هو راح
+
+238
+00:24:21,210 --> 00:24:28,970
+يعطي 100% بالنسبة للأم في الحالة هذه بدنا نطبق ما
+
+239
+00:24:28,970 --> 00:24:32,470
+يسمى الـ Conditional Probability Conditional
+
+240
+00:24:32,470 --> 00:24:37,530
+Probability يعني الاحتماليات المشروطة وفي الحالة
+
+241
+00:24:37,530 --> 00:24:47,980
+هذه بنشوفها كالتاليةالـ بالنسبة للـ يعني شو اللي
+
+242
+00:24:47,980 --> 00:24:52,260
+أثر على الـ conditional probability غير إن الأشياء
+
+243
+00:24:52,260 --> 00:24:57,940
+أحنا بنعرفها أحنا بنعرف لما أثنين carriers
+
+244
+00:24:57,940 --> 00:25:03,880
+يتزاوجوا لـ autosomal recessors الاحتمالات واحد
+
+245
+00:25:03,880 --> 00:25:09,120
+واثنين وواحد من أربعة يعني هم أربع أرباع عادة
+
+246
+00:25:11,130 --> 00:25:16,050
+Capital A Capital A Capital A Small A Capital A
+
+247
+00:25:16,050 --> 00:25:20,230
+Small A Small A Small A مثلًا، أنا عندي أربعة عدد
+
+248
+00:25:20,230 --> 00:25:23,610
+فلمّا
+
+249
+00:25:23,610 --> 00:25:28,850
+نكون heterozygous وCareer
+
+250
+00:25:28,850 --> 00:25:36,970
+إحتماليات منفصلة عن ما يمكن نشوفه، يعني أنا مثلًا
+
+251
+00:25:37,260 --> 00:25:41,200
+لما عائلة يتزوجوا ويقول احتمال نص يجيبوا بلد
+
+252
+00:25:41,200 --> 00:25:47,340
+احتمال نص يجيبوا بنت ممكن ست مرات يطلع كله بنات
+
+253
+00:25:47,340 --> 00:25:52,220
+كله بنات كله بنات كله بنات اللي بعده فيه memory
+
+254
+00:25:52,220 --> 00:25:57,180
+loss يعني ما بتذكر النظام أنه الله أنا جيبت ست
+
+255
+00:25:57,180 --> 00:26:01,140
+ولاة ست بنات من قبل لازم أجيب هسا ولد مافي عندنا
+
+256
+00:26:01,140 --> 00:26:06,060
+أيش زيه يظل الاحتمالية نص بنص يطلع ولد وبنت عادي
+
+257
+00:26:06,060 --> 00:26:12,130
+منفصلةفهذه ظاهرة بتحدث صحيح بس في مرات إذا أنا
+
+258
+00:26:12,130 --> 00:26:13,190
+بعرف شو
+
+259
+00:26:13,190 --> 00:26:29,470
+الـ’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’�
+
+260
+00:26:34,620 --> 00:26:38,120
+فإذا عندها small a وsmall a أنا هايم أتأكد منها
+
+261
+00:26:38,120 --> 00:26:45,720
+الآن الأخت اللي هي أم الجنين اللي عليه السؤال
+
+262
+00:26:45,720 --> 00:26:48,900
+وخاله
+
+263
+00:26:48,900 --> 00:26:59,060
+خال الجنين هذا يعني أخه الأم هنا ماشي عليهم علامة
+
+264
+00:26:59,060 --> 00:27:07,070
+استفهام لأنه احنا يعني مش عارفهي أصل النسب رُبع
+
+265
+00:27:07,070 --> 00:27:13,430
+مُصاب نُص career ورُبع Healthy، Completely Healthy
+
+266
+00:27:13,430 --> 00:27:20,350
+فالفكرة في كلمة Conditional Probability إن أنا بما
+
+267
+00:27:20,350 --> 00:27:26,350
+أني عرفت إن هذا الإنسان مش مُصاب إذا مستحيل يكون
+
+268
+00:27:26,350 --> 00:27:30,710
+small a small a فبتصير عندي النسب مش من أربعة
+
+269
+00:27:30,710 --> 00:27:36,460
+بيصير عندي النسب من ثلاثةفبتصير تلتة مصابة تمامًا
+
+270
+00:27:36,460 --> 00:27:43,960
+وتلتين ماشية بيكونوا Carrier هيك النسب حسب
+
+271
+00:27:43,960 --> 00:27:50,440
+الاحتمالات لأنه هنا وهنا أكيد Carrier وهي مصابة
+
+272
+00:27:50,440 --> 00:27:54,960
+وهنا أكيد طبيعي مظهريًا because typically he is
+
+273
+00:27:54,960 --> 00:28:02,000
+okay أو she is okay فبالتالي لما نيجي ناخد أنه فيه
+
+274
+00:28:02,000 --> 00:28:10,290
+احتمالية تلتةإنه يكون Normal Completely Normal في
+
+275
+00:28:10,290 --> 00:28:16,690
+الحالة دي لما يتزوج هنا راح يكون التلت يعني أو
+
+276
+00:28:16,690 --> 00:28:27,370
+اللي بتضرب النسب ببعض بتكون هنا نص كارية ماشي؟
+
+277
+00:28:27,370 --> 00:28:32,530
+وبالنسبة لـ ال .. يعني ال .. ال ..
+
+278
+00:28:35,700 --> 00:28:45,140
+دقيقة، بالنسبة لما يكون التلتين،
+
+279
+00:28:45,140 --> 00:28:52,160
+يعني هنا إحنا هنا اللي لما تيجي تاقظ مثلا سؤال شو
+
+280
+00:28:52,160 --> 00:28:57,200
+احتمالية إنه الجنين هذا اللي هنا يطلع Completely
+
+281
+00:28:57,200 --> 00:29:02,040
+Normal، Zero لأنه أكيد راح يفتد واحد من الجيل
+
+282
+00:29:02,040 --> 00:29:07,070
+المضروب من أبوهفإذن هو مستحيل يطلع normal شو
+
+283
+00:29:07,070 --> 00:29:15,270
+احتمالية إنه يطلع career ماشي اللي لما يكون هذا
+
+284
+00:29:15,270 --> 00:29:19,150
+ثلث فشو
+
+285
+00:29:19,150 --> 00:29:24,830
+اسمه؟ راح يكون أكيد 100% career لو كان الأم
+
+286
+00:29:24,830 --> 00:29:30,830
+completely normal فهي ثلث ولمّا
+
+287
+00:29:30,830 --> 00:29:39,100
+يكون الأمعندها تلتين احتمال إنها تكون Career مرة
+
+288
+00:29:39,100 --> 00:29:46,700
+بتعطي، يعني هي تلتين احتمالية إنها تكون Career نص
+
+289
+00:29:46,700 --> 00:29:54,320
+الحالات تبع تلتين بتعطي الجين أو الأليل المصاب ففي
+
+290
+00:29:54,320 --> 00:29:59,540
+الحالة هذه، راح الطفل يكون مصاب ونص الاحتمالات راح
+
+291
+00:29:59,540 --> 00:30:04,090
+يكون تعطي النسقة الطبيعيةفهيطلع الطفل كاريا
+
+292
+00:30:04,090 --> 00:30:11,370
+فبالنسبة للـ Child هذا اللي أبوه مصاب وخالته مصابة
+
+293
+00:30:11,370 --> 00:30:17,970
+في عنده احتمالية ثلث انه يطلع مصاب واحتمالية ثلثين
+
+294
+00:30:17,970 --> 00:30:23,010
+انه يطلع كاريا واحتمالية صخر انه يطلع completely
+
+295
+00:30:23,010 --> 00:30:27,450
+normal فهدولة النسب تبعته فأول سؤال كان شو
+
+296
+00:30:27,450 --> 00:30:33,660
+احتمالية انه يطلع مصاب فهي ثلثهذه النقطة اللي بدنا
+
+297
+00:30:33,660 --> 00:30:38,000
+إياها أرجو أن تكون فاهم للذي سأل والذي سأل أن يكون
+
+298
+00:30:38,000 --> 00:30:47,420
+حاضر معانا في الشرح هذا في أسئلة؟
+
+299
+00:30:47,420 --> 00:30:57,120
+دكتور كريم عندك الشيء الأسئلة اللي بدك إياها من
+
+300
+00:30:57,120 --> 00:30:59,000
+أنه مارجع هذا ولا التاني؟
+
+301
+00:31:01,630 --> 00:31:07,090
+من كتاب First Aid ماعنديش يا First Aid و لا شو هو
+
+302
+00:31:07,090 --> 00:31:10,910
+من ال references اللي احنا حطناهم و لا من محل
+
+303
+00:31:10,910 --> 00:31:14,350
+تاني؟
+
+304
+00:31:14,350 --> 00:31:18,690
+لأ، هذا كتاب نفسه، مش مارجة أسئلة نفس اللي معايا
+
+305
+00:31:18,690 --> 00:31:26,850
+هذا؟ لأ، مارجة أسئلة ما هذا كله أسئلة في اللي هو
+
+306
+00:31:26,850 --> 00:31:32,480
+كتاب Kaplan You Are Sumely Step Oneاللي هو هيك
+
+307
+00:31:32,480 --> 00:31:39,780
+شكله، خلّيني، إيش اسمه؟ Resume shares؟ New shares؟
+
+308
+00:31:39,780 --> 00:31:48,120
+اللي هو هيك إن
+
+309
+00:31:48,120 --> 00:31:52,020
+شاء الله هيك واضح part two medical genetics هدول
+
+310
+00:31:52,020 --> 00:32:00,050
+اللي أعطونيها فيها بالـ بآخر الـ نعممنفع أعمل
+
+311
+00:32:00,050 --> 00:32:06,370
+share scheme من عند دكتور؟ أعمل
+
+312
+00:32:06,370 --> 00:32:12,350
+share scheme من عندك؟ والله الدكتور اللي معانا إذا
+
+313
+00:32:12,350 --> 00:32:16,570
+بتقدر تكليك تعمل share scheme أيوة عمللي عمللي بقى
+
+314
+00:32:16,570 --> 00:32:19,150
+منفع أعمل طيب يالا عمللي
+
+315
+00:32:45,840 --> 00:32:53,680
+طيب، أيوة، أه، أنا عندي واضح حسنا، تمام، في، في
+
+316
+00:32:53,680 --> 00:32:56,200
+أكم المرض هدولة مكررات في ال «first aid»، وشوية
+
+317
+00:32:56,200 --> 00:32:59,470
+حالهم بتفصيل يعني؟وحتى في أسئلة الـ Reward كان
+
+318
+00:32:59,470 --> 00:33:02,590
+بيسأل عنه وبيعطف تفاصيلهم كتير، فإذا ممكن تقيت
+
+319
+00:33:02,590 --> 00:33:09,050
+شرحهم هنا، بحسب ما هو شرحهم في الـ Test. «شو اللي
+
+320
+00:33:09,050 --> 00:33:13,070
+مش مفهوم؟»
+
+321
+00:33:13,070 --> 00:33:19,510
+«يعني إذا بدك تشترك في البردروتس، فيمشي عليه؟ إذا
+
+322
+00:33:19,510 --> 00:33:21,790
+بدك Cystic Fibrosis؟» «يوجد Cystic Fibrosis، فيه
+
+323
+00:33:21,790 --> 00:33:26,130
+تحتيق أمراض تانية»لأ، هذولة مش أمراض، هذولة
+
+324
+00:33:26,130 --> 00:33:49,750
+كيفية………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………�
+
+325
+00:33:50,570 --> 00:34:01,990
+اللي هو يعني مرض في منطقتنا مرض في ال .. ال ..
+
+326
+00:34:01,990 --> 00:34:06,910
+يعني في ال .. اللي هو بيعتبرونا البيض أحنا
+
+327
+00:34:06,910 --> 00:34:11,670
+كوكازيين كوكازيين أنا كوكازيين بالـGeletics تبع
+
+328
+00:34:11,670 --> 00:34:17,370
+العالم يعني لما أنت بتكتب أنت أحنا مش Hispanic ولا
+
+329
+00:34:18,730 --> 00:34:24,050
+African ولا Native American اللي هو «سكيمو» أو إشي
+
+330
+00:34:24,050 --> 00:34:28,410
+زي ذلك الآن
+
+331
+00:34:28,410 --> 00:34:36,210
+هذا مرض بسبب يعني أنا بتذكر أن في أستاذ إلي حكالي
+
+332
+00:34:36,210 --> 00:34:42,990
+عن أول حالة هو شخصها إنه الأم وحكيت أنا كلمة
+
+333
+00:34:42,990 --> 00:34:51,070
+قدامكمبتقولّه بلحس عرق الطفل تبعها اللي هو الجنين
+
+334
+00:34:51,070 --> 00:34:58,030
+أو الببو تبعها بتقولّه مالح كثير يا دكتور يعني حتى
+
+335
+00:34:58,030 --> 00:35:03,550
+مرات هيك لما الواحد ينشف العرق على جبينه ولا كده
+
+336
+00:35:03,550 --> 00:35:09,790
+بتحس إنه باقى ملح ففي مشكلة فيه لقينا بعدين إنه
+
+337
+00:35:09,790 --> 00:35:17,280
+الـ Sodium Chloride Pumpفي الـ… في الـMucous
+
+338
+00:35:17,280 --> 00:35:24,100
+Membranes فيها مشكلة، تعرف عليها؟ فإحنا الآن اللي
+
+339
+00:35:24,100 --> 00:35:29,180
+بنعرفه اللي هو إنه فيه Capital «C» و Capital «F» و
+
+340
+00:35:29,180 --> 00:35:33,580
+«T» و «R» اللي هو «Cystic Fibrosis Transporter
+
+341
+00:35:33,580 --> 00:35:41,360
+Gene» ماشي، هاي الإختصار تبعه «CFTR» طبعا «Gene»
+
+342
+00:35:41,360 --> 00:35:50,020
+بمعنى إنه هناالـ «جين» تبعه، ماشي؟ لما نكتب مثلاً
+
+343
+00:35:50,020 --> 00:35:55,660
+عن البروتين أو عن الـ RNA أو كده، ما بنحطش capital
+
+344
+00:35:55,660 --> 00:36:02,060
+letter، بنحط small letter، فاللي هو Etosomal
+
+345
+00:36:02,060 --> 00:36:06,580
+Recessive Defect بالـ Cystic Fibrosis Transporter
+
+346
+00:36:06,580 --> 00:36:12,760
+Gene موجود على كرموزوم 7، في Commonly Deletion بـ
+
+347
+00:36:13,010 --> 00:36:18,710
+الفنة الألانين بالـ Position 508 هذا الرموز اللي
+
+348
+00:36:18,710 --> 00:36:22,530
+حاطينها it is the most common lethal disease in
+
+349
+00:36:22,530 --> 00:36:29,390
+coccogysium population أكتر مرض قاتل في البيت
+
+350
+00:36:29,390 --> 00:36:37,770
+ورافقه ماشي هنا الآن ال pathophysiology يعني يمكن
+
+351
+00:36:37,770 --> 00:36:40,790
+يلقينا Cystic Fibrosis Transporter Gene
+
+352
+00:36:40,790 --> 00:36:46,900
+Associationأو الـ Linkage من الـ Linkage Studies
+
+353
+00:36:46,900 --> 00:36:51,740
+بس بعدين بدنا نفهم كيف بتسبب المرض فالـ
+
+354
+00:36:51,740 --> 00:36:59,200
+Pathophysiology إنه الـ ATP-gated chloride channel
+
+355
+00:36:59,200 --> 00:37:07,460
+اللي هي Sodium chloride channel بالإنرجي بدخله،
+
+356
+00:37:07,460 --> 00:37:12,840
+بطلّع Sodium وChloride ماشي في الـMucous Membranes
+
+357
+00:37:13,570 --> 00:37:18,070
+بيكون فيه defect وهذا ورح يأثر على الـ lungs والـ
+
+358
+00:37:18,070 --> 00:37:28,990
+GI tract ماشي، فيه الآن يعني النهاية أنه بيصير
+
+359
+00:37:28,990 --> 00:37:33,410
+علنا mutations، misfolded protein، protein
+
+360
+00:37:33,410 --> 00:37:40,110
+returned in the rough endoplasmic reticulumولم يتم
+
+361
+00:37:40,110 --> 00:37:44,090
+توصيله إلى الـ Cell Membrane بسبب أن الـ Chloride
+
+362
+00:37:44,090 --> 00:37:52,170
+بنزل والـ Secretion للـ Water بنزله وبظل الـ
+
+363
+00:37:52,170 --> 00:37:56,430
+Intracellular Chloride Result in compensatory
+
+364
+00:37:56,430 --> 00:38:02,290
+higher Sodium Reabsorption المهم، يعني في ميكانيزم
+
+365
+00:38:02,290 --> 00:38:08,370
+بخربط Sodium Chloride Pump في الـ Mucous Membrane
+
+366
+00:38:08,820 --> 00:38:13,380
+والـ Respiratory tract والـ GI tract حتى في الـ
+
+367
+00:38:13,380 --> 00:38:21,660
+Skin وحتى في الأشياء التانية فالآن كيف نشخصها؟ من
+
+368
+00:38:21,660 --> 00:38:27,700
+أوائل الـ Test اللي هي اللي هو اسمه الـ Chloride
+
+369
+00:38:27,700 --> 00:38:32,340
+يعني اللي بيسميه الـ Sweat Test الـ Sweat Test
+
+370
+00:38:32,340 --> 00:38:40,730
+يعني أبارعاً فحص بتجيبه الطفلبيحطوه بمنشطة وبعدين
+
+371
+00:38:40,730 --> 00:38:46,590
+بيحطوا عليها إشي تمنع تبخر الماء في حيث إنه يخلوه
+
+372
+00:38:46,590 --> 00:38:52,030
+يأرق ويأخذوا العرق تبعه ويفحصوه لمستوى الـ
+
+373
+00:38:52,030 --> 00:38:57,470
+Chloride والسوديوم والأشياء هذه فاللي هذا بيسموه
+
+374
+00:38:57,470 --> 00:39:03,730
+الـ Chloride Concentration in Bicarbene Induced
+
+375
+00:39:03,730 --> 00:39:09,070
+Swiss Test is Diagnosticمش كتير مفيد كتير كتير،
+
+376
+00:39:09,070 --> 00:39:13,810
+يعني في صعوبة إنك أنت تجمع كمية عرق من إنسان بيعرق
+
+377
+00:39:13,810 --> 00:39:21,090
+أو من طفل بيعرق وتجمعها وبعدين تتحص مظبوط يعني
+
+378
+00:39:21,090 --> 00:39:28,290
+اللي بتذكره رقم الـ60 إذا أعلى من 60 بالوحدات
+
+379
+00:39:28,290 --> 00:39:32,890
+تبعتها من ذاكرها لسه هذه بتكون ماشية مع التشكيز
+
+380
+00:39:32,890 --> 00:39:35,170
+هذا فالـ
+
+381
+00:39:36,660 --> 00:39:45,760
+الـ الـ يعني هو إنسان راح يكون عنده مثلا تكرار
+
+382
+00:39:45,760 --> 00:39:51,920
+التهابات بالصدر خراب في وظيفة البنكرياس ومالة
+
+383
+00:39:51,920 --> 00:39:59,260
+ذورشن وستاتورية اللي هي المظاهر تبعتهم ماشي طبعاً
+
+384
+00:39:59,260 --> 00:40:10,580
+ممكن أنا أبحث للجين تبعه ماشيوفي اللي هو الـ
+
+385
+00:40:10,580 --> 00:40:14,340
+«immunoreactive trypsinogen newborn screening
+
+386
+00:40:14,340 --> 00:40:21,740
+method» إذا في عندك منطقة فيهم كثير، ماشي، فهي كيف
+
+387
+00:40:21,740 --> 00:40:25,160
+بنسوي التشبيث، بس يعني غير إنك تدور على الـGen
+
+388
+00:40:25,160 --> 00:40:30,220
+mutation بتقدر تسوي له sweat test، هذا اللي بنقوله
+
+389
+00:40:30,670 --> 00:40:38,870
+وفيه «ترابسينوجين» level يعني بيكون «increased» مع
+
+390
+00:40:38,870 --> 00:40:45,770
+الكلوسيس والـ «هيبوكالينيا» هذولة لأنه يعني المرض
+
+391
+00:40:45,770 --> 00:40:50,330
+راح يخلي الـ «كلورايد» والـ «سوديوم» ينفرزوا برا
+
+392
+00:40:50,330 --> 00:40:58,980
+فالجسم بيحاول يسحبهم لجوا عشان يصير اتزانفلما يصير
+
+393
+00:40:58,980 --> 00:41:03,920
+هذه الشغل زي لما مثلًا واحد يأخذ Mineralocorticoid
+
+394
+00:41:03,920 --> 00:41:10,360
+أو كده نتيجة الموضوع هذا إنه عشان أنا أسحب في
+
+395
+00:41:10,360 --> 00:41:15,680
+الـ«كلاو» وفي الـ… يعني احنا هنا بنحكي عن الـSFTR
+
+396
+00:41:15,680 --> 00:41:22,640
+جين في الـMucous Membranes والـGI
+
+397
+00:41:22,640 --> 00:41:26,810
+tract يعني الـRespiratory tract والـGI tractعندما
+
+398
+00:41:26,810 --> 00:41:29,830
+كان تاني متدخّل كتير في هذه الأشياء الكيلة
+
+399
+00:41:29,830 --> 00:41:36,310
+والـSweat glands وكذا، في الكيلة إذا بدي أسحب الـ
+
+400
+00:41:36,310 --> 00:41:42,910
+Sodium والـ Cloride، بدي أرمي الـ Potassium والـ H
+
+401
+00:41:42,910 --> 00:41:48,570
+-Iron اللي هو الـ Hydrogen فلما أنا أخلص من، يعني
+
+402
+00:41:48,570 --> 00:41:52,650
+عشان أسحب الـ Sodium، بدي أخلص من الـ Potassium،
+
+403
+00:41:52,650 --> 00:41:58,230
+بيصير عندي Hypokalemiaولمّا أضطر عشان أسحب الـ
+
+404
+00:41:58,230 --> 00:42:03,330
+Sodium لدى أخلص من الـ Hydrogen راح يصير أنا بخلص
+
+405
+00:42:03,330 --> 00:42:08,030
+من الـ Acid يظل عندي Alkalosis فهدولة الـ
+
+406
+00:42:08,030 --> 00:42:13,390
+Diagnostic Test ناشي؟ وهي أنت بتشرح عليهم، الآن
+
+407
+00:42:13,390 --> 00:42:20,320
+الـ Complicationsاللي هم Recurrent Infections بالـ
+
+408
+00:42:20,320 --> 00:42:27,040
+Respiratory Tract شو اسمه؟ يعني هاي راح تسمي
+
+409
+00:42:27,040 --> 00:42:31,460
+تسوينا إشي بيسموه توسع القطبات تسمى Bronchiectasis
+
+410
+00:42:31,460 --> 00:42:38,620
+وفي عندي فشل الـGI tract بما فيها الـPancreatic
+
+411
+00:42:38,620 --> 00:42:43,380
+Insufficiency طبعاً الـPancreas غير إنه Endocrine
+
+412
+00:42:43,380 --> 00:42:51,670
+تشتغل Exocrineوبعطينا هرمونات، يعني إنزيمات وبيفرز
+
+413
+00:42:51,670 --> 00:42:56,030
+باي كاربو وبيعمل كده وبيعمل كده فبصير عندي
+
+414
+00:42:56,030 --> 00:43:00,570
+«malabsorption» اللي بيسموها «ستاتورية» يعني اللي
+
+415
+00:43:00,570 --> 00:43:06,870
+هو إنه بالذات
+
+416
+00:43:06,870 --> 00:43:12,450
+الدهون لا يتم انتصاصها بشكل طبيعي فبتظلها بالقناة
+
+417
+00:43:12,450 --> 00:43:20,220
+الهضمية وبتخرج مع الدراجةفبصير البراز حجم القطعة
+
+418
+00:43:20,220 --> 00:43:25,240
+تبعته كبيرة إذا عند الواحد حمام فرنجي تظلها طافي
+
+419
+00:43:25,240 --> 00:43:30,500
+فوق، تنزلش تحت فبالتالي، difficult to flush وبتصير
+
+420
+00:43:30,500 --> 00:43:37,160
+foul smelling وبتكون فيه مشكلة فهدولة من الأمراض
+
+421
+00:43:37,160 --> 00:43:42,520
+طبعاً معاها بصير الـFat Tulip الـVitamin
+
+422
+00:43:42,520 --> 00:43:48,250
+Deficiencyاللي هم A، D وE وK، وكلها بيصير عندنا
+
+423
+00:43:48,250 --> 00:43:53,630
+مشكلة، ماشي؟ الـB والـC هم الـWater-soluble
+
+424
+00:43:53,630 --> 00:43:58,990
+vitamins، فدول ما فيهم مشكلة، ما بتم انتصاصهم مع
+
+425
+00:43:58,990 --> 00:44:02,210
+انتصاص الفات، فالـPancreatic Insufficiency
+
+426
+00:44:02,210 --> 00:44:07,390
+والتتورية والـMalabsorption فهتخرب انتصاص الفات
+
+427
+00:44:07,390 --> 00:44:10,990
+الـSoluble Vitamins، فبيصير عندى deficiency لكل
+
+428
+00:44:10,990 --> 00:44:16,220
+أشياءوBiliary Cirrhosis وLiver Disease Meconium
+
+429
+00:44:16,220 --> 00:44:20,400
+Elias الميكونيوم
+
+430
+00:44:20,400 --> 00:44:29,460
+هو الـ Brass تبع الـ Newborn يعني
+
+431
+00:44:29,460 --> 00:44:34,620
+من كثر لأنه الملوحة زايدة في الـ Secretions وفي
+
+432
+00:44:34,620 --> 00:44:39,450
+الـ GI Tractsومش قادر الواحد ينظم أو الجهاز ينظم
+
+433
+00:44:39,450 --> 00:44:44,270
+نفسه الـ Brass في الـ Newborn بيصير يابس كتير
+
+434
+00:44:44,270 --> 00:44:49,790
+وبنتيجته أنه بيسبب نوع من شلل الأمعان في حيث أنه
+
+435
+00:44:49,790 --> 00:44:55,590
+بيبطل تمشي فبيصير الـ Meconium alias الـ Newborn
+
+436
+00:44:55,590 --> 00:44:59,870
+من الأشياء اللي شو اسمها كمان بتصير عندهم
+
+437
+00:44:59,870 --> 00:45:07,670
+Infertility وتكون Subfertility in womenماشي بيكون
+
+438
+00:45:07,670 --> 00:45:15,090
+نتيجة يعني defects في نتيجة الـGene هذا وفيه عندنا
+
+439
+00:45:15,090 --> 00:45:18,670
+nasal polyps و clubbing on the nails أدول
+
+440
+00:45:18,670 --> 00:45:23,630
+الـCommon فهو هنا الـTreatment symptomatic يعني
+
+441
+00:45:23,630 --> 00:45:32,470
+بنحط شو اسمه؟ طبعاً الـNail
+
+442
+00:45:32,470 --> 00:45:35,680
+clubbingاللي هي ظاهرة الـ clubbing على الـ fingers
+
+443
+00:45:35,680 --> 00:45:39,180
+جزء أهم أساس أساسها الـ recurrent infection
+
+444
+00:45:39,180 --> 00:45:42,540
+والبرونكياكتسس البرونكياكتسس with or without
+
+445
+00:45:42,540 --> 00:45:47,420
+cystic fibrosis راح تخلي فيه clubbing وبعدين أنا
+
+446
+00:45:47,420 --> 00:45:50,900
+بحاول أساعد المريضة بفعله chest physical therapy
+
+447
+00:45:50,900 --> 00:45:57,400
+بعطيه bronchodilator بحط عشان أدوب الـ mucus لأنه
+
+448
+00:45:57,400 --> 00:46:02,540
+thick و very thick بسموها الـDNAيعني عبارة عن
+
+449
+00:46:02,540 --> 00:46:07,820
+enzyme aerosolized يعني بيحطوه بالنفس عشان يعني
+
+450
+00:46:07,820 --> 00:46:11,820
+يذوب الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+451
+00:46:11,820 --> 00:46:12,160
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+452
+00:46:12,160 --> 00:46:13,360
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+453
+00:46:13,360 --> 00:46:14,220
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+454
+00:46:14,220 --> 00:46:15,000
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+455
+00:46:15,000 --> 00:46:17,020
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+456
+00:46:17,020 --> 00:46:19,200
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+457
+00:46:19,200 --> 00:46:23,720
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+458
+00:46:23,720 --> 00:46:28,300
+الـ
+
+459
+00:46:28,300 --> 00:46:35,120
+الـ الماشي، هذا المرض الأول، شو اللي بعده؟ إذا في
+
+460
+00:46:35,120 --> 00:46:39,140
+أسئلة، يعني هذا Cystic Fibrosis موجود في كتابكم،
+
+461
+00:46:39,140 --> 00:46:44,780
+موجود هنا، كده، ماشي، بقى وهذه اللي اسمها Extinct
+
+462
+00:46:44,780 --> 00:46:51,240
+Recessive Disorder، ماشي، آسف، اللي احنا دي Autism
+
+463
+00:46:51,240 --> 00:46:56,480
+Recessive اللي إيه Cystic Fibrosisهنا حاطين شو
+
+464
+00:46:56,480 --> 00:47:03,860
+اسمه Extinct Recesses ماشي بيه مرض الـ Duchenne
+
+465
+00:47:03,860 --> 00:47:13,880
+Dystrophy هذا نعم الـ Duchenne شو اسمه فيه عبارة
+
+466
+00:47:13,880 --> 00:47:23,530
+عن جيل مسئول عنالـ «بروتين» الـ «ديستروفين» هذا هو
+
+467
+00:47:23,530 --> 00:47:31,490
+بروتين موجود في الـ الـ «موسلز» عشان الـ «أكتين»
+
+468
+00:47:31,490 --> 00:47:35,770
+والـ «مايوسين» اللي هم البروتينات اللي بتعمل الـ
+
+469
+00:47:35,770 --> 00:47:41,970
+«موسلز» وبتخلّي الـ «موسلز» تشتغل، ماشي خربا، في
+
+470
+00:47:41,970 --> 00:47:44,330
+مشكلة، ماشي
+
+471
+00:47:45,940 --> 00:47:50,660
+فبالنهاية بيأثر على الـ Intracellular Cytoskeleton
+
+472
+00:47:50,660 --> 00:47:57,180
+اللي هو الـ Actin ناشي؟ وفيه له أكثر من شغل فالآن
+
+473
+00:47:57,180 --> 00:48:05,200
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+474
+00:48:05,200 --> 00:48:05,220
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+475
+00:48:05,220 --> 00:48:05,360
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+476
+00:48:05,360 --> 00:48:05,940
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+477
+00:48:05,940 --> 00:48:08,640
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+478
+00:48:08,640 --> 00:48:08,640
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+479
+00:48:08,640 --> 00:48:08,640
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+480
+00:48:08,640 --> 00:48:19,400
+الـ الـ الـ الـوهو مسئول عن الـ «دستروفين»، ماشي؟
+
+481
+00:48:19,400 --> 00:48:24,120
+وهذه حاطينة كتدوشين هو «deleted distrophin» يعني
+
+482
+00:48:24,120 --> 00:48:28,320
+الـ «دستروفين» اللي هو البروتين اللازم لوظيفة
+
+483
+00:48:28,320 --> 00:48:35,560
+العضلات مفقود وكون صار له «deletion»، ماشي؟ الآن
+
+484
+00:48:35,560 --> 00:48:41,620
+بالنسبة لمثل هيك مرض الـ
+
+485
+00:48:43,000 --> 00:48:51,260
+في عدة ضواحب النقطة الأولى ماشية بالأخير
+
+486
+00:48:51,260 --> 00:48:56,600
+هو فيه muscle weakness يعني الطفل ما يقعدش طبعاً
+
+487
+00:48:56,600 --> 00:49:02,600
+الدشين اللي هو النوعية الشديدة منه فيه issue اسمه
+
+488
+00:49:02,600 --> 00:49:11,220
+بكر muscular dystrophy البكر نفس الدشين بس الدشين
+
+489
+00:49:11,220 --> 00:49:20,190
+أشدوببين من الطفولة وبطولش البكر بيجي بعدين يعني
+
+490
+00:49:20,190 --> 00:49:26,090
+بيظهر مثلا يعني الدوشين مستحيل تقريبا يوصلوا فوق
+
+491
+00:49:26,090 --> 00:49:34,430
+الـ 12 ثانية يعني شو اسمه؟ راح يكونوا يعني يموتوا
+
+492
+00:49:34,430 --> 00:49:39,220
+بشكل مبكروأهم محل اللي بتخرب فيه العضلات الرياتين
+
+493
+00:49:39,220 --> 00:49:44,120
+أو العضلات التنفسية أو على الوقوف ولا الماشي ولا
+
+494
+00:49:44,120 --> 00:49:50,760
+كده فـ «دوشين» أشد وبيخلق .. بي .. بيموتوا بسرعة
+
+495
+00:49:50,760 --> 00:50:01,380
+فيه والد يعني الفكر أخر وبيبدأ متأخر وبيطوله أكتر
+
+496
+00:50:01,380 --> 00:50:11,330
+ماشيالآن الـ Duchene نتيجة خراب الـ الـ الـ الـ
+
+497
+00:50:11,330 --> 00:50:16,230
+muscle protein الـ الـ motor development بتصير
+
+498
+00:50:16,230 --> 00:50:22,590
+ضعيفة يعني بتطلع بـ طبعاً جزء منه بنقول pseudo
+
+499
+00:50:22,590 --> 00:50:28,670
+hypertrophy يعني إيش؟ اللي هي يعني hypertrophy
+
+500
+00:50:28,670 --> 00:50:35,200
+تدخم بس هاي تدخم كابتيعني إذا إنسان طبيعي بيروح
+
+501
+00:50:35,200 --> 00:50:41,080
+بيجيب عضلات وثبات بيصير يحرك في عضلاته ويمرّن نفسه
+
+502
+00:50:41,080 --> 00:50:47,380
+ويقويها العضلات بتتضخم وتكبر تستجيب للتمرين فهي
+
+503
+00:50:47,380 --> 00:50:52,780
+true hypertrophy ماشي، بتكون عضلات الواحد هي قوية
+
+504
+00:50:52,780 --> 00:50:58,760
+أما اللي عنده الدوشين بيكون شكل العضلات الكبير بس
+
+505
+00:50:58,760 --> 00:51:03,060
+هي عضلات ضعيفة عشان هي بتسميها pseudo hypertrophy
+
+506
+00:51:03,550 --> 00:51:12,830
+فأنا في صورة عندكم بالكتاب اللي هو «تومسون» بيحطين
+
+507
+00:51:12,830 --> 00:51:18,990
+هيك بطة واحد وهيك كبيرة بس ضعيفة، ناشي؟ فهي بدنا
+
+508
+00:51:18,990 --> 00:51:23,470
+نقولها «Calve pseudo-hypertensive» الـ«إش» التاني
+
+509
+00:51:23,470 --> 00:51:27,930
+لديه شيء Characteristic اللي هو «Goers sign» اللي
+
+510
+00:51:27,930 --> 00:51:34,530
+هو حاطينكم إياها هنا، إنه الطفلأو الإنسان هذا لما
+
+511
+00:51:34,530 --> 00:51:42,930
+ترفعها شويه لما بده يوقف ماشي لما بده يوقف كأنه
+
+512
+00:51:42,930 --> 00:51:50,050
+بتسلك على حاله يعني بكون نايم على ظهره بده يحاول
+
+513
+00:51:50,050 --> 00:51:56,970
+يوقف فشو بعمل؟ بكون نايم على ظهره بالأول بقلب على
+
+514
+00:51:56,970 --> 00:52:02,930
+بطنه برفع كفاب الأول هيكوبعدين بيحاول يحمل حاله
+
+515
+00:52:02,930 --> 00:52:08,450
+بهذا الشكل وبعدين بيستخدم إيديه إنه يرتكز على
+
+516
+00:52:08,450 --> 00:52:14,950
+تخدتيه وجريه عشان يكوّم نفسه، ماشي؟ فهي اسمها
+
+517
+00:52:14,950 --> 00:52:20,150
+Gower sign اللي هو ال patient uses upper extremity
+
+518
+00:52:20,150 --> 00:52:25,430
+to help stand up يعني بتسلق على نفسه، بهذه الطريقة
+
+519
+00:52:25,430 --> 00:52:31,340
+لما تشوف طفل أو إنسان بيوقف بهذه الطريقةهذه مع الـ
+
+520
+00:52:31,340 --> 00:52:34,960
+Muscular Disabilities مع الـ Muscle Weakness مع
+
+521
+00:52:34,960 --> 00:52:42,220
+الـ Dad «دوشين» كطفل صغير، ماشي؟ فهذه اللي اسمها
+
+522
+00:52:42,220 --> 00:52:49,120
+«جوار الصين»، ماشي الحال؟ الآن نتيجة المشاكل في
+
+523
+00:52:49,120 --> 00:52:56,270
+الـ Muscle Fibers و الـ Muscle Proteins و كدهالـ
+
+524
+00:52:56,270 --> 00:52:59,870
+«CPK» الإنزايم الخاص بـ «كرياتين» مثل «كاينيل» أو
+
+525
+00:52:59,870 --> 00:53:05,470
+«فوتبو كاينيل» بيصير مرتفع وهي كان من المظاهر إنه
+
+526
+00:53:05,470 --> 00:53:12,050
+فيه مشكلة بالنسبة للـ «مصر»،
+
+527
+00:53:12,050 --> 00:53:18,630
+ماشي؟ فالآن احنا، خلّيني نذكر شغل، هذا X-linked
+
+528
+00:53:18,630 --> 00:53:23,730
+recessive يعني الأولاد اللي بنصابه، وبروح بدور على
+
+529
+00:53:23,730 --> 00:53:29,240
+أخاهماشي باسأله عن خالق آي اللي بده تكون والـ
+
+530
+00:53:29,240 --> 00:53:36,120
+females بكونوا career ماشي ال females والله في
+
+531
+00:53:36,120 --> 00:53:44,040
+واحدة عندها طلعت دوشين وهي Turner ماشي ماعنداش غير
+
+532
+00:53:44,040 --> 00:53:49,060
+copy واحدة من ال X ممكن، ممكن تكون عندها بس بتكون
+
+533
+00:53:49,060 --> 00:53:57,560
+unusual ننزل تحت ال baker نفس ال دوشينبس بتبدأ بـ
+
+534
+00:53:57,560 --> 00:54:05,740
+يعني هي نوع أخر وبتبدأ شو اسمه؟ في مرحلة يعني
+
+535
+00:54:05,740 --> 00:54:12,260
+متأخر عنه يعني الـ «دوشين» عادة بتوفر قولنا على
+
+536
+00:54:12,260 --> 00:54:18,780
+عمر الـ 12 يعني يدوبك يدخل يكون adolescent يعني
+
+537
+00:54:18,780 --> 00:54:23,600
+مرحلة الـ Blue فالبكر نوع أخر بس من نفس المشكلة
+
+538
+00:54:24,150 --> 00:54:30,930
+وبتكون يعني الـ onset متأخر عن البكر عن الدشين
+
+539
+00:54:30,930 --> 00:54:41,950
+والمريد بعيش أكتر ماشي فيه إيش اسمه Myotonia أحنا
+
+540
+00:54:41,950 --> 00:54:50,010
+هنا يعني هدف ال course بالذات عن الـ Genetics مش
+
+541
+00:54:50,010 --> 00:54:55,460
+عن الـ Diseasesماشي، يعني هم الواحد اللي بعرف عن
+
+542
+00:54:55,460 --> 00:54:58,960
+الـ Disease بيفهم الـ Genetics أكتر صحيح وإن
+
+543
+00:54:58,960 --> 00:55:03,660
+الواحد اللي اتقرب إلها صحيح بس أنا بتوقع أنه يعني
+
+544
+00:55:03,660 --> 00:55:10,360
+خلّينا يعني نتذكر علاقة ال manifestation والعراب
+
+545
+00:55:10,360 --> 00:55:18,020
+والظواهر مع ال genes وشو دخلها البكر أخف نشيل أقوى
+
+546
+00:55:18,020 --> 00:55:29,620
+وأشد، ماشي والـ Mayotoniaهو عبارة عن حالة اللي
+
+547
+00:55:29,620 --> 00:55:38,040
+هي تعريفها إذا الواحد بتذكر الـ… الـPhysiology تبع
+
+548
+00:55:38,040 --> 00:55:43,560
+الـMuscle وكيف الـMuscle بيصير فيها Contracture
+
+549
+00:55:43,560 --> 00:55:54,390
+الـMuscle، بدك تتذكر إنه الـMuscleالـ ATP والإنرجي
+
+550
+00:55:54,390 --> 00:56:01,870
+هو في الـ phase of release يعني أنت العضلات بتلاقي
+
+551
+00:56:01,870 --> 00:56:08,550
+مثلا هذا أكتين وهذا مايوسين خيوط بتلاقيها لما بدها
+
+552
+00:56:08,550 --> 00:56:16,170
+العضلة مثلا تنقبض بفسلا عن بعض وبعدين بقصر و بقرب
+
+553
+00:56:16,170 --> 00:56:19,970
+أكتر على بعض مثلا يعني بيكون هيك بالأول بعاد عن
+
+554
+00:56:19,970 --> 00:56:24,880
+بعضالـ Energy اللي بدك إياها عشان يفكن عن بعض
+
+555
+00:56:24,880 --> 00:56:28,800
+وتقربهم بعدين على بعض يمسكوا بشكل أقوى، هيك بيصير
+
+556
+00:56:28,800 --> 00:56:35,560
+الـ Contraction فالـ Myotonia هي إن الـ muscle ما
+
+557
+00:56:35,560 --> 00:56:42,140
+فيها relaxation بتلاقي ال muscle spastic يعني شده،
+
+558
+00:56:42,140 --> 00:56:47,020
+ماشي؟ فمثلا هنا حتى هحطيه لكيا اللي هي تعريف الـ
+
+559
+00:56:47,020 --> 00:56:53,060
+Myotoniaيعني بتيجي على بني آدم بتسلم عليه بس يشد
+
+560
+00:56:53,060 --> 00:57:02,860
+إيده، بيقدرش يفلطها، هيك بتسلطيه، ماشي، شو اسمهم؟
+
+561
+00:57:02,860 --> 00:57:08,580
+بعدين هنا هو Autosomal Dominant أنا مش عارف ليش
+
+562
+00:57:08,580 --> 00:57:17,190
+حاطينا هنا اللي هو الميتونالثلاثة هدولة مسكولر
+
+563
+00:57:17,190 --> 00:57:22,910
+بيزيدي بس بكر ودوشين X-linked recesses الـ
+
+564
+00:57:22,910 --> 00:57:26,990
+«ميوتونيا» أتذكر autosomal dominance الأصل ما
+
+565
+00:57:26,990 --> 00:57:30,690
+حدفعاش معاهم بس كلهم إشي بالـ muscle يعني هاي اللي
+
+566
+00:57:30,690 --> 00:57:34,370
+بدتك تتذكرها «توبيم» والله ما نتذكر «Early balding
+
+567
+00:57:34,370 --> 00:57:41,850
+in men» يعني إذا الواحد بصلّعت سرعة يعني أو صلّعت
+
+568
+00:57:41,850 --> 00:57:48,550
+مبكروكان هذا الـ Atrophy الحالة الجانب الثالث CTG
+
+569
+00:57:48,550 --> 00:57:56,290
+وهدولة Tri-Nucleotide Repeat Expansion ماشي يمكن
+
+570
+00:57:56,290 --> 00:58:00,970
+دوشين Muscular PK بعرفش لإيش يعني إيش قريب يمكن
+
+571
+00:58:00,970 --> 00:58:08,750
+للدوشين ماشي
+
+572
+00:58:10,650 --> 00:58:17,630
+فيعني هاي الشيء بتتذكره CTG هو الـ Tri-Nucleotide
+
+573
+00:58:17,630 --> 00:58:22,350
+Repeat وفي نفس الوقت أنه الـ Myotonia بيصير معاهم
+
+574
+00:58:22,350 --> 00:58:28,350
+كترة يعني بيصير عندهم مي زرقة، مي بيضة وبيصير
+
+575
+00:58:28,350 --> 00:58:34,230
+عندهم سلع وبيصير أنه الـ Gonads بيصير هم أثروا
+
+576
+00:58:34,230 --> 00:58:40,680
+فيهم بشكل مبكر فدول كلهم مع الـMyotoniaفدولة «my
+
+577
+00:58:40,680 --> 00:58:45,820
+tone is type 1» يعني في أكتر من نوع أو كده آه،
+
+578
+00:58:45,820 --> 00:58:52,340
+كمّل، هذا «ملتون»،
+
+579
+00:58:52,340 --> 00:59:04,980
+آه، طيب، فالـ يعني، شوف، بالنسبة لأغراض انتحاركم
+
+580
+00:59:04,980 --> 00:59:12,090
+معايكثير من هذه الأمراض أنا كنت حابب أنه يعني إذا
+
+581
+00:59:12,090 --> 00:59:18,770
+أنتم ماعندكم خلفية خلفية سريرية يعني أمراض إن
+
+582
+00:59:18,770 --> 00:59:26,110
+عندكم هيكي معلومات طبية أكبر يعني مافيه داعة دخول
+
+583
+00:59:26,110 --> 00:59:29,810
+كتير في تفاصيل شو هذا المرض وشو هذا المرض وكذا
+
+584
+00:59:29,810 --> 00:59:35,600
+وهيكي بساللي مطلوب إنك انت تتذكره أو تحفظه قدر ما
+
+585
+00:59:35,600 --> 00:59:40,700
+بتكون تعرفه أكتر، بتكون أكتر اللي هي الـGenetics
+
+586
+00:59:40,700 --> 00:59:47,780
+تبعاتك، ماشي؟ يعني مثلا الـFragile X-Syndrome أو
+
+587
+00:59:47,780 --> 00:59:54,080
+Red Syndrome اللي هو الـRed هسة أنا والله ماكنت
+
+588
+00:59:54,080 --> 00:59:58,300
+عارفه من قبل أو مش بتذكره Sporadic disorder seen
+
+589
+00:59:58,300 --> 01:00:03,050
+almost exclusively in girlsالجماهير يموتون في
+
+590
+01:00:03,050 --> 01:00:07,330
+مدينة نيوترو قريبًا بعد الحفر أكثر الحالات هذه
+
+591
+01:00:07,330 --> 01:00:13,190
+ملحوظة من ميكبتين ميكبتين ميكبتين ميكبتين ميكبتين
+
+592
+01:00:13,190 --> 01:00:13,530
+ميكبتين ميكبتين ميكبتين ميكبتين ميكبتين ميكبتين
+
+593
+01:00:13,530 --> 01:00:14,330
+ميكبتين ميكبتين ميكبتين ميكبتين ميكبتين ميكبتين
+
+594
+01:00:14,330 --> 01:00:15,310
+ميكبتين ميكبتين ميكبتين ميكبتين ميكبتين ميكبتين
+
+595
+01:00:15,310 --> 01:00:22,430
+ميكبتين ميكبتين ميكبتين ميكبتين ميكبتين ميكبتين
+
+596
+01:00:22,430 --> 01:00:27,500
+ميكبتين ميكالـMotor، الـVerbal، الـCognitive
+
+597
+01:00:27,500 --> 01:00:30,280
+Abilities، الـAtaxia، الـSeizure، الـGrowth
+
+598
+01:00:30,280 --> 01:00:34,840
+Ferries، الـStereotype، الـHand Wiggling،
+
+599
+01:00:34,840 --> 01:00:38,060
+الـWringing،
+
+600
+01:00:38,060 --> 01:00:42,900
+الـRegression، ممكن يا دكتور، Fragile X Syndrome،
+
+601
+01:00:42,900 --> 01:00:46,480
+هذا يمكن كان مكرر كتير في الأسئلة، يعني إذا بتكشفش
+
+602
+01:00:46,480 --> 01:00:49,980
+رحلية الـSyndrome، فFragile X، فFragile كان ممكن
+
+603
+01:00:49,980 --> 01:00:57,030
+تكشف الـWorld، خلينا ناخدهم،اسمها regression ماشي
+
+604
+01:00:57,030 --> 01:01:03,610
+اللي هو يعني التراجع يعني احنا بالأطفال أنا مش
+
+605
+01:01:03,610 --> 01:01:08,130
+طبيب أطفال بس بالأطفال الـ milestones تبعات الطفل
+
+606
+01:01:08,130 --> 01:01:15,030
+يعني أمتى عند الولادة أو أول الولادة و بعدها على
+
+607
+01:01:15,030 --> 01:01:18,810
+أي مدة و هاي الـ 70 أطفال مسؤولين عنها و لازم يحرك
+
+608
+01:01:18,810 --> 01:01:23,640
+أمتى الطفل بيقدر يقلب على بطنهولو ما تحطه على ظهره
+
+609
+01:01:23,640 --> 01:01:27,700
+أمتى بيقدر يجلد؟ أمتى بيقدر يجول؟ أمتى بيقدر يوقف؟
+
+610
+01:01:27,700 --> 01:01:32,220
+أمتى بيقدر يمشي؟ هاي كلها motor بنسميها milestone
+
+611
+01:01:32,220 --> 01:01:36,980
+يعني مهارات
+
+612
+01:01:36,980 --> 01:01:46,700
+حركية إلها يعني تواريخ معينة لازم بشكل طبيعي الطفل
+
+613
+01:01:46,700 --> 01:01:52,060
+يكتسبها مهارات يكتسبها جديدةفلمّا يكون مثلًا طفل
+
+614
+01:01:52,060 --> 01:01:59,080
+كان يقدر يقلب، بطل، كان يقدر يقعد، بطل يقدر يقعد،
+
+615
+01:01:59,080 --> 01:02:03,200
+كان يقدر يوقف، بطل يقدر يوقف، بطل يقدر يمشي، كان
+
+616
+01:02:03,200 --> 01:02:08,920
+يقدر يركض، كان كذا، هذه كلها Motor Skills فإذا
+
+617
+01:02:08,920 --> 01:02:13,220
+فيها تراجع، نسميه Regression في نفس الوقت
+
+618
+01:02:13,220 --> 01:02:19,140
+الـVerbal يعني بدأ يحكي بابا، ماما بالأول لازم
+
+619
+01:02:19,630 --> 01:02:24,010
+وبعدين بابا وبعدين مثلا نسير يتكلم باقيت الكلمات
+
+620
+01:02:24,010 --> 01:02:29,950
+والـ Cognitive الـ Ataxia الـ Coordination تبع
+
+621
+01:02:29,950 --> 01:02:38,610
+الحركات لو حدوث تشنجات أو Growth Failure أو أنه
+
+622
+01:02:38,610 --> 01:02:42,650
+مثلا بيحرك يديه بشكل معين، هذه كلها اسمها Red
+
+623
+01:02:42,650 --> 01:02:48,570
+Syndrome أهم شي فيها أنه بيصير Regression وشو
+
+624
+01:02:48,570 --> 01:02:55,930
+اسمه؟هي اللي احنا بدنا ياه إنه X-chromosome linked
+
+625
+01:02:55,930 --> 01:03:07,250
+وشكلها dominant ماشي الـ الـ الـ males die ال
+
+626
+01:03:07,250 --> 01:03:13,490
+females بيصير عندهم المشاكل ده ماشي فهدول أي شيء
+
+627
+01:03:13,490 --> 01:03:19,480
+مهم ال X ال fragile X syndromeاللي هو X-linked
+
+628
+01:03:19,480 --> 01:03:21,880
+dominant inheritance شكله زي اللي في الـ Rett
+
+629
+01:03:21,880 --> 01:03:30,000
+Syndrome الـ Trilucotide repeat in FM-fragile أو
+
+630
+01:03:30,000 --> 01:03:35,080
+FMR1-Gene، Hypermethylation تؤدي لـ Decreased
+
+631
+01:03:35,080 --> 01:03:38,580
+aggression، most common cause of inherited
+
+632
+01:03:38,580 --> 01:03:41,080
+intellectual disability، and second most common
+
+633
+01:03:41,080 --> 01:03:44,940
+cause of genetically associated mental deficiency
+
+634
+01:03:44,940 --> 01:03:46,420
+after Down syndrome
+
+635
+01:03:50,810 --> 01:03:57,730
+الـ «high X-linked dominant inheritance» هيك اللي
+
+636
+01:03:57,730 --> 01:04:07,270
+يعني بالأخير بيقدّي لشو اسمه؟ بيقدّي لـ «mental
+
+637
+01:04:07,270 --> 01:04:14,070
+deficiency» وبيعتبروه ثاني لـ «down syndrome» الـ
+
+638
+01:04:14,070 --> 01:04:21,080
+«findings»Post-Provertial Macro-Orchidism لـ Large
+
+639
+01:04:21,080 --> 01:04:28,860
+Testicles Long Face with a Large Jaw بيصير تضخم أو
+
+640
+01:04:28,860 --> 01:04:35,120
+الفك السفلي والقلوي الكبار Large Reverted Ears
+
+641
+01:04:35,120 --> 01:04:41,760
+Autism Microvalve Prolapse يعني
+
+642
+01:04:41,760 --> 01:04:49,070
+هو سبب للتخلف العقليوهيك المظهر تنين كبار فكت كبير
+
+643
+01:04:49,070 --> 01:04:58,770
+يعني تشوّات معينة بتكون موجودة وفي FMR1 جيل بيصير
+
+644
+01:04:58,770 --> 01:05:04,270
+عنده زيادة أو insertion لتلاتيات من الـNucleotides
+
+645
+01:05:04,270 --> 01:05:09,340
+ماشي؟ وبيصير hypermetilationاللي هو جزء من الـ
+
+646
+01:05:09,340 --> 01:05:12,560
+Epigenetic Control وبعد إلى Dictated Expression
+
+647
+01:05:12,560 --> 01:05:23,020
+يعني هاي المظاهر تبعته، ماشي أنا أظن يعني تفاصيلها
+
+648
+01:05:23,020 --> 01:05:30,840
+مش مقتنع إنه راح تفيد يعني لغير قضية الدخول
+
+649
+01:05:30,840 --> 01:05:36,800
+إمتحانات الـUSA ملي والـ يعني في، إذا الواحد بيفكر
+
+650
+01:05:36,800 --> 01:05:43,050
+يسويهايعني تفاصيل الأمراض هذه مطلوبة من المتخصص
+
+651
+01:05:43,050 --> 01:05:51,070
+يعني بس كطلاب أنتم مسئولين، شو كمان يا دكتور كريم؟
+
+652
+01:05:51,070 --> 01:05:56,390
+أحسن لو أنه في أسئلة يعني هدول هيأخر موضوع الـ
+
+653
+01:05:56,390 --> 01:06:00,350
+Huntington's disease شو هميت الـ Huntington's
+
+654
+01:06:00,350 --> 01:06:07,110
+disease؟ مرض سيء، ماشي، الـ
+
+655
+01:06:08,580 --> 01:06:13,060
+بيدّي الـ… يعني إليها اسم مثلًا بيسموها
+
+656
+01:06:13,060 --> 01:06:17,560
+«Huntington Chorea» أو «Huntington Disease»
+
+657
+01:06:17,560 --> 01:06:24,460
+«Chorea» هي عبارة عن حالة حصبية، ماشي، إذا بدي
+
+658
+01:06:24,460 --> 01:06:32,740
+أجيجولة إنه بتلاقي الواحد كل شوي دا بتحرك من بلا
+
+659
+01:06:32,740 --> 01:06:41,660
+إرادة وبكون يعني مش متحكم بعضلاتهويعني المشكلة فيه
+
+660
+01:06:41,660 --> 01:06:50,060
+إنه يعني بالأخير لا بيقدر واحد يأكل أو يعني يتحرك
+
+661
+01:06:50,060 --> 01:06:55,980
+بشكل طبيعي بنتج عنه إنه الـ «شو اسمه؟» بنتج عنه
+
+662
+01:06:55,980 --> 01:07:04,340
+إنه ال .. بنتج عنه إنه بيتوفوا بشكل مبكر نال نسبية
+
+663
+01:07:04,340 --> 01:07:06,880
+بس العيب تبعه إنه
+
+664
+01:07:09,360 --> 01:07:13,560
+البداية متأخرة، أنا على سن الأربعين أو على سن
+
+665
+01:07:13,560 --> 01:07:20,060
+الخمس، أنا أقل شيء 35 لـ40، فالعيب تبعه في هذه
+
+666
+01:07:20,060 --> 01:07:25,520
+القضية أنه على سن الأربعين غالبية الناس يُعتدوا on
+
+667
+01:07:25,520 --> 01:07:29,200
+the dominant، يعني ذكور أو إنات، ويكونوا اتجوزوا
+
+668
+01:07:29,200 --> 01:07:37,830
+وخلفوا وصار عنده ناس وكذا، ماشي؟فالحالة هذه
+
+669
+01:07:37,830 --> 01:07:45,510
+المشكلة بتكون أن الولاد والبنات ده شخص مصاب بهذا
+
+670
+01:07:45,510 --> 01:07:50,730
+الاشي وفي الحالة هذه بتلاقي بيجي يركض على الأطباء
+
+671
+01:07:50,730 --> 01:07:54,870
+«شو أعمل؟» «شو أسوي؟» في ناس في دول كتير بتلاقي
+
+672
+01:07:54,870 --> 01:08:00,810
+بنتحر ولا كده ولا هيك يعني فبتلاقي فيه مشكلة
+
+673
+01:08:03,650 --> 01:08:09,090
+يعني هي إفعيلها جانب أخلاقي إنه أنت شخص بتلاقيه
+
+674
+01:08:09,090 --> 01:08:13,950
+كبير بالعمر أربعين سنة ويقولك لأن أبوه مات عمره
+
+675
+01:08:13,950 --> 01:08:20,990
+ستين أو خمس وخمسين بموت صعب بالشلل بطريقة عاشية
+
+676
+01:08:20,990 --> 01:08:26,470
+وفيها مشكلة فبيقولك طب أنا شو احتمالية أن أكون
+
+677
+01:08:26,470 --> 01:08:33,610
+حامل المرض هذا؟ فهذا المرض اتزاما الـ dominantيعني
+
+678
+01:08:33,610 --> 01:08:39,690
+فيه مشكلة وبعدين إذا هو اتزوج يمكن يأخر زواجه يمكن
+
+679
+01:08:39,690 --> 01:08:45,450
+مارضعش يخلف لأنه خايف 50% يعطي الطفل الـChance أو
+
+680
+01:08:45,450 --> 01:08:58,890
+يروح يتحصل، يعمل IVF ويسوي نوع من الدراسة لقضية هل
+
+681
+01:08:58,890 --> 01:09:06,430
+هو الجنين مصاب ولا مش مصابفكل هذه بتكون موجودة هو
+
+682
+01:09:06,430 --> 01:09:13,550
+أنا صراحة حاطينكم يعني الـ Huntington's disease
+
+683
+01:09:13,550 --> 01:09:19,190
+الـ Myotonic Dystrophy وحاطيني Fredrick's Ataxia
+
+684
+01:09:19,190 --> 01:09:23,830
+كمان رجال X-Syndrome اتكلمنا عنه برضه mental
+
+685
+01:09:23,830 --> 01:09:31,100
+deficiency ويعني بقدر تخلف عقلالـ Friedreich's
+
+686
+01:09:31,100 --> 01:09:36,940
+ataxia يعني أنا بتذكرها في الطب بتعطي مشاكل في
+
+687
+01:09:36,940 --> 01:09:45,520
+القلب بتعطي شو اسمه؟ إذا بتاخد بالعصاب Upper motor
+
+688
+01:09:45,520 --> 01:09:50,200
+neuron legion الـ Friedreich's ataxia من أسباب الـ
+
+689
+01:09:50,200 --> 01:09:54,860
+BOTH إنه في نفس الإنسان Upper motor و Lower motor
+
+690
+01:09:54,860 --> 01:10:00,380
+neuron legion في أي ناحيةالـ Upper Motor Neuron
+
+691
+01:10:00,380 --> 01:10:04,400
+Legion بيعمل Spasticity بيعمل Exaggerated Reflexes
+
+692
+01:10:04,400 --> 01:10:10,480
+بيعمل كده فالـ و العكس الـ Lower Motor Neuron
+
+693
+01:10:10,480 --> 01:10:17,060
+Legion بتعمل Flaccidity يعني هيك بتلاقي العضلات
+
+694
+01:10:17,060 --> 01:10:22,980
+رخوة زي إذا طفل أو إنسان عنده مثلا البوليو اللي هو
+
+695
+01:10:22,980 --> 01:10:31,390
+شلل الأفطار وبتلاقي Absent Reflexes وكدهأنا بتوقع،
+
+696
+01:10:31,390 --> 01:10:37,930
+بتوقع إنه الـ… الـ… هنا دولة، التلت أو أربع امراض
+
+697
+01:10:37,930 --> 01:10:42,390
+حاطين إنه الـTrinucleotide Repeat Expansion
+
+698
+01:10:42,390 --> 01:10:51,270
+Disease يعني فيه protein أو جين أو إشي بيصير الـ…
+
+699
+01:10:51,270 --> 01:10:58,330
+شو اسمه؟ بيصير تلافيات من الـ… من الـNucleotides
+
+700
+01:10:59,130 --> 01:11:05,290
+بيصير لهم insertion زيادة فالمرات
+
+701
+01:11:05,290 --> 01:11:10,930
+بتخرب وظيفة البروتين إنه كذا amino acid أو كذا إشي
+
+702
+01:11:10,930 --> 01:11:17,030
+بالحق مش المفروض يكون محتوى، بس يعني مرتبط بكمية
+
+703
+01:11:17,030 --> 01:11:21,430
+يعني مش زي الـsickle cell إنه one nucleotide اللي
+
+704
+01:11:21,430 --> 01:11:28,090
+متغير سبب مرض، فالـrepeats هو أنا حاطينها بالـN
+
+705
+01:11:29,560 --> 01:11:35,520
+رابطين كل مرض بـ «كاج»
+
+706
+01:11:35,520 --> 01:11:39,300
+«كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج»
+
+707
+01:11:39,300 --> 01:11:41,460
+«كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج»
+
+708
+01:11:41,460 --> 01:11:44,640
+«كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج»
+
+709
+01:11:44,640 --> 01:11:44,800
+«كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج»
+
+710
+01:11:44,800 --> 01:11:46,820
+«كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج»
+
+711
+01:11:46,820 --> 01:11:55,940
+«كج» «كج» «كج
+
+712
+01:11:57,060 --> 01:12:01,580
+يعني أنا من الأشياء اللي شُفتها وقلتلكم ان تتبعوا
+
+713
+01:12:01,580 --> 01:12:07,840
+عليها اللي هي الـ Stop-on Codon تبع الـ… تبع الـ…
+
+714
+01:12:07,840 --> 01:12:12,940
+الـTriplets دولة تبع الـTri-Nucleotides لما نتيجي
+
+715
+01:12:12,940 --> 01:12:18,000
+تلاتة اللي بيقشروا على إنه أي Stop فيه ثلاث
+
+716
+01:12:18,000 --> 01:12:25,380
+Repeats من الـ64 possible triplets،
+
+717
+01:12:25,380 --> 01:12:33,180
+ماشي؟فهذولا الـ… يعني حتى هنا بيحاولوا يساعدوكم
+
+718
+01:12:33,180 --> 01:12:39,000
+إنه يعطيكم الـMnemonics تبعتها كيف تربطها وهي في
+
+719
+01:12:39,000 --> 01:12:43,400
+الطب ضرورية يعني
+
+720
+01:12:43,400 --> 01:12:47,140
+الـTry
+
+721
+01:12:47,140 --> 01:12:52,960
+nucleotide أنا بحاول أشوف «Try hunting for my
+
+722
+01:12:52,960 --> 01:13:01,620
+fragile cage-free egg»X يعني هاي كلمات يعني هاي
+
+723
+01:13:01,620 --> 01:13:07,400
+أسلوب إذا بتلاقوا إشي وحاولوا تحفظوها بتفيد، بتفيد
+
+724
+01:13:07,400 --> 01:13:13,100
+يعني أنا مثلا كنت بالـAnatomy شاطر الـAnatomy كنا
+
+725
+01:13:13,100 --> 01:13:16,220
+الله يرضى عليهم أساتفنا أو بكتير من المصريين
+
+726
+01:13:16,220 --> 01:13:22,240
+يحاولوا يحفظونا الأشياء تحتهم فكان مثلا شو أسماء
+
+727
+01:13:22,240 --> 01:13:29,800
+عظام الـAnkle والله صعببس كان فيه دكتور الله يرفع
+
+728
+01:13:29,800 --> 01:13:34,460
+عليه ويرحمه الآن يقول تفيدة كلت كشري ناشف و تلت
+
+729
+01:13:34,460 --> 01:13:42,400
+كتاكيد تاليوس، كالكانيوس، كونيفورم، نيوبفورم، مش
+
+730
+01:13:42,400 --> 01:13:45,900
+عارف إيش بس هي يعني الـ… الـ… الـ… الـMnemonic
+
+731
+01:13:45,900 --> 01:13:52,720
+تبعها طريقة الحفظ هذه مفيدة وكويسة فاللي حاطينه
+
+732
+01:13:52,720 --> 01:14:01,260
+لكميا عليه أحمر، كويسTri-Nucleotide Hunting for My
+
+733
+01:14:01,260 --> 01:14:12,520
+Fragile Cage-Free Eggs My Tonic
+
+734
+01:14:12,520 --> 01:14:21,100
+Hunting يعني الـ Tri-Nucleotide Hunting اللي هي
+
+735
+01:14:21,100 --> 01:14:28,720
+Hunting في كوريا أو Diseaseاللي هي Myotonia cage
+
+736
+01:14:28,720 --> 01:14:35,540
+-free اللي هي fragile X و fragile يمكن Fredericks
+
+737
+01:14:35,540 --> 01:14:43,360
+ماشي أو fragile لتنتين free اللي هي fragile أو
+
+738
+01:14:43,360 --> 01:14:52,200
+free مش عارف free Fredericks يعني فهذه جزء يعني
+
+739
+01:14:53,910 --> 01:14:58,090
+للإبتحانات الـ USMLE كويس الواحد ينتبه لها إن
+
+740
+01:14:58,090 --> 01:15:01,410
+هدولة أربع أمراض الـ Tri-Nucleotide Repeat
+
+741
+01:15:01,410 --> 01:15:07,130
+Expansion Diseases وهدولة الأمثلة تبعتها، كويسة،
+
+742
+01:15:07,130 --> 01:15:10,990
+يعني تستفيدوا منها إن شاء الله إذا الواحد بيقدر
+
+743
+01:15:10,990 --> 01:15:16,550
+يحفظ الـ الـ شو هي ال repeat تبعت كل مرض يمكن إن
+
+744
+01:15:16,550 --> 01:15:20,810
+شاء الله بتجيب نسب عالة و أحسن وشكلها مركزين عليه
+
+745
+01:15:22,890 --> 01:15:28,250
+الملاحظ الـ «هانتنغتون» والـ «مايتونيا» أتزامة
+
+746
+01:15:28,250 --> 01:15:32,390
+dominant رجال الـ X-syndrome X-linked dominant X
+
+747
+01:15:32,390 --> 01:15:36,330
+-linked dominant الـ «فريدريكس أتاكسيا» أتزامة
+
+748
+01:15:36,330 --> 01:15:45,730
+recessive يعني AI مهمة بدي أحفظ لخياهم شو الـ
+
+749
+01:15:45,730 --> 01:15:49,870
+trionucleotides «فريدريكس أتاكسيا» attacks الـgate
+
+750
+01:15:51,270 --> 01:16:00,270
+فـ «GAA» حاططها ماشي «Fragile Eggs» «Shin» حكينا
+
+751
+01:16:00,270 --> 01:16:06,890
+الفك كبير «Giant Gonads» الـ «Macro-Orchidism»
+
+752
+01:16:06,890 --> 01:16:13,250
+يعني التستيكلز كبار فهنا «CGG»
+
+753
+01:16:13,250 --> 01:16:18,850
+«Myotonia» الـ «Cataract» «Tope» يعني الـ «Tope»
+
+754
+01:16:18,850 --> 01:16:24,500
+أظن دكرتها الآناللي هي قطعة الشعر المستعار اللي
+
+755
+01:16:24,500 --> 01:16:31,840
+يبقى عنده صلع أو مستحيل منه مثل أبيه بيجيب ذات
+
+756
+01:16:31,840 --> 01:16:36,720
+زلام مرات بيخطوها وقنادة الـ Atrophy الـ
+
+757
+01:16:36,720 --> 01:16:40,900
+Huntington Disease الـ Caudate Nucleus عيب الـ
+
+758
+01:16:40,900 --> 01:16:48,930
+Brain مافيش فيها Acetylcholine ولا الجابااللي هو
+
+759
+01:16:48,930 --> 01:16:59,070
+الـ Neurotransmitters فكوديت أسيتالكولين جابها CAG
+
+760
+01:16:59,070 --> 01:17:10,290
+وهي Cataract وTop T وGonadal Atrophy CTG وهيك يعني
+
+761
+01:17:10,290 --> 01:17:12,930
+أنا
+
+762
+01:17:16,650 --> 01:17:22,290
+أحنا يوم الأربعة ممكن نكمل، ماشي أنا أسا عندى
+
+763
+01:17:22,290 --> 01:17:28,070
+تدريس تانى وبضطر أترككم هلأ، ماشي إذا حد عنده
+
+764
+01:17:28,070 --> 01:17:35,470
+أسئلة يحط على group medical genetics وإن شاء الله
+
+765
+01:17:35,470 --> 01:17:39,990
+يوم الأربعة بنكمل، ماشي الله يوفقكم
+
+766
+01:17:43,570 --> 01:17:46,470
+تمام يا دكتور، يعطيك العافية أهلا وسهلا، يالا
+
+767
+01:17:46,470 --> 01:17:48,210
+السلام عليكم السلام عليكم
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/vL1zB0LyhmE_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/vL1zB0LyhmE_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..b49f04418050880fad29a3b4e4cbd0b6267a72e1
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/vL1zB0LyhmE_raw.json
@@ -0,0 +1 @@
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0.802734375}, {"start": 1114.5, "end": 1115.22, "word": "%", "probability": 0.9697265625}, {"start": 1115.22, "end": 1115.96, "word": " تقريبًا", "probability": 0.9055989583333334}, {"start": 1115.96, "end": 1116.5, "word": " عندهم", "probability": 0.977294921875}, {"start": 1116.5, "end": 1116.76, "word": " one", "probability": 0.78369140625}, {"start": 1116.76, "end": 1117.44, "word": " mutation", "probability": 0.97802734375}, {"start": 1117.44, "end": 1118.56, "word": " واحد", "probability": 0.6746826171875}, {"start": 1118.56, "end": 1119.14, "word": " بالمية", "probability": 0.7737630208333334}], "temperature": 1.0}, {"id": 43, "seek": 113509, "start": 1119.72, "end": 1135.1, "text": "عندهم اللي هو الـ Double Mutations وهي الأليل وهي اسمها Derived Frequencies الأليل الفكرة من هنا", "tokens": [3615, 41260, 16095, 13672, 1829, 31439, 2423, 39184, 16633, 18517, 763, 37037, 1829, 16247, 20292, 1211, 37037, 1829, 24525, 2304, 11296, 5618, 3194, 6142, 358, 6464, 16247, 20292, 1211, 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نسبة حدوث لما ركزوا على إنهم يهتموا بهذا النوع من الـGene Mutation", "tokens": [3555, 15042, 8978, 3224, 2423, 39184, 9480, 313, 6055, 3555, 34268, 11296, 12399, 20328, 5016, 22807, 2423, 39184, 1260, 34105, 2423, 39184, 40848, 1328, 12630, 49, 20, 5551, 20292, 1211, 198, 259, 3683, 39872, 10682, 294, 3315, 4032, 44, 327, 2285, 6747, 4032, 21790, 952, 1422, 9000, 11058, 8978, 5551, 15042, 19452, 8978, 18863, 45340, 31767, 13063, 3660, 39627, 15730, 25124, 28820, 39894, 9778, 23942, 36145, 3224, 8717, 35457, 3660, 11331, 3215, 2407, 12984, 5296, 15042, 12602, 4117, 11622, 14407, 15844, 36145, 16095, 7251, 3224, 39237, 14407, 39627, 15730, 28239, 45367, 9154, 2423, 39184, 38, 1450, 376, 11380], "avg_logprob": -0.22301136423843076, "compression_ratio": 1.4022988505747127, "no_speech_prob": 3.5762786865234375e-07, "words": [{"start": 1992.53, "end": 1992.85, "word": "بما", "probability": 0.90283203125}, {"start": 1992.85, "end": 1993.19, "word": " فيه", "probability": 0.9248046875}, 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إنه هذا الآن على نموذج افتراضي اللي هو الـ Hardy-Weinberg Law وبكون إنه population stable population مافيش فيها migration مافيش فيها new mutation الـ mating أو الزواج مفتوح", "tokens": [2407, 28820, 19446, 25961, 2655, 8717, 35457, 47395, 5551, 4117, 26890, 12399, 13412, 2407, 24525, 2304, 3224, 22807, 39894, 30544, 16247, 2304, 13063, 39627, 15730, 25124, 28820, 4724, 3794, 4724, 16254, 5551, 8848, 37983, 36145, 3224, 23758, 6024, 48506, 15844, 8717, 2304, 2407, 8848, 7435, 1975, 5172, 2655, 2288, 46958, 1829, 13672, 1829, 31439, 2423, 39184, 43930, 12, 4360, 259, 6873, 7744, 46599, 30544, 36145, 3224, 4415, 8351, 4415, 19446, 41185, 8592, 8978, 11296, 17011, 19446, 41185, 8592, 8978, 11296, 777, 27960, 2423, 39184, 49955, 34051, 6024, 110, 2407, 26108, 3714, 5172, 2655, 2407, 5016], "avg_logprob": -0.16829427176465592, "compression_ratio": 1.55, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 2048.17, "end": 2049.01, "word": "وكل", "probability": 0.814697265625}, 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capital", "probability": 0.72265625}, {"start": 2512.81, "end": 2513.39, "word": " إذا", "probability": 0.919677734375}, {"start": 2513.39, "end": 2513.83, "word": " تضرب", "probability": 0.93798828125}, {"start": 2513.83, "end": 2514.43, "word": " P", "probability": 0.341796875}, {"start": 2514.43, "end": 2515.59, "word": " تربيع", "probability": 0.8355712890625}], "temperature": 1.0}, {"id": 96, "seek": 254442, "start": 2516.8, "end": 2544.42, "text": "وهذه P تربية فالاحتمالية لـ Frequency تبعت الـ AA والـ Offspring كلهم راح يكونوا Capital A Capital A راح يكونوا بهذا الشكل ماشي فإذا بتاخدها population معينة راح تلاقي نسبتهم في ال population P تقعيد أو قصر أربعة راح تلاقيها بهذا الشكل يعني", "tokens": [2407, 3224, 24192, 430, 6055, 25513, 10632, 6156, 6027, 995, 33753, 2304, 6027, 10632, 5296, 39184, 6142, 48154, 6055, 3555, 34268, 2423, 39184, 30680, 16070, 39184, 6318, 30757, 28242, 16095, 12602, 39319, 7251, 30544, 14407, 21502, 316, 21502, 316, 12602, 39319, 7251, 30544, 14407, 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{"start": 2522.0, "end": 2522.54, "word": " تبعت", "probability": 0.6392415364583334}, {"start": 2522.54, "end": 2522.9, "word": " الـ", "probability": 0.910888671875}, {"start": 2522.9, "end": 2523.3, "word": " AA", "probability": 0.5595703125}, {"start": 2523.3, "end": 2523.98, "word": " والـ", "probability": 0.5487060546875}, {"start": 2523.98, "end": 2524.5, "word": " Offspring", "probability": 0.6904296875}, {"start": 2524.5, "end": 2524.94, "word": " كلهم", "probability": 0.919677734375}, {"start": 2524.94, "end": 2525.1, "word": " راح", "probability": 0.906494140625}, {"start": 2525.1, "end": 2525.52, "word": " يكونوا", "probability": 0.9905598958333334}, {"start": 2525.52, "end": 2525.88, "word": " Capital", "probability": 0.238525390625}, {"start": 2525.88, "end": 2526.18, "word": " A", "probability": 0.95263671875}, {"start": 2526.18, "end": 2526.44, "word": " Capital", "probability": 0.232421875}, {"start": 2526.44, "end": 2526.98, "word": " A", "probability": 0.8603515625}, 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"end": 2545.88, "word": "%", "probability": 0.5732421875}, {"start": 2545.88, "end": 2546.12, "word": " في", "probability": 0.50830078125}, {"start": 2546.12, "end": 2546.4, "word": " 90", "probability": 0.9326171875}, {"start": 2546.4, "end": 2546.92, "word": "%", "probability": 0.96142578125}, {"start": 2546.92, "end": 2547.34, "word": " في", "probability": 0.54443359375}, {"start": 2547.34, "end": 2547.82, "word": " Ipoint", "probability": 0.2943115234375}, {"start": 2547.82, "end": 2548.46, "word": " 81", "probability": 0.80908203125}, {"start": 2548.46, "end": 2549.14, "word": " في", "probability": 0.81005859375}, {"start": 2549.14, "end": 2549.46, "word": " Ipoint", "probability": 0.847412109375}, {"start": 2549.46, "end": 2550.04, "word": " 81", "probability": 0.98876953125}, {"start": 2550.04, "end": 2550.42, "word": " راح", "probability": 0.575927734375}, {"start": 2550.42, "end": 2550.78, "word": " يطلع", "probability": 0.98291015625}, {"start": 2550.78, "end": 2551.34, 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{"start": 3468.13, "end": 3468.25, "word": " في", "probability": 0.59619140625}, {"start": 3468.25, "end": 3468.51, "word": " حد", "probability": 0.795166015625}, {"start": 3468.51, "end": 3468.87, "word": " بيقدر", "probability": 0.74554443359375}, {"start": 3468.87, "end": 3469.43, "word": " يقوللي؟", "probability": 0.8829345703125}], "temperature": 1.0}, {"id": 130, "seek": 351322, "start": 3486.38, "end": 3513.22, "text": "الـ على افتراض أنه هذا الـ يعني النقطة اللي بده يصلها في الموضوع هذا اللي هي موضوع أن حدوث هذه الطفرة بهذا الشكل وتواجدها في الإنسان بيكون أحيانًا lethal type يعني", "tokens": [6027, 39184, 15844, 1975, 5172, 2655, 2288, 46958, 14739, 3224, 23758, 2423, 39184, 37495, 22653, 28239, 47432, 3660, 13672, 1829, 47525, 3224, 7251, 36520, 11296, 8978, 9673, 2407, 11242, 45367, 23758, 13672, 1829, 39896, 3714, 2407, 11242, 45367, 14739, 11331, 3215, 2407, 12984, 29538, 41950, 5172, 25720, 39627, 15730, 25124, 28820, 34683, 2407, 26108, 3215, 11296, 8978, 33688, 1863, 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3495.16, "word": " بده", "probability": 0.623046875}, {"start": 3495.16, "end": 3495.72, "word": " يصلها", "probability": 0.8873697916666666}, {"start": 3495.72, "end": 3495.96, "word": " في", "probability": 0.974609375}, {"start": 3495.96, "end": 3496.76, "word": " الموضوع", "probability": 0.9276123046875}, {"start": 3496.76, "end": 3497.18, "word": " هذا", "probability": 0.97998046875}, {"start": 3497.18, "end": 3498.52, "word": " اللي", "probability": 0.943115234375}, {"start": 3498.52, "end": 3498.9, "word": " هي", "probability": 0.947265625}, {"start": 3498.9, "end": 3499.88, "word": " موضوع", "probability": 0.9686279296875}, {"start": 3499.88, "end": 3500.84, "word": " أن", "probability": 0.640625}, {"start": 3500.84, "end": 3501.64, "word": " حدوث", "probability": 0.9677734375}, {"start": 3501.64, "end": 3503.04, "word": " هذه", "probability": 0.476318359375}, {"start": 3503.04, "end": 3503.66, "word": " الطفرة", "probability": 0.9401041666666666}, {"start": 3503.66, "end": 3504.76, "word": " بهذا", "probability": 0.865478515625}, {"start": 3504.76, "end": 3505.36, "word": " الشكل", "probability": 0.9921875}, {"start": 3505.36, "end": 3506.66, "word": " وتواجدها", "probability": 0.80625}, {"start": 3506.66, "end": 3506.94, "word": " في", "probability": 0.9951171875}, {"start": 3506.94, "end": 3507.9, "word": " الإنسان", "probability": 0.99072265625}, {"start": 3507.9, "end": 3509.76, "word": " بيكون", "probability": 0.8780924479166666}, {"start": 3509.76, "end": 3511.24, "word": " أحيانًا", "probability": 0.975341796875}, {"start": 3511.24, "end": 3511.94, "word": " lethal", "probability": 0.43994140625}, {"start": 3511.94, "end": 3512.7, "word": " type", "probability": 0.857421875}, {"start": 3512.7, "end": 3513.22, "word": " يعني", "probability": 0.877197265625}], "temperature": 1.0}, {"id": 131, "seek": 354279, "start": 3513.69, "end": 3542.79, "text": "ويكون مميت فالاستنتاج من أن هذه الأمراض عبارة عن أمراض قاتلة خصوصًا أحيانًا كثيرة زي الـ Chromosome 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"probability": 0.8515625}, {"start": 3557.7, "end": 3558.54, "word": " يتزوج", "probability": 0.99072265625}, {"start": 3558.54, "end": 3559.12, "word": " بحيث", "probability": 0.85845947265625}, {"start": 3559.12, "end": 3559.94, "word": " يعطي،", "probability": 0.755126953125}, {"start": 3559.94, "end": 3560.3, "word": " ينقل", "probability": 0.984375}, {"start": 3560.3, "end": 3560.54, "word": " هذا", "probability": 0.9599609375}, {"start": 3560.54, "end": 3560.94, "word": " المرض", "probability": 0.9931640625}, {"start": 3560.94, "end": 3561.78, "word": " للأبناء", "probability": 0.91376953125}, {"start": 3561.78, "end": 3562.3, "word": " والبنات", "probability": 0.7825927734375}, {"start": 3562.3, "end": 3563.22, "word": " تبعيه", "probability": 0.864453125}, {"start": 3563.22, "end": 3564.38, "word": " فالـFrequency", "probability": 0.764697265625}, {"start": 3564.38, "end": 3564.6, "word": " اللي", "probability": 0.97900390625}, {"start": 3564.6, "end": 3564.98, "word": " 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{"start": 4151.31, "end": 4151.85, "word": " ضعف", "probability": 0.9475911458333334}, {"start": 4151.85, "end": 4152.85, "word": " فرق", "probability": 0.9728190104166666}, {"start": 4152.85, "end": 4153.83, "word": " بالنسبة", "probability": 0.8419189453125}, {"start": 4153.83, "end": 4154.21, "word": " لـ", "probability": 0.72412109375}, {"start": 4154.21, "end": 4154.65, "word": " Sickle", "probability": 0.936767578125}, {"start": 4154.65, "end": 4154.83, "word": " Cell", "probability": 0.9326171875}, {"start": 4154.83, "end": 4155.33, "word": " Anemia", "probability": 0.9755859375}, {"start": 4155.33, "end": 4155.75, "word": " بين", "probability": 0.93359375}, {"start": 4155.75, "end": 4157.03, "word": " الأفريقا", "probability": 0.80458984375}, {"start": 4157.03, "end": 4157.39, "word": " وبين", "probability": 0.809326171875}, {"start": 4157.39, "end": 4158.15, "word": " الهسباني", "probability": 0.75966796875}, {"start": 4158.15, "end": 4159.81, "word": " منينيجي", 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بعطيهم mainly Anti-D لأن أهم واحد هو الـD فلما درسوا الموضوع هذا يكون الـRh نيجاتيف للكل اللي هو واحد لسته أقل تمثل اللي هي يعني أحنا تقريباً كنا بيقول واحد لعشر", "tokens": [6027, 29973, 10721, 3660, 21542, 10943, 1211, 5296, 15042, 12602, 39319, 8717, 47283, 8848, 11296, 2423, 39184, 16111, 12, 259, 1112, 11584, 2841, 4724, 26108, 1829, 4724, 3615, 9566, 1829, 16095, 8704, 27757, 12, 35, 5296, 33456, 5551, 16095, 36764, 24401, 31439, 2423, 39184, 35, 6156, 1211, 15042, 11778, 2288, 3794, 14407, 9673, 2407, 11242, 45367, 23758, 7251, 30544, 2423, 39184, 31121, 8717, 1829, 7435, 9307, 33911, 5296, 23275, 1211, 13672, 1829, 31439, 36764, 24401, 5296, 3794, 2655, 3224, 5551, 4587, 1211, 46811, 12984, 1211, 13672, 1829, 39896, 37495, 22653, 5551, 5016, 8315, 6055, 4587, 16572, 3555, 995, 14111, 9122, 8315, 4724, 1829, 39648, 36764, 24401, 5296, 3615, 46309], "avg_logprob": -0.2931818143887953, "compression_ratio": 1.5869565217391304, "no_speech_prob": 3.635883331298828e-06, "words": 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الـ heterozygous مع بعض يعني هذه الـ frequency اللي راح أشوفها تتمثل هذه الاحتمالية فأنا لما نشوف مثلا واحد في كل 25 ألف أو واحد في كل 500 تقريبًا", "tokens": [6027, 39184, 4657, 48, 5933, 6055, 2288, 21292, 3660, 8717, 35457, 3660, 16247, 20292, 1211, 9673, 9381, 16758, 4032, 1863, 35457, 3660, 2423, 39184, 3639, 2032, 1229, 70, 563, 20449, 45030, 11242, 37495, 22653, 29538, 2423, 39184, 7893, 13672, 1829, 12602, 39319, 5551, 8592, 38688, 11296, 6055, 39237, 12984, 1211, 29538, 42963, 33753, 2304, 6027, 10632, 6156, 10721, 8315, 5296, 15042, 8717, 8592, 38688, 50113, 15040, 36764, 24401, 8978, 28242, 3552, 5551, 46538, 34051, 36764, 24401, 8978, 28242, 5923, 6055, 4587, 16572, 3555, 14111, 995], "avg_logprob": -0.1383539193937945, "compression_ratio": 1.5477386934673367, "no_speech_prob": 5.304813385009766e-06, "words": [{"start": 4469.44, "end": 4470.32, "word": "الـ", "probability": 0.950927734375}, {"start": 4470.32, "end": 4472.08, "word": " «Q»", "probability": 0.72412109375}, 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0.6923828125}, {"start": 6084.09, "end": 6084.57, "word": " سؤال", "probability": 0.9832356770833334}, {"start": 6084.57, "end": 6085.01, "word": " واضحط", "probability": 0.78887939453125}, {"start": 6085.01, "end": 6085.17, "word": " ان", "probability": 0.6435546875}, {"start": 6085.17, "end": 6085.33, "word": " شاء", "probability": 0.967041015625}, {"start": 6085.33, "end": 6085.39, "word": " الله", "probability": 0.96337890625}, {"start": 6085.39, "end": 6086.03, "word": " القضية", "probability": 0.9552408854166666}, {"start": 6086.03, "end": 6088.67, "word": " الله", "probability": 0.0726318359375}, {"start": 6088.67, "end": 6089.35, "word": " يعفوكم", "probability": 0.6685791015625}, {"start": 6089.35, "end": 6090.51, "word": " ونشوفكم", "probability": 0.88681640625}, {"start": 6090.51, "end": 6091.27, "word": " يوم", "probability": 0.973388671875}, {"start": 6091.27, "end": 6091.71, "word": " الأربع", "probability": 0.9427083333333334}, {"start": 6091.71, "end": 6091.93, "word": " ان", "probability": 0.259521484375}, {"start": 6091.93, "end": 6092.13, "word": " شاء", "probability": 0.992431640625}, {"start": 6092.13, "end": 6092.35, "word": " الله", "probability": 0.96630859375}, {"start": 6092.35, "end": 6092.99, "word": " واجهزوا", "probability": 0.81376953125}, {"start": 6092.99, "end": 6094.31, "word": " للامتحان", "probability": 0.89287109375}, {"start": 6094.31, "end": 6094.59, "word": " الله", "probability": 0.83056640625}, {"start": 6094.59, "end": 6094.97, "word": " يعفوكم", "probability": 0.9073486328125}, {"start": 6094.97, "end": 6097.99, "word": " الله", "probability": 0.1854248046875}, {"start": 6097.99, "end": 6098.25, "word": " يعفوكم", "probability": 0.9097900390625}, {"start": 6098.25, "end": 6098.31, "word": " يا", "probability": 0.45361328125}, {"start": 6098.31, "end": 6098.95, "word": " دكتور", "probability": 0.95263671875}, {"start": 6098.95, "end": 6099.59, "word": " الله", "probability": 0.7822265625}, {"start": 6099.59, "end": 6100.13, "word": " يعفوكم", "probability": 0.9739990234375}, {"start": 6100.13, "end": 6100.45, "word": " أهلا", "probability": 0.6455078125}, {"start": 6100.45, "end": 6100.79, "word": " و", "probability": 0.4697265625}, {"start": 6100.79, "end": 6100.95, "word": " أهلا", "probability": 0.9187825520833334}, {"start": 6100.95, "end": 6101.15, "word": " و", "probability": 0.43701171875}, {"start": 6101.15, "end": 6101.47, "word": " السلام", "probability": 0.85498046875}, {"start": 6101.47, "end": 6101.79, "word": " عليكم", "probability": 0.765380859375}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 6107.3356875, "duration_after_vad": 5959.58409375004}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/wEkbdETtaiE.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/wEkbdETtaiE.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ba1e77095c0735edb67e8b7619bd28954c0c9be2
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/wEkbdETtaiE.srt
@@ -0,0 +1,1878 @@
+1
+00:00:00,000 --> 00:00:07,040
+نقطة معينة الآن الصورة
+
+2
+00:00:07,040 --> 00:00:18,180
+هذه صراحة بتعقد يعني بتخربط الواحد وبتلاقي
+
+3
+00:00:18,180 --> 00:00:21,600
+لما
+
+4
+00:00:21,600 --> 00:00:27,640
+تتذكر أي فصل هي موجودة بالنسبة لـ Identify Genetic
+
+5
+00:00:27,640 --> 00:00:34,380
+Basis قدرني الرقم فاصل عشرة أتوقع هيك خلّينا نشوف
+
+6
+00:00:34,380 --> 00:00:40,660
+هنا الآن
+
+7
+00:00:40,660 --> 00:00:44,880
+اللي
+
+8
+00:00:44,880 --> 00:00:49,160
+بنحكي عنه بالنسبة لل .. لأ مش فاصل عشرة
+
+9
+00:00:55,110 --> 00:00:57,930
+على مستوى الوزارة الوزارة الوزارة الوزارة
+
+10
+00:00:57,930 --> 00:01:00,230
+الوزارة الوزارة الوزارة الوزارة الوزارة
+
+11
+00:01:00,230 --> 00:01:02,750
+الوزارة الوزارة الوزارة الوزارة الوزارة
+
+12
+00:01:02,750 --> 00:01:04,490
+الوزارة الوزارة الوزارة الوزارة الوزارة
+
+13
+00:01:04,490 --> 00:01:10,910
+الوزارة الوزارة الوزارة الوزارة
+
+14
+00:01:10,910 --> 00:01:14,550
+الوزارة الوزارة الوزارة الوزارة الوزارة
+
+15
+00:01:14,550 --> 00:01:16,310
+الوزارة الوزارة الوزارة الوزارة الوزارة
+
+16
+00:01:16,310 --> 00:01:20,470
+الوزارة
+
+17
+00:01:20,960 --> 00:01:32,500
+أنه مطلوب من الواحد يقرأ أبحاث أو يعمل
+
+18
+00:01:32,500 --> 00:01:41,150
+دراسة معينة يفهم المبدأ الـ Test اللي هو بيستخدموه
+
+19
+00:01:41,150 --> 00:01:47,910
+يعني هسة مثلاً يعني أكبر مثال الآن لو سألت معتز أنت
+
+20
+00:01:47,910 --> 00:01:52,630
+بتسمع عن الـ Corona  هذا و COVID-19 و
+
+21
+00:01:52,630 --> 00:01:59,110
+جائحة أو Pandemic يعني اشتاحت العالم كله، ماشي؟ شو
+
+22
+00:01:59,110 --> 00:02:05,030
+الـ tests اللي عندنا؟ اللي هنا؟ مفروض، الآن مفروض
+
+23
+00:02:05,410 --> 00:02:10,430
+الواحد يكون على بينة وعلم شو الأشياء اللي تستخدم
+
+24
+00:02:10,430 --> 00:02:13,670
+لما يقولوا «هذا positive، هذا negative» «ليش هذا
+
+25
+00:02:13,670 --> 00:02:17,630
+positive؟ ليش هذا negative؟» بتشكل هذا فشو أنواع
+
+26
+00:02:17,630 --> 00:02:22,390
+الـ «Tests» اللي عندنا أنت
+
+27
+00:02:22,390 --> 00:02:28,030
+حكيت كلمة اللي هي الـ «PCR»  فيهم حقيقةً ثلاث
+
+28
+00:02:28,030 --> 00:02:33,110
+أنواع من الفحوصات مش نوع واحد، وبدّك تنتبه لما
+
+29
+00:02:33,110 --> 00:02:38,730
+يقولوا إنسان طلع إيجابي أو سلبي حسب نوع الـ Test
+
+30
+00:02:38,730 --> 00:02:44,950
+اللي استخدمه فالآن اللي لو أخدنا مثال الـ Corona
+
+31
+00:02:44,950 --> 00:02:55,010
+الـ Corona بتلاقوا ثواني، آه بتلاقوا الـ Corona
+
+32
+00:02:55,010 --> 00:03:04,310
+إذا بناخدها الـ Corona عبارة عن ثلاث أنواع من
+
+33
+00:03:04,310 --> 00:03:10,450
+الفحوصات الـ «كورونا» والفيروس ما هو نوع المادة
+
+34
+00:03:10,450 --> 00:03:14,630
+الوراثية تبعته؟
+
+35
+00:03:14,630 --> 00:03:22,270
+الـ RNA الـ RNA بدأ يعطي إيش؟ ما يحاولون استخدامه
+
+36
+00:03:22,270 --> 00:03:27,110
+أحيانًا كلقاح أو يستخدموه في الفحص  بتعطي
+
+37
+00:03:27,110 --> 00:03:32,640
+بروتين اللي هو أكثر شيء يعني بيسموه كورونا كورونا
+
+38
+00:03:32,640 --> 00:03:38,560
+يعني التاجي اللي زي التاج يعني عبارة عن التاج على
+
+39
+00:03:38,560 --> 00:03:44,060
+الرأس اللي هي spikes يعني زي الأشياء الحد البروزات
+
+40
+00:03:44,060 --> 00:03:49,440
+الحد على السطح فهذه يعني أنت بتعطي protein ماشي
+
+41
+00:03:49,440 --> 00:03:56,900
+فأنت أمام ثلاث مستويات من الفحص أنا ممكن بالـ PCR
+
+42
+00:03:56,900 --> 00:04:06,440
+بفحص على إيش؟ على وجود إيش؟ على وجود الـ RNA في
+
+43
+00:04:06,440 --> 00:04:11,600
+العينة يعني بدخل القطنة في أنف المريض أو في بلغم
+
+44
+00:04:11,600 --> 00:04:16,100
+المريض أو على سطح المريض بعمله مسحة ولا كذا والـ
+
+45
+00:04:16,100 --> 00:04:23,420
+PCR أنا بدور على نفس الـ  ما اسمه؟ المادة الوراثية
+
+46
+00:04:23,420 --> 00:04:27,320
+تبعت الفيروس على تبع الـ RNA، واضح؟
+
+47
+00:04:29,880 --> 00:04:34,720
+- تمام. – هل هي ممتازة؟ آه، آه، معك دلوقتي طيب،
+
+48
+00:04:34,720 --> 00:04:42,200
+الخيار الثاني عندي إني باخد برضه مسحة وباخد عينة
+
+49
+00:04:42,200 --> 00:04:45,420
+من المادة
+
+50
+00:04:45,420 --> 00:04:50,540
+أو من البلغم أو من الشيء بدور على البروتين تبع الفيروس
+
+51
+00:04:50,540 --> 00:04:55,520
+ففي الحالتين هذول أنا بدور على وجود نفس الفيروس
+
+52
+00:04:55,520 --> 00:05:02,200
+المادة الوراثية تبعته بالـPCR أو الـ Protein تبعه
+
+53
+00:05:02,200 --> 00:05:10,800
+فأنا بدور عليه شو النوع الثالث من الفحوصات؟ أنا
+
+54
+00:05:10,800 --> 00:05:14,700
+بدور على رد فعل المناعة اللي هم الـ
+
+55
+00:05:14,700 --> 00:05:19,420
+Immunoglobulins فالـ Immunoglobulins فيه الـ IgG
+
+56
+00:05:19,420 --> 00:05:24,420
+والـ IgM الـ IgM بيطلع في الـ acute infection  ممكن
+
+57
+00:05:24,420 --> 00:05:29,390
+أن تكون الالتهاب أوله، والـ IgG بيطلع بعدين بيصير
+
+58
+00:05:29,390 --> 00:05:34,810
+اللي هو الذاكرة تبع المناعة، وبيكون متأخر وبيظلوا
+
+59
+00:05:34,810 --> 00:05:40,290
+مدة طويلة فلما أنت تقرأ دراسة، وحابب أقول لك أنا فحصت
+
+60
+00:05:40,290 --> 00:05:45,980
+على الكورونا بدك تفهم منه ك... يعني عشان نفهم شو
+
+61
+00:05:45,980 --> 00:05:51,720
+اللي بحكيه، شو اللي بتكلم عنه، شو النقاط الإيجابية
+
+62
+00:05:51,720 --> 00:05:56,360
+والنقاط السلبية، بدك تشوف الثلاث أشياء هذه، اللي
+
+63
+00:05:56,360 --> 00:06:01,360
+هي أي نوع من الدراسة عملت، هل هي الـPCR؟ الـPCR
+
+64
+00:06:01,360 --> 00:06:07,060
+بدها  كتير أشياء وبدك تكون ما فيش إشي
+
+65
+00:06:07,060 --> 00:06:11,640
+من النوع من الـContamination، يعني التلوث يعني لو
+
+66
+00:06:11,640 --> 00:06:17,680
+العينة بطريقة ما اتلوثت بأي احتمال لشيء قريب أو
+
+67
+00:06:17,680 --> 00:06:22,780
+جزء من شخص آخر الـ PCR تبعه positive بتلاقيه
+
+68
+00:06:22,780 --> 00:06:26,900
+بتطلع لك positive يعني ممكن مثلاً جهاز الـ PCR
+
+69
+00:06:26,900 --> 00:06:31,340
+اشتغلوا عليه على مريض طلع إيجابي وظلت نتفات فيروس
+
+70
+00:06:31,340 --> 00:06:36,600
+في الجهاز لما انعقموه ما انعقم تماماً فلما أجوا
+
+71
+00:06:36,600 --> 00:06:39,740
+درسوا عينة ثانية من نفس الشخص العين السابقة صارت
+
+72
+00:06:39,740 --> 00:06:46,130
+positive فيه ممكن تفحص عن المادة الوراثية الـ RNA
+
+73
+00:06:46,130 --> 00:06:50,470
+تبعته بدا تسويلك PCR ممكن تدور على الـ Protein
+
+74
+00:06:50,470 --> 00:06:54,850
+تبعه تستخدموا الـ ELISA مثلاً الـ enzyme linked
+
+75
+00:06:54,850 --> 00:06:59,570
+immunosorbent assay فبتدور على الـ Protein وممكن
+
+76
+00:06:59,570 --> 00:07:04,810
+أنت تدور على الـ Antibody ضد الـ Antigen تبع الـ
+
+77
+00:07:04,810 --> 00:07:12,550
+Coronavirus فاهم عليّ؟ الفكرة إيش هي؟ الفكرة أنه بدك
+
+78
+00:07:12,550 --> 00:07:18,990
+تفهم شو القالة اللي معك تفحص على إيش بالضبط هل
+
+79
+00:07:18,990 --> 00:07:23,130
+أنت بتفحص على المادة
+
+80
+00:07:23,130 --> 00:07:27,510
+الوراثية الـ DNA أو الـ RNA؟ هل بتفحص على مستوى
+
+81
+00:07:27,510 --> 00:07:32,430
+البروتين؟ هل بتفحص إذا كانت DNA؟ ممكن أنا أشوف الـ
+
+82
+00:07:32,430 --> 00:07:38,790
+RNA؟ ماشي الحال، واضحة الفكرة؟ تمام يا دكتور، طب
+
+83
+00:07:38,790 --> 00:07:43,710
+وجدت فيها مثلاً أسماء واحد مثلاً جال إنه طلع في
+
+84
+00:07:43,710 --> 00:07:48,970
+الهدى سلبي في الـPCR وفي الـAntibody طلع إيجابي
+
+85
+00:07:48,970 --> 00:07:53,150
+يعني، يكون هذا جيد يعني طبعاً ممكن، يعني أنت
+
+86
+00:07:53,150 --> 00:07:58,010
+الـVirus بيظل عادة إذا منعت الإنسان طبيعي وكذا
+
+87
+00:07:58,010 --> 00:08:04,830
+بيظل مثلاً إيجابي أسبوعين، شهر، شهرين كثير، بعدين
+
+88
+00:08:04,830 --> 00:08:10,780
+الـVirus تقضي عليه المناعة فإذا
+
+89
+00:08:10,780 --> 00:08:16,840
+أنت جيت له، يعني لما نتكلم على دراسة هل مثلاً أنت
+
+90
+00:08:16,840 --> 00:08:21,560
+لقيت الإنسان هذا المصاب بالكورونا في أول يوم في
+
+91
+00:08:21,560 --> 00:08:27,120
+الإصابة، في فترة الحضانة، مش أنت لما إحنا عادة أي
+
+92
+00:08:27,120 --> 00:08:33,580
+جرثومة، بالأول نتعرض للجرثومة بتدخل في فترة حضانة
+
+93
+00:08:33,580 --> 00:08:37,680
+Incubation period المريض والإنسان بيكون طبيعي ولا
+
+94
+00:08:37,680 --> 00:08:42,460
+بيشكي من شيء طبيعي مئة بالمئة بعد أربع، خمس، عشر،
+
+95
+00:08:42,460 --> 00:08:47,920
+عشرين يوماً، أشهر حسب الفيروس أو البكتيريا أو كذا
+
+96
+00:08:47,920 --> 00:08:53,500
+بيبدأ الأعراض تظهر عنده فأنت خدته أول الالتهاب، آخر
+
+97
+00:08:53,500 --> 00:08:59,300
+الالتهاب، أنه مرحلة تكلمنا عن الـ IgG والـ IgM
+
+98
+00:08:59,300 --> 00:09:04,080
+هذول antibodies بتقول لك التهاب حديث within يعني
+
+99
+00:09:04,080 --> 00:09:10,280
+شهر ولا قديم أكثر من شهر صار له مثلاً فاهم عليك؟
+
+100
+00:09:10,280 --> 00:09:15,460
+يعني الـ IgG على الأقل بده أسبوع حتى يبدأ يظهر أول
+
+101
+00:09:15,460 --> 00:09:21,320
+مرة بيبين الـ IgM، ما بيبينش الـ IgG، واضح؟ طيب يا
+
+102
+00:09:21,320 --> 00:09:24,800
+دكتور، ممكن يصير تداخل مثلاً واحد الـfall with شيء
+
+103
+00:09:24,800 --> 00:09:31,650
+ممكن يصير تداخل ويظهر العينة إيجابية؟ شو رأيك؟ مش
+
+104
+00:09:31,650 --> 00:09:34,550
+عارف، ممكن فيروسات و… الـCorona Virus مختلف عن
+
+105
+00:09:34,550 --> 00:09:39,170
+الـInfluenza Virus تركيبته وشكله وشكل البروتين
+
+106
+00:09:39,170 --> 00:09:44,030
+تبعه والـRNA Sequence تبعه مختلف لكن نفس الأعراض
+
+107
+00:09:44,030 --> 00:09:52,760
+صحيح، ولما واحد يفلوز ممكن تكون بكتيريا ممكن تكون
+
+108
+00:09:52,760 --> 00:09:56,100
+أنواع كثيرة من الـ Viruses الـ Rotavirus الـ
+
+109
+00:09:56,100 --> 00:09:59,820
+Echovirus في أنواع كثيرة، مجموعة كبيرة من
+
+110
+00:09:59,820 --> 00:10:04,000
+الفيروسات الـ Epstein-Barr Virus، الـ CMV Virus في
+
+111
+00:10:04,000 --> 00:10:08,220
+مجموعة كبيرة من الفيروسات بتعمل لك رشح، الرشح يعني
+
+112
+00:10:08,220 --> 00:10:14,240
+من كلها التهاب لمجاري التنفسية العليا واضح؟ فأنت
+
+113
+00:10:14,240 --> 00:10:19,880
+يعني الـ Influenza كأعراض مش خاصة فقط بالـ Virus
+
+114
+00:10:19,880 --> 00:10:24,480
+الـ Influenza، لأ بس هو أكبر مجموعة بتعمل الـ
+
+115
+00:10:24,480 --> 00:10:31,460
+Influenza Virus في الـ Influenza أظن A و B وأشياء
+
+116
+00:10:31,460 --> 00:10:35,280
+زي ذلك كـ Influenza Virus وفي غير Influenza Virus
+
+117
+00:10:35,280 --> 00:10:40,380
+وفي الـ «Rota» والـ «Echo» يعني عدد كبير من
+
+118
+00:10:40,380 --> 00:10:45,500
+الفيروسات أنت مش شغل واحد يعني فكلمة «كورونا» هي
+
+119
+00:10:45,500 --> 00:10:51,530
+مجموعة مختلفة من الفيروسات وجديدة صارت يعني في كان
+
+120
+00:10:51,530 --> 00:10:56,930
+قبل عشر سنين جائحة قريبة Corona One اللي هو سموها
+
+121
+00:10:56,930 --> 00:11:04,370
+متلازمة الشرق الأوسط التنفسية الـMersa مش
+
+122
+00:11:04,370 --> 00:11:10,030
+الـ Mersa الـMesa اللي هي Middle Eastern  ليه
+
+123
+00:11:10,030 --> 00:11:13,870
+برضه من مجموعة الـCorona؟ ماشي، فشو النقطة اللي
+
+124
+00:11:13,870 --> 00:11:18,920
+بدي إياها؟ النقطة اللي بدي إياها أنه أنا لما بدي
+
+125
+00:11:18,920 --> 00:11:25,700
+أقرأ عن دراسة، بدي أقرأ واحد بيحكي كلام معين لازم
+
+126
+00:11:25,700 --> 00:11:32,180
+أنا أكون فاهماً شو قصده، كيف عملها، شو اللي عمله،
+
+127
+00:11:32,180 --> 00:11:37,420
+يمكن كل اللي عمله غلط، بغلط، يمكن، بيصير، فالآن
+
+128
+00:11:37,420 --> 00:11:41,240
+واضح، هي مدخل للّي بنناقشه هلأ
+
+129
+00:11:47,180 --> 00:11:54,280
+فإذاً يعني لما أخذنا مثال الكورونا أنا
+
+130
+00:11:54,280 --> 00:12:00,460
+قصدي فيه أنه على الأقل للآن أنا عندي ثلاث أنواع من
+
+131
+00:12:00,460 --> 00:12:05,340
+الفحوصات للكورونا ممكن أنا بفحص على الـ PCR أنا
+
+132
+00:12:05,340 --> 00:12:09,680
+بفحص على المادة الوراثية ممكن أنا أفحص على
+
+133
+00:12:09,680 --> 00:12:13,820
+البروتين تبعه لأن هذول الإثنتين إحنا بنحكي عن وجود
+
+134
+00:12:13,820 --> 00:12:19,430
+الفيروس ممكن أنا أجي أفحص على الرد فعل المناعة ضد
+
+135
+00:12:19,430 --> 00:12:24,810
+الفيروس مرات كثيرة في إصابات كثيرة ما بنقدر نلقط
+
+136
+00:12:24,810 --> 00:12:31,550
+الفيروس itself صعب لأنه ممكن يعني وأنت ماخذه من
+
+137
+00:12:31,550 --> 00:12:39,550
+الجسم الفيروس يموت ما يظلش ممكن يتحلل يعني ما يظلش
+
+138
+00:12:39,550 --> 00:12:43,590
+بس الـ Immunoglobulin بظل مدة أطول فممكن الـ
+
+139
+00:12:43,590 --> 00:12:49,710
+Immunoglobulin أستخدمه عشان ألاقي الإثبات أنه اللي
+
+140
+00:12:49,710 --> 00:12:55,410
+صار عند الإنسان هذا الإصابة والالتهاب بالفيروس معين
+
+141
+00:12:55,410 --> 00:13:05,190
+يعني هكذا، تمام؟ هسة الموضوع الـ «سلايد» هذول،
+
+142
+00:13:05,190 --> 00:13:13,550
+ماشي، خلينا نشوف شو اللي عملوه، يعني إذا أنتم
+
+143
+00:13:13,550 --> 00:13:20,140
+شايفين الـScreen اللي معكم، صح؟ صحيح طيب، شو اللي
+
+144
+00:13:20,140 --> 00:13:27,860
+عملوا هنا؟ منظر لما تتطلع عليه، ماشي، شو اسمه؟
+
+145
+00:13:27,860 --> 00:13:36,060
+هيك، بتتعقد، وبدك، يعني بتكون، شو اسمه؟ هيك،
+
+146
+00:13:36,060 --> 00:13:43,700
+بيصير الواحد كأنه يعني مش فاهم ومقصّر، هيك بتفكر
+
+147
+00:13:43,700 --> 00:13:49,740
+اللي حقها عبقري وما فيش بعده وما فيش قبله وكذا وكذا،
+
+148
+00:13:49,740 --> 00:13:52,760
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+149
+00:13:52,760 --> 00:13:54,780
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+150
+00:13:54,780 --> 00:13:54,920
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+151
+00:13:54,920 --> 00:13:57,680
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+152
+00:13:57,680 --> 00:13:58,140
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+153
+00:13:58,140 --> 00:14:01,780
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+154
+00:14:01,780 --> 00:14:12,840
+وكذا
+
+155
+00:14:13,450 --> 00:14:18,270
+حكينا أنا ممكن أدور على المادة الوراثية تبعته الـ
+
+156
+00:14:18,270 --> 00:14:23,210
+DNA الـ RNA للـ Corona ممكن على الـ Protein ممكن
+
+157
+00:14:23,210 --> 00:14:27,190
+على المناعة
+
+158
+00:14:27,190 --> 00:14:37,030
+تمام؟ واضحة النقطة؟ تمام، تمام النقطة طيب، الآن أنا
+
+159
+00:14:37,030 --> 00:14:46,520
+بإمكاني أفحص على كمية شغل الـ Gene فاهم عليّ؟ الآن
+
+160
+00:14:46,520 --> 00:14:56,000
+يعني الأصل في الـ أنه أنا في الإنسان، الإنسان DNA
+
+161
+00:14:56,000 --> 00:15:02,900
+مش RNA مش زي الكورونا، بس نفس المبدأ الـ RNA، الـ
+
+162
+00:15:02,900 --> 00:15:08,960
+DNA تبع الإنسان هو الأساس هو اللي فيه الشفرة
+
+163
+00:15:08,960 --> 00:15:17,570
+الوراثية هو اللي بيحدد، تمام؟ حكينا أنه في كل خلية
+
+164
+00:15:17,570 --> 00:15:23,530
+الجينات اللي من الـ 25 ألف جين اللي في كل الـ
+
+165
+00:15:23,530 --> 00:15:28,830
+Genome الجينات اللازمة لهاي الخلية حتى تعيش حتى
+
+166
+00:15:28,830 --> 00:15:35,210
+تشتغل حتى تسدي وظيفتها هي اللي بتتم تنشيطها، تمام؟
+
+167
+00:15:35,210 --> 00:15:42,860
+فبالمقابل أنه فيه جينات ثانية يتم تثبيتها يعني لازم
+
+168
+00:15:42,860 --> 00:15:47,960
+شيء معين من الجينات هذه تشتغل أكثر في هذه
+
+169
+00:15:47,960 --> 00:15:55,400
+الخلية خصيصاً وبالمقابل الجينات
+
+170
+00:15:55,400 --> 00:16:03,440
+الثانية، مجموعة ثانية من الجينات بتتم تثبيت شغلها
+
+171
+00:16:03,440 --> 00:16:10,060
+من ناحية إنها مش لازمة، النتيجة تبعها، يعني في
+
+172
+00:16:10,060 --> 00:16:14,280
+هذه الخلية هذا الجين ما له داعي فبالتالي خلاص
+
+173
+00:16:14,280 --> 00:16:20,440
+مسكر وكذا يعني مثلاً الـ Hemoglobin جين اللي حكينا
+
+174
+00:16:20,440 --> 00:16:24,900
+عنه هو أنت محتاجه في الـ Red Blood
+
+223
+00:21:17,840 --> 00:21:23,540
+هذا الجين وطلّق الـ RNA اللي راح يعطيني البروتين؟
+
+224
+00:21:25,550 --> 00:21:31,130
+بالنسبة للـHemoglobin gene في خلية عضلات أو خلية
+
+225
+00:21:31,130 --> 00:21:36,050
+جلد أو خلية White Blood Cells كم بدي يكون منه
+
+226
+00:21:36,050 --> 00:21:41,710
+شغال؟ ما لهوش لازمة، مش هيكون صفر، ما لهوش لازمة
+
+227
+00:21:41,710 --> 00:21:44,730
+في الـRed Blood Cells اللي أنتَ حكيت فيه الأول في
+
+228
+00:21:44,730 --> 00:21:51,770
+الـRed Blood Cells هتلاقي عشرات، مئات، آلاف من
+
+229
+00:21:51,770 --> 00:21:56,830
+الـRNA وبعدين من البروتين، فاهم عليّ؟ فهيكون فيه
+
+230
+00:21:56,830 --> 00:22:00,410
+تفاوت، فما في باقي الخلايا ما لهوش لازمة، مش هيشتغل
+
+231
+00:22:00,410 --> 00:22:06,090
+مش هيشتغل، فهنا، شو اللي عملوه في الدراسة هذه؟ شو اللي
+
+232
+00:22:06,090 --> 00:22:14,470
+عملوا؟ أول شيء، عندهم ثمانية أشخاص مثلاً، عندهم أربعة
+
+233
+00:22:14,470 --> 00:22:22,800
+أشخاص مثلاً عندهم سرطان معين، وأخذوا الخلايا
+
+234
+00:22:22,800 --> 00:22:33,480
+السرطانية منهم، ماشي؟ وأخذوا
+
+235
+00:22:33,480 --> 00:22:42,020
+أربعة أشخاص أو ثمانية أشخاص، مش خلايا سرطانية، سواء من
+
+236
+00:22:42,020 --> 00:22:47,330
+نفس البني آدمين، يعني أنتَ بتاخد المرجع تبعك لنفس
+
+237
+00:22:47,330 --> 00:22:52,730
+الأشخاص، بس خلايا مش سرطانية، أو بتاخد إنسان طبيعي،
+
+238
+00:22:52,730 --> 00:22:58,710
+يعني ممكن هاي، ممكن هاي، ماشي الحال؟ الـtest هنا
+
+239
+00:22:58,710 --> 00:23:08,860
+هو لموضوع قد إيش الجين اشتغل، فاهم عليّ كيف؟ قد إيش هذا
+
+240
+00:23:08,860 --> 00:23:13,260
+الجين شغال؟ أنا لسه هنا ما... مش أنا بفحص بشكل
+
+241
+00:23:13,260 --> 00:23:19,080
+متخصص زي مثلًا تقول لي والله أخدت أنا panel أو
+
+242
+00:23:19,080 --> 00:23:24,840
+مجموعة هنا، بيقولوا دارسين  meat genes ماشي؟
+
+243
+00:23:24,840 --> 00:23:29,020
+وبيحاولوا يشوفوا قد إيش الجين اشتغل، فأفرض الـmeat
+
+244
+00:23:29,020 --> 00:23:33,580
+genes في عندك immunoglobulin genes وهي واحد من
+
+245
+00:23:33,580 --> 00:23:38,060
+الـhemoglobin genes هي اثنين، الكيراتين في الجلد مثلًا
+
+246
+00:23:38,060 --> 00:23:42,300
+بروتين الكيراتين في الجلد برضه دخلته، الأكتين
+
+247
+00:23:42,300 --> 00:23:48,100
+و المايوسين تبعان العضلات برضه أخدتهم، فالآن لما أنا
+
+248
+00:23:48,100 --> 00:23:54,640
+آجي، أنا عندي أربعة أو خمس جينات، كل واحد في محل
+
+249
+00:23:54,640 --> 00:23:59,660
+بيشتغل وفي محل ما له داعي، فما عليك كده، فلما أنا
+
+250
+00:23:59,660 --> 00:24:06,190
+آجي أفحص قد إيش في اللي عنده سرطان في الخلايا
+
+251
+00:24:06,190 --> 00:24:12,690
+السرطانية، قد إيش كل جين يا إما بيشتغل أكثر من
+
+252
+00:24:12,690 --> 00:24:19,390
+الاعتيادي أو أقل من الاعتيادي، فأنت هنا يعني هدول
+
+253
+00:24:19,390 --> 00:24:23,050
+هنا اللي بيحكوا لك علي كل واحد من هالخطوط هدول
+
+254
+00:24:23,050 --> 00:24:27,410
+العينات، شايف وين individual sample profile شفتها؟
+
+255
+00:24:27,410 --> 00:24:35,210
+أول واحدة، هنا درسوا عشرة في عشرة meat genes، و بيدوروا
+
+256
+00:24:35,210 --> 00:24:39,490
+على الـmessenger RNA أو على البروتين الناتج عنه
+
+257
+00:24:39,490 --> 00:24:47,150
+و بيقدروا يشوفوا هل الجين هذا هو شغال أكثر من
+
+258
+00:24:47,150 --> 00:24:53,110
+الاعتيادي أو أقل من الاعتيادي، وهنا الـ...أنت شايف
+
+259
+00:24:53,110 --> 00:24:56,810
+هنا؟ أنا بأُشير لك هنا individual sample profile
+
+260
+00:24:56,810 --> 00:25:03,940
+عظيمة، هذه أول واحدة اللي
+
+261
+00:25:03,940 --> 00:25:07,840
+كانت بيلاك عليها expression level العالية اللي
+
+262
+00:25:07,840 --> 00:25:16,520
+تحت هذه، إذا أصفر معناته مقارنة بغيره، مقارنة بالـ
+
+263
+00:25:16,520 --> 00:25:21,140
+normal، سواء normal individual أو normal cell في
+
+264
+00:25:21,140 --> 00:25:28,700
+الإنسان نفسه، المعدل التنشيط هذا الـgene هنا زي وزي
+
+265
+00:25:28,700 --> 00:25:37,890
+غير الخلايا الثانية، هنا أربعة أضعاف الإنتاج، وهنا ربع
+
+266
+00:25:37,890 --> 00:25:42,270
+الإنتاج، يعني هنا لما نكون إشي أحمر معناته هذه
+
+267
+00:25:42,270 --> 00:25:47,270
+الخلية اللي أنا أخدتها ما صنعت هذا الـ الـ
+
+268
+00:25:47,270 --> 00:25:52,590
+البروتين، هذا الجين في هذه الخلية مش شغال، ما لهوش
+
+269
+00:25:52,590 --> 00:25:57,770
+قيمة، وهنا هذا الإشي اللي شغلته كثير اللي لونه
+
+270
+00:25:57,770 --> 00:26:04,610
+أخضر، تمام؟ معيّ للآن؟ ‏- تمام ‏- للآن شو
+
+271
+00:26:04,610 --> 00:26:15,420
+بيعملوا؟ هنا لكل إنسان من العشرة أو ثمانية حالات، لـmeat
+
+272
+00:26:15,420 --> 00:26:23,320
+genes، وعرفنا لكل واحد شو عنده، ماشي؟ وهي يعني القصد
+
+273
+00:26:23,320 --> 00:26:28,040
+في الموضوع أنه أنتَ عندك كمبيوتر وجهاز قوي كثير
+
+274
+00:26:28,040 --> 00:26:32,520
+بيقرأ الأشياء بسرعة و بيقارنها ببعض و بيطلع لك الصورة
+
+275
+00:26:32,520 --> 00:26:38,810
+هذه، الآن هذول meat genes بس لسه أنا ما عندي تصور في
+
+276
+00:26:38,810 --> 00:26:44,070
+المرض هذا، السرطان من هذا النوع، أنه الجينات اللي
+
+277
+00:26:44,070 --> 00:26:49,110
+مرتبطة بوجود هذا النوع من السرطان إنها أكثر، شو
+
+278
+00:26:49,110 --> 00:26:57,290
+بقوم بعمل؟ بعدين بجيب نفس المعلومات اللي هنا الـ
+
+279
+00:26:57,290 --> 00:27:02,270
+individual sample profile اللي طلعتها بالأول، بعملها
+
+280
+00:27:02,270 --> 00:27:11,370
+أنه بعيد ترتيبها بهذا الشكل، بقص يعني نفس المعلومة
+
+281
+00:27:11,370 --> 00:27:21,490
+يعني إذا تنتبه، sample رقم واحد، شفتها؟ آه، بدل
+
+282
+00:27:21,490 --> 00:27:27,730
+ما هي بالمربعات، أسكتها طولاً، خليك معاه قليل شوية
+
+283
+00:27:27,730 --> 00:27:34,240
+sample رقم واحد، فَ هذه الميّ اللي هنا اللي بشكل مربع
+
+284
+00:27:34,240 --> 00:27:40,360
+فردناهم بهذا الشكل، فأول نتيجة لأول زاوية شو كانت
+
+285
+00:27:40,360 --> 00:27:48,160
+أحمر ولا أخضر ولا أصفر؟ أحمر، فهنا أول واحدة حمرة
+
+286
+00:27:48,160 --> 00:27:55,220
+آخر واحدة من هذه الجهة حطينا هنا أصفر، وهنا حطينا
+
+287
+00:27:55,220 --> 00:28:00,950
+أخضر، غلط، يعني بعتبر أنه بضحكوا علينا، ماشي، بس الأصل
+
+288
+00:28:00,950 --> 00:28:05,070
+أنه يعني فرضوا النتيجة اللي من الـindividual
+
+289
+00:28:05,070 --> 00:28:12,010
+sample حطوه جنب بعض بهذا الشكل، تمام؟ والأصل ترتيب
+
+290
+00:28:12,010 --> 00:28:17,030
+الجينات، واحد، اثنين، ثلاثة، مئة جين، هيك رتبوه
+
+291
+00:28:17,030 --> 00:28:25,990
+بهذا الشكل، ماشي الحال؟ أما في عندك أنتَ العينات
+
+292
+00:28:25,990 --> 00:28:31,660
+من السرطان، وعينات من خلايا طبيعية أو عينات من مرضى
+
+293
+00:28:31,660 --> 00:28:38,280
+السرطان وعينات من بني آدم طبيعي، بالأخير، بالنسبة
+
+294
+00:28:38,280 --> 00:28:41,340
+لتقييم
+
+295
+00:28:41,340 --> 00:28:51,700
+الموضوع أنه أنا بقيم بالنسبة للسرطانات، بالنسبة
+
+296
+00:28:51,700 --> 00:29:00,590
+للجينات من واحد لمئة، ما هو الشيء الذي يشغّل هذا
+
+297
+00:29:00,590 --> 00:29:04,390
+الجين من السرطان،
+
+298
+00:29:04,390 --> 00:29:11,810
+وهو اللون الأخضر، اللي عنده سرطان معين، أنه الجين
+
+299
+00:29:11,810 --> 00:29:18,270
+اللون أحمر، يعني ما بيشتغلش، فوجود الاختلالات هذه
+
+300
+00:29:18,960 --> 00:29:26,000
+بتأشر لك وين المسبب لهذا السرطان، كيف بغير شغل
+
+301
+00:29:26,000 --> 00:29:31,240
+الجينات في هذه العينة، وفي هذه الدراسة، فاهم عليّ
+
+302
+00:29:31,240 --> 00:29:40,140
+كيف؟ فهذه دراسة افتراضية، إحنا
+
+303
+00:29:40,140 --> 00:29:45,920
+هنا بندرس الـGene Expression Profiling من ثمانية
+
+304
+00:29:45,920 --> 00:29:52,940
+عينات، و100 جين أنا بدور عليهم، فاهم عليّ كيف؟ ومع
+
+305
+00:29:52,940 --> 00:29:56,820
+ذلك، ما هي الـ100 جينات؟ و ليش بالضبط أنا سويتهم؟
+
+306
+00:29:56,820 --> 00:30:01,420
+و كذا، يعني يمكن صعب، وما بيكونوا لسه يعرفوا يعني
+
+307
+00:30:01,420 --> 00:30:08,460
+طريقة تصميم هذه الدراسة بتكون علشان يعني يعني
+
+308
+00:30:08,460 --> 00:30:16,140
+بتكون علشان باستخدام الـsequencer أو بيسموها الـ
+
+309
+00:30:16,140 --> 00:30:21,700
+second generation sequencer، عبارة عن أجهزة بتقيس
+
+310
+00:30:21,700 --> 00:30:26,860
+لها، بتقرأ لك الـDNA بشكل صاروخي، يعني سريع جداً،
+
+311
+00:30:26,860 --> 00:30:32,600
+وعندك معلومات كثيرة وبدك بعدين تحاول تفهمها،
+
+312
+00:30:32,600 --> 00:30:38,580
+فمعناك كيف؟ فلما تقول في السرطان اللي فلان من
+
+313
+00:30:38,580 --> 00:30:41,660
+النوعية اللي فلانة، الجين اللي فلان و الجين اللي
+
+314
+00:30:41,660 --> 00:30:48,400
+علان، يعني هنا ما نقدر نقوله، إذا بتلاحظ، سرطان من
+
+315
+00:30:48,400 --> 00:30:53,760
+النوع A ويمكن بدل tumor B ممكن تكون الإنسان طبيعي
+
+316
+00:30:53,760 --> 00:31:00,300
+فلما تقوم بتعمل المقارنة، واضح إن مثلاً الجين رقم
+
+317
+00:31:00,300 --> 00:31:07,230
+واحد اللي عندهم السرطان A، شوف العينات 2 و3 و6 و8،
+
+318
+00:31:07,230 --> 00:31:13,690
+الجين هذا شغال كثير، بينما اللي ما عنده مش سرطان أو
+
+319
+00:31:13,690 --> 00:31:21,910
+سرطان ثاني، هذا الجين كان مش شغال، و مثبت كثير، يعني
+
+320
+00:31:21,910 --> 00:31:27,990
+بنرتبهم بهذا الشكل، اللي هنا هو أنا شغال كثير ومش
+
+321
+00:31:27,990 --> 00:31:32,790
+شغال، وهنا بالعكس، هون هاي الجينات هون شغال كثير
+
+322
+00:31:32,790 --> 00:31:38,530
+وهون مش شغالة، يعني تقدر تستنتج من الدراسة هذه أنه
+
+323
+00:31:38,530 --> 00:31:43,770
+بتقول مثلاً اللي عنده tumor A الجين رقم واحد ورقم
+
+324
+00:31:43,770 --> 00:31:50,490
+خمسة وعشرين، ورقم مثلاً سبعة وعشرين، هدول بيكونوا أكثر
+
+325
+00:31:50,490 --> 00:31:55,840
+بكثير من الـcontrol، و الجينات الأخرى، رقم كذا ورقم
+
+326
+00:31:55,840 --> 00:32:02,960
+كذا ورقم كذا، مثبتة أكثر بكثير من الـcontrol، "هيك
+
+327
+00:32:02,960 --> 00:32:09,280
+بدك تعيد، بتعيد، بتعيد"، فهي يعني صورة بتعقد، وإذا
+
+328
+00:32:09,280 --> 00:32:15,200
+ما كان الشرح عليها واضح كثير، ما لها قيمة يعني
+
+329
+00:32:15,200 --> 00:32:22,100
+واحد عنده أرقام وبيعرضها، وما لهاش قيمة، أو إنه ممكن
+
+330
+00:32:22,100 --> 00:32:22,480
+إذا
+
+331
+00:32:25,760 --> 00:32:29,980
+الارتباط بين هذا النوع من السرطان مع شغل هذا الجين
+
+332
+00:32:29,980 --> 00:32:35,140
+إذا قوي كثير، المفروض يكون مؤشر إنك تروح تدرسه
+
+333
+00:32:35,140 --> 00:32:38,620
+أكثر، أروح أدور شو طبيعة البروتين اللي بتطلعه هذا
+
+334
+00:32:38,620 --> 00:32:44,720
+الجين؟ شو دوره؟ ليش بيخليه؟ شو وظيفته؟ هيك بنقدم
+
+335
+00:32:44,720 --> 00:32:48,780
+الطب و بندرس هذا الموضوع، أتمنى أني أكون شرحت
+
+336
+00:32:48,780 --> 00:32:56,130
+الصورة هذه، اللي هي أنه يعني بدك يكون أول شيء عندك
+
+337
+00:32:56,130 --> 00:33:00,450
+الآلة اللي بتعمل هذا الشيء، ويكون العينات أخدتها
+
+338
+00:33:00,450 --> 00:33:08,550
+بشكل سليم، وبعدين تحاول تدرس شو العلاقة بين النقاط
+
+339
+00:33:08,550 --> 00:33:13,870
+هذه، الطريق
+
+340
+00:33:13,870 --> 00:33:18,010
+اللي سلكناه
+
+341
+00:33:18,010 --> 00:33:20,450
+من قبل، هو
+
+342
+00:33:23,350 --> 00:33:32,090
+يعني الـGene Expression Profiling، يعني عن طريق
+
+343
+00:33:32,090 --> 00:33:36,530
+مثلًا الـmessenger RNA، عن طريق يمكن البروتين
+
+344
+00:33:36,530 --> 00:33:41,270
+الناتج، بس في الغالب عن طريق الـmessenger RNA أنا
+
+345
+00:33:41,270 --> 00:33:51,350
+بعمل، شو اسمه؟ بشوف كمية شغل هذا البروتين، هذا الـ
+
+346
+00:33:51,350 --> 00:33:57,310
+gene، هل هو فاعل و شغال أو خامل و لم يكن له قيمة؟ لم
+
+347
+00:33:57,310 --> 00:34:02,110
+يتم الاستفادة منه؟ لم يكن له دور في هذه الخلايا؟
+
+348
+00:34:05,770 --> 00:34:10,990
+فالطريقة الأولى، ما حددوش عندي بالضبط شو هو الـ
+
+349
+00:34:10,990 --> 00:34:15,230
+Gene Expression، شو اسمه الـGene Expression، الـGene
+
+350
+00:34:15,230 --> 00:34:15,570
+Expression، الـGene Expression، الـGene Expression،
+
+351
+00:34:15,570 --> 00:34:15,630
+الـGene Expression، الـGene Expression، الـGene
+
+352
+00:34:15,630 --> 00:34:15,930
+Expression، الـGene Expression، الـGene Expression،
+
+353
+00:34:15,930 --> 00:34:19,550
+الـGene Expression، الـGene Expression، الـGene
+
+354
+00:34:19,550 --> 00:34:26,850
+Expression، الـGene Expression، الـGene
+
+355
+00:34:26,850 --> 00:34:31,690
+Expression،
+
+356
+00:34:31,690 --> 00:34:38,970
+الورقة العلمية اللي هم كاتبينها، مفروض تعطيك مرجع
+
+357
+00:34:38,970 --> 00:34:46,870
+بيحدد بالضبط كيف عملوا الفحص هذا، "شو الجينات
+
+358
+00:34:46,870 --> 00:34:53,970
+بالتفصيل؟"، بحوّلُك لمرجع آخر بيشرحوا فيه "شو هذه
+
+359
+00:34:53,970 --> 00:35:02,570
+الألوان الأخضر والأصفر والأحمر اللي سوّوها"، بنفس المبدأ، بنفس
+
+360
+00:35:02,570 --> 00:35:11,110
+الطريقة، ممكن أنا أعمل يعني هنا باستخدام microarray
+
+361
+00:35:11,110 --> 00:35:19,090
+analysis، بجيب series of tumors، ماشي، مثلاً نفترض أنا
+
+362
+00:35:19,090 --> 00:35:25,400
+هنا ناس عندهم سرطان الرئة، سرطان الرئة، طبعاً ممكن
+
+363
+00:35:25,400 --> 00:35:29,980
+يكون مش من الرئة نفسها، ممكن من محل ثاني في الجسم،
+
+364
+00:35:29,980 --> 00:35:33,820
+من المعدة، من القولون، طار على الرئة، بيصير، بس
+
+365
+00:35:33,820 --> 00:35:38,240
+ممكن تكون سرطان رئة مثلاً، في small cell carcinoma،
+
+366
+00:35:38,240 --> 00:35:43,520
+في non-small cell carcinoma، في large cell، في
+
+367
+00:35:43,520 --> 00:35:48,120
+squamous cell، في adenocarcinoma، كل واحد من هدول
+
+368
+00:35:48,120 --> 00:35:55,920
+نوع من السرطانات، من سرطانات الرئتين، طيب، أنا مثلاً
+
+369
+00:35:55,920 --> 00:36:01,940
+أخذت ناس عندهم small cell carcinoma، مظهرياً
+
+370
+00:36:01,940 --> 00:36:10,440
+لما أنا آخذ العينة بتكون هاي small cell carcinoma،
+
+371
+00:36:10,440 --> 00:36:16,620
+ماشي؟ باللاّقي، لما نيجي إحنا نعالج المرضى هذول،
+
+372
+00:36:16,620 --> 00:36:23,000
+نتعامل معهم، بتلاقي والله في ناس يعني كأن السرطان
+
+373
+00:36:23,000 --> 00:36:29,840
+حميد أكثر، يعني بطيء، بتلاقي مثلًا والله طول، وفي
+
+374
+00:36:29,840 --> 00:36:36,540
+ناس بتلاقي شديد جداً، بتلاقي السرطان خلال أسابيع
+
+375
+00:36:36,540 --> 00:36:40,640
+أو أشهر قضى على الإنسان، قضى على المريض، ليش هيك
+
+376
+00:36:40,640 --> 00:36:49,000
+اختلفوا؟ فافترض إنه أنا مثلاً، عندي مجموعة مثلاً ناس
+
+377
+00:36:49,000 --> 00:36:54,460
+عندهم سرطان small cell carcinoma، وقدرت أنا أميز
+
+378
+00:36:54,460 --> 00:37:01,540
+مجموعتين، ناس السرطان سريع كثير كثير كثير، وناس
+
+379
+00:37:01,540 --> 00:37:08,280
+السرطان بطيء، فبحاول أفهم ليش الاختلاف في السلوك
+
+380
+00:37:08,280 --> 00:37:16,090
+فهنا أنا أخدت مجموعة سرطانات، وعندي شيء ثاني استطعت
+
+381
+00:37:16,090 --> 00:37:20,830
+من خلاله أقسمهم لمجموعة cluster A و cluster B، يعني
+
+382
+00:37:20,830 --> 00:37:26,190
+هدول والله B اللي هم بطيئين، و cluster A سريعين
+
+383
+00:37:26,190 --> 00:37:33,950
+جداً وخبثين مثلاً، السرطان تبعهم، ماشي؟ هنا الأحمر هو
+
+384
+00:37:33,950 --> 00:37:40,010
+اللي يعني هاي بيتكلموا على أنه المرضى هدول الـ
+
+385
+00:37:40,010 --> 00:37:48,550
+survival، يعني عيشتهم، ويعني قد إيش سرعة السرطان بتأخذ
+
+386
+00:37:48,550 --> 00:37:53,320
+المريض، اللي عنده من النوع الأحمر، بتلاقي الناس
+
+387
+00:37:53,320 --> 00:37:59,300
+بتوفوا بحيث إنه أنا بالأشهر، خلال عشر سنين، هو أنا
+
+388
+00:37:59,300 --> 00:38:03,760
+ما ضلّ أربعين بالمية من الناس، بينما اللي عنده من
+
+389
+00:38:03,760 --> 00:38:10,540
+الـcluster B بعد عشر سنين مثلاً، تسعين بالمية من
+
+390
+00:38:10,540 --> 00:38:17,300
+الناس لسه أحياء، ما ماتوا، فإذا عندي أنا يعني
+
+391
+00:38:17,300 --> 00:38:22,850
+مؤشرات بهذه الطريقة، وبعدين بعمل microarray analysis،
+
+392
+00:38:22,850 --> 00:38:32,790
+هذه أسلوب الـmicroarray إنه أنتَ، شو اسمه؟ بتشوف
+
+393
+00:
+
+445
+00:43:48,890 --> 00:43:59,370
+28 اللي هو يُسمّى له «Kaplan» ولا «Genetics»؟ لأ
+
+446
+00:43:59,370 --> 00:44:08,930
+ليش «Kaplan»؟ طيب، الـ «Genetics» سؤال رقم 28 الأول
+
+447
+00:44:08,930 --> 00:44:16,270
+الأوائل ولا الفواني؟ الـ «Log» الأول 28، الـ «Log»
+
+448
+00:44:16,270 --> 00:44:19,070
+الأول طيب، هاي 26
+
+449
+00:44:24,760 --> 00:44:38,020
+27 هاي 28 طيب خليني أعمل share هاي
+
+450
+00:44:38,020 --> 00:44:45,620
+new share تقدر
+
+451
+00:44:45,620 --> 00:44:51,080
+تقرأ السؤال يا كريم؟ أه
+
+452
+00:44:51,080 --> 00:44:53,360
+بقرأ، بجد طيب يلّا
+
+453
+00:44:59,290 --> 00:45:03,330
+امرأة عمرها 19 عامًا كانت تتعامل مع مخاطرات
+
+454
+00:45:03,330 --> 00:45:09,990
+تونسية. في السنوات السابقة، كانت أيضًا تتعامل مع
+
+455
+00:45:09,990 --> 00:45:14,410
+مخاطرات إيراكية في أسطولها وعينها، وكذلك بخاطرات
+
+456
+00:45:14,410 --> 00:45:19,750
+عضوية. الفتاة كانت لديها عائلات مختلفة من الخارج،
+
+457
+00:45:19,750 --> 00:45:24,830
+مع إشعارات مشابهة، ومحاولة التجارب تتعامل معها،
+
+458
+00:45:24,830 --> 00:45:28,210
+وكانت تتعامل معها في الجزء الأسفل وفي البوابة
+
+459
+00:45:28,210 --> 00:45:34,280
+المساعدة. Skeletal muscle biopsy shows red
+
+460
+00:45:34,280 --> 00:45:37,380
+appearing muscle fibers. Further analysis reveals
+
+461
+00:45:37,380 --> 00:45:39,660
+that the patient's symptoms are due to mainly
+
+462
+00:45:39,660 --> 00:45:44,220
+extra nuclear DNA. Which of the following degree is
+
+463
+00:45:44,220 --> 00:45:47,980
+most likely to represent this patient's family
+
+464
+00:45:47,980 --> 00:45:51,380
+history؟ طيب،
+
+465
+00:45:51,380 --> 00:45:58,420
+أستاذ، شوف، خلينا نحاول يعني مرات كتير لأشياء زي
+
+466
+00:45:58,420 --> 00:46:05,700
+هيك أنا يمكن من حالي مش شايف الـ D بشكل واضح، ماشي
+
+467
+00:46:05,700 --> 00:46:09,540
+في
+
+468
+00:46:09,540 --> 00:46:14,340
+الصورة الثانية موجود الـ D؟ آه، بنزل عليها بعد
+
+469
+00:46:14,340 --> 00:46:18,460
+شوية، بس خلينا نشوف، بس شو اللي عرفناه من هذه
+
+470
+00:46:18,460 --> 00:46:25,620
+القصة؟ أول شيء، يعني أنا حكيت من قبل إنه تفاصيل
+
+471
+00:46:25,620 --> 00:46:32,740
+المادة العلمية يعني كمرض وشو اسم المرض هذا، يعني هي
+
+472
+00:46:32,740 --> 00:46:40,640
+عندها خلل في الأعصاب، ماشي، عندها نوبات صرع، يعني
+
+473
+00:46:40,640 --> 00:46:43,430
+tonic-clonic seizure اللي هم يعني
+
+474
+00:46:43,430 --> 00:47:05,110
+الـ………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………
+
+475
+00:47:12,010 --> 00:47:19,230
+وعندها بيصير الإصابة
+
+476
+00:47:19,230 --> 00:47:27,410
+تبعها مش بس عصبية حركية لأ عصبية حسية، فـ Decrease
+
+477
+00:47:27,410 --> 00:47:33,530
+sensation، ماشي، والمأثرة غير الـ Muscle weakness
+
+478
+00:47:33,530 --> 00:47:39,570
+أنه لما تمشي الإنسان زي لما يكون مثلًا إذا بتشوف
+
+479
+00:47:39,570 --> 00:47:43,890
+واحد سكران، واحد عنده بعث على العضلات، بيكون مفحج
+
+480
+00:47:43,890 --> 00:47:49,110
+رجليه كتير، بيحاول أنه عشان يحفظ توازنه، بيكون
+
+481
+00:47:49,110 --> 00:47:56,550
+إجراءه واسعات، فلقينا إنه في عندها Muscle weakness
+
+482
+00:47:56,550 --> 00:48:02,130
+وأخدوا من الـ Muscle Biopsy، لكوا في عندها مشكلة،
+
+483
+00:48:02,130 --> 00:48:10,950
+ماشي، ولما سوينا لها الـ… لما
+
+484
+00:48:10,950 --> 00:48:15,370
+سوينا لها الـ Muscle Biopsy، ماشي أو آسف، لما
+
+485
+00:48:15,370 --> 00:48:20,310
+سوينا لها الـ Genetic الدراسة، وين المشكلة كانت يا
+
+486
+00:48:20,310 --> 00:48:23,330
+كريم؟
+
+487
+00:48:23,330 --> 00:48:27,350
+عشان
+
+488
+00:48:27,350 --> 00:48:31,810
+سؤال بس، عشان جد لما كتبوا لك في السؤال في
+
+489
+00:48:31,810 --> 00:48:35,470
+الـ STEM «معلومات أخرى يظهر أن الشيء اللي يحدث في
+
+490
+00:48:35,470 --> 00:48:35,870
+الشيء اللي يحدث في الشيء اللي يحدث في الشيء اللي
+
+491
+00:48:35,870 --> 00:48:36,350
+يحدث في الشيء اللي يحدث في الشيء اللي يحدث في
+
+492
+00:48:36,350 --> 00:48:39,230
+الشيء اللي يحدث في الشيء اللي يحدث في الشيء اللي
+
+493
+00:48:39,230 --> 00:48:39,930
+يحدث في الشيء اللي يحدث في الشيء اللي يحدث في
+
+494
+00:48:39,930 --> 00:48:40,150
+الشيء اللي يحدث في الشيء اللي يحدث في الشيء اللي
+
+495
+00:48:40,150 --> 00:48:40,790
+يحدث في الشيء اللي يحدث في الشيء اللي يحدث في
+
+496
+00:48:40,790 --> 00:48:41,330
+الشيء اللي يحدث في الشيء اللي يحدث في الشيء اللي
+
+497
+00:48:56,860 --> 00:49:03,600
+فهي مثال على «Mitochondrial Disease»، ماشي، شو الـ
+
+498
+00:49:03,600 --> 00:49:07,160
+Characteristics بـ degree تبع الـ «Mitochondrial
+
+499
+00:49:07,160 --> 00:49:11,900
+Disease»؟ الـ «Mitochondrial» ينتقل إلى معلوم
+
+500
+00:49:11,900 --> 00:49:16,600
+لأبناء فقط، بس ورث الـ Female لـ الـ «G» اللي
+
+501
+00:49:16,600 --> 00:49:21,860
+وراها أكثر من هيك، بأثر على الـ «Males» ولا الـ
+
+502
+00:49:21,860 --> 00:49:26,210
+«Females»؟ بتصل على اثنين، ولكن ما بنتقل من جيل
+
+503
+00:49:26,210 --> 00:49:28,370
+لجيل إلا من الأم، بس الأم اللي بتولّي ثمانية
+
+504
+00:49:28,370 --> 00:49:34,950
+كروموسومات DNA، طيب، فإنت هسا الـ A، بنفع ولا ما بنفع؟
+
+505
+00:49:34,950 --> 00:49:39,710
+الـ A لأ أكيد، لإنه في على الشمال الأب موارثه لإبنه
+
+506
+00:49:39,710 --> 00:49:46,700
+آه، الأب ما بيصير يعني الإنسان أب يكون هو المصاب غلط
+
+507
+00:49:46,700 --> 00:49:50,220
+إنه يعطي .. بس على أقل إنه males و females
+
+508
+00:49:50,220 --> 00:49:54,380
+affected، okay، it goes with it يعني تمشي معاهم، بس
+
+509
+00:49:54,380 --> 00:50:00,860
+بما إنه الأب أعطى ولاده، هذا مش هو الـ issue الصحيح
+
+510
+00:50:00,860 --> 00:50:05,880
+الـ B صح ولا مش صح؟ الـ B is autosomal recessive،
+
+511
+00:50:05,880 --> 00:50:11,360
+فبرضه بره، نعم، الـ B is autosomal recessive، فبرضه
+
+512
+00:50:11,360 --> 00:50:13,660
+بره، أه، he skipped generation لإنه في skip
+
+513
+00:50:13,660 --> 00:50:19,500
+generation، ما بزبط، الـ C برضه فيه مشكلة، الأب أعطى
+
+514
+00:50:19,500 --> 00:50:26,200
+بناته، ما بيثبت، ماشي، أشوف الـ D وأنا ننزل تحت الـ
+
+515
+00:50:26,200 --> 00:50:34,500
+D، الأم أعطت أولادها وبناتها، ماعطتهمش، ما بيصير
+
+516
+00:50:34,500 --> 00:50:44,080
+يعني، والأم هي الـ affected، الـ E شو رأيك فيه؟ الجد
+
+517
+00:50:44,080 --> 00:50:52,500
+مفاعل أعطت ولدها وبناتها، كل ولدتك برضه وعطيتها؟
+
+518
+00:50:52,500 --> 00:50:57,680
+أنا ما عطاش إشي، بينما البنات هم اللي بعطيه وغانا
+
+519
+00:50:57,680 --> 00:51:05,320
+يعني أقرب إشي لهم شو إنه الحل E، فخليني نشوف كتبنا
+
+520
+00:51:05,320 --> 00:51:12,710
+الإجابة الـ E، بس أنت يعني الفكرة بدك تقرأ سم
+
+521
+00:51:12,710 --> 00:51:18,330
+السؤال شوية شوية براواقة وتحاول تفهم الأشياء اللي
+
+522
+00:51:18,330 --> 00:51:27,090
+معطينا فيها، لو تيجي تنتبه للسؤال مرة ثانية، الوصف
+
+523
+00:51:27,090 --> 00:51:33,060
+الأول كله ما له قيمة يعني بيخربطوا الواحد إنه
+
+524
+00:51:33,060 --> 00:51:36,000
+«Tonic» «Clonic» وكان عنده كده وكان عنده كده
+
+525
+00:51:36,000 --> 00:51:40,120
+وما عندهاش كده، يعني ما كانتش هي الإشي المهم، هذا الـ
+
+526
+00:51:40,120 --> 00:51:45,820
+«Distractor»، يعني هذا إشي بيضيع، أما لما تقرأ تشوف
+
+527
+00:51:45,820 --> 00:51:50,420
+إنه مثلًا أنا المطلوب مني أشوف شو الـ «Type of
+
+528
+00:51:50,420 --> 00:51:56,080
+Inheritance»، طيب الـ «Males» ولا «Females»
+
+529
+00:51:56,080 --> 00:52:00,790
+affected، هاي مهم كتير، هاي واحدة، إذا فيه هو أنا
+
+530
+00:52:00,790 --> 00:52:05,910
+حاطط لإيش ثاني؟ هو معطيك إنه extra nuclear DNA، يعني
+
+531
+00:52:05,910 --> 00:52:09,150
+بدي يكون Mitochondrial inheritance، هيك بده تكون
+
+532
+00:52:09,150 --> 00:52:12,450
+النتيجة، فبروح بدور، أيش الـ Mitochondrial؟ وهذا
+
+533
+00:52:12,450 --> 00:52:18,870
+سؤال بعتبره سهل، أنه هاي 84% يعني من كل ثمانية
+
+534
+00:52:18,870 --> 00:52:26,330
+سبعة جاوبوا صح، ماشي؟ هيك بدك تمشي بالـ «هيو دكتور»؟
+
+535
+00:52:26,330 --> 00:52:26,690
+آه
+
+536
+00:52:29,890 --> 00:52:36,610
+دكتور أحمد، أنا مضطر الآن، في عندي كمان شغل بعد شوية
+
+537
+00:52:36,610 --> 00:52:42,170
+يوم الأربعاء، الأربعاء بيكون امتحان الـ Quiz الأخير
+
+538
+00:52:42,170 --> 00:52:47,050
+شايف عليه؟ ما عليهوش علامة، بس يعني عشان تدريب أو
+
+539
+00:52:47,050 --> 00:52:52,590
+بنشوف كيف بنتعامل معه، وبعد الـ… يعني مثلًا نقول
+
+540
+00:52:52,590 --> 00:52:56,590
+يوم الاثنين القادم، بتحبوا نقعد مرة ثانية؟ إذا حد
+
+541
+00:52:56,590 --> 00:53:01,540
+عنده أسئلة زي هذا؟ إذا ما بدناش نقعد على الـ Zoom
+
+542
+00:53:01,540 --> 00:53:06,220
+فيه، الـ «جروب» تبع الـ Medical Genetics، أتأمّل أنه
+
+543
+00:53:06,220 --> 00:53:10,400
+على الـ WhatsApp، بنقدر نستفيد منها، يعني اللي بيحط،
+
+544
+00:53:10,400 --> 00:53:17,420
+ما حد يتواصل معايا، درجاءً من طالب شخصي، يعني واحد
+
+545
+00:53:17,420 --> 00:53:21,280
+دواحد، اللي بيده أي سؤال من خلال الـ «جروب» الـ
+
+546
+00:53:21,280 --> 00:53:25,720
+Medical Genetics، بيحط السؤال للجميع وأنا بجاوب
+
+547
+00:53:25,720 --> 00:53:27,580
+للجميع، ماشي الحال؟
+
+548
+00:53:33,180 --> 00:53:41,520
+الله يوفقكم، والله يحفظكم، وإن شاء الله أكون قدرت
+
+549
+00:53:41,520 --> 00:53:47,960
+أني يعني أوصل أفكاري، ماشي يا كريم ويا معتز والشباب
+
+550
+00:53:47,960 --> 00:53:52,980
+والدكتورات، الكل يعني، يا عزيزي، عفوًا يا دكتور، الله
+
+551
+00:53:52,980 --> 00:53:58,600
+يبارك فيك، الله يحييكم، أي واحد عنده أي سؤال يفضله
+
+552
+00:53:58,600 --> 00:54:08,200
+على group المساق للكل، ويحاول يعني يكون عنده يعني
+
+553
+00:54:08,200 --> 00:54:13,160
+يودّينا شو هو السؤال بشكل واضح، ممكن واحد يتكلم
+
+554
+00:54:13,160 --> 00:54:20,160
+يعني دكتور، بس أكّد أكّد لكريم على علامة، حكيت للدكتور
+
+555
+00:54:20,160 --> 00:54:25,080
+احفظها خلاص، اللي موجودين كلهم كانوا يحضروا كتير
+
+556
+00:54:25,080 --> 00:54:30,520
+يعني، غير علامة كريم، الموجودين كلهم إنهم علامة
+
+557
+00:54:30,520 --> 00:54:34,220
+لأنهم كانوا من ضمن يعني الناس الملتزمين دائمًا، ما في
+
+558
+00:54:34,220 --> 00:54:41,060
+مشكلة، ما في مشكلة، الدكتور أحمد، يعني أنا المشاركة
+
+559
+00:54:41,060 --> 00:54:45,060
+يعني صراحة هو صحيح، إلها دور وإلها نشاط، أه، أنا
+
+560
+00:54:45,060 --> 00:54:51,400
+يعني مع أنه يعني نحط لهم bonus للي حضروا، وللي حضروا
+
+561
+00:54:51,400 --> 00:54:56,260
+المرة هذه بالتالي، الله يوفقهم وإن شاء الله بيبقوا
+
+562
+00:54:56,260 --> 00:55:01,380
+على تواصل، إن شاء الله يوم الأربعاء، يعني يوم
+
+563
+00:55:01,380 --> 00:55:08,160
+الثلاثاء بدّك الأسئلة يا دكتور أحمد، وهذه الأمر أنا
+
+564
+00:55:08,160 --> 00:55:15,420
+موافق عليه، ومش… إن شاء الله شو اسمه؟ هتكون الأسئلة
+
+565
+00:55:15,420 --> 00:55:19,720
+عادية ولا فيها U word يا دكتور؟ نعم، هتكون الأسئلة
+
+566
+00:55:19,720 --> 00:55:24,340
+عادية ولا فيها U word؟ وإيش يعني؟ شو فيها؟ أسامة
+
+567
+00:55:24,340 --> 00:55:31,380
+بلكم مش تسأله هيك، ماشي، شو ما يجيلك حل، ماشي، الله
+
+568
+00:55:31,380 --> 00:55:38,860
+يُسهّل، الله يحييكم، يلا السلام عليكم، علينا، علينا، يلا
+
+569
+00:55:38,860 --> 00:55:39,700
+السلام عليكم
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/wEkbdETtaiE_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/wEkbdETtaiE_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..7f24fa0cad3011129c9dfe2dd731c874e4b9c6e3
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/wEkbdETtaiE_postprocess.srt
@@ -0,0 +1,2276 @@
+1
+00:00:00,000 --> 00:00:07,040
+نقطة معينة الآن الصورة
+
+2
+00:00:07,040 --> 00:00:18,180
+هذه صراحة بتعقد يعني بتخربط الواحد وبتلاقي
+
+3
+00:00:18,180 --> 00:00:21,600
+لما
+
+4
+00:00:21,600 --> 00:00:27,640
+تتذكر أي فصل هي موجودةبالنسبة لـ Identify Genetic
+
+5
+00:00:27,640 --> 00:00:34,380
+Basis قدرني الرقم فاصل عشرة أتوقع هيك خلّينا نشوف
+
+6
+00:00:34,380 --> 00:00:40,660
+هنا الآن
+
+7
+00:00:40,660 --> 00:00:44,880
+اللي
+
+8
+00:00:44,880 --> 00:00:49,160
+بنحكي عنه بالنسبة لل .. لأ مش فاصل عشرة
+
+9
+00:00:55,110 --> 00:00:57,930
+على مستوى الوزيارة الوزيارة الوزيارة الوزيارة
+
+10
+00:00:57,930 --> 00:01:00,230
+الوزيارة الوزيارة الوزيارة الوزيارة الوزيارة
+
+11
+00:01:00,230 --> 00:01:02,750
+الوزيارة الوزيارة الوزيارة الوزيارة الوزيارة
+
+12
+00:01:02,750 --> 00:01:04,490
+الوزيارة الوزيارة الوزيارة الوزيارة الوزيارة
+
+13
+00:01:04,490 --> 00:01:10,910
+الوزيارة الوزيارة الوزيارة الوزيارة
+
+14
+00:01:10,910 --> 00:01:14,550
+الوزيارة الوزيارة الوزيارة الوزيارة الوزيارة
+
+15
+00:01:14,550 --> 00:01:16,310
+الوزيارة الوزيارة الوزيارة الوزيارة الوزيارة
+
+16
+00:01:16,310 --> 00:01:20,470
+الوزيارة
+
+17
+00:01:20,960 --> 00:01:32,500
+إنه مطلوب من الواحد يقرأ أبحاث أو يعمل
+
+18
+00:01:32,500 --> 00:01:41,150
+دراسة معينة يفهم المبدأالـ Test اللي هو بيستخدموه
+
+19
+00:01:41,150 --> 00:01:47,910
+يعني هسة مثلا يعني أكبر مثال الآن لو سألت معتز انت
+
+20
+00:01:47,910 --> 00:01:52,630
+بتسمع عن الـ Corona ما Corona هذا و COVID-19 و
+
+21
+00:01:52,630 --> 00:01:59,110
+جائحة أو Pandemic يعني اشتاحت العالم كله، ماشي؟ شو
+
+22
+00:01:59,110 --> 00:02:05,030
+ال tests اللي عندنا؟ اللي هنا؟ مفروض، الآن مفروض
+
+23
+00:02:05,410 --> 00:02:10,430
+الواحد يكون على عبّينة وعلم شو الأشياء اللي تستخدم
+
+24
+00:02:10,430 --> 00:02:13,670
+لما يقولوا «هذا positive، هذا negative» «ليش هذا
+
+25
+00:02:13,670 --> 00:02:17,630
+positive؟ ليش هذا negative؟» بتشكل هذا فشو أنواع
+
+26
+00:02:17,630 --> 00:02:22,390
+الـ «Tests» اللي لنا أنت
+
+27
+00:02:22,390 --> 00:02:28,030
+حكيت كلمة اللي هي الـ «PCR» هم حقيقةً فيه ثلاث
+
+28
+00:02:28,030 --> 00:02:33,110
+أنواع من الفحوصات مش نوع واحدوبدّك تنتبه لما
+
+29
+00:02:33,110 --> 00:02:38,730
+يقولوا إنسان طلع إيجابي أو سلبي حسب شونه الـ Test
+
+30
+00:02:38,730 --> 00:02:44,950
+اللي استخدمه فالآن اللي لو أخدنا مثال الـ Corona
+
+31
+00:02:44,950 --> 00:02:55,010
+الـ Corona بتلاقوا ثواني، أه بتلاقوا الـ Corona
+
+32
+00:02:55,010 --> 00:03:04,310
+إذا بناخدها الـ Corona إبارة عنثلاث أنواع من
+
+33
+00:03:04,310 --> 00:03:10,450
+الفحوصات الـ «كورونا» والفيروس ما هو نوع المادة
+
+34
+00:03:10,450 --> 00:03:14,630
+الورافية تبعته؟
+
+35
+00:03:14,630 --> 00:03:22,270
+الـ RNA الـ RNA بدأ تعطي إيش؟ ما يحاولون استخدامه
+
+36
+00:03:22,270 --> 00:03:27,110
+أحيانًا كلقاح أو يستخدموه في الفحص و لا كده، بتعطي
+
+37
+00:03:27,110 --> 00:03:32,640
+بروتيناللي هو أكثر شيء يعني بيسموه كورونا كورونا
+
+38
+00:03:32,640 --> 00:03:38,560
+يعني التاجي اللي زي التاج يعني عبارة عن التاج على
+
+39
+00:03:38,560 --> 00:03:44,060
+الرأس اللي هي spikes يعني زي الأشياء الحد البروزات
+
+40
+00:03:44,060 --> 00:03:49,440
+الحد على السطح فهذه يعني أنت بتعطي protein ماشي
+
+41
+00:03:49,440 --> 00:03:56,900
+فانت أمام ثلاث مستويات من الفحص أنا ممكن بالـ PCR
+
+42
+00:03:56,900 --> 00:04:06,440
+بفحص على إيشعلى وجود إيش؟ على وجود الـ RNA في
+
+43
+00:04:06,440 --> 00:04:11,600
+العينة يعني بدخل القطنة في أنف المريض أو في بلغم
+
+44
+00:04:11,600 --> 00:04:16,100
+المريض أو على سطح المريض بعمله مسحة ولا كذا والـ
+
+45
+00:04:16,100 --> 00:04:23,420
+PCR أنا بدور على نفس الـ ما اسمه؟ المادة الوراثية
+
+46
+00:04:23,420 --> 00:04:27,320
+تبعت الفيروس على تبع الـ RNA، واضح؟
+
+47
+00:04:29,880 --> 00:04:34,720
+- تمام. – هل هي ممتاز؟ آه، آه، معاك دلوقتي طيب،
+
+48
+00:04:34,720 --> 00:04:42,200
+الخيار الثاني عندي إني باخد برضه مسحة و باخد عينة
+
+49
+00:04:42,200 --> 00:04:45,420
+من المادة
+
+50
+00:04:45,420 --> 00:04:50,540
+أو من البلغم أو من الإشي بدور البروتين تبع الفيروس
+
+51
+00:04:50,540 --> 00:04:55,520
+ففي الحالتين هذولة أنا بدور على وجود نفس الفيروس
+
+52
+00:04:55,520 --> 00:05:02,200
+المادة الوراثية تبعته بالـPCRأو الـ Protein تبعه
+
+53
+00:05:02,200 --> 00:05:10,800
+فأنا بدور عليه شو النوع الثالث من الفحوصات؟ أنا
+
+54
+00:05:10,800 --> 00:05:14,700
+بدور على رد فئل المناعة اللي هم الـ
+
+55
+00:05:14,700 --> 00:05:19,420
+Immunoglobulins فالـ Immunoglobulins فيه الـ IgG
+
+56
+00:05:19,420 --> 00:05:24,420
+والـ IgM الـ IgM بيطلع في الـ acute infection يمكن
+
+57
+00:05:24,420 --> 00:05:29,390
+أن تكون الالتهاب أولهوالـ IGG بيطلع بعدين بيصير
+
+58
+00:05:29,390 --> 00:05:34,810
+اللي هو الذاكرة تبع المناعة وبيكون متأخر وبيظلوا
+
+59
+00:05:34,810 --> 00:05:40,290
+مدة طويلة فلما أنت تقرأ دراسة وحابب أقولك أنا فحصت
+
+60
+00:05:40,290 --> 00:05:45,980
+على الكورونابدّك تفهم منه ك... يعني عشان نفهم شو
+
+61
+00:05:45,980 --> 00:05:51,720
+اللي بحكيه، شو اللي بتكلم عنه، شو النقاط الإيجابية
+
+62
+00:05:51,720 --> 00:05:56,360
+والنقاط السلبية، بدك تشوف الثلاث أشياء هذه، اللي
+
+63
+00:05:56,360 --> 00:06:01,360
+هي أي نوع من الدراسة عملت، هل هي الـPCR؟ الـPCR
+
+64
+00:06:01,360 --> 00:06:07,060
+بتول، الـPCR بده كت وبده أشياء وبدك تكون مافيش إشي
+
+65
+00:06:07,060 --> 00:06:11,640
+من النوع من الـContamination، يعني التلوثيعني لو
+
+66
+00:06:11,640 --> 00:06:17,680
+العينة بطريقة ما اتلوثت بأي احتمال لشيشي قريب أو
+
+67
+00:06:17,680 --> 00:06:22,780
+جزء من شخص آخر الـ PCR تبعه positive بتلاقيه
+
+68
+00:06:22,780 --> 00:06:26,900
+بتطلعلك positive يعني ممكن مثلا جهاز الـ PCR
+
+69
+00:06:26,900 --> 00:06:31,340
+اشتغلوا عليه على مريض طلع إيجابي وظلت نتفت فيروس
+
+70
+00:06:31,340 --> 00:06:36,600
+في الجهاز لما انعقموه ما اتعقمش تماما فلما أجوا
+
+71
+00:06:36,600 --> 00:06:39,740
+درسوا العين الثاني من سبب العين الأقدم صارت
+
+72
+00:06:39,740 --> 00:06:46,130
+positiveففيه ممكن تفحص عن المادة الورافية الـ RNA
+
+73
+00:06:46,130 --> 00:06:50,470
+تبعته بدا تسويلك PCR ممكن تدور على الـ Protein
+
+74
+00:06:50,470 --> 00:06:54,850
+تبعه تستخدموا الـ ELISA مثلا الـ enzyme linked
+
+75
+00:06:54,850 --> 00:06:59,570
+immunosorbent assay فبتدور على الـ Protein وممكن
+
+76
+00:06:59,570 --> 00:07:04,810
+أنت تدور على الـ Antibody ضد الـ Antigen تبع الـ
+
+77
+00:07:04,810 --> 00:07:12,550
+Coronavirus فهم علي؟ فالفكرة إيش هي؟الفكرة إنه بدك
+
+78
+00:07:12,550 --> 00:07:18,990
+تفهم شو القالة اللي معاك تفحص على إيش بالظبط هل
+
+79
+00:07:18,990 --> 00:07:23,130
+أنت بتفحص على المادة
+
+80
+00:07:23,130 --> 00:07:27,510
+الوراثية الـ DNA أو الـ RNA؟ هل بتفحص على مستوى
+
+81
+00:07:27,510 --> 00:07:32,430
+البروتين؟ هل بتفحص إذا كانت DNA؟ ممكن أنا أشوف الـ
+
+82
+00:07:32,430 --> 00:07:38,790
+RNA؟ ماشي الحال، واضحة الفكرة؟تمام يا دكتور، طب
+
+83
+00:07:38,790 --> 00:07:43,710
+وجدت فيها مثلًا أسماء واحد مثلًا جال إنه طلع في
+
+84
+00:07:43,710 --> 00:07:48,970
+الهدى سلبي في الـPCR وفي الـAntibody طلع إيجابي
+
+85
+00:07:48,970 --> 00:07:53,150
+يعني، يكون هدى جيد يعني طبعًا ممكن، يعني أنت
+
+86
+00:07:53,150 --> 00:07:58,010
+الـVirus بيظل عادة إذا منعت الإنسان طبيعي وكذا
+
+87
+00:07:58,010 --> 00:08:04,830
+بيظل مثلًا إيجابي أسبوعين، شهر، بني كثير، بعدين
+
+88
+00:08:04,830 --> 00:08:10,780
+الـVirus يقضي عليهابالمناعة فإذا
+
+89
+00:08:10,780 --> 00:08:16,840
+إنت جيتله، يعني لما نتكلم على دراسة هل مثلا إنت
+
+90
+00:08:16,840 --> 00:08:21,560
+لقيت الإنسان هذا المصاب بالكورونا في أول يوم في
+
+91
+00:08:21,560 --> 00:08:27,120
+الإصابة، في فترة الحضانة، مش إنت لما إحنا عادة أي
+
+92
+00:08:27,120 --> 00:08:33,580
+جرثومة، بالأول نتعرض للجرثومةبتدخل في فترة حضانة
+
+93
+00:08:33,580 --> 00:08:37,680
+Incubation period المريض والإنسان بيكون طبيعي ولا
+
+94
+00:08:37,680 --> 00:08:42,460
+بيشكي من إشي طبيعي مية بالمية بعد أربع، خمس، عشر،
+
+95
+00:08:42,460 --> 00:08:47,920
+عشرين مرات أشهر حسب الفيروس أو البكتيريا أو كذا
+
+96
+00:08:47,920 --> 00:08:53,500
+بيبدأ العراض تظهر عنده فأنت خدته أول الالتهاب، آخر
+
+97
+00:08:53,500 --> 00:08:59,300
+الالتهاب، أنه مرحلة متكلمنا عن الـ IgG والـ IgM
+
+98
+00:08:59,300 --> 00:09:04,080
+هذولة antibodiesبتقولّك التهاب حديث within يعني
+
+99
+00:09:04,080 --> 00:09:10,280
+شهر و لا قديم أكتر من شهر صار له مثلا فاهم عليك؟
+
+100
+00:09:10,280 --> 00:09:15,460
+يعني الـ IgG على الأقل بده أسبوع بما يبدأ يظهر أول
+
+101
+00:09:15,460 --> 00:09:21,320
+مرة بيبين الـ IgM، مابيبينش الـ IgG، واضح؟ طيب يا
+
+102
+00:09:21,320 --> 00:09:24,800
+دكتور، ممكن يصير تداخل مثلا واحد الـfall with إشي
+
+103
+00:09:24,800 --> 00:09:31,650
+ممكن يصير تداخل ويظهر العينة إيجابية؟ شو رأيك؟مش
+
+104
+00:09:31,650 --> 00:09:34,550
+عارف، ممكن فيروسات و… الـCorona Virus مختلف عن
+
+105
+00:09:34,550 --> 00:09:39,170
+الـInfluenza Virus تركيبته وشكله وشكل البروتين
+
+106
+00:09:39,170 --> 00:09:44,030
+تبعه والـRNA Sequence تبقى مختلف لكن نفس الأعراض
+
+107
+00:09:44,030 --> 00:09:52,760
+صحيح، ولمّا واحد يفلوزممكن تكون بكتيريا ممكن تكون
+
+108
+00:09:52,760 --> 00:09:56,100
+أنواع كثيرة من الـ Viruses الـ Rotavirus الـ
+
+109
+00:09:56,100 --> 00:09:59,820
+Echovirus في أنواع كثيرة، مجموعة كبيرة من
+
+110
+00:09:59,820 --> 00:10:04,000
+الفيروسات الـ Epstein-Barr Virus، الـ CMV Virus في
+
+111
+00:10:04,000 --> 00:10:08,220
+مجموعة كبيرة من الفيروسات بتعملك رشحة الرشحة يعني
+
+112
+00:10:08,220 --> 00:10:14,240
+من كلها التهاب لمجاري التنفسي العليا واضح؟فانت
+
+113
+00:10:14,240 --> 00:10:19,880
+يعني الـ Influenza كأعراض مش خاصة فقط بالـ Virus
+
+114
+00:10:19,880 --> 00:10:24,480
+الـ Influenza، لأ بس هو الأكبر مجموعة بتعمل الـ
+
+115
+00:10:24,480 --> 00:10:31,460
+Influenza Virus في الـ Influenza أظن A و B و أشياء
+
+116
+00:10:31,460 --> 00:10:35,280
+زي ذلك كـ Influenza Virus وفي برا Influenza Virus
+
+117
+00:10:35,280 --> 00:10:40,380
+وفيالـ «Rota» والـ «Echo» يعني عدد كبير من
+
+118
+00:10:40,380 --> 00:10:45,500
+الفيروسات أنت مش شغل واحد يعني فكلمة «كورونا» هي
+
+119
+00:10:45,500 --> 00:10:51,530
+مجموعة مختلفةمن الفيروسات وجديدة صارت يعني في كان
+
+120
+00:10:51,530 --> 00:10:56,930
+قبل عشر سنين جائحة قريبة Corona One اللي هو سموها
+
+121
+00:10:56,930 --> 00:11:04,370
+متلازمة المنطقة الشرق الأوسط التنفسية الـMersa مش
+
+122
+00:11:04,370 --> 00:11:10,030
+الـMersa الـMesa اللي هي Middle Eastern يعني ليه
+
+123
+00:11:10,030 --> 00:11:13,870
+برضه من مجموعة الـCorona؟ ماشي، فشو النقطة اللي
+
+124
+00:11:13,870 --> 00:11:18,920
+بدي إياها؟ النقطة اللي بدي إياها أنهأنا لما بدي
+
+125
+00:11:18,920 --> 00:11:25,700
+أقرا عن دراسة، بدي أقرا واحد بيحكي كلام معين لازم
+
+126
+00:11:25,700 --> 00:11:32,180
+أنا أكون فاهمان شو قصده، كيف عملها، شو اللي عمله،
+
+127
+00:11:32,180 --> 00:11:37,420
+يمكن كل اللي عمله غلط بغلط، يمكن، بيصير، فالآن
+
+128
+00:11:37,420 --> 00:11:41,240
+واضح، هي مدخل لللي بنناقشه هلأ
+
+129
+00:11:47,180 --> 00:11:54,280
+فإذاً يعني لما أخذنا مثال الكورونا أنا
+
+130
+00:11:54,280 --> 00:12:00,460
+قصدي فيه إنه على الأقل للآن أنا عندي ثلاث ألواء من
+
+131
+00:12:00,460 --> 00:12:05,340
+الفحوصات للكورونا ممكن أنا بفحص على الـ PCR أنا
+
+132
+00:12:05,340 --> 00:12:09,680
+بفحص على المادة الوراثية ممكن أنا أفحص على
+
+133
+00:12:09,680 --> 00:12:13,820
+البروتين تبعه لأن هدول الأثنتين إحنا بنحكي عن وجود
+
+134
+00:12:13,820 --> 00:12:19,430
+الفيروس ممكن أنا أجي أفحص علىالرد فعلي المناعة ضد
+
+135
+00:12:19,430 --> 00:12:24,810
+الفيروس مرات كثيرة في إتهابات كثيرة ما بنقدر نلقط
+
+136
+00:12:24,810 --> 00:12:31,550
+الفيروس itself صعب لأنه ممكن يعني وانت ماخده من
+
+137
+00:12:31,550 --> 00:12:39,550
+الجسم الفيروس يموت مايظلش ممكن يتحلل يعني مايظلش
+
+138
+00:12:39,550 --> 00:12:43,590
+بس الـ Immunoglobulin بظل مدة أطول فممكن الـ
+
+139
+00:12:43,590 --> 00:12:49,710
+Immunoglobulin أستخدمه عشانألاقى الإثبات إنه اللي
+
+140
+00:12:49,710 --> 00:12:55,410
+صار عند الإنسان هذا الإصابة والاتهاب بالفيروس معين
+
+141
+00:12:55,410 --> 00:13:05,190
+يعني هكذا، تمام؟ هسة الموضوع الـ «سلادين» هذولة،
+
+142
+00:13:05,190 --> 00:13:13,550
+ماشي، خلّينا نشوف شو اللي عملوه، يعني إذا أنتوا
+
+143
+00:13:13,550 --> 00:13:20,140
+شايفوا الـScreen اللي معاكي، صح؟صحيح طيب، شو اللي
+
+144
+00:13:20,140 --> 00:13:27,860
+عملوا هنا؟ منظر لما تتطلع عليه، ماشي، شو اسمه؟
+
+145
+00:13:27,860 --> 00:13:36,060
+هيك، بتتعقد، و بدك، يعني بتكون، شو اسمه؟ هيك،
+
+146
+00:13:36,060 --> 00:13:43,700
+بيصير الواحد كأنه يعني مش فاهمان ومقصورة، هيكبتفكر
+
+147
+00:13:43,700 --> 00:13:49,740
+اللي حقها عبقري ومافيش بعده ومافيش قبله وكذا وكذا،
+
+148
+00:13:49,740 --> 00:13:52,760
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+149
+00:13:52,760 --> 00:13:54,780
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+150
+00:13:54,780 --> 00:13:54,920
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+151
+00:13:54,920 --> 00:13:57,680
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+152
+00:13:57,680 --> 00:13:58,140
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+153
+00:13:58,140 --> 00:14:01,780
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+154
+00:14:01,780 --> 00:14:12,840
+وكذا
+
+155
+00:14:13,450 --> 00:14:18,270
+حكينا أنا ممكن أدور على المادة الوراثية تبعته الـ
+
+156
+00:14:18,270 --> 00:14:23,210
+DNA الـ RNA للـ Corona ممكن على الـ Protein ممكن
+
+157
+00:14:23,210 --> 00:14:27,190
+على المناعب
+
+158
+00:14:27,190 --> 00:14:37,030
+تمام؟ واضح النقطة؟ تمام، تمام النقطة طيب، الآن أنا
+
+159
+00:14:37,030 --> 00:14:46,520
+بإمكاني أفحص على كمية شغل الـ Geneفاهم علي؟ الآن
+
+160
+00:14:46,520 --> 00:14:56,000
+يعني الأصل في الـ إنه أنا في الإنسان، الإنسان DNA
+
+161
+00:14:56,000 --> 00:15:02,900
+مش RNA مش زي الكورونا، بس نفس المبدأ الـ RNA، الـ
+
+162
+00:15:02,900 --> 00:15:08,960
+DNA تبع الإنسان هو الأساس هو اللي فيه الشفرة
+
+163
+00:15:08,960 --> 00:15:17,570
+الوراثية هو اللي بيحدد، تمام؟حكينا إنه في كل خلية
+
+164
+00:15:17,570 --> 00:15:23,530
+الجينات اللي من الـ 25 ألف جين اللي في كل الـ
+
+165
+00:15:23,530 --> 00:15:28,830
+Genome الجينات اللازمة لهاي الخلية حتى تعيش حتى
+
+166
+00:15:28,830 --> 00:15:35,210
+تشتغل حتى تسدي وظيفتها هي اللي بتتم تنشيطها، تمام؟
+
+167
+00:15:35,210 --> 00:15:42,860
+فيمقابل إنه فيه جينات ثانية يتم تثبيتهايعني لازم
+
+168
+00:15:42,860 --> 00:15:47,960
+إشي معدّي معيّن من الجينات هذه تشتغل أكثر في هذه
+
+169
+00:15:47,960 --> 00:15:55,400
+الخلية خصيصًا وبالمقابل الجينات
+
+170
+00:15:55,400 --> 00:16:03,440
+الثانية، مجموعة ثانية من الجينات بتتم تثبيت شغلها
+
+171
+00:16:03,440 --> 00:16:10,060
+من ناحية إنها مش لازمة، النتيجة تبعتها، يعني في
+
+172
+00:16:10,060 --> 00:16:14,280
+هذه الخليةهذا الجين ما له الداعي فبالتالي خلاص
+
+173
+00:16:14,280 --> 00:16:20,440
+مسكر وكذا يعني مثلا الـ Hemoglobin جين اللي حكينا
+
+174
+00:16:20,440 --> 00:16:24,900
+عنه هو انت بحاجته في الـ Red Blood Cells كل خلايا
+
+175
+00:16:24,900 --> 00:16:30,460
+الجسم الثاني مسكر عليه ولا له قيمة خلايا الجينات
+
+176
+00:16:30,460 --> 00:16:37,720
+تبعات الـ Hemoglobin موجودة في الـ B و الـ T
+
+177
+00:16:37,720 --> 00:16:40,420
+-Lymphocytesللـ Immunoglobulin في الـ B
+
+178
+00:16:40,420 --> 00:16:44,640
+-Lymphocytes هي اللي بتتم تشغيلها كل قطعة الـ DNA
+
+179
+00:16:44,640 --> 00:16:48,660
+تبع الـ Immunoglobulin في كل الخلايا التانية
+
+180
+00:16:48,660 --> 00:16:56,940
+مايلها شغل، تمام؟ فالآن، شو عملوا هنا؟ اللي عملوا
+
+181
+00:16:56,940 --> 00:17:06,300
+انه، شو اسمه؟ لقوايعني أنت بدي تكون عندك طريقة
+
+182
+00:17:06,300 --> 00:17:11,560
+اللي بيسموها Idealized Gene Expression Profiling
+
+183
+00:17:11,560 --> 00:17:19,680
+Experiment شو يعني؟ يعني هنا هاي دراسة وبحث
+
+184
+00:17:19,680 --> 00:17:26,360
+افتراضي ما تخدها يعني على إنها هي نتيجة إشي حقيقي
+
+185
+00:17:26,360 --> 00:17:33,480
+عبارة عن مثال افتراضي تمام؟ معايا معتز؟معاك يا
+
+186
+00:17:33,480 --> 00:17:46,060
+دكتور؟ أه، أنا الأصل أنه في الخلية الواحدة الجين،
+
+187
+00:17:46,060 --> 00:17:53,210
+كم جين، كم لسخة منه عادةً أثنتين مثلًا، صح؟وحدة
+
+188
+00:17:53,210 --> 00:17:56,690
+على كرموزوم مثلاً إذا هذا الجين على كرموزوم واحد
+
+189
+00:17:56,690 --> 00:18:01,170
+أنا عندي نسختين من الكرموزوم واحد وبالتالي أنا
+
+190
+00:18:01,170 --> 00:18:07,290
+عندي نسختين من هذا الجين تمام هذا الجين ممكن يكون
+
+191
+00:18:07,290 --> 00:18:17,930
+صامت ولا داعي له وش اسمه وبالتالي ما له شغل تمام
+
+192
+00:18:17,930 --> 00:18:22,840
+في الحالة هذهالـ RNA لهذا الجين شماله كام نسخة راح
+
+193
+00:18:22,840 --> 00:18:32,800
+تكون منها؟ فهمت على سؤالي؟ يعني هما نسختين، يعني
+
+194
+00:18:32,800 --> 00:18:42,290
+هيطلع كمان نسختين و لا كام؟ أنا بحكي الآنالـ «DNA»
+
+195
+00:18:42,290 --> 00:18:48,110
+في الـ «نيوكلياس» والأساس ثابت وكامل لكل شيء
+
+196
+00:18:48,110 --> 00:18:51,910
+الخلايا ممكن تحتاجها طول عمرها، في كل مراحلها، في
+
+197
+00:18:51,910 --> 00:18:57,430
+كل شيء لكن كل خلية بتشغّل حسب اللي بتحتاجه خلية
+
+198
+00:18:57,430 --> 00:19:02,610
+مثلًا Red Blood Cell، ماذا تشغّل؟ «جين
+
+199
+00:19:02,610 --> 00:19:10,440
+الهيموجلومين»، صح؟أه صحيح أه اللي هي بتحتاجه مثلًا
+
+200
+00:19:10,440 --> 00:19:15,020
+الـ Red Blood Cell بتتأثر بالـ Erythropoietin الـ
+
+201
+00:19:15,020 --> 00:19:18,460
+Erythropoietin له Receptor هي لازم تكون عرض الـ
+
+202
+00:19:18,460 --> 00:19:24,200
+Receptor تبعه فالـ Red Blood Cell بحاجة لـ الـ الـ
+
+203
+00:19:24,200 --> 00:19:27,480
+الـ الـ الـ الـ الـ gene تبع الـ Receptor للـ
+
+204
+00:19:27,480 --> 00:19:32,300
+Erythropoietin أن يصير شغال هذا قبل، من أول فاهم
+
+205
+00:19:32,300 --> 00:19:37,810
+عليك كيف؟ كل خلية لهامجموعة جينات هي بحاجتها
+
+206
+00:19:37,810 --> 00:19:43,330
+تشغّلها وبقية الأشياء بتظلها صفر مالهاش شغل،
+
+207
+00:19:43,330 --> 00:19:50,230
+مالهاش داعي، مش كل خلية تنتج، كل الجينات بتعمل
+
+208
+00:19:50,230 --> 00:19:56,050
+بتطلع، كل البروتينات، لأ، كل خلية إلها إشي محدد،
+
+209
+00:19:56,050 --> 00:19:59,690
+واضح هذه النقطة؟
+
+210
+00:19:59,690 --> 00:20:05,030
+‏- واضح، هذا بتفهمني ‏- طيب، الآن، لما أنا آجي
+
+211
+00:20:05,550 --> 00:20:12,690
+نفترض أنا مثلاً لخلية العضلات بدها الأكتين والـ
+
+212
+00:20:12,690 --> 00:20:18,910
+Myosin ويلهم جينات تمام؟ وفي للـ Immunoglobulin
+
+213
+00:20:18,910 --> 00:20:24,330
+جين فيلهم جينات بحاجة الـ B-Lymphocytes إلى إن هي
+
+214
+00:20:24,330 --> 00:20:29,420
+تشغلهموالـ Red blood cells لها الـ Hemoglobin هي
+
+215
+00:20:29,420 --> 00:20:33,860
+الجين اللي بدهيها لأن الـ Hemoglobin في الـ Red
+
+216
+00:20:33,860 --> 00:20:38,400
+blood cells عشان ينقل الدم الـ Oxygen وبدنيا لما
+
+217
+00:20:38,400 --> 00:20:44,820
+أنا آجي أمسك الخلايا هذه وأشوف قداش RNA طالع من
+
+218
+00:20:44,820 --> 00:20:52,700
+الجين فاهم عليك كيف؟ فالآن لما أنا آجي أدرس خليط
+
+219
+00:20:52,700 --> 00:21:00,840
+الدمالـ RNA أو البروتين تبع الـ Hemoglobin قداش
+
+220
+00:21:00,840 --> 00:21:05,200
+بيكون منه فيه؟
+
+221
+00:21:05,200 --> 00:21:10,900
+نسخة واحدة، نسخة واحدة؟ لأ، بسألك، مش الـ DNA، الـ
+
+222
+00:21:10,900 --> 00:21:17,840
+DNA متشابه في الكل، نسخة متطابقة في الكل، كم اشتغل
+
+223
+00:21:17,840 --> 00:21:23,540
+هذا الجين وطلّق الـ RNA اللي راح يعطيني البروتين؟
+
+224
+00:21:25,550 --> 00:21:31,130
+بالنسبة للـHemoglobin Gen في خلية عضلات أو خلية
+
+225
+00:21:31,130 --> 00:21:36,050
+جلد أو خلية White Blood Cells كم بدي يكون منه
+
+226
+00:21:36,050 --> 00:21:41,710
+شغال؟ ما لهوش لازمة، مش هيكون صفر، ما لهوش لازمة
+
+227
+00:21:41,710 --> 00:21:44,730
+في الـRed Blood Cell اللي انت حكيت في الأول في
+
+228
+00:21:44,730 --> 00:21:51,770
+الـRed Blood Cell هتلاقيعشرات، مئات، ألاب من
+
+229
+00:21:51,770 --> 00:21:56,830
+الـRNA وبعدين من البروتين فاهم عليك؟ فهيكون فيه
+
+230
+00:21:56,830 --> 00:22:00,410
+تفاوت فما في باقي الخلية ما لهوش لازمة، مش هيشتغل
+
+231
+00:22:00,410 --> 00:22:06,090
+مش هيشتغل فهنا، شو اللي عملوه الدراسة هذه؟ شو اللي
+
+232
+00:22:06,090 --> 00:22:14,470
+عملت؟ أول شيء، عندهم ثمن أشخاص مثلوها عندهم أربع
+
+233
+00:22:14,470 --> 00:22:22,800
+أشخاص مثلاًعندهم سرطان معين وأخذوا الخلايا
+
+234
+00:22:22,800 --> 00:22:33,480
+السرطانية منهم ماشي وأخذوا
+
+235
+00:22:33,480 --> 00:22:42,020
+أربع أشخاص أو ثمان أشخاص مش خلايا سرطانية سواء من
+
+236
+00:22:42,020 --> 00:22:47,330
+نفس البني آدمين يعني أنت بتاخذالمرجع تبعك لنفس
+
+237
+00:22:47,330 --> 00:22:52,730
+الأشخاص بس خلايا مش سرطانية أو بتاخد إنسان طبيعي،
+
+238
+00:22:52,730 --> 00:22:58,710
+يعني ممكن هاي، ممكن هاي، ماشي الحال؟ الـ Test هنا
+
+239
+00:22:58,710 --> 00:23:08,860
+هو لموضوع قداش الجين اشتغلفاهم عليك كيف؟ قداش هذا
+
+240
+00:23:08,860 --> 00:23:13,260
+الجين شغال؟ أنا لسه هنا ما .. مش أنا بفحص بشكل
+
+241
+00:23:13,260 --> 00:23:19,080
+متخصص زي مثلًا تقولّي والله أخدت أنا panel أو
+
+242
+00:23:19,080 --> 00:23:24,840
+مجموعة هنا بيقولوا دارسين meat gene ماشي؟
+
+243
+00:23:24,840 --> 00:23:29,020
+وبيحاولوا يشوفوا قداش الجين اشتغل فأفرض الـmeat
+
+244
+00:23:29,020 --> 00:23:33,580
+gene في عندك immunoglobulin gene وهي واحد ال
+
+245
+00:23:33,580 --> 00:23:38,060
+hemoglobin gene هي اثنينالكيراتين في الجل مثلًا
+
+246
+00:23:38,060 --> 00:23:42,300
+بروتين الكيراتين في الجل برضه دخلته الأكتين
+
+247
+00:23:42,300 --> 00:23:48,100
+والمايوسين تبعان العضلات برضه أخدتهم فالآن لما أنا
+
+248
+00:23:48,100 --> 00:23:54,640
+آجي، أنا عندي أربع أو خمس جينات كل واحد في محل
+
+249
+00:23:54,640 --> 00:23:59,660
+بيشتغل وفي محل مالوش داعي فما عليك كده، فلما أنا
+
+250
+00:23:59,660 --> 00:24:06,190
+آجيأفحص قداش في اللي عنده سرطان في الخلايا
+
+251
+00:24:06,190 --> 00:24:12,690
+السرطانية قداش كل جين يا إما بيشتغل أكثر من
+
+252
+00:24:12,690 --> 00:24:19,390
+الاعتيادي أو أقل من الاعتيادي فانت هنا يعني هدولة
+
+253
+00:24:19,390 --> 00:24:23,050
+هنا اللي بيحكولك عليك كل واحد من هالخطوط هدولة
+
+254
+00:24:23,050 --> 00:24:27,410
+العينات شايف وين individual sample profile شفتها
+
+255
+00:24:27,410 --> 00:24:35,210
+أول واحدةهنا درسوا عشرة في عشرة ميث جين وبيدوروا
+
+256
+00:24:35,210 --> 00:24:39,490
+على الـ «مسنجر RNA» أو على البروتين الناتج عنه
+
+257
+00:24:39,490 --> 00:24:47,150
+وبيقدروا يشوفوا هل الـ «جين» هذا هو شغال أكثر من
+
+258
+00:24:47,150 --> 00:24:53,110
+الاعتيادي أو أقل من الاعتيادي وهنا الـ… أنت شايف
+
+259
+00:24:53,110 --> 00:24:56,810
+هنا؟ أنا بأشهر لك هنا Individual Sample Profile
+
+260
+00:24:56,810 --> 00:25:03,940
+عظيمهذه أول واحدة اللي
+
+261
+00:25:03,940 --> 00:25:07,840
+كانت بيلاك عليها expression level العزاوية اللي
+
+262
+00:25:07,840 --> 00:25:16,520
+تحت هذه إذا أصفر معناته مقارنة بغيره مقارنة بالـ
+
+263
+00:25:16,520 --> 00:25:21,140
+Normalسواء Normal Individual أو Normal Cell في
+
+264
+00:25:21,140 --> 00:25:28,700
+الإنسان نفسه المعدل التنشيط هذا الـGene هنا زي وزي
+
+265
+00:25:28,700 --> 00:25:37,890
+غير الخلايا الثانية هنا أربع أضعاف الإنتاجوهنا ربع
+
+266
+00:25:37,890 --> 00:25:42,270
+الإنتاج يعني هنا لما نكون إشي أحمر معناته هذه
+
+267
+00:25:42,270 --> 00:25:47,270
+الخلية اللي أنا أخدتها ما صنعت هذا الـ الـ
+
+268
+00:25:47,270 --> 00:25:52,590
+البروتين هذا الجيل في هذه الخلية مش شغال، مالوش
+
+269
+00:25:52,590 --> 00:25:57,770
+قيمة وهنا هذا الإشي اللي شغلته كثير اللي لونه
+
+270
+00:25:57,770 --> 00:26:04,610
+أخضر، تمام؟ معايا للآن؟ ‏- تمام ‏- للآن شو
+
+271
+00:26:04,610 --> 00:26:15,420
+بيعملوا؟هنا لكل إنسان من العشر أو ثمان حالات لميت
+
+272
+00:26:15,420 --> 00:26:23,320
+جين وعرفنا لكل واحد شو عنده، ماشي؟ وهي يعني القصد
+
+273
+00:26:23,320 --> 00:26:28,040
+في الموضوع أنه أنت عندك كمبيوتر وجهاز قوي كثير
+
+274
+00:26:28,040 --> 00:26:32,520
+بقرا الأشياء بسرعة و بقارنها ببعض و بطلّعلك الصورة
+
+275
+00:26:32,520 --> 00:26:38,810
+هذهالآن هذولة ميت جين بس لسه أنا ماعندي تصور في
+
+276
+00:26:38,810 --> 00:26:44,070
+المرض هذا السرطان من هذا النوع أنه جينات اللي
+
+277
+00:26:44,070 --> 00:26:49,110
+مرتبطة بوجود هذا النوع من السرطان إنها أكثر شو
+
+278
+00:26:49,110 --> 00:26:57,290
+بقوم بعمل؟ بعدين بجيب نفس المعلومات اللي هنا الـ
+
+279
+00:26:57,290 --> 00:27:02,270
+Individual Sample Profile اللي طلعتها بالأولبعملها
+
+280
+00:27:02,270 --> 00:27:11,370
+إنه بعيد ترتيبها بهذا الشكل بقص يعني نفس المعلومة
+
+281
+00:27:11,370 --> 00:27:21,490
+يعني إذا تنتبه Sample رقم واحد شوفتها؟ آه بدل
+
+282
+00:27:21,490 --> 00:27:27,730
+ما هي بالمربعات أسكتها طولة خليك معاه قليل شوية
+
+283
+00:27:27,730 --> 00:27:34,240
+Sample رقم واحدفهذه المي اللي هنا اللي بشكل مربع
+
+284
+00:27:34,240 --> 00:27:40,360
+فردناهم بهذا الشكل فأول نتيجة لأول زاوية شو كانت
+
+285
+00:27:40,360 --> 00:27:48,160
+أحمر ولا أخضر ولا أصفر؟ أحمر فهنا أول واحدة حمرة
+
+286
+00:27:48,160 --> 00:27:55,220
+آخر واحدة من هذه الجهة حطينا هنا أصفر وهنا حطينا
+
+287
+00:27:55,220 --> 00:28:00,950
+أخضر غلط يعني بعتبر أنه بضحكوا عليناماشي، بس الأصل
+
+288
+00:28:00,950 --> 00:28:05,070
+أنه يعني فرضوا النتيجة اللي من الـ Individual
+
+289
+00:28:05,070 --> 00:28:12,010
+sample حطوه جنب بعض بهذا الشكل، تمام؟ والأصل ترتيب
+
+290
+00:28:12,010 --> 00:28:17,030
+الجينات، واحد، اتنين، تلاتة، لمية جين، هيك رتبوه
+
+291
+00:28:17,030 --> 00:28:25,990
+بهذا الشكل، ماشي الحال؟ أما في عندك أنت العينات
+
+292
+00:28:25,990 --> 00:28:31,660
+من السرطانوعينات من خلايا طبيعية أو عينات من مرضى
+
+293
+00:28:31,660 --> 00:28:38,280
+السرطان وعينات من بناء آدم طبيعي بالأخير، بالنسبة
+
+294
+00:28:38,280 --> 00:28:41,340
+لتقييم
+
+295
+00:28:41,340 --> 00:28:51,700
+الموضوع أنه أنا بقيم بالنسبة للسرطانات بالنسبة
+
+296
+00:28:51,700 --> 00:29:00,590
+للجينات من واحد لميةما هو الشيء الذي يشغّل هذا
+
+297
+00:29:00,590 --> 00:29:04,390
+الجين من السرطان،
+
+298
+00:29:04,390 --> 00:29:11,810
+وهو اللون الأخضر اللي عنده سرطان معين أنه جين
+
+299
+00:29:11,810 --> 00:29:18,270
+اللون أحمر، يعني ما بيشتغلش فوجود الاختلالات هذه
+
+300
+00:29:18,960 --> 00:29:26,000
+بتأشر لك وين المسبب لهذا السرطان كيف بغير شغل
+
+301
+00:29:26,000 --> 00:29:31,240
+الجينات في هذه العينة وفي هذه الدراسة فهم عليك
+
+302
+00:29:31,240 --> 00:29:40,140
+كيف؟ فهذه دراسة افتراضية إحنا
+
+303
+00:29:40,140 --> 00:29:45,920
+هنا بندرس الـ Gene Expression Profiling من ثمن
+
+304
+00:29:45,920 --> 00:29:52,940
+عيناتو100 جين أنا بدور عليهم فاهم عليك كيف؟ ومع
+
+305
+00:29:52,940 --> 00:29:56,820
+ذلك، ما هي الـ100 جينات؟ وليش بالضبط أنا سويتهم؟
+
+306
+00:29:56,820 --> 00:30:01,420
+وكذا، يعني يمكن صعب، وما بكونوش لسه يعرفوا يعني
+
+307
+00:30:01,420 --> 00:30:08,460
+طريقة تصميم هذه الدراسة بتكون علشان يعني يعني
+
+308
+00:30:08,460 --> 00:30:16,140
+بتكون علشانباستخدام الـ Sequencer أو بيسموها الـ
+
+309
+00:30:16,140 --> 00:30:21,700
+Second Generation Sequencer عبارة عن أجهزة بتقس
+
+310
+00:30:21,700 --> 00:30:26,860
+لها، بتقرا لك الـ DNA بشكل صاروخي، يعني سريع جدا،
+
+311
+00:30:26,860 --> 00:30:32,600
+و عندك معلومات كتيرة و بدك بعدين تحاول تفهمها،
+
+312
+00:30:32,600 --> 00:30:38,580
+فمعناك كيف؟فلما تقول في السرطان اللي فلاني من
+
+313
+00:30:38,580 --> 00:30:41,660
+النوعية اللي فلانية الجين اللي فلاني والجين اللي
+
+314
+00:30:41,660 --> 00:30:48,400
+فلاني يعني هنا ما نقدر نقوله إذا بتلاحظ سرطان من
+
+315
+00:30:48,400 --> 00:30:53,760
+النوع A ويمكن بدل tumor B ممكن تكون الإنسان طبيعي
+
+316
+00:30:53,760 --> 00:31:00,300
+فلما تقوم بتعمل المقارنة واضح إن مثلا الجين رقم
+
+317
+00:31:00,300 --> 00:31:07,230
+واحد اللي عندهم السرطان Aشوف العينات 2 و3 و6 و8،
+
+318
+00:31:07,230 --> 00:31:13,690
+الجين هذا شغال كثير، بينما اللي ماعنده مش سرطان أو
+
+319
+00:31:13,690 --> 00:31:21,910
+سرطان ثاني، هذا الجين كان مش شغال ومثبت كثير، يعني
+
+320
+00:31:21,910 --> 00:31:27,990
+بنرتبهم بهذا الشكل، اللي هناهو أنا شغال كثير ومش
+
+321
+00:31:27,990 --> 00:31:32,790
+شغال وهنا بالعكس هون هاي الجينات هون شغال كثير
+
+322
+00:31:32,790 --> 00:31:38,530
+وهون مش شغالة يعني تقدر تستنتج من الدراسة هذه أنه
+
+323
+00:31:38,530 --> 00:31:43,770
+بتقول مثلا اللي عنده tumor A الجين رقم واحد ورقم
+
+324
+00:31:43,770 --> 00:31:50,490
+خمس وعشرين ورقم مثلا سبعة وعشرين هدولة بكونوا أكثر
+
+325
+00:31:50,490 --> 00:31:55,840
+بكثير من الـ Controlوالجينات الأخرى، رقم كذا ورقم
+
+326
+00:31:55,840 --> 00:32:02,960
+كذا ورقم كذا مثبتة أكثر بكثير من الـ Control «هيك
+
+327
+00:32:02,960 --> 00:32:09,280
+بدك تعيد، بتعيد، بتعيد» فهي يعني صورة بتعقد وإذا
+
+328
+00:32:09,280 --> 00:32:15,200
+ما كان الشرح عليها واضح كثير، ما لها قيمة يعني
+
+329
+00:32:15,200 --> 00:32:22,100
+واحد عنده أرقام وبيعرضها وما لهاش قيمة أو إنه ممكن
+
+330
+00:32:22,100 --> 00:32:22,480
+إذا
+
+331
+00:32:25,760 --> 00:32:29,980
+الارتباط بين هذا النوع من السرطان مع شغل هذا الجين
+
+332
+00:32:29,980 --> 00:32:35,140
+إذا قوي كثير، المفروض يكون مؤشر إنك تروح تدرسه
+
+333
+00:32:35,140 --> 00:32:38,620
+أكثر، اروح أدور شو طب البروتين اللي بتطلع هذا
+
+334
+00:32:38,620 --> 00:32:44,720
+الجين؟ شو دوره؟ ليش بيخليه؟ شو وظيفته؟ هيك بنقدم
+
+335
+00:32:44,720 --> 00:32:48,780
+الطب و بندرس هذه الموضوع أتأمل أني أكون شرحت
+
+336
+00:32:48,780 --> 00:32:56,130
+الصورة هذه، اللي هي أنه يعني بدكيكون أول شيء عندك
+
+337
+00:32:56,130 --> 00:33:00,450
+القالة اللي بتعمل هذا الاشي ويكون العينات أخدتها
+
+338
+00:33:00,450 --> 00:33:08,550
+بشكل سليم وبعدين تحاول تدرس شو العلاقة بين النقاط
+
+339
+00:33:08,550 --> 00:33:13,870
+هذه الطريق
+
+340
+00:33:13,870 --> 00:33:18,010
+اللي سوناه
+
+341
+00:33:18,010 --> 00:33:20,450
+من قبل هو
+
+342
+00:33:23,350 --> 00:33:32,090
+يعني الـ Gene Expression Profiling يعني عن طريق
+
+343
+00:33:32,090 --> 00:33:36,530
+مثلًا الـ Messenger RNA عن طريق يمكن البروتين
+
+344
+00:33:36,530 --> 00:33:41,270
+الناتج بس في الغالب عن طريق الـ Messenger RNA أنا
+
+345
+00:33:41,270 --> 00:33:51,350
+بعمل، شو اسمه؟ بشوف كمية شغل هذا البروتين، هذا الـ
+
+346
+00:33:51,350 --> 00:33:57,310
+Geneهل هو فاعل وشغّال أو خامل ولم يكن له قيمة؟ لم
+
+347
+00:33:57,310 --> 00:34:02,110
+يتم استفادة منه؟ لم يكن له دور في هذه الخلايا؟
+
+348
+00:34:05,770 --> 00:34:10,990
+فالطريقة الأولى ما حددوش عندى بالظبط شو هو الـ
+
+349
+00:34:10,990 --> 00:34:15,230
+«جين إكسبريشن» شو اسمه الـ «جين إكسبريشن» الـ «جين
+
+350
+00:34:15,230 --> 00:34:15,570
+إكسبريشن» الـ «جين إكسبريشن» الـ «جين إكسبريشن»
+
+351
+00:34:15,570 --> 00:34:15,630
+الـ «جين إكسبريشن» الـ «جين إكسبريشن» الـ «جين
+
+352
+00:34:15,630 --> 00:34:15,930
+إكسبريشن» الـ «جين إكسبريشن» الـ «جين إكسبريشن»
+
+353
+00:34:15,930 --> 00:34:19,550
+الـ «جين إكسبريشن» الـ «جين إكسبريشن» الـ «جين
+
+354
+00:34:19,550 --> 00:34:26,850
+إكسبريشن» الـ «جين إكسبريشن» الـ «جين
+
+355
+00:34:26,850 --> 00:34:31,690
+إكسبريشن»
+
+356
+00:34:31,690 --> 00:34:38,970
+الللورقة العلمية اللي هم كاتبينها مفروض يعطوك مرجع
+
+357
+00:34:38,970 --> 00:34:46,870
+بيحدد بالضبط كيف أملوا الفحص هذا، «شو الجينات
+
+358
+00:34:46,870 --> 00:34:53,970
+بالتفصيل؟» بحلوك لمرجع آخر بيشرحوا فيه «شو هذه
+
+359
+00:34:53,970 --> 00:35:02,570
+الأخضر والأصفر والأحمر اللي سووها»بنفس المبدأ بنفس
+
+360
+00:35:02,570 --> 00:35:11,110
+الطريقة ممكن أنا أعمل يعني هنا باستخدام microarray
+
+361
+00:35:11,110 --> 00:35:19,090
+analysis بجيب series of tumors ماشي مثلا نفترض أنا
+
+362
+00:35:19,090 --> 00:35:25,400
+هنا ناس عندهم سلطان الرئة سلطان الرئةطبعاً ممكن
+
+363
+00:35:25,400 --> 00:35:29,980
+يكون مش من الرئة نفسها ممكن من محل ثاني في الجسم،
+
+364
+00:35:29,980 --> 00:35:33,820
+من المعدة، من القولون، طارت على الرئة، بيصير بس
+
+365
+00:35:33,820 --> 00:35:38,240
+ممكن تكون سرطان رئة مثلاً في small cell carcinoma
+
+366
+00:35:38,240 --> 00:35:43,520
+في non-small cell carcinoma في large cell، في
+
+367
+00:35:43,520 --> 00:35:48,120
+squamous cell، في adenocarcinoma كل واحد من هدول
+
+368
+00:35:48,120 --> 00:35:55,920
+نوع من السرطانات من سرطانات الرئتينطيب، أنا مثلاً
+
+369
+00:35:55,920 --> 00:36:01,940
+أخذت ناس عندهم Small Cell Carcinoma مظهرياً
+
+370
+00:36:01,940 --> 00:36:10,440
+لما أنا أخذ العينة بتكون هاي Small Cell Carcinoma،
+
+371
+00:36:10,440 --> 00:36:16,620
+ماشي؟ باللاقي لما نيجي احنا نعالج المرضى هذولة،
+
+372
+00:36:16,620 --> 00:36:23,000
+نتعامل معهمبتلاقي والله في ناس يعني كأن السرطان
+
+373
+00:36:23,000 --> 00:36:29,840
+حميد أكثر، يعني بطيء، بتلاقي مثلًا والله طول، وفي
+
+374
+00:36:29,840 --> 00:36:36,540
+ناس بتلاقي شديد جدًا، بتلاقي السرطان خلال أسابيع
+
+375
+00:36:36,540 --> 00:36:40,640
+أو أشهر قضى على الإنسان، قضى على المريض، ليش هيك
+
+376
+00:36:40,640 --> 00:36:49,000
+اختلفوا؟ فافرض إنه أنامثلًا، عندي مجموعة مثلًا ناس
+
+377
+00:36:49,000 --> 00:36:54,460
+عندهم سرطان «small cell carcinoma» وقدرت أنا أميز
+
+378
+00:36:54,460 --> 00:37:01,540
+مجموعتين ناس السرطان سريق كثير كثير كثير وناس
+
+379
+00:37:01,540 --> 00:37:08,280
+السرطان بطيء فبحاول أفهم ليش الاختلاف في السلوك
+
+380
+00:37:08,280 --> 00:37:16,090
+فهنا أنا أخدت مجموعة سرطاناتوعندي إشي ثاني استطعت
+
+381
+00:37:16,090 --> 00:37:20,830
+من خلاله أقسمهم لمجموعة cluster A و cluster B يعني
+
+382
+00:37:20,830 --> 00:37:26,190
+هدولة والله B اللي هم بطيئين و cluster A سريقين
+
+383
+00:37:26,190 --> 00:37:33,950
+جدا وخبثين مثلا السرطان تبعهمماشي هنا الأحمر هو
+
+384
+00:37:33,950 --> 00:37:40,010
+اللي يعني هاي بيتكلموا على أنه المرضى هدولة ال
+
+385
+00:37:40,010 --> 00:37:48,550
+survival يعني عيشتهم ويعني قداش سرعة السلطان يخدع
+
+386
+00:37:48,550 --> 00:37:53,320
+المريض اللي عنده من النوع الأحمربتلاقي الناس
+
+387
+00:37:53,320 --> 00:37:59,300
+بتوفوا بحيث إنه أنا بالأشهر خلال عشر سنين هو أنا
+
+388
+00:37:59,300 --> 00:38:03,760
+ماضلش أربعين بالمية من الناس بينما اللي عنده من
+
+389
+00:38:03,760 --> 00:38:10,540
+الـCluster B بعد عشر سنين مثلا تسعين بالمية من
+
+390
+00:38:10,540 --> 00:38:17,300
+الناس لسه حياة، ما ماتوا، فإذا عندي أنا يعني
+
+391
+00:38:17,300 --> 00:38:22,850
+مؤشرات بهذه الطريقةوبعدين بعمل microarray analysis
+
+392
+00:38:22,850 --> 00:38:32,790
+هذه أسلوب الـ «microarray» إنك أنت، شو اسمه؟ بتشوف
+
+393
+00:38:32,790 --> 00:38:43,730
+يعني اللي هو وجود gene بشكل معين بـ mutation معينة
+
+394
+00:38:43,730 --> 00:38:48,930
+أو بـ sequence معينة، درجة وجودهوبتشوف الأخضر
+
+395
+00:38:48,930 --> 00:38:55,430
+والأحمر الأخضر إنه موجود بدرجة أكبر والأحمر موجود
+
+396
+00:38:55,430 --> 00:39:03,610
+بدرجة أقل فأنا هنا بصير أقول والله مجموعة الجينات
+
+397
+00:39:03,610 --> 00:39:08,090
+هذه اللي عندهيا بالشكل هذا لو من أول يوم بعدين
+
+398
+00:39:08,090 --> 00:39:12,870
+يعني بعد ما تطلع النتيجة هذه ويصير هذا الـ Test
+
+399
+00:39:12,870 --> 00:39:20,000
+أنا ممكن أعمله كل ما تجيني حاليمثلًا، سرطان Small
+
+400
+00:39:20,000 --> 00:39:25,020
+Cell Carcinoma تبع الرئتين باجي بعملهم الفحص هذا
+
+401
+00:39:25,020 --> 00:39:29,520
+وبشوف شكل الإنسان هذا زي الـCluster A و لا
+
+402
+00:39:29,520 --> 00:39:34,040
+الـCluster B والله طلع زي الـCluster B، وهو هذا
+
+403
+00:39:34,040 --> 00:39:41,240
+الإنسان إن شاء الله راح يكون التقدم للسرطان بطيء
+
+404
+00:39:41,570 --> 00:39:46,690
+ويمكن مافيش داعي أعالجه وماشدش عليه كثير واتركه
+
+405
+00:39:46,690 --> 00:39:51,130
+بينما بشوف واحد الـ Cluster A لأ بقول هذا إنسان
+
+406
+00:39:51,130 --> 00:39:57,270
+راح يكون مرضه شديد ولازم أدخل بقوة شديدة لازم
+
+407
+00:39:57,270 --> 00:40:01,190
+أعطيه كيماوي لازم أعطيه شعار لازم أعمله عمليات
+
+408
+00:40:01,190 --> 00:40:07,290
+لازم أسوي له كده بتغير سلوكي كطبيب تجاه المريض حسب
+
+409
+00:40:07,290 --> 00:40:16,200
+شكلالـ Microarray Analysis وهذا كله بعد ما يعني
+
+410
+00:40:16,200 --> 00:40:21,480
+أنا اتوصلت للنتيجة هذه من خلال الدراسة هذه أظن
+
+411
+00:40:21,480 --> 00:40:28,240
+أتمن أنه واضح يا معتز فيها إشي هاتف بمعرفة كيف هي
+
+412
+00:40:28,240 --> 00:40:36,780
+ترتيبها وهنا يعني يعني الـ الـ النقطتين، الفلاف
+
+413
+00:40:36,780 --> 00:40:42,710
+اللي أناتركز عليهم وتنتبه عليهم في هذا الوضع أنت
+
+414
+00:40:42,710 --> 00:40:52,650
+هنا يعني أول شي بالنسبة للنقطة هذه أنه أنا أول شي
+
+415
+00:40:52,650 --> 00:40:57,350
+عندي سرطان مثلا واستطعت منه أن ألاقي أن فيه
+
+416
+00:40:57,350 --> 00:41:03,030
+مجموعتين واحد سلوكه حميد واحد سلوكه خبيث واستطعت
+
+417
+00:41:03,030 --> 00:41:07,610
+من خلالالتقسيم المجموعتين هذه إن أدرس الـ DNA
+
+418
+00:41:07,610 --> 00:41:12,570
+تبعهم باستخدام الـ Microarray Analysis لإيش معين
+
+419
+00:41:12,570 --> 00:41:18,030
+لقيت في أشياء تشتغل أكثر وفي أشياء ما بتشتغلش
+
+420
+00:41:18,030 --> 00:41:25,270
+فاللي عنده شكل معينزي الـ Cluster A بهذا الشكل هذا
+
+421
+00:41:25,270 --> 00:41:30,210
+الإنسان راح يكون مستقبله أسود ونتيجته صعبة راح
+
+422
+00:41:30,210 --> 00:41:34,790
+تكون الـ Cluster B لأ راح يكون هذا Benign وحميد
+
+423
+00:41:34,790 --> 00:41:41,370
+وأنا بإمكاني أصبر وأستنى فربطوا هذا الموضوع بالـ
+
+424
+00:41:41,370 --> 00:41:49,520
+Survivalوبقاء الحالات لمدة متابعوهم سنين طويلة عشر
+
+425
+00:41:49,520 --> 00:41:54,080
+سنين أو أحداشر سنة هنا ولقوا هذه النتيجة فبالتالي
+
+426
+00:41:54,080 --> 00:41:59,380
+هذه الدراسة تقدر تساعدني في المستقبل كيف أتعامل مع
+
+427
+00:41:59,380 --> 00:42:05,360
+المرضى هذول من هذا النوع فهذه الأشياء مواضيع معقدة
+
+428
+00:42:05,360 --> 00:42:11,240
+هل هي ممكنة في كل مكان في العالم وسهل الواحد
+
+429
+00:42:11,240 --> 00:42:16,460
+يعملها؟ لأوبعدين يعني حتى لو قلت مثلا والله لقوا
+
+430
+00:42:16,460 --> 00:42:21,760
+هذه النتيجة في أمريكا ماشي تيجي تقول مثلا والله في
+
+431
+00:42:21,760 --> 00:42:26,060
+الأردن أنا بدي أجعل أكرر نفس التجربة واستفيد من
+
+432
+00:42:26,060 --> 00:42:31,080
+هذا الـ من هذه النتيجة تماما لمرضاي يمكن ما ينطبق
+
+433
+00:42:31,080 --> 00:42:38,430
+عليهم وما تفيدكماشي، إن شاء الله أنه يضحك، بس يعني
+
+434
+00:42:38,430 --> 00:42:44,750
+هذه أشياء معقدة وبدك تقراها شويه شويه حتى تستوعب
+
+435
+00:42:44,750 --> 00:42:52,130
+شو اللي بكتبوا عنه ومافيش زي إنك أنت تجربها بإيدك
+
+436
+00:42:52,130 --> 00:43:00,100
+أو تقرا دراسة عنهاوتغوص في آلية
+
+437
+00:43:00,100 --> 00:43:03,880
+عمل الدراسة الـ Methodology شو بالضبط سووا، كيف
+
+438
+00:43:03,880 --> 00:43:08,360
+عملوها، شو اشتراطاتهم، شو كذا مرات كثير هذه
+
+439
+00:43:08,360 --> 00:43:14,440
+الأشياء بتكون مالهاش قيمة يعني واحد عنده مصاري
+
+440
+00:43:14,440 --> 00:43:19,220
+وعمل تجربة وبده يطلع نتيجة فالعالم بتفيد، بتفدش،
+
+441
+00:43:19,220 --> 00:43:23,380
+بيقدروا الناس اللي بعده يطلعوا نفس النتيجة ولا لا
+
+442
+00:43:25,870 --> 00:43:33,070
+ماشي، في أسئلة، في إشي محدد مش واضح يا معتز أو يا
+
+443
+00:43:33,070 --> 00:43:40,150
+كريم أو أي حد أو .. ممكن تحل سؤال الـ E-World
+
+444
+00:43:40,150 --> 00:43:48,890
+تختار، سؤال من ملف الـ E-World آه، أي سؤال؟ الرقم
+
+445
+00:43:48,890 --> 00:43:59,370
+28اللي هو يُاسم ليه «Kaplan» ولا «Genetics»؟ لأ
+
+446
+00:43:59,370 --> 00:44:08,930
+ليش «Kaplan» طيب الـ «Genetics» سؤال رقم 28 الأول
+
+447
+00:44:08,930 --> 00:44:16,270
+الأوائل ولا الفواني؟ الـ «Log» الأول 28 الـ «Log»
+
+448
+00:44:16,270 --> 00:44:19,070
+الأول طيب، هاي 26
+
+449
+00:44:24,760 --> 00:44:38,020
+27 هاي 28 طيب خلّيني أعمل share هاي
+
+450
+00:44:38,020 --> 00:44:45,620
+new share تقدر
+
+451
+00:44:45,620 --> 00:44:51,080
+تقرأ السؤال يا كريم أه
+
+452
+00:44:51,080 --> 00:44:53,360
+بقرأ بجد طيب يلّا
+
+453
+00:44:59,290 --> 00:45:03,330
+أمرأة عمرها 19 عامة كانت تتعامل مع مخاطرات
+
+454
+00:45:03,330 --> 00:45:09,990
+تونيكية. في السنوات السابقة، كانت أيضًا تتعامل مع
+
+455
+00:45:09,990 --> 00:45:14,410
+مخاطرات إيراكية في أسطولها وعينها، وكذلك بخاطرات
+
+456
+00:45:14,410 --> 00:45:19,750
+عضوية. الفتاة كانت لديها عائلات مختلفة من الخارج،
+
+457
+00:45:19,750 --> 00:45:24,830
+مع إشعارات مشابهة، ومحاولة التجارب تتعامل معها،
+
+458
+00:45:24,830 --> 00:45:28,210
+وكانت تتعامل معها في الجزء الأسفل وفي البوابة
+
+459
+00:45:28,210 --> 00:45:34,280
+المساعدة.Skeletal muscle biopsy shows رجد Red
+
+460
+00:45:34,280 --> 00:45:37,380
+appearing muscle fibers.Further analysis reveals
+
+461
+00:45:37,380 --> 00:45:39,660
+that the patient's symptoms are due to mainly
+
+462
+00:45:39,660 --> 00:45:44,220
+extra nuclear DNA.Which of the following degree is
+
+463
+00:45:44,220 --> 00:45:47,980
+most likely to represent this patient's family
+
+464
+00:45:47,980 --> 00:45:51,380
+history؟طيب،
+
+465
+00:45:51,380 --> 00:45:58,420
+أسا، شوف، خلّينا نحاول يعني مرات كتير لأشياء زي
+
+466
+00:45:58,420 --> 00:46:05,700
+هيكأنا يمكن من حالي مش شايف الـD بشكل واضح، ماشي
+
+467
+00:46:05,700 --> 00:46:09,540
+في
+
+468
+00:46:09,540 --> 00:46:14,340
+الصورة التانية موجود الـD؟ آه، بنزل عليها بعد
+
+469
+00:46:14,340 --> 00:46:18,460
+شوية، بس خلّينا نشوف، بس شو اللي عرفناه من هذه
+
+470
+00:46:18,460 --> 00:46:25,620
+القصة؟ أول شيء، يعني أنا حكيت من قبل إنه تفاصيل
+
+471
+00:46:25,620 --> 00:46:32,740
+المادة العلميةيعني كمرض وشو اسم المرض هذا، يعني هي
+
+472
+00:46:32,740 --> 00:46:40,640
+عندها خلل في الأعصاب، ماشي، عندها نوبات صراع، يعني
+
+473
+00:46:40,640 --> 00:46:43,430
+tonic-clonic seizureاللي هم يعني
+
+474
+00:46:43,430 --> 00:47:05,110
+الـ………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………
+
+475
+00:47:12,010 --> 00:47:19,230
+وعندها بيصير الإصابة
+
+476
+00:47:19,230 --> 00:47:27,410
+تبعتها مش بس عصبية حركية لأ عصبية حسية فـ Decrease
+
+477
+00:47:27,410 --> 00:47:33,530
+sensation ماشي والمأثرة غير الـ Muscle weakness
+
+478
+00:47:33,530 --> 00:47:39,570
+أنه لما تمشي الإنسان زي لما يكون مثلًاإذا بتشوف
+
+479
+00:47:39,570 --> 00:47:43,890
+واحد سكران، واحد عنده بعث على العضلات، بيكون مفحج
+
+480
+00:47:43,890 --> 00:47:49,110
+رجليه كتير، بيحاول أنه عشان يحفظ توازنه، بيكون
+
+481
+00:47:49,110 --> 00:47:56,550
+إجراءه واسعات فلقينا إنه في عندها muscle weakness
+
+482
+00:47:56,550 --> 00:48:02,130
+وأخدوا من الـMuscle Biopsy، لكوا في عندها مشكلة،
+
+483
+00:48:02,130 --> 00:48:10,950
+ماشيولمّا سوّينا لها الـ… لما
+
+484
+00:48:10,950 --> 00:48:15,370
+سوّينا لها الـMuscle Biopsy، ماشي أو آسف، لما
+
+485
+00:48:15,370 --> 00:48:20,310
+سوّينا لها الـGenetic الدراسة، وين المشكلة كانت يا
+
+486
+00:48:20,310 --> 00:48:23,330
+كريم؟
+
+487
+00:48:23,330 --> 00:48:27,350
+عشان
+
+488
+00:48:27,350 --> 00:48:31,810
+سؤال بس، عشان جدًالمّا كتبوا لك في السؤال في
+
+489
+00:48:31,810 --> 00:48:35,470
+الـSTEM «معلومات أخرى يظهر أن الشيء اللي يحدث في
+
+490
+00:48:35,470 --> 00:48:35,870
+الشيء اللي يحدث في الشيء اللي يحدث في الشيء اللي
+
+491
+00:48:35,870 --> 00:48:36,350
+يحدث في الشيء اللي يحدث في الشيء اللي يحدث في
+
+492
+00:48:36,350 --> 00:48:39,230
+الشيء اللي يحدث في الشيء اللي يحدث في الشيء اللي
+
+493
+00:48:39,230 --> 00:48:39,930
+يحدث في الشيء اللي يحدث في الشيء اللي يحدث في
+
+494
+00:48:39,930 --> 00:48:40,150
+الشيء اللي يحدث في الشيء اللي يحدث في الشيء اللي
+
+495
+00:48:40,150 --> 00:48:40,790
+يحدث في الشيء اللي يحدث في الشيء اللي يحدث في
+
+496
+00:48:40,790 --> 00:48:41,330
+الشيء اللي يحدث في الشيء اللي يحدث في الشيء اللي
+
+497
+00:48:56,860 --> 00:49:03,600
+فهي مثال على «Mitochondrial Disease» ماشي، شو الـ
+
+498
+00:49:03,600 --> 00:49:07,160
+Characteristics بـ degree تبعت الـ «Mitochondrial
+
+499
+00:49:07,160 --> 00:49:11,900
+Disease»؟ الـ «Mitochondrial» ينتقل إلى معلوم
+
+500
+00:49:11,900 --> 00:49:16,600
+لأبناء فقط، بس ورث الـ Female لـ الـ «G» اللي
+
+501
+00:49:16,600 --> 00:49:21,860
+وراها أكثر من هيك، بأثر على ال «Males» ولا الـ
+
+502
+00:49:21,860 --> 00:49:26,210
+«Females»؟بتصل على اتنين، ولكن ما بنتقل من جيل
+
+503
+00:49:26,210 --> 00:49:28,370
+لجيل إلا من الأم، بس الأم اللي بتولّي ثمانية
+
+504
+00:49:28,370 --> 00:49:34,950
+كندرية الـDNA طيب، فإنتي هسة الـA، بنفع ولا بنفعش؟
+
+505
+00:49:34,950 --> 00:49:39,710
+الـA لأ أكيد، لإنه في على الشمال الأب موارثه لإبنه
+
+506
+00:49:39,710 --> 00:49:46,700
+آه، الأب ما بيصير يعني إنسان أب يكون هو المصابغلط
+
+507
+00:49:46,700 --> 00:49:50,220
+إنه يعطي .. بس على أقل إنه males و females
+
+508
+00:49:50,220 --> 00:49:54,380
+affected okay it goes with it يعني تمشي معاهم، بس
+
+509
+00:49:54,380 --> 00:50:00,860
+بما إنه الأب أعطى ولاده، هذا مش هو ال issue الصحيح
+
+510
+00:50:00,860 --> 00:50:05,880
+الـB صح ولا مش صح؟ الـB is autosomal recessive،
+
+511
+00:50:05,880 --> 00:50:11,360
+فبرضه بره نعم الـB is autosomal recessive، فبرضه
+
+512
+00:50:11,360 --> 00:50:13,660
+بره أه he skipped generation لإنه في skip
+
+513
+00:50:13,660 --> 00:50:19,500
+generation، ما بزبطالـ C برضه فيه مشكلة الأب أعطى
+
+514
+00:50:19,500 --> 00:50:26,200
+بناته ما بيثبت ماشي أشوف الـ D و أنا ننزل تحت الـ
+
+515
+00:50:26,200 --> 00:50:34,500
+D الأم أعطت أولادها و بناتها ماعطتهمش ما بيصير
+
+516
+00:50:34,500 --> 00:50:44,080
+يعني و الأم هي الـ affected الـ E شو رأيك فيه الجد
+
+517
+00:50:44,080 --> 00:50:52,500
+مفاعلأعطت ولدها وبناتها كلها ولدتك برضه وعطيتها؟
+
+518
+00:50:52,500 --> 00:50:57,680
+أنا ماعطاش إشي، بينما البنات هم اللي بعطيه وغانا
+
+519
+00:50:57,680 --> 00:51:05,320
+يعني أقرب إشي لهم شو أنه الحل E فخليني نشوف كتبنا
+
+520
+00:51:05,320 --> 00:51:12,710
+الإجابة الـE، بس أنت يعني الفكرةبدّك تقرأ سم
+
+521
+00:51:12,710 --> 00:51:18,330
+السؤال شويه شويه براواقة وتحاول تفهم الأشياء اللي
+
+522
+00:51:18,330 --> 00:51:27,090
+معطينا فيها لو تيجي تنتبه للسؤال مرة ثانية الوصف
+
+523
+00:51:27,090 --> 00:51:33,060
+الأول كله ملوش قيمةيعني بيخربطوا الواحد إنه
+
+524
+00:51:33,060 --> 00:51:36,000
+«Tonic» «Lonic» وكان عنده كده وكان عنده كده
+
+525
+00:51:36,000 --> 00:51:40,120
+وماعندهاش كده يعني ما كانتش هي الإشي المهم هذا الـ
+
+526
+00:51:40,120 --> 00:51:45,820
+«Distractor» يعني هذا إشي بيضيع أما لما تقرا تشوف
+
+527
+00:51:45,820 --> 00:51:50,420
+إنه مثلا أنا المطلوب مني أشوف شو الـ «Type of
+
+528
+00:51:50,420 --> 00:51:56,080
+Inheritance» طيب الـ «Males» ولا «Females»
+
+529
+00:51:56,080 --> 00:52:00,790
+affected هاي مهم كتير، هاي واحدةإذا فيه هو أنا
+
+530
+00:52:00,790 --> 00:52:05,910
+حاطط لإيش تاني هو معطيك إنه extra nuclear DNA يعني
+
+531
+00:52:05,910 --> 00:52:09,150
+بدي يكون mitochondrial inheritance هيك بده تكون
+
+532
+00:52:09,150 --> 00:52:12,450
+النتيجة، فبروح بدور أيه ال mitochondrial؟ و هذا
+
+533
+00:52:12,450 --> 00:52:18,870
+سؤال بعتبره سهل، أنه هاي 84% يعني من كل ثمانية
+
+534
+00:52:18,870 --> 00:52:26,330
+سبعة جاوبوسة، ماشي؟ هيك بدك تمشي بالـ «هيو دكتور»؟
+
+535
+00:52:26,330 --> 00:52:26,690
+آه
+
+536
+00:52:29,890 --> 00:52:36,610
+دكتور أحمد أنا مضطر الآن في عندي كمان شغل بعد شوية
+
+537
+00:52:36,610 --> 00:52:42,170
+يوم الأربع الأربع بيكون امتحان الـ Quiz الأخير
+
+538
+00:52:42,170 --> 00:52:47,050
+شايف عليه؟ ماعليهوش علامة بس يعني عشان تدريب أو
+
+539
+00:52:47,050 --> 00:52:52,590
+بنشوف كيف بنتعامل معاه وبعد ال .. يعني مثلا نقول
+
+540
+00:52:52,590 --> 00:52:56,590
+يوم الإثنان القادم بتحبوا نقعد مرة تانية؟ إذا حد
+
+541
+00:52:56,590 --> 00:53:01,540
+عنده أسئلة زي هذا؟إذا ما بدناش نقعد على الـ Zoom
+
+542
+00:53:01,540 --> 00:53:06,220
+فيه الـ «جروب» تبع الـ Medical Genetics أتأمل أنه
+
+543
+00:53:06,220 --> 00:53:10,400
+على الـ WhatsApp بنقدر نستفيد منها يعني اللي بيحط،
+
+544
+00:53:10,400 --> 00:53:17,420
+ما حد يتواصل معايا درجاءً من طالب شخصي يعني واحد
+
+545
+00:53:17,420 --> 00:53:21,280
+دواحد اللي بيده أي سؤال من خلال الـ «جروب» الـ
+
+546
+00:53:21,280 --> 00:53:25,720
+Medical Genetics بيحط السؤال للجميع وأنا بجاوب
+
+547
+00:53:25,720 --> 00:53:27,580
+للجميع، ماشي الحال؟
+
+548
+00:53:33,180 --> 00:53:41,520
+الله يوفقكم و الله يحفظكم وإن شاء الله أكون قدرت
+
+549
+00:53:41,520 --> 00:53:47,960
+أني يعني أوصل أفكار ماشي يا كريم ويا معتز والشباب
+
+550
+00:53:47,960 --> 00:53:52,980
+والدكتورات الكل يعني يا عزيزي عفوا يا دكتور الله
+
+551
+00:53:52,980 --> 00:53:58,600
+يبارك فيك الله يحييكمأي واحد عنده أي سؤال يفضطه
+
+552
+00:53:58,600 --> 00:54:08,200
+على group المساقل للكل ويحاول يعني يكون عنده يعني
+
+553
+00:54:08,200 --> 00:54:13,160
+يودّينا شو هو السؤال بشكل واضح ممكن واحد يتكلم
+
+554
+00:54:13,160 --> 00:54:20,160
+يعني دكتور بس أكد أكد لكريم على علامةحكيت للدكتور
+
+555
+00:54:20,160 --> 00:54:25,080
+احفظه خلاص اللي موجودين كلهم كانوا يحضروا كتير
+
+556
+00:54:25,080 --> 00:54:30,520
+يعني غير علامة كريم الموجودين كلهم انهم علامة
+
+557
+00:54:30,520 --> 00:54:34,220
+لأنهم كانوا من ضمن يعني الناس الملتزمين دايما مافي
+
+558
+00:54:34,220 --> 00:54:41,060
+مشكلةما في مشكلة، الدكتور أحمد يعني أنا المشاركة
+
+559
+00:54:41,060 --> 00:54:45,060
+يعني صراحة هو صحيح، إلها دور وإلها نشاط، أه أنا
+
+560
+00:54:45,060 --> 00:54:51,400
+يعني مع أنه يعني نحط لهم bonus للي حضروا ولي حضروا
+
+561
+00:54:51,400 --> 00:54:56,260
+المرة هذه بالتالت، الله يوفقهم وإن شاء الله بيبقوا
+
+562
+00:54:56,260 --> 00:55:01,380
+على تواصلفإن شاء الله يوم الأربعة، يعني يوم
+
+563
+00:55:01,380 --> 00:55:08,160
+الثلاثة بديلك الأسئلة يا دكتور أحمد وهذه الأمر أنا
+
+564
+00:55:08,160 --> 00:55:15,420
+موافق عليه ومش إن شاء الله شو اسمه؟ هتكون الأسئلة
+
+565
+00:55:15,420 --> 00:55:19,720
+عادية ولا فيها U word يا دكتور؟ نعم هتكون الأسئلة
+
+566
+00:55:19,720 --> 00:55:24,340
+عادية ولا فيها U word؟ وإيش يعني؟ شو فيها؟ أسامة
+
+567
+00:55:24,340 --> 00:55:31,380
+بلكم مش تسأله هيكماشي شو ما يجيلك حل ماشي الله
+
+568
+00:55:31,380 --> 00:55:38,860
+يسهل الله يحييكم يلا السلام عليكم علينا علينا يلا
+
+569
+00:55:38,860 --> 00:55:39,700
+السلام عليكم
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/wEkbdETtaiE_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/wEkbdETtaiE_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..6312091c74ae55e660d35bc0de1598ffc0e29b91
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/wEkbdETtaiE_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2532, "start": 0.0, "end": 25.32, "text": "نقطة معينة الآن الصورة هذه صراحة بتعقد يعني بتخربط الواحد وبتلاقي لما تتذكر أي فصل هي موجودة", "tokens": [1863, 47432, 3660, 20449, 9957, 3660, 6024, 48506, 31767, 13063, 3660, 29538, 20328, 23557, 5016, 3660, 39894, 3615, 28543, 37495, 22653, 39894, 34740, 3555, 9566, 2423, 14407, 24401, 46599, 2655, 15040, 38436, 5296, 15042, 6055, 2655, 8848, 37983, 36632, 6156, 36520, 39896, 3714, 29245, 23328, 3660], "avg_logprob": -0.240026593208313, "compression_ratio": 1.4482758620689655, "no_speech_prob": 8.940696716308594e-07, "words": [{"start": 0.0, "end": 0.8, "word": "نقطة", "probability": 0.791748046875}, {"start": 0.8, "end": 1.46, "word": " معينة", "probability": 0.97900390625}, {"start": 1.46, "end": 3.0, "word": " الآن", "probability": 0.545684814453125}, {"start": 3.0, "end": 7.04, "word": " الصورة", "probability": 0.93603515625}, {"start": 7.04, "end": 7.74, "word": " هذه", "probability": 0.89892578125}, {"start": 7.74, "end": 9.38, "word": " صراحة", "probability": 0.78936767578125}, {"start": 9.38, "end": 10.52, "word": " بتعقد", "probability": 0.9228515625}, {"start": 10.52, "end": 11.16, "word": " يعني", "probability": 0.748291015625}, {"start": 11.16, "end": 13.26, "word": " بتخربط", "probability": 0.8294677734375}, {"start": 13.26, "end": 14.08, "word": " الواحد", "probability": 0.97705078125}, {"start": 14.08, "end": 18.18, "word": " وبتلاقي", "probability": 0.789764404296875}, {"start": 18.18, "end": 21.6, "word": " لما", "probability": 0.6834716796875}, {"start": 21.6, "end": 23.38, "word": " تتذكر", "probability": 0.8551025390625}, {"start": 23.38, "end": 23.78, "word": " أي", "probability": 0.76025390625}, {"start": 23.78, "end": 24.38, "word": " فصل", "probability": 0.96923828125}, {"start": 24.38, "end": 24.6, "word": " هي", "probability": 0.55126953125}, {"start": 24.6, "end": 25.32, "word": " موجودة", "probability": 0.9910888671875}], "temperature": 1.0}, {"id": 2, 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مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكل", "tokens": [12610, 19452, 29538, 25124, 31747, 3660, 6055, 14851, 9566, 40228, 14739, 6055, 30544, 8978, 5551, 8592, 4117, 6027, 3714, 46456, 46538, 3660, 4032, 2304, 8592, 28820, 3660, 3714, 46456, 46538, 3660, 4032, 2304, 8592, 28820, 3660, 3714, 46456, 46538, 3660, 4032, 2304, 8592, 28820, 3660, 3714, 46456, 46538, 3660, 4032, 2304, 8592, 28820, 3660, 3714, 46456, 46538, 3660, 4032, 2304, 8592, 28820, 3660, 3714, 46456, 46538, 3660, 4032, 2304, 8592, 28820, 3660, 3714, 46456, 46538, 3660, 4032, 2304, 8592, 28820, 3660, 3714, 46456, 46538, 3660, 4032, 2304, 8592, 28820, 3660, 3714, 46456, 46538, 3660, 4032, 2304, 8592, 28820, 3660, 3714, 46456, 46538, 3660, 4032, 2304, 8592, 28820, 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"probability": 0.6638997395833334}, {"start": 3616.67, "end": 3617.01, "word": " أو", "probability": 0.408935546875}, {"start": 3617.01, "end": 3617.29, "word": " هل", "probability": 0.4959716796875}, {"start": 3617.29, "end": 3617.33, "word": " يمكن", "probability": 0.782958984375}, {"start": 3617.33, "end": 3617.33, "word": " أن", "probability": 0.475830078125}, {"start": 3617.33, "end": 3617.69, "word": " يعمل", "probability": 0.7755533854166666}, {"start": 3617.69, "end": 3617.81, "word": " في", "probability": 0.34619140625}, {"start": 3617.81, "end": 3618.27, "word": " الخارج", "probability": 0.7898763020833334}, {"start": 3618.27, "end": 3619.19, "word": " في", "probability": 0.486083984375}, {"start": 3619.19, "end": 3619.51, "word": " إيجابا", "probability": 0.5428466796875}, {"start": 3619.51, "end": 3619.61, "word": " أو", "probability": 0.4931640625}, {"start": 3619.61, "end": 3619.81, "word": " بأخر", "probability": 0.5526936848958334}, {"start": 3619.81, "end": 3620.39, "word": " الدول؟", "probability": 0.5120747884114584}, {"start": 3620.39, "end": 3620.87, "word": " لذلك", "probability": 0.7122395833333334}, {"start": 3620.87, "end": 3621.11, "word": " يجب", "probability": 0.7816569010416666}, {"start": 3621.11, "end": 3621.15, "word": " أن", "probability": 0.80078125}, {"start": 3621.15, "end": 3621.45, "word": " ننظر", "probability": 0.790130615234375}, {"start": 3621.45, "end": 3621.73, "word": " إلى", "probability": 0.828125}, {"start": 3621.73, "end": 3623.13, "word": " احتاجاتنا", "probability": 0.63045654296875}, {"start": 3623.13, "end": 3623.43, "word": " وما", "probability": 0.3812255859375}, {"start": 3623.43, "end": 3623.91, "word": " يجب", "probability": 0.7333170572916666}, {"start": 3623.91, "end": 3624.03, "word": " أن", "probability": 0.68994140625}, {"start": 3624.03, "end": 3624.39, "word": " نفعله", "probability": 0.863037109375}, {"start": 3624.39, "end": 3625.05, "word": " ويجب", "probability": 0.892578125}, {"start": 3625.05, "end": 3625.11, "word": " أن", "probability": 0.89306640625}, {"start": 3625.11, "end": 3625.27, "word": " ننظر", "probability": 0.969482421875}, {"start": 3625.27, "end": 3625.41, "word": " إلى", "probability": 0.96435546875}, {"start": 3625.41, "end": 3626.37, "word": " الوصفات", "probability": 0.613818359375}, {"start": 3626.37, "end": 3626.37, "word": " المتوفرة", "probability": 0.57403564453125}, {"start": 3626.37, "end": 3627.77, "word": " والشركات", "probability": 0.5332763671875}, {"start": 3627.77, "end": 3627.95, "word": " الموجودة", "probability": 0.61572265625}, {"start": 3627.95, "end": 3627.95, "word": " في", "probability": 0.85888671875}, {"start": 3627.95, "end": 3628.47, "word": " فلسطين", "probability": 0.79947509765625}, {"start": 3628.47, "end": 3628.95, "word": " ومن", "probability": 0.463623046875}, {"start": 3628.95, "end": 3628.95, "word": " ثم", "probability": 0.863525390625}, {"start": 3628.95, "end": 3629.23, "word": " نستطيع", "probability": 0.686767578125}, {"start": 3629.23, "end": 3629.29, "word": " أن", "probability": 0.61181640625}, {"start": 3629.29, "end": 3629.71, "word": " نشارك", "probability": 0.56353759765625}, {"start": 3629.71, "end": 3630.11, "word": " ما", "probability": 0.794921875}, {"start": 3630.11, "end": 3630.37, "word": " يوجد", "probability": 0.5358072916666666}, {"start": 3630.37, "end": 3630.49, "word": " في", "probability": 0.90966796875}, {"start": 3630.49, "end": 3631.03, "word": " عقبتنا", "probability": 0.577978515625}, {"start": 3631.03, "end": 3632.21, "word": " ومشروعاتنا", "probability": 0.5329415457589286}, {"start": 3632.21, "end": 3633.43, "word": " ومشروعات", "probability": 0.7698974609375}, {"start": 3633.43, "end": 3633.73, "word": " الشركات", "probability": 0.7683919270833334}, {"start": 3633.73, "end": 3633.97, "word": " الموجودة", "probability": 0.686279296875}, {"start": 3633.97, "end": 3634.99, "word": " في", "probability": 0.71826171875}, {"start": 3634.99, "end": 3635.69, "word": " فلسطين", "probability": 0.8241455078125}, {"start": 3635.69, "end": 3636.19, "word": " ومشروعات", "probability": 0.86865234375}, {"start": 3636.19, "end": 3636.19, "word": " الشركات", "probability": 0.7467447916666666}, {"start": 3636.19, "end": 3636.19, "word": " الموجودة", "probability": 0.9688720703125}, {"start": 3636.19, "end": 3636.19, "word": " في", "probability": 0.98828125}, {"start": 3636.19, "end": 3636.19, "word": " فلسطين", "probability": 0.9955078125}, {"start": 3636.19, "end": 3636.37, "word": " ومشروعات", "probability": 0.9207356770833334}, {"start": 3636.37, "end": 3636.37, "word": " الشركات", "probability": 0.74609375}, {"start": 3636.37, "end": 3636.37, "word": " الموجودة", "probability": 0.9749755859375}, {"start": 3636.37, "end": 3636.37, "word": " في", "probability": 0.994140625}, {"start": 3636.37, "end": 3636.37, "word": " فلسطين", "probability": 0.99609375}, {"start": 3636.37, "end": 3637.11, "word": " ومشروعات", "probability": 0.9456380208333334}, {"start": 3637.11, "end": 3637.11, "word": " الشركات", "probability": 0.7979329427083334}, {"start": 3637.11, "end": 3637.11, "word": " الموجودة", "probability": 0.9810791015625}, {"start": 3637.11, "end": 3637.11, "word": " في", "probability": 0.99560546875}, {"start": 3637.11, "end": 3637.13, "word": " فلسطين", "probability": 0.9958984375}, {"start": 3637.13, "end": 3641.51, "word": " ومشروعات", "probability": 0.967529296875}, {"start": 3641.51, "end": 3642.77, "word": " الشركات", "probability": 0.8460286458333334}, {"start": 3642.77, "end": 3642.91, "word": " الموجودة", "probability": 0.984375}, {"start": 3642.91, "end": 3643.03, "word": " في", "probability": 0.99658203125}, {"start": 3643.03, "end": 3644.17, "word": " فلسط", "probability": 0.9962158203125}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 3647.5995, "duration_after_vad": 3530.307843749983}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/4KDlcB2Y79k_raw.srt b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/4KDlcB2Y79k_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..fb28e3a07aaa3d86dd7a72fbb74b60ff95183bc4
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/4KDlcB2Y79k_raw.srt
@@ -0,0 +1,3748 @@
+1
+00:00:12,600 --> 00:00:17,480
+بسم الله الرحمن الرحيم after a week of holiday
+
+2
+00:00:17,480 --> 00:00:21,560
+then we come back today to look at chapter five
+
+3
+00:00:21,560 --> 00:00:24,860
+this chapter is the longest it's the longest
+
+4
+00:00:24,860 --> 00:00:32,050
+chapter in this bookيجب أن ندرس هنا شركات و شركات
+
+5
+00:00:32,050 --> 00:00:35,210
+شركات
+
+6
+00:00:35,210 --> 00:00:41,830
+و شركات و شركات و شركات و شركات و شركات و شركات و
+
+7
+00:00:41,830 --> 00:00:41,830
+شركات و شركات و شركات و شركات و شركات و شركات و
+
+8
+00:00:41,830 --> 00:00:42,030
+شركات و شركات و شركات و شركات و شركات و شركات و
+
+9
+00:00:42,030 --> 00:00:42,030
+شركات و شركات و شركات و شركات و شركات و شركات و
+
+10
+00:00:42,030 --> 00:00:42,030
+شركات و شركات و شركات و شركات و شركات و شركات و
+
+11
+00:00:42,030 --> 00:00:42,030
+شركات و شركات و شركات و شركات و شركات و شركات و
+
+12
+00:00:42,030 --> 00:00:42,070
+شركات و شركات و شركات و شركات و شركات و شركات و
+
+13
+00:00:42,070 --> 00:00:42,150
+شركات و شركات و شركات و شركات و شركات و شركات و
+
+14
+00:00:42,150 --> 00:00:50,550
+شركات و شركات و
+
+15
+00:00:50,550 --> 00:00:57,250
+شركات
+
+16
+00:00:57,250 --> 00:01:01,930
+وهذا سيأخذ ربما 2 أو 3 أسابيع و أكتر من ذلك سيأخذ
+
+17
+00:01:01,930 --> 00:01:06,970
+3 أسابيع لإنهاء هذه القصة والقصة الأخيرة ستكون
+
+18
+00:01:06,970 --> 00:01:12,150
+الانفجار الذي يجب أن نرى بعد 3 أسابيع ، لذلك كما
+
+19
+00:01:12,150 --> 00:01:14,850
+يمكنك أن ترى أننا يجب أن نفهم في البداية ماذا يعني
+
+20
+00:01:14,850 --> 00:01:19,800
+شركةI don't know if you have been studying
+
+21
+00:01:19,800 --> 00:01:23,220
+something like this or not at least corporation is
+
+22
+00:01:23,220 --> 00:01:29,400
+one type one type of companies companies who have
+
+23
+00:01:29,400 --> 00:01:33,280
+many types one of them is corporation which is the
+
+24
+00:01:33,280 --> 00:01:37,560
+largest in size corporation is an entity كيان
+
+25
+00:01:37,560 --> 00:01:43,280
+entityولكن هذا هو أكبر في صميمة، أكبر نوع من
+
+26
+00:01:43,280 --> 00:01:46,920
+الشركات يمكننا أن ندفع شركة كما يمكنك أن ترى هنا،
+
+27
+00:01:46,920 --> 00:01:52,100
+انظر إليها يمكننا أن ندفعها كشركة حكومية، شركة
+
+28
+00:01:52,100 --> 00:01:56,600
+حكومية التي لديها شخصية حكومية مختلفة من جمهورها
+
+29
+00:01:56,600 --> 00:02:04,800
+شخصية واحدة لديها شخصية حكومية مختلفة، تخيل نفسك
+
+30
+00:02:04,800 --> 00:02:11,440
+كم طلاب لدينا، 20تخيل أنك تحب أن تكون لديك شركة و
+
+31
+00:02:11,440 --> 00:02:14,560
+تحب أن تكون لديك شركة و تحب أن تكون لديك شركة و
+
+32
+00:02:14,560 --> 00:02:15,720
+تحب أن تكون لديك شركة و تحب أن تكون لديك شركة و
+
+33
+00:02:15,720 --> 00:02:17,780
+تحب أن تكون لديك شركة و تحب أن تكون لديك شركة و
+
+34
+00:02:17,780 --> 00:02:18,860
+تحب أن تكون لديك شركة و تحب أن تكون لديك شركة و
+
+35
+00:02:18,860 --> 00:02:18,860
+تحب أن تكون لديك شركة و تحب أن تكون لديك شركة و
+
+36
+00:02:18,860 --> 00:02:19,060
+تحب أن تكون لديك شركة و تحب أن تكون لديك شركة و
+
+37
+00:02:19,060 --> 00:02:19,300
+تحب أن تكون لديك شركة و تحب أن تكون لديك شركة و
+
+38
+00:02:19,300 --> 00:02:23,760
+تحب أن تكون لديك شركة و
+
+39
+00:02:23,760 --> 00:02:32,160
+تحب
+
+40
+00:02:32,160 --> 00:02:38,240
+أن تكون لديك شرك
+
+41
+00:02:41,620 --> 00:02:48,660
+الشركات هذه تستطيع أن تعمل .. تعمل عملية مثل
+
+42
+00:02:48,660 --> 00:02:52,740
+الإنسان .. ستكون لها حقوق و مواجهة .. أنت كإنسان
+
+43
+00:02:52,740 --> 00:02:56,020
+تستطيع أن تعمل .. تستطيع أن تعمل في الشركة ..
+
+44
+00:02:56,020 --> 00:02:58,260
+تستطيع أن تعمل في الحياة العامة .. تستطيع أن تعمل
+
+45
+00:02:58,260 --> 00:03:01,180
+في العديد من العمل .. تستطيع أن تشتر .. تستطيع أن
+
+46
+00:03:01,180 --> 00:03:01,880
+تشتر .. تستطيع أن تشتر .. تستطيع أن تشتر .. تستطيع
+
+47
+00:03:01,880 --> 00:03:03,360
+أن تشتر .. تستطيع أن تشتر .. تستطيع أن تشتر ..
+
+48
+00:03:03,360 --> 00:03:03,640
+تستطيع أن تشتر .. تستطيع أن تشتر .. تستطيع أن تشتر
+
+49
+00:03:03,640 --> 00:03:10,810
+.. تستطيع أن تشتر .. تستطيع أن تشتر .. تلتعامل مع
+
+50
+00:03:10,810 --> 00:03:16,290
+الناس الآخرة نفس الشيء بالمجتمع سيكون لديه حقوق
+
+51
+00:03:16,290 --> 00:03:20,970
+وعليات في المجتمع يمكن أن يكون ممكن أن يتعامل مع
+
+52
+00:03:20,970 --> 00:03:24,890
+الناس و يتعامل مع الناس تعامل مع الناس؟ ماذا يعني
+
+53
+00:03:24,890 --> 00:03:27,870
+تعامل مع الناس؟ لقادة لقادة لذلك شركة أو مجتمع
+
+54
+00:03:27,870 --> 00:03:30,070
+يستطيع أن يتعامل مع الناس مثلك
+
+55
+00:03:33,180 --> 00:03:37,280
+وهي قد تكون قادة تستخدم مصادر في اسمها ومصادر
+
+56
+00:03:37,280 --> 00:03:42,660
+تستخدم مصادر في اسمها ومصادر تستخدم مصادر تستخدم
+
+57
+00:03:42,660 --> 00:03:44,320
+مصادر تستخدم مصادر تستخدم مصادر تستخدم مصادر
+
+58
+00:03:44,320 --> 00:03:46,900
+تستخدم مصادر تستخدم مصادر تستخدم مصادر تستخدم
+
+59
+00:03:46,900 --> 00:03:46,960
+مصادر تستخدم مصادر تستخدم مصادر تستخدم مصادر
+
+60
+00:03:46,960 --> 00:03:47,460
+تستخدم مصادر تستخدم مصادر تستخدم مصادر تستخدم
+
+61
+00:03:47,460 --> 00:03:49,000
+مصادر تستخدم مصادر تستخدم مصادر تستخدم مصادر
+
+62
+00:03:49,000 --> 00:03:56,500
+تستخدم مصادر تستخدم مصادر تستخدم مصادر
+
+63
+00:03:56,500 --> 00:03:58,840
+تستخدم
+
+64
+00:04:01,820 --> 00:04:05,120
+the corporation at the same time the corporation
+
+65
+00:04:05,120 --> 00:04:09,400
+would have the ability in to make bylaw what's a
+
+66
+00:04:09,400 --> 00:04:16,520
+bylaw what does it mean bylaw we have the law and
+
+67
+00:04:16,520 --> 00:04:20,800
+we have the bylaw what's
+
+68
+00:04:20,800 --> 00:04:27,080
+the difference between them who makes the law are
+
+69
+00:04:27,080 --> 00:04:33,130
+you okayهل لديك اتفاق اليوم؟ نعم في مدينة ماذا
+
+70
+00:04:33,130 --> 00:04:40,690
+وقت؟ اتفاق مارش اتفاق مارش اتفاق مارش اتفاق مارش
+
+71
+00:04:40,690 --> 00:04:40,770
+اتفاق مارش اتفاق مارش اتفاق مارش اتفاق مارش اتفاق
+
+72
+00:04:40,770 --> 00:04:43,570
+مارش اتفاق مارش اتفاق مارش اتفاق مارش اتفاق مارش
+
+73
+00:04:43,570 --> 00:04:46,650
+اتفاق مارش اتفاق مارش اتفاق مارش اتفاق مارش اتفاق
+
+74
+00:04:46,650 --> 00:04:50,890
+مارش اتفاق مارش اتفاق مارش اتفاق مارش اتفاق مارش
+
+75
+00:04:50,890 --> 00:04:56,450
+اتفاق مارش اتفاق مارش
+
+76
+00:04:56,450 --> 00:04:59,990
+اتفاق
+
+77
+00:04:59,990 --> 00:05:03,300
+مand this is my advice for you, just do not think
+
+78
+00:05:03,300 --> 00:05:06,000
+too much about what you had in the past, think
+
+79
+00:05:06,000 --> 00:05:08,780
+about now, think about the future, even if you
+
+80
+00:05:08,780 --> 00:05:12,560
+don't pass, even if you fail in any exam, this
+
+81
+00:05:12,560 --> 00:05:15,720
+will not be the end, you can do it again, you can
+
+82
+00:05:15,720 --> 00:05:18,460
+pass, but you have to focus on this subject to be
+
+83
+00:05:18,460 --> 00:05:21,120
+able to pass it, you don't have to think about the
+
+84
+00:05:21,120 --> 00:05:22,860
+exam you just passed a few hours ago
+
+85
+00:05:26,830 --> 00:05:30,590
+القانون .. ربما القانون في البلد ولكن بقى القانون
+
+86
+00:05:30,590 --> 00:05:34,930
+.. ربما القانون الداخلية .. القانون الداخلية لم
+
+87
+00:05:34,930 --> 00:05:39,490
+يتأثر في قانون البلد؟ نعم القانون التجاري .. لقد
+
+88
+00:05:39,490 --> 00:05:43,770
+كنا ندرس في الأسبوع الماضي القانون التجاري وقد قلت
+
+89
+00:05:43,770 --> 00:05:47,430
+قبل ذلك أننا لدينا الكثير من الجزء من القانون الآن
+
+90
+00:05:47,430 --> 00:05:51,190
+هذا القانون تم صنعه من مجلس الحكومة من مجلس
+
+91
+00:05:51,190 --> 00:05:57,210
+الحكومة لكن من قانونبيلو هو النظام الداخلي في أي
+
+92
+00:05:57,210 --> 00:06:02,970
+مؤسسة أو شركة كل شركة ستكون لها نفسها بيلو وهو
+
+93
+00:06:02,970 --> 00:06:07,950
+يسمى نظام داخلي انظر إلى هذه المدرسة الأن لديها
+
+94
+00:06:07,950 --> 00:06:09,670
+نفسها نفسها نفسها نفسها نفسها نفسها نفسها نفسها
+
+95
+00:06:09,670 --> 00:06:10,010
+نفسها نفسها نفسها نفسها نفسها نفسها نفسها نفسها
+
+96
+00:06:10,010 --> 00:06:10,010
+نفسها نفسها نفسها نفسها نفسها نفسها نفسها نفسها
+
+97
+00:06:10,010 --> 00:06:13,870
+نفسها نفسة نفسة
+
+98
+00:06:13,870 --> 00:06:18,630
+نفسة نفسة نفسة نفسة نفسة نفسة نفسة نفسة نفسة نفسة
+
+99
+00:06:18,630 --> 00:06:21,990
+نفسة
+
+100
+00:06:21,990 --> 00:06:22,770
+نفسة نفسة نفسة نفسة نفسة نفسة نفسة نفسة نفسة نفسة
+
+101
+00:06:22,770 --> 00:06:24,500
+نفسة نفسة نفسة نفسة نفسة نفسةshould not conflict
+
+102
+00:06:24,500 --> 00:06:29,040
+with the law the bylaw the internal system has to
+
+103
+00:06:29,040 --> 00:06:33,440
+be consistent with the law in the country fine
+
+104
+00:06:33,440 --> 00:06:38,660
+well it's not fine for me you have to wake up come
+
+105
+00:06:38,660 --> 00:06:41,380
+on it's not difficult it's easy but i think you're
+
+106
+00:06:41,380 --> 00:06:46,020
+still under the stress of the exam all right but
+
+107
+00:06:46,020 --> 00:06:48,820
+you should not sleep in the class you should like
+
+108
+00:06:48,820 --> 00:06:52,670
+you can sleep once you go homein the class you
+
+109
+00:06:52,670 --> 00:06:55,110
+have to be awake I mean if you once you look at
+
+110
+00:06:55,110 --> 00:06:57,110
+the marks later on your marks you will be
+
+111
+00:06:57,110 --> 00:07:00,670
+surprised they're not good they're not good
+
+112
+00:07:00,670 --> 00:07:04,210
+because you're not listening sometimes well I mean
+
+113
+00:07:04,210 --> 00:07:06,410
+not all of them some of them excellent some are
+
+114
+00:07:06,410 --> 00:07:12,030
+not listen to me and try to understand you do حنين
+
+115
+00:07:12,030 --> 00:07:14,970
+try to understand what I'm saying because you
+
+116
+00:07:14,970 --> 00:07:19,690
+still have time to study and to sleep in the class
+
+117
+00:07:19,690 --> 00:07:21,210
+you have to wake up
+
+118
+00:07:24,200 --> 00:07:29,320
+بالإضافة إلى التفريق اللذي قلنا عنه، لدينا مدرسة
+
+119
+00:07:29,320 --> 00:07:34,760
+إنقليزية اسمها Stuart Cyd وكان يدفع الشركة أو
+
+120
+00:07:34,760 --> 00:07:40,620
+الشركة إلى مجموعة من الشخصيات مثلك، مجموعة من
+
+121
+00:07:40,620 --> 00:07:47,540
+الشخصيات، أنت، 20، 10، 50، 500 شخص، مجموعة من
+
+122
+00:07:47,540 --> 00:07:53,340
+الشخصيات متجمدة في جسم واحدوهذا الجسم هو الشركة هو
+
+123
+00:07:53,340 --> 00:08:00,360
+الشركة فجميعكم مجتمعون كشخص في جسم واحد، شخص واحد،
+
+124
+00:08:00,360 --> 00:08:05,560
+شخص جديد بذلك،
+
+125
+00:08:05,560 --> 00:08:08,260
+هذا الشخص الجديد، هذا الجسم الجديد، سيكون لديه
+
+126
+00:08:08,260 --> 00:08:14,400
+المسافة، المساحة، المقدرات لتفاعل مثل أي شخص في
+
+127
+00:08:14,400 --> 00:08:18,160
+المجتمع، الشركة لديها القدرة على التفاعل في مراتب
+
+128
+00:08:18,160 --> 00:08:23,480
+مثل الشخصthey can act .. how can you imagine a
+
+129
+00:08:23,480 --> 00:08:26,380
+company can act .. what kind of activities a
+
+130
+00:08:26,380 --> 00:08:34,400
+company can do؟ legal .. like what؟ what types of
+
+131
+00:08:34,400 --> 00:08:40,400
+activities corporations can undertake؟
+
+132
+00:08:40,400 --> 00:08:43,780
+فاهمينه ولا لأ؟ أكيد؟ I doubt it
+
+133
+00:08:53,920 --> 00:08:57,020
+yes the company can sue, it can buy, it can hire,
+
+134
+00:08:57,720 --> 00:09:00,500
+it can hold assets, it can have a privilege,
+
+135
+00:09:00,640 --> 00:09:05,120
+communities, company can have many activities like
+
+136
+00:09:05,120 --> 00:09:09,140
+I can, like you can, like anyone of us, we can
+
+137
+00:09:09,140 --> 00:09:12,820
+have activities, we can buy, we can hire, you can
+
+138
+00:09:12,820 --> 00:09:18,730
+imagine yourselfبعمل تجارب تجارب تجارب تجارب تجارب
+
+139
+00:09:18,730 --> 00:09:19,430
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+140
+00:09:19,430 --> 00:09:21,110
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+141
+00:09:21,110 --> 00:09:22,190
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+142
+00:09:22,190 --> 00:09:24,010
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+143
+00:09:24,010 --> 00:09:26,210
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+144
+00:09:26,210 --> 00:09:26,770
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+145
+00:09:26,770 --> 00:09:42,210
+تجارب تجارب ت
+
+146
+00:09:43,060 --> 00:09:46,380
+فيه التزامات عقدية obligations I would have to do
+
+147
+00:09:46,380 --> 00:09:50,960
+something I would have to take an action I would
+
+148
+00:09:50,960 --> 00:09:55,580
+have the responsibility سواء being sued the same
+
+149
+00:09:55,580 --> 00:09:59,160
+thing like we had said in the previous slide
+
+150
+00:09:59,160 --> 00:10:04,120
+enjoying privilege and immunities I can enjoy
+
+151
+00:10:04,120 --> 00:10:09,280
+immunity immunity حصانة privilege MTS like a human
+
+152
+00:10:09,280 --> 00:10:12,690
+being you can have a position sometimesin which
+
+153
+00:10:12,690 --> 00:10:17,130
+you will be able to exercise privilege and
+
+154
+00:10:17,130 --> 00:10:20,860
+immunitiesشركات واحدة منها كثير من الناس كثير من
+
+155
+00:10:20,860 --> 00:10:20,920
+الناس كثير من الناس كثير من الناس كثير من الناس
+
+156
+00:10:20,920 --> 00:10:24,160
+كثير من الناس كثير من الناس كثير من الناس كثير من
+
+157
+00:10:24,160 --> 00:10:24,360
+الناس كثير من الناس كثير من الناس كثير من الناس
+
+158
+00:10:24,360 --> 00:10:28,780
+كثير من الناس كثير من الناس كثير من الناس كثير من
+
+159
+00:10:28,780 --> 00:10:35,720
+الناس كثير من الناس كثير
+
+160
+00:10:35,720 --> 00:10:39,800
+من الناس كثير من الناس
+
+161
+00:10:44,020 --> 00:10:46,560
+و يمتلكون قيمة و قيمة و قيمة و قيمة و قيمة و قيمة
+
+162
+00:10:46,560 --> 00:10:51,420
+و قيمة و قيمة و قيمة و قيمة و قيمة و قيمة و قيمة و
+
+163
+00:10:51,420 --> 00:10:56,060
+قيمة و قيمة و قيمة و قيمة و قيمة و قيمة و قيمة و
+
+164
+00:10:56,060 --> 00:10:57,120
+قيمة و قيمة و قيمة و قيمة و قيمة و قيمة و قيمة و
+
+165
+00:10:57,120 --> 00:10:57,400
+قيمة و قيمة و قيمة و قيمة و قيمة و قيمة و قيمة و
+
+166
+00:10:57,400 --> 00:10:57,400
+قيمة و قيمة و قيمة و قيمة و قيمة و قيمة و قيمة و
+
+167
+00:10:57,400 --> 00:10:57,560
+قيمة و قيمة و قيمة و قيمة و قيمة و قيمة و قيمة و
+
+168
+00:10:57,560 --> 00:11:11,200
+قيمة و قيمة و قيمة و قيمة و قيمة و قيمة و قيم
+
+169
+00:11:12,160 --> 00:11:17,200
+مثلًا نتكلم عن مجلس ميكروسوفت ورد ميرسيديس ديال
+
+170
+00:11:17,200 --> 00:11:20,240
+كمبيوتر ديال كمبيوتر ديال كمبيوتر ديال كمبيوتر
+
+171
+00:11:20,240 --> 00:11:20,480
+ديال كمبيوتر ديال كمبيوتر ديال كمبيوتر ديال
+
+172
+00:11:20,480 --> 00:11:21,520
+كمبيوتر ديال كمبيوتر ديال كمبيوتر ديال كمبيوتر
+
+173
+00:11:21,520 --> 00:11:24,760
+ديال كمبيوتر ديال كمبيوتر ديال كمبيوتر ديال
+
+174
+00:11:24,760 --> 00:11:25,340
+كمبيوتر ديال كمبيوتر ديال كمبيوتر ديال كمبيوتر
+
+175
+00:11:25,340 --> 00:11:26,940
+ديال كمبيوتر ديال كمبيوتر ديال كمبيوتر ديال
+
+176
+00:11:26,940 --> 00:11:41,720
+كمبيوتر ديال كمبيوتر ديال كمبيوتر دي
+
+177
+00:11:41,810 --> 00:11:46,970
+إذا كانت الشركة تكون لديها هذه الأشياء، أين تأتي
+
+178
+00:11:46,970 --> 00:11:52,970
+هذه الأشياء؟ هل تأتي من الشركة نفسها؟ إذا نعم، إذا
+
+179
+00:11:52,970 --> 00:11:55,550
+نعم، إذا نعم، إذا نعم، إذا نعم، إذا نعم، إذا نعم،
+
+180
+00:11:55,550 --> 00:11:56,450
+إذا نعم، إذا نعم، إذا نعم، إذا نعم، إذا نعم، إذا
+
+181
+00:11:56,450 --> 00:11:56,450
+نعم، إذا نعم، إذا نعم، إذا نعم، إذا نعم، إذا نعم،
+
+182
+00:11:56,450 --> 00:11:56,710
+إذا نعم، إذا نعم، إذا نعم، إذا نعم، إذا نعم، إذا
+
+183
+00:11:56,710 --> 00:11:56,770
+نعم، إذا نعم، إذا نعم، إذا نعم، إذا نعم، إذا نعم،
+
+184
+00:11:56,770 --> 00:12:00,810
+إذا نعم، إذا نعم، إذا نعم، إذا نعم، إذا نعم، إذا
+
+185
+00:12:00,810 --> 00:12:09,330
+نعم، إذا نعم، إذا
+
+186
+00:12:24,680 --> 00:12:28,420
+Okay look at this here, can you read it? What's
+
+187
+00:12:28,420 --> 00:12:33,170
+the name again? دالياهذا تم إكماله باعتبار تصميم
+
+188
+00:12:33,170 --> 00:12:39,450
+إدارته أو قوات التي تم إعطائها إليها في وقت
+
+189
+00:12:39,450 --> 00:12:46,030
+إبتكارها أو في أي فترة تتبع وجودها لذلك قوة
+
+190
+00:12:46,030 --> 00:12:51,810
+الشركة، هذه القوة الشركة سيتم إعطائها في وقت
+
+191
+00:12:51,810 --> 00:12:57,260
+إبتكارها عندما نجعلها موجودةفي ذلك الوقت هذه
+
+192
+00:12:57,260 --> 00:12:59,980
+الشركة و هذه الشركة ستكون لديها القوة و هذه القوة
+
+193
+00:12:59,980 --> 00:13:03,180
+ستأتي منك كمشاركات من شركات شركات شركات شركات
+
+194
+00:13:03,180 --> 00:13:04,180
+شركات شركات شركات شركات شركات شركات شركات شركات
+
+195
+00:13:04,180 --> 00:13:14,880
+شركات شركات شركات
+
+196
+00:13:15,590 --> 00:13:20,690
+على جميعنا لأننا صنعناها وقمنا بإدارتها لتعمل على
+
+197
+00:13:20,690 --> 00:13:25,510
+مجالنا وحتى بعض الأحيان هذا القوة يمكن أن تتعامل
+
+198
+00:13:25,510 --> 00:13:34,330
+عليها في مجال آخر بعد ذلك بإدارة تلك الناس تتعامل
+
+199
+00:13:34,330 --> 00:13:40,270
+على مجالها بإدارة تلك الناس تتعامل عليها بإدارة
+
+200
+00:13:40,270 --> 00:13:40,850
+تلك الناس تتعامل عليها بإدارة تلك الناس تتعامل
+
+201
+00:13:40,850 --> 00:13:40,970
+عليها بإدارة تلك الناس تتعامل عليها بإدارة تتعامل
+
+202
+00:13:40,970 --> 00:13:40,990
+عليها بإدارة تتعامل عليها بإدارة تتعامل عليها
+
+203
+00:13:40,990 --> 00:13:41,250
+بإدارة تتعامل عليها بإدارة تتعامل عليها بإدارة
+
+204
+00:13:41,250 --> 00:13:46,580
+تتعامل عليوشركتها وشركتها وشركتها وشركتها وشركتها
+
+205
+00:13:46,580 --> 00:13:53,180
+وشركتها وشركتها وشركتها
+
+206
+00:13:53,180 --> 00:13:55,980
+وشركتها وشركتها وشركتها وشركتها وشركتها وشركتها
+
+207
+00:13:55,980 --> 00:13:56,000
+وشركتها وشركتها وشركتها وشركتها وشركتها وشركتها
+
+208
+00:13:56,000 --> 00:13:56,000
+وشركتها وشركتها وشركتها وشركتها وشركتها وشركتها
+
+209
+00:13:56,000 --> 00:13:56,000
+وشركتها وشركتها وشركتها وشركتها وشركتها وشركتها
+
+210
+00:13:56,000 --> 00:13:56,080
+وشركتها وشركتها وشركتها وشركتها وشركتها وشركتها
+
+211
+00:13:56,080 --> 00:13:57,800
+وشركتها وشركتها وشركتها وشركتها وشركتها وشركتها
+
+212
+00:13:57,800 --> 00:14:10,360
+وشركت
+
+213
+00:14:11,360 --> 00:14:15,540
+الشركة وقوة هذه الشركة عندما أقول شركة في بعض
+
+214
+00:14:15,540 --> 00:14:20,000
+الأحيان هنا أنا أقصد شركة لأن الشركة هي شركة شركة
+
+215
+00:14:20,000 --> 00:14:25,500
+هي شركة ولكنها أكبر في صميمة إذا كان لدينا 10 أو
+
+216
+00:14:25,500 --> 00:14:30,320
+12 نوع من الشركات أو الشركات وشركات ثم يجب أن
+
+217
+00:14:30,320 --> 00:14:34,220
+نختار بين كل هذه النوع من الشركات بالنظر إلى
+
+218
+00:14:34,220 --> 00:14:39,760
+المساعدة ليست لديها نفس المساعدة سنقوم بالدراسة
+
+219
+00:14:39,760 --> 00:14:45,130
+هذا لاحقايجب أن ننظر إلى معنى المساعدة ولماذا بعض
+
+220
+00:14:45,130 --> 00:14:48,390
+الشركات لديها قيمة محددة و بعضها لديها قيمة غير
+
+221
+00:14:48,390 --> 00:14:52,610
+محددة حسنا،
+
+222
+00:14:52,610 --> 00:14:57,590
+هل يمكننا أن نتحرك الآن؟ كم
+
+223
+00:14:57,590 --> 00:15:02,310
+مجموعات الشركات التي لدينا؟ في الأساس، لدينا ثلاثة
+
+224
+00:15:02,310 --> 00:15:05,810
+مجموعات أو أكثر من ذلك، لدينا ثلاثة مجموعات من
+
+225
+00:15:05,810 --> 00:15:11,570
+الشركات التي نعنيها، التي نركز عليهاالذي يجب أن
+
+226
+00:15:11,570 --> 00:15:20,090
+يكون مركزنا مركزيا هو الشركة الشركة الشركة الشركة
+
+227
+00:15:20,090 --> 00:15:24,790
+الشركة الشركة الشركة الشركة الشركة الشركة الشركة
+
+228
+00:15:24,790 --> 00:15:30,670
+الشركة الشركة الشركة الشركة الشركة الشركة الشركة
+
+229
+00:15:30,670 --> 00:15:37,030
+الشركة الشركة الشركة الشركة الشركة الشركة الشركة
+
+230
+00:15:37,030 --> 00:15:37,030
+الشركة الشركة الشركة الشركة الشركة الشركة الشركة
+
+231
+00:15:37,030 --> 00:15:39,070
+الشركة الشركة الشركة الشركة الشركة الشركة الشركة
+
+232
+00:15:39,070 --> 00:15:39,310
+الشركة الشركة الشركة الشركة الشركة الشركة الشركة
+
+233
+00:15:39,310 --> 00:15:39,310
+الشركة الشركة الشركة الشركة الشركة الشركة الشركة
+
+234
+00:15:39,310 --> 00:15:39,310
+الشركة الشركة الشركة الشركة الشركة الشركة الشركة
+
+235
+00:15:39,310 --> 00:15:39,390
+الشركة الشركة الشركة الشركة الشركة الشركة الشركة
+
+236
+00:15:39,390 --> 00:15:46,410
+الشركة الشركمؤسسين يقومون باستخدام المال مؤسسين
+
+237
+00:15:46,410 --> 00:15:49,330
+يريدون أن يصنعوا المال لتصنعوا نفع يقوموا
+
+238
+00:15:49,330 --> 00:15:55,750
+باستخدامه في هذا النوع من الوقت هذا ما نسميه مؤسسة
+
+239
+00:15:55,750 --> 00:16:00,390
+لنفع مؤسسة تصنع نفع تصنع المال لأن النوع الثاني
+
+240
+00:16:00,390 --> 00:16:06,010
+ليس نفسه نفسه نفسه نفسه ليس نفسه نفسه نفسه نفسه
+
+241
+00:16:06,010 --> 00:16:06,010
+نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه
+
+242
+00:16:06,010 --> 00:16:06,670
+نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه
+
+243
+00:16:06,670 --> 00:16:08,770
+نفسه نفسه نفسه نفسه نفسه نفسه
+
+244
+00:16:10,480 --> 00:16:15,080
+شركة مساهم شركة
+
+245
+00:16:15,080 --> 00:16:19,500
+مساهم شركة
+
+246
+00:16:19,500 --> 00:16:24,860
+مساهم شركة مساهم شركة
+
+247
+00:16:24,860 --> 00:16:31,230
+مساهمثم بعمل هذا بإصلاح .. بإصلاح شركة مجموعة كهذه
+
+248
+00:16:31,230 --> 00:16:36,990
+هذه ستساعد المستخدمين
+
+249
+00:16:36,990 --> 00:16:42,270
+لتستخدم المال لأن كشخص إذا لم أستطيع أن أستخدم
+
+250
+00:16:42,270 --> 00:16:44,970
+المال لديه شركة كبيرة لأن انا أعرف أن بعض الشركات
+
+251
+00:16:46,960 --> 00:16:52,240
+هو يكلف مليار دولار ولكني كشخص ما لن أستطيع أن
+
+252
+00:16:52,240 --> 00:16:56,200
+أحصل عليه لذلك نحتاج إلى ألف أشخاص ألف أشخاص
+
+253
+00:16:56,200 --> 00:17:01,840
+انظروا كم شركات لدينا في بلستان هنا ألف شركات كم
+
+254
+00:17:01,840 --> 00:17:08,220
+منهم كم منهم شركات قليلة مثل جوال company هي شركة
+
+255
+00:17:08,220 --> 00:17:17,190
+بلستان هي شركة لكن كم شركات لديهم؟عشان ألف شركات
+
+256
+00:17:17,190 --> 00:17:22,370
+مثلا بعضها يمكن أن تكون ألف دولار أو دينار وعشان
+
+257
+00:17:22,370 --> 00:17:24,170
+أخرى يمكن أن تكون عشان ألف دولار أو دينار وعشان
+
+258
+00:17:24,170 --> 00:17:25,610
+ألف دولار أو دينار وعشان ألف دولار أو دينار وعشان
+
+259
+00:17:25,610 --> 00:17:26,670
+ألف دولار أو دينار وعشان ألف دولار أو دينار وعشان
+
+260
+00:17:26,670 --> 00:17:27,010
+ألف دولار أو دينار وعشان ألف دولار أو دينار وعشان
+
+261
+00:17:27,010 --> 00:17:27,850
+ألف دولار أو دينار وعشان ألف دولار أو دينار وعشان
+
+262
+00:17:27,850 --> 00:17:30,130
+ألف دولار أو دينار وعشان ألف دولار أو دينار وعشان
+
+263
+00:17:30,130 --> 00:17:37,770
+ألف دولار أو دينار وعشان ألف دولار أو دينار وعش
+
+264
+00:17:41,080 --> 00:17:44,820
+كلنا يمكننا أن نتعامل مع بعض نفسنا لنقوم بعمل شركة
+
+265
+00:17:44,820 --> 00:17:47,640
+لنقوم بعمل أموال لأننا لا نستطيع أن نقوم بعمل
+
+266
+00:17:47,640 --> 00:17:50,200
+أموال لإحدى نفسنا كل عدد الأموال التي لدينا لن
+
+267
+00:17:50,200 --> 00:17:53,000
+تكون كافية سوف تكون صغيرة ثم يجب أن نقوم باستخدام
+
+268
+00:17:53,000 --> 00:17:54,680
+أكتر من الأموال لنستطيع أن نقوم بعمل أكتر من
+
+269
+00:17:54,680 --> 00:17:56,920
+الأموال لنستطيع أن نقوم باستخدام أكتر من الأموال
+
+270
+00:17:56,920 --> 00:17:58,900
+لنستطيع أن نقوم باستخدام أكتر من الأموال لنستطيع
+
+271
+00:17:58,900 --> 00:18:01,520
+أن نقوم باستخدام أكتر من الأموال لنستطيع أن نقوم
+
+272
+00:18:01,520 --> 00:18:07,820
+باستخدام أك
+
+273
+00:18:07,900 --> 00:18:10,080
+it's the most common يعني أكتر انتشارة في العالم
+
+274
+00:18:10,080 --> 00:18:13,020
+it's the most common widespread of corporation
+
+275
+00:18:13,020 --> 00:18:16,720
+because we have one two three types but number one
+
+276
+00:18:16,720 --> 00:18:22,740
+is the widespread type of corporation and it's
+
+277
+00:18:22,740 --> 00:18:25,700
+called business corporation and even even
+
+278
+00:18:25,700 --> 00:18:29,400
+sometimes when we say we say business corporation
+
+279
+00:18:29,400 --> 00:18:33,700
+so even we say corporationwe mean business
+
+280
+00:18:33,700 --> 00:18:37,900
+corporation so in the future next few next time or
+
+281
+00:18:37,900 --> 00:18:40,860
+next week when I say corporation I would mean
+
+282
+00:18:40,860 --> 00:18:45,100
+business corporation the second type is municipal
+
+283
+00:18:45,100 --> 00:18:50,460
+municipal corporation can you read it cooperation
+
+284
+00:18:50,460 --> 00:18:53,220
+may also be important for local government
+
+285
+00:18:53,220 --> 00:19:00,140
+political religious and charitable purposes not
+
+286
+00:19:00,140 --> 00:19:04,180
+profitنعم، وهذا هو الطريق الثاني، إنه لا يجب أن
+
+287
+00:19:04,180 --> 00:19:07,220
+يكون لأرباح، لا يجب أن تكون لأرباح، لا يجب أن تكون
+
+288
+00:19:07,220 --> 00:19:07,900
+لأرباح، لا يجب أن تكون لأرباح، لا يجب أن تكون
+
+289
+00:19:07,900 --> 00:19:08,140
+لأرباح، لا يجب أن تكون لأرباح، لا يجب أن تكون
+
+290
+00:19:08,140 --> 00:19:09,020
+لأرباح، لا يجب أن تكون لأرباح، لا يجب أن تكون
+
+291
+00:19:09,020 --> 00:19:09,720
+لأرباح، لا يجب أن تكون لأرباح، لا يجب أن تكون
+
+292
+00:19:09,720 --> 00:19:12,220
+لأرباح، لا يجب أن تكون لأرباح، لا يجب أن تكون
+
+293
+00:19:12,220 --> 00:19:16,940
+لأرباح، لا يجب أن تكون لأرباح، لا يجب أن تكون
+
+294
+00:19:16,940 --> 00:19:20,500
+لأرباح، لا يجب أن تكون لأرباح، لا يجب أن تكون
+
+295
+00:19:20,500 --> 00:19:24,380
+لأرباح، لا يجIt can be many types, it can be
+
+296
+00:19:24,380 --> 00:19:27,840
+religion. Those here, those organizations, we call
+
+297
+00:19:27,840 --> 00:19:30,300
+them corporations, but they are not making money.
+
+298
+00:19:30,920 --> 00:19:34,080
+Those are non for profit corporations. What we
+
+299
+00:19:34,080 --> 00:19:37,240
+call them municipal. We have many of them in many
+
+300
+00:19:37,240 --> 00:19:40,120
+countries. We have in Palestine even here, we have
+
+301
+00:19:40,120 --> 00:19:46,070
+some of them هي شبه بالمؤسسات الأهلية NGOsالذين لا
+
+302
+00:19:46,070 --> 00:19:51,370
+يصنعون المال لأنفسهم أو للمجتمع أو يصنعون نفع من
+
+303
+00:19:51,370 --> 00:19:54,590
+الكثير من الناس على الرغم من أنهم يعملوا مع الناس
+
+304
+00:19:54,590 --> 00:19:58,560
+و يكونوا لديهم عملاء مختلفينوهم لديهم المال وهم
+
+305
+00:19:58,560 --> 00:20:04,600
+لديهم عقد ولكن هذا ليس لإجراء نفع لا يوجد عقد لا
+
+306
+00:20:04,600 --> 00:20:09,420
+عقد يعود للشركاء وحتى هنا لا يوجد شركاء بالمناسبة
+
+307
+00:20:09,420 --> 00:20:15,340
+هنا سنسميهم شركاء هنا سنسميهم أعضاء انا أستطيع أن
+
+308
+00:20:15,340 --> 00:20:20,780
+أكون أعضاء في واحد من هذه الشركات لكنني لن أسمي
+
+309
+00:20:20,780 --> 00:20:25,060
+نفسي شركاء لأنني لا أستثم المال هنا أنا أستثم
+
+310
+00:20:25,060 --> 00:20:28,450
+أهدافيأستطيع أن أساعد أستطيع أن أعمل أستطيع أن
+
+311
+00:20:28,450 --> 00:20:36,650
+أتعلم ثالث مرة قبل ذلك .. تفضل تفضل تفضل تفضل تفضل
+
+312
+00:20:36,650 --> 00:20:40,770
+تفضل تفضل تفضل تفضل تفضل تفضل تفضل تفضل تفضل تفضل
+
+313
+00:20:40,770 --> 00:20:40,890
+تفضل تفضل تفضل تفضل تفضل تفضل تفضل تفضل تفضل تفضل
+
+314
+00:20:40,890 --> 00:20:40,890
+تفضل تفضل تفضل تفضل تفضل تفضل تفضل تفضل تفضل تفضل
+
+315
+00:20:40,890 --> 00:20:40,890
+تفضل تفضل تفضل تفضل تفضل تفضل تفضل تفضل تفضل تفضل
+
+316
+00:20:40,890 --> 00:20:40,890
+تفضل تفضل
+
+317
+00:20:50,310 --> 00:20:56,230
+ولكن لدينا شركات تستخدم الحكومة هذه الشركات تستخدم
+
+318
+00:20:56,230 --> 00:20:58,630
+الحكومة و هذه الشركات تستخدم الحكومة و هذه الشركات
+
+319
+00:20:58,630 --> 00:20:58,850
+تستخدم الحكومة و هذه شركات تستخدم الحكومة و هذه
+
+320
+00:20:58,850 --> 00:20:58,970
+شركات تستخدم الحكومة و هذه شركات تستخدم الحكومة و
+
+321
+00:20:58,970 --> 00:20:59,470
+هذه شركات تستخدم الحكومة و هذه شركات تستخدم
+
+322
+00:20:59,470 --> 00:20:59,990
+الحكومة و هذه شركات تستخدم الحكومة و هذه شركات
+
+323
+00:20:59,990 --> 00:21:00,730
+تستخدم الحكومة و هذه شركات تستخدم الحكومة و هذه
+
+324
+00:21:00,730 --> 00:21:01,350
+شركات تستخدم الحكومة و هذه شركات تستخدم الحكومة و
+
+325
+00:21:01,350 --> 00:21:03,230
+هذه شركات تستخدم الحكومة و هذه شركات تستخدم
+
+326
+00:21:03,230 --> 00:21:09,270
+الحكومة و هذه شركات تستخدم الحكومة و
+
+327
+00:21:09,670 --> 00:21:13,150
+it's a company was working in a palestine ..
+
+328
+00:21:13,150 --> 00:21:15,910
+palestinian and this company was for the
+
+329
+00:21:15,910 --> 00:21:19,390
+government it was governmental company was work
+
+330
+00:21:19,390 --> 00:21:23,590
+for governmental program to build homes, to build
+
+331
+00:21:23,590 --> 00:21:28,650
+bridges, to manufacture things so it was .. was
+
+332
+00:21:28,650 --> 00:21:33,180
+established for the governmentلشركته الخاصة لأن في
+
+333
+00:21:33,180 --> 00:21:35,520
+بعض الأحيان تجارب مثل هذه تجارب مثل هذه شركات
+
+334
+00:21:35,520 --> 00:21:39,840
+ستفعل بعض الاختلافات التي لن يتمكن الشخص في
+
+335
+00:21:39,840 --> 00:21:44,400
+مجتمعها من القيام بها وعلى الرغم من أن لدينا بعض
+
+336
+00:21:44,400 --> 00:21:49,880
+الشركات التي لديها أكتر أموال من مصر بعض الشركات
+
+337
+00:21:49,880 --> 00:21:53,680
+لديها أكتر أموال ومجتمع أكتر من 2 او 3 أملات ولكن
+
+338
+00:21:53,680 --> 00:21:56,620
+في بعض الأحيان هنا بسبب السبب السياسي
+
+339
+00:21:59,560 --> 00:22:03,540
+ثم البلد نفسها ستكون لديها شركات مختلفة مثلما نقول
+
+340
+00:22:03,540 --> 00:22:07,640
+عن الزرق، في بعض البلدين في الغرب و حتى في
+
+341
+00:22:07,640 --> 00:22:11,760
+أفريقيا، لديهم زرق، لديهم غاز، ولكنهم لا يستطيعون
+
+342
+00:22:11,760 --> 00:22:17,860
+أن تجمعوا لإخراج الزرقfrom the earth so what they
+
+343
+00:22:17,860 --> 00:22:21,800
+do they hire .. no they have partners companies
+
+344
+00:22:21,800 --> 00:22:24,880
+from the west but now the state itself will have
+
+345
+00:22:24,880 --> 00:22:27,800
+its own company not individuals most likely the
+
+346
+00:22:27,800 --> 00:22:31,740
+state because this is public interest it concern
+
+347
+00:22:31,740 --> 00:22:35,960
+with public interest مصدا حرام and it concern with
+
+348
+00:22:35,960 --> 00:22:39,900
+return money revenue which goes for the people for
+
+349
+00:22:39,900 --> 00:22:43,460
+the societyليس للشخصيات ، لذلك يمكن أن تكون تجارب
+
+350
+00:22:43,460 --> 00:22:46,780
+مثل هذه البرنامج تعمل على شركات تتعامل بشركات
+
+351
+00:22:46,780 --> 00:22:46,820
+تتعامل مع شركات تتعامل مع شركات تتعامل مع شركات
+
+352
+00:22:46,820 --> 00:22:51,240
+تتعامل مع شركات تتعامل مع شركات تتعامل مع شركات
+
+353
+00:22:51,240 --> 00:22:51,960
+تتعامل مع شركات تتعامل مع شركات تتعامل مع شركات
+
+354
+00:22:51,960 --> 00:22:52,100
+تتعامل مع شركات تتعامل مع شركات تتعامل مع شركات
+
+355
+00:22:52,100 --> 00:22:52,100
+تتعامل مع شركات تتعامل مع شركات تتعامل مع شركات
+
+356
+00:22:52,100 --> 00:22:59,880
+تتعامل مع شركات تتعامل مع شركات تتعامل مع شركات
+
+357
+00:22:59,880 --> 00:23:09,660
+تتعامل مع شركات تتعامل مع
+
+358
+00:23:09,660 --> 00:23:13,870
+شركdominant type this is dominant the common the
+
+359
+00:23:13,870 --> 00:23:17,110
+widespread the prevalent type of corporation
+
+360
+00:23:17,110 --> 00:23:22,890
+cooperation now this has some features some
+
+361
+00:23:22,890 --> 00:23:26,930
+characteristics في مزايا في خصال these
+
+362
+00:23:26,930 --> 00:23:28,990
+characteristics here as you can see them four
+
+363
+00:23:28,990 --> 00:23:32,970
+number one two three four number one each
+
+364
+00:23:32,970 --> 00:23:36,930
+corporation would have its own legal personality
+
+365
+00:23:36,930 --> 00:23:39,550
+what does it meanwhen we say that this company
+
+366
+00:23:39,550 --> 00:23:43,450
+this corporation has its own legal personality
+
+367
+00:23:43,450 --> 00:23:48,770
+does it have name does it have name the company
+
+368
+00:23:48,770 --> 00:23:52,630
+yes why not I have name and the company can have a
+
+369
+00:23:52,630 --> 00:23:57,970
+name I can have a location can have location house
+
+370
+00:23:57,970 --> 00:24:05,130
+residence and the company can have a location what
+
+371
+00:24:05,130 --> 00:24:09,110
+do you mean by having legal personalityبالإنجليزية
+
+372
+00:24:09,110 --> 00:24:17,050
+نعم
+
+373
+00:24:17,050 --> 00:24:24,030
+نحن
+
+374
+00:24:24,030 --> 00:24:27,070
+لدينا شخصية حكومية في الواقع اللي قلت أننا لدينا
+
+375
+00:24:27,070 --> 00:24:33,670
+شركاء نعم؟ وكل شركة ستكون لديها شخصية حكومية أنا
+
+376
+00:24:33,670 --> 00:24:38,710
+أستطيع أن أكون شخصيتي خارقة منكالشركة و الشركات
+
+377
+00:24:38,710 --> 00:24:42,550
+ستكون لديها شخصية مستقلية و مختلفة و شخصية مستقلية
+
+378
+00:24:42,550 --> 00:24:44,550
+و مستقلية و شخصية مستقلية و شخصية مستقلية و شخصية
+
+379
+00:24:44,550 --> 00:24:48,450
+مستقلية و شخصية مستقلية و شخصية مستقلية و شخصية
+
+380
+00:24:48,450 --> 00:24:52,550
+مستقلية و شخصية مستقلية و شخصية مستقلية و شخصية
+
+381
+00:24:52,550 --> 00:24:52,550
+مستقلية و شخصية مستقلية و شخصية مستقلية و شخصية
+
+382
+00:24:52,550 --> 00:24:52,550
+مستقلية و شخصية مستقلية و شخصية مستقلية و شخصية
+
+383
+00:24:52,550 --> 00:25:03,710
+مستقلية و شخصية مستقلية و شخصية مستقلية و شخصية
+
+384
+00:25:03,710 --> 00:25:05,010
+مستقلية
+
+385
+00:25:07,360 --> 00:25:11,380
+هذا التطبيق تشتره كشخص مع الشركة نفسها و ليس مع
+
+386
+00:25:11,380 --> 00:25:16,620
+المشاركين لذلك يمكن الشركة أن تعمل في إسمها و كشخص
+
+387
+00:25:16,620 --> 00:25:23,060
+و كشخص و هو مثل الإنسان حسنا؟ مختلفة، لذلك
+
+388
+00:25:23,060 --> 00:25:27,220
+المساعدة المساعدة المساعدة المساعدة المساعدة
+
+389
+00:25:27,220 --> 00:25:28,480
+المساعدة المساعدة المساعدة المساعدة المساعدة
+
+390
+00:25:28,480 --> 00:25:30,260
+المساعدة المساعدة المساعدة المساعدة المساعدة
+
+391
+00:25:30,260 --> 00:25:31,160
+المساعدة المساعدة المساعدة المساعدة المساعدة
+
+392
+00:25:31,160 --> 00:25:32,000
+المساعدة المساعدة المساعدة المساعدة المساعدة
+
+393
+00:25:32,000 --> 00:25:36,630
+المساعدة المساعدة المساعدة المساعدة المسعندما ننظر
+
+394
+00:25:36,630 --> 00:25:39,750
+إلى المساعدة المحددة سأنظر إلى هذا الموضوع وانتقله
+
+395
+00:25:39,750 --> 00:25:43,750
+لأنه الآن ثانوية ثانوية هي مستخدمين يتم تحفزهم
+
+396
+00:25:43,750 --> 00:25:51,670
+ماذا يعني مستخدم مستخدم؟ مستخدمات؟ مال؟ مستخدمات
+
+397
+00:25:51,670 --> 00:25:58,650
+اقتصادية؟ في كل شركة لدينا مستخدمين و لدينا
+
+398
+00:25:58,650 --> 00:26:03,270
+مستخدمين مستخدمين مستخدمين هو الشخص اللي يمتلك
+
+399
+00:26:03,270 --> 00:26:08,410
+المستخدمينو .. و .. و .. و .. و .. و .. و .. و ..
+
+400
+00:26:08,410 --> 00:26:08,730
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+401
+00:26:08,730 --> 00:26:11,310
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+402
+00:26:11,310 --> 00:26:13,050
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+403
+00:26:13,050 --> 00:26:13,110
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+404
+00:26:13,110 --> 00:26:13,590
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+405
+00:26:13,590 --> 00:26:13,590
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+406
+00:26:13,590 --> 00:26:14,950
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+407
+00:26:14,950 --> 00:26:14,950
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+408
+00:26:14,950 --> 00:26:16,490
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+409
+00:26:16,490 --> 00:26:19,050
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+410
+00:26:19,050 --> 00:26:22,870
+و .. و ..
+
+411
+00:26:22,870 --> 00:26:25,550
+و .. و ..
+
+412
+00:26:34,450 --> 00:26:39,550
+وهذا لن يؤثر على مصطلح الشركة مصطلح الشركة سيكون
+
+413
+00:26:39,550 --> 00:26:42,990
+كما هو لن يؤثر على الشركة شركة هي شركة الشركة هي
+
+414
+00:26:42,990 --> 00:26:46,230
+شركة تستطيع أن تكون موجودة لوقت طويل حتى إذا كنت
+
+415
+00:26:46,230 --> 00:26:49,730
+أغادر حتى إذا شخص ممكن أن يموت شخص يستطيع أن يسحب
+
+416
+00:26:49,730 --> 00:26:53,070
+شركته و يستطيع أن يشتري أكتر الشركة يستطيع أن تكون
+
+417
+00:26:53,070 --> 00:26:56,810
+موجودة مثلا إذا كان علي أن أغادر 5000 شركة في اسمي
+
+418
+00:26:56,810 --> 00:27:03,420
+و أريد أن أسحبهاأتي ده يعني .. I can sell them ..
+
+419
+00:27:03,420 --> 00:27:06,560
+I can leave .. but the shares can stay ولا لأ؟ yes
+
+420
+00:27:06,560 --> 00:27:09,200
+the shares can stay in the company and the company
+
+421
+00:27:09,200 --> 00:27:11,680
+will not be affected if we say that this company
+
+422
+00:27:11,680 --> 00:27:15,420
+has a million .. million shares .. million .. and
+
+423
+00:27:15,420 --> 00:27:18,200
+we have to leave fifty shareholders .. only fifty
+
+424
+00:27:18,200 --> 00:27:21,400
+shareholders .. now those fifty shareholders can
+
+425
+00:27:21,400 --> 00:27:21,900
+be twenty
+
+426
+00:27:24,740 --> 00:27:27,860
+عشان تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا
+
+427
+00:27:27,860 --> 00:27:34,600
+تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا
+
+428
+00:27:34,600 --> 00:27:34,700
+تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا
+
+429
+00:27:34,700 --> 00:27:35,720
+تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا
+
+430
+00:27:35,720 --> 00:27:35,980
+تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا
+
+431
+00:27:35,980 --> 00:27:36,000
+تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا
+
+432
+00:27:36,000 --> 00:27:45,080
+تقريبا تقريبا تقريبا ت
+
+433
+00:27:52,020 --> 00:27:57,400
+perpetual succession from
+
+434
+00:27:57,400 --> 00:28:07,160
+here
+
+435
+00:28:07,160 --> 00:28:13,020
+how
+
+436
+00:28:13,020 --> 00:28:16,540
+long
+
+437
+00:28:16,540 --> 00:28:19,990
+somebody can live a human being how longthe life
+
+438
+00:28:19,990 --> 00:28:22,770
+expectation life expectation of a human being can
+
+439
+00:28:22,770 --> 00:28:27,490
+be seventy eighty something like this years how
+
+440
+00:28:27,490 --> 00:28:29,730
+long a company can live what's the life
+
+441
+00:28:29,730 --> 00:28:34,590
+expectation of a company it doesn't depend on the
+
+442
+00:28:34,590 --> 00:28:38,370
+life of one of the shareholders it's not like they
+
+443
+00:28:38,370 --> 00:28:44,890
+start a partnership it's more like when theyالشركة
+
+444
+00:28:44,890 --> 00:28:48,610
+لا تعتمد على عمر محدد الشركة تستطيع أن تعيش خمسة
+
+445
+00:28:48,610 --> 00:28:53,370
+سنة تستطيع أن تعيش خمس ألف سنة وهذا ما نسميه تعاقب
+
+446
+00:28:53,370 --> 00:28:59,170
+دائم تعاقب دائم تعاقب دائم تعاقب دائم تعاقب دائم
+
+447
+00:28:59,170 --> 00:28:59,890
+تعاقب دائم تعاقب دائم تعاقب دائم تعاقب دائم تعاقب
+
+448
+00:28:59,890 --> 00:28:59,930
+دائم تعاقب دائم تعاقب دائم تعاقب دائم تعاقب دائم
+
+449
+00:28:59,930 --> 00:29:03,330
+تعاقب دائم تعاقب دائم تعاقب دائم تعاقب دائم تعاقب
+
+450
+00:29:03,330 --> 00:29:13,560
+دائم تعاقب دائم تعاقب ديمكنه ان يترخى ويمكنه أن
+
+451
+00:29:13,560 --> 00:29:17,380
+يسحب شركاته الشركات يمكنها أن تكون موجودة ل2 أو
+
+452
+00:29:17,380 --> 00:29:21,960
+300 سنة بشخص مخلوق هذه الشركات ويمكنه أن يترخى
+
+453
+00:29:21,960 --> 00:29:24,840
+ويمكنه أن يسحب شركاتها الشركات لذا فالشركات لن
+
+454
+00:29:24,840 --> 00:29:28,560
+تكون مؤثرة على الشركات على الإطلاق بموت الشركة
+
+455
+00:29:28,560 --> 00:29:35,260
+اللازمة رقم أربعة هو المساعدة المحددة واحد من
+
+456
+00:29:35,260 --> 00:29:40,740
+المواصفات المفروضةلشركة بشكل عام ومجتمع بشكل محدد
+
+457
+00:29:40,740 --> 00:29:45,280
+هي قيمة محددة وهذا هو الموضوع اللي يجب أن نركز
+
+458
+00:29:45,280 --> 00:29:48,700
+عليه قيمة محددة يمكن أن تكون قيمة محددة أو محددة
+
+459
+00:29:48,700 --> 00:29:54,520
+غير محددة قيمة محددة يعني مسؤولية قانونية قومية
+
+460
+00:29:54,520 --> 00:29:59,820
+ماذا أقدر أن أفعل؟ ماذا هي عملياتي؟ هذا هو قيمة
+
+461
+00:29:59,820 --> 00:30:02,680
+محددة هذه القيمة ممكن أن تكون قيمة محددة أحياناً
+
+462
+00:30:02,680 --> 00:30:06,080
+ممكن أن تكون قيمة غير محددة هل تعرفت هذا الموضوع؟
+
+463
+00:30:09,540 --> 00:30:19,020
+خلاص محدود و لا محدود؟ محدود و لا
+
+464
+00:30:19,020 --> 00:30:23,320
+محدود؟ محدود
+
+465
+00:30:23,320 --> 00:30:34,480
+و لا محدود؟ محدود و لا محدود؟ محدود و لا محدود؟
+
+466
+00:30:34,480 --> 00:30:38,080
+محدود و لا محدود؟ محدود و لا محدود؟ محدود و لا
+
+467
+00:30:38,080 --> 00:30:38,080
+محدود؟ محدود و لا محدود؟ محدود و لا محدود؟ محدود و
+
+468
+00:30:38,080 --> 00:30:38,080
+لا محدود؟ محدود و لا محدود؟ محدود و لا محدود؟
+
+469
+00:30:38,080 --> 00:30:38,100
+محدود و لا محدود؟ محدود و لا محدود؟ محدود و لا
+
+470
+00:30:38,100 --> 00:30:38,120
+محدود؟ محدود و لا محدود؟ محدود و لا محدود؟ محدود و
+
+471
+00:30:38,120 --> 00:30:40,610
+لا محدود؟ محدود و لا محدود؟سيكون لديه وصفة مليئة
+
+472
+00:30:40,610 --> 00:30:45,170
+ولكن الشركات ستكون لديها وصفة مليئة ولكن الشركات
+
+473
+00:30:45,170 --> 00:30:47,590
+ستكون لديها وصفة مليئة ولكن الشركات ستكون لديها
+
+474
+00:30:47,590 --> 00:30:49,950
+وصفة مليئة ولكن الشركات ستكون لديها وصفة مليئة
+
+475
+00:30:49,950 --> 00:30:50,650
+ولكن الشركات ستكون لديها وصفة مليئة ولكن الشركات
+
+476
+00:30:50,650 --> 00:30:51,830
+ستكون لديها وصفة مليئة ولكن الشركات ستكون لديها
+
+477
+00:30:51,830 --> 00:30:52,870
+وصفة مليئة ولكن الشركات ستكون لديها وصفة مليئة
+
+478
+00:30:52,870 --> 00:30:56,010
+ولكن الشركات ستكون لديها وصفة مليئة ولكن الشركات
+
+479
+00:30:56,010 --> 00:31:00,890
+ستكون لديها وصفة مليئة ولكن الشركات ستكون لديها
+
+480
+00:31:00,890 --> 00:31:02,790
+وصفة مليئة ول
+
+481
+00:31:08,110 --> 00:31:11,630
+هذه المالة هي 10 ألف ريال ، لذلك اقسم أنه لن أكون
+
+482
+00:31:11,630 --> 00:31:21,460
+مسؤول عن المالشركة العادية البسيطة شركة
+
+483
+00:31:21,460 --> 00:31:36,400
+العادية
+
+484
+00:31:36,400 --> 00:31:38,800
+البسيطة شركة العادية البسيطة شركة العادية البسيطة
+
+485
+00:31:38,800 --> 00:31:41,580
+شركة العادية البسيطة شركة العادية البسيطة شركة
+
+486
+00:31:41,580 --> 00:31:44,670
+العادية البسيطةأنا أستطيع أن أخسر المال اللي قمت
+
+487
+00:31:44,670 --> 00:31:48,230
+به و انا أستطيع أن أخسر حتى المال اللي قمت بإنقاذه
+
+488
+00:31:48,230 --> 00:31:52,810
+في حقيبتي أستطيع أن أستخدم كل مالي حقيبتي بعض
+
+489
+00:31:52,810 --> 00:31:56,670
+الناس يستطيعون أن يخسر حتى منزلهم هذا يجب أن نلقي
+
+490
+00:31:56,670 --> 00:32:00,130
+نظرة عليه عندما ندرس الانتجار الانتجار في الحلقة
+
+491
+00:32:00,130 --> 00:32:05,350
+التالية ان شاء الله فإن قيمة محددة يعني أن الشركاء
+
+492
+00:32:05,350 --> 00:32:12,560
+سيكونون بأمنستيسيكون حماسا من أي حركة كانت قامت
+
+493
+00:32:12,560 --> 00:32:17,760
+بالتعامل معها انا لا اهتم اذا كانت الشركة فاتت او
+
+494
+00:32:17,760 --> 00:32:25,900
+اذا كانت الشركة قامت بخطأ ضد المستخدم او اذا كانت
+
+495
+00:32:25,900 --> 00:32:27,780
+الشركة فاتت او اذا كانت الشركة فاتت او اذا كانت
+
+496
+00:32:27,780 --> 00:32:29,240
+الشركة فاتت او اذا كانت الشركة فاتت او اذا كانت
+
+497
+00:32:29,240 --> 00:32:32,760
+الشركة فاتت او اذا كانت الشركة فاتت
+
+498
+00:32:36,600 --> 00:32:41,040
+we have a law it's corporation law how can we make
+
+499
+00:32:41,040 --> 00:32:44,780
+a company how can we make a corporation today if i
+
+500
+00:32:44,780 --> 00:32:46,840
+would like to make a corporation i would have to
+
+501
+00:32:46,840 --> 00:32:50,060
+study the law i would have to look exactly at the
+
+502
+00:32:50,060 --> 00:32:53,580
+law how can we establish a corporation we have
+
+503
+00:32:53,580 --> 00:32:56,260
+something called corporate law we call it
+
+504
+00:32:56,260 --> 00:33:00,640
+sometimes corporation law or company law we still
+
+505
+00:33:00,640 --> 00:33:03,300
+have next two slides we have to look at company
+
+506
+00:33:03,300 --> 00:33:08,880
+lawقانون الشركات هي قانون الشركات نفسها لا يوجد
+
+507
+00:33:08,880 --> 00:33:16,920
+فرق كبير بينهم لأن كل شركة هي شركة كل شركة هي شركة
+
+508
+00:33:16,920 --> 00:33:19,980
+الأن كيف يمكننا أن ندفع كيف يمكننا أن ندفع القانون
+
+509
+00:33:19,980 --> 00:33:25,980
+الشركات قانون الشركات قانون
+
+510
+00:33:25,980 --> 00:33:30,200
+الشركات قانون الشركات قانون الشركات قانون الشركات
+
+511
+00:33:30,200 --> 00:33:33,180
+قانون الشركات قانون الشركات قانون الشركات قانون
+
+512
+00:33:33,180 --> 00:33:39,740
+الشركات قانون الشركاتOkay two points this law as
+
+513
+00:33:39,740 --> 00:33:43,220
+you can see corporation law would govern first of
+
+514
+00:33:43,220 --> 00:33:46,820
+all would establish the law establishing separate
+
+515
+00:33:46,820 --> 00:33:50,800
+legal identity separate legal entity law itself
+
+516
+00:33:50,800 --> 00:33:53,720
+how can I make a company I would have to look at
+
+517
+00:33:53,720 --> 00:33:57,740
+the law what documents we need how much money do
+
+518
+00:33:57,740 --> 00:34:00,420
+we need the capital how many shareholders do we
+
+519
+00:34:00,420 --> 00:34:07,570
+need locationشكل شركة الشركة كل شيء سيجلس في شيء
+
+520
+00:34:07,570 --> 00:34:15,610
+يسمى كتابة كمباني كتابة
+
+521
+00:34:15,610 --> 00:34:20,050
+الشركات و
+
+522
+00:34:20,050 --> 00:34:23,710
+في نفس الوقت حتى نفس الكتابة نفس الكتابة ستعطينا
+
+523
+00:34:23,710 --> 00:34:28,610
+فكرة كيف نمشي كيف نسيطر كيف نسيطر كيف نحكم كيف
+
+524
+00:34:28,610 --> 00:34:28,910
+نحكم
+
+525
+00:34:32,180 --> 00:34:36,560
+والقانون نفسها ستركز على أشياء أساسية، تخبر الناس
+
+526
+00:34:36,560 --> 00:34:43,660
+كيف تبنوا شركة، كيف تبنيها، وكيف تدفعها، كيف
+
+527
+00:34:43,660 --> 00:34:48,360
+تحكمها، كيف تحكم شركتين مثلها في الولايات المتحدة،
+
+528
+00:34:48,360 --> 00:34:52,660
+القانون الشركي هو مجموعة من القانون الشركية،
+
+529
+00:34:52,660 --> 00:34:59,560
+مجموعة من ماذا؟ مجموعة فرعSo cooperation law in
+
+530
+00:34:59,560 --> 00:35:02,780
+the UK is a subset of companies of him فرع منه جزء
+
+531
+00:35:02,780 --> 00:35:10,260
+منه is that clear؟ now even corporations is
+
+532
+00:35:10,260 --> 00:35:13,600
+distinguished cooperation in general is
+
+533
+00:35:13,600 --> 00:35:17,280
+distinguished from other business entities they
+
+534
+00:35:17,280 --> 00:35:19,340
+are not the same like others like for example here
+
+535
+00:35:19,340 --> 00:35:27,240
+look at the wider spectrum مساحة يعني واسعةمجموعات
+
+536
+00:35:27,240 --> 00:35:31,900
+أكتر من المجموعات الاجتماعية ليسوا نفسها مثل
+
+537
+00:35:31,900 --> 00:35:37,640
+الشركات مثلًا مثل الpartnership، يجب أن ندرس هذه
+
+538
+00:35:37,640 --> 00:35:42,600
+النقطة، هذه المجموعات، partnership، لدينا عدد صغير
+
+539
+00:35:42,600 --> 00:35:48,080
+من الناس، و لديهم قيمة صغيرة من المال المستخدم، و
+
+540
+00:35:48,080 --> 00:35:51,700
+ليس لديهم قيامة محددة، لدينا حتى هنا مجتمعات غير
+
+541
+00:35:51,700 --> 00:36:00,630
+مجتمعيةهنا بدون أسهم شركات غير مساهمة or sole
+
+542
+00:36:00,630 --> 00:36:04,170
+proprietorship شخص واحد one person who invest
+
+543
+00:36:04,170 --> 00:36:08,010
+money in his own name we have to look at all these
+
+544
+00:36:08,010 --> 00:36:11,330
+entities and others later on but you have to keep
+
+545
+00:36:11,330 --> 00:36:13,790
+in mind that corporation is not the same it's not
+
+546
+00:36:13,790 --> 00:36:19,430
+like them well
+
+547
+00:36:19,430 --> 00:36:21,830
+we have to go back now to companies title of
+
+548
+00:36:21,830 --> 00:36:27,990
+companyماذا يعني شركة؟ ماذا يعني شركة؟ نحن نفهم
+
+549
+00:36:27,990 --> 00:36:34,230
+بشكل محدد التعاون كمجموعة
+
+550
+00:36:34,230 --> 00:36:40,310
+من الناس مجموعة من الناس مجموعة من الناس مجموعة من
+
+551
+00:36:40,310 --> 00:36:40,990
+الناس مجموعة من الناس مجموعة من الناس مجموعة من
+
+552
+00:36:40,990 --> 00:36:40,990
+الناس مجموعة من الناس مجموعة من الناس مجموعة من
+
+553
+00:36:40,990 --> 00:36:41,630
+الناس مجموعة من الناس مجموعة من الناس مجموعة من
+
+554
+00:36:41,630 --> 00:36:43,110
+الناس مجموعة من الناس مجموعة من الناس مجموعة من
+
+555
+00:36:43,110 --> 00:36:45,330
+الناس مجموعة من الناس مجموعة من الناس مجموعة من
+
+556
+00:36:45,330 --> 00:36:50,740
+الناس مجموعة من الناس مجموعة من الناسwhat company؟
+
+557
+00:36:50,740 --> 00:36:53,700
+is it the same؟ does it have a different meaning
+
+558
+00:36:53,700 --> 00:36:57,980
+company؟ is it the same؟ it has a broad meaning
+
+559
+00:36:57,980 --> 00:37:01,500
+broad meaning yes company has a broad meaning it's
+
+560
+00:37:01,500 --> 00:37:03,780
+not like corporation because company can include
+
+561
+00:37:03,780 --> 00:37:09,300
+corporation and can include other entitiesإذا كنا
+
+562
+00:37:09,300 --> 00:37:12,660
+نحب أن ننظر إلى شركة تنظر إلى كلمة company في
+
+563
+00:37:12,660 --> 00:37:17,380
+اللغة الشركة لن تكون لديها معنى مستقل لن تكون
+
+564
+00:37:17,380 --> 00:37:21,840
+لديها معنى .. انظر ليس لديها معنى مستقل و صحيح لأن
+
+565
+00:37:21,840 --> 00:37:28,340
+شركة كلمة يمكن تحمي أكتر من واحد معنى شركة يمكن
+
+566
+00:37:28,340 --> 00:37:31,840
+يعني شركة يمكن يعني شركة مشاركة يمكن يعني شركة
+
+567
+00:37:31,840 --> 00:37:35,320
+مشاركة يمكن يعني شركة مشاركةit means it means
+
+568
+00:37:35,320 --> 00:37:39,580
+limited liability company it can mean limited
+
+569
+00:37:39,580 --> 00:37:43,200
+company it has many meanings it has many types so
+
+570
+00:37:43,200 --> 00:37:48,020
+we will not be easily able to define company but
+
+571
+00:37:48,020 --> 00:37:52,280
+we can say it can be specifically here form of
+
+572
+00:37:52,280 --> 00:37:57,380
+entity it's an entity created under the laws for
+
+573
+00:37:57,380 --> 00:37:59,940
+relevant jurisdiction it's an entity in general
+
+574
+00:37:59,940 --> 00:38:04,840
+entityولكن هذه الشركة تستطيع أن تكون في أشكال
+
+575
+00:38:04,840 --> 00:38:07,640
+مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة
+
+576
+00:38:07,640 --> 00:38:09,200
+ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة
+
+577
+00:38:09,200 --> 00:38:11,200
+مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة
+
+578
+00:38:11,200 --> 00:38:11,340
+ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة
+
+579
+00:38:11,340 --> 00:38:11,380
+مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة
+
+580
+00:38:11,380 --> 00:38:13,600
+ومشكلة مختلفة ومشكلة مختلفة ومشكلة مختلفة ومشكلة
+
+581
+00:38:13,600 --> 00:38:22,040
+مختلفة ومشكلة مختلفة ومشكل
+
+582
+00:38:25,380 --> 00:38:32,300
+وهي لديها شخصية قانونية مختلفة من شركاتها وهي فقط
+
+583
+00:38:32,300 --> 00:38:37,840
+في المجتمع لتقديم عملية شركات مجتمعية؟ هذه
+
+584
+00:38:37,840 --> 00:38:45,060
+الدفينيشن كما ترى هي أكتر من الدفينيشن للمجتمع
+
+585
+00:38:45,060 --> 00:38:50,900
+الآن نستطيع أن نقول جوريستك شخص قانوني أو شخص
+
+586
+00:38:50,900 --> 00:38:55,070
+قانونيjuristic person legal entity fictitious
+
+587
+00:38:55,070 --> 00:38:58,350
+person the way you like it any definition would be
+
+588
+00:38:58,350 --> 00:39:01,870
+fine for me which has separate legal identity
+
+589
+00:39:01,870 --> 00:39:06,010
+separate legal identity from its shareholding
+
+590
+00:39:06,010 --> 00:39:10,150
+member up to this moment up to this point exactly
+
+591
+00:39:10,150 --> 00:39:14,130
+the same what we had for corporation company and
+
+592
+00:39:14,130 --> 00:39:16,030
+corporation up to this moment up to this point
+
+593
+00:39:16,030 --> 00:39:17,810
+here in the same here separate legal
+
+594
+00:39:24,220 --> 00:39:29,580
+وهي تستخدمها لتحقيق شركات تستخدمها لتحقيق شركات
+
+595
+00:39:29,580 --> 00:39:30,400
+تستخدمها لتحقيق شركات تستخدمها لتحقيق شركات
+
+596
+00:39:30,400 --> 00:39:35,720
+تستخدمها لتحقيق شركات تستخدمها لتحقيق شركات
+
+597
+00:39:35,720 --> 00:39:41,160
+تستخدمها لتحقيق شركات تستخدمها لتحقيق شركات
+
+598
+00:39:42,920 --> 00:39:48,300
+هنا في باليستان لدينا نوعين من الشركات المهمة هي
+
+599
+00:39:48,300 --> 00:39:55,920
+شركات مالية وشركات لا مالية وشركات
+
+600
+00:39:55,920 --> 00:40:00,020
+لا مالية وشركات لا مالية وشركات لا مالية وشركات لا
+
+601
+00:40:00,020 --> 00:40:00,120
+مالية وشركات لا مالية وشركات لا مالية وشركات لا
+
+602
+00:40:00,120 --> 00:40:00,800
+مالية وشركات لا مالية وشركات لا مالية وشركات لا
+
+603
+00:40:00,800 --> 00:40:00,800
+مالية وشركات لا مالية وشركات لا مالية وشركات لا
+
+604
+00:40:00,800 --> 00:40:00,800
+مالية وشركات لا مالية وشركات لا مالية وشركات لا
+
+605
+00:40:00,800 --> 00:40:00,800
+مالية وشركات لا مالية وشركات لا مالية وشركات لا
+
+606
+00:40:00,800 --> 00:40:03,940
+مالية وشركات لا مالية وشركات لا مالية وشركات لا
+
+607
+00:40:03,940 --> 00:40:07,350
+مالية وشركات لا مالية وشركاتالشركات إلى مجموعات
+
+608
+00:40:07,350 --> 00:40:11,870
+ممكن تكون في بعض الأحيان مجتمع و غير مجتمع يمكن أن
+
+609
+00:40:11,870 --> 00:40:16,670
+يكون مستخدم و لا مستخدم واحدة من المفروضات للشركات
+
+610
+00:40:16,670 --> 00:40:23,550
+هي المساعدة المحددة و شخصية مختلفة هذه هي اتفاقين
+
+611
+00:40:23,550 --> 00:40:29,170
+اتفاقين اتفاقينفي الواقع الكثير من الناس اليوم
+
+612
+00:40:29,170 --> 00:40:33,870
+يذهبون لشركة مثل هذه لأنه أسهل لهم ان يكون أفضل من
+
+613
+00:40:33,870 --> 00:40:37,630
+الحصول على مpartnership على سبيل المثال في شركات
+
+614
+00:40:37,630 --> 00:40:41,930
+مثل هذه يمكنك أن تكون لديك عياب محددة لأني لن أكون
+
+615
+00:40:41,930 --> 00:40:46,150
+قادر على التفكير بشكل كبير عن العمل وكيف يمكنني أن
+
+616
+00:40:46,150 --> 00:40:49,870
+أستثمر؟ كيف يمكنني أن أحصل على الprofit؟ كم يمكنني
+
+617
+00:40:49,870 --> 00:40:54,170
+أن أخسر؟ سوف أفكر فقط عن القيم الصغيرة أو القيم
+
+618
+00:40:54,170 --> 00:40:59,630
+التي استثمرت فيهابإمكانك أن تنام بسلام دون أن تفكر
+
+619
+00:40:59,630 --> 00:41:03,290
+حتى في مستقبل هذه الشركة لأن حتى إذا كانت هذه
+
+620
+00:41:03,290 --> 00:41:07,310
+الشركة تخسر المال أو تخسر كل شيء و كانت مغلقة أو
+
+621
+00:41:07,310 --> 00:41:10,890
+مغلقة انا سأكون قادر على الاستثمار في شيء آخر أو
+
+622
+00:41:10,890 --> 00:41:13,570
+ربما سأكون قادر على الحصول على بعض المال مني انا
+
+623
+00:41:13,570 --> 00:41:18,910
+أستثمر في شركة مختلفة ولكن قيامة محددة هذه فرصة
+
+624
+00:41:18,910 --> 00:41:25,460
+لشركات واحدة وفي نفس الوقت شخصية مختلفةالشركات
+
+625
+00:41:25,460 --> 00:41:31,860
+مختلفة، هذا يعني أن الشركات لن تكون مرتبطة، لن
+
+626
+00:41:31,860 --> 00:41:36,180
+تكون مسؤولة عن أي حركة، كل الأعمال التي تفعلها
+
+627
+00:41:36,180 --> 00:41:40,760
+الشركة، الشركة ستكون مسؤولة عن هذا، أنا أستثمر
+
+628
+00:41:40,760 --> 00:41:46,170
+المال فقط للمال، للربح، و الشركة لديها إسم خاصand
+
+629
+00:41:46,170 --> 00:41:49,850
+under that name the company can lose can win can
+
+630
+00:41:49,850 --> 00:41:53,310
+stay can die can survive this is not my
+
+631
+00:41:53,310 --> 00:41:58,030
+responsibility and this is why companies become
+
+632
+00:41:58,030 --> 00:42:02,910
+popular famous in which most people in the world
+
+633
+00:42:02,910 --> 00:42:07,290
+involved in business forming companies many people
+
+634
+00:42:07,290 --> 00:42:13,750
+find it easy for them to establish companiesو هذا
+
+635
+00:42:13,750 --> 00:42:17,990
+أسهل بكثير من أن أكون شخصيا في إسمي لأن إذا كنت
+
+636
+00:42:17,990 --> 00:42:21,530
+أقوم بالاستثمار في إسمي في إسمي كشخص عملي و إذا
+
+637
+00:42:21,530 --> 00:42:24,790
+كنت أفقد، فسأفقد كل شيء و إذا كان لدي مسؤولية،
+
+638
+00:42:24,790 --> 00:42:28,750
+فسأكون لدي مسؤولية شخصية، مسؤولية، فاليوم حتى كما
+
+639
+00:42:28,750 --> 00:42:33,430
+ترين هنا، أن بعض الناس، ما يفعلونه، ما يفعلونه،
+
+640
+00:42:33,430 --> 00:42:37,430
+يقومون بالاستثمار في المال، يقومون بالاستثمار في
+
+641
+00:42:37,430 --> 00:42:41,220
+المال، و لن يكونوا لديهم المسؤوليةهو لن يكون لديه
+
+642
+00:42:41,220 --> 00:42:47,180
+فرصة وحتى بالإضافة لهذا .. بالإضافة لهذا هذه
+
+643
+00:42:47,180 --> 00:42:54,220
+الشركات لديها استخدامات إضافية استخدامات إضافية في
+
+644
+00:42:54,220 --> 00:42:57,700
+الواقع الناس يستطيعون الذهاب إلى نوع مثل هذا و هذه
+
+645
+00:42:57,700 --> 00:43:02,000
+الاستخدامات ستكون مثل هنا رقم 1 .. هل أستطيع أن
+
+646
+00:43:02,000 --> 00:43:02,420
+تقرأها؟
+
+647
+00:43:13,940 --> 00:43:17,120
+partnership and individuals how much money can
+
+648
+00:43:17,120 --> 00:43:21,880
+invest here not much as a partnership or as
+
+649
+00:43:21,880 --> 00:43:25,440
+individual we can make money we can invest but
+
+650
+00:43:25,440 --> 00:43:31,540
+will not be asأكبر من المال الذي يمكننا أن نستخدمه
+
+651
+00:43:31,540 --> 00:43:35,040
+في الشركات العامة الشركات التي يمكنها أن يكون لها
+
+652
+00:43:35,040 --> 00:43:37,900
+الكثير من الناس يمكنها أن يكون لها آلاف شركات
+
+653
+00:43:37,900 --> 00:43:41,300
+مستخدمين يستخدمون مالهم ويمكنك أن تصنع شركة أكبر
+
+654
+00:43:41,300 --> 00:43:48,260
+في أضافة إلى هذا حتى هنا الشركات
+
+655
+00:43:48,260 --> 00:43:50,000
+يمكنها أن تكون مستخدمين
+
+656
+00:43:54,210 --> 00:43:57,430
+الشركات لن تكون لديها مقاومة أكتر من المال، لن
+
+657
+00:43:57,430 --> 00:44:01,130
+تكون لديها مقاومة أكتر من المال، الشركات لن تكون
+
+658
+00:44:01,130 --> 00:44:01,530
+لديها مقاومة أكتر من المال، لن تكون لديها مقاومة
+
+659
+00:44:01,530 --> 00:44:01,530
+أكتر من المال، لن تكون لديها مقاومة أكتر من المال،
+
+660
+00:44:01,530 --> 00:44:03,190
+لن تكون لديها مقاومة أكتر من المال، لن تكون لديها
+
+661
+00:44:03,190 --> 00:44:03,930
+مقاومة أكتر من المال، لن تكون لديها مقاومة أكتر من
+
+662
+00:44:03,930 --> 00:44:05,270
+المال، لن تكون لديها مقاومة أكتر من المال، لن تكون
+
+663
+00:44:05,270 --> 00:44:08,670
+لديها مقاومة أكتر من المال، لن تكون لديها مقاومة
+
+664
+00:44:08,670 --> 00:44:11,760
+أكتر منولكن بعد 50 سنة تستطيع أن تحصل على 50 مليون
+
+665
+00:44:11,760 --> 00:44:17,000
+باونز أو 500 مليون باونز فمن الممكن أن تكون هذه
+
+666
+00:44:17,000 --> 00:44:22,280
+الشركات تستطيعون تفتح عملتها وتفتح عملتها وتفتح
+
+667
+00:44:22,280 --> 00:44:25,820
+عملتها وتفتح عملتها تفتح عملتها تفتح عملتها تفتح
+
+668
+00:44:25,820 --> 00:44:25,980
+عملتها تفتح عملتها تفتح عملتها تفتح عملتها تفتح
+
+669
+00:44:25,980 --> 00:44:26,440
+عملتها تفتح عملتها تفتح عملتها تفتح عملتها تفتح
+
+670
+00:44:26,440 --> 00:44:28,280
+عملتها تفتح عملتها تفتح عملتها تفتح عملتها تفتح
+
+671
+00:44:28,280 --> 00:44:34,900
+عملتها تفتح عملتها تفتح عملتها تفتح عملت
+
+672
+00:44:35,790 --> 00:44:38,930
+initially formed as a sole proprietorship can
+
+673
+00:44:38,930 --> 00:44:42,130
+eventually grow as publicly listed company some
+
+674
+00:44:42,130 --> 00:44:44,650
+people can start some people can start in their
+
+675
+00:44:44,650 --> 00:44:49,310
+own name as individual sole proprietorship one
+
+676
+00:44:49,310 --> 00:44:53,590
+person شخص واحد and then later on after many years
+
+677
+00:44:53,590 --> 00:44:58,050
+then he can he can switch you know what switchمن
+
+678
+00:44:58,050 --> 00:45:01,630
+شركة مالكة الوحيدة إلى شركة و يمكن أن يكون هناك
+
+679
+00:45:01,630 --> 00:45:05,470
+الكثير من الناس معه أو معها يستخدمون المال في
+
+680
+00:45:05,470 --> 00:45:09,590
+شركات مثل هذه ولكن حتى و حتى و حتى و حتى و حتى و
+
+681
+00:45:09,590 --> 00:45:09,970
+حتى و حتى و حتى و حتى و حتى و حتى و حتى و حتى و
+
+682
+00:45:09,970 --> 00:45:11,370
+حتى و حتى و حتى و حتى و حتى و حتى و حتى و حتى و
+
+683
+00:45:11,370 --> 00:45:13,330
+حتى و حتى و حتى و حتى و حتى و حتى و حتى و حتى و
+
+684
+00:45:13,330 --> 00:45:13,410
+حتى و حتى و حتى و حتى و حتى و حتى و حتى و حتى و
+
+685
+00:45:13,410 --> 00:45:13,430
+حتى و حتى و حتى و حتى و حتى و حتى و حتى و حتى و
+
+686
+00:45:13,430 --> 00:45:13,450
+حتى و حتى و حتى و حتى و حتى و حتى و حتى و حتى و
+
+687
+00:45:13,450 --> 00:45:21,530
+حتى و حتى و حتى و
+
+688
+00:45:21,530 --> 00:45:25,800
+حتى ولن نستخدم المال أكتر إلا إذا قمنا بتغييره
+
+689
+00:45:25,800 --> 00:45:28,360
+تماما مثلا إذا قمنا بإغلاق البرنامج و نفتح شركة
+
+690
+00:45:28,360 --> 00:45:33,800
+جديدة مثلا هنا في الpartnership لدينا عدد أكتر من
+
+691
+00:45:33,800 --> 00:45:37,860
+المشاركين الشركات لديها عدد أكتر من الشركات؟ في
+
+692
+00:45:37,860 --> 00:45:41,540
+العام العام لا في الشركات لا لدينا عدد أكتر من
+
+693
+00:45:41,540 --> 00:45:44,480
+الشركات نستطيع أن نكون مليونين شركات أكتر من
+
+694
+00:45:44,480 --> 00:45:44,840
+الشركات نستطيع أن نكون مليونين شركات أكتر من
+
+695
+00:45:44,840 --> 00:45:47,020
+الشركات نستطيع أن نكون مليونين شركات أكتر من
+
+696
+00:45:47,020 --> 00:45:48,520
+الشركات نستطيع أن نكون مليونين شركات أكتر من
+
+697
+00:45:48,520 --> 00:45:53,050
+الشركات نستطيع أن نكون مليونين شركات50 partners لا
+
+698
+00:45:53,050 --> 00:45:58,330
+اكثر لان لدينا عدد كبير من الشركات و بعدها نستطيع
+
+699
+00:45:58,330 --> 00:46:01,370
+ان نكون لدينا عدد كبير من المال اللي نستطيع ان
+
+700
+00:46:01,370 --> 00:46:04,890
+نستخدمه لاننا لن نستطيع ان نستطيع ان نستخدم هذا
+
+701
+00:46:04,890 --> 00:46:07,290
+الشركة لاننا لن نستطيع ان نستطيع ان نستخدم اكتر من
+
+702
+00:46:07,290 --> 00:46:13,190
+المال في شركة مثلها لذلك هذا ليس مثل شركة اكتر من
+
+703
+00:46:13,190 --> 00:46:14,450
+المال في شركة اكتر من المال في شركة اكتر من المال
+
+704
+00:46:14,450 --> 00:46:15,250
+في شركة اكتر من المال في شركة اكتر من المال في
+
+705
+00:46:15,250 --> 00:46:15,870
+شركة اكتر من المال في شركة اكتر من المال في شركة
+
+706
+00:46:15,870 --> 00:46:21,450
+اكتر من المال في شركة اكتر من المال في شركة اكتoh
+
+707
+00:46:21,450 --> 00:46:25,730
+no it's not company's law we did we did just a few
+
+708
+00:46:25,730 --> 00:46:28,710
+minutes ago i was talking about corporation law
+
+709
+00:46:28,710 --> 00:46:32,090
+now we have company's law is it the same or is it
+
+710
+00:46:32,090 --> 00:46:34,170
+not? what do you think?
+
+711
+00:46:40,470 --> 00:46:43,430
+company's law is the field of law concerning a
+
+712
+00:46:43,430 --> 00:46:48,730
+business and other organizationsأو مؤسسات ومؤسسات
+
+713
+00:46:48,730 --> 00:46:54,690
+أخرى التي تستمر في بعض الأعمال الاقتصادية أو
+
+714
+00:46:54,690 --> 00:47:00,610
+المساعدة حسنًا، انظر إلى الانتقال هنا تركيب شركة
+
+715
+00:47:00,610 --> 00:47:06,810
+مثل هذه تركيب شركة تركيب شركة تركيب شركة تركيب
+
+716
+00:47:06,810 --> 00:47:14,770
+شركة تركيب شركة تركيب شركة تركيب شركة تركيب شركة
+
+717
+00:47:14,770 --> 00:47:14,870
+تركيب شركة تركيب شركة تركيب شركة تركيب شركة تركيب
+
+718
+00:47:14,870 --> 00:47:15,650
+شركة تركيب شركة تركيب شركة تركيب شركة تركيب شركة
+
+719
+00:47:15,650 --> 00:47:15,650
+تركيب شركة تركيب شركة تركيب شركة تركيب شركة تركيب
+
+720
+00:47:15,650 --> 00:47:20,030
+شركة تركيب شركةتو أشخاص أساسية واحدة منهم هو الناس
+
+721
+00:47:20,030 --> 00:47:21,450
+المالية والثانية منهم الناس المالية والثانية منهم
+
+722
+00:47:21,450 --> 00:47:22,370
+الناس المالية والثانية منهم الناس المالية والثانية
+
+723
+00:47:22,370 --> 00:47:23,670
+منهم الناس المالية والثانية منهم الناس المالية
+
+724
+00:47:23,670 --> 00:47:25,030
+والثانية منهم الناس المالية والثانية منهم الناس
+
+725
+00:47:25,030 --> 00:47:26,750
+المالية والثانية منهم الناس المالية والثانية منهم
+
+726
+00:47:26,750 --> 00:47:26,770
+الناس المالية والثانية منهم الناس المالية والثانية
+
+727
+00:47:26,770 --> 00:47:26,770
+منهم الناس المالية والثانية منهم الناس المالية
+
+728
+00:47:26,770 --> 00:47:28,950
+والثانية منهم الناس المالية والثانية منهم الناس
+
+729
+00:47:28,950 --> 00:47:34,790
+المالية والثانية منهم الناس المالية والثانية منهم
+
+730
+00:47:34,790 --> 00:47:43,060
+الناس المالية والثانية منهم الناس المالشركات، حتى
+
+731
+00:47:43,060 --> 00:47:47,840
+في بلستان، كما قلت في البداية، لدينا اثنين نوعين
+
+732
+00:47:47,840 --> 00:47:51,960
+من الشركات المهمة، الانبعاثات و الانبعاثات
+
+733
+00:47:51,960 --> 00:47:55,400
+الانبعاثات و لدينا مئات مئات من الشركات الانبعاثات
+
+734
+00:47:55,400 --> 00:47:59,920
+في بلستين، و اعتقد ان في قطر غازيا، لدينا اكتر من
+
+735
+00:47:59,920 --> 00:48:07,010
+800 شركات انبعاثات800 non profit companies هم هما
+
+736
+00:48:07,010 --> 00:48:10,770
+يسموهم جمعيات الأهلية اسمها فيهم ال NGOs هم هم هم
+
+737
+00:48:10,770 --> 00:48:13,390
+هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم
+
+738
+00:48:13,390 --> 00:48:14,030
+هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم
+
+739
+00:48:14,030 --> 00:48:14,910
+هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم
+
+740
+00:48:14,910 --> 00:48:14,910
+هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم
+
+741
+00:48:14,910 --> 00:48:14,910
+هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم
+
+742
+00:48:14,910 --> 00:48:14,910
+هم هم هم هم هم هم هم هم هم هم
+
+743
+00:48:28,150 --> 00:48:29,530
+كمبيوتر او شركة او شركة او شركة او شركة او شركة او
+
+744
+00:48:29,530 --> 00:48:30,430
+شركة او شركة او شركة او شركة او شركة او شركة او
+
+745
+00:48:30,430 --> 00:48:34,050
+شركة او شركة او شركة او شركة او شركة او شركة او
+
+746
+00:48:34,050 --> 00:48:34,370
+شركة او شركة او شركة او شركة او شركة او شركة او
+
+747
+00:48:34,370 --> 00:48:34,370
+شركة او شركة او شركة او شركة او شركة او شركة او
+
+748
+00:48:34,370 --> 00:48:39,470
+شركة او شركة او شركة او شركة او شركة او
+
+749
+00:48:39,470 --> 00:48:48,870
+شركة او شركة او شركة او
+
+750
+00:48:48,870 --> 00:48:50,830
+شركة
+
+751
+00:48:51,980 --> 00:48:56,100
+شركات صغيرة ستكون صغيرة مثلًا شركات صغيرة بقدرة
+
+752
+00:48:56,100 --> 00:48:59,280
+صغيرة من المال لا يجب علينا أن نرسمهم على محافظة
+
+753
+00:48:59,280 --> 00:49:04,700
+السوق ماذا يعني عندما نقول انها محافظة السوق ماذا
+
+754
+00:49:04,700 --> 00:49:10,240
+يعني أن نرسم شركة على محافظة السوق الشركات يمكن أن
+
+755
+00:49:10,240 --> 00:49:13,260
+تكون مجتمع ويمكن أن تكون مجتمع مجتمع مجتمع مجتمع
+
+756
+00:49:13,260 --> 00:49:15,880
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+757
+00:49:15,880 --> 00:49:17,580
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+758
+00:49:17,580 --> 00:49:18,600
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+759
+00:49:18,600 --> 00:49:20,600
+مجتمع مج
+
+760
+00:49:22,190 --> 00:49:25,030
+Did you hear about the stock exchange؟ سوق البورصة
+
+761
+00:49:25,030 --> 00:49:29,470
+سمعته فيه؟ How many companies we have in Palestine
+
+762
+00:49:29,470 --> 00:49:33,530
+are listed on the stock exchange market؟ ازاي؟
+
+763
+00:49:33,530 --> 00:49:39,590
+اغضيه؟ I don't think so I think less than this I
+
+764
+00:49:39,590 --> 00:49:45,310
+think last year somebody was saying No
+
+765
+00:49:45,310 --> 00:49:47,970
+no I'm talking about the listed on the stock
+
+766
+00:49:47,970 --> 00:49:54,470
+exchangeممكن أن يكون هناك 37 شركات فقط موجودة على
+
+767
+00:49:54,470 --> 00:49:58,490
+الشركة الدوسية دوس هي أكتر منها في كمية من المال
+
+768
+00:49:58,490 --> 00:50:04,770
+التي يمكنها الناس أن تشتريها في أي شركة دوس دوس
+
+769
+00:50:04,770 --> 00:50:07,590
+فتفتح الباب لأي شخص يستطيع أن يتعامل معها و يستطيع
+
+770
+00:50:07,590 --> 00:50:08,230
+أن يتعامل معها و يستطيع أن يتعامل معها و يستطيع أن
+
+771
+00:50:08,230 --> 00:50:09,670
+يتعامل معها و يستطيع أن يتعامل معها و يستطيع أن
+
+772
+00:50:09,670 --> 00:50:10,670
+يتعامل معها و يستطيع أن يتعامل معها و يستطيع أن
+
+773
+00:50:10,670 --> 00:50:12,210
+يتعامل معها و يستطيع أن يتعامل معها و يستطيع أن
+
+774
+00:50:12,210 --> 00:50:18,630
+يتعامل معها و يستطيع أن يتعامل معها و يستطيع أن ي
+
+775
+00:50:18,730 --> 00:50:20,870
+والشركات الخاصة هي أكتر من الممكن أن تكون لديها
+
+776
+00:50:20,870 --> 00:50:26,510
+قطعة صغيرة من المال مستخدمة مع قليل من الناس و
+
+777
+00:50:26,510 --> 00:50:29,630
+أكتر من الممكن أن تكون من نفس العائلة من نفس
+
+778
+00:50:29,630 --> 00:50:32,770
+العائلة من نفس الأصدقاء مثلا الناس يعرفون بعضهم
+
+779
+00:50:32,770 --> 00:50:37,050
+البعض مثلا لديك أصدقاء 5 أو 6 شخص و أنت تثق ببعضك
+
+780
+00:50:37,050 --> 00:50:40,690
+و أنت تستخدم المال مع بعضك، هذا مخصص ولكن الأول
+
+781
+00:50:40,690 --> 00:50:45,130
+هنا أكتر في صفر هؤلاء مباشرةand the second one
+
+782
+00:50:45,130 --> 00:50:49,190
+private we will look at this later on anyway the
+
+783
+00:50:49,190 --> 00:50:52,450
+most prominent kind the most famous kind of
+
+784
+00:50:52,450 --> 00:50:58,390
+company is called corporation the famous the most
+
+785
+00:50:58,390 --> 00:51:03,650
+prominent اكتر شي مشهور in company it's called
+
+786
+00:51:03,650 --> 00:51:05,010
+corporation
+
+787
+00:51:06,930 --> 00:51:10,910
+نحن لدينا بعض الميزات لشركات مثل هذه التي تدفع
+
+788
+00:51:10,910 --> 00:51:16,150
+ميزات تدفع ميزات تدفع ميزات تدفع ميزات تدفع ميزات
+
+789
+00:51:16,150 --> 00:51:16,950
+تدفع ميزات تدفع ميزات تدفع ميزات تدفع ميزات تدفع
+
+790
+00:51:16,950 --> 00:51:18,150
+ميزات تدفع ميزات تدفع ميزات تدفع ميزات تدفع ميزات
+
+791
+00:51:18,150 --> 00:51:20,010
+تدفع ميزات تدفع ميزات تدفع ميزات تدفع ميزات تدفع
+
+792
+00:51:20,010 --> 00:51:21,890
+ميزات تدفع ميزات تدفع ميزات تدفع ميزات تدفع ميزات
+
+793
+00:51:21,890 --> 00:51:22,910
+تدفع ميزات تدفع ميزات تدفع
+
+794
+00:51:36,510 --> 00:51:41,610
+Who can take the lead؟ What do we have؟ How can we
+
+795
+00:51:41,610 --> 00:51:46,130
+select؟ Voting system. Election. We have election.
+
+796
+00:51:46,270 --> 00:51:50,030
+انتخابات ولا لأ؟ We have voting system. We can
+
+797
+00:51:50,030 --> 00:51:54,870
+appoint directors who control the company by the
+
+798
+00:51:54,870 --> 00:51:58,850
+voting system. Who gets the highest votes can
+
+799
+00:51:58,850 --> 00:52:03,020
+lead.يستطيع أن يأخذ الرئيسية ويستطيع أن يسيطر على
+
+800
+00:52:03,020 --> 00:52:06,580
+تلك الشركات وهذه هي الطريقة الأفضل لأن هؤلاء الناس
+
+801
+00:52:06,580 --> 00:52:12,760
+مثقفين وليس مواطنين ولكن مختارين حتى انهم مختارين
+
+802
+00:52:12,760 --> 00:52:16,400
+من مجتمعهم وانت متأكد من كيف يمكنك أن تكون رئيس؟
+
+803
+00:52:16,400 --> 00:52:19,440
+وانت متأكد من كيف يمكنك أن تكون رئيس؟ وانت متأكد
+
+804
+00:52:19,440 --> 00:52:19,640
+من كيف يمكنك أن تكون رئيس؟ وانت متأكد من كيف يمكنك
+
+805
+00:52:19,640 --> 00:52:19,640
+أن تكون رئيس؟ وانت متأكد من كيف يمكنك أن تكون
+
+806
+00:52:19,640 --> 00:52:23,580
+رئيس؟ وانت متأكد من كيف يمكنك أن تكون رئيس؟ وانت
+
+807
+00:52:23,580 --> 00:52:29,120
+متأكد من كيف يمكنك أن50 شيرز هل سأكون قادر على
+
+808
+00:52:29,120 --> 00:52:32,780
+التخلص من نفسي؟ لا أعتقد ذلك كل شركة ستكون ..
+
+809
+00:52:32,780 --> 00:52:37,280
+ستكون لديها نظام التخلص محدد يخبرك بالضبط كيف
+
+810
+00:52:37,280 --> 00:52:40,820
+يمكنك التخلص من نفسك مثلا قد يكون أحيانًا أقل ..
+
+811
+00:52:40,820 --> 00:52:46,100
+أقل المال اللي قضيته 50 ألف باون أو 20 ألف باون أو
+
+812
+00:52:46,100 --> 00:52:48,880
+مليون باون لتكون قادر على التخلص من نفسك؟ يتعامل
+
+813
+00:52:48,880 --> 00:52:51,600
+أعتقد في كل شركة في .. في قانونها
+
+814
+00:52:54,510 --> 00:52:58,870
+النظام الداخلي سيفرح بالضبط كم المال نحتاجه لكي
+
+815
+00:52:58,870 --> 00:53:01,910
+نكون قادرين على الاختيار نفسنا وماذا تعتقد؟ في
+
+816
+00:53:01,910 --> 00:53:06,030
+نظام الاختيار، كم مجموعات نحن لدينا؟ يمكنني أن
+
+817
+00:53:06,030 --> 00:53:08,370
+يكون لديك مجموعات أكتر منك أو ربما يمكنك أن تكون
+
+818
+00:53:08,370 --> 00:53:11,610
+لديك مجموعات أكتر مني، فهذا يعتمد على المال اللي
+
+819
+00:53:11,610 --> 00:53:14,830
+قمنا به إذا قمت بإستخدام مليون دولار وقمت بإستخدام
+
+820
+00:53:14,830 --> 00:53:18,870
+50 ألف دولار، هل سأكون لدي نفس المجموعات مثله؟
+
+821
+00:53:18,870 --> 00:53:25,700
+بالطبع ليسطبعا ليس كذلك، لدينا مجموعات، وكل مقدم
+
+822
+00:53:25,700 --> 00:53:30,940
+من المال يسمى كمجموعة، وكل 10 ألف رمز يمكن أن يكون
+
+823
+00:53:30,940 --> 00:53:37,180
+الانتجار، ربما، كما قلت، هذا يمكن ان يكون مصمم في
+
+824
+00:53:37,180 --> 00:53:41,760
+الانتجار منذ البداية، عندما نصبح الشركة
+
+825
+00:53:47,200 --> 00:53:49,320
+أفضل أفضل أفضل أفضل أفضل أفضل أفضل أفضل أفضل أفضل
+
+826
+00:53:49,320 --> 00:53:49,600
+أفضل أفضل أفضل أفضل أفضل أفضل أفضل أفضل أفضل أفضل
+
+827
+00:53:49,600 --> 00:53:50,880
+أفضل أفضل أفضل أفضل أفضل أفضل أفضل أفضل أفضل أفضل
+
+828
+00:53:50,880 --> 00:53:54,300
+أفضل أفضل أفضل أفضل أفضل أفضل أفضل أفضل أفضل أفضل
+
+829
+00:53:54,300 --> 00:53:54,300
+أفضل أفضل أفضل أفضل أفضل أفضل أفضل أفضل أفضل أفضل
+
+830
+00:53:54,300 --> 00:53:54,600
+أفضل أفضل أفضل أفضل أفضل أفضل
+
+831
+00:54:15,710 --> 00:54:19,670
+بعض منهم لديه قيادة محددة و البعض لديه قيادة غير
+
+832
+00:54:19,670 --> 00:54:24,570
+محددة ننظر إلى هذا واحد على واحد عندما نصل إلى هذا
+
+833
+00:54:24,570 --> 00:54:31,670
+النقطة و حتى اذا كانت التشاركات ممكن تقلل القيادة،
+
+834
+00:54:31,670 --> 00:54:38,290
+فالتشاركات قد تقلل قيادتهم لخسارة الشركةبقية القوة
+
+835
+00:54:38,290 --> 00:54:42,110
+لديك الاختيارات تستطيع أن تذهب للسيستم اللي يسمح
+
+836
+00:54:42,110 --> 00:54:46,330
+لك ان تاخذ اختيارات كهذه و حتى .. حتى .. هل يمكنك
+
+837
+00:54:46,330 --> 00:54:49,550
+أن تصدق ان بعض المكان مثل الـ sole proprietorship
+
+838
+00:54:49,550 --> 00:54:53,510
+و sole traders مالك الوحيد شخص تاجر يستطيع أن يقلل
+
+839
+00:54:53,510 --> 00:55:00,250
+قيمته أو قيمته؟ هذا ليس فرصة عامة ولكن بصراحة هذا
+
+840
+00:55:00,250 --> 00:55:04,910
+يحدث بعض المكان مثل دستي يقول ان إذا كنت sole
+
+841
+00:55:04,910 --> 00:55:08,520
+traderأنا أريد أن أقل قيمتي، يمكنك أن تقل قيمتك،
+
+842
+00:55:08,520 --> 00:55:10,600
+يمكنك أن تقل قيمتك، يمكنك أن تقل قيمتك، يمكنك أن
+
+843
+00:55:10,600 --> 00:55:10,840
+تقل قيمتك، يمكنك أن تقل قيمتك، يمكنك أن تقل قيمتك،
+
+844
+00:55:10,840 --> 00:55:11,880
+يمكنك أن تقل قيمتك، يمكنك أن تقل قيمتك، يمكنك أن
+
+845
+00:55:11,880 --> 00:55:13,920
+تقل قيمتك، يمكنك أن تقل قيمتك، يمكنك أن تقل قيمتك،
+
+846
+00:55:13,920 --> 00:55:16,980
+يمكنك أن تقل قيمتك، يمكنك أن تقل قيمتك، يمكنك أن
+
+847
+00:55:16,980 --> 00:55:21,300
+تقل قيمتك، يمكنك أن تقل قيمتك، يمكنك أن تقل قيمتك،
+
+848
+00:55:21,300 --> 00:55:27,440
+يمكنك أن تقل قيمتك، يمكنك أن تقلcompany in ..
+
+849
+00:55:27,440 --> 00:55:31,360
+company معنوها بالعربي مجموعة أصلا company say my
+
+850
+00:55:31,360 --> 00:55:33,460
+company somebody in my company يعني الشريكة أو
+
+851
+00:55:33,460 --> 00:55:36,740
+زميلة و كده but even company here despite the fact
+
+852
+00:55:36,740 --> 00:55:40,020
+it means that meaning collection of people or many
+
+853
+00:55:40,020 --> 00:55:44,240
+people even though sometimes some places they have
+
+854
+00:55:44,240 --> 00:55:49,300
+they have option in which one person can can what?
+
+855
+00:55:50,770 --> 00:55:52,650
+و يقومون باستخدام نفسهم و يقومون باستخدام نفسهم و
+
+856
+00:55:52,650 --> 00:55:53,790
+يقومون باستخدام نفسهم و يقومون باستخدام نفسهم و
+
+857
+00:55:53,790 --> 00:55:54,630
+يقومون باستخدام نفسهم و يقومون باستخدام نفسهم و
+
+858
+00:55:54,630 --> 00:55:57,470
+يقومون باستخدام نفسهم و يقومون باستخدام نفسهم و
+
+859
+00:55:57,470 --> 00:55:59,910
+يقومون باستخدام نفسهم و يقومون باستخدام نفسهم و
+
+860
+00:55:59,910 --> 00:56:00,410
+يقومون باستخدام نفسهم و يقومون باستخدام نفسهم و
+
+861
+00:56:00,410 --> 00:56:02,610
+يقومون باستخدام نفسهم و يقومون باستخدام نفسهم و
+
+862
+00:56:02,610 --> 00:56:11,090
+يقومون باستخدام
+
+863
+00:56:11,090 --> 00:56:13,430
+نفسهم و يقومون باستخدام نفسهم
+
+864
+00:56:21,180 --> 00:56:24,340
+corporation sorry partnership only one partnership
+
+865
+00:56:24,340 --> 00:56:27,920
+in the united states we have four types we'll look
+
+866
+00:56:27,920 --> 00:56:31,860
+at them one by one once we get to that point i
+
+867
+00:56:31,860 --> 00:56:33,800
+think this is the last slide take it for today
+
+868
+00:56:33,800 --> 00:56:38,860
+last slide the last slide it's easy this is an
+
+869
+00:56:38,860 --> 00:56:42,520
+easy slide in the united states united states
+
+870
+00:56:42,520 --> 00:56:48,340
+companies low in the united states we have 51 or
+
+871
+00:56:48,340 --> 00:56:59,340
+52 states51 51 states okay 52 51 states 52 states
+
+872
+00:56:59,340 --> 00:57:02,180
+whatever in united states each state by the way
+
+873
+00:57:02,180 --> 00:57:07,100
+each state has its own law each state we will not
+
+874
+00:57:07,100 --> 00:57:10,760
+we cannot see that one commercial law no companies
+
+875
+00:57:10,760 --> 00:57:14,800
+law in all states i mean it's not at the federal
+
+876
+00:57:14,800 --> 00:57:20,180
+level at a state levelالقانون العامة لن تكون
+
+877
+00:57:20,180 --> 00:57:26,400
+مجموعة في مستوى الوزيرات، لن تكون مجموعة في مستوى
+
+878
+00:57:26,400 --> 00:57:27,440
+الوزيرات، لن تكون مجموعة في مستوى الوزيرات، لن
+
+879
+00:57:27,440 --> 00:57:27,540
+تكون مجموعة في مستوى الوزيرات، لن تكون مجموعة في
+
+880
+00:57:27,540 --> 00:57:28,800
+مستوى الوزيرات، لن تكون مجموعة في مستوى الوزيرات،
+
+881
+00:57:28,800 --> 00:57:30,000
+لن تكون مجموعة في مستوى الوزيرات، لن تكون مجموعة
+
+882
+00:57:30,000 --> 00:57:32,100
+في مستوى الوزيرات، لن تكون مجموعة في مستوى
+
+883
+00:57:32,100 --> 00:57:38,280
+الوزيرات، لن تكون مجموعة في مستوى الوزيرات، لن
+
+884
+00:57:38,280 --> 00:57:39,830
+تكون مجموعة في مستوى الوزCorporate law governs
+
+885
+00:57:39,830 --> 00:57:43,170
+that corporation's internal authority even if the
+
+886
+00:57:43,170 --> 00:57:46,210
+corporation's operations take place outside of
+
+887
+00:57:46,210 --> 00:57:49,650
+that state okay perfect corporate law will govern
+
+888
+00:57:49,650 --> 00:57:53,250
+corporation's internal authority even though if
+
+889
+00:57:53,250 --> 00:57:56,950
+this company if this corporation function outside
+
+890
+00:57:56,950 --> 00:57:59,550
+the state if this company was established in
+
+891
+00:57:59,550 --> 00:58:04,780
+californiaوهو يعمل بعض الأعمال في نيويورك وهذه
+
+892
+00:58:04,780 --> 00:58:07,980
+الشركة ستبقى بالطبع في نفس حكومتها الداخلية حتى
+
+893
+00:58:07,980 --> 00:58:11,700
+هنا نفس الحكومة الداخلية ستبقى بالطبع في نفس
+
+894
+00:58:11,700 --> 00:58:13,960
+حكومتها داخلية حكومتها داخلية حكومتها حكومتها
+
+895
+00:58:13,960 --> 00:58:15,320
+حكومتها حكومتها حكومتها حكومتها حكومتها حكومتها
+
+896
+00:58:15,320 --> 00:58:15,640
+حكومتها حكومتها حكومتها حكومتها حكومتها حكومتها
+
+897
+00:58:15,640 --> 00:58:15,880
+حكومتها حكومتها حكومتها حكومتها حكومتها حكومتها
+
+898
+00:58:15,880 --> 00:58:15,880
+حكومتها حكومتها حكومتها حكومتها حكومتا حكومتا
+
+899
+00:58:15,880 --> 00:58:27,960
+حكومتا حك
+
+900
+00:58:29,370 --> 00:58:36,490
+هو يجب أن يتأكد في الانتصار على الشكل والقياس يجب
+
+901
+00:58:36,490 --> 00:58:41,330
+أن يتأكد في أفعالهto be able to function in
+
+902
+00:58:41,330 --> 00:58:44,250
+accordance with the new state with the new estate
+
+903
+00:58:44,250 --> 00:58:47,930
+so because corporate law can be different various
+
+904
+00:58:47,930 --> 00:58:51,090
+states and not the same from one state to another
+
+905
+00:58:51,090 --> 00:58:53,570
+we have to look at the significance and the
+
+906
+00:58:53,570 --> 00:58:56,230
+advantage we'll look at this later on once we look
+
+907
+00:58:56,230 --> 00:58:59,290
+again at corporations in which we see that some
+
+908
+00:58:59,290 --> 00:59:05,710
+states they have tax free tax freeبعض الولايات
+
+909
+00:59:05,710 --> 00:59:09,090
+لديها تجارب عالية و البعض لديهم تجارب عالية فالناس
+
+910
+00:59:09,090 --> 00:59:11,390
+يستطيعوا أن يبحثوا عن أفضل تجارب و يختاروا أفضل
+
+911
+00:59:11,390 --> 00:59:17,650
+تجارب مثلا في إنجلات أو بريطانيا أو أمريكافي بعض
+
+912
+00:59:17,650 --> 00:59:21,990
+الأسطورة إيلوف مان و إيلوف ويت هؤلاء الأسطورة في
+
+913
+00:59:21,990 --> 00:59:25,850
+جزورها لا يدفعون تكسف إذا كانت لديك عملك في هؤلاء
+
+914
+00:59:25,850 --> 00:59:29,990
+الأسطورة لا تدفعك تكسف لديك عملك في لندن فالتكسف
+
+915
+00:59:29,990 --> 00:59:34,750
+سيكون أعلى، سيكون أعلى، لذا أفضل طريقة لكي تعمل
+
+916
+00:59:34,750 --> 00:59:39,330
+مثل هذا هي أنك تحتاج إلى مجلس، تحتاج إلى شخص، في
+
+917
+00:59:39,330 --> 00:59:43,410
+الولايات المتحدة يسمونهم Solicitors ويختارون
+
+918
+00:59:43,410 --> 00:59:49,570
+الأفضلالأفضل نوع من الشركات لأننا اذا كنا نحب الان
+
+919
+00:59:49,570 --> 00:59:54,670
+تخيل ان نحن نريد ان نعمل عمل نفس نفس نفس نفس نفس
+
+920
+00:59:54,670 --> 00:59:54,710
+نفس نفس نفس نفس نفس نفس نفس نفس نفس نفس نفس نفس
+
+921
+00:59:54,710 --> 00:59:55,190
+نفس نفس نفس نفس نفس نفس نفس نفس نفس نفس نفس نفس
+
+922
+00:59:55,190 --> 00:59:56,430
+نفس نفس نفس نفس نفس نفس نفس نفس نفس نفس نفس نفس
+
+923
+00:59:56,430 --> 00:59:57,050
+نفس نفس نفس نفس نفس نفس نفس نفس نفس نفس نفس نفس
+
+924
+00:59:57,050 --> 01:00:02,830
+نفس نفس نفس نفس نفس نفس نفس نفس نفس
+
+925
+01:00:02,830 --> 01:00:03,770
+نفس نفس نفس نفس نفس نفس نفس نفس نفس نفس نفس نفس
+
+926
+01:00:03,770 --> 01:00:05,510
+نفس نفس نفس نفس نفس نفس نفس نفس نفس نفس نفس نفس
+
+927
+01:00:05,510 --> 01:00:13,090
+نفس نفس نفس نفس نفس نفس
+
+928
+01:00:13,090 --> 01:00:17,810
+نهو سيكون عمل فقط في غزا أو هل يمكن أن يعمل في
+
+929
+01:00:17,810 --> 01:00:21,450
+الخارج في إيجابا أو بأخر الدول؟ لذلك يجب أن ننظر
+
+930
+01:00:21,450 --> 01:00:25,410
+إلى احتاجاتنا وما يجب أن نفعله ويجب أن ننظر إلى
+
+931
+01:00:25,410 --> 01:00:28,950
+الوصفات المتوفرة والشركات الموجودة في فلسطين ومن
+
+932
+01:00:28,950 --> 01:00:32,210
+ثم نستطيع أن نشارك ما يوجد في عقبتنا ومشروعاتنا
+
+933
+01:00:32,210 --> 01:00:36,190
+ومشروعات الشركات الموجودة في فلسطين ومشروعات
+
+934
+01:00:36,190 --> 01:00:36,370
+الشركات الموجودة في فلسطين ومشروعات الشركات
+
+935
+01:00:36,370 --> 01:00:37,110
+الموجودة في فلسطين ومشروعات الشركات الموجودة في
+
+936
+01:00:37,110 --> 01:00:41,510
+فلسطين ومشروعات
+
+937
+01:00:41,510 --> 01:00:44,170
+الشركات الموجودة في فلسط
+
diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/DjHtglwoCBg_postprocess.srt b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/DjHtglwoCBg_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..43485274d5f9b817e8f48c84282d07dad29b9548
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/DjHtglwoCBg_postprocess.srt
@@ -0,0 +1,3668 @@
+1
+00:00:14,080 --> 00:00:17,860
+طيب بسم الله الرحمن الرحيم we just completing what
+
+2
+00:00:17,860 --> 00:00:21,260
+we had in the same chapter still talking about
+
+3
+00:00:21,260 --> 00:00:24,600
+contracts today we have to use the mic you can
+
+4
+00:00:24,600 --> 00:00:27,830
+speak upYou can answer questions, you can make
+
+5
+00:00:27,830 --> 00:00:30,730
+your own comment and you can read from the slides
+
+6
+00:00:30,730 --> 00:00:36,710
+We still talk about the terms And we said term is
+
+7
+00:00:36,710 --> 00:00:40,950
+any provision .. a term is any provision forming
+
+8
+00:00:40,950 --> 00:00:43,990
+part of the contract Now if we have the contract
+
+9
+00:00:43,990 --> 00:00:47,650
+We
+
+10
+00:00:47,650 --> 00:00:52,480
+have termsthese terms can be titles quality
+
+11
+00:00:52,480 --> 00:00:56,560
+description can be names can be price it can be
+
+12
+00:00:56,560 --> 00:01:00,520
+anything these terms can be included in the
+
+13
+00:01:00,520 --> 00:01:07,800
+contract in I mean they can be expressed statedin
+
+14
+00:01:07,800 --> 00:01:10,860
+the contract itself some of the some of the terms
+
+15
+00:01:10,860 --> 00:01:14,560
+can be implied but those implicit contracts
+
+16
+00:01:14,560 --> 00:01:18,500
+implicit contracts forming part of the contract
+
+17
+00:01:18,500 --> 00:01:21,620
+despite the fact they are not stated in the
+
+18
+00:01:21,620 --> 00:01:26,760
+contract like we having some students but those
+
+19
+00:01:26,760 --> 00:01:32,430
+students they're not here today they are absentfor
+
+20
+00:01:32,430 --> 00:01:36,170
+some reasons they are not attending the class but
+
+21
+00:01:36,170 --> 00:01:38,710
+those students are part of the class they can come
+
+22
+00:01:38,710 --> 00:01:42,650
+next time but today we have about seventeen
+
+23
+00:01:42,650 --> 00:01:45,530
+eighteen students or twenty but we have twenty
+
+24
+00:01:45,530 --> 00:01:48,110
+five students in this class I mean we cannot
+
+25
+00:01:48,110 --> 00:01:51,890
+exclude those five students who are absent for
+
+26
+00:01:51,890 --> 00:01:55,810
+some reasons all of them are included did we
+
+27
+00:01:55,810 --> 00:01:59,790
+finish this slide last time okay we have explicit
+
+28
+00:02:01,160 --> 00:02:04,540
+terms and implicit terms as I said again those
+
+29
+00:02:04,540 --> 00:02:09,040
+implicit terms we can understand them that they
+
+30
+00:02:09,040 --> 00:02:12,680
+constitute part of the contract despite the fact
+
+31
+00:02:12,680 --> 00:02:17,820
+they are not stated in the contract we can
+
+32
+00:02:17,820 --> 00:02:22,520
+understand them by the de facto situation we can
+
+33
+00:02:22,520 --> 00:02:26,380
+understand them from the proceduresمن التعاملات
+
+34
+00:02:26,380 --> 00:02:31,300
+السابقة من .. من القانون كما سنرى الأن إذا كنت
+
+35
+00:02:31,300 --> 00:02:34,180
+تنظر هنا في هذه الصفحة لدينا الكثير من التعاملات
+
+36
+00:02:34,180 --> 00:02:38,840
+في التعاملات المطلوبة من القانون هل لدينا هذه
+
+37
+00:02:38,840 --> 00:02:43,260
+الصفحة أو لا؟ هل انتهينا منها؟ جيد، حسنًا مطلوبwe
+
+38
+00:02:43,260 --> 00:02:47,260
+have implied terms in law implied in law terms
+
+39
+00:02:47,260 --> 00:02:51,940
+these terms as we had last time are not stated in
+
+40
+00:02:51,940 --> 00:02:56,260
+the contract but they are stated in the act in a
+
+41
+00:02:56,260 --> 00:03:00,400
+commercial act we understand those terms as part
+
+42
+00:03:00,400 --> 00:03:03,340
+of the contract like an example we had last time
+
+43
+00:03:03,340 --> 00:03:08,480
+the sale of goods act 1979 sale of goods act 1979
+
+44
+00:03:08,480 --> 00:03:13,390
+this is an act which was made in the UK in 1979and
+
+45
+00:03:13,390 --> 00:03:18,310
+its focus is on sale and because we know that sale
+
+46
+00:03:18,310 --> 00:03:24,970
+it's the most common contract sale now this act is
+
+47
+00:03:24,970 --> 00:03:30,070
+implicit in any contract unless if we here execute
+
+48
+00:03:30,070 --> 00:03:34,870
+it can we yes next chapter we're going to see that
+
+49
+00:03:34,870 --> 00:03:39,410
+in some cases we can exclude what can we exclude
+
+50
+00:03:39,410 --> 00:03:41,730
+terms
+
+51
+00:03:42,900 --> 00:03:47,860
+we can because we have sources for commercial law
+
+52
+00:03:47,860 --> 00:03:52,160
+source number one is contract source number two is
+
+53
+00:03:52,160 --> 00:03:57,740
+the act the code the law so we look first of all
+
+54
+00:03:57,740 --> 00:04:02,660
+at this contract because what can what can commit
+
+55
+00:04:02,660 --> 00:04:07,930
+meand you is the contract it's an obligation for
+
+56
+00:04:07,930 --> 00:04:12,030
+both parties a and b have some obligations because
+
+57
+00:04:12,030 --> 00:04:15,070
+of the contract they have signed so I would come
+
+58
+00:04:15,070 --> 00:04:18,590
+back if I have conflict with someone else I would
+
+59
+00:04:18,590 --> 00:04:22,030
+come back to the contract I would look what's
+
+60
+00:04:22,030 --> 00:04:25,870
+stated inside the contract and outside it what we
+
+61
+00:04:25,870 --> 00:04:31,170
+have here these can be the rules which we have to
+
+62
+00:04:31,170 --> 00:04:35,430
+accept and we have to use in our lifeإذا لم نستطيع
+
+63
+00:04:35,430 --> 00:04:38,950
+أن نجد حل في المقاومة، فيمكننا أن نذهب إلى الـ Act
+
+64
+00:04:38,950 --> 00:04:43,390
+هذا الـ Act يمكن أن يكون قانون مجتمع كما هو يمكن
+
+65
+00:04:43,390 --> 00:04:47,070
+أن يكون في بعض الأحيان قواعد محددة أو قواعد محددة
+
+66
+00:04:47,070 --> 00:04:51,530
+أو كود بعضهم يمكن أن يكون لسائق الأسعار، بعضهم
+
+67
+00:04:51,530 --> 00:04:55,790
+يمكن أن يكون مثل ما حدث للمرة الأخيرة يمكن أن يكون
+
+68
+00:04:55,790 --> 00:04:57,750
+لأشياء أخرى مثل التعامل، تعامل التعامل التعامل
+
+69
+00:04:57,750 --> 00:04:58,490
+التعامل التعامل التعامل التعامل التعامل التعامل
+
+70
+00:04:58,490 --> 00:05:00,210
+التعامل التعامل التعامل التعامل التعامل التعامل
+
+71
+00:05:00,210 --> 00:05:00,830
+التعامل التعامل التعامل التعامل التعامل التعامل
+
+72
+00:05:00,830 --> 00:05:05,410
+التعاملمن الكثير من الناس من الكثير من الناس أو من
+
+73
+00:05:05,410 --> 00:05:09,030
+الكثير من المجالات من الحياة التجارية يجب أن نعود
+
+74
+00:05:09,030 --> 00:05:14,010
+إلى حركتها نفسها إلى القواعد إذا لم نستطيع أن نجد
+
+75
+00:05:14,010 --> 00:05:18,290
+حلولة في التطبيق هذا ما يسمى بـimplied in law
+
+76
+00:05:18,290 --> 00:05:21,730
+أعتقد هل انتهينا؟ نعم ننتهي من هذا اليوم يجب أن
+
+77
+00:05:21,730 --> 00:05:30,030
+ننظر إلى كيف يمكننا أن نجلس خارج التطبيق أعتقد
+
+78
+00:05:30,030 --> 00:05:35,090
+أننا بدأنا بهذا السابقI was asking you said 21
+
+79
+00:05:35,090 --> 00:05:41,030
+okay that's fine no problem what we finish 22
+
+80
+00:05:41,030 --> 00:05:45,850
+slide 22 okay how can we set aside the contract we
+
+81
+00:05:45,850 --> 00:05:49,150
+said from the beginning that we assume that this
+
+82
+00:05:49,150 --> 00:05:55,070
+contract is intact it's legal it's fully accepted
+
+83
+00:05:55,070 --> 00:05:59,330
+by both parties a and b both parties signed the
+
+84
+00:05:59,330 --> 00:06:03,220
+contract they completed itaccording to their own
+
+85
+00:06:03,220 --> 00:06:05,840
+wills they have their intentions offer an
+
+86
+00:06:05,840 --> 00:06:08,540
+acceptance consideration everything wasn't in
+
+87
+00:06:08,540 --> 00:06:12,440
+place and everything was perfect in this
+
+88
+00:06:12,440 --> 00:06:16,300
+perfection situation perfect situation can we set
+
+89
+00:06:16,300 --> 00:06:18,860
+aside a contract maybe
+
+90
+00:06:20,550 --> 00:06:23,670
+نحن لدينا ثلاث حالات مختلفة فيها واحدة منها يمكن
+
+91
+00:06:23,670 --> 00:06:28,110
+أن تكون مفتوحاً منذ البداية، هذا التجارب يمكن أن
+
+92
+00:06:28,110 --> 00:06:32,990
+يكون مفتوحاً لأنه لم يكن موجود من اللحظة الأولى،
+
+93
+00:06:32,990 --> 00:06:37,770
+هذه الحالة فيها أننا خسرنا واحد من الواضحين، ربما
+
+94
+00:06:37,770 --> 00:06:44,520
+لم يكن هناك اهتماملا اعتماد، ربما الاسماء لم
+
+95
+00:06:44,520 --> 00:06:47,680
+تتنافس بالقوة التي كانت تحتاجها القوة التي كانت
+
+96
+00:06:47,680 --> 00:06:52,580
+تحتاجها القوة التي كانت تحتاجها القوة التي كانت
+
+97
+00:06:52,580 --> 00:06:55,600
+تحتاجها
+
+98
+00:06:55,600 --> 00:06:58,760
+القوة التي كانت تحتاجها القوة التي كانت تحتاجها
+
+99
+00:06:58,760 --> 00:06:59,300
+القوة التي كانت تحتاجها القوة التي كانت تحتاجها
+
+100
+00:06:59,300 --> 00:06:59,460
+القوة التي كانت تحتاجها القوة التي كانت تحتاجها
+
+101
+00:06:59,460 --> 00:07:00,720
+القوة التي كانت تحتاجها القوة التي كانت تحتاجها
+
+102
+00:07:00,720 --> 00:07:06,160
+القوة
+
+103
+00:07:06,160 --> 00:07:11,230
+التي كانأي واحد منهم يستطيع أن يدفع قرار غير مفيد،
+
+104
+00:07:11,230 --> 00:07:15,690
+غير مفيد في حاجتهم، أي واحد منهم يستطيع أن يقول،
+
+105
+00:07:15,690 --> 00:07:21,090
+هذا القرار انتهى، لسنا نحتاجه بعد الأن، لماذا؟
+
+106
+00:07:21,090 --> 00:07:25,730
+لأننا لدينا بعض الحالات التي يمكن أن تؤثر على هذا
+
+107
+00:07:25,730 --> 00:07:31,110
+القرار كما سنرى في الفيديو التالف ثالث جزء هو
+
+108
+00:07:31,110 --> 00:07:36,760
+القرار غير مفيد، يمكن أن يكون القرار غير مفيدif
+
+109
+00:07:36,760 --> 00:07:41,640
+this contract here is affected by a situation like
+
+110
+00:07:41,640 --> 00:07:48,420
+if it was illegal I mean the subject the purpose
+
+111
+00:07:48,420 --> 00:07:52,700
+was illegal of this contract this contract even if
+
+112
+00:07:52,700 --> 00:07:56,240
+it's fine if it's okay if it's perfect but the
+
+113
+00:07:56,240 --> 00:07:58,820
+purpose of the contract was illegal then this
+
+114
+00:07:58,820 --> 00:08:03,100
+contract cannot be enforced like someone selling
+
+115
+00:08:03,100 --> 00:08:11,000
+drugs الكحولأو أسلحة، شيء غير حقيقي، شيء لم يكن من
+
+116
+00:08:11,000 --> 00:08:16,080
+المفترض أن يكون فعله، و الوضع نفسه بخير، لكن الـ
+
+117
+00:08:16,080 --> 00:08:19,100
+pairbus لم يكن بخير، ال pairbus كانت ضد حكومة
+
+118
+00:08:19,100 --> 00:08:24,740
+عامة، في هذه الحالة، هذا الوضع سيكون غير مدفع،
+
+119
+00:08:24,740 --> 00:08:28,480
+عندما نصل إلى هذا النقطة، سنتحدث عنه بمزيد من
+
+120
+00:08:28,480 --> 00:08:32,000
+التفاصيل، مثلًا، سحب السلاسل، هل نستطيع أن نسحب
+
+121
+00:08:32,000 --> 00:08:36,290
+السلاسل؟because this is against public interest
+
+122
+00:08:36,290 --> 00:08:41,630
+it's illegal it's a criminal case then now if even
+
+123
+00:08:41,630 --> 00:08:44,170
+if there is a contract this contract would be
+
+124
+00:08:44,170 --> 00:08:48,610
+unenforceable no one can force it let's look at
+
+125
+00:08:48,610 --> 00:08:52,490
+the first situation I don't know I have a feeling
+
+126
+00:08:52,490 --> 00:08:56,550
+that I did explain this well that's fine no
+
+127
+00:08:56,550 --> 00:08:59,510
+problem because other class mainly class students
+
+128
+00:08:59,510 --> 00:09:02,630
+are still behind you don't willingly
+
+129
+00:09:08,150 --> 00:09:13,070
+you've done it? it's okay و دلوقت ايه؟ the first
+
+130
+00:09:13,070 --> 00:09:19,010
+case is misrepresentation in which we can define
+
+131
+00:09:19,010 --> 00:09:21,470
+it we can define it as you look at this I need
+
+132
+00:09:21,470 --> 00:09:23,970
+someone to read it for me anyone of you anyone
+
+133
+00:09:23,970 --> 00:09:28,330
+here because we have the mic go on speak up
+
+134
+00:09:28,330 --> 00:09:31,370
+misrepresentation is a statement of a fact made by
+
+135
+00:09:31,370 --> 00:09:37,440
+one party to another and has the effect ofinducing
+
+136
+00:09:37,440 --> 00:09:42,220
+.. inducing .. inducing يحث أو يدفع inducing that
+
+137
+00:09:42,220 --> 00:09:46,200
+party into the contract it's a false statement and
+
+138
+00:09:46,200 --> 00:09:48,160
+I mentioned last time it's a false statement of
+
+139
+00:09:48,160 --> 00:09:53,560
+fact this false statement of fact made by one
+
+140
+00:09:53,560 --> 00:09:57,120
+party to the other and this false statement of
+
+141
+00:09:57,120 --> 00:10:01,020
+fact made the second party to accept the contract
+
+142
+00:10:01,860 --> 00:10:06,680
+إذا لم يكن هناك مصطلح من البداية، فلن يكون هناك
+
+143
+00:10:06,680 --> 00:10:12,740
+مصطلح بدون هذا المصطلح، بدون هذا المصطلح، لن يقبل
+
+144
+00:10:12,740 --> 00:10:15,260
+الحكومة الثانوية، لذا مصطلح الـ False statement of
+
+145
+00:10:15,260 --> 00:10:20,720
+fact هو السبب لماذا الحكومة الثانوية قامت بإصلاحه،
+
+146
+00:10:20,720 --> 00:10:27,520
+تدفع، تدفع الحكومة الثانوية لإقباله، لإصلاحه هذا
+
+147
+00:10:27,520 --> 00:10:29,700
+التمييز من مصطلح الـ False statement يمكن أن يكون
+
+148
+00:10:29,700 --> 00:10:30,680
+مصطلح الـ False statement
+
+149
+00:10:33,380 --> 00:10:41,240
+description مثل شخص يحكي عن القوة، شخص يحكي عن قوة
+
+150
+00:10:41,240 --> 00:10:49,380
+المشركة، الأشياء، شخص لم يعطي معلومات صحيحة عن ..
+
+151
+00:10:49,380 --> 00:10:55,280
+عن التشريح، الطبيعة أعتقد أنني أعطي مثلًا عن
+
+152
+00:10:55,280 --> 00:11:00,400
+الملح، الملح، السمك، الشجر، حتى في الأشياء
+
+153
+00:11:00,400 --> 00:11:05,280
+اللازمة، لدينا إيقافات مختلفةالشيء نفسه مثل
+
+154
+00:11:05,280 --> 00:11:08,920
+الكمبيوتر، كم نوع من الكمبيوتر اللي لدينا؟ كم قيمة
+
+155
+00:11:08,920 --> 00:11:14,440
+لدينا؟ مئات، ليسوا نفس القيمة، لذلك بشراء كمبيوتر
+
+156
+00:11:14,440 --> 00:11:18,180
+لا يعني أنني أستطيع أشتري أي كمبيوتر في السوق، بل
+
+157
+00:11:18,180 --> 00:11:21,060
+أستطيع أن أختار القيمة اللي أريدها، أستطيع أن
+
+158
+00:11:21,060 --> 00:11:25,580
+أختار المصطلح والطبيعة، فهذا هو الحال هنا، إذا كان
+
+159
+00:11:25,580 --> 00:11:30,640
+لدينا مصطلح غير صحيح في القيمة، فسيكون الشركة
+
+160
+00:11:30,640 --> 00:11:36,460
+الثانية لديها حق لماذا؟انظر إلى هذه اللحظة إيجاد
+
+161
+00:11:36,460 --> 00:11:42,740
+غيرمثابق يسمح بإعادة التعامل اتفاق أو تسبب تدمير
+
+162
+00:11:42,740 --> 00:11:50,480
+اتفاق تتخلص من التعامل او اتفاق تتخلص من التعامل
+
+163
+00:11:50,480 --> 00:11:54,660
+اتفاق تتخلص من التعامل اتفاق تتخلص من التعامل
+
+164
+00:11:54,660 --> 00:11:58,880
+اتفاق تتخلص من التعامل اتفاق تتخلص من التعامل
+
+165
+00:11:58,880 --> 00:12:00,000
+اتفاق تتخلص من التعامل اتفاق تتخلص من التعامل
+
+166
+00:12:00,000 --> 00:12:03,880
+اتفاق تتخلص من التعاملcausing damages getting
+
+167
+00:12:03,880 --> 00:12:08,420
+money compensation compensation misrepresentation
+
+168
+00:12:08,420 --> 00:12:12,140
+can be by words it can be by conduct it can be by
+
+169
+00:12:12,140 --> 00:12:16,460
+actions it can be by implicit acts by implicit
+
+170
+00:12:16,460 --> 00:12:20,240
+acts and i guess that we have the last point which
+
+171
+00:12:20,240 --> 00:12:24,580
+was about the statement of opinion it's not like
+
+172
+00:12:24,580 --> 00:12:28,000
+the statement of fact it's not the same someone
+
+173
+00:12:28,000 --> 00:12:32,220
+giving a statement of opinion someonestating his
+
+174
+00:12:32,220 --> 00:12:36,040
+opinion by saying well I think or I believe that
+
+175
+00:12:36,040 --> 00:12:41,240
+this item has a specific equality and he stated
+
+176
+00:12:41,240 --> 00:12:45,640
+that equality in this case here statement of
+
+177
+00:12:45,640 --> 00:12:48,520
+opinion does not stand like a statement of fact
+
+178
+00:12:48,520 --> 00:12:51,600
+it's not a fact when saying that well I believe
+
+179
+00:12:51,600 --> 00:12:57,180
+that this bottle it's not water inside it it's a
+
+180
+00:12:57,180 --> 00:13:01,220
+gas petrolit's just my opinion I don't know I'm
+
+181
+00:13:01,220 --> 00:13:05,980
+not really sure it's my opinion then you cannot
+
+182
+00:13:05,980 --> 00:13:09,660
+take this as a fact you can take it as opinion I
+
+183
+00:13:09,660 --> 00:13:14,020
+can tell or I can say well this color of this hole
+
+184
+00:13:14,020 --> 00:13:17,440
+looks really nice I like it but some of you would
+
+185
+00:13:17,440 --> 00:13:21,100
+say well no it does not it doesn't look good it's
+
+186
+00:13:21,100 --> 00:13:23,400
+an opinion at the end of the day it's not a fact
+
+187
+00:13:23,400 --> 00:13:31,120
+so this opinion cannot be used cannot be usedلتنقل
+
+188
+00:13:31,120 --> 00:13:35,160
+التقرير لا يمكن أن يكون استخدامه لتحقيقه لأن شخص
+
+189
+00:13:35,160 --> 00:13:40,120
+يعطي نفسه فكرة ثانية حتى إذا كان يعتمد على ذلك
+
+190
+00:13:40,120 --> 00:13:45,580
+انتهى منه يمكنك تحقق يمكنك تحقق الأشياء يمكنك أن
+
+191
+00:13:45,580 --> 00:13:50,420
+تبحث عن التعاملات لا يجب أن تعتمد على ما يقوله إنه
+
+192
+00:13:50,420 --> 00:13:56,660
+نفسه فكرة حتى إذا كان لدينا هنا معرفة خاصة
+
+193
+00:13:58,640 --> 00:14:03,580
+making his own opinion build or based on special
+
+194
+00:14:03,580 --> 00:14:06,660
+not fact it's not a fact it's opinion special
+
+195
+00:14:06,660 --> 00:14:11,080
+knowledge someone is expert like for example
+
+196
+00:14:11,080 --> 00:14:16,000
+technician car technician buying a car and the one
+
+197
+00:14:16,000 --> 00:14:18,900
+who sold you the car he is a car technician or
+
+198
+00:14:18,900 --> 00:14:21,360
+somebody selling computers and he's a computer
+
+199
+00:14:21,360 --> 00:14:25,510
+engineer and he's a specialist inin repairing
+
+200
+00:14:25,510 --> 00:14:28,410
+computers then you can depend on what he says to
+
+201
+00:14:28,410 --> 00:14:31,870
+you like this is a good computer and has a good
+
+202
+00:14:31,870 --> 00:14:35,790
+quality and you depend on what he says this case
+
+203
+00:14:35,790 --> 00:14:40,170
+here his opinion can be taken as a statement of
+
+204
+00:14:40,170 --> 00:14:44,890
+fact in fact it was not a statement of fact but it
+
+205
+00:14:44,890 --> 00:14:48,110
+can be it can be taken as a statement of fact
+
+206
+00:14:48,110 --> 00:14:52,870
+because this knowledge is equal to the fact do you
+
+207
+00:14:52,870 --> 00:14:53,390
+get the point
+
+208
+00:14:56,900 --> 00:14:59,260
+هو يمكن أن يكون استخدامه كثير من الوثيقة فمن
+
+209
+00:14:59,260 --> 00:15:00,740
+يستخدمه كثير من الوثيقة فمن يستخدمه كثير من
+
+210
+00:15:00,740 --> 00:15:02,200
+الوثيقة فمن يستخدمه كثير من الوثيقة فمن يستخدمه
+
+211
+00:15:02,200 --> 00:15:04,260
+كثير من الوثيقة فمن يستخدمه كثير من الوثيقة فمن
+
+212
+00:15:04,260 --> 00:15:06,040
+يستخدمه كثير من الوثيقة فمن يستخدمه كثير من
+
+213
+00:15:06,040 --> 00:15:10,960
+الوثيقة فمن يستخدمه كثير من الوثيقة فمن يستخدمه
+
+214
+00:15:10,960 --> 00:15:16,420
+كثير من الوثيقة فمن يستخدمه كثير من الوثيقة فمن
+
+215
+00:15:16,420 --> 00:15:22,280
+يستخدمه كثير من الوثيقة فمن يستخدمه كثير
+
+216
+00:15:22,280 --> 00:15:26,420
+من الوثيقة فمن يستخدمه كثير من
+
+217
+00:15:34,980 --> 00:15:42,480
+الثاني الموضوع هنا هو خطأ أحدهم يستطيع أن يفعل خطأ
+
+218
+00:15:42,480 --> 00:15:51,040
+في مجلسه أحدهم كم مرات نعمل مجلس في حياتنا؟
+
+219
+00:15:51,040 --> 00:15:56,190
+ملايين، ربما ملايين ملايين، مليون مجلسممكن على
+
+220
+00:15:56,190 --> 00:16:01,530
+مستوى يومي يعملوا مقالات، إذا كنت شرطي و لديك شركة
+
+221
+00:16:01,530 --> 00:16:05,390
+في السوق، فيمكنك أن تعمل مقالات على مستوى يومي،
+
+222
+00:16:05,390 --> 00:16:12,710
+ألف مقالات مع الكثير من المستخدمين، فهل لدينا خطأ؟
+
+223
+00:16:12,710 --> 00:16:16,490
+بالطبع لدينا خطأ، و أحيانًا تشتري شيء و تحصل على
+
+224
+00:16:16,490 --> 00:16:19,330
+أكتر المال أو تحصل على أقل من المال الذي فات
+
+225
+00:16:20,210 --> 00:16:22,950
+Sometimes you get the exchange, to exchange the
+
+226
+00:16:22,950 --> 00:16:26,450
+item, but then the item you exchange here, you
+
+227
+00:16:26,450 --> 00:16:30,470
+replace it, it's not the thing you want Sometimes
+
+228
+00:16:30,470 --> 00:16:33,670
+even the size you're looking for, you would like
+
+229
+00:16:33,670 --> 00:16:36,590
+to buy a dress, the size you're looking for, it's
+
+230
+00:16:36,590 --> 00:16:40,250
+not the size you had from that shop, you can't
+
+231
+00:16:40,250 --> 00:16:43,290
+take it back, I mean you can imagine that many
+
+232
+00:16:43,290 --> 00:16:46,430
+mistakes can happenthe items, the machine, the
+
+233
+00:16:46,430 --> 00:16:53,790
+food, any item we can sell, we can buy can have a
+
+234
+00:16:53,790 --> 00:16:55,790
+mistake, we can have a mistake but this mistake we
+
+235
+00:16:55,790 --> 00:16:59,930
+can define it as incorrect understanding go on
+
+236
+00:16:59,930 --> 00:17:03,570
+Jayda a mistake is an incorrect understanding by
+
+237
+00:17:03,570 --> 00:17:06,410
+one or more party to a contract and may be used as
+
+238
+00:17:06,410 --> 00:17:10,170
+a base to invalidate the agreement okay mistake
+
+239
+00:17:10,170 --> 00:17:14,230
+can be done by one or by twoمن جميعهم، من جميع
+
+240
+00:17:14,230 --> 00:17:16,870
+الشركات، ولكن هذا الخطأ يمكن أن يكون استخدامه
+
+241
+00:17:16,870 --> 00:17:21,950
+لإفعالة التطبيق، يمكن أن يكون استخدامه لإصلاح هذا
+
+242
+00:17:21,950 --> 00:17:26,930
+التطبيق كما لو لم يكن هناك، لإنهاءه، لإنهاءه،
+
+243
+00:17:26,930 --> 00:17:30,010
+لإفعالة هذا التطبيق، لإنهاءه، لإنهاءه، لإنهاءه،
+
+244
+00:17:30,010 --> 00:17:35,130
+لإنهاءه، لإنهاءه، لإنهاءه، لإنهاءه، لإنهاءه، لإ
+
+245
+00:17:36,020 --> 00:17:39,760
+الثاني هو mutual mystique والثالث هو common
+
+246
+00:17:39,760 --> 00:17:44,600
+mystique دعنا نبدأ مع الرقم واحد unilateral
+
+247
+00:17:44,600 --> 00:17:51,140
+mystique انه مصنع من واحد شركة فقط واحد unilateral
+
+248
+00:17:51,140 --> 00:17:57,740
+أحادي unilateral mystique هو شركة واحدة مصنعة مع
+
+249
+00:17:57,740 --> 00:18:00,510
+شركة واحدةone has made a mistake it can be the
+
+250
+00:18:00,510 --> 00:18:03,850
+seller it can be the buyer it can be the wholesale
+
+251
+00:18:03,850 --> 00:18:08,710
+merchant it can be the retail merchant it can be
+
+252
+00:18:08,710 --> 00:18:12,370
+anyone making the mistake one party not the second
+
+253
+00:18:12,370 --> 00:18:16,630
+not the second what can we do in this case look
+
+254
+00:18:16,630 --> 00:18:19,970
+imagine yourself as a judge and you have two
+
+255
+00:18:19,970 --> 00:18:24,830
+parties having conflicts one of them has made a
+
+256
+00:18:24,830 --> 00:18:29,730
+mistake and by the seconddid not and now there is
+
+257
+00:18:29,730 --> 00:18:31,950
+something wrong in this contract, how can we solve
+
+258
+00:18:31,950 --> 00:18:36,910
+it؟ if the other party .. if the mistaken party ..
+
+259
+00:18:36,910 --> 00:18:42,030
+if the other party was knowing of the .. if the
+
+260
+00:18:42,030 --> 00:18:45,510
+other party is .. has a mistake and he's kept
+
+261
+00:18:45,510 --> 00:18:49,440
+silent and showing him and he ..يعني he get the
+
+262
+00:18:49,440 --> 00:18:53,340
+advantages of his mistake that the court can
+
+263
+00:18:53,340 --> 00:18:56,500
+default or can breach the contract and there is no
+
+264
+00:18:56,500 --> 00:18:59,860
+moving contract I think like she says there are
+
+265
+00:18:59,860 --> 00:19:03,080
+many phases of this situation, first of all they
+
+266
+00:19:03,080 --> 00:19:08,100
+have negotiated between themselves and then turned
+
+267
+00:19:08,100 --> 00:19:15,510
+to court and judgeو في هذه اللحظة، كما قلت، إذا
+
+268
+00:19:15,510 --> 00:19:19,630
+كانت المجلد عارفة عن حالة المخطط، لا يمكن أن يتم
+
+269
+00:19:19,630 --> 00:19:25,670
+إعادة أو تنظيمها كأكثر حالة في الحكومة ستقبلها،
+
+270
+00:19:25,670 --> 00:19:31,910
+تدعمها، تقبلها، تقبلها، تقبلها، تقبلها، تقبلها،
+
+271
+00:19:31,910 --> 00:19:32,630
+تقبلها، تقبلها، تقبلها، تقبلها، تقبلها، تقبلها،
+
+272
+00:19:32,630 --> 00:19:32,790
+تقبلها، تقبلها، تقبلها، تقبلها، تقبلها، تقبلها،
+
+273
+00:19:32,790 --> 00:19:33,030
+تقبلها، تقبلها، تقبلها، تقبلها، تقبلها، تقبلها،
+
+274
+00:19:33,030 --> 00:19:36,530
+تقبلها، تقبلها، تقبلها، تقبلها، تقبلها، تقبلها،
+
+275
+00:19:36,530 --> 00:19:41,470
+تقبلها،we can .. we can amend .. we can delete
+
+276
+00:19:41,470 --> 00:19:44,690
+some of the terms we have to uphold such contracts
+
+277
+00:19:44,690 --> 00:19:48,470
+uphold يدعم يسند we have to keep this contract
+
+278
+00:19:48,470 --> 00:19:51,970
+because we cannot .. we should not cancel such a
+
+279
+00:19:51,970 --> 00:19:54,850
+contract especially if it costs lots of money if
+
+280
+00:19:54,850 --> 00:19:58,650
+this contract existed between the two parties and
+
+281
+00:19:58,650 --> 00:20:02,090
+it's about a transaction which costs millions or
+
+282
+00:20:02,090 --> 00:20:04,630
+maybe thousands .. thousands of pounds then we
+
+283
+00:20:04,630 --> 00:20:08,830
+have to uphold such a contractيجب أن نحافظ عليه
+
+284
+00:20:08,830 --> 00:20:12,410
+بالطبع كل شيء يعتمد على الحرس يمكنه أن ينظر إلى
+
+285
+00:20:12,410 --> 00:20:17,730
+أفعال خارجية ينظر إلى حالة مفهومة ماذا يجب أن يفعل
+
+286
+00:20:17,730 --> 00:20:23,430
+في هذه الحالة بالطبع كل شيء يعتمد على حالة مفهومة
+
+287
+00:20:23,430 --> 00:20:28,710
+مفهومة في الماضي إذا كان لدينا قرار في الماضي و
+
+288
+00:20:28,710 --> 00:20:31,490
+كان لدينا نفس الحل يمكننا أن نأخذه يمكننا أن نصنع
+
+289
+00:20:31,490 --> 00:20:39,060
+حلية مخلوقية بنسبة لحقوق وإيقوة حقوق وإيقوةإلا أن
+
+290
+00:20:39,060 --> 00:20:43,520
+الحجر يستطيع أن يتأكد أن واحد منهم فعل خطأ هنا فهو
+
+291
+00:20:43,520 --> 00:20:49,080
+فعل خطأ هنا ولكن الجمهور الثاني يعرف عن ذلك وكان
+
+292
+00:20:49,080 --> 00:20:57,720
+مقفلًا لم يأخذ طريقًا لإيقاف وإيقاف الخطأ في هذه
+
+293
+00:20:57,720 --> 00:21:00,500
+الحالة سيستخدم الحكومة إلا إذا كان متأكدًا أن
+
+294
+00:21:00,500 --> 00:21:06,690
+الجمهور اللي لم يخطأ كان متأكد من الخطأand I try
+
+295
+00:21:06,690 --> 00:21:10,870
+to take advantage take advantage like for example
+
+296
+00:21:10,870 --> 00:21:19,750
+like going like buying buying buying cement I know
+
+297
+00:21:19,750 --> 00:21:23,590
+that people buying cement now from Egypt to Gaza
+
+298
+00:21:23,590 --> 00:21:29,110
+because they want to build houses now this cement
+
+299
+00:21:29,110 --> 00:21:31,970
+have different qualities you know this it's not
+
+300
+00:21:31,970 --> 00:21:36,260
+the same different qualitiesNow buying imagine
+
+301
+00:21:36,260 --> 00:21:40,360
+that me as a buyer buying twenty tons of cement
+
+302
+00:21:40,360 --> 00:21:44,540
+from Egypt and the seller he knew that the cement
+
+303
+00:21:44,540 --> 00:21:49,000
+I bought was not the same quality I wanted and I
+
+304
+00:21:49,000 --> 00:21:53,080
+didn't know I'm just a simple person I don't know
+
+305
+00:21:53,080 --> 00:21:56,500
+much about this cement and I've taken it I did not
+
+306
+00:21:56,500 --> 00:22:00,120
+examine it and I was gonna use it I was gonna use
+
+307
+00:22:00,120 --> 00:22:04,410
+it to build my towerثم بعد ذلك انا اكتشف ان هذا
+
+308
+00:22:04,410 --> 00:22:08,550
+البرنامج لم يتنافس بالقوة اللي اريتها. الان من
+
+309
+00:22:08,550 --> 00:22:12,770
+البداية، الجمهور الثاني، الجمهور المخطط، يعرف عن
+
+310
+00:22:12,770 --> 00:22:17,510
+ذلك، لكنه لم يخبرني عن ذلك. بقى مقفل. في هذه
+
+311
+00:22:17,510 --> 00:22:22,110
+الحالة هنا، انا استطيع أنقذه. انا استطيع أنقذه.
+
+312
+00:22:22,210 --> 00:22:24,510
+انا استطيع أنقذ .. انا استطيع .. انا استطيع .. انا
+
+313
+00:22:24,510 --> 00:22:25,130
+استطيع .. انا استطيع .. انا استطيع .. انا استطيع
+
+314
+00:22:25,130 --> 00:22:25,190
+.. انا استطيع .. انا استطيع .. انا استطيع .. انا
+
+315
+00:22:25,190 --> 00:22:27,530
+.. انا استطيع .. انا استطيع .. انا استطيع .. انا
+
+316
+00:22:27,530 --> 00:22:30,890
+استطيع
+
+317
+00:22:30,890 --> 00:22:34,540
+..هو ليس بسهولة، عليك أن تثبت أن المجلد الثاني،
+
+318
+00:22:34,540 --> 00:22:38,180
+المجلد المخطط لم يعرف عنه، وهو يبقى مخطط، وهذا ليس
+
+319
+00:22:38,180 --> 00:22:42,200
+حالة بسهولة، عليك أن تنظر إلى الهدف، إذا كان
+
+320
+00:22:42,200 --> 00:22:45,940
+المجلد الثاني لديه الهدف أو لا، إذا كان يعرف أو لا
+
+321
+00:22:45,940 --> 00:22:49,680
+يعرف، هذا ليس حالة بسهولة، أنا أعرف هذا، أعني يجب
+
+322
+00:22:49,680 --> 00:22:53,980
+أن ننظر إلى الحالة العامة ونحاول أن نحفظ هذا
+
+323
+00:22:53,980 --> 00:22:58,970
+التعامل ونحفظهوإذا لا نستطيع فلا نستطيع نستطيع أن
+
+324
+00:22:58,970 --> 00:23:01,950
+نتخلص منها كيف نستطيع .. كيف نستطيع أن نستخدم الحق
+
+325
+00:23:01,950 --> 00:23:05,290
+والإيقاف؟ كيف نستطيع أن نقوم بذلك؟ يجب أن نبحث عن
+
+326
+00:23:05,290 --> 00:23:09,670
+من هو الجمهور ومن الجمهور غير المخطط الجمهور جمهور
+
+327
+00:23:09,670 --> 00:23:14,330
+غير المخطط أخططتني في مدينة سيئة أتيت لقد فقدت
+
+328
+00:23:14,330 --> 00:23:18,830
+المال لكن كيف أستطيع أن أعاون نفسي؟ أستطيع أن أعود
+
+329
+00:23:18,830 --> 00:23:22,350
+إلى الجمهور الثاني، الجمهور غير المخطط و أستطيع ..
+
+330
+00:23:22,350 --> 00:23:24,990
+أستطيع .. نستطيع .. نستطيع أن ننظر على الوضع بينهم
+
+331
+00:23:26,310 --> 00:23:28,730
+we can take it from one person we can give it to
+
+332
+00:23:28,730 --> 00:23:32,170
+the second person we can look at this case and
+
+333
+00:23:32,170 --> 00:23:35,970
+apply justice but sometimes here we cannot approve
+
+334
+00:23:35,970 --> 00:23:40,010
+the case a mistake imagine any mistake can happen
+
+335
+00:23:40,010 --> 00:23:43,630
+in the contract here we have to fix it like we
+
+336
+00:23:43,630 --> 00:23:49,410
+have an example an example identity need somebody
+
+337
+00:23:49,410 --> 00:23:52,110
+to read it one here anyone of you
+
+338
+00:24:02,770 --> 00:24:06,750
+identity if there was mistake in the identity
+
+339
+00:24:06,750 --> 00:24:10,210
+شخصية
+
+340
+00:24:10,210 --> 00:24:13,830
+متعاقد you make a mistake sometimes in one of the
+
+341
+00:24:13,830 --> 00:24:18,950
+terms you make a mistake in the quality in the
+
+342
+00:24:18,950 --> 00:24:23,490
+price you make a mistake in locationyou make a
+
+343
+00:24:23,490 --> 00:24:26,350
+mistake in money aspects but some cases you make a
+
+344
+00:24:26,350 --> 00:24:30,250
+mistake in the identity of the second party does
+
+345
+00:24:30,250 --> 00:24:35,150
+it happen؟ yes how؟ by delivery transactions
+
+346
+00:24:35,150 --> 00:24:40,010
+deliver؟ how؟ what do you mean؟ if you are a
+
+347
+00:24:40,010 --> 00:24:43,250
+seller you want to deliver this certain product to
+
+348
+00:24:43,250 --> 00:24:46,950
+the customer who is the other party you deliver it
+
+349
+00:24:46,950 --> 00:24:49,110
+to someone else who didn't request this product
+
+350
+00:24:49,110 --> 00:24:51,210
+this extra product for example
+
+351
+00:24:55,610 --> 00:24:58,970
+or something like getting another personality and
+
+352
+00:24:58,970 --> 00:25:05,650
+buying something yes like انتحال شخصي yes انتحال
+
+353
+00:25:05,650 --> 00:25:12,210
+شخصي yes someone someone presuming that he is the
+
+354
+00:25:12,210 --> 00:25:16,750
+contracting party but he is not but this is not a
+
+355
+00:25:16,750 --> 00:25:20,310
+mistake a mistake can be done sometime it can be
+
+356
+00:25:20,310 --> 00:25:24,110
+like this it can be the what jada saidin this case
+
+357
+00:25:24,110 --> 00:25:26,610
+someone getting something does not belong to him
+
+358
+00:25:26,610 --> 00:25:29,990
+an item does not belong to me I should not take it
+
+359
+00:25:29,990 --> 00:25:33,330
+from the beginning one of the cases one of the
+
+360
+00:25:33,330 --> 00:25:36,610
+cases like this in was a mistaken identity a
+
+361
+00:25:36,610 --> 00:25:39,650
+mistaken identity it's not always about selling
+
+362
+00:25:39,650 --> 00:25:43,570
+and buying and even I can buy a service can he can
+
+363
+00:25:43,570 --> 00:25:48,270
+I yes I can buy a service from a company and this
+
+364
+00:25:48,270 --> 00:25:52,230
+company like for example having want to hire an
+
+365
+00:25:52,230 --> 00:25:56,550
+accountantI want to hire an accountant but I
+
+366
+00:25:56,550 --> 00:25:59,830
+wanted a female accountant she can speak French
+
+367
+00:25:59,830 --> 00:26:03,670
+and English at the same time from the beginning I
+
+368
+00:26:03,670 --> 00:26:08,030
+stated the purpose I want an accountant from your
+
+369
+00:26:08,030 --> 00:26:10,590
+company and this accountant can speak English and
+
+370
+00:26:10,590 --> 00:26:14,110
+French because she and it has to be she as well
+
+371
+00:26:14,110 --> 00:26:18,550
+not a man because she will be working in a female
+
+372
+00:26:19,310 --> 00:26:22,490
+city well .. well like with .. with some .. with
+
+373
+00:26:22,490 --> 00:26:27,010
+some females in a special private company like for
+
+374
+00:26:27,010 --> 00:26:29,910
+example hairdresser we have a company of
+
+375
+00:26:29,910 --> 00:26:34,110
+hairdresser coffee and we have all of those ladies
+
+376
+00:26:34,110 --> 00:26:37,550
+working like all of them females I cannot just get
+
+377
+00:26:37,550 --> 00:26:39,850
+a man to work in the middle in that company it has
+
+378
+00:26:39,850 --> 00:26:42,290
+to be a female she can speak English and French
+
+379
+00:26:42,290 --> 00:26:46,740
+because our customers speak English and Frenchthen
+
+380
+00:26:46,740 --> 00:26:49,640
+what can we do here؟ we have to have that person
+
+381
+00:26:49,640 --> 00:26:52,960
+and that specifications if the company sends me a
+
+382
+00:26:52,960 --> 00:26:57,120
+man I will not accept if the company sends me
+
+383
+00:26:57,120 --> 00:26:59,300
+somebody speaks English and does not speak French
+
+384
+00:26:59,300 --> 00:27:03,120
+I will not accept because the identity شخصية as
+
+385
+00:27:03,120 --> 00:27:09,700
+requested exactly it has to be here plaintiff
+
+386
+00:27:09,700 --> 00:27:15,990
+المشتكي plaintiff has to showit was if I was the
+
+387
+00:27:15,990 --> 00:27:21,010
+plain tea في المشتركي had to show that the
+
+388
+00:27:21,010 --> 00:27:26,450
+identity I wanted of the second party was of a
+
+389
+00:27:26,450 --> 00:27:30,110
+vital importance at the time I signed the contract
+
+390
+00:27:30,110 --> 00:27:32,850
+I would have to show from the beginning I cannot
+
+391
+00:27:32,850 --> 00:27:35,850
+say like I can sign a contract with you with your
+
+392
+00:27:35,850 --> 00:27:38,870
+company then later on say well oh I didn't mean
+
+393
+00:27:38,870 --> 00:27:43,510
+this I meant that I want someone to speak Hebrewأو
+
+394
+00:27:43,510 --> 00:27:47,790
+أحدهم يريد أن يتحدث بالإندي؟ لا، ليس كذلك، يجب أن
+
+395
+00:27:47,790 --> 00:27:51,610
+أقول من البداية، يجب أن يظهر بلينتيف أنه في وقت
+
+396
+00:27:51,610 --> 00:27:55,450
+الواقع، في وقت الواقع للتوافق، فإنه أصدقاء الآخرين
+
+397
+00:27:55,450 --> 00:28:01,870
+كانوا أهم مهمين في هذه الحالة، أستطيع أن أرفض،
+
+398
+00:28:01,870 --> 00:28:04,330
+أستطيع أن أنهي القواعد، أنا لا أستطيع أن أقول إنني
+
+399
+00:28:04,330 --> 00:28:08,880
+أريد المجاورة، لماذا؟أنا مخطط في الواقع الواقعي،
+
+400
+00:28:08,880 --> 00:28:13,880
+يجب أن أحصل الشركة الثانوية لإشتراك التطبيق معي في
+
+401
+00:28:13,880 --> 00:28:18,480
+نفس الهيئة و في نفس الهيئة التي طلبت منها، كما قلت
+
+402
+00:28:18,480 --> 00:28:22,420
+في التطبيق ولكنها
+
+403
+00:28:22,420 --> 00:28:26,320
+ليست مثل الاعتماد، إذا كنت مخطط في اعتماد الشركات
+
+404
+00:28:26,320 --> 00:28:31,800
+الأخرى، فهذا ليس كافي، مثلما أقول أن أعتقد أن
+
+405
+00:28:31,800 --> 00:28:35,120
+الشركة الثانوية ليس لديها اعتماد، فهذا هو السبب
+
+406
+00:28:35,120 --> 00:28:38,930
+لذلك أود أن أتخلص التطبيقhow can you assume
+
+407
+00:28:38,930 --> 00:28:43,190
+something like this even .. even though it's not
+
+408
+00:28:43,190 --> 00:28:45,170
+.. as long as the second party is dealing with me
+
+409
+00:28:45,170 --> 00:28:47,770
+in a nice way as long as the second party is
+
+410
+00:28:47,770 --> 00:28:52,750
+committed .. committed and she is doing her part
+
+411
+00:28:52,750 --> 00:28:57,070
+in the contract then I cannot .. I cannot allege
+
+412
+00:28:57,070 --> 00:29:01,050
+that she has no credibility it's up to her it's
+
+413
+00:29:01,050 --> 00:29:03,650
+her life her situation as long as she does
+
+414
+00:29:03,650 --> 00:29:06,390
+everything in accordance with the situation in the
+
+415
+00:29:06,390 --> 00:29:12,600
+contractthat's it it's done it's fine there is no
+
+416
+00:29:12,600 --> 00:29:19,440
+problem fine gone mistakes are mistakes necessary
+
+417
+00:29:19,440 --> 00:29:24,440
+to be on purpose no it's not mistake it's not it's
+
+418
+00:29:24,440 --> 00:29:26,920
+not something mistake is a mistake with no
+
+419
+00:29:26,920 --> 00:29:27,320
+intention
+
+420
+00:29:30,810 --> 00:29:34,010
+even but it's a mistake as usual when we say a
+
+421
+00:29:34,010 --> 00:29:36,770
+mistake it's not by intention if it's by intention
+
+422
+00:29:36,770 --> 00:29:41,370
+it becomes it becomes a fraud deception it's not a
+
+423
+00:29:41,370 --> 00:29:44,490
+mistake then a mistake one like you know anyone
+
+424
+00:29:44,490 --> 00:29:46,770
+can make a mistake in life then as i said before
+
+425
+00:29:46,770 --> 00:29:49,770
+at the beginning that we have to uphold we have to
+
+426
+00:29:49,770 --> 00:29:52,790
+support we have to keep the contract if it's a
+
+427
+00:29:52,790 --> 00:29:56,750
+deception if it's deception thenidentity mistake
+
+428
+00:29:56,750 --> 00:29:59,650
+seems to me like it's on purpose No it's not it
+
+429
+00:29:59,650 --> 00:30:01,570
+can be sometimes by mistake it does happen by
+
+430
+00:30:01,570 --> 00:30:04,430
+mistake like you know the contract itself was not
+
+431
+00:30:04,430 --> 00:30:08,450
+so clear I mistaken on one party like I assume a
+
+432
+00:30:08,450 --> 00:30:13,590
+situation like I assume that my company my company
+
+433
+00:30:13,590 --> 00:30:17,650
+employing females only then I want someone else to
+
+434
+00:30:17,650 --> 00:30:22,420
+work in my company thenI would assume other
+
+435
+00:30:22,420 --> 00:30:25,240
+companies would .. would understand my situation
+
+436
+00:30:25,240 --> 00:30:27,880
+like for example at the Islamic university here we
+
+437
+00:30:27,880 --> 00:30:31,640
+have male classes and female classes isn't it؟ we
+
+438
+00:30:31,640 --> 00:30:35,100
+do not mix in this case .. in this case here when
+
+439
+00:30:35,100 --> 00:30:39,980
+we employ a female to work as a cleaner where she
+
+440
+00:30:39,980 --> 00:30:43,040
+gonna be working? in the female section I can
+
+441
+00:30:43,040 --> 00:30:45,300
+assume this I cannot say well I want a male
+
+442
+00:30:45,300 --> 00:30:51,070
+cleanerand to work in the female section with them
+
+443
+00:30:51,070 --> 00:30:53,410
+it's not like we can assume situations sometimes
+
+444
+00:30:53,410 --> 00:31:01,970
+we have an identity to match the situation second
+
+445
+00:31:01,970 --> 00:31:05,550
+type of mistake it's a mutual mistake a mutual
+
+446
+00:31:05,550 --> 00:31:09,550
+mistake a
+
+447
+00:31:09,550 --> 00:31:12,510
+mutual it can be done by both a mutual what does
+
+448
+00:31:12,510 --> 00:31:19,480
+it mean by bothit's done by both part .. both of
+
+449
+00:31:19,480 --> 00:31:23,300
+them has making the same mistake they want to read
+
+450
+00:31:23,300 --> 00:31:27,020
+it for me mutual mistake both parties of a
+
+451
+00:31:27,020 --> 00:31:31,060
+contract are mistaken as the terms each believes
+
+452
+00:31:31,060 --> 00:31:34,600
+they are contracting to something different both
+
+453
+00:31:34,600 --> 00:31:36,580
+of them have making the same mistake believing
+
+454
+00:31:36,580 --> 00:31:40,780
+that they have contract to something else whether
+
+455
+00:31:40,780 --> 00:31:42,900
+gonna be the same situation as we have at the
+
+456
+00:31:42,900 --> 00:31:47,430
+beginningالخطأ المعين أو المخطط المتعامل هو نفس
+
+457
+00:31:47,430 --> 00:31:53,570
+النتائج انها خطأ وليس مخاطرة وليس بالهدف يجب أن
+
+458
+00:31:53,570 --> 00:31:58,630
+نساعد كلا الحكومات لتحفظ التطبيق يجب أن نحافظ على
+
+459
+00:31:58,630 --> 00:32:04,120
+هذا التطبيق لأننا لا نريد أن نتعاملWe don't want
+
+460
+00:32:04,120 --> 00:32:07,340
+to impede business in the market. We want to help
+
+461
+00:32:07,340 --> 00:32:11,260
+merchants to complete their own business. Then the
+
+462
+00:32:11,260 --> 00:32:15,600
+court usually tries to uphold such a contract if
+
+463
+00:32:15,600 --> 00:32:21,620
+reasonable interpretation can be foundنستطيع أن
+
+464
+00:32:21,620 --> 00:32:26,000
+نجد مجتمع معين نستطيع أن نجد مقاومة بين الانتصارين
+
+465
+00:32:26,000 --> 00:32:31,400
+نستطيع أن نجد فهم مفهوم بينهم بعد ذلك يستطيعوا أن
+
+466
+00:32:31,400 --> 00:32:36,840
+يجلسوا مع بعض مع رحل مع مدير و يستطيعوا أن يصنعوا
+
+467
+00:32:36,840 --> 00:32:41,320
+عقلهم نفسهم يستطيعوا أن يقبلوا هذه الخطأ كيف
+
+468
+00:32:41,320 --> 00:32:46,300
+تتعامل مع كل حاجة حسنًا لكننا لا نستطيع أن نقول
+
+469
+00:32:46,300 --> 00:32:49,900
+مثلفي هذه الحالة هنا إذا قمنا بإختيار متسلل متسلل
+
+470
+00:32:49,900 --> 00:32:54,340
+مثلما كان لدينا في السlide الأخير يمكننا أن نكون
+
+471
+00:32:54,340 --> 00:32:57,800
+في بعض الأحيان متسللين في القدرات القدرات أو
+
+472
+00:32:57,800 --> 00:33:02,140
+القدرات هي شيء غير مفهوم غير مفهوم، لكن في بعض
+
+473
+00:33:02,140 --> 00:33:07,360
+الأحيان يكون لديهم مفهوم مفهوم، شيء غير مفهومإذا
+
+474
+00:33:07,360 --> 00:33:11,840
+كان لدينا قرار، قرار مخطط، مثلا انا اقرر حالة مثلا
+
+475
+00:33:11,840 --> 00:33:16,800
+اقرر ان الكاميرا تعمل ولكنها لا تعمل ربما، مثلا
+
+476
+00:33:16,800 --> 00:33:26,920
+اقرر هنا اي حالة، اي حالة، اقرر اننا شتنا نصف طن
+
+477
+00:33:26,920 --> 00:33:35,200
+من الذنب، نصف طن من الذنب منولكن هذا الجلد يحتوي
+
+478
+00:33:35,200 --> 00:33:42,300
+على طرق مختلفة،
+
+479
+00:33:42,300 --> 00:33:46,800
+فهو ليس نفس الشيء، يعني كل نوع من الجلد يتسبب في
+
+480
+00:33:46,800 --> 00:33:53,140
+عدد مختلف من المال، بسكيل مختلف، بسكيل مختلف، فأنا
+
+481
+00:33:53,140 --> 00:33:58,540
+أحيانًا أستطيع أن أعمل قرار عن نفسي، ولكن قراري لا
+
+482
+00:33:58,540 --> 00:34:02,590
+يمكن أن يكون حقيقة حقيقية، إنها ليست حقيقةI can
+
+483
+00:34:02,590 --> 00:34:05,310
+make a mistake in the judgment and this mistake in
+
+484
+00:34:05,310 --> 00:34:09,870
+judgment can .. can it be considered as a mistake؟
+
+485
+00:34:09,870 --> 00:34:14,410
+yes yes well okay if somebody makes a mistake in
+
+486
+00:34:14,410 --> 00:34:17,570
+judgment can we cancel the contract for this
+
+487
+00:34:17,570 --> 00:34:21,170
+reason؟ can we؟ it depends on its consequences
+
+488
+00:34:21,170 --> 00:34:24,850
+whether
+
+489
+00:34:24,850 --> 00:34:30,600
+they were feasible sensible subjectOkay, let's see
+
+490
+00:34:30,600 --> 00:34:33,640
+the solution for this. Can you read it? Go on. I
+
+491
+00:34:33,640 --> 00:34:38,520
+don't want to .. Speak up. A contract based on a
+
+492
+00:34:38,520 --> 00:34:44,340
+mutual mistake and judgment is not voidable by the
+
+493
+00:34:44,340 --> 00:34:47,920
+party that is adversely affected It's not. It
+
+494
+00:34:47,920 --> 00:34:50,240
+cannot void it. A judgment, it's not something
+
+495
+00:34:50,240 --> 00:34:54,950
+feasible. I judge a situation herelike assuming my
+
+496
+00:34:54,950 --> 00:34:58,890
+opinion was right just my opinion assuming the
+
+497
+00:34:58,890 --> 00:35:02,030
+result would be better but it's not we cannot
+
+498
+00:35:02,030 --> 00:35:05,810
+build sometimes we cannot build we cannot build
+
+499
+00:35:05,810 --> 00:35:10,370
+evidence on just opinion we have to build it on
+
+500
+00:35:10,370 --> 00:35:14,330
+fact I cannot take what you think in your mind as
+
+501
+00:35:14,330 --> 00:35:17,090
+a fact it might be a fact it might be materialized
+
+502
+00:35:17,090 --> 00:35:21,170
+as a fact but it might be notit depends on each
+
+503
+00:35:21,170 --> 00:35:25,630
+case like I can analyze any situation as economic
+
+504
+00:35:25,630 --> 00:35:30,230
+analyst or as business analyst I can analyze a
+
+505
+00:35:30,230 --> 00:35:34,250
+business situation but my analysis can be true
+
+506
+00:35:34,250 --> 00:35:40,570
+fact can be false it's just analysis judgment the
+
+507
+00:35:40,570 --> 00:35:45,530
+last type is common mistake common common mistake
+
+508
+00:35:45,530 --> 00:35:50,170
+a mistake can be made by anyoneفي نفس الوضع مثلما
+
+509
+00:35:50,170 --> 00:35:55,090
+أقف هنا و أخطأ اليوم و أي شخص آخر في مكاني يفعل
+
+510
+00:35:55,090 --> 00:36:01,070
+نفس الخطأ أي شخص، إنه خطأ عام نحن لدينا الكثير من
+
+511
+00:36:01,070 --> 00:36:05,390
+الأشياء مثل هذه في حياتنا خطأ
+
+512
+00:36:05,390 --> 00:36:10,230
+عام، كلا الشركات تحتفظ بالخطأ و تؤمن بالفعل كلا
+
+513
+00:36:10,230 --> 00:36:15,470
+الشركات تؤمن بأن هذا هو الحقيقة ولكنه ليس كذلك و
+
+514
+00:36:15,470 --> 00:36:20,250
+هذا حدث أكتر ممكن بين مرشدينin Gaza and merchants
+
+515
+00:36:20,250 --> 00:36:25,010
+in Egypt importing goods through tunnels those
+
+516
+00:36:25,010 --> 00:36:28,650
+goods they get them here merchants in Gaza and
+
+517
+00:36:28,650 --> 00:36:30,650
+merchants in Egypt both of them making the same
+
+518
+00:36:30,650 --> 00:36:34,390
+mistake believing the items we have imported would
+
+519
+00:36:34,390 --> 00:36:38,070
+be suitable for such buildings would be suitable
+
+520
+00:36:38,070 --> 00:36:42,710
+like for example as I said the paint the glass the
+
+521
+00:36:42,710 --> 00:36:48,990
+cement the iron the stones when you buy themboth
+
+522
+00:36:48,990 --> 00:36:53,150
+parties believe this .. this equality is the
+
+523
+00:36:53,150 --> 00:36:55,130
+equality wanted but in fact anyone in this
+
+524
+00:36:55,130 --> 00:36:58,350
+situation would make the same mistake ف it's not
+
+525
+00:36:58,350 --> 00:37:00,530
+the equality really wanted in a .. in a normal
+
+526
+00:37:00,530 --> 00:37:05,110
+situationit's not and people use it it's fine it
+
+527
+00:37:05,110 --> 00:37:08,490
+becomes something normal like هو الخطأ الشائعة خطأ
+
+528
+00:37:08,490 --> 00:37:11,490
+الشائعة many many of us making mistake in our life
+
+529
+00:37:11,490 --> 00:37:14,430
+believing that this is fine this is okay why
+
+530
+00:37:14,430 --> 00:37:16,570
+because everyone is making the same thing in a
+
+531
+00:37:16,570 --> 00:37:19,410
+society but this does not make it right it's not
+
+532
+00:37:19,410 --> 00:37:22,370
+true it's not it's a mistake it's still a mistake
+
+533
+00:37:22,370 --> 00:37:25,110
+so in this case because everybody's making the
+
+534
+00:37:25,110 --> 00:37:28,330
+same mistake in the same society then it's fine we
+
+535
+00:37:28,330 --> 00:37:34,240
+just you know close an eyedo not locate it leave
+
+536
+00:37:34,240 --> 00:37:38,300
+it this will not affect the contract common
+
+537
+00:37:38,300 --> 00:37:42,140
+mistake is will not affect the contract unless
+
+538
+00:37:42,140 --> 00:37:48,120
+unless what go
+
+539
+00:37:48,120 --> 00:37:48,900
+on read it
+
+540
+00:38:10,230 --> 00:38:14,530
+Okay in one case only we can avoid this contract
+
+541
+00:38:14,530 --> 00:38:18,900
+mostlyمثلًا إذا كان هناك خطأ عام، خطأ يمكن أن يكون
+
+542
+00:38:18,900 --> 00:38:22,220
+فعله أحدهم في المجتمع أو أحدهم في هذه الحالة، فهو
+
+543
+00:38:22,220 --> 00:38:25,440
+بخير، اتركه فقط، ليس خطأ، لأن أحدهم يستطيع أن
+
+544
+00:38:25,440 --> 00:38:32,820
+يفعلها إلا إذا كان لدينا خطأ أساسي هنا، خطأ أساسي،
+
+545
+00:38:32,820 --> 00:38:36,100
+أعني كان أساسياً لتحويل إدارتها إلى شخصية مختلفة،
+
+546
+00:38:36,100 --> 00:38:42,500
+كان أساسياً، كان أهم، كان مهم، هذا أثرت على
+
+547
+00:38:42,500 --> 00:38:47,160
+التعامل في حالة سيئةإذا كانت هذه الخطأ تأثير على
+
+548
+00:38:47,160 --> 00:38:51,820
+المشروع في حالة سيئة جدًا في الواقع الواقع الواقع
+
+549
+00:38:51,820 --> 00:38:53,640
+الواقع الواقع الواقع الواقع الواقع الواقع الواقع
+
+550
+00:38:53,640 --> 00:38:54,320
+الواقع الواقع الواقع الواقع الواقع الواقع الواقع
+
+551
+00:38:54,320 --> 00:38:57,020
+الواقع الواقع الواقع الواقع الواقع الواقع الواقع
+
+552
+00:38:57,020 --> 00:38:57,360
+الواقع الواقع الواقع الواقع الواقع الواقع الواقع
+
+553
+00:38:57,360 --> 00:39:00,440
+الواقع الواقع الواقع الواقع الواقع الواقع الواقع
+
+554
+00:39:00,440 --> 00:39:14,280
+الواقع الواقع الواقع الوا
+
+555
+00:39:15,440 --> 00:39:18,320
+when you import them in building the construction
+
+556
+00:39:18,320 --> 00:39:22,180
+itself you have different styles of building and
+
+557
+00:39:22,180 --> 00:39:26,860
+they need specific materials and especially if you
+
+558
+00:39:26,860 --> 00:39:31,800
+would like to build something .. something which
+
+559
+00:39:31,800 --> 00:39:35,980
+can be used as a lab laboratory you need a cement
+
+560
+00:39:35,980 --> 00:39:41,560
+a specific cement quality an ion in a special
+
+561
+00:39:41,560 --> 00:39:46,350
+paintكل شيء يجب أن يكون بالنسبة للقوة. الناس اللي
+
+562
+00:39:46,350 --> 00:39:50,410
+اشتروا السمنة من مصر، كانوا يحصلوا على 50 طن لبنة
+
+563
+00:39:50,410 --> 00:39:57,230
+مثلها، 50 طن من السمنة اشتروا لبنة مثلها، السمنة
+
+564
+00:39:57,230 --> 00:40:02,000
+كشخص يشترها من مصر كل وقت، يبنوا منزلهمit looks to
+
+565
+00:40:02,000 --> 00:40:05,360
+anyone it's fine it's not the same quality this
+
+566
+00:40:05,360 --> 00:40:09,280
+cement comes from Egypt comes from Turkey comes
+
+567
+00:40:09,280 --> 00:40:12,840
+from China it's not the same quality it's not the
+
+568
+00:40:12,840 --> 00:40:16,180
+same level then you can use it sometimes people
+
+569
+00:40:16,180 --> 00:40:20,280
+what they do they just increase the amount can
+
+570
+00:40:20,280 --> 00:40:24,800
+increase the amount of cement to compensate the
+
+571
+00:40:24,800 --> 00:40:27,580
+lack of quality because the quality is not good
+
+572
+00:40:27,580 --> 00:40:31,140
+sometimes the sugar it's not sweet enoughماذا
+
+573
+00:40:31,140 --> 00:40:34,300
+يمكنك أن تفعل؟ بدل من أن تحصل على سمك واحد، يمكنك
+
+574
+00:40:34,300 --> 00:40:37,140
+أن تحصل على إثنين سمك من السمك. فقط عليك أن تقوم
+
+575
+00:40:37,140 --> 00:40:40,000
+بإيقافه. إنه مثل السمك البرون والسمك البيضاء. هل
+
+576
+00:40:40,000 --> 00:40:44,440
+هو نفس الشيء؟ ليس كذلك. أي شيء بيتر؟ السمك البرون.
+
+577
+00:40:45,580 --> 00:40:49,920
+إنه بيتر. إنه ليس لذلك حلو كالسمك البيضاء. إنه
+
+578
+00:40:49,920 --> 00:40:54,240
+أكثر صحي. على أية حال، بدون السمك بيتر على أية
+
+579
+00:40:54,240 --> 00:40:58,460
+حال. إذا لم تستخدمه، فهو أكتر بيتر. كل شيء مظلم.
+
+580
+00:40:59,730 --> 00:41:02,430
+it's more healthy anyway so the quality sometimes
+
+581
+00:41:02,430 --> 00:41:04,490
+you have to compensate the quality by increasing
+
+582
+00:41:04,490 --> 00:41:09,970
+the amount if the quality you wanted even if it
+
+583
+00:41:09,970 --> 00:41:12,470
+was a mistake because people here most people in
+
+584
+00:41:12,470 --> 00:41:15,770
+our society most of them don't know the difference
+
+585
+00:41:15,770 --> 00:41:18,810
+between brown or white sugar believe it or not
+
+586
+00:41:18,810 --> 00:41:23,210
+most of them they have no idea okay not not only
+
+587
+00:41:23,210 --> 00:41:26,290
+sugar and many things in our life even they don't
+
+588
+00:41:26,290 --> 00:41:30,520
+have much of the tasteit's a common mistake or
+
+589
+00:41:30,520 --> 00:41:33,440
+it's fine it's accepted they don't know you buy
+
+590
+00:41:33,440 --> 00:41:36,180
+buy 10 kilos of white sugar and 10 kilos of brown
+
+591
+00:41:36,180 --> 00:41:39,400
+sugar not the same equality not the same sweetness
+
+592
+00:41:39,400 --> 00:41:44,020
+but people still think it's the same it's a common
+
+593
+00:41:44,020 --> 00:41:48,580
+mistake but sometimes if this would affect would
+
+594
+00:41:48,580 --> 00:41:51,180
+affect the contract the subject matter because if
+
+595
+00:41:51,180 --> 00:41:56,510
+we need this sugar to manufacture biscuitsو هذه
+
+596
+00:41:56,510 --> 00:42:01,950
+اللوحات ستحتاج إلى عدد محدد من الضغط ونوع محدد إذا
+
+597
+00:42:01,950 --> 00:42:09,150
+كانت مشكلتها عامة و هذا يكون أساسيا لتخلق يؤدي
+
+598
+00:42:09,150 --> 00:42:15,850
+اعتبارها مختلفا عن ما كان مقرره فهذا المقرر سيكون
+
+599
+00:42:15,850 --> 00:42:19,790
+غير صحيح يمكن أن يكون غير صحيح انتقاله إلى الجمهور
+
+600
+00:42:22,500 --> 00:42:24,420
+هو would get the benefit out of this، he can
+
+601
+00:42:24,420 --> 00:42:27,120
+invalidate it، you have many examples in our life،
+
+602
+00:42:27,120 --> 00:42:29,440
+I cannot have things all the time in my mind
+
+603
+00:42:29,440 --> 00:42:33,060
+because if you go to the market، you will witness
+
+604
+00:42:33,060 --> 00:42:37,280
+lots of things, lots of cases، look for example
+
+605
+00:42:37,280 --> 00:42:40,700
+the crisp، when you buy the crisp، many people
+
+606
+00:42:40,700 --> 00:42:43,600
+buying the crisp، many types of the crisp، made in
+
+607
+00:42:43,600 --> 00:42:45,920
+Egypt، made in Turkey، made in many other
+
+608
+00:42:45,920 --> 00:42:48,320
+countries، bringing them to Gaza to sell them here
+
+609
+00:42:49,710 --> 00:42:54,890
+no okay leave it give another case buying soap
+
+610
+00:42:54,890 --> 00:42:59,630
+سابونة شامبون many type the same و the same name
+
+611
+00:42:59,630 --> 00:43:02,770
+the same but have different brands different
+
+612
+00:43:02,770 --> 00:43:06,970
+companies manufacturing it different countries not
+
+613
+00:43:06,970 --> 00:43:10,070
+the same quality like having the head and shoulder
+
+614
+00:43:10,070 --> 00:43:14,490
+few month ago from turkey and it costing only
+
+615
+00:43:14,490 --> 00:43:17,430
+seven eight shekels and in the market it cost
+
+616
+00:43:17,430 --> 00:43:19,780
+twenty shekels or eighteen shekelsit's not the
+
+617
+00:43:19,780 --> 00:43:24,240
+same equality then if we have a common mistake it
+
+618
+00:43:24,240 --> 00:43:26,700
+can be accepted by all people it's fine but
+
+619
+00:43:26,700 --> 00:43:32,520
+sometimes you need a specific item in this case if
+
+620
+00:43:32,520 --> 00:43:35,600
+we have a mistake even if it's common mistake we
+
+621
+00:43:35,600 --> 00:43:36,820
+can cancel the contract
+
+622
+00:43:39,590 --> 00:43:41,690
+it depends on our situation here it depends on the
+
+623
+00:43:41,690 --> 00:43:45,410
+case what we have what we need the item for what
+
+624
+00:43:45,410 --> 00:43:47,910
+the consequences would be how much would it cost
+
+625
+00:43:47,910 --> 00:43:50,950
+we have many factors would affect each contract
+
+626
+00:43:50,950 --> 00:43:57,590
+okay do you get what I'm saying yes yes good now
+
+627
+00:43:57,590 --> 00:44:00,150
+it's gonna be easy this slide much easier what we
+
+628
+00:44:00,150 --> 00:44:03,410
+have we have two situations one of them it's
+
+629
+00:44:03,410 --> 00:44:08,330
+called duress and the second it's called undue
+
+630
+00:44:08,330 --> 00:44:13,350
+influenceduress it's not the same they look like
+
+631
+00:44:13,350 --> 00:44:16,950
+the same for some people they mix between them but
+
+632
+00:44:16,950 --> 00:44:20,590
+they're not completely they're not duress is
+
+633
+00:44:20,590 --> 00:44:26,610
+threat of harm and this is a feasible situation
+
+634
+00:44:26,610 --> 00:44:31,970
+realistic situation happens in some cases somebody
+
+635
+00:44:31,970 --> 00:44:36,290
+can really go on what's your name Dalia okay Dalia
+
+636
+00:44:40,690 --> 00:44:46,770
+one person to compel another to do something
+
+637
+00:44:46,770 --> 00:44:52,650
+against his will or judgment through a transaction
+
+638
+00:44:52,650 --> 00:44:55,710
+without real assent simple case .. simple
+
+639
+00:44:55,710 --> 00:45:02,070
+situation one a would make a threat of harm to b
+
+640
+00:45:02,070 --> 00:45:05,610
+to make a contract otherwise if he does not make
+
+641
+00:45:05,610 --> 00:45:11,440
+it then he would fulfill his threathe would take
+
+642
+00:45:11,440 --> 00:45:16,740
+an action like we have a case here Mr Barton and
+
+643
+00:45:16,740 --> 00:45:22,100
+Mr Armstrong Armstrong threatened to kill Barton
+
+644
+00:45:22,100 --> 00:45:27,200
+if he does not sign the contract if you don't sign
+
+645
+00:45:27,200 --> 00:45:30,840
+the contract you will be dead this is gonna be the
+
+646
+00:45:30,840 --> 00:45:33,720
+last day of your life then are you gonna sign it
+
+647
+00:45:33,720 --> 00:45:37,580
+or not most likely not everybody you gonna sign it
+
+648
+00:45:37,580 --> 00:45:43,990
+are youاه you gonna keep your life some people
+
+649
+00:45:43,990 --> 00:45:47,810
+don't know they just spend their life getting
+
+650
+00:45:47,810 --> 00:45:50,370
+money making business and then they gonna lose
+
+651
+00:45:50,370 --> 00:45:53,990
+their life in a few minutes time acting in a fool
+
+652
+00:45:53,990 --> 00:45:59,990
+way but here that if someone signed a contract
+
+653
+00:45:59,990 --> 00:46:02,390
+under the threats what do you think the situation
+
+654
+00:46:02,390 --> 00:46:07,370
+will be the consequences invalid is it why is it
+
+655
+00:46:08,560 --> 00:46:11,180
+انت قمت بإشتراكه بس .. انت قمت بإشتراكه .. هيا ..
+
+656
+00:46:11,180 --> 00:46:15,300
+انت قمت بإشتراك مجلد معي .. لكن انت قمت بإشتراكه
+
+657
+00:46:15,300 --> 00:46:19,480
+لأنني مخاطر .. أنا مخاطر أن أقتلك إذا لم تشتره ..
+
+658
+00:46:19,480 --> 00:46:23,100
+ثم قمت بإشتراكه .. أنا أعطيك المال .. انت تعلم ..
+
+659
+00:46:23,100 --> 00:46:26,360
+أنا حصلت على سيارتك .. أنا لدي سيارتك .. و أنا
+
+660
+00:46:26,360 --> 00:46:30,320
+أعطيك المال .. كم أنت طلبته .. كم أنه متساوي في
+
+661
+00:46:30,320 --> 00:46:33,640
+السوق .. بالضبط .. لكنك لم تريد أن تشتره .. لكني
+
+662
+00:46:33,640 --> 00:46:39,030
+قلت .. إذا لم تشتر السيارة .. أنا سأخطرك ..either
+
+663
+00:46:39,030 --> 00:46:42,050
+you gonna sell it or not if you do then this
+
+664
+00:46:42,050 --> 00:46:47,150
+contract will be invalid contract as it does not
+
+665
+00:46:47,150 --> 00:46:52,110
+exist but you have to prove this case why why does
+
+666
+00:46:52,110 --> 00:46:58,470
+it exist why it does not exist this contract as
+
+667
+00:46:58,470 --> 00:47:02,250
+it's it's invalidated why because we missed
+
+668
+00:47:02,250 --> 00:47:06,650
+important situation which is
+
+669
+00:47:09,280 --> 00:47:12,420
+إنك قمت بإشتراك التطبيق و قمت بإشتراك التطبيق و
+
+670
+00:47:12,420 --> 00:47:16,560
+قمت بإشتراك التطبيق و قمت بإشتراك التطبيق و قمت
+
+671
+00:47:16,560 --> 00:47:17,480
+بإشتراك التطبيق و قمت بإشتراك التطبيق و قمت
+
+672
+00:47:17,480 --> 00:47:18,720
+بإشتراك التطبيق و قمت بإشتراك التطبيق و قمت
+
+673
+00:47:18,720 --> 00:47:19,660
+بإشتراك التطبيق و قمت بإشتراك التطبيق و قمت
+
+674
+00:47:19,660 --> 00:47:20,840
+بإشتراك التطبيق و قمت بإشتراك التطبيق و قمت
+
+675
+00:47:20,840 --> 00:47:24,480
+بإشتراك التطبيق و قمت بإشتراك التطبيق و قمت
+
+676
+00:47:24,480 --> 00:47:30,000
+بإشتراك
+
+677
+00:47:30,000 --> 00:47:34,080
+التطبيق و
+
+678
+00:47:34,080 --> 00:47:39,870
+قمت بإشتراك التطالان في هذه الحالة، المشكلة هي كيف
+
+679
+00:47:39,870 --> 00:47:44,850
+أثبتها، كيف أقوم بإيقاف الحجارة أنني قمت بالقرار
+
+680
+00:47:44,850 --> 00:47:53,170
+ولكني قمت بإقامته تحت ضغط؟ ربما او
+
+681
+00:47:53,170 --> 00:47:55,890
+هيا أنا سأقول، هيا، هيا، هل يمكنك أن تنتظر قليل من
+
+682
+00:47:55,890 --> 00:48:01,160
+الوقت؟ سأقوم بإقامتهit doesn't have it like this
+
+683
+00:48:01,160 --> 00:48:03,660
+.. it's not .. sometimes you miss the chance ..
+
+684
+00:48:03,660 --> 00:48:07,100
+you cannot prove it .. sometimes you can .. you
+
+685
+00:48:07,100 --> 00:48:11,280
+can have a witness .. you can have it recorded ..
+
+686
+00:48:11,280 --> 00:48:13,820
+you can have it by implications .. like by
+
+687
+00:48:13,820 --> 00:48:18,020
+indicationsماذا يعني بإشارات؟ ليس بسهولة في هذه
+
+688
+00:48:18,020 --> 00:48:21,680
+الحالة انا أستطيع أن أثبت أن هذه المنزل كانت مليئة
+
+689
+00:48:21,680 --> 00:48:25,420
+بيها أنا لم أرغب بأن أسحبها لأنني كنت تهتم تهتم
+
+690
+00:48:25,420 --> 00:48:27,840
+تهتم تهتم تهتم تهتم تهتم تهتم تهتم تهتم تهتم تهتم
+
+691
+00:48:27,840 --> 00:48:28,040
+تهتم تهتم تهتم تهتم تهتم تهتم تهتم تهتم تهتم تهتم
+
+692
+00:48:28,040 --> 00:48:28,560
+تهتم تهتم تهتم تهتم تهتم تهتم تهتم تهتم تهتم تهتم
+
+693
+00:48:28,560 --> 00:48:32,160
+تهتم تهتم تهتم
+
+694
+00:48:32,160 --> 00:48:39,200
+تهتم تهتم تهتم تهتم
+
+695
+00:48:39,200 --> 00:48:42,660
+تhe made some statements that he wants this house
+
+696
+00:48:42,660 --> 00:48:45,440
+he made some statements and people witnessed this
+
+697
+00:48:45,440 --> 00:48:48,340
+but at this minute specific minute when i signed
+
+698
+00:48:48,340 --> 00:48:51,520
+the contract with him i had no witness but i can
+
+699
+00:48:51,520 --> 00:48:55,220
+prove it by and even the money the cost the amount
+
+700
+00:48:55,220 --> 00:49:01,240
+how much it cost some time it
+
+701
+00:49:01,240 --> 00:49:05,440
+can be taken into consideration because no one
+
+702
+00:49:05,440 --> 00:49:07,120
+like you know if you don't want to sell your house
+
+703
+00:49:07,120 --> 00:49:10,780
+why did you sell it come onإذا كان لدي مصطلح في
+
+704
+00:49:10,780 --> 00:49:14,980
+الحكومة يقول إن هذا منزلي و أقوم ببناءه لأنني كنت
+
+705
+00:49:14,980 --> 00:49:19,700
+في تهيأم أنا كنت في تهيأم الآن أريد أن أعود إليه
+
+706
+00:49:19,700 --> 00:49:24,300
+إذا لم أكن في تهيأم منذ البداية لماذا أقوم ببناءه
+
+707
+00:49:24,300 --> 00:49:29,400
+على أي حال؟ نحن لدينا بعض الانتجارات أن الحكم ليس
+
+708
+00:49:29,400 --> 00:49:34,200
+غبي هو أو هي سوف ينظر جهدا إلى الحكومة وسوف تحضر
+
+709
+00:49:34,200 --> 00:49:38,180
+معروفات كثيرة وسوف يتأكد .. سيجب أن يتأكد أن هذا
+
+710
+00:49:38,180 --> 00:49:43,080
+الحكومةهذا الحدث هو حد حقيقي مثلًا هذا الرجل يجب
+
+711
+00:49:43,080 --> 00:49:47,680
+أن يثبت وهو مسؤولتك إذا كنت في تهديد هنا فجهة
+
+712
+00:49:47,680 --> 00:49:52,260
+مخاطرة يجب أن تثبت انها مسؤولتك ليست القاضي اللي
+
+713
+00:49:52,260 --> 00:49:55,440
+يستطيع أن يبحث عن الوثيقة انت فعلا يجب أن تبحث عن
+
+714
+00:49:55,440 --> 00:50:02,760
+وثيقة هنا لتثبتالهجوم كان صنعه وكانت السبب لدخوله
+
+715
+00:50:02,760 --> 00:50:06,760
+إلى التطبيق هو الهجوم الذي يجعلك تذهب و تشترك في
+
+716
+00:50:06,760 --> 00:50:13,360
+هذا التطبيق إلا أنك لن تشترك فيه الآن إذا A كان
+
+717
+00:50:13,360 --> 00:50:18,920
+لديه أثبات أنه كان تحت ضغط وشترك في التطبيق لأنه
+
+718
+00:50:18,920 --> 00:50:24,980
+كان .. كان سيقتل أو يتحرك من الجانب الثاني ثم
+
+719
+00:50:24,980 --> 00:50:30,790
+الجانب الثانييمكنها أن تثبت المقابل كل واحد منهم
+
+720
+00:50:30,790 --> 00:50:33,410
+يجب أن يحضر الوثيقة انا أستطيع أن أحضر الوثيقة
+
+721
+00:50:33,410 --> 00:50:36,250
+وانه او انها يستطيعون أن تحضر الوثيقة اللي هي
+
+722
+00:50:36,250 --> 00:50:39,370
+الوثيقة القوية اللي يستطيع الحجر أن يأخذها مثلا
+
+723
+00:50:39,370 --> 00:50:43,650
+يقولوا بأن الجمهور يستطيع أن يحضر الوثيقة الواقعي
+
+724
+00:50:43,650 --> 00:50:46,130
+يستطيع أن يحضر الوثيقة الواقعي يستطيع أن يحضر
+
+725
+00:50:46,130 --> 00:50:46,390
+الوثيقة الواقعي يستطيع أن يحضر الوثيقة الواقعي
+
+726
+00:50:46,390 --> 00:50:49,970
+يستطيع أن يحضر الوثيقة الواقعي يستطيع أن يحضر
+
+727
+00:50:49,970 --> 00:50:53,070
+الوثيقة الواقعي يستطيع
+
+728
+00:50:57,600 --> 00:51:01,460
+second party if I prove that I signed a contract
+
+729
+00:51:01,460 --> 00:51:06,080
+under threat I did and the judge believe me then
+
+730
+00:51:06,080 --> 00:51:10,800
+the second party can prove the opposite later on
+
+731
+00:51:10,800 --> 00:51:16,500
+and the ownership of a proof shifts from me to him
+
+732
+00:51:16,500 --> 00:51:21,360
+he can prove that okay well I threatened him I
+
+733
+00:51:21,360 --> 00:51:26,070
+threatened himof harm but he did not sign the
+
+734
+00:51:26,070 --> 00:51:28,970
+contract because of this he signed the contract at
+
+735
+00:51:28,970 --> 00:51:31,290
+the time when he signed the contract he has the
+
+736
+00:51:31,290 --> 00:51:34,010
+full intention he wanted to sell me the house or
+
+737
+00:51:34,010 --> 00:51:38,210
+the car I did not I did not force that person to
+
+738
+00:51:38,210 --> 00:51:42,770
+sell he has the full intention to do so now this
+
+739
+00:51:42,770 --> 00:51:48,970
+is a very unique case sometimes can bebecause this
+
+740
+00:51:48,970 --> 00:51:52,370
+.. this can happen in our life but this can be
+
+741
+00:51:52,370 --> 00:51:55,590
+difficult to prove unless if you have witnesses
+
+742
+00:51:55,590 --> 00:51:59,610
+and we come into an area which is really difficult
+
+743
+00:51:59,610 --> 00:52:02,890
+looking at intention it's something exists inside
+
+744
+00:52:02,890 --> 00:52:05,970
+ourselves I cannot know my own .. your intention
+
+745
+00:52:05,970 --> 00:52:09,570
+unless I have some indications like I know today
+
+746
+00:52:09,570 --> 00:52:12,390
+like you have the intention to attend the class
+
+747
+00:52:12,390 --> 00:52:17,190
+because you love to studyI can assume this you
+
+748
+00:52:17,190 --> 00:52:19,710
+attend the class because you love to study
+
+749
+00:52:19,710 --> 00:52:23,210
+commercial law it's a nice subject it's amazing
+
+750
+00:52:23,210 --> 00:52:29,310
+assuming this unless you prove something else if
+
+751
+00:52:29,310 --> 00:52:31,390
+you don't attend the class I can understand
+
+752
+00:52:31,390 --> 00:52:35,490
+because I can see all of you in the class trying
+
+753
+00:52:35,490 --> 00:52:38,310
+to answer a question you are awake looking at me
+
+754
+00:52:38,310 --> 00:52:43,280
+at the slides you are doing wellunless you have
+
+755
+00:52:43,280 --> 00:52:45,560
+something else in your mind so I can know the
+
+756
+00:52:45,560 --> 00:52:48,800
+intention by some indications you might not like
+
+757
+00:52:48,800 --> 00:52:54,640
+the class or the subject or me which is fine but
+
+758
+00:52:54,640 --> 00:53:00,700
+then it's
+
+759
+00:53:00,700 --> 00:53:03,380
+something inside a human being the intention
+
+760
+00:53:03,380 --> 00:53:07,700
+something exists inside you I cannot easily
+
+761
+00:53:09,460 --> 00:53:12,260
+understand what's inside every human being without
+
+762
+00:53:12,260 --> 00:53:15,460
+looking at the indications now we're gonna go to
+
+763
+00:53:15,460 --> 00:53:19,160
+the next slide which some somehow looks like this
+
+764
+00:53:19,160 --> 00:53:26,640
+somehow it's the un here undue influence it's not
+
+765
+00:53:26,640 --> 00:53:31,560
+a juris a juris هو التهديد threat undue influence
+
+766
+00:53:31,560 --> 00:53:38,840
+influenceeffect تأثير but it's undue فيش توازن
+
+767
+00:53:38,840 --> 00:53:44,580
+undue influence two parties a and b having undue
+
+768
+00:53:44,580 --> 00:53:48,040
+influence one of them is strong and the second is
+
+769
+00:53:48,040 --> 00:53:54,100
+weak no balance like the like if we look in
+
+770
+00:53:54,100 --> 00:53:57,220
+politics for example negotiations between Israel
+
+771
+00:53:57,220 --> 00:53:59,900
+and the Palestinian authority strong and weak
+
+772
+00:53:59,900 --> 00:54:04,420
+there is no balance of powerالنفس الشيء .. هذا
+
+773
+00:54:04,420 --> 00:54:07,600
+اتفاق .. هذا الحياة .. في .. في .. في القانون و
+
+774
+00:54:07,600 --> 00:54:10,220
+حتى في الانتصار .. نفس الشيء .. نحن لدينا اتفاق ..
+
+775
+00:54:10,220 --> 00:54:17,180
+واحد قوي و واحد ضعيف .. الواحد القوي يأخذ فرصة من
+
+776
+00:54:17,180 --> 00:54:23,320
+موقفه .. و الضعيف سوف يسرد .. يقول لا .. سوف لا
+
+777
+00:54:23,320 --> 00:54:26,580
+يقول لا .. لا يستطيع أن يقول لا .. هذا هو الحال
+
+778
+00:54:26,580 --> 00:54:30,040
+هنا .. و أنت تدفع في أحد الحكومة ..
+
+779
+00:54:34,250 --> 00:54:38,070
+one person taking advantage of a position of power
+
+780
+00:54:38,070 --> 00:54:40,990
+over another person okay one is taking advantage
+
+781
+00:54:40,990 --> 00:54:48,450
+position of power like can be sometime هي lawyer
+
+782
+00:54:48,450 --> 00:54:53,030
+and a client, husband and wife and this is not the
+
+783
+00:54:53,030 --> 00:54:55,710
+whole situation like sometimes the wife can be
+
+784
+00:54:55,710 --> 00:54:59,410
+more strong than the husbandأحيانًا ما أقوله هو
+
+785
+00:54:59,410 --> 00:55:04,470
+مستخدم ومستخدم والد وطفل أحيانًا ليس كذلك، يمكن أن
+
+786
+00:55:04,470 --> 00:55:08,610
+يكون المقابل، قوت الطفل قوته قوته قوته قوته قوته
+
+787
+00:55:08,610 --> 00:55:08,750
+قوته قوته قوته قوته قوته قوته قوته قوته قوته قوته
+
+788
+00:55:08,750 --> 00:55:09,230
+قوته قوته قوته قوته قوته قوته قوته قوته قوته قوته
+
+789
+00:55:09,230 --> 00:55:10,010
+قوته قوته قوته قوته قوته قوته قوته قوته قوته قوته
+
+790
+00:55:10,010 --> 00:55:11,270
+قوته قوته قوته قوته قوته قوته قوته قوته قوته قوته
+
+791
+00:55:11,270 --> 00:55:12,110
+قوته قوته قوته قوته قوته قوته قوته قوته قوته قوته
+
+792
+00:55:29,200 --> 00:55:32,520
+solicitor اللي هو lawyer in in the UK they called
+
+793
+00:55:32,520 --> 00:55:35,220
+him solicitor and barrister solicitor in office
+
+794
+00:55:35,220 --> 00:55:39,420
+barrister in court lawyer and client husband and
+
+795
+00:55:39,420 --> 00:55:43,140
+wife we have a special relationship one is taken
+
+796
+00:55:43,140 --> 00:55:45,960
+advantage sometimes can be even between teacher
+
+797
+00:55:45,960 --> 00:55:49,940
+and students one student can have his own business
+
+798
+00:55:49,940 --> 00:55:53,180
+a teacher going to buy something from that
+
+799
+00:55:53,180 --> 00:55:56,740
+business I want it's cheap otherwise you will not
+
+800
+00:55:56,740 --> 00:56:00,950
+pass the examأليس كذلك؟ إنها ليست محاولة، إنها
+
+801
+00:56:00,950 --> 00:56:08,070
+تحرير، إنها تحرير غير حقيقية، مثل إجراء .. إجراء
+
+802
+00:56:08,070 --> 00:56:13,110
+الانفعال من واحد إلى الثانية جزء، إنها مجرد إجراء
+
+803
+00:56:13,110 --> 00:56:17,470
+انفعال، وهذا سيؤثر على التعامل بشكل نقلي، في
+
+804
+00:56:17,470 --> 00:56:20,470
+الواقع إذا كان لدينا حالة مثل هذه، هل لدينا اهتمام
+
+805
+00:56:20,470 --> 00:56:27,770
+كامل؟ نعم أو لا؟ هل لدينا اهتمام؟الجمهور قد لا
+
+806
+00:56:27,770 --> 00:56:30,910
+يكون لديه اهتمام لأنهم ليسوا لديهم اختيار اخر ولكن
+
+807
+00:56:30,910 --> 00:56:35,670
+يمكنك أن تقبل و يمكنك أن ترفض انه ليس فرصة فرصة
+
+808
+00:56:35,670 --> 00:56:39,790
+فرصة فرصة فرصة فرصة فرصة فرصة فرصة فرصة فرصة فرصة
+
+809
+00:56:39,790 --> 00:56:39,890
+فرصة فرصة فرصة فرصة فرصة فرصة فرصة فرصة فرصة فرصة
+
+810
+00:56:39,890 --> 00:56:43,010
+فرصة فرصة فرصة فرصة فرصة فرصة فرصة فرصة فرصة فرصة
+
+811
+00:56:43,010 --> 00:56:46,810
+فرصة فرصة فرصة فرصة فرصة فرصة فرصة فرصة فرصة فرصة
+
+812
+00:56:46,810 --> 00:56:53,370
+فرص
+
+813
+00:56:56,240 --> 00:57:13,260
+yes it's a good point go on if it
+
+814
+00:57:13,260 --> 00:57:17,380
+was you as a judge what can you do you have a case
+
+815
+00:57:17,380 --> 00:57:24,860
+between father and his son they have a contract
+
+816
+00:57:25,840 --> 00:57:28,960
+buying something one of them is buying some items
+
+817
+00:57:28,960 --> 00:57:31,640
+from the other both of them working as merchants
+
+818
+00:57:31,640 --> 00:57:35,820
+but the father exercised his own power influence
+
+819
+00:57:35,820 --> 00:57:40,020
+over his son then the son later on after one year
+
+820
+00:57:40,020 --> 00:57:44,260
+came to complain that his father abused him maybe
+
+821
+00:57:44,260 --> 00:57:47,440
+the lawyer and the client and the lawyer محمد and
+
+822
+00:57:47,440 --> 00:57:49,840
+the client they have a strong special relationship
+
+823
+00:57:49,840 --> 00:57:55,670
+husband and wifeالعزيز يجعل زوجته تسحب ميزاتها
+
+824
+00:57:55,670 --> 00:57:59,030
+لإنسانها لإنسانها لإنسانها لإنسانها لإنسانها
+
+825
+00:57:59,030 --> 00:58:00,830
+لإنسانها لإنسانها لإنسانها لإنسانها لإنسانها
+
+826
+00:58:00,830 --> 00:58:01,190
+لإنسانها لإنسانها لإنسانها لإنسانها لإنسانها
+
+827
+00:58:01,190 --> 00:58:01,830
+لإنسانها لإنسانها لإنسانها لإنسانها لإنسانها
+
+828
+00:58:01,830 --> 00:58:02,910
+لإنسانها لإنسانها لإنسانها لإنسانها لإنسانها
+
+829
+00:58:02,910 --> 00:58:07,550
+لإنسانها لإنسانها
+
+830
+00:58:07,550 --> 00:58:13,690
+لإنسانها لإنسانهالأنه تأثير القوة، ليس قوة، إنها
+
+831
+00:58:13,690 --> 00:58:18,810
+تأثير، لأنها لم ترغب بإغضابه، لم ترغب بإنجاز
+
+832
+00:58:18,810 --> 00:58:23,590
+زوجته، ثم أعطاه المال لقليل من المال، لإجازته،
+
+833
+00:58:23,590 --> 00:58:28,430
+إنها مقاومة، لكنها تحت تأثير غير حقيقي، بعد أن هما
+
+834
+00:58:28,430 --> 00:58:31,970
+اختلافوا، ثم لا يمكنها أن تدعي ذلك مرة أخرى، هل
+
+835
+00:58:31,970 --> 00:58:35,810
+المقام سيقبل هذه الحالة أم لا؟ لا، لديها الوضع،
+
+836
+00:58:35,810 --> 00:58:40,490
+هيفعلها بشأن نفسها، ليس بشأن نفسها هل أنت متأكد؟
+
+837
+00:58:42,440 --> 00:58:45,840
+حسنا، لدينا بعض الحالات الأخرى، خصوصا في غزا هنا،
+
+838
+00:58:45,840 --> 00:58:52,220
+الناس تبحث عن نظام الحيوانات، نظام الحيوانات، إذا
+
+839
+00:58:52,220 --> 00:58:57,380
+كان لدينا المال خلفنا، بعد أن والدنا عبر الطريق،
+
+840
+00:58:57,380 --> 00:59:04,060
+هذا المال و هذه الحيوانات ستكون مقاطعة بين أطفاله،
+
+841
+00:59:04,060 --> 00:59:07,300
+رجال و أفراد، في بعض المجتمعات مثل غزا هنا، بعض
+
+842
+00:59:07,300 --> 00:59:11,880
+الناس، ما يفعلونه، الفتاة ليس لها أي شيءأو قد تحصل
+
+843
+00:59:11,880 --> 00:59:15,640
+على نصف من ما يجب أن تحصل عليه مثلًا إذا كانت من
+
+844
+00:59:15,640 --> 00:59:18,380
+المفروض أن تحصل على 50 ألف دينار يمكنهم أن يعطيها
+
+845
+00:59:18,380 --> 00:59:24,560
+10 ألف دينار و يقولون هذا كافي لك هل هذا صحيح؟ ليس
+
+846
+00:59:24,560 --> 00:59:29,500
+كذلك بالطبع ليس كذلك قد تقبلها لأنها لا تريد أن
+
+847
+00:59:29,500 --> 00:59:34,320
+تغضب أخوها تريد أن تبقى في التواصل مع أخوها ولكن
+
+848
+00:59:34,320 --> 00:59:39,330
+داخل نفسها هي ليست سعيدةShe does not have she does
+
+849
+00:59:39,330 --> 00:59:41,710
+not have a full intention. She can cancel at any
+
+850
+00:59:41,710 --> 00:59:45,670
+time She can cancel it. She has later on. She has
+
+851
+00:59:45,670 --> 00:59:49,190
+the right to complain against him Now in such case
+
+852
+00:59:49,190 --> 00:59:52,190
+and you influence as I said, it can be sometimes
+
+853
+00:59:52,190 --> 00:59:57,770
+teacher student lawyer client husband wife father
+
+854
+00:59:57,770 --> 01:00:03,650
+child in such cases As an equitable doctrine
+
+855
+01:00:03,650 --> 01:00:10,930
+equitable doctrineالحكومة لديها تسمح لـ VTA بهذه
+
+856
+01:00:10,930 --> 01:00:15,650
+التعاملات، فهو مقرر للحكومة التعاملات هي في يدي ..
+
+857
+01:00:15,650 --> 01:00:22,250
+في يدي الحكومات، الحكومة الحكومة تستطيع تخطيطها
+
+858
+01:00:22,250 --> 01:00:29,210
+بنسبة إلى دكتورية متفارقة مذهب العدالة بنسبة إلى
+
+859
+01:00:29,210 --> 01:00:32,890
+حقوق وإيقوة وإصلاح، فهو مقرر للحكومة تبحث عنها
+
+860
+01:00:32,890 --> 01:00:37,970
+وتتعامل مع الوضعو أرى إذا كان هناك حاجة لإنهاء هذا
+
+861
+01:00:37,970 --> 01:00:41,310
+التجارب أو لا ربما لا ربما ما أستطيع أن أفعله إذا
+
+862
+01:00:41,310 --> 01:00:45,930
+كنت مجلس انا سأموذج كيف؟ أستطيع أن أخذ المال من A
+
+863
+01:00:45,930 --> 01:00:51,210
+و أعطيه ل B أستطيع أن أخذ بعض الأشياء من A و
+
+864
+01:00:51,210 --> 01:00:57,010
+أعطيها ل B لأن هذا ايقاوة و عادية، يتعامل مع بعض
+
+865
+01:00:57,010 --> 01:00:59,310
+الناس في بعض الحالات لا نستطيع أن نجد هذا علاقات
+
+866
+01:00:59,310 --> 01:01:03,930
+خاصة ليس كذلك، ماذا أستطيع أن أفعل؟ مثل ما هو
+
+867
+01:01:03,930 --> 01:01:08,030
+إسمك؟حنين who is your best friend here؟ we don't
+
+868
+01:01:08,030 --> 01:01:15,710
+have؟ is she your best friend؟ اه كده حق، if you
+
+869
+01:01:15,710 --> 01:01:19,770
+hesitate for one second ده she is not anyone here
+
+870
+01:01:19,770 --> 01:01:25,550
+are two best friends here؟ no؟ no best friends؟
+
+871
+01:01:25,550 --> 01:01:31,930
+okay no I believe you that's fine حنين أنت؟ دي دي
+
+872
+01:01:39,450 --> 01:01:43,130
+Anyway, if we don't have this special relationship
+
+873
+01:01:43,130 --> 01:01:46,710
+like husband and wife, father and son, we can have
+
+874
+01:01:46,710 --> 01:01:50,050
+sometimes a relationship like between حنين and
+
+875
+01:01:50,050 --> 01:01:54,410
+ديلي. This .. this is based on trust. It's fine,
+
+876
+01:01:54,490 --> 01:01:59,190
+she's ديلي, isn't she? Okay, now this .. this type
+
+877
+01:01:59,190 --> 01:02:01,770
+of relationship, this is special. Friendship .. do
+
+878
+01:02:01,770 --> 01:02:07,890
+you trust her? Do you trust her?لأ اذا كانت تطلب
+
+879
+01:02:07,890 --> 01:02:12,110
+منك 5000 دينار اذا كان لديك المال اذا كان لديك
+
+880
+01:02:12,110 --> 01:02:17,450
+المال و كانت تطلب منك 5000 دينار هل ستدفعها او لا؟
+
+881
+01:02:17,450 --> 01:02:23,230
+بالطبع ربما لا انا لا اعرف في حالة حقيقية ربما لا
+
+882
+01:02:23,230 --> 01:02:25,350
+ليس كذلك لماذا تقول هذا؟ لأنك لا يوجد لديك المال
+
+883
+01:02:25,350 --> 01:02:30,750
+الأن نحن لدينا بعض الوقت اشخاص مميزين اذا كانوا
+
+884
+01:02:30,750 --> 01:02:35,410
+أصدقاء قوى اشخاص مميزين يوجدون علاقات مميزة و هذا
+
+885
+01:02:35,410 --> 01:02:35,730
+يمكن أن يكون
+
+886
+01:02:38,710 --> 01:02:43,770
+ثقافة و انا أعرف أن بعض الأصحاب بعض الأصحاب يثقوا
+
+887
+01:02:43,770 --> 01:02:46,570
+بعضهم البعض أكتر من أصحاب العائلة حتى نعم أليس
+
+888
+01:02:46,570 --> 01:02:49,610
+كذلك؟ يمكنك أن تتكلم مع صديقك عن أشياء لا يمكنك أن
+
+889
+01:02:49,610 --> 01:02:52,810
+تتكلم مع أمك و أختك يمكنك أن تثق بها في مالكك و في
+
+890
+01:02:52,810 --> 01:02:58,530
+حياتك أكتر من أن تثق بأختك ثم إذا طلبت منك أن تقوم
+
+891
+01:02:58,530 --> 01:03:02,850
+بتعامل معها تعامل معها و كلا الاثنين مخاطرين في
+
+892
+01:03:02,850 --> 01:03:09,590
+السوق و أصحاب في نفس الوقتfriends can exert some
+
+893
+01:03:09,590 --> 01:03:12,550
+kind of influence like if she ask you for
+
+894
+01:03:12,550 --> 01:03:16,190
+something you will not be hesitant to say no you
+
+895
+01:03:16,190 --> 01:03:18,170
+cannot say it because she is your best friend you
+
+896
+01:03:18,170 --> 01:03:21,690
+trust her you have a strong relationship then we
+
+897
+01:03:21,690 --> 01:03:25,850
+can presume in this case even the same thing that
+
+898
+01:03:25,850 --> 01:03:29,290
+we have influence your best friend ask you for
+
+899
+01:03:29,290 --> 01:03:32,270
+twenty shekels only twenty shekels you will not
+
+900
+01:03:32,270 --> 01:03:36,350
+say no أكيد أه مش مصدقين
+
+901
+01:03:39,820 --> 01:03:43,260
+في هذه الحالة، إذا لم نجد علاقة خاصة، نستطيع أن
+
+902
+01:03:43,260 --> 01:03:48,000
+نستعينها مع ثقافة،
+
+903
+01:03:48,000 --> 01:03:51,080
+نستطيع
+
+904
+01:03:51,080 --> 01:04:00,560
+أن نعتقد أننا نستطيع أن نجد تأثير و هذا تأثير غير
+
+905
+01:04:00,560 --> 01:04:05,260
+متوقع، واحد منهم أقوى من الآخر، في هذه الحالة هنا
+
+906
+01:04:06,100 --> 01:04:08,600
+سيكون هذا التجارب و كل التجارب تتعامل مع اندو اندو
+
+907
+01:04:08,600 --> 01:04:11,860
+اندو اندو اندو اندو اندو اندو اندو اندو اندو اندو
+
+908
+01:04:11,860 --> 01:04:11,920
+اندو اندو اندو اندو اندو اندو اندو اندو اندو اندو
+
+909
+01:04:11,920 --> 01:04:13,400
+اندو اندو اندو اندو اندو اندو اندو اندو اندو اندو
+
+910
+01:04:13,400 --> 01:04:15,720
+اندو اندو اندو اندو اندو اندو اندو اندو اندو اندو
+
+911
+01:04:15,720 --> 01:04:17,160
+اندو اندو اندو اندو اندو اندو اندو اندو اندو اندو
+
+912
+01:04:17,160 --> 01:04:21,540
+اندو اندو اندو اندو اندو اندو اندو اندو اندو اندو
+
+913
+01:04:21,540 --> 01:04:27,200
+اندو اندو اندو اندو اندو اندو
+
+914
+01:04:31,190 --> 01:04:33,610
+هذا التطبيق يمكن أن يتم تحميله و بعد ذلك يمكننا أن
+
+915
+01:04:33,610 --> 01:04:38,210
+نستغل بعض الجمهورات. انتقل إلى احتمال الشرطة أن
+
+916
+01:04:38,210 --> 01:04:42,610
+يستخدم رأسه بالحقوق و الحقوق. شكرا جزيلا جزيلا
+
+917
+01:04:42,610 --> 01:04:46,150
+لوقتك و سنكمل ما لدينا في الوقت القادم
+
diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/Hja0vbDM124_postprocess.srt b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/Hja0vbDM124_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..8edb3057314ad88f2d3c2f004cff2288674e291c
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/Hja0vbDM124_postprocess.srt
@@ -0,0 +1,4308 @@
+1
+00:00:13,900 --> 00:00:17,440
+Okay السلام عليكم this is the second lecture on
+
+2
+00:00:17,440 --> 00:00:21,060
+bankruptcy bankruptcy
+
+3
+00:00:21,060 --> 00:00:24,640
+we have in general we have liquidation and
+
+4
+00:00:24,640 --> 00:00:29,360
+reorganizationبعض النقطة التي يجب أن ننظر إليها و
+
+5
+00:00:29,360 --> 00:00:33,260
+نتكلم عنها عندما نتكلم عن الانهيار و الانهيار
+
+6
+00:00:33,260 --> 00:00:38,260
+عندما نتكلم عن الانهيار و الانهيار عندما نتكلم عن
+
+7
+00:00:38,260 --> 00:00:38,840
+الانهيار و الانهيار عندما نتكلم عن الانهيار و
+
+8
+00:00:38,840 --> 00:00:39,040
+الانهيار عندما نتكلم عن الانهيار و الانهيار عندما
+
+9
+00:00:39,040 --> 00:00:39,440
+نتكلم عن الانهيار و الانهيار عندما نتكلم عن
+
+10
+00:00:39,440 --> 00:00:39,500
+الانهيار و الانهيار عندما نتكلم عن الانهيار و
+
+11
+00:00:39,500 --> 00:00:41,200
+الانهيار عندما نتكلم عن الانهيار و الانهيار عندما
+
+12
+00:00:41,200 --> 00:00:42,600
+نتكلم عن الانهيار و الانهيار عندما نتكلم عن
+
+13
+00:00:42,600 --> 00:00:55,680
+الانهيار و الانهيار عند
+
+14
+00:00:55,890 --> 00:01:00,430
+والإيقاع كما ترى أننا لدينا الأموال المفروضة
+
+15
+00:01:00,430 --> 00:01:08,490
+والأموال المفروضة الأموال المفروضة لا الأموال
+
+16
+00:01:08,490 --> 00:01:14,410
+المفروضة يجب أن تتم اختيارها من البياناتنحن لدينا
+
+17
+00:01:14,410 --> 00:01:18,450
+أموال مفروضة و لا اموال مفروضة يجب أن نبقى الأموال
+
+18
+00:01:18,450 --> 00:01:24,030
+المفروضة المال المنزل كل شيء يجب أن يكون هنا
+
+19
+00:01:24,030 --> 00:01:28,850
+لإحتجاز المال والعائلة لديه يجب أن نبقى يجب أن
+
+20
+00:01:28,850 --> 00:01:33,390
+نغادر أي شيء أكتر يجب أن نأخذه وهو ما يسمى أموال
+
+21
+00:01:33,390 --> 00:01:38,170
+لا مفروضة يجب أن نأخذه يجب أن نسحب ويجب أن نقوم
+
+22
+00:01:38,170 --> 00:01:42,810
+بتقاط المال بين المستخدمين لدينا المال يجب أن نركز
+
+23
+00:01:42,810 --> 00:01:43,110
+على
+
+24
+00:01:56,160 --> 00:02:01,920
+والاستثمارات الانتجارية الانتجارية
+
+25
+00:02:01,920 --> 00:02:13,820
+تصفية تصفية
+
+26
+00:02:13,820 --> 00:02:14,660
+تصفية تصفية تصفية تصفية تصفية تصفية تصفية تصفية
+
+27
+00:02:14,660 --> 00:02:14,740
+تصفية تصفية تصفية تصفية تصفية تصفية تصفية تصفية
+
+28
+00:02:14,740 --> 00:02:14,760
+تصفية تصفية تصفية تصفية تصفية تصفية تصفية تصفية
+
+29
+00:02:14,760 --> 00:02:17,800
+تصفية تصفية تصفية تصفية تصفية تصفية تصفية تصفية
+
+30
+00:02:17,800 --> 00:02:21,460
+تصفية
+
+31
+00:02:22,340 --> 00:02:25,940
+including the cash, the car, the house, the land
+
+32
+00:02:25,940 --> 00:02:29,780
+everything you have which is none exempted which
+
+33
+00:02:29,780 --> 00:02:33,300
+is none protected none exempted assets something
+
+34
+00:02:33,300 --> 00:02:36,240
+extra money you have extra money more than you
+
+35
+00:02:36,240 --> 00:02:39,020
+need for your basic life we have to take it away
+
+36
+00:02:39,020 --> 00:02:42,860
+and then we have to sell we take the money and
+
+37
+00:02:42,860 --> 00:02:46,020
+then we divide it between creditors and number
+
+38
+00:02:46,020 --> 00:02:51,380
+three number one okay number three is you have to
+
+39
+00:02:51,380 --> 00:02:57,320
+pay the moneyمال المال اللي لديك ومال المال اللي
+
+40
+00:02:57,320 --> 00:02:59,240
+لديك ومال المال اللي لديك ومال المال اللي لديك
+
+41
+00:02:59,240 --> 00:02:59,260
+المال اللي لديك ومال المال اللي لديك ومال المال
+
+42
+00:02:59,260 --> 00:02:59,960
+اللي لديك ومال المال اللي لديك ومال المال اللي
+
+43
+00:02:59,960 --> 00:03:01,240
+لديك ومال المال اللي لديك ومال المال اللي لديك
+
+44
+00:03:01,240 --> 00:03:01,260
+ومال المال اللي لديك ومال المال اللي لديك ومال
+
+45
+00:03:01,260 --> 00:03:02,460
+اللي لديك ومال المال اللي لديك ومال المال اللي
+
+46
+00:03:02,460 --> 00:03:06,260
+لديك ومال المال اللي لديك ومال المال اللي لديك
+
+47
+00:03:06,260 --> 00:03:22,300
+ومال
+
+48
+00:03:22,300 --> 00:03:28,150
+المالوهو يسمى اتجارة اتجارة
+
+49
+00:03:28,150 --> 00:03:35,710
+اتجارة اتجارة اتجارة اتجارة اتجارة اتجارة اتجارة
+
+50
+00:03:35,710 --> 00:03:39,070
+اتجارة
+
+51
+00:03:39,070 --> 00:03:49,570
+اتجارة اتجارة
+
+52
+00:03:49,850 --> 00:03:52,290
+نشوف هذا في الولايات المتحدة و الUSA و كم وقت
+
+53
+00:03:52,290 --> 00:03:58,110
+تستخدمه من الوقت اللي لدينا بانكروبسي order لدينا
+
+54
+00:03:58,110 --> 00:04:01,770
+بانكروبسي order هذه .. عندما نحصل على هذه القرارة
+
+55
+00:04:01,770 --> 00:04:05,190
+فهي مجرد قرار بانكروبسي order إنها قرارة، إنها
+
+56
+00:04:05,190 --> 00:04:08,890
+قرار أخير ثم تصبحين بانكروبت و عندما تصبحين
+
+57
+00:04:08,890 --> 00:04:14,150
+بانكروبت فهي قصة مختلفة تماما، ليس مثل ديتر، ديتر
+
+58
+00:04:14,150 --> 00:04:20,580
+ليس مثل بانكروبتمفلس still you might take more
+
+59
+00:04:20,580 --> 00:04:24,500
+steps to be a bankrupt you can be a debtor but you
+
+60
+00:04:24,500 --> 00:04:29,340
+can pay the debts sometimes .. sometimes you can
+
+61
+00:04:29,340 --> 00:04:35,220
+be in debt but you can pay and you are in due to
+
+62
+00:04:35,220 --> 00:04:39,330
+pay the money and you pay them on timeفي هذه
+
+63
+00:04:39,330 --> 00:04:42,530
+الحالة هنا فلا أحد يستطيع أن يطلب منك انتصارك
+
+64
+00:04:42,530 --> 00:04:46,010
+يمكنك أن تبقى في عملك ولكن عندما تتوقف هنا عندما
+
+65
+00:04:46,010 --> 00:04:50,490
+تتوقف لا يمكنك أن تدفع الأموال بعد الأن لا يمكنك
+
+66
+00:04:50,490 --> 00:04:53,450
+أن تأخذ اي خطوط أكتر لدفع مالك لك ثم نستطيع أن
+
+67
+00:04:53,450 --> 00:04:57,590
+نطلب منك انتصارك ، لذلك الاحتياطات مفتوحة من
+
+68
+00:04:57,590 --> 00:05:05,210
+المستخدمين المفتوحين هنا مع وقت ووانتج اعتبارات
+
+69
+00:05:05,210 --> 00:05:13,110
+صحيحة و صحيحة اعتبارات صحيحة اعتبارات
+
+70
+00:05:13,110 --> 00:05:14,370
+صحيحة اعتبارات صحيحة اعتبارات صحيحة اعتبارات صحيحة
+
+71
+00:05:14,370 --> 00:05:16,510
+اعتبارات صحيحة اعتبارات صحيحة اعتبارات صحيحة
+
+72
+00:05:16,510 --> 00:05:16,610
+اعتبارات صحيحة اعتبارات صحيحة اعتبارات صحيحة
+
+73
+00:05:16,610 --> 00:05:17,090
+اعتبارات صحيحة اعتبارات صحيحة اعتبارات صحيحة
+
+74
+00:05:17,090 --> 00:05:20,990
+اعتبارات صحيحة اعتبارات
+
+75
+00:05:20,990 --> 00:05:31,950
+صحيحة اعتبارات صحيحة اعتبار
+
+76
+00:05:34,410 --> 00:05:37,010
+هو قريب من أن يكون مغامر و يكون لدينا سؤال في
+
+77
+00:05:37,010 --> 00:05:42,390
+السجن ثم اني أعطى رواية وقت محدد ووقت محدد لجميع
+
+78
+00:05:42,390 --> 00:05:46,330
+المستخدمين الذين يقابلوا في هذه الحالة اذا كان
+
+79
+00:05:46,330 --> 00:05:50,130
+لديهم أمر مغامر مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+80
+00:05:50,130 --> 00:05:51,090
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+81
+00:05:51,090 --> 00:05:51,590
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+82
+00:05:51,590 --> 00:06:03,210
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجر
+
+83
+00:06:03,860 --> 00:06:07,480
+وانت لم تقوم بمشاركة تلك المصادر فسيخسر مالك حتى
+
+84
+00:06:07,480 --> 00:06:10,440
+اذا كان لديك مثلا دعنا نقول ان انا مات من خلال نصف
+
+85
+00:06:10,440 --> 00:06:17,060
+مليون دولار وكل ما انا لدي اليوم 150 ألف دولار ثم
+
+86
+00:06:17,060 --> 00:06:22,000
+السجن سيأخذ المال و يقوم بتقسيمه بين 9 مصادر ولكن
+
+87
+00:06:22,000 --> 00:06:25,660
+اذا واحد لم يقوم بمشاركة المصادر فكان مغضب ولم
+
+88
+00:06:25,660 --> 00:06:30,320
+يعرف ولم يتبع هذا هو مشكلته الخاصة لنا لا يهم إذا
+
+89
+00:06:30,320 --> 00:06:33,730
+لم يقوم بمشاركة المصادر على وقتثم لا يستطيع أن
+
+90
+00:06:33,730 --> 00:06:37,190
+يأتي لاحقا و يقول انا نسيت انا لم اطلب مالي اريد
+
+91
+00:06:37,190 --> 00:06:39,750
+مالي اريد قطعة من المال اللي اريد مالي اريد مالي
+
+92
+00:06:39,750 --> 00:06:42,370
+قطعة من المال اللي اريد مالي مالي مالي مالي مالي
+
+93
+00:06:42,370 --> 00:06:42,550
+مالي مالي مالي مالي مالي مالي مالي مالي مالي مالي
+
+94
+00:06:42,550 --> 00:06:42,590
+مالي مالي مالي مالي مالي مالي مالي مالي مالي مالي
+
+95
+00:06:42,590 --> 00:06:51,910
+مالي مالي مالي مالي مالي مال
+
+96
+00:06:51,950 --> 00:06:58,290
+واضح وليس مقارنة مثلا انا كنت في عقد ل 10 اشخاص و
+
+97
+00:06:58,290 --> 00:07:03,010
+الأن ليس لدينا مقارنة عن هذا ثم المال يجب أن يكون
+
+98
+00:07:03,010 --> 00:07:09,570
+مقاطع على نظام يسمى راتب
+
+99
+00:07:09,570 --> 00:07:17,190
+بي برسنتج المال الأموات تلك الأموات اللي ليست
+
+100
+00:07:17,190 --> 00:07:23,400
+مجالية للعقد اللي تم تجمعهايمكن أن تتسوق منها،
+
+101
+00:07:23,400 --> 00:07:29,000
+نأخذ المال و نقوم بتقاطه بين المستخدمين على نظام
+
+102
+00:07:29,000 --> 00:07:34,720
+يسمى بروراتن، percentage لأنه ليس فرصة أن يكون
+
+103
+00:07:34,720 --> 00:07:38,620
+لديك مستخدم واحد بميزة 50 ألف ومستخدم واحد بميزة
+
+104
+00:07:38,620 --> 00:07:43,840
+10 ألف يحصل على نفس المال، لا، فهو مصمم من كم
+
+105
+00:07:43,840 --> 00:07:48,490
+المال الذي ستحصل عليه، كم المال الذي ستستخدمهالشخص
+
+106
+00:07:48,490 --> 00:07:52,490
+المالي يستطيع أن يقوم بتقليل المال عن ذلك ويوجد
+
+107
+00:07:52,490 --> 00:07:57,830
+أشياء مختلفة يجب أن نذكرها هنا حتى لو قمنا بتقليل
+
+108
+00:07:57,830 --> 00:08:03,010
+المال وقمنا بتقليل المال بين المستخدمين لدينا
+
+109
+00:08:03,010 --> 00:08:10,650
+أوليات بين المأمن والمأمن هنا مأمن و
+
+110
+00:08:13,810 --> 00:08:16,710
+Look at this in the exam, this is so important, we
+
+111
+00:08:16,710 --> 00:08:19,470
+have two types of creditors, one of them is called
+
+112
+00:08:19,470 --> 00:08:22,910
+secured and the second is unsecured, most
+
+113
+00:08:22,910 --> 00:08:26,970
+creditors, most of them are unsecured, which we
+
+114
+00:08:26,970 --> 00:08:30,350
+call them general creditors, unsecured, then you
+
+115
+00:08:30,350 --> 00:08:34,970
+don't have something guaranteed, those secured
+
+116
+00:08:34,970 --> 00:08:39,770
+creditors, they have guarantees, فيه ضمنانهي ممكن
+
+117
+00:08:39,770 --> 00:08:42,330
+تكون السيارة، ممكن تكون المنزل، ممكن تكون المال،
+
+118
+00:08:42,330 --> 00:08:46,030
+هم لديهم بعض التأكيدات، لكن بعد ذلك، ما يجب أن
+
+119
+00:08:46,030 --> 00:08:48,210
+نفعله في هذا، نحن لدينا المال، ماذا نستطيع أن نفعل
+
+120
+00:08:48,210 --> 00:08:52,490
+بهذا؟ إذا كان لدينا أولوية، من يمكن أن ندفع أولا؟
+
+121
+00:08:52,490 --> 00:08:57,250
+الأمان، ومال يبقى خلفه يمكن أن يكون مقاطع بين
+
+122
+00:08:57,250 --> 00:09:04,140
+المستثمرين الأمانية، فأولا يجب أن ندفع الأمانالمال
+
+123
+00:09:04,140 --> 00:09:06,580
+المتبقى بعد ذلك إذا كان لدينا او اثنين من
+
+124
+00:09:06,580 --> 00:09:08,440
+المستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+125
+00:09:08,440 --> 00:09:08,680
+مستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+126
+00:09:08,680 --> 00:09:08,700
+مستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+127
+00:09:08,700 --> 00:09:10,120
+مستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+128
+00:09:10,120 --> 00:09:11,440
+مستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+129
+00:09:11,440 --> 00:09:14,120
+مستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+130
+00:09:14,120 --> 00:09:14,180
+مستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+131
+00:09:14,180 --> 00:09:21,680
+مستخدمين مستخدمين مستخدمين مستخدمين
+
+132
+00:09:21,680 --> 00:09:31,780
+مستخدمين
+
+133
+00:09:34,290 --> 00:09:38,570
+في حالة مختلفة، لدينا تحويل، وهذا يسمى في الولايات
+
+134
+00:09:38,570 --> 00:09:45,530
+المتحدة Voluntary V Voluntary Arrangement بين
+
+135
+00:09:45,530 --> 00:09:50,290
+الاتجاهين، سننظر إلى ذلك لاحقًا، ولكن في تحويل
+
+136
+00:09:50,290 --> 00:09:55,090
+الانفجار، إنه تمامًا عكس ما لدينا في الاستخدام، في
+
+137
+00:09:55,090 --> 00:10:00,030
+الاستخدام نحن نستخدم، نخلق العمل، ولكن هنا لا
+
+138
+00:10:00,030 --> 00:10:03,930
+يمكنك أن تستمربقى موجودا , يمكنك أن تفعل عملك
+
+139
+00:10:03,930 --> 00:10:06,310
+الخاص بيبقى موجودا و تستمتع بعملك الخاص بيبقى
+
+140
+00:10:06,310 --> 00:10:09,230
+موجودا و تستمتع بعملك الخاص بيبقى موجودا و تستمتع
+
+141
+00:10:09,230 --> 00:10:10,750
+بعملك الخاص بيبقى موجودا و تستمتع بعملك الخاص
+
+142
+00:10:10,750 --> 00:10:13,910
+بيبقى موجودا و تستمتع بعملك الخاص بيبقى موجودا و
+
+143
+00:10:13,910 --> 00:10:17,090
+تستمتع بعملك الخاص بيبقى موجودا و تستمتع بعملك
+
+144
+00:10:17,090 --> 00:10:19,890
+الخاص بيبقى موجودا و تستمتع بعملك الخاص بيبقى
+
+145
+00:10:19,890 --> 00:10:27,230
+موجودا و تستمتع بعملك الخاص بيبقى موجودا
+
+146
+00:10:27,230 --> 00:10:32,950
+و تستمتع بعملك الخاص بيبقI would pay only what I
+
+147
+00:10:32,950 --> 00:10:37,910
+have in liquidation if I have only 10% of what I'm
+
+148
+00:10:37,910 --> 00:10:40,890
+supposed to pay then I would pay the 10% and the
+
+149
+00:10:40,890 --> 00:10:46,450
+90% no one can ask me once I have a discharge in
+
+150
+00:10:46,450 --> 00:10:49,610
+the future no one can ask me nothing even if I
+
+151
+00:10:49,610 --> 00:10:51,810
+become a multimillionaire once you have a
+
+152
+00:10:51,810 --> 00:10:57,130
+discharge you have it means freedom relief a new
+
+153
+00:10:57,130 --> 00:11:03,240
+life can forget about the past leave itNow in this
+
+154
+00:11:03,240 --> 00:11:05,420
+situation as you can see that we can keep the
+
+155
+00:11:05,420 --> 00:11:10,220
+assets, we can keep the business and we have to
+
+156
+00:11:10,220 --> 00:11:12,860
+pay the full amount of money, but in this case we
+
+157
+00:11:12,860 --> 00:11:20,380
+have a new time notice, we have to have the money
+
+158
+00:11:20,380 --> 00:11:25,960
+to satisfy creditors claim, it's called إعادة
+
+159
+00:11:25,960 --> 00:11:30,770
+الجدولةو إذا كنت مالك و أجب أن أدفع نصف مليون لعمل
+
+160
+00:11:30,770 --> 00:11:33,390
+ولكن ليس لدي المال، فيمكنك أن تعطيني ملاحظة،
+
+161
+00:11:33,390 --> 00:11:36,950
+الوقت، هذا سيكون خمس سنوات أو خمس سنوات أو ثلاث
+
+162
+00:11:36,950 --> 00:11:41,370
+سنوات، فهذا يعتمد على المادة المالية، ثم خلال ذلك
+
+163
+00:11:41,370 --> 00:11:46,350
+الوقت سأكون قادر على أن أدفع المادة المالية. الآن،
+
+164
+00:11:46,350 --> 00:11:51,250
+بعض الناس يريدون أن يكونوا مستخدينين، و لا يريدون
+
+165
+00:11:51,250 --> 00:11:54,630
+أن يكونوا مستخدينين الأخرينلأن في المحافظة، أعني
+
+166
+00:11:54,630 --> 00:11:59,670
+في التعامل هنا، نحن نعيش .. نعيش من الانسلفات،
+
+167
+00:11:59,670 --> 00:12:08,870
+لسنا لدينا المحافظة هنا في التعامل، نحن نعيش من
+
+168
+00:12:08,870 --> 00:12:12,910
+الانسلفات، نحن نعيش من المحافظة، نستطيع أن نبقى في
+
+169
+00:12:12,910 --> 00:12:17,590
+عملنا، نستطيع أن نستمر في ذلك، نستطيع هنا و نستطيع
+
+170
+00:12:17,590 --> 00:12:22,110
+أن نكون حمايةنحن نستطيع أن نكون حماية من أي إدعاء،
+
+171
+00:12:22,110 --> 00:12:24,190
+فالوحيء اللي يمكنك أن تحصل عليه مالك إذا كان لديك
+
+172
+00:12:24,190 --> 00:12:30,810
+مؤسسة مرتبطة مرة أخرى هو الحكومة، إنها قناة جديدة،
+
+173
+00:12:30,810 --> 00:12:33,690
+إنها الطريقة الوحيدة التي يمكنك أن تكون فيها مؤسسة
+
+174
+00:12:33,690 --> 00:12:37,150
+مرتبطة مرة أخرى لأن هنا نحن لدينا خطة، وهذه الخطة،
+
+175
+00:12:37,150 --> 00:12:43,500
+نحن لدينا اقتراحفي هذه التطبيقه، كدتر، كنت دتر من
+
+176
+00:12:43,500 --> 00:12:47,200
+نصف مليون دولار، أستطيع أن أقدم تطبيقه يقول أنه
+
+177
+00:12:47,200 --> 00:12:51,480
+يمكنني أن أدفعك المال، ولكن يحتاج 2 سنة، لكن يجب
+
+178
+00:12:51,480 --> 00:12:55,240
+أن أحدث في التطبيق كم المال يمكنني أن أدفعه كل
+
+179
+00:12:55,240 --> 00:12:59,820
+أشهرand I can specify how can I get the money and
+
+180
+00:12:59,820 --> 00:13:03,400
+I would state some guarantees because if I cannot
+
+181
+00:13:03,400 --> 00:13:05,120
+pay the money they would take it from the
+
+182
+00:13:05,120 --> 00:13:08,320
+guarantees so this stage here in this way
+
+183
+00:13:08,320 --> 00:13:12,200
+reorganization it's not easy to happen quite often
+
+184
+00:13:12,200 --> 00:13:14,100
+people have liquidation they don't have
+
+185
+00:13:14,100 --> 00:13:17,520
+reorganization reorganization will have guarantees
+
+186
+00:13:17,520 --> 00:13:20,680
+في ضمنانwe have guarantees, we have money to be
+
+187
+00:13:20,680 --> 00:13:23,040
+paid, we have somebody to stay in business, so we
+
+188
+00:13:23,040 --> 00:13:26,780
+have to make sure that everything I have stated in
+
+189
+00:13:26,780 --> 00:13:30,380
+the plan is correct and I will have the guarantees
+
+190
+00:13:30,380 --> 00:13:33,660
+and I will have the sponsors so if I don't pay my
+
+191
+00:13:33,660 --> 00:13:38,020
+sponsor اللي هو ال .. what sponsor؟ الضامن he
+
+192
+00:13:38,020 --> 00:13:44,300
+would be instead of meعندما أفعل كل هذا، لا أحد
+
+193
+00:13:44,300 --> 00:13:48,160
+يستطيع أن يطلب مني أن أكون حماية حسنًا، أعطيت نفسي
+
+194
+00:13:48,160 --> 00:13:54,020
+وعد، أنني سأدفعك، حسنًا، سأدفعك، ثم لن تطلب مني
+
+195
+00:13:54,020 --> 00:13:58,180
+مرة أخرى، عليك أن تنتظر حركتك حتى تحصل على المال،
+
+196
+00:13:58,180 --> 00:14:01,100
+ولا أحد أخر يستطيع أن يفعل هذا هنا، البيانات
+
+197
+00:14:01,100 --> 00:14:06,970
+حماية، حماية من ماذا؟معظم حكومات عملية تجارب غير
+
+198
+00:14:06,970 --> 00:14:12,950
+تجارب لا يستطيعون تحقيق أكتر نوع من الحكومات، كل
+
+199
+00:14:12,950 --> 00:14:16,850
+شيء مفرزن، سأجب أن أدفعك، ولكن بداخل الأنظمة،
+
+200
+00:14:16,850 --> 00:14:20,670
+بداخل الأنظمة، بعض الناس يفكرون في تجارب تجارب
+
+201
+00:14:20,670 --> 00:14:22,170
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+202
+00:14:22,170 --> 00:14:22,650
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+203
+00:14:22,650 --> 00:14:23,710
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+204
+00:14:23,710 --> 00:14:31,030
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+205
+00:14:31,030 --> 00:14:34,570
+ت
+
+206
+00:14:34,880 --> 00:14:41,260
+مثلًا تخيل نفسك .. نعم لكن تخيل نفسك كيف .. هل هو
+
+207
+00:14:41,260 --> 00:14:46,420
+جيد أو سيء؟ أنت كدتر في السوق تخيل أنك اليوم مالك
+
+208
+00:14:46,420 --> 00:14:49,420
+و نصف مليون أو اتون مليون باونز لأننا نتكلم عن
+
+209
+00:14:49,420 --> 00:14:52,360
+شركات و أشخاص من الشباب اللي يستخدمون الكثير من
+
+210
+00:14:52,360 --> 00:14:56,240
+المال انت مالك اتون اتون مليون اتون مليون باونز و
+
+211
+00:14:56,240 --> 00:14:58,280
+بعد ذلك لديك 15 مالين مالين مالين مالين مالين
+
+212
+00:14:58,280 --> 00:14:58,960
+مالين مالين مالين مالين مالين مالين مالين مالين
+
+213
+00:14:58,960 --> 00:14:59,360
+مالين مالين مالين مالين مالين مالين مالين مالين
+
+214
+00:14:59,360 --> 00:15:00,310
+مالين مالين مالين مالين مالين مالين مالين مالين مو
+
+215
+00:15:00,310 --> 00:15:04,170
+كل يوم انت في الحكمة تتجارب عليهم و تقول انهم
+
+216
+00:15:04,170 --> 00:15:07,250
+يطلبون منك أن تدفع المال و لا يمكنك أن تدفع المال،
+
+217
+00:15:07,250 --> 00:15:11,070
+ربما تكون في حجة، ماذا يجب أن تفعل؟ و فجأة تجد
+
+218
+00:15:11,070 --> 00:15:17,810
+حلوة، حلوة مجنونة، حلوة مجنونة تقول هنا بإن فجأة
+
+219
+00:15:17,810 --> 00:15:19,930
+يمكنك أن تكون مرحب، لا أحد يمكنه أن يطلب منك أي
+
+220
+00:15:19,930 --> 00:15:25,420
+شيء، هذا يعني إيقاف، إيقافthat we have the first
+
+221
+00:15:25,420 --> 00:15:27,680
+time and the second and the first time you can be
+
+222
+00:15:27,680 --> 00:15:30,220
+free no one can ask you for some people
+
+223
+00:15:30,220 --> 00:15:35,380
+liquidation is a solution it's good for some
+
+224
+00:15:35,380 --> 00:15:38,400
+people it's not it's bad thing because liquidation
+
+225
+00:15:38,400 --> 00:15:43,480
+it means an execution اعدام execution for the
+
+226
+00:15:43,480 --> 00:15:48,410
+person whether going to be a natural person orفتشة
+
+227
+00:15:48,410 --> 00:15:51,530
+person company or human being it's execution
+
+228
+00:15:51,530 --> 00:15:55,690
+because this is the end of the life that's it done
+
+229
+00:15:55,690 --> 00:15:58,950
+close the business take your money you will be
+
+230
+00:15:58,950 --> 00:16:02,010
+frozen stopped you cannot work anymore in the
+
+231
+00:16:02,010 --> 00:16:06,190
+market even if you have a discharge VFA and you
+
+232
+00:16:06,190 --> 00:16:10,070
+haveفي المستقبل إذا كنت ترغب في العودة لشركة لأنك
+
+233
+00:16:10,070 --> 00:16:12,650
+قد تعود لشركة في المستقبل إذا كنت ترغب في العودة
+
+234
+00:16:12,650 --> 00:16:14,990
+لشركة في المستقبل في المستقبل في المستقبل في
+
+235
+00:16:14,990 --> 00:16:17,730
+المستقبل في المستقبل في المستقبل في المستقبل في
+
+236
+00:16:17,730 --> 00:16:17,790
+المستقبل في المستقبل في المستقبل في المستقبل في
+
+237
+00:16:17,790 --> 00:16:18,330
+المستقبل في المستقبل في المستقبل في المستقبل في
+
+238
+00:16:18,330 --> 00:16:18,730
+المستقبل في المستقبل في المستقبل في المستقبل في
+
+239
+00:16:18,730 --> 00:16:22,310
+المستقبل في المستقبل في المستقبل في المستقبل في
+
+240
+00:16:22,310 --> 00:16:26,790
+المستقبل في المستقبل في المستقبل في المستقبل في
+
+241
+00:16:26,790 --> 00:16:28,870
+المستقبل في المستقبل في المستقبل في المستقبل في
+
+242
+00:16:28,870 --> 00:16:34,620
+المستقبل في المستقبل في المستقبلI did not be .. I
+
+243
+00:16:34,620 --> 00:16:37,600
+was free .. by the way in Islam there is no
+
+244
+00:16:37,600 --> 00:16:41,100
+bankruptcy .. no bankruptcy .. because in Islam if
+
+245
+00:16:41,100 --> 00:16:43,500
+you are in debt you have to be in the debts ..
+
+246
+00:16:43,500 --> 00:16:46,480
+even once .. even after you pass away .. after you
+
+247
+00:16:46,480 --> 00:16:50,110
+die .. your inheritance will have to be thereبسبب
+
+248
+00:16:50,110 --> 00:16:54,450
+أن كل شيء سيكون مغفر باستثناء المقابلين، ولكن هذا
+
+249
+00:16:54,450 --> 00:16:58,430
+قانون مجنون، حتى في بلستان اليوم، لدينا نفس الوضع،
+
+250
+00:16:58,430 --> 00:17:01,750
+قانون مجنون، لدينا مغامرة، و لدينا بعض الحالات في
+
+251
+00:17:01,750 --> 00:17:04,510
+غزا هنا، في التي لدينا بعض الناس اللي طلبوا
+
+252
+00:17:04,510 --> 00:17:07,670
+المغامرة، لأنها كانت الوحيدة الموجودة لهم، لا
+
+253
+00:17:07,670 --> 00:17:10,570
+يمكنوا أن يدفعوا المقابلين، ولكن إذا أردوا في
+
+254
+00:17:10,570 --> 00:17:13,650
+المستقبل أن يدفعوا المقابلين، حتى لو كانوا لديهم
+
+255
+00:17:13,650 --> 00:17:16,230
+حرية، فهي مقبلة لهم، ولكن لا أحد يستطيع أن يضطر
+
+256
+00:17:17,340 --> 00:17:23,140
+الدتر اللي يصبح مغامر، الدتر يصبح مغامر، لا أحد
+
+257
+00:17:23,140 --> 00:17:27,860
+يستطيع أن يجعله يكون أي شيء، خارج، خارج، ولا حد
+
+258
+00:17:27,860 --> 00:17:33,740
+بيساعده، هذا حياة جديدة، تخيل، هذا ليس شيء مقبول
+
+259
+00:17:33,740 --> 00:17:37,400
+في مجتمعنا، أليس كذلك؟ ماذا يمكنك أن تفعل؟ مثلًا،
+
+260
+00:17:37,400 --> 00:17:42,220
+إذا أعطيت شخص 10 ألف دينا أو 20 ألف دينا،
+
+261
+00:17:46,300 --> 00:17:51,040
+you might take drastic actions in society here
+
+262
+00:17:51,040 --> 00:17:54,360
+which people don't believe in bankruptcy because
+
+263
+00:17:54,360 --> 00:17:57,400
+they spend their life making money and suddenly
+
+264
+00:17:57,400 --> 00:17:59,740
+somebody take your money and get away with that
+
+265
+00:17:59,740 --> 00:18:05,020
+but this system of bankruptcy is made for honest
+
+266
+00:18:05,020 --> 00:18:10,660
+honest you might lose you might win say well
+
+267
+00:18:10,660 --> 00:18:14,160
+somebody isn't dead and he or she has no money
+
+268
+00:18:14,160 --> 00:18:18,790
+what can we doهل سيبقى في الحياة بقية حياته في
+
+269
+00:18:18,790 --> 00:18:23,970
+الحجر؟ هذا لن يخلق اي اختلاف لك و لا يخلق اي
+
+270
+00:18:23,970 --> 00:18:27,270
+اختلاف لأحد اذا كان في الحجر او في المنزل او
+
+271
+00:18:27,270 --> 00:18:31,530
+بمفرده لن يبقى .. لن يبقى على أي حال لأنه لن يحصل
+
+272
+00:18:31,530 --> 00:18:34,350
+على المال لكن اذا كان او انها بمفرده يمكن أن
+
+273
+00:18:34,350 --> 00:18:37,910
+يعملوا و يكونوا مجانين في المستقبل بس احنا عايزين
+
+274
+00:18:37,910 --> 00:18:42,930
+نبسوا يعنى؟ لا بس بانكرابسي اذا اناس بانكرابسي
+
+275
+00:18:42,930 --> 00:18:45,850
+خلاص you can't ask you can't ask nothing
+
+276
+00:18:55,330 --> 00:18:59,050
+التعذيب هو توقف عن العمل في مجتمعك ستشاهد ..
+
+277
+00:18:59,050 --> 00:19:03,250
+ستشاهد لاحقًا أننا لدينا بعض المفاجأة أو الانفجار،
+
+278
+00:19:03,250 --> 00:19:06,570
+ماذا سيحدث لهذا الشخص؟ نحن لدينا الكثير من النقطة،
+
+279
+00:19:06,570 --> 00:19:10,190
+ماذا سيحدث لك بشكل عام في المجتمع إذا أصبحت
+
+280
+00:19:10,190 --> 00:19:14,870
+انفجار؟ إنه ليس بسهولة، إنه مضغوط، مثل وصمة، ضد
+
+281
+00:19:14,870 --> 00:19:19,350
+ذلك الشخص، شخص .. أحيانًا الناس مثل هذا لا يخرج
+
+282
+00:19:19,350 --> 00:19:23,230
+حتى في الشوارع لتتحدث مع الناس لأنهم يشعرون بالخوف
+
+283
+00:19:24,440 --> 00:19:27,460
+They lost their dignity، they lost their honesty،
+
+284
+00:19:27,460 --> 00:19:31,380
+they can't talk to people anymore. There is
+
+285
+00:19:31,380 --> 00:19:33,280
+something I want to mention before talking about
+
+286
+00:19:33,280 --> 00:19:36,660
+bankruptcy in the states. We have something called
+
+287
+00:19:36,660 --> 00:19:41,180
+bankruptcy fraud. We have a number of people who
+
+288
+00:19:41,180 --> 00:19:44,120
+are applying for bankruptcy. In fact, they are not
+
+289
+00:19:44,120 --> 00:19:48,210
+bankrupted.في الحقيقة هم ليسوا مغامرين، إذا كنت
+
+290
+00:19:48,210 --> 00:19:53,550
+تبحث في جوجل، إذا كنت تفتح جوجل و تبحث، ستجد ألف
+
+291
+00:19:53,550 --> 00:19:58,630
+شركة مغامرة كل عام، ألف، في أوروبا، حتى ألف ألف
+
+292
+00:19:58,630 --> 00:20:02,370
+شركات، ستجد الكثير من الشخصيات، أنا أعرف، لقد رأيت
+
+293
+00:20:02,370 --> 00:20:04,110
+الكثير من الأمثلة مثل هذه عندما كنت في الولايات
+
+294
+00:20:04,110 --> 00:20:07,410
+المتحدة، الناس اللي طلبوا المغامرة، على الرغم من
+
+295
+00:20:07,410 --> 00:20:10,450
+الحقيقة أن بعضهم كانوا مخاطرين، مخاطرين، يمكنهم أن
+
+296
+00:20:10,450 --> 00:20:15,200
+يختبئوا المال في مكان ما، ويقولون، نحن فاترينالأن،
+
+297
+00:20:15,200 --> 00:20:19,160
+كيف نتعامل مع حالة مثل هذه؟ إذا لم يكن هناك تجارب،
+
+298
+00:20:19,160 --> 00:20:24,720
+إذا قمنا بتأكيد أن هذه الشخصة كانت تخاطب الحكومة و
+
+299
+00:20:24,720 --> 00:20:29,100
+كان لديه المال و كان يخلقه و لم يتبع نظام القانون،
+
+300
+00:20:29,100 --> 00:20:33,680
+فلن يكون هناك تجارب، لن يكون مغفر، لن يكون غير
+
+301
+00:20:33,680 --> 00:20:38,540
+مسؤول، فعلينا أن نتبعه حتى نحصل على المال، لكن
+
+302
+00:20:38,540 --> 00:20:41,390
+المشكلة هي أنها ليست أسهل لكي نثبت عليهابسبب أن
+
+303
+00:20:41,390 --> 00:20:44,790
+بعض الناس الصحيحة .. بعض الناس الصحيحة يستطيعون أن
+
+304
+00:20:44,790 --> 00:20:47,870
+يخرجوا من المال .. يعرفون أن بعض الناس تعمل الشركة
+
+305
+00:20:47,870 --> 00:20:50,910
+.. تفتح الشركات .. يحصلوا على بعض الدفعات من
+
+306
+00:20:50,910 --> 00:20:55,270
+الشركات .. ملايين أو باون .. ملايين .. و يتوقفوا
+
+307
+00:20:55,270 --> 00:20:57,490
+.. يفتحوا الشركة لأحد أو اثنين سنة .. و بعد ذلك
+
+308
+00:20:57,490 --> 00:21:01,590
+يقوموا بالتخلص .. مثل ذلك .. يختبئوا المال مع شخص
+
+309
+00:21:01,590 --> 00:21:05,910
+آخر .. و ليس لديهم أي شيء في إسمهم .. لا شيء .. و
+
+310
+00:21:05,910 --> 00:21:06,830
+يحاولون أن يفقدوا ..
+
+311
+00:21:10,750 --> 00:21:15,550
+then بستفيدوا or they get the money or they don't
+
+312
+00:21:15,550 --> 00:21:20,790
+care about it they don't care about reputation so
+
+313
+00:21:20,790 --> 00:21:23,670
+those are type of people we have them we have such
+
+314
+00:21:23,670 --> 00:21:28,550
+people such people but if we can prove that this
+
+315
+00:21:28,550 --> 00:21:31,910
+person was not honest the bankrupt was not honest
+
+316
+00:21:31,910 --> 00:21:35,990
+then he will not get it will not be forgiven he
+
+317
+00:21:35,990 --> 00:21:39,340
+will not be this situation he can he should beالان
+
+318
+00:21:39,340 --> 00:21:41,620
+يجب أن نتحرك إلى الانفجار في الولايات المتحدة،
+
+319
+00:21:41,620 --> 00:21:45,620
+ببعض الصفحات الولايات
+
+320
+00:21:45,620 --> 00:21:50,960
+المتحدة مثل بلد أخرى، لديها قانونها الخاصة، وهو
+
+321
+00:21:50,960 --> 00:21:54,060
+اسمها الانفجار، انت تعرفين أننا في الولايات لدينا،
+
+322
+00:21:54,060 --> 00:22:02,300
+لدينا خمسين او اتس، كل شرطة، كل شرطة لها قانونها
+
+323
+00:22:02,300 --> 00:22:10,190
+الخاصة، كل شرطة لها قانونها الخاصةصانعي القانون
+
+324
+00:22:10,190 --> 00:22:14,230
+but sometimes we have some important issues in
+
+325
+00:22:14,230 --> 00:22:17,710
+which we have to deal with them by the congress
+
+326
+00:22:17,710 --> 00:22:24,250
+here on the federal jurisdictions the most
+
+327
+00:22:24,250 --> 00:22:26,990
+important issues at all which concerning the whole
+
+328
+00:22:26,990 --> 00:22:32,640
+united states can beيمكن أن يتم إدارته من الكونغرس
+
+329
+00:22:32,640 --> 00:22:37,480
+على مستوى فدرال، مستوى فدرال، نظام فدرالي، وهو
+
+330
+00:22:37,480 --> 00:22:40,700
+مستوى الولايات المتحدة عامة، واحدة منها هي
+
+331
+00:22:40,700 --> 00:22:44,620
+الانفجار، الانفجار في الولايات المتحدة هي موقع
+
+332
+00:22:44,620 --> 00:22:49,220
+كبير تحت مستوى فدرال، فهو فقط واحد قانون لكل
+
+333
+00:22:49,220 --> 00:22:52,380
+مستوى، ليس كل مستوى، مثلا إذا أردنا لدينا قانون
+
+334
+00:22:52,380 --> 00:22:58,270
+عالمي، قانون مجتمعيتاكس، يمكنك أن تكون هناك أشياء
+
+335
+00:22:58,270 --> 00:23:02,230
+تتميزها في كل شرطة، ولكن عندما يتعلق بالانفجار،
+
+336
+00:23:02,230 --> 00:23:04,610
+حتى إذا كانت جزء من القواعد التجارية، لكن الانفجار
+
+337
+00:23:04,610 --> 00:23:08,050
+يتم تنظيمه تحت مجموعة فدرالية، مجموعة فدرالية،
+
+338
+00:23:08,050 --> 00:23:08,930
+مجموعة فدرالية، مجموعة فدرالية، مجموعة فدرالية،
+
+339
+00:23:08,930 --> 00:23:10,150
+مجموعة فدرالية، مجموعة فدرالية، مجموعة فدرالية،
+
+340
+00:23:10,150 --> 00:23:12,590
+مجموعة فدرالية، مجموعة فدرالية، مجموعة فدرالية،
+
+341
+00:23:12,590 --> 00:23:15,970
+مجموعة
+
+342
+00:23:15,970 --> 00:23:20,730
+فدرالية، مجموعة
+
+343
+00:23:20,730 --> 00:23:27,570
+فدرالية، مجموعةهذا الموضوع يؤثر على نوع ال .. نوع
+
+344
+00:23:27,570 --> 00:23:29,290
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+345
+00:23:29,290 --> 00:23:29,730
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+346
+00:23:29,730 --> 00:23:30,310
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+347
+00:23:30,310 --> 00:23:34,170
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+348
+00:23:34,170 --> 00:23:35,510
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+349
+00:23:35,510 --> 00:23:35,530
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+350
+00:23:35,530 --> 00:23:36,110
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+351
+00:23:36,110 --> 00:23:38,190
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+352
+00:23:38,190 --> 00:23:41,650
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+353
+00:23:41,650 --> 00:23:46,210
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+354
+00:23:46,210 --> 00:23:52,670
+ال .. نوع ال .. نوع
+
+355
+00:23:56,560 --> 00:23:59,100
+Bankruptcy is something affect the whole society.
+
+356
+00:24:00,360 --> 00:24:02,080
+We are not talking about small companies. We are
+
+357
+00:24:02,080 --> 00:24:05,360
+talking about big companies, corporations. Some of
+
+358
+00:24:05,360 --> 00:24:09,680
+them invest billions, billions of dollars. Some of
+
+359
+00:24:09,680 --> 00:24:14,700
+them, some of those companies employ tens of
+
+360
+00:24:14,700 --> 00:24:16,780
+thousands of people. Imagine one company having
+
+361
+00:24:16,780 --> 00:24:20,640
+300,000 employees. What would happen to this
+
+362
+00:24:20,640 --> 00:24:23,920
+company if it's bankrupted? What would happen to
+
+363
+00:24:23,920 --> 00:24:28,240
+the state economy?شركة واحدة تكون لديها 50 ألف
+
+364
+00:24:28,240 --> 00:24:33,000
+موظف، 50، تخيل أن 50 ألف موظف اليوم يجلسون في
+
+365
+00:24:33,000 --> 00:24:35,800
+المنزل، ليس لديهم إيجار، ماذا سيحدث؟ في إحدى أو
+
+366
+00:24:35,800 --> 00:24:38,680
+إتين إمارات؟ هذا سيؤثر على إقتصاد الولايات
+
+367
+00:24:38,680 --> 00:24:41,880
+المتحدة، ثم يجب أن يكون الحكومة الولايات المتحدة
+
+368
+00:24:41,880 --> 00:24:45,660
+تدفع تلك الناس لإنقاذهم، يجب أن تدفع تدفع تدفع
+
+369
+00:24:45,660 --> 00:24:47,200
+تدفع تدفع تدفع تدفع تدفع تدفع تدفع تدفع تدفع تدفع
+
+370
+00:24:47,200 --> 00:24:50,880
+تدفع تدفع تدفع تدفع تدفع تدفع تدفع تدفع تدفع ت
+
+371
+00:24:51,430 --> 00:24:55,330
+هو مصطلح مصطلح مصطلح الولايات. واحد من الأشياء
+
+372
+00:24:55,330 --> 00:24:57,110
+الرئيسية في النظام الاقتصادي في الولايات هي
+
+373
+00:24:57,110 --> 00:25:01,030
+القانون التجاربي. القانون التجاربي يجب أن يكون
+
+374
+00:25:01,030 --> 00:25:05,570
+مصطلح في أعلى مستوى في الواقع يجب أن نحمي المجتمع.
+
+375
+00:25:06,170 --> 00:25:09,950
+لا نريد اي شركة فقط في أي وقت، يا عزيزي، نطلب فقط
+
+376
+00:25:09,950 --> 00:25:14,190
+تجارب. لا، عليك أن تكون مسؤول عن هذا. نحن نعمل هنا
+
+377
+00:25:14,190 --> 00:25:19,110
+قرارات صعبةونجعل الاختصارات مرتبطة باختصارات
+
+378
+00:25:19,110 --> 00:25:19,170
+مرتبطة باختصارات مرتبطة باختصارات مرتبطة باختصارات
+
+379
+00:25:19,170 --> 00:25:22,810
+مرتبطة باختصارات مرتبطة باختصارات مرتبطة باختصارات
+
+380
+00:25:22,810 --> 00:25:25,790
+مرتبطة باختصارات مرتبطة باختصارات مرتبطة باختصارات
+
+381
+00:25:25,790 --> 00:25:26,350
+مرتبطة باختصارات مرتبطة باختصارات مرتبطة باختصارات
+
+382
+00:25:26,350 --> 00:25:26,610
+مرتبطة باختصارات مرتبطة باختصارات مرتبطة باختصارات
+
+383
+00:25:26,610 --> 00:25:45,190
+مرتبطة باختصارات مرتبطة باختصارات مرتبطة باختصارات
+
+384
+00:25:45,190 --> 00:25:54,190
+مرتبطةانت تحتاج اكتشاف اكتشاف انت
+
+385
+00:25:54,190 --> 00:26:03,470
+تحتاج اكتشاف انت تحتاج اكتشاف انت
+
+386
+00:26:03,470 --> 00:26:04,310
+تحتاج اكتشاف انت تحتاج اكتشاف انت تحتاج اكتشاف انت
+
+387
+00:26:04,310 --> 00:26:04,730
+تحتاج اكتشاف انت تحتاج اكتشاف انت تحتاج اكتشاف انت
+
+388
+00:26:04,730 --> 00:26:05,310
+تحتاج اكتشاف انت تحتاج اكتشاف انت تحتاج اكتشاف انت
+
+389
+00:26:05,310 --> 00:26:05,530
+تحتاج اكتشاف انت تحتاج اكتشاف انت تحتاج اكتشاف انت
+
+390
+00:26:05,530 --> 00:26:07,490
+تحتاج اكتشاف انت تحتاج اكتشاف انت تحتاج اكتشاف انت
+
+391
+00:26:07,490 --> 00:26:16,090
+تحتاج اكتشاف انت تحتاج اكتشاف انت تحتاج اكتشاف انت
+
+392
+00:26:16,090 --> 00:26:18,360
+تحتاج اكتشالنسبة للانفجار في جميع الولايات
+
+393
+00:26:18,360 --> 00:26:22,220
+المتحدة، في جميع الولايات المتحدة، لكن، حسنا، يجب
+
+394
+00:26:22,220 --> 00:26:24,860
+أن نطلق القانون الانفجاري، اللي مجرد مجتمع
+
+395
+00:26:24,860 --> 00:26:28,960
+الانفجار، ولكن يجب أن نطلقه في كل شرطة، أليس كذلك؟
+
+396
+00:26:28,960 --> 00:26:33,140
+هل تعتقد أن في كل شرطة لديها نفس الوضع؟ ليس كذلك،
+
+397
+00:26:33,140 --> 00:26:36,820
+كل شرطة لديها قانون مخصص، قانون مخصص، قانون مخصص،
+
+398
+00:26:36,820 --> 00:26:38,260
+قانون مخصص، قانون مخصص، قانون مخصص، قانون مخصص،
+
+399
+00:26:38,260 --> 00:26:43,720
+قانون مخصص، قانون مخصص، قانون مخصص، قانون مخصص،ثم
+
+400
+00:26:43,720 --> 00:26:49,580
+نأخذ قانون الانفجار في كل مصطلح، في كل مصطلح،
+
+401
+00:26:49,580 --> 00:26:54,360
+نستطيع تأكيده، ليس تأكيده كتغيير، بل نستطيع تأكيده
+
+402
+00:26:54,360 --> 00:26:59,140
+لكي يكون مناسب لكل مصطلح، لكن في نفس الوقت، ليس
+
+403
+00:26:59,140 --> 00:27:05,300
+ليه يؤثر على قانون الانفجار، هي مثل تأكيدها، لكن
+
+404
+00:27:05,300 --> 00:27:07,700
+تأكيدها، هل أحد يقدر يقرأها؟
+
+405
+00:27:16,560 --> 00:27:20,760
+القانون القانون مقاومة بشكل عام بشكل عام بشكل عام
+
+406
+00:27:20,760 --> 00:27:22,200
+بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل
+
+407
+00:27:22,200 --> 00:27:24,540
+عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام
+
+408
+00:27:24,540 --> 00:27:26,140
+بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل
+
+409
+00:27:26,140 --> 00:27:26,160
+عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام
+
+410
+00:27:26,160 --> 00:27:26,300
+عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام
+
+411
+00:27:26,300 --> 00:27:31,200
+بشكل عام بشكل عام بشكل عام بشكل
+
+412
+00:27:31,200 --> 00:27:39,380
+عام بشكل عام بشكل عام بش
+
+413
+00:27:42,300 --> 00:27:45,480
+بالنسبة ليس مع تغيير القواعد ولكن لدينا بعض
+
+414
+00:27:45,480 --> 00:27:48,300
+الاعتبارات التي يمكننا استخدام القواعد الانفجارية
+
+415
+00:27:48,300 --> 00:27:52,060
+ولكن يمكننا استخدام احتاجاتنا احتاجاتنا في كل
+
+416
+00:27:52,060 --> 00:27:55,160
+مجتمع وفي كل مدينة لأن إذا تنظر إلى الشمال والشرق
+
+417
+00:27:55,160 --> 00:27:58,480
+في المدينة ليسوا على نفس المستوى في الشمال هم
+
+418
+00:27:58,480 --> 00:28:02,200
+عارفين وفي الشرق هم فارغين في بعض المدن تكون لديك
+
+419
+00:28:02,200 --> 00:28:04,580
+الكثير من التجارب لكي تكون مدفن في أخر مدن لم تكن
+
+420
+00:28:04,580 --> 00:28:07,200
+لديك كثير من التجارب لأنك تريد أن تجعل الناس
+
+421
+00:28:07,200 --> 00:28:09,240
+يستخدمون المال
+
+422
+00:28:12,260 --> 00:28:17,680
+الان في الولايات لدينا بنكروبسي بنكروبسي الواقع
+
+423
+00:28:17,680 --> 00:28:22,540
+يتم تحويله إلى اتصال اتصال اتصال اتصال اتصال اتصال
+
+424
+00:28:22,540 --> 00:28:26,380
+اتصال اتصال اتصال اتصال اتصال اتصال
+
+425
+00:28:26,380 --> 00:28:26,560
+اتصال اتصال اتصال اتصال اتصال اتصال اتصال اتصال
+
+426
+00:28:26,560 --> 00:28:26,940
+اتصال اتصال اتصال اتصال اتصال اتصال اتصال اتصال
+
+427
+00:28:26,940 --> 00:28:27,040
+اتصال اتصال اتصال اتصال اتصال اتصال اتصال اتصال
+
+428
+00:28:27,040 --> 00:28:27,900
+اتصال اتصال اتصال
+
+429
+00:28:46,590 --> 00:28:52,830
+او ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او
+
+430
+00:28:52,830 --> 00:28:52,990
+ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او
+
+431
+00:28:52,990 --> 00:28:54,370
+ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او
+
+432
+00:28:54,370 --> 00:29:06,290
+ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او
+
+433
+00:29:06,290 --> 00:29:12,250
+ايه؟ اوas a debtor why should we sell and we
+
+434
+00:29:12,250 --> 00:29:14,950
+divide because in return you have to have the
+
+435
+00:29:14,950 --> 00:29:19,170
+freedom this charge in exchange the debtor is
+
+436
+00:29:19,170 --> 00:29:25,750
+entitled to a discharge بمعنى الاعفاء that's it
+
+437
+00:29:25,750 --> 00:29:29,250
+اعفاء the freedom we have we have the freedom we
+
+438
+00:29:29,250 --> 00:29:31,490
+have the discharge for that person what do you
+
+439
+00:29:31,490 --> 00:29:33,310
+think there's something here we have to keep in
+
+440
+00:29:33,310 --> 00:29:35,230
+our minds someone
+
+441
+00:29:37,040 --> 00:29:42,620
+الشخص كان عالق و أخذنا كل ما كان لديه و أخذنا بعض
+
+442
+00:29:42,620 --> 00:29:50,100
+المال و قليل من المال منه و عائلته لننجو و أخذنا
+
+443
+00:29:50,100 --> 00:29:57,080
+المال
+
+444
+00:29:57,080 --> 00:30:02,820
+و أخذنا المال و أخذنا
+
+445
+00:30:02,820 --> 00:30:02,880
+المال و أخذنا المال و أخذنا المال و أخذنا المال و
+
+446
+00:30:02,880 --> 00:30:02,920
+أخذنا المال و أخذنا المال و أخذنا المال و أخذنا
+
+447
+00:30:02,920 --> 00:30:05,380
+المال و أخذنا المال و أالإنسان هو الكنيسة والحرية
+
+448
+00:30:05,380 --> 00:30:09,900
+ولكن نحن لدينا بعض الاعتبارات، اسمع هذا بطيئة، نحن
+
+449
+00:30:09,900 --> 00:30:15,700
+لدينا بعض الاعتبارات، نحن نغفر الناس مثل دوس، نحن
+
+450
+00:30:15,700 --> 00:30:18,680
+لن نطلب منهم في المستقبل لأي شيء، ولكن نفعل ذلك
+
+451
+00:30:18,680 --> 00:30:22,530
+أحياناWe do have some exceptions in which you
+
+452
+00:30:22,530 --> 00:30:25,590
+would have to pay the money even if it takes 50
+
+453
+00:30:25,590 --> 00:30:28,630
+years, even if it takes the end of your life as a
+
+454
+00:30:28,630 --> 00:30:30,990
+debtor, you would have to pay the money. We have
+
+455
+00:30:30,990 --> 00:30:34,130
+two examples like for example here, a discharge
+
+456
+00:30:34,130 --> 00:30:37,910
+will not be applicable in those two cases. Can you
+
+457
+00:30:37,910 --> 00:30:38,170
+read it?
+
+458
+00:30:44,690 --> 00:30:56,510
+مضنب يعني مضنب مضنب
+
+459
+00:30:56,510 --> 00:31:03,020
+مضنب مضنب مضنبفي حالة اقتصادية هنا حتى في حالة
+
+460
+00:31:03,020 --> 00:31:07,100
+اقتصادية مرتبطة بشكل أكتر لأن إذا قمت بإخفاء شيء
+
+461
+00:31:07,100 --> 00:31:10,760
+إذا قمت بإخفاء المال إذا قمت بإخفاء حسابات الحكومة
+
+462
+00:31:10,760 --> 00:31:17,340
+إذا قمت بإبقاء حساباتك بعيدا من المؤمنين في جميع
+
+463
+00:31:17,340 --> 00:31:21,760
+الحالات هنا لن تكون في هذه الحالة علينا أن نتبع
+
+464
+00:31:21,760 --> 00:31:26,000
+ذلك الشخص مرة أخرى و مرة أخرى حتى يدفع رقم 2
+
+465
+00:31:35,840 --> 00:31:39,180
+even if you are discharged there are some debts
+
+466
+00:31:39,180 --> 00:31:42,840
+you will not be like some of them some of those
+
+467
+00:31:42,840 --> 00:31:45,100
+are connected with the public policy public
+
+468
+00:31:45,100 --> 00:31:49,960
+interest like the tax tax tax is not personal debt
+
+469
+00:31:49,960 --> 00:31:53,780
+isn't it it's not personal tax is for the state
+
+470
+00:31:54,790 --> 00:31:56,790
+then you have to pay it for the government, it's
+
+471
+00:31:56,790 --> 00:32:01,270
+not for personal debt. In addition to spousal
+
+472
+00:32:01,270 --> 00:32:06,170
+support, spousal like the wife, his wife and he's
+
+473
+00:32:06,170 --> 00:32:09,070
+supposed to be because how can she live, how can
+
+474
+00:32:09,070 --> 00:32:11,690
+she survive, his children, that's what we call
+
+475
+00:32:11,690 --> 00:32:15,870
+spousal supportالمال يجب أن يكون مدفع لأننا نتكلم
+
+476
+00:32:15,870 --> 00:32:20,270
+هنا عن الحياة، المشكلة بالحياة، الانتصار الواضح في
+
+477
+00:32:20,270 --> 00:32:24,330
+تلك الحالات، هؤلاء هم إمثالين، أعني، يمكن الحرس أن
+
+478
+00:32:24,330 --> 00:32:28,770
+يجد طريقات لإيقاف حالة فيها في بعض الأحيان، في بعض
+
+479
+00:32:28,770 --> 00:32:33,990
+الأحيان، لن نكون قادرين على إخلاء الـBankrupt في
+
+480
+00:32:33,990 --> 00:32:38,050
+بعض الحالات هل يكون هناك تجارب مثل التجارب
+
+481
+00:32:38,050 --> 00:32:43,760
+والتجارب لأنها تم تجاربها؟بقى دي mean بقى دي
+
+482
+00:32:43,760 --> 00:32:47,340
+مابتاخد انه مابتنعرفها ان قولت انه some taxes
+
+483
+00:32:47,340 --> 00:32:52,060
+doesn't have this charge about it because it's
+
+484
+00:32:52,060 --> 00:32:57,300
+before it's exempted صح؟ it's not exempted the tax
+
+485
+00:32:57,300 --> 00:33:01,180
+it's not؟ في عنها exemptions و deductionsفي
+
+486
+00:33:01,180 --> 00:33:03,720
+reduction sometimes it's not .. I mean the tax it
+
+487
+00:33:03,720 --> 00:33:08,340
+was .. it was not personal right it was the state
+
+488
+00:33:08,340 --> 00:33:10,460
+it was for the state and it's supposed to be for
+
+489
+00:33:10,460 --> 00:33:15,980
+the state and even .. the tax .. we pay the tax
+
+490
+00:33:15,980 --> 00:33:19,040
+for the state or not .. tax office .. we pay the
+
+491
+00:33:19,040 --> 00:33:22,200
+tax for the tax office and like people who did not
+
+492
+00:33:22,200 --> 00:33:25,000
+pay the tax for a while of time and then we
+
+493
+00:33:25,000 --> 00:33:27,260
+discover this they have to pay it .. they will
+
+494
+00:33:27,260 --> 00:33:27,900
+have to pay it
+
+495
+00:33:31,360 --> 00:33:36,040
+شخص ما أسألني قبل وقت ما اتسأل اذا الانتجار ليس
+
+496
+00:33:36,040 --> 00:33:39,440
+لديه أي شيء على الإطلاق، ماذا نفعل؟ ليس لديه أي
+
+497
+00:33:39,440 --> 00:33:46,300
+شيء، انتجار ليس لديه أي شيء، ماذا نفعل؟ انتجار ليس
+
+498
+00:33:46,300 --> 00:33:53,380
+لديه أي شيء، ماذا نفعل؟ انتجار ليس لديه أي شيء،
+
+499
+00:33:53,380 --> 00:33:57,680
+ماذا نفعل؟ انتجار ليس لديه أي شيء، ماذا نفعل؟ ماذا
+
+500
+00:33:57,680 --> 00:33:57,780
+نفعل؟ ماذا نفعل؟ ماذا نفعل؟ ماذا نفعل؟ ماذا نفعل؟
+
+501
+00:33:57,780 --> 00:33:57,840
+ماذا نفعل؟ ماذا نفعل؟ ماذا نفعل؟ ماذا نفعل؟ ماذا
+
+502
+00:33:57,840 --> 00:34:00,940
+نفعل؟ ماذا نفعل؟ ماذا نفعل؟ ماذا نالسيارات
+
+503
+00:34:00,940 --> 00:34:05,700
+القديمة، أشياء مثل هذه مخرجة هل سنأخذه منه أو
+
+504
+00:34:05,700 --> 00:34:15,100
+سنبقى بيهم؟ البرج يعطي هذا الشخص شيء يجعله يبقى
+
+505
+00:34:15,100 --> 00:34:17,140
+حياة في هذا البرج ليس مثلًا إنه ليس لديه أي شيء
+
+506
+00:34:17,140 --> 00:34:21,780
+إلا إذا كان مخرج من البرج لا يمكننا أن نأخذه
+
+507
+00:34:21,780 --> 00:34:34,880
+بالطبع هل أنت متأكدة؟ نعمإذا كانت المالك تتعلق
+
+508
+00:34:34,880 --> 00:34:39,900
+بالمالك، هل ستغفر هذا الشخص؟ لا، لن نتعامل مع
+
+509
+00:34:39,900 --> 00:34:46,320
+بعضنا البعض في الولايات المتحدة، يقول، نحن لدينا
+
+510
+00:34:46,320 --> 00:34:51,700
+شيء يسمى بالإنقاذ، يعني نفس الشيء، إنه تجارب كبير،
+
+511
+00:34:51,700 --> 00:34:55,260
+كم عادة يستطيع شخص ما يستخدمها للإنقاذ؟ كم عادة
+
+512
+00:34:55,260 --> 00:34:58,330
+يستطيع شخص ما يستطيع استخدامها للإنقاذ؟اليوم،
+
+513
+00:34:58,330 --> 00:35:01,390
+اليوم، لدينا مغامرة، هل نستعمل مرة أخرى في
+
+514
+00:35:01,390 --> 00:35:08,450
+المستقبل؟ نعم، في بعض الأيام، نعم، في بعض الأيام،
+
+515
+00:35:08,450 --> 00:35:08,730
+نعم، في بعض الأيام، نعم، نعم، نعم، نعم، نعم، نعم،
+
+516
+00:35:08,730 --> 00:35:08,830
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+517
+00:35:08,830 --> 00:35:08,850
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+518
+00:35:08,850 --> 00:35:11,410
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+519
+00:35:11,410 --> 00:35:14,470
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+520
+00:35:18,950 --> 00:35:22,030
+ثم تتعامل مع نفس الموضوع، هل يمكنك أن تطلع
+
+521
+00:35:22,030 --> 00:35:26,010
+للتجارة؟ نعم، في الولايات المتحدة، يقول إنه يمكنك
+
+522
+00:35:26,010 --> 00:35:31,570
+أن تطلع للتجارة كل 8 سنة، على الأقل، على الأقل،
+
+523
+00:35:31,570 --> 00:35:35,270
+عليك أن تكون بين الأول والثاني التجارة 8 سنة، 8
+
+524
+00:35:35,270 --> 00:35:38,410
+سنة، 8 سنة، 8 سنة، 8 سنة، 8 سنة، 8 سنة، 8 سنة، 8
+
+525
+00:35:38,410 --> 00:35:39,130
+سنة، 8 سنة، 8 سنة، 8 سنة، 8 سنة، 8 سنة، 8 سنة، 8
+
+526
+00:35:39,130 --> 00:35:42,770
+سنة، 8 سنة، 8 سنة، 8 سنة، 8 سنة، 8 سنة، 8 سنة، 8
+
+527
+00:35:42,770 --> 00:35:51,210
+سنة، 8 سنة، 8 سنة، 8 سنة، 8العامين يجب ان ينتظر 8
+
+528
+00:35:51,210 --> 00:35:53,870
+سنة من هناك و من هناك و من هناك و من هناك و من
+
+529
+00:35:53,870 --> 00:35:55,510
+هناك و من هناك و من هناك و من هناك و من هناك و من
+
+530
+00:35:55,510 --> 00:35:57,870
+هناك و من هناك و من هناك و من هناك و من هناك و من
+
+531
+00:35:57,870 --> 00:35:58,550
+هناك و من هناك و من هناك و من هناك و من هناك و من
+
+532
+00:35:58,550 --> 00:35:59,190
+هناك و من هناك و من هناك و من هناك و من هناك و من
+
+533
+00:35:59,190 --> 00:36:00,090
+هناك و من هناك و من هناك و من هناك و من هناك و من
+
+534
+00:36:00,090 --> 00:36:07,950
+هناك و من هناك و من هناك و من هناك و من هناك و من
+
+535
+00:36:07,950 --> 00:36:16,690
+هناك و من هناك و
+
+536
+00:36:16,690 --> 00:36:21,170
+من هناك وو يجب أن يأخذوا المال أولا، حتى لو لم يكن
+
+537
+00:36:21,170 --> 00:36:26,110
+هناك أي شيء موجود خلفه، كل ما لديك حنين، لديك £50
+
+538
+00:36:26,110 --> 00:36:31,870
+,000 و انت مالك و لديك خمس مؤمنين و أنا الوحيد
+
+539
+00:36:31,870 --> 00:36:37,690
+الان مؤمن بأمان و لدي مواصلة و مالي £60,000،
+
+540
+00:36:37,690 --> 00:36:41,400
+أستطيع أن أخذ الـ£50,000and nothing can be left
+
+541
+00:36:41,400 --> 00:36:44,740
+behind for the rest of the creditors because ..
+
+542
+00:36:44,740 --> 00:36:46,780
+because .. because of what? can you read it؟
+
+543
+00:36:46,780 --> 00:36:50,120
+داليا؟ generally the rights of secured creditors
+
+544
+00:36:50,120 --> 00:36:53,940
+to their collateral .. collateral دمانات
+
+545
+00:36:53,940 --> 00:36:58,960
+continuous even though their debt is discharged
+
+546
+00:36:58,960 --> 00:37:03,040
+example .. example absent some arrangement by a
+
+547
+00:37:03,040 --> 00:37:09,180
+debtor to surrender a car or reaffirm a debtالمالك
+
+548
+00:37:09,180 --> 00:37:14,820
+مع مهتمة أمان في سيارة المال يمكن أن يتعامل
+
+549
+00:37:14,820 --> 00:37:19,460
+بالسيارة حتى وإن المال للمالك هو هذه السيارة لدينا
+
+550
+00:37:19,460 --> 00:37:24,060
+مثال هنا في الواضح أن السيارة كانت المواصفة،
+
+551
+00:37:24,060 --> 00:37:27,880
+السيارة نفسها، ربما كانت المنزل، ربما قطعة الأرض،
+
+552
+00:37:27,880 --> 00:37:30,460
+مثلًا أعطيك 20 ألف رمز، ولكن لا أستطيع أن أخذ
+
+553
+00:37:30,460 --> 00:37:34,980
+مواصفة التي هي سيارتك، أبقيها معك، ولكن المواصفة
+
+554
+00:37:34,980 --> 00:37:40,780
+هي السيارة التجاريةإذا أصبحت مالك مغامر و قائدك
+
+555
+00:37:40,780 --> 00:37:44,240
+أخذ سيارتك أستطيع أن أتبعها أستطيع أن أخذها من أي
+
+556
+00:37:44,240 --> 00:37:57,520
+شخص مالك
+
+557
+00:37:57,520 --> 00:37:58,600
+مالك مالك مالك مالك مالك مالك مالك مالك مالك مالك
+
+558
+00:37:58,600 --> 00:37:58,700
+مالك مالك مالك مالك مالك مالك مالك مالك مالك مالك
+
+559
+00:37:58,700 --> 00:37:58,740
+مالك مالك مالك مالك مالك مالك مالك مالك مالك مالك
+
+560
+00:37:58,740 --> 00:37:58,840
+مالك مالك مالك مالك مالك مالك مالك
+
+561
+00:38:07,130 --> 00:38:12,110
+القرن 13 حتى في أضافة لـ Secured Creditors يمكن أن
+
+562
+00:38:12,110 --> 00:38:15,730
+ترى أنهم يمكن أن يكونوا ملازمين لدفعات أكتر من
+
+563
+00:38:15,730 --> 00:38:18,510
+الاستثمار الاستثمار الاستثمار الاستثمار الاستثمار
+
+564
+00:38:18,510 --> 00:38:22,210
+الاستثمار الاستثمار الاستثمار الاستثمار الاستثمار
+
+565
+00:38:22,210 --> 00:38:22,490
+الاستثمار الاستثمار الاستثمار الاستثمار الاستثمار
+
+566
+00:38:22,490 --> 00:38:22,530
+الاستثمار الاستثمار الاستثمار الاستثمار الاستثمار
+
+567
+00:38:22,530 --> 00:38:22,670
+الاستثمار الاستثمار الاستثمار الاستثمار الاستثمار
+
+568
+00:38:22,670 --> 00:38:24,590
+الاستثمار الاستثمار الاستثمار الاستثمار الاستثمار
+
+569
+00:38:24,590 --> 00:38:26,650
+الاستثمار الاستثمار الاستثمار الاستثمار الاستثمار
+
+570
+00:38:26,650 --> 00:38:31,210
+الاستre-organization ليس liquidation، إنها re
+
+571
+00:38:31,210 --> 00:38:35,950
+-organization تتكلم عن محافظة المملكة، موقف جميع
+
+572
+00:38:35,950 --> 00:38:38,870
+الأسات، نفس الشيء، أنا أقصد أنه لا يوجد شيء جديد
+
+573
+00:38:38,870 --> 00:38:43,630
+هنا، إنه يتكلم عن مخطط التعافي والذي ذكرته قبل،
+
+574
+00:38:43,630 --> 00:38:46,510
+يجب أن نكون لدينا مخطط، لا يمكنك التطبيق لتعافي
+
+575
+00:38:46,510 --> 00:38:51,810
+بدون مخطط، وهذا المخطط يجب أن يتم بين اثنين أشخاص،
+
+576
+00:38:51,810 --> 00:38:56,750
+الأول هو المالك، يمكنه أن يجلس مع شخص ما يسمى
+
+577
+00:38:56,750 --> 00:39:01,520
+مصاريفIt can be a lawyer, it can be an accountant,
+
+578
+00:39:02,460 --> 00:39:06,480
+we call him insolvency practitioner, we'll look at
+
+579
+00:39:06,480 --> 00:39:10,620
+them later on Insolvency practitioner, this is a
+
+580
+00:39:10,620 --> 00:39:14,260
+specialist person, can sit down with the debtor,
+
+581
+00:39:14,640 --> 00:39:16,860
+make a calculation, look at the account and the
+
+582
+00:39:16,860 --> 00:39:19,340
+money and what you have in the market and all the
+
+583
+00:39:19,340 --> 00:39:22,760
+assets you have and how much money you can make
+
+584
+00:39:22,760 --> 00:39:25,320
+and how long time it would take
+
+585
+00:39:27,890 --> 00:39:32,990
+وهذا كل شيء سيكون في ملف واحد مع وضعه ووضعه سيكون
+
+586
+00:39:32,990 --> 00:39:35,090
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+587
+00:39:35,090 --> 00:39:35,250
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+588
+00:39:35,250 --> 00:39:36,970
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+589
+00:39:36,970 --> 00:39:39,010
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+590
+00:39:39,010 --> 00:39:39,430
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+591
+00:39:39,430 --> 00:39:40,670
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+592
+00:39:40,670 --> 00:39:45,670
+الوثيقة الوثيقة الوثيقة الو
+
+593
+00:39:46,880 --> 00:39:49,340
+في هذه الحالة .. أعتقد أننا سننظر إلى هذا لاحقًا
+
+594
+00:39:49,340 --> 00:39:53,220
+في يوكيب .. يجب أن يكون لديك تقريبًا تلتين تقريبًا
+
+595
+00:39:53,220 --> 00:39:58,240
+ليس نصف تقريبًا على الأقل يجب أن تكون تقريبًا
+
+596
+00:39:58,240 --> 00:40:00,920
+تلتين تقريبًا لتقريب هذا البرنامج من المستخدمين ..
+
+597
+00:40:00,920 --> 00:40:05,440
+هذا هو الموضوع المهم .. أنا أعمل برنامج .. يجب أن
+
+598
+00:40:05,440 --> 00:40:08,640
+أثبت المستخدمين أني سأجيب عليهم .. إذا لم يقبلوا
+
+599
+00:40:08,640 --> 00:40:10,960
+.. إذا لم يقبلوا ..
+
+600
+00:40:12,770 --> 00:40:17,190
+ولكن إذا اقبلت 2 ثورة منهم بهذه القرارات، فهذه
+
+601
+00:40:17,190 --> 00:40:23,770
+القرارات ستتمتع بالحكومة لإختيارها، حتى لو لم تحصل
+
+602
+00:40:23,770 --> 00:40:28,750
+على المقابلين كلهم، فهذا بخير، يجب أن يكون المجتمع
+
+603
+00:40:28,750 --> 00:40:35,950
+يقبل هذه القرارات، ولكن المجتمع، 1 ثورة منهم، لا
+
+604
+00:40:35,950 --> 00:40:41,050
+نهتم بهم بعدنحن نلقي نظرة على أكتر من المستخدمين
+
+605
+00:40:41,050 --> 00:40:45,250
+الذين يمتلكون أكتر من المال، نلقي نظرة على هذا و
+
+606
+00:40:45,250 --> 00:40:48,190
+ذلك في التفاصيل لاحقا، المستخدمين الذين يمتلكون
+
+607
+00:40:48,190 --> 00:40:52,730
+أكتر من المال، نرى أنني كنت مستخدم لـ 600 ألف
+
+608
+00:40:52,730 --> 00:40:55,050
+pound، 600 ألف pound،
+
+609
+00:40:57,610 --> 00:41:02,770
+أولئك الذين لديهم أقل من 400 ألف دولار لتخلص من
+
+610
+00:41:02,770 --> 00:41:07,190
+المال والباقين من المستخدمين لم يكنوا مهتمين بهم
+
+611
+00:41:07,190 --> 00:41:14,470
+بشكل كبير، يجب أن يقبلوا تقرار مثل هذا يمكننا
+
+612
+00:41:14,470 --> 00:41:19,820
+أن نجرح ما لدينا بقول أن لدينا إخلاصعن طريق
+
+613
+00:41:19,820 --> 00:41:24,800
+التعامل مرة أخرى فقط رأينا أننا لدينا مجموعة غير
+
+614
+00:41:24,800 --> 00:41:28,240
+مجرم للشركات كما قلت قبلها ليس هناك شيء جديد هنا
+
+615
+00:41:28,240 --> 00:41:31,820
+ولكن في المرة التالية يجب أن ننظر إلى الفترة في
+
+616
+00:41:31,820 --> 00:41:33,980
+الولايات المتحدة في التي لدينا الكثير من المعلومات
+
+617
+00:41:33,980 --> 00:41:38,420
+يجب أن ننظر إلى التفاصيل التفاصيل نحن لدينا
+
+618
+00:41:38,420 --> 00:41:44,800
+التعامل ونحن لدينا التعامل التعامل يعني التعامل
+
+619
+00:41:44,800 --> 00:41:49,360
+مرة أخرى نفس الشيء في اللي هناوهيبقى the debtor to
+
+620
+00:41:49,360 --> 00:41:54,340
+allow him to use a future earningعشان انا ممكن
+
+621
+00:41:54,340 --> 00:41:56,660
+احصل من المال اللي احصل من المال اللي احصل من
+
+622
+00:41:56,660 --> 00:41:57,240
+المال اللي احصل من المال اللي احصل من المال اللي
+
+623
+00:41:57,240 --> 00:41:59,020
+احصل من المال اللي احصل من المال اللي احصل من
+
+624
+00:41:59,020 --> 00:41:59,700
+المال اللي احصل من المال اللي احصل من المال اللي
+
+625
+00:41:59,700 --> 00:41:59,840
+احصل من المال اللي احصل من المال اللي احصل من
+
+626
+00:41:59,840 --> 00:41:59,960
+المال اللي احصل من المال اللي احصل من المال اللي
+
+627
+00:41:59,960 --> 00:42:01,900
+احصل من المال اللي احصل من المال اللي احصل من
+
+628
+00:42:01,900 --> 00:42:02,500
+المال اللي احصل من المال اللي احصل من المال اللي
+
+629
+00:42:02,500 --> 00:42:03,340
+احصل من المال اللي احصل من المال اللي احصل من
+
+630
+00:42:03,340 --> 00:42:05,900
+المال اللي احصل من المال اللي احصل من المال اللي
+
+631
+00:42:05,900 --> 00:42:16,000
+احصل من المال اللي احصل من المال اللي
+
+632
+00:42:16,000 --> 00:42:16,220
+ا
+
+633
+00:42:23,130 --> 00:42:26,590
+يمكن أن تكون هناك سؤال مثل هذا يقول أن بعد أن نقوم
+
+634
+00:42:26,590 --> 00:42:30,230
+بإطلاق الانتجار الانتجار يوجد بعض المسؤلات على
+
+635
+00:42:30,230 --> 00:42:35,590
+البيانات ومسؤلات أخرى على الانتجار واحدة منها ..
+
+636
+00:42:35,590 --> 00:42:39,570
+هل أستطيع أن أقول؟ الانتجار لا يستطيع أن يجمع
+
+637
+00:42:39,570 --> 00:42:44,130
+المال من الخارج من المقالات الوحيد الوحيد الوحيد
+
+638
+00:42:44,130 --> 00:42:47,990
+من طريقة الانتجار أن يجمع المالالسلسلات او
+
+639
+00:42:47,990 --> 00:42:51,970
+الانفجار نحن لدينا فقط كما قلت واحد طريق وهو
+
+640
+00:42:51,970 --> 00:42:55,350
+الوحيد الطريق الانفجار لا يمكنه يطلب المال لا
+
+641
+00:42:55,350 --> 00:42:58,950
+يمكنك أن تذهب غير مفهوم لا يمكنك أن تذهب و تنظر في
+
+642
+00:42:58,950 --> 00:43:01,850
+الباب لا يمكنك أن تذهب لعبارة أخر لا يمكنك أن تذهب
+
+643
+00:43:01,850 --> 00:43:08,490
+للعبارة الوحيد الطريق هو السلسلات الانفجارالحكومة
+
+644
+00:43:08,490 --> 00:43:13,810
+لا تسمح للمستخدم الوظيفة التي تم إعلانها كجزء من
+
+645
+00:43:13,810 --> 00:43:17,130
+مجلس الحكومة لتقديم الوظيفة على نفس الوقت الوظيفة
+
+646
+00:43:17,130 --> 00:43:20,050
+لن تكون قادرة على تقديم الوظيفة على نفس الوقت
+
+647
+00:43:20,050 --> 00:43:23,230
+مثلًا، لنقول اليوم، لقد أعلننا اليوم أننا سنقوم
+
+648
+00:43:23,230 --> 00:43:28,110
+بالتغيير و سيكون لدينا مؤسسة مستخدم مستخدم مستخدم
+
+649
+00:43:28,110 --> 00:43:28,610
+مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم
+
+650
+00:43:28,610 --> 00:43:29,150
+مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم
+
+651
+00:43:29,150 --> 00:43:31,330
+مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم
+
+652
+00:43:31,330 --> 00:43:34,650
+مستخدم
+
+653
+00:43:37,690 --> 00:43:40,710
+فالدتر في هذه اللحظة لا يستطيع أن يبيع أي شيء حتى
+
+654
+00:43:40,710 --> 00:43:44,710
+لو كان في اسمه كل شيء كان في اسمه حتى تلك اللحظة
+
+655
+00:43:44,710 --> 00:43:50,990
+لا يستطيع أن يبيع أي شيء حتى لو كان في اسمه كل شيء
+
+656
+00:43:50,990 --> 00:43:54,810
+كان في اسمه كل شيء كان في اسمه كل شيء كان في اسمه
+
+657
+00:43:54,810 --> 00:43:56,590
+كل شيء كان في اسمه كل شيء كان في اسمه كل شيء كان
+
+658
+00:43:56,590 --> 00:44:04,330
+في اسمه كل
+
+659
+00:44:04,330 --> 00:44:07,960
+شيء كان فيهو غير صحيح إذا كان المسلسل يريد أن يسحق
+
+660
+00:44:07,960 --> 00:44:10,400
+أي شيء بسبب حياته أو حياته أو حياته أو حياته أو
+
+661
+00:44:10,400 --> 00:44:11,040
+حياته أو حياته أو حياته أو حياته أو حياته أو حياته
+
+662
+00:44:11,040 --> 00:44:11,440
+أو حياته أو حياته أو حياته أو حياته أو حياته أو
+
+663
+00:44:11,440 --> 00:44:14,120
+حياته أو حياته أو حياته أو حياته أو حياته أو حياته
+
+664
+00:44:14,120 --> 00:44:14,500
+أو حياته أو حياته أو حياته أو حياته أو حياته أو
+
+665
+00:44:14,500 --> 00:44:15,640
+حياته أو حياته أو حياته أو حياته أو حياته أو حياته
+
+666
+00:44:15,640 --> 00:44:20,920
+أو حياته أو حياته أو حياته أو حياته أو حياته أو
+
+667
+00:44:20,920 --> 00:44:25,620
+حياته أو حياته
+
+668
+00:44:36,240 --> 00:44:42,280
+هي مجموعة مختلفة ومجموعة مختلفة ومجموعة مختلفة
+
+669
+00:44:42,280 --> 00:44:43,220
+ومجموعة مختلفة ومجموعة مختلفة ومجموعة مختلفة
+
+670
+00:44:43,220 --> 00:44:45,200
+ومجموعة مختلفة ومجموعة مختلفة ومجموعة مختلفة
+
+671
+00:44:45,200 --> 00:44:49,140
+ومجموعة مختلفة ومجموعة
+
+672
+00:44:49,140 --> 00:44:51,640
+مختلفة ومجموعة مختلفة ومجموعة مختلفة ومجموعة
+
+673
+00:44:51,640 --> 00:45:04,700
+مختلفة ومجموعة مختلفة ومجموعة مختلفة ومج
+
+674
+00:45:07,140 --> 00:45:12,400
+وهذه الاقتصاد يمكن أن يتم تحميله باستخدام
+
+675
+00:45:12,400 --> 00:45:16,560
+القواعد التي تم إستخدامها في الولايات المتحدة في
+
+676
+00:45:16,560 --> 00:45:18,260
+الواقع في الواقع في الولايات المتحدة في الولايات
+
+677
+00:45:18,260 --> 00:45:19,620
+المتحدة في الولايات المتحدة في الولايات المتحدة في
+
+678
+00:45:19,620 --> 00:45:20,680
+الولايات المتحدة في الولايات المتحدة في الولايات
+
+679
+00:45:20,680 --> 00:45:23,600
+المتحدة في الولايات المتحدة في الولايات المتحدة في
+
+680
+00:45:23,600 --> 00:45:24,600
+الولايات المتحدة في الولايات المتحدة في الولايات
+
+681
+00:45:24,600 --> 00:45:25,880
+المتحدة في الولايات المتحدة في الولايات المتحدة في
+
+682
+00:45:25,880 --> 00:45:26,940
+الولايات المتحدة في الولايات المتحدة في الولايات
+
+683
+00:45:26,940 --> 00:45:30,520
+المتحدة في الولايات المتحدة في الولايات المتحدة في
+
+684
+00:45:30,630 --> 00:45:32,470
+They look like the same, there's not much
+
+685
+00:45:32,470 --> 00:45:34,550
+difference between them. Dealing with debts,
+
+686
+00:45:35,290 --> 00:45:37,250
+debtors cannot be .. as I said we have debt,
+
+687
+00:45:37,710 --> 00:45:41,430
+debtors, payments. Somebody cannot pay his debts
+
+688
+00:45:41,430 --> 00:45:45,530
+and it's optional. We said before that we have
+
+689
+00:45:45,530 --> 00:45:48,270
+voluntary and involuntary
+
+690
+00:45:50,120 --> 00:45:52,820
+هو افضل، انت ممكن تفعيله، اذا كنت تريد أن تدفع
+
+691
+00:45:52,820 --> 00:45:55,120
+المال، يمكنك أن تدفعه، اذا كنت تريد ان تعمل عمل
+
+692
+00:45:55,120 --> 00:45:57,460
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+693
+00:45:57,460 --> 00:45:58,340
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+694
+00:45:58,340 --> 00:45:59,000
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+695
+00:45:59,000 --> 00:45:59,360
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+696
+00:45:59,360 --> 00:45:59,460
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+697
+00:45:59,460 --> 00:46:08,320
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+698
+00:46:08,320 --> 00:46:17,600
+ع
+
+699
+00:46:19,160 --> 00:46:23,680
+ولكن حتى هذا الانتقال الجديد مجرد بعض الانقلاجات
+
+700
+00:46:23,680 --> 00:46:29,280
+وعندما تكون لديك الانتقال وحرية وعندما تريد أن
+
+701
+00:46:29,280 --> 00:46:32,960
+تعود للعمل في المستقبل يمكنك أن تعود للعمل بالطبع
+
+702
+00:46:32,960 --> 00:46:37,520
+يمكنك أن تطلب المسمح للمجلد ويمكنك أن تعود للعمل
+
+703
+00:46:37,520 --> 00:46:41,960
+ولكن في هذه اللحظة لن تكون لديك حرية تمامة لديك
+
+704
+00:46:41,960 --> 00:46:45,740
+بعض الانقلاجات لأنك كنت مخطط في الماضي فإذا كنت
+
+705
+00:46:45,740 --> 00:46:49,930
+تريد أن تكون لديك انتقال جديدrestriction في قيود
+
+706
+00:46:49,930 --> 00:46:54,610
+and as we said before that we have the assets
+
+707
+00:46:54,610 --> 00:46:59,010
+shared fairly between creditors and there's
+
+708
+00:46:59,010 --> 00:47:02,050
+something I want you to focus on here look first
+
+709
+00:47:02,050 --> 00:47:07,290
+-time bankrupts يا حنين first-time bankrupt was
+
+710
+00:47:07,290 --> 00:47:11,090
+given when the general receive their their just
+
+711
+00:47:11,090 --> 00:47:15,870
+discharge one year after the death of the bankrupt
+
+712
+00:47:15,870 --> 00:47:16,350
+CEO
+
+713
+00:47:22,190 --> 00:47:27,990
+هو حسنًا، دعنا نقول هذا، يجب أن نطلق حرص الانفجار،
+
+714
+00:47:27,990 --> 00:47:33,630
+كانت القرار مجرد قرار مجرد
+
+715
+00:47:33,630 --> 00:47:35,490
+حرص الانفجار، كانت القرار مجرد حرص الانفجار، كانت
+
+716
+00:47:35,490 --> 00:47:35,510
+القرار مجرد حرص الانفجار، كانت القرار مجرد حرص
+
+717
+00:47:35,510 --> 00:47:37,490
+الانفجار، كانت القرار مجرد حرص الانفجار، كانت
+
+718
+00:47:37,490 --> 00:47:41,750
+القرار مجرد حرص الانفجار، كانت القرار مجرد حرص
+
+719
+00:47:41,750 --> 00:47:49,210
+الانفجار،
+
+720
+00:47:49,210 --> 00:47:53,260
+كانت القراريستطيع أن يأخذ وقت طويل يستطيع أن يأخذ
+
+721
+00:47:53,260 --> 00:47:54,500
+وقت طويل يستطيع أن يأخذ وقت طويل يستطيع أن يأخذ
+
+722
+00:47:54,500 --> 00:47:57,760
+وقت طويل يستطيع أن يأخذ وقت طويل يستطيع أن يأخذ
+
+723
+00:47:57,760 --> 00:47:59,000
+وقت طويل يستطيع أن يأخذ وقت طويل يستطيع أن يأخذ
+
+724
+00:47:59,000 --> 00:47:59,720
+وقت طويل يستطيع أن يأخذ وقت طويل يستطيع أن يأخذ
+
+725
+00:47:59,720 --> 00:48:02,440
+وقت طويل يستطيع أن يأخذ وقت طويل يستطيع أن يأخذ
+
+726
+00:48:02,440 --> 00:48:03,700
+وقت طويل يستطيع أن يأخذ وقت طويل يستطيع أن يأخذ
+
+727
+00:48:03,700 --> 00:48:07,000
+وقت طويل يستطيع أن يأخذ وقت طويل يستطيع أن يأخذ
+
+728
+00:48:07,000 --> 00:48:12,400
+وقت
+
+729
+00:48:12,400 --> 00:48:16,130
+طويلاليوم لديك حكومة و إعفار فيه قرار خلاص حكومة
+
+730
+00:48:16,130 --> 00:48:19,710
+لفلاس it takes one year to have a district court
+
+731
+00:48:19,710 --> 00:48:23,050
+اعفار I mean within this time from this time to
+
+732
+00:48:23,050 --> 00:48:27,750
+this time let's say from 2000 2001
+
+733
+00:48:27,750 --> 00:48:32,090
+one year within this 12 month any money any extra
+
+734
+00:48:32,090 --> 00:48:35,710
+money you have you have to give it to the trustee
+
+735
+00:48:35,710 --> 00:48:39,130
+this it means any extra money I have within this
+
+736
+00:48:39,130 --> 00:48:45,770
+12 monthالأكثر المال يجب أن أعطيه للحكومة بعد 12
+
+737
+00:48:45,770 --> 00:48:49,370
+أشهر بعد أن نحصل على هذه الحاجة أي أكتر المال يجب
+
+738
+00:48:49,370 --> 00:48:52,950
+أن أعطيه هو مني لا أحد يستطيع أن يسألني بعض
+
+739
+00:48:52,950 --> 00:48:58,770
+الأحيان يستغرق أكتر من سنة يستغرق 2,3,4,5 يستغرق
+
+740
+00:48:58,770 --> 00:49:05,750
+إذا كانت أخر مرة يستغرق عدد المال يستغرق
+
+741
+00:49:05,750 --> 00:49:09,060
+عدد الحكومةبالنسبة للمدرسة أيضًا ثم يمكن أن يكون
+
+742
+00:49:09,060 --> 00:49:12,740
+هناك شيء يسمى في نهاية اليوم انسلفانية تتعامل مع
+
+743
+00:49:12,740 --> 00:49:16,920
+انسلفانية انسلفانية في هذه الحالة انسلفانية يعني
+
+744
+00:49:16,920 --> 00:49:22,260
+انسلفانية و انا قلت اذا كنا نقول انسلفانية أكتر من
+
+745
+00:49:22,260 --> 00:49:27,040
+الوقت يعني انسلفانية انسلفانية و حتى في مجتمع هنا
+
+746
+00:49:27,040 --> 00:49:32,180
+الناس يقولون انسلفانية يعني انسلفانية يعني
+
+747
+00:49:32,180 --> 00:49:37,540
+انسلفانية ليس تحويلبالنسبة لـ Insolvency لديه
+
+748
+00:49:37,540 --> 00:49:45,680
+Stigma سوف ننظر في المرة القادمة على الانهيار كيف
+
+749
+00:49:45,680 --> 00:49:53,080
+يمكنه أن يشعر بالانهيار In the UK أيضًا لديهم
+
+750
+00:49:53,080 --> 00:49:57,180
+تغيير للانهيار الانهيار الانهيار الانهيار الانهيار
+
+751
+00:49:57,180 --> 00:50:04,680
+الانهيار الانهيار الانهيار الانهيار الانهيار
+
+752
+00:50:05,790 --> 00:50:09,990
+هذه افتراضية وهي متساوية لـ Reorganization في
+
+753
+00:50:09,990 --> 00:50:13,150
+الولايات المتحدة نسميها Reorganization في الولايات
+
+754
+00:50:13,150 --> 00:50:16,350
+المتحدة نسميها IVA Individual Voluntary
+
+755
+00:50:16,350 --> 00:50:22,670
+Arrangement هو يعني تسوير هو عادة جدولة نفس الشيء
+
+756
+00:50:22,670 --> 00:50:26,390
+ننظر
+
+757
+00:50:26,390 --> 00:50:30,470
+إلى الاختصاراتالسلسلات اللي لديها ليست نفسها،
+
+758
+00:50:30,470 --> 00:50:34,930
+تتعامل مع حالتها، تتعامل مع المال اللي لدينا،
+
+759
+00:50:34,930 --> 00:50:39,930
+تتعامل مع موقعنا، تتعامل مع ما لدينا هنا، كما ترى،
+
+760
+00:50:39,930 --> 00:50:43,910
+لدينا السلسلات الانفجارية ليست نفسها، لكنها يمكن
+
+761
+00:50:43,910 --> 00:50:46,990
+أن تكون في بعض الأحيان مستخدمة أو غير مستخدمة أو
+
+762
+00:50:46,990 --> 00:50:50,970
+IVA كما لدينا قبل ذلك، مستخدمة أو غير مستخدمة يعني
+
+763
+00:50:52,500 --> 00:50:55,460
+بالإضافة لـ Bankruptcy Petition التي تم إضافتها
+
+764
+00:50:55,460 --> 00:50:59,420
+الـ Data بمجرد ذلك بمجرد ذلك بمجرد ذلك بمجرد ذلك
+
+765
+00:50:59,420 --> 00:51:03,520
+بمجرد ذالك بمجرد ذالك بمجرد ذالك بمجرد ذالك بمجرد
+
+766
+00:51:03,520 --> 00:51:05,100
+ذالك بمجرد ذالك بمجرد ذالك بمجرد ذالك بمجرد ذالك
+
+767
+00:51:05,100 --> 00:51:05,120
+بمجرد ذالك بمجرد ذالك بمجرد ذالك بمجرد ذالك بمجرد
+
+768
+00:51:05,120 --> 00:51:07,040
+ذالك بمجرد ذالك بمجرد ذالك بمجرد ذالك ب
+
+769
+00:51:24,730 --> 00:51:27,830
+طبعا تقول انك تستطيع الاستخدام اذا كنت قد قدر
+
+770
+00:51:27,830 --> 00:51:31,190
+المدينة
+
+771
+00:51:31,190 --> 00:51:31,630
+ان تستخدم المدينة اذا كنت قدر المدينة ان تستخدم
+
+772
+00:51:31,630 --> 00:51:33,810
+المدينة اذا كنت قدر المدينة ان تستخدم المدينة اذا
+
+773
+00:51:33,810 --> 00:51:34,130
+كنت قدر المدينة ان تستخدم المدينة اذا كنت قدر
+
+774
+00:51:34,130 --> 00:51:34,810
+المدينة ان تستخدم المدينة اذا كنت قدر المدينة ان
+
+775
+00:51:34,810 --> 00:51:35,430
+تستخدم المدينة اذا كنت قدر المدينة ان تستخدم
+
+776
+00:51:35,430 --> 00:51:37,450
+المدينة اذا كنت قدر المدينة ان تستخدم المدينة اذا
+
+777
+00:51:37,450 --> 00:51:39,410
+كنت قدر المدينة ان تستخدم المدينة اذا كنت قدر
+
+778
+00:51:39,410 --> 00:51:49,670
+المدينة ان تستخدم المدينة اذا
+
+779
+00:51:49,670 --> 00:51:57,330
+كنت قلا نستطيع أن نقول لا كدتر انا لن اقف هنا انا
+
+780
+00:51:57,330 --> 00:52:01,710
+سأجعله يتعامل بالكامل الدتر يجب أن يتعامل بالكامل
+
+781
+00:52:01,710 --> 00:52:06,530
+مع الاختصارات اذا لم يتعامل الدتر يعني انه ليس
+
+782
+00:52:06,530 --> 00:52:13,450
+صادق انه ليس صادق وإذا لم يكن صادق او صادق فإن
+
+783
+00:52:13,450 --> 00:52:15,390
+الاختصار صح
+
+784
+00:52:18,280 --> 00:52:22,480
+هو ضده، فهو لن يكون حتى مرحبًا، فهو لن يكون لديه
+
+785
+00:52:22,480 --> 00:52:27,360
+هذه التاريخة، لذلك عندما يبدأ التقاليد، فيجب أن
+
+786
+00:52:27,360 --> 00:52:32,100
+يكون المدير يتعامل تمامًا. إذا أسأل الشرطة أن يقوم
+
+787
+00:52:32,100 --> 00:52:34,920
+بإجابته، يجب أن تقوم بذلك. إذا كان عليك أن تحضر
+
+788
+00:52:34,920 --> 00:52:37,680
+مصطلحة، مصطلحة البنك، يجب أن تحضر مصطلحة البنك.
+
+789
+00:52:39,600 --> 00:52:44,280
+إذا كان عليك أن تشرح أي مقال، يجب أن تشرحه. لا
+
+790
+00:52:44,280 --> 00:52:46,560
+يمكنك أن تقول، لا يمكنك أن تقول لا.
+
+791
+00:52:53,710 --> 00:52:59,390
+البرنامج تبدأ بإصلاح الانقلاب الانقلاب الانقلاب
+
+792
+00:52:59,390 --> 00:53:02,690
+الانقلاب الانقلاب الانقلاب الانقلاب الانقلاب
+
+793
+00:53:02,690 --> 00:53:03,590
+الانقلاب الانقلاب الانقلاب الانقلاب الانقلاب
+
+794
+00:53:03,590 --> 00:53:04,230
+الانقلاب الانقلاب الانقلاب الانقلاب الانقلاب
+
+795
+00:53:04,230 --> 00:53:05,470
+الانقلاب الانقلاب الانقلاب الانقلاب الانقلاب
+
+796
+00:53:05,470 --> 00:53:05,990
+الانقلاب الانقلاب الانقلاب الانقلاب الانقلاب
+
+797
+00:53:05,990 --> 00:53:10,980
+الانقلاب الانقلاب الانقلاب الانقلاب الالثاني هو
+
+798
+00:53:10,980 --> 00:53:16,200
+يجمع المال و الأسات التي يمكنه شرحها و يمكنه جمع
+
+799
+00:53:16,200 --> 00:53:22,580
+كل شيء مفيد عن الجزء الاجتماعي من المال في حياته و
+
+800
+00:53:22,580 --> 00:53:25,960
+من هنا نستطيع أن نبدأ حتى نحصل على القرار الأخير
+
+801
+00:53:25,960 --> 00:53:30,000
+لتحرير الأمر حتى نحصل على تحرير المساعدة هذه هي
+
+802
+00:53:30,000 --> 00:53:36,990
+الاختصاراتنستطيع أن نفعلها بإيقاف تسوية نستطيع أن
+
+803
+00:53:36,990 --> 00:53:40,830
+نصل إلى تسوية تسوية تسوية تستطيع أن تكون بين دتر
+
+804
+00:53:40,830 --> 00:53:45,190
+وكريلتر وعندما نصل إلى تسوية تسوية تسوية تستطيع أن
+
+805
+00:53:45,190 --> 00:53:47,490
+نصل إلى تسوية تسوية تسوية تسوية تستطيع أن نصل إلى
+
+806
+00:53:47,490 --> 00:53:49,090
+تسوية تسوية تسوية تسوية تسوية تسوية تسوية تسوية
+
+807
+00:53:49,090 --> 00:53:49,970
+تسوية تسوية تسوية تسوية تسوية تسوية تسوية تسوية
+
+808
+00:53:49,970 --> 00:53:53,610
+تسوية تسوية تسوية تسوية تسوية
+
+809
+00:53:53,610 --> 00:54:00,370
+تس
+
+810
+00:54:01,310 --> 00:54:05,350
+هذه الأفعال .. بالطبع عندما تطلع لتطبيق مغامرة إذا
+
+811
+00:54:05,350 --> 00:54:08,810
+كنت ترغب في تطبيق أي شيء .. إذا قمت بإطلاق أي طلب
+
+812
+00:54:08,810 --> 00:54:13,290
+للحكومة .. حتى إذا لم يكن مغامرة .. على حق .. يجب
+
+813
+00:54:13,290 --> 00:54:16,710
+أن تقوم بإطلاق الأفعال .. في بلسترنك الأفعال يجب
+
+814
+00:54:16,710 --> 00:54:21,550
+أن تكون 1% من المال .. كم هي؟ في الولايات المتحدة،
+
+815
+00:54:21,550 --> 00:54:29,290
+يقول الحكومة أن أفعال الحكومة 120 ريالوهي لا شيء
+
+816
+00:54:29,290 --> 00:54:32,970
+فقط قليل من المال و أحيانا و حتى أحيانا يمكن أن
+
+817
+00:54:32,970 --> 00:54:39,850
+يكون هذا الـ £120 هنا مخرج
+
+818
+00:54:39,850 --> 00:54:42,930
+من هنا، لماذا؟ لأن إذا لم يكن لديك إيقاف و إذا كان
+
+819
+00:54:42,930 --> 00:54:49,380
+هذا الـكان على مدارس الدولة والدولة كانت مستغربة
+
+820
+00:54:49,380 --> 00:54:53,220
+من الدولة هو لا يحصل على المال الناس في اليوكي
+
+821
+00:54:53,220 --> 00:54:57,160
+اللي لا يملكوا المال اللي لا يعملوا لا يعملوا
+
+822
+00:54:57,160 --> 00:54:59,820
+يمكنهم أن يحصلوا على شيء يسمى مدارس الدولة والدولة
+
+823
+00:54:59,820 --> 00:55:02,740
+والدولة هي مدارس الدولة والدولة هي مدارس الدولة
+
+824
+00:55:02,740 --> 00:55:05,400
+والدولة هي مدارس الدولة هي مدارس الدولة هي مدارس
+
+825
+00:55:05,400 --> 00:55:05,900
+الدولة هي مدارس الدولة هي مدارس الدولة هي مدارس
+
+826
+00:55:05,900 --> 00:55:06,460
+الدولة هي مدارس الدولة هي مدارس الدولة هي مدارس
+
+827
+00:55:06,460 --> 00:55:06,560
+الدولة هي مدارس الدولة هي مدارس الدولة هي مدارس
+
+828
+00:55:06,560 --> 00:55:10,770
+الدولة هي مدارس الدولة هي مدارس الدreleased from
+
+829
+00:55:10,770 --> 00:55:13,050
+the amount of money which has to be paid as court
+
+830
+00:55:13,050 --> 00:55:16,230
+fees and there's something called deposit which is
+
+831
+00:55:16,230 --> 00:55:19,950
+250 this is not so important for you anyway once
+
+832
+00:55:19,950 --> 00:55:21,930
+you are in the UK you should know how much you
+
+833
+00:55:21,930 --> 00:55:24,270
+should pay for the court fees I mean at least you
+
+834
+00:55:24,270 --> 00:55:26,370
+have to know and even here sometimes you have to
+
+835
+00:55:26,370 --> 00:55:30,570
+be a statement of fear for the swear swear of a
+
+836
+00:55:30,570 --> 00:55:33,070
+statement of affairs حلفي اليمين there's some
+
+837
+00:55:33,070 --> 00:55:38,490
+money have to be paid with theمع المطالب اذا اتت
+
+838
+00:55:38,490 --> 00:55:41,590
+اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت
+
+839
+00:55:41,590 --> 00:55:43,490
+اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت
+
+840
+00:55:43,490 --> 00:55:46,970
+اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت
+
+841
+00:55:46,970 --> 00:55:47,370
+اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت
+
+842
+00:55:47,370 --> 00:55:48,690
+اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت
+
+843
+00:55:48,690 --> 00:55:48,790
+اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت
+
+844
+00:56:06,270 --> 00:56:08,930
+والثاني هو join petitions وعندما يكون لديهم job
+
+845
+00:56:08,930 --> 00:56:12,330
+petition فهي فقط فائقة واحدة وإلا كل واحد منهم
+
+846
+00:56:12,330 --> 00:56:17,200
+يحتاج إلى فائقة مختلفة شكرا لوقتكAlternative
+
+847
+00:56:17,200 --> 00:56:21,580
+dispute resolution arbitration. Arbitration is a
+
+848
+00:56:21,580 --> 00:56:26,320
+form of alternative dispute resolution and it's a
+
+849
+00:56:26,320 --> 00:56:31,520
+legal technique that used to resolve the dispute
+
+850
+00:56:31,520 --> 00:56:40,110
+outside the courtsهو يقوم بتحديث لإحدى أو أكثر
+
+851
+00:56:40,110 --> 00:56:46,710
+شخصين من الانتخابين. إنها تقليد تقنيات في الواقع
+
+852
+00:56:46,710 --> 00:56:48,330
+في الواقع تقليد تقليد تقنيات في الواقع تقليد تقليد
+
+853
+00:56:48,330 --> 00:56:51,430
+تقليد تقليد تقليد تقليد تقليد تقليد تقليد تقليد
+
+854
+00:56:51,430 --> 00:56:52,650
+تقليد تقليد تقليد تقليد تقليد تقليد تقليد تقليد
+
+855
+00:56:52,650 --> 00:56:53,050
+تقليد تقليد تقليد تقليد تقليد تقليد تقليد تقليد
+
+856
+00:56:53,050 --> 00:56:53,690
+تقليد تقليد تقليد تقليد تقليد تقليد تقليد تقليد
+
+857
+00:56:53,690 --> 00:56:58,430
+تقليد تقليد تقليد تقليد تقليد تقForms of
+
+858
+00:56:58,430 --> 00:57:02,370
+arbitration, mediations that a form of settlement
+
+859
+00:57:02,370 --> 00:57:06,350
+negotiation facilitated by a natural third party,
+
+860
+00:57:06,730 --> 00:57:10,650
+non-binding resolution
+
+861
+00:57:10,650 --> 00:57:14,950
+that applied
+
+862
+00:57:14,950 --> 00:57:19,870
+by who have a previous experience, voluntary or
+
+863
+00:57:19,870 --> 00:57:20,330
+mandatory
+
+864
+00:57:23,340 --> 00:57:26,460
+advantages and disadvantages advantages of
+
+865
+00:57:26,460 --> 00:57:30,440
+arbitration is often faster than litigation in
+
+866
+00:57:30,440 --> 00:57:33,820
+court and it can be cheaper and more flexible for
+
+867
+00:57:33,820 --> 00:57:37,160
+business and it's generally easier for enforced
+
+868
+00:57:37,160 --> 00:57:40,620
+than court judgments disadvantages
+
+869
+00:57:43,190 --> 00:57:47,270
+إذا كانت التجارب مجلسية ومدعومة، فإن الشركات لديها
+
+870
+00:57:47,270 --> 00:57:52,490
+حقوق لتساعد الحكومة وتجاربها لتقرر القضية. في بعض
+
+871
+00:57:52,490 --> 00:57:56,530
+التجارب التجاربية، يحتاج الشركات للدفع لتجارب
+
+872
+00:57:56,530 --> 00:57:57,670
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+873
+00:57:57,670 --> 00:57:58,410
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+874
+00:57:58,410 --> 00:58:01,170
+تجارب تجارب تجارب
+
+875
+00:58:04,570 --> 00:58:10,730
+التعاملات التجارية التجارية هي عملية تجارة تجارة
+
+876
+00:58:10,730 --> 00:58:13,290
+تجارة تجارة تجارة تجارة تجارة تجارة تجارة تجارة
+
+877
+00:58:13,290 --> 00:58:15,330
+تجارة تجارة تجارة تجارة تجارة تجارة تجارة تجارة
+
+878
+00:58:15,330 --> 00:58:15,690
+تجارة تجارة تجارة تجارة تجارة تجارة تجارة تجارة
+
+879
+00:58:15,690 --> 00:58:15,870
+تجارة تجارة تجارة تجارة تجارة تجارة تجارة تجارة
+
+880
+00:58:15,870 --> 00:58:18,190
+تجارة تجارة تجارة تجارة تجارة تجارة تجارة تجارة
+
+881
+00:58:18,190 --> 00:58:24,990
+تجارة تجارة تجارة تجارة تجارة تجارة تجارة تجارة
+
+882
+00:58:24,990 --> 00:58:29,570
+تجارة تج
+
+883
+00:58:30,620 --> 00:58:33,500
+type of agreements agreements which provide that
+
+884
+00:58:33,500 --> 00:58:36,560
+if a dispute should arise it will be resolved by
+
+885
+00:58:36,560 --> 00:58:40,360
+arbitration this will generally be normal contract
+
+886
+00:58:40,360 --> 00:58:42,960
+agreements which are signed after dispute has
+
+887
+00:58:42,960 --> 00:58:46,560
+reason agreeing that the dispute should be
+
+888
+00:58:46,560 --> 00:58:52,800
+resolved by arbitration and
+
+889
+00:58:52,800 --> 00:58:55,540
+now I will continue about and talk about the
+
+890
+00:58:55,540 --> 00:59:00,300
+applicable lawعندما نتكلم عن القوة المفترضة، القوة
+
+891
+00:59:00,300 --> 00:59:04,940
+تتحكم في اتفاق الانتخابات والقوة تتحكم في
+
+892
+00:59:04,940 --> 00:59:09,500
+الانتخابات ومقالاتها والقوة تتحكم في الانتخابات
+
+893
+00:59:09,500 --> 00:59:11,040
+ومقالاتها والقوة تتحكم في الانتخابات ومقالاتها
+
+894
+00:59:11,040 --> 00:59:14,840
+والقوة تتحكم في الانتخابات والقوة تتحكم في
+
+895
+00:59:14,840 --> 00:59:15,700
+الانتخابات والقوة تتحكم في الانتخابات والقوة تتحكم
+
+896
+00:59:15,700 --> 00:59:17,940
+في الانتخابات والقوة تتحكم في الانتخابات والقوة
+
+897
+00:59:17,940 --> 00:59:21,680
+تتحكم في الانتخابات والقوة تتحكم في الانتخابات
+
+898
+00:59:21,680 --> 00:59:24,810
+والقوة تتحكم في الانتخابات والقوة توالفعل بإن
+
+899
+00:59:24,810 --> 00:59:32,210
+اتفاق الانتخابات اتفاق الرئيسي اتفاق
+
+900
+00:59:32,210 --> 00:59:38,010
+الانتخابات اتفاق الرئيسي اتفاق الرئيسي اتفاق
+
+901
+00:59:38,010 --> 00:59:38,030
+الرئيسي اتفاق الرئيسي اتفاق الرئيسي اتفاق الرئيسي
+
+902
+00:59:38,030 --> 00:59:39,750
+اتفاق الرئيسي اتفاق الرئيسي اتفاق الرئيسي اتفاق
+
+903
+00:59:39,750 --> 00:59:39,830
+الرئيسي اتفاق الرئيسي اتفاق الرئيسي اتفاق الرئيسي
+
+904
+00:59:39,830 --> 00:59:42,730
+اتفاق الرئيسي اتفاق الرئيسي اتفاق الرئيسي اتفاق
+
+905
+00:59:42,730 --> 00:59:51,370
+الرئيسي اتفاق الرئيسي
+
+906
+00:59:51,370 --> 00:59:56,500
+اتفاقوالقانون المطلوبة للسلسلة، الامر الأساسي
+
+907
+00:59:56,500 --> 01:00:03,200
+للسلسلة مستخدم من قانون السلسلة للتجارب وربما
+
+908
+01:00:03,200 --> 01:00:06,880
+قرارًا من مصادرها إلى الحكومة التعامل معها عادة
+
+909
+01:00:06,880 --> 01:00:12,340
+تدفع هذه القانون لخيارات تجارب أو خيارات مختلفة
+
+910
+01:00:12,360 --> 01:00:16,700
+القانون التجارية التحقيقية القوة التحقيقية المشكلة
+
+911
+01:00:16,700 --> 01:00:17,380
+المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة
+
+912
+01:00:17,380 --> 01:00:17,780
+المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة
+
+913
+01:00:17,780 --> 01:00:19,740
+المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة
+
+914
+01:00:19,740 --> 01:00:20,520
+المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة
+
+915
+01:00:20,520 --> 01:00:21,780
+المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة
+
+916
+01:00:21,780 --> 01:00:21,820
+المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة
+
+917
+01:00:21,820 --> 01:00:22,360
+المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة
+
+918
+01:00:22,360 --> 01:00:24,320
+المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة
+
+919
+01:00:24,320 --> 01:00:34,740
+المشكلة المشكلThe term it's used to denote the
+
+920
+01:00:34,740 --> 01:00:40,080
+arbitrators sitting to determine the disparate
+
+921
+01:00:40,080 --> 01:00:44,100
+compensations of the arbitrator can vary
+
+922
+01:00:44,100 --> 01:00:50,820
+enormously with either a soleالتحريرين مع أو بدون
+
+923
+01:00:50,820 --> 01:00:56,200
+تأكيد وكثير من التعاملات مع بعضهم البعض في أكتر من
+
+924
+01:00:56,200 --> 01:01:02,500
+التحريكات والتحرير يستمتع بالانتقال من المساعدة
+
+925
+01:01:02,500 --> 01:01:08,050
+لأي شيء قمت أو فعلهLaw applicable to substance,
+
+926
+01:01:08,490 --> 01:01:12,090
+parties in a commercial dispute will often choose
+
+927
+01:01:12,090 --> 01:01:16,190
+the law applicable to the substance of their
+
+928
+01:01:16,190 --> 01:01:19,210
+dispute and in fact they are more likely to choose
+
+929
+01:01:19,210 --> 01:01:21,950
+substance .. substance .. okay I will talk about
+
+930
+01:01:21,950 --> 01:01:24,610
+for kids entertainment TV, I think everyone knows
+
+931
+01:01:24,610 --> 01:01:29,070
+about it, it's for animation .. for animeلتصنع
+
+932
+01:01:29,070 --> 01:01:36,110
+وتشريح المصادر على التليفزيون وكانت صفحة لتنهيئة
+
+933
+01:01:36,110 --> 01:01:44,570
+في هذا العام في 2012 صفحة لتنهيئة Chapter 11بعض ال
+
+934
+01:01:44,570 --> 01:01:48,370
+company four kids entertainment company known as
+
+935
+01:01:48,370 --> 01:01:52,110
+four kids is an American films and television
+
+936
+01:01:52,110 --> 01:01:58,430
+production company in bankruptcy since 2011 this
+
+937
+01:01:58,430 --> 01:02:03,270
+year it is known for English dubbing Japanese
+
+938
+01:02:03,270 --> 01:02:09,570
+animesوالخاصة في استخدام تصميم وتصميم التطبيقات
+
+939
+01:02:09,570 --> 01:02:14,610
+للأطفال في الانترنت وحول الولايات المتحدة وحول
+
+940
+01:02:14,610 --> 01:02:20,830
+العالم كالمجتمع فوركتز انترنت لديه مقاطع مخصصة في
+
+941
+01:02:20,830 --> 01:02:29,760
+الساعة السادسة في مدينة نيويورك ومشروع فوركتزوهو
+
+942
+01:02:29,760 --> 01:02:34,200
+مجتمعه في مبنى مختلفه في مانهاتون في نيويورك مجتمع
+
+943
+01:02:34,200 --> 01:02:40,100
+أسعار لطفولتهم NYSEKDA
+
+944
+01:02:40,100 --> 01:02:48,670
+في 1 يونيو 2010في 6 أبريل 2000 و 11 اتفال لـ
+
+945
+01:02:48,670 --> 01:02:53,470
+Chapter 11 Bankruptcy, Protection Following The
+
+946
+01:02:53,470 --> 01:02:57,590
+Lawsuit Concerning The UGF Franchise, it's an
+
+947
+01:02:57,590 --> 01:03:03,070
+animation that every one of us have watched since
+
+948
+01:03:03,070 --> 01:03:03,910
+we were kids
+
+949
+01:03:07,780 --> 01:03:11,440
+هي رقم مصادر الـ 4Kids ومصادره الـ 4Kids
+
+950
+01:03:11,440 --> 01:03:17,380
+Entertainment مصادر مختلفة من أجهزة التلفاز إلى
+
+951
+01:03:17,380 --> 01:03:21,680
+أجهزة التليفزيون إلى أجهزة الألعاب التي تدعم مصادر
+
+952
+01:03:21,680 --> 01:03:25,360
+الـ Royal Air Force 4Kids تركز على مصادر المحتوى
+
+953
+01:03:25,360 --> 01:03:27,380
+للأطفال ومعالم البريطانية
+
+954
+01:03:30,390 --> 01:03:35,090
+انها لطفان و فتاعتان كثير من مقالاتها تأتي من
+
+955
+01:03:35,090 --> 01:03:39,810
+مدخلات جيبانية أنمي مثلًا مثلًا مثلًا مثلًا مثلًا
+
+956
+01:03:39,810 --> 01:03:44,890
+مثلًا مثلًا
+
+957
+01:03:44,890 --> 01:03:52,130
+مثلًا
+
+958
+01:03:52,130 --> 01:03:56,410
+مثلًا مثلًا مثلًا
+
+959
+01:03:56,410 --> 01:03:58,950
+مثلًا
+
+960
+01:04:01,250 --> 01:04:07,030
+الـ CW of four kids الـ CW هي مجموعة من CBS و
+
+961
+01:04:07,030 --> 01:04:12,370
+Warner Brothers و Warner Brothers و CBS أعلنوا أن
+
+962
+01:04:12,370 --> 01:04:17,910
+الأطفال الـ WB و Warner Brothers كانوا برنامج
+
+963
+01:04:17,910 --> 01:04:22,790
+مجموعة مجموعة و لا يمكن أن يصنعوا أكتر من التلفاز
+
+964
+01:04:22,790 --> 01:04:26,790
+و المنزل و الأسلحة الكابلية بسبب مجموعة
+
+965
+01:04:31,440 --> 01:04:34,360
+مشكلة كبيرة كانت .. كانت .. كانت .. كانت .. كانت
+
+966
+01:04:34,360 --> 01:04:35,840
+.. كانت .. كانت .. كانت .. كانت .. كانت .. كانت ..
+
+967
+01:04:35,840 --> 01:04:40,860
+كانت .. كانت .. كانت .. كانت .. كانت .. كانت ..
+
+968
+01:04:40,860 --> 01:04:41,560
+كانت .. كانت .. كانت .. كانت .. كانت .. كانت ..
+
+969
+01:04:41,560 --> 01:04:41,600
+كانت .. كانت .. كانت .. كانت .. كانت .. كانت ..
+
+970
+01:04:41,600 --> 01:04:41,660
+كانت .. كانت .. كانت .. كانت .. كانت .. كانت ..
+
+971
+01:04:41,660 --> 01:04:41,760
+كانت .. كانت .. كانت .. كانت .. كانت .. كانت ..
+
+972
+01:04:41,760 --> 01:04:42,000
+كانت .. كانت .. كانت .. كانت .. كانت .. كانت ..
+
+973
+01:04:42,000 --> 01:04:50,620
+كانت .. كانت .. كانت .. كانت .. كانت .. كانت ..
+
+974
+01:04:50,620 --> 01:04:58,020
+كانت
+
+975
+01:04:58,020 --> 01:05:05,960
+.. كانو الوقت مع مجموعتهم الخاصة مع ال CBS والورنر
+
+976
+01:05:05,960 --> 01:05:13,900
+بروز أصبحوا 4 أطفال CW ال CBS و الورنر بروز و ال 4
+
+977
+01:05:13,900 --> 01:05:19,480
+أطفال ال 3 منهم مجموعة لتجمع .. لتجعل ال 5 ساعات
+
+978
+01:05:19,480 --> 01:05:26,080
+تصبح 9 ساعات .. ال 4 .. ال 4 ساعات ..4 طفل على
+
+979
+01:05:26,080 --> 01:05:33,860
+التلفاز و5 ساعة اضافية من شركة CBSCW تصبح 9 ساعة
+
+980
+01:05:33,860 --> 01:05:41,320
+تقوم بتصوير التلفاز على التلفاز 4 طفل وCW تغيروا
+
+981
+01:05:41,320 --> 01:05:48,400
+اسمهم لتصبح Tunzai بدأوا في أغسطس 2014 و2010
+
+982
+01:05:56,800 --> 01:06:06,380
+مثلًا تحتوي على دورميه المحيط وكل شخص لديه روبوت
+
+983
+01:06:06,380 --> 01:06:14,460
+لكل شخص ديناصور كينج و UGO 5D و UGO 6L و دراجون با
+
+984
+01:06:15,860 --> 01:06:20,180
+وهذه المصطلحات التي تصنعها الشركة مثل شايتك،
+
+985
+01:06:20,180 --> 01:06:24,860
+بوكيمون، وفيفا بناتا، الجميع يعرفها، خاصة فيفا
+
+986
+01:06:24,860 --> 01:06:25,800
+بناتا و بوكيمون
+
+987
+01:06:28,610 --> 01:06:35,130
+العامة الأساسية الـ UGO وانتجتها وانتجتها وانتجتها
+
+988
+01:06:35,130 --> 01:06:39,970
+وانتجتها
+
+989
+01:06:39,970 --> 01:06:41,530
+وانتجتها وانتجتها وانتجتها وانتجتها وانتجتها
+
+990
+01:06:41,530 --> 01:06:41,590
+وانتجتها وانتجتها وانتجتها وانتجتها وانتجتها
+
+991
+01:06:41,590 --> 01:06:41,830
+وانتجتها وانتجتها وانتجتها وانتجتها وانتجتها
+
+992
+01:06:41,830 --> 01:06:42,050
+وانتجتها وانتجتها وانتجتها وانتجتها وانتجتها
+
+993
+01:06:42,050 --> 01:06:46,770
+وانتجتها وانتجتها وانتجتها وانتجتها وانتجتها
+
+994
+01:06:46,770 --> 01:06:51,450
+وانتجتها و
+
+995
+01:06:52,180 --> 01:06:58,000
+وكانت الشركة تدخلت في اتفاق إيجابي مع شركات أخرى
+
+996
+01:06:58,000 --> 01:07:01,780
+وكانت تدخلت في إتفاق إيجابي مع شركات أخرى وكانت
+
+997
+01:07:01,780 --> 01:07:02,740
+إتفاق إيجابي مع شركات أخرى وكانت تدخلت في إتفاق
+
+998
+01:07:02,740 --> 01:07:04,000
+إيجابي مع شركات أخرى وكانت تدخلت في إتفاق إيجابي
+
+999
+01:07:04,000 --> 01:07:06,600
+مع شركات أخرى وكانت تدخلت في إتفاق إيجابي مع شركات
+
+1000
+01:07:06,600 --> 01:07:11,920
+أخرى وكانت تدخلت في إتفاق إيجابي مع شركات أخرى
+
+1001
+01:07:11,920 --> 01:07:17,480
+وكانت تدخلت في إتفاقام TV Tokyo بإعطائه لأطفال
+
+1002
+01:07:17,480 --> 01:07:21,340
+يجمعوا حقيقات بدون أن يدفعوا حصة من هذه الحقيقات
+
+1003
+01:07:21,340 --> 01:07:29,440
+لـ TV Tokyo وهو ما يخطر اتفاقاتهم الأصلية الشركات
+
+1004
+01:07:29,440 --> 01:07:34,120
+يحاولون حوالي 5 مليون دولار في تدفعاتهم
+
+1005
+01:07:35,870 --> 01:07:40,870
+الاعتبارات الخاطئة والاعتبارات غير مواجهة بشأن إذا
+
+1006
+01:07:40,870 --> 01:07:48,610
+قامت الشركات بإنهاء شركة UGO من فوركتز لأنها لا
+
+1007
+01:07:48,610 --> 01:07:54,930
+تصنعها بعد الانتهاء فوركتز قامت بالتحديد 11 تحديد
+
+1008
+01:07:54,930 --> 01:08:04,110
+الانفجار في 6 أبريل 2011 فوركتز طلبت من الحكومة أن
+
+1009
+01:08:04,110 --> 01:08:04,470
+تستخدم
+
+1010
+01:08:15,810 --> 01:08:20,950
+الشركة الوطنية اساتسو دي كيز هو شركة وطنية
+
+1011
+01:08:20,950 --> 01:08:28,570
+اليابانية تحاول تحكي تحكم الـ UGO فرنشيزية كل
+
+1012
+01:08:28,570 --> 01:08:33,610
+فرنشيزية حقوقية لتجعلها حقوقية في الولايات المتحدة
+
+1013
+01:08:35,140 --> 01:08:40,100
+وخصوصًا بالنسبة لسائق حقوق في السيريز الانمي
+
+1014
+01:08:40,100 --> 01:08:46,580
+الأخير عامًا زيكسال هو الانمي الأخير وكان يستمر في
+
+1015
+01:08:46,580 --> 01:08:49,920
+موضوع الفرنشيز الانتقالية التي كانت بسبب الواجهة
+
+1016
+01:08:49,920 --> 01:08:56,820
+في مجلس الانتقال الأمريكي الانتقالي على 14 يوليو
+
+1017
+01:08:58,630 --> 01:09:04,090
+الشركة .. الشرطة اتخذت .. اتخذت .. اتخذت اتخذت
+
+1018
+01:09:04,090 --> 01:09:12,130
+اتخذت اتخذت اتخذت اتخذت اتخذت اتخذت اتخذت اتخذت
+
+1019
+01:09:12,130 --> 01:09:15,090
+اتخذت اتخذت اتخذت اتخزت اتخزت اتخزت اتخزت اتخزت
+
+1020
+01:09:15,090 --> 01:09:15,990
+اتخزت اتخزت اتخزت اتخزت اتخزت اتخزت اتخزت اتخزت
+
+1021
+01:09:15,990 --> 01:09:24,160
+اتخزت اتخزت اتخزت اتخزت اتخزت اتخزت اتخوهو إذا
+
+1022
+01:09:24,160 --> 01:09:30,140
+كانت مجموعة ومجموعة صحيحة، وإذا كانت الشركة يجب أن
+
+1023
+01:09:30,140 --> 01:09:35,480
+تدفع كل شيء لدفعها لدفع شركة TV Tokyo، الشركة
+
+1024
+01:09:35,480 --> 01:09:45,330
+الأصلية، وفترة أولى بدأت في هذا العام، في أغسطسبنك
+
+1025
+01:09:45,330 --> 01:09:50,490
+فلسطين بنك فلسطين هو أول و أكبر بنك أمريكي وكان
+
+1026
+01:09:50,490 --> 01:09:55,770
+مؤسسا في 1960 وبدأت عملية عملية عملية عملية عملية
+
+1027
+01:09:55,770 --> 01:09:56,450
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+1028
+01:09:56,450 --> 01:09:56,650
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+1029
+01:09:56,650 --> 01:09:57,510
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+1030
+01:09:57,510 --> 01:09:57,790
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+1031
+01:09:57,790 --> 01:10:01,170
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+1032
+01:10:01,170 --> 01:10:10,610
+عملية عملية عملية عملية عملية عملية عملية
+
+1033
+01:10:10,610 --> 01:10:17,630
+عبنك فلسطين هو أكثر مهمة في فلسطين من خلال نتوارك
+
+1034
+01:10:17,630 --> 01:10:25,750
+البنك يتجاوز من 45 قطع وقطع أخرى من جنين إلى رفح
+
+1035
+01:10:25,750 --> 01:10:32,290
+وصحبتها البنك فلسطين لديه عمليات ممتازة وموظفين
+
+1036
+01:10:32,290 --> 01:10:37,350
+عالميا في البنك لديه أكتر من ألف شخص
+
+1037
+01:10:41,620 --> 01:10:45,320
+توفر العديد من المساعدات التحقيقية التي تتجاوز
+
+1038
+01:10:45,320 --> 01:10:49,960
+احتجاز المستخدم والتوقع تحتوي على مصادر وشركات
+
+1039
+01:10:49,960 --> 01:10:55,260
+وشركات وشركات وشركات وشركات وشركات وشركات وشركات
+
+1040
+01:10:55,260 --> 01:10:55,420
+وشركات وشركات وشركات وشركات وشركات وشركات وشركات
+
+1041
+01:10:55,420 --> 01:10:55,720
+وشركات وشركات وشركات وشركات وشركات وشركات وشركات
+
+1042
+01:10:55,720 --> 01:10:57,420
+وشركات وشركات وشركات وشركات وشركات وشركات وشركات
+
+1043
+01:10:57,420 --> 01:11:05,700
+وشركات وشركات وشركات وشركات وشركات وشركات وشركات
+
+1044
+01:11:05,700 --> 01:11:13,430
+وشركات وشركاتالبنك الفلسطيني عرضت هذه السنة جوال
+
+1045
+01:11:13,430 --> 01:11:20,990
+في جوبيلي على موقع .. جوبيلي على موقع مرحلة 50 سنة
+
+1046
+01:11:20,990 --> 01:11:26,910
+من مؤسسته تحت السلوكان 50 سنة من بناء البنك تم
+
+1047
+01:11:26,910 --> 01:11:33,510
+تسمح بالمحافظة الفلسطينية في عام 2005 كمحافظة عام
+
+1048
+01:11:33,510 --> 01:11:41,000
+2006بنك فلسطين قامت ببناء شركة الوساطة لأستخدام
+
+1049
+01:11:41,000 --> 01:11:42,860
+الحماية الوساطة الوساطة الوساطة الوساطة الوساطة
+
+1050
+01:11:42,860 --> 01:11:43,360
+الوساطة الوساطة الوساطة الوساطة الوساطة الوساطة
+
+1051
+01:11:43,360 --> 01:11:44,520
+الوساطة الوساطة الوساطة الوساطة الوساطة الوساطة
+
+1052
+01:11:44,520 --> 01:11:47,180
+الوساطة الوساطة
+
+1053
+01:11:48,710 --> 01:11:55,770
+في فترة قصيرة، تصبح الشركة الأولى للإزالة،
+
+1054
+01:11:55,770 --> 01:12:01,010
+فإن رقم المحافظات افتتحت، والثالثة بالنسبة للتداول
+
+1055
+01:12:01,010 --> 01:12:05,930
+بين ال 10 شركات التجارب الموجودة في بلستين
+
+1056
+01:12:10,480 --> 01:12:16,040
+مليون يو اس دولار 120 مليون يو اس دولار قبلت
+
+1057
+01:12:16,040 --> 01:12:21,480
+كبيتال بعد تقليل 20 مليون يو اس دولار من المال
+
+1058
+01:12:21,480 --> 01:12:25,080
+الخاص بالمحافظة في ميو 2011
+
+1059
+01:12:28,160 --> 01:12:30,640
+البنك لديه اكتشاف اكتشاف أكتشاف أكتشاف أكتشاف
+
+1060
+01:12:30,640 --> 01:12:32,520
+أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف
+
+1061
+01:12:32,520 --> 01:12:36,720
+أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف
+
+1062
+01:12:36,720 --> 01:12:42,220
+أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف
+
+1063
+01:12:42,220 --> 01:12:45,660
+أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف
+
+1064
+01:12:45,660 --> 01:12:45,740
+أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف
+
+1065
+01:12:45,740 --> 01:12:52,820
+أكتشاف أكتشاف أكتشاف
+
+1066
+01:12:52,820 --> 01:12:59,820
+أكأسعار التحديات البلستانية يظهر بأن بنك البلستاني
+
+1067
+01:12:59,820 --> 01:13:06,860
+بدأ التجارب في نوفمبر 2005 أعلى السعر كان 6.75
+
+1068
+01:13:06,860 --> 01:13:15,220
+دولار الأمريكي في 2005 وهو مجموعة وإضافة في أسعار
+
+1069
+01:13:15,220 --> 01:13:16,460
+التحديات البلستانية
+
+1070
+01:13:24,170 --> 01:13:30,790
+2.5 دولار الأمريكي 2.5 دولار الأمريكي It was most
+
+1071
+01:13:30,790 --> 01:13:35,650
+volatile in 2007 with the difference between the
+
+1072
+01:13:35,650 --> 01:13:41,570
+annual low and high prices reaching 3.54 US dollar
+
+1073
+01:13:41,570 --> 01:13:51,750
+and nowadaysأنا أرى في الوصفة الوساطة الوصفة
+
+1074
+01:13:51,750 --> 01:13:54,690
+الوساطة الوصفة الوصفة الوصفة الوصفة الوصفة الوصفة
+
+1075
+01:13:54,690 --> 01:14:01,330
+الوصفة الوصفة الوصفة الوصفة الوصفة الوصفة الوصفة
+
+1076
+01:14:02,210 --> 01:14:09,190
+الوضع الاقتصادي تأثير على المصطلح والمصطلح قام
+
+1077
+01:14:09,190 --> 01:14:17,250
+بتجاربه 10 مليون دولار تقريبا
+
diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/Hja0vbDM124_raw.srt b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/Hja0vbDM124_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..7f469af58f54a1b6436a94205ac3b1f9299c5ffa
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/Hja0vbDM124_raw.srt
@@ -0,0 +1,4492 @@
+1
+00:00:13,900 --> 00:00:17,440
+Okay السلام عليكم this is the second lecture on
+
+2
+00:00:17,440 --> 00:00:21,060
+bankruptcy bankruptcy
+
+3
+00:00:21,060 --> 00:00:24,640
+we have in general we have liquidation and
+
+4
+00:00:24,640 --> 00:00:29,360
+reorganizationبعض النقطة التي يجب أن ننظر إليها و
+
+5
+00:00:29,360 --> 00:00:33,260
+نتكلم عنها عندما نتكلم عن الانهيار و الانهيار
+
+6
+00:00:33,260 --> 00:00:38,260
+عندما نتكلم عن الانهيار و الانهيار عندما نتكلم عن
+
+7
+00:00:38,260 --> 00:00:38,840
+الانهيار و الانهيار عندما نتكلم عن الانهيار و
+
+8
+00:00:38,840 --> 00:00:39,040
+الانهيار عندما نتكلم عن الانهيار و الانهيار عندما
+
+9
+00:00:39,040 --> 00:00:39,440
+نتكلم عن الانهيار و الانهيار عندما نتكلم عن
+
+10
+00:00:39,440 --> 00:00:39,500
+الانهيار و الانهيار عندما نتكلم عن الانهيار و
+
+11
+00:00:39,500 --> 00:00:41,200
+الانهيار عندما نتكلم عن الانهيار و الانهيار عندما
+
+12
+00:00:41,200 --> 00:00:42,600
+نتكلم عن الانهيار و الانهيار عندما نتكلم عن
+
+13
+00:00:42,600 --> 00:00:55,680
+الانهيار و الانهيار عند
+
+14
+00:00:55,890 --> 00:01:00,430
+والإيقاع كما ترى أننا لدينا الأموال المفروضة
+
+15
+00:01:00,430 --> 00:01:08,490
+والأموال المفروضة الأموال المفروضة لا الأموال
+
+16
+00:01:08,490 --> 00:01:14,410
+المفروضة يجب أن تتم اختيارها من البياناتنحن لدينا
+
+17
+00:01:14,410 --> 00:01:18,450
+أموال مفروضة و لا اموال مفروضة يجب أن نبقى الأموال
+
+18
+00:01:18,450 --> 00:01:24,030
+المفروضة المال المنزل كل شيء يجب أن يكون هنا
+
+19
+00:01:24,030 --> 00:01:28,850
+لإحتجاز المال والعائلة لديه يجب أن نبقى يجب أن
+
+20
+00:01:28,850 --> 00:01:33,390
+نغادر أي شيء أكتر يجب أن نأخذه وهو ما يسمى أموال
+
+21
+00:01:33,390 --> 00:01:38,170
+لا مفروضة يجب أن نأخذه يجب أن نسحب ويجب أن نقوم
+
+22
+00:01:38,170 --> 00:01:42,810
+بتقاط المال بين المستخدمين لدينا المال يجب أن نركز
+
+23
+00:01:42,810 --> 00:01:43,110
+على
+
+24
+00:01:56,160 --> 00:02:01,920
+والاستثمارات الانتجارية الانتجارية
+
+25
+00:02:01,920 --> 00:02:13,820
+تصفية تصفية
+
+26
+00:02:13,820 --> 00:02:14,660
+تصفية تصفية تصفية تصفية تصفية تصفية تصفية تصفية
+
+27
+00:02:14,660 --> 00:02:14,740
+تصفية تصفية تصفية تصفية تصفية تصفية تصفية تصفية
+
+28
+00:02:14,740 --> 00:02:14,740
+تصفية تصفية تصفية تصفية تصفية تصفية تصفية تصفية
+
+29
+00:02:14,740 --> 00:02:14,740
+تصفية تصفية تصفية تصفية تصفية تصفية تصفية تصفية
+
+30
+00:02:14,740 --> 00:02:14,760
+تصفية تصفية تصفية تصفية تصفية تصفية تصفية تصفية
+
+31
+00:02:14,760 --> 00:02:17,800
+تصفية تصفية تصفية تصفية تصفية تصفية تصفية تصفية
+
+32
+00:02:17,800 --> 00:02:21,460
+تصفية
+
+33
+00:02:22,340 --> 00:02:25,940
+including the cash, the car, the house, the land
+
+34
+00:02:25,940 --> 00:02:29,780
+everything you have which is none exempted which
+
+35
+00:02:29,780 --> 00:02:33,300
+is none protected none exempted assets something
+
+36
+00:02:33,300 --> 00:02:36,240
+extra money you have extra money more than you
+
+37
+00:02:36,240 --> 00:02:39,020
+need for your basic life we have to take it away
+
+38
+00:02:39,020 --> 00:02:42,860
+and then we have to sell we take the money and
+
+39
+00:02:42,860 --> 00:02:46,020
+then we divide it between creditors and number
+
+40
+00:02:46,020 --> 00:02:51,380
+three number one okay number three is you have to
+
+41
+00:02:51,380 --> 00:02:57,320
+pay the moneyمال المال اللي لديك ومال المال اللي
+
+42
+00:02:57,320 --> 00:02:59,240
+لديك ومال المال اللي لديك ومال المال اللي لديك
+
+43
+00:02:59,240 --> 00:02:59,240
+ومال المال اللي لديك ومال المال اللي لديك ومال
+
+44
+00:02:59,240 --> 00:02:59,260
+المال اللي لديك ومال المال اللي لديك ومال المال
+
+45
+00:02:59,260 --> 00:02:59,960
+اللي لديك ومال المال اللي لديك ومال المال اللي
+
+46
+00:02:59,960 --> 00:03:01,240
+لديك ومال المال اللي لديك ومال المال اللي لديك
+
+47
+00:03:01,240 --> 00:03:01,260
+ومال المال اللي لديك ومال المال اللي لديك ومال
+
+48
+00:03:01,260 --> 00:03:01,260
+المال اللي لديك ومال المال اللي لديك ومال المال
+
+49
+00:03:01,260 --> 00:03:02,460
+اللي لديك ومال المال اللي لديك ومال المال اللي
+
+50
+00:03:02,460 --> 00:03:06,260
+لديك ومال المال اللي لديك ومال المال اللي لديك
+
+51
+00:03:06,260 --> 00:03:22,300
+ومال
+
+52
+00:03:22,300 --> 00:03:28,150
+المالوهو يسمى اتجارة اتجارة
+
+53
+00:03:28,150 --> 00:03:35,710
+اتجارة اتجارة اتجارة اتجارة اتجارة اتجارة اتجارة
+
+54
+00:03:35,710 --> 00:03:39,070
+اتجارة
+
+55
+00:03:39,070 --> 00:03:49,570
+اتجارة اتجارة
+
+56
+00:03:49,850 --> 00:03:52,290
+نشوف هذا في الولايات المتحدة و الUSA و كم وقت
+
+57
+00:03:52,290 --> 00:03:58,110
+تستخدمه من الوقت اللي لدينا بانكروبسي order لدينا
+
+58
+00:03:58,110 --> 00:04:01,770
+بانكروبسي order هذه .. عندما نحصل على هذه القرارة
+
+59
+00:04:01,770 --> 00:04:05,190
+فهي مجرد قرار بانكروبسي order إنها قرارة، إنها
+
+60
+00:04:05,190 --> 00:04:08,890
+قرار أخير ثم تصبحين بانكروبت و عندما تصبحين
+
+61
+00:04:08,890 --> 00:04:14,150
+بانكروبت فهي قصة مختلفة تماما، ليس مثل ديتر، ديتر
+
+62
+00:04:14,150 --> 00:04:20,580
+ليس مثل بانكروبتمفلس still you might take more
+
+63
+00:04:20,580 --> 00:04:24,500
+steps to be a bankrupt you can be a debtor but you
+
+64
+00:04:24,500 --> 00:04:29,340
+can pay the debts sometimes .. sometimes you can
+
+65
+00:04:29,340 --> 00:04:35,220
+be in debt but you can pay and you are in due to
+
+66
+00:04:35,220 --> 00:04:39,330
+pay the money and you pay them on timeفي هذه
+
+67
+00:04:39,330 --> 00:04:42,530
+الحالة هنا فلا أحد يستطيع أن يطلب منك انتصارك
+
+68
+00:04:42,530 --> 00:04:46,010
+يمكنك أن تبقى في عملك ولكن عندما تتوقف هنا عندما
+
+69
+00:04:46,010 --> 00:04:50,490
+تتوقف لا يمكنك أن تدفع الأموال بعد الأن لا يمكنك
+
+70
+00:04:50,490 --> 00:04:53,450
+أن تأخذ اي خطوط أكتر لدفع مالك لك ثم نستطيع أن
+
+71
+00:04:53,450 --> 00:04:57,590
+نطلب منك انتصارك ، لذلك الاحتياطات مفتوحة من
+
+72
+00:04:57,590 --> 00:05:05,210
+المستخدمين المفتوحين هنا مع وقت ووانتج اعتبارات
+
+73
+00:05:05,210 --> 00:05:13,110
+صحيحة و صحيحة اعتبارات صحيحة اعتبارات
+
+74
+00:05:13,110 --> 00:05:14,370
+صحيحة اعتبارات صحيحة اعتبارات صحيحة اعتبارات صحيحة
+
+75
+00:05:14,370 --> 00:05:16,510
+اعتبارات صحيحة اعتبارات صحيحة اعتبارات صحيحة
+
+76
+00:05:16,510 --> 00:05:16,610
+اعتبارات صحيحة اعتبارات صحيحة اعتبارات صحيحة
+
+77
+00:05:16,610 --> 00:05:16,610
+اعتبارات صحيحة اعتبارات صحيحة اعتبارات صحيحة
+
+78
+00:05:16,610 --> 00:05:17,090
+اعتبارات صحيحة اعتبارات صحيحة اعتبارات صحيحة
+
+79
+00:05:17,090 --> 00:05:20,990
+اعتبارات صحيحة اعتبارات
+
+80
+00:05:20,990 --> 00:05:31,950
+صحيحة اعتبارات صحيحة اعتبار
+
+81
+00:05:34,410 --> 00:05:37,010
+هو قريب من أن يكون مغامر و يكون لدينا سؤال في
+
+82
+00:05:37,010 --> 00:05:42,390
+السجن ثم اني أعطى رواية وقت محدد ووقت محدد لجميع
+
+83
+00:05:42,390 --> 00:05:46,330
+المستخدمين الذين يقابلوا في هذه الحالة اذا كان
+
+84
+00:05:46,330 --> 00:05:50,130
+لديهم أمر مغامر مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+85
+00:05:50,130 --> 00:05:51,090
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+86
+00:05:51,090 --> 00:05:51,590
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+87
+00:05:51,590 --> 00:06:03,210
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجر
+
+88
+00:06:03,860 --> 00:06:07,480
+وانت لم تقوم بمشاركة تلك المصادر فسيخسر مالك حتى
+
+89
+00:06:07,480 --> 00:06:10,440
+اذا كان لديك مثلا دعنا نقول ان انا مات من خلال نصف
+
+90
+00:06:10,440 --> 00:06:17,060
+مليون دولار وكل ما انا لدي اليوم 150 ألف دولار ثم
+
+91
+00:06:17,060 --> 00:06:22,000
+السجن سيأخذ المال و يقوم بتقسيمه بين 9 مصادر ولكن
+
+92
+00:06:22,000 --> 00:06:25,660
+اذا واحد لم يقوم بمشاركة المصادر فكان مغضب ولم
+
+93
+00:06:25,660 --> 00:06:30,320
+يعرف ولم يتبع هذا هو مشكلته الخاصة لنا لا يهم إذا
+
+94
+00:06:30,320 --> 00:06:33,730
+لم يقوم بمشاركة المصادر على وقتثم لا يستطيع أن
+
+95
+00:06:33,730 --> 00:06:37,190
+يأتي لاحقا و يقول انا نسيت انا لم اطلب مالي اريد
+
+96
+00:06:37,190 --> 00:06:39,750
+مالي اريد قطعة من المال اللي اريد مالي اريد مالي
+
+97
+00:06:39,750 --> 00:06:42,370
+قطعة من المال اللي اريد مالي مالي مالي مالي مالي
+
+98
+00:06:42,370 --> 00:06:42,370
+مالي مالي مالي مالي مالي مالي مالي مالي مالي مالي
+
+99
+00:06:42,370 --> 00:06:42,370
+مالي مالي مالي مالي مالي مالي مالي مالي مالي مالي
+
+100
+00:06:42,370 --> 00:06:42,550
+مالي مالي مالي مالي مالي مالي مالي مالي مالي مالي
+
+101
+00:06:42,550 --> 00:06:42,590
+مالي مالي مالي مالي مالي مالي مالي مالي مالي مالي
+
+102
+00:06:42,590 --> 00:06:51,910
+مالي مالي مالي مالي مالي مال
+
+103
+00:06:51,950 --> 00:06:58,290
+واضح وليس مقارنة مثلا انا كنت في عقد ل 10 اشخاص و
+
+104
+00:06:58,290 --> 00:07:03,010
+الأن ليس لدينا مقارنة عن هذا ثم المال يجب أن يكون
+
+105
+00:07:03,010 --> 00:07:09,570
+مقاطع على نظام يسمى راتب
+
+106
+00:07:09,570 --> 00:07:17,190
+بي برسنتج المال الأموات تلك الأموات اللي ليست
+
+107
+00:07:17,190 --> 00:07:23,400
+مجالية للعقد اللي تم تجمعهايمكن أن تتسوق منها،
+
+108
+00:07:23,400 --> 00:07:29,000
+نأخذ المال و نقوم بتقاطه بين المستخدمين على نظام
+
+109
+00:07:29,000 --> 00:07:34,720
+يسمى بروراتن، percentage لأنه ليس فرصة أن يكون
+
+110
+00:07:34,720 --> 00:07:38,620
+لديك مستخدم واحد بميزة 50 ألف ومستخدم واحد بميزة
+
+111
+00:07:38,620 --> 00:07:43,840
+10 ألف يحصل على نفس المال، لا، فهو مصمم من كم
+
+112
+00:07:43,840 --> 00:07:48,490
+المال الذي ستحصل عليه، كم المال الذي ستستخدمهالشخص
+
+113
+00:07:48,490 --> 00:07:52,490
+المالي يستطيع أن يقوم بتقليل المال عن ذلك ويوجد
+
+114
+00:07:52,490 --> 00:07:57,830
+أشياء مختلفة يجب أن نذكرها هنا حتى لو قمنا بتقليل
+
+115
+00:07:57,830 --> 00:08:03,010
+المال وقمنا بتقليل المال بين المستخدمين لدينا
+
+116
+00:08:03,010 --> 00:08:10,650
+أوليات بين المأمن والمأمن هنا مأمن و
+
+117
+00:08:13,810 --> 00:08:16,710
+Look at this in the exam, this is so important, we
+
+118
+00:08:16,710 --> 00:08:19,470
+have two types of creditors, one of them is called
+
+119
+00:08:19,470 --> 00:08:22,910
+secured and the second is unsecured, most
+
+120
+00:08:22,910 --> 00:08:26,970
+creditors, most of them are unsecured, which we
+
+121
+00:08:26,970 --> 00:08:30,350
+call them general creditors, unsecured, then you
+
+122
+00:08:30,350 --> 00:08:34,970
+don't have something guaranteed, those secured
+
+123
+00:08:34,970 --> 00:08:39,770
+creditors, they have guarantees, فيه ضمنانهي ممكن
+
+124
+00:08:39,770 --> 00:08:42,330
+تكون السيارة، ممكن تكون المنزل، ممكن تكون المال،
+
+125
+00:08:42,330 --> 00:08:46,030
+هم لديهم بعض التأكيدات، لكن بعد ذلك، ما يجب أن
+
+126
+00:08:46,030 --> 00:08:48,210
+نفعله في هذا، نحن لدينا المال، ماذا نستطيع أن نفعل
+
+127
+00:08:48,210 --> 00:08:52,490
+بهذا؟ إذا كان لدينا أولوية، من يمكن أن ندفع أولا؟
+
+128
+00:08:52,490 --> 00:08:57,250
+الأمان، ومال يبقى خلفه يمكن أن يكون مقاطع بين
+
+129
+00:08:57,250 --> 00:09:04,140
+المستثمرين الأمانية، فأولا يجب أن ندفع الأمانالمال
+
+130
+00:09:04,140 --> 00:09:06,580
+المتبقى بعد ذلك إذا كان لدينا او اثنين من
+
+131
+00:09:06,580 --> 00:09:08,440
+المستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+132
+00:09:08,440 --> 00:09:08,680
+مستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+133
+00:09:08,680 --> 00:09:08,700
+مستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+134
+00:09:08,700 --> 00:09:10,120
+مستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+135
+00:09:10,120 --> 00:09:11,440
+مستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+136
+00:09:11,440 --> 00:09:14,120
+مستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+137
+00:09:14,120 --> 00:09:14,180
+مستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+138
+00:09:14,180 --> 00:09:21,680
+مستخدمين مستخدمين مستخدمين مستخدمين
+
+139
+00:09:21,680 --> 00:09:31,780
+مستخدمين
+
+140
+00:09:34,290 --> 00:09:38,570
+في حالة مختلفة، لدينا تحويل، وهذا يسمى في الولايات
+
+141
+00:09:38,570 --> 00:09:45,530
+المتحدة Voluntary V Voluntary Arrangement بين
+
+142
+00:09:45,530 --> 00:09:50,290
+الاتجاهين، سننظر إلى ذلك لاحقًا، ولكن في تحويل
+
+143
+00:09:50,290 --> 00:09:55,090
+الانفجار، إنه تمامًا عكس ما لدينا في الاستخدام، في
+
+144
+00:09:55,090 --> 00:10:00,030
+الاستخدام نحن نستخدم، نخلق العمل، ولكن هنا لا
+
+145
+00:10:00,030 --> 00:10:03,930
+يمكنك أن تستمربقى موجودا , يمكنك أن تفعل عملك
+
+146
+00:10:03,930 --> 00:10:06,310
+الخاص بيبقى موجودا و تستمتع بعملك الخاص بيبقى
+
+147
+00:10:06,310 --> 00:10:09,230
+موجودا و تستمتع بعملك الخاص بيبقى موجودا و تستمتع
+
+148
+00:10:09,230 --> 00:10:10,750
+بعملك الخاص بيبقى موجودا و تستمتع بعملك الخاص
+
+149
+00:10:10,750 --> 00:10:13,910
+بيبقى موجودا و تستمتع بعملك الخاص بيبقى موجودا و
+
+150
+00:10:13,910 --> 00:10:17,090
+تستمتع بعملك الخاص بيبقى موجودا و تستمتع بعملك
+
+151
+00:10:17,090 --> 00:10:19,890
+الخاص بيبقى موجودا و تستمتع بعملك الخاص بيبقى
+
+152
+00:10:19,890 --> 00:10:27,230
+موجودا و تستمتع بعملك الخاص بيبقى موجودا
+
+153
+00:10:27,230 --> 00:10:32,950
+و تستمتع بعملك الخاص بيبقI would pay only what I
+
+154
+00:10:32,950 --> 00:10:37,910
+have in liquidation if I have only 10% of what I'm
+
+155
+00:10:37,910 --> 00:10:40,890
+supposed to pay then I would pay the 10% and the
+
+156
+00:10:40,890 --> 00:10:46,450
+90% no one can ask me once I have a discharge in
+
+157
+00:10:46,450 --> 00:10:49,610
+the future no one can ask me nothing even if I
+
+158
+00:10:49,610 --> 00:10:51,810
+become a multimillionaire once you have a
+
+159
+00:10:51,810 --> 00:10:57,130
+discharge you have it means freedom relief a new
+
+160
+00:10:57,130 --> 00:11:03,240
+life can forget about the past leave itNow in this
+
+161
+00:11:03,240 --> 00:11:05,420
+situation as you can see that we can keep the
+
+162
+00:11:05,420 --> 00:11:10,220
+assets, we can keep the business and we have to
+
+163
+00:11:10,220 --> 00:11:12,860
+pay the full amount of money, but in this case we
+
+164
+00:11:12,860 --> 00:11:20,380
+have a new time notice, we have to have the money
+
+165
+00:11:20,380 --> 00:11:25,960
+to satisfy creditors claim, it's called إعادة
+
+166
+00:11:25,960 --> 00:11:30,770
+الجدولةو إذا كنت مالك و أجب أن أدفع نصف مليون لعمل
+
+167
+00:11:30,770 --> 00:11:33,390
+ولكن ليس لدي المال، فيمكنك أن تعطيني ملاحظة،
+
+168
+00:11:33,390 --> 00:11:36,950
+الوقت، هذا سيكون خمس سنوات أو خمس سنوات أو ثلاث
+
+169
+00:11:36,950 --> 00:11:41,370
+سنوات، فهذا يعتمد على المادة المالية، ثم خلال ذلك
+
+170
+00:11:41,370 --> 00:11:46,350
+الوقت سأكون قادر على أن أدفع المادة المالية. الآن،
+
+171
+00:11:46,350 --> 00:11:51,250
+بعض الناس يريدون أن يكونوا مستخدينين، و لا يريدون
+
+172
+00:11:51,250 --> 00:11:54,630
+أن يكونوا مستخدينين الأخرينلأن في المحافظة، أعني
+
+173
+00:11:54,630 --> 00:11:59,670
+في التعامل هنا، نحن نعيش .. نعيش من الانسلفات،
+
+174
+00:11:59,670 --> 00:12:08,870
+لسنا لدينا المحافظة هنا في التعامل، نحن نعيش من
+
+175
+00:12:08,870 --> 00:12:12,910
+الانسلفات، نحن نعيش من المحافظة، نستطيع أن نبقى في
+
+176
+00:12:12,910 --> 00:12:17,590
+عملنا، نستطيع أن نستمر في ذلك، نستطيع هنا و نستطيع
+
+177
+00:12:17,590 --> 00:12:22,110
+أن نكون حمايةنحن نستطيع أن نكون حماية من أي إدعاء،
+
+178
+00:12:22,110 --> 00:12:24,190
+فالوحيء اللي يمكنك أن تحصل عليه مالك إذا كان لديك
+
+179
+00:12:24,190 --> 00:12:30,810
+مؤسسة مرتبطة مرة أخرى هو الحكومة، إنها قناة جديدة،
+
+180
+00:12:30,810 --> 00:12:33,690
+إنها الطريقة الوحيدة التي يمكنك أن تكون فيها مؤسسة
+
+181
+00:12:33,690 --> 00:12:37,150
+مرتبطة مرة أخرى لأن هنا نحن لدينا خطة، وهذه الخطة،
+
+182
+00:12:37,150 --> 00:12:43,500
+نحن لدينا اقتراحفي هذه التطبيقه، كدتر، كنت دتر من
+
+183
+00:12:43,500 --> 00:12:47,200
+نصف مليون دولار، أستطيع أن أقدم تطبيقه يقول أنه
+
+184
+00:12:47,200 --> 00:12:51,480
+يمكنني أن أدفعك المال، ولكن يحتاج 2 سنة، لكن يجب
+
+185
+00:12:51,480 --> 00:12:55,240
+أن أحدث في التطبيق كم المال يمكنني أن أدفعه كل
+
+186
+00:12:55,240 --> 00:12:59,820
+أشهرand I can specify how can I get the money and
+
+187
+00:12:59,820 --> 00:13:03,400
+I would state some guarantees because if I cannot
+
+188
+00:13:03,400 --> 00:13:05,120
+pay the money they would take it from the
+
+189
+00:13:05,120 --> 00:13:08,320
+guarantees so this stage here in this way
+
+190
+00:13:08,320 --> 00:13:12,200
+reorganization it's not easy to happen quite often
+
+191
+00:13:12,200 --> 00:13:14,100
+people have liquidation they don't have
+
+192
+00:13:14,100 --> 00:13:17,520
+reorganization reorganization will have guarantees
+
+193
+00:13:17,520 --> 00:13:20,680
+في ضمنانwe have guarantees, we have money to be
+
+194
+00:13:20,680 --> 00:13:23,040
+paid, we have somebody to stay in business, so we
+
+195
+00:13:23,040 --> 00:13:26,780
+have to make sure that everything I have stated in
+
+196
+00:13:26,780 --> 00:13:30,380
+the plan is correct and I will have the guarantees
+
+197
+00:13:30,380 --> 00:13:33,660
+and I will have the sponsors so if I don't pay my
+
+198
+00:13:33,660 --> 00:13:38,020
+sponsor اللي هو ال .. what sponsor؟ الضامن he
+
+199
+00:13:38,020 --> 00:13:44,300
+would be instead of meعندما أفعل كل هذا، لا أحد
+
+200
+00:13:44,300 --> 00:13:48,160
+يستطيع أن يطلب مني أن أكون حماية حسنًا، أعطيت نفسي
+
+201
+00:13:48,160 --> 00:13:54,020
+وعد، أنني سأدفعك، حسنًا، سأدفعك، ثم لن تطلب مني
+
+202
+00:13:54,020 --> 00:13:58,180
+مرة أخرى، عليك أن تنتظر حركتك حتى تحصل على المال،
+
+203
+00:13:58,180 --> 00:14:01,100
+ولا أحد أخر يستطيع أن يفعل هذا هنا، البيانات
+
+204
+00:14:01,100 --> 00:14:06,970
+حماية، حماية من ماذا؟معظم حكومات عملية تجارب غير
+
+205
+00:14:06,970 --> 00:14:12,950
+تجارب لا يستطيعون تحقيق أكتر نوع من الحكومات، كل
+
+206
+00:14:12,950 --> 00:14:16,850
+شيء مفرزن، سأجب أن أدفعك، ولكن بداخل الأنظمة،
+
+207
+00:14:16,850 --> 00:14:20,670
+بداخل الأنظمة، بعض الناس يفكرون في تجارب تجارب
+
+208
+00:14:20,670 --> 00:14:22,170
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+209
+00:14:22,170 --> 00:14:22,650
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+210
+00:14:22,650 --> 00:14:23,710
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+211
+00:14:23,710 --> 00:14:31,030
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+212
+00:14:31,030 --> 00:14:34,570
+ت
+
+213
+00:14:34,880 --> 00:14:41,260
+مثلًا تخيل نفسك .. نعم لكن تخيل نفسك كيف .. هل هو
+
+214
+00:14:41,260 --> 00:14:46,420
+جيد أو سيء؟ أنت كدتر في السوق تخيل أنك اليوم مالك
+
+215
+00:14:46,420 --> 00:14:49,420
+و نصف مليون أو اتون مليون باونز لأننا نتكلم عن
+
+216
+00:14:49,420 --> 00:14:52,360
+شركات و أشخاص من الشباب اللي يستخدمون الكثير من
+
+217
+00:14:52,360 --> 00:14:56,240
+المال انت مالك اتون اتون مليون اتون مليون باونز و
+
+218
+00:14:56,240 --> 00:14:58,280
+بعد ذلك لديك 15 مالين مالين مالين مالين مالين
+
+219
+00:14:58,280 --> 00:14:58,960
+مالين مالين مالين مالين مالين مالين مالين مالين
+
+220
+00:14:58,960 --> 00:14:59,360
+مالين مالين مالين مالين مالين مالين مالين مالين
+
+221
+00:14:59,360 --> 00:15:00,310
+مالين مالين مالين مالين مالين مالين مالين مالين مو
+
+222
+00:15:00,310 --> 00:15:04,170
+كل يوم انت في الحكمة تتجارب عليهم و تقول انهم
+
+223
+00:15:04,170 --> 00:15:07,250
+يطلبون منك أن تدفع المال و لا يمكنك أن تدفع المال،
+
+224
+00:15:07,250 --> 00:15:11,070
+ربما تكون في حجة، ماذا يجب أن تفعل؟ و فجأة تجد
+
+225
+00:15:11,070 --> 00:15:17,810
+حلوة، حلوة مجنونة، حلوة مجنونة تقول هنا بإن فجأة
+
+226
+00:15:17,810 --> 00:15:19,930
+يمكنك أن تكون مرحب، لا أحد يمكنه أن يطلب منك أي
+
+227
+00:15:19,930 --> 00:15:25,420
+شيء، هذا يعني إيقاف، إيقافthat we have the first
+
+228
+00:15:25,420 --> 00:15:27,680
+time and the second and the first time you can be
+
+229
+00:15:27,680 --> 00:15:30,220
+free no one can ask you for some people
+
+230
+00:15:30,220 --> 00:15:35,380
+liquidation is a solution it's good for some
+
+231
+00:15:35,380 --> 00:15:38,400
+people it's not it's bad thing because liquidation
+
+232
+00:15:38,400 --> 00:15:43,480
+it means an execution اعدام execution for the
+
+233
+00:15:43,480 --> 00:15:48,410
+person whether going to be a natural person orفتشة
+
+234
+00:15:48,410 --> 00:15:51,530
+person company or human being it's execution
+
+235
+00:15:51,530 --> 00:15:55,690
+because this is the end of the life that's it done
+
+236
+00:15:55,690 --> 00:15:58,950
+close the business take your money you will be
+
+237
+00:15:58,950 --> 00:16:02,010
+frozen stopped you cannot work anymore in the
+
+238
+00:16:02,010 --> 00:16:06,190
+market even if you have a discharge VFA and you
+
+239
+00:16:06,190 --> 00:16:10,070
+haveفي المستقبل إذا كنت ترغب في العودة لشركة لأنك
+
+240
+00:16:10,070 --> 00:16:12,650
+قد تعود لشركة في المستقبل إذا كنت ترغب في العودة
+
+241
+00:16:12,650 --> 00:16:14,990
+لشركة في المستقبل في المستقبل في المستقبل في
+
+242
+00:16:14,990 --> 00:16:17,730
+المستقبل في المستقبل في المستقبل في المستقبل في
+
+243
+00:16:17,730 --> 00:16:17,790
+المستقبل في المستقبل في المستقبل في المستقبل في
+
+244
+00:16:17,790 --> 00:16:18,330
+المستقبل في المستقبل في المستقبل في المستقبل في
+
+245
+00:16:18,330 --> 00:16:18,730
+المستقبل في المستقبل في المستقبل في المستقبل في
+
+246
+00:16:18,730 --> 00:16:22,310
+المستقبل في المستقبل في المستقبل في المستقبل في
+
+247
+00:16:22,310 --> 00:16:26,790
+المستقبل في المستقبل في المستقبل في المستقبل في
+
+248
+00:16:26,790 --> 00:16:28,870
+المستقبل في المستقبل في المستقبل في المستقبل في
+
+249
+00:16:28,870 --> 00:16:34,620
+المستقبل في المستقبل في المستقبلI did not be .. I
+
+250
+00:16:34,620 --> 00:16:37,600
+was free .. by the way in Islam there is no
+
+251
+00:16:37,600 --> 00:16:41,100
+bankruptcy .. no bankruptcy .. because in Islam if
+
+252
+00:16:41,100 --> 00:16:43,500
+you are in debt you have to be in the debts ..
+
+253
+00:16:43,500 --> 00:16:46,480
+even once .. even after you pass away .. after you
+
+254
+00:16:46,480 --> 00:16:50,110
+die .. your inheritance will have to be thereبسبب
+
+255
+00:16:50,110 --> 00:16:54,450
+أن كل شيء سيكون مغفر باستثناء المقابلين، ولكن هذا
+
+256
+00:16:54,450 --> 00:16:58,430
+قانون مجنون، حتى في بلستان اليوم، لدينا نفس الوضع،
+
+257
+00:16:58,430 --> 00:17:01,750
+قانون مجنون، لدينا مغامرة، و لدينا بعض الحالات في
+
+258
+00:17:01,750 --> 00:17:04,510
+غزا هنا، في التي لدينا بعض الناس اللي طلبوا
+
+259
+00:17:04,510 --> 00:17:07,670
+المغامرة، لأنها كانت الوحيدة الموجودة لهم، لا
+
+260
+00:17:07,670 --> 00:17:10,570
+يمكنوا أن يدفعوا المقابلين، ولكن إذا أردوا في
+
+261
+00:17:10,570 --> 00:17:13,650
+المستقبل أن يدفعوا المقابلين، حتى لو كانوا لديهم
+
+262
+00:17:13,650 --> 00:17:16,230
+حرية، فهي مقبلة لهم، ولكن لا أحد يستطيع أن يضطر
+
+263
+00:17:17,340 --> 00:17:23,140
+الدتر اللي يصبح مغامر، الدتر يصبح مغامر، لا أحد
+
+264
+00:17:23,140 --> 00:17:27,860
+يستطيع أن يجعله يكون أي شيء، خارج، خارج، ولا حد
+
+265
+00:17:27,860 --> 00:17:33,740
+بيساعده، هذا حياة جديدة، تخيل، هذا ليس شيء مقبول
+
+266
+00:17:33,740 --> 00:17:37,400
+في مجتمعنا، أليس كذلك؟ ماذا يمكنك أن تفعل؟ مثلًا،
+
+267
+00:17:37,400 --> 00:17:42,220
+إذا أعطيت شخص 10 ألف دينا أو 20 ألف دينا،
+
+268
+00:17:46,300 --> 00:17:51,040
+you might take drastic actions in society here
+
+269
+00:17:51,040 --> 00:17:54,360
+which people don't believe in bankruptcy because
+
+270
+00:17:54,360 --> 00:17:57,400
+they spend their life making money and suddenly
+
+271
+00:17:57,400 --> 00:17:59,740
+somebody take your money and get away with that
+
+272
+00:17:59,740 --> 00:18:05,020
+but this system of bankruptcy is made for honest
+
+273
+00:18:05,020 --> 00:18:10,660
+honest you might lose you might win say well
+
+274
+00:18:10,660 --> 00:18:14,160
+somebody isn't dead and he or she has no money
+
+275
+00:18:14,160 --> 00:18:18,790
+what can we doهل سيبقى في الحياة بقية حياته في
+
+276
+00:18:18,790 --> 00:18:23,970
+الحجر؟ هذا لن يخلق اي اختلاف لك و لا يخلق اي
+
+277
+00:18:23,970 --> 00:18:27,270
+اختلاف لأحد اذا كان في الحجر او في المنزل او
+
+278
+00:18:27,270 --> 00:18:31,530
+بمفرده لن يبقى .. لن يبقى على أي حال لأنه لن يحصل
+
+279
+00:18:31,530 --> 00:18:34,350
+على المال لكن اذا كان او انها بمفرده يمكن أن
+
+280
+00:18:34,350 --> 00:18:37,910
+يعملوا و يكونوا مجانين في المستقبل بس احنا عايزين
+
+281
+00:18:37,910 --> 00:18:42,930
+نبسوا يعنى؟ لا بس بانكرابسي اذا اناس بانكرابسي
+
+282
+00:18:42,930 --> 00:18:45,850
+خلاص you can't ask you can't ask nothing
+
+283
+00:18:55,330 --> 00:18:59,050
+التعذيب هو توقف عن العمل في مجتمعك ستشاهد ..
+
+284
+00:18:59,050 --> 00:19:03,250
+ستشاهد لاحقًا أننا لدينا بعض المفاجأة أو الانفجار،
+
+285
+00:19:03,250 --> 00:19:06,570
+ماذا سيحدث لهذا الشخص؟ نحن لدينا الكثير من النقطة،
+
+286
+00:19:06,570 --> 00:19:10,190
+ماذا سيحدث لك بشكل عام في المجتمع إذا أصبحت
+
+287
+00:19:10,190 --> 00:19:14,870
+انفجار؟ إنه ليس بسهولة، إنه مضغوط، مثل وصمة، ضد
+
+288
+00:19:14,870 --> 00:19:19,350
+ذلك الشخص، شخص .. أحيانًا الناس مثل هذا لا يخرج
+
+289
+00:19:19,350 --> 00:19:23,230
+حتى في الشوارع لتتحدث مع الناس لأنهم يشعرون بالخوف
+
+290
+00:19:24,440 --> 00:19:27,460
+They lost their dignity، they lost their honesty،
+
+291
+00:19:27,460 --> 00:19:31,380
+they can't talk to people anymore. There is
+
+292
+00:19:31,380 --> 00:19:33,280
+something I want to mention before talking about
+
+293
+00:19:33,280 --> 00:19:36,660
+bankruptcy in the states. We have something called
+
+294
+00:19:36,660 --> 00:19:41,180
+bankruptcy fraud. We have a number of people who
+
+295
+00:19:41,180 --> 00:19:44,120
+are applying for bankruptcy. In fact, they are not
+
+296
+00:19:44,120 --> 00:19:48,210
+bankrupted.في الحقيقة هم ليسوا مغامرين، إذا كنت
+
+297
+00:19:48,210 --> 00:19:53,550
+تبحث في جوجل، إذا كنت تفتح جوجل و تبحث، ستجد ألف
+
+298
+00:19:53,550 --> 00:19:58,630
+شركة مغامرة كل عام، ألف، في أوروبا، حتى ألف ألف
+
+299
+00:19:58,630 --> 00:20:02,370
+شركات، ستجد الكثير من الشخصيات، أنا أعرف، لقد رأيت
+
+300
+00:20:02,370 --> 00:20:04,110
+الكثير من الأمثلة مثل هذه عندما كنت في الولايات
+
+301
+00:20:04,110 --> 00:20:07,410
+المتحدة، الناس اللي طلبوا المغامرة، على الرغم من
+
+302
+00:20:07,410 --> 00:20:10,450
+الحقيقة أن بعضهم كانوا مخاطرين، مخاطرين، يمكنهم أن
+
+303
+00:20:10,450 --> 00:20:15,200
+يختبئوا المال في مكان ما، ويقولون، نحن فاترينالأن،
+
+304
+00:20:15,200 --> 00:20:19,160
+كيف نتعامل مع حالة مثل هذه؟ إذا لم يكن هناك تجارب،
+
+305
+00:20:19,160 --> 00:20:24,720
+إذا قمنا بتأكيد أن هذه الشخصة كانت تخاطب الحكومة و
+
+306
+00:20:24,720 --> 00:20:29,100
+كان لديه المال و كان يخلقه و لم يتبع نظام القانون،
+
+307
+00:20:29,100 --> 00:20:33,680
+فلن يكون هناك تجارب، لن يكون مغفر، لن يكون غير
+
+308
+00:20:33,680 --> 00:20:38,540
+مسؤول، فعلينا أن نتبعه حتى نحصل على المال، لكن
+
+309
+00:20:38,540 --> 00:20:41,390
+المشكلة هي أنها ليست أسهل لكي نثبت عليهابسبب أن
+
+310
+00:20:41,390 --> 00:20:44,790
+بعض الناس الصحيحة .. بعض الناس الصحيحة يستطيعون أن
+
+311
+00:20:44,790 --> 00:20:47,870
+يخرجوا من المال .. يعرفون أن بعض الناس تعمل الشركة
+
+312
+00:20:47,870 --> 00:20:50,910
+.. تفتح الشركات .. يحصلوا على بعض الدفعات من
+
+313
+00:20:50,910 --> 00:20:55,270
+الشركات .. ملايين أو باون .. ملايين .. و يتوقفوا
+
+314
+00:20:55,270 --> 00:20:57,490
+.. يفتحوا الشركة لأحد أو اثنين سنة .. و بعد ذلك
+
+315
+00:20:57,490 --> 00:21:01,590
+يقوموا بالتخلص .. مثل ذلك .. يختبئوا المال مع شخص
+
+316
+00:21:01,590 --> 00:21:05,910
+آخر .. و ليس لديهم أي شيء في إسمهم .. لا شيء .. و
+
+317
+00:21:05,910 --> 00:21:06,830
+يحاولون أن يفقدوا ..
+
+318
+00:21:10,750 --> 00:21:15,550
+then بستفيدوا or they get the money or they don't
+
+319
+00:21:15,550 --> 00:21:20,790
+care about it they don't care about reputation so
+
+320
+00:21:20,790 --> 00:21:23,670
+those are type of people we have them we have such
+
+321
+00:21:23,670 --> 00:21:28,550
+people such people but if we can prove that this
+
+322
+00:21:28,550 --> 00:21:31,910
+person was not honest the bankrupt was not honest
+
+323
+00:21:31,910 --> 00:21:35,990
+then he will not get it will not be forgiven he
+
+324
+00:21:35,990 --> 00:21:39,340
+will not be this situation he can he should beالان
+
+325
+00:21:39,340 --> 00:21:41,620
+يجب أن نتحرك إلى الانفجار في الولايات المتحدة،
+
+326
+00:21:41,620 --> 00:21:45,620
+ببعض الصفحات الولايات
+
+327
+00:21:45,620 --> 00:21:50,960
+المتحدة مثل بلد أخرى، لديها قانونها الخاصة، وهو
+
+328
+00:21:50,960 --> 00:21:54,060
+اسمها الانفجار، انت تعرفين أننا في الولايات لدينا،
+
+329
+00:21:54,060 --> 00:22:02,300
+لدينا خمسين او اتس، كل شرطة، كل شرطة لها قانونها
+
+330
+00:22:02,300 --> 00:22:10,190
+الخاصة، كل شرطة لها قانونها الخاصةصانعي القانون
+
+331
+00:22:10,190 --> 00:22:14,230
+but sometimes we have some important issues in
+
+332
+00:22:14,230 --> 00:22:17,710
+which we have to deal with them by the congress
+
+333
+00:22:17,710 --> 00:22:24,250
+here on the federal jurisdictions the most
+
+334
+00:22:24,250 --> 00:22:26,990
+important issues at all which concerning the whole
+
+335
+00:22:26,990 --> 00:22:32,640
+united states can beيمكن أن يتم إدارته من الكونغرس
+
+336
+00:22:32,640 --> 00:22:37,480
+على مستوى فدرال، مستوى فدرال، نظام فدرالي، وهو
+
+337
+00:22:37,480 --> 00:22:40,700
+مستوى الولايات المتحدة عامة، واحدة منها هي
+
+338
+00:22:40,700 --> 00:22:44,620
+الانفجار، الانفجار في الولايات المتحدة هي موقع
+
+339
+00:22:44,620 --> 00:22:49,220
+كبير تحت مستوى فدرال، فهو فقط واحد قانون لكل
+
+340
+00:22:49,220 --> 00:22:52,380
+مستوى، ليس كل مستوى، مثلا إذا أردنا لدينا قانون
+
+341
+00:22:52,380 --> 00:22:58,270
+عالمي، قانون مجتمعيتاكس، يمكنك أن تكون هناك أشياء
+
+342
+00:22:58,270 --> 00:23:02,230
+تتميزها في كل شرطة، ولكن عندما يتعلق بالانفجار،
+
+343
+00:23:02,230 --> 00:23:04,610
+حتى إذا كانت جزء من القواعد التجارية، لكن الانفجار
+
+344
+00:23:04,610 --> 00:23:08,050
+يتم تنظيمه تحت مجموعة فدرالية، مجموعة فدرالية،
+
+345
+00:23:08,050 --> 00:23:08,930
+مجموعة فدرالية، مجموعة فدرالية، مجموعة فدرالية،
+
+346
+00:23:08,930 --> 00:23:10,150
+مجموعة فدرالية، مجموعة فدرالية، مجموعة فدرالية،
+
+347
+00:23:10,150 --> 00:23:12,590
+مجموعة فدرالية، مجموعة فدرالية، مجموعة فدرالية،
+
+348
+00:23:12,590 --> 00:23:15,970
+مجموعة
+
+349
+00:23:15,970 --> 00:23:20,730
+فدرالية، مجموعة
+
+350
+00:23:20,730 --> 00:23:27,570
+فدرالية، مجموعةهذا الموضوع يؤثر على نوع ال .. نوع
+
+351
+00:23:27,570 --> 00:23:29,290
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+352
+00:23:29,290 --> 00:23:29,730
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+353
+00:23:29,730 --> 00:23:30,310
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+354
+00:23:30,310 --> 00:23:34,170
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+355
+00:23:34,170 --> 00:23:35,510
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+356
+00:23:35,510 --> 00:23:35,530
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+357
+00:23:35,530 --> 00:23:36,110
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+358
+00:23:36,110 --> 00:23:38,190
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+359
+00:23:38,190 --> 00:23:41,650
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+360
+00:23:41,650 --> 00:23:46,210
+ال .. نوع ال .. نوع ال .. نوع ال .. نوع ال .. نوع
+
+361
+00:23:46,210 --> 00:23:52,670
+ال .. نوع ال .. نوع
+
+362
+00:23:56,560 --> 00:23:59,100
+Bankruptcy is something affect the whole society.
+
+363
+00:24:00,360 --> 00:24:02,080
+We are not talking about small companies. We are
+
+364
+00:24:02,080 --> 00:24:05,360
+talking about big companies, corporations. Some of
+
+365
+00:24:05,360 --> 00:24:09,680
+them invest billions, billions of dollars. Some of
+
+366
+00:24:09,680 --> 00:24:14,700
+them, some of those companies employ tens of
+
+367
+00:24:14,700 --> 00:24:16,780
+thousands of people. Imagine one company having
+
+368
+00:24:16,780 --> 00:24:20,640
+300,000 employees. What would happen to this
+
+369
+00:24:20,640 --> 00:24:23,920
+company if it's bankrupted? What would happen to
+
+370
+00:24:23,920 --> 00:24:28,240
+the state economy?شركة واحدة تكون لديها 50 ألف
+
+371
+00:24:28,240 --> 00:24:33,000
+موظف، 50، تخيل أن 50 ألف موظف اليوم يجلسون في
+
+372
+00:24:33,000 --> 00:24:35,800
+المنزل، ليس لديهم إيجار، ماذا سيحدث؟ في إحدى أو
+
+373
+00:24:35,800 --> 00:24:38,680
+إتين إمارات؟ هذا سيؤثر على إقتصاد الولايات
+
+374
+00:24:38,680 --> 00:24:41,880
+المتحدة، ثم يجب أن يكون الحكومة الولايات المتحدة
+
+375
+00:24:41,880 --> 00:24:45,660
+تدفع تلك الناس لإنقاذهم، يجب أن تدفع تدفع تدفع
+
+376
+00:24:45,660 --> 00:24:47,200
+تدفع تدفع تدفع تدفع تدفع تدفع تدفع تدفع تدفع تدفع
+
+377
+00:24:47,200 --> 00:24:50,880
+تدفع تدفع تدفع تدفع تدفع تدفع تدفع تدفع تدفع ت
+
+378
+00:24:51,430 --> 00:24:55,330
+هو مصطلح مصطلح مصطلح الولايات. واحد من الأشياء
+
+379
+00:24:55,330 --> 00:24:57,110
+الرئيسية في النظام الاقتصادي في الولايات هي
+
+380
+00:24:57,110 --> 00:25:01,030
+القانون التجاربي. القانون التجاربي يجب أن يكون
+
+381
+00:25:01,030 --> 00:25:05,570
+مصطلح في أعلى مستوى في الواقع يجب أن نحمي المجتمع.
+
+382
+00:25:06,170 --> 00:25:09,950
+لا نريد اي شركة فقط في أي وقت، يا عزيزي، نطلب فقط
+
+383
+00:25:09,950 --> 00:25:14,190
+تجارب. لا، عليك أن تكون مسؤول عن هذا. نحن نعمل هنا
+
+384
+00:25:14,190 --> 00:25:19,110
+قرارات صعبةونجعل الاختصارات مرتبطة باختصارات
+
+385
+00:25:19,110 --> 00:25:19,170
+مرتبطة باختصارات مرتبطة باختصارات مرتبطة باختصارات
+
+386
+00:25:19,170 --> 00:25:22,810
+مرتبطة باختصارات مرتبطة باختصارات مرتبطة باختصارات
+
+387
+00:25:22,810 --> 00:25:25,790
+مرتبطة باختصارات مرتبطة باختصارات مرتبطة باختصارات
+
+388
+00:25:25,790 --> 00:25:26,350
+مرتبطة باختصارات مرتبطة باختصارات مرتبطة باختصارات
+
+389
+00:25:26,350 --> 00:25:26,610
+مرتبطة باختصارات مرتبطة باختصارات مرتبطة باختصارات
+
+390
+00:25:26,610 --> 00:25:45,190
+مرتبطة باختصارات مرتبطة باختصارات مرتبطة باختصارات
+
+391
+00:25:45,190 --> 00:25:54,190
+مرتبطةانت تحتاج اكتشاف اكتشاف انت
+
+392
+00:25:54,190 --> 00:26:03,470
+تحتاج اكتشاف انت تحتاج اكتشاف انت
+
+393
+00:26:03,470 --> 00:26:04,310
+تحتاج اكتشاف انت تحتاج اكتشاف انت تحتاج اكتشاف انت
+
+394
+00:26:04,310 --> 00:26:04,730
+تحتاج اكتشاف انت تحتاج اكتشاف انت تحتاج اكتشاف انت
+
+395
+00:26:04,730 --> 00:26:05,310
+تحتاج اكتشاف انت تحتاج اكتشاف انت تحتاج اكتشاف انت
+
+396
+00:26:05,310 --> 00:26:05,530
+تحتاج اكتشاف انت تحتاج اكتشاف انت تحتاج اكتشاف انت
+
+397
+00:26:05,530 --> 00:26:07,490
+تحتاج اكتشاف انت تحتاج اكتشاف انت تحتاج اكتشاف انت
+
+398
+00:26:07,490 --> 00:26:16,090
+تحتاج اكتشاف انت تحتاج اكتشاف انت تحتاج اكتشاف انت
+
+399
+00:26:16,090 --> 00:26:18,360
+تحتاج اكتشالنسبة للانفجار في جميع الولايات
+
+400
+00:26:18,360 --> 00:26:22,220
+المتحدة، في جميع الولايات المتحدة، لكن، حسنا، يجب
+
+401
+00:26:22,220 --> 00:26:24,860
+أن نطلق القانون الانفجاري، اللي مجرد مجتمع
+
+402
+00:26:24,860 --> 00:26:28,960
+الانفجار، ولكن يجب أن نطلقه في كل شرطة، أليس كذلك؟
+
+403
+00:26:28,960 --> 00:26:33,140
+هل تعتقد أن في كل شرطة لديها نفس الوضع؟ ليس كذلك،
+
+404
+00:26:33,140 --> 00:26:36,820
+كل شرطة لديها قانون مخصص، قانون مخصص، قانون مخصص،
+
+405
+00:26:36,820 --> 00:26:38,260
+قانون مخصص، قانون مخصص، قانون مخصص، قانون مخصص،
+
+406
+00:26:38,260 --> 00:26:43,720
+قانون مخصص، قانون مخصص، قانون مخصص، قانون مخصص،ثم
+
+407
+00:26:43,720 --> 00:26:49,580
+نأخذ قانون الانفجار في كل مصطلح، في كل مصطلح،
+
+408
+00:26:49,580 --> 00:26:54,360
+نستطيع تأكيده، ليس تأكيده كتغيير، بل نستطيع تأكيده
+
+409
+00:26:54,360 --> 00:26:59,140
+لكي يكون مناسب لكل مصطلح، لكن في نفس الوقت، ليس
+
+410
+00:26:59,140 --> 00:27:05,300
+ليه يؤثر على قانون الانفجار، هي مثل تأكيدها، لكن
+
+411
+00:27:05,300 --> 00:27:07,700
+تأكيدها، هل أحد يقدر يقرأها؟
+
+412
+00:27:16,560 --> 00:27:20,760
+القانون القانون مقاومة بشكل عام بشكل عام بشكل عام
+
+413
+00:27:20,760 --> 00:27:22,200
+بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل
+
+414
+00:27:22,200 --> 00:27:24,540
+عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام
+
+415
+00:27:24,540 --> 00:27:26,140
+بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل
+
+416
+00:27:26,140 --> 00:27:26,160
+عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام
+
+417
+00:27:26,160 --> 00:27:26,160
+بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل
+
+418
+00:27:26,160 --> 00:27:26,300
+عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام
+
+419
+00:27:26,300 --> 00:27:31,200
+بشكل عام بشكل عام بشكل عام بشكل
+
+420
+00:27:31,200 --> 00:27:39,380
+عام بشكل عام بشكل عام بش
+
+421
+00:27:42,300 --> 00:27:45,480
+بالنسبة ليس مع تغيير القواعد ولكن لدينا بعض
+
+422
+00:27:45,480 --> 00:27:48,300
+الاعتبارات التي يمكننا استخدام القواعد الانفجارية
+
+423
+00:27:48,300 --> 00:27:52,060
+ولكن يمكننا استخدام احتاجاتنا احتاجاتنا في كل
+
+424
+00:27:52,060 --> 00:27:55,160
+مجتمع وفي كل مدينة لأن إذا تنظر إلى الشمال والشرق
+
+425
+00:27:55,160 --> 00:27:58,480
+في المدينة ليسوا على نفس المستوى في الشمال هم
+
+426
+00:27:58,480 --> 00:28:02,200
+عارفين وفي الشرق هم فارغين في بعض المدن تكون لديك
+
+427
+00:28:02,200 --> 00:28:04,580
+الكثير من التجارب لكي تكون مدفن في أخر مدن لم تكن
+
+428
+00:28:04,580 --> 00:28:07,200
+لديك كثير من التجارب لأنك تريد أن تجعل الناس
+
+429
+00:28:07,200 --> 00:28:09,240
+يستخدمون المال
+
+430
+00:28:12,260 --> 00:28:17,680
+الان في الولايات لدينا بنكروبسي بنكروبسي الواقع
+
+431
+00:28:17,680 --> 00:28:22,540
+يتم تحويله إلى اتصال اتصال اتصال اتصال اتصال اتصال
+
+432
+00:28:22,540 --> 00:28:26,380
+اتصال اتصال اتصال اتصال اتصال اتصال
+
+433
+00:28:26,380 --> 00:28:26,380
+اتصال اتصال اتصال اتصال اتصال اتصال اتصال اتصال
+
+434
+00:28:26,380 --> 00:28:26,560
+اتصال اتصال اتصال اتصال اتصال اتصال اتصال اتصال
+
+435
+00:28:26,560 --> 00:28:26,940
+اتصال اتصال اتصال اتصال اتصال اتصال اتصال اتصال
+
+436
+00:28:26,940 --> 00:28:27,040
+اتصال اتصال اتصال اتصال اتصال اتصال اتصال اتصال
+
+437
+00:28:27,040 --> 00:28:27,900
+اتصال اتصال اتصال
+
+438
+00:28:46,590 --> 00:28:52,830
+او ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او
+
+439
+00:28:52,830 --> 00:28:52,990
+ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او
+
+440
+00:28:52,990 --> 00:28:52,990
+ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او
+
+441
+00:28:52,990 --> 00:28:52,990
+ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او
+
+442
+00:28:52,990 --> 00:28:54,370
+ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او
+
+443
+00:28:54,370 --> 00:29:06,290
+ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او ايه؟ او
+
+444
+00:29:06,290 --> 00:29:12,250
+ايه؟ اوas a debtor why should we sell and we
+
+445
+00:29:12,250 --> 00:29:14,950
+divide because in return you have to have the
+
+446
+00:29:14,950 --> 00:29:19,170
+freedom this charge in exchange the debtor is
+
+447
+00:29:19,170 --> 00:29:25,750
+entitled to a discharge بمعنى الاعفاء that's it
+
+448
+00:29:25,750 --> 00:29:29,250
+اعفاء the freedom we have we have the freedom we
+
+449
+00:29:29,250 --> 00:29:31,490
+have the discharge for that person what do you
+
+450
+00:29:31,490 --> 00:29:33,310
+think there's something here we have to keep in
+
+451
+00:29:33,310 --> 00:29:35,230
+our minds someone
+
+452
+00:29:37,040 --> 00:29:42,620
+الشخص كان عالق و أخذنا كل ما كان لديه و أخذنا بعض
+
+453
+00:29:42,620 --> 00:29:50,100
+المال و قليل من المال منه و عائلته لننجو و أخذنا
+
+454
+00:29:50,100 --> 00:29:57,080
+المال
+
+455
+00:29:57,080 --> 00:30:02,820
+و أخذنا المال و أخذنا
+
+456
+00:30:02,820 --> 00:30:02,880
+المال و أخذنا المال و أخذنا المال و أخذنا المال و
+
+457
+00:30:02,880 --> 00:30:02,920
+أخذنا المال و أخذنا المال و أخذنا المال و أخذنا
+
+458
+00:30:02,920 --> 00:30:02,920
+المال و أخذنا المال و أخذنا المال و أخذنا المال و
+
+459
+00:30:02,920 --> 00:30:02,920
+أخذنا المال و أخذنا المال و أخذنا المال و أخذنا
+
+460
+00:30:02,920 --> 00:30:02,920
+المال و أخذنا المال و أخذنا المال و أخذنا المال و
+
+461
+00:30:02,920 --> 00:30:02,920
+أخذنا المال و أخذنا المال و أخذنا المال و أخذنا
+
+462
+00:30:02,920 --> 00:30:05,380
+المال و أخذنا المال و أالإنسان هو الكنيسة والحرية
+
+463
+00:30:05,380 --> 00:30:09,900
+ولكن نحن لدينا بعض الاعتبارات، اسمع هذا بطيئة، نحن
+
+464
+00:30:09,900 --> 00:30:15,700
+لدينا بعض الاعتبارات، نحن نغفر الناس مثل دوس، نحن
+
+465
+00:30:15,700 --> 00:30:18,680
+لن نطلب منهم في المستقبل لأي شيء، ولكن نفعل ذلك
+
+466
+00:30:18,680 --> 00:30:22,530
+أحياناWe do have some exceptions in which you
+
+467
+00:30:22,530 --> 00:30:25,590
+would have to pay the money even if it takes 50
+
+468
+00:30:25,590 --> 00:30:28,630
+years, even if it takes the end of your life as a
+
+469
+00:30:28,630 --> 00:30:30,990
+debtor, you would have to pay the money. We have
+
+470
+00:30:30,990 --> 00:30:34,130
+two examples like for example here, a discharge
+
+471
+00:30:34,130 --> 00:30:37,910
+will not be applicable in those two cases. Can you
+
+472
+00:30:37,910 --> 00:30:38,170
+read it?
+
+473
+00:30:44,690 --> 00:30:56,510
+مضنب يعني مضنب مضنب
+
+474
+00:30:56,510 --> 00:31:03,020
+مضنب مضنب مضنبفي حالة اقتصادية هنا حتى في حالة
+
+475
+00:31:03,020 --> 00:31:07,100
+اقتصادية مرتبطة بشكل أكتر لأن إذا قمت بإخفاء شيء
+
+476
+00:31:07,100 --> 00:31:10,760
+إذا قمت بإخفاء المال إذا قمت بإخفاء حسابات الحكومة
+
+477
+00:31:10,760 --> 00:31:17,340
+إذا قمت بإبقاء حساباتك بعيدا من المؤمنين في جميع
+
+478
+00:31:17,340 --> 00:31:21,760
+الحالات هنا لن تكون في هذه الحالة علينا أن نتبع
+
+479
+00:31:21,760 --> 00:31:26,000
+ذلك الشخص مرة أخرى و مرة أخرى حتى يدفع رقم 2
+
+480
+00:31:35,840 --> 00:31:39,180
+even if you are discharged there are some debts
+
+481
+00:31:39,180 --> 00:31:42,840
+you will not be like some of them some of those
+
+482
+00:31:42,840 --> 00:31:45,100
+are connected with the public policy public
+
+483
+00:31:45,100 --> 00:31:49,960
+interest like the tax tax tax is not personal debt
+
+484
+00:31:49,960 --> 00:31:53,780
+isn't it it's not personal tax is for the state
+
+485
+00:31:54,790 --> 00:31:56,790
+then you have to pay it for the government, it's
+
+486
+00:31:56,790 --> 00:32:01,270
+not for personal debt. In addition to spousal
+
+487
+00:32:01,270 --> 00:32:06,170
+support, spousal like the wife, his wife and he's
+
+488
+00:32:06,170 --> 00:32:09,070
+supposed to be because how can she live, how can
+
+489
+00:32:09,070 --> 00:32:11,690
+she survive, his children, that's what we call
+
+490
+00:32:11,690 --> 00:32:15,870
+spousal supportالمال يجب أن يكون مدفع لأننا نتكلم
+
+491
+00:32:15,870 --> 00:32:20,270
+هنا عن الحياة، المشكلة بالحياة، الانتصار الواضح في
+
+492
+00:32:20,270 --> 00:32:24,330
+تلك الحالات، هؤلاء هم إمثالين، أعني، يمكن الحرس أن
+
+493
+00:32:24,330 --> 00:32:28,770
+يجد طريقات لإيقاف حالة فيها في بعض الأحيان، في بعض
+
+494
+00:32:28,770 --> 00:32:33,990
+الأحيان، لن نكون قادرين على إخلاء الـBankrupt في
+
+495
+00:32:33,990 --> 00:32:38,050
+بعض الحالات هل يكون هناك تجارب مثل التجارب
+
+496
+00:32:38,050 --> 00:32:43,760
+والتجارب لأنها تم تجاربها؟بقى دي mean بقى دي
+
+497
+00:32:43,760 --> 00:32:47,340
+مابتاخد انه مابتنعرفها ان قولت انه some taxes
+
+498
+00:32:47,340 --> 00:32:52,060
+doesn't have this charge about it because it's
+
+499
+00:32:52,060 --> 00:32:57,300
+before it's exempted صح؟ it's not exempted the tax
+
+500
+00:32:57,300 --> 00:33:01,180
+it's not؟ في عنها exemptions و deductionsفي
+
+501
+00:33:01,180 --> 00:33:03,720
+reduction sometimes it's not .. I mean the tax it
+
+502
+00:33:03,720 --> 00:33:08,340
+was .. it was not personal right it was the state
+
+503
+00:33:08,340 --> 00:33:10,460
+it was for the state and it's supposed to be for
+
+504
+00:33:10,460 --> 00:33:15,980
+the state and even .. the tax .. we pay the tax
+
+505
+00:33:15,980 --> 00:33:19,040
+for the state or not .. tax office .. we pay the
+
+506
+00:33:19,040 --> 00:33:22,200
+tax for the tax office and like people who did not
+
+507
+00:33:22,200 --> 00:33:25,000
+pay the tax for a while of time and then we
+
+508
+00:33:25,000 --> 00:33:27,260
+discover this they have to pay it .. they will
+
+509
+00:33:27,260 --> 00:33:27,900
+have to pay it
+
+510
+00:33:31,360 --> 00:33:36,040
+شخص ما أسألني قبل وقت ما اتسأل اذا الانتجار ليس
+
+511
+00:33:36,040 --> 00:33:39,440
+لديه أي شيء على الإطلاق، ماذا نفعل؟ ليس لديه أي
+
+512
+00:33:39,440 --> 00:33:46,300
+شيء، انتجار ليس لديه أي شيء، ماذا نفعل؟ انتجار ليس
+
+513
+00:33:46,300 --> 00:33:53,380
+لديه أي شيء، ماذا نفعل؟ انتجار ليس لديه أي شيء،
+
+514
+00:33:53,380 --> 00:33:57,680
+ماذا نفعل؟ انتجار ليس لديه أي شيء، ماذا نفعل؟ ماذا
+
+515
+00:33:57,680 --> 00:33:57,780
+نفعل؟ ماذا نفعل؟ ماذا نفعل؟ ماذا نفعل؟ ماذا نفعل؟
+
+516
+00:33:57,780 --> 00:33:57,840
+ماذا نفعل؟ ماذا نفعل؟ ماذا نفعل؟ ماذا نفعل؟ ماذا
+
+517
+00:33:57,840 --> 00:34:00,940
+نفعل؟ ماذا نفعل؟ ماذا نفعل؟ ماذا نالسيارات
+
+518
+00:34:00,940 --> 00:34:05,700
+القديمة، أشياء مثل هذه مخرجة هل سنأخذه منه أو
+
+519
+00:34:05,700 --> 00:34:15,100
+سنبقى بيهم؟ البرج يعطي هذا الشخص شيء يجعله يبقى
+
+520
+00:34:15,100 --> 00:34:17,140
+حياة في هذا البرج ليس مثلًا إنه ليس لديه أي شيء
+
+521
+00:34:17,140 --> 00:34:21,780
+إلا إذا كان مخرج من البرج لا يمكننا أن نأخذه
+
+522
+00:34:21,780 --> 00:34:34,880
+بالطبع هل أنت متأكدة؟ نعمإذا كانت المالك تتعلق
+
+523
+00:34:34,880 --> 00:34:39,900
+بالمالك، هل ستغفر هذا الشخص؟ لا، لن نتعامل مع
+
+524
+00:34:39,900 --> 00:34:46,320
+بعضنا البعض في الولايات المتحدة، يقول، نحن لدينا
+
+525
+00:34:46,320 --> 00:34:51,700
+شيء يسمى بالإنقاذ، يعني نفس الشيء، إنه تجارب كبير،
+
+526
+00:34:51,700 --> 00:34:55,260
+كم عادة يستطيع شخص ما يستخدمها للإنقاذ؟ كم عادة
+
+527
+00:34:55,260 --> 00:34:58,330
+يستطيع شخص ما يستطيع استخدامها للإنقاذ؟اليوم،
+
+528
+00:34:58,330 --> 00:35:01,390
+اليوم، لدينا مغامرة، هل نستعمل مرة أخرى في
+
+529
+00:35:01,390 --> 00:35:08,450
+المستقبل؟ نعم، في بعض الأيام، نعم، في بعض الأيام،
+
+530
+00:35:08,450 --> 00:35:08,730
+نعم، في بعض الأيام، نعم، نعم، نعم، نعم، نعم، نعم،
+
+531
+00:35:08,730 --> 00:35:08,830
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+532
+00:35:08,830 --> 00:35:08,830
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+533
+00:35:08,830 --> 00:35:08,850
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+534
+00:35:08,850 --> 00:35:11,410
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+535
+00:35:11,410 --> 00:35:14,470
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+536
+00:35:18,950 --> 00:35:22,030
+ثم تتعامل مع نفس الموضوع، هل يمكنك أن تطلع
+
+537
+00:35:22,030 --> 00:35:26,010
+للتجارة؟ نعم، في الولايات المتحدة، يقول إنه يمكنك
+
+538
+00:35:26,010 --> 00:35:31,570
+أن تطلع للتجارة كل 8 سنة، على الأقل، على الأقل،
+
+539
+00:35:31,570 --> 00:35:35,270
+عليك أن تكون بين الأول والثاني التجارة 8 سنة، 8
+
+540
+00:35:35,270 --> 00:35:38,410
+سنة، 8 سنة، 8 سنة، 8 سنة، 8 سنة، 8 سنة، 8 سنة، 8
+
+541
+00:35:38,410 --> 00:35:39,130
+سنة، 8 سنة، 8 سنة، 8 سنة، 8 سنة، 8 سنة، 8 سنة، 8
+
+542
+00:35:39,130 --> 00:35:42,770
+سنة، 8 سنة، 8 سنة، 8 سنة، 8 سنة، 8 سنة، 8 سنة، 8
+
+543
+00:35:42,770 --> 00:35:51,210
+سنة، 8 سنة، 8 سنة، 8 سنة، 8العامين يجب ان ينتظر 8
+
+544
+00:35:51,210 --> 00:35:53,870
+سنة من هناك و من هناك و من هناك و من هناك و من
+
+545
+00:35:53,870 --> 00:35:55,510
+هناك و من هناك و من هناك و من هناك و من هناك و من
+
+546
+00:35:55,510 --> 00:35:57,870
+هناك و من هناك و من هناك و من هناك و من هناك و من
+
+547
+00:35:57,870 --> 00:35:58,550
+هناك و من هناك و من هناك و من هناك و من هناك و من
+
+548
+00:35:58,550 --> 00:35:58,550
+هناك و من هناك و من هناك و من هناك و من هناك و من
+
+549
+00:35:58,550 --> 00:35:58,550
+هناك و من هناك و من هناك و من هناك و من هناك و من
+
+550
+00:35:58,550 --> 00:35:59,190
+هناك و من هناك و من هناك و من هناك و من هناك و من
+
+551
+00:35:59,190 --> 00:35:59,190
+هناك و من هناك و من هناك و من هناك و من هناك و من
+
+552
+00:35:59,190 --> 00:36:00,090
+هناك و من هناك و من هناك و من هناك و من هناك و من
+
+553
+00:36:00,090 --> 00:36:07,950
+هناك و من هناك و من هناك و من هناك و من هناك و من
+
+554
+00:36:07,950 --> 00:36:16,690
+هناك و من هناك و
+
+555
+00:36:16,690 --> 00:36:21,170
+من هناك وو يجب أن يأخذوا المال أولا، حتى لو لم يكن
+
+556
+00:36:21,170 --> 00:36:26,110
+هناك أي شيء موجود خلفه، كل ما لديك حنين، لديك £50
+
+557
+00:36:26,110 --> 00:36:31,870
+,000 و انت مالك و لديك خمس مؤمنين و أنا الوحيد
+
+558
+00:36:31,870 --> 00:36:37,690
+الان مؤمن بأمان و لدي مواصلة و مالي £60,000،
+
+559
+00:36:37,690 --> 00:36:41,400
+أستطيع أن أخذ الـ£50,000and nothing can be left
+
+560
+00:36:41,400 --> 00:36:44,740
+behind for the rest of the creditors because ..
+
+561
+00:36:44,740 --> 00:36:46,780
+because .. because of what? can you read it؟
+
+562
+00:36:46,780 --> 00:36:50,120
+داليا؟ generally the rights of secured creditors
+
+563
+00:36:50,120 --> 00:36:53,940
+to their collateral .. collateral دمانات
+
+564
+00:36:53,940 --> 00:36:58,960
+continuous even though their debt is discharged
+
+565
+00:36:58,960 --> 00:37:03,040
+example .. example absent some arrangement by a
+
+566
+00:37:03,040 --> 00:37:09,180
+debtor to surrender a car or reaffirm a debtالمالك
+
+567
+00:37:09,180 --> 00:37:14,820
+مع مهتمة أمان في سيارة المال يمكن أن يتعامل
+
+568
+00:37:14,820 --> 00:37:19,460
+بالسيارة حتى وإن المال للمالك هو هذه السيارة لدينا
+
+569
+00:37:19,460 --> 00:37:24,060
+مثال هنا في الواضح أن السيارة كانت المواصفة،
+
+570
+00:37:24,060 --> 00:37:27,880
+السيارة نفسها، ربما كانت المنزل، ربما قطعة الأرض،
+
+571
+00:37:27,880 --> 00:37:30,460
+مثلًا أعطيك 20 ألف رمز، ولكن لا أستطيع أن أخذ
+
+572
+00:37:30,460 --> 00:37:34,980
+مواصفة التي هي سيارتك، أبقيها معك، ولكن المواصفة
+
+573
+00:37:34,980 --> 00:37:40,780
+هي السيارة التجاريةإذا أصبحت مالك مغامر و قائدك
+
+574
+00:37:40,780 --> 00:37:44,240
+أخذ سيارتك أستطيع أن أتبعها أستطيع أن أخذها من أي
+
+575
+00:37:44,240 --> 00:37:57,520
+شخص مالك
+
+576
+00:37:57,520 --> 00:37:58,600
+مالك مالك مالك مالك مالك مالك مالك مالك مالك مالك
+
+577
+00:37:58,600 --> 00:37:58,700
+مالك مالك مالك مالك مالك مالك مالك مالك مالك مالك
+
+578
+00:37:58,700 --> 00:37:58,700
+مالك مالك مالك مالك مالك مالك مالك مالك مالك مالك
+
+579
+00:37:58,700 --> 00:37:58,740
+مالك مالك مالك مالك مالك مالك مالك مالك مالك مالك
+
+580
+00:37:58,740 --> 00:37:58,740
+مالك مالك مالك مالك مالك مالك مالك مالك مالك مالك
+
+581
+00:37:58,740 --> 00:37:58,840
+مالك مالك مالك مالك مالك مالك مالك
+
+582
+00:38:07,130 --> 00:38:12,110
+القرن 13 حتى في أضافة لـ Secured Creditors يمكن أن
+
+583
+00:38:12,110 --> 00:38:15,730
+ترى أنهم يمكن أن يكونوا ملازمين لدفعات أكتر من
+
+584
+00:38:15,730 --> 00:38:18,510
+الاستثمار الاستثمار الاستثمار الاستثمار الاستثمار
+
+585
+00:38:18,510 --> 00:38:22,210
+الاستثمار الاستثمار الاستثمار الاستثمار الاستثمار
+
+586
+00:38:22,210 --> 00:38:22,490
+الاستثمار الاستثمار الاستثمار الاستثمار الاستثمار
+
+587
+00:38:22,490 --> 00:38:22,530
+الاستثمار الاستثمار الاستثمار الاستثمار الاستثمار
+
+588
+00:38:22,530 --> 00:38:22,670
+الاستثمار الاستثمار الاستثمار الاستثمار الاستثمار
+
+589
+00:38:22,670 --> 00:38:24,590
+الاستثمار الاستثمار الاستثمار الاستثمار الاستثمار
+
+590
+00:38:24,590 --> 00:38:26,650
+الاستثمار الاستثمار الاستثمار الاستثمار الاستثمار
+
+591
+00:38:26,650 --> 00:38:31,210
+الاستre-organization ليس liquidation، إنها re
+
+592
+00:38:31,210 --> 00:38:35,950
+-organization تتكلم عن محافظة المملكة، موقف جميع
+
+593
+00:38:35,950 --> 00:38:38,870
+الأسات، نفس الشيء، أنا أقصد أنه لا يوجد شيء جديد
+
+594
+00:38:38,870 --> 00:38:43,630
+هنا، إنه يتكلم عن مخطط التعافي والذي ذكرته قبل،
+
+595
+00:38:43,630 --> 00:38:46,510
+يجب أن نكون لدينا مخطط، لا يمكنك التطبيق لتعافي
+
+596
+00:38:46,510 --> 00:38:51,810
+بدون مخطط، وهذا المخطط يجب أن يتم بين اثنين أشخاص،
+
+597
+00:38:51,810 --> 00:38:56,750
+الأول هو المالك، يمكنه أن يجلس مع شخص ما يسمى
+
+598
+00:38:56,750 --> 00:39:01,520
+مصاريفIt can be a lawyer, it can be an accountant,
+
+599
+00:39:02,460 --> 00:39:06,480
+we call him insolvency practitioner, we'll look at
+
+600
+00:39:06,480 --> 00:39:10,620
+them later on Insolvency practitioner, this is a
+
+601
+00:39:10,620 --> 00:39:14,260
+specialist person, can sit down with the debtor,
+
+602
+00:39:14,640 --> 00:39:16,860
+make a calculation, look at the account and the
+
+603
+00:39:16,860 --> 00:39:19,340
+money and what you have in the market and all the
+
+604
+00:39:19,340 --> 00:39:22,760
+assets you have and how much money you can make
+
+605
+00:39:22,760 --> 00:39:25,320
+and how long time it would take
+
+606
+00:39:27,890 --> 00:39:32,990
+وهذا كل شيء سيكون في ملف واحد مع وضعه ووضعه سيكون
+
+607
+00:39:32,990 --> 00:39:35,090
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+608
+00:39:35,090 --> 00:39:35,250
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+609
+00:39:35,250 --> 00:39:36,970
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+610
+00:39:36,970 --> 00:39:39,010
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+611
+00:39:39,010 --> 00:39:39,430
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+612
+00:39:39,430 --> 00:39:40,670
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+613
+00:39:40,670 --> 00:39:45,670
+الوثيقة الوثيقة الوثيقة الو
+
+614
+00:39:46,880 --> 00:39:49,340
+في هذه الحالة .. أعتقد أننا سننظر إلى هذا لاحقًا
+
+615
+00:39:49,340 --> 00:39:53,220
+في يوكيب .. يجب أن يكون لديك تقريبًا تلتين تقريبًا
+
+616
+00:39:53,220 --> 00:39:58,240
+ليس نصف تقريبًا على الأقل يجب أن تكون تقريبًا
+
+617
+00:39:58,240 --> 00:40:00,920
+تلتين تقريبًا لتقريب هذا البرنامج من المستخدمين ..
+
+618
+00:40:00,920 --> 00:40:05,440
+هذا هو الموضوع المهم .. أنا أعمل برنامج .. يجب أن
+
+619
+00:40:05,440 --> 00:40:08,640
+أثبت المستخدمين أني سأجيب عليهم .. إذا لم يقبلوا
+
+620
+00:40:08,640 --> 00:40:10,960
+.. إذا لم يقبلوا ..
+
+621
+00:40:12,770 --> 00:40:17,190
+ولكن إذا اقبلت 2 ثورة منهم بهذه القرارات، فهذه
+
+622
+00:40:17,190 --> 00:40:23,770
+القرارات ستتمتع بالحكومة لإختيارها، حتى لو لم تحصل
+
+623
+00:40:23,770 --> 00:40:28,750
+على المقابلين كلهم، فهذا بخير، يجب أن يكون المجتمع
+
+624
+00:40:28,750 --> 00:40:35,950
+يقبل هذه القرارات، ولكن المجتمع، 1 ثورة منهم، لا
+
+625
+00:40:35,950 --> 00:40:41,050
+نهتم بهم بعدنحن نلقي نظرة على أكتر من المستخدمين
+
+626
+00:40:41,050 --> 00:40:45,250
+الذين يمتلكون أكتر من المال، نلقي نظرة على هذا و
+
+627
+00:40:45,250 --> 00:40:48,190
+ذلك في التفاصيل لاحقا، المستخدمين الذين يمتلكون
+
+628
+00:40:48,190 --> 00:40:52,730
+أكتر من المال، نرى أنني كنت مستخدم لـ 600 ألف
+
+629
+00:40:52,730 --> 00:40:55,050
+pound، 600 ألف pound،
+
+630
+00:40:57,610 --> 00:41:02,770
+أولئك الذين لديهم أقل من 400 ألف دولار لتخلص من
+
+631
+00:41:02,770 --> 00:41:07,190
+المال والباقين من المستخدمين لم يكنوا مهتمين بهم
+
+632
+00:41:07,190 --> 00:41:14,470
+بشكل كبير، يجب أن يقبلوا تقرار مثل هذا يمكننا
+
+633
+00:41:14,470 --> 00:41:19,820
+أن نجرح ما لدينا بقول أن لدينا إخلاصعن طريق
+
+634
+00:41:19,820 --> 00:41:24,800
+التعامل مرة أخرى فقط رأينا أننا لدينا مجموعة غير
+
+635
+00:41:24,800 --> 00:41:28,240
+مجرم للشركات كما قلت قبلها ليس هناك شيء جديد هنا
+
+636
+00:41:28,240 --> 00:41:31,820
+ولكن في المرة التالية يجب أن ننظر إلى الفترة في
+
+637
+00:41:31,820 --> 00:41:33,980
+الولايات المتحدة في التي لدينا الكثير من المعلومات
+
+638
+00:41:33,980 --> 00:41:38,420
+يجب أن ننظر إلى التفاصيل التفاصيل نحن لدينا
+
+639
+00:41:38,420 --> 00:41:44,800
+التعامل ونحن لدينا التعامل التعامل يعني التعامل
+
+640
+00:41:44,800 --> 00:41:49,360
+مرة أخرى نفس الشيء في اللي هناوهيبقى the debtor to
+
+641
+00:41:49,360 --> 00:41:54,340
+allow him to use a future earningعشان انا ممكن
+
+642
+00:41:54,340 --> 00:41:56,660
+احصل من المال اللي احصل من المال اللي احصل من
+
+643
+00:41:56,660 --> 00:41:57,240
+المال اللي احصل من المال اللي احصل من المال اللي
+
+644
+00:41:57,240 --> 00:41:59,020
+احصل من المال اللي احصل من المال اللي احصل من
+
+645
+00:41:59,020 --> 00:41:59,700
+المال اللي احصل من المال اللي احصل من المال اللي
+
+646
+00:41:59,700 --> 00:41:59,840
+احصل من المال اللي احصل من المال اللي احصل من
+
+647
+00:41:59,840 --> 00:41:59,960
+المال اللي احصل من المال اللي احصل من المال اللي
+
+648
+00:41:59,960 --> 00:42:01,900
+احصل من المال اللي احصل من المال اللي احصل من
+
+649
+00:42:01,900 --> 00:42:02,500
+المال اللي احصل من المال اللي احصل من المال اللي
+
+650
+00:42:02,500 --> 00:42:03,340
+احصل من المال اللي احصل من المال اللي احصل من
+
+651
+00:42:03,340 --> 00:42:05,900
+المال اللي احصل من المال اللي احصل من المال اللي
+
+652
+00:42:05,900 --> 00:42:16,000
+احصل من المال اللي احصل من المال اللي
+
+653
+00:42:16,000 --> 00:42:16,220
+ا
+
+654
+00:42:23,130 --> 00:42:26,590
+يمكن أن تكون هناك سؤال مثل هذا يقول أن بعد أن نقوم
+
+655
+00:42:26,590 --> 00:42:30,230
+بإطلاق الانتجار الانتجار يوجد بعض المسؤلات على
+
+656
+00:42:30,230 --> 00:42:35,590
+البيانات ومسؤلات أخرى على الانتجار واحدة منها ..
+
+657
+00:42:35,590 --> 00:42:39,570
+هل أستطيع أن أقول؟ الانتجار لا يستطيع أن يجمع
+
+658
+00:42:39,570 --> 00:42:44,130
+المال من الخارج من المقالات الوحيد الوحيد الوحيد
+
+659
+00:42:44,130 --> 00:42:47,990
+من طريقة الانتجار أن يجمع المالالسلسلات او
+
+660
+00:42:47,990 --> 00:42:51,970
+الانفجار نحن لدينا فقط كما قلت واحد طريق وهو
+
+661
+00:42:51,970 --> 00:42:55,350
+الوحيد الطريق الانفجار لا يمكنه يطلب المال لا
+
+662
+00:42:55,350 --> 00:42:58,950
+يمكنك أن تذهب غير مفهوم لا يمكنك أن تذهب و تنظر في
+
+663
+00:42:58,950 --> 00:43:01,850
+الباب لا يمكنك أن تذهب لعبارة أخر لا يمكنك أن تذهب
+
+664
+00:43:01,850 --> 00:43:08,490
+للعبارة الوحيد الطريق هو السلسلات الانفجارالحكومة
+
+665
+00:43:08,490 --> 00:43:13,810
+لا تسمح للمستخدم الوظيفة التي تم إعلانها كجزء من
+
+666
+00:43:13,810 --> 00:43:17,130
+مجلس الحكومة لتقديم الوظيفة على نفس الوقت الوظيفة
+
+667
+00:43:17,130 --> 00:43:20,050
+لن تكون قادرة على تقديم الوظيفة على نفس الوقت
+
+668
+00:43:20,050 --> 00:43:23,230
+مثلًا، لنقول اليوم، لقد أعلننا اليوم أننا سنقوم
+
+669
+00:43:23,230 --> 00:43:28,110
+بالتغيير و سيكون لدينا مؤسسة مستخدم مستخدم مستخدم
+
+670
+00:43:28,110 --> 00:43:28,610
+مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم
+
+671
+00:43:28,610 --> 00:43:29,150
+مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم
+
+672
+00:43:29,150 --> 00:43:31,330
+مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم
+
+673
+00:43:31,330 --> 00:43:34,650
+مستخدم
+
+674
+00:43:37,690 --> 00:43:40,710
+فالدتر في هذه اللحظة لا يستطيع أن يبيع أي شيء حتى
+
+675
+00:43:40,710 --> 00:43:44,710
+لو كان في اسمه كل شيء كان في اسمه حتى تلك اللحظة
+
+676
+00:43:44,710 --> 00:43:50,990
+لا يستطيع أن يبيع أي شيء حتى لو كان في اسمه كل شيء
+
+677
+00:43:50,990 --> 00:43:54,810
+كان في اسمه كل شيء كان في اسمه كل شيء كان في اسمه
+
+678
+00:43:54,810 --> 00:43:54,810
+كل شيء كان في اسمه كل شيء كان في اسمه كل شيء كان
+
+679
+00:43:54,810 --> 00:43:54,810
+في اسمه كل شيء كان في اسمه كل شيء كان في اسمه كل
+
+680
+00:43:54,810 --> 00:43:54,810
+شيء كان في اسمه كل شيء كان في اسمه كل شيء كان في
+
+681
+00:43:54,810 --> 00:43:54,810
+اسمه كل شيء كان في اسمه كل شيء كان في اسمه كل شيء
+
+682
+00:43:54,810 --> 00:43:54,810
+كان في اسمه كل شيء كان في اسمه كل شيء كان في اسمه
+
+683
+00:43:54,810 --> 00:43:56,590
+كل شيء كان في اسمه كل شيء كان في اسمه كل شيء كان
+
+684
+00:43:56,590 --> 00:44:04,330
+في اسمه كل
+
+685
+00:44:04,330 --> 00:44:07,960
+شيء كان فيهو غير صحيح إذا كان المسلسل يريد أن يسحق
+
+686
+00:44:07,960 --> 00:44:10,400
+أي شيء بسبب حياته أو حياته أو حياته أو حياته أو
+
+687
+00:44:10,400 --> 00:44:11,040
+حياته أو حياته أو حياته أو حياته أو حياته أو حياته
+
+688
+00:44:11,040 --> 00:44:11,440
+أو حياته أو حياته أو حياته أو حياته أو حياته أو
+
+689
+00:44:11,440 --> 00:44:14,120
+حياته أو حياته أو حياته أو حياته أو حياته أو حياته
+
+690
+00:44:14,120 --> 00:44:14,500
+أو حياته أو حياته أو حياته أو حياته أو حياته أو
+
+691
+00:44:14,500 --> 00:44:15,640
+حياته أو حياته أو حياته أو حياته أو حياته أو حياته
+
+692
+00:44:15,640 --> 00:44:20,920
+أو حياته أو حياته أو حياته أو حياته أو حياته أو
+
+693
+00:44:20,920 --> 00:44:25,620
+حياته أو حياته
+
+694
+00:44:36,240 --> 00:44:42,280
+هي مجموعة مختلفة ومجموعة مختلفة ومجموعة مختلفة
+
+695
+00:44:42,280 --> 00:44:43,220
+ومجموعة مختلفة ومجموعة مختلفة ومجموعة مختلفة
+
+696
+00:44:43,220 --> 00:44:45,200
+ومجموعة مختلفة ومجموعة مختلفة ومجموعة مختلفة
+
+697
+00:44:45,200 --> 00:44:49,140
+ومجموعة مختلفة ومجموعة
+
+698
+00:44:49,140 --> 00:44:51,640
+مختلفة ومجموعة مختلفة ومجموعة مختلفة ومجموعة
+
+699
+00:44:51,640 --> 00:44:51,640
+مختلفة ومجموعة مختلفة ومجموعة مختلفة ومجموعة
+
+700
+00:44:51,640 --> 00:44:51,640
+مختلفة ومجموعة مختلفة ومجموعة مختلفة ومجموعة
+
+701
+00:44:51,640 --> 00:45:04,700
+مختلفة ومجموعة مختلفة ومجموعة مختلفة ومج
+
+702
+00:45:07,140 --> 00:45:12,400
+وهذه الاقتصاد يمكن أن يتم تحميله باستخدام
+
+703
+00:45:12,400 --> 00:45:16,560
+القواعد التي تم إستخدامها في الولايات المتحدة في
+
+704
+00:45:16,560 --> 00:45:18,260
+الواقع في الواقع في الولايات المتحدة في الولايات
+
+705
+00:45:18,260 --> 00:45:19,620
+المتحدة في الولايات المتحدة في الولايات المتحدة في
+
+706
+00:45:19,620 --> 00:45:20,680
+الولايات المتحدة في الولايات المتحدة في الولايات
+
+707
+00:45:20,680 --> 00:45:23,600
+المتحدة في الولايات المتحدة في الولايات المتحدة في
+
+708
+00:45:23,600 --> 00:45:24,600
+الولايات المتحدة في الولايات المتحدة في الولايات
+
+709
+00:45:24,600 --> 00:45:25,880
+المتحدة في الولايات المتحدة في الولايات المتحدة في
+
+710
+00:45:25,880 --> 00:45:26,940
+الولايات المتحدة في الولايات المتحدة في الولايات
+
+711
+00:45:26,940 --> 00:45:30,520
+المتحدة في الولايات المتحدة في الولايات المتحدة في
+
+712
+00:45:30,630 --> 00:45:32,470
+They look like the same, there's not much
+
+713
+00:45:32,470 --> 00:45:34,550
+difference between them. Dealing with debts,
+
+714
+00:45:35,290 --> 00:45:37,250
+debtors cannot be .. as I said we have debt,
+
+715
+00:45:37,710 --> 00:45:41,430
+debtors, payments. Somebody cannot pay his debts
+
+716
+00:45:41,430 --> 00:45:45,530
+and it's optional. We said before that we have
+
+717
+00:45:45,530 --> 00:45:48,270
+voluntary and involuntary
+
+718
+00:45:50,120 --> 00:45:52,820
+هو افضل، انت ممكن تفعيله، اذا كنت تريد أن تدفع
+
+719
+00:45:52,820 --> 00:45:55,120
+المال، يمكنك أن تدفعه، اذا كنت تريد ان تعمل عمل
+
+720
+00:45:55,120 --> 00:45:57,460
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+721
+00:45:57,460 --> 00:45:58,340
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+722
+00:45:58,340 --> 00:45:59,000
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+723
+00:45:59,000 --> 00:45:59,000
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+724
+00:45:59,000 --> 00:45:59,360
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+725
+00:45:59,360 --> 00:45:59,460
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+726
+00:45:59,460 --> 00:46:08,320
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+727
+00:46:08,320 --> 00:46:17,600
+ع
+
+728
+00:46:19,160 --> 00:46:23,680
+ولكن حتى هذا الانتقال الجديد مجرد بعض الانقلاجات
+
+729
+00:46:23,680 --> 00:46:29,280
+وعندما تكون لديك الانتقال وحرية وعندما تريد أن
+
+730
+00:46:29,280 --> 00:46:32,960
+تعود للعمل في المستقبل يمكنك أن تعود للعمل بالطبع
+
+731
+00:46:32,960 --> 00:46:37,520
+يمكنك أن تطلب المسمح للمجلد ويمكنك أن تعود للعمل
+
+732
+00:46:37,520 --> 00:46:41,960
+ولكن في هذه اللحظة لن تكون لديك حرية تمامة لديك
+
+733
+00:46:41,960 --> 00:46:45,740
+بعض الانقلاجات لأنك كنت مخطط في الماضي فإذا كنت
+
+734
+00:46:45,740 --> 00:46:49,930
+تريد أن تكون لديك انتقال جديدrestriction في قيود
+
+735
+00:46:49,930 --> 00:46:54,610
+and as we said before that we have the assets
+
+736
+00:46:54,610 --> 00:46:59,010
+shared fairly between creditors and there's
+
+737
+00:46:59,010 --> 00:47:02,050
+something I want you to focus on here look first
+
+738
+00:47:02,050 --> 00:47:07,290
+-time bankrupts يا حنين first-time bankrupt was
+
+739
+00:47:07,290 --> 00:47:11,090
+given when the general receive their their just
+
+740
+00:47:11,090 --> 00:47:15,870
+discharge one year after the death of the bankrupt
+
+741
+00:47:15,870 --> 00:47:16,350
+CEO
+
+742
+00:47:22,190 --> 00:47:27,990
+هو حسنًا، دعنا نقول هذا، يجب أن نطلق حرص الانفجار،
+
+743
+00:47:27,990 --> 00:47:33,630
+كانت القرار مجرد قرار مجرد
+
+744
+00:47:33,630 --> 00:47:35,490
+حرص الانفجار، كانت القرار مجرد حرص الانفجار، كانت
+
+745
+00:47:35,490 --> 00:47:35,490
+القرار مجرد حرص الانفجار، كانت القرار مجرد حرص
+
+746
+00:47:35,490 --> 00:47:35,490
+الانفجار، كانت القرار مجرد حرص الانفجار، كانت
+
+747
+00:47:35,490 --> 00:47:35,510
+القرار مجرد حرص الانفجار، كانت القرار مجرد حرص
+
+748
+00:47:35,510 --> 00:47:37,490
+الانفجار، كانت القرار مجرد حرص الانفجار، كانت
+
+749
+00:47:37,490 --> 00:47:41,750
+القرار مجرد حرص الانفجار، كانت القرار مجرد حرص
+
+750
+00:47:41,750 --> 00:47:49,210
+الانفجار،
+
+751
+00:47:49,210 --> 00:47:53,260
+كانت القراريستطيع أن يأخذ وقت طويل يستطيع أن يأخذ
+
+752
+00:47:53,260 --> 00:47:54,500
+وقت طويل يستطيع أن يأخذ وقت طويل يستطيع أن يأخذ
+
+753
+00:47:54,500 --> 00:47:57,760
+وقت طويل يستطيع أن يأخذ وقت طويل يستطيع أن يأخذ
+
+754
+00:47:57,760 --> 00:47:59,000
+وقت طويل يستطيع أن يأخذ وقت طويل يستطيع أن يأخذ
+
+755
+00:47:59,000 --> 00:47:59,720
+وقت طويل يستطيع أن يأخذ وقت طويل يستطيع أن يأخذ
+
+756
+00:47:59,720 --> 00:48:02,440
+وقت طويل يستطيع أن يأخذ وقت طويل يستطيع أن يأخذ
+
+757
+00:48:02,440 --> 00:48:03,700
+وقت طويل يستطيع أن يأخذ وقت طويل يستطيع أن يأخذ
+
+758
+00:48:03,700 --> 00:48:07,000
+وقت طويل يستطيع أن يأخذ وقت طويل يستطيع أن يأخذ
+
+759
+00:48:07,000 --> 00:48:12,400
+وقت
+
+760
+00:48:12,400 --> 00:48:16,130
+طويلاليوم لديك حكومة و إعفار فيه قرار خلاص حكومة
+
+761
+00:48:16,130 --> 00:48:19,710
+لفلاس it takes one year to have a district court
+
+762
+00:48:19,710 --> 00:48:23,050
+اعفار I mean within this time from this time to
+
+763
+00:48:23,050 --> 00:48:27,750
+this time let's say from 2000 2001
+
+764
+00:48:27,750 --> 00:48:32,090
+one year within this 12 month any money any extra
+
+765
+00:48:32,090 --> 00:48:35,710
+money you have you have to give it to the trustee
+
+766
+00:48:35,710 --> 00:48:39,130
+this it means any extra money I have within this
+
+767
+00:48:39,130 --> 00:48:45,770
+12 monthالأكثر المال يجب أن أعطيه للحكومة بعد 12
+
+768
+00:48:45,770 --> 00:48:49,370
+أشهر بعد أن نحصل على هذه الحاجة أي أكتر المال يجب
+
+769
+00:48:49,370 --> 00:48:52,950
+أن أعطيه هو مني لا أحد يستطيع أن يسألني بعض
+
+770
+00:48:52,950 --> 00:48:58,770
+الأحيان يستغرق أكتر من سنة يستغرق 2,3,4,5 يستغرق
+
+771
+00:48:58,770 --> 00:49:05,750
+إذا كانت أخر مرة يستغرق عدد المال يستغرق
+
+772
+00:49:05,750 --> 00:49:09,060
+عدد الحكومةبالنسبة للمدرسة أيضًا ثم يمكن أن يكون
+
+773
+00:49:09,060 --> 00:49:12,740
+هناك شيء يسمى في نهاية اليوم انسلفانية تتعامل مع
+
+774
+00:49:12,740 --> 00:49:16,920
+انسلفانية انسلفانية في هذه الحالة انسلفانية يعني
+
+775
+00:49:16,920 --> 00:49:22,260
+انسلفانية و انا قلت اذا كنا نقول انسلفانية أكتر من
+
+776
+00:49:22,260 --> 00:49:27,040
+الوقت يعني انسلفانية انسلفانية و حتى في مجتمع هنا
+
+777
+00:49:27,040 --> 00:49:32,180
+الناس يقولون انسلفانية يعني انسلفانية يعني
+
+778
+00:49:32,180 --> 00:49:37,540
+انسلفانية ليس تحويلبالنسبة لـ Insolvency لديه
+
+779
+00:49:37,540 --> 00:49:45,680
+Stigma سوف ننظر في المرة القادمة على الانهيار كيف
+
+780
+00:49:45,680 --> 00:49:53,080
+يمكنه أن يشعر بالانهيار In the UK أيضًا لديهم
+
+781
+00:49:53,080 --> 00:49:57,180
+تغيير للانهيار الانهيار الانهيار الانهيار الانهيار
+
+782
+00:49:57,180 --> 00:50:04,680
+الانهيار الانهيار الانهيار الانهيار الانهيار
+
+783
+00:50:05,790 --> 00:50:09,990
+هذه افتراضية وهي متساوية لـ Reorganization في
+
+784
+00:50:09,990 --> 00:50:13,150
+الولايات المتحدة نسميها Reorganization في الولايات
+
+785
+00:50:13,150 --> 00:50:16,350
+المتحدة نسميها IVA Individual Voluntary
+
+786
+00:50:16,350 --> 00:50:22,670
+Arrangement هو يعني تسوير هو عادة جدولة نفس الشيء
+
+787
+00:50:22,670 --> 00:50:26,390
+ننظر
+
+788
+00:50:26,390 --> 00:50:30,470
+إلى الاختصاراتالسلسلات اللي لديها ليست نفسها،
+
+789
+00:50:30,470 --> 00:50:34,930
+تتعامل مع حالتها، تتعامل مع المال اللي لدينا،
+
+790
+00:50:34,930 --> 00:50:39,930
+تتعامل مع موقعنا، تتعامل مع ما لدينا هنا، كما ترى،
+
+791
+00:50:39,930 --> 00:50:43,910
+لدينا السلسلات الانفجارية ليست نفسها، لكنها يمكن
+
+792
+00:50:43,910 --> 00:50:46,990
+أن تكون في بعض الأحيان مستخدمة أو غير مستخدمة أو
+
+793
+00:50:46,990 --> 00:50:50,970
+IVA كما لدينا قبل ذلك، مستخدمة أو غير مستخدمة يعني
+
+794
+00:50:52,500 --> 00:50:55,460
+بالإضافة لـ Bankruptcy Petition التي تم إضافتها
+
+795
+00:50:55,460 --> 00:50:59,420
+الـ Data بمجرد ذلك بمجرد ذلك بمجرد ذلك بمجرد ذلك
+
+796
+00:50:59,420 --> 00:50:59,420
+بمجرد ذلك بمجرد ذلك بمجرد ذلك بمجرد ذلك بمجرد ذالك
+
+797
+00:50:59,420 --> 00:51:03,520
+بمجرد ذالك بمجرد ذالك بمجرد ذالك بمجرد ذالك بمجرد
+
+798
+00:51:03,520 --> 00:51:05,100
+ذالك بمجرد ذالك بمجرد ذالك بمجرد ذالك بمجرد ذالك
+
+799
+00:51:05,100 --> 00:51:05,120
+بمجرد ذالك بمجرد ذالك بمجرد ذالك بمجرد ذالك بمجرد
+
+800
+00:51:05,120 --> 00:51:07,040
+ذالك بمجرد ذالك بمجرد ذالك بمجرد ذالك ب
+
+801
+00:51:24,730 --> 00:51:27,830
+طبعا تقول انك تستطيع الاستخدام اذا كنت قد قدر
+
+802
+00:51:27,830 --> 00:51:31,190
+المدينة
+
+803
+00:51:31,190 --> 00:51:31,630
+ان تستخدم المدينة اذا كنت قدر المدينة ان تستخدم
+
+804
+00:51:31,630 --> 00:51:33,810
+المدينة اذا كنت قدر المدينة ان تستخدم المدينة اذا
+
+805
+00:51:33,810 --> 00:51:34,130
+كنت قدر المدينة ان تستخدم المدينة اذا كنت قدر
+
+806
+00:51:34,130 --> 00:51:34,810
+المدينة ان تستخدم المدينة اذا كنت قدر المدينة ان
+
+807
+00:51:34,810 --> 00:51:35,430
+تستخدم المدينة اذا كنت قدر المدينة ان تستخدم
+
+808
+00:51:35,430 --> 00:51:37,450
+المدينة اذا كنت قدر المدينة ان تستخدم المدينة اذا
+
+809
+00:51:37,450 --> 00:51:39,410
+كنت قدر المدينة ان تستخدم المدينة اذا كنت قدر
+
+810
+00:51:39,410 --> 00:51:49,670
+المدينة ان تستخدم المدينة اذا
+
+811
+00:51:49,670 --> 00:51:57,330
+كنت قلا نستطيع أن نقول لا كدتر انا لن اقف هنا انا
+
+812
+00:51:57,330 --> 00:52:01,710
+سأجعله يتعامل بالكامل الدتر يجب أن يتعامل بالكامل
+
+813
+00:52:01,710 --> 00:52:06,530
+مع الاختصارات اذا لم يتعامل الدتر يعني انه ليس
+
+814
+00:52:06,530 --> 00:52:13,450
+صادق انه ليس صادق وإذا لم يكن صادق او صادق فإن
+
+815
+00:52:13,450 --> 00:52:15,390
+الاختصار صح
+
+816
+00:52:18,280 --> 00:52:22,480
+هو ضده، فهو لن يكون حتى مرحبًا، فهو لن يكون لديه
+
+817
+00:52:22,480 --> 00:52:27,360
+هذه التاريخة، لذلك عندما يبدأ التقاليد، فيجب أن
+
+818
+00:52:27,360 --> 00:52:32,100
+يكون المدير يتعامل تمامًا. إذا أسأل الشرطة أن يقوم
+
+819
+00:52:32,100 --> 00:52:34,920
+بإجابته، يجب أن تقوم بذلك. إذا كان عليك أن تحضر
+
+820
+00:52:34,920 --> 00:52:37,680
+مصطلحة، مصطلحة البنك، يجب أن تحضر مصطلحة البنك.
+
+821
+00:52:39,600 --> 00:52:44,280
+إذا كان عليك أن تشرح أي مقال، يجب أن تشرحه. لا
+
+822
+00:52:44,280 --> 00:52:46,560
+يمكنك أن تقول، لا يمكنك أن تقول لا.
+
+823
+00:52:53,710 --> 00:52:59,390
+البرنامج تبدأ بإصلاح الانقلاب الانقلاب الانقلاب
+
+824
+00:52:59,390 --> 00:53:02,690
+الانقلاب الانقلاب الانقلاب الانقلاب الانقلاب
+
+825
+00:53:02,690 --> 00:53:03,590
+الانقلاب الانقلاب الانقلاب الانقلاب الانقلاب
+
+826
+00:53:03,590 --> 00:53:04,230
+الانقلاب الانقلاب الانقلاب الانقلاب الانقلاب
+
+827
+00:53:04,230 --> 00:53:05,470
+الانقلاب الانقلاب الانقلاب الانقلاب الانقلاب
+
+828
+00:53:05,470 --> 00:53:05,470
+الانقلاب الانقلاب الانقلاب الانقلاب الانقلاب
+
+829
+00:53:05,470 --> 00:53:05,470
+الانقلاب الانقلاب الانقلاب الانقلاب الانقلاب
+
+830
+00:53:05,470 --> 00:53:05,990
+الانقلاب الانقلاب الانقلاب الانقلاب الانقلاب
+
+831
+00:53:05,990 --> 00:53:10,980
+الانقلاب الانقلاب الانقلاب الانقلاب الالثاني هو
+
+832
+00:53:10,980 --> 00:53:16,200
+يجمع المال و الأسات التي يمكنه شرحها و يمكنه جمع
+
+833
+00:53:16,200 --> 00:53:22,580
+كل شيء مفيد عن الجزء الاجتماعي من المال في حياته و
+
+834
+00:53:22,580 --> 00:53:25,960
+من هنا نستطيع أن نبدأ حتى نحصل على القرار الأخير
+
+835
+00:53:25,960 --> 00:53:30,000
+لتحرير الأمر حتى نحصل على تحرير المساعدة هذه هي
+
+836
+00:53:30,000 --> 00:53:36,990
+الاختصاراتنستطيع أن نفعلها بإيقاف تسوية نستطيع أن
+
+837
+00:53:36,990 --> 00:53:40,830
+نصل إلى تسوية تسوية تسوية تستطيع أن تكون بين دتر
+
+838
+00:53:40,830 --> 00:53:45,190
+وكريلتر وعندما نصل إلى تسوية تسوية تسوية تستطيع أن
+
+839
+00:53:45,190 --> 00:53:47,490
+نصل إلى تسوية تسوية تسوية تسوية تستطيع أن نصل إلى
+
+840
+00:53:47,490 --> 00:53:49,090
+تسوية تسوية تسوية تسوية تسوية تسوية تسوية تسوية
+
+841
+00:53:49,090 --> 00:53:49,970
+تسوية تسوية تسوية تسوية تسوية تسوية تسوية تسوية
+
+842
+00:53:49,970 --> 00:53:49,970
+تسوية تسوية تسوية تسوية تسوية تسوية تسوية تسوية
+
+843
+00:53:49,970 --> 00:53:53,610
+تسوية تسوية تسوية تسوية تسوية
+
+844
+00:53:53,610 --> 00:54:00,370
+تس
+
+845
+00:54:01,310 --> 00:54:05,350
+هذه الأفعال .. بالطبع عندما تطلع لتطبيق مغامرة إذا
+
+846
+00:54:05,350 --> 00:54:08,810
+كنت ترغب في تطبيق أي شيء .. إذا قمت بإطلاق أي طلب
+
+847
+00:54:08,810 --> 00:54:13,290
+للحكومة .. حتى إذا لم يكن مغامرة .. على حق .. يجب
+
+848
+00:54:13,290 --> 00:54:16,710
+أن تقوم بإطلاق الأفعال .. في بلسترنك الأفعال يجب
+
+849
+00:54:16,710 --> 00:54:21,550
+أن تكون 1% من المال .. كم هي؟ في الولايات المتحدة،
+
+850
+00:54:21,550 --> 00:54:29,290
+يقول الحكومة أن أفعال الحكومة 120 ريالوهي لا شيء
+
+851
+00:54:29,290 --> 00:54:32,970
+فقط قليل من المال و أحيانا و حتى أحيانا يمكن أن
+
+852
+00:54:32,970 --> 00:54:39,850
+يكون هذا الـ £120 هنا مخرج
+
+853
+00:54:39,850 --> 00:54:42,930
+من هنا، لماذا؟ لأن إذا لم يكن لديك إيقاف و إذا كان
+
+854
+00:54:42,930 --> 00:54:49,380
+هذا الـكان على مدارس الدولة والدولة كانت مستغربة
+
+855
+00:54:49,380 --> 00:54:53,220
+من الدولة هو لا يحصل على المال الناس في اليوكي
+
+856
+00:54:53,220 --> 00:54:57,160
+اللي لا يملكوا المال اللي لا يعملوا لا يعملوا
+
+857
+00:54:57,160 --> 00:54:59,820
+يمكنهم أن يحصلوا على شيء يسمى مدارس الدولة والدولة
+
+858
+00:54:59,820 --> 00:55:02,740
+والدولة هي مدارس الدولة والدولة هي مدارس الدولة
+
+859
+00:55:02,740 --> 00:55:05,400
+والدولة هي مدارس الدولة هي مدارس الدولة هي مدارس
+
+860
+00:55:05,400 --> 00:55:05,900
+الدولة هي مدارس الدولة هي مدارس الدولة هي مدارس
+
+861
+00:55:05,900 --> 00:55:06,460
+الدولة هي مدارس الدولة هي مدارس الدولة هي مدارس
+
+862
+00:55:06,460 --> 00:55:06,560
+الدولة هي مدارس الدولة هي مدارس الدولة هي مدارس
+
+863
+00:55:06,560 --> 00:55:10,770
+الدولة هي مدارس الدولة هي مدارس الدreleased from
+
+864
+00:55:10,770 --> 00:55:13,050
+the amount of money which has to be paid as court
+
+865
+00:55:13,050 --> 00:55:16,230
+fees and there's something called deposit which is
+
+866
+00:55:16,230 --> 00:55:19,950
+250 this is not so important for you anyway once
+
+867
+00:55:19,950 --> 00:55:21,930
+you are in the UK you should know how much you
+
+868
+00:55:21,930 --> 00:55:24,270
+should pay for the court fees I mean at least you
+
+869
+00:55:24,270 --> 00:55:26,370
+have to know and even here sometimes you have to
+
+870
+00:55:26,370 --> 00:55:30,570
+be a statement of fear for the swear swear of a
+
+871
+00:55:30,570 --> 00:55:33,070
+statement of affairs حلفي اليمين there's some
+
+872
+00:55:33,070 --> 00:55:38,490
+money have to be paid with theمع المطالب اذا اتت
+
+873
+00:55:38,490 --> 00:55:41,590
+اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت
+
+874
+00:55:41,590 --> 00:55:43,490
+اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت
+
+875
+00:55:43,490 --> 00:55:46,970
+اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت
+
+876
+00:55:46,970 --> 00:55:47,370
+اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت
+
+877
+00:55:47,370 --> 00:55:48,690
+اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت
+
+878
+00:55:48,690 --> 00:55:48,790
+اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت اتت
+
+879
+00:56:06,270 --> 00:56:08,930
+والثاني هو join petitions وعندما يكون لديهم job
+
+880
+00:56:08,930 --> 00:56:12,330
+petition فهي فقط فائقة واحدة وإلا كل واحد منهم
+
+881
+00:56:12,330 --> 00:56:17,200
+يحتاج إلى فائقة مختلفة شكرا لوقتكAlternative
+
+882
+00:56:17,200 --> 00:56:21,580
+dispute resolution arbitration. Arbitration is a
+
+883
+00:56:21,580 --> 00:56:26,320
+form of alternative dispute resolution and it's a
+
+884
+00:56:26,320 --> 00:56:31,520
+legal technique that used to resolve the dispute
+
+885
+00:56:31,520 --> 00:56:40,110
+outside the courtsهو يقوم بتحديث لإحدى أو أكثر
+
+886
+00:56:40,110 --> 00:56:46,710
+شخصين من الانتخابين. إنها تقليد تقنيات في الواقع
+
+887
+00:56:46,710 --> 00:56:48,330
+في الواقع تقليد تقليد تقنيات في الواقع تقليد تقليد
+
+888
+00:56:48,330 --> 00:56:51,430
+تقليد تقليد تقليد تقليد تقليد تقليد تقليد تقليد
+
+889
+00:56:51,430 --> 00:56:52,650
+تقليد تقليد تقليد تقليد تقليد تقليد تقليد تقليد
+
+890
+00:56:52,650 --> 00:56:53,050
+تقليد تقليد تقليد تقليد تقليد تقليد تقليد تقليد
+
+891
+00:56:53,050 --> 00:56:53,690
+تقليد تقليد تقليد تقليد تقليد تقليد تقليد تقليد
+
+892
+00:56:53,690 --> 00:56:58,430
+تقليد تقليد تقليد تقليد تقليد تقForms of
+
+893
+00:56:58,430 --> 00:57:02,370
+arbitration, mediations that a form of settlement
+
+894
+00:57:02,370 --> 00:57:06,350
+negotiation facilitated by a natural third party,
+
+895
+00:57:06,730 --> 00:57:10,650
+non-binding resolution
+
+896
+00:57:10,650 --> 00:57:14,950
+that applied
+
+897
+00:57:14,950 --> 00:57:19,870
+by who have a previous experience, voluntary or
+
+898
+00:57:19,870 --> 00:57:20,330
+mandatory
+
+899
+00:57:23,340 --> 00:57:26,460
+advantages and disadvantages advantages of
+
+900
+00:57:26,460 --> 00:57:30,440
+arbitration is often faster than litigation in
+
+901
+00:57:30,440 --> 00:57:33,820
+court and it can be cheaper and more flexible for
+
+902
+00:57:33,820 --> 00:57:37,160
+business and it's generally easier for enforced
+
+903
+00:57:37,160 --> 00:57:40,620
+than court judgments disadvantages
+
+904
+00:57:43,190 --> 00:57:47,270
+إذا كانت التجارب مجلسية ومدعومة، فإن الشركات لديها
+
+905
+00:57:47,270 --> 00:57:52,490
+حقوق لتساعد الحكومة وتجاربها لتقرر القضية. في بعض
+
+906
+00:57:52,490 --> 00:57:56,530
+التجارب التجاربية، يحتاج الشركات للدفع لتجارب
+
+907
+00:57:56,530 --> 00:57:57,670
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+908
+00:57:57,670 --> 00:57:57,670
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+909
+00:57:57,670 --> 00:57:57,670
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+910
+00:57:57,670 --> 00:57:58,410
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+911
+00:57:58,410 --> 00:58:01,170
+تجارب تجارب تجارب
+
+912
+00:58:04,570 --> 00:58:10,730
+التعاملات التجارية التجارية هي عملية تجارة تجارة
+
+913
+00:58:10,730 --> 00:58:13,290
+تجارة تجارة تجارة تجارة تجارة تجارة تجارة تجارة
+
+914
+00:58:13,290 --> 00:58:15,330
+تجارة تجارة تجارة تجارة تجارة تجارة تجارة تجارة
+
+915
+00:58:15,330 --> 00:58:15,690
+تجارة تجارة تجارة تجارة تجارة تجارة تجارة تجارة
+
+916
+00:58:15,690 --> 00:58:15,870
+تجارة تجارة تجارة تجارة تجارة تجارة تجارة تجارة
+
+917
+00:58:15,870 --> 00:58:18,190
+تجارة تجارة تجارة تجارة تجارة تجارة تجارة تجارة
+
+918
+00:58:18,190 --> 00:58:24,990
+تجارة تجارة تجارة تجارة تجارة تجارة تجارة تجارة
+
+919
+00:58:24,990 --> 00:58:29,570
+تجارة تج
+
+920
+00:58:30,620 --> 00:58:33,500
+type of agreements agreements which provide that
+
+921
+00:58:33,500 --> 00:58:36,560
+if a dispute should arise it will be resolved by
+
+922
+00:58:36,560 --> 00:58:40,360
+arbitration this will generally be normal contract
+
+923
+00:58:40,360 --> 00:58:42,960
+agreements which are signed after dispute has
+
+924
+00:58:42,960 --> 00:58:46,560
+reason agreeing that the dispute should be
+
+925
+00:58:46,560 --> 00:58:52,800
+resolved by arbitration and
+
+926
+00:58:52,800 --> 00:58:55,540
+now I will continue about and talk about the
+
+927
+00:58:55,540 --> 00:59:00,300
+applicable lawعندما نتكلم عن القوة المفترضة، القوة
+
+928
+00:59:00,300 --> 00:59:04,940
+تتحكم في اتفاق الانتخابات والقوة تتحكم في
+
+929
+00:59:04,940 --> 00:59:09,500
+الانتخابات ومقالاتها والقوة تتحكم في الانتخابات
+
+930
+00:59:09,500 --> 00:59:11,040
+ومقالاتها والقوة تتحكم في الانتخابات ومقالاتها
+
+931
+00:59:11,040 --> 00:59:14,840
+والقوة تتحكم في الانتخابات والقوة تتحكم في
+
+932
+00:59:14,840 --> 00:59:15,700
+الانتخابات والقوة تتحكم في الانتخابات والقوة تتحكم
+
+933
+00:59:15,700 --> 00:59:17,940
+في الانتخابات والقوة تتحكم في الانتخابات والقوة
+
+934
+00:59:17,940 --> 00:59:21,680
+تتحكم في الانتخابات والقوة تتحكم في الانتخابات
+
+935
+00:59:21,680 --> 00:59:24,810
+والقوة تتحكم في الانتخابات والقوة توالفعل بإن
+
+936
+00:59:24,810 --> 00:59:32,210
+اتفاق الانتخابات اتفاق الرئيسي اتفاق
+
+937
+00:59:32,210 --> 00:59:38,010
+الانتخابات اتفاق الرئيسي اتفاق الرئيسي اتفاق
+
+938
+00:59:38,010 --> 00:59:38,030
+الرئيسي اتفاق الرئيسي اتفاق الرئيسي اتفاق الرئيسي
+
+939
+00:59:38,030 --> 00:59:39,750
+اتفاق الرئيسي اتفاق الرئيسي اتفاق الرئيسي اتفاق
+
+940
+00:59:39,750 --> 00:59:39,830
+الرئيسي اتفاق الرئيسي اتفاق الرئيسي اتفاق الرئيسي
+
+941
+00:59:39,830 --> 00:59:42,730
+اتفاق الرئيسي اتفاق الرئيسي اتفاق الرئيسي اتفاق
+
+942
+00:59:42,730 --> 00:59:51,370
+الرئيسي اتفاق الرئيسي
+
+943
+00:59:51,370 --> 00:59:56,500
+اتفاقوالقانون المطلوبة للسلسلة، الامر الأساسي
+
+944
+00:59:56,500 --> 01:00:03,200
+للسلسلة مستخدم من قانون السلسلة للتجارب وربما
+
+945
+01:00:03,200 --> 01:00:06,880
+قرارًا من مصادرها إلى الحكومة التعامل معها عادة
+
+946
+01:00:06,880 --> 01:00:12,340
+تدفع هذه القانون لخيارات تجارب أو خيارات مختلفة
+
+947
+01:00:12,360 --> 01:00:16,700
+القانون التجارية التحقيقية القوة التحقيقية المشكلة
+
+948
+01:00:16,700 --> 01:00:17,380
+المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة
+
+949
+01:00:17,380 --> 01:00:17,780
+المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة
+
+950
+01:00:17,780 --> 01:00:19,740
+المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة
+
+951
+01:00:19,740 --> 01:00:20,520
+المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة
+
+952
+01:00:20,520 --> 01:00:21,780
+المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة
+
+953
+01:00:21,780 --> 01:00:21,820
+المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة
+
+954
+01:00:21,820 --> 01:00:22,360
+المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة
+
+955
+01:00:22,360 --> 01:00:24,320
+المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة
+
+956
+01:00:24,320 --> 01:00:34,740
+المشكلة المشكلThe term it's used to denote the
+
+957
+01:00:34,740 --> 01:00:40,080
+arbitrators sitting to determine the disparate
+
+958
+01:00:40,080 --> 01:00:44,100
+compensations of the arbitrator can vary
+
+959
+01:00:44,100 --> 01:00:50,820
+enormously with either a soleالتحريرين مع أو بدون
+
+960
+01:00:50,820 --> 01:00:56,200
+تأكيد وكثير من التعاملات مع بعضهم البعض في أكتر من
+
+961
+01:00:56,200 --> 01:01:02,500
+التحريكات والتحرير يستمتع بالانتقال من المساعدة
+
+962
+01:01:02,500 --> 01:01:08,050
+لأي شيء قمت أو فعلهLaw applicable to substance,
+
+963
+01:01:08,490 --> 01:01:12,090
+parties in a commercial dispute will often choose
+
+964
+01:01:12,090 --> 01:01:16,190
+the law applicable to the substance of their
+
+965
+01:01:16,190 --> 01:01:19,210
+dispute and in fact they are more likely to choose
+
+966
+01:01:19,210 --> 01:01:21,950
+substance .. substance .. okay I will talk about
+
+967
+01:01:21,950 --> 01:01:24,610
+for kids entertainment TV, I think everyone knows
+
+968
+01:01:24,610 --> 01:01:29,070
+about it, it's for animation .. for animeلتصنع
+
+969
+01:01:29,070 --> 01:01:36,110
+وتشريح المصادر على التليفزيون وكانت صفحة لتنهيئة
+
+970
+01:01:36,110 --> 01:01:44,570
+في هذا العام في 2012 صفحة لتنهيئة Chapter 11بعض ال
+
+971
+01:01:44,570 --> 01:01:48,370
+company four kids entertainment company known as
+
+972
+01:01:48,370 --> 01:01:52,110
+four kids is an American films and television
+
+973
+01:01:52,110 --> 01:01:58,430
+production company in bankruptcy since 2011 this
+
+974
+01:01:58,430 --> 01:02:03,270
+year it is known for English dubbing Japanese
+
+975
+01:02:03,270 --> 01:02:09,570
+animesوالخاصة في استخدام تصميم وتصميم التطبيقات
+
+976
+01:02:09,570 --> 01:02:14,610
+للأطفال في الانترنت وحول الولايات المتحدة وحول
+
+977
+01:02:14,610 --> 01:02:20,830
+العالم كالمجتمع فوركتز انترنت لديه مقاطع مخصصة في
+
+978
+01:02:20,830 --> 01:02:29,760
+الساعة السادسة في مدينة نيويورك ومشروع فوركتزوهو
+
+979
+01:02:29,760 --> 01:02:34,200
+مجتمعه في مبنى مختلفه في مانهاتون في نيويورك مجتمع
+
+980
+01:02:34,200 --> 01:02:40,100
+أسعار لطفولتهم NYSEKDA
+
+981
+01:02:40,100 --> 01:02:48,670
+في 1 يونيو 2010في 6 أبريل 2000 و 11 اتفال لـ
+
+982
+01:02:48,670 --> 01:02:53,470
+Chapter 11 Bankruptcy, Protection Following The
+
+983
+01:02:53,470 --> 01:02:57,590
+Lawsuit Concerning The UGF Franchise, it's an
+
+984
+01:02:57,590 --> 01:03:03,070
+animation that every one of us have watched since
+
+985
+01:03:03,070 --> 01:03:03,910
+we were kids
+
+986
+01:03:07,780 --> 01:03:11,440
+هي رقم مصادر الـ 4Kids ومصادره الـ 4Kids
+
+987
+01:03:11,440 --> 01:03:17,380
+Entertainment مصادر مختلفة من أجهزة التلفاز إلى
+
+988
+01:03:17,380 --> 01:03:21,680
+أجهزة التليفزيون إلى أجهزة الألعاب التي تدعم مصادر
+
+989
+01:03:21,680 --> 01:03:25,360
+الـ Royal Air Force 4Kids تركز على مصادر المحتوى
+
+990
+01:03:25,360 --> 01:03:27,380
+للأطفال ومعالم البريطانية
+
+991
+01:03:30,390 --> 01:03:35,090
+انها لطفان و فتاعتان كثير من مقالاتها تأتي من
+
+992
+01:03:35,090 --> 01:03:39,810
+مدخلات جيبانية أنمي مثلًا مثلًا مثلًا مثلًا مثلًا
+
+993
+01:03:39,810 --> 01:03:44,890
+مثلًا مثلًا
+
+994
+01:03:44,890 --> 01:03:52,130
+مثلًا
+
+995
+01:03:52,130 --> 01:03:56,410
+مثلًا مثلًا مثلًا
+
+996
+01:03:56,410 --> 01:03:58,950
+مثلًا
+
+997
+01:04:01,250 --> 01:04:07,030
+الـ CW of four kids الـ CW هي مجموعة من CBS و
+
+998
+01:04:07,030 --> 01:04:12,370
+Warner Brothers و Warner Brothers و CBS أعلنوا أن
+
+999
+01:04:12,370 --> 01:04:17,910
+الأطفال الـ WB و Warner Brothers كانوا برنامج
+
+1000
+01:04:17,910 --> 01:04:22,790
+مجموعة مجموعة و لا يمكن أن يصنعوا أكتر من التلفاز
+
+1001
+01:04:22,790 --> 01:04:26,790
+و المنزل و الأسلحة الكابلية بسبب مجموعة
+
+1002
+01:04:31,440 --> 01:04:34,360
+مشكلة كبيرة كانت .. كانت .. كانت .. كانت .. كانت
+
+1003
+01:04:34,360 --> 01:04:35,840
+.. كانت .. كانت .. كانت .. كانت .. كانت .. كانت ..
+
+1004
+01:04:35,840 --> 01:04:40,860
+كانت .. كانت .. كانت .. كانت .. كانت .. كانت ..
+
+1005
+01:04:40,860 --> 01:04:41,560
+كانت .. كانت .. كانت .. كانت .. كانت .. كانت ..
+
+1006
+01:04:41,560 --> 01:04:41,600
+كانت .. كانت .. كانت .. كانت .. كانت .. كانت ..
+
+1007
+01:04:41,600 --> 01:04:41,660
+كانت .. كانت .. كانت .. كانت .. كانت .. كانت ..
+
+1008
+01:04:41,660 --> 01:04:41,760
+كانت .. كانت .. كانت .. كانت .. كانت .. كانت ..
+
+1009
+01:04:41,760 --> 01:04:42,000
+كانت .. كانت .. كانت .. كانت .. كانت .. كانت ..
+
+1010
+01:04:42,000 --> 01:04:42,000
+كانت .. كانت .. كانت .. كانت .. كانت .. كانت ..
+
+1011
+01:04:42,000 --> 01:04:42,000
+كانت .. كانت .. كانت .. كانت .. كانت .. كانت ..
+
+1012
+01:04:42,000 --> 01:04:42,000
+كانت .. كانت .. كانت .. كانت .. كانت .. كانت ..
+
+1013
+01:04:42,000 --> 01:04:50,620
+كانت .. كانت .. كانت .. كانت .. كانت .. كانت ..
+
+1014
+01:04:50,620 --> 01:04:58,020
+كانت
+
+1015
+01:04:58,020 --> 01:05:05,960
+.. كانو الوقت مع مجموعتهم الخاصة مع ال CBS والورنر
+
+1016
+01:05:05,960 --> 01:05:13,900
+بروز أصبحوا 4 أطفال CW ال CBS و الورنر بروز و ال 4
+
+1017
+01:05:13,900 --> 01:05:19,480
+أطفال ال 3 منهم مجموعة لتجمع .. لتجعل ال 5 ساعات
+
+1018
+01:05:19,480 --> 01:05:26,080
+تصبح 9 ساعات .. ال 4 .. ال 4 ساعات ..4 طفل على
+
+1019
+01:05:26,080 --> 01:05:33,860
+التلفاز و5 ساعة اضافية من شركة CBSCW تصبح 9 ساعة
+
+1020
+01:05:33,860 --> 01:05:41,320
+تقوم بتصوير التلفاز على التلفاز 4 طفل وCW تغيروا
+
+1021
+01:05:41,320 --> 01:05:48,400
+اسمهم لتصبح Tunzai بدأوا في أغسطس 2014 و2010
+
+1022
+01:05:56,800 --> 01:06:06,380
+مثلًا تحتوي على دورميه المحيط وكل شخص لديه روبوت
+
+1023
+01:06:06,380 --> 01:06:14,460
+لكل شخص ديناصور كينج و UGO 5D و UGO 6L و دراجون با
+
+1024
+01:06:15,860 --> 01:06:20,180
+وهذه المصطلحات التي تصنعها الشركة مثل شايتك،
+
+1025
+01:06:20,180 --> 01:06:24,860
+بوكيمون، وفيفا بناتا، الجميع يعرفها، خاصة فيفا
+
+1026
+01:06:24,860 --> 01:06:25,800
+بناتا و بوكيمون
+
+1027
+01:06:28,610 --> 01:06:35,130
+العامة الأساسية الـ UGO وانتجتها وانتجتها وانتجتها
+
+1028
+01:06:35,130 --> 01:06:39,970
+وانتجتها
+
+1029
+01:06:39,970 --> 01:06:41,530
+وانتجتها وانتجتها وانتجتها وانتجتها وانتجتها
+
+1030
+01:06:41,530 --> 01:06:41,530
+وانتجتها وانتجتها وانتجتها وانتجتها وانتجتها
+
+1031
+01:06:41,530 --> 01:06:41,590
+وانتجتها وانتجتها وانتجتها وانتجتها وانتجتها
+
+1032
+01:06:41,590 --> 01:06:41,830
+وانتجتها وانتجتها وانتجتها وانتجتها وانتجتها
+
+1033
+01:06:41,830 --> 01:06:42,050
+وانتجتها وانتجتها وانتجتها وانتجتها وانتجتها
+
+1034
+01:06:42,050 --> 01:06:46,770
+وانتجتها وانتجتها وانتجتها وانتجتها وانتجتها
+
+1035
+01:06:46,770 --> 01:06:51,450
+وانتجتها و
+
+1036
+01:06:52,180 --> 01:06:58,000
+وكانت الشركة تدخلت في اتفاق إيجابي مع شركات أخرى
+
+1037
+01:06:58,000 --> 01:07:01,780
+وكانت تدخلت في إتفاق إيجابي مع شركات أخرى وكانت
+
+1038
+01:07:01,780 --> 01:07:01,780
+تدخلت في إتفاق إيجابي مع شركات أخرى وكانت تدخلت في
+
+1039
+01:07:01,780 --> 01:07:02,740
+إتفاق إيجابي مع شركات أخرى وكانت تدخلت في إتفاق
+
+1040
+01:07:02,740 --> 01:07:04,000
+إيجابي مع شركات أخرى وكانت تدخلت في إتفاق إيجابي
+
+1041
+01:07:04,000 --> 01:07:06,600
+مع شركات أخرى وكانت تدخلت في إتفاق إيجابي مع شركات
+
+1042
+01:07:06,600 --> 01:07:11,920
+أخرى وكانت تدخلت في إتفاق إيجابي مع شركات أخرى
+
+1043
+01:07:11,920 --> 01:07:17,480
+وكانت تدخلت في إتفاقام TV Tokyo بإعطائه لأطفال
+
+1044
+01:07:17,480 --> 01:07:21,340
+يجمعوا حقيقات بدون أن يدفعوا حصة من هذه الحقيقات
+
+1045
+01:07:21,340 --> 01:07:29,440
+لـ TV Tokyo وهو ما يخطر اتفاقاتهم الأصلية الشركات
+
+1046
+01:07:29,440 --> 01:07:34,120
+يحاولون حوالي 5 مليون دولار في تدفعاتهم
+
+1047
+01:07:35,870 --> 01:07:40,870
+الاعتبارات الخاطئة والاعتبارات غير مواجهة بشأن إذا
+
+1048
+01:07:40,870 --> 01:07:48,610
+قامت الشركات بإنهاء شركة UGO من فوركتز لأنها لا
+
+1049
+01:07:48,610 --> 01:07:54,930
+تصنعها بعد الانتهاء فوركتز قامت بالتحديد 11 تحديد
+
+1050
+01:07:54,930 --> 01:08:04,110
+الانفجار في 6 أبريل 2011 فوركتز طلبت من الحكومة أن
+
+1051
+01:08:04,110 --> 01:08:04,470
+تستخدم
+
+1052
+01:08:15,810 --> 01:08:20,950
+الشركة الوطنية اساتسو دي كيز هو شركة وطنية
+
+1053
+01:08:20,950 --> 01:08:28,570
+اليابانية تحاول تحكي تحكم الـ UGO فرنشيزية كل
+
+1054
+01:08:28,570 --> 01:08:33,610
+فرنشيزية حقوقية لتجعلها حقوقية في الولايات المتحدة
+
+1055
+01:08:35,140 --> 01:08:40,100
+وخصوصًا بالنسبة لسائق حقوق في السيريز الانمي
+
+1056
+01:08:40,100 --> 01:08:46,580
+الأخير عامًا زيكسال هو الانمي الأخير وكان يستمر في
+
+1057
+01:08:46,580 --> 01:08:49,920
+موضوع الفرنشيز الانتقالية التي كانت بسبب الواجهة
+
+1058
+01:08:49,920 --> 01:08:56,820
+في مجلس الانتقال الأمريكي الانتقالي على 14 يوليو
+
+1059
+01:08:58,630 --> 01:09:04,090
+الشركة .. الشرطة اتخذت .. اتخذت .. اتخذت اتخذت
+
+1060
+01:09:04,090 --> 01:09:12,130
+اتخذت اتخذت اتخذت اتخذت اتخذت اتخذت اتخذت اتخذت
+
+1061
+01:09:12,130 --> 01:09:15,090
+اتخذت اتخذت اتخذت اتخزت اتخزت اتخزت اتخزت اتخزت
+
+1062
+01:09:15,090 --> 01:09:15,990
+اتخزت اتخزت اتخزت اتخزت اتخزت اتخزت اتخزت اتخزت
+
+1063
+01:09:15,990 --> 01:09:15,990
+اتخزت اتخزت اتخزت اتخزت اتخزت اتخزت اتخزت اتخزت
+
+1064
+01:09:15,990 --> 01:09:24,160
+اتخزت اتخزت اتخزت اتخزت اتخزت اتخزت اتخوهو إذا
+
+1065
+01:09:24,160 --> 01:09:30,140
+كانت مجموعة ومجموعة صحيحة، وإذا كانت الشركة يجب أن
+
+1066
+01:09:30,140 --> 01:09:35,480
+تدفع كل شيء لدفعها لدفع شركة TV Tokyo، الشركة
+
+1067
+01:09:35,480 --> 01:09:45,330
+الأصلية، وفترة أولى بدأت في هذا العام، في أغسطسبنك
+
+1068
+01:09:45,330 --> 01:09:50,490
+فلسطين بنك فلسطين هو أول و أكبر بنك أمريكي وكان
+
+1069
+01:09:50,490 --> 01:09:55,770
+مؤسسا في 1960 وبدأت عملية عملية عملية عملية عملية
+
+1070
+01:09:55,770 --> 01:09:56,450
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+1071
+01:09:56,450 --> 01:09:56,650
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+1072
+01:09:56,650 --> 01:09:57,510
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+1073
+01:09:57,510 --> 01:09:57,510
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+1074
+01:09:57,510 --> 01:09:57,790
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+1075
+01:09:57,790 --> 01:10:01,170
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+1076
+01:10:01,170 --> 01:10:10,610
+عملية عملية عملية عملية عملية عملية عملية
+
+1077
+01:10:10,610 --> 01:10:17,630
+عبنك فلسطين هو أكثر مهمة في فلسطين من خلال نتوارك
+
+1078
+01:10:17,630 --> 01:10:25,750
+البنك يتجاوز من 45 قطع وقطع أخرى من جنين إلى رفح
+
+1079
+01:10:25,750 --> 01:10:32,290
+وصحبتها البنك فلسطين لديه عمليات ممتازة وموظفين
+
+1080
+01:10:32,290 --> 01:10:37,350
+عالميا في البنك لديه أكتر من ألف شخص
+
+1081
+01:10:41,620 --> 01:10:45,320
+توفر العديد من المساعدات التحقيقية التي تتجاوز
+
+1082
+01:10:45,320 --> 01:10:49,960
+احتجاز المستخدم والتوقع تحتوي على مصادر وشركات
+
+1083
+01:10:49,960 --> 01:10:55,260
+وشركات وشركات وشركات وشركات وشركات وشركات وشركات
+
+1084
+01:10:55,260 --> 01:10:55,420
+وشركات وشركات وشركات وشركات وشركات وشركات وشركات
+
+1085
+01:10:55,420 --> 01:10:55,420
+وشركات وشركات وشركات وشركات وشركات وشركات وشركات
+
+1086
+01:10:55,420 --> 01:10:55,720
+وشركات وشركات وشركات وشركات وشركات وشركات وشركات
+
+1087
+01:10:55,720 --> 01:10:57,420
+وشركات وشركات وشركات وشركات وشركات وشركات وشركات
+
+1088
+01:10:57,420 --> 01:11:05,700
+وشركات وشركات وشركات وشركات وشركات وشركات وشركات
+
+1089
+01:11:05,700 --> 01:11:13,430
+وشركات وشركاتالبنك الفلسطيني عرضت هذه السنة جوال
+
+1090
+01:11:13,430 --> 01:11:20,990
+في جوبيلي على موقع .. جوبيلي على موقع مرحلة 50 سنة
+
+1091
+01:11:20,990 --> 01:11:26,910
+من مؤسسته تحت السلوكان 50 سنة من بناء البنك تم
+
+1092
+01:11:26,910 --> 01:11:33,510
+تسمح بالمحافظة الفلسطينية في عام 2005 كمحافظة عام
+
+1093
+01:11:33,510 --> 01:11:41,000
+2006بنك فلسطين قامت ببناء شركة الوساطة لأستخدام
+
+1094
+01:11:41,000 --> 01:11:42,860
+الحماية الوساطة الوساطة الوساطة الوساطة الوساطة
+
+1095
+01:11:42,860 --> 01:11:43,360
+الوساطة الوساطة الوساطة الوساطة الوساطة الوساطة
+
+1096
+01:11:43,360 --> 01:11:44,520
+الوساطة الوساطة الوساطة الوساطة الوساطة الوساطة
+
+1097
+01:11:44,520 --> 01:11:47,180
+الوساطة الوساطة
+
+1098
+01:11:48,710 --> 01:11:55,770
+في فترة قصيرة، تصبح الشركة الأولى للإزالة،
+
+1099
+01:11:55,770 --> 01:12:01,010
+فإن رقم المحافظات افتتحت، والثالثة بالنسبة للتداول
+
+1100
+01:12:01,010 --> 01:12:05,930
+بين ال 10 شركات التجارب الموجودة في بلستين
+
+1101
+01:12:10,480 --> 01:12:16,040
+مليون يو اس دولار 120 مليون يو اس دولار قبلت
+
+1102
+01:12:16,040 --> 01:12:21,480
+كبيتال بعد تقليل 20 مليون يو اس دولار من المال
+
+1103
+01:12:21,480 --> 01:12:25,080
+الخاص بالمحافظة في ميو 2011
+
+1104
+01:12:28,160 --> 01:12:30,640
+البنك لديه اكتشاف اكتشاف أكتشاف أكتشاف أكتشاف
+
+1105
+01:12:30,640 --> 01:12:32,520
+أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف
+
+1106
+01:12:32,520 --> 01:12:36,720
+أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف
+
+1107
+01:12:36,720 --> 01:12:42,220
+أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف
+
+1108
+01:12:42,220 --> 01:12:45,660
+أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف
+
+1109
+01:12:45,660 --> 01:12:45,740
+أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف أكتشاف
+
+1110
+01:12:45,740 --> 01:12:52,820
+أكتشاف أكتشاف أكتشاف
+
+1111
+01:12:52,820 --> 01:12:59,820
+أكأسعار التحديات البلستانية يظهر بأن بنك البلستاني
+
+1112
+01:12:59,820 --> 01:13:06,860
+بدأ التجارب في نوفمبر 2005 أعلى السعر كان 6.75
+
+1113
+01:13:06,860 --> 01:13:15,220
+دولار الأمريكي في 2005 وهو مجموعة وإضافة في أسعار
+
+1114
+01:13:15,220 --> 01:13:16,460
+التحديات البلستانية
+
+1115
+01:13:24,170 --> 01:13:30,790
+2.5 دولار الأمريكي 2.5 دولار الأمريكي It was most
+
+1116
+01:13:30,790 --> 01:13:35,650
+volatile in 2007 with the difference between the
+
+1117
+01:13:35,650 --> 01:13:41,570
+annual low and high prices reaching 3.54 US dollar
+
+1118
+01:13:41,570 --> 01:13:51,750
+and nowadaysأنا أرى في الوصفة الوساطة الوصفة
+
+1119
+01:13:51,750 --> 01:13:54,690
+الوساطة الوصفة الوصفة الوصفة الوصفة الوصفة الوصفة
+
+1120
+01:13:54,690 --> 01:13:54,690
+الوصفة الوصفة الوصفة الوصفة الوصفة الوصفة الوصفة
+
+1121
+01:13:54,690 --> 01:14:01,330
+الوصفة الوصفة الوصفة الوصفة الوصفة الوصفة الوصفة
+
+1122
+01:14:02,210 --> 01:14:09,190
+الوضع الاقتصادي تأثير على المصطلح والمصطلح قام
+
+1123
+01:14:09,190 --> 01:14:17,250
+بتجاربه 10 مليون دولار تقريبا
+
diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/Mg1ijK8ToZc_raw.json b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/Mg1ijK8ToZc_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..7d20835bf146bd1efe5b06f2abc1a0bd40df4578
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/Mg1ijK8ToZc_raw.json
@@ -0,0 +1 @@
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diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/PMSt3QPxbME.srt b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/PMSt3QPxbME.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b8745d07365b0e6fac113350a75c0ab88c8583ee
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/PMSt3QPxbME.srt
@@ -0,0 +1,2964 @@
+
+1
+00:00:09,440 --> 00:00:12,920
+Stellar agent, this is the traditional role where
+
+2
+00:00:12,920 --> 00:00:17,400
+the salesman represents a person or company on the
+
+3
+00:00:17,400 --> 00:00:21,700
+selling end of a deal. The second type, which is the
+
+4
+00:00:21,700 --> 00:00:25,260
+buyer broker or buyer brokerage, which is the
+
+5
+00:00:25,260 --> 00:00:29,110
+opposite of a sales broker. هذا المكان الذي يتم تصميمه
+
+6
+00:00:29,110 --> 00:00:32,630
+لِلْشرطة للشركات لتصميم الأشياء التي يتم تصميمها
+
+7
+00:00:32,630 --> 00:00:35,890
+للشركات. هذا هو الشيء الذي يتم تطبيقه أكثر في تجارب
+
+8
+00:00:35,890 --> 00:00:42,550
+كبيرة. حسناً، والآن سنتحدث عن الطريقة الثالثة وهي
+
+9
+00:00:42,550 --> 00:00:47,880
+الـ Disclosed Dual Agents. Okay, the disclosed dual
+
+10
+00:00:47,880 --> 00:00:52,080
+agents; dual means مزدوج, which means both
+
+11
+00:00:52,080 --> 00:00:55,380
+parties. This is where the salesman represents both
+
+12
+00:00:55,380 --> 00:01:00,620
+parties in the sales process and acts as a mediator
+
+13
+00:01:00,620 --> 00:01:04,640
+for the transaction. The role of the salesman here
+
+14
+00:01:04,640 --> 00:01:08,240
+is to oversee that both parties receive an honest
+
+15
+00:01:08,240 --> 00:01:12,680
+and fair deal and is responsible for both.  الرابع
+
+16
+00:01:12,680 --> 00:01:17,980
+هو Transaction Broker وهو عكس الوظيفة وهو الوضع
+
+17
+00:01:17,980 --> 00:01:22,280
+الذي يتعامل مع المجلد الذي يتعامل مع المجلد الذي
+
+18
+00:01:22,280 --> 00:01:24,340
+يتعامل مع المجلد الذي يتعامل مع المجلد الذي يتعامل
+
+19
+00:01:24,340 --> 00:01:24,400
+مع المجلد الذي يتعامل مع المجلد الذي يتعامل مع المجلد
+
+20
+00:01:24,400 --> 00:01:24,720
+الذي يتعامل مع المجلد الذي يتعامل مع المجلد الذي
+
+21
+00:01:24,720 --> 00:01:25,900
+يتعامل مع المجلد الذي يتعامل مع المجلد الذي يتعامل
+
+22
+00:01:25,900 --> 00:01:32,080
+مع المجلد الذي يتعامل مع المجلد الذي يتعامل مع
+
+23
+00:01:32,080 --> 00:01:36,160
+المجلد الذي
+
+24
+00:01:36,160 --> 00:01:39,860
+يتع
+
+25
+00:01:41,840 --> 00:01:45,040
+Sales outsourcing; outsourcing means it's from
+
+26
+00:01:45,040 --> 00:01:49,920
+an external entity. It involves direct branded
+
+27
+00:01:49,920 --> 00:01:52,500
+representation where the sales representatives are
+
+28
+00:01:52,500 --> 00:01:55,860
+recruited, hired, and managed by an external entity
+
+29
+00:01:55,860 --> 00:02:00,180
+but represent themselves as the brand
+
+30
+00:02:00,180 --> 00:02:03,960
+of the client and report all activities through their
+
+31
+00:02:03,960 --> 00:02:07,020
+own sales management channels back to the client.
+
+32
+00:02:07,020 --> 00:02:10,860
+It's akin to a virtual extension of the Salesforce.
+
+33
+00:02:14,320 --> 00:02:18,820
+Okay, here we have sales managers; qualified and
+
+34
+00:02:18,820 --> 00:02:22,160
+talented sales managers absolutely aimed to
+
+35
+00:02:22,160 --> 00:02:25,980
+implement various sales strategies and management
+
+36
+00:02:25,980 --> 00:02:31,320
+techniques in order to facilitate improved profit
+
+37
+00:02:31,320 --> 00:02:34,840
+and increase sales volumes. They are also
+
+38
+00:02:34,840 --> 00:02:37,600
+responsible for coordinating the sales and
+
+39
+00:02:37,600 --> 00:02:40,920
+marketing departments, as well as oversight
+
+40
+00:02:42,080 --> 00:02:46,040
+concerning the fair and honest execution of the
+
+41
+00:02:46,040 --> 00:02:51,440
+sales process by their agents. Okay, the final type
+
+42
+00:02:51,440 --> 00:02:56,720
+which is salesman. Okay, the primary function of a
+
+43
+00:02:56,720 --> 00:03:00,560
+professional salesperson is to generate and close leads.
+
+44
+00:03:00,560 --> 00:03:06,060
+Educated prospects' needs and satisfy wants of
+
+45
+00:03:06,060 --> 00:03:09,860
+consumers appropriately and therefore turn
+
+46
+00:03:09,860 --> 00:03:14,380
+prospective customers into actual ones. They can do
+
+47
+00:03:14,380 --> 00:03:17,480
+this by questioning, which is to understand a
+
+48
+00:03:17,480 --> 00:03:20,500
+customer's goals and requirements relevant to the
+
+49
+00:03:20,500 --> 00:03:27,090
+product, وإنشاء حلول قيمة بمشاركة المعلومات المطلوبة
+
+50
+00:03:27,090 --> 00:03:29,950
+للمعلومات المطلوبة للمعلومات المطلوبة للمعلومات
+
+51
+00:03:29,950 --> 00:03:30,270
+المطلوبة للمعلومات المطلوبة للمعلومات المطلوبة
+
+52
+00:03:30,270 --> 00:03:31,870
+للمعلومات المطلوبة للمعلومات المطلوبة للمعلومات
+
+53
+00:03:31,870 --> 00:03:31,910
+المطلوبة للمعلومات المطلوبة للمعلومات المطلوبة
+
+54
+00:03:31,910 --> 00:03:32,090
+للمعلومات المطلوبة للمعلومات المطلوبة للمعلومات
+
+55
+00:03:32,090 --> 00:03:32,190
+المطلوبة للمعلومات المطلوبة للمعلومات المطلوبة
+
+56
+00:03:32,190 --> 00:03:35,810
+للمعلومات
+
+57
+00:03:35,810 --> 00:03:42,880
+المطلوبة للمعلومات المطلوبة. Okay, now I will talk
+
+58
+00:03:42,880 --> 00:03:47,480
+about the benefits of sales agents. Okay, you can
+
+59
+00:03:47,480 --> 00:03:51,500
+reach your customers effectively by using a sales
+
+60
+00:03:51,500 --> 00:03:54,980
+agent. Instead of having to recruit, train, and
+
+61
+00:03:54,980 --> 00:03:58,300
+finance your own employees, you can use an outside
+
+62
+00:03:58,300 --> 00:04:01,640
+sales agency. A good sales agent should already
+
+63
+00:04:01,640 --> 00:04:06,920
+have the necessary contacts and skills.  الافادات من
+
+64
+00:04:06,920 --> 00:04:09,620
+مؤسسات التسويق هي أن تستخدم مؤسسات التسويق لبناء
+
+65
+00:04:09,620 --> 00:04:10,960
+تسويق بدون عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+66
+00:04:10,960 --> 00:04:12,040
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+67
+00:04:12,040 --> 00:04:14,320
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+68
+00:04:14,320 --> 00:04:14,560
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+69
+00:04:14,560 --> 00:04:14,600
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+70
+00:04:14,600 --> 00:04:15,280
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+71
+00:04:15,280 --> 00:04:24,140
+عمل عمل عمل عمل عمل عمل عمل
+
+72
+00:04:24,140 --> 00:04:34,800
+ع
+
+73
+00:04:34,880 --> 00:04:44,160
+it takes you time, as
+
+74
+00:04:44,160 --> 00:04:48,020
+you
+
+75
+00:04:48,020 --> 00:04:49,700
+can see that next week we're going to have two
+
+76
+00:04:49,700 --> 00:04:53,140
+students, so that's next week. Did you present
+
+77
+00:04:53,140 --> 00:04:59,420
+anything before? The first time? Okay, okay. One of
+
+78
+00:04:59,420 --> 00:05:03,340
+you, you can choose. You're going to next week. عند
+
+79
+00:05:03,340 --> 00:05:07,740
+المناقشة، يمكنك اختيار أي شخص سيقوم
+
+80
+00:05:07,740 --> 00:05:12,700
+بِالمقالة. المقالة المقالة المقالة المقالة المقالة المقالة
+
+81
+00:05:12,700 --> 00:05:15,160
+المقالة المقالة المقالة المقالة المقالة المقالة
+
+82
+00:05:15,160 --> 00:05:15,580
+المقالة المقالة المقالة المقالة المقالة المقالة
+
+83
+00:05:15,580 --> 00:05:19,040
+المقالة المقالة المقالة المقالة المقالة المقالة
+
+84
+00:05:19,040 --> 00:05:23,320
+المقالة المقالة المقالة المقالة المقالة المقالة
+
+85
+00:05:23,320 --> 00:05:23,340
+المقالة المقالة المقالة المقالة المقالة المقالة
+
+86
+00:05:23,340 --> 00:05:30,000
+المقالة المقالة المقالة المقالة المقالة المقالة
+
+87
+00:05:31,320 --> 00:05:34,960
+complete what we have in agency. So next week we
+
+88
+00:05:34,960 --> 00:05:38,180
+will start with chapter 4. Next week with chapter 4.
+
+89
+00:05:38,180 --> 00:05:42,780
+According to me, what we have is to complete agency
+
+90
+00:05:42,780 --> 00:05:46,500
+chapter, then we will have an open discussion
+
+91
+00:05:46,500 --> 00:05:50,120
+about what we have left in this chapter and other
+
+92
+00:05:50,120 --> 00:05:53,240
+chapters, like, you know, for the past few weeks, four
+
+93
+00:05:53,240 --> 00:05:57,360
+weeks now, we have to evaluate what we had. تقول
+
+94
+00:05:57,360 --> 00:05:59,980
+Listen to... what's your name? عنود... listen to
+
+95
+00:05:59,980 --> 00:06:04,060
+عنود, and then you can ask. Hello everybody, I want to
+
+96
+00:06:04,060 --> 00:06:07,600
+talk today about franchising. I think that all
+
+97
+00:06:07,600 --> 00:06:12,620
+of you know about franchising. I want to talk
+
+98
+00:06:12,620 --> 00:06:15,720
+about it today. Franchising... franchising is a
+
+99
+00:06:15,720 --> 00:06:18,640
+contract between two independent parties that are
+
+100
+00:06:18,640 --> 00:06:22,860
+legally and economically independent, and
+
+101
+00:06:22,860 --> 00:06:25,420
+because of that, one of the parties, who is the
+
+102
+00:06:25,420 --> 00:06:28,870
+franchisor, يعطي الشركات الأخرى للمستخدمين
+
+103
+00:06:28,870 --> 00:06:29,730
+للمستخدمين المستخدمين المستخدمين المستخدمين
+
+104
+00:06:29,730 --> 00:06:31,070
+للمستخدمين المستخدمين المستخدمين المستخدمين
+
+105
+00:06:31,070 --> 00:06:33,250
+للمستخدمين المستخدمين المستخدمين المستخدمين
+
+106
+00:06:33,250 --> 00:06:36,150
+للمستخدمين المستخدمين المستخدمين المستخدمين
+
+107
+00:06:36,150 --> 00:06:37,450
+للمستخدمين المستخدمين المستخدمين المستخدمين
+
+108
+00:06:37,450 --> 00:06:38,470
+للمستخدمين المستخدمين المستخدمين المستخدمين
+
+109
+00:06:38,470 --> 00:06:39,010
+للمستخدمين المستخدمين المستخدمين المستخدمين
+
+110
+00:06:39,010 --> 00:06:45,270
+للمستخدمين المستخدمين المستخدمين المستخدمين
+
+111
+00:06:45,270 --> 00:06:50,290
+للمستخدمين
+
+112
+00:06:50,310 --> 00:06:57,050
+بالنسبة له أو هي، المدرسة، وعند تدريسه في موقع محدد
+
+113
+00:06:57,050 --> 00:07:01,450
+و منطقة جغرافية، منطقة
+
+114
+00:07:01,450 --> 00:07:05,650
+جغرافية محددة. له أو هي لإعطاء المساعدة التقنية
+
+115
+00:07:05,650 --> 00:07:10,210
+مع المساعدة التقنية، مع الحصول على إيجارات
+
+116
+00:07:10,210 --> 00:07:17,610
+مالية أو مصالحات، وانتصارات اقتصادية، نظرًا للتعامل مع
+
+117
+00:07:17,610 --> 00:07:25,510
+بعضهما البعض. المعنى franchising يمكن أن يكون مصمم من
+
+118
+00:07:25,510 --> 00:07:31,870
+الكثير من التصريحات. الأولى يمكننا أن نقول عنها هي
+
+119
+00:07:31,870 --> 00:07:39,430
+عملية استخدام ممارسة أخرى مشهورة. ممارسة مشهورة ممارسة
+
+120
+00:07:39,430 --> 00:07:42,770
+مشهورة ممارسة مشهورة ممارسة مشهورة ممارسة مشهورة
+
+121
+00:07:42,770 --> 00:07:43,670
+ممارسة مشهورة ممارسة مشهورة ممارسة مشهورة ممارسة
+
+122
+00:07:43,670 --> 00:07:47,030
+مشهورة ممارسة مشهورة ممارسة مشهورة ممارسة مشهورة
+
+123
+00:07:47,030 --> 00:07:48,170
+ممارسة مشهورة ممارسة مشهورة مشهورة مشهورة مشهورة
+
+124
+00:07:48,170 --> 00:07:49,250
+مشهورة مشهورة مشهورة مشهورة مشهورة مشهورة مشهورة
+
+125
+00:07:49,250 --> 00:07:52,040
+مشهورة مشهورة مشهورة مشهورة. هناك P.S. ليس هناك
+
+126
+00:07:52,040 --> 00:07:55,540
+قانون محدد يعتبر الـ franchising نفسه. نفسه نفسه
+
+127
+00:07:55,540 --> 00:08:13,040
+نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه
+
+128
+00:08:13,200 --> 00:08:16,440
+trust and credibility; expectation about the future
+
+129
+00:08:16,440 --> 00:08:22,300
+about this relationship; communication; all
+
+130
+00:08:22,300 --> 00:08:25,760
+the parties of the franchising must have well-
+
+131
+00:08:25,760 --> 00:08:28,940
+developed skills about interacting with each other, and
+
+132
+00:08:28,940 --> 00:08:33,600
+perceptions. There are types of franchising;
+
+133
+00:08:33,800 --> 00:08:36,600
+there are five types; five different types of
+
+134
+00:08:36,600 --> 00:08:39,880
+franchising: single-unit franchising is the
+
+135
+00:08:39,880 --> 00:08:43,520
+most similar and the most famous one. The second one is
+
+136
+00:08:43,520 --> 00:08:47,040
+sequential franchising; it's an alternative type
+
+137
+00:08:47,040 --> 00:08:50,140
+of franchising arrangement. Can you explain it;
+
+138
+00:08:50,820 --> 00:08:53,360
+what do you mean by single and sequential?
+
+139
+00:08:57,730 --> 00:09:03,790
+الثالث هو التطوير المنطقي. التطوير المنطقي هو تغيير
+
+140
+00:09:03,790 --> 00:09:07,710
+التجارب. التجارب التجارب التجارب التجارب التجارب التجارب
+
+141
+00:09:07,710 --> 00:09:09,630
+التجارب التجارب التجارب التجارب التجارب التجارب
+
+142
+00:09:09,630 --> 00:09:12,590
+التجارب التجارب التجارب التجارب التجارب التجارب
+
+143
+00:09:12,590 --> 00:09:26,430
+التجارب
+
+144
+00:09:27,380 --> 00:09:32,220
+في أمريكا، واشنطن. ممكن أسألك: هل لديك مثال عن الـ
+
+145
+00:09:32,220 --> 00:09:34,060
+franchising؟
+
+146
+00:09:35,420 --> 00:09:40,160
+Yes, when there is a successful business
+
+147
+00:09:40,160 --> 00:09:43,360
+organization that has specific and successful
+
+148
+00:09:43,360 --> 00:09:49,280
+management strategies, some new organizations want
+
+149
+00:09:49,280 --> 00:09:55,720
+to take these strategies. They can get these strategies
+
+150
+00:09:55,720 --> 00:10:00,500
+by franchising from the... Do you have any names
+
+151
+00:10:00,500 --> 00:10:01,160
+for any companies?
+
+152
+00:10:08,880 --> 00:10:14,060
+Okay, we are coming
+
+153
+00:10:14,060 --> 00:10:19,320
+back to the same chapter we had started with.
+
+154
+00:10:55,830 --> 00:11:00,850
+لذلك لم ننتهِ بعد من هذه الحلقة عن الوظيفة، كما ترى،
+
+155
+00:11:00,850 --> 00:11:06,350
+لدينا ثلاث نقاط مهمة لننظر إليها. الأولى كانت
+
+156
+00:11:06,350 --> 00:11:11,070
+الوظيفة التي كانت مُمََنَّعَة. الوظيفة التي كانت مُمََنَّعَة
+
+157
+00:11:11,070 --> 00:11:13,530
+الوظيفة التي كانت مُمََنَّعَة. الوظيفة التي كانت مُمََنَّعَة
+
+158
+00:11:13,530 --> 00:11:17,310
+الوظيفة التي كانت مُمََنَّعَة. الوظيفة التي كانت مُمََنَّعَة
+
+159
+00:11:17,310 --> 00:11:19,410
+الوظيفة التي كانت مُمََنَّعَة. الوظيفة التي كانت مُمََنَّعَة
+
+160
+00:11:19,410 --> 00:11:20,350
+الوظيفة التي كانت مُمََنَّعَة. الوظيفة التي كانت مُمََنَّعَة
+
+161
+00:11:20,350 --> 00:11:21,150
+الوظيفة التي كانت مُمََنَّعَة. الوظيفة التي كانت مُمََنَّعَة
+
+162
+00:11:21,150 --> 00:11:25,240
+لقد نظرنا في المرة الأخرى إلى Authority وكيفية
+
+163
+00:11:25,240 --> 00:11:30,000
+الوظيفة الواقعية والواضحة. والوظيفة والوظيفة والـ
+
+164
+00:11:30,000 --> 00:11:33,840
+الوظيفة والوظيفة والوظيفة والوظيفة والوظيفة والـ
+
+165
+00:11:33,840 --> 00:11:39,420
+الوظيفة والوظيفة والوظيفة والوظيفة والوظيفة والـ
+
+166
+00:11:39,420 --> 00:11:40,140
+الوظيفة والوظيفة والوظيفة والوظيفة والوظيفة والـ
+
+167
+00:11:40,140 --> 00:11:40,180
+الوظيفة والوظيفة والوظيفة والوظيفة والوظيفة والـ
+
+168
+00:11:40,180 --> 00:11:40,220
+الوظيفة والوظيفة والوظيفة والوظيفة والوظيفة والـ
+
+169
+00:11:40,220 --> 00:11:44,820
+الوظيفة والوظيفة والوظيفة والوظيفة والوظيفة والـ
+
+170
+00:11:44,820 --> 00:11:49,320
+كلاهما عملية مجلس ورئيس. قبل هذا... هل لازَم
+
+171
+00:11:49,320 --> 00:11:54,040
+لديك أسئلة في عقلك عن ما سبق، أم نستطيع أن
+
+172
+00:11:54,040 --> 00:11:54,700
+نكمل؟ نستطيع أن نستطيع أن نستطيع أن نستطيع أن
+
+173
+00:11:54,700 --> 00:11:54,860
+نستطيع أن نستطيع أن نستطيع أن نستطيع أن نستطيع أن
+
+174
+00:11:54,860 --> 00:11:56,540
+نستطيع أن نستطيع أن نستطيع أن نستطيع أن نستطيع أن
+
+175
+00:11:56,540 --> 00:11:56,700
+نستطيع أن نستطيع أن نستطيع أن نستطيع أن نستطيع أن
+
+176
+00:11:56,700 --> 00:11:57,040
+نستطيع أن نستطيع أن نستطيع أن نستطيع أن نستطيع أن
+
+177
+00:11:57,040 --> 00:11:57,980
+نستطيع أن نستطيع أن نستطيع أن نستطيع أن نستطيع أن
+
+178
+00:11:57,980 --> 00:12:02,040
+نستطيع أن نستطيع
+
+179
+00:12:02,040 --> 00:12:11,220
+أن نستطيع أن نستطيع أن نستطيع. agency; one of the
+
+180
+00:12:11,220 --> 00:12:14,760
+easiest chapters to study and one of the most
+
+181
+00:12:14,760 --> 00:12:18,280
+practical subjects in business law and commercial
+
+182
+00:12:18,280 --> 00:12:22,160
+law. I want to ask: does the agent can work for
+
+183
+00:12:22,160 --> 00:12:27,010
+many principals? وهو سؤال جيد، يجب أن نجيب على هذا
+
+184
+00:12:27,010 --> 00:12:30,590
+السؤال اليوم. هذا واحد من الأشياء التي يجب أن ننظر
+
+185
+00:12:30,590 --> 00:12:36,430
+إليها ونقررها. الواقعية، الواقعية، الأشياء... كم عدد
+
+186
+00:12:36,430 --> 00:12:40,350
+الوظائف التي يمكن أن تعمل على واحد أو اثنين أو ربما
+
+187
+00:12:40,350 --> 00:12:4
+
+223
+00:15:08,800 --> 00:15:13,180
+دفعات ماهي دفعات ماهي دفعة ماهي دفعة ماهي دفعة
+
+224
+00:15:13,180 --> 00:15:15,900
+ماهي دفعة ماهي دفعة ماهي دفعة ماهي دفعة ماهي دفعة
+
+225
+00:15:15,900 --> 00:15:15,920
+ماهي دفعة ماهي دفعة ماهي دفعة ماهي دفعة ماهي دفعة
+
+226
+00:15:15,920 --> 00:15:16,360
+ماهي دفعة ماهي دفعة ماهي دفعة ماهي دفعة ماهي دفعة
+
+227
+00:15:16,360 --> 00:15:21,220
+ماهي دفعة ماهي دفعة ماهي دفعة ماهي دفعة ماهي دفعة
+
+228
+00:15:21,220 --> 00:15:24,820
+ماهي دفعة
+
+229
+00:15:24,820 --> 00:15:31,130
+ماهي دفعة ماهي دفعة إذا أعطيت شخص من خلالك أن يكون
+
+230
+00:15:31,130 --> 00:15:36,330
+عمليًا ليعمل شيء لأجلي، فسأعطي كل المعلومات
+
+231
+00:15:36,330 --> 00:15:40,970
+المحتاجة للشخص، وسأتوقع أنه أو أنها ستعمل كل
+
+232
+00:15:40,970 --> 00:15:44,210
+الاختيارات المحتاجة لإكمال التعامل مع المستخدمين،
+
+233
+00:15:44,210 --> 00:15:48,250
+وفي نفس الوقت، إذا كان العملي يدفع بعض المال في
+
+234
+00:15:48,250 --> 00:15:54,320
+المدرسة إذا كان مجلدي يدفع بعض المال وكان هذا المال
+
+235
+00:15:54,320 --> 00:15:57,720
+محتاجًا لإنهاء اتفاق مع الشركة الثالثة، فأنا
+
+236
+00:15:57,720 --> 00:16:02,040
+سأجعله يدفع بعض المال إذا أعطى مجلدي أن يدفع بعض
+
+237
+00:16:02,040 --> 00:16:08,140
+المال، فأنا سأدفعه بعض المال. And if he or she feels
+
+238
+00:16:08,140 --> 00:16:10,960
+that it was really necessary and important that
+
+239
+00:16:10,960 --> 00:16:13,980
+they would have to pay some money for my business.
+
+240
+00:16:13,980 --> 00:16:17,040
+You pay some money for my business as my agent, and
+
+241
+00:16:17,040 --> 00:16:20,040
+that was really necessary for my business, then I
+
+242
+00:16:20,040 --> 00:16:22,260
+would not say no. I would have to compensate you.
+
+243
+00:16:22,260 --> 00:16:27,340
+Call it indemnify, indemnify payments; that's called
+
+244
+00:16:27,340 --> 00:16:31,040
+liability, liability. What we have today here, it's
+
+245
+00:16:31,040 --> 00:16:36,030
+not liability; it's called duty. The money I would
+
+246
+00:16:36,030 --> 00:16:38,770
+have to pay you as an agent for what you did for
+
+247
+00:16:38,770 --> 00:16:42,290
+me; what you did was a job. You work for me as an
+
+248
+00:16:42,290 --> 00:16:45,590
+agent. I pay you money as a commission, and this
+
+249
+00:16:45,590 --> 00:16:48,410
+money, commission, for what you done for one week,
+
+250
+00:16:48,410 --> 00:16:51,510
+for one month, for two years; it's equal to a
+
+251
+00:16:51,510 --> 00:16:54,410
+payment which is called salary. It's like a salary,
+
+252
+00:16:54,410 --> 00:16:58,350
+but it's called, here it's called commission or
+
+253
+00:16:58,350 --> 00:17:02,190
+reasonable fee established after the fact.
+
+254
+00:17:02,190 --> 00:17:08,900
+Commission here. ألفى لكى A prearranged, if something
+
+255
+00:17:08,900 --> 00:17:12,040
+was accepted, was arranged between agent and a
+
+256
+00:17:12,040 --> 00:17:14,900
+principal, like say paying you a thousand dollar a
+
+257
+00:17:14,900 --> 00:17:18,800
+month; that's arrangement, we have done it already.
+
+258
+00:17:18,800 --> 00:17:22,740
+Sometimes, if we don't have an agreement between
+
+259
+00:17:22,740 --> 00:17:26,520
+the agent and a principal, then we would have a
+
+260
+00:17:26,520 --> 00:17:29,350
+reasonable fee. عامة عامة عامة عامة عامة عامة عامة
+
+261
+00:17:29,350 --> 00:17:33,870
+عامة عامة عامة عامة عامة
+
+262
+00:17:33,870 --> 00:17:34,530
+عامة عامة عامة عامة عامة عامة عامة عامة عامة
+
+263
+00:17:34,530 --> 00:17:40,170
+عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة
+
+264
+00:17:40,170 --> 00:17:42,190
+عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة
+
+265
+00:17:42,190 --> 00:17:43,130
+عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة
+
+266
+00:17:43,130 --> 00:17:46,570
+عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة
+
+267
+00:17:46,570 --> 00:17:57,430
+عامة عامة
+
+268
+00:17:57,430 --> 00:18:00,860
+ثم إذا كان لدينا هذه المقارنة، فسننظر إلى المال
+
+269
+00:18:00,860 --> 00:18:08,020
+المناسب، شيء جيد للشخص، شيء مناسب لما كان يفعله
+
+270
+00:18:08,020 --> 00:18:11,860
+لي، سننظر إلى السوق، كم يمكن أن يحصل. مصاريف مصاريف
+
+271
+00:18:11,860 --> 00:18:15,140
+مصاريف مصاريف مصاريف مصاريف مصاريف مصاريف مصاريف مصاريف
+
+272
+00:18:15,140 --> 00:18:15,560
+مصاريف مصاريف مصاريف مصاريف مصاريف مصاريف مصاريف مصاريف
+
+273
+00:18:15,560 --> 00:18:16,040
+مصاريف مصاريف مصاريف مصاريف مصاريف مصاريف مصاريف مصاريف
+
+274
+00:18:16,040 --> 00:18:18,260
+مصاريف مصاريف مصاريف مصاريف مصاريف مصاريف 1500 دولار، 2000
+
+275
+00:18:18,260 --> 00:18:24,440
+دولار، ويمكننا أن ننظر إلى المال المناسب، ويمكننا
+
+276
+00:18:24,440 --> 00:18:24,540
+أن ننظر إلى المال المناسب، و يمكننا أن ننظر إلى
+
+277
+00:18:24,540 --> 00:18:24,760
+المال المناسب، و يمكننا أن ننظر إلى المال المناسب، و
+
+278
+00:18:24,760 --> 00:18:25,580
+يمكننا أن ننظر إلى المال المناسب، و يمكننا أن ننظر
+
+279
+00:18:25,580 --> 00:18:25,740
+إلى المال المناسب، و يمكننا أن ننظر إلى المال
+
+280
+00:18:25,740 --> 00:18:27,260
+المناسب، و يمكننا أن ننظر إلى المال المناسب، و
+
+281
+00:18:27,260 --> 00:18:27,280
+المناسب، و يمكننا أن ننظر إلى المال المناسب، و
+
+282
+00:18:27,280 --> 00:18:27,540
+يمكننا أن ننظر إلى المال المناسب، و يمكننا أن ننظر
+
+283
+00:18:27,540 --> 00:18:40,700
+إلى المال المناسب، و
+
+284
+00:18:40,700 --> 00:18:47,070
+يمكننا أن... الثاني عمل، أو عمل. مجرد مجرد مجرد مجرد
+
+285
+00:18:47,070 --> 00:18:53,650
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+286
+00:18:53,650 --> 00:18:54,030
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+287
+00:18:54,030 --> 00:18:54,110
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+288
+00:18:54,110 --> 00:18:54,190
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+289
+00:18:54,190 --> 00:18:54,190
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+290
+00:18:54,190 --> 00:19:01,310
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+291
+00:19:01,310 --> 00:19:07,270
+م
+
+292
+00:19:17,820 --> 00:19:20,620
+و ..
+
+293
+00:19:22,620 --> 00:19:27,220
+And my colleague said first... first, he must give
+
+294
+00:19:27,220 --> 00:19:30,120
+orders to the principal. Okay, he must follow...
+
+295
+00:19:30,120 --> 00:19:34,560
+follow the instructions and respect it and favor
+
+296
+00:19:34,560 --> 00:19:39,960
+it, and he shouldn't follow any new publication
+
+297
+00:19:39,960 --> 00:19:43,780
+which is inconsistent with his principles or by
+
+298
+00:19:43,780 --> 00:19:49,740
+the principal. He must... are able to...
+
+299
+00:19:52,930 --> 00:19:56,990
+ويجب أن نفهم أن المهندس يجب أن يقوم بالعمل كما
+
+300
+00:19:56,990 --> 00:20:00,940
+قلت في المهندسة. Appointing someone as an agent, he
+
+301
+00:20:00,940 --> 00:20:04,640
+or she would have information, instructions from
+
+302
+00:20:04,640 --> 00:20:07,040
+the principal, telling that person what to do.
+
+303
+00:20:07,040 --> 00:20:11,060
+That's my job as an agent. What shall I do? How much
+
+304
+00:20:11,060 --> 00:20:13,360
+transactions? How many transactions can I do? How
+
+305
+00:20:13,360 --> 00:20:16,520
+much money can I spend? All this question would be
+
+306
+00:20:16,520 --> 00:20:19,820
+in my mind. I will follow the instructions. I will
+
+307
+00:20:19,820 --> 00:20:25,940
+do my job as stated in the agency contract. In
+
+308
+00:20:25,940 --> 00:20:28,740
+addition to this, we have a main point, which is
+
+309
+00:20:28,740 --> 00:20:33,780
+loyalty; being honest, being loyal to the principal.
+
+310
+00:20:33,780 --> 00:20:36,660
+And I guess that for you, it's easy to understand
+
+311
+00:20:36,660 --> 00:20:40,240
+the meaning of loyalty. Someone is loyal; what does
+
+312
+00:20:40,240 --> 00:20:49,200
+it mean? Can anyone explain it? Loyalty. Okay.
+
+313
+00:21:13,090 --> 00:21:16,370
+Okay, loyalty includes many aspects, but one of the
+
+314
+00:21:16,370 --> 00:21:19,910
+main aspects here, not to accept new obligations.
+
+315
+00:21:21,520 --> 00:21:25,560
+What kind of obligations? Obligations that are
+
+316
+00:21:25,560 --> 00:21:29,020
+inconsistent with the main job. If they were
+
+317
+00:21:29,020 --> 00:21:32,620
+consistent, that's fine. I should not do any other
+
+318
+00:21:32,620 --> 00:21:36,640
+job which can be conflicted, which can conflict
+
+319
+00:21:36,640 --> 00:21:43,120
+with my main duties. Any agent who is working for
+
+320
+00:21:43,120 --> 00:21:48,100
+someone should do the job to his best. ولا يجب أن
+
+321
+00:21:48,100 --> 00:21:51,900
+نقبل وظيفة جديدة، ولا يجب أن نعمل لأكثر من واحد
+
+322
+00:21:51,900 --> 00:21:56,060
+عمل، إلا إذا كان لدينا بعض الوضوحات. فإذا اتبعت
+
+323
+00:21:56,060 --> 00:22:00,400
+هذه الوضوحات، فسيكون بخير، ولكن عامةً واحد لواحد
+
+324
+00:22:00,400 --> 00:22:05,460
+عمل، ليس وظيفة جديدة؛ إنها غير متوافقة مع
+
+325
+00:22:05,460 --> 00:22:11,060
+العمليات. هذا سيجعل عقلنا يسأل عن الممكنات.
+
+326
+00:22:14,310 --> 00:22:23,570
+هل يكون بخير أم لا؟ هل يمكننا أن نواجه موقف يعمل
+
+327
+00:22:23,570 --> 00:22:28,570
+مع شخص آخر ويعمل معي أم لا؟ هل هذا ممكن أم لا؟ هل
+
+328
+00:22:28,570 --> 00:22:32,430
+يمكنني أن احتفظ بموقفي؟ هل يمكنني أن أمنعه من
+
+329
+00:22:32,430 --> 00:22:36,270
+العمل مع شخص آخر إلا معي؟ هذه الأسئلة يجب أن ننظر
+
+330
+00:22:36,270 --> 00:22:42,620
+إليها، ونجيب عليها. ما رأيك هنا؟ Need someone else
+
+331
+00:22:42,620 --> 00:22:45,680
+like an agent. Can he work for somebody else except
+
+332
+00:22:45,680 --> 00:23:01,800
+for me? It's
+
+333
+00:23:01,800 --> 00:23:06,440
+possible. I mean, the general idea, it's fine. You
+
+334
+00:23:06,440 --> 00:23:08,880
+have the freedom to work for more than one
+
+335
+00:23:08,880 --> 00:23:11,940
+principal, but if you would like to do it, you have
+
+336
+00:23:11,940 --> 00:23:13,660
+to be careful; you have to follow the
+
+337
+00:23:13,660 --> 00:23:16,560
+instructions; you have to tell both. We have some
+
+338
+00:23:16,560 --> 00:23:18,760
+conditions; we have to follow those conditions.
+
+339
+00:23:18,760 --> 00:23:22,740
+Otherwise, we cannot make it. I cannot just be
+
+340
+00:23:22,740 --> 00:23:25,600
+working for two people at the same time, doing the
+
+341
+00:23:25,600 --> 00:23:28,560
+same job. This is what we call; it's called
+
+342
+00:23:28,560 --> 00:23:35,420
+inconsistent. مثل أن أنا ممكن أعمل في مكانين، وشركتين
+
+343
+00:23:35,420 --> 00:23:39,840
+في نفس الوقت، وهؤلاء الشركات يتنافسون. مثل أن
+
+344
+00:23:39,840 --> 00:23:44,380
+أنا ممكن أكون مستشار... ممكن أكون مستشار لشركة كمبيوتر
+
+345
+00:23:44,380 --> 00:23:50,370
+بي سي، سيلين بي سي، و LCD، وإلكترونيكس. أنا لا أستطيع
+
+346
+00:23:50,370 --> 00:23:53,050
+أن أعمل لدى هاتين الشركتين في نفس الوقت، في نفس العمل،
+
+347
+00:23:53,050 --> 00:23:56,670
+لأنني أستطيع أن أفهم منذ البداية أن تلك الشركات
+
+348
+00:23:56,670 --> 00:24:01,090
+تتنافس مع بعضها البعض. وإذا كنت سأعمل لديهم كلاهما، أو
+
+349
+00:24:01,090 --> 00:24:03,370
+كلاهما، أو كلاهما، أو كلاهما، أو كلاهما، أو كلاهما، أو كلاهما، أو
+
+350
+00:24:03,370 --> 00:24:04,570
+كلاهما، أو كلاهما، أو كلاهما، أو كلاهما، أو كلاهما، أو كلاهما، أنا
+
+351
+00:24:04,570 --> 00:24:09,010
+لن... في هذه الحالة، أحيانًا سأقوم بتحرير أو
+
+352
+00:24:09,010 --> 00:24:15,150
+تهيئة موقعي، وتهيئة موقعي، وموقعي، وموقعي، وموقعي
+
+353
+00:24:15,150 --> 00:24:17,710
+و موقعي، و موقعي، و موقعي، و موقعي، و موقعي، و موقعي، و
+
+354
+00:24:17,710 --> 00:24:18,350
+موقعي، و موقعي، و موقعي، و موقعي، و موقعي، و موقعي، و
+
+355
+00:24:18,350 --> 00:24:18,370
+موقعي، و موقعي، و موقعي، و موقعي، و موقعي، و موقعي، و
+
+356
+00:24:18,370 --> 00:24:18,650
+موقعي، و موقعي، و موقعي، و موقعي، و موقعي، و موقعي، و
+
+357
+00:24:18,650 --> 00:24:22,150
+موقعي، و موقعي، و موقعي، و موقعي، و موقعي، و موقعي، و
+
+358
+00:24:22,150 --> 00:24:31,510
+موقعي، و موقعي، و
+
+359
+00:24:31,510 --> 00:24:32,370
+موقع
+
+360
+00:24:55,620 --> 00:25:02,640
+Okay, that's fine.
+
+361
+00:25:02,640 --> 00:25:08,020
+Now, in fact، أشخاص يستطيعون أن يمثلوا أكثر من واحد
+
+362
+00:25:08,020 --> 00:25:11,100
+من المصطلح. هو أو هي يستطيعون ذلك. لديك الحرية
+
+363
+00:25:11,100 --> 00:25:16,140
+لِتَفعل ذلك مع تلك الوضعين. في الواقع، في الواقع، في
+
+364
+00:25:16,140 --> 00:25:19,760
+الواقع، في الواقع، في الواقع، في الواقع، في الواقع، في
+
+365
+00:25:19,760 --> 00:25:23,080
+الواقع، في الواقع، في الواقع.
+
+366
+00:25:24,250 --> 00:25:29,350
+حتى لو استطعت أن أفهم من البداية أن عملي مع
+
+367
+00:25:29,350 --> 00:25:33,390
+المصطلح الثاني سيتعارض مع عملي مع المصطلح الحالي.
+
+368
+00:25:33,390 --> 00:25:39,310
+في هذه الحالة، أفضل طريقة، أفضل حل، هو أن تُعلم كلا
+
+369
+00:25:39,310 --> 00:25:44,410
+الاثنين. كتابةً، كتابةً، كتابةً، كتابةً، كتابةً،
+
+370
+00:25:44,410 --> 00:25:51,220
+كتابةً، كتابةً. بِعَمَل هذا، أفعل أفضل ما أستطيع، وأعرف ما
+
+371
+00:25:51,220 --> 00:25:54,460
+أفعله.
+
+372
+00:25:54,460 --> 00:25:59,540
+وأعرف ما أفعله، و
+
+373
+00:25:59,540 --> 00:26:02,520
+أعرف ما أفعله، وأعرف ما أفعله، وأعرف ما أفعله، و
+
+374
+00:26:02,520 --> 00:26:04,660
+أعرف ما أفعله، وأعرف ما أفعله، وأعرف ما أفعله، و
+
+375
+00:26:04,660 --> 00:26:05,460
+أعرف ما أفعله، وأعرف ما أفعله، وأعرف ما أفعله، و
+
+376
+00:26:05,460 --> 00:26:05,480
+أعرف ما أفعله، وأعرف ما أفعله، وأعرف ما أفعله، و
+
+377
+00:26:05,480 --> 00:26:11,900
+أعرف ما أفعله، وأعرف ما أفعله، و
+
+378
+00:26:11,900 --> 00:26:15,190
+أعرف ما أفعله. Then I would have to tell both of them
+
+379
+00:26:15,190 --> 00:26:20,870
+on time what I'm doing, in details, in order to do
+
+380
+00:26:20,870 --> 00:26:25,150
+my job as stated in the contract between me and
+
+381
+00:26:25,150 --> 00:26:30,560
+the university. أي شخص يرغب في العمل في اتصال، اتصال، اتصال،
+
+382
+00:26:30,560 --> 00:26:39,060
+اتصال، اتصال، اتصال، اتصال، اتصال، اتصال، اتصال، اتصال،
+
+383
+00:26:39,060 --> 00:26:48,980
+اتصال، اتصال.
+
+384
+00:26:48,980 --> 00:26:56,720
+اتصال، اتصال، اتصال، اتصال.
+
+385
+00:26:56,720 --> 00:26:59,800
+اتصال، اتصال. المهم أن تكون مُستخدَمًا، ومُستخدَمًا بكل
+
+386
+00:26:59,800 --> 00:27:00,220
+المعلومات، وكل المعلومات، وكل المعلومات، وكل
+
+387
+00:27:00,220 --> 00:27:01,380
+المعلومات، وكل المعلومات، وكل المعلومات، وكل
+
+388
+00:27:01,380 --> 00:27:03,020
+المعلومات، وكل المعلومات، وكل المعلومات، وكل
+
+389
+00:27:03,020 --> 00:27:04,420
+المعلومات، وكل المعلومات، وكل المعلومات، وكل
+
+390
+00:27:04,420 --> 00:27:04,840
+المعلومات، وكل المعلومات، وكل المعلومات، وكل
+
+391
+00:27:04,840 --> 00:27:05,020
+المعلومات، وكل المعلومات، وكل المعلومات، وكل
+
+392
+00:27:05,020 --> 00:27:05,080
+المعلومات، وكل المعلومات، وكل المعلومات، وكل
+
+393
+00:27:05,080 --> 00:27:06,680
+المعلومات، وكل المعلومات، وكل المعلومات، وكل
+
+394
+00:27:06,680 --> 00:27:06,760
+المعلومات، وكل المعلومات، وكل المعلومات، وكل
+
+395
+00:27:06,760 --> 00:27:10,400
+المعلومات، وكل المعلومات، وكل المعلومات، وكل
+
+396
+00:27:10,400 --> 00:27:19,300
+المعلومات، و
+
+397
+00:27:19,300 --> 00:27:22,890
+كل المعلومات. You can do it with the first condition, and
+
+398
+00:27:22,890 --> 00:27:25,670
+in addition to this, you have to prevent any
+
+399
+00:27:25,670 --> 00:27:29,450
+situation; you have to stop any situation in which
+
+400
+00:27:29,450 --> 00:27:34,090
+my job as an agent, or your job as an agent, will
+
+401
+00:27:34,090 --> 00:27:3
+
+445
+00:30:33,990 --> 00:30:40,350
+المصطلح، فلو كان هناك شيء مُصطلح في مجلس الشركة
+
+446
+00:30:40,350 --> 00:30:47,850
+بينك كشركة ومُصطلح الشركة، فهذه النقطة مُصطلحة في
+
+447
+00:30:47,850 --> 00:30:53,660
+مجلس الشركة. إذا كانت أي عملية من هذه النقطة كانت
+
+448
+00:30:53,660 --> 00:30:59,440
+مقبلة وقَبِلة من نفسي كمسؤول وكمسؤول فهو بخير في
+
+449
+00:30:59,440 --> 00:31:01,780
+المستقبل. إذا كنت تريد أن تقوم بأي من هذه العملية
+
+450
+00:31:01,780 --> 00:31:11,270
+إذا قلت في مجلستي ومسؤوليتي أنني سأعمل لك كمسؤول. I
+
+451
+00:31:11,270 --> 00:31:16,130
+would be teaching for so and so companies. I would
+
+452
+00:31:16,130 --> 00:31:19,350
+be working as a consultant for other two companies
+
+453
+00:31:19,350 --> 00:31:22,690
+at the same time in the future. He or she as a
+
+454
+00:31:22,690 --> 00:31:26,030
+principal will not be able to come back to me, say
+
+455
+00:31:26,030 --> 00:31:28,310
+"Well, you should not do it," because in the same
+
+456
+00:31:28,310 --> 00:31:31,510
+contract of agency between principal and agent
+
+457
+00:31:31,510 --> 00:31:37,100
+this agency itself has stated. كل المهارات التي قد
+
+458
+00:31:37,100 --> 00:31:39,740
+تم إقناعها من كلا الجانبين. مهارة و رئيس مهارة
+
+459
+00:31:39,740 --> 00:31:45,120
+فالمهارة ستكون لديها الحرص في المستقبل لتعمل على
+
+460
+00:31:45,120 --> 00:31:50,440
+هذه المهارات دون أن تتحدث مع الرئيس، دون أن تسأله
+
+461
+00:31:50,440 --> 00:32:00,000
+عن اسمه. هذا كل شيء رقم واحد. عن المواجهة الأخرى هو:
+
+462
+00:32:03,090 --> 00:32:05,830
+هل تستطيع أن تجعل العميل يتعامل مع الشركات، أو
+
+463
+00:32:05,830 --> 00:32:09,450
+يتعامل مع الشركات، ويتعامل مع الشركات، ويتعامل مع
+
+464
+00:32:09,450 --> 00:32:10,270
+الشركات، ويتعامل مع الشركات، ويتعامل مع الشركات، و
+
+465
+00:32:10,270 --> 00:32:11,090
+يتعامل مع الشركات، ويتعامل مع الشركات، ويتعامل مع
+
+466
+00:32:11,090 --> 00:32:12,490
+الشركات، ويتعامل مع الشركات، ويتعامل مع الشركات، و
+
+467
+00:32:12,490 --> 00:32:14,470
+يتعامل مع الشركات، ويتعامل مع الشركات، ويتعامل مع
+
+468
+00:32:14,470 --> 00:32:14,950
+الشركات، ويتعامل مع الشركات، ويتعامل مع الشركات، و
+
+469
+00:32:14,950 --> 00:32:20,150
+يتعامل مع الشركات، ويتعامل مع الشركات، ويتعامل مع
+
+470
+00:32:20,150 --> 00:32:30,050
+الشركات، ويتعامل مع الشركات، ويتعامل مع الشركات، و
+
+471
+00:32:30,050 --> 00:32:34,910
+يستطيع استخدام المكان والموقع والعمل لتجارب
+
+472
+00:32:34,910 --> 00:32:41,210
+نفسه، وهذا غير مسموح. واحدة من عمليات الأسهم للشركة هي
+
+473
+00:32:41,210 --> 00:32:45,490
+أنها لا تقبل، أو لا تجعل...أنا آسف...لا تجعل نفسه
+
+474
+00:32:45,490 --> 00:32:52,990
+ناجحًا بشكل خاص أو خاطئًا. مثل ماذا؟ بعض الأشخاص يستخدمون
+
+475
+00:32:52,990 --> 00:32:56,570
+السيارة، أو السيارة، أو السيارة، أو السيارة، أو
+
+476
+00:32:56,570 --> 00:32:59,310
+السيارة، أو السيارة، أو السيارة، أو السيارة، أو
+
+477
+00:32:59,310 --> 00:33:00,530
+السيارة، أو السيارة، أو السيارة، أو السيارة، أو
+
+478
+00:33:00,530 --> 00:33:01,010
+السيارة، أو السيارة، أو السيارة، أو السيارة، أو
+
+479
+00:33:01,010 --> 00:33:01,810
+السيارة، أو السيارة، أو السيارة، أو السيارة، أو
+
+480
+00:33:01,810 --> 00:33:02,670
+السيارة، أو السيارة، أو السيارة، أو السيارة، أو
+
+481
+00:33:02,670 --> 00:33:09,030
+السيارة، أو السيارة، أو السيارة، أو السيارة، أو
+
+482
+00:33:09,030 --> 00:33:15,410
+السيارة، أو
+
+483
+00:33:15,410 --> 00:33:19,560
+السيارة. He or she as an agent is supposed only to sell in
+
+484
+00:33:19,560 --> 00:33:22,940
+this company, in this store, commodities, commodities
+
+485
+00:33:22,940 --> 00:33:25,640
+and items belonging to the principal. Some of them
+
+486
+00:33:25,640 --> 00:33:29,180
+what they do, they get some goods and items in the
+
+487
+00:33:29,180 --> 00:33:31,680
+same place and they sell them for the agent, for
+
+488
+00:33:31,680 --> 00:33:35,760
+himself. This is illegal; it's not allowed, and the
+
+489
+00:33:35,760 --> 00:33:38,460
+principal can sue the agent for this. He can sack
+
+490
+00:33:38,460 --> 00:33:41,810
+him. وهناك الكثير من الأمثلة من خلال هذا البرنامج.
+
+491
+00:33:41,810 --> 00:33:47,770
+أنا أعرف شركات هنا، وبعضهم...بعضهم كعامل يُمنحون
+
+492
+00:33:47,770 --> 00:33:51,230
+مكانًا للوظيفة. أنا أُقصد، حسناً، يمكنك استخدام السيارة.
+
+493
+00:33:51,230 --> 00:33:56,310
+يمكنك استخدام المكان، ولكن لـ so and so. هم هم هم هم
+
+494
+00:33:56,310 --> 00:33:57,030
+هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم
+
+495
+00:33:57,030 --> 00:33:58,250
+هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم
+
+496
+00:33:58,250 --> 00:33:58,350
+هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم
+
+497
+00:33:58,350 --> 00:34:06,950
+هم هم هم هم هم هم هم هم هم هم هم هم
+
+498
+00:34:06,950 --> 00:34:10,610
+هليس لإنجاز نفسي، وليس لإثراء بشكل صحيح، لإنجاز
+
+499
+00:34:10,610 --> 00:34:12,150
+نفسي، وليس لإثراء بشكل صحيح، لإثراء بشكل صحيح
+
+500
+00:34:12,150 --> 00:34:16,290
+لإثراء بشكل صحيح، لإثراء بشكل صحيح، لإثراء
+
+501
+00:34:16,290 --> 00:34:18,130
+بشكل صحيح، لإثراء بشكل صحيح، لإثراء بشكل صحيح
+
+502
+00:34:18,130 --> 00:34:20,270
+لإثراء بشكل صحيح، لإثراء بشكل صحيح، لإثراء
+
+503
+00:34:20,270 --> 00:34:25,790
+بشكل صحيح، لإثراء بشكل صحيح، لإثراء بشكل صحيح
+
+504
+00:34:25,790 --> 00:34:29,670
+لإثراء بشكل صحيح، لإيغ
+
+505
+00:34:35,470 --> 00:34:43,090
+عن كيف ننتهي، وكيف ننهي شركتي بسهولة أو صعوبة؟ إذا
+
+506
+00:34:43,090 --> 00:34:49,590
+كنت شركتي وكنت أرغب أن أنتهي، أو أن أُنهي شركتي، هل
+
+507
+00:34:49,590 --> 00:34:57,690
+أستطيع؟ بأي وقت؟ هل أنت متأكد؟ يتعامل مع الوظيفة؟
+
+508
+00:34:57,690 --> 00:35:03,850
+إذا كنت وظيفة، ولدي المال يعمل لي، ما هو اسمك؟ أنا
+
+509
+00:35:03,850 --> 00:35:05,730
+just want to sack him; I don't want him to work
+
+510
+00:35:05,730 --> 00:35:09,030
+for me anymore as my agent. Can I terminate the
+
+511
+00:35:09,030 --> 00:35:15,590
+contract?
+
+512
+00:35:15,590 --> 00:35:19,910
+Yes, it
+
+513
+00:35:19,910 --> 00:35:24,510
+can be. Yes, what
+
+514
+00:35:24,510 --> 00:35:28,370
+else? What situations? سمّيها؟
+
+515
+00:35:43,310 --> 00:35:49,370
+General principles say it can be terminated at any
+
+516
+00:35:49,370 --> 00:35:53,830
+time. It's your choice; it's your life. You would
+
+517
+00:35:53,830 --> 00:35:57,390
+like to end a contract of agency; you can end it. لا
+
+518
+00:35:57,390 --> 00:36:01,230
+أحد يستطيع أن يجعلني كمشارك أعمل لهم، ولا أستطيع
+
+519
+00:36:01,230 --> 00:36:07,390
+أن أجعل مشاركتي تعمل لدي. نحن لدينا حرية الإدارة، و
+
+520
+00:36:07,390 --> 00:36:12,930
+للعمل. الحرية تقول هنا أن مصادر المشاركين يمكن أن
+
+521
+00:36:12,930 --> 00:36:18,650
+تُنهى في أي وقت. أي وقت...في بداية الشهر، في
+
+522
+00:36:18,650 --> 00:36:24,350
+النهاية، بعد إعطاء بعض العمل، بعد إجراء عملية
+
+523
+00:36:24,350 --> 00:36:25,090
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+524
+00:36:25,090 --> 00:36:25,490
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+525
+00:36:25,490 --> 00:36:25,650
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+526
+00:36:25,650 --> 00:36:26,870
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+527
+00:36:26,870 --> 00:36:26,970
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+528
+00:36:26,970 --> 00:36:31,370
+عملية عملية عملية عملية عملية عملية. بعض الحالات، و
+
+529
+00:36:31,370 --> 00:36:33,510
+ليس دائمًا. انظر إلى ال...على سبيل المثال، هنا
+
+530
+00:36:33,510 --> 00:36:39,190
+اتفاق الـagency يُحدد بعض الطرق...بعض الطرق التي
+
+531
+00:36:39,190 --> 00:36:42,630
+نستطيع أن ننتهي منها. أو الـagency يمكن أن يتم
+
+532
+00:36:42,630 --> 00:36:47,610
+إلغاؤها. رقم واحد هو...رقم واحد. إذا عملية الـagency
+
+533
+00:36:47,610 --> 00:36:55,430
+تم إكمالها بسهولة، تعطي جيداً. خمسة PCs هي عملي، وهي
+
+534
+00:36:55,430 --> 00:37:00,500
+تريد أن تأخذها وتبيعها في السوق. She completed the
+
+535
+00:37:00,500 --> 00:37:03,240
+job; she sold the computers, and she got the money
+
+536
+00:37:03,240 --> 00:37:07,000
+and she got the commission. Job is completed; job is
+
+537
+00:37:07,000 --> 00:37:13,460
+done; job is well done. Then the agency is completed.
+
+538
+00:37:13,460 --> 00:37:17,140
+Completed; it's terminated automatically. That's
+
+539
+00:37:17,140 --> 00:37:20,500
+number one. Number two: the agent
+
+540
+00:37:20,500 --> 00:37:25,880
+can renounce the business. The agents renounce
+
+541
+00:37:25,880 --> 00:37:30,090
+يتخلون. He does not want to work anymore; he can give
+
+542
+00:37:30,090 --> 00:37:34,550
+up; he can leave it. I cannot just keep that person
+
+543
+00:37:34,550 --> 00:37:37,790
+for more time if he does not want to work for me.
+
+544
+00:37:37,790 --> 00:37:47,010
+Number four, okay.
+
+545
+00:37:47,010 --> 00:37:53,950
+But
+
+546
+00:37:53,950 --> 00:37:56,470
+suddenly the agent doesn't want to work. What can I
+
+547
+00:37:56,470 --> 00:38:02,980
+do? I might get some compensation out of him. I'm...
+
+548
+00:38:02,980 --> 00:38:06,260
+We have to look...we look at this later on in the
+
+549
+00:38:06,260 --> 00:38:09,060
+next slide. We will see in which situation we
+
+550
+00:38:09,060 --> 00:38:13,820
+cannot terminate. In general, we say you have the
+
+551
+00:38:13,820 --> 00:38:16,200
+freedom; you can end it; you can renounce; you can
+
+552
+00:38:16,200 --> 00:38:20,820
+revoke the agency. Here, the principal can revoke;
+
+553
+00:38:20,820 --> 00:38:28,340
+يُبطل، يلغي، cancel. Can cancel the contract the time
+
+554
+00:38:28,340 --> 00:38:33,540
+he or she likes. And number three: if the principal
+
+555
+00:38:33,540 --> 00:38:36,300
+being adjudicated...what's adjudicated? Do you know
+
+556
+00:38:36,300 --> 00:38:43,560
+it? Adjudicated: حُكم عليه. يعني if he was adjudicated
+
+557
+00:38:43,560 --> 00:38:50,120
+insolvent; if he or she becomes bankrupt، مفلس، then
+
+558
+00:38:50,120 --> 00:38:55,640
+if that...if the principal becomes bankrupt. أو أو أو
+
+559
+00:38:55,640 --> 00:38:56,000
+أو أو أو أو أو أو أو أو أو أو أو أو أو أو أو أو
+
+560
+00:38:56,000 --> 00:38:59,370
+أو أو أو أو أو أو أو أو. فهو لا يستطيع أن يدفع
+
+561
+00:38:59,370 --> 00:39:02,010
+المال؛ فهو لا يستطيع أن يكون رئيسًا؛ فهو لا يستطيع أن
+
+562
+00:39:02,010 --> 00:39:07,170
+يقوم بنفسه. فهنا لا يوجد مسؤولية. هنا فإن الـagency
+
+563
+00:39:07,170 --> 00:39:15,090
+تُنهى آليًا. هذا بشكل عام، ولكن في بعض الحالات يجب
+
+564
+00:39:15,090 --> 00:39:20,830
+أن تبحث عنها. بحذف بعض الحالات، لا نستطيع أن ندفع
+
+565
+00:39:20,830 --> 00:39:24,920
+المال في الـagency. As a principal, I cannot come to
+
+566
+00:39:24,920 --> 00:39:27,080
+you and say, "Well, come on, listen, I'm going to
+
+567
+00:39:27,080 --> 00:39:30,720
+terminate your agency today." It's not my option;
+
+568
+00:39:30,720 --> 00:39:34,720
+it's not my choice; I cannot do it. If I do it, I
+
+569
+00:39:34,720 --> 00:39:37,240
+would have to compensate you; I would have to pay
+
+570
+00:39:37,240 --> 00:39:42,180
+you money. One of the cases it's called here: this
+
+571
+00:39:42,180 --> 00:39:45,760
+was a question in the exam before many times. It's
+
+572
+00:39:45,760 --> 00:39:50,450
+agency coupled with interest. عندما يكون لديك سؤال
+
+573
+00:39:50,450 --> 00:39:55,350
+مثل هذا، فقط تحدث عنه. ماذا يعني ذلك؟ كيف يمكنك أن
+
+574
+00:39:55,350 --> 00:39:59,610
+تُنهيه؟ Agency coupled with interest. في هذه الحالة،
+
+575
+00:39:59,610 --> 00:40:02,030
+إذا كان لدينا agency coupled with interest،
+
+576
+00:40:02,030 --> 00:40:05,370
+فالأصل لا يمكن أن يقوم بتحريره؛ لا يمكن أن يُنهى
+
+577
+00:40:05,370 --> 00:40:08,910
+به؛ لا يمكن أن يتمكن من إبطاله. حسناً، ماذا يعني
+
+578
+00:40:08,910 --> 00:40:14,750
+ذلك؟ ماذا يعني agency coupled with interest؟ إنها
+
+579
+00:40:14,750 --> 00:40:18,010
+coupled with interest of the agent in the subject
+
+580
+00:40:18,010 --> 00:40:22,640
+matter of agency. I need to give an example to
+
+581
+00:40:22,640 --> 00:40:27,360
+explain it more. Agency coupled with...coupled with
+
+582
+00:40:27,360 --> 00:40:32,180
+يعني ممزوجة مع with interest، مصلحة of the agent
+
+583
+00:40:32,180 --> 00:40:38,180
+in the subject matter. Example; an example of this
+
+584
+00:40:38,180 --> 00:40:47,620
+like having 50 PCs, 50 laptops, 50 laptops, and I
+
+585
+00:40:47,620 --> 00:40:55,820
+gave them to...عشان أوي 50 لابتوب، عشان أُخذها لمركزها
+
+586
+00:40:55,820 --> 00:41:00,680
+ولعبتها. كل ما تريده أن تفعله هو أن تبيعها. أعطيك
+
+587
+00:41:00,680 --> 00:41:02,920
+العمولة. أبابي أبابي أبابي أبابي أبابي أبابي أبابي أبابي
+
+588
+00:41:02,920 --> 00:41:05,000
+أبابي أبابي أبابي أبابي أبابي أبابي أبابي أبابي
+
+589
+00:41:05,000 --> 00:41:07,460
+أبابي أبابي أبابي أبابي أبابي أبابي أبابي أبابي
+
+590
+00:41:07,460 --> 00:41:09,620
+أبابي أبابي أبابي أبابي أبابي أبابي أبابي أبابي
+
+591
+00:41:09,620 --> 00:41:09,640
+أبابي أبابي أبابي أبابي أبابي أبابي أبابي أبابي
+
+592
+00:41:09,640 --> 00:41:12,620
+أبا
+
+593
+00:41:22,090 --> 00:41:24,290
+الموضوع نفسه...how can we sell...can you sell
+
+594
+00:41:24,290 --> 00:41:29,960
+them in one day? Maybe...maybe not. لنقل أنها
+
+595
+00:41:29,960 --> 00:41:33,360
+كانت تعمل لـ2 أو 3 أسابيع، تحاول أن تبيعهم، ولكنها
+
+596
+00:41:33,360 --> 00:41:37,040
+قامت ببيع بعض منهم، ولكنها لم تكمل في ذلك الوقت. هل
+
+597
+00:41:37,040 --> 00:41:40,020
+يمكنني أن أقول له، "يا عزيزي، هيا، العمل قد انتهى، أنا
+
+598
+00:41:40,020 --> 00:41:43,680
+لا أريدك أن تعمل لي بعد الآن؟" لا، لا يعمل، لا يعمل
+
+599
+00:41:43,680 --> 00:41:48,580
+هكذا. يجب أن تكمل هذا العمل، يجب أن تُنهيه. لماذا؟
+
+600
+00:41:48,580 --> 00:41:53,590
+لأن في هذه الحالة، لن تحصل على المال. Unless she
+
+601
+00:41:53,590 --> 00:41:58,550
+sells all the items. It can be sometimes many items;
+
+602
+00:41:58,550 --> 00:42:03,630
+sometimes can be one item, one item, one thing, one
+
+603
+00:42:03,630 --> 00:42:06,030
+transaction. It can be sometimes one transaction
+
+604
+00:42:06,030 --> 00:42:09,090
+which costs millions, maybe hundreds of thousands of
+
+605
+00:42:09,090 --> 00:42:13,130
+pounds. Then that person will get the money out of
+
+606
+00:42:13,130 --> 00:42:15,210
+the subject matter. Can...can you read this for
+
+607
+00:42:15,210 --> 00:42:15,950
+me? جيداً.
+
+608
+00:42:23,040 --> 00:42:26,700
+The goods were consigned...consigned، تُم تحديدها
+
+609
+00:42:26,700 --> 00:42:31,060
+for the agent to sale...for sale to recoup...
+
+610
+00:42:31,060 --> 00:42:35,260
+recoup, to get his money...recoup، يستغد...يأخذ...
+
+611
+00:42:35,260 --> 00:42:40,860
+يدفع نفسه himself from the sale proceeds. We consigned
+
+612
+00:42:40,860 --> 00:42:44,800
+...هي...when the goods are consigned, consigned
+
+613
+00:42:44,800 --> 00:42:48,400
+حددنا...these goods, take them, sell, and then you
+
+614
+00:42:48,400 --> 00:42:52,840
+recoup...recoup yourself...recoup، تسترد و تدفع
+
+615
+00:42:52,840 --> 00:42:57,040
+لنفسِه himself from the sale proceeds...proceeds
+
+616
+00:42:57,040 --> 00:43:01,760
+...أوه أوه أوه
+
+617
+00:43:01,760 --> 00:43:01,800
+أوه أوه أوه أوه أوه أوه أوه أوه أوه أوه أوه
+
+618
+00:43:01,800 --> 00:43:01,960
+أوه أوه أوه أوه أوه أوه أوه أوه أوه أوه أوه
+
+619
+00:43:01,960 --> 00:43:17,360
+أوه أوه أوه أوه أو
+
+620
+00:43:20,930 --> 00:43:24,210
+نعم، في بعض الحالات...نعم، يمكن أن يكون...مثلاً، أنا
+
+621
+00:43:24,210 --> 00:43:28,570
+...أنا سأنظر إلى الوضع بعد أن أُغيّر رأيي...إنها
+
+6
+
+667
+00:46:31,240 --> 00:46:36,500
+فقط فجأة الرئيس يطلب منه أن يرحل ماذا يمكن أن
+
+668
+00:46:36,500 --> 00:46:42,340
+يفعل؟ يعرف أنه رحل بعض العمل لهذا الشخص لم يقبل
+
+669
+00:46:42,340 --> 00:46:48,440
+واحد عرض في شركة واحدة لكي تكون شركة لهذا الرئيس، ثم
+
+670
+00:46:48,440 --> 00:46:52,000
+يجب أن ننظر إلى هذه الحالة كمجلة كاملة، واحد سنة هي
+
+671
+00:46:52,000 --> 00:46:56,280
+واحد سنة، وقت مقرر هو وقت مقرر، كلاهما يجب أن يبقوا
+
+672
+00:46:56,280 --> 00:47:05,040
+مجلدهم حتى نهاية الوقت، إذا لم يكن لدينا سبب كافي
+
+673
+00:47:05,040 --> 00:47:11,040
+أنا لا أستطيع أن أخلق مجلدي، مجلدي إذا أشعر أن
+
+674
+00:47:11,040 --> 00:47:17,960
+مجلدي فعل شيء وهو غير متواضع مع عملي، شيء يمكن أن
+
+675
+00:47:17,960 --> 00:47:22,180
+يأثرني بشكل سيئ كمعاملة، شيء مثلًا هنا مثلًا، غير
+
+676
+00:47:22,180 --> 00:47:29,080
+مبادرة، غير مبادرة من أرادات قوية، يطلب... يطلب من
+
+677
+00:47:29,080 --> 00:47:32,480
+مجلدي أن يفعل شيء، لكنه ينفذ، لذلك لماذا يجب أن
+
+678
+00:47:32,480 --> 00:47:35,980
+أدفع مالِك كمجلدي، إذا لم تكن ممكن أن تفعل العمل
+
+679
+00:47:35,980 --> 00:47:39,440
+الذي أطلب منك أن تفعله، وهو حقيقي، وقد قرر في
+
+680
+00:47:39,440 --> 00:47:42,600
+التطبيقات، داخل التطبيقات والتواصلات، يجب أن
+
+681
+00:47:42,600 --> 00:47:46,780
+تتبعها، يجب أن تكون مرتبطًا، يجب أن تعمل على الرقم
+
+682
+00:47:46,780 --> 00:47:53,200
+كما أنك تتفاوض عن المجلد بينك وهو، لذلك مسبوع كافي
+
+683
+00:47:53,200 --> 00:47:57,360
+ماذا آخر؟ ما هو نوع المسبوع اللي يمكن أن يدفع
+
+684
+00:47:57,360 --> 00:48:05,780
+الرقم لإطلاق المجلد؟ لإطلاق المجلد؟ إن المجلد كان
+
+685
+00:48:05,780 --> 00:48:09,860
+حقًا... إنك لم تتوقف عن الرقم أو أنك لم تستخدم
+
+686
+00:48:09,860 --> 00:48:15,970
+المجلد. yes, if if his behavior was not nice to the
+
+687
+00:48:15,970 --> 00:48:19,350
+customers and you know sometimes not sometimes,
+
+688
+00:48:19,350 --> 00:48:23,250
+most of the time now without customer service you
+
+689
+00:48:23,250 --> 00:48:26,370
+cannot work, you have to look after the customers.
+
+690
+00:48:26,370 --> 00:48:29,650
+There is something called customer service, you
+
+691
+00:48:29,650 --> 00:48:31,630
+have to keep those customers, you have to deal with
+
+692
+00:48:31,630 --> 00:48:35,900
+them in a nice way, in a gentle way. Then if the
+
+693
+00:48:35,900 --> 00:48:39,460
+agent is dealing with them in a very bad behavior,
+
+694
+00:48:39,460 --> 00:48:42,520
+it means that we're losing the customers day after
+
+695
+00:48:42,520 --> 00:48:46,600
+day. Then it's the right for the principal to ask
+
+696
+00:48:46,600 --> 00:48:48,960
+the agent to leave. It's the right for the
+
+697
+00:48:48,960 --> 00:48:54,080
+principal to renounce, يعني ممكن يلغي، to cancel the
+
+698
+00:48:54,080 --> 00:48:58,520
+agency. And and you can like you can have other
+
+699
+00:48:58,520 --> 00:49:01,060
+situations, you can have other situations looking
+
+700
+00:49:01,060 --> 00:49:04,190
+like this situation. It's not only these reasons,
+
+701
+00:49:04,190 --> 00:49:07,170
+anything and it's sufficient or sufficient,
+
+702
+00:49:07,170 --> 00:49:10,570
+sufficient
+
+703
+00:49:10,570 --> 00:49:18,490
+reason، يعني سبب كافي، سبب مقنع، sufficient reason in
+
+704
+00:49:18,490 --> 00:49:20,830
+any case, in this situation here, if it's a fixed
+
+705
+00:49:20,830 --> 00:49:25,790
+period agency, you have to give notice, notice,
+
+706
+00:49:25,790 --> 00:49:28,810
+notice. It most likely will be like a few weeks,
+
+707
+00:49:28,810 --> 00:49:34,720
+four weeks more or less. وحتى لو كان عليك تجارب ذلك
+
+708
+00:49:34,720 --> 00:49:40,060
+الشخص، إذا كان التجارب مقررة لسنة أو ست أشهر أو خمس
+
+709
+00:49:40,060 --> 00:49:43,080
+سنة أو خمس سنة أو خمس سنة أو خمس سنة أو خمس سنة أو
+
+710
+00:49:43,080 --> 00:49:44,320
+خمس سنة أو خمس سنة أو خمس سنة أو خمس سنة أو خمس
+
+711
+00:49:44,320 --> 00:49:44,400
+سنة أو خمس سنة أو خمس سنة أو خمس سنة أو خمس
+
+712
+00:49:44,400 --> 00:49:46,660
+سنة أو خمس سنتين أو خمس سنتين أو خمس سنتين أو
+
+713
+00:49:46,660 --> 00:49:53,460
+خمس سنتين أو خمس سنتين أو خمس سنتين أو خمس سنتين
+
+714
+00:49:53,460 --> 00:49:58,440
+أو خمس سنتين أو خمس
+
+715
+00:49:59,580 --> 00:50:02,300
+I will need a compensation, you have to pay me for
+
+716
+00:50:02,300 --> 00:50:05,120
+the whole period of time. In all cases you have to
+
+717
+00:50:05,120 --> 00:50:08,960
+give notice, given by one party to the other,
+
+718
+00:50:08,960 --> 00:50:16,420
+whether they a or p, principal agent, it is a
+
+719
+00:50:16,420 --> 00:50:18,340
+warning. You cannot leave now like you know, leaving
+
+720
+00:50:18,340 --> 00:50:22,440
+me now as an agent, leaving the principal, you
+
+721
+00:50:22,440 --> 00:50:25,560
+cannot just close the shop because how much money
+
+722
+00:50:25,560 --> 00:50:30,320
+I'm gonna lose. بسبب أنك قد عشت... أعطيه وقت فقط...
+
+723
+00:50:30,320 --> 00:50:34,580
+أعطيه وقت لعدة أسابيع، وأخبرك ماذا... أكثر ممكن...
+
+724
+00:50:34,580 --> 00:50:41,020
+أكثر ممكن أن هذه المقالات تكون مكتوبة في مؤسسة كم
+
+725
+00:50:41,020 --> 00:50:44,880
+وقت أستطيع أن أعطيه لإخباره... كم وقت ممكن أن تكون
+
+726
+00:50:44,880 --> 00:50:48,300
+مؤسسة لها... كم مال ممكن أن نكون محافظين عليه...
+
+727
+00:50:48,300 --> 00:50:53,520
+كل شيء يمكن أن يكون مصطلح في مؤسسة... بين الرئيس
+
+728
+00:50:53,520 --> 00:50:56,180
+ومؤسسة... إذا لم يكن مصطلح... ماذا... ماذا يمكننا
+
+729
+00:50:56,180 --> 00:51:00,780
+فعل؟ If there is nothing... nothing was stated in
+
+730
+00:51:00,780 --> 00:51:05,840
+the agency, anyone else can answer... come on, think
+
+731
+00:51:05,840 --> 00:51:08,800
+about it a little bit, it's just logic, it's common
+
+732
+00:51:08,800 --> 00:51:17,960
+sense, anyone here... there... no, excellent.
+
+733
+00:51:17,960 --> 00:51:18,700
+That's it.
+
+734
+00:51:27,700 --> 00:51:30,160
+ممكن تتحدث عن ذلك، ممكن تتحدث عن ذلك بين رئيس و
+
+735
+00:51:30,160 --> 00:51:34,220
+مجلد، إذا لم يتمكنوا من الوصول إلى اتفاق، يمكنهم
+
+736
+00:51:34,220 --> 00:51:38,700
+الذهاب إلى القاضي، يمكنهم الذهاب إلى الانتصاف أو
+
+737
+00:51:38,700 --> 00:51:44,860
+الانتصاف، عندما يتمكن التقرير من تأثير... وهذا لم
+
+738
+00:51:44,860 --> 00:51:50,780
+يكن سؤال من قبل، عندما يتمكن التقرير من تأثير... في
+
+739
+00:51:50,780 --> 00:51:57,280
+الوقت، عندما... عندما المجلد يعرف عنه. إذا كنت سأنهي
+
+740
+00:51:57,280 --> 00:52:04,700
+مجلدي، مجلدي، فسأخبره أن المجلد قد انتهى، لا يمكنك
+
+741
+00:52:04,700 --> 00:52:10,180
+أن تعمل لدي بعد الآن، لذلك عندما يعرف المجلد عن
+
+742
+00:52:10,180 --> 00:52:16,990
+الأمر، عندما يصبح المجلد معروف له، للمستخدمين،
+
+743
+00:52:16,990 --> 00:52:21,350
+الثالثة هي أن الـagency قد انتهى، عندما يعرفوا عنها.
+
+744
+00:52:21,350 --> 00:52:25,770
+إنها عن إخبار الناس، إخبارهم أن الـagency قد
+
+745
+00:52:25,770 --> 00:52:29,330
+انتهى. احذر يا عيال، يمكنك أن تكون هناك سؤال صح أو
+
+746
+00:52:29,330 --> 00:52:35,510
+خاطئ، الكثير من الطلاب يخلصوا ولا يعرفون الإجابة.
+
+747
+00:52:35,510 --> 00:52:38,970
+و
+
+748
+00:52:38,970 --> 00:52:42,110
+حتى الـtermination للـagency يمكن أن يكون بعض
+
+749
+00:52:42,110 --> 00:52:46,890
+الأحيان بكلمات مفهومة، explicit ways or implicit
+
+750
+00:52:46,890 --> 00:52:51,810
+ways. Explicit or implicit by both ways, like we
+
+751
+00:52:51,810 --> 00:52:54,050
+said at the beginning. Come on, we said, what did we
+
+752
+00:52:54,050 --> 00:52:58,250
+say? I can make an agency or somebody factual,
+
+753
+00:52:58,250 --> 00:53:02,150
+actual agency apparent by position, so it's by
+
+754
+00:53:02,150 --> 00:53:07,570
+explicit or by implicit actions, you can terminate
+
+755
+00:53:07,570 --> 00:53:11,350
+the agency the same way we have granted it.
+
+756
+00:53:17,020 --> 00:53:20,700
+آخر ثلاثة صفحات هنا، واحدة منها هي agency و
+
+757
+00:53:20,700 --> 00:53:24,700
+partnership. آخر مرة قمت بالشرح في هذه النقطة،
+
+758
+00:53:24,700 --> 00:53:35,300
+agency
+
+759
+00:53:35,300 --> 00:53:39,800
+و partnership، partnership
+
+760
+00:53:39,800 --> 00:53:44,200
+هي شركة صغيرة، شركة صغيرة جدًا، يمكن أن تكون من
+
+761
+00:53:44,200 --> 00:53:48,060
+إثنين أشخاص أو أكثر من إثنين أشخاص. هو اتصال، اتصال
+
+762
+00:53:48,060 --> 00:53:50,820
+اتصال، اتصال، اتصال، اتصال، اتصال، اتصال، اتصال، اتصال
+
+763
+00:53:50,820 --> 00:53:52,280
+اتصال، اتصال، اتصال، اتصال، اتصال، اتصال، اتصال، اتصال
+
+764
+00:53:52,280 --> 00:53:54,400
+اتصال، اتصال، اتصال، اتصال، اتصال، اتصال، اتصال، اتصال
+
+765
+00:53:54,400 --> 00:53:55,340
+اتصال، اتصال، اتصال، اتصال، اتصال، اتصال، اتصال، اتصال
+
+766
+00:53:55,340 --> 00:53:58,140
+اتصال، اتصال، اتصال، اتصال، اتصال، اتصال، اتصال، اتصال
+
+767
+00:53:58,140 --> 00:54:15,860
+اتصال، اتصال، اتصال، اتصال، اتصال، ات
+
+768
+00:54:16,670 --> 00:54:21,410
+is an agent for all of us. We have some scholars
+
+769
+00:54:21,410 --> 00:54:26,370
+like in in English law, in English law it says that
+
+770
+00:54:26,370 --> 00:54:33,870
+partner, everyone is an agent for other partners, so
+
+771
+00:54:33,870 --> 00:54:40,850
+A is an agent for A, B, C, and D. كل واحد هو مجلد
+
+772
+00:54:40,850 --> 00:54:46,770
+للمشاركات، والسقوطية تقول: لا، ليس كذلك، جميعهم يكونوا
+
+773
+00:54:46,770 --> 00:54:50,330
+مجلد، للمجلد، للمشاركات، جميعهم
+
+774
+00:54:50,330 --> 00:54:57,050
+يكونوا مجلد
+
+775
+00:54:57,050 --> 00:54:59,990
+للمشاركات.
+
+776
+00:55:00,410 --> 00:55:03,430
+في الحياة الواقعية لا يجعلها مختلفة، إنها نفس
+
+777
+00:55:03,430 --> 00:55:07,030
+الشيء، نفس الشيء، ماذا يعني أنها نفس الشيء؟ هذا
+
+778
+00:55:07,030 --> 00:55:10,690
+يعني أن إذا كان شركة تعمل اتفاقية أو اتفاقية مع
+
+779
+00:55:10,690 --> 00:55:16,170
+المستخدمين، فهو أو هي ستجمعهم جميعًا، دعنا نقول
+
+780
+00:55:16,170 --> 00:55:22,410
+أننا لدينا A, B, C, D، أربعة أصحاب، واحدة تعمل من 8
+
+781
+00:55:22,410 --> 00:55:27,150
+في الصباح إلى 12 في الظهر، وكذلك، وكذلك، أربعة
+
+782
+00:55:27,150 --> 00:55:31,340
+تحويل، أو واحدة منهم يعمل في weekend، إذا واحد
+
+783
+00:55:31,340 --> 00:55:36,540
+منهم، واحد من المشاركين، كمشارك لكم جميعًا، قام
+
+784
+00:55:36,540 --> 00:55:41,260
+بتجارب، هذه التجارب ستقوم بتجارب الجميع من
+
+785
+00:55:41,260 --> 00:55:46,660
+المشاركين، كلهم يجب أن يكونوا مقابلين، ننظر إلى
+
+786
+00:55:46,660 --> 00:55:51,540
+المقابلة، حتى لو كان المشارك كان مخاطرًا كمشارك،
+
+787
+00:55:51,540 --> 00:55:54,660
+حتى لو كان يعمل بسرعة.
+
+788
+00:55:57,450 --> 00:56:02,210
+هي مسؤوليتنا، لدينا أربعة أو خمسة أشخاص كمشاركين، نثق
+
+789
+00:56:02,210 --> 00:56:05,690
+ببعضنا البعض، لدينا اتصال جيد، نعرف بعضنا البعض
+
+790
+00:56:05,690 --> 00:56:09,590
+بشكل جيد، ففي هذه الوضع هنا، فأي واحد منا هو
+
+791
+00:56:09,590 --> 00:56:16,690
+مشارك، ومشارك، ويجب أن نكون مخاطرين جميعنا، لذلك
+
+792
+00:56:16,690 --> 00:56:21,730
+يمكن المستخدمين أن يقوموا، أي واحد منهم، A, B, C, D أو
+
+793
+00:56:21,730 --> 00:56:26,390
+أي شخص، حتى لو كان لديه خمسين والوظيفة تستطيع
+
+794
+00:56:26,390 --> 00:56:32,170
+تجارب الجميع جمعًا، لعبادة أو لعبادات مختلفة، تستطيع
+
+795
+00:56:32,170 --> 00:56:34,610
+اختيار أي واحد منهم، تستطيع تجارب أي واحد منهم، إنه
+
+796
+00:56:34,610 --> 00:56:36,770
+يتعامل معك، إنه يتعامل مع الوظيفة، تستطيع تجارب أي
+
+797
+00:56:36,770 --> 00:56:41,850
+واحد منهم، تستطيع تجارب أي واحد منهم، تستطيع تجارب
+
+798
+00:56:41,850 --> 00:56:43,990
+أي واحد منهم، تستطيع تجارب أي واحد منهم، تستطيع
+
+799
+00:56:43,990 --> 00:56:45,330
+تجارب أي واحد منهم، تستطيع تجارب أي واحد منهم،
+
+800
+00:56:45,330 --> 00:56:47,880
+تستطيع تجارب أي واحد منهم، تستطيع تجارب، طبعًا في
+
+801
+00:56:47,880 --> 00:56:52,080
+نهاية اليوم... إذا... دعنا نقول أن واحد منهم C...
+
+802
+00:56:52,080 --> 00:56:56,120
+C لديه مجال لزيارة المستخدم... لقد أعطاه الكثير من
+
+803
+00:56:56,120 --> 00:57:01,080
+المال... ثم C يستطيع أن يعود إلى A, B, وD... هيا...
+
+804
+00:57:01,080 --> 00:57:03,700
+إنها عملنا... عليك أن تدفعه لذلك... أعني هو سيعود
+
+805
+00:57:03,700 --> 00:57:08,380
+لهم ليحصل... ليحصل على حقه... لأنها شارة متساومة
+
+806
+00:57:08,380 --> 00:57:11,960
+... أكثر من... حتى لو لم تكن شارة متساومة... فكل
+
+807
+00:57:11,960 --> 00:57:15,700
+واحد يدفع... يعتمد على كم مال يدفع... يعتمد على
+
+808
+00:57:15,700 --> 00:57:19,790
+الشارة... على الشارة... هناك شيء يسمى Notice of
+
+809
+00:57:19,790 --> 00:57:26,110
+Limitation. إذا كان واحد من المشاركين لديه قوة، قوة،
+
+810
+00:57:26,110 --> 00:57:29,450
+قوة، قوة، قوة، قوة، قوة، قوة، قوة، قوة، قوة، قوة، قوة
+
+811
+00:57:29,450 --> 00:57:31,050
+قوة، قوة، قوة، قوة، قوة، قوة، قوة، قوة، قوة، قوة، قوة
+
+812
+00:57:31,050 --> 00:57:31,130
+قوة، قوة، قوة، قوة، قوة، قوة، قوة، قوة، قوة، قوة، قوة
+
+813
+00:57:31,130 --> 00:57:31,210
+قوة، قوة، قوة، قوة، قوة، قوة، قوة، قوة، قوة، قوة، قوة
+
+814
+00:57:31,210 --> 00:57:47,670
+قوة، قوة، قوة، قو
+
+815
+00:57:50,760 --> 00:57:56,140
+لأحدهم، دعونا نقول أن B لديه قوة محددة، وهو
+
+816
+00:57:56,140 --> 00:58:03,480
+مقدر يجعل أي تجارب أقل من 200 رمز، أي تجارب أكثر من
+
+817
+00:58:03,480 --> 00:58:07,480
+200 رمز هو ليس من المفروض أن يعرفه، لذلك هو ليس
+
+818
+00:58:07,480 --> 00:58:10,920
+مقدر يجعل أي تجارب أكثر من 200 رمز، هو ليس مقدر
+
+819
+00:58:10,920 --> 00:58:14,790
+يجعل أي تجارب، أي عملية تجارب أقل من 200 ريال دولار
+
+820
+00:58:14,790 --> 00:58:24,170
+وهو الموظف لـ A, C, و D, كمعارفين للمستخدمين، أن هذا
+
+821
+00:58:24,170 --> 00:58:28,530
+المستخدم هو مستخدم، نعم، ولكنه يمكن أن يعمل عملية
+
+822
+00:58:28,530 --> 00:58:34,010
+تجارب أقل من المال، فهو ما يسمى بـ Notice of
+
+823
+00:58:34,010 --> 00:58:40,450
+Limitation. هو الموظف الأول لمعارفين الآخرين. إذا كان
+
+824
+00:58:40,450 --> 00:58:43,050
+واحد منهم... واحد من المشاركين... واحد من
+
+825
+00:58:43,050 --> 00:58:48,050
+المشاركين كان يعمل بشكل عظيم... كان يخدع
+
+826
+00:58:48,050 --> 00:58:52,870
+المستخدمين... كان يخدع... كان يعمل مع إهمال...
+
+827
+00:58:52,870 --> 00:58:57,530
+إهمال... في هذه الحالة، يمكن المستخدم الثالث أن
+
+828
+00:58:57,530 --> 00:59:02,150
+يعود لجميعهم، ليس فقط... ليس فقط لمشاركتهم، لا،
+
+829
+00:59:02,150 --> 00:59:05,510
+يمكنني أن أختار أن أرشدكم جميعًا كمستخدم، إذا
+
+830
+00:59:05,510 --> 00:59:10,580
+كنتم جميعًا مشاركين، أنا مستخدم أو ثالث مجتمع، أنا
+
+831
+00:59:10,580 --> 00:59:13,140
+أستطيع أنقذ كل المشاركين أو أنا أستطيع أنقذ واحد،
+
+832
+00:59:13,140 --> 00:59:17,400
+حتى إذا لم يكن هو الشخص الذي قدره أنقذه، لا، لأن
+
+833
+00:59:17,400 --> 00:59:23,120
+لديك مسؤولية مشتركة، مسؤولية مشتركة، فهذا هو الحال،
+
+834
+00:59:23,120 --> 00:59:27,760
+حتى هنا، دعونا نرى إذا المشارك يعمل ضد اهتمامه،
+
+835
+00:59:27,760 --> 00:59:33,000
+أحيانًا يحدث أن واحد من المشاركين مجنون، فهو يعمل ضد
+
+836
+00:59:33,000 --> 00:59:38,950
+اهتمام المشاركة، هو فقط ممكن أن يكون مخططًا لجمهور
+
+837
+00:59:38,950 --> 00:59:44,690
+ثالث مجتمع، يمكن أن يكون مخططًا، بدفع المدفع، يمكن أن
+
+838
+00:59:44,690 --> 00:59:51,690
+يدفع المستخدم الأخير، يجب أن نقول إنه ليس في الكتاب،
+
+839
+00:59:51,690 --> 00:59:55,990
+إنه فقط في المصطلح، إنه في الكتاب، أعتقد أنه نعم، نعم،
+
+840
+00:59:55,990 --> 01:00:02,890
+إنه شيء يسمى الـ brokerage. Many people mix between
+
+841
+01:00:02,890 --> 01:00:06,950
+agency and brokerage, yes, many people mix between
+
+842
+01:00:06,950 --> 01:00:09,510
+them, but in fact there is a whole difference
+
+843
+0
+
+889
+01:03:48,280 --> 01:03:50,380
+بتكرار و تكرار و تكرار و تكرار و تكرار و تكرار و
+
+890
+01:03:50,380 --> 01:03:53,920
+تكرار و تكرار و تكرار و تكرار و تكرار و تكرار و
+
+891
+01:03:53,920 --> 01:03:54,240
+تكرار و تكرار و تكرار و تكرار و تكرار و تكرار و
+
+892
+01:03:54,240 --> 01:03:54,360
+تكرار و تكرار و تكرار و تكرار و تكرار و تكرار و
+
+893
+01:03:54,360 --> 01:03:54,900
+تكرار و تكرار و تكرار و تكرار و تكرار و تكرار و
+
+894
+01:03:54,900 --> 01:03:58,360
+تكرار و تكرار و تكرار و تكرار و تكرار و تكرار و
+
+895
+01:03:58,360 --> 01:04:04,400
+تكرار و تكرار و
+
+896
+01:04:04,400 --> 01:04:08,850
+تكرار و تهو يمكنه أن يقوم بإشتراك التجارة لكن ليس
+
+897
+01:04:08,850 --> 01:04:10,730
+الـ broker، الـ broker لا يمكنه أن يقوم بإشتراك
+
+898
+01:04:10,730 --> 01:04:11,850
+التجارة، لا يمكنه أن يقوم بإخلاء التجارة، لا يمكنه
+
+899
+01:04:11,850 --> 01:04:15,130
+أن يفعل أي شيء، فهو فقط .. أعني بطريقة عامة لا
+
+900
+01:04:15,130 --> 01:04:20,610
+يمكنه أن يتعامل مع الـ .. مع المستخدم، واحد من الـ ..
+
+901
+01:04:20,610 --> 01:04:26,170
+واحد من أهم نقطة .. نقطة التي هي حقا مهمة هي
+
+902
+01:04:26,170 --> 01:04:33,130
+المخالفة، نعرف أن الوظيفة مخالفة تجاه الرئيس و تجاه
+
+903
+01:04:33,130 --> 01:04:38,400
+المستخدم، لكن الـ broker ماذا تفكر؟ he's not liable
+
+904
+01:04:38,400 --> 01:04:42,280
+the broker is not liable once the contract is done, or
+
+905
+01:04:42,280 --> 01:04:44,400
+even if it's not done, it's not his liability; he
+
+906
+01:04:44,400 --> 01:04:47,680
+doesn't care; he just gets the money and just keeps
+
+907
+01:04:47,680 --> 01:04:50,680
+doing the same business. The broker has no liability.
+
+908
+01:04:50,680 --> 01:04:57,300
+Okay, thanks very much for your time. Thank you, and
+
+909
+01:04:57,300 --> 01:05:01,480
+I'm gonna see you next week. خلاص أنا
+
diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/PMSt3QPxbME_raw.srt b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/PMSt3QPxbME_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..e4f1c41998099287f16037216d14ca688a61fb3b
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/PMSt3QPxbME_raw.srt
@@ -0,0 +1,3804 @@
+1
+00:00:09,440 --> 00:00:12,920
+Stellar agent this is the traditional role where
+
+2
+00:00:12,920 --> 00:00:17,400
+the salesman represents a person or company on the
+
+3
+00:00:17,400 --> 00:00:21,700
+selling end of a deal the second type which is the
+
+4
+00:00:21,700 --> 00:00:25,260
+buyer broker or buyer brokerage which is the
+
+5
+00:00:25,260 --> 00:00:29,110
+opposite of sales brokerهذا المكان الذي يتم تصميمه
+
+6
+00:00:29,110 --> 00:00:32,630
+الشرطة للشركات لتصميم الأشياء التي تتم تصميمها
+
+7
+00:00:32,630 --> 00:00:35,890
+الشركات. هذا هو الشيء يتم تطبيقه أكتر في تجارب
+
+8
+00:00:35,890 --> 00:00:42,550
+كبيرة. حسنا، والآن سنتحدث عن الطريقة الثالثة وهي
+
+9
+00:00:42,550 --> 00:00:47,880
+الـ Disclosed Dual AgentsOkay, the clause dual
+
+10
+00:00:47,880 --> 00:00:52,080
+agents, dual means مزدوج which contain the both
+
+11
+00:00:52,080 --> 00:00:55,380
+parties. This is where the salesman represent both
+
+12
+00:00:55,380 --> 00:01:00,620
+parties in the sales process and act as a mediator
+
+13
+00:01:00,620 --> 00:01:04,640
+for the transaction. The role of the salesman here
+
+14
+00:01:04,640 --> 00:01:08,240
+is to oversee that both parties receive an honest
+
+15
+00:01:08,240 --> 00:01:12,680
+and fair deal and is responsible for both.الأربعى
+
+16
+00:01:12,680 --> 00:01:17,980
+هو Transaction Broker وهو عكس الوظيفة وهو الوضع
+
+17
+00:01:17,980 --> 00:01:22,280
+اللي يتعامل مع المجلد اللي يتعامل مع المجلد اللي
+
+18
+00:01:22,280 --> 00:01:24,340
+يتعامل مع المجلد اللي يتعامل مع المجلد اللي يتعامل
+
+19
+00:01:24,340 --> 00:01:24,340
+مع المجلد اللي يتعامل مع المجلد اللي يتعامل مع
+
+20
+00:01:24,340 --> 00:01:24,400
+المجلد اللي يتعامل مع المجلد اللي يتعامل مع المجلد
+
+21
+00:01:24,400 --> 00:01:24,720
+اللي يتعامل مع المجلد اللي يتعامل مع المجلد اللي
+
+22
+00:01:24,720 --> 00:01:25,900
+يتعامل مع المجلد اللي يتعامل مع المجلد اللي يتعامل
+
+23
+00:01:25,900 --> 00:01:32,080
+مع المجلد اللي يتعامل مع المجلد اللي يتعامل مع
+
+24
+00:01:32,080 --> 00:01:36,160
+المجلد اللي
+
+25
+00:01:36,160 --> 00:01:39,860
+يتع
+
+26
+00:01:41,840 --> 00:01:45,040
+Sales outsourcing، outsourcing it means it's from
+
+27
+00:01:45,040 --> 00:01:49,920
+an external entity involves direct branded
+
+28
+00:01:49,920 --> 00:01:52,500
+representation where the sales representatives are
+
+29
+00:01:52,500 --> 00:01:55,860
+recruited hired and managed by an external entity
+
+30
+00:01:55,860 --> 00:02:00,180
+but hold what is represent themselves as the brand
+
+31
+00:02:00,180 --> 00:02:03,960
+of client and report all activities through their
+
+32
+00:02:03,960 --> 00:02:07,020
+own sales management channels back to the client
+
+33
+00:02:07,020 --> 00:02:10,860
+it's akin to a virtual extension of Salesforce
+
+34
+00:02:14,320 --> 00:02:18,820
+Okay، here we have sales managers qualified and
+
+35
+00:02:18,820 --> 00:02:22,160
+talented sales managers absolutely aimed to
+
+36
+00:02:22,160 --> 00:02:25,980
+implement various sales strategies and management
+
+37
+00:02:25,980 --> 00:02:31,320
+techniques in order to facilitate improved profit
+
+38
+00:02:31,320 --> 00:02:34,840
+and increase sales volumes They are also
+
+39
+00:02:34,840 --> 00:02:37,600
+responsible for coordinating the sales and
+
+40
+00:02:37,600 --> 00:02:40,920
+marketing department as well as oversight
+
+41
+00:02:42,080 --> 00:02:46,040
+concerning the fair and honest execution of the
+
+42
+00:02:46,040 --> 00:02:51,440
+sales process by their agents okay the final type
+
+43
+00:02:51,440 --> 00:02:56,720
+which is salesman okay the primary function of a
+
+44
+00:02:56,720 --> 00:03:00,560
+professional sales is to generate and close lead
+
+45
+00:03:00,560 --> 00:03:06,060
+educated prospectsFilm needs and satisfy wants of
+
+46
+00:03:06,060 --> 00:03:09,860
+consumers appropriately and therefore turn
+
+47
+00:03:09,860 --> 00:03:14,380
+prospective customers into actual ones They can do
+
+48
+00:03:14,380 --> 00:03:17,480
+this by questioning which is to understand a
+
+49
+00:03:17,480 --> 00:03:20,500
+customer goal and requirements relevant to the
+
+50
+00:03:20,500 --> 00:03:27,090
+productوإنشاء حلول قيمة بمشاركة المعلومات المحتاجة
+
+51
+00:03:27,090 --> 00:03:29,950
+للمعلومات المحتاجة للمعلومات المحتاجة للمعلومات
+
+52
+00:03:29,950 --> 00:03:30,270
+المحتاجة للمعلومات المحتاجة للمعلومات المحتاجة
+
+53
+00:03:30,270 --> 00:03:31,870
+للمعلومات المحتاجة للمعلومات المحتاجة للمعلومات
+
+54
+00:03:31,870 --> 00:03:31,910
+المحتاجة للمعلومات المحتاجة للمعلومات المحتاجة
+
+55
+00:03:31,910 --> 00:03:32,090
+للمعلومات المحتاجة للمعلومات المحتاجة للمعلومات
+
+56
+00:03:32,090 --> 00:03:32,090
+المحتاجة للمعلومات المحتاجة للمعلومات المحتاجة
+
+57
+00:03:32,090 --> 00:03:32,090
+للمعلومات المحتاجة للمعلومات المحتاجة للمعلومات
+
+58
+00:03:32,090 --> 00:03:32,190
+المحتاجة للمعلومات المحتاجة للمعلومات المحتاجة
+
+59
+00:03:32,190 --> 00:03:35,810
+للمعلومات
+
+60
+00:03:35,810 --> 00:03:42,880
+المحتاجة للمعلومات المحتاجة لOkay, now I will talk
+
+61
+00:03:42,880 --> 00:03:47,480
+about the benefits of sales agents Okay, you can
+
+62
+00:03:47,480 --> 00:03:51,500
+reach your customers effectively by using a sales
+
+63
+00:03:51,500 --> 00:03:54,980
+agent Instead of having to recruit or train and
+
+64
+00:03:54,980 --> 00:03:58,300
+finance your own employee, you can use an outside
+
+65
+00:03:58,300 --> 00:04:01,640
+sales agency A good sales agent should already
+
+66
+00:04:01,640 --> 00:04:06,920
+have the necessary contracts and skillsالفائعات من
+
+67
+00:04:06,920 --> 00:04:09,620
+مؤسسات التسلسل هي أن تستخدم مؤسسات التسلسل لبناء
+
+68
+00:04:09,620 --> 00:04:10,960
+تسلسل بدون عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+69
+00:04:10,960 --> 00:04:12,040
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+70
+00:04:12,040 --> 00:04:14,320
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+71
+00:04:14,320 --> 00:04:14,560
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+72
+00:04:14,560 --> 00:04:14,600
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+73
+00:04:14,600 --> 00:04:14,600
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+74
+00:04:14,600 --> 00:04:15,280
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+75
+00:04:15,280 --> 00:04:24,140
+عمل عمل عمل عمل عمل عمل عمل عمل
+
+76
+00:04:24,140 --> 00:04:34,800
+ع
+
+77
+00:04:34,880 --> 00:04:44,160
+it takes you time as
+
+78
+00:04:44,160 --> 00:04:48,020
+you
+
+79
+00:04:48,020 --> 00:04:49,700
+can see that next week we're gonna have two
+
+80
+00:04:49,700 --> 00:04:53,140
+students so that's next week did you present
+
+81
+00:04:53,140 --> 00:04:59,420
+anything before? the first time? okay okay one of
+
+82
+00:04:59,420 --> 00:05:03,340
+you you can choose you're gonna next weekعند
+
+83
+00:05:03,340 --> 00:05:07,740
+ميكافجة ميكافجة يمكنك اختيار اي شخص الذي سيقوم
+
+84
+00:05:07,740 --> 00:05:12,700
+بمقالة المقالة المقالة المقالة المقالة المقالة
+
+85
+00:05:12,700 --> 00:05:15,160
+المقالة المقالة المقالة المقالة المقالة المقالة
+
+86
+00:05:15,160 --> 00:05:15,580
+المقالة المقالة المقالة المقالة المقالة المقالة
+
+87
+00:05:15,580 --> 00:05:19,040
+المقالة المقالة المقالة المقالة المقالة المقالة
+
+88
+00:05:19,040 --> 00:05:23,320
+المقالة المقالة المقالة المقالة المقالة المقالة
+
+89
+00:05:23,320 --> 00:05:23,320
+المقالة المقالة المقالة المقالة المقالة المقالة
+
+90
+00:05:23,320 --> 00:05:23,340
+المقالة المقالة المقالة المقالة المقالة المقالة
+
+91
+00:05:23,340 --> 00:05:30,000
+المقالة المقالة المقالة المقالة المقالة المقالة
+
+92
+00:05:31,320 --> 00:05:34,960
+complete what we have in A juncy so next week we
+
+93
+00:05:34,960 --> 00:05:38,180
+will start with chapter 4 next week with chapter 4
+
+94
+00:05:38,180 --> 00:05:42,780
+according to me what we have is to complete A
+
+95
+00:05:42,780 --> 00:05:46,500
+juncy chapter then we will have an open discussion
+
+96
+00:05:46,500 --> 00:05:50,120
+about what we have left in this chapter and other
+
+97
+00:05:50,120 --> 00:05:53,240
+chapters like you know for the past few weeks four
+
+98
+00:05:53,240 --> 00:05:57,360
+weeks now we have to evaluate what we hadتقول
+
+99
+00:05:57,360 --> 00:05:59,980
+listen to .. what's your name? عنود .. listen to
+
+100
+00:05:59,980 --> 00:06:04,060
+عنود and then you can ask hello everybody, I wanna
+
+101
+00:06:04,060 --> 00:06:07,600
+talk today about the franchising I think that all
+
+102
+00:06:07,600 --> 00:06:12,620
+of you know about the franchising, I wanna talk
+
+103
+00:06:12,620 --> 00:06:15,720
+about it today franchising .. franchising it's a
+
+104
+00:06:15,720 --> 00:06:18,640
+contract between two independent parties that they
+
+105
+00:06:18,640 --> 00:06:22,860
+are legally and economically independent and
+
+106
+00:06:22,860 --> 00:06:25,420
+because of that one of the parties who is the
+
+107
+00:06:25,420 --> 00:06:28,870
+franchisersيعطي الشركات الأخرى للمستخدمين
+
+108
+00:06:28,870 --> 00:06:29,730
+المستخدمين المستخدمين المستخدمين المستخدمين
+
+109
+00:06:29,730 --> 00:06:31,070
+المستخدمين المستخدمين المستخدمين المستخدمين
+
+110
+00:06:31,070 --> 00:06:33,250
+المستخدمين المستخدمين المستخدمين المستخدمين
+
+111
+00:06:33,250 --> 00:06:36,150
+المستخدمين المستخدمين المستخدمين المستخدمين
+
+112
+00:06:36,150 --> 00:06:37,450
+المستخدمين المستخدمين المستخدمين المستخدمين
+
+113
+00:06:37,450 --> 00:06:38,470
+المستخدمين المستخدمين المستخدمين المستخدمين
+
+114
+00:06:38,470 --> 00:06:38,470
+المستخدمين المستخدمين المستخدمين المستخدمين
+
+115
+00:06:38,470 --> 00:06:38,470
+المستخدمين المستخدمين المستخدمين المستخدمين
+
+116
+00:06:38,470 --> 00:06:39,010
+المستخدمين المستخدمين المستخدمين المستخدمين
+
+117
+00:06:39,010 --> 00:06:45,270
+المستخدمين المستخدمين المستخدمين المستخدمين
+
+118
+00:06:45,270 --> 00:06:50,290
+المستخدمين المستخدم
+
+119
+00:06:50,310 --> 00:06:57,050
+بالنسبة له او هي المدرسة وعند مدارسه في موقع محدد
+
+120
+00:06:57,050 --> 00:07:01,450
+ومنطقة جغرافية منطقة
+
+121
+00:07:01,450 --> 00:07:05,650
+جغرافية مع موعده او هي لإعطاء المساعدة التكنيكالية
+
+122
+00:07:05,650 --> 00:07:10,210
+مع المساعدة التكنيكالية مع الحصول على إيجارات
+
+123
+00:07:10,210 --> 00:07:17,610
+مالية أو مصالحات وانتصارات اقتصادية نظر التعامل مع
+
+124
+00:07:17,610 --> 00:07:25,510
+بعضنا البعضالمعنى franchising يمكن أن يكون مصمم من
+
+125
+00:07:25,510 --> 00:07:31,870
+الكثير من التصريحات الأولى يمكننا أن نقول عنها هي
+
+126
+00:07:31,870 --> 00:07:39,430
+عملية استخدام ممارس أخرى مشهورة ممارس مشهورة ممارس
+
+127
+00:07:39,430 --> 00:07:42,770
+مشهورة ممارس مشهورة ممارس مشهورة ممارس مشهورة
+
+128
+00:07:42,770 --> 00:07:43,670
+ممارس مشهورة ممارس مشهورة ممارس مشهورة ممارس
+
+129
+00:07:43,670 --> 00:07:47,030
+مشهورة ممارس مشهورة ممارس مشهورة ممارس مشهورة
+
+130
+00:07:47,030 --> 00:07:48,170
+ممارس مشهورة ممارس مشهورة مشهورة مشهورة مشهورة
+
+131
+00:07:48,170 --> 00:07:49,250
+مشهورة مشهورة مشهورة مشهورة مشهورة مشهورة مشهورة
+
+132
+00:07:49,250 --> 00:07:52,040
+مشهورة مشهورة مشهورة مشهورة مشوهناك P.S. ليس هناك
+
+133
+00:07:52,040 --> 00:07:55,540
+قانون محدد يعتبر الـ franchising نفسه نفسه نفسه
+
+134
+00:07:55,540 --> 00:08:13,040
+نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه
+
+135
+00:08:13,200 --> 00:08:16,440
+trust and credibility expectation about the future
+
+136
+00:08:16,440 --> 00:08:22,300
+about the this relationship communication the all
+
+137
+00:08:22,300 --> 00:08:25,760
+the parties of the franchising must have well
+
+138
+00:08:25,760 --> 00:08:28,940
+skills about interacting with each others and
+
+139
+00:08:28,940 --> 00:08:33,600
+perceptionsThere are the types of franchising,
+
+140
+00:08:33,800 --> 00:08:36,600
+there are five types, five different types of
+
+141
+00:08:36,600 --> 00:08:39,880
+franchising, single, unity franchising is the
+
+142
+00:08:39,880 --> 00:08:43,520
+similar and the famous one, the second one is
+
+143
+00:08:43,520 --> 00:08:47,040
+sequential franchising, it's an alternative type
+
+144
+00:08:47,040 --> 00:08:50,140
+of franchising arrangement Can you explain it,
+
+145
+00:08:50,820 --> 00:08:53,360
+what do you mean by single and sequential?
+
+146
+00:08:57,730 --> 00:09:03,790
+الثالث هو التطور المنطقي التطور المنطقي هو تغيير
+
+147
+00:09:03,790 --> 00:09:07,710
+التجارب التجارب التجارب التجارب التجارب التجارب
+
+148
+00:09:07,710 --> 00:09:09,630
+التجارب التجارب التجارب التجارب التجارب التجارب
+
+149
+00:09:09,630 --> 00:09:12,590
+التجارب التجارب التجارب التجارب التجارب التجارب
+
+150
+00:09:12,590 --> 00:09:26,430
+التجارب
+
+151
+00:09:27,380 --> 00:09:32,220
+في أمريكا واشنطن ممكن أسأله هل لديك مثال عن الـ
+
+152
+00:09:32,220 --> 00:09:34,060
+franchising؟
+
+153
+00:09:35,420 --> 00:09:40,160
+yes when there is a successful business
+
+154
+00:09:40,160 --> 00:09:43,360
+organization have specific and successful
+
+155
+00:09:43,360 --> 00:09:49,280
+management strategies some new organization want
+
+156
+00:09:49,280 --> 00:09:55,720
+to take these strategies can give these strategies
+
+157
+00:09:55,720 --> 00:10:00,500
+by franchising from the .. do you have any name
+
+158
+00:10:00,500 --> 00:10:01,160
+for any company?
+
+159
+00:10:08,880 --> 00:10:14,060
+Okay we are coming
+
+160
+00:10:14,060 --> 00:10:19,320
+back to the same chapter we had started with
+
+161
+00:10:55,830 --> 00:11:00,850
+لذلك لم ننتهي بعد هذه الحلقة عن الوظيفة، كما ترى،
+
+162
+00:11:00,850 --> 00:11:06,350
+لدينا ثلاثة مواصلة أهمية لننظر إليها، الأولى كانت
+
+163
+00:11:06,350 --> 00:11:11,070
+الوظيفة التي كانت ممنطقة الوظيفة التي كانت ممنطقة
+
+164
+00:11:11,070 --> 00:11:13,530
+الوظيفة التي كانت ممنطقة الوظيفة التي كانت ممنطقة
+
+165
+00:11:13,530 --> 00:11:17,310
+الوظيفة التي كانت ممنطقة الوظيفة التي كانت ممنطقة
+
+166
+00:11:17,310 --> 00:11:19,410
+الوظيفة التي كانت ممنطقة الوظيفة التي كانت ممنطقة
+
+167
+00:11:19,410 --> 00:11:20,350
+الوظيفة التي كانت ممنطقة الوظيفة التي كانت ممنطقة
+
+168
+00:11:20,350 --> 00:11:20,350
+الوظيفة التي كانت ممنطقة الوظيفة التي كانت ممنطقة
+
+169
+00:11:20,350 --> 00:11:21,150
+الوظيفة التي كانت ممنطقة الوظيفة التي كانت ممنطقة
+
+170
+00:11:21,150 --> 00:11:25,240
+اللقد نظرنا في المرة الأخرى لـ Authority وكيفية
+
+171
+00:11:25,240 --> 00:11:30,000
+الوظيفة الواقعية و الواضحة و الوظيفة و الوظيفة و
+
+172
+00:11:30,000 --> 00:11:33,840
+الوظيفة و الوظيفة و الوظيفة و الوظيفة و الوظيفة و
+
+173
+00:11:33,840 --> 00:11:39,420
+الوظيفة و الوظيفة و الوظيفة و الوظيفة و الوظيفة و
+
+174
+00:11:39,420 --> 00:11:40,140
+الوظيفة و الوظيفة و الوظيفة و الوظيفة و الوظيفة و
+
+175
+00:11:40,140 --> 00:11:40,180
+الوظيفة و الوظيفة و الوظيفة و الوظيفة و الوظيفة و
+
+176
+00:11:40,180 --> 00:11:40,220
+الوظيفة و الوظيفة و الوظيفة و الوظيفة و الوظيفة و
+
+177
+00:11:40,220 --> 00:11:44,820
+الوظيفة و الوظيفة و الوظيفة و الوظيفة و الوأو
+
+178
+00:11:44,820 --> 00:11:49,320
+كلاهما عملية مجلس و رئيس .. قبل هذا .. هل لازم
+
+179
+00:11:49,320 --> 00:11:54,040
+لديك أسئلة في عقلك عن ما كانت قبلنا أو نستطيع أن
+
+180
+00:11:54,040 --> 00:11:54,700
+نكمل .. نستطيع أن نستطيع أن نستطيع أن نستطيع أن
+
+181
+00:11:54,700 --> 00:11:54,860
+نستطيع أن نستطيع أن نستطيع أن نستطيع أن نستطيع أن
+
+182
+00:11:54,860 --> 00:11:56,540
+نستطيع أن نستطيع أن نستطيع أن نستطيع أن نستطيع أن
+
+183
+00:11:56,540 --> 00:11:56,700
+نستطيع أن نستطيع أن نستطيع أن نستطيع أن نستطيع أن
+
+184
+00:11:56,700 --> 00:11:57,040
+نستطيع أن نستطيع أن نستطيع أن نستطيع أن نستطيع أن
+
+185
+00:11:57,040 --> 00:11:57,980
+نستطيع أن نستطيع أن نستطيع أن نستطيع أن نستطيع أن
+
+186
+00:11:57,980 --> 00:12:02,040
+نستطيع أن نستطيع
+
+187
+00:12:02,040 --> 00:12:11,220
+أن نستطيع أن نستطيع أن نستطagency one of the
+
+188
+00:12:11,220 --> 00:12:14,760
+easiest chapters to study and one of the most
+
+189
+00:12:14,760 --> 00:12:18,280
+practical subjects in business law and commercial
+
+190
+00:12:18,280 --> 00:12:22,160
+law I want to ask does the agent can work for the
+
+191
+00:12:22,160 --> 00:12:27,010
+many principals?وهو سؤال جيد، يجب أن نجيب على هذا
+
+192
+00:12:27,010 --> 00:12:30,590
+السؤال اليوم، هذا واحد من الأشياء التي يجب أن ننظر
+
+193
+00:12:30,590 --> 00:12:36,430
+إليها ونقررها، الواقعية، الواقعية، الأشياء، كم عدد
+
+194
+00:12:36,430 --> 00:12:40,350
+الوظيفة يمكن أن تعمل على واحد أو اثنين أو ربما
+
+195
+00:12:40,350 --> 00:12:43,710
+أكتر، سننظر إلى ذلك في الفيديو التالي، سننظر إلى
+
+196
+00:12:43,710 --> 00:12:48,750
+العمليات، عمليات الوظيفة، عمليات ما يمكن فعله
+
+197
+00:12:48,750 --> 00:12:52,570
+الوظيفة للوظيفة، ما هي الأشياء التي لديها حقوق
+
+198
+00:12:52,570 --> 00:13:01,500
+ومسؤوليةأنا أكتب هنا كمصطلح أن مصطلحي يعمل من أجلي
+
+199
+00:13:01,500 --> 00:13:08,260
+باستخدام المعلومات التي أعطاه المصطلح المصطلح لديه
+
+200
+00:13:08,260 --> 00:13:11,140
+بعض المهمات التي يجب أن تفعلها بعض الأشياء التي هي
+
+201
+00:13:11,140 --> 00:13:16,560
+المعلومات الأولى هي المعلومات المصطلح يجب أن يعطي
+
+202
+00:13:16,560 --> 00:13:21,000
+المعلومات للمصطلح كل شيء محتاجAll the information
+
+203
+00:13:21,000 --> 00:13:25,040
+needed to complete the transactions, anything we
+
+204
+00:13:25,040 --> 00:13:27,920
+think it was necessary, appointing somebody to
+
+205
+00:13:27,920 --> 00:13:29,960
+work in my place, in my company, in my business,
+
+206
+00:13:30,420 --> 00:13:33,100
+that person would have to follow my instructions,
+
+207
+00:13:33,280 --> 00:13:35,900
+but I would have to give that person the
+
+208
+00:13:35,900 --> 00:13:40,240
+instructionsمن البداية يجب أن أخبره أو هنا ماذا
+
+209
+00:13:40,240 --> 00:13:43,340
+يجب أن تفعل؟ ومتى يبدأ؟ كيف تتعامل مع المستخدمين؟
+
+210
+00:13:43,340 --> 00:13:47,620
+كم مالية ستكلفه؟ ماهي قواتك؟ ماهي مصمماتك؟ كل هذه
+
+211
+00:13:47,620 --> 00:13:52,380
+النقطة وكثير منها هم .. نسميها المعلومات ويجب أن
+
+212
+00:13:52,380 --> 00:13:57,860
+يتم إعطائها للشركة من قبل الشركة كشركة كيف يمكنني
+
+213
+00:13:57,860 --> 00:14:00,920
+أن أعمل؟ كيف يمكنني أن أتعامل مع المستخدمين؟ إذا
+
+214
+00:14:00,920 --> 00:14:06,560
+كنت لا أعرف؟ إذا لم أعرف؟لذلك يجب أن ننظر إلى حالة
+
+215
+00:14:06,560 --> 00:14:08,380
+في الواقع في الواقع في الواقع في الواقع في الواقع
+
+216
+00:14:08,380 --> 00:14:09,780
+في الواقع في الواقع في الواقع في الواقع في الواقع
+
+217
+00:14:09,780 --> 00:14:11,620
+في الواقع في الواقع في الواقع في الواقع في الواقع
+
+218
+00:14:11,620 --> 00:14:13,200
+في الواقع في الواقع في الواقع في الواقع في الواقع
+
+219
+00:14:13,200 --> 00:14:16,680
+في الواقع في الواقع في الواقع في الواقع في الواقع
+
+220
+00:14:16,680 --> 00:14:17,160
+في الواقع في الواقع في الواقع في الواقع في الواقع
+
+221
+00:14:17,160 --> 00:14:17,160
+في الواقع في الواقع في الواقع في الواقع في الواقع
+
+222
+00:14:17,160 --> 00:14:21,320
+في الواقع في الواقع في الواقع في الواقع في الواقع
+
+223
+00:14:21,320 --> 00:14:31,620
+في الواقع في الواق
+
+224
+00:14:36,780 --> 00:14:40,300
+Payments if you look back a little bit last time
+
+225
+00:14:40,300 --> 00:14:44,060
+what we had We have two types of payments one.
+
+226
+00:14:44,200 --> 00:14:47,080
+It's called liability And the second it's called
+
+227
+00:14:47,080 --> 00:14:52,240
+commission or fees Students who were sitting here
+
+228
+00:14:52,240 --> 00:14:55,460
+last time I think you still remember that we had
+
+229
+00:14:55,460 --> 00:14:58,740
+something called liability and when When the
+
+230
+00:14:58,740 --> 00:15:02,380
+principal can be liable and how much money can be
+
+231
+00:15:03,720 --> 00:15:08,800
+العامل يجب أن يساعد أو يدفع الشركة لدفعات ماهي
+
+232
+00:15:08,800 --> 00:15:13,180
+دفعات ماهي دفعات ماهي دفعة ماهي دفعة ماهي دفعة
+
+233
+00:15:13,180 --> 00:15:15,900
+ماهي دفعة ماهي دفعة ماهي دفعة ماهي دفعة ماهي دفعة
+
+234
+00:15:15,900 --> 00:15:15,900
+ماهي دفعة ماهي دفعة ماهي دفعة ماهي دفعة ماهي دفعة
+
+235
+00:15:15,900 --> 00:15:15,920
+ماهي دفعة ماهي دفعة ماهي دفعة ماهي دفعة ماهي دفعة
+
+236
+00:15:15,920 --> 00:15:16,360
+ماهي دفعة ماهي دفعة ماهي دفعة ماهي دفعة ماهي دفعة
+
+237
+00:15:16,360 --> 00:15:21,220
+ماهي دفعة ماهي دفعة ماهي دفعة ماهي دفعة ماهي دفعة
+
+238
+00:15:21,220 --> 00:15:24,820
+ماهي دفعة
+
+239
+00:15:24,820 --> 00:15:31,130
+ماهي دفعة ماهي دفإذا أعطيت شخص من خلالك أن يكون
+
+240
+00:15:31,130 --> 00:15:36,330
+عمليًا ليعمل شيء لأجلي، فسأعطي كل المعلومات
+
+241
+00:15:36,330 --> 00:15:40,970
+المحتاجة للشخص، وسأتوقع أنه أو انها ستعمل كل
+
+242
+00:15:40,970 --> 00:15:44,210
+الاختيارات المحتاجة لإكمال التعامل مع المستخدمين،
+
+243
+00:15:44,210 --> 00:15:48,250
+وفي نفس الوقت، إذا كان العملي يدفع بعض المال في
+
+244
+00:15:48,250 --> 00:15:54,320
+المدرسةإذا كان مجلدي يدفع بعض المال وكان هذا المال
+
+245
+00:15:54,320 --> 00:15:57,720
+محتاجًا لإنهاء اتفاق مع الشركة الثالثة، فأنا
+
+246
+00:15:57,720 --> 00:16:02,040
+سأجعله يدفع بعض المال إذا أعطر مجلدي أن يدفع بعض
+
+247
+00:16:02,040 --> 00:16:08,140
+المال، فأنا سأدفعه بعض المالand if he or she feels
+
+248
+00:16:08,140 --> 00:16:10,960
+that it was really necessary and important that
+
+249
+00:16:10,960 --> 00:16:13,980
+they would have to pay some money for my business
+
+250
+00:16:13,980 --> 00:16:17,040
+you pay some money for my business as my agent and
+
+251
+00:16:17,040 --> 00:16:20,040
+that was really necessary for my business then I
+
+252
+00:16:20,040 --> 00:16:22,260
+would not say no I would have to compensate you
+
+253
+00:16:22,260 --> 00:16:27,340
+call it indemnify indemnify payments that's called
+
+254
+00:16:27,340 --> 00:16:31,040
+liability liability what we have today here it's
+
+255
+00:16:31,040 --> 00:16:36,030
+not liability it's called dutythe money I would
+
+256
+00:16:36,030 --> 00:16:38,770
+have to pay you as an agent for what you did for
+
+257
+00:16:38,770 --> 00:16:42,290
+me what you did was a job you work for me as an
+
+258
+00:16:42,290 --> 00:16:45,590
+agent I pay you money as a commission and this
+
+259
+00:16:45,590 --> 00:16:48,410
+money commission for what you done for one week
+
+260
+00:16:48,410 --> 00:16:51,510
+for one month for two years it's equal to a
+
+261
+00:16:51,510 --> 00:16:54,410
+payment which is called salary it's like a salary
+
+262
+00:16:54,410 --> 00:16:58,350
+but it's called here it's called commission or
+
+263
+00:16:58,350 --> 00:17:02,190
+reasonable fee established after the fact
+
+264
+00:17:02,190 --> 00:17:08,900
+commission hereالفى لكى a prearranged if something
+
+265
+00:17:08,900 --> 00:17:12,040
+was accepted was arranged between agent and a
+
+266
+00:17:12,040 --> 00:17:14,900
+principal like say paying you a thousand dollar a
+
+267
+00:17:14,900 --> 00:17:18,800
+month that's arrangement we have done it already
+
+268
+00:17:18,800 --> 00:17:22,740
+sometimes if we don't have an agreement between
+
+269
+00:17:22,740 --> 00:17:26,520
+the agent and a principal then we would have a
+
+270
+00:17:26,520 --> 00:17:29,350
+reasonable feeعامة عامة عامة عامة عامة عامة عامة
+
+271
+00:17:29,350 --> 00:17:33,870
+عامة عامة عامة عامة عامة
+
+272
+00:17:33,870 --> 00:17:34,530
+عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة
+
+273
+00:17:34,530 --> 00:17:40,170
+عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة
+
+274
+00:17:40,170 --> 00:17:42,190
+عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة
+
+275
+00:17:42,190 --> 00:17:43,130
+عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة
+
+276
+00:17:43,130 --> 00:17:46,570
+عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة
+
+277
+00:17:46,570 --> 00:17:46,570
+عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة
+
+278
+00:17:46,570 --> 00:17:57,430
+عامة عامة
+
+279
+00:17:57,430 --> 00:18:00,860
+عامثم إذا كان لدينا هذه المقارنة، فسننظر إلى المال
+
+280
+00:18:00,860 --> 00:18:08,020
+المناسب، شيء جيد للشخص، شيء مناسب لما كان يفعله
+
+281
+00:18:08,020 --> 00:18:11,860
+لي، سننظر إلى السوق، كم يمكن أن يحصل مصاريف مصاريف
+
+282
+00:18:11,860 --> 00:18:15,140
+مصاريف مصاريف مصارف مصارف مصارف مصارف مصارف مصارف
+
+283
+00:18:15,140 --> 00:18:15,560
+مصارف مصارف مصارف مصارف مصارف مصارف مصارف مصارف
+
+284
+00:18:15,560 --> 00:18:16,040
+مصارف مصارف مصارف مصارف مصارف مصارف مصارف مصارف
+
+285
+00:18:16,040 --> 00:18:18,260
+مصارف مصارف مصارف مصارف مصارف مصارف1500 دولار 2000
+
+286
+00:18:18,260 --> 00:18:24,440
+دولار و يمكننا أن ننظر إلى المال المناسب و يمكننا
+
+287
+00:18:24,440 --> 00:18:24,540
+أن ننظر إلى المال المناسب و يمكننا أن ننظر إلى
+
+288
+00:18:24,540 --> 00:18:24,760
+المال المناسب و يمكننا أن ننظر إلى المال المناسب و
+
+289
+00:18:24,760 --> 00:18:25,580
+يمكننا أن ننظر إلى المال المناسب و يمكننا أن ننظر
+
+290
+00:18:25,580 --> 00:18:25,740
+إلى المال المناسب و يمكننا أن ننظر إلى المال
+
+291
+00:18:25,740 --> 00:18:27,260
+المناسب و يمكننا أن ننظر إلى المال المناسب و
+
+292
+00:18:27,260 --> 00:18:27,260
+يمكننا أن ننظر إلى المال المناسب و يمكننا أن ننظر
+
+293
+00:18:27,260 --> 00:18:27,260
+إلى المال المناسب و يمكننا أن ننظر إلى المال
+
+294
+00:18:27,260 --> 00:18:27,280
+المناسب و يمكننا أن ننظر إلى المال المناسب و
+
+295
+00:18:27,280 --> 00:18:27,540
+يمكننا أن ننظر إلى المال المناسب و يمكننا أن ننظر
+
+296
+00:18:27,540 --> 00:18:40,700
+إلى المال المناسب و
+
+297
+00:18:40,700 --> 00:18:47,070
+يمكننا أنالثاني عمل أو عمل مجرد مجرد مجرد مجرد
+
+298
+00:18:47,070 --> 00:18:53,650
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+299
+00:18:53,650 --> 00:18:54,030
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+300
+00:18:54,030 --> 00:18:54,110
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+301
+00:18:54,110 --> 00:18:54,190
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+302
+00:18:54,190 --> 00:19:01,310
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+303
+00:19:01,310 --> 00:19:07,270
+م
+
+304
+00:19:17,820 --> 00:19:20,620
+و ..
+
+305
+00:19:22,620 --> 00:19:27,220
+and my colleague said first .. first he must give
+
+306
+00:19:27,220 --> 00:19:30,120
+order to the principal okay he must follow ..
+
+307
+00:19:30,120 --> 00:19:34,560
+follow the construction and respect it and favor
+
+308
+00:19:34,560 --> 00:19:39,960
+it and he shouldn't follow any new publication
+
+309
+00:19:39,960 --> 00:19:43,780
+which is inconsistent with his principles or by
+
+310
+00:19:43,780 --> 00:19:49,740
+the principal he must .. are able to ..
+
+311
+00:19:52,930 --> 00:19:56,990
+و يجب أن نفهم أن المهندس يجب أن يقوم بالعمل كما
+
+312
+00:19:56,990 --> 00:20:00,940
+قلت في المهندسةappointing someone as an agent he
+
+313
+00:20:00,940 --> 00:20:04,640
+or she would have information instructions from
+
+314
+00:20:04,640 --> 00:20:07,040
+the principal telling that person what to do
+
+315
+00:20:07,040 --> 00:20:11,060
+that's my job as an agent what shall I do how much
+
+316
+00:20:11,060 --> 00:20:13,360
+transactions how many transactions can I do how
+
+317
+00:20:13,360 --> 00:20:16,520
+much money I can spend all this question would be
+
+318
+00:20:16,520 --> 00:20:19,820
+in my mind I will follow the instructions I will
+
+319
+00:20:19,820 --> 00:20:25,940
+do my job as stated in the agency contractIn
+
+320
+00:20:25,940 --> 00:20:28,740
+addition to this we have main point which is
+
+321
+00:20:28,740 --> 00:20:33,780
+loyalty being honest being loyal to the principle
+
+322
+00:20:33,780 --> 00:20:36,660
+and I guess that for you it's easy to understand
+
+323
+00:20:36,660 --> 00:20:40,240
+the meaning of loyalty someone is loyal what does
+
+324
+00:20:40,240 --> 00:20:49,200
+it mean can anyone explain it loyalty okay
+
+325
+00:21:13,090 --> 00:21:16,370
+Okay loyalty includes many aspects but one of the
+
+326
+00:21:16,370 --> 00:21:19,910
+main aspects here not to accept a new obligations
+
+327
+00:21:21,520 --> 00:21:25,560
+What kind of obligations? Obligations that are
+
+328
+00:21:25,560 --> 00:21:29,020
+inconsistent with the main job. If they were
+
+329
+00:21:29,020 --> 00:21:32,620
+consistent, that's fine. I should not do any other
+
+330
+00:21:32,620 --> 00:21:36,640
+job which can be conflicted, which can conflict
+
+331
+00:21:36,640 --> 00:21:43,120
+with my main duties. Any agent who is working for
+
+332
+00:21:43,120 --> 00:21:48,100
+someone should do the job to his best.و لا يجب أن
+
+333
+00:21:48,100 --> 00:21:51,900
+نقبل مواصلة جديدة، و لا يجب أن نعمل لأكثر من واحد
+
+334
+00:21:51,900 --> 00:21:56,060
+أسلوب، إلا إذا كان لدينا بعض الواضحات، فإذا اتبعت
+
+335
+00:21:56,060 --> 00:22:00,400
+هذه الواضحات، فسيكون بخير، ولكن عامة واحدة لواحد
+
+336
+00:22:00,400 --> 00:22:05,460
+أسلوب، ليس مواصلة جديدة، إنها غير متواصلة مع
+
+337
+00:22:05,460 --> 00:22:11,060
+العمليات، هذه ستجعل عقلنا نسأل عن الممكنة
+
+338
+00:22:14,310 --> 00:22:23,570
+هل يكون بخير او لا؟ هل يمكننا ان نواجه مهرجان يعمل
+
+339
+00:22:23,570 --> 00:22:28,570
+مع شخص اخر و يعمل معي او لا؟ هل هذا ممكن او لا؟ هل
+
+340
+00:22:28,570 --> 00:22:32,430
+يمكنني ان احتفظ بمهرجاني؟ هل يمكنني ان اوقفه من
+
+341
+00:22:32,430 --> 00:22:36,270
+العمل مع شخص اخر إلا معي؟ هذه الأسئلة يجب أن ننظر
+
+342
+00:22:36,270 --> 00:22:42,620
+عليها و نجيب عليها ما رأيك هنا؟need someone else
+
+343
+00:22:42,620 --> 00:22:45,680
+like an agent can he work for somebody else except
+
+344
+00:22:45,680 --> 00:23:01,800
+of me it's
+
+345
+00:23:01,800 --> 00:23:06,440
+possible I mean the general idea it's fine you
+
+346
+00:23:06,440 --> 00:23:08,880
+have the freedom to work for more than one
+
+347
+00:23:08,880 --> 00:23:11,940
+principal but if you would like to do itYou have
+
+348
+00:23:11,940 --> 00:23:13,660
+to be careful, you have to follow the
+
+349
+00:23:13,660 --> 00:23:16,560
+instructions, you have to tell both, we have some
+
+350
+00:23:16,560 --> 00:23:18,760
+conditions, we have to follow those conditions
+
+351
+00:23:18,760 --> 00:23:22,740
+otherwise we cannot make it I cannot just be
+
+352
+00:23:22,740 --> 00:23:25,600
+working for two people at the same time doing the
+
+353
+00:23:25,600 --> 00:23:28,560
+same job, this is what we call it's called
+
+354
+00:23:28,560 --> 00:23:35,420
+inconsistentمثل ان انا ممكن اعمل في اتن مكان و اتن
+
+355
+00:23:35,420 --> 00:23:39,840
+شركات في نفس الوقت و هؤلاء الشركات يقاتلون مثل ان
+
+356
+00:23:39,840 --> 00:23:44,380
+انا ممكن اكون مجلس .. ممكن اكون مجلس لشركة كمبيوتر
+
+357
+00:23:44,380 --> 00:23:50,370
+بي سي سيلين بي سي و LCD و إلكترونيكسأنا لا أستطيع
+
+358
+00:23:50,370 --> 00:23:53,050
+أن أعمل لدين الشركات في نفس الوقت في نفس العمل
+
+359
+00:23:53,050 --> 00:23:56,670
+لأنني أستطيع أن أفهم منذ البداية أن تلك الشركات
+
+360
+00:23:56,670 --> 00:24:01,090
+تقاتل مع بعضها البعض وإذا كنت سأعمل لديهم كلا او
+
+361
+00:24:01,090 --> 00:24:03,370
+كلا او كلا او كلا او كلا او كلا او كلا او كلا او
+
+362
+00:24:03,370 --> 00:24:04,570
+كلا او كلا او كلا او كلا او كلا او كلا او كلاأنا
+
+363
+00:24:04,570 --> 00:24:09,010
+لن .. في هذه الحالة ، أحيانًا سأقوم بتحرير أو
+
+364
+00:24:09,010 --> 00:24:15,150
+تهيئة موقعي و تهيئة موقعي و موقعي و موقعي و موقعي
+
+365
+00:24:15,150 --> 00:24:17,710
+و موقعي و موقعي و موقعي و موقعي و موقعي و موقعي و
+
+366
+00:24:17,710 --> 00:24:18,350
+موقعي و موقعي و موقعي و موقعي و موقعي و موقعي و
+
+367
+00:24:18,350 --> 00:24:18,370
+موقعي و موقعي و موقعي و موقعي و موقعي و موقعي و
+
+368
+00:24:18,370 --> 00:24:18,650
+موقعي و موقعي و موقعي و موقعي و موقعي و موقعي و
+
+369
+00:24:18,650 --> 00:24:22,150
+موقعي و موقعي و موقعي و موقعي و موقعي و موقعي و
+
+370
+00:24:22,150 --> 00:24:31,510
+موقعي و موقعي و
+
+371
+00:24:31,510 --> 00:24:32,370
+موقع
+
+372
+00:24:55,620 --> 00:25:02,640
+Okay that's fine
+
+373
+00:25:02,640 --> 00:25:08,020
+Now in factأشخاص يستطيعون أن يمثلوا أكتر من واحد
+
+374
+00:25:08,020 --> 00:25:11,100
+من المصطلح، هو أو هي يستطيعون ذلك، لديك الحرية
+
+375
+00:25:11,100 --> 00:25:16,140
+لتفعل ذلك مع تلك الوضعين في الواقع في الواقع في
+
+376
+00:25:16,140 --> 00:25:19,760
+الواقع في الواقع في الواقع في الواقع في الواقع في
+
+377
+00:25:19,760 --> 00:25:23,080
+الواقع في الواقع في الواقع
+
+378
+00:25:24,250 --> 00:25:29,350
+حتى لو استطعت أن أفهم من البداية أن عملي مع
+
+379
+00:25:29,350 --> 00:25:33,390
+المصطلح الثاني سيتفاجأ مع عملي مع المصطلح الحالي
+
+380
+00:25:33,390 --> 00:25:39,310
+في هذه الحالة أفضل طريقة أفضل حلوة هي أن تعلّم كلا
+
+381
+00:25:39,310 --> 00:25:44,410
+الاثنين ما يسمى كتابة كتابة كتابة كتابة كتابة
+
+382
+00:25:44,410 --> 00:25:51,220
+كتابة كتابةبعمل هذا أفعل أفضل ما أستطيع و أعرف ما
+
+383
+00:25:51,220 --> 00:25:54,460
+أفعله
+
+384
+00:25:54,460 --> 00:25:59,540
+و أعرف ما أفعله و
+
+385
+00:25:59,540 --> 00:26:02,520
+أعرف ما أفعله و أعرف ما أفعله و أعرف ما أفعله و
+
+386
+00:26:02,520 --> 00:26:04,660
+أعرف ما أفعله و أعرف ما أفعله و أعرف ما أفعله و
+
+387
+00:26:04,660 --> 00:26:05,460
+أعرف ما أفعله و أعرف ما أفعله و أعرف ما أفعله و
+
+388
+00:26:05,460 --> 00:26:05,460
+أعرف ما أفعله و أعرف ما أفعله و أعرف ما أفعله و
+
+389
+00:26:05,460 --> 00:26:05,460
+أعرف ما أفعله و أعرف ما أفعله و أعرف ما أفعله و
+
+390
+00:26:05,460 --> 00:26:05,480
+أعرف ما أفعله و أعرف ما أفعله و أعرف ما أفعله و
+
+391
+00:26:05,480 --> 00:26:11,900
+أعرف ما أفعله و أعرف ما أفعله و أعرف
+
+392
+00:26:11,900 --> 00:26:15,190
+ما أفعله وthen I would have to tell both of them
+
+393
+00:26:15,190 --> 00:26:20,870
+on time what I'm doing in details in order to do
+
+394
+00:26:20,870 --> 00:26:25,150
+my job as stated in the contract between me and
+
+395
+00:26:25,150 --> 00:26:30,560
+the uniأي شخص يرغب في العمل في اتصال اتصال اتصال
+
+396
+00:26:30,560 --> 00:26:39,060
+اتصال اتصال اتصال اتصال اتصال اتصال اتصال اتصال
+
+397
+00:26:39,060 --> 00:26:48,980
+اتصال اتصال
+
+398
+00:26:48,980 --> 00:26:56,720
+اتصال اتصال اتصال اتصال
+
+399
+00:26:56,720 --> 00:26:59,800
+اتصال اتصالالمهم ان تكون مستخدما و مستخدما بكل
+
+400
+00:26:59,800 --> 00:27:00,220
+المعلومات و كل المعلومات و كل المعلومات و كل
+
+401
+00:27:00,220 --> 00:27:01,380
+المعلومات و كل المعلومات و كل المعلومات و كل
+
+402
+00:27:01,380 --> 00:27:03,020
+المعلومات و كل المعلومات و كل المعلومات و كل
+
+403
+00:27:03,020 --> 00:27:04,420
+المعلومات و كل المعلومات و كل المعلومات و كل
+
+404
+00:27:04,420 --> 00:27:04,840
+المعلومات و كل المعلومات و كل المعلومات و كل
+
+405
+00:27:04,840 --> 00:27:05,020
+المعلومات و كل المعلومات و كل المعلومات و كل
+
+406
+00:27:05,020 --> 00:27:05,020
+المعلومات و كل المعلومات و كل المعلومات و كل
+
+407
+00:27:05,020 --> 00:27:05,080
+المعلومات و كل المعلومات و كل المعلومات و كل
+
+408
+00:27:05,080 --> 00:27:06,680
+المعلومات و كل المعلومات و كل المعلومات و كل
+
+409
+00:27:06,680 --> 00:27:06,760
+المعلومات و كل المعلومات و كل المعلومات و كل
+
+410
+00:27:06,760 --> 00:27:10,400
+المعلومات و كل المعلومات و كل المعلومات و كل
+
+411
+00:27:10,400 --> 00:27:19,300
+المعلومات و
+
+412
+00:27:19,300 --> 00:27:22,890
+كل المعلyou can do it with the first condition and
+
+413
+00:27:22,890 --> 00:27:25,670
+in addition to this you have to prevent any
+
+414
+00:27:25,670 --> 00:27:29,450
+situation you have to stop any situation in which
+
+415
+00:27:29,450 --> 00:27:34,090
+my job as an agent or your job as an agent will
+
+416
+00:27:34,090 --> 00:27:39,970
+jeopardize one of the principles work or interest
+
+417
+00:27:39,970 --> 00:27:42,090
+especially work
+
+418
+00:27:46,680 --> 00:27:50,220
+yes yes I mean I should not compromise the
+
+419
+00:27:50,220 --> 00:27:54,200
+principal's position as an agent he or she as an
+
+420
+00:27:54,200 --> 00:27:58,060
+agent should not jeopardize should not compromise
+
+421
+00:27:58,060 --> 00:28:06,040
+compromise like what does it mean for you it's
+
+422
+00:28:06,040 --> 00:28:08,440
+not negotiated like working for somebody at the
+
+423
+00:28:08,440 --> 00:28:11,560
+expense of the second person I do work for you but
+
+424
+00:28:11,560 --> 00:28:16,270
+at the expense of that personcompromise has two
+
+425
+00:28:16,270 --> 00:28:19,310
+meanings compromise it can be like a middle
+
+426
+00:28:19,310 --> 00:28:22,970
+solution for two person and it can be in this case
+
+427
+00:28:22,970 --> 00:28:25,690
+it's not a middle solution it's kind of trying to
+
+428
+00:28:25,690 --> 00:28:31,290
+undermine يقلل أو لا يفعل not doing my job as
+
+429
+00:28:31,290 --> 00:28:34,790
+stated compromise not doing what I was supposed to
+
+430
+00:28:34,790 --> 00:28:38,990
+do this is compromise in this case my agency is
+
+431
+00:28:38,990 --> 00:28:44,420
+not it's not gonna be legalI'm not doing it as
+
+432
+00:28:44,420 --> 00:28:47,520
+stated in the contract this is what's called a
+
+433
+00:28:47,520 --> 00:28:51,860
+breach مخالفة of the agency so if you want to work
+
+434
+00:28:51,860 --> 00:28:55,780
+for two you have to be careful not to affect one
+
+435
+00:28:55,780 --> 00:28:59,360
+of them at the expense of the other not to be
+
+436
+00:28:59,360 --> 00:29:02,520
+working for somebody at the expense of the other
+
+437
+00:29:02,520 --> 00:29:05,800
+like like somebody let's say that what what the
+
+438
+00:29:05,800 --> 00:29:08,000
+what the famous companies you have here in Gaza a
+
+439
+00:29:08,000 --> 00:29:11,080
+famous company you have what companies do you have
+
+440
+00:29:13,130 --> 00:29:17,450
+تلكوميكاشن شركة حضارة انترنت تلكوميكاشن حضارة
+
+441
+00:29:17,450 --> 00:29:19,390
+انترنت تلكوميكاشن حضارة انترنت تلكوميكاشن حضارة
+
+442
+00:29:19,390 --> 00:29:26,930
+انترنت تلكوميكاشن
+
+443
+00:29:26,930 --> 00:29:26,950
+حضارة انترنت تلكوميكاشن حضارة انترنت تلكوميكاشن
+
+444
+00:29:26,950 --> 00:29:26,950
+حضارة انترنت تلكوميكاشن حضارة انترنت تلكوميكاشن
+
+445
+00:29:26,950 --> 00:29:26,950
+حضارة انترنت تلكوميكاشن حضارة انترنت تلكوميكاشن
+
+446
+00:29:26,950 --> 00:29:26,990
+حضارة انترنت تلكوميكاشن حضارة انترنت تلكوميكاشن
+
+447
+00:29:26,990 --> 00:29:34,650
+حضارة انترنت تلكوميكاشن حضارة انترنت تلكوميكاشن
+
+448
+00:29:34,650 --> 00:29:37,450
+حضارة
+
+449
+00:29:38,520 --> 00:29:41,040
+she can do the job because she's really good,
+
+450
+00:29:41,440 --> 00:29:44,880
+she's consistent, she's very skilled, educated
+
+451
+00:29:44,880 --> 00:29:47,760
+person and she can communicate with the customers,
+
+452
+00:29:47,920 --> 00:29:50,360
+she can get so many customers from both companies
+
+453
+00:29:50,360 --> 00:29:53,560
+in this case it's fine you can do .. she can do
+
+454
+00:29:53,560 --> 00:29:56,800
+the job but she has to be consistent all the time
+
+455
+00:29:58,270 --> 00:30:02,150
+لا يجب أن تقوم واحد منهم بمساعدة نفس المستخدم في
+
+456
+00:30:02,150 --> 00:30:07,050
+الصباح و الصباح بينما يقول إن هذا مقارنة بالإهتمام
+
+457
+00:30:07,050 --> 00:30:11,190
+إنها مقارنة بالإهتمام، لا يمكنها أن تفعلها، عليها
+
+458
+00:30:11,190 --> 00:30:13,990
+أن تكون مستمرة ومقارنة، عليها أن تقوم بمقارنة بين
+
+459
+00:30:13,990 --> 00:30:19,770
+العملين العاملين بالإضافة إلى كل هذا، إذا تنظر إلى
+
+460
+00:30:19,770 --> 00:30:26,710
+هذا النقطة هنا في بعض الأحيان، لا يجب أن يكون
+
+461
+00:30:26,710 --> 00:30:30,850
+المهندس لديه مسموحإذا كنت تعمل كشركة لشركة واحدة،
+
+462
+00:30:30,850 --> 00:30:33,990
+فلا يجب عليك أن تكون لديك إسم مسموح، لا إقبال من
+
+463
+00:30:33,990 --> 00:30:40,350
+المصطلح، فلو كان هناك شيء مصطلح في مجلس الشركة
+
+464
+00:30:40,350 --> 00:30:47,850
+بينك كشركة ومصطلح الشركة، فهذه النقطة مصطلحة في
+
+465
+00:30:47,850 --> 00:30:53,660
+مجلس الشركةإذا كانت أي عملية من هذه النقطة كانت
+
+466
+00:30:53,660 --> 00:30:59,440
+مقبلة وقبلة من نفسي كمسؤول وكمسؤول فهو بخير في
+
+467
+00:30:59,440 --> 00:31:01,780
+المستقبل إذا كنت تريد أن تقوم بأي من هذه العملية
+
+468
+00:31:01,780 --> 00:31:11,270
+إذا قلت في مجلستي ومسؤولتي أنني سأعمل لك كمسؤولI
+
+469
+00:31:11,270 --> 00:31:16,130
+would be teaching for so and so companies I would
+
+470
+00:31:16,130 --> 00:31:19,350
+be working as a consultant for other two companies
+
+471
+00:31:19,350 --> 00:31:22,690
+at the same time in the future he or she as a
+
+472
+00:31:22,690 --> 00:31:26,030
+principal will not be able to come back to me say
+
+473
+00:31:26,030 --> 00:31:28,310
+well you should not do it because in the same
+
+474
+00:31:28,310 --> 00:31:31,510
+contract of agency between principal and agent
+
+475
+00:31:31,510 --> 00:31:37,100
+this agency itself has statedكل المهارات التي قد
+
+476
+00:31:37,100 --> 00:31:39,740
+تم إقناعها من كلا الجانبين مهارة و رئيس مهارة
+
+477
+00:31:39,740 --> 00:31:45,120
+فالمهارة ستكون لديها الحرص في المستقبل لتعمل على
+
+478
+00:31:45,120 --> 00:31:50,440
+هذه المهارات دون أن تتحدث مع الرئيس دون أن تسأله
+
+479
+00:31:50,440 --> 00:32:00,000
+عن إسمه هذا كل شيء رقم واحد عن المواجهات الاخر هو
+
+480
+00:32:03,090 --> 00:32:05,830
+هل تستطيع أن تجعل العميل يتعامل مع الشركات أو
+
+481
+00:32:05,830 --> 00:32:09,450
+يتعامل مع الشركات و يتعامل مع الشركات و يتعامل مع
+
+482
+00:32:09,450 --> 00:32:10,270
+الشركات و يتعامل مع الشركات و يتعامل مع الشركات و
+
+483
+00:32:10,270 --> 00:32:11,090
+يتعامل مع الشركات و يتعامل مع الشركات و يتعامل مع
+
+484
+00:32:11,090 --> 00:32:12,490
+الشركات و يتعامل مع الشركات و يتعامل مع الشركات و
+
+485
+00:32:12,490 --> 00:32:14,470
+يتعامل مع الشركات و يتعامل مع الشركات و يتعامل مع
+
+486
+00:32:14,470 --> 00:32:14,950
+الشركات و يتعامل مع الشركات و يتعامل مع الشركات و
+
+487
+00:32:14,950 --> 00:32:20,150
+يتعامل مع الشركات و يتعامل مع الشركات و يتعامل مع
+
+488
+00:32:20,150 --> 00:32:30,050
+الشركات و يتعامل مع الشركات و يتعامل مع الشركات و
+
+489
+00:32:30,050 --> 00:32:34,910
+ييستطيع استخدام المكان و الموقع و العمل لتجارب
+
+490
+00:32:34,910 --> 00:32:41,210
+نفسه و هذا غير مسموح و احد عمليه الأسهم للشركة هي
+
+491
+00:32:41,210 --> 00:32:45,490
+انها لا تقبل او لا تجعل .. انا أسف .. لا تجعل نفسه
+
+492
+00:32:45,490 --> 00:32:52,990
+ناجح بشكل خاص أو خاطئمثل ماذا؟ بعض الأشخاص يستخدم
+
+493
+00:32:52,990 --> 00:32:56,570
+السيارة أو السيارة أو السيارة أو السيارة أو
+
+494
+00:32:56,570 --> 00:32:59,310
+السيارة أو السيارة أو السيارة أو السيارة أو
+
+495
+00:32:59,310 --> 00:32:59,310
+السيارة أو السيارة أو السيارة أو السيارة أو
+
+496
+00:32:59,310 --> 00:32:59,310
+السيارة أو السيارة أو السيارة أو السيارة أو
+
+497
+00:32:59,310 --> 00:33:00,530
+السيارة أو السيارة أو السيارة أو السيارة أو
+
+498
+00:33:00,530 --> 00:33:00,530
+السيارة أو السيارة أو السيارة أو السيارة أو
+
+499
+00:33:00,530 --> 00:33:01,010
+السيارة أو السيارة أو السيارة أو السيارة أو
+
+500
+00:33:01,010 --> 00:33:01,810
+السيارة أو السيارة أو السيارة أو السيارة أو
+
+501
+00:33:01,810 --> 00:33:02,670
+السيارة أو السيارة أو السيارة أو السيارة أو
+
+502
+00:33:02,670 --> 00:33:09,030
+السيارة أو السيارة أو السيارة أو السيارة أو
+
+503
+00:33:09,030 --> 00:33:15,410
+السيارة أو
+
+504
+00:33:15,410 --> 00:33:19,560
+السيhe or she as an agent supposed only to sell in
+
+505
+00:33:19,560 --> 00:33:22,940
+this company in this store commodities commodities
+
+506
+00:33:22,940 --> 00:33:25,640
+and items belong to the principal some of them
+
+507
+00:33:25,640 --> 00:33:29,180
+what they do they get some goods and items in the
+
+508
+00:33:29,180 --> 00:33:31,680
+same place and they sell them for the agent for
+
+509
+00:33:31,680 --> 00:33:35,760
+himself this is illegal it's not allowed and the
+
+510
+00:33:35,760 --> 00:33:38,460
+principal can sue the agent for this he can sack
+
+511
+00:33:38,460 --> 00:33:41,810
+himوهناك الكثير من الأمثلة من خلال هذا البرنامج
+
+512
+00:33:41,810 --> 00:33:47,770
+انا أعرف شركات هنا و بعضهم .. بعضهم كعامل يمنحوا
+
+513
+00:33:47,770 --> 00:33:51,230
+مكان للوظيفة انا أعني حسنا يمكنك استخدام السيارة
+
+514
+00:33:51,230 --> 00:33:56,310
+يمكنك استخدام المكان ولكن لـso and so هم هم هم هم
+
+515
+00:33:56,310 --> 00:33:57,030
+هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم
+
+516
+00:33:57,030 --> 00:33:58,250
+هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم
+
+517
+00:33:58,250 --> 00:33:58,350
+هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم هم
+
+518
+00:33:58,350 --> 00:34:06,950
+هم هم هم هم هم هم هم هم هم هم هم هم
+
+519
+00:34:06,950 --> 00:34:10,610
+هليس لإنجاز نفسي و ليس لإيغتناء بشكل صحيح لإنجاز
+
+520
+00:34:10,610 --> 00:34:12,150
+نفسي و ليس لإيغتناء بشكل صحيح لإيغتناء بشكل صحيح
+
+521
+00:34:12,150 --> 00:34:16,290
+لإيغتناء بشكل صحيح لإيغتناء بشكل صحيح لإيغتناء
+
+522
+00:34:16,290 --> 00:34:18,130
+بشكل صحيح لإيغتناء بشكل صحيح لإيغتناء بشكل صحيح
+
+523
+00:34:18,130 --> 00:34:20,270
+لإيغتناء بشكل صحيح لإيغتناء بشكل صحيح لإيغتناء
+
+524
+00:34:20,270 --> 00:34:25,790
+بشكل صحيح لإيغتناء بشكل صحيح لإيغتناء بشكل صحيح
+
+525
+00:34:25,790 --> 00:34:29,670
+لإيغتناء بشكل صحيح لإيغ
+
+526
+00:34:35,470 --> 00:34:43,090
+عن كيف ننتهي و كيف ننهي شركتي بسهولة أو صعبة؟ إذا
+
+527
+00:34:43,090 --> 00:34:49,590
+كنت شركتي و كنت أرغب أن أنتهي أو أنهي شركتي، هل
+
+528
+00:34:49,590 --> 00:34:57,690
+أستطيع؟ بأي وقت؟ هل أنت متأكد؟ يتعامل مع الوظيفة؟
+
+529
+00:34:57,690 --> 00:35:03,850
+إذا كنت وظيفة و لدي المال يعمل لي، ما هو إسمك؟أنا
+
+530
+00:35:03,850 --> 00:35:05,730
+just want to sack here, I don't want here to work
+
+531
+00:35:05,730 --> 00:35:09,030
+for me anymore as my agent, can I terminate the
+
+532
+00:35:09,030 --> 00:35:15,590
+contract؟
+
+533
+00:35:15,590 --> 00:35:19,910
+yes it
+
+534
+00:35:19,910 --> 00:35:24,510
+can be yes what
+
+535
+00:35:24,510 --> 00:35:28,370
+else? what situations؟ سميها؟
+
+536
+00:35:43,310 --> 00:35:49,370
+general principles say it can be terminated at any
+
+537
+00:35:49,370 --> 00:35:53,830
+time it's your choice it's your life you would
+
+538
+00:35:53,830 --> 00:35:57,390
+like to end a contract of agency you can end itلا
+
+539
+00:35:57,390 --> 00:36:01,230
+أحد يستطيع أن يجعلني كمشاركة أعمل لهم و لا أستطيع
+
+540
+00:36:01,230 --> 00:36:07,390
+أن أجعل مشاركتي أعمل لدي نحن لدينا حرية للإدارة و
+
+541
+00:36:07,390 --> 00:36:12,930
+للعمل حرية تقول هنا أن مصادر المشاركين يمكن ان
+
+542
+00:36:12,930 --> 00:36:18,650
+يتموت في أي وقتأي وقت .. في البداية للشهر، في
+
+543
+00:36:18,650 --> 00:36:24,350
+النهاية، بعد إعطاء بعض العمل، بعد إجراء عملية
+
+544
+00:36:24,350 --> 00:36:25,090
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+545
+00:36:25,090 --> 00:36:25,490
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+546
+00:36:25,490 --> 00:36:25,650
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+547
+00:36:25,650 --> 00:36:26,870
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+548
+00:36:26,870 --> 00:36:26,970
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+549
+00:36:26,970 --> 00:36:26,970
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+550
+00:36:26,970 --> 00:36:26,970
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+551
+00:36:26,970 --> 00:36:31,370
+عملية عملية عملية عملية عملية عملية عبعض الحالات و
+
+552
+00:36:31,370 --> 00:36:33,510
+ليس دائمًا انظر إلى ال .. على سبيل المثال هنا
+
+553
+00:36:33,510 --> 00:36:39,190
+اتفاق الانديان تحدد بعض الطرق .. بعض الطرق التي
+
+554
+00:36:39,190 --> 00:36:42,630
+نستطيع ان ننتهي منها او الagency يمكن ان يتم
+
+555
+00:36:42,630 --> 00:36:47,610
+إخلاصها رقم واحد هو .. رقم واحد اذا عملية الagency
+
+556
+00:36:47,610 --> 00:36:55,430
+تم إكمالها بسهولة تعطي جايدا خمس PC's هي عملي و هي
+
+557
+00:36:55,430 --> 00:37:00,500
+تريد أن تأخذه و تسحبها في السوقshe completed the
+
+558
+00:37:00,500 --> 00:37:03,240
+job she sold the computers and she got the money
+
+559
+00:37:03,240 --> 00:37:07,000
+and she got the commission job is completed job is
+
+560
+00:37:07,000 --> 00:37:13,460
+done job is well done then the agency is completed
+
+561
+00:37:13,460 --> 00:37:17,140
+completed it's terminated automatically that's
+
+562
+00:37:17,140 --> 00:37:20,500
+number one number two agent number two the agent
+
+563
+00:37:20,500 --> 00:37:25,880
+can renounce the business of the agents renounce
+
+564
+00:37:25,880 --> 00:37:30,090
+يتخلان he does not want to work anymorehe can give
+
+565
+00:37:30,090 --> 00:37:34,550
+up he can leave it I cannot just keep that person
+
+566
+00:37:34,550 --> 00:37:37,790
+for more time if he does not want to work for me
+
+567
+00:37:37,790 --> 00:37:47,010
+number four okay
+
+568
+00:37:47,010 --> 00:37:53,950
+but
+
+569
+00:37:53,950 --> 00:37:56,470
+suddenly the agent doesn't want to work what can I
+
+570
+00:37:56,470 --> 00:38:02,980
+doI might get some compensation out of him I'm ..
+
+571
+00:38:02,980 --> 00:38:06,260
+we have to look .. we look at this later on in the
+
+572
+00:38:06,260 --> 00:38:09,060
+next slide we will see in which situation we
+
+573
+00:38:09,060 --> 00:38:13,820
+cannot terminate in general we say you have the
+
+574
+00:38:13,820 --> 00:38:16,200
+freedom you can end it you can renounce you can
+
+575
+00:38:16,200 --> 00:38:20,820
+revoke the agents here like principal can revoke
+
+576
+00:38:20,820 --> 00:38:28,340
+يبطل يلغي cancelcan cancel the contract the time
+
+577
+00:38:28,340 --> 00:38:33,540
+he or she like and number three if the principal
+
+578
+00:38:33,540 --> 00:38:36,300
+being adjudicated what's adjudicated do you know
+
+579
+00:38:36,300 --> 00:38:43,560
+it adjudicated حكم عليه يعني if he was adjudicated
+
+580
+00:38:43,560 --> 00:38:50,120
+insolvent if he or she becomes bankrupt مفلس then
+
+581
+00:38:50,120 --> 00:38:55,640
+if that if the principal becomes bankrupt او او او
+
+582
+00:38:55,640 --> 00:38:56,000
+او او او او او او او او او او او او او او او او او
+
+583
+00:38:56,000 --> 00:38:56,000
+او او او او او او او او او او او او او او او او او
+
+584
+00:38:56,000 --> 00:38:56,000
+او او او او او او او او او او او او او او او او او
+
+585
+00:38:56,000 --> 00:38:56,000
+او او او او او او او او او او او او او او او او او
+
+586
+00:38:56,000 --> 00:38:59,370
+او او او او او او او او اوفهو لا يستطيع أن يدفع
+
+587
+00:38:59,370 --> 00:39:02,010
+المال فهو لا يستطيع أن يكون رئيس فهو لا يستطيع أن
+
+588
+00:39:02,010 --> 00:39:07,170
+يقوم بنفسه فهنا لا يوجد مسؤولية هنا فإن المجلدية
+
+589
+00:39:07,170 --> 00:39:15,090
+تمت اطمانيا هذا بشكل عام ولكن في بعض الحالات يجب
+
+590
+00:39:15,090 --> 00:39:20,830
+أن تبحث عنها بحذف بعض الحالات لا نستطيع أن ندفع
+
+591
+00:39:20,830 --> 00:39:24,920
+المال في المجلديةas a principal I cannot come to
+
+592
+00:39:24,920 --> 00:39:27,080
+you and say well come on listen I'm gonna
+
+593
+00:39:27,080 --> 00:39:30,720
+terminate your agency today it's not my option
+
+594
+00:39:30,720 --> 00:39:34,720
+it's not my choice I cannot do it if I do it I
+
+595
+00:39:34,720 --> 00:39:37,240
+would have to compensate you I would have to pay
+
+596
+00:39:37,240 --> 00:39:42,180
+you money one of the cases it's called here this
+
+597
+00:39:42,180 --> 00:39:45,760
+was a question in the exam before many times it's
+
+598
+00:39:45,760 --> 00:39:50,450
+agency coupled with interestsعندما يكون لديك سؤال
+
+599
+00:39:50,450 --> 00:39:55,350
+مثل هذا فقط تحدث عنه ماذا يعني ذلك؟ كيف يمكنك أن
+
+600
+00:39:55,350 --> 00:39:59,610
+تدفعه؟ agency coupled with interest في هذه الحالة
+
+601
+00:39:59,610 --> 00:40:02,030
+إذا كان لدينا agency coupled with interest
+
+602
+00:40:02,030 --> 00:40:05,370
+فالأسلوب لا يمكن أن يقوم بتحريره لا يمكن أن يتهيأ
+
+603
+00:40:05,370 --> 00:40:08,910
+به لا يمكن أن يتمكن أن يتهيأ به حسنا، ماذا يعني
+
+604
+00:40:08,910 --> 00:40:14,750
+ذلك؟ ماذا يعني agency coupled with interest؟ انها
+
+605
+00:40:14,750 --> 00:40:18,010
+coupled with interest of the agent in the subject
+
+606
+00:40:18,010 --> 00:40:22,640
+matter of agencyI need to give an example to
+
+607
+00:40:22,640 --> 00:40:27,360
+explain it more agency coupled with coupled with
+
+608
+00:40:27,360 --> 00:40:32,180
+يعني ممزوجة مع with interest مصلحة of the agents
+
+609
+00:40:32,180 --> 00:40:38,180
+in the subject matter example an example of this
+
+610
+00:40:38,180 --> 00:40:47,620
+like having 50 PCs 50 laptops 50 laptops and I
+
+611
+00:40:47,620 --> 00:40:55,820
+gave them toعشان اوى 50 لابتوب عشان اتخذها لمركزها
+
+612
+00:40:55,820 --> 00:41:00,680
+و لعبتها كل ما تريده ان تفعله هو ان تبيعها اعطيك
+
+613
+00:41:00,680 --> 00:41:02,920
+الاصطناع ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي
+
+614
+00:41:02,920 --> 00:41:02,920
+ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي
+
+615
+00:41:02,920 --> 00:41:05,000
+ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي
+
+616
+00:41:05,000 --> 00:41:07,460
+ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي
+
+617
+00:41:07,460 --> 00:41:09,620
+ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي
+
+618
+00:41:09,620 --> 00:41:09,620
+ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي
+
+619
+00:41:09,620 --> 00:41:09,640
+ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي ابيبي
+
+620
+00:41:09,640 --> 00:41:12,620
+ابي
+
+621
+00:41:22,090 --> 00:41:24,290
+الموضوع نفسه .. how can we sell .. can you sell
+
+622
+00:41:24,290 --> 00:41:29,960
+them in one day .. maybe .. maybe notلنقول انها
+
+623
+00:41:29,960 --> 00:41:33,360
+كانت تعمل ل2 او 3 أسابيع تحاول أن تبيعهم ولكنها
+
+624
+00:41:33,360 --> 00:41:37,040
+قامت ببيع بعض منهم ولكنها لم تكمل في ذلك الوقت هل
+
+625
+00:41:37,040 --> 00:41:40,020
+يمكنني أن أقول له يا عزيزي هيا العمل قد انتهى أنا
+
+626
+00:41:40,020 --> 00:41:43,680
+لا أريدك أن تعمل لأني بعد الأن؟ لا يعمل، لا يعمل
+
+627
+00:41:43,680 --> 00:41:48,580
+هكذا، يجب أن تكمل هذا العمل، يجب أن تنهيه، لماذا؟
+
+628
+00:41:48,580 --> 00:41:53,590
+لأن في هذه الحالة، لن تحصل على المالunless she
+
+629
+00:41:53,590 --> 00:41:58,550
+sells all the items it can be sometimes many items
+
+630
+00:41:58,550 --> 00:42:03,630
+sometimes can be one item one item one thing one
+
+631
+00:42:03,630 --> 00:42:06,030
+transaction it can be sometimes one transaction
+
+632
+00:42:06,030 --> 00:42:09,090
+which cost millions maybe hundreds of thousands of
+
+633
+00:42:09,090 --> 00:42:13,130
+pounds then that person will get the money out of
+
+634
+00:42:13,130 --> 00:42:15,210
+the subject matter can just can you read this for
+
+635
+00:42:15,210 --> 00:42:15,950
+me جيدا
+
+636
+00:42:23,040 --> 00:42:26,700
+the goods were consigned .. consigned تم تحديده
+
+637
+00:42:26,700 --> 00:42:31,060
+for the agent to sale .. for sale to recoup ..
+
+638
+00:42:31,060 --> 00:42:35,260
+recoup to get his money .. recoup يستغد .. يأخد ..
+
+639
+00:42:35,260 --> 00:42:40,860
+يدفع himself from the sale proceeds we consigned
+
+640
+00:42:40,860 --> 00:42:44,800
+.. هي .. when the goods are consigned consigned
+
+641
+00:42:44,800 --> 00:42:48,400
+حددنا .. these goods take them sell and then you
+
+642
+00:42:48,400 --> 00:42:52,840
+recoup .. recoup yourself .. recoupتستريد و يدفع
+
+643
+00:42:52,840 --> 00:42:57,040
+لنفسه himself from the sale proceeds .. proceeds
+
+644
+00:42:57,040 --> 00:43:01,760
+.. اوه اوه اوه
+
+645
+00:43:01,760 --> 00:43:01,800
+اوه اوه اوه اوه اوه اوه اوه اوه اوه اوه اوه اوه
+
+646
+00:43:01,800 --> 00:43:01,960
+اوه اوه اوه اوه اوه اوه اوه اوه اوه اوه اوه اوه
+
+647
+00:43:01,960 --> 00:43:01,960
+اوه اوه اوه اوه اوه اوه اوه اوه اوه اوه اوه اوه
+
+648
+00:43:01,960 --> 00:43:01,960
+اوه اوه اوه اوه اوه اوه اوه اوه اوه اوه اوه اوه
+
+649
+00:43:01,960 --> 00:43:01,960
+اوه اوه اوه اوه اوه اوه اوه اوه اوه اوه اوه اوه
+
+650
+00:43:01,960 --> 00:43:17,360
+اوه اوه اوه اوه او
+
+651
+00:43:20,930 --> 00:43:24,210
+نعم في بعض الحالات .. نعم يمكن أن يكون .. مثلا انا
+
+652
+00:43:24,210 --> 00:43:28,570
+.. انا سأنظر إلى الوضع بعد ان اتغيرت عقلي .. انها
+
+653
+00:43:28,570 --> 00:43:32,110
+ممكنة لأنك لديك الحرية هنا .. انها ممكنة .. عادة
+
+654
+00:43:32,110 --> 00:43:35,310
+في هذه الحالة في أساسيات عامة .. لا يمكنك ان تنتهي
+
+655
+00:43:35,310 --> 00:43:38,850
+منها .. لكن اذا اقسم وانا انتهي من الوظيفة التي
+
+656
+00:43:38,850 --> 00:43:42,170
+مرتبطة بالإهتمام .. في هذه الحالة يجب أن اعوض
+
+657
+00:43:42,170 --> 00:43:49,920
+وظيفتي كإذا كان يجب أن يخرج من السوقأحيانًا أعطي
+
+658
+00:43:49,920 --> 00:43:53,400
+هذا الكمبيوتر لأخبره أنه عندما تبيعهم فإن عملياتك
+
+659
+00:43:53,400 --> 00:44:03,240
+5% او 10% ثم سأخبره كم عمليات الكمبيوتر و كم
+
+660
+00:44:03,240 --> 00:44:05,280
+عمليات الكمبيوتر و كم عمليات الكمبيوتر و كم عمليات
+
+661
+00:44:05,280 --> 00:44:05,440
+الكمبيوتر و كم عمليات الكمبيوتر و كم عمليات
+
+662
+00:44:05,440 --> 00:44:05,740
+الكمبيوتر و كم عمليات الكمبيوتر و كم عمليات
+
+663
+00:44:05,740 --> 00:44:07,660
+الكمبيوتر و كم عمليات الكمبيوتر و كم عمليات
+
+664
+00:44:07,660 --> 00:44:08,080
+الكمبيوتر و كم عمليات الكمبيوتر و كم عمليات
+
+665
+00:44:08,080 --> 00:44:09,740
+الكمبيوتر و كم عمليات الكمبيوتر و كم عمليات
+
+666
+00:44:09,740 --> 00:44:13,260
+الكمبيوتر و
+
+667
+00:44:13,260 --> 00:44:13,260
+كم عمليات
+
+668
+00:44:17,490 --> 00:44:23,990
+الثاني حالة .. حتى قبل حالة ثانية هنا .. حتى مثل
+
+669
+00:44:23,990 --> 00:44:26,130
+مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل
+
+670
+00:44:26,130 --> 00:44:26,410
+مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل
+
+671
+00:44:26,410 --> 00:44:26,770
+مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل
+
+672
+00:44:26,770 --> 00:44:28,870
+مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل
+
+673
+00:44:28,870 --> 00:44:28,870
+مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل
+
+674
+00:44:28,870 --> 00:44:28,950
+مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل
+
+675
+00:44:28,950 --> 00:44:28,950
+مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل
+
+676
+00:44:28,950 --> 00:44:28,950
+مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل مثل
+
+677
+00:44:28,950 --> 00:44:28,950
+مثل مثل مثل مثل
+
+678
+00:44:36,000 --> 00:44:39,460
+كل ما كان يجب عليه فعله انا لن استطيع توقفه فقط
+
+679
+00:44:39,460 --> 00:44:43,140
+اتركه اترك الوظيفة لتكمل عمله عمله عمله عمله عمله
+
+680
+00:44:43,140 --> 00:44:43,520
+عمله عمله عمله عمله عمله عمله عمله عمله عمله عمله
+
+681
+00:44:43,520 --> 00:44:46,360
+عمله عملى عملى عملى عملى عملى عملى عملى عملى عملى
+
+682
+00:44:46,360 --> 00:44:46,580
+عملى عملى عملى عملى عملى عملى عملى عملى عملى عملى
+
+683
+00:44:46,580 --> 00:44:46,840
+عملى عملى عملى عملى عملى عملى عملى عملى عملى عملى
+
+684
+00:44:46,840 --> 00:44:47,440
+عملى عملى عملى عملى عملى عملى عملى عملى عملى عملى
+
+685
+00:44:47,440 --> 00:44:50,600
+عملى عملى عملى
+
+686
+00:44:50,600 --> 00:44:57,380
+عملى عملى عملى
+
+687
+00:44:57,380 --> 00:45:00,840
+عم
+
+688
+00:45:05,700 --> 00:45:13,940
+fixed period time limit six months two years fixed
+
+689
+00:45:13,940 --> 00:45:17,620
+time fixed period we specify the time exactly how
+
+690
+00:45:17,620 --> 00:45:19,560
+long you're going to be working for me as an agent
+
+691
+00:45:19,560 --> 00:45:24,320
+okay let's say if the agency was for one year one
+
+692
+00:45:24,320 --> 00:45:31,280
+year can i as a principal terminate the agency
+
+693
+00:45:31,280 --> 00:45:33,220
+before the one year is completed
+
+694
+00:45:35,980 --> 00:45:46,080
+لا يمكن الوظيفة أن تنسى وظيفته؟ الإجابة بسيطة هي
+
+695
+00:45:46,080 --> 00:45:52,400
+لا لأن إذا كان لدينا وظيفة أو شخص مصطلح و وظيفةفى
+
+696
+00:45:52,400 --> 00:45:57,740
+مقرر وقت مقرر فى مقرر وقت مقرر فى مقرر فى مقرر فى
+
+697
+00:45:57,740 --> 00:46:09,040
+مقرر فى مقرر فى مقرر فى مقرر فى مقرر فى مقرر فى
+
+698
+00:46:09,040 --> 00:46:09,600
+مقرر فى مقرر فى مقرر فى مقرر فى مقرر فى مقرر فى
+
+699
+00:46:09,600 --> 00:46:09,600
+مقرر فى مقرر فى مقرر فى مقرر فى مقرر فى مقرر فى
+
+700
+00:46:09,600 --> 00:46:09,600
+مقرر فى مقرر فى مقرر فى مقرر فى مقرر فى مقرر فى
+
+701
+00:46:09,600 --> 00:46:16,360
+مقرر فى مقرر فى مقرر فى مقرر فى مقرر فى مقرر فى
+
+702
+00:46:16,360 --> 00:46:22,540
+مقرر فىبنسبة للقوة أو الرئيس الذي لا يستطيع أن
+
+703
+00:46:22,540 --> 00:46:25,820
+يحتوي عمله و لا يستطيع أن يجد أحد أخر يفعل نفس
+
+704
+00:46:25,820 --> 00:46:31,240
+العمل و أحيانًا يمكن أن يكون المنافسة أن الشركة
+
+705
+00:46:31,240 --> 00:46:36,500
+فقط فجأة الرئيس يطلب منه أن يرحل ماذا يمكن أن
+
+706
+00:46:36,500 --> 00:46:42,340
+يفعل؟ يعرف أنه رحل بعض العمل لهذا الشخص لم يقبل
+
+707
+00:46:42,340 --> 00:46:48,440
+واحد عرض في شركة واحدة لكي تكون شركة لهذا الرئيسثم
+
+708
+00:46:48,440 --> 00:46:52,000
+يجب أن ننظر إلى هذه الحالة كمجلة كاملة واحد سنة هي
+
+709
+00:46:52,000 --> 00:46:56,280
+واحد سنة وقت مقرر هو وقت مقرر كلاهم يجب أن يبقوا
+
+710
+00:46:56,280 --> 00:47:05,040
+مجلدهم حتى نهاية الوقت إذا لم يكن لدينا سبب كافي
+
+711
+00:47:05,040 --> 00:47:11,040
+انا لا أستطيع أن أخلق مجلدي مجلدي إذا أشعر أن
+
+712
+00:47:11,040 --> 00:47:17,960
+مجلدي فعلت شيءوهو غير متواضع مع عملتي، شيء يمكن أن
+
+713
+00:47:17,960 --> 00:47:22,180
+يأثرني بشكل سيئ كمعاملة، شيء مثلًا هنا مثلًا، غير
+
+714
+00:47:22,180 --> 00:47:29,080
+مبادرة، غير مبادرة من أرادات قوية، يطلب .. يطلب من
+
+715
+00:47:29,080 --> 00:47:32,480
+مجلدي أن يفعل شيء، لكنه ينفذ، لذلك لماذا يجب أن
+
+716
+00:47:32,480 --> 00:47:35,980
+أدفع مالك كمجلدي، إذا لم تكن ممكن أن تفعل العمل
+
+717
+00:47:35,980 --> 00:47:39,440
+الذي أطلب منك أن تفعله، وهو حقيقي، وقد قرر في
+
+718
+00:47:39,440 --> 00:47:42,600
+التطبيقات، داخل التطبيقات والتواصلات، يجب أن
+
+719
+00:47:42,600 --> 00:47:46,780
+تتبعهايجب أن تكون مرتبطًا يجب أن تعمل على الرقم
+
+720
+00:47:46,780 --> 00:47:53,200
+كما أنك تتفاوض عن المجلد بينك وهو لذلك مسبوع كافي
+
+721
+00:47:53,200 --> 00:47:57,360
+ماذا أخرى؟ ماهو نوع المسبوع اللي يمكن أن يدفع
+
+722
+00:47:57,360 --> 00:48:05,780
+الرقم لإطلاق المجلد؟ لإطلاق المجلد؟ إن المجلد كان
+
+723
+00:48:05,780 --> 00:48:09,860
+حقًا .. إنك لم تتوقف عن الرقم أو أنك لم تستخدم
+
+724
+00:48:09,860 --> 00:48:15,970
+المجلدyes if if his behavior was not nice to the
+
+725
+00:48:15,970 --> 00:48:19,350
+customers and you know sometimes not sometimes
+
+726
+00:48:19,350 --> 00:48:23,250
+most of the time now without customers service you
+
+727
+00:48:23,250 --> 00:48:26,370
+cannot work you have to look after the customers
+
+728
+00:48:26,370 --> 00:48:29,650
+there is something called customer service you
+
+729
+00:48:29,650 --> 00:48:31,630
+have to keep those customers you have to deal with
+
+730
+00:48:31,630 --> 00:48:35,900
+them in a nice way in a gentle waythen if the
+
+731
+00:48:35,900 --> 00:48:39,460
+agent is dealing with them in a very bad behavior
+
+732
+00:48:39,460 --> 00:48:42,520
+it means that we're losing the customers day after
+
+733
+00:48:42,520 --> 00:48:46,600
+day then it's the right for the principal to ask
+
+734
+00:48:46,600 --> 00:48:48,960
+the agent to leave it's the right for the
+
+735
+00:48:48,960 --> 00:48:54,080
+principal to renounce يعني ممكن يلغي to cancel the
+
+736
+00:48:54,080 --> 00:48:58,520
+agency and and you can like you can have other
+
+737
+00:48:58,520 --> 00:49:01,060
+situations you can have other situations looking
+
+738
+00:49:01,060 --> 00:49:04,190
+like this situationit's not only these reasons
+
+739
+00:49:04,190 --> 00:49:07,170
+anything and it's sufficient or sufficient
+
+740
+00:49:07,170 --> 00:49:10,570
+sufficient
+
+741
+00:49:10,570 --> 00:49:18,490
+reason يعني سبب كافي سبب مقنع sufficient reason in
+
+742
+00:49:18,490 --> 00:49:20,830
+any case in this situation here if it's a fixed
+
+743
+00:49:20,830 --> 00:49:25,790
+period agency you have to give notice notice
+
+744
+00:49:25,790 --> 00:49:28,810
+notice it most likely will be like a few weeks
+
+745
+00:49:28,810 --> 00:49:34,720
+four weeks more or lessوحتى لو كان عليك تجارب ذلك
+
+746
+00:49:34,720 --> 00:49:40,060
+الشخص إذا كان التجارب مقررة لسنة أو ست أشهر أو خمس
+
+747
+00:49:40,060 --> 00:49:43,080
+سنة أو خمس سنة أو خمس سنة أو خمس سنة او خمس سنة او
+
+748
+00:49:43,080 --> 00:49:44,320
+خمس سنة او خمس سنة او خمس سنة او خمس سنة او خمس
+
+749
+00:49:44,320 --> 00:49:44,400
+سنة او خمس سنة او خمس سنة او خمس سنة او خمس سنة او
+
+750
+00:49:44,400 --> 00:49:46,660
+خمس سنة او خمس سنتين او خمس سنتين او خمس سنتين او
+
+751
+00:49:46,660 --> 00:49:53,460
+خمس سنتين او خمس سنتين او خمس سنتين او خمس سنتين
+
+752
+00:49:53,460 --> 00:49:58,440
+او خمس سنتين او خمس
+
+753
+00:49:59,580 --> 00:50:02,300
+I will need a compensation you have to pay me for
+
+754
+00:50:02,300 --> 00:50:05,120
+the whole period of time in all cases you have to
+
+755
+00:50:05,120 --> 00:50:08,960
+give notice given by one party to the other
+
+756
+00:50:08,960 --> 00:50:16,420
+whether they a or p principal agent it is a
+
+757
+00:50:16,420 --> 00:50:18,340
+warning you cannot leave now like you know leaving
+
+758
+00:50:18,340 --> 00:50:22,440
+me now as an agent leaving the principal you
+
+759
+00:50:22,440 --> 00:50:25,560
+cannot just close the shop because how much money
+
+760
+00:50:25,560 --> 00:50:30,320
+I'm gonna loseبسبب أنك قد عشت .. اعطيه وقت فقط ..
+
+761
+00:50:30,320 --> 00:50:34,580
+اعطيه وقت لعدة أسابيع و اخبرك ماذا .. أكتر ممكن ..
+
+762
+00:50:34,580 --> 00:50:41,020
+أكتر ممكن أن هذه المقالات تكون مكتوبة في مؤسسة كم
+
+763
+00:50:41,020 --> 00:50:44,880
+وقت أستطيع أن أعطيه لإخباره .. كم وقت ممكن أن تكون
+
+764
+00:50:44,880 --> 00:50:48,300
+مؤسسة لها .. كم مال ممكن أن نكون محافظين عليه ..
+
+765
+00:50:48,300 --> 00:50:53,520
+كل شيء يمكن أن يكون مصطلح في مؤسسة .. بين الرئيس
+
+766
+00:50:53,520 --> 00:50:56,180
+ومؤسسة .. إذا لم يكن مصطلح .. ماذا .. ماذا يمكننا
+
+767
+00:50:56,180 --> 00:51:00,780
+فعل؟if there is nothing .. nothing was stated in
+
+768
+00:51:00,780 --> 00:51:05,840
+the agency anyone else can answer .. come on think
+
+769
+00:51:05,840 --> 00:51:08,800
+about it a little bit it's just logic it's common
+
+770
+00:51:08,800 --> 00:51:17,960
+sense anyone here .. there .. no excellent
+
+771
+00:51:17,960 --> 00:51:18,700
+that's it
+
+772
+00:51:27,700 --> 00:51:30,160
+ممكن تتحدث عن ذلك، ممكن تتحدث عن ذلك بين رئيس و
+
+773
+00:51:30,160 --> 00:51:34,220
+مجلد إذا لم يتمكنوا من الوصول إلى اتفاق، يمكنهم
+
+774
+00:51:34,220 --> 00:51:38,700
+الذهاب إلى القاضة يمكنهم الذهاب إلى الانتصاف أو
+
+775
+00:51:38,700 --> 00:51:44,860
+الانتصاف عندما يتمكن التقرير من تأثير .. وهذا لم
+
+776
+00:51:44,860 --> 00:51:50,780
+يكن سؤال من قبل عندما يتمكن التقرير من تأثير .. في
+
+777
+00:51:50,780 --> 00:51:57,280
+الوقت عندما .. عندما المجلد يعرف عنهإذا كنت سأنهي
+
+778
+00:51:57,280 --> 00:52:04,700
+مجلدي مجلدي، فسأخبره أن المجلد قد انتهى، لا يمكنك
+
+779
+00:52:04,700 --> 00:52:10,180
+أن تعمل لدي بعد الأن، لذلك عندما يعرف المجلد عن
+
+780
+00:52:10,180 --> 00:52:16,990
+الأمر، عندما يصبح المجلد معروف لهو للمستخدمين
+
+781
+00:52:16,990 --> 00:52:21,350
+الثالثة هي أن الagency قد انتهى عندما يعرفوا عنها
+
+782
+00:52:21,350 --> 00:52:25,770
+إنها عن إخبار الناس بإخبارهم أن ال agency قد
+
+783
+00:52:25,770 --> 00:52:29,330
+انتهى، احذر يا عيال، يمكنك أن تكون هناك سؤال صح أو
+
+784
+00:52:29,330 --> 00:52:35,510
+خاطئ، الكثير من الطلاب يخلصوا و لا يعرفون الإجابة
+
+785
+00:52:35,510 --> 00:52:38,970
+و
+
+786
+00:52:38,970 --> 00:52:42,110
+حتى ال termination ال agency يمكن أن يكون بعض
+
+787
+00:52:42,110 --> 00:52:46,890
+الأحيان بكلمات مفهومةexplicit ways or implicit
+
+788
+00:52:46,890 --> 00:52:51,810
+ways explicit or implicit by both ways like we
+
+789
+00:52:51,810 --> 00:52:54,050
+said at the beginning come on we said what did we
+
+790
+00:52:54,050 --> 00:52:58,250
+say i can make an agency or somebody factual
+
+791
+00:52:58,250 --> 00:53:02,150
+actual agency apparent by position so it's by
+
+792
+00:53:02,150 --> 00:53:07,570
+explicit or by implicit actions you can terminate
+
+793
+00:53:07,570 --> 00:53:11,350
+the agency the same way we have granted it
+
+794
+00:53:17,020 --> 00:53:20,700
+أخر ثلاثة صفحات هنا واحدة منها هي agency و
+
+795
+00:53:20,700 --> 00:53:24,700
+partnership أخر مرة قمت بالشرح في هذا النقطة
+
+796
+00:53:24,700 --> 00:53:35,300
+agency
+
+797
+00:53:35,300 --> 00:53:39,800
+و partnership partnership
+
+798
+00:53:39,800 --> 00:53:44,200
+هي شركة صغيرة ، شركة صغيرة جدًا يمكن أن تكون من
+
+799
+00:53:44,200 --> 00:53:48,060
+اتين أشخاص أو أكتر من اتين أشخاصهو اتصال اتصال
+
+800
+00:53:48,060 --> 00:53:50,820
+اتصال اتصال اتصال اتصال اتصال اتصال اتصال اتصال
+
+801
+00:53:50,820 --> 00:53:52,280
+اتصال اتصال اتصال اتصال اتصال اتصال اتصال اتصال
+
+802
+00:53:52,280 --> 00:53:54,400
+اتصال اتصال اتصال اتصال اتصال اتصال اتصال اتصال
+
+803
+00:53:54,400 --> 00:53:55,340
+اتصال اتصال اتصال اتصال اتصال اتصال اتصال اتصال
+
+804
+00:53:55,340 --> 00:53:58,140
+اتصال اتصال اتصال اتصال اتصال اتصال اتصال اتصال
+
+805
+00:53:58,140 --> 00:53:58,140
+اتصال اتصال اتصال اتصال اتصال اتصال اتصال اتصال
+
+806
+00:53:58,140 --> 00:54:15,860
+اتصال اتصال اتصال اتصال اتصال ات
+
+807
+00:54:16,670 --> 00:54:21,410
+is an agent for all of us we have some scholars
+
+808
+00:54:21,410 --> 00:54:26,370
+like in in English law in English law it says that
+
+809
+00:54:26,370 --> 00:54:33,870
+partner everyone is an agent for other partners so
+
+810
+00:54:33,870 --> 00:54:40,850
+a is an agent for a b c and dكل واحد هو مجلد
+
+811
+00:54:40,850 --> 00:54:46,770
+للمشاركات والسقوطية تقول لا ليس كذلك جميعهم يكونوا
+
+812
+00:54:46,770 --> 00:54:50,330
+مجلد للمجلد للمشاركات جميعهم
+
+813
+00:54:50,330 --> 00:54:57,050
+يكونوا مجلد
+
+814
+00:54:57,050 --> 00:54:59,990
+للمشاركات
+
+815
+00:55:00,410 --> 00:55:03,430
+في الحياة الواقعية لا يجعلها مختلفة، إنها نفس
+
+816
+00:55:03,430 --> 00:55:07,030
+الشيء، نفس الشيء، ماذا يعني أنها نفس الشيء؟ هذا
+
+817
+00:55:07,030 --> 00:55:10,690
+يعني أن إذا كان شركة تعمل اتفاقية أو اتفاقية مع
+
+818
+00:55:10,690 --> 00:55:16,170
+المستخدمين، فهو أو هي ستجمعهم جميعًا، دعنا نقول
+
+819
+00:55:16,170 --> 00:55:22,410
+أننا لدينا A, B, C, D، أربع أصحاب، واحدة تعمل من 8
+
+820
+00:55:22,410 --> 00:55:27,150
+في الصباح إلى 12 في الظهر، وكذلك وكذلك، أربع
+
+821
+00:55:27,150 --> 00:55:31,340
+تحويل، أو واحدة منهم يعمل في weekend،إذا واحد
+
+822
+00:55:31,340 --> 00:55:36,540
+منهم، واحد من المشاركين، كمشارك لكم جميعًا، قام
+
+823
+00:55:36,540 --> 00:55:41,260
+بتجارب، هذه التجارب ستقوم بتجارب الجميع من
+
+824
+00:55:41,260 --> 00:55:46,660
+المشاركين، كلهم يجب أن يكونوا مقابلين، ننظر إلى
+
+825
+00:55:46,660 --> 00:55:51,540
+المقابلة، حتى لو كان المشارك كان مخاطرًا كمشارك،
+
+826
+00:55:51,540 --> 00:55:54,660
+حتى لو كان يعمل بسرعة
+
+827
+00:55:57,450 --> 00:56:02,210
+هي مسؤلتنا، لدينا أربع أو خمس اشخاص كمشاركين، نثق
+
+828
+00:56:02,210 --> 00:56:05,690
+ببعضنا البعض، لدينا اتصال جيد، نعرف بعضنا البعض
+
+829
+00:56:05,690 --> 00:56:09,590
+بشكل جيد، ففي هذه الوضع هنا، فأي واحد مننا هو
+
+830
+00:56:09,590 --> 00:56:16,690
+مشارك، ومشارك، ويجب أن نكون مخاطرين جميعنا، لذلك
+
+831
+00:56:16,690 --> 00:56:21,730
+يمكن المستخدمين أن يقومواأي واحد منهم a b c d او
+
+832
+00:56:21,730 --> 00:56:26,390
+اي شخص حتى لو كان لديه خمسين و الوظيفة تستطيع
+
+833
+00:56:26,390 --> 00:56:32,170
+تجارب جميعهم جمعًا لعبادة او لعبادات مختلفة تستطيع
+
+834
+00:56:32,170 --> 00:56:34,610
+اختيار اي واحد منهم تستطيع تجارب اي واحد منهم انه
+
+835
+00:56:34,610 --> 00:56:36,770
+يتعامل معك انه يتعامل مع الوظيفة تستطيع تجارب اي
+
+836
+00:56:36,770 --> 00:56:41,850
+واحد منهم تستطيع تجارب اي واحد منهم تستطيع تجارب
+
+837
+00:56:41,850 --> 00:56:43,990
+اي واحد منهم تستطيع تجارب اي واحد منهم تستطيع
+
+838
+00:56:43,990 --> 00:56:45,330
+تجارب اي واحد منهم تستطيع تجارب اي واحد منهم
+
+839
+00:56:45,330 --> 00:56:47,880
+تستطيع تجارب اي واحد منهم تستطيع تجارب اطبعا في
+
+840
+00:56:47,880 --> 00:56:52,080
+نهاية اليوم .. اذا .. دعنا نقول ان واحد منهم C ..
+
+841
+00:56:52,080 --> 00:56:56,120
+C لديه مجال لزيارة المستخدم .. لقد أعطاه الكثير من
+
+842
+00:56:56,120 --> 00:57:01,080
+المال .. ثم C يستطيع أن يعود إلى A, B وD .. هيا ..
+
+843
+00:57:01,080 --> 00:57:03,700
+انها عملنا .. عليك أن تدفعه لذلك .. اعني هو سيعود
+
+844
+00:57:03,700 --> 00:57:08,380
+لهم ليحصل .. ليحصل على حقه .. لأنها شارة متساومة
+
+845
+00:57:08,380 --> 00:57:11,960
+.. أكثر من .. حتى لو لم تكن شارة متساومة .. فكل
+
+846
+00:57:11,960 --> 00:57:15,700
+واحد يدفع .. يعتمد على كم مال يدفع .. يعتمد على
+
+847
+00:57:15,700 --> 00:57:19,790
+الشارة .. على الشارة ..هناك شيء يسمى نotice of
+
+848
+00:57:19,790 --> 00:57:26,110
+limitation إذا كان واحد من المشاركين لديه قوة قوة
+
+849
+00:57:26,110 --> 00:57:29,450
+قوة قوة قوة قوة قوة قوة قوة قوة قوة قوة قوة قوة
+
+850
+00:57:29,450 --> 00:57:31,050
+قوة قوة قوة قوة قوة قوة قوة قوة قوة قوة قوة قوة
+
+851
+00:57:31,050 --> 00:57:31,130
+قوة قوة قوة قوة قوة قوة قوة قوة قوة قوة قوة قوة
+
+852
+00:57:31,130 --> 00:57:31,210
+قوة قوة قوة قوة قوة قوة قوة قوة قوة قوة قوة قوة
+
+853
+00:57:31,210 --> 00:57:31,210
+قوة قوة قوة قوة قوة قوة قوة قوة قوة قوة قوة قوة
+
+854
+00:57:31,210 --> 00:57:47,670
+قوة قوة قوة قو
+
+855
+00:57:50,760 --> 00:57:56,140
+لأحدهم دعونا نقول ان بي بي لديه قوة محددة و هو
+
+856
+00:57:56,140 --> 00:58:03,480
+مقدر يجعل أي تجارب أقل من 200 رمز اي تجارب أكتر من
+
+857
+00:58:03,480 --> 00:58:07,480
+200 رمز هو ليس من المفروض أن يعرفه لذلك هو ليس
+
+858
+00:58:07,480 --> 00:58:10,920
+مقدر يجعل اي تجارب اكتر من 200 رمز هو ليس مقدر
+
+859
+00:58:10,920 --> 00:58:14,790
+يجعل اي تجاربلأي عملية تجارب أقل من 200 ريال دولار
+
+860
+00:58:14,790 --> 00:58:24,170
+وهو الموظف لـ A , C و D كمعارفين للمستخدمين أن هذا
+
+861
+00:58:24,170 --> 00:58:28,530
+المستخدم هو مستخدم نعم ولكنه يمكن أن يعمل عملية
+
+862
+00:58:28,530 --> 00:58:34,010
+تجارب أقل من المال فهو ما يسمى بـ Notice of
+
+863
+00:58:34,010 --> 00:58:40,450
+Limitation هو الموظف الأول للمعارفين الأخرىإذا كان
+
+864
+00:58:40,450 --> 00:58:43,050
+واحد منهم .. واحد من المشاركين .. واحد من
+
+865
+00:58:43,050 --> 00:58:48,050
+المشاركين كان يعمل بشكل عظيم .. كان يخدع
+
+866
+00:58:48,050 --> 00:58:52,870
+المستخدمين .. كان يخدع .. كان يعمل مع إهمال ..
+
+867
+00:58:52,870 --> 00:58:57,530
+إهمال .. في هذه الحالة ، يمكن المستخدم الثالث أن
+
+868
+00:58:57,530 --> 00:59:02,150
+يعود لجميعهم ، ليس فقط .. ليس فقط لمشاركتهم ، لا ،
+
+869
+00:59:02,150 --> 00:59:05,510
+يمكنني أن أختار أن أرشدكم جميعًا كمستخدم ، إذا
+
+870
+00:59:05,510 --> 00:59:10,580
+كنتم جميعًا مشاركتينأنا مستخدم او ثالث مجتمع انا
+
+871
+00:59:10,580 --> 00:59:13,140
+استطيع انقذ كل المشاركين او انا استطيع انقذ واحد
+
+872
+00:59:13,140 --> 00:59:17,400
+حتى اذا لم يكن هو الشخص اللي قدره انقذه لا لان
+
+873
+00:59:17,400 --> 00:59:23,120
+لديك مسؤولية مشتركة مسؤولية مشتركة فهذا هو الحال
+
+874
+00:59:23,120 --> 00:59:27,760
+حتى هنا دعونا نرى اذا المشارك يعمل ضد اهتمامه
+
+875
+00:59:27,760 --> 00:59:33,000
+أحيانا يحدث ان واحد من المشاركين مجنون فهو يعمل ضد
+
+876
+00:59:33,000 --> 00:59:38,950
+اهتمام المشاركةهو فقط ممكن أن يكون مخططًا لجمهور
+
+877
+00:59:38,950 --> 00:59:44,690
+ثالث مجتمع يمكن أن يكون مخططًا بدفع المدفع يمكن أن
+
+878
+00:59:44,690 --> 00:59:51,690
+يدفع المستخدم الأخير يجب أن نقول إنه ليس في الكتاب
+
+879
+00:59:51,690 --> 00:59:55,990
+إنه فقط في المصطلح إنه في الكتاب أعتقد أنه نعم نعم
+
+880
+00:59:55,990 --> 01:00:02,890
+إنه شيء يسمى الـ brokeragemany people mix between
+
+881
+01:00:02,890 --> 01:00:06,950
+agency and brokerage yes many people mix between
+
+882
+01:00:06,950 --> 01:00:09,510
+them but in fact there is a whole difference
+
+883
+01:00:09,510 --> 01:00:14,230
+between them it's a big gap between brokerage and
+
+884
+01:00:14,230 --> 01:00:19,710
+agency what does it mean brokerage same students
+
+885
+01:00:19,710 --> 01:00:23,270
+come on here anyone in the back there only
+
+886
+01:00:29,410 --> 01:00:35,190
+ممكن أن يكون شخص عام يعمل اتفاق مع الشخص المتواصل
+
+887
+01:00:35,190 --> 01:00:40,530
+بين الشركة ومجتمعها ويعطيهم المساعدة والتعامل معها
+
+888
+01:00:40,530 --> 01:00:47,930
+ويكون مسؤول عن اي اتفاق مع مجموعة
+
+889
+01:00:47,930 --> 01:00:53,330
+الشركة التي تعمل التعامل معها ويعطيهم المساعدة
+
+890
+01:00:53,330 --> 01:00:58,750
+ويعطيهم المساعدةممتاز .. هذا جيد .. لذلك ليس مثل
+
+891
+01:00:58,750 --> 01:01:03,070
+مجلس البروكيريج .. إنه نوع من الهجوم .. إنه مجلس
+
+892
+01:01:03,070 --> 01:01:08,410
+القواعد التجارية .. لكن شخص يحاول الهجوم .. ليس
+
+893
+01:01:08,410 --> 01:01:12,050
+حتى هجوم .. شخص يحاول أن يحضر كلا الشركات مع بعض
+
+894
+01:01:12,050 --> 01:01:17,790
+.. شخص يحاول أن يحضر مجلس الإمبراطور مع بعض .. شخص
+
+895
+01:01:17,790 --> 01:01:18,650
+يحاول أن يحضر
+
+896
+01:01:23,970 --> 01:01:28,210
+الوصيد الوصيد السمصار
+
+897
+01:01:31,490 --> 01:01:38,230
+الان لدينا اختلاف بين البروكارات و البروكارات و
+
+898
+01:01:38,230 --> 01:01:47,690
+البروكارات و البروكارات و البروكارات و البروكارات
+
+899
+01:01:47,690 --> 01:01:55,330
+و البروكارات و البروكارات
+
+900
+01:01:58,510 --> 01:02:06,370
+في مؤسسات كما كنا ندرسها مؤسسة هي مجتمع مؤسسة هي
+
+901
+01:02:06,370 --> 01:02:08,930
+مجتمع مؤسسة يمكنها أن تقوم بإشتراك المعاملة يمكنها
+
+902
+01:02:08,930 --> 01:02:13,270
+أن تقوم بالتفكير يمكنها أن تقوم بإشتراك المعاملة
+
+903
+01:02:13,270 --> 01:02:14,170
+يمكنها أن تقوم بإشتراك المعاملة يمكنها أن تقوم
+
+904
+01:02:14,170 --> 01:02:14,310
+بإشتراك المعاملة يمكنها أن تقوم بإشتراك المعاملة
+
+905
+01:02:14,310 --> 01:02:14,830
+يمكنها أن تقوم بإشتراك المعاملة يمكنها أن تقوم
+
+906
+01:02:14,830 --> 01:02:15,530
+بإشتراك المعاملة يمكنها أن تقوم بإشتراك المعاملة
+
+907
+01:02:15,530 --> 01:02:18,930
+يمكنها أن تقوم بإشتراك المعاملة يمكنها أن تقوم
+
+908
+01:02:18,930 --> 01:02:23,730
+بإشتراك المعاملة يمكنالبروكر ليس مجتمعًا كل ما
+
+909
+01:02:23,730 --> 01:02:28,270
+يفعله او ماذا فعلها هو ان تجلب A وB معًا لتقرر شرح
+
+910
+01:02:28,270 --> 01:02:31,270
+شرح شرح شرح شرح شرح شرح شرح شرح شرح شرح شرح شرح
+
+911
+01:02:31,270 --> 01:02:32,250
+شرح شرح شرح شرح شرح شرح شرح شرح شرح شرح شرح شرح
+
+912
+01:02:32,250 --> 01:02:32,330
+شرح شرح شرح شرح شرح شرح شرح شرح شرح شرح شرح شرح
+
+913
+01:02:32,330 --> 01:02:35,170
+شرح شرح شرح شرح شرح شرح شرح شرح شرح شرح شرح شرح
+
+914
+01:02:35,170 --> 01:02:45,370
+شرح شرح شرح شرح شرح شرح شرح شرح شرح شرح شرح ش
+
+915
+01:02:50,650 --> 01:02:56,130
+أو أسبوعي أو أسبوعي يعتمد على اتفاقه يعتمد على
+
+916
+01:02:56,130 --> 01:02:59,610
+اتفاقه انه مثل .. انه مثل سلري لكن في البروكره انه
+
+917
+01:02:59,610 --> 01:03:00,950
+ليس كذلك انه ليس مجرد مجرد مجرد مجرد مجرد مجرد
+
+918
+01:03:00,950 --> 01:03:01,470
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+919
+01:03:01,470 --> 01:03:02,530
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+920
+01:03:02,530 --> 01:03:02,930
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+921
+01:03:02,930 --> 01:03:06,690
+مجرد مجرد مجرد مجرد
+
+922
+01:03:14,530 --> 01:03:18,170
+وهناك مثال مثل هذا في الكثير من المكان البروكر
+
+923
+01:03:18,170 --> 01:03:24,410
+يمكن ان يحضر فقط اتنين فرق مع بعض اتنين اتنين
+
+924
+01:03:24,410 --> 01:03:24,410
+اتنين اتنين اتنين اتنين اتنين اتنين اتنين اتنين
+
+925
+01:03:24,410 --> 01:03:25,270
+اتنين اتنين اتنين اتنين اتنين اتنين اتنين اتنين
+
+926
+01:03:25,270 --> 01:03:25,510
+اتنين اتنين اتنين اتنين اتنين اتنين اتنين اتنين
+
+927
+01:03:25,510 --> 01:03:25,510
+اتنين اتنين اتنين اتنين اتنين اتنين اتنين اتنين
+
+928
+01:03:25,510 --> 01:03:30,030
+اتنين اتنين اتنين اتنين اتنين اتنين اتنين اتنين
+
+929
+01:03:30,030 --> 01:03:41,050
+اتنين اتنين اتنين اتنين
+
+930
+01:03:44,480 --> 01:03:48,280
+الشركة تستطيع أن تقوم بتقرار و تقوم بتقرار و تقوم
+
+931
+01:03:48,280 --> 01:03:50,380
+بتقرار و تقرار و تقرار و تقرار و تقرار و تقرار و
+
+932
+01:03:50,380 --> 01:03:53,920
+تقرار و تقرار و تقرار و تقرار و تقرار و تقرار و
+
+933
+01:03:53,920 --> 01:03:54,240
+تقرار و تقرار و تقرار و تقرار و تقرار و تقرار و
+
+934
+01:03:54,240 --> 01:03:54,360
+تقرار و تقرار و تقرار و تقرار و تقرار و تقرار و
+
+935
+01:03:54,360 --> 01:03:54,900
+تقرار و تقرار و تقرار و تقرار و تقرار و تقرار و
+
+936
+01:03:54,900 --> 01:03:58,360
+تقرار و تقرار و تقرار و تقرار و تقرار و تقرار و
+
+937
+01:03:58,360 --> 01:04:04,400
+تقرار و تقرار و
+
+938
+01:04:04,400 --> 01:04:08,850
+تقرار و تهو يمكنه أن يقوم بإشتراك التجارة لكن ليس
+
+939
+01:04:08,850 --> 01:04:10,730
+الـ broker ال broker لا يمكنه أن يقوم بإشتراك
+
+940
+01:04:10,730 --> 01:04:11,850
+التجارة، لا يمكنه أن يقوم بإخلاء التجارة، لا يمكنه
+
+941
+01:04:11,850 --> 01:04:15,130
+أن يفعل أي شيء، فهو فقط .. أعني بطريقة عامة لا
+
+942
+01:04:15,130 --> 01:04:20,610
+يمكنه أن يتعامل مع ال .. مع المستخدم واحد من ال ..
+
+943
+01:04:20,610 --> 01:04:26,170
+واحد من أهم نقطة .. نقطة التي هي حقا مهمة هي
+
+944
+01:04:26,170 --> 01:04:33,130
+المخالفة نعرف أن الوظيفة مخالفة تجاه الرئيس و تجاه
+
+945
+01:04:33,130 --> 01:04:38,400
+المستخدم لكن ال broker ماذا تفكر؟he's not liable
+
+946
+01:04:38,400 --> 01:04:42,280
+broker is not liable once the contract is done or
+
+947
+01:04:42,280 --> 01:04:44,400
+even if it's not done it's not his liability he
+
+948
+01:04:44,400 --> 01:04:47,680
+doesn't care he just gets the money and just keep
+
+949
+01:04:47,680 --> 01:04:50,680
+doing the same business broker has no liability
+
+950
+01:04:50,680 --> 01:04:57,300
+okay thanks very much for your time thank you and
+
+951
+01:04:57,300 --> 01:05:01,480
+i'm gonna see you next week خلاص أنا
+
diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/PX2siF_3Hgs_raw.srt b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/PX2siF_3Hgs_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..0e13c68858735d91ccc009a9a7dad7e00a20ef28
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/PX2siF_3Hgs_raw.srt
@@ -0,0 +1,4008 @@
+1
+00:00:12,920 --> 00:00:17,280
+السلام عليكم و
+
+2
+00:00:17,280 --> 00:00:21,600
+اليوم سنحصل على حلقة أربعة هذه الحلقة أكتر من
+
+3
+00:00:21,600 --> 00:00:24,500
+الممكن أن ننتهي في وقت أسبوع او اتصالين
+
+4
+00:00:26,910 --> 00:00:31,750
+الشيء اللي لدينا هنا هو حوالي 15 أسلوب، هذا الحلقه
+
+5
+00:00:31,750 --> 00:00:36,470
+هي إمplementation من الحلقه الثالثة، ليس شيء جديد،
+
+6
+00:00:36,470 --> 00:00:39,290
+كان شيء كان لدينافي الأسبوع الماضيين الأسبوعين
+
+7
+00:00:39,290 --> 00:00:40,330
+الأسبوعين الأسبوعين الأسبوعين الأسبوعين أسبوعين
+
+8
+00:00:40,330 --> 00:00:41,050
+أسبوعين أسبوعين أسبوعين أسبوعين أسبوعين أسبوعين
+
+9
+00:00:41,050 --> 00:00:42,170
+أسبوعين أسبوعين أسبوعين أسبوعين أسبوعين أسبوعين
+
+10
+00:00:42,170 --> 00:00:46,490
+أسبوعين أسبوعين أسبوعين أسبوعين أسبوعين أسبوعين
+
+11
+00:00:46,490 --> 00:00:51,190
+أسبوعين
+
+12
+00:00:51,190 --> 00:00:52,570
+أسبوعين أسبوعين أسبوعين أسبوعين أسبوعين أسبوعين
+
+13
+00:00:52,570 --> 00:00:53,270
+أسبوعين أسبوعين أسبوعين أسبوعين أسبوعين أسبوعين
+
+14
+00:00:53,270 --> 00:00:53,270
+أسبوعين أسبوعين أسبوعين أسبوعين أسبوعين أسبوعين
+
+15
+00:00:53,270 --> 00:00:55,770
+أسبوعين أسبوعين أسبوعين أسبوعين أسبوعين أسبوعين
+
+16
+00:00:55,770 --> 00:01:05,930
+أسبوعين أسبوعين أسبوعين أسبوعين أسبوعين
+
+17
+00:01:07,940 --> 00:01:11,200
+القرار اللي لديه في العالم السياسي و في الحياة
+
+18
+00:01:11,200 --> 00:01:16,140
+التجارية هو السحب. أكتر مننا على مباركة يومية نقوم
+
+19
+00:01:16,140 --> 00:01:21,760
+بالبناء القرارات. لأنا و لكم في أكتر الأيام و أكتر
+
+20
+00:01:21,760 --> 00:01:24,360
+الأيام نقوم ببناء القرارات، نشتري أشياء صغيرة
+
+21
+00:01:25,200 --> 00:01:28,060
+buying expensive things it doesn't have to be
+
+22
+00:01:28,060 --> 00:01:31,740
+everyday but most likely if you look back for the
+
+23
+00:01:31,740 --> 00:01:34,660
+past one week for the past two weeks how many
+
+24
+00:01:34,660 --> 00:01:37,460
+times have you made sale contracts any of you any
+
+25
+00:01:37,460 --> 00:01:41,820
+one of you sale contracts this this week last week
+
+26
+00:01:41,820 --> 00:01:46,400
+how many times money you cannot count them
+
+27
+00:01:46,400 --> 00:01:50,220
+sometimes on a daily basis you make some contracts
+
+28
+00:01:50,220 --> 00:01:52,800
+buying sandwich buying
+
+29
+00:01:56,610 --> 00:02:00,790
+stuffs، scarves، glasses، mobile phones، food،
+
+30
+00:02:00,790 --> 00:02:03,010
+paying for the taxi even sometimes، you buy the
+
+31
+00:02:03,010 --> 00:02:07,090
+service، you buy the service، it's not .. it's not
+
+32
+00:02:07,090 --> 00:02:10,550
+always about buying goods، goods هي items،
+
+33
+00:02:10,550 --> 00:02:12,690
+something physical، I can buy computer، I can buy
+
+34
+00:02:12,690 --> 00:02:16,810
+mic، I can buy jacket، sometimes you can buy the
+
+35
+00:02:16,810 --> 00:02:22,090
+service، once you can buy، you pay for somebody to
+
+36
+00:02:22,090 --> 00:02:24,770
+clean the house،It will be for someone to teach,
+
+37
+00:02:25,490 --> 00:02:28,470
+it will be for somebody as a security guard, it
+
+38
+00:02:28,470 --> 00:02:31,350
+will be for someone who fix your computer So you
+
+39
+00:02:31,350 --> 00:02:35,410
+can buy goods and you can buy services, you can
+
+40
+00:02:35,410 --> 00:02:37,930
+buy information if you like, you can, can you?
+
+41
+00:02:38,430 --> 00:02:43,030
+Online sometimes companies buy information, they
+
+42
+00:02:43,030 --> 00:02:48,160
+doولكن هؤلاء الشركات تدفع المال لهذه المعلومات وفي
+
+43
+00:02:48,160 --> 00:02:50,860
+اليوم لو تستطيع ترى هذا في الكثير من المكان وكثير
+
+44
+00:02:50,860 --> 00:02:54,020
+من البلدان تجد أن المساعدات متساوية أكتر من
+
+45
+00:02:54,020 --> 00:02:58,520
+الخيارات. أكتر من الشركات التي تسحب المساعدات تجعل
+
+46
+00:02:58,520 --> 00:03:00,720
+المال أكتر من السحاب اللي يسحب الخيارات والأشياء.
+
+47
+00:03:02,000 --> 00:03:06,960
+وإذا تشوف على سبيل المثال في مدينة كبيرة مثل
+
+48
+00:03:06,960 --> 00:03:12,270
+نيويورك، لندن، توكيوباريس في تلك المدينة الكبيرة
+
+49
+00:03:12,270 --> 00:03:17,150
+لديها شركات و تلك الشركات ماذا تبيع؟ تبيع
+
+50
+00:03:17,150 --> 00:03:21,810
+المعلومات و تبيع المساعدة تبيع الرصاص فقط، يمكنك
+
+51
+00:03:21,810 --> 00:03:25,130
+أن تشتري الرصاص، يمكنك أن تشتري المساعدة، يمكنك أن
+
+52
+00:03:25,130 --> 00:03:34,370
+تشتري المشاركة، شخص كمشاركة يمكنه أن يبيعك الرصاص
+
+53
+00:03:35,750 --> 00:03:39,730
+هو يقدر يعطيك المعلومات والاعتبار لشخص جيد من
+
+54
+00:03:39,730 --> 00:03:47,890
+التعليم ومعرفة ومعرفة ومعرفة ومعرفة ومعرفة ومعرفة
+
+55
+00:03:47,890 --> 00:03:57,650
+ومعرفة
+
+56
+00:04:06,340 --> 00:04:09,140
+لوك in the market when you walk in the main street
+
+57
+00:04:09,140 --> 00:04:12,500
+in the high street عمرو المختار the high street
+
+58
+00:04:12,500 --> 00:04:19,320
+what do you see anyone yes
+
+59
+00:04:19,320 --> 00:04:28,180
+food
+
+60
+00:04:28,180 --> 00:04:35,580
+those are sectors food sector clothesماذا أخرى؟
+
+61
+00:04:35,580 --> 00:04:43,480
+إضافات، إلكترونيكا، مواطنين، أكتر من الممكن أن
+
+62
+00:04:43,480 --> 00:04:47,820
+تجدهم في السوق لذلك يمكنك أن تذهب للتشوية، يمكنك
+
+63
+00:04:47,820 --> 00:04:50,960
+أن تجد مقاطع المال، يمكنك أن تشتري أي شيء تحبه،
+
+64
+00:04:50,960 --> 00:04:55,300
+لكن كيف يمكننا أن نتعامل؟ كيف يمكننا أن نتعامل
+
+65
+00:04:55,300 --> 00:05:02,200
+عملياتنا؟ كيف يمكنني أن أتأكد؟هل مجرد شرح شرح
+
+66
+00:05:02,200 --> 00:05:06,700
+المساعدة صحيح أو ليس صحيح؟ كيف أتأكد من ذلك؟ كما
+
+67
+00:05:06,700 --> 00:05:10,580
+تعلمين بقلبك في بعض الأحيان عندما تعمل شرح
+
+68
+00:05:10,580 --> 00:05:16,010
+المساعدة هذا حسنًاit was legal it was okay because
+
+69
+00:05:16,010 --> 00:05:18,990
+we have the conditions all conditions same thing
+
+70
+00:05:18,990 --> 00:05:21,730
+what we had before last week conditions we have we
+
+71
+00:05:21,730 --> 00:05:25,550
+can apply them but here specifically for sale of
+
+72
+00:05:25,550 --> 00:05:27,630
+goods we have the offer and acceptance
+
+73
+00:05:27,630 --> 00:05:32,650
+consideration and we have the intention and then
+
+74
+00:05:32,650 --> 00:05:36,370
+we have the item itself the goods which we paid
+
+75
+00:05:36,370 --> 00:05:40,850
+the money for because i would like to containلتحصل
+
+76
+00:05:40,850 --> 00:05:43,990
+على الأشياء لذلك يجب أن أدفع المال يجب أن أدفع شيء
+
+77
+00:05:43,990 --> 00:05:48,990
+في محافظة للأشياء لكي تستطيع أن تشتريه لكي تستطيع
+
+78
+00:05:48,990 --> 00:05:55,790
+أن تدفعه لكي تستطيع أن تدفعه لكي تدفعه لكي تدفعه
+
+79
+00:05:55,790 --> 00:06:00,330
+لكي تدفعه لكي تدفعه لكي تدفعه لكي تدفعه لكي تدفعه
+
+80
+00:06:00,330 --> 00:06:00,330
+لكي تدفعه لكي تدفعه لكي تدفعه لكي تدفعه لكي تدفعه
+
+81
+00:06:00,330 --> 00:06:01,050
+لكي تدفعه لكي تدفعه لكي تدفعه لكي تدفعه لكي تدفعه
+
+82
+00:06:01,050 --> 00:06:08,070
+لكي
+
+83
+00:06:08,070 --> 00:06:12,560
+تدفماذا ندرس هو قانون مجتمع مجتمع افعال ندرس سائل
+
+84
+00:06:12,560 --> 00:06:15,560
+الأوضاع هذا يمكن أن يكون مجتمع مجتمع ويمكن أن يكون
+
+85
+00:06:15,560 --> 00:06:17,600
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+86
+00:06:17,600 --> 00:06:19,960
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+87
+00:06:19,960 --> 00:06:21,700
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+88
+00:06:21,700 --> 00:06:23,740
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+89
+00:06:23,740 --> 00:06:23,800
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+90
+00:06:23,800 --> 00:06:31,460
+مجتمع مجتمع مج
+
+91
+00:06:32,970 --> 00:06:35,770
+في أكتر البلدين هذا يمكن أن يكون مجلسًا تسميه
+
+92
+00:06:35,770 --> 00:06:40,590
+قانون شركي أو قانون شركي ولكن بعض الأحيان لدينا
+
+93
+00:06:40,590 --> 00:06:43,810
+حتى قانون خاص خاصة قانون خاصة قانون خاصة قانون
+
+94
+00:06:43,810 --> 00:06:45,150
+خاصة قانون خاصة قانون خاصة قانون خاصة قانون خاصة
+
+95
+00:06:45,150 --> 00:06:45,630
+قانون خاصة قانون خاصة قانون خاصة قانون خاصة قانون
+
+96
+00:06:45,630 --> 00:06:46,550
+خاصة قانون خاصة قانون خاصة قانون خاصة قانون خاصة
+
+97
+00:06:46,550 --> 00:06:46,550
+قانون خاصة قانون خاصة قانون خاصة قانون خاصة قانون
+
+98
+00:06:46,550 --> 00:06:49,270
+خاصة قانون خاصة قانون خاصة قانون خاصة قانون خاصة
+
+99
+00:06:49,270 --> 00:07:00,470
+قانون خاصة قانون خاصة
+
+100
+00:07:00,470 --> 00:07:03,080
+قانونثم ليس فقط في الولايات السعودية، في الكثير من
+
+101
+00:07:03,080 --> 00:07:11,160
+البلدين الأخرى، لديك خاصية قانون فرع، provision،
+
+102
+00:07:11,160 --> 00:07:13,720
+division within the law in general، هذا سيسيطر
+
+103
+00:07:13,720 --> 00:07:16,940
+عامًا على ما يسمى محافظة الأسعار التي تسيطر على ما
+
+104
+00:07:16,940 --> 00:07:20,180
+يسمى قانون
+
+105
+00:07:20,180 --> 00:07:21,420
+فرع
+
+106
+00:07:23,190 --> 00:07:27,490
+goods sold and bought selling and buying only
+
+107
+00:07:27,490 --> 00:07:30,470
+goods we're not talking about service or
+
+108
+00:07:30,470 --> 00:07:35,570
+information no we are talking about goods items we
+
+109
+00:07:35,570 --> 00:07:38,990
+can sell we can buy so this act what does it mean
+
+110
+00:07:38,990 --> 00:07:43,910
+act act
+
+111
+00:07:43,910 --> 00:07:49,070
+no it's not لا we can say code اللي هو تشريع تشريع
+
+112
+00:07:50,420 --> 00:07:55,200
+نستطيع أن نقول كود نستطيع أن نقول اكت وانها كلاهما
+
+113
+00:07:55,200 --> 00:08:00,080
+قوة او اكت قوة او اكت قوة او اكت قوة او اكت قوة او
+
+114
+00:08:00,080 --> 00:08:06,960
+اكت قوة او اكت قوة او اكت
+
+115
+00:08:06,960 --> 00:08:07,440
+قوة اكت قوة اكت قوة اكت قوة اكت قوة اكت قوة اكت
+
+116
+00:08:07,440 --> 00:08:07,440
+قوة اكت قوة اكت قوة اكت قوة اكت قوة اكت قوة اكت
+
+117
+00:08:07,440 --> 00:08:07,440
+قوة اكت قوة اكت قوة اكت قوة اكت قوة اكت قوة اكت
+
+118
+00:08:07,440 --> 00:08:11,940
+قوة اكت قوة
+
+119
+00:08:11,940 --> 00:08:16,820
+اكت قوة اكت
+
+120
+00:08:16,820 --> 00:08:24,070
+قوة اكت قوة اكت قوة اسيكون هناك نقطة أو رقمات
+
+121
+00:08:24,070 --> 00:08:28,950
+تخبرنا عن ماذا نفعل وماذا لا نفعل، كيف نفعل
+
+122
+00:08:28,950 --> 00:08:33,690
+التجارب، كيف نجعلها نجعلها نجعلها نجعلها نجعلها
+
+123
+00:08:33,690 --> 00:08:33,750
+نجعلها نجعلها نجعلها نجعلها نجعلها نجعلها نجعلها
+
+124
+00:08:33,750 --> 00:08:34,030
+نجعلها نجعلها نجعلها نجعلها نجعلها نجعلها نجعلها
+
+125
+00:08:34,030 --> 00:08:34,070
+نجعلها نجعلها نجعلها نجعلها نجعلها نجعلها نجعلها
+
+126
+00:08:34,070 --> 00:08:34,070
+نجعلها نجعلها نجعلها نجعلها نجعلها نجعلها نجعلها
+
+127
+00:08:34,070 --> 00:08:35,190
+نجعلها نجعلها نجعلها نجعلها نجعلها نجعلها نجعلها
+
+128
+00:08:35,190 --> 00:08:41,670
+نجعلها نجعلها نجعلها نجعلها نجعلYou can eat, you
+
+129
+00:08:41,670 --> 00:08:44,910
+can drink, you can go out, you can study, you can
+
+130
+00:08:44,910 --> 00:08:48,490
+buy, you can hire things، you can do many things،
+
+131
+00:08:48,490 --> 00:08:51,430
+not everything، but we believe that usually we
+
+132
+00:08:51,430 --> 00:08:54,810
+have the freedom to act The same thing commercial
+
+133
+00:08:54,810 --> 00:08:59,290
+law and the same is applicable to goods، sale of
+
+134
+00:08:59,290 --> 00:09:05,280
+goodsهذا هو الخيار لكل واحد منكم، أنت لديك الخيار،
+
+135
+00:09:05,280 --> 00:09:08,540
+يمكنك أن تقوم بتجارب، يمكنك أن تشتري أي شيء، يمكنك
+
+136
+00:09:08,540 --> 00:09:11,440
+أن تذهب إلى السوق الآن، إذا كان لديك المال، يمكنك
+
+137
+00:09:11,440 --> 00:09:15,380
+أن تشتري أي شيء، يمكنك أن تشتريه، بما فيه أن هذا
+
+138
+00:09:15,380 --> 00:09:19,620
+التجارب لا يؤثر على أهتمام الشعب بطريقة ناجحة،
+
+139
+00:09:19,620 --> 00:09:21,640
+أعني ليس غير غير غير غير غير غير غير غير غير غير
+
+140
+00:09:21,640 --> 00:09:22,000
+غير غير غير غير غير غير غير غير غير غير غير غير
+
+141
+00:09:22,000 --> 00:09:23,220
+غير غير غير غير غير غير غير غير غير غير غير غير
+
+142
+00:09:23,220 --> 00:09:23,260
+غير غير غير غير غير غير غير غير غير غير غير غير
+
+143
+00:09:23,260 --> 00:09:25,960
+غير غير غكما كانت السابقة السابقة السابقة لدينا
+
+144
+00:09:25,960 --> 00:09:30,020
+بعض النقطة التي يمكن أن تؤثر على وجود المقاومة
+
+145
+00:09:30,020 --> 00:09:33,820
+بشكل نقلي بما يمكننا أن نجلس خارج المقاومة مثل الـ
+
+146
+00:09:33,820 --> 00:09:41,460
+Void و Voidable و Wake up و Unenforceable هل أنت
+
+147
+00:09:41,460 --> 00:09:48,240
+لا تتبعني؟ بسهولة، لماذا يجب أن يكون هناك افتحة
+
+148
+00:09:48,240 --> 00:09:54,620
+الأسواق؟لماذا لا نتركها للإنسان؟ يمكنك أن تكون في
+
+149
+00:09:54,620 --> 00:09:59,620
+حرية، يمكنك أن تدفع، يمكنك أن تفعل ما ترغب به، فلو
+
+150
+00:09:59,620 --> 00:10:06,120
+يمكننا أن نحصل على اتفاق هنا وهذا
+
+151
+00:10:06,120 --> 00:10:06,540
+هو القانون
+
+152
+00:10:11,010 --> 00:10:14,210
+لماذا لا نكون فقط لدينا التطبيق؟ لأننا رأينا آخر
+
+153
+00:10:14,210 --> 00:10:17,590
+مرة أعتقد أن التطبيق هو مصدر مصدر رقم واحد
+
+154
+00:10:17,590 --> 00:10:22,150
+والقانون مصدر رقم اثنان، لذا إذا كان لدينا مصادر،
+
+155
+00:10:22,150 --> 00:10:28,110
+إذا كان لدينا مصادر بين القانون والتطبيق،
+
+156
+00:10:28,110 --> 00:10:33,210
+بين الحكومة والتطبيق، فنستطيع تطبيق التطبيق، وإذا
+
+157
+00:10:33,210 --> 00:10:40,600
+لم نستطيع أن نجد تطبيق تطبيقلتحكم في عملياتنا ثم
+
+158
+00:10:40,600 --> 00:10:43,740
+يجب أن نذهب إلى الـ Act ، إلى القواعد لننظر إليها
+
+159
+00:10:43,740 --> 00:10:50,080
+، لذلك دائما يأتي القواعد أولا ثم في المرحلة
+
+160
+00:10:50,080 --> 00:10:52,860
+الثانوية، في المرحلة الثانوية يجب أن ننظر إلى
+
+161
+00:10:52,860 --> 00:10:55,880
+قواعد
+
+162
+00:10:55,880 --> 00:10:59,780
+سيلة الله لأن
+
+163
+00:10:59,780 --> 00:11:03,340
+هناك شيء يجب أن نحتفظ به في عقلنا، في عقلنا، انظر
+
+164
+00:11:03,340 --> 00:11:08,180
+إليي شيء يجب أن ننظر إليه بحذر، هل لدينا اهتمام أو
+
+165
+00:11:08,180 --> 00:11:12,120
+لا؟هل نحن؟ نعم، إذا كان لدينا هدف، يمكننا أن
+
+166
+00:11:12,120 --> 00:11:14,380
+نختاره إذا كان لدينا هدف، يمكننا أن نختاره إذا كان
+
+167
+00:11:14,380 --> 00:11:16,700
+لدينا هدف، يمكننا أن نختاره إذا كان لدينا هدف،
+
+168
+00:11:16,700 --> 00:11:16,820
+يمكننا أن نختاره إذا كان لدينا هدف، يمكننا أن
+
+169
+00:11:16,820 --> 00:11:17,140
+نختاره إذا كان لدينا هدف، يمكننا أن نختاره إذا كان
+
+170
+00:11:17,140 --> 00:11:17,600
+لدينا هدف، يمكننا أن نختاره إذا كان لدينا هدف،
+
+171
+00:11:17,600 --> 00:11:18,420
+يمكننا أن نختاره إذا كان لدينا هدف، يمكننا أن
+
+172
+00:11:18,420 --> 00:11:19,400
+نختاره إذا كان لدينا هدف، يمكننا أن نختاره إذا كان
+
+173
+00:11:19,400 --> 00:11:23,700
+لدينا هدف، يمكننا أن نختاره إذا كان لدينا هدف،
+
+174
+00:11:23,700 --> 00:11:28,340
+يمكننا أن
+
+175
+00:11:28,340 --> 00:11:36,970
+نختارإذا انا اشتغل مع شخص اخر اشتغل
+
+176
+00:11:36,970 --> 00:11:40,970
+معه اشتغل معه اشتغل معه اشتغل معه اشتغل معه اشتغل
+
+177
+00:11:40,970 --> 00:11:40,970
+معه اشتغل معه اشتغل معه اشتغل معه اشتغل معه اشتغل
+
+178
+00:11:40,970 --> 00:11:41,110
+معه اشتغل معه اشتغل معه اشتغل معه اشتغل معه اشتغل
+
+179
+00:11:41,110 --> 00:11:41,370
+معه اشتغل معه اشتغل معه اشتغل معه اشتغل معه اشتغل
+
+180
+00:11:41,370 --> 00:11:41,430
+معه اشتغل معه اشتغل معه اشتغل معه اشتغل معه اشتغل
+
+181
+00:11:41,430 --> 00:11:54,490
+معه اشتغل معه اشتغل معه اشتغل معه اشتغل
+
+182
+00:11:54,490 --> 00:12:01,690
+معuncertain terms or sometimes you have implicit
+
+183
+00:12:01,690 --> 00:12:09,590
+terms then if we have any fault or any any clause
+
+184
+00:12:09,590 --> 00:12:12,830
+here or any term which has to be explained we
+
+185
+00:12:12,830 --> 00:12:16,330
+cannot explain it or any term was uncertain or
+
+186
+00:12:16,330 --> 00:12:18,870
+something we did not sit from the beginning we did
+
+187
+00:12:18,870 --> 00:12:22,550
+not agree upon then if this contract is not full
+
+188
+00:12:23,580 --> 00:12:26,700
+إذا لم يكن مميزاً تماماً أو مميزاً تماماً أو
+
+189
+00:12:26,700 --> 00:12:27,400
+مميزاً تماماً أو مميزاً تماماً أو مميزاة تماماً أو
+
+190
+00:12:27,400 --> 00:12:28,140
+مميزاة تماماً أو مميزاة تماماً أو مميزاة تماماً أو
+
+191
+00:12:28,140 --> 00:12:28,500
+مميزاة تماماً أو مميزاة تماماً أو مميزاة تماماً أو
+
+192
+00:12:28,500 --> 00:12:29,780
+مميزاة تماماً أو مميزاة تماماً أو مميزاة تماماً أو
+
+193
+00:12:29,780 --> 00:12:32,320
+مميزاة تماماً أو مميزاة تماماً أو مميزاة تماماً أو
+
+194
+00:12:32,320 --> 00:12:37,000
+مميزاة تماماً أو مميزاة تماماً أو
+
+195
+00:12:37,000 --> 00:12:42,600
+مميزاة تماماً
+
+196
+00:12:52,740 --> 00:12:54,520
+باستخدام حكومة السحب الخاص بنا باستخدام حكومة
+
+197
+00:12:54,520 --> 00:12:55,200
+السحب الخاص بنا باستخدام حكومة السحب الخاص بنا
+
+198
+00:12:55,200 --> 00:12:58,480
+باستخدام حكومة السحب الخاص بنا باستخدام حكومة
+
+199
+00:12:58,480 --> 00:13:03,860
+السحب الخاص بنا باستخدام حكومة السحب الخاص بنا
+
+200
+00:13:03,860 --> 00:13:07,120
+باستخدام
+
+201
+00:13:07,120 --> 00:13:07,920
+حكومة السحب الخاص بنا باستخدام حكومة السحب الخاص
+
+202
+00:13:07,920 --> 00:13:11,200
+بنا باستخدام حكومة السحب الخاص بنا باستخدام حكومة
+
+203
+00:13:11,200 --> 00:13:17,560
+السحب الخاص بنا باستخدام
+
+204
+00:13:17,560 --> 00:13:24,700
+حكومة السحب الخاص بناانا فقط اجاب السؤال الآن
+
+205
+00:13:24,700 --> 00:13:31,020
+بإدعاء العلاقة بين العملي و العملي نحن نحب
+
+206
+00:13:31,020 --> 00:13:40,920
+العمليات و نحب العمليات نحب العمليات نحب
+
+207
+00:13:40,920 --> 00:13:41,000
+العمليات نحب العمليات نحب العمليات نحب العمليات
+
+208
+00:13:41,000 --> 00:13:41,240
+نحب العمليات نحب العمليات نحب العمليات نحب
+
+209
+00:13:41,240 --> 00:13:41,240
+العمليات نحب العمليات نحب العمليات نحب العمليات
+
+210
+00:13:41,240 --> 00:13:41,240
+نحب العمليات نحب العمليات نحب العمليات نحب
+
+211
+00:13:41,240 --> 00:13:41,240
+العمليات نحب العمليات نحب العمليات نحب العمليات
+
+212
+00:13:41,240 --> 00:13:41,320
+نحب العمليات نحب العمليات نحب العمليات نحب
+
+213
+00:13:41,320 --> 00:13:50,520
+العمليات نحب العمليات نحب العمليات نحب
+
+214
+00:13:52,810 --> 00:13:56,550
+يجب أن نكمل الفترة في المعاملات لأن هذا الاختصار
+
+215
+00:13:56,550 --> 00:14:01,930
+سيكمل أهدافنا لأننا لسنا لدينا عقلين مفاليين لسنا
+
+216
+00:14:01,930 --> 00:14:05,350
+لدينا أهداف مفالية وإذا فقدفنا الموضوع فهذا
+
+217
+00:14:05,350 --> 00:14:12,010
+الموضوع يمكن أن يتم إكماله ويتم تفسيره من خلال
+
+218
+00:14:12,010 --> 00:14:17,110
+الاختصار الخاص بنا هذا هو السبب لأن هذا الاختصار
+
+219
+00:14:17,110 --> 00:14:23,590
+يأتي ببعض من الانتصاراتtwo main divisions number
+
+220
+00:14:23,590 --> 00:14:28,650
+one is this act lays out lays out setting
+
+221
+00:14:28,650 --> 00:14:34,630
+explaining establishing small number of compulsory
+
+222
+00:14:34,630 --> 00:14:39,850
+legal rules which are restrictions minimal
+
+223
+00:14:39,850 --> 00:14:46,100
+restriction what's restriction قيود قيودminimal
+
+224
+00:14:46,100 --> 00:14:50,800
+minimum minimal restriction so this act giving us
+
+225
+00:14:50,800 --> 00:14:54,580
+the freedom you can act we only have minimal
+
+226
+00:14:54,580 --> 00:14:58,500
+restriction you have to follow them you are guided
+
+227
+00:14:58,500 --> 00:15:02,720
+you have to abide by these by these points number
+
+228
+00:15:02,720 --> 00:15:07,360
+two the same act 1979 act sale of goods act
+
+229
+00:15:07,360 --> 00:15:12,140
+looking at the bulk the bulkmost of it the
+
+230
+00:15:12,140 --> 00:15:16,280
+majority the whole المجموع most of it bulk of the
+
+231
+00:15:16,280 --> 00:15:22,060
+act is concerned with what with perception
+
+232
+00:15:22,060 --> 00:15:25,760
+presumptions presumptions not presumption here
+
+233
+00:15:25,760 --> 00:15:31,400
+it's perceptions فرضيات that what we have in our
+
+234
+00:15:31,400 --> 00:15:37,320
+minds it's it's like like like what this act will
+
+235
+00:15:37,320 --> 00:15:43,100
+assume what we're thinking ofsomeone someone would
+
+236
+00:15:43,100 --> 00:15:47,420
+assume that I was thinking in this way assuming
+
+237
+00:15:47,420 --> 00:15:52,320
+that why because this law this act is made by
+
+238
+00:15:52,320 --> 00:15:57,040
+specialists by schoolers and those schoolers most
+
+239
+00:15:57,040 --> 00:16:00,960
+likely have the experience by definite have the
+
+240
+00:16:00,960 --> 00:16:03,940
+experience and knowledge and skills and education
+
+241
+00:16:03,940 --> 00:16:07,400
+and they can assume they can presume يعتقد أو
+
+242
+00:16:07,400 --> 00:16:08,660
+يتوقع
+
+243
+00:16:10,410 --> 00:16:16,050
+unemployed terms employed so these ads here to
+
+244
+00:16:16,050 --> 00:16:21,190
+have some points these points are employed in the
+
+245
+00:16:21,190 --> 00:16:25,590
+contract assuming assuming what يعني بنعتقد
+
+246
+00:16:25,590 --> 00:16:29,370
+assuming that these terms here will complete our
+
+247
+00:16:29,370 --> 00:16:34,180
+intentioncomplete our intention لذلك what .. what
+
+248
+00:16:34,180 --> 00:16:36,540
+we have in .. in Arabic law what we say one of the
+
+249
+00:16:36,540 --> 00:16:39,120
+main .. one of the main points اللي بيسموها
+
+250
+00:16:39,120 --> 00:16:45,340
+القواعد المكملة قمل to complete these complete
+
+251
+00:16:45,340 --> 00:16:48,100
+rules would complete .. these rules would complete
+
+252
+00:16:48,100 --> 00:16:52,240
+our intention complete our intention here as if we
+
+253
+00:16:52,240 --> 00:16:54,720
+have missed one page like if you look .. look at
+
+254
+00:16:54,720 --> 00:16:57,200
+your .. look at your book how many pages two
+
+255
+00:16:57,200 --> 00:16:58,780
+hundred yeah
+
+256
+00:17:00,990 --> 00:17:03,890
+تخيل أن هذا هو الكتاب و هذا هو التجارب .. هذا هو
+
+257
+00:17:03,890 --> 00:17:08,170
+التجارب بينك و أنا .. الكتاب 200 مقالات .. الأن
+
+258
+00:17:08,170 --> 00:17:11,550
+إذا وجدت خمس مقالات مفقودة من الكتاب، ماذا يمكنك
+
+259
+00:17:11,550 --> 00:17:18,150
+أن تفعل؟ خمس مقالات مفقودة من هذا الكتاب .. خمس
+
+260
+00:17:18,150 --> 00:17:22,210
+مقالات مفقودة .. بخطأ .. ب .. ب .. ب .. ب .. ب ..
+
+261
+00:17:22,210 --> 00:17:23,610
+ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب ..
+
+262
+00:17:23,610 --> 00:17:24,470
+ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب ..
+
+263
+00:17:24,470 --> 00:17:24,810
+ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب ..
+
+264
+00:17:24,810 --> 00:17:25,170
+ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب ..
+
+265
+00:17:25,170 --> 00:17:26,010
+ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب ..
+
+266
+00:17:26,010 --> 00:17:32,930
+ب .. ب .. ب ..يجب أن نبحث عنها، نفس الشيء، هذا هو
+
+267
+00:17:32,930 --> 00:17:36,250
+التطبيق هنا أحيانًا مفقود، مفقود في بعض الأوراق،
+
+268
+00:17:36,250 --> 00:17:38,650
+بعض النقطة، بعض الاتصالات، ولكن هذه الاتصالات
+
+269
+00:17:38,650 --> 00:17:42,710
+ستجدهم في مكان ما في الواقع، لذا فإن هذا الواقع
+
+270
+00:17:42,710 --> 00:17:48,330
+سيكتمل تغييره، سيوضح التطبيق، سيجعل كل شيء ممكن
+
+271
+00:17:48,330 --> 00:17:55,470
+وسهل لجميع الشركات A وB، هل ليس بخير حتى الآن؟ لذا
+
+272
+00:17:55,470 --> 00:17:59,460
+فإن هذا الواقع سيوضح Dcommercial expectations
+
+273
+00:17:59,460 --> 00:18:02,840
+expectation as I said now our expectation that
+
+274
+00:18:02,840 --> 00:18:06,600
+this book or this contract was full perfect legal
+
+275
+00:18:06,600 --> 00:18:10,720
+then we find something wrong what can we do oh
+
+276
+00:18:10,720 --> 00:18:14,080
+yeah reflect the expectations in the most commonly
+
+277
+00:18:14,080 --> 00:18:18,440
+agreed sale contracts يعني بغطي كل جوانب النقص
+
+278
+00:18:18,440 --> 00:18:24,670
+general will cover all the shortageوالنقطة اللي
+
+279
+00:18:24,670 --> 00:18:27,990
+يمكن أن تكون مفقودة في التجارب. إنها تجارب مفهومة
+
+280
+00:18:27,990 --> 00:18:33,050
+لأن في الواقع .. في القواعد كما قلت قبل أن بعض
+
+281
+00:18:33,050 --> 00:18:37,730
+المدرسين الذين يكونوا مستخدمين يجلسوا لأشهر و أشهر
+
+282
+00:18:37,730 --> 00:18:41,990
+يعملوا الواقع، يعملوا الواقع و يستطيعون أن يقوموا
+
+283
+00:18:41,990 --> 00:18:47,550
+بمعرفةه عدة مرات و هذا سيكون كتابة في الحكومة و
+
+284
+00:18:47,550 --> 00:18:50,010
+تفقده .. كتابه للمرة الأولى و للمرة الثانية و
+
+285
+00:18:50,010 --> 00:18:52,170
+للمرة الثالثة و بعد ذلك يجب أن تقوموا بالتعامل مع
+
+286
+00:18:52,170 --> 00:18:58,110
+ذلكهذا العمل يتطور من خلال طريقة طويلة إلى أن
+
+287
+00:18:58,110 --> 00:19:03,230
+ننتهي منها بعد طريقة طويلة من هذا البرنامج هذا من
+
+288
+00:19:03,230 --> 00:19:06,270
+المفترض أن يكون قريب من الانتصاف ليس انتصافي لا
+
+289
+00:19:06,270 --> 00:19:10,890
+شيء انتصافي في حياتنا كإنسان لا نكون انتصافي لذلك
+
+290
+00:19:10,890 --> 00:19:15,550
+هذا يمكن أن يكون قريب من الانتصاف ولكن التعامل
+
+291
+00:19:15,550 --> 00:19:20,810
+نفسه يتأكد من أننا سوف نحصل على بعض الخطوات بعض
+
+292
+00:19:20,810 --> 00:19:25,650
+الانتصافthen in all cases we have to bring the law
+
+293
+00:19:25,650 --> 00:19:30,450
+and then we apply it in the contract why because
+
+294
+00:19:30,450 --> 00:19:34,870
+we would like to make the situation as perfect as
+
+295
+00:19:34,870 --> 00:19:38,090
+we can we would like to sustain the ability of two
+
+296
+00:19:38,090 --> 00:19:41,510
+parties to keep their commitment to the contract
+
+297
+00:19:41,510 --> 00:19:47,530
+okay look atthis again here this sentence here can
+
+298
+00:19:47,530 --> 00:19:52,050
+you read it anyone of you anyone volunteer in the
+
+299
+00:19:52,050 --> 00:19:55,290
+absence of the contrary agreement this sentence
+
+300
+00:19:55,290 --> 00:20:01,450
+will cover a paragraph within the acts in it okay
+
+301
+00:20:01,450 --> 00:20:07,010
+can you understand it in the absence في غياب in
+
+302
+00:20:07,010 --> 00:20:10,730
+the absence of the contrary agreement here يعني في
+
+303
+00:20:10,730 --> 00:20:14,270
+عقود في بنود مخالفة contrary agreement like number
+
+304
+00:20:14,270 --> 00:20:23,710
+onetwo three four one two three four if we don't
+
+305
+00:20:23,710 --> 00:20:27,890
+find any term in the contract contrary اللي هو
+
+306
+00:20:27,890 --> 00:20:33,630
+which means يعني عكس أو ضد to this act then this
+
+307
+00:20:33,630 --> 00:20:37,070
+act will be applicable if there is nothing in the
+
+308
+00:20:37,070 --> 00:20:40,850
+contract to exclude the law if we don't have any
+
+309
+00:20:40,850 --> 00:20:43,770
+term in this contract excluding the law the act
+
+310
+00:20:43,770 --> 00:20:49,720
+then this act isبالطبع فهذا الواقع سيسيطر على
+
+311
+00:20:49,720 --> 00:20:54,940
+التطبيق داخل تطبيق الواقع إذا لم يكن هناك تطبيق أو
+
+312
+00:20:54,940 --> 00:21:00,060
+تجارب في التطبيق تتخلص من القانون أو تتخلص من جزء
+
+313
+00:21:00,060 --> 00:21:07,300
+من القانون فالقانون سيسيطر على الواقع حسنًا
+
+314
+00:21:07,300 --> 00:21:10,780
+هل حصلت على النقطة؟ لا بقول مثل
+
+315
+00:21:15,610 --> 00:21:21,330
+هذا التقرير هنا a b c d لدينا بعض التعاملات و يجب
+
+316
+00:21:21,330 --> 00:21:26,470
+أن نتعامل مع هذه التعاملات تتبع تعامل التقرير كما
+
+317
+00:21:26,470 --> 00:21:30,410
+قلته ولكن إذا كان هناك خطأ هنا كيف يمكننا أن
+
+318
+00:21:30,410 --> 00:21:33,730
+نحلها؟ يمكننا أن نذهب إلى القواعد ولكن إذا كنا ..
+
+319
+00:21:33,730 --> 00:21:37,210
+إذا كنا نحب أن نخرج من القواعد هل نستطيع او لا؟
+
+320
+00:21:37,210 --> 00:21:41,210
+سأتحدث عن هذا الموضوع بعد عدة صفحات يمكننا أن نخرج
+
+321
+00:21:41,210 --> 00:21:47,010
+من القواعدبإمكاننا تخلص من هذه القوة تماما لنا لأن
+
+322
+00:21:47,010 --> 00:21:52,230
+هذه القوة سوف تكمل عقلنا سوف تكمل أهدافنا وإذا لم
+
+323
+00:21:52,230 --> 00:21:56,230
+نرغب في هذا الاختلاف بإمكاننا تخلصه تماما لنا
+
+324
+00:21:56,230 --> 00:22:02,910
+بإمكاننا أن نبقى في القواعد هنا لا اختلاف من عام
+
+325
+00:22:02,910 --> 00:22:08,370
+1979 لا نريد ذلك بإمكاننا تخلص من هذا الاختلاف من
+
+326
+00:22:08,370 --> 00:22:09,190
+عام 1979
+
+327
+00:22:11,870 --> 00:22:16,610
+إذا لم يكن لدينا أي شيء في المقاومة عكس يعني عكس
+
+328
+00:22:16,610 --> 00:22:22,210
+عكس هذا الاختصار فهذا الاختصار سيكون مستعمل لذا
+
+329
+00:22:22,210 --> 00:22:26,050
+إذا لم نتخلص من الاختصار نحن لو ما استثناش نضبط
+
+330
+00:22:26,050 --> 00:22:34,330
+نعم
+
+331
+00:22:34,330 --> 00:22:39,630
+الوصفة الرقم 2 الوصفة الرقم 1 و الوصفة الرقم 2 من
+
+332
+00:22:39,630 --> 00:22:40,310
+عملياتنا
+
+333
+00:23:05,810 --> 00:23:12,170
+لو احنا من البداية استثنناهالن نستطيع استخدامه،
+
+334
+00:23:12,170 --> 00:23:17,810
+أليس كذلك؟ بسبب
+
+335
+00:23:17,810 --> 00:23:22,090
+أفعال هذه القاعدة، بسبب أفعال هذه القاعدة، العديد
+
+336
+00:23:22,090 --> 00:23:24,850
+من البلدين قامت بإستخدام قاعدة مثلها، ليس فقط في
+
+337
+00:23:24,850 --> 00:23:28,390
+الولايات المتحدة، ليس فقط في بريطانيا، العديد من
+
+338
+00:23:28,390 --> 00:23:32,410
+البلدان الأوروبية قامت بإستخدام قاعدة مثلها،
+
+339
+00:23:32,410 --> 00:23:37,770
+بإستخدامها لإكمال أهداف الشركات، هنا القاعدة تتضمن
+
+340
+00:23:37,770 --> 00:23:39,210
+لجميع القواعدات
+
+341
+00:23:41,530 --> 00:23:43,490
+عن طريق اتخاذ اتخاذ اتخاذ اتخاذ اتخاذ اتخاذ اتخاذ
+
+342
+00:23:43,490 --> 00:23:48,490
+اتخاذ اتخاذ اتخاذ اتخاز اتخاز اتخاز اتخاز اتخاز
+
+343
+00:23:48,490 --> 00:23:48,670
+اتخاز اتخاز اتخاز اتخاز اتخاز اتخاز اتخاز اتخاز
+
+344
+00:23:48,670 --> 00:23:49,950
+اتخاز اتخاز اتخاز اتخاز اتخاز اتخاز اتخاز اتخاز
+
+345
+00:23:49,950 --> 00:23:52,790
+اتخاز اتخاز اتخاز اتخاز اتخاز اتخاز اتخاز اتخاز
+
+346
+00:23:52,790 --> 00:23:52,830
+اتخاز اتخاز اتخاز اتخاز اتخاز اتخاز اتخاز اتخاز
+
+347
+00:23:52,830 --> 00:24:00,890
+اتخاز اتخاز اتخاز اتخاز اتخاز اتخاز اتخاز اتخ
+
+348
+00:24:00,990 --> 00:24:06,330
+we can apply it if we have goods transferred for
+
+349
+00:24:06,330 --> 00:24:09,870
+the money or similar situation here transferred
+
+350
+00:24:09,870 --> 00:24:14,830
+for the money for the monetary consideration so
+
+351
+00:24:14,830 --> 00:24:18,210
+only we can apply this act if we have sale of
+
+352
+00:24:18,210 --> 00:24:24,170
+goods goods or items for money simple is that
+
+353
+00:24:24,170 --> 00:24:31,710
+difficult isn't it is it fine now goodفي هذه
+
+354
+00:24:31,710 --> 00:24:36,590
+الصفحة الآن ما يجب أن نرى هو مصطلحات مصطلحات ترمز
+
+355
+00:24:36,590 --> 00:24:43,210
+ترمز مصطلحات مصطلحات مصطلحات مصطلحات مصطلحات
+
+356
+00:24:43,210 --> 00:24:44,490
+مصطلحات مصطلحات مصطلحات مصطلحات مصطلحات مصطلحات
+
+357
+00:24:44,490 --> 00:24:44,550
+مصطلحات مصطلحات مصطلحات مصطلحات مصطلحات مصطلحات
+
+358
+00:24:44,550 --> 00:24:44,590
+مصطلحات مصطلحات مصطلحات مصطلحات مصطلحات مصطلحات
+
+359
+00:24:44,590 --> 00:24:44,710
+مصطلحات مصطلحات مصطلحات مصطلحات مصطلحات مصطلحات
+
+360
+00:24:44,710 --> 00:24:45,570
+مصطلحات مصطلحات م
+
+361
+00:24:58,790 --> 00:25:03,150
+كما يمكننا أن نرىهم ونكتب عنهم ونتحدث عنهم وفي نفس
+
+362
+00:25:03,150 --> 00:25:05,870
+الوقت لدينا بعض التعاملات الانبليزية وهذه
+
+363
+00:25:05,870 --> 00:25:10,090
+التعاملات الانبليزية مفهومة في القانون في الواقع
+
+364
+00:25:10,090 --> 00:25:14,890
+مفهومة هنا ترى هم؟ واضحين واضحين وفي نفس الوقت هذه
+
+365
+00:25:14,890 --> 00:25:20,530
+التعاملات الانبليزية في الواقع مفهومة في التعاملات
+
+366
+00:25:20,530 --> 00:25:24,810
+الانبليزية في التعاملات إذا قررنا واحد من هذه
+
+367
+00:25:24,810 --> 00:25:27,910
+التعاملات واحد من هذه التعاملاتثم يكون لدينا بعض
+
+368
+00:25:27,910 --> 00:25:31,710
+التأثيرات لكن هذا ليس شيء جديد لك لأننا قبل مره
+
+369
+00:25:31,710 --> 00:25:34,130
+قبل مره قبل مره قبل مره قبل مره قبل مره قبل مره
+
+370
+00:25:34,130 --> 00:25:35,170
+قبل مره قبل مره قبل مره قبل مره قبل مره قبل مره
+
+371
+00:25:35,170 --> 00:25:35,630
+قبل مره قبل مره قبل مره قبل مره قبل مره قبل مره
+
+372
+00:25:35,630 --> 00:25:35,730
+قبل مره قبل مره قبل مره قبل مره قبل مره قبل مره
+
+373
+00:25:35,730 --> 00:25:35,730
+قبل مره قبل مره قبل مره قبل مره قبل مره قبل مره
+
+374
+00:25:35,730 --> 00:25:38,710
+قبل مره قبل مره قبل مره قبل مره قبل مره قبل مره
+
+375
+00:25:38,710 --> 00:25:43,310
+قبل مره قبل
+
+376
+00:25:43,310 --> 00:25:49,930
+مره ق
+
+377
+00:25:50,780 --> 00:25:53,480
+and even if it's it doesn't matter if it's
+
+378
+00:25:53,480 --> 00:25:55,440
+explicit or implicit it doesn't make any
+
+379
+00:25:55,440 --> 00:25:59,200
+difference condition is a condition whether it's
+
+380
+00:25:59,200 --> 00:26:03,600
+explicit or implicit سواء ضمنى او صريحى and
+
+381
+00:26:03,600 --> 00:26:06,340
+warranty is a warranty so what's the difference
+
+382
+00:26:06,340 --> 00:26:08,920
+you might have a question like this what's the
+
+383
+00:26:08,920 --> 00:26:11,000
+difference between the condition and warranty this
+
+384
+00:26:11,000 --> 00:26:16,940
+is a question gone condition and warrant easy this
+
+385
+00:26:16,940 --> 00:26:18,000
+is an easy question
+
+386
+00:26:23,180 --> 00:26:24,960
+before that what's the condition?
+
+387
+00:26:27,780 --> 00:26:34,680
+okay yes which kind of terms condition
+
+388
+00:26:34,680 --> 00:26:39,800
+it's something essential yes something important
+
+389
+00:26:39,800 --> 00:26:44,300
+the contract cannot stand without it so if we have
+
+390
+00:26:44,300 --> 00:26:48,620
+a breach then this breach can lead to termination
+
+391
+00:26:48,620 --> 00:26:56,010
+of the contractthen preach يخالف failing you can
+
+392
+00:26:56,010 --> 00:26:59,930
+define it in the exam preach is failing failing to
+
+393
+00:26:59,930 --> 00:27:03,670
+perform as stated in the contract cannot fulfill
+
+394
+00:27:03,670 --> 00:27:09,710
+his duties his commitment preach يخالف now okay
+
+395
+00:27:09,710 --> 00:27:15,370
+warranty what does it meanلأ ليس كذلك لا أستطيع أن
+
+396
+00:27:15,370 --> 00:27:18,290
+أترجمها من الإنقليزة إلى العربية بطريقة عامة لديها
+
+397
+00:27:18,290 --> 00:27:23,430
+اثنين معنى، الوضع هو شيء أهم ومهم في المجلد ولكن
+
+398
+00:27:23,430 --> 00:27:27,730
+الوارنتيز .. هل هناك فرصة في المجلد؟ لا هيا قبل
+
+399
+00:27:27,730 --> 00:27:33,170
+ذلك هل هذا شيء مهم؟ لا هذا ليس مهم، هذا ليس مهم،
+
+400
+00:27:33,170 --> 00:27:38,610
+هذا ليس مهم إذا كان هناك فرصة في المجلد فهناك
+
+401
+00:27:38,610 --> 00:27:40,190
+مستخدمين
+
+402
+00:27:47,970 --> 00:27:51,910
+Okay, so this case can be applicable to the same
+
+403
+00:27:51,910 --> 00:27:58,550
+thing to implicit terms because we have now the
+
+404
+00:27:58,550 --> 00:28:02,850
+1979 act, sale of goods act, the whole act as you
+
+405
+00:28:02,850 --> 00:28:06,510
+can see it, the whole act is implicit in the
+
+406
+00:28:06,510 --> 00:28:10,070
+contract, so all these termsلدينا الكثير من كلمات
+
+407
+00:28:10,070 --> 00:28:16,210
+وكثير من صفحات في الحكومة كلها مضمونة في التطبيق
+
+408
+00:28:16,210 --> 00:28:25,450
+نستطيع أن نقلها إلى تطبيقات وموارنتي تعتمد على كل
+
+409
+00:28:25,450 --> 00:28:29,470
+حالة أحيانا تكون تطبيق يمكن أن يكون مصطلح في
+
+410
+00:28:29,470 --> 00:28:36,860
+التطبيق نفسه لأن حكومة 1979 قررت أن تضمنبعض
+
+411
+00:28:36,860 --> 00:28:42,040
+الاصطلاعات تقول ان هذه اصطلاعات اخرى اخرى تسمى
+
+412
+00:28:42,040 --> 00:28:45,520
+اصطلاعات تسمى ورانتيز اذا تنظر إلى نفس التجارب
+
+413
+00:28:45,520 --> 00:28:49,300
+تستطيع ان تعرف اصطلاع و ورانتيز اذا تنظر إلى
+
+414
+00:28:49,300 --> 00:28:51,940
+اصطلاع نفسها تستطيع ان ترى الفرق بين اصطلاع و
+
+415
+00:28:51,940 --> 00:28:56,010
+ورانتيز على الرغم من هذا نحن لدينا بعض الحالاتsome
+
+416
+00:28:56,010 --> 00:28:58,910
+terms we cannot make sure if these are conditions
+
+417
+00:28:58,910 --> 00:29:01,790
+of warranty we have to look at the objective
+
+418
+00:29:01,790 --> 00:29:06,110
+perspective objectivity the judge a reasonable
+
+419
+00:29:06,110 --> 00:29:11,090
+person we look at the importance of each term do
+
+420
+00:29:11,090 --> 00:29:15,050
+you understand what I'm saying I hope so are you
+
+421
+00:29:15,050 --> 00:29:18,950
+sure you can have an equation like this in the
+
+422
+00:29:18,950 --> 00:29:24,020
+exam by the way you willSo condition someone can
+
+423
+00:29:24,020 --> 00:29:27,420
+you can you read it here؟ انا حنين if the terms
+
+424
+00:29:27,420 --> 00:29:30,980
+are conditional and if they perish or burn means
+
+425
+00:29:30,980 --> 00:29:34,300
+determination or submission okay we have one of
+
+426
+00:29:34,300 --> 00:29:37,840
+the terms number two number two in the act it's
+
+427
+00:29:37,840 --> 00:29:42,940
+talking about quality quality
+
+428
+00:29:42,940 --> 00:29:46,240
+so if we have a breach in this condition
+
+429
+00:29:48,930 --> 00:29:55,090
+ثم كل مجلد يرى أن هذا و هذا يكون جزء من مجلد واحد
+
+430
+00:29:55,090 --> 00:29:58,890
+مجلد واحد مجلد واحد مجلد واحد مجلد واحد مجلد واحد
+
+431
+00:29:58,890 --> 00:29:59,130
+مجلد واحد مجلد واحد مجلد واحد مجلد واحد مجلد واحد
+
+432
+00:29:59,130 --> 00:29:59,810
+مجلد واحد مجلد واحد مجلد واحد مجلد واحد مجلد واحد
+
+433
+00:29:59,810 --> 00:30:00,750
+مجلد واحد مجلد واحد مجلد واحد مجلد واحد مجلد واحد
+
+434
+00:30:00,750 --> 00:30:02,230
+مجلد واحد مجلد واحد مجلد واحد مجلد واحد مجلد واحد
+
+435
+00:30:02,230 --> 00:30:02,230
+مجلد واحد مجلد واحد مجلد واحد مجلد واحد مجلد واحد
+
+436
+00:30:02,230 --> 00:30:16,250
+مجلد واحد مجلد واحد مجلد واحد
+
+437
+00:30:17,220 --> 00:30:20,420
+أو انها اختيارك .. اعني اذا كانت الشخصية لديها
+
+438
+00:30:20,420 --> 00:30:24,660
+اختيار يمكنك ان تكون لديك المال او يمكنك ان تطلع
+
+439
+00:30:24,660 --> 00:30:28,600
+على انتهاء هذا التجارب إذا كانت هذه التجارب .. إذا
+
+440
+00:30:28,600 --> 00:30:29,960
+كانت هذه التجارب .. إذا كانت هذه التجارب .. إذا
+
+441
+00:30:29,960 --> 00:30:30,540
+كانت هذه التجارب .. إذا كانت هذه التجارب .. إذا
+
+442
+00:30:30,540 --> 00:30:30,540
+كانت هذه التجارب .. إذا كانت هذه التجارب .. إذا
+
+443
+00:30:30,540 --> 00:30:30,900
+كانت هذه التجارب .. إذا كانت هذه التجارب .. إذا
+
+444
+00:30:30,900 --> 00:30:32,340
+كانت هذه التجارب .. إذا كانت هذه التجارب .. إذا
+
+445
+00:30:32,340 --> 00:30:34,340
+كانت هذه التجارب .. إذا كانت هذه التجارب .. إذا
+
+446
+00:30:34,340 --> 00:30:38,980
+كانت هذه التجارب .. إذا كانت هذه التجارب .. إذا
+
+447
+00:30:38,980 --> 00:30:43,280
+كانت هذه التجارب .. إذا كانت هذه التانها ليست كذلك
+
+448
+00:30:43,280 --> 00:30:46,840
+لأن ورنتيه ليست شيء مهم يمكن أن يكون في بعض
+
+449
+00:30:46,840 --> 00:30:53,220
+الأحيان شيء ثانوي ثانويا شيء ثانوي للشركة مثل
+
+450
+00:30:53,220 --> 00:30:58,420
+الموقع و هذا لن يؤثر على الشركة في بعض الأحيان
+
+451
+00:30:58,420 --> 00:31:01,580
+يمكن أن يكون مثل هذا هنا في هذه الحالة ليست مفهومة
+
+452
+00:31:01,580 --> 00:31:08,660
+انها غير مفهومةللبائر أن ينفذ الأموال لـ breach of
+
+453
+00:31:08,660 --> 00:31:11,380
+implied terms as to description, equality,
+
+454
+00:31:11,540 --> 00:31:17,040
+fitness, sample, if these are warranties. But if
+
+455
+00:31:17,040 --> 00:31:19,820
+they were conditions, then I can reject the whole
+
+456
+00:31:19,820 --> 00:31:25,200
+contract. As a buyer, if I buy something, goods,
+
+457
+00:31:25,380 --> 00:31:30,010
+items,أنا أستطيع الحصول على الاختيار إذا كانت
+
+458
+00:31:30,010 --> 00:31:33,730
+الشركة الثانوية ممكنة تحطم المصطلح إنها اختصاري
+
+459
+00:31:33,730 --> 00:31:36,650
+أستطيع تنقل كل المعقدة أو أستطيع أن أطلب المال
+
+460
+00:31:36,650 --> 00:31:42,910
+منها إذا كانت تحت ورونتي كشركة مبيعية لن أستطيع
+
+461
+00:31:42,910 --> 00:31:45,690
+تنقل المعقدة لا أستطيع أن أقول إنني لا أريد
+
+462
+00:31:45,690 --> 00:31:51,210
+المعقدة بعد الأن سأتخلص منها سأتخلص منها لأنها لم
+
+463
+00:31:51,210 --> 00:31:57,050
+تتم تحطمها في المكان اللذي نريدهit was not up to
+
+464
+00:31:57,050 --> 00:31:59,410
+the specification we wanted it was something
+
+465
+00:31:59,410 --> 00:32:03,490
+similar something can do the same job if it's a
+
+466
+00:32:03,490 --> 00:32:06,590
+warranty the buyer will not be able to reject the
+
+467
+00:32:06,590 --> 00:32:10,050
+contract the
+
+468
+00:32:10,050 --> 00:32:12,990
+only thing we can do in this case is applying for
+
+469
+00:32:12,990 --> 00:32:17,070
+money damages compensation compensation this
+
+470
+00:32:17,070 --> 00:32:19,150
+there's one sentence here a little bit difficult
+
+471
+00:32:19,150 --> 00:32:21,630
+but just i'm gonna explain it in any way i will
+
+472
+00:32:21,630 --> 00:32:27,960
+have to explain it hereجوان ديلي ولا ايه؟ هيا جوان
+
+473
+00:32:27,960 --> 00:32:33,780
+I don't know the name داليا او اعتدال؟ اعتدال this
+
+474
+00:32:33,780 --> 00:32:38,040
+amendment directs a traditionally strict approach
+
+475
+00:32:38,040 --> 00:32:41,280
+of English law جوان again again again this
+
+476
+00:32:41,280 --> 00:32:45,920
+amendment directs a traditionally strict approach
+
+477
+00:32:45,920 --> 00:32:49,660
+of English law to be practiced in a commercial
+
+478
+00:32:49,660 --> 00:32:56,310
+context it's amendment it meansيعني في الماضي
+
+479
+00:32:56,310 --> 00:33:01,750
+لدينا شيء آخر هذا شيء جديد اليوم شيء لدينا اليوم
+
+480
+00:33:01,750 --> 00:33:05,970
+في هذه القوة المحددة إذا كان لدينا فرق في الوارنتي
+
+481
+00:33:05,970 --> 00:33:12,510
+إذا كان لدينا فرق في الوارنتي فلن نستطيع أن نفرق
+
+482
+00:33:12,510 --> 00:33:17,330
+المشروع إنه وارنتي ليس شيء مهم لا يمكنني أن أفرقه
+
+483
+00:33:17,330 --> 00:33:20,150
+لا يمكنني أن أطلب من المال احتجاز لكن في السنة
+
+484
+00:33:20,150 --> 00:33:27,810
+الماضية هذه القوةهذا التعديل الجديد مدير التجارب
+
+485
+00:33:27,810 --> 00:33:34,750
+التقليدية في الماضي تتجارب تجارب التجارب التقليدية
+
+486
+00:33:34,750 --> 00:33:36,730
+في الماضي تتجارب تجارب التجارب التقليدية في الماضي
+
+487
+00:33:36,730 --> 00:33:36,730
+تتجارب تجارب التجارب التقليدية في الماضي تتجارب
+
+488
+00:33:36,730 --> 00:33:36,730
+تجارب التجارب التقليدية في الماضي تتجارب تجارب
+
+489
+00:33:36,730 --> 00:33:37,170
+التجارب التقليدية في الماضي تتجارب تجارب التجارب
+
+490
+00:33:37,170 --> 00:33:37,970
+التقليدية في الماضي تتجارب تجارب التجارب التقليدية
+
+491
+00:33:37,970 --> 00:33:43,610
+في الماضي تتجارب تجارب التجارب التقليدية في الماضي
+
+492
+00:33:43,610 --> 00:33:51,150
+تتجارب تجارب التجارب التقليدية في الماضي ت
+
+493
+00:33:51,510 --> 00:33:53,610
+إذا كنا نستطيع أن نحصل على بعض الاحتياطات، كل شيء
+
+494
+00:33:53,610 --> 00:33:57,710
+سيكون بخير، لماذا يجب أن نتخلص كل شيء، إذا كنا
+
+495
+00:33:57,710 --> 00:34:03,570
+نستطيع أن نتخلص بعض الوارنتيز، بعض التعاملات، وكل
+
+496
+00:34:03,570 --> 00:34:06,250
+شيء سيكون بخير، الآن القوة الجديدة ستنظر إلى
+
+497
+00:34:06,250 --> 00:34:11,950
+الاحتياطات، لكلا الجانحين، شرطي وصالح، نستطيع
+
+498
+00:34:11,950 --> 00:34:13,610
+الحصول على الاحتياطات، نستطيع الحصول على الميزة
+
+499
+00:34:13,610 --> 00:34:17,540
+والعقل والتوازنبين الانتصارين الاثنين ثم لا يوجد
+
+500
+00:34:17,540 --> 00:34:22,380
+نقطة لإنهاء الوضع أو تغييره ثم يجب أن نبقى ذلك
+
+501
+00:34:22,380 --> 00:34:28,480
+حسنا؟ انظر الآن إلى بعض التعاملات بعض التعاملات
+
+502
+00:34:28,480 --> 00:34:34,560
+انظر للقسم 12 والقسم 14 من عام 1979 وانظر واحد
+
+503
+00:34:34,560 --> 00:34:38,280
+منهم هو يجب أن ننظر الآن إلى مصدر القوة
+
+504
+00:34:39,700 --> 00:34:44,160
+description, sale by sample and so on and so forth
+
+505
+00:34:44,160 --> 00:34:48,800
+let's begin with implied term as to title title
+
+506
+00:34:48,800 --> 00:34:54,940
+what title is title of the property هو سند الملكية
+
+507
+00:34:54,940 --> 00:34:59,200
+يعني ملكية الشيء now this title we are talking
+
+508
+00:34:59,200 --> 00:35:03,780
+listen look at meLook, I'm not talking about
+
+509
+00:35:03,780 --> 00:35:07,060
+explicit terms in the contract I'm talking about
+
+510
+00:35:07,060 --> 00:35:14,720
+terms in the 1979 act, here, title This
+
+511
+00:35:14,720 --> 00:35:19,600
+is explicit term in the act, but at the same time
+
+512
+00:35:19,600 --> 00:35:24,140
+this is implicit in contract ان هو صريح في القانون
+
+513
+00:35:24,140 --> 00:35:28,520
+ضمن في العملfine؟ now this title هو الملكي ت الشيء
+
+514
+00:35:28,520 --> 00:35:32,220
+like selling you my house or my car selling you
+
+515
+00:35:32,220 --> 00:35:35,120
+some items which we have I would have to transfer
+
+516
+00:35:35,120 --> 00:35:39,260
+the title الملكي ت الشيء I would have to transfer
+
+517
+00:35:39,260 --> 00:35:42,220
+the title of somebody if I own this computer and I
+
+518
+00:35:42,220 --> 00:35:45,220
+have to pass it to you it has to be mine if it's
+
+519
+00:35:45,220 --> 00:35:48,260
+not mine I will not be able to sell I cannot sell
+
+520
+00:35:48,260 --> 00:35:51,280
+a mobile phone I have if it's not my mobile phone
+
+521
+00:35:51,280 --> 00:35:56,190
+I would have to own the propertyto be able to pass
+
+522
+00:35:56,190 --> 00:35:59,430
+it to anyone else so the title has to be my title
+
+523
+00:35:59,430 --> 00:36:02,990
+then I would have to pass it to حنين or to دي دي
+
+524
+00:36:02,990 --> 00:36:09,450
+or anyone else now section 12 section 12 in 1979
+
+525
+00:36:09,450 --> 00:36:14,610
+act what does it say ماشتها
+
+526
+00:36:14,610 --> 00:36:19,470
+can you read it section 12سيكتشن 12 يتعامل مع
+
+527
+00:36:19,470 --> 00:36:22,770
+التعامل اللي يتعامل مع التعامل اللي يتعامل مع
+
+528
+00:36:22,770 --> 00:36:23,310
+التعامل اللي يتعامل مع التعامل اللي يتعامل مع
+
+529
+00:36:23,310 --> 00:36:26,450
+التعامل اللي يتعامل مع التعامل اللي يتعامل مع
+
+530
+00:36:26,450 --> 00:36:27,890
+التعامل اللي يتعامل مع التعامل اللي يتعامل مع
+
+531
+00:36:27,890 --> 00:36:28,350
+التعامل اللي يتعامل مع التعامل اللي يتعامل مع
+
+532
+00:36:28,350 --> 00:36:28,470
+التعامل اللي يتعامل مع التعامل اللي يتعامل مع
+
+533
+00:36:28,470 --> 00:36:31,070
+التعامل اللي يتعامل مع التعامل اللي يتعامل مع
+
+534
+00:36:31,070 --> 00:36:34,930
+التعامل اللي يتعامل مع التعامل اللي يتعامل مع
+
+535
+00:36:34,930 --> 00:36:40,690
+التعامل اللي يتعامل مع التعامل اللي
+
+536
+00:36:40,690 --> 00:36:44,710
+يعندما تقوم بإعادة إسم لشخص آخر، إذا كنت ترغب في
+
+537
+00:36:44,710 --> 00:36:49,330
+تسليم أشياء جيدة لشخص آخر، فيجب أن تكون لديك إسم
+
+538
+00:36:49,330 --> 00:36:51,990
+لذلك الأشياء. إذا لم تكن لديك إسم لها، هل يمكنك
+
+539
+00:36:51,990 --> 00:36:56,610
+تسليمه؟ هل يمكنك تسليم أي شيء لا تملكه؟ لا. هل
+
+540
+00:36:56,610 --> 00:37:00,570
+يمكنك تسليم سيارتي؟ لا، لأنها ليست لك. إسمي هو لي،
+
+541
+00:37:00,570 --> 00:37:05,250
+هي سيارتي. ثم القواعد تقول أن يجب أن تكون لديك هذا
+
+542
+00:37:05,250 --> 00:37:11,080
+الوضعyou have to have the title title هي seller
+
+543
+00:37:11,080 --> 00:37:15,400
+either has legal title to the property either at
+
+544
+00:37:15,400 --> 00:37:19,840
+the time when you make the contract or at the time
+
+545
+00:37:19,840 --> 00:37:25,020
+when you pass the property الشيء نفسه goods so
+
+546
+00:37:25,020 --> 00:37:28,980
+either one of two يعني إما وقت العقد أو وقت
+
+547
+00:37:28,980 --> 00:37:33,660
+التسليم you have to have the title of the goodsفي
+
+548
+00:37:33,660 --> 00:37:36,440
+الوقت .. إما في الوقت عندما نفعل التقرير .. دعنا
+
+549
+00:37:36,440 --> 00:37:41,140
+نقول أن اليوم .. اليوم نفعل التقرير ولكن الوصول
+
+550
+00:37:41,140 --> 00:37:45,020
+سيكون بعد أسبوع أسبوع. لذا، لا مشكلة إذا كانت لديك
+
+551
+00:37:45,020 --> 00:37:48,900
+التقرير اليوم أو بعد أسبوع أسبوع. إذا أشتريت منك
+
+552
+00:37:48,900 --> 00:37:53,300
+50 كيلو جرام من الضوء
+
+553
+00:37:55,150 --> 00:38:00,530
+و قلت أني سأعطيك هذا بعد خمس أيام لا أهتم إذا كان
+
+554
+00:38:00,530 --> 00:38:03,830
+لديك الأمر الآن أو بعد أربع أيام أو خمس أيام، فلكن
+
+555
+00:38:03,830 --> 00:38:07,770
+بعد خمس أيام أستطيع أن أحصل على الأشياء التي أحصل
+
+556
+00:38:07,770 --> 00:38:09,950
+عليها، أشيائي التي أحصل عليها. لذلك، يمكنك أن تكون
+
+557
+00:38:09,950 --> 00:38:12,990
+لديك المصطلح في الوقت الذي يجب أن يتم إصلاحه، وقت
+
+558
+00:38:12,990 --> 00:38:16,090
+توقيع العقل في الوقت الذي يجب أن يتم إصلاحه أو في
+
+559
+00:38:16,090 --> 00:38:21,190
+الوقت عندما يتم تحوير الحيواناتو هذا يحدث بشكل
+
+560
+00:38:21,190 --> 00:38:25,290
+عادى في حياتنا و انت ترى ان انا اعرف ان بعض الناس
+
+561
+00:38:25,290 --> 00:38:30,210
+اللي بيعوض اشياء من شينا او ايجابس او تركيا بيعوض
+
+562
+00:38:30,210 --> 00:38:33,750
+المال قبلها انا لا اعرف اذا هذا قانوني في الإسلام
+
+563
+00:38:33,750 --> 00:38:38,330
+او ليس قانوني هذا لكن بيعوض شيء يجب ان تكون متأكد
+
+564
+00:38:38,330 --> 00:38:41,910
+انك تبقى متأكد انك تبقى متأكد انك تبقى متأكد انك
+
+565
+00:38:41,910 --> 00:38:42,690
+تبقى متأكد انك تبقى متأكد انك تبقى متأكد انك تبقى
+
+566
+00:38:42,690 --> 00:38:44,370
+متأكد انك تبقى متأكد انك تبقى متأكد انك تبقى متأكد
+
+567
+00:38:44,370 --> 00:38:47,050
+انك تبقى متأكد انك
+
+568
+00:38:49,090 --> 00:38:55,450
+the corpse before it's before it's been harvested
+
+569
+00:38:55,450 --> 00:38:59,830
+you get one point what I'm saying؟ the corpse you
+
+570
+00:38:59,830 --> 00:39:01,870
+cannot buy before it's harvested يعني قبل جنيه
+
+571
+00:39:01,870 --> 00:39:05,890
+الثمار مش ممكن after you harvest it then we can't
+
+572
+00:39:05,890 --> 00:39:10,470
+buy itثم نفس الشيء هنا لا هنا ليس كذلك لازم نتأكد
+
+573
+00:39:10,470 --> 00:39:15,710
+ان انا اعطيك المال او نشتري شرط لشيء سوف تسحبه لي
+
+574
+00:39:15,710 --> 00:39:19,890
+ثم يجب أن تكون لديك اسم عندما نشتري الشرط او ربما
+
+575
+00:39:19,890 --> 00:39:25,730
+بعد 5 او 4 او 6 أيام كم ان هذا يمكن ان يتم فعله
+
+576
+00:39:25,730 --> 00:39:32,570
+عند وصوله عندما نقوم باستخدام اسم لان بعض الشركات
+
+577
+00:39:32,570 --> 00:39:39,560
+تحصل على المالللشباب يحصلوا يحصلوا يحصلوا يحصلوا
+
+578
+00:39:39,560 --> 00:39:40,980
+يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا
+
+579
+00:39:40,980 --> 00:39:40,980
+يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا
+
+580
+00:39:40,980 --> 00:39:41,700
+يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا
+
+581
+00:39:41,700 --> 00:39:41,720
+يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا
+
+582
+00:39:41,720 --> 00:39:42,940
+يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا
+
+583
+00:39:42,940 --> 00:39:44,460
+يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا
+
+584
+00:39:44,460 --> 00:39:45,960
+يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا يحصلوا
+
+585
+00:39:45,960 --> 00:39:57,120
+يحصلوا يحصل
+
+586
+00:40:03,940 --> 00:40:09,780
+خلاص هذا هو الوضع لذلك لا نستطيع نقل شيء لا نملكه
+
+587
+00:40:09,780 --> 00:40:12,120
+و ورانتيز نحن لدينا في نفس الوقت نحن لدينا 2
+
+588
+00:40:12,120 --> 00:40:16,800
+ورانتيز 2 ورانتيز لذا هذه هي الأشياء الأساسية هذه
+
+589
+00:40:16,800 --> 00:40:21,060
+هي الأشياء المهمة أكتر لدي 50 كلابتوب أريد أن أقوم
+
+590
+00:40:21,060 --> 00:40:24,140
+بتقليلك لدي سيارة أريد أن أقوم بتقليلها لسيارتي
+
+591
+00:40:24,140 --> 00:40:28,780
+هذه السيارة في اسمي اسمي وانا يجب أن أعطيها لك وهو
+
+592
+00:40:28,780 --> 00:40:35,610
+بخير ولكن لدينا 2 ورانتيز إضافيةفى يعني فى شروق
+
+593
+00:40:35,610 --> 00:40:38,390
+إضافية by law by the nineteen seventy nine يعني
+
+594
+00:40:38,390 --> 00:40:45,890
+this one of them is .. one of them is ..
+
+595
+00:40:45,890 --> 00:40:51,410
+position position
+
+596
+00:40:51,410 --> 00:40:57,930
+هو ملكية هادئة okay
+
+597
+00:41:03,390 --> 00:41:06,050
+no no that's fine that's fine these two warranties
+
+598
+00:41:06,050 --> 00:41:12,290
+saying that once the seller passing the title to
+
+599
+00:41:12,290 --> 00:41:16,870
+someone else at that time this title has to be
+
+600
+00:41:16,870 --> 00:41:20,810
+free from any incomprehensives يعني خالي من أي قيد
+
+601
+00:41:20,810 --> 00:41:25,650
+free I can transfer the land the goods the item
+
+602
+00:41:25,650 --> 00:41:29,430
+anything I have to someone else now free from any
+
+603
+00:41:29,430 --> 00:41:33,100
+incomprehensives مافيش قيدno restriction nothing
+
+604
+00:41:33,100 --> 00:41:37,760
+and having a quiet position ملكية هادة so no one
+
+605
+00:41:37,760 --> 00:41:40,960
+else can come in the future asking you well
+
+606
+00:41:40,960 --> 00:41:44,540
+disputing that this item belongs to someone else
+
+607
+00:41:44,540 --> 00:41:48,580
+so this item have to be passed from a to b a to b
+
+608
+00:41:48,580 --> 00:41:52,760
+and no c would claim it no one else can claim it
+
+609
+00:41:52,760 --> 00:41:58,980
+it's only a having the title passed to bif we have
+
+610
+00:41:58,980 --> 00:42:02,400
+a dispute on that title on that commodity between
+
+611
+00:42:02,400 --> 00:42:05,540
+two more than two people then it's not a quiet
+
+612
+00:42:05,540 --> 00:42:08,880
+position sometimes you have lien something called
+
+613
+00:42:08,880 --> 00:42:12,520
+third party having lien over the goods what lien
+
+614
+00:42:12,520 --> 00:42:17,360
+اللي هو الرهن أو الحجز رهن some people what they
+
+615
+00:42:17,360 --> 00:42:20,980
+do they get money and the money they get them from
+
+616
+00:42:20,980 --> 00:42:25,300
+banks from banks or from building societies but
+
+617
+00:42:25,300 --> 00:42:29,500
+what they do they havesomething as a mortgage
+
+618
+00:42:29,500 --> 00:42:35,580
+بنظام الرهن القارن mortgage so having lien over
+
+619
+00:42:35,580 --> 00:42:38,560
+the house or the land or the flat or the car
+
+620
+00:42:38,560 --> 00:42:42,740
+having lien over over the title it means I cannot
+
+621
+00:42:42,740 --> 00:42:46,560
+sell I cannot transfer that title freely because
+
+622
+00:42:46,560 --> 00:42:49,840
+someone else would have his hand on that title
+
+623
+00:42:49,840 --> 00:42:53,240
+someone else would come first to claim it someone
+
+624
+00:42:53,240 --> 00:42:56,180
+would claim it then this is not it's not a free
+
+625
+00:42:56,760 --> 00:43:00,240
+then we have some restriction then he would cause
+
+626
+00:43:00,240 --> 00:43:04,020
+trouble by this by this here we have to make sure
+
+627
+00:43:04,020 --> 00:43:09,200
+that once we transfer the title to the buyer he or
+
+628
+00:43:09,200 --> 00:43:12,780
+she would have it quietly with no dispute from
+
+629
+00:43:12,780 --> 00:43:17,560
+anyone else okay this this one point here as you
+
+630
+00:43:17,560 --> 00:43:21,960
+can see in small lines this term for some some
+
+631
+00:43:21,960 --> 00:43:25,980
+schoolersبعض المدرسات تقول ان هذه الكلمات ممكن
+
+632
+00:43:25,980 --> 00:43:31,980
+تكون عظيمة ممكن تكون صعبة لشخص واحد مثلا هل يمكن
+
+633
+00:43:31,980 --> 00:43:36,480
+أحد يرىها؟ هل يمكنك أن ترىها؟ نعم لماذا؟ لماذا؟ في
+
+634
+00:43:36,480 --> 00:43:40,960
+المرة القادمة؟ نعم في المرة القادمة نفس الوقت نفس
+
+635
+00:43:40,960 --> 00:43:41,840
+الوقت نفس الوقت نفس الوقت نفس الوقت نفس الوقت نفس
+
+636
+00:43:41,840 --> 00:43:42,180
+الوقت نفس الوقت نفس الوقت نفس الوقت نفس الوقت نفس
+
+637
+00:43:42,180 --> 00:43:42,540
+الوقت نفس الوقت نفس الوقت نفس الوقت نفس الوقت نفس
+
+638
+00:43:42,540 --> 00:43:42,560
+الوقت نفس الوقت نفس الوقت نفس الوقت نفس الوقت نفس
+
+639
+00:43:42,560 --> 00:43:47,820
+الوقت نفس الوقت نفس الوقت نفس الوقت نفس الوقت نفس
+
+640
+00:43:47,820 --> 00:43:56,080
+الوقت نفس الأنا أرى .. أرى أفضل أن تأتي للدراسة
+
+641
+00:43:56,080 --> 00:44:00,020
+لتقضي الدراسة هنا يمكنك أن تسمعني، يمكننا أن
+
+642
+00:44:00,020 --> 00:44:02,920
+نتكلم، يمكننا أن نشرح لأن إذا كنت ترغب في تدرس هذه
+
+643
+00:44:02,920 --> 00:44:08,440
+النقطة في الكتاب كالـR هنا، سيكون صعب التفكير في
+
+644
+00:44:08,440 --> 00:44:12,540
+معرفة المعنى و ستترجمه إلى معنى مختلفة، لذلك من
+
+645
+00:44:12,540 --> 00:44:15,880
+الجيد أن تقضي الدراسة و تأخذ بعض التقاط الأولى
+
+646
+00:44:15,880 --> 00:44:19,620
+الثانوية الثانوية الثانوية الثانوية هنا تقول إن
+
+647
+00:44:19,620 --> 00:44:22,820
+كان لدينا مخططوهذه المقالات التي قام بها قائد
+
+648
+00:44:22,820 --> 00:44:26,600
+الويلف او البرنامج او المصطلح اذا كان لديه مصطلح
+
+649
+00:44:26,600 --> 00:44:31,720
+اذا انا اشتري شيء من شخص ما و انا اجد المسلسل
+
+650
+00:44:31,720 --> 00:44:37,020
+اشتري المصطلح لا مصطلح او المصطلح لم يكن مجانا اذا
+
+651
+00:44:37,020 --> 00:44:41,200
+كنت اخذ المال مني و هو يأخذ المواد منك مرة أخرى
+
+652
+00:44:41,200 --> 00:44:47,250
+كبائع كبائع انا استطيع اخذ المال مني او لا؟and the
+
+653
+00:44:47,250 --> 00:44:50,150
+seller who breached the contract وخالف العقد he
+
+654
+00:44:50,150 --> 00:44:53,610
+would take his goods back the problem is sometimes
+
+655
+00:44:53,610 --> 00:44:57,830
+the seller sorry the buyer taking the items here
+
+656
+00:44:57,830 --> 00:45:01,930
+the item and using it like I got the laptop got
+
+657
+00:45:01,930 --> 00:45:05,530
+fifty laptops and I used five of them I used them
+
+658
+00:45:05,530 --> 00:45:09,620
+they are not new anymoreثم أستطيع أن أخذ المال
+
+659
+00:45:09,620 --> 00:45:12,180
+مجددا و يستطيع الشرطة أن تأخذ حاجتها مجددا نفس
+
+660
+00:45:12,180 --> 00:45:15,720
+الشيء مع السيارة أو المطعم أو أي شيء مثل هذا أنا
+
+661
+00:45:15,720 --> 00:45:20,660
+كنت أستخدم الحاجات الأشياء ثم بعد عدة أيام أو عدة
+
+662
+00:45:20,660 --> 00:45:24,640
+أسابق أخذت المال مجددا و الشرطة أخذت حاجتها مجددا
+
+663
+00:45:24,640 --> 00:45:28,980
+هل يجب أن أدفع الوقت اللي قمت بإستخدام الأشياء أو
+
+664
+00:45:28,980 --> 00:45:34,000
+لا؟ ماذا تعتقد؟ بالفعل لا يجب أن تكون لأنه ليس
+
+665
+00:45:34,000 --> 00:45:39,460
+خطأي أنا كنت أفعل أفضل ما كنت أفعله بشكل جيدI paid
+
+666
+00:45:39,460 --> 00:45:44,360
+the money I committed myself but the seller did
+
+667
+00:45:44,360 --> 00:45:46,720
+not commit himself did not follow the whole
+
+668
+00:45:46,720 --> 00:45:49,720
+instructions and he was doing something wrong he
+
+669
+00:45:49,720 --> 00:45:52,560
+was breaching the contract then I can take my
+
+670
+00:45:52,560 --> 00:45:56,040
+money back and he can take his goods back but I
+
+671
+00:45:56,040 --> 00:45:58,300
+would not compensate as a buyer will not
+
+672
+00:45:58,300 --> 00:46:01,120
+compensate the seller for the time I used the
+
+673
+00:46:01,120 --> 00:46:05,000
+items some some scholars say well this is not fair
+
+674
+00:46:06,690 --> 00:46:09,150
+that's that's an opinion it's up to you you can
+
+675
+00:46:09,150 --> 00:46:11,750
+think about it we have different opinions on life
+
+676
+00:46:11,750 --> 00:46:14,310
+some people believe this is the situation this is
+
+677
+00:46:14,310 --> 00:46:17,070
+fine this is perfect others say well this is not
+
+678
+00:46:17,070 --> 00:46:19,810
+perfect this is not fair because as long as you
+
+679
+00:46:19,810 --> 00:46:22,490
+have been using those items you have to pay for
+
+680
+00:46:22,490 --> 00:46:25,030
+that like imagine yourself that you are hiring
+
+681
+00:46:25,030 --> 00:46:30,530
+renting بالإيجار يعني استأجر renting a car and not
+
+682
+00:46:31,120 --> 00:46:34,880
+now after I use the car for 10 days or 20 days I'm
+
+683
+00:46:34,880 --> 00:46:37,380
+taking it back to its owner and taking my money
+
+684
+00:46:37,380 --> 00:46:41,720
+back now as I said you have two opinions one says
+
+685
+00:46:41,720 --> 00:46:44,780
+it's fine you should not pay anything this is by
+
+686
+00:46:44,780 --> 00:46:48,220
+law this is the legal point I should not pay
+
+687
+00:46:48,220 --> 00:46:50,800
+anything I can take my money back as a buyer and
+
+688
+00:46:50,800 --> 00:46:53,280
+the seller can take the item some schoolers say
+
+689
+00:46:53,280 --> 00:46:57,520
+some some schoolers protests protest against this
+
+690
+00:46:57,520 --> 00:47:02,380
+يحتجوا saying well this is not fairحسنا دعونا
+
+691
+00:47:02,380 --> 00:47:08,140
+نتحرك للموضوع التالي هذا
+
+692
+00:47:08,140 --> 00:47:16,160
+موضوع سهل هنا انها سائل باسم سائل باسم مرة أخرى
+
+693
+00:47:16,160 --> 00:47:26,720
+أولا كانت اسم و الأن اسم هنا اسم سائل باسم نجد
+
+694
+00:47:26,720 --> 00:47:31,320
+أشياءwith the whole description stated in the
+
+695
+00:47:31,320 --> 00:47:36,320
+contract this description here were agreed between
+
+696
+00:47:36,320 --> 00:47:39,860
+a and b sometimes when you buy when you buy some
+
+697
+00:47:39,860 --> 00:47:44,660
+items from some some online online stores like
+
+698
+00:47:44,660 --> 00:47:49,140
+when you go to deal deal company you know it deal
+
+699
+00:47:49,140 --> 00:47:53,800
+if you would like to buy a laptop or pc you go to
+
+700
+00:47:53,800 --> 00:47:57,240
+the website to the main page you can select the
+
+701
+00:47:57,240 --> 00:48:03,320
+itemاو اذا كنت ترغب ان تبني اشياء تبنيها نفسك
+
+702
+00:48:03,320 --> 00:48:09,360
+تختار اشياء
+
+703
+00:48:09,360 --> 00:48:15,240
+تبنيها نفسك تختار اشياء تبنيها نفسك تختار اشياء
+
+704
+00:48:15,240 --> 00:48:17,860
+تبنيها نفسك تختار اشياء تبنيها نفسك تختار اشياء
+
+705
+00:48:17,860 --> 00:48:18,400
+تبنيها نفسك تختار اشياء تبنيها نفسك تختار اشياء
+
+706
+00:48:18,400 --> 00:48:19,580
+تبنيها نفسك تختار اشياء تبنيها نفسك تختار اشياء
+
+707
+00:48:19,580 --> 00:48:20,220
+تبنيها نفسك تختار اشياء تبنيها نفسك تختار اشياء
+
+708
+00:48:20,220 --> 00:48:20,260
+تبنيها نفسك تختار اشياء تبنيها نفسك تختار اشياء
+
+709
+00:48:20,260 --> 00:48:22,340
+تبنيها نفسك تختار اشياء تبنيها نفسك تبني
+
+710
+00:48:25,050 --> 00:48:28,490
+then once you pay the money by visa card you
+
+711
+00:48:28,490 --> 00:48:32,070
+expect in a two days time .. two days time you
+
+712
+00:48:32,070 --> 00:48:35,190
+expect a laptop one week time you expect this
+
+713
+00:48:35,190 --> 00:48:40,450
+laptop is coming to your house by delivery then
+
+714
+00:48:40,450 --> 00:48:42,910
+you .. when you look at it you can .. you can
+
+715
+00:48:42,910 --> 00:48:47,900
+expect the same descriptionas you have stated and
+
+716
+00:48:47,900 --> 00:48:51,540
+you can imagine anything like this anything when
+
+717
+00:48:51,540 --> 00:48:53,440
+you buy a suit when you buy a head scarf when you
+
+718
+00:48:53,440 --> 00:48:56,660
+buy glasses a mobile phone when you buy sometimes
+
+719
+00:48:56,660 --> 00:49:00,820
+when you buy items like chairs like this here
+
+720
+00:49:00,820 --> 00:49:05,060
+buying them from china buying half a million half
+
+721
+00:49:05,060 --> 00:49:07,940
+a million chair like this you're gonna use them
+
+722
+00:49:07,940 --> 00:49:12,240
+for the public use half a million now it's not one
+
+723
+00:49:12,240 --> 00:49:16,670
+item or two buying by description herewe have to
+
+724
+00:49:16,670 --> 00:49:21,250
+make sure that everything is up to description we
+
+725
+00:49:21,250 --> 00:49:27,090
+have made بالتمام يعني perfectly with a buyer buys
+
+726
+00:49:27,090 --> 00:49:33,670
+goods by description then the goods must not not
+
+727
+00:49:33,670 --> 00:49:37,090
+have to must correspond with this with the
+
+728
+00:49:37,090 --> 00:49:41,770
+descriptionيجب أن يتوافق مثلًا إذا وجدت خطأ ليس
+
+729
+00:49:41,770 --> 00:49:44,030
+نفس التصفية يمكنني أن أخذها مرة أخرى يقول حسنًا
+
+730
+00:49:44,030 --> 00:49:49,150
+لقد قررت الموضوع ثم هل سنغيّر الموضوع؟ بالمناسبة
+
+731
+00:49:49,150 --> 00:49:54,510
+قبل أن ننتهي هذه القصة سنبحث عن حلوات إذا كانت
+
+732
+00:49:54,510 --> 00:49:58,910
+واحدة من هذه القرارات سيلر قرر الموضوع ماذا يمكن
+
+733
+00:49:58,910 --> 00:50:01,950
+أن يفعل الشرطة؟ سنبحث عن الحلوة المقبلة المقبلة
+
+734
+00:50:01,950 --> 00:50:03,450
+المقبلة المقبلة المقبلة المقبلة المقبلة المقبلة
+
+735
+00:50:03,450 --> 00:50:07,710
+المقبلة المقبلة المقبلة المقبلة المقبلة المقبلة
+
+736
+00:50:07,710 --> 00:50:08,170
+المقبلة المقبلة المقبلة المقبلة المقبلة المقبل
+
+737
+00:50:08,440 --> 00:50:13,180
+between two guys two men it's a legal precedent in
+
+738
+00:50:13,180 --> 00:50:16,660
+the UK that you know the system in the UK in
+
+739
+00:50:16,660 --> 00:50:22,900
+England Britain that's called Commonwealth we have
+
+740
+00:50:22,900 --> 00:50:29,740
+common law common law common law is based oh come
+
+741
+00:50:29,740 --> 00:50:33,220
+on we had it the first week civil law and common
+
+742
+00:50:33,220 --> 00:50:38,180
+law you forgotالعامة العامة تعتمد على قرارات
+
+743
+00:50:38,180 --> 00:50:44,260
+قانونية مسمى judge made law القانون مجرد judge
+
+744
+00:50:44,260 --> 00:50:49,200
+قرار مجرد judge قرار كقرار أستطيع أن أقوم بقرارات
+
+745
+00:50:49,200 --> 00:50:52,800
+و القرارات التي أقوم بها قرارات تستطيع أن تكون
+
+746
+00:50:52,800 --> 00:50:59,560
+مقارنة في المستقبل في نفس الحالات، في حالات مشابهة
+
+747
+00:50:59,560 --> 00:51:01,800
+تستطيع أن تكون مقارنة، نستطيع أن نستخدمها في
+
+748
+00:51:01,800 --> 00:51:06,540
+المستقبل في واحد من الحالاتit was said it was said
+
+749
+00:51:06,540 --> 00:51:10,620
+that this implied terms may only be preached
+
+750
+00:51:10,620 --> 00:51:15,380
+description only one case in one case we have to
+
+751
+00:51:15,380 --> 00:51:18,280
+apply one condition to make sure that will the
+
+752
+00:51:18,280 --> 00:51:22,680
+seller has preached the condition here he did not
+
+753
+00:51:22,680 --> 00:51:28,300
+pass me the item as stated in the contract here if
+
+754
+00:51:28,300 --> 00:51:32,840
+see the condition ifthe buyer as a buyer relied
+
+755
+00:51:32,840 --> 00:51:38,640
+upon the description that's one condition be
+
+756
+00:51:38,640 --> 00:51:42,160
+careful when you have a question in the exam in
+
+757
+00:51:42,160 --> 00:51:45,820
+point like this I have to make sure in this case
+
+758
+00:51:45,820 --> 00:51:48,780
+as a judge if I look at this case I would see if
+
+759
+00:51:48,780 --> 00:51:54,020
+the buyer was relying هو اعتمد بالكامل upon the
+
+760
+00:51:54,020 --> 00:51:56,900
+description because I wanted this laptop for
+
+761
+00:51:56,900 --> 00:52:01,770
+specific use and I make it clearللـ Seller ان انا
+
+762
+00:52:01,770 --> 00:52:06,830
+احب اشتري لابتوب لأحتياطات محددة و انا اخبره بشكل
+
+763
+00:52:06,830 --> 00:52:11,370
+واضح ان تلك التصميم 1,2,3,10,20 تصميم انا اريدها
+
+764
+00:52:11,370 --> 00:52:14,990
+في اللابتوب و اعتنق على الـ Seller و اخبرني ان
+
+765
+00:52:14,990 --> 00:52:21,050
+اللابتوب هو عرفه من البداية ان انا اريده لتصميم
+
+766
+00:52:21,050 --> 00:52:26,110
+محددة محددة الـ PairBus هل يمكنك أن تقرر هذه
+
+767
+00:52:26,110 --> 00:52:31,560
+النقطة هنا؟بالتالي، إذا كان المستخدم مستخدم، فإن
+
+768
+00:52:31,560 --> 00:52:33,940
+إعلانه لا يمكن أن يتم إصلاحه. انظر .. انظر ..
+
+769
+00:52:33,940 --> 00:52:38,300
+نستطيع .. الأن .. الأن .. إنها أشياء خاطئة، إنها
+
+770
+00:52:38,300 --> 00:52:40,100
+أشياء جيدة، إنها أشياء خاطئة جدًا، إنها أشياء
+
+771
+00:52:40,100 --> 00:52:41,440
+جيدة، إنها أشياء جيدة، إنها أشياء جيدة، إنها أشياء
+
+772
+00:52:41,440 --> 00:52:43,380
+جيدة، إنها أشياء جيدة، إنها أشياء جيدة، إنها أشياء
+
+773
+00:52:43,380 --> 00:52:43,940
+جيدة، إنها أشياء جيدة، إنها أشياء جيدة، إنها أشياء
+
+774
+00:52:43,940 --> 00:52:51,780
+جيدة، إنها أشياء جيدة، إنها أشياء جيدة، إنها
+
+775
+00:52:51,780 --> 00:52:58,290
+أشياء جيدة، إنها200 هاتف موبايل نوكيا من إنديا
+
+776
+00:52:58,290 --> 00:53:07,650
+يأتي إلى غازا هنا إذا كنت اعتمد على السيلر و إذا
+
+777
+00:53:07,650 --> 00:53:11,030
+كنت عارف من البداية أنني أريد هؤلاء الهاتف
+
+778
+00:53:11,030 --> 00:53:16,870
+الموبايل لشركات معينة ثم هؤلاء الهاتف الموبايل يجب
+
+779
+00:53:16,870 --> 00:53:24,840
+أن يتوافق معه سيكون مثل ما ذكرناunless in one case
+
+780
+00:53:24,840 --> 00:53:29,280
+we cannot use reliance اللي هو الاعتماد يعني as a
+
+781
+00:53:29,280 --> 00:53:33,360
+buyer sometimes as a buyer I cannot establish the
+
+782
+00:53:33,360 --> 00:53:37,840
+fact that I made it clear to the seller I cannot
+
+783
+00:53:37,840 --> 00:53:41,000
+establish this fact by saying to the judge well he
+
+784
+00:53:41,000 --> 00:53:43,880
+was listening to me and I made it clear to him
+
+785
+00:53:43,880 --> 00:53:49,040
+that I want those specifications because if the
+
+786
+00:53:49,040 --> 00:53:53,350
+buyer is an expertإذا كنت مستخدم، إذا كنت أعرف
+
+787
+00:53:53,350 --> 00:53:58,030
+الأشياء، إذا كنت أعرف المصطلحات في هذه الحالة هنا،
+
+788
+00:53:58,030 --> 00:54:00,790
+لا يمكن أن يكون هناك اعتماد لا يمكن أن يكون هناك
+
+789
+00:54:00,790 --> 00:54:03,390
+اعتماد، لذا يكون هناك اعتماد اعتماد على من؟ على
+
+790
+00:54:03,390 --> 00:54:05,770
+البائع المشتري اعتمد على البائع المشتري اعتمد على
+
+791
+00:54:05,770 --> 00:54:07,510
+البائع المشتري اعتمد على البائع المشتري اعتمد على
+
+792
+00:54:07,510 --> 00:54:09,050
+البائع المشتري اعتمد على البائع المشتري اعتمد على
+
+793
+00:54:09,050 --> 00:54:09,870
+البائع المشتري اعتمد على البائع المشتري اعتمد على
+
+794
+00:54:09,870 --> 00:54:16,250
+البائع المشتري اعتمد
+
+795
+00:54:16,250 --> 00:54:20,050
+على البائع المشتري اعتمد على البائع المشتري اعتمد
+
+796
+00:54:20,050 --> 00:54:23,100
+على البائع المشتري اis expert and he knows
+
+797
+00:54:23,100 --> 00:54:26,640
+everything about the items and he should not rely
+
+798
+00:54:26,640 --> 00:54:32,740
+upon the description made by by the seller then he
+
+799
+00:54:32,740 --> 00:54:35,680
+cannot claim later on he cannot claim that well I
+
+800
+00:54:35,680 --> 00:54:39,380
+didn't know it's you from the beginning that you
+
+801
+00:54:39,380 --> 00:54:42,920
+knew those description like if I was myself as a
+
+802
+00:54:42,920 --> 00:54:47,400
+computer engineer computer engineer I know very
+
+803
+00:54:47,400 --> 00:54:50,980
+well about computers and I examined the computerفي
+
+804
+00:54:50,980 --> 00:54:56,080
+الوقت اللي اشتريته اتفقدته وكل شيء بخير على الرغم
+
+805
+00:54:56,080 --> 00:54:59,720
+من الحقيقة ان السيلر أعطىني بعض التصريحات
+
+806
+00:55:02,300 --> 00:55:05,040
+I should not rely on what he said to me because I
+
+807
+00:55:05,040 --> 00:55:08,220
+can examine it I can look at it I can see if this
+
+808
+00:55:08,220 --> 00:55:12,840
+computer is good or not I'm you know I'm educated
+
+809
+00:55:12,840 --> 00:55:16,180
+I have skills I have knowledge experience in
+
+810
+00:55:16,180 --> 00:55:20,000
+computers then why should I rely upon what the
+
+811
+00:55:20,000 --> 00:55:23,320
+seller has told me then in this case I would use
+
+812
+00:55:23,320 --> 00:55:26,940
+my mind and my knowledge then even if I did not
+
+813
+00:55:26,940 --> 00:55:31,430
+find in the item the same specificationsas the
+
+814
+00:55:31,430 --> 00:55:34,770
+seller has stated it will be my mistake because
+
+815
+00:55:34,770 --> 00:55:39,150
+I'm expert in this subject fine هيجيه لك؟ is it
+
+816
+00:55:39,150 --> 00:55:48,230
+okay حنين are you sure okay quality
+
+817
+00:55:48,230 --> 00:55:51,350
+is
+
+818
+00:55:51,350 --> 00:55:56,090
+it the eighth week this week this is the eighth
+
+819
+00:55:56,090 --> 00:56:00,980
+week of this semester eighth weekسبوع التام يعني
+
+820
+00:56:00,980 --> 00:56:04,960
+.. is that .. okay now we have to move to the
+
+821
+00:56:04,960 --> 00:56:11,860
+quality .. quality or fitness .. quality of
+
+822
+00:56:11,860 --> 00:56:18,380
+fitness .. او fill up .. yeah .. quality of
+
+823
+00:56:18,380 --> 00:56:25,580
+fitness .. these terms هي quality .. fitness will
+
+824
+00:56:25,580 --> 00:56:27,800
+be applicable only when
+
+825
+00:56:30,490 --> 00:56:32,210
+سنة و أربعة من سنة و أربعة و أربعة و أربعة و أربعة
+
+826
+00:56:32,210 --> 00:56:34,630
+و أربعة و أربعة و أربعة و أربعة و أربعة و أربعة و
+
+827
+00:56:34,630 --> 00:56:34,750
+أربعة و أربعة و أربعة و أربعة و أربعة و أربعة و
+
+828
+00:56:34,750 --> 00:56:40,330
+أربعة و أربعة و أربعة و أربعة و أربعة و أربعة و
+
+829
+00:56:40,330 --> 00:56:43,450
+أربعة و أربعة و أربعة و أربعة و أربعة و أربعة و
+
+830
+00:56:43,450 --> 00:56:44,090
+أربعة و أربعة و أربعة و أربعة و أربعة و أربعة و
+
+831
+00:56:44,090 --> 00:56:46,330
+أربعة و أربعة و أربعة و أربعة و أربعة و أربعة و
+
+832
+00:56:46,330 --> 00:56:46,870
+أربعة و أربعة و أربعة و أربعة و أربعة و أربعة و
+
+833
+00:56:46,870 --> 00:56:55,050
+أربعة و أربعة و أربعة و أربعة و أربعة و أربعة و
+
+834
+00:56:55,050 --> 00:57:00,090
+أربعة وis a business person then we can use
+
+835
+00:57:00,090 --> 00:57:07,510
+section 14 section 14 section 14 has two two sides
+
+836
+00:57:07,510 --> 00:57:13,610
+two divisions number one is fitness number two is
+
+837
+00:57:13,610 --> 00:57:20,850
+equality fitness for purpose fitness fit مناسب ولا
+
+838
+00:57:20,850 --> 00:57:23,090
+لأ fitness for purpose
+
+839
+00:57:26,240 --> 00:57:33,580
+انظر إلى هذا هنا يسمى white marker white board
+
+840
+00:57:33,580 --> 00:57:37,980
+marker هذا قلم نستطيع استخدامه على هذا الكمبيوتر
+
+841
+00:57:37,980 --> 00:57:42,940
+white board marker نستطيع استخدامه و بعدها نستطيع
+
+842
+00:57:42,940 --> 00:57:47,090
+تخلص ما لدينا نستطيع تنظيف الكمبيوترأنا أستطيع
+
+843
+00:57:47,090 --> 00:57:50,630
+استخدام هذا الوضع البيضاء على هذا الوضع البيضاء و
+
+844
+00:57:50,630 --> 00:57:53,670
+بعد أن ننتهي نستطيع ننظف نستطيع ننظف البيضاء، أليس
+
+845
+00:57:53,670 --> 00:57:59,030
+كذلك؟ نعم ولكن هناك بعض الوضع البيضاء يبقوا ..
+
+846
+00:57:59,030 --> 00:58:04,170
+يبقوا على البيضاء، لا يمكننا أن ننظفهم، أليس كذلك؟
+
+847
+00:58:04,170 --> 00:58:09,870
+سيكون صعب أن ننظفهم، لذلك يبدوا نفسهم، نفس الليلة،
+
+848
+00:58:09,870 --> 00:58:13,230
+نفس الشكل، نفس المال الذي يجب أن ندفعه، لكن الجودة
+
+849
+00:58:13,230 --> 00:58:17,700
+ليست الجودة التي نريدهاهو ليس الوضع الوضع الوضع
+
+850
+00:58:17,700 --> 00:58:21,480
+الوضع هنا هو أننا نستخدم هذه الوضع الوضع الوضع
+
+851
+00:58:21,480 --> 00:58:24,020
+الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع
+
+852
+00:58:24,020 --> 00:58:24,200
+الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع
+
+853
+00:58:24,200 --> 00:58:27,400
+الوضع الوضع الوضع
+
+854
+00:58:27,400 --> 00:58:33,160
+الوضع الوضع الوضع الوضع الوضع
+
+855
+00:58:33,160 --> 00:58:33,160
+الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع
+
+856
+00:58:33,160 --> 00:58:33,160
+الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع
+
+857
+00:58:33,160 --> 00:58:43,260
+الوضع الوضع الوضع الوضع الوضع الوض
+
+858
+00:58:43,840 --> 00:58:47,600
+have to deliver the items as stated exactly him
+
+859
+00:58:47,600 --> 00:58:51,020
+can you go on really حنين او لا if the buyer
+
+860
+00:58:51,020 --> 00:58:57,160
+expressly or impliedly makes
+
+861
+00:58:57,160 --> 00:59:01,460
+his purpose for the goods known to the seller okay
+
+862
+00:59:01,460 --> 00:59:05,760
+it has to be conditioned that the buyer have to
+
+863
+00:59:05,760 --> 00:59:10,540
+make it whether expressly or impliedly makes his
+
+864
+00:59:10,540 --> 00:59:17,770
+purposeهو استخدام هذه الأجهزة للمخزن بفعل هذا بفعل
+
+865
+00:59:17,770 --> 00:59:21,950
+هذا هنا المخزن مهتم يجب ان يجب ان يجب ان يجب ان
+
+866
+00:59:21,950 --> 00:59:25,190
+يجب ان يجب ان يجب ان يجب ان يجب ان يجب ان يجب ان
+
+867
+00:59:25,190 --> 00:59:25,270
+يجب ان يجب ان يجب ان يجب ان يجب ان يجب ان يجب ان
+
+868
+00:59:25,270 --> 00:59:25,310
+يجب ان يجب ان يجب ان يجب ان يجب ان يجب ان يجب ان
+
+869
+00:59:25,310 --> 00:59:25,310
+يجب ان يجب ان يجب ان يجب ان يجب ان يجب ان يجب ان
+
+870
+00:59:25,310 --> 00:59:26,110
+يجب ان يجب ان يجب ان يجب ان يجب ان يجب ان يجب ان
+
+871
+00:59:26,110 --> 00:59:26,110
+يجب ان يجب ان يجب ان يجب ان يجب ان يجب ان يجب ان
+
+872
+00:59:26,110 --> 00:59:26,110
+يجب ان يجب
+
+873
+00:59:40,320 --> 00:59:43,640
+هذه اللوحة بلو ولكن بعضهم عندما ترسم عليه على
+
+874
+00:59:43,640 --> 00:59:47,020
+المطبخ عندما ترسم عليه في اللوحة اللوحة اللوحة
+
+875
+00:59:47,020 --> 00:59:47,500
+اللوحة اللوحة اللوحة اللوحة اللوحة اللوحة اللوحة
+
+876
+00:59:47,500 --> 00:59:48,340
+اللوحة اللوحة اللوحة اللوحة اللوحة اللوحة اللوحة
+
+877
+00:59:48,340 --> 00:59:49,620
+اللوحة اللوحة اللوحة اللوحة اللوحة اللوحة اللوحة
+
+878
+00:59:49,620 --> 00:59:49,780
+اللوحة اللوحة اللوحة اللوحة اللوحة اللوحة اللوحة
+
+879
+00:59:49,780 --> 00:59:52,000
+اللوحة اللوحة اللوحة اللوحة اللوحة اللوحة اللوحة
+
+880
+00:59:52,000 --> 00:59:52,020
+اللوحة اللوحة اللوحة اللوحة اللوحة اللوحة اللوحة
+
+881
+00:59:52,020 --> 01:00:00,000
+اللوحة اللوحة اللوحة
+
+882
+01:00:00,570 --> 01:00:04,030
+الانفجارات الانفجارات العلوية لأن الملوك اللي
+
+883
+01:00:04,030 --> 01:00:06,490
+نستخدمه للانفجارات العلوية ليس نفس الملوك اللي
+
+884
+01:00:06,490 --> 01:00:10,270
+نستخدمه للورق لدينا مقالات مختلفة مقالات مختلفة
+
+885
+01:00:10,270 --> 01:00:13,690
+اشياء اشياء اشياء اشياء اشياء اشياء اشياء اشياء
+
+886
+01:00:13,690 --> 01:00:14,750
+اشياء اشياء اشياء اشياء اشياء اشياء اشياء اشياء
+
+887
+01:00:14,750 --> 01:00:14,750
+اشياء اشياء اشياء اشياء اشياء اشياء اشياء اشياء
+
+888
+01:00:14,750 --> 01:00:16,690
+اشياء اشياء اشياء اشياء اشياء اشياء اشياء اشياء
+
+889
+01:00:16,690 --> 01:00:27,030
+اشياء اشياء اشياء اشياء اشياء
+
+890
+01:00:28,040 --> 01:00:36,160
+which can fit the pair best as long as if it's
+
+891
+01:00:36,160 --> 01:00:40,280
+reasonable for the buyer to rely on the seller's
+
+892
+01:00:40,280 --> 01:00:44,900
+experience again we use a reliance الاعتماد as
+
+893
+01:00:44,900 --> 01:00:48,920
+long as the buyer using the seller he relying upon
+
+894
+01:00:48,920 --> 01:00:52,460
+him because I'm as a buyer myself I know Hanin if
+
+895
+01:00:52,460 --> 01:00:56,060
+you want to buy if you want to buy a paint you're
+
+896
+01:00:56,060 --> 01:00:59,100
+not an expertانت فقط اذهب للشبكة و اطلب من الشخص
+
+897
+01:00:59,100 --> 01:01:04,300
+اللي سيلر انا اريد ان اشتري .. اريد
+
+898
+01:01:04,300 --> 01:01:06,680
+ان اشتري مرحلات لان اريد ان اشتري مرحلات لان اريد
+
+899
+01:01:06,680 --> 01:01:07,720
+ان اشتري مرحلات لان اريد ان اشتري مرحلات لان اريد
+
+900
+01:01:07,720 --> 01:01:08,140
+ان اشتري مرحلات لان اريد ان اشتري مرحلات لان اريد
+
+901
+01:01:08,140 --> 01:01:08,140
+ان اشتري مرحلات لان اريد ان اشتري مرحلات لان اريد
+
+902
+01:01:08,140 --> 01:01:09,720
+ان اشتري مرحلات لان اريد ان اشتري مرحلات لان اريد
+
+903
+01:01:09,720 --> 01:01:14,700
+ان اشتري مرحلات لان اريد ان اشتري مرحلات
+
+904
+01:01:14,700 --> 01:01:20,980
+لان اريد
+
+905
+01:01:20,980 --> 01:01:21,620
+ان اشتري
+
+906
+01:01:28,550 --> 01:01:34,650
+the second is the quality .. quality .. quality
+
+907
+01:01:34,650 --> 01:01:38,790
+when you buy something you imagine that you would
+
+908
+01:01:38,790 --> 01:01:42,170
+have a quality when you buy a bottle of water even
+
+909
+01:01:42,170 --> 01:01:46,730
+even if it's a water you imagine it's clean it's
+
+910
+01:01:46,730 --> 01:01:52,130
+pure it's niceit tastes water not something else
+
+911
+01:01:52,130 --> 01:01:54,710
+you imagine that you would have equality when you
+
+912
+01:01:54,710 --> 01:01:57,650
+buy a head scarf you imagine that head scarf you
+
+913
+01:01:57,650 --> 01:02:00,590
+buy when you wash it for the first time would keep
+
+914
+01:02:00,590 --> 01:02:03,610
+the same color isn't it it's equality you expect
+
+915
+01:02:03,610 --> 01:02:07,250
+in any contract you make you can expect equality
+
+916
+01:02:07,250 --> 01:02:10,450
+same thing like with these pens here same thing
+
+917
+01:02:10,450 --> 01:02:12,730
+with a computer when you imagine that what kind of
+
+918
+01:02:12,730 --> 01:02:16,250
+equality it has to be satisfactory quality
+
+919
+01:02:16,250 --> 01:02:21,350
+satisfactoryشيء معقول يعني .. I cannot imagine
+
+920
+01:02:21,350 --> 01:02:24,230
+that this item would be the best in the world or
+
+921
+01:02:24,230 --> 01:02:26,310
+can be the worst in the world .. no it's something
+
+922
+01:02:26,310 --> 01:02:30,410
+reasonable .. something can be expected by a
+
+923
+01:02:30,410 --> 01:02:34,650
+reasonable person .. شيء معقول .. how can we know
+
+924
+01:02:34,650 --> 01:02:40,970
+that if it's reasonable or not .. the quality ..
+
+925
+01:02:40,970 --> 01:02:45,220
+who can decide .. two parties .. nowho can decide
+
+926
+01:02:45,220 --> 01:02:47,440
+if this quality the quality of this laptop this
+
+927
+01:02:47,440 --> 01:02:52,540
+mic if it's good if it's not who can decide if the
+
+928
+01:02:52,540 --> 01:02:58,600
+quality of the mic is the good quality the users
+
+929
+01:02:58,600 --> 01:03:04,280
+the app itself provides test objective test which
+
+930
+01:03:04,280 --> 01:03:09,040
+is said the quality would be expected by a
+
+931
+01:03:09,040 --> 01:03:13,140
+reasonable man or lady it's notالشرطة أو الشرطة
+
+932
+01:03:13,140 --> 01:03:17,860
+لأن إذا كانوا يتفاوضوا، فكل واحد يقول، يا عزيزي
+
+933
+01:03:17,860 --> 01:03:19,620
+الشرطة تقول، يا عزيزي الشرطة تقول، يا عزيزي الشرطة
+
+934
+01:03:19,620 --> 01:03:19,620
+تقول، يا عزيزي الشرطة تقول، يا عزيزي الشرطة تقول،
+
+935
+01:03:19,620 --> 01:03:20,880
+يا عزيزي الشرطة تقول، يا عزيزي الشرطة تقول، يا
+
+936
+01:03:20,880 --> 01:03:23,440
+عزيزي الشرطة تقول، يا عزيزي الشرطة تقول، يا عزيزي
+
+937
+01:03:23,440 --> 01:03:26,620
+الشرطة تقول، يا عزيزي الشرطة تقول، يا عزيزي الشرطة
+
+938
+01:03:26,620 --> 01:03:31,580
+تقول، يا عزيزي الشرطة تقول، يا عزيزي الشرطة تقول،
+
+939
+01:03:31,580 --> 01:03:40,040
+يا عزيزي
+
+940
+01:03:40,040 --> 01:03:43,790
+الشرطة تبالنسبة للقوة التي تحتوي عليها اذا اعطيت
+
+941
+01:03:43,790 --> 01:03:49,210
+2000$ اتوقع انه سيكون لديه قوة عالية اذا اعطيت 200
+
+942
+01:03:49,210 --> 01:03:52,570
+$ اتوقع ان هذا اللابتوب لاتكون له قوة عالية اذا
+
+943
+01:03:52,570 --> 01:03:52,950
+اعطيت 200$ اتوقع ان هذا اللابتوب لديه قوة عالية
+
+944
+01:03:52,950 --> 01:03:53,430
+اذا اعطيت 2000$ اتوقع ان هذا اللابتوب لديه قوة
+
+945
+01:03:53,430 --> 01:03:55,730
+عالية اتوقع ان هذا اللابتوب لديه قوة عالية اتوقع
+
+946
+01:03:55,730 --> 01:03:59,290
+ان هذا اللابتوب لديه قوة عالية اتوقع ان هذا
+
+947
+01:03:59,290 --> 01:04:05,020
+اللابتوب لديه قوة عاليةSome items we can expect to
+
+948
+01:04:05,020 --> 01:04:09,360
+have higher price and higher quality, other items
+
+949
+01:04:09,360 --> 01:04:13,060
+we can expect low quality and low price Like look
+
+950
+01:04:13,060 --> 01:04:15,580
+in the market now, what we have in Gaza, if you
+
+951
+01:04:15,580 --> 01:04:17,700
+buy something and you find it not good, you can
+
+952
+01:04:17,700 --> 01:04:21,860
+say oh well this was made in China, isn't it?But
+
+953
+01:04:21,860 --> 01:04:24,280
+in fact you see in china they manufacture
+
+954
+01:04:24,280 --> 01:04:27,640
+everything you like, they manufacture goods with
+
+955
+01:04:27,640 --> 01:04:30,320
+high quality and other goods with no quality at
+
+956
+01:04:30,320 --> 01:04:33,900
+all, it depends on the demands, on the request,
+
+957
+01:04:34,620 --> 01:04:37,960
+request for the buyers, for the buyers, in general
+
+958
+01:04:37,960 --> 01:04:40,100
+we have sometimes, sometimes things with high
+
+959
+01:04:40,100 --> 01:04:45,170
+quality, things with low qualitysecond hand goods
+
+960
+01:04:45,170 --> 01:04:49,170
+what second hand goods used مستعمل second hand
+
+961
+01:04:49,170 --> 01:04:52,210
+goods will attract lower price sorry lower
+
+962
+01:04:52,210 --> 01:04:55,030
+expectations when you buy .. when you buy a
+
+963
+01:04:55,030 --> 01:04:58,830
+computer and you know this is not new it's a used
+
+964
+01:04:58,830 --> 01:05:02,350
+it's second hand مش اليد التانية يعني هو same ..
+
+965
+01:05:02,350 --> 01:05:06,410
+same meaning second hand it's used you can expect
+
+966
+01:05:06,410 --> 01:05:08,610
+this is not the same quality like something new
+
+967
+01:05:08,610 --> 01:05:12,990
+when you buy a carit's not of course like what did
+
+968
+01:05:12,990 --> 01:05:15,230
+you buy second hand and you found it doesn't have
+
+969
+01:05:15,230 --> 01:05:19,370
+a quality mobile phone sometime you buy just a new
+
+970
+01:05:19,370 --> 01:05:22,350
+mobile phone and most likely people buying
+
+971
+01:05:22,350 --> 01:05:25,570
+secondhand mobile phones isn't it yeah but
+
+972
+01:05:25,570 --> 01:05:28,130
+something really nice but it's a secondhand
+
+973
+01:05:28,130 --> 01:05:31,350
+because if it's a new cost two thousand shekels
+
+974
+01:05:31,350 --> 01:05:33,910
+but if it's secondhand cost you only eight hundred
+
+975
+01:05:33,910 --> 01:05:37,900
+less than half of the priceولكن عندما تشتريه يجب
+
+976
+01:05:37,900 --> 01:05:42,740
+أن تتوقع أن هذا الأشياء ليس لديها نفس القوة لأن
+
+977
+01:05:42,740 --> 01:05:46,520
+إذا كانت .. كانت استخدامه من شخص آخر ربما كان لديه
+
+978
+01:05:46,520 --> 01:05:50,680
+بعض الخطوط ربما فقد فقدت القوة على أية حالة
+
+979
+01:05:50,680 --> 01:05:55,880
+الموضوع الثاني هو أن هناك بعض الأجهزة تستعمل هنا
+
+980
+01:05:55,880 --> 01:06:00,700
+تستعمل شركة بعض الأجهزة لديها قيمة مثلما عندما
+
+981
+01:06:00,700 --> 01:06:07,660
+تشتري حاجز ماهي أفضل شركة لحاجز؟باج .. handbags
+
+982
+01:06:07,660 --> 01:06:13,060
+handbags what the best .. what the best brand؟
+
+983
+01:06:13,060 --> 01:06:18,240
+well there are some .. some brand .. like watch ..
+
+984
+01:06:18,240 --> 01:06:20,700
+when you buy a watch you have some brands like
+
+985
+01:06:20,700 --> 01:06:26,100
+Rolex, bags like Gucci, glasses .. those have
+
+986
+01:06:26,100 --> 01:06:31,020
+brand when you buy you expect a high quality and
+
+987
+01:06:31,020 --> 01:06:33,660
+you pay .. like some bag .. handbags cost one
+
+988
+01:06:33,660 --> 01:06:40,290
+thousand dollarوالشيء الوحيد هو أنك تستطيع أن تدفع
+
+989
+01:06:40,290 --> 01:06:47,730
+10 دولار لجمهورك و تدفع 10 دولار لجمهورك و تدفع 10
+
+990
+01:06:47,730 --> 01:06:48,170
+دولار لجمهورك و تدفع 10 دولار لجمهورك و تدفع 10
+
+991
+01:06:48,170 --> 01:06:48,310
+دولار لجمهورك و تدفع 10 دولار لجمهورك و تدفع 10
+
+992
+01:06:48,310 --> 01:06:48,570
+دولار لجمهورك و تدفع 10 دولار لجمهورك و تدفع 10
+
+993
+01:06:48,570 --> 01:06:48,570
+دولار لجمهورك و تدفع 10 دولار لجمهورك و تدفع 10
+
+994
+01:06:48,570 --> 01:06:50,070
+دولار لجمهورك و تدفع 10 دولار لجمهورك و تدفع 10
+
+995
+01:06:50,070 --> 01:06:52,160
+دولار لجمهورك و تدفع 10 دولار لجمهsome people pay
+
+996
+01:06:52,160 --> 01:06:55,060
+for the name but even even if it's a name brand
+
+997
+01:06:55,060 --> 01:06:57,720
+name but most likely you can imagine this brand
+
+998
+01:06:57,720 --> 01:07:01,040
+name based on the quality otherwise if if there is
+
+999
+01:07:01,040 --> 01:07:04,340
+no good quality it will not get to that high class
+
+1000
+01:07:04,340 --> 01:07:07,500
+here brand it's high expectation i think it's
+
+1001
+01:07:07,500 --> 01:07:11,900
+enough for today thank you for your time i'm
+
+1002
+01:07:11,900 --> 01:07:13,340
+seeing you i'm gonna see you tuesday
+
diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/PrJKYgIaT2o_raw.json b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/PrJKYgIaT2o_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..737633ab595e0e74bffa42692893fc54cb8fa413
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/PrJKYgIaT2o_raw.json
@@ -0,0 +1 @@
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{"start": 3218.45, "end": 3218.85, "word": " new,", "probability": 0.701171875}, {"start": 3219.01, "end": 3219.15, "word": " well", "probability": 0.433837890625}, {"start": 3219.15, "end": 3219.35, "word": " look", "probability": 0.94287109375}, {"start": 3219.35, "end": 3219.53, "word": " what", "probability": 0.90966796875}, {"start": 3219.53, "end": 3219.67, "word": " we", "probability": 0.90234375}, {"start": 3219.67, "end": 3219.79, "word": " gonna", "probability": 0.33837890625}, {"start": 3219.79, "end": 3219.93, "word": " do", "probability": 0.96728515625}, {"start": 3219.93, "end": 3220.13, "word": " next", "probability": 0.93115234375}, {"start": 3220.13, "end": 3220.47, "word": " time", "probability": 0.88623046875}, {"start": 3220.47, "end": 3221.41, "word": " anyway", "probability": 0.59765625}, {"start": 3221.41, "end": 3223.17, "word": " we", "probability": 0.53564453125}, {"start": 3223.17, "end": 3223.37, "word": " look", "probability": 0.95263671875}, {"start": 3223.37, "end": 3223.51, "word": " at", "probability": 0.96630859375}, {"start": 3223.51, "end": 3223.73, "word": " the", "probability": 0.8857421875}, {"start": 3223.73, "end": 3224.35, "word": " agency", "probability": 0.9140625}, {"start": 3224.35, "end": 3224.79, "word": " duties,", "probability": 0.96826171875}, {"start": 3225.09, "end": 3225.29, "word": " do", "probability": 0.72021484375}, {"start": 3225.29, "end": 3225.35, "word": " you", "probability": 0.96728515625}, {"start": 3225.35, "end": 3225.51, "word": " want", "probability": 0.88916015625}, {"start": 3225.51, "end": 3225.63, "word": " me", "probability": 0.95751953125}, {"start": 3225.63, "end": 3225.75, "word": " to", "probability": 0.974609375}, {"start": 3225.75, "end": 3225.87, "word": " leave", "probability": 0.96533203125}, {"start": 3225.87, "end": 3225.95, "word": " it", "probability": 0.83544921875}, {"start": 3225.95, "end": 3226.07, "word": " for", "probability": 0.95166015625}, {"start": 3226.07, "end": 3226.25, "word": " next", "probability": 0.87060546875}, {"start": 3226.25, "end": 3226.55, "word": " time?", "probability": 0.8798828125}, {"start": 3228.21, "end": 3228.43, "word": " leave", "probability": 0.734375}, {"start": 3228.43, "end": 3228.53, "word": " it", "probability": 0.890625}, {"start": 3228.53, "end": 3228.63, "word": " for", "probability": 0.96435546875}, {"start": 3228.63, "end": 3228.81, "word": " next", "probability": 0.92041015625}, {"start": 3228.81, "end": 3229.13, "word": " time?", "probability": 0.8857421875}, {"start": 3230.21, "end": 3230.61, "word": " what", "probability": 0.59814453125}, {"start": 3230.61, "end": 3230.71, "word": " do", "probability": 0.90625}, {"start": 3230.71, "end": 3230.71, "word": " you", "probability": 0.9736328125}, {"start": 3230.71, "end": 3230.93, "word": " think?", "probability": 0.92529296875}], "temperature": 1.0}, {"id": 126, "seek": 325631, "start": 3233.25, "end": 3256.31, "text": "we still have time okay we're gonna we're gonna stop here and we're gonna have discussion now listen look at me we will stop here we're gonna take discussions for eight seven minutes discussion about the subject evaluation and next time when we come we have to complete or we have to complete by looking at agents duties okay thanks for your time", "tokens": [826, 920, 362, 565, 1392, 321, 434, 799, 321, 434, 799, 1590, 510, 293, 321, 434, 799, 362, 5017, 586, 2140, 574, 412, 385, 321, 486, 1590, 510, 321, 434, 799, 747, 11088, 337, 3180, 3407, 2077, 5017, 466, 264, 3983, 13344, 293, 958, 565, 562, 321, 808, 321, 362, 281, 3566, 420, 321, 362, 281, 3566, 538, 1237, 412, 12554, 20910, 1392, 3231, 337, 428, 565], "avg_logprob": -0.22794117712799242, "compression_ratio": 1.8907103825136613, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 3233.25, "end": 3233.43, "word": "we", "probability": 0.1295166015625}, {"start": 3233.43, "end": 3233.63, "word": " still", "probability": 0.77587890625}, {"start": 3233.63, "end": 3233.83, "word": " have", "probability": 0.94873046875}, {"start": 3233.83, "end": 3234.11, "word": " time", "probability": 0.8916015625}, {"start": 3234.11, "end": 3234.55, "word": " okay", "probability": 0.56298828125}, {"start": 3234.55, "end": 3235.35, "word": " we're", "probability": 0.621337890625}, {"start": 3235.35, "end": 3235.47, "word": " gonna", "probability": 0.82177734375}, {"start": 3235.47, "end": 3235.73, "word": " we're", "probability": 0.714111328125}, {"start": 3235.73, "end": 3235.81, "word": " gonna", "probability": 0.8583984375}, {"start": 3235.81, "end": 3236.17, "word": " stop", "probability": 0.94970703125}, {"start": 3236.17, "end": 3236.51, "word": " here", "probability": 0.8603515625}, {"start": 3236.51, "end": 3237.09, "word": " and", "probability": 0.7900390625}, {"start": 3237.09, "end": 3237.29, "word": " we're", "probability": 0.560791015625}, {"start": 3237.29, "end": 3237.41, "word": " gonna", "probability": 0.77001953125}, {"start": 3237.41, "end": 3237.61, "word": " have", "probability": 0.94970703125}, {"start": 3237.61, "end": 3238.07, "word": " discussion", "probability": 0.8115234375}, {"start": 3238.07, "end": 3238.39, "word": " now", "probability": 0.95361328125}, {"start": 3238.39, "end": 3239.05, "word": " listen", "probability": 0.94189453125}, {"start": 3239.05, "end": 3239.27, "word": " look", "probability": 0.9775390625}, {"start": 3239.27, "end": 3239.41, "word": " at", "probability": 0.98095703125}, {"start": 3239.41, "end": 3239.63, "word": " me", "probability": 0.97802734375}, {"start": 3239.63, "end": 3240.25, "word": " we", "probability": 0.92724609375}, {"start": 3240.25, "end": 3240.37, "word": " will", "probability": 0.34619140625}, {"start": 3240.37, "end": 3240.65, "word": " stop", "probability": 0.947265625}, {"start": 3240.65, "end": 3240.95, "word": " here", "probability": 0.859375}, {"start": 3240.95, "end": 3241.67, "word": " we're", "probability": 0.802734375}, {"start": 3241.67, "end": 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/PrJKYgIaT2o_raw.srt b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/PrJKYgIaT2o_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..86403b0fe61cde3cd3a5d1f21ee8408f29cb5d72
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/PrJKYgIaT2o_raw.srt
@@ -0,0 +1,2860 @@
+1
+00:00:12,840 --> 00:00:18,090
+العربيةOkay بسم الله الرحمن الرحيم again for the
+
+2
+00:00:18,090 --> 00:00:22,450
+second time what we had last lecture was agency
+
+3
+00:00:22,450 --> 00:00:26,390
+today is the second lecture of agency in which we
+
+4
+00:00:26,390 --> 00:00:29,850
+have to look at the authority of the agent and how
+
+5
+00:00:29,850 --> 00:00:32,310
+much power the agent can have to be able to act
+
+6
+00:00:32,310 --> 00:00:36,230
+last time we had the conception the definition
+
+7
+00:00:37,410 --> 00:00:43,170
+الأسلحة والمشاركة وكان لدينا معنى للمشاركة التي هي
+
+8
+00:00:43,170 --> 00:00:47,550
+مجموعة من علاقات ثلاث مجموعات كما ترى هنا هذا
+
+9
+00:00:47,550 --> 00:00:52,810
+النوع من العلاقات نجد أن المشاركة هي شخص يمكن أن
+
+10
+00:00:52,810 --> 00:00:58,070
+يسمح للمشاركة أن تعمل على حسابه والمشاركة هي شخص
+
+11
+00:00:58,070 --> 00:01:03,750
+يعمل على حساب المشاركة لتعمل على حساب المشاركة
+
+12
+00:01:03,750 --> 00:01:05,940
+لتعمل على حساب المشاركة لتعمل على حساب المشاركةو
+
+13
+00:01:05,940 --> 00:01:09,220
+يجب أن ننظر إلى المساعدة، من سيكون مساعدًا في أخير
+
+14
+00:01:09,220 --> 00:01:13,540
+المسؤلية القانونية، فالأمر يعتمد على الرقم لأن
+
+15
+00:01:13,540 --> 00:01:20,040
+الرقم لديه المال والقوة والقوة والسلطة وهو مؤسسة
+
+16
+00:01:20,040 --> 00:01:24,480
+الشركة وانه أو انها ستحصل على هذا القوة ويمكن أن
+
+17
+00:01:24,480 --> 00:01:30,870
+تتم تحريرها منه إلى مؤسسةهذه الحكومة كما ترى هنا
+
+18
+00:01:30,870 --> 00:01:35,910
+هي شيء من قوة يمكن أن تتحرك من شخصية لشخصية أخرى
+
+19
+00:01:35,910 --> 00:01:42,190
+في .. في حالة عادية يمكن أن يكون شخص ما يفعل في
+
+20
+00:01:42,190 --> 00:01:46,690
+اسمه كشركة أو كشركة يستطيع أن يفعل .. يمكنك أن
+
+21
+00:01:46,690 --> 00:01:51,870
+تسعى يمكنك أن تشتريبعض الأحيان في بعض الحالات في
+
+22
+00:01:51,870 --> 00:01:55,910
+مؤسسة هذا الشخص الرئيسي اللي لم يكن قادر على
+
+23
+00:01:55,910 --> 00:01:58,970
+التعامل الرئيسي لم يكن لديه وقت لا يمكن الرئيس أن
+
+24
+00:01:58,970 --> 00:02:03,370
+يكون شخص مخاطر الرئيس سيحتاج إلى شخص أخر يتعامل
+
+25
+00:02:03,370 --> 00:02:06,630
+على جانبه اللي يسمى مجرد مجرد مجرد مجرد مجرد مجرد
+
+26
+00:02:06,630 --> 00:02:07,030
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+27
+00:02:07,030 --> 00:02:11,470
+مجرد مجرد مجرد مجرد
+
+28
+00:02:21,290 --> 00:02:24,270
+السؤال اللي طلعنا نطلعه مرة أخرى و سنطلعه مرة أخرى
+
+29
+00:02:24,270 --> 00:02:33,010
+اليوم هو كم قوة و كم حكم يمكن أن يكون للموظف نحن
+
+30
+00:02:33,010 --> 00:02:36,410
+لدينا ثلاث أسلوب اذا كنت أستطيع أن أعطي شخص ما أن
+
+31
+00:02:36,410 --> 00:02:42,980
+يفعل كل شيء في حياتيلديك اشخاص مختلفين يعملون
+
+32
+00:02:42,980 --> 00:02:46,920
+بطريقات مختلفة، يكون لديهم قوة ممكن تكون في بعض
+
+33
+00:02:46,920 --> 00:02:54,020
+الأحيان مثل قوة المسؤولين ولكن هذا ليس في كل
+
+34
+00:02:54,020 --> 00:02:58,780
+الحالات، لدينا ثلاثة أشخاص مستخدمين مستخدمين
+
+35
+00:02:58,780 --> 00:03:03,500
+مستخدمين عاملين ومستخدمين
+
+36
+00:03:03,500 --> 00:03:11,330
+مستخدمين خاصةفي نفس الوقت، كمية حكومة يمتلك
+
+37
+00:03:11,330 --> 00:03:17,610
+الشركة؟ نقول أنه يتعامل معها و كيف يتم تحويل هذه
+
+38
+00:03:17,610 --> 00:03:22,270
+الحكومة؟ بكلمات، بإدارة، بشكل مبالغ أو مبالغ؟
+
+39
+00:03:22,270 --> 00:03:25,710
+مثلًا، إذا كنت أرغب في إعطاء شخص ما أن يكون شركتي،
+
+40
+00:03:25,710 --> 00:03:30,840
+فأنا أستطيع إعطاء ذلك الشخص بشكل مبالغit's clear
+
+41
+00:03:30,840 --> 00:03:34,520
+not disputed I can say well that person is my
+
+42
+00:03:34,520 --> 00:03:38,060
+agent and that's it it's clear you can understand
+
+43
+00:03:38,060 --> 00:03:41,220
+from my words you can understand from my conduct
+
+44
+00:03:41,220 --> 00:03:46,540
+it can be explicit authorization it can be
+
+45
+00:03:46,540 --> 00:03:51,710
+explicitly clearundisputed sometimes it can be
+
+46
+00:03:51,710 --> 00:03:56,730
+implicit or implied authority implied by
+
+47
+00:03:56,730 --> 00:04:00,010
+impression I make the impression انطباع that
+
+48
+00:04:00,010 --> 00:04:04,170
+someone is my agent and I did not say that I did
+
+49
+00:04:04,170 --> 00:04:08,890
+not even make any conductعن طريق اعمال صحيحة لكي
+
+50
+00:04:08,890 --> 00:04:13,210
+اثبت ان انا اعطى تلك الاختصار تلك القوة لشخص اخر
+
+51
+00:04:13,210 --> 00:04:21,910
+لكي تفهم من حركتي تفهم بشكل مبالغي ان الشخص اللي
+
+52
+00:04:21,910 --> 00:04:30,750
+يعمل على جانبي اول مرة نسميها قوة حقيقية قوة
+
+53
+00:04:30,750 --> 00:04:33,630
+حقيقية هذه القوة من الرئيس للمشخص
+
+54
+00:04:35,720 --> 00:04:40,140
+number one is actual it's a factual it's a reality
+
+55
+00:04:40,140 --> 00:04:44,400
+it's clear it's not disputed we can see we can
+
+56
+00:04:44,400 --> 00:04:48,460
+notice like saying to somebody well arwa is my
+
+57
+00:04:48,460 --> 00:04:54,590
+agentفي هذه الحالة فانت تفهم أنها مصطلحتي و ليست
+
+58
+00:04:54,590 --> 00:04:58,050
+مقارنة بكتير بكتير بكتير بكتير بكتير بكتير بكتير
+
+59
+00:04:58,050 --> 00:04:58,290
+بكتير بكتير بكتير بكتير بكتير بكتير بكتير بكتير
+
+60
+00:04:58,290 --> 00:05:00,290
+بكتير بكتير بكتير بكتير بكتير بكتير بكتير بكتير
+
+61
+00:05:00,290 --> 00:05:00,770
+بكتير بكتير بكتير بكتير بكتير بكتير بكتير بكتير
+
+62
+00:05:00,770 --> 00:05:02,830
+بكتير بكتير بكتير بكتير بكتير بكتير بكتير بكتير
+
+63
+00:05:02,830 --> 00:05:06,870
+بكتير بكتير بكتير بكتير بكتير بكتير بكتير بكتير
+
+64
+00:05:06,870 --> 00:05:12,590
+بكتير بكتير ب
+
+65
+00:05:14,920 --> 00:05:17,660
+وانت تريد أن تشتريها اعطيك الكمبيوتر وانت تعطيني
+
+66
+00:05:17,660 --> 00:05:22,620
+المال وانت لديك الهدف هذا هو اتفاق ليس كل شيء يجب
+
+67
+00:05:22,620 --> 00:05:27,100
+ان يكون مكتوب في الاسم لا لذلك الاسم اللي قلناه
+
+68
+00:05:27,100 --> 00:05:31,060
+الماضي هو الاصطناع الواقعي هو الاصطناع الواضح يمكن
+
+69
+00:05:31,060 --> 00:05:32,720
+أن يكون من ناحية التدريب في بعض الوقت من ناحية
+
+70
+00:05:32,720 --> 00:05:36,160
+التدريب يمكن أن يكون من ناحية المشاركة ولكن نستطيع
+
+71
+00:05:36,160 --> 00:05:43,320
+أن نفهم أن هناك شخص يعمل كمشاركة لشخص أخرفي حالة
+
+72
+00:05:43,320 --> 00:05:50,800
+كذلك، المسؤولية ستكون على أسلوب المصطلح اليوم
+
+73
+00:05:50,800 --> 00:05:54,760
+سننظر إلى الطريقة الثانية .. الطريقة الثانية
+
+74
+00:05:54,760 --> 00:06:00,180
+للوطنية التي تسمى بـ Apparent أو وطنية وطنية وطنية
+
+75
+00:06:00,180 --> 00:06:02,660
+وطنية وطنية وطنية وطنية وطنية وطنية وطنية وطنية
+
+76
+00:06:02,660 --> 00:06:04,920
+وطنية وطنية وطنية وطنية وطنية وطنية وطنية وطنية
+
+77
+00:06:04,920 --> 00:06:05,100
+وطنية وطنية وطنية وطنية وطنية وطنية وطنية وطنية
+
+78
+00:06:05,100 --> 00:06:05,360
+وطنية وطنية وطنية وطنية وطنية وطنية وطنية وطنية
+
+79
+00:06:05,360 --> 00:06:09,610
+وطنية وطنية وطنية وطنية وطنية وit looks to me and
+
+80
+00:06:09,610 --> 00:06:12,770
+it looks to you that we have an authority we have
+
+81
+00:06:12,770 --> 00:06:16,190
+a power i can act but in fact there is no agency
+
+82
+00:06:16,190 --> 00:06:20,170
+in fact there is no agency like by this you can
+
+83
+00:06:20,170 --> 00:06:23,670
+see here that the principles words or conducts you
+
+84
+00:06:23,670 --> 00:06:25,810
+can understand from the words from the conduct
+
+85
+00:06:25,810 --> 00:06:30,970
+these words my words my conduct would lead a
+
+86
+00:06:30,970 --> 00:06:34,430
+reasonable person someone reasonable person شخص
+
+87
+00:06:34,430 --> 00:06:39,370
+معقول in the marketالشخص هو أو هي في موقع ثالث
+
+88
+00:06:39,370 --> 00:06:44,950
+الشركات لتؤمن بأنني كنت مستخدم أو أن الشخص كنت
+
+89
+00:06:44,950 --> 00:06:52,290
+مستخدم، إنه شخص في المجتمع، شخص في السوقيمكنك أن
+
+90
+00:06:52,290 --> 00:06:57,330
+تنظر إلى الموضوع و تقرأ الموضوع و تفهم أننا لدينا
+
+91
+00:06:57,330 --> 00:07:03,450
+قوة ولكن هذه القوة لا تأتي من المجلس ليس من المجلس
+
+92
+00:07:03,450 --> 00:07:09,510
+الحقيقي ليس من القوة الحقيقية ولكن في الحقيقة هناك
+
+93
+00:07:09,510 --> 00:07:16,550
+قوة وهذه القوة تأتي من موقع مثل هنا رقم واحد و رقم
+
+94
+00:07:16,550 --> 00:07:22,170
+اثنان لدينا اثنان مواقع انظر إلى رقم واحدit's by
+
+95
+00:07:22,170 --> 00:07:28,710
+appointment by appointing somebody appointing the
+
+96
+00:07:28,710 --> 00:07:32,390
+agent to a position I would like to read it
+
+97
+00:07:32,390 --> 00:07:48,130
+someone can read it from me okay
+
+98
+00:07:48,130 --> 00:07:53,140
+good if you look here againفي هذه الحالة في هذه
+
+99
+00:07:53,140 --> 00:07:54,680
+الحالة لدينا اكتشاف اكتشاف اكتشاف اكتشاف اكتشاف
+
+100
+00:07:54,680 --> 00:07:56,060
+اكتشاف اكتشاف اكتشاف اكتشاف اكتشاف اكتشاف اكتشاف
+
+101
+00:07:56,060 --> 00:07:57,360
+اكتشاف اكتشف اكتشف اكتشف اكتشف اكتشف اكتشف اكتشف
+
+102
+00:07:57,360 --> 00:07:59,360
+اكتشف اكتشف اكتشف اكتشف اكتشف اكتشف اكتشف اكتشف
+
+103
+00:07:59,360 --> 00:08:01,320
+اكتشف اكتشف اكتشف اكتشف اكتشف اكتشف اكتشف اكتشف
+
+104
+00:08:01,320 --> 00:08:05,340
+اكتشف اكتشف
+
+105
+00:08:05,340 --> 00:08:14,460
+اكتشف اكتشف اكتشف اكتشف ا
+
+106
+00:08:19,680 --> 00:08:25,300
+لو يبدو انه مجلس و ليس مجلس احد لديه قوة مثلا انا
+
+107
+00:08:25,300 --> 00:08:30,000
+اعطيك مثال بسيط مثلا لدينا جوال company انها شركة
+
+108
+00:08:30,000 --> 00:08:35,140
+تلكوميكية عندما تذهب تشتري هاتف موبايل عندما تذهب
+
+109
+00:08:35,140 --> 00:08:41,740
+تشتري شركة لتكون لديها شرط للمواصلة من شركة جوال
+
+110
+00:08:41,740 --> 00:08:46,500
+monthly payments انت تشتري الشركة مع السيدة خلف ال
+
+111
+00:08:48,460 --> 00:08:52,380
+that lady or that man are not agents they are not
+
+112
+00:08:52,380 --> 00:08:57,040
+they are working for جوال company members of staff
+
+113
+00:08:57,040 --> 00:09:01,680
+employees so in this situation here those people
+
+114
+00:09:01,680 --> 00:09:04,920
+who are working for جوال company or for bank of
+
+115
+00:09:04,920 --> 00:09:08,920
+palestine they are members of staff they are not
+
+116
+00:09:08,920 --> 00:09:12,700
+agents but the thing is that those people having
+
+117
+00:09:12,700 --> 00:09:19,520
+what agency like power what does it mean to youهل
+
+118
+00:09:19,520 --> 00:09:24,300
+لديهم القوة؟ نعم هم يستطيعوا أن يعملوا، يستطيعوا
+
+119
+00:09:24,300 --> 00:09:27,000
+أن تشتركوا، يستطيعوا أن تسحبوا شيء منك، يستطيعوا
+
+120
+00:09:27,000 --> 00:09:30,680
+أن تحصلوا على المال منك، لكنهم ليسوا مجلسين، هم
+
+121
+00:09:30,680 --> 00:09:36,740
+موظفين، لكنهم لديهم القوة والعثورية مثل القوة
+
+122
+00:09:36,740 --> 00:09:41,340
+والعثورية من مجلس مجلس مجلس مجلس مجلس مجلس مجلس
+
+123
+00:09:41,340 --> 00:09:42,100
+مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس
+
+124
+00:09:42,100 --> 00:09:44,160
+مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس
+
+125
+00:09:44,160 --> 00:09:46,680
+مجلس م
+
+126
+00:09:49,590 --> 00:09:56,890
+الشخص ليس عميلًا ولكنه أو هي تعمل كشخص من الوظيفة،
+
+127
+00:09:56,890 --> 00:10:03,650
+هذا الشخص يمكن أن يتعامل على حساب الرئيس، على حساب
+
+128
+00:10:03,650 --> 00:10:07,870
+الشركة، ولكنه ليس يتعامل كعمل عميل، إنه يتعامل
+
+129
+00:10:07,870 --> 00:10:12,890
+كشخص من الوظيفة، في هذه الحالة، هو أو هي سيكون
+
+130
+00:10:12,890 --> 00:10:18,200
+لديها حكمةمن الشركة هذه الحكومة مثل حكومة شركة
+
+131
+00:10:18,200 --> 00:10:18,540
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+132
+00:10:18,540 --> 00:10:25,960
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+133
+00:10:25,960 --> 00:10:31,460
+شركة شركة شركة شركة شركة شركة شركة anyone here
+
+134
+00:11:03,370 --> 00:11:10,200
+Okay so anyone in this situation any customerالشخص
+
+135
+00:11:10,200 --> 00:11:14,100
+اللي يرى هذه الحالة يستطيع أن يعتمد أن هذا الشخص
+
+136
+00:11:14,100 --> 00:11:17,360
+يعمل على مجلد الشركة وإذا كنت تذهب إلى شركة جوال
+
+137
+00:11:17,360 --> 00:11:21,300
+لتشتري هاتف موبايل تستطيع أن تعتمد أن تلك السيدة
+
+138
+00:11:21,300 --> 00:11:23,460
+أو ذلك الرجل اللي يقعد خلف الكمبيوتر و يقعد خلف
+
+139
+00:11:23,460 --> 00:11:28,900
+الكمبيوتر و يتعامل معك تلك الشخص يعمل لماذا؟ لشركة
+
+140
+00:11:28,900 --> 00:11:32,780
+جوال و هو أو هي ستكون لديها حكومة تستطيع أن تتعامل
+
+141
+00:11:32,780 --> 00:11:35,280
+مع المستخدم و تستطيع أن تعتمد أنك تستطيع أن تعتمد
+
+142
+00:11:35,280 --> 00:11:43,570
+على ذلك تعتمد أن هو ..you know assume يفترض if you
+
+143
+00:11:43,570 --> 00:11:45,950
+have any word you find it difficult and you cannot
+
+144
+00:11:45,950 --> 00:11:49,690
+understand it please let me know even if it's
+
+145
+00:11:49,690 --> 00:11:51,510
+recorded that's fine i'm gonna translate it for
+
+146
+00:11:51,510 --> 00:11:54,150
+you any word you find it difficult i will
+
+147
+00:11:54,150 --> 00:11:56,390
+translate it how do you find it up to now is it
+
+148
+00:11:56,390 --> 00:12:05,030
+okay straightforward easy good second second type
+
+149
+00:12:05,030 --> 00:12:10,970
+which isأنه يكون لدينا اكتران اكتران اكتران اكتران
+
+150
+00:12:10,970 --> 00:12:12,950
+اكتران اكتران اكتران اكتران اكتران اكتران اكتران
+
+151
+00:12:12,950 --> 00:12:16,390
+اكتران اكتران اكتران اكتران اكتران اكتران اكتران
+
+152
+00:12:16,390 --> 00:12:22,030
+اكتران اكتران اكتران اكتران اكتران اكتران اكتران
+
+153
+00:12:22,030 --> 00:12:22,650
+اكتران اكتران اكتران اكتران اكتران اكتران اكتران
+
+154
+00:12:22,650 --> 00:12:22,690
+اكتران اكتران اكتران اكتران اكتران اكتران اكتران
+
+155
+00:12:22,690 --> 00:12:32,510
+اكتران اكتران اكتران اكتران ا
+
+156
+00:12:32,640 --> 00:12:36,260
+authority it's an authority which can be given to
+
+157
+00:12:36,260 --> 00:12:40,780
+the agent by impression by implying implying
+
+158
+00:12:40,780 --> 00:12:45,640
+what's your name what
+
+159
+00:12:45,640 --> 00:12:53,520
+does it mean okay
+
+160
+00:12:53,520 --> 00:13:01,510
+good now i forgot what i'm gonna sayانا اقول ان
+
+161
+00:13:01,510 --> 00:13:07,050
+اذا كنت اقول ان عنود هي مصطلحي، وان انا لم اقول اي
+
+162
+00:13:07,050 --> 00:13:13,550
+احد، وانا لم اخبرك ببساطة ببساطة ببساطة ببساطة
+
+163
+00:13:13,550 --> 00:13:13,550
+ببساطة ببساطة ببساطة ببساطة ببساطة ببساطة ببساطة
+
+164
+00:13:13,550 --> 00:13:13,550
+ببساطة ببساطة ببساطة ببساطة ببساطة ببساطة ببساطة
+
+165
+00:13:13,550 --> 00:13:16,330
+ببساطة ببساطة ببساطة ببساطة ببساطة ببساطة ببساطة
+
+166
+00:13:16,330 --> 00:13:16,870
+ببساطة ببساطة ببساطة ببساطة ببساطة ببساطة ببساطة
+
+167
+00:13:16,870 --> 00:13:26,290
+ببساطة ببساطة ببساطة ببساطة
+
+168
+00:13:26,290 --> 00:13:33,800
+ببفي هذه الحالة هي .. فلما تفهم هذا و القواعد ..
+
+169
+00:13:33,800 --> 00:13:39,780
+القواعد ستحميك كشباب .. كشباب ثالث .. يجب أن نبحث
+
+170
+00:13:39,780 --> 00:13:46,060
+عنك كشباب .. ليس الرئيس .. ليس الوظيفة .. أول مهمة
+
+171
+00:13:46,060 --> 00:13:51,680
+هي الشباب .. هم سيأتيون أول .. فلما يكونوا عذرين
+
+172
+00:13:51,680 --> 00:13:57,410
+.. صادرين ..this situation even though in fact
+
+173
+00:13:57,410 --> 00:14:02,950
+there is no authority no agency in fact but by
+
+174
+00:14:02,950 --> 00:14:09,230
+implicit by implying ضمنا أو حتا لكم بالإحاد by
+
+175
+00:14:09,230 --> 00:14:12,570
+any activity that you believe that she is my agent
+
+176
+00:14:12,570 --> 00:14:15,570
+then in this case you can deal with her and then I
+
+177
+00:14:15,570 --> 00:14:18,530
+will be responsible as a principal I can be
+
+178
+00:14:18,530 --> 00:14:20,590
+responsible in this case I will have to compensate
+
+179
+00:14:20,590 --> 00:14:24,210
+you I will be liable for any lossبقى in this
+
+180
+00:14:24,210 --> 00:14:28,010
+situation we have no agency between me and our
+
+181
+00:14:28,010 --> 00:14:32,850
+principal and agent there is no actual agency what
+
+182
+00:14:32,850 --> 00:14:37,490
+can we do؟ now if one of you as a third part of a
+
+183
+00:14:37,490 --> 00:14:42,370
+customer have dealt with an agent and this agent
+
+184
+00:14:42,370 --> 00:14:45,230
+is not a real agent is not an actual authority we
+
+185
+00:14:45,230 --> 00:14:49,150
+do not have an actual authority then will I be
+
+186
+00:14:49,150 --> 00:14:52,580
+liable here or not؟yes because I gave the
+
+187
+00:14:52,580 --> 00:14:55,280
+impression it's my .. it's my mistake it's my
+
+188
+00:14:55,280 --> 00:14:59,100
+authority I authorizes it أنا قضيت الموافقة
+
+189
+00:14:59,100 --> 00:15:02,580
+already I have given that even if it's by implying
+
+190
+00:15:02,580 --> 00:15:05,440
+it like but in this situation we find it's a
+
+191
+00:15:05,440 --> 00:15:08,040
+little bit difficult to explain this point there
+
+192
+00:15:08,040 --> 00:15:10,580
+is something called in this case in this situation
+
+193
+00:15:10,580 --> 00:15:16,840
+agency by stopple if stopple even if you look at
+
+194
+00:15:16,840 --> 00:15:19,100
+the dictionary English dictionary you will not
+
+195
+00:15:19,100 --> 00:15:23,960
+gonna find itdelocator agency by stoppel stoppel
+
+196
+00:15:23,960 --> 00:15:27,320
+it's kind of a de facto situation de facto legal
+
+197
+00:15:27,320 --> 00:15:31,480
+situation in
+
+198
+00:15:31,480 --> 00:15:34,840
+which that we have to assume there is an agency
+
+199
+00:15:34,840 --> 00:15:40,500
+يعني نفترض there is an agency but there is no
+
+200
+00:15:40,500 --> 00:15:44,200
+agency in fact here in this case I did not
+
+201
+00:15:44,200 --> 00:15:50,550
+authorize my agent to act clearlyولكنك كمستخدم
+
+202
+00:15:50,550 --> 00:15:56,410
+فانت فهمت مني أنه او انها مصطلحي او مصطلح او مصطلح
+
+203
+00:15:56,410 --> 00:15:56,530
+او مصطلح او مصطلح او مصطلح او مصطلح او مصطلح او
+
+204
+00:15:56,530 --> 00:15:58,710
+مصطلح او مصطلح او مصطلح او مصطلح او مصطلح او مصطلح
+
+205
+00:15:58,710 --> 00:16:00,830
+او مصطلح او مصطلح او مصطلح او مصطلح او مصطلح او
+
+206
+00:16:00,830 --> 00:16:00,830
+مصطلح او مصطلح او مصطلح او مصطلح او مصطلح او مصطلح
+
+207
+00:16:00,830 --> 00:16:10,550
+او مصطلح او مصطلح او مصطلح او مصطلح
+
+208
+00:16:15,360 --> 00:16:20,080
+الأسلحة ستكون مقابلة ومسؤولة بطريقة عامة ستكون
+
+209
+00:16:20,080 --> 00:16:24,240
+عليها أن تدفع ، ستذهب إلى كومبنزين لماذا؟ لأننا
+
+210
+00:16:24,240 --> 00:16:29,480
+لدينا شيء يسمى agency by stabilة نحن نعتقد أنه إذا
+
+211
+00:16:29,480 --> 00:16:32,480
+كان هناك agency لكن في الحقيقة لا ، لم يكن هناك
+
+212
+00:16:32,480 --> 00:16:37,080
+agency هذا مضمون على ماذا؟ مضمون على نقطة واحدة
+
+213
+00:16:37,080 --> 00:16:43,060
+هنا المضمونة هي إنك تشوف معي أن الأسلحة لا يمكن أن
+
+214
+00:16:43,060 --> 00:16:48,370
+تدفعالرئيس لا يمكن أن يتخلص من اعطاء القوية إذا
+
+215
+00:16:48,370 --> 00:16:54,110
+تغيرت ثالث الحكومات موقعها
+
+216
+00:16:54,110 --> 00:17:01,150
+في التعامل مع مجموعة الوظيفة هذه الثالثة الحكومات
+
+217
+00:17:01,150 --> 00:17:09,030
+تغيرت موقعها بما يتعامل مع هذه الحالة بإيمان أن
+
+218
+00:17:09,030 --> 00:17:15,270
+كان هناك مؤسسة هذه الثالثة الحكومات صنعت المالوهو
+
+219
+00:17:15,270 --> 00:17:21,770
+كان يؤمن بأن هناك مجلس لكن في الحقيقة لا يوجد مجلس
+
+220
+00:17:21,770 --> 00:17:25,970
+وكان يغيّر حالته لم يرغب في اشتري من ذلك المكان،
+
+221
+00:17:25,970 --> 00:17:31,150
+اشتري مننا اشتري المال وقام بتعامل مع شركتنا، يؤمن
+
+222
+00:17:31,150 --> 00:17:35,610
+بأن كل شيء بخير ومقالي ونحن لدينا مجلس، وقام
+
+223
+00:17:35,610 --> 00:17:41,330
+بتغيير من شركة A لشركة B يتعامل معنا، فقام بتغيير
+
+224
+00:17:41,330 --> 00:17:42,090
+موقعه
+
+225
+00:17:44,690 --> 00:17:48,850
+عن ما يؤمن بأننا لدينا مؤسسة في هذه الحالة يجب أن
+
+226
+00:17:48,850 --> 00:17:55,190
+نبحث عن هذا المستخدم يجب أن لا نفرض حقه يجب أن
+
+227
+00:17:55,190 --> 00:18:01,230
+نعطيه أحد ممكن يسألني كدراسة سيسألني ماذا تعني بـ
+
+228
+00:18:01,230 --> 00:18:08,050
+liability هنا؟ إذا كانت التعامل مع .. إذا كانت
+
+229
+00:18:08,050 --> 00:18:13,480
+التعامل مع مؤسسةوالشخص الذي يعمل التعامل كان مجرد
+
+230
+00:18:13,480 --> 00:18:16,960
+عملية التعامل بالفعل كيف يمكن أن يكون الرئيس مخطط؟
+
+231
+00:18:16,960 --> 00:18:23,420
+مثلًا إذا كان شخصًا يعمل مني كمشغل أنا كنت الرئيس
+
+232
+00:18:23,420 --> 00:18:29,180
+ولكن هذا الشخص لم يعمل مني بعد الآن، لقد رحل، فهو
+
+233
+00:18:29,180 --> 00:18:35,640
+ذهب إلى شركة أخر لعمل منهاالوظيفة السابقة ليست
+
+234
+00:18:35,640 --> 00:18:39,540
+معملة لدي بعد ذلك، واحد من المستخدمين اللي كان
+
+235
+00:18:39,540 --> 00:18:43,220
+يتعامل مع مستخدمي كنيسة كنيسة كنيسة كنيسة كنيسة
+
+236
+00:18:43,220 --> 00:18:43,740
+كنيسة كنيسة كنيسة كنيسة كنيسة كنيسة كنيسة كنيسة
+
+237
+00:18:43,740 --> 00:18:43,780
+كنيسة كنيسة كنيسة كنيسة كنيسة كنيسة كنيسة كنيسة
+
+238
+00:18:43,780 --> 00:18:44,340
+كنيسة كنيسة كنيسة كنيسة كنيسة كنيسة كنيسة كنيسة
+
+239
+00:18:44,340 --> 00:18:45,120
+كنيسة كنيسة كنيسة كنيسة كنيسة كنيسة كنيسة كنيسة
+
+240
+00:18:45,120 --> 00:18:54,680
+كنيسة كنيسة كنيسة كنيسة كنيسة كنيسة كنيسة كنيسة
+
+241
+00:18:54,680 --> 00:18:59,070
+كنيثم لا أستطيع أن أقنع هذا التجارب لا أستطيع أن
+
+242
+00:18:59,070 --> 00:19:02,470
+أقول له أنك يجب أن تذهب إلى الوظيفة لأن الوظيفة
+
+243
+00:19:02,470 --> 00:19:05,450
+كانت تعمل لأجلي فأنا سأحصل على وظيفة كامة فأنا
+
+244
+00:19:05,450 --> 00:19:08,910
+سأحصل على وظيفة كامة فأنا سأحصل على وظيفة كامة
+
+245
+00:19:08,910 --> 00:19:16,730
+فأنا سأحصل علىnow this slide thirteen will have a
+
+246
+00:19:16,730 --> 00:19:19,610
+definition of a جنسي biostable this by the way
+
+247
+00:19:19,610 --> 00:19:22,150
+will not be included in the exam this is slide
+
+248
+00:19:22,150 --> 00:19:25,230
+only this definition will not be included I want
+
+249
+00:19:25,230 --> 00:19:28,890
+somebody to read it for me someone to read it loud
+
+250
+00:19:28,890 --> 00:19:36,330
+loud you go on binding ملزم
+
+251
+00:19:46,050 --> 00:19:51,750
+لو in fact there is no formal agency in fact there
+
+252
+00:19:51,750 --> 00:19:59,190
+is no agency in fact in such
+
+253
+00:19:59,190 --> 00:20:06,100
+cases the distance of an agency may bepresumed
+
+254
+00:20:06,100 --> 00:20:17,620
+افترض يعني good
+
+255
+00:20:17,620 --> 00:20:21,420
+so this what I was explaining just to you few
+
+256
+00:20:21,420 --> 00:20:24,460
+minutes ago this is the meaning of agents by
+
+257
+00:20:24,460 --> 00:20:27,380
+students I mean this slide only only this slide
+
+258
+00:20:27,380 --> 00:20:30,940
+will not be included in the exam because we did
+
+259
+00:20:30,940 --> 00:20:33,260
+explain it in the slide number twelve number
+
+260
+00:20:33,260 --> 00:20:34,100
+number eleven
+
+261
+00:20:37,370 --> 00:20:42,230
+نذهب للثالث مرة و هي الوثيقة بفرصة مواجهة مواجهة
+
+262
+00:20:42,230 --> 00:20:45,750
+مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة
+
+263
+00:20:45,750 --> 00:20:48,170
+مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة
+
+264
+00:20:48,170 --> 00:20:50,770
+مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة
+
+265
+00:20:50,770 --> 00:20:51,750
+مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة
+
+266
+00:20:51,750 --> 00:20:54,510
+مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة مواجهة
+
+267
+00:20:54,510 --> 00:20:59,270
+مواجهة مواجهة مواجهة
+
+268
+00:20:59,270 --> 00:21:03,570
+مواج
+
+269
+00:21:04,750 --> 00:21:11,670
+وأشياء أخرى لشخصين يتعاملون مع الوظيفة يجب أن نأكد
+
+270
+00:21:11,670 --> 00:21:18,050
+أن المستخدمين سيكونون حماسين ووظيفة هي وظيفة وهو
+
+271
+00:21:18,050 --> 00:21:23,910
+يعمل لأسلوب ووظيفة ستعطي ووظيفة ستكون قابلة
+
+272
+00:21:23,910 --> 00:21:28,890
+للمستخدم لذا يجب أن نحمي المستخدمين لدينا اثنين
+
+273
+00:21:28,890 --> 00:21:34,210
+حالات مثل هذه اثنين حالات رقم واحد و رقم اثنين هنا
+
+274
+00:21:35,830 --> 00:21:40,390
+أولا مصادر partners في هذه الصفحة في هذا النقطة
+
+275
+00:21:40,390 --> 00:21:43,710
+سوف ننظر إليها مرة أخرى يوم الشهر الأول يوم الشهر
+
+276
+00:21:43,710 --> 00:21:44,570
+الأول يوم الشهر الأولي يوم الشهر الأولي يوم الشهر
+
+277
+00:21:44,570 --> 00:21:44,830
+الأولي يوم الشهر الأولي يوم الشهر الأولي يوم الشهر
+
+278
+00:21:44,830 --> 00:21:46,050
+الأولي يوم الشهر الأولي يوم الشهر الأولي يوم الشهر
+
+279
+00:21:46,050 --> 00:21:47,550
+الأولي يوم الشهر الأولي يوم الشهر الأولي يوم الشهر
+
+280
+00:21:47,550 --> 00:21:47,550
+الأولي يوم الشهر الأولي يوم الشهر الأولي يوم الشهر
+
+281
+00:21:47,550 --> 00:21:50,650
+الأولي يوم الشهر الأولي يوم الشهر الأولي يوم الشهر
+
+282
+00:21:50,650 --> 00:21:53,650
+الأولي يوم الشهر الأولي يوم الشهر الأولي يوم الشهر
+
+283
+00:21:53,650 --> 00:21:55,930
+الأولي يوم الشهر الأولي ي
+
+284
+00:22:03,100 --> 00:22:05,500
+إذا كان لدينا شركة عادية اذا كان لدينا شركة عادية
+
+285
+00:22:05,500 --> 00:22:07,780
+اذا كان لدينا شركة عادية اذا كان لدينا شركة عادية
+
+286
+00:22:07,780 --> 00:22:11,380
+اذا كان لدينا شركة عادية اذا كان لدينا شركة عادية
+
+287
+00:22:11,380 --> 00:22:12,680
+اذا كان لدينا شركة عادية اذا كان لدينا شركة عادية
+
+288
+00:22:12,680 --> 00:22:12,680
+اذا كان لدينا شركة عادية اذا كان لدينا شركة عادية
+
+289
+00:22:12,680 --> 00:22:12,680
+اذا كان لدينا شركة عادية اذا كان لدينا شركة عادية
+
+290
+00:22:12,680 --> 00:22:12,900
+اذا كان لدينا شركة عادية اذا كان لدينا شركة عادية
+
+291
+00:22:12,900 --> 00:22:15,040
+اذا كان لدينا شركة عادية اذا كان لدينا شركة عادية
+
+292
+00:22:15,040 --> 00:22:20,020
+اذا كان لدينا شركة عادية اذا كان لدينا شركة عادية
+
+293
+00:22:20,020 --> 00:22:31,940
+اذا كان لدينا شرك
+
+294
+00:22:32,530 --> 00:22:40,250
+partner and a is agent so each one of them is
+
+295
+00:22:40,250 --> 00:22:43,150
+called partner at the same time each one of them
+
+296
+00:22:43,150 --> 00:22:47,470
+is called agents so let's say that all of you here
+
+297
+00:22:47,470 --> 00:22:52,190
+are partners in one partnership so every student
+
+298
+00:22:52,190 --> 00:22:57,330
+of you is a partner and everyone is an agent so
+
+299
+00:22:57,330 --> 00:23:02,900
+the action and activities of awill bind a b c d
+
+300
+00:23:02,900 --> 00:23:07,260
+all of them and activities we do here will bind
+
+301
+00:23:07,260 --> 00:23:12,380
+all of us i can be a partner as an a at the same
+
+302
+00:23:12,380 --> 00:23:15,580
+time i'm an agent the same thing for the c for c
+
+303
+00:23:15,580 --> 00:23:20,320
+or d or b so every one of them is partner شريك an
+
+304
+00:23:20,320 --> 00:23:24,860
+agent where is the principal who's the principal
+
+305
+00:23:24,860 --> 00:23:32,170
+so if each one of them is an agentكلهم جميعا جميعا
+
+306
+00:23:32,170 --> 00:23:38,270
+يكونوا مصطلح افضل، افضل، افضل، افضل، افضل، افضل،
+
+307
+00:23:38,270 --> 00:23:38,270
+افضل، افضل، افضل، افضل، افضل، افضل، افضل، افضل،
+
+308
+00:23:38,270 --> 00:23:39,750
+افضل، افضل، افضل، افضل، افضل، افضل، افضل، افضل،
+
+309
+00:23:39,750 --> 00:23:40,510
+افضل، افضل، افضل، افضل، افضل، افضل، افضل، افضل،
+
+310
+00:23:40,510 --> 00:23:42,450
+افضل، افضل، افضل، افضل، افضل، افضل، افضل، افضل،
+
+311
+00:23:42,450 --> 00:23:49,390
+افضل، افضل، افضل، اgives me the authority to work
+
+312
+00:23:49,390 --> 00:23:53,070
+as an agent so any action I will do as an agent
+
+313
+00:23:53,070 --> 00:23:59,770
+will bind all of us as partners as partners at the
+
+314
+00:23:59,770 --> 00:24:04,750
+same time all of us we have joint and several
+
+315
+00:24:04,750 --> 00:24:09,630
+liabilities what joint all of us here responsible
+
+316
+00:24:09,630 --> 00:24:16,460
+liableلأي خسارة للمستخدمين ABCD مصادر جميعهم
+
+317
+00:24:16,460 --> 00:24:21,420
+سيكونوا مقابلين للمستخدم مجتمعيا مجتمعيا معايا و
+
+318
+00:24:21,420 --> 00:24:25,340
+لدينا في نفس الوقت عديد من المقابلين كل واحد
+
+319
+00:24:25,340 --> 00:24:32,000
+بشخصيه سيكون مسؤول عن المستخدم لذلك المستخدم او
+
+320
+00:24:32,000 --> 00:24:37,340
+المجتمع الثالث يستطيع ان يسحب اي واحد منهم بشخصيه
+
+321
+00:24:39,400 --> 00:24:43,340
+إذا كنت أنا كشخص مستخدم، فسأبحث عن الوضع هنا، إذا
+
+322
+00:24:43,340 --> 00:24:51,880
+كان بي كشخص مستخدم، إذا كان كشخص مستخدم، إذا كان
+
+323
+00:24:51,880 --> 00:24:54,220
+كشخص مستخدم، إذا كان كشخص مستخدم، إذا كان كشخص
+
+324
+00:24:54,220 --> 00:24:54,220
+مستخدم، إذا كان كشخص مستخدم، إذا كان كشخص مستخدم،
+
+325
+00:24:54,220 --> 00:24:54,220
+إذا كان كشخص مستخدم، إذا كان كشخص مستخدم، إذا كان
+
+326
+00:24:54,220 --> 00:24:54,220
+كشخص مستخدم، إذا كان كشخص مستخدم، إذا كان كشخص
+
+327
+00:24:54,220 --> 00:24:55,060
+مستخدم، إذا كان كشخص مستخدم، إذا كان كشخص مستخدم،
+
+328
+00:24:55,060 --> 00:25:04,180
+إذا كان كشخص مستخدم، إذا كان كشخص مستخدم، إذا كان
+
+329
+00:25:04,180 --> 00:25:10,700
+كبعض منهم، يعتمد على الوضع انه يعتمد على المستخدم
+
+330
+00:25:10,700 --> 00:25:17,380
+فهذا هو رقم واحد رقم اثنان هو اننا لدينا بعض الناس
+
+331
+00:25:17,380 --> 00:25:25,120
+نفهم هنا ان هذه المشاركين لديها حكومة من موقعهم من
+
+332
+00:25:25,120 --> 00:25:31,520
+موقعهم كمشاركين رقم اثنان نجده في الشركات الشركات
+
+333
+00:25:32,820 --> 00:25:36,660
+في الشركات العامة وخاصة في الشركات العامة وخاصة في
+
+334
+00:25:36,660 --> 00:25:36,820
+الشركات العامة وخاصة في الشركات العامة وخاصة في
+
+335
+00:25:36,820 --> 00:25:37,860
+الشركات العامة وخاصة في الشركات العامة وخاصة في
+
+336
+00:25:37,860 --> 00:25:38,860
+الشركات العامة وخاصة في الشركات العامة وخاصة في
+
+337
+00:25:38,860 --> 00:25:40,380
+الشركات العامة وخاصة في الشركات العامة وخاصة في
+
+338
+00:25:40,380 --> 00:25:41,880
+الشركات العامة وخاصة في الشركات العامة وخاصة في
+
+339
+00:25:41,880 --> 00:25:43,700
+الشركات العامة وخاصة في الشركات العامة وخاصة في
+
+340
+00:25:43,700 --> 00:25:43,820
+الشركات العامة وخاصة في الشركات العامة وخاصة في
+
+341
+00:25:43,820 --> 00:25:44,920
+الشركات العامة وخاصة في الشركات العامة وخاصة في
+
+342
+00:25:44,920 --> 00:25:52,700
+الشركات العامة وخاصة في الشركات العامة وخاصة في
+
+343
+00:25:52,700 --> 00:25:55,720
+الشركات
+
+344
+00:25:57,710 --> 00:26:00,890
+إذا كان لدينا شركة و في هذه الشركة لدينا 2000
+
+345
+00:26:00,890 --> 00:26:04,670
+موظفين هل تعتقد أن كل واحد منهم يمكن أن يتصرف
+
+346
+00:26:04,670 --> 00:26:18,070
+كمشروع؟ لا؟ لماذا لا؟ نعم؟ لماذا نعم؟ التشريك هو
+
+347
+00:26:18,070 --> 00:26:22,830
+حالة مختلفة، ليس مثل شركة تشريك يحتوي على عدد صغير
+
+348
+00:26:22,830 --> 00:26:26,650
+من الناسهم يكونوا يكونوا يكونوا يكونوا يكونوا
+
+349
+00:26:26,650 --> 00:26:29,110
+يكونوا يكونوا يكونوا يكونوا يكونوا يكونوا يكونوا
+
+350
+00:26:29,110 --> 00:26:31,110
+يكونوا يكونوا يكونوا يكونوا يكونوا يكونوا يكونوا
+
+351
+00:26:31,110 --> 00:26:31,270
+يكونوا يكونوا يكونوا يكونوا يكونوا يكونوا يكونوا
+
+352
+00:26:31,270 --> 00:26:31,490
+يكونوا يكونوا يكونوا يكونوا يكونوا يكونوا يكونوا
+
+353
+00:26:31,490 --> 00:26:32,370
+يكونوا يكونوا يكونوا يكونوا يكونوا يكونوا يكونوا
+
+354
+00:26:32,370 --> 00:26:32,430
+يكونوا يكونوا يكونوا يكونوا يكونوا يكونوا يكونوا
+
+355
+00:26:32,430 --> 00:26:33,250
+يكونوا يكونوا يكونوا يكونوا يكونوا يكونوا يكونوا
+
+356
+00:26:33,250 --> 00:26:34,030
+يكونوا يكونوا يكونوا يكونوا يكونوا يكونوا يكونوا
+
+357
+00:26:34,030 --> 00:26:36,350
+يكونوا يكونوا يكونوا يكونوا يكونوا يكونوا يكونوا
+
+358
+00:26:36,350 --> 00:26:42,170
+يكونوا يكونوا يكونوا
+
+359
+00:26:42,170 --> 00:26:47,630
+يكونوا يكونوا يكونوا
+
+360
+00:26:47,630 --> 00:26:49,670
+ي
+
+361
+00:26:51,490 --> 00:26:56,750
+I think most of the corporation has management and
+
+362
+00:26:56,750 --> 00:27:01,130
+has other people and they have a lot of employees
+
+363
+00:27:01,130 --> 00:27:06,290
+so we can't know yes only senior only senior
+
+364
+00:27:06,290 --> 00:27:09,930
+employees decision with decision making authority
+
+365
+00:27:09,930 --> 00:27:12,350
+what decision making authority someone in the
+
+366
+00:27:12,350 --> 00:27:15,690
+senior level like executive managers executive
+
+367
+00:27:15,690 --> 00:27:20,050
+directors they can make decisions on behalf of
+
+368
+00:27:20,050 --> 00:27:23,870
+their companySo the corporation is the principal
+
+369
+00:27:23,870 --> 00:27:29,070
+and the senior employees are agents working for
+
+370
+00:27:29,070 --> 00:27:32,150
+that corporation here if you can read it, can you
+
+371
+00:27:32,150 --> 00:27:33,550
+read it؟وأيه الرسالة؟
+
+372
+00:27:52,700 --> 00:27:55,920
+it's not bind, it has a different meaning بند يعني
+
+373
+00:27:55,920 --> 00:28:03,480
+ينحني ينحني it's bind okay
+
+374
+00:28:03,480 --> 00:28:07,240
+now we have to move to the last point of this
+
+375
+00:28:07,240 --> 00:28:10,500
+slide here last point see this is not much
+
+376
+00:28:10,500 --> 00:28:13,680
+connected number three it's talking about
+
+377
+00:28:13,680 --> 00:28:20,040
+ratification acceptance but comes later in a later
+
+378
+00:28:20,040 --> 00:28:25,370
+stage after we make athe deal or transaction like
+
+379
+00:28:25,370 --> 00:28:30,010
+if you have somebody as a friend relative someone
+
+380
+00:28:30,010 --> 00:28:33,670
+you know and that person has has made a
+
+381
+00:28:33,670 --> 00:28:37,830
+transaction on your behalf with no consent and
+
+382
+00:28:37,830 --> 00:28:42,070
+even if your agent as an agent has exceeded
+
+383
+00:28:42,070 --> 00:28:47,450
+exceeded the agency and the authority and he or
+
+384
+00:28:47,450 --> 00:28:52,640
+she was acting with no with no authorityماذا
+
+385
+00:28:52,640 --> 00:28:56,980
+يمكننا أن نفعل هنا؟ احد مثلا اه انا هنا لدي سيارتي
+
+386
+00:28:56,980 --> 00:29:03,240
+لدي واحد من أصدقائي اتركت سيارتي و عملتي معه لأثق
+
+387
+00:29:03,240 --> 00:29:08,400
+.. كنت أثق في ذلك الشخص و أتركت البلد لأسبوعين
+
+388
+00:29:08,400 --> 00:29:15,260
+عندما عودت و وجدت أن ذلك الشخص كان يدفع على حسابي
+
+389
+00:29:16,570 --> 00:29:21,770
+هو أو هي قد فعلوا بعض التجارب و أنا لم أعرف عنهم و
+
+390
+00:29:21,770 --> 00:29:26,110
+لم أعطيهم الحكم على ذلك الشخص هل سأقبل هذا التعامل
+
+391
+00:29:26,110 --> 00:29:34,010
+و هل سأكون مخطط او لا؟ ماذا تعتقد؟ أحدهم ليس عملي
+
+392
+00:29:34,010 --> 00:29:35,150
+ليس لديه حكم
+
+393
+00:29:39,280 --> 00:29:42,840
+الان نعرف من البداية ان اذا اعطيت اي شخص اتصالي
+
+394
+00:29:42,840 --> 00:29:46,380
+يكون ذلك الشخص مصطلحي و هو او هي ستعمل على مجلدي
+
+395
+00:29:46,380 --> 00:29:51,940
+اذا كان شخص ما لا يعمل على مجلدي مثلا ماهو اسمك؟
+
+396
+00:29:51,940 --> 00:29:57,720
+هودا هودا اقول انها أختي وانا اثق هنا وانا اترك
+
+397
+00:29:57,720 --> 00:30:04,020
+بعض .. ليس حاجات .. بعض اشيائي اشيائي مع هوداو
+
+398
+00:30:04,020 --> 00:30:09,440
+عندما عدت من أبرارود و اكتشفت أن هودة قامت بتسليح
+
+399
+00:30:09,440 --> 00:30:14,800
+بعض أجهزتي و بعض مجموعاتي، فقامت بتسليحهم، في هذه
+
+400
+00:30:14,800 --> 00:30:19,460
+الحالة، فالأمر مطلوب مني، مطلوب مني، أستطيع أن
+
+401
+00:30:19,460 --> 00:30:24,630
+أقبل هذه التجارة أو أستطيع أن أرفضهالو انا اقفز
+
+402
+00:30:24,630 --> 00:30:29,010
+الترجمة انا استطيع ان اخذ جمهوري من بعيد انا
+
+403
+00:30:29,010 --> 00:30:31,830
+استطيع ان اخذ جمهوري من بعيد من اي شخص لانهم
+
+404
+00:30:31,830 --> 00:30:35,570
+ملعقين لي وليس له وليس لهذا الشخص اذا رحلت سيارتي
+
+405
+00:30:35,570 --> 00:30:40,250
+معه وقالت انها قامت بتسجيلها بصراحة انها بصراحة
+
+406
+00:30:40,250 --> 00:30:41,710
+انها بصراحة انها بصراحة انها بصراحة انها بصراحة
+
+407
+00:30:41,710 --> 00:30:42,570
+انها بصراحة انها بصراحة انها بصراحة انها بصراحة
+
+408
+00:30:42,570 --> 00:30:45,150
+انها بصراحة انها بصراحة انها بصراحة انها بصراحة
+
+409
+00:30:45,150 --> 00:30:52,470
+انها بصراحة انها بصراحة انها بصراحة انها
+
+410
+00:30:52,470 --> 00:31:00,450
+بصراحة انهاو كانت تدفع بدون أن تخبرني .. حتى
+
+411
+00:31:00,450 --> 00:31:05,610
+لو أستطيع أن أموالي ذلك الشخص ثالث مجتمع أو أعطيه
+
+412
+00:31:05,610 --> 00:31:09,590
+المال مرة أخرى، فهو بخير، على الأقل لدينا بعض
+
+413
+00:31:09,590 --> 00:31:13,110
+الحالات هنا و بعض الحالات .. أعني السيارة ليست
+
+414
+00:31:13,110 --> 00:31:17,870
+سيارته، أعني في هذه الحالة، الأسوأ مع ذلك الشخص هم
+
+415
+00:31:17,870 --> 00:31:22,590
+منيshe was just a trusted person I gave her
+
+416
+00:31:22,590 --> 00:31:25,130
+something she was not an agent and she was not
+
+417
+00:31:25,130 --> 00:31:27,730
+pretending to be my agent but in this case it's my
+
+418
+00:31:27,730 --> 00:31:31,150
+choice I can refuse I can accept and most likely I
+
+419
+00:31:31,150 --> 00:31:34,570
+mean if I accept it if I accept the transaction
+
+420
+00:31:34,570 --> 00:31:39,270
+this is something called ratification you know it
+
+421
+00:31:39,270 --> 00:31:47,390
+yeah notify sorry implicitly or implicitly ratify
+
+422
+00:31:47,390 --> 00:31:48,630
+يصادق
+
+423
+00:31:50,400 --> 00:31:57,120
+عند إعطاء إعافة أو إقرار هذا سيكون قبل أن تقوم بأي
+
+424
+00:31:57,120 --> 00:32:03,340
+قرار قبل أن تقوم الوظيفة بأي قرار ولكن عندما يقبل
+
+425
+00:32:03,340 --> 00:32:09,740
+قرار بعد ان تم تفعله هذا ما يسمى راتيفيكاشين
+
+426
+00:32:09,740 --> 00:32:14,120
+مصادقة يعني انها إعافة أو إقرار في هذه الحالة
+
+427
+00:32:14,120 --> 00:32:20,910
+القرار سيكون بخيروأنا سأكون كمسؤول ومسؤول ومقابل
+
+428
+00:32:20,910 --> 00:32:25,810
+كما لو أنني قد أعطيت إقبالي قبلها كما لو كان هناك
+
+429
+00:32:25,810 --> 00:32:30,830
+مجلس نفس الشيء فإقبال
+
+430
+00:32:30,830 --> 00:32:38,290
+المسؤول يمكن أن يكون قبل أن يتم التجارب بين المجلس
+
+431
+00:32:38,290 --> 00:32:43,770
+والثالث الشركة ولكن في بعض الحالاتفي بعض الحالات،
+
+432
+00:32:43,770 --> 00:32:46,450
+المشرف يمكن أن يتعامل بدون إعادة، والمشرف يمكن أن
+
+433
+00:32:46,450 --> 00:32:53,430
+يتعامل بدون إقبال القواعد، وفي هذه الحالة، هذا
+
+434
+00:32:53,430 --> 00:32:59,990
+الاتفاق بين المشرف والثالث الشركةهو سيقوم بمقاومة
+
+435
+00:32:59,990 --> 00:33:05,430
+المصطلح فقط و فقط إذا اقبلت المقاومة إذا اعطفها و
+
+436
+00:33:05,430 --> 00:33:17,490
+إذا اعطفها هذا يعني انها اعطفة اعطفها إذا اعطفها
+
+437
+00:33:17,490 --> 00:33:19,770
+إذا اعطفها إذا إعطفها إعطفها إعطفها إعطفها إعطفها
+
+438
+00:33:19,770 --> 00:33:22,290
+إعطفها إعطفها إعطفها إعطفها إعطفها إعطفها إعطفها
+
+439
+00:33:22,290 --> 00:33:24,790
+إعطفها إعطفها إعطفها إعطفها إعطفها إعطفها إعطفها
+
+440
+00:33:24,790 --> 00:33:25,630
+إعطفها إعطفها إعطفها إعطفها إعطفها إعطفها إعطفها
+
+441
+00:33:25,630 --> 00:33:28,080
+إعطفها إعطفها إعطفهاو في المستقبل هذا الشخص يستطيع
+
+442
+00:33:28,080 --> 00:33:34,620
+ان يستمر في فعالة التجارب التي هي نفسها نحتاج أن
+
+443
+00:33:34,620 --> 00:33:40,500
+نتحرك قليلا الان لننظر إلى الواضحيات مرة أخرى كما
+
+444
+00:33:40,500 --> 00:33:43,900
+قلت في هذا الحلقه اثنان أهم نقطة ننظر إلى الواضحة
+
+445
+00:33:43,900 --> 00:33:48,680
+و الواضحة نحن سننظر .. يجب أن نرى عملياتنا
+
+446
+00:33:48,680 --> 00:33:52,260
+عملياتنا ما يجب أن يفعله الرئيس و ما يجب أن يفعله
+
+447
+00:33:52,260 --> 00:33:56,410
+الوظيفةولكن يجب أن ننظر الان لعبادة .. لعبادة هي
+
+448
+00:33:56,410 --> 00:34:03,170
+شيء مهم .. لعبادة .. ماذا يعني لعبادة؟
+
+449
+00:34:03,170 --> 00:34:07,550
+لعبادة
+
+450
+00:34:07,550 --> 00:34:12,010
+.. لعبادة .. لعبادة .. لعبادة .. لعبادة .. لعبادة
+
+451
+00:34:12,010 --> 00:34:16,610
+.. لعبادة .. لعبادة .. لعبادة .. لعبادة .. لعبادة
+
+452
+00:34:16,610 --> 00:34:17,830
+.. لعبادة ..
+
+453
+00:34:24,990 --> 00:34:29,470
+أولا ننظر إلى قيمة الوظيفة للوظيفة الوظيفة للوظيفة
+
+454
+00:34:29,470 --> 00:34:39,510
+للوظيفة شخص ما لديه المال والمال والعمل وانه لديه
+
+455
+00:34:39,510 --> 00:34:45,150
+شخص ما يعمل على حسابه الوظيفة الوظيفة الوظيفة
+
+456
+00:34:45,150 --> 00:34:47,690
+الوظيفة الوظيفة الوظيفة الوظيفة الوظيفة الوظيفة
+
+457
+00:34:47,690 --> 00:34:48,190
+الوظيفة الوظيفة الوظيفة الوظيفة الوظيفة الوظيفة
+
+458
+00:34:48,190 --> 00:34:50,210
+الوظيفة الوظيفة الوظيفة الوظيفة الوظيفة الوظيفة
+
+459
+00:34:50,210 --> 00:34:51,650
+الوظيفة الوظيفة الوظيفة الوظيفة الوظيفة الوظيفة
+
+460
+00:34:51,650 --> 00:34:57,320
+الوظيفة الوظيفة الوظيفة الوظيفةI would be liable
+
+461
+00:34:57,320 --> 00:35:00,640
+for any action she make my liability means
+
+462
+00:35:00,640 --> 00:35:04,020
+responsibility towards her if she loses money I
+
+463
+00:35:04,020 --> 00:35:07,580
+would have to compensate what kind of money what
+
+464
+00:35:07,580 --> 00:35:12,460
+kind of money as long as here agent was acting my
+
+465
+00:35:12,460 --> 00:35:16,480
+agent as a principal myself as long as my agent
+
+466
+00:35:16,480 --> 00:35:20,660
+was acting on my behalf within the authority
+
+467
+00:35:20,660 --> 00:35:26,800
+actual authorityprincipal will indemnify .. what
+
+468
+00:35:26,800 --> 00:35:33,140
+indemnify .. compensate .. بي .. will indemnify
+
+469
+00:35:33,140 --> 00:35:37,740
+the agent for payments .. compensate or بي .. make
+
+470
+00:35:37,740 --> 00:35:43,180
+payments .. make payments .. for whom .. for ..
+
+471
+00:35:43,180 --> 00:35:45,820
+for the agent .. but what kind .. the question is
+
+472
+00:35:45,820 --> 00:35:49,560
+what kind of payments principal will pay .. what
+
+473
+00:35:49,560 --> 00:35:51,600
+kind of money ..
+
+474
+00:36:06,910 --> 00:36:10,190
+Payments were made during the course of
+
+475
+00:36:10,190 --> 00:36:13,930
+relationship agent was acting making transactions
+
+476
+00:36:13,930 --> 00:36:18,170
+with customers the agent paid some money for the
+
+477
+00:36:18,170 --> 00:36:21,110
+transactions he paid that money to complete the
+
+478
+00:36:21,110 --> 00:36:25,650
+deal on behalf ofبالنسبة للعامل في هذه الحالة
+
+479
+00:36:25,650 --> 00:36:29,770
+العامل يجب أن يقوم باستخدام ويجب أن يقوم باستخدام
+
+480
+00:36:29,770 --> 00:36:32,350
+ويجب أن يقوم باستخدام ويجب أن يقوم باستخدام ويجب
+
+481
+00:36:32,350 --> 00:36:36,990
+أن يقوم باستخدام ويجب أن يقوم باستخدام ويجب أن
+
+482
+00:36:36,990 --> 00:36:40,770
+يقوم باستخدام ويجب
+
+483
+00:36:40,770 --> 00:36:40,950
+أن يقوم باستخدام ويجب أن يقوم باستخدام ويجب أن
+
+484
+00:36:40,950 --> 00:36:41,570
+يقوم باستخدام ويجب أن يقوم باستخدام ويجب أن يقوم
+
+485
+00:36:41,570 --> 00:36:45,590
+باستخدام ويجب أن يقوم باستخدام ويجب أن يقوم
+
+486
+00:36:45,590 --> 00:36:51,820
+باستخدام ويجب أن يقوم باستخفي حالات مثلها و حالات
+
+487
+00:36:51,820 --> 00:36:54,780
+أخرى و حتى حالات أخرى، يجب أن يقوم الوظيفة
+
+488
+00:36:54,780 --> 00:36:56,400
+باستخدام الوظيفة، يجب أن يقوم باستخدام الوظيفة،
+
+489
+00:36:56,400 --> 00:36:57,500
+يجب أن يقوم باستخدام الوظيفة، يجب أن يقوم باستخدام
+
+490
+00:36:57,500 --> 00:36:59,720
+الوظيفة، يجب أن يقوم باستخدام الوظيفة، يجب أن يقوم
+
+491
+00:36:59,720 --> 00:37:03,220
+باستخدام
+
+492
+00:37:03,220 --> 00:37:05,060
+الوظيفة، يجب أن يقوم باستخدام الوظيفة، يجب أن يقوم
+
+493
+00:37:05,060 --> 00:37:11,460
+باستخدام الوظيفة، يجب أن يقوم باستخدام الوظيفة،
+
+494
+00:37:11,460 --> 00:37:18,120
+يجب أن يقوم باستخدام الوظيفة، يجب أن يلإعطاء العمل
+
+495
+00:37:18,120 --> 00:37:25,620
+كما قلت بينه كمشاركة ومشاركة فهو رقم واحد لعبادة
+
+496
+00:37:25,620 --> 00:37:31,180
+المشاركة للمشاركة رقم
+
+497
+00:37:31,180 --> 00:37:37,100
+اثنان لعبادة المشاركة للمشاركة ماذا تعتقد؟ هل يوجد
+
+498
+00:37:37,100 --> 00:37:44,850
+حالة فيها ان المشاركة يمكنها أن تخلص المشاركة؟ماذا
+
+499
+00:37:44,850 --> 00:37:48,330
+تعتقدين؟ هل يوجد حالة او حالة في الواقع في الواقع
+
+500
+00:37:48,330 --> 00:37:50,430
+في الواقع في الواقع في الواقع في الواقع في الواقع
+
+501
+00:37:50,430 --> 00:37:51,250
+في الواقع في الواقع في الواقع في الواقع في الواقع
+
+502
+00:37:51,250 --> 00:37:54,450
+في الواقع في الواقع في الواقع في الواقع في الواقع
+
+503
+00:37:54,450 --> 00:37:59,310
+في الواقع في الواقع في الواقع في الواقع في الواقع
+
+504
+00:37:59,310 --> 00:38:03,330
+في الواقع في الواقع في الواقع في الواقع في الواقع
+
+505
+00:38:03,330 --> 00:38:12,530
+في الواقع في الواقع في الواقع
+
+506
+00:38:15,360 --> 00:38:22,160
+إذا كان الشرطة تعمل باعتبار السلطة فهي بخير، لكن
+
+507
+00:38:22,160 --> 00:38:28,740
+إذا كان الشرطة تعمل خارج السلطة و كانت تعمل بدون
+
+508
+00:38:28,740 --> 00:38:33,880
+قوة و بدون سلطة من القواعد، فالشرطة ستكون مقابلة،
+
+509
+00:38:33,880 --> 00:38:39,320
+ثم يجب أن الشرطة تدفع القواعد لأي خسارةوكان لدينا
+
+510
+00:38:39,320 --> 00:38:42,420
+الكثير من الحالات في الحجر وكثير من الحاجات التي
+
+511
+00:38:42,420 --> 00:38:49,900
+لم يتبع أسلوب الاصطناع الاصطناعي هذا الشخص و هذه
+
+512
+00:38:49,900 --> 00:38:52,440
+السيدة لم تتبع كل شيء
+
+513
+00:38:55,680 --> 00:39:01,540
+وشيء خارج المعرفة قام بتجارب لماذا يجب أن أدفع
+
+514
+00:39:01,540 --> 00:39:08,520
+كمصطلح لأفعال من مجلسي ومجلسي لم يسمح ليه بالمعرفة
+
+515
+00:39:08,520 --> 00:39:13,000
+وربما يسبب فيه خسارة في هذه الحالة المجلس يجب أن
+
+516
+00:39:13,000 --> 00:39:18,910
+يساعد المصطلحهو يجب أن يكون مخلص للأساس هنا في هذه
+
+517
+00:39:18,910 --> 00:39:24,730
+الحالة الواجهة لديها حكومة اعتبارية مخلصة للأساس
+
+518
+00:39:24,730 --> 00:39:27,190
+لأي خسارة أو تدمير
+
+519
+00:39:40,850 --> 00:39:48,350
+الثالث هو كلاهما مصطلح و مصطلح مصطلح مصطلح مصطلح
+
+520
+00:39:48,350 --> 00:39:51,430
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+521
+00:39:51,430 --> 00:40:05,110
+مصطلح مصطلح مصطلح
+
+522
+00:40:06,220 --> 00:40:10,420
+أحاول ان اختلط بين الانتصارين لديه اتفاقين اولا
+
+523
+00:40:10,420 --> 00:40:14,600
+اتفاق الشركة و الثانوية اتفاق الشركة لشركة اتفاق
+
+524
+00:40:14,600 --> 00:40:16,680
+الشركة لشركة اتفاق الشركة لشركة اتفاق الشركة لشركة
+
+525
+00:40:16,680 --> 00:40:19,560
+اتفاق الشركة لشركة اتفاق الشركة لشركة اتفاق الشركة
+
+526
+00:40:19,560 --> 00:40:23,560
+لشركة اتفاق الشركة لشركة اتفاق الشركة لشركة اتفاق
+
+527
+00:40:23,560 --> 00:40:28,720
+الشركة لشركة اتفاق الشركة لشركة اتفاق الشركة لشركة
+
+528
+00:40:28,720 --> 00:40:32,920
+اتفاق الشركة لشركة اتفاق الشركة لشركة اتفاق الشركة
+
+529
+00:40:32,920 --> 00:40:37,880
+لشركة اتin one case .. it's not optional for you
+
+530
+00:40:37,880 --> 00:40:41,860
+like suing .. you know what is suing .. what does
+
+531
+00:40:41,860 --> 00:40:45,180
+it mean suing .. oh come on .. if this one word
+
+532
+00:40:45,180 --> 00:40:47,720
+you don't know just you have to tell me .. you
+
+533
+00:40:47,720 --> 00:40:51,340
+قاضي .. you قاضي .. بالمحكمة .. how can you pursue
+
+534
+00:40:51,340 --> 00:40:54,400
+the case .. a lawsuit .. do you understand what
+
+535
+00:40:54,400 --> 00:40:57,360
+I'm saying to you .. or it seems to me that some
+
+536
+00:40:57,360 --> 00:41:01,440
+of you do not understand what I'm saying .. isn't
+
+537
+00:41:01,440 --> 00:41:04,280
+it .. or you should tell me
+
+538
+00:41:07,380 --> 00:41:10,260
+how do you find it how much do you understand 70
+
+539
+00:41:10,260 --> 00:41:15,860
+80 percent 50 50 oh come on you have to be honest
+
+540
+00:41:15,860 --> 00:41:22,700
+70 70 how much 70 yes
+
+541
+00:41:27,810 --> 00:41:30,210
+it's more than that anyway listen one once we
+
+542
+00:41:30,210 --> 00:41:33,250
+finish today we're going to have time for 10 15
+
+543
+00:41:33,250 --> 00:41:37,570
+minutes to discuss the the way i explain things
+
+544
+00:41:37,570 --> 00:41:40,630
+and if you do understand what i'm saying or not
+
+545
+00:41:40,630 --> 00:41:43,550
+and if you want me to mix sometimes with arab
+
+546
+00:41:43,550 --> 00:41:51,110
+going to translate some words okay all right now
+
+547
+00:41:51,110 --> 00:41:56,090
+both of them principal and agent are liable
+
+548
+00:41:56,940 --> 00:42:02,720
+مسئولين، liable towards third party، third party
+
+549
+00:42:02,720 --> 00:42:06,720
+customer، السبونة أو العميل أو اقتراف التالت، he
+
+550
+00:42:06,720 --> 00:42:11,580
+or she can sue both of them at the same time،
+
+551
+00:42:11,580 --> 00:42:15,600
+joint، كلا، joint liabilityمع بعض او هو و هي
+
+552
+00:42:15,600 --> 00:42:19,380
+يستطيعون ايضا مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+553
+00:42:19,380 --> 00:42:19,980
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+554
+00:42:19,980 --> 00:42:20,480
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+555
+00:42:20,480 --> 00:42:23,080
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+556
+00:42:23,080 --> 00:42:23,200
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+557
+00:42:23,200 --> 00:42:32,620
+مجرد مجرد مجرد مجرد
+
+558
+00:42:32,620 --> 00:42:38,320
+مج
+
+559
+00:42:39,830 --> 00:42:44,790
+على حسب القرار كان يتبع كل المعلومات وكان لديه
+
+560
+00:42:44,790 --> 00:42:46,590
+اكتوار او اكتوار اكتوار اكتوار اكتوار اكتوار
+
+561
+00:42:46,590 --> 00:42:46,690
+اكتوار اكتوار اكتوار اكتوار اكتوار اكتوار اكتوار
+
+562
+00:42:46,690 --> 00:42:51,610
+اكتوار اكتوار اكتوار اكتوار اكتوار اكتوار اكتوار
+
+563
+00:42:51,610 --> 00:42:51,690
+اكتوار اكتوار اكتوار اكتوار اكتوار اكتوار اكتوار
+
+564
+00:42:51,690 --> 00:42:51,810
+اكتوار اكتوار اكتوار اكتوار اكتوار اكتوار اكتوار
+
+565
+00:42:51,810 --> 00:42:53,050
+اكتوار اكتوار اكتوار اكتوار اكتوار اكتوار
+
+566
+00:43:09,250 --> 00:43:12,670
+I was doing my job it's the company itself it's
+
+567
+00:43:12,670 --> 00:43:15,450
+the principal who's going to pay for that then the
+
+568
+00:43:15,450 --> 00:43:21,290
+agent will not be liable here as long as as long
+
+569
+00:43:21,290 --> 00:43:24,890
+as the transactions the transaction agreed within
+
+570
+00:43:24,890 --> 00:43:28,410
+the authority all these transactions were done by
+
+571
+00:43:28,410 --> 00:43:32,470
+the agent within the authority he had from the
+
+572
+00:43:32,470 --> 00:43:38,630
+principal number two a the agency was revealedكان
+
+573
+00:43:38,630 --> 00:43:43,370
+مضطر ان انا كشخص مصطلح و انا اتعامل على حسب شخص
+
+574
+00:43:43,370 --> 00:43:48,290
+اخر و هذا ليس عملي و انت يجب ان تفهم هذا و اذا اذا
+
+575
+00:43:48,290 --> 00:43:50,710
+كنت تريد ان تدفع يجب انت لا تدفعني انت يجب ان
+
+576
+00:43:50,710 --> 00:43:57,410
+تدفعي ايش؟ يجب ان تدفعي الرقم و في هذه اللحظة يجب
+
+577
+00:43:57,410 --> 00:44:00,070
+ان يكون اكتشاف اكتشاف الرقم
+
+578
+00:44:03,450 --> 00:44:07,910
+الاعتماد الاصطناعي يقول للمستخدم ان انا مجرد مجرد
+
+579
+00:44:07,910 --> 00:44:07,990
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+580
+00:44:07,990 --> 00:44:09,510
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+581
+00:44:09,510 --> 00:44:20,570
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+582
+00:44:20,570 --> 00:44:29,150
+مجرد
+
+583
+00:44:30,590 --> 00:44:32,910
+أو مجتمع ثالث ليس مجرد مجرد مجرد مجرد مجرد مجرد
+
+584
+00:44:32,910 --> 00:44:35,570
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+585
+00:44:35,570 --> 00:44:37,250
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+586
+00:44:37,250 --> 00:44:43,370
+مجرد مجرد مجرد
+
+587
+00:44:43,370 --> 00:44:51,250
+مجرد
+
+588
+00:45:11,020 --> 00:45:15,340
+when the agent will have liability towards the
+
+589
+00:45:15,340 --> 00:45:19,640
+third party when this situation will be
+
+590
+00:45:24,790 --> 00:45:28,710
+إذا كانت تتبع أو لا تتبع؟ لا تتبع، لا تتبع، لا
+
+591
+00:45:28,710 --> 00:45:31,330
+تتبع، لا تتبع، لا تتبع، لا تتبع، لا تتبع، لا تتبع،
+
+592
+00:45:31,330 --> 00:45:31,330
+لا تتبع، لا تتبع، لا تتبع، لا تتبع، لا تتبع، لا
+
+593
+00:45:31,330 --> 00:45:31,810
+تتبع، لا تتبع، لا تتبع، لا تتبع، لا تتبع، لا تتبع،
+
+594
+00:45:31,810 --> 00:45:32,850
+لا تتبع، لا تتبع، لا تتبع، لا تتبع، لا تتبع، لا
+
+595
+00:45:32,850 --> 00:45:32,850
+تتبع، لا تتبع، لا تتبع، لا تتبع، لا تتبع، لا تتبع،
+
+596
+00:45:32,850 --> 00:45:42,770
+لا تتبع، لا تتبع، لا تتبع،
+
+597
+00:45:42,770 --> 00:45:50,070
+لا تتبع، لا
+
+598
+00:45:50,070 --> 00:45:57,650
+تتبعOkay if the agent was not acting within the
+
+599
+00:45:57,650 --> 00:46:02,550
+authority and if the action of the agent has
+
+600
+00:46:02,550 --> 00:46:07,970
+affected the third party then the principal will
+
+601
+00:46:07,970 --> 00:46:11,370
+not be liable, the agent should compensate, the
+
+602
+00:46:11,370 --> 00:46:16,690
+agent should indemnify the whom
+
+603
+00:46:19,150 --> 00:46:23,190
+أنا لدي مثال مثل هذا ليس مثل هذا ولكن نحن نحن نحن
+
+604
+00:46:23,190 --> 00:46:23,950
+نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن
+
+605
+00:46:23,950 --> 00:46:26,010
+نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن
+
+606
+00:46:26,010 --> 00:46:27,630
+نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن
+
+607
+00:46:27,630 --> 00:46:27,950
+نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن
+
+608
+00:46:27,950 --> 00:46:28,090
+نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن
+
+609
+00:46:28,090 --> 00:46:34,190
+نحن نحن نحن نحن نحن
+
+610
+00:46:34,190 --> 00:46:45,990
+نحن
+
+611
+00:46:45,990 --> 00:46:50,410
+نللمدير في البنك يقول أننا اليوم لدينا هذا و هذا و
+
+612
+00:46:50,410 --> 00:46:56,030
+لدينا إدارة و إخراج واحد يوم واحد من مجلد الوظيفة
+
+613
+00:46:56,030 --> 00:47:03,850
+وجد فرصة من كثير من المال، الان من سيكون المسؤول
+
+614
+00:47:03,850 --> 00:47:08,230
+عن هذا؟ الوظيفة، يعني مجلد الوظيفة أو البنك؟ مجلد
+
+615
+00:47:08,230 --> 00:47:13,270
+الوظيفةانا لسه ان انا لسه ان انا لسه ان انا لسه ان
+
+616
+00:47:13,270 --> 00:47:14,270
+انا لسه ان انا لسه ان انا لسه ان انا لسه ان انا
+
+617
+00:47:14,270 --> 00:47:15,270
+لسه ان انا لسه ان انا لسه ان انا لسه ان انا لسه ان
+
+618
+00:47:15,270 --> 00:47:16,070
+انا لسه ان انا لسه ان انا لسه ان انا لسه ان انا
+
+619
+00:47:16,070 --> 00:47:16,830
+لسه ان انا لسه ان انا لسه ان انا لسه ان انا لسه ان
+
+620
+00:47:16,830 --> 00:47:17,950
+انا لسه ان انا لسه ان انا لسه ان انا لسه ان انا
+
+621
+00:47:17,950 --> 00:47:18,210
+لسه ان انا لسه ان انا لسه ان انا لسه ان انا لسه ان
+
+622
+00:47:18,210 --> 00:47:21,430
+انا لسه ان انا لسه ان انا لسه ان انا لسه ان انا
+
+623
+00:47:21,430 --> 00:47:27,070
+لسه ان انا لسه
+
+624
+00:47:27,070 --> 00:47:31,850
+ان اناوأنا قد رأيت بعض منهم .. لدي بعض القصص في
+
+625
+00:47:31,850 --> 00:47:36,110
+التي بعض مجلد الوظيفة يجب أن يقوموا بإيقافها، يجب
+
+626
+00:47:36,110 --> 00:47:40,050
+أن يقوموا بإنقاذ الوظيفة لأنهم فعلوا خطأ إنهم
+
+627
+00:47:40,050 --> 00:47:44,350
+أعطوا أكتر المال للمستخدم، للمستخدم أو ربما فقط
+
+628
+00:47:44,350 --> 00:47:48,990
+فقدروا المال أو فعلوا شيء غير صحيح، إذا فهذا أسببت
+
+629
+00:47:48,990 --> 00:47:54,290
+فخطأ للمستخدم أو للوظيفة، فهو خطأك كمستخدم يجب أن
+
+630
+00:47:54,290 --> 00:47:59,180
+تقوم بإيقافهيجب عليك أن تخلص المستخدم أو المستخدم
+
+631
+00:47:59,180 --> 00:48:03,420
+أو يجب عليك أن تخلص الرئيس نفسه، فهذا يعتمد على
+
+632
+00:48:03,420 --> 00:48:04,220
+حالته
+
+633
+00:48:15,070 --> 00:48:17,410
+الأن يجب أن ننظر إلى المقاطع، إذا كان هناك مال
+
+634
+00:48:17,410 --> 00:48:22,930
+إضافي، إذا كان هناك مال إضافي مع الوظيفة، فهناك
+
+635
+00:48:22,930 --> 00:48:25,710
+مفيد إضافي، لا يجب أن يكون المال دائما، يمكن أن
+
+636
+00:48:25,710 --> 00:48:29,730
+يكون مفيد إضافي، ثم ننظر إلى المقاطع، في هذه
+
+637
+00:48:29,730 --> 00:48:30,010
+الحالة
+
+638
+00:48:32,940 --> 00:48:37,920
+هذا المال قد يكون للمستخدم، يجب أن نحتفظ به، يجب
+
+639
+00:48:37,920 --> 00:48:41,580
+أن نحفظه في مكان ما حتى نجد شخص ما .. لأنك يجب أن
+
+640
+00:48:41,580 --> 00:48:44,880
+تتوقع أن شخص ما سيأتي إليك بعد بضعة أيام أو بضعة
+
+641
+00:48:44,880 --> 00:48:52,750
+أشهر ..هذا المال و عليك أن تدفعه لذلك، لذا عليك أن
+
+642
+00:48:52,750 --> 00:48:56,130
+تبقى .. أعني حتى إذا لم تجد شخص لاحقًا، ليس ..
+
+643
+00:48:56,130 --> 00:48:59,030
+أعني لا يوجد نظام حقيقي لذلك في هذه النقطة، أعني
+
+644
+00:48:59,030 --> 00:49:02,690
+يمكنك أن تبقى على أقل في بنك، في بنك نفسه، ليس
+
+645
+00:49:02,690 --> 00:49:04,570
+منك، انت فقط تعمل في بنك
+
+646
+00:49:15,120 --> 00:49:22,220
+ننظر إلى الوظائف ننتهي
+
+647
+00:49:22,220 --> 00:49:25,940
+من الوظائف باستخدام authority و liability واحد من
+
+648
+00:49:25,940 --> 00:49:30,000
+النقطات اللي ننظرها الأن هي الوظائف و الوظيفة و
+
+649
+00:49:30,000 --> 00:49:33,980
+الوظائف و الوظائف و الوظائف و الوظائف و الوظائف و
+
+650
+00:49:33,980 --> 00:49:34,680
+الوظائف و الوظائف و الوظائف و الوظائف و الوظائف و
+
+651
+00:49:34,680 --> 00:49:35,580
+الوظائف و الوظائف و الوظائف و الوظائف و الوظائف و
+
+652
+00:49:35,580 --> 00:49:37,720
+الوظائف و الوظائف و الوظائف و الوظائف و الوظائف و
+
+653
+00:49:37,720 --> 00:49:41,140
+الوظائف و الوظائف و الوظائف و الوظائف و الوظائف و
+
+654
+00:49:41,140 --> 00:49:44,940
+الوظائف و الوظائف و الوظماذا يجب أن نفعل؟ يجب أن
+
+655
+00:49:44,940 --> 00:49:52,080
+ننظر إلى العمليات المهمة عمليات عمليات عمليات
+
+656
+00:49:52,080 --> 00:49:55,200
+عمليات عمليات عمليات عمليات عمليات عمليات عمليات
+
+657
+00:49:55,200 --> 00:49:56,400
+عمليات عمليات عمليات عمليات عمليات عمليات عمليات
+
+658
+00:49:56,400 --> 00:49:57,840
+عمليات عمليات عمليات عمليات عمليات عمليات عمليات
+
+659
+00:49:57,840 --> 00:49:57,900
+عمليات عمليات عمليات عمليات عمليات عمليات عمليات
+
+660
+00:49:57,900 --> 00:49:57,900
+عمليات عمليات عمليات عمليات عمليات عمليات عمليات
+
+661
+00:49:57,900 --> 00:49:58,980
+عمليات عمليات عمليات عمليات عمليات عمليات عمليات
+
+662
+00:49:58,980 --> 00:50:08,260
+عمليات عمليات عمليات عمليات ع
+
+663
+00:50:08,780 --> 00:50:12,340
+principal duties , a principal what can he or she
+
+664
+00:50:12,340 --> 00:50:14,040
+do for the agent
+
+665
+00:50:41,580 --> 00:50:46,720
+is that basically principal has to give all
+
+666
+00:50:46,720 --> 00:50:49,540
+information all necessary information to the agent
+
+667
+00:50:49,540 --> 00:50:53,800
+what to dohow much should you charge the
+
+668
+00:50:53,800 --> 00:50:56,700
+customers, the qualities, the quantity,
+
+669
+00:50:57,440 --> 00:51:00,720
+description of the items, everything concern the
+
+670
+00:51:00,720 --> 00:51:04,100
+commodities and the transactions, all the
+
+671
+00:51:04,100 --> 00:51:07,800
+information needed, all information have to be
+
+672
+00:51:07,800 --> 00:51:12,540
+given to the agent, like somebody is appointing
+
+673
+00:51:12,540 --> 00:51:19,520
+Samiha to be an agentتعمل في شركة و تثق بها و هي
+
+674
+00:51:19,520 --> 00:51:23,320
+مهرجانة و جاءت في الأسبوع الأول لعمل في تلك الشركة
+
+675
+00:51:23,320 --> 00:51:26,600
+هل تتخيل أنها لن تكون لديها أي معلومات عن ماذا
+
+676
+00:51:26,600 --> 00:51:33,500
+تفعل؟ ماذا هي ستفعل بالضبط؟ هي ستحتاج لديها كل شيء
+
+677
+00:51:33,500 --> 00:51:38,780
+يتم إعطائه بأساس كل المعلومات المحتاجة لكي تستطيع
+
+678
+00:51:38,780 --> 00:51:44,970
+تسوي، تشتري، تعمل، تعمل التعاملات،كما قلت قبل كمية
+
+679
+00:51:44,970 --> 00:51:49,630
+و قيمة و قيمة و كيف تتعامل مع المستخدم كل شيء يجب
+
+680
+00:51:49,630 --> 00:51:58,290
+أن يكون موجود في مجلس من الأشخاص الاخرين هو المال
+
+681
+00:51:58,290 --> 00:52:03,810
+مجلس يعمل للمال، أليس كذلك؟ يجب أن يكون هناك نظام،
+
+682
+00:52:03,810 --> 00:52:08,710
+شيء يسمى كمشارة أو عمليات إذا تنظر إلى هذا، ليس
+
+683
+00:52:08,710 --> 00:52:13,930
+مثل ما يحصل في شركة شركةwe look at this next time
+
+684
+00:52:13,930 --> 00:52:18,310
+but we have to pay fees او we call it most likely
+
+685
+00:52:18,310 --> 00:52:22,210
+commission it's like a payment salary it's paid
+
+686
+00:52:22,210 --> 00:52:26,490
+for the agent working for somebody it's like an
+
+687
+00:52:26,490 --> 00:52:29,390
+employees it's not the same but at least you're
+
+688
+00:52:29,390 --> 00:52:32,290
+going to get the money as if somebody working as
+
+689
+00:52:32,290 --> 00:52:36,030
+an employee an agent you get commission this can
+
+690
+00:52:36,030 --> 00:52:39,760
+be monthly payment weekly paymentit can be
+
+691
+00:52:39,760 --> 00:52:43,420
+something per item it can be it can be a
+
+692
+00:52:43,420 --> 00:52:47,140
+percentage you know that it can be a percentage
+
+693
+00:52:47,140 --> 00:52:51,540
+like how many computers it can sell لنسبة اه i can
+
+694
+00:52:51,540 --> 00:52:54,960
+take like five percent and we have one of the most
+
+695
+00:52:54,960 --> 00:53:01,000
+difficult cases in how can we end end or terminate
+
+696
+00:53:01,000 --> 00:53:06,100
+the agency is that one you appoint somebody and it
+
+697
+00:53:06,100 --> 00:53:11,440
+will give that person a percentageثم سأقول له لا
+
+698
+00:53:11,440 --> 00:53:17,680
+أريدك أن تعمل مني بعد الأن كيف سأكون ذلك الشخص؟
+
+699
+00:53:17,680 --> 00:53:20,820
+سننظر إلى ذلك في وقت طويل ولكن على أية حال، يجب أن
+
+700
+00:53:20,820 --> 00:53:23,220
+تكون الواجهة أو الحفاظ بيد
+
+701
+00:53:28,370 --> 00:53:30,290
+الproblem is that we don't have many slides here,
+
+702
+00:53:30,390 --> 00:53:32,470
+I mean next time we have to take half of the
+
+703
+00:53:32,470 --> 00:53:35,130
+lecture next time for agency and the other half to
+
+704
+00:53:35,130 --> 00:53:37,130
+brief of the contract or maybe we can have
+
+705
+00:53:37,130 --> 00:53:40,130
+something new, well look what we gonna do next
+
+706
+00:53:40,130 --> 00:53:45,350
+time anyway we look at the agency duties, do you
+
+707
+00:53:45,350 --> 00:53:48,630
+want me to leave it for next time? leave it for
+
+708
+00:53:48,630 --> 00:53:54,110
+next time? what do you think?we still have time
+
+709
+00:53:54,110 --> 00:53:57,290
+okay we're gonna we're gonna stop here and we're
+
+710
+00:53:57,290 --> 00:54:00,250
+gonna have discussion now listen look at me we
+
+711
+00:54:00,250 --> 00:54:02,770
+will stop here we're gonna take discussions for
+
+712
+00:54:02,770 --> 00:54:06,790
+eight seven minutes discussion about the subject
+
+713
+00:54:06,790 --> 00:54:10,090
+evaluation and next time when we come we have to
+
+714
+00:54:10,090 --> 00:54:13,090
+complete or we have to complete by looking at
+
+715
+00:54:13,090 --> 00:54:16,310
+agents duties okay thanks for your time
+
diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/PsYXNOnkO_c.srt b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/PsYXNOnkO_c.srt
new file mode 100644
index 0000000000000000000000000000000000000000..e94d71e2bcb4f7c0890a8f1faedb1dda7fa49877
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/PsYXNOnkO_c.srt
@@ -0,0 +1,3374 @@
+
+1
+00:00:14,300 --> 00:00:17,700
+بسم الله الرحمن الرحيم السلام عليكم اليوم، what we have is a chapter
+
+2
+00:00:17,700 --> 00:00:24,320
+on three contracts. We have this chapter as one of the
+
+3
+00:00:24,320 --> 00:00:27,940
+main points we have to look at in this study, and
+
+4
+00:00:27,940 --> 00:00:33,120
+study كشخصية أساسية من القانون التجاري هو
+
+5
+00:00:33,120 --> 00:00:36,600
+واحد من المعاملات الرئيسية في القانون التجاري
+
+6
+00:00:36,600 --> 00:00:40,080
+وعندما ندرس القانون التجاري، ليس مهماً إن كان هذا يمكن أن
+
+7
+00:00:40,080 --> 00:00:42,780
+يكون في القانون التجاري أو القانون المدني، فنستطيع
+
+8
+00:00:42,780 --> 00:00:46,220
+أن نفهم كيف نستطيع أن نصنع قانوناً تجارياً، كيف نستطيع
+
+9
+00:00:46,220 --> 00:00:52,420
+أن نصنع قانوناً تجارياً بطريقة أساسية ومساعدة بين اتين
+
+10
+00:00:52,420 --> 00:00:57,480
+أو أكثر. شركات ليست مثل مؤسسة. في هذه القصة يجب أن
+
+11
+00:00:57,480 --> 00:01:19,760
+ننظر إلى two parts, two parties, A and B only, as
+
+12
+00:01:19,760 --> 00:01:22,320
+you can see that what we have in this chapter
+
+13
+00:01:22,320 --> 00:01:27,360
+simply is something we do use on a daily basis.
+
+14
+00:01:34,600 --> 00:01:38,820
+A contract is something we have most likely every
+
+15
+00:01:38,820 --> 00:01:44,940
+day, every week. Most of you make contracts on a
+
+16
+00:01:44,940 --> 00:01:47,580
+daily basis. When you buy a sandwich from the
+
+17
+00:01:47,580 --> 00:01:50,080
+canteen, when you buy a cup of coffee, when you
+
+18
+00:01:50,080 --> 00:01:53,600
+buy a cloth, a headscarf, when you pay the
+
+19
+00:01:53,600 --> 00:01:56,820
+taxi driver when he comes; all these are contracts.
+
+20
+00:01:56,820 --> 00:02:00,140
+So, how many times per day do we make contracts?
+
+21
+00:02:00,360 --> 00:02:03,910
+It’s many times. الكثير من الناس لا يعتبر هذه
+
+22
+00:02:03,910 --> 00:02:09,730
+الاتفاقات صحيحة لأننا فقط نعتمد أننا نفعل أفعالاً
+
+23
+00:02:09,730 --> 00:02:13,450
+إنها أفعال، ولكن هذه الأفعال في الحقيقة هي
+
+24
+00:02:13,450 --> 00:02:19,670
+اتفاقات صحيحة، اتفاقات مرتبطة صحيحة بين اتفاقات
+
+25
+00:02:19,670 --> 00:02:23,570
+اتفاقات اتفاقات اتفاقات اتفاقات اتفاقات بين
+
+26
+00:02:23,570 --> 00:02:27,610
+اتفاقات اتفاقات اتفاقات اتفاقات
+
+27
+00:02:30,120 --> 00:02:32,800
+What does “contract” mean in commercial law? How
+
+28
+00:02:32,800 --> 00:02:35,680
+can we establish it? What kind of conditions do we
+
+29
+00:02:35,680 --> 00:02:39,380
+need? What situations can affect the contract, the
+
+30
+00:02:39,380 --> 00:02:41,960
+existence of the contract? How can
+
+31
+00:02:41,960 --> 00:02:45,380
+we end it? How can we enforce it? How many parties
+
+32
+00:02:45,380 --> 00:02:48,340
+can we have? As you can see, that most likely you
+
+33
+00:02:48,340 --> 00:02:53,810
+have two parties, two persons, A and B. They can be
+
+34
+00:02:53,810 --> 00:02:56,690
+natural persons; they can be fictitious persons;
+
+35
+00:02:56,950 --> 00:03:00,170
+it can be a company; it can be an institute; it
+
+36
+00:03:00,170 --> 00:03:02,270
+can be an organization; it can be a human being;
+
+37
+00:03:02,530 --> 00:03:07,230
+anyone can make a contract. It’s not only sale; we
+
+38
+00:03:07,230 --> 00:03:10,950
+have many types of contracts, but the most common
+
+39
+00:03:10,950 --> 00:03:15,570
+type of contract is sale, sale of goods. You can
+
+40
+00:03:15,570 --> 00:03:19,210
+sell services; you can sell goods; you can rent; you
+
+41
+00:03:19,210 --> 00:03:22,890
+can hire; you can sign an insurance contract with a
+
+42
+00:03:22,890 --> 00:03:26,850
+company. There are many ways in which we can sign a
+
+43
+00:03:26,850 --> 00:03:29,810
+contract. We can make it… How can we define a
+
+44
+00:03:29,810 --> 00:03:33,130
+contract? It’s not difficult once we look at this
+
+45
+00:03:33,130 --> 00:03:37,090
+equation here: A and B. Somebody will make an offer
+
+46
+00:03:37,090 --> 00:03:41,890
+and the second will make an acceptance. Simply, if
+
+47
+00:03:41,890 --> 00:03:47,270
+you would like to buy a laptop،  أُعطي لك اللابتوب بـ 500$، وأنا أختار وأنت
+
+48
+00:03:47,270 --> 00:03:53,510
+تقوم بالموافقة. واحد من الجمهور يقوم باختيار والآخر
+
+49
+00:03:53,510 --> 00:03:58,050
+يقوم بالموافقة. لذا كلا الاثنين يقومون بشيء يُسمّى
+
+50
+00:03:58,050 --> 00:04:02,110
+موافقة، consent. Consent يعني موافقة من كلا الجانبين، كلا
+
+51
+00:04:02,110 --> 00:04:10,590
+الجانبين قاما بالموافقة، هذا الاختيار، موافقة
+
+52
+00:04:10,590 --> 00:04:12,730
+الاختيار to make the contract: offer and acceptance.
+
+53
+00:04:12,730 --> 00:04:16,920
+And by this offer and acceptance we will have a
+
+54
+00:04:16,920 --> 00:04:21,440
+contract. Of course, we’re going to have the
+
+55
+00:04:21,440 --> 00:04:24,080
+intention, because a contract with no intention
+
+56
+00:04:24,080 --> 00:04:26,660
+is not a contract. In some cases, in some
+
+57
+00:04:26,660 --> 00:04:31,080
+situations you have to write it down, but most
+
+58
+00:04:31,080 --> 00:04:34,040
+likely a contract can be made orally, not written down.
+
+59
+00:04:34,040 --> 00:04:38,460
+We can define a contract simply, as you can see
+
+60
+00:04:38,460 --> 00:04:42,020
+here. A contract is a legally binding exchange, legally
+
+61
+00:04:42,020 --> 00:04:46,140
+binding exchange of promises. So, I can make a
+
+62
+00:04:46,140 --> 00:04:50,640
+promise, or even here, agreement to enforce
+
+63
+00:04:50,640 --> 00:04:57,600
+something, to deliver. You can promise or you can
+
+64
+00:04:57,600 --> 00:05:00,240
+deliver; it goes for the same point. So, a contract is
+
+65
+00:05:00,240 --> 00:05:06,100
+based on offer and acceptance, by a promise and a
+
+66
+00:05:06,100 --> 00:05:08,300
+promise, delivering the goods and the items and the
+
+67
+00:05:08,300 --> 00:05:11,340
+money. In the past, in a Latin word, in a Latin
+
+68
+00:05:16,230 --> 00:05:22,830
+language, “contract” meant “bags.” Bags must be kept
+
+69
+00:05:22,830 --> 00:05:27,250
+packed; it’s… it’s a contract. At the same
+
+70
+00:05:27,250 --> 00:05:34,050
+time, it means a contract; bags must be kept. Now, if
+
+71
+00:05:34,050 --> 00:05:36,430
+you look again here, you’ll find that two people
+
+72
+00:05:36,430 --> 00:05:41,390
+signing a contract, this would result in
+
+73
+00:05:41,390 --> 00:05:45,600
+obligations. These obligations on both sides:
+
+74
+00:05:45,600 --> 00:05:51,080
+delivering the goods, getting the money; it’s
+
+75
+00:05:51,080 --> 00:05:55,540
+something called consideration; it’s the value: the
+
+76
+00:05:55,540 --> 00:05:58,460
+money I would pay and the item I would receive.
+
+77
+00:05:58,460 --> 00:06:03,400
+It’s here: A would do something and B would do
+
+78
+00:06:03,400 --> 00:06:08,440
+something, and both of them have obligations. These
+
+80
+00:06:15,030 --> 00:06:18,970
+came from the contract, from making the offer and
+
+81
+00:06:18,970 --> 00:06:21,030
+making the acceptance. These are the resulting
+
+82
+00:06:21,030 --> 00:06:25,010
+obligations: what shall I do and what shall you do?
+
+83
+00:06:25,010 --> 00:06:28,930
+And they will do something and you will do
+
+84
+00:06:28,930 --> 00:06:32,670
+something else, like
+
+85
+00:06:32,670 --> 00:06:38,130
+if paying some money, you have to pay it on time. It
+
+86
+00:06:38,130 --> 00:06:40,630
+can be by installment; it can be one payment. When
+
+87
+00:06:40,630 --> 00:06:43,610
+you buy anything, any item. عندما تريد أن تبقى مستعمر
+
+88
+00:06:43,610 --> 00:06:48,770
+يمكنك أن تدفع المال للمستعمر في وقت مناسب. عندما
+
+89
+00:06:48,770 --> 00:06:54,070
+تريد أن تشتري شرط حماية مع شركة، شركة حماية، ففي هذه
+
+90
+00:06:54,070 --> 00:06:57,150
+الحالة ستحصل على مال حماية. يمكن أن يكون من خلال
+
+91
+00:06:57,150 --> 00:07:00,810
+أقساط، أو يمكن أن يكون من خلال دفع واحد. في هذه الحالة،
+
+92
+00:07:00,810 --> 00:07:07,190
+يمكن أن ترى أن A يجب أن يفعل شيئاً و B يجب أن يفعل
+
+93
+00:07:07,190 --> 00:07:11,730
+شيئاً آخر. في حالة إذا كان واحد منهم has breached the
+
+94
+00:07:11,730 --> 00:07:18,050
+contract; they say that A breached, يخالف، A
+
+95
+00:07:18,050 --> 00:07:22,370
+has not delivered on time, or maybe the quality was
+
+96
+00:07:22,370 --> 00:07:24,810
+not good enough, maybe no specification, like
+
+97
+00:07:24,810 --> 00:07:28,530
+selling this computer to somebody; I would sell it
+
+98
+00:07:28,530 --> 00:07:31,790
+with the specifications and the quality stated in
+
+99
+00:07:31,790 --> 00:07:35,610
+the contract. If it’s not, then it means that we
+
+100
+00:07:35,610 --> 00:07:39,070
+have a breach of contract، مخالفة. One of them
+
+102
+00:07:39,560 --> 00:07:41,780
+has breached the contract, then the second party
+
+103
+00:07:41,780 --> 00:07:49,160
+would have a remedy.
+
+104
+00:07:49,160 --> 00:07:54,900
+مخالفة، remedy. It’s kind of تعويض، it’s kind of
+
+105
+00:07:54,900 --> 00:07:56,780
+compensation. But this compensation can be
+
+106
+00:07:56,780 --> 00:08:00,080
+financial compensation; it can be sometimes an
+
+107
+00:08:00,080 --> 00:08:03,560
+action. Remedies, we can have two types: we have
+
+108
+00:08:03,560 --> 00:08:07,660
+compensation, money compensation. You have to pay it; it
+
+109
+00:08:07,660 --> 00:08:13,500
+can be sometimes أفعال، وأفعال يجب أن تأخذها، لأن في
+
+110
+00:08:13,500 --> 00:08:17,920
+بعض الحالات، المال ليس جيداً كفاية. شخص ما يجب أن
+
+111
+00:08:17,920 --> 00:08:24,220
+يعمل أفعالاً، يجب أن يأخذ أفعالاً. لذا، إذا قالوا بأن B
+
+112
+00:08:24,220 --> 00:08:27,840
+A, B, A, B, A, B, A, B, A, B, A, B,
+
+113
+00:08:27,840 --> 00:08:30,600
+B, A, B, A, B, A, B, A, B, A, B, A,
+
+114
+00:08:30,600 --> 00:08:31,240
+B, A, B, A, B, A, B, A, B, A, B, A,
+
+115
+00:08:31,240 --> 00:08:32,500
+B, A, B, A, B, A, B, A, B, A, B,
+
+116
+00:08:32,500 --> 00:08:39,850
+B, A, B. عند إعادة المساعدة، بإمكاننا أن ننهي
+
+117
+00:08:39,850 --> 00:08:44,950
+المشروع. سنبحث عن كل هذه التفاصيل في وقتها، في وقتها.
+
+118
+00:08:44,950 --> 00:08:52,590
+يجب أن نرى الكثير من النقاط حول هذه الأشياء، أكثر
+
+119
+00:08:52,590 --> 00:08:55,730
+من المشاريع التي نعملها في حياتنا، أكثر منها مجتمعة
+
+120
+00:08:55,730 --> 00:08:58,870
+مجتمعة مجتمعة مجتمعة مجتمعة مجتمعة مجتمعة مجتمعة
+
+121
+00:08:58,870 --> 00:08:59,030
+مجتمعة مجتمعة مجتمعة مجتمعة مجتمعة مجتمعة مجتمعة
+
+122
+00:08:59,030 --> 00:09:04,770
+مجتمعة مجتمعة مجتمعة مجتمعة مجتمعة مجتمعة
+
+123
+00:09:04,770 --> 00:09:05,270
+مجتمعة مجتمعة مجتمعة مجتمعة مجتمعة مجتمعة مجتمعة
+
+124
+00:09:05,270 --> 00:09:07,400
+مجتمعة مجتمعة مجتمعة مجتمعة مجتمعة مجتمcontracts
+
+125
+00:09:07,400 --> 00:09:11,640
+we make, which are… which are not costing too much
+
+126
+00:09:11,640 --> 00:09:15,020
+money, like something cheap, buying something and
+
+127
+00:09:15,020 --> 00:09:18,400
+paying a little amount of money, a hundred pounds,
+
+128
+00:09:18,540 --> 00:09:21,500
+two hundred pounds, fifty dollars, things like
+
+129
+00:09:21,500 --> 00:09:23,920
+this; it’s not worthy; you don’t have to write it
+
+130
+00:09:23,920 --> 00:09:27,340
+down. If it’s something expensive, most likely you
+
+131
+00:09:27,340 --> 00:09:30,380
+would have to make it in a special format. When you
+
+132
+00:09:30,380 --> 00:09:34,060
+buy a house, land, when you buy a car, then the
+
+133
+00:09:34,060 --> 00:09:36,080
+contract would be written down on a piece of paper.
+
+134
+00:09:36,400 --> 00:09:39,300
+But when you buy a jacket, a headscarf, glasses,
+
+135
+00:09:39,720 --> 00:09:43,700
+a mobile phone, most likely you will not have a
+
+136
+00:09:43,700 --> 00:09:47,480
+contract on a piece of paper, written down. You can…
+
+137
+00:09:47,480 --> 00:09:50,800
+The contract exists once I make the offer and you
+
+138
+00:09:50,800 --> 00:09:53,420
+make the acceptance. We have the intention، في
+
+139
+00:09:53,420 --> 00:09:56,180
+النية، and we have the value, the consideration,
+
+140
+00:09:56,380 --> 00:09:59,560
+the money and the item. That’s a contract; it
+
+141
+00:09:59,560 --> 00:10:02,260
+doesn’t have to be on a piece of paper. Some
+
+142
+00:10:02,260 --> 00:10:05,440
+contracts are written down in a document, are
+
+143
+00:10:05,440 --> 00:10:11,920
+documented. Documentation هي just as evidence; we
+
+144
+00:10:11,920 --> 00:10:15,320
+use it as evidence, but in some cases you have
+
+145
+00:10:15,320 --> 00:10:18,760
+to… you have an obligation by the court or by the
+
+146
+00:10:18,760 --> 00:10:21,540
+law that some contracts have to be written down,
+
+147
+00:10:21,540 --> 00:10:26,980
+like to buy a car; it cannot be an oral contract; it
+
+148
+00:10:26,980 --> 00:10:30,020
+has to be in writing, on a piece of paper; to buy a
+
+149
+00:10:30,020 --> 00:10:33,600
+house… to buy a house. We will look at these points
+
+150
+00:10:33,600 --> 00:10:36,220
+later on. You have to write it down in a special
+
+151
+00:10:36,220 --> 00:10:39,620
+form, and it has to be signed and it has to be
+
+152
+00:10:39,620 --> 00:10:43,500
+authorized by a legal authority; otherwise, it’s not
+
+153
+00:10:43,500 --> 00:10:47,200
+a contract; I mean, it’s not valid. It’s a contract,
+
+154
+00:10:47,200 --> 00:10:50,320
+but it’s not enforceable. We will look at such cases
+
+155
+00:10:50,320 --> 00:10:54,480
+later on. And in general, as I say, that ninety-nine
+
+156
+00:10:54,480 --> 00:10:57,700
+percent… I can see myself, over ninety percent or
+
+157
+00:10:57,700 --> 00:11:00,970
+ninety-five percent of contracts are oral contracts. How
+
+158
+00:11:00,970 --> 00:11:03,150
+many times have you signed a contract in your life?
+
+159
+00:11:03,150 --> 00:11:08,690
+How many times? You cannot remember; you cannot
+
+160
+00:11:08,690 --> 00:11:11,590
+remember, because you might do it once or twice,
+
+161
+00:11:11,590 --> 00:11:14,650
+four or five times in your life, you signed a
+
+162
+00:11:14,650 --> 00:11:17,750
+contract on a piece of paper, but most likely what
+
+163
+00:11:17,750 --> 00:11:22,990
+you do is something oral, one-to-one. This is a
+
+164
+00:11:22,990 --> 00:11:26,810
+contract. So, it’s a legally binding exchange, exchange
+
+165
+00:11:26,810 --> 00:11:31,110
+of A and B promises, offer and acceptance, offer and
+
+166
+00:11:31,110 --> 00:11:35,650
+acceptance, exchange of goods and money, or it can be
+
+167
+00:11:35,650 --> 00:11:38,590
+sometimes goods and goods, item and item, exchange
+
+168
+00:11:38,590 --> 00:11:44,670
+items, services. It’s something else called quasi-
+
+169
+00:11:44,670 --> 00:11:49,570
+contract. This is not a contract; in fact, it’s a
+
+170
+00:11:49,570 --> 00:11:52,630
+quasi-contract; it’s something that looks like a
+
+171
+00:11:52,630 --> 00:11:57,470
+contract, but it’s not. We assume to have a contract,
+
+172
+00:11:57,470 --> 00:12:01,810
+but in fact there is no contract. Assuming this, like
+
+173
+00:12:01,810 --> 00:12:06,070
+if you remember last time we spoke about agency by
+
+174
+00:12:06,070 --> 00:12:09,270
+estoppel, agency by estoppel. We said that we have a
+
+175
+00:12:09,270 --> 00:12:13,710
+de facto situation, which we have to assume that we
+
+176
+00:12:13,710 --> 00:12:17,530
+had an agency, but in fact there is no agency. It’s
+
+177
+00:12:17,530 --> 00:12:22,110
+the same case. In fact, here there is no contract in a
+
+178
+00:12:22,110 --> 00:12:25,990
+quasi-contract, but we assume by law that we
+
+179
+00:12:25,990 --> 00:12:29,970
+have a contract. وهذا يُحمّل من الحكومة، من
+
+180
+00:12:29,970 --> 00:12:35,910
+القضاء. انظر، في المعاملة، لدينا إعطاء وإقبال، لدينا
+
+181
+00:12:35,910 --> 00:12:37,530
+إعطاء وإقبال، لدينا إعطاء وإقبال، لدينا إعطاء و
+
+182
+00:12:37,530 --> 00:12:41,110
+إقبال، لدينا إعطاء وإقبال، لدينا
+
+183
+00:12:41,110 --> 00:12:42,350
+إعطاء وإقبال، لدينا إعطاء وإقبال، لدينا إعطاء و
+
+184
+00:12:42,350 --> 00:12:44,430
+إقبال، لدينا إعطاء وإقبال، لدينا إعطاء و إقبال
+
+185
+00:12:44,430 --> 00:12:51,370
+لدينا إعطاء وإقبال، لدينا إعطاء وإقبال، لدينا
+
+186
+00:12:51,370 --> 00:12:55,250
+إعطاء وإقبال، لدينا إعطاء وإقبال، لدينا إعطاء و
+
+187
+0
+
+223
+00:15:43,910 --> 00:15:47,350
+سيقوم بإطلاق القرار، يفرض فرد على الشركة الثانوية
+
+224
+00:15:47,350 --> 00:15:51,410
+بإطلاقه، والشركة الثانوية يجب أن تقبله باستخدام
+
+225
+00:15:51,410 --> 00:16:00,070
+الحكومة تقول A يصنع المعرض، ولكن B ينفع، لا ينفع
+
+226
+00:16:00,070 --> 00:16:03,740
+يريد he doesn't want to deliver, then the judge
+
+227
+00:16:03,740 --> 00:16:07,740
+would enforce. B would impose on him an obligation.
+
+228
+00:16:07,740 --> 00:16:11,940
+you have to, you have no options, why? Because we
+
+229
+00:16:11,940 --> 00:16:15,060
+would like to avoid injustice, because the second
+
+230
+00:16:15,060 --> 00:16:18,460
+party, if the second party does not accept this
+
+231
+00:16:18,460 --> 00:16:21,720
+obligation, we would have a situation of injustice.
+
+232
+00:16:21,720 --> 00:16:27,480
+what does it mean injustice? ظلم، which can be on
+
+233
+00:16:27,480 --> 00:16:32,710
+one party. لإيقاف المخلوقات، لإيقاف المخلوقات يجب أن
+
+234
+00:16:32,710 --> 00:16:38,230
+نقوم بإيقاف مواجهة على الجانب الثاني، وهذه المواجهة
+
+235
+00:16:38,230 --> 00:16:44,630
+تأتي من فعالية مجنونة، أو فقط فعالية من رجل، شخص
+
+236
+00:16:44,630 --> 00:16:46,870
+ما يفعل فعالية؟ أنا أستطيع فعل فعالية، ويمكنك
+
+237
+00:16:46,870 --> 00:16:52,770
+الحصول على فعالية مفيدة بسيطة، مثل هذه، تعمل عملية
+
+238
+00:16:52,770 --> 00:16:55,370
+واحدة واحدة واحدة واحدة واحدة واحدة واحدة واحدة
+
+239
+00:16:55,370 --> 00:16:58,890
+واحدة واحدة واحدة واحدة واحدة واحدة واحدة واحدة
+
+240
+00:16:58,890 --> 00:17:04,570
+واحدة واحدة واحدة واحدة واحدة واحدة واحدة واحدة
+
+241
+00:17:04,570 --> 00:17:04,850
+واحدة واحدة واحدة واحدة واحدة واحدة واحدة واحدة
+
+242
+00:17:04,850 --> 00:17:08,670
+واحدة واحدة واحدة واحدة واحدة واحدة واحدة واحدة
+
+243
+00:17:08,670 --> 00:17:09,230
+واحدة واحدة واحدة واحدة واحدة واحدة واحدة واحدة
+
+244
+00:17:09,230 --> 00:17:09,610
+واحدة واحدة واحدة واحدة واحدة واحدة واحدة واحدة
+
+245
+00:17:09,610 --> 00:17:18,790
+واحدة واحدة واحدة واحدة واحدة واحدة واحدة
+
+246
+00:17:18,790 --> 00:17:24,510
+واحدة واحد. In accordance to the amount of the value
+
+247
+00:17:24,510 --> 00:17:29,850
+of benefit you had. Now we will have the example to
+
+248
+00:17:29,850 --> 00:17:31,870
+explain it more. It will be easy for you once we
+
+249
+00:17:31,870 --> 00:17:34,510
+have the example. But before that we look at this
+
+250
+00:17:34,510 --> 00:17:39,950
+here. Look, consent again. First example we had in
+
+251
+00:17:39,950 --> 00:17:42,270
+contract, we have consent.
+
+252
+00:17:49,830 --> 00:17:53,470
+consent. Two of them makes the consent. Both of them
+
+253
+00:17:53,470 --> 00:17:56,270
+accepts the contract. When it was a contract, there
+
+254
+00:17:56,270 --> 00:17:59,710
+is no need, I'm not waiting for you to make a
+
+255
+00:17:59,710 --> 00:18:02,290
+consent or to accept, though I can go to judge. I
+
+256
+00:18:02,290 --> 00:18:05,250
+can go to court and they will impose an obligation
+
+257
+00:18:05,250 --> 00:18:08,430
+on you. Someone would say, well come on, is it going
+
+258
+00:18:08,430 --> 00:18:12,050
+to be easy like this? Why someone can force me to
+
+259
+00:18:12,050 --> 00:18:15,550
+pay? Can I? I have the will, the free will. I have the
+
+260
+00:18:15,550 --> 00:18:18,450
+freedom, I have the choice. Can anyone impose on me
+
+261
+00:18:18,450 --> 00:18:23,340
+an obligation? Usually it's not, normally no one can
+
+262
+00:18:23,340 --> 00:18:26,340
+impose any obligation on me. I have the freedom to
+
+263
+00:18:26,340 --> 00:18:29,820
+take my decision at any time I would like to take
+
+264
+00:18:29,820 --> 00:18:34,800
+it, but some situations I would have to pay for
+
+265
+00:18:34,800 --> 00:18:44,380
+something because of my mistake, or because of my
+
+266
+00:18:44,380 --> 00:18:49,540
+achieving benefit from someone else. I get some
+
+267
+00:18:49,540 --> 00:18:53,010
+benefit from you. لين I would have to pay for that
+
+268
+00:18:53,010 --> 00:18:55,910
+benefit. Why should I take your money? Why should I
+
+269
+00:18:55,910 --> 00:18:58,870
+get your efforts and your equipment? I should pay
+
+270
+00:18:58,870 --> 00:19:03,470
+for this. I would have the example now. No consent
+
+271
+00:19:03,470 --> 00:19:07,550
+is required. We
+
+272
+00:19:07,550 --> 00:19:11,550
+have an example: a plumber. You know what is plumber?
+
+273
+00:19:11,550 --> 00:19:18,290
+... plumber. السباك ... plumber accidentally installs
+
+274
+00:19:18,290 --> 00:19:23,210
+a sprinkler system. Sprinkler. طبعا شاشات الميه، شوفته
+
+275
+00:19:23,210 --> 00:19:25,790
+في ملعب الجامعة. In the lawn of the university
+
+276
+00:19:25,790 --> 00:19:31,190
+يسودو. Sprinkler water sprinkler system in the lawn
+
+277
+00:19:31,190 --> 00:19:36,510
+of the wrong house. Someone
+
+278
+00:19:36,510 --> 00:19:40,450
+comes to your place installing a sprinkler system
+
+279
+00:19:40,450 --> 00:19:45,010
+when you're not at the place. You ... now you go
+
+280
+00:19:45,010 --> 00:19:49,210
+back home. When you go back home you find the fence
+
+281
+00:19:49,210 --> 00:19:51,770
+of your garden ... the fence of your garden was
+
+282
+00:19:51,770 --> 00:19:57,550
+fixed, or maybe the wall of your house was built.
+
+283
+00:19:57,550 --> 00:20:01,550
+Someone came and built the wall in your house
+
+284
+00:20:01,550 --> 00:20:06,670
+after a storm ... after a storm in the area, some of
+
+285
+00:20:06,670 --> 00:20:11,390
+the walls of the houses falling down. A builder
+
+286
+00:20:11,390 --> 00:20:16,240
+came and he built ... he built. هو قام بإصلاح قمة
+
+287
+00:20:16,240 --> 00:20:23,620
+المنزل، أو قمة المنزل، وذهب للمنزل ورأى أن قمة
+
+288
+00:20:23,620 --> 00:20:27,060
+المنزل ممتازة، وقمة المنزل ممتازة، هل ستدفعين لذلك
+
+289
+00:20:27,060 --> 00:20:29,180
+أم لا؟
+
+290
+00:20:49,430 --> 00:20:53,590
+Okay, good. Anyone else? Anyone would like to explain
+
+291
+00:20:53,590 --> 00:20:57,050
+it more? We have many examples like this. It's not
+
+292
+00:20:57,050 --> 00:20:59,930
+only about the fence or the wall, sprinkler. Some
+
+293
+00:20:59,930 --> 00:21:03,330
+people get post by mistake. You can get some items
+
+294
+00:21:03,330 --> 00:21:06,790
+in the post. In Gaza we don't have much post here
+
+295
+00:21:06,790 --> 00:21:10,370
+because the postal system, it's not effective in
+
+296
+00:21:10,370 --> 00:21:12,590
+many places like UK or France or different
+
+297
+00:21:12,590 --> 00:21:17,230
+countries. In many abusive places that people have
+
+298
+00:21:17,230 --> 00:21:21,430
+items delivered to their places. Like I can buy a
+
+299
+00:21:21,430 --> 00:21:24,950
+laptop or mobile phone, watch, glasses, and this
+
+300
+00:21:24,950 --> 00:21:28,870
+can be delivered to my place by postman, by the
+
+301
+00:21:28,870 --> 00:21:33,780
+postman, by delivery. And you know that in many
+
+302
+00:21:33,780 --> 00:21:37,000
+places, that especially in UK for example, or
+
+303
+00:21:37,000 --> 00:21:39,980
+European countries, houses they look the same, the
+
+304
+00:21:39,980 --> 00:21:42,040
+same street. When you walk they look the same. You
+
+305
+00:21:42,040 --> 00:21:44,940
+can know by number. By mistake sometimes you can
+
+306
+00:21:44,940 --> 00:21:48,580
+receive some items do not belong to you, and it
+
+307
+00:21:48,580 --> 00:21:53,520
+happens in many cases. Someone can deliver an item,
+
+308
+00:21:53,520 --> 00:21:57,920
+laptop, computer, something was delivered, an item
+
+309
+00:21:57,920 --> 00:22:01,070
+electronic item was delivered to your house, and it
+
+310
+00:22:01,070 --> 00:22:04,210
+just opened and used it. Will you pay for this or
+
+311
+00:22:04,210 --> 00:22:19,610
+not? What do you think now?
+
+312
+00:22:19,610 --> 00:22:25,110
+If something is not mine, I should not use it. If
+
+313
+00:22:25,110 --> 00:22:27,190
+something is not mine, I should not take it from
+
+314
+00:22:27,190 --> 00:22:29,850
+the beginning, and if I use it, I would have to pay
+
+315
+00:22:29,850 --> 00:22:33,780
+for that, because I have the benefit of this item, of
+
+316
+00:22:33,780 --> 00:22:37,100
+this commodity. If someone made me a favor, it's not
+
+317
+00:22:37,100 --> 00:22:41,320
+a favor, it's a benefit for me, then I would have to
+
+318
+00:22:41,320 --> 00:22:44,600
+pay for this. You see, imagine yourself living in a
+
+319
+00:22:44,600 --> 00:22:48,280
+building, five floors, and each floor you have two
+
+320
+00:22:48,280 --> 00:22:54,660
+flats, two flats. And one day you came back home
+
+321
+00:22:54,660 --> 00:22:58,560
+after working, and he found somebody cleaned the
+
+322
+00:22:58,560 --> 00:23:00,540
+windows of your flat, the whole windows from
+
+323
+00:23:00,540 --> 00:23:04,900
+outside. Are you gonna pay for that person or not؟
+
+324
+00:23:04,900 --> 00:23:09,020
+Why not؟ By mistake that person supposed to clean
+
+325
+00:23:09,020 --> 00:23:12,640
+the windows of next door flat for your neighbor,
+
+326
+00:23:12,640 --> 00:23:15,680
+but he or she came to your flat cleaning the
+
+327
+00:23:15,680 --> 00:23:21,020
+windows from outside. Will you pay for this؟ It's
+
+328
+00:23:21,020 --> 00:23:26,230
+not your business؟ It can be yes, it can be no. It's
+
+329
+00:23:26,230 --> 00:23:31,390
+most likely can be no, if what ... no, if I don't
+
+330
+00:23:31,390 --> 00:23:35,970
+know about him. If I have no idea, I was not there, I
+
+331
+00:23:35,970 --> 00:23:38,930
+didn't know about him. I mean, even the man cleaned
+
+332
+00:23:38,930 --> 00:23:41,910
+him, he cannot make it dirty again. He just cleaned
+
+333
+00:23:41,910 --> 00:23:47,630
+him. غالبًا، then he cannot ... I cannot pay him.
+
+334
+00:23:47,630 --> 00:23:51,150
+It's up to me. It's a moral thing, it's an ethical
+
+335
+00:23:51,150 --> 00:23:53,110
+thing. If I would like to pay that person, I will
+
+336
+00:23:53,110 --> 00:23:57,620
+pay him, but legally no one can force me. إذا كنت
+
+337
+00:23:57,620 --> 00:24:01,160
+أعرف أن هذا هو الحالة الثانية. إذا كنت أعرف من
+
+338
+00:24:01,160 --> 00:24:05,840
+البداية ما كان يفعله، وأنا لم أرى أي شيء. إذا كنت
+
+339
+00:24:05,840 --> 00:24:10,040
+أعرف، إذا كان لدي المعرفة، فأنا لازم أعرفه في هذه
+
+340
+00:24:10,040 --> 00:24:13,760
+الحالة. أنا لازم أعرفه، لأن انظر إلى هذا، نعم يمكن أن
+
+341
+00:24:13,760 --> 00:24:19,940
+يكون. وضحك أن الرجل يعرف هذا. هو حالة مختلفة، لذلك
+
+342
+00:24:19,940 --> 00:24:22,600
+الكثير من الناس يسألون نفس السؤال. كيف يمكن أن شخص
+
+343
+00:24:22,600 --> 00:24:25,790
+يقوم بتحقيق حالة؟ هذا ليس قانون مجتمعية. This is
+
+344
+00:24:25,790 --> 00:24:31,170
+called procedural law. If you claim something, if
+
+345
+00:24:31,170 --> 00:24:33,230
+you claim anything, if you have a lawsuit in the
+
+346
+00:24:33,230 --> 00:24:36,750
+court, it's your responsibility. You have to submit
+
+347
+00:24:36,750 --> 00:24:39,250
+all necessary evidence. You can bring some
+
+348
+00:24:39,250 --> 00:24:44,190
+witnesses, you can bring documents, film. Any witness,
+
+349
+00:24:44,190 --> 00:24:48,650
+any document, it can be used, it can be used. You can
+
+350
+00:24:48,650 --> 00:24:53,250
+use it in the court. That's your job. القاضي يمكن أن
+
+351
+00:24:53,250 --> 00:24:56,510
+يَقف، في القاضي يمكن أن يقف وينظر إلى كلا الطرفين A
+
+352
+00:24:56,510 --> 00:25:01,210
+وB. ما هي الوثيقة التي لديها؟ كلا الوثيقة، والقاضي
+
+353
+00:25:01,210 --> 00:25:04,790
+سينظر إلى ضرر الوثيقة هنا، اللي يمكن أن يكون في كلا
+
+354
+00:25:04,790 --> 00:25:08,510
+الطرفين. لتخيل أي واحد منهم أكثر قوة هنا؟ ليس كذلك في
+
+355
+00:25:08,510 --> 00:25:11,770
+الحكومة، القانونية. الحكومة القانونية. الوثيقة يجب أن
+
+356
+00:25:11,770 --> 00:25:17,110
+تكون خارج اعتقاد، مفهوم. لا اعتقاد على الإطلاق، 100%
+
+357
+00:25:17,110 --> 00:25:22,890
+مستقل. الوثيقة، مفهوم. في الحكومة، السياسية، التجارية،
+
+358
+00:25:22,890 --> 00:25:26,610
+التجارية التجارية التجارية التجارية التجارية
+
+359
+00:25:26,610 --> 00:25:26,950
+التجارية التجارية التجارية التجارية التجارية
+
+360
+00:25:26,950 --> 00:25:27,130
+التجارية التجارية التجارية التجارية التجارية
+
+361
+00:25:27,130 --> 00:25:27,290
+التجارية التجارية التجارية التجارية التجارية
+
+362
+00:25:27,290 --> 00:25:30,350
+التجارية التجارية التجارية التجارية التجارية
+
+363
+00:25:30,350 --> 00:25:30,590
+التجارية التجارية التجارية التجارية التجارية
+
+364
+00:25:30,590 --> 00:25:30,630
+التجارية التجارية التجارية التجارية التجارية
+
+365
+00:25:30,630 --> 00:25:31,770
+التجارية التجارية التجارية التجارية التجارية
+
+366
+00:25:31,770 --> 00:25:36,590
+التجارية التجارية التجارية التجارية التجارية
+
+367
+00:25:36,590 --> 00:25:39,630
+التجارية
+
+368
+00:25:39,630 --> 00:25:45,110
+التجارية
+
+369
+00:25:45,110 --> 00:25:50,890
+التجار
+
+370
+00:25:50,960 --> 00:25:53,420
+to compensate or not, to pay or not. We have
+
+371
+00:25:53,420 --> 00:25:57,160
+everything, all documents were submitted. And if he
+
+372
+00:25:57,160 --> 00:26:00,820
+knew about it, then he would have to pay. He would
+
+373
+00:26:00,820 --> 00:26:04,980
+have to pay. The other question is how much money
+
+374
+00:26:04,980 --> 00:26:09,700
+he or she would pay? How much would we have to pay
+
+375
+00:26:09,700 --> 00:26:12,160
+in this case? I did not sign a contract with them
+
+376
+00:26:12,160 --> 00:26:16,630
+with that person. I did not sign, but by court I have
+
+377
+00:26:16,630 --> 00:26:19,950
+an obligation. I have to compensate you. This is
+
+378
+00:26:19,950 --> 00:26:23,730
+what we call a quasi-contract. By court you did
+
+379
+00:26:23,730 --> 00:26:27,090
+not sign a contract with me. Here A and B, they had
+
+380
+00:26:27,090 --> 00:26:30,390
+no contract, they did not have it, but A has done
+
+381
+00:26:30,390 --> 00:26:35,750
+something for B, but B has to be by court, by force.
+
+382
+00:26:35,750 --> 00:26:39,750
+So the court would make the obligation, would
+
+383
+00:26:39,750 --> 00:26:43,590
+impose the obligation. Then this is what's called a
+
+384
+00:26:43,590 --> 00:26:45,450
+quasi-contract. How much we're going to be? Because
+
+385
+00:26:45,450 --> 00:26:47,930
+we know from the beginning, if we have a contract,
+
+386
+00:26:47,930 --> 00:26:50,770
+most likely in this contract we can state exactly
+
+387
+00:26:50,770 --> 00:26:55,150
+how much money I would pay for the item, for the
+
+388
+00:26:55,150 --> 00:26:59,230
+service. But if we have a quasi-contract here, we
+
+389
+00:26:59,230 --> 00:27:01,530
+did not state from the beginning how much I would
+
+390
+00:27:01,530 --> 00:27:05,990
+pay, then how much would it be? How much would it be?
+
+391
+00:27:05,990 --> 00:27:09,070
+Easy
+
+392
+00:27:09,070 --> 00:27:12,040
+question. Come on, someone was, I was doing something
+
+393
+00:27:12,040 --> 00:27:15,320
+for you, a favor, not a favor, getting benefit for
+
+394
+00:27:15,320 --> 00:27:17,940
+you, you take an item, how much would you pay for
+
+395
+00:27:17,940 --> 00:27:22,720
+this؟ I think this one is a bit different. I think
+
+396
+00:27:22,720 --> 00:27:25,760
+the judge shot you with a shotgun or something
+
+397
+00:27:25,760 --> 00:27:29,320
+like that. Sometimes you ... the value of the
+
+398
+00:27:29,320 --> 00:27:33,140
+service or the item you use can be something that
+
+399
+00:27:33,140 --> 00:27:37,260
+the number of people that pay you. Yes. Because you
+
+400
+00:27:37,260 --> 00:27:41,470
+are part of the economy. Why should you have a
+
+401
+00:27:41,470 --> 00:27:45,250
+discount؟ Well, it's not ... this is not the case ...
+
+402
+00:27:45,250 --> 00:27:47,690
+the case that we have a quasi-contract ... a
+
+403
+00:27:47,690 --> 00:27:50,450
+quasi-contract, legally have the same obligation
+
+404
+00:27:50,450 --> 00:27:54,010
+like a contract ... obligations are the same ... you
+
+405
+00:27:54,010 --> 00:27:56,110
+would have to pay ... but how much you gonna pay ...
+
+406
+00:27:56,110 --> 00:27:59,750
+it's not up to you ... you have to pay fair market
+
+407
+00:27:59,750 --> 00:28:05,170
+value ... fair market value ... سعر السوق ... how
+
+408
+00:28:05,170 --> 00:28:07,910
+much it costs on the market ... how much would it
+
+445
+00:30:36,690 --> 00:30:40,930
+then I will explain it to you هل أقابل تجارب
+
+446
+00:30:40,930 --> 00:30:48,150
+تاكتفان أو تجارب نهارات وخمس تاكتفان في المنطقة
+
+447
+00:30:48,150 --> 00:30:53,270
+أو في كورسا كورسا وكورسا وكورسا وكورسا وكورسا
+
+448
+00:30:53,270 --> 00:30:53,410
+وكورسا وكورسا وكورسا وكورسا وكورسا و
+
+449
+00:30:53,410 --> 00:30:56,130
+كورسا وكورسا وكورسا وكورسا وكورسا وكورسا و
+
+450
+00:30:56,130 --> 00:30:58,210
+كورسا وكورسا وكورسا وكورسا وكورسا وكورسا و
+
+451
+00:30:58,210 --> 00:31:07,010
+كورسا وكورسا وكورسا وكورسا وكورسا وكورسا و
+
+452
+00:31:07,010 --> 00:31:11,680
+كورلأ الـ tax it's income tax we don't know how
+
+453
+00:31:11,680 --> 00:31:17,560
+much exactly it can be 10 9 11 12 8000 pounds it
+
+454
+00:31:17,560 --> 00:31:19,880
+depends on how much work or how much income we
+
+455
+00:31:19,880 --> 00:31:23,240
+have how much income we have but most likely my
+
+456
+00:31:23,240 --> 00:31:28,020
+company paying tax on annual basis about 10000
+
+457
+00:31:28,020 --> 00:31:36,420
+pounds 2009 I paid 13000 pounds أنا had a feeling
+
+458
+00:31:37,150 --> 00:31:41,030
+the tax was too much I should not pay that amount
+
+459
+00:31:41,030 --> 00:31:44,450
+of money because this year we had income less than
+
+460
+00:31:44,450 --> 00:31:48,830
+last year which we paid tax ten thousand pounds
+
+461
+00:31:48,830 --> 00:31:55,270
+then I hired somebody which is called Anouk she is
+
+462
+00:31:55,270 --> 00:31:58,270
+a good accountant she is a good accountant what
+
+463
+00:31:58,270 --> 00:32:01,610
+she did for my company she did only tax
+
+464
+00:32:01,610 --> 00:32:05,410
+preparation service ملف الضريبة tax preparation
+
+465
+00:32:05,410 --> 00:32:09,140
+service for one week فى أسبوع واحد فوجئت أننا يجب
+
+466
+00:32:09,140 --> 00:32:13,120
+أن ندفع فقط 9000
+
+467
+00:32:13,120 --> 00:32:18,760
+pound 9000 pound بعد أن فعلت عملها فى أسبوع واحد
+
+468
+00:32:18,760 --> 00:32:24,160
+أدركت أن شركتي هذه السنة يجب أن تدفع فقط 9000
+
+469
+00:32:24,160 --> 00:32:31,160
+pound الاختلاف هو 4000 pound
+
+470
+00:32:31,160 --> 00:32:34,280
+أستطيع أن آخذها من مكتب الضرائب أستطيع أن أرسل
+
+471
+00:32:34,280 --> 00:32:40,380
+طلباً على رفع من مكتب الضرائب وهذا الرفع من مكتب
+
+472
+00:32:40,380 --> 00:32:47,600
+الضرائب 4000 ريال كانت تقدم لها أو لي؟ لشركة
+
+473
+00:32:47,600 --> 00:32:53,240
+نفسها الآن شخص ما سيسألني كم يمكنها أن تحصل من هذا
+
+474
+00:32:53,240 --> 00:33:02,720
+المال. أؤكد لكِ أنها جعلت مني أفضل؛ إنها كانت تعمل عملها
+
+475
+00:33:02,720 --> 00:33:08,620
+وبسبب ما فعلته لنا، أنا أحصل على 4000 ريال. كم يمكنها
+
+476
+00:33:08,620 --> 00:33:17,420
+أن تأخذ من ذلك المال؟ نحن لم نرَ أي شيء، نحن لم نقل
+
+477
+00:33:17,420 --> 00:33:23,820
+في عقدنا كم سآخذ هنا نصيب؟ لماذا؟ لماذا لا
+
+478
+00:33:23,820 --> 00:33:31,180
+يمكنها أن تأخذ الـ 4000 ريال؟ لماذا لا؟ لا يمكنها
+
+479
+00:33:52,180 --> 00:33:57,620
+Okay, in this case we have value, subject value. I
+
+480
+00:33:57,620 --> 00:34:03,580
+got benefit four thousand pounds. الآن كم يجب أن أنا
+
+481
+00:34:03,580 --> 00:34:08,940
+أكون؟ إنها تبكي للوقت. دعنا نتخيل أنها تبكي للوقت.
+
+482
+00:34:08,940 --> 00:34:18,440
+وفي هذه الحالة كانت هناك مخطط وأنا كنت مخالفا. إحنا
+
+483
+00:34:18,440 --> 00:34:24,400
+إحنا إحنا إحنا إحنا إحنا إحنا إحنا إحنا إحنا إحنا
+
+484
+00:34:24,400 --> 00:34:24,860
+إحنا إحنا إحنا إحنا إحنا إحنا إحنا إحنا إحنا إحنا
+
+485
+00:34:24,860 --> 00:34:31,620
+إحنا إحنا إحنا
+
+486
+00:34:31,620 --> 00:34:34,420
+أشخاص مستقلون يعملون هناك أسبوعًا وأسبوعًا، كم
+
+487
+00:34:34,420 --> 00:34:40,100
+يمكنها أن تحصل على 200 أو 300 رمز أو 500 رمز أو
+
+488
+00:34:40,100 --> 00:34:45,920
+شيئًا مثل هذا. أنا لا يجب أن أدفع لها هذا المال كله. تخيل
+
+489
+00:34:45,920 --> 00:34:51,680
+إن كان لدينا حالة مختلفة ووجدت أن كل شيء بخير ولا
+
+490
+00:34:51,680 --> 00:34:54,200
+يجب أن أحصل على أي شيء من مجلس الضرائب. هل يجب أن
+
+491
+00:34:54,200 --> 00:34:58,180
+أدفع لها أم لا؟ بعد أن جعلت الضرائب
+
+492
+00:35:01,580 --> 00:35:05,400
+عرفت أن كل شيء كان ممتازًا ولا يمكننا أن نأخذ أي
+
+493
+00:35:05,400 --> 00:35:09,280
+شيء من مجلس الضرائب. هل أستطيع أن أبقى هنا؟ بالطبع
+
+494
+00:35:09,280 --> 00:35:13,520
+أني يجب أن أبقى هنا لأنها فعلت عملًا لي، وحتى لو لم
+
+495
+00:35:13,520 --> 00:35:25,520
+أحصل على أجر فسأبقى هنا. سأكون منظمًا هنا في هذه
+
+496
+00:35:25,520 --> 00:35:29,220
+الصفحة. الآن نستطيع أن نتحرك إلى التصميم التجاري.
+
+497
+00:35:32,800 --> 00:35:36,400
+how can we form a contract? how many conditions do
+
+498
+00:35:36,400 --> 00:35:40,140
+we need? how can we sign it? how can we make it? how
+
+499
+00:35:40,140 --> 00:35:43,560
+can we end the contract? how this contract can be
+
+500
+00:35:43,560 --> 00:35:46,620
+affected legally? first of all we have to look at
+
+501
+00:35:46,620 --> 00:35:49,740
+the conditions. how many conditions? how many
+
+502
+00:35:49,740 --> 00:35:52,400
+elements you have to have in a contract to be
+
+503
+00:35:52,400 --> 00:35:58,100
+valid? to make a contract we have to have offer and
+
+504
+00:35:58,100 --> 00:36:01,850
+acceptance. condition number one is offer and
+
+505
+00:36:01,850 --> 00:36:06,990
+acceptance. condition number two is intention.
+
+506
+00:36:06,990 --> 00:36:12,450
+condition number three is consideration, which we
+
+507
+00:36:12,450 --> 00:36:16,570
+call it sometimes value, the money or the item.
+
+508
+00:36:16,570 --> 00:36:22,990
+number four, in some cases only, in some cases we
+
+509
+00:36:22,990 --> 00:36:26,150
+have to have a special, special form, but we have
+
+510
+00:36:26,150 --> 00:36:31,380
+three conditions: offer and acceptance, intention and
+
+511
+00:36:31,380 --> 00:36:35,100
+consideration. but in very few cases, very few cases
+
+512
+00:36:35,100 --> 00:36:39,860
+we can have an additional point, additional condition
+
+513
+00:36:39,860 --> 00:36:43,960
+which is called formalities, in which we have to
+
+514
+00:36:43,960 --> 00:36:47,380
+write the contract in a special form, special form.
+
+515
+00:36:47,380 --> 00:36:52,040
+one of the famous cases, one of the famous cases in
+
+516
+00:36:52,040 --> 00:36:57,580
+commercial law was company.
+
+517
+00:36:58,810 --> 00:37:06,070
+كما تشاهد هنا، أدرجتُ مقالة، وهذه المقالة كانت
+
+518
+00:37:06,070 --> 00:37:12,590
+للإنفلونزا، الفلوس. هذه المقالة كانت مثل صفر صغير،
+
+519
+00:37:12,590 --> 00:37:22,210
+صفر صفر صفر صفر صفر صفر صفر صفر صفر صفر صفر صفر
+
+520
+00:37:22,210 --> 00:37:23,090
+صفر صفر صفر صفر صفر صفر صفر صفر صفر صفر صفر
+
+521
+00:37:23,090 --> 00:37:25,870
+صفر صفر صفر صفر صفر صفر صفر صفر صفر صفر صفر
+
+522
+00:37:25,870 --> 00:37:25,990
+صفر صفر صفر صفر صفر صفر صفر صفر صفر صفر صفر
+
+523
+00:37:25,990 --> 00:37:29,340
+صفر صفر صفر صفر صفر صفر صفر صفر صفر في السنة
+
+524
+00:37:29,340 --> 00:37:33,120
+التاسعة في إنكلترا، شركة أمريكية أعلنت عن دواء
+
+525
+00:37:33,120 --> 00:37:35,820
+جديد، وهذه الأدوية الجديدة كانت أدوية حرارية
+
+526
+00:37:35,820 --> 00:37:40,440
+تعالج
+
+527
+00:37:40,440 --> 00:37:45,020
+الناس من الإنفلونزا، وإذا لم تفعل هذا فيمكنك الحصول
+
+528
+00:37:45,020 --> 00:37:51,000
+على 100 دولار. الشركة أعلنت، كما ترى هنا، هذا هو
+
+529
+00:37:51,000 --> 00:37:59,610
+المعلومة. يقول في العقد أنه حوالي 150 سنة أو أكثر. It
+
+530
+00:37:59,610 --> 00:38:04,870
+says that one hundred pound reward if this
+
+531
+00:38:04,870 --> 00:38:08,490
+medicine does not cure the patients, then you can
+
+532
+00:38:08,490 --> 00:38:13,790
+get a hundred pound reward, and hundred pound was
+
+533
+00:38:13,790 --> 00:38:16,710
+too much money. Like, hundred pound today is nothing,
+
+534
+00:38:16,710 --> 00:38:21,350
+it's not much money. Hundred pound, I don't know how
+
+535
+00:38:21,350 --> 00:38:25,430
+much it can be in a hundred fifty years ago. Maybe a
+
+536
+00:38:25,430 --> 00:38:29,640
+hell of money. Yeah, it's worth it. It's worth it. الآن
+
+537
+00:38:29,640 --> 00:38:32,460
+بعد عدة أسابيع، كانت الشركة كانت تحصل على الكثير من
+
+538
+00:38:32,460 --> 00:38:35,300
+الاشتكاءات من المستخدمين، من المستخدمين، من
+
+539
+00:38:35,300 --> 00:38:35,680
+المستخدمين، من المستخدمين، من المستخدمين، من
+
+540
+00:38:35,680 --> 00:38:35,860
+المستخدمين، من المستخدمين، من المستخدمين، من
+
+541
+00:38:35,860 --> 00:38:36,260
+المستخدمين، من المستخدمين، من المستخدمين، من
+
+542
+00:38:36,260 --> 00:38:37,000
+المستخدمين، من المستخدمين، من المستخدمين، من
+
+543
+00:38:37,000 --> 00:38:37,540
+المستخدمين، من المستخدمين، من المستخدمين، من
+
+544
+00:38:37,540 --> 00:38:40,300
+المستخدمين، من المستخدمين، من المستخدمين، من
+
+545
+00:38:40,300 --> 00:38:43,500
+المستخدمين، من المستخدمين، من المستخدمين، من
+
+546
+00:38:43,500 --> 00:38:46,140
+المستخدمين، من المستخدمين، من المستخدمين، من
+
+547
+00:38:46,140 --> 00:38:46,900
+المستخدمين، من المستخدمين، من المستخدمين، من
+
+548
+00:38:46,900 --> 00:38:49,780
+المستخدمين، من المستخدمين، من المستخدمين، من الـ
+
+549
+00:38:56,490 --> 00:39:00,430
+مش فاهم. إن أزمة ثانية موجودة في مدينة ثانية، أيها و بس
+
+550
+00:39:00,430 --> 00:39:06,930
+واحدة من هذه المدينة كانت موجودة في مدينة ثانية أيها
+
+551
+00:39:06,930 --> 00:39:09,990
+ثانية أيها و بس واحدة من هذه المدينة كانت موجودة في
+
+552
+00:39:09,990 --> 00:39:11,950
+مدينة ثانية أيها و بس واحدة من هذه المدينة كانت
+
+553
+00:39:11,950 --> 00:39:16,150
+موجودة في مدينة ثانية أيها و بس واحدة من هذه المدينة
+
+554
+00:39:16,150 --> 00:39:20,710
+كانت موجودة في مدينة ثانية أيها و بس واحدة من هذه
+
+555
+00:39:20,710 --> 00:39:23,810
+المدينة كانت موجودة في مدينة ثانية أيها و بس واحدة
+
+556
+00:39:23,810 --> 00:39:28,150
+من هذه المدينة كانت موجودة في مدينة. Good. Anyone
+
+557
+00:39:28,150 --> 00:39:31,110
+else? What do you think? Will you pay now? The
+
+558
+00:39:31,110 --> 00:39:34,230
+company refused to pay. Said, well they're not going
+
+559
+00:39:34,230 --> 00:39:38,810
+to pay that. No.
+
+560
+00:39:38,810 --> 00:39:41,230
+The patients have the proof that they used the
+
+561
+00:39:41,230 --> 00:39:48,390
+medicine, but the medicine was not effective. Yes.
+
+562
+00:39:48,390 --> 00:39:52,210
+Now they, they complained. They went to the company.
+
+563
+00:39:52,210 --> 00:39:55,350
+Refused to give them money reward. They went to the
+
+564
+00:39:55,350 --> 00:39:58,930
+court, and then the appeal up to the high court. In
+
+565
+00:39:58,930 --> 00:40:04,310
+the high court, as you can see here, in the high
+
+566
+00:40:04,310 --> 00:40:08,730
+court, in
+
+567
+00:40:08,730 --> 00:40:13,570
+the high court, it would, court of appeal, tell that
+
+568
+00:40:13,570 --> 00:40:16,670
+it would appear, it would appear to a reasonable
+
+569
+00:40:16,670 --> 00:40:20,760
+person that we have a contract. Anyone can see a
+
+570
+00:40:20,760 --> 00:40:24,100
+reasonable person، شخص معقول، can see that we have a
+
+571
+00:40:24,100 --> 00:40:26,620
+contract. Where is okay, where is the contract? Where
+
+572
+00:40:26,620 --> 00:40:30,980
+is the offer? The advertisement was an offer. Yes.
+
+573
+00:40:30,980 --> 00:40:35,720
+And using the medicine by the patient, that was the
+
+574
+00:40:35,720 --> 00:40:40,200
+acceptance. Okay, where is the intention? The
+
+575
+00:40:40,200 --> 00:40:43,760
+intention? The company said that we did not intend
+
+576
+00:40:43,760 --> 00:40:47,950
+it. Just was kind of a joke. Just advertised, just to
+
+577
+00:40:47,950 --> 00:40:51,330
+attract the customers. Now the court of appeal said,
+
+578
+00:40:51,330 --> 00:40:56,070
+well this was a serious offer. It means there was
+
+579
+00:40:56,070 --> 00:40:59,770
+an intention behind it. So the intention, see the
+
+580
+00:40:59,770 --> 00:41:01,750
+court would look at the intention. Did you intend
+
+581
+00:41:01,750 --> 00:41:06,170
+or not? Did you sign this contract under threat
+
+582
+00:41:06,170 --> 00:41:09,770
+because you were scared, or did you sign this
+
+583
+00:41:09,770 --> 00:41:12,550
+contract because you wanted to sign it? As one of
+
+584
+00:41:12,550 --> 00:41:14,690
+the conditions of the contract is the intention.
+
+585
+00:41:14,690 --> 00:41:19,480
+It's important thing. إذا أردت شخصًا ما يقول له إنه لم
+
+586
+00:41:19,480 --> 00:41:21,800
+يقم باشتراك التطبيق وإنه قام باشتراكه، فلا يوجد
+
+587
+00:41:21,800 --> 00:41:26,340
+تطبيق، لأنه لا يوجد اهتمام. في هذه الحالة نبحث عن
+
+588
+00:41:26,340 --> 00:41:31,180
+الاهتمام ونستخدم الأساس للاهتمام. الشركة جعلت
+
+589
+00:41:31,180 --> 00:41:35,760
+اهتمامًا، الشركة جعلت اهتمامًا، الشركة جعلت اهتمامًا،
+
+590
+00:41:35,760 --> 00:41:40,740
+الشركة. والشركة يجب أن تدفع لهذا. الشرطة تجعل الشركة
+
+591
+00:41:40,740 --> 00:41:42,520
+تدفع. اهتمام الشركة.
+
+592
+00:41:47,120 --> 00:41:48,860
+Well, that's a different... this... this is
+
+593
+00:41:48,860 --> 00:41:53,340
+something else... this... we have today many
+
+594
+00:41:53,340 --> 00:41:55,720
+companies advertising many items in the market...
+
+595
+00:41:55,720 --> 00:41:58,760
+you can look at TV... see many channels only
+
+596
+00:41:58,760 --> 00:42:01,920
+advertising things... items... commodities... when
+
+597
+00:42:01,920 --> 00:42:05,020
+you use them you find them not effective... but
+
+598
+00:42:05,020 --> 00:42:07,640
+people don't claim... don't ask for compensation
+
+599
+00:42:07,640 --> 00:42:10,400
+...but it's your right... you can ask... you have
+
+600
+00:42:10,400 --> 00:42:13,730
+the right فى full compensation. If somebody proves
+
+601
+00:42:13,730 --> 00:42:17,930
+to you that this item is excellent, problem is that
+
+602
+00:42:17,930 --> 00:42:22,470
+they don't have credibility, they're lying in the
+
+603
+00:42:22,470 --> 00:42:27,210
+advertisement, but they do not offer
+
+604
+00:42:27,210 --> 00:42:30,600
+you anything in return. They don't say, well we gonna
+
+605
+00:42:30,600 --> 00:42:33,740
+pay you a hundred, two hundred pounds. Say, well this
+
+606
+00:42:33,740 --> 00:42:35,940
+item is excellent. It's one of the best in the
+
+607
+00:42:35,940 --> 00:42:39,160
+market. It's amazing. And then take it and use it
+
+608
+00:42:39,160 --> 00:42:42,040
+and you're gonna like it so much. And then, but
+
+609
+00:42:42,040 --> 00:42:44,800
+there's no, there's no reward. But this company made
+
+610
+00:42:44,800 --> 00:42:47,600
+a mistake, made a mistake. The mistake it made says,
+
+611
+00:42:47,600 --> 00:42:50,780
+well if the medicine is not good then we will pay
+
+612
+00:42:50,780 --> 00:42:55,240
+you one hundred pounds. يعني I bet this, it's kind
+
+613
+00:42:55,240 --> 00:42:58,740
+of a betting. يعني مقامرة، فيها betting.
+
+614
+00:43:03,000 --> 00:43:07,700
+لننظر إلى العرض الأول، العرض الأول هو إعطاء
+
+615
+00:43:07,700 --> 00:43:17,980
+إقبال، كيف يمكنك أن تعمل إعطاء إقبال؟ كم
+
+616
+00:43:17,980 --> 00:43:22,140
+مرة قمت بعمل عقد هذا الأسبوع؟ كم عقد قمت بعمله؟
+
+617
+00:43:22,140 --> 00:43:26,420
+أي واحد منكم؟ كثير، كيف تفعلونها؟
+
+618
+00:43:43,530 --> 00:43:46,330
+can be by words, most likely by words, by saying
+
+619
+00:43:46,330 --> 00:43:50,250
+something, by stating it. Can be by action, when when
+
+620
+00:43:50,250 --> 00:43:52,530
+you go to a store you would like to buy a full
+
+621
+00:43:52,530 --> 00:43:56,810
+address, and you find the address on, on the window
+
+622
+00:43:56,810 --> 00:43:59,410
+of that store and it says this cost two hundred
+
+623
+00:43:59,410 --> 00:44:02,380
+shekels. بس went to the store and you pay the money
+
+624
+00:44:02,380 --> 00:44:06,760
+and you get the address, then you have made a
+
+625
+00:44:06,760 --> 00:44:08,500
+statement, but
+
+667
+00:46:42,740 --> 00:46:48,200
+both of them can be engaged مشغولين busy in
+
+668
+00:46:48,200 --> 00:46:54,880
+conduct, like negotiations, and you know that
+
+669
+00:46:54,880 --> 00:46:57,340
+most likely we have in our society that people
+
+670
+00:46:57,340 --> 00:47:00,420
+would like to negotiate; they cannot buy something
+
+671
+00:47:00,420 --> 00:47:03,820
+from the first look; just you have to negotiate for
+
+672
+00:47:03,820 --> 00:47:06,980
+many hours, few days, looking at different stores
+
+673
+00:47:06,980 --> 00:47:10,880
+and then you decide to buy something; then this
+
+674
+00:47:10,880 --> 00:47:15,120
+process of conducting negotiations
+
+675
+00:47:15,120 --> 00:47:23,000
+manifesting your accent بعض الأحيان ليس سهل
+
+676
+00:47:23,000 --> 00:47:25,820
+أن نعرف إذا كان لدينا إعطاء أو لا، إذا كان لدينا
+
+677
+00:47:25,820 --> 00:47:31,260
+إقبال أو لا. بعض الناس تقبل، ولكنها ليست واضحة، مثلاً
+
+678
+00:47:31,260 --> 00:47:35,260
+عندما أقول لك أني سأسحب هاتفي، الهاتف هو واضح، أنت
+
+679
+00:47:35,260 --> 00:47:38,900
+تستطيع أن تفهم هذا. إذا كان لدي هاتفي، إذا
+
+680
+00:47:38,900 --> 00:47:41,920
+كان لدي سيارتي، وأنا لدي ملاحظة في سيارتي، تسمى for
+
+681
+00:47:41,920 --> 00:47:48,800
+sale. My car is for sale and it cost $10,000; it is
+
+682
+00:47:48,800 --> 00:47:53,570
+clear identification; it's a clear indication of
+
+683
+00:47:53,570 --> 00:47:57,850
+an offer. But in some cases we cannot
+
+684
+00:47:57,850 --> 00:48:01,050
+know; it's not, we cannot know; we have some dispute
+
+685
+00:48:01,050 --> 00:48:05,390
+between two people: did we have an offer,
+
+686
+00:48:05,390 --> 00:48:08,390
+acceptance or not? If we have a dispute, what can we
+
+687
+00:48:08,390 --> 00:48:13,630
+do? You understand? No dispute in which we cannot
+
+688
+00:48:13,630 --> 00:48:17,570
+know exactly. Like I have my laptop, وأنا لدي 50
+
+689
+00:48:17,570 --> 00:48:22,630
+طالبًا، ولأنها بسيطة، وكل واحد يريد أن يشتريها، كل
+
+690
+00:48:22,630 --> 00:48:26,290
+واحد يريد أن يشتريها. أنا لدي كتاب، وهو الكتاب
+
+691
+00:48:26,290 --> 00:48:29,970
+الأخير، الكتاب الأخير، وأنا لدي 20 شخصًا، وكل واحد
+
+692
+00:48:29,970 --> 00:48:34,350
+يريد أن يشتريه. الواحد اللي يصنع الأولى عرضه، يستطيع
+
+693
+00:48:34,350 --> 00:48:37,950
+أن يشتريه، أليس كذلك؟ نعم، الواحد اللي يصنع الأولى
+
+694
+00:48:37,950 --> 00:48:42,610
+إقباله، يصبح... لأنني صنعت العرض، وأي واحد منكم
+
+695
+00:48:42,610 --> 00:48:47,680
+اللي يصنع الأولى إقباله، ثم يستطيع أن يحصل على لابتوب أو
+
+696
+00:48:47,680 --> 00:48:51,500
+كتاب. ولكن في بعض الأحيان، يمكن للناس أن يتفاوضون
+
+697
+00:48:51,500 --> 00:48:56,320
+لأنني لست مثل هذا، سأقول حسنًا، شخص آخر لاحقًا أعطى
+
+698
+00:48:56,320 --> 00:48:59,500
+لي أكثر، هو أعطى لي مئة أكثر من المال، فأنا لا
+
+699
+00:48:59,500 --> 00:49:01,380
+أستطيع أن أعطي عادة عرضي، أنا لا يجب أن أعطي عادة
+
+700
+00:49:01,380 --> 00:49:08,620
+عرضي، أنا لا أستطيع أن أعطي عادة عرضي، عرضي صحيح حتى
+
+701
+00:49:08,620 --> 00:49:12,160
+لو كان لدي مقبلة، أعني عندما تكون لدي مقبلة، قبل أن
+
+702
+00:49:12,160 --> 00:49:16,460
+أعطي عرضي، عادة عرضي. I can take back my offer
+
+703
+00:49:16,460 --> 00:49:20,440
+anytime before
+
+704
+00:49:20,440 --> 00:49:23,680
+anyone makes an acceptance. If anyone makes an
+
+705
+00:49:23,680 --> 00:49:27,560
+acceptance, then my offer is valid; we have a
+
+706
+00:49:27,560 --> 00:49:31,040
+contract. I cannot change my mind; I take back my
+
+707
+00:49:31,040 --> 00:49:35,240
+offer after somebody makes an acceptance. Then in
+
+708
+00:49:35,240 --> 00:49:37,500
+this case, some people sometimes dispute the fact
+
+709
+00:49:37,500 --> 00:49:40,420
+if we have an offer or acceptance or not. Some
+
+710
+00:49:40,420 --> 00:49:42,500
+cases, then we have to look at the reasonable
+
+711
+00:49:42,500 --> 00:49:48,070
+person. We cannot bring a judge, somebody, a mediator,
+
+712
+00:49:48,070 --> 00:49:50,890
+someone to look at this case to see, well, do we
+
+713
+00:49:50,890 --> 00:49:54,850
+have an offer, acceptance? We do not have, we don't
+
+714
+00:49:54,850 --> 00:49:58,470
+know. But most likely it's clear; you cannot bring
+
+715
+00:49:58,470 --> 00:50:01,830
+two people having their case; one of them said, well,
+
+716
+00:50:01,830 --> 00:50:04,770
+I made the acceptance, and the second said, well, I
+
+717
+00:50:04,770 --> 00:50:09,620
+did not hear him; he did not say it. I can use my
+
+718
+00:50:09,620 --> 00:50:13,500
+judgment; look at both cases, look at evidence to
+
+719
+00:50:13,500 --> 00:50:18,400
+make a reasonable person. Offer and acceptance can
+
+720
+00:50:18,400 --> 00:50:23,960
+be by words, can be written, can be oral. Offer and
+
+721
+00:50:23,960 --> 00:50:27,220
+acceptance can be sometimes only by promising; a
+
+722
+00:50:27,220 --> 00:50:32,800
+promise. If I promise to sell you my car if you
+
+723
+00:50:32,800 --> 00:50:36,900
+pass the exam, then that's a promise; it's a
+
+724
+00:50:36,900 --> 00:50:40,600
+conditional: once you pass the exam, then I can sell
+
+725
+00:50:40,600 --> 00:50:45,040
+you my car; it's a valid offer; it's an offer, but
+
+726
+00:50:45,040 --> 00:50:50,220
+it's by a promise, someone promising someone; it can
+
+727
+00:50:50,220 --> 00:50:53,760
+be sometimes by delivering. So, offer can be by many
+
+728
+00:50:53,760 --> 00:50:57,340
+ways, but can be by words, oral, written; can be by
+
+729
+00:50:57,340 --> 00:51:04,320
+conduct, like delivering, passing the item. Taking the
+
+730
+00:51:04,320 --> 00:51:08,520
+computer and give it to you; pass it to you. Can be
+
+731
+00:51:08,520 --> 00:51:11,820
+delivering it, sending it, resending it, rendering
+
+732
+00:51:11,820 --> 00:51:18,060
+it. It can be by any way. Look
+
+733
+00:51:18,060 --> 00:51:22,400
+at this slide; it's somehow important. We have
+
+734
+00:51:22,400 --> 00:51:27,140
+implied contracts. Most contracts are made clearly,
+
+735
+00:51:27,140 --> 00:51:32,660
+explicitly expressed; sometimes they are made
+
+736
+00:51:32,660 --> 00:51:38,080
+implicitly; implied. We have two types: implied in
+
+737
+00:51:38,080 --> 00:51:44,380
+fact and implied in law. How can we define implied
+
+738
+00:51:44,380 --> 00:51:50,720
+contract? Implied, implied
+
+739
+00:51:50,720 --> 00:51:54,280
+contract: something is not clear one hundred
+
+740
+00:51:54,280 --> 00:51:57,940
+percent; some of the terms, if this is the contract
+
+741
+00:51:57,940 --> 00:51:58,380
+here.
+
+742
+00:52:12,070 --> 00:52:15,530
+we have a contract and some of the terms; these are
+
+743
+00:52:15,530 --> 00:52:20,190
+terms one, two, three, four. The terms can be, can be
+
+744
+00:52:20,190 --> 00:52:24,370
+like the price, the name, the location, the quality,
+
+745
+00:52:24,370 --> 00:52:28,730
+description; all these we call them terms. بنيت في
+
+746
+00:52:28,730 --> 00:52:35,170
+العقل. Sometimes some of them can be unclear; some
+
+747
+00:52:35,170 --> 00:52:42,400
+of the terms are not expressed in words; this what
+
+748
+00:52:42,400 --> 00:52:46,080
+we call it implied contract. In general, implied
+
+749
+00:52:46,080 --> 00:52:49,620
+contract in which we have some of those terms are
+
+750
+00:52:49,620 --> 00:52:55,380
+not expressed in words; it's a full contract; it's a
+
+751
+00:52:55,380 --> 00:52:59,800
+valid contract and it's perfect, but these terms
+
+752
+00:52:59,800 --> 00:53:04,400
+are not clear. We have two ways; one of them it's
+
+753
+00:53:04,400 --> 00:53:08,500
+called implied in fact, and the second is implied
+
+754
+00:53:08,500 --> 00:53:09,040
+in law.
+
+755
+00:53:11,920 --> 00:53:16,060
+We can understand from the circumstances that we
+
+756
+00:53:16,060 --> 00:53:20,260
+have a contract, even
+
+757
+00:53:20,260 --> 00:53:25,560
+though it was not done reciprocally. I can
+
+758
+00:53:25,560 --> 00:53:28,220
+understand from the situation that I have a
+
+759
+00:53:28,220 --> 00:53:32,840
+contract, even though we did not say anything; we
+
+760
+00:53:32,840 --> 00:53:36,400
+did not express anything. Like when you go to a
+
+761
+00:53:36,400 --> 00:53:41,790
+coffee shop; will you buy coffee? I take a coffee and
+
+762
+00:53:41,790 --> 00:53:47,570
+you take a cheesecake, then you pay the money and
+
+763
+00:53:47,570 --> 00:53:52,110
+you leave; is this a contract or not? It is a
+
+764
+00:53:52,110 --> 00:53:55,570
+contract. Did you see anything? Did you discuss how
+
+765
+00:53:55,570 --> 00:53:59,370
+the contract? No; it's by action; it's implied in
+
+766
+00:53:59,370 --> 00:54:02,710
+fact. If you have a question in the exam, I don't
+
+767
+00:54:02,710 --> 00:54:06,010
+want the example; I want the meaning. The meaning is
+
+768
+00:54:06,010 --> 00:54:10,450
+I can understand from the situation, on the
+
+769
+00:54:10,450 --> 00:54:13,670
+circumstances, that we have a contract, even though
+
+770
+00:54:13,670 --> 00:54:18,270
+it was not expressed in words. Like when you go to
+
+771
+00:54:18,270 --> 00:54:21,850
+a medical doctor; when you go to a dentist to clean
+
+772
+00:54:21,850 --> 00:54:26,310
+your teeth; to clean your teeth, and then after you
+
+773
+00:54:26,310 --> 00:54:30,650
+clean the teeth, you pay the money for the service
+
+774
+00:54:30,650 --> 00:54:34,050
+and you leave; did you discuss any contract with
+
+775
+00:54:34,050 --> 00:54:38,740
+the dentist? No; you did not discuss any contract، لأن
+
+776
+00:54:38,740 --> 00:54:42,480
+this is implied in fact contract; it is a contract;
+
+777
+00:54:42,480 --> 00:54:46,560
+it does not, and did not, written; it was not, sorry, it
+
+778
+00:54:46,560 --> 00:54:49,160
+was not written down in a piece of paper; it was
+
+779
+00:54:49,160 --> 00:54:53,640
+not made in words even, but it's by conduct; it's
+
+780
+00:54:53,640 --> 00:54:57,500
+not expressed to me; it's implicitly. I can
+
+781
+00:54:57,500 --> 00:55:00,720
+understand, and you can understand that we have a
+
+782
+00:55:00,720 --> 00:55:04,600
+contract; it's implicit ضمنيًا، but in fact it's a
+
+783
+00:55:04,600 --> 00:55:10,070
+full contract. Second type: it's implied in law, which
+
+784
+00:55:10,070 --> 00:55:14,130
+is called quasi-contract; the one we just explained
+
+785
+00:55:14,130 --> 00:55:16,290
+a few minutes ago, at the beginning of this lecture,
+
+786
+00:55:16,290 --> 00:55:19,350
+and we have the example of the sprinkler system
+
+787
+00:55:19,350 --> 00:55:24,950
+and the cleaner. This is the same case: implied in
+
+788
+00:55:24,950 --> 00:55:28,750
+facts or implied in law. And quasi-contract is the
+
+789
+00:55:28,750 --> 00:55:32,350
+scheme in which the court, the judge would impose
+
+790
+00:55:32,350 --> 00:55:36,210
+an obligation on one party to avoid injustice, and
+
+791
+00:55:36,210 --> 00:55:37,170
+we have the whole example.
+
+792
+00:55:43,750 --> 00:55:46,650
+We will take the second condition, which is
+
+793
+00:55:46,650 --> 00:55:51,670
+consideration and estoppel. I
+
+794
+00:55:51,670 --> 00:55:56,350
+want you to focus mainly on consideration; leave
+
+795
+00:55:56,350 --> 00:56:01,210
+estoppel for now; leave it. Estoppel does not have
+
+796
+00:56:01,210 --> 00:56:03,970
+a specific meaning in the dictionary; you are not going
+
+797
+00:56:03,970 --> 00:56:06,850
+to find the meaning, but you will find it somewhere
+
+798
+00:56:06,850 --> 00:56:12,070
+in... when you look at the legal dictionaries; it
+
+799
+00:56:12,070 --> 00:56:17,060
+is a de facto situation in which... in which we can
+
+800
+00:56:17,060 --> 00:56:21,740
+assume... assume a case or situation, even if it
+
+801
+00:56:21,740 --> 00:56:25,440
+was not there; it's kind of a de facto situation.
+
+802
+00:56:25,440 --> 00:56:28,560
+Now,
+
+803
+00:56:28,560 --> 00:56:34,560
+consideration is the value paid for a promise. When
+
+804
+00:56:34,560 --> 00:56:36,220
+we say consideration, offer, and acceptance,
+
+805
+00:56:36,220 --> 00:56:39,320
+consideration is the value; the value, the money,
+
+806
+00:56:40,160 --> 00:56:45,470
+the item, the service; these are called
+
+807
+00:56:45,470 --> 00:56:49,490
+considerations. We have an example of this, which is
+
+808
+00:56:49,490 --> 00:56:57,510
+the car. Can you read it? Okay.
+
+809
+00:56:57,510 --> 00:57:00,670
+Speak
+
+810
+00:57:00,670 --> 00:57:01,330
+up; speak up.
+
+811
+00:57:15,770 --> 00:57:20,050
+To understand it: I have my car, and you have your
+
+812
+00:57:20,050 --> 00:57:23,130
+money. I want to sell my car, and you want to pay
+
+813
+00:57:23,130 --> 00:57:27,570
+the money. My consideration is my car, and your
+
+814
+00:57:27,570 --> 00:57:32,620
+consideration is ضمانه؛ it's the value. القيم المالية
+
+815
+00:57:32,620 --> 00:57:39,760
+والأشياء، هذه تسمى كالـتفكير، بسهولة، بسهولة الآن.
+
+816
+00:57:39,760 --> 00:57:45,220
+المال، يمكن أن يتم إعطاؤه بواسطة واحدة، بواسطة واحدة،
+
+817
+00:57:45,220 --> 00:57:46,180
+بواسطة واحدة، بواسطة واحدة، بواسطة واحدة، بواسطة
+
+818
+00:57:46,180 --> 00:57:49,200
+واحدة، بواسطة واحدة، بواسطة واحدة، بواسطة واحدة،
+
+819
+00:57:49,200 --> 00:57:49,560
+بواسطة واحدة، بواسطة واحدة، بواسطة واحدة، بواسطة
+
+820
+00:57:49,560 --> 00:57:49,680
+واحدة، بواسطة واحدة، بواسطة واحدة، بواسطة واحدة،
+
+821
+00:57:49,680 --> 00:57:51,440
+بواسطة واحدة، بواسطة واحدة، بواسطة واحدة، بواسطة
+
+822
+00:57:51,440 --> 00:57:56,040
+واحدة، بواسطة واحدة، بواسطة واحدة، بواس...
+
+823
+00:57:59,470 --> 00:58:01,730
+Consideration has to be sufficient; this is one of
+
+824
+00:58:01,730 --> 00:58:03,610
+the most difficult points in this chapter.
+
+825
+00:58:03,610 --> 00:58:07,530
+Consideration has to be sufficient; what does it
+
+826
+00:58:07,530 --> 00:58:15,110
+mean? The value has to be sufficient; will be equal
+
+827
+00:58:15,110 --> 00:58:16,130
+to the benefit.
+
+828
+00:58:19,430 --> 00:58:24,470
+Like if my car cost five thousand pounds; when I
+
+829
+00:58:24,470 --> 00:58:28,570
+sell it, I will get five thousand pounds, more or
+
+830
+00:58:28,570 --> 00:58:32,710
+less; more or less. ما exactly one hundred percent,
+
+831
+00:58:32,710 --> 00:58:35,950
+but consideration has to be sufficient; it means
+
+832
+00:58:35,950 --> 00:58:42,410
+its sufficiency here, look at this, does not mean
+
+833
+00:58:44,260 --> 00:58:48,760
+Sometimes, to have the subject value; sufficiency
+
+834
+00:58:48,760 --> 00:58:51,920
+does not mean to have a subject value in the
+
+835
+00:58:51,920 --> 00:58:54,660
+market exactly how much it cost; it can be more or
+
+836
+00:58:54,660 --> 00:58:59,120
+less. If I go to a shop to buy a mobile phone and
+
+837
+00:58:59,120 --> 00:59:02,160
+this mobile phone cost like 200 pounds and
+
+838
+00:59:02,160 --> 00:59:05,920
+everyone knows this cost 200 pounds، أنا بدي 300
+
+839
+00:59:05,920 --> 00:59:13,250
+pounds; I didn't know. هو ليس خطأي، لكني لا أعرف كثيرًا
+
+840
+00:59:13,250 --> 00:59:18,930
+عن الهاتف، الهاتف، وكم سعره، وأنا ذهبت لشخص في المتجر، و
+
+841
+00:59:18,930 --> 00:59:24,510
+لأنه يعرف أني لا أعرف، أي حدث، إذاً أنا أعرف أي حدث،
+
+842
+00:59:24,510 --> 00:59:25,070
+فأنا أعرف أي حدث، فأنا أعرف أي حدث، فأنا أعرف أي حدث،
+
+843
+00:59:25,070 --> 00:59:25,250
+فأنا أعرف أي حدث، فأنا أعرف أي حدث، فأنا أعرف أي حدث،
+
+844
+00:59:25,250 --> 00:59:25,270
+فأنا أعرف أي حدث، فأنا أعرف أي حدث، فأنا أعرف أي حدث،
+
+845
+00:59:25,270 --> 00:59:25,350
+فأنا أعرف أي حدث، فأنا أعرف أي حدث، فأنا أعرف أي حدث،
+
+846
+00:59:25,350 --> 00:59:33,590
+فأنا أعرف أي حدث، فأنا...
+
+847
+00:59:33,590 --> 00:59:37,610
+أهل يمكنني أن أعود إلى ذلك الشخص وأقول أنني أريد
+
+848
+00:59:37,610 --> 00:59:41,470
+المال مرة أخرى لأخذ هاتفه؟ لماذا لا؟ لأن التجارب
+
+849
+00:59:41,470 --> 00:59:48,330
+قد انتهت، حتى لو كانت قد انتهت، ممكن
+
+850
+00:59:48,330 --> 00:59:52,090
+أنه يستحق، وممكن أنه لا. هذه حالة مختلفة، دعنا
+
+851
+00:59:52,090 --> 00:59:56,
+
+889
+01:02:44,910 --> 01:02:48,170
+أستطيع أن أختار الفقر من المال، أنت معناه أنها
+
+890
+01:02:48,170 --> 01:02:53,770
+حقي أم لا؟ لأن هذا التقرير ليس موافقًا تمامًا، هناك
+
+891
+01:02:53,770 --> 01:02:57,790
+شيء غير صحيح. مع ذلك، لدينا لا تفكير ولا قيمة حقيقية.
+
+892
+01:02:57,790 --> 01:03:01,630
+هذا القرار، أنت تعرف أنه في القواعد الإسلامية لدينا
+
+893
+01:03:01,630 --> 01:03:05,870
+شيء مثل هذا في القواعد الإسلامية، اسمه الغبن. هل
+
+894
+01:03:05,870 --> 01:03:08,850
+سمعت عنه؟ الغبن، إذا كان لديك غبن
+
+895
+01:03:16,370 --> 01:03:22,310
+هذا يعني أن إذا عمولات المال التي تدفعها أكثر من 20
+
+896
+01:03:22,310 --> 01:03:27,170
+%، فهذا
+
+897
+01:03:27,170 --> 01:03:29,750
+العمولات ليست قادرة، يعني مسموح لك عند عشرين في
+
+898
+01:03:29,750 --> 01:03:36,290
+المئة. أنت مسموح أن تزيد عمولات المال أكثر من 20%
+
+899
+01:03:36,290 --> 01:03:41,070
+أكثر من 20% أكثر من 20% أكثر من 20% أكثر من 20%
+
+900
+01:03:41,070 --> 01:03:41,330
+أكثر من 20% أكثر من 20% أكثر من 20% أكثر من 20%
+
+901
+01:03:41,330 --> 01:03:41,490
+أكثر من 20% أكثر من 20% أكثر من 20% أكثر من 20%
+
+902
+01:03:41,490 --> 01:03:43,950
+أكثر من 20% أكثر من 20% أكثر من 20% أكثر من 20%
+
+903
+01:03:43,950 --> 01:03:49,900
+أكثر من 550... it's my... it's my right... up to a
+
+904
+01:03:49,900 --> 01:03:52,860
+limit... up to a limit... I cannot like in the
+
+905
+01:03:52,860 --> 01:03:55,660
+future if the customer comes back to me, well I...
+
+906
+01:03:55,660 --> 01:03:58,500
+it's my money and it's your computer and the
+
+907
+01:03:58,500 --> 01:04:01,040
+contract is done... but if this amount of money
+
+908
+01:04:01,040 --> 01:04:04,460
+was increased... like who can judge... who can say
+
+909
+01:04:04,460 --> 01:04:09,440
+that we have lack of consideration or not? Judge a
+
+910
+01:04:09,440 --> 01:04:13,060
+reasonable person in the market can tell if we
+
+911
+01:04:13,060 --> 01:04:18,220
+have a reasonable amount of money paid or not. If
+
+912
+01:04:18,220 --> 01:04:21,600
+we have a subject value or not. If we have a
+
+913
+01:04:21,600 --> 01:04:24,840
+consideration or we don't have a consideration in
+
+914
+01:04:24,840 --> 01:04:28,080
+this case, then as I said to you, like you know we
+
+915
+01:04:28,080 --> 01:04:32,390
+can end the contract. ولكن في بعض الأحيان لدينا
+
+916
+01:04:32,390 --> 01:04:36,330
+حركتين مختلفتين نستخدمهما لإنهاء نفس التجارب، لإنهاء
+
+917
+01:04:36,330 --> 01:04:43,450
+تجارب كهذه. تجارب ممكن تبقى غير صحيحة، لإنهاء تجارب
+
+918
+01:04:43,450 --> 01:04:45,010
+كهذه. تجارب ممكن تبقى غير صحيحة، لإنهاء تجارب كهذه
+
+919
+01:04:45,010 --> 01:04:45,610
+تجارب ممكن تبقى غير صحيحة، لإنهاء تجارب كهذه. تجارب
+
+920
+01:04:45,610 --> 01:04:50,650
+ممكن تبقى غير صحيحة، لإنهاء تجارب كهذه. تجارب ممكن
+
+921
+01:04:50,650 --> 01:04:54,270
+تبقى غير صحيحة، لإنهاء تجارب كهذه. تجارب ممكن تبقى
+
+922
+01:04:54,270 --> 01:04:59,910
+غير صحيحة، لإنهاء تجارب ممكن تبقى
+
+923
+01:05:03,220 --> 01:05:07,180
+he was cheating. He was not doing his best to sell
+
+924
+01:05:07,180 --> 01:05:09,920
+his car as it cost in the market, then I can
+
+925
+01:05:09,920 --> 01:05:13,220
+establish the basis here, the fact. I can establish
+
+926
+01:05:13,220 --> 01:05:16,260
+it on some legal basis. I can end the contract
+
+927
+01:05:16,260 --> 01:05:20,140
+because we have no legal basis, either we have lack
+
+928
+01:05:20,140 --> 01:05:22,980
+of consideration. يعني مبلغ المال ما كناش مساوي للـ
+
+929
+01:05:22,980 --> 01:05:29,940
+item. هنا لا يوجد ارتباط بين الفائدة و القيمة. لدينا
+
+930
+01:05:29,940 --> 01:05:33,400
+أيضًا ارتباط بين الفائدة والقيمة. أنا سأحصل على
+
+931
+01:05:33,400 --> 01:05:37,420
+الفائدة وهي 5 آلاف دولار. أنا سأحصل على 5 آلاف دولار
+
+932
+01:05:37,420 --> 01:05:41,720
+أكثر أو أقل. ليس كمية مال أخرى. أنا أستطيع إنهاء
+
+933
+01:05:41,720 --> 01:05:46,060
+التجربة السابقة لكي أكمل الموضوع هنا في البلدان
+
+934
+01:05:46,060 --> 01:05:50,960
+السلسلة السلسلة السلسلة السلسلة السلسلة السلسلة
+
+935
+01:05:50,960 --> 01:05:53,480
+السلسلة السلسلة السلسلة السلسلة السلسلة السلسلة
+
+936
+01:05:53,480 --> 01:05:53,800
+السلسلة السلسلة السلسلة السلسلة السلسلة السلسلة
+
+937
+01:05:53,800 --> 01:05:54,200
+السلسلة السلسلة السلسلة السلسلة السلسلة السلسلة
+
+938
+01:05:54,200 --> 01:05:56,560
+السلسلة السلسلة السلسلة. السقالة أنها كافية، لديها
+
+939
+01:05:56,560 --> 01:06:01,920
+إعطاء وإقامة واهتمام، وانتقلوا عنها وقالوا
+
+940
+01:06:01,920 --> 01:06:05,900
+أنها ليست عملنا. أنت تحصل على 10 آلاف و20 ألف، وهذا
+
+941
+01:06:05,900 --> 01:06:08,540
+مقرر معك ومعه، وهو قبل هذا وأنت قبلته من
+
+942
+01:06:08,540 --> 01:06:11,220
+البداية، ويمكنك أن تقوم باستخدامه إذا كنت تريد أن
+
+943
+01:06:11,220 --> 01:06:14,160
+تنهي مقاومتك، لأنني وجدت هذه السيارة مرعبة جدًا
+
+944
+01:06:14,160 --> 01:06:17,860
+لأجلي، اشتغلت 8 آلاف دولار وكانت فقط 3 آلاف دولار،
+
+945
+01:06:17,860 --> 01:06:22,900
+كانت خطأي. that's what it's saying, it's your mistake.
+
+946
+01:06:22,900 --> 01:06:26,980
+You can fix it. If you cannot, just leave it, keep it
+
+947
+01:06:26,980 --> 01:06:30,940
+as it is, unless you can establish a new fact that
+
+948
+01:06:30,940 --> 01:06:35,080
+that one who sold you the car wasn't cheating, he
+
+949
+01:06:35,080 --> 01:06:38,940
+was deceiving you. في غش في خداع واضح. Otherwise,
+
+950
+01:06:38,940 --> 01:06:43,800
+there is no thing called consideration. There is in
+
+951
+01:06:43,800 --> 01:06:45,560
+common law. Common law.
+
+952
+01:06:50,560 --> 01:06:55,340
+كانوا يقولون أننا يجب أن نغيّر الاعتماد بـ"استابل".
+
+953
+01:06:55,340 --> 01:06:59,900
+هذا هو الموضوع هنا. كانوا يقولون أننا يجب أن نغيّر
+
+954
+01:06:59,900 --> 01:07:02,800
+الاعتماد بـ"استابل". في الواقع، إنهم يقولون أننا لا
+
+955
+01:07:02,800 --> 01:07:07,380
+يوجد اعتماد، ولكننا لدينا إقرار ولدينا اهتمام.
+
+956
+01:07:07,380 --> 01:07:10,060
+ولكننا لدينا اهتمام. ولكننا لدينا اهتمام. ولكننا
+
+957
+01:07:10,060 --> 01:07:10,080
+لدينا اهتمام. ولكننا لدينا اهتمام. ولكننا لدينا
+
+958
+01:07:10,080 --> 01:07:10,700
+اهتمام. ولكننا لدينا اهتمام. ولكننا لدينا اهتمام.
+
+959
+01:07:10,700 --> 01:07:11,720
+ولكننا لدينا اهتمام. ولكننا لدينا اهتمام. ولكننا
+
+960
+01:07:11,720 --> 01:07:17,580
+لدينا اهتمام.  لأننا لدينا اتفاق.
+
+961
+01:07:17,580 --> 01:07:21,300
+حتى لو في الحقيقة لا يوجد اتفاق، لماذا لا يوجد
+
+962
+01:07:21,300 --> 01:07:26,760
+اتفاق؟ لأن لدينا فرقًا في التفكير المناسب. يعني، سيارة
+
+963
+01:07:26,760 --> 01:07:34,320
+المال لم يكن مرتبطًا بالفوائد. المال لم يكن مرتبطًا
+
+964
+01:07:34,320 --> 01:07:41,480
+بالفوائد. في هذه الحالة هنا، حتى لو لم نكن لدينا
+
+965
+01:07:41,480 --> 01:07:46,040
+تفكيرًا، نستطيع أن نقول أن المعاملة صحيحة لأننا
+
+966
+01:07:46,040 --> 01:07:50,000
+لدينا إقرار، ونحن لدينا اهتمام. لكن بعدها نستطيع أن
+
+967
+01:07:50,000 --> 01:07:54,320
+نقول أن هذه المعاملة ستكون مخصصة على "استابل"، إنها
+
+968
+01:07:54,320 --> 01:07:59,940
+متساومة بالمعاملة. "كوازي". إنها معاملة من "استابل"، و
+
+969
+01:07:59,940 --> 01:08:04,250
+بعدها نستطيع أن نرى إذا كان لدينا أي موقع صحيح.
+
+970
+01:08:04,250 --> 01:08:07,930
+يمكننا أن نتخلص من المعاملة أم لا. مثلاً، إذا كان
+
+971
+01:08:07,930 --> 01:08:12,030
+لدينا تخلص أو حرارة أو قوة غير متعاملة أو شيء آخر،
+
+972
+01:08:12,030 --> 01:08:16,910
+يمكننا أن نتخلص من المعاملة أم لا. يمكننا أن نتخلص
+
+973
+01:08:16,910 --> 01:08:17,150
+من المعاملة أم لا. يمكننا أن نتخلص من المعاملة أم
+
+974
+01:08:17,150 --> 01:08:17,810
+لا. يمكننا أن نتخلص من المعاملة أم لا. يمكننا أن
+
+975
+01:08:17,810 --> 01:08:19,850
+نتخلص من المعاملة أم لا. يمكننا أن نتخلص من
+
+976
+01:08:19,850 --> 01:08:22,070
+المعاملة أم لا. يمكننا أن نتخلص من المعاملة أم لا.
+
+977
+01:08:22,070 --> 01:08:23,710
+يمكننا أن نتخلص من المعاملة أم لا. يمكننا أن نتخلص
+
+978
+01:08:23,710 --> 01:08:28,610
+من المعاملة أم
+
+979
+01:08:28,610 --> 01:08:31,480
+لا. يمكننا أن... you have to look at the contract, you
+
+980
+01:08:31,480 --> 01:08:33,700
+have to look at the value and the benefit you have
+
+981
+01:08:33,700 --> 01:08:36,420
+to study what you want to buy. It's your business,
+
+982
+01:08:36,420 --> 01:08:42,640
+it's your life. This
+
+983
+01:08:42,640 --> 01:08:45,000
+is according to some legal systems in the West, they
+
+984
+01:08:45,000 --> 01:08:49,280
+say we have someone in a weak position and someone
+
+985
+01:08:49,280 --> 01:08:53,610
+in a strong position. A weak and strong bargaining
+
+986
+01:08:53,610 --> 01:08:57,150
+power. هذا المساواة... no, we have to be in equal
+
+987
+01:08:57,150 --> 01:09:00,410
+situations. Otherwise, like someone, the weak person
+
+988
+01:09:00,410 --> 01:09:08,890
+will not be able to negotiate at the same level. لا
+
+989
+01:09:08,890 --> 01:09:14,170
+يحمي... يحمي... the law will protect people. هو النظام
+
+990
+01:09:14,170 --> 01:09:16,170
+الذي يحمينا عنه. What we said before, هي الغبن.
+
+991
+01:09:18,430 --> 01:09:23,070
+ونفس الشيء الذي لدينا الآن هنا، ما يسمى بـ...
+
+992
+01:09:23,070 --> 01:09:30,530
+ما يسمى بالاعتبار. احتياط كافٍ. احتياط. احتياط. احتياط.
+
+993
+01:09:30,530 --> 01:09:36,930
+بين قيمة وفائدة. عليك أن تبني هذه الحقيقة. المعاملة
+
+994
+01:09:36,930 --> 01:09:42,550
+بين القيمة والفائدة. بين الانتصارين. بين الانتصارين.
+
+995
+01:09:42,550 --> 01:09:45,850
+شكرًا لوقتك، وسأراك يوتيوب.
diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/XsfILd61ZOg.srt b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/XsfILd61ZOg.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b024f419d17b755a97093ba472384de5ce223be8
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/XsfILd61ZOg.srt
@@ -0,0 +1,2910 @@
+
+1
+00:00:13,480 --> 00:00:19,300
+السلام عليكم before we look at the types of
+
+2
+00:00:19,300 --> 00:00:23,900
+companies, there was one slide left behind which we
+
+3
+00:00:23,900 --> 00:00:28,970
+have to discuss وهي عن بعض الأشياء التي لا يزال
+
+4
+00:00:28,970 --> 00:00:33,670
+علينا أن ننظر إليها بمعنى المساعدة كما كان لدينا
+
+5
+00:00:33,670 --> 00:00:37,630
+في السابق، الموضوع عن المساعدة المحددة والمساعدة
+
+6
+00:00:37,630 --> 00:00:42,250
+المحددة للشركات ليست للشركات، ولكن في بعض الأحيان
+
+7
+00:00:42,250 --> 00:00:45,190
+بعض الأشياء يجب أن ننظر إليها، واحدة منها هي
+
+8
+00:00:45,190 --> 00:00:50,930
+المسؤولية، المساعدة للشركة. هل تعتقد أن الشركات ستكون
+
+9
+00:00:50,930 --> 00:00:54,330
+مقابلة لأي عمل أو لأي عملية يمكنها أن تفعلها أو
+
+10
+00:00:54,330 --> 00:00:59,350
+لا؟ أعتقد نعم، لأن الشركات لها اسمها أو اسمها
+
+11
+00:00:59,350 --> 00:01:06,950
+وشخصيتها مختلفة تمامًا عن المشاركين، ولكن لدينا بعض
+
+12
+00:01:06,950 --> 00:01:09,510
+الحالات التي يجب أن ننظر إلى المسؤولية المدفوعة
+
+13
+00:01:09,510 --> 00:01:19,450
+فيها، التي يجب أن نفهم حركتها وتأثيراتها. إذا حدث شيء
+
+14
+00:01:19,450 --> 00:01:24,110
+للمستخدمين، إذا كانت أفعالهم تمت، وكانت أفعالهم غير
+
+15
+00:01:24,110 --> 00:01:30,010
+قانونية، وكانت هذه الأفعال تمت من الشركة، من يكون
+
+16
+00:01:30,010 --> 00:01:37,230
+المسؤول عنها؟ ماذا تعتقد؟ الشركة؟ المستخدمين؟ المديرين؟
+
+17
+00:01:37,230 --> 00:01:41,550
+من يأخذ المسؤولية عن هذه الأفعال؟ هذا ما نسميه
+
+18
+00:01:41,550 --> 00:01:44,690
+المسؤولية المدفوعة، المسؤولية. لا نعرف
+
+19
+00:01:44,690 --> 00:01:51,380
+بالضبط من يكون المسؤول. الشخص إذا وجدت شركة مخططة
+
+20
+00:01:51,380 --> 00:01:57,080
+لموت شخص ما، فهو سيأخذ مسؤوليته، ويعرف أن الشركات
+
+21
+00:01:57,080 --> 00:02:00,120
+والشركات لن تستطيع أن تقتل أحدهم بشكل جسدي،
+
+22
+00:02:00,120 --> 00:02:06,720
+ولكنها تستطيع أن تسبب موت شخص ما. شخص ما رحل
+
+23
+00:02:06,720 --> 00:02:12,720
+بسبب حركة حكومية، أو حركة حكومية تم صنعها الشركة، ثم
+
+24
+00:02:12,720 --> 00:02:16,100
+يجب أن ننظر إلى المسؤول. هل ستكون الشركة نفسها،
+
+25
+00:02:17,740 --> 00:02:21,940
+مؤسساتها وموظفيها من الذين يكونون مقبلين لهذه
+
+26
+00:02:21,940 --> 00:02:25,820
+الاختيارات؟ ماذا تعتقد؟ من يأخذ المسؤولية؟ قلنا
+
+27
+00:02:25,820 --> 00:02:31,260
+إننا نخسر كمؤسسات، نخسر عدد المال الذي نستخدمه، هذا
+
+28
+00:02:31,260 --> 00:02:37,220
+هو أعلى، فإن الخسارة الممكنة ستكون عدد المال الذي
+
+29
+00:02:37,220 --> 00:02:40,900
+نستخدمه، ولكن عندما يأتي إلى حالة مثل هذه، فكان
+
+30
+00:02:40,900 --> 00:02:48,520
+هناك خطأ تم فعله من جهة، وهذه الخطأ أسببت موت
+
+31
+00:02:48,520 --> 00:02:54,160
+شخص ما، أو هذه الحركة أسببت موت شخص ما، أو مستحيل
+
+32
+00:02:54,160 --> 00:02:56,600
+يكون مستحيل يكون مستحيل يكون مستحيل يكون مستحيل
+
+33
+00:02:56,600 --> 00:02:57,060
+يكون مستحيل يكون مستحيل يكون مستحيل يكون مستحيل
+
+34
+00:02:57,060 --> 00:02:57,400
+يكون مستحيل يكون مستحيل يكون مستحيل يكون مستحيل
+
+35
+00:02:57,400 --> 00:03:00,480
+يكون مستحيل يكون مستحيل يكون مستحيل مستحيل مستحيل
+
+36
+00:03:00,480 --> 00:03:07,620
+مستحيل مستحيل مستحيل مست
+
+37
+00:03:11,750 --> 00:03:16,950
+No answer. Well, as Daria said, that might be it,
+
+38
+00:03:16,950 --> 00:03:20,630
+might be the board of directors. Some scholars said
+
+39
+00:03:20,630 --> 00:03:22,810
+shareholders will have to take the responsibility
+
+40
+00:03:22,810 --> 00:03:26,310
+because they own the company, and the shareholders,
+
+41
+00:03:26,310 --> 00:03:32,410
+they run it, they manage it. Good. So if the
+
+42
+00:03:32,410 --> 00:03:35,770
+shareholders would take the responsibility, it
+
+43
+00:03:35,770 --> 00:03:39,220
+means somehow that the board of directors would
+
+44
+00:03:39,220 --> 00:03:43,260
+take their responsibility, will be liable in any
+
+45
+00:03:43,260 --> 00:03:45,540
+way. That some scholars said shareholders would be
+
+46
+00:03:45,540 --> 00:03:48,820
+responsible, but it's not easy to define such a case.
+
+47
+00:03:48,820 --> 00:03:51,460
+Saying that shareholders will be responsible
+
+48
+00:03:51,460 --> 00:03:53,920
+because sometimes we have thousands of
+
+49
+00:03:53,920 --> 00:03:57,820
+shareholders. في بعض الشركات لدينا ملايين من
+
+50
+00:03:57,820 --> 00:04:02,160
+المشاركين، كيف يمكننا... كيف يمكننا أن نتأكد أنهم
+
+51
+00:04:02,160 --> 00:04:06,160
+سيكونون مسؤولين عن أفعال كهذه؟ كيف يمكننا... كيف
+
+52
+00:04:06,160 --> 00:04:10,420
+يمكننا أن نقوم بمحاسبة عدد كبير من الناس عن أفعال
+
+53
+00:04:10,420 --> 00:04:17,880
+التي قامت بها الشركة؟ هذا يجعل رأينا... مسألة
+
+54
+00:04:17,880 --> 00:04:24,650
+مسؤولية الشركة، أو الشركة. هل ستستطيع... لتدفع
+
+55
+00:04:24,650 --> 00:04:30,910
+لهذا الخطأ، أو هذا الخطأ؟ هل الشركة ستكون محكومة لهذا
+
+56
+00:04:30,910 --> 00:04:35,910
+الخطأ؟ إذا كان شخصٌ قُتل، وقد رحل من أجل عملية من
+
+57
+00:04:35,910 --> 00:04:41,630
+شركة، فالشركة... فالشركة ستجب أن تدفع عن هذه الأعمال،
+
+58
+00:04:41,630 --> 00:04:44,850
+ستجب أن تدفع عن هذه الأعمال. هذا يمكن أن يتم دفعه من
+
+59
+00:04:44,850 --> 00:04:49,230
+المشاركين... أعني من المديرين، يمكن أن يتم دفعه من
+
+60
+00:04:49,230 --> 00:04:52,970
+الشركة نفسها، ولكن هذا واحد من الحالات التي لم
+
+61
+00:04:52,970 --> 00:05:00,130
+تتمتع... التي نسميها مشكلة غير ملحوظة. لا نعرف حلًا أخيرًا،
+
+62
+00:05:00,130 --> 00:05:03,390
+لا نعرف حلًا أخيرًا لا نعرف حلًا أخيرًا لا نعرف حلًا أخيرًا لا
+
+63
+00:05:03,390 --> 00:05:04,170
+نعرف حلًا أخيرًا لا نعرف حلًا أخيرًا لا نعرف حلًا أخيرًا لا
+
+64
+00:05:04,170 --> 00:05:05,210
+نعرف حلًا أخيرًا لا نعرف حلًا أخيرًا لا نعرف حلًا أخيرًا لا
+
+65
+00:05:05,210 --> 00:05:05,530
+نعرف حلًا أخيرًا لا نعرف حلًا أخيرًا لا نعرف حلًا أخيرًا لا
+
+66
+00:05:05,530 --> 00:05:05,570
+نعرف حلًا أخيرًا لا نعرف حلًا أخيرًا لا نعرف حلًا أخيرًا لا
+
+67
+00:05:05,570 --> 00:05:06,730
+نعرف حلًا أخيرًا لا نعرف حلًا أخيرًا لا نعرف حلًا أخيرًا لا
+
+68
+00:05:06,730 --> 00:05:08,870
+نعرف حلًا أخيرًا لا نعرف حلًا أخيرًا لا نعرف حلًا أخيرًا لا
+
+69
+00:05:08,870 --> 00:05:18,680
+نعرف حلًا أخيرًا. لو واحد من الموظفين أسبب موت شخص ما،
+
+70
+00:05:18,680 --> 00:05:25,780
+هنا الاختلاف، هنا الاختلاف. الشركة لن تدفع، هي
+
+71
+00:05:25,780 --> 00:05:32,260
+الشخص الذي أسببه. إذا الشركة نفسها أسببت هذه
+
+72
+00:05:32,260 --> 00:05:36,960
+القتل، فهناك الكثير من الآراء. بعضهم ما يقولون أن
+
+73
+00:05:36,960 --> 00:05:41,200
+المشاركين يجب أن يدفعوا، أشخاص آخرين يقولون أن
+
+74
+00:05:41,200 --> 00:05:46,090
+الشركة يجب أن تكون... الشركة يجب أن تكون... until we get
+
+75
+00:05:46,090 --> 00:05:49,790
+to the point in which some scholars even raising
+
+76
+00:05:49,790 --> 00:05:53,890
+the question of the death penalty, saying that the
+
+77
+00:05:53,890 --> 00:05:58,570
+company has to be executed... executed... killed
+
+78
+00:05:58,570 --> 00:06:02,770
+in its life, because the company has ended the life
+
+79
+00:06:02,770 --> 00:06:04,990
+of somebody, then we have to end the life of the
+
+80
+00:06:04,990 --> 00:06:08,350
+company. I mean, we still do not have the answer yet.
+
+81
+00:06:09,560 --> 00:06:12,740
+It it depends on the case, and it depends on each
+
+82
+00:06:12,740 --> 00:06:15,520
+country, what they have. Fine. I think we have to
+
+83
+00:06:15,520 --> 00:06:19,200
+move to the next slide, to the new subject now, in
+
+84
+00:06:19,200 --> 00:06:22,760
+which we have to... we have to differentiate between
+
+85
+00:06:22,760 --> 00:06:26,700
+different types... types of companies and
+
+86
+00:06:26,700 --> 00:06:31,580
+corporations. Oh, it's cold. I see many students
+
+87
+00:06:31,580 --> 00:06:37,740
+today, some of them are late. Fine. Anyway, we have
+
+88
+00:06:37,740 --> 00:06:41,190
+the types... How many types of corporations do we have?
+
+89
+00:06:41,190 --> 00:06:47,570
+Two? Four? Five? How many types of companies do we
+
+90
+00:06:47,570 --> 00:07:00,170
+have? How many? What do you think? Five? Four? It
+
+91
+00:07:00,170 --> 00:07:03,830
+depends
+
+92
+00:07:03,830 --> 00:07:08,440
+on each country. In Palestine, we have لدينا ثلاثة
+
+93
+00:07:08,440 --> 00:07:11,980
+أشكال أساسية من الشركات. In the USA, there might be
+
+94
+00:07:11,980 --> 00:07:14,600
+around 10 forms. I don't know exactly how many forms. This
+
+95
+00:07:14,600 --> 00:07:20,860
+deals with each company. Each country has a different system, but
+
+96
+00:07:20,860 --> 00:07:26,730
+في أكثر مكان وأكثر بلد وأكثر مجال... نحن نحن نحن نحن
+
+97
+00:07:26,730 --> 00:07:28,090
+نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن
+
+98
+00:07:28,090 --> 00:07:30,390
+نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن
+
+99
+00:07:30,390 --> 00:07:31,430
+نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن
+
+100
+00:07:31,430 --> 00:07:33,650
+نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن
+
+101
+00:07:33,650 --> 00:07:35,250
+نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن
+
+102
+00:07:35,250 --> 00:07:53,430
+نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن ن
+
+103
+00:07:53,510 --> 00:07:56,250
+الشركات المالية، أو الشركات المالية، أو الشركات
+
+104
+00:07:56,250 --> 00:07:57,310
+المالية، أو الشركات المالية، أو الشركات المالية، أو
+
+105
+00:07:57,310 --> 00:07:58,730
+الشركات المالية، أو شركات مالية، أو شركات مالية، أو
+
+106
+00:07:58,730 --> 00:07:58,790
+شركات مالية، أو شركات مالية، أو شركات مالية، أو شركات
+
+107
+00:07:58,790 --> 00:08:01,510
+مالية، أو شركات مالية، أو شركات مالية، أو شركات مالية
+
+108
+00:08:01,510 --> 00:08:09,330
+أو شركات مالية، أو شركات مالية، أو شركات مالية، أو
+
+109
+00:08:09,330 --> 00:08:11,010
+شركات مالية، أو شركات مالية، أو شركات مالية، أو شركات
+
+110
+00:08:11,010 --> 00:08:11,070
+مالية، أو شركات مالية، أو شركات مالية، أو شركات مالية
+
+111
+00:08:11,070 --> 00:08:11,610
+أو شركات مالية، أو شركات مالية، أو شركات مالية، أو
+
+112
+00:08:11,610 --> 00:08:13,810
+شركات مالية، أو شركات مالية، أو شركات مالية، أو شركات
+
+113
+00:08:13,810 --> 00:08:18,870
+مالية. The corporation raises its capital by selling
+
+114
+00:08:18,870 --> 00:08:22,430
+the stocks to the stockholders and the general
+
+115
+00:08:22,430 --> 00:08:30,210
+customers. Yes, anyone else? What does it mean
+
+116
+00:08:30,210 --> 00:08:30,630
+stock?
+
+117
+00:08:33,870 --> 00:08:41,050
+Shares? Assets? Money? Profit? It means this
+
+118
+00:08:41,050 --> 00:08:45,580
+company is investing money to make a profit. وهي مجموعة
+
+119
+00:08:45,580 --> 00:08:52,460
+من الناس، مجموعة من الشخصيات، مجموعة لتجنيد المال،
+
+120
+00:08:52,460 --> 00:08:56,640
+لتجنيد أفعال، لتجنيد
+
+121
+00:08:56,640 --> 00:09:00,860
+أفعال، لتجنيد أفعال، لتجنيد أفعال، لتجنيد أفعال،
+
+122
+00:09:00,860 --> 00:09:05,340
+لتجنيد أفعال، لتجنيد أفعال، لتجنيد أفعال، لتجنيد أفعال،
+
+123
+00:09:05,340 --> 00:09:07,200
+لتجنيد أفعال، لتجنيد أفعال، لتجنيد أفعال، لتجنيد أفعال،
+
+124
+00:09:07,200 --> 00:09:07,440
+لتجنيد أفعال، لتجنيد أفعال، لتجنيد أفعال، لتجنيد أفعال،
+
+125
+00:09:07,440 --> 00:09:14,160
+لتجنيد أفعال، لتجنيد أفعال، لتجنيد أفعال، لتجنيد أفعال
+
+126
+00:09:14,810 --> 00:09:21,250
+وهذا الشخص نسميه شركة عامة. وشركات غير عامة ليست
+
+127
+00:09:21,250 --> 00:09:23,110
+كذلك، ليس لدينا شركات عامة، ليس لدينا شركات
+
+128
+00:09:23,110 --> 00:09:24,690
+عامة، ليس لدينا شركات عامة، ليس لدينا شركات
+
+129
+00:09:24,690 --> 00:09:26,570
+عامة، ليس لدينا شركات عامة، ليس لدينا شركات
+
+130
+00:09:26,570 --> 00:09:27,990
+عامة، ليس لدينا شركات عامة، ليس لدينا شركات
+
+131
+00:09:27,990 --> 00:09:28,930
+عامة، ليس لدينا شركات عامة، ليس لدينا شركات
+
+132
+00:09:28,930 --> 00:09:30,250
+عامة، ليس لدينا شركات عامة، ليس لدينا شركات
+
+133
+00:09:30,250 --> 00:09:31,430
+عامة، ليس لدينا شركات عامة، ليس لدينا شركات
+
+134
+00:09:31,430 --> 00:09:36,230
+عامة، ليس
+
+135
+00:09:36,230 --> 00:09:39,530
+لدينا
+
+136
+00:09:39,530 --> 00:09:44,950
+شركات عامة. I'm talking about the business itself. Is it
+
+137
+00:09:44,950 --> 00:09:49,970
+a business, or is it not charity?
+
+138
+00:09:49,970 --> 00:09:55,950
+Yes, this is non-profit. It's a non-profit and it's non-
+
+139
+00:09:55,950 --> 00:09:59,290
+stock. It's not business, it's not profit, it's not
+
+140
+00:09:59,290 --> 00:10:02,690
+money. It's about some activities. Those activities
+
+141
+00:10:02,690 --> 00:10:07,750
+can be charity, helping people.
+
+142
+00:10:12,240 --> 00:10:16,640
+أسلوب الدراسة، مجال الدراسة، مجال الدراسة، مجال
+
+143
+00:10:16,640 --> 00:10:19,020
+الدراسة، مجال الدراسة، مجال الدراسة، مجال الدراسة،
+
+144
+00:10:19,020 --> 00:10:19,660
+مجال الدراسة، مجال الدراسة، مجال الدراسة، مجال
+
+145
+00:10:19,660 --> 00:10:22,040
+الدراسة، مجال الدراسة، مجال الدراسة، مجال الدراسة،
+
+146
+00:10:22,040 --> 00:10:23,620
+مجال الدراسة، مجال الدراسة، مجال الدراسة، مجال
+
+147
+00:10:23,620 --> 00:10:25,540
+الدراسة، مجال الدراسة، مجال الدراسة، مجال الدراسة،
+
+148
+00:10:25,540 --> 00:10:30,720
+مجال الدراسة، مجال الدراسة، مجال الدراسة، مجال
+
+149
+00:10:30,720 --> 00:10:39,960
+الدراسة، مجال الدراسة، مجال الدراسة، مجال
+
+150
+00:10:39,960 --> 00:10:44,810
+الدراسة. الشركات ليس لديها مصادر ولا مال ولا موارد
+
+151
+00:10:44,810 --> 00:10:50,990
+ولا مستثمر ولا أسهم. كل ما لديها هو الهدف أن تفعل
+
+152
+00:10:50,990 --> 00:10:56,430
+شيئًا لفائدة المجتمع العام، أو لفائدة بعض الناس في
+
+153
+00:10:56,430 --> 00:11:02,350
+المجتمع، وبفعل هذا يمكنك أن تحتاج إلى المال لتكون
+
+154
+00:11:02,350 --> 00:11:08,170
+مستثمرًا، ولكن هذا المال فقط لتسهيل... to help you to be
+
+155
+00:11:08,170 --> 00:11:11,630
+able to understand how life can be managed, I mean
+
+156
+00:11:11,630 --> 00:11:14,650
+social life, educational life, how you can help
+
+157
+00:11:14,650 --> 00:11:17,510
+some people in both ways. As you can see, stock and
+
+158
+00:11:17,510 --> 00:11:21,010
+non-stock corporations in United States, like in
+
+159
+00:11:21,010 --> 00:11:23,410
+Washington, for example. Some jurisdictions,
+
+160
+00:11:23,710 --> 00:11:28,750
+jurisdictions، التي هي منطقة اختصاص قانوني، مثلًا
+
+161
+00:11:28,750 --> 00:11:34,570
+مدينة غزة، مدينة نابلس، وكذلك... وكذلك في بعض المدارس
+
+162
+00:11:34,570 --> 00:11:37,870
+الواشنطن دي سي، على سبيل المثال. هنا، على الرغم من
+
+163
+00:11:37,870 --> 00:11:41,790
+الحقيقة أنهم يفرقون بين مصادر ولا مصادر، ولكننا
+
+164
+00:11:41,790 --> 00:11:49,850
+نجد أننا لدينا بعض المشابهات في الموارد، ويسمونهم
+
+165
+00:11:49,850 --> 00:11:54,290
+موارد ولا موارد، موارد ولا موارد. وسنرى لاحقًا في
+
+166
+00:11:54,290 --> 00:11:57,710
+التعليقات التالية... على الرغم من أننا لدينا هنا
+
+167
+00:11:57,710 --> 00:11:59,450
+مجموعات، مستخدمين ومستخدمين ومستخدمين ومستخدمين
+
+168
+00:11:59,450 --> 00:12:07,210
+ومستخدمين ومستخدمين ومستخدمين ومستخدمين
+
+169
+00:12:07,210 --> 00:12:09,530
+ومستخدمين ومستخدمين ومستخدمين ومستخدمين ومستخدمين
+
+170
+00:12:09,530 --> 00:12:09,630
+ومستخدمين ومستخدمين ومستخدمين ومستخدمين ومستخدمين
+
+171
+00:12:09,630 --> 00:12:09,690
+ومستخدمين ومستخدمين ومستخدمين ومستخدمين ومستخدمين
+
+172
+00:12:09,690 --> 00:12:10,230
+ومستخدمين ومستخدمين ومستخدمين ومستخدمين ومستخدمين
+
+173
+00:12:10,230 --> 00:12:12,390
+ومستخدمين ومستخدمين ومستخدمين ومستخدمين ومستخدمين
+
+174
+00:12:12,390 --> 00:12:16,090
+ومستخدمين
+
+175
+00:12:16,090 --> 00:12:25,010
+ومستخدمين
+
+176
+00:12:25,500 --> 00:12:29,380
+profit and non-profit. كما أنه في النظام الاقتصادي
+
+177
+00:12:29,380 --> 00:12:33,700
+التقليدي، التقليدي، التقليدي، التقليدي، التقليدي،
+
+178
+00:12:33,700 --> 00:12:34,100
+التقليدي، التقليدي، التقليدي، التقليدي، التقليدي،
+
+179
+00:12:34,100 --> 00:12:35,
+
+223
+00:15:29,050 --> 00:15:33,270
+الحكومة، ننظر إليها بنفس الطريقة، نأخذ القرار بطريقة
+
+224
+00:15:33,270 --> 00:15:40,340
+مشابهة. الآن يجب أن ننظر إلى قطعة مختلفة تمامًا
+
+225
+00:15:40,340 --> 00:15:45,520
+للنوع من الشركات أو الشركات كما يعرف أكثر منكم
+
+226
+00:15:45,520 --> 00:15:52,770
+عنها. مجلس إدارة الشركات
+
+227
+00:15:52,770 --> 00:15:59,010
+عامة أو خاصة، شركات عامة وخاصة، نسميها أحيانًا
+
+228
+00:15:59,010 --> 00:16:03,330
+شركات عامة وخاصة، شركات عامة وخاصة، شركات عامة و
+
+229
+00:16:03,330 --> 00:16:05,770
+خاصة، شركات عامة وخاصة، شركات عامة وخاصة، شركات
+
+230
+00:16:05,770 --> 00:16:05,810
+شركات عامة وخاصة، شركات عامة وخاصة، شركات عامة و
+
+231
+00:16:05,810 --> 00:16:07,990
+خاصة، شركات عامة وخاصة، شركات عامة وخاصة، شركات
+
+232
+00:16:07,990 --> 00:16:12,150
+عامة وخاصة، شركات عامة وخاصة، شركات عامة وخاصة،
+
+233
+00:16:12,150 --> 00:16:18,130
+شركات عامة وخاصة، شركات
+
+234
+00:16:20,450 --> 00:16:24,930
+هذا ليس موضوع صعب، هذا ليس نقطة صعبة، بسهولة، الشركات
+
+235
+00:16:24,930 --> 00:16:29,150
+تستطيع أن تكون عامة وأحيانًا تستطيع أن تكون خاصة،
+
+236
+00:16:29,150 --> 00:16:32,610
+كيف يكونون يعرفون هذا؟ كيف يمكننا إنشاء شركة عامة؟
+
+237
+00:16:32,610 --> 00:16:35,730
+كيف يمكننا إنشاء شركة خاصة؟ كيف يمكنهم أن يقوموا
+
+238
+00:16:35,730 --> 00:16:41,330
+بنفس الطريقة؟ هل لديهم نفس الوسائل؟ هل لديهم نفس
+
+239
+00:16:41,330 --> 00:16:42,010
+المساعدة؟
+
+240
+00:16:48,080 --> 00:16:53,300
+come on, just try to make mistakes, it's fine. Private
+
+241
+00:16:53,300 --> 00:17:00,280
+company, it's main objective, and others trying to
+
+242
+00:17:00,280 --> 00:17:07,520
+make profit. But most likely, in public companies, provide
+
+243
+00:17:07,520 --> 00:17:12,280
+the service... no, no, this... it's not like this...
+
+244
+00:17:12,280 --> 00:17:15,340
+it's called profit and non-profit, charity or
+
+245
+00:17:15,340 --> 00:17:19,220
+mutual benefit... no, this is not the situation...
+
+246
+00:17:19,220 --> 00:17:20,920
+we're not talking about this... تقول إن هي
+
+247
+00:17:20,920 --> 00:17:24,880
+publicly traded... publicly traded public...
+
+248
+00:17:24,880 --> 00:17:31,440
+publicly funded from the government, but the public... لا
+
+249
+00:17:31,440 --> 00:17:34,860
+..لا.. أنا قلت لك.. حسناً.. تنسى عن شركة عامة
+
+250
+00:17:34,860 --> 00:17:38,600
+..أتكلم عن شركات تُدفع أسهمها للعامة.. شركات تُدفع أسهمها للعامة..
+
+251
+00:17:38,600 --> 00:17:40,760
+شركات تُدفع أسهمها للعامة.. شركات تُدفع أسهمها للعامة.. شركات تُدفع
+
+252
+00:17:40,760 --> 00:17:42,660
+أسهمها للعامة.. شركات تُدفع أسهمها للعامة.. شركات تُدفع أسهمها
+
+253
+00:17:42,660 --> 00:17:43,960
+للعامة.. شركات تُدفع أسهمها للعامة.. شركات تُدفع أسهمها
+
+254
+00:17:43,960 --> 00:17:45,560
+للعامة.. شركات تُدفع أسهمها للعامة.. شركات تُدفع أسهمها
+
+255
+00:17:45,560 --> 00:17:47,660
+للعامة.. شركات تُدفع أسهمها للعامة.. شركات تُدفع أسهمها
+
+256
+00:17:47,660 --> 00:17:53,420
+للعامة.. شركات تُدفع أسهمها للعامة.. شركات تُدفع أسهمها للعامة..
+
+257
+00:17:53,420 --> 00:17:59,900
+هذه الشركات تتمتع بـ.. شركات صغيرة وليست
+
+258
+00:17:59,900 --> 00:18:04,760
+مستعدة لتطبيق
+
+259
+00:18:04,760 --> 00:18:10,300
+خطة لشركات أخرى أو للعامة، Publicly
+
+260
+00:18:10,300 --> 00:18:17,480
+Traded Corporations. لدينا شركة أكثر بكثير من هذه
+
+261
+00:18:17,480 --> 00:18:23,260
+الشركة وشركات Corporations. صحيح، صغيرة. المقال الصغير
+
+262
+00:18:23,260 --> 00:18:25,660
+هنا، إذا كنت تنظر إلى المقال، على سبيل المثال هنا
+
+263
+00:18:25,660 --> 00:18:29,860
+مقال
+
+264
+00:18:29,860 --> 00:18:38,460
+رقم واحد، وانظر إلى الرقمين رقم اثنين. المهم هنا،
+
+265
+00:18:38,460 --> 00:18:43,640
+الموضوع الرئيسي هو مجتمع، مجتمع، مجتمع، مجتمع، مجتمع
+
+266
+00:18:43,640 --> 00:18:44,000
+مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع،
+
+267
+00:18:44,000 --> 00:18:47,000
+مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع،
+
+268
+00:18:47,000 --> 00:18:47,080
+مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع،
+
+269
+00:18:47,080 --> 00:18:47,100
+مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع،
+
+270
+00:18:47,100 --> 00:18:51,970
+مجتمع، مجتمع، مجتمع. كم منهم لدينا مثلًا في فلسطين؟
+
+271
+00:18:51,970 --> 00:18:56,030
+لدينا أقل من 40 شركة.
+
+272
+00:18:59,620 --> 00:19:03,160
+في أمريكا، على سبيل المثال، لدينا في نيويورك
+
+273
+00:19:03,160 --> 00:19:11,660
+محافظة عامة، عامة، عامة، عامة، عامة، عامة، عامة، عامة،
+
+274
+00:19:11,660 --> 00:19:12,220
+عامة، عامة، عامة، عامة، عامة، عامة، عامة، عامة، عامة
+
+275
+00:19:12,220 --> 00:19:12,480
+عامة، عامة، عامة، عامة، عامة، عامة، عامة، عامة، عامة
+
+276
+00:19:12,480 --> 00:19:12,560
+عامة، عامة، عامة، عامة، عامة، عامة، عامة، عامة، عامة
+
+277
+00:19:12,560 --> 00:19:12,580
+عامة، عامة، عامة، عامة، عامة، عامة، عامة، عامة، عامة
+
+278
+00:19:12,580 --> 00:19:13,180
+عامة، عامة، عامة، عامة، عامة، عامة، عامة، عامة، عامة
+
+279
+00:19:13,180 --> 00:19:19,910
+عامة، عامة، عامة، عامة، عامة، عامة، عامة. مفروض لأي شخص
+
+280
+00:19:19,910 --> 00:19:23,270
+يمكنك أن تشتري شركات. كثير مما تستطيع أن تشتري.
+
+281
+00:19:23,270 --> 00:19:24,890
+تستطيع أن تتعامل، تستطيع أن تتعامل، تستطيع أن تتعامل،
+
+282
+00:19:24,890 --> 00:19:26,070
+تستطيع أن تتعامل، تستطيع أن تتعامل، تستطيع أن تتعامل،
+
+283
+00:19:26,070 --> 00:19:27,510
+تستطيع أن تتعامل، تستطيع أن تتعامل، تستطيع أن تتعامل،
+
+284
+00:19:27,510 --> 00:19:28,930
+تستطيع أن تتعامل، تستطيع أن تتعامل، تستطيع أن تتعامل،
+
+285
+00:19:28,930 --> 00:19:29,030
+تستطيع أن تتعامل، تستطيع أن تتعامل، تستطيع أن تتعامل،
+
+286
+00:19:29,030 --> 00:19:33,090
+تستطيع أن تتعامل، تستطيع أن تتعامل، تستطيع أن تتعامل،
+
+287
+00:19:33,090 --> 00:19:43,970
+تستطيع
+
+288
+00:19:43,970 --> 00:19:48,820
+أن تتعامل.الفرق الرئيسي بين مجلس إدارة، ومجلس إدارة.. أعني
+
+289
+00:19:48,820 --> 00:19:53,500
+مجلس إدارة، ومجلس إدارة، ومجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة،
+
+290
+00:19:53,500 --> 00:19:57,040
+مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة،
+
+291
+00:19:57,040 --> 00:19:57,760
+مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة،
+
+292
+00:19:57,760 --> 00:19:57,860
+مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة،
+
+293
+00:19:57,860 --> 00:20:07,340
+مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة، مجلس إدارة، مج
+
+294
+00:20:07,460 --> 00:20:10,900
+الـ.. البورصة.. البورصة. Like in Palestine, we
+
+295
+00:20:10,900 --> 00:20:13,340
+have the Bank of Palestine, we have the Jowal Company, we
+
+296
+00:20:13,340 --> 00:20:19,560
+have Baltil, I guess. We have about 37 corporations
+
+297
+00:20:19,560 --> 00:20:25,220
+are listed on the stock exchange market. So you can
+
+298
+00:20:25,220 --> 00:20:28,160
+go to that market, you can buy shares, then you
+
+299
+00:20:28,160 --> 00:20:32,160
+can exchange, you can sell them if you want. And it
+
+300
+00:20:32,160 --> 00:20:38,020
+means here, those corporations in size... الأكبر.. هم
+
+301
+00:20:38,020 --> 00:20:43,460
+الأكبر في حجمهم.. أكبر شركة في العالم. شركات
+
+302
+00:20:43,460 --> 00:20:45,680
+تتعامل بشكل مجتمعي، بشكل مجتمعي، بشكل مجتمعي، بشكل مجتمعي،
+
+303
+00:20:45,680 --> 00:20:46,120
+بشكل مجتمعي، بشكل مجتمعي، بشكل مجتمعي، بشكل مجتمعي، بشكل
+
+304
+00:20:46,120 --> 00:20:46,420
+مجتمعي، بشكل مجتمعي، بشكل مجتمعي، بشكل مجتمعي، بشكل مجتمعي،
+
+305
+00:20:46,420 --> 00:20:47,540
+بشكل مجتمعي، بشكل مجتمعي، بشكل مجتمعي، بشكل مجتمعي، بشكل
+
+306
+00:20:47,540 --> 00:20:49,100
+مجتمعي، بشكل مجتمعي، بشكل مجتمعي، بشكل مجتمعي، بشكل مجتمعي،
+
+307
+00:20:49,100 --> 00:20:52,000
+بشكل مجتمعي، بشكل مجتمعي، بشكل مجتمعي، بشكل مجتمعي، بشكل
+
+308
+00:20:52,000 --> 00:20:57,200
+مجتمعي
+
+309
+00:20:57,200 --> 00:20:58,920
+بـ
+
+310
+00:21:04,040 --> 00:21:06,660
+نعرف بعضنا البعض و نثق ببعضنا البعض في شركات
+
+311
+00:21:06,660 --> 00:21:07,620
+مترابطة مع بعضنا البعض، مترابطة مع بعضنا البعض، مترابطة
+
+312
+00:21:07,620 --> 00:21:08,780
+مع بعضنا البعض، مترابطة مع بعضنا البعض، مترابطة مع
+
+313
+00:21:08,780 --> 00:21:11,140
+بعضنا البعض، مترابطة مع بعضنا البعض، مترابطة مع بعضنا
+
+314
+00:21:11,140 --> 00:21:12,760
+البعض، مترابطة مع بعضنا البعض، مترابطة مع بعضنا البعض،
+
+315
+00:21:12,760 --> 00:21:13,120
+مع بعضنا البعض، مترابطة مع بعضنا البعض، مترابطة مع
+
+316
+00:21:13,120 --> 00:21:18,660
+بعضنا البعض، مترابطة مع بعضنا البعض، مترابطة مع بعضنا
+
+317
+00:21:18,660 --> 00:21:33,360
+البعض، مترابطة
+
+318
+00:21:33,360 --> 00:21:36,510
+مع بعضنا. يمكنك أن تعرف عدد المال الذي تستخدمه، ولكن
+
+319
+00:21:36,510 --> 00:21:37,450
+عندما يتعلق الأمر بالشركات التي تتعامل بشكل عام، بشكل عام،
+
+320
+00:21:37,450 --> 00:21:38,630
+بشكل عام، بشكل عام، بشكل عام، بشكل عام، بشكل عام، بشكل
+
+321
+00:21:38,630 --> 00:21:40,870
+عام، بشكل عام، بشكل عام، بشكل عام، بشكل عام، بشكل عام،
+
+322
+00:21:40,870 --> 00:21:41,290
+بشكل عام، بشكل عام، بشكل عام، بشكل عام، بشكل عام، بشكل
+
+323
+00:21:41,290 --> 00:21:42,070
+عام، بشكل عام، بشكل عام، بشكل عام، بشكل عام، بشكل عام،
+
+324
+00:21:42,070 --> 00:21:43,690
+بشكل عام، بشكل عام، بشكل عام، بشكل عام، بشكل عام، بشكل
+
+325
+00:21:43,690 --> 00:21:44,470
+عام، بشكل عام، بشكل عام، بشكل عام، بشكل عام، بشكل عام،
+
+326
+00:21:44,470 --> 00:21:51,050
+بشكل عام، بشكل
+
+327
+00:21:51,050 --> 00:22:00,170
+عام، بشكل
+
+328
+00:22:01,350 --> 00:22:06,790
+معظمهم رقم.. كم.. في فلسطين لدينا ألف شركة..
+
+329
+00:22:06,790 --> 00:22:10,890
+لدينا ألف شركة.. كم.. كم منهم يتعاملون بشكل
+
+330
+00:22:10,890 --> 00:22:18,310
+مباشر في سوق المجتمع؟ أعتقد أنه فقط 37.. فقط 37
+
+331
+00:22:18,310 --> 00:22:22,530
+شركة.. أنا لست متأكداً من الرقم.. لكنه أكثر أو
+
+332
+00:22:22,530 --> 00:22:27,110
+أقل.. 37 شركة موجودة فقط في سوق المجتمع
+
+333
+00:22:27,110 --> 00:22:34,820
+الفلسطيني.. فقط. والباقي منهم محافظة قريبة من شركات
+
+334
+00:22:34,820 --> 00:22:38,880
+خاصة، لأنك لتكون مدرجاً.. لكي تكون مدرجاً في السوق
+
+335
+00:22:38,880 --> 00:22:43,100
+الـStock Exchange Market، يجب أن تكون كبيراً في حجمك، تستثمر في
+
+336
+00:22:43,100 --> 00:22:46,780
+ملايين وملايين من الدولارات، ويجب أن تكون
+
+337
+00:22:46,780 --> 00:22:49,520
+لديك المسؤولية، يجب أن تكون لديك بعض الوضوح، ليس
+
+338
+00:22:49,520 --> 00:22:53,560
+بسهولة أن تقوم وتضع اسمك في سوق الـStock Exchange، لأنك
+
+339
+00:22:53,560 --> 00:22:59,580
+لديك خطر، أو مخاطر، يمكن أن تخسر التحكم. يجب أن تتعامل
+
+340
+00:22:59,580 --> 00:23:02,600
+مع النظام. في المقاطع التالية التي ستشاهدها،
+
+341
+00:23:02,600 --> 00:23:06,620
+الاختلاف المهم هو الاختلاف بين شركة عامة وشركة
+
+342
+00:23:06,620 --> 00:23:11,520
+خاصة، إنها تتعامل مع متطلبات، ومتطلبات قانونية، كيف
+
+343
+00:23:11,520 --> 00:23:15,460
+يمكننا أن نجعل الأشياء تتعامل مع هذا النوع من
+
+344
+00:23:15,460 --> 00:23:19,220
+الشركات؟ لأن استثمار المال كذلك في شركات تتعامل مع
+
+345
+00:23:19,220 --> 00:23:23,320
+المجتمع، وإذا كان لدينا انهيار هنا،
+
+346
+00:23:23,320 --> 00:23:29,400
+ثم سيؤثر على آلاف الأشخاص من الناس، ولكن عندما يتعلق الأمر
+
+347
+00:23:29,400 --> 00:23:34,860
+بالخصوصية، بالشركات الخاصة، فهو
+
+348
+00:23:34,860 --> 00:23:38,040
+فقط عدد صغير من المال، عدد صغير من المال المُستَخدم،
+
+349
+00:23:38,040 --> 00:23:43,080
+وعدد صغير من الناس، الشركات، لذا حتى إذا كنا نخسر
+
+350
+00:23:43,080 --> 00:23:46,780
+هذه الشركة، حتى إذا كان لدينا نهاية حياتها، فهذا
+
+351
+00:23:46,780 --> 00:23:53,400
+لن يؤثر على المجتمع في البلد، لن يفعل ذلك. وحتى و
+
+352
+00:23:53,400 --> 00:23:58,700
+رغم ما أقوله الآن، أحيانًا نجد شركات مترابطة بشكل
+
+353
+00:23:58,700 --> 00:24:04,120
+عالي، بقوة كبيرة، أعني لن يوقفوا هذه الشركات
+
+354
+00:24:04,120 --> 00:24:06,280
+المتّصلة بشكل عالي، شركات متّصلة بشكل عالي، شركات
+
+355
+00:24:06,280 --> 00:24:09,100
+متّصلة بشكل عالٍ، لن توقفوا، لن توقفوا في نقطة
+
+356
+00:24:09,100 --> 00:24:09,340
+واحدة، لن توقفوا، لن توقفوا، لن توقفوا في نقطة
+
+357
+00:24:09,340 --> 00:24:13,600
+واحدة، لن توقفوا، لن توقفوا، لن توقفوا، لن توقفوا،
+
+358
+00:24:13,600 --> 00:24:15,300
+لن توقفوا، لن توقفوا، لن توقفوا، لن توقفوا، لن
+
+359
+00:24:15,300 --> 00:24:23,900
+توقفوا، لن توقفوا. بعض هذه الشركات ممكن تكون كبيرة، و
+
+360
+00:24:23,900 --> 00:24:26,680
+كبيرة من الشركات المُشترَكة، بشكل عام، عام، بشكل
+
+361
+00:24:26,680 --> 00:24:27,640
+عام، بشكل عام، بشكل عام، بشكل عام، بشكل عام، بشكل عام،
+
+362
+00:24:27,640 --> 00:24:30,340
+بشكل عام، بشكل عام، بشكل عام، بشكل عام، بشكل عام، بشكل
+
+363
+00:24:30,340 --> 00:24:30,460
+عام، بشكل عام، بشكل عام، بشكل عام، بشكل عام، بشكل عام،
+
+364
+00:24:30,460 --> 00:24:31,560
+بشكل عام، بشكل عام، بشكل عام، بشكل عام، بشكل عام، بشكل
+
+365
+00:24:31,560 --> 00:24:33,940
+عام، بشكل عام، بشكل عام، بشكل عام، بشكل عام، بشكل
+
+366
+00:24:33,940 --> 00:24:46,100
+عام، بشكل عام، بشكل عام، بشكل عام،
+
+367
+00:24:46,100 --> 00:24:54,820
+بـ.المفادة، والمفادة، مجتمعي، مجتمعي، أكثر المفادات
+
+368
+00:24:54,820 --> 00:25:01,560
+المرتبطة بـ Closely Held، نجدها سهلة. تبني شركة مجتمعية،
+
+369
+00:25:01,560 --> 00:25:04,200
+مجتمعية، مجتمعية، مجتمعية، مجتمعية، مجتمعية، مجتمعية، مجتمعية، مجتمعية،
+
+370
+00:25:04,200 --> 00:25:05,520
+مجتمعية، مجتمعية، مجتمعية، مجتمعية، مجتمعية، مجتمعية، مجتمعية، مجتمعية،
+
+371
+00:25:05,520 --> 00:25:06,020
+مجتمعية، مجتمعية، مجتمعية، مجتمعية، مجتمعية، مجتمعية، مجتمعية، مجتمعية،
+
+372
+00:25:06,020 --> 00:25:06,760
+مجتمعية، مجتمعية، مجتمعية، مجتمعية، مجتمعية، مجتمعية، مجتمعية، مجتمعية،
+
+373
+00:25:06,760 --> 00:25:17,060
+مجتمعية، مجتمعية، مجتم
+
+374
+00:25:17,850 --> 00:25:21,330
+لِلشركات المجتمعية. دعونا ننظر لهم واحدًا على واحد.
+
+375
+00:25:21,330 --> 00:25:26,790
+الاختيارات هي أسهل، أن تقوم بالاختيارات في شركة
+
+376
+00:25:26,790 --> 00:25:30,890
+خاصة، إذا كان لدينا عدد صغير من الناس، مثل 20 أو 25
+
+377
+00:25:30,890 --> 00:25:35,170
+طالبًا هنا، ليس صعبًا أن تقوم بالاختيارات، لكن إذا كان
+
+378
+00:25:35,170 --> 00:25:39,750
+لدينا 250 طالبًا، سيكون صعبًا قليلاً. إذا كان لديك 20
+
+379
+00:25:39,750 --> 00:25:44,710
+ألف طالب، it's even more difficult. Now, same thing
+
+380
+00:25:44,710 --> 00:25:47,210
+with companies. If you have a small number, like
+
+381
+00:25:47,210 --> 00:25:51,570
+Closely Held companies, often make company, yeah, a
+
+382
+00:25:51,570 --> 00:25:55,530
+changing decision, or decisions, much more rapidly,
+
+383
+00:25:55,530 --> 00:26:00,590
+rapidly, easily, fast, faster than
+
+384
+00:26:22,130 --> 00:26:24,470
+بعض الناس تتعامل بشركة مجتمعية، بشركة مجتمعية، بشركة
+
+385
+00:26:24,470 --> 00:26:25,210
+مجتمعية، بشركة مجتمعية، بشركة مجتمعية، بشركة مجتمعية، بشركة
+
+386
+00:26:25,210 --> 00:26:25,230
+مجتمعية، بشركة مجتمعية، بشركة مجتمعية، بشركة مجتمعية، بشركة
+
+387
+00:26:25,830 --> 00:26:28,610
+I'm being in one place and having the trust with
+
+388
+00:26:28,610 --> 00:26:31,170
+the people and the society, and it's a little bit
+
+389
+00:26:31,170 --> 00:26:33,770
+difficult or complicated here, but it's talking
+
+390
+00:26:33,770 --> 00:26:38,630
+about the community. مجتمع. أكثر شركات صغيرة، صغيرة
+
+391
+00:26:38,630 --> 00:26:42,590
+شركات مُستَخدَمة بشكل جيد، مستخدمة بشكل جيد في واحد
+
+392
+00:26:42,590 --> 00:26:47,090
+مكان. أكثر شركات صغيرة خاصة، تستطيع أن
+
+445
+00:30:29,000 --> 00:30:33,600
+in and out and delegate them throughout our
+
+446
+00:30:33,600 --> 00:30:37,600
+company. Okay, in public companies, publicly traded
+
+447
+00:30:37,600 --> 00:30:41,480
+companies, it's easy to make money; it's easy to
+
+448
+00:30:41,480 --> 00:30:45,400
+raise the capital and to increase the number of
+
+449
+00:30:45,400 --> 00:30:49,540
+shareholders, and this is an advantage because once
+
+450
+00:30:49,540 --> 00:30:53,100
+we increase the capital, the money, and once we have
+
+451
+00:30:53,100 --> 00:30:55,780
+many shareholders, then we're going to be able to
+
+452
+00:30:55,780 --> 00:30:57,580
+make more business and to
+
+453
+00:31:01,340 --> 00:31:05,580
+وهذا لا يمكن أن يكون شيء موجود في شركات صغيرة أو
+
+454
+00:31:05,580 --> 00:31:09,480
+شركات خاصة لأن هذه الشركات الخاصة لن تدفع الكثير
+
+455
+00:31:09,480 --> 00:31:16,320
+من المال  بما يدفعه شركات عامة. شركات
+
+456
+00:31:16,320 --> 00:31:20,520
+عامة أو شركات عامة أو شركات عامة أو شركات
+
+457
+00:31:20,520 --> 00:31:23,600
+عامة أو شركات عامة أو شركات عامة أو شركات
+
+458
+00:31:23,600 --> 00:31:23,620
+عامة أو شركات عامة أو شركات عامة أو شركات
+
+459
+00:31:23,620 --> 00:31:25,260
+عامة أو شركات عامة أو شركات عامة أو شركات
+
+460
+00:31:25,260 --> 00:31:25,500
+عامة
+
+461
+00:31:31,380 --> 00:31:35,900
+ننظر إلى الفوضى في الشركات التي تعمل بشكل عام، بشكل
+
+462
+00:31:35,900 --> 00:31:40,170
+عام، بشكل عام، بشكل عام.  وللمقارنة، تجد هنا رقم
+
+463
+00:31:40,170 --> 00:31:41,750
+واحد، اثنان، اثنان، اثنان، اثنان، اثنان، اثنان،
+
+464
+00:31:41,750 --> 00:31:42,410
+اثنان، اثنان، اثنان، اثنان، اثنان، اثنان، اثنان،
+
+465
+00:31:42,410 --> 00:31:51,870
+اثنان، اثنان، اثنان، اثنان، اثنان، اثنان، اثنان،
+
+466
+00:31:51,870 --> 00:31:51,910
+اثنان، اثنان، اثنان، اثنان، اثنان، اثنان، اثنان،
+
+467
+00:31:51,910 --> 00:31:52,210
+اثنان، اثنان، اثنان، اثنان، اثنان، اثنان، اثنان،
+
+468
+00:31:52,210 --> 00:32:06,670
+اثنان، اثنان، اثنان، اثنان، اثنان، اثنان، اثنان،
+
+469
+00:32:07,280 --> 00:32:15,780
+الدفع المالي الذي نستخدمه، المال الذي نستخدمه، قيمة
+
+470
+00:32:15,780 --> 00:32:17,340
+الشركة التي نستخدمها، قيمة الشركة التي نستخدمها،
+
+471
+00:32:17,340 --> 00:32:19,240
+قيمة الشركة التي نستخدمها، قيمة الشركة التي
+
+472
+00:32:19,240 --> 00:32:19,660
+نستخدمها، قيمة الشركة التي نستخدمها، قيمة الشركة
+
+473
+00:32:19,660 --> 00:32:19,860
+التي نستخدمها، قيمة الشركة التي نستخدمها، قيمة
+
+474
+00:32:19,860 --> 00:32:20,280
+الشركة التي نستخدمها، قيمة الشركة التي نستخدمها
+
+475
+00:32:20,280 --> 00:32:23,860
+قيمة الشركة التي نستخدمها، قيمة الشركة التي
+
+476
+00:32:23,860 --> 00:32:27,620
+نستخدمها، قيمة الشركة التي نستخدمها، قيمة الشركة
+
+477
+00:32:27,620 --> 00:32:28,960
+التي نستخدمها، قيمة الشركة التي نستخدمها، قيمة
+
+478
+00:32:28,960 --> 00:32:32,600
+الشركة التي نستخدمها، قيمة
+
+479
+00:32:32,600 --> 00:32:34,180
+الشركة
+
+480
+00:32:38,110 --> 00:32:42,090
+العامة تتعامل بشكل كبير، بسبب استخدام المال ليس فقط
+
+481
+00:32:42,090 --> 00:32:48,050
+بسبب ما تفعله الشركة، أحيانًا المال أو المال الذي
+
+482
+00:32:48,050 --> 00:32:52,710
+نستخدمه يمكن أن يتأثر بشكل أفضل، أو أفضل بسبب العمل
+
+483
+00:32:52,710 --> 00:32:57,590
+في الشركة، ومع كم مال يتعاملون؟ مال يقومون
+
+484
+00:32:57,590 --> 00:33:01,530
+باستخدامه؟ كم أشياء يمكنهم فعلها في السوق كل
+
+485
+00:33:01,530 --> 00:33:06,090
+أسبوع؟ كم من مستخدمين يمتلكونها؟ ليس فقط هذا، ولكن حتى
+
+486
+00:33:06,090 --> 00:33:13,590
+قيمة تلك الشركة تتأثر من السوق، من المنافسين، من
+
+487
+00:33:13,590 --> 00:33:17,830
+المنافسين، لأن هذه ليست الشركة الوحيدة، ليس كذلك،
+
+488
+00:33:17,830 --> 00:33:21,490
+لدينا ملايين، لدينا آلاف شركات، آلاف
+
+489
+00:33:23,700 --> 00:33:31,660
+مؤسسات صغيرة، صغيرة، مؤسسات خاصة في شركات خاصة، لأن
+
+490
+00:33:31,660 --> 00:33:35,960
+الشركات الخاصة تبقى، تبقى قيمتها محددة، المال المستخدم
+
+491
+00:33:35,960 --> 00:33:40,660
+في السوق وربما يتأثروا، لكنهم لن يتأثروا كثيرًا مثل
+
+492
+00:33:40,660 --> 00:33:47,540
+شركات عامة، شركات عامة، تتأثر بسهولة، تتأثر بالسوق،
+
+493
+00:33:47,540 --> 00:33:50,840
+أحيانًا ترى، إذا كنت تنظر إلى ناسداك
+
+494
+00:33:53,230 --> 00:33:56,850
+أو بورصة نيويورك أو بورصة طوكيو،
+
+495
+00:33:56,850 --> 00:34:01,710
+تجد في بعض الأحيان إشارة تزداد، و تزداد، و تزداد،
+
+496
+00:34:01,710 --> 00:34:05,490
+تزداد،
+
+497
+00:34:05,490 --> 00:34:10,270
+تزداد، تزداد، تزداد، تزداد، تزداد، تزداد، تزداد، تزداد،
+
+498
+00:34:10,270 --> 00:34:13,580
+تزداد، تزداد، تزداد. إذا كنا مجلدين، مجلدين، لن نكون
+
+499
+00:34:13,580 --> 00:34:16,620
+قادرين على التحكم في كل شيء، لديك السوق، لديك
+
+500
+00:34:16,620 --> 00:34:20,180
+المشاركين، يجب أن تقاتلوا معهم، ويؤثرون على مالكك.
+
+501
+00:34:20,180 --> 00:34:24,760
+وهذا ليس أفضل، هذا أفضل للشركة
+
+502
+00:34:31,460 --> 00:34:32,800
+مؤسسات، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع،
+
+503
+00:34:32,800 --> 00:34:36,420
+مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع،
+
+504
+00:34:36,420 --> 00:34:41,900
+مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع،
+
+505
+00:34:41,900 --> 00:34:46,040
+مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع،
+
+506
+00:34:46,040 --> 00:34:46,480
+مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع،
+
+507
+00:34:46,480 --> 00:34:47,580
+مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع،
+
+508
+00:34:47,580 --> 00:34:58,180
+مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع، مجتمع،
+
+509
+00:34:59,400 --> 00:35:03,200
+it's the scrutiny; scrutiny هو الدقة، extreme in
+
+510
+00:35:03,200 --> 00:35:07,520
+publicly traded companies. We have scrutiny, دقة. We
+
+511
+00:35:07,520 --> 00:35:12,280
+have extreme procedures; we have tighter procedures.
+
+512
+00:35:12,280 --> 00:35:15,060
+If you would like to establish a public company,
+
+513
+00:35:15,060 --> 00:35:18,960
+it's too difficult; it's not easy. You have to go
+
+514
+00:35:18,960 --> 00:35:23,540
+through lots of procedures, and time, and money, and
+
+515
+00:35:23,540 --> 00:35:25,840
+complications. If you would like to have a small
+
+516
+00:35:25,840 --> 00:35:31,620
+company in size، وشركة خاصة، ليس صعبًا، سيكون أسهل
+
+517
+00:35:31,620 --> 00:35:32,780
+من الحصول على شركة عامة.
+
+518
+00:35:32,780 --> 00:35:35,660
+عامة، عامة، عامة، عامة، عامة، عامة، عامة، عامة،
+
+519
+00:35:35,660 --> 00:35:36,640
+عامة، عامة، عامة، عامة، عامة، عامة، عامة، عامة،
+
+520
+00:35:36,640 --> 00:35:37,360
+عامة، عامة، عامة، عامة، عامة، عامة، عامة، عامة،
+
+521
+00:35:37,360 --> 00:35:38,000
+عامة، عامة، عامة، عامة، عامة، عامة، عامة، عامة،
+
+522
+00:35:38,000 --> 00:35:38,260
+عامة، عامة، عامة، عامة، عامة، عامة، عامة، عامة،
+
+523
+00:35:38,260 --> 00:35:48,360
+عامة، عامة، عامة،
+
+524
+00:35:48,880 --> 00:35:52,900
+كيف تحصل على هذا المال؟ كم مالًا ربحت هذه السنة؟ هذا
+
+525
+00:35:52,900 --> 00:35:59,300
+سيزيد المشكلة أكثر من الممكن أن شركات مثلها تبقى في
+
+526
+00:35:59,300 --> 00:36:07,000
+السوق، إذا لم تتبع القواعد القانونية، فهذا سيؤثر على
+
+527
+00:36:07,000 --> 00:36:11,440
+المستثمرين بطريقة سيئة؛ بعضهم سيغادرون، وإذا كان لديك
+
+528
+00:36:11,440 --> 00:36:15,360
+بعض المستثمرين يغادرون الشركة، هذا سيؤثر بطريقة سيئة،
+
+529
+00:36:15,360 --> 00:36:20,140
+بطريقة سلبية، وقد تغلق في نهاية اليوم بعض الشركات.
+
+530
+00:36:20,140 --> 00:36:26,640
+في هذا، يمكن أن يتأثر هذا. هذه هي النقطة الأساسية، لأن شركات
+
+531
+00:36:26,640 --> 00:36:33,040
+صغيرة ستكون مراقبة، ستكون مراقبة. شركات، شركات
+
+532
+00:36:33,040 --> 00:36:39,270
+ولكن شركات كبيرة، شركات، شركات عامة، سيكون لديهم مستثمرين،
+
+533
+00:36:39,270 --> 00:36:41,490
+ولكن ليسوا بنفس الطريقة، إنهم ليسوا بنفس
+
+534
+00:36:41,490 --> 00:36:44,710
+الطريقة. الشركات العامة ستكون لديها عاملات قوية،
+
+535
+00:36:44,710 --> 00:36:51,110
+وسيكون لديها مراقبة طويلة الأمد من المستثمرين، ومراقبة، لأنهم
+
+536
+00:36:51,110 --> 00:36:53,770
+يستخدمون الكثير من المال، مليون ومليون وجنية و
+
+537
+00:36:53,770 --> 00:36:58,100
+دولار، فيجب أن نتأكد أن كل شيء يتحرك في
+
+538
+00:36:58,100 --> 00:37:02,540
+الطريق الصحيح، وكما قلت في البداية، هذا سيجعل بعض
+
+539
+00:37:02,540 --> 00:37:08,600
+الشركات تتخيل أنها مستقبلات أو لا، لأنك لن تعرف في
+
+540
+00:37:08,600 --> 00:37:13,600
+المستقبل ماذا سيحدث لك ولشركتك، وهذا سيؤثر عليها
+
+541
+00:37:13,600 --> 00:37:18,160
+بشكل سلبي، ليس مثل... ليس مثل شركات خاصة، وشركات
+
+542
+00:37:18,160 --> 00:37:23,260
+خاصة صغيرة، وصغيرة من الناس. نعرف مدى المال، نعرف
+
+543
+00:37:23,260 --> 00:37:28,830
+كل شيء، وكيف يمكن أن يتم كل شيء. والنقطة الثالثة
+
+544
+00:37:28,830 --> 00:37:32,650
+المهمة هنا، كما ذكرت في الشريحة السابقة، كنت أتحدث
+
+545
+00:37:32,650 --> 00:37:38,850
+عن العلاقة بين العاملين، العاملين، و... العاملين...
+
+546
+00:37:38,850 --> 00:37:43,650
+ومؤسسات الشركة. في شركات صغيرة، شركات صغيرة،
+
+547
+00:37:43,650 --> 00:37:50,210
+لدينا علاقة قوية بين مؤسسات الشركة، ومؤسسات الشركة
+
+548
+00:37:50,210 --> 00:37:51,530
+ومؤسسات الشركة، ومؤسسات الشركة، ومؤسسات الشركة
+
+549
+00:37:51,530 --> 00:37:51,630
+ومؤسسات الشركة، ومؤسسات الشركة، ومؤسسات الشركة
+
+550
+00:37:51,630 --> 00:37:51,670
+ومؤسسات الشركة، ومؤسسات الشركة، ومؤسسات الشركة
+
+551
+00:37:51,670 --> 00:37:52,190
+ومؤسسات الشركة، ومؤسسات الشركة، ومؤسسات الشركة
+
+552
+00:37:52,190 --> 00:37:54,810
+ومؤسسات الشركة، ومؤسسات الشركة. الشركات العامة ليست كذلك،
+
+553
+00:37:54,810 --> 00:37:56,710
+الشركات العامة ليست كذلك، الشركات العامة ليست
+
+554
+00:37:56,710 --> 00:37:56,750
+كذلك، الشركات العامة ليست كذلك، الشركات العامة
+
+555
+00:37:56,750 --> 00:37:57,010
+ليست كذلك، الشركات العامة ليست كذلك، الشركات
+
+556
+00:37:57,010 --> 00:37:57,870
+العامة ليست كذلك، الشركات العامة ليست كذلك،
+
+557
+00:37:57,870 --> 00:38:00,510
+الشركات العامة ليست كذلك، الشركات العامة ليست
+
+558
+00:38:00,510 --> 00:38:01,730
+كذلك، الشركات العامة ليست كذلك، الشركات العامة
+
+559
+00:38:01,730 --> 00:38:03,830
+ليست كذلك، الشركات العامة ليست كذلك، الشركات
+
+560
+00:38:03,830 --> 00:38:07,570
+العامة ليست كذلك، الشركات العامة ليست كذلك،
+
+561
+00:38:07,570 --> 00:38:10,850
+الشركات العامة ليست كذلك.
+
+562
+00:38:14,840 --> 00:38:18,940
+والشركة لن تكون قادرة على الرحيل كما كانت في السنة
+
+563
+00:38:18,940 --> 00:38:22,660
+السابقة أو السنة التي قبلها، لأن أكثر الناس الذين يكونون
+
+564
+00:38:22,660 --> 00:38:28,220
+متأثرين هنا ليسوا الشركات، والأكثر منهم سيكونون الموظفون.
+
+565
+00:38:28,220 --> 00:38:34,440
+يمكنهم أن يقطعوا وقت العمل، يقللوا عدد الموظفين، و
+
+566
+00:38:34,440 --> 00:38:39,440
+العاملين، ويمكنهم أيضًا أن يقطعوا المساعدة والمبادرات. كل
+
+567
+00:38:39,440 --> 00:38:49,030
+شيء هنا يمكن استخدامه ضد الشركة، وهذا لأن لدينا
+
+568
+00:38:49,030 --> 00:38:53,530
+عددًا كبيرًا من الموظفين والعاملين، ولن نكون قادرين
+
+569
+00:38:53,530 --> 00:38:57,470
+على تغطية كل الأسعار، يكلفون الكثير من المال، مليون
+
+570
+00:38:57,470 --> 00:39:03,890
+ومليون، ثم لتدفعهم لن يكون صحيحًا لشركة، تدفع كل
+
+571
+00:39:03,890 --> 00:39:07,860
+هؤلاء الناس.  The only way for them is to cut the
+
+572
+00:39:07,860 --> 00:39:11,000
+hours or to reduce the number of employees, and you
+
+573
+00:39:11,000 --> 00:39:13,080
+have seen... you have seen many examples in the
+
+574
+00:39:13,080 --> 00:39:17,620
+past few years in Spain, in Italy, in the United
+
+575
+00:39:17,620 --> 00:39:21,420
+States, in the UK, in many other countries, in Greece,
+
+576
+00:39:22,680 --> 00:39:24,880
+cutting the number of employees; many people
+
+577
+00:39:24,880 --> 00:39:29,000
+become  أشخاص غير موظفين، غير موظفين، لا يمكنهم أن
+
+578
+00:39:29,000 --> 00:39:31,760
+يجدوا أي عمل، لا يمكنهم أن يجدوا أي شيء ليفعلوه،
+
+579
+00:39:31,760 --> 00:39:35,740
+والدولة يجب أن تدفع لهم، والدولة يجب أن تدفع لهم
+
+580
+00:39:35,740 --> 00:39:40,960
+بالفوائد باعتبار نظام البطالة، نظام البطالة،
+
+581
+00:39:40,960 --> 00:39:47,840
+ومفاجأة أخرى لشركة خاصة هنا هي شركات
+
+582
+00:39:47,840 --> 00:39:51,640
+خاصة. في المعاملات، تستطيع دفع المال
+
+583
+00:39:54,510 --> 00:39:59,410
+بسبب أننا في بعض الأحيان حالة مثل هذه مستحيلة، غير
+
+584
+00:39:59,410 --> 00:40:05,290
+محددة، مستحيلة.
+
+585
+00:40:05,290 --> 00:40:11,210
+غير محددة، مستحيلة، غير محددة، مستحيلة، غير محددة،
+
+586
+00:40:11,210 --> 00:40:13,550
+مستحيلة، غير محددة، مستحيلة، غير محددة، مستحيلة،
+
+587
+00:40:13,550 --> 00:40:15,250
+غير محددة، مستحيلة، غير محددة، مستحيلة، غير محددة،
+
+588
+00:40:15,250 --> 00:40:20,830
+مستحيلة، غير محددة، مستحيلة، غير محددة،
+
+589
+00:40:24,060 --> 00:40:28,060
+أنت تلتقي عندك خمسة وعشرين، وتلتقي عندك اثنين،
+
+590
+00:40:28,060 --> 00:40:31,180
+كم أنت تلتقي؟ أنت تلتقي، أنت تلتقي، أنت تلتقي، أنت تلتقي، أنت
+
+591
+00:40:31,180 --> 00:40:31,880
+تلتقي، أنت تلتقي، أنت تلتقي، أنت تلتقي، أنت تلتقي، أنت تلتقي،
+
+592
+00:40:31,880 --> 00:40:33,660
+تلتقي، أنت تلتقي، أنت تلتقي، أنت تلتقي، أنت تلتقي، أنت تلتقي،
+
+593
+00:40:33,660 --> 00:40:34,100
+تلتقي، أنت تلتقي، أنت تلتقي، أنت تلتقي، أنت تلتقي، أنت تلتقي،
+
+594
+00:40:34,100 --> 00:40:35,060
+تلتقي، أنت تلتقي، أنت تلتقي، أنت تلتقي، أنت تلتقي، أنت تلتقي،
+
+595
+00:40:35,060 --> 00:40:44,600
+تلتقي، أنت تلتقي، أنت تلتقي، أنت. هذا هو أكثر مذكرة
+
+596
+00:40:44,600 --> 00:40:51,320
+في التطبيق بين الموظفين والشركة، وبالطبع ستعطيهم
+
+597
+00:40:51,320 --> 00:40:54,520
+إشعارًا. إذا عملت في شركة، تستطيع أن تحصل على إشعار
+
+598
+00:40:54,520 --> 00:40:57,360
+لمدة أسبوع، أو أسبوع، أو أسبوع، أو أسبوع، أو أسبوع، أو
+
+599
+00:40:57,360 --> 00:40:58,180
+أسبوع، أو أسبوع، أو أسبوع، أو أسبوع، أو أسبوع، أو أسبوع،
+
+600
+00:40:58,180 --> 00:40:58,980
+أو أسبوع، أو أسبوع، أو أسبوع، أو أسبوع، أو أسبوع، أو
+
+601
+00:40:58,980 --> 00:40:59,360
+أسبوع، أو أسبوع، أو أسبوع، أو أسبوع، أو أسبوع، أو أسبوع،
+
+602
+00:40:59,360 --> 00:41:02,500
+أو أسبوع، أو أسبوع، أو أسبوع، أو أسبوع، أو أسبوع، أو
+
+603
+00:41:02,500 --> 00:41:06,280
+أو أسبوع، أو أسبوع، أو أسبوع، أو أسبوع، أو أسبوع، أو
+
+604
+00:41:06,280 --> 00:41:12,390
+أسبوع، أو أسبوع. هير، ويستطيع أن يطلع على أحد...
+
+605
+00:41:12,390 --> 00:41:15,410
+ليس بأي وقت، ولكن بالطبع سوف نعطيه ملاحظة... هناك
+
+606
+00:41:15,410 --> 00:41:20,810
+ملاحظة بين الطرفين، وهذه الملاحظة ستكون أكثر من
+
+607
+00:41:20,810 --> 00:41:24,290
+شهر، أو أشهر... يمكن أن يكون أشهر، أو أشهر... في
+
+608
+00:41:24,290 --> 00:41:27,290
+الواقع سأطلب منك أن تغادر الشركة، ولكن سأعطيك
+
+609
+00:41:27,290 --> 00:41:31,270
+ملاحظة شهر، أو أشهر... حسناً؟ بعد أربعة أسابيع، أو بعد ستة
+
+610
+00:41:31,270 --> 00:41:35,650
+أسابيع، لسنا بحاجة إليك أكثر... مثل هذا، إنه بسيط،
+
+611
+00:41:37,130 --> 00:41:41,050
+وخصوصًا إذا كانت الشركة لا تكون لديها فرصة بعد
+
+612
+00:41:41,050 --> 00:41:45,450
+الآن، وليس لديها فرصة، والشركة في هذه الحالة لن
+
+613
+00:41:45,450 --> 00:41:50,730
+تستطيع أن تدفع الناس لأي شيء.
+
+614
+00:41:50,730 --> 00:41:55,030
+مرة أخرى هنا، على الرغم من الحقيقة أننا لدينا بعض
+
+615
+00:41:55,030 --> 00:41:59,250
+التشابهات بين... نحن لدينا تشابهات
+
+667
+00:44:54,430 --> 00:44:57,150
+Additional periodic disclosure number two
+
+668
+00:45:02,790 --> 00:45:06,270
+القانون القيامة، كيف يمكننا أن نتعامل معها، كيف
+
+669
+00:45:06,270 --> 00:45:07,310
+كيف يمكننا أن نتعامل معها، كيف يمكننا أن نتعامل
+
+670
+00:45:07,310 --> 00:45:09,690
+معها، كيف يمكننا أن نتعامل معها، كيف يمكننا أن
+
+671
+00:45:09,690 --> 00:45:10,350
+نتعامل معها، كيف يمكننا أن نتعامل معها، كيف يمكننا
+
+672
+00:45:10,350 --> 00:45:10,610
+أن نتعامل معها، كيف يمكننا أن نتعامل معها، كيف
+
+673
+00:45:10,610 --> 00:45:10,630
+يمكننا أن نتعامل معها، كيف يمكننا أن نتعامل معها،
+
+674
+00:45:10,630 --> 00:45:13,310
+كيف يمكننا أن نتعامل معها، كيف يمكننا أن نتعامل
+
+675
+00:45:13,310 --> 00:45:24,070
+معها، كيف يمكننا أن نتعامل معها،
+
+676
+00:45:24,070 --> 00:45:29,880
+كيف يمكننا مديرين عاملين، مديرين مجلسيين، يجب أن
+
+677
+00:45:29,880 --> 00:45:32,040
+يكون هناك عاملين عاملين عاملين عاملين عاملين
+
+678
+00:45:32,040 --> 00:45:32,740
+عاملين عاملين عاملين عاملين عاملين عاملين عاملين
+
+679
+00:45:32,740 --> 00:45:33,660
+عاملين عاملين عاملين عاملين عاملين عاملين عاملين
+
+680
+00:45:33,660 --> 00:45:34,940
+عاملين عاملين عاملين عاملين عاملين عاملين عاملين
+
+681
+00:45:34,940 --> 00:45:36,960
+عاملين عاملين عاملين عاملين عاملين عاملين عاملين
+
+682
+00:45:36,960 --> 00:45:37,520
+عاملين عاملين عاملين عاملين عاملين عاملين عاملين
+
+683
+00:45:37,520 --> 00:45:37,580
+عاملين عاملين عاملين عاملين عاملين عاملين عاملين
+
+684
+00:45:37,580 --> 00:45:45,760
+عاملين عاملين
+
+685
+00:45:49,490 --> 00:45:54,270
+الشركات لازم تستخدم
+
+686
+00:45:54,270 --> 00:45:57,610
+المال و أساتذة من هذه الشركات لازم تستخدم المال و
+
+687
+00:45:57,610 --> 00:46:01,870
+أساتذة من هذه الشركات لازم تستخدم المال و أساتذة من
+
+688
+00:46:01,870 --> 00:46:04,710
+هذه الشركات لازم تستخدم المال و أساتذة من هذه
+
+689
+00:46:04,710 --> 00:46:04,750
+الشركات لازم تستخدم المال و أساتذة من هذه الشركات
+
+690
+00:46:04,750 --> 00:46:05,090
+المال و أساتذة من هذه الشركات لازم تستخدم المال و
+
+691
+00:46:05,090 --> 00:46:07,230
+أساتذة من هذه الشركات لازم تستخدم المال و أساتذة من
+
+692
+00:46:07,230 --> 00:46:09,430
+هذه الشركات لازم تستخدم المال و أساتذة من هذه
+
+693
+00:46:09,430 --> 00:46:15,530
+الشركات لازم تستخدم المال و أتعامل مع شركات كبيرة
+
+694
+00:46:15,530 --> 00:46:20,510
+تتعامل مع عدد كبير من المال مليون و أحيانا حتى
+
+695
+00:46:20,510 --> 00:46:25,790
+بليون دولار لتعامل مع شركات كبيرة تتعامل مع شركات
+
+696
+00:46:25,790 --> 00:46:27,430
+لتعامل مع شركات كبيرة لتعامل مع شركات كبيرة لتعامل
+
+697
+00:46:27,430 --> 00:46:29,170
+مع شركات كبيرة لتعامل مع شركات كبيرة لتعامل مع
+
+698
+00:46:29,170 --> 00:46:29,810
+شركات كبيرة لتعامل مع شركات كبيرة لتعامل مع شركات
+
+699
+00:46:29,810 --> 00:46:31,190
+كبيرة لتعامل مع شركات كبيرة لتعامل مع شركات كبيرة
+
+700
+00:46:31,190 --> 00:46:38,130
+لتعامل مع شركات كبيرة لتعامل مع
+
+701
+00:46:38,130 --> 00:46:44,160
+شركات كبيرة لمؤسسات ثم سيكون صعب جدًا تدفع المال
+
+702
+00:46:44,160 --> 00:46:52,960
+والتعامل مع التعامل بدون أن يكون هناك عامل إنتاج
+
+703
+00:46:52,960 --> 00:46:56,140
+ومعالجة ومعالجة ومعالجة ومعالجة ومعالجة ومعالجة
+
+704
+00:46:56,140 --> 00:46:56,200
+ومعالجة ومعالجة ومعالجة ومعالجة ومعالجة ومعالجة
+
+705
+00:46:56,200 --> 00:46:57,780
+ومعالجة ومعالجة ومعالجة ومعالجة ومعالجة ومعالجة
+
+706
+00:46:57,780 --> 00:46:59,160
+ومعالجة ومعالجة ومعالجة ومعالجة ومعالجة ومعالجة
+
+707
+00:46:59,160 --> 00:47:07,060
+ومعالجة ومعالجة ومعالجة ومعالجة ومعالجة ومع
+
+708
+00:47:09,650 --> 00:47:10,290
+How many slides?
+
+709
+00:47:18,130 --> 00:47:21,830
+How many presentations do we have? One only. Okay.
+
+710
+00:47:21,830 --> 00:47:25,830
+Good. We still have time, don't worry. We have a
+
+711
+00:47:25,830 --> 00:47:29,910
+mutual benefit. One of the types... One of the
+
+712
+00:47:29,910 --> 00:47:33,870
+types we have, it's called a mutual benefit
+
+713
+00:47:33,870 --> 00:47:38,390
+corporation. This is not... it's not... it's not a
+
+714
+00:47:38,390 --> 00:47:44,010
+profit. وأنها ليست محافظة، إنها ليست مصادفة، إنها
+
+715
+00:47:44,010 --> 00:47:50,070
+مصادفة متعاملة، إنها مصادفة متعاملة، إنها مصادفة
+
+716
+00:47:50,070 --> 00:47:54,130
+متعاملة، إنها مصادفة متعاملة، إنها مصادفة متعاملة،
+
+717
+00:47:54,130 --> 00:48:00,190
+انها مصادفة متعاملة. It's a small unit of people
+
+718
+00:48:00,190 --> 00:48:03,890
+coming together, having benefits from each other,
+
+719
+00:48:03,890 --> 00:48:06,690
+depending on each other. People coming together
+
+720
+00:48:06,690 --> 00:48:10,530
+here having benefit only, only for the member. It's
+
+721
+00:48:10,530 --> 00:48:13,890
+easy, like the club, like having a tennis club for
+
+722
+00:48:13,890 --> 00:48:17,790
+example, having a golf club. We have... we don't have
+
+723
+00:48:17,790 --> 00:48:21,510
+shareholders, we don't have shares. What we have
+
+724
+00:48:21,510 --> 00:48:26,230
+is membership. في عضوية. How many? You have 25 members.
+
+725
+00:48:27,430 --> 00:48:31,050
+أنا أستطيع أن أشتري عضوية يكون 5000 ريال على سبيل
+
+726
+00:48:31,050 --> 00:48:34,910
+المثال، أو ربما أستطيع أن أشتريه بدفع 2000 دولار كل
+
+727
+00:48:34,910 --> 00:48:38,270
+عام. هذا عضوية اشتريتها. أنا أستطيع أن أسحب
+
+728
+00:48:38,270 --> 00:48:46,130
+العضوية. ثم لدينا دليل، الدليل للنظام الداخلي
+
+729
+00:48:46,130 --> 00:48:53,330
+يعطينا كل المعلومات التي نحتاجها. نستطيع أن
+
+730
+00:48:53,330 --> 00:48:57,070
+نستخدمها to be able to function and to make our
+
+731
+00:48:57,070 --> 00:49:02,330
+activities. And at the same time here, that mutual
+
+732
+00:49:02,330 --> 00:49:06,790
+benefit. We call it mutual... mutual benefit. What does
+
+733
+00:49:06,790 --> 00:49:07,010
+it mean?
+
+734
+00:49:10,640 --> 00:49:20,960
+منفعة مشتركة، منفعة
+
+735
+00:49:20,960 --> 00:49:24,040
+مشتركة، منفعة مشتركة، منفعة مشتركة، منفعة مشتركة،
+
+736
+00:49:24,040 --> 00:49:28,000
+منفعة مشتركة، منفعة مشتركة، منفعة مشتركة، منفعة
+
+737
+00:49:28,000 --> 00:49:28,180
+مشتركة، منفعة مشتركة، منفعة مشتركة، منفعة مشتركة،
+
+738
+00:49:28,180 --> 00:49:28,200
+منفعة مشتركة، منفعة مشتركة، منفعة مشتركة، منفعة
+
+739
+00:49:28,200 --> 00:49:31,840
+مشتركة، منفعة مشتركة، منفعة مشتركة، منفعة
+
+740
+00:49:31,840 --> 00:49:35,040
+منفعة
+
+741
+00:49:35,040 --> 00:49:41,460
+مشتركة، هي نسبة كبيرة، ولكنها منفعة. لدينا منفعة هنا، منفعة
+
+742
+00:49:41,460 --> 00:49:45,960
+لشركات أخرى. الآن، في جميع الشركات التي لدينا حتى
+
+743
+00:49:45,960 --> 00:49:49,840
+هذه اللحظة، كانت لديها مصطلح، كما نعود إلى المفهوم
+
+744
+00:49:49,840 --> 00:49:55,440
+الذي لدينا عن الشركات. أقول إن كل شركة لديها ID، كل
+
+745
+00:49:55,440 --> 00:49:59,500
+شركة لديها اسم، كل شركة لديها مصطلح حقيقي. هذا يعني
+
+746
+00:49:59,500 --> 00:50:06,400
+أن لدينا هوية محددة، وأخبرتكم في السابق أن كل شركة
+
+747
+00:50:06,400 --> 00:50:10,280
+ستحصل على قيمة حقوقية بحيث تكون لها عمر مستمر
+
+748
+00:50:10,280 --> 00:50:18,460
+ومسؤولية محددة. ولكن هذه الشركات "ميوتشوال بنيفت" لا
+
+749
+00:50:18,460 --> 00:50:20,520
+يوجد حقوق حقوق حقوق حقوق حقوق حقوق حقوق حقوق حقوق
+
+750
+00:50:20,520 --> 00:50:28,740
+حقوق حقوق
+
+751
+00:50:28,740 --> 00:50:30,680
+حقوق
+
+752
+00:50:34,800 --> 00:50:37,980
+كل الناس اللي كانوا يتكلمون عنها، لديها موقع
+
+753
+00:50:37,980 --> 00:50:45,240
+حقيقي، باستثناء هذا. لماذا؟ مجتمع، موقع حقيقي ليس
+
+754
+00:50:45,240 --> 00:50:49,900
+لديه موقع حقيقي، ليس لديه موقع حقيقي، ليس لديه موقع
+
+755
+00:50:49,900 --> 00:50:50,900
+حقيقي، ليس لديه موقع حقيقي، ليس لديه موقع حقيقي، ليس
+
+756
+00:50:50,900 --> 00:50:55,560
+لديه موقع حقيقي، ليس لديه موقع حقيقي، ليس لديه موقع
+
+757
+00:50:55,560 --> 00:50:57,660
+حقيقي، ليس لديه موقع حقيقي، ليس لديه موقع حقيقي، ليس
+
+758
+00:50:57,660 --> 00:50:58,580
+لديه موقع حقيقي، ليس لديه موقع حقيقي، ليس لديه موقع
+
+759
+00:50:58,580 --> 00:51:01,740
+حقيقي، ليس لديه موقع حقيقي، ليس لديه موقع
+
+760
+00:51:01,740 --> 00:51:07,700
+حقيقي. ليس لديه... العاملين في الشركة، الشركات المالية،
+
+761
+00:51:07,700 --> 00:51:11,680
+سيكون لديها قيمة محددة لأنهم يتعاملون مع مستخدمين،
+
+762
+00:51:11,680 --> 00:51:14,500
+مع مجتمعهم، لكن هؤلاء الناس لا يتعاملون مع أحد
+
+763
+00:51:14,500 --> 00:51:18,700
+آخر، إنها مجتمع صغير، إنها مجتمع قريب، إنهم
+
+764
+00:51:18,700 --> 00:51:20,840
+يتعاملون فقط مع بعضهم البعض. إذا كان لدينا أي
+
+765
+00:51:20,840 --> 00:51:23,260
+مصالح مع بعضنا، ماذا يمكننا أن نفعل؟ إذا كان لدينا
+
+766
+00:51:23,260 --> 00:51:29,300
+سميحة وداليا، فهي لديها مصالح، هل يجب أن نذهب إلى
+
+767
+00:51:29,300 --> 00:51:33,380
+المجتمع لنطلب منه حلول؟ لأ، هذا ليس... هذا مجلس، هذا
+
+768
+00:51:33,380 --> 00:51:36,860
+مفيد متشارك، ثم يجب أن نحلها. يجب أن نذهب للـ buy
+
+769
+00:51:36,860 --> 00:51:43,920
+law، ثم... ثم لا نحتاج أي حاجة للمجتمع، لا يجب أن
+
+770
+00:51:43,920 --> 00:51:47,600
+نتكلم مع المجتمع أو العميل، لا يوجد عميل على أيّة
+
+771
+00:51:47,600 --> 00:51:55,880
+حالة. فأي... أي مشكلة، أي حاجة... والعنف يجب أن يتم حل
+
+772
+00:51:55,880 --> 00:52:01,160
+في شركة المنفعة المشتركة، وهذا السبب ليس هناك
+
+773
+00:52:01,160 --> 00:52:05,420
+احتجاج. لديها مصطلح حقيقي، ويمكن أن يكون المنفعة تعمل
+
+774
+00:52:05,420 --> 00:52:09,200
+فقط لشركات مجتمعها، ويمكن أن يعملوا مع بعضهم البعض،
+
+775
+00:52:09,200 --> 00:52:12,880
+أحد يمكن أن يعمل داخلها. كما نرى أن هناك شيء يسمى
+
+776
+00:52:12,880 --> 00:52:17,260
+consumer cooperative, consumer cooperative. لاحقًا، أو
+
+777
+00:52:17,260 --> 00:52:22,510
+ليس الآن. You can be a member, you can be a customer,
+
+778
+00:52:22,510 --> 00:52:28,070
+you can be an employee at the same time. This is in
+
+779
+00:52:28,070 --> 00:52:30,410
+a consumer cooperative. Once we get to that point...
+
+780
+00:52:30,410 --> 00:52:33,570
+multinational
+
+781
+00:52:33,570 --> 00:52:42,490
+corporation. نقطة، ومش حنين. I can't hear you, we're
+
+782
+00:52:42,490 --> 00:52:44,110
+still behind schedule.
+
+783
+00:52:46,540 --> 00:52:53,940
+multinational. بس بس بس بس بس بس بس بس بس بس بس
+
+784
+00:52:53,940 --> 00:52:57,480
+بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس
+
+785
+00:52:57,480 --> 00:52:58,520
+بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس
+
+786
+00:52:58,520 --> 00:53:05,000
+بس بس بس بس بس بس بس بس بس بس بس
+
+787
+00:53:05,000 --> 00:53:16,080
+بس
+
+788
+00:53:17,470 --> 00:53:23,090
+بتستغل خارج الحاجات الدولية لكي تحصل على مواقع
+
+789
+00:53:23,090 --> 00:53:30,650
+مميزة، ومميزة من قوة، وإنفلونْس في الروحانية
+
+790
+00:53:30,650 --> 00:53:36,790
+ومجتمعها، ومجتمعها، ومميزة من قوة
+
+791
+00:53:36,790 --> 00:53:37,090
+ومميزة من قوة، ومميزة من قوة، ومميزة من قوة، ومميزة
+
+792
+00:53:37,090 --> 00:53:38,430
+من قوة، ومميزة من قوة، ومميزة من قوة، ومميزة من قوة
+
+793
+00:53:38,430 --> 00:53:38,530
+من قوة، ومميزة من قوة، ومميزة من قوة، ومميزة من قوة
+
+794
+00:53:38,530 --> 00:53:45,590
+ومميزة من قوة... يمكنك تسميته مرسيدس، بي ام دبليو، ديل، سوني،
+
+795
+00:53:45,590 --> 00:53:49,090
+حسب، سي بانك. مدينة مدينة مدينة مدينة مدينة مدينة
+
+796
+00:53:49,090 --> 00:53:50,190
+مدينة مدينة مدينة مدينة مدينة مدينة مدينة مدينة
+
+797
+00:53:50,190 --> 00:53:50,330
+مدينة مدينة مدينة مدينة مدينة مدينة مدينة مدينة
+
+798
+00:53:50,330 --> 00:53:52,890
+مدينة مدينة مدينة مدينة مدينة مدينة مدينة مدينة
+
+799
+00:53:52,890 --> 00:53:52,990
+مدينة مدينة مدينة مدينة مدينة مدينة مدينة مدينة
+
+800
+00:53:52,990 --> 00:53:55,050
+مدينة مدينة مدينة مدينة مدينة مدينة مدينة مدينة
+
+801
+00:53:55,050 --> 00:54:02,210
+مدينة
+
+802
+00:54:02,210 --> 00:54:07,950
+مدينة
+
+803
+00:54:07,950 --> 00:54:15,090
+100 قطعة، 200 قطعة، 500 قطعة، في كل مصر، في كل بلد.
+
+804
+00:54:15,090 --> 00:54:17,430
+أحيانًا الشركة، مشاركة مشاركة مشاركة مشاركة
+
+805
+00:54:17,430 --> 00:54:18,990
+المشاركة المشاركة المشاركة المشاركة المشاركة
+
+806
+00:54:18,990 --> 00:54:20,690
+المشاركة المشاركة المشاركة المشاركة المشاركة
+
+807
+00:54:20,690 --> 00:54:21,170
+المشاركة المشاركة المشاركة المشاركة المشاركة
+
+808
+00:54:21,170 --> 00:54:21,610
+المشاركة المشاركة المشاركة المشاركة المشاركة
+
+809
+00:54:21,610 --> 00:54:22,190
+المشاركة المشاركة المشاركة المشاركة المشاركة
+
+810
+00:54:22,190 --> 00:54:22,850
+المشاركة المشاركة المشاركة المشاركة المشاركة
+
+811
+00:54:22,850 --> 00:54:38,250
+المشاركة المشاركة المشاركة المشاركة المشار
+
+812
+00:54:39,920 --> 00:54:45,780
+طبعًا، شخص يأخذ المسؤولية، ويكون شخص مثلاً في كل بلد
+
+813
+00:54:45,780 --> 00:54:51,500
+سيكون لديها مجلس رئيسي، وعامة، وعامة في المجلس
+
+814
+00:54:51,500 --> 00:54:57,740
+الرئيس. يكون مجلس مجلس مجلس مجلس مجلس مجلس مجلس
+
+815
+00:54:57,740 --> 00:54:59,080
+مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس
+
+816
+00:54:59,080 --> 00:54:59,660
+مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس
+
+817
+00:54:59,660 --> 00:55:07,520
+مجلس مجلس مجلس مج
+
+818
+00:55:08,510 --> 00:55:13,610
+The culture of this company, like
+
+819
+00:55:13,610 --> 00:55:19,490
+for example, when you talk about McDonald's, it's
+
+820
+00:55:19,490 --> 00:55:24,250
+the same food style. KFC, it's the same food style.
+
+821
+00:55:24,250 --> 00:55:30,190
+And Coca-Cola... those companies have the same brand, same
+
+822
+00:55:30,190 --> 00:55:33,770
+name, same size, same shape, they taste the same,
+
+823
+00:55:34,030 --> 00:55:36,850
+this is the culture of that company, and this is
+
+824
+00:55:36,850 --> 00:55:40,950
+what can unify all those branches all over the
+
+825
+00:55:40,950 --> 00:55:43,950
+world, despite the overlapping. يعني في تداخل بين
+
+826
+00:55:43,950 --> 00:55:47,950
+الصلاحيات، but still we have the same culture
+
+827
+00:55:47,950 --> 00:55:55,790
+existing everywhere. Our
+
+828
+00:55:55,790 --> 00:55:56,290
+last slide.
+
+829
+00:56:00,340 --> 00:56:02,400
+Tax. What do you think? How much money should the
+
+830
+00:56:02,400 --> 00:56:03,240
+company pay in tax?
+
+831
+00:56:06,800 --> 00:56:10,520
+How many
+
+832
+00:56:10,520 --> 00:56:13,020
+times should we pay tax for the same amount of
+
+833
+00:56:13,020 --> 00:56:13,200
+money?
+
+834
+00:56:17,160 --> 00:56:20,140
+عن نفس المال الذي نحصل عليه... عن نفس المال الذي
+
+835
+00:56:20,140 --> 00:56:21,780
+نحصل عليه... عن نفس المال الذي نحصل عليه... عن نفس
+
+836
+00:56:21,780 --> 00:56:22,120
+المال الذي نحصل عليه... عن نفس المال الذي نحصل عليه
+
+837
+00:56:22,120 --> 00:56:24,680
+...عن نفس المال الذي نحصل عليه... عن نفس المال الذي
+
+838
+00:56:24,680 --> 00:56:26,060
+نحصل عليه... عن نفس المال الذي نحصل عليه... عن نفس
+
+839
+00:56:26,060 --> 00:56:28,200
+المال الذي نحصل عليه... عن نفس المال الذي نحصل عليه
+
+840
+00:56:28,200 --> 00:56:28,880
+...عن نفس المال الذي نحصل عليه... عن نفس المال الذي
+
+841
+00:56:28,880 --> 00:56:31,720
+نحصل عليه... عن نفس المال الذي نحصل عليه
+
+842
+00:56:31,720 --> 00:56:37,860
+...عن نفس
+
+843
+00:56:37,860 --> 00:56:38,680
+المال الذي نحصل عليه...
+
+844
+00:56:42,770 --> 00:56:46,950
+وهنا لدينا أيضًا income tax، personal income tax،
+
+845
+00:56:46,950 --> 00:56:52,230
+وcompany income tax. لدينا شيء يسمى double
+
+846
+00:56:52,230 --> 00:56:59,900
+taxation. هذا يحدث بخطأ. Double taxation يحدث بخطأ. لا
+
+847
+00:56:59,900 --> 0
+
+889
+00:59:34,650 --> 00:59:38,990
+بتحفظ المالية
+
+890
+00:59:40,790 --> 00:59:42,830
+أنا أعني أن هذا ما يزال مقارنة بين العديد من
+
+891
+00:59:42,830 --> 00:59:46,650
+البلدان وبعضها لديها حلول وبعضها لا لديها حلول
+
+892
+00:59:46,650 --> 00:59:51,590
+لدينا لا لدينا .. لدينا مجموعة مرتفعة
+
+893
+00:59:51,590 --> 00:59:52,070
+مرتفعة
+
+894
+00:59:52,070 --> 00:59:52,230
+مرتفعة
+
+895
+00:59:52,230 --> 00:59:52,850
+مرتفعة
+
+896
+00:59:52,850 --> 00:59:54,730
+مرتفعة
+
+897
+00:59:54,730 --> 00:59:54,790
+مرتفعة
+
+898
+00:59:54,790 --> 01:00:01,790
+مرتفعة  مال الشركة دعنا
+
+899
+01:00:01,790 --> 01:00:05,550
+نقول أن الشركة تدفع 5 مليون باوند ثم الشركة ستدفع
+
+900
+01:00:05,550 --> 01:00:06,850
+المال الخاص
+
+901
+01:00:06,850 --> 01:00:08,890
+بالمال الخاص
+
+902
+01:00:08,890 --> 01:00:08,910
+بالمال الخاص
+
+903
+01:00:08,910 --> 01:00:10,250
+الخاص
+
+904
+01:00:10,250 --> 01:00:11,550
+بالمال الخاص
+
+905
+01:00:11,550 --> 01:00:11,630
+الخاص
+
+906
+01:00:11,630 --> 01:00:16,730
+بالمال الخاص
+
+907
+01:00:16,730 --> 01:00:20,410
+الخاص بالمال الخ
+
+908
+01:00:24,140 --> 01:00:27,500
+أنت تدفع المال مرتين أعني بخطأ يمكن أن يحدث في بعض
+
+909
+01:00:27,500 --> 01:00:32,120
+الوقت تدفع المال .. تدفع المال على الطعام نفسه
+
+910
+01:00:32,120 --> 01:00:36,760
+عندما تشتغل الطعام تدفع المال وهذا موجود مع السعر
+
+911
+01:00:36,760 --> 01:00:42,360
+نفسه ومرة أخرى يمكن أن يضيفوا المال بعد أن تدفع
+
+912
+01:00:42,360 --> 01:00:46,820
+المال وهذا ليس صحيح والمستخدم يدفع كل شيء في
+
+913
+01:00:46,820 --> 01:00:52,320
+نهاية اليوم المستخدم يأخذ كل هذا ويدفع الفرص بين
+
+914
+01:00:53,130 --> 01:00:55,810
+the tax we paid and the tax we supposed to pay
+
+915
+01:00:55,810 --> 01:00:59,410
+anyway thanks for your time and see you next week
diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/ZTV3yXlzw3A_raw.srt b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/ZTV3yXlzw3A_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..643004f1f05ae9043e5da3f7fdf80b7720ffd7d6
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/ZTV3yXlzw3A_raw.srt
@@ -0,0 +1,3616 @@
+1
+00:00:12,660 --> 00:00:15,960
+السلام عليكم as you can see that we still haven't
+
+2
+00:00:15,960 --> 00:00:18,420
+finished yet in this chapter companies and
+
+3
+00:00:18,420 --> 00:00:22,140
+corporations one
+
+4
+00:00:22,140 --> 00:00:27,040
+of the points I would focus on now for the next
+
+5
+00:00:27,040 --> 00:00:31,900
+few minutes is a criticismof companies and
+
+6
+00:00:31,900 --> 00:00:35,640
+specifically for corporations there were some
+
+7
+00:00:35,640 --> 00:00:38,680
+schoolers and there are some schoolers in
+
+8
+00:00:38,680 --> 00:00:41,640
+commercial law who criticized the idea of
+
+9
+00:00:41,640 --> 00:00:47,680
+corporations one of them is Adam Smith and Adam
+
+10
+00:00:47,680 --> 00:00:51,480
+Smith is one of the famous names in economics and
+
+11
+00:00:51,480 --> 00:00:58,340
+I guess that you know Adam Smith, do you?أحد أفضل
+
+12
+00:00:58,340 --> 00:01:03,160
+أسماء في الاقتصاد، Adam Smith في السنة التاسعة
+
+13
+00:01:03,160 --> 00:01:11,260
+عشرة عامة اعتبار الفكرة، الفكرة من المجتمع وكان
+
+14
+00:01:11,260 --> 00:01:16,120
+يعتبر أكتر فكرة الانقلاق بين المالكين والمديرين
+
+15
+00:01:16,120 --> 00:01:19,600
+كما كان لنا الأسبوع الماضي والأسبوع الماضي قبل ذلك
+
+16
+00:01:19,600 --> 00:01:25,120
+قلت عدة مرات عدة مرات أننالدينا مصادر الشركات و
+
+17
+00:01:25,120 --> 00:01:28,280
+لدينا الناس اللي يتحكمون عليها و الناس اللي
+
+18
+00:01:28,280 --> 00:01:31,540
+يتحكمون عليها نحن نسميهم الرئيس أو مصادر الرئيسين
+
+19
+00:01:31,540 --> 00:01:35,140
+هذا هو السبب لدينا الفرصة بينهم في شركات مصادر
+
+20
+00:01:35,140 --> 00:01:38,020
+الشركات شركات مصادر الشركات يعني شركات مصادر
+
+21
+00:01:38,020 --> 00:01:43,440
+الشركات لدينا أساسين أساسين رقم واحد في الأساس
+
+22
+00:01:43,440 --> 00:01:46,900
+لدينا المصادر الشركات والمصادر الشركات و رقم اثنان
+
+23
+00:01:46,900 --> 00:01:52,790
+في الأعلى لدينا الرئيس لدينا مصادر الرئيسفي الواقع
+
+24
+00:01:52,790 --> 00:01:55,470
+انهم يستطيعون تحكم الشركة و يستطيعون أن يأخذ
+
+25
+00:01:55,470 --> 00:02:01,030
+المساعدة كما ترون هنا مديرين من هذه الشركات يكونوا
+
+26
+00:02:01,030 --> 00:02:07,030
+مديرين ليس هنا ليس الناس الذين يمتلكونها يمكنهم أن
+
+27
+00:02:07,030 --> 00:02:09,970
+يمتلكوا بعض المشارعات من هذه الشركات و يمكنهم أن
+
+28
+00:02:09,970 --> 00:02:12,990
+يمتلكوا بعض المشارعات من هذه الشركات ولكن هذا لا
+
+29
+00:02:12,990 --> 00:02:20,270
+يعني انهم يمتلكوا كل شيء يمتلكوا جزء من هذه الشركة
+
+30
+00:02:20,270 --> 00:02:23,600
+ولكنهم يسيطرونهم يستطيعون أن يأخذ القرار على
+
+31
+00:02:23,600 --> 00:02:29,620
+محافظة المشاركين هذا سيجعل بعض الوقت فرق كبير بين
+
+32
+00:02:29,620 --> 00:02:37,280
+المشاركين والمديرين هذا جعل Adam Smith يؤمن أن
+
+33
+00:02:37,280 --> 00:02:40,580
+أولئك الناس في مجلس التنظيم يمكنهم أن يسيطروا عدد
+
+34
+00:02:40,580 --> 00:02:47,440
+صغير من المديرين لكن في نفس الوقت لن يشاهدوا أو
+
+35
+00:02:47,440 --> 00:02:54,840
+يشاهدواالشركة كما لو كانت شركتها الخاصة عالم سميث
+
+36
+00:02:54,840 --> 00:03:01,220
+يؤمن أن هناك نجلجانس نجلجانس الناس لايعرفون كثير
+
+37
+00:03:01,220 --> 00:03:05,640
+عن الشركة لأنها ليست شركتهم الخاصة على الرغم من
+
+38
+00:03:05,640 --> 00:03:10,660
+الحقيقة أنهم وضعوا بعض المال من شركتهم الخاصة ولكن
+
+39
+00:03:10,660 --> 00:03:17,430
+هؤلاء الناسلا يصدروا أن هذا مجرد عملهم فقط لذلك لن
+
+40
+00:03:17,430 --> 00:03:22,950
+ينظروا إلى هذا العمل كما لو كانت عملهم خاصة فهو
+
+41
+00:03:22,950 --> 00:03:26,190
+مفتوح للجميع أحد يستطيع أن يختار نفسه أحد يستطيع
+
+42
+00:03:26,190 --> 00:03:30,110
+أن يركض لطريقة مثل هذه لكي يكون رئيس، لكي يكون
+
+43
+00:03:30,110 --> 00:03:34,230
+رئيس ولكن في نهاية اليوم لدينا عدد صغير من الناس
+
+44
+00:03:34,230 --> 00:03:37,810
+اللي يسمونهم مجلس الرئيسين يستطيعون أن يسيطروا على
+
+45
+00:03:37,810 --> 00:03:43,410
+كل شيء ولكن بقية المستخدمينسوف لا يدفعوا المال فقط
+
+46
+00:03:43,410 --> 00:03:48,910
+و يتمكنوا من الحصول على مقابلات عامة نحن لدينا
+
+47
+00:03:48,910 --> 00:03:53,830
+مجلس عام جمهوري نسميها جمعية عامة الجمعية العامة
+
+48
+00:03:53,830 --> 00:03:58,450
+جمعية عامة في الواقع لدينا ألف شركات لا يستطيعوا
+
+49
+00:03:58,450 --> 00:04:00,570
+أن تحكموها لا يستطيعوا أن تحكموها لكنهم يستطيعون
+
+50
+00:04:00,570 --> 00:04:03,350
+أن يحكموها لكن الناس الوحيدين اللي يستطيعوا أن
+
+51
+00:04:03,350 --> 00:04:08,470
+يحكموها حقًا هم الرئيسين هذا سيؤدي في بعض الأحيان
+
+52
+00:04:08,470 --> 00:04:13,630
+إلى نجلجةwhich can sometimes prevail .. prevail ..
+
+53
+00:04:13,630 --> 00:04:18,710
+prevail ينتشر Negligence .. what's negligence? Do
+
+54
+00:04:18,710 --> 00:04:23,190
+you know it؟ احمال .. this negligence by the board
+
+55
+00:04:23,190 --> 00:04:27,290
+of directors .. this can prevail on many affairs
+
+56
+00:04:27,290 --> 00:04:30,450
+.. in many issues listen if you don't understand
+
+57
+00:04:30,450 --> 00:04:34,230
+some .. some terms just you can ask me .. you can
+
+58
+00:04:34,230 --> 00:04:36,310
+stop me and say well I don't understand this word
+
+59
+00:04:36,730 --> 00:04:39,470
+just don't keep me going and saying many things
+
+60
+00:04:39,470 --> 00:04:42,450
+and at the end of the day you might not understand
+
+61
+00:04:42,450 --> 00:04:45,810
+what I'm saying just whenever you feel that it's a
+
+62
+00:04:45,810 --> 00:04:47,630
+little bit difficult and there's some words you
+
+63
+00:04:47,630 --> 00:04:49,890
+don't understand you cannot stop me and say well
+
+64
+00:04:49,890 --> 00:04:56,330
+this point I don't get it okay that
+
+65
+00:04:56,330 --> 00:05:00,240
+was not only Adam Smithأيضًا ستجد في المقالات
+
+66
+00:05:00,240 --> 00:05:03,260
+التالية، هناك بعض المدرسين الذين يتكلمون عن فكرة
+
+67
+00:05:03,260 --> 00:05:07,520
+الشركات، الشركات Adam Smith في السنة الثالثة عشر
+
+68
+00:05:07,520 --> 00:05:11,740
+كان يتكلم عن شركات مجتمعية وليس الأن، كان يتكلم عن
+
+69
+00:05:11,740 --> 00:05:18,800
+شركات وشركات حوالي 150، 160 عامًا، وفي ذلك الوقت
+
+70
+00:05:20,420 --> 00:05:26,340
+الشركات تم خلقها من رئيس إنقلاب بشركة خاصة ولكن
+
+71
+00:05:26,340 --> 00:05:34,600
+لدينا في ذلك الوقت فساد و رشوة
+
+72
+00:05:34,600 --> 00:05:37,040
+و فساد
+
+73
+00:05:38,110 --> 00:05:43,850
+هذه النقطة كانت توجد في الشركات قبل وقت طويل
+
+74
+00:05:43,850 --> 00:05:48,130
+لماذا؟ لأن لدينا نفس الوضع، نفس الحالة في التي
+
+75
+00:05:48,130 --> 00:05:52,430
+لدينا بعض المديرين لا ينظروا جيدًا إلى هذه
+
+76
+00:05:52,430 --> 00:05:58,790
+الشركات، لهم هي عمل، هي موقع، ليس مقدسة، ليس
+
+77
+00:05:58,790 --> 00:06:02,970
+أموالهم التي انتجوها، هي أموال انتجتها من أخرين،
+
+78
+00:06:02,970 --> 00:06:08,220
+ولكن هؤلاء الناس ينظروا إلى تلك الشركةوهو السبب في
+
+79
+00:06:08,220 --> 00:06:11,860
+بعض الأحيان أن مديرين مثلها، مديرين محافظين على
+
+80
+00:06:11,860 --> 00:06:17,840
+الانقلاب، انقلاب المحافظة، لم يريدوا أن يكونوا
+
+81
+00:06:17,840 --> 00:06:23,340
+مواجهين لأي شخص ونحن
+
+82
+00:06:23,340 --> 00:06:29,640
+لدينا بعض الأمثلة اليوم، إذا تنظر إلى 2008، ما حدث
+
+83
+00:06:29,640 --> 00:06:33,720
+في الولايات المتحدة؟وبعض البلدان الأوروبية اليوم
+
+84
+00:06:33,720 --> 00:06:39,160
+ستجد الكثير من الشركات تعلن عن مغامرة الكثير من
+
+85
+00:06:39,160 --> 00:06:46,800
+الشركات اتفجروا وانتهتوا حياتهم لأن في الكثير من
+
+86
+00:06:46,800 --> 00:06:51,540
+الحالات كان هناك خطأ ليس فقط خطأ خطأ او استخدام او
+
+87
+00:06:51,540 --> 00:06:56,300
+استخدام من رئيس الشركات من رئيس الشركات من رئيس
+
+88
+00:06:56,300 --> 00:06:57,940
+الشركات من رئيس الشركات من رئيس الشركات من رئيس
+
+89
+00:06:57,940 --> 00:06:59,300
+الشركات من رئيس الشركات من رئيس الشركات من رئيس
+
+90
+00:06:59,300 --> 00:06:59,360
+الشركات من رئيس الشركات من رئيس الشركات من رئيس
+
+91
+00:06:59,360 --> 00:06:59,920
+الشركات من رئيس الشركات من رئيس الشركات من رئيس
+
+92
+00:06:59,920 --> 00:07:04,510
+الشركات من رئيس الشركات من رئهؤلاء الرئيسين كانوا
+
+93
+00:07:04,510 --> 00:07:10,290
+يفعلون أفضل من أجله لإيجار نفسهم وليس للشركة لأنها
+
+94
+00:07:10,290 --> 00:07:16,910
+موقع ومميزة ومال يمكنهم الحصول عليه وبعضهم جعلوا
+
+95
+00:07:16,910 --> 00:07:21,910
+الكثير من المال على تكلفة الشركات وعلى تكلفة
+
+96
+00:07:21,910 --> 00:07:27,180
+الشركة ويحصلوا على كل شيء لأنفسهمالتعامل مع بعض
+
+97
+00:07:27,180 --> 00:07:30,700
+الشركات، بعضهم كانوا يحصلون على عيون، عيون فقط،
+
+98
+00:07:30,700 --> 00:07:35,340
+مليون دولار في السنة، عيون أعظم مدفعة، أعظم،
+
+99
+00:07:35,340 --> 00:07:40,880
+لأولئك الناس اللي يعملون في شركات كبيرة، في شركات
+
+100
+00:07:40,880 --> 00:07:45,300
+مجتمعية، و هم في موقعات أكبر، بعضهم يحصلون على 5
+
+101
+00:07:45,300 --> 00:07:49,320
+مليون، 10 مليون دولار في السنة، عيون بعضهم يحصلون
+
+102
+00:07:49,320 --> 00:07:55,730
+على بوناس، بوناس فقط، مليون دولاروهذا سيقوم
+
+103
+00:07:55,730 --> 00:08:03,270
+بالعبادة ومحرومة ومحرومة الموقف اللي لديه ومحرومة
+
+104
+00:08:03,270 --> 00:08:06,230
+الوظيفة، وهذا أخيرًا أخيرًا أخيرًا أخيرًا أخيرًا
+
+105
+00:08:06,230 --> 00:08:07,610
+أخيرًا أخيرًا أخيرًا أخيرًا أخيرًا أخيرًا أخيرًا
+
+106
+00:08:07,610 --> 00:08:08,410
+أخيرًا أخيرًا أخيرًا أخيرًا أخيرًا أخيرًا أخيرًا
+
+107
+00:08:08,410 --> 00:08:09,330
+أخيرًا أخيرًا أخيرًا أخيرًا أخيرًا أخيرًا أخيرًا
+
+108
+00:08:09,330 --> 00:08:12,390
+أخيرًا أخيرًا أخيرًا أخيرًا أخيرًا أخيرًا أخيرًا
+
+109
+00:08:12,390 --> 00:08:17,310
+أخيرًا أخيرًا أخاليوم لدينا نفس الوضع مع الشركات
+
+110
+00:08:17,310 --> 00:08:22,430
+وقال انه لم يعتبر جوانتي ستوك كمبيونات جوانتي ستوك
+
+111
+00:08:22,430 --> 00:08:28,850
+يعني شركة جوانتي ستوك كمبيونات لم يعتبرهم صادقين
+
+112
+00:08:28,850 --> 00:08:33,790
+ليس جوانتي ستوك كمبيونات ولكنه لم يعتبر المديرين
+
+113
+00:08:33,790 --> 00:08:39,430
+المعاملين المديرين صادقين ليس صادقين ليس صادقين
+
+114
+00:08:39,430 --> 00:08:42,670
+ليس صادقين ليس صادقين ليس صادقين ليس صادقين ليس
+
+115
+00:08:42,670 --> 00:08:42,670
+صادقين ليس صادقين ليس صادقين ليس صادقين ليس صادقين
+
+116
+00:08:42,670 --> 00:08:42,670
+ليس صادقين ليس صادقين ليس صادقين ليس صادقين ليس
+
+117
+00:08:42,670 --> 00:08:47,270
+صادقين ليس صادقين ليس صادقين ليجوال باكن هو .. هو
+
+118
+00:08:47,270 --> 00:08:51,970
+صاحب القانون في عالم British Columbia British
+
+119
+00:08:51,970 --> 00:08:55,010
+Columbia واحدة من أفضل العلماء في العالم، واحدة من
+
+120
+00:08:55,010 --> 00:08:59,010
+الأفضل، واحدة من أعلى مجالات العلماء في العالم،
+
+121
+00:08:59,010 --> 00:09:03,150
+اسمها British Columbia، أعتقد أنها كندا، في كندا،
+
+122
+00:09:03,150 --> 00:09:10,010
+وجوال باكن تعلم القانون في تلك العلمة كواحد من
+
+123
+00:09:10,010 --> 00:09:15,200
+الكتابين، واحد من المدرسين في القانون قالhe said
+
+124
+00:09:15,200 --> 00:09:20,460
+corporations are psychopaths psychopathic here he
+
+125
+00:09:20,460 --> 00:09:23,840
+is a psychopathic creature and what does it mean
+
+126
+00:09:23,840 --> 00:09:26,500
+psychopathic here look sometimes we say about a
+
+127
+00:09:26,500 --> 00:09:30,600
+human being somebody is a psychopath what does it
+
+128
+00:09:30,600 --> 00:09:34,480
+mean go
+
+129
+00:09:34,480 --> 00:09:43,950
+on I'm listening to you no comment at allهل تفهم
+
+130
+00:09:43,950 --> 00:09:50,350
+ما أقوله في الوضع؟ لا؟ نعم؟ نعم أو لا؟ حسنا، حسنا،
+
+131
+00:09:50,350 --> 00:09:55,250
+عندما يقول هذا عن شخص هو سيكوبات، يعني أن هذا
+
+132
+00:09:55,250 --> 00:09:59,970
+الشخص ليس ثابت في عقله، لا يستطيع أن يكون مستقل مع
+
+133
+00:09:59,970 --> 00:10:04,470
+نفسه، لا يستطيع أن يقرر قرارات أخيرة، نفس الشيء مع
+
+134
+00:10:04,470 --> 00:10:08,050
+الكامبوليات، يقول أن هؤلاء الكامبولياتهؤلاء
+
+135
+00:10:08,050 --> 00:10:10,550
+الشركات لا يستطيعون أن تعملوا قرارات محددة في بعض
+
+136
+00:10:10,550 --> 00:10:13,730
+الأحيان، لا يستطيعون أن يكونوا مستقلين، لا
+
+137
+00:10:13,730 --> 00:10:16,170
+يستطيعون أن يكونوا مخلصين، لا يستطيعون أن يكونوا
+
+138
+00:10:16,170 --> 00:10:17,110
+مخلصين، لا يستطيعون أن تكونوا مخلصين، لا يستطيعون
+
+139
+00:10:17,110 --> 00:10:18,090
+أن تكونوا مخلصين، لا يستطيعون أن تكونوا مخلصين، لا
+
+140
+00:10:18,090 --> 00:10:19,190
+يستطيعون أن تكونوا مخلصين، لا يستطيعون أن تكونوا
+
+141
+00:10:19,190 --> 00:10:21,250
+مخلصين، لا يستطيعون أن تكونوا مخلصين، لا يستطيعون
+
+142
+00:10:21,250 --> 00:10:27,430
+أن تكونوا مخلصين، لا يستطيعون أن تكونوا مخلصين، لا
+
+143
+00:10:27,430 --> 00:10:29,030
+يستطيعون أن تكونوا مخلصين
+
+144
+00:10:37,100 --> 00:10:41,100
+الشركات قد تكون في نفس الوقت أو في نفس الموقع،
+
+145
+00:10:41,100 --> 00:10:44,320
+يمكن أن يكونوا شركات مجانية، مجانية فقط تحاولون أن
+
+146
+00:10:44,320 --> 00:10:46,820
+تجعلوا المال و ليسوا قادرين على إصلاح نفسهم في
+
+147
+00:10:46,820 --> 00:10:51,420
+السوق، و هذا هو نظره نفسه، يؤمنون أن الشركات يمكن
+
+148
+00:10:51,420 --> 00:10:57,480
+أن تكونوا سيكوبات، مخلوقات مجانية، ليس فقط هؤلاء
+
+149
+00:10:57,480 --> 00:11:01,280
+الاثنين المدرسين، لدينا في أضافة إلى هذا نوم
+
+150
+00:11:01,280 --> 00:11:06,800
+تشومسكيpsychopath شخص مقتربش .. شخص مقترب .. مقترب
+
+151
+00:11:06,800 --> 00:11:11,660
+مشوّش نعم
+
+152
+00:11:11,660 --> 00:11:17,020
+نعوم .. there's somebody called نعوم تشومسكي did
+
+153
+00:11:17,020 --> 00:11:22,660
+you hear of this name؟ no؟ نعوم تشومسكي، حنين do
+
+154
+00:11:22,660 --> 00:11:26,760
+you have any idea about him؟ famous name did you
+
+155
+00:11:26,760 --> 00:11:31,900
+hear anything about إدوارد سعيد؟ who was إدوارد
+
+156
+00:11:31,900 --> 00:11:32,420
+سعيد؟
+
+157
+00:11:35,560 --> 00:11:38,980
+one of the best .. I guess he was number one in
+
+158
+00:11:38,980 --> 00:11:41,460
+the world .. he was the best .. he was .. he was
+
+159
+00:11:41,460 --> 00:11:44,580
+the best .. when he passed away .. I think now one
+
+160
+00:11:44,580 --> 00:11:47,380
+of the best in the world is .. now one of the best
+
+161
+00:11:47,380 --> 00:11:53,320
+in the world is Naomi Chomsky .. Naomi is a Jew ..
+
+162
+00:11:53,320 --> 00:11:57,500
+Jew living in United States .. Jew .. يهولية ..
+
+163
+00:11:57,500 --> 00:12:01,360
+living in the states .. and he is a linguist ..
+
+164
+00:12:01,360 --> 00:12:06,250
+but ..هو واحد من أفضل الكتابين بالنسبة لي هو واحد
+
+165
+00:12:06,250 --> 00:12:11,870
+من الأفضل في زي وقته اليوم لديه الكثير من الحلقات
+
+166
+00:12:11,870 --> 00:12:17,350
+و الكتب عن فلسطين و الفلسطينيين و هو يدفع القضية
+
+167
+00:12:17,350 --> 00:12:21,010
+الفلسطينية انا رأيت الكثير من حلقاته كيف يدفع
+
+168
+00:12:21,010 --> 00:12:24,710
+القضية الفلسطينية انه يدفع القضية الفلسطينية و هو
+
+169
+00:12:24,710 --> 00:12:29,690
+يكتب في السياسة و في الكتابة عندما تقول انه لغوست
+
+170
+00:12:29,690 --> 00:12:36,150
+ما يعني لغوست؟متخصص في علم اللغات متخصص لغة
+
+171
+00:12:36,150 --> 00:12:40,090
+linguist I described here and he did speak he did
+
+172
+00:12:40,090 --> 00:12:43,070
+speak about corporations he did not like the idea
+
+173
+00:12:43,070 --> 00:12:49,090
+of corporations he resembled corporations as as a
+
+174
+00:12:49,090 --> 00:12:53,390
+fascist fascist system what fascist فاشية do you
+
+175
+00:12:53,390 --> 00:13:00,710
+know it okay what does it mean fascism fascism you
+
+176
+00:13:00,710 --> 00:13:05,110
+have a small number of peopleمجموعة صغيرة من الناس
+
+177
+00:13:05,110 --> 00:13:11,510
+تتحكم في كل شيء هنا، لديه تحكم قوي في الأعلى
+
+178
+00:13:11,510 --> 00:13:14,610
+وإبادة
+
+179
+00:13:14,610 --> 00:13:17,670
+مستعمرة في
+
+180
+00:13:17,670 --> 00:13:23,090
+كل مستوى، يعني الشركة تتحكم في التحكم القوي في
+
+181
+00:13:23,090 --> 00:13:28,150
+الأعلىمديرين يتحكمون في قوة الحكومة ولكن في الأسفل
+
+182
+00:13:28,150 --> 00:13:32,070
+لدينا أعلى مستوى في الواقع لدينا شركات مستخدمين كل
+
+183
+00:13:32,070 --> 00:13:38,730
+ما يجب أن تفعله هو إبداع و هو قال هذا مثل الفاشية
+
+184
+00:13:38,730 --> 00:13:44,030
+فشية فشية لدينا فقط عدد صغير من الناس فقط عدد صغير
+
+185
+00:13:44,030 --> 00:13:49,250
+منهم هذه المجالة التي تحكم الجميع في البلد الجميع
+
+186
+00:13:50,000 --> 00:13:53,780
+what he said he added saying that was that was
+
+187
+00:13:53,780 --> 00:13:56,780
+Naam Chomsky what did he say can you read it أهوة
+
+188
+00:13:56,780 --> 00:14:00,640
+eliminated
+
+189
+00:14:00,640 --> 00:14:12,260
+eliminated ultimately
+
+190
+00:14:12,260 --> 00:14:17,780
+I
+
+191
+00:14:20,570 --> 00:14:26,410
+أعتقد أنك تفهم الفرق بين الركزية و الانتصاف، أليس
+
+192
+00:14:26,410 --> 00:14:31,670
+كذلك؟ حسنا، الانتشومسكي لا يحب فكرة الانتصاف، هو
+
+193
+00:14:31,670 --> 00:14:39,950
+يحب الانتصاف بقول إنه لا يحب أن يشاهد هذا الوظيفة
+
+194
+00:14:39,950 --> 00:14:44,930
+المجتمعة، هو يريد أن يشاهد هذا الوظيفة المجتمعة
+
+195
+00:14:44,930 --> 00:14:48,910
+المحفوظة في الحكومة و حتى في الاقتصادليس فقط في
+
+196
+00:14:48,910 --> 00:14:53,310
+الحكومة، بل في الانتصار وفي الاقتصاد. يريد أن يرى
+
+197
+00:14:53,310 --> 00:14:59,110
+هذا القوة .. القوة هنا .. الفاشية .. تتحكم بشكل
+
+198
+00:14:59,110 --> 00:15:02,210
+صغير من الناس اللي كانوا يقتلوها و يحصلوا على ..
+
+199
+00:15:02,210 --> 00:15:07,590
+ماذا يحصلوا على؟ اتحرك مباشر .. اتحرك واحد .. من
+
+200
+00:15:07,590 --> 00:15:11,010
+المشاركين هنا؟ شرهو الله .. لذلك يمكنهم أن يأخذوا
+
+201
+00:15:11,010 --> 00:15:12,930
+القوة، يمكنهم أن يتعاملوا، يمكنهم أن يركضوا.
+
+202
+00:15:15,870 --> 00:15:18,550
+ولكن بالطبع يمكن أن يكون لديه شيء من ميكانيزم
+
+203
+00:15:18,550 --> 00:15:23,370
+لتطبيق هذه القواعد، وفي نفس الوقت يتكلم عن
+
+204
+00:15:23,370 --> 00:15:25,530
+الاختيار القانوني لإنشاء شركة مدينة مدينة مدينة
+
+205
+00:15:25,530 --> 00:15:27,090
+مدينة مدينة مدينة مدينة مدينة مدينة مدينة مدينة
+
+206
+00:15:27,090 --> 00:15:28,070
+مدينة مدينة مدينة مدينة مدينة مدينة مدينة مدينة
+
+207
+00:15:28,070 --> 00:15:29,610
+مدينة مدينة مدينة مدينة مدينة مدينة مدينة مدينة
+
+208
+00:15:29,610 --> 00:15:30,970
+مدينة مدينة مدينة مدينة مدينة مدينة مدينة مدينة
+
+209
+00:15:30,970 --> 00:15:40,570
+مدينة مدينة مدينة مدينة مدينة مدين
+
+210
+00:15:41,440 --> 00:15:48,840
+تخيل شركة تحتوي على آلاف الإنسان كمشاركات و هؤلاء
+
+211
+00:15:48,840 --> 00:15:52,960
+الآلاف .. آلاف آلاف الإنسان يستخدمون المال في شركة
+
+212
+00:15:52,960 --> 00:15:58,520
+واحدة، كم المال سيكون لدى الشركة؟ كم قوة سيكون لدى
+
+213
+00:15:58,520 --> 00:16:02,100
+الشركة؟ شيء لا نستطيع أن نخيله ..
+
+214
+00:16:05,130 --> 00:16:07,750
+in one way or the other if you look at the company
+
+215
+00:16:07,750 --> 00:16:11,910
+as a creature as a fictitious person person or as
+
+216
+00:16:11,910 --> 00:16:15,430
+fictional person the company usually has no power
+
+217
+00:16:15,430 --> 00:16:19,550
+nothing we make it but now after we make the
+
+218
+00:16:19,550 --> 00:16:22,110
+company it becomes immortal what's immortal he
+
+219
+00:16:22,110 --> 00:16:30,690
+said immortal person what's immortal immortal
+
+220
+00:16:30,690 --> 00:16:35,710
+شخص لايموت يعني باقي للأبدالشخص الموتى ويحصل على
+
+221
+00:16:35,710 --> 00:16:42,590
+شيء مذهل ..شيء مذهل ..شيء مذهل ..شيء مذهل ..شيء
+
+222
+00:16:42,590 --> 00:16:43,590
+مذهل ..شيء مذهل ..شيء مذهل ..شيء مذهل ..شيء مذهل
+
+223
+00:16:43,590 --> 00:16:43,650
+..شيء مذهل ..شيء مذهل ..شيء مذهل ..شيء مذهل ..شيء
+
+224
+00:16:43,650 --> 00:16:43,750
+مذهل ..شيء مذهل ..شيء مذهل ..شيء مذهل ..شيء مذهل
+
+225
+00:16:43,750 --> 00:16:43,750
+..شيء مذهل ..شيء مذهل ..شيء مذهل ..شيء مذهل ..شيء
+
+226
+00:16:43,750 --> 00:16:43,750
+مذهل ..شيء مذهل ..شيء مذهل ..شيء مذهل ..شيء مذهل
+
+227
+00:16:43,750 --> 00:16:50,480
+..شيء مذهل ..شيء مذهل ..شيء مذهل ..شيءإذا كان هناك
+
+228
+00:16:50,480 --> 00:16:58,040
+قوة عظيمة وعقل مع شخص غير موتى، فهذه الشركة كشخصة
+
+229
+00:16:58,040 --> 00:17:02,960
+قد تؤثر على الاقتصاد، قد تؤثر على المجتمع، قد
+
+230
+00:17:02,960 --> 00:17:05,580
+تتأثر على الكثير من الناس، الكثير من جزء من
+
+231
+00:17:05,580 --> 00:17:12,860
+حياتنا، لذلك هذا ليس شيءaccepted بينهم in addition
+
+232
+00:17:12,860 --> 00:17:15,900
+to this what he said like even though we create
+
+233
+00:17:15,900 --> 00:17:18,200
+the companies we make them we establish them
+
+234
+00:17:18,200 --> 00:17:24,480
+sometimes those companies who supposed to abide by
+
+235
+00:17:24,480 --> 00:17:28,120
+the law they don't they don't abide by the law
+
+236
+00:17:28,120 --> 00:17:32,140
+what they do they escape the restrictions they
+
+237
+00:17:32,140 --> 00:17:36,820
+have few constraints few constraints what
+
+238
+00:17:36,820 --> 00:17:37,360
+constraints
+
+239
+00:17:40,320 --> 00:17:45,020
+limitations قيول despite this companies escape
+
+240
+00:17:45,020 --> 00:17:50,960
+such constraints and do not abide by the law most
+
+241
+00:17:50,960 --> 00:17:55,060
+of the time or try to escape or avoid legal system
+
+242
+00:17:55,060 --> 00:18:00,780
+this is why some people don't like such idea to
+
+243
+00:18:00,780 --> 00:18:03,100
+have corporations now I guess we have to move to
+
+244
+00:18:03,100 --> 00:18:07,240
+something new a new subject you have any question
+
+245
+00:18:07,240 --> 00:18:08,420
+any question
+
+246
+00:18:11,910 --> 00:18:17,850
+لأ؟ كيف تجدها حتى الآن؟ كيف تجدها بسهولة؟ صعب؟
+
+247
+00:18:17,850 --> 00:18:24,090
+صعب، أليس كذلك؟ هل أحد أخر يجدها صعبة؟ نعم؟ كم صعب
+
+248
+00:18:24,090 --> 00:18:32,630
+هو؟ هل تفهم كل شيء؟ هل تفهم 50% 50%؟ هل أحد يفهم
+
+249
+00:18:32,630 --> 00:18:38,340
+أكتر من 50%؟ فقط ارفع يديك أكتر من 50%raise your
+
+250
+00:18:38,340 --> 00:18:46,080
+hand up only four and the rest of you I
+
+251
+00:18:46,080 --> 00:18:48,580
+just listen I don't want just keep saying things
+
+252
+00:18:48,580 --> 00:18:51,200
+and keep going and if you don't understand it's
+
+253
+00:18:51,200 --> 00:18:54,460
+not good what's the problem is it the language the
+
+254
+00:18:54,460 --> 00:18:55,580
+language subject
+
+255
+00:19:01,610 --> 00:19:03,790
+listen I'm not gonna speak about the exam and how
+
+256
+00:19:03,790 --> 00:19:06,770
+it's not gonna be something you will not expect
+
+257
+00:19:06,770 --> 00:19:09,650
+something will be easy it's not like the midterm
+
+258
+00:19:09,650 --> 00:19:12,890
+exam of course definitely and I will evaluate you
+
+259
+00:19:12,890 --> 00:19:15,810
+in a different way I will evaluate you on your
+
+260
+00:19:15,810 --> 00:19:18,730
+attendance for the class participation listening
+
+261
+00:19:18,730 --> 00:19:22,890
+asking answering I will evaluate you based on your
+
+262
+00:19:22,890 --> 00:19:26,650
+activities in the class not only the exam I will
+
+263
+00:19:26,650 --> 00:19:30,170
+not depend one hundred percent on the exam believe
+
+264
+00:19:30,170 --> 00:19:33,830
+itI will look at you, I know that you small number
+
+265
+00:19:33,830 --> 00:19:36,950
+here and I know you work well and I will look at
+
+266
+00:19:36,950 --> 00:19:39,870
+how much you participate in the class, how much
+
+267
+00:19:39,870 --> 00:19:43,510
+you try to do your best, not just to miss the
+
+268
+00:19:43,510 --> 00:19:51,030
+class or come late, not only the examanyway just
+
+269
+00:19:51,030 --> 00:19:53,990
+if you don't understand one point you can stop me
+
+270
+00:19:53,990 --> 00:19:56,730
+say well this is a little bit difficult I'm
+
+271
+00:19:56,730 --> 00:19:59,270
+talking about simple things I said that three
+
+272
+00:19:59,270 --> 00:20:01,950
+people three main schoolers they did not like the
+
+273
+00:20:01,950 --> 00:20:04,970
+idea of companies or corporations they criticize
+
+274
+00:20:04,970 --> 00:20:09,470
+it because of so and so is it a difficult point
+
+275
+00:20:09,470 --> 00:20:14,530
+it's not just you're not focusing with me because
+
+276
+00:20:14,530 --> 00:20:19,550
+you have exam maybe later isn't it yeahDon't think
+
+277
+00:20:19,550 --> 00:20:21,450
+about the exam, think about what you have in the
+
+278
+00:20:21,450 --> 00:20:23,630
+class here. Now we still have in this chapter
+
+279
+00:20:23,630 --> 00:20:28,770
+about twenty slides, less than twenty slides to go
+
+280
+00:20:28,770 --> 00:20:33,970
+and from now we gonna have some entities, some
+
+281
+00:20:33,970 --> 00:20:38,850
+business entitiesهؤلاء الشركات العملية لديها 10
+
+282
+00:20:38,850 --> 00:20:43,290
+نوع 10 نوع من الشركات العملية يجب أن ننظر إليها
+
+283
+00:20:43,290 --> 00:20:47,830
+واحدة بواسطة واحدة بعضها تجدها صعبة ليس كثير حقا
+
+284
+00:20:47,830 --> 00:20:53,470
+قليل من ذلك لكن بعض هذه الشركات سهل أن تفهمها و
+
+285
+00:20:53,470 --> 00:20:58,270
+سهل أن تتعلمها رقم واحد يجب أن نتحدث عنه اسمه
+
+286
+00:20:58,270 --> 00:21:04,950
+Consumers Cooperative Consumers Cooperative هل
+
+287
+00:21:04,950 --> 00:21:10,110
+سمعت عنه؟stay with me here honey focus on this
+
+288
+00:21:10,110 --> 00:21:14,470
+slide here there's something called consumers
+
+289
+00:21:14,470 --> 00:21:18,530
+cooperative do you have any idea about it not at
+
+290
+00:21:18,530 --> 00:21:26,050
+all ايه بالعربي جمعيات التعاونية simple and easy
+
+291
+00:21:26,050 --> 00:21:29,370
+and people like it so much why because we have
+
+292
+00:21:29,370 --> 00:21:32,110
+many advantages we have many points to look at and
+
+293
+00:21:32,110 --> 00:21:37,660
+understand here for exampleأولاً ننظر إلى ميوتوال
+
+294
+00:21:37,660 --> 00:21:43,880
+بنيفت ميوتوال بنيفت هذا شيء مصنع للفائدة للشركات
+
+295
+00:21:43,880 --> 00:21:49,980
+ليس الشركات نسميها مصنعين نسميها مصنعين نسميها
+
+296
+00:21:49,980 --> 00:21:50,240
+مصنعين نسميها مصنعين نسميها مصنعين نسميها مصنعين
+
+297
+00:21:50,240 --> 00:21:50,240
+نسميها مصنعين نسميها مصنعين نسميها مصنعين نسميها
+
+298
+00:21:50,240 --> 00:21:51,600
+مصنعين نسميها مصنعين نسميها مصنعين نسميها مصنعين
+
+299
+00:21:51,600 --> 00:21:53,980
+نسميها مصنعين نسميها مصنعين نسميها مصنعين نسميها
+
+300
+00:21:53,980 --> 00:22:01,700
+مصنعين نسميها مصنعين نسميها مصنعين نسميها م
+
+301
+00:22:07,710 --> 00:22:11,430
+for about the class? no that was something else I
+
+302
+00:22:11,430 --> 00:22:13,290
+was .. I know you're gonna ask a question like
+
+303
+00:22:13,290 --> 00:22:17,670
+this that was a mutual benefit corporation this
+
+304
+00:22:17,670 --> 00:22:21,230
+one consumer here we have consumers customers we
+
+305
+00:22:21,230 --> 00:22:24,470
+sell we have activities we have transactions but
+
+306
+00:22:24,470 --> 00:22:26,990
+in that one there is or there was no transaction
+
+307
+00:22:26,990 --> 00:22:30,390
+and here you have you can gain money you can gain
+
+308
+00:22:30,390 --> 00:22:33,510
+profit you can gain quality but that one you don't
+
+309
+00:22:33,510 --> 00:22:36,150
+get nothing except of the activities and the
+
+310
+00:22:36,150 --> 00:22:39,790
+service you haveFine؟ Now in consumers cooperative
+
+311
+00:22:39,790 --> 00:22:44,290
+it is a cooperative business it's made by the
+
+312
+00:22:44,290 --> 00:22:47,370
+customers imagine that and I have example I'm
+
+313
+00:22:47,370 --> 00:22:49,430
+gonna speak about the example before we start to
+
+314
+00:22:49,430 --> 00:22:53,790
+make it easier for you imagine that at the Islamic
+
+315
+00:22:53,790 --> 00:22:58,270
+university you have 22000 students isn't it? 22000
+
+316
+00:22:58,270 --> 00:23:03,070
+students and we have two canteens one for male
+
+317
+00:23:03,070 --> 00:23:07,210
+students and one for female studentsthis canteen
+
+318
+00:23:07,210 --> 00:23:12,210
+revenue is lots of money, isn't it؟ you find how
+
+319
+00:23:12,210 --> 00:23:15,190
+much money you spend barely؟ two shekels, five,
+
+320
+00:23:15,330 --> 00:23:17,650
+ten؟ it depends on your budget, sometimes you
+
+321
+00:23:17,650 --> 00:23:20,030
+don't spend nothing, you don't spend nothing
+
+322
+00:23:20,030 --> 00:23:23,830
+sometimes in overall you might have on a daily
+
+323
+00:23:23,830 --> 00:23:26,630
+basis at least twenty five or thirty percent of
+
+324
+00:23:26,630 --> 00:23:31,640
+students buying thingsوالفائعة تذهب إلى مالك
+
+325
+00:23:31,640 --> 00:23:34,580
+المخبز، نحن نستطيع أن نحصل على فكرة جديدة، نستطيع
+
+326
+00:23:34,580 --> 00:23:37,820
+أن نحصل على شركة مجتمع مجتمع مجتمع مجتمع مجتمع
+
+327
+00:23:37,820 --> 00:23:39,920
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+328
+00:23:39,920 --> 00:23:41,000
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+329
+00:23:41,000 --> 00:23:41,260
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+330
+00:23:41,260 --> 00:23:43,560
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+331
+00:23:43,560 --> 00:23:47,260
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+332
+00:23:47,260 --> 00:23:55,900
+مجتمع
+
+333
+00:23:57,480 --> 00:24:01,420
+a million shekel it's a lot of money then you can
+
+334
+00:24:01,420 --> 00:24:05,080
+run two canteens and you can have even more than
+
+335
+00:24:05,080 --> 00:24:08,240
+that you can have the best food with the good
+
+336
+00:24:08,240 --> 00:24:12,500
+quality with hygiene with money coming back to the
+
+337
+00:24:12,500 --> 00:24:15,780
+students themselves so we don't invest in someone
+
+338
+00:24:15,780 --> 00:24:20,780
+else we invest in ourour needs, what we need to
+
+339
+00:24:20,780 --> 00:24:23,560
+do, we have something in common, as students you
+
+340
+00:24:23,560 --> 00:24:26,520
+have something in common, you want to buy good
+
+341
+00:24:26,520 --> 00:24:30,560
+food, hygiene, I mean clean, you want to have high
+
+342
+00:24:30,560 --> 00:24:33,300
+quality, you want to have it cheap, cheaper than
+
+343
+00:24:33,300 --> 00:24:36,820
+outside, then you can invest, everyone can pay 10,
+
+344
+00:24:36,880 --> 00:24:40,340
+20 shekels, that's for once, only once, and that's
+
+345
+00:24:40,340 --> 00:24:44,620
+your money, that's your shareسهم أو أسهم that's
+
+346
+00:24:44,620 --> 00:24:47,480
+your share you pay that for once and you keep it
+
+347
+00:24:47,480 --> 00:24:50,280
+and you .. you become a member you are a member in
+
+348
+00:24:50,280 --> 00:24:54,060
+the consumer cooperative then you can .. like you
+
+349
+00:24:54,060 --> 00:24:58,820
+can be the customers, you can be the ownersand you
+
+350
+00:24:58,820 --> 00:25:02,160
+can be the employees we're not gonna bring someone
+
+351
+00:25:02,160 --> 00:25:04,720
+from outside you can work as well you can get the
+
+352
+00:25:04,720 --> 00:25:07,700
+money you can get the food you can get the benefit
+
+353
+00:25:07,700 --> 00:25:10,340
+if you have extra money at the end of the year the
+
+354
+00:25:10,340 --> 00:25:14,460
+extra money we can invest it again in the consumer
+
+355
+00:25:14,460 --> 00:25:18,080
+cooperative or we can divide it between members
+
+356
+00:25:18,080 --> 00:25:21,660
+easy imagine that would be a good idea not even
+
+357
+00:25:21,660 --> 00:25:24,060
+the canteen you can invest in the bookshop في
+
+358
+00:25:24,060 --> 00:25:27,250
+المكتبةماذا يجب أن يأخذ أحدكم المال؟ يمكنك أن
+
+359
+00:25:27,250 --> 00:25:32,930
+تستخدم مالك و تحصل على شيء أفضل، بقوة أفضل، و يمكن
+
+360
+00:25:32,930 --> 00:25:39,210
+أن يكون أفضل من السوقهذا ما يسمى ميوتوال بنيفت،
+
+361
+00:25:39,210 --> 00:25:43,030
+فالهدف ليه ليس أن نحصل على المال، لكن أن نحصل على
+
+362
+00:25:43,030 --> 00:25:45,870
+ميوتوال بنيفت، نستطيع أن نفعل شيء، نستطيع أن
+
+363
+00:25:45,870 --> 00:25:49,250
+نستخدم ذلك الشيء، لماذا يجب أن نعتمد على السوق؟
+
+364
+00:25:49,250 --> 00:25:52,610
+لماذا يجب أن نعتمد على بعض الشركات والشركات العامة
+
+365
+00:25:52,610 --> 00:25:56,650
+والشركات العامة؟ نستطيع أن نحصل على شركة حرة بين
+
+366
+00:25:56,650 --> 00:26:00,840
+بعضنا البعض، في هذه الدراسةin the faculty of
+
+367
+00:26:00,840 --> 00:26:03,780
+commerce you can have your own club I mean you
+
+368
+00:26:03,780 --> 00:26:07,280
+have consumer cooperative for students who can ..
+
+369
+00:26:07,280 --> 00:26:10,380
+can sell books and stationaries .. stationaries هي
+
+370
+00:26:10,380 --> 00:26:16,260
+نوع stationary؟ أدوات المكتبة stationary أدوات
+
+371
+00:26:16,260 --> 00:26:18,960
+المكتبة you can sell stationaries other books and
+
+372
+00:26:18,960 --> 00:26:20,120
+articles and whatever things
+
+373
+00:26:23,140 --> 00:26:26,620
+الشركات العامة هي الشركات العامة التي تدفع المال
+
+374
+00:26:26,620 --> 00:26:30,440
+للشركات العامة كشركات عامة تقدر تدفع المال للشركات
+
+375
+00:26:30,440 --> 00:26:33,680
+العامة كشركات عامة تقدر تدفع المال للشركات العامة
+
+376
+00:26:33,680 --> 00:26:34,940
+كشركات عامة تقدر تدفع المال للشركات العامة كشركات
+
+377
+00:26:34,940 --> 00:26:37,780
+عامة تقدر تدفع المال للشركات العامة كشركات عامة
+
+378
+00:26:37,780 --> 00:26:39,700
+تقدر تدفع المال للشركات العامة كشركات عامة تقدر
+
+379
+00:26:39,700 --> 00:26:39,740
+تدفع المال للشركات العامة كشركات عامة تقدر تدفع
+
+380
+00:26:39,740 --> 00:26:42,440
+المال للشركات العامة كشركات عامة تقدر تدفع المال
+
+381
+00:26:42,440 --> 00:26:48,480
+للشركات العامة كشركات عامة تقدر تد
+
+382
+00:26:51,140 --> 00:26:54,340
+insurance، housing، agriculture، most of them we
+
+383
+00:26:54,340 --> 00:26:56,960
+have in .. in .. in many countries especially
+
+384
+00:26:56,960 --> 00:26:59,520
+third world countries، agriculture، جامعات زراعية
+
+385
+00:26:59,520 --> 00:27:04,500
+تعاونية، agriculture and utility، cooperative،
+
+386
+00:27:04,500 --> 00:27:09,030
+المنفعة أو الخدمات .. الخدمات العامةهذا يعتمد على
+
+387
+00:27:09,030 --> 00:27:13,230
+اهتمام بعض الناس وماذا يريدون أن يفعلوه و كم مال
+
+388
+00:27:13,230 --> 00:27:16,250
+يريدون أن تستخدموه و كم ناس يريدون أن يتعاملوا معه
+
+389
+00:27:16,250 --> 00:27:20,590
+انا اتذكر قبل عدة سنة ان الشركة الفلسطينية لديها
+
+390
+00:27:20,590 --> 00:27:26,910
+شيء مثل هذا عادة هذا مفتوح فقط لجمهور الذين
+
+391
+00:27:26,910 --> 00:27:32,770
+يتعاملون في شركة شركة شركة شركة شركة شركة شركة
+
+392
+00:27:32,770 --> 00:27:34,390
+شركة شركة
+
+393
+00:27:37,280 --> 00:27:40,740
+to the public so the public can come and buy from
+
+394
+00:27:40,740 --> 00:27:44,520
+there and the benefit can go for the members but
+
+395
+00:27:44,520 --> 00:27:48,100
+in general general this is a limited type limited
+
+396
+00:27:48,100 --> 00:27:52,180
+to the members we can be fifty fifty thousand can
+
+397
+00:27:52,180 --> 00:27:55,440
+be half a million people we are society one
+
+398
+00:27:55,440 --> 00:27:58,380
+society مجتمع واحد one society we can have our own
+
+399
+00:27:58,380 --> 00:27:58,720
+business
+
+400
+00:28:02,840 --> 00:28:05,840
+Why should we have something like this؟ Why can't
+
+401
+00:28:05,840 --> 00:28:10,580
+we go for a company like limited liability company
+
+402
+00:28:10,580 --> 00:28:15,400
+or partnership؟ Why can't we choose this type؟
+
+403
+00:28:15,400 --> 00:28:18,240
+What's the benefit؟ What's the advantage in this
+
+404
+00:28:18,240 --> 00:28:22,240
+type consumer cooperative؟ By the way, many people
+
+405
+00:28:22,240 --> 00:28:25,630
+would like to go for this typemany people like it
+
+406
+00:28:25,630 --> 00:28:27,870
+because we have many advantages as we will see in
+
+407
+00:28:27,870 --> 00:28:31,350
+the last slide in this many schoolers like the
+
+408
+00:28:31,350 --> 00:28:34,250
+idea of having consumer cooperated and once we
+
+409
+00:28:34,250 --> 00:28:37,630
+finish it we look how many advantages we have what
+
+410
+00:28:37,630 --> 00:28:41,910
+the benefit what do you think yes
+
+411
+00:28:45,910 --> 00:28:51,590
+لو كوست، ويكون أقل من مجتمع وقيمة عالية، مثلا إذا
+
+412
+00:28:51,590 --> 00:28:54,050
+كنت تريد أن تشتري كمبيوتر مثل هذا، هذا الكمبيوتر
+
+413
+00:28:54,050 --> 00:28:58,890
+الذي يمكن أن يكلفك في المجتمع 500 ريال، فربما تدفع
+
+414
+00:28:58,890 --> 00:29:05,030
+فقط 420 ريال في شركة Consumer Corporateبسبب الفرق
+
+415
+00:29:05,030 --> 00:29:10,030
+اللي ستكونه في الشركة كمفروض انها منك، ستأخذها
+
+416
+00:29:10,030 --> 00:29:14,810
+مجددا، هنا الهدف هو consumer corporate ان يقدموا
+
+417
+00:29:14,810 --> 00:29:21,730
+أسعار جيدة و أقل سعر، أقل
+
+418
+00:29:21,730 --> 00:29:27,590
+سعر أو أقل سعر في عملية، في عملية، ستشتري نفس
+
+419
+00:29:27,590 --> 00:29:31,800
+الشيء اللي في السوق، كم سعر في السوق ستشتريدعونا
+
+420
+00:29:31,800 --> 00:29:36,680
+نقول أن هذا الجاكت يكلف في المarket 150 شيكل في
+
+421
+00:29:36,680 --> 00:29:40,400
+الماركت نحن يجب أن نشتريه في شركة المستخدم مع نفس
+
+422
+00:29:40,400 --> 00:29:45,640
+المال 150 شيكل فما هو الفائعة؟ إذا كنا نستطيع أن
+
+423
+00:29:45,640 --> 00:29:48,740
+نشتريه في الماركت في نفس الوقت فما هو الفائعة اللي
+
+424
+00:29:48,740 --> 00:29:54,620
+نستطيع أن نحصل عليها؟ فما هو الموضوع؟ أنت لم
+
+425
+00:29:54,620 --> 00:30:00,370
+تتبعني جيدا في العمليجب أن نقل السعر إلى قيمة
+
+426
+00:30:00,370 --> 00:30:01,830
+مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية
+
+427
+00:30:01,830 --> 00:30:02,330
+مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية
+
+428
+00:30:02,330 --> 00:30:04,330
+مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية
+
+429
+00:30:04,330 --> 00:30:05,510
+مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية
+
+430
+00:30:05,510 --> 00:30:08,550
+مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية
+
+431
+00:30:08,550 --> 00:30:09,990
+مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية
+
+432
+00:30:09,990 --> 00:30:12,350
+مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية
+
+433
+00:30:31,910 --> 00:30:40,070
+و مرة أخرى نحن لدينا كم هو قيمته؟ قيمته 420 دولار
+
+434
+00:30:40,070 --> 00:30:46,470
+و نستطيع أن نشتري 500 دولار نحن
+
+435
+00:30:46,470 --> 00:30:50,610
+لدينا فرق بين كم هو قيمته هنا نحن لدينا اثنين نوع
+
+436
+00:30:50,610 --> 00:30:55,250
+من الشركات، نحن نحن نحن نحن نحن نحن نحن نحن نحن
+
+437
+00:30:55,250 --> 00:30:55,250
+نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن
+
+438
+00:30:55,250 --> 00:30:55,870
+نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن
+
+439
+00:30:55,870 --> 00:30:56,610
+نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن
+
+440
+00:30:56,610 --> 00:31:02,760
+نحن نحن نحن نحن نحمنفع متبادل بيننا mutual benefit
+
+441
+00:31:02,760 --> 00:31:05,840
+now in the first time I need somebody to read it
+
+442
+00:31:05,840 --> 00:31:11,300
+here for me can you? for a profit enterprise will
+
+443
+00:31:11,300 --> 00:31:13,860
+it create the difference between costs including
+
+444
+00:31:13,860 --> 00:31:18,700
+labor and civil rights as financial gain? the
+
+445
+00:31:18,700 --> 00:31:21,880
+eight dollars that's the difference this if it's a
+
+446
+00:31:21,880 --> 00:31:27,680
+profit company then we call it what we call it we
+
+447
+00:31:27,680 --> 00:31:34,940
+call itفنانشال جين فنانشال جين فأنا
+
+448
+00:31:34,940 --> 00:31:48,860
+قمت بالخطأ هنا كم
+
+449
+00:31:48,860 --> 00:31:53,820
+يستغرق وكم نبيع الفعالية الفرق بينهم هذا هو
+
+450
+00:31:53,820 --> 00:31:58,790
+الفعالية اذا كانت شركة مالية هذا الفعاليةهو اكتشاف
+
+451
+00:31:58,790 --> 00:32:02,650
+عندما يجب علينا أن ندفع دولة لذلك و يمكن أن يكون
+
+452
+00:32:02,650 --> 00:32:07,430
+هذا مقاطع بين الشركات في نهاية العام ولكن في شركة
+
+453
+00:32:07,430 --> 00:32:11,670
+غير اكتشاف و في شركة شركة مستخدمة مستخدمة مستخدمة
+
+454
+00:32:11,670 --> 00:32:12,550
+مستخدمة مستخدمة مستخدمة مستخدمة مستخدمة مستخدمة
+
+455
+00:32:12,550 --> 00:32:14,310
+مستخدمة مستخدمة مستخدمة مستخدمة مستخدمة مستخدمة
+
+456
+00:32:14,310 --> 00:32:15,270
+مستخدمة مستخدمة مستخدمة مستخدمة مستخدمة مستخدمة
+
+457
+00:32:15,270 --> 00:32:17,770
+مستخدمة مستخدمة مستخدمة مستخدمة مستخدمة مستخدمة
+
+458
+00:32:17,770 --> 00:32:26,110
+مستخدمة مستخدمة مستخدمة
+
+459
+00:32:26,110 --> 00:32:33,520
+مستخدمة مإذا كانت دفعة زائدة دفعة زائدة اكتر دفعة
+
+460
+00:32:33,520 --> 00:32:40,880
+زائدة اكتر
+
+461
+00:32:40,880 --> 00:32:45,640
+دفعة زائدة اكتر دفعة زائدة اكترأقل من ما لدينا في
+
+462
+00:32:45,640 --> 00:32:48,540
+السوق ولكن في نهاية العام لدينا أكثر أمان لدينا
+
+463
+00:32:48,540 --> 00:32:50,020
+أكثر أمان لدينا أكثر أمان لدينا هذه الأمان الأكثر
+
+464
+00:32:50,020 --> 00:32:51,800
+أمان لدينا لدينا أكثر أمان لدينا أكثر أمان لدينا
+
+465
+00:32:51,800 --> 00:32:54,280
+أكثر أمان لدينا أكثر أمان لدينا أكثر أمان لدينا
+
+466
+00:32:54,280 --> 00:32:54,940
+أكثر أمان لدينا أكثر أمان لدينا أكثر أمان لدينا
+
+467
+00:32:54,940 --> 00:32:57,120
+أكثر أمان لدينا أكثر أمان لدينا أكثر أمان لدينا
+
+468
+00:32:57,120 --> 00:32:58,660
+أكثر أمان لدينا أكثر أمان لدينا أكثر أمان لدينا
+
+469
+00:32:58,660 --> 00:33:03,120
+أكثر أمان لدينا أكثر أمان لدينا أكثر أمان لدينا
+
+470
+00:33:03,120 --> 00:33:07,540
+أكثر
+
+471
+00:33:07,540 --> 00:33:10,260
+أمان
+
+472
+00:33:13,100 --> 00:33:16,800
+هذا المال الاضافى يمكننا أن نستخدمه مرة أخرى في
+
+473
+00:33:16,800 --> 00:33:19,580
+نفس الشركة المشتركة أو يمكننا أن نقوم بتقرير بين
+
+474
+00:33:19,580 --> 00:33:24,200
+مثلًا دعنا نقول أننا قمنا بإستخدام واحد مليون واحد
+
+475
+00:33:24,200 --> 00:33:28,840
+مليون دولار واحد مليون دولار بين 20000 أشخاص واحد
+
+476
+00:33:28,840 --> 00:33:32,100
+مليون دولار لكن في نهاية العام جعلنا واحد مليون
+
+477
+00:33:32,100 --> 00:33:38,820
+نحصل على المال وجعلنا 200 ألف دولار اضافى هذا ليس
+
+478
+00:33:38,820 --> 00:33:45,370
+نسبةالتعامل التعامل التعامل التعامل التعامل
+
+479
+00:33:45,370 --> 00:33:47,850
+التعامل التعامل التعامل التعامل التعامل التعامل
+
+480
+00:33:47,850 --> 00:33:50,370
+التعامل التعامل التعامل التعامل التعامل التعامل
+
+481
+00:33:50,370 --> 00:33:56,370
+التعامل التعامل التعامل التعامل التعامل التعامل
+
+482
+00:33:56,370 --> 00:33:57,770
+التعامل التعامل التعامل التعامل التعامل التعامل
+
+483
+00:33:57,770 --> 00:33:59,450
+التعامل التعامل التعامل التعامل التعامل التعامل
+
+484
+00:33:59,450 --> 00:33:59,450
+التعامل التعامل التعامل التعامل التعامل التعامل
+
+485
+00:33:59,450 --> 00:33:59,470
+التعامل التعامل التعامل التعامل التعامل التعامل
+
+486
+00:33:59,470 --> 00:34:01,050
+التعامل التعامل التعامل التعامل التعامل التعامل
+
+487
+00:34:01,050 --> 00:34:07,270
+التعامل التعامل التعام
+
+488
+00:34:08,270 --> 00:34:13,310
+لدينا صفر صغير و لدينا صفر كبير، يتعامل على عدد
+
+489
+00:34:13,310 --> 00:34:16,410
+الناس اللي يريد ان يتعامل معها و يتعامل على عدد
+
+490
+00:34:16,410 --> 00:34:20,250
+المال اللي اهتم بهذا، يتعامل على اتنين حالات،
+
+491
+00:34:20,250 --> 00:34:25,710
+يتعامل على عدد الناس
+
+492
+00:34:25,710 --> 00:34:26,950
+اللي يريد ان يتعامل معها، يتعامل على عدد الناس
+
+493
+00:34:26,950 --> 00:34:28,650
+اللي يريد ان يتعامل معها، يتعامل على عدد الناس
+
+494
+00:34:28,650 --> 00:34:28,950
+اللي يريد ان يتعامل معها، يتعامل على عدد الناس
+
+495
+00:34:28,950 --> 00:34:30,510
+اللي يريد ان يتعامل معها، يتعامل على عدد الناس
+
+496
+00:34:30,510 --> 00:34:36,390
+اللي يريد ان يتعامل معها، يتعامل على عدد الناس
+
+497
+00:34:36,390 --> 00:34:38,940
+اللي يThen this would need .. this would require
+
+498
+00:34:38,940 --> 00:34:43,360
+some people to work You might need chef, you might
+
+499
+00:34:43,360 --> 00:34:47,300
+need a waiter, you might need a cleaner, isn't it؟
+
+500
+00:34:47,300 --> 00:34:51,640
+You might need managers, you might need a medical
+
+501
+00:34:51,640 --> 00:34:55,260
+doctor, you might need a nurse You might need many
+
+502
+00:34:55,260 --> 00:34:57,800
+people and staff to work for you, what can you do؟
+
+503
+00:34:57,800 --> 00:35:00,860
+We have to employ people from where؟ Well look at
+
+504
+00:35:00,860 --> 00:35:03,780
+the memberswe can take it from the same society
+
+505
+00:35:03,780 --> 00:35:06,740
+like we needed a medical doctor but we could not
+
+506
+00:35:06,740 --> 00:35:09,820
+find any one of you medical doctor what can we do؟
+
+507
+00:35:09,820 --> 00:35:12,160
+we need someone to look at the hygiene someone
+
+508
+00:35:12,160 --> 00:35:18,290
+specialist in dietary اللي تعرف الدياترو لا نستطيع
+
+509
+00:35:18,290 --> 00:35:20,990
+أن نجد أحد ثم نستطيع أن نجد أحد من خارج المجتمع
+
+510
+00:35:20,990 --> 00:35:25,290
+أنه أو أنها ستعمل لنا و يجب أن ندفعهم لهم لدينا
+
+511
+00:35:25,290 --> 00:35:28,530
+أشياء لدينا رئيسين و مصادر و مصادر و مصادر و مصادر
+
+512
+00:35:28,530 --> 00:35:29,270
+و مصادر و مصادر و مصادر و مصادر و مصادر و مصادر و
+
+513
+00:35:29,270 --> 00:35:30,010
+مصادر و مصادر و مصادر و مصادر و مصادر و مصادر و
+
+514
+00:35:30,010 --> 00:35:31,970
+مصادر و مصادر و مصادر و مصادر و مصادر و مصادر و
+
+515
+00:35:31,970 --> 00:35:35,810
+مصادر و مصادر و مصادر و مصادر و مصادر و مصادر و
+
+516
+00:35:35,810 --> 00:35:40,770
+مصادر و
+
+517
+00:35:40,770 --> 00:35:45,170
+مصادر و
+
+518
+00:35:45,170 --> 00:35:51,380
+مصادor not؟ we have some people saying yes other
+
+519
+00:35:51,380 --> 00:35:57,520
+scholars said no if it's a small business small
+
+520
+00:35:57,520 --> 00:36:00,360
+consumer cooperative most likely we don't need
+
+521
+00:36:00,360 --> 00:36:03,580
+anyone from outside we can take some members
+
+522
+00:36:03,580 --> 00:36:07,980
+workers we can work from those members it means
+
+523
+00:36:07,980 --> 00:36:12,260
+that you can be consumer member invest your money
+
+524
+00:36:12,260 --> 00:36:16,730
+and you can be an employeeWe get to the point
+
+525
+00:36:16,730 --> 00:36:18,950
+sometimes in which we have some consumer
+
+526
+00:36:18,950 --> 00:36:23,370
+cooperative having here wholesale cooperative
+
+527
+00:36:23,370 --> 00:36:26,490
+wholesale societies having their own factories
+
+528
+00:36:26,490 --> 00:36:30,030
+like again coming back to the same example looking
+
+529
+00:36:30,030 --> 00:36:34,490
+at the canteens having 22000 students how many
+
+530
+00:36:34,490 --> 00:36:41,820
+sandwich you sell per day 10 thousand sandwichأو
+
+531
+00:36:41,820 --> 00:36:44,880
+ربما أكتر، لأنك لا تأكل مرة واحدة، ربما تأكل ثلاثة
+
+532
+00:36:44,880 --> 00:36:50,980
+أو أربعة أحيانا، ثم يجب أن تشتري بريد، يجب أن
+
+533
+00:36:50,980 --> 00:36:53,820
+تشتريه من الخارج، يجب أن تكون لديك بكري
+
+534
+00:36:57,020 --> 00:37:00,380
+إذا كان هذا المجموعة من الناس اللي لدينا، هذا
+
+535
+00:37:00,380 --> 00:37:03,100
+المجموعة من الناس اللي لدينا، ملايين من الناس،
+
+536
+00:37:03,100 --> 00:37:06,500
+فنحن يجب أن نحصل على شيء جاهز لهم، نحن يجب أن نحصل
+
+537
+00:37:06,500 --> 00:37:10,420
+على شيء جاهز لهم، نستطيع أن نشتريه من الخارج،
+
+538
+00:37:10,420 --> 00:37:13,560
+نستطيع أن نحصل على مصنع نفسنا، نستطيع أن نحصل على
+
+539
+00:37:13,560 --> 00:37:19,360
+مطبخ نفسنا، مطبخ، ونستطيع أن نحصل على كل شيء جاهز
+
+540
+00:37:19,360 --> 00:37:24,550
+للمستخدمينSo this would lead to have here to sell
+
+541
+00:37:24,550 --> 00:37:27,430
+even having sometimes can have wholesale price
+
+542
+00:37:27,430 --> 00:37:30,030
+بالجملة ببيبقى بالجملة بشفرة بالجملة you can buy
+
+543
+00:37:30,030 --> 00:37:34,710
+you can sell by wholesale price I mean consumer
+
+544
+00:37:34,710 --> 00:37:37,010
+cooperative is not limited to a small number of
+
+545
+00:37:37,010 --> 00:37:39,670
+people and I know that some consumer cooperative
+
+546
+00:37:39,670 --> 00:37:41,830
+having thousands and tens of thousands of
+
+547
+00:37:41,830 --> 00:37:46,250
+customers and some of them even can open the doors
+
+548
+00:37:46,250 --> 00:37:50,960
+to the public you can sell to themلا يجب عليك أن
+
+549
+00:37:50,960 --> 00:37:56,420
+تحرر نفسك لجمهورك نفسك بعضهم يفتح الباب للشركات من
+
+550
+00:37:56,420 --> 00:37:57,060
+الشباب من الشباب من الشباب من الشباب من الشباب من
+
+551
+00:37:57,060 --> 00:37:57,920
+الشباب من الشباب من الشباب من الشباب من الشباب من
+
+552
+00:37:57,920 --> 00:37:58,940
+الشباب من الشباب من الشباب من الشباب من الشباب من
+
+553
+00:37:58,940 --> 00:38:00,380
+الشباب من الشباب من الشباب من الشباب من الشباب من
+
+554
+00:38:00,380 --> 00:38:02,400
+الشباب من الشباب من الشباب من الشباب من الشباب من
+
+555
+00:38:02,400 --> 00:38:03,580
+الشباب من الشباب من الشباب من الشباب من الشباب من
+
+556
+00:38:03,580 --> 00:38:03,640
+الشباب من الشباب من الشباب من الشباب من الشباب من
+
+557
+00:38:03,640 --> 00:38:03,640
+الشباب من الشباب من الشباب من الشباب من الشباب من
+
+558
+00:38:03,640 --> 00:38:07,560
+الشباب من الشباب من الشباب من الشباب من الشباب من
+
+559
+00:38:07,560 --> 00:38:15,880
+الشباب من
+
+560
+00:38:15,880 --> 00:38:22,860
+الشبابولكن هذا مستحيل، لماذا يجب أن تدفع أقل من
+
+561
+00:38:22,860 --> 00:38:27,200
+أشخاص أخرين في السوق؟ تحصل على المال، تحصل على
+
+562
+00:38:27,200 --> 00:38:31,000
+قيمة أقل من ما يجب أن نحصل على في السوق؟ الشرطة
+
+563
+00:38:31,000 --> 00:38:34,240
+تساعد، الشرطة تساعد في كل شيء، الشرطة تصنع
+
+564
+00:38:34,240 --> 00:38:38,960
+القواعد، الشرطة تصنع الأشياء بسهولة لكل شخص، فعليك
+
+565
+00:38:38,960 --> 00:38:44,200
+أن تدفع المال، إنها فكرة على أي حال،
+
+566
+00:38:44,200 --> 00:38:48,820
+علينا أن ننظر إلى الحكومةgovernance إدارة الشركة
+
+567
+00:38:48,820 --> 00:38:52,900
+management the management of such consumer
+
+568
+00:38:52,900 --> 00:38:57,620
+cooperative how can we manage it how can we manage
+
+569
+00:38:57,620 --> 00:39:01,500
+do
+
+570
+00:39:01,500 --> 00:39:06,000
+we have election yes imagine that we have twenty
+
+571
+00:39:06,000 --> 00:39:10,400
+thousand members who can manage who can run anyone
+
+572
+00:39:10,400 --> 00:39:15,980
+isn't itلدينا نظام الانتجار، في الشركات اللي قلنا
+
+573
+00:39:15,980 --> 00:39:18,460
+عنها، في الشركات اللي قلنا عنها، إذا كانت شركات
+
+574
+00:39:18,460 --> 00:39:22,480
+مالية، لدينا نظام الانتجار، وكم عدد الانتجار اللي
+
+575
+00:39:22,480 --> 00:39:25,080
+يمكنك أن تكون، يعتمد على كم المال اللي تستخدمه،
+
+576
+00:39:25,080 --> 00:39:28,820
+لسنا لدينا ايقال، لسنا لدينا ايقال شيرز، لسنا
+
+577
+00:39:28,820 --> 00:39:31,760
+لدينا ايقال انتجارات ايقال، لا، لربما لدي 5
+
+578
+00:39:31,760 --> 00:39:33,900
+انتجارات، لربما لديك 1 انتجار، يعتمد على كم المال
+
+579
+00:39:33,900 --> 00:39:39,300
+اللي نستخدمه، لكن في هذا الوقت، ليس كذلكواحد شخص
+
+580
+00:39:39,300 --> 00:39:46,500
+واحد مجلس واحد مجلس واحد
+
+581
+00:39:46,500 --> 00:39:55,130
+مجلس واحد مجلس واحد مجلس واحد مجلس واحد مجلسفي
+
+582
+00:39:55,130 --> 00:39:57,210
+شركة شركة Consumers Cooperative و أريد أن أدفع
+
+583
+00:39:57,210 --> 00:40:02,390
+2000 ريال و أحد منكم يمكن أن يدفع 200 ريال فقط
+
+584
+00:40:02,390 --> 00:40:08,470
+ولكن كل واحد مننا سيحصل على واحد فتح واحد فتح واحد
+
+585
+00:40:08,470 --> 00:40:10,050
+واحد واحد واحد واحد واحد واحد واحد واحد واحد واحد
+
+586
+00:40:10,050 --> 00:40:10,050
+واحد واحد واحد واحد واحد واحد واحد واحد واحد واحد
+
+587
+00:40:10,050 --> 00:40:10,050
+واحد واحد واحد واحد واحد واحد واحد واحد واحد واحد
+
+588
+00:40:10,050 --> 00:40:10,730
+واحد واحد واحد واحد واحد واحد واحد واحد واحد واحد
+
+589
+00:40:10,730 --> 00:40:11,010
+واحد واحد واحد واحد واحد واحد واحد واحد واحد واحد
+
+590
+00:40:11,010 --> 00:40:11,670
+واحد واحد واحد واحد واحد واحد واحد واحد واحد واحد
+
+591
+00:40:11,670 --> 00:40:11,990
+واحد واحد واحد واحد واحد واحد واحد واحد واحد واحد
+
+592
+00:40:11,990 --> 00:40:17,750
+واحد واحد واحد واحد واحد واحد واحد
+
+593
+00:40:17,750 --> 00:40:22,290
+واحد
+
+594
+00:40:22,290 --> 00:40:23,450
+وا
+
+595
+00:40:27,630 --> 00:40:32,430
+وهو مجرد مؤسسة ومؤسسات
+
+596
+00:40:32,430 --> 00:40:34,970
+ومؤسسات ومؤسسات ومؤسسات ومؤسسات ومؤسسات ومؤسسات
+
+597
+00:40:34,970 --> 00:40:35,070
+ومؤسسات ومؤسسات ومؤسسات ومؤسسات ومؤسسات ومؤسسات
+
+598
+00:40:35,070 --> 00:40:35,650
+ومؤسسات ومؤسسات ومؤسسات ومؤسسات ومؤسسات ومؤسسات
+
+599
+00:40:35,650 --> 00:40:36,710
+ومؤسسات ومؤسسات ومؤسسات ومؤسسات ومؤسسات ومؤسسات
+
+600
+00:40:36,710 --> 00:40:37,630
+ومؤسسات ومؤسسات ومؤسسات ومؤسسات ومؤسسات ومؤسسات
+
+601
+00:40:37,630 --> 00:40:46,590
+ومؤسسات ومؤسسات ومؤسسات ومؤسسات
+
+602
+00:40:46,590 --> 00:40:47,270
+وم
+
+603
+00:40:56,390 --> 00:41:00,830
+هم يستطيعون ان يصنعوا مقاومة يستطيعون ان يقوموا
+
+604
+00:41:00,830 --> 00:41:04,310
+بكل نوع من التعاملات و يستطيعوا ان يصنعوا عامة
+
+605
+00:41:04,310 --> 00:41:07,890
+التعاملات اعني عامة التعاملات يستطيعوا ان يصنعوا
+
+606
+00:41:07,890 --> 00:41:09,970
+عامة التعاملات كم يجب علينا أن نستخدمه كم يجب
+
+607
+00:41:09,970 --> 00:41:13,470
+علينا أن نقوم بإنقاذه كل عام و يكون لديهم مجتمع
+
+608
+00:41:13,470 --> 00:41:16,770
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+609
+00:41:16,770 --> 00:41:16,810
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+610
+00:41:16,810 --> 00:41:22,920
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجهذه
+
+611
+00:41:22,920 --> 00:41:26,920
+المجتمعات مصممة مصممة مصممة مصممة مصممة مصممة
+
+612
+00:41:26,920 --> 00:41:27,760
+مصممة مصممة مصممة مصممة مصممة مصممة مصممة مصممة
+
+613
+00:41:27,760 --> 00:41:28,400
+مصممة مصممة مصممة مصممة مصممة مصممة مصممة مصممة
+
+614
+00:41:28,400 --> 00:41:29,480
+مصممة مصممة مصممة مصممة مصممة مصممة مصممة مصممة
+
+615
+00:41:29,480 --> 00:41:31,800
+مصممة مصممة مصممة مصممة مصممة مصممة مصممة مصممة
+
+616
+00:41:31,800 --> 00:41:31,800
+مصممة مصممة مصممة مصممة مصممة مصممة مصممة مصممة
+
+617
+00:41:31,800 --> 00:41:37,860
+مصممة مصممة مصممة مصممة مصممة مصممة مصممة مصممة
+
+618
+00:41:49,910 --> 00:41:54,490
+200000 pound this was over payment how can we
+
+619
+00:41:54,490 --> 00:42:01,990
+divide it listen
+
+620
+00:42:01,990 --> 00:42:06,010
+look at this again stay with me hereالآن لدينا
+
+621
+00:42:06,010 --> 00:42:10,470
+واحد مجلد لكل مجلد هذا المال اللي نجعله 200 ألف
+
+622
+00:42:10,470 --> 00:42:14,430
+باونز ومقابلات عامة هذا لا يجب أن يكون يجب أن لا
+
+623
+00:42:14,430 --> 00:42:19,150
+يكون مقاطعاً بمجلد كل مجلد بمجلد نفس الشراء بمجلد
+
+624
+00:42:19,150 --> 00:42:26,330
+نفس المال يجب أن يكون مقاطعاً بمجلد شراء بمجلد
+
+625
+00:42:26,330 --> 00:42:30,690
+الشراء بمجلد المال اللي نستخدمه بسبب كم نستخدمه
+
+626
+00:42:30,690 --> 00:42:35,660
+انا استخدم 10 ألف باونز وانت استخدمه فقط200 باونز
+
+627
+00:42:35,660 --> 00:42:40,200
+يجب أن نحصل على هذا المال مقيم بين شرفه و الله
+
+628
+00:42:40,200 --> 00:42:48,060
+باسم المال اللي قاموا باستخدامه مقيم مجموع المال
+
+629
+00:42:48,060 --> 00:42:49,260
+اللي قاموا باستخدامه مقيم مجموع المال اللي قاموا
+
+630
+00:42:49,260 --> 00:42:54,260
+باستخدامه مقيم مقيم مقيم مقيم مقيم مقيم مقيم مقيم
+
+631
+00:42:54,260 --> 00:42:54,500
+مقيم مقيم مقيم مقيم مقيم مقيم مقيم مقيم مقيم مقيم
+
+632
+00:42:54,500 --> 00:42:54,780
+مقيم مقيم مقيم مقيم مقيم مقيم مقيم مقيم مقيم مقيم
+
+633
+00:42:54,780 --> 00:42:55,280
+مقيم مقيم مقيم مقيم مقيم مقيم مقيم مقيم مقيم مقيم
+
+634
+00:42:55,280 --> 00:43:00,520
+مقيم مقيم مقيم مقيم مقيم مقيم مقيم مقيم مق
+
+635
+00:43:03,990 --> 00:43:09,670
+نحن لدينا 20 ألف طلاب جميعهم
+
+636
+00:43:09,670 --> 00:43:13,950
+طلاب في المدرسة الإسلامية ونحن في شركة شركة
+
+637
+00:43:13,950 --> 00:43:16,370
+Consumers Cooperative كيف يمكننا أن نتعامل معها؟
+
+638
+00:43:16,370 --> 00:43:18,990
+نحن لدينا الاختيار، نحن قمنا بالتعامل معها ولدينا
+
+639
+00:43:18,990 --> 00:43:25,090
+9 شخص، 1,2,3,4,5,6,7,8,9 شخصين، هم مديرين، كيف
+
+640
+00:43:25,090 --> 00:43:28,670
+يمكنهم أن يتعامل معها؟ لديهم لا تجربة، هذا مشكلة،
+
+641
+00:43:28,670 --> 00:43:33,710
+أكتر من الناس في شركة Consumers Cooperativeهذا
+
+642
+00:43:33,710 --> 00:43:34,950
+يعني إذا كنا لسنا لدينا مجتمع ديمقراطي، فإذا كنا
+
+643
+00:43:34,950 --> 00:43:37,230
+لسنا لدينا مجتمع ديمقراطي، فإذا كنا لسنا لدينا
+
+644
+00:43:37,230 --> 00:43:41,990
+مجتمع ديمقراطي، فإذا كنا لسنا لدينا مجتمع
+
+645
+00:43:41,990 --> 00:43:44,170
+ديمقراطي، فإذا كنا لسنا لسنا لدينا مجتمع ديمقراطي،
+
+646
+00:43:44,170 --> 00:43:47,650
+فإذا
+
+647
+00:43:47,650 --> 00:43:50,550
+كنا لسنا لسنا لدينا مجتمع ديمقراطي، فإذا كنا لسنا
+
+648
+00:43:50,550 --> 00:43:50,550
+لسنا لسنا لسنا لسنا لسنا لسنا لسنا لسنا لسنا لسنا
+
+649
+00:43:50,550 --> 00:43:50,550
+لسنا لسنا لسنا لسنا لسنا لسنا لسنا لسنا لسنا لسنا
+
+650
+00:43:50,550 --> 00:43:52,960
+لسنا لسنا لسنا لسنا لسناوكانت اختارة من أعضاء
+
+651
+00:43:52,960 --> 00:43:57,340
+الناس، فبالعادة سيكون لدينا أشخاص ليسوا مدرسين
+
+652
+00:43:57,340 --> 00:44:00,540
+جيدا، ليسوا معرفة، ليسوا معرفة، ليسوا معرفة، ليسوا
+
+653
+00:44:00,540 --> 00:44:00,600
+معرفة، ليسوا معرفة، ليسوا معرفة، ليسوا معرفة،
+
+654
+00:44:00,600 --> 00:44:01,720
+ليسوا معرفة، ليسوا معرفة، ليسوا معرفة، ليسوا
+
+655
+00:44:01,720 --> 00:44:02,600
+معرفة، ليسوا معرفة، ليسوا معرفة، ليسوا معرفة،
+
+656
+00:44:02,600 --> 00:44:03,440
+ليسوا معرفة، ليسوا معرفة، ليسوا معرفة، ليسوا
+
+657
+00:44:03,440 --> 00:44:04,620
+معرفة، ليسوا معرفة، ليسوا معرفة، ليسوا معرفة،
+
+658
+00:44:04,620 --> 00:44:08,360
+ليسوا معرفة، ليسوا معرفة، ليسوا معرفة، ليسوا
+
+659
+00:44:08,360 --> 00:44:12,700
+معرفة، ليسوا معرفبعض المعلومات الدراسية هذا واحد
+
+660
+00:44:12,700 --> 00:44:15,620
+من المشكلة التي نتعامل معها أحيانًا مع شركة
+
+661
+00:44:15,620 --> 00:44:19,840
+Consumers Cooperative نعود إلى الصفحة السابقة في
+
+662
+00:44:19,840 --> 00:44:25,940
+التي ننظر إلى رولة الحكومة عملياتهم، عمليات
+
+663
+00:44:25,940 --> 00:44:30,500
+مديرهم،
+
+664
+00:44:30,500 --> 00:44:33,540
+مديراتهم، مديراتهم، مديراتهم، مديراتهم، مديراتهم،
+
+665
+00:44:33,540 --> 00:44:34,000
+مديراتهم، مديراتهم، مديراتهم، مديراتهم، مديراتهم،
+
+666
+00:44:34,000 --> 00:44:35,320
+مديراتهم، مديراتهم، مديراتهم، مديراتهم، مديراتهم،
+
+667
+00:44:35,320 --> 00:44:37,460
+مديراتهم، مديراتهم، مديراتهم، مديراتهم، مديراتهم،
+
+668
+00:44:37,460 --> 00:44:39,760
+مديراتهم، مديراتهم، مديراتهم، مدير
+
+669
+00:44:48,070 --> 00:44:51,170
+ماذا يمكنهم فعله؟ يستخدمون المال؟ نعم يستخدمون
+
+670
+00:44:51,170 --> 00:45:00,430
+المال؟ يستخدمون المال؟ يستخدمون المال؟ يستخدمون
+
+671
+00:45:00,430 --> 00:45:03,030
+المال؟ يستخدمون المال؟ يستخدمون المال؟ يستخدمون
+
+672
+00:45:03,030 --> 00:45:03,070
+المال؟ يستخدمون المال؟ يستخدمون المال؟ يستخدمون
+
+673
+00:45:03,070 --> 00:45:03,070
+المال؟ يستخدمون المال؟ يستخدمون المال؟ يستخدمون
+
+674
+00:45:03,070 --> 00:45:03,070
+المال؟ يستخدمون المال؟ يستخدمون المال؟ يستخدمون
+
+675
+00:45:03,070 --> 00:45:03,070
+المال؟ يستخدمون المال؟ يستخدمون المال؟ يستخدمون
+
+676
+00:45:03,070 --> 00:45:03,630
+المال؟ يستخدمون المال؟ يستخدمون المال؟ يستخدمون
+
+677
+00:45:03,630 --> 00:45:08,470
+المال؟ يستخدمون المال؟ يستخدمون المال؟ يستخدمون
+
+678
+00:45:08,470 --> 00:45:17,770
+المال؟ يستخدمهذه المالة المالية المالية المالية
+
+679
+00:45:17,770 --> 00:45:19,410
+المالية المالية المالية المالية المالية المالية
+
+680
+00:45:19,410 --> 00:45:19,590
+المالية المالية المالية المالية المالية المالية
+
+681
+00:45:19,590 --> 00:45:20,110
+المالية المالية المالية المالية المالية المالية
+
+682
+00:45:20,110 --> 00:45:20,490
+المالية المالية المالية المالية المالية المالية
+
+683
+00:45:20,490 --> 00:45:23,510
+المالية المالية المالية المالية المالية المالية
+
+684
+00:45:23,510 --> 00:45:29,090
+المالية المالية المالية المالية المالية المالية
+
+685
+00:45:29,090 --> 00:45:29,430
+المالية المالية المالية المالية المالية المالية
+
+686
+00:45:29,430 --> 00:45:29,430
+المالية المالية المالية المالية المالية المالية
+
+687
+00:45:29,430 --> 00:45:29,430
+المالية المالية المالية المالية المالية المالية
+
+688
+00:45:29,430 --> 00:45:29,450
+المالية المالية المالية المالية المالية المالية
+
+689
+00:45:29,450 --> 00:45:29,470
+المالية المالية المالية المالية المالية المالية
+
+690
+00:45:29,470 --> 00:45:31,070
+المالية المالية المالية المالية
+
+691
+00:45:40,870 --> 00:45:47,530
+شفافية transparent شفافية this mean .. this means
+
+692
+00:45:47,530 --> 00:45:50,950
+we don't have to have inspections we had many
+
+693
+00:45:50,950 --> 00:45:54,790
+times او as I said I focused many times on this
+
+694
+00:45:54,790 --> 00:45:58,710
+point inspections and I said that we don't have
+
+695
+00:45:58,710 --> 00:46:01,730
+inspection in all companies inspection is done by
+
+696
+00:46:01,730 --> 00:46:05,910
+somebody it's called in company inspector he or
+
+697
+00:46:05,910 --> 00:46:10,120
+she belong to the minister of economicsسوف يراقبوا
+
+698
+00:46:10,120 --> 00:46:13,560
+كل الشركات ماذا يفعلون، كم المال يفعلون، كم نسبة
+
+699
+00:46:13,560 --> 00:46:14,640
+يفعلون، كم نسبة يفعلون، كم نسبة يفعلون، كم نسبة
+
+700
+00:46:14,640 --> 00:46:15,080
+يفعلون، كم نسبة يفعلون، كم نسبة يفعلون، كم نسبة
+
+701
+00:46:15,080 --> 00:46:17,720
+يفعلون، كم نسبة يفعلون، كم نسبة يفعلون، كم نسبة
+
+702
+00:46:17,720 --> 00:46:18,420
+يفعلون، كم نسبة يفعلون، كم نسبة يفعلون، كم نسبة
+
+703
+00:46:18,420 --> 00:46:18,780
+يفعلون، كم نسبة يفعلون، كم نسبة يفعلون، كم نسبة
+
+704
+00:46:18,780 --> 00:46:24,280
+يفعلون، كم نسبة يفعلون، كم نسبة يفعلون، كم نسبة
+
+705
+00:46:24,280 --> 00:46:37,840
+يفعلون،
+
+706
+00:46:37,840 --> 00:46:44,910
+كم نسبة يكيف ستتعامل مع المال؟ لن تتعامل معه؟ كشخص
+
+707
+00:46:44,910 --> 00:46:49,430
+في شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+708
+00:46:49,430 --> 00:46:49,970
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+709
+00:46:49,970 --> 00:46:50,010
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+710
+00:46:50,010 --> 00:46:50,010
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+711
+00:46:50,010 --> 00:46:50,170
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+712
+00:46:50,170 --> 00:46:52,910
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+713
+00:46:52,910 --> 00:46:57,370
+شركة شركة شركة شركة شركة
+
+714
+00:46:57,370 --> 00:47:09,750
+شركة شرك
+
+715
+00:47:09,780 --> 00:47:15,300
+ثم لا يوجد حاجة لتحقيق التجارب أو تحقيق التجارب أو
+
+716
+00:47:15,300 --> 00:47:17,280
+تحقيق التجارب أو تحقيق التجارب أو تحقيق التجارب أو
+
+717
+00:47:17,280 --> 00:47:17,540
+تحقيق التجارب أو تحقيق التجارب أو تحقيق التجارب أو
+
+718
+00:47:17,540 --> 00:47:18,160
+تحقيق التجارب أو تحقيق التجارب أو تحقيق التجارب أو
+
+719
+00:47:18,160 --> 00:47:18,860
+تحقيق التجارب أو تحقيق التجارب أو تحقيق التجارب أو
+
+720
+00:47:18,860 --> 00:47:20,780
+تحقيق التجارب أو تحقيق التجارب أو تحقيق التجارب أو
+
+721
+00:47:20,780 --> 00:47:21,720
+تحقيق التجارب أو تحقيق التجارب أو تحقيق التجارب أو
+
+722
+00:47:21,720 --> 00:47:34,060
+تحقيق التجارب أو تحقيق التجارب أو تحقيق التجارب أو
+
+723
+00:47:34,060 --> 00:47:37,400
+تحقيق التجار
+
+724
+00:48:02,770 --> 00:48:08,210
+because they don't gain as income or they invested
+
+725
+00:48:08,210 --> 00:48:14,880
+for the company and for the societyOkay it's not
+
+726
+00:48:14,880 --> 00:48:19,700
+it's not some schoolers say some claim that this
+
+727
+00:48:19,700 --> 00:48:23,940
+is surplus surplus extra amount of money payment
+
+728
+00:48:23,940 --> 00:48:27,280
+and even we return it to the owner the consumer
+
+729
+00:48:27,280 --> 00:48:32,820
+should be taxed should be taxed why because this
+
+730
+00:48:32,820 --> 00:48:36,840
+is equal it's equal over payment but equal gain
+
+731
+00:48:36,840 --> 00:48:42,040
+it's equal to the profitلذلك حتى لو لم نسميها
+
+732
+00:48:42,040 --> 00:48:46,740
+مربوطة ولم نقول إنها مربوطة ولكنها مثل مربوطة ثم
+
+733
+00:48:46,740 --> 00:48:52,220
+يجب أن ندفع دفع أخرين قالوا لا هذا ليس دفع يجب أن
+
+734
+00:48:52,220 --> 00:48:56,300
+ندفع دفع هذا ليس مربوطة ثم يجب أن ندفع دفع أخرين
+
+735
+00:48:56,300 --> 00:49:01,800
+قالوا ان مجتمع مجتمع لا يدفع مربوطة هذا ليس مربوطة
+
+736
+00:49:01,800 --> 00:49:07,820
+بمعنى تقليد تقليد هذا ليس مربوطةهو تجارب اضافية
+
+737
+00:49:07,820 --> 00:49:09,560
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+738
+00:49:09,560 --> 00:49:12,140
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+739
+00:49:12,140 --> 00:49:14,800
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+740
+00:49:14,800 --> 00:49:15,300
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+741
+00:49:15,300 --> 00:49:15,860
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+742
+00:49:15,860 --> 00:49:21,960
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+743
+00:49:21,960 --> 00:49:32,760
+تجارب تجارب تجارب تجارب تجارب تج
+
+744
+00:49:32,900 --> 00:49:37,000
+والخيارات من كل البلد لتقرر بالضبط ماذا تفعل معها
+
+745
+00:49:37,000 --> 00:49:46,800
+اخر نقطة في هذا البرنامج هو مركز الدراسة مركز
+
+746
+00:49:46,800 --> 00:49:50,740
+الدراسة، هذا النقطة، هذه الشركة كانت مركز الدراسة
+
+747
+00:49:50,740 --> 00:49:57,410
+من العديد من الوزياءبعض المجلدات العامة و العديد
+
+748
+00:49:57,410 --> 00:49:57,410
+من المدرسات العامة و العديد من المدرسات العامة و
+
+749
+00:49:57,410 --> 00:49:59,630
+العديد من المدرسات العامة و العديد من المدرسات
+
+750
+00:49:59,630 --> 00:50:02,450
+العامة و العديد من المدرسات العامة و العديد من
+
+751
+00:50:02,450 --> 00:50:03,390
+المدرسات العامة و العديد من المدرسات العامة و
+
+752
+00:50:03,390 --> 00:50:03,590
+العديد من المدرسات العامة و العديد من المدرسات
+
+753
+00:50:03,590 --> 00:50:03,850
+العامة و العديد من المدرسات العامة و العديد من
+
+754
+00:50:03,850 --> 00:50:04,550
+المدرسات العامة و العديد من المدرسات العامة و
+
+755
+00:50:04,550 --> 00:50:07,330
+العديد من المدرسات العامة و العديد من المدرسات
+
+756
+00:50:07,330 --> 00:50:12,950
+العامة و العديد من المدرسات العامة و العديد من
+
+757
+00:50:12,950 --> 00:50:23,050
+المدرسات العامة و العديد
+
+758
+00:50:23,050 --> 00:50:24,430
+من
+
+759
+00:50:26,700 --> 00:50:30,700
+advocating such organizational forms claiming a
+
+760
+00:50:30,700 --> 00:50:34,040
+broad set of benefits including .. these benefits
+
+761
+00:50:34,040 --> 00:50:37,560
+what we have what kind of benefits we haveeconomic
+
+762
+00:50:37,560 --> 00:50:43,280
+democracy and justice, transparency, greater
+
+763
+00:50:43,280 --> 00:50:47,000
+product purity and financial benefit for consumers
+
+764
+00:50:47,000 --> 00:50:49,500
+so it's not only about the gain and equality and
+
+765
+00:50:49,500 --> 00:50:51,320
+less amount of money, we do have as well
+
+766
+00:50:51,320 --> 00:50:53,920
+democracy, we have election, we have people who
+
+767
+00:50:53,920 --> 00:50:56,660
+can manage, we have people who can vote, it's a
+
+768
+00:50:56,660 --> 00:51:01,180
+system of justiceالنقل اللي يجب أن نتخلصه في هذا
+
+769
+00:51:01,180 --> 00:51:04,560
+النوع من الشبكات هذا هو السبب في الكثير من الناس
+
+770
+00:51:04,560 --> 00:51:07,600
+اليوم يفكرون في هذا الموضوع حتى لو لم يكن لدينا
+
+771
+00:51:07,600 --> 00:51:11,100
+نفسنا فعلا لم نكن لدينا نفسنا انظروا في غزا كم
+
+772
+00:51:11,100 --> 00:51:14,960
+شركة شركة تعمل معاها لدينا ربما لدينا واحدة او
+
+773
+00:51:14,960 --> 00:51:19,260
+اثنين ربما ليس كذلك ولكن هناك شيء مفقود هنا في
+
+774
+00:51:19,260 --> 00:51:26,900
+مجالنا على الرغم من مركز التخيل على هذاconsumer
+
+775
+00:51:26,900 --> 00:51:29,280
+cooperative as a business entity but in a
+
+776
+00:51:29,280 --> 00:51:32,280
+practical life we don't have it much it's not much
+
+777
+00:51:32,280 --> 00:51:36,080
+implemented then I guess that for people they have
+
+778
+00:51:36,080 --> 00:51:39,960
+to learn it they have to take the benefit of this
+
+779
+00:51:39,960 --> 00:51:46,120
+type and apply it what do you think you do
+
+780
+00:51:46,120 --> 00:51:56,740
+you think it's a good idea do you yes or nono
+
+781
+00:51:56,740 --> 00:52:06,760
+opinion؟ abstain؟ متحفظين يعني؟ اقولنا؟
+
+782
+00:52:06,760 --> 00:52:11,720
+انا I think it's a good idea وش هو ده طبت وش هو
+
+783
+00:52:11,720 --> 00:52:12,840
+implement in our life
+
+784
+00:52:16,680 --> 00:52:19,380
+لنأخذ فقط صفحة واحدة هنا صفحة واحدة صفحة واحدة
+
+785
+00:52:19,380 --> 00:52:22,640
+اضافية صفحة ولكن قبل أن نذهب إلى هذه الصفحة اريد
+
+786
+00:52:22,640 --> 00:52:26,080
+مرة أخرى ان اتفاق عن ما لدينا حتى الآن اعني لـ
+
+787
+00:52:26,080 --> 00:52:30,880
+Consumer Cooperative لدينا حوالي 6 صفحة في واحدة
+
+788
+00:52:30,880 --> 00:52:38,500
+شركة و اعتقد ان يجب أن نركز على هذا الوقت مرة أخرى
+
+789
+00:52:38,500 --> 00:52:41,740
+و اعتقد ان يجب أن تقرأ مرة أخرى في المنزل و تدرس
+
+790
+00:52:41,740 --> 00:52:45,800
+بطريقة .. انتظر الكتاب و انتظر الصفحة و انتظرlike
+
+791
+00:52:45,800 --> 00:52:47,700
+if you want to follow me here on the slides that's
+
+792
+00:52:47,700 --> 00:52:52,140
+good and you have to look at the points one by one
+
+793
+00:52:52,140 --> 00:52:55,060
+I think the information we have not difficult but
+
+794
+00:52:55,060 --> 00:52:57,140
+what you need to do just to read them again and
+
+795
+00:52:57,140 --> 00:53:00,920
+again and there's some new words and terms some
+
+796
+00:53:00,920 --> 00:53:03,560
+new legal terms you have to study them and to
+
+797
+00:53:03,560 --> 00:53:07,340
+understand exactly what they mean and then if you
+
+798
+00:53:07,340 --> 00:53:11,140
+have any difficult term or word you can come back
+
+799
+00:53:11,140 --> 00:53:15,100
+to me I will translate it to youسنأخذ هذه الصفحة
+
+800
+00:53:15,100 --> 00:53:18,920
+partnership لأن في المرة القادمة عندما نأتي للعامة
+
+801
+00:53:18,920 --> 00:53:22,880
+هنا لدينا ثلاثة أشكال من partnership في الحقيقة
+
+802
+00:53:22,880 --> 00:53:29,500
+لدينا أربع أشكال partnership هذا نسميه partnership
+
+803
+00:53:29,500 --> 00:53:33,320
+عام عام عندما نرى أن هذا هو الرقم أول partnership
+
+804
+00:53:33,320 --> 00:53:38,010
+عام عام بعد ذلك لدينا partner limitedو بعدها لعبات
+
+805
+00:53:38,010 --> 00:53:42,510
+محددة و بعدها لعبات محددة و بعدها لعبات محددة و
+
+806
+00:53:42,510 --> 00:53:45,110
+بعدها لعبات محددة و بعدها لعبات محددة و بعدها
+
+807
+00:53:45,110 --> 00:53:49,250
+لعبات محددة و بعدها لعبات محددة و بعدها لعبات
+
+808
+00:53:49,250 --> 00:53:50,370
+محددة و بعدها لعبات محددة و بعدها لعبات محددة و
+
+809
+00:53:50,370 --> 00:53:50,370
+بعدها لعبات محددة و بعدها لعبات محددة و بعدها
+
+810
+00:53:50,370 --> 00:53:50,370
+لعبات محددة و بعدها لعبات محددة و بعدها لعبات
+
+811
+00:53:50,370 --> 00:53:50,370
+محددة و بعدها لعبات محددة و بعدها لعبات محددة و
+
+812
+00:53:50,370 --> 00:53:53,810
+بعدها لعبات محددة و بعدها لعبات محددة و بعدها
+
+813
+00:53:53,810 --> 00:53:58,890
+لعبات محددة و بعدها لعبات محددة و بعدها لعبات
+
+814
+00:53:58,890 --> 00:54:06,530
+محددة و بعدها لبشكل عام و نسميها في بعض الأحيان جي
+
+815
+00:54:06,530 --> 00:54:11,150
+بي جنرال partnership في هذه اللحظة هنا هذه اللحظة
+
+816
+00:54:11,150 --> 00:54:16,170
+هي شركة عامة نحن لدينا شركات نحن لدينا بعض الشركات
+
+817
+00:54:16,170 --> 00:54:21,110
+نحن
+
+818
+00:54:21,110 --> 00:54:28,370
+لدينا شركات و نحن لدينا مصادر نحن لا نسميهم شركات
+
+819
+00:54:28,370 --> 00:54:34,250
+مصادر نسميهم partnerالشركات ليست شركات مستخدمين بل
+
+820
+00:54:34,250 --> 00:54:40,150
+شركات مستخدمين بل شركات مستخدمين
+
+821
+00:54:41,170 --> 00:54:44,930
+أو تخسر بعض الوقت انت لا تجعل نفسك نفسك نفسك نفسك
+
+822
+00:54:44,930 --> 00:54:45,690
+نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك
+
+823
+00:54:45,690 --> 00:54:46,490
+نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك
+
+824
+00:54:46,490 --> 00:54:48,730
+نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك
+
+825
+00:54:48,730 --> 00:54:49,990
+نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك
+
+826
+00:54:49,990 --> 00:54:56,590
+نفسك نفسك نفسك نفسك
+
+827
+00:55:12,190 --> 00:55:17,610
+Till fifty They might be friends Most likely
+
+828
+00:55:17,610 --> 00:55:21,930
+family members People who trust each other Like
+
+829
+00:55:21,930 --> 00:55:23,610
+you in the class here, you know each other very
+
+830
+00:55:23,610 --> 00:55:27,430
+well You might have a partnership You might invest
+
+831
+00:55:27,430 --> 00:55:31,550
+your money in something like this Because you know
+
+832
+00:55:31,550 --> 00:55:34,170
+each other and you have the trust And you can look
+
+833
+00:55:34,170 --> 00:55:39,220
+after your moneyبعد مالك ولكن هنا و الكثير من
+
+834
+00:55:39,220 --> 00:55:42,780
+الناس يذهبون لهذا الوقت لأنه شركة صغيرة لا
+
+835
+00:55:42,780 --> 00:55:46,220
+تستخدمون الكثير من المال ، تعرفون بعضكما جيدًا
+
+836
+00:55:46,220 --> 00:55:49,780
+جدًا تثقون بعضكما جدًا و حتى التجارب هنا لسنا ندفع
+
+837
+00:55:49,780 --> 00:55:54,380
+الكثير من التجارب ، ندفعها مرة وليس مثل شركة تجارب
+
+838
+00:55:54,380 --> 00:55:56,300
+مدفعة مدفعة مدفعة مدفعة مدفعة مدفعة مدفعة مدفعة
+
+839
+00:55:56,300 --> 00:55:56,680
+مدفعة مدفعة مدفعة مدفعة مدفعة مدفعة مدفعة مدفعة
+
+840
+00:55:56,680 --> 00:55:58,380
+مدفعة مدفعة مدفعة مدفعة مدفعة مدفعة مدفعة مدفعة
+
+841
+00:55:58,380 --> 00:56:04,500
+مدفعة مدفعة
+
+842
+00:56:04,500 --> 00:56:11,180
+مدفولكن في شركات قيمة قيمة قيمة أو شركات قيمة أو
+
+843
+00:56:11,180 --> 00:56:12,520
+شركات قيمة أو شركات قيمة أو شركات قيمة أو شركات
+
+844
+00:56:12,520 --> 00:56:12,540
+قيمة أو شركات قيمة أو شركات قيمة أو شركات قيمة أو
+
+845
+00:56:12,540 --> 00:56:12,960
+شركات قيمة أو شركات قيمة أو شركات قيمة أو شركات
+
+846
+00:56:12,960 --> 00:56:15,720
+قيمة أو شركات قيمة أو شركات قيمة أو شركات قيمة أو
+
+847
+00:56:15,720 --> 00:56:16,160
+شركات قيمة أو شركات قيمة أو شركات قيمة أو شركات
+
+848
+00:56:16,160 --> 00:56:16,160
+قيمة أو شركات قيمة أو شركات قيمة أو شركات قيمة أو
+
+849
+00:56:16,160 --> 00:56:16,840
+شركات قيمة أو شركات قيمة أو شركات قيمة أو شركات
+
+850
+00:56:16,840 --> 00:56:22,920
+قيمة أو شركات قيمة أو شركات قيمة أو شركات قيمة أو
+
+851
+00:56:22,920 --> 00:56:26,590
+شركات قيمإذا كانت المشاركة تخسر المال، فهذا يعني
+
+852
+00:56:26,590 --> 00:56:31,730
+خسارة المشاركين أيضًا، فهذا يعني أن المرحلة عالية،
+
+853
+00:56:31,730 --> 00:56:35,290
+المرحلة عالية، أنا لن أخسر فقط المال اللي بقيته
+
+854
+00:56:35,290 --> 00:56:37,890
+كمشاركة، ربما أخسر حتى مالي شخصيي
+
+855
+00:56:40,990 --> 00:56:44,190
+هو ليس فقط قيمة المال اللي نستخدمه لأننا لدينا
+
+856
+00:56:44,190 --> 00:56:48,430
+قيمة محددة فقط لكي نفقد المال اللي نستخدمه ولكن في
+
+857
+00:56:48,430 --> 00:56:51,550
+هذه الوقت نستطيع أن نفقد أكتر من هذا الوقت إذا كنت
+
+858
+00:56:51,550 --> 00:56:55,810
+أستخدم 10 ألف رمضان ربما أفقدهم و ربما أفقد أيضًا
+
+859
+00:56:55,810 --> 00:57:00,190
+مالي الخاص بي و سننظر إلى هذا عندما نحصل على
+
+860
+00:57:00,190 --> 00:57:06,410
+مغامرة مغامرة سننظرفي هذه الحالة كم مال يمكنك أن
+
+861
+00:57:06,410 --> 00:57:09,470
+تخسر ما يمكننا أن نأخذه كم يمكننا أن نبيههم كم
+
+862
+00:57:09,470 --> 00:57:13,390
+يمكننا أن نقلهم بين المستخدمين بشكل عام كما يمكنك
+
+863
+00:57:13,390 --> 00:57:17,370
+أن ترى هنا في المرة القادمة سننظر إلى أشياء أخرى
+
+864
+00:57:17,370 --> 00:57:23,210
+من المشاركات وسترى الفرق بينهم الفرق الرئيسي بين
+
+865
+00:57:23,210 --> 00:57:28,850
+المشاركات هي بسبب المساعدة لأن هذه المرة لديها
+
+866
+00:57:30,980 --> 00:57:33,720
+ولكن في المرات القليل من الوقت ستكون لديك بعض
+
+867
+00:57:33,720 --> 00:57:38,860
+الوقت مرتبط و بعض الوقت مرتبط، مرتبط و مرتبط و
+
+868
+00:57:38,860 --> 00:57:39,660
+مرتبط و مرتبط و مرتبط و مرتبط و مرتبط و مرتبط و
+
+869
+00:57:39,660 --> 00:57:39,860
+مرتبط و مرتبط و مرتبط و مرتبط و مرتبط و مرتبط و
+
+870
+00:57:39,860 --> 00:57:42,900
+مرتبط و مرتبط و مرتبط و مرتبط و مرتبط و مرتبط و
+
+871
+00:57:42,900 --> 00:57:43,000
+مرتبط و مرتبط و مرتبط و مرتبط و مرتبط و مرتبط و
+
+872
+00:57:43,000 --> 00:57:43,000
+مرتبط و مرتبط و مرتبط و مرتبط و مرتبط و مرتبط و
+
+873
+00:57:43,000 --> 00:57:46,880
+مرتبط و مرتبط و مرتبط و مرتبط و
+
+874
+00:57:46,880 --> 00:57:51,380
+مرتبط و
+
+875
+00:57:52,100 --> 00:57:55,660
+هذا هو الوقت الرئيسي، لدينا وقت طويل و لدينا وقت
+
+876
+00:57:55,660 --> 00:57:57,160
+طويل و لدينا وقت طويل و لدينا وقت طويل و لدينا وقت
+
+877
+00:57:57,160 --> 00:57:58,720
+طويل و لدينا وقت طويل و لدينا وقت طويل و لدينا و
+
+878
+00:57:58,720 --> 00:58:02,340
+لدينا و لدينا و لدينا و لدينا و لدينا و لدينا و
+
+879
+00:58:02,340 --> 00:58:02,400
+لدينا و لدينا و لدينا و لدينا و لدينا و لدينا و
+
+880
+00:58:02,400 --> 00:58:03,580
+لدينا و لدينا و لدينا و لدينا و لدينا و لدينا و
+
+881
+00:58:03,580 --> 00:58:04,100
+لدينا و لدينا و لدينا و لدينا و لدينا و لدينا و
+
+882
+00:58:04,100 --> 00:58:04,480
+لدينا و لدينا و لدينا و لدينا و لدينا و لدينا و
+
+883
+00:58:04,480 --> 00:58:13,670
+لدينا و لدينا و لدينا و لدينا و لدينا و لدينا و لو
+
+884
+00:58:13,670 --> 00:58:18,590
+LPs Limited Partners باستخدام المثال اللي لدينا
+
+885
+00:58:18,590 --> 00:58:21,130
+اليوم ستكون هناك الكثير من المثال للمرة القادمة
+
+886
+00:58:21,130 --> 00:58:25,610
+ويجب أن نكون حذرين عن كيف نختار بين هذه الطبيعيات
+
+887
+00:58:25,610 --> 00:58:31,420
+القديمة أريدك أن تنظر إلى هذه الصفحاتand the book
+
+888
+00:58:31,420 --> 00:58:35,180
+and try to understand other types of partnership
+
+889
+00:58:35,180 --> 00:58:38,360
+because it's not going to be easy sometimes to
+
+890
+00:58:38,360 --> 00:58:40,740
+distinguish but we have to look at them carefully
+
+891
+00:58:40,740 --> 00:58:43,500
+I want you to review at home what we have to learn
+
+892
+00:58:43,500 --> 00:58:47,100
+what we have to learn well and I want you to be
+
+893
+00:58:47,100 --> 00:58:50,380
+ready for the next class because I know that we
+
+894
+00:58:50,380 --> 00:58:52,740
+have many details and we have to pass this
+
+895
+00:58:52,740 --> 00:58:55,890
+semester welland we have to focus on this chapter
+
+896
+00:58:55,890 --> 00:58:57,970
+because this chapter we have in companies and
+
+897
+00:58:57,970 --> 00:59:01,090
+corporations is the longest chapter it's the
+
+898
+00:59:01,090 --> 00:59:05,130
+longest and at the same time it can be sometimes
+
+899
+00:59:05,130 --> 00:59:08,170
+difficult in some points because we can mix
+
+900
+00:59:08,170 --> 00:59:13,350
+between two more than two entities meaning I want
+
+901
+00:59:13,350 --> 00:59:15,230
+you just to focus at home and to study as much as
+
+902
+00:59:15,230 --> 00:59:17,890
+you can and if you have any question at any time I
+
+903
+00:59:17,890 --> 00:59:20,450
+will be ready to answer that okay thanks very much
+
+904
+00:59:20,450 --> 00:59:22,190
+for your time and I'll see you Tuesday
+
diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/ZfTOFPRicdM_raw.json b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/ZfTOFPRicdM_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..1211f04693060d8eeef8a92cae5352ce1a0282e8
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/ZfTOFPRicdM_raw.json
@@ -0,0 +1 @@
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A لديها قرأة. 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{"start": 3826.43, "end": 3826.45, "word": " مطلوب", "probability": 0.9801025390625}, {"start": 3826.45, "end": 3826.45, "word": " من", "probability": 0.986328125}, {"start": 3826.45, "end": 3826.45, "word": " القوة", "probability": 0.9723307291666666}, {"start": 3826.45, "end": 3826.45, "word": " شرط", "probability": 0.7657063802083334}, {"start": 3826.45, "end": 3826.59, "word": " مطلوب", "probability": 0.9849853515625}, {"start": 3826.59, "end": 3826.59, "word": " من", "probability": 0.9931640625}, {"start": 3826.59, "end": 3826.81, "word": " القوة", "probability": 0.97314453125}, {"start": 3826.81, "end": 3826.81, "word": " شرط", "probability": 0.7958170572916666}, {"start": 3826.81, "end": 3826.81, "word": " مطلوب", "probability": 0.9869384765625}, {"start": 3826.81, "end": 3826.81, "word": " من", "probability": 0.99560546875}, {"start": 3826.81, "end": 3826.89, "word": " القوة", "probability": 0.97314453125}, {"start": 3826.89, "end": 3827.83, "word": " شرط", "probability": 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385520, "start": 3836.68, "end": 3855.2, "text": "يجب أن ننظر إلى القصة الرابعة وهي سالة قرار الله 1979 في الولايات المتحدة القصة هذه ستأخذ فقط أسبوع أو أسبوع اثنان لا أعرف بالضبط، يجب أن نرى كيف تعمل، شكرا لوقتك، ولكننا سنحصل على طلاب سيقوم بتقديره لخمس دقائق", "tokens": [1829, 7435, 3555, 14739, 8717, 1863, 19913, 2288, 30731, 25062, 9381, 3660, 34892, 16758, 27884, 37037, 1829, 8608, 6027, 3660, 12174, 2288, 9640, 21984, 30595, 8978, 2423, 12610, 47302, 9307, 9673, 2655, 24401, 3660, 25062, 9381, 3660, 29538, 8608, 2655, 10721, 9778, 8848, 6156, 47432, 5551, 35457, 45367, 34051, 5551, 35457, 45367, 1975, 12984, 1863, 7649, 20193, 5551, 3615, 28480, 20666, 11242, 3555, 9566, 12399, 7251, 7435, 3555, 14739, 8717, 2288, 7578, 9122, 33911, 6055, 25957, 1211, 12399, 13412, 4117, 23557, 5296, 30543, 2655, 4117, 12399, 35525, 19452, 8315, 8608, 1863, 5016, 36520, 15844, 23032, 15040, 3555, 8608, 1829, 4587, 20498, 39894, 28543, 13546, 3224, 5296, 9778, 2304, 3794, 11778, 4587, 16373, 4587], "avg_logprob": -0.5942982424769485, "compression_ratio": 1.6981981981981982, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 3836.68, "end": 3837.06, "word": "يجب", "probability": 0.6133015950520834}, {"start": 3837.06, "end": 3837.12, "word": " أن", "probability": 0.55419921875}, {"start": 3837.12, "end": 3837.3, "word": " ننظر", "probability": 0.8603515625}, {"start": 3837.3, "end": 3837.48, "word": " إلى", "probability": 0.8486328125}, {"start": 3837.48, "end": 3837.82, "word": " القصة", "probability": 0.4704182942708333}, {"start": 3837.82, "end": 3838.2, "word": " الرابعة", "probability": 0.6830240885416666}, {"start": 3838.2, "end": 3839.58, "word": " وهي", "probability": 0.465576171875}, {"start": 3839.58, "end": 3840.92, "word": " سالة", "probability": 0.4123738606770833}, {"start": 3840.92, "end": 3841.7, "word": " قرار", "probability": 0.2837117513020833}, {"start": 3841.7, "end": 3841.7, "word": " الله", "probability": 0.83349609375}, {"start": 3841.7, "end": 3843.08, "word": " 1979", "probability": 0.1947021484375}, {"start": 3843.08, "end": 3843.66, "word": " في", "probability": 0.76171875}, {"start": 3843.66, "end": 3844.1, "word": " الولايات", "probability": 0.69683837890625}, {"start": 3844.1, "end": 3844.1, "word": " المتحدة", "probability": 0.855224609375}, {"start": 3844.1, "end": 3845.32, "word": " القصة", "probability": 0.7137451171875}, {"start": 3845.32, "end": 3845.34, "word": " هذه", "probability": 0.264892578125}, {"start": 3845.34, "end": 3845.66, "word": " ستأخذ", "probability": 0.6833251953125}, {"start": 3845.66, "end": 3845.86, "word": " فقط", "probability": 0.6748046875}, {"start": 3845.86, "end": 3846.52, "word": " أسبوع", "probability": 0.8196614583333334}, {"start": 3846.52, "end": 3846.72, "word": " أو", "probability": 0.53662109375}, {"start": 3846.72, "end": 3846.98, "word": " أسبوع", "probability": 0.6410725911458334}, {"start": 3846.98, "end": 3847.16, "word": " اثنان", "probability": 0.55078125}, {"start": 3847.16, "end": 3847.46, "word": " لا", "probability": 0.215087890625}, {"start": 3847.46, "end": 3847.62, "word": " أعرف", "probability": 0.9052734375}, {"start": 3847.62, "end": 3848.4, "word": " بالضبط،", "probability": 0.70947265625}, {"start": 3848.4, "end": 3848.58, "word": " يجب", "probability": 0.8863932291666666}, {"start": 3848.58, "end": 3848.66, "word": " أن", "probability": 0.9013671875}, {"start": 3848.66, "end": 3848.94, "word": " نرى", "probability": 0.85888671875}, {"start": 3848.94, "end": 3849.42, "word": " كيف", "probability": 0.865478515625}, {"start": 3849.42, "end": 3850.0, "word": " تعمل،", "probability": 0.4503173828125}, {"start": 3850.0, "end": 3850.88, "word": " شكرا", "probability": 0.89501953125}, {"start": 3850.88, "end": 3851.68, "word": " لوقتك،", "probability": 0.66904296875}, {"start": 3851.68, "end": 3851.88, "word": " ولكننا", "probability": 0.583984375}, {"start": 3851.88, "end": 3852.16, "word": " سنحصل", "probability": 0.66326904296875}, {"start": 3852.16, "end": 3852.18, "word": " على", "probability": 0.841796875}, {"start": 3852.18, "end": 3852.56, "word": " طلاب", "probability": 0.64599609375}, {"start": 3852.56, "end": 3853.7, "word": " سيقوم", "probability": 0.49462890625}, {"start": 3853.7, "end": 3854.38, "word": " بتقديره", "probability": 0.278656005859375}, {"start": 3854.38, "end": 3854.82, "word": " لخمس", "probability": 0.69793701171875}, {"start": 3854.82, "end": 3855.2, "word": " دقائق", "probability": 0.71905517578125}], "temperature": 1.0}, {"id": 144, "seek": 388685, "start": 3857.81, "end": 3886.85, "text": "Good afternoon. Today I will talk about illegal contracts. Let's begin with the definition of illegal contracts. Contracts whose formation object or performance is so iniquitous against the law of the land or contrary to public policy that no court will interrogation or enforce it. Technically it's no contract in situation where two wrong doors", "tokens": [14649, 6499, 13, 2692, 286, 486, 751, 466, 11905, 13952, 13, 961, 311, 1841, 365, 264, 7123, 295, 11905, 13952, 13, 44659, 82, 6104, 11723, 2657, 420, 3389, 307, 370, 294, 3221, 39831, 1970, 264, 2101, 295, 264, 2117, 420, 19506, 281, 1908, 3897, 300, 572, 4753, 486, 24871, 399, 420, 24825, 309, 13, 42494, 309, 311, 572, 4364, 294, 2590, 689, 732, 2085, 8077], "avg_logprob": -0.2466856078668074, "compression_ratio": 1.6398104265402844, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 3857.81, "end": 3858.05, "word": "Good", "probability": 0.1358642578125}, {"start": 3858.05, "end": 3858.45, "word": " afternoon.", "probability": 0.8173828125}, {"start": 3859.07, "end": 3859.37, "word": " Today", "probability": 0.67236328125}, {"start": 3859.37, "end": 3860.11, "word": " I", "probability": 0.84619140625}, {"start": 3860.11, "end": 3860.23, "word": " will", "probability": 0.818359375}, {"start": 3860.23, "end": 3860.55, "word": " talk", "probability": 0.90185546875}, {"start": 3860.55, "end": 3861.13, "word": " about", "probability": 0.93310546875}, {"start": 3861.13, "end": 3861.43, "word": " illegal", "probability": 0.81640625}, {"start": 3861.43, "end": 3862.11, "word": " contracts.", "probability": 0.84033203125}, {"start": 3862.85, "end": 3863.25, "word": " Let's", "probability": 0.846923828125}, {"start": 3863.25, "end": 3863.43, "word": " begin", "probability": 0.8193359375}, {"start": 3863.43, "end": 3863.61, "word": " with", "probability": 0.89453125}, {"start": 3863.61, "end": 3863.73, "word": " the", "probability": 0.892578125}, {"start": 3863.73, "end": 3864.83, "word": " definition", "probability": 0.90380859375}, {"start": 3864.83, "end": 3865.45, "word": " of", "probability": 0.974609375}, {"start": 3865.45, "end": 3865.81, "word": " illegal", "probability": 0.8857421875}, {"start": 3865.81, "end": 3866.49, "word": " contracts.", "probability": 0.77099609375}, {"start": 3866.63, "end": 3867.11, "word": " Contracts", "probability": 0.6630859375}, {"start": 3867.11, "end": 3867.29, "word": " whose", "probability": 0.81396484375}, {"start": 3867.29, "end": 3867.73, "word": " formation", "probability": 0.93505859375}, {"start": 3867.73, "end": 3868.33, "word": " object", "probability": 0.424560546875}, {"start": 3868.33, "end": 3868.73, "word": " or", "probability": 0.94140625}, {"start": 3868.73, "end": 3869.41, "word": " performance", "probability": 0.9326171875}, {"start": 3869.41, "end": 3869.73, "word": " is", "probability": 0.95849609375}, {"start": 3869.73, "end": 3870.03, "word": " so", "probability": 0.9521484375}, {"start": 3870.03, "end": 3871.27, "word": " iniquitous", "probability": 0.8096516927083334}, {"start": 3871.27, "end": 3872.41, "word": " against", "probability": 0.94140625}, {"start": 3872.41, "end": 3872.75, "word": " the", "probability": 0.923828125}, {"start": 3872.75, "end": 3873.05, "word": " law", "probability": 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{"start": 3879.49, "end": 3880.57, "word": " interrogation", "probability": 0.44195556640625}, {"start": 3880.57, "end": 3880.87, "word": " or", "probability": 0.95703125}, {"start": 3880.87, "end": 3881.51, "word": " enforce", "probability": 0.8486328125}, {"start": 3881.51, "end": 3881.85, "word": " it.", "probability": 0.95751953125}, {"start": 3882.27, "end": 3882.63, "word": " Technically", "probability": 0.87109375}, {"start": 3882.63, "end": 3883.27, "word": " it's", "probability": 0.672607421875}, {"start": 3883.27, "end": 3883.61, "word": " no", "probability": 0.7080078125}, {"start": 3883.61, "end": 3884.15, "word": " contract", "probability": 0.8828125}, {"start": 3884.15, "end": 3884.75, "word": " in", "probability": 0.923828125}, {"start": 3884.75, "end": 3885.21, "word": " situation", "probability": 0.6416015625}, {"start": 3885.21, "end": 3885.49, "word": " where", "probability": 0.93359375}, {"start": 3885.49, "end": 3885.73, "word": " two", "probability": 0.90478515625}, {"start": 3885.73, "end": 3886.19, "word": " wrong", "probability": 0.892578125}, {"start": 3886.19, "end": 3886.85, "word": " doors", "probability": 0.94677734375}], "temperature": 1.0}, {"id": 145, "seek": 389853, "start": 3887.29, "end": 3898.53, "text": "enter into illegal contracts and one of them takes advantage of the other, law normally will not increase to rectify the situation", "tokens": [14278, 666, 11905, 13952, 293, 472, 295, 552, 2516, 5002, 295, 264, 661, 11, 2101, 5646, 486, 406, 3488, 281, 11048, 2505, 264, 2590], "avg_logprob": -0.36343749046325685, "compression_ratio": 1.3, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 3887.29, "end": 3887.71, "word": "enter", "probability": 0.034027099609375}, {"start": 3887.71, "end": 3888.09, "word": " into", "probability": 0.84765625}, {"start": 3888.09, "end": 3888.55, "word": " illegal", "probability": 0.39111328125}, {"start": 3888.55, "end": 3889.23, "word": " contracts", "probability": 0.8173828125}, {"start": 3889.23, "end": 3889.55, "word": " and", "probability": 0.72314453125}, {"start": 3889.55, "end": 3889.75, "word": " one", "probability": 0.9423828125}, {"start": 3889.75, "end": 3889.93, "word": " of", "probability": 0.97314453125}, {"start": 3889.93, "end": 3890.21, "word": " them", "probability": 0.91943359375}, {"start": 3890.21, "end": 3890.73, "word": " takes", "probability": 0.71923828125}, {"start": 3890.73, "end": 3891.19, "word": " advantage", "probability": 0.6982421875}, {"start": 3891.19, "end": 3891.51, "word": " of", "probability": 0.97021484375}, {"start": 3891.51, "end": 3891.73, "word": " the", "probability": 0.86181640625}, {"start": 3891.73, "end": 3892.13, "word": " other,", "probability": 0.89111328125}, {"start": 3893.11, "end": 3893.27, "word": " law", "probability": 0.5048828125}, {"start": 3893.27, "end": 3894.19, "word": " normally", "probability": 0.884765625}, {"start": 3894.19, "end": 3894.73, "word": " will", "probability": 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The illegal end must result from performance of the contract itself. 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diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/l0j3jkqdeLk_postprocess.srt b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/l0j3jkqdeLk_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..97573d5f5aefd46bea65aee4f8cb73ba518c2903
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/l0j3jkqdeLk_postprocess.srt
@@ -0,0 +1,3580 @@
+1
+00:00:13,340 --> 00:00:18,730
+السلام عليكم، this is the second lecture we haveعن
+
+2
+00:00:18,730 --> 00:00:23,230
+شركات ومجتمعات كما كان للمرة الأخيرة لطلاب الذين
+
+3
+00:00:23,230 --> 00:00:24,930
+كانوا يقومون بالدراسة في المدرسة ، فانت ما زلت
+
+4
+00:00:24,930 --> 00:00:32,790
+تذكر مصطلح التصميم لشركات وقانون الشركات اليوم يجب
+
+5
+00:00:32,790 --> 00:00:37,370
+أن نكمل ما بدأناه المرة الأخيرة يجب أن نكمل هذا
+
+6
+00:00:37,370 --> 00:00:41,010
+النقطة في الواقع يجب أن ننظر إلى نظرية نظرية قانون
+
+7
+00:00:41,010 --> 00:00:50,870
+الشركات سأتحدث عنبناء شركات سأعود لعامين كثير
+
+8
+00:00:50,870 --> 00:00:57,870
+لأستطيع أن أفهم أنت و أنا كيف تم بناء الشركات و
+
+9
+00:00:57,870 --> 00:01:03,670
+لماذا كما تعرف الآن لدينا الكثير من الشركات و كما
+
+10
+00:01:03,670 --> 00:01:07,830
+نستطيع أن نرى في نهاية هذا الحلقه سيكون لدينا أكثر
+
+11
+00:01:07,830 --> 00:01:12,320
+من 10 شركات قانونيةتين مجموعات من المجموعات
+
+12
+00:01:12,320 --> 00:01:16,720
+الانتجارية لذا من احد البلد لآخر لدينا مجموعات
+
+13
+00:01:16,720 --> 00:01:21,340
+مختلفة واسم وشكل من الشركات الشركات يمكن ان تتضمن
+
+14
+00:01:21,340 --> 00:01:27,040
+مشاركة مجموعات مجموعات مجموعات مجموعات مجموعات
+
+15
+00:01:27,040 --> 00:01:27,200
+مجموعات مجموعات مجموعات مجموعات مجموعات مجموعات
+
+16
+00:01:27,200 --> 00:01:27,560
+مجموعات مجموعات مجموعات مجموعات مجموعات مجموعات
+
+17
+00:01:27,560 --> 00:01:27,820
+مجموعات مجموعات مجموعات مجموعات مجموعات مجموعات
+
+18
+00:01:27,820 --> 00:01:28,340
+مجموعات مجموعات مجموعات مجموعات مجموعات مجموعات
+
+19
+00:01:28,340 --> 00:01:36,540
+مجموعات مجموعات م
+
+20
+00:01:40,750 --> 00:01:45,110
+مع مجموعات هذه الشركات، مجموعات هذه الشركات، هل
+
+21
+00:01:45,110 --> 00:01:49,550
+كان لدينا في الماضي شيء مثل هذا؟ و متى كانت أول
+
+22
+00:01:49,550 --> 00:01:55,170
+مرة أن شخص كان لديه شركة؟ كانت في الوقت المسيحي؟
+
+23
+00:01:55,170 --> 00:01:59,970
+كانت قبل ذلك؟ كانت بعد ذلك؟ أعتقد أن الشركات تم
+
+24
+00:01:59,970 --> 00:02:03,930
+إنشئها قبل وقت طويل و شركة .. إذا كنا نحب أن نفهم
+
+25
+00:02:03,930 --> 00:02:05,330
+اسمها، كلمة company
+
+26
+00:02:08,430 --> 00:02:11,110
+company means more than one person more than one
+
+27
+00:02:11,110 --> 00:02:15,610
+person when we say to somebody that I was in the
+
+28
+00:02:15,610 --> 00:02:22,090
+company of my friend I was with my friend like we
+
+29
+00:02:22,090 --> 00:02:25,990
+have two or more than two people company can mean
+
+30
+00:02:25,990 --> 00:02:31,790
+جماعة صحبة more than one person now despite this
+
+31
+00:02:31,790 --> 00:02:35,860
+factنحن في الولايات المتحدة في بعض الشركات التي
+
+32
+00:02:35,860 --> 00:02:42,040
+يمكن أن تكون مبنية مع واحد شخص فقط ولكن في الواقع
+
+33
+00:02:42,040 --> 00:02:44,980
+في معظم البلدان الشركات يجب أن تكون لديها على
+
+34
+00:02:44,980 --> 00:02:49,990
+الأقلتو مجتمعين تو مجتمعين تو مجتمعين تو مجتمعين
+
+35
+00:02:49,990 --> 00:02:50,770
+تو مجتمعين تو مجتمعين تو مجتمعين تو مجتمعين تو
+
+36
+00:02:50,770 --> 00:02:52,270
+مجتمعين تو مجتمعين تو مجتمعين تو مجتمعين تو
+
+37
+00:02:52,270 --> 00:02:54,850
+مجتمعين تو مجتمعين تو مجتمعين تو مجتمعين تو
+
+38
+00:02:54,850 --> 00:02:56,730
+مجتمعين تو مجتمعين تو مجتمعين تو مجتمعين تو
+
+39
+00:02:56,730 --> 00:03:00,130
+مجتمعين تو مجتمعين تو مجتمعين تو مجتمعين تو
+
+40
+00:03:00,130 --> 00:03:08,430
+مجتمعين تو مجتمعين تو مجتمعين تو مجتمعين
+
+41
+00:03:17,540 --> 00:03:20,660
+how can we define a corporation as we had it last
+
+42
+00:03:20,660 --> 00:03:30,220
+time it's not difficult late
+
+43
+00:03:30,220 --> 00:03:33,720
+students you're not gonna have mark today وين ال
+
+44
+00:03:33,720 --> 00:03:35,760
+تماني اللي كانوا the first eight students raise
+
+45
+00:03:35,760 --> 00:03:41,140
+your hand up first eight students okay late why
+
+46
+00:03:41,140 --> 00:03:45,700
+you are late having
+
+47
+00:03:45,700 --> 00:03:51,720
+coffeeWell, don't do it again, you have to be on
+
+48
+00:03:51,720 --> 00:03:56,000
+time, on time Now, how can we define company? Or
+
+49
+00:03:56,000 --> 00:03:58,200
+how can we define a corporation? Last time we had
+
+50
+00:03:58,200 --> 00:04:02,660
+a lecture about the definitions, meaning, concept
+
+51
+00:04:02,660 --> 00:04:07,840
+of corporation What does it mean, Hanin? Legal
+
+52
+00:04:07,840 --> 00:04:15,040
+entity, simple, company is a legal entity, yes?or
+
+53
+00:04:15,040 --> 00:04:17,780
+trusted person who have legal personalities
+
+54
+00:04:21,620 --> 00:04:25,620
+حسنًا، هذه الشركة أو هذه الشركة هي شركة حقوقية
+
+55
+00:04:25,620 --> 00:04:30,100
+التي تحتوي على شركات مختلفة من شركاتها التي تحتوي
+
+56
+00:04:30,100 --> 00:04:31,760
+على شركاتها التي تحتوي على شركاتها التي تحتوي على
+
+57
+00:04:31,760 --> 00:04:33,520
+شركاتها التي تحتوي على شركاتها التي تحتوي على
+
+58
+00:04:33,520 --> 00:04:34,640
+شركاتها التي تحتوي على شركاتها التي تحتوي على
+
+59
+00:04:34,640 --> 00:04:35,960
+شركاتها التي تحتوي على شركاتها التي تحتوي على
+
+60
+00:04:35,960 --> 00:04:36,120
+شركاتها التي تحتوي على شركاتها التي تحتوي على
+
+61
+00:04:36,120 --> 00:04:36,640
+شركاتها التي تحتوي على شركاتها التي تحتوي على
+
+62
+00:04:36,640 --> 00:04:40,260
+شركاتها التي تحتوي على شركاتها التي تحتوي على
+
+63
+00:04:40,260 --> 00:04:51,020
+شركاتها التي تحتوي على شركاتها التي تحتويبالإضافة
+
+64
+00:04:51,020 --> 00:04:55,300
+إلى هذه الدفينيشن، نستطيع أن ندفع مجتمع كهذا هنا
+
+65
+00:04:55,300 --> 00:05:02,140
+يمكن أن يكون تسمى كشخص في قدرة политية، مجتمع يمكن
+
+66
+00:05:02,140 --> 00:05:07,760
+أن يكون شخص في قدرة политية خلقه من القواعد، وكان
+
+67
+00:05:07,760 --> 00:05:13,940
+هذا الشخص قد تم إصلاحه طوال وقت طويل لتتحمل، لتبقى
+
+68
+00:05:14,600 --> 00:05:20,360
+to survive to endure perpetual succession تعاقب
+
+69
+00:05:20,360 --> 00:05:24,240
+دائم for a long time companies can stay for a long
+
+70
+00:05:24,240 --> 00:05:27,020
+time for more than two hundred three hundred five
+
+71
+00:05:27,020 --> 00:05:30,540
+hundred years you can live for seventy eight years
+
+72
+00:05:31,320 --> 00:05:34,340
+more or less but companies can stay for hundreds
+
+73
+00:05:34,340 --> 00:05:36,920
+of years we cannot expect we don't have life
+
+74
+00:05:36,920 --> 00:05:40,320
+expectation for corporations if we look back we
+
+75
+00:05:40,320 --> 00:05:43,220
+find that in the past medieval time before that
+
+76
+00:05:43,220 --> 00:05:46,280
+time and after we had many types of companies many
+
+77
+00:05:46,280 --> 00:05:49,240
+types of companies now you can establish a company
+
+78
+00:05:49,240 --> 00:05:53,630
+as a public maybe private companyyou can have
+
+79
+00:05:53,630 --> 00:05:57,810
+profit company or non profit company you can have
+
+80
+00:05:57,810 --> 00:06:02,150
+small size company you can have large size like
+
+81
+00:06:02,150 --> 00:06:04,910
+corporation in the past we had many types of
+
+82
+00:06:04,910 --> 00:06:07,710
+companies in which like they were based on the
+
+83
+00:06:07,710 --> 00:06:12,310
+interest each company was distinguished from other
+
+84
+00:06:12,310 --> 00:06:16,130
+companies by the purpose they were distinguished
+
+85
+00:06:16,130 --> 00:06:21,950
+from each other based on the purposeالأهداف، بعضها
+
+86
+00:06:21,950 --> 00:06:27,130
+تم خلقها لتنمية التجارب والكثير من الشركات التي
+
+87
+00:06:27,130 --> 00:06:30,210
+لدينا في حياتنا، وليس فقط في فلسطين، وحتى في
+
+88
+00:06:30,210 --> 00:06:33,490
+العديد من الأماكن، في كل البلدان، العديد من
+
+89
+00:06:33,490 --> 00:06:37,490
+الشركات مجتمعة لتنمية التجارب، لتنمية المال،
+
+90
+00:06:37,490 --> 00:06:42,220
+لتنمية الأرباح، بعضها مجتمعةeducation, religion,
+
+91
+00:06:42,760 --> 00:06:47,720
+culture, health مثل ال NGOs، كم عدد NGOs لدينا؟
+
+92
+00:06:47,720 --> 00:06:51,980
+مئات منهم، لكن هؤلاء ال NGOs مبنية تحت مصمم
+
+93
+00:06:51,980 --> 00:06:55,140
+الشركة، إذا كنت أردت أن أكون لدي نفسي NGO، نظام
+
+94
+00:06:55,140 --> 00:07:03,960
+غير حكومي، يمكنني أن أبني شركة، وهي شركة
+
+95
+00:07:03,960 --> 00:07:10,160
+غير ربحية، ويمكننا أن نسميها NGOولكن أكتر الشركات
+
+96
+00:07:10,160 --> 00:07:14,220
+اللي لديها كانت تعمل عملية عمل عمل عمل عمل عمل عمل
+
+97
+00:07:14,220 --> 00:07:15,300
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+98
+00:07:15,300 --> 00:07:16,500
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+99
+00:07:16,500 --> 00:07:16,540
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+100
+00:07:16,540 --> 00:07:16,680
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+101
+00:07:16,680 --> 00:07:17,580
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+102
+00:07:17,580 --> 00:07:21,100
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+103
+00:07:21,100 --> 00:07:24,200
+عمل عمل عمل عمل
+
+104
+00:07:24,200 --> 00:07:27,680
+عمل عمل عمل عمل عمل عمل عمل
+
+105
+00:07:37,990 --> 00:07:41,970
+و حتى لو اليوم لدينا الكثير من الشركات و تلك
+
+106
+00:07:41,970 --> 00:07:46,490
+الشركات تتعامل على كل دولة كم شركات لدينا في
+
+107
+00:07:46,490 --> 00:07:49,770
+فلسطين تقريبا 3 او 4 شركات في الولايات المتحدة
+
+108
+00:07:49,770 --> 00:07:53,650
+يمكن أن يكون لدينا اكثر من 10 شركات او اكتر او اقل
+
+109
+00:07:53,650 --> 00:08:00,130
+يتعامل على كل دولة لكن في كل حالة بعض الناس بعض
+
+110
+00:08:00,130 --> 00:08:04,600
+المدرسين بعض المفهومين كانوا يقولونwe have to be
+
+111
+00:08:04,600 --> 00:08:07,740
+careful when we establish a company especially
+
+112
+00:08:07,740 --> 00:08:13,080
+corporation why why should we be careful why
+
+113
+00:08:13,080 --> 00:08:17,000
+should we take the caution هى caution حضر when we
+
+114
+00:08:17,000 --> 00:08:26,440
+establish corporation why is this؟ عجيب دهusually
+
+115
+00:08:26,440 --> 00:08:29,540
+have more liabilities towards government and
+
+116
+00:08:29,540 --> 00:08:34,380
+towards societies more than any other type of
+
+117
+00:08:34,380 --> 00:08:40,660
+companies anyone else? we have to be careful, we
+
+118
+00:08:40,660 --> 00:08:42,780
+have to take caution, we have to inspect
+
+119
+00:08:42,780 --> 00:08:46,660
+corporations, why should we take all these strict
+
+120
+00:08:46,660 --> 00:08:47,080
+measures?
+
+121
+00:08:50,140 --> 00:08:53,040
+because we .. the money that we invest in this
+
+122
+00:08:53,040 --> 00:09:00,360
+corporation it's not our own money it's for
+
+123
+00:09:00,360 --> 00:09:04,540
+stockholders so we must be careful about this
+
+124
+00:09:04,540 --> 00:09:08,660
+money and big businesses that's one point yeah
+
+125
+00:09:08,660 --> 00:09:11,620
+anyone else? anyone would like to read this point
+
+126
+00:09:11,620 --> 00:09:22,110
+for me? anyone? onein their external
+
+127
+00:09:22,110 --> 00:09:24,710
+actions or transactions corporations that enjoy
+
+128
+00:09:24,710 --> 00:09:30,370
+the same latitude مساحة space as private
+
+129
+00:09:30,370 --> 00:09:32,950
+individuals many saw this as a principal advantage
+
+130
+00:09:32,950 --> 00:09:35,970
+in this corporation why we have to be careful
+
+131
+00:09:35,970 --> 00:09:39,930
+because companies have the same latitude if I as a
+
+132
+00:09:39,930 --> 00:09:42,990
+human being can have my own business I can invest
+
+133
+00:09:42,990 --> 00:09:48,720
+a small amount of moneyأو كمية كبيرة من المال كمية
+
+134
+00:09:48,720 --> 00:09:50,720
+كمية كمية كمية كمية كمية كمية كمية كمية كمية كمية
+
+135
+00:09:50,720 --> 00:09:55,520
+كمية كمية كمية كمية كمية كمية كمية كمية كمية
+
+136
+00:09:55,520 --> 00:10:01,900
+كمية كمية كمية كمية كمية كمية كمية كمية كمية كمية
+
+137
+00:10:01,900 --> 00:10:11,540
+كمية كمية كمية كمية كمية كمية كمية كمية كمية كمية
+
+138
+00:10:11,540 --> 00:10:19,530
+كميةماذا تفعل تفكير هذا المال كبير؟ تفكير بنك مثل
+
+139
+00:10:19,530 --> 00:10:24,070
+HSBC بنك هل تعرفينه؟ واحد من أكبر بنك في العالم
+
+140
+00:10:24,070 --> 00:10:28,870
+HSBC يجعل نسبة المال عامة أكتر من 10 مليون دولار
+
+141
+00:10:28,870 --> 00:10:37,450
+تقريبا 15 مليون دولار وهذا يقل إلى خمس مرات من عقد
+
+142
+00:10:37,450 --> 00:10:45,720
+الحكومة البلسطينية واحد بنك يجعل نسبةوهو اكثر من
+
+143
+00:10:45,720 --> 00:10:49,800
+خمس مرات من عمليات الحكومة البلستينية، لذا فإن
+
+144
+00:10:49,800 --> 00:10:55,900
+تجارب مثل هذه ستكون مفاجئة ليست فقط في مجتمع مجتمع
+
+145
+00:10:55,900 --> 00:11:03,480
+مجتمع مجتمع مجتمع مجتمع مجتمعهو يعمل على مستوى
+
+146
+00:11:03,480 --> 00:11:07,320
+أمريكي، هذا الحكومة يمكنها أن تعمل في العديد من
+
+147
+00:11:07,320 --> 00:11:11,000
+البلدان، في 50 أو 60 البلدان في العالم تخيل مؤسسة
+
+148
+00:11:11,000 --> 00:11:13,320
+مثل هذه، مؤسسة مثل هذه، مؤسسة مثل هذه، مؤسسة مثل
+
+149
+00:11:13,320 --> 00:11:15,160
+هذه، مؤسسة مثل هذه، مؤسسة مثل هذه، مؤسسة مثل هذه،
+
+150
+00:11:15,160 --> 00:11:25,260
+مؤسسة مثل هذه، مؤسسة مثل هذه، مؤسسة
+
+151
+00:11:25,260 --> 00:11:27,980
+مثل هذه، مؤسسة مثل هذه، مؤسسة مثل هذه، مؤسسة مثل
+
+152
+00:11:27,980 --> 00:11:28,280
+هذه، مؤسسة مثل هذه، مؤسسة مثل هذه، مؤسسة مثل هذه،
+
+153
+00:11:28,280 --> 00:11:29,600
+مؤسسة مثل هذه، مؤسسة مثل هذه، مؤسسة مثل هذه، م
+
+154
+00:11:34,810 --> 00:11:37,430
+سيكون هناك مصادرة مثلًا لدينا بعض الشركات في
+
+155
+00:11:37,430 --> 00:11:43,130
+الولايات المتحدة من الانفجار في عام 2008 الموظفين
+
+156
+00:11:43,130 --> 00:11:48,070
+كانوا يبحثون عن .. يبحثون عن ماذا؟ بنيفع من
+
+157
+00:11:48,070 --> 00:11:51,050
+الحكومة، لذلك الحكومة كانت تحتاجة تأخذ مسؤوليتها،
+
+158
+00:11:51,050 --> 00:11:54,490
+اذا كنت الحكومة، كنت سأحتاج أن أطعم هؤلاء الناس،
+
+159
+00:11:54,490 --> 00:11:58,550
+كنت سأحتاج أن أعطيهم المقابلة، كنت سأحتاج أن
+
+160
+00:11:58,550 --> 00:12:03,950
+أدعمهم بطريقة اجتماعيةالنا هؤلاء الناس هؤلاء
+
+161
+00:12:03,950 --> 00:12:09,810
+الموظفين سيكونون كغرض على الحكومة حمولة عبق that's
+
+162
+00:12:09,810 --> 00:12:12,670
+one point the second point is now some companies
+
+163
+00:12:12,670 --> 00:12:17,170
+with such a huge amount of money they would have
+
+164
+00:12:17,170 --> 00:12:20,710
+an impact on the whole society some of them can
+
+165
+00:12:20,710 --> 00:12:24,610
+lead in politics if you have the amount of money
+
+166
+00:12:24,610 --> 00:12:29,130
+you can do anything you like you can buy you can
+
+167
+00:12:29,130 --> 00:12:33,030
+buy a country you can build an armyyou can build
+
+168
+00:12:33,030 --> 00:12:36,750
+if you have fifty thousand employees, that number
+
+169
+00:12:36,750 --> 00:12:40,430
+itself is a number of an army, then you can invest
+
+170
+00:12:40,430 --> 00:12:43,210
+on those people, maybe some companies have even
+
+171
+00:12:43,210 --> 00:12:45,330
+more than this, so those companies we have to be
+
+172
+00:12:45,330 --> 00:12:48,090
+careful with them, those corporations, we do have
+
+173
+00:12:48,090 --> 00:12:50,110
+to be careful, we have to take the caution, we
+
+174
+00:12:50,110 --> 00:12:56,160
+have to inspectانظروا إلى مؤسساتهم ومديراتهم وكيف
+
+175
+00:12:56,160 --> 00:12:59,360
+يعملوا وكيف يعملوا المديرات وكيف يعملوا المديرات
+
+176
+00:12:59,360 --> 00:12:59,680
+وكيف يعملوا المديرات وكيف يعملوا المديرات وكيف
+
+177
+00:12:59,680 --> 00:13:00,920
+يعملوا المديرات وكيف يعملوا المديرات وكيف يعملوا
+
+178
+00:13:00,920 --> 00:13:01,020
+المديرات وكيف يعملوا المديرات وكيف يعملوا المديرات
+
+179
+00:13:01,020 --> 00:13:01,480
+وكيف يعملوا المديرات وكيف يعملوا المديرات وكيف
+
+180
+00:13:01,480 --> 00:13:01,820
+يعملوا المديرات وكيف يعملوا المديرات وكيف يعملوا
+
+181
+00:13:01,820 --> 00:13:01,840
+المديرات وكيف يعملوا المديرات وكيف يعملوا المديرات
+
+182
+00:13:01,840 --> 00:13:10,940
+وكيف يعملوا المديرات وكيف
+
+183
+00:13:10,940 --> 00:13:14,990
+يعملوا المديرات وكبعض الانتصارات لا يملكوا المال
+
+184
+00:13:14,990 --> 00:13:19,330
+ليرحلوا في الانتصار ليرحلوا بأنفسهم لتحصلوا على
+
+185
+00:13:19,330 --> 00:13:21,330
+المال من الانتصارات الانتصارات الانتصارات
+
+186
+00:13:21,330 --> 00:13:23,030
+الانتصارات الانتصارات الانتصارات الانتصارات
+
+187
+00:13:23,030 --> 00:13:25,090
+الانتصارات الانتصارات الانتصارات الانتصارات
+
+188
+00:13:25,090 --> 00:13:25,330
+الانتصارات الانتصارات الانتصارات الانتصارات
+
+189
+00:13:25,330 --> 00:13:25,530
+الانتصارات الانتصارات الانتصارات الانتصارات
+
+190
+00:13:25,530 --> 00:13:25,550
+الانتصارات الانتصارات الانتصارات الانتصارات
+
+191
+00:13:25,550 --> 00:13:27,770
+الانتصارات الانتصارات الانتصارات الانتصارات
+
+192
+00:13:27,770 --> 00:13:34,990
+الانتصارات الانتصارات
+
+193
+00:13:34,990 --> 00:13:36,350
+الانتصار
+
+194
+00:13:40,260 --> 00:13:42,820
+in a company you have something called by law I
+
+195
+00:13:42,820 --> 00:13:46,160
+think I did explain it last time by law what what
+
+196
+00:13:46,160 --> 00:13:53,480
+does it mean by law internal system each institute
+
+197
+00:13:53,480 --> 00:13:56,520
+or company would have its own internal system
+
+198
+00:13:56,520 --> 00:13:59,660
+which is called by law you might have a question
+
+199
+00:13:59,660 --> 00:14:01,760
+in the exam expect it what's the difference
+
+200
+00:14:01,760 --> 00:14:05,920
+between by law and law anyone can answer
+
+201
+00:14:11,780 --> 00:14:16,220
+قول by law and law how can we differentiate
+
+202
+00:14:16,220 --> 00:14:21,240
+between them by law like you said internal
+
+203
+00:14:21,240 --> 00:14:27,640
+traditions and customs used by the organization
+
+204
+00:14:27,640 --> 00:14:31,280
+internally or laws are like laws and laws used by
+
+205
+00:14:31,280 --> 00:14:34,840
+the government or state that are public yes public
+
+206
+00:14:34,840 --> 00:14:38,320
+it's made by the state for the whole society so
+
+207
+00:14:38,320 --> 00:14:41,590
+everyone has to beأو كل واحد يجب أن يتعامل مع
+
+208
+00:14:41,590 --> 00:14:45,330
+القانون يجب أن نقوم بنفسنا ولكن عندما يتعلق
+
+209
+00:14:45,330 --> 00:14:49,390
+بالقانون القانون القانون هو نظام الداخل فهو فقط
+
+210
+00:14:49,390 --> 00:14:55,510
+داخل هذه الشركة وداخل الشركة وداخل الشركات الناس
+
+211
+00:14:55,510 --> 00:15:02,790
+في الخارج من هذه الشركة لن يتعامل مع هذا القانون
+
+212
+00:15:02,790 --> 00:15:06,590
+القانون القانون داخل الشركة نفسها
+
+213
+00:15:09,640 --> 00:15:17,780
+الشركة ستكون لديها قانونها و البلد ستكون لديها
+
+214
+00:15:17,780 --> 00:15:23,940
+قانونها هذا القانون يجب أن يكون متناقض مع القانون
+
+215
+00:15:23,940 --> 00:15:28,140
+في مقارنة متناقض متناقض مع القانون يجب أن يكون
+
+216
+00:15:28,140 --> 00:15:33,660
+متناقض مع القانون و كيف نستخدم هذا القانون في
+
+217
+00:15:33,660 --> 00:15:38,830
+البداية عندما نخلق عندما نجعل الشركةwe have to
+
+218
+00:15:38,830 --> 00:15:44,250
+have its own by law this can be a next cooperation
+
+219
+00:15:44,250 --> 00:15:49,750
+by the act act of establishment هو عقد التأسيس at
+
+220
+00:15:49,750 --> 00:15:52,550
+the time when we establish a company we have
+
+221
+00:15:52,550 --> 00:15:55,470
+something called the act of establishment this act
+
+222
+00:15:55,470 --> 00:15:59,010
+of establishment some documents would include that
+
+223
+00:15:59,010 --> 00:16:02,570
+have to include by law تاستلة what is تاستلة
+
+224
+00:16:04,360 --> 00:16:08,680
+implicitly ضمنى tacitly ضمنى implicitly you have
+
+225
+00:16:08,680 --> 00:16:11,140
+to be annexed to the corporations by the act of
+
+226
+00:16:11,140 --> 00:16:16,100
+their establishment fine now each company would
+
+227
+00:16:16,100 --> 00:16:20,180
+have some duties to do each company what kind of
+
+228
+00:16:20,180 --> 00:16:26,360
+duties every company would have general
+
+229
+00:16:26,360 --> 00:16:30,360
+what does it do the company activities
+
+230
+00:16:32,270 --> 00:16:35,590
+what kind of activities? selling, buying, hiring?
+
+231
+00:16:38,790 --> 00:16:42,110
+legal activities made by the company you say
+
+232
+00:16:42,110 --> 00:16:45,830
+duties many questions are asked I have many
+
+233
+00:16:45,830 --> 00:16:48,630
+questions about the company can you read it honey?
+
+234
+00:16:51,730 --> 00:16:55,610
+what are
+
+235
+00:16:55,610 --> 00:16:57,830
+the duties? you might have a question like this
+
+236
+00:16:57,830 --> 00:16:59,990
+how can you answer it?
+
+237
+00:17:03,450 --> 00:17:06,590
+الوحيد اللي يجب أن تفعله الشركة هي أن تفعل
+
+238
+00:17:06,590 --> 00:17:14,090
+البرنامج اللي كانت مصادرة منه جيد، موضوع اضافي؟
+
+239
+00:17:14,090 --> 00:17:21,190
+انه يدمر المجتمع والطبيعة، نعم، كل شركة قد تكون
+
+240
+00:17:21,190 --> 00:17:26,570
+مجموعة من الطبيعة، عمليات عامة من الطبيعة، سننظر
+
+241
+00:17:26,570 --> 00:17:28,330
+إلى الطبيعة، ماذا يعني الطبيعة؟
+
+242
+00:17:32,730 --> 00:17:36,230
+the nature of the company طبيعة الشركة يعني what
+
+243
+00:17:36,230 --> 00:17:43,010
+does it mean ده not exactly no it's not objectives
+
+244
+00:17:43,010 --> 00:17:48,550
+what the company would want to do the nature طبيعة
+
+245
+00:17:48,550 --> 00:17:50,590
+like for example saying that the islamic
+
+246
+00:17:50,590 --> 00:17:52,930
+university is a company if we imagine it's a
+
+247
+00:17:52,930 --> 00:17:57,270
+company what does it do teaching education isn't
+
+248
+00:17:57,270 --> 00:18:02,190
+itهو التعليم لدينا بعض الشركات مثل bank of
+
+249
+00:18:02,190 --> 00:18:09,450
+Palestine ماذا يفعل؟ جوال جوال شركة ماهي طبيعةها؟
+
+250
+00:18:09,450 --> 00:18:16,070
+خدمة التcommunication وكذا وكذا وكذا وكذا وكذا
+
+251
+00:18:16,070 --> 00:18:17,930
+وكذا وكذا وكذا وكذا وكذا وكذا وكذا وكذا وكذا وكذا
+
+252
+00:18:17,930 --> 00:18:18,230
+وكذا وكذا وكذا وكذا وكذا وكذا وكذا وكذا وكذا وكذا
+
+253
+00:18:18,230 --> 00:18:19,830
+وكذا وكذا وكذا وكذا وكذا وكذا وكذا وكذا وكذا وكذا
+
+254
+00:18:19,830 --> 00:18:20,030
+وكذا وكذا وكذا وكذا وكذا وكذا وكذا وكذا وكذا وكذا
+
+255
+00:18:20,030 --> 00:18:25,610
+وكذا وكذا وكذا ونحن نصنعها من البداية مثلا عندما
+
+256
+00:18:25,610 --> 00:18:30,570
+تكون لديك فعل هذا دعنا نتخيل أن هذا هو الفعلof
+
+257
+00:18:30,570 --> 00:18:33,570
+establishment عقد التأسيس the act of establishment
+
+258
+00:18:33,570 --> 00:18:38,250
+would identify exactly the nature saying what this
+
+259
+00:18:38,250 --> 00:18:40,630
+company would do some people have it just for
+
+260
+00:18:40,630 --> 00:18:44,470
+public trade just to mean trade and business for
+
+261
+00:18:44,470 --> 00:18:47,590
+everything most likely that you have to identify
+
+262
+00:18:47,590 --> 00:18:51,110
+exactly to specify the nature this company for
+
+263
+00:18:51,110 --> 00:18:55,310
+food finance service okay what type of service
+
+264
+00:18:55,310 --> 00:18:58,270
+would it be education research consultation
+
+265
+00:18:58,270 --> 00:19:04,630
+medicineيجب أن نصنع هذه الطبيعة منذ البداية، فإن
+
+266
+00:19:04,630 --> 00:19:10,210
+مؤسستها يجب أن تعمل بطريقة
+
+267
+00:19:10,210 --> 00:19:16,170
+مناسبة لطبيعتها، كل شركة يجب أن تفعل عمليات في
+
+268
+00:19:16,170 --> 00:19:20,070
+طبيعتها نفسها، بالضبط، كما أنني لا أستطيع أن أرى
+
+269
+00:19:20,070 --> 00:19:24,390
+أن البنك البلستاني يمكن أن يتغير إلى التواصل،
+
+270
+00:19:24,390 --> 00:19:24,990
+التواصل التواصل التواصل التواصل التواصل التواصل
+
+271
+00:19:24,990 --> 00:19:25,250
+التواصل التواصل التواصل التواصل التواصل التواصل
+
+272
+00:19:30,080 --> 00:19:34,900
+أنا لا أستطيع أن أتخيل أن شركة تصنيف الإلكترونيكس
+
+273
+00:19:34,900 --> 00:19:40,240
+تستطيع أن تعمل تلكوميكيشن على سبيل المثال، إذا كنت
+
+274
+00:19:40,240 --> 00:19:46,340
+ترغب في تغيير عملياتك، عليك تغيير الطبيعة، عليك
+
+275
+00:19:46,340 --> 00:19:49,260
+تتصنيف شركة كذلك، عليك تتصنيف شركة كذلك، عليك
+
+276
+00:19:49,260 --> 00:19:50,240
+تتصنيف شركة كذلك، عليك تتصنيف شركة كذا، عليك
+
+277
+00:19:50,240 --> 00:19:51,240
+تتصنيف شركة كذا، عليك تتصنيف شركة كذا، عليك تتصنيف
+
+278
+00:19:51,240 --> 00:19:56,340
+شركة كذا، عليك تتصنيف شركة كذا، عليك تتصنيف شركة
+
+279
+00:19:56,340 --> 00:20:00,540
+كذا، عليك تتصنيف شركة كذا، عليك تتصنيف شركةa new
+
+280
+00:20:00,540 --> 00:20:03,720
+nature to have some new duties because if the
+
+281
+00:20:03,720 --> 00:20:06,500
+business was not successful then we can switch
+
+282
+00:20:06,500 --> 00:20:09,720
+which is fine it's up to you but to switch from
+
+283
+00:20:09,720 --> 00:20:12,680
+one type to another to switch from one nature to
+
+284
+00:20:12,680 --> 00:20:15,460
+the second then you have to look at the design
+
+285
+00:20:15,460 --> 00:20:19,580
+which was stated in the act of establishment يعني
+
+286
+00:20:19,580 --> 00:20:23,500
+تصميم عقدة التأسيس look at it and then you can go
+
+287
+00:20:23,500 --> 00:20:27,160
+to something called company house company
+
+288
+00:20:31,160 --> 00:20:36,220
+هي بالعربي مسجد الشركات company house in the UK
+
+289
+00:20:36,220 --> 00:20:40,120
+they call it company house هو مكتب مسجد الشركات
+
+290
+00:20:40,120 --> 00:20:46,760
+then you can switch from one type to the second in
+
+291
+00:20:46,760 --> 00:20:51,780
+addition to this we have the inspection inspection
+
+292
+00:20:51,780 --> 00:20:55,820
+how can we inspect any company how can I make sure
+
+293
+00:20:55,820 --> 00:21:00,100
+this company is abiding by the law or notHow can I
+
+294
+00:21:00,100 --> 00:21:03,240
+make sure if this company is running well and does
+
+295
+00:21:03,240 --> 00:21:05,720
+not cheat, does not deceive people, does not
+
+296
+00:21:05,720 --> 00:21:10,080
+change the law؟ How can I know this؟ حنين؟ Anyone
+
+297
+00:21:10,080 --> 00:21:13,160
+of you has a company? Family, I mean family
+
+298
+00:21:13,160 --> 00:21:17,920
+business. Yeah? Anyone? No one has family
+
+299
+00:21:17,920 --> 00:21:21,620
+business? Companies of some? Yeah? What do you
+
+300
+00:21:21,620 --> 00:21:21,780
+have?
+
+301
+00:21:29,710 --> 00:21:34,970
+إيش بيشتغلوا هنا؟ What does it do؟ Accessories
+
+302
+00:21:34,970 --> 00:21:38,670
+يعني .. Accessories يعني .. and clothes
+
+303
+00:21:44,930 --> 00:21:47,490
+Okay it's a different nature it's not the same at
+
+304
+00:21:47,490 --> 00:21:51,390
+all contractor building construction and the
+
+305
+00:21:51,390 --> 00:21:54,110
+second one is clothes and accessories completely
+
+306
+00:21:54,110 --> 00:22:00,070
+different nature and different duties olive oil
+
+307
+00:22:00,070 --> 00:22:04,590
+this is a third type this one two three sectors
+
+308
+00:22:04,590 --> 00:22:09,140
+each sector will have its ownالطبيعة و مهمتها و
+
+309
+00:22:09,140 --> 00:22:14,180
+ليسوا نفسها في كل شركة يجب أن تكون تحقق ثم لدينا
+
+310
+00:22:14,180 --> 00:22:21,200
+عملية التحقق هذا عملية تفعلها بشخص محدد ثم نسمي
+
+311
+00:22:21,200 --> 00:22:30,060
+هذا الشخص شركة تحقق شركة تحقق
+
+312
+00:22:32,070 --> 00:22:35,310
+في كل دولة ستكون لديها مكتب وهذا يسمى كمبيوتر
+
+313
+00:22:35,310 --> 00:22:39,930
+الشركة هذا الشخص سيكون لديه بعض المساعدات سيساعده
+
+314
+00:22:39,930 --> 00:22:46,270
+في تحكي الشركات ويبحث عنهم و يمكن أن يأتي في أي
+
+315
+00:22:46,270 --> 00:22:52,200
+لحظة في أي وقت فجأة افتح الباب و افتحمقالات
+
+316
+00:22:52,200 --> 00:22:54,700
+ومقالات ومقالات ومقالات ومقالات ومقالات ومقالات
+
+317
+00:22:54,700 --> 00:22:54,840
+ومقالات ومقالات ومقالات ومقالات ومقالات ومقالات
+
+318
+00:22:54,840 --> 00:22:57,500
+ومقالات ومقالات ومقالات ومقالات ومقالات ومقالات
+
+319
+00:22:57,500 --> 00:22:57,840
+ومقالات ومقالات ومقالات ومقالات ومقالات ومقالات
+
+320
+00:22:57,840 --> 00:22:58,600
+ومقالات ومقالات ومقالات ومقالات ومقالات ومقالات
+
+321
+00:22:58,600 --> 00:23:03,360
+ومقالات ومقالات ومقالات ومقالات ومقالات ومقالات
+
+322
+00:23:03,360 --> 00:23:09,120
+ومقالات ومقالات ومقالات ومقالات ومقالات ومقالات
+
+323
+00:23:09,120 --> 00:23:12,340
+ومقالات ومقالات
+
+324
+00:23:16,130 --> 00:23:22,550
+في الماضي كان هذا البرنامج موجود في قوات ملكية
+
+325
+00:23:22,550 --> 00:23:34,090
+البرنامج البرنامج موجودة في قوات
+
+326
+00:23:34,090 --> 00:23:34,970
+ملكية البرنامج موجودة في قوات ملكية البرنامج
+
+327
+00:23:34,970 --> 00:23:35,750
+موجودة في قوات ملكية البرنامج موجودة في قوات ملكية
+
+328
+00:23:35,750 --> 00:23:38,410
+البرنامج موجودة في قوات ملكية البرنامج موجودة في
+
+329
+00:23:38,410 --> 00:23:38,570
+قوات ملكية البرنامج موجودة في قوات ملكية البرنامج
+
+330
+00:23:38,570 --> 00:23:39,030
+البرنامج موجودة في قوات ملكية البرنامج موجودة في
+
+331
+00:23:39,030 --> 00:23:39,850
+قوات ملكية البرنامج موجودة في قوات ملكية البرنامج
+
+332
+00:23:39,850 --> 00:23:45,090
+م
+
+333
+00:23:45,850 --> 00:23:49,410
+بسبب أن هناك شيء مهم، نتحدث عن شركات و الشركات هي
+
+334
+00:23:49,410 --> 00:23:54,610
+شخصيات فكتشة، شخصيات قانونية، يمكنهم أن يتفاعلوا،
+
+335
+00:23:54,610 --> 00:23:57,890
+يملكوا المال، يملكوا القوة في البلد، تخيل أننا
+
+336
+00:23:57,890 --> 00:24:05,070
+نغلق كل الشركات، ماذا سيحدث للعالم؟ سنقلق، سنغلق،
+
+337
+00:24:05,070 --> 00:24:10,250
+لذلك شركات مثل هذه هم شخصياتأشخاص ولا لأ؟ Such
+
+338
+00:24:10,250 --> 00:24:12,990
+companies we have to inspect them .. we have to be
+
+339
+00:24:12,990 --> 00:24:18,150
+strict .. we gonna later on you will seeالشركات
+
+340
+00:24:18,150 --> 00:24:22,230
+الصغيرة لن تكون لديها نفس الانتجار مثل الشركات
+
+341
+00:24:22,230 --> 00:24:26,870
+الكبار إذا انتقلت 50 ألف دولار في شركة واحدة و
+
+342
+00:24:26,870 --> 00:24:32,730
+انتقلت 50 مليون دولار في شركة أخرى فالانتجار سيكون
+
+343
+00:24:32,730 --> 00:24:36,870
+أكثر مقصودًا حتى إن الانتجار للشركة كشركة عامة
+
+344
+00:24:36,870 --> 00:24:41,470
+سيكون أكثر مقصودًا و صعبًا لأن 50 مليون دولار هو
+
+345
+00:24:41,470 --> 00:24:47,160
+شيء كبير و سيؤثر عليك الناس و الحكومةSo you have
+
+346
+00:24:47,160 --> 00:24:51,540
+to be careful with this So again why should we
+
+347
+00:24:51,540 --> 00:24:58,120
+have inspection process؟ I've just explained it
+
+348
+00:24:58,120 --> 00:25:00,680
+Why should we have inspection for the companies?
+
+349
+00:25:04,400 --> 00:25:08,440
+Anyone? Think just about it Do you think that
+
+350
+00:25:08,440 --> 00:25:10,480
+companies are perfect? They're not making
+
+351
+00:25:10,480 --> 00:25:15,540
+mistakes? They are making mistakes Yes? But how
+
+352
+00:25:15,540 --> 00:25:16,260
+can we know this?
+
+353
+00:25:20,590 --> 00:25:22,990
+mainly to protect the economy as a whole and
+
+354
+00:25:22,990 --> 00:25:25,230
+protect the individuals to save their lives؟
+
+355
+00:25:25,230 --> 00:25:27,690
+because we cannot give them the freedom companies
+
+356
+00:25:27,690 --> 00:25:31,650
+have latitude to act as individual and they even
+
+357
+00:25:31,650 --> 00:25:35,210
+can act .. they can act and they can do things
+
+358
+00:25:35,210 --> 00:25:38,250
+more than anyone of you can do they have the money
+
+359
+00:25:38,250 --> 00:25:40,750
+and the power and they have the shareholders and
+
+360
+00:25:40,750 --> 00:25:43,390
+they have the customers they can do lots of things
+
+361
+00:25:43,390 --> 00:25:45,730
+then we have to be careful with those companies we
+
+362
+00:25:45,730 --> 00:25:51,080
+have to stop themوالذين يجب أن يوقفوا المجتمع من
+
+363
+00:25:51,080 --> 00:25:56,420
+أن يستخدموا القوة التي لديهم تذكر أننا قلنا أننا
+
+364
+00:25:56,420 --> 00:26:01,160
+في المعاملات أحيانًا نحن لدينا تأثير غير حقيقي،
+
+365
+00:26:01,160 --> 00:26:04,420
+تأثير غير حقيقي، واحد شخص قوي وواحد شخص ضعيف،
+
+366
+00:26:04,420 --> 00:26:10,960
+الشخص القوي يستخدم تأثير الشخص الضعيف، حسنًا، كيف
+
+367
+00:26:10,960 --> 00:26:16,630
+يمكننا أن نحرر شركة؟dissolve .. حل .. how can we
+
+368
+00:26:16,630 --> 00:26:19,190
+dissolve a company .. how can we end the life of
+
+369
+00:26:19,190 --> 00:26:27,130
+the company .. how can we end it .. today we have
+
+370
+00:26:27,130 --> 00:26:29,830
+a company and we would like to just to dissolve it
+
+371
+00:26:29,830 --> 00:26:33,990
+.. to end it .. how can we do .. أبو محمد .. you
+
+372
+00:26:33,990 --> 00:26:40,630
+want to answer ؟ اعلن ال fless .. بنكروفس ..سهل ..
+
+373
+00:26:40,630 --> 00:26:44,870
+هذا واحد .. هذا واحد طريق .. واحد حلول لهذا ..
+
+374
+00:26:44,870 --> 00:26:49,230
+يمكنك أن تكون مغامرة أو يمكنك أن تعيد القوة للناس
+
+375
+00:26:49,230 --> 00:26:53,930
+اللي هي نفسها .. كما انت شركة هولغو انتقلت في شركة
+
+376
+00:26:53,930 --> 00:26:56,070
+.. يمكنك أن تأخذ المال الخاص بك .. يمكنك أن تنهي
+
+377
+00:26:56,070 --> 00:26:59,050
+كل شيء .. نستطيع من البداية .. نستطيع أن ندفع
+
+378
+00:26:59,050 --> 00:27:03,810
+اتفاقات الحياة .. نستطيع أن نكون في شركة لوقت قصير
+
+379
+00:27:03,810 --> 00:27:09,770
+أو حتى إذا لم نكن لدينا اتفاقات حياة للشركة ..أترن
+
+380
+00:27:09,770 --> 00:27:13,890
+لوقت طويل، نستطيع أن ننهي حياتنا، نستطيع أن نكسرها
+
+381
+00:27:13,890 --> 00:27:19,950
+بـ Surrender، ماهو Surrender؟ يستسلم، Surrender
+
+382
+00:27:19,950 --> 00:27:23,210
+its legal existence to the hands .. into the hands
+
+383
+00:27:23,210 --> 00:27:28,450
+of that power هذا القوة تأتي من .. من أين؟
+
+384
+00:27:28,450 --> 00:27:33,830
+الشركات، قوة الشركات تأتي من الشركات، وكانت مقبولة
+
+385
+00:27:33,830 --> 00:27:39,800
+في البداية، لذا فإن حلول الشركةسيأتي بعد أن الشركة
+
+386
+00:27:39,800 --> 00:27:45,660
+تتسلط نفسها للقوة، نفس القوة، هذه القوة تأتي من
+
+387
+00:27:45,660 --> 00:27:50,640
+القواعد وتأتي من المشاركين، لذلك نستطيع أن نحصل
+
+388
+00:27:50,640 --> 00:27:53,420
+على هذه السلوكية بانكروبسيا ونستطيع أن نحصل على
+
+389
+00:27:53,420 --> 00:28:02,000
+هذه السلوكية بإتقان قوة الشركة إلى نفس المصادر،
+
+390
+00:28:02,000 --> 00:28:07,380
+الناس، المشاركين الذين شركوا في شركتهم، جيد؟ بخير؟
+
+391
+00:28:09,140 --> 00:28:14,340
+I hope so next
+
+392
+00:28:14,340 --> 00:28:18,260
+slide it's about companies law study companies law
+
+393
+00:28:18,260 --> 00:28:24,180
+study you study company law as commercial student
+
+394
+00:28:24,180 --> 00:28:27,460
+studying business administration accounting and
+
+395
+00:28:27,460 --> 00:28:31,960
+you do have to studycompanies law or companies in
+
+396
+00:28:31,960 --> 00:28:36,380
+general this subject is taught for students who
+
+397
+00:28:36,380 --> 00:28:39,500
+studying law and students who studying commerce
+
+398
+00:28:39,500 --> 00:28:43,860
+and business like you now the question so many
+
+399
+00:28:43,860 --> 00:28:46,740
+people can ask what this subject supposed to
+
+400
+00:28:46,740 --> 00:28:50,820
+contain to include how many points we supposed to
+
+401
+00:28:50,820 --> 00:28:54,860
+have in such subject companies law study meaning
+
+402
+00:28:54,860 --> 00:29:00,530
+law schools مدارس القانون offercourses and these
+
+403
+00:29:00,530 --> 00:29:02,910
+courses would cover many aspects like what you
+
+404
+00:29:02,910 --> 00:29:08,110
+studying now these subjects will be summarized
+
+405
+00:29:08,110 --> 00:29:10,810
+under these points the area for study examines
+
+406
+00:29:10,810 --> 00:29:15,390
+issues such as just look at me and imagine company
+
+407
+00:29:15,390 --> 00:29:20,110
+law what can we teach what can we study what's our
+
+408
+00:29:20,110 --> 00:29:21,010
+focus will be on
+
+409
+00:29:25,420 --> 00:29:29,100
+definition like what we have last time how what
+
+410
+00:29:29,100 --> 00:29:33,120
+does it mean a company the entity itself we look
+
+411
+00:29:33,120 --> 00:29:36,100
+at the entity كيان look at the entity here look at
+
+412
+00:29:36,100 --> 00:29:40,960
+that a major form of business entities we look at
+
+413
+00:29:40,960 --> 00:29:44,060
+different types of entities we have many types of
+
+414
+00:29:44,060 --> 00:29:46,540
+companies we have to look at all of them
+
+415
+00:29:46,540 --> 00:29:49,800
+operationally how how these forms of entities
+
+416
+00:29:49,800 --> 00:29:56,800
+formed established or operatedprocess management
+
+417
+00:29:56,800 --> 00:30:03,460
+and dissolve simple isn't it second point you
+
+418
+00:30:03,460 --> 00:30:04,840
+might have something like this in the exam
+
+419
+00:30:04,840 --> 00:30:08,220
+question asking you to talk about the company's
+
+420
+00:30:08,220 --> 00:30:11,500
+law study how can how can we look at this subject
+
+421
+00:30:11,500 --> 00:30:19,820
+second point is liability
+
+422
+00:30:19,820 --> 00:30:23,500
+in all type the main difference between business
+
+423
+00:30:23,500 --> 00:30:26,730
+entities is liabilityيجب أن نستمر في نظر إليه
+
+424
+00:30:26,730 --> 00:30:31,870
+دائمًا الواضحة
+
+425
+00:30:31,870 --> 00:30:34,130
+الواضحة الواضحة الواضحة الواضحة الواضحة الواضحة
+
+426
+00:30:34,130 --> 00:30:34,170
+الواضحة الواضحة الواضحة الواضحة الواضحة الواضحة
+
+427
+00:30:34,170 --> 00:30:35,350
+الواضحة الواضحة الواضحة الواضحة الواضحة الواضحة
+
+428
+00:30:35,350 --> 00:30:38,550
+الواضحة الواضحة الواضحة الواضحة الواضحة الواضحة
+
+429
+00:30:38,550 --> 00:30:40,730
+الواضحة الواضحة الواضحة الواضحة الواضحة الواضحة
+
+430
+00:30:40,730 --> 00:30:44,430
+الواضحة الواضحة الواضحة الواضحة الواضحة الواضحة
+
+431
+00:30:44,430 --> 00:30:53,250
+الواضحة الواضحة الواضحة الواضحة
+
+432
+00:30:54,070 --> 00:30:58,350
+الشركات وليس الشركة نفسها لسنا نتكلم عن قيمة محددة
+
+433
+00:30:58,350 --> 00:31:04,470
+للشركة أو قيمة غير محددة للشركة للمشاركة انها
+
+434
+00:31:04,470 --> 00:31:09,270
+تتعامل مع المشاركين الشركات يمكنك أن تكون لديك
+
+435
+00:31:09,270 --> 00:31:14,450
+قيمة غير محددة إذا كنت مشاركة في شركة مشاركة
+
+436
+00:31:14,450 --> 00:31:19,830
+فيمكنك أن تكون لديك قيمة غير محددة ستكون مسؤول عن
+
+437
+00:31:19,830 --> 00:31:27,600
+كل حدث هذه الشركةالثالث هو
+
+438
+00:31:27,600 --> 00:31:35,800
+الاتصال بين الوظيفة وشركة الشركة لدرجة ما يمكن أن
+
+439
+00:31:35,800 --> 00:31:41,320
+يكون الشركة مسؤولة أو مستحيلة عن أعمال الوظيفة كما
+
+440
+00:31:41,320 --> 00:31:43,800
+كانت في الحلقة الأولى الوظيفة
+
+441
+00:31:47,260 --> 00:31:52,500
+هي لدينا نوع من الاتصال الانتقالي بين شركة ومؤسسة
+
+442
+00:31:52,500 --> 00:31:58,680
+الشركة هنا هي المؤسسة هي المؤسسة ونحن لدينا مؤسسات
+
+443
+00:31:58,680 --> 00:32:05,880
+تكون مؤسسات مستقلين يعملون لشركة ويمكن أن يكونوا
+
+444
+00:32:05,880 --> 00:32:11,000
+مستخدمين عميقين يجب أن نصلح هذا النوع من الاتصال
+
+445
+00:32:11,000 --> 00:32:15,820
+بينهم لكي نستطيع أن نفهم إن كلا الجانبين هنا
+
+446
+00:32:16,930 --> 00:32:25,110
+العاملين يمكن أن يتعامل مع الشركة لأن
+
+447
+00:32:25,110 --> 00:32:29,430
+إذا كانت الشركة تعمل على مجال الشركة فسيكون الشركة
+
+448
+00:32:29,430 --> 00:32:30,850
+المسؤولة عن أعمال الشركة
+
+449
+00:32:34,960 --> 00:32:44,380
+4 افضل و لا افضل من كل مؤسسة لان
+
+450
+00:32:44,380 --> 00:32:49,800
+اليوم اذا كنا نريد ان نبني شركة كيف نختارها؟ ماهو
+
+451
+00:32:49,800 --> 00:32:55,740
+الجمهور اللذي تحب ان تبنيه؟ صغير او كبير؟ افضل او
+
+452
+00:32:55,740 --> 00:32:58,820
+غير افضل؟ انها تعتمد على ما تريد ان تفعله سننظر
+
+453
+00:32:58,820 --> 00:33:04,580
+إلى كل الجمهورأخذها واحدة بعد واحدة لأرى افضال
+
+454
+00:33:04,580 --> 00:33:10,080
+وامساك لأرى أي شركة يستخدمها لسوق شركتي واي شركة
+
+455
+00:33:10,080 --> 00:33:12,520
+يستخدمها لسوق شركتي واي شركة يستخدمها لسوق شركتي
+
+456
+00:33:12,520 --> 00:33:12,800
+واي شركة يستخدمها لسوق شركتي واي شركة يستخدمها
+
+457
+00:33:12,800 --> 00:33:12,820
+لسوق شركتي واي شركة يستخدمها لسوق شركتي واي شركة
+
+458
+00:33:12,820 --> 00:33:14,240
+يستخدمها لسوق شركتي واي شركة يستخدمها لسوق شركتي
+
+459
+00:33:14,240 --> 00:33:14,440
+واي شركة يستخدمها لسوق شركتي واي شركة يستخدمها
+
+460
+00:33:14,440 --> 00:33:24,480
+لسوق شركتي واي شركة يستخدمها لسوق شركتي واي شركة
+
+461
+00:33:24,480 --> 00:33:27,730
+يستخدمها لسوق شركتي واي شركةالنقطة الأخيرة التي
+
+462
+00:33:27,730 --> 00:33:32,270
+ذكرتها في السلسلة الأخيرة كانت الانتجار انتجار كيف
+
+463
+00:33:32,270 --> 00:33:35,150
+يمكننا انتج و كيف يمكننا أن نراقب هو نفس الشيء
+
+464
+00:33:35,150 --> 00:33:41,270
+يعني نفس الشيء هذا هو ميكانيزم هذا هو طريقة التي
+
+465
+00:33:41,270 --> 00:33:48,030
+يجب أن نستخدمها من الحكومة لتعامل مع كل نوع من
+
+466
+00:33:48,030 --> 00:33:53,730
+الشركات في البلد لكي تستطيع تحكم كل شيء في البلد
+
+467
+00:33:53,730 --> 00:33:56,420
+يجب أن يكون هناك ميكانيزم مثل هذاكي تبقى كل
+
+468
+00:33:56,420 --> 00:33:58,080
+الشركات تحت السيطرة
+
+469
+00:34:10,950 --> 00:34:14,250
+الفكرة خلف مؤسسات الشركات هي أنها بإعادة تجميل
+
+470
+00:34:14,250 --> 00:34:18,470
+مفعولات معينة لشركة واحدة، فالعمل يمكن أن يعمل
+
+471
+00:34:18,470 --> 00:34:24,390
+بشكل أفضل ويحصل على نسبة أفضل نسبة نسبة أفضل، جيد،
+
+472
+00:34:24,390 --> 00:34:26,710
+هذا واحد من .. واحد من النقطة التي يجب أن أشرح ..
+
+473
+00:34:26,710 --> 00:34:30,060
+واحد من النقطة التي يجب أن أشرح الفكرة خلفشركات
+
+474
+00:34:30,060 --> 00:34:34,700
+تجمع أشياء مع بعض تجمع .. ماذا تجمع؟ تجمع أشياء مع
+
+475
+00:34:34,700 --> 00:34:38,260
+بعض تجمع أشياء مع بعض أشياء مع بعض أشياء مع بعض
+
+476
+00:34:38,260 --> 00:34:39,120
+أشياء مع بعض أشياء مع بعض أشياء مع بعض أشياء مع
+
+477
+00:34:39,120 --> 00:34:40,980
+بعض أشياء مع بعض أشياء مع بعض أشياء مع بعض أشياء
+
+478
+00:34:40,980 --> 00:34:42,960
+مع بعض أشياء مع بعض أشياء مع بعض أشياء مع بعض
+
+479
+00:34:42,960 --> 00:34:44,980
+أشياء مع بعض أشياء مع بعض أشياء مع بعض أشياء مع
+
+480
+00:34:44,980 --> 00:34:47,140
+بعض أشياء مع بعض أشياء مع بعض أشياء مع بعض أشياء
+
+481
+00:34:47,140 --> 00:34:56,840
+مع بعض أشياء مع بعض أشياء مع بعض أشياء مع
+
+482
+00:34:56,840 --> 00:35:03,400
+بعض أشياء مع بعضwe have functions وظائف these are
+
+483
+00:35:03,400 --> 00:35:07,380
+combined in single entity if we don't have this
+
+484
+00:35:07,380 --> 00:35:10,520
+entity here we will not be able to have such
+
+485
+00:35:10,520 --> 00:35:16,900
+activities and money and profit as individual you
+
+486
+00:35:16,900 --> 00:35:19,340
+have the money you have the mind you might be
+
+487
+00:35:19,340 --> 00:35:23,000
+smart you might have lots of money but you will
+
+488
+00:35:23,000 --> 00:35:26,870
+not be able to act as a group of peopleإذا كان
+
+489
+00:35:26,870 --> 00:35:32,230
+لديك أكتر ناس، أكتر عقل لتفكير، أكتر ناس لتأخذ
+
+490
+00:35:32,230 --> 00:35:36,610
+إدارتهم، و لديك أكتر المال لتستخدمه، و في نهاية
+
+491
+00:35:36,610 --> 00:35:41,270
+اليوم، إذا كانت الـ Payer Boss شركة عملية، شركة
+
+492
+00:35:41,270 --> 00:35:45,910
+نفعية، فهي لتجعلها نفعية، نفعية، و عندما يكون
+
+493
+00:35:45,910 --> 00:35:50,360
+لدينا أكتر ناس، يعني أننا لدينا أكتر نفعيةو أكتر
+
+494
+00:35:50,360 --> 00:35:53,780
+من الناس، و أكتر من العقل لتفكير، لدينا الاختيار،
+
+495
+00:35:53,780 --> 00:35:57,100
+لدينا مديرين من البرنامج، لدينا المال المستخدم،
+
+496
+00:35:57,100 --> 00:36:01,400
+لدينا أشخاص بمنطقة مختلفة و ممتازة، يمكنهم أن
+
+497
+00:36:01,400 --> 00:36:05,300
+يفكروا و يمكنهم أن يضيفوا شيء جديد للشركات، في
+
+498
+00:36:05,300 --> 00:36:09,420
+النقطة الأخيرة في هذا الفيديو، عرض رقم 16، عرض رقم
+
+499
+00:36:09,420 --> 00:36:09,980
+16،
+
+500
+00:36:13,160 --> 00:36:17,120
+الحكومة تقوم بتحفيز التحفيز في عملية تحفيز مفيد
+
+501
+00:36:17,120 --> 00:36:20,160
+بإنشاء
+
+502
+00:36:20,160 --> 00:36:24,360
+قواعد تحمي الأسهم في شركة عملية تحفيز مفيد بإنشاء
+
+503
+00:36:24,360 --> 00:36:24,820
+قواعد تحمي الأسهم في شركة عملية تحفيز مفيد بإنشاء
+
+504
+00:36:24,820 --> 00:36:26,560
+قواعد تحمي الأسهم في شركة عملية تحفيز مفيد بإنشاء
+
+505
+00:36:26,560 --> 00:36:27,760
+قواعد تحفيز مفيد بإنشاء قواعد تحفيز مفيد بإنشاء
+
+506
+00:36:27,760 --> 00:36:31,940
+قواعد تحفيز مفيد بإنشاء قواعد تحفيز مفيد بإنشاء
+
+507
+00:36:31,940 --> 00:36:34,160
+قواعد تحفيز مفيد بإنشاء قواعد تحفيز مفيد بإنشاء
+
+508
+00:36:34,160 --> 00:36:37,860
+قواعد تحفيز
+
+509
+00:36:37,860 --> 00:36:43,480
+مفيد بإنشاء قواعدفي بعض البلدان في العالم لدينا
+
+510
+00:36:43,480 --> 00:36:48,930
+شيء يسمى Socialismوكثير من البلدين اليوم لدينا
+
+511
+00:36:48,930 --> 00:36:55,010
+كبيتاليزم، كبيتاليزم لديك حرصة لتقاتل أو لتقاتل،
+
+512
+00:36:55,010 --> 00:36:58,830
+شركات ومشروع يستطيعون تقاتل مع بعضهم البعض لتجعل
+
+513
+00:36:58,830 --> 00:37:02,750
+المال أكتر والبلدين السوشاليين اللي ليس لدينا بعد
+
+514
+00:37:02,750 --> 00:37:08,270
+اليوم، مثل شينا، شينا كبلد سوشالي، ليس كذلك
+
+515
+00:37:08,270 --> 00:37:11,810
+السوشاليين اللي كانوا في الماضي، لذلك أكتر من
+
+516
+00:37:11,810 --> 00:37:15,590
+الوقت في أكتر البلدين لدينا سيستم كبيتاليزموهو
+
+517
+00:37:15,590 --> 00:37:18,510
+كبيتاليزم، وهو كبيتاليزم اللي يحصل فيه مصطلح،
+
+518
+00:37:18,510 --> 00:37:20,430
+ويحصل فيه الحكومة، ويحصل فيها الحكومة اللي يحصل
+
+519
+00:37:20,430 --> 00:37:21,250
+فيها الحكومة اللي يحصل فيها الحكومة اللي يحصل فيها
+
+520
+00:37:21,250 --> 00:37:21,910
+الحكومة اللي يحصل فيها الحكومة اللي يحصل فيها
+
+521
+00:37:21,910 --> 00:37:23,410
+الحكومة اللي يحصل فيها الحكومة اللي يحصل فيها
+
+522
+00:37:23,410 --> 00:37:25,190
+الحكومة اللي يحصل فيها الحكومة اللي يحصل فيها
+
+523
+00:37:25,190 --> 00:37:25,670
+الحكومة اللي يحصل فيها الحكومة اللي يحصل فيها
+
+524
+00:37:25,670 --> 00:37:27,290
+الحكومة اللي يحصل فيها الحكومة اللي يحصل فيها
+
+525
+00:37:27,290 --> 00:37:35,110
+الحكومة اللي يحصل فيها الحكومة اللي يحصل فيها
+
+526
+00:37:35,110 --> 00:37:40,100
+الحكومة اللي يحطالما أنك تدفع المال طالما أنك
+
+527
+00:37:40,100 --> 00:37:44,260
+تحترم القانون القانون الشركة وانت تتعامل مع
+
+528
+00:37:44,260 --> 00:37:48,320
+القانون القانون على كل شيء كان مصطلح من الحكومة
+
+529
+00:37:48,320 --> 00:37:54,260
+الان الحكومة و الحكومة سوف تساعد فقط لتساعد لتساعد
+
+530
+00:37:54,260 --> 00:38:00,760
+لتساعد الناس في عملية استثمار بخلق قواعد هذه
+
+531
+00:38:00,760 --> 00:38:05,060
+القواعد هذه القواعد هذه القواعد هذه القوة واحدة
+
+532
+00:38:05,060 --> 00:38:09,580
+منهاWhere is that? Company law Company law So
+
+533
+00:38:09,580 --> 00:38:13,980
+company law is made by by the country, by the
+
+534
+00:38:13,980 --> 00:38:17,460
+state, by the government Corporation law is made
+
+535
+00:38:17,460 --> 00:38:21,620
+by by the government or by the state And this law
+
+536
+00:38:21,620 --> 00:38:26,360
+itself would facilitate investment in which people
+
+537
+00:38:26,360 --> 00:38:29,560
+can invest their money to get profit So what's the
+
+538
+00:38:29,560 --> 00:38:31,640
+benefit for the state in this equation?
+
+539
+00:38:34,790 --> 00:38:37,450
+what benefit can the state get؟ what benefit can
+
+540
+00:38:37,450 --> 00:38:42,930
+the government get؟ is it only جيدة؟ just want to
+
+541
+00:38:42,930 --> 00:38:44,890
+listen to you and then .. listen just you have to
+
+542
+00:38:44,890 --> 00:38:48,590
+speak your mind don't be afraid it's easy make a
+
+543
+00:38:48,590 --> 00:38:53,230
+mistake is fine you cannot .. you cannot have the
+
+544
+00:38:53,230 --> 00:38:56,050
+right answer unless you make the mistake try once
+
+545
+00:38:56,050 --> 00:39:01,960
+and twice and many timesit .. it make their
+
+546
+00:39:01,960 --> 00:39:07,780
+countries or cities developed and .. and they
+
+547
+00:39:07,780 --> 00:39:12,060
+serve the .. some service that they can .. the
+
+548
+00:39:12,060 --> 00:39:13,860
+government .. the government cannot serve the
+
+549
+00:39:13,860 --> 00:39:17,140
+people, help the government in serving people and
+
+550
+00:39:17,140 --> 00:39:19,780
+..
+
+551
+00:39:21,310 --> 00:39:25,070
+Usually the company or the state government is
+
+552
+00:39:25,070 --> 00:39:28,670
+usually busy with servicing people and other
+
+553
+00:39:28,670 --> 00:39:34,950
+public stuff, you know, so they need this economy
+
+554
+00:39:34,950 --> 00:39:40,990
+or this burden to .. Yes, the state cannot do
+
+555
+00:39:40,990 --> 00:39:43,990
+everything for the people, the state cannot
+
+556
+00:39:43,990 --> 00:39:48,340
+because the state would not have that powerto do
+
+557
+00:39:48,340 --> 00:39:52,620
+everything to invest money to make business to
+
+558
+00:39:52,620 --> 00:39:58,140
+make a profit and to have the law and security and
+
+559
+00:39:58,140 --> 00:40:00,600
+the legal system in the country and to serve
+
+560
+00:40:00,600 --> 00:40:03,660
+people that's too much for one person to take or
+
+561
+00:40:03,660 --> 00:40:07,100
+for even one organization to takeهذا هو السبب لما
+
+562
+00:40:07,100 --> 00:40:11,100
+الولايات المتحدة هنا تتركها للناس للعملاء للعملاء
+
+563
+00:40:11,100 --> 00:40:15,400
+للعملاء للعملاء للعملاء للعملاء للعملاء للعملاء
+
+564
+00:40:15,400 --> 00:40:16,000
+للعملاء للعملاء للعملاء للعملاء للعملاء للعملاء
+
+565
+00:40:16,000 --> 00:40:16,100
+للعملاء للعملاء للعملاء للعملاء للعملاء للعملاء
+
+566
+00:40:16,100 --> 00:40:16,120
+للعملاء للعملاء للعملاء للعملاء للعملاء للعملاء
+
+567
+00:40:16,120 --> 00:40:17,940
+للعملاء للعملاء للعملاء للعملاء للعملاء للعملاء
+
+568
+00:40:17,940 --> 00:40:18,000
+للعملاء للعملاء للعملاء للعملاء للعملاء للعملاء
+
+569
+00:40:18,000 --> 00:40:22,760
+للعملاء للعملاء للعملاء
+
+570
+00:40:22,760 --> 00:40:26,080
+للعملاء
+
+571
+00:40:26,080 --> 00:40:33,400
+للعملاء للعملاء
+
+572
+00:40:33,910 --> 00:40:37,650
+على المال الذي يتم اختياره كثير من المال الذي يتم
+
+573
+00:40:37,650 --> 00:40:42,750
+اختياره كثير من المال اللي يتم اختياره كثير من
+
+574
+00:40:42,750 --> 00:40:42,790
+المال اللي يتم اختياره كثير من المال اللي يتم
+
+575
+00:40:42,790 --> 00:40:44,370
+اختياره كثير من المال اللي يتم اختياره كثير من
+
+576
+00:40:44,370 --> 00:40:46,110
+المال اللي يتم اختياره كثير من المال اللي يتم
+
+577
+00:40:46,110 --> 00:40:47,810
+اختياره كثير من المال اللي يتم اختياره كثير من
+
+578
+00:40:47,810 --> 00:40:51,130
+المال اللي
+
+579
+00:40:51,130 --> 00:40:55,450
+يتم اختياره كثير من المال اللي يتم اختياره كثير من
+
+580
+00:40:55,450 --> 00:40:58,410
+المال اللي يتم اختياره كثير
+
+581
+00:41:01,150 --> 00:41:05,170
+الشركة لن تتعامل بشكل كبير إلا إذا كانت الشركة تجد
+
+582
+00:41:05,170 --> 00:41:09,850
+خطأ التعامل أو عمل مخاطر يمكن أن تتعامل بشكل كبير
+
+583
+00:41:09,850 --> 00:41:16,190
+يمكن أن تدخل و يتعامل إذا كانت الشركة تتعامل بشكل
+
+584
+00:41:16,190 --> 00:41:16,790
+كبير إذا كانت الشركة تتعامل بشكل كبير إذا كانت
+
+585
+00:41:16,790 --> 00:41:17,610
+الشركة تتعامل بشكل كبير إذا كانت الشركة تتعامل
+
+586
+00:41:17,610 --> 00:41:20,690
+بشكل كبير إذا كانت الشركة تتعامل بشكل كبير إذا
+
+587
+00:41:20,690 --> 00:41:22,450
+كانت الشركة تتعامل بشكل كبير إذا كانت الشركة
+
+588
+00:41:22,450 --> 00:41:24,850
+تتعامل بشكل كبير إذا كانت الشركة تتعامل بشكل كبير
+
+589
+00:41:27,100 --> 00:41:30,100
+take the right decisions against such companies
+
+590
+00:41:30,100 --> 00:41:35,060
+okay how do you find it up to now? so-so? easy?
+
+591
+00:41:38,400 --> 00:41:41,040
+no no don't worry about it I'm gonna talk about it
+
+592
+00:41:41,040 --> 00:41:44,580
+later on again today I will focus on what I'm
+
+593
+00:41:44,580 --> 00:41:47,640
+gonna do with you to help as much as I can to
+
+594
+00:41:47,640 --> 00:41:51,480
+compensate you with the marks you had in the
+
+595
+00:41:51,480 --> 00:41:55,830
+midterm examI mean I want you to understand the
+
+596
+00:41:55,830 --> 00:41:59,370
+subject that's the most important thing if you
+
+597
+00:41:59,370 --> 00:42:01,910
+understand what we have in this book that's our
+
+598
+00:42:01,910 --> 00:42:07,250
+main point then you can think about the exam we
+
+599
+00:42:07,250 --> 00:42:09,010
+have time at the end because we have a
+
+600
+00:42:09,010 --> 00:42:11,070
+presentation and we're going to have to speak
+
+601
+00:42:11,070 --> 00:42:15,690
+about the exam we look at the origins there's
+
+602
+00:42:15,690 --> 00:42:20,130
+something called etymology what's etymology علم
+
+603
+00:42:20,130 --> 00:42:25,230
+الكلام the science of wordsin that cooperation
+
+604
+00:42:25,230 --> 00:42:32,950
+means what؟ what does it come from؟ corpse corpse
+
+605
+00:42:32,950 --> 00:42:40,270
+in English جثة corpus in Latin is a body is I mean
+
+606
+00:42:40,270 --> 00:42:43,810
+in English corpse is a dead body dead body in
+
+607
+00:42:43,810 --> 00:42:47,870
+Latin corpus is a body and this body as we said
+
+608
+00:42:47,870 --> 00:42:52,090
+before cooperation is a body isn't it it's a new
+
+609
+00:42:52,090 --> 00:42:55,130
+bodySo corporation is a new body، company is a new
+
+610
+00:42:55,130 --> 00:42:58,830
+body، a new entity، a new person، a new person وهي
+
+611
+00:42:58,830 --> 00:43:01,870
+group of people authorized to act as an individual
+
+612
+00:43:01,870 --> 00:43:05,610
+Not only like this، even we have similar things،
+
+613
+00:43:05,610 --> 00:43:09,230
+similar Like for example، it's not our subject
+
+614
+00:43:09,230 --> 00:43:11,670
+just as an example to explain it to you
+
+615
+00:43:11,670 --> 00:43:14,850
+University، what does it mean university؟ It's a
+
+616
+00:43:14,850 --> 00:43:19,890
+Latin word In the past university used to mean
+
+617
+00:43:21,060 --> 00:43:25,040
+collection not collection a group of scholars and
+
+618
+00:43:25,040 --> 00:43:29,600
+today become the universitas universitas Latin it
+
+619
+00:43:29,600 --> 00:43:34,780
+means a group of scholars group of scholars and it
+
+620
+00:43:34,780 --> 00:43:38,960
+means today university in UK in England the
+
+621
+00:43:38,960 --> 00:43:42,740
+corporation used to mean council local council
+
+622
+00:43:42,740 --> 00:43:46,450
+بلدي مجلس بلديnot anymore they're not using it in
+
+623
+00:43:46,450 --> 00:43:50,110
+united kingdom now they say the local council we
+
+624
+00:43:50,110 --> 00:43:54,330
+call it in palestine municipality بلدية in the
+
+625
+00:43:54,330 --> 00:43:58,150
+past they used to call it cooperation because it
+
+626
+00:43:58,150 --> 00:44:01,030
+means collection of individuals collection of
+
+627
+00:44:01,030 --> 00:44:07,290
+people united together this
+
+628
+00:44:07,290 --> 00:44:09,870
+is the last subject we have today and i think we
+
+629
+00:44:09,870 --> 00:44:14,230
+have four slides most likelylooking back ..
+
+630
+00:44:14,230 --> 00:44:20,590
+looking back at premodern corporations مقبل الحدثة
+
+631
+00:44:20,590 --> 00:44:25,530
+long time ago I imagine that some students and
+
+632
+00:44:25,530 --> 00:44:28,810
+some people thinking that we did not have
+
+633
+00:44:28,810 --> 00:44:32,390
+companies in the past and we had companies only
+
+634
+00:44:32,390 --> 00:44:35,830
+after medieval time no this is not right we had
+
+635
+00:44:35,830 --> 00:44:41,700
+companies even in ancient India الهند القديمةالروم
+
+636
+00:44:41,700 --> 00:44:46,080
+القديمة، وهي حوال 3000 عامًا، إذا تنظر إلى الروم
+
+637
+00:44:46,080 --> 00:44:49,560
+القديمة، ربما .. أعتقد أنها أكتر من 3000 عامًا،
+
+638
+00:44:49,560 --> 00:44:54,260
+إنها وقت طويل، هل تتخيل الناس في ذلك الوقت لديهم
+
+639
+00:44:54,260 --> 00:45:01,480
+شركات؟ نعم، ماذا تفعل؟ هل هم نفسهم؟ ليسوا نفس
+
+640
+00:45:01,480 --> 00:45:05,040
+الشركات التي لدينا اليوم؟هما ليسوا نفسهم ولكنهم
+
+641
+00:45:05,040 --> 00:45:09,500
+لديهم اشياء مشابهة انهم لديهم بعض الناس متجمعين مع
+
+642
+00:45:09,500 --> 00:45:11,000
+بعضهم مع بعضهم مع بعضهم مع بعضهم مع بعضهم مع بعضهم
+
+643
+00:45:11,000 --> 00:45:11,040
+مع بعضهم مع بعضهم مع بعضهم مع بعضهم مع بعضهم مع
+
+644
+00:45:11,040 --> 00:45:11,140
+بعضهم مع بعضهم مع بعضهم مع بعضهم مع بعضهم مع بعضهم
+
+645
+00:45:11,140 --> 00:45:14,180
+مع بعضهم مع بعضهم مع بعضهم مع بعضهم مع بعضهم مع
+
+646
+00:45:14,180 --> 00:45:16,940
+بعضهم مع بعضهم مع بعضهم مع بعضهم مع بعضهم مع بعضهم
+
+647
+00:45:16,940 --> 00:45:16,960
+بعضهم مع بعضهم مع بعضهم مع بعضهم مع بعضهم مع بعضهم
+
+648
+00:45:16,960 --> 00:45:25,920
+مع بعضهم مع بعضهم مع بعضهم مع بعضهم مع بعضهم مع
+
+649
+00:45:25,920 --> 00:45:33,460
+بعضهم مع بعضهم مع بعضمثلًا ما لدينا اليوم، لقمنا
+
+650
+00:45:33,460 --> 00:45:37,980
+باستخدام المال في الماضي لأجهزة محددة لأجهزة محددة
+
+651
+00:45:37,980 --> 00:45:45,160
+لأجهزة محددة لأجهزة محددة لأجهزة محددة لأجهزة
+
+652
+00:45:45,160 --> 00:45:47,200
+محددة لأجهزة محددة لأجهزة محددة لأجهزة محددة
+
+653
+00:45:47,200 --> 00:45:49,620
+لأجهزة محددة لأجهزة محددة لأجهزة محددة لأجهزة
+
+654
+00:45:49,620 --> 00:46:00,600
+محددة لأجهزة محددة لأجهزة
+
+655
+00:46:00,600 --> 00:46:05,380
+ملا أحد يستطيع إنشاء شركة كانت صعبة جدًا لأي شخص
+
+656
+00:46:05,380 --> 00:46:09,780
+أن يصنعها أنا سأتكلم عن هذا لاحقًا عندما نصل إلى
+
+657
+00:46:09,780 --> 00:46:15,360
+هذا النقطة في الروم القديمة وحتى وحتى بعد وقت
+
+658
+00:46:15,360 --> 00:46:20,220
+المسيحي وحتى 200 عامًا في الولايات المتحدة لا أحد
+
+659
+00:46:20,220 --> 00:46:27,860
+يستطيع إنشاء شركة فقط كانت مصممة ومحررة من سيواط
+
+660
+00:46:29,670 --> 00:46:33,930
+Sanction has two meanings عقوبة sanction it means
+
+661
+00:46:33,930 --> 00:46:38,230
+هي made أنشئت
+
+662
+00:46:38,230 --> 00:46:42,790
+قانونا انشئها قانونا sanctioned by the state while
+
+663
+00:46:42,790 --> 00:46:46,190
+such corporations in other empires were mostly
+
+664
+00:46:46,190 --> 00:46:51,830
+private commercial entities mainly in roman empire
+
+665
+00:46:51,830 --> 00:46:55,690
+corporations were established were sanctioned by
+
+666
+00:46:55,690 --> 00:46:58,970
+the state because it was too expensive too risky
+
+667
+00:46:59,860 --> 00:47:02,680
+الشخص لا يستطيع إنشاء شركات مثلها لأنه يحتاج إلى
+
+668
+00:47:02,680 --> 00:47:07,100
+الكثير من المال ويحتاج أن يأخذ الفرصة ولم يكن
+
+669
+00:47:07,100 --> 00:47:11,980
+المجتمع يستطيع أن يأخذ هذه الفرصة وحتى لو كانت
+
+670
+00:47:11,980 --> 00:47:16,260
+الموضوع مغلقة بطريقة ما في مجتمعات ألمانيا تحافظ
+
+671
+00:47:16,260 --> 00:47:21,100
+على طريقة مثلها لإنشاء شركات مع بعض التواصلات مع
+
+672
+00:47:21,100 --> 00:47:22,320
+بعض التواصلات
+
+673
+00:47:26,560 --> 00:47:34,060
+بعض الناس يقولون ان فكرة المشاركة تعود إلى فكرة
+
+674
+00:47:34,060 --> 00:47:39,300
+الكنيسة وبعض الناس يرتبطون فكرة المشاركة، كيف
+
+675
+00:47:39,300 --> 00:47:44,000
+تصنعها، كيف تجعلها، الشكل، الصمم، الاندوبيدوالز
+
+676
+00:47:44,000 --> 00:47:49,890
+مثل فكرة الكنيسةكانوا يجلسون في المسجد هنا وكانوا
+
+677
+00:47:49,890 --> 00:47:52,790
+يحصلون على شيء يسمى قانون الو قانون الو قانون
+
+678
+00:47:52,790 --> 00:47:56,030
+المكتوب المدور قانون الو قانون المكتوب المدور
+
+679
+00:47:56,030 --> 00:47:58,230
+قانون المكتوب المدور قانون المكتوب المدور قانون
+
+680
+00:47:58,230 --> 00:47:59,690
+المكتوب المدور قانون المكتوب المدور قانون المكتوب
+
+681
+00:47:59,690 --> 00:47:59,790
+المدور قانون المكتوب المدور قانون المكتوب المدور
+
+682
+00:47:59,790 --> 00:48:01,450
+المدور قانون المكتوب المدور قانون المكتوب المدور
+
+683
+00:48:01,450 --> 00:48:16,270
+قانون المكتوب المدور قانون المكتوب المدور قانون
+
+684
+00:48:17,940 --> 00:48:22,180
+كانوا يسيطرون ويعملون كل شيء و كانوا السياسيين
+
+685
+00:48:22,180 --> 00:48:25,500
+يسيطرون من خلال المسجد الآن بعض المدرسين قالوا أن
+
+686
+00:48:25,500 --> 00:48:32,680
+القانون المدور كان مبني عن مفهوم المسجد ماذا يعني
+
+687
+00:48:32,680 --> 00:48:41,580
+هذا؟ كيف يمكنك أن تفهمه؟ لدينا أفكار مختلفة للمسجد
+
+688
+00:48:41,580 --> 00:48:48,770
+لتفسيرهاولكن هم قالوا أن المساعدين أن المسجد
+
+689
+00:48:48,770 --> 00:48:56,590
+كجمهور مفضل من أشخاص مختلفة كشخصية أساسية مثل هذه
+
+690
+00:48:56,590 --> 00:49:02,910
+المسجد كانت أكتر من مجلدها فقط، المسجد لدينا
+
+691
+00:49:02,910 --> 00:49:06,050
+مجلدين، الناس اللي بتصلي، الصلاحيين
+
+692
+00:49:09,240 --> 00:49:14,200
+كان هناك أشخاص في المسجد يستطيعون أن يبقى موجودًا
+
+693
+00:49:14,200 --> 00:49:19,340
+مستمرًا بغض النظر عن موت أي أشخاص مستمرًا بغض
+
+694
+00:49:19,340 --> 00:49:20,400
+أشخاص مستمرًا بغض النظر عن موت أي أشخاص مستمرًا
+
+695
+00:49:20,400 --> 00:49:21,180
+بغض النظر عن موت أي أشخاص مستمرًا بغض النظر عن موت
+
+696
+00:49:21,180 --> 00:49:21,800
+أي أشخاص مستمرًا بغض النظر عن موت أي أشخاص مستمرًا
+
+697
+00:49:21,800 --> 00:49:26,040
+بغض النظر عن موت أي أشخاص مستمرًا بغض النظر عن موت
+
+698
+00:49:26,040 --> 00:49:34,020
+أي أشخاص مستمرًا
+
+699
+00:49:34,020 --> 00:49:39,290
+بغض النظر عن موت أي أشخاص مستمرًا بغالشركة تستطيع
+
+700
+00:49:39,290 --> 00:49:44,630
+أن تكون مستقل من موت بعض الأعضاء، بعض الأعضاء يمكن
+
+701
+00:49:44,630 --> 00:49:47,350
+أن يموتوا، بعضهم يمكن أن يتركنوا، يمكنهم أن يسحبوا
+
+702
+00:49:47,350 --> 00:49:50,870
+الشركات و يستطيعوا أن يتركنوا الشركة لديها أشخاص
+
+703
+00:49:50,870 --> 00:49:55,670
+يعبدون، يستطيعون أن يتركنوا، يستطيعون أن يموتوا،
+
+704
+00:49:55,670 --> 00:49:58,770
+لكن الشركة نفسها يستطيع أن تبقى و الشركة لديها
+
+705
+00:49:58,770 --> 00:50:06,540
+رئيس و الشركة ستكون لديها الشيخwho's the head of
+
+706
+00:50:06,540 --> 00:50:09,460
+the churches and that's .. that's saying a
+
+707
+00:50:09,460 --> 00:50:12,620
+conception in which some individual some scholars
+
+708
+00:50:12,620 --> 00:50:17,020
+were trying to identify the meaning of the
+
+709
+00:50:17,020 --> 00:50:20,460
+corporation and simulate it .. simulate it with
+
+710
+00:50:20,460 --> 00:50:23,800
+the meaning of the church يعني بحاولوا what's a
+
+711
+00:50:23,800 --> 00:50:27,700
+simulation شابه قارن
+
+712
+00:50:28,940 --> 00:50:32,700
+و من هناك، من هذا النقطة، هذه الفكرة تم تطبيقها مع
+
+713
+00:50:32,700 --> 00:50:38,960
+الوقت، تم تطبيقها مع الناقشة، هل أحد يريد أن يقرأ؟
+
+714
+00:50:38,960 --> 00:50:43,920
+عياد؟ هذه الفكرة التي تم تطبيقها مع الناقشة هي
+
+715
+00:50:43,920 --> 00:50:49,380
+علاقة بين رئيس مجلس مجلس مجلس مجلس مجلس مجلس مجلس
+
+716
+00:50:49,380 --> 00:50:54,540
+مجلس مجلس مجلس
+
+717
+00:50:56,520 --> 00:50:59,760
+هذا التطور أتت من هذا النقطة، نقطة التي كانت
+
+718
+00:50:59,760 --> 00:51:04,120
+الكنيسة تقف و تعيش لوقت طويل و تكون لديها أعضاء و
+
+719
+00:51:04,120 --> 00:51:07,880
+ممكن أن تبقى مجتمع مستقل هنا و الانتقال يقسم
+
+720
+00:51:07,880 --> 00:51:16,380
+المجتمع إما كمجتمع صول مجتمع مجتمع مجتمع مثل ..
+
+721
+00:51:16,380 --> 00:51:20,800
+مثل .. بعض من هذه المجتمع مجتمع مجتمع مجتمع مجتمع
+
+722
+00:51:20,800 --> 00:51:27,200
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمعaggregation هو
+
+723
+00:51:27,200 --> 00:51:31,980
+تراكم and some of them can be which is solely one
+
+724
+00:51:31,980 --> 00:51:35,900
+person I think they mean by this is the head more
+
+725
+00:51:35,900 --> 00:51:38,040
+than anything else because if we would like to
+
+726
+00:51:38,040 --> 00:51:42,940
+base this argument in which that theالشركة، الشركة
+
+727
+00:51:42,940 --> 00:51:45,900
+تحتاج إلى واحد شخص، أنا لا أعتقد أن هذا سيكون شيء
+
+728
+00:51:45,900 --> 00:51:50,560
+قادم لأن الشركة ستحتاج إلى العديد من الشخصيات
+
+729
+00:51:50,560 --> 00:51:51,880
+تتجمد وتتجمد وتتجمد وتتجمد وتتجمد وتتجمد وتتجمد
+
+730
+00:51:51,880 --> 00:51:53,820
+وتتجمد وتتجمد وتتجمد وتتجمد وتتجمد وتتجمد وتتجمد
+
+731
+00:51:53,820 --> 00:51:54,060
+وتتجمد وتتجمد وتتجمد وتتجمد وتتجمد وتتجمد وتتجمد
+
+732
+00:51:54,060 --> 00:51:56,700
+وتتجمد وتتجمد وتتجمد وتتجمد وتتجمد وتتجمد وتتجمد
+
+733
+00:51:56,700 --> 00:52:05,040
+وتتجم
+
+734
+00:52:10,310 --> 00:52:15,610
+دعنا نكمل ما لدينا .. دعنا نرى كيف يعمل .. تطور
+
+735
+00:52:15,610 --> 00:52:16,830
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+736
+00:52:16,830 --> 00:52:21,370
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+737
+00:52:21,370 --> 00:52:23,610
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+738
+00:52:23,610 --> 00:52:23,730
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+739
+00:52:23,730 --> 00:52:39,130
+مجتمع مج
+
+740
+00:52:41,400 --> 00:52:46,120
+قبل قليل من الوقت ذكرت أن الشركات لم تكن مبنية من
+
+741
+00:52:46,120 --> 00:52:48,940
+أشخاص مبنية من الشركات كانت مبنية من أشخاص من
+
+742
+00:52:48,940 --> 00:52:54,140
+الشركات من الشركات من الشركات من الشركات من
+
+743
+00:52:54,140 --> 00:52:54,160
+الشركات من الشركات من الشركات من الشركات من
+
+744
+00:52:54,160 --> 00:52:54,380
+الشركات من الشركات من الشركات من الشركات من
+
+745
+00:52:54,380 --> 00:52:57,060
+الشركات من الشركات من الشركات من الشركات من
+
+746
+00:52:57,060 --> 00:52:57,120
+الشركات من الشركات من الشركات من الشركات من
+
+747
+00:52:57,120 --> 00:52:59,440
+الشركات من الشركات من الشركات من الشركات من
+
+748
+00:52:59,440 --> 00:53:07,200
+الشركات من الشركات من الشركات من
+
+749
+00:53:07,200 --> 00:53:10,800
+الشركات
+
+750
+00:53:11,720 --> 00:53:24,400
+كان عميق للشخص أن يقوم ببناء شركة مثل هذه وحتى بعض
+
+751
+00:53:24,400 --> 00:53:27,140
+الاشخاص كانوا يسألون السؤال لماذا لم يتمكن الشخص
+
+752
+00:53:27,140 --> 00:53:31,220
+أن يقوم ببناء شركة على الرغم من أن بعضهم كان لديهم
+
+753
+00:53:31,220 --> 00:53:36,440
+المال لذلك وليس فقط عن المال وليس فقط أنه كان خطر
+
+754
+00:53:36,440 --> 00:53:40,240
+جدا أن تأخذ ..أعني خطر جدا أنه كان خطر جدا لكنه لم
+
+755
+00:53:40,240 --> 00:53:43,670
+يكن خطر جداfor some for some people too risky
+
+756
+00:53:43,670 --> 00:53:47,090
+because if you look at this if you look at this
+
+757
+00:53:47,090 --> 00:53:49,270
+slide here you will see that there were some
+
+758
+00:53:49,270 --> 00:53:52,730
+companies in the past those companies were part of
+
+759
+00:53:52,730 --> 00:53:56,090
+the state were division of the state in which the
+
+760
+00:53:56,090 --> 00:53:59,970
+state was using them for colonial purpose colonial
+
+761
+00:53:59,970 --> 00:54:05,390
+استعمار يعني أهداف استعمرية those corporations
+
+762
+00:54:05,390 --> 00:54:12,350
+like for exampleDutch East India و هدسون بيه و
+
+763
+00:54:12,350 --> 00:54:13,070
+هدسون بيه و هدسون بيه و هدسون بيه و هدسون بيه و
+
+764
+00:54:13,070 --> 00:54:15,190
+هدسون بيه و هدسون بيه و هدسون بيه و هدسون بيه و
+
+765
+00:54:15,190 --> 00:54:16,710
+هدسون بيه و هدسون بيه و هدسون بيه و هدسون بيه و
+
+766
+00:54:16,710 --> 00:54:18,050
+هدسون بيه و هدسون بيه و هدسون بيه و هدسون بيه و
+
+767
+00:54:18,050 --> 00:54:24,670
+هدسون بيه و هدسون بيه و هدسون بيه و هدسون بيه و
+
+768
+00:54:24,670 --> 00:54:34,190
+هدسون بيه و هدسون بيه و
+
+769
+00:54:34,190 --> 00:54:39,110
+هدسدتش إيست إنديا أو كتير منهم ربما انت متعرف على
+
+770
+00:54:39,110 --> 00:54:42,670
+قناة السويسك مثلا نعم ولكنني بحاجة لشخص يتحدث عن
+
+771
+00:54:42,670 --> 00:54:46,050
+واحدة من هذه الشركات في الأسبوع حسنا سأتحدث عن ذلك
+
+772
+00:54:46,050 --> 00:54:52,130
+اليوم حدسون حسنا لذا سنحتاج شخص يتحدث عن دتش إيست
+
+773
+00:54:52,130 --> 00:54:56,850
+إنديا هل تتحدثت قبل ذلك؟ هل قمت بتفاصيلة؟ بصراحة
+
+774
+00:54:56,850 --> 00:55:02,250
+لا في الأسبوع هذا هو
+
+775
+00:55:02,250 --> 00:55:07,520
+السبب لم يتمكن بعض الناس من إنشاءبناء شركات مثلها
+
+776
+00:55:07,520 --> 00:55:10,440
+لأنهم مرتبطين وإذا تتخيل أنك تنظر مرة أخرى إلى
+
+777
+00:55:10,440 --> 00:55:14,500
+شركات مثلها في الماضي ستجد أن بعضهم كانوا يعملون
+
+778
+00:55:14,500 --> 00:55:17,620
+على محافظة الحكومة مثلما كانت الولايات المتحدة في
+
+779
+00:55:17,620 --> 00:55:20,900
+الولايات المتحدة استعملوا الكثير من الشركات لأن
+
+780
+00:55:20,900 --> 00:55:23,720
+الولايات المتحدة كانت مملكة اللي لا تغيب عن الشمس
+
+781
+00:55:23,720 --> 00:55:27,300
+مملكة اللي لا تغيب عن الشمس مملكة اللي لا تغيب عن
+
+782
+00:55:27,300 --> 00:55:28,560
+الشمس مملكة اللي لا تغيب عن الشمس مملكة اللي لا
+
+783
+00:55:28,560 --> 00:55:32,140
+تغيب عن الشمس مملكة اللي لا تغيب عن الشمس مملكة
+
+784
+00:55:32,140 --> 00:55:37,930
+اللي لا تغيب عن الشمس مملكةفي اندرسيا لديها الكثير
+
+785
+00:55:37,930 --> 00:55:41,490
+من الشركات وهذه الشركات تعمل على محافظة الحكومة
+
+786
+00:55:41,490 --> 00:55:44,930
+البريطانية على محافظة الحكومة البريطانية على
+
+787
+00:55:44,930 --> 00:55:50,510
+محافظة الحكومة البريطانية على محافظة الحكومة
+
+788
+00:55:50,510 --> 00:55:51,010
+البريطانية على محافظة الحكومة البريطانية على
+
+789
+00:55:51,010 --> 00:55:51,030
+محافظة الحكومة البريطانية على محافظة الحكومة
+
+790
+00:55:51,030 --> 00:55:51,750
+محافظة الحكومة البريطانية على محافظة الحكومة
+
+791
+00:55:51,750 --> 00:55:53,690
+البريطانية على محافظ
+
+792
+00:56:07,820 --> 00:56:12,000
+It was not only it was not only such corporations
+
+793
+00:56:12,000 --> 00:56:15,060
+were made by the state not only in addition to
+
+794
+00:56:15,060 --> 00:56:20,990
+that each corporation would wantوكانت تتطلب في ذلك
+
+795
+00:56:20,990 --> 00:56:26,070
+الوقت قانون خاص يعني بدها قانون خاص، كل شركة تريد
+
+796
+00:56:26,070 --> 00:56:30,690
+و كانت تحتاج لديها قانون خاص، الان ما لدينا في
+
+797
+00:56:30,690 --> 00:56:35,230
+بلستان، في كل دولة، لدينا فقط واحد قانون، قانون
+
+798
+00:56:35,230 --> 00:56:40,870
+الشركة و هذا القانون الشركة سيحكم في كل شيء، في
+
+799
+00:56:40,870 --> 00:56:43,650
+ذلك الوقت، في الوقت المحدد، في السنة التاسعة، حوال
+
+800
+00:56:43,650 --> 00:56:49,320
+200 سنة قبلخصوصا في الحكومة، كل شركة، ليس شركة
+
+801
+00:56:49,320 --> 00:56:53,280
+بشكل عام، كل شركة تحتاج لتحتاج لتحتاج لتحتاج
+
+802
+00:56:53,280 --> 00:56:53,700
+لتحتاج لتحتاج لتحتاج لتحتاج لتحتاج لتحتاج لتحتاج
+
+803
+00:56:53,700 --> 00:56:56,940
+لتحتاج لتحتاج لتحتاج لتحتاج لتحتاج لتحتاج لتحتاج
+
+804
+00:56:56,940 --> 00:56:57,260
+لتحتاج لتحتاج لتحتاج لتحتاج لتحتاج لتحتاج لتحتاج
+
+805
+00:56:57,260 --> 00:56:59,060
+لتحتاج لتحتاج لتحتاج لتحتاج لتحتاج لتحتاج لتحتاج
+
+806
+00:56:59,060 --> 00:57:00,300
+لتحتاج لتحتاج لتحتاج لتحتاج لتحتاج لتحتاج لتحتاج
+
+807
+00:57:00,300 --> 00:57:04,700
+لتحتاج لتحتاج لتحتاج لتحتاج لتحتاج لتحتاج لتحتاج
+
+808
+00:57:04,700 --> 00:57:08,780
+لتحتاج لتحتاج
+
+809
+00:57:08,780 --> 00:57:09,180
+لت
+
+810
+00:57:12,040 --> 00:57:15,820
+لكن بعد ذلك هنا كما ترى الكثير من الشركات الخاصة
+
+811
+00:57:15,820 --> 00:57:21,160
+في ذلك الوقت لم تقوموا بإنشاء شركات معينة الكثير
+
+812
+00:57:21,160 --> 00:57:24,440
+من الشركات الخاصة قاموا بإنشاء شركات صغيرة فقط
+
+813
+00:57:24,440 --> 00:57:28,680
+لهذه السبب لرسقها لأنها كانت رسقية كانت كثير عارفة
+
+814
+00:57:28,680 --> 00:57:32,960
+وكانت تعمل للهدف الحكومي للهدف القولوني وهذا هو
+
+815
+00:57:32,960 --> 00:57:35,260
+السبب لمعرفة الكثير من الشركات الخاصة في القرن
+
+816
+00:57:35,260 --> 00:57:35,580
+ال19
+
+817
+00:57:42,160 --> 00:57:46,080
+في النهاية، هذه الحالة لم تستمر طوال زمن، هذه
+
+818
+00:57:46,080 --> 00:57:49,060
+الحالة لم تستمر طوال زمن طوال وقت طويل، في
+
+819
+00:57:49,060 --> 00:57:52,560
+النهاية، نجد أن الحكومات، الحكومات الدولية بدأت
+
+820
+00:57:52,560 --> 00:58:00,400
+تدرس بحاجة لإستثمار، بعض الحكومات مثل الولايات
+
+821
+00:58:00,400 --> 00:58:08,180
+المتحدة بدأت تعطي فرصة للناس لإنشاء شركات بعد وقت
+
+822
+00:58:08,180 --> 00:58:12,640
+طويل، كنت أفكر، حسنًا، الحكومة كانت كافيةوقد أعطى
+
+823
+00:58:12,640 --> 00:58:18,320
+الحرية لأي شخص في البلد أن يكون لديه شركة و هذا ما
+
+824
+00:58:18,320 --> 00:58:24,340
+حدث في السنة التاسعة كانت نيجرزيا أول شرطة في
+
+825
+00:58:24,340 --> 00:58:27,220
+الولايات المتحدة لتقديم هذه القوة والشركة الثانية
+
+826
+00:58:27,220 --> 00:58:32,030
+كانت ديليويركانوا يعطوني فرصة لأي شخص يريد أن يكون
+
+827
+00:58:32,030 --> 00:58:34,590
+لديه شركة أو مجتمع أو مجتمع أو مجتمع أو مجتمع أو
+
+828
+00:58:34,590 --> 00:58:35,250
+مجتمع أو مجتمع أو مجتمع أو مجتمع أو مجتمع أو مجتمع
+
+829
+00:58:35,250 --> 00:58:37,830
+أو مجتمع أو مجتمع أو مجتمع أو مجتمع أو مجتمع أو
+
+830
+00:58:37,830 --> 00:58:40,590
+مجتمع أو مجتمع أو مجتمع أو مجتمع أو مجتمع أو مجتمع
+
+831
+00:58:40,590 --> 00:58:40,730
+أو مجتمع أو مجتمع أو مجتمع أو مجتمع أو مجتمع أو
+
+832
+00:58:40,730 --> 00:58:40,770
+مجتمع أو مجتمع أو مجتمع أو مجتمع أو مجتمع أو مجتمع
+
+833
+00:58:40,770 --> 00:58:45,110
+أو مجتمع أو مجتمع أو مجتمع أو مجتمع أو مجتمع أو
+
+834
+00:58:45,110 --> 00:58:54,310
+مجتمع أو مجتمع أو
+
+835
+00:58:56,630 --> 00:59:02,890
+و يوجد بعض المساعدات التي تساعدك في إدارة هذه
+
+836
+00:59:02,890 --> 00:59:08,850
+الشركات و هذا حتى بعد أن مدينة نيوجيرس كانت تتبع
+
+837
+00:59:08,850 --> 00:59:15,190
+ما حدث في الـ Delaware تحاول أن تشجع الناس لديهم
+
+838
+00:59:15,190 --> 00:59:19,050
+أكتر شركة في
+
+839
+00:59:19,050 --> 00:59:25,360
+السنة التاسعة بعد السنة التاسعة أيضاهنا أيضًا،
+
+840
+00:59:25,360 --> 00:59:29,580
+لدينا تحويل للإدارة، خصوصًا بعد الحرب الأولى
+
+841
+00:59:29,580 --> 00:59:37,760
+والثانوية، لدينا أكتر شركات تم إدارتها تحت نفس
+
+842
+00:59:37,760 --> 00:59:44,480
+القانون، لذلك لم تكن الموضوع مستمر أبدًاكانت هناك
+
+843
+00:59:44,480 --> 00:59:48,260
+فرصة كبيرة في الواقع أن الكثير من الشركات و الكثير
+
+844
+00:59:48,260 --> 00:59:51,040
+من الشركات كانت مبنية و كانت هذه الشركات مبنية
+
+845
+00:59:51,040 --> 00:59:55,840
+خاصة في أول عالم .. في أول عالم .. في أول عالم ..
+
+846
+00:59:55,840 --> 00:59:57,160
+في أول عالم .. في أول عالم .. في أول عالم .. في
+
+847
+00:59:57,160 --> 00:59:57,180
+أول عالم .. في أول عالم .. في أول عالم .. في أول
+
+848
+00:59:57,180 --> 00:59:57,340
+عالم .. في أول عالم .. في أول عالم .. في أول عالم
+
+849
+00:59:57,340 --> 00:59:59,380
+.. في أول عالم .. في أول عالم .. في أول عالم .. في
+
+850
+00:59:59,380 --> 00:59:59,940
+أول عالم .. في أول عالم .. في أول عالم .. في أول
+
+851
+00:59:59,940 --> 01:00:00,000
+عالم .. في أول عالم .. في أول عالم .. في أول عالم
+
+852
+01:00:00,000 --> 01:00:01,820
+.. في أول عالم .. في أول عالم .. في أول عالم .. في
+
+853
+01:00:01,820 --> 01:00:07,040
+أول عالم .. في
+
+854
+01:00:07,040 --> 01:00:13,160
+أول عالم .. في أول عالخاصة بها فيما يسمح ببيع
+
+855
+01:00:13,160 --> 01:00:15,740
+خدمات مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات
+
+856
+01:00:15,740 --> 01:00:16,060
+مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات
+
+857
+01:00:16,060 --> 01:00:16,100
+مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات
+
+858
+01:00:16,100 --> 01:00:16,700
+مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات
+
+859
+01:00:16,700 --> 01:00:16,860
+مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات
+
+860
+01:00:16,860 --> 01:00:18,380
+مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات
+
+861
+01:00:18,380 --> 01:00:19,420
+مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات
+
+862
+01:00:19,420 --> 01:00:22,240
+مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات
+
+863
+01:00:22,240 --> 01:00:38,620
+مستخدمات مست
+
+864
+01:00:39,210 --> 01:00:42,850
+conglomerations which is mainly which means large
+
+865
+01:00:42,850 --> 01:00:45,930
+companies or multi industrial multi industrial
+
+866
+01:00:45,930 --> 01:00:51,310
+company some steps were taken at the end which is
+
+867
+01:00:51,310 --> 01:00:54,250
+what was a few years ago some places like japan
+
+868
+01:00:54,250 --> 01:00:57,770
+the states germany and other countries they have
+
+869
+01:00:57,770 --> 01:01:02,500
+something called conglomerationمجموعة من الشركات،
+
+870
+01:01:02,500 --> 01:01:05,900
+اكثر من شركة واحدة، اكثر من شركة واحدة، مجتمعة مع
+
+871
+01:01:05,900 --> 01:01:09,900
+بعض، مثل ما لدينا في الولايات المتحدة وشينا، حوالي
+
+872
+01:01:09,900 --> 01:01:13,420
+6 أو 7 عامًا، لديهم شركة جديدة، واحدة منهم في
+
+873
+01:01:13,420 --> 01:01:16,060
+الولايات المتحدة وواحدة منهم في الشينا، مجتمعة مع
+
+874
+01:01:16,060 --> 01:01:21,340
+بعض، GM في الشينا وRover في الولايات المتحدة
+
+875
+01:01:21,340 --> 01:01:27,180
+ومصادر السيارات، كانت GM Rover، هل سمعت عنها؟
+
+876
+01:01:33,900 --> 01:01:38,080
+وأخيرًا، مع هذه الحالة، وهو نقطة مهمة هنا، مع هذه
+
+877
+01:01:38,080 --> 01:01:42,700
+الحالة، ما نجده اليوم، نحن لدينا كبيتاليزم، الناس
+
+878
+01:01:42,700 --> 01:01:46,680
+يستخدمون الأموال، مقارنة، نحن لدينا بعض الشركات
+
+879
+01:01:46,680 --> 01:01:51,800
+التي لديها ألف مستخدمين، بعض الشركات التي لديها
+
+880
+01:01:51,800 --> 01:01:56,640
+ألف مستخدمين، نحن لدينا مستخدمين صغيرين، التحكم تم
+
+881
+01:01:56,640 --> 01:01:57,200
+تخلصه
+
+882
+01:01:59,920 --> 01:02:04,920
+والمديرين من المجتمعين يعتمدون على قوة تحكم عملنا
+
+883
+01:02:04,920 --> 01:02:10,200
+مثلما يكون لديهم شركات كبيرة مثل جي أمبروفر يمكن
+
+884
+01:02:10,200 --> 01:02:14,020
+أن يكون لديك ألف شركات ولكن كم من الناس يتحكمون
+
+885
+01:02:14,020 --> 01:02:20,200
+فيها؟ ربما 9، 10، 20 اشخاص صغير، هذا ما يسمى مجلس
+
+886
+01:02:20,200 --> 01:02:25,020
+التحكم أو مجلس المديرينهم يستطيعون أن يتحكموا
+
+887
+01:02:25,020 --> 01:02:29,520
+لديهم التحكم والقوة ولكن معظم المؤسسات لا هم فقط
+
+888
+01:02:29,520 --> 01:02:33,740
+يستخدمون المال وهذا أدى لتحريك في الولايات المتحدة
+
+889
+01:02:33,740 --> 01:02:39,000
+في عام 2008 كثير من الناس خسروا مالهم لأن مديرات
+
+890
+01:02:39,000 --> 01:02:43,740
+الوزيرات كانوا يخاطرون ولم يتبعوا القانون وسبب ذلك
+
+891
+01:02:43,740 --> 01:02:47,140
+الانفجار من الكثير من الشركات من الكثير منهم
+
+892
+01:02:47,140 --> 01:02:48,820
+وانتجوا
+
+893
+01:02:50,840 --> 01:02:55,340
+ملايين من الناس، ملايين من الناس، وحتى مؤخراً
+
+894
+01:02:55,340 --> 01:02:59,180
+لدينا اكتشافات أكتشافات أكتشافات اكتشافات اكتشافات
+
+895
+01:02:59,180 --> 01:03:01,900
+اكتشافات اكتشافات اكتشافات اكتشافات
+
diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/nMUc4Kth5Ys_postprocess.srt b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/nMUc4Kth5Ys_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..4d74973c20334dbc4c21c61c571fa175251f6807
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/nMUc4Kth5Ys_postprocess.srt
@@ -0,0 +1,3792 @@
+1
+00:00:11,600 --> 00:00:16,820
+Okay السلام عليكم I hope this would be the last
+
+2
+00:00:16,820 --> 00:00:21,930
+lecture in bankruptcyand next week we have to
+
+3
+00:00:21,930 --> 00:00:24,030
+finalize all what we have and we can speak about
+
+4
+00:00:24,030 --> 00:00:28,710
+the exam but for now we have 10 slides to finish
+
+5
+00:00:28,710 --> 00:00:34,750
+or 11 slides in bankruptcy and we still talking
+
+6
+00:00:34,750 --> 00:00:37,170
+about bankruptcy in the UK, we finish with
+
+7
+00:00:37,170 --> 00:00:40,250
+bankruptcy in the USA and the general meaning and
+
+8
+00:00:40,250 --> 00:00:43,560
+concept of bankruptcyولكن اليوم بانكروبسيا في
+
+9
+00:00:43,560 --> 00:00:46,020
+الولايات المتحدة قلنا .. في الولايات المتحدة قلنا
+
+10
+00:00:46,020 --> 00:00:50,240
+إنها مخصصة، أحد يمكن أن يقبل لبنكروبسيا، فيما فيه
+
+11
+00:00:50,240 --> 00:00:53,380
+أنه أو أنها تشعر أنهم لا يمكنوا أن يدفعوا المال
+
+12
+00:00:53,380 --> 00:00:57,560
+لهم، فهم لا يمكنوا أن يقبلوا لبنكروبسيا، واحد من
+
+13
+00:00:57,560 --> 00:01:00,920
+الأسئلة التي يمكن أن يكون طرحها هنا هو عندما وكيف؟
+
+14
+00:01:01,640 --> 00:01:04,940
+لقد تحدثنا في السابق عن عندما نستطيع أن نطلع من
+
+15
+00:01:04,940 --> 00:01:09,780
+الانتجار في الواقع إن كان شخص ما في حاجة هناك مال
+
+16
+00:01:09,780 --> 00:01:12,580
+لم يكن قادر على التدفع و هذه الشخصية لم تستطيع أن
+
+17
+00:01:12,580 --> 00:01:18,780
+تدفعهم الآن قلنا أيضًا أننا يجب أن نستخدم المطالب
+
+18
+00:01:18,780 --> 00:01:22,560
+الذي يسمى مطالب الانتجار ولكن هذا المطالب الانتجار
+
+19
+00:01:22,560 --> 00:01:27,840
+يجب أن يتم إرساله إلى الحكومة إذا كان الحكومة في
+
+20
+00:01:27,840 --> 00:01:31,670
+الولايات المتحدةبإمكاننا أن نرسل مطالب الانفجار أو
+
+21
+00:01:31,670 --> 00:01:35,830
+ملف الانفجار يجب أن يتم إرساله إلى القاضية الخاصة
+
+22
+00:01:35,830 --> 00:01:39,890
+التي يمكن أن تكون القاضية العالية في لندن ويمكن أن
+
+23
+00:01:39,890 --> 00:01:45,630
+تكون القاضية المدينة في بلستان لدينا نفس الوضع يجب
+
+24
+00:01:45,630 --> 00:01:49,190
+أن نرسل مطالب الانفجار إلى القاضية المناسبة يمكن
+
+25
+00:01:49,190 --> 00:01:51,150
+أن يكون في مدينة غزا ويمكن أن يكون في نابلوس ويمكن
+
+26
+00:01:51,150 --> 00:01:56,970
+أن يكون في مكان آخر هذا يعتمد على المكان
+
+27
+00:01:58,340 --> 00:02:01,960
+of the data where he used to live if he was living
+
+28
+00:02:01,960 --> 00:02:04,940
+in Gaza city then we have to submit the file to
+
+29
+00:02:04,940 --> 00:02:08,520
+the Gaza city court if he was living in London we
+
+30
+00:02:08,520 --> 00:02:11,300
+have to send it to the high court of London or
+
+31
+00:02:11,300 --> 00:02:15,520
+county court near the place he used to live
+
+32
+00:02:15,520 --> 00:02:18,300
+location we look because we're not going to look
+
+33
+00:02:18,300 --> 00:02:21,120
+at the place where the creditors live we look at
+
+34
+00:02:21,120 --> 00:02:23,220
+the place where the debtor lives location the
+
+35
+00:02:23,220 --> 00:02:28,620
+house where he normally livesإذا لم يكن في البلد و
+
+36
+00:02:28,620 --> 00:02:34,580
+أحيانًا يحدث أن بعض الناس لديهم عمل أفضل و في وقت
+
+37
+00:02:34,580 --> 00:02:39,340
+الانفجار يهربوا و يغادروا البلد فإذا لم يكن موجود
+
+38
+00:02:39,340 --> 00:02:43,500
+في البلد إذا لم يكن يعيش هنا بعد الان يجب أن ننظر
+
+39
+00:02:43,500 --> 00:02:47,060
+في الماضي إلى المكان الذي كان يعيش فيه في الماضي
+
+40
+00:02:47,060 --> 00:02:50,860
+إذا كان يعيش في مدينة غزا فيجب أن نرسل رسالة
+
+41
+00:02:50,860 --> 00:02:52,660
+لإخباره
+
+42
+00:02:54,690 --> 00:02:59,230
+مقالات الانفجار يتم تحقيقها في الحكومة يجب أن نرسل
+
+43
+00:02:59,230 --> 00:03:04,310
+الوثيقة إلى المكان الذي كان يعيش فيه أو نستطيع أن
+
+44
+00:03:04,310 --> 00:03:07,770
+نرسله حتى نستطيع أن نرسله إلى المكان الذي كان يعيش
+
+45
+00:03:07,770 --> 00:03:11,930
+فيه لديه شركة اتصال شركة اتصال اللي كان يعيش فيه
+
+46
+00:03:11,930 --> 00:03:14,970
+لديه اتصال اذا كنت تريد أن تكون لديك شيء مثل هذا
+
+47
+00:03:14,970 --> 00:03:19,450
+تطلب الانفجار و أنت تفهم بالضبط ما يجب أن تفعله و
+
+48
+00:03:19,450 --> 00:03:22,410
+كيف ستفعله و في أي الحكومة التي يجب أن ترسل
+
+49
+00:03:22,410 --> 00:03:26,300
+الوثيقةو هناك بعض الوصفات و بعض المحللين اللي
+
+50
+00:03:26,300 --> 00:03:30,960
+يخبرك عن هذه الحالة بطريقة ما هناك وصفة هنا في
+
+51
+00:03:30,960 --> 00:03:33,560
+الولايات المتحدة فقط و في هذه الوصفة يمكنك أن تنظر
+
+52
+00:03:33,560 --> 00:03:37,680
+و تجد كيف يمكنك أن تشرح مصالح الانتجار أو مصالح
+
+53
+00:03:37,680 --> 00:03:43,800
+الانتجار لحكم محدد و بعد أن نشرح مصالح الانتجار
+
+54
+00:03:43,800 --> 00:03:47,280
+اللي يسمى مصالح الانتجار او مصالح الانتجار
+
+55
+00:03:47,280 --> 00:03:50,740
+فالحكومة ستقرر
+
+56
+00:03:52,470 --> 00:03:58,010
+هل يمكن تحقق تطبيق هذه التطبيقات من هذا الحكومة أو
+
+57
+00:03:58,010 --> 00:04:00,610
+لا؟ إذا كانت هذه الحكومة المناسبة، إذا كانت هذه
+
+58
+00:04:00,610 --> 00:04:04,770
+الحكومة لديها حكومة لتحقق حكومة المغامرة أو لا؟
+
+59
+00:04:04,770 --> 00:04:08,130
+إذا لم يكن، فهذا الفيديو يتم إرساله إلى الحكومة
+
+60
+00:04:08,130 --> 00:04:15,270
+المحددةإذا اكتشفت الحكومة في مدينة غزا أن الدكتور
+
+61
+00:04:15,270 --> 00:04:18,910
+كان يعيش في خان يونيس، فسيُرحل الملف كام لحكومة
+
+62
+00:04:18,910 --> 00:04:24,910
+خان يونيس. لذلك ننظر إلى حكومة الحكومة إذا كانت
+
+63
+00:04:24,910 --> 00:04:29,550
+ممكنة أن ننظر إلى حكومة الانقلاب أو لا. ثم في
+
+64
+00:04:29,550 --> 00:04:33,490
+المرحلة التالية، يجب أن نرى ما يحدث في الحكومة.
+
+65
+00:04:34,070 --> 00:04:41,460
+إذا قرر الحكومة أن حكومة حكومتها ومنطقةهاو يستطيع
+
+66
+00:04:41,460 --> 00:04:46,880
+أن ينظر إلى هذه التطبيقات ثم في السجن سنرى الآن
+
+67
+00:04:46,880 --> 00:04:52,900
+ماذا سيحدث ماذا تظن يمكن أن يحدث في السجن تخيل
+
+68
+00:04:52,900 --> 00:04:58,760
+أننا اليوم لدينا صفحة بانكرابسي صفحة بانكرابسي و
+
+69
+00:04:58,760 --> 00:05:04,500
+هذا الصفحة نرسله للسجن وكانت في مدينة غزا وكانت
+
+70
+00:05:04,500 --> 00:05:09,780
+مرة أخرى إسحانين كانت الشخص اللي نريده أن يكون
+
+71
+00:05:09,780 --> 00:05:18,900
+بانكرابتعن حالتك في مجال التجارب في مدينة غزا
+
+72
+00:05:18,900 --> 00:05:25,340
+هنا لدينا أحد أربع من أربع من الممكن أن يكون هناك
+
+73
+00:05:25,340 --> 00:05:31,400
+حلول ممكن أن يكون هناك حلول واحد من أربع ممكن أن
+
+74
+00:05:31,400 --> 00:05:34,400
+يكون هناك حلولإذا كانت أنت، ماذا يمكنك أن تفعل؟
+
+75
+00:05:34,400 --> 00:05:38,100
+اليوم لديك حالة مثل هذه أمامك التي تسمى بانكروبسي
+
+76
+00:05:38,100 --> 00:05:41,760
+ويجب أن تنظر إليها، ماذا يمكنك أن تفعل؟ هل يمكنك
+
+77
+00:05:41,760 --> 00:05:45,460
+أن تأخذ قرار من المجلس الأول؟ هل يمكنك أن تعلن عن
+
+78
+00:05:45,460 --> 00:05:48,040
+بانكروبسي؟ هل يمكنك أن تحصل على حرارة بانكروبسي؟
+
+79
+00:05:48,040 --> 00:05:52,720
+حرارة بانكروبسي هي القرار اللي تم إصلاحه القاضي
+
+80
+00:05:52,720 --> 00:05:58,400
+وهذه القرارة يعني أن هذا الشخص، المدفع يصبح مفلس
+
+81
+00:05:58,400 --> 00:06:03,050
+بانكروبسوهو يصبح مغامر على هذا الوقت، وكان مجرد
+
+82
+00:06:03,050 --> 00:06:06,790
+مغامر مجرد مجرد قرار مجرد قرار مجرد قرار مجرد قرار
+
+83
+00:06:06,790 --> 00:06:09,910
+مجرد قرار
+
+84
+00:06:09,910 --> 00:06:17,110
+مجرد قرار مجرد قرار مجرد قرار مجرد قرار مجرد قرار
+
+85
+00:06:17,110 --> 00:06:18,950
+مجرد قرار مجرد قرار مجرد قرار مجرد قرار مجرد قرار
+
+86
+00:06:18,950 --> 00:06:20,090
+مجرد قرار مجرد قرار مجرد قرار مجرد قرار مجرد قرار
+
+87
+00:06:20,090 --> 00:06:34,610
+مجرد قرار مجرد قرار مجرد قchance for what؟
+
+88
+00:06:34,610 --> 00:06:38,990
+we considering the whole case for more research
+
+89
+00:06:38,990 --> 00:06:44,190
+and more inspecting of the whole case؟ if you look
+
+90
+00:06:44,190 --> 00:06:47,630
+in Gaza for example here we have the courts most
+
+91
+00:06:47,630 --> 00:06:54,420
+likely they would delayوانتظر هناك وانتظر هناك
+
+92
+00:06:54,420 --> 00:06:58,620
+وانتظر هناك
+
+93
+00:06:58,620 --> 00:07:02,880
+وانتظر هناك وانتظر هناك وانتظر هناك وانتظر هناك
+
+94
+00:07:02,880 --> 00:07:03,580
+وانتظر هناك وانتظر هناك وانتظر هناك وانتظر هناك
+
+95
+00:07:03,580 --> 00:07:03,640
+وانتظر هناك وانتظر هناك وانتظر هناك وانتظر هناك
+
+96
+00:07:03,640 --> 00:07:03,720
+وانتظر هناك وانتظر هناك وانتظر هناك وانتظر هناك
+
+97
+00:07:03,720 --> 00:07:04,360
+وانتظر هناك وانتظر هناك وانتظر هناك وانتظر هناك
+
+98
+00:07:04,360 --> 00:07:05,920
+وانتظر هناك وانتظر هناك وانتظر هناك وانتظر هناك
+
+99
+00:07:05,920 --> 00:07:08,760
+وانتظر هناك
+
+100
+00:07:17,330 --> 00:07:21,210
+بسبب أن الحكومة تحتاج المزيد من المعلومات قبل أن
+
+101
+00:07:21,210 --> 00:07:26,870
+تتمكن من اختيار قرار عن الانتجار؟ نعم بالضبط أكثر
+
+102
+00:07:26,870 --> 00:07:29,510
+المستحيل أننا نحتاج المزيد من المعلومات لأن
+
+103
+00:07:29,510 --> 00:07:34,930
+التطبيق الذي تم تسمح به البيانات كانت تسمح بانتجار
+
+104
+00:07:34,930 --> 00:07:38,090
+تسمح ببيانات تسمح ببيانات تسمح ببيانات تسمح
+
+105
+00:07:38,090 --> 00:07:39,150
+ببيانات تسمح ببيانات تسمح ببيانات تسمح ببيانات
+
+106
+00:07:39,150 --> 00:07:40,110
+تسمح ببيانات تسمح ببيانات تسمح ببيانات تسمح
+
+107
+00:07:40,110 --> 00:07:40,250
+ببيانات تسمح ببيانات تسمح ببيانات تسمح ببيانات
+
+108
+00:07:40,250 --> 00:07:42,750
+تسمح ببيانات تسمح ببيانات تسمح ببيانات تسمح
+
+109
+00:07:42,750 --> 00:07:46,380
+ببيانات تسمح ببيWe need to know exactly what
+
+110
+00:07:46,380 --> 00:07:48,660
+happened to the amount of money which was
+
+111
+00:07:48,660 --> 00:07:51,300
+mentioned in page 2 for example We need to know
+
+112
+00:07:51,300 --> 00:07:54,980
+all details, we need to get some witnesses, we can
+
+113
+00:07:54,980 --> 00:07:58,060
+take some statements So what we can do, we can
+
+114
+00:07:58,060 --> 00:08:01,740
+delay, two weeks, four weeks, it depends on the
+
+115
+00:08:01,740 --> 00:08:04,720
+situation and it depends how much work the judge
+
+116
+00:08:04,720 --> 00:08:07,840
+can have, can delay the case for a few days or for
+
+117
+00:08:07,840 --> 00:08:11,380
+a few weeksالمرة القادمة سنحصل على أكتر معلومات
+
+118
+00:08:11,380 --> 00:08:14,140
+ونستطيع اختيار اختيار اختيار اختيار اختيار اختيار
+
+119
+00:08:14,140 --> 00:08:14,740
+اختيار اختيار اختيار اختيار اختيار اختيار اختيار
+
+120
+00:08:14,740 --> 00:08:16,800
+اختيار اختيار اختيار اختيار اختيار اختيار اختيار
+
+121
+00:08:16,800 --> 00:08:16,940
+اختيار اختيار اختيار اختيار اختيار اختيار اختيار
+
+122
+00:08:16,940 --> 00:08:19,880
+اختيار اختيار اختيار اختيار اختيار اختيار اختيار
+
+123
+00:08:19,880 --> 00:08:26,200
+اختيار اختيار اختيار اختيار اختيار اختيار اختيار
+
+124
+00:08:26,200 --> 00:08:29,360
+اختيار اختيار اختيار اختيار اختيار اختيار اختيار
+
+125
+00:08:29,360 --> 00:08:32,880
+اختيار اختيار ا
+
+126
+00:08:35,760 --> 00:08:40,100
+refuse، dismiss what؟ ده هو ال petition، we say
+
+127
+00:08:40,100 --> 00:08:43,560
+this petition we have some .. لأ لأحت الاتهام و
+
+128
+00:08:43,560 --> 00:08:48,620
+لأحت الدعوة، this petition is dismissedwe cannot
+
+129
+00:08:48,620 --> 00:08:51,500
+see it anymore we cannot look at it because this
+
+130
+00:08:51,500 --> 00:08:54,780
+is not appropriate we can dismiss petition perhaps
+
+131
+00:08:54,780 --> 00:08:58,840
+maybe maybe because administration order would be
+
+132
+00:08:58,840 --> 00:09:01,440
+more appropriate i know that you will not be
+
+133
+00:09:01,440 --> 00:09:04,640
+understand you will not understand such point if
+
+134
+00:09:04,640 --> 00:09:08,720
+you don't attend the class there is something
+
+135
+00:09:08,720 --> 00:09:11,360
+called administration order this we have to take
+
+136
+00:09:11,360 --> 00:09:15,940
+it after a few slides one of the alternativesأحد
+
+137
+00:09:15,940 --> 00:09:21,840
+التغييرات للمغامرة هي تسميها اتفاق إدارة إذا كان
+
+138
+00:09:21,840 --> 00:09:28,220
+المال في الوقت أقل من 5000 ريال أقل من 5000 ريال
+
+139
+00:09:28,220 --> 00:09:34,900
+فلا يوجد مغامرة اختيارها إذا كان المال أقل من 5000
+
+140
+00:09:34,900 --> 00:09:38,400
+ريال كل الوقت لا يوجد مغامرة يمكن أن يكون هناك
+
+141
+00:09:38,400 --> 00:09:42,970
+اتفاق إدارةهنا لا يوجد مغامرة، فالدكتور سيدفع
+
+142
+00:09:42,970 --> 00:09:48,290
+المدفعات للحكومة، حتى ينتهي كل المدفعات، لأن خمس
+
+143
+00:09:48,290 --> 00:09:52,270
+ألف دولار ليس كثير من المال، خمس ألف دولار يعني
+
+144
+00:09:52,270 --> 00:09:56,250
+حوالي اcht ألف دولار، ليس كثيرعندما يأتي الناس
+
+145
+00:09:56,250 --> 00:10:00,130
+للعمل و كان شخص ما ميت من 8000$ لكي يكون مغامر،
+
+146
+00:10:00,130 --> 00:10:03,590
+ليس صحيحًا، يمكن أن تعطي الشخص المزيد من الوقت و
+
+147
+00:10:03,590 --> 00:10:07,410
+المزيد من الوقت لتعطيه و هذا يمكن أن يكون واحد من
+
+148
+00:10:07,410 --> 00:10:10,630
+الأسباب، في بعض الأحيان، يمكن أن يتم إعادة
+
+149
+00:10:10,630 --> 00:10:12,230
+الموضوع، الموضوع يمكن أن يتم إعادة الموضوع،
+
+150
+00:10:12,230 --> 00:10:13,230
+الموضوع يمكن أن يتم إعادة الموضوع، الموضوع يمكن أن
+
+151
+00:10:13,230 --> 00:10:16,290
+يتم إعادة الموضوع، الموضوع يمكن أن يتم إعادة
+
+152
+00:10:16,290 --> 00:10:18,330
+الموضوع، الموضوع يمكن أن يتم إعادة الموضوع يمكن أن
+
+153
+00:10:18,330 --> 00:10:22,450
+يتم إعادة الموضوع يمكن أن يتم إعادة الموضbecause
+
+154
+00:10:22,450 --> 00:10:27,050
+maybe there was no reason to have bankruptcy maybe
+
+155
+00:10:27,050 --> 00:10:30,490
+because the debtor can prove that he can pay the
+
+156
+00:10:30,490 --> 00:10:33,050
+money for any reason it's up to the judge he can
+
+157
+00:10:33,050 --> 00:10:36,110
+decide because he have the discretion to decide if
+
+158
+00:10:36,110 --> 00:10:40,810
+we can take a decision like this or not if we can
+
+159
+00:10:40,810 --> 00:10:43,170
+take a decision of bankruptcy or can dismiss the
+
+160
+00:10:43,170 --> 00:10:47,410
+whole petition dismiss يعني إلغاء أو نترك القضية
+
+161
+00:10:47,410 --> 00:10:55,700
+نترك القضية خالصالثالث فرصة هي IVA إذا كنت لست
+
+162
+00:10:55,700 --> 00:10:59,320
+مدرسة ثالث
+
+163
+00:10:59,320 --> 00:11:05,060
+فرصة تسمى IVA كان لديناها السابق مرة IVA هي تجارب
+
+164
+00:11:05,060 --> 00:11:10,500
+فلانتري في هذه الحالة يمكن أن يقوم الشرطة بإدارة
+
+165
+00:11:10,500 --> 00:11:15,180
+هو ليس الشرطةSuggest that somebody which is called
+
+166
+00:11:15,180 --> 00:11:17,900
+insolvency practitioner which we're gonna look at
+
+167
+00:11:17,900 --> 00:11:21,960
+next slide to see He is the trustee which is
+
+168
+00:11:21,960 --> 00:11:23,960
+something important we have to keep in our mind
+
+169
+00:11:23,960 --> 00:11:27,980
+trustee Just
+
+170
+00:11:27,980 --> 00:11:30,620
+remind me after we finish here recording I'm gonna
+
+171
+00:11:30,620 --> 00:11:33,020
+talk about the exam just for two minutes which I'm
+
+172
+00:11:33,020 --> 00:11:34,300
+gonna explain sometimes you're gonna have
+
+173
+00:11:34,300 --> 00:11:38,120
+questions asking you to differentiate between two
+
+174
+00:11:38,120 --> 00:11:42,550
+thingsماذا يعني مثلًا؟ انفجار غير مفروض و غير
+
+175
+00:11:42,550 --> 00:11:47,190
+مفروض انفجار غير مفروض انفجار
+
+176
+00:11:47,190 --> 00:11:47,930
+غير مفروض انفجار غير مفروض انفجار غير مفروض انفجار
+
+177
+00:11:47,930 --> 00:11:48,530
+غير مفروض انفجار غير مفروض انفجار غير مفروض انفجار
+
+178
+00:11:48,530 --> 00:11:49,610
+غير مفروض انفجار غير مفروض انفجار غير مفروض انفجار
+
+179
+00:11:49,610 --> 00:11:50,010
+غير مفروض انفجار غير مفروض انفجار غير مفروض انفجار
+
+180
+00:11:50,010 --> 00:12:06,670
+غير مفروض انفجار غير مفروض انفجار غير مفروض انفجار
+
+181
+00:12:06,670 --> 00:12:11,930
+غير مهناك سبب لإصلاح أن هذا الـ debtor يمكن أن
+
+182
+00:12:11,930 --> 00:12:14,630
+يدفع المال مرة أخرى ولكنه سيحتاج المزيد من الوقت
+
+183
+00:12:14,630 --> 00:12:18,690
+كما شهدنا بالأسباب السابقة في هذه الحالة نستطيع أن
+
+184
+00:12:18,690 --> 00:12:23,350
+ندفع مؤسسة في هذه الحالة مؤسسة اسمها Insolvency
+
+185
+00:12:23,350 --> 00:12:26,310
+Practitioner يمكن أن يكون مستخدم يمكن أن يكون
+
+186
+00:12:26,310 --> 00:12:32,090
+مستخدم او اي شخص آخر هذا الشخص مع الـ debtor سيصنع
+
+187
+00:12:32,090 --> 00:12:36,570
+برنامج اقتراح ويقوم بإعطاء كل المعلومات المحتاجة
+
+188
+00:12:37,890 --> 00:12:41,810
+القانون الاجتماعي والمال والمال اللي لدينا
+
+189
+00:12:41,810 --> 00:12:45,430
+والسيارات كل شيء اللي لدينا يجب أن يكون مصطلح في
+
+190
+00:12:45,430 --> 00:12:53,110
+قطع كتابة ويقوم بتصميمها للمستخدمين لو اقبلوا هذا
+
+191
+00:12:53,110 --> 00:12:57,770
+الانتجار كما يجب أن نشرحه في أكتر تفاصيل بعد 2 او
+
+192
+00:12:57,770 --> 00:13:02,610
+3 أسلوب اذا اقبلوا هذا الانتجار فسيكون لدينا IVA
+
+193
+00:13:03,340 --> 00:13:06,480
+وبعد ذلك يجب أن نرسلها إلى الحكومة لإعطائها وليس
+
+194
+00:13:06,480 --> 00:13:10,140
+بانكروبسيا، لذا رقم واحد، اثنان، ثلاثة، لا قرار
+
+195
+00:13:10,140 --> 00:13:13,580
+بانكروبسيا يمكن أن يتم إصلاحه، لا، لأن خيار
+
+196
+00:13:13,580 --> 00:13:18,100
+الأخير، الفرصة الأخيرة هي إجراء حركة بانكروبسيا،
+
+197
+00:13:18,100 --> 00:13:24,660
+يجب أن نبقى به إلى الأخير، يجب أن نستخدم جميع
+
+198
+00:13:24,660 --> 00:13:29,120
+الاختيارات في البداية، لأن حركة بانكروبسياIt means
+
+199
+00:13:29,120 --> 00:13:33,020
+the end of the life the end of business life then
+
+200
+00:13:33,020 --> 00:13:34,780
+we will not be able to come back to business
+
+201
+00:13:34,780 --> 00:13:41,360
+easily in the future last option for the judge is
+
+202
+00:13:41,360 --> 00:13:49,100
+bankruptcy order bankruptcy decision judgment this
+
+203
+00:13:49,100 --> 00:13:52,790
+is the final decision can beوهو مجرد قانون مجرد
+
+204
+00:13:52,790 --> 00:13:54,230
+قانون مجرد قانون مجرد قانون مجرد قانون مجرد قانون
+
+205
+00:13:54,230 --> 00:13:57,050
+مجرد قانون مجرد قانون مجرد قانون مجرد قانون مجرد
+
+206
+00:13:57,050 --> 00:14:00,150
+قانون مجرد قانون مجرد قانون مجرد قانون مجرد قانون
+
+207
+00:14:00,150 --> 00:14:01,410
+مجرد قانون مجرد قانون مجرد قانون مجرد قانون مجرد
+
+208
+00:14:01,410 --> 00:14:06,830
+قانون مجرد قانون مجرد قانون مجرد قانون مجرد قانون
+
+209
+00:14:06,830 --> 00:14:08,330
+مجرد قانون مجرد قانون مجرد قانون مجرد قانون مجرد
+
+210
+00:14:08,330 --> 00:14:15,650
+قانون مجرد قانون مجرد قانون مجرد
+
+211
+00:14:23,300 --> 00:14:26,320
+سبسكتفات ممكن تتم إصدارها من الحكومة، إذا لم تكن
+
+212
+00:14:26,320 --> 00:14:31,280
+المال عالي، إذا لم تكن المال أقل من 20 ألف pound،
+
+213
+00:14:31,280 --> 00:14:34,460
+أعني في الانتجار، الناس أحيانًا يمكن أن تكون مالية
+
+214
+00:14:34,460 --> 00:14:40,920
+مليون دولارعشان عشان عشان عشان عشان عشان عشان عشان
+
+215
+00:14:40,920 --> 00:14:41,560
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+216
+00:14:41,560 --> 00:14:41,940
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+217
+00:14:41,940 --> 00:14:41,980
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+218
+00:14:41,980 --> 00:14:42,020
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+219
+00:14:42,020 --> 00:15:04,960
+عشان عشان عشان عشان عشان عشان عش
+
+220
+00:15:05,390 --> 00:15:10,870
+هو لم يقبل IVA في هذه الحالة سوف نعطيه برنامج هذا
+
+221
+00:15:10,870 --> 00:15:16,270
+البرنامج سيساعد في تسريع البرنامج هذا البرنامج
+
+222
+00:15:16,270 --> 00:15:19,170
+سيساعد في تسريع البرنامج الوثيق الوثيق الوثيق
+
+223
+00:15:19,170 --> 00:15:22,110
+الوثيق الوثيق الوثيق الوثيق الوثيق الوثيق الوثيق
+
+224
+00:15:22,110 --> 00:15:23,950
+الوثيق الوثيق الوثيق الوثيق الوثيق الوثيق الوثيق
+
+225
+00:15:23,950 --> 00:15:24,010
+الوثيق الوثيق الوثيق الوثيق الوثيق الوثيق الوثيق
+
+226
+00:15:24,010 --> 00:15:30,150
+الوثيق الوثيق الوثيق الوثيق الوثيق الوثيق الوثيق
+
+227
+00:15:30,150 --> 00:15:34,450
+الو
+
+228
+00:15:34,720 --> 00:15:39,620
+ممكن تبقى 3 سنة و انا سأشرح كيف يمكن ان يكون هذا
+
+229
+00:15:39,620 --> 00:15:48,180
+الوضع اذا كان لدينا امرتكاب اذا كان لدينا
+
+230
+00:15:48,180 --> 00:15:51,060
+امرتكاب اذا كان لدينا امرتكاب اذا كان لدينا
+
+231
+00:15:51,060 --> 00:15:51,460
+امرتكاب اذا كان لدينا امرتكاب اذا كان لدينا
+
+232
+00:15:51,460 --> 00:15:52,620
+امرتكاب اذا كان لدينا امرتكاب اذا كان لدينا
+
+233
+00:15:52,620 --> 00:15:53,220
+امرتكاب اذا كان لدينا امرتكاب اذا كان لدينا
+
+234
+00:15:53,220 --> 00:15:53,500
+امرتكاب اذا كان لدينا امرتكاب اذا كان لدينا
+
+235
+00:15:53,500 --> 00:15:54,160
+امرتكاب اذا كان لدينا امرتكاب اذا كان لدينا
+
+236
+00:15:54,160 --> 00:15:56,520
+امرتكاب اذا كان لدينا امرتكاب اذا كان لدينا
+
+237
+00:15:56,520 --> 00:15:59,260
+امرتكاب اذا كان لدينا امرتكاب اذا كان لدينا امر
+
+238
+00:15:59,750 --> 00:16:01,590
+عندما تحصل على قيمة صغيرة من المال، فيمكنك أن
+
+239
+00:16:01,590 --> 00:16:10,690
+تتجارب بعد 12 أشهر، وهو سيكون هنا في 2002 من
+
+240
+00:16:10,690 --> 00:16:14,150
+اليوم عندما تحصل على حرارة، فتصبح حرارة، أليس
+
+241
+00:16:14,150 --> 00:16:21,010
+كذلك؟ أفضل أن تصبح حرارة من وقت الحرارة
+
+242
+00:16:22,560 --> 00:16:27,840
+ولكن عندما تكون لديك دستجارة دستجارة يعني حرية لا
+
+243
+00:16:27,840 --> 00:16:32,240
+أحد يمكن يطلب منك أي شيء في هذه الوقت هذا يمكن أن
+
+244
+00:16:32,240 --> 00:16:35,200
+يكون أحيانا يمكن أن يكون عامة يمكن أن يكون عامتين
+
+245
+00:16:35,200 --> 00:16:36,260
+يمكن أن يكون عامتين يمكن أن يكون عامتين يمكن أن
+
+246
+00:16:36,260 --> 00:16:36,560
+يكون عامتين يمكن أن يكون عامتين يمكن أن يكون
+
+247
+00:16:36,560 --> 00:16:36,720
+عامتين يمكن أن يكون عامتين يمكن أن يكون عامتين
+
+248
+00:16:36,720 --> 00:16:37,280
+يمكن أن يكون عامتين يمكن أن يكون عامتين يمكن أن
+
+249
+00:16:37,280 --> 00:16:37,640
+يكون عامتين يمكن أن يكون عامتين يمكن أن يكون
+
+250
+00:16:37,640 --> 00:16:38,620
+عامتين يمكن أن يكون عامتين يمكن أن يكون عامتين
+
+251
+00:16:38,620 --> 00:16:41,780
+يمكن أن يكون عامتين يمكن أن يكون عامتين يمكن أن
+
+252
+00:16:41,780 --> 00:16:50,000
+يكون عامتين ي
+
+253
+00:16:50,690 --> 00:16:54,290
+إذا كان هذا الشخص يخاطر، فهناك عديد من الأسباب
+
+254
+00:16:54,290 --> 00:16:57,330
+التي يمكن أن يستخدمها القاضي و يقوم باختياره نفسه
+
+255
+00:16:57,330 --> 00:17:05,690
+الأقل من الوقت يمكن أن يكون 12 أشهر أو 1 عام في
+
+256
+00:17:05,690 --> 00:17:10,150
+الواقع إذا كنت مغامر بعد 1 عام، يمكنني الذهاب إلى
+
+257
+00:17:10,150 --> 00:17:13,230
+الحجر لديه تجارب تجارب افراطية الأفراطية الأفراطية
+
+258
+00:17:13,230 --> 00:17:13,290
+الأفراطية الأفراطية الأفراطية الأفراطية الأفراطية
+
+259
+00:17:13,290 --> 00:17:14,430
+الأفراطية الأفراطية الأفراطية الأفراطية الأفراطية
+
+260
+00:17:14,430 --> 00:17:15,130
+الأفراطية الأفراطية الأفراطية الأفراطية الأفراطية
+
+261
+00:17:15,130 --> 00:17:16,710
+الأفراطية الأفراطية الأفراطية الأفراطية الأفراطية
+
+262
+00:17:16,710 --> 00:17:21,520
+الأفهذا يمكن أن يكون سنة او اثنين او اثنين او
+
+263
+00:17:21,520 --> 00:17:21,820
+اثنين او اثنين او اثنين او اثنين او اثنين او اثنين
+
+264
+00:17:21,820 --> 00:17:24,660
+او اثنين او اثنين او اثنين او اثنين او اثنين او
+
+265
+00:17:24,660 --> 00:17:25,500
+اثنين او اثنين او اثنين او اثنين او اثنين او اثنين
+
+266
+00:17:25,500 --> 00:17:26,260
+او اثنين او اثنين او اثنين او اثنين او اثنين او
+
+267
+00:17:26,260 --> 00:17:27,520
+اثنين او اثنين او اثنين او اثنين او اثنين او اثنين
+
+268
+00:17:27,520 --> 00:17:46,380
+او اثنين او اثنين او اثنين او اثنين او اثنين او
+
+269
+00:17:46,380 --> 00:17:51,880
+اثوهو ما يسمى كثيرا من الأسات غير مفتوحة في وقت ما
+
+270
+00:17:51,880 --> 00:17:56,380
+بعد تحويل الشركة حتى يكون لدينا هذه التحويلة اي
+
+271
+00:17:56,380 --> 00:17:59,900
+أكتر المال اللي يجعله الشركة تحويله يمكنك أن تحصل
+
+272
+00:17:59,900 --> 00:18:02,960
+على شيء مثل ما سنشاهده في التعليقات القادمة اي
+
+273
+00:18:02,960 --> 00:18:07,720
+أكتر المال اللي يجعله تحويله سيأخذه منه ويعطيه
+
+274
+00:18:07,720 --> 00:18:10,280
+للتواصل اللي يجعله تحويله اكتر المال اللي يجعله
+
+275
+00:18:10,280 --> 00:18:13,120
+تحويله تحويله
+
+276
+00:18:13,650 --> 00:18:16,790
+أنت لن تدفعه، نعرف الفرق بين الانتجار والانتجار
+
+277
+00:18:16,790 --> 00:18:19,710
+الانتجار وليس الانتجار، هل كذلك؟ نحن لدينا أساتذ
+
+278
+00:18:19,710 --> 00:18:22,470
+انتجار وليس انتجار وليس انتجار وليس انتجار وليس
+
+279
+00:18:22,470 --> 00:18:22,690
+انتجار وليس انتجار وليس انتجار وليس انتجار وليس
+
+280
+00:18:22,690 --> 00:18:24,030
+انتجار وليس انتجار وليس انتجار وليس انتجار وليس
+
+281
+00:18:24,030 --> 00:18:34,410
+انتجار وليس انتجار وليس انتجار وليس
+
+282
+00:18:34,410 --> 00:18:38,790
+انتجار وليس انتجار وليس انتجار وليس انتجار وليس
+
+283
+00:18:38,790 --> 00:18:41,710
+انتجار وليس انتجار وليس انتجار وليس انتجار وليس
+
+284
+00:18:41,710 --> 00:18:47,410
+انتجار وليعندما تكون لديك أساتذة غير مجالية حتى
+
+285
+00:18:47,410 --> 00:18:51,250
+وقت أن تكون لديك استخدام فإن المال الأكتر اللي
+
+286
+00:18:51,250 --> 00:18:55,410
+تدفعه سيكون أعطيه للمؤسسة ولكن عندما تكون لديك
+
+287
+00:18:55,410 --> 00:18:57,670
+استخدام فإن تكون لديك استخدام فإن تكون لديك
+
+288
+00:18:57,670 --> 00:18:58,870
+استخدام فإن تكون لديك استخدام فإن تكون لديك
+
+289
+00:18:58,870 --> 00:19:02,810
+استخدام فإن تكون لديك استخدام فإن تكون لديك
+
+290
+00:19:02,810 --> 00:19:05,350
+استخدام فإن تكون لديك استخدام فإن تكون لديك
+
+291
+00:19:05,350 --> 00:19:07,410
+استخدام فإن تكون لديك استخدام فإن تكون لديك
+
+292
+00:19:07,410 --> 00:19:10,030
+استخدام فإن تكون لديك استخدام فإن تكون لديك
+
+293
+00:19:10,030 --> 00:19:11,570
+استخدام فإن
+
+294
+00:19:15,240 --> 00:19:17,680
+الان كما ترى نحن لدينا اثنين نوع من المصادر
+
+295
+00:19:17,680 --> 00:19:22,420
+المصادر هما اثنين و هذا يمكن أن يكون سؤال الاختلاف
+
+296
+00:19:22,420 --> 00:19:28,840
+بين اثنين مصادر رقم واحد يسمى مصادر مصادر مصادر و
+
+297
+00:19:28,840 --> 00:19:30,440
+اخر مصادر مصادر مصادر مصادر و اخر مصادر مصادر
+
+298
+00:19:30,440 --> 00:19:34,160
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+299
+00:19:34,160 --> 00:19:37,740
+مصادر مصادر
+
+300
+00:19:37,740 --> 00:19:41,080
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+301
+00:19:41,080 --> 00:19:45,180
+مصادر مصادر مصادرالمستخدم الواضح هو شخص يعني شخص
+
+302
+00:19:45,180 --> 00:19:46,080
+يعني شخص يعني شخص يعني شخص يعني شخص يعني شخص يعني
+
+303
+00:19:46,080 --> 00:19:46,680
+شخص يعني شخص يعني شخص يعني شخص يعني شخص يعني شخص
+
+304
+00:19:46,680 --> 00:19:48,440
+يعني شخص يعني شخص يعني شخص يعني شخص يعني شخص يعني
+
+305
+00:19:48,440 --> 00:19:49,540
+شخص يعني شخص يعني شخص يعني شخص يعني شخص يعني شخص
+
+306
+00:19:49,540 --> 00:19:51,220
+يعني شخص يعني شخص يعني شخص يعني شخص يعني شخص يعني
+
+307
+00:19:51,220 --> 00:19:51,900
+شخص يعني شخص يعني شخص يعني شخص يعني شخص يعني شخص
+
+308
+00:19:51,900 --> 00:19:54,140
+يعني شخص يعني شخص يعني شخص يعني شخص يعني شخص يعني
+
+309
+00:19:54,140 --> 00:19:59,960
+شخص يعني شخص
+
+310
+00:19:59,960 --> 00:20:07,500
+يعني شخص
+
+311
+00:20:07,500 --> 00:20:11,850
+يعالثانية الوظائف هنا انظر إلى الوظائف هذا يمكن أن
+
+312
+00:20:11,850 --> 00:20:18,270
+يكون ملحق مستخدم مستخدم مستخدم مستخدم من من؟ من
+
+313
+00:20:18,270 --> 00:20:22,250
+الحكومة الحكومة ولكن هذا المستخدم الانسولفانسي
+
+314
+00:20:22,250 --> 00:20:28,470
+ملحق من ال .. من البيانات ملحق من الحكومة وملحق من
+
+315
+00:20:28,470 --> 00:20:34,110
+البيانات بالإضافة
+
+316
+00:20:34,110 --> 00:20:40,080
+إلى هذا ماذا يفعلون؟ ماذا تفعلون؟مهمة مستخدم الـ
+
+317
+00:20:40,080 --> 00:20:47,080
+official receiver هو إجراء المال، إجراء المواد،
+
+318
+00:20:47,080 --> 00:20:50,420
+وهو ما يسمى بـ Bankruptcy Estate كما كانت قبلها،
+
+319
+00:20:50,420 --> 00:20:55,060
+وهو ما يسمى بـ Bankruptcy Estate كل المال، المال
+
+320
+00:20:55,060 --> 00:21:00,020
+والمواد الخاصة بالبيانات، يتم إجراءها الـ official
+
+321
+00:21:00,020 --> 00:21:07,550
+receiverوهو سيكون شخص مثقف عن المال وينظر إلى كل
+
+322
+00:21:07,550 --> 00:21:13,430
+شيء ويقوم بتجارب يمكنه أن يقوم بتقليل المال ويقوم
+
+323
+00:21:13,430 --> 00:21:14,170
+بتقليل المال ويقوم بتقليل المال ويقوم بتقليل المال
+
+324
+00:21:14,170 --> 00:21:14,770
+ويقوم بتقليل المال ويقوم بتقليل المال ويقوم بتقليل
+
+325
+00:21:14,770 --> 00:21:16,010
+المال ويقوم بتقليل المال ويقوم بتقليل المال ويقوم
+
+326
+00:21:16,010 --> 00:21:16,110
+بتقليل المال ويقوم بتقليل المال ويقوم بتقليل المال
+
+327
+00:21:16,110 --> 00:21:16,150
+ويقوم بتقليل المال ويقوم بتقليل المال ويقوم بتقليل
+
+328
+00:21:16,150 --> 00:21:19,830
+المال ويقوم بتقليل المال ويقوم بتقليل المال ويقوم
+
+329
+00:21:19,830 --> 00:21:24,070
+بتقليل المال ويقوم بتقليلالدتر يقوم بالمخطط،
+
+330
+00:21:24,070 --> 00:21:31,490
+بمخطط، بمفهوم، بمساعدة الدتر، كما يقوم الدتر
+
+331
+00:21:31,490 --> 00:21:34,670
+بمخطط، بمخطط، بمساعدة الدتر، كما يقوم الدتر بمخطط،
+
+332
+00:21:34,670 --> 00:21:37,570
+بمخطط، بمساعدة الدتر، كما يقوم الدتر بمخطط، بمخطط،
+
+333
+00:21:37,570 --> 00:21:38,150
+بمساعدة الدتر، كما يقوم الدتر بمخطط، بمساعدة
+
+334
+00:21:38,150 --> 00:21:38,750
+الدتر، كما يقوم الدتر بمخطط، بمساعدة الدتر، كما
+
+335
+00:21:38,750 --> 00:21:40,150
+يقوم الدتر بمخطط، بمساعدة الدتر، كما يقوم الدتر
+
+336
+00:21:40,150 --> 00:21:45,190
+بمخطط، بمساعدة الدتر، كماوهو ري .. ري .. لا ري با
+
+337
+00:21:45,190 --> 00:21:48,630
+.. ري با .. ري با .. ري با .. ري با .. ري با .. ري
+
+338
+00:21:48,630 --> 00:21:50,450
+با .. ري با .. ري با .. ري با .. ري با .. ري با ..
+
+339
+00:21:50,450 --> 00:21:51,250
+ري با .. ري با .. ري با .. ري با .. ري با .. ري با
+
+340
+00:21:51,250 --> 00:21:51,630
+.. ري با .. ري با .. ري با .. ري با .. ري با .. ري
+
+341
+00:21:51,630 --> 00:21:51,910
+با .. ري با .. ري با .. ري با .. ري با .. ري با ..
+
+342
+00:21:51,910 --> 00:21:53,250
+ري با .. ري با .. ري با .. ري با .. ري با .. ري با
+
+343
+00:21:53,250 --> 00:21:57,390
+.. ري با .. ري با .. ري با .. ري با .. ري با .. ري
+
+344
+00:21:57,390 --> 00:22:08,850
+با .. ري با .. ري
+
+345
+00:22:08,850 --> 00:22:12,300
+بانحن نستطيع أن نحصل على موضوع جديد يمكن أن يكون
+
+346
+00:22:12,300 --> 00:22:17,120
+لعامين او ثلاث عامين فهو مختلف عن تجارب مجتمع
+
+347
+00:22:17,120 --> 00:22:22,240
+مجتمع مجتمع مجتمع لا هذا بالطبع هذا هو نقطة جيدة
+
+348
+00:22:22,240 --> 00:22:25,280
+أعني هذا هو تجارب مجتمع مجتمع مجتمع اكتشاف مجتمع
+
+349
+00:22:25,280 --> 00:22:26,680
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+350
+00:22:26,680 --> 00:22:27,580
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+351
+00:22:27,580 --> 00:22:28,960
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+352
+00:22:28,960 --> 00:22:38,020
+مجتمع مجتمع مجتمع مجتمع مجتمع
+
+353
+00:22:39,680 --> 00:22:43,220
+هو ليس صعبًا لدينا أربع اختلافات، هل يمكننا أن
+
+354
+00:22:43,220 --> 00:22:46,320
+نرىها مرة أخرى؟ رقم أول، هذا المستخدم الرئيسي هو
+
+355
+00:22:46,320 --> 00:22:52,800
+مستخدم مجتمع مستخدم مستخدم مستخدم مستخدم مستخدم
+
+356
+00:22:52,800 --> 00:22:57,740
+مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم
+
+357
+00:22:57,740 --> 00:22:59,360
+مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم
+
+358
+00:22:59,360 --> 00:23:01,500
+مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم
+
+359
+00:23:01,500 --> 00:23:09,020
+مستانسلفانسي مدرسة في تجارب تجارب او IVA لان تجارب
+
+360
+00:23:09,020 --> 00:23:12,100
+تجارب و IVA هي الشيء اللي هي الشيء اللي هي الشيء
+
+361
+00:23:12,100 --> 00:23:17,200
+الواقعي المستخدم سيأخذ المال و يقوم بتقليل بين
+
+362
+00:23:17,200 --> 00:23:22,120
+الانسلفانسي مدرسة انسلفانسي مدرسة انسلفانسي مدرسة
+
+363
+00:23:22,120 --> 00:23:26,660
+انسلفانسي مدرسة انسلفانسي مدرسة انسلفانسي مدرسة
+
+364
+00:23:26,660 --> 00:23:30,240
+انسلفانسي
+
+365
+00:23:30,240 --> 00:23:30,280
+مدرسة انسلفانسي مدرسة انسلفانسي مدرسة انسلفانسي
+
+366
+00:23:30,280 --> 00:23:34,890
+مدرسة انسلفانسي مدرسة انسلفانسي مدرسةالذي سيخبر
+
+367
+00:23:34,890 --> 00:23:39,970
+الحرس و المالكين كيف نستطيع أن نعيدهم في المستقبل
+
+368
+00:23:39,970 --> 00:23:47,610
+عندما
+
+369
+00:23:47,610 --> 00:23:57,490
+يصبح ال data مخفف عندما يصبح ال data مخفف
+
+370
+00:24:02,570 --> 00:24:08,890
+وان ده كانبيه؟ وان دي court
+
+371
+00:24:08,890 --> 00:24:12,670
+made
+
+372
+00:24:12,670 --> 00:24:15,890
+the order for the bankrupts؟ when .. well the
+
+373
+00:24:15,890 --> 00:24:19,550
+dictator becomes bankrupt once we have bankruptcy
+
+374
+00:24:19,550 --> 00:24:20,090
+order
+
+375
+00:24:23,180 --> 00:24:26,780
+من هذه اللحظة، من قرار الانفجار عندما تم صنعه،
+
+376
+00:24:26,780 --> 00:24:30,080
+الراجل أو الفتاة اللي كانت قائدها قبلها، تصبح
+
+377
+00:24:30,080 --> 00:24:34,020
+انفجار، خلاص، قرار تم صنعه من قبل الحكومة، نحن
+
+378
+00:24:34,020 --> 00:24:36,260
+لدينا بعض الواجهات، و هذه يمكن أن تكون أسئلة
+
+379
+00:24:36,260 --> 00:24:38,180
+للحكومة، مثل الـ true أو الfalse، تستطيع أن
+
+380
+00:24:38,180 --> 00:24:43,240
+تذكرهم، تستطيع أن تتكلم عنهم، الواجهات، إذا أصبحت
+
+381
+00:24:43,240 --> 00:24:48,240
+انفجار، ماذا تتوقع؟ ماذا يمكن أن تفعل؟ أحد يصبح
+
+382
+00:24:48,240 --> 00:24:50,320
+انفجار، ماذا يمكن أن يفعل؟
+
+383
+00:24:54,680 --> 00:24:57,200
+even without looking, just think about it for a
+
+384
+00:24:57,200 --> 00:25:01,800
+minute, a bankrupt can do something? of course he
+
+385
+00:25:01,800 --> 00:25:02,100
+can do
+
+386
+00:25:05,400 --> 00:25:08,560
+يعني after he's bankrupted .. yes after and even
+
+387
+00:25:08,560 --> 00:25:14,000
+before يعني the duties .. he said that the debitor
+
+388
+00:25:14,000 --> 00:25:19,460
+has become bankrupted and talked with him and he's
+
+389
+00:25:19,460 --> 00:25:23,360
+a .. الفستي اللي هو الconvincive practitioners
+
+390
+00:25:23,360 --> 00:25:32,260
+okay he came again to the business okayThe
+
+391
+00:25:32,260 --> 00:25:35,920
+bankrupt must provide an information to the
+
+392
+00:25:35,920 --> 00:25:39,340
+official .. to the official professor .. to the
+
+393
+00:25:39,340 --> 00:25:42,820
+official about the financial information about it.
+
+394
+00:25:42,920 --> 00:25:46,380
+Okay that's one yeah. If he has an assets, he can
+
+395
+00:25:46,380 --> 00:25:52,930
+pay them and pay his ..مثلًا قالت أن جميع الأساسات
+
+396
+00:25:52,930 --> 00:25:59,190
+غير مجالية يجب أن يتم إعطائها للمجلد و بينما يتم
+
+397
+00:25:59,190 --> 00:26:03,610
+إعطائه المال المجاني والذي يجب أن يتم إعطائه
+
+398
+00:26:03,610 --> 00:26:08,030
+المجلد هو نفس الشيء يجب أن يتعامل مع الحكومة
+
+399
+00:26:08,030 --> 00:26:12,670
+ويعطيه الاناليزية الاناليزية حسنًا لذلك يجب أن
+
+400
+00:26:12,670 --> 00:26:18,170
+يتعامل مع الحكومة تمامًا المال الذي يصبح مغامر يجب
+
+401
+00:26:18,170 --> 00:26:22,170
+أن يعطي كل ما لدينا هنا في هذه النقطة الأولىيجب أن
+
+402
+00:26:22,170 --> 00:26:27,350
+يمنح المستخدم المصطلح كل المعلومات المحتاجة في
+
+403
+00:26:27,350 --> 00:26:32,690
+الأعمال الانترنتية خلال 21 أيام منذ الوقت الذي كان
+
+404
+00:26:32,690 --> 00:26:37,530
+طلبه منذ الوقت عندما المستخدم عندما المستخدم طلب
+
+405
+00:26:37,530 --> 00:26:40,010
+من المصطلح الانترنتي أن يطلب من البيانات أن تمنحه
+
+406
+00:26:40,010 --> 00:26:43,510
+المعلومات عن المجالات الانترنتية يجب أن يفعل ذلك
+
+407
+00:26:43,510 --> 00:26:51,440
+إذا لم يستطيع إذا لم يتعاونالتأثير سيكون عظيم يمكن
+
+408
+00:26:51,440 --> 00:26:56,060
+أن يكون مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+409
+00:26:56,060 --> 00:26:56,860
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+410
+00:26:56,860 --> 00:26:57,720
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+411
+00:26:57,720 --> 00:26:57,740
+مجرد مجرد مجرد مجرد
+
+412
+00:27:18,360 --> 00:27:21,180
+even if the assets were not related to the same
+
+413
+00:27:21,180 --> 00:27:25,280
+company he's .. no we're not talking about the
+
+414
+00:27:25,280 --> 00:27:27,360
+person it doesn't matter if it's a company or
+
+415
+00:27:27,360 --> 00:27:31,320
+human being if he was bankrupt because this
+
+416
+00:27:31,320 --> 00:27:34,020
+certain company and he has other companies the
+
+417
+00:27:34,020 --> 00:27:36,520
+assets of the other companies are handed to this
+
+418
+00:27:36,520 --> 00:27:38,340
+person no it's not like this you did not
+
+419
+00:27:38,340 --> 00:27:40,000
+understand the whole point from the beginning
+
+420
+00:27:40,000 --> 00:27:45,210
+bankruptcyوهو من يستطيع أن يطلب الانقلاب، اي شخص
+
+421
+00:27:45,210 --> 00:27:48,330
+يمكن أن يكون إنسان يمكن أن يكون فكتشس مثل شركة،
+
+422
+00:27:48,330 --> 00:27:52,550
+الآن هذا الشخص اللي تتكلم عنه، انه طلب انقلاب،
+
+423
+00:27:52,550 --> 00:27:55,450
+أليس كذلك؟ او انك تقول انه لديه شركة مختلفة، شركة
+
+424
+00:27:55,450 --> 00:27:59,010
+أخرى، الآن الشركة الأولى، إنها شركة مشاركة ربما،
+
+425
+00:27:59,010 --> 00:28:02,950
+لذلك لديها عقل غير محدد، ثم تصبح انقلاب، ثم يجب أن
+
+426
+00:28:02,950 --> 00:28:07,190
+تكون كل ما لديكأي شيء من المال غير مجلس ولكن
+
+427
+00:28:07,190 --> 00:28:12,150
+الشركة الثانية اللي تتكلم عنها تكون مثلا قيمة
+
+428
+00:28:12,150 --> 00:28:16,790
+محددة او اي شركة لديها اسم افضل انها شخصية مختلفة
+
+429
+00:28:16,790 --> 00:28:23,670
+شركة لديها اسم افضل نحن لا نستطيع نستطيع نأخذ
+
+430
+00:28:23,670 --> 00:28:27,070
+المال من الشخص الثاني انه ليس كذلك نحن نحكم في شخص
+
+431
+00:28:27,070 --> 00:28:30,390
+ما ان هذا الشخص فقد فقد فقد فقد فقد فقد فقد فقد
+
+432
+00:28:30,390 --> 00:28:31,050
+فقد فقد فقد فقد فقد فقد فقد فقد فقد فقد فقد فقد
+
+433
+00:28:31,050 --> 00:28:35,010
+فقد فقد فقد فقد فقد فقد فقد فقد فقد فقد
+
+434
+00:28:35,010 --> 00:28:37,630
+فقد فقد فقد فقد فقد فقد فhe might have some shares
+
+435
+00:28:37,630 --> 00:28:40,530
+if he have some shares in a different company then
+
+436
+00:28:40,530 --> 00:28:43,530
+we can take his shares we can sell them but that
+
+437
+00:28:43,530 --> 00:28:46,190
+company it can be like you know I cannot own a
+
+438
+00:28:46,190 --> 00:28:49,190
+company myself unless if it's a limited liability
+
+439
+00:28:49,190 --> 00:28:52,330
+company like we said in the statesأو شركة شركة
+
+440
+00:28:52,330 --> 00:28:53,070
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+441
+00:28:53,070 --> 00:28:59,130
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+442
+00:28:59,130 --> 00:29:02,530
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+443
+00:29:02,530 --> 00:29:02,550
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+444
+00:29:02,550 --> 00:29:04,190
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+445
+00:29:04,190 --> 00:29:06,510
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+446
+00:29:06,510 --> 00:29:18,670
+شركة شركة
+
+447
+00:29:19,960 --> 00:29:26,720
+عندما يحدث هذا و أننا قررنا أن نتخلص من العرض، حتى
+
+448
+00:29:26,720 --> 00:29:31,920
+بعد ذلك، خلال التخلص، خلال التخلص، هذا ما يمكن أن
+
+449
+00:29:31,920 --> 00:29:34,900
+يكون قبل أن يكون لدينا تخلص من العرض، قبل أن يكون
+
+450
+00:29:34,900 --> 00:29:38,360
+التخلص لدينا تخلص من العرض، هذا ما يسمى تخلص من
+
+451
+00:29:38,360 --> 00:29:38,560
+العرض خلال
+
+452
+00:29:42,790 --> 00:29:46,730
+في وقت الانفجار، منذ وقت إصلاح الانفجار، إلى وقت
+
+453
+00:29:46,730 --> 00:29:51,390
+إيقاف المال، هذا مازل مبروك من الانفجار، أي مال
+
+454
+00:29:51,390 --> 00:29:57,890
+أكتر تجعله انفجار، يجب أن يتم إعلامه بالمؤسسات،
+
+455
+00:29:57,890 --> 00:30:04,850
+فهذا يعني أن الانفجار سيكون تحت حماية،
+
+456
+00:30:04,850 --> 00:30:10,240
+تحت حمايةكل الوقت اي مال اكتر تجعله يجب ان تعطيه
+
+457
+00:30:10,240 --> 00:30:14,960
+الى مؤسسة في أضافة لدراسة رقم 4 في الولايات
+
+458
+00:30:14,960 --> 00:30:21,900
+المتعاملة إذا كانت تعمل اي عملية عملية عملية عملية
+
+459
+00:30:21,900 --> 00:30:22,440
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+460
+00:30:22,440 --> 00:30:22,980
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+461
+00:30:22,980 --> 00:30:26,040
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+462
+00:30:26,040 --> 00:30:26,080
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+463
+00:30:26,080 --> 00:30:26,100
+عملية
+
+464
+00:30:37,260 --> 00:30:40,900
+هي حياة مختلفة، بداية جديدة، يمكن أن تكون مجاناً
+
+465
+00:30:40,900 --> 00:30:48,060
+رقم 4 كما قلت، يجب أن يتفرج، يتفرج نفسه كمال من
+
+466
+00:30:48,060 --> 00:30:52,460
+المال الذي أراد أن يستخدمه أو يريد أن يستخدمه كان
+
+467
+00:30:52,460 --> 00:30:57,860
+أكتر من 250 ريال. الأن بالإضافة إلى هذا، إذا كان
+
+468
+00:30:57,860 --> 00:31:01,670
+لديه حكومة بنكbuilding society in the UK they have
+
+469
+00:31:01,670 --> 00:31:05,130
+banks and they have building society building
+
+470
+00:31:05,130 --> 00:31:08,570
+society it means small banks they have small
+
+471
+00:31:08,570 --> 00:31:11,690
+financial institutes they call them building
+
+472
+00:31:11,690 --> 00:31:14,310
+society that's it's a term building society if
+
+473
+00:31:14,310 --> 00:31:17,630
+they have any account these will be closed the
+
+474
+00:31:17,630 --> 00:31:21,210
+accounts will be closed payments here he should
+
+475
+00:31:21,210 --> 00:31:23,690
+not make any direct payment to any of the
+
+476
+00:31:23,690 --> 00:31:31,070
+creditors all payments any extra money he makesبعد
+
+477
+00:31:31,070 --> 00:31:35,250
+ان يتخلص من المساعدة، يجب أن يتم إعطاء المساعدة
+
+478
+00:31:35,250 --> 00:31:39,870
+للمعارضة، وليس للمعارضة
+
+479
+00:31:41,930 --> 00:31:46,110
+يجب أن يقابل الحكومة في كل مرة يُطلب منه أن يقابل
+
+480
+00:31:46,110 --> 00:31:51,130
+الحكومة يجب أن يقابل الحكومة إذا لم يرفض سيكون
+
+481
+00:31:51,130 --> 00:31:53,870
+قابل الحكومة سيكون قابل الحكومة لذلك يجب أن يكون
+
+482
+00:31:53,870 --> 00:31:56,330
+صعب لمن ينظر إلى هذه النقطة هنا يجب أن يكون صعب
+
+483
+00:31:56,330 --> 00:32:01,270
+لشخص مثل هذا ليس شيء لتستمتع به كل شيء سيكون مقفل
+
+484
+00:32:01,270 --> 00:32:06,590
+في عملك ستكون مدعوة بكل المعلومات المالية و لن
+
+485
+00:32:06,590 --> 00:32:09,530
+تكون حرة حتى لتسجل في بعض الأحيان الناس لا
+
+486
+00:32:09,530 --> 00:32:12,580
+يستطيعون التسجلفي بعض الأحيان لن يتمكنوا من الخروج
+
+487
+00:32:12,580 --> 00:32:15,560
+من المنطقة التي يعيشون فيها. الكثير .. الكثير من
+
+488
+00:32:15,560 --> 00:32:19,300
+الانضمامات سيكون موضوع على الانفجار.
+
+489
+00:32:20,680 --> 00:32:25,120
+بالإضافة لدينا بعض المفاجأة. انظروا إلى المفاجأة.
+
+490
+00:32:25,320 --> 00:32:28,660
+إنها تبدو مثلها في بعض المناطق. المفاجأة في
+
+491
+00:32:28,660 --> 00:32:36,180
+الانفجار. رقم واحد، حنين.عندما يتم انفجار
+
+492
+00:32:36,180 --> 00:32:41,350
+الدكتورة، كل أساس الملائكة له يأتيIt's nothing
+
+493
+00:32:41,350 --> 00:32:45,870
+anyway including his home these are as you can see
+
+494
+00:32:45,870 --> 00:32:49,970
+disastrous long term implication for the long term
+
+495
+00:32:49,970 --> 00:32:53,630
+he will be poor all of or the rest of his life
+
+496
+00:32:53,630 --> 00:32:59,390
+most likely this bankrupt this bankrupt will be
+
+497
+00:32:59,390 --> 00:33:01,970
+poor for the rest of his life most likely because
+
+498
+00:33:01,970 --> 00:33:05,670
+any money he makes he have to be and he will not
+
+499
+00:33:05,670 --> 00:33:08,450
+be able to have the freedom to work in business
+
+500
+00:33:08,450 --> 00:33:16,010
+anymorenumber two جيدة restrictions placed upon
+
+501
+00:33:16,010 --> 00:33:19,790
+the bankrupt and the stigma of having to declare
+
+502
+00:33:19,790 --> 00:33:22,990
+oneself as a bankrupt for a certain transaction
+
+503
+00:33:22,990 --> 00:33:27,330
+it's a stigma once .. once you declareالاسم سيكون
+
+504
+00:33:27,330 --> 00:33:32,450
+في الكتابة، اسم الانفجار سيكون في الكتابة، كل شخص
+
+505
+00:33:32,450 --> 00:33:36,750
+في المجتمع سيعرف أن هذا المكان مغلق و هذا الرجل أو
+
+506
+00:33:36,750 --> 00:33:39,850
+هذه السيدة لا يعمل في الشركة بعد الأن لأنه أو انها
+
+507
+00:33:39,850 --> 00:33:46,030
+تصبح انفجار، لديه اهتمام نقلي ليس فقط عليه و حتى
+
+508
+00:33:46,030 --> 00:33:49,790
+في عائلته و أطفاله، هم لن يشعروا بإرادة شيء مثل
+
+509
+00:33:49,790 --> 00:33:53,510
+هذا، الناس سيشاهدونهمفي طريقة نجативة و حتى ان
+
+510
+00:33:53,510 --> 00:33:59,570
+تنظر في أوروبا الناس ستفكر انه بخير انه بخير اليوم
+
+511
+00:33:59,570 --> 00:34:02,970
+نخسر ربما في المستقبل نستطيع أن نصنع المال لهم شيء
+
+512
+00:34:02,970 --> 00:34:05,730
+يمكن أن يكون في بعض الأحيان طبيعي ولكن في مجتمعنا
+
+513
+00:34:05,730 --> 00:34:13,270
+الناس لن يقبله حتى اذا كان لديك قرار يمنحك الحرارة
+
+514
+00:34:13,270 --> 00:34:19,290
+و انت تعتقد ان الناس سيغفر عليكماذا تعتقد؟ بالطبع
+
+515
+00:34:19,290 --> 00:34:24,030
+انهم لن .. الناس هنا في مجتمعنا وحتى في أكتر دول
+
+516
+00:34:24,030 --> 00:34:29,670
+ثالث عالمين الناس الاستثناء لن يغفرون ويستمرون
+
+517
+00:34:29,670 --> 00:34:32,790
+بالطرح ان اذا لم يكونوا ناجحين في الحصول على المال
+
+518
+00:34:32,790 --> 00:34:37,090
+باستخدام نظام الحكومة يمكنهم الذهاب من نظام
+
+519
+00:34:37,090 --> 00:34:39,170
+التعامل التعامل التعامل التعامل التعامل التعامل
+
+520
+00:34:39,170 --> 00:34:40,130
+التعامل التعامل التعامل التعامل التعامل التعامل
+
+521
+00:34:40,130 --> 00:34:42,150
+التعامل التعامل التعامل التعامل التعامل التعامل
+
+522
+00:34:42,150 --> 00:34:42,330
+التعامل التعامل التعامل التعامل التعامل التعامل
+
+523
+00:34:42,330 --> 00:34:45,380
+التعامل التعامل التعامل التعامل التعامل التof
+
+524
+00:34:45,380 --> 00:34:50,300
+declaring somebody a bankrupt his business will be
+
+525
+00:34:50,300 --> 00:34:53,900
+immediately closed immediately it closed in
+
+526
+00:34:53,900 --> 00:34:56,920
+addition loss of any assets of value anything
+
+527
+00:34:56,920 --> 00:34:59,800
+which is important for you you might have the
+
+528
+00:34:59,800 --> 00:35:02,980
+house which you lived in for fifty years you might
+
+529
+00:35:02,980 --> 00:35:06,620
+lose it something you like so much like even
+
+530
+00:35:06,620 --> 00:35:08,740
+losing here the pension even the pension البنش
+
+531
+00:35:08,740 --> 00:35:13,600
+اللي هو التقاعدممكن تخسر حياتك، ممكن تخسر حياتك،
+
+532
+00:35:13,600 --> 00:35:17,800
+ممكن تخسر كل شيء لكي تدفع الناس الذين كنت من
+
+533
+00:35:17,800 --> 00:35:20,140
+المفروض أن تكون من البداية، وحتى هنا ممكن تخسر
+
+534
+00:35:20,140 --> 00:35:25,480
+الاناستيطانات اللي قد تحصل عليها في وقت الانتجار،
+
+535
+00:35:25,480 --> 00:35:30,640
+مثل انهيارات، في هذا الفرق، في عامين، عامين،
+
+536
+00:35:30,640 --> 00:35:33,600
+عامين، عامين، قبل أن يحاول هذا، هذا الشخص
+
+537
+00:35:33,600 --> 00:35:37,880
+الانتجاري أو الشخص الانتجاري، انهيارت مليون دولار
+
+538
+00:35:39,170 --> 00:35:43,390
+أبوه قد مات من هناك و انه قام باستخدامه و احصل على
+
+539
+00:35:43,390 --> 00:35:48,050
+مال جيد و هذا المال سيكون أخذ منه و سيكون أعطاه لـ
+
+540
+00:35:48,050 --> 00:35:52,890
+trustee و إذا حدث هذا .. إذا حدث هذا .. إذا حدث
+
+541
+00:35:52,890 --> 00:35:54,570
+هذا .. إذا حدث هذا .. إذا حدث هذا .. إذا حدث هذا
+
+542
+00:35:54,570 --> 00:35:56,790
+.. إذا حدث هذا .. إذا حدث هذا .. إذا حدث هذا ..
+
+543
+00:35:56,790 --> 00:36:04,830
+إذا حدث هذا .. إذا
+
+544
+00:36:04,830 --> 00:36:05,910
+حدث هذا
+
+545
+00:36:09,200 --> 00:36:13,160
+المقالات المالية ستبقى مغلقة هنا في أضافة إلى جميع
+
+546
+00:36:13,160 --> 00:36:23,220
+هذه النقطة مكانة ماهي مقانة؟ مكانة في مجتمع
+
+547
+00:36:23,220 --> 00:36:30,100
+التسلسل مكانته في السوق سيخسره في أضافة إلى
+
+548
+00:36:30,100 --> 00:36:34,280
+الانتجار لا يستطيع حتى أن ينظم شركة لا يستطيع أن
+
+549
+00:36:34,280 --> 00:36:36,520
+يعمل لأشخاص أخرين لتنظيمه يستطيع أن يعمل، نعم
+
+550
+00:36:36,520 --> 00:36:41,770
+المال يستطيع أن يعمليمكنه أن يكون موظف، لكنه لن
+
+551
+00:36:41,770 --> 00:36:45,070
+يكون قادر على الحصول على عمل في مجلس التعامل، لا
+
+552
+00:36:45,070 --> 00:36:47,030
+يمكنه أن يكون مدير، لا يمكنه أن يكون في مجلس
+
+553
+00:36:47,030 --> 00:36:50,810
+سينيوري، لا يمكنه أن يكون مالكتر، لا يمكنه أن يركض
+
+554
+00:36:50,810 --> 00:36:54,410
+في الحكومة، لا يمكنه أن يركض في الحكومة الموجودة،
+
+555
+00:36:54,410 --> 00:36:59,150
+ترى؟ كثير من الانقلابات، ليس بسهولة، كثير منها،
+
+556
+00:36:59,150 --> 00:37:03,180
+حتى القدرةفي البنك هو سيخسرها .. سيخسرها .. حتى
+
+557
+00:37:03,180 --> 00:37:04,980
+إذا كنت تريد أن تكون .. إذا كنت تريد أن تكون لديك
+
+558
+00:37:04,980 --> 00:37:08,440
+موقع بنك جديد ، يمكنك أن تكون له .. لكن هذا موقع
+
+559
+00:37:08,440 --> 00:37:12,480
+بنك جديد ، إذا كنت لديكه ، يجب أن تشرح للمعارضة
+
+560
+00:37:12,480 --> 00:37:16,200
+أنك لديك موقع بنك جديد ، و كم المال الذي لديك فيه
+
+561
+00:37:16,200 --> 00:37:19,200
+و كم المال الذي لديك خارج هذا الموقع بنك الجديد ،
+
+562
+00:37:19,200 --> 00:37:22,720
+إنه كثير مشكلة ، إنه ليس بسهولة لأشخاص يكونوا
+
+563
+00:37:22,720 --> 00:37:26,400
+يتمون من الانفصال ، هل تريد أن تقول شيء؟it was
+
+564
+00:37:26,400 --> 00:37:31,960
+live ولا بس after؟
+
+565
+00:37:34,950 --> 00:37:38,250
+بسبب أنه لا يمكن .. لا يمكن .. ليس متأكد ولكن لا
+
+566
+00:37:38,250 --> 00:37:42,270
+يمكن يعني إذا كان في مغامرة بالطبع لن يكون قادر
+
+567
+00:37:42,270 --> 00:37:49,250
+بعد أن يصبح .. بعد أن كان لديه فرصة فرصة لرحيل لكن
+
+568
+00:37:49,250 --> 00:37:52,730
+تعتقد أن هذا .. هذا سيكون بسيط له؟ تعتقد أن الناس
+
+569
+00:37:52,730 --> 00:37:55,810
+ستثق به؟ لرحيل لالاختيار؟
+
+570
+00:38:04,370 --> 00:38:10,450
+Do you have any alternatives to bankruptcy؟
+
+571
+00:38:10,450 --> 00:38:15,270
+bankruptcy is the worst situation، bankruptcy is
+
+572
+00:38:15,270 --> 00:38:18,410
+something that is not acceptable by many people،
+
+573
+00:38:18,410 --> 00:38:21,990
+but then we have to look for alternatives، one of
+
+574
+00:38:21,990 --> 00:38:28,480
+them is called informal arrangementوالدتر و الـ
+
+575
+00:38:28,480 --> 00:38:32,840
+creditors يمكنهم أن يجلسوا و يتكلمون عن الحقيقة و
+
+576
+00:38:32,840 --> 00:38:35,740
+يستطيعون أن يحلوها بأي معنى ممكن يستطيعوا أن
+
+577
+00:38:35,740 --> 00:38:36,460
+يتكلموا عن الحقيقة بأي معنى ممكن يستطيعوا أن
+
+578
+00:38:36,460 --> 00:38:36,860
+يتكلموا عن الحقيقة بأي معنى ممكن يستطيعوا أن
+
+579
+00:38:36,860 --> 00:38:37,880
+يتكلموا عن الحقيقة بأي معنى ممكن يستطيعوا أن
+
+580
+00:38:37,880 --> 00:38:38,980
+يتكلموا عن الحقيقة بأي معنى ممكن يستطيعوا أن
+
+581
+00:38:38,980 --> 00:38:41,640
+تتكلموا عن الحقيقة بأي معنى ممكن يستطيعوا أن
+
+582
+00:38:41,640 --> 00:38:44,820
+تتكلموا عن الحقيقة بأي معنى ممكن يستطيعوا أن
+
+583
+00:38:44,820 --> 00:38:50,500
+تتكلموا عن الحقيقة بأي معنى ممكن
+
+584
+00:38:50,500 --> 00:38:56,090
+يستطيعوا أن تتكلموا عن الحقيوهو حسنًا، أحد يستطيع
+
+585
+00:38:56,090 --> 00:38:59,890
+أن يجلس مع قدراته ويقوم بتحل المشكلة، والثاني هو
+
+586
+00:38:59,890 --> 00:39:03,150
+IVA، لقد كان لدينا ذلك قبل، ولكن علينا أن نشرحه في
+
+587
+00:39:03,150 --> 00:39:07,010
+التفاصيل الآن IVA، Individual Voluntary
+
+588
+00:39:07,010 --> 00:39:13,510
+Arrangement، هذا .. هذا .. أميليكا؟ هذا مجرد تحديث
+
+589
+00:39:13,510 --> 00:39:17,830
+قبلًا، مجرد تحديث قبلًا، المدير يحتاج إلى أن يطبق
+
+590
+00:39:17,830 --> 00:39:21,530
+.. يحتاج إلى أن يطبق على الشاطرة بمساعدة Anne
+
+591
+00:39:21,530 --> 00:39:25,710
+Eiffelheiminsolvency practitioner he or she would
+
+592
+00:39:25,710 --> 00:39:30,350
+supervise the arrangement and pay the creditor in
+
+593
+00:39:30,350 --> 00:39:35,030
+line with the accepted proposal okay as you said
+
+594
+00:39:35,030 --> 00:39:38,030
+before that we have this arrangement can be made
+
+595
+00:39:38,030 --> 00:39:41,730
+between can be made between between the trustee
+
+596
+00:39:41,730 --> 00:39:46,310
+which is called insolvency practitioner andالدتر
+
+597
+00:39:46,310 --> 00:39:49,890
+يمكن أن يكون لديه خطة و هذه الخطة هي اقتراح يمكن
+
+598
+00:39:49,890 --> 00:39:52,470
+أن يحتوي على التالي يمكن أن يحتوي بالطبع على كل
+
+599
+00:39:52,470 --> 00:39:55,490
+المعلومات الاجتماعية بالإضافة إلى اقتراح
+
+600
+00:39:55,490 --> 00:40:00,050
+للمستخدمين يمكن أن يكون مبني على اعطاء هذا اعطاء
+
+601
+00:40:00,050 --> 00:40:07,930
+سيكون مبني على 75% من المال اذا اتفق اذا اتفق
+
+602
+00:40:07,930 --> 00:40:13,530
+الدتروإذا كنا نحصل على قيمة 75% من المال ففي هذه
+
+603
+00:40:13,530 --> 00:40:17,330
+الحالة نحصل على إقبال أخير من القيمين ونستطيع أن
+
+604
+00:40:17,330 --> 00:40:20,730
+نأخذ هذه التفكيرة إلى الحكومة لإيقافها
+
+605
+00:40:22,350 --> 00:40:27,770
+الان كما ترى هنا قيمة المقالات 75% من قيمة
+
+606
+00:40:27,770 --> 00:40:34,410
+المقالات وليس 75% من المستخدمين حتى لو كان لديك 10
+
+607
+00:40:34,410 --> 00:40:39,790
+مستخدمين و 2 منهم فقط 2 منهم يمتلكون قيمة المقالات
+
+608
+00:40:39,790 --> 00:40:47,320
+75% وفي هذه الحالة يجب أن نفضلهميجب أن يقبلونه بأي
+
+609
+00:40:47,320 --> 00:40:51,640
+مدفع أولي أو ثانوي على مقالات محددة يجب أن ندفعهم
+
+610
+00:40:51,640 --> 00:40:53,840
+على مقالات محددة في فترة محددة من الوقت يمكن أن
+
+611
+00:40:53,840 --> 00:40:57,980
+يكونين عامين أو خمس عامين وفي هذا البرنامج إذا
+
+612
+00:40:57,980 --> 00:41:02,280
+اقبلوا هذا البرنامج يجب أن نأخذه إلى الحكومة
+
+613
+00:41:02,280 --> 00:41:05,800
+لإعطائه لإقبله لإعطائه لإعطائه لإعطائه لإعطائه
+
+614
+00:41:05,800 --> 00:41:07,980
+لإعطائه لإعطائه لإعطائه لإعطائه لإعطائه لإعطائه
+
+615
+00:41:07,980 --> 00:41:10,520
+لإعطائه لإعطائه لإعطائه لإعطائه لإعطائه لإعطائه
+
+616
+00:41:10,520 --> 00:41:12,180
+لإعطائه لإ
+
+617
+00:41:15,260 --> 00:41:19,480
+يجب أن يكون مدفع للمستخدمين لإيقافهم حتى يكون
+
+618
+00:41:19,480 --> 00:41:24,400
+لديهم مدفع أخر مدفع مدفع مدفع مدفع مدفع مدفع مدفع
+
+619
+00:41:24,400 --> 00:41:26,460
+مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع
+
+620
+00:41:26,460 --> 00:41:27,040
+مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع
+
+621
+00:41:27,040 --> 00:41:27,160
+مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع
+
+622
+00:41:27,160 --> 00:41:33,500
+مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع
+
+623
+00:41:33,500 --> 00:41:38,540
+م
+
+624
+00:41:41,360 --> 00:41:45,060
+و في هذه التخطيطة أو هذه التخطيطة انت تقبلها او لا
+
+625
+00:41:45,060 --> 00:41:48,660
+انت تقبلها لا احد يستطيع أن يجعل المستخدمين
+
+626
+00:41:48,660 --> 00:41:51,280
+يقبلوها انت مستخدمك انت مستخدمك انت مستخدمك انت
+
+627
+00:41:51,280 --> 00:41:52,840
+مستخدمك انت مستخدمك انت مستخدمك انت مستخدمك انت
+
+628
+00:41:52,840 --> 00:41:53,360
+مستخدمك انت مستخدمك انت مستخدمك انت مستخدمك انت
+
+629
+00:41:53,360 --> 00:41:53,720
+مستخدمك انت مستخدمك انت مستخدمك انت مستخدمك انت
+
+630
+00:41:53,720 --> 00:41:54,120
+مستخدمك انت مستخدمك انت مستخدمك انت مستخدمك انت
+
+631
+00:41:54,120 --> 00:42:00,980
+مستخدمك انت مستخدمك انت مستخدمك انت مستخدمك انت
+
+632
+00:42:00,980 --> 00:42:04,060
+مستخدمك
+
+633
+00:42:04,060 --> 00:42:10,860
+انت
+
+634
+00:42:10,860 --> 00:42:19,100
+مثالثًا ، لدينا حرارة إدارة. كما قلت إذا كانت
+
+635
+00:42:19,100 --> 00:42:24,220
+المالية أقل من 5000 ريال ، وهو قيمة صغيرة في هذه
+
+636
+00:42:24,220 --> 00:42:28,200
+الحالة، فلا يوجد نقطة لأن يكون هناك مغامرة. ليس
+
+637
+00:42:28,200 --> 00:42:31,440
+صحيح لك أن تكون هناك مغامرة. ثم لدينا قرار صنعه من
+
+638
+00:42:31,440 --> 00:42:37,060
+الحكومة بمعاملاتالدفع يجب أن يتم تحقيقه بالدفع إلى
+
+639
+00:42:37,060 --> 00:42:42,220
+الحكومة و المستخدم سيأتي لتحقيق دفعه من الحكومة
+
+640
+00:42:42,220 --> 00:42:44,920
+حتى يحصل انه يحصل انه يحصل انه يحصل انه يحصل انه
+
+641
+00:42:44,920 --> 00:42:45,260
+انه يحصل انه يحصل انه يحصل انه يحصل انه يحصل انه
+
+642
+00:42:45,260 --> 00:42:47,180
+يحصل انه يحصل انه يحصل انه يحصل انه يحصل انه يحصل
+
+643
+00:42:47,180 --> 00:42:49,400
+انه يحصل انه يحصل انه يحصل انه يحصل انه يحصل انه
+
+644
+00:42:49,400 --> 00:42:49,620
+يحصل انه يحصل انه يحصل انه يحصل انه يحصل انه يحصل
+
+645
+00:42:49,620 --> 00:42:57,480
+انه يحصل انه يحصل انه
+
+646
+00:42:59,230 --> 00:43:03,190
+الذي يجب أن يكون المال المطلوب من الحكومة التي
+
+647
+00:43:03,190 --> 00:43:09,370
+يمكن أن تكون حوالي 5000 فوائد وحتى
+
+648
+00:43:09,370 --> 00:43:14,570
+هذا المال 5 او 4 او ماذا ايه لا يوجد اهتمام انه او
+
+649
+00:43:14,570 --> 00:43:18,850
+انها لن يكون هناك اهتمام فوائد ولا اهتمام ولا
+
+650
+00:43:18,850 --> 00:43:21,150
+اهتمام ولا اهتمام ولا اهتمام ولا اهتمام ولا اهتمام
+
+651
+00:43:21,150 --> 00:43:21,190
+اهتمام ولا اهتمام ولا اهتمام ولا اهتمام ولا اهتمام
+
+652
+00:43:21,190 --> 00:43:21,690
+ولا اهتمام ولا اهتمام ولا اهتمام ولا اهتمام ولا
+
+653
+00:43:21,690 --> 00:43:22,390
+اهتمام ولا اهتمام ولا اهتمام ولا اهتمام ولا اهتمام
+
+654
+00:43:22,390 --> 00:43:26,510
+ولا اهتمام ولا اهتمام ولا اهتمام ولا اهتمام ولا
+
+655
+00:43:26,510 --> 00:43:30,710
+اههذه الأفعال يجب أن تتم إضافتها إلى المال التي
+
+656
+00:43:30,710 --> 00:43:38,530
+يجب أن تدفعه الدولة في وقت عام على مبادرة عامة كم
+
+657
+00:43:38,530 --> 00:43:42,830
+ساعة سيأخذ لكي تحصل على دستجراج؟ من تحرير الأسعار
+
+658
+00:43:42,830 --> 00:43:49,670
+إلى دستجراج كم ساعة سيأخذ؟ كم سنة؟ يمكن أن تأخذ
+
+659
+00:43:49,670 --> 00:43:52,730
+عامة واحد عامة كما قلت قبل في الولايات المتحدة
+
+660
+00:43:52,730 --> 00:43:58,820
+يمكن أن تأخذ عامة واحد عامةفي بعض الأحيان، هذا
+
+661
+00:43:58,820 --> 00:44:02,080
+الفرق أو هذا الوقت يمكن أن يتم استخدامه حتى 10
+
+662
+00:44:02,080 --> 00:44:06,940
+سنة، ربما أكتر أو أكتر، ببعض الأحيان، ببعض
+
+663
+00:44:06,940 --> 00:44:09,460
+الأحيان، كما يمكننا أن نرى هنا، هذا التجارب ليس
+
+664
+00:44:09,460 --> 00:44:13,280
+بالطبع اتماكي، ليس اتماكي يمكن أن يأخذ وقت، و يمكن
+
+665
+00:44:13,280 --> 00:44:16,800
+أن يأخذ هذا التجارب 1،2،3،4،5 سنة، يمكن أن يأخذ
+
+666
+00:44:16,800 --> 00:44:19,560
+وقت طويل، وحتى في بعض الأحيان، إذا كانوا يحصلوا
+
+667
+00:44:19,560 --> 00:44:23,960
+على هذا التجارب، يكون هناك بعض الخيارات مثل .. هل
+
+668
+00:44:23,960 --> 00:44:24,840
+تستطيع أن تقرأ؟
+
+669
+00:44:27,470 --> 00:44:28,350
+إن كان هناك مخاطر، إذا كان هناك مخاطر، إذا كان
+
+670
+00:44:28,350 --> 00:44:31,830
+هناك مخاطر، إذا كان هناك مخاطر, إذا كان هناك
+
+671
+00:44:31,830 --> 00:44:32,650
+مخاطر, إذا كان هناك مخاطر, إذا كان هناك مخاطر, إذا
+
+672
+00:44:32,650 --> 00:44:32,930
+مخاطر, إذا كان هناك مخاطر, إذا كان هناك مخاطر, إذا
+
+673
+00:44:32,930 --> 00:44:34,370
+كان هناك مخاطر, إذا كان هناك مخاطر, إذا كان هناك
+
+674
+00:44:34,370 --> 00:44:36,150
+مخاطر, إذا كان هناك مخاطر, إذا كان هناك مخاطر, إذا
+
+675
+00:44:36,150 --> 00:44:37,210
+كان هناك مخاطر, إذا كان هناك مخاطر, إذا كان هناك
+
+676
+00:44:37,210 --> 00:44:45,130
+مخاطر, إذا كان هناك مخاطر, إذا كان هناك
+
+677
+00:44:45,130 --> 00:44:49,810
+مخاطر, إذا كان هناوحتى لو كان لدينا اختيار لذلك
+
+678
+00:44:49,810 --> 00:44:53,790
+الشخص، فهناك اختيارات في الواقع انه او هي لن يكون
+
+679
+00:44:53,790 --> 00:44:57,070
+اختيار، لن يكون حر، يجب أن يكون مثل هذا، خاصة لو
+
+680
+00:44:57,070 --> 00:44:58,150
+كان لدينا عملية عملية عملية عملية عملية عملية
+
+681
+00:44:58,150 --> 00:45:01,810
+عملية عملية عملية عملية عملية
+
+682
+00:45:01,810 --> 00:45:01,950
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+683
+00:45:01,950 --> 00:45:02,270
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+684
+00:45:02,270 --> 00:45:02,770
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+685
+00:45:02,770 --> 00:45:05,710
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+686
+00:45:05,710 --> 00:45:11,850
+عملية عملية عملية عملية عملية عملية عملية عمل
+
+687
+00:45:12,300 --> 00:45:16,380
+لدينا اتفاق الثاني اذا لم يكن اتفاق الاول اتفاق
+
+688
+00:45:16,380 --> 00:45:18,040
+الثاني اذا لم يكن اتفاق الاول اتفاق الثاني اذا لم
+
+689
+00:45:18,040 --> 00:45:18,420
+يكن اتفاق الاول اتفاق الاول اتفاق الاول اتفاق
+
+690
+00:45:18,420 --> 00:45:20,960
+الاول اتفاق الاول اتفاق الاول اتفاق الاول اتفاق
+
+691
+00:45:20,960 --> 00:45:24,980
+الاول اتفاق الاول اتفاق الاول اتفاق الاول اتفاق
+
+692
+00:45:24,980 --> 00:45:25,660
+الاول اتفاق الاول اتفاق الاول اتفاق الاول اتفاق
+
+693
+00:45:25,660 --> 00:45:26,300
+الاول اتفاق الاول اتفاق الاول اتفاق الاول اتفاق
+
+694
+00:45:26,300 --> 00:45:34,260
+الاول اتفاق الاول اتفاق الاول اتفاق
+
+695
+00:45:34,260 --> 00:45:41,460
+الاول
+
+696
+00:45:41,460 --> 00:45:48,570
+اتفاوهذا الوقت يمكن أن يكون 8 أو 10 سنة إذا كان
+
+697
+00:45:48,570 --> 00:45:52,430
+يقوم بالخطاب إذا كان يخاطب الناس إذا كان يخاطب
+
+698
+00:45:52,430 --> 00:45:57,030
+الشرطة إذا لم يتعمل معها إذا كان المال كثير إذا
+
+699
+00:45:57,030 --> 00:46:00,090
+وإذا كان لديه الكثير من الأسباب التي يمكن أن يقرر
+
+700
+00:46:00,090 --> 00:46:06,050
+الشرطة أن تعطي هذا الشخص هذا الشرطة أو لا مرة
+
+701
+00:46:06,050 --> 00:46:09,670
+أخرى هذه ستجعلنا نفس المسألة التي كنت أقولها إذا
+
+702
+00:46:09,670 --> 00:46:17,880
+كان نفس الشخص مغامرمثلًا قبل هنا مثلًا هنا لدينا
+
+703
+00:46:17,880 --> 00:46:22,940
+تجارب و لدينا تجارب و بعد تجارب تجارب إذا كنت ترغب
+
+704
+00:46:22,940 --> 00:46:26,960
+أن تعود للعمل، يمكنك أن تكون لديك حياتك جديدة،
+
+705
+00:46:26,960 --> 00:46:30,160
+ولكن لديك بعض الانقلابات، لن تكون لديك الحرية،
+
+706
+00:46:30,160 --> 00:46:34,360
+ولكن عندما يمكنك أن تطبق هنا، يمكنك أن تطبق هنا،
+
+707
+00:46:34,360 --> 00:46:37,500
+لكي تكون مسموحًا لكي تعود لعمل، لعمل، يمكنك فعل
+
+708
+00:46:37,500 --> 00:46:41,310
+ذلكهذا يمكن ان يكون بعد 1 عام او 10 عام او 15 عام
+
+709
+00:46:41,310 --> 00:46:41,590
+او 15 عام او 15 عام او 15 عام او 15 عام او 15 عام
+
+710
+00:46:41,590 --> 00:46:41,990
+او 15 عام او 15 عام او 15 عام او 15 عام او 15 عام
+
+711
+00:46:41,990 --> 00:46:43,770
+او 15 عام او 15 عام او 15 عام او 15 عام او 15 عام
+
+712
+00:46:43,770 --> 00:46:45,750
+او 15 عام او 15 عام او 15 عام او 15 عام او 15 عام
+
+713
+00:46:45,750 --> 00:46:48,330
+او 15 عام او 15 عام او 15 عام او 15 عام او 15 عام
+
+714
+00:46:48,330 --> 00:46:48,390
+او 15 عام او 15 عام او 15 عام او 15 عام او 15 عام
+
+715
+00:46:48,390 --> 00:46:48,450
+او 15 عام او 15 عام او 15 عام او 15 عام او 15 عام
+
+716
+00:46:48,450 --> 00:46:54,570
+او 15 عام او 15 عام او 15 عام او 15 عام او 15 عام
+
+717
+00:46:54,570 --> 00:47:02,490
+او 15هو يصبح مغامرًا. المشكلة اللي نتعامل معها هنا
+
+718
+00:47:02,490 --> 00:47:08,170
+هي أنه لم يكن لديه مهمة بعد ذلك وانه ذهب للعمل
+
+719
+00:47:08,170 --> 00:47:13,170
+بدون إخبار المؤمنين وكان مغامرًا للثانوية مرة.
+
+720
+00:47:14,710 --> 00:47:18,990
+الاختلافات ستكون عظيمة. لربما لا يكون لديه مهمة في
+
+721
+00:47:18,990 --> 00:47:24,900
+المستقبل وربما يكون مجرمًاهو قد يكون في الحجز،
+
+722
+00:47:24,900 --> 00:47:29,480
+لدينا اتفاقات جديدة، آخر صفحة اللي لدينا هي، وهي
+
+723
+00:47:29,480 --> 00:47:34,520
+حقا مهمة، هل يمكن أن يكون التجارب عددها؟ هل نستطيع
+
+724
+00:47:34,520 --> 00:47:37,420
+أن نتخلص من التجارب؟ عندما يكون لدينا قرار مجرد
+
+725
+00:47:37,420 --> 00:47:44,120
+قرار مجرد قرار مجرد قرار مجرد قرار مجرد قرار مجرد
+
+726
+00:47:44,120 --> 00:47:44,540
+قرار مجرد قرار مجرد قرار مجرد قرار مجرد قرار مجرد
+
+727
+00:47:44,540 --> 00:47:44,580
+قرار مجرد قرار مجرد قرار مجرد قرار مجرد قرار مجرد
+
+728
+00:47:44,580 --> 00:47:48,060
+قرار مجرد قرار مجرد قرار مجرد
+
+729
+00:47:48,060 --> 00:47:52,700
+قرار م
+
+730
+00:47:53,270 --> 00:47:59,830
+هل نعيدها؟ نعم، كيف؟ لدينا ثلاثة أسلوب، كيف
+
+731
+00:47:59,830 --> 00:48:04,070
+نعيدها؟
+
+732
+00:48:04,070 --> 00:48:09,910
+الشخص
+
+733
+00:48:09,910 --> 00:48:11,810
+اللي يمكن أن يتعامل مع الشخص اللي يتعامل مع الشخص
+
+734
+00:48:11,810 --> 00:48:12,450
+اللي يتعامل مع الشخص اللي يتعامل مع الشخص اللي
+
+735
+00:48:12,450 --> 00:48:13,330
+يتعامل مع الشخص اللي يتعامل مع الشخص اللي يتعامل
+
+736
+00:48:13,330 --> 00:48:13,750
+مع الشخص اللي يتعامل مع الشخص اللي يتعامل مع الشخص
+
+737
+00:48:13,750 --> 00:48:15,870
+اللي يتعامل مع الشخص اللي يتعامل مع الشخص اللي
+
+738
+00:48:15,870 --> 00:48:15,930
+يتعامل مع الشخص اللي يتعامل مع الشخص اللي يتعامل
+
+739
+00:48:15,930 --> 00:48:16,430
+مع الشخص اللي يتعامل مع الشخص اللي يتعامل مع الشخص
+
+740
+00:48:16,430 --> 00:48:16,770
+اللي يتعامل مع
+
+741
+00:48:23,900 --> 00:48:29,780
+Okay number one if there was a mistake in the
+
+742
+00:48:29,780 --> 00:48:33,460
+proceduresإذا كان هناك خطأ كان هناك خطوات كانوا
+
+743
+00:48:33,460 --> 00:48:36,460
+يقومون بها خطوات خطوات كانوا يقومون بها خطوات
+
+744
+00:48:36,460 --> 00:48:39,460
+خطوات خطوات خطوات خطوات خطوات خطوات خطوات خطوات
+
+745
+00:48:39,460 --> 00:48:42,180
+خطوات خطوات خطوات خطوات خطوات خطوات خطوات خطوات
+
+746
+00:48:42,180 --> 00:48:42,260
+خطوات خطوات خطوات خطوات خطوات خطوات خطوات خطوات
+
+747
+00:48:42,260 --> 00:48:43,100
+خطوات خطوات خطوات خطوات خطوات خطوات خطوات خطوات
+
+748
+00:48:43,100 --> 00:48:47,140
+خطوات خطوات خطوات خطوات خطوات خ
+
+749
+00:49:00,230 --> 00:49:06,310
+إذا كانت المالكة قد قبلت كمية المال كمية كمية كمية
+
+750
+00:49:06,310 --> 00:49:07,050
+كمية كمية كمية كمية كمية كمية كمية كمية كمية كمية
+
+751
+00:49:07,050 --> 00:49:09,410
+كمية كمية كمية كمية كمية كمية كمية كمية كمية كمية
+
+752
+00:49:09,410 --> 00:49:13,610
+كمية كمية كمية كمية كمية كمية كمية كمية كمية كمية
+
+753
+00:49:13,610 --> 00:49:14,510
+كمية كمية كمية كمية كمية كمية كمية
+
+754
+00:49:27,520 --> 00:49:31,600
+بإمكاننا أن نتفاهم هنا بشكل صحيح بأن الانفجار
+
+755
+00:49:31,600 --> 00:49:35,580
+سيدفع الكثير من المال. نستطيع أن نتخلص من قرار
+
+756
+00:49:35,580 --> 00:49:40,040
+الانفجار ونستطيع أن نتحرك إلى شيء يسمى IVA، وهو
+
+757
+00:49:40,040 --> 00:49:47,340
+هنا في IVA، يجب أن يتم الانفجار قبل أن يكون هناك
+
+758
+00:49:47,340 --> 00:49:54,700
+انفجارعادةً الـ IVA هي مجلة ممنعية ممنعية ويقائية
+
+759
+00:49:54,700 --> 00:49:56,540
+هذه الانتجارة الانتجارية الانتجارية الانتجارية
+
+760
+00:49:56,540 --> 00:49:58,100
+الانتجارية الانتجارية الانتجارية الانتجارية
+
+761
+00:49:58,100 --> 00:50:01,360
+الانتجارية الانتجارية الانتجارية الانتجارية
+
+762
+00:50:01,360 --> 00:50:02,440
+الانتجارية الانتجارية الانتجارية الانتجارية
+
+763
+00:50:02,440 --> 00:50:02,820
+الانتجارية الانتجارية الانتجارية الانتجارية
+
+764
+00:50:02,820 --> 00:50:02,920
+الانتجارية الانتجارية الانتجارية الانتجارية
+
+765
+00:50:02,920 --> 00:50:05,680
+الانتجارية الانتجارية الانتجارية الانتجارية
+
+766
+00:50:05,680 --> 00:50:11,900
+الانتجارية الانتجارية الانتجارية الانتجارية
+
+767
+00:50:11,900 --> 00:50:12,720
+الانتجارية
+
+768
+00:50:15,680 --> 00:50:19,680
+الدترا قام و ال bankrupt قام و قال انا سأكون قيمة
+
+769
+00:50:19,680 --> 00:50:23,160
+المال انا لدي بعض المقارنات انا لدي بعض المشاركات
+
+770
+00:50:23,160 --> 00:50:27,400
+اعطيني بعض الوقت ثم نستطيع ان نطبق ال IV هذا يمكن
+
+771
+00:50:27,400 --> 00:50:29,600
+ان يكون قاسي يمكن ان يكون صعب يمكن ان يأخذ المزيد
+
+772
+00:50:29,600 --> 00:50:33,820
+من الوقت لأنه مصطلح بعد اتصال ال bankrupt لانه
+
+773
+00:50:33,820 --> 00:50:36,820
+يمكن ان يكون مشكلة جدا لان المال كذلك لقد أخذنا
+
+774
+00:50:36,820 --> 00:50:40,740
+المال منه و دفعناه بين الكثير من الناس الكثير من
+
+775
+00:50:40,740 --> 00:50:44,610
+المعارفينالان يجب أن ننظر مرة أخرى في نفس المقارنة
+
+776
+00:50:44,610 --> 00:50:48,030
+كم مال ندفعه كم يمكننا أن نعود كم يمكننا أن نعود
+
+777
+00:50:48,030 --> 00:50:48,710
+كم يمكننا أن نعود كم يمكننا أن نعود كم يمكننا أن
+
+778
+00:50:48,710 --> 00:50:49,690
+نعود كم يمكننا أن نعود كم يمكننا أن نعود كم يمكننا
+
+779
+00:50:49,690 --> 00:50:52,310
+أن نعود كم يمكننا أن نعود كم يمكننا أن نعود كم
+
+780
+00:50:52,310 --> 00:50:53,350
+يمكننا أن نعود كم يمكننا أن نعود كم يمكننا أن نعود
+
+781
+00:50:53,350 --> 00:50:55,790
+كم يمكننا أن نعود كم يمكننا أن نعود كم يمكننا أن
+
+782
+00:50:55,790 --> 00:50:56,350
+نعود كم يمكننا أن نعود كم يمكننا أن نعود كم يمكننا
+
+783
+00:50:56,350 --> 00:51:07,310
+أن نعود كم يمكننا أن نعود كم يمكننا أن نعود كم
+
+784
+00:51:07,310 --> 00:51:12,000
+يHello everybody, I want to talk mortgage business
+
+785
+00:51:12,000 --> 00:51:16,440
+.Mortgage contract is contract right to arrange my
+
+786
+00:51:16,440 --> 00:51:20,480
+eyes on something security for debt and trade law,
+
+787
+00:51:20,860 --> 00:51:23,900
+not as commercial mortgage contract as contract
+
+788
+00:51:23,900 --> 00:51:27,160
+right to arrange security for debt moved business.
+
+789
+00:51:27,820 --> 00:51:32,160
+هذا يعني أنه يوجد مرتجز مجتمع عن البروبيرتي التي
+
+790
+00:51:32,160 --> 00:51:36,760
+يجب أن تكون متحركة ويجب أن تجد دائما أن هناك حكومة
+
+791
+00:51:36,760 --> 00:51:43,400
+حقيقية تدفع بروبيرتي مع اتصال إلى طريق المال للدفع
+
+792
+00:51:43,400 --> 00:51:50,590
+للدفع والدفع يتم حفظه من بروبيرتيهذا التقرير مجتمع
+
+793
+00:51:50,590 --> 00:51:57,270
+مخصص، ولكنه أهم من ذلك هو ليس فقط فكرة تدفع حملة
+
+794
+00:51:57,270 --> 00:52:02,450
+حقيقية بطاقة استثمارية من نفس البروبرتي، ولكنه
+
+795
+00:52:02,450 --> 00:52:08,090
+مرتبط بالأمانات والشركات هي شركات تدفع حملة بطاقة
+
+796
+00:52:08,090 --> 00:52:14,050
+الشخصيةtransferring maybe material or moral but at
+
+797
+00:52:14,050 --> 00:52:18,090
+least that was the moral requirement to be
+
+798
+00:52:18,090 --> 00:52:22,670
+constant as negateable instruments so they can
+
+799
+00:52:22,670 --> 00:52:30,240
+reply to him that the mortgage businessوهو مقرر من
+
+800
+00:52:30,240 --> 00:52:38,480
+شركة موردجاش بلدجت دبت لدبتور عندما يكون موردجاش
+
+801
+00:52:38,480 --> 00:52:43,100
+مجتمع لدبتور ثم موردجاش مجتمع .. موردجاش مجتمع هو
+
+802
+00:52:43,100 --> 00:52:49,420
+خلق دبت مجتمع ثم عندما كان هناك دبت مجتمع وموردجاش
+
+803
+00:52:49,420 --> 00:52:54,320
+مجتمع قرر أن يكون موردجاش مجتمع بدون أنقص على شيء
+
+804
+00:52:54,320 --> 00:53:00,070
+آخرالتعامل الموردجيشي استمر بسبب أنه لا يمكن أن
+
+805
+00:53:00,070 --> 00:53:04,990
+يعمل موضوع مستقل يجب أن يكونوا مقررين أن يتأكدوا
+
+806
+00:53:04,990 --> 00:53:09,890
+أن الدين هو مصطلح الأطفال الأصليين مصطلح
+
+807
+00:53:09,890 --> 00:53:16,630
+الموردجيشي هو مصطلحه ومكانه هو التعامل الموردجيشي
+
+808
+00:53:16,630 --> 00:53:18,430
+بتعامل التعامل الموردجيشي بتعامل التعامل التعامل
+
+809
+00:53:18,430 --> 00:53:24,110
+الموردجيشي بتعامل التعامل الموردجيشيموردجاج مستخدم
+
+810
+00:53:24,110 --> 00:53:29,110
+لتحقيق موردجاجات موردجاجات مستخدم لتحقيق موردجاجات
+
+811
+00:53:29,110 --> 00:53:30,850
+مستخدم لتحقيق موردجاجات مستخدم لتحقيق موردجاجات
+
+812
+00:53:30,850 --> 00:53:32,110
+مستخدم لتحقيق موردجاجات مستخدم لتحقيق موردجاجات
+
+813
+00:53:32,110 --> 00:53:33,210
+مستخدم لتحقيق موردجاجات مستخدم لتحقيق موردجاجات
+
+814
+00:53:33,210 --> 00:53:33,430
+مستخدم لتحقيق موردجاجات مستخدم لتحقيق موردجاجات
+
+815
+00:53:33,430 --> 00:53:37,350
+مستخدم لتحقيق موردجاجات مستخدم لتحقيق موردجاجات
+
+816
+00:53:37,350 --> 00:53:44,330
+مستخدم لتحقيق موردجاجات
+
+817
+00:53:44,330 --> 00:53:47,670
+مستخدم لتحقيق موردجاجات مستخ
+
+818
+00:53:49,940 --> 00:53:58,580
+هو ربما للشخص الذاتي وشخص آخر يقدم، ونجد أيضًا أن
+
+819
+00:53:58,580 --> 00:54:06,140
+أكثر الشخص يمكن أن يأتي ويحمي الشيء، يقدم، وشخص
+
+820
+00:54:06,140 --> 00:54:14,900
+آخر يملك الشخصكيف تنتهي التقرير مورتغيش تقرر
+
+821
+00:54:14,900 --> 00:54:21,920
+بصراحة وإقبال لا يجب أن يكتب إنه لا يثبت أو يتجارب
+
+822
+00:54:21,920 --> 00:54:29,210
+في وجه الآخر هناك إختلافالاستثمار في مصالح الحقوق
+
+823
+00:54:29,210 --> 00:54:34,450
+اللازمة من المسلحين عندما المسلحين يدفعوا نقطة أو
+
+824
+00:54:34,450 --> 00:54:39,070
+مسلحين أخرى للتعامل مع بعضهم بمجال التعامل مع
+
+825
+00:54:39,070 --> 00:54:40,930
+بعضهم بمجال التعامل مع بعضهم بمجال التعامل مع
+
+826
+00:54:40,930 --> 00:54:42,090
+بعضهم بمجال التعامل مع بعضهم بمجال التعامل مع
+
+827
+00:54:42,090 --> 00:54:43,270
+بعضهم بمجل التعامل مع بعضهم بمجل التعامل مع بعضهم
+
+828
+00:54:43,270 --> 00:54:44,250
+بمجل التتعامل مع بعضهم بمجل التتعامل مع بعضهم بمجل
+
+829
+00:54:44,250 --> 00:54:45,490
+التتعامل مع بعضهم بمجل التتعامل مع بعضهم بمجل
+
+830
+00:54:45,490 --> 00:54:49,710
+التتععندما يكون المعاملة مقررة في المسلحة لتكون
+
+831
+00:54:49,710 --> 00:54:57,250
+شكل مدرسة في حالة المسلحة ولكن إذا كانت اسمها يجب
+
+832
+00:54:57,250 --> 00:55:02,350
+أن تكون مدير ويأخذ حركة، وهو عادة مستقبل في كتب
+
+833
+00:55:02,350 --> 00:55:07,970
+المسلحة التي تم إتجارها، يكونوا مضطرين إلى المسلحة
+
+834
+00:55:07,970 --> 00:55:10,250
+التي يتم إتجارها في المسلحة التي يتم إتجارها في
+
+835
+00:55:10,250 --> 00:55:11,050
+المسلحة التي يتم إتجارها في المسلحة التي يتم
+
+836
+00:55:11,050 --> 00:55:13,510
+إتجارها في المسلحة التي يتم إتجارها في المسلحة
+
+837
+00:55:13,510 --> 00:55:15,150
+التي يتم إتجارها في المسلحة التي يتم إتجارها في
+
+838
+00:55:15,150 --> 00:55:15,390
+المسلحة التي يتم إتجارها في المسلحة التي يتم إتج
+
+839
+00:55:16,780 --> 00:55:21,320
+ماهي اهتمام الـ Mortgage؟ الـ Resulting Mortgage
+
+840
+00:55:21,320 --> 00:55:25,860
+possesory two rights. One right in solitary thing.
+
+841
+00:55:26,260 --> 00:55:30,960
+B right of proprietary in obtaining the loan
+
+842
+00:55:30,960 --> 00:55:34,540
+amount and recovery of the price of the mortgaged
+
+843
+00:55:34,540 --> 00:55:40,770
+and legislature.بالنسبة لهذه الاثنين الأفكار قالوا
+
+844
+00:55:40,770 --> 00:55:46,110
+إنهم لا يتجاربوا نفسهم في الجزء الثالث إلا إذا
+
+845
+00:55:46,110 --> 00:55:52,710
+كانت التغيير من بوثشان إلى موردجاجي وليس فقط كذلك،
+
+846
+00:55:52,710 --> 00:55:57,810
+ولكن ما كان موردجاجي في بوثشان من موردجاجي هو طول
+
+847
+00:55:57,810 --> 00:56:04,010
+الموردجاجon the transfer of position. position the
+
+848
+00:56:04,010 --> 00:56:07,790
+character and mortgage is the number of images
+
+849
+00:56:10,980 --> 00:56:16,480
+وانتقل إلى موقف الحقيقي وانتقل إلى موقف الوطن الذي
+
+850
+00:56:16,480 --> 00:56:21,660
+يتطلب استخدام المساعدة أو
+
+851
+00:56:21,660 --> 00:56:26,860
+فقط تأخذ موقف الوطن الذي يتطلب استخدام المساعدة
+
+852
+00:56:26,860 --> 00:56:30,180
+وانتقل إلى موقف الوطن الذي يتطلب استخدام المساعدة
+
+853
+00:56:30,180 --> 00:56:30,640
+أو انتقل إلى موقف الوطن اللي يتطلب استخدام
+
+854
+00:56:30,640 --> 00:56:32,820
+المساعدة أو انتقل إلى موقف الوطن اللي يتطلب
+
+855
+00:56:32,820 --> 00:56:34,380
+استخدام المساعدة أو انتقل إلى موقف الوطن اللي
+
+856
+00:56:34,380 --> 00:56:36,160
+يتطلب استخدام المساعدة أو انتقل إلى موقف الوطن
+
+857
+00:56:36,160 --> 00:56:39,560
+اللي يتطلب استخدام المساعدة أو انتقل إلى موقف
+
+858
+00:56:39,560 --> 00:56:39,600
+الوطن اللي يتط
+
+859
+00:57:01,390 --> 00:57:04,530
+وهو تحويل المصادر
+
+860
+00:57:06,940 --> 00:57:13,320
+إذا كانت الشيء الصحيح أن يتحرر أو يتخلص، كانت
+
+861
+00:57:13,320 --> 00:57:16,880
+الشيء الصحيح أن يتحرر أو يتخلص، كانت حق الكريدور
+
+862
+00:57:16,880 --> 00:57:22,600
+أن يطلب من الشيطان أن يقوم بتفصيلها، وكذلك، الشيء
+
+863
+00:57:22,600 --> 00:57:27,980
+سيدخل في حركة الكريدور، ويخلق على رأسه عمليات
+
+864
+00:57:27,980 --> 00:57:31,860
+عديدة، وعندما كان الشيطان يحرر الشيطان، وعندما
+
+865
+00:57:31,860 --> 00:57:37,310
+يحصل على الشيطان،استخدام مصطلح الموردجيش مصطلح
+
+866
+00:57:37,310 --> 00:57:41,810
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+867
+00:57:41,810 --> 00:57:47,470
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+868
+00:57:47,470 --> 00:57:47,590
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+869
+00:57:47,590 --> 00:57:47,670
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+870
+00:57:47,670 --> 00:57:53,050
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+871
+00:57:53,050 --> 00:57:57,510
+مصط
+
+872
+00:57:59,170 --> 00:58:03,430
+حسنًا، سنتحدث عن جزء صحيح من الـ e-commerce قبل
+
+873
+00:58:03,430 --> 00:58:08,470
+ذلك، سنسأل أسئلة واحدة وهي، هل مجتمع الإنترنت ممكن
+
+874
+00:58:08,470 --> 00:58:14,710
+تحميله؟ في عملياتنا، نحصل عادة على أسئلة عن ممكنة
+
+875
+00:58:14,710 --> 00:58:21,610
+تحميل مجتمع الإنترنت ممكن تحميل مجتمع الإنترنت
+
+876
+00:58:21,610 --> 00:58:22,550
+ممكن تحميل مجتمع الإنترنت ممكن تحميل مجتمع
+
+877
+00:58:22,550 --> 00:58:24,670
+الإنترنت ممكن تحميل مجتمع الإنترنت ممكن تحميل
+
+878
+00:58:24,670 --> 00:58:26,930
+مجتمع الإنترنت ممكن تحميل مجتمع الإنترنت ممكن
+
+879
+00:58:26,930 --> 00:58:27,090
+تحميل مجتمع الإنترنت ممكن تحميل مجتمع الإنترنت
+
+880
+00:58:27,090 --> 00:58:28,750
+ممكن تحميل مجتمع الإنترنت ممكنأما إذا كانت
+
+881
+00:58:28,750 --> 00:58:32,230
+المشاركة تتم تصميمها من جمهور الشركات على الإنترنت
+
+882
+00:58:32,230 --> 00:58:39,170
+أو من إجراء مقالات مكتوبة على الإنترنت أو
+
+883
+00:58:39,170 --> 00:58:39,510
+على الإنترنت أو على الإنترنت أو على الإنترنت أو
+
+884
+00:58:39,510 --> 00:58:39,610
+على الإنترنت أو على الإنترنت أو على الإنترنت أو
+
+885
+00:58:39,610 --> 00:58:39,970
+على الإنترنت أو على الإنترنت أو على الإنترنت أو
+
+886
+00:58:39,970 --> 00:58:41,130
+على الإنترنت أو على الإنترنت أو على الإنترنت أو
+
+887
+00:58:41,130 --> 00:58:44,330
+على الإنترنت أو على الإنترنت أو على الإنترنت أو
+
+888
+00:58:44,330 --> 00:58:45,490
+على الإنترنت أو على الإنترنت أو على الإنترنت أو
+
+889
+00:58:45,490 --> 00:58:46,730
+على الإنترнет أو على الإنترнет أو على الإنترнет أو
+
+890
+00:58:46,730 --> 00:58:49,490
+على الإنترнет أو على الإنترнет أو على الإنترнет أو
+
+891
+00:58:49,490 --> 00:58:52,550
+على الإنترнет أو على الإينتUnderstanding
+
+892
+00:58:52,550 --> 00:58:57,490
+Electronic Data Interchange Building and Managing
+
+893
+00:58:57,490 --> 00:59:01,090
+a Virtual Team Product Development Developing Your
+
+894
+00:59:01,090 --> 00:59:04,950
+Online Store Online Transactions Etc Online
+
+895
+00:59:04,950 --> 00:59:07,730
+Marketing and Monitoring Your Websites and Other
+
+896
+00:59:07,730 --> 00:59:12,620
+General Resourcesالثانية E-Commerce وقانونها E
+
+897
+00:59:12,620 --> 00:59:15,380
+-Commerce وقانونها E-Commerce وقانونها E-Commerce
+
+898
+00:59:15,380 --> 00:59:20,860
+وقانونها E-Commerce وقانونها E-Commerce وقانونها E
+
+899
+00:59:20,860 --> 00:59:23,120
+-Commerce وقانونها E-Commerce وقانونها E-Commerce
+
+900
+00:59:23,120 --> 00:59:26,940
+وقانونها E-Commerce وقانونها E-Commerce وقانونها E
+
+901
+00:59:26,940 --> 00:59:28,420
+-Commerce وقانونها E-Commerce وقانونها E-Commerce
+
+902
+00:59:28,420 --> 00:59:30,200
+وقانونها E-Commerce وقانونها E-Commerce وقانونها E
+
+903
+00:59:30,200 --> 00:59:31,560
+-Commerce وقانونها E-Commerce وقانونها E-Commerce
+
+904
+00:59:31,560 --> 00:59:37,160
+وقانونها E
+
+905
+00:59:37,160 --> 00:59:43,080
+-CommerceA commerce and tax law journal, a legal
+
+906
+00:59:43,080 --> 00:59:45,260
+publication recreated and published by the
+
+907
+00:59:45,260 --> 00:59:48,800
+internet business law services ILBS, the world's
+
+908
+00:59:48,800 --> 00:59:52,220
+largest interest law publisher and Thomas
+
+909
+00:59:52,220 --> 00:59:56,120
+Jefferson school of law master's in law program,
+
+910
+00:59:56,680 --> 01:00:00,440
+the law journal published writing by academics
+
+911
+01:00:03,110 --> 01:00:06,990
+التعاملين والمصادر على مجموعة من المواضيع بما
+
+912
+01:00:06,990 --> 01:00:08,990
+يتعلق بـ E-Commerce Electronic Contracting
+
+913
+01:00:08,990 --> 01:00:13,570
+Technotorts Cybercrime Privacy Internet Taxation
+
+914
+01:00:13,570 --> 01:00:16,790
+International Taxation وكذلك التعامل الإلكتروني
+
+915
+01:00:16,790 --> 01:00:22,110
+الانترنتي الانترنتي
+
+916
+01:00:22,110 --> 01:00:26,030
+الانترنتي الانترنتي الانترنتيمجلد يتطور ويقوم
+
+917
+01:00:26,030 --> 01:00:29,910
+بإنجاز أسهل ومساعدة ومساعدة ومساعدة ومساعدة
+
+918
+01:00:29,910 --> 01:00:30,750
+ومساعدة ومساعدة ومساعدة ومساعدة ومساعدة ومساعدة
+
+919
+01:00:30,750 --> 01:00:34,110
+ومساعدة ومساعدة ومساعدة ومساعدة ومساعدة ومساعدة
+
+920
+01:00:34,110 --> 01:00:34,450
+ومساعدة ومساعدة ومساعدة ومساعدة ومساعدة ومساعدة
+
+921
+01:00:34,450 --> 01:00:35,230
+ومساعدة ومساعدة ومساعدة ومساعدة ومساعدة ومساعدة
+
+922
+01:00:35,230 --> 01:00:44,010
+ومساعدة ومساعدة ومساعدة ومساعدة ومساعدة
+
+923
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+ومساعد
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+
+925
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+الإلكترونية ومجموعة العمل على التدخل في المصادر
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+926
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+الإلكترونية ومجموعة العمل على التدخل في المصادر
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+927
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+الإلكترونية ومجموعة العمل على التدخل في المصادر
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+928
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+الإلكترونية ومجموعة العمل على التدخل في المصادر
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+929
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+الإلكترونية ومجموعة العمل على التدخل في المصادر
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+930
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+الإلكترونية ومجموعة العمل على التدخل في المصادر
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+931
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+الإلكترونية ومجموعة العمل على التدخل في المصادر
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+932
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+الإلكترونية ومجموعة العمل على التدخل في المصادر
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+933
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+934
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+تسيطر على المشاركات الإجتماعية الإجتماعية، يتضمن
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+935
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+939
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+الخدمة الإلكترونية الولايات المتحدة على القانون
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+مجلدًا مجلدًا مجلدًا مجلدًا مجلدًا مجلدًا مجلدًا
+
+945
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+مجلدًا مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد
+
+946
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+مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد
+
+947
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+مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد
+
+948
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+مجلد مجل
+
diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/nMUc4Kth5Ys_raw.json b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/nMUc4Kth5Ys_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..0e91f5edb656ad52c2fb7256e27af9b3fcb7ed99
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/nMUc4Kth5Ys_raw.json
@@ -0,0 +1 @@
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\ No newline at end of file
diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/nMUc4Kth5Ys_raw.srt b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/nMUc4Kth5Ys_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..06ef6564e4f3c19d178299ab8ea378f74abee231
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/nMUc4Kth5Ys_raw.srt
@@ -0,0 +1,3896 @@
+1
+00:00:11,600 --> 00:00:16,820
+Okay السلام عليكم I hope this would be the last
+
+2
+00:00:16,820 --> 00:00:21,930
+lecture in bankruptcyand next week we have to
+
+3
+00:00:21,930 --> 00:00:24,030
+finalize all what we have and we can speak about
+
+4
+00:00:24,030 --> 00:00:28,710
+the exam but for now we have 10 slides to finish
+
+5
+00:00:28,710 --> 00:00:34,750
+or 11 slides in bankruptcy and we still talking
+
+6
+00:00:34,750 --> 00:00:37,170
+about bankruptcy in the UK, we finish with
+
+7
+00:00:37,170 --> 00:00:40,250
+bankruptcy in the USA and the general meaning and
+
+8
+00:00:40,250 --> 00:00:43,560
+concept of bankruptcyولكن اليوم بانكروبسيا في
+
+9
+00:00:43,560 --> 00:00:46,020
+الولايات المتحدة قلنا .. في الولايات المتحدة قلنا
+
+10
+00:00:46,020 --> 00:00:50,240
+إنها مخصصة، أحد يمكن أن يقبل لبنكروبسيا، فيما فيه
+
+11
+00:00:50,240 --> 00:00:53,380
+أنه أو أنها تشعر أنهم لا يمكنوا أن يدفعوا المال
+
+12
+00:00:53,380 --> 00:00:57,560
+لهم، فهم لا يمكنوا أن يقبلوا لبنكروبسيا، واحد من
+
+13
+00:00:57,560 --> 00:01:00,920
+الأسئلة التي يمكن أن يكون طرحها هنا هو عندما وكيف؟
+
+14
+00:01:01,640 --> 00:01:04,940
+لقد تحدثنا في السابق عن عندما نستطيع أن نطلع من
+
+15
+00:01:04,940 --> 00:01:09,780
+الانتجار في الواقع إن كان شخص ما في حاجة هناك مال
+
+16
+00:01:09,780 --> 00:01:12,580
+لم يكن قادر على التدفع و هذه الشخصية لم تستطيع أن
+
+17
+00:01:12,580 --> 00:01:18,780
+تدفعهم الآن قلنا أيضًا أننا يجب أن نستخدم المطالب
+
+18
+00:01:18,780 --> 00:01:22,560
+الذي يسمى مطالب الانتجار ولكن هذا المطالب الانتجار
+
+19
+00:01:22,560 --> 00:01:27,840
+يجب أن يتم إرساله إلى الحكومة إذا كان الحكومة في
+
+20
+00:01:27,840 --> 00:01:31,670
+الولايات المتحدةبإمكاننا أن نرسل مطالب الانفجار أو
+
+21
+00:01:31,670 --> 00:01:35,830
+ملف الانفجار يجب أن يتم إرساله إلى القاضية الخاصة
+
+22
+00:01:35,830 --> 00:01:39,890
+التي يمكن أن تكون القاضية العالية في لندن ويمكن أن
+
+23
+00:01:39,890 --> 00:01:45,630
+تكون القاضية المدينة في بلستان لدينا نفس الوضع يجب
+
+24
+00:01:45,630 --> 00:01:49,190
+أن نرسل مطالب الانفجار إلى القاضية المناسبة يمكن
+
+25
+00:01:49,190 --> 00:01:51,150
+أن يكون في مدينة غزا ويمكن أن يكون في نابلوس ويمكن
+
+26
+00:01:51,150 --> 00:01:56,970
+أن يكون في مكان آخر هذا يعتمد على المكان
+
+27
+00:01:58,340 --> 00:02:01,960
+of the data where he used to live if he was living
+
+28
+00:02:01,960 --> 00:02:04,940
+in Gaza city then we have to submit the file to
+
+29
+00:02:04,940 --> 00:02:08,520
+the Gaza city court if he was living in London we
+
+30
+00:02:08,520 --> 00:02:11,300
+have to send it to the high court of London or
+
+31
+00:02:11,300 --> 00:02:15,520
+county court near the place he used to live
+
+32
+00:02:15,520 --> 00:02:18,300
+location we look because we're not going to look
+
+33
+00:02:18,300 --> 00:02:21,120
+at the place where the creditors live we look at
+
+34
+00:02:21,120 --> 00:02:23,220
+the place where the debtor lives location the
+
+35
+00:02:23,220 --> 00:02:28,620
+house where he normally livesإذا لم يكن في البلد و
+
+36
+00:02:28,620 --> 00:02:34,580
+أحيانًا يحدث أن بعض الناس لديهم عمل أفضل و في وقت
+
+37
+00:02:34,580 --> 00:02:39,340
+الانفجار يهربوا و يغادروا البلد فإذا لم يكن موجود
+
+38
+00:02:39,340 --> 00:02:43,500
+في البلد إذا لم يكن يعيش هنا بعد الان يجب أن ننظر
+
+39
+00:02:43,500 --> 00:02:47,060
+في الماضي إلى المكان الذي كان يعيش فيه في الماضي
+
+40
+00:02:47,060 --> 00:02:50,860
+إذا كان يعيش في مدينة غزا فيجب أن نرسل رسالة
+
+41
+00:02:50,860 --> 00:02:52,660
+لإخباره
+
+42
+00:02:54,690 --> 00:02:59,230
+مقالات الانفجار يتم تحقيقها في الحكومة يجب أن نرسل
+
+43
+00:02:59,230 --> 00:03:04,310
+الوثيقة إلى المكان الذي كان يعيش فيه أو نستطيع أن
+
+44
+00:03:04,310 --> 00:03:07,770
+نرسله حتى نستطيع أن نرسله إلى المكان الذي كان يعيش
+
+45
+00:03:07,770 --> 00:03:11,930
+فيه لديه شركة اتصال شركة اتصال اللي كان يعيش فيه
+
+46
+00:03:11,930 --> 00:03:14,970
+لديه اتصال اذا كنت تريد أن تكون لديك شيء مثل هذا
+
+47
+00:03:14,970 --> 00:03:19,450
+تطلب الانفجار و أنت تفهم بالضبط ما يجب أن تفعله و
+
+48
+00:03:19,450 --> 00:03:22,410
+كيف ستفعله و في أي الحكومة التي يجب أن ترسل
+
+49
+00:03:22,410 --> 00:03:26,300
+الوثيقةو هناك بعض الوصفات و بعض المحللين اللي
+
+50
+00:03:26,300 --> 00:03:30,960
+يخبرك عن هذه الحالة بطريقة ما هناك وصفة هنا في
+
+51
+00:03:30,960 --> 00:03:33,560
+الولايات المتحدة فقط و في هذه الوصفة يمكنك أن تنظر
+
+52
+00:03:33,560 --> 00:03:37,680
+و تجد كيف يمكنك أن تشرح مصالح الانتجار أو مصالح
+
+53
+00:03:37,680 --> 00:03:43,800
+الانتجار لحكم محدد و بعد أن نشرح مصالح الانتجار
+
+54
+00:03:43,800 --> 00:03:47,280
+اللي يسمى مصالح الانتجار او مصالح الانتجار
+
+55
+00:03:47,280 --> 00:03:50,740
+فالحكومة ستقرر
+
+56
+00:03:52,470 --> 00:03:58,010
+هل يمكن تحقق تطبيق هذه التطبيقات من هذا الحكومة أو
+
+57
+00:03:58,010 --> 00:04:00,610
+لا؟ إذا كانت هذه الحكومة المناسبة، إذا كانت هذه
+
+58
+00:04:00,610 --> 00:04:04,770
+الحكومة لديها حكومة لتحقق حكومة المغامرة أو لا؟
+
+59
+00:04:04,770 --> 00:04:08,130
+إذا لم يكن، فهذا الفيديو يتم إرساله إلى الحكومة
+
+60
+00:04:08,130 --> 00:04:15,270
+المحددةإذا اكتشفت الحكومة في مدينة غزا أن الدكتور
+
+61
+00:04:15,270 --> 00:04:18,910
+كان يعيش في خان يونيس، فسيُرحل الملف كام لحكومة
+
+62
+00:04:18,910 --> 00:04:24,910
+خان يونيس. لذلك ننظر إلى حكومة الحكومة إذا كانت
+
+63
+00:04:24,910 --> 00:04:29,550
+ممكنة أن ننظر إلى حكومة الانقلاب أو لا. ثم في
+
+64
+00:04:29,550 --> 00:04:33,490
+المرحلة التالية، يجب أن نرى ما يحدث في الحكومة.
+
+65
+00:04:34,070 --> 00:04:41,460
+إذا قرر الحكومة أن حكومة حكومتها ومنطقةهاو يستطيع
+
+66
+00:04:41,460 --> 00:04:46,880
+أن ينظر إلى هذه التطبيقات ثم في السجن سنرى الآن
+
+67
+00:04:46,880 --> 00:04:52,900
+ماذا سيحدث ماذا تظن يمكن أن يحدث في السجن تخيل
+
+68
+00:04:52,900 --> 00:04:58,760
+أننا اليوم لدينا صفحة بانكرابسي صفحة بانكرابسي و
+
+69
+00:04:58,760 --> 00:05:04,500
+هذا الصفحة نرسله للسجن وكانت في مدينة غزا وكانت
+
+70
+00:05:04,500 --> 00:05:09,780
+مرة أخرى إسحانين كانت الشخص اللي نريده أن يكون
+
+71
+00:05:09,780 --> 00:05:18,900
+بانكرابتعن حالتك في مجال التجارب في مدينة غزا
+
+72
+00:05:18,900 --> 00:05:25,340
+هنا لدينا أحد أربع من أربع من الممكن أن يكون هناك
+
+73
+00:05:25,340 --> 00:05:31,400
+حلول ممكن أن يكون هناك حلول واحد من أربع ممكن أن
+
+74
+00:05:31,400 --> 00:05:34,400
+يكون هناك حلولإذا كانت أنت، ماذا يمكنك أن تفعل؟
+
+75
+00:05:34,400 --> 00:05:38,100
+اليوم لديك حالة مثل هذه أمامك التي تسمى بانكروبسي
+
+76
+00:05:38,100 --> 00:05:41,760
+ويجب أن تنظر إليها، ماذا يمكنك أن تفعل؟ هل يمكنك
+
+77
+00:05:41,760 --> 00:05:45,460
+أن تأخذ قرار من المجلس الأول؟ هل يمكنك أن تعلن عن
+
+78
+00:05:45,460 --> 00:05:48,040
+بانكروبسي؟ هل يمكنك أن تحصل على حرارة بانكروبسي؟
+
+79
+00:05:48,040 --> 00:05:52,720
+حرارة بانكروبسي هي القرار اللي تم إصلاحه القاضي
+
+80
+00:05:52,720 --> 00:05:58,400
+وهذه القرارة يعني أن هذا الشخص، المدفع يصبح مفلس
+
+81
+00:05:58,400 --> 00:06:03,050
+بانكروبسوهو يصبح مغامر على هذا الوقت، وكان مجرد
+
+82
+00:06:03,050 --> 00:06:06,790
+مغامر مجرد مجرد قرار مجرد قرار مجرد قرار مجرد قرار
+
+83
+00:06:06,790 --> 00:06:09,910
+مجرد قرار
+
+84
+00:06:09,910 --> 00:06:17,110
+مجرد قرار مجرد قرار مجرد قرار مجرد قرار مجرد قرار
+
+85
+00:06:17,110 --> 00:06:18,950
+مجرد قرار مجرد قرار مجرد قرار مجرد قرار مجرد قرار
+
+86
+00:06:18,950 --> 00:06:18,950
+مجرد قرار مجرد قرار مجرد قرار مجرد قرار مجرد قرار
+
+87
+00:06:18,950 --> 00:06:20,090
+مجرد قرار مجرد قرار مجرد قرار مجرد قرار مجرد قرار
+
+88
+00:06:20,090 --> 00:06:34,610
+مجرد قرار مجرد قرار مجرد قchance for what؟
+
+89
+00:06:34,610 --> 00:06:38,990
+we considering the whole case for more research
+
+90
+00:06:38,990 --> 00:06:44,190
+and more inspecting of the whole case؟ if you look
+
+91
+00:06:44,190 --> 00:06:47,630
+in Gaza for example here we have the courts most
+
+92
+00:06:47,630 --> 00:06:54,420
+likely they would delayوانتظر هناك وانتظر هناك
+
+93
+00:06:54,420 --> 00:06:58,620
+وانتظر هناك
+
+94
+00:06:58,620 --> 00:07:02,880
+وانتظر هناك وانتظر هناك وانتظر هناك وانتظر هناك
+
+95
+00:07:02,880 --> 00:07:03,580
+وانتظر هناك وانتظر هناك وانتظر هناك وانتظر هناك
+
+96
+00:07:03,580 --> 00:07:03,580
+وانتظر هناك وانتظر هناك وانتظر هناك وانتظر هناك
+
+97
+00:07:03,580 --> 00:07:03,640
+وانتظر هناك وانتظر هناك وانتظر هناك وانتظر هناك
+
+98
+00:07:03,640 --> 00:07:03,720
+وانتظر هناك وانتظر هناك وانتظر هناك وانتظر هناك
+
+99
+00:07:03,720 --> 00:07:04,360
+وانتظر هناك وانتظر هناك وانتظر هناك وانتظر هناك
+
+100
+00:07:04,360 --> 00:07:05,920
+وانتظر هناك وانتظر هناك وانتظر هناك وانتظر هناك
+
+101
+00:07:05,920 --> 00:07:08,760
+وانتظر هناك
+
+102
+00:07:17,330 --> 00:07:21,210
+بسبب أن الحكومة تحتاج المزيد من المعلومات قبل أن
+
+103
+00:07:21,210 --> 00:07:26,870
+تتمكن من اختيار قرار عن الانتجار؟ نعم بالضبط أكثر
+
+104
+00:07:26,870 --> 00:07:29,510
+المستحيل أننا نحتاج المزيد من المعلومات لأن
+
+105
+00:07:29,510 --> 00:07:34,930
+التطبيق الذي تم تسمح به البيانات كانت تسمح بانتجار
+
+106
+00:07:34,930 --> 00:07:38,090
+تسمح ببيانات تسمح ببيانات تسمح ببيانات تسمح
+
+107
+00:07:38,090 --> 00:07:39,150
+ببيانات تسمح ببيانات تسمح ببيانات تسمح ببيانات
+
+108
+00:07:39,150 --> 00:07:40,110
+تسمح ببيانات تسمح ببيانات تسمح ببيانات تسمح
+
+109
+00:07:40,110 --> 00:07:40,250
+ببيانات تسمح ببيانات تسمح ببيانات تسمح ببيانات
+
+110
+00:07:40,250 --> 00:07:42,750
+تسمح ببيانات تسمح ببيانات تسمح ببيانات تسمح
+
+111
+00:07:42,750 --> 00:07:46,380
+ببيانات تسمح ببيWe need to know exactly what
+
+112
+00:07:46,380 --> 00:07:48,660
+happened to the amount of money which was
+
+113
+00:07:48,660 --> 00:07:51,300
+mentioned in page 2 for example We need to know
+
+114
+00:07:51,300 --> 00:07:54,980
+all details, we need to get some witnesses, we can
+
+115
+00:07:54,980 --> 00:07:58,060
+take some statements So what we can do, we can
+
+116
+00:07:58,060 --> 00:08:01,740
+delay, two weeks, four weeks, it depends on the
+
+117
+00:08:01,740 --> 00:08:04,720
+situation and it depends how much work the judge
+
+118
+00:08:04,720 --> 00:08:07,840
+can have, can delay the case for a few days or for
+
+119
+00:08:07,840 --> 00:08:11,380
+a few weeksالمرة القادمة سنحصل على أكتر معلومات
+
+120
+00:08:11,380 --> 00:08:14,140
+ونستطيع اختيار اختيار اختيار اختيار اختيار اختيار
+
+121
+00:08:14,140 --> 00:08:14,740
+اختيار اختيار اختيار اختيار اختيار اختيار اختيار
+
+122
+00:08:14,740 --> 00:08:16,800
+اختيار اختيار اختيار اختيار اختيار اختيار اختيار
+
+123
+00:08:16,800 --> 00:08:16,940
+اختيار اختيار اختيار اختيار اختيار اختيار اختيار
+
+124
+00:08:16,940 --> 00:08:19,880
+اختيار اختيار اختيار اختيار اختيار اختيار اختيار
+
+125
+00:08:19,880 --> 00:08:26,200
+اختيار اختيار اختيار اختيار اختيار اختيار اختيار
+
+126
+00:08:26,200 --> 00:08:29,360
+اختيار اختيار اختيار اختيار اختيار اختيار اختيار
+
+127
+00:08:29,360 --> 00:08:32,880
+اختيار اختيار ا
+
+128
+00:08:35,760 --> 00:08:40,100
+refuse، dismiss what؟ ده هو ال petition، we say
+
+129
+00:08:40,100 --> 00:08:43,560
+this petition we have some .. لأ لأحت الاتهام و
+
+130
+00:08:43,560 --> 00:08:48,620
+لأحت الدعوة، this petition is dismissedwe cannot
+
+131
+00:08:48,620 --> 00:08:51,500
+see it anymore we cannot look at it because this
+
+132
+00:08:51,500 --> 00:08:54,780
+is not appropriate we can dismiss petition perhaps
+
+133
+00:08:54,780 --> 00:08:58,840
+maybe maybe because administration order would be
+
+134
+00:08:58,840 --> 00:09:01,440
+more appropriate i know that you will not be
+
+135
+00:09:01,440 --> 00:09:04,640
+understand you will not understand such point if
+
+136
+00:09:04,640 --> 00:09:08,720
+you don't attend the class there is something
+
+137
+00:09:08,720 --> 00:09:11,360
+called administration order this we have to take
+
+138
+00:09:11,360 --> 00:09:15,940
+it after a few slides one of the alternativesأحد
+
+139
+00:09:15,940 --> 00:09:21,840
+التغييرات للمغامرة هي تسميها اتفاق إدارة إذا كان
+
+140
+00:09:21,840 --> 00:09:28,220
+المال في الوقت أقل من 5000 ريال أقل من 5000 ريال
+
+141
+00:09:28,220 --> 00:09:34,900
+فلا يوجد مغامرة اختيارها إذا كان المال أقل من 5000
+
+142
+00:09:34,900 --> 00:09:38,400
+ريال كل الوقت لا يوجد مغامرة يمكن أن يكون هناك
+
+143
+00:09:38,400 --> 00:09:42,970
+اتفاق إدارةهنا لا يوجد مغامرة، فالدكتور سيدفع
+
+144
+00:09:42,970 --> 00:09:48,290
+المدفعات للحكومة، حتى ينتهي كل المدفعات، لأن خمس
+
+145
+00:09:48,290 --> 00:09:52,270
+ألف دولار ليس كثير من المال، خمس ألف دولار يعني
+
+146
+00:09:52,270 --> 00:09:56,250
+حوالي اcht ألف دولار، ليس كثيرعندما يأتي الناس
+
+147
+00:09:56,250 --> 00:10:00,130
+للعمل و كان شخص ما ميت من 8000$ لكي يكون مغامر،
+
+148
+00:10:00,130 --> 00:10:03,590
+ليس صحيحًا، يمكن أن تعطي الشخص المزيد من الوقت و
+
+149
+00:10:03,590 --> 00:10:07,410
+المزيد من الوقت لتعطيه و هذا يمكن أن يكون واحد من
+
+150
+00:10:07,410 --> 00:10:10,630
+الأسباب، في بعض الأحيان، يمكن أن يتم إعادة
+
+151
+00:10:10,630 --> 00:10:12,230
+الموضوع، الموضوع يمكن أن يتم إعادة الموضوع،
+
+152
+00:10:12,230 --> 00:10:13,230
+الموضوع يمكن أن يتم إعادة الموضوع، الموضوع يمكن أن
+
+153
+00:10:13,230 --> 00:10:16,290
+يتم إعادة الموضوع، الموضوع يمكن أن يتم إعادة
+
+154
+00:10:16,290 --> 00:10:18,330
+الموضوع، الموضوع يمكن أن يتم إعادة الموضوع يمكن أن
+
+155
+00:10:18,330 --> 00:10:22,450
+يتم إعادة الموضوع يمكن أن يتم إعادة الموضbecause
+
+156
+00:10:22,450 --> 00:10:27,050
+maybe there was no reason to have bankruptcy maybe
+
+157
+00:10:27,050 --> 00:10:30,490
+because the debtor can prove that he can pay the
+
+158
+00:10:30,490 --> 00:10:33,050
+money for any reason it's up to the judge he can
+
+159
+00:10:33,050 --> 00:10:36,110
+decide because he have the discretion to decide if
+
+160
+00:10:36,110 --> 00:10:40,810
+we can take a decision like this or not if we can
+
+161
+00:10:40,810 --> 00:10:43,170
+take a decision of bankruptcy or can dismiss the
+
+162
+00:10:43,170 --> 00:10:47,410
+whole petition dismiss يعني إلغاء أو نترك القضية
+
+163
+00:10:47,410 --> 00:10:55,700
+نترك القضية خالصالثالث فرصة هي IVA إذا كنت لست
+
+164
+00:10:55,700 --> 00:10:59,320
+مدرسة ثالث
+
+165
+00:10:59,320 --> 00:11:05,060
+فرصة تسمى IVA كان لديناها السابق مرة IVA هي تجارب
+
+166
+00:11:05,060 --> 00:11:10,500
+فلانتري في هذه الحالة يمكن أن يقوم الشرطة بإدارة
+
+167
+00:11:10,500 --> 00:11:15,180
+هو ليس الشرطةSuggest that somebody which is called
+
+168
+00:11:15,180 --> 00:11:17,900
+insolvency practitioner which we're gonna look at
+
+169
+00:11:17,900 --> 00:11:21,960
+next slide to see He is the trustee which is
+
+170
+00:11:21,960 --> 00:11:23,960
+something important we have to keep in our mind
+
+171
+00:11:23,960 --> 00:11:27,980
+trustee Just
+
+172
+00:11:27,980 --> 00:11:30,620
+remind me after we finish here recording I'm gonna
+
+173
+00:11:30,620 --> 00:11:33,020
+talk about the exam just for two minutes which I'm
+
+174
+00:11:33,020 --> 00:11:34,300
+gonna explain sometimes you're gonna have
+
+175
+00:11:34,300 --> 00:11:38,120
+questions asking you to differentiate between two
+
+176
+00:11:38,120 --> 00:11:42,550
+thingsماذا يعني مثلًا؟ انفجار غير مفروض و غير
+
+177
+00:11:42,550 --> 00:11:47,190
+مفروض انفجار غير مفروض انفجار
+
+178
+00:11:47,190 --> 00:11:47,930
+غير مفروض انفجار غير مفروض انفجار غير مفروض انفجار
+
+179
+00:11:47,930 --> 00:11:48,530
+غير مفروض انفجار غير مفروض انفجار غير مفروض انفجار
+
+180
+00:11:48,530 --> 00:11:49,610
+غير مفروض انفجار غير مفروض انفجار غير مفروض انفجار
+
+181
+00:11:49,610 --> 00:11:50,010
+غير مفروض انفجار غير مفروض انفجار غير مفروض انفجار
+
+182
+00:11:50,010 --> 00:11:50,010
+غير مفروض انفجار غير مفروض انفجار غير مفروض انفجار
+
+183
+00:11:50,010 --> 00:12:06,670
+غير مفروض انفجار غير مفروض انفجار غير مفروض انفجار
+
+184
+00:12:06,670 --> 00:12:11,930
+غير مهناك سبب لإصلاح أن هذا الـ debtor يمكن أن
+
+185
+00:12:11,930 --> 00:12:14,630
+يدفع المال مرة أخرى ولكنه سيحتاج المزيد من الوقت
+
+186
+00:12:14,630 --> 00:12:18,690
+كما شهدنا بالأسباب السابقة في هذه الحالة نستطيع أن
+
+187
+00:12:18,690 --> 00:12:23,350
+ندفع مؤسسة في هذه الحالة مؤسسة اسمها Insolvency
+
+188
+00:12:23,350 --> 00:12:26,310
+Practitioner يمكن أن يكون مستخدم يمكن أن يكون
+
+189
+00:12:26,310 --> 00:12:32,090
+مستخدم او اي شخص آخر هذا الشخص مع الـ debtor سيصنع
+
+190
+00:12:32,090 --> 00:12:36,570
+برنامج اقتراح ويقوم بإعطاء كل المعلومات المحتاجة
+
+191
+00:12:37,890 --> 00:12:41,810
+القانون الاجتماعي والمال والمال اللي لدينا
+
+192
+00:12:41,810 --> 00:12:45,430
+والسيارات كل شيء اللي لدينا يجب أن يكون مصطلح في
+
+193
+00:12:45,430 --> 00:12:53,110
+قطع كتابة ويقوم بتصميمها للمستخدمين لو اقبلوا هذا
+
+194
+00:12:53,110 --> 00:12:57,770
+الانتجار كما يجب أن نشرحه في أكتر تفاصيل بعد 2 او
+
+195
+00:12:57,770 --> 00:13:02,610
+3 أسلوب اذا اقبلوا هذا الانتجار فسيكون لدينا IVA
+
+196
+00:13:03,340 --> 00:13:06,480
+وبعد ذلك يجب أن نرسلها إلى الحكومة لإعطائها وليس
+
+197
+00:13:06,480 --> 00:13:10,140
+بانكروبسيا، لذا رقم واحد، اثنان، ثلاثة، لا قرار
+
+198
+00:13:10,140 --> 00:13:13,580
+بانكروبسيا يمكن أن يتم إصلاحه، لا، لأن خيار
+
+199
+00:13:13,580 --> 00:13:18,100
+الأخير، الفرصة الأخيرة هي إجراء حركة بانكروبسيا،
+
+200
+00:13:18,100 --> 00:13:24,660
+يجب أن نبقى به إلى الأخير، يجب أن نستخدم جميع
+
+201
+00:13:24,660 --> 00:13:29,120
+الاختيارات في البداية، لأن حركة بانكروبسياIt means
+
+202
+00:13:29,120 --> 00:13:33,020
+the end of the life the end of business life then
+
+203
+00:13:33,020 --> 00:13:34,780
+we will not be able to come back to business
+
+204
+00:13:34,780 --> 00:13:41,360
+easily in the future last option for the judge is
+
+205
+00:13:41,360 --> 00:13:49,100
+bankruptcy order bankruptcy decision judgment this
+
+206
+00:13:49,100 --> 00:13:52,790
+is the final decision can beوهو مجرد قانون مجرد
+
+207
+00:13:52,790 --> 00:13:54,230
+قانون مجرد قانون مجرد قانون مجرد قانون مجرد قانون
+
+208
+00:13:54,230 --> 00:13:57,050
+مجرد قانون مجرد قانون مجرد قانون مجرد قانون مجرد
+
+209
+00:13:57,050 --> 00:14:00,150
+قانون مجرد قانون مجرد قانون مجرد قانون مجرد قانون
+
+210
+00:14:00,150 --> 00:14:01,410
+مجرد قانون مجرد قانون مجرد قانون مجرد قانون مجرد
+
+211
+00:14:01,410 --> 00:14:06,830
+قانون مجرد قانون مجرد قانون مجرد قانون مجرد قانون
+
+212
+00:14:06,830 --> 00:14:08,330
+مجرد قانون مجرد قانون مجرد قانون مجرد قانون مجرد
+
+213
+00:14:08,330 --> 00:14:15,650
+قانون مجرد قانون مجرد قانون مجرد
+
+214
+00:14:23,300 --> 00:14:26,320
+سبسكتفات ممكن تتم إصدارها من الحكومة، إذا لم تكن
+
+215
+00:14:26,320 --> 00:14:31,280
+المال عالي، إذا لم تكن المال أقل من 20 ألف pound،
+
+216
+00:14:31,280 --> 00:14:34,460
+أعني في الانتجار، الناس أحيانًا يمكن أن تكون مالية
+
+217
+00:14:34,460 --> 00:14:40,920
+مليون دولارعشان عشان عشان عشان عشان عشان عشان عشان
+
+218
+00:14:40,920 --> 00:14:41,560
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+219
+00:14:41,560 --> 00:14:41,940
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+220
+00:14:41,940 --> 00:14:41,980
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+221
+00:14:41,980 --> 00:14:41,980
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+222
+00:14:41,980 --> 00:14:41,980
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+223
+00:14:41,980 --> 00:14:42,020
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+224
+00:14:42,020 --> 00:15:04,960
+عشان عشان عشان عشان عشان عشان عش
+
+225
+00:15:05,390 --> 00:15:10,870
+هو لم يقبل IVA في هذه الحالة سوف نعطيه برنامج هذا
+
+226
+00:15:10,870 --> 00:15:16,270
+البرنامج سيساعد في تسريع البرنامج هذا البرنامج
+
+227
+00:15:16,270 --> 00:15:19,170
+سيساعد في تسريع البرنامج الوثيق الوثيق الوثيق
+
+228
+00:15:19,170 --> 00:15:22,110
+الوثيق الوثيق الوثيق الوثيق الوثيق الوثيق الوثيق
+
+229
+00:15:22,110 --> 00:15:23,950
+الوثيق الوثيق الوثيق الوثيق الوثيق الوثيق الوثيق
+
+230
+00:15:23,950 --> 00:15:24,010
+الوثيق الوثيق الوثيق الوثيق الوثيق الوثيق الوثيق
+
+231
+00:15:24,010 --> 00:15:30,150
+الوثيق الوثيق الوثيق الوثيق الوثيق الوثيق الوثيق
+
+232
+00:15:30,150 --> 00:15:34,450
+الو
+
+233
+00:15:34,720 --> 00:15:39,620
+ممكن تبقى 3 سنة و انا سأشرح كيف يمكن ان يكون هذا
+
+234
+00:15:39,620 --> 00:15:48,180
+الوضع اذا كان لدينا امرتكاب اذا كان لدينا
+
+235
+00:15:48,180 --> 00:15:51,060
+امرتكاب اذا كان لدينا امرتكاب اذا كان لدينا
+
+236
+00:15:51,060 --> 00:15:51,460
+امرتكاب اذا كان لدينا امرتكاب اذا كان لدينا
+
+237
+00:15:51,460 --> 00:15:52,620
+امرتكاب اذا كان لدينا امرتكاب اذا كان لدينا
+
+238
+00:15:52,620 --> 00:15:53,220
+امرتكاب اذا كان لدينا امرتكاب اذا كان لدينا
+
+239
+00:15:53,220 --> 00:15:53,500
+امرتكاب اذا كان لدينا امرتكاب اذا كان لدينا
+
+240
+00:15:53,500 --> 00:15:54,160
+امرتكاب اذا كان لدينا امرتكاب اذا كان لدينا
+
+241
+00:15:54,160 --> 00:15:56,520
+امرتكاب اذا كان لدينا امرتكاب اذا كان لدينا
+
+242
+00:15:56,520 --> 00:15:59,260
+امرتكاب اذا كان لدينا امرتكاب اذا كان لدينا امر
+
+243
+00:15:59,750 --> 00:16:01,590
+عندما تحصل على قيمة صغيرة من المال، فيمكنك أن
+
+244
+00:16:01,590 --> 00:16:10,690
+تتجارب بعد 12 أشهر، وهو سيكون هنا في 2002 من
+
+245
+00:16:10,690 --> 00:16:14,150
+اليوم عندما تحصل على حرارة، فتصبح حرارة، أليس
+
+246
+00:16:14,150 --> 00:16:21,010
+كذلك؟ أفضل أن تصبح حرارة من وقت الحرارة
+
+247
+00:16:22,560 --> 00:16:27,840
+ولكن عندما تكون لديك دستجارة دستجارة يعني حرية لا
+
+248
+00:16:27,840 --> 00:16:32,240
+أحد يمكن يطلب منك أي شيء في هذه الوقت هذا يمكن أن
+
+249
+00:16:32,240 --> 00:16:35,200
+يكون أحيانا يمكن أن يكون عامة يمكن أن يكون عامتين
+
+250
+00:16:35,200 --> 00:16:36,260
+يمكن أن يكون عامتين يمكن أن يكون عامتين يمكن أن
+
+251
+00:16:36,260 --> 00:16:36,560
+يكون عامتين يمكن أن يكون عامتين يمكن أن يكون
+
+252
+00:16:36,560 --> 00:16:36,720
+عامتين يمكن أن يكون عامتين يمكن أن يكون عامتين
+
+253
+00:16:36,720 --> 00:16:37,280
+يمكن أن يكون عامتين يمكن أن يكون عامتين يمكن أن
+
+254
+00:16:37,280 --> 00:16:37,640
+يكون عامتين يمكن أن يكون عامتين يمكن أن يكون
+
+255
+00:16:37,640 --> 00:16:38,620
+عامتين يمكن أن يكون عامتين يمكن أن يكون عامتين
+
+256
+00:16:38,620 --> 00:16:41,780
+يمكن أن يكون عامتين يمكن أن يكون عامتين يمكن أن
+
+257
+00:16:41,780 --> 00:16:50,000
+يكون عامتين ي
+
+258
+00:16:50,690 --> 00:16:54,290
+إذا كان هذا الشخص يخاطر، فهناك عديد من الأسباب
+
+259
+00:16:54,290 --> 00:16:57,330
+التي يمكن أن يستخدمها القاضي و يقوم باختياره نفسه
+
+260
+00:16:57,330 --> 00:17:05,690
+الأقل من الوقت يمكن أن يكون 12 أشهر أو 1 عام في
+
+261
+00:17:05,690 --> 00:17:10,150
+الواقع إذا كنت مغامر بعد 1 عام، يمكنني الذهاب إلى
+
+262
+00:17:10,150 --> 00:17:13,230
+الحجر لديه تجارب تجارب افراطية الأفراطية الأفراطية
+
+263
+00:17:13,230 --> 00:17:13,290
+الأفراطية الأفراطية الأفراطية الأفراطية الأفراطية
+
+264
+00:17:13,290 --> 00:17:14,430
+الأفراطية الأفراطية الأفراطية الأفراطية الأفراطية
+
+265
+00:17:14,430 --> 00:17:15,130
+الأفراطية الأفراطية الأفراطية الأفراطية الأفراطية
+
+266
+00:17:15,130 --> 00:17:16,710
+الأفراطية الأفراطية الأفراطية الأفراطية الأفراطية
+
+267
+00:17:16,710 --> 00:17:21,520
+الأفهذا يمكن أن يكون سنة او اثنين او اثنين او
+
+268
+00:17:21,520 --> 00:17:21,820
+اثنين او اثنين او اثنين او اثنين او اثنين او اثنين
+
+269
+00:17:21,820 --> 00:17:24,660
+او اثنين او اثنين او اثنين او اثنين او اثنين او
+
+270
+00:17:24,660 --> 00:17:25,500
+اثنين او اثنين او اثنين او اثنين او اثنين او اثنين
+
+271
+00:17:25,500 --> 00:17:26,260
+او اثنين او اثنين او اثنين او اثنين او اثنين او
+
+272
+00:17:26,260 --> 00:17:27,520
+اثنين او اثنين او اثنين او اثنين او اثنين او اثنين
+
+273
+00:17:27,520 --> 00:17:46,380
+او اثنين او اثنين او اثنين او اثنين او اثنين او
+
+274
+00:17:46,380 --> 00:17:51,880
+اثوهو ما يسمى كثيرا من الأسات غير مفتوحة في وقت ما
+
+275
+00:17:51,880 --> 00:17:56,380
+بعد تحويل الشركة حتى يكون لدينا هذه التحويلة اي
+
+276
+00:17:56,380 --> 00:17:59,900
+أكتر المال اللي يجعله الشركة تحويله يمكنك أن تحصل
+
+277
+00:17:59,900 --> 00:18:02,960
+على شيء مثل ما سنشاهده في التعليقات القادمة اي
+
+278
+00:18:02,960 --> 00:18:07,720
+أكتر المال اللي يجعله تحويله سيأخذه منه ويعطيه
+
+279
+00:18:07,720 --> 00:18:10,280
+للتواصل اللي يجعله تحويله اكتر المال اللي يجعله
+
+280
+00:18:10,280 --> 00:18:13,120
+تحويله تحويله
+
+281
+00:18:13,650 --> 00:18:16,790
+أنت لن تدفعه، نعرف الفرق بين الانتجار والانتجار
+
+282
+00:18:16,790 --> 00:18:19,710
+الانتجار وليس الانتجار، هل كذلك؟ نحن لدينا أساتذ
+
+283
+00:18:19,710 --> 00:18:22,470
+انتجار وليس انتجار وليس انتجار وليس انتجار وليس
+
+284
+00:18:22,470 --> 00:18:22,690
+انتجار وليس انتجار وليس انتجار وليس انتجار وليس
+
+285
+00:18:22,690 --> 00:18:24,030
+انتجار وليس انتجار وليس انتجار وليس انتجار وليس
+
+286
+00:18:24,030 --> 00:18:34,410
+انتجار وليس انتجار وليس انتجار وليس
+
+287
+00:18:34,410 --> 00:18:38,790
+انتجار وليس انتجار وليس انتجار وليس انتجار وليس
+
+288
+00:18:38,790 --> 00:18:41,710
+انتجار وليس انتجار وليس انتجار وليس انتجار وليس
+
+289
+00:18:41,710 --> 00:18:47,410
+انتجار وليعندما تكون لديك أساتذة غير مجالية حتى
+
+290
+00:18:47,410 --> 00:18:51,250
+وقت أن تكون لديك استخدام فإن المال الأكتر اللي
+
+291
+00:18:51,250 --> 00:18:55,410
+تدفعه سيكون أعطيه للمؤسسة ولكن عندما تكون لديك
+
+292
+00:18:55,410 --> 00:18:57,670
+استخدام فإن تكون لديك استخدام فإن تكون لديك
+
+293
+00:18:57,670 --> 00:18:58,870
+استخدام فإن تكون لديك استخدام فإن تكون لديك
+
+294
+00:18:58,870 --> 00:19:02,810
+استخدام فإن تكون لديك استخدام فإن تكون لديك
+
+295
+00:19:02,810 --> 00:19:05,350
+استخدام فإن تكون لديك استخدام فإن تكون لديك
+
+296
+00:19:05,350 --> 00:19:07,410
+استخدام فإن تكون لديك استخدام فإن تكون لديك
+
+297
+00:19:07,410 --> 00:19:10,030
+استخدام فإن تكون لديك استخدام فإن تكون لديك
+
+298
+00:19:10,030 --> 00:19:11,570
+استخدام فإن
+
+299
+00:19:15,240 --> 00:19:17,680
+الان كما ترى نحن لدينا اثنين نوع من المصادر
+
+300
+00:19:17,680 --> 00:19:22,420
+المصادر هما اثنين و هذا يمكن أن يكون سؤال الاختلاف
+
+301
+00:19:22,420 --> 00:19:28,840
+بين اثنين مصادر رقم واحد يسمى مصادر مصادر مصادر و
+
+302
+00:19:28,840 --> 00:19:30,440
+اخر مصادر مصادر مصادر مصادر و اخر مصادر مصادر
+
+303
+00:19:30,440 --> 00:19:34,160
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+304
+00:19:34,160 --> 00:19:37,740
+مصادر مصادر
+
+305
+00:19:37,740 --> 00:19:41,080
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+306
+00:19:41,080 --> 00:19:41,080
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+307
+00:19:41,080 --> 00:19:45,180
+مصادر مصادر مصادرالمستخدم الواضح هو شخص يعني شخص
+
+308
+00:19:45,180 --> 00:19:46,080
+يعني شخص يعني شخص يعني شخص يعني شخص يعني شخص يعني
+
+309
+00:19:46,080 --> 00:19:46,680
+شخص يعني شخص يعني شخص يعني شخص يعني شخص يعني شخص
+
+310
+00:19:46,680 --> 00:19:48,440
+يعني شخص يعني شخص يعني شخص يعني شخص يعني شخص يعني
+
+311
+00:19:48,440 --> 00:19:49,540
+شخص يعني شخص يعني شخص يعني شخص يعني شخص يعني شخص
+
+312
+00:19:49,540 --> 00:19:51,220
+يعني شخص يعني شخص يعني شخص يعني شخص يعني شخص يعني
+
+313
+00:19:51,220 --> 00:19:51,900
+شخص يعني شخص يعني شخص يعني شخص يعني شخص يعني شخص
+
+314
+00:19:51,900 --> 00:19:54,140
+يعني شخص يعني شخص يعني شخص يعني شخص يعني شخص يعني
+
+315
+00:19:54,140 --> 00:19:59,960
+شخص يعني شخص
+
+316
+00:19:59,960 --> 00:20:07,500
+يعني شخص
+
+317
+00:20:07,500 --> 00:20:11,850
+يعالثانية الوظائف هنا انظر إلى الوظائف هذا يمكن أن
+
+318
+00:20:11,850 --> 00:20:18,270
+يكون ملحق مستخدم مستخدم مستخدم مستخدم من من؟ من
+
+319
+00:20:18,270 --> 00:20:22,250
+الحكومة الحكومة ولكن هذا المستخدم الانسولفانسي
+
+320
+00:20:22,250 --> 00:20:28,470
+ملحق من ال .. من البيانات ملحق من الحكومة وملحق من
+
+321
+00:20:28,470 --> 00:20:34,110
+البيانات بالإضافة
+
+322
+00:20:34,110 --> 00:20:40,080
+إلى هذا ماذا يفعلون؟ ماذا تفعلون؟مهمة مستخدم الـ
+
+323
+00:20:40,080 --> 00:20:47,080
+official receiver هو إجراء المال، إجراء المواد،
+
+324
+00:20:47,080 --> 00:20:50,420
+وهو ما يسمى بـ Bankruptcy Estate كما كانت قبلها،
+
+325
+00:20:50,420 --> 00:20:55,060
+وهو ما يسمى بـ Bankruptcy Estate كل المال، المال
+
+326
+00:20:55,060 --> 00:21:00,020
+والمواد الخاصة بالبيانات، يتم إجراءها الـ official
+
+327
+00:21:00,020 --> 00:21:07,550
+receiverوهو سيكون شخص مثقف عن المال وينظر إلى كل
+
+328
+00:21:07,550 --> 00:21:13,430
+شيء ويقوم بتجارب يمكنه أن يقوم بتقليل المال ويقوم
+
+329
+00:21:13,430 --> 00:21:14,170
+بتقليل المال ويقوم بتقليل المال ويقوم بتقليل المال
+
+330
+00:21:14,170 --> 00:21:14,770
+ويقوم بتقليل المال ويقوم بتقليل المال ويقوم بتقليل
+
+331
+00:21:14,770 --> 00:21:16,010
+المال ويقوم بتقليل المال ويقوم بتقليل المال ويقوم
+
+332
+00:21:16,010 --> 00:21:16,110
+بتقليل المال ويقوم بتقليل المال ويقوم بتقليل المال
+
+333
+00:21:16,110 --> 00:21:16,150
+ويقوم بتقليل المال ويقوم بتقليل المال ويقوم بتقليل
+
+334
+00:21:16,150 --> 00:21:19,830
+المال ويقوم بتقليل المال ويقوم بتقليل المال ويقوم
+
+335
+00:21:19,830 --> 00:21:24,070
+بتقليل المال ويقوم بتقليلالدتر يقوم بالمخطط،
+
+336
+00:21:24,070 --> 00:21:31,490
+بمخطط، بمفهوم، بمساعدة الدتر، كما يقوم الدتر
+
+337
+00:21:31,490 --> 00:21:34,670
+بمخطط، بمخطط، بمساعدة الدتر، كما يقوم الدتر بمخطط،
+
+338
+00:21:34,670 --> 00:21:37,570
+بمخطط، بمساعدة الدتر، كما يقوم الدتر بمخطط، بمخطط،
+
+339
+00:21:37,570 --> 00:21:38,150
+بمساعدة الدتر، كما يقوم الدتر بمخطط، بمساعدة
+
+340
+00:21:38,150 --> 00:21:38,750
+الدتر، كما يقوم الدتر بمخطط، بمساعدة الدتر، كما
+
+341
+00:21:38,750 --> 00:21:40,150
+يقوم الدتر بمخطط، بمساعدة الدتر، كما يقوم الدتر
+
+342
+00:21:40,150 --> 00:21:45,190
+بمخطط، بمساعدة الدتر، كماوهو ري .. ري .. لا ري با
+
+343
+00:21:45,190 --> 00:21:48,630
+.. ري با .. ري با .. ري با .. ري با .. ري با .. ري
+
+344
+00:21:48,630 --> 00:21:50,450
+با .. ري با .. ري با .. ري با .. ري با .. ري با ..
+
+345
+00:21:50,450 --> 00:21:51,250
+ري با .. ري با .. ري با .. ري با .. ري با .. ري با
+
+346
+00:21:51,250 --> 00:21:51,630
+.. ري با .. ري با .. ري با .. ري با .. ري با .. ري
+
+347
+00:21:51,630 --> 00:21:51,910
+با .. ري با .. ري با .. ري با .. ري با .. ري با ..
+
+348
+00:21:51,910 --> 00:21:53,250
+ري با .. ري با .. ري با .. ري با .. ري با .. ري با
+
+349
+00:21:53,250 --> 00:21:57,390
+.. ري با .. ري با .. ري با .. ري با .. ري با .. ري
+
+350
+00:21:57,390 --> 00:22:08,850
+با .. ري با .. ري
+
+351
+00:22:08,850 --> 00:22:12,300
+بانحن نستطيع أن نحصل على موضوع جديد يمكن أن يكون
+
+352
+00:22:12,300 --> 00:22:17,120
+لعامين او ثلاث عامين فهو مختلف عن تجارب مجتمع
+
+353
+00:22:17,120 --> 00:22:22,240
+مجتمع مجتمع مجتمع لا هذا بالطبع هذا هو نقطة جيدة
+
+354
+00:22:22,240 --> 00:22:25,280
+أعني هذا هو تجارب مجتمع مجتمع مجتمع اكتشاف مجتمع
+
+355
+00:22:25,280 --> 00:22:26,680
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+356
+00:22:26,680 --> 00:22:27,580
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+357
+00:22:27,580 --> 00:22:28,960
+مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع مجتمع
+
+358
+00:22:28,960 --> 00:22:38,020
+مجتمع مجتمع مجتمع مجتمع مجتمع
+
+359
+00:22:39,680 --> 00:22:43,220
+هو ليس صعبًا لدينا أربع اختلافات، هل يمكننا أن
+
+360
+00:22:43,220 --> 00:22:46,320
+نرىها مرة أخرى؟ رقم أول، هذا المستخدم الرئيسي هو
+
+361
+00:22:46,320 --> 00:22:52,800
+مستخدم مجتمع مستخدم مستخدم مستخدم مستخدم مستخدم
+
+362
+00:22:52,800 --> 00:22:57,740
+مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم
+
+363
+00:22:57,740 --> 00:22:59,360
+مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم
+
+364
+00:22:59,360 --> 00:23:01,500
+مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم
+
+365
+00:23:01,500 --> 00:23:01,500
+مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم
+
+366
+00:23:01,500 --> 00:23:01,500
+مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم
+
+367
+00:23:01,500 --> 00:23:09,020
+مستانسلفانسي مدرسة في تجارب تجارب او IVA لان تجارب
+
+368
+00:23:09,020 --> 00:23:12,100
+تجارب و IVA هي الشيء اللي هي الشيء اللي هي الشيء
+
+369
+00:23:12,100 --> 00:23:17,200
+الواقعي المستخدم سيأخذ المال و يقوم بتقليل بين
+
+370
+00:23:17,200 --> 00:23:22,120
+الانسلفانسي مدرسة انسلفانسي مدرسة انسلفانسي مدرسة
+
+371
+00:23:22,120 --> 00:23:26,660
+انسلفانسي مدرسة انسلفانسي مدرسة انسلفانسي مدرسة
+
+372
+00:23:26,660 --> 00:23:30,240
+انسلفانسي
+
+373
+00:23:30,240 --> 00:23:30,280
+مدرسة انسلفانسي مدرسة انسلفانسي مدرسة انسلفانسي
+
+374
+00:23:30,280 --> 00:23:34,890
+مدرسة انسلفانسي مدرسة انسلفانسي مدرسةالذي سيخبر
+
+375
+00:23:34,890 --> 00:23:39,970
+الحرس و المالكين كيف نستطيع أن نعيدهم في المستقبل
+
+376
+00:23:39,970 --> 00:23:47,610
+عندما
+
+377
+00:23:47,610 --> 00:23:57,490
+يصبح ال data مخفف عندما يصبح ال data مخفف
+
+378
+00:24:02,570 --> 00:24:08,890
+وان ده كانبيه؟ وان دي court
+
+379
+00:24:08,890 --> 00:24:12,670
+made
+
+380
+00:24:12,670 --> 00:24:15,890
+the order for the bankrupts؟ when .. well the
+
+381
+00:24:15,890 --> 00:24:19,550
+dictator becomes bankrupt once we have bankruptcy
+
+382
+00:24:19,550 --> 00:24:20,090
+order
+
+383
+00:24:23,180 --> 00:24:26,780
+من هذه اللحظة، من قرار الانفجار عندما تم صنعه،
+
+384
+00:24:26,780 --> 00:24:30,080
+الراجل أو الفتاة اللي كانت قائدها قبلها، تصبح
+
+385
+00:24:30,080 --> 00:24:34,020
+انفجار، خلاص، قرار تم صنعه من قبل الحكومة، نحن
+
+386
+00:24:34,020 --> 00:24:36,260
+لدينا بعض الواجهات، و هذه يمكن أن تكون أسئلة
+
+387
+00:24:36,260 --> 00:24:38,180
+للحكومة، مثل الـ true أو الfalse، تستطيع أن
+
+388
+00:24:38,180 --> 00:24:43,240
+تذكرهم، تستطيع أن تتكلم عنهم، الواجهات، إذا أصبحت
+
+389
+00:24:43,240 --> 00:24:48,240
+انفجار، ماذا تتوقع؟ ماذا يمكن أن تفعل؟ أحد يصبح
+
+390
+00:24:48,240 --> 00:24:50,320
+انفجار، ماذا يمكن أن يفعل؟
+
+391
+00:24:54,680 --> 00:24:57,200
+even without looking, just think about it for a
+
+392
+00:24:57,200 --> 00:25:01,800
+minute, a bankrupt can do something? of course he
+
+393
+00:25:01,800 --> 00:25:02,100
+can do
+
+394
+00:25:05,400 --> 00:25:08,560
+يعني after he's bankrupted .. yes after and even
+
+395
+00:25:08,560 --> 00:25:14,000
+before يعني the duties .. he said that the debitor
+
+396
+00:25:14,000 --> 00:25:19,460
+has become bankrupted and talked with him and he's
+
+397
+00:25:19,460 --> 00:25:23,360
+a .. الفستي اللي هو الconvincive practitioners
+
+398
+00:25:23,360 --> 00:25:32,260
+okay he came again to the business okayThe
+
+399
+00:25:32,260 --> 00:25:35,920
+bankrupt must provide an information to the
+
+400
+00:25:35,920 --> 00:25:39,340
+official .. to the official professor .. to the
+
+401
+00:25:39,340 --> 00:25:42,820
+official about the financial information about it.
+
+402
+00:25:42,920 --> 00:25:46,380
+Okay that's one yeah. If he has an assets, he can
+
+403
+00:25:46,380 --> 00:25:52,930
+pay them and pay his ..مثلًا قالت أن جميع الأساسات
+
+404
+00:25:52,930 --> 00:25:59,190
+غير مجالية يجب أن يتم إعطائها للمجلد و بينما يتم
+
+405
+00:25:59,190 --> 00:26:03,610
+إعطائه المال المجاني والذي يجب أن يتم إعطائه
+
+406
+00:26:03,610 --> 00:26:08,030
+المجلد هو نفس الشيء يجب أن يتعامل مع الحكومة
+
+407
+00:26:08,030 --> 00:26:12,670
+ويعطيه الاناليزية الاناليزية حسنًا لذلك يجب أن
+
+408
+00:26:12,670 --> 00:26:18,170
+يتعامل مع الحكومة تمامًا المال الذي يصبح مغامر يجب
+
+409
+00:26:18,170 --> 00:26:22,170
+أن يعطي كل ما لدينا هنا في هذه النقطة الأولىيجب أن
+
+410
+00:26:22,170 --> 00:26:27,350
+يمنح المستخدم المصطلح كل المعلومات المحتاجة في
+
+411
+00:26:27,350 --> 00:26:32,690
+الأعمال الانترنتية خلال 21 أيام منذ الوقت الذي كان
+
+412
+00:26:32,690 --> 00:26:37,530
+طلبه منذ الوقت عندما المستخدم عندما المستخدم طلب
+
+413
+00:26:37,530 --> 00:26:40,010
+من المصطلح الانترنتي أن يطلب من البيانات أن تمنحه
+
+414
+00:26:40,010 --> 00:26:43,510
+المعلومات عن المجالات الانترنتية يجب أن يفعل ذلك
+
+415
+00:26:43,510 --> 00:26:51,440
+إذا لم يستطيع إذا لم يتعاونالتأثير سيكون عظيم يمكن
+
+416
+00:26:51,440 --> 00:26:56,060
+أن يكون مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+417
+00:26:56,060 --> 00:26:56,860
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+418
+00:26:56,860 --> 00:26:57,720
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+419
+00:26:57,720 --> 00:26:57,720
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+420
+00:26:57,720 --> 00:26:57,720
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+421
+00:26:57,720 --> 00:26:57,740
+مجرد مجرد مجرد مجرد
+
+422
+00:27:18,360 --> 00:27:21,180
+even if the assets were not related to the same
+
+423
+00:27:21,180 --> 00:27:25,280
+company he's .. no we're not talking about the
+
+424
+00:27:25,280 --> 00:27:27,360
+person it doesn't matter if it's a company or
+
+425
+00:27:27,360 --> 00:27:31,320
+human being if he was bankrupt because this
+
+426
+00:27:31,320 --> 00:27:34,020
+certain company and he has other companies the
+
+427
+00:27:34,020 --> 00:27:36,520
+assets of the other companies are handed to this
+
+428
+00:27:36,520 --> 00:27:38,340
+person no it's not like this you did not
+
+429
+00:27:38,340 --> 00:27:40,000
+understand the whole point from the beginning
+
+430
+00:27:40,000 --> 00:27:45,210
+bankruptcyوهو من يستطيع أن يطلب الانقلاب، اي شخص
+
+431
+00:27:45,210 --> 00:27:48,330
+يمكن أن يكون إنسان يمكن أن يكون فكتشس مثل شركة،
+
+432
+00:27:48,330 --> 00:27:52,550
+الآن هذا الشخص اللي تتكلم عنه، انه طلب انقلاب،
+
+433
+00:27:52,550 --> 00:27:55,450
+أليس كذلك؟ او انك تقول انه لديه شركة مختلفة، شركة
+
+434
+00:27:55,450 --> 00:27:59,010
+أخرى، الآن الشركة الأولى، إنها شركة مشاركة ربما،
+
+435
+00:27:59,010 --> 00:28:02,950
+لذلك لديها عقل غير محدد، ثم تصبح انقلاب، ثم يجب أن
+
+436
+00:28:02,950 --> 00:28:07,190
+تكون كل ما لديكأي شيء من المال غير مجلس ولكن
+
+437
+00:28:07,190 --> 00:28:12,150
+الشركة الثانية اللي تتكلم عنها تكون مثلا قيمة
+
+438
+00:28:12,150 --> 00:28:16,790
+محددة او اي شركة لديها اسم افضل انها شخصية مختلفة
+
+439
+00:28:16,790 --> 00:28:23,670
+شركة لديها اسم افضل نحن لا نستطيع نستطيع نأخذ
+
+440
+00:28:23,670 --> 00:28:27,070
+المال من الشخص الثاني انه ليس كذلك نحن نحكم في شخص
+
+441
+00:28:27,070 --> 00:28:30,390
+ما ان هذا الشخص فقد فقد فقد فقد فقد فقد فقد فقد
+
+442
+00:28:30,390 --> 00:28:31,050
+فقد فقد فقد فقد فقد فقد فقد فقد فقد فقد فقد فقد
+
+443
+00:28:31,050 --> 00:28:35,010
+فقد فقد فقد فقد فقد فقد فقد فقد فقد فقد
+
+444
+00:28:35,010 --> 00:28:35,010
+فقد فقد فقد فقد فقد فقد فقد فقد فقد فقد فقد فقد
+
+445
+00:28:35,010 --> 00:28:37,630
+فقد فقد فقد فقد فقد فقد فhe might have some shares
+
+446
+00:28:37,630 --> 00:28:40,530
+if he have some shares in a different company then
+
+447
+00:28:40,530 --> 00:28:43,530
+we can take his shares we can sell them but that
+
+448
+00:28:43,530 --> 00:28:46,190
+company it can be like you know I cannot own a
+
+449
+00:28:46,190 --> 00:28:49,190
+company myself unless if it's a limited liability
+
+450
+00:28:49,190 --> 00:28:52,330
+company like we said in the statesأو شركة شركة
+
+451
+00:28:52,330 --> 00:28:53,070
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+452
+00:28:53,070 --> 00:28:59,130
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+453
+00:28:59,130 --> 00:29:02,530
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+454
+00:29:02,530 --> 00:29:02,550
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+455
+00:29:02,550 --> 00:29:02,550
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+456
+00:29:02,550 --> 00:29:04,190
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+457
+00:29:04,190 --> 00:29:06,510
+شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة
+
+458
+00:29:06,510 --> 00:29:18,670
+شركة شركة
+
+459
+00:29:19,960 --> 00:29:26,720
+عندما يحدث هذا و أننا قررنا أن نتخلص من العرض، حتى
+
+460
+00:29:26,720 --> 00:29:31,920
+بعد ذلك، خلال التخلص، خلال التخلص، هذا ما يمكن أن
+
+461
+00:29:31,920 --> 00:29:34,900
+يكون قبل أن يكون لدينا تخلص من العرض، قبل أن يكون
+
+462
+00:29:34,900 --> 00:29:38,360
+التخلص لدينا تخلص من العرض، هذا ما يسمى تخلص من
+
+463
+00:29:38,360 --> 00:29:38,560
+العرض خلال
+
+464
+00:29:42,790 --> 00:29:46,730
+في وقت الانفجار، منذ وقت إصلاح الانفجار، إلى وقت
+
+465
+00:29:46,730 --> 00:29:51,390
+إيقاف المال، هذا مازل مبروك من الانفجار، أي مال
+
+466
+00:29:51,390 --> 00:29:57,890
+أكتر تجعله انفجار، يجب أن يتم إعلامه بالمؤسسات،
+
+467
+00:29:57,890 --> 00:30:04,850
+فهذا يعني أن الانفجار سيكون تحت حماية،
+
+468
+00:30:04,850 --> 00:30:10,240
+تحت حمايةكل الوقت اي مال اكتر تجعله يجب ان تعطيه
+
+469
+00:30:10,240 --> 00:30:14,960
+الى مؤسسة في أضافة لدراسة رقم 4 في الولايات
+
+470
+00:30:14,960 --> 00:30:21,900
+المتعاملة إذا كانت تعمل اي عملية عملية عملية عملية
+
+471
+00:30:21,900 --> 00:30:21,900
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+472
+00:30:21,900 --> 00:30:22,440
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+473
+00:30:22,440 --> 00:30:22,980
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+474
+00:30:22,980 --> 00:30:26,040
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+475
+00:30:26,040 --> 00:30:26,080
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+476
+00:30:26,080 --> 00:30:26,080
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+477
+00:30:26,080 --> 00:30:26,100
+عملية
+
+478
+00:30:37,260 --> 00:30:40,900
+هي حياة مختلفة، بداية جديدة، يمكن أن تكون مجاناً
+
+479
+00:30:40,900 --> 00:30:48,060
+رقم 4 كما قلت، يجب أن يتفرج، يتفرج نفسه كمال من
+
+480
+00:30:48,060 --> 00:30:52,460
+المال الذي أراد أن يستخدمه أو يريد أن يستخدمه كان
+
+481
+00:30:52,460 --> 00:30:57,860
+أكتر من 250 ريال. الأن بالإضافة إلى هذا، إذا كان
+
+482
+00:30:57,860 --> 00:31:01,670
+لديه حكومة بنكbuilding society in the UK they have
+
+483
+00:31:01,670 --> 00:31:05,130
+banks and they have building society building
+
+484
+00:31:05,130 --> 00:31:08,570
+society it means small banks they have small
+
+485
+00:31:08,570 --> 00:31:11,690
+financial institutes they call them building
+
+486
+00:31:11,690 --> 00:31:14,310
+society that's it's a term building society if
+
+487
+00:31:14,310 --> 00:31:17,630
+they have any account these will be closed the
+
+488
+00:31:17,630 --> 00:31:21,210
+accounts will be closed payments here he should
+
+489
+00:31:21,210 --> 00:31:23,690
+not make any direct payment to any of the
+
+490
+00:31:23,690 --> 00:31:31,070
+creditors all payments any extra money he makesبعد
+
+491
+00:31:31,070 --> 00:31:35,250
+ان يتخلص من المساعدة، يجب أن يتم إعطاء المساعدة
+
+492
+00:31:35,250 --> 00:31:39,870
+للمعارضة، وليس للمعارضة
+
+493
+00:31:41,930 --> 00:31:46,110
+يجب أن يقابل الحكومة في كل مرة يُطلب منه أن يقابل
+
+494
+00:31:46,110 --> 00:31:51,130
+الحكومة يجب أن يقابل الحكومة إذا لم يرفض سيكون
+
+495
+00:31:51,130 --> 00:31:53,870
+قابل الحكومة سيكون قابل الحكومة لذلك يجب أن يكون
+
+496
+00:31:53,870 --> 00:31:56,330
+صعب لمن ينظر إلى هذه النقطة هنا يجب أن يكون صعب
+
+497
+00:31:56,330 --> 00:32:01,270
+لشخص مثل هذا ليس شيء لتستمتع به كل شيء سيكون مقفل
+
+498
+00:32:01,270 --> 00:32:06,590
+في عملك ستكون مدعوة بكل المعلومات المالية و لن
+
+499
+00:32:06,590 --> 00:32:09,530
+تكون حرة حتى لتسجل في بعض الأحيان الناس لا
+
+500
+00:32:09,530 --> 00:32:12,580
+يستطيعون التسجلفي بعض الأحيان لن يتمكنوا من الخروج
+
+501
+00:32:12,580 --> 00:32:15,560
+من المنطقة التي يعيشون فيها. الكثير .. الكثير من
+
+502
+00:32:15,560 --> 00:32:19,300
+الانضمامات سيكون موضوع على الانفجار.
+
+503
+00:32:20,680 --> 00:32:25,120
+بالإضافة لدينا بعض المفاجأة. انظروا إلى المفاجأة.
+
+504
+00:32:25,320 --> 00:32:28,660
+إنها تبدو مثلها في بعض المناطق. المفاجأة في
+
+505
+00:32:28,660 --> 00:32:36,180
+الانفجار. رقم واحد، حنين.عندما يتم انفجار
+
+506
+00:32:36,180 --> 00:32:41,350
+الدكتورة، كل أساس الملائكة له يأتيIt's nothing
+
+507
+00:32:41,350 --> 00:32:45,870
+anyway including his home these are as you can see
+
+508
+00:32:45,870 --> 00:32:49,970
+disastrous long term implication for the long term
+
+509
+00:32:49,970 --> 00:32:53,630
+he will be poor all of or the rest of his life
+
+510
+00:32:53,630 --> 00:32:59,390
+most likely this bankrupt this bankrupt will be
+
+511
+00:32:59,390 --> 00:33:01,970
+poor for the rest of his life most likely because
+
+512
+00:33:01,970 --> 00:33:05,670
+any money he makes he have to be and he will not
+
+513
+00:33:05,670 --> 00:33:08,450
+be able to have the freedom to work in business
+
+514
+00:33:08,450 --> 00:33:16,010
+anymorenumber two جيدة restrictions placed upon
+
+515
+00:33:16,010 --> 00:33:19,790
+the bankrupt and the stigma of having to declare
+
+516
+00:33:19,790 --> 00:33:22,990
+oneself as a bankrupt for a certain transaction
+
+517
+00:33:22,990 --> 00:33:27,330
+it's a stigma once .. once you declareالاسم سيكون
+
+518
+00:33:27,330 --> 00:33:32,450
+في الكتابة، اسم الانفجار سيكون في الكتابة، كل شخص
+
+519
+00:33:32,450 --> 00:33:36,750
+في المجتمع سيعرف أن هذا المكان مغلق و هذا الرجل أو
+
+520
+00:33:36,750 --> 00:33:39,850
+هذه السيدة لا يعمل في الشركة بعد الأن لأنه أو انها
+
+521
+00:33:39,850 --> 00:33:46,030
+تصبح انفجار، لديه اهتمام نقلي ليس فقط عليه و حتى
+
+522
+00:33:46,030 --> 00:33:49,790
+في عائلته و أطفاله، هم لن يشعروا بإرادة شيء مثل
+
+523
+00:33:49,790 --> 00:33:53,510
+هذا، الناس سيشاهدونهمفي طريقة نجативة و حتى ان
+
+524
+00:33:53,510 --> 00:33:59,570
+تنظر في أوروبا الناس ستفكر انه بخير انه بخير اليوم
+
+525
+00:33:59,570 --> 00:34:02,970
+نخسر ربما في المستقبل نستطيع أن نصنع المال لهم شيء
+
+526
+00:34:02,970 --> 00:34:05,730
+يمكن أن يكون في بعض الأحيان طبيعي ولكن في مجتمعنا
+
+527
+00:34:05,730 --> 00:34:13,270
+الناس لن يقبله حتى اذا كان لديك قرار يمنحك الحرارة
+
+528
+00:34:13,270 --> 00:34:19,290
+و انت تعتقد ان الناس سيغفر عليكماذا تعتقد؟ بالطبع
+
+529
+00:34:19,290 --> 00:34:24,030
+انهم لن .. الناس هنا في مجتمعنا وحتى في أكتر دول
+
+530
+00:34:24,030 --> 00:34:29,670
+ثالث عالمين الناس الاستثناء لن يغفرون ويستمرون
+
+531
+00:34:29,670 --> 00:34:32,790
+بالطرح ان اذا لم يكونوا ناجحين في الحصول على المال
+
+532
+00:34:32,790 --> 00:34:37,090
+باستخدام نظام الحكومة يمكنهم الذهاب من نظام
+
+533
+00:34:37,090 --> 00:34:39,170
+التعامل التعامل التعامل التعامل التعامل التعامل
+
+534
+00:34:39,170 --> 00:34:40,130
+التعامل التعامل التعامل التعامل التعامل التعامل
+
+535
+00:34:40,130 --> 00:34:42,150
+التعامل التعامل التعامل التعامل التعامل التعامل
+
+536
+00:34:42,150 --> 00:34:42,330
+التعامل التعامل التعامل التعامل التعامل التعامل
+
+537
+00:34:42,330 --> 00:34:45,380
+التعامل التعامل التعامل التعامل التعامل التof
+
+538
+00:34:45,380 --> 00:34:50,300
+declaring somebody a bankrupt his business will be
+
+539
+00:34:50,300 --> 00:34:53,900
+immediately closed immediately it closed in
+
+540
+00:34:53,900 --> 00:34:56,920
+addition loss of any assets of value anything
+
+541
+00:34:56,920 --> 00:34:59,800
+which is important for you you might have the
+
+542
+00:34:59,800 --> 00:35:02,980
+house which you lived in for fifty years you might
+
+543
+00:35:02,980 --> 00:35:06,620
+lose it something you like so much like even
+
+544
+00:35:06,620 --> 00:35:08,740
+losing here the pension even the pension البنش
+
+545
+00:35:08,740 --> 00:35:13,600
+اللي هو التقاعدممكن تخسر حياتك، ممكن تخسر حياتك،
+
+546
+00:35:13,600 --> 00:35:17,800
+ممكن تخسر كل شيء لكي تدفع الناس الذين كنت من
+
+547
+00:35:17,800 --> 00:35:20,140
+المفروض أن تكون من البداية، وحتى هنا ممكن تخسر
+
+548
+00:35:20,140 --> 00:35:25,480
+الاناستيطانات اللي قد تحصل عليها في وقت الانتجار،
+
+549
+00:35:25,480 --> 00:35:30,640
+مثل انهيارات، في هذا الفرق، في عامين، عامين،
+
+550
+00:35:30,640 --> 00:35:33,600
+عامين، عامين، قبل أن يحاول هذا، هذا الشخص
+
+551
+00:35:33,600 --> 00:35:37,880
+الانتجاري أو الشخص الانتجاري، انهيارت مليون دولار
+
+552
+00:35:39,170 --> 00:35:43,390
+أبوه قد مات من هناك و انه قام باستخدامه و احصل على
+
+553
+00:35:43,390 --> 00:35:48,050
+مال جيد و هذا المال سيكون أخذ منه و سيكون أعطاه لـ
+
+554
+00:35:48,050 --> 00:35:52,890
+trustee و إذا حدث هذا .. إذا حدث هذا .. إذا حدث
+
+555
+00:35:52,890 --> 00:35:54,570
+هذا .. إذا حدث هذا .. إذا حدث هذا .. إذا حدث هذا
+
+556
+00:35:54,570 --> 00:35:54,570
+.. إذا حدث هذا .. إذا حدث هذا .. إذا حدث هذا ..
+
+557
+00:35:54,570 --> 00:35:54,570
+إذا حدث هذا .. إذا حدث هذا .. إذا حدث هذا .. إذا
+
+558
+00:35:54,570 --> 00:35:54,570
+حدث هذا .. إذا حدث هذا .. إذا حدث هذا .. إذا حدث
+
+559
+00:35:54,570 --> 00:35:54,570
+هذا .. إذا حدث هذا .. إذا حدث هذا .. إذا حدث هذا
+
+560
+00:35:54,570 --> 00:35:56,790
+.. إذا حدث هذا .. إذا حدث هذا .. إذا حدث هذا ..
+
+561
+00:35:56,790 --> 00:36:04,830
+إذا حدث هذا .. إذا
+
+562
+00:36:04,830 --> 00:36:05,910
+حدث هذا
+
+563
+00:36:09,200 --> 00:36:13,160
+المقالات المالية ستبقى مغلقة هنا في أضافة إلى جميع
+
+564
+00:36:13,160 --> 00:36:23,220
+هذه النقطة مكانة ماهي مقانة؟ مكانة في مجتمع
+
+565
+00:36:23,220 --> 00:36:30,100
+التسلسل مكانته في السوق سيخسره في أضافة إلى
+
+566
+00:36:30,100 --> 00:36:34,280
+الانتجار لا يستطيع حتى أن ينظم شركة لا يستطيع أن
+
+567
+00:36:34,280 --> 00:36:36,520
+يعمل لأشخاص أخرين لتنظيمه يستطيع أن يعمل، نعم
+
+568
+00:36:36,520 --> 00:36:41,770
+المال يستطيع أن يعمليمكنه أن يكون موظف، لكنه لن
+
+569
+00:36:41,770 --> 00:36:45,070
+يكون قادر على الحصول على عمل في مجلس التعامل، لا
+
+570
+00:36:45,070 --> 00:36:47,030
+يمكنه أن يكون مدير، لا يمكنه أن يكون في مجلس
+
+571
+00:36:47,030 --> 00:36:50,810
+سينيوري، لا يمكنه أن يكون مالكتر، لا يمكنه أن يركض
+
+572
+00:36:50,810 --> 00:36:54,410
+في الحكومة، لا يمكنه أن يركض في الحكومة الموجودة،
+
+573
+00:36:54,410 --> 00:36:59,150
+ترى؟ كثير من الانقلابات، ليس بسهولة، كثير منها،
+
+574
+00:36:59,150 --> 00:37:03,180
+حتى القدرةفي البنك هو سيخسرها .. سيخسرها .. حتى
+
+575
+00:37:03,180 --> 00:37:04,980
+إذا كنت تريد أن تكون .. إذا كنت تريد أن تكون لديك
+
+576
+00:37:04,980 --> 00:37:08,440
+موقع بنك جديد ، يمكنك أن تكون له .. لكن هذا موقع
+
+577
+00:37:08,440 --> 00:37:12,480
+بنك جديد ، إذا كنت لديكه ، يجب أن تشرح للمعارضة
+
+578
+00:37:12,480 --> 00:37:16,200
+أنك لديك موقع بنك جديد ، و كم المال الذي لديك فيه
+
+579
+00:37:16,200 --> 00:37:19,200
+و كم المال الذي لديك خارج هذا الموقع بنك الجديد ،
+
+580
+00:37:19,200 --> 00:37:22,720
+إنه كثير مشكلة ، إنه ليس بسهولة لأشخاص يكونوا
+
+581
+00:37:22,720 --> 00:37:26,400
+يتمون من الانفصال ، هل تريد أن تقول شيء؟it was
+
+582
+00:37:26,400 --> 00:37:31,960
+live ولا بس after؟
+
+583
+00:37:34,950 --> 00:37:38,250
+بسبب أنه لا يمكن .. لا يمكن .. ليس متأكد ولكن لا
+
+584
+00:37:38,250 --> 00:37:42,270
+يمكن يعني إذا كان في مغامرة بالطبع لن يكون قادر
+
+585
+00:37:42,270 --> 00:37:49,250
+بعد أن يصبح .. بعد أن كان لديه فرصة فرصة لرحيل لكن
+
+586
+00:37:49,250 --> 00:37:52,730
+تعتقد أن هذا .. هذا سيكون بسيط له؟ تعتقد أن الناس
+
+587
+00:37:52,730 --> 00:37:55,810
+ستثق به؟ لرحيل لالاختيار؟
+
+588
+00:38:04,370 --> 00:38:10,450
+Do you have any alternatives to bankruptcy؟
+
+589
+00:38:10,450 --> 00:38:15,270
+bankruptcy is the worst situation، bankruptcy is
+
+590
+00:38:15,270 --> 00:38:18,410
+something that is not acceptable by many people،
+
+591
+00:38:18,410 --> 00:38:21,990
+but then we have to look for alternatives، one of
+
+592
+00:38:21,990 --> 00:38:28,480
+them is called informal arrangementوالدتر و الـ
+
+593
+00:38:28,480 --> 00:38:32,840
+creditors يمكنهم أن يجلسوا و يتكلمون عن الحقيقة و
+
+594
+00:38:32,840 --> 00:38:35,740
+يستطيعون أن يحلوها بأي معنى ممكن يستطيعوا أن
+
+595
+00:38:35,740 --> 00:38:36,460
+يتكلموا عن الحقيقة بأي معنى ممكن يستطيعوا أن
+
+596
+00:38:36,460 --> 00:38:36,860
+يتكلموا عن الحقيقة بأي معنى ممكن يستطيعوا أن
+
+597
+00:38:36,860 --> 00:38:37,880
+يتكلموا عن الحقيقة بأي معنى ممكن يستطيعوا أن
+
+598
+00:38:37,880 --> 00:38:38,980
+يتكلموا عن الحقيقة بأي معنى ممكن يستطيعوا أن
+
+599
+00:38:38,980 --> 00:38:41,640
+تتكلموا عن الحقيقة بأي معنى ممكن يستطيعوا أن
+
+600
+00:38:41,640 --> 00:38:44,820
+تتكلموا عن الحقيقة بأي معنى ممكن يستطيعوا أن
+
+601
+00:38:44,820 --> 00:38:50,500
+تتكلموا عن الحقيقة بأي معنى ممكن
+
+602
+00:38:50,500 --> 00:38:56,090
+يستطيعوا أن تتكلموا عن الحقيوهو حسنًا، أحد يستطيع
+
+603
+00:38:56,090 --> 00:38:59,890
+أن يجلس مع قدراته ويقوم بتحل المشكلة، والثاني هو
+
+604
+00:38:59,890 --> 00:39:03,150
+IVA، لقد كان لدينا ذلك قبل، ولكن علينا أن نشرحه في
+
+605
+00:39:03,150 --> 00:39:07,010
+التفاصيل الآن IVA، Individual Voluntary
+
+606
+00:39:07,010 --> 00:39:13,510
+Arrangement، هذا .. هذا .. أميليكا؟ هذا مجرد تحديث
+
+607
+00:39:13,510 --> 00:39:17,830
+قبلًا، مجرد تحديث قبلًا، المدير يحتاج إلى أن يطبق
+
+608
+00:39:17,830 --> 00:39:21,530
+.. يحتاج إلى أن يطبق على الشاطرة بمساعدة Anne
+
+609
+00:39:21,530 --> 00:39:25,710
+Eiffelheiminsolvency practitioner he or she would
+
+610
+00:39:25,710 --> 00:39:30,350
+supervise the arrangement and pay the creditor in
+
+611
+00:39:30,350 --> 00:39:35,030
+line with the accepted proposal okay as you said
+
+612
+00:39:35,030 --> 00:39:38,030
+before that we have this arrangement can be made
+
+613
+00:39:38,030 --> 00:39:41,730
+between can be made between between the trustee
+
+614
+00:39:41,730 --> 00:39:46,310
+which is called insolvency practitioner andالدتر
+
+615
+00:39:46,310 --> 00:39:49,890
+يمكن أن يكون لديه خطة و هذه الخطة هي اقتراح يمكن
+
+616
+00:39:49,890 --> 00:39:52,470
+أن يحتوي على التالي يمكن أن يحتوي بالطبع على كل
+
+617
+00:39:52,470 --> 00:39:55,490
+المعلومات الاجتماعية بالإضافة إلى اقتراح
+
+618
+00:39:55,490 --> 00:40:00,050
+للمستخدمين يمكن أن يكون مبني على اعطاء هذا اعطاء
+
+619
+00:40:00,050 --> 00:40:07,930
+سيكون مبني على 75% من المال اذا اتفق اذا اتفق
+
+620
+00:40:07,930 --> 00:40:13,530
+الدتروإذا كنا نحصل على قيمة 75% من المال ففي هذه
+
+621
+00:40:13,530 --> 00:40:17,330
+الحالة نحصل على إقبال أخير من القيمين ونستطيع أن
+
+622
+00:40:17,330 --> 00:40:20,730
+نأخذ هذه التفكيرة إلى الحكومة لإيقافها
+
+623
+00:40:22,350 --> 00:40:27,770
+الان كما ترى هنا قيمة المقالات 75% من قيمة
+
+624
+00:40:27,770 --> 00:40:34,410
+المقالات وليس 75% من المستخدمين حتى لو كان لديك 10
+
+625
+00:40:34,410 --> 00:40:39,790
+مستخدمين و 2 منهم فقط 2 منهم يمتلكون قيمة المقالات
+
+626
+00:40:39,790 --> 00:40:47,320
+75% وفي هذه الحالة يجب أن نفضلهميجب أن يقبلونه بأي
+
+627
+00:40:47,320 --> 00:40:51,640
+مدفع أولي أو ثانوي على مقالات محددة يجب أن ندفعهم
+
+628
+00:40:51,640 --> 00:40:53,840
+على مقالات محددة في فترة محددة من الوقت يمكن أن
+
+629
+00:40:53,840 --> 00:40:57,980
+يكونين عامين أو خمس عامين وفي هذا البرنامج إذا
+
+630
+00:40:57,980 --> 00:41:02,280
+اقبلوا هذا البرنامج يجب أن نأخذه إلى الحكومة
+
+631
+00:41:02,280 --> 00:41:05,800
+لإعطائه لإقبله لإعطائه لإعطائه لإعطائه لإعطائه
+
+632
+00:41:05,800 --> 00:41:07,980
+لإعطائه لإعطائه لإعطائه لإعطائه لإعطائه لإعطائه
+
+633
+00:41:07,980 --> 00:41:10,520
+لإعطائه لإعطائه لإعطائه لإعطائه لإعطائه لإعطائه
+
+634
+00:41:10,520 --> 00:41:12,180
+لإعطائه لإ
+
+635
+00:41:15,260 --> 00:41:19,480
+يجب أن يكون مدفع للمستخدمين لإيقافهم حتى يكون
+
+636
+00:41:19,480 --> 00:41:24,400
+لديهم مدفع أخر مدفع مدفع مدفع مدفع مدفع مدفع مدفع
+
+637
+00:41:24,400 --> 00:41:26,460
+مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع
+
+638
+00:41:26,460 --> 00:41:27,040
+مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع
+
+639
+00:41:27,040 --> 00:41:27,160
+مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع
+
+640
+00:41:27,160 --> 00:41:33,500
+مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع
+
+641
+00:41:33,500 --> 00:41:38,540
+م
+
+642
+00:41:41,360 --> 00:41:45,060
+و في هذه التخطيطة أو هذه التخطيطة انت تقبلها او لا
+
+643
+00:41:45,060 --> 00:41:48,660
+انت تقبلها لا احد يستطيع أن يجعل المستخدمين
+
+644
+00:41:48,660 --> 00:41:51,280
+يقبلوها انت مستخدمك انت مستخدمك انت مستخدمك انت
+
+645
+00:41:51,280 --> 00:41:52,840
+مستخدمك انت مستخدمك انت مستخدمك انت مستخدمك انت
+
+646
+00:41:52,840 --> 00:41:53,360
+مستخدمك انت مستخدمك انت مستخدمك انت مستخدمك انت
+
+647
+00:41:53,360 --> 00:41:53,720
+مستخدمك انت مستخدمك انت مستخدمك انت مستخدمك انت
+
+648
+00:41:53,720 --> 00:41:54,120
+مستخدمك انت مستخدمك انت مستخدمك انت مستخدمك انت
+
+649
+00:41:54,120 --> 00:42:00,980
+مستخدمك انت مستخدمك انت مستخدمك انت مستخدمك انت
+
+650
+00:42:00,980 --> 00:42:04,060
+مستخدمك
+
+651
+00:42:04,060 --> 00:42:10,860
+انت
+
+652
+00:42:10,860 --> 00:42:19,100
+مثالثًا ، لدينا حرارة إدارة. كما قلت إذا كانت
+
+653
+00:42:19,100 --> 00:42:24,220
+المالية أقل من 5000 ريال ، وهو قيمة صغيرة في هذه
+
+654
+00:42:24,220 --> 00:42:28,200
+الحالة، فلا يوجد نقطة لأن يكون هناك مغامرة. ليس
+
+655
+00:42:28,200 --> 00:42:31,440
+صحيح لك أن تكون هناك مغامرة. ثم لدينا قرار صنعه من
+
+656
+00:42:31,440 --> 00:42:37,060
+الحكومة بمعاملاتالدفع يجب أن يتم تحقيقه بالدفع إلى
+
+657
+00:42:37,060 --> 00:42:42,220
+الحكومة و المستخدم سيأتي لتحقيق دفعه من الحكومة
+
+658
+00:42:42,220 --> 00:42:44,920
+حتى يحصل انه يحصل انه يحصل انه يحصل انه يحصل انه
+
+659
+00:42:44,920 --> 00:42:44,920
+يحصل انه يحصل انه يحصل انه يحصل انه يحصل انه يحصل
+
+660
+00:42:44,920 --> 00:42:45,260
+انه يحصل انه يحصل انه يحصل انه يحصل انه يحصل انه
+
+661
+00:42:45,260 --> 00:42:47,180
+يحصل انه يحصل انه يحصل انه يحصل انه يحصل انه يحصل
+
+662
+00:42:47,180 --> 00:42:49,400
+انه يحصل انه يحصل انه يحصل انه يحصل انه يحصل انه
+
+663
+00:42:49,400 --> 00:42:49,620
+يحصل انه يحصل انه يحصل انه يحصل انه يحصل انه يحصل
+
+664
+00:42:49,620 --> 00:42:57,480
+انه يحصل انه يحصل انه
+
+665
+00:42:59,230 --> 00:43:03,190
+الذي يجب أن يكون المال المطلوب من الحكومة التي
+
+666
+00:43:03,190 --> 00:43:09,370
+يمكن أن تكون حوالي 5000 فوائد وحتى
+
+667
+00:43:09,370 --> 00:43:14,570
+هذا المال 5 او 4 او ماذا ايه لا يوجد اهتمام انه او
+
+668
+00:43:14,570 --> 00:43:18,850
+انها لن يكون هناك اهتمام فوائد ولا اهتمام ولا
+
+669
+00:43:18,850 --> 00:43:21,150
+اهتمام ولا اهتمام ولا اهتمام ولا اهتمام ولا اهتمام
+
+670
+00:43:21,150 --> 00:43:21,150
+ولا اهتمام ولا اهتمام ولا اهتمام ولا اهتمام ولا
+
+671
+00:43:21,150 --> 00:43:21,190
+اهتمام ولا اهتمام ولا اهتمام ولا اهتمام ولا اهتمام
+
+672
+00:43:21,190 --> 00:43:21,690
+ولا اهتمام ولا اهتمام ولا اهتمام ولا اهتمام ولا
+
+673
+00:43:21,690 --> 00:43:22,390
+اهتمام ولا اهتمام ولا اهتمام ولا اهتمام ولا اهتمام
+
+674
+00:43:22,390 --> 00:43:26,510
+ولا اهتمام ولا اهتمام ولا اهتمام ولا اهتمام ولا
+
+675
+00:43:26,510 --> 00:43:30,710
+اههذه الأفعال يجب أن تتم إضافتها إلى المال التي
+
+676
+00:43:30,710 --> 00:43:38,530
+يجب أن تدفعه الدولة في وقت عام على مبادرة عامة كم
+
+677
+00:43:38,530 --> 00:43:42,830
+ساعة سيأخذ لكي تحصل على دستجراج؟ من تحرير الأسعار
+
+678
+00:43:42,830 --> 00:43:49,670
+إلى دستجراج كم ساعة سيأخذ؟ كم سنة؟ يمكن أن تأخذ
+
+679
+00:43:49,670 --> 00:43:52,730
+عامة واحد عامة كما قلت قبل في الولايات المتحدة
+
+680
+00:43:52,730 --> 00:43:58,820
+يمكن أن تأخذ عامة واحد عامةفي بعض الأحيان، هذا
+
+681
+00:43:58,820 --> 00:44:02,080
+الفرق أو هذا الوقت يمكن أن يتم استخدامه حتى 10
+
+682
+00:44:02,080 --> 00:44:06,940
+سنة، ربما أكتر أو أكتر، ببعض الأحيان، ببعض
+
+683
+00:44:06,940 --> 00:44:09,460
+الأحيان، كما يمكننا أن نرى هنا، هذا التجارب ليس
+
+684
+00:44:09,460 --> 00:44:13,280
+بالطبع اتماكي، ليس اتماكي يمكن أن يأخذ وقت، و يمكن
+
+685
+00:44:13,280 --> 00:44:16,800
+أن يأخذ هذا التجارب 1،2،3،4،5 سنة، يمكن أن يأخذ
+
+686
+00:44:16,800 --> 00:44:19,560
+وقت طويل، وحتى في بعض الأحيان، إذا كانوا يحصلوا
+
+687
+00:44:19,560 --> 00:44:23,960
+على هذا التجارب، يكون هناك بعض الخيارات مثل .. هل
+
+688
+00:44:23,960 --> 00:44:24,840
+تستطيع أن تقرأ؟
+
+689
+00:44:27,470 --> 00:44:28,350
+إن كان هناك مخاطر، إذا كان هناك مخاطر، إذا كان
+
+690
+00:44:28,350 --> 00:44:31,830
+هناك مخاطر، إذا كان هناك مخاطر, إذا كان هناك
+
+691
+00:44:31,830 --> 00:44:32,650
+مخاطر, إذا كان هناك مخاطر, إذا كان هناك مخاطر, إذا
+
+692
+00:44:32,650 --> 00:44:32,650
+كان هناك مخاطر, إذا كان هناك مخاطر, إذا كان هناك
+
+693
+00:44:32,650 --> 00:44:32,930
+مخاطر, إذا كان هناك مخاطر, إذا كان هناك مخاطر, إذا
+
+694
+00:44:32,930 --> 00:44:34,370
+كان هناك مخاطر, إذا كان هناك مخاطر, إذا كان هناك
+
+695
+00:44:34,370 --> 00:44:36,150
+مخاطر, إذا كان هناك مخاطر, إذا كان هناك مخاطر, إذا
+
+696
+00:44:36,150 --> 00:44:37,210
+كان هناك مخاطر, إذا كان هناك مخاطر, إذا كان هناك
+
+697
+00:44:37,210 --> 00:44:45,130
+مخاطر, إذا كان هناك مخاطر, إذا كان هناك
+
+698
+00:44:45,130 --> 00:44:49,810
+مخاطر, إذا كان هناوحتى لو كان لدينا اختيار لذلك
+
+699
+00:44:49,810 --> 00:44:53,790
+الشخص، فهناك اختيارات في الواقع انه او هي لن يكون
+
+700
+00:44:53,790 --> 00:44:57,070
+اختيار، لن يكون حر، يجب أن يكون مثل هذا، خاصة لو
+
+701
+00:44:57,070 --> 00:44:58,150
+كان لدينا عملية عملية عملية عملية عملية عملية
+
+702
+00:44:58,150 --> 00:45:01,810
+عملية عملية عملية عملية عملية
+
+703
+00:45:01,810 --> 00:45:01,950
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+704
+00:45:01,950 --> 00:45:02,270
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+705
+00:45:02,270 --> 00:45:02,770
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+706
+00:45:02,770 --> 00:45:05,710
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+707
+00:45:05,710 --> 00:45:11,850
+عملية عملية عملية عملية عملية عملية عملية عمل
+
+708
+00:45:12,300 --> 00:45:16,380
+لدينا اتفاق الثاني اذا لم يكن اتفاق الاول اتفاق
+
+709
+00:45:16,380 --> 00:45:18,040
+الثاني اذا لم يكن اتفاق الاول اتفاق الثاني اذا لم
+
+710
+00:45:18,040 --> 00:45:18,420
+يكن اتفاق الاول اتفاق الاول اتفاق الاول اتفاق
+
+711
+00:45:18,420 --> 00:45:20,960
+الاول اتفاق الاول اتفاق الاول اتفاق الاول اتفاق
+
+712
+00:45:20,960 --> 00:45:24,980
+الاول اتفاق الاول اتفاق الاول اتفاق الاول اتفاق
+
+713
+00:45:24,980 --> 00:45:25,660
+الاول اتفاق الاول اتفاق الاول اتفاق الاول اتفاق
+
+714
+00:45:25,660 --> 00:45:26,300
+الاول اتفاق الاول اتفاق الاول اتفاق الاول اتفاق
+
+715
+00:45:26,300 --> 00:45:34,260
+الاول اتفاق الاول اتفاق الاول اتفاق
+
+716
+00:45:34,260 --> 00:45:41,460
+الاول
+
+717
+00:45:41,460 --> 00:45:48,570
+اتفاوهذا الوقت يمكن أن يكون 8 أو 10 سنة إذا كان
+
+718
+00:45:48,570 --> 00:45:52,430
+يقوم بالخطاب إذا كان يخاطب الناس إذا كان يخاطب
+
+719
+00:45:52,430 --> 00:45:57,030
+الشرطة إذا لم يتعمل معها إذا كان المال كثير إذا
+
+720
+00:45:57,030 --> 00:46:00,090
+وإذا كان لديه الكثير من الأسباب التي يمكن أن يقرر
+
+721
+00:46:00,090 --> 00:46:06,050
+الشرطة أن تعطي هذا الشخص هذا الشرطة أو لا مرة
+
+722
+00:46:06,050 --> 00:46:09,670
+أخرى هذه ستجعلنا نفس المسألة التي كنت أقولها إذا
+
+723
+00:46:09,670 --> 00:46:17,880
+كان نفس الشخص مغامرمثلًا قبل هنا مثلًا هنا لدينا
+
+724
+00:46:17,880 --> 00:46:22,940
+تجارب و لدينا تجارب و بعد تجارب تجارب إذا كنت ترغب
+
+725
+00:46:22,940 --> 00:46:26,960
+أن تعود للعمل، يمكنك أن تكون لديك حياتك جديدة،
+
+726
+00:46:26,960 --> 00:46:30,160
+ولكن لديك بعض الانقلابات، لن تكون لديك الحرية،
+
+727
+00:46:30,160 --> 00:46:34,360
+ولكن عندما يمكنك أن تطبق هنا، يمكنك أن تطبق هنا،
+
+728
+00:46:34,360 --> 00:46:37,500
+لكي تكون مسموحًا لكي تعود لعمل، لعمل، يمكنك فعل
+
+729
+00:46:37,500 --> 00:46:41,310
+ذلكهذا يمكن ان يكون بعد 1 عام او 10 عام او 15 عام
+
+730
+00:46:41,310 --> 00:46:41,590
+او 15 عام او 15 عام او 15 عام او 15 عام او 15 عام
+
+731
+00:46:41,590 --> 00:46:41,990
+او 15 عام او 15 عام او 15 عام او 15 عام او 15 عام
+
+732
+00:46:41,990 --> 00:46:43,770
+او 15 عام او 15 عام او 15 عام او 15 عام او 15 عام
+
+733
+00:46:43,770 --> 00:46:45,750
+او 15 عام او 15 عام او 15 عام او 15 عام او 15 عام
+
+734
+00:46:45,750 --> 00:46:48,330
+او 15 عام او 15 عام او 15 عام او 15 عام او 15 عام
+
+735
+00:46:48,330 --> 00:46:48,390
+او 15 عام او 15 عام او 15 عام او 15 عام او 15 عام
+
+736
+00:46:48,390 --> 00:46:48,450
+او 15 عام او 15 عام او 15 عام او 15 عام او 15 عام
+
+737
+00:46:48,450 --> 00:46:54,570
+او 15 عام او 15 عام او 15 عام او 15 عام او 15 عام
+
+738
+00:46:54,570 --> 00:47:02,490
+او 15هو يصبح مغامرًا. المشكلة اللي نتعامل معها هنا
+
+739
+00:47:02,490 --> 00:47:08,170
+هي أنه لم يكن لديه مهمة بعد ذلك وانه ذهب للعمل
+
+740
+00:47:08,170 --> 00:47:13,170
+بدون إخبار المؤمنين وكان مغامرًا للثانوية مرة.
+
+741
+00:47:14,710 --> 00:47:18,990
+الاختلافات ستكون عظيمة. لربما لا يكون لديه مهمة في
+
+742
+00:47:18,990 --> 00:47:24,900
+المستقبل وربما يكون مجرمًاهو قد يكون في الحجز،
+
+743
+00:47:24,900 --> 00:47:29,480
+لدينا اتفاقات جديدة، آخر صفحة اللي لدينا هي، وهي
+
+744
+00:47:29,480 --> 00:47:34,520
+حقا مهمة، هل يمكن أن يكون التجارب عددها؟ هل نستطيع
+
+745
+00:47:34,520 --> 00:47:37,420
+أن نتخلص من التجارب؟ عندما يكون لدينا قرار مجرد
+
+746
+00:47:37,420 --> 00:47:44,120
+قرار مجرد قرار مجرد قرار مجرد قرار مجرد قرار مجرد
+
+747
+00:47:44,120 --> 00:47:44,540
+قرار مجرد قرار مجرد قرار مجرد قرار مجرد قرار مجرد
+
+748
+00:47:44,540 --> 00:47:44,580
+قرار مجرد قرار مجرد قرار مجرد قرار مجرد قرار مجرد
+
+749
+00:47:44,580 --> 00:47:48,060
+قرار مجرد قرار مجرد قرار مجرد
+
+750
+00:47:48,060 --> 00:47:52,700
+قرار م
+
+751
+00:47:53,270 --> 00:47:59,830
+هل نعيدها؟ نعم، كيف؟ لدينا ثلاثة أسلوب، كيف
+
+752
+00:47:59,830 --> 00:48:04,070
+نعيدها؟
+
+753
+00:48:04,070 --> 00:48:09,910
+الشخص
+
+754
+00:48:09,910 --> 00:48:11,810
+اللي يمكن أن يتعامل مع الشخص اللي يتعامل مع الشخص
+
+755
+00:48:11,810 --> 00:48:12,450
+اللي يتعامل مع الشخص اللي يتعامل مع الشخص اللي
+
+756
+00:48:12,450 --> 00:48:13,330
+يتعامل مع الشخص اللي يتعامل مع الشخص اللي يتعامل
+
+757
+00:48:13,330 --> 00:48:13,750
+مع الشخص اللي يتعامل مع الشخص اللي يتعامل مع الشخص
+
+758
+00:48:13,750 --> 00:48:15,870
+اللي يتعامل مع الشخص اللي يتعامل مع الشخص اللي
+
+759
+00:48:15,870 --> 00:48:15,930
+يتعامل مع الشخص اللي يتعامل مع الشخص اللي يتعامل
+
+760
+00:48:15,930 --> 00:48:16,430
+مع الشخص اللي يتعامل مع الشخص اللي يتعامل مع الشخص
+
+761
+00:48:16,430 --> 00:48:16,770
+اللي يتعامل مع
+
+762
+00:48:23,900 --> 00:48:29,780
+Okay number one if there was a mistake in the
+
+763
+00:48:29,780 --> 00:48:33,460
+proceduresإذا كان هناك خطأ كان هناك خطوات كانوا
+
+764
+00:48:33,460 --> 00:48:36,460
+يقومون بها خطوات خطوات كانوا يقومون بها خطوات
+
+765
+00:48:36,460 --> 00:48:39,460
+خطوات خطوات خطوات خطوات خطوات خطوات خطوات خطوات
+
+766
+00:48:39,460 --> 00:48:39,460
+خطوات خطوات خطوات خطوات خطوات خطوات خطوات خطوات
+
+767
+00:48:39,460 --> 00:48:42,180
+خطوات خطوات خطوات خطوات خطوات خطوات خطوات خطوات
+
+768
+00:48:42,180 --> 00:48:42,260
+خطوات خطوات خطوات خطوات خطوات خطوات خطوات خطوات
+
+769
+00:48:42,260 --> 00:48:43,100
+خطوات خطوات خطوات خطوات خطوات خطوات خطوات خطوات
+
+770
+00:48:43,100 --> 00:48:47,140
+خطوات خطوات خطوات خطوات خطوات خ
+
+771
+00:49:00,230 --> 00:49:06,310
+إذا كانت المالكة قد قبلت كمية المال كمية كمية كمية
+
+772
+00:49:06,310 --> 00:49:07,050
+كمية كمية كمية كمية كمية كمية كمية كمية كمية كمية
+
+773
+00:49:07,050 --> 00:49:09,410
+كمية كمية كمية كمية كمية كمية كمية كمية كمية كمية
+
+774
+00:49:09,410 --> 00:49:13,610
+كمية كمية كمية كمية كمية كمية كمية كمية كمية كمية
+
+775
+00:49:13,610 --> 00:49:14,510
+كمية كمية كمية كمية كمية كمية كمية
+
+776
+00:49:27,520 --> 00:49:31,600
+بإمكاننا أن نتفاهم هنا بشكل صحيح بأن الانفجار
+
+777
+00:49:31,600 --> 00:49:35,580
+سيدفع الكثير من المال. نستطيع أن نتخلص من قرار
+
+778
+00:49:35,580 --> 00:49:40,040
+الانفجار ونستطيع أن نتحرك إلى شيء يسمى IVA، وهو
+
+779
+00:49:40,040 --> 00:49:47,340
+هنا في IVA، يجب أن يتم الانفجار قبل أن يكون هناك
+
+780
+00:49:47,340 --> 00:49:54,700
+انفجارعادةً الـ IVA هي مجلة ممنعية ممنعية ويقائية
+
+781
+00:49:54,700 --> 00:49:56,540
+هذه الانتجارة الانتجارية الانتجارية الانتجارية
+
+782
+00:49:56,540 --> 00:49:58,100
+الانتجارية الانتجارية الانتجارية الانتجارية
+
+783
+00:49:58,100 --> 00:50:01,360
+الانتجارية الانتجارية الانتجارية الانتجارية
+
+784
+00:50:01,360 --> 00:50:02,440
+الانتجارية الانتجارية الانتجارية الانتجارية
+
+785
+00:50:02,440 --> 00:50:02,820
+الانتجارية الانتجارية الانتجارية الانتجارية
+
+786
+00:50:02,820 --> 00:50:02,920
+الانتجارية الانتجارية الانتجارية الانتجارية
+
+787
+00:50:02,920 --> 00:50:05,680
+الانتجارية الانتجارية الانتجارية الانتجارية
+
+788
+00:50:05,680 --> 00:50:11,900
+الانتجارية الانتجارية الانتجارية الانتجارية
+
+789
+00:50:11,900 --> 00:50:12,720
+الانتجارية
+
+790
+00:50:15,680 --> 00:50:19,680
+الدترا قام و ال bankrupt قام و قال انا سأكون قيمة
+
+791
+00:50:19,680 --> 00:50:23,160
+المال انا لدي بعض المقارنات انا لدي بعض المشاركات
+
+792
+00:50:23,160 --> 00:50:27,400
+اعطيني بعض الوقت ثم نستطيع ان نطبق ال IV هذا يمكن
+
+793
+00:50:27,400 --> 00:50:29,600
+ان يكون قاسي يمكن ان يكون صعب يمكن ان يأخذ المزيد
+
+794
+00:50:29,600 --> 00:50:33,820
+من الوقت لأنه مصطلح بعد اتصال ال bankrupt لانه
+
+795
+00:50:33,820 --> 00:50:36,820
+يمكن ان يكون مشكلة جدا لان المال كذلك لقد أخذنا
+
+796
+00:50:36,820 --> 00:50:40,740
+المال منه و دفعناه بين الكثير من الناس الكثير من
+
+797
+00:50:40,740 --> 00:50:44,610
+المعارفينالان يجب أن ننظر مرة أخرى في نفس المقارنة
+
+798
+00:50:44,610 --> 00:50:48,030
+كم مال ندفعه كم يمكننا أن نعود كم يمكننا أن نعود
+
+799
+00:50:48,030 --> 00:50:48,710
+كم يمكننا أن نعود كم يمكننا أن نعود كم يمكننا أن
+
+800
+00:50:48,710 --> 00:50:49,690
+نعود كم يمكننا أن نعود كم يمكننا أن نعود كم يمكننا
+
+801
+00:50:49,690 --> 00:50:52,310
+أن نعود كم يمكننا أن نعود كم يمكننا أن نعود كم
+
+802
+00:50:52,310 --> 00:50:53,350
+يمكننا أن نعود كم يمكننا أن نعود كم يمكننا أن نعود
+
+803
+00:50:53,350 --> 00:50:55,790
+كم يمكننا أن نعود كم يمكننا أن نعود كم يمكننا أن
+
+804
+00:50:55,790 --> 00:50:56,350
+نعود كم يمكننا أن نعود كم يمكننا أن نعود كم يمكننا
+
+805
+00:50:56,350 --> 00:51:07,310
+أن نعود كم يمكننا أن نعود كم يمكننا أن نعود كم
+
+806
+00:51:07,310 --> 00:51:12,000
+يHello everybody, I want to talk mortgage business
+
+807
+00:51:12,000 --> 00:51:16,440
+.Mortgage contract is contract right to arrange my
+
+808
+00:51:16,440 --> 00:51:20,480
+eyes on something security for debt and trade law,
+
+809
+00:51:20,860 --> 00:51:23,900
+not as commercial mortgage contract as contract
+
+810
+00:51:23,900 --> 00:51:27,160
+right to arrange security for debt moved business.
+
+811
+00:51:27,820 --> 00:51:32,160
+هذا يعني أنه يوجد مرتجز مجتمع عن البروبيرتي التي
+
+812
+00:51:32,160 --> 00:51:36,760
+يجب أن تكون متحركة ويجب أن تجد دائما أن هناك حكومة
+
+813
+00:51:36,760 --> 00:51:43,400
+حقيقية تدفع بروبيرتي مع اتصال إلى طريق المال للدفع
+
+814
+00:51:43,400 --> 00:51:50,590
+للدفع والدفع يتم حفظه من بروبيرتيهذا التقرير مجتمع
+
+815
+00:51:50,590 --> 00:51:57,270
+مخصص، ولكنه أهم من ذلك هو ليس فقط فكرة تدفع حملة
+
+816
+00:51:57,270 --> 00:52:02,450
+حقيقية بطاقة استثمارية من نفس البروبرتي، ولكنه
+
+817
+00:52:02,450 --> 00:52:08,090
+مرتبط بالأمانات والشركات هي شركات تدفع حملة بطاقة
+
+818
+00:52:08,090 --> 00:52:14,050
+الشخصيةtransferring maybe material or moral but at
+
+819
+00:52:14,050 --> 00:52:18,090
+least that was the moral requirement to be
+
+820
+00:52:18,090 --> 00:52:22,670
+constant as negateable instruments so they can
+
+821
+00:52:22,670 --> 00:52:30,240
+reply to him that the mortgage businessوهو مقرر من
+
+822
+00:52:30,240 --> 00:52:38,480
+شركة موردجاش بلدجت دبت لدبتور عندما يكون موردجاش
+
+823
+00:52:38,480 --> 00:52:43,100
+مجتمع لدبتور ثم موردجاش مجتمع .. موردجاش مجتمع هو
+
+824
+00:52:43,100 --> 00:52:49,420
+خلق دبت مجتمع ثم عندما كان هناك دبت مجتمع وموردجاش
+
+825
+00:52:49,420 --> 00:52:54,320
+مجتمع قرر أن يكون موردجاش مجتمع بدون أنقص على شيء
+
+826
+00:52:54,320 --> 00:53:00,070
+آخرالتعامل الموردجيشي استمر بسبب أنه لا يمكن أن
+
+827
+00:53:00,070 --> 00:53:04,990
+يعمل موضوع مستقل يجب أن يكونوا مقررين أن يتأكدوا
+
+828
+00:53:04,990 --> 00:53:09,890
+أن الدين هو مصطلح الأطفال الأصليين مصطلح
+
+829
+00:53:09,890 --> 00:53:16,630
+الموردجيشي هو مصطلحه ومكانه هو التعامل الموردجيشي
+
+830
+00:53:16,630 --> 00:53:18,430
+بتعامل التعامل الموردجيشي بتعامل التعامل التعامل
+
+831
+00:53:18,430 --> 00:53:24,110
+الموردجيشي بتعامل التعامل الموردجيشيموردجاج مستخدم
+
+832
+00:53:24,110 --> 00:53:29,110
+لتحقيق موردجاجات موردجاجات مستخدم لتحقيق موردجاجات
+
+833
+00:53:29,110 --> 00:53:30,850
+مستخدم لتحقيق موردجاجات مستخدم لتحقيق موردجاجات
+
+834
+00:53:30,850 --> 00:53:32,110
+مستخدم لتحقيق موردجاجات مستخدم لتحقيق موردجاجات
+
+835
+00:53:32,110 --> 00:53:33,210
+مستخدم لتحقيق موردجاجات مستخدم لتحقيق موردجاجات
+
+836
+00:53:33,210 --> 00:53:33,430
+مستخدم لتحقيق موردجاجات مستخدم لتحقيق موردجاجات
+
+837
+00:53:33,430 --> 00:53:37,350
+مستخدم لتحقيق موردجاجات مستخدم لتحقيق موردجاجات
+
+838
+00:53:37,350 --> 00:53:44,330
+مستخدم لتحقيق موردجاجات
+
+839
+00:53:44,330 --> 00:53:47,670
+مستخدم لتحقيق موردجاجات مستخ
+
+840
+00:53:49,940 --> 00:53:58,580
+هو ربما للشخص الذاتي وشخص آخر يقدم، ونجد أيضًا أن
+
+841
+00:53:58,580 --> 00:54:06,140
+أكثر الشخص يمكن أن يأتي ويحمي الشيء، يقدم، وشخص
+
+842
+00:54:06,140 --> 00:54:14,900
+آخر يملك الشخصكيف تنتهي التقرير مورتغيش تقرر
+
+843
+00:54:14,900 --> 00:54:21,920
+بصراحة وإقبال لا يجب أن يكتب إنه لا يثبت أو يتجارب
+
+844
+00:54:21,920 --> 00:54:29,210
+في وجه الآخر هناك إختلافالاستثمار في مصالح الحقوق
+
+845
+00:54:29,210 --> 00:54:34,450
+اللازمة من المسلحين عندما المسلحين يدفعوا نقطة أو
+
+846
+00:54:34,450 --> 00:54:39,070
+مسلحين أخرى للتعامل مع بعضهم بمجال التعامل مع
+
+847
+00:54:39,070 --> 00:54:40,930
+بعضهم بمجال التعامل مع بعضهم بمجال التعامل مع
+
+848
+00:54:40,930 --> 00:54:42,090
+بعضهم بمجال التعامل مع بعضهم بمجال التعامل مع
+
+849
+00:54:42,090 --> 00:54:42,090
+بعضهم بمجال التعامل مع بعضهم بمجال التعامل مع
+
+850
+00:54:42,090 --> 00:54:43,270
+بعضهم بمجل التعامل مع بعضهم بمجل التعامل مع بعضهم
+
+851
+00:54:43,270 --> 00:54:44,250
+بمجل التتعامل مع بعضهم بمجل التتعامل مع بعضهم بمجل
+
+852
+00:54:44,250 --> 00:54:45,490
+التتعامل مع بعضهم بمجل التتعامل مع بعضهم بمجل
+
+853
+00:54:45,490 --> 00:54:49,710
+التتععندما يكون المعاملة مقررة في المسلحة لتكون
+
+854
+00:54:49,710 --> 00:54:57,250
+شكل مدرسة في حالة المسلحة ولكن إذا كانت اسمها يجب
+
+855
+00:54:57,250 --> 00:55:02,350
+أن تكون مدير ويأخذ حركة، وهو عادة مستقبل في كتب
+
+856
+00:55:02,350 --> 00:55:07,970
+المسلحة التي تم إتجارها، يكونوا مضطرين إلى المسلحة
+
+857
+00:55:07,970 --> 00:55:10,250
+التي يتم إتجارها في المسلحة التي يتم إتجارها في
+
+858
+00:55:10,250 --> 00:55:11,050
+المسلحة التي يتم إتجارها في المسلحة التي يتم
+
+859
+00:55:11,050 --> 00:55:13,510
+إتجارها في المسلحة التي يتم إتجارها في المسلحة
+
+860
+00:55:13,510 --> 00:55:15,150
+التي يتم إتجارها في المسلحة التي يتم إتجارها في
+
+861
+00:55:15,150 --> 00:55:15,390
+المسلحة التي يتم إتجارها في المسلحة التي يتم إتج
+
+862
+00:55:16,780 --> 00:55:21,320
+ماهي اهتمام الـ Mortgage؟ الـ Resulting Mortgage
+
+863
+00:55:21,320 --> 00:55:25,860
+possesory two rights. One right in solitary thing.
+
+864
+00:55:26,260 --> 00:55:30,960
+B right of proprietary in obtaining the loan
+
+865
+00:55:30,960 --> 00:55:34,540
+amount and recovery of the price of the mortgaged
+
+866
+00:55:34,540 --> 00:55:40,770
+and legislature.بالنسبة لهذه الاثنين الأفكار قالوا
+
+867
+00:55:40,770 --> 00:55:46,110
+إنهم لا يتجاربوا نفسهم في الجزء الثالث إلا إذا
+
+868
+00:55:46,110 --> 00:55:52,710
+كانت التغيير من بوثشان إلى موردجاجي وليس فقط كذلك،
+
+869
+00:55:52,710 --> 00:55:57,810
+ولكن ما كان موردجاجي في بوثشان من موردجاجي هو طول
+
+870
+00:55:57,810 --> 00:56:04,010
+الموردجاجon the transfer of position. position the
+
+871
+00:56:04,010 --> 00:56:07,790
+character and mortgage is the number of images
+
+872
+00:56:10,980 --> 00:56:16,480
+وانتقل إلى موقف الحقيقي وانتقل إلى موقف الوطن الذي
+
+873
+00:56:16,480 --> 00:56:21,660
+يتطلب استخدام المساعدة أو
+
+874
+00:56:21,660 --> 00:56:26,860
+فقط تأخذ موقف الوطن الذي يتطلب استخدام المساعدة
+
+875
+00:56:26,860 --> 00:56:30,180
+وانتقل إلى موقف الوطن الذي يتطلب استخدام المساعدة
+
+876
+00:56:30,180 --> 00:56:30,640
+أو انتقل إلى موقف الوطن اللي يتطلب استخدام
+
+877
+00:56:30,640 --> 00:56:32,820
+المساعدة أو انتقل إلى موقف الوطن اللي يتطلب
+
+878
+00:56:32,820 --> 00:56:34,380
+استخدام المساعدة أو انتقل إلى موقف الوطن اللي
+
+879
+00:56:34,380 --> 00:56:36,160
+يتطلب استخدام المساعدة أو انتقل إلى موقف الوطن
+
+880
+00:56:36,160 --> 00:56:39,560
+اللي يتطلب استخدام المساعدة أو انتقل إلى موقف
+
+881
+00:56:39,560 --> 00:56:39,600
+الوطن اللي يتط
+
+882
+00:57:01,390 --> 00:57:04,530
+وهو تحويل المصادر
+
+883
+00:57:06,940 --> 00:57:13,320
+إذا كانت الشيء الصحيح أن يتحرر أو يتخلص، كانت
+
+884
+00:57:13,320 --> 00:57:16,880
+الشيء الصحيح أن يتحرر أو يتخلص، كانت حق الكريدور
+
+885
+00:57:16,880 --> 00:57:22,600
+أن يطلب من الشيطان أن يقوم بتفصيلها، وكذلك، الشيء
+
+886
+00:57:22,600 --> 00:57:27,980
+سيدخل في حركة الكريدور، ويخلق على رأسه عمليات
+
+887
+00:57:27,980 --> 00:57:31,860
+عديدة، وعندما كان الشيطان يحرر الشيطان، وعندما
+
+888
+00:57:31,860 --> 00:57:37,310
+يحصل على الشيطان،استخدام مصطلح الموردجيش مصطلح
+
+889
+00:57:37,310 --> 00:57:41,810
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+890
+00:57:41,810 --> 00:57:47,470
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+891
+00:57:47,470 --> 00:57:47,590
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+892
+00:57:47,590 --> 00:57:47,670
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+893
+00:57:47,670 --> 00:57:53,050
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+894
+00:57:53,050 --> 00:57:57,510
+مصط
+
+895
+00:57:59,170 --> 00:58:03,430
+حسنًا، سنتحدث عن جزء صحيح من الـ e-commerce قبل
+
+896
+00:58:03,430 --> 00:58:08,470
+ذلك، سنسأل أسئلة واحدة وهي، هل مجتمع الإنترنت ممكن
+
+897
+00:58:08,470 --> 00:58:14,710
+تحميله؟ في عملياتنا، نحصل عادة على أسئلة عن ممكنة
+
+898
+00:58:14,710 --> 00:58:21,610
+تحميل مجتمع الإنترنت ممكن تحميل مجتمع الإنترنت
+
+899
+00:58:21,610 --> 00:58:22,550
+ممكن تحميل مجتمع الإنترنت ممكن تحميل مجتمع
+
+900
+00:58:22,550 --> 00:58:24,670
+الإنترنت ممكن تحميل مجتمع الإنترنت ممكن تحميل
+
+901
+00:58:24,670 --> 00:58:26,930
+مجتمع الإنترنت ممكن تحميل مجتمع الإنترنت ممكن
+
+902
+00:58:26,930 --> 00:58:27,090
+تحميل مجتمع الإنترنت ممكن تحميل مجتمع الإنترنت
+
+903
+00:58:27,090 --> 00:58:28,750
+ممكن تحميل مجتمع الإنترنت ممكنأما إذا كانت
+
+904
+00:58:28,750 --> 00:58:32,230
+المشاركة تتم تصميمها من جمهور الشركات على الإنترنت
+
+905
+00:58:32,230 --> 00:58:39,170
+أو من إجراء مقالات مكتوبة على الإنترنت أو
+
+906
+00:58:39,170 --> 00:58:39,510
+على الإنترنت أو على الإنترنت أو على الإنترنت أو
+
+907
+00:58:39,510 --> 00:58:39,510
+على الإنترنت أو على الإنترنت أو على الإنترنت أو
+
+908
+00:58:39,510 --> 00:58:39,610
+على الإنترنت أو على الإنترنت أو على الإنترنت أو
+
+909
+00:58:39,610 --> 00:58:39,970
+على الإنترنت أو على الإنترنت أو على الإنترنت أو
+
+910
+00:58:39,970 --> 00:58:41,130
+على الإنترنت أو على الإنترنت أو على الإنترنت أو
+
+911
+00:58:41,130 --> 00:58:44,330
+على الإنترنت أو على الإنترنت أو على الإنترنت أو
+
+912
+00:58:44,330 --> 00:58:45,490
+على الإنترنت أو على الإنترنت أو على الإنترنت أو
+
+913
+00:58:45,490 --> 00:58:46,730
+على الإنترнет أو على الإنترнет أو على الإنترнет أو
+
+914
+00:58:46,730 --> 00:58:49,490
+على الإنترнет أو على الإنترнет أو على الإنترнет أو
+
+915
+00:58:49,490 --> 00:58:52,550
+على الإنترнет أو على الإينتUnderstanding
+
+916
+00:58:52,550 --> 00:58:57,490
+Electronic Data Interchange Building and Managing
+
+917
+00:58:57,490 --> 00:59:01,090
+a Virtual Team Product Development Developing Your
+
+918
+00:59:01,090 --> 00:59:04,950
+Online Store Online Transactions Etc Online
+
+919
+00:59:04,950 --> 00:59:07,730
+Marketing and Monitoring Your Websites and Other
+
+920
+00:59:07,730 --> 00:59:12,620
+General Resourcesالثانية E-Commerce وقانونها E
+
+921
+00:59:12,620 --> 00:59:15,380
+-Commerce وقانونها E-Commerce وقانونها E-Commerce
+
+922
+00:59:15,380 --> 00:59:20,860
+وقانونها E-Commerce وقانونها E-Commerce وقانونها E
+
+923
+00:59:20,860 --> 00:59:23,120
+-Commerce وقانونها E-Commerce وقانونها E-Commerce
+
+924
+00:59:23,120 --> 00:59:23,120
+وقانونها E-Commerce وقانونها E-Commerce وقانونها E
+
+925
+00:59:23,120 --> 00:59:23,120
+-Commerce وقانونها E-Commerce وقانونها E-Commerce
+
+926
+00:59:23,120 --> 00:59:26,940
+وقانونها E-Commerce وقانونها E-Commerce وقانونها E
+
+927
+00:59:26,940 --> 00:59:28,420
+-Commerce وقانونها E-Commerce وقانونها E-Commerce
+
+928
+00:59:28,420 --> 00:59:30,200
+وقانونها E-Commerce وقانونها E-Commerce وقانونها E
+
+929
+00:59:30,200 --> 00:59:31,560
+-Commerce وقانونها E-Commerce وقانونها E-Commerce
+
+930
+00:59:31,560 --> 00:59:37,160
+وقانونها E
+
+931
+00:59:37,160 --> 00:59:43,080
+-CommerceA commerce and tax law journal, a legal
+
+932
+00:59:43,080 --> 00:59:45,260
+publication recreated and published by the
+
+933
+00:59:45,260 --> 00:59:48,800
+internet business law services ILBS, the world's
+
+934
+00:59:48,800 --> 00:59:52,220
+largest interest law publisher and Thomas
+
+935
+00:59:52,220 --> 00:59:56,120
+Jefferson school of law master's in law program,
+
+936
+00:59:56,680 --> 01:00:00,440
+the law journal published writing by academics
+
+937
+01:00:03,110 --> 01:00:06,990
+التعاملين والمصادر على مجموعة من المواضيع بما
+
+938
+01:00:06,990 --> 01:00:08,990
+يتعلق بـ E-Commerce Electronic Contracting
+
+939
+01:00:08,990 --> 01:00:13,570
+Technotorts Cybercrime Privacy Internet Taxation
+
+940
+01:00:13,570 --> 01:00:16,790
+International Taxation وكذلك التعامل الإلكتروني
+
+941
+01:00:16,790 --> 01:00:22,110
+الانترنتي الانترنتي
+
+942
+01:00:22,110 --> 01:00:26,030
+الانترنتي الانترنتي الانترنتيمجلد يتطور ويقوم
+
+943
+01:00:26,030 --> 01:00:29,910
+بإنجاز أسهل ومساعدة ومساعدة ومساعدة ومساعدة
+
+944
+01:00:29,910 --> 01:00:30,750
+ومساعدة ومساعدة ومساعدة ومساعدة ومساعدة ومساعدة
+
+945
+01:00:30,750 --> 01:00:34,110
+ومساعدة ومساعدة ومساعدة ومساعدة ومساعدة ومساعدة
+
+946
+01:00:34,110 --> 01:00:34,450
+ومساعدة ومساعدة ومساعدة ومساعدة ومساعدة ومساعدة
+
+947
+01:00:34,450 --> 01:00:35,230
+ومساعدة ومساعدة ومساعدة ومساعدة ومساعدة ومساعدة
+
+948
+01:00:35,230 --> 01:00:44,010
+ومساعدة ومساعدة ومساعدة ومساعدة ومساعدة
+
+949
+01:00:44,010 --> 01:00:47,830
+ومساعد
+
+950
+01:00:47,850 --> 01:00:52,010
+مجموعة العمل، مجموعة العمل على التدخل في المصادر
+
+951
+01:00:52,010 --> 01:00:53,530
+الإلكترونية ومجموعة العمل على التدخل في المصادر
+
+952
+01:00:53,530 --> 01:00:55,450
+الإلكترونية ومجموعة العمل على التدخل في المصادر
+
+953
+01:00:55,450 --> 01:00:56,490
+الإلكترونية ومجموعة العمل على التدخل في المصادر
+
+954
+01:00:56,490 --> 01:00:57,550
+الإلكترونية ومجموعة العمل على التدخل في المصادر
+
+955
+01:00:57,550 --> 01:00:59,570
+الإلكترونية ومجموعة العمل على التدخل في المصادر
+
+956
+01:00:59,570 --> 01:01:00,130
+الإلكترونية ومجموعة العمل على التدخل في المصادر
+
+957
+01:01:00,130 --> 01:01:00,550
+الإلكترونية ومجموعة العمل على التدخل في المصادر
+
+958
+01:01:00,550 --> 01:01:01,510
+الإلكترونية ومجموعة العمل على التدخل في المصادر
+
+959
+01:01:01,510 --> 01:01:05,800
+الإلكترونية وهو الشركة الأساسية الفيدرالية التي
+
+960
+01:01:05,800 --> 01:01:07,980
+تسيطر على المشاركات الإجتماعية الإجتماعية، يتضمن
+
+961
+01:01:07,980 --> 01:01:11,400
+استخدام إتصالات مجتمعية، إتصالات مجتمعية، إتصالات
+
+962
+01:01:11,400 --> 01:01:12,520
+مجتمعية، إتصالات مجتمعية، إتصالات مجتمعية، إتصالات
+
+963
+01:01:12,520 --> 01:01:13,220
+مجتمعية، إتصالات مجتمعية، إتصالات مجتمعية، إتصالات
+
+964
+01:01:13,220 --> 01:01:13,880
+مجتمعية، إتصالات مجتمعية، إتصالات مجتمعية، إتصالات
+
+965
+01:01:13,880 --> 01:01:17,320
+مجتمعية، إتصالات مجتمعية، إتصالات مجتمعية، إتصالات
+
+966
+01:01:17,320 --> 01:01:20,880
+مجتمعية، إتصالات
+
+967
+01:01:20,880 --> 01:01:21,800
+مجتمعية، إ
+
+968
+01:01:26,900 --> 01:01:30,560
+الخدمة الإلكترونية الولايات المتحدة على القانون
+
+969
+01:01:30,560 --> 01:01:34,800
+التجاري الأمريكي كانت مجلدًا مجلدًا مجلدًا مجلدًا
+
+970
+01:01:34,800 --> 01:01:36,080
+مجلدًا مجلدًا مجلدًا مجلدًا مجلدًا مجلدًا مجلدًا
+
+971
+01:01:36,080 --> 01:01:37,600
+مجلدًا مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد
+
+972
+01:01:37,600 --> 01:01:39,800
+مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد
+
+973
+01:01:39,800 --> 01:01:43,440
+مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد
+
+974
+01:01:43,440 --> 01:01:52,220
+مجلد مجل
+
diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/sbZMvklN-_s_postprocess.srt b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/sbZMvklN-_s_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..06719051c4b87a36843f9002097fd9172d70ad9d
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/sbZMvklN-_s_postprocess.srt
@@ -0,0 +1,3072 @@
+1
+00:00:00,000 --> 00:00:15,440
+What we
+
+2
+00:00:15,440 --> 00:00:19,000
+have today is the same chapter understanding
+
+3
+00:00:19,000 --> 00:00:22,740
+commercial law this section which is the second
+
+4
+00:00:22,740 --> 00:00:26,760
+section we have to speak about islamic commercial
+
+5
+00:00:26,760 --> 00:00:30,630
+lawو يجب أن نجيب على السؤال إذا كان لدينا حقًا
+
+6
+00:00:30,630 --> 00:00:34,670
+قانون مجتمع إسلامي أو لا؟ إذا كان لدينا قانون
+
+7
+00:00:34,670 --> 00:00:39,610
+مجتمع إسلامي أو لا؟ ماهو القانون اللي لدينا؟ ماهو
+
+8
+00:00:39,610 --> 00:00:41,690
+القانون اللي لدينا؟ ماهو القانون اللي لدينا؟ ماهو
+
+9
+00:00:41,690 --> 00:00:41,990
+القانون اللي لدينا؟ ماهو القانون اللي لدينا؟ ماهو
+
+10
+00:00:41,990 --> 00:00:43,750
+القانون اللي لدينا؟ ماهو القانون اللي لدينا؟ ماهو
+
+11
+00:00:43,750 --> 00:00:44,090
+القانون اللي لدينا؟ ماهو القانون اللي لدينا؟ ماهو
+
+12
+00:00:44,090 --> 00:00:47,100
+القانون اللي لديناWe can answer the question of
+
+13
+00:00:47,100 --> 00:00:50,320
+Islamic commercial law and if we have it, why
+
+14
+00:00:50,320 --> 00:00:52,740
+can't we apply it? What's the benefit, the
+
+15
+00:00:52,740 --> 00:00:55,500
+advantage and disadvantage of Islamic commercial
+
+16
+00:00:55,500 --> 00:01:00,100
+law? Many people would ask the question of this
+
+17
+00:01:00,100 --> 00:01:03,680
+idea if we really have it in Islamic world, we
+
+18
+00:01:03,680 --> 00:01:07,120
+have an Islamic law or not? And specifically here,
+
+19
+00:01:07,500 --> 00:01:10,700
+Islamic business law, do we have it or not? Many
+
+20
+00:01:10,700 --> 00:01:13,140
+people have different answer for that Some
+
+21
+00:01:13,140 --> 00:01:16,480
+scholars said well, no we don't haveأخرين قالوا
+
+22
+00:01:16,480 --> 00:01:20,160
+نعم لدينا، لكن إذا ننظر إلى القانون التجاري
+
+23
+00:01:20,160 --> 00:01:25,620
+الإسلامي، لا يوجد فيه نفس الطريقة، خاصة في كتاب،
+
+24
+00:01:25,620 --> 00:01:31,260
+في قطعة كتابة مختلفة، مثل جزء أخر من القانونلماذا
+
+25
+00:01:31,260 --> 00:01:34,320
+سنجعلنا نجيب على هذا النقطة بعد ذلك؟ لنرى في
+
+26
+00:01:34,320 --> 00:01:40,120
+البداية ماذا يحدث اليوم في العالم، ماذا يحدث؟ نجد
+
+27
+00:01:40,120 --> 00:01:44,340
+أنه كان هناك بعض الهجوم وهجوم وهجوم وهجوم وهجوم
+
+28
+00:01:44,340 --> 00:01:44,380
+وهجوم وهجوم وهجوم وهجوم وهجوم وهجوم وهجوم وهجوم
+
+29
+00:01:44,380 --> 00:01:50,960
+وهجوم وهجوم وهجوم وهجوم وهجوم وهجوم وهجوم
+
+30
+00:01:51,320 --> 00:01:55,500
+ماذا يعني؟ كيف يمكننا أن نفهمه؟ لأن بعد حدوث
+
+31
+00:01:55,500 --> 00:01:59,500
+سبتمبر 11، الحرب في العراق، و الوضع في بلستانيا و
+
+32
+00:01:59,500 --> 00:02:04,380
+أفغانستان، في عالم مسلم، كان هناك بعض الهدف من
+
+33
+00:02:04,380 --> 00:02:08,780
+مجتمع عالمي، من الكثير من الناس، و من الكثير من
+
+34
+00:02:08,780 --> 00:02:14,640
+المؤسسات، لكي نفهم معنى الإسلام و لكي نفهم معنى
+
+35
+00:02:14,640 --> 00:02:18,920
+الإسلام، يجب أن نفهم أيضًا هنا، في هذا الموضوع،
+
+36
+00:02:18,920 --> 00:02:24,300
+جوانب مجتمعيةالعمل والجزء المالي هل لدينا قانون
+
+37
+00:02:24,300 --> 00:02:28,140
+لذلك أو ليس لدينا قانون؟ إذا ننظر هنا مرة أخرى،
+
+38
+00:02:28,140 --> 00:02:34,180
+نجد في الوضع عام، الإسلام يغطي كل جزء من حياتنا،
+
+39
+00:02:34,180 --> 00:02:38,880
+كل جزء، الوضع السياسي، الوضع السياسي، العمل،
+
+40
+00:02:38,880 --> 00:02:45,100
+المال، المال، علاقات شخصية، كل شيء موجود، في معظم
+
+41
+00:02:45,100 --> 00:02:51,470
+الحالات لا يوجد نفسنا كما نحتاجهبشكل صحيح، يجب أن
+
+42
+00:02:51,470 --> 00:02:58,830
+نبحث عن القواعد و هذا خاصة في القوانين التجارية في
+
+43
+00:02:58,830 --> 00:03:01,890
+أي حالة إذا كنت تنظر هنا و أحتاج بعضكما للمساعدة
+
+44
+00:03:01,890 --> 00:03:04,390
+أحيانًا من وقت لوقت إذا كنا نستطيع أن نقرأ في
+
+45
+00:03:04,390 --> 00:03:07,370
+الصفحات و نستطيع أن ننظر في هذه المقالات لأن هناك
+
+46
+00:03:07,370 --> 00:03:11,250
+بعض التعاملات و بعض المقالات التي أود أن أشرحها
+
+47
+00:03:11,250 --> 00:03:14,030
+لكم في التفاصيل لكنني أريدكم أن تساعدني في القراءة
+
+48
+00:03:14,030 --> 00:03:18,040
+مثل هذه هنا الهدف في الإسلامخصوصًا، إعادة
+
+49
+00:03:18,040 --> 00:03:21,500
+الإسلامية الصحوة الإسلامية إذا تنظر إلى إعادة
+
+50
+00:03:21,500 --> 00:03:25,700
+الإسلامية في السنوات الماضية، في الكثير من المكان
+
+51
+00:03:25,700 --> 00:03:30,260
+في العالم، كما قلت مرة أخرى، كان هناك أشخاص يركزون
+
+52
+00:03:30,260 --> 00:03:38,300
+على طريقة لفهم الإسلام، كان هناك بعض الوعي، بعض
+
+53
+00:03:38,300 --> 00:03:41,760
+المعرفة، كان من المهم أن نعرف ما هي القوة
+
+54
+00:03:41,760 --> 00:03:46,380
+الإسلاميةو ماذا يحتوي على ذلك؟ نظر إلى محتوى
+
+55
+00:03:46,380 --> 00:03:49,920
+القانون الإسلامي، وجدنا أن القانون الإسلامي يغطي
+
+56
+00:03:49,920 --> 00:03:53,620
+كل مهارة لعباد الإنسان، حتى في الوضع السياسي، نظر
+
+57
+00:03:53,620 --> 00:03:59,090
+إلى الموقع السياسي، السيارة، العبادةحتى التعليم في
+
+58
+00:03:59,090 --> 00:04:02,990
+الطعام، كيف تأكل، كيف تشرب، كيف تعمل، كل شيء موجود
+
+59
+00:04:02,990 --> 00:04:08,610
+في الإسلام، لكن الناس لا يعرفون هذا قد لا تعرفين
+
+60
+00:04:08,610 --> 00:04:12,250
+أن كل ما نفعله في حياتنا سيكون فيه بعض القواعد في
+
+61
+00:04:12,250 --> 00:04:16,430
+الإسلام، هذا يمكن أن يكون واضح، و بعضهم يجب أن
+
+62
+00:04:16,430 --> 00:04:19,730
+نبحث عن هذه القواعد، سنجدها في بعض الكتب، في بعض
+
+63
+00:04:19,730 --> 00:04:25,190
+المكان. لا نستطيع أن نجد نفس الشيء في الإسلام أو
+
+64
+00:04:25,190 --> 00:04:25,670
+اليهودية
+
+65
+00:04:29,460 --> 00:04:36,920
+هل أحد يقدر أن يقرر هذا النقطة هنا مني؟ جيد، نعم
+
+66
+00:04:36,920 --> 00:04:42,500
+إنه أكتر من مفهوم المفهوم الخاص بك ومحكمته في كل
+
+67
+00:04:42,500 --> 00:04:44,860
+تفاصيل، بما في ذلك التجارب التجاربية التجاربة
+
+68
+00:04:44,860 --> 00:04:50,260
+التجاربة التجاربة التجاربة التي هي مركزناوكان
+
+69
+00:04:50,260 --> 00:04:54,880
+مضمًا في القواعد الإسلامية وفي الوقت نفسه هنا في
+
+70
+00:04:54,880 --> 00:04:58,780
+الوقت لا يمكننا أن نجد قواعد مجتمع كريستانية إذا
+
+71
+00:04:58,780 --> 00:05:03,320
+ننظر إلى التعامل والتعامل التعامل، كيف يمكنني أن
+
+72
+00:05:03,320 --> 00:05:07,660
+أسحب و أشتري و أتساوي و أحصل على تأكيد هذه
+
+73
+00:05:07,660 --> 00:05:11,300
+التفاصيل توجد في القواعد الإسلامية لكنها لا توجد
+
+74
+00:05:11,300 --> 00:05:16,420
+في القواعد الكريستانية القواعد الكريستانية لأن في
+
+75
+00:05:16,420 --> 00:05:20,870
+الإسلام لدينا اتصالينin which is theology العقيدة
+
+76
+00:05:20,870 --> 00:05:25,930
+theology how can we worship at the same time we
+
+77
+00:05:25,930 --> 00:05:29,090
+look at the behavior of a human being how can we
+
+78
+00:05:29,090 --> 00:05:32,470
+act in a society in Christianity and other
+
+79
+00:05:32,470 --> 00:05:37,360
+religions they have only one weالإنسان و الله و
+
+80
+00:05:37,360 --> 00:05:43,140
+علاقته كيف نعبد و كيف نعمل بطريقة محددة و ليس في
+
+81
+00:05:43,140 --> 00:05:47,340
+جميع المجالات و ليس في جميع المجالات في حياتنا،
+
+82
+00:05:47,340 --> 00:05:48,660
+على سبيل المثال هنا، هل لدينا القوة التجارية
+
+83
+00:05:48,660 --> 00:05:54,530
+الكريستية؟ لا لدينا قوة تجارية كريستيةنحن لدينا
+
+84
+00:05:54,530 --> 00:05:57,790
+القوة التجارية الإسلامية، يمكنك أن تسألني كيف؟ أين
+
+85
+00:05:57,790 --> 00:06:00,370
+هي؟ هل يمكننا أن نجدها؟ هل لدينا كتاب يسمى كتاب
+
+86
+00:06:00,370 --> 00:06:02,810
+التجارة الإسلامية أو لا؟ لا لدينا كتاب تجارة تجارة
+
+87
+00:06:02,810 --> 00:06:04,770
+إسلامية مثل هذا، لدينا كتاب تجارة تجارة إسلامية
+
+88
+00:06:04,770 --> 00:06:11,050
+موجودة في كتاب الله، في القرآن وموجودة في القواعد،
+
+89
+00:06:11,050 --> 00:06:15,190
+في الصنة، النبي محمد صلى الله عليه وسلم، ويجب أن
+
+90
+00:06:15,190 --> 00:06:19,170
+نبحث عن هذه النقطة، يجب أن نفهمها، يجب أن نفهمها،
+
+91
+00:06:19,170 --> 00:06:22,490
+يجب أن نطبقها لتعاملاتنا في المجتمع
+
+92
+00:06:25,470 --> 00:06:29,030
+but this time you can see nowadays I mean for the
+
+93
+00:06:29,030 --> 00:06:32,890
+past many years there has been a decline decline
+
+94
+00:06:32,890 --> 00:06:38,870
+going down in islamic law and many societies have
+
+95
+00:06:38,870 --> 00:06:42,950
+abandoned abandoned when we look at this point
+
+96
+00:06:42,950 --> 00:06:47,710
+here I mean they gave up abandoned يتخلعان they
+
+97
+00:06:47,710 --> 00:06:53,020
+left it they went for western commercial lawوحتى
+
+98
+00:06:53,020 --> 00:06:56,000
+إنهم رحلوا القواعد الإسلامية بشكل عام ..والوحيد
+
+99
+00:06:56,000 --> 00:06:59,220
+الصحيح ..والوحيد الصحيح ..والوحيد الصحيح ..والوحيد
+
+100
+00:06:59,220 --> 00:07:00,180
+الصحيح ..والوحيد الصحيح ..والوحيد الصحيح ..والوحيد
+
+101
+00:07:00,180 --> 00:07:01,460
+الصحيح ..والوحيد الصحيح ..والوحيد الصحيح ..والوحيد
+
+102
+00:07:01,460 --> 00:07:02,080
+الصحيح ..والوحيد الصحيح ..والوحيد الصحيح ..والوحيد
+
+103
+00:07:02,080 --> 00:07:02,840
+الصحيح ..والوحيد الصحيح ..والوحيد الصحيح ..والوحيد
+
+104
+00:07:02,840 --> 00:07:08,040
+الصحيح ..والوحيد الصحيح ..والوحيد الصحيح ..والوحيد
+
+105
+00:07:08,040 --> 00:07:13,440
+الصحيح ..والوحيد الصحيح ..وال
+
+106
+00:07:14,090 --> 00:07:19,170
+التشريعة مقررة ومستعمرة باستخدام القانون الإسلامي
+
+107
+00:07:19,170 --> 00:07:24,130
+ولكن بسبب إعادة الإسلامية فإستطاعت استخدام
+
+108
+00:07:24,130 --> 00:07:30,390
+التشريعة في العالم اليومي تم تفكيرها مؤخراً مؤخراً
+
+109
+00:07:30,390 --> 00:07:34,230
+يمكننا أن نرى أننا لدينا إعادة الإسلامية في الواقع
+
+110
+00:07:34,230 --> 00:07:38,990
+الكثير من البلدان وكثير من المؤسسات كانوا يعتبرون
+
+111
+00:07:39,940 --> 00:07:43,240
+عن استخدام القواعد الإسلامية بشكل عام، ليس فقط في
+
+112
+00:07:43,240 --> 00:07:46,700
+الأعمال التجارية، ولكن بشكل عام، انظر إلى ما كان
+
+113
+00:07:46,700 --> 00:07:50,140
+لدينا في القطار الآن، انظر إلى هذه اللحظة، ماذا
+
+114
+00:07:50,140 --> 00:07:55,220
+يمكنك أن ترى؟ في وقت النبي محمد بيس بي أبو الهيم،
+
+115
+00:07:55,220 --> 00:07:59,500
+في وقت الحكومة الإسلامية التي كانت موجودة لمدة
+
+116
+00:07:59,500 --> 00:08:04,140
+أكتر من 13 عامافي السنة الثلاثة عامة تلك الحكومة
+
+117
+00:08:04,140 --> 00:08:07,340
+.. تلك الحكومة .. الحكومة الإسلامية كانت تحتها
+
+118
+00:08:07,340 --> 00:08:12,580
+طريقها لأجهزة اجتماعية .. اجتماعات اجتماعية ..
+
+119
+00:08:12,580 --> 00:08:18,010
+عملية .. اقتصاد .. قوة الإنسان .. عميل مجانينأيضًا
+
+120
+00:08:18,010 --> 00:08:26,090
+الكوين والمال المستخدم في مرات مختلفة في مرات
+
+121
+00:08:26,090 --> 00:08:27,950
+مختلفة في مرات مختلفة في مرات مختلفة في مرات
+
+122
+00:08:27,950 --> 00:08:28,310
+مختلفة في مرات مختلفة في مرات مختلفة في مرات
+
+123
+00:08:28,310 --> 00:08:28,930
+مختلفة في مرات مختلفة في مرات مختلفة في مرات
+
+124
+00:08:28,930 --> 00:08:30,310
+مختلفة في مرات مختلفة في مرات مختلفة في مرات
+
+125
+00:08:30,310 --> 00:08:30,810
+مختلفة في مرات مختلفة في مرات مختلفة في مرات
+
+126
+00:08:30,810 --> 00:08:31,950
+مختلفة في مرات مختلفة في مرات مختلفة في مرات
+
+127
+00:08:31,950 --> 00:08:35,450
+مختلفة في مرات مختلفة في مرات مختلفة
+
+128
+00:08:35,450 --> 00:08:44,830
+في مرات مختلفة
+
+129
+00:08:44,830 --> 00:08:46,990
+في
+
+130
+00:08:48,140 --> 00:08:55,100
+معظمهم كانوا مارسيون محمد كان يعمل في شركة و مجتمع
+
+131
+00:08:55,100 --> 00:09:00,780
+و كان يسافر من مكان إلى مكان يسافر و يشتري أشياء و
+
+132
+00:09:00,780 --> 00:09:03,680
+كثير من أصحابه و حتى إذا تنظر مرة أخرى في ذلك
+
+133
+00:09:03,680 --> 00:09:09,280
+الوقت و حتى لاحقا في عدة مرات من الحياة وجدنا أن
+
+134
+00:09:09,280 --> 00:09:15,260
+الكثير من الناس كانوا يعملوا في شركة شركة يسافر و
+
+135
+00:09:15,260 --> 00:09:20,900
+يشتري أشياءهذا النظام أو هذا النظام تم تطويره لم
+
+136
+00:09:20,900 --> 00:09:28,220
+يتوقف في موقع واحد تستمر في التطور حتى نحن لدينا
+
+137
+00:09:28,220 --> 00:09:32,760
+نظام مميز بالكامل من الأعمال الاقتصادية والعامة
+
+138
+00:09:32,760 --> 00:09:40,350
+وكل شيء بسهولةباستخدام قواعد الإسلام، باستخدام
+
+139
+00:09:40,350 --> 00:09:43,770
+القواعد بين المسلمين اللي كانت تعتمد على القواعد
+
+140
+00:09:43,770 --> 00:09:47,410
+الإسلامية، القواعد الإسلامية اللي كانت تم اختيارها
+
+141
+00:09:47,410 --> 00:09:51,390
+بعد النبي محمد وكانت تم اختيارها من كتاب الله
+
+142
+00:09:51,390 --> 00:09:57,410
+القرآن الآن، المشكلة هي أن هذه الحالة لم تنتهي
+
+143
+00:09:57,410 --> 00:10:03,610
+أبدًا الآن، لسنا لدينا مصطلح إسلامي، لسنا لدينا
+
+144
+00:10:03,610 --> 00:10:12,210
+مصطلح إسلاميكما كانت تكون الإسلام تتخلص تماما وكان
+
+145
+00:10:12,210 --> 00:10:15,950
+فاتر في عام عشرين وعشرين وعشرين وعشرين وعشرين
+
+146
+00:10:15,950 --> 00:10:17,150
+وعشرين وعشرين وعشرين وعشرين وعشرين وعشرين وعشرين
+
+147
+00:10:17,150 --> 00:10:19,350
+وعشرين وعشرين وعشرين وعشرين وعشرين وعشرين وعشرين
+
+148
+00:10:19,350 --> 00:10:20,090
+وعشرين وعشرين وعشرين وعشرين وعشرين وعشرين وعشرين
+
+149
+00:10:20,090 --> 00:10:21,390
+وعشرين وعشرين وعشرين وعشرين وعشرين وعشرين وعشرين
+
+150
+00:10:21,390 --> 00:10:25,730
+وعشرين وعشرين وعشرين وعشرين وعشرين وعشرين وعشرين
+
+151
+00:10:25,730 --> 00:10:28,050
+وعشرين وعشرين وعشرين
+
+152
+00:10:29,430 --> 00:10:35,610
+وفي عام ٢٠٢٤ وحتى هذه اللحظة لم نكن لدينا دولة
+
+153
+00:10:35,610 --> 00:10:40,270
+إسلامية نعود إلى نفس الموضوع لنرى إن دولة
+
+154
+00:10:40,270 --> 00:10:43,050
+الإسلامية في ذلك الوقت كانت تستخدم القواعد
+
+155
+00:10:43,050 --> 00:10:48,050
+التجارية أو لا، نعم كانت تحتوي على القواعد
+
+156
+00:10:48,050 --> 00:10:53,270
+والعادلات التي نستطيع استخدامها في حياتنا، في حياة
+
+157
+00:10:53,270 --> 00:10:58,150
+العمل المشكلة هي أننا مع الوقت كان لدينا الكثير من
+
+158
+00:10:58,150 --> 00:11:03,580
+الأحداثفي الكثير من الحالات والحالات التي كانت
+
+159
+00:11:03,580 --> 00:11:10,000
+المجتمعات الغربية ومجتمعات الغربية تأخذ المجتمعات
+
+160
+00:11:10,000 --> 00:11:14,300
+المسلمة مثلًا .. انظر هنا كان هناك سلسلة طويلة من
+
+161
+00:11:14,300 --> 00:11:18,800
+الأحداث .. الكثير من الأحداث .. بعضها كانت محافظة
+
+162
+00:11:18,800 --> 00:11:23,080
+مصر .. مصر كما نعلم انها مدينة استراتيجية .. مصر
+
+163
+00:11:23,080 --> 00:11:27,180
+هي مكان قوي .. مدينة قوية .. مصر كانت محافظة ..
+
+164
+00:11:27,180 --> 00:11:28,740
+محافظة محافظة
+
+165
+00:11:31,210 --> 00:11:37,470
+أحتللها او قادت من الفرنسا في سنة و نصف و نصف و
+
+166
+00:11:37,470 --> 00:11:38,930
+نصف و نصف و نصف و نصف و نصف و نصف و نصف و نصف و
+
+167
+00:11:38,930 --> 00:11:41,290
+نصف و نصف و نصف و نصف و نصف و نصف و نصف و نصف و
+
+168
+00:11:41,290 --> 00:11:43,050
+نصف و نصف و نصف و نصف و نصف و نصف و نصف و نصف و
+
+169
+00:11:43,050 --> 00:11:43,670
+نصف و نصف و نصف و نصف و نصف و نصف و نصف و نصف و
+
+170
+00:11:43,670 --> 00:11:45,770
+نصف و نصف و نصف و نصف و نصف و نصف و نصف و نصف و
+
+171
+00:11:45,770 --> 00:11:58,270
+نصف و نصف و نصف و نصف و نصف و نصف و نصف و نصف و
+
+172
+00:11:58,270 --> 00:12:03,650
+نصوكانت أفضل القوية التجارية في العالم. كانت فرنسا
+
+173
+00:12:03,650 --> 00:12:10,570
+مدينة مدينة مدينة مدينة مدينة مدينة مدينة مدينة
+
+174
+00:12:10,570 --> 00:12:11,090
+مدينة مدينة مدينة مدينة مدينة مدينة مدينة مدينة
+
+175
+00:12:11,090 --> 00:12:11,710
+مدينة مدينة مدينة مدينة مدينة مدينة مدينة مدينة
+
+176
+00:12:11,710 --> 00:12:11,790
+مدينة مدينة مدينة مدينة مدينة مدينة مدينة مدينة
+
+177
+00:12:11,790 --> 00:12:12,350
+مدينة مدينة مدينة مدينة مدينة مدينة مدينة مدينة
+
+178
+00:12:12,350 --> 00:12:17,390
+مدينة مدينة مدينة مدينة مدينة مدينة مدينة مدينة
+
+179
+00:12:17,390 --> 00:12:20,830
+مدينة
+
+180
+00:12:20,830 --> 00:12:25,730
+مدين
+
+181
+00:12:26,280 --> 00:12:30,640
+problem was the imitation process .. imitation ..
+
+182
+00:12:30,640 --> 00:12:37,080
+تقليد imitate .. do as they do like in the Muslim
+
+183
+00:12:37,080 --> 00:12:43,220
+society people and even leaders and lawmakers
+
+184
+00:12:43,220 --> 00:12:49,280
+wanted to imitate wanted to do the same like it
+
+185
+00:12:49,280 --> 00:12:51,700
+was in the western society like it was in France
+
+186
+00:12:51,700 --> 00:12:54,600
+because they used to think well if France was a
+
+187
+00:12:54,600 --> 00:12:57,710
+leading countryإذا كان لدينا الكثير من الحكومات
+
+188
+00:12:57,710 --> 00:13:00,890
+..الحكومة الفرنسية ..الحكومة الإنقليزية ..الحكومة
+
+189
+00:13:00,890 --> 00:13:05,950
+الصينية .. و تلك الولايات المتحدة لديها القوة و
+
+190
+00:13:05,950 --> 00:13:11,270
+القوية .. و تلك الولايات المتحدة لديها أحد أفضل
+
+191
+00:13:11,270 --> 00:13:15,290
+أسلوبات القانونيةلذلك لماذا لا نفعل نفس الشيء
+
+192
+00:13:15,290 --> 00:13:19,770
+مثلهم؟ لماذا لا نأخذ نظام حقوقهم و نطبقه في
+
+193
+00:13:19,770 --> 00:13:25,710
+أمريكا؟ هذا كان شيء قمت به الكثير من المجلسين
+
+194
+00:13:25,710 --> 00:13:34,950
+والمجلسين القانونيين عمليين
+
+195
+00:13:34,950 --> 00:13:37,490
+عمليين عمليين عمليين عمليين عمليين عمليين عمليين
+
+196
+00:13:37,490 --> 00:13:42,200
+عمليين عمليين عمليين عمليين عمليين عمليينبعد ذلك
+
+197
+00:13:42,200 --> 00:13:45,220
+بسرعة
+
+198
+00:13:45,220 --> 00:13:48,960
+مفاجئة .. بسرعة مفاجئة .. بسرعة مفاجئة .. بسرعة
+
+199
+00:13:48,960 --> 00:13:50,540
+مفاجئة .. بسرعة مفاجئة .. بسرعة مفاجئة .. بسرعة
+
+200
+00:13:50,540 --> 00:13:51,200
+مفاجئة .. بسرعة مفاجئة .. بسرعة مفاجئة .. بسرعة
+
+201
+00:13:51,200 --> 00:13:52,300
+مفاجئة .. بسرعة مفاجئة .. بسرعة مفاجئة .. بسرعة
+
+202
+00:13:52,300 --> 00:13:52,360
+مفاجئة .. بسرعة مفاجئة .. بسرعة مفاجئة .. بسرعة
+
+203
+00:13:52,360 --> 00:13:54,860
+مفاجئة .. بسرعة مفاجئة .. بسرعة مفاجئة .. بسرعة
+
+204
+00:13:54,860 --> 00:14:01,420
+مفاجئة .. بسرعة مفاجئة .. بسرعة مفاجئة .. بسرعة
+
+205
+00:14:01,420 --> 00:14:02,220
+مفاجئة ..
+
+206
+00:14:07,360 --> 00:14:10,360
+Like American culture, the fast food, the fast
+
+207
+00:14:10,360 --> 00:14:14,460
+way, act, the way you can dress, you act, you
+
+208
+00:14:14,460 --> 00:14:19,260
+speak, imitation, people like to look and to do
+
+209
+00:14:19,260 --> 00:14:23,980
+like others The imitation movement led to the
+
+210
+00:14:23,980 --> 00:14:25,340
+sharia being abandoned
+
+211
+00:14:29,250 --> 00:14:34,730
+يعني تخلى عنه الشريعة كانت تتخلى بسرعة مدهشة بسرعة
+
+212
+00:14:34,730 --> 00:14:38,350
+.. بسرعة .. بسرعة .. بسرعة .. بسرعة .. بسرعة ..
+
+213
+00:14:38,350 --> 00:14:38,450
+بسرعة .. بسرعة .. بسرعة .. بسرعة .. بسرعة .. بسرعة
+
+214
+00:14:38,450 --> 00:14:39,130
+.. بسرعة .. بسرعة .. بسرعة .. بسرعة .. بسرعة ..
+
+215
+00:14:39,130 --> 00:14:41,550
+بسرعة .. بسرعة .. بسرعة .. بسرعة .. بسرعة .. بسرعة
+
+216
+00:14:41,550 --> 00:14:47,930
+.. بسرعة .. بسرعة .. بسرعة .. بسرعة .. بسرعة ..
+
+217
+00:14:47,930 --> 00:14:58,990
+بسرعة
+
+218
+00:14:59,670 --> 00:15:03,230
+family family law which we call it here in
+
+219
+00:15:03,230 --> 00:15:07,410
+Palestine قانون لحوالي الشخصية family law which is
+
+220
+00:15:07,410 --> 00:15:12,530
+looking at marriage, divorce, will, heritage these
+
+221
+00:15:12,530 --> 00:15:17,050
+points under the family law still ruled by the
+
+222
+00:15:17,050 --> 00:15:22,090
+sharia by the islamic law looking at the sharia
+
+223
+00:15:22,090 --> 00:15:25,590
+commercial law or islamic commercial law it has
+
+224
+00:15:25,590 --> 00:15:30,060
+been disappearedهو ليس موجود بعد الأن من جميع
+
+225
+00:15:30,060 --> 00:15:34,300
+المنطقة، لا أحد يستخدم القواعد التجارية كقواعد
+
+226
+00:15:34,300 --> 00:15:38,980
+تجارية إسلامية بعد الأن، وكانت هذه تتغير إلى
+
+227
+00:15:38,980 --> 00:15:48,900
+القواعد التجارية الفرنسية كما سنرى الآن الكثير
+
+228
+00:15:48,900 --> 00:15:52,440
+من الناس، الكثير من المدرسين و المقالين يسألون
+
+229
+00:15:52,440 --> 00:15:56,550
+السؤال لماذا؟لماذا المؤسسات في الإمبراطورية
+
+230
+00:15:56,550 --> 00:16:00,050
+الأوتومانية، في الحكومة الإسلامية، رحلوا حقوقهم
+
+231
+00:16:00,050 --> 00:16:04,890
+الإسلامية وذهبوا لحقوق الفرنسا التجارية؟ لماذا
+
+232
+00:16:04,890 --> 00:16:11,150
+الانتصافيين رأوا يوربيا، وليس ببناء شريعة موجودة
+
+233
+00:16:11,150 --> 00:16:16,430
+من قبل؟ لدينا نظام كامل، ممتاز، يغطي جميع جزء من
+
+234
+00:16:16,430 --> 00:16:19,650
+حياتنا، لماذا لا نأخذه منه؟ لماذا يجب أن نأخذ
+
+235
+00:16:19,650 --> 00:16:23,950
+الحقوق الإسلامية؟ ماذا تعتقد؟It's because of the
+
+236
+00:16:23,950 --> 00:16:27,250
+invasion of the western and especially European
+
+237
+00:16:27,250 --> 00:16:30,390
+invasion culturally and politically at the same
+
+238
+00:16:30,390 --> 00:16:33,830
+time, so the Rome they had to amend the Islamic
+
+239
+00:16:33,830 --> 00:16:39,650
+laws, that's it I think that's important because
+
+240
+00:16:39,650 --> 00:16:44,670
+that's actually between the states, they were ..
+
+241
+00:16:44,670 --> 00:16:50,210
+they must implement their law Yes, we have many
+
+242
+00:16:50,210 --> 00:16:54,450
+points here to look at, many reasonsهذه كانت
+
+243
+00:16:54,450 --> 00:17:00,130
+الأساسية للبرنامج بالكامل لتغيير الاهتمام من
+
+244
+00:17:00,130 --> 00:17:03,590
+القواعد التجارية الإسلامية إلى القواعد التجارية
+
+245
+00:17:03,590 --> 00:17:07,830
+الأوروبية المدرسين
+
+246
+00:17:07,830 --> 00:17:13,910
+كانوا يقولون أن نابليون بونابارت رئيس فرنسا كان
+
+247
+00:17:13,910 --> 00:17:19,510
+لديه فكرة جديدةوهو الانقلاب بين الانقلاب التجاري
+
+248
+00:17:19,510 --> 00:17:23,530
+والانقلاب غير التجاري التركيز كان على الانقلاب
+
+249
+00:17:23,530 --> 00:17:26,110
+التجاري والانقلاب التجاري والانقلاب التجاري
+
+250
+00:17:26,110 --> 00:17:29,910
+والانقلاب غير التجاري الانقلاب التجاري والانقلاب
+
+251
+00:17:29,910 --> 00:17:31,430
+غير التجاري الانقلاب التجاري والانقلاب التجاري
+
+252
+00:17:31,430 --> 00:17:31,790
+والانقلاب التجاري والانقلاب التجاري والانقلاب
+
+253
+00:17:31,790 --> 00:17:39,690
+التجاري والانقلاب التجاري والانقلاب
+
+254
+00:17:39,690 --> 00:17:43,890
+التجاري والانقلاب
+
+255
+00:17:43,890 --> 00:17:48,550
+التجwhich is a speed, special courts were set up
+
+256
+00:17:48,550 --> 00:17:51,190
+to deal with commercial disputes, because
+
+257
+00:17:51,190 --> 00:17:55,130
+everything have to be run in a speed, in a fast
+
+258
+00:17:55,130 --> 00:17:59,150
+way, we cannot wait for the civil courts, we have
+
+259
+00:17:59,150 --> 00:18:02,730
+to use our own way, which is a new way, it is
+
+260
+00:18:02,730 --> 00:18:07,510
+courts, special courts, commercial courtsو احتاجات
+
+261
+00:18:07,510 --> 00:18:11,630
+خاصة لتلك الشركات لتجعلها تعمل أعمال و تتعامل أكتر
+
+262
+00:18:11,630 --> 00:18:13,730
+و تتعامل أكتر و تتعامل أكتر و تتعامل أكتر و تتعامل
+
+263
+00:18:13,730 --> 00:18:14,870
+أكتر و تتعامل أكتر و تتعامل أكتر و تتعامل أكتر و
+
+264
+00:18:14,870 --> 00:18:17,870
+تتعامل أكتر و تتعامل أكتر و تتعامل أكتر و تتعامل
+
+265
+00:18:17,870 --> 00:18:18,150
+أكتر و تتعامل أكتر و تتعامل أكتر و تتعامل أكتر و
+
+266
+00:18:18,150 --> 00:18:19,710
+تتعامل أكتر و تتعامل أكتر و تتعامل أكتر و تتعامل
+
+267
+00:18:19,710 --> 00:18:33,070
+أكتر و
+
+268
+00:18:33,070 --> 00:18:36,930
+تتعامل أكتلتصنع المال أكتر لأن الحكومة تستطيع
+
+269
+00:18:36,930 --> 00:18:39,390
+الحصول على المساعدة أيضًا، تستطيع أن تكون قوية،
+
+270
+00:18:39,390 --> 00:18:43,290
+تستطيع أن تحمي نفس الناس. الآن نابليون بونابارد
+
+271
+00:18:43,290 --> 00:18:47,270
+كان يحاول .. أعني كجمعية كامة كان يحاول أن يساعد
+
+272
+00:18:47,270 --> 00:18:49,110
+.. أن يدعم الأعمال التجارية
+
+273
+00:18:51,960 --> 00:18:57,300
+بعمل هذا، هو يقفز مجتمعًا من مجتمعًا ويخلق نظام
+
+274
+00:18:57,300 --> 00:19:01,300
+جديد، يخلق نظام جديد وكان هذا النظام الجديد خلقه
+
+275
+00:19:01,300 --> 00:19:07,820
+فقط لأولئك الناس، لأولئك المساعدين حياة سهلة،
+
+276
+00:19:07,820 --> 00:19:12,320
+عاملات سهلة، كل شيء بسرعة، ينقض الوقت وينقض المال
+
+277
+00:19:12,320 --> 00:19:20,500
+هذه أدت في الوقت نفسه إلى التقليلof the french
+
+278
+00:19:20,500 --> 00:19:24,700
+commercial law by the ottoman empire the ottoman
+
+279
+00:19:24,700 --> 00:19:30,500
+empire the ottoman empire what it did here adopted
+
+280
+00:19:30,500 --> 00:19:36,300
+in 1850 look it's been a long time 160 years ago
+
+281
+00:19:36,300 --> 00:19:43,720
+160 years ago in 1850 the french had their own law
+
+282
+00:19:43,720 --> 00:19:46,400
+was made in 1807
+
+283
+00:19:49,750 --> 00:19:55,670
+القوة التقليدية الفرنسية كانت مجرد قوة مجرد
+
+284
+00:19:55,670 --> 00:20:03,830
+قوة مجرد
+
+285
+00:20:03,830 --> 00:20:09,530
+قوة
+
+286
+00:20:09,530 --> 00:20:14,910
+مجرد قوة مجرد قوة مجرد قوة مجرد قوة مجرد قوة مجرد
+
+287
+00:20:14,910 --> 00:20:14,970
+قوة مجرد قوة مجرد قوة مجرد قوة مجرد قوة مجرد قوة
+
+288
+00:20:14,970 --> 00:20:19,940
+مجرد قوةالتخلص من المشروع الوحيد هنا من العلماء
+
+289
+00:20:19,940 --> 00:20:20,200
+العلماء العلماء العلماء العلماء العلماء العلماء
+
+290
+00:20:20,200 --> 00:20:22,240
+العلماء العلماء العلماء العلماء العلماء العلماء
+
+291
+00:20:22,240 --> 00:20:24,340
+العلماء العلماء العلماء العلماء العلماء العلماء
+
+292
+00:20:24,340 --> 00:20:25,040
+العلماء العلماء العلماء العلماء العلماء العلماء
+
+293
+00:20:25,040 --> 00:20:25,180
+العلماء العلماء العلماء العلماء العلماء العلماء
+
+294
+00:20:25,180 --> 00:20:26,740
+العلماء العلماء العلماء العلماء العلماء العلماء
+
+295
+00:20:26,740 --> 00:20:26,940
+العلماء العلماء العلماء العلماء العلماء العلماء
+
+296
+00:20:26,940 --> 00:20:28,540
+العلماء العلماء العلماء العلماء العلماء العلماء
+
+297
+00:20:28,540 --> 00:20:33,300
+العلماء العلماء العلماء العلماء العلماء العلماء
+
+298
+00:20:33,300 --> 00:20:36,940
+العلماء
+
+299
+00:20:36,940 --> 00:20:44,460
+العلماء
+
+300
+00:20:44,460 --> 00:20:49,410
+العprocess and it's it's easy and it's better than
+
+301
+00:20:49,410 --> 00:20:53,350
+having religious process of law this led to the
+
+302
+00:20:53,350 --> 00:20:57,250
+adoption of here of the ottoman by adopting the
+
+303
+00:20:57,250 --> 00:21:01,010
+commercial law from France because complex
+
+304
+00:21:01,010 --> 00:21:06,070
+secularization people separating between religion
+
+305
+00:21:06,070 --> 00:21:11,800
+and state فصل الدين عن الدولةالعلمانية ال process
+
+306
+00:21:11,800 --> 00:21:15,820
+of secularization is to separate between the state
+
+307
+00:21:15,820 --> 00:21:21,600
+and religion you can worship you can act but at
+
+308
+00:21:21,600 --> 00:21:26,260
+the same time this have to be separated from your
+
+309
+00:21:26,260 --> 00:21:30,360
+business activities in addition to this look at
+
+310
+00:21:30,360 --> 00:21:33,080
+what we have many points here look at the
+
+311
+00:21:33,080 --> 00:21:39,440
+following factors have played a partهناك نقطة كانت
+
+312
+00:21:39,440 --> 00:21:44,180
+أساسًا لسؤال نفسه الذي كنا نجيب عليه لماذا المجتمع
+
+313
+00:21:44,180 --> 00:21:48,020
+المسلمي لماذا المملكة الأوتومانية ذهبت للقانون
+
+314
+00:21:48,020 --> 00:21:52,260
+الفرنسي ولم يتمكنوا من تطوير قانونهم الخاص بهم
+
+315
+00:21:52,260 --> 00:21:55,480
+بسبب كثير من الأسباب، واحدة منها كانت عملية
+
+316
+00:21:55,480 --> 00:21:56,340
+استرخيالية مصطلحية مصطلحية مصطلحية مصطلحية مصطلحية
+
+317
+00:21:56,340 --> 00:21:57,640
+مصطلحية مصطلحية مصطلحية مصطلحية مصطلحية مصطلحية
+
+318
+00:21:57,640 --> 00:21:59,560
+مصطلحية مصطلحية مصطلحية مصطلحية مصطلحية مصطلحية
+
+319
+00:21:59,560 --> 00:22:00,840
+مصطلحية مصطلحية
+
+320
+00:22:02,630 --> 00:22:06,250
+أوروبيا و قبل وقت طويل و قبل و قبل و قبل و قبل و
+
+321
+00:22:06,250 --> 00:22:07,610
+قبل و قبل و قبل و قبل و قبل و قبل و قبل و قبل و
+
+322
+00:22:07,610 --> 00:22:14,450
+قبل و قبل و قبل و قبل و قبل و قبل و قبل و قبل و
+
+323
+00:22:14,450 --> 00:22:16,050
+قبل و قبل و قبل و قبل و قبل و قبل و قبل و قبل و
+
+324
+00:22:16,050 --> 00:22:17,430
+قبل و قبل و قبل و قبل و قبل و قبل و قبل و قبل و
+
+325
+00:22:17,430 --> 00:22:20,670
+قبل و قبل و قبل و قبل و قبل و قبل و قبل و قبل و
+
+326
+00:22:20,670 --> 00:22:22,150
+قبل و قبل و قبل و قبل و قبل و قبل و قبل و قبل و
+
+327
+00:22:22,150 --> 00:22:22,770
+قبل و قبل و قبل و قبل و قبل و قبل و قبل و قبل و
+
+328
+00:22:22,770 --> 00:22:23,430
+قبل و قبل و قبل و قبل و قبل و قبل و قبل و قبل و
+
+329
+00:22:23,430 --> 00:22:29,690
+قبل و قبل وأوروبا كانت تسيطر على العالم كله،
+
+330
+00:22:29,690 --> 00:22:34,570
+فرنسا، إنجلان، إسبانيا، بورتغالا، تلك البلدين كانت
+
+331
+00:22:34,570 --> 00:22:39,050
+تسيطر على العالم في الواقع أن هذا حصل حتى على نظام
+
+332
+00:22:39,050 --> 00:22:43,330
+الحكومة كإنهم يستطيعون إصلاح القواعد و لا أحد
+
+333
+00:22:43,330 --> 00:22:46,950
+يستطيع أن يقول لا لأن إذا كنت تسيطر على البلد، و
+
+334
+00:22:46,950 --> 00:22:53,370
+أنت لديك تجارب جيدة و أنت لديك قيمة جيدة بعمل عمل
+
+335
+00:22:53,370 --> 00:22:54,490
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+336
+00:22:54,490 --> 00:22:55,610
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+337
+00:22:55,610 --> 00:22:56,850
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+338
+00:22:56,850 --> 00:23:00,990
+عمل عالاخرين سيميطرون .. سيميطرون .. هذا هو الرقم
+
+339
+00:23:00,990 --> 00:23:06,950
+أول .. رقم اثنان هو .. الوضع في أوروبا ان شركة
+
+340
+00:23:06,950 --> 00:23:09,270
+ميرشانت تقبل حكومة دوكتور كوردسان و تعمل حكومة
+
+341
+00:23:09,270 --> 00:23:11,550
+دوكتور كوردسان و تعمل حكومة دوكتور كوردسان و تعمل
+
+342
+00:23:11,550 --> 00:23:13,490
+حكومة دوكتور كوردسان و تعمل حكومة دوكتور كوردسان و
+
+343
+00:23:13,490 --> 00:23:14,990
+تعمل حكومة دوكتور كوردسان و تعمل حكومة دوكتور
+
+344
+00:23:14,990 --> 00:23:16,030
+كوردسان و تعمل حكومة دوكتور كوردسان و تعمل حكومة
+
+345
+00:23:16,030 --> 00:23:21,360
+دوكتور كوردسان و تعمل حكومة دوبعض من هؤلاء
+
+346
+00:23:21,360 --> 00:23:24,300
+الشرطيين الأوروبيين كانوا يأتيوا إلى الشرق الأوسط
+
+347
+00:23:24,300 --> 00:23:28,540
+و الولايات الإسلامية ليرحلوا، لتشتريوا، لتساويوا،
+
+348
+00:23:28,540 --> 00:23:31,540
+بإتيكوا إلى الشرق الأوسط، هؤلاء الشرطيين كانوا
+
+349
+00:23:31,540 --> 00:23:34,540
+يحاولوا أن يتخلصوا من القوات المنطقية ومن القوات
+
+350
+00:23:34,540 --> 00:23:39,420
+المنطقية، يتخلصوا، ليسوا يستمعوا، نفهم أن إذا كنت
+
+351
+00:23:39,420 --> 00:23:42,960
+تعيش في مكان واحد، في مكان واحد، يجب أن تتبع
+
+352
+00:23:42,960 --> 00:23:46,560
+القوة، إذا كنت تعيش في بلسطين، يجب أن تتبع القوة
+
+353
+00:23:46,560 --> 00:23:50,120
+البلسطينية، يجب أن تتبعهاإذا دخلت إلى الولايات
+
+354
+00:23:50,120 --> 00:23:53,300
+المتحدة أو الUSA، فسأحتاج أن أحتاج أن أحتاج أن
+
+355
+00:23:53,300 --> 00:23:53,360
+أحتاج أن أحتاج أن أحتاج أن أحتاج أن أحتاج أن أحتاج
+
+356
+00:23:53,360 --> 00:23:54,980
+أن أحتاج أن أحتاج أن أحتاج أن أحتاج أن أحتاج أن
+
+357
+00:23:54,980 --> 00:23:56,380
+أحتاج أن أحتاج أن أحتاج أن أحتاج أن أحتاج أن أحتاج
+
+358
+00:23:56,380 --> 00:23:58,200
+أن أحتاج أن أحتاج أن أحتج أن أحتج أن أحتج أن أحتج
+
+359
+00:23:58,200 --> 00:23:58,840
+أحتج أن أحتج أن أحتج أن أحتج أن أحتج أن أحتج أن
+
+360
+00:23:58,840 --> 00:23:59,360
+أحتج أن أحتج أن أحتج أن أحتج أن أحتج أن أحتج أن
+
+361
+00:23:59,360 --> 00:24:17,860
+أحتج أن أحتج أن أحتج أن أحتج أن أحتج أن أحتج أن
+
+362
+00:24:17,860 --> 00:24:21,790
+أحتلذلك هم لديهم طريقة أخرى، إذا كان لديك مصادق مع
+
+363
+00:24:21,790 --> 00:24:26,310
+شخص في بالستان و هو أو هي من المجتمع الأوسط في ذلك
+
+364
+00:24:26,310 --> 00:24:28,590
+الوقت، فهم كانوا يمتلكون قانونهم الخاصة، يمكنهم
+
+365
+00:24:28,590 --> 00:24:34,230
+تطبيق قانونهم الخاصة في المجتمع المجتمعي هذا ليس
+
+366
+00:24:34,230 --> 00:24:40,190
+شيء منطقي، لأنك يجب أن تتعامل مع القانون المجتمعي،
+
+367
+00:24:40,190 --> 00:24:44,430
+الأن هذا أدى إلى جهة جديدة، وهي رقم 3، وهي حقا
+
+368
+00:24:44,430 --> 00:24:45,050
+مهمة
+
+369
+00:24:56,940 --> 00:25:00,020
+This lead to a perception .. perception ..
+
+370
+00:25:00,020 --> 00:25:02,880
+thinking that local merchants in this community
+
+371
+00:25:02,880 --> 00:25:06,020
+were thinking if European merchants European
+
+372
+00:25:06,020 --> 00:25:09,020
+traders having their own law applied in our
+
+373
+00:25:09,020 --> 00:25:13,160
+country and used to avoid our courts then we have
+
+374
+00:25:13,160 --> 00:25:16,730
+to .. we have to do the same thingكانوا يفكرون و
+
+375
+00:25:16,730 --> 00:25:21,010
+يؤمنون أن القانون الأوروبي كان أفضل، كان جيدًا،
+
+376
+00:25:21,010 --> 00:25:26,030
+لذلك لا يجب أن نتعامل، لا يجب أن نقبل قانوننا، يجب
+
+377
+00:25:26,030 --> 00:25:29,950
+أن ندفع مفاتيحنا إذا كان لدينا اتفاق مع شخص من
+
+378
+00:25:29,950 --> 00:25:33,450
+المجتمعات الأوسط في بلدنا باستخدام قانونهم الخاصة
+
+379
+00:25:33,450 --> 00:25:38,630
+و ليس قانوننا الخاصة، لذلك في النهاية وجدنا أن كلا
+
+380
+00:25:38,630 --> 00:25:42,250
+الجانبين كانوا يستخدمون القانون الأوروبيمصطلحات
+
+381
+00:25:42,250 --> 00:25:47,090
+مجتمعية في الشرق الأوسط كما مصطلحات مجتمعية
+
+382
+00:25:47,090 --> 00:25:47,970
+مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية
+
+383
+00:25:47,970 --> 00:25:50,530
+مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية
+
+384
+00:25:50,530 --> 00:25:51,290
+مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية
+
+385
+00:25:51,290 --> 00:25:51,530
+مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية
+
+386
+00:25:51,530 --> 00:25:52,830
+مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية
+
+387
+00:25:52,830 --> 00:25:59,090
+مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية مجتمعية
+
+388
+00:25:59,090 --> 00:26:09,030
+مجتمعية مجتمعية مجتم
+
+389
+00:26:10,340 --> 00:26:13,800
+فرنسا كانت مدينة رئيسية ولكنها لم تكن المكان
+
+390
+00:26:13,800 --> 00:26:17,300
+الوحيد .. لم يكن المدينة الوحيدة التي كانت تستخدم
+
+391
+00:26:17,300 --> 00:26:21,040
+حقوقها لو تنظر هنا .. تجد أن حتى الشركات الأوروبية
+
+392
+00:26:21,040 --> 00:26:26,080
+.. معظم الشركات الأوروبية تحب الفكرة الفرنسية ..
+
+393
+00:26:26,080 --> 00:26:29,180
+الفكرة الفرنسية وكانوا يعتقدوا أن الفكرة الفرنسية
+
+394
+00:26:29,180 --> 00:26:32,860
+كانت أفضل .. وكانت .. الفكرة الفرنسية كانت أفضل
+
+395
+00:26:32,860 --> 00:26:35,680
+فكرة .. فكرة، حكومة، حكومة، حكومة، حكومة، حكومة،
+
+396
+00:26:35,680 --> 00:26:36,120
+حكومة، حكومة، حكومة، حكومة، حكومة، حكومة، حكومة،
+
+397
+00:26:36,120 --> 00:26:43,250
+حكومة، حكومة، حكI'll accept and implement French
+
+398
+00:26:43,250 --> 00:26:47,870
+law their own disputes .. their own disputes In
+
+399
+00:26:47,870 --> 00:26:49,770
+addition to this there is another point here
+
+400
+00:26:49,770 --> 00:26:56,240
+before familiarity .. familiarity .. similarityمع
+
+401
+00:26:56,240 --> 00:27:01,600
+فكرة ومعرفة قانونية من القانونية في مجالات معينة
+
+402
+00:27:01,600 --> 00:27:07,280
+كانت بسهولة، الناس عارفة في أوروبا، الناس عارفة
+
+403
+00:27:07,280 --> 00:27:12,580
+بقانونية، قانونية بشخص، ليس قانونية دينية، هذا
+
+404
+00:27:12,580 --> 00:27:17,480
+جعلتها واضحة وسهلة لكثير من المرسلين لتقبل
+
+405
+00:27:17,480 --> 00:27:25,020
+القوانين المختلفة، وجدنا بفعل هذاالعلاقات العلمية
+
+406
+00:27:25,020 --> 00:27:27,240
+العلمية العلمية العلمية العلمية العلمية العلمية
+
+407
+00:27:27,240 --> 00:27:27,440
+العلمية العلمية العلمية العلمية العلمية العلمية
+
+408
+00:27:27,440 --> 00:27:30,540
+العلمية العلمية العلمية العلمية العلمية العلمية
+
+409
+00:27:30,540 --> 00:27:30,640
+العلمية العلمية العلمية العلمية العلمية العلمية
+
+410
+00:27:30,640 --> 00:27:33,260
+العلمية العلمية العلمية العلمية العلمية العلمية
+
+411
+00:27:33,260 --> 00:27:34,740
+العلمية العلمية العلمية العلمية العلمية العلمية
+
+412
+00:27:34,740 --> 00:27:34,760
+العلمية العلمية العلمية العلمية العلمية العلمية
+
+413
+00:27:34,760 --> 00:27:35,060
+العلمية العلمية العلمية العلمية العلمية العلمية
+
+414
+00:27:35,060 --> 00:27:39,720
+العلمية العلمية العلمية العلمية العلمية العلمية
+
+415
+00:27:39,720 --> 00:27:39,800
+العلمية العلمية العلمية العلمية العلمية العلمية
+
+416
+00:27:39,800 --> 00:27:41,500
+العلمية العلمية العلمية العلمية العلمية العلمية
+
+417
+00:27:53,690 --> 00:27:57,550
+to make them happy and people so accepted those
+
+418
+00:27:57,550 --> 00:28:00,950
+quotes like what's happening nowadays in many
+
+419
+00:28:00,950 --> 00:28:05,450
+societies people most likely want to please their
+
+420
+00:28:05,450 --> 00:28:08,910
+leaders please يعني يرضي want to make them happy
+
+421
+00:28:08,910 --> 00:28:15,050
+so that's what here this led to the adoption of
+
+422
+00:28:15,050 --> 00:28:19,190
+french commercial law at the ottoman empire number
+
+423
+00:28:19,190 --> 00:28:25,430
+seven is you want to read itبالنسبة للملاحظة أن
+
+424
+00:28:25,430 --> 00:28:29,570
+المواصفات التجارية لم تكن مهمة دينية بشكل كبير،
+
+425
+00:28:29,570 --> 00:28:33,050
+فالملاحظات التي قد تكون قد تكون قد تكون قد تكون قد
+
+426
+00:28:33,050 --> 00:28:33,550
+تكون قد تكون قد تكون قد تكون قد تكون قد تكون قد
+
+427
+00:28:33,550 --> 00:28:34,290
+تكون قد تكون قد تكون قد تكون قد تكون قد تكون قد
+
+428
+00:28:34,290 --> 00:28:34,850
+تكون قد تكون قد تكون قد تكون قد تكون قد تكون قد
+
+429
+00:28:34,850 --> 00:28:34,870
+تكون قد تكون قد تكون قد تكون قد تكون قد تكون قد
+
+430
+00:28:34,870 --> 00:28:35,350
+تكون قد تكون قد تكون قد تكون قد تكون قد تكون قد
+
+431
+00:28:35,350 --> 00:28:50,650
+تكون قد تكون قد تكون قد تكون قد
+
+432
+00:28:50,650 --> 00:28:56,900
+تكونالناس يفكرون أن المواصفات الإيمانية تتعامل
+
+433
+00:28:56,900 --> 00:29:02,880
+أكتر مع عائلة، مع الناس، العلاقة، انها ليست مرتبطة
+
+434
+00:29:02,880 --> 00:29:07,340
+بالتجارة، لذا في التجارة والعمل، نحن نستطيع أن
+
+435
+00:29:07,340 --> 00:29:12,160
+نقوم و نستطيع أن نتعامل بأي قوة، أي عمل، من أي
+
+436
+00:29:12,160 --> 00:29:16,300
+مكان، فرنسا، من الولايات المتحدة، من ألمانيا، من
+
+437
+00:29:16,300 --> 00:29:20,810
+أي مكان آخر، اللي كان من المفترض أن يكون بخيرهذا
+
+438
+00:29:20,810 --> 00:29:24,250
+جعل الناس تقول حسنا نستطيع استخدام القواعد
+
+439
+00:29:24,250 --> 00:29:29,070
+الفرنسية في العالم الإسلامي و هذا ما حدث في عام
+
+440
+00:29:29,070 --> 00:29:36,270
+1807 القواعد الفرنسي التجاربي كان صنعه كان صنعه في
+
+441
+00:29:36,270 --> 00:29:40,930
+عام 1807 تم إشتره من أوتومان هنا تم إشتره كقواعد
+
+442
+00:29:40,930 --> 00:29:46,490
+التجارب الأوتومانية في عام 1850 تخيل في عام 1850
+
+443
+00:29:46,490 --> 00:29:53,200
+هذا القواعد تم إشترهمن أهيا ومن فرنسا وكانت قبولة
+
+444
+00:29:53,200 --> 00:29:57,480
+من إمبراطورية أوتومان ونحن في باليستان نحن تحت
+
+445
+00:29:57,480 --> 00:30:00,860
+إمبراطورية أوتومان، باليستان كانت جزء من
+
+446
+00:30:00,860 --> 00:30:06,940
+إمبراطورية أوتومان، منذ ذلك الوقت حتى الآن من 1850
+
+447
+00:30:06,940 --> 00:30:13,320
+حتى الآن نستعمل ما يسمى كميرشيا، إنه غير مؤمنIt's
+
+448
+00:30:13,320 --> 00:30:16,800
+out of date .. expired .. it's not suitable for
+
+449
+00:30:16,800 --> 00:30:19,680
+our life .. we cannot use it .. we should not ..
+
+450
+00:30:19,680 --> 00:30:22,720
+you see business and commerce developing day after
+
+451
+00:30:22,720 --> 00:30:25,820
+day .. we have something new .. but we still use
+
+452
+00:30:25,820 --> 00:30:30,940
+it .. something was made in 1850 .. look at
+
+453
+00:30:30,940 --> 00:30:34,660
+western societies like in France .. in UK ..
+
+454
+00:30:34,660 --> 00:30:38,040
+America .. they use something new .. like every
+
+455
+00:30:38,040 --> 00:30:43,110
+few months they evaluateوالكودات التجارية كلها
+
+456
+00:30:43,110 --> 00:30:48,870
+لنرى إذا كانت مناسبة للناس لإستخدامها أو لا ولكننا
+
+457
+00:30:48,870 --> 00:30:55,530
+ما زلنا نستخدم شيء قديم جدًا، شيء قديم جدًا مثلًا،
+
+458
+00:30:55,530 --> 00:31:00,810
+مع الوقت هنا، لدينا اكتشافات أكتر في قانون الحكومة
+
+459
+00:31:00,810 --> 00:31:07,690
+تتبع طريقة الانتقال بين الأعمال والمعمال حتى وعن
+
+460
+00:31:07,690 --> 00:31:13,020
+نفس الفكرة التي كانت مجهودة من نابليونالناس كانت
+
+461
+00:31:13,020 --> 00:31:19,440
+تتبع نفس المثال نفس الميكانيزم للتعامل مع جمهور
+
+462
+00:31:19,440 --> 00:31:22,960
+مجتمع الإسلام والمجتمع الإسلامي والمجتمع الإسلامي
+
+463
+00:31:22,960 --> 00:31:23,260
+والمجتمع الإسلامي والمجتمع الإسلامي والمجتمع
+
+464
+00:31:23,260 --> 00:31:23,540
+الإسلامي والمجتمع الإسلامي والمجتمع الإسلامي
+
+465
+00:31:23,540 --> 00:31:26,300
+والمجتمع الإسلامي والمجتمع الإسلامي والمجتمع
+
+466
+00:31:26,300 --> 00:31:29,560
+الإسلامي
+
+467
+00:31:29,560 --> 00:31:30,700
+والمجتمع الإسلامي والمجتمع الإسلامي والمجتمع
+
+468
+00:31:30,700 --> 00:31:33,640
+الإسلامي والمجتمع الإسلامي والمجتمع الإسلامي
+
+469
+00:31:33,640 --> 00:31:37,340
+والمجتمع
+
+470
+00:31:39,450 --> 00:31:42,110
+ماذا تعتقد؟ هل نستطيع أن نطبق القوة التجارية بعد
+
+471
+00:31:42,110 --> 00:31:47,010
+كل ما لدينا؟ في الإسلام؟ في القوة التجارية
+
+472
+00:31:47,010 --> 00:31:51,270
+الإسلامية، هل نستطيع أن نتعامل بها؟
+
+473
+00:31:51,270 --> 00:31:55,410
+أعتقد أننا يجب أن نفعل بعد جميع القوات التجارية
+
+474
+00:31:55,410 --> 00:32:01,230
+الأخرى التي فشلت أن نخرج من المشاكل التي كانت
+
+475
+00:32:01,230 --> 00:32:03,790
+هناك، مثل الانتقال والانتقال
+
+476
+00:32:14,550 --> 00:32:18,350
+despite the fact that some only few schoolers some
+
+477
+00:32:18,350 --> 00:32:21,450
+people few schoolers few people are interested in
+
+478
+00:32:21,450 --> 00:32:25,810
+islamic commercial law but with the revival of
+
+479
+00:32:25,810 --> 00:32:28,870
+islam we call it islamic revival الصحة الإسلامية
+
+480
+00:32:28,870 --> 00:32:34,410
+for the past few yearsالناس كانت تركز على هذا
+
+481
+00:32:34,410 --> 00:32:39,110
+النقطة و الكثير من المدرسين اليوم يفكرون أنه أفضل
+
+482
+00:32:39,110 --> 00:32:42,890
+أن نستطيع .. نستطيع اليوم أن نتعامل بقوات إسلامية
+
+483
+00:32:42,890 --> 00:32:49,650
+مالية إسلامية قانون عمل إسلامي خاصة في 2008 2008
+
+484
+00:32:49,650 --> 00:32:55,750
+تعرفين ما حدث في الأمم المتعاملين حتى اليوم إذا
+
+485
+00:32:55,750 --> 00:32:58,130
+كنت تنظر إلى أمريكا و الكثير من البلدان الأوروبية
+
+486
+00:32:58,130 --> 00:33:03,920
+تنظر إلى غريس اليونانقريس بورتغالا قريبا من
+
+487
+00:33:03,920 --> 00:33:10,800
+الانفجار الولايات المتحدة في حالة تجارب حالة تجارب
+
+488
+00:33:10,800 --> 00:33:12,020
+حالة تجارب حالة تجارب حالة تجارب حالة تجارب حالة
+
+489
+00:33:12,020 --> 00:33:13,800
+تجارب حالة تجارب حالة تجارب حالة تجارب حالة تجارب
+
+490
+00:33:13,800 --> 00:33:14,120
+حالة تجارب حالة تجارب حالة تجارب حالة تجارب حالة
+
+491
+00:33:14,120 --> 00:33:14,200
+تجارب حالة تجارب حالة تجارب حالة تجارب حالة تجارب
+
+492
+00:33:14,200 --> 00:33:16,180
+تجارب حالة تجارب حالة تجارب حالة تجارب
+
+493
+00:33:29,190 --> 00:33:31,770
+و حتى لو تنظر في الولايات المتحدة على سبيل المثال
+
+494
+00:33:31,770 --> 00:33:35,510
+و أشخاص من البلدان الأوروبية الاخرى هم يتخلصوا من
+
+495
+00:33:35,510 --> 00:33:38,910
+القوة الإسلامية .. أعني القوة التجارية الإسلامية
+
+496
+00:33:38,910 --> 00:33:44,390
+في بعض الأجانب من نظام مصرفهم و نظامهم الاقتصادي،
+
+497
+00:33:44,390 --> 00:33:49,290
+أعني ليس تماماً لكن على الأقل هم يفهموا حاجة تتخلص
+
+498
+00:33:49,290 --> 00:33:55,810
+من نظامهم و خاصة بعد .. من السنة الماضية .. من
+
+499
+00:33:55,810 --> 00:33:59,840
+السنة الماضية .. سنة، عشر سنة، حبافي السنة
+
+500
+00:33:59,840 --> 00:34:07,620
+الماضية، وكنت أبحث عن قيمة الهواء، الهواء، ومهمة
+
+501
+00:34:07,620 --> 00:34:13,480
+البلدان الغربية، ومهمة هذه المنطقة في العالم في
+
+502
+00:34:13,480 --> 00:34:18,480
+الواقع في الواقع في الواقع في الواقع في الواقع في
+
+503
+00:34:18,480 --> 00:34:19,160
+الواقع
+
+504
+00:34:33,500 --> 00:34:38,660
+أبقى أبقى أبقى
+
+505
+00:34:38,660 --> 00:34:49,560
+أبقى أبقى
+
+506
+00:34:49,560 --> 00:34:50,100
+أبقى أبقى أبقى أبقى أبقى أبقى أبقىهربت in
+
+507
+00:34:50,100 --> 00:34:52,640
+commercial law .. islamic commercial law ..
+
+508
+00:34:52,640 --> 00:34:56,540
+islamic financial law .. because they think there
+
+509
+00:34:56,540 --> 00:34:59,920
+is a way they can build their own financial and
+
+510
+00:34:59,920 --> 00:35:07,000
+economic aspects by using a perfect system .. a
+
+511
+00:35:07,000 --> 00:35:09,540
+perfect model .. which is an islamic model ..
+
+512
+00:35:09,540 --> 00:35:11,300
+despite the fact that we are going to see later on
+
+513
+00:35:11,300 --> 00:35:15,280
+that we do not have a specific commercial law set
+
+514
+00:35:15,280 --> 00:35:20,170
+in a piece of paperيجب أن نبحث عن هذه القوات وعن
+
+515
+00:35:20,170 --> 00:35:22,990
+هذه الأعمال يجب أن نبحث عنها كما سنرى في المقالات
+
+516
+00:35:22,990 --> 00:35:27,370
+الأولى أو الثانية كيف يمكننا أن نفعل ذلك؟ بالإضافة
+
+517
+00:35:27,370 --> 00:35:35,130
+إلى معنى العالم الذي نعيشه اليوم عن إسلامية الكثير
+
+518
+00:35:35,130 --> 00:35:39,050
+من المجتمعات الكثير من المجتمعات الكثير من البلدان
+
+519
+00:35:39,050 --> 00:35:43,670
+المتحركة اليوم تجاه الإسلام مثلًا، انظر إلى إيران،
+
+520
+00:35:43,670 --> 00:35:49,140
+سعوديا، تركيا، وفلسطينوحتى في مدينة إيجابية، في
+
+521
+00:35:49,140 --> 00:35:52,420
+الكثير من البلدان، إنهم يتحركوا إلى إسلامية
+
+522
+00:35:52,420 --> 00:35:59,580
+المجتمعات، إسلامية المجتمعات، هذا سيؤدي بالتأكيد،
+
+523
+00:35:59,580 --> 00:36:05,900
+هذا سيؤدي إلى استخدام الإسلام كأسلوك الرئيسي،
+
+524
+00:36:05,900 --> 00:36:10,380
+كأسلوك الرئيسي، كأسلوك الرئيسي، أعني إنه أسلوك
+
+525
+00:36:10,380 --> 00:36:12,140
+الرئيسي، أسلوك الرئيسي، لكن على الأقل يمكنهم
+
+526
+00:36:12,140 --> 00:36:16,690
+استخدام القوة الإسلامية، وإستخدام الإسلامfor all
+
+527
+00:36:16,690 --> 00:36:20,130
+aspects in their life. The whole process of
+
+528
+00:36:20,130 --> 00:36:23,230
+Islamization this would lead to adopt commercial
+
+529
+00:36:23,230 --> 00:36:26,230
+law in Islam. Islamic commercial law to be the
+
+530
+00:36:26,230 --> 00:36:29,870
+main basis for people who work in trade, in
+
+531
+00:36:29,870 --> 00:36:30,190
+business
+
+532
+00:36:40,730 --> 00:36:45,890
+بالرغم من هذا، هل نستطيع أن نقول اليوم .. اليوم
+
+533
+00:36:45,890 --> 00:36:51,690
+أننا لسنا لدينا قوة مجتمعية في الإسلام؟ هل لدينا
+
+534
+00:36:51,690 --> 00:36:55,170
+قوة مجتمعية في الإسلام او لا؟ قلنا في البداية أننا
+
+535
+00:36:55,170 --> 00:37:00,210
+لدينا بعض النقطة و بعض القواعد و بعض القواعد و تلك
+
+536
+00:37:00,210 --> 00:37:06,790
+القواعد من جهة مجتمعية توجد في الإسلام كيف نجدهم؟
+
+537
+00:37:06,790 --> 00:37:08,270
+كيف نبحث عنهم؟
+
+538
+00:37:11,720 --> 00:37:18,280
+مناقشة القرآن والسنة، لكن هل لدينا أي بلد في
+
+539
+00:37:18,280 --> 00:37:24,420
+العالم التي تستخدمها؟
+
+540
+00:37:24,420 --> 00:37:28,920
+إذا رأيت
+
+541
+00:37:28,920 --> 00:37:31,660
+هنا، انتظر، United Arab Emirates
+
+542
+00:37:34,680 --> 00:37:37,440
+يستخدمون القانون السياسي، ليس لديهم القانون
+
+543
+00:37:37,440 --> 00:37:41,940
+التجاري، ليس هناك قانون تجاري، لماذا؟ لأن القانون
+
+544
+00:37:41,940 --> 00:37:46,780
+السياسي يحتوي على القانون التجاري، قالوا أننا لا
+
+545
+00:37:46,780 --> 00:37:51,200
+نحتاج لدينا تدبليكيشن، ليس هناك حاجة لقانون تجاري
+
+546
+00:37:51,200 --> 00:37:55,070
+أو سياسيالطريقة الأفضل هي أن تكون لديها فقط قانون
+
+547
+00:37:55,070 --> 00:37:59,310
+عالمي لأن القانون العالمي يحتوي على عاملات مجتمعية
+
+548
+00:37:59,310 --> 00:38:03,730
+وإذا كانت تحتوي على عاملات مجتمعية، فهذا يكفي،
+
+549
+00:38:03,730 --> 00:38:06,570
+يمكن أن يكون مستخدم، يمكن أن يكون استخدام من جميع
+
+550
+00:38:06,570 --> 00:38:11,250
+الناس، شركات وشركات غير شركات في مجتمع. إذا تنظر
+
+551
+00:38:11,250 --> 00:38:15,350
+هنا، ماذا يحدث في إمارات العربي المتحدة؟
+
+552
+00:38:19,470 --> 00:38:23,550
+it's not possible to achieve a total isolation of
+
+553
+00:38:23,550 --> 00:38:26,590
+commercial law for example in the united arab
+
+554
+00:38:26,590 --> 00:38:29,850
+emirates the fundamental law is the civil code
+
+555
+00:38:29,850 --> 00:38:33,990
+based on the sharia the commercial code is a set
+
+556
+00:38:33,990 --> 00:38:40,570
+of variations from and additions to the civil code
+
+557
+00:38:40,570 --> 00:38:44,030
+so the commercial code is subject to sharia good
+
+558
+00:38:44,030 --> 00:38:47,430
+united arab emirates they don't havecommercial law
+
+559
+00:38:47,430 --> 00:38:51,190
+they have civil law which is fundamental law it is
+
+560
+00:38:51,190 --> 00:38:54,170
+fundamental people use it in all aspects in all
+
+561
+00:38:54,170 --> 00:38:56,890
+the relationship between individuals companies
+
+562
+00:38:56,890 --> 00:39:00,870
+institutions it is islamic law it's based on islam
+
+563
+00:39:00,870 --> 00:39:04,710
+it came from islam even not only in united arab
+
+564
+00:39:04,710 --> 00:39:07,810
+emirates some scholars were saying that french
+
+565
+00:39:07,810 --> 00:39:11,110
+civil law was based on hanafi school
+
+566
+00:39:14,080 --> 00:39:17,800
+أكتر منها كانت مصممة على تلك المدرسة سوف ننظر إلى
+
+567
+00:39:17,800 --> 00:39:21,920
+بعض المجالات من هذا في زيارة الوقت زيارة الوقت؟
+
+568
+00:39:21,920 --> 00:39:26,820
+نعم قواعد عالمية مصممة على الشريعة و تلك القواعد
+
+569
+00:39:26,820 --> 00:39:31,440
+العالمية تحتوي على .. تحتوي على مجالات شركية، نعم
+
+570
+00:39:31,440 --> 00:39:37,880
+القواعد الشركية هي عملية SIP من إضافة إلىسيول قوات
+
+571
+00:39:37,880 --> 00:39:43,500
+، كيف يمكنني ان احل اقارب بين اثنين اشخاص اذا لم
+
+572
+00:39:43,500 --> 00:39:46,940
+اكن لدي قانون اشخاص اشخاص اشخاص اشخاص اشخاص اشخاص
+
+573
+00:39:46,940 --> 00:39:47,100
+اشخاص اشخاص اشخاص اشخاص اشخاص اشخاص اشخاص اشخاص
+
+574
+00:39:47,100 --> 00:39:48,280
+اشخاص اشخاص اشخاص اشخاص اشخاص اشخاص اشخاص اشخاص
+
+575
+00:39:48,280 --> 00:40:05,060
+اشخاص اشخاص اشخاص اشخاص اشخاص اشخاص اشخاص اشخاص ا
+
+576
+00:40:05,390 --> 00:40:08,610
+لا يوجد قانون مجتمع مجتمع لا يوجد قانون مجتمع لا
+
+577
+00:40:08,610 --> 00:40:12,570
+يوجد قانون مجتمع لا يوجد قانون مجتمع لا يوجد قانون
+
+578
+00:40:12,570 --> 00:40:13,130
+مجتمع لا يوجد قانون مجتمع لا يوجد قانون مجتمع لا
+
+579
+00:40:13,130 --> 00:40:14,930
+مجتمع لا يوجد قانون مجتمع لا يوجد قانون مجتمع لا
+
+580
+00:40:14,930 --> 00:40:16,890
+يوجد قانون مجتمع لا يوجد قانون مجتمع لا يوجد قانون
+
+581
+00:40:16,890 --> 00:40:19,850
+مجتمع لا يوجد قانون مجتمع لا يوجد قانون مجتمع لا
+
+582
+00:40:19,850 --> 00:40:26,210
+يوجد قانون مجتمع لا يوجد قانون
+
+583
+00:40:26,210 --> 00:40:30,410
+مجتمع لا
+
+584
+00:40:30,410 --> 00:40:36,790
+يوجد قانون مجتمعبسبب أنه يمكن أن يساعدنا في الحصول
+
+585
+00:40:36,790 --> 00:40:42,290
+على حقوق بسيطة بسيطة
+
+586
+00:40:42,290 --> 00:40:45,450
+بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة
+
+587
+00:40:45,450 --> 00:40:47,290
+بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة
+
+588
+00:40:47,290 --> 00:40:50,850
+بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة
+
+589
+00:40:50,850 --> 00:40:51,790
+بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة
+
+590
+00:40:51,790 --> 00:41:00,510
+بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسي
+
+591
+00:41:03,830 --> 00:41:08,950
+general law of contract نحن سندرس contract في هذا
+
+592
+00:41:08,950 --> 00:41:11,630
+العام إذا كنا ننظر إلى contract ننظر إلى كيف
+
+593
+00:41:11,630 --> 00:41:14,330
+يمكننا أن نبنيه وكيف الكثير من الواضحات نحن لدينا
+
+594
+00:41:14,330 --> 00:41:18,870
+offer و acceptance نحن لدينا consideration و نحن
+
+595
+00:41:18,870 --> 00:41:22,950
+لدينا intention هؤلاء هم الواضحات اللي هي الواضحة
+
+596
+00:41:22,950 --> 00:41:28,410
+السياسية و ليست الواضحة الشركةit's the same thing
+
+597
+00:41:28,410 --> 00:41:33,170
+it's the same agency we have principal agent and
+
+598
+00:41:33,170 --> 00:41:37,650
+third party customer in civil and commercial law
+
+599
+00:41:37,650 --> 00:41:42,210
+they are the same general law of contract law of
+
+600
+00:41:42,210 --> 00:41:47,530
+property ملكيةو القانون هنا و القانون اللي يتعلق
+
+601
+00:41:47,530 --> 00:41:50,990
+بالتغيير من الحقوق المشاركات بين القانون السياسي و
+
+602
+00:41:50,990 --> 00:41:55,530
+القانون التجاري حتى لو كما في بلستان و اخر مكان
+
+603
+00:41:55,530 --> 00:41:59,970
+اذا فقدنا نقطة في القانون التجاري كما قلت قبل ان
+
+604
+00:41:59,970 --> 00:42:02,670
+القانون التجاري الفلسطيني خارج الوقت لا يمكننا أن
+
+605
+00:42:02,670 --> 00:42:06,010
+نستخدمه انه مرتبط بالوقت في هذه الحالة ما يمكننا
+
+606
+00:42:06,010 --> 00:42:10,750
+أن نفعله إذا لم نجد حلول ما يمكننا أن نفعله اليوم
+
+607
+00:42:10,750 --> 00:42:15,050
+لدينا القانون التجاريولكن هذه القانونية التجارية
+
+608
+00:42:15,050 --> 00:42:21,310
+ليست مرسومة لأنها قديمة جدا فأنا أستطيع أن أذهب
+
+609
+00:42:21,310 --> 00:42:25,990
+للقانون السياسي لأن القانون السياسي هو المصدر
+
+610
+00:42:25,990 --> 00:42:30,250
+الرئيسي للقانون التجارية نستطيع أن نذهب و نبحث عن
+
+611
+00:42:30,250 --> 00:42:34,710
+ما نحتاجه بالضبط و بذلك نستطيع أن نرى أن الجوانب
+
+612
+00:42:34,710 --> 00:42:41,010
+التجارية للشريعة لا يمكن أن يكون مغلقا
+
+613
+00:42:47,530 --> 00:42:56,170
+تسلسلين .. لدينا تسلسلين لننهي بهم في مقابل ما
+
+614
+00:42:56,170 --> 00:42:57,770
+قلناه قبل قليل من الوقت قبل قليل من الوقت قبل قليل
+
+615
+00:42:57,770 --> 00:42:58,050
+من الوقت قبل قليل من الوقت قبل قليل من الوقت قبل
+
+616
+00:42:58,050 --> 00:42:59,650
+قليل من الوقت قبل قليل من الوقت قبل قليل من الوقت
+
+617
+00:42:59,650 --> 00:42:59,750
+قبل قليل من الوقت قبل قليل من الوقت قبل قليل من
+
+618
+00:42:59,750 --> 00:43:00,390
+الوقت قبل قليل من الوقت قبل قليل من الوقت قبل قليل
+
+619
+00:43:00,390 --> 00:43:01,090
+من الوقت قبل قليل من الوقت قبل قليل من الوقت قبل
+
+620
+00:43:01,090 --> 00:43:01,970
+قليل من الوقت قبل قليل من الوقت قبل قليل من الوقت
+
+621
+00:43:01,970 --> 00:43:14,510
+قبل قليل من الوقت قبل
+
+622
+00:43:14,510 --> 00:43:20,960
+قليل من الوقت قبلوهو مجلة الحكام العدلية باريسطون
+
+623
+00:43:20,960 --> 00:43:23,600
+مجلة الحكام العدلية which is the ottoman
+
+624
+00:43:23,600 --> 00:43:30,760
+qualification of the Hanafi school there is
+
+625
+00:43:30,760 --> 00:43:37,900
+academic journal and this academic journal is
+
+626
+00:43:37,900 --> 00:43:41,920
+legal journal in which all legal codes are
+
+627
+00:43:41,920 --> 00:43:46,210
+publishedthis exists in Palestine and this used to
+
+628
+00:43:46,210 --> 00:43:49,010
+be at the time of the Ottoman Empire which used to
+
+629
+00:43:49,010 --> 00:43:51,350
+be called مجلة الأحكام العدلية
+
+630
+00:43:54,640 --> 00:43:55,220
+الصحيفة الرسمية بلستان الجريدة الرسمية nowadays
+
+631
+00:43:55,220 --> 00:43:56,720
+they call it بالصحيفة الرسمية بلستان الجريدة
+
+632
+00:43:56,720 --> 00:44:02,340
+الرسمية الصحيفة الرسمية الصحيفة
+
+633
+00:44:02,340 --> 00:44:09,000
+الرسمية الصحيفة الرسمية الصحيفة الرسمية الصحيفة
+
+634
+00:44:09,000 --> 00:44:11,600
+الرسمية الصحيفة الرسمية الصحيفة الرسمية الصحيفة
+
+635
+00:44:11,600 --> 00:44:12,180
+الرسمية الصحيفة الرسمية الصحيفة الرسمية الصحيفة
+
+636
+00:44:12,180 --> 00:44:12,840
+الرسمية الصحيفة الرسمية الصحيفة الرسمية الصحيفة
+
+637
+00:44:12,840 --> 00:44:20,560
+الرسمية الصحيفة الرسمية الصحيفة
+
+638
+00:44:20,560 --> 00:44:26,890
+الرسمية الصحيفة الرthe only western law could deal
+
+639
+00:44:26,890 --> 00:44:31,570
+with the complexities of modern commerce modern
+
+640
+00:44:31,570 --> 00:44:36,610
+commerce it's the only saying again that Muslims
+
+641
+00:44:36,610 --> 00:44:40,130
+could not have their own law they could not
+
+642
+00:44:40,130 --> 00:44:45,550
+explain their needs they could not codify what
+
+643
+00:44:45,550 --> 00:44:48,810
+they want in a branch of law to respond to their
+
+644
+00:44:48,810 --> 00:44:52,670
+needs now they went they look for the easiest way
+
+645
+00:44:53,690 --> 00:44:58,870
+وكانوا يبحثون عن طريقة أسهل ليس لإجراء أعمال أقل
+
+646
+00:44:58,870 --> 00:45:02,150
+منهم وكانوا يجدوا أن الطريقة الأسهل كانت فقط
+
+647
+00:45:02,150 --> 00:45:06,110
+لإستعمال نفس القواعد فهم ذهبوا إلى فرنسا وكانوا
+
+648
+00:45:06,110 --> 00:45:09,330
+يحصلوا على القواعد الفرنسية وعادوا وقالوا هذا هو
+
+649
+00:45:09,330 --> 00:45:13,340
+القواعد اخذوهUse it. We know from the beginning
+
+650
+00:45:13,340 --> 00:45:17,980
+that each society has its own needs In our society
+
+651
+00:45:17,980 --> 00:45:20,560
+we might have some needs which can be completely
+
+652
+00:45:20,560 --> 00:45:23,740
+different from European societies And even within
+
+653
+00:45:23,740 --> 00:45:28,160
+Europe, the French society has different needs
+
+654
+00:45:28,160 --> 00:45:32,160
+from the English or the German societies So at
+
+655
+00:45:32,160 --> 00:45:34,720
+least the Muslim schools at that time they should
+
+656
+00:45:34,720 --> 00:45:40,640
+have amendedالقواعد أو القواعد لتكون مناسبة
+
+657
+00:45:40,640 --> 00:45:46,360
+لحياتنا ولكن هذا لم يحدث وقال حياتنا كانت مشكلة
+
+658
+00:45:46,360 --> 00:45:51,360
+كانت صعبة فقط أخذها كما هي باستخدام التكنولوجيا في
+
+659
+00:45:51,360 --> 00:45:57,860
+أوروبا و أخذها في الشرق الأوسطو حتى هذه الوضعية ..
+
+660
+00:45:57,860 --> 00:46:01,400
+انظر لهذه النقطة .. هذه الوضعية .. هذه الفكرة ..
+
+661
+00:46:01,400 --> 00:46:06,020
+لازم تستخدمها حتى الآن .. لازم .. بعض العلماء ..
+
+662
+00:46:06,020 --> 00:46:10,260
+بعض المفهوم في القانون .. لازم يؤمنوا أن هذه هي
+
+663
+00:46:10,260 --> 00:46:13,320
+الطريقة الأفضل .. لماذا لا نأخذها من الشمس؟ مثل ..
+
+664
+00:46:13,320 --> 00:46:16,880
+أعرف بعض المدرسات .. بعض المدرسات القانونية اليوم
+
+665
+00:46:16,880 --> 00:46:20,000
+.. يعتقدون أن القانون الأوروبي هو القانون الأفضل
+
+666
+00:46:20,000 --> 00:46:28,150
+.. يجب أن نأخذه كما هو .. شخص .. شخص كان ..كان عام
+
+667
+00:46:28,150 --> 00:46:34,130
+سنة قبل قليل يحاول أن يصنع قانون مع مجلس في البلد
+
+668
+00:46:34,130 --> 00:46:36,250
+من البلد من البلد من البلد من البلد من البلد من
+
+669
+00:46:36,250 --> 00:46:36,830
+البلد من البلد من البلد من البلد من البلد من البلد
+
+670
+00:46:36,830 --> 00:46:37,050
+من البلد من البلد من البلد من البلد من البلد من
+
+671
+00:46:37,050 --> 00:46:37,070
+من البلد من البلد من البلد من البلد من البلد من
+
+672
+00:46:37,070 --> 00:46:37,750
+البلد من البلد من البلد من البلد من البلد من البلد
+
+673
+00:46:37,750 --> 00:46:37,790
+من البلد من البلد من البلد من البلد من البلد من
+
+674
+00:46:37,790 --> 00:46:37,850
+البلد من البلد من البلد من البلد من البلد من البلد
+
+675
+00:46:37,850 --> 00:46:43,130
+من البلد من البلد من
+
+676
+00:46:43,130 --> 00:46:45,570
+البلد من البلد
+
+677
+00:46:55,810 --> 00:46:59,130
+هذا ليس صحيح و ليس طريقة جيدة لأن ما علينا أن
+
+678
+00:46:59,130 --> 00:47:05,630
+نفعله هو أن نتعامل بحاجاتنا لنرى ماذا نحتاجه و
+
+679
+00:47:05,630 --> 00:47:12,970
+بعدها نستطيع أن نصنع طريقة نفسنا مرة أخرى أحتاج
+
+680
+00:47:12,970 --> 00:47:16,450
+شخص ما يقوم بالقراءة هنا شخص ما .. ماذا؟ كاولي
+
+681
+00:47:16,450 --> 00:47:23,130
+برشريا كان رجيما مع الكثير من الأدوات التي كانت
+
+682
+00:47:23,130 --> 00:47:24,530
+تعتبر أساسيا لعملها بشكل صحيح
+
+683
+00:47:31,370 --> 00:47:35,010
+however we say that if you look look here look at
+
+684
+00:47:35,010 --> 00:47:40,110
+this point here شريعة was and still a main element
+
+685
+00:47:40,110 --> 00:47:44,250
+for all aspects of our life again many elements
+
+686
+00:47:44,250 --> 00:47:47,670
+considered essential for proper functioning
+
+687
+00:47:47,670 --> 00:47:53,310
+because three main points number one شريعة based
+
+688
+00:47:53,310 --> 00:47:58,640
+on certaintyFlexibility number two وPragmatism
+
+689
+00:47:58,640 --> 00:48:03,220
+Consistent with our needs and our realistic life
+
+690
+00:48:03,220 --> 00:48:07,300
+Consistent with flexibility and certainty And it's
+
+691
+00:48:07,300 --> 00:48:11,260
+based on these So it's suitable for all times, for
+
+692
+00:48:11,260 --> 00:48:15,240
+all people, suitable for any situation And we have
+
+693
+00:48:15,240 --> 00:48:18,420
+the flexibility In Islam people think that Islam
+
+694
+00:48:18,420 --> 00:48:22,920
+is something solid, something hardلأ، ليس كذلك،
+
+695
+00:48:22,920 --> 00:48:28,300
+إنه مستقل، مستقل لتنافس بحاجاتنا، لذلك باستخدام
+
+696
+00:48:28,300 --> 00:48:34,740
+هذه الثلاث نقطة، نستطيع أن نقول إن الإسلام مناسب
+
+697
+00:48:34,740 --> 00:48:42,380
+لكل وقت، لكل حالة، و لكل إنسان إنسان، والصفحة
+
+698
+00:48:42,380 --> 00:48:48,920
+الأخيرة التي لدينا اليوم هي
+
+699
+00:48:48,920 --> 00:48:54,880
+الشريعة أكثر من مناسبةit's more than a liquid and
+
+700
+00:48:54,880 --> 00:48:59,100
+we still use it and even though people have
+
+701
+00:48:59,100 --> 00:49:02,240
+abandoned they're not using it anymore in many
+
+702
+00:49:02,240 --> 00:49:05,420
+places but we do have some people in some
+
+703
+00:49:05,420 --> 00:49:13,440
+societies they still use الشريعوي significant to
+
+704
+00:49:13,440 --> 00:49:16,980
+facilitate commerce facilitate business at least
+
+705
+00:49:16,980 --> 00:49:18,020
+we have to extract
+
+706
+00:49:22,050 --> 00:49:26,570
+نحتاج لنقوم باستخدام الواقع و نحتاج لنقوم باستخدام
+
+707
+00:49:26,570 --> 00:49:26,830
+الواقع و نحتاج لنقوم باستخدام الواقع و نحتاج لنقوم
+
+708
+00:49:26,830 --> 00:49:29,150
+باستخدام الواقع و نحتاج لنقوم باستخدام الواقع و
+
+709
+00:49:29,150 --> 00:49:30,290
+نحتاج لنقوم باستخدام
+
+710
+00:49:32,280 --> 00:49:34,380
+in istanbul if you look at sale for example sale
+
+711
+00:49:34,380 --> 00:49:38,980
+most contracts we make in our life are sale how
+
+712
+00:49:38,980 --> 00:49:42,180
+many times do you buy how many times do you buy we
+
+713
+00:49:42,180 --> 00:49:46,000
+don't call it buying contract sale contract sale
+
+714
+00:49:46,000 --> 00:49:50,200
+or contract of sale how many times per week do you
+
+715
+00:49:50,200 --> 00:49:54,900
+make sale do you buy everyday you buy clothes food
+
+716
+00:49:54,900 --> 00:50:01,490
+drink other activities you pay for them evenbuying
+
+717
+00:50:01,490 --> 00:50:05,050
+.. in Islam we have the best way in Islam to deal
+
+718
+00:50:05,050 --> 00:50:07,630
+with the sale contract and even financial
+
+719
+00:50:07,630 --> 00:50:10,870
+instruments .. financial instruments and
+
+720
+00:50:10,870 --> 00:50:16,170
+partnerships .. partnership شركات .. companies ..
+
+721
+00:50:16,170 --> 00:50:21,310
+the bases are exist .. bases exist in Islam but we
+
+722
+00:50:21,310 --> 00:50:27,640
+have to establish them in a specific bookthis one
+
+723
+00:50:27,640 --> 00:50:29,860
+point here at the end before we finish which is
+
+724
+00:50:29,860 --> 00:50:33,520
+the customs again we had last time last lecture I
+
+725
+00:50:33,520 --> 00:50:36,660
+did focus somehow on the customs the traditions
+
+726
+00:50:36,660 --> 00:50:40,680
+today again even in Islam the focus on the customs
+
+727
+00:50:40,680 --> 00:50:46,100
+how how how Islamic law focus on the customs of
+
+728
+00:50:46,100 --> 00:50:51,920
+people anyone
+
+729
+00:50:52,520 --> 00:51:01,260
+أنا سأشرحك بشأن كتابة الفقه الشريعيين والمدرسين
+
+730
+00:51:01,260 --> 00:51:05,540
+وما قالوه نحن نعرف أن أكتر الناس الآن أكتر البلدين
+
+731
+00:51:05,540 --> 00:51:08,520
+أكتر البلدين المسلمين لديها تخلصوا من القوة
+
+732
+00:51:08,520 --> 00:51:10,960
+الشريعية أو القوة الإسلامية ولكن في نفس الوقت
+
+733
+00:51:10,960 --> 00:51:13,820
+انظروا إلى المجتمعات انظروا إلى بلستان في أيجاب
+
+734
+00:51:13,820 --> 00:51:17,180
+جوردان باكستان في العديد من البلدان في العالم
+
+735
+00:51:17,180 --> 00:51:21,020
+الإسلامي ستجدوا أن هذه المجتمعات تتخلصوا من القوة
+
+736
+00:51:21,020 --> 00:51:26,970
+الإسلاميةولا أشعر حتى بذلك، عملياتنا، ماذا ترتدي؟
+
+737
+00:51:26,970 --> 00:51:31,530
+كيف تفعل؟ كيف تتعامل مع الناس؟ كيف تعمل في
+
+738
+00:51:31,530 --> 00:51:36,530
+المجتمع؟ هذه العمليات متوافقة مع القوة الإسلامية،
+
+739
+00:51:36,530 --> 00:51:41,700
+أليس كذلك؟هل عاداتنا و عاداتنا و عاداتنا و عاداتنا
+
+740
+00:51:41,700 --> 00:51:42,320
+و عاداتنا و عاداتنا و عاداتنا و عاداتنا و عاداتنا
+
+741
+00:51:42,320 --> 00:51:44,220
+و عاداتنا و عاداتنا و عاداتنا و عاداتنا و عاداتنا
+
+742
+00:51:44,220 --> 00:51:45,240
+و عاداتنا و عاداتنا و عاداتنا و عاداتنا و عاداتنا
+
+743
+00:51:45,240 --> 00:51:47,320
+و عاداتنا و عاداتنا و عاداتنا و عاداتنا و عاداتنا
+
+744
+00:51:47,320 --> 00:51:51,360
+و عاداتنا و عاداتنا و عاداتنا و عاداتنا و عاداتنا
+
+745
+00:51:51,360 --> 00:51:51,540
+و عاداتنا و عاداتنا و عاداتنا و عاداتنا و عاداتنا
+
+746
+00:51:51,540 --> 00:51:53,840
+و عاداتنا و عاداتنا و عاداتنا و عاداتنا و عاداتنا
+
+747
+00:51:53,840 --> 00:51:58,260
+و عاداتنا و عاداتنا و عاداتنا و عاداتنا و عاداتنا
+
+748
+00:51:58,260 --> 00:52:08,520
+و عادإذا اتفقنا أننا لدينا اجمال في مجتمعنا، يعني
+
+749
+00:52:08,520 --> 00:52:12,540
+أن ما نفعله صحيح. لا يمكننا أن نكون لدينا اجمال
+
+750
+00:52:12,540 --> 00:52:17,360
+على خطأ. لا يمكننا .. لا يمكننا أن جميعنا نفعل نفس
+
+751
+00:52:17,360 --> 00:52:24,340
+الخطأ. لا. و .. الوضع الأخير، الانهيار الإسلامي
+
+752
+00:52:24,340 --> 00:52:27,580
+اللي لدينا هنا اليوم، في الكثير من المكان، انت ترى
+
+753
+00:52:27,580 --> 00:52:35,050
+كم مجتمع إسلامي، كم مجموعة إسلاميهو في السنوات
+
+754
+00:52:35,050 --> 00:52:38,890
+الماضية كم عدد المدارس الإسلامية أو المدارس
+
+755
+00:52:38,890 --> 00:52:41,990
+المسلمين كانوا يطلبوا أن يتخلصوا من القوة
+
+756
+00:52:41,990 --> 00:52:48,990
+الإسلامية من جمهور المجتمع ومن البلد وكم من
+
+757
+00:52:48,990 --> 00:52:53,810
+المدارس الأسطورية حيث ذكروا عدة مرات أن الإسلام هو
+
+758
+00:52:53,810 --> 00:52:58,510
+الطريقة الأفضل لتحفظ المجتمعين في طريقة أفضل و
+
+759
+00:52:58,510 --> 00:53:04,630
+آمنةلذلك نؤمن بأن جمعية الشريعة
+
+760
+00:53:08,550 --> 00:53:12,030
+والبرنامج المكمل لشركة شرق أمريكا، يحتاج إلى
+
+761
+00:53:12,030 --> 00:53:17,870
+استخدام المجالات التجارية لكي نحصل على حياة مجالات
+
+762
+00:53:17,870 --> 00:53:20,950
+تجارية جيدة، حياة شركة، ومجالات التخزين ومجالات
+
+763
+00:53:20,950 --> 00:53:21,050
+التخزين ومجالات التخزين ومجالات التخزين ومجالات
+
+764
+00:53:21,050 --> 00:53:21,610
+التخزين ومجالات التخزين ومجالات التخزين ومجالات
+
+765
+00:53:21,610 --> 00:53:22,870
+التخزين ومجالات التخزين ومجالات التخزين ومجالات
+
+766
+00:53:22,870 --> 00:53:24,770
+التخزين ومجالات التخزين ومجالات التخزين ومجالات
+
+767
+00:53:24,770 --> 00:53:28,270
+التخزين ومجالات التخزين ومجالات التخزين ومجالات
+
+768
+00:53:28,270 --> 00:53:36,230
+التخزين ومجال
+
diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/unzS5NLj5Xg_raw.srt b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/unzS5NLj5Xg_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..2a35b869c33a8d9c89de2dddb969870385b59b6e
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/unzS5NLj5Xg_raw.srt
@@ -0,0 +1,3400 @@
+1
+00:00:10,540 --> 00:00:16,540
+بسم الله الرحمن الرحيم this lecture is the second
+
+2
+00:00:16,540 --> 00:00:20,560
+lecture about contracts last time we had the
+
+3
+00:00:20,560 --> 00:00:24,240
+conditions of the contract in which we have to
+
+4
+00:00:24,240 --> 00:00:28,390
+look at the ways to establish contractsوخاصة ما
+
+5
+00:00:28,390 --> 00:00:33,430
+لدينا ثلاثة حاجات الرئيسية ثلاثة أسلوب لإنشاء
+
+6
+00:00:33,430 --> 00:00:37,990
+مقاومة رقم واحد كان اعطاء اقناطية رقم اثنان هو
+
+7
+00:00:37,990 --> 00:00:43,750
+التفكير وهو قيمته ورقم ثلاثة هو الهدف لكي تكون
+
+8
+00:00:43,750 --> 00:00:46,870
+قادرا على القانون الواضح انه بعض الأحيان لدينا
+
+9
+00:00:46,870 --> 00:00:52,490
+حاجة اضافية تسمى فرماليتيز هذا سننظر عليه لاحقا
+
+10
+00:00:52,490 --> 00:00:58,760
+ولكن على الأقل لانه يجب أن نبدأ مع الهدفbehind any
+
+11
+00:00:58,760 --> 00:01:03,460
+action you make behind any transaction you do you
+
+12
+00:01:03,460 --> 00:01:06,300
+have intention if you do not have the intention
+
+13
+00:01:06,300 --> 00:01:12,000
+means it means that you have done no activity your
+
+14
+00:01:12,000 --> 00:01:18,560
+act will be worthless will not constitute any
+
+15
+00:01:18,560 --> 00:01:21,920
+activity any legal activity in a contractعندما
+
+16
+00:01:21,920 --> 00:01:24,180
+تقوم بعمل هذا على مبادرة يومية أو أسبوع يومية أو
+
+17
+00:01:24,180 --> 00:01:25,560
+أسبوع يومية أو أسبوع يومية أو أسبوع يومية او أسبوع
+
+18
+00:01:25,560 --> 00:01:26,460
+يومية او أسبوع يومية او أسبوع يومية او أسبوع يومية
+
+19
+00:01:26,460 --> 00:01:28,080
+او أسبوع يومية او أسبوع يومية او أسبوع يومية او
+
+20
+00:01:28,080 --> 00:01:29,720
+أسبوع يومية او أسبوع يومية او أسبوع يومية او أسبوع
+
+21
+00:01:29,720 --> 00:01:30,320
+يومية او أسبوع يومية او أسبوع يومية او أسبوع يومية
+
+22
+00:01:30,320 --> 00:01:31,840
+او أسبوع يومية او أسبوع يومية او أسبوع يومية او
+
+23
+00:01:31,840 --> 00:01:34,300
+أسبوع يومية او أسبوع يومية او أسبوع يومية او أسبوع
+
+24
+00:01:34,300 --> 00:01:38,560
+يومية او
+
+25
+00:01:38,560 --> 00:01:45,900
+أسبوع يومية او
+
+26
+00:01:48,750 --> 00:01:52,890
+أفعل ما سأفعله بالضبط، يجب أن أعطي المال أو
+
+27
+00:01:52,890 --> 00:01:56,550
+الجمهور أو أن أفعل شيء آخر لإعطاء خدمة، إنها
+
+28
+00:01:56,550 --> 00:02:04,330
+مقرارة تأتي من الإقناع والهدف يجب أن نعتمد في كل
+
+29
+00:02:04,330 --> 00:02:09,110
+موقع في كل مقرارات أن لدينا هدف إلا إذا كان واحد
+
+30
+00:02:09,110 --> 00:02:13,830
+من الجمهورين يثبت أنه أو انها لم يكن لديه هدفأنا
+
+31
+00:02:13,830 --> 00:02:16,190
+أستطيع أن أقول أن جميعكم الذين قموا بالدراسة
+
+32
+00:02:16,190 --> 00:02:20,490
+اليوم، قموا بالدراسة، استمعوا لي، تنظروا لي و
+
+33
+00:02:20,490 --> 00:02:24,750
+لديكم الهدف أن تقوموا بالدراسة، لا أحد يجعلكم ..
+
+34
+00:02:24,750 --> 00:02:29,890
+ربما بعضكم قموا بالدراسة و لم تحبها، لكن على الأقل
+
+35
+00:02:29,890 --> 00:02:33,770
+أستطيع أن أقول أن أكتر منكم قموا بالدراسة لأنكم
+
+36
+00:02:33,770 --> 00:02:40,660
+لديكم الهدف، حتى لو لم تحبونه لأنه صعب قليلاأنت
+
+37
+00:02:40,660 --> 00:02:44,340
+لديك الهدف ليس كل ما نفعله في حياتنا لديه هدف
+
+38
+00:02:44,340 --> 00:02:49,460
+أحيانا الناس تفعل أشياء ولكنها ليست لديها أي هدف
+
+39
+00:02:49,460 --> 00:02:53,500
+لتفعلها انت فقط تشعر أنك يجب أن تفعل شيء انها
+
+40
+00:02:53,500 --> 00:02:57,520
+رتينية انها رتينية أساسية للحياة الآن لتقوم بنفسك
+
+41
+00:02:57,520 --> 00:03:01,040
+بطريقة قانونية انها ليست رتينية انها شيء يجب أن
+
+42
+00:03:01,040 --> 00:03:05,600
+يكون فعله باعتبار للنظام القانوني اللي هو الوضع
+
+43
+00:03:05,600 --> 00:03:13,330
+رقم اتنين اتنينالجمهورين يجب ان يكونوا قادرين على
+
+44
+00:03:13,330 --> 00:03:13,410
+أن يكونوا قادرين على أن يكونوا قادرين على أن
+
+45
+00:03:13,410 --> 00:03:13,850
+يكونوا قادرين على أن يكونوا قادرين على أن يكونوا
+
+46
+00:03:13,850 --> 00:03:14,310
+قادرين على أن يكونوا قادرين على أن يكونوا قادرين
+
+47
+00:03:14,310 --> 00:03:15,830
+على أن يكونوا قادرين على أن يكونوا قادرين على أن
+
+48
+00:03:15,830 --> 00:03:16,250
+يكونوا قادرين على أن يكونوا قادرين على أن يكونوا
+
+49
+00:03:16,250 --> 00:03:17,350
+قادرين على أن يكونوا قادرين على أن يكونوا قادرين
+
+50
+00:03:17,350 --> 00:03:17,370
+على أن يكونوا قادرين على أن يكونوا قادرين على أن
+
+51
+00:03:17,370 --> 00:03:18,650
+يكونوا قادرين على أن يكونوا قادرين على أن يكونوا
+
+52
+00:03:18,650 --> 00:03:21,550
+قادرين على أن يكونوا قادرين على أن يكونوا قادرين
+
+53
+00:03:21,550 --> 00:03:25,150
+على أن يكونوا قادرين على أن يكونوا قادرين
+
+54
+00:03:27,350 --> 00:03:30,230
+commitments commitments but these commitments do
+
+55
+00:03:30,230 --> 00:03:33,190
+not come from the contract there is no intention
+
+56
+00:03:33,190 --> 00:03:37,110
+there is no legal contract i commit myself to help
+
+57
+00:03:37,110 --> 00:03:40,990
+my family at home i commit myself to help some of
+
+58
+00:03:40,990 --> 00:03:44,470
+my friends but this commitment does not come from
+
+59
+00:03:44,470 --> 00:03:48,090
+a legal contract it comes from ethics humanity
+
+60
+00:03:48,090 --> 00:03:51,170
+from my own personal side it's not a commitment
+
+61
+00:03:51,170 --> 00:03:54,770
+has to be enforced by law no it's not we have an
+
+62
+00:03:54,770 --> 00:03:58,110
+exampleالتي حدثت في الولايات المتحدة قبل وقت طويل
+
+63
+00:03:58,110 --> 00:04:04,590
+و في الواقع انها تأثير قانوني و المدرسين اللي
+
+64
+00:04:04,590 --> 00:04:08,570
+قابلوا أسبوع الأول معي هنا اكسبلين تتذكر ان
+
+65
+00:04:08,570 --> 00:04:13,230
+اكسبلين هو معنى قانون معين و قد قلت قانون معين
+
+66
+00:04:13,230 --> 00:04:18,910
+يعتمد على تأثير قانوني القانون مجرد الحجر القضاء
+
+67
+00:04:18,910 --> 00:04:25,870
+صواب القضايا هذا واحد من القضاءبالفور vs بالفور
+
+68
+00:04:25,870 --> 00:04:32,690
+بالفور مرة أخرى هو بالفور رجل و زوجته كان
+
+69
+00:04:32,690 --> 00:04:37,170
+يعطي زوجته المال عشان أشهر و أشهر ثلاثة عشان عشان
+
+70
+00:04:37,170 --> 00:04:38,070
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+71
+00:04:38,070 --> 00:04:40,970
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+72
+00:04:40,970 --> 00:04:42,830
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+73
+00:04:42,830 --> 00:04:43,210
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+74
+00:04:43,210 --> 00:04:45,930
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+75
+00:04:45,930 --> 00:04:50,790
+عشان عشان عشان عشان
+
+76
+00:04:50,790 --> 00:04:57,280
+عشانو على مدى شهر كان يرسل زوجته 30 باونز بعد وقت
+
+77
+00:04:57,280 --> 00:05:02,240
+.. بعد وقت .. هم اختلافوا .. اتفرجوا .. هم رحلوا
+
+78
+00:05:02,240 --> 00:05:05,900
+بعضهم البعض الان الراجل توقف عن اعطاء زوجته لانها
+
+79
+00:05:05,900 --> 00:05:09,340
+ليست زوجته بعد الان ليس مقرر معها بعد الان في
+
+80
+00:05:09,340 --> 00:05:15,060
+البداية كان يعطيها اعطاء عائلة اعطاء عائلة عائلة
+
+81
+00:05:15,060 --> 00:05:15,100
+عائلة عائلة عائلة عائلة عائلة عائلة عائلة عائلة
+
+82
+00:05:15,100 --> 00:05:15,180
+عائلة عائلة عائلة عائلة عائلة عائلة عائلة عائلة
+
+83
+00:05:15,180 --> 00:05:15,640
+عائلة عائلة عائلة عائلة عائلة عائلة عائلة عائلة
+
+84
+00:05:15,640 --> 00:05:16,500
+عائلة عائلة عائلة عائلة عائلة عائلة عائلة عائلة
+
+85
+00:05:16,500 --> 00:05:20,940
+عائلة عائلة عائ
+
+86
+00:05:21,370 --> 00:05:23,650
+تبقى في هذه الحالة طوال الوقت طوال الوقت طوال
+
+87
+00:05:23,650 --> 00:05:25,030
+الوقت طوال الوقت طوال الوقت طوال الوقت طوال الوقت
+
+88
+00:05:25,030 --> 00:05:26,690
+طوال الوقت طوال الوقت طوال الوقت طوال الوقت طوال
+
+89
+00:05:26,690 --> 00:05:29,450
+الوقت طوال الوقت طوال الوقت طوال الوقت طوال الوقت
+
+90
+00:05:29,450 --> 00:05:30,370
+طوال الوقت طوال الوقت طوال الوقت طوال الوقت طوال
+
+91
+00:05:30,370 --> 00:05:30,910
+الوقت طوال الوقت طوال الوقت طوال الوقت طوال الوقت
+
+92
+00:05:30,910 --> 00:05:32,190
+طوال الوقت طوال الوقت طوال الوقت طوال الوقت طوال
+
+93
+00:05:32,190 --> 00:05:36,630
+الوقت طوال الوقت طوال الوقت طوال الوقت
+
+94
+00:05:39,270 --> 00:05:42,710
+كان يطلب من المدفعات أن تكون مستمرة طوال الوقت
+
+95
+00:05:42,710 --> 00:05:46,270
+والرجل اقفز وقال انا لا أستطيع أن أدفع لها لأنني
+
+96
+00:05:46,270 --> 00:05:50,390
+لم أقوم نفسي لأني ليس لدي اهتمام انها ليست شرطة
+
+97
+00:05:50,390 --> 00:05:54,070
+انا لدي افارقة لأعطيها 30 دولار في الشهر وكانت
+
+98
+00:05:54,070 --> 00:05:59,470
+تقبل هذه الافارقة انا لم اكن لدي اهتمام في عقلي
+
+99
+00:05:59,470 --> 00:06:06,380
+لأقوم نفسي في شرطة لم يكن هناك شرطةهذا الحكومة
+
+100
+00:06:06,380 --> 00:06:11,660
+ذهبت إلى محكمة قبيل قبيل قبيل قبيل قبيل قبيل قبيل
+
+101
+00:06:11,660 --> 00:06:17,420
+قبيل قبيل قبيل قبيل قبيل قبيل قبيل قبيل قبيل قبيل
+
+102
+00:06:17,420 --> 00:06:20,300
+قبيل قبيل قبيل قبيل قبيل قبيل
+
+103
+00:06:21,990 --> 00:06:27,090
+unenforceable نحن لدينا فرصة فرصة ليس فرصة فرصة
+
+104
+00:06:27,090 --> 00:06:33,670
+لأنه لم يكن هناك اهتمام لم يكن هناك اهتمام حتى وان
+
+105
+00:06:33,670 --> 00:06:38,370
+كلاهم اقبلوا وفعلوا اهتمامهم طوال الوقت بعضهم
+
+106
+00:06:38,370 --> 00:06:42,250
+بعضهم يدفعون والثاني يحصل على المال ولكن لم يكن
+
+107
+00:06:42,250 --> 00:06:45,530
+هناك اهتمام لإنهاء نفسهم بشكل صحيح
+
+108
+00:06:48,730 --> 00:06:53,070
+هذا ما يسمى اهتمام انا اعتقد انه واضح انه ليس صعب
+
+109
+00:06:53,070 --> 00:06:57,350
+ان تفهم كيف يمكننا ان نكون مهتمين انه اهتمام مجاني
+
+110
+00:06:57,350 --> 00:07:03,830
+ليس بشيء بقوة لدينا بعض الحالات التي سنبحث عنها
+
+111
+00:07:03,830 --> 00:07:07,590
+لاحقا في الواقع يمكننا ان نجلس خارج التجارب يمكننا
+
+112
+00:07:07,590 --> 00:07:12,350
+ان نغلق التجارب يمكننا ان نغلطها إذا كانت التجارب
+
+113
+00:07:12,350 --> 00:07:16,220
+ليس لديها اهتمام فهي لن تكون تجاربولكننا نتركها
+
+114
+00:07:16,220 --> 00:07:19,540
+حتى ذلك الوقت ولكن من الأن .. من الأن .. نستطيع أن
+
+115
+00:07:19,540 --> 00:07:23,180
+نرى أن الهدف هو أساسي .. شيء يجب أن يكون موجود
+
+116
+00:07:23,180 --> 00:07:26,660
+طوال الوقت ولكن من يستطيع أن يثبت ذلك؟ من يستطيع
+
+117
+00:07:26,660 --> 00:07:32,780
+ذلك؟ إذا قلت أني قمت بالتعامل معك ولم يكن لديه هدف
+
+118
+00:07:32,780 --> 00:07:36,880
+.. لم يكن لديه هدف .. لأنه استخدم القوة ضدي ..
+
+119
+00:07:36,880 --> 00:07:41,960
+فأنا يجب أن أثبت ذلكعندما نقوم بإصلاح شركة و نقوم
+
+120
+00:07:41,960 --> 00:07:43,380
+بإصلاح شركة و نقوم بإصلاح شركة و نقوم بإصلاح شركة
+
+121
+00:07:43,380 --> 00:07:45,540
+و نقوم بإصلاح شركة و نقوم بإصلاح شركة و نقوم
+
+122
+00:07:45,540 --> 00:07:46,240
+بإصلاح شركة و نقوم بإصلاح شركة و نقوم بإصلاح شركة
+
+123
+00:07:46,240 --> 00:07:47,580
+و نقوم بإصلاح شركة و نقوم بإصلاح شركة و نقوم
+
+124
+00:07:47,580 --> 00:07:48,300
+بإصلاح شركة و نقوم بإصلاح شركة و نقوم بإصلاح شركة
+
+125
+00:07:48,300 --> 00:07:51,980
+و نقوم بإصلاح شركة و نقوم بإصلاح شركة و نقوم
+
+126
+00:07:51,980 --> 00:07:59,740
+بإصلاح شركة و نقوم بإصلاح شركة و نقوم بإ
+
+127
+00:08:08,430 --> 00:08:13,330
+هذا في ألمانيا و أخر أمريكا في المنطقة التي هناك
+
+128
+00:08:13,330 --> 00:08:18,990
+اختلاف بين الواضحة التي قلناها قبلها لدينا موضوع و
+
+129
+00:08:18,990 --> 00:08:20,770
+لدينا مصدر
+
+130
+00:08:26,370 --> 00:08:30,370
+و كما قلت قبل ذلك لدينا A و B و Commitment و
+
+131
+00:08:30,370 --> 00:08:34,010
+Commitment و Obligation و Obligation و
+
+132
+00:08:34,010 --> 00:08:38,270
+Responsibility لازم افعل شيء لان اشتغلت العمل لازم
+
+133
+00:08:38,270 --> 00:08:43,480
+افعل شيء يمكن أن يكون يدفع المالممكن ترسم غرفة
+
+134
+00:08:43,480 --> 00:08:49,160
+ممكن تحفظ الأموال ممكن تفعل شيء مشابه لهذا الموضوع
+
+135
+00:08:49,160 --> 00:08:51,900
+لكن الجانب الثاني سيفعل شيء مختلف وهو موضوع مقرر
+
+136
+00:08:51,900 --> 00:08:56,120
+في بعض الحالات في بعض الحالات لدينا اتفاقين
+
+137
+00:08:56,120 --> 00:09:01,720
+اتفاقين اتفاقين
+
+138
+00:09:01,720 --> 00:09:06,700
+اتفاقين اتفاقين اتفاقين اتفاقين اتفاقين اتفاقين
+
+139
+00:09:06,700 --> 00:09:12,400
+اتفاقين اتفاقين اتفاقين اتفاقينوالثاني وضعف هو ال
+
+140
+00:09:12,400 --> 00:09:18,520
+title title هو سند الملكية ownership of the
+
+141
+00:09:18,520 --> 00:09:22,540
+property بعض الأشياء .. بعض الأشياء مثل أشياء
+
+142
+00:09:22,540 --> 00:09:26,360
+صغيرة و قاسية ، يمكن أن تكون ال ownership بمحافظته
+
+143
+00:09:26,360 --> 00:09:29,720
+بمحافظته مثلًا إذا كان هذا هو هاتف موبايلي كما
+
+144
+00:09:29,720 --> 00:09:33,420
+يمكنك أن ترى، يمكنك أن تقول هذا هو هاتف موبايلي
+
+145
+00:09:33,420 --> 00:09:39,170
+لأنني محافظته، أنا محافظته، إنه معيunless someone
+
+146
+00:09:39,170 --> 00:09:43,030
+else claim it someone else claim the mobile phone
+
+147
+00:09:43,030 --> 00:09:47,090
+he or she has to prove that otherwise it's mine
+
+148
+00:09:47,090 --> 00:09:51,050
+but if it's something expensive something valuable
+
+149
+00:09:51,050 --> 00:09:58,330
+like a house flat land car these and others buying
+
+150
+00:09:58,330 --> 00:10:02,770
+a company these have to be in a special form we
+
+151
+00:10:02,770 --> 00:10:05,310
+will look at this later on these have to be in a
+
+152
+00:10:05,310 --> 00:10:09,970
+specific formataccording to the law okay if those
+
+153
+00:10:09,970 --> 00:10:12,550
+will be in a specific format then we have to
+
+154
+00:10:12,550 --> 00:10:16,170
+follow the procedures not only acceptance and
+
+155
+00:10:16,170 --> 00:10:20,030
+offer not only intention with that and not devalue
+
+156
+00:10:20,030 --> 00:10:22,870
+the consideration we have to add a new condition
+
+157
+00:10:22,870 --> 00:10:26,990
+which is special format في شكل محدد special format
+
+158
+00:10:26,990 --> 00:10:31,970
+by this we have to transfer the titletitle will be
+
+159
+00:10:31,970 --> 00:10:36,590
+transferred in this case by making the contract
+
+160
+00:10:36,590 --> 00:10:42,990
+most likely in a specific form ايش عندك انت ايش
+
+161
+00:10:42,990 --> 00:10:48,790
+عندك انت ايش عندك it weird no it's not it weird no
+
+162
+00:10:48,790 --> 00:10:53,810
+it's commercial law it sounds like but it's not
+
+163
+00:11:00,280 --> 00:11:03,460
+Okay, now we separate between the two obligations.
+
+164
+00:11:04,060 --> 00:11:06,660
+We have an example to make it easy for students to
+
+165
+00:11:06,660 --> 00:11:10,040
+understand this. We have an example. The example
+
+166
+00:11:10,040 --> 00:11:16,680
+says that somebody, a man, a man was drunk and
+
+167
+00:11:16,680 --> 00:11:22,700
+someone else, bالشخص اللي كان مستخدم لهذا الوضع هو
+
+168
+00:11:22,700 --> 00:11:26,000
+شخص مستخدم لا يستطيع استخدام عقله اشخاص لا
+
+169
+00:11:26,000 --> 00:11:28,840
+يستطيعون أن يفكر لا يستطيعون ان يكونوا مستخدمين لا
+
+170
+00:11:28,840 --> 00:11:29,680
+يستطيعون ان يكونوا مستخدمين لا يستطيعون ان يكونوا
+
+171
+00:11:29,680 --> 00:11:32,180
+مستخدمين لا يستطيعون ان يكونوا مستخدمين لا
+
+172
+00:11:32,180 --> 00:11:33,280
+يستطيعون ان يكونوا مستخدمين لا يستطيعون ان يكونوا
+
+173
+00:11:33,280 --> 00:11:33,900
+مستخدمين لا يستطيعون ان يكونوا مستخدمين لا
+
+174
+00:11:33,900 --> 00:11:36,520
+يستطيعون ان يكونوا مستخدمين لا يستطيعون ان يكونوا
+
+175
+00:11:36,520 --> 00:11:40,400
+مستخدمين
+
+176
+00:11:40,400 --> 00:11:43,680
+لا يستطيعون ان يكونوا مستخدمين لا يستطيعون ان
+
+177
+00:11:43,680 --> 00:11:50,800
+يكونوا مستخدمين لا يستطيعون انلذلك A كان محببا و
+
+178
+00:11:50,800 --> 00:11:54,420
+كان لديه المال و
+
+179
+00:11:54,420 --> 00:12:03,600
+اشتريت سيارة السيارة بي كانت السيارة بي
+
+180
+00:12:03,600 --> 00:12:07,300
+كانت السيارة بي كانت السيارة بي كانت السيارة بي
+
+181
+00:12:07,300 --> 00:12:08,080
+كانت السيارة بي كانت السيارة بي كانت السيارة بي
+
+182
+00:12:08,080 --> 00:12:08,440
+كانت السيارة بي كانت السيارة بي كانت السيارة بي
+
+183
+00:12:08,440 --> 00:12:08,460
+كانت السيارة بي كانت السيارة بي كانت السيارة بي
+
+184
+00:12:08,460 --> 00:12:08,780
+كانت السيارة بي كانت السيارة بي كانت السيارة بي
+
+185
+00:12:08,780 --> 00:12:12,660
+كانت السيارة بي كانت السيارة بي كانت السيارة بي
+
+186
+00:12:12,660 --> 00:12:16,680
+كانت السيارة بي كانت السيارة بي كانت السيارة بي
+
+187
+00:12:16,680 --> 00:12:20,390
+كانت السيارة بي كانت السيارة بلذلك لا يمكنه أن
+
+188
+00:12:20,390 --> 00:12:22,970
+يفكر ولا يمكنه أن يقرر اي قرار ولكنه فعلت ذلك
+
+189
+00:12:22,970 --> 00:12:28,530
+المجلد الثاني A يعتقد أنه كان بخير يمكنني استخدام
+
+190
+00:12:28,530 --> 00:12:33,270
+هذه الحالة و بعد ذلك جعله يقوم بتقرار شراء السيارة
+
+191
+00:12:33,270 --> 00:12:36,610
+ثم
+
+192
+00:12:36,610 --> 00:12:37,890
+بعد ذلك B
+
+193
+00:12:40,400 --> 00:12:43,860
+awaken up look at the situation found himself
+
+194
+00:12:43,860 --> 00:12:47,760
+signed a contract to buy a car now when you signed
+
+195
+00:12:47,760 --> 00:12:50,240
+a contract in a special form most likely it's not
+
+196
+00:12:50,240 --> 00:12:52,600
+most likely let's say the situation would be the
+
+197
+00:12:52,600 --> 00:12:56,640
+the property the title the title will be
+
+198
+00:12:56,640 --> 00:13:00,840
+transferred from one to the other the title هو
+
+199
+00:13:00,840 --> 00:13:05,820
+الملكية the title is transferred from a to b a to
+
+200
+00:13:05,820 --> 00:13:10,580
+b but then a did not pay the money yetهو لم يدفع
+
+201
+00:13:10,580 --> 00:13:14,440
+المال لم يحاول و لم يدفع المال لا أحد يمكن يجعله
+
+202
+00:13:14,440 --> 00:13:17,640
+يدفع المال لا أحد يمكن يجعله يدفع المال و لا أحد
+
+203
+00:13:17,640 --> 00:13:17,640
+يجعله يدفع المال و لا أحد يجعله يدفع المال و لا
+
+204
+00:13:17,640 --> 00:13:17,640
+أحد يجعله يدفع المال و لا أحد يجعله يدفع المال و
+
+205
+00:13:17,640 --> 00:13:17,640
+لا أحد يجعله يدفع المال و لا أحد يجعله يدفع المال
+
+206
+00:13:17,640 --> 00:13:17,780
+و لا أحد يجعله يدفع المال و لا أحد يجعله يدفع
+
+207
+00:13:17,780 --> 00:13:19,140
+المال و لا أحد يجعله يدفع المال و لا أحد يجعله
+
+208
+00:13:19,140 --> 00:13:25,260
+يدفع المال و لا أحد يجعله يدفع المال و لا أحد
+
+209
+00:13:25,260 --> 00:13:34,980
+يجعله يدفع المال و لا
+
+210
+00:13:34,980 --> 00:13:35,040
+أحد
+
+211
+00:13:46,450 --> 00:13:54,510
+انا المالك انا المالك انا المالك انا
+
+212
+00:13:54,510 --> 00:13:59,470
+المالك
+
+213
+00:13:59,470 --> 00:14:05,070
+of that item this title has to be transferred back
+
+214
+00:14:05,070 --> 00:14:10,600
+to the ownerيمكن أن يكون بعض الوقت المنافسة يمكن
+
+215
+00:14:10,600 --> 00:14:14,320
+أن يكون بعض الوقت المالك بالسيارة و هو الشخص اللي
+
+216
+00:14:14,320 --> 00:14:19,020
+شربه و شخص أخر قام بالاستخدام من هذه اللحظة بشراء
+
+217
+00:14:19,020 --> 00:14:25,140
+سيارته و يدفع فقط نصف السعر يدفع فقط أقل من 50% من
+
+218
+00:14:25,140 --> 00:14:29,140
+سعر السيارة في هذه الحالة يمكنك أن تأخذ سيارتك مرة
+
+219
+00:14:29,140 --> 00:14:31,860
+أخرى يمكنك أن تنهي هذا التواصل يمكنك أن تسحب بين
+
+220
+00:14:31,860 --> 00:14:38,640
+موقعك و مقعدك انا فعلت مقعدعملت وضع نفسي و كان لدي
+
+221
+00:14:38,640 --> 00:14:45,300
+وضع وضع وضع وضع وضع وضع وضع وضع وضع وضع وضع وضع
+
+222
+00:14:45,300 --> 00:14:53,180
+وضع وضع وضع وضع وضع وضع وضع وضع وضع وضع وضع وضع
+
+223
+00:15:07,500 --> 00:15:09,820
+it's not really easy to prove that someone is
+
+224
+00:15:09,820 --> 00:15:13,940
+blind yes this is a different case most students
+
+225
+00:15:13,940 --> 00:15:16,940
+asking the same questions all the time that how is
+
+226
+00:15:16,940 --> 00:15:20,280
+it gonna be would it be easy to prove can we have
+
+227
+00:15:20,280 --> 00:15:23,840
+an evidence but this is not commercial law this is
+
+228
+00:15:23,840 --> 00:15:27,760
+a procedural law now we assume in all cases that
+
+229
+00:15:27,760 --> 00:15:31,750
+we have all the evidenceهو ما كان محتاجا لهذا
+
+230
+00:15:31,750 --> 00:15:35,770
+الحالة و اعتقدنا ان كلا الحكومات A وB كل واحدة
+
+231
+00:15:35,770 --> 00:15:39,250
+منهم قامت بإرسال الوثيقة المتوفرة و كان يجب أن
+
+232
+00:15:39,250 --> 00:15:43,170
+يكون الحكومة تقوم باختيار خاصة في الأعمال التجارية
+
+233
+00:15:48,490 --> 00:15:51,310
+لأنهم قد فعلوا ذلك بالفعل و انا اعرف انه صعب و ليس
+
+234
+00:15:51,310 --> 00:15:54,710
+بسهولة كيف اعرف اذا كان شخص ما لديه اهتمام او لا؟
+
+235
+00:15:54,710 --> 00:15:59,470
+نستطيع أن نعرف بمشاهدة الوضع كله و اشيائه نستطيع
+
+236
+00:15:59,470 --> 00:16:02,590
+أن نعرف .. انا أستطيع ان افهم ان اذا شخص .. شخص
+
+237
+00:16:02,590 --> 00:16:06,090
+جاء لدراسة دراسة لتدرس و لتقوم بمواصلة و لتكون
+
+238
+00:16:06,090 --> 00:16:11,950
+مواصلة انا اعرف اشخاص طفلين يأتيون لدراسة ولكن يجب
+
+239
+00:16:11,950 --> 00:16:15,840
+ان يفعلوا ذلكلديهم لا اختيارات ولكن إذا وجدوا
+
+240
+00:16:15,840 --> 00:16:18,640
+اختيار أخر لن يأتيوا إلى هنا يمكنك أن تقول من
+
+241
+00:16:18,640 --> 00:16:23,080
+الوصفات إذا كان شخص يريد أن يشتري .. شخص سيشتري
+
+242
+00:16:23,080 --> 00:16:28,880
+سيارة و كل ما لديه فقط ألف دولار و سيارة جميلة ..
+
+243
+00:16:28,880 --> 00:16:31,960
+سيارة جميلة تكلف 10 ألف دولار و الان ليس لديه
+
+244
+00:16:31,960 --> 00:16:35,840
+اختيار ولكن لكي تشتري هذه السيارة التي تكلف 1 ألف
+
+245
+00:16:35,840 --> 00:16:38,540
+دولار ولكن إذا كان هذا الشخص لديه الكثير من المال
+
+246
+00:16:38,540 --> 00:16:43,080
+فهو سيشتري ما يريدI'm talking about indications I
+
+247
+00:16:43,080 --> 00:16:46,520
+can tell like for example how can I tell how can I
+
+248
+00:16:46,520 --> 00:16:52,620
+tell if someone is a merchant or not merchant by
+
+249
+00:16:52,620 --> 00:16:55,280
+looking at that person like I have a laptop I
+
+250
+00:16:55,280 --> 00:16:59,180
+would like to sell this is an indication that is a
+
+251
+00:16:59,180 --> 00:17:03,620
+civilian act it's my personal but if I have 20 PCs
+
+252
+00:17:03,620 --> 00:17:08,800
+or 20 mobile phonesانا وانتو ال market to sell the
+
+253
+00:17:08,800 --> 00:17:11,480
+twenty mobile phones is that do you think this is
+
+254
+00:17:11,480 --> 00:17:14,500
+civil or commercial activity commercial because of
+
+255
+00:17:14,500 --> 00:17:18,700
+the amount look at the amount how many items this
+
+256
+00:17:18,700 --> 00:17:21,320
+is kind of indications we look at the amount we
+
+257
+00:17:21,320 --> 00:17:25,860
+look at the type look at the type like somebody
+
+258
+00:17:25,860 --> 00:17:29,760
+buying a ship why should I need a ship what's for
+
+259
+00:17:29,760 --> 00:17:33,220
+as a teacher at university it might be because I
+
+260
+00:17:33,220 --> 00:17:38,800
+want it to use it to for cargoit's not like using
+
+261
+00:17:38,800 --> 00:17:41,140
+it as personal at personal level you know looking
+
+262
+00:17:41,140 --> 00:17:43,400
+at the type of the goods and the items looking at
+
+263
+00:17:43,400 --> 00:17:46,060
+the quality and the quantity as well we can know
+
+264
+00:17:46,060 --> 00:17:50,680
+if this is commercial or civil so we can know that
+
+265
+00:17:50,680 --> 00:17:53,920
+the intention behind this it's not difficult to
+
+266
+00:17:53,920 --> 00:17:58,760
+know it in addition there's one point left here in
+
+267
+00:17:58,760 --> 00:18:03,560
+this slide it's in if we cannot invalidate if we
+
+268
+00:18:03,560 --> 00:18:07,110
+cannot invalidate يعني ينهيالعقد the contract if
+
+269
+00:18:07,110 --> 00:18:09,730
+we cannot invalidate it because we have no
+
+270
+00:18:09,730 --> 00:18:13,310
+intention then we can look at something else like
+
+271
+00:18:13,310 --> 00:18:17,050
+someone bought my car at the time when I was drunk
+
+272
+00:18:17,050 --> 00:18:19,750
+he bought it for less than for less than the
+
+273
+00:18:19,750 --> 00:18:24,550
+amount of the money in I could not approve I could
+
+274
+00:18:24,550 --> 00:18:27,110
+not approve to the court that I had no intention
+
+275
+00:18:27,110 --> 00:18:29,750
+then I can sue that person for something else
+
+276
+00:18:29,750 --> 00:18:34,790
+which is called unjust enrichment law في قانون
+
+277
+00:18:39,350 --> 00:18:44,990
+الارتناع بغير سبب مشروع، he has my car for five
+
+278
+00:18:44,990 --> 00:18:47,690
+thousand pounds and it cost twenty thousand
+
+279
+00:18:47,690 --> 00:18:55,190
+pounds, it is not illogicalهو ليس شخص ما يمكنه أن
+
+280
+00:18:55,190 --> 00:18:58,490
+يؤمن بذلك إذا كنت أستطيع أن أثبت أن لدينا شيء يسمى
+
+281
+00:18:58,490 --> 00:19:03,010
+فرصة تحفية غير صحيحة لو شخص ما يحصل على مال على
+
+282
+00:19:03,010 --> 00:19:06,130
+مستخدم أو لو شخص ما يحصل على مستخدم على مستخدم من
+
+283
+00:19:06,130 --> 00:19:11,540
+شخص آخر فأنا أستطيع أن أستخدم هذه الفرصة لإعادةأو
+
+284
+00:19:11,540 --> 00:19:14,560
+على الأقل أستطيع أن أحصل على الفرصة إذا كان
+
+285
+00:19:14,560 --> 00:19:18,600
+السيارة تكلف 10 ألف وكنت أشتريها ل 2 أو 3 ألف ريال
+
+286
+00:19:18,600 --> 00:19:21,200
+فأنا أستطيع أن أحصل على الفرصة بين المدى المال
+
+287
+00:19:21,200 --> 00:19:27,540
+أعتقد أن هذا ليس صعبًا هل فهمت؟ جيد دعونا نتحرك
+
+288
+00:19:27,540 --> 00:19:35,440
+للصفحة التالفة الآن قمنا بإنهاء كل الواضحينnumber
+
+289
+00:19:35,440 --> 00:19:38,320
+one is offer and acceptance number two is
+
+290
+00:19:38,320 --> 00:19:43,840
+consideration the value and three is intention now
+
+291
+00:19:43,840 --> 00:19:47,180
+we have to move to additional additional condition
+
+292
+00:19:47,180 --> 00:19:51,920
+which can be sometime in someفي بعض الحالات مثلا
+
+293
+00:19:51,920 --> 00:19:55,420
+إذا كنت تريد أن تشتري منزل في أى مكان في أكتر
+
+294
+00:19:55,420 --> 00:19:58,780
+البلد إذا ليس كلها إذا كنت تريد أن تشتري منزل يجب
+
+295
+00:19:58,780 --> 00:20:01,940
+أن تشتري و يجب أن تشتري و تشتري مجلد لا أستطيع ..
+
+296
+00:20:01,940 --> 00:20:06,560
+لا أستطيع أن أحصل على إسم المنزل من المنزل إلا إذا
+
+297
+00:20:06,560 --> 00:20:12,180
+كان لديه شكل خاص لدينا كما ترى هذا شكل خاص
+
+298
+00:20:20,310 --> 00:20:25,210
+في أغلب الحالات في أغلب الحالات لا يجب أن تكتب كل
+
+299
+00:20:25,210 --> 00:20:31,590
+ما يمكنك فعله في أغلب الحالاتjust to have exchange
+
+300
+00:20:31,590 --> 00:20:35,110
+of promises I promise to sell you something and
+
+301
+00:20:35,110 --> 00:20:37,990
+you promise to buy it and I make an offer and you
+
+302
+00:20:37,990 --> 00:20:41,770
+make an acceptance these are in most cases can be
+
+303
+00:20:41,770 --> 00:20:46,330
+oral can be by conduct by impression but in some
+
+304
+00:20:46,330 --> 00:20:50,090
+cases here we have them in writing as we will see
+
+305
+00:20:50,090 --> 00:20:52,410
+in the next slide let's have a look first of all
+
+306
+00:20:52,410 --> 00:20:58,750
+at the difference between oral or verbal and non
+
+307
+00:20:58,750 --> 00:21:03,680
+-verbal contractsbecause if it's verbal or non
+
+308
+00:21:03,680 --> 00:21:06,900
+-verbal are the same, we have the same case, we
+
+309
+00:21:06,900 --> 00:21:10,680
+have the same obligations verbal contracts can you
+
+310
+00:21:10,680 --> 00:21:14,820
+read it any contract that uses words spoken or
+
+311
+00:21:14,820 --> 00:21:18,340
+written any okay any contracts using words
+
+312
+00:21:18,340 --> 00:21:25,020
+sentences lettersthese these contracts we call
+
+313
+00:21:25,020 --> 00:21:28,500
+them verbal it can be oral it can be in writing it
+
+314
+00:21:28,500 --> 00:21:31,440
+doesn't make any difference as long as we use not
+
+315
+00:21:31,440 --> 00:21:35,580
+conduct we use words then this is a verbal verb
+
+316
+00:21:35,580 --> 00:21:40,360
+from verb فعل verbal contracts and so it means all
+
+317
+00:21:40,360 --> 00:21:44,700
+oral contracts and written contracts the second
+
+318
+00:21:44,700 --> 00:21:52,800
+type isnon-verbal a contract implied by the act of
+
+319
+00:21:52,800 --> 00:21:55,540
+the parties which can be either implied itself or
+
+320
+00:21:55,540 --> 00:22:01,180
+non-verbal most
+
+321
+00:22:01,180 --> 00:22:08,680
+jurisdictions have rules which mean they are non
+
+322
+00:22:08,680 --> 00:22:13,120
+-verbal or enforceable
+
+323
+00:22:13,380 --> 00:22:19,380
+especially regarding contracting involving large
+
+324
+00:22:19,380 --> 00:22:23,640
+amounts of money or real estate okay now non
+
+325
+00:22:23,640 --> 00:22:28,300
+verbal non oral we do not use verbs no words we
+
+326
+00:22:28,300 --> 00:22:31,730
+use conductwe use conduct we call it implied
+
+327
+00:22:31,730 --> 00:22:35,270
+implied contracts and we had the we had that last
+
+328
+00:22:35,270 --> 00:22:38,350
+time we had the two types one of them is called
+
+329
+00:22:38,350 --> 00:22:40,850
+implied in fact and the second is implied in law
+
+330
+00:22:40,850 --> 00:22:44,110
+so i want someone to explain to me again what we
+
+331
+00:22:44,110 --> 00:22:47,390
+had last time implied in fact and implied in law i
+
+332
+00:22:47,390 --> 00:22:50,150
+think implied in fact is easy just to define it
+
+333
+00:22:50,150 --> 00:22:54,250
+how can we define it implied in fact contract how
+
+334
+00:22:54,250 --> 00:23:02,670
+can how can it be definedأي شخص؟ نحن قلنا نستطيع
+
+335
+00:23:02,670 --> 00:23:07,370
+أن نفهم من الموضوع .. أستطيع أن أفهم من المجالات
+
+336
+00:23:07,370 --> 00:23:16,630
+أن هناك اتفاق .. حتى و لو لم يكن مظهر في كلمات مثل
+
+337
+00:23:16,630 --> 00:23:21,480
+.. مثل الذهاب إلى مقهى كافي ..and a cake piece of
+
+338
+00:23:21,480 --> 00:23:24,680
+cake eating and drinking then once you finish you
+
+339
+00:23:24,680 --> 00:23:27,980
+pay the money and you leave that's implied in fact
+
+340
+00:23:27,980 --> 00:23:33,300
+contract the second type which is implied in law
+
+341
+00:23:33,300 --> 00:23:37,600
+how do you know you know it it's a quizzicontract
+
+342
+00:23:37,600 --> 00:23:41,900
+which means the court or the judge would impose an
+
+343
+00:23:41,900 --> 00:23:47,030
+obligation on one of the partiesلتخلص من المخاطر و
+
+344
+00:23:47,030 --> 00:23:50,710
+قمنا بتشرح هذا في التفاصيل و لدينا مثال عن نظام
+
+345
+00:23:50,710 --> 00:23:57,550
+الـ Sprinkler و الـ Plumber أكتر من المجالات كما
+
+346
+00:23:57,550 --> 00:24:03,110
+ترى في أكتر من المجالات السلطات القانونية في كل
+
+347
+00:24:03,110 --> 00:24:07,710
+البلدان العالمية أكتر من المجالات لديها قواعد و
+
+348
+00:24:07,710 --> 00:24:13,970
+أسلوبات تستطيع أن تجعل مقاومة مقاومة مقاومة غير
+
+349
+00:24:13,970 --> 00:24:18,840
+مقاومةانظر إلى هذا مرة أخرى و مرة أخرى لنرى ماذا
+
+350
+00:24:18,840 --> 00:24:22,780
+سنفعله في المقال التالف و ماذا يعني ذلك؟ في أغلب
+
+351
+00:24:22,780 --> 00:24:27,160
+الحكومات، في أغلب البلدين، لديها شرط صحيح صحيح
+
+352
+00:24:27,160 --> 00:24:30,380
+صحيح صحيح صحيح صحيح صحيح صحيح صحيح صحيح صحيح صحيح
+
+353
+00:24:30,380 --> 00:24:32,860
+صحيح صحيح صحيح صحيح صحيح صحيح صحيح صحيح صحيح صحيح
+
+354
+00:24:32,860 --> 00:24:35,540
+صحيح صحيح صحيح صحيح صحيح صحيح صحيح صحيح صحيح صحيح
+
+355
+00:24:35,540 --> 00:24:42,000
+صحيح صحيح صحيح صحيح صحيح صحيح صحيح
+
+356
+00:24:45,830 --> 00:24:50,750
+و لا نستطيع أن نقوم بإعادته، خاصة إذا كانت هيرغاني
+
+357
+00:24:50,750 --> 00:24:55,710
+تحتوي على عموم كبيرأو عصر حقيقي اذا كان شيء كثير
+
+358
+00:24:55,710 --> 00:25:02,690
+أسعى او عصر حقيقي لو أقرأت شقة او بقعة او بقعة او
+
+359
+00:25:02,690 --> 00:25:03,090
+بقعة او بقعة او بقعة او بقعة او بقعة او بقعة او
+
+360
+00:25:03,090 --> 00:25:04,090
+بقعة او بقعة او بقعة او بقعة او بقعة او بقعة او
+
+361
+00:25:04,090 --> 00:25:05,570
+بقعة او بقعة او بقعة او بقعة او بقعة او بقعة او
+
+362
+00:25:05,570 --> 00:25:05,670
+بقعة او بقعة او بقعة او بقعة او بقعة او بقعة او
+
+363
+00:25:05,670 --> 00:25:05,850
+بقعة او بقعة او بقعة او بقعة او بقعة او بقعة او
+
+364
+00:25:05,850 --> 00:25:08,690
+بقعة او بقعة او بقعة او بقعة او بقعة او ب
+
+365
+00:25:21,670 --> 00:25:27,570
+إلا إذا كان لدينا مقاومة خاصة في كتابة، لذلك يجب
+
+366
+00:25:27,570 --> 00:25:36,590
+أن تكون المقاومة خاصة في كتابة خاصة في كتابة
+
+367
+00:25:36,590 --> 00:25:36,950
+خاصة في كتابة خاصة في كتابة خاصة في كتابة خاصة في
+
+368
+00:25:36,950 --> 00:25:36,950
+كتابة خاصة في كتابة خاصة في كتابة خاصة في كتابة
+
+369
+00:25:36,950 --> 00:25:37,070
+خاصة في كتابة خاصة في كتابة خاصة في كتابة خاصة في
+
+370
+00:25:37,070 --> 00:25:37,070
+كتابة خاصة في كتابة خاصة في كتابة خاصة في كتابة
+
+371
+00:25:37,070 --> 00:25:37,230
+خاصة في كتابة خاصة في كتابة خاصة في كتابة خاصة في
+
+372
+00:25:37,230 --> 00:25:41,670
+كتابة خاصة في كتابة خاصة في كتابة خاصة في كتابة
+
+373
+00:25:41,670 --> 00:25:45,990
+خاصة فيفي بلسطين هنا في قانون عام و ليس قانون
+
+374
+00:25:45,990 --> 00:25:51,990
+مجتمع و قانون عام يقول ان اي مجلس يجعله 200 دينار
+
+375
+00:25:51,990 --> 00:25:57,250
+اكتر يجب ان يكون في الكتابة اذا كان اقل من 200
+
+376
+00:25:57,250 --> 00:26:01,110
+دينار يمكنك ان تحضر شاهد مستحيل ولكن اذا كان 200
+
+377
+00:26:01,110 --> 00:26:04,930
+دينار اكتر و اذا كنت تريد ان تدعي عنه لا يمكنك أن
+
+378
+00:26:04,930 --> 00:26:09,310
+تذهب للدراسة لا أحد سيستمع لك إلا لو كان لديك اي
+
+379
+00:26:09,310 --> 00:26:15,390
+دراسة في الكتابةأي دكتورة لأن الدكتورة ستجعلها
+
+380
+00:26:15,390 --> 00:26:18,510
+أسهل لأي شخص يؤمن بك و حتى ان تنظر إلى الإسلام
+
+381
+00:26:18,510 --> 00:26:26,590
+أكتر قصة في القرآن هي آية الدين تتكلم عن الادات
+
+382
+00:26:26,590 --> 00:26:30,010
+عليك أن تكتب كل شيء عليك أن تكتب كل شيء عليك أن
+
+383
+00:26:30,010 --> 00:26:32,070
+تكتب كل شيء عليك أن تكتب كل شيء عليك أن تكتب كل
+
+384
+00:26:32,070 --> 00:26:32,710
+شيء عليك أن تكتب كل شيء عليك أن تكتب كل شيء عليك
+
+385
+00:26:32,710 --> 00:26:35,810
+أن تكتب كل شيء عليك أن تكتب كل شيء عليك أن تكتب كل
+
+386
+00:26:35,810 --> 00:26:40,350
+شيءلماذا يجب أن نكتب فيها مقال كثير منهم يمكن أن
+
+387
+00:26:40,350 --> 00:26:44,970
+يكتب فيه مقال خاص و بعضهم يمكن أن تصنع المقال ولكن
+
+388
+00:26:44,970 --> 00:26:47,150
+عليك أن تكتب فيه مقال كثير منهم يمكن أن تكتب فيه
+
+389
+00:26:47,150 --> 00:26:48,770
+مقال كثير منهم يمكن أن تكتب فيه مقال كثير منهم
+
+390
+00:26:48,770 --> 00:26:52,170
+يمكن أن تكتب فيه مقال كثير منهم يمكن
+
+391
+00:26:52,170 --> 00:26:53,090
+أن تكتب فيه مقال كثير منهم يمكن أن تكتب فيه مقال
+
+392
+00:26:53,090 --> 00:26:53,230
+كثير منهم يمكن أن تكتب فيه مقال كثير منهم يمكن أن
+
+393
+00:26:53,230 --> 00:26:57,730
+تكتب فيه مقال كثير منهم يمكن أن تكتب فيه مقال كثير
+
+394
+00:26:57,730 --> 00:27:05,530
+منهم يمكن أن تكتب فيه مقال كثير منهم يمكن أن
+
+395
+00:27:07,040 --> 00:27:12,900
+بالطبع نستطيع الانقاذ ولكن يجب أن نوقف ونقفز ونقفز
+
+396
+00:27:12,900 --> 00:27:18,340
+ونقفز ونقفز ونقفز ونقفز ونقفز ونقفز
+
+397
+00:27:20,150 --> 00:27:23,990
+عندما تتكلم عن منزل أو أرض أو شيء أسعر أو بيع شركة
+
+398
+00:27:23,990 --> 00:27:28,350
+أو بيع شركة يجب أن تثبت كل ما تقوله لكي أعطيه
+
+399
+00:27:28,350 --> 00:27:32,230
+الوثيقة إلا أن الناس ستستمر في إدعاء الأشياء
+
+400
+00:27:32,230 --> 00:27:35,770
+ويقولوا هذا هو سيارتي و هذا هو منزلي إذا كنت أرغب
+
+401
+00:27:35,770 --> 00:27:40,970
+في إدعاء أي شيء يجب أن أثبت أنه يتلقى لي كيف
+
+402
+00:27:40,970 --> 00:27:44,250
+يمكنني أن أثبته في مواقعي؟ وقد رأينا الكثير من
+
+403
+00:27:44,250 --> 00:27:46,670
+الحكومة عندما تذهب إلى الحكومة وترى كم عدد الحكومة
+
+404
+00:27:46,670 --> 00:27:51,220
+التي لدينابعض الملايين من الحلقات عن الأشياء التي
+
+405
+00:27:51,220 --> 00:27:56,480
+كانت مقارنة بين الجمهور كل واحد يقول ان هذا يشرفني
+
+406
+00:27:56,480 --> 00:28:01,300
+هذا الأشياء هذا المخزن هذا الشيطان انه يشرفني انه
+
+407
+00:28:01,300 --> 00:28:05,320
+ملين لديه لدينا الكثير من المقارنات فلما نستطيع أن
+
+408
+00:28:05,320 --> 00:28:10,200
+نحصل على مقالات لكي نثبت ممتازة واحدة منهم فهو أو
+
+409
+00:28:10,200 --> 00:28:15,240
+انها ستأخذ القرار سينظر في هذه اللحظة وسياخذ قرار
+
+410
+00:28:16,050 --> 00:28:22,850
+بسيطة على الوثيقة المكتوبة لذلك نمنع أي ادعاء كاذب
+
+411
+00:28:22,850 --> 00:28:27,170
+نمنع اي ادعاء
+
+412
+00:28:27,170 --> 00:28:31,470
+كاذب لا يسمح لنا الناس بعمل اي ادعاء كاذب انا لا
+
+413
+00:28:31,470 --> 00:28:35,450
+اريد اي احد يدفع اي سيارتي لانها سيارتي كمان كمان
+
+414
+00:28:35,450 --> 00:28:40,560
+كمان كمان كمان كمان كمان كمانأنا لدي مقال من مدير
+
+415
+00:28:40,560 --> 00:28:46,040
+التransportation تقول أن هذه السيارة تتلقى لي ،
+
+416
+00:28:46,040 --> 00:28:49,980
+لذلك تحتاج أن تكون لديك مقال خاص لك عندما تشتري
+
+417
+00:28:49,980 --> 00:28:54,440
+سيارة كيبي في مكانك كيبي في مقالك، هذا المقال هو
+
+418
+00:28:54,440 --> 00:28:58,480
+دليلك ولكن إذا كان شيء بسيط مثل هاتف موبايل مثل
+
+419
+00:28:58,480 --> 00:29:01,640
+السيارات ليس شيء مستحيل لا يجب أن تكتبه الأن
+
+420
+00:29:02,560 --> 00:29:04,820
+something expensive have to be written down to
+
+421
+00:29:04,820 --> 00:29:08,700
+prevent any false allegation okay and i just want
+
+422
+00:29:08,700 --> 00:29:10,540
+somebody to read this sentence for me
+
+423
+00:29:10,540 --> 00:29:16,640
+unenforceable
+
+424
+00:29:16,640 --> 00:29:26,260
+restitution
+
+425
+00:29:26,260 --> 00:29:31,700
+that's fine let's say that we have a contractA and
+
+426
+00:29:31,700 --> 00:29:37,240
+B offer an acceptance and we have intention and we
+
+427
+00:29:37,240 --> 00:29:41,380
+have a consideration the money and the item
+
+428
+00:29:41,380 --> 00:29:47,180
+commoditiesولكن هذا التقرير لم يكن في الكتابة ولكن
+
+429
+00:29:47,180 --> 00:29:51,180
+القانون قال ان يجب أن تجعله في الكتابة يجب أن
+
+430
+00:29:51,180 --> 00:29:55,320
+تجعله في كتابة خاصة فهذا التقرير غير قادر على
+
+431
+00:29:55,320 --> 00:29:58,200
+تحميله وهو بخير وهو بخير بطريقة الحكومة انه تقرير
+
+432
+00:29:58,200 --> 00:30:04,920
+ولكنه غير قادر على تحميله مثلا انا لدي سيارة وانا
+
+433
+00:30:04,920 --> 00:30:09,000
+لدي التقرير لكي اثبت ان هذه سيارتي لي وانت لدي
+
+434
+00:30:09,000 --> 00:30:14,690
+المال وانت تريد أن تشتريهأنا قمت بإعطاء اعطاء
+
+435
+00:30:14,690 --> 00:30:17,130
+اعطاء اعطاء اعطاء اعطاء اعطاء اعطاء اعطاء اعطاء
+
+436
+00:30:17,130 --> 00:30:18,290
+اعطاء اعطاء اعطاء اعطاء اعطاء اعطاء اعطاء اعطاء
+
+437
+00:30:18,290 --> 00:30:19,250
+اعطاء اعطاء اعطاء اعطاء اعطاء اعطاء اعطاء اعطاء
+
+438
+00:30:19,250 --> 00:30:22,650
+اعطاء اعطاء اعطاء اعطاء اعطاء اعطاء اعطاء اعطاء
+
+439
+00:30:22,650 --> 00:30:24,030
+اعطاء اعطاء اعطاء اعطاء اعطاء اعطاء اعطاء اعطاء
+
+440
+00:30:24,030 --> 00:30:26,630
+اعطاء اعطاء اعطاء اعطاء اعطاء اعطاء اعطاء اعطاء
+
+441
+00:30:26,630 --> 00:30:30,230
+اعطاء اعطاء
+
+442
+00:30:30,230 --> 00:30:35,170
+اعطاء
+
+443
+00:30:35,170 --> 00:30:43,860
+اعطاء اعيجب أن تكتب اسمك و أشيائك و كل شيء و هذه
+
+444
+00:30:43,860 --> 00:30:51,480
+الصورة ستتم تسجيلها إلى مجلس التransportation الان
+
+445
+00:30:51,480 --> 00:30:56,620
+انت لا يمكنك ان تجعلني أعطيك السيارة التعامل اللي
+
+446
+00:30:56,620 --> 00:31:00,580
+قررناه كان تماما تماما انت تبقى مالك و انا ابقى
+
+447
+00:31:00,580 --> 00:31:03,420
+سيارتي اقبلك السيارة اقبلك السيارة اقبلك السيارة
+
+448
+00:31:03,420 --> 00:31:04,420
+اقبلك السيارة اقبلك السيارة اقبلك السيارة اقبلك
+
+449
+00:31:04,420 --> 00:31:07,400
+السيارة اقبلك السيارة اقبلك السيارة اقبلك السيارة
+
+450
+00:31:07,400 --> 00:31:08,770
+اقبلك السيارة اقبلك السيارة اقبلك السيارةلا أستطيع
+
+451
+00:31:08,770 --> 00:31:12,050
+أن أقوم بأنفسي ولا أستطيع أن أوقف كل شيء لا أحد
+
+452
+00:31:12,050 --> 00:31:15,610
+يستطيع أن يجعلني أقوم بإدارة السيارة لأننا نفقد
+
+453
+00:31:15,610 --> 00:31:23,010
+واحد من الواضحين وهو التصريحات التصريحات هذا
+
+454
+00:31:23,010 --> 00:31:27,730
+التجارب لم يكن في الكتابة لم يكن في شكل خاص فلا
+
+455
+00:31:27,730 --> 00:31:31,130
+أحد يستطيع أن يجعلني اقوم بذلك نفس الشيء عندما
+
+456
+00:31:31,130 --> 00:31:35,970
+تسحب منزل أو قطعة الأرض عندما تسحب شيء أسعارالشركة
+
+457
+00:31:35,970 --> 00:31:38,590
+ستبقى مستعمرة ستكون على ما يرام ستكون على ما يرام
+
+458
+00:31:38,590 --> 00:31:42,270
+ولكن لا يمكنك أن تقوم بإعادةها يعني عقد مية في
+
+459
+00:31:42,270 --> 00:31:45,990
+المية one hundred percent is fine لكن مافيش تطبيق
+
+460
+00:31:45,990 --> 00:31:50,670
+it's not enforceable لا أحد يستطيع أن يجعلني أعطيك
+
+461
+00:31:50,670 --> 00:31:55,910
+سيارتي only one case only in one situation we have
+
+462
+00:31:55,910 --> 00:32:01,060
+exceptional case if we have this conditionثم
+
+463
+00:32:01,060 --> 00:32:05,000
+نستطيع أن نقول إن هذا التجارب يمكن أن يكون قادرًا
+
+464
+00:32:05,000 --> 00:32:08,760
+نستطيع أن نقوم بقضاء كلا الحكومة في هذه الحالة
+
+465
+00:32:08,760 --> 00:32:15,940
+مثلًا هنا واحدة حكومة كانت غير صادقة من خلال تجارب
+
+466
+00:32:15,940 --> 00:32:19,320
+غير قادرة ربما مواجهة تعويض هنا لدينا بعض نوع من
+
+467
+00:32:19,320 --> 00:32:22,680
+التعويض فيه تعويض واحدة حكومة مثلًا انا سألتقى
+
+468
+00:32:22,680 --> 00:32:25,460
+مثلًا انا لدي السيارة وانت لدي المال
+
+469
+00:32:31,880 --> 00:32:37,520
+لأ انا بعيد هيا .. لأ القصة بس بس بس بس بس بس بس
+
+470
+00:32:37,520 --> 00:32:37,520
+بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس
+
+471
+00:32:37,520 --> 00:32:39,060
+بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس
+
+472
+00:32:39,060 --> 00:32:41,780
+بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس
+
+473
+00:32:41,780 --> 00:32:44,360
+بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس
+
+474
+00:32:44,360 --> 00:32:44,600
+بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس
+
+475
+00:32:44,600 --> 00:32:48,400
+بس بس بس بس بس بس بس بس بس بس بس بس
+
+476
+00:32:48,400 --> 00:32:57,540
+بس
+
+477
+00:32:57,870 --> 00:33:01,310
+الشركة كانت ممتعه ولكنك فقط كنت تدعي أنك تريد
+
+478
+00:33:01,310 --> 00:33:06,790
+السيارة و أنا قلت لا لأنني لم أشتر الشركة معك و
+
+479
+00:33:06,790 --> 00:33:09,270
+أنا لن أعطي السيارة و أنا أستمر في استخدام السيارة
+
+480
+00:33:09,270 --> 00:33:12,450
+و المال ثم ما يمكنها أن تفعله هي أن تذهب إلى الحجر
+
+481
+00:33:12,450 --> 00:33:16,950
+و تستطيع أن تدعي السيارة لأنني هنا في هذه الحالة
+
+482
+00:33:17,540 --> 00:33:23,360
+واحدة شركة غير محققه اغتنيت انا استخدم المال انا
+
+483
+00:33:23,360 --> 00:33:25,980
+استخدم السيارة وانها لا تستخدم اي شيء ليس فقط عن
+
+484
+00:33:25,980 --> 00:33:30,460
+السيارة فهو يمكن ان يكون بعض الوقت تجارب وهذه
+
+485
+00:33:30,460 --> 00:33:33,880
+التجارب يمكن ان تكلف مليارات ربما مئات ألف دولار
+
+486
+00:33:33,880 --> 00:33:37,480
+كبيرة كبيرة كبيرة كبيرة كبيرة كبيرة كبيرة كبيرة
+
+487
+00:33:37,480 --> 00:33:37,480
+كبيرة كبيرة كبيرة كبيرة كبيرة كبيرة كبيرة كبيرة
+
+488
+00:33:37,480 --> 00:33:45,780
+كبيرة كبيرة كبيرة
+
+489
+00:33:45,780 --> 00:33:47,200
+كبيرة كبيرة كبيرة كبيرة كبيرة كبيرة كبيرة كبيرة
+
+490
+00:33:47,200 --> 00:33:47,200
+كبيرة كبيرة كبيرة كبيرة كبيرة كبيرة كبيرة كبيرة
+
+491
+00:33:47,200 --> 00:33:49,520
+كبيرة كبيرة كبيرة كبيرة كبيرة كبيرة كعرفت ان واحد
+
+492
+00:33:49,520 --> 00:33:53,000
+من الناس لديه الأموال و المجتمع و لديه المال و
+
+493
+00:33:53,000 --> 00:33:57,040
+الثانوي لديه لا شيء ثم واحد من الناس لديه المال و
+
+494
+00:33:57,040 --> 00:33:57,460
+المجتمع و لا شيء ثم واحد من الناس لديه المال و
+
+495
+00:33:57,460 --> 00:33:57,940
+المجتمع و لا شيء ثم واحد من الناس لديه المال و
+
+496
+00:33:57,940 --> 00:33:58,460
+المجتمع و لا شيء ثم واحد من الناس لديه المال و
+
+497
+00:33:58,460 --> 00:33:58,580
+المجتمع و لا شيء ثم واحد من الناس لديه المال و
+
+498
+00:33:58,580 --> 00:34:00,140
+المجتمع و لا شيء ثم واحد من الناس لديه المال و
+
+499
+00:34:00,140 --> 00:34:01,220
+المجتمع و لا شيء ثم واحد من الناس لديه المال و
+
+500
+00:34:01,220 --> 00:34:02,340
+المجتمع و لا شيء ثم واحد من الناس لديه المال و
+
+501
+00:34:02,340 --> 00:34:15,200
+المجتمع و لا شيء ثم
+
+502
+00:34:15,200 --> 00:34:24,080
+واحد من الناس لو ماهي الوضع اللي نحتاجه؟ الوضع
+
+503
+00:34:24,080 --> 00:34:29,540
+يمكن أن يكون بعض الوقت قطع قطعة بس بس بس بس بس بس
+
+504
+00:34:29,540 --> 00:34:34,060
+بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس
+
+505
+00:34:34,060 --> 00:34:35,220
+بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس
+
+506
+00:34:35,220 --> 00:34:36,300
+بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس
+
+507
+00:34:36,300 --> 00:34:36,300
+بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس
+
+508
+00:34:36,300 --> 00:34:36,500
+بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس
+
+509
+00:34:36,500 --> 00:34:41,820
+بس بس بس
+
+510
+00:34:41,820 --> 00:34:44,760
+ب
+
+511
+00:34:50,760 --> 00:34:54,320
+في بعض الأحيان يمكننا أن نكتب نصف مقالتنا، يمكن أن
+
+512
+00:34:54,320 --> 00:34:56,760
+يكون على قطعة من الأوراق، لكن الاخر نصف مقالتنا
+
+513
+00:34:56,760 --> 00:35:03,120
+ستكون في الأوراق، خاصة أن لدينا بعض المقالات يمكن
+
+514
+00:35:03,120 --> 00:35:07,260
+أن تكون أكتر من 200 مقالات أو 300 مقالات، المقالات
+
+515
+00:35:07,260 --> 00:35:10,440
+يمكن أن تكون بعض الأحيان نصف مقالة أو 2 مقالات،
+
+516
+00:35:10,440 --> 00:35:15,790
+بعض المقالات بين شركات كبيرةهم لديهم مئات صفحات
+
+517
+00:35:15,790 --> 00:35:19,350
+تتكلم عن تفاصيل صغيرة لدي واحد من حالتين انا رأيت
+
+518
+00:35:19,350 --> 00:35:23,390
+واحد من حالتين في غزا سيتي هنا في الواقع ان مستخدم
+
+519
+00:35:23,390 --> 00:35:29,670
+قام بإشتراك اتفاق مع الامريكية للبناء خمس او أسعار
+
+520
+00:35:29,670 --> 00:35:34,270
+من المنازل حوالي خمس او أسعار من المنازل هذا
+
+521
+00:35:34,270 --> 00:35:39,210
+التفاق كان حوالي خمس أسعة صفحات تتكلم عن التفاصيل
+
+522
+00:35:39,210 --> 00:35:40,930
+عن كل شيء
+
+523
+00:35:44,420 --> 00:35:48,860
+الأشياء و كيف تفعلها و التغيير من المال و
+
+524
+00:35:48,860 --> 00:35:52,400
+المدفوعات في حالة اتفاق عن كيف يفعلوها و كيف
+
+525
+00:35:52,400 --> 00:35:52,900
+يفعلوها و كيف يفعلوها و كيف يفعلوها و كيف يفعلوها
+
+526
+00:35:52,900 --> 00:35:54,320
+و كيف يفعلوها و كيف يفعلوها و كيف يفعلوها و كيف
+
+527
+00:35:54,320 --> 00:35:55,280
+يفعلوها و كيف يفعلوها و كيف يفعلوها و كيف يفعلوها
+
+528
+00:35:55,280 --> 00:35:55,520
+و كيف يفعلوها و كيف يفعلوها و كيف يفعلوها و كيف
+
+529
+00:35:55,520 --> 00:35:55,660
+يفعلوها و كيف يفعلوها و كيف يفعلوها و كيف يفعلوها
+
+530
+00:35:55,660 --> 00:35:55,980
+و كيف يفعلوها و كيف يفعلوها و كيف يفعلوها و كيف
+
+531
+00:35:55,980 --> 00:36:00,080
+يفعلوها و كيف يففي بعض الأحيان لا يجب أن تصنع 500
+
+532
+00:36:00,080 --> 00:36:04,800
+صفر لما يمكنك فعله، يمكنك صنع 100 صفر، 50 صفر، 1
+
+533
+00:36:04,800 --> 00:36:08,340
+صفر يمكن أن يكون التطبيق، ولكن باقية الأمر يمكن أن
+
+534
+00:36:08,340 --> 00:36:11,940
+يكون أورالي، يمكننا أن نفهمه، خاصة في السوق، في
+
+535
+00:36:11,940 --> 00:36:16,560
+السوق، الشركات لديها ثقافة، قلنا ثقافة هي واحدة من
+
+536
+00:36:16,560 --> 00:36:21,510
+أساسيات القواعد التجاربيالثقافة بين الأعضاء و
+
+537
+00:36:21,510 --> 00:36:26,950
+السرعة فلا يجب علينا أن نكتب كل شيء في قطع كتابة
+
+538
+00:36:26,950 --> 00:36:32,750
+أو في مقالة ليس كذلك يمكننا أن نكتب بعض الأشياء
+
+539
+00:36:32,750 --> 00:36:36,430
+بعض الكلمات يمكن أن تكون في الكتابة و بعضها يمكن
+
+540
+00:36:36,430 --> 00:36:41,810
+أن تكون في الكتابة نقل لكتابة كامة في الكتابة في
+
+541
+00:36:41,810 --> 00:36:45,170
+حالات أخرى يمكننا أن نستخدم كتبات أي كتابة تحبها
+
+542
+00:36:45,810 --> 00:36:49,590
+يمكنك فقط تلقى مقالة يمكنك استخدام أي مقالة ولكن
+
+543
+00:36:49,590 --> 00:36:54,230
+هذه المقالة يجب أن تشير إلى أن كلا الشركات قد
+
+544
+00:36:54,230 --> 00:36:58,850
+فعلوا مقالة او هذه المقالة هنا يجب أن تحتوي على
+
+545
+00:36:58,850 --> 00:37:03,410
+التالي رقم واحد يجب أن يكون مقالة اي مقالة تريد ان
+
+546
+00:37:03,410 --> 00:37:08,310
+تجعلها مقالة فقط مقالة من مدير مجلس الاقتصادي او
+
+547
+00:37:08,310 --> 00:37:09,010
+مجلس الاقتصادي او مجلس الاقتصادي او مجلس الاقتصادي
+
+548
+00:37:09,010 --> 00:37:10,070
+او مجلس الاقتصادي او مجلس الاقتصادي او مجلس
+
+549
+00:37:10,070 --> 00:37:14,050
+الاقتصادي او مجلس الاقتصادي او مجلس الاقتصادي او
+
+550
+00:37:14,050 --> 00:37:19,500
+مجلس الاقتصاmaterials terms conditions everything
+
+551
+00:37:19,500 --> 00:37:24,980
+between the two sides and
+
+552
+00:37:24,980 --> 00:37:27,780
+for example in addition to this in England in
+
+553
+00:37:27,780 --> 00:37:33,180
+England sometime they use they use the guarantees
+
+554
+00:37:33,180 --> 00:37:37,620
+when you buy something an item from Sony for
+
+555
+00:37:37,620 --> 00:37:42,630
+example to Shibaلن تكون لديك مقرارات فقط لديك
+
+556
+00:37:42,630 --> 00:37:45,570
+مقرارات و قطعة من البرنامج تقول إن هذا مقرارات و
+
+557
+00:37:45,570 --> 00:37:51,590
+هذا مقرارات أن هذا الهاتف لديه مقرارات لعام واحد
+
+558
+00:37:51,590 --> 00:37:57,070
+أو لعام اثنين هذا يكفي كوارثة و يمكن استخدامها
+
+559
+00:37:57,070 --> 00:38:00,490
+كمقارنة لمقرارات
+
+560
+00:38:05,180 --> 00:38:09,900
+عند إشتراك التطبيق عند إشتراكه يعني أنك قبلت كل
+
+561
+00:38:09,900 --> 00:38:13,740
+شيء حتى لو لم تكن تقرأ
+
+562
+00:38:16,650 --> 00:38:20,810
+هذا ببساطة يعني انك تفهم ماذا لديك في هذا التجارب
+
+563
+00:38:20,810 --> 00:38:24,450
+و أنت تقبله حتى لو لم تنظر لهو و انا أعرف ان
+
+564
+00:38:24,450 --> 00:38:28,910
+الكثير من الناس لا ينظر إلى المحتوى كثير منهم عامة
+
+565
+00:38:28,910 --> 00:38:31,810
+عندما تشتري شيء على الإنترنت عندما تشتري شيء على
+
+566
+00:38:31,810 --> 00:38:35,870
+الإنترنت اقبله حتى تقبله حتى تقبله حتى تقبله حتى
+
+567
+00:38:35,870 --> 00:38:44,590
+تقبله حتى تقبله حتى تقبله حتى تقبله حتى تقبله حتى
+
+568
+00:38:44,590 --> 00:38:45,230
+تقبله حتى تقبله حتى تقبله حتى تقبله حتى تقبله حتى
+
+569
+00:38:45,230 --> 00:38:45,490
+تقبله حتى تقبله حتى تقبله حتى تقبله حتى تقبله حتى
+
+570
+00:38:45,490 --> 00:38:52,610
+تقبله حتى تقبلبعد ذلك يعني انك فهمت وقبلت كل شيء
+
+571
+00:38:52,610 --> 00:39:02,670
+فهمت؟ فهمت ما اقوله؟ نعم فهمت بإضافة
+
+572
+00:39:02,670 --> 00:39:05,990
+انك تستطيع استخدام اي مقال اي مقال يمكن استخدامه
+
+573
+00:39:05,990 --> 00:39:10,650
+كمعالجة لتحديد التجارب يتعامل مع كلا الجانبين اذا
+
+574
+00:39:10,650 --> 00:39:16,550
+كلا الجانبين قبلت مقال او كتابةأو قطعة أوراق أو
+
+575
+00:39:16,550 --> 00:39:18,290
+قطعة أوراق أو قطعة أوراق أو قطعة أوراق أو قطعة
+
+576
+00:39:18,290 --> 00:39:22,230
+أوراق أو قطعة أوراق أو قطعة أوراق أو قطعة أوراق أو
+
+577
+00:39:22,230 --> 00:39:26,910
+قطعة أوراق أو قطعة أوراق أو قطعة أوراق أو قطعة
+
+578
+00:39:26,910 --> 00:39:28,970
+أوراق أو قطعة أوراق أو قطعة أوراق أو قطعة أوراق أو
+
+579
+00:39:28,970 --> 00:39:30,070
+قطعة أوراق أو قطعة أوراق أو قطعة أوراق أو قطعة
+
+580
+00:39:30,070 --> 00:39:30,690
+أوراق أو قطعة أوراق أو قطعة أوراق أو قطعة أوراق أو
+
+581
+00:39:30,690 --> 00:39:33,110
+قطعة أوراق أو قطعة أوراق أو قطعة أوراق أو قطعة
+
+582
+00:39:33,110 --> 00:39:38,200
+أوراق أو قطعة أوراق أو قطعة أوراهو لا يوجد باركين
+
+583
+00:39:38,200 --> 00:39:42,460
+لوتز بارك السيارات بارك السيارات بارك السيارة بارك
+
+584
+00:39:42,460 --> 00:39:47,640
+السيارة بارك السيارة بارك السيارة بارك السيارة
+
+585
+00:39:47,640 --> 00:39:48,260
+بارك السيارة بارك السيارة بارك السيارة بارك
+
+586
+00:39:48,260 --> 00:39:48,280
+السيارة بارك السيارة بارك السيارة بارك السيارة
+
+587
+00:39:48,280 --> 00:39:48,380
+بارك السيارة بارك السيارة بارك السيارة بارك
+
+588
+00:39:48,380 --> 00:39:48,380
+السيارة بارك السيارة بارك السيارة بارك السيارة
+
+589
+00:39:48,380 --> 00:39:48,740
+بارك السيارة بارك السيارة بارك السيارة بارك
+
+590
+00:39:48,740 --> 00:39:52,080
+السيارة بارك السيارة بارك السيارة بارك السيارة
+
+591
+00:39:52,080 --> 00:39:58,320
+بارك السيارة
+
+592
+00:39:58,320 --> 00:40:02,680
+بارك السيارة
+
+593
+00:40:02,680 --> 00:40:07,840
+بهذا يعني أنك قمت بإشارة شركة أو إشارة شركة مع
+
+594
+00:40:07,840 --> 00:40:14,240
+شركة و الشركة تعمل على حسب شركة
+
+595
+00:40:14,240 --> 00:40:19,700
+شركة و الشركة تعمل على حسب شركة و الشركة تعمل على
+
+596
+00:40:19,700 --> 00:40:19,960
+حسب شركة و الشركة تعمل على حسب شركة و شركة تعمل
+
+597
+00:40:19,960 --> 00:40:19,980
+على حسب شركة و شركة تعمل على حسب شركة و شركة تعمل
+
+598
+00:40:19,980 --> 00:40:19,980
+على حسب شركة تعمل على حسب شركة تعمل على حسب شركة
+
+599
+00:40:19,980 --> 00:40:19,980
+تعمل على حسب شركة تعمل على حسب شركة تعمل على حسب
+
+600
+00:40:19,980 --> 00:40:20,140
+شركة تعمل على حسب شركة تعمل على حسب شركة تعمل على
+
+601
+00:40:20,140 --> 00:40:22,500
+حسب شركة تعمل على حسب شركة تعمل على حسب شركة تعمل
+
+602
+00:40:22,500 --> 00:40:27,960
+على حسب شركة تعمأو مجلد مجلد مجلد مجلد مجلد مجلد
+
+603
+00:40:27,960 --> 00:40:27,980
+مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد
+
+604
+00:40:27,980 --> 00:40:34,380
+مجلد مجلد مجلد مجلد مجلد
+
+605
+00:40:34,380 --> 00:40:37,040
+مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد
+
+606
+00:40:37,040 --> 00:40:38,540
+مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد
+
+607
+00:40:38,540 --> 00:40:38,540
+مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد مجلد
+
+608
+00:40:38,540 --> 00:40:43,020
+مجلد مجلد مجلد
+
+609
+00:40:43,020 --> 00:40:51,720
+مجلد مج
+
+610
+00:40:52,480 --> 00:40:59,860
+والرجل كان يعمل لقرية 20 سنة في مركز سيارة وكان
+
+611
+00:40:59,860 --> 00:41:04,940
+هذا المركز مجتمع مجتمع مجتمع مجتمع مجتمع وكان يحصل
+
+612
+00:41:04,940 --> 00:41:11,740
+على المال كل يوم و بعد 20 سنة فهو فات منه ومدير
+
+613
+00:41:11,740 --> 00:41:17,140
+المركز كان وكان لا يستطيع أن يجد الرجل اللي يعمل
+
+614
+00:41:17,140 --> 00:41:21,130
+في المركز السيارةثم ذهب الى مجلس مجلس مجلس مجلس
+
+615
+00:41:21,130 --> 00:41:21,970
+مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس
+
+616
+00:41:21,970 --> 00:41:24,650
+مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس
+
+617
+00:41:24,650 --> 00:41:25,530
+مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس
+
+618
+00:41:25,530 --> 00:41:28,970
+مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس
+
+619
+00:41:28,970 --> 00:41:30,470
+مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس
+
+620
+00:41:30,470 --> 00:41:35,470
+م
+
+621
+00:41:36,640 --> 00:41:40,260
+في عامين و كان يجمع المال و تعرف كم يمكن أن يكون
+
+622
+00:41:40,260 --> 00:41:43,260
+في بعض الأحيان لتجمع المال في مركز السيارات و ليس
+
+623
+00:41:43,260 --> 00:41:46,380
+حوار .. ليس حوار واحد أو عشر أحياناً يمكن أن يكون
+
+624
+00:41:46,380 --> 00:41:50,500
+مئات السيارات و إذا أخذت من كل سيارة خمسة أسوأ من
+
+625
+00:41:50,500 --> 00:41:52,360
+السيارة السيارة السيارة السيارة السيارة السيارة
+
+626
+00:41:52,360 --> 00:41:52,600
+السيارة السيارة السيارة السيارة السيارة السيارة
+
+627
+00:41:52,600 --> 00:41:52,880
+السيارة السيارة السيارة السيارة السيارة السيارة
+
+628
+00:41:52,880 --> 00:41:54,820
+السيارة السيارة السيارة السيارة السيارة السيارة
+
+629
+00:41:54,820 --> 00:41:59,920
+السيارة
+
+630
+00:41:59,920 --> 00:42:05,340
+السيارة السيارة السيارة السيارة السيارة السيار
+
+631
+00:42:10,010 --> 00:42:13,950
+جيد yes you cannot make it yourself it's not easy
+
+632
+00:42:13,950 --> 00:42:16,750
+come on it just happened sometimes to some people
+
+633
+00:42:16,750 --> 00:42:23,910
+but this is illegal now we have to be legal yeah
+
+634
+00:42:23,910 --> 00:42:27,650
+so many people do illegal ways to get money to be
+
+635
+00:42:27,650 --> 00:42:32,230
+famous and they do everything was made illegally
+
+636
+00:42:32,230 --> 00:42:35,170
+but they will not be protected by law if they are
+
+637
+00:42:35,170 --> 00:42:40,850
+caughtهو سيكون في حجة و هو سيخسر كل شيء هناك شيء
+
+638
+00:42:40,850 --> 00:42:47,530
+يسمى غير متأكد و غير متأكد غير متأكد و غير متأكد و
+
+639
+00:42:47,530 --> 00:42:48,090
+غير متأكد
+
+640
+00:43:04,610 --> 00:43:11,090
+إذا كانت هذه المعاملة هنا لديك ترمز في كل معاملة
+
+641
+00:43:11,090 --> 00:43:17,850
+لديك ترمز ترمز 1,2,3,4,5 دعونا نلقي نظرة عشان عشان
+
+642
+00:43:17,850 --> 00:43:18,790
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+643
+00:43:18,790 --> 00:43:20,930
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+644
+00:43:20,930 --> 00:43:22,310
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+645
+00:43:22,310 --> 00:43:22,370
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+646
+00:43:22,370 --> 00:43:22,370
+عشان عشان عشان عشان عشان عشان عشان عشان عشان عشان
+
+647
+00:43:22,370 --> 00:43:33,070
+عشان عشان عشان عشان عشان
+
+648
+00:43:33,070 --> 00:43:38,220
+عthis is the contract terms can be title the names
+
+649
+00:43:38,220 --> 00:43:43,060
+name title
+
+650
+00:43:43,060 --> 00:43:46,520
+location
+
+651
+00:43:46,520 --> 00:43:52,220
+price
+
+652
+00:43:52,220 --> 00:43:58,360
+quality and
+
+653
+00:43:58,360 --> 00:44:00,900
+so on and so forth you can have many many items
+
+654
+00:44:00,900 --> 00:44:04,480
+and each one is called termSo these are
+
+655
+00:44:04,480 --> 00:44:08,140
+contractual terms you can add to this sometimes
+
+656
+00:44:08,140 --> 00:44:11,280
+you can have thousands of terms sometimes you can
+
+657
+00:44:11,280 --> 00:44:15,780
+have a few little number small number of terms now
+
+658
+00:44:15,780 --> 00:44:21,400
+contractual terms can be defined as as well any
+
+659
+00:44:21,400 --> 00:44:25,100
+provision forming part of the contract this any
+
+660
+00:44:25,100 --> 00:44:28,440
+provision forming part of the contract is called
+
+661
+00:44:28,440 --> 00:44:31,980
+contractual term some of them are stated in the
+
+662
+00:44:31,980 --> 00:44:36,120
+contractsome of them are stated expressly as you
+
+663
+00:44:36,120 --> 00:44:39,360
+can see that and some of them are implicitly are
+
+664
+00:44:39,360 --> 00:44:41,720
+in the contract they are not stated they are not
+
+665
+00:44:41,720 --> 00:44:45,160
+mentioned but you can understand they are there in
+
+666
+00:44:45,160 --> 00:44:50,480
+the contract so you have expressed and implied
+
+667
+00:44:50,480 --> 00:44:57,190
+terms some of the terms can be legal or lessالقليل
+
+668
+00:44:57,190 --> 00:44:58,970
+من القوية القوية القوية القوية القوية القوية
+
+669
+00:44:58,970 --> 00:45:02,090
+القوية القوية قوية
+
+670
+00:45:02,090 --> 00:45:04,090
+قوية قوية قوية قوية قوية قوية قوية قوية قوية قوية
+
+671
+00:45:04,090 --> 00:45:04,170
+قوية قوية قوية قوية قوية قوية قوية قوية قوية قوية
+
+672
+00:45:04,170 --> 00:45:10,210
+قوية قوية قوية قوية قوية قوية قوية قوية قوية قوية
+
+673
+00:45:10,210 --> 00:45:11,290
+قوية
+
+674
+00:45:28,100 --> 00:45:35,040
+يجب ان اعود الان لصفة 16 كما ترى ان كل هذه الاسمين
+
+675
+00:45:35,040 --> 00:45:42,220
+يجب ان يكونوا صحيحين اسم اسم قيمة جودة موقع أي شيء
+
+676
+00:45:42,220 --> 00:45:46,420
+الوقت كل شيء يجب ان يكون مصطلح في التطبيقات ليس كل
+
+677
+00:45:46,420 --> 00:45:49,720
+شيء لكن التطبيقات ستضمن كل شيء ولكن هذه الاسمين
+
+678
+00:45:49,720 --> 00:45:54,090
+يمكن ان تكونthese are stated here explicit some of
+
+679
+00:45:54,090 --> 00:45:57,150
+them can be implicit we have some cases in which
+
+680
+00:45:57,150 --> 00:46:01,270
+we have uncertainty uncertainty some of the terms
+
+681
+00:46:01,270 --> 00:46:05,970
+were not certain like the quality was not certain
+
+682
+00:46:05,970 --> 00:46:08,830
+what can we do we are not sure what kind of
+
+683
+00:46:08,830 --> 00:46:12,730
+equality do we have do we need what kind of
+
+684
+00:46:12,730 --> 00:46:16,510
+equality do we need it was not clear we have to
+
+685
+00:46:16,510 --> 00:46:23,570
+explain that termI have to translate the words, we
+
+686
+00:46:23,570 --> 00:46:25,830
+have to look at it again and again in order to
+
+687
+00:46:25,830 --> 00:46:29,710
+find a way in which both of us can understand this
+
+688
+00:46:29,710 --> 00:46:33,780
+statement because it was not certain مش واضحit's
+
+689
+00:46:33,780 --> 00:46:36,220
+not sure about it and sometimes some of these
+
+690
+00:46:36,220 --> 00:46:40,440
+terms can be incomplete incomplete it's not
+
+691
+00:46:40,440 --> 00:46:43,320
+complete we have a shortage we mentioned something
+
+692
+00:46:43,320 --> 00:46:45,960
+in the contract but we found out later on that
+
+693
+00:46:45,960 --> 00:46:51,480
+this term was not was not complete in these cases
+
+694
+00:46:51,480 --> 00:46:57,310
+what shall we doلدينا مقالات بين A وB وكانت مقالة
+
+695
+00:46:57,310 --> 00:47:02,190
+تكلف 2 مليون باونز 2 مليون باونز كثير من المال لكن
+
+696
+00:47:02,190 --> 00:47:08,390
+بعدها اكتشفت ان بعض الأشياء بعض التقالات لم تكتمل
+
+697
+00:47:08,390 --> 00:47:13,490
+لم تكون متأكدة ماذا يمكن ان افعل مثلا اشتريت مخزن
+
+698
+00:47:13,490 --> 00:47:22,810
+من 2000 LCD's كثير من المال وعندما كان لدي مقالة
+
+699
+00:47:24,090 --> 00:47:34,730
+كان مقرر بيني ومالك ومالك ومالك ومالك ومالك ومالك
+
+700
+00:47:34,730 --> 00:47:36,930
+ومالك ومالك ومالك ومالك ومالك ومالك ومالك ومالك
+
+701
+00:47:36,930 --> 00:47:36,970
+ومالك ومالك ومالك ومالك ومالك ومالك ومالك ومالك
+
+702
+00:47:36,970 --> 00:47:38,330
+ومالك ومالك ومالك ومالك ومالك ومالك ومالك ومالك
+
+703
+00:47:38,330 --> 00:47:38,550
+ومالك ومالك ومالك ومالك ومالك ومالك ومالك ومالك
+
+704
+00:47:38,550 --> 00:47:38,970
+ومالك ومالك ومالك ومالك ومالك ومالك ومالك ومالك
+
+705
+00:47:38,970 --> 00:47:52,210
+ومالك ومالك ومالك ومالك ومالك ومالك ومالك ومالك و
+
+706
+00:48:00,830 --> 00:48:04,970
+يعني anyone else
+
+707
+00:48:04,970 --> 00:48:07,870
+what do you think if it was you what can you do
+
+708
+00:48:07,870 --> 00:48:12,390
+will you cancel the whole contract will you
+
+709
+00:48:12,390 --> 00:48:16,590
+explain that point are you gonna go to court
+
+710
+00:48:16,590 --> 00:48:20,730
+straight awayلأ ماذا هي المرحلة الأولى اللي
+
+711
+00:48:20,730 --> 00:48:24,750
+ستاخدها أنت لديك مقال بين اتين منك اتين لكن هذا
+
+712
+00:48:24,750 --> 00:48:28,850
+المقال لم يكن واضح هناك شيء يجب أن يكون اكتشف و
+
+713
+00:48:28,850 --> 00:48:31,170
+اشرحه ماذا يجب أن افعل هل يمكنني أن اتصال
+
+714
+00:48:31,170 --> 00:48:37,730
+بالدكتورة؟ لا اتصال بشخص أخر لم يسأله عن حالته
+
+715
+00:48:37,730 --> 00:48:43,190
+وماذا يحتوي عليه و اشرحه ولكنه لم يكن واضح منهم
+
+716
+00:48:43,190 --> 00:48:49,660
+اتصال بشخص أول حاجة هناboth parties a and b have
+
+717
+00:48:49,660 --> 00:48:53,920
+to accept or have to make their attempt to explain
+
+718
+00:48:53,920 --> 00:48:57,400
+that condition if it's a condition it has to be
+
+719
+00:48:57,400 --> 00:49:00,740
+explained if it's a term it has to be identified
+
+720
+00:49:00,740 --> 00:49:04,420
+we have to look how can we understand it we may
+
+721
+00:49:04,420 --> 00:49:07,760
+understand it later on we can complete it if it's
+
+722
+00:49:07,760 --> 00:49:11,760
+not complete the term like for example the title
+
+723
+00:49:11,760 --> 00:49:15,820
+there was a mistake and it was not complete we can
+
+724
+00:49:15,820 --> 00:49:22,770
+complete itربما الموقع لم يكن واضح في مدينة غزا في
+
+725
+00:49:22,770 --> 00:49:26,830
+مدينة نبلس أين بالضبط؟ لم يكن واضح، يمكننا أن نقول
+
+726
+00:49:26,830 --> 00:49:30,630
+إنه في بلستان، لكن أين بالضبط في بلستان؟ يجب أن
+
+727
+00:49:30,630 --> 00:49:35,050
+نكمل في مدينة غزا وينيونس، في مكان آخر، يجب أن
+
+728
+00:49:35,050 --> 00:49:40,310
+نكمل الفرصة إذا كلا الحكومات قبل ذلك النقطة لاحقا،
+
+729
+00:49:40,310 --> 00:49:43,450
+فهي ممتازة، فلا مشكلة
+
+730
+00:49:45,340 --> 00:49:48,920
+الproblem is if we have a dispute both parties
+
+731
+00:49:48,920 --> 00:49:52,760
+could not reach an agreement they could not what
+
+732
+00:49:52,760 --> 00:49:57,420
+can we do a and b both of them insisted that I'm
+
+733
+00:49:57,420 --> 00:50:00,780
+the right person and the second party said well
+
+734
+00:50:00,780 --> 00:50:04,900
+I'm the right one what can I do we have to find a
+
+735
+00:50:04,900 --> 00:50:09,820
+solution we can go to court and the court will
+
+736
+00:50:09,820 --> 00:50:14,300
+attempt to do the same thingسوف نحاول هنا أن نعطي
+
+737
+00:50:14,300 --> 00:50:19,540
+إفاق لشركات شركات مجتمعية ليس أن نتخلص منها لماذا
+
+738
+00:50:19,540 --> 00:50:22,300
+يجب أن نتخلص من الشركة إذا كانت تكلف المال و هذا
+
+739
+00:50:22,300 --> 00:50:26,580
+ما .. هذا قد يؤثر على السوق و سنبقى فقط نحافظ على
+
+740
+00:50:26,580 --> 00:50:33,800
+هذا الشركة و نحافظ علىها و نحاول أن نجعلها مفيدة
+
+741
+00:50:33,800 --> 00:50:36,800
+كفاية ما نستطيع فإذا كان هناك مجلس في الحكومة
+
+742
+00:50:36,800 --> 00:50:40,920
+سأحضر كلا الشركات و أتفاق معهم حتى نجد حلول
+
+743
+00:50:40,920 --> 00:50:49,190
+لشركتهمالقادة ستبحث عن أساسات خارجية مثلًا إذا لم
+
+744
+00:50:49,190 --> 00:50:53,170
+يكن السعر مرتفع سنبحث
+
+745
+00:50:53,170 --> 00:51:00,070
+في السوق على أشياء مشابهة مع نفس القوية ومع نفس
+
+746
+00:51:00,070 --> 00:51:06,920
+المصممات وسنبحث عن أشياء كم تكلفتها في السوقثم
+
+747
+00:51:06,920 --> 00:51:10,160
+يأخذ القرار قرار يعتمد على ذلك ، يعتمد على القواعد
+
+748
+00:51:10,160 --> 00:51:15,200
+الخارجية ويستخدم تصريحه الخاص بيه باستخدام قوة
+
+749
+00:51:15,200 --> 00:51:21,420
+واقوة وانجاستيس القرار هنا سينظر إلى كل حالة وهذا
+
+750
+00:51:21,420 --> 00:51:25,980
+هو المثال هنا ، قانوني يقومون بإستخدام قيمة حسنة ،
+
+751
+00:51:25,980 --> 00:51:31,140
+كلا الشركات قمتوا بإشتراك التجارة ولكنهم لم يتفقوا
+
+752
+00:51:31,140 --> 00:51:37,050
+بالقيمةولم يكن واضح .. كان هناك مقارنة .. هذا
+
+753
+00:51:37,050 --> 00:51:40,250
+النقطة كانت غير مفهومة .. ثم يمكن الحرس أن ينظر
+
+754
+00:51:40,250 --> 00:51:44,710
+إلى مستوى المعاملة وينظر إلى قيمة مفهومة .. الحد
+
+755
+00:51:44,710 --> 00:51:49,770
+المتوسط يعنى .. عامة .. كمية تكلفها في السوق ..
+
+756
+00:51:49,770 --> 00:51:54,070
+إلا إذا كانت شيء مميز .. إذا كانت شيء مميز .. لا
+
+757
+00:51:54,070 --> 00:51:57,130
+يمكننا أن ناخد قرار بسهولة .. مثلًا مثلًا ، أشخاص
+
+758
+00:51:57,130 --> 00:52:00,650
+مستخدين .. لأن أشخاص مستخدين يعتمدون على كمية
+
+759
+00:52:00,650 --> 00:52:06,780
+استخدت ..انها تتعامل مع قيمة وقيمة وقيمة وقيمة
+
+760
+00:52:06,780 --> 00:52:16,140
+وقيمة وقيمة وقيمة وقيمة وقيمة وقيمة وقيمة وقيمة
+
+761
+00:52:17,720 --> 00:52:21,300
+في بعض الأحيان يمكن أن يكون جزء من الأرض يكلف 500
+
+762
+00:52:21,300 --> 00:52:25,120
+دينار في متر و يمكن أن يكون جزء من الأرض المقابل
+
+763
+00:52:25,120 --> 00:52:29,040
+يكلف 200 دينار مقابل بعضها بعضهما واحد سيكون على
+
+764
+00:52:29,040 --> 00:52:32,120
+الطريق الرئيسي والثاني سيكون على الطريق الخارجي
+
+765
+00:52:32,120 --> 00:52:35,720
+وليس نفسه ففي حالة مثل هذه اللحظة يجب أن نكون
+
+766
+00:52:35,720 --> 00:52:39,320
+حذرين و نفعل أفضل من نفسنا سنجد .. سنصل إلى تلك
+
+767
+00:52:39,320 --> 00:52:42,500
+النقطة التي نرى فيها في بعض الأحيان نستطيع أن
+
+768
+00:52:42,500 --> 00:52:43,340
+نتخلص من الوضع
+
+769
+00:52:50,690 --> 00:52:54,010
+look at this each one of them term or clause
+
+770
+00:52:54,010 --> 00:52:58,370
+clause is a term يعني can you read it for anyone
+
+771
+00:52:58,370 --> 00:53:04,730
+of you uncertain or incomplete clauses clauses is
+
+772
+00:53:04,730 --> 00:53:10,050
+a contract plus all option in solving is true
+
+773
+00:53:10,050 --> 00:53:13,070
+meaning perfect okay if we have one of these
+
+774
+00:53:13,070 --> 00:53:18,380
+clauses here sentenceكان غير صحيح .. غير متأكد ..
+
+775
+00:53:18,380 --> 00:53:20,800
+غير مكمل .. و فعلنا أفضل ما فيه .. لم نستطيع أن
+
+776
+00:53:20,800 --> 00:53:23,460
+نقوم بإنهاء الأمر .. نريد أن نقوم بمقابلة .. و لا
+
+777
+00:53:23,460 --> 00:53:24,840
+يمكن الحجر أن يقوم باختيار قرار .. ماذا يمكننا أن
+
+778
+00:53:24,840 --> 00:53:28,920
+نفعل؟ ماذا ستكون الاختيار التالف؟ الاختيار الأول
+
+779
+00:53:28,920 --> 00:53:32,840
+هو أن الانتصارين سيأتيوا مع بعضهم البعض .. يشرحوه
+
+780
+00:53:32,840 --> 00:53:37,540
+.. يحفظوه .. يكملوه .. هم سيذهبوا إلى الحجر .. لا
+
+781
+00:53:37,540 --> 00:53:39,900
+يمكن الحجر أن يقوم باختيار قرار في هذه الحالة ..
+
+782
+00:53:39,900 --> 00:53:41,680
+ثم الاختيار الثالث .. الاختيار الأخير ..
+
+783
+00:53:44,610 --> 00:53:47,970
+هل انت متأكد ؟ هل ستتخلص المعاملة من واحد نقطة
+
+784
+00:53:47,970 --> 00:53:53,810
+فقط؟ من واحد نقطة؟ من واحد كلمة؟ ممتاز، نستطيع أن
+
+785
+00:53:53,810 --> 00:53:58,570
+نتخلص منها نشوف .. نسمع .. نشوف إن كل الاختيارات
+
+786
+00:53:58,570 --> 00:54:04,070
+في حل معنى الحقيقي فشهدت، نستطيع أن نتخلص منها
+
+787
+00:54:04,070 --> 00:54:09,050
+نسمعها عظيمة، عظيمة مغلقة، نستطيع .. نستطيع ..
+
+788
+00:54:09,050 --> 00:54:12,930
+نقطة عظيمة، نستطيع .. نستطيع .. نستطيع .. نستطيع
+
+789
+00:54:12,930 --> 00:54:12,930
+.. نستطيع .. نستطيع .. نستطيع .. نستطيع .. نستطيع
+
+790
+00:54:12,930 --> 00:54:12,930
+.. نستطيع .. نستطيع .. نستطيع .. نستطيع .. نستطيع
+
+791
+00:54:12,930 --> 00:54:17,430
+.. نستطيع .. نستطيع .. نتو مرات اذا دعونا نقول على
+
+792
+00:54:17,430 --> 00:54:24,230
+سبيل المثال قوة .. قوة .. نحن لدينا مشكلة .. نحن
+
+793
+00:54:24,230 --> 00:54:29,490
+لدينا أكتر من القوة و لا يمكننا أن نشرح نوع القوة
+
+794
+00:54:29,490 --> 00:54:33,230
+.. لا يمكننا أن نتفاق عن القوة التي تريدها .. و
+
+795
+00:54:33,230 --> 00:54:38,330
+القوة ليست مواصلة .. هي مواصلة .. عندما تشتري شيء
+
+796
+00:54:38,330 --> 00:54:41,390
+يجب أن تشوف القوة .. هي شيء مهم ..عندما تشتري
+
+797
+00:54:41,390 --> 00:54:45,970
+كمبيوتر تشتري كمبيوتر يجب أن تنظر إلى قيمته إنها
+
+798
+00:54:45,970 --> 00:54:50,090
+مصطلحة و إذا كانت القيمة ليست اللي تريده فيمكنك أن
+
+799
+00:54:50,090 --> 00:54:57,450
+تنخفض كل المعاملة انت ترى أن هذا كان قيمته لدينا
+
+800
+00:54:57,450 --> 00:55:02,650
+كلمة غير مكتملة وهي القيمة انها غير متأكدة و لا
+
+801
+00:55:02,650 --> 00:55:06,930
+يمكننا أن نعرفها بالضبط ما نريده بالضبط هنا في هذه
+
+802
+00:55:06,930 --> 00:55:09,150
+الحالة ما يمكننا أن نفعله هو تنخفضها
+
+803
+00:55:11,260 --> 00:55:15,860
+لنرى إذا قررنا هذا الترميز و باقية الترميز ممكن
+
+804
+00:55:15,860 --> 00:55:20,320
+تبقى فهو بخير المشكلة أن في هذه الحالة فعندما
+
+805
+00:55:20,320 --> 00:55:24,380
+قررنا الترميز الواقعي الترميز نفسه لا يستطيع أن
+
+806
+00:55:24,380 --> 00:55:27,580
+يبقى نحن لا نستطيع أن نبقى نحتاج ترميز الترميز كله
+
+807
+00:55:27,580 --> 00:55:31,320
+إذا قررنا ترميز كثير
+
+808
+00:55:34,950 --> 00:55:41,410
+و إذا كان هناك مصطلح و لا يستطيع أن يبقى بدونه فهو
+
+809
+00:55:41,410 --> 00:55:50,710
+سيغلق كل المصطلح و اذا انا
+
+810
+00:55:50,710 --> 00:55:54,510
+اغلق احد الأشياء و اغلق احد الأشياء اذا انا اغلق
+
+811
+00:55:54,510 --> 00:55:55,830
+احد الأشياء اذا انا اغلق احد الأشياء اذا انا اغلق
+
+812
+00:55:55,830 --> 00:55:56,230
+احد الاشياء اذا انا اغلق احد الاشياء اذا انا اغلق
+
+813
+00:55:56,230 --> 00:55:56,230
+احد الاشياء اذا انا اغلق احد الاشياء اذا انا اغلق
+
+814
+00:55:56,230 --> 00:55:56,230
+احد الاشياء اذا انا اغلق احد الاشياء اذا انا اغلق
+
+815
+00:55:56,230 --> 00:55:58,010
+احد الاشياء اذا انا اغلق احد الاشياء اذا انا اغلق
+
+816
+00:55:58,010 --> 00:56:02,710
+احد الاشياء اذا انا افي بعض الأحيان الموقع يمكن أن
+
+817
+00:56:02,710 --> 00:56:06,610
+يكون مهم جدًا، يجب أن تكون بالضبط في مكانهم،
+
+818
+00:56:06,610 --> 00:56:09,050
+التطبيق يجب أن يتم إعطائه في مكان واحد، في بعض
+
+819
+00:56:09,050 --> 00:56:12,930
+الأحيان الموقع ليس مهم جدًا، مثلًا إعطاء الأموال
+
+820
+00:56:12,930 --> 00:56:17,530
+إلى مكاني في مدينة غزا أو دير البلح، هذا لا يجعل
+
+821
+00:56:17,530 --> 00:56:18,450
+الفرق كبير جدًا.
+
+822
+00:56:21,480 --> 00:56:24,120
+أحيانا احيانا احيانا احيانا احيانا احيانا احيانا
+
+823
+00:56:24,120 --> 00:56:26,000
+احيانا احيانا احيانا احيانا احيانا احيانا احيانا
+
+824
+00:56:26,000 --> 00:56:27,200
+احيانا احيانا احيانا احيانا احيانا احيانا احيانا
+
+825
+00:56:27,200 --> 00:56:29,720
+احيانا احيانا احيانا احيانا احيانا احيانا احيانا
+
+826
+00:56:29,720 --> 00:56:32,840
+احيانا احيانا احيانا احيانا احيانا احيانا احيانا
+
+827
+00:56:32,840 --> 00:56:36,540
+احيانا احيانا احيانا احيانا احيانا احيانا احيانا
+
+828
+00:56:36,540 --> 00:56:40,780
+احيانا احيانا
+
+829
+00:56:40,780 --> 00:56:51,260
+احيان
+
+830
+00:56:51,680 --> 00:56:55,140
+contract is standing without the clause in the eye
+
+831
+00:56:55,140 --> 00:56:58,360
+of a reasonable person this contract can stand
+
+832
+00:56:58,360 --> 00:57:01,620
+without this clause in the eye of a reasonable
+
+833
+00:57:01,620 --> 00:57:05,560
+person so it will be fine it will be legal we can
+
+834
+00:57:05,560 --> 00:57:08,920
+keep it we can keep it and we can just only cancel
+
+835
+00:57:08,920 --> 00:57:14,580
+the location this location here is a term and this
+
+836
+00:57:14,580 --> 00:57:17,800
+term we call it clause a sentence it's called
+
+837
+00:57:17,800 --> 00:57:22,210
+severability clause hereهذا ما يسمى بـ
+
+838
+00:57:22,210 --> 00:57:27,390
+severability clause يعني كلمة يمكن أن تكون محطمة
+
+839
+00:57:27,390 --> 00:57:30,830
+يمكن أن تكون قطعة يمكن أن تكون محطمة يمكن أن تكون
+
+840
+00:57:30,830 --> 00:57:33,490
+محطمة يمكن أن تكون محطمة يمكن أن تكون محطمة يمكن
+
+841
+00:57:33,490 --> 00:57:35,110
+أن تكون محطمة يمكن أن تكون محطمة ممكن أن تكون
+
+842
+00:57:35,110 --> 00:57:35,110
+محطمة ممكن أن تكون محطمة ممكن أن تكون محطمة ممكن
+
+843
+00:57:35,110 --> 00:57:35,410
+أن تكون محطمة ممكن أن تكون محطمة ممكن أن تكون
+
+844
+00:57:35,410 --> 00:57:35,590
+محطمة ممكن أن تكون محطمة ممكن أن تكون محطمة ممكن
+
+845
+00:57:35,590 --> 00:57:37,110
+أن تكون محططة ممكن أن تكون محططة ممكن أن تكون
+
+846
+00:57:37,110 --> 00:57:42,490
+محططة ممكن أن تكون محططة ممكن أن تكون محططة ممكن
+
+847
+00:57:42,490 --> 00:57:45,110
+أن تكون محططة ممكن أن تكون
+
+848
+00:57:58,370 --> 00:58:01,430
+الان بخير لليوم لكن نستطيع أن نسمع طلابها ماذا
+
+849
+00:58:01,430 --> 00:58:09,290
+اسمها؟ حنين أبفول ستقوم بعمل مقدمة لمدة 6-7 دقيقة
+
+850
+00:58:09,290 --> 00:58:12,650
+و لدينا 20 دقيقة
+
diff --git a/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/xLC7lvn2XWA_raw.srt b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/xLC7lvn2XWA_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..50957bd8788c01d3768d06eb9cb58b05e1f21999
--- /dev/null
+++ b/PL9fwy3NUQKwZ6BF_5EuObtvUCYeEvH5PT/xLC7lvn2XWA_raw.srt
@@ -0,0 +1,3268 @@
+1
+00:00:16,220 --> 00:00:20,200
+بسم الله الرحمن الرحيم this is the second chapter
+
+2
+00:00:20,200 --> 00:00:24,060
+we gonna have in commercial law and this is
+
+3
+00:00:24,060 --> 00:00:27,480
+chapter with the title of agency and if you look
+
+4
+00:00:27,480 --> 00:00:32,450
+even in English booksفي القانون العملية ستجد أن
+
+5
+00:00:32,450 --> 00:00:37,410
+الـ agency هو القصة الرئيسية وسنتحدث اليوم عن ال
+
+6
+00:00:37,410 --> 00:00:43,030
+agency كمعنى ومعنى ومفهوم ومفهوم ومفهوم ومفهوم
+
+7
+00:00:43,030 --> 00:00:44,130
+ومفهوم ومفهوم ومفهوم ومفهوم ومفهوم ومفهوم ومفهوم
+
+8
+00:00:44,130 --> 00:00:44,330
+ومفهوم ومفهوم ومفهوم ومفهوم ومفهوم ومفهوم ومفهوم
+
+9
+00:00:44,330 --> 00:00:45,050
+ومفهوم ومفهوم ومفهوم ومفهوم ومفهوم ومفهوم ومفهوم
+
+10
+00:00:45,050 --> 00:00:46,750
+ومفهوم ومفهوم ومفهوم ومفهوم ومفهوم ومفهوم ومفهوم
+
+11
+00:00:46,750 --> 00:00:50,890
+ومفهوم ومفهوم ومفهوم ومفهوم
+
+12
+00:00:50,890 --> 00:00:58,070
+و
+
+13
+00:00:58,300 --> 00:01:01,900
+ستحبها كثيرًا، ليس صعبًا، و أعتقد أننا سنحصل على
+
+14
+00:01:01,900 --> 00:01:06,900
+اتصالات أكتر، و سنحصل على بعض الأمثلة، وسنرى كيف
+
+15
+00:01:06,900 --> 00:01:12,760
+تعمل الحياة في السوق، كيف يعمل الناس، كيف يعمل
+
+16
+00:01:12,760 --> 00:01:18,200
+الشركات، كيف يعمل الأشخاص، كيف يحصلوا على عقدات
+
+17
+00:01:18,200 --> 00:01:21,860
+لعملهم الخاصة، ماهي نوع من المساعدة والمسؤولية
+
+18
+00:01:21,860 --> 00:01:25,880
+التي ستحصل على الرئيس والمشاركة، إذا تنظر إلى هذا
+
+19
+00:01:25,880 --> 00:01:33,270
+الشارت هنا،انظروا ستجدون أننا لدينا هذا النوع ..
+
+20
+00:01:33,270 --> 00:01:38,890
+هذا النوع من العلاقات بين مصطلح و مصطلح و مجتمع
+
+21
+00:01:38,890 --> 00:01:42,330
+ثالث و يجب أن نستخدم هذا المقارنة حتى في المرة
+
+22
+00:01:42,330 --> 00:01:46,510
+القادمة يمكننا أن نقضي وقت طويل في هذه القصة حتى
+
+23
+00:01:46,510 --> 00:01:54,050
+انها ليست قصة طويلة فهي حوالي 22 أسلوب يمكننا أن
+
+24
+00:01:54,050 --> 00:01:57,690
+نكون في اتصالينwe might spend more than that time
+
+25
+00:01:57,690 --> 00:02:00,810
+it depends in on the interaction and the
+
+26
+00:02:00,810 --> 00:02:05,470
+discussion and we see the whole subject here look
+
+27
+00:02:05,470 --> 00:02:08,490
+at this keep in your mind look this this chart
+
+28
+00:02:08,490 --> 00:02:13,990
+keep in your mind private principal الموكل
+
+29
+00:02:13,990 --> 00:02:20,610
+agent الوكيل and third party we call that we call
+
+30
+00:02:20,610 --> 00:02:24,680
+him sometimes the customer the customerI have my
+
+31
+00:02:24,680 --> 00:02:27,720
+own business. I cannot function on my own. I have
+
+32
+00:02:27,720 --> 00:02:31,000
+no time. I want someone else to act on my behalf.
+
+33
+00:02:31,460 --> 00:02:34,240
+That's going to be the agent او كله او select
+
+34
+00:02:34,240 --> 00:02:37,760
+somebody او the trust someone I have confidence
+
+35
+00:02:37,760 --> 00:02:42,020
+in. I would take him or her to be my agent. So
+
+36
+00:02:42,020 --> 00:02:45,320
+that agent would act on behalf of the principal
+
+37
+00:02:45,320 --> 00:02:50,620
+making making many transactions with the customers
+
+38
+00:02:50,620 --> 00:02:54,010
+andفي نهاية اليوم، سيكون الرئيس لديه المساعدة
+
+39
+00:02:54,010 --> 00:02:58,630
+الكامة والخاصة. لذلك، نستطيع أن نرى أن هنا نحن
+
+40
+00:02:58,630 --> 00:03:02,110
+لدينا ثلاثة مجموعات، ثلاثة مجموعات من العلاقات.
+
+41
+00:03:02,170 --> 00:03:08,250
+رقم واحد هو الرئيس للوظيفة، ثم الوظيفة للجمهور
+
+42
+00:03:08,250 --> 00:03:13,630
+الثالث، والأخير الرئيس للجمهور الثالث. ونستطيع أن
+
+43
+00:03:13,630 --> 00:03:17,490
+ندفع هذا حتى نستطيع أن ندفع الوظيفة بقول أن
+
+44
+00:03:17,490 --> 00:03:27,700
+الوظيفة هي علاقةولكنها تجارب ثلاث جزء كما
+
+45
+00:03:27,700 --> 00:03:33,260
+ترى هنا، إنها تجارب ثلاث جزء اجنسية هي واحدة قطعة
+
+46
+00:03:33,260 --> 00:03:35,820
+في القانون التجاربي يمكن أن تكون في القانون
+
+47
+00:03:35,820 --> 00:03:39,620
+السياسي، نعم يمكن أن تكون مركزنا في القانون
+
+48
+00:03:39,620 --> 00:03:42,740
+التجاربي وكيف اجنسية واحدة قطعة أساسية في القانون
+
+49
+00:03:42,740 --> 00:03:49,690
+التجاربي، اجنسية مستخدمة أو مستخدمةthree partites
+
+50
+00:03:49,690 --> 00:03:53,210
+set of relationship contractual it comes from
+
+51
+00:03:53,210 --> 00:03:58,430
+contracts in which two sides a and b offer an
+
+52
+00:03:58,430 --> 00:04:02,650
+acceptance seller and buyer principal and agent
+
+53
+00:04:02,650 --> 00:04:06,090
+two one of them is making offer and the second is
+
+54
+00:04:06,090 --> 00:04:09,010
+making an acceptance that's a contract and we have
+
+55
+00:04:09,010 --> 00:04:12,910
+intention intention to make this contract by doing
+
+56
+00:04:12,910 --> 00:04:16,270
+this we have contractual there is something called
+
+57
+00:04:16,270 --> 00:04:21,850
+a quizzy contractهذا قليل من الصعب و سننظر عليه
+
+58
+00:04:21,850 --> 00:04:27,090
+كيف يمكن أن يكون مقاومة كويزي في حالة ما في حالة
+
+59
+00:04:27,090 --> 00:04:31,130
+ما، هذا سننظر عليه في القصة التالية عندما ندرس
+
+60
+00:04:31,130 --> 00:04:34,790
+مقاومة و كويزي مقاومة كما ترونها الأن هنا كويزي
+
+61
+00:04:34,790 --> 00:04:39,630
+مقاومة و في كل حالة في كل حالة، إنها مقاومة ثلاثية
+
+62
+00:04:39,630 --> 00:04:44,890
+أعضاء مقاومة ثلاثية أعضاء ماذا يعني؟ثلاث الأبعاد
+
+63
+00:04:44,890 --> 00:04:49,110
+look at this equation we have to use it all the
+
+64
+00:04:49,110 --> 00:05:00,210
+time principal agent and third part this equation
+
+65
+00:05:00,210 --> 00:05:05,190
+this tripartite set of relationship is usable all
+
+66
+00:05:05,190 --> 00:05:08,970
+the time we have to use it today and next time in
+
+67
+00:05:08,970 --> 00:05:12,950
+the next lecture because this can materialize
+
+68
+00:05:13,500 --> 00:05:18,920
+الهدف، عملنا، وعندما ندرس، نستطيع أن ندرس كيف تتجه
+
+69
+00:05:18,920 --> 00:05:22,640
+الأمور، في أي طريقة، كم صعب، كم سهل، هذا الموضوع
+
+70
+00:05:22,640 --> 00:05:27,740
+يمكن أن يكون مصممًا على هذا الشارت هذا الـ3
+
+71
+00:05:27,740 --> 00:05:35,120
+برطاية، واحد، اثنين، ثلاثة، مجتمع مجتمع موجود بين
+
+72
+00:05:35,120 --> 00:05:40,300
+الوظيفة الرئيسية، هذا هو الوظيفة هنا، كما ترى،
+
+73
+00:05:40,300 --> 00:05:40,860
+الوظيفة
+
+74
+00:05:45,020 --> 00:05:49,640
+agency it's between principal and agent what about
+
+75
+00:05:49,640 --> 00:05:52,680
+the customer what do you think the customer is the
+
+76
+00:05:52,680 --> 00:05:58,820
+customer with the third party is
+
+77
+00:05:58,820 --> 00:06:05,400
+he or she a part of this agency well he or she
+
+78
+00:06:05,400 --> 00:06:09,040
+will be involved somehow sometimes but agency it's
+
+79
+00:06:09,040 --> 00:06:12,740
+mainly between principal and agent I have a
+
+80
+00:06:12,740 --> 00:06:16,680
+businessI cannot work because I'm busy doing lots
+
+81
+00:06:16,680 --> 00:06:19,660
+of activities and I would need someone to act on
+
+82
+00:06:19,660 --> 00:06:23,260
+my behalf that person would be the agent and I
+
+83
+00:06:23,260 --> 00:06:28,840
+would be the principal principal and agent then
+
+84
+00:06:28,840 --> 00:06:32,480
+you can act on my behalf you can make your action
+
+85
+00:06:32,480 --> 00:06:38,640
+the agent would make a transaction deals deals
+
+86
+00:06:38,640 --> 00:06:44,560
+these deals would be with third partyالشيء الوحيد
+
+87
+00:06:44,560 --> 00:06:49,200
+اللي أستطيع أن أفعله هو أن أقبل شخص ما يكون مصطلحي
+
+88
+00:06:49,200 --> 00:06:50,720
+ليكون مصطلحي ليكون مصطلحي ليكون مصطلحي ليكون
+
+89
+00:06:50,720 --> 00:06:52,980
+مصطلحي ليكون مصطلحي ليكون مصطلحي ليكون مصطلحي
+
+90
+00:06:52,980 --> 00:06:52,980
+ليكون مصطلحي ليكون مصطلحي ليكون مصطلحي ليكون
+
+91
+00:06:52,980 --> 00:06:53,100
+مصطلحي ليكون مصطلحي ليكون مصطلحي ليكون مصطلحي
+
+92
+00:06:53,100 --> 00:06:56,180
+ليكون مصطلحي ليكون مصطلحي ليكون مصطلحي ليكون
+
+93
+00:06:56,180 --> 00:07:02,260
+مصطلحي ليكون مصطلحي ليكون مصطلحي ليكون مصطلحي
+
+94
+00:07:02,260 --> 00:07:12,320
+ليكون مصطلحي ليكون مصطلحي ليكون
+
+95
+00:07:12,320 --> 00:07:20,120
+مصبينهم في الحقيقة مصطلح ومصطلح ومصطلح مصطلح
+
+96
+00:07:20,120 --> 00:07:23,760
+ومصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+97
+00:07:23,760 --> 00:07:26,720
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+98
+00:07:26,720 --> 00:07:26,840
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+99
+00:07:26,840 --> 00:07:26,840
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+100
+00:07:26,840 --> 00:07:37,200
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطل
+
+101
+00:07:37,480 --> 00:07:42,720
+Explicitly or implicitly authorizes an agent to
+
+102
+00:07:42,720 --> 00:07:48,180
+work on his behalf To do what؟ What to do؟
+
+103
+00:07:48,180 --> 00:07:53,620
+Authorizing someone to act on my behalf for what؟
+
+104
+00:07:53,620 --> 00:07:54,540
+To make relationship,
+
+105
+00:07:57,500 --> 00:08:01,340
+transactions, deals with customers The same way
+
+106
+00:08:01,340 --> 00:08:05,680
+agent would do what؟ He will work .. it's the same
+
+107
+00:08:05,680 --> 00:08:10,390
+.. it's the same definitionو just swap swap بنغير
+
+108
+00:08:10,390 --> 00:08:15,210
+كلمة ممكن نغيرها swap the words agent is someone
+
+109
+00:08:15,210 --> 00:08:19,950
+is acting on behalf of the principal acting doing
+
+110
+00:08:19,950 --> 00:08:24,710
+what transactions deals with third parties third
+
+111
+00:08:24,710 --> 00:08:29,250
+parties it's kind of having sometimes negotiations
+
+112
+00:08:29,250 --> 00:08:34,470
+negotiating signing the contract making the deal
+
+113
+00:08:34,470 --> 00:08:38,480
+getting the money delivering the goodsوكل هذا يمكن
+
+114
+00:08:38,480 --> 00:08:43,400
+ان يكون فعله على حساب المصطلح
+
+115
+00:08:43,400 --> 00:08:54,440
+على حساب المصطلح هنا لدينا قوة هذه
+
+116
+00:08:54,440 --> 00:09:01,260
+القوة تم إعطائها للمصطلح من قبل المصطلح انها عملي
+
+117
+00:09:01,260 --> 00:09:07,620
+ومالي وعملي اعطي المصطلح القوةto act on my behalf
+
+118
+00:09:07,620 --> 00:09:10,440
+and he or she would follow what I'm saying would
+
+119
+00:09:10,440 --> 00:09:13,900
+have to abide everything is set to you you have to
+
+120
+00:09:13,900 --> 00:09:16,600
+abide by it otherwise I'm not going to be
+
+121
+00:09:16,600 --> 00:09:19,160
+responsible as a principal I should not be
+
+122
+00:09:19,160 --> 00:09:23,140
+responsible I would not be liable if my agent was
+
+123
+00:09:23,140 --> 00:09:27,560
+not following my instructions to be liable مسئول
+
+124
+00:09:27,560 --> 00:09:31,810
+irresponsibility here becausemy agent was
+
+125
+00:09:31,810 --> 00:09:35,250
+following my instructions but if he or she was not
+
+126
+00:09:35,250 --> 00:09:37,730
+following my instructions then it's not my
+
+127
+00:09:37,730 --> 00:09:40,370
+responsibility he's making a mistake he's making
+
+128
+00:09:40,370 --> 00:09:45,570
+the deal on his own name not my name so I don't
+
+129
+00:09:45,570 --> 00:09:49,190
+care about him and I will not be liable here look
+
+130
+00:09:49,190 --> 00:09:53,630
+at this look at the concept look at the meaning
+
+131
+00:09:53,630 --> 00:09:58,070
+why do we have agency this is the question people
+
+132
+00:09:58,070 --> 00:10:01,800
+asking alwayswhy do we have agency؟ why shouldn't
+
+133
+00:10:01,800 --> 00:10:08,220
+I make my own business؟ should we have agency؟
+
+134
+00:10:08,220 --> 00:10:12,380
+should we not have it at all؟ in the past people
+
+135
+00:10:12,380 --> 00:10:15,560
+did not have something like this well they do have
+
+136
+00:10:15,560 --> 00:10:18,460
+agency a long time ago but it's not in the modern
+
+137
+00:10:18,460 --> 00:10:22,300
+way we have it nowadays agency it's a necessity
+
+138
+00:10:22,300 --> 00:10:26,600
+it's important we cannot live in a market without
+
+139
+00:10:26,600 --> 00:10:31,390
+having agencyإلا لا يمكننا أن نعمل، انظر، أنا
+
+140
+00:10:31,390 --> 00:10:33,550
+بحاجة إلى شخص ما يقرر هذه الفترة لأجلي، إذا كنت
+
+141
+00:10:33,550 --> 00:10:37,050
+موجود هنا، شخص ما يريد أن يعمل.
+
+142
+00:10:45,390 --> 00:10:50,490
+نحن لدينا حقوق ومساعدات، كمساعدات، كمساعدات، نحن
+
+143
+00:10:50,490 --> 00:10:55,470
+لدينا حقوق ومساعدات، لكن هذه الحقوق ومساعدات
+
+144
+00:10:55,470 --> 00:11:00,400
+ستتفضلمحتاجات مجتمعية و حقيقتين مجتمعية و حقيقتين
+
+145
+00:11:00,400 --> 00:11:03,660
+محتاجات مجتمعية و حقيقتين محتاجات محتاجات محتاجات
+
+146
+00:11:03,660 --> 00:11:08,780
+محتاجات محتاجات محتاجات محتاجات محتاجات محتاجات
+
+147
+00:11:08,780 --> 00:11:08,880
+محتاجات محتاجات محتاجات محتاجات محتاجات محتاجات
+
+148
+00:11:08,880 --> 00:11:09,020
+محتاجات محتاجات محتاجات محتاجات محتاجات محتاجات
+
+149
+00:11:09,020 --> 00:11:09,020
+محتاجات محتاجات محتاجات محتاجات محتاجات محتاجات
+
+150
+00:11:09,020 --> 00:11:12,100
+محتاجات محتاجات محتاجات محتاجات محتاجات محتاجات
+
+151
+00:11:12,100 --> 00:11:18,340
+محتاجات محتاجات محتاجات محتاجات محتاجات محتاجات
+
+152
+00:11:18,340 --> 00:11:21,800
+محتاجات محتاجات محتاجات محتاجات محتاجات محتاجات
+
+153
+00:11:21,800 --> 00:11:25,540
+محتاجات
+
+154
+00:11:25,540 --> 00:11:29,400
+محتEngage in some other activities, he cannot
+
+155
+00:11:29,400 --> 00:11:31,580
+manage all his business, then he would need
+
+156
+00:11:31,580 --> 00:11:34,840
+somebody to help, someone to help If I have a
+
+157
+00:11:34,840 --> 00:11:37,620
+business and in having .. and have it in many
+
+158
+00:11:37,620 --> 00:11:40,520
+cities, in many countries, in many places, in many
+
+159
+00:11:40,520 --> 00:11:43,100
+markets, how can I .. how can I do it myself؟ I
+
+160
+00:11:43,100 --> 00:11:46,340
+would need some people to act on my behalf, those
+
+161
+00:11:46,340 --> 00:11:52,240
+people are my agents using my name or acting in my
+
+162
+00:11:52,240 --> 00:11:56,920
+name, I would be responsible for their actI will
+
+163
+00:11:56,920 --> 00:12:02,860
+be Now, because of these necessities and these
+
+164
+00:12:02,860 --> 00:12:06,120
+needs in the market, we would have legal reality
+
+165
+00:12:06,120 --> 00:12:09,960
+in which we have to accept this kind of
+
+166
+00:12:09,960 --> 00:12:13,680
+relationship between two agents and a principal in
+
+167
+00:12:13,680 --> 00:12:17,940
+which someone would embark upon .. embark .. what
+
+168
+00:12:17,940 --> 00:12:25,430
+is embark upon يصعد أو يقيم embark uponيقيم علاقات
+
+169
+00:12:25,430 --> 00:12:28,570
+يعني بركب on such transactions on behalf of
+
+170
+00:12:28,570 --> 00:12:32,970
+someone else of someone else in anyway sometimes
+
+171
+00:12:32,970 --> 00:12:35,230
+look at these two examples we have two examples
+
+172
+00:12:35,230 --> 00:12:40,570
+one person one person a man a lady a business
+
+173
+00:12:40,570 --> 00:12:44,390
+person cannot have his own way cannot deal with
+
+174
+00:12:44,390 --> 00:12:50,290
+all customers he have lots of items in many places
+
+175
+00:12:50,290 --> 00:12:53,550
+in the market in different locations at different
+
+176
+00:12:53,550 --> 00:12:58,740
+locationsin this case I will not be myself as a
+
+177
+00:12:58,740 --> 00:13:02,300
+principal at many places at the same time I cannot
+
+178
+00:13:02,300 --> 00:13:05,320
+be in Gaza city and in Khan Younis at the same
+
+179
+00:13:05,320 --> 00:13:09,640
+time I would need someone else to act on my behalf
+
+180
+00:13:09,640 --> 00:13:15,100
+there in this case I would employ somebody to be
+
+181
+00:13:15,100 --> 00:13:18,020
+my agent I would pay him money for that a
+
+182
+00:13:18,020 --> 00:13:21,760
+commission or fee a commission or fee it's a money
+
+183
+00:13:21,760 --> 00:13:26,170
+paid for that person for the agent to actبعض
+
+184
+00:13:26,170 --> 00:13:30,890
+المدرسات قالت إن هذا محتاج، إنه مهم لأنه بدون
+
+185
+00:13:30,890 --> 00:13:38,410
+مجلس، بدون مجلس، لن نتعرض للعمل، لن نتعرض له. إذا
+
+186
+00:13:38,410 --> 00:13:42,570
+كنت أملك 2 مليون دولار وكنت أرغب في الاستثمار فيهم
+
+187
+00:13:42,570 --> 00:13:48,490
+وكنت فقط لدي نفسي لأفعل على مجلسي و في إسمي، نفسي،
+
+188
+00:13:48,490 --> 00:13:51,650
+فلن أكون قادر على التعامل. إذا لم أكن أستطيع
+
+189
+00:13:51,650 --> 00:13:56,860
+استخدام مجلس على مجلسي، في السوق،ثم في هذه الحالة،
+
+190
+00:13:56,860 --> 00:14:00,160
+سأقوم بتخطيط عملتي، سأقوم بتخطيط شيء صغير من
+
+191
+00:14:00,160 --> 00:14:03,860
+مجتمعي، مجتمعي، مجتمعي، مجتمعي، مجتمعي، مجتمعي،
+
+192
+00:14:03,860 --> 00:14:04,880
+مجتمعي، مجتمعي، مجتمعي، مجتمعي، مجتمعي، مجتمعي،
+
+193
+00:14:04,880 --> 00:14:07,360
+مجتمعي، مجتمعي، مجتمعي، مجتمعي، مجتمعي، مجتمعي،
+
+194
+00:14:07,360 --> 00:14:07,460
+مجتمعي، مجتمعي، مجتمعي، مجتمعي، مجتمعي، مجتمعي،
+
+195
+00:14:07,460 --> 00:14:16,180
+مجتمعي، مجتمعي، مجتمعي، مجتمعي، مجتمعي،
+
+196
+00:14:16,180 --> 00:14:21,160
+مجتمعي، مجتمعي،
+
+197
+00:14:21,160 --> 00:14:23,300
+مج
+
+198
+00:14:24,910 --> 00:14:27,690
+الشركة تستطيع أن تشتر مقاعدات تستطيع أن تشتر
+
+199
+00:14:27,690 --> 00:14:29,670
+تستطيع أن تشتر شركة تستطيع أن تشتر شركة تستطيع أن
+
+200
+00:14:29,670 --> 00:14:30,010
+تشتر شركة تستطيع أن تشتر شركة تستطيع أن تشتر شركة
+
+201
+00:14:30,010 --> 00:14:34,310
+تستطيع أن تشتر شركة تستطيع أن تشتر شركة تستطيع أن
+
+202
+00:14:34,310 --> 00:14:34,850
+تشتر شركة تستطيع أن تشتر شركة تستطيع أن تشتر شركة
+
+203
+00:14:34,850 --> 00:14:35,530
+تستطيع أن تشتر شركة تستطيع أن تشتر شركة تستطيع أن
+
+204
+00:14:35,530 --> 00:14:36,650
+تشتر شركة تستطيع أن تشتر شركة تستطيع أن تشتر شركة
+
+205
+00:14:36,650 --> 00:14:45,150
+تستطيع أن تشتر شركة
+
+206
+00:14:45,150 --> 00:14:48,330
+تستطيع
+
+207
+00:14:48,330 --> 00:14:53,150
+أن
+
+208
+00:14:53,280 --> 00:14:56,380
+الذين يستطيعون أن يعملوا على مجلد .. على مجلد
+
+209
+00:14:56,380 --> 00:15:01,560
+الشركة، لذلك في حالات مثل هذه هنا، يجب أن نكون
+
+210
+00:15:01,560 --> 00:15:07,400
+لدينا مجلدين، إلا أننا سنغلق أعمالنا أو أننا سنكون
+
+211
+00:15:07,400 --> 00:15:12,480
+لدينا شركات صغيرة فقط، في هذه الحالة، يجب أن
+
+212
+00:15:12,480 --> 00:15:16,140
+نستخدم .. ما هو استخدام؟ تعرفين ما هو استخدام؟
+
+213
+00:15:16,140 --> 00:15:21,680
+استخدام .. الناس المستقلين يتمون من شركات يعملوا
+
+214
+00:15:21,680 --> 00:15:25,060
+على مجلدهمact on behalf .. you see here this
+
+215
+00:15:25,060 --> 00:15:31,260
+relationship be principal giving a agent authority
+
+216
+00:15:31,260 --> 00:15:35,060
+acting .. a is acting on behalf of the principal
+
+217
+00:15:35,060 --> 00:15:38,580
+.. simple .. acting on behalf of the principal ..
+
+218
+00:15:38,580 --> 00:15:42,500
+but there is something important here .. liability
+
+219
+00:15:42,500 --> 00:15:44,940
+.. this liability if you can see it between
+
+220
+00:15:44,940 --> 00:15:48,580
+principal and the customer .. how can we establish
+
+221
+00:15:50,100 --> 00:15:55,720
+التواصل بين الرئيس و المستخدم إذا كان الرئيس لم
+
+222
+00:15:55,720 --> 00:16:00,300
+يشرح التعامل التعامل كان انظر لهذا التعامل كان بين
+
+223
+00:16:00,300 --> 00:16:06,540
+الوظيفة و المستخدم هذا هو التعامل ماذا عن الرئيس
+
+224
+00:16:06,540 --> 00:16:10,760
+الذي لم يشرح أي شيء؟ لم يقوم بأي تعامل أو أي تعامل
+
+225
+00:16:10,760 --> 00:16:17,660
+مع المستخدم هل هو سيكون مخطط؟ هل هو سيكون مسؤول؟
+
+226
+00:16:17,660 --> 00:16:36,080
+نعمwhy is .. why is .. بون wake up okay
+
+227
+00:16:36,080 --> 00:16:41,000
+not
+
+228
+00:16:41,000 --> 00:16:46,440
+exactly no anyone here someone having someone
+
+229
+00:16:46,440 --> 00:16:51,190
+what's your name ألاShe's my agent. She's acting
+
+230
+00:16:51,190 --> 00:16:55,590
+on my behalf. She can make a transaction with all
+
+231
+00:16:55,590 --> 00:17:00,790
+of you. Today she signed five contracts with some
+
+232
+00:17:00,790 --> 00:17:05,070
+of you. She signed the contract on my behalf. I
+
+233
+00:17:05,070 --> 00:17:07,870
+was not here. I was somewhere else. But she was
+
+234
+00:17:07,870 --> 00:17:11,090
+acting on my behalf. When I came back to my place
+
+235
+00:17:11,090 --> 00:17:14,970
+here and I found Ala signed five contracts. Will I
+
+236
+00:17:14,970 --> 00:17:19,830
+be responsible for these contracts or not? Yes?yes
+
+237
+00:17:19,830 --> 00:17:25,630
+good why؟ okay جيدة you are responsible for the
+
+238
+00:17:25,630 --> 00:17:28,390
+agent because the agent is supposed to follow your
+
+239
+00:17:28,390 --> 00:17:32,830
+instructions okay so normally you are responsible
+
+240
+00:17:32,830 --> 00:17:39,270
+and liable for his contracts I give him the
+
+241
+00:17:39,270 --> 00:17:42,770
+instructions I give my agent as a principal giving
+
+242
+00:17:42,770 --> 00:17:48,530
+my agent instructions information ordersshe or he
+
+243
+00:17:48,530 --> 00:17:53,530
+has to follow my instructions as long as my agent
+
+244
+00:17:53,530 --> 00:17:58,710
+was following my instructions I will be liable
+
+245
+00:17:58,710 --> 00:18:04,150
+liability meaning legal responsibility I will have
+
+246
+00:18:04,150 --> 00:18:07,390
+to pay I will have to be responsible I give you a
+
+247
+00:18:07,390 --> 00:18:10,470
+simple example simple example for example like
+
+248
+00:18:10,470 --> 00:18:17,080
+having my business working 15 hours per dayfrom
+
+249
+00:18:17,080 --> 00:18:19,000
+eight o'clock in the morning till evening time
+
+250
+00:18:19,000 --> 00:18:24,120
+working over two shifts one in the morning and one
+
+251
+00:18:24,120 --> 00:18:29,840
+in the afternoon until evening I was doing my part
+
+252
+00:18:29,840 --> 00:18:33,360
+at the evening time ألأ she was working in the
+
+253
+00:18:33,360 --> 00:18:38,220
+morning in the morning now someone came to our
+
+254
+00:18:38,220 --> 00:18:42,860
+store bought a laptop and ألأ signed a contract
+
+255
+00:18:42,860 --> 00:18:45,800
+and the customer paid the money and she gave the
+
+256
+00:18:45,800 --> 00:18:50,190
+laptopالعزيزي كان يجد شيء مخاطر مع الكمبيوتر أو
+
+257
+00:18:50,190 --> 00:18:55,790
+مخطط، لم يعمل، لم يعمل جيدًا، لم يكن نفس القوة،
+
+258
+00:18:55,790 --> 00:18:59,930
+فالعزيزي يستطيع أن يعود إليّ في الوقت الليلي، في
+
+259
+00:18:59,930 --> 00:19:02,770
+هذه الحالة أو في هذه الوقت، هل أستطيع أن أقول
+
+260
+00:19:02,770 --> 00:19:08,110
+للعزيزي لا، أنا لن أقبل ذلك؟ سأجب أن أقبل ذلك،
+
+261
+00:19:08,110 --> 00:19:13,250
+لأنه مسؤوليتي. في الوقت الصباح، ألأ كان عملي و أنا
+
+262
+00:19:13,250 --> 00:19:17,290
+لم أكن هناك، لكنها كانت تعمل على مجاليit's my
+
+263
+00:19:17,290 --> 00:19:20,690
+business and I authorized her I gave her all the
+
+264
+00:19:20,690 --> 00:19:23,650
+information she was following my instructions the
+
+265
+00:19:23,650 --> 00:19:29,170
+customer was doing his part innocently paying the
+
+266
+00:19:29,170 --> 00:19:33,090
+money getting the good it was not good it does not
+
+267
+00:19:33,090 --> 00:19:37,310
+match the quality I can take my goods back my item
+
+268
+00:19:37,310 --> 00:19:40,010
+back and I will pay the money back to the customer
+
+269
+00:19:40,010 --> 00:19:44,330
+or I can exchange it I can replace it I can fix it
+
+270
+00:19:44,330 --> 00:19:48,480
+for the customerI will have to be responsible for
+
+271
+00:19:48,480 --> 00:19:54,840
+my agent as long as what؟ as long as I'm not
+
+272
+00:19:54,840 --> 00:20:00,660
+follow me؟ principle will be responsible towards
+
+273
+00:20:00,660 --> 00:20:04,240
+anything has been done by the agent as commercial
+
+274
+00:20:04,240 --> 00:20:10,820
+transactions as long as the agent was was
+
+275
+00:20:10,820 --> 00:20:14,000
+following the instructions was listening to the
+
+276
+00:20:14,000 --> 00:20:17,530
+principle you understand what I'm saying؟هل انت
+
+277
+00:20:17,530 --> 00:20:23,470
+متأكد؟ لا؟ حسنا، هل يمكن أن أحد يقولها مرة أخرى؟
+
+278
+00:20:23,470 --> 00:20:23,970
+هل يمكن أن أحد يقولها مرة أخرى؟ هل يمكن أن أحد
+
+279
+00:20:23,970 --> 00:20:27,750
+يقولها مرة أخرى؟ هل يمكن أن أحد يقولها مرة أخرى؟
+
+280
+00:20:27,750 --> 00:20:30,030
+هل يمكن أن أحد يقولها مرة أخرى؟ هل يمكن أن أحد
+
+281
+00:20:30,030 --> 00:20:30,890
+يقولها مرة أخرى؟ هل يمكن أن أحد يقولها مرة أخرى؟
+
+282
+00:20:30,890 --> 00:20:31,050
+هل يمكن أن أحد يقولها مرة أخرى؟ هل يمكن أن أحد
+
+283
+00:20:31,050 --> 00:20:31,050
+يقولها مرة أخرى؟ هل يمكن أن أحد يقولها مرة أخرى؟
+
+284
+00:20:31,050 --> 00:20:31,490
+هل يمكن أن أحد يقولها مرة أخرى؟ هل يمكن أن أحد
+
+285
+00:20:31,490 --> 00:20:40,470
+يقولها مرة أخرى؟ هل يمكن أن أحد يقولها مرة
+
+286
+00:20:40,470 --> 00:20:47,130
+أخرى؟ ه
+
+287
+00:20:49,530 --> 00:20:55,230
+لدينا اتفاق هذا الاتفاق كان مجرد اتفاق بين مجلد و
+
+288
+00:20:55,230 --> 00:20:59,230
+مستخدم انه اتفاق انه اتفاق انه اتفاق انه اتفاق انه
+
+289
+00:20:59,230 --> 00:21:00,870
+اتفاق انه اتفاق انه اتفاق انه اتفاق انه اتفاق انه
+
+290
+00:21:00,870 --> 00:21:05,450
+اتفاق انه اتفاق انه اتفاق انه اتفاق انه اتفاق انه
+
+291
+00:21:05,450 --> 00:21:05,690
+اتفاق انه اتفاق انه اتفاق انه اتفاق انه اتفاق انه
+
+292
+00:21:05,690 --> 00:21:07,030
+اتفاق انه اتفاق انه اتفاق انه اتفاق انه اتفاق انه
+
+293
+00:21:07,030 --> 00:21:18,710
+اتفاق انه اتفاق انه اتفاق ان
+
+294
+00:21:18,970 --> 00:21:22,790
+the customer the same responsibility with her سواء
+
+295
+00:21:22,790 --> 00:21:26,750
+يعني she has done it as my agent or I have done it
+
+296
+00:21:26,750 --> 00:21:29,950
+as a principal it's the same thing the same
+
+297
+00:21:29,950 --> 00:21:33,070
+responsibility that's the main result okay
+
+298
+00:21:33,070 --> 00:21:42,270
+understood no good looking
+
+299
+00:21:42,270 --> 00:21:46,940
+back hereانظر إلى هذه المقالة مره و مره تجد
+
+300
+00:21:46,940 --> 00:21:54,200
+المستخدم ثالث مجتمع انه او انها في بعض الأحيان غير
+
+301
+00:21:54,200 --> 00:21:58,580
+عذرين و في بعض الأحيان غير عذرين يجب أن نبحث عن
+
+302
+00:21:58,580 --> 00:22:02,740
+المستخدم يجب أن نهتم بعد مستخدمنا لأن إذا فاترناهم
+
+303
+00:22:02,740 --> 00:22:05,340
+لا يمكننا أن نعمل في السوق لا يمكننا أن نعمل في
+
+304
+00:22:05,340 --> 00:22:10,200
+مجتمعنا يمكننا أن نغلق عملنا مستخدمنا هم شيء قوي
+
+305
+00:22:10,200 --> 00:22:13,120
+يحافظ عليهم ويحافظ على أكتر مستخدم
+
+306
+00:22:17,320 --> 00:22:24,640
+لذالك إذا كان الشرطة تعمل بطريقة عظيمة إذا كان
+
+307
+00:22:24,640 --> 00:22:33,000
+الشرطة تعمل بدون شرطة أو ربما الشرطة تتجاوز القوة
+
+308
+00:22:35,500 --> 00:22:40,560
+أو الشرطة تقوم بتقديم المعلومات و هو او هي لم تتبع
+
+309
+00:22:40,560 --> 00:22:44,300
+معلوماتي و الشرطة قامت بالتعامل مع المستخدم ماذا
+
+310
+00:22:44,300 --> 00:22:48,940
+يمكننا أن نفعل بها؟ اعطيت الشرطة بعض المعلومات
+
+311
+00:22:48,940 --> 00:22:53,900
+اعطيت جايدة هذه اللابتوب و 5 آخر لابتوب و طلبت
+
+312
+00:22:53,900 --> 00:22:59,170
+منها أن تسحق كل واحد منهم لـ 600$وطلبت منها أن
+
+313
+00:22:59,170 --> 00:23:04,430
+تشرح للمستخدمين قيمته ومعروفه ومعروفه ومعروفه
+
+314
+00:23:04,430 --> 00:23:05,150
+ومعروفه ومعروفه ومعروفه ومعروفه ومعروفه ومعروفه
+
+315
+00:23:05,150 --> 00:23:05,770
+ومعروفه ومعروفه ومعروفه ومعروفه ومعروفه ومعروفه
+
+316
+00:23:05,770 --> 00:23:05,990
+ومعروفه ومعروفه ومعروفه ومعروفه ومعروفه ومعروفه
+
+317
+00:23:05,990 --> 00:23:06,610
+ومعروفه ومعروفه ومعروفه ومعروفه ومعروفه ومعروفه
+
+318
+00:23:06,610 --> 00:23:08,110
+ومعروفه ومعروفه ومعروفه ومعروفه ومعروفه ومعروفه
+
+319
+00:23:08,110 --> 00:23:25,730
+ومعروفه و
+
+320
+00:23:29,440 --> 00:23:36,680
+طالما ان المستخدم كان بخالص و صادق و لا يعرف اذا
+
+321
+00:23:36,680 --> 00:23:41,660
+جايدا كانت لديها صديقة اسمها اروى و قامت بتسليط
+
+322
+00:23:41,660 --> 00:23:47,820
+هذه اللابتوب لأروى لـ 300$ فقط اذا كانت اروى بخالص
+
+323
+00:23:47,820 --> 00:23:51,960
+و كانت شخصية صادقة فهي كانت ممكن تحافظ عليه فهي
+
+324
+00:23:51,960 --> 00:23:55,240
+كانت ممكن تحافظ على اللابتوب انه لابتوب صحيح فهي
+
+325
+00:23:55,240 --> 00:23:58,640
+فقط جاءت إلى مكان العملتبقى مالها وشوفت الكمبيوتر
+
+326
+00:23:58,640 --> 00:24:03,000
+وذهبت للمنزل وقال انها كمبيوتر لها و مصطلحي كان
+
+327
+00:24:03,000 --> 00:24:07,200
+يفعل خطأ اذا كنت انا كنت افعل خطأ اذا كنت انا كنت
+
+328
+00:24:07,200 --> 00:24:08,100
+افعل خطأ اذا كنت افعل خطأ اذا كنت افعل خطأ اذا كنت
+
+329
+00:24:08,100 --> 00:24:08,360
+افعل خطأ اذا كنت افعل خطأ اذا كنت افعل خطأ اذا كنت
+
+330
+00:24:08,360 --> 00:24:10,040
+افعل خطأ اذا كنت افعل خطأ اذا كنت افعل خطأ اذا كنت
+
+331
+00:24:10,040 --> 00:24:11,760
+افعل خطأ اذا كنت افعل خطأ اذا كنت افعل خطأ اذا كنت
+
+332
+00:24:11,760 --> 00:24:18,000
+افعل خطأ اذا كنت افعل خطأ اذا
+
+333
+00:24:18,000 --> 00:24:23,660
+كنت افعل خطأ اذا
+
+334
+00:24:23,660 --> 00:24:29,270
+كنت اعرفت منذ البداية أن هناك شيء غير صحيح وكانت
+
+335
+00:24:29,270 --> 00:24:33,710
+تتأمر مع
+
+336
+00:24:33,710 --> 00:24:39,870
+الموظفين في هذه اللحظة بإمكاني أن أتبع المستخدم
+
+337
+00:24:39,870 --> 00:24:45,150
+بإمكاني أن أأخذ أسلوب من المستخدم ننظر هنا
+
+338
+00:24:45,150 --> 00:24:50,090
+للمستخدم إذا كان او انها كانت مغفرة أو لم تكن
+
+339
+00:24:50,090 --> 00:24:53,860
+مغفرةand it says here if you look at this sentence
+
+340
+00:24:53,860 --> 00:25:05,120
+can you read it اوه in any
+
+341
+00:25:05,120 --> 00:25:08,400
+case it's not difficult to know if someone is an
+
+342
+00:25:08,400 --> 00:25:12,980
+agent or not it's not difficult you can you can
+
+343
+00:25:12,980 --> 00:25:17,480
+look at the situation i can understand if ala is
+
+344
+00:25:17,480 --> 00:25:22,200
+an agent or notأنا أستطيع أن أشاهد مثلًا .. نحن
+
+345
+00:25:22,200 --> 00:25:25,120
+لدينا .. نحن لدينا بعض الأمثلة لاحقًا .. نحن لدينا
+
+346
+00:25:25,120 --> 00:25:30,680
+ثلاثة نوعين من الحكومات، ثلاثة نوعين من الأشخاص،
+
+347
+00:25:30,680 --> 00:25:35,660
+سنشاهدهم كيف يمكن أن يكون أحدهم شخصًا شخصًا وكيف
+
+348
+00:25:35,660 --> 00:25:40,040
+كثير حكومة تحتوي عليها، كم قوة تحتوي عليها، كيف
+
+349
+00:25:40,040 --> 00:25:42,760
+يمكن أن تتعامل معها، سنشاهد الحالة والوضع،
+
+350
+00:25:42,760 --> 00:25:45,710
+وسأشاهدكI can understand it's not difficult it's
+
+351
+00:25:45,710 --> 00:25:48,830
+not cost effect مش هتكلفني كتير to understand if
+
+352
+00:25:48,830 --> 00:25:51,770
+she is an agent or not if she was deceiving me
+
+353
+00:25:51,770 --> 00:25:56,510
+well I can't do anything about it I can't check at
+
+354
+00:25:56,510 --> 00:26:07,770
+least here look again here go on anyone consent
+
+355
+00:26:07,770 --> 00:26:11,370
+consent acceptance
+
+356
+00:26:15,250 --> 00:26:19,970
+هذا نقطة جيدة هنا إذا كانت تظهر لاحقًا، لاحقًا نجد
+
+357
+00:26:19,970 --> 00:26:25,890
+أن الوظيفة .. انظر إلى هذا هنا، الوظيفة كانت تعمل
+
+358
+00:26:25,890 --> 00:26:34,060
+بدون وظيفة، بدون .. لا يوجد حكمwas exceeding the
+
+359
+00:26:34,060 --> 00:26:36,720
+authority I told you what to do exactly but you
+
+360
+00:26:36,720 --> 00:26:39,160
+will not follow my instructions you did something
+
+361
+00:26:39,160 --> 00:26:42,980
+else agent was not following the instructions the
+
+362
+00:26:42,980 --> 00:26:45,560
+agent has no authority here later on that the
+
+363
+00:26:45,560 --> 00:26:50,660
+agent was acting without consent consent قبولة
+
+364
+00:26:50,660 --> 00:26:54,660
+acceptance of the principal in this case who will
+
+365
+00:26:54,660 --> 00:26:57,560
+be liable the agent or the principal agent if he
+
+366
+00:26:57,560 --> 00:27:01,140
+makes a mistake the agent he will be liable for
+
+367
+00:27:01,140 --> 00:27:05,610
+that mistakeلكن في المرة القادمة عندما ننظر إلى
+
+368
+00:27:05,610 --> 00:27:09,630
+المقالات
+
+369
+00:27:09,630 --> 00:27:12,250
+التالية التي ستكون في المرة التالية ، سنرى أن في
+
+370
+00:27:12,250 --> 00:27:18,610
+كلا الحالات أحياناً مؤسسة ومؤسسة ستكون قابل للشخص
+
+371
+00:27:18,610 --> 00:27:23,210
+المستخدم. كلا هما في نفس الوقت سيكون لديهم قابل
+
+372
+00:27:23,210 --> 00:27:29,020
+للشخص المستخدم لأننا يجب أن نبحث عن شركة أخرى.in
+
+373
+00:27:29,020 --> 00:27:31,940
+this case if the agent anyway he makes a mistake
+
+374
+00:27:31,940 --> 00:27:36,580
+he does not follow the instruction exceeds those
+
+375
+00:27:36,580 --> 00:27:40,700
+orders then he or she will be liable for
+
+376
+00:27:40,700 --> 00:27:44,220
+compensation for compensation so by this we can
+
+377
+00:27:44,220 --> 00:27:47,360
+understand at least that agency is something
+
+378
+00:27:47,360 --> 00:27:51,420
+necessary something important in the market we
+
+379
+00:27:51,420 --> 00:27:54,140
+cannot function we cannot work without agency
+
+380
+00:27:54,560 --> 00:27:58,560
+نحتاجها في مستوى الشخصي نحتاجها في مستوى
+
+381
+00:27:58,560 --> 00:28:03,320
+الانستجرام و سنكون لدينا بعض الأمثلة لاحقا عن بعض
+
+382
+00:28:03,320 --> 00:28:08,120
+الشركات و هذه الشركات تجد ان بعض الاشخاص يعملون
+
+383
+00:28:08,120 --> 00:28:13,120
+على دسك و يعملون خلف الـ till ذلك الشخص يملك القوة
+
+384
+00:28:13,120 --> 00:28:14,240
+مثل مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+385
+00:28:14,240 --> 00:28:17,120
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+386
+00:28:17,120 --> 00:28:17,140
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+387
+00:28:17,140 --> 00:28:20,820
+مجرد مجرد
+
+388
+00:28:20,820 --> 00:28:23,960
+مجر
+
+389
+00:28:24,000 --> 00:28:28,720
+او اذا كنت ترغب في اشتراك شرطة لديها رسالة أشهر،
+
+390
+00:28:28,720 --> 00:28:31,240
+او شرطة أشهر، او شرطة أشهر، او شرطة أشهر، او شرطة
+
+391
+00:28:31,240 --> 00:28:32,840
+أشهر، او شرطة أشهر، او شرطة أشهر، او شرطة أشهر، او
+
+392
+00:28:32,840 --> 00:28:36,260
+شرطة أشهر، او شرطة أشهر، او شرطة أشهر، او شرطة
+
+393
+00:28:36,260 --> 00:28:40,420
+أشهر، او شرطة أشهر، او شرطة أشهر، او شرطة أشهر، او
+
+394
+00:28:40,420 --> 00:28:45,000
+شرطة أشهر، او شرطة أشهر، او شرطة أشهر، او شرط
+
+395
+00:28:46,320 --> 00:28:50,700
+الشركة نفسها ستكون مسؤولة عن أي خطأ يمكن ان يكون
+
+396
+00:28:50,700 --> 00:28:53,940
+فعله من أعمال الوظيفة لشركة الوظيفة لشركة الوظيفة
+
+397
+00:28:53,940 --> 00:28:58,900
+لشركة الوظيفة لشركة الوظيفة لشركة الوظيفة لشركة
+
+398
+00:28:58,900 --> 00:29:02,960
+الوظيفة لشركة الوظيفة لشركة الوظيفة لشركة الوظيفة
+
+399
+00:29:02,960 --> 00:29:02,960
+لشركة الوظيفة لشركة الوظيفة لشركة الوظيفة لشركة
+
+400
+00:29:02,960 --> 00:29:02,960
+الوظيفة لشركة الوظيفة لشركة الوظيفة لشركة الوظيفة
+
+401
+00:29:02,960 --> 00:29:03,940
+لشركة الوظيفة لشركة الوظيفة لشركة الوظيفة لشركة
+
+402
+00:29:03,940 --> 00:29:11,000
+الوظيفة لشركة الوظيف
+
+403
+00:29:11,150 --> 00:29:16,550
+هل انا و انت ممكن نكون رئيس؟ ممكن تكون شركة ممكن
+
+404
+00:29:16,550 --> 00:29:19,330
+تكون شركة ممكن تكون رئيس؟ من ممكن يكون رئيس؟ كيف
+
+405
+00:29:19,330 --> 00:29:25,730
+يمكننا أن ندفعها؟ نعم
+
+406
+00:29:25,730 --> 00:29:29,550
+اي شخص ممكن يكون رئيس ممكن تكون شركة ممكن تكون
+
+407
+00:29:29,550 --> 00:29:30,170
+شركة ممكن تكون شركة ممكن تكون شركة ممكن تكون شركة
+
+408
+00:29:30,170 --> 00:29:32,110
+ممكن تكون شركة ممكن تكون شركة ممكن تكون شركة ممكن
+
+409
+00:29:32,110 --> 00:29:32,170
+تكون شركة ممكن تكون شركة ممكن تكون شركة ممكن تكون
+
+410
+00:29:32,170 --> 00:29:32,170
+شركة ممكن تكون شركة ممكن تكون شركة ممكن تكون شركة
+
+411
+00:29:32,170 --> 00:29:32,290
+ممكن تكون شركة ممكن تكون شركة ممكن تكون شركة ممكن
+
+412
+00:29:32,290 --> 00:29:36,870
+تكون شركة ممكن تكون شركة ممكن تكون شركة م
+
+413
+00:29:41,210 --> 00:29:46,070
+أي شخص يمكن أن يكون رئيس، لكن نستطيع أن ندفعه كشخص
+
+414
+00:29:46,070 --> 00:29:51,550
+يمكن أن يكون شخص طبيعي، إنه إنسان، و يمكن أن يكون
+
+415
+00:29:51,550 --> 00:29:58,170
+شخص مخطط مثل شركة و هذا الشخص مخطط أو غير مخطط
+
+416
+00:29:58,170 --> 00:30:04,790
+الذي يسمح لشركة اشخاص يسمح لشركة اشخاص يعملوا
+
+417
+00:30:04,790 --> 00:30:11,070
+لإنشاء واحد او أكتر علاقة عامة مع الشركة الثالثة
+
+418
+00:30:12,070 --> 00:30:17,630
+عندما ننظر إلى مصطلح الوظيفة نجدها نفس الشيء، نغير
+
+419
+00:30:17,630 --> 00:30:24,690
+بعض الكلمات، نحن لدينا مصطلح، ووظيفة، ثالث مجتمع،
+
+420
+00:30:24,690 --> 00:30:32,490
+ومقاومة، وهكذا، هذا هو المصطلح، شخص، شخص، شخص
+
+421
+00:30:32,490 --> 00:30:36,190
+مخطط، مخطط،
+
+422
+00:30:36,190 --> 00:30:36,450
+مخطط، مخطط، مخطط، مخطط، مخطط، مخطط، مخطط، مخطط،
+
+423
+00:30:36,450 --> 00:30:36,830
+مخطط، مخطط، مخطط، مخطط، مخطط، مخطط، مخطط، مخطط،
+
+424
+00:30:36,830 --> 00:30:40,160
+مخطط، مخطط، مخطط، مخطط، مخطط، مخطط، مخطط، مخطط،to
+
+425
+00:30:40,160 --> 00:30:45,120
+create one or more legal relationship with third
+
+426
+00:30:45,120 --> 00:30:54,780
+party merchants can be principals okay who is a
+
+427
+00:30:54,780 --> 00:31:00,780
+merchant if a merchant is a principal so who is
+
+428
+00:31:00,780 --> 00:31:08,720
+the merchant can you be a merchanta merchant is a
+
+429
+00:31:08,720 --> 00:31:12,280
+trader and his goal is to make profit in a
+
+430
+00:31:12,280 --> 00:31:16,620
+professional way and he constantly does it and he
+
+431
+00:31:16,620 --> 00:31:19,880
+is giving great dealings to people many times over
+
+432
+00:31:19,880 --> 00:31:24,920
+again and he sometimes makes to come home and say
+
+433
+00:31:24,920 --> 00:31:30,200
+to the merchant that he is ashamed to say that to
+
+434
+00:31:30,200 --> 00:31:31,420
+the merchant and the people
+
+435
+00:31:47,750 --> 00:31:50,130
+Okay we will look at the definition of merchant
+
+436
+00:31:50,130 --> 00:31:53,510
+anyone can be a merchant but you have to have some
+
+437
+00:31:53,510 --> 00:31:57,670
+conditions some condition you have to work in
+
+438
+00:31:57,670 --> 00:32:01,620
+business for a time in which peopleget to
+
+439
+00:32:01,620 --> 00:32:05,480
+understand that you are a merchant not for once
+
+440
+00:32:05,480 --> 00:32:10,000
+not for twice it's for a long time in which people
+
+441
+00:32:10,000 --> 00:32:12,940
+in the society can understand that Jayda is a
+
+442
+00:32:12,940 --> 00:32:17,380
+merchant or Ala is a merchant and at the same time
+
+443
+00:32:17,380 --> 00:32:20,340
+you have to follow the conditions legal conditions
+
+444
+00:32:20,340 --> 00:32:24,160
+you have to abide by them one of them is your name
+
+445
+00:32:24,160 --> 00:32:27,240
+has to be registered at the chamber of commerce
+
+446
+00:32:27,240 --> 00:32:32,640
+one of them as well can be it has to beأسمك يجب أن
+
+447
+00:32:32,640 --> 00:32:39,100
+تكون محفظًا في مكتب المحفظة في مدينة Economics ثم
+
+448
+00:32:39,100 --> 00:32:43,120
+نقطة أخرى يجب أن تأخذ كل المعلومات المحتاجة
+
+449
+00:32:43,120 --> 00:32:49,420
+لتتبعها لتأخذ مقالات لتكتب مقالات في مقالات خاصة
+
+450
+00:32:49,420 --> 00:32:55,880
+كل هذه المقالات هي مقالات محتاجة لكي تصبح محافظًا
+
+451
+00:32:55,880 --> 00:33:03,760
+لنا لدينا محافظة مخصصة و لديناretail merchants a
+
+452
+00:33:03,760 --> 00:33:07,460
+wholesale merchant is someone buying goods or
+
+453
+00:33:07,460 --> 00:33:14,700
+items from factory and selling them to a retailer
+
+454
+00:33:14,700 --> 00:33:18,340
+someone having a link in the middle between
+
+455
+00:33:18,340 --> 00:33:21,920
+manufacturing between between production
+
+456
+00:33:21,920 --> 00:33:26,960
+production line and retailer and a second type
+
+457
+00:33:26,960 --> 00:33:33,070
+which is a retail merchant or retailerنحن لدينا
+
+458
+00:33:33,070 --> 00:33:37,170
+شركات عظيمة وشركات عظيمة وشركات عظيمة وشركات عظيمة
+
+459
+00:33:37,170 --> 00:33:41,030
+وشركات عظيمة وشركات عظيمة وشركات عظيمة وشركات
+
+460
+00:33:41,030 --> 00:33:42,510
+عظيمة وشركات عظيمة وشركات عظيمة وشركات عظيمة
+
+461
+00:33:42,510 --> 00:33:42,890
+وشركات عظيمة وشركات عظيمة وشركات عظيمة وشركات
+
+462
+00:33:42,890 --> 00:33:42,930
+عظيمة وشركات عظيمة وشركات عظيمة وشركات عظيمة
+
+463
+00:33:42,930 --> 00:33:43,730
+وشركات عظيمة وشركات عظيمة وشركات عظيمة وشركات
+
+464
+00:33:43,730 --> 00:33:43,890
+عظيمة وشركات عظيمة وشركات عظيمة وشركات عظيمة
+
+465
+00:33:43,890 --> 00:34:01,090
+وشركات عظيمة وشركات عظيمة وشرك
+
+466
+00:34:02,040 --> 00:34:06,420
+to invest still he or she will be called a
+
+467
+00:34:06,420 --> 00:34:10,000
+merchant with following where the conditions
+
+468
+00:34:10,000 --> 00:34:13,600
+needed but some of them spent a hell of money
+
+469
+00:34:13,600 --> 00:34:17,880
+millions and millions of dollars and those at the
+
+470
+00:34:17,880 --> 00:34:21,480
+same time are called merchant in the past looking
+
+471
+00:34:21,480 --> 00:34:25,540
+at classification in pre-modern societies we have
+
+472
+00:34:25,540 --> 00:34:29,520
+high and low classes high and low class high class
+
+473
+00:34:29,520 --> 00:34:35,100
+used to be calledميرشوند برنز ميرشوند برنز و يمكنك
+
+474
+00:34:35,100 --> 00:34:40,220
+أن ترى ان اليوم المعروفين الميرشوند يمكنهم الذهاب
+
+475
+00:34:40,220 --> 00:34:44,580
+لأي مكان في العالم يمكنهم أن يشتري أي شيء يحبونه
+
+476
+00:34:44,580 --> 00:34:49,340
+يمكنهم أن يكونوا في اتصال مع الكثير من الناس في
+
+477
+00:34:49,340 --> 00:34:52,100
+مدرسات مختلفة مستوى مختلف يمكنهم أن يعملوا في
+
+478
+00:34:52,100 --> 00:34:56,020
+الحكومة لاحقا يمكنهم أن يشتري أي شيء يريدونه هؤلاء
+
+479
+00:34:56,020 --> 00:35:01,640
+ميرشوند عظيمين نسميهمميرشاند برنسا وحتى بعضهم
+
+480
+00:35:01,640 --> 00:35:08,300
+بعضهم جمال ميرشاند مثل استخدام صفر قيمة صغيرة صفر
+
+481
+00:35:08,300 --> 00:35:14,720
+قيمة صغيرة لتستخدمها في الولايات المتحدة هناك
+
+482
+00:35:14,720 --> 00:35:22,740
+مفهوم لميرشاند كان مدفن انه اي شخص اي شخص بينما
+
+483
+00:35:22,740 --> 00:35:28,570
+يتعامل بالعمل او العملAny person engaged in
+
+484
+00:35:28,570 --> 00:35:34,190
+business or profession or seller who deals in a
+
+485
+00:35:34,190 --> 00:35:38,410
+type of goods sold So it's not different from what
+
+486
+00:35:38,410 --> 00:35:41,670
+we said before it's similar someone engaged in
+
+487
+00:35:41,670 --> 00:35:45,110
+business spending my time doing business buying
+
+488
+00:35:45,110 --> 00:35:51,610
+selling here goods type of goods sold I
+
+489
+00:35:51,610 --> 00:35:55,530
+know those merchants have some inequalities in
+
+490
+00:35:55,530 --> 00:36:01,450
+lifeهم لديهم فرصة أكتر من الناس الاخرين لديهم
+
+491
+00:36:01,450 --> 00:36:07,510
+مواقع خاصة ليس شيء لا يجب أن نعرفه إنه نقطة بسيطة
+
+492
+00:36:07,510 --> 00:36:12,270
+يمكننا أن نعتمد عليه تلك المواقع الخاصة الخاصة
+
+493
+00:36:12,270 --> 00:36:15,570
+التي تسمح لهم بالاستثمار من المال تسمح لهم
+
+494
+00:36:15,570 --> 00:36:21,230
+باستخدام قدرتهم الخاصة لتغطي المال لوقت قصير أو
+
+495
+00:36:21,230 --> 00:36:28,170
+لوقت طويلوهو يعتمد على التعامل مع البنك لأن انا
+
+496
+00:36:28,170 --> 00:36:31,830
+اعرف ان بعض الشركات هم في عقد يمكنهم أن يكونوا في
+
+497
+00:36:31,830 --> 00:36:35,530
+عقد من وقت لوقت ولكنهم لديهم دفع من البنك والبنك
+
+498
+00:36:35,530 --> 00:36:40,930
+يمكنه أن يغطيهم النقطة الأخيرة عن الشركات هي أن
+
+499
+00:36:40,930 --> 00:36:47,850
+بعضهم يمكن أن يسمونها شخص عملي هل انت بخير؟ هل
+
+500
+00:36:47,850 --> 00:36:54,070
+تريد أن تسأل شيء؟ لا؟ بعضare called business
+
+501
+00:36:54,070 --> 00:36:59,050
+person he can be businessman or business woman and
+
+502
+00:36:59,050 --> 00:37:13,310
+he can be defined as as what one anyone
+
+503
+00:37:13,310 --> 00:37:17,330
+is
+
+504
+00:37:17,330 --> 00:37:21,150
+employed at usually profit oriented profit
+
+505
+00:37:21,150 --> 00:37:24,080
+orientedentrepreneur anyone involved in a
+
+506
+00:37:24,080 --> 00:37:27,520
+management senior level in a company it can be
+
+507
+00:37:27,520 --> 00:37:31,320
+called businessman or business woman that's for
+
+508
+00:37:31,320 --> 00:37:38,560
+principal the next is an agent agent I mean this
+
+509
+00:37:38,560 --> 00:37:41,460
+slide as you can see it here look at it most
+
+510
+00:37:41,460 --> 00:37:43,260
+likely going to have some questions in the exam
+
+511
+00:37:44,080 --> 00:37:48,060
+about the agent who is an agent how many types of
+
+512
+00:37:48,060 --> 00:37:52,340
+agents because this link this agency is concerned
+
+513
+00:37:52,340 --> 00:37:56,800
+and focused on agent because he or she will make
+
+514
+00:37:56,800 --> 00:37:59,740
+the main job the main business is done by the
+
+515
+00:37:59,740 --> 00:38:04,360
+agent okay we will look at how many types agent is
+
+516
+00:38:04,360 --> 00:38:10,240
+agent is a person like an agent like a like a
+
+517
+00:38:10,240 --> 00:38:16,820
+principal is a person but this person hereماذا
+
+518
+00:38:16,820 --> 00:38:21,380
+يفعل؟ انظر إلى الاسم اللي لدينا .. انظر لدينا
+
+519
+00:38:21,380 --> 00:38:25,480
+اثنين اصالات واحدة منهم للمصادر والثانية للموظف
+
+520
+00:38:25,480 --> 00:38:30,720
+نفس الاسم نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه
+
+521
+00:38:30,720 --> 00:38:30,720
+نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه
+
+522
+00:38:30,720 --> 00:38:30,880
+نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه
+
+523
+00:38:30,880 --> 00:38:31,740
+نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه
+
+524
+00:38:31,740 --> 00:38:33,920
+نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه
+
+525
+00:38:33,920 --> 00:38:35,880
+نفسه
+
+526
+00:38:44,190 --> 00:38:48,050
+هذا حسنًا، إنه يعمل على محافظة الرئيس، مجرد مجرد
+
+527
+00:38:48,050 --> 00:38:52,750
+شخص يستحق أن يعمل على محافظة الرئيس لإنشاء وإنشاء
+
+528
+00:38:52,750 --> 00:38:57,670
+علاقات صحيحة مع الشركة الثالثة لدينا طبعين من مجرد
+
+529
+00:38:57,670 --> 00:39:00,570
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+530
+00:39:00,570 --> 00:39:02,530
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+531
+00:39:02,530 --> 00:39:11,150
+مجرد مجرد مجرد مجرد
+
+532
+00:39:13,370 --> 00:39:18,810
+انت مصطلح وانت مصطلح وانت مصطلح وانت مصطلح وانت
+
+533
+00:39:18,810 --> 00:39:19,510
+مصطلح وانت مصطلح وانت مصطلح وانت مصطلح وانت مصطلح
+
+534
+00:39:19,510 --> 00:39:20,410
+وانت مصطلح وانت مصطلح وانت مصطلح وانت مصطلح وانت
+
+535
+00:39:20,410 --> 00:39:21,470
+مصطلح وانت مصطلح وانت مصطلح وانت مصطلح وانت مصطلح
+
+536
+00:39:21,470 --> 00:39:22,090
+وانت مصطلح وانت مصطلح وانت مصطلح وانت مصطلح وانت
+
+537
+00:39:22,090 --> 00:39:24,350
+مصطلح وانت مصطلح وانت مصطلح وانت مصطلح وانت مصطلح
+
+538
+00:39:24,350 --> 00:39:30,110
+وانت
+
+539
+00:39:30,110 --> 00:39:41,790
+مصطلح و
+
+540
+00:39:43,260 --> 00:39:47,960
+universal how does it sound for you global on a
+
+541
+00:39:47,960 --> 00:39:53,340
+global scale okay anyone else how does it sound
+
+542
+00:39:53,340 --> 00:39:58,740
+that saying universal agent no it's not global yes
+
+543
+00:39:58,740 --> 00:40:03,440
+it sounds like global but it's not I understood it
+
+544
+00:40:03,440 --> 00:40:06,340
+in my way as if someone who works for many
+
+545
+00:40:06,340 --> 00:40:11,590
+companies doing many transactions andOkay someone
+
+546
+00:40:11,590 --> 00:40:20,190
+having a broad authority look at here someone
+
+547
+00:40:20,190 --> 00:40:24,870
+having a broad authority like for example we have
+
+548
+00:40:24,870 --> 00:40:27,650
+here two examples number one is power of attorney
+
+549
+00:40:27,650 --> 00:40:33,790
+the power power of attorney سلطة someone is acting
+
+550
+00:40:33,790 --> 00:40:38,670
+on your behalf acting in your money if you would
+
+551
+00:40:38,670 --> 00:40:44,480
+like to trust somebodyممكن تختار شخص يعرفه جيد
+
+552
+00:40:44,480 --> 00:40:48,620
+جدًا، ممكن تثق به جيدًا، ممكن تثق به جيدًا، ممكن
+
+553
+00:40:48,620 --> 00:40:51,380
+تثق به جيدًا، ممكن تثق به جيدًا، ممكن تثق به
+
+554
+00:40:51,380 --> 00:40:51,980
+جيدًا، ممكن تثق به جيدًا، ممكن تثق به جيدًا، ممكن
+
+555
+00:40:51,980 --> 00:40:52,020
+تثق به جيدًا، ممكن تثق به جيدًا، ممكن تثق به
+
+556
+00:40:52,020 --> 00:40:52,380
+جيدًا، ممكن تثق به جيدًا، ممكن تثق به جيدًا، ممكن
+
+557
+00:40:52,380 --> 00:40:54,220
+تثق به جيدًا، ممكن تثق به جيدًا، ممكن تثق به
+
+558
+00:40:54,220 --> 00:41:01,260
+جيدًا، ممكن تثق به جيدًا، ممكن
+
+559
+00:41:01,260 --> 00:41:10,880
+تثق به جيدًا، ممكن تثق به جيدًا، ممكن تثق به جيد
+
+560
+00:41:13,500 --> 00:41:18,740
+concerning financial affairs and health personal
+
+561
+00:41:18,740 --> 00:41:23,080
+welfare when you trust someone in your money when
+
+562
+00:41:23,080 --> 00:41:26,600
+you trust somebody about your life it must be
+
+563
+00:41:26,600 --> 00:41:30,200
+someone you know for a long time someone you have
+
+564
+00:41:30,200 --> 00:41:36,200
+a confidence with then this is what we call
+
+565
+00:41:36,200 --> 00:41:40,060
+universal agent he or she will have a full
+
+566
+00:41:40,060 --> 00:41:45,850
+authority full authority part agencyهذا الشخص
+
+567
+00:41:45,850 --> 00:41:49,390
+كمجلس عالمي يستطيع أن يتعامل باستخدام المال الخاص
+
+568
+00:41:49,390 --> 00:41:54,510
+بك ونعرف أن أكثر أسعار الأشياء للإنسان هي حياته
+
+569
+00:41:54,510 --> 00:41:58,350
+وماله أليس كذلك؟ حياة ومال
+
+570
+00:42:05,760 --> 00:42:09,820
+وهو ما نسميه الـ universal agent مرة أخرى مثلًا،
+
+571
+00:42:09,820 --> 00:42:16,200
+علاقات مشروعية بين مستخدم ومستخدم، مستخدم في
+
+572
+00:42:16,200 --> 00:42:19,020
+الولايات المتحدة، كانوا يسمونهم مستخدمين أو
+
+573
+00:42:19,020 --> 00:42:22,660
+باريسترين في ال USA، هو يسمونه أو هي يسمونه
+
+574
+00:42:22,660 --> 00:42:29,800
+مستخدم، مستخدم هو شخص يمكننا أن نثق به أو هي لا
+
+575
+00:42:29,800 --> 00:42:36,210
+يجب أن تظهر أسلوب، يجب أن يبقوا أسلوبيجب ان يبحث
+
+576
+00:42:36,210 --> 00:42:40,170
+عنك كشخص
+
+577
+00:42:40,170 --> 00:42:44,190
+يثق بك .. شخص يستطيع حفظ حياتك في الحكم .. شخص
+
+578
+00:42:44,190 --> 00:42:48,650
+يستطيع حفظ مالك .. هذا ما نسميه مجلس عالمي .. هذا
+
+579
+00:42:48,650 --> 00:42:59,230
+رقم 1 رقم 2 مجلس عامل .. ماذا تفعل؟ مجلس عامل؟ هل
+
+580
+00:42:59,230 --> 00:43:03,350
+احد يريد أن يدخل و يقول شيء؟ امل
+
+581
+00:43:07,000 --> 00:43:12,320
+طبعا ان هو اذا كان لديه قوة محددة و ليس قوة مهمة
+
+582
+00:43:12,320 --> 00:43:17,960
+فهو مستخدم محدد فهو
+
+583
+00:43:17,960 --> 00:43:20,020
+مستخدم محدد فهو مستخدم محدد فهو مستخدم محدد فهو
+
+584
+00:43:20,020 --> 00:43:20,100
+مستخدم محدد فهو مستخدم محدد فهو مستخدم محدد فهو
+
+585
+00:43:20,100 --> 00:43:20,120
+مستخدم محدد فهو مستخدم محدد فهو مستخدم محدد فهو
+
+586
+00:43:20,120 --> 00:43:20,120
+مستخدم محدد فهو مستخدم محدد فهو مستخدم محدد فهو
+
+587
+00:43:20,120 --> 00:43:20,140
+مستخدم محدد فهو مستخدم محدد فهو مستخدم محدد فهو
+
+588
+00:43:20,140 --> 00:43:25,320
+مستخدم محدد فهو مستخدم محدد فهو مستخدم
+
+589
+00:43:25,320 --> 00:43:33,240
+محدد فهو
+
+590
+00:43:33,240 --> 00:43:39,680
+مستخدمهنا بعض التعاملات خلال فترة مستمرة من الوقت
+
+591
+00:43:39,680 --> 00:43:47,920
+فترة مستمرة من الوقت قد تكون مثل اعطاء شخص ما بعض
+
+592
+00:43:47,920 --> 00:43:52,640
+الأشياء لتسليمها مني شيء لأفعله مني ولكن هذه أو
+
+593
+00:43:52,640 --> 00:43:57,840
+هذه الأشياء التي اعطيتها لك كمستخدم لي انا لا اقوم
+
+594
+00:43:57,840 --> 00:44:04,600
+بتحطم الوقت اعطيك هذه الأشياء لتسليمها من حياتي و
+
+595
+00:44:04,600 --> 00:44:11,400
+ستكون الوقت مفتوحسنة مستمرة و نحن
+
+596
+00:44:11,400 --> 00:44:13,440
+لدينا الوظيفة الخاصة إذا كنت تنظر إلى الوظيفة
+
+597
+00:44:13,440 --> 00:44:17,260
+الخاصة هنا هناك شيء مشابه للوظيفة العامة و وظيفة
+
+598
+00:44:17,260 --> 00:44:23,340
+خاصة إما لديها تجارب واحدة فقط تجارب واحدة تجارب
+
+599
+00:44:23,340 --> 00:44:24,300
+واحدة تجارب واحدة تجارب واحدة تجارب واحدة تجارب
+
+600
+00:44:24,300 --> 00:44:25,020
+واحدة تجارب واحدة تجارب واحدة تجارب واحدة تجارب
+
+601
+00:44:25,020 --> 00:44:25,160
+واحدة تجارب واحدة تجارب واحدة تجارب واحدة تجارب
+
+602
+00:44:25,160 --> 00:44:25,820
+واحدة تجارب واحدة تجارب واحدة تجارب واحدة تجارب
+
+603
+00:44:25,820 --> 00:44:30,220
+واحدة تجارب واحدة تجارب واحدة تجارب واحدة
+
+604
+00:44:32,260 --> 00:44:37,740
+on my behalf to get a container of commodities
+
+605
+00:44:37,740 --> 00:44:42,260
+specific one transaction one single transaction or
+
+606
+00:44:42,260 --> 00:44:46,500
+it might be here series of transactions more than
+
+607
+00:44:46,500 --> 00:44:50,400
+one transaction series of transactions over a
+
+608
+00:44:50,400 --> 00:44:54,080
+limited period of time within one month within six
+
+609
+00:44:54,080 --> 00:44:58,900
+months within one year a limited period of time so
+
+610
+00:44:58,900 --> 00:45:02,770
+that's what we call special agentهذا كل شيء يتعلق
+
+611
+00:45:02,770 --> 00:45:09,050
+على كم قوة و قوة ستكون لديك هل هو واضح؟ هل انت
+
+612
+00:45:09,050 --> 00:45:15,390
+متأكد؟ اتسأل؟ عميل الوظيفة الوظيفة الوظيفة ستكون
+
+613
+00:45:15,390 --> 00:45:20,370
+لديها سلسلة من التعاملات تسوي أكتر من شيء، تفعل
+
+614
+00:45:20,370 --> 00:45:25,650
+أكتر من مقاومة واحدة، وليس لديها مقاومة في وقت
+
+615
+00:45:25,650 --> 00:45:29,160
+محددهو موقف مفتوح يمكنك أن تفعله في أي موقف تريده
+
+616
+00:45:29,160 --> 00:45:32,740
+في عام واحد او اثنين حتى يحدث شيء يتعامل معه عندما
+
+617
+00:45:32,740 --> 00:45:34,000
+يتعامل معه عندما يتعامل معه عندما يتعامل معه عندما
+
+618
+00:45:34,000 --> 00:45:35,060
+يتعامل معه عندما يتعامل معه عندما يتعامل معه عندما
+
+619
+00:45:35,060 --> 00:45:35,860
+يتعامل معه عندما يتعامل معه عندما يتعامل معه عندما
+
+620
+00:45:35,860 --> 00:45:37,460
+يتعامل معه عندما يتعامل معه عندما يتعامل معه عندما
+
+621
+00:45:37,460 --> 00:45:37,520
+يتعامل معه عندما يتعامل معه عندما يتعامل معه عندما
+
+622
+00:45:37,520 --> 00:45:38,140
+يتعامل معه عندما يتعامل معه عندما يتعامل معه عندما
+
+623
+00:45:38,140 --> 00:45:48,200
+يتعامل معه عند
+
+624
+00:45:57,360 --> 00:46:01,640
+انظر الى قوة الشركة
+
+625
+00:46:01,640 --> 00:46:07,280
+انا اعرف انه يمكن ان يكون كثير من المعلومات اللي
+
+626
+00:46:07,280 --> 00:46:14,440
+عليك انتقلها اليوم ولكنها ليست سهلة انتقلها بسهولة
+
+627
+00:46:14,440 --> 00:46:18,540
+انا اعرف ان الحلقه الثانيه بسهولة الحلقه الثالثه
+
+628
+00:46:18,540 --> 00:46:22,840
+هي نفس الشيء بسهولة اعرف ان الجزء المصعب في هذا
+
+629
+00:46:22,840 --> 00:46:27,260
+الموضوع هوUnderstanding commercially in the
+
+630
+00:46:27,260 --> 00:46:29,500
+beginning it's kind of difficult too much
+
+631
+00:46:29,500 --> 00:46:32,100
+information But now it becomes easy for you to
+
+632
+00:46:32,100 --> 00:46:34,820
+understand now. We will look at the authority look
+
+633
+00:46:34,820 --> 00:46:38,000
+at this Principal gives the authority to the agent
+
+634
+00:46:38,000 --> 00:46:44,240
+او ثورة سلطة my authority Basic to you as my agent
+
+635
+00:46:44,240 --> 00:46:49,660
+How how can we pass this authority from the
+
+636
+00:46:49,660 --> 00:46:53,620
+principal to the agent? And how much authority can
+
+637
+00:46:53,620 --> 00:47:07,930
+I give?the agent yes
+
+638
+00:47:07,930 --> 00:47:11,430
+we
+
+639
+00:47:11,430 --> 00:47:16,210
+can understand that someone has an authority to
+
+640
+00:47:16,210 --> 00:47:23,030
+become an agent by words by conduct explicit or
+
+641
+00:47:23,030 --> 00:47:29,000
+implicitit's implicit and clear we can notice it
+
+642
+00:47:29,000 --> 00:47:32,440
+implicit ضمني which is not clear but we can
+
+643
+00:47:32,440 --> 00:47:37,060
+understand reasonably reasonably we can understand
+
+644
+00:47:37,060 --> 00:47:44,020
+that someone has an agency we can take one to the
+
+645
+00:47:44,020 --> 00:47:48,140
+first one first type we can complete next time the
+
+646
+00:47:48,140 --> 00:47:54,980
+rest of them number oneهنا لدينا ثلاثة أسلوب ثلاثة
+
+647
+00:47:54,980 --> 00:48:01,020
+أسلوب قوات رقم واحد هو القوة الحقيقية القوة
+
+648
+00:48:01,020 --> 00:48:08,460
+الحقيقية رقم اثنان هو القوة الواضحة رقم
+
+649
+00:48:08,460 --> 00:48:16,780
+ثلاثة هو القوة تحت موقعها لنبدأ اليوم برقم واحد
+
+650
+00:48:16,780 --> 00:48:20,760
+أول أسلوب نستطيع أن نكمل المزيد منهم المرة القادمة
+
+651
+00:48:21,620 --> 00:48:25,960
+الرقم واحد هو الوثيقة الحقيقية هذه الوثيقة كما ترى
+
+652
+00:48:25,960 --> 00:48:32,600
+هنا بين مصطلح ومصطلح الذي تم إعطائه المصطلح
+
+653
+00:48:32,600 --> 00:48:40,080
+للمصطلح يمكن أن يكون حقيقي حقيقي حقيقي حقيقي واضح
+
+654
+00:48:40,080 --> 00:48:44,400
+ليس صعب هذه الوثيقة الحقيقية يمكن أن تكون من ثلاث
+
+655
+00:48:44,400 --> 00:48:49,560
+طرح من ثلاث طرح مختلفة رقم واحد يمكن أن يكون واضح
+
+656
+00:48:49,560 --> 00:48:56,640
+واضحعندما أقول لك اروى هي مصطلحي، هي مصطلحي، هذه
+
+657
+00:48:56,640 --> 00:49:00,940
+كلماتي، تستطيع أن تفهمها بشكل بسيط، هي مصطلحي،
+
+658
+00:49:00,940 --> 00:49:07,940
+لذلك هذا ما نسميه كمصطلح حقيقي، مصطلح يعطي مصطلح
+
+659
+00:49:07,940 --> 00:49:14,120
+حقيقي، في هذه الحالة سأكون
+
+660
+00:49:14,120 --> 00:49:18,560
+مخطط كمصطلح لكل مصطلحي
+
+661
+00:49:21,710 --> 00:49:25,830
+as long as my agent was following my instructions
+
+662
+00:49:25,830 --> 00:49:30,730
+even though sometimes I would have to .. I would
+
+663
+00:49:30,730 --> 00:49:34,690
+have to pay him for my agent's mistake I would
+
+664
+00:49:34,690 --> 00:49:38,150
+have to be liable for my agent's mistake like here
+
+665
+00:49:38,150 --> 00:49:45,530
+can you read it for me? this is for the landly
+
+666
+00:49:51,510 --> 00:49:55,990
+even though sometimes the agent is acting
+
+667
+00:49:55,990 --> 00:50:01,450
+fraudulently with deception fraud cheating if the
+
+668
+00:50:01,450 --> 00:50:07,030
+agent was cheating what can I do I will stop him I
+
+669
+00:50:07,030 --> 00:50:12,490
+will I will release him I will fire himhe or she
+
+670
+00:50:12,490 --> 00:50:15,030
+will not be working for me anymore , I will end
+
+671
+00:50:15,030 --> 00:50:18,590
+the contract of agents even like now we have a
+
+672
+00:50:18,590 --> 00:50:23,210
+situation in which my agent was cheating and he
+
+673
+00:50:23,210 --> 00:50:25,590
+made a contract or deal or transaction with
+
+674
+00:50:25,590 --> 00:50:29,670
+somebody am I going to be responsible for this or
+
+675
+00:50:29,670 --> 00:50:33,570
+not my
+
+676
+00:50:33,570 --> 00:50:38,270
+agent
+
+677
+00:50:38,270 --> 00:50:43,870
+was acting through the lanternfraud غش cheating
+
+678
+00:50:43,870 --> 00:50:48,890
+deception will
+
+679
+00:50:48,890 --> 00:50:54,730
+the principal be liable because someone is aware
+
+680
+00:50:54,730 --> 00:50:58,890
+of this and the agent is responsible for this
+
+681
+00:50:58,890 --> 00:51:04,100
+fraudif the customer was not aware of this if the
+
+682
+00:51:04,100 --> 00:51:08,920
+principal responsible and he might .. when he
+
+683
+00:51:08,920 --> 00:51:14,420
+comes he might come at the end this must be
+
+684
+00:51:14,420 --> 00:51:18,900
+monitored and controlled eight months in order but
+
+685
+00:51:18,900 --> 00:51:24,640
+there is no freedom no freedom well we have a
+
+686
+00:51:24,640 --> 00:51:28,380
+situation now it's done there was a mistake there
+
+687
+00:51:28,380 --> 00:51:32,960
+was deception فيه غشthen the principal will be
+
+688
+00:51:32,960 --> 00:51:37,320
+liable both of them in fact principal and agent
+
+689
+00:51:37,320 --> 00:51:41,480
+both will be liable towards the customer we have
+
+690
+00:51:41,480 --> 00:51:44,620
+to be the customer then we can come back at each
+
+691
+00:51:44,620 --> 00:51:47,680
+other يعني بعدين احنا نتفق بيننا even if he was
+
+692
+00:51:47,680 --> 00:51:50,780
+aware even if he .. no no no if he was not aware
+
+693
+00:51:50,780 --> 00:51:54,300
+if the customer was innocent he did not know
+
+694
+00:51:54,300 --> 00:51:58,840
+anything he was acting in good faith he was honest
+
+695
+00:51:59,680 --> 00:52:04,380
+ثم في هذه الحالة يجب أن نموذج المستخدم وكل شيء
+
+696
+00:52:04,380 --> 00:52:09,560
+سيكون على ما يرام منه، ثم كاميرا ومصطلح سيعودوا مع
+
+697
+00:52:09,560 --> 00:52:15,300
+بعضهم البعض، إذا كان مصطلحي يجعلني أحرق، سأعود
+
+698
+00:52:15,300 --> 00:52:20,460
+إليه، سأخذ المال منه، سيموذجني، لكن أولا يجب أن
+
+699
+00:52:20,460 --> 00:52:24,840
+نموذج المستخدم، ثم في هذه الحالة يمكننا أن نقول،
+
+700
+00:52:24,840 --> 00:52:30,350
+حتى لو كان مصطلحي يعمل بإيمان سيئ،والتخلص لـ
+
+701
+00:52:30,350 --> 00:52:36,410
+Lendly فسأكون مسئول لأنه مصطلحي لأي حالة انا سأحمي
+
+702
+00:52:36,410 --> 00:52:42,170
+مصطلحي و انا و بعدها انا استطيع ان اعود لمصطلحي و
+
+703
+00:52:42,170 --> 00:52:47,810
+اطلب منه تجارب جيد؟ هذا رقم واحد رقم اثنان أحيانا
+
+704
+00:52:47,810 --> 00:52:51,710
+لا يوجد اتفاق مثل هنا لدينا اتفاق بين مصطلح و
+
+705
+00:52:51,710 --> 00:52:54,910
+مصطلح هنا ليس لدينا اتفاق
+
+706
+00:52:58,650 --> 00:53:03,790
+وحتى .. يعني مثلًا .. لا يوجد اتفاق ..فش اتفاق ..
+
+707
+00:53:03,790 --> 00:53:06,970
+فش اتفاق .. لا يوجد اتفاق .. لكن كلمات الاصطناع أو
+
+708
+00:53:06,970 --> 00:53:11,670
+الاتفاق بشكل عقل لدى الجمهور الثالث ليؤمن ان
+
+709
+00:53:11,670 --> 00:53:16,230
+الوظيفة كانت تعمل على محافظة الاصطناع انا لم اشتر
+
+710
+00:53:16,230 --> 00:53:21,530
+اتفاق مع .. لا .. لا يوجد اتفاق مع وظيفتي .. لا
+
+711
+00:53:21,530 --> 00:53:29,150
+اتفاق .. لكن اتفاقتيlook at the conduct my conduct
+
+712
+00:53:29,150 --> 00:53:34,670
+reasonably بشكل معقول led you the customers to
+
+713
+00:53:34,670 --> 00:53:40,390
+believe that she is my agent in this case she is
+
+714
+00:53:40,390 --> 00:53:44,030
+what she's acting here what she's doing here she's
+
+715
+00:53:44,030 --> 00:53:46,450
+acting on my behalf I will be responsible for the
+
+716
+00:53:46,450 --> 00:53:50,530
+action because I give the impression like we'll
+
+717
+00:53:50,530 --> 00:53:51,350
+see later on here
+
+718
+00:53:54,500 --> 00:53:56,980
+I give the impression next time next slide we
+
+719
+00:53:56,980 --> 00:53:59,360
+gonna see it sometime I give the impression but in
+
+720
+00:53:59,360 --> 00:54:03,260
+this case it's not only impression conduct حركة it
+
+721
+00:54:03,260 --> 00:54:06,100
+doesn't have to be by words it's implicit here
+
+722
+00:54:06,100 --> 00:54:12,120
+implicit ضمنها implied I implied that she is my
+
+723
+00:54:12,120 --> 00:54:19,220
+agent then third parties customers believe that
+
+724
+00:54:19,220 --> 00:54:21,680
+she was my agent then in this case what she was
+
+725
+00:54:21,680 --> 00:54:26,910
+doingwill bind me will bind me like for example I
+
+726
+00:54:26,910 --> 00:54:31,950
+know that you are waiting to listen and to have
+
+727
+00:54:31,950 --> 00:54:36,210
+more information about this point for example when
+
+728
+00:54:36,210 --> 00:54:38,830
+I stand in my business and I have sometimes you
+
+729
+00:54:38,830 --> 00:54:42,750
+know in the business you have many sectors and in
+
+730
+00:54:42,750 --> 00:54:47,010
+each sector I have an agent in each sector I would
+
+731
+00:54:47,010 --> 00:54:49,250
+have an agent and I appoint
+
+732
+00:54:52,330 --> 00:54:57,290
+she is specialist in makeup she will be my agent
+
+733
+00:54:57,290 --> 00:55:01,170
+she is working in this sector only and alaa is
+
+734
+00:55:01,170 --> 00:55:07,510
+working in electronics here now
+
+735
+00:55:07,510 --> 00:55:12,210
+for some reason samiha today was not here she was
+
+736
+00:55:12,210 --> 00:55:16,710
+not she was away she was off sick she was going
+
+737
+00:55:16,710 --> 00:55:20,030
+out to do something for me anyway i asked on front
+
+738
+00:55:20,030 --> 00:55:23,100
+of you there i asked alaato take care of the
+
+739
+00:55:23,100 --> 00:55:27,100
+customers here this kind of indication that she
+
+740
+00:55:27,100 --> 00:55:29,840
+can take care of the customer it means she can
+
+741
+00:55:29,840 --> 00:55:33,280
+sell on my behalf she can act here despite the
+
+742
+00:55:33,280 --> 00:55:36,620
+fact she's my agent only in this section in this
+
+743
+00:55:36,620 --> 00:55:39,380
+sector but I gave the indication and you
+
+744
+00:55:39,380 --> 00:55:42,980
+understood from my conduct that well she can act
+
+745
+00:55:42,980 --> 00:55:47,900
+she can work she can make decisions in this way in
+
+746
+00:55:47,900 --> 00:55:52,400
+this sector and then signing contracts with youهذا
+
+747
+00:55:52,400 --> 00:55:58,420
+ما نسميه هنا بيكندكت بسهولة واضحة امبلسية اوثورد
+
+748
+00:55:58,420 --> 00:56:04,020
+رقم ثلاثة هذا نوع من الموضوع المهم ان تنظر و تقرأه
+
+749
+00:56:04,020 --> 00:56:10,220
+احدهم سميها if what the agent proposes to do it
+
+750
+00:56:10,220 --> 00:56:15,320
+reasonably necessary to accomplish and actually
+
+751
+00:56:15,320 --> 00:56:19,460
+obtain copyright transaction then the principal
+
+752
+00:56:19,460 --> 00:56:24,240
+will be a bondOkay if the agent what he was doing
+
+753
+00:56:24,240 --> 00:56:28,520
+if what the agent was proposed to do was necessary
+
+754
+00:56:28,520 --> 00:56:32,100
+to complete the main transaction if I was an agent
+
+755
+00:56:32,100 --> 00:56:35,600
+my principal asked me to do something on his
+
+756
+00:56:35,600 --> 00:56:39,940
+behalf everything like going to china to get
+
+757
+00:56:39,940 --> 00:56:46,480
+commodities get container of what
+
+758
+00:56:46,480 --> 00:56:48,800
+do you want to buy from china
+
+759
+00:56:52,300 --> 00:56:57,060
+أو ميكاب ربما. عندما ذهبت هناك لصينيا لشرح ميكاب
+
+760
+00:56:57,060 --> 00:57:04,240
+كنتين أو ميكاب و أحضرته لفلسطين، فمعرفتي أعطاني كل
+
+761
+00:57:04,240 --> 00:57:08,520
+المعلومات، ماذا يجب أن تفعل؟ و كم يجب أن تكون؟ و
+
+762
+00:57:08,520 --> 00:57:13,280
+كم يجب أن تحصل؟ كل شيء، لكن بعد ذلك وجدت أن هناك
+
+763
+00:57:13,280 --> 00:57:17,960
+شيء مهم يجب أن أفعله، لكنه لم يخبرني عنه، شيء كان
+
+764
+00:57:17,960 --> 00:57:22,450
+محتاجًابعض المرحلات اللي علي اختيارها هي المرحلات
+
+765
+00:57:22,450 --> 00:57:29,370
+القانونية كيف اشبه مجتمعين من شنقه بباليستان اللي
+
+766
+00:57:29,370 --> 00:57:33,770
+يحتاجون لبعض المال على بعض الاختصارات انا سوف احصل
+
+767
+00:57:33,770 --> 00:57:43,430
+عرض مع اي شخص مثلا عاملين اعمال مجلسي يساعدوني في
+
+768
+00:57:43,430 --> 00:57:48,080
+اختيار اتفاق مثل هذاإذا كان هناك شيء لم أكن أخبره
+
+769
+00:57:48,080 --> 00:57:53,300
+عنه، فسأجب أن أفعله، لأن عندما أشعر أن ما يجب أن
+
+770
+00:57:53,300 --> 00:57:58,460
+أفعله كخطوة قانونية يجب أن يكمل التجارب الأساسية
+
+771
+00:57:58,460 --> 00:58:03,480
+التي كان من المفترض أن أفعلها، فما كنت أفعله سيكون
+
+772
+00:58:03,480 --> 00:58:09,780
+قانوني، ويجب أن يكون قانوني قانوني قانوني قانوني
+
+773
+00:58:09,780 --> 00:58:14,900
+قانوني قانوني قانوني قانوني قانوني قانوني قانوني
+
+774
+00:58:14,900 --> 00:58:15,020
+قانوني قانوني قانوني قانوني قانوني قانوني قانوني
+
+775
+00:58:15,020 --> 00:58:15,040
+قانوني قانوني قانوني قانوني قانوني قانوني قانوني
+
+776
+00:58:15,040 --> 00:58:18,070
+قانوني قانوني قانوني قانوني قانanother example
+
+777
+00:58:18,070 --> 00:58:21,990
+okay like it's not a commercial law it's civil law
+
+778
+00:58:21,990 --> 00:58:28,170
+asking our she's a contractor and engineer asking
+
+779
+00:58:28,170 --> 00:58:31,270
+her see look at this hall how beautiful is it nice
+
+780
+00:58:31,270 --> 00:58:35,910
+look we have curtains air conditioners light fans
+
+781
+00:58:35,910 --> 00:58:40,990
+mic speakers LCD's computer chairs students
+
+782
+00:58:40,990 --> 00:58:47,350
+cameras all these equipments for the hallIf I as a
+
+783
+00:58:47,350 --> 00:58:52,310
+principal and I have my agent and I ask her to ..
+
+784
+00:58:52,310 --> 00:58:55,530
+to make this room really as a studio so we can
+
+785
+00:58:55,530 --> 00:58:59,050
+record all what we have here and I pay her the
+
+786
+00:58:59,050 --> 00:59:03,270
+money and I ask her to buy everything in the
+
+787
+00:59:03,270 --> 00:59:08,210
+contract between me and her including everything
+
+788
+00:59:08,210 --> 00:59:15,200
+but we forgot to mention the curtainsلكن كانت هنا
+
+789
+00:59:15,200 --> 00:59:19,460
+تفعل كل شيء جاهز في هذا الغرفة في هذا الستوديو
+
+790
+00:59:19,460 --> 00:59:24,080
+لكنها وجدت أن هذا الستوديو لن يكون استوديو جيد
+
+791
+00:59:24,080 --> 00:59:28,380
+بدون الكرتين لأننا سنحصل على ضوء من الويندوز و هذا
+
+792
+00:59:28,380 --> 00:59:32,400
+الضوء سيتفرج بشكل سيئ على الكاميرات و بعد ذلك
+
+793
+00:59:32,400 --> 00:59:39,260
+اشترتهم لتكمل هذه التجارة انها تجارة عامة و بسيطة
+
+794
+00:59:39,260 --> 00:59:42,620
+و حتى لو كانت تجارة مجتمعيةit's a commercial or
+
+795
+00:59:42,620 --> 00:59:44,440
+civil transaction it doesn't make any difference
+
+796
+00:59:44,440 --> 00:59:47,260
+in this point I'm trying just to explain it now
+
+797
+00:59:47,260 --> 00:59:50,520
+what she was doing here was something necessary to
+
+798
+00:59:50,520 --> 00:59:55,200
+complete what we supposed to to do another example
+
+799
+00:59:55,200 --> 01:00:02,400
+another example an agent was feeling that this
+
+800
+01:00:02,400 --> 01:00:04,600
+business will not be successful without
+
+801
+01:00:04,600 --> 01:00:10,280
+advertisementsأعطيت عملتي هنا في هذا البلد لأحد
+
+802
+01:00:10,280 --> 01:00:14,120
+أصدقائي و هو شركتي و ذهبت إلى الولايات المتحدة
+
+803
+01:00:14,120 --> 01:00:20,480
+لسنة لعملية أخرى و شركتي كانت تشعر أن عملية أن
+
+804
+01:00:20,480 --> 01:00:24,060
+تكون ناجحة يجب أن تكون إعلانا في مجلس رسالة على
+
+805
+01:00:24,060 --> 01:00:29,740
+التلفاز لكنني لم أعطر هذه التعاملات لم أطلب منه أن
+
+806
+01:00:29,740 --> 01:00:34,970
+يفعلها فما كان يقترح أن يفعله كان يأخذ المرحلةwas
+
+807
+01:00:34,970 --> 01:00:37,330
+necessary to complete the business to be
+
+808
+01:00:37,330 --> 01:00:41,910
+successful this business then what he did he made
+
+809
+01:00:41,910 --> 01:00:44,170
+an advertisement in a newspaper and he paid for
+
+810
+01:00:44,170 --> 01:00:48,950
+that when I come back I would be liable I would I
+
+811
+01:00:48,950 --> 01:00:52,650
+would say yes I cannot say no to that I would have
+
+812
+01:00:52,650 --> 01:00:55,710
+to pay for it because all the steps have been
+
+813
+01:00:55,710 --> 01:00:58,530
+taken by my agents were necessary to complete the
+
+814
+01:00:58,530 --> 01:01:01,230
+transactions it's not something extra it's
+
+815
+01:01:01,230 --> 01:01:05,790
+something was necessary for the transactionTime is
+
+816
+01:01:05,790 --> 01:01:08,290
+passing so quickly well thank you very much for
+
+817
+01:01:08,290 --> 01:01:12,130
+your time and I will see you next week
+
diff --git a/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/-4choVeOJ-U_raw.json b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/-4choVeOJ-U_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..57200f1a897987bf2288169383ec41f800c5a179
--- /dev/null
+++ b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/-4choVeOJ-U_raw.json
@@ -0,0 +1 @@
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2043.13, "end": 2043.83, "word": " القادمة", "probability": 0.98974609375}, {"start": 2043.83, "end": 2044.61, "word": " نتحدث", "probability": 0.9610595703125}, {"start": 2044.61, "end": 2044.89, "word": " عن", "probability": 0.98583984375}, {"start": 2044.89, "end": 2045.41, "word": " ما", "probability": 0.86572265625}, {"start": 2045.41, "end": 2046.09, "word": " تبقى", "probability": 0.9906005859375}, {"start": 2046.09, "end": 2046.39, "word": " من", "probability": 0.98681640625}, {"start": 2046.39, "end": 2047.47, "word": " موضوعات", "probability": 0.9931640625}, {"start": 2047.47, "end": 2048.17, "word": " ومفردات", "probability": 0.94775390625}, {"start": 2048.17, "end": 2048.65, "word": " خيار", "probability": 0.9930013020833334}, {"start": 2048.65, "end": 2049.15, "word": " العيب", "probability": 0.9920247395833334}, {"start": 2049.15, "end": 2049.47, "word": " أقول", "probability": 0.901611328125}, {"start": 2049.47, "end": 2049.85, "word": " قولي", "probability": 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محمد", "probability": 0.9894205729166666}, {"start": 2055.11, "end": 2055.97, "word": " والسلام", "probability": 0.9298502604166666}, {"start": 2055.97, "end": 2056.43, "word": " عليكم", "probability": 0.948486328125}, {"start": 2056.43, "end": 2056.81, "word": " ورحمة", "probability": 0.985595703125}, {"start": 2056.81, "end": 2056.99, "word": " الله", "probability": 0.9638671875}, {"start": 2056.99, "end": 2058.25, "word": " وبركاته", "probability": 0.92548828125}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2058.541875, "duration_after_vad": 1994.693749999997}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/1bbhS5gDkkM_postprocess.srt b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/1bbhS5gDkkM_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..1dcb0d1153f4894f94b8e8d1ffbf320dd235389f
--- /dev/null
+++ b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/1bbhS5gDkkM_postprocess.srt
@@ -0,0 +1,1228 @@
+1
+00:00:05,260 --> 00:00:08,120
+أعوذ بالله السميع لعليمنا الشيطان الراجيم باسم
+
+2
+00:00:08,120 --> 00:00:11,460
+الله الرحمن الرحيم الحمد لله رب العالمين والصلاة
+
+3
+00:00:11,460 --> 00:00:15,680
+والسلام على أشرف الأنبياء والمرسلين سيدنا محمد بن
+
+4
+00:00:15,680 --> 00:00:19,580
+عبدالله الصادق الأمين ثم أما بعد أحيكم جميعا بتحية
+
+5
+00:00:19,580 --> 00:00:24,420
+الإسلام فالسلام عليكم ورحمة الله تعالى وبركاته كيف
+
+6
+00:00:24,420 --> 00:00:28,560
+حالكوا نطيبات ان شاء الله تحضرنا جيد ان شاء الله
+
+7
+00:00:28,560 --> 00:00:30,620
+اذا
+
+8
+00:00:31,890 --> 00:00:36,710
+كنا قد تحدثنا المحاضرة السابقة عن عقد السلام
+
+9
+00:00:36,710 --> 00:00:42,370
+وعرفنا أن عقد السلام يعد مستثنى من بيع المعدوم ذلك
+
+10
+00:00:42,370 --> 00:00:45,810
+أن الأصل فيه أنه غير جائز لأن المعقود عليه في
+
+11
+00:00:45,810 --> 00:00:48,950
+البيع يجب أن يكون موجودا فكونه غير معدوم إذا لا
+
+12
+00:00:48,950 --> 00:00:54,330
+يجوز لكن السلام استثنية من بيع المعدوم للحاجة فقد
+
+13
+00:00:54,330 --> 00:00:58,510
+ثبت أن النبي صلى الله عليه وسلم قدم إلى المدينة
+
+14
+00:00:58,510 --> 00:01:02,780
+والناس يسلفون في التمر السنتين والثلاثفقال صلى
+
+15
+00:01:02,780 --> 00:01:08,540
+الله عليه وسلم من أسلف في شيء ففي كيل معلوم ووزن
+
+16
+00:01:08,540 --> 00:01:14,560
+معلوم إلى أجل معلوم فتحدثنا عن مشروعيته ثم انتقلنا
+
+17
+00:01:14,560 --> 00:01:20,160
+للحديث عن أركانه وقلنا إن أركان بيع السلم تماما
+
+18
+00:01:20,160 --> 00:01:24,400
+كأركان البيع باعتبار أن السلم يعد بيعا من البيوع
+
+19
+00:01:24,400 --> 00:01:31,400
+لكن وفق آلية محددةفلابد فيه من الصيغة و العاقدان و
+
+20
+00:01:31,400 --> 00:01:38,880
+المعقود عليه بالنسبة لصيغة السلام مثلها مثل البيع
+
+21
+00:01:38,880 --> 00:01:43,480
+في ثلاثة شروط لأنه في البيع قلنا لابد من الاتصال
+
+22
+00:01:43,480 --> 00:01:47,280
+بين الإيجاب و القبول و لابد من الموافقة بينهما و
+
+23
+00:01:47,280 --> 00:01:53,510
+لابد أن تكون ناجزة يضافوا إلى هذه الشروطشروط خاصة
+
+24
+00:01:53,510 --> 00:01:58,650
+بصيغة السلام وهي أن تكون الصيغة بلفظ السلمي أو
+
+25
+00:01:58,650 --> 00:02:03,890
+السلف وأن تكون الصيغة خالية عن خيار الشرط وتحدثنا
+
+26
+00:02:03,890 --> 00:02:08,870
+عن ذلك تفصيلا المحاضرة السابقة أيضا تحدثنا عن
+
+27
+00:02:08,870 --> 00:02:14,150
+الركن الثاني من أركان عقد السلم اللى هو العاقدين
+
+28
+00:02:14,150 --> 00:02:19,220
+المسلم والمسلم إليهحتى يصح عقد السلام تحدثنا أنه
+
+29
+00:02:19,220 --> 00:02:23,620
+لابد في كل من المسلم والمسلم إليه خمسة شروط وهي
+
+30
+00:02:23,620 --> 00:02:28,240
+ذات الشروط التي تشترط في عقدي البيع باستثناء شرط
+
+31
+00:02:28,240 --> 00:02:35,220
+البصر فقد ثبت عن الشافعية أنهم لا يجيزون بيع ولا
+
+32
+00:02:35,220 --> 00:02:40,640
+شراء الأعمى لكنهم أجازوا السلم منه أما بالنسبة
+
+33
+00:02:40,640 --> 00:02:46,470
+للرقم الثالث والذي تحدثنا فيه عن رأس مالالسلم
+
+34
+00:02:46,470 --> 00:02:51,290
+المعقود عليه عندنا رأس مال و عندنا مسلم فيه فرأس
+
+35
+00:02:51,290 --> 00:02:57,590
+المال أي الثمن فلابد في الثمن أن يكون معلوما ببيان
+
+36
+00:02:57,590 --> 00:03:03,350
+جنسه ونوعه وصفته وقدره وأيضا يجب أن يسلم في مجلس
+
+37
+00:03:03,350 --> 00:03:10,590
+العقدتسليما حقيقيا وأن يُقبض فلا يجوز أن يكون
+
+38
+00:03:10,590 --> 00:03:15,590
+القبض غير حقيقي كالحوالة وغير ذلك على ما فصلناه
+
+39
+00:03:15,590 --> 00:03:20,570
+سابقا اليوم بإذن الله سنشرع بالحديث عن شروط المسلم
+
+40
+00:03:20,570 --> 00:03:25,950
+فيه وقولنا إن عقد السلام أصلا هو بيع موصوف في
+
+41
+00:03:25,950 --> 00:03:30,900
+الذمةفكون السلام معدوم إذا يجب أن يكون موصوفا في
+
+42
+00:03:30,900 --> 00:03:37,340
+الذمة حتى يقوم الوصف مقام الرؤية لذلك أول شرط من
+
+43
+00:03:37,340 --> 00:03:43,200
+هذه الشروط أنه يجب أن يكون مما يمكن ضبط صفاته
+
+44
+00:03:43,200 --> 00:03:49,210
+بالوصفالتي يختلف الثمن باختلافها لأن كلنا يعلم
+
+45
+00:03:49,210 --> 00:03:55,350
+دائما بأن المبيع ثمنه بيتحدث بناء على أوصافه فكل
+
+46
+00:03:55,350 --> 00:04:00,990
+ما زادت الأوصافزاد السعر وارتفع السعر بينما لو
+
+47
+00:04:00,990 --> 00:04:05,110
+كانت الأوصاف زهيدة وقليلة فبالتأكيد سيتأثر الثمن
+
+48
+00:04:05,110 --> 00:04:11,090
+من هنا كان لابد من أن يكون المسلم فيه مما يمكن ضبط
+
+49
+00:04:11,090 --> 00:04:16,470
+صفاته باعتبار كونه معدوم وبناء على ذلك نقول بأن
+
+50
+00:04:16,470 --> 00:04:21,230
+السلم يصح في جميع المكيلات والموزونات والعدديات
+
+51
+00:04:21,230 --> 00:04:26,430
+والمذروعات كل شئ بينبع بالوزن أو بالكيل أو بالعدد
+
+52
+00:04:26,430 --> 00:04:33,270
+أو بالذراعفيجوزوا بيعه سلامة وبالتالي عادي جدا
+
+53
+00:04:33,270 --> 00:04:37,330
+انبيع الجمح عادي جدا انبيع الدرة عادي جدا انبيع
+
+54
+00:04:37,330 --> 00:04:43,610
+السمسم سلامة يعني عادي جدا انبيع البيضلكن في موضوع
+
+55
+00:04:43,610 --> 00:04:47,290
+البيض كنا بنعرف أنه في بيضة صغيرة و في بيضة كبيرة
+
+56
+00:04:47,290 --> 00:04:52,050
+و في وسط صح فأنا لما بدي أتفج معك على خليني أقول
+
+57
+00:04:52,050 --> 00:04:56,270
+مية كرتونة من البيض مثلا تجيبي ليهم بواحد خمسة أو
+
+58
+00:04:56,270 --> 00:05:02,450
+بواحد ستة فلابد أن نتفق ابتداء على أنه من الحجم
+
+59
+00:05:02,450 --> 00:05:07,300
+الوسط أو الكبير أو الصغيروبعد كده أي خلاف في الحجم
+
+60
+00:05:07,300 --> 00:05:11,020
+الصغير هيكون لا يعتدوا به يعني أنا لما أكون متفجة
+
+61
+00:05:11,020 --> 00:05:15,520
+معاك على ميت كرتونة من البيت حجم صغير طب ما الحجم
+
+62
+00:05:15,520 --> 00:05:19,880
+الصغير متقارب يعني حتى لو كانت تفاوت التفاوت بينه
+
+63
+00:05:19,880 --> 00:05:25,040
+لا يعتدوا به لكن أجي أتفج معاك على ميت كرتونة بيت
+
+64
+00:05:25,040 --> 00:05:28,840
+بدون ما نتفج على حجمه طبعا وقت هيصير في نزاع
+
+65
+00:05:28,840 --> 00:05:33,570
+وبالتالي ما بصح السلاموبالتالي نجي للعدديات في
+
+66
+00:05:33,570 --> 00:05:39,950
+عدديات يعني متقاربة بالحجم كالبيض مثلا فيصحوا فيها
+
+67
+00:05:39,950 --> 00:05:47,310
+السلام وفي عدديات متفاوتة بالحجم فهذه لا يصح بيعها
+
+68
+00:05:47,310 --> 00:05:53,690
+سلاما بالعدد لكن إن أن كان بيعها بالوزن جاز البطيخ
+
+69
+00:05:54,780 --> 00:05:59,520
+أو البطيخ كلغة فصحى هي بطيخ بس إحنا بالعامية بنقول
+
+70
+00:05:59,520 --> 00:06:04,600
+بطيخ فبطيخ أو بطيخ كلاهما بطيخ على أي حال نيجي
+
+71
+00:06:04,600 --> 00:06:12,410
+للبطيخ أو البطيخ كلغة يعني بس مش أكترالان البطيخ
+
+72
+00:06:12,410 --> 00:06:17,570
+يا جماعة، في بطيخة هلجد و في بطيخة هيك، صح؟ تمام
+
+73
+00:06:17,570 --> 00:06:22,010
+فالان في تفاوت بين هذه و هذه، اه بالتأكيد في تفاوت
+
+74
+00:06:22,010 --> 00:06:27,310
+بيناتهم فما بصير اروح اتفج مع سين من الناس على انه
+
+75
+00:06:27,310 --> 00:06:32,690
+يجيبلي قلقه مية بطيخة بتاريخ معينليش؟ لأنه وجد ما
+
+76
+00:06:32,690 --> 00:06:36,310
+يسلمني هيجيب ليهم وسط، أقول له لأ أنا بدي أكبر من
+
+77
+00:06:36,310 --> 00:06:40,350
+هيك، بدي أصغر من هيك، هنسيب نتجاتل، فما بيصير
+
+78
+00:06:40,350 --> 00:06:45,150
+انبيع البطيخ بالعدد لأنه متفاوت، لكن البطيخ اليوم
+
+79
+00:06:45,150 --> 00:06:49,250
+بنبع بالوزن ولا لأ؟ انبع لا بنبع، وبالتالي الوزن
+
+80
+00:06:49,250 --> 00:06:53,810
+يقوم مقام العدد، فعادي جدا أدفق مع المسلم إليه،
+
+81
+00:06:53,810 --> 00:06:58,680
+أقول له مثلا بدي طن من البطيخفبالتالي لما يجيبلي
+
+82
+00:06:58,680 --> 00:07:02,880
+طن انا مش راح اروح اتجتل معاه على انه اكمل بطيخة
+
+83
+00:07:02,880 --> 00:07:06,800
+لأ احنا متفقين على وزن بعيدا عن عدد البطيخات اللي
+
+84
+00:07:06,800 --> 00:07:12,300
+راح اشتريها وبالتالي نرجع نقول انه اي شيء يمكن ضبط
+
+85
+00:07:12,300 --> 00:07:18,100
+صفاته يصح بيعه سلاماوما لا يمكن ضبط صفاته لا يصح
+
+86
+00:07:18,100 --> 00:07:22,820
+بيعه سلامًا الأشياء التي يصح ضبط صفاتها الموزونات
+
+87
+00:07:22,820 --> 00:07:27,240
+والمكيلات والعدديات على التفصيل الذي ذكرته قبل
+
+88
+00:07:27,240 --> 00:07:32,460
+قليل يجرى الأمور التي لا يمكن ضبط صفاتها بالوصف
+
+89
+00:07:32,960 --> 00:07:38,980
+الجواهر واللقالق مثلا ما بصح فيها السلام لأنه لا
+
+90
+00:07:38,980 --> 00:07:44,540
+يمكن ضبط صفاتها بالوصف اليوم أنا لما بروح لتاجر
+
+91
+00:07:44,540 --> 00:07:51,620
+مثلا تاجر مجوهرات أتفج معاه على إنه يجهزلي بشهر
+
+92
+00:07:51,620 --> 00:07:56,840
+سبعة مثلا سبعمائة جرام من الجواهر الثمينة أو من
+
+93
+00:07:56,840 --> 00:08:02,820
+اللقالق مثلافبنقول مابيجوز ليش؟ لأنه انا شو ما
+
+94
+00:08:02,820 --> 00:08:07,480
+قديته أوصاف لن تتحقق بالتسليم لما يسلمني هتكون
+
+95
+00:08:07,480 --> 00:08:12,980
+ناقصة لأنه فرضا قلتله ال 700 جرام بتديهم عبارة عن
+
+96
+00:08:12,980 --> 00:08:18,200
+أسوارة عن خاتم عن كذا حددتله شغلات معينة الآن درجة
+
+97
+00:08:18,200 --> 00:08:25,720
+النقاء هتختلف درجة الصفاء لأن الجواهرهلاجي في شغلة
+
+98
+00:08:25,720 --> 00:08:32,340
+درجة صفاقها مثلا 90% ايش درجة صفاقه 80% ايش كذا طب
+
+99
+00:08:32,340 --> 00:08:37,220
+انا قديته حجم معين هو لم يتحكم حتى كمان في التصنيع
+
+100
+00:08:37,220 --> 00:08:43,000
+المجوهرات مش زي الدهب يصعب تشكيلها يصعب تشكيلها
+
+101
+00:08:43,000 --> 00:08:47,780
+وبالتالي مهما حاول يلتزن بالأوصاف اللي اعطيتهياها
+
+102
+00:08:47,780 --> 00:08:51,520
+فمثلا انا قلتله بدي الخاتم وزمه مايزدش عن عشر
+
+103
+00:08:51,520 --> 00:08:57,700
+جرامات مثلاهو لن يستطيع أن يتقيم لأنه مافيه قالب
+
+104
+00:08:57,700 --> 00:09:02,340
+معين تشكيل صعب وبالتالي ممكن يصل لعشر جرامات و هو
+
+105
+00:09:02,340 --> 00:09:06,080
+لسه الخاتم ضايله شغل صغيرة لا يكتمل وبالتالي هيزيد
+
+106
+00:09:06,080 --> 00:09:10,320
+عن عشرة أو هينقص عن عشرة وها كذا فبالتالي هذه
+
+107
+00:09:10,320 --> 00:09:15,440
+الجواهر مما لا يمكن ضبط صفتها وبالتالي لا يصح
+
+108
+00:09:15,440 --> 00:09:20,740
+بيعها سلاما الأمر نفسه يقال بالنسبة للحيوانات الله
+
+109
+00:09:20,740 --> 00:09:26,470
+يكرمكمالان انا بدي اروح اشتري مثلا خليني اقول ميت
+
+110
+00:09:26,470 --> 00:09:31,090
+خروف الان بهذا الشهر .. شهر ايش احنا؟ بشهر رمضان
+
+111
+00:09:31,090 --> 00:09:37,670
+عيد الأضحى بذلحجة فانا روحت اتفقت مع حدا انا مش
+
+112
+00:09:37,670 --> 00:09:40,790
+شايف الخراف اللي عنده انا لو شايفهم بيه عادي خلصنا
+
+113
+00:09:40,790 --> 00:09:46,570
+فإذا مع حدا اتفقت معاه يشتريلي يستوردلي مثلا مائة
+
+114
+00:09:46,570 --> 00:09:51,810
+خروف بمواصفات واحد اتنين تلاتةبدون ما يبعتلي صور
+
+115
+00:09:51,810 --> 00:09:55,850
+وكذا، بدي يصيرها ده بعادي لو في أي وسيلة للرؤية،
+
+116
+00:09:55,850 --> 00:10:01,090
+لأ باتحدث عن خراف مثلا مش موجودة، فانا روحت
+
+117
+00:10:01,090 --> 00:10:07,240
+اتوافقت معاه على ميت خروف بمواصفات معينةمهما وصفت
+
+118
+00:10:07,240 --> 00:10:11,020
+هل ممكن أنه يتقيت بالأوصاف اللي ذكرتها لأ لأن
+
+119
+00:10:11,020 --> 00:10:15,020
+أغراضي و أغراضه متفاوتة يعني أنا ممكن الخروف جاب
+
+120
+00:10:15,020 --> 00:10:21,180
+ليه بيعرج طب العرج عندي مش مشكلة عند غيري مشكلة و
+
+121
+00:10:21,180 --> 00:10:26,560
+هكذا فبالتالي هذه الحيوانات لا يمكن ضبطها بالوصف
+
+122
+00:10:26,560 --> 00:10:30,260
+وبالتالي لا يصح بيعها سلاما الأمر ذاته يقال
+
+123
+00:10:30,260 --> 00:10:34,480
+بالنسبة للدور والأراضي الآن انا لو بدي اشتري من
+
+124
+00:10:34,480 --> 00:10:41,750
+حدانمثلا تلاتة دولوم دولومات ارض انا مش شايفها انا
+
+125
+00:10:41,750 --> 00:10:44,630
+بمنطقة والارض اللى بدي اشتريها بمنطقة مختلفة يعني
+
+126
+00:10:44,630 --> 00:10:48,170
+مش جادر اروح وفي مسافة ولسة انا كمان شهرين تلاتة
+
+127
+00:10:48,170 --> 00:10:51,730
+بدي اسافر لمنطقة هذه اللى الارض اللى انا بدي
+
+128
+00:10:51,730 --> 00:10:56,090
+اشتريها فيها فانا توفقت معاه ودفعتله سلامان مبلغ
+
+129
+00:10:56,090 --> 00:11:01,310
+من النقود مقابل هذه الارض بمواصفات معينةطب أنا
+
+130
+00:11:01,310 --> 00:11:05,710
+الأرض كلنا بنعرف أن الجيران لهم دور في سعرها صح
+
+131
+00:11:05,710 --> 00:11:09,810
+ولا لأ؟ حدودها من هنا شارع ولا مش شارع؟ شارع عام؟
+
+132
+00:11:09,810 --> 00:11:14,370
+شارع فرعي؟ مدخل مش مدخل؟ ابصى شو؟ فكل هذه لها دور
+
+133
+00:11:14,370 --> 00:11:19,110
+في سعرها وبالتالي مهما توفقت أنا وياكي على أوصاف
+
+134
+00:11:19,110 --> 00:11:24,670
+ستبقى هناك أمور عالقةوعند الرؤية قد لا تتفق مع
+
+135
+00:11:24,670 --> 00:11:27,770
+الأوصاف اللي كانت في ذهني، فإذا حيصير في نزاع بيني
+
+136
+00:11:27,770 --> 00:11:32,550
+وبينك، ليش؟ لأنه لا يمكن وصف الأراضي وضبطها بالوصف
+
+137
+00:11:33,020 --> 00:11:37,740
+لا يمكن ضبطها بالوصف بمعنى إنه سيبقى هناك حجم إن
+
+138
+00:11:37,740 --> 00:11:42,820
+صح التعبير من الجهالة التي تقول إلى نزاع بين
+
+139
+00:11:42,820 --> 00:11:47,220
+الطرفين فمنعا من أي نزاع من البداية بنقول إنه ما
+
+140
+00:11:47,220 --> 00:11:55,300
+بصح السلام في هذه الأراضي أيضا لا يصح السلام في كل
+
+141
+00:11:55,300 --> 00:12:03,350
+ما أثرت فيه النار شيئا أو قليا أو طبخاأي شئ بينعرض
+
+142
+00:12:03,350 --> 00:12:08,270
+على النار سواء شوي أو طبيخ أو جالي أو شق أي شئ من
+
+143
+00:12:08,270 --> 00:12:12,790
+هذا القبيل ما بالصح بيعه سلامًا ما تقوليلي طب ما
+
+144
+00:12:12,790 --> 00:12:16,990
+احنا عادي برمضان فيه اجونا ضيوف فجأة كذا فبنروح
+
+145
+00:12:16,990 --> 00:12:21,490
+نكلم المطبخ بيبعتلنا delivery أكيدماهينا بنشتري
+
+146
+00:12:21,490 --> 00:12:25,710
+سلام؟ هو هذا سلام؟ لأ هذا باعي عادي انت لان .. انا
+
+147
+00:12:25,710 --> 00:12:30,890
+اقولك شغل بعيدا عن السلام انت لان مطبخ او مطعم مش
+
+148
+00:12:30,890 --> 00:12:34,290
+متعاملة معاه و مابتعرفي أكله و اجيوكي ناس عن فجأة
+
+149
+00:12:34,290 --> 00:12:38,930
+و بدك .. ما .. ماعك وجد تعملي أكل و بتطلبي من مطعم
+
+150
+00:12:38,930 --> 00:12:42,870
+انت مش مجرباها قبل كده؟بالتأكيد لأ فانت بتكون مخد
+
+151
+00:12:42,870 --> 00:12:46,930
+عينة منه شايفة كذا كذا إلى غير ذلك فنحن هنا لا
+
+152
+00:12:46,930 --> 00:12:52,190
+نتحدث عن هذا الأمر اتحدث على ان انا مثلا تاجر
+
+153
+00:12:52,190 --> 00:12:57,020
+بضاعةحابة أعمل مشروع مطبخ صغير للحارة اللي أنا
+
+154
+00:12:57,020 --> 00:13:00,360
+فيها النساء اللي في هذه الحارة مجسرات لا بطبخوا
+
+155
+00:13:00,360 --> 00:13:04,660
+ولا شي فقولت فرصة لإلي أكسب أبيع عليهم أكل و أنا
+
+156
+00:13:04,660 --> 00:13:09,780
+بعرفش أصلا أطبخ أنا كتاجر بدي أفتح محل بعرفش فصرت
+
+157
+00:13:09,780 --> 00:13:15,320
+أتعقدت مع شركات أو مؤسسات أو مطابق أو كذا يوردولي
+
+158
+00:13:15,640 --> 00:13:20,020
+مثلا من الآن اتفقت معهم انه بشهر سبعة يجيبولي كمية
+
+159
+00:13:20,020 --> 00:13:23,840
+معينة من طبيخ كذا و من نجالي كذا و من مشاوي كذا
+
+160
+00:13:23,840 --> 00:13:29,820
+بمواصفات معينة هل يا صح؟ لأ مابصحش لأن تأثير النار
+
+161
+00:13:29,820 --> 00:13:34,160
+في هذا الأكل بيختلفإشي مستوي زيادة، إشي مش مستوي
+
+162
+00:13:34,160 --> 00:13:38,480
+زيادة، واوا، هنسيب نتقاتل، طب هو جابلي هذا اللي
+
+163
+00:13:38,480 --> 00:13:41,580
+أثرت فيه النار، طب بعد كده أنا بدي أرجعه،
+
+164
+00:13:41,580 --> 00:13:44,720
+ماعجبنيش، هيقوللي لأ أنا مابرجع، وبالتالي هيصير في
+
+165
+00:13:44,720 --> 00:13:50,680
+نزاع بيني وبينك، لأن تأثير النار مختلف في كذا عن
+
+166
+00:13:50,680 --> 00:13:56,080
+كذا، لذا لا يمكن ضبط صفاتهلكن أحيانا يا جماعة
+
+167
+00:13:56,080 --> 00:14:01,860
+النار قد تؤثر في بعض المبيعات ومع ذلك يجوز بيعها
+
+168
+00:14:01,860 --> 00:14:08,500
+سلاما إذا كان تأثير النار ضعيف إذا كان تأثير النار
+
+169
+00:14:08,500 --> 00:14:15,900
+ضعيفا على هذا الشيء فيصح بيعه سلاما زي مثلا تعرفوا
+
+170
+00:14:15,900 --> 00:14:22,700
+سمن حلوبيأه okay جبل ما تتعلّب تنعرض عن نار عساس
+
+171
+00:14:22,700 --> 00:14:27,280
+أي شوائب ايش تنفرز تروح على جانب بعدين هذا
+
+172
+00:14:27,280 --> 00:14:32,180
+بيعلبوها و بيبيعوها تمام؟ نفس الشيء العسل قبل ما
+
+173
+00:14:32,180 --> 00:14:35,990
+يحطوه بالمرطبانات تبعهبيعرضوه عن نار حتى يفصلوا
+
+174
+00:14:35,990 --> 00:14:40,850
+الشمع عنه لكن تأثير النار هيكون هنا ضعيف فقط من
+
+175
+00:14:40,850 --> 00:14:45,450
+أجل التمييز فقط حتى يميز العسل لوحده والشمع لوحده
+
+176
+00:14:45,450 --> 00:14:48,990
+و هناك في السمن السمن الأنفحة لوحدها والسمنة
+
+177
+00:14:48,990 --> 00:14:53,670
+لوحدها فإذا فقط من أجل التمييز حينها مافي مشكلة
+
+178
+00:14:53,670 --> 00:14:58,930
+أنا أبيع السمن مثلا سلمان أبيع العسل سلمان مع إنه
+
+179
+00:14:58,930 --> 00:15:04,140
+انعرض على النارليش؟ لأن تأثير النار كان ضعيفا فيصح
+
+180
+00:15:04,140 --> 00:15:10,260
+بيعه سلاما تمام هذا بالنسبة لأول شرط من شروط
+
+181
+00:15:10,260 --> 00:15:15,920
+المسلم فيه، في أي سؤال؟كمان ضلتها شغلة صغيرة و هي
+
+182
+00:15:15,920 --> 00:15:23,860
+قضية جلود البقر مثلا اليوم في ناس كتير بهمها تشتري
+
+183
+00:15:23,860 --> 00:15:28,080
+جلود البقر يعني اللي بتروح للجزارين و بتحجز و
+
+184
+00:15:28,080 --> 00:15:33,010
+بتشتري شيرة عادي، الآن بدنا نتحدث عن سلامقبل ما
+
+185
+00:15:33,010 --> 00:15:38,030
+يصير دبح او اي شي أنا بكون عقدة عقد مع تجار
+
+186
+00:15:38,030 --> 00:15:44,130
+الأبقار مثلا او كذا انه اي جلد بشهر خمسة بدك
+
+187
+00:15:44,130 --> 00:15:48,210
+تسلمنيها جلود البقار او ال .. بغض النظر ايش
+
+188
+00:15:48,210 --> 00:15:53,750
+الحيوان اللي اندبح واتفقت معاه على مثلا مية جلد
+
+189
+00:15:53,750 --> 00:16:00,200
+بقرة او كذا بغض النظرطبعا ما بصح ليش؟ لأن الجلد لا
+
+190
+00:16:00,200 --> 00:16:05,320
+يمكن وصفه لحظة انا ما بقول ما بنفع بيعه بيع عادي
+
+191
+00:16:05,320 --> 00:16:09,420
+مش مشكلة لكن انا اتحدث عن بيئه salaman ما بينفعش
+
+192
+00:16:09,420 --> 00:16:13,500
+لأنه salaman لازم يكون موصف في الذمة وهذه الجنود
+
+193
+00:16:13,500 --> 00:16:18,180
+لا يمكن تضبط صفاتها لأن في جلد رقيق في جلد سميك
+
+194
+00:16:18,180 --> 00:16:23,330
+فهذا بيختلف وفبالتأكيدأنا مثلا بدي أستفيد من الجلد
+
+195
+00:16:23,330 --> 00:16:26,950
+في صناعة أحذية أو في صناعة شناط أو في كذا فهذا
+
+196
+00:16:26,950 --> 00:16:32,730
+ممكن يصلح وهذا لا يصلح وبالتالي مش هأقدر أنا أطبط
+
+197
+00:16:32,730 --> 00:16:37,030
+الصفات اللي بديها لأن هو و هو بيتبح مش هيكون عارف
+
+198
+00:16:37,030 --> 00:16:40,730
+إن هذا الجلد زي ما أنا بدي أو لأ غير بعد الدبح
+
+199
+00:16:40,730 --> 00:16:45,030
+هيكتشف صح ولا لا وبالتالي هيصير في نزاع بيني وبينه
+
+200
+00:16:45,030 --> 00:16:50,280
+لذا لا يصح السلام في مثلي هذاالأمر أيضًا لماذا؟
+
+201
+00:16:50,280 --> 00:16:55,520
+لأنه لا يمكن ضبط صفاته بالوصف باعتبار أن الثمن
+
+202
+00:16:55,520 --> 00:17:01,460
+يختلف باختلاف هذه الأوصاف تمام؟ واضح؟ نيجي الآن
+
+203
+00:17:01,460 --> 00:17:13,520
+للشرط الثاني يلا يا زينب برك
+
+204
+00:17:13,520 --> 00:17:20,760
+الله فيكتحدثنا في المبيع في عقد البيأ وقلنا يجب أن
+
+205
+00:17:20,760 --> 00:17:26,920
+يكون معلوما هنا أيضا نكرر ونقول أنه لابد في المسلم
+
+206
+00:17:26,920 --> 00:17:38,080
+فيه أن يكون معلوما ببيان جنسه ونوعه وصفته وقدره
+
+207
+00:17:41,760 --> 00:17:47,360
+يكون في علم بجنسه ابتداءًا هو جمح ولا شعير، بعدين
+
+208
+00:17:47,360 --> 00:17:52,000
+لما حددنا جنسه بدنا نعرف نوعه بلدي ولا مصري ولا
+
+209
+00:17:52,000 --> 00:17:56,100
+سوداني ولا شو، بعد ما عرفنا نوعه بدنا نعرف صفته
+
+210
+00:17:56,100 --> 00:18:01,040
+أحمر ولا أصمر، وبالتالي هذه كلها الأوصاف مهمة جدا
+
+211
+00:18:01,040 --> 00:18:07,410
+للعلم بيهوإلا حيصير فيه نزاع الجهالة بالمعقود عليه
+
+212
+00:18:07,410 --> 00:18:12,150
+بالمسلم فيه مؤدها إلى نزاع بين الطرفين فمنعا من
+
+213
+00:18:12,150 --> 00:18:17,930
+حصول النزاع قلنا بوجوب معلومية الجنس والنوع والصفة
+
+214
+00:18:17,930 --> 00:18:22,510
+والقدر أيضا بدنا ندفق بدش أقوله بدي كومة قمح
+
+215
+00:18:22,510 --> 00:18:27,130
+الكومة هذه كده وزنها تلاتة طن، خمسة طن، عشرة طن،
+
+216
+00:18:27,130 --> 00:18:32,450
+وهكذابدي بطيخ بدي اقوله اتفقنا انه بينباع بالكيلو
+
+217
+00:18:32,450 --> 00:18:36,590
+بنقول بالكيلو كام من طون مثلا بطيخ حسب الشغلة اللي
+
+218
+00:18:36,590 --> 00:18:41,390
+انا بدي اشتريها فما بصير انا اروح اطلب منه شغلة
+
+219
+00:18:41,390 --> 00:18:46,530
+بوصف الناقص اقوله مثلا بدي جمح تلاتة طون جمح بدون
+
+220
+00:18:46,530 --> 00:18:51,110
+ما اقوله ايش نوع الجمح ايش أوصافه ايش كذا لأ فلازم
+
+221
+00:18:51,110 --> 00:18:56,450
+احدد كل شئ لأن فرضا انا طلبت منك تلاتة طون جمح طب
+
+222
+00:18:56,450 --> 00:19:00,740
+وقت التسليم سلمتني انتكلفتي حالك و جبتي ليهم
+
+223
+00:19:00,740 --> 00:19:04,560
+لعندي، فأنا ابطلعت، قولت نعم، و أنت مش لاجئ تجيبلي
+
+224
+00:19:04,560 --> 00:19:07,980
+إلا جمح سوداني، أنا بدي بلدي، من تبعي البلد، أنا
+
+225
+00:19:07,980 --> 00:19:11,800
+ما .. بستخدمش إلا تبعي البلد، أنت ما حكيتوا، طب ما
+
+226
+00:19:11,800 --> 00:19:16,040
+أنا كان قصدي واضح و قعدنا إيش نتجاتلفمنعا من إنه
+
+227
+00:19:16,040 --> 00:19:20,260
+نصل لهذه المرحلة من البداية بدنا يكون لدينا علم
+
+228
+00:19:20,260 --> 00:19:27,020
+بكل هذه الأمور كي لا نقع في أي جهالة تودي بنا إلى
+
+229
+00:19:27,020 --> 00:19:32,180
+نزاع تمام هذا بالنسبة للشرط الثاني نجي للشرط
+
+230
+00:19:32,180 --> 00:19:38,220
+الثالث يلا اسلام هل يكون مختلفة من أجنات المتخلصة
+
+231
+00:19:38,220 --> 00:19:42,000
+كعلق مطلوب من شعير و درع و نسبة كل جنس في الخليفة
+
+232
+00:19:42,000 --> 00:19:49,590
+مجموعة بارك الله فيكيجب في المسلم فيه ألا يكون
+
+233
+00:19:49,590 --> 00:19:58,610
+مختلط بأجناس مختلطة ونسبة كل خليط مجهولة الآن مرة
+
+234
+00:19:58,610 --> 00:20:03,390
+تانية بنقول إن المسلم فيه لازم مايكونش مختلط
+
+235
+00:20:03,390 --> 00:20:11,390
+بأجناس مختلفة ونسبة كل خليط مجهولة يعني أجي أنا
+
+236
+00:20:11,390 --> 00:20:17,610
+أتفج معك على مثلا عشرة طول من العلفوالعلف عبارة عن
+
+237
+00:20:17,610 --> 00:20:24,010
+دره و الشعير و .. وش كمان؟ دره و الشعير و جمح مثلا
+
+238
+00:20:24,010 --> 00:20:30,890
+تمام؟ خليطو بدون ما أدفج معاك على نسبة كل من الدرع
+
+239
+00:20:30,890 --> 00:20:34,890
+و الشعير و الجمح بس قلتلك أنه بدي منك عشرة طن من
+
+240
+00:20:34,890 --> 00:20:39,970
+العلف اللي فيه جمح و شعير و درع بنفع؟ لأ بنفعش لأن
+
+241
+00:20:39,970 --> 00:20:45,050
+وقت التسليم استلمت أنا ربما ألاجي الشعير أكتر أجي
+
+242
+00:20:45,050 --> 00:20:49,110
+أقولك لأ أنا بدي درع أكتروربما ألاقي حاجة أكتر من
+
+243
+00:20:49,110 --> 00:20:52,010
+التانية أو ألاقيهم زي بعد أقول لأ أنا بدي إشي أكتر
+
+244
+00:20:52,010 --> 00:20:57,070
+من إشي و هكذا فإذا حيصير في نزاع فإذا إذا أنا بعت
+
+245
+00:20:57,070 --> 00:21:03,270
+خليط من كذا جنس و نسبة كل جنس مختلفة مجهولة خليني
+
+246
+00:21:03,270 --> 00:21:08,410
+أقول فحينها لا يصح السلاموبالتالي في استثنائين
+
+247
+00:21:08,410 --> 00:21:16,550
+حينها يجوز أن يكون المسلم فيه صحيح حتى مع اختلاطه
+
+248
+00:21:16,550 --> 00:21:22,070
+بغيره الاستثنائين الاول منهما اذا كانت نسبة كل
+
+249
+00:21:22,070 --> 00:21:28,430
+خليط معلومة يعني انا اتفقت معك على تلاتة طن من
+
+250
+00:21:28,430 --> 00:21:33,530
+العلف اللي هو عبارة عن دره والشعيرتفاجد بشرط ان
+
+251
+00:21:33,530 --> 00:21:37,810
+تكون النسبة بين الدرة و الشعير 2 ل 1 خلاص 2 ل 1
+
+252
+00:21:37,810 --> 00:21:42,350
+يعني تلتين درة و تلت شعير او اقولك بنسبة واحد ل
+
+253
+00:21:42,350 --> 00:21:47,630
+واحد يعني نصه درة و نصه شعير او بنسبة تلات ل اتنين
+
+254
+00:21:47,630 --> 00:21:51,540
+ل واحد اذا كانوا تلات شغلاتوبدأ أحددك مين فيهم
+
+255
+00:21:51,540 --> 00:21:54,680
+التلاتة ومين فيهم الأتنين ومين فيهم الواحد فمافي
+
+256
+00:21:54,680 --> 00:22:00,020
+أي مشكلة طالما أن نسبة كل خليط معلومة المشكلة إذا
+
+257
+00:22:00,020 --> 00:22:04,480
+كانت الخليط أو الأجناس اللي في الخليط مجهولة وقتها
+
+258
+00:22:04,480 --> 00:22:10,300
+مابينفاج وبيكون السلام مش صحيح ليش؟ لأن وقتها في
+
+259
+00:22:10,300 --> 00:22:14,900
+جهالة وبالتالي في نزاع بين الأطراف هذا الاستثناء
+
+260
+00:22:14,900 --> 00:22:17,220
+الأول الاستثناء الثاني
+
+261
+00:22:21,210 --> 00:22:27,110
+إذا كان الخليط أو الخلط لابد منه لمصلحتي المسلم
+
+262
+00:22:27,110 --> 00:22:33,690
+فيه يعني أنا الآن بتعرفوا قبل طبعا أغلب الناس
+
+263
+00:22:33,690 --> 00:22:37,530
+بالعادة بيفطروا جبنة صح؟ يعني الجبنة أساسية في
+
+264
+00:22:37,530 --> 00:22:42,230
+الفطور تعتبر عند الكثيرين برمضان كمان الطلب عليها
+
+265
+00:22:42,230 --> 00:22:48,420
+بزيتفالتجار قبل شهر رمضان بيروحوا قاش بنا نفطر
+
+266
+00:22:48,420 --> 00:22:52,240
+اللي بدهم يشتريه سلام أشبان الجبن البيضا البلدية
+
+267
+00:22:52,240 --> 00:22:57,760
+اللي بنقول عنها فالجبن هذا اللي بدهم يشتروه
+
+268
+00:22:57,760 --> 00:23:02,000
+فبيتفجوا مثلا هم بيكونوا متفجين من شهر اتنين انه
+
+269
+00:23:02,000 --> 00:23:07,020
+بواحد اربعة سلمنا مثلا خليني اجول طن من الجبنة
+
+270
+00:23:07,020 --> 00:23:12,710
+البلديةالأصل إنها تكون مش مختلطة بغيرها، لكن اليوم
+
+271
+00:23:12,710 --> 00:23:17,210
+الجبنة أصلا بتنحت في الأنفحة، ليحفظيها، صح ولا لأ؟
+
+272
+00:23:17,210 --> 00:23:20,730
+اليوم عادي جدا لما بدك تشتري من الكفتيريا ساندويشة
+
+273
+00:23:20,730 --> 00:23:24,110
+تشتريها كده، لأنه أنت هتاكليها فمش هتتلف يعني، مش
+
+274
+00:23:24,110 --> 00:23:28,160
+هتلحقتتلف لأنك على طول بلعتيها صح ولا لأ لكن انت
+
+275
+00:23:28,160 --> 00:23:32,000
+بتشتري كمية كبيرة فهذه مش هتسمت بدون ما تكون
+
+276
+00:23:32,000 --> 00:23:36,400
+محفوظة بالأنفحة تبعها صح ولا لأ فلذلك لحظي معايا
+
+277
+00:23:36,400 --> 00:23:41,240
+الجبن موجودة في أنفحة يعني في خليط ومع ذلك يجوز
+
+278
+00:23:41,240 --> 00:23:46,580
+ويصح البيع سلاما ليش؟ لأن هذا الخلط كان لابد منه
+
+279
+00:23:46,580 --> 00:23:53,410
+لحفظها حينها يصح عقد السلام واضح؟ تمام؟ طيبهذا
+
+280
+00:23:53,410 --> 00:23:59,870
+بالنسبة للشرط التالت نجي للشرط الرابع وبه نختم
+
+281
+00:23:59,870 --> 00:24:09,050
+الشرط الرابع يلا
+
+282
+00:24:12,620 --> 00:24:17,460
+برك الله فيك، إذا لابد في المسلم فيه أن يكون دينا،
+
+283
+00:24:17,460 --> 00:24:23,580
+شو يعني دينا؟ يعني موصوفا في الذمة، لازم لازم
+
+284
+00:24:23,580 --> 00:24:30,120
+المسلم فيه مايكلش عين لأن أنا أتحدث عن بيع شئ غير
+
+285
+00:24:30,120 --> 00:24:35,800
+موشوق، بيع معدوموالمعدوم هذا يجب أن يكون دينا
+
+286
+00:24:35,800 --> 00:24:41,400
+موصوفا في الذمة يعني ممكن أنه يثبت في ذمتي وبناء
+
+287
+00:24:41,400 --> 00:24:46,360
+على ذلك ما بيصير يكون عندي هنا قومة أو كومة من
+
+288
+00:24:46,360 --> 00:24:53,760
+القمح مثلا واجي أقولك أسلمتك الألف دينار في هذه أو
+
+289
+00:24:53,760 --> 00:25:01,300
+في هذا القمح أسلمتك الألف دينار في هذا القمحطبعا
+
+290
+00:25:01,300 --> 00:25:06,760
+لا يصح لا يصح لا سلام ولا بيع ما بصح سلام لأن
+
+291
+00:25:06,760 --> 00:25:12,280
+السلم يقتضي أن يكون موصوف في الذمة وليس معينا وليس
+
+292
+00:25:12,280 --> 00:25:19,240
+عينا كونه هنا معينا وعينا فلا يصح سلما وأيضا لا
+
+293
+00:25:19,240 --> 00:25:26,220
+يصح بيعا لأن صيغة العقد إيش كانت أسلام توكيهو هذه
+
+294
+00:25:26,220 --> 00:25:30,680
+الصيغة تستدعي أن يكون المسلم فيه أو المعقود عليه
+
+295
+00:25:30,680 --> 00:25:37,800
+موصوفا في الذمة و ليس معينا، ليس حاضرا، غير موجودا
+
+296
+00:25:37,800 --> 00:25:42,120
+وبالتالي فلحظي معايا لما قلتلك أسلمتك الألف دينار
+
+297
+00:25:42,120 --> 00:25:47,700
+في هذا القمح لا بينفع لا سلامولا بيع وعرفنا ليش؟
+
+298
+00:25:47,700 --> 00:25:51,700
+مابينفعش سلام لأنه لازم يكون موصوف وهذا معين إذا
+
+299
+00:25:51,700 --> 00:25:57,660
+بينفعش وكمان مابينفعش بيع لأني تلفظت بصيغة السلام
+
+300
+00:25:57,660 --> 00:26:04,340
+وهذه الصيغة تستلزم أن يكون المعقود عليه غير موجود
+
+301
+00:26:04,340 --> 00:26:12,220
+يعني دين موصوف في الذمة تمام؟ في أي سؤال؟ لا سمح
+
+302
+00:26:12,220 --> 00:26:18,660
+اللهتمام؟ طيب إلى هنا نكون قد انتهينا من موضوع
+
+303
+00:26:18,660 --> 00:26:23,240
+محاضرتنا لهذا اليوم المحاضرة القادمة بإذن الله
+
+304
+00:26:23,240 --> 00:26:29,600
+سنتحدث حول تتمة شروط المعقود عليه ثم حول تطبيقات
+
+305
+00:26:29,600 --> 00:26:33,840
+عقد السلام المعاصرة أقول قولي هذا وأستغفر الله لي
+
+306
+00:26:33,840 --> 00:26:38,900
+ولكم وصلى اللهم وسلم وبارك على سيدنا محمد والسلام
+
+307
+00:26:38,900 --> 00:26:41,320
+عليكم ورحمة الله تعالى وبركاته
+
diff --git a/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/67RMIhSSgcI_postprocess.srt b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/67RMIhSSgcI_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..0370a2dfc8e76f2a10627507ce59d2af58654b12
--- /dev/null
+++ b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/67RMIhSSgcI_postprocess.srt
@@ -0,0 +1,1400 @@
+1
+00:00:05,530 --> 00:00:08,390
+أعوذ بالله السماء العليه من الشيطان الراجيم بسم
+
+2
+00:00:08,390 --> 00:00:11,670
+الله الرحمن الرحيم الحمد لله رب العالمين والصلاة
+
+3
+00:00:11,670 --> 00:00:15,770
+والسلام على أشرف الأنبياء والمرسلين سيدنا محمد بن
+
+4
+00:00:15,770 --> 00:00:18,730
+عبدالله الصادق الأمين ثم أما بعد أحييكم جميعا
+
+5
+00:00:18,730 --> 00:00:22,210
+بتحية الإسلام في السلام عليكم ورحمة الله تعالى
+
+6
+00:00:22,210 --> 00:00:27,930
+وبركاته كيف حالكوا طيبات ان شاء الله؟تحضرنا جيد ان
+
+7
+00:00:27,930 --> 00:00:32,830
+شاء الله؟ طيب عظيم إذا المحاضرة السابقة كنا قد
+
+8
+00:00:32,830 --> 00:00:37,230
+انتهينا من الحديث حول خيار المجلس عرفنا أن هذا
+
+9
+00:00:37,230 --> 00:00:41,750
+الخيار هو حق شرعي يمنحه للمتعاقدين طالما أنهم في
+
+10
+00:00:41,750 --> 00:00:46,210
+مجلس العقد ولم يخترع الإمضاء وبالتاليفإن هذا
+
+11
+00:00:46,210 --> 00:00:50,390
+الخيار يثبت لكلا المتعاقدين بالشرط التي ذكرناها
+
+12
+00:00:50,390 --> 00:00:54,730
+لكن لو مات أي منهم فهل ينتقل إلى ورثته قلنا إن
+
+13
+00:00:54,730 --> 00:00:59,830
+هناك خلاف بين الشفعية والحنابلة فصلناه سابقا ثم
+
+14
+00:00:59,830 --> 00:01:04,050
+تحدثنا عن أن هذا الخيار يصح فقط في العقود اللازمة
+
+15
+00:01:04,050 --> 00:01:08,270
+التي تقبل الفسخ بالإقالة كعقد البيعثم انتهينا
+
+16
+00:01:08,270 --> 00:01:12,190
+بالحديث عن مسقطاته وقلنا إن خيار المجلس يسقط
+
+17
+00:01:12,190 --> 00:01:17,030
+بالتفرق من مجلس العقد و بالاختيار و بهلاك المعقود
+
+18
+00:01:17,030 --> 00:01:22,150
+عليه في مجلس العقد اليوم بإذن الله سنتحدث حول خيار
+
+19
+00:01:22,150 --> 00:01:27,060
+الشرططبيعي جدا أن نبدأ بتعريف هذا الخيار وخيار
+
+20
+00:01:27,060 --> 00:01:32,400
+الشرط تعريفه بيستلزم أن نعرف إيش مفرداته لأن في
+
+21
+00:01:32,400 --> 00:01:35,660
+عندي خيار وفي عندي شرط ثم أتحدث عن خيار الشرط
+
+22
+00:01:35,660 --> 00:01:39,560
+كمصطلح مركب يلا مع بعض سريعا الخيار شهو هو اللي
+
+23
+00:01:39,560 --> 00:01:44,200
+أخدناه قبل عشرين سنة من هذا الفصل يلا الخيار
+
+24
+00:01:44,200 --> 00:01:47,840
+الخيار بحد ذاته مش خيار الشرط شهو هو الخيار اتفضلي
+
+25
+00:01:51,240 --> 00:01:54,200
+بارك الله فيك، إذا الخيار هو طلبه خير الأمرين إما
+
+26
+00:01:54,200 --> 00:01:59,300
+الإمضاء أو الفسق، خلصناه، طب الشرط، الشرط شهوه؟
+
+27
+00:01:59,300 --> 00:02:05,860
+بارك
+
+28
+00:02:05,860 --> 00:02:09,220
+الله فيك، طبعا هذا الكلام أخدته بعبادات واحد،
+
+29
+00:02:09,220 --> 00:02:15,840
+الشرط هو ما يلزم من عدمه اللي بصبحه يا جماعة، صلوا
+
+30
+00:02:15,840 --> 00:02:16,520
+على رسول الله
+
+31
+00:02:19,490 --> 00:02:29,090
+ما يلزم من عدمه العدم ولا يلزم من وجوده وجوده ولا
+
+32
+00:02:29,090 --> 00:02:35,190
+عدم، ولا عدم الآن باختصار الطهارة أو الوضوء
+
+33
+00:02:35,190 --> 00:02:40,380
+بالنسبة للصلاةجمع حد شي حكي راجعا سريعا، بدي أحكي
+
+34
+00:02:40,380 --> 00:02:45,320
+و نخلص النقطة هاي، الآن الطهارة بالنسبة للصلاة شرط
+
+35
+00:02:45,320 --> 00:02:50,180
+لصحتها، فنجي للتعريف، ما يلزم من عدمه العدم يلزم
+
+36
+00:02:50,180 --> 00:02:54,780
+من عدم وجود و ضوء عدم صحة الصلاة، صح ولا لا؟ أنا
+
+37
+00:02:54,780 --> 00:02:59,890
+مش متواضعة، بصير أصلي؟بتاكد لأ، طيب، هل يلزم من
+
+38
+00:02:59,890 --> 00:03:04,910
+كوني متواضعة أن أصلي أو لا أصلي؟ طبعا لأ، لا، لا
+
+39
+00:03:04,910 --> 00:03:09,050
+يلزم، أنا متواضعة هالجهد، هل لأني متواضعة لازم
+
+40
+00:03:09,050 --> 00:03:14,590
+أصلي؟ طيب، هل لأني متواضعة لازم ما أصليش؟ برضه لأ،
+
+41
+00:03:14,590 --> 00:03:17,550
+يعني لا يلزم، لا وجود ولا عدم، كوني متواضعة، لكن
+
+42
+00:03:17,550 --> 00:03:23,310
+كوني مش متواضعة، يلزم عدم صحة الصلاة علم؟ هذا هو
+
+43
+00:03:23,310 --> 00:03:28,700
+الشرط، الآن خيار الشرطخيار الشرط، يلا مين تعرفني
+
+44
+00:03:28,700 --> 00:03:34,760
+خيار الشرط، شو هو؟
+
+45
+00:03:34,760 --> 00:03:43,260
+يلا بارك
+
+46
+00:03:43,260 --> 00:03:48,540
+الله فيك، حق يثبت
+
+47
+00:03:48,540 --> 00:03:54,900
+لمن اشترته من المتعاقدين
+
+48
+00:03:57,330 --> 00:04:01,730
+تمام؟ طبعا الحق يثبت في شو في اختيار اما امضاء
+
+49
+00:04:01,730 --> 00:04:08,530
+العقد لأن هي فلسفة الخيار بشكل عام امضاء او فسخ او
+
+50
+00:04:08,530 --> 00:04:16,050
+فسخه لكن ايش؟ خلال مدة معلومة و هنتحدث عنها
+
+51
+00:04:16,050 --> 00:04:20,770
+المحاضرة القادمة بإذن الله موضوع المدة الان لاحظي
+
+52
+00:04:20,770 --> 00:04:27,270
+نرجع حقيثبت لمن اشترته لاحظى في خيار لازم نقارن في
+
+53
+00:04:27,270 --> 00:04:33,070
+خيار المجلس كنا بنقول حق شر يثبت للتانين لكن
+
+54
+00:04:33,070 --> 00:04:41,290
+المتعاقدين صح هنا بنقول حق يثبت للذي اشترتهبمعنى
+
+55
+00:04:41,290 --> 00:04:46,950
+أن هذا الحق لا يمنحه تلقائيًا بوجودي في مجلس العقد
+
+56
+00:04:46,950 --> 00:04:52,310
+بل يمنحه إذا اشترته و للذي اشترته بمعنى آخر أنا
+
+57
+00:04:52,310 --> 00:04:56,710
+ممكن أعقد باعة و لا أشترت خيار ولا الطرف التاني
+
+58
+00:04:56,710 --> 00:05:00,450
+اشترت بنفع؟ اه بنفع مش اي مشكلة انت بتشتري شنطة و
+
+59
+00:05:00,450 --> 00:05:05,210
+بتروحيوماقلت للبياعي بشرط بدي يمكن بكرا أبدلها او
+
+60
+00:05:05,210 --> 00:05:10,030
+او او إلى غير ذلك واخدتها ومشيت تاني يوم ماعجبتك
+
+61
+00:05:10,030 --> 00:05:15,410
+او اي شي بدك ترجعيه هرضي من ذاته مارضيش هل تملكينا
+
+62
+00:05:15,410 --> 00:05:21,310
+إجباره؟ بالتأكيد لأ لاتملكينا إجباره ليش؟ لأنه لم
+
+63
+00:05:21,310 --> 00:05:26,520
+تشتريت الخيارة لنفسكفبالتالي هذا الحق يثبت فقط
+
+64
+00:05:26,520 --> 00:05:32,040
+للذي اشترته سواء كان هو البائع أو المشتري أو هم
+
+65
+00:05:32,040 --> 00:05:36,220
+التنين أو أجنبي عشان هيك كمان شوية لما بنتحدث لمن
+
+66
+00:05:36,220 --> 00:05:40,600
+يثبت هنعرف الأربع اللي حكيناهم قبل شوية أو تلتهم
+
+67
+00:05:40,600 --> 00:05:46,880
+بالأحرىتمام؟ فإذا الذي اشترط هذا الخيار بدي يصير
+
+68
+00:05:46,880 --> 00:05:53,840
+هو وحده فقط الذي يحق له أن يمضي العقد أو أن يفسخه
+
+69
+00:05:53,840 --> 00:05:58,840
+لكن خلال مدة معينة مش معنى الكلام في إيه ليه خيار
+
+70
+00:05:58,840 --> 00:06:04,060
+يعني وجهة ما بدي لأ خلال المدة المتفق عليهاأقصاها
+
+71
+00:06:04,060 --> 00:06:09,040
+كما سنعلم ثلاثة أيام على الراجح تمام هذا بالنسبة
+
+72
+00:06:09,040 --> 00:06:15,740
+لخيار الشرط أو مفهوم خيار الشرط نيجي الأن نتحدث عن
+
+73
+00:06:15,740 --> 00:06:21,420
+مشروعيته نتذكر برضه خيار المجلس خيار المجلس بقولنا
+
+74
+00:06:21,420 --> 00:06:25,980
+أن الحنافية والمالكية قالوا بعدم مشروعيته الذي قال
+
+75
+00:06:25,980 --> 00:06:31,530
+بمشروعيته شفعية وحنابلة وأكثر أهل العلمهذا الخيار
+
+76
+00:06:31,530 --> 00:06:36,550
+أي خيار الشرط الذين قالوا بمشروعيته الأام الأربع
+
+77
+00:06:36,550 --> 00:06:40,590
+بمعنى منهم الحنفية والمالكية اللي هناك قالوا لأ
+
+78
+00:06:40,590 --> 00:06:46,110
+جميع الأام الأربع قالوا بمشروعية خيار الشرط
+
+79
+00:06:46,110 --> 00:06:51,630
+واستدلوا على جوازه وعلى مشروعيته بأدلة من السنة
+
+80
+00:06:51,630 --> 00:06:57,010
+النبوية ومن المعقول أما من السنة .. يلا نشوفيلا
+
+81
+00:06:57,010 --> 00:07:00,490
+اسلام عن عبد الله بن عمر رضي الله عنهما أن رجلا
+
+82
+00:07:00,490 --> 00:07:04,350
+ذكر للنبي صلى الله عليه وسلم أنه يخدع في البيوع
+
+83
+00:07:04,350 --> 00:07:10,070
+فقال إذا باعت فقول لا خلابة وفي رواية ولي الخيار
+
+84
+00:07:10,070 --> 00:07:15,370
+ثلاثة أيام بارك الله فيك إذا ما رواه عبد الله بن
+
+85
+00:07:15,370 --> 00:07:20,590
+عمر رضي الله عنهما أن النبي صلى الله عليه وسلم قال
+
+86
+00:07:20,590 --> 00:07:22,630
+للذي يخدع في البيوع
+
+87
+00:07:36,700 --> 00:07:45,560
+طب أنا بدي أوقف أستاذ أنا لأني مافهمت هو
+
+88
+00:07:45,560 --> 00:08:01,140
+أنا مش .. okay طيب
+
+89
+00:08:01,140 --> 00:08:04,460
+إذا
+
+90
+00:08:05,540 --> 00:08:09,960
+فقال صلى الله عليه وسلم للذي يخدع في البيوع إذا
+
+91
+00:08:09,960 --> 00:08:16,080
+بايع تفقل لا خلابة ولي الخيار ثلاثة أيام لحظة
+
+92
+00:08:16,080 --> 00:08:20,060
+معايا هذا الرجل .. اذا كمل الحديث سابقا هذا الرجل
+
+93
+00:08:20,060 --> 00:08:24,060
+الذي دائما ما يخدع في بيوعه يروح يشتر أو يبيع
+
+94
+00:08:24,060 --> 00:08:29,230
+بنضحك عليهفجاء للنبي صلى الله عليه وسلم ليرشده ما
+
+95
+00:08:29,230 --> 00:08:33,350
+الحل يا رسول الله دائما كذا كذا كذا فقال له صلى
+
+96
+00:08:33,350 --> 00:08:38,330
+الله عليه وسلم إذا باعت فقول لا خلابة لا خداع لا
+
+97
+00:08:38,330 --> 00:08:44,230
+غشوفي رواية أكمل له صلى الله عليه وسلم قائلا ولي
+
+98
+00:08:44,230 --> 00:08:50,630
+الخيار ثلاثة أيام طبعا هذا الحديث فيه دلالة واضحة
+
+99
+00:08:50,630 --> 00:08:54,550
+وصريحة على مشروعية خيار المجلس أن هذا الرجل الذي
+
+100
+00:08:54,550 --> 00:09:00,010
+دائما يخدع في بيوعه إذا قال للبائع إن كان هو
+
+101
+00:09:00,010 --> 00:09:05,230
+المشتري لي الخيار ثلاثة أيام طبيعي جدا إذا هو ما
+
+102
+00:09:05,230 --> 00:09:08,390
+عنده خبرة في البيع كذا لما بيروّع البيت باستشير
+
+103
+00:09:09,060 --> 00:09:14,740
+المدامة بتشير عليه و بيروح فبالتالي وقتها بيرتفع
+
+104
+00:09:14,740 --> 00:09:20,380
+أي غش و أي خداع قد يلحق بهذا الذي يخدع فهذا دليل
+
+105
+00:09:20,380 --> 00:09:26,360
+واضح على مشروعية خيار الشرط أيضا يقول صلى الله
+
+106
+00:09:26,360 --> 00:09:27,500
+عليه وسلم
+
+107
+00:09:33,070 --> 00:09:36,510
+برك الله فيك إذا يقول صلى الله عليه وسلم المسلمون
+
+108
+00:09:36,510 --> 00:09:45,050
+عند شروطهم إلا شرطا أحلى حراما أو حرم حلالة الحديث
+
+109
+00:09:45,050 --> 00:09:49,390
+واضح في دلالته أنه يجوز للإنسان أن يشترط لنفسه ما
+
+110
+00:09:49,390 --> 00:09:55,660
+شاء من الشروط ما دامت لا تحل الحرام ولا تحرمالحلال
+
+111
+00:09:55,660 --> 00:10:00,980
+فإذا خيار الشرط من هذه الشروط التي ليس فيها لا
+
+112
+00:10:00,980 --> 00:10:06,540
+تحليل للحرام ولا تحريم للحلال فكان مشروعا وجائزا
+
+113
+00:10:06,540 --> 00:10:14,060
+من المعقول نقولإن الحاجة تدعو لاشتراط مثل هذا
+
+114
+00:10:14,060 --> 00:10:20,260
+الخيار لأن هناك من الناس من ليس لديهم خبرة كافية
+
+115
+00:10:20,260 --> 00:10:25,600
+بالبيع و الشراء و نحوهما فيحتاج إلى أن يستشير أهل
+
+116
+00:10:25,600 --> 00:10:30,260
+الخبرة ليشيروا عليه كي لا يخدعوا و كي لا يندموا
+
+117
+00:10:30,260 --> 00:10:34,500
+على العقد الذي أبرمواو أحيانا من الناس عندهم دراية
+
+118
+00:10:34,500 --> 00:10:38,620
+بالبيع لكن ماعندهمش دراية بكل المبيعات يعني ممكن
+
+119
+00:10:38,620 --> 00:10:43,180
+أنا تاجر و مع ذلك ينضحك عليّ لأن أنا كتاجر مش
+
+120
+00:10:43,180 --> 00:10:47,140
+ضروري أكون عارفة كل ما يتعلق بكل السلع يعني أنا
+
+121
+00:10:47,140 --> 00:10:52,160
+مثلا تاجر بالسيارات شوف فهمني بالملابس مثلاأو
+
+122
+00:10:52,160 --> 00:10:57,400
+العكس فبالتالي برضه أنا حتى لو كنت تاجران أو أفهم
+
+123
+00:10:57,400 --> 00:11:01,340
+في البيع ليس شرط أن أفهم بكل المبيعات فأحيانا
+
+124
+00:11:01,340 --> 00:11:05,940
+أحتاج إلى استشارة الغير والمتخصصين من أهل الخبرة
+
+125
+00:11:05,940 --> 00:11:12,530
+في مبيع معين مثلا فكان الخياريؤدي هذا الغرض
+
+126
+00:11:12,530 --> 00:11:20,350
+وبالتالي يرفع أي خلل أو أي درر يلحق بالمتعاقد من
+
+127
+00:11:20,350 --> 00:11:25,850
+هنا شريعة هذه الخيارات تمام هذا بالنسبة لمشروعية
+
+128
+00:11:25,850 --> 00:11:32,910
+خيار الشرط نأتي الآن نتحدث عن العقود التي يصح فيها
+
+129
+00:11:32,910 --> 00:11:38,350
+خيار الشرط يلا نشوف من اتحدثنا
+
+130
+00:11:47,130 --> 00:11:51,690
+العقود التي يصح فيها خيار الشرط تفضلي يصح خيار
+
+131
+00:11:51,690 --> 00:11:55,710
+الشرط في كل أنواع البيع إلا أن يشترطوا قد مجلس
+
+132
+00:11:55,710 --> 00:12:00,530
+كبيع تعامل للتعامل واسل مصر سلام يتعارض مع شرط
+
+133
+00:12:00,530 --> 00:12:09,870
+الخيار ماشي الحال برك الله فيك إذا بنقول يصح مش
+
+134
+00:12:09,870 --> 00:12:16,930
+ضروري نمشي بالترتيب يا حلوين طيب يصح خيارالشرط
+
+135
+00:12:16,930 --> 00:12:24,030
+لحظة ايش قالك؟ في جميع أنواع
+
+136
+00:12:24,030 --> 00:12:30,070
+البيوع تمام؟
+
+137
+00:12:30,070 --> 00:12:36,750
+في جميع .. جميع عموم يعني يدخلوا الاستثناء الا الا
+
+138
+00:12:36,750 --> 00:12:44,690
+الا البيوع التي يشترطوا
+
+139
+00:12:47,830 --> 00:12:53,410
+لصحتها القبض شو معناه هذا الكلام؟ خلّيكوا معايا
+
+140
+00:12:53,410 --> 00:12:59,430
+إزاي إيش نمثللها على السريع؟ اللي هو بيع الصرف و
+
+141
+00:12:59,430 --> 00:13:06,310
+بيع السلام و بيع الطعاملأ ما تقوليش الطعام و تسكتي
+
+142
+00:13:06,310 --> 00:13:09,750
+بيع الطعام عادي جدا أشتري مثلا لحمة أو كذا و
+
+143
+00:13:09,750 --> 00:13:14,130
+ماتفعش حاجة أقوله بأول أربع مافي مشكلة لكن طعام
+
+144
+00:13:14,130 --> 00:13:17,310
+بطعام لأ لازم احنا التاني نتسلم بعيد زي ما هنعرف
+
+145
+00:13:17,310 --> 00:13:22,750
+كمان شوية بيع الطعام بالطعام طيب خليكم معايا لحظة
+
+146
+00:13:22,750 --> 00:13:28,950
+إيش جالك يصح خيار الشرط في جميع أنواع العقودالبيوع
+
+147
+00:13:28,950 --> 00:13:34,810
+عفوًا إلا البيوع اللي يشترط لصحتها القبض في مجلس
+
+148
+00:13:34,810 --> 00:13:39,290
+العقل جماعة احنا متفقين خليكم معايا عشان نفهمها صح
+
+149
+00:13:39,290 --> 00:13:46,430
+متفقين انه عادي جدا ان أجل الثمن صح هذا كمبدأ عام
+
+150
+00:13:46,430 --> 00:13:51,350
+في البيوع عادي جدا الثمن يتأجل لكن في عندنا بيوع
+
+151
+00:13:51,350 --> 00:13:57,650
+مافيش مجال الثمن يتأجلالثمن كأيوات يعني مافيش مجال
+
+152
+00:13:57,650 --> 00:14:02,250
+يتأجل زي بيع الصرف اللي هو النقد بالنقد لما تروحي
+
+153
+00:14:02,250 --> 00:14:06,890
+تبيعي دينار بشكل دينار بدولار لازم تسلمي و تستلمي
+
+154
+00:14:06,890 --> 00:14:10,410
+و إلا حيصير فيه ربع طبعا و هنحكي هذا بالتفصيل في
+
+155
+00:14:10,410 --> 00:14:15,730
+وقته لكن أجمالا الأن بس بدنا نعرف أن البيع اللي هو
+
+156
+00:14:15,730 --> 00:14:20,410
+بيع الصرف يشترط فيه القبض في المجلس إذا لا يصح فيه
+
+157
+00:14:20,410 --> 00:14:25,690
+خيار الشرط لأن خيار الشرط معناته ممكن ما أسلمكصح
+
+158
+00:14:25,690 --> 00:14:30,630
+ولا لأ؟ معناته ممكن ما أسلمك كونه إلي الخيار فإذا
+
+159
+00:14:30,630 --> 00:14:34,610
+صار في عندي مشكلة ممكن ربي يصير عندي في الموضوع
+
+160
+00:14:34,610 --> 00:14:39,830
+لذلك لا يصح هذا الشرط أو اشتراك هذا الخيار في مثل
+
+161
+00:14:39,830 --> 00:14:44,070
+هذا العقد نفس الشيء بيق الطعام بالطعام من الأموال
+
+162
+00:14:44,070 --> 00:14:48,350
+الربوية اللي هنتحدث عنها في وقتها الآن أبيق طعام
+
+163
+00:14:48,350 --> 00:14:53,060
+في زمن مافيش مشكلة أنه الزمن يتأجللكن أبيع الطعام
+
+164
+00:14:53,060 --> 00:14:57,780
+الطعام لازم يتم القبض في المجلس طالما أن القبض في
+
+165
+00:14:57,780 --> 00:15:03,300
+المجلس شرط لصحة العقد حينها لا يصح اشتراط خيار
+
+166
+00:15:03,300 --> 00:15:08,070
+الشرط الأمر التالت بيع السلامممكن تقولي لطب في
+
+167
+00:15:08,070 --> 00:15:11,270
+السلة ما هو المبيع مؤجل بقولك اه لكن الثمن لازم
+
+168
+00:15:11,270 --> 00:15:15,970
+يكون مُعَجَل لازم يندفع هيقبض في المجلس لازم ينقبض
+
+169
+00:15:15,970 --> 00:15:20,030
+في المجلس وكونوا ينقبض في المجلس يعني مابينفع يكون
+
+170
+00:15:20,030 --> 00:15:23,110
+فيه خيار الشرط لأن خيار الشرط معناته هيصير كل
+
+171
+00:15:23,110 --> 00:15:27,850
+الإيوادين مؤجل صح ولا لا؟ وهذا لا يصح فبالتالي لا
+
+172
+00:15:27,850 --> 00:15:32,210
+يصح خيار الشرط في البيع الذي يشترط فيه القبض في
+
+173
+00:15:32,210 --> 00:15:36,030
+المجلس علم؟ تمام؟ هذه النقطة الأولى النقطة التانية
+
+174
+00:15:42,270 --> 00:15:48,930
+يلا اتفضل اذا
+
+175
+00:15:48,930 --> 00:16:02,290
+لا يصح خيار الشرط الا في عقود المعاوضات وهذا يعني
+
+176
+00:16:02,290 --> 00:16:03,750
+انه في التبرعات
+
+177
+00:16:05,870 --> 00:16:10,830
+لا يصح اتخيلي انا بدي اجي اعطيك هدية و تقوليلي
+
+178
+00:16:10,830 --> 00:16:13,650
+بشرط ايه الخيار تلت أيام اقولك نعم يا ماما طب
+
+179
+00:16:13,650 --> 00:16:18,170
+هتيها صح ولا لا فمش منطق لأنه الخيار أصلا لدفع
+
+180
+00:16:18,170 --> 00:16:21,310
+الدرر عني طب انا ما أعطياكي هدية و انت مش هتعطيني
+
+181
+00:16:21,310 --> 00:16:25,050
+حجها على أي أساس نشترط الخيار في مثل هذا العقد
+
+182
+00:16:25,050 --> 00:16:30,090
+فإذا عقود التبرعات على اختلافها لا يصح فيها خيار
+
+183
+00:16:30,090 --> 00:16:35,430
+مش لا يشترط لا يصح فيها خيار الشرطفلحظى نرجع
+
+184
+00:16:35,430 --> 00:16:38,650
+للعبارة قلّك لا يصح خيار الشرط إلا في عقود
+
+185
+00:16:38,650 --> 00:16:42,970
+المعوضات، معناته يصح في عقود المعوضات، صح ولا لأ؟
+
+186
+00:16:42,970 --> 00:16:46,930
+والبيع قلنا من عقود المعوضات، لكن هل في جميع أنواع
+
+187
+00:16:46,930 --> 00:16:50,490
+البيوع قلنا يستثنى البيوع اللى اشترت فيها القبض في
+
+188
+00:16:50,490 --> 00:16:53,490
+مجلس العقد، صار واضح، اه؟ اذا لحظى واحد واتنين
+
+189
+00:16:53,490 --> 00:16:58,480
+مكملين لبعضوصلت؟ تمام عشان هيك لو جبتلك هي العبارة
+
+190
+00:16:58,480 --> 00:17:03,360
+لا يصح خيار الشرط إلا في عقود المعاوضات أو يصح في
+
+191
+00:17:03,360 --> 00:17:07,740
+عقود المعاوضات okay صح لكن قلتلك يصح خيار الشرط في
+
+192
+00:17:07,740 --> 00:17:13,020
+عقود المعاوضات مطلقا هتصير غلط لأنه البيع الذي
+
+193
+00:17:13,020 --> 00:17:16,740
+يشترط فيه القبض في المجلس من المعاوضات صح ولا لا؟
+
+194
+00:17:16,740 --> 00:17:21,320
+وهو لا يصح خيار الشرط لا يصح في البيع الذي يشترط
+
+195
+00:17:21,320 --> 00:17:26,990
+فيه القبض في المجلس وصلت الفكرة؟ تمامرقم تلاتة
+
+196
+00:17:26,990 --> 00:17:32,270
+جماعة
+
+197
+00:17:32,270 --> 00:17:40,470
+أي واحدة عندها سؤال عادي تسأل يعني المعوضات أي بيع
+
+198
+00:17:40,470 --> 00:17:46,340
+فيه بدلانأي عقد عفوًا، الآن الإجارة في مبادلة ولا
+
+199
+00:17:46,340 --> 00:17:51,960
+لأ؟ أه في مبادلة، في أجرة وفي منفع، صح ولا لأ؟ بس
+
+200
+00:17:51,960 --> 00:17:55,340
+هالجيتها نعرف إن الإجارة لأ، في إشي بخوف عليها،
+
+201
+00:17:55,340 --> 00:18:00,280
+لكن ابتداء معوضات كمعوضات الإجارة معوضات، البيع
+
+202
+00:18:00,280 --> 00:18:05,340
+معوضات، كل بيع أو كل عقد فيه عيوضين، يعني أنا وياك
+
+203
+00:18:05,340 --> 00:18:13,990
+بنعطيلكن غير المعاوضات حد بياخد والتاني ايش؟
+
+204
+00:18:13,990 --> 00:18:20,190
+بياخدش وصلت؟ تمام دائما من اسمها معاوض يعني في
+
+205
+00:18:20,190 --> 00:18:25,770
+عيوضين في عيوضين مبادلة يعني تمام؟ حلو رقم تلاتة
+
+206
+00:18:25,770 --> 00:18:26,170
+اتفضلي
+
+207
+00:18:30,530 --> 00:18:36,070
+أيوة لحظة هذه هتقولك ان في من المعاوضات كمان ايش
+
+208
+00:18:36,070 --> 00:18:40,650
+لا يصح فيها خيار الشرطة اه كاملة لا يصح العقود
+
+209
+00:18:40,650 --> 00:18:44,410
+الواردة على منفعة عقد النكاح وعقد الإجارة بارك
+
+210
+00:18:44,410 --> 00:18:48,750
+الله فيك اذا لا يصح خيار الشرط في العقود الواردة
+
+211
+00:18:48,750 --> 00:18:59,430
+على منفعة مثل عقد النكاح وعقد الإجارةالان عقد
+
+212
+00:18:59,430 --> 00:19:04,610
+النكاح يرد على منفع، تمام؟ فإذا لا يصح فيه خيار
+
+213
+00:19:04,610 --> 00:19:09,450
+الشرط، ما بيصير الأزواج يعقدوا العقد و أحدهم يشترط
+
+214
+00:19:09,450 --> 00:19:12,190
+على الآخر يقوله بشرط إيه الخيار تلت أيام، ماعجبنيش
+
+215
+00:19:12,190 --> 00:19:16,950
+بتدروا عند ماما، أقوله لأ يا ماماوصلات مش منطق
+
+216
+00:19:16,950 --> 00:19:20,850
+يعني، تمام؟ فإذا لا يصح خيار الشرط في مثل هذا
+
+217
+00:19:20,850 --> 00:19:26,770
+العقد، أيضا عقد الإجارة عقد الإجارة يا جماعة في
+
+218
+00:19:26,770 --> 00:19:31,290
+منفعة مقابلها أجرة، صح؟ طيب حلو، أنا الآن دفعت
+
+219
+00:19:31,290 --> 00:19:35,630
+أجرة مقابل سكن البيت لمدة شهر، أجي أقولك، بدي
+
+220
+00:19:35,630 --> 00:19:39,310
+أفترض أن الخيار بنفع خيار الشرط، أقولك إيه الخيار
+
+221
+00:19:39,310 --> 00:19:44,150
+تلت أيام، طب ما التلت أيام هدول أنا سكنت البيت؟صح
+
+222
+00:19:44,150 --> 00:19:48,990
+ولا لأ؟ فسكنة البيت هي فيه أجرة أن تأخذ مقابلها،
+
+223
+00:19:48,990 --> 00:19:53,630
+فإذا كيف بدي أسترد المنفع؟ المنفع لا تسترد، المنفع
+
+224
+00:19:53,630 --> 00:19:58,730
+تستهلك فلا تسترد، لما أتحدث عن سكنة البيت مدة شهر،
+
+225
+00:19:58,730 --> 00:20:01,790
+تلاتين يوم، طب أنا لما اشترت الخيار تلات أيام،
+
+226
+00:20:01,790 --> 00:20:06,340
+معناته أخدت منفعي تلاتة من تلاتينصح ولا لا؟ فإذا
+
+227
+00:20:06,340 --> 00:20:11,160
+لا يصح خيار الشرط في العقود التي ترد على المنفعة
+
+228
+00:20:11,160 --> 00:20:23,340
+مثل الإجارة و النكاح تمام نيجي للأمر الرابع فضل
+
+229
+00:20:23,340 --> 00:20:27,060
+بارك
+
+230
+00:20:27,060 --> 00:20:34,530
+الله فيك إذا رقم أربعة قالك لا يصح خيار الشرطفي
+
+231
+00:20:34,530 --> 00:20:41,630
+عقد حيلتين ليربح في قرضين خليكم معايا عشان نفهم شو
+
+232
+00:20:41,630 --> 00:20:46,770
+يعني عقد حيلة الان انا و انتي و كلنا بنعرف ان اخد
+
+233
+00:20:46,770 --> 00:20:51,430
+منك الف شاكل و ارجعلك الف و متين بنفعش ريبا كلنا
+
+234
+00:20:51,430 --> 00:20:55,480
+عارفين هذا الكلامفالان بدي أتهمك يا اسلام بعدم
+
+235
+00:20:55,480 --> 00:20:59,540
+النزاح اه ماعليش اتحملنا هلجيت انا و اسلام انا
+
+236
+00:20:59,540 --> 00:21:03,600
+الان محتاجة جدا ألف شكل ماعيش ولا شكل و انا محتاجة
+
+237
+00:21:03,600 --> 00:21:09,940
+كتير للفلوس هلجيت بدي أديان من اسلام و اسلامبتحب
+
+238
+00:21:09,940 --> 00:21:14,340
+تاخد زيادة يعني، لكن خلاص يعني بدها .. بدها تعمل
+
+239
+00:21:14,340 --> 00:21:17,860
+حالها إنه إنسانة وارعة ومابدهاش تاخد لا زيادة ولا
+
+240
+00:21:17,860 --> 00:21:22,320
+شي ولا أي حاجة، باعتبار هذا الإشي، بدي أفترض جدلا
+
+241
+00:21:22,320 --> 00:21:26,120
+إنه القانون بيحسب عليه، ضميرها ما حسبها، بس لإنه
+
+242
+00:21:26,120 --> 00:21:29,500
+في قانون بيدربها على إيدها فجالة، فبتقدرش إنها
+
+243
+00:21:29,500 --> 00:21:34,560
+تقولي بدي 1200، مثلافراحت بدها تاخد لزيادة بس إش
+
+244
+00:21:34,560 --> 00:21:39,840
+بطريقة ملتوية حيلة فإيش عملت؟ أنا الآن رقزوا معايا
+
+245
+00:21:39,840 --> 00:21:43,540
+عشان نفهمها صح أنا الآن هذا في إيش بدي؟ بدي ألف
+
+246
+00:21:43,540 --> 00:21:47,920
+شاكل صح ولا لأ؟ أنا محتاجة هذا الألف شاكل فراحت
+
+247
+00:21:47,920 --> 00:21:53,600
+إيش عملت؟ بعتني جوالها دان أنا مش بدي في الجوال
+
+248
+00:21:53,600 --> 00:21:57,240
+أصلا ماعيش ولا شاكل أدفعلها حاجة بعتلييا دان بألف
+
+249
+00:21:57,240 --> 00:22:04,400
+و متين شاكلبعتلي يدين ب1200 شكل صار في ذمتي جداش
+
+250
+00:22:04,400 --> 00:22:08,540
+لازم أدفع لها جداش 1200 شكل حاجة الجوال عادي هذه
+
+251
+00:22:08,540 --> 00:22:13,300
+الصورة مافيها أي مشكلة فبعد ما بعتني و تم البيع
+
+252
+00:22:13,300 --> 00:22:17,280
+بيني وبينها إجت تشتري الجوال مني ب1000 شكل دفعتلي
+
+253
+00:22:17,280 --> 00:22:21,310
+cash 1000 شكل و أخدت جوالهاهل جيت أنا صار بإيدي
+
+254
+00:22:21,310 --> 00:22:25,910
+ألف شكل ومطلوب مني إيش؟ أرجع ألف و متين فهذا
+
+255
+00:22:25,910 --> 00:22:29,590
+بنسميه بيع العينة العلماء تحدثوا عنه اسمه بيع
+
+256
+00:22:29,590 --> 00:22:37,210
+العينة وهذا بيع محرم لأنه إيش؟ لشبهة الربا، تمام
+
+257
+00:22:37,210 --> 00:22:42,470
+وصلت؟ فالآن أن أشترط الخيار في مثل هذا البيع طبعا
+
+258
+00:22:42,470 --> 00:22:46,350
+ما بصح لأنه هيك هيك هيكون مفاده ربح في قرض
+
+259
+00:22:46,350 --> 00:22:52,350
+وبالتالي ما بصح علم؟تمام؟ طيب نيجي للنقطة الأخيرة
+
+260
+00:22:52,350 --> 00:22:55,410
+سؤال؟
+
+261
+00:22:55,410 --> 00:22:59,830
+في أي سؤال يا جماعة؟ تمام
+
+262
+00:23:08,360 --> 00:23:13,220
+برك الله فيك إذا خيار الشرط بدنا نركز في هذه
+
+263
+00:23:13,220 --> 00:23:17,120
+الإبارة لإن هذه الإبارة ممكن أعبر عنها بأربع صياغ
+
+264
+00:23:17,120 --> 00:23:21,340
+و تكون نفسها هي هي نفس المعنى يعني تمام؟ و هذا
+
+265
+00:23:21,340 --> 00:23:27,520
+معناته دائما بنبهك إنك ماتحفظيش افهمي أهم شئ لإن
+
+266
+00:23:27,520 --> 00:23:32,320
+هذه الإبارة انت ممكن تعبريلي عنها بأربع صياغ و
+
+267
+00:23:32,320 --> 00:23:35,920
+كلها نفس المعنى تمام؟ إيش هي؟ الإبارة الكتاب
+
+268
+00:23:35,920 --> 00:23:47,200
+ابتدائا قالك لا يا صاحخيار الشرط فيما لا يحتاج في
+
+269
+00:23:47,200 --> 00:24:01,420
+فسخه إلى إرادة العاقدين بل ينفسخ بإرادة
+
+270
+00:24:04,380 --> 00:24:08,360
+واحدة خلّيكوا معايا إيش معنى هذه الإبارة؟ قال لك
+
+271
+00:24:08,360 --> 00:24:13,130
+ما بصحفيما لا يحتاج .. إيش هو اللي لا يحتاج في
+
+272
+00:24:13,130 --> 00:24:15,890
+فسخه إلى إيرادة المتعاقدة؟ إن العقود غير اللازمة
+
+273
+00:24:15,890 --> 00:24:20,190
+عقود غير اللازمة صح ولا لا؟ العقود غير اللازمة هي
+
+274
+00:24:20,190 --> 00:24:24,150
+التي لا تحتاج في فسخها إلى إيرادة الطرفين بل تنفسخ
+
+275
+00:24:24,150 --> 00:24:29,370
+بإيرادة واحدة مش هذا هو العقد غير اللازم؟ حلو إذن
+
+276
+00:24:29,370 --> 00:24:34,290
+سواء جبتلك هذه الإبارة أو قلتلك لا يصح خيار الشرط
+
+277
+00:24:34,290 --> 00:24:39,620
+في العقود غير اللازمة نفس المعنىنفس المعنى طب
+
+278
+00:24:39,620 --> 00:24:43,740
+أجيبلك كمان معنى تالت أو صيغة تالتة لنفس المعنى
+
+279
+00:24:43,740 --> 00:24:51,320
+أجي أقولك يصح .. يصح شيلي لا يصح خيار الشرط فيما
+
+280
+00:24:51,320 --> 00:24:59,980
+يحتاج إلى إرادة المتعاقدين لفسخه طبعا صح ما هي نفس
+
+281
+00:24:59,980 --> 00:25:04,990
+المعنى لا يصح في كذا يعني يصح في العكسصح ولا لأ؟
+
+282
+00:25:04,990 --> 00:25:10,870
+فإذا يصح خيار المجلس في العقود التي تحتاج إلى
+
+283
+00:25:10,870 --> 00:25:15,770
+إيرادة المتعاقدين لفسخها ولا تنفسخ بإيرادة منفردة
+
+284
+00:25:15,770 --> 00:25:22,290
+وهذا يعني الأمر الرابع أن خيار المجلس يصح في
+
+285
+00:25:22,290 --> 00:25:25,850
+العقود اللازمة عفوا خيار الشرط يصح في العقود
+
+286
+00:25:25,850 --> 00:25:31,790
+اللازمة تمام؟ واضح؟معلنة كده من بالمين واضح كلامي
+
+287
+00:25:31,790 --> 00:25:35,490
+أنا حساه يعني مش عارفة وين ال trick اللي عندكم كده
+
+288
+00:25:35,490 --> 00:25:41,770
+عاملين في أي سؤال؟
+
+289
+00:25:41,770 --> 00:25:48,090
+إيش قاعد .. قاعدوا كلهم الأربعة؟ okay hell gate
+
+290
+00:25:49,330 --> 00:25:53,750
+جماعة عشان كده بتدرجة أؤكدش نفس الشغلة، ما تحفظيش،
+
+291
+00:25:53,750 --> 00:25:57,010
+افهم الفكرة و عبري عنها لحالك، هتصبح سهلة، لأن
+
+292
+00:25:57,010 --> 00:26:02,370
+احنا بنقول خيار الشرط لا يصح في العقود اللي
+
+293
+00:26:02,370 --> 00:26:08,680
+مابتحتاجش للإيرادتين حتى تنفسخيعني بالصح في العقود
+
+294
+00:26:08,680 --> 00:26:13,880
+اللي بتحتاج للإيرادتين حتى تنفسخ يعني بصحش في
+
+295
+00:26:13,880 --> 00:26:19,360
+العقود غير اللازمة يعني بصح في العقود اللازمة
+
+296
+00:26:19,360 --> 00:26:26,400
+that's only في أي سؤال؟ أي سؤال؟ طيب النقطة
+
+297
+00:26:26,400 --> 00:26:31,880
+الأخيرة في محاضرتنا قبل أن نختمها لمن يثبت خيار
+
+298
+00:26:32,950 --> 00:26:39,650
+الشرط لحظة معايا نرجع للتعريف التعريف شو بيقول حق
+
+299
+00:26:39,650 --> 00:26:45,910
+يثبت لمن اشترته إذا يثبت هذا الخيار للذي اشترته
+
+300
+00:26:45,910 --> 00:26:50,890
+سواء أكان هو البائع أو المشتري أو كليهما أو أجنبي
+
+301
+00:26:52,420 --> 00:26:57,400
+فمن اشترط الخيار لنفسه طبعا له الحق في الإمضاء أو
+
+302
+00:26:57,400 --> 00:27:03,200
+الفسخ لكن خلال مدة الخيار المتفق عليها بينهما
+
+303
+00:27:03,200 --> 00:27:09,220
+تمام؟ وبناء على ذلك لو أن البائع هو الذي اختار
+
+304
+00:27:10,430 --> 00:27:13,590
+الخيار لنفسه ممكن واحدة تقول لي ما هو مش منطقي
+
+305
+00:27:13,590 --> 00:27:17,230
+البيع هو اللي يختار يعني انتوا دايما بتتصوروا ان
+
+306
+00:27:17,230 --> 00:27:22,370
+الدرر قد يلحق المشتري فيشترت كي لا يتضرر لأ مش
+
+307
+00:27:22,370 --> 00:27:26,530
+دايما ممكن انا كبيع برضه من البيع اتضرر فاشترت
+
+308
+00:27:26,530 --> 00:27:29,410
+الخيار لنفسي يعني مثلا اجيبلك مثال بسيط عشان
+
+309
+00:27:29,410 --> 00:27:36,910
+تتصوريها يعنى بدي اقولك انا الآن مضطرة لسبب ماإني
+
+310
+00:27:36,910 --> 00:27:39,910
+أبيح سيارتي أنا مابدي أبيحها أبدا و مش حاب أبدا
+
+311
+00:27:39,910 --> 00:27:44,410
+أبيحها لكن محتاج لفلوس ضروري جدا جدا جدا علي
+
+312
+00:27:44,410 --> 00:27:50,430
+الاتزام بده فلوس و لازم و مافيش حد بديني مثلاف ..
+
+313
+00:27:50,430 --> 00:27:54,190
+و في انا اصلا مثلا بدي فلوس من ناس و الناس
+
+314
+00:27:54,190 --> 00:27:57,230
+ماجابولي الفلوس بس في احتمال يشبوها خلال يومين
+
+315
+00:27:57,230 --> 00:28:01,130
+برضه مش متأكدة فانا روحت .. بدي المبلغ اليوم ضروري
+
+316
+00:28:01,130 --> 00:28:06,270
+فروحت باعتها و اشترت الخيار لنفسي قولت انه الي
+
+317
+00:28:06,270 --> 00:28:11,950
+الخيار تلت أيام مثلا اني ممكن اتراجعبنفع؟ أه بنفع
+
+318
+00:28:11,950 --> 00:28:17,690
+لأنه أنا بيعي كان اضطرارا ربما فأنا يعني ممكن
+
+319
+00:28:17,690 --> 00:28:23,150
+البيع يسببلي ضرر فعشان كده مثلا و ممكن أحيانا
+
+320
+00:28:23,150 --> 00:28:29,090
+اشتراتي انا كبيع للخيار لإني أصلا بجهل الثمن بعرفش
+
+321
+00:28:29,090 --> 00:28:32,470
+بجد أمش بتنبع هنا بالسوق مثلا و أنا خفت تكونوا
+
+322
+00:28:32,470 --> 00:28:35,170
+بتضحكوا عليا لما قلتلك بدي أبيعك زي ما بتشتريها من
+
+323
+00:28:35,170 --> 00:28:38,590
+فلان و أنت قلتيلي أنا بشتريها ب1000 شكل أي شغلة
+
+324
+00:28:38,590 --> 00:28:43,460
+بغض النظر شهية مش سيارةفالان و انا بناء انا على
+
+325
+00:28:43,460 --> 00:28:47,060
+امانتك بعتك بس قلتلك ايه الخيار حجي ولا مش حجي؟ اه
+
+326
+00:28:47,060 --> 00:28:51,540
+حجي طب انا بدي اسأل برضه بدي اسأل لان برضه okay
+
+327
+00:28:51,540 --> 00:28:55,240
+انا مش عارف السعر لكن في نفس الوقت انا مش اهبل
+
+328
+00:28:55,240 --> 00:28:59,440
+برضه مثلا صح ولا لا؟فاذا برضه يا حق ليه الخيار
+
+329
+00:28:59,440 --> 00:29:03,580
+فسواء انا او انتي او حتى كمان اي حد فينا بيقدر
+
+330
+00:29:03,580 --> 00:29:06,980
+يشترط الخيار لطرف أجنبي تالت يعني لا بائع ولا
+
+331
+00:29:06,980 --> 00:29:12,060
+مشتري يعني عادي جدا اشتري منك جوال و اقولك و لأخي
+
+332
+00:29:12,060 --> 00:29:15,480
+الخيار ثلاثة أيام شو علاقة أخوكي مش بائع ولا مشتري
+
+333
+00:29:15,480 --> 00:29:19,380
+ابقى أقولك أه بنفع لأنه مش احنا قلنا في مشروعيته
+
+334
+00:29:19,380 --> 00:29:25,710
+انه ممكن انا اشترطه لجل استشير أهل الخبرةفانا ممكن
+
+335
+00:29:25,710 --> 00:29:29,730
+حتى لو أخدت الخيار لنفسي مااستفيدش، ضلوا إني و
+
+336
+00:29:29,730 --> 00:29:32,290
+مين، طب و أنا والله مانا فاهم، هيني بفتح و كذا، مش
+
+337
+00:29:32,290 --> 00:29:35,450
+عارفة أصلا ال option اللي فيه منيحة مش منيحة،
+
+338
+00:29:35,450 --> 00:29:39,790
+بيصير شو، بعرفش، فأنا اشترته لحدا بيفهم، بنفع؟ أه
+
+339
+00:29:39,790 --> 00:29:45,490
+بنفع، علم؟ تمام، هذا بالنسبة لموضوع محاضرتنا لهذا
+
+340
+00:29:45,490 --> 00:29:46,730
+اليوم، تفضلي سؤالك
+
+341
+00:29:51,570 --> 00:29:55,070
+بده again حاجة تقيلها على امان مثلا لما تقابلها زي
+
+342
+00:29:55,070 --> 00:29:57,970
+ما بنلعب على الرابط هو بيعرف مشكلته و اذا كنت اللي
+
+343
+00:29:57,970 --> 00:30:03,380
+بيبقى مشتاقين هو بتكون بده حلوةأه طبعا و هناخد هذا
+
+344
+00:30:03,380 --> 00:30:07,000
+الكلام في بيوع الخاصة هنتحدث و أنا أدتكم إشارة
+
+345
+00:30:07,000 --> 00:30:10,160
+لهذا الموضوع أصلا يعني أعطيتكم إشارة لكن هنفصلوا
+
+346
+00:30:10,160 --> 00:30:14,140
+في وقته ان شاء الله طيب هذا ما يتعلق بموضوع
+
+347
+00:30:14,140 --> 00:30:19,620
+محاضرتنا لهذا اليوم المحاضرة القادمة نكمل ما يتعلق
+
+348
+00:30:19,620 --> 00:30:23,800
+بخيار الشرط من أحكام أقول قول هذا و أستغفر الله لي
+
+349
+00:30:23,800 --> 00:30:27,620
+ولكم و صلى اللهم و السلم وبارك على سيدنا محمد
+
+350
+00:30:27,620 --> 00:30:30,100
+والسلام عليكم ورحمة الله تعالى
+
diff --git a/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/9mnn_AoiL3I_raw.srt b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/9mnn_AoiL3I_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b54aa647d50054780441c40d25e46ea472902b68
--- /dev/null
+++ b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/9mnn_AoiL3I_raw.srt
@@ -0,0 +1,1760 @@
+1
+00:00:05,960 --> 00:00:08,980
+اعودوا بالله السامع لعليه من الشيطان الرجيم بسم
+
+2
+00:00:08,980 --> 00:00:12,780
+الله الرحمن الرحيم الحمد لله رب العالمين والصلاة
+
+3
+00:00:12,780 --> 00:00:16,260
+والسلام على أشرف الأنبياء والمرسلين سيدنا محمد بن
+
+4
+00:00:16,260 --> 00:00:20,180
+عبدالله الصادق الأمين ثم أما بعد أحييكم جميعا
+
+5
+00:00:20,180 --> 00:00:23,620
+بتحية الإسلام في السلام عليكم ورحمة الله تعالى
+
+6
+00:00:23,620 --> 00:00:28,880
+وبركاته كيف حالكون طيبات ان شاء الله تحضيرنا جيد
+
+7
+00:00:28,880 --> 00:00:34,730
+ان شاء اللهطب عظيم إذا المحاضرة السابقة كنا قد
+
+8
+00:00:34,730 --> 00:00:39,010
+انتهينا من الحديث عما يتعلق بالقسم الأول من أقسام
+
+9
+00:00:39,010 --> 00:00:43,970
+البيوع المنهي عنها ألا وهو البيوع الباطلة وقولنا
+
+10
+00:00:43,970 --> 00:00:49,530
+إن هذه البيوع تعد محرمة إضافة إلى أنها إذا وقعت لا
+
+11
+00:00:49,530 --> 00:00:54,440
+يترتب عليها أي أثر من أثار عقد البيع لأنها تحتبتوي
+
+12
+00:00:54,440 --> 00:00:58,680
+على خلل إما في أركانها أو في شروطها وسبق أن
+
+13
+00:00:58,680 --> 00:01:05,180
+تناولناها تفصيلا ولا داعي للتذكير بها اليوم بإذن
+
+14
+00:01:05,180 --> 00:01:08,780
+الله سنتحدث عن القسم التاني من أقسام البيوع المنهي
+
+15
+00:01:08,780 --> 00:01:14,340
+عنها اللي هو البيوع الصحيحة غير الباطلة وحينما
+
+16
+00:01:14,340 --> 00:01:19,240
+أقول إن هذه البيوع رغم كونها غير باطلة منهي عنها
+
+17
+00:01:19,600 --> 00:01:26,740
+هذا يعني أن فاعلها يعد آثما وأيضا هذا يعني أن سبب
+
+18
+00:01:26,740 --> 00:01:32,520
+النهي عنها لا يرجع إلى خلل في أركانها أو شروطها بل
+
+19
+00:01:32,520 --> 00:01:38,720
+يرجع إلى وصف خارج عن ما هي العقد كأن يكون فيه
+
+20
+00:01:38,720 --> 00:01:42,800
+تضييق على الناس أو إضرار بالغير وغير ذلك من الأمور
+
+21
+00:01:42,800 --> 00:01:49,520
+التي ستظهر وتتضح معنا خلال دراستنالجملة من البيوع
+
+22
+00:01:49,520 --> 00:01:56,240
+الصحيحة أول هذه هي البيوع بيع الحاضر للبادي مين
+
+23
+00:01:56,240 --> 00:02:05,980
+يتحدثنا عن هذا البيع؟ بيع الحاضر للبادي تفضلي
+
+24
+00:02:05,980 --> 00:02:12,080
+هو الحاضر هو سكن القدرة أي المدينة أو القرية
+
+25
+00:02:15,120 --> 00:02:18,940
+بارك الله فيك اذا الحاضر والبادي شخصين واحد بيسكن
+
+26
+00:02:18,940 --> 00:02:22,500
+المدينة والتاني بيسكن البادية اي الصحراء طبعا
+
+27
+00:02:22,500 --> 00:02:28,440
+فالان كيف بنتحدث عن بي حاضر لبادي المسألة طبعا
+
+28
+00:02:28,440 --> 00:02:32,780
+دائما بالمثال يتضح المقال ودائما قاتى بامثلة
+
+29
+00:02:32,780 --> 00:02:37,260
+افتراضية مش ضرورى تكون منطقية او صحيحة بقدر ما
+
+30
+00:02:37,260 --> 00:02:41,420
+انها توصل الفكرة اللى بنحكى فيهاوبنان على ذلك، بدي
+
+31
+00:02:41,420 --> 00:02:46,140
+أفترض في عندي حدا جايلي من صحراء سيناء جاي وين هنا
+
+32
+00:02:46,140 --> 00:02:54,460
+على غزة، تمام؟ وهذا الشخص البادي،
+
+33
+00:02:54,460 --> 00:02:59,000
+اللحظة قولت غزة عشان نقول حاضر يعني، فهان، حاضر،
+
+34
+00:02:59,000 --> 00:03:06,270
+حلو، فهذا الشخص اللي جاي من الباديةجاي ومعاه محملا
+
+35
+00:03:06,270 --> 00:03:12,750
+بضائع تعوم حاجة ناس أهل غزة بها، يعني أهل غزة مثلا
+
+36
+00:03:12,750 --> 00:03:15,910
+بدي أفطر الجدلان اليوم، الغاز الطهي مش موجود في
+
+37
+00:03:15,910 --> 00:03:21,220
+غزة، بدنا نفطر اليوماللي من البادية سمع انه والله
+
+38
+00:03:21,220 --> 00:03:24,920
+مافيش غاز في غزة فجالك يلا فرصة انا بروح اتاجر و
+
+39
+00:03:24,920 --> 00:03:28,500
+ببيع عندهم طبعا هو لا قصد ينتهزنا ولا يستغلنا ولا
+
+40
+00:03:28,500 --> 00:03:32,320
+اي شيء ايجا بس انه عادي كتاجر طبيعي دائما التجار
+
+41
+00:03:32,320 --> 00:03:35,320
+بيدوروا وين فيه طلب على السلاع تبعتهم بيروحوا
+
+42
+00:03:35,320 --> 00:03:39,760
+يبيعوها مافي مشكلة فهو جاي على هذا الأساس جاي معاه
+
+43
+00:03:39,760 --> 00:03:43,940
+غزطهي لحظة انا قولت غزطهي باعتبار بدي اقول شغلة
+
+44
+00:03:43,940 --> 00:03:49,880
+الناس محتاجها مش اشيلا يحتاجون إليها يعني في غين
+
+45
+00:03:49,880 --> 00:03:54,800
+عنها مثلا لأ فهو جاي معاه غزطهي بده يبيعه هنا في
+
+46
+00:03:54,800 --> 00:04:02,430
+غزةهل جدفش في راسه انه يحتكر ولا يخبي ولا يغلي ولا
+
+47
+00:04:02,430 --> 00:04:05,730
+اي شي عادي بدي ابيع عادي مثله مثل اي تاجر هيك حاطت
+
+48
+00:04:05,730 --> 00:04:10,330
+في راسه الا النشمي الغزاوي ما شاء الله تبارك الله
+
+49
+00:04:10,330 --> 00:04:15,110
+بدي حقق مصلحته للبادي و بدي اضرب اهل بلده فإيش
+
+50
+00:04:15,110 --> 00:04:20,030
+عمل؟ قال له طب شو رأيك تخلي الموضوع عليا و انا
+
+51
+00:04:20,030 --> 00:04:24,870
+بخبيلك اياهم عندى بالمخازن؟و ببيعلك إياهم على
+
+52
+00:04:24,870 --> 00:04:29,110
+التدريج كل يوم بطلقلك أكم من سوانة غاز بأعلى من
+
+53
+00:04:29,110 --> 00:04:32,590
+السعر اليوم لأن الناس كونوا مش موجودة في السوق
+
+54
+00:04:32,590 --> 00:04:37,050
+هتلاقي إنها مضطرة تشتري بالسعر الغالي هذا فالموضوع
+
+55
+00:04:37,050 --> 00:04:42,180
+عندي شو رأيك؟بالتأكيد البادى هيكيف ليش؟ لأنه
+
+56
+00:04:42,180 --> 00:04:46,020
+منطقيا دائما دائما المعادلة بتقول أن البائع يريد
+
+57
+00:04:46,020 --> 00:04:48,920
+أن يبيع بأعلى الأثمان والمشتري يريد أن يشتري بيه
+
+58
+00:04:48,920 --> 00:04:53,180
+أقل الأثمان وبالتالي منطقيا أن مصلحة البادى أن
+
+59
+00:04:53,180 --> 00:04:58,660
+تباع بهذا العرض اللي عرضه عليه الحاضر وبالتالي
+
+60
+00:04:58,660 --> 00:05:03,900
+مافي أسم أبدا على البادى عادي جدالكن الإثم على
+
+61
+00:05:03,900 --> 00:05:10,560
+الحاضر ولحظي هنا في هذه الحالة إنه ماكانش لأنه في
+
+62
+00:05:10,560 --> 00:05:14,440
+خلل في الشروط في أركان البيع صحيح مية بالمية لكن
+
+63
+00:05:14,440 --> 00:05:19,100
+الخلل برجع لوصف خارج عن البيع اللي هو الإضرار
+
+64
+00:05:19,100 --> 00:05:23,940
+بالناس التضييق على الناس تضييق الحاضر بأهل بلده
+
+65
+00:05:23,940 --> 00:05:29,820
+بالناس بالمشترين لذا كان هذا إنه من هنا قال نبينا
+
+66
+00:05:29,820 --> 00:05:38,030
+صلى الله عليه وسلملا يبيع الحاضر ليه؟ بادي فهذا
+
+67
+00:05:38,030 --> 00:05:42,230
+دليل واضح على حرمة هذا البيأ والاسم يكون على
+
+68
+00:05:42,230 --> 00:05:46,870
+الحاضر وليس على البادي فلحظي معايا هنا بدي أقول
+
+69
+00:05:46,870 --> 00:05:54,470
+بأن هذا البيأ حتى نقول إنه حرام لابد من توفر ثلاثة
+
+70
+00:05:54,470 --> 00:06:01,570
+شروطينأول شيء أن تكون السلعة التي جاء بها البادي
+
+71
+00:06:01,570 --> 00:06:06,390
+مما تعوم بيه حاجة الناس وبالتالي على طول بدي أنفي
+
+72
+00:06:06,390 --> 00:06:10,730
+هذه الصورة عساس أقول أن وقتها مش هيكون حرام إذا
+
+73
+00:06:10,730 --> 00:06:14,930
+هذا البادي اللي جاي من الصحراء جاي بالنا container
+
+74
+00:06:14,930 --> 00:06:19,350
+ملابس اليوم أهل غزة عندهم ملابس بكفي تلت جيال جاية
+
+75
+00:06:20,410 --> 00:06:24,670
+مثلا فبالتالي هم مش محتاجين ملابس بمعنى لو اتخبط
+
+76
+00:06:24,670 --> 00:06:30,110
+عنهم و اتغلط عليهم مش راح يتضرروا حلو؟ وبالتالي في
+
+77
+00:06:30,110 --> 00:06:33,750
+هذه الحالة حتى لو ال body إيجي .. الحاضر عفوا إيجي
+
+78
+00:06:33,750 --> 00:06:36,510
+يقول لل body أنا بخليهم عندي و بخبيهم و ببيهم على
+
+79
+00:06:36,510 --> 00:06:39,070
+التدريج بأعلى من سعريهم مافيش أثام و مافيش حرمة و
+
+80
+00:06:39,070 --> 00:06:43,480
+مافيش أي مشكلةليش؟ لأن شرط الأثم والحرم فيه تضييق
+
+81
+00:06:43,480 --> 00:06:46,140
+على الناس، أمتى التضييق إذا السلعة مما تعوم بيها
+
+82
+00:06:46,140 --> 00:06:51,320
+الحاجة؟ حلو؟ واضح؟ تمام، هذا واحد إذا نرجع نقول
+
+83
+00:06:51,320 --> 00:06:57,320
+بأن هذا البي يؤد حرام رغم كونه صحيح، رغم كونه صحيح
+
+84
+00:06:57,320 --> 00:07:03,180
+إلا أنه محرم إذا كانت السلعة مما تعوم بيها الحاجة
+
+85
+00:07:05,430 --> 00:07:11,590
+كان الحاضر لا يقصد بيع هخليكي معايا حتى نقول انه
+
+86
+00:07:11,590 --> 00:07:17,630
+في أثم على الحاضر لازم البادى مايكونش قاصد البيع
+
+87
+00:07:17,630 --> 00:07:26,510
+بالتدريج مايكونش قاصد البيع بالتدريج فيطلب الحاضر
+
+88
+00:07:26,510 --> 00:07:33,020
+البيع بالتدريج و بأغلى من سعر اليوم يعنياليوم هذا
+
+89
+00:07:33,020 --> 00:07:35,940
+اللي زي ما قلنا قبل شوية اللي جاي من البادية جاي
+
+90
+00:07:35,940 --> 00:07:38,740
+يبيع ولا في باله لا يدور بينا ولا أي شيء و بدي
+
+91
+00:07:38,740 --> 00:07:42,820
+أبيعها عادي و بدي أروح على بلده فاللغزاوي جاله أنا
+
+92
+00:07:42,820 --> 00:07:49,700
+ببيعلك هان بصير في أثم على الحاضر لكن لو أصلا هان
+
+93
+00:07:49,700 --> 00:07:56,380
+نخلي الشرط اختلفلو نفترض إنه هو جاي و حاطط في راسه
+
+94
+00:07:56,380 --> 00:08:00,820
+إنه أنا بدي أروح أتاجر و أربح و أخبيها بالتدريج كل
+
+95
+00:08:00,820 --> 00:08:05,360
+أسبوع بطلعلي أكام من سوانة غاز و ببيعهم ففي هذه
+
+96
+00:08:05,360 --> 00:08:09,220
+الحالة هل يأثم أو خليني أقول قبل ما نقول هل يأثم
+
+97
+00:08:09,220 --> 00:08:15,250
+هو إجا و حاطط في راسه هذا الإشيفوطلبه كمان مش بس
+
+98
+00:08:15,250 --> 00:08:19,070
+حاطس في راسه طلبه من الحاضر أن يبيع إليه بالتدريج
+
+99
+00:08:19,070 --> 00:08:23,990
+هل هناك إثم على الحاضر بالتأكيد لأ فاش إثم على لا
+
+100
+00:08:23,990 --> 00:08:29,890
+هد ولا على هد خليني معايا مافي إثم وهذا لا يعد في
+
+101
+00:08:29,890 --> 00:08:36,840
+هذه الصورة من البيوع المنهي عنها الأن أنا كباديأنا
+
+102
+00:08:36,840 --> 00:08:42,400
+كبائع جاي أبيع من مكان لمكان، و أنا بدي أربح، أنا
+
+103
+00:08:42,400 --> 00:08:46,140
+جاي بدي أربح لأنه لغاية الصارعنة بصينة بعشرة جنيه
+
+104
+00:08:46,140 --> 00:08:48,960
+ولا بعشرين جنيه، يعني لا بربح ولا شيء، فجولت في
+
+105
+00:08:48,960 --> 00:08:54,110
+غزة بدي أربحالآن في أي مشكلة لأي تاجر يروح يتنقل
+
+106
+00:08:54,110 --> 00:08:58,150
+من مكان لآخر ويبيع بسعر أعلى، مافي أي مشكلة، فأنا
+
+107
+00:08:58,150 --> 00:09:01,110
+مابضربك على إيدك، يا بتشتري مني يا مابتشتري مني،
+
+108
+00:09:01,110 --> 00:09:06,690
+عادة، لكن الإشكالية في الحاضر اللي أراد أن يضرب
+
+109
+00:09:06,690 --> 00:09:10,870
+الناس من تلقائي نفسه، لأنه بدي أصير و كأنه هو من
+
+110
+00:09:10,870 --> 00:09:15,740
+أرشد غيره للإضرار بالناسفتكون الإثم أو تكون الحرمة
+
+111
+00:09:15,740 --> 00:09:20,920
+بينما فيما لو كان الذي طلب من الحاضر أن يبيع
+
+112
+00:09:20,920 --> 00:09:25,500
+بالتدريج هو البادي أصلا فلا إثمة على الحاضر ونفس
+
+113
+00:09:25,500 --> 00:09:31,840
+الأمر يقال فيما لو كان البادي كان قد قصده البيع
+
+114
+00:09:31,840 --> 00:09:37,820
+بالتدريج فبادره الحاضر وقال له أنا ببيعلكفي أثم
+
+115
+00:09:37,820 --> 00:09:42,180
+عليه؟ لأ ليش؟ لأن هو جاله أنا ببيعلك زي ما بدك
+
+116
+00:09:42,180 --> 00:09:45,760
+يعني مش أنا اللي قلتلك بيعمل تدريج هو بده فانا روح
+
+117
+00:09:45,760 --> 00:09:50,600
+اتعرضت الخدمات عليه في مشكلة برضه مافي مشكلة الأمر
+
+118
+00:09:50,600 --> 00:09:56,240
+الأخير طب ماذا لو ان .. لو أن البادي جاء ليبيع
+
+119
+00:09:56,240 --> 00:10:00,920
+السلع بثمن مثلها حالا يعني بدون لتدريج ولا شيء و
+
+120
+00:10:00,920 --> 00:10:06,130
+بتبيعها زي ما بتنبع عندنا هنا في غزةفإجى الغزاوي
+
+121
+00:10:06,130 --> 00:10:11,970
+الحاضر قال خليني أنا أبيعلك إياها، في مشكلة؟ مافيش
+
+122
+00:10:11,970 --> 00:10:15,550
+مشكلة بسعر يومها، مافي أي مشكلة في هذه الحالة،
+
+123
+00:10:15,550 --> 00:10:21,350
+واضح؟ تمام؟ إذا إذا كانت السلعة لا تقم بها حاجة
+
+124
+00:10:21,350 --> 00:10:25,170
+الناس، ركزوا معايا، لا تقم بها حاجة الناس
+
+125
+00:10:27,770 --> 00:10:33,390
+وقصبه البادى بيعها بأعلى من سعر يومها أو بالتدريج
+
+126
+00:10:33,390 --> 00:10:37,490
+فلا أثمة على الحاضر نفس الأمر يقال فيما لو كان
+
+127
+00:10:37,490 --> 00:10:41,170
+الذي طلب من الحاضر هو البادى برضه مافي أثمة على
+
+128
+00:10:41,170 --> 00:10:44,950
+الحاضر الأمر الأخير فيما لو أراد البادى أن يبيعها
+
+129
+00:10:44,950 --> 00:10:51,090
+بسعر يومها فطلب الحاضر أن يبيعها له بهذا السعرففي
+
+130
+00:10:51,090 --> 00:10:56,330
+هذه الحالة تنتفي الحرمة ويبقى البي الصحيح بالإضافة
+
+131
+00:10:56,330 --> 00:11:03,010
+إلى جوازه بمعنى عدم حرمته تمام نجي لتلقي الرقبة
+
+132
+00:11:03,010 --> 00:11:07,290
+نعم نجي لتلقي الرقبة
+
+133
+00:11:20,210 --> 00:11:27,130
+أه قبل التلقيه قضية حكم إرشاد الحاضر للبادي فيما
+
+134
+00:11:27,130 --> 00:11:33,490
+لو طلب منه استشارة يعني الآن جاي حدا نيجي للفث
+
+135
+00:11:33,490 --> 00:11:39,070
+المثال حدا من البادية جاي هنا لأهل لغزة يبيع سلعه
+
+136
+00:11:39,070 --> 00:11:43,730
+فإيجى ده شافله واحد غزاوي فجاله بدي أسألك سؤال
+
+137
+00:11:43,730 --> 00:11:49,200
+يعامر جاله اتفضل جاله شو رأيك أبيع السلعةاليوم مرة
+
+138
+00:11:49,200 --> 00:11:53,320
+واحدة ولا أبيعها على مراحل على دفعات؟ إيش رأيك في
+
+139
+00:11:53,320 --> 00:11:56,940
+الموضوع؟ إيش الأفضل؟ إيش الأفضل لإلي؟ إيش اللي
+
+140
+00:11:56,940 --> 00:12:02,420
+بيحققلي مكاسب أكتر؟ فطلب لحظي البادي بيسألني
+
+141
+00:12:02,420 --> 00:12:06,720
+باستشيرني أشير عليه إيش الأفضل هاد ولا هاد؟ شو
+
+142
+00:12:06,720 --> 00:12:11,340
+رأيكم؟ إيش الحكم؟ أشيره؟ أرشده؟ ولا ما أرشدوش؟
+
+143
+00:12:11,340 --> 00:12:15,790
+باعتبار إرشاده في تضييق على الناسلأنه مش هو طلب
+
+144
+00:12:15,790 --> 00:12:19,790
+مني نصيحة، النصيحة أقوله بالتدريج عشان يربح، صح
+
+145
+00:12:19,790 --> 00:12:25,810
+ولا لأ؟ فيا ترى أحكيله ولا ما أحكيلوش، تمام؟ وصلت
+
+146
+00:12:25,810 --> 00:12:29,750
+الصورة؟ فنقول العلماء اختلفوا في ذلك على قولين،
+
+147
+00:12:29,750 --> 00:12:37,080
+الأول منهما وهو الأصحأنه يجب على الحاضر أن يشهد
+
+148
+00:12:37,080 --> 00:12:40,860
+البادي يجب طب في تضييق عن الناس بقولك أه في تضييق
+
+149
+00:12:40,860 --> 00:12:45,560
+عن الناس لكن حق المسلم على المسلم صدق كما قال
+
+150
+00:12:45,560 --> 00:12:51,020
+نبينا صلى الله عليه وسلم ومن ذلك إذا استنصحه نصحه
+
+151
+00:12:51,020 --> 00:12:55,320
+النصيحة واجبة إذا حد طلب منك نصيحة انت ابدا مش
+
+152
+00:12:55,320 --> 00:13:00,930
+مطلب تنصحيني لكن أنا طلبت منك فصار يجب عليكيان
+
+153
+00:13:00,930 --> 00:13:04,390
+تقدمي .. لأ مافيه أبدا إثارة تمام؟ هذا القول الأول
+
+154
+00:13:04,390 --> 00:13:11,630
+وهو الراجح هو مش حرام بالدليل أصلا إذا هو جاي ..
+
+155
+00:13:11,630 --> 00:13:16,050
+إذا هو جاي وحاطط في راسه يبيع .. في مشكلة فيش
+
+156
+00:13:16,050 --> 00:13:20,450
+مشكلة لأ مش إعانة خليكم معايا خليكي معايا لأن يا
+
+157
+00:13:20,450 --> 00:13:27,470
+جماعة أنا أتحدث عن أنهإنسان بينصحني أو بطلب مني
+
+158
+00:13:27,470 --> 00:13:31,610
+نصيحة في موضوع يبيع بسعر اليوم ولا يأجلها كمان
+
+159
+00:13:31,610 --> 00:13:35,810
+أسبوع يمكن يصير غلق للأسعار وكذا قال لي كان يجب
+
+160
+00:13:35,810 --> 00:13:40,830
+أني أقوله لأن النصيحة لمن طلبها واجبة قضية إنه
+
+161
+00:13:40,830 --> 00:13:46,450
+إعانة على الحرام لأ هو ابتداء خليكي معاياابتداء يا
+
+162
+00:13:46,450 --> 00:13:51,050
+جماعة هذا اللي جاي يبيع بعرفش أصلا الأسعار و أنا
+
+163
+00:13:51,050 --> 00:13:56,530
+كتاجر دائما بدور على مصلحتى و لأن لو بدنا نتحدث
+
+164
+00:13:56,530 --> 00:13:59,970
+بالمنطقه اللي انت بتقوله معناته ما بجوز للتجار
+
+165
+00:13:59,970 --> 00:14:04,300
+يربحهكأنه بنقول هيك وهذه مشكلة فانا عادي جدا ..
+
+166
+00:14:04,300 --> 00:14:08,120
+انا عادي جدا لما أكون تاجر أبيع بالربح اللي بديه
+
+167
+00:14:08,120 --> 00:14:11,700
+لكن بدون غشه بدون خداعه بدون و بدون مافيش أي مشكلة
+
+168
+00:14:11,700 --> 00:14:15,880
+حتى لو كانت الأرباح طائلة لأن أصلا التجارة ربح و
+
+169
+00:14:15,880 --> 00:14:20,260
+خسارة فانا يوم بربح و يوم باجي بالأرض يعني فهي هيك
+
+170
+00:14:20,260 --> 00:14:23,560
+المسألة مافيش دائما مش دائما طالع فبصير إشي بيجبر
+
+171
+00:14:23,560 --> 00:14:28,630
+إشي تمام؟هذا القول الأول القول الثاني قالك لا يجب
+
+172
+00:14:28,630 --> 00:14:34,010
+لحظي قالك لا يجب مش لا يجوز لا يجب معناته بنفع
+
+173
+00:14:34,010 --> 00:14:37,930
+بنفع أو بنفع لا الأول قالك لأ لازم بمعنى لو ما
+
+174
+00:14:37,930 --> 00:14:43,130
+أرشدوش إيش آسم القول التاني قالك لا يجب فلا هو حر
+
+175
+00:14:43,130 --> 00:14:49,170
+بده ينصح أو ماينصحش هو حر فلا يجب ليش قالك عساس ما
+
+176
+00:14:49,170 --> 00:14:55,140
+نضايقش عن ناس عساس ما نضايقش عن ناس علم؟واضح؟ تمام
+
+177
+00:14:55,140 --> 00:15:02,080
+نيجي الأن لتلقي الركبان انركز شوية في موضوع تلقي
+
+178
+00:15:02,080 --> 00:15:07,220
+الركبان سهلة برضه
+
+179
+00:15:07,220 --> 00:15:11,760
+أمثلاتنا افتراضيةالان يا جماعة أبدا لما بنحكي
+
+180
+00:15:11,760 --> 00:15:15,680
+رقبان جريان على الغالب لأن بالغالب كانوا التجار
+
+181
+00:15:15,680 --> 00:15:20,060
+لما بينتقلوا من مكان لمكان بيجوا بضاعتهم محملينها
+
+182
+00:15:20,060 --> 00:15:25,020
+على دوابهم الله يكرمكم على كذا فاليوم بقولك سواء
+
+183
+00:15:25,020 --> 00:15:31,120
+على الدب على تكتك على شاحن على وسائل نقل مختلفة أو
+
+184
+00:15:31,120 --> 00:15:35,160
+حتى على راسه بدي أفطر الجدلة جاي بالبضاعة على راسه
+
+185
+00:15:35,160 --> 00:15:40,170
+جاي يمشي فكله بيدخل نفس الحكم تمام؟فالان موضوع
+
+186
+00:15:40,170 --> 00:15:43,810
+تلقي الركبان بدنا نفطرت يا جماعة احنا مثلا هنا في
+
+187
+00:15:43,810 --> 00:15:48,710
+غزة المعبر التجاري اللي من خلاله بتدخل السلع علينا
+
+188
+00:15:48,710 --> 00:15:55,630
+هو كرم أبو سالم صح ولا لا؟ حلو فاليوم
+
+189
+00:15:55,630 --> 00:15:59,330
+بدي أفطرت يا جماعة هذا المعبر كرم أبو سالم
+
+190
+00:16:02,030 --> 00:16:05,630
+بدنا نركز شوية ع ساس نقول بعض الأحكام لكن ده أرجع
+
+191
+00:16:05,630 --> 00:16:11,330
+أكد على نقطة أن كل هذه البيوغ صحيحة صحيحة لكن
+
+192
+00:16:11,330 --> 00:16:17,030
+مانهى عنها لوجود خلل خارج عن البيع خلّيكم معايا
+
+193
+00:16:17,030 --> 00:16:23,850
+الآن يا جماعة بدي أفترض بالأخبار قالوا المعبر فتح
+
+194
+00:16:23,850 --> 00:16:28,850
+وكذا اجوا تجار غزة النشامة ما شاء الله عنهم راحوا
+
+195
+00:16:28,850 --> 00:16:37,340
+إيش يرابطوا على ثغور المعبرتمام؟ حلو؟ فباكفين هنا؟
+
+196
+00:16:38,120 --> 00:16:42,740
+بينتظروا بمين؟ بالركبان بينتظروا هان خارج البلد هي
+
+197
+00:16:42,740 --> 00:16:46,460
+البلد هه هي البلد و هان خارج البلد فبينتظروا
+
+198
+00:16:46,460 --> 00:16:52,620
+الركبان حتى يطلقوا منهم السلع و إيش و ياخدوها منهم
+
+199
+00:16:52,620 --> 00:16:56,560
+فحتى نقول هذا منهي عنه بدنا نتكلم عن تلات شغلات
+
+200
+00:16:56,560 --> 00:16:59,960
+وقتها بيكون في إثم على المطلق وإذا اتخلفت هذه
+
+201
+00:16:59,960 --> 00:17:04,740
+الشغلات ماعدش في إثم، تمام؟ الآن الشغلة الأولى إنه
+
+202
+00:17:04,740 --> 00:17:09,000
+يكونوا هدول اللي اطلقوايكونوا الرقبان خارج البلد
+
+203
+00:17:09,000 --> 00:17:13,120
+هذه النقطة الأولى، الرقبان خارج البلد وبناء على
+
+204
+00:17:13,120 --> 00:17:16,060
+ذلك على طول وانت مغامضة إذا كانوا داخل البلد
+
+205
+00:17:16,060 --> 00:17:20,060
+ماسموش تلقي، وبغض النظر ضحكوا عليهم، ماضحكوش
+
+206
+00:17:20,060 --> 00:17:23,580
+عليهم، مافيش أي إسم ولا أي حاجة، هنحكي، إذا أول
+
+207
+00:17:23,580 --> 00:17:27,260
+نقطة يكونوا الرقبان خارج البلد، عشان هيك قلتلك
+
+208
+00:17:27,260 --> 00:17:32,360
+بيربطوا على الثجور، واقفين بستنوهم، حلوالنقطة
+
+209
+00:17:32,360 --> 00:17:38,220
+التانية ان يكونوا الرقبان قد غوبلوا بالثمن، يعني
+
+210
+00:17:38,220 --> 00:17:41,940
+انضحك عليهم جايبين معاهم كذا container من الإبداع
+
+211
+00:17:41,940 --> 00:17:46,260
+اللي بدهم يبيعوها و ثمانها انه بغزة بمية ألف دولار
+
+212
+00:17:47,740 --> 00:17:52,080
+فهدول المتلقين راحوا اشتروها قبل ما يدخلوا بـ 80
+
+213
+00:17:52,080 --> 00:17:56,140
+ألف أعطوهم الـ 80 ألف و أخدوا الإبداع و روحوا على
+
+214
+00:17:56,140 --> 00:18:01,500
+غزة هدول أهل غزة تمام؟ المتلقين بنقول عنهم في هذه
+
+215
+00:18:01,500 --> 00:18:08,420
+الحالة هم قاتلين لكن في شرط أن هدول جهلين السعر
+
+216
+00:18:09,680 --> 00:18:13,280
+جاهلين السعادة بمعنى مرة تانية ركز هي الأمور بدأت
+
+217
+00:18:13,280 --> 00:18:17,960
+تدخل عباعد لكنها سهلة أول شي بنقول أن التلقى بدي
+
+218
+00:18:17,960 --> 00:18:23,600
+يكون خارج البلد هي واحد الشغلة التانية أن الركبان
+
+219
+00:18:23,600 --> 00:18:31,850
+غبنوا بالسقر مع جاهلهم بهيغُبِلوا وكانوا جاهلين طب
+
+220
+00:18:31,850 --> 00:18:36,350
+لو كانوا عارفين انتوا الهمل يعني انتوا عارفين ان
+
+221
+00:18:36,350 --> 00:18:39,030
+الأبداع اننا هذه اللي انتوا جبتوها بتنبع اننا ب
+
+222
+00:18:39,030 --> 00:18:44,250
+100 ألف ومع ذلك رضيكوا تبيعوها ب 80 ألف في اي
+
+223
+00:18:44,250 --> 00:18:48,350
+مشكلة هذه شطارتي انا كغزاوي انتوا الهمل مثلا صح
+
+224
+00:18:48,350 --> 00:18:52,670
+ولا لأ وبناء على ذلك نرجع نقول ان مطلقي خارج البلد
+
+225
+00:18:52,670 --> 00:18:58,070
+بالاضافة لذلك لحق الرقبان الغُبُل مع جهلهم بيه
+
+226
+00:18:59,430 --> 00:19:03,470
+وبنان على ذلك نيجي نبطل هذا الكلام، الآن إذا
+
+227
+00:19:03,470 --> 00:19:09,450
+الركبان هدول اللي معاهم إبضاعة و هم خارج البلد،
+
+228
+00:19:09,450 --> 00:19:13,430
+المطلقين اشتروا منهم الإبضاعة ب 80 ألف يعني غبنوهم
+
+229
+00:19:13,430 --> 00:19:20,730
+و هم جاهلين بهذا الثمنوبعد ذلك عرفوا بعد عرفوا أنه
+
+230
+00:19:20,730 --> 00:19:24,850
+نضحك عليهم هل يثبت لهم الخيار نقول نعم يثبت لهم
+
+231
+00:19:24,850 --> 00:19:29,590
+الخيار و الخيار يجب أن يكون فوريا شو يعني بمجرد ما
+
+232
+00:19:29,590 --> 00:19:32,530
+عرفوا يرجعوا بسرعة بسرعة لأ هاتوا خلاص أنا بطلت
+
+233
+00:19:32,530 --> 00:19:36,450
+أنا بدي أبيع لحالي بينفع أه بينفع لهم الخيار بينما
+
+234
+00:19:36,450 --> 00:19:42,610
+لو عرفوا بعد البيت طبعا عرفوا و سكتوا فسقط الخيار
+
+235
+00:19:42,610 --> 00:19:47,960
+عرفوا و سكتوا سقط الخيارو أيضا يسقط الخيار يعني
+
+236
+00:19:47,960 --> 00:19:52,700
+مالهمش يتراجعوا فيما لو كانوا من البداية عارفين
+
+237
+00:19:52,700 --> 00:19:58,020
+بالثمن و رضيوا بيه الغبط فإذا بعد هيك بنفعش ييجي
+
+238
+00:19:58,020 --> 00:20:02,280
+يقولوا بطلنا لأن انتوا ضحكتوا علينا الأمر التالت
+
+239
+00:20:02,280 --> 00:20:06,160
+إذا هم دخلوا .. بدنا نفترض هي السوق يا جماعة هي
+
+240
+00:20:06,160 --> 00:20:11,020
+السوق و هم دخلوا البلد الرقبان دخلوا و هم هنصروا
+
+241
+00:20:11,020 --> 00:20:17,210
+في التلقيفي داخل البلد حتى لو خارج السوق المهم
+
+242
+00:20:17,210 --> 00:20:22,330
+داخل البلد وانا كمتلقي روحت اشتريت منهم الإبداع ب
+
+243
+00:20:22,330 --> 00:20:27,090
+80 ألف و هي بتسوأ 100 ألف مع ذلك مافيش أسم علي ولا
+
+244
+00:20:27,090 --> 00:20:32,410
+أدخل في انهي ليش لأن انتوا المجسرين كونكوا دخلتوا
+
+245
+00:20:32,410 --> 00:20:36,310
+في البلد أسأله ما تقولوا ما هم مش عارفين و عارفين
+
+246
+00:20:36,310 --> 00:20:40,530
+لأ انتوا دخلتوا في البلد هناك قلنا معاكوا حد
+
+247
+00:20:40,530 --> 00:20:45,740
+لأنكوا برا البلدفقلنا معاكوا حاجة فافسخوا كونكوا
+
+248
+00:20:45,740 --> 00:20:51,520
+دخلتم البلد حتى لو حد اللي ضحك عليكم فمالكماش
+
+249
+00:20:51,520 --> 00:20:55,660
+تتراجعوا و تفسخوا لأن التقسير منكم كان بإمكانكم
+
+250
+00:20:55,660 --> 00:21:00,620
+تسألوا عن السعر في البلد بإمكانكم أي حد تسألوا يا
+
+251
+00:21:00,620 --> 00:21:04,180
+عم هذه الشغل جديش بتنبع عندكم في السوق وخلصنا
+
+252
+00:21:04,180 --> 00:21:07,620
+بعدين انتوا حرين ترضوا ولا ما ترضوش لكن كونكوا
+
+253
+00:21:07,620 --> 00:21:13,060
+مرضيتوا حتى لو بأقل من ثمن المثالكونكم داخل البلد
+
+254
+00:21:13,060 --> 00:21:19,000
+مافيه لكم خيار علم واضح تمام إذا نرجع نقول بأنه
+
+255
+00:21:19,000 --> 00:21:25,180
+تلقى الركبانيعدوا من البيوع المنهي عنه والإثم على
+
+256
+00:21:25,180 --> 00:21:30,380
+المتلقي لماذا مافي خلال لا في الأركان ولا في
+
+257
+00:21:30,380 --> 00:21:34,620
+الشروط بتكملي بعدين لا في الأركان ولا في الشروط
+
+258
+00:21:34,620 --> 00:21:40,680
+لكن إيش صار في إضرار بالطرف الآخر لذلك يقول نبينا
+
+259
+00:21:40,680 --> 00:21:46,400
+صلى الله عليه وسلم لا تلقوا الركبان وفي حديث آخر
+
+260
+00:21:46,400 --> 00:21:53,850
+يقول صلى الله عليه وسلم لا تلقوا السلعيهبط بها إلى
+
+261
+00:21:53,850 --> 00:21:59,390
+السوق فمن تلقاها فصاحب السلعة بالخيار وقولنا متى
+
+262
+00:21:59,390 --> 00:22:05,490
+يثبت له الخيار علم؟ في أي سؤال؟ طيب ننتقل لـ
+
+263
+00:22:22,710 --> 00:22:27,010
+إذا قلنا متى يسقط الخيار؟ يسقط الخيار إذا طلبوا هم
+
+264
+00:22:27,010 --> 00:22:30,530
+من المتلقي أن يشتري منهم حتى لو كانوا يجهلون
+
+265
+00:22:30,530 --> 00:22:34,270
+السعر، إذا هم اللي طلبوا يشتري مني، الأمر التاني
+
+266
+00:22:34,270 --> 00:22:38,010
+إذا لم يغبنوا ما نضحكش عليهم، يعني حتى التلقي صار
+
+267
+00:22:38,010 --> 00:22:42,710
+هان و أنا اشترت منهم 100 ألففي مشكلة؟ لأ مافي
+
+268
+00:22:42,710 --> 00:22:47,210
+مشكلة و مالهمش إيش يفسخوا العقد الأمر اللي بعده
+
+269
+00:22:47,210 --> 00:22:52,510
+إذا كان التلقي داخل البلد حتى لو كان خارج السوق في
+
+270
+00:22:52,510 --> 00:22:57,290
+هذه الحالات لا يجوز للركباني أن يفسخوا العقد اللذي
+
+271
+00:22:57,290 --> 00:23:02,030
+أبرموه مع المتلقين لأنهم في الصورة الأولى التي
+
+272
+00:23:02,030 --> 00:23:06,590
+ذكرتها غير متضررين باعتبار أن هما عارفينالأو هم
+
+273
+00:23:06,590 --> 00:23:09,750
+اللي طلبوا يشتري منه، يشتروا مني حتى لو كانوا
+
+274
+00:23:09,750 --> 00:23:13,170
+بيعرفوش الساعة، يعني هم مابيعرفوا بجدش بتنبع في
+
+275
+00:23:13,170 --> 00:23:17,110
+غزة، لجوا تشجار غزة موجودين، اشجلوا لهم شو رأيكوا
+
+276
+00:23:17,110 --> 00:23:20,290
+تشتروا مننا و بدنا إيش ندخل عندكوا غزة، بنخاف في
+
+277
+00:23:20,290 --> 00:23:25,970
+عندكوا قصر، في يهود، مثلا ففي هذه الحالةفروحت أنا
+
+278
+00:23:25,970 --> 00:23:30,670
+استغلت الفرصة كتاجر غزاوي ودفعت لهم حتى لو بالأقل،
+
+279
+00:23:30,670 --> 00:23:33,690
+في مشكلة؟ لأ مالكمش إشي عندي لأنه أنتم اللي طلبتم
+
+280
+00:23:33,690 --> 00:23:37,670
+مني مش أنا اللي بدرت والأمر التالت فيما لو دخلوا
+
+281
+00:23:37,670 --> 00:23:43,250
+البلد لكن قبل ما يدخلوا السوق إطلقتهم فأيضا مافي
+
+282
+00:23:43,250 --> 00:23:50,120
+مشكلة ومالهمش خيار في هذا الأمر علم؟ طيبنيجي الأن
+
+283
+00:23:50,120 --> 00:23:55,940
+لصوم على صوم الغير الصوم على صوم الغير يالا إسلام
+
+284
+00:23:55,940 --> 00:24:01,660
+برك
+
+285
+00:24:01,660 --> 00:24:04,980
+الله فيك الأن يا جماعة لما بدنا نتحدث عن الصوم على
+
+286
+00:24:04,980 --> 00:24:08,680
+صوم الغير البيع على بيع الغير الشراء على شراء
+
+287
+00:24:08,680 --> 00:24:14,040
+الغير الفكرة واحدة لكن مع اختلاف بسيط في تكييف ان
+
+288
+00:24:14,040 --> 00:24:17,880
+صح التعبير كل صورة من هذه الصورةالان في موضوع
+
+289
+00:24:17,880 --> 00:24:22,160
+السوم، لحظة معايا موضوع السوم بالعادة هو مفاوضة
+
+290
+00:24:22,160 --> 00:24:26,100
+صاحب السلع على ثمنها، صح ولا لأ؟ فاللي بيصير أنا
+
+291
+00:24:26,100 --> 00:24:29,880
+بروح على السوق، بعرض سلعتي في السوق، بيجي فلان
+
+292
+00:24:29,880 --> 00:24:35,740
+يقول 80%، بقوله لأفلان اتبعيني ب 120 لا اتبعيني
+
+293
+00:24:35,740 --> 00:24:40,140
+بكذا لأ لأ لأ ايش يعني فلان مثلا ها لحظي معايا انا
+
+294
+00:24:40,140 --> 00:24:42,940
+كنت اقول لأ يعني ماكان في توافق بيني وبين اي حد من
+
+295
+00:24:42,940 --> 00:24:48,980
+اللي دفعلي ثمن فإيجى فلان جالي اتبعيني ب 150أنا
+
+296
+00:24:48,980 --> 00:24:53,400
+بدي أشتريها بمية و خمسين قلتله يلا منيح مش مشكلة
+
+297
+00:24:53,400 --> 00:25:00,300
+لسه ما بقت مافي بيع لسه ما بقت صار في توافق مبدئي
+
+298
+00:25:00,300 --> 00:25:06,140
+على الثمن بيني وبين المشتري طبعا بنسمي مشتري مجازا
+
+299
+00:25:06,140 --> 00:25:10,200
+باعتبار هيشتري لأنه خلاص اتوافقنا لأنه لسه فيش عقد
+
+300
+00:25:10,200 --> 00:25:15,690
+كونه فيش عقد مش مشتريفالان نحظى معايا صار فى توافق
+
+301
+00:25:15,690 --> 00:25:20,530
+على الثمن لسه ما أبربناش .. ما أبربناش الأقدم اللى
+
+302
+00:25:20,530 --> 00:25:25,470
+هى إسلعة عم بدنا نسميها بين جثانى بتتحمل سوسة إجت
+
+303
+00:25:25,470 --> 00:25:30,610
+بدها تخربها البيع .. إجت بدها تخربها البيعفبعد أن
+
+304
+00:25:30,610 --> 00:25:34,930
+تم الاتفاق بين البائع والمشتري على هذا الثمن
+
+305
+00:25:34,930 --> 00:25:40,250
+فإسلام إجت تقول أنا بشتريها ب 200، اتبيعني إياها ب
+
+306
+00:25:40,250 --> 00:25:45,370
+200؟ طبيعي جدا لما أسمع العرض من إسلام، هبطل مع
+
+307
+00:25:45,370 --> 00:25:49,910
+اللي كنت أنا متفج معاه، صح ولا لأ؟ هبطل، أحلغ
+
+308
+00:25:49,910 --> 00:25:53,530
+اتفاجي معاه و أبيل إسلام لأنه دائما مصلحة البايع
+
+309
+00:25:53,530 --> 00:25:58,600
+أن يبيع بأعلى الأثمان، فأنا مافيش اسم علياومين
+
+310
+00:25:58,600 --> 00:26:03,700
+اللي اتضرر؟ المش ذاري اتضرر على الأقل نفسيا صح ولا
+
+311
+00:26:03,700 --> 00:26:09,700
+لا؟ فبالتالي القاثم هو السائم الآخر لكن حتى نقول
+
+312
+00:26:09,700 --> 00:26:14,400
+هي قاثمة يجب شغل تاني يتوفر و اللي قلناهم أن يكون
+
+313
+00:26:14,400 --> 00:26:18,360
+فيه توافق على السعر لأنه .. بدي أجيب مثال تاني
+
+314
+00:26:18,360 --> 00:26:23,040
+فرضا أنا وفلان قال لي بدي أشتري 150 و لسه ماقلتلهش
+
+315
+00:26:23,040 --> 00:26:25,960
+okay إجت اسلان قالت أنا بدي أشتري 200، في
+
+316
+00:26:25,960 --> 00:26:31,630
+مشكلة؟فيش مشكلةلكن امتى في مشكلة لما انا والتانى
+
+317
+00:26:31,630 --> 00:26:34,670
+اللى ايجى يشتري منى توافقنا على السعر okay مافي
+
+318
+00:26:34,670 --> 00:26:39,410
+بيع لكن إلى حد ما خلاص يعني رايحين للبيع احنا
+
+319
+00:26:39,410 --> 00:26:44,370
+بعدين ايجى هذا السائم يسوم على سوم أخيه في هذه
+
+320
+00:26:44,370 --> 00:26:48,170
+الحالة نقول بأن هذا السائم اللى بنسميه بين بعض هنا
+
+321
+00:26:48,170 --> 00:26:54,880
+بس سوسة هذا يعد أثمان لأنه أراد التضيقعشان كده
+
+322
+00:26:54,880 --> 00:26:59,420
+نبينا صلى الله عليه وسلم يقول لا يسوموا الرجل على
+
+323
+00:26:59,420 --> 00:27:04,100
+سوم أخيه، ولحظة عبّر بأخيه، مش شقيقه، أخيه،
+
+324
+00:27:04,100 --> 00:27:10,040
+باعتبار المسلمين أخوة، وبالتالي الأخوة دائما مدعاة
+
+325
+00:27:10,040 --> 00:27:14,180
+لإن إحنا نجفجن بعيد، مش نطبش بعيد، تمام؟ فإنت لما
+
+326
+00:27:14,180 --> 00:27:18,880
+بتروح تشتري، لأ البياع مش أخوك في اللهمش أخوك في
+
+327
+00:27:18,880 --> 00:27:23,360
+الله مع أختك في الله okay هو مش أخوك في الله حلو
+
+328
+00:27:23,360 --> 00:27:28,060
+تمام فالأخوة بدنا نتفه للجنسين مع بعض عساس ما
+
+329
+00:27:28,060 --> 00:27:32,040
+تقولش لأ دي أخوة في الله صديقي في الله لأ يا ماما
+
+330
+00:27:32,040 --> 00:27:36,240
+مابظبطش طيب
+
+331
+00:27:36,240 --> 00:27:40,340
+اه اليوم في موضع انه أخي في الله زي أخويا لأ يا
+
+332
+00:27:40,340 --> 00:27:46,440
+ماما فش الشارع فش فيه زي أخويا فش حدا زي أخوك أخوك
+
+333
+00:27:46,440 --> 00:27:53,860
+هو أخوكأه بتاكد الاثم على السوسة على السوسة طيب
+
+334
+00:27:53,860 --> 00:27:58,960
+صلوا على رسول الله إذا لحظي معايا إن هذا البيع أو
+
+335
+00:27:58,960 --> 00:28:02,900
+أفوان السوم على سوم الغير التحريم فيه لازم يكون
+
+336
+00:28:02,900 --> 00:28:07,460
+إذا اتحقق الشرطين إنه لسه لم يبرم العقد بعد والأمر
+
+337
+00:28:07,460 --> 00:28:12,040
+التاني جميل إنه تم التوافق على الثمن وبالتالي لو
+
+338
+00:28:12,040 --> 00:28:15,770
+ما تم التوافق وحدنا إيجي يسوم مافي مشكلةلأنه طبيعة
+
+339
+00:28:15,770 --> 00:28:19,550
+السوم أن حد و حد و حد بيجي يسوم، صح ولا لا؟ جميل
+
+340
+00:28:19,550 --> 00:28:25,410
+نيجي الأن لبيع على بيع الغير، الفكرة واحدة، بس صار
+
+341
+00:28:25,410 --> 00:28:30,130
+فيه بيع، صار فيه بيع، يعني نيجي الأن نخلي اليوم
+
+342
+00:28:30,130 --> 00:28:37,070
+ضيف الشرف السوسة إسلام، هلجيت يا جماعة أنا و سجا؟
+
+343
+00:28:37,350 --> 00:28:40,270
+روحت باقتها .. ركزوا معايا .. باقتها جوالي بألف
+
+344
+00:28:40,270 --> 00:28:46,510
+شكل .. باقتها جوالي بألف شكل و تم البيع بيناتنا ..
+
+345
+00:28:46,510 --> 00:28:50,990
+في بيع .. في عقد .. لكن لساتنا في مجلس العقد ..
+
+346
+00:28:50,990 --> 00:28:54,650
+لساتنا في مجلس العقد و لما بقول لساتنا في مجلس
+
+347
+00:28:54,650 --> 00:28:59,890
+العقد يعني البيع غير لازم .. يعني عادي جدا اتراجع
+
+348
+00:28:59,890 --> 00:29:06,400
+.. جميلو احنا في مجلس العقد و اتبايعنا اجت حضرة
+
+349
+00:29:06,400 --> 00:29:11,620
+جنابي السوسة بدها الدور بمين؟ بالبائع لأنه ببايع
+
+350
+00:29:11,620 --> 00:29:18,260
+على بايع الغير يعني الإضرار بمين؟ تمام طبعا
+
+351
+00:29:18,260 --> 00:29:22,220
+راحت إيش تعمل؟ بتقول لسجة و احنا في مجلس أنا
+
+352
+00:29:22,220 --> 00:29:25,500
+ماطلعتش لأن انا لو طلعت مافيش مجلس صح ولا لأ فانا
+
+353
+00:29:25,500 --> 00:29:29,610
+موجودة فراحت لسجة إيش تقول لسجة؟بتقولها اقولك انت
+
+354
+00:29:29,610 --> 00:29:33,030
+هابلة بتشتري هذا الجوال بمية أب ألف شاكل انا
+
+355
+00:29:33,030 --> 00:29:38,090
+بجيبلك أحسن منه انا ببيقك أحسن منه بألف او ببيقك
+
+356
+00:29:38,090 --> 00:29:43,410
+زيه بتمانمية هه ببيقك أحسن منه بألف او زيه
+
+357
+00:29:43,410 --> 00:29:48,610
+بتمانمية سجة سمعتها الكلام بتأكيد مصلحتها الأفضل
+
+358
+00:29:48,610 --> 00:29:52,470
+صح ولا لا فإجت تقوللي مابديش أعطتلي جوالي و أخدت
+
+359
+00:29:52,470 --> 00:29:57,290
+فلوسها و راحت تشتري من اسلاممين اللي اتبرر؟ انا ..
+
+360
+00:29:57,290 --> 00:30:04,390
+انا اتبررت فبالتالي مين الاعثم؟السوسة اسم الصلاحى
+
+361
+00:30:04,390 --> 00:30:08,990
+الفقير نشتبته في الامتحان سوسة طيب ألف؟ لأ هو مش
+
+362
+00:30:08,990 --> 00:30:13,930
+سوى هنا الباقى التانى تمام حلو اذا لحظى معايا نفس
+
+363
+00:30:13,930 --> 00:30:18,230
+الشىء نبينا صلى الله عليه وسلم نهى أن يبيع الرجل
+
+364
+00:30:18,230 --> 00:30:23,090
+على بيع أخيه اذا ده يبيع أحدكم على بيع أخيه ونفس
+
+365
+00:30:23,090 --> 00:30:27,590
+العلة اللى ذكرناها لكن بنقول هنا انه حتى يحرم
+
+366
+00:30:27,590 --> 00:30:33,180
+البيع ياجب أن يكون البيع غير لازميجب أن يكون البيع
+
+367
+00:30:33,180 --> 00:30:35,940
+غير لازم، يعني في مجلس العقد، وبالتالي لو لازم
+
+368
+00:30:35,940 --> 00:30:40,240
+البيع صار لازم، خلاص، مافيش بيع على بيع الغير
+
+369
+00:30:40,240 --> 00:30:44,120
+أصلا، لأنه متى ما طلعنا من مجلس العقد مافيش تراجع
+
+370
+00:30:44,120 --> 00:30:50,010
+أصلا إلا بالتراضي، علم؟ تمام؟ حلوالشراع على شراع
+
+371
+00:30:50,010 --> 00:30:54,690
+الغير فكرة واحدة بس اتضرر لاتطرف التاني شراع على
+
+372
+00:30:54,690 --> 00:30:58,930
+شراع الغير المتضرر هو المشترك انا الان باعت ساجة
+
+373
+00:30:58,930 --> 00:31:04,530
+باعت ساجة جوالي بألف شكل و تم البيع بيننا لكننا
+
+374
+00:31:04,530 --> 00:31:09,450
+لازلنا في مجلس العقيد و احنا في مجلس العقيد شرفت
+
+375
+00:31:10,100 --> 00:31:17,240
+حضرة السوسة فالان اسلام اجت اجتني انا بتقولي كيف
+
+376
+00:31:17,240 --> 00:31:20,380
+بيحتي جوالك بالف شاكل انا بشتريه منك بال الف و
+
+377
+00:31:20,380 --> 00:31:25,400
+تلاتمية انا بشتريه بال الف و تلاتمية فلحظي معايا
+
+378
+00:31:25,400 --> 00:31:30,640
+انا كبيع بالتأكيد مصلحتي اني ابيع بالثمن الأعلى
+
+379
+00:31:30,640 --> 00:31:33,700
+فممكن بكل بساطة اقول لسجة خلاص هاي فلوسك و هاتي
+
+380
+00:31:33,700 --> 00:31:39,110
+الجوال و ايش ابيعه لا اسلام فمن اللي اتضررت سجةصح
+
+381
+00:31:39,110 --> 00:31:42,390
+ولا لا؟ وبناء على ذلك بنقول نبينا صلى الله عليه
+
+382
+00:31:42,390 --> 00:31:47,390
+وسلم نهى عن .. نهى الشراء على شراء .. او نهى عن
+
+383
+00:31:47,390 --> 00:31:51,970
+الشراء على شراء الغير، العلة في ذلك ان الحق اضرر
+
+384
+00:31:51,970 --> 00:31:57,540
+بالطرف الآخرلكن بنرجع نقول بإنه حتى نقول بالحرمة
+
+385
+00:31:57,540 --> 00:32:03,200
+لابد من أن يكون الشراء في مجلس العقد بمعنى إنه لسه
+
+386
+00:32:03,200 --> 00:32:07,840
+العقد غير لازم لأنه لو أصبح لازما لم يعد هناك أي
+
+387
+00:32:07,840 --> 00:32:13,580
+إشكالية باعتباري أن الفسخة متأذت تمام؟ حلوالإمام
+
+388
+00:32:13,580 --> 00:32:17,440
+الشافعى راح جابلنا صورة ألحقها بموضوع البيع و
+
+389
+00:32:17,440 --> 00:32:20,640
+الشراء على شراء الغير والإمام المواردى أيضًا وهو
+
+390
+00:32:20,640 --> 00:32:26,040
+شافعى جاء أيضًا بصورة تلحقه بموضوع البيع على بيع
+
+391
+00:32:26,040 --> 00:32:29,880
+الغير نركز سريعًا أعيد الصورتين اللي ذكرناهم بلان
+
+392
+00:32:29,880 --> 00:32:37,260
+عليهم نلحق الصور الجديدة عينا يا جماعةموضوع الصورة
+
+393
+00:32:37,260 --> 00:32:43,780
+الأولى إنه الإضرار كان بالبائع فإجا الشخص إيش عمل؟
+
+394
+00:32:43,780 --> 00:32:52,040
+راح أراد أن يبيع سلعةأو يبيع السلعة بنفس الثمن لكن
+
+395
+00:32:52,040 --> 00:32:55,600
+أفضل من السلعة اللى اشتراها المشتري للمشتري و هم
+
+396
+00:32:55,600 --> 00:33:00,220
+فى مجلس العقد او انه يروح للمشتري او يروح للبائع
+
+397
+00:33:00,220 --> 00:33:04,260
+يشتري منه السلعة بأعلى من ثمنها فبيصير إضرار لكن
+
+398
+00:33:04,260 --> 00:33:08,400
+الشافعي جال بدنا نفترض جدلان تم الباع نفترض أنا و
+
+399
+00:33:08,400 --> 00:33:13,220
+سجا بيعنا و تمام تمام و احنا فى مجلس العقدفإجت
+
+400
+00:33:13,220 --> 00:33:17,640
+إسلام عاملة حالها بريقة، إيش تعمل؟ ما راحتش تقول
+
+401
+00:33:17,640 --> 00:33:22,580
+أبيعك و أشتري و بصرشوك، جايبة معها جوال، تيبة، كلب
+
+402
+00:33:22,580 --> 00:33:27,870
+من اللي أنا اشتريتهجايبة جوال typical من اللي أنا
+
+403
+00:33:27,870 --> 00:33:30,350
+لساتني في مجلس العقد و عمالي شاريها هذا الجوال
+
+404
+00:33:30,350 --> 00:33:37,550
+فإيجاتني إسلامة تقولي أنه معها جوال بتقولي والله
+
+405
+00:33:37,550 --> 00:33:40,710
+إيش رأيك بهذا الجوال؟ والله شايفة أجانسه حلو والله
+
+406
+00:33:40,710 --> 00:33:43,250
+بدي أبيعه، شو رأيك تبيعيه؟ شوف اتفرج يعني، إذا
+
+407
+00:33:43,250 --> 00:33:48,680
+عجبك بدي أبيعك إياه، كذا كذا، هاألا يعد هذا الأمر
+
+408
+00:33:48,680 --> 00:33:52,500
+مادعا لإني أنا أفسخ العقد إذا هذا عجبني أكتر من
+
+409
+00:33:52,500 --> 00:33:56,860
+هداك؟ صح ولا لأ؟ فإذا نبتلحق بنفس الاش الصورة
+
+410
+00:33:56,860 --> 00:34:01,460
+بمعنى أنها تعد قافمة لأن هذا البيع الجديد هيؤثر
+
+411
+00:34:01,460 --> 00:34:05,940
+على البيع القديم وبالتالي تضرر البائع لإني ممكن
+
+412
+00:34:05,940 --> 00:34:09,570
+أرجعله السلعة، صح؟تمام في صورة تانية ذكرها
+
+413
+00:34:09,570 --> 00:34:14,370
+المواردة بيقول فيها ان لو صار بيع بنى و بنسجى و تم
+
+414
+00:34:14,370 --> 00:34:18,870
+البيع مية بالمية لكن لساتنا في مجلس العقد اجت
+
+415
+00:34:18,870 --> 00:34:23,750
+اسلام الي لحظة بدي افترض انا المشتري هلجأت اجت
+
+416
+00:34:23,750 --> 00:34:27,920
+اسلام الي انا كمشتريبعد ما تم البيع و احنا لسه في
+
+417
+00:34:27,920 --> 00:34:31,860
+مجلس العقد و على مرأة و مسمع من سجة كبائع اجت
+
+418
+00:34:31,860 --> 00:34:36,620
+تقوللي شو رأيك الجوال هذا اللي انا اشتريته من سجة
+
+419
+00:34:36,620 --> 00:34:40,080
+شو رأيك الجوال هذا تبيقيني ياب 1500 شاكل مع اني
+
+420
+00:34:40,080 --> 00:34:43,580
+انا توشر ياب ألف هه توشر ياب ألف فاجت تقوللي شو
+
+421
+00:34:43,580 --> 00:34:46,280
+رأيك تبيقيني ياب 1500 شاكل؟
+
+422
+00:34:49,710 --> 00:34:56,250
+مش هدا الكلام ممكن يخليها انه تاكل حالها من الندم
+
+423
+00:34:56,250 --> 00:35:00,530
+و تقعد تقول ياريتني انا اللي بعته 1500 انا الاولى
+
+424
+00:35:00,530 --> 00:35:04,390
+بالربح حدا من الطرف التانى وبالتالي هتيجي تقوللي
+
+425
+00:35:04,390 --> 00:35:06,950
+اسمعى هاتي الجوال خلاص مديش ابيعك و تروحي تبيعه
+
+426
+00:35:06,950 --> 00:35:10,950
+لسجة عساس طمعا في الحصول على الربح صح ولا لا؟ فهي
+
+427
+00:35:10,950 --> 00:35:15,210
+حتى لو فعلت ذلك مش ااتم الاتم هو الطرف التانى علم؟
+
+428
+00:35:17,830 --> 00:35:20,890
+ما هو شوفي بدي أقولك شغلة الفكرة هالجيت مش قصد أو
+
+429
+00:35:20,890 --> 00:35:25,850
+مش قصد طالما أنها عارفة أنه صار في بيع حتى لو مش
+
+430
+00:35:25,850 --> 00:35:30,450
+نيتها تخرب طالما عارفة في بيع معناته في إضرار جصدت
+
+431
+00:35:30,450 --> 00:35:34,510
+الضر و لا ما جصدتش لأنه هي صارت عارفة أني عمال
+
+432
+00:35:34,510 --> 00:35:39,810
+اشتريت وصلت الفكرة تمام هذا بالنسبة ليه سوم على
+
+433
+00:35:39,810 --> 00:35:44,050
+سوم الغير بيع على بيع الغير شرع على شرع شراع على
+
+434
+00:35:44,050 --> 00:35:45,910
+شراع الغير تمام طيب
+
+435
+00:35:49,680 --> 00:35:54,340
+طبعا المحاضرة القادمة بإذن الله بنتحدث عن موضوع
+
+436
+00:35:54,340 --> 00:35:59,440
+النجاش بيع النجاش و أيضا غيرها من البيوع المنهي
+
+437
+00:35:59,440 --> 00:36:02,940
+عنها إلى هنا نكون قد انتهينا من موضوع محاضرتنا
+
+438
+00:36:02,940 --> 00:36:06,860
+أقول قولي هذا واستغفر الله لي ولكم وصلى اللهم و
+
+439
+00:36:06,860 --> 00:36:10,380
+السلام و البارك على سيدنا محمد والسلام عليكم ورحمة
+
+440
+00:36:10,380 --> 00:36:11,560
+الله وبركاته
+
diff --git a/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/G1fnq2uDc_s_raw.json b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/G1fnq2uDc_s_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..dd2c343343557e46f929024b3dd3f5ba2fab870d
--- /dev/null
+++ b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/G1fnq2uDc_s_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2341, "start": 5.55, "end": 23.41, "text": "أعوذ بالله السماء لعليمنا الشيطان الرجيم بسم الله الرحمن الرحيم الحمد لله رب العالمين والصلاة والسلام على أشرف الأنبياء أيها المرسلين سيدنا محمد بن عبد الله الصادق الأمن ثم أما بعد أحييكم جميعا بتحية الإسلام في السلام عليكم ورحمة الله تعالى وبركاته", "tokens": [10721, 3615, 2407, 8848, 20666, 43761, 21136, 2304, 16606, 5296, 3615, 20292, 2304, 8315, 25124, 1829, 9566, 7649, 34892, 7435, 32640, 4724, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 21542, 2304, 3215, 24976, 3224, 12602, 3555, 18863, 45340, 9957, 16070, 9381, 15040, 3660, 16070, 3794, 37440, 15844, 5551, 8592, 28480, 16247, 1863, 21292, 16606, 36632, 11296, 9673, 2288, 3794, 1211, 9957, 8608, 25708, 8315, 3714, 35571, 3215, 44945, 6225, 44510, 21984, 31767, 18513, 4587, 16247, 27842, 38637, 2304, 5551, 15042, 39182, 5551, 5016, 1829, 1829, 24793, 10874, 2304, 40228, 995, 39894, 5016, 10632, 33688, 3794, 37440, 8978, 21136, 37440, 25894, 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{"start": 14.59, "end": 15.03, "word": " محمد", "probability": 0.9890950520833334}, {"start": 15.03, "end": 15.15, "word": " بن", "probability": 0.794921875}, {"start": 15.15, "end": 15.43, "word": " عبد", "probability": 0.9755859375}, {"start": 15.43, "end": 15.65, "word": " الله", "probability": 0.6005859375}, {"start": 15.65, "end": 16.09, "word": " الصادق", "probability": 0.9817708333333334}, {"start": 16.09, "end": 16.37, "word": " الأمن", "probability": 0.775390625}, {"start": 16.37, "end": 16.69, "word": " ثم", "probability": 0.98046875}, {"start": 16.69, "end": 16.95, "word": " أما", "probability": 0.86962890625}, {"start": 16.95, "end": 17.37, "word": " بعد", "probability": 0.9443359375}, {"start": 17.37, "end": 18.33, "word": " أحييكم", "probability": 0.92265625}, {"start": 18.33, "end": 18.87, "word": " جميعا", "probability": 0.9693603515625}, {"start": 18.87, "end": 19.31, "word": " بتحية", "probability": 0.95556640625}, {"start": 19.31, "end": 19.77, "word": " الإسلام", "probability": 0.9651692708333334}, {"start": 19.77, "end": 19.91, "word": " في", "probability": 0.423095703125}, {"start": 19.91, "end": 20.23, "word": " السلام", "probability": 0.912841796875}, {"start": 20.23, "end": 20.89, "word": " عليكم", "probability": 0.930419921875}, {"start": 20.89, "end": 21.33, "word": " ورحمة", "probability": 0.9832763671875}, {"start": 21.33, "end": 21.51, "word": " الله", "probability": 0.98095703125}, {"start": 21.51, "end": 22.51, "word": " تعالى", "probability": 0.9357096354166666}, {"start": 22.51, "end": 23.41, "word": " وبركاته", "probability": 0.93955078125}], "temperature": 1.0}, {"id": 2, "seek": 5378, "start": 24.4, "end": 53.78, "text": "كيف حالكم؟ طيبات ان شاء الله؟ تحضيرنا جيد ان شاء الله؟ طيب عظيم إذا كنا قد تحدثنا المحاضرة السابقة حول أركان عقد الرهن وقررنا إن عقد الرهن كوله تبعي لابد فيه من أربع أركان تتمثل في الصيغة والعاقدين والمعقود عليه أي المرهون والمرهون به اللي هو الدين فسبق وان تحدثنا عن أول رقم من هذه الأركان اللي هو الصيغة", 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"avg_logprob": -0.1161151972471499, "compression_ratio": 2.1904761904761907, "no_speech_prob": 3.159046173095703e-06, "words": [{"start": 24.4, "end": 24.74, "word": "كيف", "probability": 0.956298828125}, {"start": 24.74, "end": 25.28, "word": " حالكم؟", "probability": 0.7069091796875}, {"start": 25.28, "end": 25.6, "word": " طيبات", "probability": 0.9384765625}, {"start": 25.6, "end": 25.72, "word": " ان", "probability": 0.59423828125}, {"start": 25.72, "end": 25.88, "word": " شاء", "probability": 0.981689453125}, {"start": 25.88, "end": 26.42, "word": " الله؟", "probability": 0.8427734375}, {"start": 26.42, "end": 27.58, "word": " تحضيرنا", "probability": 0.895703125}, {"start": 27.58, "end": 28.0, "word": " جيد", "probability": 0.975341796875}, {"start": 28.0, "end": 28.2, "word": " ان", "probability": 0.8369140625}, {"start": 28.2, "end": 28.32, "word": " شاء", "probability": 0.993896484375}, {"start": 28.32, "end": 28.78, "word": " الله؟", "probability": 0.911376953125}, {"start": 28.78, "end": 29.52, "word": " طيب", "probability": 0.9191080729166666}, {"start": 29.52, "end": 30.22, "word": " عظيم", "probability": 0.958984375}, {"start": 30.22, "end": 30.84, "word": " إذا", "probability": 0.5194091796875}, {"start": 30.84, "end": 31.14, "word": " كنا", "probability": 0.9658203125}, {"start": 31.14, "end": 31.36, "word": " قد", "probability": 0.983154296875}, {"start": 31.36, "end": 32.06, "word": " تحدثنا", "probability": 0.9749755859375}, {"start": 32.06, "end": 32.8, "word": " المحاضرة", "probability": 0.978759765625}, {"start": 32.8, "end": 33.54, "word": " السابقة", "probability": 0.9899088541666666}, {"start": 33.54, "end": 34.12, "word": " حول", "probability": 0.97705078125}, {"start": 34.12, "end": 34.9, "word": " أركان", "probability": 0.91259765625}, {"start": 34.9, "end": 35.4, "word": " عقد", "probability": 0.99267578125}, {"start": 35.4, "end": 36.02, "word": " الرهن", "probability": 0.9337565104166666}, {"start": 36.02, "end": 38.1, "word": " 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{"start": 44.16, "end": 44.54, "word": " الصيغة", "probability": 0.9705810546875}, {"start": 44.54, "end": 45.36, "word": " والعاقدين", "probability": 0.87470703125}, {"start": 45.36, "end": 45.98, "word": " والمعقود", "probability": 0.80986328125}, {"start": 45.98, "end": 46.36, "word": " عليه", "probability": 0.8701171875}, {"start": 46.36, "end": 46.6, "word": " أي", "probability": 0.90966796875}, {"start": 46.6, "end": 47.12, "word": " المرهون", "probability": 0.84075927734375}, {"start": 47.12, "end": 47.9, "word": " والمرهون", "probability": 0.8707275390625}, {"start": 47.9, "end": 48.08, "word": " به", "probability": 0.70751953125}, {"start": 48.08, "end": 48.28, "word": " اللي", "probability": 0.955810546875}, {"start": 48.28, "end": 48.62, "word": " هو", "probability": 0.9931640625}, {"start": 48.62, "end": 49.18, "word": " الدين", "probability": 0.79248046875}, {"start": 49.18, "end": 50.1, "word": " فسبق", "probability": 0.9690755208333334}, {"start": 50.1, "end": 50.34, "word": " وان", "probability": 0.494873046875}, {"start": 50.34, "end": 50.94, "word": " تحدثنا", "probability": 0.981689453125}, {"start": 50.94, "end": 51.1, "word": " عن", "probability": 0.9951171875}, {"start": 51.1, "end": 51.42, "word": " أول", "probability": 0.96044921875}, {"start": 51.42, "end": 51.72, "word": " رقم", "probability": 0.9069010416666666}, {"start": 51.72, "end": 51.9, "word": " من", "probability": 0.99462890625}, {"start": 51.9, "end": 52.18, "word": " هذه", "probability": 0.95751953125}, {"start": 52.18, "end": 52.6, "word": " الأركان", "probability": 0.9505208333333334}, {"start": 52.6, "end": 52.8, "word": " اللي", "probability": 0.7470703125}, {"start": 52.8, "end": 53.0, "word": " هو", "probability": 0.96142578125}, {"start": 53.0, "end": 53.78, "word": " الصيغة", "probability": 0.988525390625}], "temperature": 1.0}, {"id": 3, "seek": 8318, "start": 54.08, "end": 83.18, "text": "وقلنا إن الصيغة تتمثل في إجابة وقبول من كل من الراهن والمرتهن ولابد فيها من 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{"start": 57.26, "end": 57.64, "word": " كل", "probability": 0.9716796875}, {"start": 57.64, "end": 57.98, "word": " من", "probability": 0.97216796875}, {"start": 57.98, "end": 58.5, "word": " الراهن", "probability": 0.9016927083333334}, {"start": 58.5, "end": 59.2, "word": " والمرتهن", "probability": 0.82568359375}, {"start": 59.2, "end": 59.86, "word": " ولابد", "probability": 0.75732421875}, {"start": 59.86, "end": 60.26, "word": " فيها", "probability": 0.98291015625}, {"start": 60.26, "end": 60.5, "word": " من", "probability": 0.990234375}, {"start": 60.5, "end": 60.96, "word": " الشروط", "probability": 0.88720703125}, {"start": 60.96, "end": 61.44, "word": " العامة", "probability": 0.9871419270833334}, {"start": 61.44, "end": 61.98, "word": " لصيغة", "probability": 0.99267578125}, {"start": 61.98, "end": 62.34, "word": " العقد", "probability": 0.991943359375}, {"start": 62.34, "end": 63.02, "word": " إجمالا", "probability": 0.8865234375}, {"start": 63.02, "end": 64.24, "word": " 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بإذن", "probability": 0.968994140625}, {"start": 77.5, "end": 77.82, "word": " الله", "probability": 0.95703125}, {"start": 77.82, "end": 78.72, "word": " سنكتفي", "probability": 0.849853515625}, {"start": 78.72, "end": 79.34, "word": " بالحديث", "probability": 0.9857177734375}, {"start": 79.34, "end": 79.9, "word": " عن", "probability": 0.9951171875}, {"start": 79.9, "end": 80.44, "word": " الركن", "probability": 0.8583984375}, {"start": 80.44, "end": 81.26, "word": " الثاني", "probability": 0.9658203125}, {"start": 81.26, "end": 81.44, "word": " من", "probability": 0.98779296875}, {"start": 81.44, "end": 81.86, "word": " أركان", "probability": 0.9513346354166666}, {"start": 81.86, "end": 82.24, "word": " عقد", "probability": 0.978515625}, {"start": 82.24, "end": 83.18, "word": " الرهن", "probability": 0.98486328125}], "temperature": 1.0}, {"id": 4, "seek": 11009, "start": 83.53, "end": 110.09, "text": "ألا وهو العاقدان وعاقدي الراهن هما الراهن والمرتهن وبالنسبة للراهن من هو ومن هو المرتهن؟ يلا نشوف مع بعيد من هو الراهن فضل الراهن هو صاحب العين المرهونة ومن عليه الدين برك الله فيك إذا الراهن هو صاحب العين المرهونة", "tokens": [10721, 15040, 37037, 2407, 18863, 995, 28543, 7649, 4032, 3615, 995, 28543, 1829, 34892, 40294, 1863, 8032, 15042, 34892, 40294, 1863, 16070, 29973, 47395, 1863, 46599, 6027, 1863, 35457, 3660, 24976, 23557, 3224, 1863, 9154, 31439, 4032, 27842, 31439, 9673, 43500, 3224, 1863, 22807, 7251, 15040, 8717, 8592, 38688, 20449, 45030, 25708, 9154, 31439, 34892, 40294, 1863, 6156, 11242, 1211, 2423, 23557, 3224, 1863, 31439, 20328, 39319, 3555, 18863, 9957, 9673, 2288, 3224, 11536, 3660, 4032, 27842, 47356, 32748, 9957, 4724, 31747, 21984, 8978, 4117, 11933, 15730, 34892, 40294, 1863, 31439, 20328, 39319, 3555, 18863, 9957, 9673, 2288, 3224, 11536, 3660], "avg_logprob": -0.1769301413613207, "compression_ratio": 2.3719512195121952, "no_speech_prob": 5.960464477539062e-07, "words": [{"start": 83.53, "end": 84.03, "word": "ألا", "probability": 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كما تحدثت قبل قليل حول هذه الأركان أقول قولي هذا واستغفر الله لي ولكم وصل اللهم وسلم مبارك على سيدنا محمد والسلام عليكم ورحمة الله تعالى وبركاته", "tokens": [6027, 7578, 34105, 8717, 30544, 12174, 3215, 16472, 47395, 1829, 8315, 9154, 3714, 2407, 11242, 45367, 3714, 5016, 46958, 43500, 8315, 46740, 15730, 45595, 20498, 9673, 5016, 46958, 25720, 25062, 18513, 46007, 4724, 28814, 8848, 1863, 21984, 8608, 1863, 24793, 1211, 9122, 15042, 6055, 24401, 12984, 2655, 12174, 36150, 12174, 20292, 1211, 11331, 12610, 29538, 16247, 31747, 7649, 5551, 39648, 12174, 12610, 1829, 23758, 36764, 14851, 17082, 5172, 2288, 21984, 32239, 4032, 23275, 2304, 4032, 36520, 13672, 16095, 46952, 19528, 3714, 3555, 9640, 4117, 15844, 8608, 25708, 8315, 3714, 35571, 3215, 16070, 3794, 37440, 25894, 24793, 4032, 2288, 35571, 3660, 21984, 37279, 6027, 7578, 4032, 26890, 4117, 9307, 3224], "avg_logprob": -0.08735795556144281, "compression_ratio": 1.9220183486238531, "no_speech_prob": 0.0008015632629394531, "words": 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" هذا", "probability": 0.94775390625}, {"start": 875.8, "end": 876.36, "word": " واستغفر", "probability": 0.853857421875}, {"start": 876.36, "end": 876.52, "word": " الله", "probability": 0.8876953125}, {"start": 876.52, "end": 876.7, "word": " لي", "probability": 0.912109375}, {"start": 876.7, "end": 877.52, "word": " ولكم", "probability": 0.9353841145833334}, {"start": 877.52, "end": 878.02, "word": " وصل", "probability": 0.6956787109375}, {"start": 878.02, "end": 878.38, "word": " اللهم", "probability": 0.915283203125}, {"start": 878.38, "end": 878.82, "word": " وسلم", "probability": 0.7509765625}, {"start": 878.82, "end": 879.2, "word": " مبارك", "probability": 0.841796875}, {"start": 879.2, "end": 879.42, "word": " على", "probability": 0.8623046875}, {"start": 879.42, "end": 879.98, "word": " سيدنا", "probability": 0.9944661458333334}, {"start": 879.98, "end": 880.62, "word": " محمد", "probability": 0.9913736979166666}, {"start": 880.62, "end": 881.48, "word": " والسلام", 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/Pf2-Yp-1DUg_postprocess.srt b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/Pf2-Yp-1DUg_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..fd25c3d3adfe8a946b796a38f81d6dd45834bbd9
--- /dev/null
+++ b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/Pf2-Yp-1DUg_postprocess.srt
@@ -0,0 +1,672 @@
+1
+00:00:05,600 --> 00:00:08,300
+أعوذ بالله السميع العلي من الشيطان الراجيم بسم
+
+2
+00:00:08,300 --> 00:00:11,560
+الله الرحمن الرحيم الحمد لله رب العالمين والصلاة
+
+3
+00:00:11,560 --> 00:00:14,940
+والسلام على أشرف الأنبياء والمرسلين سيدنا محمد بن
+
+4
+00:00:14,940 --> 00:00:18,400
+عبد الله الصادق الأمين ثم أما بعد أحييكم جميعا
+
+5
+00:00:18,400 --> 00:00:21,560
+بتحية الإسلام في السلام عليكم ورحمة الله تعالى
+
+6
+00:00:21,560 --> 00:00:27,460
+وبركاته كيف حالة كنا طيبات ان شاء الله تحضيرنا جيد
+
+7
+00:00:27,460 --> 00:00:32,730
+ان شاء اللهطيب عظيم إذا المحاضرة السابقة كنا قد
+
+8
+00:00:32,730 --> 00:00:37,150
+شرعنا بالحديث عن مفهوم الربا وعرفنا أن الربا عبارة
+
+9
+00:00:37,150 --> 00:00:41,090
+عن عقد على عوض مخصوص غير معلوم التماثل في معيار
+
+10
+00:00:41,090 --> 00:00:44,950
+الشرعيحالة العقدي أو ما تأخير في أحد البدلين أو
+
+11
+00:00:44,950 --> 00:00:50,710
+كليهما فهذا التعريففهمنا منه أمرا مفاده أن الربا
+
+12
+00:00:50,710 --> 00:00:55,290
+لا يكون في جميع الأموال بل إنه يكون في عوض مخصوص
+
+13
+00:00:55,290 --> 00:01:01,070
+أي في أموال معينة أي في أموال مخصوصة ومحددة تعرف
+
+14
+00:01:01,070 --> 00:01:04,890
+بالأموال الربوية وهذا ما سنتحدث عنه في هذه
+
+15
+00:01:04,890 --> 00:01:10,190
+المحاضرة فلحظي معايايعني لما بنتحدث عن ربا مش
+
+16
+00:01:10,190 --> 00:01:14,090
+معناته ان الربا يعم و يشمل جميع الأموال بل ان
+
+17
+00:01:14,090 --> 00:01:18,110
+الربا كما قلت قبل قليل يكون في أموال معينة و أموال
+
+18
+00:01:18,110 --> 00:01:22,630
+مخصوصة هذه الأموال تعرف بالأموال الرباوية وقد
+
+19
+00:01:22,630 --> 00:01:28,350
+حددها سيدنا النبي صلى الله عليه وسلم بستة أصناف
+
+20
+00:01:28,350 --> 00:01:43,310
+تتمثل في الذهب و الفضةو القمح والشعير والتمر
+
+21
+00:01:43,310 --> 00:01:49,510
+والملح الآن يا جماعة حينما نقول أن الأموال الربوية
+
+22
+00:01:49,510 --> 00:01:55,610
+تنحصر في الأموال الستة التي حددها نبينا صلى الله
+
+23
+00:01:55,610 --> 00:02:01,570
+عليه وسلم هذا يعني أن ما ليس من هذه الأموال وما
+
+24
+00:02:01,570 --> 00:02:07,380
+ليس مالا ربويا لا يدخله الربالكن الآن السؤال اللي
+
+25
+00:02:07,380 --> 00:02:11,060
+بيطرح نفسه أنه هل هي تُرى الأموال الربوية فقط هي
+
+26
+00:02:11,060 --> 00:02:17,220
+ست أموال هذه أم يلحق بها غيرها بما يماثلها من
+
+27
+00:02:17,220 --> 00:02:22,160
+علتها أو في علتها سنجد أن هناك خلاف بين الفقهاء
+
+28
+00:02:22,160 --> 00:02:29,320
+الظاهرية يرونأن الأموال الربوية تنحصر فقط في الست
+
+29
+00:02:29,320 --> 00:02:34,960
+أصناف التي حددها النبي صلى الله عليه وسلم بس اللي
+
+30
+00:02:34,960 --> 00:02:38,300
+حددوا النبي هو ست أصناف إذا الأموال الربوية بس ست
+
+31
+00:02:38,300 --> 00:02:42,740
+أصناف عاملا بظاهر حديث نبينا صلى الله عليه وسلم
+
+32
+00:02:42,740 --> 00:02:46,280
+والأحاديث التي تدل على هذه الأموال يلا سريعا ناخد
+
+33
+00:02:46,280 --> 00:02:52,040
+الأحاديث قبل ما ناخد الرأي التاني والباقي جاوب
+
+34
+00:02:52,040 --> 00:02:58,280
+لرفعين إيداهم اتفضلي اهأنا واحد في خليمة مسلمة عن
+
+35
+00:02:58,280 --> 00:03:02,500
+عمر بن الخطاب رضي الله عنه قال قال رسول الله صلى
+
+36
+00:03:02,500 --> 00:03:07,980
+الله عليه وسلم ذهب بالذهب ربا إلا ها أن وها و البر
+
+37
+00:03:07,980 --> 00:03:13,220
+بالبر بر بر فيه بر و فيه بر و فيه بر صح طيب اتفضل
+
+38
+00:03:13,220 --> 00:03:18,680
+و البر بالبر ربا إلا ها أن وها و الشعير بالشعير
+
+39
+00:03:18,680 --> 00:03:22,660
+ربا إلا ها أن وها و التمر بالتمر ربا إلا ها أن وها
+
+40
+00:03:22,660 --> 00:03:27,930
+و في رواية مخرج الورقالورق فبعثوا واحدكم بورقكم
+
+41
+00:03:27,930 --> 00:03:35,510
+هذا بارك الله فيك اذا اول حديث يدل على هذه الاموال
+
+42
+00:03:35,510 --> 00:03:40,170
+مروية ان النبي صلى الله عليه وسلم يقول الذهب
+
+43
+00:03:40,170 --> 00:03:45,610
+بالذهب ربا الا ها وها يدا بيد يعني ها تمام الا ها
+
+44
+00:03:45,610 --> 00:03:50,170
+وهاوالبر بالبر ربا إلا ها وها والشعير بالشعير ربا
+
+45
+00:03:50,170 --> 00:03:53,730
+إلا ها وها والتمر بالتمر ربا إلا ها وها وفي رواية
+
+46
+00:03:53,730 --> 00:03:58,370
+أخرى قال صلى الله عليه وسلم والورق بالورق ربا إلا
+
+47
+00:03:58,370 --> 00:04:04,050
+ها وها الورق اللي هو الفضةلأنه ورد في صورة الكهف
+
+48
+00:04:04,050 --> 00:04:08,650
+اللي كلكم تقرؤوها اللي هو فابعثوا أحدكم بوريقكم
+
+49
+00:04:08,650 --> 00:04:12,630
+هذه إلى المدينة النقود كانت النقود قديما يا دنار
+
+50
+00:04:12,630 --> 00:04:20,170
+يا درهم اللي هو فضة أو ذهب تمام أيضا حديث أخر يدله
+
+51
+00:04:20,170 --> 00:04:22,450
+ويشمل هذه الأصناف الست يا سماح
+
+52
+00:04:27,620 --> 00:04:31,400
+والبنو بالبنو و الشعير بالشعير و الثهر بالثهر و
+
+53
+00:04:31,400 --> 00:04:36,040
+الملح بالملح فبمثل يدرية فمن دادة أو أسدادة فقد
+
+54
+00:04:36,040 --> 00:04:42,200
+أكبربرك الله فيك إذا يقول صلى الله عليه وسلم الذهب
+
+55
+00:04:42,200 --> 00:04:46,320
+بالذهب و الفضة بالفضة و البر بالبر و الشاير
+
+56
+00:04:46,320 --> 00:04:51,640
+بالشاير و التمر بالتمر و الملح بالملح مثلا بمثل
+
+57
+00:04:51,640 --> 00:04:57,380
+يدا بيد فمن زاد أو استزاد فقد أربى الآخذ و المعطي
+
+58
+00:04:57,380 --> 00:05:04,250
+فيه سواءتمام؟ فلحظي الحديثين هذين بينا لنا بعيدا
+
+59
+00:05:04,250 --> 00:05:07,990
+عن الأحكام اللي لسه مش راح نحكي فيها الآن بينا لنا
+
+60
+00:05:07,990 --> 00:05:11,750
+شو هي الأموال الربوية فمن هنا نشأ الخلاف بين
+
+61
+00:05:11,750 --> 00:05:16,790
+العلماء فالظاهرية عملوا بظاهر هذا الحديث واقتصروا
+
+62
+00:05:16,790 --> 00:05:21,810
+على الأصناف الستة التي حددها النبي صلى الله عليه
+
+63
+00:05:21,810 --> 00:05:27,430
+وسلمبينما جمهور العلماء من الأئمة الأربعة وأكثر
+
+64
+00:05:27,430 --> 00:05:30,850
+أهل العلم اللي هم حنفية، مالكية، شفعية، حنابل أو
+
+65
+00:05:30,850 --> 00:05:35,450
+أكثر أهل العلم ذهبوا إلى أن الأموال الربوية لا
+
+66
+00:05:35,450 --> 00:05:42,690
+تقتصر على الستة أصنات بل يلحقوا بها كل ما مثلها في
+
+67
+00:05:42,690 --> 00:05:48,990
+علتهاكل شيء أو كل مال يشترك مع هذه الأموال في
+
+68
+00:05:48,990 --> 00:05:54,530
+الإلة كان مالا رباويا حلو فلمّا اجوا قالولنا هذا
+
+69
+00:05:54,530 --> 00:06:00,120
+الكلام روحنا قلنا لهم طب شو هي إلة الربا؟شو هي
+
+70
+00:06:00,120 --> 00:06:04,340
+العلة في هذه الأموال فقبل ما يجاوبونا أو قبل ما
+
+71
+00:06:04,340 --> 00:06:08,460
+احنا نجاوب سنجد ان هؤلاء العلماء اللي اتفجوا انه
+
+72
+00:06:08,460 --> 00:06:12,540
+في أموال تانية تلحق بالأموال الستة اختلفوا في علة
+
+73
+00:06:12,540 --> 00:06:16,820
+الربا اختلفوا اشي جال العلة الوزن اشي جال العلة
+
+74
+00:06:16,820 --> 00:06:21,540
+القوت اشي جال العلة كذا كذا كذا نحن سنعتمد على رأي
+
+75
+00:06:21,540 --> 00:06:28,590
+الشافعية هنا القاضي بأن العلة في هذه الأموالهي
+
+76
+00:06:28,590 --> 00:06:33,570
+الثمانية والمطعمية وقبل ما نحدد هذا الكلام نعرف
+
+77
+00:06:33,570 --> 00:06:40,610
+علّة الربا يلا علّة الربا شو يعني علّة الربا اتفضل
+
+78
+00:06:40,610 --> 00:06:45,050
+الوصف اللذي ضروري بالمال كان المال رباوية اذا بارك
+
+79
+00:06:45,050 --> 00:06:51,690
+الله فيك بنقول الربا الربا
+
+80
+00:06:51,690 --> 00:06:56,350
+عبارة عن الوصف الذي
+
+81
+00:06:58,170 --> 00:07:09,770
+إذا وجد في المال كان المال مالا ربويا في لحظة
+
+82
+00:07:09,770 --> 00:07:14,950
+معايا قلة الربا هي الوصف وصف معين موجود في هذا
+
+83
+00:07:14,950 --> 00:07:19,290
+المال فإذا وجد في أي مال آخر كان هذا المال مال
+
+84
+00:07:19,290 --> 00:07:23,870
+ربوي بناء على وجود الوصف هنا وهنا طب شو هي الإلة
+
+85
+00:07:23,870 --> 00:07:26,670
+الشفقية قالوا الإلة إما ثمانية
+
+86
+00:07:29,500 --> 00:07:34,120
+أو مطعمية طبعا
+
+87
+00:07:34,120 --> 00:07:40,020
+نقصد بالمطعمية تعامل آدممديش حد يسألني شو يعني
+
+88
+00:07:40,020 --> 00:07:43,460
+آدمي، طالبة بتقولي شو يعني آدمي؟ قولت لأ والله هذه
+
+89
+00:07:43,460 --> 00:07:49,180
+كبيرة، تمام، شو يعني آدمي؟ مطعم لآدمي، طعام لآدمي،
+
+90
+00:07:49,180 --> 00:07:53,140
+خليكم معايا لحظة معايا، لما نظرنا في الأصناف
+
+91
+00:07:53,140 --> 00:07:57,340
+الستة، مالاجيناش الأموال الستة هذه كلها مثل بعضها،
+
+92
+00:07:57,340 --> 00:08:01,500
+حتى نوجد إلا واحدة إلها، لاجينا في إنا دهب وفضة
+
+93
+00:08:02,200 --> 00:08:05,440
+فبالتأكيد مشبهوش القمح و الشقير و التمر و الملح
+
+94
+00:08:05,440 --> 00:08:11,240
+فروحنا سألنا أنفسنا احنا كعلماء مش انا يعني هم طيب
+
+95
+00:08:11,240 --> 00:08:16,760
+حينما كانوا يضعون حكما او ضابطا او معيارا للشيء
+
+96
+00:08:16,760 --> 00:08:22,420
+يعملون اراءهم يتأملون يفكرون يتدبرون حتى يخرجوا
+
+97
+00:08:22,420 --> 00:08:28,860
+بالحكم المعين فنظروا الذهب و الفضة فوجدوا ان الذهب
+
+98
+00:08:28,860 --> 00:08:33,170
+و الفضة ما هي الا أثمان للاشياءلأنه كما قلت قبل
+
+99
+00:08:33,170 --> 00:08:38,210
+قليل العملات أو الدراهم أو النقود قديما كانت دهم
+
+100
+00:08:38,210 --> 00:08:43,010
+وفضة دينار ودرهم بس لا كان فيه يورو ولا شكل ولا
+
+101
+00:08:43,010 --> 00:08:49,210
+شيء كل العملات اللي اليوم ما هي إلا رموزرموز بدليل
+
+102
+00:08:49,210 --> 00:08:52,750
+إنه بتنهار في أي لحظة في أي لحظة ممكن تلاقي
+
+103
+00:08:52,750 --> 00:08:58,850
+الدولار خلاص انمحى مثلا فهو يعني شغلة رمزية بخلاف
+
+104
+00:08:58,850 --> 00:09:03,910
+الذهب والفضة فنرجع نقول الذهب والفضة قلتهم إنهم
+
+105
+00:09:03,910 --> 00:09:08,050
+أثمان بينما القمح والشعير والتمر والملح قلتهم إنهم
+
+106
+00:09:08,050 --> 00:09:13,470
+مطعمات لآدمي ولحظة لما قلت مطعمات لآدميحتى أقولك
+
+107
+00:09:13,470 --> 00:09:16,950
+الأعلاف مش أموال ربوية لأنها وإن كانت مطعمات إلا
+
+108
+00:09:16,950 --> 00:09:21,910
+إنها مطعمات لغير الآدم تمام ني جينجول فالآن حينما
+
+109
+00:09:21,910 --> 00:09:26,370
+أتحدث عن علة الذهب والفتة جن السمنية شو معنى هذا
+
+110
+00:09:26,370 --> 00:09:31,350
+الكلام؟ معناته أن كل ما مثلها في علتها كان مالا
+
+111
+00:09:31,350 --> 00:09:36,050
+ربويا فكل النقود الدرجة اليوم على اختلافها تعتبر
+
+112
+00:09:36,050 --> 00:09:42,030
+أموال ربوية بيدخل في ذلك الشكل الدولار الدينار
+
+113
+00:09:43,870 --> 00:09:50,010
+الـ Lira لجنيه لريال و .. و .. كل العملات الدارجة
+
+114
+00:09:50,010 --> 00:09:55,130
+اللي الناس بتتعامل بيها تعتبر أموال ربوية و لحظي
+
+115
+00:09:55,130 --> 00:10:00,730
+معايا حينما أقول إن هذه الأموال أموال ربوية هذا لا
+
+116
+00:10:00,730 --> 00:10:05,630
+يعني أنه لا يجوز لي أن أتعامل بيها لأ معناته إن
+
+117
+00:10:05,630 --> 00:10:12,200
+أردت أن أتعامل بيها يجب أن يكون التعامل وفقهشروط
+
+118
+00:10:12,200 --> 00:10:16,900
+وضوابط خاصة تضاف للشروط العامة للبيع إجمالا علم
+
+119
+00:10:16,900 --> 00:10:22,540
+نيجي الأن أيضا للمطعمات قلنا كل ما يعد طعاما
+
+120
+00:10:22,540 --> 00:10:28,540
+لأدمين كان مالا ربويا وبالتالي بيدخل في ذلك مثلا
+
+121
+00:10:28,540 --> 00:10:38,640
+الرز العدس حاضركمان اللحوم اللحوم الأسماك بيدخل
+
+122
+00:10:38,640 --> 00:10:43,360
+مثلا البيض تدخل الفاكهة لأن العلماء لما أجوا
+
+123
+00:10:43,360 --> 00:10:47,880
+يفندوا هذه الأموال قالك القمح والشعير تمثل قوتا
+
+124
+00:10:47,880 --> 00:10:55,330
+للناس بتمثل قوت و أي شيء يمثل قوت إذا ما الربويطيب
+
+125
+00:10:55,330 --> 00:11:00,350
+التمر يمثلوا يعني عادة الناس بيأخذوه للتفكه كفاكهة
+
+126
+00:11:00,350 --> 00:11:05,550
+فكل ما مثله يعد مالا ربويا فكل الفواكه أموال ربوية
+
+127
+00:11:05,550 --> 00:11:09,230
+على مذهب الشفائية طبعا الحنافية أو المالكية
+
+128
+00:11:09,230 --> 00:11:14,450
+بيقولوا لأ فرقوا فصلوا مش موضوع حديثين أولا نتطرق
+
+129
+00:11:14,450 --> 00:11:20,350
+لهذا الخلاف في هذا المساق يعني موضوع الملح الملح
+
+130
+00:11:20,350 --> 00:11:24,630
+عادة لإصلاح الطعامعشان كده الأكل اللي ماعلوش ملح
+
+131
+00:11:24,630 --> 00:11:27,330
+إش بنقول على طول أول كلمة بنقولها زي أكل العيانين
+
+132
+00:11:27,330 --> 00:11:32,090
+صح ولا لأ؟ بنقولها زي أكل المستشفى زي أكل كذا فإذا
+
+133
+00:11:32,090 --> 00:11:36,890
+الملح للتداوي لإصلاح الطعام فكل ما كان لإصلاح
+
+134
+00:11:36,890 --> 00:11:40,130
+الطعام و للتداوي كان ملر ربويا بيدخل في ذلك كل
+
+135
+00:11:40,130 --> 00:11:44,850
+أنواع التوابلتوابل كلها لأنه ممكن طبخة عليها ملح
+
+136
+00:11:44,850 --> 00:11:48,210
+ومع ذلك نحس مالهااش طعم لأنه ناجسها كذا كذا
+
+137
+00:11:48,210 --> 00:11:50,830
+إبهارات معينة الإبهارات الخاصة بالأكلة الفلانية
+
+138
+00:11:50,830 --> 00:11:54,930
+مثلا وبناء على ذلك جالك أن حتى التوابل تعتبر من
+
+139
+00:11:54,930 --> 00:11:59,590
+الأموال الربوية فكل ما كان تعامل لأدمين كان مالا
+
+140
+00:11:59,590 --> 00:12:03,750
+ربويا واللحظة يا جماعة بأكد أن هذا الكلام اللي أنا
+
+141
+00:12:03,750 --> 00:12:07,560
+بحكيها ال gate ليس متفقا عليهليس متفق عليه بس هذا
+
+142
+00:12:07,560 --> 00:12:11,340
+اللي انت مطالبة فيه تمام كمثاق لأن احنا ال gate
+
+143
+00:12:11,340 --> 00:12:14,540
+يعني مش معنية ندرس كل الأقوال العلماء في ذات
+
+144
+00:12:14,540 --> 00:12:18,540
+المسألة في مساقات فقه مقارن وكذا بتدرسوا هذه
+
+145
+00:12:18,540 --> 00:12:22,500
+الأمور بالتفصيل لكن نحن في هذا المساق نكتفي بهذا
+
+146
+00:12:22,500 --> 00:12:26,500
+القدر طيب
+
+147
+00:12:28,760 --> 00:12:33,200
+بنان على ذلك يا جماعة لحظة معايا كل ما كان ثمنا
+
+148
+00:12:33,200 --> 00:12:36,700
+كان مالا ربويا كل ما كان طعاما لأدمين كان مالا
+
+149
+00:12:36,700 --> 00:12:44,160
+ربويا يفهم من ذلك ان ما لا يعد ثمنا للأشياء و ما
+
+150
+00:12:44,160 --> 00:12:48,980
+لا يعد طعاما لأدمين لا يعد مالا ربويا ممكن تقولي
+
+151
+00:12:48,980 --> 00:12:52,300
+ما هو ايش ضال ما انت حكيت كل حاجة بقولك لا ضال
+
+152
+00:12:52,300 --> 00:12:56,890
+الملابسجلبابي وجلبابك مش ماربوي لأ بناكله ولا
+
+153
+00:12:56,890 --> 00:13:00,070
+بناخد الجلباب و بنروح ع المول نقوله لو سمحت اعطيني
+
+154
+00:13:00,070 --> 00:13:06,090
+شوكولاتة لأ أبدا نفس الشيء السيارات الجوالات
+
+155
+00:13:06,090 --> 00:13:09,350
+الأراضي الحيوانات ما تقوليلي عن الحيوان ما هو لا
+
+156
+00:13:09,350 --> 00:13:13,380
+حاجةلأ الضحى بيصير لحمة بيصير مال رباوي و هو كده
+
+157
+00:13:13,380 --> 00:13:19,280
+زي هو بيقول معه باع فبيقول مش مال رباوي فالأراضي
+
+158
+00:13:19,280 --> 00:13:23,960
+الدور السيارات الجوالات الطاولة الأثاث و كل هذه
+
+159
+00:13:23,960 --> 00:13:28,060
+الأمور لا تعدوا أموالا رباويافانت دائما عشان تريح
+
+160
+00:13:28,060 --> 00:13:32,240
+راسك امشي على الضابط ثمن ولا مش ثمن؟ طعام ولا مش
+
+161
+00:13:32,240 --> 00:13:37,980
+طعام؟ اذا ثمن مال ربوي، مش ثمن يمكن تعام، هو مش
+
+162
+00:13:37,980 --> 00:13:42,020
+ثمن لكنه طعام، مال ربوي، طب لا ثمن ولا طعام ليس
+
+163
+00:13:42,020 --> 00:13:47,700
+مالا ربويا علم واضح هذا بالنسبة لعلتي الربا
+
+164
+00:13:47,700 --> 00:13:52,840
+المحاضرة القادمة بإذن الله سنتحدث سويا حول أنواع
+
+165
+00:13:52,840 --> 00:13:56,590
+الرباالى هنا نكون قد انتهينا من موضوع محاضرتنا
+
+166
+00:13:56,590 --> 00:14:00,850
+أقول قولي هذا وأستغفر الله لي ولكم وصل اللهم وسلم
+
+167
+00:14:00,850 --> 00:14:04,670
+وبارك على سيدنا محمد والسلام عليكم ورحمة الله
+
+168
+00:14:04,670 --> 00:14:05,110
+تعالى
+
diff --git a/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/QmV_rp9DmF8.srt b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/QmV_rp9DmF8.srt
new file mode 100644
index 0000000000000000000000000000000000000000..9892482c4b16d212e8686e020d32b63b3acfe380
--- /dev/null
+++ b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/QmV_rp9DmF8.srt
@@ -0,0 +1,971 @@
+1
+00:00:05,570 --> 00:00:08,550
+أعوذ بالله من الشيطان الرجيم بسم الله
+
+2
+00:00:08,550 --> 00:00:11,710
+الرحمن الرحيم الحمد لله رب العالمين والصلاة
+
+3
+00:00:11,710 --> 00:00:15,390
+والسلام على أشرف الأنبياء والمرسلين سيدنا محمد بن
+
+4
+00:00:15,390 --> 00:00:19,010
+عبد الله الصادق الأمين، ثم أما بعد، أحييكم جميعا
+
+5
+00:00:19,010 --> 00:00:22,710
+بتحية الإسلام، فالسلام عليكم ورحمة الله تعالى
+
+6
+00:00:22,710 --> 00:00:27,860
+وبركاته، كيف حالكم؟ طيبات إن شاء الله؟ تحضيرنا جيد
+
+7
+00:00:27,860 --> 00:00:32,220
+إن شاء الله؟ عظيم، إذا كنا قد تحدثنا في المحاضرة
+
+8
+00:00:32,220 --> 00:00:36,140
+السابقة عن الركن الثالث من أركان الرهن، وهو
+
+9
+00:00:36,140 --> 00:00:39,740
+المرهون، قلنا إن المرهون لابد أن يكون عينا، على
+
+10
+00:00:39,740 --> 00:00:43,800
+الراجح، فلا يصح رهن الدين. أيضا تحدثنا عن أنه لا
+
+11
+00:00:43,800 --> 00:00:48,040
+يصح رهن المنفعة. ثم انتهينا بالحديث عن رهن المشاع
+
+12
+00:00:48,040 --> 00:00:54,070
+وقلنا بجواز رهنه، لكن بالنسبة لتسليمه للمرتهن، مرتبط
+
+13
+00:00:54,070 --> 00:01:01,170
+أو مرتبط بإذن الشريك، فإن أذنه جاز، وإلا فيقوم
+
+14
+00:01:01,170 --> 00:01:06,190
+الشريك مقام المرتهن إن رضيه، وإلا فيعين القاضي
+
+15
+00:01:06,190 --> 00:01:11,070
+وصيا على المشاع. اليوم بإذن الله سنتحدث عن رهن ما
+
+16
+00:01:11,070 --> 00:01:17,180
+يسرع إليه الفساد. وفي هذه المسألة بالتأكيد الأمثلة
+
+17
+00:01:17,180 --> 00:01:22,100
+هي التي ستوضح هذه المسألة، والأمثلة التي سنستخدمها
+
+18
+00:01:22,100 --> 00:01:26,400
+أمثلة افتراضية ليست إلا، يعني ربما مش هتكون منطقية
+
+19
+00:01:26,400 --> 00:01:30,940
+كثيرا، لكن المهم الهدف والغاية من هذه الأمثلة، وأن
+
+20
+00:01:30,940 --> 00:01:36,890
+هذا التمثيل هو تقريب الصورة إلى حد كبير. فأنا هنا
+
+21
+00:01:36,890 --> 00:01:41,750
+أتحدث عن رهن ما يسرع إليه الفساد، زي لحم، زي خضار،
+
+22
+00:01:41,750 --> 00:01:45,590
+فاكهة، هذه الأمور يسرع إليها الفساد، تمام؟ حلو، هل
+
+23
+00:01:45,590 --> 00:01:49,770
+يجوز رهنها أم لا؟ بنقول ونفرق ابتداء، بينما إذا
+
+24
+00:01:49,770 --> 00:01:55,940
+أمكن حفظ هذه الأمور أم لا، يعني نقول ابتداء إذا
+
+25
+00:01:55,940 --> 00:02:02,440
+أمكن حفظ ما يسرع إليه الفساد، حينها يجوز ويصح الرهن
+
+26
+00:02:02,440 --> 00:02:08,460
+وتكون تكاليف الحفظ على الراهن. يعني بنفترض جدلا أنا
+
+27
+00:02:08,460 --> 00:02:14,800
+روحت اتدينت مبلغ من المال، وليكن ألف دولار، طلب مني
+
+28
+00:02:14,800 --> 00:02:19,840
+رهن، أنا لحم أو جزار، قلت له بدي أرهن عندك ثلاثين
+
+29
+00:02:19,840 --> 00:02:25,300
+كيلو لحمة، اللحمة يسرع إليها الفساد الطبيعي، يمكن
+
+30
+00:02:25,300 --> 00:02:29,440
+حفظها أم لا؟ اه، بالتبريد والتشفيف، فما في مشكلة
+
+31
+00:02:29,440 --> 00:02:34,890
+فالآن تعرفوا التجار بيكون لهم ثلاجات خاصة، مش زي ثلاجة
+
+32
+00:02:34,890 --> 00:02:40,610
+البيت، صح ولا لأ؟ فالآن ممكن هو، بدنا نستأجر ثلاجة
+
+33
+00:02:40,610 --> 00:02:45,210
+لتبريد اللحمة، نحط اللحمة فيها لمدة الدين، ممكن مدة
+
+34
+00:02:45,210 --> 00:02:48,970
+الدين ستة أشهر، أكثر، أقل، بغض النظر إيش هي المدة،
+
+35
+00:02:48,970 --> 00:02:55,730
+طالما أنت محافظها، فيصح رهنه، وأي تكاليف، أجرة الثلاجة،
+
+36
+00:02:55,730 --> 00:03:00,080
+مثلا، الكهربا، كذا، كلها على مين؟ على الراهن، الطبيعي
+
+37
+00:03:00,080 --> 00:03:04,160
+لأنه ما له علاقة المرتهن بالموضوع، يتفا من جابه ولا
+
+38
+00:03:04,160 --> 00:03:10,250
+شاكر، أنا مدينك، أنا واقف جنبك، أنا مساعدك، حجي أضمن
+
+39
+00:03:10,250 --> 00:03:13,610
+فلوسي ترجع لي، طلبت منك تروح تقول لي أنا حاينب درهم
+
+40
+00:03:13,610 --> 00:03:17,870
+اللحم، وتدبر حالك، وانت تحطها، لأ، هذه مسؤوليتك أنت،
+
+41
+00:03:17,870 --> 00:03:23,490
+تكاليف الحفظ، احفظها على حسابك، لأن أنا بس اللي بدي
+
+42
+00:03:23,490 --> 00:03:27,750
+أتأكد فلوسي ترجع لي أم لا. إذا في هذه الحالة، إذا
+
+43
+00:03:27,750 --> 00:03:35,750
+أمكن حفظ ما يسرع إليه الفساد، بنقول: يا صح الرهن، و
+
+44
+00:03:35,750 --> 00:03:44,340
+يُغرم المالك تكاليف الحفظ. تكاليف الحفظ على مين؟ على
+
+45
+00:03:44,340 --> 00:03:50,360
+الراهن، اللي هو بنقول عنه المالك، مش هو الذي يملك
+
+46
+00:03:50,360 --> 00:03:56,940
+المرهون، تمام، واضح، مش فيها أي إشكالية. بينما لو كان
+
+47
+00:03:56,940 --> 00:04:02,080
+ما يسرع إليه الفساد لا يمكن حفظه، بدي أجيب مثال، ومش
+
+48
+00:04:02,080 --> 00:04:05,080
+كتير منطقي، البندورة مثلا، البندورة يمكن حفظها، بس
+
+49
+00:04:05,080 --> 00:04:10,610
+بدنا نفترضها، بدنا نفترض أنه لا يمكن حفظها، تمام؟ لأن
+
+50
+00:04:10,610 --> 00:04:13,750
+البندورة بنعملها سلسة، بنحطها... في ناس بيحطوها
+
+51
+00:04:13,750 --> 00:04:16,930
+بالفريزر، في ناس بتجففها بالشمس، بتحط عليها ملح،
+
+52
+00:04:16,930 --> 00:04:20,450
+بتحطها بمرطبانات وبتستخدمها، فهذا كلها وسائل حفظ
+
+53
+00:04:20,450 --> 00:04:24,350
+موجودة، لكن أنا بدي أفترض هذه الوسائل مش موجودة،
+
+54
+00:04:24,350 --> 00:04:27,450
+يعني لا يمكن حفظها، تمام؟ يعني هذا الكلام قصته،
+
+55
+00:04:27,450 --> 00:04:31,270
+عملوله كذا، إنتوا اللي عملتوا له كذا، تمام؟ حلو، نيجي
+
+56
+00:04:31,270 --> 00:04:36,120
+الآن لما لا يمكن حفظه، ما يسرع إليه الفساد ولا
+
+57
+00:04:36,120 --> 00:04:40,860
+يمكن حفظه، كالطماطم مثلا، مثال افتراضي هنا، نفرق
+
+58
+00:04:40,860 --> 00:04:46,180
+ابتداء بين شغلتين، أنه هل يا ترى هذا الذي يسرع إليه
+
+59
+00:04:46,180 --> 00:04:51,220
+الفساد ولا يمكن حفظه، رهن بدين حال أم بدين مؤجل؟
+
+60
+00:04:51,220 --> 00:05:00,480
+قلنا: إذا رهن بدين حال، فيصح الرهن، ها يصح
+
+61
+00:05:03,070 --> 00:05:07,390
+الرهن، ما في مشكلة، لأنه الهدف إيش؟ أني أستوثق حقي،
+
+62
+00:05:07,390 --> 00:05:13,230
+يعني مثال، خليكم معي، أنا كنت مديونة، كنت مديونة
+
+63
+00:05:13,230 --> 00:05:19,270
+مبلغ من المال، الدائن جاء لي، ما في مشكلة، تفضلي، و باسي
+
+64
+00:05:19,270 --> 00:05:24,950
+بشرط أنك ترجعي لي الفلوس بـ15/5، اليوم، خمسة عشر خمسة
+
+65
+00:05:24,950 --> 00:05:30,690
+كان الدين له فترة، قال لي: ارجعي لي بخمسة عشر خمسة، وولا
+
+66
+00:05:30,690 --> 00:05:34,850
+طلب مني رهن ولا شيء، حلو، جاءني بخمسة عشر خمسة، ياخد
+
+67
+00:05:34,850 --> 00:05:40,450
+فلوسه، قلت له: أنا عند كلامي، بس العصر بدها تجيني
+
+68
+00:05:40,450 --> 00:05:44,230
+حوالة مالية، وولا ما عندي أي مشكلة، الدين حال، فقال بس
+
+69
+00:05:44,230 --> 00:05:49,310
+العصر حا أعطيكي إياه. جاء لي، ماشي، بس بدي رهن، ها دين
+
+70
+00:05:49,310 --> 00:05:55,510
+حال، وطلب رهن مقابل هذا الدين، ولما بقول لك دين حال،
+
+71
+00:05:55,510 --> 00:05:58,410
+يعني من حقه كمان ساعة، ساعتين، يجي يجبرني على الدفع
+
+72
+00:05:58,410 --> 00:06:03,720
+وإلا يحبسني، من حقه، لأنه مش مؤجل الدين. فانا هو قال
+
+73
+00:06:03,720 --> 00:06:06,340
+لا بدي أحبسكي ولا شيء، بدي رهن، ده أتأكد إن العصر
+
+74
+00:06:06,340 --> 00:06:09,720
+فعلا تجيني فلوسي أم لا، قلت له: يا عم، هي البندورة، و
+
+75
+00:06:09,720 --> 00:06:13,040
+البندورة غالية اليومها مثلا، هي البندورة بدي أرهنها
+
+76
+00:06:13,040 --> 00:06:16,560
+مقابل الدين، قال له: ماشي خلاص. فالآن البندورة
+
+77
+00:06:16,560 --> 00:06:20,240
+يسرع إليها الفساد، لا يمكن حفظها، ومع ذلك، هل يجوز، و
+
+78
+00:06:20,240 --> 00:06:24,960
+يصح رهنها؟ نعم، ليش؟ للدين حال، يعني لن تفسد، يعني بقدر
+
+79
+00:06:24,960 --> 00:06:29,920
+أنا أبيعها وآخذ فلوسي، لو ما دفع لي، علم؟ تمام؟ حلو
+
+80
+00:06:31,480 --> 00:06:41,700
+هذا إذا رهن بدين حال، أو ما يسرع إليه الفساد ولا
+
+81
+00:06:41,700 --> 00:06:49,700
+يمكن حفظه، رهن بدين مؤجل، يحل، يحل
+
+82
+00:06:49,700 --> 00:06:55,340
+هذا الدين قبل الفساد طبعا، هنا في ثلاث حالات، خلينا في
+
+83
+00:06:55,340 --> 00:06:59,400
+الحالة الأولى، حاجة حاجة، نأخذ: إذا رهن ما يسرع
+
+84
+00:06:59,400 --> 00:07:00,320
+إليه الفساد،
+
+85
+00:07:03,040 --> 00:07:09,760
+بدين مؤجل، لكن يحل قبل الفساد، أيضا هنا نقول إن
+
+86
+00:07:09,760 --> 00:07:13,700
+الرهن يصح، يعني نفس الحكم هنا وهنا، تمام؟
+
+87
+00:07:13,700 --> 00:07:18,580
+إن الرهن يصح، خليني معي، دائما بالمثال يتضح المقال،
+
+88
+00:07:18,580 --> 00:07:24,700
+الآن بنقول: أنا بتاريخ اليوم اتدينت شغلة، وقلت له:
+
+89
+00:07:24,700 --> 00:07:30,560
+راح أدفع لك حقه بـ30/5،
+
+90
+00:07:30,560 --> 00:07:35,630
+تمام؟ فقال لي: ما في مشكلة، تفضلي، هي المبلغ، بس بدي
+
+91
+00:07:35,630 --> 00:07:39,710
+رهن، قلت له: بدي أرهن عندك البندورة، البندورة بالعادة
+
+92
+00:07:39,710 --> 00:07:44,730
+بدنا نفترض برضه مثال افتراضي، أنها بتفسد بـ5، 6
+
+93
+00:07:44,730 --> 00:07:51,730
+أيام، هذا إيش موقع الفساد؟ تمام؟ وهذا إيش أجل؟ الدين،
+
+94
+00:07:51,730 --> 00:07:57,710
+أجل الدين، حلو؟ فالآن قال لك: روح، هنا كالبندورة، اللي
+
+95
+00:07:57,710 --> 00:08:04,230
+هو ما يسرع للفساد، روح، هنا بدين مؤجل يحل قبل
+
+96
+00:08:04,230 --> 00:08:08,980
+الفساد، ها الفساد، هنا بتفسد البندورة هنا، لكن الدين
+
+97
+00:08:08,980 --> 00:08:13,580
+أجله جاء قبل فسادها، يعني المرتهن بيقدر يستفيد من
+
+98
+00:08:13,580 --> 00:08:17,100
+حقه أم لا؟ اه، بيقدر يستوفي حقه أم لا؟ اه، بيقدر،
+
+99
+00:08:17,100 --> 00:08:22,200
+إذا يصح الرهن وما في أي مشكلة، لأنه لن يحصل أي ضرر
+
+100
+00:08:22,200 --> 00:08:25,800
+على المرتهن، ممكن تقول لي: ما هي في 5، 6 هتفسد،
+
+101
+00:08:25,800 --> 00:08:28,780
+بقول لك: اه يا عم، ما إنت بيحج لك في 30/5، تبيع
+
+102
+00:08:28,780 --> 00:08:31,920
+لو ما دفع لي الفلوس، وفي 30/5 هي سليمة،
+
+103
+00:08:31,920 --> 00:08:36,900
+مية بالمية، فما عليك أي ضرر، علم؟ تمام، هذا إذا
+
+104
+00:08:36,900 --> 00:08:46,120
+رهنت بدين مؤجل، لكنه يحل وقته قبل فساد المرهون، علم؟
+
+105
+00:08:46,120 --> 00:08:52,710
+بينما لو رهن ما يسرع إليه الفساد، البندورة، اللي
+
+106
+00:08:52,710 --> 00:09:00,590
+ما فيش مجال لحفظها، بدين مؤجل، لكن هذا الدين يحل بعد
+
+107
+00:09:00,590 --> 00:09:07,510
+الفساد، هنا نفرق بين ثلاث أمور، لأن في لسه حالة
+
+108
+00:09:07,510 --> 00:09:15,970
+ثالثة، وحانقول ثلاث حالات، تمام؟ إذا روح هنا، المرهون
+
+109
+00:09:15,970 --> 00:09:24,070
+بدين مؤجل يحل بعد فساده، أي بعد فساد المرهون، هنا
+
+110
+00:09:24,070 --> 00:09:29,350
+نفرق، بينما إذا اشترط عليه البيع، أو اشترط عليه عدم
+
+111
+00:09:29,350 --> 00:09:33,790
+البيع، أو لم يشترط شيء، ثلاث حالات، وكل حالة لها حكمها
+
+112
+00:09:33,790 --> 00:09:39,010
+الخاص بها، نشوف: إذا، إذا رهن بدين مؤجل يحل بعد
+
+113
+00:09:39,010 --> 00:09:41,250
+الفساد، واشترط عليه
+
+114
+00:09:44,330 --> 00:09:51,670
+البيع، أو اشترط عليه عدم
+
+115
+00:09:51,670 --> 00:10:04,370
+البيع، أو لم يشترط عليه شيئا، خليكم
+
+116
+00:10:04,370 --> 00:10:09,410
+معي، الآن نرجع نحط تواريخ جديدة، ونفهم المسألة
+
+117
+00:10:09,410 --> 00:10:10,630
+أكثر،
+
+118
+00:10:13,910 --> 00:10:19,310
+نعم، إيش فيه؟ خوفتني يا ماما؟ طيب، مش أنا  حاضرة
+
+119
+00:10:19,310 --> 00:10:25,310
+أسفة، بتوقف، I'm sorry، إذا روحنا بدين مؤجل وهذا
+
+120
+00:10:25,310 --> 00:10:33,310
+الدين يحل بعد الفساد، لكن ركزوا معي، كان التاريخ،
+
+121
+00:10:33,310 --> 00:10:36,910
+... هتكتبوا التاريخ هنا، تمام؟ عشان أنا صرت بخاف منكم،
+
+122
+00:10:36,910 --> 00:10:40,090
+هتكتبوا التاريخ هنا، فالآن،
+
+123
+00:10:42,950 --> 00:10:46,310
+هذا الكلام ما له علاقة لا بهادا ولا بهادا، فاهمين؟ اه؟
+
+124
+00:10:46,310 --> 00:10:54,090
+أنا اتدينت شغلة، وقلت له: راح أدفع لك حقه، أو عفواً،
+
+125
+00:10:54,090 --> 00:11:01,970
+راح أدفع لك الدين اللي علي بـ10/6، بـ10/6،
+
+126
+00:11:01,970 --> 00:11:06,550
+تمام؟ يا حلّ،
+
+127
+00:11:09,560 --> 00:11:15,420
+الدين بيحل إيش؟ في 10/6، وقال لي: طب بدي رهن،
+
+128
+00:11:15,420 --> 00:11:18,260
+قلت له: بدي أرهن لكِ البندورة هذه، هاي، حمام البندورة،
+
+129
+00:11:18,260 --> 00:11:22,620
+كلها مرهونة لكِ، طب البندورة بتفسد أصلا بـ30/5،
+
+130
+00:11:22,620 --> 00:11:30,770
+هذا إيش أجل الفساد؟ تمام؟ وهذا إيش أجل؟ الدين،
+
+131
+00:11:30,770 --> 00:11:36,030
+إذا الدين يحل بعد الفساد، يعني الفساد قبل الدين، صح،
+
+132
+00:11:36,030 --> 00:11:40,230
+أم لا؟ الدين بعد الفساد، يعني أنا لو بدي أستوفي
+
+133
+00:11:40,230 --> 00:11:44,010
+موقع الدين، هيجي موقع الدين، مش هلاقي حاجة آخذ منها،
+
+134
+00:11:44,010 --> 00:11:48,810
+حاجة، صح ولا لأ؟ هذه هي، فالآن مفرق بين ثلاث شغلات، إن
+
+135
+00:11:48,810 --> 00:11:52,430
+الراهن أصلا ما هو عارف إن البندورة هتخرب، جاء بـ
+
+136
+00:11:52,430 --> 00:11:57,440
+الـ10/6، هو عارف، عارف إنها هتخرب، فإيش قال؟ قال
+
+137
+00:11:57,440 --> 00:12:03,900
+لي: بشرط أنك تبيع البندورة قبل ما تتلف، إذا حسيتها
+
+138
+00:12:03,900 --> 00:12:10,060
+بدها تخرب، بدها تتلف، بيعها، وخلي ثمنها هو المرهون،
+
+139
+00:12:10,060 --> 00:12:17,260
+بدلا منها، في هذه الحالة، نقول: يصح الرهن ويجب البيع،
+
+140
+00:12:17,260 --> 00:12:25,610
+طبيعي، يصح الرهن ويجب البيع، لازم تبيع، لأن لو
+
+141
+00:12:25,610 --> 00:12:28,910
+ما بيعش، أنت ضريت الطرفين، أنت ضريت حالك ابتداءً،
+
+142
+00:12:28,910 --> 00:12:33,670
+كمُرتهن، لأنه مش هيضل لك شيء تستوفي منه حقه، وضريت
+
+143
+00:12:33,670 --> 00:12:37,210
+البائع، لأن البائع حاطط في باله يسدك بـ10/6، و
+
+144
+00:12:37,210 --> 00:12:41,970
+ترجع له البندورة، أو يرجع له حقه، صح ولا لأ؟ فأنت هيك
+
+145
+00:12:41,970 --> 00:12:46,150
+ضيعت عليه مصالحه كمان، يعني أنت أضريت به ومن حاجة،
+
+146
+00:12:46,150 --> 00:12:50,370
+يرفع عليك دعوى، عشان كده قلنا: يجب عليك البيع، و
+
+147
+00:12:50,370 --> 00:12:54,790
+لما بنقول يجب، إنه أنت ستُحاسب لو ما بعتها، لأن أنت
+
+148
+00:12:54,790 --> 00:12:58,810
+مش بس أُنزلت عن حقك، أنت ضريت به أنا، لأن البندورة
+
+149
+00:12:58,810 --> 00:13:02,430
+هذه أصلا غالية، وبعدها كمان أسبوع، أسبوعين بالسوق،
+
+150
+00:13:02,430 --> 00:13:07,370
+هتصير الكيلو بعشرة شكل، وبالتالي حرمت عليك، يا زلمة،
+
+151
+00:13:07,370 --> 00:13:14,020
+أنت ضيعتني هيك، وصلت؟ طيب، حلو، زلمة بتصير راجل، راجل،
+
+152
+00:13:14,020 --> 00:13:19,080
+يا راجل، طيب، حلو؟ عشان في ناس استحجنت من الكلمة،
+
+153
+00:13:19,080 --> 00:13:24,840
+وإنها كلمة عادية، يعني طيب okay، تمام، طيب، يا شماعة،
+
+154
+00:13:24,840 --> 00:13:31,420
+نرجع نقول، لا، صلوا على رسول الله، إذا،
+
+155
+00:13:31,420 --> 00:13:37,500
+اشترط عليه البيع، الرهن صحيح، والبيع واجب، طيب، رهن ما
+
+156
+00:13:37,500 --> 00:13:42,520
+يسرع إليه الفساد، وكان مما لا يمكن حفظه، بدين مؤجل،
+
+157
+00:13:42,520 --> 00:13:47,800
+يحل بعد الفساد، واشترط عليه عدم البيع، يعني نفس،
+
+158
+00:13:47,800 --> 00:13:52,060
+الشيء، قال له: أسدك الدين بـ10/6، وقال له: طب بدي
+
+159
+00:13:52,060 --> 00:13:55,140
+رهن، رهن بندورة، البندورة بتفسد في 30/5، هذه
+
+160
+00:13:55,140 --> 00:13:58,140
+كلها أمثلة افتراضية، وتواريخ افتراضية، 30/5
+
+161
+00:13:58,140 --> 00:14:03,970
+بتفسد، okay، جاء له، بس بشرط: اوعك تبيعها، جاء الـ10/6،
+
+162
+00:14:03,970 --> 00:14:08,750
+اوعك ت
+
+223
+00:19:48,000 --> 00:19:54,100
+بالعادة لما أنت بتدين شيئًا و بترهن شيئًا مقابله
+
+224
+00:19:54,100 --> 00:19:58,220
+يغلب على ظنك عدم فساده، يعني أنت بترهن شغلة و حاطط
+
+225
+00:19:58,220 --> 00:20:02,200
+في بالك أنها هتصمد للتاريخ، مش هتفسد، مش هتتلف، هيك
+
+226
+00:20:02,200 --> 00:20:05,920
+الأصل هيك، الغالب، وبناء على ذلك سيبقى الشيء المرهون
+
+227
+00:20:05,920 --> 00:20:09,480
+يستوفي منه حقه، وبالتالي ما في مشكلة بالرهن هذا
+
+228
+00:20:09,480 --> 00:20:15,300
+الرأي الأول، وهو الأظهر، أما الرأي الثاني، قلنا كلامكم
+
+229
+00:20:15,300 --> 00:20:19,220
+على رأسي يا أصحاب الرأي الأول، okay، الغالب إنه
+
+230
+00:20:19,220 --> 00:20:23,400
+ما فيش فساد، لكن إمكانية الفساد قائمة، احتمال
+
+231
+00:20:23,400 --> 00:20:28,100
+الفساد قائم، وكونوا فيه احتمال لإنه يفسد، إذًا لن
+
+232
+00:20:28,100 --> 00:20:32,710
+يبقى شيء للمرتهن يستوفي منه حقه، من هنا بنقول
+
+233
+00:20:32,710 --> 00:20:37,450
+ببطلان الرهن، ببطلان الرهن، لكن الأظهر هو الأول، أن
+
+234
+00:20:37,450 --> 00:20:43,490
+الرهن يصح لأن عادة في شريعتنا الغراء العبرة دائمًا
+
+235
+00:20:43,490 --> 00:20:47,570
+بالكثير الغالب، لا بالقليل النادر، دائمًا العبرة
+
+236
+00:20:47,570 --> 00:20:53,630
+بالكثير الغالب، لا بالقليل النادر، علم واضح في أي
+
+237
+00:20:53,630 --> 00:20:58,650
+استفسار، هذا بالنسبة لموضوع
+
+238
+00:21:00,540 --> 00:21:07,100
+رهن ما يسرع إليه الفساد، فتحدثنا عن كل الحالات
+
+239
+00:21:07,100 --> 00:21:12,940
+المتعلقة به، الآن سننتقل للحديث عن رهن ما لا يسرع
+
+240
+00:21:12,940 --> 00:21:18,320
+إليه الفساد، إذا طرأ عليه ما يسرعه، لكن قبل ما نتحدث
+
+241
+00:21:18,320 --> 00:21:22,680
+بدي أرجع أقول بأن قضية رهن ما يسرع إليه الفساد
+
+242
+00:21:23,800 --> 00:21:28,040
+دائمًا بدك تحللي، يعني أنا ممكن أجيب لك تاريخ فلان
+
+243
+00:21:28,040 --> 00:21:32,460
+دائن له تاريخ كذا، ورهن، والشيء ممكن يفسد بتاريخ كذا،
+
+244
+00:21:32,460 --> 00:21:35,800
+فأنت بدك تكون فاهمة الفكرة، وعلى طول بتحللي، يعني
+
+245
+00:21:35,800 --> 00:21:40,860
+مش حفظ، هتكون يعني مسألة سهلة، لكن تحفظيش ولا حاجة،
+
+246
+00:21:40,860 --> 00:21:44,520
+هذا اللي بدي أقوله لك، لأن الموضوع أنا متأكدة بعد
+
+247
+00:21:44,520 --> 00:21:49,290
+شرحي، ما فيه أي إشكالية مطلقًا، فأنت افهمي دائمًا عشان
+
+248
+00:21:49,290 --> 00:21:52,930
+تتمكني من الإجابة على أي سؤال يوجه إليك في هذا
+
+249
+00:21:52,930 --> 00:21:58,930
+الموضوع، نتحدث الآن عن رهن ما لا يسرع إليه الفساد
+
+250
+00:21:58,930 --> 00:22:01,850
+إذا طرأ عليه ما يفسده
+
+251
+00:22:12,310 --> 00:22:16,830
+هذه المسألة قصيرة، مش زي السابقة، يعني هيكون فيها
+
+252
+00:22:16,830 --> 00:22:27,350
+كلام مقتضب إن شاء الله، إذا راح مال ما لا يسرع
+
+253
+00:22:27,350 --> 00:22:33,070
+إليه الفساد، إذا طرأ
+
+254
+00:22:36,800 --> 00:22:42,760
+عليه ما... ما يفسده، إيش ما لا يفسده؟ بيصير ما لوش
+
+255
+00:22:42,760 --> 00:22:48,700
+لازمة أصلًا، تمام، إذا بدي أفترض جدلًا قبل ما نفصل
+
+256
+00:22:48,700 --> 00:22:53,760
+كحكم، إنه أنا روحت لدائن، مبلغ من المال، طلب مني رهن،
+
+257
+00:22:53,760 --> 00:22:59,340
+رهنت عنده مثلًا ثلاثة أطنان، هي طن ولا أطنان؟ شو رأيكم؟
+
+258
+00:23:00,440 --> 00:23:06,180
+أطنان، إذا رهنت عنده ثلاثة أطنان من القمح، آه، كلغة
+
+259
+00:23:06,180 --> 00:23:09,940
+بيكسر الطائي وليس بيضمها، في كلام كتير بنحكي غلط،
+
+260
+00:23:09,940 --> 00:23:18,980
+إحنا طيب، إذا ثلاثة أطنان من القمح مقابل الدين اللي
+
+261
+00:23:18,980 --> 00:23:23,160
+أنا اقترضته، حلو؟ وكنا بنعرف القمح لا يسرع
+
+262
+00:23:23,160 --> 00:23:28,380
+الفساد، بيقعد سنوات، بصمد ما شاء الله، تمام؟ حلو هذا
+
+263
+00:23:28,380 --> 00:23:33,760
+القمح اللي في الأصل لا يسرع إليه الفساد، طرأ عليه ما
+
+264
+00:23:33,760 --> 00:23:38,440
+يفسده، أصابته رطوبة، وإذا صار فيه رطوبة مش هيصمد
+
+265
+00:23:38,440 --> 00:23:42,690
+كتير، لازم على طول تروح تطحنه، إلا خلاص راح عليك، صح
+
+266
+00:23:42,690 --> 00:23:47,810
+ولا لأ؟ حلو، أنا رهنت القمح، رهنته، إني بدي أرهنك
+
+267
+00:23:47,810 --> 00:23:51,650
+القمح، جالي قبلت، يعني صار في صيغة بيني وبينك، تمام
+
+268
+00:23:51,650 --> 00:23:55,750
+تمام، يعني تم عقد الرهن بيننا، ولما تم الرهن ممكن
+
+269
+00:23:55,750 --> 00:24:00,130
+أكون سلمتك الرهن، وممكن لسه ما سلمتك، صح ولا لأ؟
+
+270
+00:24:00,130 --> 00:24:04,930
+ممكن سلمتك، وممكن لسه ما سلمتك، فلذلك بدنا نفرق
+
+271
+00:24:04,930 --> 00:24:11,680
+بين ما إذا تم القبض أو لم يتم القبض، إذا طرأ الفساد
+
+272
+00:24:11,680 --> 00:24:17,360
+بعد القبض أو قبل القبض، صرنا فاهمين شو يعني قبل و
+
+273
+00:24:17,360 --> 00:24:23,620
+بعد؟ تمام، فإذا الفساد طرأ على المرهون بعد قبضه،
+
+274
+00:24:23,620 --> 00:24:28,400
+يعني المرتهن استلم القمح، وأصابته رطوبة، طبعًا
+
+275
+00:24:28,400 --> 00:24:32,940
+بدون تقصير من المرتهن، في هذه الحالة بنقول قولًا
+
+276
+00:24:32,940 --> 00:24:34,780
+واحدًا، لا ينفسخ
+
+277
+00:24:37,830 --> 00:24:42,050
+عقد الرهن، بمعنى يبقى الرهن قائم بين الراهن
+
+278
+00:24:42,050 --> 00:24:45,290
+والمرتهن، طب إيش الحل؟ القمح هيُطلف لو  دلوقت زي كده
+
+279
+00:24:45,290 --> 00:24:52,010
+يعني قال لك لا ينفسخ، ويجب على الراهن... مين
+
+280
+00:24:52,010 --> 00:24:58,070
+الراهن؟ صاحب القمح، ويجب على الراهن بيعه، وجعل
+
+281
+00:24:58,070 --> 00:25:05,220
+ثمنه مرهونًا بدلًا منهم، لازم الراهن ياخد القمح، و
+
+282
+00:25:05,220 --> 00:25:09,800
+يديهم مثلًا على المطحنة يبيعهم، وياخد ثمنهم،
+
+283
+00:25:09,800 --> 00:25:17,270
+ويرهنه مقابل إيش؟ الدين اللي، أو يرهن ال... يجعل
+
+284
+00:25:17,270 --> 00:25:22,430
+عفوًا، الثمن كأنه قمح، يعني مرهون بدل القمح، تمام؟
+
+285
+00:25:22,430 --> 00:25:27,330
+واضح؟ حلو، وهذا ما فيه خلاف، إذا تم القبض، لكن إذا
+
+286
+00:25:27,330 --> 00:25:32,230
+المرتهن لسه ما تم قبض القمح، القمح لسه عند مين؟ عند
+
+287
+00:25:32,230 --> 00:25:38,910
+الراهن، وأصابته مثلًا رطوبة، يعني طرأ عليه ما يفسده،
+
+288
+00:25:38,910 --> 00:25:42,350
+في هذه الحالة، هل ينفسخ الرهن أو لا؟ قولين؟
+
+289
+00:25:46,520 --> 00:25:53,060
+الأصح إيش؟ أنه لا ينفسخ، ولما بنقول لا ينفسخ نفس
+
+290
+00:25:53,060 --> 00:25:56,720
+الشيء إنه إيش؟ يجب على الراهن بيعه، وجعل ثمنه
+
+291
+00:25:56,720 --> 00:26:00,560
+مرهونًا بدلًا منه، نفس الحكم هنا وهنا، لكن الفرق إن
+
+292
+00:26:00,560 --> 00:26:05,000
+هنا ما في خلاف، هنا على الأصح، وبالتالي لما بقول على
+
+293
+00:26:05,000 --> 00:26:10,120
+الأصح، معناته في رأي ثاني بيقول إن الرهن ينفسخ،
+
+294
+00:26:10,810 --> 00:26:16,950
+ولما بنقول الرهن ينفسخ، يعني وجب على الراهن أن
+
+295
+00:26:16,950 --> 00:26:22,690
+يأتي برهن جديد، يأتي برهن جديد، لأنه ما عاد فيه رهن،
+
+296
+00:26:22,690 --> 00:26:26,990
+لدائن، ما عاد فيه رهن، هو دين، و بده رهن، والرهن
+
+297
+00:26:26,990 --> 00:26:31,970
+خلاص ما عاد قائم، فلازم أرهن حاجة جديدة، نرجع واضح هذا
+
+298
+00:26:31,970 --> 00:26:36,130
+ما يتعلق بموضوع محاضرتنا لهذا اليوم، المحاضرة
+
+299
+00:26:36,130 --> 00:26:42,410
+القادمة بإذن الله سنتحدث عن موضوع جديد أيضًا يتعلق
+
+300
+00:26:42,410 --> 00:26:48,430
+بالمرهون، ألا وهو استعارة الشيء من أجل رهنه، تمام؟
+
+301
+00:26:48,430 --> 00:26:52,370
+أقول قولي هذا وأستغفر الله لي ولكم، وصلى الله وسلم
+
+302
+00:26:52,370 --> 00:26:56,410
+وبارك على سيدنا محمد، والسلام عليكم ورحمة الله
+
+303
+00:26:56,410 --> 00:26:57,790
+وتعالى وبركاته
diff --git a/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/jf6tkT1DrxI_raw.json b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/jf6tkT1DrxI_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..b5dcdf775ed473733b58e8be1a60da2399d9ad81
--- /dev/null
+++ b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/jf6tkT1DrxI_raw.json
@@ -0,0 +1 @@
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"text": "وقت ما اشتريته وقت العقد في منه فايدة في منه منفع لأ لكن مقالا مستقبلا إله منفع فما في أي مشكلة", "tokens": [30543, 2655, 19446, 1975, 8592, 2655, 16572, 47395, 4032, 38149, 18863, 28543, 8978, 9154, 3224, 6156, 995, 25708, 3660, 8978, 9154, 3224, 9154, 5172, 3615, 5296, 10721, 44381, 3714, 4587, 6027, 995, 3714, 14851, 4587, 3555, 15040, 11933, 43761, 9154, 5172, 3615, 6156, 15042, 8978, 36632, 37893, 28820, 3660], "avg_logprob": -0.19203124970197677, "compression_ratio": 1.5596330275229358, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1242.45, "end": 1242.91, "word": "وقت", "probability": 0.968505859375}, {"start": 1242.91, "end": 1243.05, "word": " ما", "probability": 0.5}, {"start": 1243.05, "end": 1243.63, "word": " اشتريته", "probability": 0.86064453125}, {"start": 1243.63, "end": 1243.91, "word": " وقت", "probability": 0.86279296875}, {"start": 1243.91, "end": 1244.49, "word": " العقد", "probability": 0.932861328125}, {"start": 1244.49, "end": 1245.01, 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2431.47, "end": 2431.85, "word": " بإذن", "probability": 0.9500732421875}, {"start": 2431.85, "end": 2432.41, "word": " الله،", "probability": 0.823486328125}, {"start": 2432.41, "end": 2432.59, "word": " إلى", "probability": 0.90771484375}, {"start": 2432.59, "end": 2432.83, "word": " هنا", "probability": 0.962890625}, {"start": 2432.83, "end": 2433.15, "word": " نكون", "probability": 0.961669921875}, {"start": 2433.15, "end": 2433.39, "word": " قد", "probability": 0.7958984375}, {"start": 2433.39, "end": 2433.81, "word": " انتهينا", "probability": 0.9342041015625}, {"start": 2433.81, "end": 2433.95, "word": " من", "probability": 0.9814453125}, {"start": 2433.95, "end": 2434.29, "word": " موضوع", "probability": 0.9970703125}, {"start": 2434.29, "end": 2435.43, "word": " محاضرتنا،", "probability": 0.8917643229166666}, {"start": 2435.43, "end": 2435.73, "word": " أقول", "probability": 0.887451171875}, {"start": 2435.73, "end": 2436.09, "word": " قولي", "probability": 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/m1iRCgNfyac.srt b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/m1iRCgNfyac.srt
new file mode 100644
index 0000000000000000000000000000000000000000..949826909b30df5587259fb341c4d3bae9460a10
--- /dev/null
+++ b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/m1iRCgNfyac.srt
@@ -0,0 +1,1073 @@
+1
+00:00:05,160 --> 00:00:07,880
+أعوذ بالله من الشيطان الرجيم، بسم
+
+2
+00:00:07,880 --> 00:00:11,020
+الله الرحمن الرحيم، الحمد لله رب العالمين، والصلاة
+
+3
+00:00:11,020 --> 00:00:15,080
+والسلام على أشرف الأنبياء والمرسلين، سيدنا محمد بن
+
+4
+00:00:15,080 --> 00:00:18,480
+عبد الله الصادق الأمين، ثم أما بعد، أحيكم جميعا بتحية
+
+5
+00:00:18,480 --> 00:00:23,080
+الإسلام، السلام عليكم ورحمة الله تعالى وبركاته، كيف
+
+6
+00:00:23,080 --> 00:00:27,180
+حالكم؟ طيبات إن شاء الله؟ عظيم، حضوركم جيد إن شاء
+
+7
+00:00:27,180 --> 00:00:32,960
+الله، طيب، برضه عظيم، إذا المحاضرة السابقة كنا قد
+
+8
+00:00:32,960 --> 00:00:38,000
+تحدثنا حول رهن ما يسرع إليه الفساد، وكذا رهن ما لا
+
+9
+00:00:38,000 --> 00:00:42,060
+يسرع إليه الفساد إذا طرأ عليه ما يفسده، ولِسنا
+
+10
+00:00:42,060 --> 00:00:47,620
+بحاجة لأن نكرر ما تحدثنا عنه سابقا، لأن أظن المسألة
+
+11
+00:00:47,620 --> 00:00:52,410
+باتت واضحة، اليوم بإذن الله سنتحدث عن مسألة جديدة
+
+12
+00:00:52,410 --> 00:00:57,150
+تتعلق أيضا بالمرهون، ألا وهو استعارة الشيء من أجل
+
+13
+00:00:57,150 --> 00:01:01,810
+رهنه، كنا قد تحدثنا سابقا أن الأصل أن الإنسان
+
+14
+00:01:01,810 --> 00:01:07,170
+يرهن شيئا يملكه، شيئا له، شيئا خاصا به، مقابل الدين
+
+15
+00:01:07,170 --> 00:01:12,630
+الذي يقترضه، ومع ذلك السؤال الذي يطرح نفسه هنا: هل
+
+16
+00:01:12,630 --> 00:01:20,520
+يجوز للشخص أن يستعير ليُرهن؟ نقول: نعم، لكن الإجابة
+
+17
+00:01:20,520 --> 00:01:25,580
+الصحيحة، إنه ما فيها خلاف، إنه ينفع، لكن السؤال الثاني
+
+18
+00:01:25,580 --> 00:01:29,980
+الذي يطرح نفسه: طيب، أنا لما أستعير لأجل الرهن، هل
+
+19
+00:01:29,980 --> 00:01:35,600
+يبقى هذا الشيء الذي استعاره المستعير فيه حقه عاريا،
+
+20
+00:01:35,600 --> 00:01:40,140
+أم ينقلب إلى ضمان لدين؟ كان هناك خلاف بين
+
+21
+00:01:40,140 --> 00:01:45,000
+الشافعية في هذه المسألة، وقبل عرض الخلاف، لابد أن نفهم
+
+22
+00:01:45,000 --> 00:01:49,780
+صورة المسألة، وبعدها نتحدث عن الخلاف فيها، فلحظة، أنا
+
+23
+00:01:49,780 --> 00:01:54,320
+أقول: استعارة شيء من أجل رهنه، فكأنه صار عندي ثلاث
+
+24
+00:01:54,320 --> 00:01:58,340
+عقود، يا جماعة، عندي دين، وعندي عارية، وعندي رهن، حلو؟
+
+25
+00:01:58,340 --> 00:02:03,580
+عندي ثلاث عقود، مش عقدين، حلو؟ نشوف الآن العقد الأول
+
+26
+00:02:03,580 --> 00:02:11,430
+كان فيه دين بين محمد وأحمد، حلو؟ محمد هذا هو
+
+27
+00:02:11,430 --> 00:02:16,530
+الدائن، هذا عقد الدائن الأول، الأساسي، اللي بينهم
+
+28
+00:02:16,530 --> 00:02:22,760
+عليه كذا وكذا، وأحمد هو ماذا؟ المدين، فأحمد
+
+29
+00:02:22,760 --> 00:02:29,480
+قال لمحمد: بدي خمسة آلاف دولار، خمسة آلاف دولار عنده
+
+30
+00:02:29,480 --> 00:02:34,820
+مشروع معين بدي أقم به، وأساسا هو موعود بفلوس
+
+31
+00:02:34,820 --> 00:02:38,940
+تجيه إليه، حواله فيه ميراث بده يتجسم، هيأخذ حصته،
+
+32
+00:02:38,940 --> 00:02:44,040
+والمهم، بناء على ذلك، محمد قال له: ماعندي مشكلة، بس
+
+33
+00:02:44,040 --> 00:02:50,580
+بدي رهن، أتأكد أنه الخمسة آلاف دولار ترجع إليه، فأحمد
+
+34
+00:02:50,580 --> 00:02:57,220
+ماعنده حاجة يرهنها، حلو، فراح لمين؟ لَحمدية، هي السيدة
+
+35
+00:02:57,220 --> 00:03:05,630
+راح للسيدة، أخد معاه كأس قهوة كابتشينو، عمل لها إياها،
+
+36
+00:03:05,630 --> 00:03:12,710
+هو بيده، أخذ وردة، شوكولاتة، وراح للسيدة، قال لها: يا
+
+37
+00:03:12,710 --> 00:03:16,350
+بنت الناس، أنتِ عارفة ال… الوضع المالي اللي أنا فيه،
+
+38
+00:03:16,350 --> 00:03:21,430
+في غزة، وبصراحة، وأنا بدي أعمل لي مشروع، فربنا يوفقنا
+
+39
+00:03:21,430 --> 00:03:26,490
+فيه، ويسر لنا أمورنا، فبدي تيجي في جنبي، بدي أستعير
+
+40
+00:03:26,490 --> 00:03:35,700
+دهباتك، يا بنت الناس، إعارة، هترجع لك، أنا متدين خمسة
+
+41
+00:03:35,700 --> 00:03:39,100
+آلاف دولار من محمد فلان فلان اللي أنتِ بتعرفيه،
+
+42
+00:03:39,100 --> 00:03:45,160
+متدين من محمد خمسة آلاف دولار، وقلت له: بدي أسدّ لك إياهم
+
+43
+00:03:45,160 --> 00:03:51,760
+في واحد وتسعة، دهباتك هترجع لك بواحد وتسعة، دهباتك
+
+44
+00:03:51,760 --> 00:03:55,580
+هترجع لك بواحد وتسعة، فالله يرضى عليكي، ساعيني،
+
+45
+00:03:55,580 --> 00:03:59,180
+طبعا هي شافت الوردة، وهذا بدها تقول: لا، لو… لو يا
+
+46
+00:03:59,180 --> 00:04:03,480
+بن عمّ، تفضلي، ها، وأعطته الدهبات، الآن استعار
+
+47
+00:04:03,480 --> 00:04:09,260
+الدهب، ها، استعاره لِشُو؟ ليرهنّه، ليرهنّه، حلو؟ تمام.
+
+48
+00:04:09,710 --> 00:04:15,870
+فالآن في عندنا عقد جديد، اللي هو عقد عارية، أو إعارة،
+
+49
+00:04:15,870 --> 00:04:19,510
+طبعا الإعارة، والإعارة، وفي من العلماء، العلماء
+
+50
+00:04:19,510 --> 00:04:24,830
+في اللغة، يقولون عنها عارة، سواء قلنا عارية، أو إعارة،
+
+51
+00:04:24,830 --> 00:04:28,850
+أو استعارة، أو عارية بالتخفيف، أو عارة، كلها نفس
+
+52
+00:04:28,850 --> 00:04:35,140
+الشيء، الآن العارية هذه اللي بين حمدية وأحمد، من
+
+53
+00:04:35,140 --> 00:04:39,480
+المُعيرة، ومن المُستعير، هذا المُستعير، تمام؟ وهذه هي
+
+54
+00:04:39,480 --> 00:04:46,940
+المُعيرة، حلو؟ تمام؟ فالآن أحمد كمدين، كمُستعير، هيصير
+
+55
+00:04:46,940 --> 00:04:51,500
+راهنًا بالمرهون، لأنه استعار لِشو؟ لِشو؟ ليرهن، فهذا
+
+56
+00:04:51,500 --> 00:04:59,560
+هو الراهن صار، وهذا المَرتهن، حلو؟ فإذا الآن ما في
+
+57
+00:04:59,560 --> 00:05:03,540
+خلاف بين العلماء أنه يجوز الاستعارة حتى أرهن، هذا
+
+58
+00:05:03,540 --> 00:05:08,560
+خلاص، مفروغ منه، الخلاف بينهم في أنه أنا كأحمد، لما
+
+59
+00:05:08,560 --> 00:05:12,840
+استعرت،  أنا استعرت،  مش لأجل الإعارة،
+
+60
+00:05:12,840 --> 00:05:17,940
+أنا استعرت حتى أرهن، هل، يا ترى، استعارتي لأجل الرهن
+
+61
+00:05:17,940 --> 00:05:26,100
+يبقى العقد اللي كان بيني وبين حمدية يبقى عارية، أم
+
+62
+00:05:26,100 --> 00:05:30,640
+ينقلب إلى ضمان للدين؟ خلاف بين فقهاء الشافعية على
+
+63
+00:05:30,640 --> 00:05:36,000
+قولين، إنه طبعا الإعارة كإعارة، بتظل إعارة، وما في مجال
+
+64
+00:05:36,000 --> 00:05:39,860
+تتحول، لكن أنا هنا لا أتحدث عن الإعارة إن أنا
+
+65
+00:05:39,860 --> 00:05:43,920
+استعرت لأجل الإعارة، أنا استعرت لأجل الرهن، كوني
+
+66
+00:05:43,920 --> 00:05:48,660
+استعرت لأجل الرهن، هل يبقى العقد عقد عارية، يبقى عارية،
+
+67
+00:05:48,660 --> 00:05:54,680
+أم ينقلب إلى ضمان للدين؟ خلاف على قولين، الأظهر عند
+
+68
+00:05:54,680 --> 00:06:00,240
+علماء الشافعية، قالوا إن الإعارة من أجل الرهن
+
+69
+00:06:00,240 --> 00:06:07,060
+تنقلب إلى ضمان للدين، بينما الرأي الثاني قال: تبقى
+
+70
+00:06:07,060 --> 00:06:12,120
+عارية، تبقى عارية، وطبعا لما نقول تنقلب إلى ضمان، أو
+
+71
+00:06:12,120 --> 00:06:15,360
+تبقى عارية، كل واحدة لها أحكامها الخاصة بها،
+
+72
+00:06:15,360 --> 00:06:21,820
+وبالتالي، بناء على القول الأول القائل إن العارية من
+
+73
+00:06:21,820 --> 00:06:28,720
+أجل الرهن تنقلب إلى ضمان للدين، يجب على المستعير أن
+
+74
+00:06:28,720 --> 00:06:33,800
+يُخبر المُعير، يجب على المستعير أن يُخبر المُعير بأربعة
+
+75
+00:06:33,800 --> 00:06:39,530
+شغلات، واجب، هذا إذا قلنا إن العارية من أجل الرهن تنقلب
+
+76
+00:06:39,530 --> 00:06:44,730
+إلى ضمان للدين، فأصبح من الواجب على المستعير أن
+
+77
+00:06:44,730 --> 00:06:49,670
+يُخبر المُعير بأربعة شغلات، أول شيء بدي يقوله: جنس الدين،
+
+78
+00:06:49,670 --> 00:06:54,390
+لازم أحمد يكون صادق مع حمدية، أن هو الدين دينار، ولا
+
+79
+00:06:54,390 --> 00:06:58,190
+دولار، ولا شكل، ولا يورو، إِيضاح الجنس، لازم يكون حاكي
+
+80
+00:06:58,190 --> 00:07:03,150
+دينار، وبالتالي لو قال دينار، ممنوع يكون هو أصلا مدين
+
+81
+00:07:03,150 --> 00:07:08,370
+دولار، ويقول دينار، لازم يكون بالضبط، بعدين بدي يقول له
+
+82
+00:07:08,370 --> 00:07:14,570
+القدر، إنه خمسة آلاف، ولا ستة، ولا ثلاثة، ولا جُداش، لازم
+
+83
+00:07:14,570 --> 00:07:20,690
+بالضبط يقول له المقدار، يعني لو كان هو أصلا مدين
+
+84
+00:07:20,690 --> 00:07:27,030
+خمسة آلاف، ممنوع يقول لِحمدية أنا مدين أربعة آلاف،
+
+85
+00:07:27,030 --> 00:07:34,370
+ركزوا معايا، أفهموا، ممنوع يقول لِحمدية أنا مدين ستة
+
+86
+00:07:34,370 --> 00:07:42,170
+آلاف، لكن عادي… ركزوا… عادي يكون هو مدين أجل، و
+
+87
+00:07:42,170 --> 00:07:45,570
+حكا لها أكثر، لكن مش عادي يكون مدين أكثر وحكا لها
+
+88
+00:07:45,570 --> 00:07:50,030
+أقل، مرة ثانية، يعني هو مدين خمسة، مدين خمسة، في
+
+89
+00:07:50,030 --> 00:07:56,690
+الأصل مدين خمسة، وقال لها: أنا مدين مثلا أربعة
+
+90
+00:07:56,690 --> 00:08:02,830
+آلاف، ينفع؟ لأ، لأ، لأن هو الأصل خمسة مش أربعة، لكن لو
+
+91
+00:08:02,830 --> 00:08:06,330
+هو أصلا متدين أربعة، وقال لها خمسة، ينفع؟ اه، ينفع،
+
+92
+00:08:06,330 --> 00:08:12,710
+وصلت الفكرة؟ يعني ينفع، عادي جدا يكون الدهب مرهون
+
+93
+00:08:12,710 --> 00:08:17,710
+بشيء أقل من الدين الحقيقي، اه، لكن أكثر ما ينفعش،
+
+94
+00:08:17,710 --> 00:08:22,730
+وبالتالي، إذا هو متدين خمسة، لازم يقولها: أنا خمسة،
+
+95
+00:08:23,850 --> 00:08:27,690
+يقول لها ستة، مش مشكلة، لكن ممنوع يقول لها أربعة، وصلت الفكرة؟
+
+96
+00:08:27,690 --> 00:08:34,430
+لأنه منطقي، أساسا إذا كان قيمة الدين أكبر، معناته
+
+97
+00:08:34,430 --> 00:08:40,610
+هيصرف فكة دهب من اللي هتتدفع لِحمدية، فلازم يكون
+
+98
+00:08:40,610 --> 00:08:45,700
+صادق، طيب، كمان لازم يخبرها بالصفة، إنه أنا اتدينت
+
+99
+00:08:45,700 --> 00:08:51,840
+الفلوس اللي رهنت دهبي مقابلهم لمدة مثلا ثلاثة شهور،
+
+100
+00:08:51,840 --> 00:08:56,800
+مثلا، فممنوع يكون الدين أكثر من ثلاثة شهور، لكن عادي
+
+101
+00:08:56,800 --> 00:09:01,220
+يكون شهرين، وصلت؟ ممنوع يكون أكثر من ثلاثة شهور، إذا هو
+
+102
+00:09:01,220 --> 00:09:05,140
+قال لها ثلاثة، ممنوع يكون أكثر، لكن عادي يكون أقل، حلو.
+
+103
+00:09:05,140 --> 00:09:09,020
+الأمر الرابع، الأمر الرابع، بنقول: يجب، لكن على الأصح،
+
+104
+00:09:09,020 --> 00:09:12,120
+بمعنى: مش كل الشافعية متفقين على إنه لازم يقول
+
+105
+00:09:12,120 --> 00:09:15,340
+هالشغلة الرابعة، لحظة، الشغلة الأولى والثانية والثالثة
+
+106
+00:09:15,340 --> 00:09:18,980
+الثالثة، عند الكل لازم، إذا قلنا: ينقلب إلى ضمان،
+
+107
+00:09:18,980 --> 00:09:25,100
+للدين، لازم المستعير يخبر المُعير، الشغلة الرابعة، أصح
+
+108
+00:09:25,100 --> 00:09:30,300
+أنه لازم يخبر إيش هي؟ لازم المستعير يحكي للمُعير،
+
+109
+00:09:30,300 --> 00:09:36,440
+مين هو المرتهن، لأنه أنا كحمدية، بقبل يكونوا
+
+110
+00:09:36,440 --> 00:09:38,780
+عند فلان، بقبلش يكونوا عند فلان، أنا عارفة فلان
+
+111
+00:09:38,780 --> 00:09:46,020
+أصلا الحاجة اللي عنده بتصمدش، بيُخرب، بيحافظش،
+
+112
+00:09:46,020 --> 00:09:50,040
+الحاجات أصلا، بيُخربها، كيف حاجة تغيرها، وإلى غير
+
+113
+00:09:50,040 --> 00:09:54,000
+ذلك، ما بمنّيش حاجتي تكون عند فلان، لكن فلان الثاني،
+
+114
+00:09:54,000 --> 00:09:57,940
+لأ، أنا برتاح له، حاجتي هتضل زي ما هي عنده، مثلا، ها،
+
+115
+00:09:58,930 --> 00:10:02,890
+من هنا نقول: واجب على المستعير يقول: عند مين بدي
+
+116
+00:10:02,890 --> 00:10:06,730
+أحط الدهب؟ لأنه أنا ممكن أقبل دهبي يكون عند محمد،
+
+117
+00:10:06,730 --> 00:10:11,790
+بعرف محمد إنسان مُهندم، زوجته ما شاء الله كذا،
+
+118
+00:10:11,790 --> 00:10:15,410
+بيحافظوا على الأشياء، لكن في المقابل، في ناس بتعطيهم
+
+119
+00:10:15,410 --> 00:10:20,750
+الحاجة بيروحوا لها معاقة، صح ولا لا؟ فلذلك بدّه يكون
+
+120
+00:10:20,750 --> 00:10:26,130
+صادق في أني أنا عند مين حطيت هاي الشغلة، علم؟ حلو، و
+
+121
+00:10:26,130 --> 00:10:29,130
+هذا الكلام يا جماعة منطقي، لأنه أنا بدي أفرض جدلا،
+
+122
+00:10:29,130 --> 00:10:35,350
+أنا يعني مثلا حطيت عندك ال… خليني أقول مثلا أي
+
+123
+00:10:35,350 --> 00:10:40,170
+حاجة، أفرض يا ستي رهنت عندك شغل خاصة بيا أنا، شو
+
+124
+00:10:40,170 --> 00:10:44,530
+بدي أفرض… يا ستي جوال، ساعتك، طبعا الأصل أنك
+
+125
+00:10:44,530 --> 00:10:48,250
+تخليها يعني في حفظ، وفي الصندوق، وفي كده، أنت لما
+
+126
+00:10:48,250 --> 00:10:51,990
+تشوفي ابنك بيعيط وكده بتدي له إياها يلعب فيها، أنا
+
+127
+00:10:51,990 --> 00:10:56,890
+بدي أؤمنك على حاجتي، بالتأكيد لأ، صح ولا صح؟ أكيد صح،
+
+128
+00:10:56,890 --> 00:11:02,790
+وصلت الفكرة؟ اه، حلو، هذا إذا قلنا إن الإعارة من أجل
+
+129
+00:11:02,790 --> 00:11:05,930
+الرهن تنقلب إلى ضمان للدين، حينها يجب على المستعير
+
+130
+00:11:05,930 --> 00:11:10,090
+أن يُخبر المُعير بأربعة أمور ذكرناهم، بينما على القول
+
+131
+00:11:10,090 --> 00:11:16,770
+القائل إن العارية من أجل الرهن تبقى عارية، ولا تنقلب
+
+132
+00:11:16,770 --> 00:11:20,970
+إلى ضمان للدين، لا يجب على المستعير أن يُخبر المُعير
+
+133
+00:11:20,970 --> 00:11:24,950
+بشأن هذه الأمور الأربعة اللي ذكرناهم، مش واجب، لا
+
+134
+00:11:24,950 --> 00:11:29,230
+يحكي له كذا، لا جنس ولا قدر ولا صفة ولا من هو
+
+135
+00:11:29,230 --> 00:11:34,410
+المرتهن، لكن شغل أساسية لازم تكون حاضرة، وهي أنه لا
+
+136
+00:11:34,410 --> 00:11:39,930
+يجوز للمستعير أن يرهن الدهبات في المثال اللي ذكرنا،
+
+137
+00:11:39,930 --> 00:11:44,630
+أن يرهن الدهبات بأكثر من قيمتها، لازم يرهنها بِدين
+
+138
+00:11:44,630 --> 00:11:51,930
+مساوٍ أو أقل، أكثر لأ، بمعنى الدين بدّه يكون… يعني
+
+139
+00:11:51,930 --> 00:11:54,950
+العارية عفوا بدها تكون إما مساوية أو أقل من الدين،
+
+140
+00:11:54,950 --> 00:12:00,290
+إما مساوية أو أقل، وصلت؟ فيجب على المستعير أن لا
+
+141
+00:12:00,290 --> 00:12:06,250
+يرهن العارية بأكثر من قيمتها، علم؟ هذا الشرط الوحيد
+
+142
+00:12:06,250 --> 00:12:10,970
+إذا قلنا إن العارية تبقى عارية، علم؟ واضح في أي
+
+143
+00:12:10,970 --> 00:12:15,530
+سفسارة، لا سمح الله، طيب، نجي الآن للنقطة اللي بعدها،
+
+144
+00:12:15,530 --> 00:12:21,630
+إيها علاقة بنفس الموضوع، طبعا ما خلصنا الآن، نقلنا
+
+145
+00:12:21,630 --> 00:12:24,430
+طبعا، بناء على القول القائل إن العارية تنقلب إلى
+
+146
+00:12:24,430 --> 00:12:27,210
+ضمان للدين، لا يجوز للراهن أن يُخالف أي شرط من
+
+147
+00:12:27,210 --> 00:12:29,910
+الشروط الأربعة اللي ذكرناها، إذا قال له دينار،
+
+148
+00:12:29,910 --> 00:12:33,770
+ممنوع يكون دولار، إذا قال له خمسة آلاف، ممنوع يكون
+
+149
+00:12:33,770 --> 00:12:38,170
+بستة، ينفع يكون بأربعة، وهكذا، وإذا قال له عند فلان،
+
+150
+00:12:38,170 --> 00:12:42,270
+ممنوع يكون عند علان، وهكذا، طيب،
+
+151
+00:12:44,930 --> 00:12:48,370
+وقلنا: بناء على القول القائل إنها بتظل عارية فقط،
+
+152
+00:12:48,370 --> 00:12:52,590
+الواجب على المستعير إلا يرهن بأكثر من القيمة، وهذا
+
+153
+00:12:52,590 --> 00:12:58,610
+الكلام أيضا كنا قد انتهينا منه، وتحدثنا عنه، ليش؟
+
+154
+00:12:58,610 --> 00:13:03,330
+لأنه لا يمكن فك العارية إلا بقضاء جميع الدين، إذا
+
+155
+00:13:03,330 --> 00:13:06,530
+كان الدين أكثر منها، فعشان كده قلنا: لا يجوز رهنه
+
+156
+00:13:06,530 --> 00:13:12,670
+بأكثر من قيمته، الآن ننتقل للحديث عن نفس الموضوع،
+
+157
+00:13:29,050 --> 00:13:38,550
+طيب، الآن ماذا لو تلفت العين المُستعارة، الدهبات،
+
+158
+00:13:38,550 --> 00:13:49,210
+انسرقت الدهبات، انسرقت، في هذه الحالة يا جماعة، بدي
+
+159
+00:13:49,210 --> 00:13:55,280
+أفرّق، خليكم معايا، بدي أفرّق، طبعا خلينا الأطراف، لأنه
+
+160
+00:13:55,280 --> 00:14:01,440
+باقي نمثّل عليهم، لحظة، من المرتهن عندنا؟ أم حميد، صح؟
+
+161
+00:14:01,440 --> 00:14:02,140
+ولا لأ؟
+
+162
+00:14:04,830 --> 00:14:09,110
+وهذا هو الراهن، وهذا نخليه على جانب، إذا احتجنا،
+
+1
+
+223
+00:19:10,850 --> 00:19:15,030
+طبيعي عادي جداً خلاص، وبدي أحمد يدور له أحد يستعير
+
+224
+00:19:15,030 --> 00:19:20,920
+منه تمام، خلصنا. إذا صار الرجوع بعد القبض يعني
+
+225
+00:19:20,920 --> 00:19:25,260
+المرتهن استلمت الذهب، صارت العين المستعارة في يد
+
+226
+00:19:25,260 --> 00:19:31,200
+المرتهن، فأراد المعير أن يرجع، هل له أن يرجع أو لا؟
+
+227
+00:19:31,200 --> 00:19:34,820
+طبعاً الإجابة مبنية على أن العارية تنقلب إلى ضمان، أن
+
+228
+00:19:34,820 --> 00:19:39,000
+تبقى عارية لأنها استلمت للمرتهن، كونها استلمت، بدنا
+
+229
+00:19:39,000 --> 00:19:43,800
+نرجع، هل بقيت عارية أم انقلبت إلى ضمان للدين؟ إذا كنا
+
+230
+00:19:43,800 --> 00:19:50,590
+انقلبت إلى ضمان للدين، فليس للمعير أن يرجع، مالكش
+
+231
+00:19:50,590 --> 00:19:54,550
+ترجعي، بدك تستني، أنا أخذتهم منك وما ضحكتش عليكي،
+
+232
+00:19:54,550 --> 00:19:59,510
+قلت لك لـ 1.9 استني وغصب عنك، بدك تستني ومش من حقك
+
+233
+00:19:59,510 --> 00:20:03,770
+ترجعي، حلو؟ تمام، هذا إذا قلنا أن العارية تنقلب إلى
+
+234
+00:20:03,770 --> 00:20:09,260
+ضمان للدين، فإذا راجع المعير ليس له أن يرجع، بينما
+
+235
+00:20:09,260 --> 00:20:14,940
+إذا قلنا أن العارية تبقى عارية حتى مع كونها لأجل
+
+236
+00:20:14,940 --> 00:20:19,900
+الرهن، تبقى عارية، فهل للمعير أن يرجع أو لا؟ قولان
+
+237
+00:20:19,900 --> 00:20:25,280
+.. قولان. نعمل بمقولة العارية أنه له الرجوع، لأن
+
+238
+00:20:25,280 --> 00:20:28,220
+العارية من العقود غير اللازمة، شو يعني غير
+
+239
+00:20:28,220 --> 00:20:31,760
+اللازمة؟ يعني يحق للمعير أو المستعير أن يرجع وقت
+
+240
+00:20:31,760 --> 00:20:37,600
+ما وكيف ما شاء.  تُقرر في العارية أنها لها أن ترجع،
+
+241
+00:20:37,600 --> 00:20:42,260
+هذا الرأي الأول، الرأي الثاني وهو الأصح، يقول لا،
+
+242
+00:20:43,250 --> 00:20:48,170
+ليس لها أن ترجع. صحيح أننا نقول أن العارية بقيت عارية،
+
+243
+00:20:48,170 --> 00:20:53,190
+لكن كونها للراهن، والراهن الهدف منه توثيق، والتوثيق
+
+244
+00:20:53,190 --> 00:20:58,610
+يقتضي عدم الرجوع، إذ لا نجيز له أن يرجعها من باب
+
+245
+00:20:58,610 --> 00:21:05,290
+حفظ حق المرتهن وتوثيق حق المرتهن. بنقول لك استني لـ 1
+
+246
+00:21:05,290 --> 00:21:12,180
+.9 بعدين روح اعمل اللي بدك إياه. هذا ما يتعلق بموضوع
+
+247
+00:21:12,180 --> 00:21:17,300
+استعارة الشيء من أجل... راح نبقى على أمر يسير، اللي هو بيع
+
+248
+00:21:17,300 --> 00:21:23,120
+العين المرهونة. تحملوني قليلاً فقط، ثلاث دقائق إن شاء
+
+249
+00:21:23,120 --> 00:21:27,880
+الله، وننهي المسألة، لأنه ما في صراحة، مش كتير مقبولة
+
+250
+00:21:27,880 --> 00:21:31,040
+أن المحاضرة الجاية نيجي بس نحكي ثلاث دقائق في مسألة
+
+251
+00:21:31,040 --> 00:21:37,640
+لأن نخلصها وخلاص. صلّي على رسول الله. الآن لحظة معايا
+
+252
+00:21:37,640 --> 00:21:42,500
+كنت بتحدث عن أن المؤيد يقدر يرجع ولا لا، عرفنا
+
+253
+00:21:42,500 --> 00:21:48,480
+طيب يا ست، ما رجعتش حمدية، ما رجعتش. لكن إجا واحد
+
+254
+00:21:48,480 --> 00:21:53,980
+تسعة، إجا واحد تسعة، واحد تسعة، إيش معناه أن
+
+255
+00:21:53,980 --> 00:21:59,520
+الراهن بده يدفع الدين، ما دفعش، بدها تِباع هيك الأصل، مش
+
+256
+00:21:59,520 --> 00:22:03,080
+هاد هو الأصل في الرهن؟ جعل عين مالية وثيقة بدين
+
+257
+00:22:03,080 --> 00:22:06,900
+يستوفى منها عند تعذر الوفاء، تعذر على الراهن أن
+
+258
+00:22:06,900 --> 00:22:10,760
+يدفع، فحينها يجوز للمرتهن أن يبيعها في السوق في
+
+259
+00:22:10,760 --> 00:22:15,940
+حقه، هذا كأصل عام في الرهن. طيب، أنا الآن أتحدث عن شيء
+
+260
+00:22:15,940 --> 00:22:21,900
+مش إللي كراهن، شيء أنا مستعيره، فإيش الحل؟ جا لك الحل
+
+261
+00:22:21,900 --> 00:22:25,520
+أولاً، يعني الراهن قادر يسدّ الدين اللي عليه، إذا
+
+262
+00:22:25,520 --> 00:22:29,100
+قادر، خلاص، الفلوس هترجع له وخلصنا، يعني الدهب
+
+263
+00:22:29,100 --> 00:22:33,940
+هيرجعوا وخلصنا، وبيعطيهم لحمدية وخلصنا. طيب، عجز الراهن؟
+
+264
+00:22:33,940 --> 00:22:39,760
+فلمّا يعجز الراهن، مطلوب منه لازم يروح
+
+265
+00:22:39,760 --> 00:22:43,940
+للمعير. بدي أروح هان في المثال لحمدي، ياخد كمان كاسة
+
+266
+00:22:43,940 --> 00:22:48,660
+ويروح لها يقول لها: أنا وعدتك، وأنت عارفة أني لما
+
+267
+00:22:48,660 --> 00:22:51,880
+اتدينت كنت موعود أنه في فلوس تجيني، وأنا ما كذبت
+
+268
+00:22:51,880 --> 00:22:55,000
+عليكي، لكن صار الظروف، ابصر إيش صار، في حصار صار في
+
+269
+00:22:55,000 --> 00:22:59,160
+عمليات، منعت من أن فلوس تدخل غزة، وإلى غير ذلك
+
+270
+00:22:59,160 --> 00:23:06,970
+فصراحة، دهباتك في خطر. إيش يعني؟ هينباعوا، فإما تيجي
+
+271
+00:23:06,970 --> 00:23:11,170
+في معايا، إذا دهباتك عزيزين عليك، يرجعوا لك، أنه
+
+272
+00:23:11,170 --> 00:23:15,790
+تنحريهم، شو يعني؟ يعني أنت تسدّ الدين عني من فلوسك
+
+273
+00:23:15,790 --> 00:23:21,320
+الخاصة. مش معناه أنا بدي أضحك عليها، لأ، فيه فلوسها
+
+274
+00:23:21,320 --> 00:23:23,860
+هيظلوا، هيصير فيه دين بالنسبة لها، وإلى
+
+275
+00:23:23,860 --> 00:23:27,320
+غير ذلك، هيصير فيه عقد ثاني، لكن أنا أتحدث، هي
+
+276
+00:23:27,320 --> 00:23:30,800
+هتفهم معايا إذا الدهبات عزيزين عليها. لحظة أنا...
+
+277
+00:23:30,800 --> 00:23:33,940
+أنا تعمدت أحكي هذا المثال، عشان أقول لك أنه ممكن
+
+278
+00:23:33,940 --> 00:23:37,700
+بالنسبة لها ما فيش مجال إنها تبيع الدهب، هدول ذكرى من
+
+279
+00:23:37,700 --> 00:23:40,720
+والدها، الذي توفي مثلاً، أو... أو... إلى
+
+280
+00:23:40,720 --> 00:23:46,550
+غير ذلك. فإذا معنية تسترد الدهبات، بتدبر حالها، ولو
+
+281
+00:23:46,550 --> 00:23:50,870
+هي بتاخد من أهلها، من كذا، ولو هي مش مشغولة
+
+282
+00:23:50,870 --> 00:23:55,430
+بالمناسبة. لكن عأساس الدهب هيك هيك هينباع لو ما
+
+283
+00:23:55,430 --> 00:24:00,510
+انْدفعش الدين. فالآن هي راح تفتح الدنيا عليّ، لأنها
+
+284
+00:24:00,510 --> 00:24:04,270
+ما بدها الدهب ينباع، رجع لها الدهب، بعدين بدي يصير
+
+285
+00:24:04,270 --> 00:24:09,990
+بينها وبين المستعير عقد آخر، أنه بده فيه دين، و
+
+286
+00:24:09,990 --> 00:24:13,750
+طالب، و... ابصر شو. وأنا لاحظت، صحيح، في المثال، جولة حمدية
+
+287
+00:24:13,750 --> 00:24:18,070
+كزوجه له، مش ضرورة تكون زوجة، تمام، ممكن صديق،
+
+288
+00:24:18,070 --> 00:24:22,030
+ممكن جار، ممكن قريب، بغض النظر، فبدي يصير في عقد جديد
+
+289
+00:24:22,030 --> 00:24:26,060
+بيناتهم، بعدين بتحسبوا عليه. المهم، خلصنا الرهن. هذا
+
+290
+00:24:26,060 --> 00:24:29,460
+إذا رضيت، اتسدّ الدين، ما رضيتش، جالَت، وأنا شو
+
+291
+00:24:29,460 --> 00:24:33,760
+يجبرني، ما ليش علاقة، ابصر شو، ما بعرف شو. فالآن، شئتِ
+
+292
+00:24:33,760 --> 00:24:38,680
+أم أبيتِ، حينباع، لأن هذا وثيقة لإيش؟ للمرتهن، إن شو
+
+293
+00:24:38,680 --> 00:24:43,410
+ذنبه، ما تقولي لي طبعاً ذنبها، ما لها علاقة أصلاً، قصة
+
+294
+00:24:43,410 --> 00:24:46,270
+تشوفوا يا جماعة في مسألة برضه مهمة، بدنا ننبه لها
+
+295
+00:24:46,270 --> 00:24:51,910
+أنت، لأن كونك عرفت لما قعدت أن هذا للراهن، بدك تعرف
+
+296
+00:24:51,910 --> 00:24:55,690
+أن الراهن ممكن ينباع هذا الشيء، بدي يكون في ذهنك
+
+297
+00:24:55,690 --> 00:24:59,710
+أصلاً أنه ممكن ينباع، ولا شو الهدف من الرهن؟ فأنت من
+
+298
+00:24:59,710 --> 00:25:04,170
+البداية، جازفت، أنت من البداية، خطرت ببالك أنه ممكن
+
+299
+00:25:04,170 --> 00:25:08,190
+فعندك وارد هذا الشيء، فبالتالي مش من حقك تعترض
+
+300
+00:25:09,470 --> 00:25:13,930
+وبالتالي الآن كل الطرق استُنْفِذت، وما قدرنا نشدّ
+
+301
+00:25:13,930 --> 00:25:18,870
+الدين، فالآن بده ينباع الدهب. طيب، لما ينباع الدهب،
+
+302
+00:25:18,870 --> 00:25:25,530
+المعير بده يطالب المستعير بشو؟ بالثمن أم بالقيمة؟
+
+303
+00:25:25,530 --> 00:25:29,410
+ممكن واحدة تقول هي هي، بقول لك: لا، مش هي هي، الآن أنا
+
+304
+00:25:29,410 --> 00:25:36,050
+ممكن أروح أبيع الدهب الآن بعشرة آلاف دولار، مع أنه
+
+305
+00:25:36,050 --> 00:25:42,210
+قيمتهم 8000، أو أبيعهم بـ 7000، وقيمتهم 9000، فمش
+
+306
+00:25:42,210 --> 00:25:46,470
+دائماً الثمن مساوي للقيمة. وبالتالي، نرجع نقول الآن،
+
+307
+00:25:46,470 --> 00:25:49,970
+إذا باعوا، المعير بعد البيع، مش المعير إللي له
+
+308
+00:25:49,970 --> 00:25:53,310
+حاجة عند المستعير، قيمة الدهب، صح ولا لأ؟ أو ثمن
+
+309
+00:25:53,310 --> 00:25:59,050
+الذهب؟ فبدنا نقول: بناءً على القول القائل أن العارية
+
+310
+00:25:59,050 --> 00:26:06,670
+من أجل الرهن تنقلب إلى ضمان للدين، فإن المعير يطالب
+
+311
+00:26:06,670 --> 00:26:12,710
+المستعير بالثمن الذي بِيعت به. هذا إذا قلنا أنها
+
+312
+00:26:12,710 --> 00:26:17,790
+تنقلب إلى ضمان للدين، يطالب بالثمن سواء بيعت بأكثر
+
+313
+00:26:17,790 --> 00:26:22,010
+من قيمتها أو بأقل، يعني الدهب كانوا بيساووا 8000،
+
+314
+00:26:22,620 --> 00:26:26,860
+سواء باعه بتسعة أو باعه بسبعة، أنت إللي بدك تطالبه
+
+315
+00:26:26,860 --> 00:26:30,660
+بالثمانية، اللي هو الثمن اللي بِيعت به. المعير يطالب
+
+316
+00:26:30,660 --> 00:26:34,120
+بالثمن، هذا على الرأي القائل أن العارية تنقلب إلى
+
+317
+00:26:34,120 --> 00:26:38,140
+ضمان للدين. أما بناءً على القول القائل أن العارية
+
+318
+00:26:38,140 --> 00:26:42,220
+تبقى عارية، فإن المعير يطالب بالقيمة بغض النظر عن
+
+319
+00:26:42,220 --> 00:26:46,360
+الثمن اللي بِيعت به. يعني إن باعوا الذهب بثمن ثلاثة،
+
+320
+00:26:46,360 --> 00:26:50,420
+وقيمتهم عشرة، بدي أطالبه بالعشرة. إن باعوا بثمانية، و
+
+321
+00:26:50,420 --> 00:26:54,900
+قيمتهم ستة، بدي أطالبه بالستة. وصلت؟ يطالب بالقيمة إذا
+
+322
+00:26:54,900 --> 00:26:59,100
+قلنا عارية تبقى عارية، يطالب بالثمن إذا قلنا تنقلب
+
+323
+00:26:59,100 --> 00:27:04,400
+إلى ضمان للدين. هذا ما يتعلق بالركن الثالث من أركان
+
+324
+00:27:04,400 --> 00:27:09,260
+الرهن، وكل ما يتعلق به من مسائل. المحاضرة القادمة
+
+325
+00:27:09,260 --> 00:27:12,900
+بإذن الله، سنتحدث حول الركن الرابع من أركان الرهن،
+
+326
+00:27:13,020 --> 00:27:17,480
+ألا وهو المرهون به. أقول قولي هذا وأستغفر الله لي
+
+327
+00:27:17,480 --> 00:27:22,460
+ولكم. وصلى الله وسلم وبارك على سيدنا محمد، والسلام
+
+328
+00:27:22,460 --> 00:27:24,820
+عليكم ورحمة الله تعالى وبركاته
diff --git a/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/txDyDU5RFjs.srt b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/txDyDU5RFjs.srt
new file mode 100644
index 0000000000000000000000000000000000000000..542c6a0d8efe81403f102913d176926d657c60c9
--- /dev/null
+++ b/PL9fwy3NUQKwZf4TeRaPyrz4JEiVT-dkis/txDyDU5RFjs.srt
@@ -0,0 +1,650 @@
+1
+00:00:05,110 --> 00:00:07,910
+أعوذ بالله من الشيطان الرجيم، بسم
+
+2
+00:00:07,910 --> 00:00:11,230
+الله الرحمن الرحيم، الحمد لله رب العالمين، والصلاة
+
+3
+00:00:11,230 --> 00:00:14,730
+والسلام على أشرف الأنبياء والمرسلين، سيدنا محمد بن
+
+4
+00:00:14,730 --> 00:00:18,210
+عبد الله الصادق الأمين، ثم أما بعد، أحييكم جميعا
+
+5
+00:00:18,210 --> 00:00:21,650
+بتحية الإسلام، فالسلام عليكم ورحمة الله تعالى
+
+6
+00:00:21,650 --> 00:00:26,580
+وبركاته، كيف حالكم؟ طيبات إن شاء الله؟  أتمنى أن تكونوا قد حضرتم جيدا إن
+
+7
+00:00:26,580 --> 00:00:31,700
+شاء الله، طيب عظيم، إذًا لازلنا نتحدث حول مقدمة عامة
+
+8
+00:00:31,700 --> 00:00:36,440
+في الحديث عن العقود إجمالا، كنا قد تحدثنا في المحاضرة
+
+9
+00:00:36,440 --> 00:00:41,040
+السابقة حول مفهوم العقد بمعناه العام، وكذا بمعناه
+
+10
+00:00:41,040 --> 00:00:46,260
+الخاص، ثم تحدثنا عن أركانه، اليوم بإذن الله سنتحدث
+
+11
+00:00:46,260 --> 00:00:52,260
+عن تقسيماته، ونقول إن أي عقد من العقود، بغض النظر عن
+
+12
+00:00:52,260 --> 00:00:59,520
+اسمه، ينقسم بعدة اعتبارات، فينقسم باعتبار الصحة إلى
+
+13
+00:00:59,520 --> 00:01:04,220
+عقد صحيح، وعقد غير صحيح.
+
+14
+00:01:05,950 --> 00:01:12,730
+فالعقد غير الصحيح أيضا اختلف فيه العلماء، الجمهور
+
+15
+00:01:12,730 --> 00:01:18,430
+يعتبرون العقد غير الصحيح دائما باطلا، بينما الحنفية
+
+16
+00:01:18,430 --> 00:01:25,470
+فرقوا في العقد غير الصحيح إلى عقد فاسد، وعقد باطل.
+
+17
+00:01:25,470 --> 00:01:29,810
+فخلونا نشوف إيش المقصود من هذه العقود قبل التقسيمة
+
+18
+00:01:29,810 --> 00:01:35,320
+الثانية، فلحظي معي حينما نتحدث عن تقسيم العقد
+
+19
+00:01:35,320 --> 00:01:40,380
+باعتبار صحته، نقول هناك عقد صحيح، لحظي لما أقول عقد
+
+20
+00:01:40,380 --> 00:01:45,840
+صحيح، يعني هو ذلك العقد الذي استوفى كل أركانه وشروطه
+
+21
+00:01:45,840 --> 00:01:48,860
+الأركان التي تحدثنا عنها قبل قليل، مع شروطها
+
+22
+00:01:48,860 --> 00:01:54,470
+مستوفاة، أو التي تحدثنا عنها في المحاضرة السابقة، تحدثنا
+
+23
+00:01:54,470 --> 00:01:59,390
+أن أي عقد له ثلاثة أركان: صيغة، وعقد، ومعقود عليه،
+
+24
+00:01:59,390 --> 00:02:05,710
+وأيضا شروط لكل ركن من هذه الأركان، فإذا ما استوفاه
+
+25
+00:02:05,710 --> 00:02:09,690
+هذا العقد، كان عقدا صحيحا، وحينما أقول عقد صحيح، إذا
+
+26
+00:02:09,690 --> 00:02:15,690
+تترتب عليه آثاره فورا، بمجرد انعقاده تترتب
+
+27
+00:02:15,690 --> 00:02:20,110
+عليه آثاره، وهذه الآثار سنتحدث عنها تباعا عند
+
+28
+00:02:20,110 --> 00:02:26,090
+حديثنا عن العقود بشكل أو بشيء من التفصيل، أما
+
+29
+00:02:26,090 --> 00:02:30,690
+بالنسبة للعقد غير الصحيح، جمهور العلماء دائما دائما
+
+30
+00:02:30,690 --> 00:02:34,510
+عندهم العقد غير الصحيح هو الباطل، فلم يفرقوا بين
+
+31
+00:02:34,510 --> 00:02:38,170
+فاسد وباطل، وبالتالي سواء قلنا فاسد أو باطل، ما في
+
+32
+00:02:38,170 --> 00:02:43,540
+فرق بالنسبة لجمهور العلماء، فقالوا إن العقد غير
+
+33
+00:02:43,540 --> 00:02:48,780
+الصحيح هو ذلك العقد الذي حدث فيه خلل إما في أركانه
+
+34
+00:02:48,780 --> 00:02:53,300
+أو في شروطه، صار في عندي أي خلل في الأركان أو في
+
+35
+00:02:53,300 --> 00:02:57,620
+الشروط، هذا العقد يعد باطلا، زي ما قلنا مثلا في
+
+36
+00:02:57,620 --> 00:03:01,760
+المحاضرة السابقة، بيع السمك في الماء، يعتبر باطلا، ولا
+
+37
+00:03:01,760 --> 00:03:04,740
+لا؟  نعم، باطل، ليش؟ لأنه فيه خلل في الشروط، صح
+
+38
+00:03:04,740 --> 00:03:08,840
+ولا لا؟ بيع الطير في الهواء أيضا يعد باطلا، بيع
+
+39
+00:03:08,840 --> 00:03:12,460
+المجنون يعد باطلا، ليش؟ لأن المجنون لا أهلية له،
+
+40
+00:03:12,460 --> 00:03:16,280
+ونحن نقول إن الأهلية شرط في العاقد، وهكذا، فهمتم؟
+
+41
+00:03:16,280 --> 00:03:22,880
+تمام، أما الحنفية ففرقوا بين الفاسد والباطل، فقالوا
+
+42
+00:03:22,880 --> 00:03:26,740
+العقد غير الصحيح ليس دائما باطلا، قد يكون فاسدا، وقد
+
+43
+00:03:26,740 --> 00:03:31,480
+يكون باطلا، فأما الباطل هو نفس مقال الجمهور، أنه فيه
+
+44
+00:03:31,480 --> 00:03:35,380
+خلل إما في الأركان أو في الشروط، في خلل إما في
+
+45
+00:03:35,380 --> 00:03:38,880
+الأركان أو في الشروط، هذا يعد باطلا عند الحنفية،
+
+46
+00:03:38,880 --> 00:03:43,120
+أما الفاسد عندهم فهو أنه ما فيه خلل في الأركان و
+
+47
+00:03:43,120 --> 00:03:49,160
+الشروط، لكن فيه خلل خارج عن ماهية العقد، مثلا جاءك
+
+48
+00:03:49,160 --> 00:03:52,760
+أنه أنا أروح أشتري شغلة بثمن عشرة، وأشتريها
+
+49
+00:03:52,760 --> 00:04:00,920
+بمئتين، غبن فاحش،  يُكتشف في هذا العقد، فاسد، إيش حكمه؟ جاءك
+
+50
+00:04:00,920 --> 00:04:06,460
+إذا البيع رجّع للزيادة، إنْ رجع انقلب صحيحًا، وإلا أصبح باطلاً.
+
+51
+00:04:06,460 --> 00:04:11,180
+فهمتم؟ هذا بالنسبة للفاسد، فلذلك الحنفية يقولون أن
+
+52
+00:04:11,180 --> 00:04:16,300
+الباطل هو ما لم يشرع لا بأصله ولا بوصفه، أما الفاسد
+
+53
+00:04:16,300 --> 00:04:21,530
+ما شرع بأصله دون وصفه، تمام؟ هذا بالنسبة للتقسيمة
+
+54
+00:04:21,530 --> 00:04:25,770
+الأولى، التي هي باعتبار صحة العقد من عدمه، أيضا
+
+55
+00:04:25,770 --> 00:04:30,850
+ينقسم العقد باعتبار آخر، وهو باعتبار النفاذ وعدم
+
+56
+00:04:30,850 --> 00:04:37,770
+النفاذ، إلى قسمين: عقد نافذ، وعقد غير نافذ، الذي
+
+57
+00:04:37,770 --> 00:04:44,750
+نسميه موقوفًا، موقوف، فالعقد النافذ هو العقد الذي يصدر
+
+58
+00:04:44,750 --> 00:04:49,850
+من ذي الأهلية والولاية، صدر من إنسان لديه أهلية
+
+59
+00:04:49,850 --> 00:04:55,910
+ولدييه ولاية، وبالتالي بمجرد صدوره ينفذ، بمعنى لا
+
+60
+00:04:55,910 --> 00:05:02,080
+يتوقف على إجازة الغير، لا يتوقف، يعني أنا لما بدي
+
+61
+00:05:02,080 --> 00:05:07,020
+أبيع هذا الجوال، وأنت اشتريته مني... مني، فليس لازم
+
+62
+00:05:07,020 --> 00:05:11,320
+أحد يجي يقول لنا okay، ماشي، بيعكم صحيح، خلاص تلقائيًا
+
+63
+00:05:11,320 --> 00:05:16,720
+يصبح نافذا، شو يعني؟ يعني تترتب عليه آثاره، أما
+
+64
+00:05:16,720 --> 00:05:26,200
+غير النافذ هو العقد الذي يصدر من شخص ليس لديه ولاية،
+
+65
+00:05:26,200 --> 00:05:30,720
+مثلا، كالفضولي، كالفضولي، من هو الفضولي؟  قال لك
+
+66
+00:05:30,720 --> 00:05:37,660
+الفضولي هو الذي يتصرف في مال غيره دون إذن منه،
+
+67
+00:05:37,660 --> 00:05:43,140
+نقول عنه تصرف فضولي، شو يعني؟ يعني هذا التصرف
+
+68
+00:05:43,140 --> 00:05:49,610
+الذي صدر منه، لا ينفذ إلا بإجازة الغير، فإن أجازه
+
+69
+00:05:49,610 --> 00:05:54,810
+صاحبه، أصبح نافذا، وإلا إيش؟ لا ينفذ، عشان هيك سميناه
+
+70
+00:05:54,810 --> 00:05:59,650
+موقوفًا، موقوف على إجازة الغير، بخلاف النافذ الذي لا
+
+71
+00:05:59,650 --> 00:06:04,610
+يتوقف على إجازة الغير، فهمتم؟ أما بالنسبة للتقسيمة
+
+72
+00:06:04,610 --> 00:06:11,150
+الثالثة، عندي بنقول من حيث اللزوم، لدينا عقد لازم،
+
+73
+00:06:11,150 --> 00:06:21,260
+وعقد غير لازم، العقد اللازم ينقسم لقسمين عندي: عقد
+
+74
+00:06:21,260 --> 00:06:29,080
+لازم لا يقبل الفسخ بالإقالة، وعقد لازم يقبل الفسخ
+
+75
+00:06:29,080 --> 00:06:38,560
+بالإقالة، العقد اللازم الذي لا يقبل الفسخ بالإقالة،
+
+76
+00:06:39,720 --> 00:06:47,520
+مثاله فقط عقد الزواج، فعقد الزواج يا جماعة عقد لازم،
+
+77
+00:06:47,520 --> 00:06:52,140
+ولا يمكن فسخه بالإقالة، بالإقالة يعني اتفاق الطرفين
+
+78
+00:06:52,140 --> 00:06:56,940
+على إزالة العقد، الإقالة هو رفع وإزالة العقد بالتراضي،
+
+79
+00:06:56,940 --> 00:07:02,880
+هي الإقالة، فالآن عقد النكاح لازم، لكن لا يقبل الفسخ
+
+80
+00:07:02,880 --> 00:07:10,020
+بالإقالة، بمعنى متى ما تم العقد بين الزوجين، ما
+
+81
+00:07:10,020 --> 00:07:16,320
+يصير لأحدهما أن يتراجع، ما يصير الزوجة بعد أن عقد
+
+82
+00:07:16,320 --> 00:07:20,780
+قيرانها، بمصطلح العرف اليوم، عقد قيران، عقد قيرانها،
+
+83
+00:07:20,780 --> 00:07:25,980
+ما يصير تقول خلاص بطلت اللعب، بدي أروح عند ماما،
+
+84
+00:07:25,980 --> 00:07:30,500
+لا يا ماما، تأبيدة، هذه خلاص تأبيدة على طول، فنقول لك ما
+
+85
+00:07:30,500 --> 00:07:35,400
+هو فيه طلاق، فيه كذا، فيه كذا، لكن الفسخ معناته أنه
+
+86
+00:07:35,400 --> 00:07:41,600
+يعود بالعقد إلى ما كان عليه الحال قبل ذلك، هي الزوجة
+
+87
+00:07:41,600 --> 00:07:47,370
+التي طلقت حتى قبل الدخول، هل ترجع تماما مثلها مثل
+
+88
+00:07:47,370 --> 00:07:51,610
+أي واحدة لم يُعقد عليها؟ بالتأكيد لا، في حقوق، في
+
+89
+00:07:51,610 --> 00:07:56,030
+التزامات، في أشياء كثيرة تتغير، صح ولا لا؟ فلذلك،
+
+90
+00:07:56,030 --> 00:07:59,450
+فلا يُفسخ بالإقالة، لأنه فسخ بالإقالة، معناته
+
+91
+00:07:59,450 --> 00:08:03,350
+بدنا نرجع مثل ما كنا تمامًا،  هنالك لا يوجد رجوع، متى
+
+92
+00:08:03,350 --> 00:08:07,750
+ما تم تمامًا، حلو؟ عشان كده عقد الزواج هو العقد
+
+93
+00:08:07,750 --> 00:08:13,170
+الوحيد الذي له مقدمات، عشان كده الشريعة أولته من
+
+94
+00:08:13,170 --> 00:08:17,730
+الأهمية ما لم توليه في العقود الأخرى، جعلت له خطبة،
+
+95
+00:08:17,730 --> 00:08:22,130
+و...إلى غير ذلك، على أساس الذي يقدم على هذا العقد
+
+96
+00:08:22,130 --> 00:08:26,210
+يكون عارف هو أين رايح، لكن في البيع أنا ممكن أشتري
+
+97
+00:08:26,210 --> 00:08:30,170
+شيئا وأندم، okay، وارد، ليش؟ لأنه ما فيه مقدمات ولا
+
+98
+00:08:30,170 --> 00:08:33,430
+شيء، في الزواج؟ لا، أنت بدك تكون لما بدك تقدم على
+
+99
+00:08:33,430 --> 00:08:39,320
+هيك خطوة، تفكر ألف مرة، فهمتم؟ تمام، عشان هيك
+
+100
+00:08:39,320 --> 00:08:42,840
+يعني في بنات،  يا جماعة، خلاص عندها الزواج بدلة
+
+101
+00:08:42,840 --> 00:08:48,340
+بيضة، لا يا ماما،  أه، موجود، الأثر موجود، فلأ، الزواج ليس
+
+102
+00:08:48,340 --> 00:08:52,200
+هيك أبدا، مسؤولية كبيرة، ليس بدلة بيضة، البدلة البيضة
+
+103
+00:08:52,200 --> 00:08:58,370
+ساعتين ثلاث بخلص مفعولها، تمام؟ طيب، لازم لا يقبل
+
+104
+00:08:58,370 --> 00:09:03,810
+الفسخ بالإقالة، في عندي لازم يقبل الفسخ بالإقالة،
+
+105
+00:09:03,810 --> 00:09:10,210
+كعقد البيع مثلا، عقد البيع أصله أنه لازم، شو يعني؟
+
+106
+00:09:10,210 --> 00:09:16,230
+يعني ممنوع نتراجع، ممنوع أن أتراجع إلا برضى الطرفين،
+
+107
+00:09:16,230 --> 00:09:20,050
+إلا برضى الطرفين، يعني أنا اشتريت منك شيء وما في
+
+108
+00:09:20,050 --> 00:09:25,050
+خيارات ولا أي شيء، يجوز أرجعها غصبا عنك؟ لا، إذا رضيتِ
+
+109
+00:09:25,050 --> 00:09:30,060
+مّا رضيتِ، خلاص أنا الذي أتحمل المسؤولية، لكن بالتراضي
+
+110
+00:09:30,060 --> 00:09:35,240
+نقدر نتراجع، فما في أي مشكلة، هذا نقول عنه لازم لكن
+
+111
+00:09:35,240 --> 00:09:39,700
+يَقبل الفسخ بالإقالة، لازم يعني ما فيه مجال للتراجع إلا
+
+112
+00:09:39,700 --> 00:09:45,120
+بالتراضي، إلا برضى الطرف الآخر، حلو، العقد غير اللازم
+
+113
+00:09:45,120 --> 00:09:49,380
+كمان قسمين، في عندي غير لازم من كلا الطرفين، من
+
+114
+00:09:49,380 --> 00:09:52,520
+الاثنين، وفي عندي غير لازم من طرف، ولما أقول غير
+
+115
+00:09:52,520 --> 00:09:57,790
+لازم من الطرف، يعني لازم من الطرف الآخر، غير لازم من
+
+116
+00:09:57,790 --> 00:10:03,790
+كلا الطرفين، زي مثلا الوكالة، الوكالة عقد غير لازم
+
+117
+00:10:03,790 --> 00:10:09,690
+من كلا الطرفين، عادي جدا أنا أوكلّك تبيعِ جوالي، وأنا
+
+118
+00:10:09,690 --> 00:10:13,590
+أتراجع أنا كموكل، وعادي أنتي تتراجعي كوكيل، ما في
+
+119
+00:10:13,590 --> 00:10:19,350
+مشكلة، في العارية، الإعارة، عادي جدا أُعيرك كتابي،
+
+120
+00:10:19,350 --> 00:10:24,010
+تدرسي منه، وأرجع بعد ساعة أقول لك بدي إياه، عندي امتحان،
+
+121
+00:10:24,010 --> 00:10:29,530
+عادي جدا أنتي ترديه، وهكذا، فنقول عنه عقد غير
+
+122
+00:10:29,530 --> 00:10:36,130
+لازم، يحق لكلا الطرفين فسخه دون رضا الطرف الآخر، حلو؟
+
+123
+00:10:36,450 --> 00:10:42,390
+لكن في عندي عقد غير لازم بس من جهة واحدة، يعني في
+
+124
+00:10:42,390 --> 00:10:48,990
+حق للآخر لازم، زي عقد الرهن، الرهن في حق المرتهن غير
+
+125
+00:10:48,990 --> 00:10:53,770
+لازم، في حق المرتهن... المرتهن، عادي أنا آخذ جوالك
+
+126
+00:10:53,770 --> 00:10:58,130
+رهنا بالمال اللي إيه اللي عندك، كمرتهن وأخبيه عندي،
+
+127
+00:10:59,170 --> 00:11:03,670
+عادي جدا بعد يومين أقول له أنا خلاص، وبيضل حقي عند
+
+128
+00:11:03,670 --> 00:11:09,070
+الله، وخلاص وما بدّيش إياه، ينفع؟  نعم، ينفع، لكن
+
+129
+00:11:09,070 --> 00:11:13,270
+الراهن متى ما سَلَّمني جوالي،  لا يمكن إرجاعه إلا إذا
+
+130
+00:11:13,270 --> 00:11:17,110
+أنا راضٍ، فهمتم؟ تمام، هات، بالنسبة لي التقسيمة
+
+131
+00:11:17,110 --> 00:11:23,660
+الثالثة، نجي للتقسيمة الرابعة، و بها نختم، هي أن من
+
+132
+00:11:23,660 --> 00:11:28,820
+حيث التنجيز والإضافة والتعليق، ينقسم العقد لثلاثة
+
+133
+00:11:28,820 --> 00:11:35,120
+أقسام: عقد ناجز، أو منجز نسميه، وعقد مضاف إلى
+
+134
+00:11:35,120 --> 00:11:41,200
+المستقبل، وعقد معلق على شرط، لحظة، بدي أرجع أقول أنا
+
+135
+00:11:41,200 --> 00:11:46,220
+هنا أتحدث عن العقود إجمالا، لأن مثلا في عقد البيع
+
+136
+00:11:46,220 --> 00:11:49,500
+ممنوع يكون فيه إضافة، وممنوع يكون فيه تعليق، عسى
+
+137
+00:11:49,500 --> 00:11:53,160
+كده لما أجيب هجيب أمثلة، ما تقول لي قدام حينما
+
+138
+00:11:53,160 --> 00:11:57,140
+أتحدث عن البيع بأنه...طب أنت حكيت شيء ثاني، لا، هنا
+
+139
+00:11:57,140 --> 00:12:02,320
+أتحدث عن العقود إجمالًا، طبعا لكن مثلا العقود الأخرى
+
+140
+00:12:02,320 --> 00:12:06,020
+البيع، لها أحكامها الخاصة بها، وبالتالي ممكن
+
+141
+00:12:06,020 --> 00:12:09,580
+نلاقي في عندي عقد ناجز، ممكن نلاقي عقد مضاف إلى
+
+142
+00:12:09,580 --> 00:12:14,300
+المستقبل، وفي عندي عقد معلق على شرط، يعني مثلا
+
+143
+00:12:14,300 --> 00:12:18,080
+الوصية مضافة إلى المستقبل، صح ولا لا؟ لأن الوصية
+
+144
+00:12:18,080 --> 00:12:23,160
+كعقد متوقف على موتي، صح ولا لا؟ هي الوصية على موتي،
+
+145
+00:12:23,160 --> 00:12:27,220
+فيصبح نفاذ العقد بعد الموت، إذًا مضاف ولا مش مضاف؟
+
+146
+00:12:27,220 --> 00:12:33,790
+بلى، مضاف، كمان أجي مثلا في موضوع الإيجار، أعلق
+
+147
+00:12:33,790 --> 00:12:38,490
+الإيجار على شرط، ينفع؟ نعم، ينفع، عادي جدا أجي أقول لك
+
+148
+00:12:38,490 --> 00:12:44,290
+مثلا، سأُؤجّرُك بيتي إذا جاء شهر كذا كذا، مثلا، ينفع،
+
+149
+00:12:44,290 --> 00:12:51,650
+برضه ما في مشكلة، لكن في عندي عقد ناجز، أنه بعت لك هذا
+
+150
+00:12:51,650 --> 00:12:55,950
+القلم بعشرة شواكل، وأنت قبلت، بدون لا شرط ولا تعليق،
+
+151
+00:12:55,950 --> 00:13:00,470
+ولا تأجيل ولا أي شيء، ينفع؟ نعم، طبعا ينفع، فلذلك نقول
+
+152
+00:13:00,470 --> 00:13:05,530
+في عندي عقد ناجز أو منجز، عندي عقد معلق على شرط،
+
+153
+00:13:05,530 --> 00:13:09,430
+وعندي عقد مضاف إلى المستقبل، بالنسبة لحكم كل عقد من
+
+154
+00:13:09,430 --> 00:13:14,610
+هذه العقود، إن العقد الناجز أو المنجز تترتب عليه
+
+155
+00:13:14,610 --> 00:13:22,510
+آثاره بمجرد انعقاده، ليش؟ بمعنى أنه ينعقد في الحال،
+
+156
+00:13:22,510 --> 00:13:28,230
+وفورا،  الانعقاد تترتب عليه آثاره، بمعنى لا يتوقف على
+
+157
+00:13:28,230 --> 00:13:35,370
+شرط أو على أجل، مباشرة، إيش؟ يُعد هذا العقد منعقدا،
+
+158
+00:13:36,260 --> 00:13:41,640
+عشان كده سميناه ناجزا، تنجيز من اسمه، يعني حالا، أما
+
+159
+00:13:41,640 --> 00:13:46,660
+بالنسبة للعقد المضاف إلى المستقبل، فهذا العقد لا
+
+160
+00:13:46,660 --> 00:13:53,660
+تترتب عليه آثاره، ولا ينعقد إلا بمجيء الزمن، إلا
+
+161
+00:13:53,660 --> 00:13:58,740
+بمجيء الزمن، قبل مجيء الزمن كأنه غير موجود، نفس الأمر،
+
+162
+00:13:58,740 --> 00:14:03,820
+يقال بالنسبة للعقد المعلق على شرط، فإن هذا العقد لا
+
+163
+00:14:03,820 --> 00:14:0
\ No newline at end of file
diff --git a/PL9fwy3NUQKwboNQTWPePHoN8dlQDul_Y4/7RLTZqZakq8.srt b/PL9fwy3NUQKwboNQTWPePHoN8dlQDul_Y4/7RLTZqZakq8.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f558b6ccb65a3ed602ffee91bb68821c4c616499
--- /dev/null
+++ b/PL9fwy3NUQKwboNQTWPePHoN8dlQDul_Y4/7RLTZqZakq8.srt
@@ -0,0 +1,994 @@
+1
+00:00:19,440 --> 00:00:23,860
+أعزاء الطلبة اليوم موضوعنا محاسبة المسئولية وتقييم 
+
+2
+00:00:23,860 --> 00:00:29,480
+الأداء محاسبة المسئولية 
+
+3
+00:00:29,480 --> 00:00:36,720
+وتقييم الأداء 
+
+4
+00:00:36,720 --> 00:00:47,460
+responsibility 
+
+5
+00:00:47,460 --> 00:00:48,480
+accounting
+
+6
+00:01:02,650 --> 00:01:13,750
+and performance evaluation
+
+7
+00:01:13,750 --> 00:01:21,910
+موضوع 
+
+8
+00:01:21,910 --> 00:01:28,870
+محاسبة المسئولية وتقييم الأداء وقبل أن نبدأ في
+
+9
+00:01:28,870 --> 00:01:33,070
+محاسبة المسئولية وتقييم الأداء لابد أن نعرج على 
+
+10
+00:01:33,070 --> 00:01:38,010
+اللامركزية على اللا مركزية
+
+11
+00:02:01,090 --> 00:02:08,110
+decentralization طيب الآن تعريف اللامركزية تعريف 
+
+12
+00:02:08,110 --> 00:02:23,970
+اللامركزية تعرف المركزية بأنها تفويت بعض 
+
+13
+00:02:23,970 --> 00:02:31,440
+صلاحيات اتخاذ القرارات بأنها تفويت بعض صلاحيات 
+
+14
+00:02:31,440 --> 00:02:36,860
+اتخاذ القرارات من قبل الإدارة العليا الـ Top 
+
+15
+00:02:36,860 --> 00:02:37,320
+Management
+
+16
+00:02:39,920 --> 00:02:46,120
+للإدارة الدنيا والوسطى للإدارة الدنيا والوسطى إذا
+
+17
+00:02:46,120 --> 00:02:52,180
+تعرف اللامركزية بأنها تفويت بعض السلطات اتخاذ 
+
+18
+00:02:52,180 --> 00:02:57,360
+القرارات صلاحيات اتخاذ القرارات من قبل الإدارة 
+
+19
+00:02:57,360 --> 00:03:05,860
+العليا للمستويات الدنيا والوسطى هذا بالنسبة لتعريف 
+
+20
+00:03:05,860 --> 00:03:08,780
+اللامركزية نأتي 
+
+21
+00:03:10,080 --> 00:03:16,360
+نذكر هنا عبارة أخرى تختلف اللامركزية من مؤسسة إلى 
+
+22
+00:03:16,360 --> 00:03:23,780
+أخرى تختلف درجة اللامركزية من مؤسسة إلى أخرى 
+
+23
+00:03:30,240 --> 00:03:33,640
+من مؤسسة أو من منشأة إلى منشأة إلى أخرى يعني تختلف 
+
+24
+00:03:33,640 --> 00:03:37,800
+اللامركزية اللا مركزية من جامعة إلى جامعة أخرى 
+
+25
+00:03:37,800 --> 00:03:41,100
+حسب كل واحد أيش رؤية الـ top management اللي هم 
+
+26
+00:03:41,100 --> 00:03:47,040
+فوضوا الصلاحيات يعني مثلا في اللي هو في الـ .. في 
+
+27
+00:03:47,040 --> 00:03:52,060
+الجامعة مثلا يقولك أن مثلا لا عند العمادة تتوقع 
+
+28
+00:03:52,060 --> 00:03:56,980
+الدرجات و تترحل على مثل القبول والتسجيل بعض الناس 
+
+29
+00:03:56,980 --> 00:04:00,180
+تانية يقول لك لأ تترحل لازم على العماد ومن 
+
+30
+00:04:00,180 --> 00:04:03,860
+العماد يعملوا النورج ومن الورج يهو على القبول على 
+
+31
+00:04:03,860 --> 00:04:05,460
+الشغل الأكاديمي والشغل الأكاديمي يروحوا على
+
+32
+00:04:05,460 --> 00:04:09,500
+القبول والتجديد طبعا على حسب كل واحد أي رأيه 
+
+33
+00:04:09,500 --> 00:04:14,760
+طيب الآن ما هو الهدف من اللامركزية؟ ما هو الهدف
+
+34
+00:04:14,760 --> 00:04:21,860
+عبارة أخرى ما هو الهدف من اللامركزية تمام؟ تهدف أو 
+
+35
+00:04:21,860 --> 00:04:26,260
+الهدف إن الهدف الأساس من اللامركزية إن الهدف
+
+36
+00:04:26,260 --> 00:04:34,320
+الأساس من اللامركزية إن الهدف الأساس من تطبيق 
+
+37
+00:04:34,320 --> 00:04:38,840
+اللامركزية هو زيادة الكفاءة التشغيلية هو زيادة 
+
+38
+00:04:38,840 --> 00:04:46,100
+الكفاءة التشغيلية وتحسينها لدى الأقسام المختلفة
+
+39
+00:04:46,100 --> 00:04:53,610
+لدى الأقسام المختلفة والعمل على تحقيق أهداف المنشأة 
+
+40
+00:04:53,610 --> 00:05:00,050
+العامة والعمل على تحقيق أهداف المنشأة العامة 
+
+41
+00:05:00,050 --> 00:05:03,530
+وزيادة الربحية 
+
+42
+00:05:07,530 --> 00:05:12,010
+طيب، بعد الحديث عن اللي هو تعريف اللامركزية 
+
+43
+00:05:12,010 --> 00:05:17,830
+واختلاف من مؤسسة إلى أخرى وما هو الفائدة من تطبيق 
+
+44
+00:05:17,830 --> 00:05:21,430
+اللامركزية اللي هي كما قلنا زيادة الكفاءة 
+
+45
+00:05:21,430 --> 00:05:25,070
+التشغيلية وتحسين الأداء مما ينعكس في النهاية على 
+
+46
+00:05:25,070 --> 00:05:30,590
+هي زيادة .. زيادة الربحية طيب، مزايا اللامركزية 
+
+47
+00:05:30,590 --> 00:05:37,270
+مزايا اللامركزية advantages مزايا اللامركزية 
+
+48
+00:05:48,200 --> 00:05:56,420
+مزايا اللامركزية advantages decentralization تمام
+
+49
+00:05:56,420 --> 00:05:59,660
+رقم 
+
+50
+00:05:59,660 --> 00:06:06,240
+واحد تمكين الإدارة العليا تمكين الإدارة العليا من 
+
+51
+00:06:06,240 --> 00:06:13,360
+التركيز على الاستراتيجيات طويلة الأجل واحد تمكين
+
+52
+00:06:13,360 --> 00:06:17,940
+الإدارة من الإدارة تمكين الإدارة العليا من التركيز 
+
+53
+00:06:17,940 --> 00:06:27,260
+على استراتيجية طويلة الأجل رقم اثنين توفر 
+
+54
+00:06:27,260 --> 00:06:33,520
+معلومات أكثر تفصيلا لدى مدراء المستوى الأدنى 
+
+55
+00:06:43,630 --> 00:06:48,290
+يعني بيصير الآن زي ما حكينا العمادة لها صلاحيات 
+
+56
+00:06:48,290 --> 00:06:52,910
+العمادة بالصلاحيات هذه بتفوت بعض الصلاحيات لرؤسائها 
+
+57
+00:06:52,910 --> 00:06:58,670
+لرؤسائها أيش؟ لرؤسائها الأقسام وبالتالي هنا رئيس القسم 
+
+58
+00:06:58,670 --> 00:07:00,870
+المعروف والتدريس لديه صلاحيات فبتكون عنده رأي 
+
+59
+00:07:00,870 --> 00:07:07,070
+يتحول لشيء معين اللي هي أكثر وضوحا رقم ثلاثة رقم 
+
+60
+00:07:07,070 --> 00:07:14,380
+ثلاثة تساعد في اكتساب الخبرة اللازمة الخبرة اللازمة 
+
+61
+00:07:14,380 --> 00:07:22,840
+لاتخاذ القرارات لدى مدراء المستوى الأدنى تساعد في 
+
+62
+00:07:22,840 --> 00:07:29,560
+اكتساب الخبرة اللازمة لاتخاذ القرارات لدى مدراء 
+
+63
+00:07:29,560 --> 00:07:39,280
+المستوى الأدنى رقم أربعة زيادة الحافز زيادة الحافز
+
+64
+00:07:39,280 --> 00:07:45,500
+يؤدي إلى زيادة الرضا الوظيفي زيادة الحافز يؤدي إلى 
+
+65
+00:07:45,500 --> 00:07:51,720
+زيادة الرضا الوظيفي ومن ثم تحسين الأداء ومن ثم 
+
+66
+00:07:51,720 --> 00:07:59,120
+تحسين الأداء نقطة أخرى من مزايا اللامركزية من 
+
+67
+00:07:59,120 --> 00:08:07,080
+مزايا اللامركزية مدراء المستوى الأدنى لديهم القدرة 
+
+68
+00:08:07,080 --> 00:08:11,860
+مدراء المستوى الأدنى لديهم القدرة على تلمس 
+
+69
+00:08:11,860 --> 00:08:17,960
+الاحتياجات والاستجابة السريعة للعملاء مدراء 
+
+70
+00:08:17,960 --> 00:08:24,360
+المستوى الأدنى لديهم القدرة على تلمس الاحتياجات 
+
+71
+00:08:24,360 --> 00:08:28,660
+والاستجابة السريعة للعملاء
+
+72
+00:08:29,450 --> 00:08:32,350
+طبعا يعني زي ما يكون الآن اللي هو عندنا في 
+
+73
+00:08:32,350 --> 00:08:37,230
+الكليات رئيس القسم عندما يذهب إليه الطالب يكون 
+
+74
+00:08:37,230 --> 00:08:43,010
+لديه المعرفة في أي مادة ستعدل وأي خطة أي خطة وإيش 
+
+75
+00:08:43,010 --> 00:08:46,370
+ممكن مواد بديلة إيش ممكن كده إيش ممكن كده في طالب 
+
+76
+00:08:46,370 --> 00:08:49,630
+اللي إذا ذهب إلى العمادة لا يستطيع الاستفادة أو 
+
+77
+00:08:49,630 --> 00:08:52,170
+الاستفادة على الإطلاق النقطة الأخيرة 
+
+78
+00:08:56,010 --> 00:09:08,410
+المساعدة في تنمية قدرات المدراء في المنشأة وفرز 
+
+79
+00:09:08,410 --> 00:09:11,110
+المدراء المتميزين
+
+80
+00:09:16,960 --> 00:09:23,080
+في المنشأة وفرز المدراء المتميزين عن غيرهم طبعا 
+
+81
+00:09:23,080 --> 00:09:27,240
+من خلال تفويض الصلاحيات تحصي المؤسسة أن هناك اللي 
+
+82
+00:09:27,240 --> 00:09:31,880
+هو تتوفر وسيلة اللي هي الإدارة اللي أعلى من هذه 
+
+83
+00:09:31,880 --> 00:09:36,080
+المستويات الدنيا أن تفرز المدراء الناجحين وذات 
+
+84
+00:09:36,080 --> 00:09:42,520
+الكفاءة وذات الكفاءة واستخدامهم في مناصب أخرى هذا 
+
+85
+00:09:42,520 --> 00:09:47,670
+بالنسبة بالنسبة إيه أيش؟ للمزايا هذا بالنسبة 
+
+86
+00:09:47,670 --> 00:09:53,510
+للمزايا ننتقل الآن إلى عيوب اللامركزية عيوب الـ 
+
+87
+00:09:53,510 --> 00:10:00,550
+لامركزية عيوب اللامركزية this advantage advantage
+
+88
+00:10:00,550 --> 00:10:08,390
+is decentralization
+
+89
+00:10:08,390 --> 00:10:10,810
+تمام؟ 
+
+90
+00:10:13,020 --> 00:10:16,040
+في حد اللي بده يضيف أي أشياء على مزايا اللي لا 
+
+91
+00:10:16,040 --> 00:10:24,200
+مركزية؟ طيب عيوب اللي لا مركزية رقم واحد اتخاذ 
+
+92
+00:10:24,200 --> 00:10:31,220
+القرارات من قبل مدراء المستوى الأدنى اتخاذ
+
+93
+00:10:31,220 --> 00:10:36,040
+القرارات من قبل المستوى الأدنى من قبل مدراء 
+
+94
+00:10:36,040 --> 00:10:43,680
+المستوى الأدنى يساعد على الاهتمام بالأهداف الخاصة 
+
+95
+00:10:43,680 --> 00:10:52,460
+يساعد على الاهتمام بالأهداف الخاصة الخاصة لهم
+
+96
+00:10:52,460 --> 00:11:03,320
+وإهمال الأهداف العامة للمنشأة رقم 
+
+97
+00:11:03,320 --> 00:11:08,100
+اثنين ضعف 
+
+98
+00:11:08,100 --> 00:11:16,460
+التنسيق ضعف التنسيق بين المدراء المستقلين ضعف 
+
+99
+00:11:16,460 --> 00:11:22,760
+التنسيق بين المدراء المستقلين بمعنى كل شخص عايز 
+
+100
+00:11:22,760 --> 00:11:30,520
+يحقق أهدافه الخاصة النقطة الثالثة تعارض أهداف 
+
+101
+00:11:30,520 --> 00:11:40,940
+مدراء المستوى الأدنى مع أهداف المنشأة تعارض أهداف 
+
+102
+00:11:42,670 --> 00:11:48,090
+المستوى الأدنى مع أهداف المنشأة وهذا ينعكس سلبا 
+
+103
+00:11:48,090 --> 00:11:57,130
+على أداء المؤسسة أو المنشأة ككل النقطة 
+
+104
+00:11:57,130 --> 00:12:02,910
+الرابعة والأخيرة ارتفاع تكاليف جمع المعلومات 
+
+105
+00:12:02,910 --> 00:12:07,890
+الخاصة ارتفاع تكاليف جمع المعلومات الخاصة
+
+106
+00:12:10,060 --> 00:12:15,480
+بتقييم الأداء والرقابة 
+
+107
+00:12:15,480 --> 00:12:19,660
+على الأقسام المختلفة 
+
+108
+00:12:19,660 --> 00:12:27,800
+في المنشأة نأتي الآن بعد ذكر تعريف محاسبة اللامركزية 
+
+109
+00:12:27,800 --> 00:12:34,820
+وأهميتها ودورها ومزاياها وعيوبها إلى محاسبة 
+
+110
+00:12:36,120 --> 00:12:44,520
+المسئولية إلى محاسبة المسئولية كما قلنا عنها سابقا 
+
+111
+00:12:44,520 --> 00:12:51,640
+responsibility accounting محاسبة المسئولية ماذا
+
+112
+00:12:51,640 --> 00:12:57,720
+يقصد بمحاسبة المسئولية ماذا يقصد بمحاسبة المسئولية 
+
+113
+00:12:57,720 --> 00:13:07,850
+يقصد بمحاسبة المسئولية أن أداء كل مدير أن أداء كل 
+
+114
+00:13:07,850 --> 00:13:17,730
+مدير يقاس بحسن إدارته يقاس بحسن إدارته لتلك 
+
+115
+00:13:17,730 --> 00:13:26,910
+الأنشطة لتلك الأنشطة التي تقع ضمن مسئوليته ورقابته 
+
+116
+00:13:26,910 --> 00:13:33,290
+المباشرة ضمن مسئوليته ورقابته المباشرة 
+
+117
+00:13:36,280 --> 00:13:43,500
+عبارة جديدة تعتبر محاسبة المسئولية إحدى الأدوات 
+
+118
+00:13:43,500 --> 00:13:52,800
+المهمة إحدى الأدوات المهمة التي تسهل عملية هي إحدى 
+
+119
+00:13:52,800 --> 00:13:59,360
+الأدوات المهمة التي تسهل عملية تفويض السلطة تفويض 
+
+120
+00:13:59,360 --> 00:14:09,540
+السلطة للإدارات المختلفة للإدارات المختلفة عبارة 
+
+121
+00:14:09,540 --> 00:14:16,140
+أخرى تؤدي محاسبة المسئولية إلى ربط النظام المحاسبي 
+
+122
+00:14:16,140 --> 00:14:25,480
+إلى ربط النظام المحاسبي بشخصية المدراء بشخصية 
+
+123
+00:14:25,480 --> 00:14:32,530
+المدراء إذا المحاسبة المسئولية تعمل على ربط على ربط 
+
+124
+00:14:32,530 --> 00:14:39,030
+النظام المحاسبي بشخصية المدراء يعني كل شخص يسأل عن 
+
+125
+00:14:39,030 --> 00:14:42,530
+ما يقعد ضمن مسئوليته ومثال على ذلك رئيس قسم 
+
+126
+00:14:42,530 --> 00:14:47,190
+المحاسبة يسأل عن الصلاحيات وعن طلاب قسم المحاسبة 
+
+127
+00:14:47,190 --> 00:14:51,110
+وما يوكل إليهم من مهامه وكذلك رئيس قسم الإدارة 
+
+128
+00:14:51,110 --> 00:14:56,440
+وكذلك رئيس قسم الاقتصاد والعلوم السياسية طبعا اللي 
+
+129
+00:14:56,440 --> 00:15:01,020
+حكيت أنه تؤدي محاسبة المسئولية إلى ربط النظام 
+
+130
+00:15:01,020 --> 00:15:06,020
+المحاسبي بشخصيات المدراء أي ينظر إليها، أي ينظر 
+
+131
+00:15:06,020 --> 00:15:10,380
+إلى التكلفة والإيراد أي ينظر إلى التكلفة والإيراد
+
+132
+00:15:10,380 --> 00:15:17,360
+من وجهة نظر الشخص المسئول أي ينظر إلى التكلفة 
+
+133
+00:15:17,360 --> 00:15:23,620
+والإيراد من وجهة نظر الشخص المسئول عن رقابته، عن 
+
+134
+00:15:23,620 --> 00:15:30,200
+رقابتها وليس من وجهة نظر المنشأة وليس من وجهة نظر
+
+135
+00:15:30,200 --> 00:15:36,460
+المنشأة إذا الشخص هنا المسئول وليس وليس أيش وليس 
+
+136
+00:15:36,460 --> 00:15:47,280
+المنشأة طيب ننتقل إلى أيضا 
+
+137
+00:15:47,280 --> 00:15:55,010
+نتحدث المزيد عن محاسبة المسئولية تساهم محاسبة 
+
+138
+00:15:55,010 --> 00:16:01,790
+المسئولية في تعزيز مفهوم الإدارة بالأهداف مفهوم 
+
+139
+00:16:01,790 --> 00:16:07,570
+الإدارة الإدارة 
+
+140
+00:16:07,570 --> 00:16:18,570
+بالأهداف Management by 
+
+141
+00:16:18,570 --> 00:16:20,590
+objective
+
+142
+00:16:30,770 --> 00:16:41,230
+وأيضا مفهوم الإدارة بالاستثناء management by 
+
+143
+00:16:41,230 --> 00:16:45,090
+exception
+
+144
+00:16:54,540 --> 00:16:58,640
+طيب، إذن محاسبة المسئولية تساهم في تعزيز مفهوم 
+
+145
+00:16:58,640 --> 00:17:05,420
+الإدارة بالاستثناء والإدارة بالأهداف طيب، ما لديكم 
+
+146
+00:17:05,420 --> 00:17:13,600
+أي سؤال أو أي مداخلة؟ ننتقل .. فضل، هل تتحدث؟ الآن
+
+147
+00:17:13,600 --> 00:17:22,300
+ننتقل إلى الخطوات اللازمة الخطوات اللازمة لضمان 
+
+148
+00:17:22,300 --> 00:17:32,440
+نجاح الخطوات اللازمة لضمان نجاح وفاعلية 
+
+149
+00:17:32,440 --> 00:17:39,760
+محاسبة المسئولية خطوات 
+
+150
+00:17:39,760 --> 00:17:44,480
+اللازمة لضمان الخطوات 
+
+151
+00:17:44,480 --> 00:17:52,230
+اللازمة لضمان نجاح وفاعلية محاسبة المسئولية واحد 
+
+152
+00:17:52,230 --> 00:17:57,870
+وضع هيكل تنظيمي واضح للمؤسسة وضع هيكل تنظيمي واضح 
+
+153
+00:17:57,870 --> 00:18:05,250
+وشامل للمنشأة وضع هيكل تنظيمي واضح للمنشأة اثنين 
+
+154
+00:18:05,250 --> 00:18:17,830
+ضرورة ووضع معايير محددة وواضحة لكيفية تقييم أداء 
+
+155
+00:18:17,830 --> 00:18:24,510
+أقسام المنشأة أداء أقسام المنشأة ضرورة وضع معيار
+
+156
+00:18:24,510 --> 00:18:32,970
+محددة وواضحة لكيفية تقييم أداء أقسام المنشأة النقطة 
+
+157
+00:18:32,970 --> 00:18:40,930
+الثالثة أن تكون أسس وإجراءات أن تكون أسس وإجراءات 
+
+158
+00:18:40,930 --> 00:18:45,790
+التقييم سهلة ومفهومة
+
+159
+00:18:46,940 --> 00:18:54,220
+وسريعة من قبل المدراء أن تكون أسس وإجراءات التقييم 
+
+160
+00:18:54,220 --> 00:19:03,380
+سهلة ومفهومة وسريعة من قبل المدراء النقطة 
+
+161
+00:19:03,380 --> 00:19:09,480
+الرابعة والأخيرة أن تتضمن عملية التقييم البنود 
+
+162
+00:19:09,480 --> 00:19:15,530
+والأعمال أن تتضمن أن تتضمن عملية التقييم البنود 
+
+163
+00:19:15,530 --> 00:19:25,910
+والأعمال التي تخضع التي تخضع لرقابة وسلطة القسم 
+
+164
+00:19:25,910 --> 00:19:36,830
+المعنى المنوي تقييمه القسم المعني المنوي تقييمه
+
+165
+00:19:36,830 --> 00:19:42,980
+إذا هذه الإجراءات تساعد وتكلل عملية التقييم 
+
+166
+00:19:42,980 --> 00:19:50,620
+بالنجاح نأتي الآن إلى مراكز المسئولية نأتي الآن 
+
+167
+00:19:50,620 --> 00:19:56,520
+إلى في ضمن اللامركزية لابد أن يكون هناك مراكز 
+
+168
+00:19:56,520 --> 00:20:02,200
+مسئولية مراكز المسئولية 
+
+169
+00:20:14,070 --> 00:20:19,950
+responsibility اللي هو الـ centers مراكز
+
+170
+00:20:19,950 --> 00:20:29,350
+المسئولية مراكز المسئولية تمام؟ 
+
+171
+00:20:29,350 --> 00:20:38,690
+إذا 
+
+172
+00:20:38,690 --> 00:20:44,040
+مراكز نتحدث الآن عن المراكز المسئولية مراكز 
+
+173
+00:20:44,040 --> 00:20:53,180
+المسئولية تنقسم في المنشآت إلى ثلاث مراكز مراكز 
+
+174
+00:20:53,180 --> 00:20:57,160
+التكلفة 
+
+175
+00:20:57,160 --> 00:21:03,540
+مراكز الربحية
+
+176
+00:21:03,540 --> 00:21:06,920
+ومراكز 
+
+177
+00:21:06,920 --> 00:21:08,020
+الاستثمار
+
+178
+00:21:15,580 --> 00:21:19,900
+رقم واحد مراكز 
+
+179
+00:21:19,900 --> 00:21:38,060
+التكلفة cost centers مراكز 
+
+180
+00:21:38,060 --> 00:21:41,98
+
+216
+00:26:36,290 --> 00:26:43,570
+طيب نأتي الآن إلى اللا مركزية والتقرير القطاعي
+
+217
+00:26:43,570 --> 00:26:58,110
+اللا مركزية والتقرير القطاعي اللا مركزية والتقرير 
+
+218
+00:26:58,110 --> 00:27:00,650
+القطاعي
+
+219
+00:27:03,610 --> 00:27:07,650
+طبعاً اللي هي المركزية قلنا الـ decentralization
+
+220
+00:27:07,650 --> 00:27:15,850
+and  التقرير
+
+221
+00:27:15,850 --> 00:27:25,370
+القطاعي اللي هو segment report
+
+222
+00:27:25,370 --> 00:27:30,430
+تقرير 
+
+223
+00:27:30,430 --> 00:27:31,650
+القطاعي
+
+224
+00:27:40,460 --> 00:27:44,020
+تعريف القطاع segment
+
+225
+00:27:57,930 --> 00:28:08,650
+طيب تعريف القطاع هو الجزء أو النشاط الذي يتولى 
+
+226
+00:28:08,650 --> 00:28:17,190
+المدير إدارته تعريف القطاع هو الجزء أو النشاط الذي 
+
+227
+00:28:17,190 --> 00:28:27,190
+يتولى المدير إدارته يتولى المدير إدارته إذا 
+
+228
+00:28:29,130 --> 00:28:32,870
+القطاع هو الجزء أو النشاط الذي يتولى المدير إدارته
+
+229
+00:28:56,280 --> 00:29:04,020
+segment margin هامش القطاع يعد هامش القطاع يعد هامش
+
+230
+00:29:04,020 --> 00:29:13,860
+القطاع أفضل معيار أفضل معيار أفضل معيار للحكم على 
+
+231
+00:29:13,860 --> 00:29:21,000
+مقدرة القطاع للحكم على مقدرة القطاع على تحقيق 
+
+232
+00:29:21,000 --> 00:29:28,590
+الربحية على تحقيق الربحية في الأجل الطويل في الأجل
+
+233
+00:29:28,590 --> 00:29:34,090
+الطويل طب ليش؟ لأنه يغطي جميع التكاليف لأنه يغطي 
+
+234
+00:29:34,090 --> 00:29:40,090
+إيش؟ جميع التكاليف إذا يعد هامش القطاع أفضل معيار 
+
+235
+00:29:40,090 --> 00:29:44,950
+للحكم على مقدرة القطاع على تحقيق الربحية في الأجل 
+
+236
+00:29:44,950 --> 00:29:52,370
+الطويل لأنه يغطي إيش؟ جميع التكاليف لأنه يغطي جميع 
+
+237
+00:29:52,370 --> 00:30:00,220
+التكاليف طيب الآن هامش القطاع كيف نطلعه؟ كيف 
+
+238
+00:30:00,220 --> 00:30:03,780
+نحسبه؟ الآن فكر معايا عندما تحدثنا عن نقطة 
+
+239
+00:30:03,780 --> 00:30:15,580
+التعادل هامش المساهمة يساوي المبيعات ناقص التكاليف 
+
+240
+00:30:15,580 --> 00:30:28,880
+المتغيرة طيب طب الآن هامش مساهمة القطاع يساوي يساوي 
+
+241
+00:30:28,880 --> 00:30:38,320
+المبيعات ناقص التكاليف المتغيرة ناقص التكاليف 
+
+242
+00:30:38,320 --> 00:30:50,200
+الثابتة الممكن الممكن تتبعها الممكن تتبعها للقطاع
+
+243
+00:30:50,200 --> 00:31:02,290
+أو أو يساوي يساوي هامش المساهمة 
+
+244
+00:31:02,290 --> 00:31:11,530
+ناقص التكاليف الثابتة الممكن تتبعها والآن سوف
+
+245
+00:31:11,530 --> 00:31:19,250
+أوضحها عندما أضرب اللي هو يا  مثال مثال
+
+246
+00:31:28,040 --> 00:31:33,300
+توفرت لديك البيانات التالية توفرت لديك البيانات 
+
+247
+00:31:33,300 --> 00:31:43,680
+التالية المبيعات خمسة وعشرون ألف دينار التكلفة أو
+
+248
+00:31:43,680 --> 00:31:55,460
+التكاليف المتغيرة خمسة عشر ألف دينار تكاليف ثابتة 
+
+249
+00:31:56,980 --> 00:32:08,900
+ممكن تتبع اللي هي ثلاث آلاف دينار المطلوب المطلوب
+
+250
+00:32:08,900 --> 00:32:12,060
+المطلوب
+
+251
+00:32:12,060 --> 00:32:15,520
+حساب
+
+252
+00:32:15,520 --> 00:32:20,620
+هامش مساهمة القطاع مستخدما
+
+253
+00:32:22,670 --> 00:32:32,270
+قائمة الدخل مستخدما قائمة الدخل طيب
+
+254
+00:32:32,270 --> 00:32:46,310
+الآن الحل الآن الحل الآن هذه قائمة هنا الحل قائمة
+
+255
+00:32:46,310 --> 00:32:51,190
+الدخل المذيعات
+
+256
+00:32:52,450 --> 00:33:00,770
+خمسة وعشرون ألف ناقص التكاليف التكاليف 
+
+257
+00:33:00,770 --> 00:33:11,630
+المتغيرة وهي خمسة عشر ألف إذا يكون لدينا عشرة آلاف
+
+258
+00:33:11,630 --> 00:33:21,750
+هامش المساهمة عشرة آلاف هامش المساهمة طبعا يا شباب
+
+259
+00:33:21,750 --> 00:33:30,510
+عند التكاليف الثابتة .. التكاليف الثابتة في ممكن 
+
+260
+00:33:30,510 --> 00:33:46,930
+تتبع للقطاع وفي إيش عامة لا يمكن إيش تتبع يعني
+
+261
+00:33:46,930 --> 00:33:52,990
+التكاليف الثابتة هتنقسم إلى شقين، شق يرتبط ارتباط 
+
+262
+00:33:52,990 --> 00:33:55,270
+الوثيق بالقسم 
+
+263
+00:33:57,710 --> 00:34:04,970
+وفي تكاليف لا يمكن ربطها بالقسم الآن نصل إلى هامش
+
+264
+00:34:04,970 --> 00:34:10,390
+مساهمة القطاع بنطرح التكاليف الممكن ربطها بالقسم 
+
+265
+00:34:10,390 --> 00:34:16,610
+يعني مثلا إن جهزت تعبير نقول راتب اللي هو السكرتير 
+
+266
+00:34:16,610 --> 00:34:22,270
+أو راتب مثلا راتب رئيس الجسم محاسب نربطه في الجسم
+
+267
+00:34:22,920 --> 00:34:26,160
+راتب سكرتير جسم المحاسبة من راتب جسم المحاسبة لكن 
+
+268
+00:34:26,160 --> 00:34:30,640
+إذا فيها تكاليفها طبعا كانت طلاب جلال اكتار ماهو 
+
+269
+00:34:30,640 --> 00:34:42,760
+مشكلة طيب الآن نطرح برضه تكاليف ثابتة ممكن تتبعها
+
+270
+00:34:42,760 --> 00:34:46,040
+تكاليف 
+
+271
+00:34:46,040 --> 00:34:54,230
+ثابتة ممكن تتبعها هتكون عندنا إيه؟ ثلاثة آلاف هي ثلاثة 
+
+272
+00:34:54,230 --> 00:34:59,550
+آلاف طيب لما نطرحنا ثلاثة آلاف من العشرة هنصل إلى 
+
+273
+00:34:59,550 --> 00:35:09,610
+سبعة آلاف هذا اللي هو إيه؟ هامش مساهمة إيه؟ القطاع
+
+274
+00:35:09,610 --> 00:35:20,350
+هامش مساهمة القطاع ما لدي أي سؤال ما لدي أي سؤال 
+
+275
+00:35:23,530 --> 00:35:30,510
+طبعاً الحديث باقي بس في ضايق شغلة صغيرة ملاحظة تطلب
+
+276
+00:35:30,510 --> 00:35:36,810
+معيار المحاسبة الدولية تطلب معيار المحاسبة الدولية
+
+277
+00:35:36,810 --> 00:35:43,750
+ال
+
+278
+00:35:43,750 --> 00:35:49,030
+IFRS تطلب معيار المحاسبة الدولية اللي هي ال IFRS
+
+279
+00:35:49,030 --> 00:35:56,420
+من الشركات المساهمة المدرجة من الشركات المساهمة
+
+280
+00:35:56,420 --> 00:36:03,440
+المدرجة في الأسواق المالية في الأسواق المالية أن
+
+281
+00:36:03,440 --> 00:36:10,080
+يتضمن تقريرها أن يتضمن تقريرها السنوي على بيانات 
+
+282
+00:36:10,080 --> 00:36:15,680
+مالية على بيانات مالية قطاعية على بيانات مالية
+
+283
+00:36:15,680 --> 00:36:22,860
+قطاعية ما لديها أي سؤال؟ أكون بذلك وصلت إلى نهاية
+
+284
+00:36:22,860 --> 00:36:24,440
+محاضرات اليوم
diff --git a/PL9fwy3NUQKwboNQTWPePHoN8dlQDul_Y4/9jCqX9t1Xgk_raw.json b/PL9fwy3NUQKwboNQTWPePHoN8dlQDul_Y4/9jCqX9t1Xgk_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..166df88fe33b1dd98f49005dc30bc9b76e35897f
--- /dev/null
+++ b/PL9fwy3NUQKwboNQTWPePHoN8dlQDul_Y4/9jCqX9t1Xgk_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 4678, "start": 20.42, "end": 46.78, "text": "عزاء الطلبة نكمل حديثنا عن نقطة التعادل تحدثنا سابقا كما قلت عن نقطة التعادل في حالة إنتاج منتج واحد بينما اليوم سوف نقوم بدراسة نقطة التعادل في حالة تعدد المنتجات", "tokens": [3615, 11622, 16606, 41950, 46152, 3660, 8717, 24793, 1211, 11331, 16254, 12984, 8315, 18871, 8717, 47432, 3660, 16712, 3615, 18513, 1211, 6055, 24401, 12984, 8315, 8608, 16758, 4587, 995, 9122, 15042, 12174, 1211, 2655, 18871, 8717, 47432, 3660, 16712, 3615, 18513, 1211, 8978, 11331, 6027, 3660, 11933, 29399, 26108, 9154, 2655, 7435, 36764, 24401, 49374, 15042, 45595, 20498, 8608, 38688, 8717, 4587, 20498, 47525, 23557, 3794, 3660, 8717, 47432, 3660, 16712, 3615, 18513, 1211, 8978, 11331, 6027, 3660, 6055, 22488, 3215, 9673, 29399, 7435, 9307], "avg_logprob": -0.07421875155942384, "compression_ratio": 1.9932885906040267, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 20.42, "end": 20.92, "word": "عزاء", "probability": 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نطبق هذه الأمور مثال توفرت لديك البيانات التالية توفرت لديك البيانات التالية", "tokens": [1829, 39237, 6225, 42213, 29538, 28239, 3794, 46007, 2423, 7649, 8717, 16572, 3215, 16472, 8717, 9566, 3555, 4587, 29538, 16247, 2304, 13063, 50113, 6027, 33427, 5172, 43500, 5296, 16254, 4117, 2423, 21292, 7649, 9307, 16712, 6027, 10632, 33427, 5172, 43500, 5296, 16254, 4117, 2423, 21292, 7649, 9307, 16712, 6027, 10632], "avg_logprob": -0.12630208158025555, "compression_ratio": 1.8679245283018868, "no_speech_prob": 3.5762786865234375e-07, "words": [{"start": 219.46, "end": 220.06, "word": "يتم", "probability": 0.6610107421875}, {"start": 220.06, "end": 221.4, "word": " عمل", "probability": 0.977294921875}, {"start": 221.4, "end": 222.22, "word": " هذه", "probability": 0.951171875}, {"start": 222.22, "end": 222.72, "word": " النسمة", "probability": 0.5972493489583334}, {"start": 222.72, "end": 224.28, "word": " الان", "probability": 0.6278076171875}, {"start": 224.28, "end": 225.78, "word": " 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diff --git a/PL9fwy3NUQKwboNQTWPePHoN8dlQDul_Y4/ByPoJ-Z7Bnk_raw.json b/PL9fwy3NUQKwboNQTWPePHoN8dlQDul_Y4/ByPoJ-Z7Bnk_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..6800cbf6cee27b8d1ea946a07accb0d8be635f40
--- /dev/null
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@@ -0,0 +1 @@
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"end": 70.61, "word": " هي", "probability": 0.87841796875}, {"start": 70.61, "end": 71.37, "word": " عصب", "probability": 0.9793294270833334}, {"start": 71.37, "end": 72.79, "word": " الوظيفة", "probability": 0.9916015625}, {"start": 72.79, "end": 73.97, "word": " الإدارية", "probability": 0.983154296875}, {"start": 73.97, "end": 74.63, "word": " هي", "probability": 0.1844482421875}, {"start": 74.63, "end": 75.23, "word": " عصب", "probability": 0.9973958333333334}, {"start": 75.23, "end": 76.59, "word": " الوظيفة", "probability": 0.99443359375}, {"start": 76.59, "end": 77.71, "word": " الإدارية", "probability": 0.9949951171875}, {"start": 77.71, "end": 78.73, "word": " وهناك", "probability": 0.8595377604166666}, {"start": 78.73, "end": 79.55, "word": " فيه", "probability": 0.882568359375}, {"start": 79.55, "end": 80.29, "word": " قرارات", "probability": 0.991455078125}, {"start": 80.29, "end": 81.19, "word": " قصيرة", "probability": 0.9969075520833334}, {"start": 81.19, "end": 81.95, "word": " الأجل", "probability": 0.9659830729166666}, {"start": 81.95, "end": 83.51, "word": " وقرارات", "probability": 0.9345703125}, {"start": 83.51, "end": 84.69, "word": " طويلة", "probability": 0.9730224609375}, {"start": 84.69, "end": 85.81, "word": " الأجل", "probability": 0.9913736979166666}], "temperature": 1.0}, {"id": 4, "seek": 11674, "start": 87.88, "end": 116.74, "text": "قصيرة الأجل تتعلق بالعمل اليومي للشركة بينما القرارات طويلة الأجل تكون متعلقة بعمليات التمويلية مثلا واستراتيجية الشركة على المدى الطويل أيضا نذكر نذكر", "tokens": [4587, 9381, 48923, 16247, 7435, 1211, 6055, 2655, 30241, 4587, 20666, 25957, 1211, 45595, 20498, 1829, 24976, 8592, 31747, 3660, 49374, 15042, 25062, 2288, 9640, 9307, 23032, 2407, 26895, 3660, 16247, 7435, 1211, 6055, 30544, 44650, 30241, 28671, 4724, 25957, 20292, 9307, 16712, 2304, 2407, 26895, 10632, 50113, 15040, 36764, 14851, 2288, 9307, 1829, 7435, 10632, 25124, 31747, 3660, 15844, 9673, 3215, 7578, 41950, 2407, 26895, 36632, 11242, 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99.2, "end": 100.02, "word": " تكون", "probability": 0.952392578125}, {"start": 100.02, "end": 101.1, "word": " متعلقة", "probability": 0.9879557291666666}, {"start": 101.1, "end": 104.36, "word": " بعمليات", "probability": 0.9537353515625}, {"start": 104.36, "end": 105.68, "word": " التمويلية", "probability": 0.96328125}, {"start": 105.68, "end": 106.78, "word": " مثلا", "probability": 0.915771484375}, {"start": 106.78, "end": 108.68, "word": " واستراتيجية", "probability": 0.8688267299107143}, {"start": 108.68, "end": 110.1, "word": " الشركة", "probability": 0.9969075520833334}, {"start": 110.1, "end": 110.58, "word": " على", "probability": 0.9619140625}, {"start": 110.58, "end": 111.3, "word": " المدى", "probability": 0.9767252604166666}, {"start": 111.3, "end": 112.24, "word": " الطويل", "probability": 0.9747721354166666}, {"start": 112.24, "end": 113.94, "word": " أيضا", "probability": 0.7970377604166666}, {"start": 113.94, "end": 115.06, "word": " نذكر", "probability": 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122.93, "word": " توفرها", "probability": 0.9019775390625}, {"start": 122.93, "end": 124.03, "word": " المحاسبة", "probability": 0.9683837890625}, {"start": 124.03, "end": 124.71, "word": " الإدارية", "probability": 0.986572265625}, {"start": 124.71, "end": 126.27, "word": " نقول", "probability": 0.82421875}, {"start": 126.27, "end": 127.45, "word": " توفر", "probability": 0.8214518229166666}, {"start": 127.45, "end": 128.59, "word": " المحاسبة", "probability": 0.9947509765625}, {"start": 128.59, "end": 129.89, "word": " الإدارية", "probability": 0.9952392578125}, {"start": 129.89, "end": 131.87, "word": " المعلومات", "probability": 0.9796142578125}, {"start": 131.87, "end": 134.01, "word": " الملائمة", "probability": 0.9698486328125}, {"start": 134.01, "end": 136.57, "word": " لعملية", "probability": 0.9471435546875}], "temperature": 1.0}, {"id": 6, "seek": 16084, "start": 138.76, "end": 160.84, "text": "لعملية اتخاذ القرارات وعندما نقول ان المحاسب الإدارية توفر المعلومات اللازمة نقصد هنا المعلومات المالية وغير المالية المعلومات المالية وغير المالية المعلومات تكون", "tokens": [1211, 25957, 1211, 10632, 1975, 2655, 9778, 45636, 25062, 2288, 9640, 9307, 4032, 3615, 41260, 15042, 8717, 39648, 16472, 9673, 5016, 32277, 3555, 33688, 3215, 9640, 10632, 33427, 5172, 2288, 9673, 30241, 20498, 9307, 13672, 31377, 46007, 8717, 4587, 9381, 3215, 34105, 9673, 30241, 20498, 9307, 9673, 6027, 10632, 4032, 17082, 13546, 9673, 6027, 10632, 9673, 30241, 20498, 9307, 9673, 6027, 10632, 4032, 17082, 13546, 9673, 6027, 10632, 9673, 30241, 20498, 9307, 6055, 30544], "avg_logprob": -0.06723958253860474, "compression_ratio": 2.3230769230769233, "no_speech_prob": 8.809566497802734e-05, "words": [{"start": 138.76, "end": 139.42, "word": "لعملية", "probability": 0.848876953125}, {"start": 139.42, "end": 140.22, "word": " اتخاذ", "probability": 0.971435546875}, {"start": 140.22, "end": 141.58, "word": " القرارات", "probability": 0.9888916015625}, {"start": 141.58, "end": 142.44, "word": " وعندما", "probability": 0.888916015625}, {"start": 142.44, "end": 142.84, "word": " نقول", "probability": 0.985595703125}, {"start": 142.84, "end": 143.02, "word": " ان", "probability": 0.72216796875}, {"start": 143.02, "end": 143.6, "word": " المحاسب", "probability": 0.918212890625}, {"start": 143.6, "end": 144.12, "word": " الإدارية", "probability": 0.8814697265625}, {"start": 144.12, "end": 144.66, "word": " توفر", "probability": 0.9069010416666666}, {"start": 144.66, "end": 145.6, "word": " المعلومات", "probability": 0.9913330078125}, {"start": 145.6, "end": 146.42, "word": " اللازمة", "probability": 0.9972330729166666}, {"start": 146.42, "end": 147.52, "word": " نقصد", "probability": 0.972900390625}, {"start": 147.52, "end": 148.04, "word": " هنا", "probability": 0.96240234375}, {"start": 148.04, "end": 149.88, "word": " المعلومات", "probability": 0.984130859375}, {"start": 149.88, "end": 151.7, "word": " المالية", "probability": 0.98974609375}, {"start": 151.7, "end": 152.94, "word": " وغير", "probability": 0.93505859375}, {"start": 152.94, "end": 154.32, "word": " المالية", "probability": 0.994140625}, {"start": 154.32, "end": 155.54, "word": " المعلومات", "probability": 0.9678955078125}, {"start": 155.54, "end": 156.3, "word": " المالية", "probability": 0.9112955729166666}, {"start": 156.3, "end": 157.36, "word": " وغير", "probability": 0.9786783854166666}, {"start": 157.36, "end": 158.34, "word": " المالية", "probability": 0.9959309895833334}, {"start": 158.34, "end": 159.9, "word": " المعلومات", "probability": 0.8916015625}, {"start": 159.9, "end": 160.84, "word": " تكون", "probability": 0.97607421875}], "temperature": 1.0}, {"id": 7, "seek": 17490, "start": 161.64, "end": 174.9, "text": "متعلقة بتكلفة الوحدة و هي رقمية و معلومات أخرى عن الحجم و الإنتاج مستقبلا و حاليا و المواد و عدد الموظفين و كفاءة الموظفين", "tokens": [2304, 2655, 30241, 28671, 39894, 28820, 5172, 3660, 2423, 2407, 24401, 3660, 4032, 39896, 12602, 4587, 2304, 10632, 4032, 20449, 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167.14, "word": " معلومات", "probability": 0.9151611328125}, {"start": 167.14, "end": 167.78, "word": " أخرى", "probability": 0.9078776041666666}, {"start": 167.78, "end": 168.12, "word": " عن", "probability": 0.9853515625}, {"start": 168.12, "end": 168.74, "word": " الحجم", "probability": 0.9923502604166666}, {"start": 168.74, "end": 168.92, "word": " و", "probability": 0.71630859375}, {"start": 168.92, "end": 170.04, "word": " الإنتاج", "probability": 0.94189453125}, {"start": 170.04, "end": 170.64, "word": " مستقبلا", "probability": 0.90380859375}, {"start": 170.64, "end": 170.74, "word": " و", "probability": 0.83447265625}, {"start": 170.74, "end": 171.1, "word": " حاليا", "probability": 0.9501953125}, {"start": 171.1, "end": 171.2, "word": " و", "probability": 0.88623046875}, {"start": 171.2, "end": 171.72, "word": " المواد", "probability": 0.9591471354166666}, {"start": 171.72, "end": 172.24, "word": " و", "probability": 0.609375}, {"start": 172.24, "end": 172.86, "word": " عدد", "probability": 0.7268880208333334}, {"start": 172.86, "end": 173.58, "word": " الموظفين", "probability": 0.97744140625}, {"start": 173.58, "end": 173.7, "word": " و", "probability": 0.9560546875}, {"start": 173.7, "end": 174.14, "word": " كفاءة", "probability": 0.907470703125}, {"start": 174.14, "end": 174.9, "word": " الموظفين", "probability": 0.993359375}], "temperature": 1.0}, {"id": 8, "seek": 18756, "start": 178.18, "end": 187.56, "text": "ننتقل الآن إلى العنوان الأول في هذا الفصل قرار التصنيع الداخلي أو الشراء", "tokens": [1863, 29399, 4587, 1211, 6024, 48506, 30731, 18863, 1863, 2407, 7649, 16247, 12610, 8978, 23758, 27188, 36520, 12174, 2288, 9640, 16712, 9381, 22653, 3615, 32748, 47283, 20292, 34051, 25124, 2288, 16606], "avg_logprob": -0.17626953637227416, "compression_ratio": 1.4193548387096775, "no_speech_prob": 3.2782554626464844e-06, "words": [{"start": 178.18, "end": 178.88, "word": "ننتقل", "probability": 0.8299560546875}, {"start": 178.88, "end": 179.42, "word": " 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195.17, "end": 224.89, "text": "the make or buy decision الان عملية قرار التصنيع الداخلي او الشراء قرار قرار التصنيع الداخلي او الشراء او الشراء", "tokens": [3322, 652, 420, 2256, 3537, 2423, 7649, 6225, 42213, 10632, 12174, 2288, 9640, 16712, 9381, 22653, 3615, 32748, 47283, 20292, 1975, 2407, 25124, 2288, 16606, 12174, 2288, 9640, 12174, 2288, 9640, 16712, 9381, 22653, 3615, 32748, 47283, 20292, 1975, 2407, 25124, 2288, 16606, 1975, 2407, 25124, 2288, 16606], "avg_logprob": -0.13823341836734693, "compression_ratio": 1.9473684210526316, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 195.17, "end": 195.45, "word": "the", "probability": 0.344970703125}, {"start": 195.45, "end": 195.99, "word": " make", "probability": 0.96484375}, {"start": 195.99, "end": 197.03, "word": " or", "probability": 0.9150390625}, {"start": 197.03, "end": 197.91, "word": " buy", "probability": 0.69775390625}, {"start": 197.91, "end": 203.09, "word": " decision", "probability": 0.96435546875}, 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" ام", "probability": 0.806640625}, {"start": 627.86, "end": 629.48, "word": " الشراء", "probability": 0.9143880208333334}], "temperature": 1.0}, {"id": 25, "seek": 65613, "start": 630.75, "end": 656.13, "text": "من الخارج ام الشراء من الخارج اذا هذا المثال مثال رقم واحد الان نأتي الى الحل ونقول هاي التصنيع وهنا هاي الشراء", "tokens": [27842, 33962, 9640, 7435, 1975, 2304, 25124, 2288, 16606, 9154, 33962, 9640, 7435, 1975, 15730, 23758, 9673, 12984, 6027, 50113, 6027, 12602, 4587, 2304, 36764, 24401, 2423, 7649, 8717, 10721, 31371, 2423, 7578, 21542, 1211, 4032, 1863, 39648, 8032, 47302, 16712, 9381, 22653, 3615, 37037, 8315, 8032, 47302, 25124, 2288, 16606], "avg_logprob": -0.1675180302789578, "compression_ratio": 1.763157894736842, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 630.75, "end": 631.01, "word": "من", "probability": 0.9267578125}, {"start": 631.01, "end": 631.69, "word": " الخارج", "probability": 0.9977213541666666}, {"start": 631.69, "end": 633.31, "word": 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التمانين تمانين الف", "tokens": [2304, 3555, 33599, 25720, 9673, 14407, 3215, 9673, 3555, 33599, 25720, 9673, 14407, 3215, 9673, 3555, 33599, 25720, 5296, 16254, 8315, 34105, 23032, 3555, 3615, 995, 1975, 8315, 6024, 48506, 4724, 16254, 1975, 5016, 35457, 6055, 4117, 6027, 33911, 16712, 2304, 7649, 9957, 46811, 7649, 9957, 27188], "avg_logprob": -0.22835287110259136, "compression_ratio": 1.846938775510204, "no_speech_prob": 2.86102294921875e-06, "words": [{"start": 683.79, "end": 684.59, "word": "مباشرة", "probability": 0.77587890625}, {"start": 684.59, "end": 685.77, "word": " المواد", "probability": 0.9025065104166666}, {"start": 685.77, "end": 686.71, "word": " المباشرة", "probability": 0.9927978515625}, {"start": 686.71, "end": 687.89, "word": " المواد", "probability": 0.7603352864583334}, {"start": 687.89, "end": 689.43, "word": " المباشرة", "probability": 0.9927978515625}, {"start": 689.43, "end": 691.53, "word": " لدينا", "probability": 0.9059244791666666}, {"start": 691.53, 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"temperature": 1.0}, {"id": 35, "seek": 88919, "start": 877.99, "end": 889.19, "text": "الان تلاتة عشرين في تمانين الف هتطلع مليون مليون مليون تمانمية واربعين الف", "tokens": [6027, 7649, 6055, 1211, 9307, 3660, 6225, 46309, 9957, 8978, 46811, 7649, 9957, 27188, 8032, 2655, 9566, 1211, 3615, 3714, 20292, 11536, 3714, 20292, 11536, 3714, 20292, 11536, 46811, 7649, 2304, 10632, 4032, 9640, 3555, 3615, 9957, 27188], "avg_logprob": -0.26782853481097096, "compression_ratio": 1.5632183908045978, "no_speech_prob": 7.152557373046875e-07, "words": [{"start": 877.99, "end": 878.65, "word": "الان", "probability": 0.75732421875}, {"start": 878.65, "end": 880.09, "word": " تلاتة", "probability": 0.76080322265625}, {"start": 880.09, "end": 880.49, "word": " عشرين", "probability": 0.8084309895833334}, {"start": 880.49, "end": 880.61, "word": " في", "probability": 0.8671875}, {"start": 880.61, "end": 881.05, "word": " تمانين", "probability": 0.8898111979166666}, {"start": 881.05, "end": 881.47, 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لديه أي سؤال؟", "tokens": [6027, 2655, 9381, 22653, 3615, 13672, 1829, 31439, 8032, 25528, 3714, 10632, 16490, 2304, 3794, 9957, 5551, 46538, 11933, 15730, 8032, 47302, 8608, 3555, 25957, 10632, 4032, 16490, 2304, 3794, 9957, 4032, 34105, 8608, 3555, 25957, 10632, 4032, 16490, 2304, 3794, 9957, 3714, 6027, 5296, 16254, 3224, 36632, 8608, 33604, 6027, 22807, 3714, 6027, 5296, 16254, 3224, 36632, 8608, 33604, 6027, 22807], "avg_logprob": -0.1953124933772617, "compression_ratio": 1.8363636363636364, "no_speech_prob": 0.0, "words": [{"start": 2155.66, "end": 2156.86, "word": "التصنيع", "probability": 0.94736328125}, {"start": 2156.86, "end": 2157.8, "word": " اللي", "probability": 0.718994140625}, {"start": 2157.8, "end": 2157.96, "word": " هو", "probability": 0.87939453125}, {"start": 2157.96, "end": 2158.46, "word": " هيا", "probability": 0.391357421875}, {"start": 2158.46, "end": 2159.72, "word": " مية", "probability": 0.6392822265625}, {"start": 2159.72, "end": 2161.02, "word": " خمسين", "probability": 0.940185546875}, {"start": 2161.02, "end": 2162.12, "word": " ألف", "probability": 0.803466796875}, {"start": 2162.12, "end": 2163.34, "word": " إذا", "probability": 0.531982421875}, {"start": 2163.34, "end": 2165.7, "word": " هاي", "probability": 0.785888671875}, {"start": 2165.7, "end": 2167.14, "word": " سبعمية", "probability": 0.767822265625}, {"start": 2167.14, "end": 2167.28, "word": " و", "probability": 0.99560546875}, {"start": 2167.28, "end": 2167.88, "word": " خمسين", "probability": 0.8916015625}, {"start": 2167.88, "end": 2168.52, "word": " و", "probability": 0.53369140625}, {"start": 2168.52, "end": 2168.84, "word": " هنا", "probability": 0.75732421875}, {"start": 2168.84, "end": 2170.16, "word": " سبعمية", "probability": 0.974365234375}, {"start": 2170.16, "end": 2171.22, "word": " و", "probability": 0.99267578125}, {"start": 2171.22, "end": 2171.9, "word": " خمسين", "probability": 0.97607421875}, {"start": 2171.9, "end": 2176.92, "word": " مال", "probability": 0.7822265625}, {"start": 2176.92, "end": 2177.4, "word": " لديه", "probability": 0.927734375}, {"start": 2177.4, "end": 2178.02, "word": " أي", "probability": 0.78759765625}, {"start": 2178.02, "end": 2178.98, "word": " سؤال؟", "probability": 0.84149169921875}, {"start": 2178.98, "end": 2181.62, "word": " مال", "probability": 0.904052734375}, {"start": 2181.62, "end": 2182.24, "word": " لديه", "probability": 0.9900716145833334}, {"start": 2182.24, "end": 2183.18, "word": " أي", "probability": 0.8740234375}, {"start": 2183.18, "end": 2184.02, "word": " سؤال؟", "probability": 0.98974609375}], "temperature": 1.0}, {"id": 85, "seek": 221371, "start": 2184.62, "end": 2213.72, "text": "في إضافة صغيرة طيب الآن فرضا أنه تم توفير تسعين في المية من تكاليف الموزعة الصناعية الموزعة الآن إيش بدى يكون الوضع؟", "tokens": [41185, 11933, 11242, 31845, 3660, 20328, 17082, 48923, 23032, 1829, 3555, 6024, 48506, 6156, 43042, 995, 14739, 3224, 46811, 33427, 5172, 13546, 6055, 3794, 3615, 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{"start": 2197.64, "end": 2198.56, "word": " توفير", "probability": 0.96044921875}, {"start": 2198.56, "end": 2200.62, "word": " تسعين", "probability": 0.8795166015625}, {"start": 2200.62, "end": 2201.4, "word": " في", "probability": 0.39111328125}, {"start": 2201.4, "end": 2202.02, "word": " المية", "probability": 0.90625}, {"start": 2202.02, "end": 2203.12, "word": " من", "probability": 0.98046875}, {"start": 2203.12, "end": 2204.46, "word": " تكاليف", "probability": 0.8775634765625}, {"start": 2204.46, "end": 2206.92, "word": " الموزعة", "probability": 0.9495849609375}, {"start": 2206.92, "end": 2208.56, "word": " الصناعية", "probability": 0.9735107421875}, {"start": 2208.56, "end": 2210.84, "word": " الموزعة", "probability": 0.995361328125}, {"start": 2210.84, "end": 2212.0, "word": " الآن", "probability": 0.769287109375}, {"start": 2212.0, "end": 2212.54, "word": " إيش", "probability": 0.7967936197916666}, {"start": 2212.54, "end": 2212.66, "word": " بدى", "probability": 0.408203125}, {"start": 2212.66, "end": 2212.86, "word": " يكون", "probability": 0.96630859375}, {"start": 2212.86, "end": 2213.72, "word": " الوضع؟", "probability": 0.84677734375}], "temperature": 1.0}, {"id": 86, "seek": 222907, "start": 2216.19, "end": 2229.07, "text": "يكون الوضع لصالح الشراء يعني .. يعني هتكون هنا هاي سبعمائة وستين وهنا سبعمائة وإيش", "tokens": [1829, 30544, 2423, 2407, 11242, 3615, 5296, 9381, 6027, 5016, 25124, 2288, 16606, 37495, 22653, 4386, 37495, 22653, 8032, 2655, 30544, 34105, 8032, 47302, 8608, 3555, 25957, 16373, 3660, 4032, 14851, 9957, 37037, 8315, 8608, 3555, 25957, 16373, 3660, 4032, 28814, 1829, 8592], "avg_logprob": -0.2835582318631085, "compression_ratio": 1.48, "no_speech_prob": 0.0, "words": [{"start": 2216.19, "end": 2216.65, "word": "يكون", "probability": 0.581298828125}, {"start": 2216.65, "end": 2217.29, "word": " الوضع", "probability": 0.9844970703125}, {"start": 2217.29, "end": 2218.35, "word": " لصالح", "probability": 0.99169921875}, 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لديه أي سؤال؟ طبعا أعزاء الطلبة نأتي إلى نهاية محاضرة اليوم وإلى اللقاء في محاضرة قادمة", "tokens": [15042, 13672, 1829, 5296, 16254, 3224, 36632, 8608, 33604, 6027, 22807, 23032, 3555, 3615, 995, 5551, 3615, 11622, 16606, 41950, 46152, 3660, 8717, 10721, 31371, 30731, 8717, 11296, 10632, 3714, 5016, 46958, 25720, 45595, 20498, 4032, 28814, 23942, 13672, 4587, 16606, 8978, 3714, 5016, 46958, 25720, 12174, 18513, 46007], "avg_logprob": -0.14757812947034835, "compression_ratio": 1.4913793103448276, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2259.95, "end": 2260.19, "word": "ما", "probability": 0.443359375}, {"start": 2260.19, "end": 2260.31, "word": " اللي", "probability": 0.74169921875}, {"start": 2260.31, "end": 2260.65, "word": " لديه", "probability": 0.8640950520833334}, {"start": 2260.65, "end": 2260.79, "word": " أي", "probability": 0.69384765625}, {"start": 2260.79, "end": 2263.39, "word": " سؤال؟", "probability": 0.935302734375}, {"start": 2263.39, "end": 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{"start": 2273.49, "end": 2274.55, "word": " قادمة", "probability": 0.9739583333333334}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2274.742875, "duration_after_vad": 2181.581874999993}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwboNQTWPePHoN8dlQDul_Y4/dj1XyyiSEMk_postprocess.srt b/PL9fwy3NUQKwboNQTWPePHoN8dlQDul_Y4/dj1XyyiSEMk_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..d4a5ca23e8ce2f1fc323548173e6d6c7ae613879
--- /dev/null
+++ b/PL9fwy3NUQKwboNQTWPePHoN8dlQDul_Y4/dj1XyyiSEMk_postprocess.srt
@@ -0,0 +1,1028 @@
+1
+00:00:21,160 --> 00:00:27,620
+أعزائي الطلبة نكمل الحديث عن أسعار التحويل تحدثنا
+
+2
+00:00:27,620 --> 00:00:32,120
+في المحاضرة السابقة عن السعر التفاوضي اليوم نتحدث
+
+3
+00:00:32,120 --> 00:00:43,120
+عن سعر التكلفة اليوم نتحدث عن سعر التكلفة اللي هو
+
+4
+00:00:43,120 --> 00:00:45,860
+ال cost price
+
+5
+00:00:50,710 --> 00:00:59,170
+وفقا لسعر التكلفة يتم
+
+6
+00:00:59,170 --> 00:01:07,370
+تحويل الوحدات المباعة بسعر
+
+7
+00:01:07,370 --> 00:01:12,690
+التكلفة ونقصد بسعر التكلفة هنا أما التكلفة
+
+8
+00:01:12,690 --> 00:01:19,030
+المتغيرة المتغيرة
+
+9
+00:01:20,120 --> 00:01:29,780
+أو التكلفة الكلية التكلفة المتغيرة هي نصيب الوحدة
+
+10
+00:01:29,780 --> 00:01:34,400
+من التكليف المتغير وهذه كما قلنا سابقا العلاقة
+
+11
+00:01:34,400 --> 00:01:37,980
+تكون طردية بينها التكلفة الكلية هي تشمل بشقيها
+
+12
+00:01:37,980 --> 00:01:45,520
+بشقيها متغير زائد IH زائد نصيب نصيب الوحدة
+
+13
+00:01:47,900 --> 00:01:56,380
+التحويل على أساس سعر التكلفة لا
+
+14
+00:01:56,380 --> 00:02:06,320
+يحقق للقسم البائع أي أرباح وفق السعر التكلفة فإن
+
+15
+00:02:06,320 --> 00:02:12,760
+القسم البائع لا يحقق أي أرباح بينما الأرباح تكون
+
+16
+00:02:12,760 --> 00:02:21,620
+للقسم المشتريبينما القسم المشتري و مثلا مثال عنه
+
+17
+00:02:21,620 --> 00:02:28,800
+اللي هو حكينا المطاحن و المخابز و هدول مركزيا
+
+18
+00:02:28,800 --> 00:02:37,140
+استثمار لشركات فلسطين الوطنية الآن لو طرد دقيق
+
+19
+00:02:37,140 --> 00:02:44,940
+مثلا هنا بيكلف فرضا الفدرار تكلفة يحول هنا إلى
+
+20
+00:02:44,940 --> 00:02:51,320
+ماذا؟ بسعر التكلفة يباع له يعني هو بيكلفه ألف و
+
+21
+00:02:51,320 --> 00:02:57,400
+بيبيعه بالألف إذا هامش المساهمة أيه؟ هامش المساهمة
+
+22
+00:02:57,400 --> 00:03:02,560
+بيكون عنده أيه؟ صفر يكون هامش المساهمة أيه؟ صفر
+
+23
+00:03:02,560 --> 00:03:03,700
+طيب
+
+24
+00:03:06,470 --> 00:03:11,830
+الان ايضا سعر التحويل
+
+25
+00:03:11,830 --> 00:03:19,050
+على أساس التكلفة غير قادر على
+
+26
+00:03:19,050 --> 00:03:23,610
+إيجاد حوافز
+
+27
+00:03:23,610 --> 00:03:25,330
+للرقابة على التكليف
+
+28
+00:03:31,140 --> 00:03:37,000
+لأن هو اليوم قسم مطاحن بكلفه ألف كلفة طن ألف و
+
+29
+00:03:37,000 --> 00:03:40,760
+ببيعه بالألف لو حتة كلفة ايش ما يكلفه بدي بيعه
+
+30
+00:03:40,760 --> 00:03:43,460
+وبالتالي بيقولك انا مش مسئول عن التكلفة جليل كتيرة
+
+31
+00:03:43,460 --> 00:03:49,060
+مافيش ليه حوافز وبالتالي مش مشكلة ممكن يزيد تكلفته
+
+32
+00:03:49,060 --> 00:03:52,060
+عن الألف مثلا يزيد ويقولك مافي ناس تانية اللي
+
+33
+00:03:52,060 --> 00:03:56,760
+هتربح وهي تتحمل في هذا الأمر طيب سؤال
+
+34
+00:03:59,620 --> 00:04:05,420
+تتكون شركة فلسطين الصناعية
+
+35
+00:04:05,420 --> 00:04:10,040
+من مركزي استثمار
+
+36
+00:04:10,040 --> 00:04:16,680
+هما
+
+37
+00:04:16,680 --> 00:04:20,240
+المحولات
+
+38
+00:04:20,240 --> 00:04:21,620
+والموتورات
+
+39
+00:04:28,130 --> 00:04:37,530
+واحد قسم المحولات قسم المحولات الطاقة
+
+40
+00:04:37,530 --> 00:04:42,590
+الإنتاجية السنوية له الطاقة الإنتاجية السنوية له
+
+41
+00:04:42,590 --> 00:04:50,910
+خمسين ألف محول خمسين ألف محول والتكلفة
+
+42
+00:04:50,910 --> 00:04:54,530
+المتغيرة للمحول اتناشر دنار
+
+43
+00:04:57,200 --> 00:05:03,100
+وساعة البيع عشرين دولار تكلف المتغير اتناشر دولار
+
+44
+00:05:03,100 --> 00:05:12,160
+وساعة البيع عشرين دولار وتحتاج كل واحدة إلى ساعة
+
+45
+00:05:12,160 --> 00:05:19,880
+عمل مباشرة ساعة عمل مباشرة اتنين قسم الموتورات
+
+46
+00:05:19,880 --> 00:05:24,240
+اتنين قسم الموتورات
+
+47
+00:05:32,230 --> 00:05:43,610
+ابتكر موتور جديد او اخترع موتور جديد يتطلب
+
+48
+00:05:43,610 --> 00:05:53,870
+محولا كهربائيا يختلف عن الذي يقوم بتصنيعه قسم
+
+49
+00:05:53,870 --> 00:05:54,730
+المحولات
+
+50
+00:05:57,920 --> 00:06:09,300
+وهناك بديلين أمام قسم الموتورات هما يعني
+
+51
+00:06:09,300 --> 00:06:15,670
+الآن قسم الموتورات اخترعموتور جديد الموتور الجديد
+
+52
+00:06:15,670 --> 00:06:20,250
+يحتاج إلى محول هذا المحول يختلف عن المحول الذي
+
+53
+00:06:20,250 --> 00:06:25,150
+يصنعه قسم المحولات فامامه بدلين يا اما يوجه جسم
+
+54
+00:06:25,150 --> 00:06:29,570
+المحولات و يصنع له هو او يشتري من الخارج البديل
+
+55
+00:06:29,570 --> 00:06:34,290
+الاول الشراء من الخارج شراء المحول من الخارج
+
+56
+00:06:34,290 --> 00:06:38,710
+البديل الاول شراء المحول من الخارج
+
+57
+00:06:43,060 --> 00:06:49,040
+بسعر خمستاشر دولار لكل
+
+58
+00:06:49,040 --> 00:06:56,980
+محول وعلى أساس شراء خمسين ألف وحدة لخمسين ألف محول
+
+59
+00:06:56,980 --> 00:07:00,200
+هذا
+
+60
+00:07:00,200 --> 00:07:05,400
+أيش البديل الأول البديل الأول شراء من الخارج
+
+61
+00:07:05,400 --> 00:07:10,620
+المحول يشتريه بخمستاشر ألف ويشتري الطاقة بالكامل
+
+62
+00:07:10,620 --> 00:07:16,340
+لخمسين ألف وحدةالبديل التاني البديل التاني تصنيع
+
+63
+00:07:16,340 --> 00:07:22,720
+المحول الجديد من قبل قسم المحولات من قبل قسم
+
+64
+00:07:22,720 --> 00:07:30,680
+المحولات ويستغرق كل الطاقة الإنتاجية ويستغرق كل
+
+65
+00:07:30,680 --> 00:07:38,480
+الطاقة الإنتاجية ويحتاج كل محول يحتاج كل محول إلى
+
+66
+00:07:38,480 --> 00:07:48,130
+ساعةعمل مباشرة وتبلغ تكلفة الوحدة اللي هو المخصوص
+
+67
+00:07:48,130 --> 00:07:59,370
+المحول اللي هو عشر دلانير هذا
+
+68
+00:07:59,370 --> 00:08:05,330
+البديل التاني البديل الأول اللي قلناه يتم الشراء
+
+69
+00:08:05,330 --> 00:08:10,660
+من الخارج بـ15البديل التاني يتم شراءه تصنيعه
+
+70
+00:08:10,660 --> 00:08:15,360
+داخليا له خص نص وياخدوا منه بعشر دولار لكن الان
+
+71
+00:08:15,360 --> 00:08:21,020
+اسمعش نحكي الان يحتاج الموتور الجديد هذه فقرة
+
+72
+00:08:21,020 --> 00:08:26,120
+مستقلة يحتاج الموتور الجديد الى خمسة وعشرين دولار
+
+73
+00:08:26,120 --> 00:08:36,760
+تكاليف متغيرة أخرى سواء صنة داخليا او
+
+74
+00:08:38,520 --> 00:08:46,360
+تم شراءه من الخارج أو تم شراءه من الخارج وفي كلتال
+
+75
+00:08:46,360 --> 00:08:52,740
+حالتين يباع وفي كلتال حالتين يباع بسعر ستين دولار
+
+76
+00:08:52,740 --> 00:08:55,880
+ليه؟
+
+77
+00:08:55,880 --> 00:09:04,960
+بسعر ستين دولار المطلوب هل سيقوم قسم المحولات هل
+
+78
+00:09:04,960 --> 00:09:11,190
+سيقوم قسم المحولاتبالتحول إلى إنتاج المحول الجديد
+
+79
+00:09:11,190 --> 00:09:16,210
+ام
+
+80
+00:09:16,210 --> 00:09:19,270
+لا؟
+
+81
+00:09:19,270 --> 00:09:24,750
+ام لا؟ ايش معناه هذا الكلام؟ معناه هل كل واحد من
+
+82
+00:09:24,750 --> 00:09:29,850
+الأقسام سيكون مستقلا استقلالا و يعمل و يبيع لوحده؟
+
+83
+00:09:30,310 --> 00:09:34,450
+أم القسم المحولات اللى في داخل الشركة يوصلنا لمحول
+
+84
+00:09:34,450 --> 00:09:39,870
+جديد ويحوله ليش إلى قسم المطارات وهو في هذه الحالة
+
+85
+00:09:39,870 --> 00:09:43,990
+يحوله بالتكلفة ولا يحقق أي أربعة نريد أن نشوف ميشي
+
+86
+00:09:43,990 --> 00:09:51,090
+المناسب للشركة إذا البديل الأول البديل البديل
+
+87
+00:09:51,090 --> 00:10:02,830
+الأول الشراء من الخارج خمسين ألف محولخمسين ألف
+
+88
+00:10:02,830 --> 00:10:11,330
+محول طيب الآن البديل الأول أن جسم المحولات ينتج
+
+89
+00:10:11,330 --> 00:10:17,970
+ويبيع للخارج وقسم المطرات يشتري محول من الخارج
+
+90
+00:10:17,970 --> 00:10:22,730
+ويعمل عليه إضافات ويبيع منتجه للخارج يعني كل واحد
+
+91
+00:10:22,730 --> 00:10:29,790
+مستقل استقلالا تم اذا هنا هذه بيان هنا هذا قسم
+
+92
+00:10:31,010 --> 00:10:39,190
+المحولات وهنا قسم المطورات وهنا حيكون عندنا على
+
+93
+00:10:39,190 --> 00:10:46,130
+المستوى الكلي بالتالي هنا هذه المحولات هنا للوحدة
+
+94
+00:10:46,130 --> 00:10:58,130
+هنا للجميع هنا للوحدة هنا للجميع هنا المطورات
+
+95
+00:11:00,870 --> 00:11:07,410
+المجموع الكل الآن كما قلنا هذا البديل الشراء من
+
+96
+00:11:07,410 --> 00:11:09,770
+الخارج والشراء من الخارج يكون كل واحد منهم مستقل
+
+97
+00:11:09,770 --> 00:11:16,090
+استغلال التامة إذا هنا نقول المبيعات المبيعات ساعة
+
+98
+00:11:16,090 --> 00:11:24,610
+بيع الوحدة المحولات ينتج تكلفة الوحدة كم؟ 12 تكلفة
+
+99
+00:11:24,610 --> 00:11:31,920
+متغيرة وبيعها بكم؟بعشرين تمام؟ إذا الآن عشرين في
+
+100
+00:11:31,920 --> 00:11:41,620
+خمسين ألف بإيش؟ بمليون طيب اتناش في خمسين بست مية
+
+101
+00:11:41,620 --> 00:11:53,640
+إذا .. إذا هنا هنا هامش المساهمة هيكون عندنا هنا
+
+102
+00:11:53,640 --> 00:12:02,810
+أربعمائة ألف ديار400 ألف دولار تمام هذا بالنسبة
+
+103
+00:12:02,810 --> 00:12:07,250
+لقسم المحاولات بيصنع لحاله بيبيع لحاله وهي ربحه
+
+104
+00:12:07,250 --> 00:12:12,550
+طيب الان نفس الشيء بالنسبة لقسم المطرات هيعمل بكم
+
+105
+00:12:12,550 --> 00:12:20,350
+يبيع بكم 60 لكن التكاريف المتغيرة هيشتري بكم 40
+
+106
+00:12:20,350 --> 00:12:31,510
+هيشتري ب15 هيشتري ب15هيشتغل 15 وفيه تكليف أخرى
+
+107
+00:12:31,510 --> 00:12:38,170
+متغيرة 25 إذا إجمال التكلفة المتغيرة كام؟ 40 طيب
+
+108
+00:12:38,170 --> 00:12:47,210
+ال 60 في 50 ألف تلاتة مليون تلاتة مليون هاي تلاتة
+
+109
+00:12:47,210 --> 00:12:56,870
+مليون طيب 40 في 50 اتنين اتنين مليون إذا هاي اتنين
+
+110
+00:12:57,730 --> 00:13:06,330
+تنين مليون طيب الان هنا ع مستوى جسم المطارد حيكون
+
+111
+00:13:06,330 --> 00:13:14,750
+عندك جداش هنا ربح هو مليون تمام طيب الان هنا هنا
+
+112
+00:13:14,750 --> 00:13:22,330
+عندنا على مستوى الشركة ككل جداش تلاتة و مليون جداش
+
+113
+00:13:22,330 --> 00:13:32,980
+اربعة مليونهي أربع مليون تمام؟ طيب بالنسبة للتكليف
+
+114
+00:13:32,980 --> 00:13:38,000
+المتغير اتنين مليون وستمية ألف جداش؟ لأ اتنين
+
+115
+00:13:38,000 --> 00:13:45,000
+مليون وستمية ألف اتنين مليون وستمية ألف إذا الألف
+
+116
+00:13:45,000 --> 00:13:49,900
+هيطلع عندك هنا مليون وإيه؟ مليون واربعمية هاي
+
+117
+00:13:49,900 --> 00:13:52,860
+اتنين مليون وستمية نطرحها من أربع مليون مليون
+
+118
+00:13:52,860 --> 00:14:02,310
+واربعمية هنا ال ..أربعمائة ألف ومليون إذا كما
+
+119
+00:14:02,310 --> 00:14:08,090
+نلاحظ في البديل الأول في البديل الأول أن كل قسم في
+
+120
+00:14:08,090 --> 00:14:12,910
+حالة الاستقلالية أن كل قسم يحقق أيش يحقق أرباح وعن
+
+121
+00:14:12,910 --> 00:14:16,510
+مستوى الشركة يكون أيش اتنين مليون وستمية ما لديها
+
+122
+00:14:16,510 --> 00:14:23,930
+أي سؤال طيب نأتي إلى البديل التاني نأتي إلى البديل
+
+123
+00:14:23,930 --> 00:14:34,020
+التاني البديلالثاني التصنيع ايش داخليا ايش يعني
+
+124
+00:14:34,020 --> 00:14:41,240
+تصنيع داخليا يعني نخلي الجسم نخلي الجسم المحولات
+
+125
+00:14:41,240 --> 00:14:46,980
+اللي عندنا في داخل الشركة يحول part ويصنع المحول
+
+126
+00:14:46,980 --> 00:14:52,000
+اللي بحتاجه ال motor الجديد اللي اخترعته اخترعوا
+
+127
+00:14:52,000 --> 00:14:59,600
+هذا القسمقسم المحولات هنا يحول بالتكلفة، ما هيحول
+
+128
+00:14:59,600 --> 00:15:03,780
+بالتكلفة؟ مش هيحقق أرباح، الآن بتشوف مع بعض، طيب،
+
+129
+00:15:03,780 --> 00:15:07,980
+الآن هنا نفس
+
+130
+00:15:07,980 --> 00:15:17,620
+القصة، هذه بيان، وهنا هذه المحولات،
+
+131
+00:15:17,620 --> 00:15:22,220
+وهنا للوحدة، وهنا للجميع
+
+132
+00:15:23,670 --> 00:15:31,050
+تمام و هنا هاي
+
+133
+00:15:31,050 --> 00:15:41,210
+المجموع و هنا المطارات و هنا للوحدة و هنا للجميع
+
+134
+00:15:41,210 --> 00:15:50,710
+طيب انتبه هنا معايا انتبه معايا الآن عندنا هنا هاي
+
+135
+00:15:50,710 --> 00:16:05,290
+المبيعاتوهي تكاليف متغيرة وهي هامش المساهمة الآن
+
+136
+00:16:05,290 --> 00:16:09,870
+بالنسبة للمبيعات جسم المحولات هنا في حتة التصنيع
+
+137
+00:16:09,870 --> 00:16:15,430
+الداخلي للمطارات هذا هيبيعه في جداش؟ سعر؟ سعر عشرة
+
+138
+00:16:15,430 --> 00:16:20,570
+هيبيع بيهاش؟هو هيصنعله مخصوص جدّيش هيكلفه وبينما
+
+139
+00:16:20,570 --> 00:16:25,110
+يحاول على تكلفة هيحاوله طيب عشرة في خمسين خمسمية
+
+140
+00:16:25,110 --> 00:16:31,670
+.. خمسمية ألف طيب تكلفة المتغيرة عشرة في خمسين
+
+141
+00:16:31,670 --> 00:16:37,570
+خمسمية ألف إذا هل حقق هذا مش مساهمة؟في حالة انه
+
+142
+00:16:37,570 --> 00:16:42,070
+ينتج له صناع يحوله بيشما بكلفته ففي هذا الحالة
+
+143
+00:16:42,070 --> 00:16:46,550
+القسم البائع في حالة التحويل على أساس التكلفة لا
+
+144
+00:16:46,550 --> 00:16:52,630
+يحقق أي أرباح فبكون هنا ممكن يخلق مشكلة في عملية
+
+145
+00:16:52,630 --> 00:16:55,830
+الرقابة على الجودة يقولك ما أنا عايش ما أنا مافيش
+
+146
+00:16:55,830 --> 00:16:59,670
+حوافص مافيش أرباح بزيادة بناجس بجودة مش بجودة ماهو
+
+147
+00:16:59,670 --> 00:17:03,350
+مشكلة الان شوف هنا الان سواء قلنا اشترى من الداخل
+
+148
+00:17:03,350 --> 00:17:09,350
+ومن الخارج بدي بيعب كامبدي بيع كام؟ ستين سواء أخد
+
+149
+00:17:09,350 --> 00:17:13,290
+الجبعة من الداخل أو من الخارج ستين ستين في خمسين
+
+150
+00:17:13,290 --> 00:17:19,410
+في جديش تلاتة مليون طيب هنا اشترار من الداخل في
+
+151
+00:17:19,410 --> 00:17:27,530
+جديش زاد جديش يعني كام؟ يعني التكليف متغير أيش؟
+
+152
+00:17:27,530 --> 00:17:32,530
+خمسة وتلاتين طبعا؟ طيب إذا خمسة وتلاتين هنا هتكون
+
+153
+00:17:32,530 --> 00:17:33,410
+عندنا مليون
+
+154
+00:17:41,200 --> 00:17:50,420
+أربعة مليون ومتين وخمسين ألف مليون ومتين وخمسين
+
+155
+00:17:50,420 --> 00:17:59,680
+ألف تمام؟ طيب، الآن نكمل ومن ثم يكون التعليق ومن
+
+156
+00:17:59,680 --> 00:18:06,340
+ثم يكون التعليق الآن هنا عندناتلاتة مليون وهنا
+
+157
+00:18:06,340 --> 00:18:14,080
+خمسمائة ألف كده؟ تلاتة مليون طيب مليون سبعمائع و
+
+158
+00:18:14,080 --> 00:18:18,480
+خمسين و خمسمية اتنين
+
+159
+00:18:18,480 --> 00:18:24,300
+مليون و متين و خمسين ألف طبعا؟ طيب الآن لما نطلح
+
+160
+00:18:24,300 --> 00:18:28,600
+اتنين مليون و متين و خمسين و تلاتة مليون مليون و
+
+161
+00:18:28,600 --> 00:18:31,700
+متين و خمسين ألف
+
+162
+00:18:33,780 --> 00:18:38,600
+طيب الان كما تلاحظ هذا رقميا لو بدنا نعلق الان
+
+163
+00:18:38,600 --> 00:18:46,380
+عملية الاستقلالية لاحظ في عملية الاستقلالية ان قسم
+
+164
+00:18:46,380 --> 00:18:51,480
+المحولات ربح ايش 400 و قسم المحولات ربح ايش بإجمال
+
+165
+00:18:51,480 --> 00:18:56,540
+يبحث الشركة كام طيب انظر هنا في حتة تصنيع داخليا
+
+166
+00:18:56,540 --> 00:19:02,600
+ان القسم المحول ايشصار صفر قسم الحبولات صار ايه؟
+
+167
+00:19:02,600 --> 00:19:08,920
+صفر .. اه .. والربح اه صفر يعني هنا ماربحش لكن جسم
+
+168
+00:19:08,920 --> 00:19:13,140
+المطورات ايه اش؟ ارتفع ربحه كان مليون صار قد ايه
+
+169
+00:19:13,140 --> 00:19:17,680
+اش؟ تمام، ع مستوى الشركة كان مليون واربعمية صار قد
+
+170
+00:19:17,680 --> 00:19:23,010
+ايه اش؟يعني عملية التصنيع الداخليا إذا أتخذنا قرار
+
+171
+00:19:23,010 --> 00:19:30,090
+بهذا يلحق خسارة بالشركة يلحق خسارة بالشركة إيش؟
+
+172
+00:19:30,090 --> 00:19:35,090
+بمقدار الفرق بينهم الـ 150 ألف إذا هنا القرار
+
+173
+00:19:35,090 --> 00:19:40,490
+الصواب للشركة هو إيش؟ هو الاستقلالية والشراء من
+
+174
+00:19:40,490 --> 00:19:46,890
+الخارج مثلا إيه تعليق الاستعارات معاهم؟عادي بدك
+
+175
+00:19:46,890 --> 00:19:51,370
+تسنتين هيل هنا .. هنا بالنسبالي على مستوى الأقسام
+
+176
+00:19:51,370 --> 00:19:53,770
+.. هنا كان في البديل الأول هنا أربعمية .. هنا في
+
+177
+00:19:53,770 --> 00:19:57,230
+الشلو ربح .. هنا مليون صار مليون و خمسمية .. ع
+
+178
+00:19:57,230 --> 00:20:02,370
+مستوى الشركة ككل خسرت الشركة تخسر مية و خمسين ..
+
+179
+00:20:02,370 --> 00:20:03,210
+مية و خمسين ألف
+
+180
+00:20:15,610 --> 00:20:25,470
+سؤال آخر أي
+
+181
+00:20:25,470 --> 00:20:31,750
+سؤال جاهزين
+
+182
+00:20:31,750 --> 00:20:38,630
+سؤال آخر يوجد لدى شركة غزة الصناعية
+
+183
+00:20:44,480 --> 00:20:49,960
+مركزاء استثمار هنا قسم
+
+184
+00:20:49,960 --> 00:21:01,380
+تصنيع الثلاجات وقسم تصنيع الموتورات يعني الآن أحد
+
+185
+00:21:01,380 --> 00:21:06,700
+الشركات اللي تصنع الثلاجات ممكن تشتغل الهيكل
+
+186
+00:21:06,700 --> 00:21:12,200
+الثلاجي كلهو ممكن تصنع الموتور عندها داخليا و ممكن
+
+187
+00:21:12,200 --> 00:21:16,440
+تشتري الموتور من الخارج و تصنع بس هيكل التلاجة و
+
+188
+00:21:16,440 --> 00:21:29,900
+بس و تريح حالك طيب و يقوم قسم الموتورات بتصنيع
+
+189
+00:21:29,900 --> 00:21:33,020
+موتور التلاجة
+
+190
+00:21:35,210 --> 00:21:45,330
+وفي ميالي البيانات الخاصة بالتصنيع التكلفة
+
+191
+00:21:45,330 --> 00:21:51,690
+المتغيرة لإنتاج الموتور 100
+
+192
+00:21:51,690 --> 00:21:55,430
+درار التكلفة
+
+193
+00:21:55,430 --> 00:22:02,770
+الثابتة السنوية 70 ألف الطاقة الإنتاجية
+
+194
+00:22:04,870 --> 00:22:15,210
+الثانوية سبعمية ثلاجة احتاجات تصنيع .. احتاجات
+
+195
+00:22:15,210 --> 00:22:21,030
+تصنيع الثلاجات
+
+196
+00:22:21,030 --> 00:22:27,790
+الثانوية من الموتورات خمسمية احتاجات تصنيع
+
+197
+00:22:27,790 --> 00:22:33,410
+الثلاجات من الموتورات الثانوية خمسمية واحدة
+
+198
+00:22:34,390 --> 00:22:38,510
+المطلوب واحد
+
+199
+00:22:38,510 --> 00:22:41,610
+تحديد
+
+200
+00:22:41,610 --> 00:22:48,470
+سعر التحويل للمطور
+
+201
+00:22:48,470 --> 00:22:52,750
+بناء على طريقة التكاليف
+
+202
+00:22:54,870 --> 00:23:00,650
+المتغيرة بناء على طريقة التكاليف المتغيرة وعندما
+
+203
+00:23:00,650 --> 00:23:05,690
+نقول تكاليف متغيرة يعني ايش فقط التكلفة المتغيرة
+
+204
+00:23:05,690 --> 00:23:12,430
+اذا واحد سعر التحويل بناء على المطلوب يساوي
+
+205
+00:23:12,430 --> 00:23:17,770
+التكلفة المتغيرة
+
+206
+00:23:17,770 --> 00:23:22,130
+وتساوي مئة دولار
+
+207
+00:23:24,150 --> 00:23:32,230
+متساوى مئة دينارة طيب
+
+208
+00:23:32,230 --> 00:23:41,850
+اتنين تحديد سعر التحويل تحديد سعر التحويل بناء على
+
+209
+00:23:41,850 --> 00:23:47,030
+طريقة التكلفة المتغيرة بناء على طريقة التكلفة
+
+210
+00:23:47,030 --> 00:23:59,940
+المتغيرة مع إضافة خمسين في الميةمن التكلفة كخامش
+
+211
+00:23:59,940 --> 00:24:11,060
+ربح كخامش ربح طيب الآن هيكون سعر التحويل يساوي
+
+212
+00:24:11,060 --> 00:24:20,300
+التكلفة المتغيرة زائد قداش قولنا في 30%؟ خمسين في
+
+213
+00:24:20,300 --> 00:24:31,820
+المية خمسين في الميةهامش ربح طبعا من التكلفة ويقصد
+
+214
+00:24:31,820 --> 00:24:36,340
+التكلفة التكلفة المتغيرة مش انا بقولك التحديث على
+
+215
+00:24:36,340 --> 00:24:40,000
+التحويل من التكلفة المتغيرة لزاد 50% من التكلفة
+
+216
+00:24:40,000 --> 00:24:51,120
+كهامش ربح إذا يساوي 100 زاد 50% ضرب 100و يساوي مية
+
+217
+00:24:51,120 --> 00:24:59,280
+زائد خمسين و يساوي مية و خمسين دنا و يساوي مية و
+
+218
+00:24:59,280 --> 00:25:13,440
+خمسين دنا تمام ؟ طيب نطلب التالت نطلب التالت تحديث
+
+219
+00:25:13,440 --> 00:25:17,930
+سهل التحويلتحديد سعر التحويل بناء على التكلفة
+
+220
+00:25:17,930 --> 00:25:26,210
+الكلية سعر
+
+221
+00:25:26,210 --> 00:25:41,750
+التحويل يساوي التكلفة المتغيرة زائد نصيب الوحدة من
+
+222
+00:25:41,750 --> 00:25:43,670
+التكاليف
+
+223
+00:25:45,610 --> 00:25:55,650
+الثابتة و يساوي مية زائد زائد سبعين الف سبعين الف
+
+224
+00:25:55,650 --> 00:26:03,330
+التكريف الثابت السنوية تقسيم سبعميت واحدة إذا زائد
+
+225
+00:26:03,330 --> 00:26:10,630
+مية يساوي مية زائد مية وتساوي اللي هو أيه؟ متان
+
+226
+00:26:10,630 --> 00:26:12,290
+دولار
+
+227
+00:26:17,420 --> 00:26:21,960
+ما لدي أي سعر طيب
+
+228
+00:26:21,960 --> 00:26:30,640
+مطلوب الرابع تحديد سعر التحويل بناء على التكلفة
+
+229
+00:26:30,640 --> 00:26:43,640
+الكلية مضافا إليه 40% هامش ربح من التكلفة إذا نقول
+
+230
+00:26:43,640 --> 00:26:53,070
+سعر التحويليساوي التكلفة الكلية زائد أربعين في
+
+231
+00:26:53,070 --> 00:26:59,830
+المية من إيش التكلفة ويساوي التكلفة الكلية قبل
+
+232
+00:26:59,830 --> 00:27:00,670
+شوية حسب ده
+
+233
+00:27:04,670 --> 00:27:15,950
+هذه 200 زائد 200 ضرب ايش ضرب 40% ويساوي 200 زائد
+
+234
+00:27:15,950 --> 00:27:26,850
+80 ويساوي 280 دينار مال
+
+235
+00:27:26,850 --> 00:27:32,390
+ليه اي سؤال؟ مين عنده اي سؤال؟
+
+236
+00:27:48,430 --> 00:27:54,210
+من اليسار الشباب طبعا
+
+237
+00:27:54,210 --> 00:28:04,490
+اخيرا نتحدث عن سعر السوق market
+
+238
+00:28:04,490 --> 00:28:07,610
+price
+
+239
+00:28:07,610 --> 00:28:12,750
+سعر
+
+240
+00:28:12,750 --> 00:28:15,890
+السوق سعر السوق
+
+241
+00:28:17,940 --> 00:28:24,460
+سعر السوق هو السعر اللذي تحدده السوق المفتوحة هو
+
+242
+00:28:24,460 --> 00:28:30,980
+السعر اللذي تحدده السوق المفتوحة ايش يعني؟ يعني
+
+243
+00:28:30,980 --> 00:28:36,100
+حسب سعر الموجود يتداول في السوق القسم البائع، جسم
+
+244
+00:28:36,100 --> 00:28:40,180
+المطاحن، بيقول لو تاحن المخابز أنا ببيع في السوق
+
+245
+00:28:40,180 --> 00:28:47,470
+الشوال بخمسين شكل، بدك تاخده بخمسين، زيك زيهمهذه
+
+246
+00:28:47,470 --> 00:28:56,930
+معناه السعر طيب بعبارة أخرى هنا ويعتبر سعر السوق
+
+247
+00:28:56,930 --> 00:29:05,570
+ويعتبر سعر السوق الأسلوب الأفضل الأسلوب الأفضل
+
+248
+00:29:05,570 --> 00:29:14,850
+لمواجهة مشكلة أسعار التحويل لمواجهة مشكلة أسعار
+
+249
+00:29:14,850 --> 00:29:16,290
+التحويل
+
+250
+00:29:21,170 --> 00:29:24,650
+بمعنى اخر عندما نتحدث عن سعر السوق ايش معناه
+
+251
+00:29:24,650 --> 00:29:30,150
+المعنى اللي هو التحويل يعني جسم هى البائع زى ما
+
+252
+00:29:30,150 --> 00:29:38,470
+قلنا المطاحن و هنا المشتري المخابز بتم تحويل اللى
+
+253
+00:29:38,470 --> 00:29:43,030
+هو البضاعة بناء على ايش سعر ايش بتجيه فى السوق
+
+254
+00:29:43,030 --> 00:29:50,070
+بناء على سعر اللى هو السوق هذا هيك بتكون احنا
+
+255
+00:29:51,600 --> 00:30:00,560
+انتهينا من موضوع أسعار التحويل وبهذا نكون وصلنا
+
+256
+00:30:00,560 --> 00:30:05,860
+إلى نهاية محاضرة اليوم ولقانا في المحاضرة القادمة
+
+257
+00:30:05,860 --> 00:30:09,400
+وهي الختامية ان شاء الله إلى اللقاء
+
diff --git a/PL9fwy3NUQKwboNQTWPePHoN8dlQDul_Y4/iQaBusrt3W0_postprocess.srt b/PL9fwy3NUQKwboNQTWPePHoN8dlQDul_Y4/iQaBusrt3W0_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..96583db2e54396a35dd855a2bf28d1d6d8173724
--- /dev/null
+++ b/PL9fwy3NUQKwboNQTWPePHoN8dlQDul_Y4/iQaBusrt3W0_postprocess.srt
@@ -0,0 +1,1380 @@
+1
+00:00:19,390 --> 00:00:26,390
+أعزائي الطلاب استكمالا لموضوع الموازنة في المحاضرة
+
+2
+00:00:26,390 --> 00:00:29,090
+الماضية وصلنا في نهاية المحاضرة إعداد موازنة
+
+3
+00:00:29,090 --> 00:00:35,570
+الإنتاجموازن إنتاج كان الهدف منها الوصول إلى عدد
+
+4
+00:00:35,570 --> 00:00:39,510
+الوحدات أو معرفة عدد الوحدات الواجب إنتاجها كل
+
+5
+00:00:39,510 --> 00:00:46,490
+فترة من هذه الفترات وبعد ما توصلنا إلى عدد الوحدات
+
+6
+00:00:46,490 --> 00:00:51,630
+الواجب إنتاجها أن كل وحدة عادة لها مكونات ثلاث
+
+7
+00:00:51,630 --> 00:00:58,370
+ثلاث أي الوحدة تحتاج إلى مواد إلى أجور إلى مصاريف
+
+8
+00:00:58,370 --> 00:01:07,480
+غيرمباشرة إذا بعد إعداد موازنة الإنتاج يكون أمامنا
+
+9
+00:01:07,480 --> 00:01:13,260
+إعداد ثلاث موازنات متعلقة بالوحدات المنتجة وهي
+
+10
+00:01:13,260 --> 00:01:18,700
+موازنة المواد المباشرة وموازنة العمل المباشر
+
+11
+00:01:18,700 --> 00:01:24,840
+وموازنة المصاريف غير المباشرة نبدأنبدأ الآن
+
+12
+00:01:24,840 --> 00:01:35,320
+بموازنة المواد الخام المباشرة موازنة المواد
+
+13
+00:01:35,320 --> 00:01:48,440
+الخام المباشرة diet
+
+14
+00:01:48,440 --> 00:01:50,720
+material budget
+
+15
+00:01:55,090 --> 00:02:03,850
+موازنات المواد الخام المباشرة يهدف
+
+16
+00:02:03,850 --> 00:02:13,330
+إعداد هذه الموازنة يهدف إعداد هذه الموازنة إلى
+
+17
+00:02:13,330 --> 00:02:25,680
+إظهار كميةالمواد اللازمة للإنتاج والكمية
+
+18
+00:02:25,680 --> 00:02:36,240
+الواجب شرائها خلال كل فترة من الفترات وكذلك
+
+19
+00:02:36,240 --> 00:02:45,400
+المبالغ اللازمةلتأمين هذه المشتريات وكذلك المبالغ
+
+20
+00:02:45,400 --> 00:02:53,740
+اللازمة لتأمين شراء هذه الكميات وعند إعداد موازنة
+
+21
+00:02:53,740 --> 00:02:58,600
+المواد الخام وعند إعداد موازنة المواد الخام
+
+22
+00:02:58,600 --> 00:03:05,080
+المباشرة يتطلب توفير الأمور أو البيانات التالية
+
+23
+00:03:05,080 --> 00:03:12,140
+واحدكمية المواد المباشرة رقم واحد كمية المواد
+
+24
+00:03:12,140 --> 00:03:20,300
+المباشرة اللازمة للوحدة اللازمة للوحدة رقم اتنين
+
+25
+00:03:20,300 --> 00:03:25,380
+سعر سعر
+
+26
+00:03:25,380 --> 00:03:39,420
+كمية المواد سعر كمية المواد رقم تلاتيكمية الإنتاج
+
+27
+00:03:39,420 --> 00:03:50,100
+المتوقع إنتاجها رقم أربعة كمية المواد الخام في
+
+28
+00:03:50,100 --> 00:03:57,740
+بداية الفترة كمية المواد الخام في بداية الفترة و
+
+29
+00:03:57,740 --> 00:04:00,620
+كذلك نهاية الفترة
+
+30
+00:04:04,250 --> 00:04:11,230
+لتوضيح عملية إعداد الموازنة المواد المباشرة
+
+31
+00:04:13,580 --> 00:04:18,260
+نأخذ المثال التالي وهو مرتبط بالمثال الرقم واحد
+
+32
+00:04:18,260 --> 00:04:23,600
+طبعا الشباب هنا موازنة المواد الخام المباشرة احنا
+
+33
+00:04:23,600 --> 00:04:27,780
+زي ما حكينا هنشوف كمية المواد اللي عايزينها ثم ايش
+
+34
+00:04:27,780 --> 00:04:32,600
+الفلوس اللي عايزها انا كل شهر طيب لكن كل شهر انا
+
+35
+00:04:32,600 --> 00:04:38,060
+محتاج مثلا عشر تلاف درارمواد هل 10000 دنار هذه
+
+36
+00:04:38,060 --> 00:04:43,080
+بستطيع ان اقوم بدفعها خلال شهر الشراء طبعا حسب
+
+37
+00:04:43,080 --> 00:04:47,400
+الخبرات ممكن انا ادفع جزء في شهر الشراء جزء في
+
+38
+00:04:47,400 --> 00:04:53,160
+الشهر الذي يليه او جزء في شهر الشراء والباقي في
+
+39
+00:04:53,160 --> 00:05:02,640
+أشهر الأخرى الان ناخد مثال وهو مرتبط بمثال رقم1
+
+40
+00:05:02,640 --> 00:05:15,580
+إذا هنا الآن بيقول تابع مثال رقم 1 توفرت
+
+41
+00:05:15,580 --> 00:05:23,740
+لديك البيانات التالية رقم 1 عدد الوحدات المتوقع
+
+42
+00:05:23,740 --> 00:05:30,660
+إنتاجهارقم واحد عدد الوحدات المتوقع إنتاجها خلال
+
+43
+00:05:30,660 --> 00:05:37,300
+الأربع شهور الأولى خلال الأربع شهور الأولى لعام
+
+44
+00:05:37,300 --> 00:05:45,660
+الفين و تمانتاش على التوالي على التوالي الفين و
+
+45
+00:05:45,660 --> 00:05:52,220
+ستمائة وحدة اربع آلاف و ستمائة الفين و تسعمائة
+
+46
+00:05:55,340 --> 00:06:03,280
+و 2300 وحدة اذا كما قلت هذه الوحدات 2600 و 4000 و
+
+47
+00:06:03,280 --> 00:06:08,140
+600 و 1900 و 1300 على التوالي يناير 2600 فبراير
+
+48
+00:06:08,140 --> 00:06:17,040
+2400 و 600 و هكذا رقم اتنين تحتاج الوحدة من
+
+49
+00:06:17,040 --> 00:06:23,440
+المعادل الخامتحتاج الوحدة من المواد الخام خمسة
+
+50
+00:06:23,440 --> 00:06:32,580
+كيلو غرام رقم
+
+51
+00:06:32,580 --> 00:06:45,810
+تلاتة تحتفظ الشركة بنسبةتحتفظ الشركة بنسبة 10%
+
+52
+00:06:45,810 --> 00:06:50,670
+من مخزون المواد
+
+53
+00:06:50,670 --> 00:06:58,850
+الخام من الشهر
+
+54
+00:06:58,850 --> 00:07:06,350
+التالي للشهر
+
+55
+00:07:06,350 --> 00:07:12,640
+الحاليرقم أربعة رصيد مخزون أول المدة من المواد
+
+56
+00:07:12,640 --> 00:07:18,920
+الخام رصيد مخزون أول المدة من المواد الخام لعام
+
+57
+00:07:18,920 --> 00:07:26,120
+الفين و تمانتاش لعام الفين و تمانتاش الف وتلاتمية
+
+58
+00:07:26,120 --> 00:07:34,720
+كيلو غرام الف تلاتمية كيلو غرام رقم خمسة رقم خمسة
+
+59
+00:07:35,490 --> 00:07:42,590
+تكلفة الكلغرام الواحد تكلفة الكلغرام الواحد أربعة
+
+60
+00:07:42,590 --> 00:07:51,050
+من عشرة دينار رقم ستة تدفع
+
+61
+00:07:51,050 --> 00:07:57,210
+الشركة خمسين في المية من ثمن المشتريات تدفع الشركة
+
+62
+00:07:57,210 --> 00:08:04,620
+خمسين في المية من ثمنالمشتريات في نفس الشهر في نفس
+
+63
+00:08:04,620 --> 00:08:11,440
+الشهر وخمسين في المية الباقية وخمسين في المية
+
+64
+00:08:11,440 --> 00:08:21,220
+الباقية في الشهر التالي نقطة رقم سبعة وأخيرا بلغة
+
+65
+00:08:21,220 --> 00:08:22,440
+نصيد الموردين
+
+66
+00:08:24,580 --> 00:08:30,120
+الف وتمنمية الف و متين دنار بلغ رصيد الموردين الف
+
+67
+00:08:30,120 --> 00:08:37,180
+و متين دنار في واحد و تلاتين اتناش الفين و سبعتاش
+
+68
+00:08:37,180 --> 00:08:40,260
+المطلوب
+
+69
+00:08:40,260 --> 00:08:49,540
+واحد اعداد موازنة المواد الخام المباشرة للربع
+
+70
+00:08:49,540 --> 00:09:00,320
+الأول للربع الأولمن عام 2018 رقم اتنين اعداد
+
+71
+00:09:00,320 --> 00:09:07,740
+موازنة التدفقات النقدية المتوقعة اعداد موازنة
+
+72
+00:09:07,740 --> 00:09:16,680
+التدفقات النقدية المتوقعة لربع الاول من عام 2018
+
+73
+00:09:16,680 --> 00:09:20,980
+اذا الان الحل
+
+74
+00:09:24,200 --> 00:09:39,020
+واحد موازنة المواد الخام المباشرة بيان
+
+75
+00:09:39,020 --> 00:09:42,600
+يانيار
+
+76
+00:09:42,600 --> 00:09:49,560
+فبراير مارس إبريل
+
+77
+00:10:01,340 --> 00:10:10,800
+إذا عند إعداد موازنة المواد الخام يكون أمامنا أو
+
+78
+00:10:10,800 --> 00:10:17,300
+أول شيء لبدأ به عدد الوحدات المتوقع إنتاجها عدد
+
+79
+00:10:17,300 --> 00:10:28,500
+عدد الوحدات المتوقع إنتاجها وهذه تأتي من موازنة
+
+80
+00:10:28,500 --> 00:10:35,640
+إيه؟من وين تأتي؟ من وين تأتي هاي؟ من موازنة
+
+81
+00:10:35,640 --> 00:10:41,580
+الإنتاج إذا هاي نرجع إلى موازنة الإنتاج ونحصل
+
+82
+00:10:41,580 --> 00:10:47,480
+عليها ولكن في السؤال أُعطيت لنا هنا ألفين وستمية
+
+83
+00:10:47,480 --> 00:10:55,400
+واحدة أربعة آلاف وستمية ألفين وتسعمية ألفين
+
+84
+00:10:55,400 --> 00:11:04,480
+وتلاتمية واحدةإذا موازنة الخام المباشرة نبدأ
+
+85
+00:11:04,480 --> 00:11:09,680
+بالوحدات المتوقعة إنتاجها ونحصل عليها من موازنة
+
+86
+00:11:09,680 --> 00:11:22,160
+الإنتاج السابقة الآن ضرب الوزن الوزن هنا كل وحدة
+
+87
+00:11:22,160 --> 00:11:28,360
+حسب المعلومة الموطاة في السؤال خمسة أيش؟ خمسة كيلو
+
+88
+00:11:28,990 --> 00:11:35,210
+تمام؟ إذن الآن هنا
+
+89
+00:11:35,210 --> 00:11:47,800
+اللي هي كمية المواد الخام تمام؟ اللي هي كيلوكمية
+
+90
+00:11:47,800 --> 00:11:54,480
+المواد الخالية المتعلقة بعدد الوحدات المتوقعة
+
+91
+00:11:54,480 --> 00:12:03,320
+انتاجها خمسة في الفين ستمائية ستكون كم تلتاشر
+
+92
+00:12:03,320 --> 00:12:13,970
+الف هنا تلاتة عشرين الف وهناأربعة عشر ألف وخمسمية
+
+93
+00:12:13,970 --> 00:12:22,210
+وهنا أحد عشر ألف وخمسمية إذا الخطوة الأولى في
+
+94
+00:12:22,210 --> 00:12:26,230
+إعداد موازنة المواد الخام المباشرة هو عدد وحدات
+
+95
+00:12:26,230 --> 00:12:31,970
+المتوقعة وكم يلزم من الوزن أو من الكمية اللازمة
+
+96
+00:12:31,970 --> 00:12:36,970
+للإنتاج ونحولها إلى كيلو غرامات لأن في النهاية
+
+97
+00:12:36,970 --> 00:12:43,070
+أعطانا سعر الكيلو أربعة من عشرة دنارما لديها أي
+
+98
+00:12:43,070 --> 00:12:56,170
+سؤال؟ الآن نأتي إلى زائد مخزون آخر
+
+99
+00:12:56,170 --> 00:13:05,690
+المدة من المواد الخام المباشرة
+
+100
+00:13:07,490 --> 00:13:15,110
+وكما ذكر لدينا أن الشركة تحتفظ بنسبة 10% بنسبة
+
+101
+00:13:15,110 --> 00:13:21,390
+عشرة في المية بنسبة عشرة في المية إذا نسبة العشرة
+
+102
+00:13:21,390 --> 00:13:25,850
+في المية أمر يعني حسب المعلومة المتوفرة تحتفظ
+
+103
+00:13:25,850 --> 00:13:30,390
+الشركة للشهر الحالي بنسبة عشرة في المية من الشهر
+
+104
+00:13:30,390 --> 00:13:39,660
+إيش التالي إذا هنا هنا هايعشرة في المية هاي عشرة
+
+105
+00:13:39,660 --> 00:13:46,120
+في المية هاي عشرة في المية تمام؟ إذا الآن هنا
+
+106
+00:13:46,120 --> 00:13:54,040
+الفين و تلاتمية الفينعشرة في المية من تلاتة وعشرين
+
+107
+00:13:54,040 --> 00:13:57,120
+ألف الفين وتلاتمية عشرة في المية اربعتاشر ألف
+
+108
+00:13:57,120 --> 00:14:02,380
+وخمسمية ألف واربعمية وخمسين وكذلك عشرة في المية من
+
+109
+00:14:02,380 --> 00:14:09,140
+إحداشر ألف وخمسمية ألف ومية واش وخمسين إذا بهذا
+
+110
+00:14:09,140 --> 00:14:16,060
+نصل الآن نقوم بجمع الكمية اللازمة للإنتاج بالإضافة
+
+111
+00:14:16,060 --> 00:14:25,420
+إلى المخزون آخر المدة نصل إلىاللي هي كمية المواد
+
+112
+00:14:25,420 --> 00:14:32,840
+الخام المطلوبة المطلوبة
+
+113
+00:14:32,840 --> 00:14:38,940
+المطلوبة إذا هنا هيكون لدينا خمستاشر ألف و تلتمية
+
+114
+00:14:38,940 --> 00:14:44,360
+تمام هنا هيكون عندنا أربع عشرين ألف و أربعمية و
+
+115
+00:14:44,360 --> 00:14:55,010
+خمسين هنا هيكون عندنا خمستاشر ألفوستمية وخمسين اذا
+
+116
+00:14:55,010 --> 00:15:00,490
+انا قمت بجمع الكمية التلتاشر الف كمية اللازمة اللي
+
+117
+00:15:00,490 --> 00:15:05,790
+هي جاية من عدد الوحدات المتوقعة انتاجها في الكمية
+
+118
+00:15:05,790 --> 00:15:10,070
+بالاضافة الكمية الواجب ان تحتفظ بيها الشركة اللي
+
+119
+00:15:10,070 --> 00:15:13,830
+هي عشرة فالمية من الشهر التالي للشهر ايش الحالي
+
+120
+00:15:13,830 --> 00:15:25,300
+اذا هنا كمية المواد المطلوبة نأتيالان الى الى ناقص
+
+121
+00:15:25,300 --> 00:15:38,020
+مخزون اول المدة من المواد الخام المباشرة من المواد
+
+122
+00:15:38,020 --> 00:15:41,320
+الخام المباشرة
+
+123
+00:15:45,450 --> 00:15:51,090
+الان مخزون اخر المدة كما اعطيه في السؤال لديك ان
+
+124
+00:15:51,090 --> 00:15:59,210
+مخزون اول المدة في السؤال كام؟ الف و هو ايش؟
+
+125
+00:15:59,210 --> 00:16:03,110
+تلاتمية كيلو درهم تلاتمية درهم اذا نقوم بتسجيله
+
+126
+00:16:03,110 --> 00:16:12,230
+هنا الف وتلاتمية تمام؟ تمام طيبالان ايضا مخزون اخر
+
+127
+00:16:12,230 --> 00:16:20,190
+المدة لفترة ما يعتبر مخزون .. مخزون ايش؟ مخزون اول
+
+128
+00:16:20,190 --> 00:16:26,790
+المدة للفترة التالية وضعت لك الأسهم نتوضع الان هنا
+
+129
+00:16:26,790 --> 00:16:34,850
+هي الفين و تلتمية .. الفين و تلتمية طيب هنا الف و
+
+130
+00:16:34,850 --> 00:16:42,440
+أربعمية و خمسين1450 إذا كما تلاحظ بعد موصولنا
+
+131
+00:16:42,440 --> 00:16:48,200
+الكمية المطلوبة في كل شهر لابد من طرح كمية المخزون
+
+132
+00:16:48,200 --> 00:16:52,820
+اللي هي اللتي تخص المخزون أول اللي بده وكما أعطي
+
+133
+00:16:52,820 --> 00:17:00,510
+لدينا في السؤال هى 1300 تمام هى 1300ومن ثم ما هو
+
+134
+00:17:00,510 --> 00:17:04,610
+آخر مدة لفترة ما يعتبر أول مدة للفترة التالية
+
+135
+00:17:04,610 --> 00:17:10,230
+وكذلك الـ 1450. الآن نقوم بعملية إيه؟ بعملية
+
+136
+00:17:10,230 --> 00:17:21,930
+الطرح. إذا هنا تسمى الكمية اللازم شراءها اللي هي
+
+137
+00:17:21,930 --> 00:17:31,630
+كيلو غرام. طبعا هذه هنا.واجب شرائها تمام الواجب
+
+138
+00:17:31,630 --> 00:17:36,490
+شرائها هترحل الف و تلاتمية من خمستاشر الف و إيه؟
+
+139
+00:17:36,490 --> 00:17:44,010
+تلاتمية هتكون لديا كام؟ اربعتاشر الف وهنا الفين و
+
+140
+00:17:44,010 --> 00:17:48,770
+تلاتمية هيكون اتنين وعشرين الف ومية وإيش؟ مية
+
+141
+00:17:48,770 --> 00:17:56,860
+وخمسين وهنا .. وهنا الف واربعمية وخمسين هتكونأربعة
+
+142
+00:17:56,860 --> 00:17:59,000
+عشر ألف و متين
+
+143
+00:18:04,390 --> 00:18:10,650
+اللازم شراها بالكيلورام هذه ككمية وكما قلت في
+
+144
+00:18:10,650 --> 00:18:14,290
+البداية أن الهدف من إعداد موازنة المواد الخام
+
+145
+00:18:14,290 --> 00:18:18,870
+معرفة الكمية اللازمة للإنتاج والكمية الواجب شراها
+
+146
+00:18:18,870 --> 00:18:24,410
+أضف إلى ذلك اللي هو أيش المبالغ اللازمة لتأمين
+
+147
+00:18:24,410 --> 00:18:31,770
+شراء هذه الكمية إذا الآن هنا ما لديها أي سؤال الآن
+
+148
+00:18:31,770 --> 00:18:43,500
+هنا نقولسعر الشراء سعر الشراء سعر الشراء كام؟ اقيا
+
+149
+00:18:43,500 --> 00:18:50,700
+في السؤال 410 دولار اذا كما تلاحظ اذا هنا نقول
+
+150
+00:18:50,700 --> 00:18:54,840
+اجمالي المبالغ
+
+151
+00:18:55,960 --> 00:18:59,520
+إجمال المبالغ معنى الكلام إنه أنا في الشهر يناير
+
+152
+00:18:59,520 --> 00:19:07,960
+محتاج إيه؟ خمس آلاف وستمية دولار وهنا ثمان آلاف
+
+153
+00:19:07,960 --> 00:19:21,160
+وتمنمية وستين وهنا وهنا خمس آلاف ستمية وتمانية الف
+
+154
+00:19:21,160 --> 00:19:30,520
+دولار هذا هوهذا هو اللي هو أيه موازنة المعادل
+
+155
+00:19:30,520 --> 00:19:34,120
+الخام ومثل كميات المطلوب والكميات الواجب شراها
+
+156
+00:19:34,120 --> 00:19:40,040
+وإجمالي المبالغ اللازمة فيه كل شهر ما اللي لديه أي
+
+157
+00:19:40,040 --> 00:19:49,380
+سؤال ما اللي لديه أي سؤال طيب ننتقل الآن إلى رقم
+
+158
+00:19:49,380 --> 00:19:53,980
+اتنين رقم اتنين موازنة
+
+159
+00:19:55,410 --> 00:20:05,850
+موازنة ايش؟ التدفقات النقدية المتوقعة خلال الربع
+
+160
+00:20:05,850 --> 00:20:14,630
+.. خلال الربع الأول خلال الربع الأول هنا الربع
+
+161
+00:20:14,630 --> 00:20:21,810
+الأول نكتفي بالربع الأول هي يانيار فبراير وهنا في
+
+162
+00:20:21,810 --> 00:20:24,090
+النهاية مارس
+
+163
+00:20:25,730 --> 00:20:32,490
+بكافي وهنا بيان، وهنا بيان إذا عند بداية هذه
+
+164
+00:20:32,490 --> 00:20:38,770
+الموازنة موازنة التضافقات النقدية المتوقعة هل يوجد
+
+165
+00:20:38,770 --> 00:20:43,290
+رصيد للموردين كما ذكر لنا في الـBand رقم 7 نعم أنا
+
+166
+00:20:43,290 --> 00:20:47,650
+الألف المشتريات بشتري من تجار إذا هدول موردين إذا
+
+167
+00:20:47,650 --> 00:21:00,930
+هنا لدينا رصيد رصيد إيش؟رصيد 112018 كام؟ ألف ومتين
+
+168
+00:21:00,930 --> 00:21:08,520
+دينارالف و بيتين دينار طيب الان نأتي و كما قلنا في
+
+169
+00:21:08,520 --> 00:21:13,760
+السؤال و حسب الخبرة متوقع انه يدفع و حسب مقداراته
+
+170
+00:21:13,760 --> 00:21:17,900
+يدفع 50% من ثمن الشراك في شهر الشراك و 50% التانية
+
+171
+00:21:17,900 --> 00:21:26,100
+ايه؟ في الشهر التالي اذا الان بنقول هنا هنا هنا
+
+172
+00:21:26,100 --> 00:21:34,780
+يناير يناير خمسين في المية ضرب ايش؟درب ايش؟ درب
+
+173
+00:21:34,780 --> 00:21:39,620
+خمس آلاف وستمية خمس آلاف مش هي قيمة مشترياتي أنا
+
+174
+00:21:39,620 --> 00:21:43,820
+هدفع منه خمسين في المية في شهر يناير هاي خمس آلاف
+
+175
+00:21:43,820 --> 00:21:49,340
+واش؟ وستمية وخمسين في المية التانية هتكون في الشهر
+
+176
+00:21:49,340 --> 00:21:54,700
+التالي إذا هنا الفين و تمانية في شهر يناير هدفع
+
+177
+00:21:54,700 --> 00:21:58,900
+واش؟ الفين و تمانية في شهر فبراير الفين و تمانية
+
+178
+00:21:58,900 --> 00:22:04,180
+لاحظ في شهر فبراير في الشهر الذي يليهو ممكن يكون
+
+179
+00:22:04,180 --> 00:22:12,620
+على ثلاث شهور طيب، الآن نذهب إلى شهر إيش؟ شهر إيش؟
+
+180
+00:22:12,620 --> 00:22:19,700
+February خمسين في المية ضرب إيش؟ تمان آلاف وستمية
+
+181
+00:22:19,700 --> 00:22:27,460
+ثمان آلاف وتمنمية وإيش؟ وستينتمام؟ القيمة هحصل
+
+182
+00:22:27,460 --> 00:22:30,720
+خمسين في المية من .. من مشتريات .. هدفع خمسين في
+
+183
+00:22:30,720 --> 00:22:33,740
+المية من مشتريات شهر فبراير وهي عبارة عن اربعة
+
+184
+00:22:33,740 --> 00:22:41,180
+آلاف واربعمية وإيش؟ وتلاتين تمام؟ طيب الآن خمسين
+
+185
+00:22:41,180 --> 00:22:47,920
+في المية التانية ضرب إيش؟ ضرب المبلغ هتكون هنا
+
+186
+00:22:47,920 --> 00:22:54,900
+اربع آلاف واربعمية وإيه؟ وتلاتين تلاتينما لديه أي
+
+187
+00:22:54,900 --> 00:23:01,300
+سؤال نذهب إلى شهر مارس، نذهب إلى شهر، إلى شهر
+
+188
+00:23:01,300 --> 00:23:09,460
+مارس، إلى شهر مارس، okay مارس خمسين
+
+189
+00:23:09,460 --> 00:23:15,320
+في المية ضرب، ضرب خمس آلاف وستمية وإيش؟ ضرب إيه؟
+
+190
+00:23:15,320 --> 00:23:22,480
+خمس آلاف وستمية وتمانين، خمس آلاف وستمية وتمانين
+
+191
+00:23:23,120 --> 00:23:28,080
+طبعاً هذه اللي هي مشتريات مارس هيكون عندنا 1800 ..
+
+192
+00:23:28,080 --> 00:23:34,860
+1840 طبعاً هو حكى لي في السؤال عايز التدفقات
+
+193
+00:23:34,860 --> 00:23:40,040
+النقدية خلال الربع الأول خلال تلات شهور كمان واحد
+
+194
+00:23:40,040 --> 00:23:46,940
+بس ماكملش أنا اضطريت سابقاً أكمل لظرف معين لأغراض
+
+195
+00:23:46,940 --> 00:23:56,320
+معينة عشان أوضح إذا هنا مجموعةالتدفقات النقدية
+
+196
+00:23:56,320 --> 00:24:05,140
+المتوقعة تمام؟ إذن في شهر يناير حيكون إجمال
+
+197
+00:24:05,140 --> 00:24:12,060
+التدفقات النقدية المتوقعة عندي كام؟ أربع ألف و هنا
+
+198
+00:24:12,060 --> 00:24:23,100
+خمس .. هنا حيكون عندي سبع آلاف و متين و تلاتينوهنا
+
+199
+00:24:23,100 --> 00:24:33,520
+هيكون عندى سبع آلاف و متين و سبعين اذا بهذا نكون
+
+200
+00:24:33,520 --> 00:24:39,620
+وصلنا الى المطلوب الثاني بهذا نكون وصلنا الى
+
+201
+00:24:39,620 --> 00:24:45,640
+المطلوب الثاني مال
+
+202
+00:24:45,640 --> 00:24:47,160
+لديه أي سؤال؟
+
+203
+00:24:49,620 --> 00:24:56,720
+إذا قلنا إن هذه البيانات تابعة للمثال رقم واحد
+
+204
+00:24:56,720 --> 00:25:04,600
+والآن سوف نكرر هذا الأمر وارتباطا بالمثال رقم
+
+205
+00:25:04,600 --> 00:25:12,900
+اتنين ما اللي لديه أي سؤال الآن
+
+206
+00:25:12,900 --> 00:25:27,560
+ندعوتابع مثال رقم 2 تابع مثال رقم 2 توفرت لديك
+
+207
+00:25:27,560 --> 00:25:35,260
+البيانات التالية توفرت لديك البيانات التالية واحد
+
+208
+00:25:35,260 --> 00:25:43,250
+عدد الوحدات المتوقع إنتاجهاخلال الأربع شهور عدد
+
+209
+00:25:43,250 --> 00:25:47,730
+الوحدات المتوقع إنتاجها خلال الأربع شهور الأولى
+
+210
+00:25:47,730 --> 00:25:58,050
+خلال الأربع شهور الأولى لعام 2014 على التوالي على
+
+211
+00:25:58,050 --> 00:26:07,390
+التوالي 2700 2400 5800
+
+212
+00:26:09,860 --> 00:26:13,140
+الفين و أربعمية .. الفين و سبعمية الفين و أربعمية
+
+213
+00:26:13,140 --> 00:26:18,020
+خمس آلاف و تمانمية وأخيراً ثلاث آلاف و تمانمية و
+
+214
+00:26:18,020 --> 00:26:24,540
+خمسين رقم اتنين رقم اتنين تحتاج ال .. تحتاج كل
+
+215
+00:26:24,540 --> 00:26:32,980
+وحدة تحتاج كل وحدة تحتاج كل وحدة إلى عشرة كيلو
+
+216
+00:26:32,980 --> 00:26:40,440
+غرام من المواد الخام إلى عشرة كيلو غرام منالمواد
+
+217
+00:26:40,440 --> 00:26:44,600
+الخام تلاتة
+
+218
+00:26:44,600 --> 00:26:48,940
+تحتفظ
+
+219
+00:26:48,940 --> 00:26:58,400
+الشركة بنسبة تحتفظ الشركة بنسبة 15% من المواد
+
+220
+00:26:58,400 --> 00:27:07,760
+الخام من المواد الخام من المواد الخام للشهر الحالي
+
+221
+00:27:09,250 --> 00:27:18,890
+من الشهر التالي الشهر الحالي من الشهر التالي رقم
+
+222
+00:27:18,890 --> 00:27:27,270
+أربعة رصيد مخزون أول المدة رصيد مخزون أول المدة من
+
+223
+00:27:27,270 --> 00:27:36,170
+المواد الخام خمس آلاف وستمية خمس آلاف وستمية كيلو
+
+224
+00:27:36,170 --> 00:27:38,250
+رام خمسة
+
+225
+00:27:39,890 --> 00:27:46,670
+تكلفة شراء الـ kilogram تكلفة شراء الـ kilogram 7
+
+226
+00:27:46,670 --> 00:27:50,850
+من 10 دنار رقم
+
+227
+00:27:50,850 --> 00:28:00,790
+6 تدفع الشركة تدفع الشركة من قيمة من قيمة
+
+228
+00:28:00,790 --> 00:28:13,330
+المشتريات 60% منها 60%في نفس شهر الشراع و 40% في
+
+229
+00:28:13,330 --> 00:28:22,330
+الشهر التالي رقم
+
+230
+00:28:22,330 --> 00:28:30,330
+سبعة وأخيرا بلغ رصيد الموردين في واحد و تلاتين
+
+231
+00:28:30,330 --> 00:28:34,450
+اتناش الفين وسبعتاش
+
+232
+00:28:36,570 --> 00:28:48,490
+2500 درار المطلوب رقم واحد اعداد موازنة
+
+233
+00:28:48,490 --> 00:28:56,570
+المواد الخام المباشرة اعداد موازنة المواد الخام
+
+234
+00:28:56,570 --> 00:28:59,730
+المباشرة
+
+235
+00:28:59,730 --> 00:29:09,020
+للربع الأولرقم اتنين موازنة التدفقات النقدية
+
+236
+00:29:09,020 --> 00:29:16,900
+المتوقعة موازنة التدفقات النقدية المتوقعة إلى الآن
+
+237
+00:29:16,900 --> 00:29:22,660
+نهيأ نفسنا ليه الحل وكما قلنا سابقا في عند اعداد
+
+238
+00:29:22,660 --> 00:29:29,140
+موازنة عند اعداد موازنة عند اعداد موازنة المواد
+
+239
+00:29:29,140 --> 00:29:39,660
+الخام المباشرة نبدأ اول شيءبإيش؟ عدد الوحدات
+
+240
+00:29:39,660 --> 00:29:49,100
+المتوقع إنتاجها وكما قلنا في السؤال في عنا الفيروس
+
+241
+00:29:49,100 --> 00:29:55,160
+سبعمية في يناير حسب التوالي الفين واربعمية خمس
+
+242
+00:29:55,160 --> 00:30:01,260
+آلاف وتمانمية وثلاث آلاف وتمانمية وإيه؟ وخمسين
+
+243
+00:30:01,260 --> 00:30:12,710
+تمام؟طيب الان بدنا نضغط في ايش؟ في سعر ال kilogram
+
+244
+00:30:12,710 --> 00:30:16,690
+بدنا نحول كيميات لان هنا في النهاية كما قلنا الهدف
+
+245
+00:30:16,690 --> 00:30:20,490
+منها انه معرفة الكيمية الواجب شرائها و الثمن
+
+246
+00:30:20,490 --> 00:30:26,150
+المرتبط و الثمن اللازم لتأمين عملية الشراء اذا
+
+247
+00:30:26,150 --> 00:30:33,590
+نضغط ايش؟ سعر الشراء وسعر الشراء هنا كام؟ هنا عشرة
+
+248
+00:30:34,110 --> 00:30:42,310
+هي عشرة هي عشرة هي عشرة إذا الآن الكمية اللازمة
+
+249
+00:30:42,310 --> 00:30:49,830
+هنا كيلو غرام إذا هنا هي سبعة و عشرين ألف وهنا
+
+250
+00:30:49,830 --> 00:30:58,410
+وهنا هي أربعة و عشرين ألف هنا تمانية و خمسين ألف
+
+251
+00:30:58,410 --> 00:31:02,310
+وهنا تمانية و تلاتين ألف و خمسمية
+
+252
+00:31:07,810 --> 00:31:12,030
+الان بعد ما وصلنا الى الكمية اللازمة للإنتاج بدنا
+
+253
+00:31:12,030 --> 00:31:18,970
+نضيف .. بدنا نضيف ايش يا عمار؟ بدنا نضيف زائد ..
+
+254
+00:31:18,970 --> 00:31:29,950
+زائد مخزون اخر المدة مواد مباشرة طيب مخزون اخر
+
+255
+00:31:29,950 --> 00:31:34,390
+المدة مواد مباشرة حكى لنا في معلومات السؤال تمثل
+
+256
+00:31:34,390 --> 00:31:41,110
+الاحتفاظ بنسبة ايش؟بنسبة خمستاشف في المية، بنسبة
+
+257
+00:31:41,110 --> 00:31:48,170
+خمستاشف في المية، إذا هاي خمستاشف في المية، هاي
+
+258
+00:31:48,170 --> 00:31:54,410
+خمستاشف في المية، وهي إيش خمستاشف في المية، إذا
+
+259
+00:31:54,410 --> 00:32:00,470
+خمستاشف في المية في أربعة و عشرين ألف ثلاث آلاف،
+
+260
+00:32:00,470 --> 00:32:10,890
+ثلاث آلاف و ستميةتمام؟ طيب 15% من الـ 58 8700
+
+261
+00:32:10,890 --> 00:32:23,570
+طيب 15% من 38500 هتطلع 577570
+
+262
+00:32:23,570 --> 00:32:29,910
+إذا نقوم بجمع الكيمية لازم نتاج زائد المخزون أخر
+
+263
+00:32:29,910 --> 00:32:37,120
+مدة الواجب الاحتفاظ بهاإذا هنا مجموع
+
+264
+00:32:37,120 --> 00:32:46,040
+الكمية المطلوبة طبعا كله كل غرام تمام؟ حيكون عندنا
+
+265
+00:32:46,040 --> 00:32:54,000
+تلاتين ألف تلاتين ألف وستمية وفي شهر فبراير حيكون
+
+266
+00:32:54,000 --> 00:33:03,090
+عندي اتنين وتلاتين ألف وسبعميةوأخيراً تلاتة أو
+
+267
+00:33:03,090 --> 00:33:08,450
+ستين ألف وسبعمية وخمسة وسبعين إذا بهذا نكون وصلنا
+
+268
+00:33:08,450 --> 00:33:14,650
+إلى الكمية المطلوبة وصلنا إلى الكمية المطلوبة طيب
+
+269
+00:33:14,650 --> 00:33:19,910
+لكن أنا الآن بتطرح منها إيش؟ أول المدة إذا هنا
+
+270
+00:33:19,910 --> 00:33:32,180
+نطرح مخزون أول المدة موادخام مواد خام أو مواد
+
+271
+00:33:32,180 --> 00:33:37,140
+مباشرة طيب مخزون أول المدة حكالك في الشعر الكام
+
+272
+00:33:37,140 --> 00:33:44,900
+لشعر الأول خمس آلاف وستمية خمس آلاف وستمية إذا هاي
+
+273
+00:33:44,900 --> 00:33:52,100
+خمس آلاف وستمية هي بين قوسين تمام؟ طيب الآن في
+
+274
+00:33:52,100 --> 00:34:00,330
+الشهر فبرايرالان مخزون نهاية المدة يعتبر ايش؟ لاحظ
+
+275
+00:34:00,330 --> 00:34:03,430
+الأسهم وضروري احط الأسهم في حل السؤال عشان يكون
+
+276
+00:34:03,430 --> 00:34:11,870
+واضح لك الان هنا هي ثلاث آلاف وستمية وهنا ثمان
+
+277
+00:34:11,870 --> 00:34:20,650
+آلاف وسبعمية اذا بهذا نصل الى الكمية اللازم شراها
+
+278
+00:34:20,650 --> 00:34:23,070
+نصل الى
+
+279
+00:34:25,950 --> 00:34:33,650
+الكمية المطلوب شرائها في
+
+280
+00:34:33,650 --> 00:34:44,130
+كل فترة طيب هنطرح خمس تلاف و ستمية من أيه؟ كام؟
+
+281
+00:34:44,130 --> 00:34:49,810
+خمس و عشرين ألف هنا؟ تسعة و عشرين ألف و مية كام؟
+
+282
+00:34:49,810 --> 00:35:00,660
+تسعة و عشرين ألفو 100 و أخيراً خمسة و خمسين ألف و
+
+283
+00:35:00,660 --> 00:35:07,580
+خمسة و سبعين إذا هذه الكمية المطلوب شراها ككميات
+
+284
+00:35:07,580 --> 00:35:13,480
+هذه الكمية المطلوب شراها بالكلورام الآن زي ما قلنا
+
+285
+00:35:13,480 --> 00:35:16,600
+إعداد موازن مواد الخام نصل فيها الكمية المطلوبة و
+
+286
+00:35:16,600 --> 00:35:25,040
+الكمية اللازمة للإنتاج و من ثم قيمة أو ثمنثمن قيمة
+
+287
+00:35:25,040 --> 00:35:34,480
+المشتريات إذا هنا هنضغط في إيش؟ في سعر الشراك سعر
+
+288
+00:35:34,480 --> 00:35:41,000
+الشراك سعر الشراك كما ورد في السال سبعة من عشرة
+
+289
+00:35:41,000 --> 00:35:49,660
+سبعة من عشرة وهنا سبعة من عشرة إذا
+
+290
+00:35:49,660 --> 00:35:51,700
+هنا إجمالي
+
+291
+00:35:56,040 --> 00:36:04,860
+المشتريات بالدينار اجمالي المشتريات بالدينار الان
+
+292
+00:36:04,860 --> 00:36:14,260
+سبعة في خمسة و عشرين سبعتاشر الف سبعتاشر الف و عشر
+
+293
+00:36:14,260 --> 00:36:18,440
+خمسمية سبعة من عشرة في تسعة و عشرين الف و مية
+
+294
+00:36:18,440 --> 00:36:28,480
+هتطلع انعشرين ألف و تلاتمية و سبعين طيب أخيراً
+
+295
+00:36:28,480 --> 00:36:35,940
+هيطلع هنا اللي هو أيه تمانية و تلاتين ألف خمسمية و
+
+296
+00:36:35,940 --> 00:36:41,850
+تلاتة و خمسين لأن بعضه فاصلة و نصف بنجربهانصف من
+
+297
+00:36:41,850 --> 00:36:48,370
+جربه أقل من نصف ليحدث لأغراض التفسير إذا هذه أجمال
+
+298
+00:36:48,370 --> 00:36:52,090
+أجمال المشتريات بالدنار فهذه جدول موازية المواد
+
+299
+00:36:52,090 --> 00:36:59,050
+الخام المباشرة ما اللي لديه أي سؤال ما اللي لديه
+
+300
+00:36:59,050 --> 00:37:07,000
+أي سؤال قبل أن نذهب إلىالمطلوب الثاني وهو إيه؟ وهو
+
+301
+00:37:07,000 --> 00:37:12,600
+إعداد جدول التدفقات النقدية المتوقعة التدفقات
+
+302
+00:37:12,600 --> 00:37:16,980
+النقدية المرتبطة بالمشتريات يعني أنا مش هقدر أدفع
+
+303
+00:37:16,980 --> 00:37:20,780
+مشتريات كلها cash اتفق مع التاجر دفعتين، تلاتة،
+
+304
+00:37:20,780 --> 00:37:25,340
+أربعة، نفس الفكرة ما يصير للدفعتين يصير في إيش؟
+
+305
+00:37:25,340 --> 00:37:36,000
+فيه تلت دفعة إذا الآن موازنة التدفقاتالنقدية طيب
+
+306
+00:37:36,000 --> 00:37:40,400
+مواقع تفوقات النقدية المتوقعة للربع الأول وراحد
+
+307
+00:37:40,400 --> 00:37:44,380
+يناير فبراير مارس بكاف ربع الأول مالزماش بقى اي
+
+308
+00:37:44,380 --> 00:37:54,380
+حاجة تانية اول شي يا شبابرصيد 112018 اللي هو ذُكرة
+
+309
+00:37:54,380 --> 00:38:01,660
+في السؤال ايش ذُكرة في السؤال 31122017 اللي هو
+
+310
+00:38:01,660 --> 00:38:14,920
+كام؟ كام عمر؟ 2500 هاي 2500 تمام؟ هاي 2500 طيب
+
+311
+00:38:16,350 --> 00:38:22,450
+الان ذكر لنا ايضا ان 60% من قيمة المشتريات تدفع في
+
+312
+00:38:22,450 --> 00:38:25,610
+شهر الشراء
+
+313
+00:38:31,670 --> 00:38:39,650
+هي يناير هاي يناير ستين في المية درهم قداش عند
+
+314
+00:38:39,650 --> 00:38:47,510
+مشتريات المتوقعة سبعتاشر الف و خمسمية دولار يعني
+
+315
+00:38:47,510 --> 00:38:51,430
+عشر تالف و ايش؟ خمسمية
+
+316
+00:38:54,130 --> 00:38:59,510
+وهنا 40% ولاحظ كما قلنا ان المشتريات يظهر ان
+
+317
+00:38:59,510 --> 00:39:03,710
+المبلغ بالكام اللي لابد ان اتوقع ندفعه بينما
+
+318
+00:39:03,710 --> 00:39:08,910
+المبيعات بنخلي نسبة قابلة لعدم التحصيل تمام؟ الـ
+
+319
+00:39:08,910 --> 00:39:18,570
+40% هتكون كام؟ سبع أعلى طيب الآن
+
+320
+00:39:18,570 --> 00:39:24,380
+نأتي ليش؟فبراير فبراير سبتين في المية ضارب ايه؟
+
+321
+00:39:24,380 --> 00:39:36,340
+عشرين الف تلاتمية و ايه؟ كام؟ عشر
+
+322
+00:39:36,340 --> 00:39:41,020
+الف و متين و اتنين و عشرين طيب بينما الاربعين في
+
+323
+00:39:41,020 --> 00:39:41,360
+المية
+
+324
+00:39:45,890 --> 00:39:51,790
+الاربعين في المية هتطلع كام ثمان
+
+325
+00:39:51,790 --> 00:40:00,850
+ألاف ومية تمانية واربعين تمام طيب الآن نعتي اليش
+
+326
+00:40:00,850 --> 00:40:11,830
+مارس مارس ستين في المية ضرب ايش تمانية وتلاتين الف
+
+327
+00:40:11,830 --> 00:40:19,930
+خمسمية وخمسة و تلاتينهتطلع عنا كام تلاتة و عشرين
+
+328
+00:40:19,930 --> 00:40:23,950
+الف و مية و اتنين و تلاتين جداش تلاتة و عشرين الف
+
+329
+00:40:23,950 --> 00:40:26,650
+و مية و اتنين و تلاتين مية و اتنين و تلاتين بتجرب
+
+330
+00:40:26,650 --> 00:40:33,070
+الان اللي عند هنا بكفي اللي عند هنا بكفي لان انا
+
+331
+00:40:33,070 --> 00:40:38,570
+بدي اجمال التدفقات النقدية المتوقع اذا هنا مجموع
+
+332
+00:40:38,570 --> 00:40:43,130
+التدفقات النقدية
+
+333
+00:40:46,040 --> 00:40:55,480
+المتوقع المتوقع اذا هنا هنا كام هنا
+
+334
+00:40:55,480 --> 00:40:58,920
+تسع
+
+335
+00:40:58,920 --> 00:41:06,680
+تاشر الف و ايش اتنين و اتنين و عشرين طيب اخيراً
+
+336
+00:41:06,680 --> 00:41:10,740
+واحد و تلاتين الف واحد و تلاتين الف و اتنين و
+
+337
+00:41:10,740 --> 00:41:12,420
+تمانين و اتنين و تمانين و اتنين و تمانين
+
+338
+00:41:20,960 --> 00:41:29,260
+واحد و تلاتين ألف و متين و تماني ما
+
+339
+00:41:29,260 --> 00:41:35,140
+اللي لديه أي سؤال؟ ما اللي لديه أي سؤال في أي نقطة
+
+340
+00:41:35,140 --> 00:41:39,820
+كان موجودة؟ مين مش فاهم؟ ده الأمور الحمد لله كنا
+
+341
+00:41:39,820 --> 00:41:44,280
+تماماطبعا في المحاضرة القادمة هنبدأ بموازنة ..
+
+342
+00:41:44,280 --> 00:41:48,980
+قلنا أنه تكلفة أي شيء مواد و أجور و تأثير ضخم طبعا
+
+343
+00:41:48,980 --> 00:41:53,460
+المرة الجاية هنبدأ في اللي هي الأجور و نكملها حسب
+
+344
+00:41:53,460 --> 00:41:58,200
+الوقت المحاضرة بهذا نكون وصلنا إلى نهاية محاضرة
+
+345
+00:41:58,200 --> 00:42:03,260
+اليوم و إلى اللقاء في محاضرة قادمة بمشيات الله
+